id	sid	tid	token	lemma	pos
cord-017954-vobslprh	1	1	key	key	NN
cord-017954-vobslprh	1	2	:	:	:
cord-017954-vobslprh	2	1	cord-017954-vobslprh	cord-017954-vobslprh	NNP
cord-017954-vobslprh	3	1	authors	author	NNS
cord-017954-vobslprh	3	2	:	:	:
cord-017954-vobslprh	4	1	Croxford	Croxford	NNP
cord-017954-vobslprh	4	2	,	,	,
cord-017954-vobslprh	4	3	J.	J.	NNP
cord-017954-vobslprh	4	4	Ludovic	Ludovic	NNP
cord-017954-vobslprh	4	5	;	;	:
cord-017954-vobslprh	4	6	Miyake	Miyake	NNP
cord-017954-vobslprh	4	7	,	,	,
cord-017954-vobslprh	4	8	Sachiko	Sachiko	NNP
cord-017954-vobslprh	4	9	title	title	NN
cord-017954-vobslprh	4	10	:	:	:
cord-017954-vobslprh	4	11	Animal	Animal	NNP
cord-017954-vobslprh	4	12	Models	model	NNS
cord-017954-vobslprh	4	13	for	for	IN
cord-017954-vobslprh	4	14	the	the	DT
cord-017954-vobslprh	4	15	Study	Study	NNP
cord-017954-vobslprh	4	16	of	of	IN
cord-017954-vobslprh	4	17	Neuroimmunological	Neuroimmunological	NNP
cord-017954-vobslprh	4	18	Disease	Disease	NNP
cord-017954-vobslprh	4	19	date	date	NN
cord-017954-vobslprh	4	20	:	:	:
cord-017954-vobslprh	4	21	2016	2016	CD
cord-017954-vobslprh	4	22	-	-	HYPH
cord-017954-vobslprh	4	23	03	03	CD
cord-017954-vobslprh	4	24	-	-	SYM
cord-017954-vobslprh	4	25	26	26	CD
cord-017954-vobslprh	4	26	journal	journal	NN
cord-017954-vobslprh	4	27	:	:	:
cord-017954-vobslprh	4	28	Neuroimmunological	Neuroimmunological	NNP
cord-017954-vobslprh	4	29	Diseases	Diseases	NNPS
cord-017954-vobslprh	4	30	DOI	DOI	NNP
cord-017954-vobslprh	4	31	:	:	:
cord-017954-vobslprh	5	1	10.1007/978	10.1007/978	LS
cord-017954-vobslprh	5	2	-	-	SYM
cord-017954-vobslprh	5	3	4	4	CD
cord-017954-vobslprh	5	4	-	-	HYPH
cord-017954-vobslprh	5	5	431	431	CD
cord-017954-vobslprh	5	6	-	-	HYPH
cord-017954-vobslprh	5	7	55594	55594	CD
cord-017954-vobslprh	5	8	-	-	SYM
cord-017954-vobslprh	5	9	0_3	0_3	CD
cord-017954-vobslprh	6	1	sha	sha	NNP
cord-017954-vobslprh	6	2	:	:	:
cord-017954-vobslprh	7	1	f112c54cb08caca42865c197c3389393c3a63cb7	f112c54cb08caca42865c197c3389393c3a63cb7	RB
cord-017954-vobslprh	7	2	doc_id	doc_id	CD
cord-017954-vobslprh	8	1	:	:	:
cord-017954-vobslprh	8	2	17954	17954	CD
cord-017954-vobslprh	8	3	cord_uid	cord_uid	NNS
cord-017954-vobslprh	8	4	:	:	:
cord-017954-vobslprh	9	1	vobslprh	vobslprh	NNP
cord-017954-vobslprh	10	1	The	the	DT
cord-017954-vobslprh	10	2	development	development	NN
cord-017954-vobslprh	10	3	and	and	CC
cord-017954-vobslprh	10	4	use	use	NN
cord-017954-vobslprh	10	5	of	of	IN
cord-017954-vobslprh	10	6	numerous	numerous	JJ
cord-017954-vobslprh	10	7	animal	animal	NN
cord-017954-vobslprh	10	8	models	model	NNS
cord-017954-vobslprh	10	9	of	of	IN
cord-017954-vobslprh	10	10	human	human	JJ
cord-017954-vobslprh	10	11	autoimmune	autoimmune	JJ
cord-017954-vobslprh	10	12	diseases	disease	NNS
cord-017954-vobslprh	10	13	have	have	VBP
cord-017954-vobslprh	10	14	provided	provide	VBN
cord-017954-vobslprh	10	15	important	important	JJ
cord-017954-vobslprh	10	16	advances	advance	NNS
cord-017954-vobslprh	10	17	in	in	IN
cord-017954-vobslprh	10	18	our	-PRON-	PRP$
cord-017954-vobslprh	10	19	understanding	understanding	NN
cord-017954-vobslprh	10	20	of	of	IN
cord-017954-vobslprh	10	21	pathogenic	pathogenic	JJ
cord-017954-vobslprh	10	22	mechanisms	mechanism	NNS
cord-017954-vobslprh	10	23	of	of	IN
cord-017954-vobslprh	10	24	disease	disease	NN
cord-017954-vobslprh	10	25	and	and	CC
cord-017954-vobslprh	10	26	provided	provide	VBD
cord-017954-vobslprh	10	27	robust	robust	JJ
cord-017954-vobslprh	10	28	and	and	CC
cord-017954-vobslprh	10	29	reliable	reliable	JJ
cord-017954-vobslprh	10	30	models	model	NNS
cord-017954-vobslprh	10	31	to	to	TO
cord-017954-vobslprh	10	32	test	test	VB
cord-017954-vobslprh	10	33	novel	novel	JJ
cord-017954-vobslprh	10	34	therapeutic	therapeutic	JJ
cord-017954-vobslprh	10	35	strategies	strategy	NNS
cord-017954-vobslprh	10	36	.	.	.
cord-017954-vobslprh	11	1	However	however	RB
cord-017954-vobslprh	11	2	,	,	,
cord-017954-vobslprh	11	3	few	few	JJ
cord-017954-vobslprh	11	4	preclinical	preclinical	JJ
cord-017954-vobslprh	11	5	studies	study	NNS
cord-017954-vobslprh	11	6	of	of	IN
cord-017954-vobslprh	11	7	therapeutic	therapeutic	JJ
cord-017954-vobslprh	11	8	treatments	treatment	NNS
cord-017954-vobslprh	11	9	have	have	VBP
cord-017954-vobslprh	11	10	demonstrated	demonstrate	VBN
cord-017954-vobslprh	11	11	efficacy	efficacy	NN
cord-017954-vobslprh	11	12	in	in	IN
cord-017954-vobslprh	11	13	the	the	DT
cord-017954-vobslprh	11	14	clinic	clinic	NN
cord-017954-vobslprh	11	15	,	,	,
cord-017954-vobslprh	11	16	possibly	possibly	RB
cord-017954-vobslprh	11	17	because	because	IN
cord-017954-vobslprh	11	18	of	of	IN
cord-017954-vobslprh	11	19	the	the	DT
cord-017954-vobslprh	11	20	biological	biological	JJ
cord-017954-vobslprh	11	21	differences	difference	NNS
cord-017954-vobslprh	11	22	between	between	IN
cord-017954-vobslprh	11	23	humans	human	NNS
cord-017954-vobslprh	11	24	and	and	CC
cord-017954-vobslprh	11	25	other	other	JJ
cord-017954-vobslprh	11	26	animals	animal	NNS
cord-017954-vobslprh	11	27	.	.	.
cord-017954-vobslprh	12	1	Although	although	IN
cord-017954-vobslprh	12	2	animal	animal	NN
cord-017954-vobslprh	12	3	models	model	NNS
cord-017954-vobslprh	12	4	of	of	IN
cord-017954-vobslprh	12	5	human	human	JJ
cord-017954-vobslprh	12	6	disease	disease	NN
cord-017954-vobslprh	12	7	are	be	VBP
cord-017954-vobslprh	12	8	imperfect	imperfect	JJ
cord-017954-vobslprh	12	9	,	,	,
cord-017954-vobslprh	12	10	it	-PRON-	PRP
cord-017954-vobslprh	12	11	is	be	VBZ
cord-017954-vobslprh	12	12	important	important	JJ
cord-017954-vobslprh	12	13	to	to	TO
cord-017954-vobslprh	12	14	understand	understand	VB
cord-017954-vobslprh	12	15	the	the	DT
cord-017954-vobslprh	12	16	differences	difference	NNS
cord-017954-vobslprh	12	17	between	between	IN
cord-017954-vobslprh	12	18	the	the	DT
cord-017954-vobslprh	12	19	human	human	JJ
cord-017954-vobslprh	12	20	disease	disease	NN
cord-017954-vobslprh	12	21	and	and	CC
cord-017954-vobslprh	12	22	its	-PRON-	PRP$
cord-017954-vobslprh	12	23	animal	animal	NN
cord-017954-vobslprh	12	24	models	model	NNS
cord-017954-vobslprh	12	25	and	and	CC
cord-017954-vobslprh	12	26	to	to	TO
cord-017954-vobslprh	12	27	design	design	VB
cord-017954-vobslprh	12	28	experimental	experimental	JJ
cord-017954-vobslprh	12	29	studies	study	NNS
cord-017954-vobslprh	12	30	using	use	VBG
cord-017954-vobslprh	12	31	animal	animal	NN
cord-017954-vobslprh	12	32	models	model	NNS
cord-017954-vobslprh	12	33	appropriately	appropriately	RB
cord-017954-vobslprh	12	34	for	for	IN
cord-017954-vobslprh	12	35	the	the	DT
cord-017954-vobslprh	12	36	questions	question	NNS
cord-017954-vobslprh	12	37	being	be	VBG
cord-017954-vobslprh	12	38	asked	ask	VBN
cord-017954-vobslprh	12	39	.	.	.
cord-017954-vobslprh	13	1	This	this	DT
cord-017954-vobslprh	13	2	review	review	NN
cord-017954-vobslprh	13	3	provides	provide	VBZ
cord-017954-vobslprh	13	4	an	an	DT
cord-017954-vobslprh	13	5	overview	overview	NN
cord-017954-vobslprh	13	6	of	of	IN
cord-017954-vobslprh	13	7	the	the	DT
cord-017954-vobslprh	13	8	currently	currently	RB
cord-017954-vobslprh	13	9	used	use	VBN
cord-017954-vobslprh	13	10	animal	animal	NN
cord-017954-vobslprh	13	11	models	model	NNS
cord-017954-vobslprh	13	12	of	of	IN
cord-017954-vobslprh	13	13	three	three	CD
cord-017954-vobslprh	13	14	human	human	JJ
cord-017954-vobslprh	13	15	neuroimmunological	neuroimmunological	JJ
cord-017954-vobslprh	13	16	diseases	disease	NNS
cord-017954-vobslprh	13	17	,	,	,
cord-017954-vobslprh	13	18	multiple	multiple	JJ
cord-017954-vobslprh	13	19	sclerosis	sclerosis	NN
cord-017954-vobslprh	13	20	,	,	,
cord-017954-vobslprh	13	21	Guillain	Guillain	NNP
cord-017954-vobslprh	13	22	-	-	HYPH
cord-017954-vobslprh	13	23	Barré	Barré	NNP
cord-017954-vobslprh	13	24	syndrome	syndrome	NN
cord-017954-vobslprh	13	25	,	,	,
cord-017954-vobslprh	13	26	and	and	CC
cord-017954-vobslprh	13	27	myasthenia	myasthenia	NN
cord-017954-vobslprh	13	28	gravis	gravis	NNP
cord-017954-vobslprh	13	29	,	,	,
cord-017954-vobslprh	13	30	as	as	RB
cord-017954-vobslprh	13	31	well	well	RB
cord-017954-vobslprh	13	32	as	as	IN
cord-017954-vobslprh	13	33	the	the	DT
cord-017954-vobslprh	13	34	advantages	advantage	NNS
cord-017954-vobslprh	13	35	and	and	CC
cord-017954-vobslprh	13	36	disadvantages	disadvantage	NNS
cord-017954-vobslprh	13	37	of	of	IN
cord-017954-vobslprh	13	38	each	each	DT
cord-017954-vobslprh	13	39	model	model	NN
cord-017954-vobslprh	13	40	and	and	CC
cord-017954-vobslprh	13	41	how	how	WRB
cord-017954-vobslprh	13	42	they	-PRON-	PRP
cord-017954-vobslprh	13	43	correlate	correlate	VBP
cord-017954-vobslprh	13	44	or	or	CC
cord-017954-vobslprh	13	45	differ	differ	VBP
cord-017954-vobslprh	13	46	from	from	IN
cord-017954-vobslprh	13	47	their	-PRON-	PRP$
cord-017954-vobslprh	13	48	human	human	JJ
cord-017954-vobslprh	13	49	counterpart	counterpart	NN
cord-017954-vobslprh	13	50	.	.	.
cord-017954-vobslprh	14	1	Following	follow	VBG
cord-017954-vobslprh	14	2	decades	decade	NNS
cord-017954-vobslprh	14	3	of	of	IN
cord-017954-vobslprh	14	4	research	research	NN
cord-017954-vobslprh	14	5	,	,	,
cord-017954-vobslprh	14	6	scientists	scientist	NNS
cord-017954-vobslprh	14	7	have	have	VBP
cord-017954-vobslprh	14	8	developed	develop	VBN
cord-017954-vobslprh	14	9	a	a	DT
cord-017954-vobslprh	14	10	large	large	JJ
cord-017954-vobslprh	14	11	number	number	NN
cord-017954-vobslprh	14	12	of	of	IN
cord-017954-vobslprh	14	13	drugs	drug	NNS
cord-017954-vobslprh	14	14	and	and	CC
cord-017954-vobslprh	14	15	therapeutic	therapeutic	JJ
cord-017954-vobslprh	14	16	agents	agent	NNS
cord-017954-vobslprh	14	17	that	that	WDT
cord-017954-vobslprh	14	18	can	can	MD
cord-017954-vobslprh	14	19	be	be	VB
cord-017954-vobslprh	14	20	used	use	VBN
cord-017954-vobslprh	14	21	to	to	TO
cord-017954-vobslprh	14	22	reduce	reduce	VB
cord-017954-vobslprh	14	23	the	the	DT
cord-017954-vobslprh	14	24	symptoms	symptom	NNS
cord-017954-vobslprh	14	25	and	and	CC
cord-017954-vobslprh	14	26	severity	severity	NN
cord-017954-vobslprh	14	27	of	of	IN
cord-017954-vobslprh	14	28	a	a	DT
cord-017954-vobslprh	14	29	number	number	NN
cord-017954-vobslprh	14	30	of	of	IN
cord-017954-vobslprh	14	31	neuroimmunological	neuroimmunological	JJ
cord-017954-vobslprh	14	32	diseases	disease	NNS
cord-017954-vobslprh	14	33	such	such	JJ
cord-017954-vobslprh	14	34	as	as	IN
cord-017954-vobslprh	14	35	multiple	multiple	JJ
cord-017954-vobslprh	14	36	sclerosis	sclerosis	NN
cord-017954-vobslprh	14	37	(	(	-LRB-
cord-017954-vobslprh	14	38	MS	MS	NNP
cord-017954-vobslprh	14	39	)	)	-RRB-
cord-017954-vobslprh	14	40	,	,	,
cord-017954-vobslprh	14	41	neuritis	neuritis	NN
cord-017954-vobslprh	14	42	,	,	,
cord-017954-vobslprh	14	43	and	and	CC
cord-017954-vobslprh	14	44	myasthenia	myasthenia	NN
cord-017954-vobslprh	14	45	gravis	gravis	NN
cord-017954-vobslprh	14	46	.	.	.
cord-017954-vobslprh	15	1	However	however	RB
cord-017954-vobslprh	15	2	,	,	,
cord-017954-vobslprh	15	3	none	none	NN
cord-017954-vobslprh	15	4	of	of	IN
cord-017954-vobslprh	15	5	these	these	DT
cord-017954-vobslprh	15	6	treatment	treatment	NN
cord-017954-vobslprh	15	7	methodologies	methodology	NNS
cord-017954-vobslprh	15	8	is	be	VBZ
cord-017954-vobslprh	15	9	curative	curative	JJ
cord-017954-vobslprh	15	10	,	,	,
cord-017954-vobslprh	15	11	and	and	CC
cord-017954-vobslprh	15	12	many	many	JJ
cord-017954-vobslprh	15	13	have	have	VBP
cord-017954-vobslprh	15	14	a	a	DT
cord-017954-vobslprh	15	15	limited	limited	JJ
cord-017954-vobslprh	15	16	life	life	NN
cord-017954-vobslprh	15	17	span	span	NN
cord-017954-vobslprh	15	18	,	,	,
cord-017954-vobslprh	15	19	such	such	JJ
cord-017954-vobslprh	15	20	as	as	IN
cord-017954-vobslprh	15	21	interferon	interferon	NN
cord-017954-vobslprh	16	1	(	(	-LRB-
cord-017954-vobslprh	16	2	IFN)-β	IFN)-β	NNP
cord-017954-vobslprh	16	3	that	that	WDT
cord-017954-vobslprh	16	4	induces	induce	VBZ
cord-017954-vobslprh	16	5	neutralizing	neutralize	VBG
cord-017954-vobslprh	16	6	antibodies	antibody	NNS
cord-017954-vobslprh	16	7	in	in	IN
cord-017954-vobslprh	16	8	some	some	DT
cord-017954-vobslprh	16	9	MS	MS	NNP
cord-017954-vobslprh	16	10	patients	patient	NNS
cord-017954-vobslprh	16	11	[	[	-LRB-
cord-017954-vobslprh	16	12	1	1	CD
cord-017954-vobslprh	16	13	]	]	-RRB-
cord-017954-vobslprh	16	14	,	,	,
cord-017954-vobslprh	16	15	or	or	CC
cord-017954-vobslprh	16	16	cause	cause	VB
cord-017954-vobslprh	16	17	serious	serious	JJ
cord-017954-vobslprh	16	18	side	side	NN
cord-017954-vobslprh	16	19	effects	effect	NNS
cord-017954-vobslprh	16	20	(	(	-LRB-
cord-017954-vobslprh	16	21	progressive	progressive	JJ
cord-017954-vobslprh	16	22	multifocal	multifocal	JJ
cord-017954-vobslprh	16	23	leucoencephalopathy	leucoencephalopathy	NNP
cord-017954-vobslprh	16	24	)	)	-RRB-
cord-017954-vobslprh	16	25	such	such	JJ
cord-017954-vobslprh	16	26	as	as	IN
cord-017954-vobslprh	16	27	monoclonal	monoclonal	JJ
cord-017954-vobslprh	16	28	anti	anti	RB
cord-017954-vobslprh	16	29	-	-	JJ
cord-017954-vobslprh	16	30	very	very	RB
cord-017954-vobslprh	16	31	late	late	JJ
cord-017954-vobslprh	16	32	antigen	antigen	NN
cord-017954-vobslprh	16	33	(	(	-LRB-
cord-017954-vobslprh	16	34	VLA)-4	vla)-4	JJ
cord-017954-vobslprh	16	35	antibodies	antibody	NNS
cord-017954-vobslprh	16	36	(	(	-LRB-
cord-017954-vobslprh	16	37	natalizumab	natalizumab	NNS
cord-017954-vobslprh	16	38	,	,	,
cord-017954-vobslprh	16	39	Tysabri	Tysabri	NNP
cord-017954-vobslprh	16	40	®	®	POS
cord-017954-vobslprh	16	41	)	)	-RRB-
cord-017954-vobslprh	16	42	[	[	-LRB-
cord-017954-vobslprh	16	43	2	2	CD
cord-017954-vobslprh	16	44	]	]	-RRB-
cord-017954-vobslprh	16	45	and	and	CC
cord-017954-vobslprh	16	46	thus	thus	RB
cord-017954-vobslprh	16	47	cause	cause	VB
cord-017954-vobslprh	16	48	patients	patient	NNS
cord-017954-vobslprh	16	49	to	to	TO
cord-017954-vobslprh	16	50	drop	drop	VB
cord-017954-vobslprh	16	51	out	out	IN
cord-017954-vobslprh	16	52	of	of	IN
cord-017954-vobslprh	16	53	clinical	clinical	JJ
cord-017954-vobslprh	16	54	trials	trial	NNS
cord-017954-vobslprh	16	55	or	or	CC
cord-017954-vobslprh	16	56	stop	stop	VB
cord-017954-vobslprh	16	57	taking	take	VBG
cord-017954-vobslprh	16	58	the	the	DT
cord-017954-vobslprh	16	59	treatment	treatment	NN
cord-017954-vobslprh	16	60	.	.	.
cord-017954-vobslprh	17	1	In	in	IN
cord-017954-vobslprh	17	2	addition	addition	NN
cord-017954-vobslprh	17	3	,	,	,
cord-017954-vobslprh	17	4	although	although	IN
cord-017954-vobslprh	17	5	many	many	JJ
cord-017954-vobslprh	17	6	studies	study	NNS
cord-017954-vobslprh	17	7	have	have	VBP
cord-017954-vobslprh	17	8	dissected	dissect	VBN
cord-017954-vobslprh	17	9	the	the	DT
cord-017954-vobslprh	17	10	intricate	intricate	JJ
cord-017954-vobslprh	17	11	pathways	pathway	NNS
cord-017954-vobslprh	17	12	involved	involve	VBN
cord-017954-vobslprh	17	13	in	in	IN
cord-017954-vobslprh	17	14	the	the	DT
cord-017954-vobslprh	17	15	aetiology	aetiology	NN
cord-017954-vobslprh	17	16	,	,	,
cord-017954-vobslprh	17	17	development	development	NN
cord-017954-vobslprh	17	18	,	,	,
cord-017954-vobslprh	17	19	and	and	CC
cord-017954-vobslprh	17	20	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	17	21	of	of	IN
cord-017954-vobslprh	17	22	diseases	disease	NNS
cord-017954-vobslprh	17	23	such	such	JJ
cord-017954-vobslprh	17	24	as	as	IN
cord-017954-vobslprh	17	25	MS	MS	NNP
cord-017954-vobslprh	17	26	,	,	,
cord-017954-vobslprh	17	27	we	-PRON-	PRP
cord-017954-vobslprh	17	28	still	still	RB
cord-017954-vobslprh	17	29	do	do	VBP
cord-017954-vobslprh	17	30	not	not	RB
cord-017954-vobslprh	17	31	have	have	VB
cord-017954-vobslprh	17	32	a	a	DT
cord-017954-vobslprh	17	33	definitive	definitive	JJ
cord-017954-vobslprh	17	34	understanding	understanding	NN
cord-017954-vobslprh	17	35	of	of	IN
cord-017954-vobslprh	17	36	how	how	WRB
cord-017954-vobslprh	17	37	these	these	DT
cord-017954-vobslprh	17	38	diseases	disease	NNS
cord-017954-vobslprh	17	39	manifest	manifest	VBP
cord-017954-vobslprh	17	40	and	and	CC
cord-017954-vobslprh	17	41	,	,	,
cord-017954-vobslprh	17	42	indeed	indeed	RB
cord-017954-vobslprh	17	43	in	in	IN
cord-017954-vobslprh	17	44	the	the	DT
cord-017954-vobslprh	17	45	case	case	NN
cord-017954-vobslprh	17	46	of	of	IN
cord-017954-vobslprh	17	47	MS	MS	NNP
cord-017954-vobslprh	17	48	,	,	,
cord-017954-vobslprh	17	49	whether	whether	IN
cord-017954-vobslprh	17	50	it	-PRON-	PRP
cord-017954-vobslprh	17	51	is	be	VBZ
cord-017954-vobslprh	17	52	a	a	DT
cord-017954-vobslprh	17	53	single	single	JJ
cord-017954-vobslprh	17	54	disease	disease	NN
cord-017954-vobslprh	17	55	or	or	CC
cord-017954-vobslprh	17	56	rather	rather	RB
cord-017954-vobslprh	17	57	a	a	DT
cord-017954-vobslprh	17	58	spectrum	spectrum	NN
cord-017954-vobslprh	17	59	of	of	IN
cord-017954-vobslprh	17	60	disorders	disorder	NNS
cord-017954-vobslprh	17	61	with	with	IN
cord-017954-vobslprh	17	62	similar	similar	JJ
cord-017954-vobslprh	17	63	characteristics	characteristic	NNS
cord-017954-vobslprh	17	64	.	.	.
cord-017954-vobslprh	18	1	Therefore	therefore	RB
cord-017954-vobslprh	18	2	,	,	,
cord-017954-vobslprh	18	3	researchers	researcher	NNS
cord-017954-vobslprh	18	4	have	have	VBP
cord-017954-vobslprh	18	5	used	use	VBN
cord-017954-vobslprh	18	6	animal	animal	NN
cord-017954-vobslprh	18	7	models	model	NNS
cord-017954-vobslprh	18	8	to	to	TO
cord-017954-vobslprh	18	9	aid	aid	VB
cord-017954-vobslprh	18	10	our	-PRON-	PRP$
cord-017954-vobslprh	18	11	understanding	understanding	NN
cord-017954-vobslprh	18	12	of	of	IN
cord-017954-vobslprh	18	13	disease	disease	NN
cord-017954-vobslprh	18	14	pathways	pathway	NNS
cord-017954-vobslprh	18	15	,	,	,
cord-017954-vobslprh	18	16	immune	immune	JJ
cord-017954-vobslprh	18	17	cell	cell	NN
cord-017954-vobslprh	18	18	functions	function	NNS
cord-017954-vobslprh	18	19	,	,	,
cord-017954-vobslprh	18	20	and	and	CC
cord-017954-vobslprh	18	21	pathology	pathology	NN
cord-017954-vobslprh	18	22	.	.	.
cord-017954-vobslprh	19	1	An	an	DT
cord-017954-vobslprh	19	2	example	example	NN
cord-017954-vobslprh	19	3	of	of	IN
cord-017954-vobslprh	19	4	the	the	DT
cord-017954-vobslprh	19	5	importance	importance	NN
cord-017954-vobslprh	19	6	of	of	IN
cord-017954-vobslprh	19	7	animal	animal	NN
cord-017954-vobslprh	19	8	models	model	NNS
cord-017954-vobslprh	19	9	was	be	VBD
cord-017954-vobslprh	19	10	the	the	DT
cord-017954-vobslprh	19	11	demonstration	demonstration	NN
cord-017954-vobslprh	19	12	that	that	WDT
cord-017954-vobslprh	19	13	CD4	CD4	NNP
cord-017954-vobslprh	19	14	T	T	NNP
cord-017954-vobslprh	19	15	cells	cell	NNS
cord-017954-vobslprh	19	16	specific	specific	JJ
cord-017954-vobslprh	19	17	for	for	IN
cord-017954-vobslprh	19	18	a	a	DT
cord-017954-vobslprh	19	19	myelin	myelin	JJ
cord-017954-vobslprh	19	20	epitope	epitope	NN
cord-017954-vobslprh	19	21	injected	inject	VBN
cord-017954-vobslprh	19	22	into	into	IN
cord-017954-vobslprh	19	23	naïve	naïve	JJ
cord-017954-vobslprh	19	24	animals	animal	NNS
cord-017954-vobslprh	19	25	were	be	VBD
cord-017954-vobslprh	19	26	sufficient	sufficient	JJ
cord-017954-vobslprh	19	27	to	to	TO
cord-017954-vobslprh	19	28	induce	induce	VB
cord-017954-vobslprh	19	29	a	a	DT
cord-017954-vobslprh	19	30	central	central	JJ
cord-017954-vobslprh	19	31	nervous	nervous	JJ
cord-017954-vobslprh	19	32	system	system	NN
cord-017954-vobslprh	19	33	(	(	-LRB-
cord-017954-vobslprh	19	34	CNS	CNS	NNP
cord-017954-vobslprh	19	35	)	)	-RRB-
cord-017954-vobslprh	19	36	demyelinating	demyelinate	VBG
cord-017954-vobslprh	19	37	disease	disease	NN
cord-017954-vobslprh	19	38	with	with	IN
cord-017954-vobslprh	19	39	CNS	CNS	NNP
cord-017954-vobslprh	19	40	lesions	lesion	NNS
cord-017954-vobslprh	19	41	similar	similar	JJ
cord-017954-vobslprh	19	42	to	to	IN
cord-017954-vobslprh	19	43	those	those	DT
cord-017954-vobslprh	19	44	observed	observe	VBN
cord-017954-vobslprh	19	45	in	in	IN
cord-017954-vobslprh	19	46	MS	MS	NNP
cord-017954-vobslprh	19	47	[	[	-LRB-
cord-017954-vobslprh	19	48	3	3	CD
cord-017954-vobslprh	19	49	,	,	,
cord-017954-vobslprh	19	50	4	4	CD
cord-017954-vobslprh	19	51	]	]	-RRB-
cord-017954-vobslprh	19	52	.	.	.
cord-017954-vobslprh	20	1	In	in	IN
cord-017954-vobslprh	20	2	addition	addition	NN
cord-017954-vobslprh	20	3	,	,	,
cord-017954-vobslprh	20	4	these	these	DT
cord-017954-vobslprh	20	5	models	model	NNS
cord-017954-vobslprh	20	6	are	be	VBP
cord-017954-vobslprh	20	7	a	a	DT
cord-017954-vobslprh	20	8	useful	useful	JJ
cord-017954-vobslprh	20	9	preclinical	preclinical	JJ
cord-017954-vobslprh	20	10	aid	aid	NN
cord-017954-vobslprh	20	11	to	to	IN
cord-017954-vobslprh	20	12	developing	develop	VBG
cord-017954-vobslprh	20	13	novel	novel	JJ
cord-017954-vobslprh	20	14	therapeutic	therapeutic	JJ
cord-017954-vobslprh	20	15	agents	agent	NNS
cord-017954-vobslprh	20	16	.	.	.
cord-017954-vobslprh	21	1	Many	many	JJ
cord-017954-vobslprh	21	2	different	different	JJ
cord-017954-vobslprh	21	3	animal	animal	NN
cord-017954-vobslprh	21	4	models	model	NNS
cord-017954-vobslprh	21	5	of	of	IN
cord-017954-vobslprh	21	6	neuroimmunological	neuroimmunological	JJ
cord-017954-vobslprh	21	7	disorders	disorder	NNS
cord-017954-vobslprh	21	8	have	have	VBP
cord-017954-vobslprh	21	9	been	be	VBN
cord-017954-vobslprh	21	10	developed	develop	VBN
cord-017954-vobslprh	21	11	over	over	IN
cord-017954-vobslprh	21	12	the	the	DT
cord-017954-vobslprh	21	13	last	last	JJ
cord-017954-vobslprh	21	14	few	few	JJ
cord-017954-vobslprh	21	15	decades	decade	NNS
cord-017954-vobslprh	21	16	with	with	IN
cord-017954-vobslprh	21	17	some	some	DT
cord-017954-vobslprh	21	18	success	success	NN
cord-017954-vobslprh	21	19	.	.	.
cord-017954-vobslprh	22	1	However	however	RB
cord-017954-vobslprh	22	2	,	,	,
cord-017954-vobslprh	22	3	it	-PRON-	PRP
cord-017954-vobslprh	22	4	is	be	VBZ
cord-017954-vobslprh	22	5	important	important	JJ
cord-017954-vobslprh	22	6	to	to	TO
cord-017954-vobslprh	22	7	understand	understand	VB
cord-017954-vobslprh	22	8	the	the	DT
cord-017954-vobslprh	22	9	advantages	advantage	NNS
cord-017954-vobslprh	22	10	and	and	CC
cord-017954-vobslprh	22	11	limitations	limitation	NNS
cord-017954-vobslprh	22	12	of	of	IN
cord-017954-vobslprh	22	13	each	each	DT
cord-017954-vobslprh	22	14	model	model	NN
cord-017954-vobslprh	22	15	to	to	TO
cord-017954-vobslprh	22	16	ensure	ensure	VB
cord-017954-vobslprh	22	17	that	that	IN
cord-017954-vobslprh	22	18	the	the	DT
cord-017954-vobslprh	22	19	correct	correct	JJ
cord-017954-vobslprh	22	20	model	model	NN
cord-017954-vobslprh	22	21	is	be	VBZ
cord-017954-vobslprh	22	22	being	be	VBG
cord-017954-vobslprh	22	23	used	use	VBN
cord-017954-vobslprh	22	24	for	for	IN
cord-017954-vobslprh	22	25	the	the	DT
cord-017954-vobslprh	22	26	purpose	purpose	NN
cord-017954-vobslprh	22	27	of	of	IN
cord-017954-vobslprh	22	28	the	the	DT
cord-017954-vobslprh	22	29	study	study	NN
cord-017954-vobslprh	22	30	.	.	.
cord-017954-vobslprh	23	1	In	in	IN
cord-017954-vobslprh	23	2	this	this	DT
cord-017954-vobslprh	23	3	review	review	NN
cord-017954-vobslprh	23	4	,	,	,
cord-017954-vobslprh	23	5	we	-PRON-	PRP
cord-017954-vobslprh	23	6	provide	provide	VBP
cord-017954-vobslprh	23	7	an	an	DT
cord-017954-vobslprh	23	8	overview	overview	NN
cord-017954-vobslprh	23	9	of	of	IN
cord-017954-vobslprh	23	10	the	the	DT
cord-017954-vobslprh	23	11	currently	currently	RB
cord-017954-vobslprh	23	12	available	available	JJ
cord-017954-vobslprh	23	13	neuroimmunological	neuroimmunological	JJ
cord-017954-vobslprh	23	14	disease	disease	NN
cord-017954-vobslprh	23	15	animal	animal	NN
cord-017954-vobslprh	23	16	models	model	NNS
cord-017954-vobslprh	23	17	,	,	,
cord-017954-vobslprh	23	18	describing	describe	VBG
cord-017954-vobslprh	23	19	their	-PRON-	PRP$
cord-017954-vobslprh	23	20	advantages	advantage	NNS
cord-017954-vobslprh	23	21	and	and	CC
cord-017954-vobslprh	23	22	disadvantages	disadvantage	NNS
cord-017954-vobslprh	23	23	as	as	RB
cord-017954-vobslprh	23	24	well	well	RB
cord-017954-vobslprh	23	25	as	as	IN
cord-017954-vobslprh	23	26	their	-PRON-	PRP$
cord-017954-vobslprh	23	27	relationship	relationship	NN
cord-017954-vobslprh	23	28	and	and	CC
cord-017954-vobslprh	23	29	correlation	correlation	NN
cord-017954-vobslprh	23	30	to	to	IN
cord-017954-vobslprh	23	31	the	the	DT
cord-017954-vobslprh	23	32	human	human	JJ
cord-017954-vobslprh	23	33	disease	disease	NN
cord-017954-vobslprh	23	34	they	-PRON-	PRP
cord-017954-vobslprh	23	35	are	be	VBP
cord-017954-vobslprh	23	36	attempting	attempt	VBG
cord-017954-vobslprh	23	37	to	to	TO
cord-017954-vobslprh	23	38	model	model	VB
cord-017954-vobslprh	23	39	.	.	.
cord-017954-vobslprh	24	1	Although	although	IN
cord-017954-vobslprh	24	2	no	no	DT
cord-017954-vobslprh	24	3	one	one	CD
cord-017954-vobslprh	24	4	animal	animal	NN
cord-017954-vobslprh	24	5	model	model	NN
cord-017954-vobslprh	24	6	is	be	VBZ
cord-017954-vobslprh	24	7	completely	completely	RB
cord-017954-vobslprh	24	8	identical	identical	JJ
cord-017954-vobslprh	24	9	with	with	IN
cord-017954-vobslprh	24	10	human	human	JJ
cord-017954-vobslprh	24	11	disease	disease	NN
cord-017954-vobslprh	24	12	,	,	,
cord-017954-vobslprh	24	13	they	-PRON-	PRP
cord-017954-vobslprh	24	14	are	be	VBP
cord-017954-vobslprh	24	15	nevertheless	nevertheless	RB
cord-017954-vobslprh	24	16	very	very	RB
cord-017954-vobslprh	24	17	useful	useful	JJ
cord-017954-vobslprh	24	18	and	and	CC
cord-017954-vobslprh	24	19	important	important	JJ
cord-017954-vobslprh	24	20	tools	tool	NNS
cord-017954-vobslprh	24	21	with	with	IN
cord-017954-vobslprh	24	22	which	which	WDT
cord-017954-vobslprh	24	23	to	to	TO
cord-017954-vobslprh	24	24	increase	increase	VB
cord-017954-vobslprh	24	25	our	-PRON-	PRP$
cord-017954-vobslprh	24	26	understanding	understanding	NN
cord-017954-vobslprh	24	27	of	of	IN
cord-017954-vobslprh	24	28	neuroimmunological	neuroimmunological	JJ
cord-017954-vobslprh	24	29	disease	disease	NN
cord-017954-vobslprh	24	30	when	when	WRB
cord-017954-vobslprh	24	31	used	use	VBN
cord-017954-vobslprh	24	32	correctly	correctly	RB
cord-017954-vobslprh	24	33	.	.	.
cord-017954-vobslprh	25	1	MS	MS	NNP
cord-017954-vobslprh	25	2	is	be	VBZ
cord-017954-vobslprh	25	3	a	a	DT
cord-017954-vobslprh	25	4	human	human	JJ
cord-017954-vobslprh	25	5	,	,	,
cord-017954-vobslprh	25	6	inflammatory	inflammatory	JJ
cord-017954-vobslprh	25	7	,	,	,
cord-017954-vobslprh	25	8	demyelinating	demyelinate	VBG
cord-017954-vobslprh	25	9	disease	disease	NN
cord-017954-vobslprh	25	10	of	of	IN
cord-017954-vobslprh	25	11	the	the	DT
cord-017954-vobslprh	25	12	CNS	CNS	NNP
cord-017954-vobslprh	25	13	,	,	,
cord-017954-vobslprh	25	14	with	with	IN
cord-017954-vobslprh	25	15	characteristic	characteristic	JJ
cord-017954-vobslprh	25	16	demyelinating	demyelinating	JJ
cord-017954-vobslprh	25	17	lesions	lesion	NNS
cord-017954-vobslprh	25	18	containing	contain	VBG
cord-017954-vobslprh	25	19	immune	immune	JJ
cord-017954-vobslprh	25	20	cell	cell	NN
cord-017954-vobslprh	25	21	infiltrate	infiltrate	NN
cord-017954-vobslprh	25	22	and	and	CC
cord-017954-vobslprh	25	23	activated	activate	VBN
cord-017954-vobslprh	25	24	CNS	CNS	NNP
cord-017954-vobslprh	25	25	-	-	HYPH
cord-017954-vobslprh	25	26	resident	resident	NN
cord-017954-vobslprh	25	27	cells	cell	NNS
cord-017954-vobslprh	25	28	located	locate	VBN
cord-017954-vobslprh	25	29	in	in	IN
cord-017954-vobslprh	25	30	the	the	DT
cord-017954-vobslprh	25	31	white	white	JJ
cord-017954-vobslprh	25	32	matter	matter	NN
cord-017954-vobslprh	25	33	of	of	IN
cord-017954-vobslprh	25	34	the	the	DT
cord-017954-vobslprh	25	35	brain	brain	NN
cord-017954-vobslprh	25	36	and	and	CC
cord-017954-vobslprh	25	37	spinal	spinal	JJ
cord-017954-vobslprh	25	38	cord	cord	NN
cord-017954-vobslprh	25	39	;	;	:
cord-017954-vobslprh	25	40	therefore	therefore	RB
cord-017954-vobslprh	25	41	,	,	,
cord-017954-vobslprh	25	42	studies	study	NNS
cord-017954-vobslprh	25	43	to	to	TO
cord-017954-vobslprh	25	44	investigate	investigate	VB
cord-017954-vobslprh	25	45	its	-PRON-	PRP$
cord-017954-vobslprh	25	46	pathology	pathology	NN
cord-017954-vobslprh	25	47	are	be	VBP
cord-017954-vobslprh	25	48	difficult	difficult	JJ
cord-017954-vobslprh	25	49	and	and	CC
cord-017954-vobslprh	25	50	often	often	RB
cord-017954-vobslprh	25	51	rely	rely	VBP
cord-017954-vobslprh	25	52	on	on	IN
cord-017954-vobslprh	25	53	autopsy	autopsy	JJ
cord-017954-vobslprh	25	54	tissues	tissue	NNS
cord-017954-vobslprh	25	55	.	.	.
cord-017954-vobslprh	26	1	In	in	IN
cord-017954-vobslprh	26	2	these	these	DT
cord-017954-vobslprh	26	3	cases	case	NNS
cord-017954-vobslprh	26	4	,	,	,
cord-017954-vobslprh	26	5	patients	patient	NNS
cord-017954-vobslprh	26	6	might	may	MD
cord-017954-vobslprh	26	7	have	have	VB
cord-017954-vobslprh	26	8	had	have	VBN
cord-017954-vobslprh	26	9	the	the	DT
cord-017954-vobslprh	26	10	disease	disease	NN
cord-017954-vobslprh	26	11	for	for	IN
cord-017954-vobslprh	26	12	decades	decade	NNS
cord-017954-vobslprh	26	13	and	and	CC
cord-017954-vobslprh	26	14	therefore	therefore	RB
cord-017954-vobslprh	26	15	the	the	DT
cord-017954-vobslprh	26	16	tissues	tissue	NNS
cord-017954-vobslprh	26	17	are	be	VBP
cord-017954-vobslprh	26	18	representative	representative	JJ
cord-017954-vobslprh	26	19	of	of	IN
cord-017954-vobslprh	26	20	disease	disease	NN
cord-017954-vobslprh	26	21	at	at	IN
cord-017954-vobslprh	26	22	the	the	DT
cord-017954-vobslprh	26	23	end	end	NN
cord-017954-vobslprh	26	24	stage	stage	NN
cord-017954-vobslprh	26	25	.	.	.
cord-017954-vobslprh	27	1	Furthermore	furthermore	RB
cord-017954-vobslprh	27	2	,	,	,
cord-017954-vobslprh	27	3	epidemiological	epidemiological	JJ
cord-017954-vobslprh	27	4	studies	study	NNS
cord-017954-vobslprh	27	5	have	have	VBP
cord-017954-vobslprh	27	6	suggested	suggest	VBN
cord-017954-vobslprh	27	7	that	that	IN
cord-017954-vobslprh	27	8	the	the	DT
cord-017954-vobslprh	27	9	initiating	initiate	VBG
cord-017954-vobslprh	27	10	factors	factor	NNS
cord-017954-vobslprh	27	11	for	for	IN
cord-017954-vobslprh	27	12	MS	MS	NNP
cord-017954-vobslprh	27	13	might	may	MD
cord-017954-vobslprh	27	14	be	be	VB
cord-017954-vobslprh	27	15	infections	infection	NNS
cord-017954-vobslprh	27	16	that	that	WDT
cord-017954-vobslprh	27	17	occur	occur	VBP
cord-017954-vobslprh	27	18	during	during	IN
cord-017954-vobslprh	27	19	childhood	childhood	NN
cord-017954-vobslprh	27	20	[	[	-LRB-
cord-017954-vobslprh	27	21	5	5	CD
cord-017954-vobslprh	27	22	]	]	-RRB-
cord-017954-vobslprh	27	23	.	.	.
cord-017954-vobslprh	28	1	Therefore	therefore	RB
cord-017954-vobslprh	28	2	,	,	,
cord-017954-vobslprh	28	3	animal	animal	NN
cord-017954-vobslprh	28	4	models	model	NNS
cord-017954-vobslprh	28	5	of	of	IN
cord-017954-vobslprh	28	6	MS	MS	NNP
cord-017954-vobslprh	28	7	are	be	VBP
cord-017954-vobslprh	28	8	critical	critical	JJ
cord-017954-vobslprh	28	9	for	for	IN
cord-017954-vobslprh	28	10	the	the	DT
cord-017954-vobslprh	28	11	study	study	NN
cord-017954-vobslprh	28	12	of	of	IN
cord-017954-vobslprh	28	13	susceptibility	susceptibility	NN
cord-017954-vobslprh	28	14	,	,	,
cord-017954-vobslprh	28	15	disease	disease	NN
cord-017954-vobslprh	28	16	initiation	initiation	NN
cord-017954-vobslprh	28	17	,	,	,
cord-017954-vobslprh	28	18	and	and	CC
cord-017954-vobslprh	28	19	pathology	pathology	NN
cord-017954-vobslprh	28	20	during	during	IN
cord-017954-vobslprh	28	21	the	the	DT
cord-017954-vobslprh	28	22	early	early	JJ
cord-017954-vobslprh	28	23	stages	stage	NNS
cord-017954-vobslprh	28	24	of	of	IN
cord-017954-vobslprh	28	25	disease	disease	NN
cord-017954-vobslprh	28	26	.	.	.
cord-017954-vobslprh	29	1	Experimental	experimental	JJ
cord-017954-vobslprh	29	2	autoimmune	autoimmune	JJ
cord-017954-vobslprh	29	3	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	29	4	(	(	-LRB-
cord-017954-vobslprh	29	5	EAE	EAE	NNP
cord-017954-vobslprh	29	6	)	)	-RRB-
cord-017954-vobslprh	29	7	is	be	VBZ
cord-017954-vobslprh	29	8	an	an	DT
cord-017954-vobslprh	29	9	autoimmune	autoimmune	JJ
cord-017954-vobslprh	29	10	T	t	NN
cord-017954-vobslprh	29	11	cell	cell	NN
cord-017954-vobslprh	29	12	-	-	HYPH
cord-017954-vobslprh	29	13	mediated	mediate	VBN
cord-017954-vobslprh	29	14	disease	disease	NN
cord-017954-vobslprh	29	15	of	of	IN
cord-017954-vobslprh	29	16	the	the	DT
cord-017954-vobslprh	29	17	CNS	CNS	NNP
cord-017954-vobslprh	29	18	mediated	mediate	VBN
cord-017954-vobslprh	29	19	primarily	primarily	RB
cord-017954-vobslprh	29	20	by	by	IN
cord-017954-vobslprh	29	21	CD4þ	CD4þ	NNP
cord-017954-vobslprh	29	22	T	T	NNP
cord-017954-vobslprh	29	23	cells	cell	NNS
cord-017954-vobslprh	29	24	and	and	CC
cord-017954-vobslprh	29	25	a	a	DT
cord-017954-vobslprh	29	26	commonly	commonly	RB
cord-017954-vobslprh	29	27	used	use	VBN
cord-017954-vobslprh	29	28	animal	animal	NN
cord-017954-vobslprh	29	29	model	model	NN
cord-017954-vobslprh	29	30	for	for	IN
cord-017954-vobslprh	29	31	the	the	DT
cord-017954-vobslprh	29	32	study	study	NN
cord-017954-vobslprh	29	33	of	of	IN
cord-017954-vobslprh	29	34	MS	MS	NNP
cord-017954-vobslprh	29	35	.	.	.
cord-017954-vobslprh	30	1	Disease	Disease	NNP
cord-017954-vobslprh	30	2	is	be	VBZ
cord-017954-vobslprh	30	3	characterized	characterize	VBN
cord-017954-vobslprh	30	4	by	by	IN
cord-017954-vobslprh	30	5	perivascular	perivascular	JJ
cord-017954-vobslprh	30	6	lesions	lesion	NNS
cord-017954-vobslprh	30	7	containing	contain	VBG
cord-017954-vobslprh	30	8	inflammatory	inflammatory	JJ
cord-017954-vobslprh	30	9	infiltrates	infiltrate	NNS
cord-017954-vobslprh	30	10	and	and	CC
cord-017954-vobslprh	30	11	nerve	nerve	NN
cord-017954-vobslprh	30	12	conduction	conduction	NN
cord-017954-vobslprh	30	13	block	block	NN
cord-017954-vobslprh	30	14	that	that	WDT
cord-017954-vobslprh	30	15	causes	cause	VBZ
cord-017954-vobslprh	30	16	reversible	reversible	JJ
cord-017954-vobslprh	30	17	hind	hind	JJ
cord-017954-vobslprh	30	18	-	-	HYPH
cord-017954-vobslprh	30	19	limb	limb	NN
cord-017954-vobslprh	30	20	paralysis	paralysis	NN
cord-017954-vobslprh	30	21	.	.	.
cord-017954-vobslprh	31	1	In	in	IN
cord-017954-vobslprh	31	2	addition	addition	NN
cord-017954-vobslprh	31	3	,	,	,
cord-017954-vobslprh	31	4	late	late	JJ
cord-017954-vobslprh	31	5	-	-	HYPH
cord-017954-vobslprh	31	6	stage	stage	NN
cord-017954-vobslprh	31	7	EAE	EAE	NNP
cord-017954-vobslprh	31	8	animals	animal	NNS
cord-017954-vobslprh	31	9	also	also	RB
cord-017954-vobslprh	31	10	develop	develop	VBP
cord-017954-vobslprh	31	11	axonal	axonal	JJ
cord-017954-vobslprh	31	12	demyelination	demyelination	NN
cord-017954-vobslprh	31	13	and	and	CC
cord-017954-vobslprh	31	14	loss	loss	NN
cord-017954-vobslprh	31	15	,	,	,
cord-017954-vobslprh	31	16	a	a	DT
cord-017954-vobslprh	31	17	pathological	pathological	JJ
cord-017954-vobslprh	31	18	hallmark	hallmark	NN
cord-017954-vobslprh	31	19	of	of	IN
cord-017954-vobslprh	31	20	MS	MS	NNP
cord-017954-vobslprh	31	21	,	,	,
cord-017954-vobslprh	31	22	which	which	WDT
cord-017954-vobslprh	31	23	leads	lead	VBZ
cord-017954-vobslprh	31	24	to	to	IN
cord-017954-vobslprh	31	25	severe	severe	JJ
cord-017954-vobslprh	31	26	permanent	permanent	JJ
cord-017954-vobslprh	31	27	disability	disability	NN
cord-017954-vobslprh	31	28	.	.	.
cord-017954-vobslprh	32	1	Characterization	characterization	NN
cord-017954-vobslprh	32	2	of	of	IN
cord-017954-vobslprh	32	3	the	the	DT
cord-017954-vobslprh	32	4	immune	immune	JJ
cord-017954-vobslprh	32	5	cell	cell	NN
cord-017954-vobslprh	32	6	infiltrate	infiltrate	NN
cord-017954-vobslprh	32	7	(	(	-LRB-
cord-017954-vobslprh	32	8	T	t	NN
cord-017954-vobslprh	32	9	cells	cell	NNS
cord-017954-vobslprh	32	10	,	,	,
cord-017954-vobslprh	32	11	B	b	NN
cord-017954-vobslprh	32	12	cells	cell	NNS
cord-017954-vobslprh	32	13	,	,	,
cord-017954-vobslprh	32	14	activated	activate	VBN
cord-017954-vobslprh	32	15	macrophages	macrophage	NNS
cord-017954-vobslprh	32	16	,	,	,
cord-017954-vobslprh	32	17	and	and	CC
cord-017954-vobslprh	32	18	microglia	microglia	NNP
cord-017954-vobslprh	32	19	)	)	-RRB-
cord-017954-vobslprh	32	20	and	and	CC
cord-017954-vobslprh	32	21	the	the	DT
cord-017954-vobslprh	32	22	pathology	pathology	NN
cord-017954-vobslprh	32	23	of	of	IN
cord-017954-vobslprh	32	24	perivascular	perivascular	JJ
cord-017954-vobslprh	32	25	demyelinating	demyelinating	JJ
cord-017954-vobslprh	32	26	lesions	lesion	NNS
cord-017954-vobslprh	32	27	have	have	VBP
cord-017954-vobslprh	32	28	shown	show	VBN
cord-017954-vobslprh	32	29	similarities	similarity	NNS
cord-017954-vobslprh	32	30	with	with	IN
cord-017954-vobslprh	32	31	human	human	JJ
cord-017954-vobslprh	32	32	MS	MS	NNP
cord-017954-vobslprh	32	33	lesions	lesion	NNS
cord-017954-vobslprh	32	34	[	[	-LRB-
cord-017954-vobslprh	32	35	6	6	CD
cord-017954-vobslprh	32	36	,	,	,
cord-017954-vobslprh	32	37	7	7	CD
cord-017954-vobslprh	32	38	]	]	-RRB-
cord-017954-vobslprh	32	39	although	although	IN
cord-017954-vobslprh	32	40	in	in	IN
cord-017954-vobslprh	32	41	EAE	EAE	NNP
cord-017954-vobslprh	32	42	the	the	DT
cord-017954-vobslprh	32	43	spinal	spinal	JJ
cord-017954-vobslprh	32	44	cord	cord	NN
cord-017954-vobslprh	32	45	is	be	VBZ
cord-017954-vobslprh	32	46	the	the	DT
cord-017954-vobslprh	32	47	target	target	NN
cord-017954-vobslprh	32	48	organ	organ	NN
cord-017954-vobslprh	32	49	,	,	,
cord-017954-vobslprh	32	50	whereas	whereas	IN
cord-017954-vobslprh	32	51	in	in	IN
cord-017954-vobslprh	32	52	MS	MS	NNP
cord-017954-vobslprh	32	53	the	the	DT
cord-017954-vobslprh	32	54	brain	brain	NN
cord-017954-vobslprh	32	55	is	be	VBZ
cord-017954-vobslprh	32	56	more	more	RBR
cord-017954-vobslprh	32	57	often	often	RB
cord-017954-vobslprh	32	58	targeted	target	VBN
cord-017954-vobslprh	32	59	,	,	,
cord-017954-vobslprh	32	60	especially	especially	RB
cord-017954-vobslprh	32	61	the	the	DT
cord-017954-vobslprh	32	62	white	white	JJ
cord-017954-vobslprh	32	63	matter	matter	NN
cord-017954-vobslprh	32	64	.	.	.
cord-017954-vobslprh	33	1	However	however	RB
cord-017954-vobslprh	33	2	,	,	,
cord-017954-vobslprh	33	3	EAE	EAE	NNP
cord-017954-vobslprh	33	4	is	be	VBZ
cord-017954-vobslprh	33	5	a	a	DT
cord-017954-vobslprh	33	6	useful	useful	JJ
cord-017954-vobslprh	33	7	model	model	NN
cord-017954-vobslprh	33	8	to	to	TO
cord-017954-vobslprh	33	9	study	study	VB
cord-017954-vobslprh	33	10	the	the	DT
cord-017954-vobslprh	33	11	inflammatory	inflammatory	JJ
cord-017954-vobslprh	33	12	stage	stage	NN
cord-017954-vobslprh	33	13	of	of	IN
cord-017954-vobslprh	33	14	MS	MS	NNP
cord-017954-vobslprh	33	15	and	and	CC
cord-017954-vobslprh	33	16	shares	share	NNS
cord-017954-vobslprh	33	17	some	some	DT
cord-017954-vobslprh	33	18	characteristics	characteristic	NNS
cord-017954-vobslprh	33	19	of	of	IN
cord-017954-vobslprh	33	20	MS	MS	NNP
cord-017954-vobslprh	33	21	such	such	JJ
cord-017954-vobslprh	33	22	as	as	IN
cord-017954-vobslprh	33	23	optic	optic	JJ
cord-017954-vobslprh	33	24	neuritis	neuritis	NN
cord-017954-vobslprh	33	25	,	,	,
cord-017954-vobslprh	33	26	increased	increase	VBN
cord-017954-vobslprh	33	27	susceptibility	susceptibility	NN
cord-017954-vobslprh	33	28	of	of	IN
cord-017954-vobslprh	33	29	females	female	NNS
cord-017954-vobslprh	33	30	,	,	,
cord-017954-vobslprh	33	31	perivascular	perivascular	JJ
cord-017954-vobslprh	33	32	lesions	lesion	NNS
cord-017954-vobslprh	33	33	,	,	,
cord-017954-vobslprh	33	34	axonal	axonal	JJ
cord-017954-vobslprh	33	35	demyelination	demyelination	NN
cord-017954-vobslprh	33	36	,	,	,
cord-017954-vobslprh	33	37	and	and	CC
cord-017954-vobslprh	33	38	partial	partial	JJ
cord-017954-vobslprh	33	39	remyelination	remyelination	NN
cord-017954-vobslprh	33	40	,	,	,
cord-017954-vobslprh	33	41	as	as	RB
cord-017954-vobslprh	33	42	well	well	RB
cord-017954-vobslprh	33	43	as	as	IN
cord-017954-vobslprh	33	44	eventual	eventual	JJ
cord-017954-vobslprh	33	45	axonal	axonal	JJ
cord-017954-vobslprh	33	46	loss	loss	NN
cord-017954-vobslprh	33	47	and	and	CC
cord-017954-vobslprh	33	48	flaccid	flaccid	JJ
cord-017954-vobslprh	33	49	-	-	HYPH
cord-017954-vobslprh	33	50	limb	limb	NN
cord-017954-vobslprh	33	51	paralysis	paralysis	NN
cord-017954-vobslprh	33	52	.	.	.
cord-017954-vobslprh	34	1	There	there	EX
cord-017954-vobslprh	34	2	are	be	VBP
cord-017954-vobslprh	34	3	two	two	CD
cord-017954-vobslprh	34	4	commonly	commonly	RB
cord-017954-vobslprh	34	5	used	use	VBN
cord-017954-vobslprh	34	6	models	model	NNS
cord-017954-vobslprh	34	7	of	of	IN
cord-017954-vobslprh	34	8	EAE	EAE	NNP
cord-017954-vobslprh	34	9	.	.	.
cord-017954-vobslprh	35	1	Active	active	JJ
cord-017954-vobslprh	35	2	EAE	EAE	NNP
cord-017954-vobslprh	35	3	is	be	VBZ
cord-017954-vobslprh	35	4	induced	induce	VBN
cord-017954-vobslprh	35	5	by	by	IN
cord-017954-vobslprh	35	6	subcutaneously	subcutaneously	RB
cord-017954-vobslprh	35	7	immunizing	immunize	VBG
cord-017954-vobslprh	35	8	genetically	genetically	RB
cord-017954-vobslprh	35	9	susceptible	susceptible	JJ
cord-017954-vobslprh	35	10	animals	animal	NNS
cord-017954-vobslprh	35	11	,	,	,
cord-017954-vobslprh	35	12	usually	usually	RB
cord-017954-vobslprh	35	13	rodents	rodent	NNS
cord-017954-vobslprh	35	14	,	,	,
cord-017954-vobslprh	35	15	with	with	IN
cord-017954-vobslprh	35	16	myelin	myelin	NN
cord-017954-vobslprh	35	17	antigen	antigen	NN
cord-017954-vobslprh	35	18	in	in	IN
cord-017954-vobslprh	35	19	Freund	Freund	NNP
cord-017954-vobslprh	35	20	's	's	POS
cord-017954-vobslprh	35	21	complete	complete	JJ
cord-017954-vobslprh	35	22	adjuvant	adjuvant	NN
cord-017954-vobslprh	35	23	-	-	HYPH
cord-017954-vobslprh	35	24	containing	contain	VBG
cord-017954-vobslprh	35	25	mineral	mineral	NN
cord-017954-vobslprh	35	26	oil	oil	NN
cord-017954-vobslprh	35	27	and	and	CC
cord-017954-vobslprh	35	28	Mycobacterium	Mycobacterium	NNP
cord-017954-vobslprh	35	29	tuberculosis	tuberculosis	NN
cord-017954-vobslprh	35	30	strain	strain	VBP
cord-017954-vobslprh	35	31	H37RA	h37ra	NN
cord-017954-vobslprh	35	32	.	.	.
cord-017954-vobslprh	36	1	In	in	IN
cord-017954-vobslprh	36	2	some	some	DT
cord-017954-vobslprh	36	3	EAE	EAE	NNP
cord-017954-vobslprh	36	4	low	low	JJ
cord-017954-vobslprh	36	5	-	-	HYPH
cord-017954-vobslprh	36	6	responder	responder	NN
cord-017954-vobslprh	36	7	mouse	mouse	NN
cord-017954-vobslprh	36	8	strains	strain	NNS
cord-017954-vobslprh	36	9	,	,	,
cord-017954-vobslprh	36	10	such	such	JJ
cord-017954-vobslprh	36	11	as	as	IN
cord-017954-vobslprh	36	12	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	36	13	,	,	,
cord-017954-vobslprh	36	14	additional	additional	JJ
cord-017954-vobslprh	36	15	injections	injection	NNS
cord-017954-vobslprh	36	16	of	of	IN
cord-017954-vobslprh	36	17	pertussis	pertussis	NN
cord-017954-vobslprh	36	18	toxin	toxin	NN
cord-017954-vobslprh	36	19	are	be	VBP
cord-017954-vobslprh	36	20	required	require	VBN
cord-017954-vobslprh	36	21	.	.	.
cord-017954-vobslprh	37	1	During	during	IN
cord-017954-vobslprh	37	2	the	the	DT
cord-017954-vobslprh	37	3	induction	induction	NN
cord-017954-vobslprh	37	4	phase	phase	NN
cord-017954-vobslprh	37	5	,	,	,
cord-017954-vobslprh	37	6	myelin	myelin	NN
cord-017954-vobslprh	37	7	-	-	HYPH
cord-017954-vobslprh	37	8	specific	specific	JJ
cord-017954-vobslprh	37	9	T	t	NN
cord-017954-vobslprh	37	10	cells	cell	NNS
cord-017954-vobslprh	37	11	are	be	VBP
cord-017954-vobslprh	37	12	activated	activate	VBN
cord-017954-vobslprh	37	13	by	by	IN
cord-017954-vobslprh	37	14	antigen	antigen	NN
cord-017954-vobslprh	37	15	-	-	HYPH
cord-017954-vobslprh	37	16	presenting	present	VBG
cord-017954-vobslprh	37	17	cells	cell	NNS
cord-017954-vobslprh	37	18	(	(	-LRB-
cord-017954-vobslprh	37	19	APC	APC	NNP
cord-017954-vobslprh	37	20	)	)	-RRB-
cord-017954-vobslprh	37	21	presenting	present	VBG
cord-017954-vobslprh	37	22	myelin	myelin	JJ
cord-017954-vobslprh	37	23	peptide	peptide	NN
cord-017954-vobslprh	37	24	fragments	fragment	NNS
cord-017954-vobslprh	37	25	in	in	IN
cord-017954-vobslprh	37	26	the	the	DT
cord-017954-vobslprh	37	27	draining	drain	VBG
cord-017954-vobslprh	37	28	lymph	lymph	NN
cord-017954-vobslprh	37	29	nodes	node	NNS
cord-017954-vobslprh	37	30	to	to	TO
cord-017954-vobslprh	37	31	produce	produce	VB
cord-017954-vobslprh	37	32	T	T	NNP
cord-017954-vobslprh	37	33	helper	helper	NN
cord-017954-vobslprh	37	34	1	1	CD
cord-017954-vobslprh	37	35	(	(	-LRB-
cord-017954-vobslprh	37	36	Th1	Th1	NNP
cord-017954-vobslprh	37	37	)	)	-RRB-
cord-017954-vobslprh	37	38	type	type	NN
cord-017954-vobslprh	37	39	cytokines	cytokine	NNS
cord-017954-vobslprh	37	40	,	,	,
cord-017954-vobslprh	37	41	such	such	JJ
cord-017954-vobslprh	37	42	as	as	IN
cord-017954-vobslprh	37	43	interferon	interferon	NN
cord-017954-vobslprh	37	44	(	(	-LRB-
cord-017954-vobslprh	37	45	IFN)-γ	ifn)-γ	NN
cord-017954-vobslprh	37	46	and	and	CC
cord-017954-vobslprh	37	47	tumour	tumour	NN
cord-017954-vobslprh	37	48	necrosis	necrosis	NN
cord-017954-vobslprh	37	49	factor	factor	NN
cord-017954-vobslprh	37	50	(	(	-LRB-
cord-017954-vobslprh	37	51	TNF)-α	TNF)-α	NNP
cord-017954-vobslprh	37	52	,	,	,
cord-017954-vobslprh	37	53	which	which	WDT
cord-017954-vobslprh	37	54	allows	allow	VBZ
cord-017954-vobslprh	37	55	them	-PRON-	PRP
cord-017954-vobslprh	37	56	to	to	TO
cord-017954-vobslprh	37	57	escape	escape	VB
cord-017954-vobslprh	37	58	the	the	DT
cord-017954-vobslprh	37	59	lymph	lymph	NN
cord-017954-vobslprh	37	60	nodes	node	NNS
cord-017954-vobslprh	37	61	and	and	CC
cord-017954-vobslprh	37	62	traffic	traffic	NN
cord-017954-vobslprh	37	63	to	to	IN
cord-017954-vobslprh	37	64	the	the	DT
cord-017954-vobslprh	37	65	CNS	CNS	NNP
cord-017954-vobslprh	37	66	.	.	.
cord-017954-vobslprh	38	1	The	the	DT
cord-017954-vobslprh	38	2	effector	effector	JJ
cord-017954-vobslprh	38	3	phase	phase	NN
cord-017954-vobslprh	38	4	of	of	IN
cord-017954-vobslprh	38	5	disease	disease	NN
cord-017954-vobslprh	38	6	involves	involve	VBZ
cord-017954-vobslprh	38	7	the	the	DT
cord-017954-vobslprh	38	8	extravasation	extravasation	NN
cord-017954-vobslprh	38	9	of	of	IN
cord-017954-vobslprh	38	10	activated	activate	VBN
cord-017954-vobslprh	38	11	myelinspecific	myelinspecific	NN
cord-017954-vobslprh	38	12	T	t	NN
cord-017954-vobslprh	38	13	cells	cell	NNS
cord-017954-vobslprh	38	14	through	through	IN
cord-017954-vobslprh	38	15	the	the	DT
cord-017954-vobslprh	38	16	blood	blood	NN
cord-017954-vobslprh	38	17	-	-	HYPH
cord-017954-vobslprh	38	18	brain	brain	NN
cord-017954-vobslprh	38	19	barrier	barrier	NN
cord-017954-vobslprh	38	20	and	and	CC
cord-017954-vobslprh	38	21	into	into	IN
cord-017954-vobslprh	38	22	perivascular	perivascular	JJ
cord-017954-vobslprh	38	23	spaces	space	NNS
cord-017954-vobslprh	38	24	in	in	IN
cord-017954-vobslprh	38	25	the	the	DT
cord-017954-vobslprh	38	26	spinal	spinal	JJ
cord-017954-vobslprh	38	27	cord	cord	NN
cord-017954-vobslprh	38	28	.	.	.
cord-017954-vobslprh	39	1	Here	here	RB
cord-017954-vobslprh	39	2	,	,	,
cord-017954-vobslprh	39	3	the	the	DT
cord-017954-vobslprh	39	4	encephalitogenic	encephalitogenic	NNP
cord-017954-vobslprh	39	5	T	T	NNP
cord-017954-vobslprh	39	6	cells	cell	NNS
cord-017954-vobslprh	39	7	encounter	encounter	VBP
cord-017954-vobslprh	39	8	CNS	CNS	NNP
cord-017954-vobslprh	39	9	-	-	HYPH
cord-017954-vobslprh	39	10	resident	resident	NN
cord-017954-vobslprh	39	11	cells	cell	NNS
cord-017954-vobslprh	39	12	mediating	mediate	VBG
cord-017954-vobslprh	39	13	further	further	JJ
cord-017954-vobslprh	39	14	stimulation	stimulation	NN
cord-017954-vobslprh	39	15	of	of	IN
cord-017954-vobslprh	39	16	pro	pro	JJ
cord-017954-vobslprh	39	17	-	-	JJ
cord-017954-vobslprh	39	18	inflammatory	inflammatory	JJ
cord-017954-vobslprh	39	19	cytokines	cytokine	NNS
cord-017954-vobslprh	39	20	and	and	CC
cord-017954-vobslprh	39	21	chemokines	chemokine	NNS
cord-017954-vobslprh	39	22	that	that	WDT
cord-017954-vobslprh	39	23	mediate	mediate	VBP
cord-017954-vobslprh	39	24	a	a	DT
cord-017954-vobslprh	39	25	secondary	secondary	JJ
cord-017954-vobslprh	39	26	influx	influx	NN
cord-017954-vobslprh	39	27	of	of	IN
cord-017954-vobslprh	39	28	other	other	JJ
cord-017954-vobslprh	39	29	peripheral	peripheral	JJ
cord-017954-vobslprh	39	30	inflammatory	inflammatory	JJ
cord-017954-vobslprh	39	31	cells	cell	NNS
cord-017954-vobslprh	39	32	including	include	VBG
cord-017954-vobslprh	39	33	B	b	NN
cord-017954-vobslprh	39	34	cells	cell	NNS
cord-017954-vobslprh	39	35	and	and	CC
cord-017954-vobslprh	39	36	mononuclear	mononuclear	JJ
cord-017954-vobslprh	39	37	phagocytes	phagocyte	NNS
cord-017954-vobslprh	39	38	.	.	.
cord-017954-vobslprh	40	1	A	a	DT
cord-017954-vobslprh	40	2	study	study	NN
cord-017954-vobslprh	40	3	in	in	IN
cord-017954-vobslprh	40	4	EAE	EAE	NNP
cord-017954-vobslprh	40	5	and	and	CC
cord-017954-vobslprh	40	6	a	a	DT
cord-017954-vobslprh	40	7	viral	viral	JJ
cord-017954-vobslprh	40	8	model	model	NN
cord-017954-vobslprh	40	9	of	of	IN
cord-017954-vobslprh	40	10	MS	MS	NNP
cord-017954-vobslprh	40	11	demonstrated	demonstrate	VBD
cord-017954-vobslprh	40	12	that	that	IN
cord-017954-vobslprh	40	13	APCs	apc	NNS
cord-017954-vobslprh	40	14	in	in	IN
cord-017954-vobslprh	40	15	the	the	DT
cord-017954-vobslprh	40	16	CNS	CNS	NNP
cord-017954-vobslprh	40	17	restimulated	restimulate	VBD
cord-017954-vobslprh	40	18	myelin	myelin	NN
cord-017954-vobslprh	40	19	-	-	HYPH
cord-017954-vobslprh	40	20	specific	specific	JJ
cord-017954-vobslprh	40	21	T	t	NN
cord-017954-vobslprh	40	22	cells	cell	NNS
cord-017954-vobslprh	40	23	to	to	TO
cord-017954-vobslprh	40	24	initiate	initiate	VB
cord-017954-vobslprh	40	25	epitope	epitope	NN
cord-017954-vobslprh	40	26	spreading	spread	VBG
cord-017954-vobslprh	40	27	to	to	IN
cord-017954-vobslprh	40	28	other	other	JJ
cord-017954-vobslprh	40	29	myelin	myelin	NN
cord-017954-vobslprh	40	30	antigens	antigen	NNS
cord-017954-vobslprh	40	31	and	and	CC
cord-017954-vobslprh	40	32	perpetuate	perpetuate	VB
cord-017954-vobslprh	40	33	disease	disease	NN
cord-017954-vobslprh	40	34	[	[	-LRB-
cord-017954-vobslprh	40	35	8	8	CD
cord-017954-vobslprh	40	36	]	]	-RRB-
cord-017954-vobslprh	40	37	.	.	.
cord-017954-vobslprh	41	1	The	the	DT
cord-017954-vobslprh	41	2	consequence	consequence	NN
cord-017954-vobslprh	41	3	of	of	IN
cord-017954-vobslprh	41	4	this	this	DT
cord-017954-vobslprh	41	5	pro	pro	JJ
cord-017954-vobslprh	41	6	-	-	JJ
cord-017954-vobslprh	41	7	inflammatory	inflammatory	JJ
cord-017954-vobslprh	41	8	cytokine	cytokine	NN
cord-017954-vobslprh	41	9	milieu	milieu	NN
cord-017954-vobslprh	41	10	is	be	VBZ
cord-017954-vobslprh	41	11	the	the	DT
cord-017954-vobslprh	41	12	demyelination	demyelination	NN
cord-017954-vobslprh	41	13	of	of	IN
cord-017954-vobslprh	41	14	CNS	CNS	NNP
cord-017954-vobslprh	41	15	axons	axon	NNS
cord-017954-vobslprh	41	16	,	,	,
cord-017954-vobslprh	41	17	thought	think	VBD
cord-017954-vobslprh	41	18	to	to	TO
cord-017954-vobslprh	41	19	be	be	VB
cord-017954-vobslprh	41	20	mediated	mediate	VBN
cord-017954-vobslprh	41	21	in	in	IN
cord-017954-vobslprh	41	22	part	part	NN
cord-017954-vobslprh	41	23	by	by	IN
cord-017954-vobslprh	41	24	numerous	numerous	JJ
cord-017954-vobslprh	41	25	mechanisms	mechanism	NNS
cord-017954-vobslprh	41	26	including	include	VBG
cord-017954-vobslprh	41	27	phagocytosis	phagocytosis	NN
cord-017954-vobslprh	41	28	by	by	IN
cord-017954-vobslprh	41	29	activated	activate	VBN
cord-017954-vobslprh	41	30	mononuclear	mononuclear	JJ
cord-017954-vobslprh	41	31	cells	cell	NNS
cord-017954-vobslprh	41	32	,	,	,
cord-017954-vobslprh	41	33	destructive	destructive	JJ
cord-017954-vobslprh	41	34	effects	effect	NNS
cord-017954-vobslprh	41	35	of	of	IN
cord-017954-vobslprh	41	36	anti	anti	JJ
cord-017954-vobslprh	41	37	-	-	JJ
cord-017954-vobslprh	41	38	myelin	myelin	JJ
cord-017954-vobslprh	41	39	antibodies	antibody	NNS
cord-017954-vobslprh	41	40	,	,	,
cord-017954-vobslprh	41	41	the	the	DT
cord-017954-vobslprh	41	42	production	production	NN
cord-017954-vobslprh	41	43	of	of	IN
cord-017954-vobslprh	41	44	free	free	JJ
cord-017954-vobslprh	41	45	radicals	radical	NNS
cord-017954-vobslprh	41	46	,	,	,
cord-017954-vobslprh	41	47	and	and	CC
cord-017954-vobslprh	41	48	the	the	DT
cord-017954-vobslprh	41	49	direct	direct	JJ
cord-017954-vobslprh	41	50	cytotoxic	cytotoxic	JJ
cord-017954-vobslprh	41	51	effects	effect	NNS
cord-017954-vobslprh	41	52	of	of	IN
cord-017954-vobslprh	41	53	pro	pro	JJ
cord-017954-vobslprh	41	54	-	-	JJ
cord-017954-vobslprh	41	55	inflammatory	inflammatory	JJ
cord-017954-vobslprh	41	56	cytokines	cytokine	NNS
cord-017954-vobslprh	41	57	secreted	secrete	VBN
cord-017954-vobslprh	41	58	by	by	IN
cord-017954-vobslprh	41	59	activated	activate	VBN
cord-017954-vobslprh	41	60	CD4þ	CD4þ	NNP
cord-017954-vobslprh	41	61	T	T	NNP
cord-017954-vobslprh	41	62	cells	cell	NNS
cord-017954-vobslprh	41	63	and	and	CC
cord-017954-vobslprh	41	64	monocytes	monocyte	NNS
cord-017954-vobslprh	41	65	.	.	.
cord-017954-vobslprh	42	1	Initially	initially	RB
cord-017954-vobslprh	42	2	guinea	guinea	NN
cord-017954-vobslprh	42	3	pigs	pig	NNS
cord-017954-vobslprh	42	4	and	and	CC
cord-017954-vobslprh	42	5	rats	rat	NNS
cord-017954-vobslprh	42	6	were	be	VBD
cord-017954-vobslprh	42	7	the	the	DT
cord-017954-vobslprh	42	8	animals	animal	NNS
cord-017954-vobslprh	42	9	of	of	IN
cord-017954-vobslprh	42	10	choice	choice	NN
cord-017954-vobslprh	42	11	for	for	IN
cord-017954-vobslprh	42	12	EAE	EAE	NNP
cord-017954-vobslprh	42	13	studies	study	NNS
cord-017954-vobslprh	42	14	.	.	.
cord-017954-vobslprh	43	1	However	however	RB
cord-017954-vobslprh	43	2	,	,	,
cord-017954-vobslprh	43	3	with	with	IN
cord-017954-vobslprh	43	4	the	the	DT
cord-017954-vobslprh	43	5	advent	advent	NN
cord-017954-vobslprh	43	6	of	of	IN
cord-017954-vobslprh	43	7	transgenic	transgenic	JJ
cord-017954-vobslprh	43	8	and	and	CC
cord-017954-vobslprh	43	9	gene	gene	NN
cord-017954-vobslprh	43	10	knockout	knockout	NN
cord-017954-vobslprh	43	11	technology	technology	NN
cord-017954-vobslprh	43	12	,	,	,
cord-017954-vobslprh	43	13	mice	mouse	NNS
cord-017954-vobslprh	43	14	have	have	VBP
cord-017954-vobslprh	43	15	become	become	VBN
cord-017954-vobslprh	43	16	the	the	DT
cord-017954-vobslprh	43	17	more	more	RBR
cord-017954-vobslprh	43	18	commonly	commonly	RB
cord-017954-vobslprh	43	19	used	use	VBN
cord-017954-vobslprh	43	20	animal	animal	NN
cord-017954-vobslprh	43	21	for	for	IN
cord-017954-vobslprh	43	22	EAE	EAE	NNP
cord-017954-vobslprh	43	23	studies	study	NNS
cord-017954-vobslprh	43	24	.	.	.
cord-017954-vobslprh	44	1	Numerous	numerous	JJ
cord-017954-vobslprh	44	2	mouse	mouse	NN
cord-017954-vobslprh	44	3	models	model	NNS
cord-017954-vobslprh	44	4	of	of	IN
cord-017954-vobslprh	44	5	EAE	EAE	NNP
cord-017954-vobslprh	44	6	have	have	VBP
cord-017954-vobslprh	44	7	been	be	VBN
cord-017954-vobslprh	44	8	developed	develop	VBN
cord-017954-vobslprh	44	9	,	,	,
cord-017954-vobslprh	44	10	and	and	CC
cord-017954-vobslprh	44	11	these	these	DT
cord-017954-vobslprh	44	12	are	be	VBP
cord-017954-vobslprh	44	13	differentiated	differentiate	VBN
cord-017954-vobslprh	44	14	by	by	IN
cord-017954-vobslprh	44	15	the	the	DT
cord-017954-vobslprh	44	16	strain	strain	NN
cord-017954-vobslprh	44	17	of	of	IN
cord-017954-vobslprh	44	18	mouse	mouse	NN
cord-017954-vobslprh	44	19	used	use	VBN
cord-017954-vobslprh	44	20	and	and	CC
cord-017954-vobslprh	44	21	the	the	DT
cord-017954-vobslprh	44	22	immunodominant	immunodominant	JJ
cord-017954-vobslprh	44	23	myelin	myelin	NN
cord-017954-vobslprh	44	24	peptide	peptide	NN
cord-017954-vobslprh	44	25	for	for	IN
cord-017954-vobslprh	44	26	that	that	DT
cord-017954-vobslprh	44	27	particular	particular	JJ
cord-017954-vobslprh	44	28	strain	strain	NN
cord-017954-vobslprh	44	29	.	.	.
cord-017954-vobslprh	45	1	Commonly	commonly	RB
cord-017954-vobslprh	45	2	used	use	VBN
cord-017954-vobslprh	45	3	EAE	EAE	NNP
cord-017954-vobslprh	45	4	-	-	HYPH
cord-017954-vobslprh	45	5	susceptible	susceptible	JJ
cord-017954-vobslprh	45	6	mouse	mouse	NN
cord-017954-vobslprh	45	7	strains	strain	NNS
cord-017954-vobslprh	45	8	include	include	VBP
cord-017954-vobslprh	45	9	SJL	SJL	NNP
cord-017954-vobslprh	45	10	,	,	,
cord-017954-vobslprh	45	11	B10.PL	B10.PL	NNP
cord-017954-vobslprh	45	12	,	,	,
cord-017954-vobslprh	45	13	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	45	14	,	,	,
cord-017954-vobslprh	45	15	C3H	C3H	NNP
cord-017954-vobslprh	45	16	,	,	,
cord-017954-vobslprh	45	17	SWR	SWR	NNP
cord-017954-vobslprh	45	18	,	,	,
cord-017954-vobslprh	45	19	and	and	CC
cord-017954-vobslprh	45	20	Biozzi	Biozzi	NNP
cord-017954-vobslprh	45	21	ABH	ABH	NNP
cord-017954-vobslprh	45	22	.	.	.
cord-017954-vobslprh	46	1	Depending	depend	VBG
cord-017954-vobslprh	46	2	upon	upon	IN
cord-017954-vobslprh	46	3	the	the	DT
cord-017954-vobslprh	46	4	immunizing	immunize	VBG
cord-017954-vobslprh	46	5	myelin	myelin	NN
cord-017954-vobslprh	46	6	antigen	antigen	NN
cord-017954-vobslprh	46	7	and	and	CC
cord-017954-vobslprh	46	8	mouse	mouse	NN
cord-017954-vobslprh	46	9	strain	strain	NN
cord-017954-vobslprh	46	10	used	use	VBN
cord-017954-vobslprh	46	11	,	,	,
cord-017954-vobslprh	46	12	different	different	JJ
cord-017954-vobslprh	46	13	forms	form	NNS
cord-017954-vobslprh	46	14	of	of	IN
cord-017954-vobslprh	46	15	EAE	EAE	NNP
cord-017954-vobslprh	46	16	can	can	MD
cord-017954-vobslprh	46	17	be	be	VB
cord-017954-vobslprh	46	18	induced	induce	VBN
cord-017954-vobslprh	46	19	.	.	.
cord-017954-vobslprh	47	1	The	the	DT
cord-017954-vobslprh	47	2	most	most	RBS
cord-017954-vobslprh	47	3	commonly	commonly	RB
cord-017954-vobslprh	47	4	used	use	VBN
cord-017954-vobslprh	47	5	models	model	NNS
cord-017954-vobslprh	47	6	are	be	VBP
cord-017954-vobslprh	47	7	SJL	SJL	NNP
cord-017954-vobslprh	47	8	mice	mouse	NNS
cord-017954-vobslprh	47	9	immunized	immunize	VBN
cord-017954-vobslprh	47	10	with	with	IN
cord-017954-vobslprh	47	11	proteolipid	proteolipid	NN
cord-017954-vobslprh	47	12	protein	protein	NN
cord-017954-vobslprh	47	13	(	(	-LRB-
cord-017954-vobslprh	47	14	PLP	PLP	NNP
cord-017954-vobslprh	47	15	)	)	-RRB-
cord-017954-vobslprh	48	1	139	139	CD
cord-017954-vobslprh	48	2	-	-	SYM
cord-017954-vobslprh	48	3	151	151	CD
cord-017954-vobslprh	48	4	that	that	WDT
cord-017954-vobslprh	48	5	induces	induce	VBZ
cord-017954-vobslprh	48	6	a	a	DT
cord-017954-vobslprh	48	7	relapsing	relapse	VBG
cord-017954-vobslprh	48	8	-	-	HYPH
cord-017954-vobslprh	48	9	remitting	remit	VBG
cord-017954-vobslprh	48	10	form	form	NN
cord-017954-vobslprh	48	11	of	of	IN
cord-017954-vobslprh	48	12	disease	disease	NN
cord-017954-vobslprh	48	13	,	,	,
cord-017954-vobslprh	48	14	the	the	DT
cord-017954-vobslprh	48	15	most	most	RBS
cord-017954-vobslprh	48	16	common	common	JJ
cord-017954-vobslprh	48	17	form	form	NN
cord-017954-vobslprh	48	18	of	of	IN
cord-017954-vobslprh	48	19	MS	MS	NNP
cord-017954-vobslprh	48	20	,	,	,
cord-017954-vobslprh	48	21	and	and	CC
cord-017954-vobslprh	48	22	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	48	23	mice	mouse	NNS
cord-017954-vobslprh	48	24	immunized	immunize	VBN
cord-017954-vobslprh	48	25	with	with	IN
cord-017954-vobslprh	48	26	myelin	myelin	NN
cord-017954-vobslprh	48	27	oligodendrocyte	oligodendrocyte	NNP
cord-017954-vobslprh	48	28	protein	protein	NNP
cord-017954-vobslprh	48	29	(	(	-LRB-
cord-017954-vobslprh	48	30	MOG	MOG	NNP
cord-017954-vobslprh	48	31	)	)	-RRB-
cord-017954-vobslprh	49	1	35	35	CD
cord-017954-vobslprh	49	2	-	-	SYM
cord-017954-vobslprh	49	3	55	55	CD
cord-017954-vobslprh	49	4	that	that	WDT
cord-017954-vobslprh	49	5	initiates	initiate	VBZ
cord-017954-vobslprh	49	6	a	a	DT
cord-017954-vobslprh	49	7	chronic	chronic	JJ
cord-017954-vobslprh	49	8	-	-	HYPH
cord-017954-vobslprh	49	9	progressive	progressive	JJ
cord-017954-vobslprh	49	10	type	type	NN
cord-017954-vobslprh	49	11	of	of	IN
cord-017954-vobslprh	49	12	EAE	EAE	NNP
cord-017954-vobslprh	49	13	.	.	.
cord-017954-vobslprh	50	1	Other	other	JJ
cord-017954-vobslprh	50	2	strains	strain	NNS
cord-017954-vobslprh	50	3	,	,	,
cord-017954-vobslprh	50	4	such	such	JJ
cord-017954-vobslprh	50	5	as	as	IN
cord-017954-vobslprh	50	6	Biozzi	Biozzi	NNP
cord-017954-vobslprh	50	7	ABH	ABH	NNP
cord-017954-vobslprh	50	8	mice	mouse	NNS
cord-017954-vobslprh	50	9	,	,	,
cord-017954-vobslprh	50	10	can	can	MD
cord-017954-vobslprh	50	11	be	be	VB
cord-017954-vobslprh	50	12	immunized	immunize	VBN
cord-017954-vobslprh	50	13	with	with	IN
cord-017954-vobslprh	50	14	a	a	DT
cord-017954-vobslprh	50	15	suspension	suspension	NN
cord-017954-vobslprh	50	16	of	of	IN
cord-017954-vobslprh	50	17	whole	whole	NN
cord-017954-vobslprh	50	18	Biozzi	Biozzi	NNP
cord-017954-vobslprh	50	19	ABH	ABH	NNP
cord-017954-vobslprh	50	20	spinal	spinal	JJ
cord-017954-vobslprh	50	21	cord	cord	NN
cord-017954-vobslprh	50	22	to	to	TO
cord-017954-vobslprh	50	23	develop	develop	VB
cord-017954-vobslprh	50	24	a	a	DT
cord-017954-vobslprh	50	25	very	very	RB
cord-017954-vobslprh	50	26	reproducible	reproducible	JJ
cord-017954-vobslprh	50	27	relapsing	relapse	VBG
cord-017954-vobslprh	50	28	-	-	HYPH
cord-017954-vobslprh	50	29	remitting	remit	VBG
cord-017954-vobslprh	50	30	disease	disease	NN
cord-017954-vobslprh	50	31	[	[	-LRB-
cord-017954-vobslprh	50	32	9	9	CD
cord-017954-vobslprh	50	33	]	]	-RRB-
cord-017954-vobslprh	50	34	.	.	.
cord-017954-vobslprh	51	1	The	the	DT
cord-017954-vobslprh	51	2	clinical	clinical	JJ
cord-017954-vobslprh	51	3	symptoms	symptom	NNS
cord-017954-vobslprh	51	4	of	of	IN
cord-017954-vobslprh	51	5	EAE	EAE	NNP
cord-017954-vobslprh	51	6	usually	usually	RB
cord-017954-vobslprh	51	7	develop	develop	VBP
cord-017954-vobslprh	51	8	at	at	IN
cord-017954-vobslprh	51	9	7	7	CD
cord-017954-vobslprh	51	10	-	-	SYM
cord-017954-vobslprh	51	11	15	15	CD
cord-017954-vobslprh	51	12	days	day	NNS
cord-017954-vobslprh	51	13	post	post	NN
cord-017954-vobslprh	51	14	-	-	NN
cord-017954-vobslprh	51	15	immunization	immunization	JJ
cord-017954-vobslprh	51	16	and	and	CC
cord-017954-vobslprh	51	17	include	include	VBP
cord-017954-vobslprh	51	18	weight	weight	NN
cord-017954-vobslprh	51	19	loss	loss	NN
cord-017954-vobslprh	51	20	,	,	,
cord-017954-vobslprh	51	21	loss	loss	NN
cord-017954-vobslprh	51	22	of	of	IN
cord-017954-vobslprh	51	23	tail	tail	NN
cord-017954-vobslprh	51	24	tone	tone	NN
cord-017954-vobslprh	51	25	and	and	CC
cord-017954-vobslprh	51	26	gait	gait	NN
cord-017954-vobslprh	51	27	,	,	,
cord-017954-vobslprh	51	28	and	and	CC
cord-017954-vobslprh	51	29	eventually	eventually	RB
cord-017954-vobslprh	51	30	paralysis	paralysis	NN
cord-017954-vobslprh	51	31	in	in	IN
cord-017954-vobslprh	51	32	either	either	DT
cord-017954-vobslprh	51	33	or	or	CC
cord-017954-vobslprh	51	34	both	both	DT
cord-017954-vobslprh	51	35	hind	hind	JJ
cord-017954-vobslprh	51	36	limbs	limb	NNS
cord-017954-vobslprh	51	37	.	.	.
cord-017954-vobslprh	52	1	Weight	weight	NN
cord-017954-vobslprh	52	2	loss	loss	NN
cord-017954-vobslprh	52	3	precedes	precede	VBZ
cord-017954-vobslprh	52	4	the	the	DT
cord-017954-vobslprh	52	5	onset	onset	NN
cord-017954-vobslprh	52	6	of	of	IN
cord-017954-vobslprh	52	7	disease	disease	NN
cord-017954-vobslprh	52	8	symptoms	symptom	NNS
cord-017954-vobslprh	52	9	and	and	CC
cord-017954-vobslprh	52	10	thus	thus	RB
cord-017954-vobslprh	52	11	can	can	MD
cord-017954-vobslprh	52	12	be	be	VB
cord-017954-vobslprh	52	13	used	use	VBN
cord-017954-vobslprh	52	14	as	as	IN
cord-017954-vobslprh	52	15	a	a	DT
cord-017954-vobslprh	52	16	marker	marker	NN
cord-017954-vobslprh	52	17	for	for	IN
cord-017954-vobslprh	52	18	disease	disease	NN
cord-017954-vobslprh	52	19	onset	onset	NN
cord-017954-vobslprh	52	20	.	.	.
cord-017954-vobslprh	53	1	Daily	daily	JJ
cord-017954-vobslprh	53	2	observation	observation	NN
cord-017954-vobslprh	53	3	of	of	IN
cord-017954-vobslprh	53	4	EAE	EAE	NNP
cord-017954-vobslprh	53	5	symptoms	symptom	NNS
cord-017954-vobslprh	53	6	and	and	CC
cord-017954-vobslprh	53	7	body	body	NN
cord-017954-vobslprh	53	8	weight	weight	NN
cord-017954-vobslprh	53	9	is	be	VBZ
cord-017954-vobslprh	53	10	noninvasive	noninvasive	JJ
cord-017954-vobslprh	53	11	and	and	CC
cord-017954-vobslprh	53	12	is	be	VBZ
cord-017954-vobslprh	53	13	therefore	therefore	RB
cord-017954-vobslprh	53	14	a	a	DT
cord-017954-vobslprh	53	15	great	great	JJ
cord-017954-vobslprh	53	16	advantage	advantage	NN
cord-017954-vobslprh	53	17	to	to	IN
cord-017954-vobslprh	53	18	researchers	researcher	NNS
cord-017954-vobslprh	53	19	,	,	,
cord-017954-vobslprh	53	20	allowing	allow	VBG
cord-017954-vobslprh	53	21	the	the	DT
cord-017954-vobslprh	53	22	disease	disease	NN
cord-017954-vobslprh	53	23	process	process	NN
cord-017954-vobslprh	53	24	to	to	TO
cord-017954-vobslprh	53	25	be	be	VB
cord-017954-vobslprh	53	26	followed	follow	VBN
cord-017954-vobslprh	53	27	,	,	,
cord-017954-vobslprh	53	28	especially	especially	RB
cord-017954-vobslprh	53	29	when	when	WRB
cord-017954-vobslprh	53	30	studying	study	VBG
cord-017954-vobslprh	53	31	the	the	DT
cord-017954-vobslprh	53	32	effects	effect	NNS
cord-017954-vobslprh	53	33	of	of	IN
cord-017954-vobslprh	53	34	drug	drug	NN
cord-017954-vobslprh	53	35	treatments	treatment	NNS
cord-017954-vobslprh	53	36	.	.	.
cord-017954-vobslprh	54	1	Of	of	IN
cord-017954-vobslprh	54	2	note	note	VB
cord-017954-vobslprh	54	3	,	,	,
cord-017954-vobslprh	54	4	some	some	DT
cord-017954-vobslprh	54	5	mouse	mouse	NN
cord-017954-vobslprh	54	6	strains	strain	NNS
cord-017954-vobslprh	54	7	are	be	VBP
cord-017954-vobslprh	54	8	resistant	resistant	JJ
cord-017954-vobslprh	54	9	to	to	IN
cord-017954-vobslprh	54	10	EAE	EAE	NNP
cord-017954-vobslprh	54	11	(	(	-LRB-
cord-017954-vobslprh	54	12	A	A	NNP
cord-017954-vobslprh	54	13	/	/	SYM
cord-017954-vobslprh	54	14	J	J	NNP
cord-017954-vobslprh	54	15	,	,	,
cord-017954-vobslprh	54	16	C3H	C3H	NNP
cord-017954-vobslprh	54	17	/	/	SYM
cord-017954-vobslprh	54	18	HeJ	hej	NN
cord-017954-vobslprh	54	19	,	,	,
cord-017954-vobslprh	54	20	AKR	AKR	NNP
cord-017954-vobslprh	54	21	,	,	,
cord-017954-vobslprh	54	22	NZW	NZW	NNP
cord-017954-vobslprh	54	23	,	,	,
cord-017954-vobslprh	54	24	and	and	CC
cord-017954-vobslprh	54	25	DBA/2	DBA/2	NNP
cord-017954-vobslprh	54	26	)	)	-RRB-
cord-017954-vobslprh	54	27	.	.	.
cord-017954-vobslprh	55	1	In	in	IN
cord-017954-vobslprh	55	2	addition	addition	NN
cord-017954-vobslprh	55	3	to	to	IN
cord-017954-vobslprh	55	4	the	the	DT
cord-017954-vobslprh	55	5	importance	importance	NN
cord-017954-vobslprh	55	6	of	of	IN
cord-017954-vobslprh	55	7	environmental	environmental	JJ
cord-017954-vobslprh	55	8	factors	factor	NNS
cord-017954-vobslprh	55	9	,	,	,
cord-017954-vobslprh	55	10	it	-PRON-	PRP
cord-017954-vobslprh	55	11	is	be	VBZ
cord-017954-vobslprh	55	12	thought	think	VBN
cord-017954-vobslprh	55	13	that	that	IN
cord-017954-vobslprh	55	14	multiple	multiple	JJ
cord-017954-vobslprh	55	15	predisposing	predisposing	JJ
cord-017954-vobslprh	55	16	genetic	genetic	JJ
cord-017954-vobslprh	55	17	elements	element	NNS
cord-017954-vobslprh	55	18	might	may	MD
cord-017954-vobslprh	55	19	be	be	VB
cord-017954-vobslprh	55	20	involved	involve	VBN
cord-017954-vobslprh	55	21	in	in	IN
cord-017954-vobslprh	55	22	susceptibility	susceptibility	NN
cord-017954-vobslprh	55	23	to	to	IN
cord-017954-vobslprh	55	24	MS	MS	NNP
cord-017954-vobslprh	55	25	(	(	-LRB-
cord-017954-vobslprh	55	26	reviewed	review	VBN
cord-017954-vobslprh	55	27	by	by	IN
cord-017954-vobslprh	55	28	Ebers	Ebers	NNP
cord-017954-vobslprh	55	29	1994	1994	CD
cord-017954-vobslprh	55	30	)	)	-RRB-
cord-017954-vobslprh	55	31	[	[	-LRB-
cord-017954-vobslprh	55	32	10	10	CD
cord-017954-vobslprh	55	33	]	]	-RRB-
cord-017954-vobslprh	55	34	.	.	.
cord-017954-vobslprh	56	1	Therefore	therefore	RB
cord-017954-vobslprh	56	2	,	,	,
cord-017954-vobslprh	56	3	the	the	DT
cord-017954-vobslprh	56	4	backcrossing	backcrossing	NN
cord-017954-vobslprh	56	5	of	of	IN
cord-017954-vobslprh	56	6	EAE	EAE	NNP
cord-017954-vobslprh	56	7	-	-	HYPH
cord-017954-vobslprh	56	8	resistant	resistant	JJ
cord-017954-vobslprh	56	9	mice	mouse	NNS
cord-017954-vobslprh	56	10	with	with	IN
cord-017954-vobslprh	56	11	EAE	EAE	NNP
cord-017954-vobslprh	56	12	-	-	HYPH
cord-017954-vobslprh	56	13	susceptible	susceptible	JJ
cord-017954-vobslprh	56	14	strains	strain	NNS
cord-017954-vobslprh	56	15	has	have	VBZ
cord-017954-vobslprh	56	16	been	be	VBN
cord-017954-vobslprh	56	17	useful	useful	JJ
cord-017954-vobslprh	56	18	for	for	IN
cord-017954-vobslprh	56	19	genetic	genetic	JJ
cord-017954-vobslprh	56	20	susceptibility	susceptibility	NN
cord-017954-vobslprh	56	21	studies	study	NNS
cord-017954-vobslprh	56	22	.	.	.
cord-017954-vobslprh	57	1	The	the	DT
cord-017954-vobslprh	57	2	second	second	JJ
cord-017954-vobslprh	57	3	model	model	NN
cord-017954-vobslprh	57	4	of	of	IN
cord-017954-vobslprh	57	5	EAE	EAE	NNP
cord-017954-vobslprh	57	6	is	be	VBZ
cord-017954-vobslprh	57	7	passive	passive	JJ
cord-017954-vobslprh	57	8	and	and	CC
cord-017954-vobslprh	57	9	involves	involve	VBZ
cord-017954-vobslprh	57	10	the	the	DT
cord-017954-vobslprh	57	11	in	in	FW
cord-017954-vobslprh	57	12	vitro	vitro	FW
cord-017954-vobslprh	57	13	restimulation	restimulation	NN
cord-017954-vobslprh	57	14	of	of	IN
cord-017954-vobslprh	57	15	encephalitogenic	encephalitogenic	NNP
cord-017954-vobslprh	57	16	T	T	NNP
cord-017954-vobslprh	57	17	cells	cell	NNS
cord-017954-vobslprh	57	18	with	with	IN
cord-017954-vobslprh	57	19	the	the	DT
cord-017954-vobslprh	57	20	myelin	myelin	JJ
cord-017954-vobslprh	57	21	peptide	peptide	NN
cord-017954-vobslprh	57	22	used	use	VBD
cord-017954-vobslprh	57	23	to	to	TO
cord-017954-vobslprh	57	24	immunize	immunize	VB
cord-017954-vobslprh	57	25	the	the	DT
cord-017954-vobslprh	57	26	original	original	JJ
cord-017954-vobslprh	57	27	T	t	NN
cord-017954-vobslprh	57	28	-	-	HYPH
cord-017954-vobslprh	57	29	cell	cell	NN
cord-017954-vobslprh	57	30	donor	donor	NN
cord-017954-vobslprh	57	31	animals	animal	NNS
cord-017954-vobslprh	57	32	[	[	-LRB-
cord-017954-vobslprh	57	33	11	11	CD
cord-017954-vobslprh	57	34	]	]	-RRB-
cord-017954-vobslprh	57	35	.	.	.
cord-017954-vobslprh	58	1	The	the	DT
cord-017954-vobslprh	58	2	successful	successful	JJ
cord-017954-vobslprh	58	3	culture	culture	NN
cord-017954-vobslprh	58	4	of	of	IN
cord-017954-vobslprh	58	5	these	these	DT
cord-017954-vobslprh	58	6	cells	cell	NNS
cord-017954-vobslprh	58	7	usually	usually	RB
cord-017954-vobslprh	58	8	requires	require	VBZ
cord-017954-vobslprh	58	9	the	the	DT
cord-017954-vobslprh	58	10	addition	addition	NN
cord-017954-vobslprh	58	11	of	of	IN
cord-017954-vobslprh	58	12	Th1	th1	NN
cord-017954-vobslprh	58	13	cytokines	cytokine	NNS
cord-017954-vobslprh	58	14	such	such	JJ
cord-017954-vobslprh	58	15	as	as	IN
cord-017954-vobslprh	58	16	IL-12	IL-12	NNP
cord-017954-vobslprh	58	17	[	[	-LRB-
cord-017954-vobslprh	58	18	12	12	CD
cord-017954-vobslprh	58	19	]	]	-RRB-
cord-017954-vobslprh	58	20	.	.	.
cord-017954-vobslprh	59	1	Once	once	IN
cord-017954-vobslprh	59	2	cells	cell	NNS
cord-017954-vobslprh	59	3	have	have	VBP
cord-017954-vobslprh	59	4	been	be	VBN
cord-017954-vobslprh	59	5	sufficiently	sufficiently	RB
cord-017954-vobslprh	59	6	activated	activate	VBN
cord-017954-vobslprh	59	7	,	,	,
cord-017954-vobslprh	59	8	they	-PRON-	PRP
cord-017954-vobslprh	59	9	are	be	VBP
cord-017954-vobslprh	59	10	intravenously	intravenously	RB
cord-017954-vobslprh	59	11	administered	administer	VBN
cord-017954-vobslprh	59	12	to	to	IN
cord-017954-vobslprh	59	13	naïve	naïve	JJ
cord-017954-vobslprh	59	14	animals	animal	NNS
cord-017954-vobslprh	59	15	,	,	,
cord-017954-vobslprh	59	16	where	where	WRB
cord-017954-vobslprh	59	17	they	-PRON-	PRP
cord-017954-vobslprh	59	18	traffic	traffic	VBP
cord-017954-vobslprh	59	19	to	to	IN
cord-017954-vobslprh	59	20	the	the	DT
cord-017954-vobslprh	59	21	CNS	CNS	NNP
cord-017954-vobslprh	59	22	and	and	CC
cord-017954-vobslprh	59	23	induce	induce	VB
cord-017954-vobslprh	59	24	disease	disease	NN
cord-017954-vobslprh	59	25	.	.	.
cord-017954-vobslprh	60	1	The	the	DT
cord-017954-vobslprh	60	2	CNS	CNS	NNP
cord-017954-vobslprh	60	3	pathology	pathology	NN
cord-017954-vobslprh	60	4	and	and	CC
cord-017954-vobslprh	60	5	disease	disease	NN
cord-017954-vobslprh	60	6	course	course	NN
cord-017954-vobslprh	60	7	are	be	VBP
cord-017954-vobslprh	60	8	similar	similar	JJ
cord-017954-vobslprh	60	9	to	to	IN
cord-017954-vobslprh	60	10	that	that	DT
cord-017954-vobslprh	60	11	for	for	IN
cord-017954-vobslprh	60	12	active	active	JJ
cord-017954-vobslprh	60	13	EAE	EAE	NNP
cord-017954-vobslprh	60	14	.	.	.
cord-017954-vobslprh	61	1	The	the	DT
cord-017954-vobslprh	61	2	ability	ability	NN
cord-017954-vobslprh	61	3	of	of	IN
cord-017954-vobslprh	61	4	MBP	MBP	NNP
cord-017954-vobslprh	61	5	-	-	HYPH
cord-017954-vobslprh	61	6	specific	specific	JJ
cord-017954-vobslprh	61	7	T	t	NN
cord-017954-vobslprh	61	8	cells	cell	NNS
cord-017954-vobslprh	61	9	to	to	TO
cord-017954-vobslprh	61	10	induce	induce	VB
cord-017954-vobslprh	61	11	EAE	EAE	NNP
cord-017954-vobslprh	61	12	in	in	IN
cord-017954-vobslprh	61	13	rats	rat	NNS
cord-017954-vobslprh	61	14	and	and	CC
cord-017954-vobslprh	61	15	mice	mouse	NNS
cord-017954-vobslprh	61	16	was	be	VBD
cord-017954-vobslprh	61	17	some	some	DT
cord-017954-vobslprh	61	18	of	of	IN
cord-017954-vobslprh	61	19	the	the	DT
cord-017954-vobslprh	61	20	earliest	early	JJS
cord-017954-vobslprh	61	21	evidence	evidence	NN
cord-017954-vobslprh	61	22	to	to	TO
cord-017954-vobslprh	61	23	suggest	suggest	VB
cord-017954-vobslprh	61	24	that	that	IN
cord-017954-vobslprh	61	25	MS	MS	NNP
cord-017954-vobslprh	61	26	has	have	VBZ
cord-017954-vobslprh	61	27	an	an	DT
cord-017954-vobslprh	61	28	autoimmune	autoimmune	JJ
cord-017954-vobslprh	61	29	aetiology	aetiology	NN
cord-017954-vobslprh	61	30	[	[	-LRB-
cord-017954-vobslprh	61	31	3	3	CD
cord-017954-vobslprh	61	32	,	,	,
cord-017954-vobslprh	61	33	4	4	CD
cord-017954-vobslprh	61	34	]	]	-RRB-
cord-017954-vobslprh	61	35	.	.	.
cord-017954-vobslprh	62	1	Another	another	DT
cord-017954-vobslprh	62	2	evidence	evidence	NN
cord-017954-vobslprh	62	3	for	for	IN
cord-017954-vobslprh	62	4	an	an	DT
cord-017954-vobslprh	62	5	autoimmune	autoimmune	JJ
cord-017954-vobslprh	62	6	inflammatory	inflammatory	JJ
cord-017954-vobslprh	62	7	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	62	8	includes	include	VBZ
cord-017954-vobslprh	62	9	the	the	DT
cord-017954-vobslprh	62	10	presence	presence	NN
cord-017954-vobslprh	62	11	of	of	IN
cord-017954-vobslprh	62	12	MHC	MHC	NNP
cord-017954-vobslprh	62	13	class	class	NN
cord-017954-vobslprh	62	14	II	II	NNP
cord-017954-vobslprh	62	15	-	-	HYPH
cord-017954-vobslprh	62	16	restricted	restrict	VBN
cord-017954-vobslprh	62	17	CD4þ	CD4þ	NNP
cord-017954-vobslprh	62	18	T	T	NNP
cord-017954-vobslprh	62	19	cells	cell	NNS
cord-017954-vobslprh	62	20	that	that	WDT
cord-017954-vobslprh	62	21	recognize	recognize	VBP
cord-017954-vobslprh	62	22	myelin	myelin	NN
cord-017954-vobslprh	62	23	antigens	antigen	NNS
cord-017954-vobslprh	62	24	such	such	JJ
cord-017954-vobslprh	62	25	as	as	IN
cord-017954-vobslprh	62	26	myelin	myelin	JJ
cord-017954-vobslprh	62	27	basic	basic	JJ
cord-017954-vobslprh	62	28	protein	protein	NN
cord-017954-vobslprh	62	29	(	(	-LRB-
cord-017954-vobslprh	62	30	MBP	MBP	NNP
cord-017954-vobslprh	62	31	)	)	-RRB-
cord-017954-vobslprh	62	32	,	,	,
cord-017954-vobslprh	62	33	PLP	PLP	NNP
cord-017954-vobslprh	62	34	,	,	,
cord-017954-vobslprh	62	35	and	and	CC
cord-017954-vobslprh	62	36	MOG	MOG	NNP
cord-017954-vobslprh	62	37	in	in	IN
cord-017954-vobslprh	62	38	MS	MS	NNP
cord-017954-vobslprh	62	39	patients	patient	NNS
cord-017954-vobslprh	62	40	as	as	RB
cord-017954-vobslprh	62	41	well	well	RB
cord-017954-vobslprh	62	42	as	as	IN
cord-017954-vobslprh	62	43	healthy	healthy	JJ
cord-017954-vobslprh	62	44	individuals	individual	NNS
cord-017954-vobslprh	62	45	and	and	CC
cord-017954-vobslprh	62	46	that	that	IN
cord-017954-vobslprh	62	47	MHC	MHC	NNP
cord-017954-vobslprh	62	48	class	class	NN
cord-017954-vobslprh	62	49	II	II	NNP
cord-017954-vobslprh	62	50	genes	gene	NNS
cord-017954-vobslprh	62	51	are	be	VBP
cord-017954-vobslprh	62	52	associated	associate	VBN
cord-017954-vobslprh	62	53	with	with	IN
cord-017954-vobslprh	62	54	MS	MS	NNP
cord-017954-vobslprh	62	55	susceptibility	susceptibility	NN
cord-017954-vobslprh	62	56	[	[	-LRB-
cord-017954-vobslprh	62	57	13	13	CD
cord-017954-vobslprh	62	58	]	]	-RRB-
cord-017954-vobslprh	62	59	[	[	-LRB-
cord-017954-vobslprh	62	60	14	14	CD
cord-017954-vobslprh	62	61	]	]	-RRB-
cord-017954-vobslprh	62	62	[	[	-LRB-
cord-017954-vobslprh	62	63	15	15	CD
cord-017954-vobslprh	62	64	]	]	-RRB-
cord-017954-vobslprh	62	65	.	.	.
cord-017954-vobslprh	63	1	Because	because	IN
cord-017954-vobslprh	63	2	T	t	NN
cord-017954-vobslprh	63	3	cells	cell	NNS
cord-017954-vobslprh	63	4	are	be	VBP
cord-017954-vobslprh	63	5	already	already	RB
cord-017954-vobslprh	63	6	activated	activate	VBN
cord-017954-vobslprh	63	7	when	when	WRB
cord-017954-vobslprh	63	8	administered	administer	VBN
cord-017954-vobslprh	63	9	into	into	IN
cord-017954-vobslprh	63	10	naïve	naïve	JJ
cord-017954-vobslprh	63	11	animals	animal	NNS
cord-017954-vobslprh	63	12	,	,	,
cord-017954-vobslprh	63	13	passive	passive	JJ
cord-017954-vobslprh	63	14	EAE	EAE	NNP
cord-017954-vobslprh	63	15	is	be	VBZ
cord-017954-vobslprh	63	16	a	a	DT
cord-017954-vobslprh	63	17	suitable	suitable	JJ
cord-017954-vobslprh	63	18	model	model	NN
cord-017954-vobslprh	63	19	for	for	IN
cord-017954-vobslprh	63	20	investigating	investigate	VBG
cord-017954-vobslprh	63	21	the	the	DT
cord-017954-vobslprh	63	22	effector	effector	JJ
cord-017954-vobslprh	63	23	phase	phase	NN
cord-017954-vobslprh	63	24	of	of	IN
cord-017954-vobslprh	63	25	disease	disease	NN
cord-017954-vobslprh	63	26	.	.	.
cord-017954-vobslprh	64	1	It	-PRON-	PRP
cord-017954-vobslprh	64	2	has	have	VBZ
cord-017954-vobslprh	64	3	some	some	DT
cord-017954-vobslprh	64	4	advantages	advantage	NNS
cord-017954-vobslprh	64	5	over	over	IN
cord-017954-vobslprh	64	6	passive	passive	JJ
cord-017954-vobslprh	64	7	EAE	EAE	NNP
cord-017954-vobslprh	64	8	as	as	IN
cord-017954-vobslprh	64	9	an	an	DT
cord-017954-vobslprh	64	10	immunization	immunization	NN
cord-017954-vobslprh	64	11	step	step	NN
cord-017954-vobslprh	64	12	is	be	VBZ
cord-017954-vobslprh	64	13	not	not	RB
cord-017954-vobslprh	64	14	required	require	VBN
cord-017954-vobslprh	64	15	;	;	:
cord-017954-vobslprh	64	16	thus	thus	RB
cord-017954-vobslprh	64	17	,	,	,
cord-017954-vobslprh	64	18	there	there	EX
cord-017954-vobslprh	64	19	is	be	VBZ
cord-017954-vobslprh	64	20	no	no	DT
cord-017954-vobslprh	64	21	antigen	antigen	NN
cord-017954-vobslprh	64	22	reserve	reserve	NN
cord-017954-vobslprh	64	23	that	that	WDT
cord-017954-vobslprh	64	24	continually	continually	RB
cord-017954-vobslprh	64	25	activates	activate	VBZ
cord-017954-vobslprh	64	26	naïve	naïve	JJ
cord-017954-vobslprh	64	27	T	t	NN
cord-017954-vobslprh	64	28	cells	cell	NNS
cord-017954-vobslprh	64	29	,	,	,
cord-017954-vobslprh	64	30	which	which	WDT
cord-017954-vobslprh	64	31	likely	likely	RB
cord-017954-vobslprh	64	32	boosts	boost	VBZ
cord-017954-vobslprh	64	33	the	the	DT
cord-017954-vobslprh	64	34	immune	immune	JJ
cord-017954-vobslprh	64	35	system	system	NN
cord-017954-vobslprh	64	36	nonspecifically	nonspecifically	RB
cord-017954-vobslprh	64	37	.	.	.
cord-017954-vobslprh	65	1	Furthermore	furthermore	RB
cord-017954-vobslprh	65	2	,	,	,
cord-017954-vobslprh	65	3	the	the	DT
cord-017954-vobslprh	65	4	direct	direct	JJ
cord-017954-vobslprh	65	5	injection	injection	NN
cord-017954-vobslprh	65	6	of	of	IN
cord-017954-vobslprh	65	7	effector	effector	NN
cord-017954-vobslprh	65	8	T	t	NN
cord-017954-vobslprh	65	9	cells	cell	NNS
cord-017954-vobslprh	65	10	into	into	IN
cord-017954-vobslprh	65	11	naïve	naïve	JJ
cord-017954-vobslprh	65	12	mice	mouse	NNS
cord-017954-vobslprh	65	13	allows	allow	VBZ
cord-017954-vobslprh	65	14	the	the	DT
cord-017954-vobslprh	65	15	definitive	definitive	JJ
cord-017954-vobslprh	65	16	starting	starting	NN
cord-017954-vobslprh	65	17	point	point	NN
cord-017954-vobslprh	65	18	of	of	IN
cord-017954-vobslprh	65	19	disease	disease	NN
cord-017954-vobslprh	65	20	induction	induction	NN
cord-017954-vobslprh	65	21	to	to	TO
cord-017954-vobslprh	65	22	be	be	VB
cord-017954-vobslprh	65	23	known	know	VBN
cord-017954-vobslprh	65	24	,	,	,
cord-017954-vobslprh	65	25	which	which	WDT
cord-017954-vobslprh	65	26	might	may	MD
cord-017954-vobslprh	65	27	be	be	VB
cord-017954-vobslprh	65	28	useful	useful	JJ
cord-017954-vobslprh	65	29	for	for	IN
cord-017954-vobslprh	65	30	treatment	treatment	NN
cord-017954-vobslprh	65	31	studies	study	NNS
cord-017954-vobslprh	65	32	,	,	,
cord-017954-vobslprh	65	33	and	and	CC
cord-017954-vobslprh	65	34	finally	finally	RB
cord-017954-vobslprh	65	35	encephalitogenic	encephalitogenic	NNP
cord-017954-vobslprh	65	36	T	T	NNP
cord-017954-vobslprh	65	37	cells	cell	NNS
cord-017954-vobslprh	65	38	can	can	MD
cord-017954-vobslprh	65	39	be	be	VB
cord-017954-vobslprh	65	40	directly	directly	RB
cord-017954-vobslprh	65	41	tracked	track	VBN
cord-017954-vobslprh	65	42	in	in	IN
cord-017954-vobslprh	65	43	vivo	vivo	NN
cord-017954-vobslprh	65	44	to	to	TO
cord-017954-vobslprh	65	45	study	study	VB
cord-017954-vobslprh	65	46	methods	method	NNS
cord-017954-vobslprh	65	47	of	of	IN
cord-017954-vobslprh	65	48	extravasation	extravasation	NN
cord-017954-vobslprh	65	49	into	into	IN
cord-017954-vobslprh	65	50	the	the	DT
cord-017954-vobslprh	65	51	CNS	CNS	NNP
cord-017954-vobslprh	65	52	and	and	CC
cord-017954-vobslprh	65	53	for	for	IN
cord-017954-vobslprh	65	54	isolation	isolation	NN
cord-017954-vobslprh	65	55	of	of	IN
cord-017954-vobslprh	65	56	antigen	antigen	NN
cord-017954-vobslprh	65	57	-	-	HYPH
cord-017954-vobslprh	65	58	specific	specific	JJ
cord-017954-vobslprh	65	59	T	t	NN
cord-017954-vobslprh	65	60	cells	cell	NNS
cord-017954-vobslprh	65	61	.	.	.
cord-017954-vobslprh	66	1	Early	early	JJ
cord-017954-vobslprh	66	2	studies	study	NNS
cord-017954-vobslprh	66	3	demonstrated	demonstrate	VBD
cord-017954-vobslprh	66	4	that	that	IN
cord-017954-vobslprh	66	5	activated	activate	VBN
cord-017954-vobslprh	66	6	myelin	myelin	NN
cord-017954-vobslprh	66	7	-	-	HYPH
cord-017954-vobslprh	66	8	specific	specific	JJ
cord-017954-vobslprh	66	9	Th1	th1	NN
cord-017954-vobslprh	66	10	CD4þ	CD4þ	NNP
cord-017954-vobslprh	66	11	T	T	NNP
cord-017954-vobslprh	66	12	cells	cell	NNS
cord-017954-vobslprh	66	13	secreting	secrete	VBG
cord-017954-vobslprh	66	14	IFN	IFN	NNP
cord-017954-vobslprh	66	15	-	-	HYPH
cord-017954-vobslprh	66	16	γ	γ	NNP
cord-017954-vobslprh	66	17	,	,	,
cord-017954-vobslprh	66	18	TNF	TNF	NNP
cord-017954-vobslprh	66	19	-	-	HYPH
cord-017954-vobslprh	66	20	α	α	NNP
cord-017954-vobslprh	66	21	,	,	,
cord-017954-vobslprh	66	22	and	and	CC
cord-017954-vobslprh	66	23	IL-2	IL-2	NNP
cord-017954-vobslprh	66	24	were	be	VBD
cord-017954-vobslprh	66	25	encephalitogenic	encephalitogenic	NNP
cord-017954-vobslprh	66	26	and	and	CC
cord-017954-vobslprh	66	27	sufficient	sufficient	JJ
cord-017954-vobslprh	66	28	to	to	TO
cord-017954-vobslprh	66	29	induce	induce	VB
cord-017954-vobslprh	66	30	EAE	EAE	NNP
cord-017954-vobslprh	66	31	when	when	WRB
cord-017954-vobslprh	66	32	transferred	transfer	VBN
cord-017954-vobslprh	66	33	into	into	IN
cord-017954-vobslprh	66	34	naïve	naïve	JJ
cord-017954-vobslprh	66	35	mice	mouse	NNS
cord-017954-vobslprh	66	36	of	of	IN
cord-017954-vobslprh	66	37	a	a	DT
cord-017954-vobslprh	66	38	susceptible	susceptible	JJ
cord-017954-vobslprh	66	39	genetic	genetic	JJ
cord-017954-vobslprh	66	40	background	background	NN
cord-017954-vobslprh	66	41	[	[	-LRB-
cord-017954-vobslprh	66	42	16	16	CD
cord-017954-vobslprh	66	43	]	]	-RRB-
cord-017954-vobslprh	66	44	[	[	-LRB-
cord-017954-vobslprh	66	45	17	17	CD
cord-017954-vobslprh	66	46	]	]	-RRB-
cord-017954-vobslprh	66	47	[	[	-LRB-
cord-017954-vobslprh	66	48	18	18	CD
cord-017954-vobslprh	66	49	]	]	-RRB-
cord-017954-vobslprh	66	50	.	.	.
cord-017954-vobslprh	67	1	However	however	RB
cord-017954-vobslprh	67	2	,	,	,
cord-017954-vobslprh	67	3	the	the	DT
cord-017954-vobslprh	67	4	knockout	knockout	NN
cord-017954-vobslprh	67	5	of	of	IN
cord-017954-vobslprh	67	6	genes	gene	NNS
cord-017954-vobslprh	67	7	encoding	encode	VBG
cord-017954-vobslprh	67	8	IFN	IFN	NNP
cord-017954-vobslprh	67	9	-	-	HYPH
cord-017954-vobslprh	67	10	γ	γ	NNP
cord-017954-vobslprh	67	11	or	or	CC
cord-017954-vobslprh	67	12	TNF	TNF	NNP
cord-017954-vobslprh	67	13	-	-	HYPH
cord-017954-vobslprh	67	14	α	α	NNP
cord-017954-vobslprh	67	15	[	[	-LRB-
cord-017954-vobslprh	67	16	19	19	CD
cord-017954-vobslprh	67	17	,	,	,
cord-017954-vobslprh	67	18	20	20	CD
cord-017954-vobslprh	67	19	]	]	-RRB-
cord-017954-vobslprh	67	20	exacerbated	exacerbate	VBN
cord-017954-vobslprh	67	21	EAE	EAE	NNP
cord-017954-vobslprh	67	22	and	and	CC
cord-017954-vobslprh	67	23	therefore	therefore	RB
cord-017954-vobslprh	67	24	the	the	DT
cord-017954-vobslprh	67	25	role	role	NN
cord-017954-vobslprh	67	26	of	of	IN
cord-017954-vobslprh	67	27	Th1-induced	Th1-induced	NNP
cord-017954-vobslprh	67	28	EAE	EAE	NNP
cord-017954-vobslprh	67	29	was	be	VBD
cord-017954-vobslprh	67	30	not	not	RB
cord-017954-vobslprh	67	31	straightforward	straightforward	JJ
cord-017954-vobslprh	67	32	.	.	.
cord-017954-vobslprh	68	1	IL-17	IL-17	NNP
cord-017954-vobslprh	69	1	production	production	NN
cord-017954-vobslprh	69	2	by	by	IN
cord-017954-vobslprh	69	3	CNS	CNS	NNP
cord-017954-vobslprh	69	4	-	-	HYPH
cord-017954-vobslprh	69	5	infiltrating	infiltrate	VBG
cord-017954-vobslprh	69	6	T	t	NN
cord-017954-vobslprh	69	7	cells	cell	NNS
cord-017954-vobslprh	69	8	is	be	VBZ
cord-017954-vobslprh	69	9	important	important	JJ
cord-017954-vobslprh	69	10	for	for	IN
cord-017954-vobslprh	69	11	blood	blood	NN
cord-017954-vobslprh	69	12	-	-	HYPH
cord-017954-vobslprh	69	13	brain	brain	NN
cord-017954-vobslprh	69	14	barrier	barrier	NN
cord-017954-vobslprh	69	15	dysfunction	dysfunction	NN
cord-017954-vobslprh	69	16	and	and	CC
cord-017954-vobslprh	69	17	lesion	lesion	NN
cord-017954-vobslprh	69	18	formation	formation	NN
cord-017954-vobslprh	69	19	in	in	IN
cord-017954-vobslprh	69	20	MS	MS	NNP
cord-017954-vobslprh	69	21	patients	patient	NNS
cord-017954-vobslprh	69	22	[	[	-LRB-
cord-017954-vobslprh	69	23	21	21	CD
cord-017954-vobslprh	69	24	,	,	,
cord-017954-vobslprh	69	25	22	22	CD
cord-017954-vobslprh	69	26	]	]	-RRB-
cord-017954-vobslprh	69	27	,	,	,
cord-017954-vobslprh	69	28	and	and	CC
cord-017954-vobslprh	69	29	the	the	DT
cord-017954-vobslprh	69	30	genetic	genetic	JJ
cord-017954-vobslprh	69	31	inhibition	inhibition	NN
cord-017954-vobslprh	69	32	of	of	IN
cord-017954-vobslprh	69	33	IL-17A	IL-17A	NNP
cord-017954-vobslprh	69	34	in	in	IN
cord-017954-vobslprh	69	35	mice	mouse	NNS
cord-017954-vobslprh	69	36	was	be	VBD
cord-017954-vobslprh	69	37	sufficient	sufficient	JJ
cord-017954-vobslprh	69	38	to	to	TO
cord-017954-vobslprh	69	39	partly	partly	RB
cord-017954-vobslprh	69	40	ameliorate	ameliorate	VB
cord-017954-vobslprh	69	41	EAE	EAE	NNP
cord-017954-vobslprh	69	42	in	in	IN
cord-017954-vobslprh	69	43	mice	mouse	NNS
cord-017954-vobslprh	69	44	[	[	-LRB-
cord-017954-vobslprh	69	45	23	23	CD
cord-017954-vobslprh	69	46	]	]	-RRB-
cord-017954-vobslprh	69	47	.	.	.
cord-017954-vobslprh	70	1	This	this	DT
cord-017954-vobslprh	70	2	indicated	indicate	VBD
cord-017954-vobslprh	70	3	that	that	IN
cord-017954-vobslprh	70	4	Th17	th17	CD
cord-017954-vobslprh	70	5	cells	cell	NNS
cord-017954-vobslprh	70	6	,	,	,
cord-017954-vobslprh	70	7	an	an	DT
cord-017954-vobslprh	70	8	alternative	alternative	JJ
cord-017954-vobslprh	70	9	effector	effector	NN
cord-017954-vobslprh	70	10	T	t	NN
cord-017954-vobslprh	70	11	-	-	HYPH
cord-017954-vobslprh	70	12	cell	cell	NN
cord-017954-vobslprh	70	13	subset	subset	JJ
cord-017954-vobslprh	70	14	to	to	IN
cord-017954-vobslprh	70	15	Th1	th1	NN
cord-017954-vobslprh	70	16	,	,	,
cord-017954-vobslprh	70	17	might	may	MD
cord-017954-vobslprh	70	18	be	be	VB
cord-017954-vobslprh	70	19	the	the	DT
cord-017954-vobslprh	70	20	critical	critical	JJ
cord-017954-vobslprh	70	21	effector	effector	NN
cord-017954-vobslprh	70	22	cells	cell	NNS
cord-017954-vobslprh	70	23	in	in	IN
cord-017954-vobslprh	70	24	EAE	EAE	NNP
cord-017954-vobslprh	70	25	.	.	.
cord-017954-vobslprh	71	1	Indeed	indeed	RB
cord-017954-vobslprh	71	2	,	,	,
cord-017954-vobslprh	71	3	Th17	Th17	NNP
cord-017954-vobslprh	71	4	cells	cell	NNS
cord-017954-vobslprh	71	5	cultured	culture	VBN
cord-017954-vobslprh	71	6	in	in	IN
cord-017954-vobslprh	71	7	the	the	DT
cord-017954-vobslprh	71	8	presence	presence	NN
cord-017954-vobslprh	71	9	of	of	IN
cord-017954-vobslprh	71	10	IL-23	IL-23	NNP
cord-017954-vobslprh	71	11	and	and	CC
cord-017954-vobslprh	71	12	other	other	JJ
cord-017954-vobslprh	71	13	cytokines	cytokine	NNS
cord-017954-vobslprh	71	14	become	become	VBP
cord-017954-vobslprh	71	15	highly	highly	RB
cord-017954-vobslprh	71	16	pathogenic	pathogenic	JJ
cord-017954-vobslprh	71	17	and	and	CC
cord-017954-vobslprh	71	18	can	can	MD
cord-017954-vobslprh	71	19	induce	induce	VB
cord-017954-vobslprh	71	20	EAE	EAE	NNP
cord-017954-vobslprh	71	21	when	when	WRB
cord-017954-vobslprh	71	22	transferred	transfer	VBN
cord-017954-vobslprh	71	23	into	into	IN
cord-017954-vobslprh	71	24	naïve	naïve	JJ
cord-017954-vobslprh	71	25	mice	mouse	NNS
cord-017954-vobslprh	71	26	[	[	-LRB-
cord-017954-vobslprh	71	27	24	24	CD
cord-017954-vobslprh	71	28	]	]	-RRB-
cord-017954-vobslprh	71	29	.	.	.
cord-017954-vobslprh	72	1	Th17	Th17	NNP
cord-017954-vobslprh	73	1	cells	cell	NNS
cord-017954-vobslprh	73	2	show	show	VBP
cord-017954-vobslprh	73	3	an	an	DT
cord-017954-vobslprh	73	4	enhanced	enhanced	JJ
cord-017954-vobslprh	73	5	efficiency	efficiency	NN
cord-017954-vobslprh	73	6	at	at	IN
cord-017954-vobslprh	73	7	inducing	induce	VBG
cord-017954-vobslprh	73	8	EAE	EAE	NNP
cord-017954-vobslprh	73	9	compared	compare	VBN
cord-017954-vobslprh	73	10	with	with	IN
cord-017954-vobslprh	73	11	Th1	th1	NN
cord-017954-vobslprh	73	12	cells	cell	NNS
cord-017954-vobslprh	73	13	[	[	-LRB-
cord-017954-vobslprh	73	14	24	24	CD
cord-017954-vobslprh	73	15	]	]	-RRB-
cord-017954-vobslprh	73	16	and	and	CC
cord-017954-vobslprh	73	17	therefore	therefore	RB
cord-017954-vobslprh	73	18	might	may	MD
cord-017954-vobslprh	73	19	require	require	VB
cord-017954-vobslprh	73	20	less	less	JJR
cord-017954-vobslprh	73	21	cell	cell	NN
cord-017954-vobslprh	73	22	manipulation	manipulation	NN
cord-017954-vobslprh	73	23	in	in	IN
cord-017954-vobslprh	73	24	vitro	vitro	FW
cord-017954-vobslprh	73	25	for	for	IN
cord-017954-vobslprh	73	26	adoptive	adoptive	JJ
cord-017954-vobslprh	73	27	transfer	transfer	NN
cord-017954-vobslprh	73	28	studies	study	NNS
cord-017954-vobslprh	73	29	.	.	.
cord-017954-vobslprh	74	1	Although	although	IN
cord-017954-vobslprh	74	2	there	there	EX
cord-017954-vobslprh	74	3	is	be	VBZ
cord-017954-vobslprh	74	4	a	a	DT
cord-017954-vobslprh	74	5	predominance	predominance	NN
cord-017954-vobslprh	74	6	of	of	IN
cord-017954-vobslprh	74	7	EAE	EAE	NNP
cord-017954-vobslprh	74	8	papers	paper	NNS
cord-017954-vobslprh	74	9	investigating	investigate	VBG
cord-017954-vobslprh	74	10	the	the	DT
cord-017954-vobslprh	74	11	role	role	NN
cord-017954-vobslprh	74	12	of	of	IN
cord-017954-vobslprh	74	13	myelinspecific	myelinspecific	NN
cord-017954-vobslprh	74	14	CD4þ	CD4þ	NNP
cord-017954-vobslprh	74	15	T	T	NNP
cord-017954-vobslprh	74	16	cells	cell	NNS
cord-017954-vobslprh	74	17	in	in	IN
cord-017954-vobslprh	74	18	EAE	EAE	NNP
cord-017954-vobslprh	74	19	,	,	,
cord-017954-vobslprh	74	20	MS	MS	NNP
cord-017954-vobslprh	74	21	lesions	lesion	NNS
cord-017954-vobslprh	74	22	have	have	VBP
cord-017954-vobslprh	74	23	been	be	VBN
cord-017954-vobslprh	74	24	reported	report	VBN
cord-017954-vobslprh	74	25	to	to	TO
cord-017954-vobslprh	74	26	contain	contain	VB
cord-017954-vobslprh	74	27	greater	great	JJR
cord-017954-vobslprh	74	28	numbers	number	NNS
cord-017954-vobslprh	74	29	of	of	IN
cord-017954-vobslprh	74	30	CD8þ	CD8þ	NNP
cord-017954-vobslprh	74	31	T	T	NNP
cord-017954-vobslprh	74	32	cells	cell	NNS
cord-017954-vobslprh	74	33	compared	compare	VBN
cord-017954-vobslprh	74	34	with	with	IN
cord-017954-vobslprh	74	35	CD4þ	CD4þ	NNP
cord-017954-vobslprh	74	36	T	T	NNP
cord-017954-vobslprh	74	37	cells	cell	NNS
cord-017954-vobslprh	74	38	[	[	-LRB-
cord-017954-vobslprh	74	39	6	6	CD
cord-017954-vobslprh	74	40	,	,	,
cord-017954-vobslprh	74	41	25	25	CD
cord-017954-vobslprh	74	42	,	,	,
cord-017954-vobslprh	74	43	26	26	CD
cord-017954-vobslprh	74	44	]	]	-RRB-
cord-017954-vobslprh	74	45	.	.	.
cord-017954-vobslprh	75	1	However	however	RB
cord-017954-vobslprh	75	2	,	,	,
cord-017954-vobslprh	75	3	the	the	DT
cord-017954-vobslprh	75	4	function	function	NN
cord-017954-vobslprh	75	5	of	of	IN
cord-017954-vobslprh	75	6	CD8	CD8	NNP
cord-017954-vobslprh	75	7	T	T	NNP
cord-017954-vobslprh	75	8	cells	cell	NNS
cord-017954-vobslprh	75	9	in	in	IN
cord-017954-vobslprh	75	10	MS	MS	NNP
cord-017954-vobslprh	75	11	lesions	lesion	NNS
cord-017954-vobslprh	75	12	is	be	VBZ
cord-017954-vobslprh	75	13	unclear	unclear	JJ
cord-017954-vobslprh	75	14	,	,	,
cord-017954-vobslprh	75	15	and	and	CC
cord-017954-vobslprh	75	16	therefore	therefore	RB
cord-017954-vobslprh	75	17	,	,	,
cord-017954-vobslprh	75	18	the	the	DT
cord-017954-vobslprh	75	19	study	study	NN
cord-017954-vobslprh	75	20	of	of	IN
cord-017954-vobslprh	75	21	CD8þ	CD8þ	NNP
cord-017954-vobslprh	75	22	T	T	NNP
cord-017954-vobslprh	75	23	cells	cell	NNS
cord-017954-vobslprh	75	24	in	in	IN
cord-017954-vobslprh	75	25	EAE	EAE	NNP
cord-017954-vobslprh	75	26	is	be	VBZ
cord-017954-vobslprh	75	27	important	important	JJ
cord-017954-vobslprh	75	28	.	.	.
cord-017954-vobslprh	76	1	A	a	DT
cord-017954-vobslprh	76	2	number	number	NN
cord-017954-vobslprh	76	3	of	of	IN
cord-017954-vobslprh	76	4	EAE	EAE	NNP
cord-017954-vobslprh	76	5	models	model	NNS
cord-017954-vobslprh	76	6	induced	induce	VBN
cord-017954-vobslprh	76	7	by	by	IN
cord-017954-vobslprh	76	8	MHC	MHC	NNP
cord-017954-vobslprh	76	9	class	class	NN
cord-017954-vobslprh	76	10	I	i	NN
cord-017954-vobslprh	76	11	-	-	HYPH
cord-017954-vobslprh	76	12	specific	specific	JJ
cord-017954-vobslprh	76	13	CD8þ	CD8þ	NNP
cord-017954-vobslprh	76	14	T	T	NNP
cord-017954-vobslprh	76	15	cells	cell	NNS
cord-017954-vobslprh	76	16	have	have	VBP
cord-017954-vobslprh	76	17	been	be	VBN
cord-017954-vobslprh	76	18	reported	report	VBN
cord-017954-vobslprh	76	19	.	.	.
cord-017954-vobslprh	77	1	MBP79	MBP79	NNP
cord-017954-vobslprh	77	2	-	-	HYPH
cord-017954-vobslprh	77	3	87-specific	87-specific	CD
cord-017954-vobslprh	77	4	CD8þ	CD8þ	NNP
cord-017954-vobslprh	77	5	T	T	NNP
cord-017954-vobslprh	77	6	-	-	HYPH
cord-017954-vobslprh	77	7	cell	cell	NN
cord-017954-vobslprh	77	8	clones	clone	NNS
cord-017954-vobslprh	77	9	isolated	isolate	VBN
cord-017954-vobslprh	77	10	from	from	IN
cord-017954-vobslprh	77	11	MBP	MBP	NNP
cord-017954-vobslprh	77	12	-	-	HYPH
cord-017954-vobslprh	77	13	immunized	immunize	VBN
cord-017954-vobslprh	77	14	C3H	c3h	JJ
cord-017954-vobslprh	77	15	wild	wild	JJ
cord-017954-vobslprh	77	16	-	-	HYPH
cord-017954-vobslprh	77	17	type	type	NN
cord-017954-vobslprh	77	18	mice	mouse	NNS
cord-017954-vobslprh	77	19	induced	induce	VBD
cord-017954-vobslprh	77	20	EAE	EAE	NNP
cord-017954-vobslprh	77	21	with	with	IN
cord-017954-vobslprh	77	22	numerous	numerous	JJ
cord-017954-vobslprh	77	23	neurological	neurological	JJ
cord-017954-vobslprh	77	24	deficits	deficit	NNS
cord-017954-vobslprh	77	25	(	(	-LRB-
cord-017954-vobslprh	77	26	ataxia	ataxia	NN
cord-017954-vobslprh	77	27	,	,	,
cord-017954-vobslprh	77	28	spastic	spastic	JJ
cord-017954-vobslprh	77	29	reflexes	reflex	NNS
cord-017954-vobslprh	77	30	,	,	,
cord-017954-vobslprh	77	31	spinning	spin	VBG
cord-017954-vobslprh	77	32	)	)	-RRB-
cord-017954-vobslprh	77	33	as	as	RB
cord-017954-vobslprh	77	34	well	well	RB
cord-017954-vobslprh	77	35	as	as	IN
cord-017954-vobslprh	77	36	hindlimb	hindlimb	NN
cord-017954-vobslprh	77	37	paralysis	paralysis	NN
cord-017954-vobslprh	77	38	when	when	WRB
cord-017954-vobslprh	77	39	intravenously	intravenously	RB
cord-017954-vobslprh	77	40	injected	inject	VBD
cord-017954-vobslprh	77	41	into	into	IN
cord-017954-vobslprh	77	42	C3H	c3h	JJ
cord-017954-vobslprh	77	43	wild	wild	JJ
cord-017954-vobslprh	77	44	-	-	HYPH
cord-017954-vobslprh	77	45	type	type	NN
cord-017954-vobslprh	77	46	mice	mouse	NNS
cord-017954-vobslprh	77	47	[	[	-LRB-
cord-017954-vobslprh	77	48	27	27	CD
cord-017954-vobslprh	77	49	]	]	-RRB-
cord-017954-vobslprh	77	50	.	.	.
cord-017954-vobslprh	78	1	This	this	DT
cord-017954-vobslprh	78	2	form	form	NN
cord-017954-vobslprh	78	3	of	of	IN
cord-017954-vobslprh	78	4	EAE	EAE	NNP
cord-017954-vobslprh	78	5	was	be	VBD
cord-017954-vobslprh	78	6	very	very	RB
cord-017954-vobslprh	78	7	severe	severe	JJ
cord-017954-vobslprh	78	8	and	and	CC
cord-017954-vobslprh	78	9	all	all	DT
cord-017954-vobslprh	78	10	mice	mouse	NNS
cord-017954-vobslprh	78	11	were	be	VBD
cord-017954-vobslprh	78	12	moribund	moribund	JJ
cord-017954-vobslprh	78	13	by	by	IN
cord-017954-vobslprh	78	14	day	day	NN
cord-017954-vobslprh	78	15	14	14	CD
cord-017954-vobslprh	78	16	.	.	.
cord-017954-vobslprh	79	1	Interestingly	interestingly	RB
cord-017954-vobslprh	79	2	this	this	DT
cord-017954-vobslprh	79	3	model	model	NN
cord-017954-vobslprh	79	4	showed	show	VBD
cord-017954-vobslprh	79	5	different	different	JJ
cord-017954-vobslprh	79	6	clinical	clinical	JJ
cord-017954-vobslprh	79	7	symptoms	symptom	NNS
cord-017954-vobslprh	79	8	to	to	IN
cord-017954-vobslprh	79	9	the	the	DT
cord-017954-vobslprh	79	10	CD4þ	CD4þ	NNP
cord-017954-vobslprh	79	11	T	T	NNP
cord-017954-vobslprh	79	12	cell	cell	NN
cord-017954-vobslprh	79	13	-	-	HYPH
cord-017954-vobslprh	79	14	mediated	mediate	VBN
cord-017954-vobslprh	79	15	type	type	NN
cord-017954-vobslprh	79	16	of	of	IN
cord-017954-vobslprh	79	17	EAE	EAE	NNP
cord-017954-vobslprh	79	18	,	,	,
cord-017954-vobslprh	79	19	but	but	CC
cord-017954-vobslprh	79	20	importantly	importantly	RB
cord-017954-vobslprh	79	21	had	have	VBD
cord-017954-vobslprh	79	22	some	some	DT
cord-017954-vobslprh	79	23	similarities	similarity	NNS
cord-017954-vobslprh	79	24	to	to	IN
cord-017954-vobslprh	79	25	MS	MS	NNP
cord-017954-vobslprh	79	26	,	,	,
cord-017954-vobslprh	79	27	in	in	IN
cord-017954-vobslprh	79	28	that	that	DT
cord-017954-vobslprh	79	29	perivascular	perivascular	JJ
cord-017954-vobslprh	79	30	lesions	lesion	NNS
cord-017954-vobslprh	79	31	were	be	VBD
cord-017954-vobslprh	79	32	predominant	predominant	JJ
cord-017954-vobslprh	79	33	in	in	IN
cord-017954-vobslprh	79	34	the	the	DT
cord-017954-vobslprh	79	35	brain	brain	NN
cord-017954-vobslprh	79	36	,	,	,
cord-017954-vobslprh	79	37	compared	compare	VBN
cord-017954-vobslprh	79	38	with	with	IN
cord-017954-vobslprh	79	39	CD4þ	CD4þ	NNP
cord-017954-vobslprh	79	40	EAE	EAE	NNP
cord-017954-vobslprh	79	41	where	where	WRB
cord-017954-vobslprh	79	42	perivascular	perivascular	JJ
cord-017954-vobslprh	79	43	lesions	lesion	NNS
cord-017954-vobslprh	79	44	are	be	VBP
cord-017954-vobslprh	79	45	located	locate	VBN
cord-017954-vobslprh	79	46	in	in	IN
cord-017954-vobslprh	79	47	the	the	DT
cord-017954-vobslprh	79	48	spinal	spinal	JJ
cord-017954-vobslprh	79	49	cord	cord	NN
cord-017954-vobslprh	79	50	.	.	.
cord-017954-vobslprh	80	1	Another	another	DT
cord-017954-vobslprh	80	2	study	study	NN
cord-017954-vobslprh	80	3	reported	report	VBD
cord-017954-vobslprh	80	4	that	that	IN
cord-017954-vobslprh	80	5	MOG35	MOG35	NNP
cord-017954-vobslprh	80	6	-	-	HYPH
cord-017954-vobslprh	80	7	55-specific	55-specific	CD
cord-017954-vobslprh	80	8	CD8þ	CD8þ	NNP
cord-017954-vobslprh	80	9	T	T	NNP
cord-017954-vobslprh	80	10	cell	cell	NN
cord-017954-vobslprh	80	11	lines	line	NNS
cord-017954-vobslprh	80	12	could	could	MD
cord-017954-vobslprh	80	13	also	also	RB
cord-017954-vobslprh	80	14	induce	induce	VB
cord-017954-vobslprh	80	15	a	a	DT
cord-017954-vobslprh	80	16	severe	severe	JJ
cord-017954-vobslprh	80	17	,	,	,
cord-017954-vobslprh	80	18	chronic	chronic	JJ
cord-017954-vobslprh	80	19	form	form	NN
cord-017954-vobslprh	80	20	of	of	IN
cord-017954-vobslprh	80	21	EAE	EAE	NNP
cord-017954-vobslprh	80	22	when	when	WRB
cord-017954-vobslprh	80	23	adoptively	adoptively	RB
cord-017954-vobslprh	80	24	transferred	transfer	VBN
cord-017954-vobslprh	80	25	to	to	IN
cord-017954-vobslprh	80	26	naïve	naïve	JJ
cord-017954-vobslprh	80	27	C57BL/	c57bl/	NN
cord-017954-vobslprh	80	28	6	6	CD
cord-017954-vobslprh	80	29	mice	mouse	NNS
cord-017954-vobslprh	80	30	[	[	-LRB-
cord-017954-vobslprh	80	31	28	28	CD
cord-017954-vobslprh	80	32	]	]	-RRB-
cord-017954-vobslprh	80	33	.	.	.
cord-017954-vobslprh	81	1	In	in	IN
cord-017954-vobslprh	81	2	contrast	contrast	NN
cord-017954-vobslprh	81	3	to	to	IN
cord-017954-vobslprh	81	4	the	the	DT
cord-017954-vobslprh	81	5	MBP	MBP	NNP
cord-017954-vobslprh	81	6	-	-	HYPH
cord-017954-vobslprh	81	7	induced	induce	VBN
cord-017954-vobslprh	81	8	CD8	CD8	NNP
cord-017954-vobslprh	81	9	T	T	NNP
cord-017954-vobslprh	81	10	-	-	HYPH
cord-017954-vobslprh	81	11	cell	cell	NN
cord-017954-vobslprh	81	12	model	model	NN
cord-017954-vobslprh	81	13	of	of	IN
cord-017954-vobslprh	81	14	EAE	EAE	NNP
cord-017954-vobslprh	81	15	,	,	,
cord-017954-vobslprh	81	16	lesions	lesion	NNS
cord-017954-vobslprh	81	17	were	be	VBD
cord-017954-vobslprh	81	18	present	present	JJ
cord-017954-vobslprh	81	19	in	in	IN
cord-017954-vobslprh	81	20	both	both	CC
cord-017954-vobslprh	81	21	the	the	DT
cord-017954-vobslprh	81	22	spinal	spinal	JJ
cord-017954-vobslprh	81	23	cord	cord	NN
cord-017954-vobslprh	81	24	and	and	CC
cord-017954-vobslprh	81	25	brain	brain	NN
cord-017954-vobslprh	81	26	.	.	.
cord-017954-vobslprh	82	1	Differences	difference	NNS
cord-017954-vobslprh	82	2	in	in	IN
cord-017954-vobslprh	82	3	genetic	genetic	JJ
cord-017954-vobslprh	82	4	background	background	NN
cord-017954-vobslprh	82	5	,	,	,
cord-017954-vobslprh	82	6	availability	availability	NN
cord-017954-vobslprh	82	7	of	of	IN
cord-017954-vobslprh	82	8	myelin	myelin	JJ
cord-017954-vobslprh	82	9	antigens	antigen	NNS
cord-017954-vobslprh	82	10	in	in	IN
cord-017954-vobslprh	82	11	the	the	DT
cord-017954-vobslprh	82	12	CNS	CNS	NNP
cord-017954-vobslprh	82	13	,	,	,
cord-017954-vobslprh	82	14	or	or	CC
cord-017954-vobslprh	82	15	induction	induction	NN
cord-017954-vobslprh	82	16	procedure	procedure	NN
cord-017954-vobslprh	82	17	might	may	MD
cord-017954-vobslprh	82	18	explain	explain	VB
cord-017954-vobslprh	82	19	the	the	DT
cord-017954-vobslprh	82	20	differences	difference	NNS
cord-017954-vobslprh	82	21	observed	observe	VBN
cord-017954-vobslprh	82	22	between	between	IN
cord-017954-vobslprh	82	23	the	the	DT
cord-017954-vobslprh	82	24	two	two	CD
cord-017954-vobslprh	82	25	models	model	NNS
cord-017954-vobslprh	82	26	.	.	.
cord-017954-vobslprh	83	1	In	in	IN
cord-017954-vobslprh	83	2	contrast	contrast	NN
cord-017954-vobslprh	83	3	to	to	IN
cord-017954-vobslprh	83	4	these	these	DT
cord-017954-vobslprh	83	5	early	early	JJ
cord-017954-vobslprh	83	6	CD8	CD8	NNP
cord-017954-vobslprh	83	7	studies	study	NNS
cord-017954-vobslprh	83	8	,	,	,
cord-017954-vobslprh	83	9	more	more	JJR
cord-017954-vobslprh	83	10	recent	recent	JJ
cord-017954-vobslprh	83	11	investigations	investigation	NNS
cord-017954-vobslprh	83	12	have	have	VBP
cord-017954-vobslprh	83	13	indicated	indicate	VBN
cord-017954-vobslprh	83	14	inhibitory	inhibitory	JJ
cord-017954-vobslprh	83	15	roles	role	NNS
cord-017954-vobslprh	83	16	for	for	IN
cord-017954-vobslprh	83	17	CD8	CD8	NNP
cord-017954-vobslprh	83	18	T	T	NNP
cord-017954-vobslprh	83	19	cells	cell	NNS
cord-017954-vobslprh	83	20	in	in	IN
cord-017954-vobslprh	83	21	EAE	EAE	NNP
cord-017954-vobslprh	83	22	:	:	:
cord-017954-vobslprh	83	23	neuroantigen	neuroantigen	JJ
cord-017954-vobslprh	83	24	-	-	HYPH
cord-017954-vobslprh	83	25	specific	specific	JJ
cord-017954-vobslprh	83	26	autoregulatory	autoregulatory	NN
cord-017954-vobslprh	83	27	CD8þ	CD8þ	NNP
cord-017954-vobslprh	83	28	T	T	NNP
cord-017954-vobslprh	83	29	cells	cell	NNS
cord-017954-vobslprh	83	30	inhibited	inhibit	VBD
cord-017954-vobslprh	83	31	autoimmune	autoimmune	JJ
cord-017954-vobslprh	83	32	demyelination	demyelination	NN
cord-017954-vobslprh	83	33	by	by	IN
cord-017954-vobslprh	83	34	modulating	modulate	VBG
cord-017954-vobslprh	83	35	dendritic	dendritic	JJ
cord-017954-vobslprh	83	36	cell	cell	NN
cord-017954-vobslprh	83	37	functions	function	NNS
cord-017954-vobslprh	83	38	[	[	-LRB-
cord-017954-vobslprh	83	39	29	29	CD
cord-017954-vobslprh	83	40	]	]	-RRB-
cord-017954-vobslprh	83	41	and	and	CC
cord-017954-vobslprh	84	1	IL-15-dependent	il-15-dependent	DT
cord-017954-vobslprh	84	2	CD8þ	CD8þ	NNP
cord-017954-vobslprh	84	3	CD122þ	CD122þ	NNP
cord-017954-vobslprh	84	4	T	t	NN
cord-017954-vobslprh	84	5	cells	cell	NNS
cord-017954-vobslprh	84	6	ameliorated	ameliorate	VBD
cord-017954-vobslprh	84	7	EAE	EAE	NNP
cord-017954-vobslprh	84	8	by	by	IN
cord-017954-vobslprh	84	9	reducing	reduce	VBG
cord-017954-vobslprh	84	10	IL-17	IL-17	NNP
cord-017954-vobslprh	84	11	production	production	NN
cord-017954-vobslprh	84	12	by	by	IN
cord-017954-vobslprh	84	13	CD4þ	CD4þ	NNP
cord-017954-vobslprh	84	14	T	T	NNP
cord-017954-vobslprh	84	15	cells	cell	NNS
cord-017954-vobslprh	84	16	[	[	-LRB-
cord-017954-vobslprh	84	17	30	30	CD
cord-017954-vobslprh	84	18	]	]	-RRB-
cord-017954-vobslprh	84	19	.	.	.
cord-017954-vobslprh	85	1	Humanized	humanized	JJ
cord-017954-vobslprh	85	2	mouse	mouse	NN
cord-017954-vobslprh	85	3	models	model	NNS
cord-017954-vobslprh	85	4	have	have	VBP
cord-017954-vobslprh	85	5	also	also	RB
cord-017954-vobslprh	85	6	been	be	VBN
cord-017954-vobslprh	85	7	developed	develop	VBN
cord-017954-vobslprh	85	8	to	to	TO
cord-017954-vobslprh	85	9	study	study	VB
cord-017954-vobslprh	85	10	the	the	DT
cord-017954-vobslprh	85	11	effect	effect	NN
cord-017954-vobslprh	85	12	of	of	IN
cord-017954-vobslprh	85	13	MS	MS	NNP
cord-017954-vobslprh	85	14	-	-	HYPH
cord-017954-vobslprh	85	15	related	relate	VBN
cord-017954-vobslprh	85	16	myelin	myelin	NN
cord-017954-vobslprh	85	17	epitopes	epitope	NNS
cord-017954-vobslprh	85	18	presented	present	VBN
cord-017954-vobslprh	85	19	to	to	IN
cord-017954-vobslprh	85	20	CD8	CD8	NNP
cord-017954-vobslprh	85	21	T	T	NNP
cord-017954-vobslprh	85	22	cells	cell	NNS
cord-017954-vobslprh	85	23	by	by	IN
cord-017954-vobslprh	85	24	human	human	JJ
cord-017954-vobslprh	85	25	HLA	HLA	NNP
cord-017954-vobslprh	85	26	molecules	molecule	NNS
cord-017954-vobslprh	85	27	and	and	CC
cord-017954-vobslprh	85	28	showed	show	VBD
cord-017954-vobslprh	85	29	that	that	IN
cord-017954-vobslprh	85	30	MOG181	MOG181	NNP
cord-017954-vobslprh	85	31	-	-	HYPH
cord-017954-vobslprh	85	32	189	189	CD
cord-017954-vobslprh	85	33	presented	present	VBN
cord-017954-vobslprh	85	34	by	by	IN
cord-017954-vobslprh	85	35	HLA	HLA	NNP
cord-017954-vobslprh	85	36	-	-	HYPH
cord-017954-vobslprh	85	37	A*201	A*201	NNP
cord-017954-vobslprh	85	38	to	to	IN
cord-017954-vobslprh	85	39	MOG	mog	NN
cord-017954-vobslprh	85	40	-	-	HYPH
cord-017954-vobslprh	85	41	specific	specific	JJ
cord-017954-vobslprh	85	42	CD8	CD8	NNP
cord-017954-vobslprh	85	43	T	T	NNP
cord-017954-vobslprh	85	44	cells	cell	NNS
cord-017954-vobslprh	85	45	exacerbated	exacerbate	VBD
cord-017954-vobslprh	85	46	CD4	CD4	NNP
cord-017954-vobslprh	85	47	T	T	NNP
cord-017954-vobslprh	85	48	cell	cell	NN
cord-017954-vobslprh	85	49	-	-	HYPH
cord-017954-vobslprh	85	50	induced	induce	VBN
cord-017954-vobslprh	85	51	EAE	EAE	NNP
cord-017954-vobslprh	85	52	[	[	-LRB-
cord-017954-vobslprh	85	53	31	31	CD
cord-017954-vobslprh	85	54	]	]	-RRB-
cord-017954-vobslprh	85	55	.	.	.
cord-017954-vobslprh	86	1	Overall	overall	RB
cord-017954-vobslprh	86	2	,	,	,
cord-017954-vobslprh	86	3	these	these	DT
cord-017954-vobslprh	86	4	models	model	NNS
cord-017954-vobslprh	86	5	of	of	IN
cord-017954-vobslprh	86	6	CD8	CD8	NNP
cord-017954-vobslprh	86	7	T	T	NNP
cord-017954-vobslprh	86	8	cell	cell	NN
cord-017954-vobslprh	86	9	-	-	HYPH
cord-017954-vobslprh	86	10	induced	induce	VBN
cord-017954-vobslprh	86	11	EAE	EAE	NNP
cord-017954-vobslprh	86	12	are	be	VBP
cord-017954-vobslprh	86	13	important	important	JJ
cord-017954-vobslprh	86	14	for	for	IN
cord-017954-vobslprh	86	15	determining	determine	VBG
cord-017954-vobslprh	86	16	the	the	DT
cord-017954-vobslprh	86	17	function	function	NN
cord-017954-vobslprh	86	18	of	of	IN
cord-017954-vobslprh	86	19	CD8	CD8	NNP
cord-017954-vobslprh	86	20	T	T	NNP
cord-017954-vobslprh	86	21	cells	cell	NNS
cord-017954-vobslprh	86	22	during	during	IN
cord-017954-vobslprh	86	23	CNS	CNS	NNP
cord-017954-vobslprh	86	24	autoimmune	autoimmune	JJ
cord-017954-vobslprh	86	25	disease	disease	NN
cord-017954-vobslprh	86	26	,	,	,
cord-017954-vobslprh	86	27	i.e.	i.e.	FW
cord-017954-vobslprh	86	28	pathological	pathological	JJ
cord-017954-vobslprh	86	29	versus	versus	IN
cord-017954-vobslprh	86	30	inhibitory	inhibitory	JJ
cord-017954-vobslprh	86	31	/	/	SYM
cord-017954-vobslprh	86	32	regulatory	regulatory	JJ
cord-017954-vobslprh	86	33	effects	effect	NNS
cord-017954-vobslprh	86	34	,	,	,
cord-017954-vobslprh	86	35	and	and	CC
cord-017954-vobslprh	86	36	have	have	VBP
cord-017954-vobslprh	86	37	an	an	DT
cord-017954-vobslprh	86	38	advantage	advantage	NN
cord-017954-vobslprh	86	39	over	over	IN
cord-017954-vobslprh	87	1	CD4	CD4	NNP
cord-017954-vobslprh	87	2	T	T	NNP
cord-017954-vobslprh	87	3	cellinduced	cellinduce	VBD
cord-017954-vobslprh	87	4	EAE	EAE	NNP
cord-017954-vobslprh	87	5	in	in	IN
cord-017954-vobslprh	87	6	that	that	IN
cord-017954-vobslprh	87	7	the	the	DT
cord-017954-vobslprh	87	8	target	target	NN
cord-017954-vobslprh	87	9	organ	organ	NN
cord-017954-vobslprh	87	10	is	be	VBZ
cord-017954-vobslprh	87	11	predominantly	predominantly	RB
cord-017954-vobslprh	87	12	the	the	DT
cord-017954-vobslprh	87	13	brain	brain	NN
cord-017954-vobslprh	87	14	,	,	,
cord-017954-vobslprh	87	15	similar	similar	JJ
cord-017954-vobslprh	87	16	to	to	IN
cord-017954-vobslprh	87	17	that	that	DT
cord-017954-vobslprh	87	18	in	in	IN
cord-017954-vobslprh	87	19	MS	MS	NNP
cord-017954-vobslprh	87	20	.	.	.
cord-017954-vobslprh	88	1	A	a	DT
cord-017954-vobslprh	88	2	number	number	NN
cord-017954-vobslprh	88	3	of	of	IN
cord-017954-vobslprh	88	4	spontaneous	spontaneous	JJ
cord-017954-vobslprh	88	5	mouse	mouse	NN
cord-017954-vobslprh	88	6	models	model	NNS
cord-017954-vobslprh	88	7	of	of	IN
cord-017954-vobslprh	88	8	EAE	EAE	NNP
cord-017954-vobslprh	88	9	have	have	VBP
cord-017954-vobslprh	88	10	been	be	VBN
cord-017954-vobslprh	88	11	developed	develop	VBN
cord-017954-vobslprh	88	12	by	by	IN
cord-017954-vobslprh	88	13	the	the	DT
cord-017954-vobslprh	88	14	transgenic	transgenic	JJ
cord-017954-vobslprh	88	15	expression	expression	NN
cord-017954-vobslprh	88	16	of	of	IN
cord-017954-vobslprh	88	17	T	t	NN
cord-017954-vobslprh	88	18	-	-	HYPH
cord-017954-vobslprh	88	19	cell	cell	NN
cord-017954-vobslprh	88	20	receptors	receptor	NNS
cord-017954-vobslprh	88	21	(	(	-LRB-
cord-017954-vobslprh	88	22	TCR	TCR	NNP
cord-017954-vobslprh	88	23	)	)	-RRB-
cord-017954-vobslprh	88	24	specific	specific	JJ
cord-017954-vobslprh	88	25	for	for	IN
cord-017954-vobslprh	88	26	myelin	myelin	NN
cord-017954-vobslprh	88	27	antigens	antigen	NNS
cord-017954-vobslprh	88	28	(	(	-LRB-
cord-017954-vobslprh	88	29	PLP	PLP	NNP
cord-017954-vobslprh	88	30	,	,	,
cord-017954-vobslprh	88	31	MOG	MOG	NNP
cord-017954-vobslprh	88	32	,	,	,
cord-017954-vobslprh	88	33	or	or	CC
cord-017954-vobslprh	88	34	MOG	MOG	NNP
cord-017954-vobslprh	88	35	)	)	-RRB-
cord-017954-vobslprh	88	36	in	in	IN
cord-017954-vobslprh	88	37	T	T	NNP
cord-017954-vobslprh	88	38	cells	cell	NNS
cord-017954-vobslprh	88	39	that	that	WDT
cord-017954-vobslprh	88	40	overcome	overcome	VBP
cord-017954-vobslprh	88	41	the	the	DT
cord-017954-vobslprh	88	42	negative	negative	JJ
cord-017954-vobslprh	88	43	selection	selection	NN
cord-017954-vobslprh	88	44	of	of	IN
cord-017954-vobslprh	88	45	autoreactive	autoreactive	JJ
cord-017954-vobslprh	88	46	T	t	NN
cord-017954-vobslprh	88	47	cells	cell	NNS
cord-017954-vobslprh	88	48	in	in	IN
cord-017954-vobslprh	88	49	the	the	DT
cord-017954-vobslprh	88	50	thymus	thymus	NN
cord-017954-vobslprh	88	51	(	(	-LRB-
cord-017954-vobslprh	88	52	reviewed	review	VBN
cord-017954-vobslprh	88	53	by	by	IN
cord-017954-vobslprh	88	54	Croxford	Croxford	NNP
cord-017954-vobslprh	88	55	2011	2011	CD
cord-017954-vobslprh	88	56	)	)	-RRB-
cord-017954-vobslprh	89	1	[	[	-LRB-
cord-017954-vobslprh	89	2	32	32	CD
cord-017954-vobslprh	89	3	]	]	-RRB-
cord-017954-vobslprh	89	4	.	.	.
cord-017954-vobslprh	90	1	Therefore	therefore	RB
cord-017954-vobslprh	90	2	,	,	,
cord-017954-vobslprh	90	3	these	these	DT
cord-017954-vobslprh	90	4	models	model	NNS
cord-017954-vobslprh	90	5	represent	represent	VBP
cord-017954-vobslprh	90	6	a	a	DT
cord-017954-vobslprh	90	7	more	more	RBR
cord-017954-vobslprh	90	8	"	"	``
cord-017954-vobslprh	90	9	natural	natural	JJ
cord-017954-vobslprh	90	10	"	"	''
cord-017954-vobslprh	90	11	type	type	NN
cord-017954-vobslprh	90	12	of	of	IN
cord-017954-vobslprh	90	13	disease	disease	NN
cord-017954-vobslprh	90	14	and	and	CC
cord-017954-vobslprh	90	15	are	be	VBP
cord-017954-vobslprh	90	16	useful	useful	JJ
cord-017954-vobslprh	90	17	for	for	IN
cord-017954-vobslprh	90	18	examining	examine	VBG
cord-017954-vobslprh	90	19	the	the	DT
cord-017954-vobslprh	90	20	role	role	NN
cord-017954-vobslprh	90	21	of	of	IN
cord-017954-vobslprh	90	22	autoimmune	autoimmune	JJ
cord-017954-vobslprh	90	23	T	t	NN
cord-017954-vobslprh	90	24	-	-	HYPH
cord-017954-vobslprh	90	25	cell	cell	NN
cord-017954-vobslprh	90	26	activation	activation	NN
cord-017954-vobslprh	90	27	by	by	IN
cord-017954-vobslprh	90	28	environmental	environmental	JJ
cord-017954-vobslprh	90	29	stimuli	stimulus	NNS
cord-017954-vobslprh	90	30	.	.	.
cord-017954-vobslprh	91	1	However	however	RB
cord-017954-vobslprh	91	2	,	,	,
cord-017954-vobslprh	91	3	depending	depend	VBG
cord-017954-vobslprh	91	4	on	on	IN
cord-017954-vobslprh	91	5	the	the	DT
cord-017954-vobslprh	91	6	type	type	NN
cord-017954-vobslprh	91	7	of	of	IN
cord-017954-vobslprh	91	8	study	study	NN
cord-017954-vobslprh	91	9	involved	involve	VBN
cord-017954-vobslprh	91	10	,	,	,
cord-017954-vobslprh	91	11	for	for	IN
cord-017954-vobslprh	91	12	example	example	NN
cord-017954-vobslprh	91	13	,	,	,
cord-017954-vobslprh	91	14	drug	drug	NN
cord-017954-vobslprh	91	15	efficacy	efficacy	NN
cord-017954-vobslprh	91	16	testing	testing	NN
cord-017954-vobslprh	91	17	,	,	,
cord-017954-vobslprh	91	18	the	the	DT
cord-017954-vobslprh	91	19	use	use	NN
cord-017954-vobslprh	91	20	of	of	IN
cord-017954-vobslprh	91	21	spontaneous	spontaneous	JJ
cord-017954-vobslprh	91	22	EAE	EAE	NNP
cord-017954-vobslprh	91	23	models	model	NNS
cord-017954-vobslprh	91	24	is	be	VBZ
cord-017954-vobslprh	91	25	not	not	RB
cord-017954-vobslprh	91	26	recommended	recommend	VBN
cord-017954-vobslprh	91	27	because	because	IN
cord-017954-vobslprh	91	28	of	of	IN
cord-017954-vobslprh	91	29	the	the	DT
cord-017954-vobslprh	91	30	wide	wide	JJ
cord-017954-vobslprh	91	31	variance	variance	NN
cord-017954-vobslprh	91	32	in	in	IN
cord-017954-vobslprh	91	33	disease	disease	NN
cord-017954-vobslprh	91	34	onset	onset	NN
cord-017954-vobslprh	91	35	and	and	CC
cord-017954-vobslprh	91	36	severity	severity	NN
cord-017954-vobslprh	91	37	.	.	.
cord-017954-vobslprh	92	1	The	the	DT
cord-017954-vobslprh	92	2	advantages	advantage	NNS
cord-017954-vobslprh	92	3	of	of	IN
cord-017954-vobslprh	92	4	EAE	EAE	NNP
cord-017954-vobslprh	92	5	are	be	VBP
cord-017954-vobslprh	92	6	its	-PRON-	PRP$
cord-017954-vobslprh	92	7	robust	robust	JJ
cord-017954-vobslprh	92	8	and	and	CC
cord-017954-vobslprh	92	9	reproducible	reproducible	JJ
cord-017954-vobslprh	92	10	disease	disease	NN
cord-017954-vobslprh	92	11	course	course	NN
cord-017954-vobslprh	92	12	that	that	WDT
cord-017954-vobslprh	92	13	is	be	VBZ
cord-017954-vobslprh	92	14	useful	useful	JJ
cord-017954-vobslprh	92	15	for	for	IN
cord-017954-vobslprh	92	16	studying	study	VBG
cord-017954-vobslprh	92	17	the	the	DT
cord-017954-vobslprh	92	18	early	early	JJ
cord-017954-vobslprh	92	19	stages	stage	NNS
cord-017954-vobslprh	92	20	of	of	IN
cord-017954-vobslprh	92	21	disease	disease	NN
cord-017954-vobslprh	92	22	initiation	initiation	NN
cord-017954-vobslprh	92	23	;	;	:
cord-017954-vobslprh	92	24	the	the	DT
cord-017954-vobslprh	92	25	activation	activation	NN
cord-017954-vobslprh	92	26	of	of	IN
cord-017954-vobslprh	92	27	immune	immune	JJ
cord-017954-vobslprh	92	28	cells	cell	NNS
cord-017954-vobslprh	92	29	,	,	,
cord-017954-vobslprh	92	30	especially	especially	RB
cord-017954-vobslprh	92	31	antigen	antigen	NN
cord-017954-vobslprh	92	32	-	-	HYPH
cord-017954-vobslprh	92	33	specific	specific	JJ
cord-017954-vobslprh	92	34	T	t	NN
cord-017954-vobslprh	92	35	cells	cell	NNS
cord-017954-vobslprh	92	36	;	;	:
cord-017954-vobslprh	92	37	as	as	RB
cord-017954-vobslprh	92	38	well	well	RB
cord-017954-vobslprh	92	39	as	as	IN
cord-017954-vobslprh	92	40	mechanisms	mechanism	NNS
cord-017954-vobslprh	92	41	in	in	IN
cord-017954-vobslprh	92	42	the	the	DT
cord-017954-vobslprh	92	43	effector	effector	NN
cord-017954-vobslprh	92	44	phase	phase	NN
cord-017954-vobslprh	92	45	such	such	JJ
cord-017954-vobslprh	92	46	as	as	IN
cord-017954-vobslprh	92	47	the	the	DT
cord-017954-vobslprh	92	48	role	role	NN
cord-017954-vobslprh	92	49	of	of	IN
cord-017954-vobslprh	92	50	resident	resident	JJ
cord-017954-vobslprh	92	51	CNS	CNS	NNP
cord-017954-vobslprh	92	52	cells	cell	NNS
cord-017954-vobslprh	92	53	,	,	,
cord-017954-vobslprh	92	54	regulatory	regulatory	JJ
cord-017954-vobslprh	92	55	T	t	NN
cord-017954-vobslprh	92	56	cells	cell	NNS
cord-017954-vobslprh	92	57	,	,	,
cord-017954-vobslprh	92	58	and	and	CC
cord-017954-vobslprh	92	59	other	other	JJ
cord-017954-vobslprh	92	60	regulatory	regulatory	JJ
cord-017954-vobslprh	92	61	mechanisms	mechanism	NNS
cord-017954-vobslprh	92	62	.	.	.
cord-017954-vobslprh	93	1	In	in	IN
cord-017954-vobslprh	93	2	addition	addition	NN
cord-017954-vobslprh	93	3	,	,	,
cord-017954-vobslprh	93	4	pathological	pathological	JJ
cord-017954-vobslprh	93	5	studies	study	NNS
cord-017954-vobslprh	93	6	at	at	IN
cord-017954-vobslprh	93	7	all	all	DT
cord-017954-vobslprh	93	8	stages	stage	NNS
cord-017954-vobslprh	93	9	of	of	IN
cord-017954-vobslprh	93	10	disease	disease	NN
cord-017954-vobslprh	93	11	can	can	MD
cord-017954-vobslprh	93	12	provide	provide	VB
cord-017954-vobslprh	93	13	important	important	JJ
cord-017954-vobslprh	93	14	information	information	NN
cord-017954-vobslprh	93	15	regarding	regard	VBG
cord-017954-vobslprh	93	16	sites	site	NNS
cord-017954-vobslprh	93	17	and	and	CC
cord-017954-vobslprh	93	18	mechanisms	mechanism	NNS
cord-017954-vobslprh	93	19	of	of	IN
cord-017954-vobslprh	93	20	demyelination	demyelination	NN
cord-017954-vobslprh	93	21	,	,	,
cord-017954-vobslprh	93	22	remyelination	remyelination	NN
cord-017954-vobslprh	93	23	,	,	,
cord-017954-vobslprh	93	24	nerve	nerve	NN
cord-017954-vobslprh	93	25	conduction	conduction	NN
cord-017954-vobslprh	93	26	block	block	NN
cord-017954-vobslprh	93	27	,	,	,
cord-017954-vobslprh	93	28	and	and	CC
cord-017954-vobslprh	93	29	axonal	axonal	JJ
cord-017954-vobslprh	93	30	loss	loss	NN
cord-017954-vobslprh	93	31	.	.	.
cord-017954-vobslprh	94	1	Furthermore	furthermore	RB
cord-017954-vobslprh	94	2	,	,	,
cord-017954-vobslprh	94	3	depending	depend	VBG
cord-017954-vobslprh	94	4	upon	upon	IN
cord-017954-vobslprh	94	5	the	the	DT
cord-017954-vobslprh	94	6	models	model	NNS
cord-017954-vobslprh	94	7	used	use	VBN
cord-017954-vobslprh	94	8	,	,	,
cord-017954-vobslprh	94	9	the	the	DT
cord-017954-vobslprh	94	10	different	different	JJ
cord-017954-vobslprh	94	11	mechanisms	mechanism	NNS
cord-017954-vobslprh	94	12	involved	involve	VBN
cord-017954-vobslprh	94	13	in	in	IN
cord-017954-vobslprh	94	14	relapsing	relapse	VBG
cord-017954-vobslprh	94	15	vs	vs	IN
cord-017954-vobslprh	94	16	chronic	chronic	JJ
cord-017954-vobslprh	94	17	forms	form	NNS
cord-017954-vobslprh	94	18	of	of	IN
cord-017954-vobslprh	94	19	disease	disease	NN
cord-017954-vobslprh	94	20	can	can	MD
cord-017954-vobslprh	94	21	be	be	VB
cord-017954-vobslprh	94	22	studied	study	VBN
cord-017954-vobslprh	94	23	.	.	.
cord-017954-vobslprh	95	1	The	the	DT
cord-017954-vobslprh	95	2	reader	reader	NN
cord-017954-vobslprh	95	3	is	be	VBZ
cord-017954-vobslprh	95	4	encouraged	encourage	VBN
cord-017954-vobslprh	95	5	to	to	TO
cord-017954-vobslprh	95	6	read	read	VB
cord-017954-vobslprh	95	7	review	review	NN
cord-017954-vobslprh	95	8	articles	article	NNS
cord-017954-vobslprh	95	9	describing	describe	VBG
cord-017954-vobslprh	95	10	the	the	DT
cord-017954-vobslprh	95	11	specific	specific	JJ
cord-017954-vobslprh	95	12	induction	induction	NN
cord-017954-vobslprh	95	13	protocols	protocol	NNS
cord-017954-vobslprh	95	14	for	for	IN
cord-017954-vobslprh	95	15	the	the	DT
cord-017954-vobslprh	95	16	numerous	numerous	JJ
cord-017954-vobslprh	95	17	EAE	EAE	NNP
cord-017954-vobslprh	95	18	models	model	NNS
cord-017954-vobslprh	95	19	that	that	WDT
cord-017954-vobslprh	95	20	are	be	VBP
cord-017954-vobslprh	95	21	available	available	JJ
cord-017954-vobslprh	95	22	[	[	-LRB-
cord-017954-vobslprh	95	23	11	11	CD
cord-017954-vobslprh	95	24	,	,	,
cord-017954-vobslprh	95	25	12	12	CD
cord-017954-vobslprh	95	26	]	]	-RRB-
cord-017954-vobslprh	95	27	.	.	.
cord-017954-vobslprh	96	1	The	the	DT
cord-017954-vobslprh	96	2	most	most	RBS
cord-017954-vobslprh	96	3	significant	significant	JJ
cord-017954-vobslprh	96	4	disadvantage	disadvantage	NN
cord-017954-vobslprh	96	5	of	of	IN
cord-017954-vobslprh	96	6	EAE	EAE	NNP
cord-017954-vobslprh	96	7	is	be	VBZ
cord-017954-vobslprh	96	8	the	the	DT
cord-017954-vobslprh	96	9	location	location	NN
cord-017954-vobslprh	96	10	of	of	IN
cord-017954-vobslprh	96	11	pathology	pathology	NN
cord-017954-vobslprh	96	12	in	in	IN
cord-017954-vobslprh	96	13	spinal	spinal	JJ
cord-017954-vobslprh	96	14	cord	cord	NN
cord-017954-vobslprh	96	15	,	,	,
cord-017954-vobslprh	96	16	unlike	unlike	IN
cord-017954-vobslprh	96	17	MS	MS	NNP
cord-017954-vobslprh	96	18	,	,	,
cord-017954-vobslprh	96	19	where	where	WRB
cord-017954-vobslprh	96	20	many	many	JJ
cord-017954-vobslprh	96	21	lesions	lesion	NNS
cord-017954-vobslprh	96	22	occur	occur	VBP
cord-017954-vobslprh	96	23	in	in	IN
cord-017954-vobslprh	96	24	the	the	DT
cord-017954-vobslprh	96	25	brain	brain	NN
cord-017954-vobslprh	96	26	.	.	.
cord-017954-vobslprh	97	1	Furthermore	furthermore	RB
cord-017954-vobslprh	97	2	,	,	,
cord-017954-vobslprh	97	3	although	although	IN
cord-017954-vobslprh	97	4	EAE	EAE	NNP
cord-017954-vobslprh	97	5	is	be	VBZ
cord-017954-vobslprh	97	6	clearly	clearly	RB
cord-017954-vobslprh	97	7	an	an	DT
cord-017954-vobslprh	97	8	autoimmune	autoimmune	JJ
cord-017954-vobslprh	97	9	disease	disease	NN
cord-017954-vobslprh	97	10	,	,	,
cord-017954-vobslprh	97	11	MS	MS	NNP
cord-017954-vobslprh	97	12	does	do	VBZ
cord-017954-vobslprh	97	13	not	not	RB
cord-017954-vobslprh	97	14	have	have	VB
cord-017954-vobslprh	97	15	all	all	PDT
cord-017954-vobslprh	97	16	the	the	DT
cord-017954-vobslprh	97	17	hallmarks	hallmark	NNS
cord-017954-vobslprh	97	18	of	of	IN
cord-017954-vobslprh	97	19	an	an	DT
cord-017954-vobslprh	97	20	autoimmune	autoimmune	JJ
cord-017954-vobslprh	97	21	disease	disease	NN
cord-017954-vobslprh	97	22	,	,	,
cord-017954-vobslprh	97	23	and	and	CC
cord-017954-vobslprh	97	24	evidence	evidence	NN
cord-017954-vobslprh	97	25	for	for	IN
cord-017954-vobslprh	97	26	a	a	DT
cord-017954-vobslprh	97	27	specific	specific	JJ
cord-017954-vobslprh	97	28	immunodominant	immunodominant	JJ
cord-017954-vobslprh	97	29	myelin	myelin	NN
cord-017954-vobslprh	97	30	antigen	antigen	NN
cord-017954-vobslprh	97	31	is	be	VBZ
cord-017954-vobslprh	97	32	lacking	lack	VBG
cord-017954-vobslprh	97	33	.	.	.
cord-017954-vobslprh	98	1	Although	although	IN
cord-017954-vobslprh	98	2	CD4þ	CD4þ	NNP
cord-017954-vobslprh	98	3	T	T	NNP
cord-017954-vobslprh	98	4	cells	cell	NNS
cord-017954-vobslprh	98	5	are	be	VBP
cord-017954-vobslprh	98	6	critical	critical	JJ
cord-017954-vobslprh	98	7	for	for	IN
cord-017954-vobslprh	98	8	disease	disease	NN
cord-017954-vobslprh	98	9	induction	induction	NN
cord-017954-vobslprh	98	10	in	in	IN
cord-017954-vobslprh	98	11	most	most	JJS
cord-017954-vobslprh	98	12	EAE	EAE	NNP
cord-017954-vobslprh	98	13	models	model	NNS
cord-017954-vobslprh	98	14	,	,	,
cord-017954-vobslprh	98	15	their	-PRON-	PRP$
cord-017954-vobslprh	98	16	role	role	NN
cord-017954-vobslprh	98	17	in	in	IN
cord-017954-vobslprh	98	18	MS	MS	NNP
cord-017954-vobslprh	98	19	is	be	VBZ
cord-017954-vobslprh	98	20	less	less	RBR
cord-017954-vobslprh	98	21	clear	clear	JJ
cord-017954-vobslprh	98	22	,	,	,
cord-017954-vobslprh	98	23	where	where	WRB
cord-017954-vobslprh	98	24	many	many	JJ
cord-017954-vobslprh	98	25	other	other	JJ
cord-017954-vobslprh	98	26	types	type	NNS
cord-017954-vobslprh	98	27	of	of	IN
cord-017954-vobslprh	98	28	immune	immune	JJ
cord-017954-vobslprh	98	29	cells	cell	NNS
cord-017954-vobslprh	98	30	such	such	JJ
cord-017954-vobslprh	98	31	as	as	IN
cord-017954-vobslprh	98	32	CD8þ	CD8þ	NNP
cord-017954-vobslprh	98	33	T	T	NNP
cord-017954-vobslprh	98	34	cells	cell	NNS
cord-017954-vobslprh	98	35	,	,	,
cord-017954-vobslprh	98	36	B	b	NN
cord-017954-vobslprh	98	37	cells	cell	NNS
cord-017954-vobslprh	98	38	,	,	,
cord-017954-vobslprh	98	39	and	and	CC
cord-017954-vobslprh	98	40	monocytes	monocyte	VBZ
cord-017954-vobslprh	98	41	probably	probably	RB
cord-017954-vobslprh	98	42	also	also	RB
cord-017954-vobslprh	98	43	have	have	VBP
cord-017954-vobslprh	98	44	important	important	JJ
cord-017954-vobslprh	98	45	roles	role	NNS
cord-017954-vobslprh	98	46	.	.	.
cord-017954-vobslprh	99	1	For	for	IN
cord-017954-vobslprh	99	2	example	example	NN
cord-017954-vobslprh	99	3	,	,	,
cord-017954-vobslprh	99	4	B	b	NN
cord-017954-vobslprh	99	5	cells	cell	NNS
cord-017954-vobslprh	99	6	have	have	VBP
cord-017954-vobslprh	99	7	little	little	JJ
cord-017954-vobslprh	99	8	or	or	CC
cord-017954-vobslprh	99	9	no	no	DT
cord-017954-vobslprh	99	10	role	role	NN
cord-017954-vobslprh	99	11	in	in	IN
cord-017954-vobslprh	99	12	many	many	JJ
cord-017954-vobslprh	99	13	EAE	EAE	NNP
cord-017954-vobslprh	99	14	models	model	NNS
cord-017954-vobslprh	99	15	,	,	,
cord-017954-vobslprh	99	16	at	at	IN
cord-017954-vobslprh	99	17	least	least	JJS
cord-017954-vobslprh	99	18	at	at	IN
cord-017954-vobslprh	99	19	the	the	DT
cord-017954-vobslprh	99	20	early	early	JJ
cord-017954-vobslprh	99	21	time	time	NN
cord-017954-vobslprh	99	22	points	point	NNS
cord-017954-vobslprh	99	23	usually	usually	RB
cord-017954-vobslprh	99	24	studied	study	VBD
cord-017954-vobslprh	99	25	;	;	:
cord-017954-vobslprh	99	26	however	however	RB
cord-017954-vobslprh	99	27	,	,	,
cord-017954-vobslprh	99	28	their	-PRON-	PRP$
cord-017954-vobslprh	99	29	importance	importance	NN
cord-017954-vobslprh	99	30	in	in	IN
cord-017954-vobslprh	99	31	MS	MS	NNP
cord-017954-vobslprh	99	32	is	be	VBZ
cord-017954-vobslprh	99	33	suggested	suggest	VBN
cord-017954-vobslprh	99	34	by	by	IN
cord-017954-vobslprh	99	35	the	the	DT
cord-017954-vobslprh	99	36	beneficial	beneficial	JJ
cord-017954-vobslprh	99	37	effects	effect	NNS
cord-017954-vobslprh	99	38	of	of	IN
cord-017954-vobslprh	99	39	anti	anti	JJ
cord-017954-vobslprh	99	40	-	-	JJ
cord-017954-vobslprh	99	41	CD20	cd20	JJ
cord-017954-vobslprh	99	42	therapy	therapy	NN
cord-017954-vobslprh	99	43	in	in	IN
cord-017954-vobslprh	99	44	some	some	DT
cord-017954-vobslprh	99	45	MS	MS	NNP
cord-017954-vobslprh	99	46	patients	patient	NNS
cord-017954-vobslprh	99	47	[	[	-LRB-
cord-017954-vobslprh	99	48	33	33	CD
cord-017954-vobslprh	99	49	]	]	-RRB-
cord-017954-vobslprh	99	50	.	.	.
cord-017954-vobslprh	100	1	EAE	EAE	NNP
cord-017954-vobslprh	100	2	is	be	VBZ
cord-017954-vobslprh	100	3	a	a	DT
cord-017954-vobslprh	100	4	very	very	RB
cord-017954-vobslprh	100	5	useful	useful	JJ
cord-017954-vobslprh	100	6	tool	tool	NN
cord-017954-vobslprh	100	7	to	to	TO
cord-017954-vobslprh	100	8	test	test	VB
cord-017954-vobslprh	100	9	potential	potential	JJ
cord-017954-vobslprh	100	10	new	new	JJ
cord-017954-vobslprh	100	11	immunomodulatory	immunomodulatory	JJ
cord-017954-vobslprh	100	12	therapies	therapy	NNS
cord-017954-vobslprh	100	13	.	.	.
cord-017954-vobslprh	101	1	Although	although	IN
cord-017954-vobslprh	101	2	four	four	CD
cord-017954-vobslprh	101	3	approved	approve	VBN
cord-017954-vobslprh	101	4	MS	MS	NNP
cord-017954-vobslprh	101	5	treatments	treatment	NNS
cord-017954-vobslprh	101	6	were	be	VBD
cord-017954-vobslprh	101	7	studied	study	VBN
cord-017954-vobslprh	101	8	in	in	IN
cord-017954-vobslprh	101	9	EAE	EAE	NNP
cord-017954-vobslprh	101	10	(	(	-LRB-
cord-017954-vobslprh	101	11	natalizumab	natalizumab	NNP
cord-017954-vobslprh	101	12	,	,	,
cord-017954-vobslprh	101	13	mitoxantrone	mitoxantrone	NN
cord-017954-vobslprh	101	14	,	,	,
cord-017954-vobslprh	101	15	glatiramer	glatiramer	NN
cord-017954-vobslprh	101	16	acetate	acetate	NN
cord-017954-vobslprh	101	17	,	,	,
cord-017954-vobslprh	101	18	and	and	CC
cord-017954-vobslprh	101	19	fingolimod	fingolimod	NNP
cord-017954-vobslprh	101	20	)	)	-RRB-
cord-017954-vobslprh	101	21	,	,	,
cord-017954-vobslprh	101	22	the	the	DT
cord-017954-vobslprh	101	23	large	large	JJ
cord-017954-vobslprh	101	24	majority	majority	NN
cord-017954-vobslprh	101	25	of	of	IN
cord-017954-vobslprh	101	26	new	new	JJ
cord-017954-vobslprh	101	27	treatments	treatment	NNS
cord-017954-vobslprh	101	28	fail	fail	VBP
cord-017954-vobslprh	101	29	when	when	WRB
cord-017954-vobslprh	101	30	they	-PRON-	PRP
cord-017954-vobslprh	101	31	enter	enter	VBP
cord-017954-vobslprh	101	32	MS	MS	NNP
cord-017954-vobslprh	101	33	clinical	clinical	JJ
cord-017954-vobslprh	101	34	trials	trial	NNS
cord-017954-vobslprh	101	35	.	.	.
cord-017954-vobslprh	102	1	An	an	DT
cord-017954-vobslprh	102	2	explanation	explanation	NN
cord-017954-vobslprh	102	3	for	for	IN
cord-017954-vobslprh	102	4	this	this	DT
cord-017954-vobslprh	102	5	might	may	MD
cord-017954-vobslprh	102	6	be	be	VB
cord-017954-vobslprh	102	7	that	that	IN
cord-017954-vobslprh	102	8	treatment	treatment	NN
cord-017954-vobslprh	102	9	studies	study	NNS
cord-017954-vobslprh	102	10	using	use	VBG
cord-017954-vobslprh	102	11	the	the	DT
cord-017954-vobslprh	102	12	EAE	EAE	NNP
cord-017954-vobslprh	102	13	model	model	NN
cord-017954-vobslprh	102	14	do	do	VBP
cord-017954-vobslprh	102	15	not	not	RB
cord-017954-vobslprh	102	16	mimic	mimic	VB
cord-017954-vobslprh	102	17	the	the	DT
cord-017954-vobslprh	102	18	patient	patient	NN
cord-017954-vobslprh	102	19	disease	disease	NN
cord-017954-vobslprh	102	20	course	course	NN
cord-017954-vobslprh	102	21	in	in	IN
cord-017954-vobslprh	102	22	the	the	DT
cord-017954-vobslprh	102	23	clinic	clinic	NN
cord-017954-vobslprh	102	24	.	.	.
cord-017954-vobslprh	103	1	For	for	IN
cord-017954-vobslprh	103	2	example	example	NN
cord-017954-vobslprh	103	3	,	,	,
cord-017954-vobslprh	103	4	the	the	DT
cord-017954-vobslprh	103	5	administration	administration	NN
cord-017954-vobslprh	103	6	of	of	IN
cord-017954-vobslprh	103	7	drugs	drug	NNS
cord-017954-vobslprh	103	8	before	before	IN
cord-017954-vobslprh	103	9	the	the	DT
cord-017954-vobslprh	103	10	initiation	initiation	NN
cord-017954-vobslprh	103	11	of	of	IN
cord-017954-vobslprh	103	12	EAE	EAE	NNP
cord-017954-vobslprh	103	13	disease	disease	NN
cord-017954-vobslprh	103	14	is	be	VBZ
cord-017954-vobslprh	103	15	only	only	RB
cord-017954-vobslprh	103	16	useful	useful	JJ
cord-017954-vobslprh	103	17	for	for	IN
cord-017954-vobslprh	103	18	indicating	indicate	VBG
cord-017954-vobslprh	103	19	an	an	DT
cord-017954-vobslprh	103	20	effect	effect	NN
cord-017954-vobslprh	103	21	on	on	IN
cord-017954-vobslprh	103	22	the	the	DT
cord-017954-vobslprh	103	23	activation	activation	NN
cord-017954-vobslprh	103	24	of	of	IN
cord-017954-vobslprh	103	25	T	T	NNP
cord-017954-vobslprh	103	26	cells	cell	NNS
cord-017954-vobslprh	103	27	and	and	CC
cord-017954-vobslprh	103	28	has	have	VBZ
cord-017954-vobslprh	103	29	no	no	DT
cord-017954-vobslprh	103	30	real	real	JJ
cord-017954-vobslprh	103	31	clinical	clinical	JJ
cord-017954-vobslprh	103	32	significance	significance	NN
cord-017954-vobslprh	103	33	for	for	IN
cord-017954-vobslprh	103	34	MS	MS	NNP
cord-017954-vobslprh	103	35	treatment	treatment	NN
cord-017954-vobslprh	103	36	,	,	,
cord-017954-vobslprh	103	37	where	where	WRB
cord-017954-vobslprh	103	38	patients	patient	NNS
cord-017954-vobslprh	103	39	have	have	VBP
cord-017954-vobslprh	103	40	often	often	RB
cord-017954-vobslprh	103	41	experienced	experience	VBN
cord-017954-vobslprh	103	42	symptoms	symptom	NNS
cord-017954-vobslprh	103	43	for	for	IN
cord-017954-vobslprh	103	44	some	some	DT
cord-017954-vobslprh	103	45	time	time	NN
cord-017954-vobslprh	103	46	before	before	IN
cord-017954-vobslprh	103	47	treatments	treatment	NNS
cord-017954-vobslprh	103	48	are	be	VBP
cord-017954-vobslprh	103	49	started	start	VBN
cord-017954-vobslprh	103	50	.	.	.
cord-017954-vobslprh	104	1	In	in	IN
cord-017954-vobslprh	104	2	addition	addition	NN
cord-017954-vobslprh	104	3	,	,	,
cord-017954-vobslprh	104	4	treatments	treatment	NNS
cord-017954-vobslprh	104	5	administered	administer	VBN
cord-017954-vobslprh	104	6	before	before	IN
cord-017954-vobslprh	104	7	the	the	DT
cord-017954-vobslprh	104	8	onset	onset	NN
cord-017954-vobslprh	104	9	of	of	IN
cord-017954-vobslprh	104	10	symptoms	symptom	NNS
cord-017954-vobslprh	104	11	that	that	WDT
cord-017954-vobslprh	104	12	prevent	prevent	VBP
cord-017954-vobslprh	104	13	paralysis	paralysis	NN
cord-017954-vobslprh	104	14	are	be	VBP
cord-017954-vobslprh	104	15	often	often	RB
cord-017954-vobslprh	104	16	said	say	VBN
cord-017954-vobslprh	104	17	to	to	TO
cord-017954-vobslprh	104	18	prevent	prevent	VB
cord-017954-vobslprh	104	19	demyelination	demyelination	NN
cord-017954-vobslprh	104	20	.	.	.
cord-017954-vobslprh	105	1	However	however	RB
cord-017954-vobslprh	105	2	,	,	,
cord-017954-vobslprh	105	3	if	if	IN
cord-017954-vobslprh	105	4	these	these	DT
cord-017954-vobslprh	105	5	treatments	treatment	NNS
cord-017954-vobslprh	105	6	are	be	VBP
cord-017954-vobslprh	105	7	immunomodulatory	immunomodulatory	JJ
cord-017954-vobslprh	105	8	,	,	,
cord-017954-vobslprh	105	9	then	then	RB
cord-017954-vobslprh	105	10	it	-PRON-	PRP
cord-017954-vobslprh	105	11	is	be	VBZ
cord-017954-vobslprh	105	12	difficult	difficult	JJ
cord-017954-vobslprh	105	13	to	to	TO
cord-017954-vobslprh	105	14	differentiate	differentiate	VB
cord-017954-vobslprh	105	15	between	between	IN
cord-017954-vobslprh	105	16	their	-PRON-	PRP$
cord-017954-vobslprh	105	17	anti	anti	JJ
cord-017954-vobslprh	105	18	-	-	JJ
cord-017954-vobslprh	105	19	demyelination	demyelination	JJ
cord-017954-vobslprh	105	20	and	and	CC
cord-017954-vobslprh	105	21	immunosuppressive	immunosuppressive	JJ
cord-017954-vobslprh	105	22	effects	effect	NNS
cord-017954-vobslprh	105	23	.	.	.
cord-017954-vobslprh	106	1	Therefore	therefore	RB
cord-017954-vobslprh	106	2	,	,	,
cord-017954-vobslprh	106	3	potential	potential	JJ
cord-017954-vobslprh	106	4	treatments	treatment	NNS
cord-017954-vobslprh	106	5	should	should	MD
cord-017954-vobslprh	106	6	be	be	VB
cord-017954-vobslprh	106	7	administered	administer	VBN
cord-017954-vobslprh	106	8	after	after	IN
cord-017954-vobslprh	106	9	the	the	DT
cord-017954-vobslprh	106	10	onset	onset	NN
cord-017954-vobslprh	106	11	of	of	IN
cord-017954-vobslprh	106	12	EAE	EAE	NNP
cord-017954-vobslprh	106	13	symptoms	symptom	NNS
cord-017954-vobslprh	106	14	for	for	IN
cord-017954-vobslprh	106	15	clinically	clinically	RB
cord-017954-vobslprh	106	16	meaningful	meaningful	JJ
cord-017954-vobslprh	106	17	results	result	NNS
cord-017954-vobslprh	106	18	.	.	.
cord-017954-vobslprh	107	1	In	in	IN
cord-017954-vobslprh	107	2	summary	summary	NN
cord-017954-vobslprh	107	3	,	,	,
cord-017954-vobslprh	107	4	although	although	IN
cord-017954-vobslprh	107	5	EAE	EAE	NNP
cord-017954-vobslprh	107	6	is	be	VBZ
cord-017954-vobslprh	107	7	an	an	DT
cord-017954-vobslprh	107	8	imperfect	imperfect	JJ
cord-017954-vobslprh	107	9	model	model	NN
cord-017954-vobslprh	107	10	of	of	IN
cord-017954-vobslprh	107	11	MS	MS	NNP
cord-017954-vobslprh	107	12	,	,	,
cord-017954-vobslprh	107	13	its	-PRON-	PRP$
cord-017954-vobslprh	107	14	correct	correct	JJ
cord-017954-vobslprh	107	15	usage	usage	NN
cord-017954-vobslprh	107	16	by	by	IN
cord-017954-vobslprh	107	17	investigators	investigator	NNS
cord-017954-vobslprh	107	18	is	be	VBZ
cord-017954-vobslprh	107	19	critical	critical	JJ
cord-017954-vobslprh	107	20	when	when	WRB
cord-017954-vobslprh	107	21	studying	study	VBG
cord-017954-vobslprh	107	22	novel	novel	JJ
cord-017954-vobslprh	107	23	therapeutic	therapeutic	JJ
cord-017954-vobslprh	107	24	compounds	compound	NNS
cord-017954-vobslprh	107	25	.	.	.
cord-017954-vobslprh	108	1	A	a	DT
cord-017954-vobslprh	108	2	number	number	NN
cord-017954-vobslprh	108	3	of	of	IN
cord-017954-vobslprh	108	4	etiological	etiological	JJ
cord-017954-vobslprh	108	5	studies	study	NNS
cord-017954-vobslprh	108	6	have	have	VBP
cord-017954-vobslprh	108	7	indicated	indicate	VBN
cord-017954-vobslprh	108	8	the	the	DT
cord-017954-vobslprh	108	9	potential	potential	JJ
cord-017954-vobslprh	108	10	role	role	NN
cord-017954-vobslprh	108	11	of	of	IN
cord-017954-vobslprh	108	12	viruses	virus	NNS
cord-017954-vobslprh	108	13	in	in	IN
cord-017954-vobslprh	108	14	the	the	DT
cord-017954-vobslprh	108	15	susceptibility	susceptibility	NN
cord-017954-vobslprh	108	16	,	,	,
cord-017954-vobslprh	108	17	onset	onset	NN
cord-017954-vobslprh	108	18	,	,	,
cord-017954-vobslprh	108	19	and	and	CC
cord-017954-vobslprh	108	20	exacerbation	exacerbation	NN
cord-017954-vobslprh	108	21	of	of	IN
cord-017954-vobslprh	108	22	MS	MS	NNP
cord-017954-vobslprh	108	23	.	.	.
cord-017954-vobslprh	109	1	Therefore	therefore	RB
cord-017954-vobslprh	109	2	,	,	,
cord-017954-vobslprh	109	3	in	in	IN
cord-017954-vobslprh	109	4	addition	addition	NN
cord-017954-vobslprh	109	5	to	to	IN
cord-017954-vobslprh	109	6	immunization	immunization	NN
cord-017954-vobslprh	109	7	models	model	NNS
cord-017954-vobslprh	109	8	that	that	WDT
cord-017954-vobslprh	109	9	are	be	VBP
cord-017954-vobslprh	109	10	useful	useful	JJ
cord-017954-vobslprh	109	11	to	to	TO
cord-017954-vobslprh	109	12	investigate	investigate	VB
cord-017954-vobslprh	109	13	the	the	DT
cord-017954-vobslprh	109	14	early	early	JJ
cord-017954-vobslprh	109	15	immunological	immunological	JJ
cord-017954-vobslprh	109	16	pathways	pathway	NNS
cord-017954-vobslprh	109	17	involved	involve	VBN
cord-017954-vobslprh	109	18	in	in	IN
cord-017954-vobslprh	109	19	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	109	20	,	,	,
cord-017954-vobslprh	109	21	a	a	DT
cord-017954-vobslprh	109	22	number	number	NN
cord-017954-vobslprh	109	23	of	of	IN
cord-017954-vobslprh	109	24	virus	virus	NN
cord-017954-vobslprh	109	25	-	-	HYPH
cord-017954-vobslprh	109	26	induced	induce	VBN
cord-017954-vobslprh	109	27	demyelinating	demyelinating	NN
cord-017954-vobslprh	109	28	models	model	NNS
cord-017954-vobslprh	109	29	have	have	VBP
cord-017954-vobslprh	109	30	been	be	VBN
cord-017954-vobslprh	109	31	developed	develop	VBN
cord-017954-vobslprh	109	32	that	that	WDT
cord-017954-vobslprh	109	33	allow	allow	VB
cord-017954-vobslprh	109	34	the	the	DT
cord-017954-vobslprh	109	35	study	study	NN
cord-017954-vobslprh	109	36	of	of	IN
cord-017954-vobslprh	109	37	the	the	DT
cord-017954-vobslprh	109	38	potential	potential	JJ
cord-017954-vobslprh	109	39	viral	viral	JJ
cord-017954-vobslprh	109	40	aetiology	aetiology	NN
cord-017954-vobslprh	109	41	of	of	IN
cord-017954-vobslprh	109	42	MS	MS	NNP
cord-017954-vobslprh	109	43	.	.	.
cord-017954-vobslprh	110	1	Using	use	VBG
cord-017954-vobslprh	110	2	these	these	DT
cord-017954-vobslprh	110	3	models	model	NNS
cord-017954-vobslprh	110	4	a	a	DT
cord-017954-vobslprh	110	5	number	number	NN
cord-017954-vobslprh	110	6	of	of	IN
cord-017954-vobslprh	110	7	hypotheses	hypothesis	NNS
cord-017954-vobslprh	110	8	of	of	IN
cord-017954-vobslprh	110	9	the	the	DT
cord-017954-vobslprh	110	10	mechanism	mechanism	NN
cord-017954-vobslprh	110	11	of	of	IN
cord-017954-vobslprh	110	12	disease	disease	NN
cord-017954-vobslprh	110	13	onset	onset	NN
cord-017954-vobslprh	110	14	have	have	VBP
cord-017954-vobslprh	110	15	been	be	VBN
cord-017954-vobslprh	110	16	developed	develop	VBN
cord-017954-vobslprh	110	17	including	include	VBG
cord-017954-vobslprh	110	18	molecular	molecular	JJ
cord-017954-vobslprh	110	19	mimicry	mimicry	NN
cord-017954-vobslprh	110	20	,	,	,
cord-017954-vobslprh	110	21	epitope	epitope	NN
cord-017954-vobslprh	110	22	spreading	spread	VBG
cord-017954-vobslprh	110	23	,	,	,
cord-017954-vobslprh	110	24	direct	direct	JJ
cord-017954-vobslprh	110	25	bystander	bystander	NN
cord-017954-vobslprh	110	26	activation	activation	NN
cord-017954-vobslprh	110	27	,	,	,
cord-017954-vobslprh	110	28	and	and	CC
cord-017954-vobslprh	110	29	release	release	NN
cord-017954-vobslprh	110	30	of	of	IN
cord-017954-vobslprh	110	31	cryptic	cryptic	JJ
cord-017954-vobslprh	110	32	epitopes	epitope	NNS
cord-017954-vobslprh	110	33	.	.	.
cord-017954-vobslprh	111	1	Theiler	Theiler	NNP
cord-017954-vobslprh	111	2	's	's	POS
cord-017954-vobslprh	111	3	murine	murine	JJ
cord-017954-vobslprh	111	4	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	111	5	(	(	-LRB-
cord-017954-vobslprh	111	6	TMEV	TMEV	NNP
cord-017954-vobslprh	111	7	)	)	-RRB-
cord-017954-vobslprh	111	8	is	be	VBZ
cord-017954-vobslprh	111	9	a	a	DT
cord-017954-vobslprh	111	10	single	single	JJ
cord-017954-vobslprh	111	11	-	-	HYPH
cord-017954-vobslprh	111	12	strand	strand	NN
cord-017954-vobslprh	111	13	RNA	RNA	NNP
cord-017954-vobslprh	111	14	virus	virus	NN
cord-017954-vobslprh	111	15	that	that	WDT
cord-017954-vobslprh	111	16	belongs	belong	VBZ
cord-017954-vobslprh	111	17	to	to	IN
cord-017954-vobslprh	111	18	the	the	DT
cord-017954-vobslprh	111	19	cardiovirus	cardiovirus	NNP
cord-017954-vobslprh	111	20	group	group	NN
cord-017954-vobslprh	111	21	of	of	IN
cord-017954-vobslprh	111	22	the	the	DT
cord-017954-vobslprh	111	23	Picornaviridae	Picornaviridae	NNP
cord-017954-vobslprh	111	24	and	and	CC
cord-017954-vobslprh	111	25	is	be	VBZ
cord-017954-vobslprh	111	26	a	a	DT
cord-017954-vobslprh	111	27	natural	natural	JJ
cord-017954-vobslprh	111	28	mouse	mouse	NN
cord-017954-vobslprh	111	29	pathogen	pathogen	NN
cord-017954-vobslprh	111	30	.	.	.
cord-017954-vobslprh	112	1	TMEV	TMEV	NNP
cord-017954-vobslprh	112	2	-	-	HYPH
cord-017954-vobslprh	112	3	induced	induce	VBN
cord-017954-vobslprh	112	4	demyelinating	demyelinate	VBG
cord-017954-vobslprh	112	5	disease	disease	NN
cord-017954-vobslprh	112	6	(	(	-LRB-
cord-017954-vobslprh	112	7	TMEV	TMEV	NNP
cord-017954-vobslprh	112	8	-	-	HYPH
cord-017954-vobslprh	112	9	IDD	IDD	NNP
cord-017954-vobslprh	112	10	)	)	-RRB-
cord-017954-vobslprh	112	11	develops	develop	VBZ
cord-017954-vobslprh	112	12	in	in	IN
cord-017954-vobslprh	112	13	susceptible	susceptible	JJ
cord-017954-vobslprh	112	14	strains	strain	NNS
cord-017954-vobslprh	112	15	of	of	IN
cord-017954-vobslprh	112	16	mice	mouse	NNS
cord-017954-vobslprh	112	17	(	(	-LRB-
cord-017954-vobslprh	112	18	SJL	SJL	NNP
cord-017954-vobslprh	112	19	/	/	SYM
cord-017954-vobslprh	112	20	J	J	NNP
cord-017954-vobslprh	112	21	)	)	-RRB-
cord-017954-vobslprh	112	22	upon	upon	IN
cord-017954-vobslprh	112	23	intracranial	intracranial	JJ
cord-017954-vobslprh	112	24	injection	injection	NN
cord-017954-vobslprh	112	25	of	of	IN
cord-017954-vobslprh	112	26	the	the	DT
cord-017954-vobslprh	112	27	BeAn	BeAn	NNP
cord-017954-vobslprh	112	28	8386	8386	CD
cord-017954-vobslprh	112	29	strain	strain	NN
cord-017954-vobslprh	112	30	of	of	IN
cord-017954-vobslprh	112	31	TMEV	TMEV	NNP
cord-017954-vobslprh	112	32	,	,	,
cord-017954-vobslprh	112	33	which	which	WDT
cord-017954-vobslprh	112	34	persistently	persistently	RB
cord-017954-vobslprh	112	35	infect	infect	VBP
cord-017954-vobslprh	112	36	microglial	microglial	JJ
cord-017954-vobslprh	112	37	cell	cell	NN
cord-017954-vobslprh	112	38	populations	population	NNS
cord-017954-vobslprh	112	39	in	in	IN
cord-017954-vobslprh	112	40	the	the	DT
cord-017954-vobslprh	112	41	CNS	CNS	NNP
cord-017954-vobslprh	112	42	[	[	-LRB-
cord-017954-vobslprh	112	43	34	34	CD
cord-017954-vobslprh	112	44	,	,	,
cord-017954-vobslprh	112	45	35	35	CD
cord-017954-vobslprh	112	46	]	]	-RRB-
cord-017954-vobslprh	112	47	.	.	.
cord-017954-vobslprh	113	1	The	the	DT
cord-017954-vobslprh	113	2	persistent	persistent	JJ
cord-017954-vobslprh	113	3	infection	infection	NN
cord-017954-vobslprh	113	4	of	of	IN
cord-017954-vobslprh	113	5	TMEV	TMEV	NNP
cord-017954-vobslprh	113	6	is	be	VBZ
cord-017954-vobslprh	113	7	thought	think	VBN
cord-017954-vobslprh	113	8	to	to	TO
cord-017954-vobslprh	113	9	cause	cause	VB
cord-017954-vobslprh	113	10	demyelination	demyelination	NN
cord-017954-vobslprh	113	11	mediated	mediate	VBN
cord-017954-vobslprh	113	12	by	by	IN
cord-017954-vobslprh	113	13	macrophage	macrophage	NN
cord-017954-vobslprh	113	14	bystander	bystander	NN
cord-017954-vobslprh	113	15	destruction	destruction	NN
cord-017954-vobslprh	113	16	activated	activate	VBN
cord-017954-vobslprh	113	17	by	by	IN
cord-017954-vobslprh	113	18	TMEV	TMEV	NNP
cord-017954-vobslprh	113	19	-	-	HYPH
cord-017954-vobslprh	113	20	specific	specific	JJ
cord-017954-vobslprh	113	21	CD4þ	CD4þ	NNP
cord-017954-vobslprh	113	22	T	t	NN
cord-017954-vobslprh	113	23	-	-	HYPH
cord-017954-vobslprh	113	24	cell	cell	NN
cord-017954-vobslprh	113	25	responses	response	NNS
cord-017954-vobslprh	113	26	that	that	WDT
cord-017954-vobslprh	113	27	target	target	VBP
cord-017954-vobslprh	113	28	the	the	DT
cord-017954-vobslprh	113	29	persistent	persistent	JJ
cord-017954-vobslprh	113	30	viral	viral	JJ
cord-017954-vobslprh	113	31	infection	infection	NN
cord-017954-vobslprh	113	32	,	,	,
cord-017954-vobslprh	113	33	leading	lead	VBG
cord-017954-vobslprh	113	34	to	to	IN
cord-017954-vobslprh	113	35	the	the	DT
cord-017954-vobslprh	113	36	release	release	NN
cord-017954-vobslprh	113	37	of	of	IN
cord-017954-vobslprh	113	38	myelin	myelin	JJ
cord-017954-vobslprh	113	39	antigens	antigen	NNS
cord-017954-vobslprh	113	40	that	that	WDT
cord-017954-vobslprh	113	41	can	can	MD
cord-017954-vobslprh	113	42	activate	activate	VB
cord-017954-vobslprh	113	43	autoreactive	autoreactive	JJ
cord-017954-vobslprh	113	44	PLP156	PLP156	NNP
cord-017954-vobslprh	113	45	-	-	HYPH
cord-017954-vobslprh	113	46	171-specific	171-specific	CD
cord-017954-vobslprh	113	47	T	t	NN
cord-017954-vobslprh	113	48	cells	cell	NNS
cord-017954-vobslprh	113	49	that	that	WDT
cord-017954-vobslprh	113	50	have	have	VBP
cord-017954-vobslprh	113	51	escaped	escape	VBN
cord-017954-vobslprh	113	52	negative	negative	JJ
cord-017954-vobslprh	113	53	selection	selection	NN
cord-017954-vobslprh	113	54	[	[	-LRB-
cord-017954-vobslprh	113	55	36	36	CD
cord-017954-vobslprh	113	56	]	]	-RRB-
cord-017954-vobslprh	113	57	.	.	.
cord-017954-vobslprh	114	1	Epitope	epitope	NN
cord-017954-vobslprh	114	2	spreading	spread	VBG
cord-017954-vobslprh	114	3	to	to	IN
cord-017954-vobslprh	114	4	other	other	JJ
cord-017954-vobslprh	114	5	myelin	myelin	JJ
cord-017954-vobslprh	114	6	epitopes	epitope	NNS
cord-017954-vobslprh	114	7	propagates	propagate	VBZ
cord-017954-vobslprh	114	8	the	the	DT
cord-017954-vobslprh	114	9	disease	disease	NN
cord-017954-vobslprh	114	10	,	,	,
cord-017954-vobslprh	114	11	which	which	WDT
cord-017954-vobslprh	114	12	shows	show	VBZ
cord-017954-vobslprh	114	13	similar	similar	JJ
cord-017954-vobslprh	114	14	inflammatory	inflammatory	JJ
cord-017954-vobslprh	114	15	and	and	CC
cord-017954-vobslprh	114	16	demyelinating	demyelinating	JJ
cord-017954-vobslprh	114	17	pathological	pathological	JJ
cord-017954-vobslprh	114	18	hallmarks	hallmark	NNS
cord-017954-vobslprh	114	19	as	as	IN
cord-017954-vobslprh	114	20	those	those	DT
cord-017954-vobslprh	114	21	seen	see	VBN
cord-017954-vobslprh	114	22	in	in	IN
cord-017954-vobslprh	114	23	MS	MS	NNP
cord-017954-vobslprh	114	24	patients	patient	NNS
cord-017954-vobslprh	114	25	[	[	-LRB-
cord-017954-vobslprh	114	26	37	37	CD
cord-017954-vobslprh	114	27	,	,	,
cord-017954-vobslprh	114	28	38	38	CD
cord-017954-vobslprh	114	29	]	]	-RRB-
cord-017954-vobslprh	114	30	.	.	.
cord-017954-vobslprh	115	1	The	the	DT
cord-017954-vobslprh	115	2	onset	onset	NN
cord-017954-vobslprh	115	3	of	of	IN
cord-017954-vobslprh	115	4	a	a	DT
cord-017954-vobslprh	115	5	chronic	chronic	JJ
cord-017954-vobslprh	115	6	progressive	progressive	JJ
cord-017954-vobslprh	115	7	demyelinating	demyelinate	VBG
cord-017954-vobslprh	115	8	disease	disease	NN
cord-017954-vobslprh	115	9	with	with	IN
cord-017954-vobslprh	115	10	no	no	DT
cord-017954-vobslprh	115	11	recovery	recovery	NN
cord-017954-vobslprh	115	12	or	or	CC
cord-017954-vobslprh	115	13	remission	remission	NN
cord-017954-vobslprh	115	14	periods	period	NNS
cord-017954-vobslprh	115	15	occurs	occur	VBZ
cord-017954-vobslprh	115	16	around	around	IN
cord-017954-vobslprh	115	17	day	day	NN
cord-017954-vobslprh	115	18	30	30	CD
cord-017954-vobslprh	115	19	-	-	SYM
cord-017954-vobslprh	115	20	35	35	CD
cord-017954-vobslprh	115	21	post	post	NN
cord-017954-vobslprh	115	22	-	-	NN
cord-017954-vobslprh	115	23	infection	infection	NN
cord-017954-vobslprh	115	24	and	and	CC
cord-017954-vobslprh	115	25	continues	continue	VBZ
cord-017954-vobslprh	115	26	for	for	IN
cord-017954-vobslprh	115	27	over	over	IN
cord-017954-vobslprh	115	28	100	100	CD
cord-017954-vobslprh	115	29	days	day	NNS
cord-017954-vobslprh	115	30	.	.	.
cord-017954-vobslprh	116	1	TMEV	TMEV	NNP
cord-017954-vobslprh	116	2	-	-	HYPH
cord-017954-vobslprh	116	3	IDD	IDD	NNP
cord-017954-vobslprh	116	4	is	be	VBZ
cord-017954-vobslprh	116	5	characterized	characterize	VBN
cord-017954-vobslprh	116	6	by	by	IN
cord-017954-vobslprh	116	7	the	the	DT
cord-017954-vobslprh	116	8	development	development	NN
cord-017954-vobslprh	116	9	of	of	IN
cord-017954-vobslprh	116	10	a	a	DT
cord-017954-vobslprh	116	11	spastic	spastic	JJ
cord-017954-vobslprh	116	12	hind	hind	JJ
cord-017954-vobslprh	116	13	-	-	HYPH
cord-017954-vobslprh	116	14	limb	limb	NN
cord-017954-vobslprh	116	15	paralysis	paralysis	NN
cord-017954-vobslprh	116	16	and	and	CC
cord-017954-vobslprh	116	17	perivascular	perivascular	JJ
cord-017954-vobslprh	116	18	and	and	CC
cord-017954-vobslprh	116	19	parenchymal	parenchymal	JJ
cord-017954-vobslprh	116	20	lesions	lesion	NNS
cord-017954-vobslprh	116	21	in	in	IN
cord-017954-vobslprh	116	22	the	the	DT
cord-017954-vobslprh	116	23	spinal	spinal	JJ
cord-017954-vobslprh	116	24	cord	cord	NN
cord-017954-vobslprh	116	25	with	with	IN
cord-017954-vobslprh	116	26	demyelination	demyelination	NN
cord-017954-vobslprh	116	27	of	of	IN
cord-017954-vobslprh	116	28	white	white	JJ
cord-017954-vobslprh	116	29	matter	matter	NN
cord-017954-vobslprh	116	30	tracts	tract	NNS
cord-017954-vobslprh	116	31	containing	contain	VBG
cord-017954-vobslprh	116	32	mononuclear	mononuclear	JJ
cord-017954-vobslprh	116	33	cell	cell	NN
cord-017954-vobslprh	116	34	infiltrates	infiltrate	VBZ
cord-017954-vobslprh	116	35	.	.	.
cord-017954-vobslprh	117	1	Although	although	IN
cord-017954-vobslprh	117	2	epitope	epitope	NN
cord-017954-vobslprh	117	3	spreading	spreading	NN
cord-017954-vobslprh	117	4	is	be	VBZ
cord-017954-vobslprh	117	5	thought	think	VBN
cord-017954-vobslprh	117	6	to	to	TO
cord-017954-vobslprh	117	7	be	be	VB
cord-017954-vobslprh	117	8	involved	involve	VBN
cord-017954-vobslprh	117	9	in	in	IN
cord-017954-vobslprh	117	10	TMEV	TMEV	NNP
cord-017954-vobslprh	117	11	-	-	HYPH
cord-017954-vobslprh	117	12	IDD	IDD	NNP
cord-017954-vobslprh	117	13	,	,	,
cord-017954-vobslprh	117	14	molecular	molecular	JJ
cord-017954-vobslprh	117	15	mimicry	mimicry	NN
cord-017954-vobslprh	117	16	,	,	,
cord-017954-vobslprh	117	17	the	the	DT
cord-017954-vobslprh	117	18	mistaken	mistaken	JJ
cord-017954-vobslprh	117	19	recognition	recognition	NN
cord-017954-vobslprh	117	20	of	of	IN
cord-017954-vobslprh	117	21	a	a	DT
cord-017954-vobslprh	117	22	pathogenic	pathogenic	JJ
cord-017954-vobslprh	117	23	epitope	epitope	NN
cord-017954-vobslprh	117	24	for	for	IN
cord-017954-vobslprh	117	25	a	a	DT
cord-017954-vobslprh	117	26	"	"	``
cord-017954-vobslprh	117	27	self	self	NN
cord-017954-vobslprh	117	28	"	"	''
cord-017954-vobslprh	117	29	epitope	epitope	NN
cord-017954-vobslprh	117	30	due	due	JJ
cord-017954-vobslprh	117	31	to	to	IN
cord-017954-vobslprh	117	32	shared	share	VBN
cord-017954-vobslprh	117	33	amino	amino	NN
cord-017954-vobslprh	117	34	acid	acid	NN
cord-017954-vobslprh	117	35	sequences	sequence	NNS
cord-017954-vobslprh	117	36	,	,	,
cord-017954-vobslprh	117	37	is	be	VBZ
cord-017954-vobslprh	117	38	another	another	DT
cord-017954-vobslprh	117	39	potential	potential	JJ
cord-017954-vobslprh	117	40	mechanism	mechanism	NN
cord-017954-vobslprh	117	41	for	for	IN
cord-017954-vobslprh	117	42	the	the	DT
cord-017954-vobslprh	117	43	induction	induction	NN
cord-017954-vobslprh	117	44	of	of	IN
cord-017954-vobslprh	117	45	autoimmunity	autoimmunity	NN
cord-017954-vobslprh	117	46	.	.	.
cord-017954-vobslprh	118	1	Early	early	JJ
cord-017954-vobslprh	118	2	studies	study	NNS
cord-017954-vobslprh	118	3	demonstrated	demonstrate	VBD
cord-017954-vobslprh	118	4	that	that	IN
cord-017954-vobslprh	118	5	the	the	DT
cord-017954-vobslprh	118	6	immunization	immunization	NN
cord-017954-vobslprh	118	7	of	of	IN
cord-017954-vobslprh	118	8	viral	viral	JJ
cord-017954-vobslprh	118	9	peptides	peptide	NNS
cord-017954-vobslprh	118	10	could	could	MD
cord-017954-vobslprh	118	11	stimulate	stimulate	VB
cord-017954-vobslprh	118	12	myelin	myelin	JJ
cord-017954-vobslprh	118	13	peptide	peptide	NN
cord-017954-vobslprh	118	14	-	-	HYPH
cord-017954-vobslprh	118	15	specific	specific	JJ
cord-017954-vobslprh	118	16	T	t	NN
cord-017954-vobslprh	118	17	-	-	HYPH
cord-017954-vobslprh	118	18	cell	cell	NN
cord-017954-vobslprh	118	19	responses	response	NNS
cord-017954-vobslprh	118	20	in	in	IN
cord-017954-vobslprh	118	21	vivo	vivo	NNP
cord-017954-vobslprh	118	22	[	[	-LRB-
cord-017954-vobslprh	118	23	39	39	CD
cord-017954-vobslprh	118	24	,	,	,
cord-017954-vobslprh	118	25	40	40	CD
cord-017954-vobslprh	118	26	]	]	-RRB-
cord-017954-vobslprh	118	27	.	.	.
cord-017954-vobslprh	119	1	However	however	RB
cord-017954-vobslprh	119	2	,	,	,
cord-017954-vobslprh	119	3	the	the	DT
cord-017954-vobslprh	119	4	need	need	NN
cord-017954-vobslprh	119	5	for	for	IN
cord-017954-vobslprh	119	6	epitope	epitope	NN
cord-017954-vobslprh	119	7	processing	processing	NN
cord-017954-vobslprh	119	8	and	and	CC
cord-017954-vobslprh	119	9	the	the	DT
cord-017954-vobslprh	119	10	role	role	NN
cord-017954-vobslprh	119	11	of	of	IN
cord-017954-vobslprh	119	12	a	a	DT
cord-017954-vobslprh	119	13	"	"	``
cord-017954-vobslprh	119	14	live	live	JJ
cord-017954-vobslprh	119	15	"	"	''
cord-017954-vobslprh	119	16	viral	viral	JJ
cord-017954-vobslprh	119	17	infection	infection	NN
cord-017954-vobslprh	119	18	to	to	TO
cord-017954-vobslprh	119	19	stimulate	stimulate	VB
cord-017954-vobslprh	119	20	the	the	DT
cord-017954-vobslprh	119	21	host	host	NN
cord-017954-vobslprh	119	22	innate	innate	JJ
cord-017954-vobslprh	119	23	immune	immune	JJ
cord-017954-vobslprh	119	24	system	system	NN
cord-017954-vobslprh	119	25	are	be	VBP
cord-017954-vobslprh	119	26	not	not	RB
cord-017954-vobslprh	119	27	addressed	address	VBN
cord-017954-vobslprh	119	28	by	by	IN
cord-017954-vobslprh	119	29	short	short	JJ
cord-017954-vobslprh	119	30	-	-	HYPH
cord-017954-vobslprh	119	31	length	length	NN
cord-017954-vobslprh	119	32	peptide	peptide	NN
cord-017954-vobslprh	119	33	immunization	immunization	NN
cord-017954-vobslprh	119	34	.	.	.
cord-017954-vobslprh	120	1	Therefore	therefore	RB
cord-017954-vobslprh	120	2	,	,	,
cord-017954-vobslprh	120	3	recombinant	recombinant	JJ
cord-017954-vobslprh	120	4	TMEV	TMEV	NNP
cord-017954-vobslprh	120	5	strains	strain	NNS
cord-017954-vobslprh	120	6	engineered	engineer	VBN
cord-017954-vobslprh	120	7	to	to	TO
cord-017954-vobslprh	120	8	incorporate	incorporate	VB
cord-017954-vobslprh	120	9	30-mer	30-mer	CD
cord-017954-vobslprh	120	10	myelin	myelin	NN
cord-017954-vobslprh	120	11	or	or	CC
cord-017954-vobslprh	120	12	bacterial	bacterial	JJ
cord-017954-vobslprh	120	13	/	/	SYM
cord-017954-vobslprh	120	14	viral	viral	JJ
cord-017954-vobslprh	120	15	myelin	myelin	NN
cord-017954-vobslprh	120	16	mimic	mimic	VBP
cord-017954-vobslprh	120	17	epitopes	epitope	NNS
cord-017954-vobslprh	120	18	were	be	VBD
cord-017954-vobslprh	120	19	used	use	VBN
cord-017954-vobslprh	120	20	to	to	TO
cord-017954-vobslprh	120	21	study	study	VB
cord-017954-vobslprh	120	22	the	the	DT
cord-017954-vobslprh	120	23	potential	potential	JJ
cord-017954-vobslprh	120	24	viral	viral	JJ
cord-017954-vobslprh	120	25	induction	induction	NN
cord-017954-vobslprh	120	26	of	of	IN
cord-017954-vobslprh	120	27	autoimmunity	autoimmunity	NN
cord-017954-vobslprh	120	28	by	by	IN
cord-017954-vobslprh	120	29	molecular	molecular	JJ
cord-017954-vobslprh	120	30	mimicry	mimicry	NN
cord-017954-vobslprh	120	31	[	[	-LRB-
cord-017954-vobslprh	120	32	41	41	CD
cord-017954-vobslprh	120	33	,	,	,
cord-017954-vobslprh	120	34	42	42	CD
cord-017954-vobslprh	120	35	]	]	-RRB-
cord-017954-vobslprh	120	36	.	.	.
cord-017954-vobslprh	121	1	Infection	infection	NN
cord-017954-vobslprh	121	2	of	of	IN
cord-017954-vobslprh	121	3	SJL	SJL	NNP
cord-017954-vobslprh	121	4	mice	mouse	NNS
cord-017954-vobslprh	121	5	with	with	IN
cord-017954-vobslprh	121	6	TMEV	TMEV	NNP
cord-017954-vobslprh	121	7	engineered	engineer	VBN
cord-017954-vobslprh	121	8	to	to	TO
cord-017954-vobslprh	121	9	express	express	VB
cord-017954-vobslprh	121	10	a	a	DT
cord-017954-vobslprh	121	11	PLP	PLP	NNP
cord-017954-vobslprh	121	12	mimic	mimic	VB
cord-017954-vobslprh	121	13	peptide	peptide	NN
cord-017954-vobslprh	121	14	derived	derive	VBN
cord-017954-vobslprh	121	15	from	from	IN
cord-017954-vobslprh	121	16	Haemophilus	Haemophilus	NNP
cord-017954-vobslprh	121	17	influenzae	influenzae	NN
cord-017954-vobslprh	121	18	,	,	,
cord-017954-vobslprh	121	19	a	a	DT
cord-017954-vobslprh	121	20	natural	natural	JJ
cord-017954-vobslprh	121	21	mouse	mouse	NN
cord-017954-vobslprh	121	22	pathogen	pathogen	NN
cord-017954-vobslprh	121	23	,	,	,
cord-017954-vobslprh	121	24	with	with	IN
cord-017954-vobslprh	121	25	6/13	6/13	CD
cord-017954-vobslprh	121	26	homologous	homologous	JJ
cord-017954-vobslprh	121	27	amino	amino	NN
cord-017954-vobslprh	121	28	acids	acid	NNS
cord-017954-vobslprh	121	29	to	to	IN
cord-017954-vobslprh	121	30	PLP139	PLP139	NNP
cord-017954-vobslprh	121	31	-	-	HYPH
cord-017954-vobslprh	121	32	151	151	CD
cord-017954-vobslprh	121	33	,	,	,
cord-017954-vobslprh	121	34	including	include	VBG
cord-017954-vobslprh	121	35	primary	primary	JJ
cord-017954-vobslprh	121	36	TCR	TCR	NNP
cord-017954-vobslprh	121	37	and	and	CC
cord-017954-vobslprh	121	38	MHC	MHC	NNP
cord-017954-vobslprh	121	39	class	class	NN
cord-017954-vobslprh	121	40	II	II	NNP
cord-017954-vobslprh	121	41	contact	contact	NN
cord-017954-vobslprh	121	42	residues	residue	NNS
cord-017954-vobslprh	121	43	,	,	,
cord-017954-vobslprh	121	44	induced	induce	VBD
cord-017954-vobslprh	121	45	a	a	DT
cord-017954-vobslprh	121	46	mild	mild	JJ
cord-017954-vobslprh	121	47	but	but	CC
cord-017954-vobslprh	121	48	rapid	rapid	JJ
cord-017954-vobslprh	121	49	onset	onset	NN
cord-017954-vobslprh	121	50	CNS	CNS	NNP
cord-017954-vobslprh	121	51	disease	disease	NN
cord-017954-vobslprh	121	52	[	[	-LRB-
cord-017954-vobslprh	121	53	42	42	CD
cord-017954-vobslprh	121	54	]	]	-RRB-
cord-017954-vobslprh	121	55	.	.	.
cord-017954-vobslprh	122	1	Interestingly	interestingly	RB
cord-017954-vobslprh	122	2	,	,	,
cord-017954-vobslprh	122	3	the	the	DT
cord-017954-vobslprh	122	4	immunization	immunization	NN
cord-017954-vobslprh	122	5	of	of	IN
cord-017954-vobslprh	122	6	mice	mouse	NNS
cord-017954-vobslprh	122	7	with	with	IN
cord-017954-vobslprh	122	8	the	the	DT
cord-017954-vobslprh	122	9	Haemophilus	Haemophilus	NNP
cord-017954-vobslprh	122	10	influenzae	influenzae	NN
cord-017954-vobslprh	122	11	peptide	peptide	JJ
cord-017954-vobslprh	122	12	in	in	IN
cord-017954-vobslprh	122	13	complete	complete	JJ
cord-017954-vobslprh	122	14	Freund	Freund	NNP
cord-017954-vobslprh	122	15	's	's	POS
cord-017954-vobslprh	122	16	adjuvant	adjuvant	NN
cord-017954-vobslprh	122	17	failed	fail	VBD
cord-017954-vobslprh	122	18	to	to	TO
cord-017954-vobslprh	122	19	induce	induce	VB
cord-017954-vobslprh	122	20	overt	overt	JJ
cord-017954-vobslprh	122	21	disease	disease	NN
cord-017954-vobslprh	122	22	,	,	,
cord-017954-vobslprh	122	23	indicating	indicate	VBG
cord-017954-vobslprh	122	24	the	the	DT
cord-017954-vobslprh	122	25	importance	importance	NN
cord-017954-vobslprh	122	26	of	of	IN
cord-017954-vobslprh	122	27	pathogen	pathogen	NN
cord-017954-vobslprh	122	28	-	-	HYPH
cord-017954-vobslprh	122	29	delivered	deliver	VBN
cord-017954-vobslprh	122	30	innate	innate	JJ
cord-017954-vobslprh	122	31	immune	immune	JJ
cord-017954-vobslprh	122	32	signals	signal	NNS
cord-017954-vobslprh	122	33	for	for	IN
cord-017954-vobslprh	122	34	the	the	DT
cord-017954-vobslprh	122	35	induction	induction	NN
cord-017954-vobslprh	122	36	of	of	IN
cord-017954-vobslprh	122	37	disease	disease	NN
cord-017954-vobslprh	122	38	by	by	IN
cord-017954-vobslprh	122	39	molecular	molecular	JJ
cord-017954-vobslprh	122	40	mimicry	mimicry	NN
cord-017954-vobslprh	122	41	.	.	.
cord-017954-vobslprh	123	1	Of	of	IN
cord-017954-vobslprh	123	2	note	note	VB
cord-017954-vobslprh	123	3	,	,	,
cord-017954-vobslprh	123	4	viral	viral	JJ
cord-017954-vobslprh	123	5	peptide	peptide	NN
cord-017954-vobslprh	123	6	sequences	sequence	NNS
cord-017954-vobslprh	123	7	in	in	IN
cord-017954-vobslprh	123	8	TMEV	TMEV	NNP
cord-017954-vobslprh	123	9	do	do	VBP
cord-017954-vobslprh	123	10	not	not	RB
cord-017954-vobslprh	123	11	share	share	VB
cord-017954-vobslprh	123	12	any	any	DT
cord-017954-vobslprh	123	13	sequence	sequence	NN
cord-017954-vobslprh	123	14	homology	homology	NN
cord-017954-vobslprh	123	15	with	with	IN
cord-017954-vobslprh	123	16	PLP	PLP	NNP
cord-017954-vobslprh	123	17	,	,	,
cord-017954-vobslprh	123	18	the	the	DT
cord-017954-vobslprh	123	19	immunodominant	immunodominant	JJ
cord-017954-vobslprh	123	20	myelin	myelin	NN
cord-017954-vobslprh	123	21	peptide	peptide	NN
cord-017954-vobslprh	123	22	in	in	IN
cord-017954-vobslprh	123	23	TMEV	TMEV	NNP
cord-017954-vobslprh	123	24	-	-	HYPH
cord-017954-vobslprh	123	25	IDD	IDD	NNP
cord-017954-vobslprh	123	26	in	in	IN
cord-017954-vobslprh	123	27	SJL	SJL	NNP
cord-017954-vobslprh	123	28	mice	mouse	NNS
cord-017954-vobslprh	123	29	,	,	,
cord-017954-vobslprh	123	30	therefore	therefore	RB
cord-017954-vobslprh	123	31	indicating	indicate	VBG
cord-017954-vobslprh	123	32	the	the	DT
cord-017954-vobslprh	123	33	role	role	NN
cord-017954-vobslprh	123	34	of	of	IN
cord-017954-vobslprh	123	35	the	the	DT
cord-017954-vobslprh	123	36	engineered	engineer	VBN
cord-017954-vobslprh	123	37	Haemophilus	Haemophilus	NNP
cord-017954-vobslprh	123	38	influenzae	influenzae	NN
cord-017954-vobslprh	123	39	peptide	peptide	JJ
cord-017954-vobslprh	123	40	sequence	sequence	NN
cord-017954-vobslprh	123	41	in	in	IN
cord-017954-vobslprh	123	42	disease	disease	NN
cord-017954-vobslprh	123	43	induction	induction	NN
cord-017954-vobslprh	123	44	.	.	.
cord-017954-vobslprh	124	1	These	these	DT
cord-017954-vobslprh	124	2	studies	study	NNS
cord-017954-vobslprh	124	3	were	be	VBD
cord-017954-vobslprh	124	4	expanded	expand	VBN
cord-017954-vobslprh	124	5	to	to	TO
cord-017954-vobslprh	124	6	include	include	VB
cord-017954-vobslprh	124	7	TMEV	TMEV	NNP
cord-017954-vobslprh	124	8	expressing	express	VBG
cord-017954-vobslprh	124	9	30-mer	30-mer	CD
cord-017954-vobslprh	124	10	from	from	IN
cord-017954-vobslprh	124	11	murine	murine	JJ
cord-017954-vobslprh	124	12	hepatitis	hepatitis	NN
cord-017954-vobslprh	124	13	virus	virus	NN
cord-017954-vobslprh	124	14	(	(	-LRB-
cord-017954-vobslprh	124	15	MHV	MHV	NNP
cord-017954-vobslprh	124	16	)	)	-RRB-
cord-017954-vobslprh	124	17	,	,	,
cord-017954-vobslprh	124	18	which	which	WDT
cord-017954-vobslprh	124	19	only	only	RB
cord-017954-vobslprh	124	20	shares	share	VBZ
cord-017954-vobslprh	124	21	3/13	3/13	CD
cord-017954-vobslprh	124	22	amino	amino	NN
cord-017954-vobslprh	124	23	acids	acid	NNS
cord-017954-vobslprh	124	24	with	with	IN
cord-017954-vobslprh	124	25	PLP139	PLP139	NNP
cord-017954-vobslprh	124	26	-	-	HYPH
cord-017954-vobslprh	124	27	151	151	CD
cord-017954-vobslprh	124	28	,	,	,
cord-017954-vobslprh	124	29	and	and	CC
cord-017954-vobslprh	124	30	demonstrated	demonstrate	VBD
cord-017954-vobslprh	124	31	the	the	DT
cord-017954-vobslprh	124	32	importance	importance	NN
cord-017954-vobslprh	124	33	of	of	IN
cord-017954-vobslprh	124	34	a	a	DT
cord-017954-vobslprh	124	35	proline	proline	NN
cord-017954-vobslprh	124	36	residue	residue	NN
cord-017954-vobslprh	124	37	at	at	IN
cord-017954-vobslprh	124	38	the	the	DT
cord-017954-vobslprh	124	39	secondary	secondary	JJ
cord-017954-vobslprh	124	40	MHC	MHC	NNP
cord-017954-vobslprh	124	41	class	class	NN
cord-017954-vobslprh	124	42	II	II	NNP
cord-017954-vobslprh	124	43	contact	contact	NN
cord-017954-vobslprh	124	44	point	point	NN
cord-017954-vobslprh	124	45	[	[	-LRB-
cord-017954-vobslprh	124	46	43	43	CD
cord-017954-vobslprh	124	47	]	]	-RRB-
cord-017954-vobslprh	124	48	.	.	.
cord-017954-vobslprh	125	1	Semliki	Semliki	NNP
cord-017954-vobslprh	125	2	Forest	Forest	NNP
cord-017954-vobslprh	125	3	virus	virus	NN
cord-017954-vobslprh	125	4	(	(	-LRB-
cord-017954-vobslprh	125	5	SFV	SFV	NNP
cord-017954-vobslprh	125	6	)	)	-RRB-
cord-017954-vobslprh	125	7	strain	strain	VBP
cord-017954-vobslprh	125	8	A774	A774	NNPS
cord-017954-vobslprh	125	9	is	be	VBZ
cord-017954-vobslprh	125	10	a	a	DT
cord-017954-vobslprh	125	11	neurotropic	neurotropic	NNP
cord-017954-vobslprh	125	12	,	,	,
cord-017954-vobslprh	125	13	single	single	RB
cord-017954-vobslprh	125	14	-	-	HYPH
cord-017954-vobslprh	125	15	stranded	strand	VBN
cord-017954-vobslprh	125	16	RNA	rna	NN
cord-017954-vobslprh	125	17	alphavirus	alphavirus	NN
cord-017954-vobslprh	125	18	of	of	IN
cord-017954-vobslprh	125	19	the	the	DT
cord-017954-vobslprh	125	20	Togaviridae	Togaviridae	NNP
cord-017954-vobslprh	125	21	family	family	NN
cord-017954-vobslprh	125	22	that	that	WDT
cord-017954-vobslprh	125	23	induces	induce	VBZ
cord-017954-vobslprh	125	24	a	a	DT
cord-017954-vobslprh	125	25	demyelinating	demyelinating	JJ
cord-017954-vobslprh	125	26	disease	disease	NN
cord-017954-vobslprh	125	27	upon	upon	IN
cord-017954-vobslprh	125	28	intraperitoneal	intraperitoneal	JJ
cord-017954-vobslprh	125	29	injection	injection	NN
cord-017954-vobslprh	125	30	in	in	IN
cord-017954-vobslprh	125	31	SJL	SJL	NNP
cord-017954-vobslprh	125	32	/	/	SYM
cord-017954-vobslprh	125	33	J	J	NNP
cord-017954-vobslprh	125	34	mice	mouse	NNS
cord-017954-vobslprh	125	35	.	.	.
cord-017954-vobslprh	126	1	Disease	Disease	NNP
cord-017954-vobslprh	126	2	is	be	VBZ
cord-017954-vobslprh	126	3	characterized	characterize	VBN
cord-017954-vobslprh	126	4	by	by	IN
cord-017954-vobslprh	126	5	virus	virus	NN
cord-017954-vobslprh	126	6	-	-	HYPH
cord-017954-vobslprh	126	7	induced	induce	VBN
cord-017954-vobslprh	126	8	demyelination	demyelination	NN
cord-017954-vobslprh	126	9	of	of	IN
cord-017954-vobslprh	126	10	the	the	DT
cord-017954-vobslprh	126	11	CNS	CNS	NNP
cord-017954-vobslprh	126	12	.	.	.
cord-017954-vobslprh	127	1	Despite	despite	IN
cord-017954-vobslprh	127	2	the	the	DT
cord-017954-vobslprh	127	3	clearance	clearance	NN
cord-017954-vobslprh	127	4	of	of	IN
cord-017954-vobslprh	127	5	the	the	DT
cord-017954-vobslprh	127	6	virus	virus	NN
cord-017954-vobslprh	127	7	by	by	IN
cord-017954-vobslprh	127	8	the	the	DT
cord-017954-vobslprh	127	9	immune	immune	JJ
cord-017954-vobslprh	127	10	system	system	NN
cord-017954-vobslprh	127	11	,	,	,
cord-017954-vobslprh	127	12	maximal	maximal	JJ
cord-017954-vobslprh	127	13	demyelinating	demyelinating	JJ
cord-017954-vobslprh	127	14	lesions	lesion	NNS
cord-017954-vobslprh	127	15	with	with	IN
cord-017954-vobslprh	127	16	the	the	DT
cord-017954-vobslprh	127	17	expression	expression	NN
cord-017954-vobslprh	127	18	of	of	IN
cord-017954-vobslprh	127	19	IFN	IFN	NNP
cord-017954-vobslprh	127	20	-	-	HYPH
cord-017954-vobslprh	127	21	γ	γ	NNP
cord-017954-vobslprh	127	22	and	and	CC
cord-017954-vobslprh	127	23	TNF	TNF	NNP
cord-017954-vobslprh	127	24	-	-	HYPH
cord-017954-vobslprh	127	25	α	α	NNP
cord-017954-vobslprh	127	26	are	be	VBP
cord-017954-vobslprh	127	27	observed	observe	VBN
cord-017954-vobslprh	127	28	at	at	IN
cord-017954-vobslprh	127	29	14	14	CD
cord-017954-vobslprh	127	30	days	day	NNS
cord-017954-vobslprh	127	31	post	post	NN
cord-017954-vobslprh	127	32	-	-	NN
cord-017954-vobslprh	127	33	infection	infection	NN
cord-017954-vobslprh	127	34	up	up	IN
cord-017954-vobslprh	127	35	to	to	IN
cord-017954-vobslprh	127	36	1	1	CD
cord-017954-vobslprh	127	37	month	month	NN
cord-017954-vobslprh	127	38	in	in	IN
cord-017954-vobslprh	127	39	BALB	BALB	NNP
cord-017954-vobslprh	127	40	/	/	SYM
cord-017954-vobslprh	127	41	c	c	NN
cord-017954-vobslprh	127	42	mice	mouse	NNS
cord-017954-vobslprh	127	43	,	,	,
cord-017954-vobslprh	127	44	whereas	whereas	IN
cord-017954-vobslprh	127	45	both	both	DT
cord-017954-vobslprh	127	46	demyelination	demyelination	NN
cord-017954-vobslprh	127	47	and	and	CC
cord-017954-vobslprh	127	48	pro	pro	JJ
cord-017954-vobslprh	127	49	-	-	JJ
cord-017954-vobslprh	127	50	inflammatory	inflammatory	JJ
cord-017954-vobslprh	127	51	cytokine	cytokine	NN
cord-017954-vobslprh	127	52	expression	expression	NN
cord-017954-vobslprh	127	53	can	can	MD
cord-017954-vobslprh	127	54	be	be	VB
cord-017954-vobslprh	127	55	detected	detect	VBN
cord-017954-vobslprh	127	56	in	in	IN
cord-017954-vobslprh	127	57	SJL	SJL	NNP
cord-017954-vobslprh	127	58	/	/	SYM
cord-017954-vobslprh	127	59	J	J	NNP
cord-017954-vobslprh	127	60	mice	mouse	NNS
cord-017954-vobslprh	127	61	up	up	IN
cord-017954-vobslprh	127	62	to	to	IN
cord-017954-vobslprh	127	63	1	1	CD
cord-017954-vobslprh	127	64	year	year	NN
cord-017954-vobslprh	127	65	[	[	-LRB-
cord-017954-vobslprh	127	66	44	44	CD
cord-017954-vobslprh	127	67	]	]	-RRB-
cord-017954-vobslprh	127	68	.	.	.
cord-017954-vobslprh	128	1	SFV	sfv	NN
cord-017954-vobslprh	128	2	infection	infection	NN
cord-017954-vobslprh	128	3	induces	induce	VBZ
cord-017954-vobslprh	128	4	an	an	DT
cord-017954-vobslprh	128	5	MBP	MBP	NNP
cord-017954-vobslprh	128	6	-	-	HYPH
cord-017954-vobslprh	128	7	specific	specific	JJ
cord-017954-vobslprh	128	8	T	t	NN
cord-017954-vobslprh	128	9	-	-	HYPH
cord-017954-vobslprh	128	10	cell	cell	NN
cord-017954-vobslprh	128	11	response	response	NN
cord-017954-vobslprh	128	12	[	[	-LRB-
cord-017954-vobslprh	128	13	45	45	CD
cord-017954-vobslprh	128	14	]	]	-RRB-
cord-017954-vobslprh	128	15	and	and	CC
cord-017954-vobslprh	128	16	demyelination	demyelination	NN
cord-017954-vobslprh	128	17	is	be	VBZ
cord-017954-vobslprh	128	18	mediated	mediate	VBN
cord-017954-vobslprh	128	19	by	by	IN
cord-017954-vobslprh	128	20	CD8	CD8	NNP
cord-017954-vobslprh	128	21	T	T	NNP
cord-017954-vobslprh	128	22	cells	cell	NNS
cord-017954-vobslprh	128	23	[	[	-LRB-
cord-017954-vobslprh	128	24	46	46	CD
cord-017954-vobslprh	128	25	,	,	,
cord-017954-vobslprh	128	26	47	47	CD
cord-017954-vobslprh	128	27	]	]	-RRB-
cord-017954-vobslprh	128	28	.	.	.
cord-017954-vobslprh	129	1	MHV	MHV	NNP
cord-017954-vobslprh	129	2	,	,	,
cord-017954-vobslprh	129	3	a	a	DT
cord-017954-vobslprh	129	4	group	group	NN
cord-017954-vobslprh	129	5	II	ii	CD
cord-017954-vobslprh	129	6	positive	positive	JJ
cord-017954-vobslprh	129	7	-	-	HYPH
cord-017954-vobslprh	129	8	strand	strand	NN
cord-017954-vobslprh	129	9	RNA	RNA	NNP
cord-017954-vobslprh	129	10	coronavirus	coronavirus	NN
cord-017954-vobslprh	129	11	,	,	,
cord-017954-vobslprh	129	12	is	be	VBZ
cord-017954-vobslprh	129	13	a	a	DT
cord-017954-vobslprh	129	14	natural	natural	JJ
cord-017954-vobslprh	129	15	pathogen	pathogen	NN
cord-017954-vobslprh	129	16	of	of	IN
cord-017954-vobslprh	129	17	mice	mouse	NNS
cord-017954-vobslprh	129	18	that	that	IN
cord-017954-vobslprh	129	19	upon	upon	IN
cord-017954-vobslprh	129	20	intracranial	intracranial	JJ
cord-017954-vobslprh	129	21	injection	injection	NN
cord-017954-vobslprh	129	22	causes	cause	VBZ
cord-017954-vobslprh	129	23	an	an	DT
cord-017954-vobslprh	129	24	acute	acute	JJ
cord-017954-vobslprh	129	25	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	129	26	that	that	WDT
cord-017954-vobslprh	129	27	develops	develop	VBZ
cord-017954-vobslprh	129	28	into	into	IN
cord-017954-vobslprh	129	29	a	a	DT
cord-017954-vobslprh	129	30	chronic	chronic	JJ
cord-017954-vobslprh	129	31	CNS	CNS	NNP
cord-017954-vobslprh	129	32	immune	immune	NN
cord-017954-vobslprh	129	33	-	-	HYPH
cord-017954-vobslprh	129	34	mediated	mediate	VBN
cord-017954-vobslprh	129	35	demyelinating	demyelinating	NN
cord-017954-vobslprh	129	36	disease	disease	NN
cord-017954-vobslprh	129	37	with	with	IN
cord-017954-vobslprh	129	38	some	some	DT
cord-017954-vobslprh	129	39	clinical	clinical	JJ
cord-017954-vobslprh	129	40	and	and	CC
cord-017954-vobslprh	129	41	pathological	pathological	JJ
cord-017954-vobslprh	129	42	similarities	similarity	NNS
cord-017954-vobslprh	129	43	with	with	IN
cord-017954-vobslprh	129	44	MS	MS	NNP
cord-017954-vobslprh	129	45	[	[	-LRB-
cord-017954-vobslprh	129	46	48	48	CD
cord-017954-vobslprh	129	47	]	]	-RRB-
cord-017954-vobslprh	129	48	.	.	.
cord-017954-vobslprh	130	1	MHV	MHV	NNP
cord-017954-vobslprh	130	2	can	can	MD
cord-017954-vobslprh	130	3	induce	induce	VB
cord-017954-vobslprh	130	4	either	either	CC
cord-017954-vobslprh	130	5	acute	acute	JJ
cord-017954-vobslprh	130	6	or	or	CC
cord-017954-vobslprh	130	7	chronic	chronic	JJ
cord-017954-vobslprh	130	8	forms	form	NNS
cord-017954-vobslprh	130	9	of	of	IN
cord-017954-vobslprh	130	10	disease	disease	NN
cord-017954-vobslprh	130	11	.	.	.
cord-017954-vobslprh	131	1	The	the	DT
cord-017954-vobslprh	131	2	acute	acute	JJ
cord-017954-vobslprh	131	3	form	form	NN
cord-017954-vobslprh	131	4	is	be	VBZ
cord-017954-vobslprh	131	5	characterized	characterize	VBN
cord-017954-vobslprh	131	6	by	by	IN
cord-017954-vobslprh	131	7	the	the	DT
cord-017954-vobslprh	131	8	production	production	NN
cord-017954-vobslprh	131	9	of	of	IN
cord-017954-vobslprh	131	10	pro	pro	JJ
cord-017954-vobslprh	131	11	-	-	JJ
cord-017954-vobslprh	131	12	inflammatory	inflammatory	JJ
cord-017954-vobslprh	131	13	cytokines	cytokine	NNS
cord-017954-vobslprh	131	14	and	and	CC
cord-017954-vobslprh	131	15	chemokines	chemokine	NNS
cord-017954-vobslprh	131	16	that	that	WDT
cord-017954-vobslprh	131	17	eventually	eventually	RB
cord-017954-vobslprh	131	18	reduce	reduce	VBP
cord-017954-vobslprh	131	19	MHV	MHV	NNP
cord-017954-vobslprh	131	20	viral	viral	JJ
cord-017954-vobslprh	131	21	load	load	NN
cord-017954-vobslprh	131	22	in	in	IN
cord-017954-vobslprh	131	23	the	the	DT
cord-017954-vobslprh	131	24	CNS	CNS	NNP
cord-017954-vobslprh	131	25	.	.	.
cord-017954-vobslprh	132	1	However	however	RB
cord-017954-vobslprh	132	2	,	,	,
cord-017954-vobslprh	132	3	persistent	persistent	JJ
cord-017954-vobslprh	132	4	infection	infection	NN
cord-017954-vobslprh	132	5	of	of	IN
cord-017954-vobslprh	132	6	spinal	spinal	JJ
cord-017954-vobslprh	132	7	cord	cord	NN
cord-017954-vobslprh	132	8	white	white	JJ
cord-017954-vobslprh	132	9	matter	matter	NN
cord-017954-vobslprh	132	10	tracts	tract	NNS
cord-017954-vobslprh	132	11	propagates	propagate	VBZ
cord-017954-vobslprh	132	12	and	and	CC
cord-017954-vobslprh	132	13	promotes	promote	VBZ
cord-017954-vobslprh	132	14	antiviral	antiviral	JJ
cord-017954-vobslprh	132	15	responses	response	NNS
cord-017954-vobslprh	132	16	that	that	WDT
cord-017954-vobslprh	132	17	cause	cause	VBP
cord-017954-vobslprh	132	18	demyelination	demyelination	NN
cord-017954-vobslprh	132	19	leading	lead	VBG
cord-017954-vobslprh	132	20	to	to	IN
cord-017954-vobslprh	132	21	symptoms	symptom	NNS
cord-017954-vobslprh	132	22	of	of	IN
cord-017954-vobslprh	132	23	limp	limp	JJ
cord-017954-vobslprh	132	24	tails	tail	NNS
cord-017954-vobslprh	132	25	and	and	CC
cord-017954-vobslprh	132	26	partial	partial	JJ
cord-017954-vobslprh	132	27	to	to	TO
cord-017954-vobslprh	132	28	complete	complete	VB
cord-017954-vobslprh	132	29	hind	hind	JJ
cord-017954-vobslprh	132	30	-	-	HYPH
cord-017954-vobslprh	132	31	limb	limb	NN
cord-017954-vobslprh	132	32	paralysis	paralysis	NN
cord-017954-vobslprh	132	33	,	,	,
cord-017954-vobslprh	132	34	similar	similar	JJ
cord-017954-vobslprh	132	35	to	to	IN
cord-017954-vobslprh	132	36	that	that	DT
cord-017954-vobslprh	132	37	in	in	IN
cord-017954-vobslprh	132	38	EAE	EAE	NNP
cord-017954-vobslprh	132	39	.	.	.
cord-017954-vobslprh	133	1	In	in	IN
cord-017954-vobslprh	133	2	contrast	contrast	NN
cord-017954-vobslprh	133	3	to	to	IN
cord-017954-vobslprh	133	4	EAE	EAE	NNP
cord-017954-vobslprh	133	5	and	and	CC
cord-017954-vobslprh	133	6	other	other	JJ
cord-017954-vobslprh	133	7	viral	viral	JJ
cord-017954-vobslprh	133	8	models	model	NNS
cord-017954-vobslprh	133	9	of	of	IN
cord-017954-vobslprh	133	10	CNS	CNS	NNP
cord-017954-vobslprh	133	11	demyelinating	demyelinating	NN
cord-017954-vobslprh	133	12	disease	disease	NN
cord-017954-vobslprh	133	13	,	,	,
cord-017954-vobslprh	133	14	myelin	myelin	NN
cord-017954-vobslprh	133	15	-	-	HYPH
cord-017954-vobslprh	133	16	specific	specific	JJ
cord-017954-vobslprh	133	17	T	t	NN
cord-017954-vobslprh	133	18	cells	cell	NNS
cord-017954-vobslprh	133	19	and	and	CC
cord-017954-vobslprh	133	20	epitope	epitope	NN
cord-017954-vobslprh	133	21	spreading	spreading	NN
cord-017954-vobslprh	133	22	are	be	VBP
cord-017954-vobslprh	133	23	not	not	RB
cord-017954-vobslprh	133	24	thought	think	VBN
cord-017954-vobslprh	133	25	to	to	TO
cord-017954-vobslprh	133	26	be	be	VB
cord-017954-vobslprh	133	27	required	require	VBN
cord-017954-vobslprh	133	28	for	for	IN
cord-017954-vobslprh	133	29	demyelination	demyelination	NN
cord-017954-vobslprh	133	30	;	;	:
cord-017954-vobslprh	133	31	rather	rather	RB
cord-017954-vobslprh	133	32	it	-PRON-	PRP
cord-017954-vobslprh	133	33	is	be	VBZ
cord-017954-vobslprh	133	34	the	the	DT
cord-017954-vobslprh	133	35	persistent	persistent	JJ
cord-017954-vobslprh	133	36	effect	effect	NN
cord-017954-vobslprh	133	37	of	of	IN
cord-017954-vobslprh	133	38	antiviral	antiviral	JJ
cord-017954-vobslprh	133	39	immune	immune	JJ
cord-017954-vobslprh	133	40	responses	response	NNS
cord-017954-vobslprh	133	41	including	include	VBG
cord-017954-vobslprh	133	42	macrophages	macrophage	NNS
cord-017954-vobslprh	133	43	and	and	CC
cord-017954-vobslprh	133	44	CD4þ	CD4þ	NNP
cord-017954-vobslprh	133	45	and	and	CC
cord-017954-vobslprh	133	46	CD8þ	CD8þ	NNP
cord-017954-vobslprh	133	47	T	T	NNP
cord-017954-vobslprh	133	48	cells	cell	NNS
cord-017954-vobslprh	133	49	that	that	WDT
cord-017954-vobslprh	133	50	cause	cause	VBP
cord-017954-vobslprh	133	51	chronic	chronic	JJ
cord-017954-vobslprh	133	52	demyelination	demyelination	NN
cord-017954-vobslprh	133	53	(	(	-LRB-
cord-017954-vobslprh	133	54	reviewed	review	VBN
cord-017954-vobslprh	133	55	by	by	IN
cord-017954-vobslprh	133	56	Lane	Lane	NNP
cord-017954-vobslprh	133	57	2010	2010	CD
cord-017954-vobslprh	133	58	)	)	-RRB-
cord-017954-vobslprh	134	1	[	[	-LRB-
cord-017954-vobslprh	134	2	49	49	CD
cord-017954-vobslprh	134	3	]	]	-RRB-
cord-017954-vobslprh	134	4	.	.	.
cord-017954-vobslprh	135	1	In	in	IN
cord-017954-vobslprh	135	2	summary	summary	NN
cord-017954-vobslprh	135	3	,	,	,
cord-017954-vobslprh	135	4	TMEV	TMEV	NNP
cord-017954-vobslprh	135	5	-	-	HYPH
cord-017954-vobslprh	135	6	IDD	IDD	NNP
cord-017954-vobslprh	135	7	is	be	VBZ
cord-017954-vobslprh	135	8	a	a	DT
cord-017954-vobslprh	135	9	demyelinating	demyelinating	JJ
cord-017954-vobslprh	135	10	model	model	NN
cord-017954-vobslprh	135	11	that	that	WDT
cord-017954-vobslprh	135	12	is	be	VBZ
cord-017954-vobslprh	135	13	associated	associate	VBN
cord-017954-vobslprh	135	14	with	with	IN
cord-017954-vobslprh	135	15	persistent	persistent	JJ
cord-017954-vobslprh	135	16	infection	infection	NN
cord-017954-vobslprh	135	17	of	of	IN
cord-017954-vobslprh	135	18	the	the	DT
cord-017954-vobslprh	135	19	CNS	CNS	NNP
cord-017954-vobslprh	135	20	,	,	,
cord-017954-vobslprh	135	21	whereas	whereas	IN
cord-017954-vobslprh	135	22	SFV	sfv	NN
cord-017954-vobslprh	135	23	infection	infection	NN
cord-017954-vobslprh	135	24	of	of	IN
cord-017954-vobslprh	135	25	SJL	SJL	NNP
cord-017954-vobslprh	135	26	mice	mouse	NNS
cord-017954-vobslprh	135	27	might	may	MD
cord-017954-vobslprh	135	28	represent	represent	VB
cord-017954-vobslprh	135	29	a	a	DT
cord-017954-vobslprh	135	30	model	model	NN
cord-017954-vobslprh	135	31	of	of	IN
cord-017954-vobslprh	135	32	MS	MS	NNP
cord-017954-vobslprh	135	33	where	where	WRB
cord-017954-vobslprh	135	34	immune	immune	NN
cord-017954-vobslprh	135	35	-	-	HYPH
cord-017954-vobslprh	135	36	mediated	mediate	VBN
cord-017954-vobslprh	135	37	demyelination	demyelination	NN
cord-017954-vobslprh	135	38	is	be	VBZ
cord-017954-vobslprh	135	39	triggered	trigger	VBN
cord-017954-vobslprh	135	40	by	by	IN
cord-017954-vobslprh	135	41	a	a	DT
cord-017954-vobslprh	135	42	virus	virus	NN
cord-017954-vobslprh	135	43	infection	infection	NN
cord-017954-vobslprh	135	44	of	of	IN
cord-017954-vobslprh	135	45	the	the	DT
cord-017954-vobslprh	135	46	CNS	CNS	NNP
cord-017954-vobslprh	135	47	that	that	WDT
cord-017954-vobslprh	135	48	is	be	VBZ
cord-017954-vobslprh	135	49	cleared	clear	VBN
cord-017954-vobslprh	135	50	efficiently	efficiently	RB
cord-017954-vobslprh	135	51	by	by	IN
cord-017954-vobslprh	135	52	the	the	DT
cord-017954-vobslprh	135	53	host	host	NN
cord-017954-vobslprh	135	54	immune	immune	JJ
cord-017954-vobslprh	135	55	system	system	NN
cord-017954-vobslprh	135	56	.	.	.
cord-017954-vobslprh	136	1	Although	although	IN
cord-017954-vobslprh	136	2	some	some	DT
cord-017954-vobslprh	136	3	studies	study	NNS
cord-017954-vobslprh	136	4	have	have	VBP
cord-017954-vobslprh	136	5	indicated	indicate	VBN
cord-017954-vobslprh	136	6	MS	MS	NNP
cord-017954-vobslprh	136	7	might	may	MD
cord-017954-vobslprh	136	8	have	have	VB
cord-017954-vobslprh	136	9	a	a	DT
cord-017954-vobslprh	136	10	viral	viral	JJ
cord-017954-vobslprh	136	11	aetiology	aetiology	NN
cord-017954-vobslprh	136	12	,	,	,
cord-017954-vobslprh	136	13	the	the	DT
cord-017954-vobslprh	136	14	mechanisms	mechanism	NNS
cord-017954-vobslprh	136	15	involved	involve	VBN
cord-017954-vobslprh	136	16	are	be	VBP
cord-017954-vobslprh	136	17	unknown	unknown	JJ
cord-017954-vobslprh	136	18	but	but	CC
cord-017954-vobslprh	136	19	might	may	MD
cord-017954-vobslprh	136	20	involve	involve	VB
cord-017954-vobslprh	136	21	an	an	DT
cord-017954-vobslprh	136	22	infection	infection	NN
cord-017954-vobslprh	136	23	in	in	IN
cord-017954-vobslprh	136	24	early	early	JJ
cord-017954-vobslprh	136	25	life	life	NN
cord-017954-vobslprh	136	26	that	that	WDT
cord-017954-vobslprh	136	27	primes	prime	VBZ
cord-017954-vobslprh	136	28	autoreactive	autoreactive	JJ
cord-017954-vobslprh	136	29	T	t	NN
cord-017954-vobslprh	136	30	cells	cell	NNS
cord-017954-vobslprh	136	31	by	by	IN
cord-017954-vobslprh	136	32	molecular	molecular	JJ
cord-017954-vobslprh	136	33	mimicry	mimicry	NN
cord-017954-vobslprh	136	34	or	or	CC
cord-017954-vobslprh	136	35	a	a	DT
cord-017954-vobslprh	136	36	persistent	persistent	JJ
cord-017954-vobslprh	136	37	infection	infection	NN
cord-017954-vobslprh	136	38	of	of	IN
cord-017954-vobslprh	136	39	the	the	DT
cord-017954-vobslprh	136	40	CNS	CNS	NNP
cord-017954-vobslprh	136	41	that	that	WDT
cord-017954-vobslprh	136	42	causes	cause	VBZ
cord-017954-vobslprh	136	43	demyelination	demyelination	NN
cord-017954-vobslprh	136	44	via	via	IN
cord-017954-vobslprh	136	45	epitope	epitope	NN
cord-017954-vobslprh	136	46	spreading	spread	VBG
cord-017954-vobslprh	136	47	and/or	and/or	CC
cord-017954-vobslprh	136	48	molecular	molecular	JJ
cord-017954-vobslprh	136	49	mimicry	mimicry	NN
cord-017954-vobslprh	136	50	[	[	-LRB-
cord-017954-vobslprh	136	51	50	50	CD
cord-017954-vobslprh	136	52	]	]	-RRB-
cord-017954-vobslprh	136	53	.	.	.
cord-017954-vobslprh	137	1	Thus	thus	RB
cord-017954-vobslprh	137	2	,	,	,
cord-017954-vobslprh	137	3	both	both	DT
cord-017954-vobslprh	137	4	mouse	mouse	NN
cord-017954-vobslprh	137	5	models	model	NNS
cord-017954-vobslprh	137	6	allow	allow	VBP
cord-017954-vobslprh	137	7	the	the	DT
cord-017954-vobslprh	137	8	study	study	NN
cord-017954-vobslprh	137	9	of	of	IN
cord-017954-vobslprh	137	10	how	how	WRB
cord-017954-vobslprh	137	11	viruses	virus	NNS
cord-017954-vobslprh	137	12	might	may	MD
cord-017954-vobslprh	137	13	induce	induce	VB
cord-017954-vobslprh	137	14	CNS	CNS	NNP
cord-017954-vobslprh	137	15	demeylinating	demeylinate	VBG
cord-017954-vobslprh	137	16	autoimmune	autoimmune	JJ
cord-017954-vobslprh	137	17	disease	disease	NN
cord-017954-vobslprh	137	18	.	.	.
cord-017954-vobslprh	138	1	In	in	IN
cord-017954-vobslprh	138	2	contrast	contrast	NN
cord-017954-vobslprh	138	3	,	,	,
cord-017954-vobslprh	138	4	MHV	MHV	NNP
cord-017954-vobslprh	138	5	provides	provide	VBZ
cord-017954-vobslprh	138	6	a	a	DT
cord-017954-vobslprh	138	7	different	different	JJ
cord-017954-vobslprh	138	8	scope	scope	NN
cord-017954-vobslprh	138	9	for	for	IN
cord-017954-vobslprh	138	10	study	study	NN
cord-017954-vobslprh	138	11	,	,	,
cord-017954-vobslprh	138	12	the	the	DT
cord-017954-vobslprh	138	13	underlying	underlie	VBG
cord-017954-vobslprh	138	14	mechanisms	mechanism	NNS
cord-017954-vobslprh	138	15	that	that	WDT
cord-017954-vobslprh	138	16	mediate	mediate	VBP
cord-017954-vobslprh	138	17	host	host	NN
cord-017954-vobslprh	138	18	defence	defence	NN
cord-017954-vobslprh	138	19	against	against	IN
cord-017954-vobslprh	138	20	an	an	DT
cord-017954-vobslprh	138	21	acute	acute	JJ
cord-017954-vobslprh	138	22	viral	viral	JJ
cord-017954-vobslprh	138	23	infection	infection	NN
cord-017954-vobslprh	138	24	that	that	WDT
cord-017954-vobslprh	138	25	later	later	RB
cord-017954-vobslprh	138	26	becomes	become	VBZ
cord-017954-vobslprh	138	27	chronic	chronic	JJ
cord-017954-vobslprh	138	28	and	and	CC
cord-017954-vobslprh	138	29	which	which	WDT
cord-017954-vobslprh	138	30	is	be	VBZ
cord-017954-vobslprh	138	31	associated	associate	VBN
cord-017954-vobslprh	138	32	with	with	IN
cord-017954-vobslprh	138	33	CNS	CNS	NNP
cord-017954-vobslprh	138	34	demyelination	demyelination	NN
cord-017954-vobslprh	138	35	and	and	CC
cord-017954-vobslprh	138	36	neurological	neurological	JJ
cord-017954-vobslprh	138	37	symptoms	symptom	NNS
cord-017954-vobslprh	138	38	in	in	IN
cord-017954-vobslprh	138	39	the	the	DT
cord-017954-vobslprh	138	40	absence	absence	NN
cord-017954-vobslprh	138	41	of	of	IN
cord-017954-vobslprh	138	42	myelin	myelin	NN
cord-017954-vobslprh	138	43	-	-	HYPH
cord-017954-vobslprh	138	44	specific	specific	JJ
cord-017954-vobslprh	138	45	T	t	NN
cord-017954-vobslprh	138	46	-	-	HYPH
cord-017954-vobslprh	138	47	cell	cell	NN
cord-017954-vobslprh	138	48	responses	response	NNS
cord-017954-vobslprh	138	49	.	.	.
cord-017954-vobslprh	139	1	Guillain	Guillain	NNP
cord-017954-vobslprh	139	2	-	-	HYPH
cord-017954-vobslprh	139	3	Barré	Barré	NNP
cord-017954-vobslprh	139	4	syndrome	syndrome	NN
cord-017954-vobslprh	139	5	(	(	-LRB-
cord-017954-vobslprh	139	6	GBS	GBS	NNP
cord-017954-vobslprh	139	7	)	)	-RRB-
cord-017954-vobslprh	139	8	is	be	VBZ
cord-017954-vobslprh	139	9	a	a	DT
cord-017954-vobslprh	139	10	rapid	rapid	JJ
cord-017954-vobslprh	139	11	autoimmune	autoimmune	NN
cord-017954-vobslprh	139	12	-	-	HYPH
cord-017954-vobslprh	139	13	mediated	mediate	VBN
cord-017954-vobslprh	139	14	acute	acute	JJ
cord-017954-vobslprh	139	15	disease	disease	NN
cord-017954-vobslprh	139	16	of	of	IN
cord-017954-vobslprh	139	17	the	the	DT
cord-017954-vobslprh	139	18	peripheral	peripheral	JJ
cord-017954-vobslprh	139	19	nervous	nervous	JJ
cord-017954-vobslprh	139	20	system	system	NN
cord-017954-vobslprh	139	21	,	,	,
cord-017954-vobslprh	139	22	which	which	WDT
cord-017954-vobslprh	139	23	is	be	VBZ
cord-017954-vobslprh	139	24	often	often	RB
cord-017954-vobslprh	139	25	caused	cause	VBN
cord-017954-vobslprh	139	26	by	by	IN
cord-017954-vobslprh	139	27	infection	infection	NN
cord-017954-vobslprh	139	28	with	with	IN
cord-017954-vobslprh	139	29	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	139	30	jejuni	jejuni	NNP
cord-017954-vobslprh	139	31	.	.	.
cord-017954-vobslprh	140	1	Clinical	clinical	JJ
cord-017954-vobslprh	140	2	disease	disease	NN
cord-017954-vobslprh	140	3	characteristics	characteristic	NNS
cord-017954-vobslprh	140	4	usually	usually	RB
cord-017954-vobslprh	140	5	occur	occur	VBP
cord-017954-vobslprh	140	6	rapidly	rapidly	RB
cord-017954-vobslprh	140	7	following	follow	VBG
cord-017954-vobslprh	140	8	onset	onset	NN
cord-017954-vobslprh	140	9	,	,	,
cord-017954-vobslprh	140	10	usually	usually	RB
cord-017954-vobslprh	140	11	within	within	IN
cord-017954-vobslprh	140	12	4	4	CD
cord-017954-vobslprh	140	13	weeks	week	NNS
cord-017954-vobslprh	140	14	,	,	,
cord-017954-vobslprh	140	15	and	and	CC
cord-017954-vobslprh	140	16	include	include	VBP
cord-017954-vobslprh	140	17	neuromuscular	neuromuscular	JJ
cord-017954-vobslprh	140	18	paralysis	paralysis	NN
cord-017954-vobslprh	140	19	,	,	,
cord-017954-vobslprh	140	20	progressive	progressive	JJ
cord-017954-vobslprh	140	21	limb	limb	NN
cord-017954-vobslprh	140	22	weakness	weakness	NN
cord-017954-vobslprh	140	23	,	,	,
cord-017954-vobslprh	140	24	and	and	CC
cord-017954-vobslprh	140	25	deficits	deficit	NNS
cord-017954-vobslprh	140	26	of	of	IN
cord-017954-vobslprh	140	27	the	the	DT
cord-017954-vobslprh	140	28	sensory	sensory	JJ
cord-017954-vobslprh	140	29	and	and	CC
cord-017954-vobslprh	140	30	autonomic	autonomic	JJ
cord-017954-vobslprh	140	31	systems	system	NNS
cord-017954-vobslprh	140	32	as	as	RB
cord-017954-vobslprh	140	33	well	well	RB
cord-017954-vobslprh	140	34	as	as	IN
cord-017954-vobslprh	140	35	cranial	cranial	JJ
cord-017954-vobslprh	140	36	nerve	nerve	NN
cord-017954-vobslprh	140	37	involvement	involvement	NN
cord-017954-vobslprh	140	38	.	.	.
cord-017954-vobslprh	141	1	The	the	DT
cord-017954-vobslprh	141	2	generation	generation	NN
cord-017954-vobslprh	141	3	of	of	IN
cord-017954-vobslprh	141	4	antibodies	antibody	NNS
cord-017954-vobslprh	141	5	to	to	IN
cord-017954-vobslprh	141	6	cell	cell	NN
cord-017954-vobslprh	141	7	-	-	HYPH
cord-017954-vobslprh	141	8	surface	surface	NN
cord-017954-vobslprh	141	9	gangliosides	ganglioside	NNS
cord-017954-vobslprh	141	10	highly	highly	RB
cord-017954-vobslprh	141	11	expressed	express	VBN
cord-017954-vobslprh	141	12	on	on	IN
cord-017954-vobslprh	141	13	peripheral	peripheral	JJ
cord-017954-vobslprh	141	14	nerves	nerve	NNS
cord-017954-vobslprh	141	15	by	by	IN
cord-017954-vobslprh	141	16	cross	cross	NN
cord-017954-vobslprh	141	17	-	-	NN
cord-017954-vobslprh	141	18	reactivity	reactivity	NN
cord-017954-vobslprh	141	19	to	to	IN
cord-017954-vobslprh	141	20	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	141	21	jejuni	jejuni	NNP
cord-017954-vobslprh	141	22	outer	outer	JJ
cord-017954-vobslprh	141	23	membrane	membrane	NN
cord-017954-vobslprh	141	24	components	component	NNS
cord-017954-vobslprh	141	25	(	(	-LRB-
cord-017954-vobslprh	141	26	lipo	lipo	NN
cord-017954-vobslprh	141	27	-	-	HYPH
cord-017954-vobslprh	141	28	oligosaccharides	oligosaccharide	NNS
cord-017954-vobslprh	141	29	)	)	-RRB-
cord-017954-vobslprh	141	30	mediates	mediate	VBZ
cord-017954-vobslprh	141	31	disease	disease	NN
cord-017954-vobslprh	141	32	[	[	-LRB-
cord-017954-vobslprh	141	33	51	51	CD
cord-017954-vobslprh	141	34	]	]	-RRB-
cord-017954-vobslprh	141	35	and	and	CC
cord-017954-vobslprh	141	36	is	be	VBZ
cord-017954-vobslprh	141	37	thought	think	VBN
cord-017954-vobslprh	141	38	to	to	TO
cord-017954-vobslprh	141	39	be	be	VB
cord-017954-vobslprh	141	40	caused	cause	VBN
cord-017954-vobslprh	141	41	by	by	IN
cord-017954-vobslprh	141	42	postinfectious	postinfectious	NNP
cord-017954-vobslprh	141	43	molecular	molecular	JJ
cord-017954-vobslprh	141	44	mimicry	mimicry	NN
cord-017954-vobslprh	141	45	(	(	-LRB-
cord-017954-vobslprh	141	46	reviewed	review	VBN
cord-017954-vobslprh	141	47	by	by	IN
cord-017954-vobslprh	141	48	Shahrizaila	Shahrizaila	NNP
cord-017954-vobslprh	141	49	2011	2011	CD
cord-017954-vobslprh	141	50	)	)	-RRB-
cord-017954-vobslprh	142	1	[	[	-LRB-
cord-017954-vobslprh	142	2	52	52	CD
cord-017954-vobslprh	142	3	]	]	-RRB-
cord-017954-vobslprh	142	4	.	.	.
cord-017954-vobslprh	143	1	Two	two	CD
cord-017954-vobslprh	143	2	forms	form	NNS
cord-017954-vobslprh	143	3	of	of	IN
cord-017954-vobslprh	143	4	GBS	GBS	NNP
cord-017954-vobslprh	143	5	have	have	VBP
cord-017954-vobslprh	143	6	been	be	VBN
cord-017954-vobslprh	143	7	characterized	characterize	VBN
cord-017954-vobslprh	143	8	:	:	:
cord-017954-vobslprh	143	9	(	(	-LRB-
cord-017954-vobslprh	143	10	i	i	NN
cord-017954-vobslprh	143	11	)	)	-RRB-
cord-017954-vobslprh	143	12	a	a	DT
cord-017954-vobslprh	143	13	primary	primary	JJ
cord-017954-vobslprh	143	14	demyelinating	demyelinating	NN
cord-017954-vobslprh	143	15	form	form	NN
cord-017954-vobslprh	143	16	(	(	-LRB-
cord-017954-vobslprh	143	17	acute	acute	JJ
cord-017954-vobslprh	143	18	inflammatory	inflammatory	JJ
cord-017954-vobslprh	143	19	demyelinating	demyelinating	NN
cord-017954-vobslprh	143	20	polyradiculoneuropathy	polyradiculoneuropathy	JJ
cord-017954-vobslprh	143	21	[	[	-LRB-
cord-017954-vobslprh	143	22	AIDP	AIDP	NNP
cord-017954-vobslprh	143	23	]	]	-RRB-
cord-017954-vobslprh	143	24	)	)	-RRB-
cord-017954-vobslprh	144	1	and	and	CC
cord-017954-vobslprh	144	2	(	(	-LRB-
cord-017954-vobslprh	144	3	ii	ii	LS
cord-017954-vobslprh	144	4	)	)	-RRB-
cord-017954-vobslprh	144	5	those	those	DT
cord-017954-vobslprh	144	6	with	with	IN
cord-017954-vobslprh	144	7	axonal	axonal	JJ
cord-017954-vobslprh	144	8	involvement	involvement	NN
cord-017954-vobslprh	144	9	(	(	-LRB-
cord-017954-vobslprh	144	10	acute	acute	JJ
cord-017954-vobslprh	144	11	motor	motor	NN
cord-017954-vobslprh	144	12	axonal	axonal	JJ
cord-017954-vobslprh	144	13	neuropathy	neuropathy	NN
cord-017954-vobslprh	144	14	[	[	-LRB-
cord-017954-vobslprh	144	15	AMAN	AMAN	NNP
cord-017954-vobslprh	144	16	]	]	-RRB-
cord-017954-vobslprh	144	17	,	,	,
cord-017954-vobslprh	144	18	acute	acute	JJ
cord-017954-vobslprh	144	19	motorsensory	motorsensory	JJ
cord-017954-vobslprh	144	20	axonal	axonal	JJ
cord-017954-vobslprh	144	21	neuropathy	neuropathy	NN
cord-017954-vobslprh	144	22	[	[	-LRB-
cord-017954-vobslprh	144	23	AMSAN	AMSAN	NNP
cord-017954-vobslprh	144	24	]	]	-RRB-
cord-017954-vobslprh	144	25	)	)	-RRB-
cord-017954-vobslprh	144	26	,	,	,
cord-017954-vobslprh	144	27	with	with	IN
cord-017954-vobslprh	144	28	either	either	CC
cord-017954-vobslprh	144	29	the	the	DT
cord-017954-vobslprh	144	30	presence	presence	NN
cord-017954-vobslprh	144	31	or	or	CC
cord-017954-vobslprh	144	32	absence	absence	NN
cord-017954-vobslprh	144	33	of	of	IN
cord-017954-vobslprh	144	34	antiganglioside	antiganglioside	JJ
cord-017954-vobslprh	144	35	antibodies	antibody	NNS
cord-017954-vobslprh	144	36	[	[	-LRB-
cord-017954-vobslprh	144	37	53	53	CD
cord-017954-vobslprh	144	38	,	,	,
cord-017954-vobslprh	144	39	54	54	CD
cord-017954-vobslprh	144	40	]	]	-RRB-
cord-017954-vobslprh	144	41	.	.	.
cord-017954-vobslprh	145	1	The	the	DT
cord-017954-vobslprh	145	2	pathogenic	pathogenic	JJ
cord-017954-vobslprh	145	3	mechanisms	mechanism	NNS
cord-017954-vobslprh	145	4	of	of	IN
cord-017954-vobslprh	145	5	the	the	DT
cord-017954-vobslprh	145	6	AIDP	AIDP	NNP
cord-017954-vobslprh	145	7	form	form	NN
cord-017954-vobslprh	145	8	of	of	IN
cord-017954-vobslprh	145	9	GBS	GBS	NNP
cord-017954-vobslprh	145	10	include	include	VBP
cord-017954-vobslprh	145	11	the	the	DT
cord-017954-vobslprh	145	12	demyelination	demyelination	NN
cord-017954-vobslprh	145	13	of	of	IN
cord-017954-vobslprh	145	14	the	the	DT
cord-017954-vobslprh	145	15	peripheral	peripheral	JJ
cord-017954-vobslprh	145	16	nerve	nerve	NN
cord-017954-vobslprh	145	17	myelin	myelin	NN
cord-017954-vobslprh	145	18	sheath	sheath	NN
cord-017954-vobslprh	145	19	by	by	IN
cord-017954-vobslprh	145	20	inflammation	inflammation	NN
cord-017954-vobslprh	145	21	including	include	VBG
cord-017954-vobslprh	145	22	upregulated	upregulate	VBN
cord-017954-vobslprh	145	23	adhesion	adhesion	NN
cord-017954-vobslprh	145	24	molecules	molecule	NNS
cord-017954-vobslprh	145	25	,	,	,
cord-017954-vobslprh	145	26	pro	pro	JJ
cord-017954-vobslprh	145	27	-	-	JJ
cord-017954-vobslprh	145	28	inflammatory	inflammatory	JJ
cord-017954-vobslprh	145	29	cytokines	cytokine	NNS
cord-017954-vobslprh	145	30	,	,	,
cord-017954-vobslprh	145	31	and	and	CC
cord-017954-vobslprh	145	32	the	the	DT
cord-017954-vobslprh	145	33	infiltration	infiltration	NN
cord-017954-vobslprh	145	34	of	of	IN
cord-017954-vobslprh	145	35	CD4þ	CD4þ	NNP
cord-017954-vobslprh	145	36	T	T	NNP
cord-017954-vobslprh	145	37	cells	cell	NNS
cord-017954-vobslprh	145	38	and	and	CC
cord-017954-vobslprh	145	39	plasma	plasma	NN
cord-017954-vobslprh	145	40	cells	cell	NNS
cord-017954-vobslprh	145	41	secreting	secrete	VBG
cord-017954-vobslprh	145	42	anti	anti	JJ
cord-017954-vobslprh	145	43	-	-	JJ
cord-017954-vobslprh	145	44	ganglioside	ganglioside	JJ
cord-017954-vobslprh	145	45	antibodies	antibody	NNS
cord-017954-vobslprh	145	46	and	and	CC
cord-017954-vobslprh	145	47	macrophages	macrophage	NNS
cord-017954-vobslprh	145	48	[	[	-LRB-
cord-017954-vobslprh	145	49	53	53	CD
cord-017954-vobslprh	145	50	]	]	-RRB-
cord-017954-vobslprh	145	51	[	[	-LRB-
cord-017954-vobslprh	145	52	54	54	CD
cord-017954-vobslprh	145	53	]	]	-RRB-
cord-017954-vobslprh	145	54	[	[	-LRB-
cord-017954-vobslprh	145	55	55	55	CD
cord-017954-vobslprh	145	56	]	]	-RRB-
cord-017954-vobslprh	145	57	[	[	-LRB-
cord-017954-vobslprh	145	58	56	56	CD
cord-017954-vobslprh	145	59	]	]	-RRB-
cord-017954-vobslprh	145	60	,	,	,
cord-017954-vobslprh	145	61	whereas	whereas	IN
cord-017954-vobslprh	145	62	the	the	DT
cord-017954-vobslprh	145	63	axonal	axonal	JJ
cord-017954-vobslprh	145	64	forms	form	NNS
cord-017954-vobslprh	145	65	of	of	IN
cord-017954-vobslprh	145	66	GBS	GBS	NNP
cord-017954-vobslprh	145	67	(	(	-LRB-
cord-017954-vobslprh	145	68	AMAN	AMAN	NNP
cord-017954-vobslprh	145	69	,	,	,
cord-017954-vobslprh	145	70	AMSAN	amsan	NN
cord-017954-vobslprh	145	71	)	)	-RRB-
cord-017954-vobslprh	145	72	usually	usually	RB
cord-017954-vobslprh	145	73	do	do	VBP
cord-017954-vobslprh	145	74	not	not	RB
cord-017954-vobslprh	145	75	include	include	VB
cord-017954-vobslprh	145	76	lymphocyte	lymphocyte	NN
cord-017954-vobslprh	145	77	or	or	CC
cord-017954-vobslprh	145	78	monocyte	monocyte	JJ
cord-017954-vobslprh	145	79	involvement	involvement	NN
cord-017954-vobslprh	145	80	,	,	,
cord-017954-vobslprh	145	81	rather	rather	RB
cord-017954-vobslprh	145	82	Wallerian	wallerian	JJ
cord-017954-vobslprh	145	83	degeneration	degeneration	NN
cord-017954-vobslprh	145	84	as	as	RB
cord-017954-vobslprh	145	85	well	well	RB
cord-017954-vobslprh	145	86	as	as	IN
cord-017954-vobslprh	145	87	complement	complement	NN
cord-017954-vobslprh	145	88	and	and	CC
cord-017954-vobslprh	145	89	anti	anti	JJ
cord-017954-vobslprh	145	90	-	-	JJ
cord-017954-vobslprh	145	91	ganglioside	ganglioside	JJ
cord-017954-vobslprh	145	92	antibodies	antibody	NNS
cord-017954-vobslprh	145	93	that	that	WDT
cord-017954-vobslprh	145	94	directly	directly	RB
cord-017954-vobslprh	145	95	mediate	mediate	VB
cord-017954-vobslprh	145	96	myelin	myelin	JJ
cord-017954-vobslprh	145	97	destruction	destruction	NN
cord-017954-vobslprh	145	98	[	[	-LRB-
cord-017954-vobslprh	145	99	57	57	CD
cord-017954-vobslprh	145	100	]	]	-RRB-
cord-017954-vobslprh	145	101	.	.	.
cord-017954-vobslprh	146	1	Disease	Disease	NNP
cord-017954-vobslprh	146	2	is	be	VBZ
cord-017954-vobslprh	146	3	often	often	RB
cord-017954-vobslprh	146	4	acute	acute	JJ
cord-017954-vobslprh	146	5	and	and	CC
cord-017954-vobslprh	146	6	the	the	DT
cord-017954-vobslprh	146	7	recovery	recovery	NN
cord-017954-vobslprh	146	8	of	of	IN
cord-017954-vobslprh	146	9	motor	motor	NN
cord-017954-vobslprh	146	10	function	function	NN
cord-017954-vobslprh	146	11	is	be	VBZ
cord-017954-vobslprh	146	12	common	common	JJ
cord-017954-vobslprh	146	13	in	in	IN
cord-017954-vobslprh	146	14	approximately	approximately	RB
cord-017954-vobslprh	146	15	60	60	CD
cord-017954-vobslprh	146	16	%	%	NN
cord-017954-vobslprh	146	17	of	of	IN
cord-017954-vobslprh	146	18	GBS	GBS	NNP
cord-017954-vobslprh	146	19	patients	patient	NNS
cord-017954-vobslprh	146	20	.	.	.
cord-017954-vobslprh	147	1	However	however	RB
cord-017954-vobslprh	147	2	,	,	,
cord-017954-vobslprh	147	3	in	in	IN
cord-017954-vobslprh	147	4	other	other	JJ
cord-017954-vobslprh	147	5	cases	case	NNS
cord-017954-vobslprh	147	6	,	,	,
cord-017954-vobslprh	147	7	residual	residual	JJ
cord-017954-vobslprh	147	8	sensory	sensory	JJ
cord-017954-vobslprh	147	9	deficits	deficit	NNS
cord-017954-vobslprh	147	10	remain	remain	VBP
cord-017954-vobslprh	147	11	,	,	,
cord-017954-vobslprh	147	12	and	and	CC
cord-017954-vobslprh	147	13	in	in	IN
cord-017954-vobslprh	147	14	extreme	extreme	JJ
cord-017954-vobslprh	147	15	cases	case	NNS
cord-017954-vobslprh	147	16	,	,	,
cord-017954-vobslprh	147	17	severe	severe	JJ
cord-017954-vobslprh	147	18	alterations	alteration	NNS
cord-017954-vobslprh	147	19	to	to	IN
cord-017954-vobslprh	147	20	the	the	DT
cord-017954-vobslprh	147	21	autonomic	autonomic	JJ
cord-017954-vobslprh	147	22	nervous	nervous	JJ
cord-017954-vobslprh	147	23	system	system	NN
cord-017954-vobslprh	147	24	can	can	MD
cord-017954-vobslprh	147	25	cause	cause	VB
cord-017954-vobslprh	147	26	death	death	NN
cord-017954-vobslprh	147	27	by	by	IN
cord-017954-vobslprh	147	28	respiratory	respiratory	JJ
cord-017954-vobslprh	147	29	failure	failure	NN
cord-017954-vobslprh	147	30	,	,	,
cord-017954-vobslprh	147	31	embolism	embolism	NN
cord-017954-vobslprh	147	32	,	,	,
cord-017954-vobslprh	147	33	or	or	CC
cord-017954-vobslprh	147	34	cardiac	cardiac	JJ
cord-017954-vobslprh	147	35	arrest	arrest	NN
cord-017954-vobslprh	147	36	.	.	.
cord-017954-vobslprh	148	1	Current	current	JJ
cord-017954-vobslprh	148	2	treatment	treatment	NN
cord-017954-vobslprh	148	3	of	of	IN
cord-017954-vobslprh	148	4	GBS	GBS	NNP
cord-017954-vobslprh	148	5	is	be	VBZ
cord-017954-vobslprh	148	6	generally	generally	RB
cord-017954-vobslprh	148	7	nonspecific	nonspecific	JJ
cord-017954-vobslprh	148	8	and	and	CC
cord-017954-vobslprh	148	9	typically	typically	RB
cord-017954-vobslprh	148	10	includes	include	VBZ
cord-017954-vobslprh	148	11	the	the	DT
cord-017954-vobslprh	148	12	administration	administration	NN
cord-017954-vobslprh	148	13	of	of	IN
cord-017954-vobslprh	148	14	intravenous	intravenous	JJ
cord-017954-vobslprh	148	15	immunoglobulins	immunoglobulin	NNS
cord-017954-vobslprh	148	16	or	or	CC
cord-017954-vobslprh	148	17	plasmapheresis	plasmapheresis	NN
cord-017954-vobslprh	148	18	,	,	,
cord-017954-vobslprh	148	19	which	which	WDT
cord-017954-vobslprh	148	20	reduce	reduce	VBP
cord-017954-vobslprh	148	21	the	the	DT
cord-017954-vobslprh	148	22	duration	duration	NN
cord-017954-vobslprh	148	23	to	to	IN
cord-017954-vobslprh	148	24	recovery	recovery	NN
cord-017954-vobslprh	148	25	.	.	.
cord-017954-vobslprh	149	1	However	however	RB
cord-017954-vobslprh	149	2	,	,	,
cord-017954-vobslprh	149	3	neither	neither	DT
cord-017954-vobslprh	149	4	of	of	IN
cord-017954-vobslprh	149	5	these	these	DT
cord-017954-vobslprh	149	6	treatments	treatment	NNS
cord-017954-vobslprh	149	7	is	be	VBZ
cord-017954-vobslprh	149	8	curative	curative	JJ
cord-017954-vobslprh	149	9	,	,	,
cord-017954-vobslprh	149	10	and	and	CC
cord-017954-vobslprh	149	11	therefore	therefore	RB
cord-017954-vobslprh	149	12	,	,	,
cord-017954-vobslprh	149	13	the	the	DT
cord-017954-vobslprh	149	14	use	use	NN
cord-017954-vobslprh	149	15	of	of	IN
cord-017954-vobslprh	149	16	animal	animal	NN
cord-017954-vobslprh	149	17	models	model	NNS
cord-017954-vobslprh	149	18	of	of	IN
cord-017954-vobslprh	149	19	GBS	GBS	NNP
cord-017954-vobslprh	149	20	to	to	TO
cord-017954-vobslprh	149	21	identify	identify	VB
cord-017954-vobslprh	149	22	pathogenic	pathogenic	JJ
cord-017954-vobslprh	149	23	mechanisms	mechanism	NNS
cord-017954-vobslprh	149	24	and	and	CC
cord-017954-vobslprh	149	25	to	to	TO
cord-017954-vobslprh	149	26	test	test	VB
cord-017954-vobslprh	149	27	novel	novel	NN
cord-017954-vobslprh	149	28	treatments	treatment	NNS
cord-017954-vobslprh	149	29	is	be	VBZ
cord-017954-vobslprh	149	30	important	important	JJ
cord-017954-vobslprh	149	31	.	.	.
cord-017954-vobslprh	150	1	Experimental	experimental	JJ
cord-017954-vobslprh	150	2	autoimmune	autoimmune	JJ
cord-017954-vobslprh	150	3	neuritis	neuritis	NN
cord-017954-vobslprh	150	4	(	(	-LRB-
cord-017954-vobslprh	150	5	EAN	EAN	NNP
cord-017954-vobslprh	150	6	)	)	-RRB-
cord-017954-vobslprh	150	7	is	be	VBZ
cord-017954-vobslprh	150	8	a	a	DT
cord-017954-vobslprh	150	9	commonly	commonly	RB
cord-017954-vobslprh	150	10	used	use	VBN
cord-017954-vobslprh	150	11	,	,	,
cord-017954-vobslprh	150	12	robust	robust	JJ
cord-017954-vobslprh	150	13	,	,	,
cord-017954-vobslprh	150	14	and	and	CC
cord-017954-vobslprh	150	15	highly	highly	RB
cord-017954-vobslprh	150	16	predictable	predictable	JJ
cord-017954-vobslprh	150	17	animal	animal	NN
cord-017954-vobslprh	150	18	model	model	NN
cord-017954-vobslprh	150	19	of	of	IN
cord-017954-vobslprh	150	20	GBS	GBS	NNP
cord-017954-vobslprh	150	21	.	.	.
cord-017954-vobslprh	151	1	It	-PRON-	PRP
cord-017954-vobslprh	151	2	was	be	VBD
cord-017954-vobslprh	151	3	originally	originally	RB
cord-017954-vobslprh	151	4	developed	develop	VBN
cord-017954-vobslprh	151	5	in	in	IN
cord-017954-vobslprh	151	6	rabbits	rabbit	NNS
cord-017954-vobslprh	151	7	[	[	-LRB-
cord-017954-vobslprh	151	8	58	58	CD
cord-017954-vobslprh	151	9	]	]	-RRB-
cord-017954-vobslprh	151	10	,	,	,
cord-017954-vobslprh	151	11	but	but	CC
cord-017954-vobslprh	151	12	has	have	VBZ
cord-017954-vobslprh	151	13	since	since	IN
cord-017954-vobslprh	151	14	been	be	VBN
cord-017954-vobslprh	151	15	induced	induce	VBN
cord-017954-vobslprh	151	16	in	in	IN
cord-017954-vobslprh	151	17	a	a	DT
cord-017954-vobslprh	151	18	wide	wide	JJ
cord-017954-vobslprh	151	19	variety	variety	NN
cord-017954-vobslprh	151	20	of	of	IN
cord-017954-vobslprh	151	21	animals	animal	NNS
cord-017954-vobslprh	151	22	including	include	VBG
cord-017954-vobslprh	151	23	rats	rat	NNS
cord-017954-vobslprh	151	24	,	,	,
cord-017954-vobslprh	151	25	mice	mouse	NNS
cord-017954-vobslprh	151	26	,	,	,
cord-017954-vobslprh	151	27	rabbits	rabbit	NNS
cord-017954-vobslprh	151	28	,	,	,
cord-017954-vobslprh	151	29	guinea	guinea	NN
cord-017954-vobslprh	151	30	pigs	pig	NNS
cord-017954-vobslprh	151	31	,	,	,
cord-017954-vobslprh	151	32	and	and	CC
cord-017954-vobslprh	151	33	monkeys	monkey	NNS
cord-017954-vobslprh	151	34	.	.	.
cord-017954-vobslprh	152	1	Disease	Disease	NNP
cord-017954-vobslprh	152	2	is	be	VBZ
cord-017954-vobslprh	152	3	induced	induce	VBN
cord-017954-vobslprh	152	4	by	by	IN
cord-017954-vobslprh	152	5	the	the	DT
cord-017954-vobslprh	152	6	active	active	JJ
cord-017954-vobslprh	152	7	immunization	immunization	NN
cord-017954-vobslprh	152	8	of	of	IN
cord-017954-vobslprh	152	9	susceptible	susceptible	JJ
cord-017954-vobslprh	152	10	animals	animal	NNS
cord-017954-vobslprh	152	11	with	with	IN
cord-017954-vobslprh	152	12	purified	purify	VBN
cord-017954-vobslprh	152	13	whole	whole	JJ
cord-017954-vobslprh	152	14	peripheral	peripheral	JJ
cord-017954-vobslprh	152	15	nerve	nerve	NN
cord-017954-vobslprh	152	16	myelin	myelin	NN
cord-017954-vobslprh	152	17	or	or	CC
cord-017954-vobslprh	152	18	specific	specific	JJ
cord-017954-vobslprh	152	19	myelin	myelin	JJ
cord-017954-vobslprh	152	20	protein	protein	NN
cord-017954-vobslprh	152	21	components	component	NNS
cord-017954-vobslprh	152	22	(	(	-LRB-
cord-017954-vobslprh	152	23	myelin	myelin	JJ
cord-017954-vobslprh	152	24	protein	protein	NN
cord-017954-vobslprh	152	25	2	2	CD
cord-017954-vobslprh	152	26	[	[	-LRB-
cord-017954-vobslprh	152	27	P2	P2	NNP
cord-017954-vobslprh	152	28	]	]	-RRB-
cord-017954-vobslprh	152	29	,	,	,
cord-017954-vobslprh	152	30	myelin	myelin	NN
cord-017954-vobslprh	152	31	protein	protein	NN
cord-017954-vobslprh	152	32	zero	zero	CD
cord-017954-vobslprh	152	33	[	[	-LRB-
cord-017954-vobslprh	152	34	p0	p0	NN
cord-017954-vobslprh	152	35	]	]	-RRB-
cord-017954-vobslprh	152	36	)	)	-RRB-
cord-017954-vobslprh	152	37	in	in	IN
cord-017954-vobslprh	152	38	complete	complete	JJ
cord-017954-vobslprh	152	39	Freund	Freund	NNP
cord-017954-vobslprh	152	40	's	's	POS
cord-017954-vobslprh	152	41	adjuvant	adjuvant	NN
cord-017954-vobslprh	152	42	[	[	-LRB-
cord-017954-vobslprh	152	43	58	58	CD
cord-017954-vobslprh	152	44	]	]	-RRB-
cord-017954-vobslprh	152	45	[	[	-LRB-
cord-017954-vobslprh	152	46	59	59	CD
cord-017954-vobslprh	152	47	]	]	-RRB-
cord-017954-vobslprh	152	48	[	[	-LRB-
cord-017954-vobslprh	152	49	60	60	CD
cord-017954-vobslprh	152	50	]	]	-RRB-
cord-017954-vobslprh	152	51	.	.	.
cord-017954-vobslprh	153	1	EAN	EAN	NNP
cord-017954-vobslprh	153	2	in	in	IN
cord-017954-vobslprh	153	3	rats	rat	NNS
cord-017954-vobslprh	153	4	and	and	CC
cord-017954-vobslprh	153	5	mice	mouse	NNS
cord-017954-vobslprh	153	6	is	be	VBZ
cord-017954-vobslprh	153	7	a	a	DT
cord-017954-vobslprh	153	8	monophasic	monophasic	JJ
cord-017954-vobslprh	153	9	acute	acute	JJ
cord-017954-vobslprh	153	10	demyelinating	demyelinate	VBG
cord-017954-vobslprh	153	11	inflammatory	inflammatory	JJ
cord-017954-vobslprh	153	12	disease	disease	NN
cord-017954-vobslprh	153	13	of	of	IN
cord-017954-vobslprh	153	14	the	the	DT
cord-017954-vobslprh	153	15	peripheral	peripheral	JJ
cord-017954-vobslprh	153	16	nervous	nervous	JJ
cord-017954-vobslprh	153	17	system	system	NN
cord-017954-vobslprh	153	18	[	[	-LRB-
cord-017954-vobslprh	153	19	58	58	CD
cord-017954-vobslprh	153	20	]	]	-RRB-
cord-017954-vobslprh	153	21	with	with	IN
cord-017954-vobslprh	153	22	many	many	JJ
cord-017954-vobslprh	153	23	similarities	similarity	NNS
cord-017954-vobslprh	153	24	to	to	IN
cord-017954-vobslprh	153	25	GBS	GBS	NNP
cord-017954-vobslprh	153	26	including	include	VBG
cord-017954-vobslprh	153	27	clinical	clinical	JJ
cord-017954-vobslprh	153	28	,	,	,
cord-017954-vobslprh	153	29	immunological	immunological	JJ
cord-017954-vobslprh	153	30	,	,	,
cord-017954-vobslprh	153	31	and	and	CC
cord-017954-vobslprh	153	32	morphological	morphological	JJ
cord-017954-vobslprh	153	33	characteristics	characteristic	NNS
cord-017954-vobslprh	153	34	.	.	.
cord-017954-vobslprh	154	1	In	in	IN
cord-017954-vobslprh	154	2	rats	rat	NNS
cord-017954-vobslprh	154	3	,	,	,
cord-017954-vobslprh	154	4	onset	onset	NN
cord-017954-vobslprh	154	5	of	of	IN
cord-017954-vobslprh	154	6	disease	disease	NN
cord-017954-vobslprh	154	7	is	be	VBZ
cord-017954-vobslprh	154	8	observed	observe	VBN
cord-017954-vobslprh	154	9	at	at	IN
cord-017954-vobslprh	154	10	12	12	CD
cord-017954-vobslprh	154	11	-	-	SYM
cord-017954-vobslprh	154	12	13	13	CD
cord-017954-vobslprh	154	13	post	post	NN
cord-017954-vobslprh	154	14	-	-	NN
cord-017954-vobslprh	154	15	immunization	immunization	NN
cord-017954-vobslprh	154	16	with	with	IN
cord-017954-vobslprh	154	17	a	a	DT
cord-017954-vobslprh	154	18	peak	peak	NN
cord-017954-vobslprh	154	19	of	of	IN
cord-017954-vobslprh	154	20	disease	disease	NN
cord-017954-vobslprh	154	21	severity	severity	NN
cord-017954-vobslprh	154	22	at	at	IN
cord-017954-vobslprh	154	23	day	day	NN
cord-017954-vobslprh	154	24	16	16	CD
cord-017954-vobslprh	154	25	.	.	.
cord-017954-vobslprh	155	1	Clinical	clinical	JJ
cord-017954-vobslprh	155	2	disease	disease	NN
cord-017954-vobslprh	155	3	is	be	VBZ
cord-017954-vobslprh	155	4	characterized	characterize	VBN
cord-017954-vobslprh	155	5	by	by	IN
cord-017954-vobslprh	155	6	tail	tail	NN
cord-017954-vobslprh	155	7	and	and	CC
cord-017954-vobslprh	155	8	limb	limb	NN
cord-017954-vobslprh	155	9	weakness	weakness	NN
cord-017954-vobslprh	155	10	,	,	,
cord-017954-vobslprh	155	11	and	and	CC
cord-017954-vobslprh	155	12	histopathological	histopathological	JJ
cord-017954-vobslprh	155	13	analyses	analysis	NNS
cord-017954-vobslprh	155	14	have	have	VBP
cord-017954-vobslprh	155	15	shown	show	VBN
cord-017954-vobslprh	155	16	the	the	DT
cord-017954-vobslprh	155	17	presence	presence	NN
cord-017954-vobslprh	155	18	of	of	IN
cord-017954-vobslprh	155	19	nerve	nerve	NN
cord-017954-vobslprh	155	20	oedema	oedema	NN
cord-017954-vobslprh	155	21	and	and	CC
cord-017954-vobslprh	155	22	demyelinated	demyelinate	VBD
cord-017954-vobslprh	155	23	peripheral	peripheral	JJ
cord-017954-vobslprh	155	24	nerves	nerve	NNS
cord-017954-vobslprh	155	25	accompanied	accompany	VBN
cord-017954-vobslprh	155	26	by	by	IN
cord-017954-vobslprh	155	27	the	the	DT
cord-017954-vobslprh	155	28	infiltration	infiltration	NN
cord-017954-vobslprh	155	29	of	of	IN
cord-017954-vobslprh	155	30	inflammatory	inflammatory	JJ
cord-017954-vobslprh	155	31	cells	cell	NNS
cord-017954-vobslprh	155	32	,	,	,
cord-017954-vobslprh	155	33	features	feature	VBZ
cord-017954-vobslprh	155	34	which	which	WDT
cord-017954-vobslprh	155	35	are	be	VBP
cord-017954-vobslprh	155	36	present	present	JJ
cord-017954-vobslprh	155	37	in	in	IN
cord-017954-vobslprh	155	38	GBS	GBS	NNP
cord-017954-vobslprh	155	39	.	.	.
cord-017954-vobslprh	156	1	Symptoms	symptom	NNS
cord-017954-vobslprh	156	2	are	be	VBP
cord-017954-vobslprh	156	3	likely	likely	JJ
cord-017954-vobslprh	156	4	to	to	TO
cord-017954-vobslprh	156	5	be	be	VB
cord-017954-vobslprh	156	6	caused	cause	VBN
cord-017954-vobslprh	156	7	by	by	IN
cord-017954-vobslprh	156	8	a	a	DT
cord-017954-vobslprh	156	9	combination	combination	NN
cord-017954-vobslprh	156	10	of	of	IN
cord-017954-vobslprh	156	11	nerve	nerve	NN
cord-017954-vobslprh	156	12	conduction	conduction	NN
cord-017954-vobslprh	156	13	block	block	NN
cord-017954-vobslprh	156	14	and	and	CC
cord-017954-vobslprh	156	15	the	the	DT
cord-017954-vobslprh	156	16	effects	effect	NNS
cord-017954-vobslprh	156	17	of	of	IN
cord-017954-vobslprh	156	18	demyelination	demyelination	NN
cord-017954-vobslprh	156	19	.	.	.
cord-017954-vobslprh	157	1	During	during	IN
cord-017954-vobslprh	157	2	the	the	DT
cord-017954-vobslprh	157	3	effector	effector	JJ
cord-017954-vobslprh	157	4	phase	phase	NN
cord-017954-vobslprh	157	5	of	of	IN
cord-017954-vobslprh	157	6	EAN	EAN	NNP
cord-017954-vobslprh	157	7	disease	disease	NN
cord-017954-vobslprh	157	8	,	,	,
cord-017954-vobslprh	157	9	typical	typical	JJ
cord-017954-vobslprh	157	10	pro	pro	JJ
cord-017954-vobslprh	157	11	-	-	JJ
cord-017954-vobslprh	157	12	inflammatory	inflammatory	JJ
cord-017954-vobslprh	157	13	components	component	NNS
cord-017954-vobslprh	157	14	including	include	VBG
cord-017954-vobslprh	157	15	chemokines	chemokine	NNS
cord-017954-vobslprh	157	16	(	(	-LRB-
cord-017954-vobslprh	157	17	MIP-1α	MIP-1α	NNP
cord-017954-vobslprh	157	18	and	and	CC
cord-017954-vobslprh	157	19	MIP-1β	MIP-1β	NNP
cord-017954-vobslprh	157	20	,	,	,
cord-017954-vobslprh	157	21	MCP-1	MCP-1	NNP
cord-017954-vobslprh	157	22	,	,	,
cord-017954-vobslprh	157	23	RANTES	RANTES	NNP
cord-017954-vobslprh	157	24	,	,	,
cord-017954-vobslprh	157	25	and	and	CC
cord-017954-vobslprh	157	26	IP-10	IP-10	NNP
cord-017954-vobslprh	157	27	)	)	-RRB-
cord-017954-vobslprh	157	28	(	(	-LRB-
cord-017954-vobslprh	157	29	reviewed	review	VBN
cord-017954-vobslprh	157	30	by	by	IN
cord-017954-vobslprh	157	31	Fujioka	Fujioka	NNP
cord-017954-vobslprh	157	32	1999	1999	CD
cord-017954-vobslprh	157	33	)	)	-RRB-
cord-017954-vobslprh	157	34	[	[	-LRB-
cord-017954-vobslprh	157	35	61	61	CD
cord-017954-vobslprh	157	36	,	,	,
cord-017954-vobslprh	157	37	62	62	CD
cord-017954-vobslprh	157	38	]	]	-RRB-
cord-017954-vobslprh	157	39	,	,	,
cord-017954-vobslprh	157	40	cytokines	cytokine	NNS
cord-017954-vobslprh	157	41	(	(	-LRB-
cord-017954-vobslprh	157	42	reviewed	review	VBN
cord-017954-vobslprh	157	43	by	by	IN
cord-017954-vobslprh	157	44	Zhu	Zhu	NNP
cord-017954-vobslprh	157	45	1998	1998	CD
cord-017954-vobslprh	157	46	)	)	-RRB-
cord-017954-vobslprh	157	47	[	[	-LRB-
cord-017954-vobslprh	157	48	63	63	CD
cord-017954-vobslprh	157	49	]	]	-RRB-
cord-017954-vobslprh	157	50	,	,	,
cord-017954-vobslprh	157	51	and	and	CC
cord-017954-vobslprh	157	52	adhesion	adhesion	NN
cord-017954-vobslprh	157	53	molecules	molecule	NNS
cord-017954-vobslprh	157	54	(	(	-LRB-
cord-017954-vobslprh	157	55	VCAM-1	VCAM-1	NNP
cord-017954-vobslprh	157	56	)	)	-RRB-
cord-017954-vobslprh	157	57	[	[	-LRB-
cord-017954-vobslprh	157	58	64	64	CD
cord-017954-vobslprh	157	59	]	]	-RRB-
cord-017954-vobslprh	157	60	have	have	VBP
cord-017954-vobslprh	157	61	been	be	VBN
cord-017954-vobslprh	157	62	shown	show	VBN
cord-017954-vobslprh	157	63	to	to	TO
cord-017954-vobslprh	157	64	be	be	VB
cord-017954-vobslprh	157	65	upregulated	upregulate	VBN
cord-017954-vobslprh	157	66	.	.	.
cord-017954-vobslprh	158	1	Th1-type	Th1-type	NNP
cord-017954-vobslprh	158	2	cytokines	cytokine	NNS
cord-017954-vobslprh	158	3	might	may	MD
cord-017954-vobslprh	158	4	mediate	mediate	VB
cord-017954-vobslprh	158	5	the	the	DT
cord-017954-vobslprh	158	6	demyelination	demyelination	NN
cord-017954-vobslprh	158	7	of	of	IN
cord-017954-vobslprh	158	8	peripheral	peripheral	JJ
cord-017954-vobslprh	158	9	nerves	nerve	NNS
cord-017954-vobslprh	158	10	as	as	IN
cord-017954-vobslprh	158	11	evidence	evidence	NN
cord-017954-vobslprh	158	12	shows	show	VBZ
cord-017954-vobslprh	158	13	that	that	IN
cord-017954-vobslprh	158	14	the	the	DT
cord-017954-vobslprh	158	15	addition	addition	NN
cord-017954-vobslprh	158	16	of	of	IN
cord-017954-vobslprh	158	17	IFN	IFN	NNP
cord-017954-vobslprh	158	18	-	-	HYPH
cord-017954-vobslprh	158	19	γ	γ	NNP
cord-017954-vobslprh	158	20	can	can	MD
cord-017954-vobslprh	158	21	enhance	enhance	VB
cord-017954-vobslprh	158	22	EAN	EAN	NNP
cord-017954-vobslprh	158	23	,	,	,
cord-017954-vobslprh	158	24	whereas	whereas	IN
cord-017954-vobslprh	158	25	blockade	blockade	NN
cord-017954-vobslprh	158	26	of	of	IN
cord-017954-vobslprh	158	27	IFN	IFN	NNP
cord-017954-vobslprh	158	28	-	-	HYPH
cord-017954-vobslprh	158	29	γ	γ	NNP
cord-017954-vobslprh	158	30	with	with	IN
cord-017954-vobslprh	158	31	neutralizing	neutralize	VBG
cord-017954-vobslprh	158	32	antibodies	antibody	NNS
cord-017954-vobslprh	158	33	can	can	MD
cord-017954-vobslprh	158	34	ameliorate	ameliorate	VB
cord-017954-vobslprh	158	35	EAN	EAN	NNP
cord-017954-vobslprh	158	36	symptoms	symptom	NNS
cord-017954-vobslprh	158	37	and	and	CC
cord-017954-vobslprh	158	38	disease	disease	NN
cord-017954-vobslprh	158	39	course	course	NN
cord-017954-vobslprh	158	40	[	[	-LRB-
cord-017954-vobslprh	158	41	65	65	CD
cord-017954-vobslprh	158	42	]	]	-RRB-
cord-017954-vobslprh	158	43	.	.	.
cord-017954-vobslprh	159	1	EAN	EAN	NNP
cord-017954-vobslprh	159	2	mouse	mouse	NN
cord-017954-vobslprh	159	3	models	model	NNS
cord-017954-vobslprh	159	4	with	with	IN
cord-017954-vobslprh	159	5	severe	severe	JJ
cord-017954-vobslprh	159	6	clinical	clinical	JJ
cord-017954-vobslprh	159	7	symptoms	symptom	NNS
cord-017954-vobslprh	159	8	and	and	CC
cord-017954-vobslprh	159	9	pathological	pathological	JJ
cord-017954-vobslprh	159	10	features	feature	NNS
cord-017954-vobslprh	159	11	similar	similar	JJ
cord-017954-vobslprh	159	12	to	to	IN
cord-017954-vobslprh	159	13	rat	rat	NN
cord-017954-vobslprh	159	14	EAN	EAN	NNP
cord-017954-vobslprh	159	15	have	have	VBP
cord-017954-vobslprh	159	16	also	also	RB
cord-017954-vobslprh	159	17	been	be	VBN
cord-017954-vobslprh	159	18	reported	report	VBN
cord-017954-vobslprh	159	19	.	.	.
cord-017954-vobslprh	160	1	An	an	DT
cord-017954-vobslprh	160	2	early	early	JJ
cord-017954-vobslprh	160	3	study	study	NN
cord-017954-vobslprh	160	4	reported	report	VBD
cord-017954-vobslprh	160	5	the	the	DT
cord-017954-vobslprh	160	6	induction	induction	NN
cord-017954-vobslprh	160	7	of	of	IN
cord-017954-vobslprh	160	8	EAN	EAN	NNP
cord-017954-vobslprh	160	9	SJL	SJL	NNP
cord-017954-vobslprh	160	10	/	/	SYM
cord-017954-vobslprh	160	11	J	J	NNP
cord-017954-vobslprh	160	12	mice	mouse	NNS
cord-017954-vobslprh	160	13	,	,	,
cord-017954-vobslprh	160	14	which	which	WDT
cord-017954-vobslprh	160	15	showed	show	VBD
cord-017954-vobslprh	160	16	subclinical	subclinical	JJ
cord-017954-vobslprh	160	17	damage	damage	NN
cord-017954-vobslprh	160	18	to	to	IN
cord-017954-vobslprh	160	19	peripheral	peripheral	JJ
cord-017954-vobslprh	160	20	nerve	nerve	NN
cord-017954-vobslprh	160	21	myelin	myelin	NN
cord-017954-vobslprh	160	22	but	but	CC
cord-017954-vobslprh	160	23	without	without	IN
cord-017954-vobslprh	160	24	clinical	clinical	JJ
cord-017954-vobslprh	160	25	symptoms	symptom	NNS
cord-017954-vobslprh	160	26	,	,	,
cord-017954-vobslprh	160	27	in	in	IN
cord-017954-vobslprh	160	28	contrast	contrast	NN
cord-017954-vobslprh	160	29	to	to	IN
cord-017954-vobslprh	160	30	EAN	EAN	NNP
cord-017954-vobslprh	160	31	Lewis	Lewis	NNP
cord-017954-vobslprh	160	32	rats	rat	NNS
cord-017954-vobslprh	160	33	,	,	,
cord-017954-vobslprh	160	34	that	that	WDT
cord-017954-vobslprh	160	35	developed	develop	VBD
cord-017954-vobslprh	160	36	typical	typical	JJ
cord-017954-vobslprh	160	37	hind	hind	JJ
cord-017954-vobslprh	160	38	-	-	HYPH
cord-017954-vobslprh	160	39	limb	limb	NN
cord-017954-vobslprh	160	40	weakness	weakness	NN
cord-017954-vobslprh	160	41	and	and	CC
cord-017954-vobslprh	160	42	histopathology	histopathology	NN
cord-017954-vobslprh	160	43	of	of	IN
cord-017954-vobslprh	160	44	the	the	DT
cord-017954-vobslprh	160	45	peripheral	peripheral	JJ
cord-017954-vobslprh	160	46	nervous	nervous	JJ
cord-017954-vobslprh	160	47	system	system	NN
cord-017954-vobslprh	160	48	[	[	-LRB-
cord-017954-vobslprh	160	49	66	66	CD
cord-017954-vobslprh	160	50	]	]	-RRB-
cord-017954-vobslprh	160	51	.	.	.
cord-017954-vobslprh	161	1	A	a	DT
cord-017954-vobslprh	161	2	subsequent	subsequent	JJ
cord-017954-vobslprh	161	3	study	study	NN
cord-017954-vobslprh	161	4	demonstrated	demonstrate	VBD
cord-017954-vobslprh	161	5	that	that	IN
cord-017954-vobslprh	161	6	the	the	DT
cord-017954-vobslprh	161	7	addition	addition	NN
cord-017954-vobslprh	161	8	of	of	IN
cord-017954-vobslprh	161	9	pertussis	pertussis	NN
cord-017954-vobslprh	161	10	toxin	toxin	NN
cord-017954-vobslprh	161	11	to	to	IN
cord-017954-vobslprh	161	12	SJL	SJL	NNP
cord-017954-vobslprh	161	13	/	/	SYM
cord-017954-vobslprh	161	14	J	J	NNP
cord-017954-vobslprh	161	15	mice	mouse	NNS
cord-017954-vobslprh	161	16	immunized	immunize	VBN
cord-017954-vobslprh	161	17	with	with	IN
cord-017954-vobslprh	161	18	bovine	bovine	JJ
cord-017954-vobslprh	161	19	peripheral	peripheral	JJ
cord-017954-vobslprh	161	20	nerve	nerve	NN
cord-017954-vobslprh	161	21	myelin	myelin	NN
cord-017954-vobslprh	161	22	in	in	IN
cord-017954-vobslprh	161	23	complete	complete	JJ
cord-017954-vobslprh	161	24	Freund	Freund	NNP
cord-017954-vobslprh	161	25	's	's	POS
cord-017954-vobslprh	161	26	adjuvant	adjuvant	NN
cord-017954-vobslprh	161	27	enhanced	enhance	VBD
cord-017954-vobslprh	161	28	the	the	DT
cord-017954-vobslprh	161	29	mild	mild	JJ
cord-017954-vobslprh	161	30	disease	disease	NN
cord-017954-vobslprh	161	31	seen	see	VBN
cord-017954-vobslprh	161	32	in	in	IN
cord-017954-vobslprh	161	33	the	the	DT
cord-017954-vobslprh	161	34	absence	absence	NN
cord-017954-vobslprh	161	35	of	of	IN
cord-017954-vobslprh	161	36	pertussis	pertussis	NN
cord-017954-vobslprh	161	37	toxin	toxin	NN
cord-017954-vobslprh	161	38	[	[	-LRB-
cord-017954-vobslprh	161	39	67	67	CD
cord-017954-vobslprh	161	40	]	]	-RRB-
cord-017954-vobslprh	161	41	.	.	.
cord-017954-vobslprh	162	1	When	when	WRB
cord-017954-vobslprh	162	2	immunized	immunize	VBN
cord-017954-vobslprh	162	3	mice	mouse	NNS
cord-017954-vobslprh	162	4	with	with	IN
cord-017954-vobslprh	162	5	pertussis	pertussis	NN
cord-017954-vobslprh	162	6	toxin	toxin	NN
cord-017954-vobslprh	162	7	were	be	VBD
cord-017954-vobslprh	162	8	treated	treat	VBN
cord-017954-vobslprh	162	9	with	with	IN
cord-017954-vobslprh	162	10	recombinant	recombinant	JJ
cord-017954-vobslprh	162	11	mouse	mouse	NN
cord-017954-vobslprh	162	12	IL-12	IL-12	NNP
cord-017954-vobslprh	162	13	,	,	,
cord-017954-vobslprh	162	14	the	the	DT
cord-017954-vobslprh	162	15	disease	disease	NN
cord-017954-vobslprh	162	16	course	course	NN
cord-017954-vobslprh	162	17	duration	duration	NN
cord-017954-vobslprh	162	18	was	be	VBD
cord-017954-vobslprh	162	19	prolonged	prolong	VBN
cord-017954-vobslprh	162	20	and	and	CC
cord-017954-vobslprh	162	21	recovery	recovery	NN
cord-017954-vobslprh	162	22	was	be	VBD
cord-017954-vobslprh	162	23	delayed	delay	VBN
cord-017954-vobslprh	162	24	.	.	.
cord-017954-vobslprh	163	1	Histological	Histological	NNP
cord-017954-vobslprh	163	2	analysis	analysis	NN
cord-017954-vobslprh	163	3	demonstrated	demonstrate	VBD
cord-017954-vobslprh	163	4	severe	severe	JJ
cord-017954-vobslprh	163	5	demyelination	demyelination	NN
cord-017954-vobslprh	163	6	of	of	IN
cord-017954-vobslprh	163	7	the	the	DT
cord-017954-vobslprh	163	8	caudae	caudae	NNP
cord-017954-vobslprh	163	9	equinae	equinae	NNP
cord-017954-vobslprh	163	10	and	and	CC
cord-017954-vobslprh	163	11	sciatic	sciatic	NN
cord-017954-vobslprh	163	12	nerves	nerve	NNS
cord-017954-vobslprh	163	13	during	during	IN
cord-017954-vobslprh	163	14	the	the	DT
cord-017954-vobslprh	163	15	recovery	recovery	NN
cord-017954-vobslprh	163	16	stage	stage	NN
cord-017954-vobslprh	163	17	as	as	RB
cord-017954-vobslprh	163	18	well	well	RB
cord-017954-vobslprh	163	19	as	as	IN
cord-017954-vobslprh	163	20	mononuclear	mononuclear	JJ
cord-017954-vobslprh	163	21	cell	cell	NN
cord-017954-vobslprh	163	22	infiltration	infiltration	NN
cord-017954-vobslprh	163	23	.	.	.
cord-017954-vobslprh	164	1	Of	of	IN
cord-017954-vobslprh	164	2	note	note	NN
cord-017954-vobslprh	164	3	,	,	,
cord-017954-vobslprh	164	4	although	although	IN
cord-017954-vobslprh	164	5	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	164	6	mice	mouse	NNS
cord-017954-vobslprh	164	7	were	be	VBD
cord-017954-vobslprh	164	8	initially	initially	RB
cord-017954-vobslprh	164	9	thought	think	VBN
cord-017954-vobslprh	164	10	to	to	TO
cord-017954-vobslprh	164	11	be	be	VB
cord-017954-vobslprh	164	12	resistant	resistant	JJ
cord-017954-vobslprh	164	13	to	to	IN
cord-017954-vobslprh	164	14	EAN	EAN	NNP
cord-017954-vobslprh	164	15	induction	induction	NN
cord-017954-vobslprh	164	16	,	,	,
cord-017954-vobslprh	164	17	immunization	immunization	NN
cord-017954-vobslprh	164	18	of	of	IN
cord-017954-vobslprh	164	19	male	male	NN
cord-017954-vobslprh	164	20	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	164	21	mice	mouse	NNS
cord-017954-vobslprh	164	22	with	with	IN
cord-017954-vobslprh	164	23	a	a	DT
cord-017954-vobslprh	164	24	synthetic	synthetic	JJ
cord-017954-vobslprh	164	25	P0	p0	NN
cord-017954-vobslprh	164	26	180	180	CD
cord-017954-vobslprh	164	27	-	-	SYM
cord-017954-vobslprh	164	28	199	199	CD
cord-017954-vobslprh	164	29	peptide	peptide	NN
cord-017954-vobslprh	164	30	induced	induce	VBD
cord-017954-vobslprh	164	31	the	the	DT
cord-017954-vobslprh	164	32	clinical	clinical	JJ
cord-017954-vobslprh	164	33	and	and	CC
cord-017954-vobslprh	164	34	pathological	pathological	JJ
cord-017954-vobslprh	164	35	characteristics	characteristic	NNS
cord-017954-vobslprh	164	36	of	of	IN
cord-017954-vobslprh	164	37	acute	acute	JJ
cord-017954-vobslprh	164	38	monophasic	monophasic	JJ
cord-017954-vobslprh	164	39	EAN	EAN	NNP
cord-017954-vobslprh	164	40	[	[	-LRB-
cord-017954-vobslprh	164	41	68	68	CD
cord-017954-vobslprh	164	42	]	]	-RRB-
cord-017954-vobslprh	164	43	.	.	.
cord-017954-vobslprh	165	1	As	as	IN
cord-017954-vobslprh	165	2	previously	previously	RB
cord-017954-vobslprh	165	3	shown	show	VBN
cord-017954-vobslprh	165	4	,	,	,
cord-017954-vobslprh	165	5	the	the	DT
cord-017954-vobslprh	165	6	addition	addition	NN
cord-017954-vobslprh	165	7	of	of	IN
cord-017954-vobslprh	165	8	intravenously	intravenously	RB
cord-017954-vobslprh	165	9	administrated	administrate	VBN
cord-017954-vobslprh	165	10	pertussis	pertussis	NN
cord-017954-vobslprh	165	11	toxin	toxin	NN
cord-017954-vobslprh	165	12	increased	increase	VBD
cord-017954-vobslprh	165	13	the	the	DT
cord-017954-vobslprh	165	14	incidence	incidence	NN
cord-017954-vobslprh	165	15	of	of	IN
cord-017954-vobslprh	165	16	EAN	EAN	NNP
cord-017954-vobslprh	165	17	and	and	CC
cord-017954-vobslprh	165	18	enhanced	enhanced	JJ
cord-017954-vobslprh	165	19	inflammation	inflammation	NN
cord-017954-vobslprh	165	20	and	and	CC
cord-017954-vobslprh	165	21	demyelination	demyelination	NN
cord-017954-vobslprh	165	22	of	of	IN
cord-017954-vobslprh	165	23	peripheral	peripheral	JJ
cord-017954-vobslprh	165	24	nerves	nerve	NNS
cord-017954-vobslprh	165	25	.	.	.
cord-017954-vobslprh	166	1	Similar	similar	JJ
cord-017954-vobslprh	166	2	to	to	IN
cord-017954-vobslprh	166	3	that	that	DT
cord-017954-vobslprh	166	4	seen	see	VBN
cord-017954-vobslprh	166	5	for	for	IN
cord-017954-vobslprh	166	6	EAE	EAE	NNP
cord-017954-vobslprh	166	7	,	,	,
cord-017954-vobslprh	166	8	in	in	IN
cord-017954-vobslprh	166	9	addition	addition	NN
cord-017954-vobslprh	166	10	to	to	IN
cord-017954-vobslprh	166	11	immunization	immunization	NN
cord-017954-vobslprh	166	12	models	model	NNS
cord-017954-vobslprh	166	13	of	of	IN
cord-017954-vobslprh	166	14	EAN	EAN	NNP
cord-017954-vobslprh	166	15	,	,	,
cord-017954-vobslprh	166	16	adoptive	adoptive	JJ
cord-017954-vobslprh	166	17	transfer	transfer	NN
cord-017954-vobslprh	166	18	models	model	NNS
cord-017954-vobslprh	166	19	of	of	IN
cord-017954-vobslprh	166	20	EAN	EAN	NNP
cord-017954-vobslprh	166	21	have	have	VBP
cord-017954-vobslprh	166	22	been	be	VBN
cord-017954-vobslprh	166	23	reported	report	VBN
cord-017954-vobslprh	166	24	.	.	.
cord-017954-vobslprh	167	1	P2-and	p2-and	NN
cord-017954-vobslprh	168	1	P0-specific	p0-specific	JJ
cord-017954-vobslprh	168	2	CD4þ	CD4þ	NNP
cord-017954-vobslprh	168	3	T	T	NNP
cord-017954-vobslprh	168	4	cell	cell	NN
cord-017954-vobslprh	168	5	lines	line	NNS
cord-017954-vobslprh	168	6	have	have	VBP
cord-017954-vobslprh	168	7	been	be	VBN
cord-017954-vobslprh	168	8	shown	show	VBN
cord-017954-vobslprh	168	9	to	to	TO
cord-017954-vobslprh	168	10	transfer	transfer	VB
cord-017954-vobslprh	168	11	histopathologically	histopathologically	RB
cord-017954-vobslprh	168	12	similar	similar	JJ
cord-017954-vobslprh	168	13	EAN	EAN	NNP
cord-017954-vobslprh	168	14	to	to	IN
cord-017954-vobslprh	168	15	naïve	naïve	JJ
cord-017954-vobslprh	168	16	syngeneic	syngeneic	NNS
cord-017954-vobslprh	168	17	Lewis	Lewis	NNP
cord-017954-vobslprh	168	18	rat	rat	NN
cord-017954-vobslprh	168	19	recipients	recipient	NNS
cord-017954-vobslprh	168	20	when	when	WRB
cord-017954-vobslprh	168	21	injected	inject	VBN
cord-017954-vobslprh	168	22	intravenously	intravenously	RB
cord-017954-vobslprh	168	23	[	[	-LRB-
cord-017954-vobslprh	168	24	69	69	CD
cord-017954-vobslprh	168	25	]	]	-RRB-
cord-017954-vobslprh	168	26	[	[	-LRB-
cord-017954-vobslprh	168	27	70	70	CD
cord-017954-vobslprh	168	28	]	]	-RRB-
cord-017954-vobslprh	168	29	[	[	-LRB-
cord-017954-vobslprh	168	30	71	71	CD
cord-017954-vobslprh	168	31	]	]	-RRB-
cord-017954-vobslprh	168	32	.	.	.
cord-017954-vobslprh	169	1	However	however	RB
cord-017954-vobslprh	169	2	,	,	,
cord-017954-vobslprh	169	3	the	the	DT
cord-017954-vobslprh	169	4	onset	onset	NN
cord-017954-vobslprh	169	5	of	of	IN
cord-017954-vobslprh	169	6	disease	disease	NN
cord-017954-vobslprh	169	7	was	be	VBD
cord-017954-vobslprh	169	8	earlier	early	RBR
cord-017954-vobslprh	169	9	(	(	-LRB-
cord-017954-vobslprh	169	10	day	day	NN
cord-017954-vobslprh	169	11	7	7	CD
cord-017954-vobslprh	169	12	)	)	-RRB-
cord-017954-vobslprh	169	13	in	in	IN
cord-017954-vobslprh	169	14	a	a	DT
cord-017954-vobslprh	169	15	P2-adoptive	P2-adoptive	NNP
cord-017954-vobslprh	169	16	transfer	transfer	NN
cord-017954-vobslprh	169	17	EAN	EAN	NNP
cord-017954-vobslprh	169	18	model	model	NN
cord-017954-vobslprh	169	19	compared	compare	VBN
cord-017954-vobslprh	169	20	with	with	IN
cord-017954-vobslprh	169	21	active	active	JJ
cord-017954-vobslprh	169	22	immunization	immunization	NN
cord-017954-vobslprh	169	23	EAN	EAN	NNP
cord-017954-vobslprh	169	24	models	model	NNS
cord-017954-vobslprh	169	25	(	(	-LRB-
cord-017954-vobslprh	169	26	day	day	NN
cord-017954-vobslprh	169	27	12	12	CD
cord-017954-vobslprh	169	28	-	-	SYM
cord-017954-vobslprh	169	29	13	13	CD
cord-017954-vobslprh	169	30	)	)	-RRB-
cord-017954-vobslprh	169	31	.	.	.
cord-017954-vobslprh	170	1	Although	although	IN
cord-017954-vobslprh	170	2	EAN	EAN	NNP
cord-017954-vobslprh	170	3	is	be	VBZ
cord-017954-vobslprh	170	4	a	a	DT
cord-017954-vobslprh	170	5	robust	robust	JJ
cord-017954-vobslprh	170	6	,	,	,
cord-017954-vobslprh	170	7	reproducible	reproducible	JJ
cord-017954-vobslprh	170	8	model	model	NN
cord-017954-vobslprh	170	9	of	of	IN
cord-017954-vobslprh	170	10	neuritis	neuritis	NN
cord-017954-vobslprh	170	11	,	,	,
cord-017954-vobslprh	170	12	sharing	share	VBG
cord-017954-vobslprh	170	13	many	many	JJ
cord-017954-vobslprh	170	14	pathological	pathological	JJ
cord-017954-vobslprh	170	15	and	and	CC
cord-017954-vobslprh	170	16	clinical	clinical	JJ
cord-017954-vobslprh	170	17	features	feature	NNS
cord-017954-vobslprh	170	18	with	with	IN
cord-017954-vobslprh	170	19	GBS	GBS	NNP
cord-017954-vobslprh	170	20	,	,	,
cord-017954-vobslprh	170	21	one	one	CD
cord-017954-vobslprh	170	22	critical	critical	JJ
cord-017954-vobslprh	170	23	disadvantage	disadvantage	NN
cord-017954-vobslprh	170	24	is	be	VBZ
cord-017954-vobslprh	170	25	that	that	IN
cord-017954-vobslprh	170	26	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	170	27	jejuni	jejuni	NNP
cord-017954-vobslprh	170	28	infection	infection	NN
cord-017954-vobslprh	170	29	,	,	,
cord-017954-vobslprh	170	30	which	which	WDT
cord-017954-vobslprh	170	31	is	be	VBZ
cord-017954-vobslprh	170	32	thought	think	VBN
cord-017954-vobslprh	170	33	to	to	TO
cord-017954-vobslprh	170	34	be	be	VB
cord-017954-vobslprh	170	35	involved	involve	VBN
cord-017954-vobslprh	170	36	in	in	IN
cord-017954-vobslprh	170	37	a	a	DT
cord-017954-vobslprh	170	38	high	high	JJ
cord-017954-vobslprh	170	39	percentage	percentage	NN
cord-017954-vobslprh	170	40	of	of	IN
cord-017954-vobslprh	170	41	human	human	JJ
cord-017954-vobslprh	170	42	cases	case	NNS
cord-017954-vobslprh	170	43	of	of	IN
cord-017954-vobslprh	170	44	GBS	GBS	NNP
cord-017954-vobslprh	170	45	,	,	,
cord-017954-vobslprh	170	46	does	do	VBZ
cord-017954-vobslprh	170	47	not	not	RB
cord-017954-vobslprh	170	48	induce	induce	VB
cord-017954-vobslprh	170	49	disease	disease	NN
cord-017954-vobslprh	170	50	in	in	IN
cord-017954-vobslprh	170	51	rats	rat	NNS
cord-017954-vobslprh	170	52	.	.	.
cord-017954-vobslprh	171	1	Furthermore	furthermore	RB
cord-017954-vobslprh	171	2	,	,	,
cord-017954-vobslprh	171	3	immunization	immunization	NN
cord-017954-vobslprh	171	4	of	of	IN
cord-017954-vobslprh	171	5	rats	rat	NNS
cord-017954-vobslprh	171	6	with	with	IN
cord-017954-vobslprh	171	7	various	various	JJ
cord-017954-vobslprh	171	8	gangliosides	ganglioside	NNS
cord-017954-vobslprh	171	9	,	,	,
cord-017954-vobslprh	171	10	the	the	DT
cord-017954-vobslprh	171	11	main	main	JJ
cord-017954-vobslprh	171	12	immunological	immunological	JJ
cord-017954-vobslprh	171	13	target	target	NN
cord-017954-vobslprh	171	14	of	of	IN
cord-017954-vobslprh	171	15	the	the	DT
cord-017954-vobslprh	171	16	immune	immune	JJ
cord-017954-vobslprh	171	17	system	system	NN
cord-017954-vobslprh	171	18	in	in	IN
cord-017954-vobslprh	171	19	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	171	20	jejuni	jejuni	NNP
cord-017954-vobslprh	171	21	-	-	HYPH
cord-017954-vobslprh	171	22	induced	induce	VBN
cord-017954-vobslprh	171	23	GBS	GBS	NNP
cord-017954-vobslprh	171	24	,	,	,
cord-017954-vobslprh	171	25	also	also	RB
cord-017954-vobslprh	171	26	does	do	VBZ
cord-017954-vobslprh	171	27	not	not	RB
cord-017954-vobslprh	171	28	induce	induce	VB
cord-017954-vobslprh	171	29	disease	disease	NN
cord-017954-vobslprh	171	30	[	[	-LRB-
cord-017954-vobslprh	171	31	72	72	CD
cord-017954-vobslprh	171	32	]	]	-RRB-
cord-017954-vobslprh	171	33	.	.	.
cord-017954-vobslprh	172	1	The	the	DT
cord-017954-vobslprh	172	2	addition	addition	NN
cord-017954-vobslprh	172	3	of	of	IN
cord-017954-vobslprh	172	4	gangliosides	ganglioside	NNS
cord-017954-vobslprh	172	5	to	to	IN
cord-017954-vobslprh	172	6	immunization	immunization	NN
cord-017954-vobslprh	172	7	protocols	protocol	NNS
cord-017954-vobslprh	172	8	failed	fail	VBD
cord-017954-vobslprh	172	9	to	to	TO
cord-017954-vobslprh	172	10	have	have	VB
cord-017954-vobslprh	172	11	an	an	DT
cord-017954-vobslprh	172	12	enhancing	enhance	VBG
cord-017954-vobslprh	172	13	effect	effect	NN
cord-017954-vobslprh	172	14	of	of	IN
cord-017954-vobslprh	172	15	EAN	EAN	NNP
cord-017954-vobslprh	172	16	severity	severity	NN
cord-017954-vobslprh	172	17	or	or	CC
cord-017954-vobslprh	172	18	disease	disease	NN
cord-017954-vobslprh	172	19	onset	onset	NN
cord-017954-vobslprh	172	20	.	.	.
cord-017954-vobslprh	173	1	Although	although	IN
cord-017954-vobslprh	173	2	other	other	JJ
cord-017954-vobslprh	173	3	species	specie	NNS
cord-017954-vobslprh	173	4	of	of	IN
cord-017954-vobslprh	173	5	animals	animal	NNS
cord-017954-vobslprh	173	6	have	have	VBP
cord-017954-vobslprh	173	7	shown	show	VBN
cord-017954-vobslprh	173	8	some	some	DT
cord-017954-vobslprh	173	9	promise	promise	NN
cord-017954-vobslprh	173	10	in	in	IN
cord-017954-vobslprh	173	11	terms	term	NNS
cord-017954-vobslprh	173	12	of	of	IN
cord-017954-vobslprh	173	13	developing	develop	VBG
cord-017954-vobslprh	173	14	conduction	conduction	NN
cord-017954-vobslprh	173	15	block	block	NN
cord-017954-vobslprh	173	16	(	(	-LRB-
cord-017954-vobslprh	173	17	rabbits	rabbit	NNS
cord-017954-vobslprh	173	18	immunized	immunize	VBN
cord-017954-vobslprh	173	19	with	with	IN
cord-017954-vobslprh	173	20	GM1	GM1	NNP
cord-017954-vobslprh	173	21	demonstrated	demonstrate	VBD
cord-017954-vobslprh	173	22	sciatic	sciatic	JJ
cord-017954-vobslprh	173	23	nerve	nerve	NN
cord-017954-vobslprh	173	24	conduction	conduction	NN
cord-017954-vobslprh	173	25	block	block	NN
cord-017954-vobslprh	173	26	[	[	-LRB-
cord-017954-vobslprh	173	27	73	73	CD
cord-017954-vobslprh	173	28	]	]	-RRB-
cord-017954-vobslprh	174	1	,	,	,
cord-017954-vobslprh	174	2	33/100	33/100	CD
cord-017954-vobslprh	174	3	chickens	chicken	NNS
cord-017954-vobslprh	174	4	administered	administer	VBD
cord-017954-vobslprh	174	5	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	174	6	jejuni	jejuni	NNP
cord-017954-vobslprh	174	7	isolated	isolate	VBN
cord-017954-vobslprh	174	8	from	from	IN
cord-017954-vobslprh	174	9	a	a	DT
cord-017954-vobslprh	174	10	Chinese	chinese	JJ
cord-017954-vobslprh	174	11	patient	patient	NN
cord-017954-vobslprh	175	1	showed	show	VBD
cord-017954-vobslprh	175	2	sciatic	sciatic	JJ
cord-017954-vobslprh	175	3	nerve	nerve	NN
cord-017954-vobslprh	175	4	Wallerian	wallerian	JJ
cord-017954-vobslprh	175	5	degeneration	degeneration	NN
cord-017954-vobslprh	175	6	with	with	IN
cord-017954-vobslprh	175	7	minor	minor	JJ
cord-017954-vobslprh	175	8	demyelination	demyelination	NN
cord-017954-vobslprh	175	9	)	)	-RRB-
cord-017954-vobslprh	175	10	[	[	-LRB-
cord-017954-vobslprh	175	11	74	74	CD
cord-017954-vobslprh	175	12	]	]	-RRB-
cord-017954-vobslprh	175	13	,	,	,
cord-017954-vobslprh	175	14	these	these	DT
cord-017954-vobslprh	175	15	models	model	NNS
cord-017954-vobslprh	175	16	have	have	VBP
cord-017954-vobslprh	175	17	not	not	RB
cord-017954-vobslprh	175	18	been	be	VBN
cord-017954-vobslprh	175	19	studied	study	VBN
cord-017954-vobslprh	175	20	extensively	extensively	RB
cord-017954-vobslprh	175	21	.	.	.
cord-017954-vobslprh	176	1	Therefore	therefore	RB
cord-017954-vobslprh	176	2	,	,	,
cord-017954-vobslprh	176	3	the	the	DT
cord-017954-vobslprh	176	4	existing	exist	VBG
cord-017954-vobslprh	176	5	EAN	EAN	NNP
cord-017954-vobslprh	176	6	model	model	NN
cord-017954-vobslprh	176	7	is	be	VBZ
cord-017954-vobslprh	176	8	useful	useful	JJ
cord-017954-vobslprh	176	9	for	for	IN
cord-017954-vobslprh	176	10	studies	study	NNS
cord-017954-vobslprh	176	11	related	relate	VBN
cord-017954-vobslprh	176	12	to	to	IN
cord-017954-vobslprh	176	13	the	the	DT
cord-017954-vobslprh	176	14	effector	effector	NN
cord-017954-vobslprh	176	15	phase	phase	NN
cord-017954-vobslprh	176	16	immune	immune	NN
cord-017954-vobslprh	176	17	-	-	HYPH
cord-017954-vobslprh	176	18	mediated	mediate	VBN
cord-017954-vobslprh	176	19	mechanisms	mechanism	NNS
cord-017954-vobslprh	176	20	of	of	IN
cord-017954-vobslprh	176	21	peripheral	peripheral	JJ
cord-017954-vobslprh	176	22	nerve	nerve	NN
cord-017954-vobslprh	176	23	demyelination	demyelination	NN
cord-017954-vobslprh	176	24	;	;	:
cord-017954-vobslprh	176	25	it	-PRON-	PRP
cord-017954-vobslprh	176	26	is	be	VBZ
cord-017954-vobslprh	176	27	less	less	RBR
cord-017954-vobslprh	176	28	useful	useful	JJ
cord-017954-vobslprh	176	29	for	for	IN
cord-017954-vobslprh	176	30	studies	study	NNS
cord-017954-vobslprh	176	31	to	to	TO
cord-017954-vobslprh	176	32	determine	determine	VB
cord-017954-vobslprh	176	33	the	the	DT
cord-017954-vobslprh	176	34	pathogenic	pathogenic	JJ
cord-017954-vobslprh	176	35	mechanisms	mechanism	NNS
cord-017954-vobslprh	176	36	involved	involve	VBN
cord-017954-vobslprh	176	37	following	follow	VBG
cord-017954-vobslprh	176	38	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	176	39	jejuni	jejuni	NNP
cord-017954-vobslprh	176	40	infection	infection	NN
cord-017954-vobslprh	176	41	.	.	.
cord-017954-vobslprh	177	1	Myasthenia	myasthenia	NN
cord-017954-vobslprh	177	2	gravis	gravis	NN
cord-017954-vobslprh	177	3	(	(	-LRB-
cord-017954-vobslprh	177	4	MG	MG	NNP
cord-017954-vobslprh	177	5	)	)	-RRB-
cord-017954-vobslprh	177	6	is	be	VBZ
cord-017954-vobslprh	177	7	a	a	DT
cord-017954-vobslprh	177	8	rare	rare	JJ
cord-017954-vobslprh	177	9	neuromuscular	neuromuscular	JJ
cord-017954-vobslprh	177	10	disease	disease	NN
cord-017954-vobslprh	177	11	that	that	WDT
cord-017954-vobslprh	177	12	causes	cause	VBZ
cord-017954-vobslprh	177	13	excessive	excessive	JJ
cord-017954-vobslprh	177	14	fatigue	fatigue	NN
cord-017954-vobslprh	177	15	and	and	CC
cord-017954-vobslprh	177	16	generalized	generalized	JJ
cord-017954-vobslprh	177	17	muscle	muscle	NN
cord-017954-vobslprh	177	18	weakness	weakness	NN
cord-017954-vobslprh	177	19	that	that	WDT
cord-017954-vobslprh	177	20	can	can	MD
cord-017954-vobslprh	177	21	fluctuate	fluctuate	VB
cord-017954-vobslprh	177	22	and	and	CC
cord-017954-vobslprh	177	23	is	be	VBZ
cord-017954-vobslprh	177	24	characterized	characterize	VBN
cord-017954-vobslprh	177	25	by	by	IN
cord-017954-vobslprh	177	26	clinical	clinical	JJ
cord-017954-vobslprh	177	27	symptoms	symptom	NNS
cord-017954-vobslprh	177	28	including	include	VBG
cord-017954-vobslprh	177	29	ptosis	ptosis	NN
cord-017954-vobslprh	177	30	and	and	CC
cord-017954-vobslprh	177	31	diplopia	diplopia	NN
cord-017954-vobslprh	177	32	.	.	.
cord-017954-vobslprh	178	1	Muscle	muscle	NN
cord-017954-vobslprh	178	2	weakness	weakness	NN
cord-017954-vobslprh	178	3	often	often	RB
cord-017954-vobslprh	178	4	worsens	worsen	VBZ
cord-017954-vobslprh	178	5	upon	upon	IN
cord-017954-vobslprh	178	6	use	use	NN
cord-017954-vobslprh	178	7	but	but	CC
cord-017954-vobslprh	178	8	usually	usually	RB
cord-017954-vobslprh	178	9	improves	improve	VBZ
cord-017954-vobslprh	178	10	with	with	IN
cord-017954-vobslprh	178	11	rest	rest	NN
cord-017954-vobslprh	178	12	.	.	.
cord-017954-vobslprh	179	1	As	as	IN
cord-017954-vobslprh	179	2	the	the	DT
cord-017954-vobslprh	179	3	disease	disease	NN
cord-017954-vobslprh	179	4	course	course	NN
cord-017954-vobslprh	179	5	of	of	IN
cord-017954-vobslprh	179	6	MG	MG	NNP
cord-017954-vobslprh	179	7	progresses	progress	VBZ
cord-017954-vobslprh	179	8	,	,	,
cord-017954-vobslprh	179	9	bulbar	bulbar	NN
cord-017954-vobslprh	179	10	and	and	CC
cord-017954-vobslprh	179	11	respiratory	respiratory	JJ
cord-017954-vobslprh	179	12	muscle	muscle	NN
cord-017954-vobslprh	179	13	weakness	weakness	NN
cord-017954-vobslprh	179	14	worsens	worsen	VBZ
cord-017954-vobslprh	179	15	,	,	,
cord-017954-vobslprh	179	16	which	which	WDT
cord-017954-vobslprh	179	17	can	can	MD
cord-017954-vobslprh	179	18	become	become	VB
cord-017954-vobslprh	179	19	life	life	NN
cord-017954-vobslprh	179	20	-	-	HYPH
cord-017954-vobslprh	179	21	threatening	threaten	VBG
cord-017954-vobslprh	179	22	,	,	,
cord-017954-vobslprh	179	23	often	often	RB
cord-017954-vobslprh	179	24	requiring	require	VBG
cord-017954-vobslprh	179	25	the	the	DT
cord-017954-vobslprh	179	26	use	use	NN
cord-017954-vobslprh	179	27	of	of	IN
cord-017954-vobslprh	179	28	mechanical	mechanical	JJ
cord-017954-vobslprh	179	29	ventilation	ventilation	NN
cord-017954-vobslprh	179	30	by	by	IN
cord-017954-vobslprh	179	31	intubation	intubation	NN
cord-017954-vobslprh	179	32	.	.	.
cord-017954-vobslprh	180	1	MG	MG	NNP
cord-017954-vobslprh	180	2	is	be	VBZ
cord-017954-vobslprh	180	3	thought	think	VBN
cord-017954-vobslprh	180	4	to	to	TO
cord-017954-vobslprh	180	5	be	be	VB
cord-017954-vobslprh	180	6	a	a	DT
cord-017954-vobslprh	180	7	T	T	NNP
cord-017954-vobslprh	180	8	cell	cell	NN
cord-017954-vobslprh	180	9	-	-	HYPH
cord-017954-vobslprh	180	10	dependent	dependent	JJ
cord-017954-vobslprh	180	11	antibody	antibody	NN
cord-017954-vobslprh	180	12	-	-	HYPH
cord-017954-vobslprh	180	13	mediated	mediate	VBN
cord-017954-vobslprh	180	14	autoimmune	autoimmune	JJ
cord-017954-vobslprh	180	15	disease	disease	NN
cord-017954-vobslprh	180	16	because	because	IN
cord-017954-vobslprh	180	17	approximately	approximately	RB
cord-017954-vobslprh	180	18	80	80	CD
cord-017954-vobslprh	180	19	%	%	NN
cord-017954-vobslprh	180	20	of	of	IN
cord-017954-vobslprh	180	21	MG	MG	NNP
cord-017954-vobslprh	180	22	patients	patient	NNS
cord-017954-vobslprh	180	23	have	have	VBP
cord-017954-vobslprh	180	24	autoantibodies	autoantibody	NNS
cord-017954-vobslprh	180	25	against	against	IN
cord-017954-vobslprh	180	26	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	180	27	receptors	receptor	NNS
cord-017954-vobslprh	180	28	(	(	-LRB-
cord-017954-vobslprh	180	29	AChR	achr	VB
cord-017954-vobslprh	180	30	)	)	-RRB-
cord-017954-vobslprh	180	31	[	[	-LRB-
cord-017954-vobslprh	180	32	75	75	CD
cord-017954-vobslprh	180	33	,	,	,
cord-017954-vobslprh	180	34	76	76	CD
cord-017954-vobslprh	180	35	]	]	-RRB-
cord-017954-vobslprh	180	36	,	,	,
cord-017954-vobslprh	180	37	possibly	possibly	RB
cord-017954-vobslprh	180	38	as	as	IN
cord-017954-vobslprh	180	39	a	a	DT
cord-017954-vobslprh	180	40	consequence	consequence	NN
cord-017954-vobslprh	180	41	of	of	IN
cord-017954-vobslprh	180	42	the	the	DT
cord-017954-vobslprh	180	43	loss	loss	NN
cord-017954-vobslprh	180	44	of	of	IN
cord-017954-vobslprh	180	45	"	"	''
cord-017954-vobslprh	180	46	self"tolerance	self"tolerance	''
cord-017954-vobslprh	180	47	in	in	IN
cord-017954-vobslprh	180	48	the	the	DT
cord-017954-vobslprh	180	49	thymus	thymus	NN
cord-017954-vobslprh	180	50	[	[	-LRB-
cord-017954-vobslprh	180	51	77	77	CD
cord-017954-vobslprh	180	52	]	]	-RRB-
cord-017954-vobslprh	180	53	.	.	.
cord-017954-vobslprh	181	1	AChR	achr	JJ
cord-017954-vobslprh	181	2	antibodies	antibody	NNS
cord-017954-vobslprh	181	3	bind	bind	VBP
cord-017954-vobslprh	181	4	to	to	IN
cord-017954-vobslprh	181	5	AChR	AChR	NNP
cord-017954-vobslprh	181	6	expressed	express	VBN
cord-017954-vobslprh	181	7	at	at	IN
cord-017954-vobslprh	181	8	neuromuscular	neuromuscular	JJ
cord-017954-vobslprh	181	9	junctions	junction	NNS
cord-017954-vobslprh	181	10	(	(	-LRB-
cord-017954-vobslprh	181	11	NMJ	NMJ	NNP
cord-017954-vobslprh	181	12	)	)	-RRB-
cord-017954-vobslprh	181	13	and	and	CC
cord-017954-vobslprh	181	14	block	block	VB
cord-017954-vobslprh	181	15	neuromuscular	neuromuscular	JJ
cord-017954-vobslprh	181	16	transmission	transmission	NN
cord-017954-vobslprh	181	17	.	.	.
cord-017954-vobslprh	182	1	Interestingly	interestingly	RB
cord-017954-vobslprh	182	2	,	,	,
cord-017954-vobslprh	182	3	the	the	DT
cord-017954-vobslprh	182	4	first	first	JJ
cord-017954-vobslprh	182	5	experimental	experimental	JJ
cord-017954-vobslprh	182	6	evidence	evidence	NN
cord-017954-vobslprh	182	7	to	to	TO
cord-017954-vobslprh	182	8	suggest	suggest	VB
cord-017954-vobslprh	182	9	AChR	achr	JJ
cord-017954-vobslprh	182	10	antibodies	antibody	NNS
cord-017954-vobslprh	182	11	might	may	MD
cord-017954-vobslprh	182	12	be	be	VB
cord-017954-vobslprh	182	13	pathogenic	pathogenic	JJ
cord-017954-vobslprh	182	14	was	be	VBD
cord-017954-vobslprh	182	15	demonstrated	demonstrate	VBN
cord-017954-vobslprh	182	16	using	use	VBG
cord-017954-vobslprh	182	17	an	an	DT
cord-017954-vobslprh	182	18	experimental	experimental	JJ
cord-017954-vobslprh	182	19	rabbit	rabbit	NN
cord-017954-vobslprh	182	20	model	model	NN
cord-017954-vobslprh	182	21	where	where	WRB
cord-017954-vobslprh	182	22	immunization	immunization	NN
cord-017954-vobslprh	182	23	with	with	IN
cord-017954-vobslprh	182	24	purified	purify	VBN
cord-017954-vobslprh	182	25	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	182	26	receptor	receptor	NN
cord-017954-vobslprh	182	27	in	in	IN
cord-017954-vobslprh	182	28	complete	complete	JJ
cord-017954-vobslprh	182	29	Freund	Freund	NNP
cord-017954-vobslprh	182	30	's	's	POS
cord-017954-vobslprh	182	31	adjuvant	adjuvant	NN
cord-017954-vobslprh	182	32	induced	induce	VBD
cord-017954-vobslprh	182	33	the	the	DT
cord-017954-vobslprh	182	34	production	production	NN
cord-017954-vobslprh	182	35	of	of	IN
cord-017954-vobslprh	182	36	antibodies	antibody	NNS
cord-017954-vobslprh	182	37	to	to	IN
cord-017954-vobslprh	182	38	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	182	39	receptor	receptor	NN
cord-017954-vobslprh	182	40	,	,	,
cord-017954-vobslprh	182	41	which	which	WDT
cord-017954-vobslprh	182	42	mediated	mediate	VBD
cord-017954-vobslprh	182	43	neuromuscular	neuromuscular	NN
cord-017954-vobslprh	182	44	blockade	blockade	NN
cord-017954-vobslprh	182	45	that	that	WDT
cord-017954-vobslprh	182	46	caused	cause	VBD
cord-017954-vobslprh	182	47	flaccid	flaccid	JJ
cord-017954-vobslprh	182	48	paralysis	paralysis	NN
cord-017954-vobslprh	182	49	and	and	CC
cord-017954-vobslprh	182	50	MG	MG	NNP
cord-017954-vobslprh	182	51	-	-	HYPH
cord-017954-vobslprh	182	52	like	like	JJ
cord-017954-vobslprh	182	53	symptoms	symptom	NNS
cord-017954-vobslprh	182	54	[	[	-LRB-
cord-017954-vobslprh	182	55	78	78	CD
cord-017954-vobslprh	182	56	]	]	-RRB-
cord-017954-vobslprh	182	57	.	.	.
cord-017954-vobslprh	183	1	Despite	despite	IN
cord-017954-vobslprh	183	2	the	the	DT
cord-017954-vobslprh	183	3	early	early	JJ
cord-017954-vobslprh	183	4	identification	identification	NN
cord-017954-vobslprh	183	5	of	of	IN
cord-017954-vobslprh	183	6	AChR	achr	JJ
cord-017954-vobslprh	183	7	antibodies	antibody	NNS
cord-017954-vobslprh	183	8	as	as	IN
cord-017954-vobslprh	183	9	potential	potential	JJ
cord-017954-vobslprh	183	10	mediators	mediator	NNS
cord-017954-vobslprh	183	11	of	of	IN
cord-017954-vobslprh	183	12	disease	disease	NN
cord-017954-vobslprh	183	13	,	,	,
cord-017954-vobslprh	183	14	the	the	DT
cord-017954-vobslprh	183	15	mechanisms	mechanism	NNS
cord-017954-vobslprh	183	16	involved	involve	VBN
cord-017954-vobslprh	183	17	that	that	WDT
cord-017954-vobslprh	183	18	precede	precede	VBP
cord-017954-vobslprh	183	19	the	the	DT
cord-017954-vobslprh	183	20	production	production	NN
cord-017954-vobslprh	183	21	of	of	IN
cord-017954-vobslprh	183	22	AChR	achr	JJ
cord-017954-vobslprh	183	23	antibodies	antibody	NNS
cord-017954-vobslprh	183	24	are	be	VBP
cord-017954-vobslprh	183	25	less	less	RBR
cord-017954-vobslprh	183	26	clear	clear	JJ
cord-017954-vobslprh	183	27	,	,	,
cord-017954-vobslprh	183	28	although	although	IN
cord-017954-vobslprh	183	29	involvement	involvement	NN
cord-017954-vobslprh	183	30	of	of	IN
cord-017954-vobslprh	183	31	the	the	DT
cord-017954-vobslprh	183	32	thymus	thymus	NN
cord-017954-vobslprh	183	33	has	have	VBZ
cord-017954-vobslprh	183	34	been	be	VBN
cord-017954-vobslprh	183	35	indicated	indicate	VBN
cord-017954-vobslprh	183	36	.	.	.
cord-017954-vobslprh	184	1	The	the	DT
cord-017954-vobslprh	184	2	symptomatic	symptomatic	JJ
cord-017954-vobslprh	184	3	treatment	treatment	NN
cord-017954-vobslprh	184	4	of	of	IN
cord-017954-vobslprh	184	5	MG	MG	NNP
cord-017954-vobslprh	184	6	using	use	VBG
cord-017954-vobslprh	184	7	acetylcholinesterase	acetylcholinesterase	NN
cord-017954-vobslprh	184	8	inhibitors	inhibitor	NNS
cord-017954-vobslprh	184	9	and/or	and/or	CC
cord-017954-vobslprh	184	10	immunosuppressive	immunosuppressive	JJ
cord-017954-vobslprh	184	11	drugs	drug	NNS
cord-017954-vobslprh	184	12	can	can	MD
cord-017954-vobslprh	184	13	improve	improve	VB
cord-017954-vobslprh	184	14	muscle	muscle	NN
cord-017954-vobslprh	184	15	function	function	NN
cord-017954-vobslprh	184	16	although	although	IN
cord-017954-vobslprh	184	17	these	these	DT
cord-017954-vobslprh	184	18	treatments	treatment	NNS
cord-017954-vobslprh	184	19	are	be	VBP
cord-017954-vobslprh	184	20	limited	limit	VBN
cord-017954-vobslprh	184	21	by	by	IN
cord-017954-vobslprh	184	22	either	either	CC
cord-017954-vobslprh	184	23	a	a	DT
cord-017954-vobslprh	184	24	reduction	reduction	NN
cord-017954-vobslprh	184	25	in	in	IN
cord-017954-vobslprh	184	26	efficacy	efficacy	NN
cord-017954-vobslprh	184	27	over	over	IN
cord-017954-vobslprh	184	28	time	time	NN
cord-017954-vobslprh	184	29	or	or	CC
cord-017954-vobslprh	184	30	severe	severe	JJ
cord-017954-vobslprh	184	31	side	side	NN
cord-017954-vobslprh	184	32	effects	effect	NNS
cord-017954-vobslprh	184	33	.	.	.
cord-017954-vobslprh	185	1	Furthermore	furthermore	RB
cord-017954-vobslprh	185	2	,	,	,
cord-017954-vobslprh	185	3	plasma	plasma	NN
cord-017954-vobslprh	185	4	exchange	exchange	NN
cord-017954-vobslprh	185	5	and	and	CC
cord-017954-vobslprh	185	6	surgery	surgery	NN
cord-017954-vobslprh	185	7	in	in	IN
cord-017954-vobslprh	185	8	patients	patient	NNS
cord-017954-vobslprh	185	9	that	that	WDT
cord-017954-vobslprh	185	10	develop	develop	VBP
cord-017954-vobslprh	185	11	thymoma	thymoma	NNS
cord-017954-vobslprh	185	12	are	be	VBP
cord-017954-vobslprh	185	13	invasive	invasive	JJ
cord-017954-vobslprh	185	14	procedures	procedure	NNS
cord-017954-vobslprh	185	15	.	.	.
cord-017954-vobslprh	186	1	Currently	currently	RB
cord-017954-vobslprh	186	2	,	,	,
cord-017954-vobslprh	186	3	no	no	DT
cord-017954-vobslprh	186	4	treatments	treatment	NNS
cord-017954-vobslprh	186	5	directly	directly	RB
cord-017954-vobslprh	186	6	target	target	VB
cord-017954-vobslprh	186	7	the	the	DT
cord-017954-vobslprh	186	8	autoimmune	autoimmune	JJ
cord-017954-vobslprh	186	9	component	component	NN
cord-017954-vobslprh	186	10	of	of	IN
cord-017954-vobslprh	186	11	disease	disease	NN
cord-017954-vobslprh	186	12	,	,	,
cord-017954-vobslprh	186	13	and	and	CC
cord-017954-vobslprh	186	14	therefore	therefore	RB
cord-017954-vobslprh	186	15	,	,	,
cord-017954-vobslprh	186	16	there	there	EX
cord-017954-vobslprh	186	17	is	be	VBZ
cord-017954-vobslprh	186	18	a	a	DT
cord-017954-vobslprh	186	19	still	still	RB
cord-017954-vobslprh	186	20	a	a	DT
cord-017954-vobslprh	186	21	need	need	NN
cord-017954-vobslprh	186	22	for	for	IN
cord-017954-vobslprh	186	23	the	the	DT
cord-017954-vobslprh	186	24	further	further	JJ
cord-017954-vobslprh	186	25	elucidation	elucidation	NN
cord-017954-vobslprh	186	26	of	of	IN
cord-017954-vobslprh	186	27	MG	MG	NNP
cord-017954-vobslprh	186	28	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	186	29	and	and	CC
cord-017954-vobslprh	186	30	the	the	DT
cord-017954-vobslprh	186	31	development	development	NN
cord-017954-vobslprh	186	32	of	of	IN
cord-017954-vobslprh	186	33	novel	novel	JJ
cord-017954-vobslprh	186	34	drugs	drug	NNS
cord-017954-vobslprh	186	35	,	,	,
cord-017954-vobslprh	186	36	which	which	WDT
cord-017954-vobslprh	186	37	highlights	highlight	VBZ
cord-017954-vobslprh	186	38	the	the	DT
cord-017954-vobslprh	186	39	importance	importance	NN
cord-017954-vobslprh	186	40	of	of	IN
cord-017954-vobslprh	186	41	using	use	VBG
cord-017954-vobslprh	186	42	animal	animal	NN
cord-017954-vobslprh	186	43	models	model	NNS
cord-017954-vobslprh	186	44	of	of	IN
cord-017954-vobslprh	186	45	MG	MG	NNP
cord-017954-vobslprh	186	46	.	.	.
cord-017954-vobslprh	187	1	Experimental	experimental	JJ
cord-017954-vobslprh	187	2	autoimmune	autoimmune	JJ
cord-017954-vobslprh	187	3	myasthenia	myasthenia	NN
cord-017954-vobslprh	187	4	gravis	gravis	NN
cord-017954-vobslprh	187	5	(	(	-LRB-
cord-017954-vobslprh	187	6	EAMG	EAMG	NNP
cord-017954-vobslprh	187	7	)	)	-RRB-
cord-017954-vobslprh	187	8	was	be	VBD
cord-017954-vobslprh	187	9	originally	originally	RB
cord-017954-vobslprh	187	10	induced	induce	VBN
cord-017954-vobslprh	187	11	in	in	IN
cord-017954-vobslprh	187	12	rabbits	rabbit	NNS
cord-017954-vobslprh	187	13	by	by	IN
cord-017954-vobslprh	187	14	immunization	immunization	NN
cord-017954-vobslprh	187	15	of	of	IN
cord-017954-vobslprh	187	16	highly	highly	RB
cord-017954-vobslprh	187	17	purified	purify	VBN
cord-017954-vobslprh	187	18	AChR	AChR	NNP
cord-017954-vobslprh	187	19	isolated	isolate	VBN
cord-017954-vobslprh	187	20	from	from	IN
cord-017954-vobslprh	187	21	the	the	DT
cord-017954-vobslprh	187	22	electric	electric	JJ
cord-017954-vobslprh	187	23	organ	organ	NN
cord-017954-vobslprh	187	24	of	of	IN
cord-017954-vobslprh	187	25	Electrophorus	Electrophorus	NNP
cord-017954-vobslprh	187	26	electricus	electricus	NN
cord-017954-vobslprh	187	27	emulsified	emulsify	VBN
cord-017954-vobslprh	187	28	in	in	IN
cord-017954-vobslprh	187	29	complete	complete	JJ
cord-017954-vobslprh	187	30	Freund	Freund	NNP
cord-017954-vobslprh	187	31	's	's	POS
cord-017954-vobslprh	187	32	adjuvant	adjuvant	NN
cord-017954-vobslprh	187	33	[	[	-LRB-
cord-017954-vobslprh	187	34	78	78	CD
cord-017954-vobslprh	187	35	]	]	-RRB-
cord-017954-vobslprh	187	36	.	.	.
cord-017954-vobslprh	188	1	This	this	DT
cord-017954-vobslprh	188	2	induced	induce	VBD
cord-017954-vobslprh	188	3	the	the	DT
cord-017954-vobslprh	188	4	production	production	NN
cord-017954-vobslprh	188	5	of	of	IN
cord-017954-vobslprh	188	6	antibodies	antibody	NNS
cord-017954-vobslprh	188	7	that	that	WDT
cord-017954-vobslprh	188	8	specifically	specifically	RB
cord-017954-vobslprh	188	9	recognize	recognize	VBP
cord-017954-vobslprh	188	10	AChR	AChR	NNP
cord-017954-vobslprh	188	11	and	and	CC
cord-017954-vobslprh	188	12	bind	bind	VB
cord-017954-vobslprh	188	13	to	to	IN
cord-017954-vobslprh	188	14	these	these	DT
cord-017954-vobslprh	188	15	receptors	receptor	NNS
cord-017954-vobslprh	188	16	at	at	IN
cord-017954-vobslprh	188	17	NMJs	nmj	NNS
cord-017954-vobslprh	188	18	,	,	,
cord-017954-vobslprh	188	19	subsequently	subsequently	RB
cord-017954-vobslprh	188	20	blocking	block	VBG
cord-017954-vobslprh	188	21	neurotransmission	neurotransmission	NN
cord-017954-vobslprh	188	22	,	,	,
cord-017954-vobslprh	188	23	causing	cause	VBG
cord-017954-vobslprh	188	24	muscle	muscle	NN
cord-017954-vobslprh	188	25	fatigue	fatigue	NN
cord-017954-vobslprh	188	26	and	and	CC
cord-017954-vobslprh	188	27	weakness	weakness	NN
cord-017954-vobslprh	188	28	,	,	,
cord-017954-vobslprh	188	29	which	which	WDT
cord-017954-vobslprh	188	30	mimic	mimic	VBP
cord-017954-vobslprh	188	31	the	the	DT
cord-017954-vobslprh	188	32	symptoms	symptom	NNS
cord-017954-vobslprh	188	33	observed	observe	VBN
cord-017954-vobslprh	188	34	in	in	IN
cord-017954-vobslprh	188	35	human	human	JJ
cord-017954-vobslprh	188	36	MG	MG	NNP
cord-017954-vobslprh	188	37	.	.	.
cord-017954-vobslprh	189	1	Since	since	IN
cord-017954-vobslprh	189	2	the	the	DT
cord-017954-vobslprh	189	3	first	first	JJ
cord-017954-vobslprh	189	4	description	description	NN
cord-017954-vobslprh	189	5	of	of	IN
cord-017954-vobslprh	189	6	EAMG	EAMG	NNP
cord-017954-vobslprh	189	7	,	,	,
cord-017954-vobslprh	189	8	it	-PRON-	PRP
cord-017954-vobslprh	189	9	has	have	VBZ
cord-017954-vobslprh	189	10	been	be	VBN
cord-017954-vobslprh	189	11	induced	induce	VBN
cord-017954-vobslprh	189	12	in	in	IN
cord-017954-vobslprh	189	13	a	a	DT
cord-017954-vobslprh	189	14	wide	wide	JJ
cord-017954-vobslprh	189	15	variety	variety	NN
cord-017954-vobslprh	189	16	of	of	IN
cord-017954-vobslprh	189	17	animals	animal	NNS
cord-017954-vobslprh	189	18	including	include	VBG
cord-017954-vobslprh	189	19	rabbits	rabbit	NNS
cord-017954-vobslprh	189	20	[	[	-LRB-
cord-017954-vobslprh	189	21	78	78	CD
cord-017954-vobslprh	189	22	,	,	,
cord-017954-vobslprh	189	23	79	79	CD
cord-017954-vobslprh	189	24	]	]	-RRB-
cord-017954-vobslprh	189	25	rats	rat	NNS
cord-017954-vobslprh	189	26	[	[	-LRB-
cord-017954-vobslprh	189	27	80	80	CD
cord-017954-vobslprh	189	28	]	]	-RRB-
cord-017954-vobslprh	189	29	,	,	,
cord-017954-vobslprh	189	30	mice	mouse	NNS
cord-017954-vobslprh	189	31	[	[	-LRB-
cord-017954-vobslprh	189	32	81	81	CD
cord-017954-vobslprh	189	33	,	,	,
cord-017954-vobslprh	189	34	82	82	CD
cord-017954-vobslprh	189	35	]	]	-RRB-
cord-017954-vobslprh	189	36	,	,	,
cord-017954-vobslprh	189	37	guinea	guinea	NN
cord-017954-vobslprh	189	38	pigs	pig	NNS
cord-017954-vobslprh	189	39	[	[	-LRB-
cord-017954-vobslprh	189	40	80	80	CD
cord-017954-vobslprh	189	41	]	]	-RRB-
cord-017954-vobslprh	189	42	,	,	,
cord-017954-vobslprh	189	43	goats	goat	NNS
cord-017954-vobslprh	189	44	[	[	-LRB-
cord-017954-vobslprh	189	45	83	83	CD
cord-017954-vobslprh	189	46	]	]	-RRB-
cord-017954-vobslprh	189	47	,	,	,
cord-017954-vobslprh	189	48	monkeys	monkey	NNS
cord-017954-vobslprh	189	49	[	[	-LRB-
cord-017954-vobslprh	189	50	84	84	CD
cord-017954-vobslprh	189	51	]	]	-RRB-
cord-017954-vobslprh	189	52	,	,	,
cord-017954-vobslprh	189	53	and	and	CC
cord-017954-vobslprh	189	54	frogs	frog	NNS
cord-017954-vobslprh	189	55	[	[	-LRB-
cord-017954-vobslprh	189	56	85	85	CD
cord-017954-vobslprh	189	57	]	]	-RRB-
cord-017954-vobslprh	189	58	.	.	.
cord-017954-vobslprh	190	1	Currently	currently	RB
cord-017954-vobslprh	190	2	,	,	,
cord-017954-vobslprh	190	3	rat	rat	NN
cord-017954-vobslprh	190	4	and	and	CC
cord-017954-vobslprh	190	5	mouse	mouse	NN
cord-017954-vobslprh	190	6	models	model	NNS
cord-017954-vobslprh	190	7	are	be	VBP
cord-017954-vobslprh	190	8	the	the	DT
cord-017954-vobslprh	190	9	animal	animal	NN
cord-017954-vobslprh	190	10	models	model	NNS
cord-017954-vobslprh	190	11	of	of	IN
cord-017954-vobslprh	190	12	choice	choice	NN
cord-017954-vobslprh	190	13	,	,	,
cord-017954-vobslprh	190	14	as	as	IN
cord-017954-vobslprh	190	15	gene	gene	NN
cord-017954-vobslprh	190	16	knockout	knockout	NN
cord-017954-vobslprh	190	17	and	and	CC
cord-017954-vobslprh	190	18	transgenic	transgenic	JJ
cord-017954-vobslprh	190	19	technology	technology	NN
cord-017954-vobslprh	190	20	has	have	VBZ
cord-017954-vobslprh	190	21	allowed	allow	VBN
cord-017954-vobslprh	190	22	a	a	DT
cord-017954-vobslprh	190	23	greater	great	JJR
cord-017954-vobslprh	190	24	in	in	IN
cord-017954-vobslprh	190	25	-	-	HYPH
cord-017954-vobslprh	190	26	depth	depth	NN
cord-017954-vobslprh	190	27	investigation	investigation	NN
cord-017954-vobslprh	190	28	into	into	IN
cord-017954-vobslprh	190	29	the	the	DT
cord-017954-vobslprh	190	30	specific	specific	JJ
cord-017954-vobslprh	190	31	molecules	molecule	NNS
cord-017954-vobslprh	190	32	involved	involve	VBN
cord-017954-vobslprh	190	33	in	in	IN
cord-017954-vobslprh	190	34	disease	disease	NN
cord-017954-vobslprh	190	35	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	190	36	.	.	.
cord-017954-vobslprh	191	1	Susceptible	susceptible	JJ
cord-017954-vobslprh	191	2	rat	rat	NN
cord-017954-vobslprh	191	3	strains	strain	NNS
cord-017954-vobslprh	191	4	include	include	VBP
cord-017954-vobslprh	191	5	Lewis	Lewis	NNP
cord-017954-vobslprh	191	6	,	,	,
cord-017954-vobslprh	191	7	Fischer	Fischer	NNP
cord-017954-vobslprh	191	8	,	,	,
cord-017954-vobslprh	191	9	and	and	CC
cord-017954-vobslprh	191	10	Wistar	Wistar	NNP
cord-017954-vobslprh	191	11	-	-	HYPH
cord-017954-vobslprh	191	12	Munich	Munich	NNP
cord-017954-vobslprh	191	13	rats	rat	NNS
cord-017954-vobslprh	191	14	,	,	,
cord-017954-vobslprh	191	15	and	and	CC
cord-017954-vobslprh	191	16	nonresponder	nonresponder	NNP
cord-017954-vobslprh	191	17	strains	strain	NNS
cord-017954-vobslprh	191	18	include	include	VBP
cord-017954-vobslprh	191	19	Wistar	Wistar	NNP
cord-017954-vobslprh	191	20	Furth	Furth	NNP
cord-017954-vobslprh	191	21	and	and	CC
cord-017954-vobslprh	191	22	Copenhagen	Copenhagen	NNP
cord-017954-vobslprh	191	23	rats	rat	NNS
cord-017954-vobslprh	191	24	.	.	.
cord-017954-vobslprh	192	1	It	-PRON-	PRP
cord-017954-vobslprh	192	2	is	be	VBZ
cord-017954-vobslprh	192	3	important	important	JJ
cord-017954-vobslprh	192	4	to	to	TO
cord-017954-vobslprh	192	5	note	note	VB
cord-017954-vobslprh	192	6	that	that	IN
cord-017954-vobslprh	192	7	some	some	DT
cord-017954-vobslprh	192	8	mouse	mouse	NN
cord-017954-vobslprh	192	9	strains	strain	NNS
cord-017954-vobslprh	192	10	have	have	VBP
cord-017954-vobslprh	192	11	different	different	JJ
cord-017954-vobslprh	192	12	susceptibilities	susceptibility	NNS
cord-017954-vobslprh	192	13	to	to	IN
cord-017954-vobslprh	192	14	EAMG	EAMG	NNP
cord-017954-vobslprh	192	15	;	;	:
cord-017954-vobslprh	192	16	H-2	H-2	NNP
cord-017954-vobslprh	192	17	b	b	NNP
cord-017954-vobslprh	192	18	,	,	,
cord-017954-vobslprh	192	19	s	s	POS
cord-017954-vobslprh	192	20	haplotype	haplotype	NN
cord-017954-vobslprh	192	21	strains	strain	NNS
cord-017954-vobslprh	192	22	(	(	-LRB-
cord-017954-vobslprh	192	23	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	192	24	and	and	CC
cord-017954-vobslprh	192	25	SJL	SJL	NNP
cord-017954-vobslprh	192	26	/	/	SYM
cord-017954-vobslprh	192	27	J	J	NNP
cord-017954-vobslprh	192	28	)	)	-RRB-
cord-017954-vobslprh	192	29	are	be	VBP
cord-017954-vobslprh	192	30	high	high	JJ
cord-017954-vobslprh	192	31	responders	responder	NNS
cord-017954-vobslprh	192	32	,	,	,
cord-017954-vobslprh	192	33	whereas	whereas	IN
cord-017954-vobslprh	192	34	H-2	H-2	NNP
cord-017954-vobslprh	192	35	k	k	NNP
cord-017954-vobslprh	192	36	,	,	,
cord-017954-vobslprh	192	37	p	p	NN
cord-017954-vobslprh	192	38	haplotypes	haplotype	NNS
cord-017954-vobslprh	192	39	are	be	VBP
cord-017954-vobslprh	192	40	nonresponders	nonresponder	NNS
cord-017954-vobslprh	192	41	;	;	:
cord-017954-vobslprh	192	42	therefore	therefore	RB
cord-017954-vobslprh	192	43	,	,	,
cord-017954-vobslprh	192	44	it	-PRON-	PRP
cord-017954-vobslprh	192	45	is	be	VBZ
cord-017954-vobslprh	192	46	important	important	JJ
cord-017954-vobslprh	192	47	to	to	TO
cord-017954-vobslprh	192	48	determine	determine	VB
cord-017954-vobslprh	192	49	the	the	DT
cord-017954-vobslprh	192	50	strain	strain	NN
cord-017954-vobslprh	192	51	used	use	VBN
cord-017954-vobslprh	192	52	before	before	IN
cord-017954-vobslprh	192	53	initiating	initiate	VBG
cord-017954-vobslprh	192	54	studies	study	NNS
cord-017954-vobslprh	192	55	[	[	-LRB-
cord-017954-vobslprh	192	56	81	81	CD
cord-017954-vobslprh	192	57	,	,	,
cord-017954-vobslprh	192	58	86	86	CD
cord-017954-vobslprh	192	59	]	]	-RRB-
cord-017954-vobslprh	192	60	.	.	.
cord-017954-vobslprh	193	1	Interestingly	interestingly	RB
cord-017954-vobslprh	193	2	,	,	,
cord-017954-vobslprh	193	3	rats	rat	NNS
cord-017954-vobslprh	193	4	appear	appear	VBP
cord-017954-vobslprh	193	5	to	to	TO
cord-017954-vobslprh	193	6	be	be	VB
cord-017954-vobslprh	193	7	more	more	RBR
cord-017954-vobslprh	193	8	susceptible	susceptible	JJ
cord-017954-vobslprh	193	9	to	to	IN
cord-017954-vobslprh	193	10	EAMG	EAMG	NNP
cord-017954-vobslprh	193	11	than	than	IN
cord-017954-vobslprh	193	12	mice	mouse	NNS
cord-017954-vobslprh	193	13	,	,	.
cord-017954-vobslprh	194	1	as	as	RB
cord-017954-vobslprh	194	2	usually	usually	RB
cord-017954-vobslprh	194	3	only	only	RB
cord-017954-vobslprh	194	4	one	one	CD
cord-017954-vobslprh	194	5	immunization	immunization	NN
cord-017954-vobslprh	194	6	with	with	IN
cord-017954-vobslprh	194	7	AChR	AChR	NNP
cord-017954-vobslprh	194	8	in	in	IN
cord-017954-vobslprh	194	9	complete	complete	JJ
cord-017954-vobslprh	194	10	Freund	Freund	NNP
cord-017954-vobslprh	194	11	's	's	POS
cord-017954-vobslprh	194	12	adjuvant	adjuvant	NN
cord-017954-vobslprh	194	13	is	be	VBZ
cord-017954-vobslprh	194	14	required	require	VBN
cord-017954-vobslprh	194	15	to	to	TO
cord-017954-vobslprh	194	16	induce	induce	VB
cord-017954-vobslprh	194	17	autoantibodies	autoantibody	NNS
cord-017954-vobslprh	194	18	to	to	IN
cord-017954-vobslprh	194	19	AChR.	achr.	NN
cord-017954-vobslprh	195	1	In	in	IN
cord-017954-vobslprh	195	2	contrast	contrast	NN
cord-017954-vobslprh	195	3	,	,	,
cord-017954-vobslprh	195	4	susceptible	susceptible	JJ
cord-017954-vobslprh	195	5	mouse	mouse	NN
cord-017954-vobslprh	195	6	strains	strain	NNS
cord-017954-vobslprh	195	7	usually	usually	RB
cord-017954-vobslprh	195	8	require	require	VBP
cord-017954-vobslprh	195	9	two	two	CD
cord-017954-vobslprh	195	10	or	or	CC
cord-017954-vobslprh	195	11	three	three	CD
cord-017954-vobslprh	195	12	immunizations	immunization	NNS
cord-017954-vobslprh	195	13	with	with	IN
cord-017954-vobslprh	195	14	AChR	AChR	NNP
cord-017954-vobslprh	195	15	in	in	IN
cord-017954-vobslprh	195	16	complete	complete	JJ
cord-017954-vobslprh	195	17	Freund	Freund	NNP
cord-017954-vobslprh	195	18	's	's	POS
cord-017954-vobslprh	195	19	adjuvant	adjuvant	NN
cord-017954-vobslprh	195	20	.	.	.
cord-017954-vobslprh	196	1	Furthermore	furthermore	RB
cord-017954-vobslprh	196	2	,	,	,
cord-017954-vobslprh	196	3	disease	disease	NN
cord-017954-vobslprh	196	4	severity	severity	NN
cord-017954-vobslprh	196	5	in	in	IN
cord-017954-vobslprh	196	6	mouse	mouse	NN
cord-017954-vobslprh	196	7	EAMG	EAMG	NNP
cord-017954-vobslprh	196	8	is	be	VBZ
cord-017954-vobslprh	196	9	reduced	reduce	VBN
cord-017954-vobslprh	196	10	compared	compare	VBN
cord-017954-vobslprh	196	11	with	with	IN
cord-017954-vobslprh	196	12	the	the	DT
cord-017954-vobslprh	196	13	rat	rat	NN
cord-017954-vobslprh	196	14	model	model	NN
cord-017954-vobslprh	196	15	,	,	,
cord-017954-vobslprh	196	16	and	and	CC
cord-017954-vobslprh	196	17	therefore	therefore	RB
cord-017954-vobslprh	196	18	,	,	,
cord-017954-vobslprh	196	19	this	this	DT
cord-017954-vobslprh	196	20	is	be	VBZ
cord-017954-vobslprh	196	21	an	an	DT
cord-017954-vobslprh	196	22	important	important	JJ
cord-017954-vobslprh	196	23	consideration	consideration	NN
cord-017954-vobslprh	196	24	if	if	IN
cord-017954-vobslprh	196	25	the	the	DT
cord-017954-vobslprh	196	26	efficacy	efficacy	NN
cord-017954-vobslprh	196	27	of	of	IN
cord-017954-vobslprh	196	28	novel	novel	JJ
cord-017954-vobslprh	196	29	therapeutic	therapeutic	JJ
cord-017954-vobslprh	196	30	agents	agent	NNS
cord-017954-vobslprh	196	31	is	be	VBZ
cord-017954-vobslprh	196	32	to	to	TO
cord-017954-vobslprh	196	33	be	be	VB
cord-017954-vobslprh	196	34	tested	test	VBN
cord-017954-vobslprh	196	35	.	.	.
cord-017954-vobslprh	197	1	Of	of	IN
cord-017954-vobslprh	197	2	note	note	NN
cord-017954-vobslprh	197	3	,	,	,
cord-017954-vobslprh	197	4	susceptibility	susceptibility	NN
cord-017954-vobslprh	197	5	to	to	IN
cord-017954-vobslprh	197	6	both	both	CC
cord-017954-vobslprh	197	7	MG	MG	NNP
cord-017954-vobslprh	197	8	and	and	CC
cord-017954-vobslprh	197	9	EAMG	EAMG	NNP
cord-017954-vobslprh	197	10	is	be	VBZ
cord-017954-vobslprh	197	11	linked	link	VBN
cord-017954-vobslprh	197	12	to	to	IN
cord-017954-vobslprh	197	13	the	the	DT
cord-017954-vobslprh	197	14	HLA	HLA	NNP
cord-017954-vobslprh	197	15	/	/	SYM
cord-017954-vobslprh	197	16	MHC	MHC	NNP
cord-017954-vobslprh	197	17	region	region	NN
cord-017954-vobslprh	197	18	[	[	-LRB-
cord-017954-vobslprh	197	19	87	87	CD
cord-017954-vobslprh	197	20	]	]	-RRB-
cord-017954-vobslprh	197	21	.	.	.
cord-017954-vobslprh	198	1	Thus	thus	RB
cord-017954-vobslprh	198	2	,	,	,
cord-017954-vobslprh	198	3	EAMG	EAMG	NNP
cord-017954-vobslprh	198	4	has	have	VBZ
cord-017954-vobslprh	198	5	many	many	JJ
cord-017954-vobslprh	198	6	clinical	clinical	JJ
cord-017954-vobslprh	198	7	and	and	CC
cord-017954-vobslprh	198	8	pathological	pathological	JJ
cord-017954-vobslprh	198	9	similarities	similarity	NNS
cord-017954-vobslprh	198	10	to	to	IN
cord-017954-vobslprh	198	11	human	human	JJ
cord-017954-vobslprh	198	12	MG	MG	NNP
cord-017954-vobslprh	198	13	,	,	,
cord-017954-vobslprh	198	14	especially	especially	RB
cord-017954-vobslprh	198	15	the	the	DT
cord-017954-vobslprh	198	16	presence	presence	NN
cord-017954-vobslprh	198	17	of	of	IN
cord-017954-vobslprh	198	18	autoantibodies	autoantibody	NNS
cord-017954-vobslprh	198	19	that	that	WDT
cord-017954-vobslprh	198	20	recognize	recognize	VBP
cord-017954-vobslprh	198	21	and	and	CC
cord-017954-vobslprh	198	22	bind	bind	VB
cord-017954-vobslprh	198	23	to	to	IN
cord-017954-vobslprh	198	24	AChR.	achr.	NN
cord-017954-vobslprh	199	1	Following	follow	VBG
cord-017954-vobslprh	199	2	immunization	immunization	NN
cord-017954-vobslprh	199	3	,	,	,
cord-017954-vobslprh	199	4	T	t	NN
cord-017954-vobslprh	199	5	cells	cell	NNS
cord-017954-vobslprh	199	6	mediate	mediate	VBP
cord-017954-vobslprh	199	7	the	the	DT
cord-017954-vobslprh	199	8	production	production	NN
cord-017954-vobslprh	199	9	of	of	IN
cord-017954-vobslprh	199	10	AChR	achr	JJ
cord-017954-vobslprh	199	11	-	-	HYPH
cord-017954-vobslprh	199	12	specific	specific	JJ
cord-017954-vobslprh	199	13	antibodies	antibody	NNS
cord-017954-vobslprh	199	14	in	in	IN
cord-017954-vobslprh	199	15	murine	murine	JJ
cord-017954-vobslprh	199	16	EAMG	EAMG	NNP
cord-017954-vobslprh	199	17	as	as	RB
cord-017954-vobslprh	199	18	well	well	RB
cord-017954-vobslprh	199	19	as	as	IN
cord-017954-vobslprh	199	20	human	human	JJ
cord-017954-vobslprh	199	21	MG	MG	NNP
cord-017954-vobslprh	199	22	[	[	-LRB-
cord-017954-vobslprh	199	23	88	88	CD
cord-017954-vobslprh	199	24	]	]	-RRB-
cord-017954-vobslprh	199	25	[	[	-LRB-
cord-017954-vobslprh	199	26	89	89	CD
cord-017954-vobslprh	199	27	]	]	-RRB-
cord-017954-vobslprh	199	28	[	[	-LRB-
cord-017954-vobslprh	199	29	90	90	CD
cord-017954-vobslprh	199	30	]	]	-RRB-
cord-017954-vobslprh	199	31	,	,	,
cord-017954-vobslprh	199	32	and	and	CC
cord-017954-vobslprh	199	33	treatment	treatment	NN
cord-017954-vobslprh	199	34	with	with	IN
cord-017954-vobslprh	199	35	anti	anti	JJ
cord-017954-vobslprh	199	36	-	-	NNP
cord-017954-vobslprh	199	37	CD4	cd4	JJ
cord-017954-vobslprh	199	38	or	or	CC
cord-017954-vobslprh	199	39	anti	anti	NNP
cord-017954-vobslprh	199	40	-	-	JJ
cord-017954-vobslprh	199	41	Ia	Ia	NNP
cord-017954-vobslprh	199	42	antibodies	antibody	NNS
cord-017954-vobslprh	199	43	can	can	MD
cord-017954-vobslprh	199	44	block	block	VB
cord-017954-vobslprh	199	45	the	the	DT
cord-017954-vobslprh	199	46	induction	induction	NN
cord-017954-vobslprh	199	47	or	or	CC
cord-017954-vobslprh	199	48	induce	induce	VB
cord-017954-vobslprh	199	49	remission	remission	NN
cord-017954-vobslprh	199	50	of	of	IN
cord-017954-vobslprh	199	51	EAMG	EAMG	NNP
cord-017954-vobslprh	200	1	[	[	-LRB-
cord-017954-vobslprh	200	2	89	89	CD
cord-017954-vobslprh	200	3	,	,	,
cord-017954-vobslprh	200	4	91	91	CD
cord-017954-vobslprh	200	5	]	]	-RRB-
cord-017954-vobslprh	200	6	.	.	.
cord-017954-vobslprh	201	1	Further	further	JJ
cord-017954-vobslprh	201	2	evidence	evidence	NN
cord-017954-vobslprh	201	3	for	for	IN
cord-017954-vobslprh	201	4	a	a	DT
cord-017954-vobslprh	201	5	role	role	NN
cord-017954-vobslprh	201	6	of	of	IN
cord-017954-vobslprh	201	7	T	T	NNP
cord-017954-vobslprh	201	8	cells	cell	NNS
cord-017954-vobslprh	201	9	in	in	IN
cord-017954-vobslprh	201	10	EAMG	EAMG	NNP
cord-017954-vobslprh	201	11	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	201	12	was	be	VBD
cord-017954-vobslprh	201	13	shown	show	VBN
cord-017954-vobslprh	201	14	by	by	IN
cord-017954-vobslprh	201	15	the	the	DT
cord-017954-vobslprh	201	16	use	use	NN
cord-017954-vobslprh	201	17	of	of	IN
cord-017954-vobslprh	201	18	lymphocyte	lymphocyte	NN
cord-017954-vobslprh	201	19	immunosuppressive	immunosuppressive	JJ
cord-017954-vobslprh	201	20	agents	agent	NNS
cord-017954-vobslprh	201	21	and	and	CC
cord-017954-vobslprh	201	22	oral	oral	JJ
cord-017954-vobslprh	201	23	tolerance	tolerance	NN
cord-017954-vobslprh	201	24	to	to	IN
cord-017954-vobslprh	201	25	AChR	AChR	NNP
cord-017954-vobslprh	202	1	that	that	DT
cord-017954-vobslprh	202	2	inhibited	inhibited	JJ
cord-017954-vobslprh	202	3	disease	disease	NN
cord-017954-vobslprh	202	4	onset	onset	NN
cord-017954-vobslprh	202	5	[	[	-LRB-
cord-017954-vobslprh	202	6	92	92	CD
cord-017954-vobslprh	202	7	]	]	-RRB-
cord-017954-vobslprh	202	8	[	[	-LRB-
cord-017954-vobslprh	202	9	93	93	CD
cord-017954-vobslprh	202	10	]	]	-RRB-
cord-017954-vobslprh	202	11	[	[	-LRB-
cord-017954-vobslprh	202	12	94	94	CD
cord-017954-vobslprh	202	13	]	]	-RRB-
cord-017954-vobslprh	202	14	.	.	.
cord-017954-vobslprh	203	1	Similar	similar	JJ
cord-017954-vobslprh	203	2	to	to	IN
cord-017954-vobslprh	203	3	that	that	DT
cord-017954-vobslprh	203	4	observed	observe	VBN
cord-017954-vobslprh	203	5	in	in	IN
cord-017954-vobslprh	203	6	EAE	EAE	NNP
cord-017954-vobslprh	203	7	,	,	,
cord-017954-vobslprh	203	8	the	the	DT
cord-017954-vobslprh	203	9	role	role	NN
cord-017954-vobslprh	203	10	of	of	IN
cord-017954-vobslprh	203	11	pro	pro	JJ
cord-017954-vobslprh	203	12	-	-	JJ
cord-017954-vobslprh	203	13	inflammatory	inflammatory	JJ
cord-017954-vobslprh	203	14	cytokines	cytokine	NNS
cord-017954-vobslprh	203	15	including	include	VBG
cord-017954-vobslprh	203	16	IL-1	IL-1	NNP
cord-017954-vobslprh	203	17	,	,	,
cord-017954-vobslprh	203	18	IL-12	IL-12	NNP
cord-017954-vobslprh	203	19	,	,	,
cord-017954-vobslprh	203	20	IFN	IFN	NNP
cord-017954-vobslprh	203	21	-	-	HYPH
cord-017954-vobslprh	203	22	γ	γ	NNP
cord-017954-vobslprh	203	23	,	,	,
cord-017954-vobslprh	203	24	and	and	CC
cord-017954-vobslprh	203	25	TNF	TNF	NNP
cord-017954-vobslprh	203	26	-	-	HYPH
cord-017954-vobslprh	203	27	α	α	NNP
cord-017954-vobslprh	203	28	is	be	VBZ
cord-017954-vobslprh	203	29	also	also	RB
cord-017954-vobslprh	203	30	important	important	JJ
cord-017954-vobslprh	203	31	in	in	IN
cord-017954-vobslprh	203	32	the	the	DT
cord-017954-vobslprh	203	33	onset	onset	NN
cord-017954-vobslprh	203	34	of	of	IN
cord-017954-vobslprh	203	35	EAMG	EAMG	NNP
cord-017954-vobslprh	203	36	,	,	,
cord-017954-vobslprh	203	37	with	with	IN
cord-017954-vobslprh	203	38	functions	function	NNS
cord-017954-vobslprh	203	39	related	relate	VBN
cord-017954-vobslprh	203	40	to	to	IN
cord-017954-vobslprh	203	41	T	t	NN
cord-017954-vobslprh	203	42	-	-	HYPH
cord-017954-vobslprh	203	43	cell	cell	NN
cord-017954-vobslprh	203	44	development	development	NN
cord-017954-vobslprh	203	45	,	,	,
cord-017954-vobslprh	203	46	proliferation	proliferation	NN
cord-017954-vobslprh	203	47	,	,	,
cord-017954-vobslprh	203	48	and	and	CC
cord-017954-vobslprh	203	49	differentiation	differentiation	NN
cord-017954-vobslprh	203	50	.	.	.
cord-017954-vobslprh	204	1	Studies	study	NNS
cord-017954-vobslprh	204	2	in	in	IN
cord-017954-vobslprh	204	3	EAMG	EAMG	NNP
cord-017954-vobslprh	204	4	demonstrated	demonstrate	VBD
cord-017954-vobslprh	204	5	that	that	IN
cord-017954-vobslprh	204	6	treatment	treatment	NN
cord-017954-vobslprh	204	7	of	of	IN
cord-017954-vobslprh	204	8	EAMG	EAMG	NNP
cord-017954-vobslprh	204	9	rats	rat	NNS
cord-017954-vobslprh	204	10	or	or	CC
cord-017954-vobslprh	204	11	mice	mouse	NNS
cord-017954-vobslprh	204	12	with	with	IN
cord-017954-vobslprh	204	13	anti	anti	JJ
cord-017954-vobslprh	204	14	-	-	JJ
cord-017954-vobslprh	204	15	TNF	TNF	NNP
cord-017954-vobslprh	204	16	-	-	HYPH
cord-017954-vobslprh	204	17	α	α	NN
cord-017954-vobslprh	204	18	treatments	treatment	NNS
cord-017954-vobslprh	204	19	reduced	reduce	VBD
cord-017954-vobslprh	204	20	EAMG	EAMG	NNP
cord-017954-vobslprh	204	21	development	development	NN
cord-017954-vobslprh	204	22	[	[	-LRB-
cord-017954-vobslprh	204	23	95	95	CD
cord-017954-vobslprh	204	24	]	]	-RRB-
cord-017954-vobslprh	204	25	and	and	CC
cord-017954-vobslprh	204	26	significantly	significantly	RB
cord-017954-vobslprh	204	27	improved	improve	VBD
cord-017954-vobslprh	204	28	established	establish	VBN
cord-017954-vobslprh	204	29	disease	disease	NN
cord-017954-vobslprh	204	30	[	[	-LRB-
cord-017954-vobslprh	204	31	96	96	CD
cord-017954-vobslprh	204	32	]	]	-RRB-
cord-017954-vobslprh	204	33	.	.	.
cord-017954-vobslprh	205	1	Confirmation	confirmation	NN
cord-017954-vobslprh	205	2	of	of	IN
cord-017954-vobslprh	205	3	a	a	DT
cord-017954-vobslprh	205	4	role	role	NN
cord-017954-vobslprh	205	5	for	for	IN
cord-017954-vobslprh	205	6	TNF	TNF	NNP
cord-017954-vobslprh	205	7	in	in	IN
cord-017954-vobslprh	205	8	MG	MG	NNP
cord-017954-vobslprh	205	9	was	be	VBD
cord-017954-vobslprh	205	10	demonstrated	demonstrate	VBN
cord-017954-vobslprh	205	11	by	by	IN
cord-017954-vobslprh	205	12	a	a	DT
cord-017954-vobslprh	205	13	trial	trial	NN
cord-017954-vobslprh	205	14	investigating	investigate	VBG
cord-017954-vobslprh	205	15	the	the	DT
cord-017954-vobslprh	205	16	use	use	NN
cord-017954-vobslprh	205	17	of	of	IN
cord-017954-vobslprh	205	18	a	a	DT
cord-017954-vobslprh	205	19	TNF	TNF	NNP
cord-017954-vobslprh	205	20	inhibitor	inhibitor	NN
cord-017954-vobslprh	205	21	(	(	-LRB-
cord-017954-vobslprh	205	22	etanercept	etanercept	NNP
cord-017954-vobslprh	205	23	)	)	-RRB-
cord-017954-vobslprh	205	24	in	in	IN
cord-017954-vobslprh	205	25	MG	MG	NNP
cord-017954-vobslprh	205	26	patients	patient	NNS
cord-017954-vobslprh	205	27	that	that	IN
cord-017954-vobslprh	205	28	reduced	reduce	VBN
cord-017954-vobslprh	205	29	muscle	muscle	NN
cord-017954-vobslprh	205	30	weakness	weakness	NN
cord-017954-vobslprh	205	31	[	[	-LRB-
cord-017954-vobslprh	205	32	97	97	CD
cord-017954-vobslprh	205	33	]	]	-RRB-
cord-017954-vobslprh	205	34	.	.	.
cord-017954-vobslprh	206	1	Once	once	IN
cord-017954-vobslprh	206	2	the	the	DT
cord-017954-vobslprh	206	3	autoreactive	autoreactive	JJ
cord-017954-vobslprh	206	4	T	t	NN
cord-017954-vobslprh	206	5	cells	cell	NNS
cord-017954-vobslprh	206	6	become	become	VBP
cord-017954-vobslprh	206	7	activated	activate	VBN
cord-017954-vobslprh	206	8	,	,	,
cord-017954-vobslprh	206	9	they	-PRON-	PRP
cord-017954-vobslprh	206	10	stimulate	stimulate	VBP
cord-017954-vobslprh	206	11	B	b	NN
cord-017954-vobslprh	206	12	cells	cell	NNS
cord-017954-vobslprh	206	13	to	to	TO
cord-017954-vobslprh	206	14	produce	produce	VB
cord-017954-vobslprh	206	15	and	and	CC
cord-017954-vobslprh	206	16	secrete	secrete	VB
cord-017954-vobslprh	206	17	anti	anti	JJ
cord-017954-vobslprh	206	18	-	-	JJ
cord-017954-vobslprh	206	19	AChR	achr	JJ
cord-017954-vobslprh	206	20	antibodies	antibody	NNS
cord-017954-vobslprh	206	21	that	that	WDT
cord-017954-vobslprh	206	22	induce	induce	VBP
cord-017954-vobslprh	206	23	the	the	DT
cord-017954-vobslprh	206	24	observed	observed	JJ
cord-017954-vobslprh	206	25	clinical	clinical	JJ
cord-017954-vobslprh	206	26	symptoms	symptom	NNS
cord-017954-vobslprh	206	27	.	.	.
cord-017954-vobslprh	207	1	EAMG	EAMG	NNP
cord-017954-vobslprh	207	2	studies	study	NNS
cord-017954-vobslprh	207	3	have	have	VBP
cord-017954-vobslprh	207	4	indicated	indicate	VBN
cord-017954-vobslprh	207	5	that	that	IN
cord-017954-vobslprh	207	6	following	follow	VBG
cord-017954-vobslprh	207	7	the	the	DT
cord-017954-vobslprh	207	8	binding	binding	NN
cord-017954-vobslprh	207	9	of	of	IN
cord-017954-vobslprh	207	10	AChR	achr	JJ
cord-017954-vobslprh	207	11	antibodies	antibody	NNS
cord-017954-vobslprh	207	12	to	to	IN
cord-017954-vobslprh	207	13	NMJs	nmj	NNS
cord-017954-vobslprh	207	14	,	,	,
cord-017954-vobslprh	207	15	complement	complement	NN
cord-017954-vobslprh	207	16	activation	activation	NN
cord-017954-vobslprh	207	17	including	include	VBG
cord-017954-vobslprh	207	18	C3	C3	NNP
cord-017954-vobslprh	207	19	and	and	CC
cord-017954-vobslprh	207	20	C9	C9	NNP
cord-017954-vobslprh	207	21	deposition	deposition	NN
cord-017954-vobslprh	207	22	and	and	CC
cord-017954-vobslprh	207	23	membrane	membrane	NN
cord-017954-vobslprh	207	24	attack	attack	NN
cord-017954-vobslprh	207	25	complex	complex	NN
cord-017954-vobslprh	207	26	might	may	MD
cord-017954-vobslprh	207	27	mediate	mediate	VB
cord-017954-vobslprh	207	28	the	the	DT
cord-017954-vobslprh	207	29	destruction	destruction	NN
cord-017954-vobslprh	207	30	of	of	IN
cord-017954-vobslprh	207	31	NMJ	NMJ	NNP
cord-017954-vobslprh	207	32	plasma	plasma	NN
cord-017954-vobslprh	207	33	membranes	membrane	NNS
cord-017954-vobslprh	207	34	[	[	-LRB-
cord-017954-vobslprh	207	35	98	98	CD
cord-017954-vobslprh	207	36	]	]	-RRB-
cord-017954-vobslprh	207	37	[	[	-LRB-
cord-017954-vobslprh	207	38	99	99	CD
cord-017954-vobslprh	207	39	]	]	-RRB-
cord-017954-vobslprh	207	40	[	[	-LRB-
cord-017954-vobslprh	207	41	100	100	CD
cord-017954-vobslprh	207	42	]	]	-RRB-
cord-017954-vobslprh	207	43	.	.	.
cord-017954-vobslprh	208	1	Confirmation	confirmation	NN
cord-017954-vobslprh	208	2	of	of	IN
cord-017954-vobslprh	208	3	a	a	DT
cord-017954-vobslprh	208	4	role	role	NN
cord-017954-vobslprh	208	5	for	for	IN
cord-017954-vobslprh	208	6	complement	complement	NN
cord-017954-vobslprh	208	7	in	in	IN
cord-017954-vobslprh	208	8	EAMG	EAMG	NNP
cord-017954-vobslprh	208	9	was	be	VBD
cord-017954-vobslprh	208	10	shown	show	VBN
cord-017954-vobslprh	208	11	in	in	IN
cord-017954-vobslprh	208	12	studies	study	NNS
cord-017954-vobslprh	208	13	reporting	report	VBG
cord-017954-vobslprh	208	14	that	that	IN
cord-017954-vobslprh	208	15	the	the	DT
cord-017954-vobslprh	208	16	blockade	blockade	NN
cord-017954-vobslprh	208	17	of	of	IN
cord-017954-vobslprh	208	18	the	the	DT
cord-017954-vobslprh	208	19	complement	complement	JJ
cord-017954-vobslprh	208	20	system	system	NN
cord-017954-vobslprh	208	21	by	by	IN
cord-017954-vobslprh	208	22	complement	complement	NN
cord-017954-vobslprh	208	23	inhibitors	inhibitor	NNS
cord-017954-vobslprh	208	24	protected	protect	VBD
cord-017954-vobslprh	208	25	rats	rat	NNS
cord-017954-vobslprh	208	26	against	against	IN
cord-017954-vobslprh	208	27	the	the	DT
cord-017954-vobslprh	208	28	induction	induction	NN
cord-017954-vobslprh	208	29	of	of	IN
cord-017954-vobslprh	208	30	EAMG	EAMG	NNP
cord-017954-vobslprh	208	31	[	[	-LRB-
cord-017954-vobslprh	208	32	101	101	CD
cord-017954-vobslprh	208	33	]	]	-RRB-
cord-017954-vobslprh	208	34	[	[	-LRB-
cord-017954-vobslprh	208	35	102	102	CD
cord-017954-vobslprh	208	36	]	]	-RRB-
cord-017954-vobslprh	208	37	[	[	-LRB-
cord-017954-vobslprh	208	38	103	103	CD
cord-017954-vobslprh	208	39	]	]	-RRB-
cord-017954-vobslprh	208	40	.	.	.
cord-017954-vobslprh	209	1	Importantly	importantly	RB
cord-017954-vobslprh	209	2	,	,	,
cord-017954-vobslprh	209	3	the	the	DT
cord-017954-vobslprh	209	4	role	role	NN
cord-017954-vobslprh	209	5	of	of	IN
cord-017954-vobslprh	209	6	complement	complement	NN
cord-017954-vobslprh	209	7	was	be	VBD
cord-017954-vobslprh	209	8	indicated	indicate	VBN
cord-017954-vobslprh	209	9	in	in	IN
cord-017954-vobslprh	209	10	human	human	JJ
cord-017954-vobslprh	209	11	MG	MG	NNP
cord-017954-vobslprh	209	12	[	[	-LRB-
cord-017954-vobslprh	209	13	99	99	CD
cord-017954-vobslprh	209	14	,	,	,
cord-017954-vobslprh	209	15	100	100	CD
cord-017954-vobslprh	209	16	,	,	,
cord-017954-vobslprh	209	17	104	104	CD
cord-017954-vobslprh	209	18	]	]	-RRB-
cord-017954-vobslprh	209	19	,	,	,
cord-017954-vobslprh	209	20	indicating	indicate	VBG
cord-017954-vobslprh	209	21	the	the	DT
cord-017954-vobslprh	209	22	validity	validity	NN
cord-017954-vobslprh	209	23	of	of	IN
cord-017954-vobslprh	209	24	EAMG	EAMG	NNP
cord-017954-vobslprh	209	25	.	.	.
cord-017954-vobslprh	210	1	Clinical	clinical	JJ
cord-017954-vobslprh	210	2	signs	sign	NNS
cord-017954-vobslprh	210	3	of	of	IN
cord-017954-vobslprh	210	4	active	active	JJ
cord-017954-vobslprh	210	5	EAMG	EAMG	NNP
cord-017954-vobslprh	210	6	(	(	-LRB-
cord-017954-vobslprh	210	7	tremor	tremor	NN
cord-017954-vobslprh	210	8	,	,	,
cord-017954-vobslprh	210	9	hunched	hunch	VBN
cord-017954-vobslprh	210	10	posture	posture	NN
cord-017954-vobslprh	210	11	,	,	,
cord-017954-vobslprh	210	12	muscle	muscle	NN
cord-017954-vobslprh	210	13	weakness	weakness	NN
cord-017954-vobslprh	210	14	,	,	,
cord-017954-vobslprh	210	15	and	and	CC
cord-017954-vobslprh	210	16	fatigue	fatigue	NN
cord-017954-vobslprh	210	17	)	)	-RRB-
cord-017954-vobslprh	210	18	usually	usually	RB
cord-017954-vobslprh	210	19	occur	occur	VBP
cord-017954-vobslprh	210	20	3	3	CD
cord-017954-vobslprh	210	21	-	-	SYM
cord-017954-vobslprh	210	22	10	10	CD
cord-017954-vobslprh	210	23	days	day	NNS
cord-017954-vobslprh	210	24	after	after	IN
cord-017954-vobslprh	210	25	the	the	DT
cord-017954-vobslprh	210	26	second	second	JJ
cord-017954-vobslprh	210	27	immunization	immunization	NN
cord-017954-vobslprh	210	28	,	,	,
cord-017954-vobslprh	210	29	and	and	CC
cord-017954-vobslprh	210	30	mice	mouse	NNS
cord-017954-vobslprh	210	31	are	be	VBP
cord-017954-vobslprh	210	32	observed	observe	VBN
cord-017954-vobslprh	210	33	for	for	IN
cord-017954-vobslprh	210	34	signs	sign	NNS
cord-017954-vobslprh	210	35	of	of	IN
cord-017954-vobslprh	210	36	muscle	muscle	NN
cord-017954-vobslprh	210	37	weakness	weakness	NN
cord-017954-vobslprh	210	38	by	by	IN
cord-017954-vobslprh	210	39	the	the	DT
cord-017954-vobslprh	210	40	paw	paw	NN
cord-017954-vobslprh	210	41	-	-	HYPH
cord-017954-vobslprh	210	42	grip	grip	NN
cord-017954-vobslprh	210	43	test	test	NN
cord-017954-vobslprh	210	44	at	at	IN
cord-017954-vobslprh	210	45	least	least	JJS
cord-017954-vobslprh	210	46	once	once	RB
cord-017954-vobslprh	210	47	a	a	DT
cord-017954-vobslprh	210	48	week	week	NN
cord-017954-vobslprh	210	49	.	.	.
cord-017954-vobslprh	211	1	In	in	IN
cord-017954-vobslprh	211	2	addition	addition	NN
cord-017954-vobslprh	211	3	,	,	,
cord-017954-vobslprh	211	4	a	a	DT
cord-017954-vobslprh	211	5	number	number	NN
cord-017954-vobslprh	211	6	of	of	IN
cord-017954-vobslprh	211	7	other	other	JJ
cord-017954-vobslprh	211	8	tests	test	NNS
cord-017954-vobslprh	211	9	have	have	VBP
cord-017954-vobslprh	211	10	been	be	VBN
cord-017954-vobslprh	211	11	developed	develop	VBN
cord-017954-vobslprh	211	12	to	to	TO
cord-017954-vobslprh	211	13	assess	assess	VB
cord-017954-vobslprh	211	14	the	the	DT
cord-017954-vobslprh	211	15	extent	extent	NN
cord-017954-vobslprh	211	16	of	of	IN
cord-017954-vobslprh	211	17	disease	disease	NN
cord-017954-vobslprh	211	18	including	include	VBG
cord-017954-vobslprh	211	19	the	the	DT
cord-017954-vobslprh	211	20	quantitative	quantitative	JJ
cord-017954-vobslprh	211	21	measurement	measurement	NN
cord-017954-vobslprh	211	22	of	of	IN
cord-017954-vobslprh	211	23	muscle	muscle	NN
cord-017954-vobslprh	211	24	weakness	weakness	NN
cord-017954-vobslprh	211	25	by	by	IN
cord-017954-vobslprh	211	26	electromyography	electromyography	NN
cord-017954-vobslprh	211	27	,	,	,
cord-017954-vobslprh	211	28	the	the	DT
cord-017954-vobslprh	211	29	evaluation	evaluation	NN
cord-017954-vobslprh	211	30	of	of	IN
cord-017954-vobslprh	211	31	EAMG	EAMG	NNP
cord-017954-vobslprh	211	32	induction	induction	NN
cord-017954-vobslprh	211	33	by	by	IN
cord-017954-vobslprh	211	34	the	the	DT
cord-017954-vobslprh	211	35	quantification	quantification	NN
cord-017954-vobslprh	211	36	of	of	IN
cord-017954-vobslprh	211	37	muscle	muscle	NN
cord-017954-vobslprh	211	38	AChR	AChR	NNP
cord-017954-vobslprh	211	39	loss	loss	NN
cord-017954-vobslprh	211	40	,	,	,
cord-017954-vobslprh	211	41	and	and	CC
cord-017954-vobslprh	211	42	serum	serum	NN
cord-017954-vobslprh	211	43	anti	anti	JJ
cord-017954-vobslprh	211	44	-	-	JJ
cord-017954-vobslprh	211	45	AChR	achr	JJ
cord-017954-vobslprh	211	46	antibody	antibody	NN
cord-017954-vobslprh	211	47	levels	level	NNS
cord-017954-vobslprh	211	48	by	by	IN
cord-017954-vobslprh	211	49	radioimmunoassay	radioimmunoassay	JJ
cord-017954-vobslprh	211	50	or	or	CC
cord-017954-vobslprh	211	51	ELISA	ELISA	NNP
cord-017954-vobslprh	211	52	.	.	.
cord-017954-vobslprh	212	1	Therefore	therefore	RB
cord-017954-vobslprh	212	2	,	,	,
cord-017954-vobslprh	212	3	active	active	JJ
cord-017954-vobslprh	212	4	EAMG	EAMG	NNP
cord-017954-vobslprh	212	5	is	be	VBZ
cord-017954-vobslprh	212	6	a	a	DT
cord-017954-vobslprh	212	7	useful	useful	JJ
cord-017954-vobslprh	212	8	model	model	NN
cord-017954-vobslprh	212	9	for	for	IN
cord-017954-vobslprh	212	10	myasthenia	myasthenia	NN
cord-017954-vobslprh	212	11	gravis	gravis	NNP
cord-017954-vobslprh	212	12	and	and	CC
cord-017954-vobslprh	212	13	the	the	DT
cord-017954-vobslprh	212	14	extent	extent	NN
cord-017954-vobslprh	212	15	of	of	IN
cord-017954-vobslprh	212	16	disease	disease	NN
cord-017954-vobslprh	212	17	can	can	MD
cord-017954-vobslprh	212	18	be	be	VB
cord-017954-vobslprh	212	19	measured	measure	VBN
cord-017954-vobslprh	212	20	using	use	VBG
cord-017954-vobslprh	212	21	fairly	fairly	RB
cord-017954-vobslprh	212	22	noninvasive	noninvasive	JJ
cord-017954-vobslprh	212	23	techniques	technique	NNS
cord-017954-vobslprh	212	24	.	.	.
cord-017954-vobslprh	213	1	Another	another	DT
cord-017954-vobslprh	213	2	method	method	NN
cord-017954-vobslprh	213	3	for	for	IN
cord-017954-vobslprh	213	4	the	the	DT
cord-017954-vobslprh	213	5	induction	induction	NN
cord-017954-vobslprh	213	6	of	of	IN
cord-017954-vobslprh	213	7	EAMG	EAMG	NNP
cord-017954-vobslprh	213	8	is	be	VBZ
cord-017954-vobslprh	213	9	the	the	DT
cord-017954-vobslprh	213	10	passive	passive	JJ
cord-017954-vobslprh	213	11	transfer	transfer	NN
cord-017954-vobslprh	213	12	model	model	NN
cord-017954-vobslprh	213	13	,	,	,
cord-017954-vobslprh	213	14	where	where	WRB
cord-017954-vobslprh	213	15	autoantibodies	autoantibody	NNS
cord-017954-vobslprh	213	16	specific	specific	JJ
cord-017954-vobslprh	213	17	for	for	IN
cord-017954-vobslprh	213	18	AChR	AChR	NNP
cord-017954-vobslprh	213	19	from	from	IN
cord-017954-vobslprh	213	20	donor	donor	NN
cord-017954-vobslprh	214	1	AChR	achr	JJ
cord-017954-vobslprh	214	2	-	-	HYPH
cord-017954-vobslprh	214	3	immunized	immunize	VBN
cord-017954-vobslprh	214	4	animals	animal	NNS
cord-017954-vobslprh	214	5	are	be	VBP
cord-017954-vobslprh	214	6	injected	inject	VBN
cord-017954-vobslprh	214	7	daily	daily	RB
cord-017954-vobslprh	214	8	into	into	IN
cord-017954-vobslprh	214	9	naïve	naïve	JJ
cord-017954-vobslprh	214	10	animals	animal	NNS
cord-017954-vobslprh	214	11	,	,	,
cord-017954-vobslprh	214	12	and	and	CC
cord-017954-vobslprh	214	13	this	this	DT
cord-017954-vobslprh	214	14	was	be	VBD
cord-017954-vobslprh	214	15	first	first	RB
cord-017954-vobslprh	214	16	shown	show	VBN
cord-017954-vobslprh	214	17	in	in	IN
cord-017954-vobslprh	214	18	a	a	DT
cord-017954-vobslprh	214	19	rat	rat	NN
cord-017954-vobslprh	214	20	model	model	NN
cord-017954-vobslprh	214	21	[	[	-LRB-
cord-017954-vobslprh	214	22	83	83	CD
cord-017954-vobslprh	214	23	,	,	,
cord-017954-vobslprh	214	24	105	105	CD
cord-017954-vobslprh	214	25	]	]	-RRB-
cord-017954-vobslprh	214	26	.	.	.
cord-017954-vobslprh	215	1	Another	another	DT
cord-017954-vobslprh	215	2	method	method	NN
cord-017954-vobslprh	215	3	for	for	IN
cord-017954-vobslprh	215	4	the	the	DT
cord-017954-vobslprh	215	5	passive	passive	JJ
cord-017954-vobslprh	215	6	induction	induction	NN
cord-017954-vobslprh	215	7	of	of	IN
cord-017954-vobslprh	215	8	EAMG	EAMG	NNP
cord-017954-vobslprh	215	9	is	be	VBZ
cord-017954-vobslprh	215	10	the	the	DT
cord-017954-vobslprh	215	11	injection	injection	NN
cord-017954-vobslprh	215	12	of	of	IN
cord-017954-vobslprh	215	13	AChR	achr	JJ
cord-017954-vobslprh	215	14	-	-	HYPH
cord-017954-vobslprh	215	15	specific	specific	JJ
cord-017954-vobslprh	215	16	antibodies	antibody	NNS
cord-017954-vobslprh	215	17	isolated	isolate	VBN
cord-017954-vobslprh	215	18	from	from	IN
cord-017954-vobslprh	215	19	the	the	DT
cord-017954-vobslprh	215	20	serum	serum	NN
cord-017954-vobslprh	215	21	of	of	IN
cord-017954-vobslprh	215	22	MG	MG	NNP
cord-017954-vobslprh	215	23	patients	patient	NNS
cord-017954-vobslprh	215	24	[	[	-LRB-
cord-017954-vobslprh	215	25	106	106	CD
cord-017954-vobslprh	215	26	]	]	-RRB-
cord-017954-vobslprh	215	27	.	.	.
cord-017954-vobslprh	216	1	Interestingly	interestingly	RB
cord-017954-vobslprh	216	2	,	,	,
cord-017954-vobslprh	216	3	the	the	DT
cord-017954-vobslprh	216	4	transfer	transfer	NN
cord-017954-vobslprh	216	5	of	of	IN
cord-017954-vobslprh	216	6	EAMG	EAMG	NNP
cord-017954-vobslprh	216	7	by	by	IN
cord-017954-vobslprh	216	8	autoreactive	autoreactive	JJ
cord-017954-vobslprh	216	9	lymphocytes	lymphocyte	NNS
cord-017954-vobslprh	216	10	is	be	VBZ
cord-017954-vobslprh	216	11	less	less	RBR
cord-017954-vobslprh	216	12	robust	robust	JJ
cord-017954-vobslprh	216	13	than	than	IN
cord-017954-vobslprh	216	14	that	that	DT
cord-017954-vobslprh	216	15	by	by	IN
cord-017954-vobslprh	216	16	autoantibodies	autoantibody	NNS
cord-017954-vobslprh	216	17	[	[	-LRB-
cord-017954-vobslprh	216	18	107	107	CD
cord-017954-vobslprh	216	19	]	]	-RRB-
cord-017954-vobslprh	216	20	and	and	CC
cord-017954-vobslprh	216	21	indicates	indicate	VBZ
cord-017954-vobslprh	216	22	that	that	IN
cord-017954-vobslprh	216	23	autoreactive	autoreactive	JJ
cord-017954-vobslprh	216	24	antibodies	antibody	NNS
cord-017954-vobslprh	216	25	are	be	VBP
cord-017954-vobslprh	216	26	probably	probably	RB
cord-017954-vobslprh	216	27	the	the	DT
cord-017954-vobslprh	216	28	major	major	JJ
cord-017954-vobslprh	216	29	mechanism	mechanism	NN
cord-017954-vobslprh	216	30	involved	involve	VBN
cord-017954-vobslprh	216	31	in	in	IN
cord-017954-vobslprh	216	32	the	the	DT
cord-017954-vobslprh	216	33	onset	onset	NN
cord-017954-vobslprh	216	34	of	of	IN
cord-017954-vobslprh	216	35	NMJ	NMJ	NNP
cord-017954-vobslprh	216	36	destruction	destruction	NN
cord-017954-vobslprh	216	37	.	.	.
cord-017954-vobslprh	217	1	In	in	IN
cord-017954-vobslprh	217	2	summary	summary	NN
cord-017954-vobslprh	217	3	,	,	,
cord-017954-vobslprh	217	4	active	active	JJ
cord-017954-vobslprh	217	5	EAMG	EAMG	NNP
cord-017954-vobslprh	217	6	is	be	VBZ
cord-017954-vobslprh	217	7	useful	useful	JJ
cord-017954-vobslprh	217	8	for	for	IN
cord-017954-vobslprh	217	9	investigating	investigate	VBG
cord-017954-vobslprh	217	10	the	the	DT
cord-017954-vobslprh	217	11	induction	induction	NN
cord-017954-vobslprh	217	12	phase	phase	NN
cord-017954-vobslprh	217	13	of	of	IN
cord-017954-vobslprh	217	14	disease	disease	NN
cord-017954-vobslprh	217	15	(	(	-LRB-
cord-017954-vobslprh	217	16	T	T	NNP
cord-017954-vobslprh	217	17	-	-	HYPH
cord-017954-vobslprh	217	18	and	and	CC
cord-017954-vobslprh	217	19	B	b	NN
cord-017954-vobslprh	217	20	-	-	HYPH
cord-017954-vobslprh	217	21	cell	cell	NN
cord-017954-vobslprh	217	22	activation	activation	NN
cord-017954-vobslprh	217	23	and	and	CC
cord-017954-vobslprh	217	24	autoantibody	autoantibody	NNP
cord-017954-vobslprh	217	25	production	production	NN
cord-017954-vobslprh	217	26	)	)	-RRB-
cord-017954-vobslprh	217	27	including	include	VBG
cord-017954-vobslprh	217	28	loss	loss	NN
cord-017954-vobslprh	217	29	of	of	IN
cord-017954-vobslprh	217	30	selftolerance	selftolerance	NN
cord-017954-vobslprh	217	31	,	,	,
cord-017954-vobslprh	217	32	mechanisms	mechanism	NNS
cord-017954-vobslprh	217	33	of	of	IN
cord-017954-vobslprh	217	34	antigen	antigen	NN
cord-017954-vobslprh	217	35	-	-	HYPH
cord-017954-vobslprh	217	36	specific	specific	JJ
cord-017954-vobslprh	217	37	immune	immune	JJ
cord-017954-vobslprh	217	38	response	response	NN
cord-017954-vobslprh	217	39	induction	induction	NN
cord-017954-vobslprh	217	40	,	,	,
cord-017954-vobslprh	217	41	and	and	CC
cord-017954-vobslprh	217	42	their	-PRON-	PRP$
cord-017954-vobslprh	217	43	modulation	modulation	NN
cord-017954-vobslprh	217	44	by	by	IN
cord-017954-vobslprh	217	45	therapeutic	therapeutic	JJ
cord-017954-vobslprh	217	46	agents	agent	NNS
cord-017954-vobslprh	217	47	(	(	-LRB-
cord-017954-vobslprh	217	48	to	to	TO
cord-017954-vobslprh	217	49	induce	induce	VB
cord-017954-vobslprh	217	50	tolerance	tolerance	NN
cord-017954-vobslprh	217	51	or	or	CC
cord-017954-vobslprh	217	52	immunosuppression	immunosuppression	NN
cord-017954-vobslprh	217	53	)	)	-RRB-
cord-017954-vobslprh	217	54	,	,	,
cord-017954-vobslprh	217	55	whereas	whereas	IN
cord-017954-vobslprh	217	56	passive	passive	JJ
cord-017954-vobslprh	217	57	EAMG	EAMG	NNP
cord-017954-vobslprh	217	58	is	be	VBZ
cord-017954-vobslprh	217	59	useful	useful	JJ
cord-017954-vobslprh	217	60	for	for	IN
cord-017954-vobslprh	217	61	the	the	DT
cord-017954-vobslprh	217	62	study	study	NN
cord-017954-vobslprh	217	63	of	of	IN
cord-017954-vobslprh	217	64	the	the	DT
cord-017954-vobslprh	217	65	effector	effector	JJ
cord-017954-vobslprh	217	66	phase	phase	NN
cord-017954-vobslprh	217	67	of	of	IN
cord-017954-vobslprh	217	68	disease	disease	NN
cord-017954-vobslprh	217	69	including	include	VBG
cord-017954-vobslprh	217	70	IgG	IgG	NNP
cord-017954-vobslprh	217	71	deposition	deposition	NN
cord-017954-vobslprh	217	72	in	in	IN
cord-017954-vobslprh	217	73	NMJs	nmjs	NN
cord-017954-vobslprh	217	74	,	,	,
cord-017954-vobslprh	217	75	complement	complement	NN
cord-017954-vobslprh	217	76	molecules	molecule	NNS
cord-017954-vobslprh	217	77	,	,	,
cord-017954-vobslprh	217	78	and	and	CC
cord-017954-vobslprh	217	79	investigating	investigate	VBG
cord-017954-vobslprh	217	80	treatments	treatment	NNS
cord-017954-vobslprh	217	81	using	use	VBG
cord-017954-vobslprh	217	82	regulatory	regulatory	JJ
cord-017954-vobslprh	217	83	proteins	protein	NNS
cord-017954-vobslprh	217	84	to	to	TO
cord-017954-vobslprh	217	85	prevent	prevent	VB
cord-017954-vobslprh	217	86	the	the	DT
cord-017954-vobslprh	217	87	degradation	degradation	NN
cord-017954-vobslprh	217	88	of	of	IN
cord-017954-vobslprh	217	89	NMJs	nmj	NNS
cord-017954-vobslprh	217	90	.	.	.
cord-017954-vobslprh	218	1	Clinical	clinical	JJ
cord-017954-vobslprh	218	2	disease	disease	NN
cord-017954-vobslprh	218	3	in	in	IN
cord-017954-vobslprh	218	4	the	the	DT
cord-017954-vobslprh	218	5	passive	passive	JJ
cord-017954-vobslprh	218	6	model	model	NN
cord-017954-vobslprh	218	7	of	of	IN
cord-017954-vobslprh	218	8	EAMG	EAMG	NNP
cord-017954-vobslprh	218	9	is	be	VBZ
cord-017954-vobslprh	218	10	similar	similar	JJ
cord-017954-vobslprh	218	11	to	to	IN
cord-017954-vobslprh	218	12	that	that	DT
cord-017954-vobslprh	218	13	observed	observe	VBN
cord-017954-vobslprh	218	14	in	in	IN
cord-017954-vobslprh	218	15	active	active	JJ
cord-017954-vobslprh	218	16	EAMG	EAMG	NNP
cord-017954-vobslprh	218	17	and	and	CC
cord-017954-vobslprh	218	18	therefore	therefore	RB
cord-017954-vobslprh	218	19	serves	serve	VBZ
cord-017954-vobslprh	218	20	as	as	IN
cord-017954-vobslprh	218	21	a	a	DT
cord-017954-vobslprh	218	22	useful	useful	JJ
cord-017954-vobslprh	218	23	model	model	NN
cord-017954-vobslprh	218	24	of	of	IN
cord-017954-vobslprh	218	25	MG	MG	NNP
cord-017954-vobslprh	218	26	when	when	WRB
cord-017954-vobslprh	218	27	full	full	JJ
cord-017954-vobslprh	218	28	activation	activation	NN
cord-017954-vobslprh	218	29	of	of	IN
cord-017954-vobslprh	218	30	the	the	DT
cord-017954-vobslprh	218	31	immune	immune	JJ
cord-017954-vobslprh	218	32	system	system	NN
cord-017954-vobslprh	218	33	is	be	VBZ
cord-017954-vobslprh	218	34	not	not	RB
cord-017954-vobslprh	218	35	required	require	VBN
cord-017954-vobslprh	218	36	,	,	,
cord-017954-vobslprh	218	37	as	as	IN
cord-017954-vobslprh	218	38	is	be	VBZ
cord-017954-vobslprh	218	39	seen	see	VBN
cord-017954-vobslprh	218	40	following	follow	VBG
cord-017954-vobslprh	218	41	active	active	JJ
cord-017954-vobslprh	218	42	immunization	immunization	NN
cord-017954-vobslprh	218	43	protocols	protocol	NNS
cord-017954-vobslprh	218	44	.	.	.
cord-017954-vobslprh	219	1	Although	although	IN
cord-017954-vobslprh	219	2	most	most	JJS
cord-017954-vobslprh	219	3	MG	MG	NNP
cord-017954-vobslprh	219	4	patients	patient	NNS
cord-017954-vobslprh	219	5	develop	develop	VBP
cord-017954-vobslprh	219	6	autoreactive	autoreactive	JJ
cord-017954-vobslprh	219	7	antibodies	antibody	NNS
cord-017954-vobslprh	219	8	to	to	IN
cord-017954-vobslprh	219	9	AChR	AChR	NNP
cord-017954-vobslprh	219	10	,	,	,
cord-017954-vobslprh	219	11	approximately	approximately	RB
cord-017954-vobslprh	219	12	20	20	CD
cord-017954-vobslprh	219	13	%	%	NN
cord-017954-vobslprh	219	14	of	of	IN
cord-017954-vobslprh	219	15	MG	MG	NNP
cord-017954-vobslprh	219	16	patients	patient	NNS
cord-017954-vobslprh	219	17	are	be	VBP
cord-017954-vobslprh	219	18	AChR	achr	JJ
cord-017954-vobslprh	219	19	antibody	antibody	NN
cord-017954-vobslprh	219	20	negative	negative	JJ
cord-017954-vobslprh	219	21	;	;	:
cord-017954-vobslprh	219	22	however	however	RB
cord-017954-vobslprh	219	23	,	,	,
cord-017954-vobslprh	219	24	30	30	CD
cord-017954-vobslprh	219	25	-	-	SYM
cord-017954-vobslprh	219	26	40	40	CD
cord-017954-vobslprh	219	27	%	%	NN
cord-017954-vobslprh	219	28	of	of	IN
cord-017954-vobslprh	219	29	these	these	DT
cord-017954-vobslprh	219	30	MG	MG	NNP
cord-017954-vobslprh	219	31	patients	patient	NNS
cord-017954-vobslprh	219	32	have	have	VBP
cord-017954-vobslprh	219	33	antibodies	antibody	NNS
cord-017954-vobslprh	219	34	that	that	WDT
cord-017954-vobslprh	219	35	recognize	recognize	VBP
cord-017954-vobslprh	219	36	muscle	muscle	NN
cord-017954-vobslprh	219	37	-	-	HYPH
cord-017954-vobslprh	219	38	specific	specific	JJ
cord-017954-vobslprh	219	39	kinase	kinase	NN
cord-017954-vobslprh	219	40	(	(	-LRB-
cord-017954-vobslprh	219	41	MuSK	MuSK	NNP
cord-017954-vobslprh	219	42	)	)	-RRB-
cord-017954-vobslprh	219	43	[	[	-LRB-
cord-017954-vobslprh	219	44	108	108	CD
cord-017954-vobslprh	219	45	]	]	-RRB-
cord-017954-vobslprh	219	46	.	.	.
cord-017954-vobslprh	220	1	MuSK	MuSK	NNP
cord-017954-vobslprh	220	2	is	be	VBZ
cord-017954-vobslprh	220	3	a	a	DT
cord-017954-vobslprh	220	4	tyrosine	tyrosine	NN
cord-017954-vobslprh	220	5	kinase	kinase	NN
cord-017954-vobslprh	220	6	receptor	receptor	NN
cord-017954-vobslprh	220	7	that	that	WDT
cord-017954-vobslprh	220	8	is	be	VBZ
cord-017954-vobslprh	220	9	involved	involve	VBN
cord-017954-vobslprh	220	10	in	in	IN
cord-017954-vobslprh	220	11	the	the	DT
cord-017954-vobslprh	220	12	development	development	NN
cord-017954-vobslprh	220	13	of	of	IN
cord-017954-vobslprh	220	14	postsynaptic	postsynaptic	JJ
cord-017954-vobslprh	220	15	membranes	membrane	NNS
cord-017954-vobslprh	220	16	in	in	IN
cord-017954-vobslprh	220	17	the	the	DT
cord-017954-vobslprh	220	18	NMJ	NMJ	NNP
cord-017954-vobslprh	220	19	.	.	.
cord-017954-vobslprh	221	1	However	however	RB
cord-017954-vobslprh	221	2	,	,	,
cord-017954-vobslprh	221	3	whether	whether	IN
cord-017954-vobslprh	221	4	MuSK	MuSK	NNP
cord-017954-vobslprh	221	5	antibodies	antibody	NNS
cord-017954-vobslprh	221	6	are	be	VBP
cord-017954-vobslprh	221	7	involved	involve	VBN
cord-017954-vobslprh	221	8	in	in	IN
cord-017954-vobslprh	221	9	the	the	DT
cord-017954-vobslprh	221	10	pathogenicity	pathogenicity	NN
cord-017954-vobslprh	221	11	of	of	IN
cord-017954-vobslprh	221	12	MG	MG	NNP
cord-017954-vobslprh	221	13	is	be	VBZ
cord-017954-vobslprh	221	14	unclear	unclear	JJ
cord-017954-vobslprh	221	15	and	and	CC
cord-017954-vobslprh	221	16	it	-PRON-	PRP
cord-017954-vobslprh	221	17	is	be	VBZ
cord-017954-vobslprh	221	18	unknown	unknown	JJ
cord-017954-vobslprh	221	19	whether	whether	IN
cord-017954-vobslprh	221	20	they	-PRON-	PRP
cord-017954-vobslprh	221	21	contribute	contribute	VBP
cord-017954-vobslprh	221	22	to	to	IN
cord-017954-vobslprh	221	23	muscle	muscle	NN
cord-017954-vobslprh	221	24	weakness	weakness	NN
cord-017954-vobslprh	221	25	.	.	.
cord-017954-vobslprh	222	1	Therefore	therefore	RB
cord-017954-vobslprh	222	2	,	,	,
cord-017954-vobslprh	222	3	the	the	DT
cord-017954-vobslprh	222	4	use	use	NN
cord-017954-vobslprh	222	5	of	of	IN
cord-017954-vobslprh	222	6	animal	animal	NN
cord-017954-vobslprh	222	7	models	model	NNS
cord-017954-vobslprh	222	8	is	be	VBZ
cord-017954-vobslprh	222	9	useful	useful	JJ
cord-017954-vobslprh	222	10	to	to	TO
cord-017954-vobslprh	222	11	help	help	VB
cord-017954-vobslprh	222	12	dissect	dissect	VB
cord-017954-vobslprh	222	13	the	the	DT
cord-017954-vobslprh	222	14	potential	potential	JJ
cord-017954-vobslprh	222	15	pathogenic	pathogenic	JJ
cord-017954-vobslprh	222	16	function	function	NN
cord-017954-vobslprh	222	17	of	of	IN
cord-017954-vobslprh	222	18	MuSK	MuSK	NNP
cord-017954-vobslprh	222	19	antibodies	antibody	NNS
cord-017954-vobslprh	222	20	.	.	.
cord-017954-vobslprh	223	1	A	a	DT
cord-017954-vobslprh	223	2	recent	recent	JJ
cord-017954-vobslprh	223	3	study	study	NN
cord-017954-vobslprh	223	4	demonstrated	demonstrate	VBD
cord-017954-vobslprh	223	5	that	that	IN
cord-017954-vobslprh	223	6	immunization	immunization	NN
cord-017954-vobslprh	223	7	of	of	IN
cord-017954-vobslprh	223	8	rabbits	rabbit	NNS
cord-017954-vobslprh	223	9	or	or	CC
cord-017954-vobslprh	223	10	mice	mouse	NNS
cord-017954-vobslprh	223	11	with	with	IN
cord-017954-vobslprh	223	12	a	a	DT
cord-017954-vobslprh	223	13	MuSK	MuSK	NNP
cord-017954-vobslprh	223	14	ectodomain	ectodomain	NN
cord-017954-vobslprh	223	15	induced	induce	VBN
cord-017954-vobslprh	223	16	muscle	muscle	NN
cord-017954-vobslprh	223	17	weakness	weakness	NN
cord-017954-vobslprh	223	18	as	as	IN
cord-017954-vobslprh	223	19	measured	measure	VBN
cord-017954-vobslprh	223	20	by	by	IN
cord-017954-vobslprh	223	21	electromyographic	electromyographic	JJ
cord-017954-vobslprh	223	22	analysis	analysis	NN
cord-017954-vobslprh	223	23	and	and	CC
cord-017954-vobslprh	223	24	flaccid	flaccid	JJ
cord-017954-vobslprh	223	25	paralysis	paralysis	NN
cord-017954-vobslprh	223	26	,	,	,
cord-017954-vobslprh	223	27	which	which	WDT
cord-017954-vobslprh	223	28	was	be	VBD
cord-017954-vobslprh	223	29	similar	similar	JJ
cord-017954-vobslprh	223	30	to	to	IN
cord-017954-vobslprh	223	31	that	that	DT
cord-017954-vobslprh	223	32	in	in	IN
cord-017954-vobslprh	223	33	human	human	JJ
cord-017954-vobslprh	223	34	MG	MG	NNP
cord-017954-vobslprh	223	35	[	[	-LRB-
cord-017954-vobslprh	223	36	109	109	CD
cord-017954-vobslprh	223	37	,	,	,
cord-017954-vobslprh	223	38	110	110	CD
cord-017954-vobslprh	223	39	]	]	-RRB-
cord-017954-vobslprh	223	40	.	.	.
cord-017954-vobslprh	224	1	However	however	RB
cord-017954-vobslprh	224	2	,	,	,
cord-017954-vobslprh	224	3	the	the	DT
cord-017954-vobslprh	224	4	appearance	appearance	NN
cord-017954-vobslprh	224	5	of	of	IN
cord-017954-vobslprh	224	6	disease	disease	NN
cord-017954-vobslprh	224	7	-	-	HYPH
cord-017954-vobslprh	224	8	related	relate	VBN
cord-017954-vobslprh	224	9	symptoms	symptom	NNS
cord-017954-vobslprh	224	10	is	be	VBZ
cord-017954-vobslprh	224	11	longer	long	JJR
cord-017954-vobslprh	224	12	than	than	IN
cord-017954-vobslprh	224	13	that	that	DT
cord-017954-vobslprh	224	14	for	for	IN
cord-017954-vobslprh	224	15	AChR	achr	JJ
cord-017954-vobslprh	224	16	-	-	HYPH
cord-017954-vobslprh	224	17	active	active	JJ
cord-017954-vobslprh	224	18	and	and	CC
cord-017954-vobslprh	224	19	AChR	achr	JJ
cord-017954-vobslprh	224	20	-	-	HYPH
cord-017954-vobslprh	224	21	passive	passive	JJ
cord-017954-vobslprh	224	22	models	model	NNS
cord-017954-vobslprh	224	23	of	of	IN
cord-017954-vobslprh	224	24	EAMG	EAMG	NNP
cord-017954-vobslprh	224	25	,	,	,
cord-017954-vobslprh	224	26	and	and	CC
cord-017954-vobslprh	224	27	the	the	DT
cord-017954-vobslprh	224	28	passive	passive	JJ
cord-017954-vobslprh	224	29	transfer	transfer	NN
cord-017954-vobslprh	224	30	of	of	IN
cord-017954-vobslprh	224	31	MuSK	MuSK	NNP
cord-017954-vobslprh	224	32	antibodies	antibody	NNS
cord-017954-vobslprh	224	33	is	be	VBZ
cord-017954-vobslprh	224	34	less	less	RBR
cord-017954-vobslprh	224	35	effective	effective	JJ
cord-017954-vobslprh	224	36	than	than	IN
cord-017954-vobslprh	224	37	the	the	DT
cord-017954-vobslprh	224	38	equivalent	equivalent	JJ
cord-017954-vobslprh	224	39	AChR	achr	JJ
cord-017954-vobslprh	224	40	-	-	HYPH
cord-017954-vobslprh	224	41	passive	passive	JJ
cord-017954-vobslprh	224	42	model	model	NN
cord-017954-vobslprh	224	43	.	.	.
cord-017954-vobslprh	225	1	Therefore	therefore	RB
cord-017954-vobslprh	225	2	,	,	,
cord-017954-vobslprh	225	3	MuSK	MuSK	NNP
cord-017954-vobslprh	225	4	antibody	antibody	NN
cord-017954-vobslprh	225	5	-	-	HYPH
cord-017954-vobslprh	225	6	related	relate	VBN
cord-017954-vobslprh	225	7	MG	MG	NNP
cord-017954-vobslprh	225	8	might	may	MD
cord-017954-vobslprh	225	9	represent	represent	VB
cord-017954-vobslprh	225	10	a	a	DT
cord-017954-vobslprh	225	11	subtype	subtype	NN
cord-017954-vobslprh	225	12	of	of	IN
cord-017954-vobslprh	225	13	MG	MG	NNP
cord-017954-vobslprh	225	14	or	or	CC
cord-017954-vobslprh	225	15	reflect	reflect	VBP
cord-017954-vobslprh	225	16	differences	difference	NNS
cord-017954-vobslprh	225	17	in	in	IN
cord-017954-vobslprh	225	18	environmental	environmental	JJ
cord-017954-vobslprh	225	19	or	or	CC
cord-017954-vobslprh	225	20	genetic	genetic	JJ
cord-017954-vobslprh	225	21	susceptibility	susceptibility	NN
cord-017954-vobslprh	225	22	factors	factor	NNS
cord-017954-vobslprh	225	23	.	.	.
cord-017954-vobslprh	226	1	EAMG	EAMG	NNP
cord-017954-vobslprh	226	2	is	be	VBZ
cord-017954-vobslprh	226	3	a	a	DT
cord-017954-vobslprh	226	4	very	very	RB
cord-017954-vobslprh	226	5	useful	useful	JJ
cord-017954-vobslprh	226	6	animal	animal	NN
cord-017954-vobslprh	226	7	model	model	NN
cord-017954-vobslprh	226	8	for	for	IN
cord-017954-vobslprh	226	9	the	the	DT
cord-017954-vobslprh	226	10	study	study	NN
cord-017954-vobslprh	226	11	of	of	IN
cord-017954-vobslprh	226	12	the	the	DT
cord-017954-vobslprh	226	13	pathways	pathway	NNS
cord-017954-vobslprh	226	14	involved	involve	VBN
cord-017954-vobslprh	226	15	in	in	IN
cord-017954-vobslprh	226	16	disease	disease	NN
cord-017954-vobslprh	226	17	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	226	18	as	as	RB
cord-017954-vobslprh	226	19	well	well	RB
cord-017954-vobslprh	226	20	as	as	IN
cord-017954-vobslprh	226	21	investigating	investigate	VBG
cord-017954-vobslprh	226	22	novel	novel	JJ
cord-017954-vobslprh	226	23	therapeutic	therapeutic	JJ
cord-017954-vobslprh	226	24	strategies	strategy	NNS
cord-017954-vobslprh	226	25	.	.	.
cord-017954-vobslprh	227	1	Importantly	importantly	RB
cord-017954-vobslprh	227	2	,	,	,
cord-017954-vobslprh	227	3	EAMG	EAMG	NNP
cord-017954-vobslprh	227	4	shares	share	VBZ
cord-017954-vobslprh	227	5	similar	similar	JJ
cord-017954-vobslprh	227	6	symptoms	symptom	NNS
cord-017954-vobslprh	227	7	with	with	IN
cord-017954-vobslprh	227	8	MG	MG	NNP
cord-017954-vobslprh	227	9	,	,	,
cord-017954-vobslprh	227	10	especially	especially	RB
cord-017954-vobslprh	227	11	muscle	muscle	NN
cord-017954-vobslprh	227	12	weakness	weakness	NN
cord-017954-vobslprh	227	13	and	and	CC
cord-017954-vobslprh	227	14	fatigue	fatigue	NN
cord-017954-vobslprh	227	15	.	.	.
cord-017954-vobslprh	228	1	Furthermore	furthermore	RB
cord-017954-vobslprh	228	2	,	,	,
cord-017954-vobslprh	228	3	they	-PRON-	PRP
cord-017954-vobslprh	228	4	share	share	VBP
cord-017954-vobslprh	228	5	such	such	JJ
cord-017954-vobslprh	228	6	immunopathological	immunopathological	JJ
cord-017954-vobslprh	228	7	features	feature	NNS
cord-017954-vobslprh	228	8	as	as	IN
cord-017954-vobslprh	228	9	AChRspecific	AChRspecific	NNP
cord-017954-vobslprh	228	10	antibodies	antibody	NNS
cord-017954-vobslprh	228	11	in	in	IN
cord-017954-vobslprh	228	12	the	the	DT
cord-017954-vobslprh	228	13	serum	serum	NN
cord-017954-vobslprh	228	14	,	,	,
cord-017954-vobslprh	228	15	muscle	muscle	NN
cord-017954-vobslprh	228	16	AChR	achr	JJ
cord-017954-vobslprh	228	17	loss	loss	NN
cord-017954-vobslprh	228	18	,	,	,
cord-017954-vobslprh	228	19	presence	presence	NN
cord-017954-vobslprh	228	20	of	of	IN
cord-017954-vobslprh	228	21	complement	complement	NN
cord-017954-vobslprh	228	22	factors	factor	NNS
cord-017954-vobslprh	228	23	such	such	JJ
cord-017954-vobslprh	228	24	as	as	IN
cord-017954-vobslprh	228	25	C3	C3	NNP
cord-017954-vobslprh	228	26	and	and	CC
cord-017954-vobslprh	228	27	C9	C9	NNP
cord-017954-vobslprh	228	28	at	at	IN
cord-017954-vobslprh	228	29	NMJs	nmj	NNS
cord-017954-vobslprh	228	30	,	,	,
cord-017954-vobslprh	228	31	and	and	CC
cord-017954-vobslprh	228	32	a	a	DT
cord-017954-vobslprh	228	33	supportive	supportive	JJ
cord-017954-vobslprh	228	34	role	role	NN
cord-017954-vobslprh	228	35	for	for	IN
cord-017954-vobslprh	228	36	T	T	NNP
cord-017954-vobslprh	228	37	and	and	CC
cord-017954-vobslprh	228	38	B	b	NN
cord-017954-vobslprh	228	39	cells	cell	NNS
cord-017954-vobslprh	228	40	as	as	IN
cord-017954-vobslprh	228	41	regards	regard	VBZ
cord-017954-vobslprh	228	42	autoantibody	autoantibody	NN
cord-017954-vobslprh	228	43	production	production	NN
cord-017954-vobslprh	228	44	.	.	.
cord-017954-vobslprh	229	1	One	one	CD
cord-017954-vobslprh	229	2	of	of	IN
cord-017954-vobslprh	229	3	the	the	DT
cord-017954-vobslprh	229	4	major	major	JJ
cord-017954-vobslprh	229	5	differences	difference	NNS
cord-017954-vobslprh	229	6	between	between	IN
cord-017954-vobslprh	229	7	EAMG	EAMG	NNP
cord-017954-vobslprh	229	8	and	and	CC
cord-017954-vobslprh	229	9	MG	MG	NNP
cord-017954-vobslprh	229	10	is	be	VBZ
cord-017954-vobslprh	229	11	the	the	DT
cord-017954-vobslprh	229	12	involvement	involvement	NN
cord-017954-vobslprh	229	13	of	of	IN
cord-017954-vobslprh	229	14	the	the	DT
cord-017954-vobslprh	229	15	thymus	thymus	NN
cord-017954-vobslprh	229	16	(	(	-LRB-
cord-017954-vobslprh	229	17	loss	loss	NN
cord-017954-vobslprh	229	18	of	of	IN
cord-017954-vobslprh	229	19	self	self	NN
cord-017954-vobslprh	229	20	-	-	HYPH
cord-017954-vobslprh	229	21	tolerance	tolerance	NN
cord-017954-vobslprh	229	22	)	)	-RRB-
cord-017954-vobslprh	229	23	in	in	IN
cord-017954-vobslprh	229	24	human	human	JJ
cord-017954-vobslprh	229	25	MG	MG	NNP
cord-017954-vobslprh	229	26	,	,	,
cord-017954-vobslprh	229	27	which	which	WDT
cord-017954-vobslprh	229	28	is	be	VBZ
cord-017954-vobslprh	229	29	absent	absent	JJ
cord-017954-vobslprh	229	30	in	in	IN
cord-017954-vobslprh	229	31	EAMG	EAMG	NNP
cord-017954-vobslprh	229	32	,	,	,
cord-017954-vobslprh	229	33	where	where	WRB
cord-017954-vobslprh	229	34	tolerance	tolerance	NN
cord-017954-vobslprh	229	35	must	must	MD
cord-017954-vobslprh	229	36	be	be	VB
cord-017954-vobslprh	229	37	"	"	``
cord-017954-vobslprh	229	38	broken	break	VBN
cord-017954-vobslprh	229	39	"	"	''
cord-017954-vobslprh	229	40	by	by	IN
cord-017954-vobslprh	229	41	immunization	immunization	NN
cord-017954-vobslprh	229	42	of	of	IN
cord-017954-vobslprh	229	43	the	the	DT
cord-017954-vobslprh	229	44	autoantigen	autoantigen	NN
cord-017954-vobslprh	229	45	in	in	IN
cord-017954-vobslprh	229	46	complete	complete	JJ
cord-017954-vobslprh	229	47	Freund	Freund	NNP
cord-017954-vobslprh	229	48	's	's	POS
cord-017954-vobslprh	229	49	adjuvant	adjuvant	NN
cord-017954-vobslprh	229	50	.	.	.
cord-017954-vobslprh	230	1	Although	although	IN
cord-017954-vobslprh	230	2	many	many	JJ
cord-017954-vobslprh	230	3	therapeutic	therapeutic	JJ
cord-017954-vobslprh	230	4	strategies	strategy	NNS
cord-017954-vobslprh	230	5	have	have	VBP
cord-017954-vobslprh	230	6	been	be	VBN
cord-017954-vobslprh	230	7	demonstrated	demonstrate	VBN
cord-017954-vobslprh	230	8	to	to	TO
cord-017954-vobslprh	230	9	be	be	VB
cord-017954-vobslprh	230	10	beneficial	beneficial	JJ
cord-017954-vobslprh	230	11	in	in	IN
cord-017954-vobslprh	230	12	EAMG	EAMG	NNP
cord-017954-vobslprh	230	13	,	,	,
cord-017954-vobslprh	230	14	few	few	JJ
cord-017954-vobslprh	230	15	have	have	VBP
cord-017954-vobslprh	230	16	translated	translate	VBN
cord-017954-vobslprh	230	17	to	to	IN
cord-017954-vobslprh	230	18	the	the	DT
cord-017954-vobslprh	230	19	clinic	clinic	NN
cord-017954-vobslprh	230	20	for	for	IN
cord-017954-vobslprh	230	21	human	human	JJ
cord-017954-vobslprh	230	22	MG	MG	NNP
cord-017954-vobslprh	230	23	.	.	.
cord-017954-vobslprh	231	1	This	this	DT
cord-017954-vobslprh	231	2	might	may	MD
cord-017954-vobslprh	231	3	be	be	VB
cord-017954-vobslprh	231	4	due	due	JJ
cord-017954-vobslprh	231	5	to	to	IN
cord-017954-vobslprh	231	6	the	the	DT
cord-017954-vobslprh	231	7	human	human	JJ
cord-017954-vobslprh	231	8	form	form	NN
cord-017954-vobslprh	231	9	of	of	IN
cord-017954-vobslprh	231	10	disease	disease	NN
cord-017954-vobslprh	231	11	having	have	VBG
cord-017954-vobslprh	231	12	a	a	DT
cord-017954-vobslprh	231	13	more	more	RBR
cord-017954-vobslprh	231	14	complex	complex	JJ
cord-017954-vobslprh	231	15	aetiology	aetiology	NN
cord-017954-vobslprh	231	16	than	than	IN
cord-017954-vobslprh	231	17	EAMG	EAMG	NNP
cord-017954-vobslprh	231	18	.	.	.
cord-017954-vobslprh	232	1	However	however	RB
cord-017954-vobslprh	232	2	,	,	,
cord-017954-vobslprh	232	3	EAMG	EAMG	NNP
cord-017954-vobslprh	232	4	still	still	RB
cord-017954-vobslprh	232	5	has	have	VBZ
cord-017954-vobslprh	232	6	an	an	DT
cord-017954-vobslprh	232	7	important	important	JJ
cord-017954-vobslprh	232	8	role	role	NN
cord-017954-vobslprh	232	9	to	to	TO
cord-017954-vobslprh	232	10	play	play	VB
cord-017954-vobslprh	232	11	in	in	IN
cord-017954-vobslprh	232	12	preclinical	preclinical	JJ
cord-017954-vobslprh	232	13	studies	study	NNS
cord-017954-vobslprh	232	14	,	,	,
cord-017954-vobslprh	232	15	whether	whether	IN
cord-017954-vobslprh	232	16	to	to	TO
cord-017954-vobslprh	232	17	investigate	investigate	VB
cord-017954-vobslprh	232	18	pathogenic	pathogenic	JJ
cord-017954-vobslprh	232	19	mechanisms	mechanism	NNS
cord-017954-vobslprh	232	20	or	or	CC
cord-017954-vobslprh	232	21	potential	potential	JJ
cord-017954-vobslprh	232	22	therapeutic	therapeutic	JJ
cord-017954-vobslprh	232	23	strategies	strategy	NNS
cord-017954-vobslprh	232	24	.	.	.
cord-017954-vobslprh	233	1	Despite	despite	IN
cord-017954-vobslprh	233	2	the	the	DT
cord-017954-vobslprh	233	3	numerous	numerous	JJ
cord-017954-vobslprh	233	4	beneficial	beneficial	JJ
cord-017954-vobslprh	233	5	advances	advance	NNS
cord-017954-vobslprh	233	6	of	of	IN
cord-017954-vobslprh	233	7	researchers	researcher	NNS
cord-017954-vobslprh	233	8	in	in	IN
cord-017954-vobslprh	233	9	each	each	DT
cord-017954-vobslprh	233	10	of	of	IN
cord-017954-vobslprh	233	11	these	these	DT
cord-017954-vobslprh	233	12	human	human	JJ
cord-017954-vobslprh	233	13	neuroimmune	neuroimmune	JJ
cord-017954-vobslprh	233	14	diseases	disease	NNS
cord-017954-vobslprh	233	15	,	,	,
cord-017954-vobslprh	233	16	the	the	DT
cord-017954-vobslprh	233	17	underlying	underlie	VBG
cord-017954-vobslprh	233	18	mechanisms	mechanism	NNS
cord-017954-vobslprh	233	19	of	of	IN
cord-017954-vobslprh	233	20	many	many	JJ
cord-017954-vobslprh	233	21	of	of	IN
cord-017954-vobslprh	233	22	these	these	DT
cord-017954-vobslprh	233	23	disease	disease	NN
cord-017954-vobslprh	233	24	processes	process	NNS
cord-017954-vobslprh	233	25	are	be	VBP
cord-017954-vobslprh	233	26	still	still	RB
cord-017954-vobslprh	233	27	unclear	unclear	JJ
cord-017954-vobslprh	233	28	and	and	CC
cord-017954-vobslprh	233	29	this	this	DT
cord-017954-vobslprh	233	30	has	have	VBZ
cord-017954-vobslprh	233	31	hindered	hinder	VBN
cord-017954-vobslprh	233	32	the	the	DT
cord-017954-vobslprh	233	33	search	search	NN
cord-017954-vobslprh	233	34	for	for	IN
cord-017954-vobslprh	233	35	curative	curative	JJ
cord-017954-vobslprh	233	36	therapies	therapy	NNS
cord-017954-vobslprh	233	37	.	.	.
cord-017954-vobslprh	234	1	Although	although	IN
cord-017954-vobslprh	234	2	the	the	DT
cord-017954-vobslprh	234	3	use	use	NN
cord-017954-vobslprh	234	4	of	of	IN
cord-017954-vobslprh	234	5	human	human	JJ
cord-017954-vobslprh	234	6	tissues	tissue	NNS
cord-017954-vobslprh	234	7	and	and	CC
cord-017954-vobslprh	234	8	samples	sample	NNS
cord-017954-vobslprh	234	9	is	be	VBZ
cord-017954-vobslprh	234	10	critical	critical	JJ
cord-017954-vobslprh	234	11	for	for	IN
cord-017954-vobslprh	234	12	these	these	DT
cord-017954-vobslprh	234	13	types	type	NNS
cord-017954-vobslprh	234	14	of	of	IN
cord-017954-vobslprh	234	15	studies	study	NNS
cord-017954-vobslprh	234	16	,	,	,
cord-017954-vobslprh	234	17	often	often	RB
cord-017954-vobslprh	234	18	they	-PRON-	PRP
cord-017954-vobslprh	234	19	are	be	VBP
cord-017954-vobslprh	234	20	invasive	invasive	JJ
cord-017954-vobslprh	234	21	and	and	CC
cord-017954-vobslprh	234	22	provide	provide	VB
cord-017954-vobslprh	234	23	an	an	DT
cord-017954-vobslprh	234	24	indication	indication	NN
cord-017954-vobslprh	234	25	of	of	IN
cord-017954-vobslprh	234	26	a	a	DT
cord-017954-vobslprh	234	27	single	single	JJ
cord-017954-vobslprh	234	28	time	time	NN
cord-017954-vobslprh	234	29	point	point	NN
cord-017954-vobslprh	234	30	within	within	IN
cord-017954-vobslprh	234	31	a	a	DT
cord-017954-vobslprh	234	32	disease	disease	NN
cord-017954-vobslprh	234	33	process	process	NN
cord-017954-vobslprh	234	34	that	that	WDT
cord-017954-vobslprh	234	35	might	may	MD
cord-017954-vobslprh	234	36	have	have	VB
cord-017954-vobslprh	234	37	been	be	VBN
cord-017954-vobslprh	234	38	ongoing	ongoing	JJ
cord-017954-vobslprh	234	39	for	for	IN
cord-017954-vobslprh	234	40	years	year	NNS
cord-017954-vobslprh	234	41	or	or	CC
cord-017954-vobslprh	234	42	decades	decade	NNS
cord-017954-vobslprh	234	43	.	.	.
cord-017954-vobslprh	235	1	Therefore	therefore	RB
cord-017954-vobslprh	235	2	,	,	,
cord-017954-vobslprh	235	3	it	-PRON-	PRP
cord-017954-vobslprh	235	4	is	be	VBZ
cord-017954-vobslprh	235	5	vital	vital	JJ
cord-017954-vobslprh	235	6	to	to	TO
cord-017954-vobslprh	235	7	use	use	VB
cord-017954-vobslprh	235	8	animal	animal	NN
cord-017954-vobslprh	235	9	models	model	NNS
cord-017954-vobslprh	235	10	to	to	TO
cord-017954-vobslprh	235	11	fill	fill	VB
cord-017954-vobslprh	235	12	in	in	RP
cord-017954-vobslprh	235	13	the	the	DT
cord-017954-vobslprh	235	14	"	"	``
cord-017954-vobslprh	235	15	gaps	gap	NNS
cord-017954-vobslprh	235	16	"	"	''
cord-017954-vobslprh	235	17	that	that	WDT
cord-017954-vobslprh	235	18	can	can	MD
cord-017954-vobslprh	235	19	not	not	RB
cord-017954-vobslprh	235	20	be	be	VB
cord-017954-vobslprh	235	21	analysed	analyse	VBN
cord-017954-vobslprh	235	22	by	by	IN
cord-017954-vobslprh	235	23	research	research	NN
cord-017954-vobslprh	235	24	using	use	VBG
cord-017954-vobslprh	235	25	human	human	JJ
cord-017954-vobslprh	235	26	tissues	tissue	NNS
cord-017954-vobslprh	235	27	.	.	.
cord-017954-vobslprh	236	1	However	however	RB
cord-017954-vobslprh	236	2	,	,	,
cord-017954-vobslprh	236	3	whilst	whilst	IN
cord-017954-vobslprh	236	4	animal	animal	NN
cord-017954-vobslprh	236	5	models	model	NNS
cord-017954-vobslprh	236	6	of	of	IN
cord-017954-vobslprh	236	7	disease	disease	NN
cord-017954-vobslprh	236	8	can	can	MD
cord-017954-vobslprh	236	9	provide	provide	VB
cord-017954-vobslprh	236	10	useful	useful	JJ
cord-017954-vobslprh	236	11	information	information	NN
cord-017954-vobslprh	236	12	,	,	,
cord-017954-vobslprh	236	13	it	-PRON-	PRP
cord-017954-vobslprh	236	14	is	be	VBZ
cord-017954-vobslprh	236	15	important	important	JJ
cord-017954-vobslprh	236	16	to	to	TO
cord-017954-vobslprh	236	17	note	note	VB
cord-017954-vobslprh	236	18	that	that	IN
cord-017954-vobslprh	236	19	no	no	DT
cord-017954-vobslprh	236	20	single	single	JJ
cord-017954-vobslprh	236	21	model	model	NN
cord-017954-vobslprh	236	22	is	be	VBZ
cord-017954-vobslprh	236	23	a	a	DT
cord-017954-vobslprh	236	24	perfect	perfect	JJ
cord-017954-vobslprh	236	25	model	model	NN
cord-017954-vobslprh	236	26	of	of	IN
cord-017954-vobslprh	236	27	its	-PRON-	PRP$
cord-017954-vobslprh	236	28	human	human	JJ
cord-017954-vobslprh	236	29	counterpart	counterpart	NN
cord-017954-vobslprh	236	30	and	and	CC
cord-017954-vobslprh	236	31	each	each	DT
cord-017954-vobslprh	236	32	has	have	VBZ
cord-017954-vobslprh	236	33	their	-PRON-	PRP$
cord-017954-vobslprh	236	34	advantages	advantage	NNS
cord-017954-vobslprh	236	35	and	and	CC
cord-017954-vobslprh	236	36	disadvantages	disadvantage	NNS
cord-017954-vobslprh	236	37	.	.	.
cord-017954-vobslprh	237	1	Therefore	therefore	RB
cord-017954-vobslprh	237	2	,	,	,
cord-017954-vobslprh	237	3	it	-PRON-	PRP
cord-017954-vobslprh	237	4	is	be	VBZ
cord-017954-vobslprh	237	5	important	important	JJ
cord-017954-vobslprh	237	6	to	to	TO
cord-017954-vobslprh	237	7	use	use	VB
cord-017954-vobslprh	237	8	the	the	DT
cord-017954-vobslprh	237	9	correct	correct	JJ
cord-017954-vobslprh	237	10	model	model	NN
cord-017954-vobslprh	237	11	for	for	IN
cord-017954-vobslprh	237	12	the	the	DT
cord-017954-vobslprh	237	13	study	study	NN
cord-017954-vobslprh	237	14	involved	involve	VBN
cord-017954-vobslprh	237	15	,	,	,
cord-017954-vobslprh	237	16	i.e.	i.e.	FW
cord-017954-vobslprh	237	17	immune	immune	JJ
cord-017954-vobslprh	237	18	cell	cell	NN
cord-017954-vobslprh	237	19	activation	activation	NN
cord-017954-vobslprh	237	20	,	,	,
cord-017954-vobslprh	237	21	mechanisms	mechanism	NNS
cord-017954-vobslprh	237	22	of	of	IN
cord-017954-vobslprh	237	23	demyelination	demyelination	NN
cord-017954-vobslprh	237	24	,	,	,
cord-017954-vobslprh	237	25	immune	immune	JJ
cord-017954-vobslprh	237	26	cell	cell	NN
cord-017954-vobslprh	237	27	trafficking	traffic	VBG
cord-017954-vobslprh	237	28	into	into	IN
cord-017954-vobslprh	237	29	the	the	DT
cord-017954-vobslprh	237	30	target	target	NN
cord-017954-vobslprh	237	31	organ	organ	NN
cord-017954-vobslprh	237	32	,	,	,
cord-017954-vobslprh	237	33	induction	induction	NN
cord-017954-vobslprh	237	34	vs	vs	IN
cord-017954-vobslprh	237	35	effector	effector	NN
cord-017954-vobslprh	237	36	phases	phase	NNS
cord-017954-vobslprh	237	37	of	of	IN
cord-017954-vobslprh	237	38	disease	disease	NN
cord-017954-vobslprh	237	39	or	or	CC
cord-017954-vobslprh	237	40	routine	routine	JJ
cord-017954-vobslprh	237	41	drug	drug	NN
cord-017954-vobslprh	237	42	testing	testing	NN
cord-017954-vobslprh	237	43	.	.	.
cord-017954-vobslprh	238	1	In	in	IN
cord-017954-vobslprh	238	2	addition	addition	NN
cord-017954-vobslprh	238	3	,	,	,
cord-017954-vobslprh	238	4	it	-PRON-	PRP
cord-017954-vobslprh	238	5	is	be	VBZ
cord-017954-vobslprh	238	6	important	important	JJ
cord-017954-vobslprh	238	7	to	to	TO
cord-017954-vobslprh	238	8	remember	remember	VB
cord-017954-vobslprh	238	9	that	that	IN
cord-017954-vobslprh	238	10	each	each	DT
cord-017954-vobslprh	238	11	mouse	mouse	NN
cord-017954-vobslprh	238	12	strain	strain	NN
cord-017954-vobslprh	238	13	used	use	VBN
cord-017954-vobslprh	238	14	is	be	VBZ
cord-017954-vobslprh	238	15	genetically	genetically	RB
cord-017954-vobslprh	238	16	representative	representative	NN
cord-017954-vobslprh	238	17	of	of	IN
cord-017954-vobslprh	238	18	a	a	DT
cord-017954-vobslprh	238	19	single	single	JJ
cord-017954-vobslprh	238	20	human	human	JJ
cord-017954-vobslprh	238	21	individual	individual	NN
cord-017954-vobslprh	238	22	;	;	:
cord-017954-vobslprh	238	23	therefore	therefore	RB
cord-017954-vobslprh	238	24	,	,	,
cord-017954-vobslprh	238	25	multiple	multiple	JJ
cord-017954-vobslprh	238	26	strains	strain	NNS
cord-017954-vobslprh	238	27	should	should	MD
cord-017954-vobslprh	238	28	ideally	ideally	RB
cord-017954-vobslprh	238	29	be	be	VB
cord-017954-vobslprh	238	30	used	use	VBN
cord-017954-vobslprh	238	31	when	when	WRB
cord-017954-vobslprh	238	32	developing	develop	VBG
cord-017954-vobslprh	238	33	novel	novel	JJ
cord-017954-vobslprh	238	34	treatments	treatment	NNS
cord-017954-vobslprh	238	35	or	or	CC
cord-017954-vobslprh	238	36	investigating	investigate	VBG
cord-017954-vobslprh	238	37	pathogenic	pathogenic	JJ
cord-017954-vobslprh	238	38	mechanisms	mechanism	NNS
cord-017954-vobslprh	238	39	,	,	,
cord-017954-vobslprh	238	40	to	to	TO
cord-017954-vobslprh	238	41	reduce	reduce	VB
cord-017954-vobslprh	238	42	the	the	DT
cord-017954-vobslprh	238	43	possibility	possibility	NN
cord-017954-vobslprh	238	44	of	of	IN
cord-017954-vobslprh	238	45	strain	strain	NN
cord-017954-vobslprh	238	46	irregularities	irregularity	NNS
cord-017954-vobslprh	238	47	confounding	confound	VBG
cord-017954-vobslprh	238	48	the	the	DT
cord-017954-vobslprh	238	49	results	result	NNS
cord-017954-vobslprh	238	50	.	.	.
cord-017954-vobslprh	239	1	Incidence	incidence	NN
cord-017954-vobslprh	239	2	and	and	CC
cord-017954-vobslprh	239	3	significance	significance	NN
cord-017954-vobslprh	239	4	of	of	IN
cord-017954-vobslprh	239	5	neutralizing	neutralize	VBG
cord-017954-vobslprh	239	6	antibodies	antibody	NNS
cord-017954-vobslprh	239	7	to	to	TO
cord-017954-vobslprh	239	8	interferon	interferon	NNP
cord-017954-vobslprh	239	9	beta-1a	beta-1a	NNP
cord-017954-vobslprh	239	10	in	in	IN
cord-017954-vobslprh	239	11	multiple	multiple	JJ
cord-017954-vobslprh	239	12	sclerosis	sclerosis	NN
cord-017954-vobslprh	239	13	.	.	.
cord-017954-vobslprh	240	1	Multiple	Multiple	NNP
cord-017954-vobslprh	240	2	Sclerosis	Sclerosis	NNP
cord-017954-vobslprh	240	3	Collaborative	Collaborative	NNP
cord-017954-vobslprh	240	4	Research	Research	NNP
cord-017954-vobslprh	240	5	Group	Group	NNP
cord-017954-vobslprh	240	6	(	(	-LRB-
cord-017954-vobslprh	240	7	MSCRG	MSCRG	NNP
cord-017954-vobslprh	240	8	)	)	-RRB-
cord-017954-vobslprh	241	1	Progressive	progressive	JJ
cord-017954-vobslprh	241	2	multifocal	multifocal	JJ
cord-017954-vobslprh	241	3	leukoencephalopathy	leukoencephalopathy	NNP
cord-017954-vobslprh	241	4	complicating	complicate	VBG
cord-017954-vobslprh	241	5	treatment	treatment	NN
cord-017954-vobslprh	241	6	with	with	IN
cord-017954-vobslprh	241	7	natalizumab	natalizumab	NNS
cord-017954-vobslprh	241	8	and	and	CC
cord-017954-vobslprh	241	9	interferon	interferon	NNP
cord-017954-vobslprh	241	10	beta-1a	beta-1a	NNP
cord-017954-vobslprh	241	11	for	for	IN
cord-017954-vobslprh	241	12	multiple	multiple	JJ
cord-017954-vobslprh	241	13	sclerosis	sclerosis	NN
cord-017954-vobslprh	242	1	The	the	DT
cord-017954-vobslprh	242	2	rapid	rapid	JJ
cord-017954-vobslprh	242	3	isolation	isolation	NN
cord-017954-vobslprh	242	4	of	of	IN
cord-017954-vobslprh	242	5	clonable	clonable	JJ
cord-017954-vobslprh	242	6	antigen	antigen	NN
cord-017954-vobslprh	242	7	-	-	HYPH
cord-017954-vobslprh	242	8	specific	specific	JJ
cord-017954-vobslprh	242	9	T	T	NNP
cord-017954-vobslprh	242	10	lymphocyte	lymphocyte	NN
cord-017954-vobslprh	242	11	lines	line	NNS
cord-017954-vobslprh	242	12	capable	capable	JJ
cord-017954-vobslprh	242	13	of	of	IN
cord-017954-vobslprh	242	14	mediating	mediate	VBG
cord-017954-vobslprh	242	15	autoimmune	autoimmune	JJ
cord-017954-vobslprh	242	16	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	242	17	Adoptive	adoptive	JJ
cord-017954-vobslprh	242	18	transfer	transfer	NN
cord-017954-vobslprh	242	19	of	of	IN
cord-017954-vobslprh	242	20	experimental	experimental	JJ
cord-017954-vobslprh	242	21	allergic	allergic	JJ
cord-017954-vobslprh	242	22	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	242	23	in	in	IN
cord-017954-vobslprh	242	24	SJL	SJL	NNP
cord-017954-vobslprh	242	25	/	/	SYM
cord-017954-vobslprh	242	26	J	J	NNP
cord-017954-vobslprh	242	27	mice	mouse	NNS
cord-017954-vobslprh	242	28	after	after	IN
cord-017954-vobslprh	242	29	in	in	IN
cord-017954-vobslprh	242	30	vitro	vitro	FW
cord-017954-vobslprh	242	31	activation	activation	NN
cord-017954-vobslprh	242	32	of	of	IN
cord-017954-vobslprh	242	33	lymph	lymph	NN
cord-017954-vobslprh	242	34	node	node	NN
cord-017954-vobslprh	242	35	cells	cell	NNS
cord-017954-vobslprh	242	36	by	by	IN
cord-017954-vobslprh	242	37	myelin	myelin	JJ
cord-017954-vobslprh	242	38	basic	basic	JJ
cord-017954-vobslprh	242	39	protein	protein	NN
cord-017954-vobslprh	242	40	:	:	:
cord-017954-vobslprh	242	41	requirement	requirement	NN
cord-017954-vobslprh	242	42	for	for	IN
cord-017954-vobslprh	242	43	Lyt	Lyt	NNP
cord-017954-vobslprh	242	44	1þ	1þ	CD
cord-017954-vobslprh	242	45	2-T	2-t	CD
cord-017954-vobslprh	242	46	lymphocytes	lymphocyte	NNS
cord-017954-vobslprh	242	47	Epidemiologic	epidemiologic	JJ
cord-017954-vobslprh	242	48	evidence	evidence	NN
cord-017954-vobslprh	242	49	for	for	IN
cord-017954-vobslprh	242	50	multiple	multiple	JJ
cord-017954-vobslprh	242	51	sclerosis	sclerosis	NN
cord-017954-vobslprh	242	52	as	as	IN
cord-017954-vobslprh	242	53	an	an	DT
cord-017954-vobslprh	242	54	infection	infection	NN
cord-017954-vobslprh	242	55	Multiple	multiple	JJ
cord-017954-vobslprh	242	56	sclerosis	sclerosis	NN
cord-017954-vobslprh	242	57	:	:	:
cord-017954-vobslprh	242	58	distribution	distribution	NN
cord-017954-vobslprh	242	59	of	of	IN
cord-017954-vobslprh	242	60	T	T	NNP
cord-017954-vobslprh	242	61	cell	cell	NN
cord-017954-vobslprh	242	62	subsets	subset	NNS
cord-017954-vobslprh	242	63	within	within	IN
cord-017954-vobslprh	242	64	active	active	JJ
cord-017954-vobslprh	242	65	chronic	chronic	JJ
cord-017954-vobslprh	242	66	lesions	lesion	NNS
cord-017954-vobslprh	242	67	Immunohistochemical	Immunohistochemical	NNP
cord-017954-vobslprh	242	68	analysis	analysis	NN
cord-017954-vobslprh	242	69	of	of	IN
cord-017954-vobslprh	242	70	the	the	DT
cord-017954-vobslprh	242	71	cellular	cellular	JJ
cord-017954-vobslprh	242	72	infiltrate	infiltrate	NN
cord-017954-vobslprh	242	73	in	in	IN
cord-017954-vobslprh	242	74	multiple	multiple	JJ
cord-017954-vobslprh	242	75	sclerosis	sclerosis	NN
cord-017954-vobslprh	242	76	lesions	lesion	NNS
cord-017954-vobslprh	242	77	Epitope	Epitope	NNP
cord-017954-vobslprh	242	78	spreading	spreading	NN
cord-017954-vobslprh	242	79	initiates	initiate	NNS
cord-017954-vobslprh	242	80	in	in	IN
cord-017954-vobslprh	242	81	the	the	DT
cord-017954-vobslprh	242	82	CNS	CNS	NNP
cord-017954-vobslprh	242	83	in	in	IN
cord-017954-vobslprh	242	84	two	two	CD
cord-017954-vobslprh	242	85	mouse	mouse	NN
cord-017954-vobslprh	242	86	models	model	NNS
cord-017954-vobslprh	242	87	of	of	IN
cord-017954-vobslprh	242	88	multiple	multiple	JJ
cord-017954-vobslprh	242	89	sclerosis	sclerosis	NN
cord-017954-vobslprh	242	90	Induction	induction	NN
cord-017954-vobslprh	242	91	of	of	IN
cord-017954-vobslprh	242	92	chronic	chronic	JJ
cord-017954-vobslprh	242	93	relapsing	relapse	VBG
cord-017954-vobslprh	242	94	experimental	experimental	JJ
cord-017954-vobslprh	242	95	allergic	allergic	JJ
cord-017954-vobslprh	242	96	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	242	97	in	in	IN
cord-017954-vobslprh	242	98	Biozzi	Biozzi	NNP
cord-017954-vobslprh	242	99	mice	mouse	NNS
cord-017954-vobslprh	243	1	The	the	DT
cord-017954-vobslprh	243	2	role	role	NN
cord-017954-vobslprh	243	3	of	of	IN
cord-017954-vobslprh	243	4	genetic	genetic	JJ
cord-017954-vobslprh	243	5	factors	factor	NNS
cord-017954-vobslprh	243	6	in	in	IN
cord-017954-vobslprh	243	7	multiple	multiple	JJ
cord-017954-vobslprh	243	8	sclerosis	sclerosis	NN
cord-017954-vobslprh	243	9	susceptibility	susceptibility	NN
cord-017954-vobslprh	243	10	Experimental	experimental	JJ
cord-017954-vobslprh	243	11	autoimmune	autoimmune	JJ
cord-017954-vobslprh	243	12	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	243	13	in	in	IN
cord-017954-vobslprh	243	14	the	the	DT
cord-017954-vobslprh	243	15	mouse	mouse	NN
cord-017954-vobslprh	243	16	Mouse	Mouse	NNP
cord-017954-vobslprh	243	17	models	model	NNS
cord-017954-vobslprh	243	18	of	of	IN
cord-017954-vobslprh	243	19	multiple	multiple	JJ
cord-017954-vobslprh	243	20	sclerosis	sclerosis	NN
cord-017954-vobslprh	243	21	:	:	:
cord-017954-vobslprh	243	22	experimental	experimental	JJ
cord-017954-vobslprh	243	23	autoimmune	autoimmune	JJ
cord-017954-vobslprh	243	24	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	243	25	and	and	CC
cord-017954-vobslprh	243	26	Theiler	Theiler	NNP
cord-017954-vobslprh	243	27	's	's	POS
cord-017954-vobslprh	243	28	virus	virus	NN
cord-017954-vobslprh	243	29	-	-	HYPH
cord-017954-vobslprh	243	30	induced	induce	VBN
cord-017954-vobslprh	243	31	demyelinating	demyelinate	VBG
cord-017954-vobslprh	243	32	disease	disease	NN
cord-017954-vobslprh	243	33	A	a	DT
cord-017954-vobslprh	243	34	genome	genome	NN
cord-017954-vobslprh	243	35	screen	screen	NN
cord-017954-vobslprh	243	36	in	in	IN
cord-017954-vobslprh	243	37	multiple	multiple	JJ
cord-017954-vobslprh	243	38	sclerosis	sclerosis	NN
cord-017954-vobslprh	243	39	reveals	reveal	VBZ
cord-017954-vobslprh	243	40	susceptibility	susceptibility	NN
cord-017954-vobslprh	243	41	loci	locus	NNS
cord-017954-vobslprh	243	42	on	on	IN
cord-017954-vobslprh	243	43	chromosome	chromosome	NN
cord-017954-vobslprh	243	44	6p21	6p21	CD
cord-017954-vobslprh	243	45	and	and	CC
cord-017954-vobslprh	243	46	17q22	17q22	CD
cord-017954-vobslprh	243	47	A	a	DT
cord-017954-vobslprh	243	48	full	full	JJ
cord-017954-vobslprh	243	49	genome	genome	NN
cord-017954-vobslprh	243	50	search	search	NN
cord-017954-vobslprh	243	51	in	in	IN
cord-017954-vobslprh	243	52	multiple	multiple	JJ
cord-017954-vobslprh	243	53	sclerosis	sclerosis	NN
cord-017954-vobslprh	244	1	A	a	DT
cord-017954-vobslprh	244	2	complete	complete	JJ
cord-017954-vobslprh	244	3	genomic	genomic	JJ
cord-017954-vobslprh	244	4	screen	screen	NN
cord-017954-vobslprh	244	5	for	for	IN
cord-017954-vobslprh	244	6	multiple	multiple	JJ
cord-017954-vobslprh	244	7	sclerosis	sclerosis	NN
cord-017954-vobslprh	244	8	underscores	underscore	VBZ
cord-017954-vobslprh	244	9	a	a	DT
cord-017954-vobslprh	244	10	role	role	NN
cord-017954-vobslprh	244	11	for	for	IN
cord-017954-vobslprh	244	12	the	the	DT
cord-017954-vobslprh	244	13	major	major	JJ
cord-017954-vobslprh	244	14	histocompatibility	histocompatibility	NN
cord-017954-vobslprh	244	15	complex	complex	NN
cord-017954-vobslprh	244	16	.	.	.
cord-017954-vobslprh	245	1	The	the	DT
cord-017954-vobslprh	245	2	Multiple	Multiple	NNP
cord-017954-vobslprh	245	3	Sclerosis	Sclerosis	NNP
cord-017954-vobslprh	245	4	Genetics	Genetics	NNP
cord-017954-vobslprh	245	5	Group	Group	NNP
cord-017954-vobslprh	245	6	Encephalitogenic	Encephalitogenic	NNP
cord-017954-vobslprh	245	7	T	T	NNP
cord-017954-vobslprh	245	8	cells	cell	NNS
cord-017954-vobslprh	245	9	in	in	IN
cord-017954-vobslprh	245	10	the	the	DT
cord-017954-vobslprh	245	11	B10.PL	B10.PL	NNP
cord-017954-vobslprh	245	12	model	model	NN
cord-017954-vobslprh	245	13	of	of	IN
cord-017954-vobslprh	245	14	experimental	experimental	JJ
cord-017954-vobslprh	245	15	allergic	allergic	JJ
cord-017954-vobslprh	245	16	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	245	17	(	(	-LRB-
cord-017954-vobslprh	245	18	EAE	EAE	NNP
cord-017954-vobslprh	245	19	)	)	-RRB-
cord-017954-vobslprh	245	20	are	be	VBP
cord-017954-vobslprh	245	21	of	of	IN
cord-017954-vobslprh	245	22	the	the	DT
cord-017954-vobslprh	245	23	Th-1	Th-1	NNP
cord-017954-vobslprh	245	24	lymphokine	lymphokine	NN
cord-017954-vobslprh	245	25	subtype	subtype	NN
cord-017954-vobslprh	245	26	Surface	surface	NN
cord-017954-vobslprh	245	27	expression	expression	NN
cord-017954-vobslprh	245	28	of	of	IN
cord-017954-vobslprh	245	29	alpha	alpha	NN
cord-017954-vobslprh	245	30	4	4	CD
cord-017954-vobslprh	245	31	integrin	integrin	NN
cord-017954-vobslprh	245	32	by	by	IN
cord-017954-vobslprh	245	33	CD4	CD4	NNP
cord-017954-vobslprh	245	34	T	T	NNP
cord-017954-vobslprh	245	35	cells	cell	NNS
cord-017954-vobslprh	245	36	is	be	VBZ
cord-017954-vobslprh	245	37	required	require	VBN
cord-017954-vobslprh	245	38	for	for	IN
cord-017954-vobslprh	245	39	their	-PRON-	PRP$
cord-017954-vobslprh	245	40	entry	entry	NN
cord-017954-vobslprh	245	41	into	into	IN
cord-017954-vobslprh	245	42	brain	brain	NN
cord-017954-vobslprh	245	43	parenchyma	parenchyma	NN
cord-017954-vobslprh	245	44	Lymphotoxin	Lymphotoxin	NNP
cord-017954-vobslprh	245	45	and	and	CC
cord-017954-vobslprh	245	46	tumor	tumor	NN
cord-017954-vobslprh	245	47	necrosis	necrosis	NN
cord-017954-vobslprh	245	48	factor	factor	NN
cord-017954-vobslprh	245	49	-	-	HYPH
cord-017954-vobslprh	245	50	alpha	alpha	NN
cord-017954-vobslprh	245	51	production	production	NN
cord-017954-vobslprh	245	52	by	by	IN
cord-017954-vobslprh	245	53	myelin	myelin	JJ
cord-017954-vobslprh	245	54	basic	basic	JJ
cord-017954-vobslprh	245	55	protein	protein	NN
cord-017954-vobslprh	245	56	-	-	HYPH
cord-017954-vobslprh	245	57	specific	specific	JJ
cord-017954-vobslprh	245	58	T	T	NNP
cord-017954-vobslprh	245	59	cell	cell	NN
cord-017954-vobslprh	245	60	clones	clone	NNS
cord-017954-vobslprh	245	61	correlates	correlate	VBZ
cord-017954-vobslprh	245	62	with	with	IN
cord-017954-vobslprh	245	63	encephalitogenicity	encephalitogenicity	NNP
cord-017954-vobslprh	245	64	Fathman	Fathman	NNP
cord-017954-vobslprh	245	65	CG	CG	NNP
cord-017954-vobslprh	245	66	Mice	Mice	NNP
cord-017954-vobslprh	245	67	with	with	IN
cord-017954-vobslprh	245	68	a	a	DT
cord-017954-vobslprh	245	69	disrupted	disrupt	VBN
cord-017954-vobslprh	245	70	IFN	IFN	NNP
cord-017954-vobslprh	245	71	-	-	HYPH
cord-017954-vobslprh	245	72	gamma	gamma	NN
cord-017954-vobslprh	245	73	gene	gene	NN
cord-017954-vobslprh	245	74	are	be	VBP
cord-017954-vobslprh	245	75	susceptible	susceptible	JJ
cord-017954-vobslprh	245	76	to	to	IN
cord-017954-vobslprh	245	77	the	the	DT
cord-017954-vobslprh	245	78	induction	induction	NN
cord-017954-vobslprh	245	79	of	of	IN
cord-017954-vobslprh	246	1	experimental	experimental	JJ
cord-017954-vobslprh	246	2	autoimmune	autoimmune	JJ
cord-017954-vobslprh	246	3	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	246	4	(	(	-LRB-
cord-017954-vobslprh	246	5	EAE	EAE	NNP
cord-017954-vobslprh	246	6	)	)	-RRB-
cord-017954-vobslprh	246	7	TNF	TNF	NNP
cord-017954-vobslprh	246	8	is	be	VBZ
cord-017954-vobslprh	246	9	a	a	DT
cord-017954-vobslprh	246	10	potent	potent	JJ
cord-017954-vobslprh	246	11	anti	anti	JJ
cord-017954-vobslprh	246	12	-	-	JJ
cord-017954-vobslprh	246	13	inflammatory	inflammatory	JJ
cord-017954-vobslprh	246	14	cytokine	cytokine	NN
cord-017954-vobslprh	246	15	in	in	IN
cord-017954-vobslprh	246	16	autoimmune	autoimmune	NN
cord-017954-vobslprh	246	17	-	-	HYPH
cord-017954-vobslprh	246	18	mediated	mediate	VBN
cord-017954-vobslprh	246	19	demyelination	demyelination	NN
cord-017954-vobslprh	246	20	Gene	gene	NN
cord-017954-vobslprh	246	21	-	-	HYPH
cord-017954-vobslprh	246	22	microarray	microarray	NN
cord-017954-vobslprh	246	23	analysis	analysis	NN
cord-017954-vobslprh	246	24	of	of	IN
cord-017954-vobslprh	246	25	multiple	multiple	JJ
cord-017954-vobslprh	246	26	sclerosis	sclerosis	NN
cord-017954-vobslprh	246	27	lesions	lesion	NNS
cord-017954-vobslprh	246	28	yields	yield	VBZ
cord-017954-vobslprh	246	29	new	new	JJ
cord-017954-vobslprh	246	30	targets	target	NNS
cord-017954-vobslprh	246	31	validated	validate	VBN
cord-017954-vobslprh	246	32	in	in	IN
cord-017954-vobslprh	246	33	autoimmune	autoimmune	JJ
cord-017954-vobslprh	246	34	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	246	35	Human	Human	NNP
cord-017954-vobslprh	246	36	TH17	TH17	NNP
cord-017954-vobslprh	246	37	lymphocytes	lymphocyte	NNS
cord-017954-vobslprh	246	38	promote	promote	VBP
cord-017954-vobslprh	246	39	blood	blood	NN
cord-017954-vobslprh	246	40	-	-	HYPH
cord-017954-vobslprh	246	41	brain	brain	NN
cord-017954-vobslprh	246	42	barrier	barrier	NN
cord-017954-vobslprh	246	43	disruption	disruption	NN
cord-017954-vobslprh	246	44	and	and	CC
cord-017954-vobslprh	246	45	central	central	JJ
cord-017954-vobslprh	246	46	nervous	nervous	JJ
cord-017954-vobslprh	246	47	system	system	NN
cord-017954-vobslprh	247	1	inflammation	inflammation	NN
cord-017954-vobslprh	247	2	IL-17	IL-17	NNP
cord-017954-vobslprh	247	3	plays	play	VBZ
cord-017954-vobslprh	247	4	an	an	DT
cord-017954-vobslprh	247	5	important	important	JJ
cord-017954-vobslprh	247	6	role	role	NN
cord-017954-vobslprh	247	7	in	in	IN
cord-017954-vobslprh	247	8	the	the	DT
cord-017954-vobslprh	247	9	development	development	NN
cord-017954-vobslprh	247	10	of	of	IN
cord-017954-vobslprh	247	11	experimental	experimental	JJ
cord-017954-vobslprh	247	12	autoimmune	autoimmune	JJ
cord-017954-vobslprh	247	13	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	247	14	IL-23	IL-23	NNP
cord-017954-vobslprh	247	15	drives	drive	VBZ
cord-017954-vobslprh	247	16	a	a	DT
cord-017954-vobslprh	247	17	pathogenic	pathogenic	JJ
cord-017954-vobslprh	247	18	T	t	NN
cord-017954-vobslprh	247	19	cell	cell	NN
cord-017954-vobslprh	247	20	population	population	NN
cord-017954-vobslprh	247	21	that	that	WDT
cord-017954-vobslprh	247	22	induces	induce	VBZ
cord-017954-vobslprh	247	23	autoimmune	autoimmune	JJ
cord-017954-vobslprh	247	24	inflammation	inflammation	NN
cord-017954-vobslprh	247	25	Immunohistological	Immunohistological	NNP
cord-017954-vobslprh	247	26	analysis	analysis	NN
cord-017954-vobslprh	247	27	of	of	IN
cord-017954-vobslprh	247	28	T	T	NNP
cord-017954-vobslprh	247	29	lymphocyte	lymphocyte	NN
cord-017954-vobslprh	247	30	subsets	subset	NNS
cord-017954-vobslprh	247	31	in	in	IN
cord-017954-vobslprh	247	32	the	the	DT
cord-017954-vobslprh	247	33	central	central	JJ
cord-017954-vobslprh	247	34	nervous	nervous	JJ
cord-017954-vobslprh	247	35	system	system	NN
cord-017954-vobslprh	247	36	in	in	IN
cord-017954-vobslprh	247	37	chronic	chronic	JJ
cord-017954-vobslprh	247	38	progressive	progressive	JJ
cord-017954-vobslprh	247	39	multiple	multiple	JJ
cord-017954-vobslprh	247	40	sclerosis	sclerosis	NN
cord-017954-vobslprh	248	1	The	the	DT
cord-017954-vobslprh	248	2	immunopathology	immunopathology	NN
cord-017954-vobslprh	248	3	of	of	IN
cord-017954-vobslprh	248	4	multiple	multiple	JJ
cord-017954-vobslprh	248	5	sclerosis	sclerosis	NN
cord-017954-vobslprh	248	6	:	:	:
cord-017954-vobslprh	248	7	an	an	DT
cord-017954-vobslprh	248	8	overview	overview	NN
cord-017954-vobslprh	248	9	A	a	DT
cord-017954-vobslprh	248	10	pathogenic	pathogenic	JJ
cord-017954-vobslprh	248	11	role	role	NN
cord-017954-vobslprh	248	12	for	for	IN
cord-017954-vobslprh	248	13	myelin	myelin	NN
cord-017954-vobslprh	248	14	-	-	HYPH
cord-017954-vobslprh	248	15	specific	specific	JJ
cord-017954-vobslprh	248	16	CD8(þ	cd8(þ	NN
cord-017954-vobslprh	248	17	)	)	-RRB-
cord-017954-vobslprh	249	1	T	T	NNP
cord-017954-vobslprh	249	2	cells	cell	NNS
cord-017954-vobslprh	249	3	in	in	IN
cord-017954-vobslprh	249	4	a	a	DT
cord-017954-vobslprh	249	5	model	model	NN
cord-017954-vobslprh	249	6	for	for	IN
cord-017954-vobslprh	249	7	multiple	multiple	JJ
cord-017954-vobslprh	249	8	sclerosis	sclerosis	NN
cord-017954-vobslprh	250	1	Myelin	myelin	NN
cord-017954-vobslprh	250	2	antigenspecific	antigenspecific	NN
cord-017954-vobslprh	250	3	CD8þ	CD8þ	NNP
cord-017954-vobslprh	250	4	T	T	NNP
cord-017954-vobslprh	250	5	cells	cell	NNS
cord-017954-vobslprh	250	6	are	be	VBP
cord-017954-vobslprh	250	7	encephalitogenic	encephalitogenic	JJ
cord-017954-vobslprh	250	8	and	and	CC
cord-017954-vobslprh	250	9	produce	produce	VBP
cord-017954-vobslprh	250	10	severe	severe	JJ
cord-017954-vobslprh	250	11	disease	disease	NN
cord-017954-vobslprh	250	12	in	in	IN
cord-017954-vobslprh	250	13	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	250	14	mice	mouse	NNS
cord-017954-vobslprh	250	15	Neuroantigen	Neuroantigen	NNP
cord-017954-vobslprh	250	16	-	-	HYPH
cord-017954-vobslprh	250	17	specific	specific	JJ
cord-017954-vobslprh	250	18	autoregulatory	autoregulatory	NN
cord-017954-vobslprh	250	19	CD8þ	CD8þ	NNP
cord-017954-vobslprh	250	20	T	T	NNP
cord-017954-vobslprh	250	21	cells	cell	NNS
cord-017954-vobslprh	251	1	inhibit	inhibit	VB
cord-017954-vobslprh	251	2	autoimmune	autoimmune	JJ
cord-017954-vobslprh	251	3	demyelination	demyelination	NN
cord-017954-vobslprh	251	4	through	through	IN
cord-017954-vobslprh	251	5	modulation	modulation	NN
cord-017954-vobslprh	251	6	of	of	IN
cord-017954-vobslprh	251	7	dendritic	dendritic	JJ
cord-017954-vobslprh	251	8	cell	cell	NN
cord-017954-vobslprh	251	9	function	function	NN
cord-017954-vobslprh	251	10	IL-15-dependent	IL-15-dependent	NNP
cord-017954-vobslprh	251	11	CD8þ	CD8þ	NNP
cord-017954-vobslprh	251	12	CD122þ	CD122þ	NNP
cord-017954-vobslprh	251	13	T	t	NN
cord-017954-vobslprh	251	14	cells	cell	NNS
cord-017954-vobslprh	251	15	ameliorate	ameliorate	VBP
cord-017954-vobslprh	251	16	experimental	experimental	JJ
cord-017954-vobslprh	251	17	autoimmune	autoimmune	JJ
cord-017954-vobslprh	251	18	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	251	19	by	by	IN
cord-017954-vobslprh	251	20	modulating	modulate	VBG
cord-017954-vobslprh	251	21	IL-17	IL-17	NNP
cord-017954-vobslprh	251	22	production	production	NN
cord-017954-vobslprh	251	23	by	by	IN
cord-017954-vobslprh	251	24	CD4þ	CD4þ	NNP
cord-017954-vobslprh	251	25	T	T	NNP
cord-017954-vobslprh	251	26	cells	cell	NNS
cord-017954-vobslprh	251	27	CD8	CD8	NNP
cord-017954-vobslprh	251	28	T	T	NNP
cord-017954-vobslprh	251	29	cell	cell	NN
cord-017954-vobslprh	251	30	responses	response	NNS
cord-017954-vobslprh	251	31	to	to	IN
cord-017954-vobslprh	251	32	myelin	myelin	NN
cord-017954-vobslprh	251	33	oligodendrocyte	oligodendrocyte	NNP
cord-017954-vobslprh	251	34	glycoprotein	glycoprotein	NN
cord-017954-vobslprh	251	35	-	-	HYPH
cord-017954-vobslprh	251	36	derived	derive	VBN
cord-017954-vobslprh	251	37	peptides	peptide	NNS
cord-017954-vobslprh	251	38	in	in	IN
cord-017954-vobslprh	251	39	humanized	humanize	VBN
cord-017954-vobslprh	251	40	HLA	HLA	NNP
cord-017954-vobslprh	251	41	-	-	HYPH
cord-017954-vobslprh	251	42	A*0201-transgenic	A*0201-transgenic	NNP
cord-017954-vobslprh	251	43	mice	mouse	NNS
cord-017954-vobslprh	251	44	Mouse	mouse	NN
cord-017954-vobslprh	251	45	models	model	NNS
cord-017954-vobslprh	251	46	for	for	IN
cord-017954-vobslprh	251	47	multiple	multiple	JJ
cord-017954-vobslprh	251	48	sclerosis	sclerosis	NN
cord-017954-vobslprh	251	49	:	:	:
cord-017954-vobslprh	251	50	historical	historical	JJ
cord-017954-vobslprh	251	51	facts	fact	NNS
cord-017954-vobslprh	251	52	and	and	CC
cord-017954-vobslprh	251	53	future	future	JJ
cord-017954-vobslprh	251	54	implications	implication	NNS
cord-017954-vobslprh	251	55	B	b	NN
cord-017954-vobslprh	251	56	-	-	HYPH
cord-017954-vobslprh	251	57	cell	cell	NN
cord-017954-vobslprh	251	58	depletion	depletion	NN
cord-017954-vobslprh	251	59	with	with	IN
cord-017954-vobslprh	251	60	rituximab	rituximab	NN
cord-017954-vobslprh	251	61	in	in	IN
cord-017954-vobslprh	251	62	relapsing	relapse	VBG
cord-017954-vobslprh	251	63	-	-	HYPH
cord-017954-vobslprh	251	64	remitting	remit	VBG
cord-017954-vobslprh	251	65	multiple	multiple	JJ
cord-017954-vobslprh	251	66	sclerosis	sclerosis	NN
cord-017954-vobslprh	251	67	Monocytes	monocyte	NNS
cord-017954-vobslprh	251	68	/	/	SYM
cord-017954-vobslprh	251	69	macrophages	macrophage	NNS
cord-017954-vobslprh	251	70	isolated	isolate	VBN
cord-017954-vobslprh	251	71	from	from	IN
cord-017954-vobslprh	251	72	the	the	DT
cord-017954-vobslprh	251	73	mouse	mouse	NN
cord-017954-vobslprh	251	74	central	central	JJ
cord-017954-vobslprh	251	75	nervous	nervous	JJ
cord-017954-vobslprh	251	76	system	system	NN
cord-017954-vobslprh	251	77	contain	contain	VBP
cord-017954-vobslprh	251	78	infectious	infectious	JJ
cord-017954-vobslprh	251	79	Theiler	Theiler	NNP
cord-017954-vobslprh	251	80	's	's	POS
cord-017954-vobslprh	251	81	murine	murine	JJ
cord-017954-vobslprh	251	82	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	251	83	virus	virus	NN
cord-017954-vobslprh	251	84	(	(	-LRB-
cord-017954-vobslprh	251	85	TMEV	TMEV	NNP
cord-017954-vobslprh	251	86	)	)	-RRB-
cord-017954-vobslprh	252	1	Split	split	JJ
cord-017954-vobslprh	252	2	tolerance	tolerance	NN
cord-017954-vobslprh	252	3	of	of	IN
cord-017954-vobslprh	252	4	Th1	th1	NN
cord-017954-vobslprh	252	5	and	and	CC
cord-017954-vobslprh	252	6	Th2	th2	CD
cord-017954-vobslprh	252	7	cells	cell	NNS
cord-017954-vobslprh	252	8	in	in	IN
cord-017954-vobslprh	252	9	tolerance	tolerance	NN
cord-017954-vobslprh	252	10	to	to	IN
cord-017954-vobslprh	252	11	Theiler	Theiler	NNP
cord-017954-vobslprh	252	12	's	's	POS
cord-017954-vobslprh	252	13	murine	murine	JJ
cord-017954-vobslprh	252	14	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	252	15	virus	virus	NN
cord-017954-vobslprh	252	16	Class	Class	NNP
cord-017954-vobslprh	252	17	II	II	NNP
cord-017954-vobslprh	252	18	-	-	HYPH
cord-017954-vobslprh	252	19	restricted	restrict	VBN
cord-017954-vobslprh	252	20	T	t	NN
cord-017954-vobslprh	252	21	cell	cell	NN
cord-017954-vobslprh	252	22	responses	response	NNS
cord-017954-vobslprh	252	23	in	in	IN
cord-017954-vobslprh	252	24	Theiler	Theiler	NNP
cord-017954-vobslprh	252	25	's	's	POS
cord-017954-vobslprh	252	26	murine	murine	JJ
cord-017954-vobslprh	252	27	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	252	28	virus	virus	NN
cord-017954-vobslprh	252	29	(	(	-LRB-
cord-017954-vobslprh	252	30	TMEV)-induced	tmev)-induced	JJ
cord-017954-vobslprh	252	31	demyelinating	demyelinating	NN
cord-017954-vobslprh	252	32	disease	disease	NN
cord-017954-vobslprh	252	33	.	.	.
cord-017954-vobslprh	253	1	III	III	NNP
cord-017954-vobslprh	253	2	.	.	.
cord-017954-vobslprh	254	1	Failure	failure	NN
cord-017954-vobslprh	254	2	of	of	IN
cord-017954-vobslprh	254	3	neuroantigen	neuroantigen	NN
cord-017954-vobslprh	254	4	-	-	HYPH
cord-017954-vobslprh	254	5	specific	specific	JJ
cord-017954-vobslprh	254	6	immune	immune	JJ
cord-017954-vobslprh	254	7	tolerance	tolerance	NN
cord-017954-vobslprh	254	8	to	to	TO
cord-017954-vobslprh	254	9	affect	affect	VB
cord-017954-vobslprh	254	10	the	the	DT
cord-017954-vobslprh	254	11	clinical	clinical	JJ
cord-017954-vobslprh	254	12	course	course	NN
cord-017954-vobslprh	254	13	of	of	IN
cord-017954-vobslprh	254	14	demyelination	demyelination	NN
cord-017954-vobslprh	254	15	Pathology	Pathology	NNP
cord-017954-vobslprh	254	16	of	of	IN
cord-017954-vobslprh	254	17	the	the	DT
cord-017954-vobslprh	254	18	early	early	JJ
cord-017954-vobslprh	254	19	lesion	lesion	NN
cord-017954-vobslprh	254	20	in	in	IN
cord-017954-vobslprh	254	21	multiple	multiple	JJ
cord-017954-vobslprh	254	22	sclerosis	sclerosis	NN
cord-017954-vobslprh	254	23	Primary	primary	JJ
cord-017954-vobslprh	254	24	demyelination	demyelination	NN
cord-017954-vobslprh	254	25	in	in	IN
cord-017954-vobslprh	254	26	Theiler	Theiler	NNP
cord-017954-vobslprh	254	27	's	's	POS
cord-017954-vobslprh	254	28	virus	virus	NN
cord-017954-vobslprh	254	29	infection	infection	NN
cord-017954-vobslprh	254	30	.	.	.
cord-017954-vobslprh	255	1	An	an	DT
cord-017954-vobslprh	255	2	ultrastructural	ultrastructural	JJ
cord-017954-vobslprh	255	3	study	study	NN
cord-017954-vobslprh	255	4	Expansion	Expansion	NNP
cord-017954-vobslprh	255	5	by	by	IN
cord-017954-vobslprh	255	6	self	self	NN
cord-017954-vobslprh	255	7	antigen	antigen	NN
cord-017954-vobslprh	255	8	is	be	VBZ
cord-017954-vobslprh	255	9	necessary	necessary	JJ
cord-017954-vobslprh	255	10	for	for	IN
cord-017954-vobslprh	255	11	the	the	DT
cord-017954-vobslprh	255	12	induction	induction	NN
cord-017954-vobslprh	255	13	of	of	IN
cord-017954-vobslprh	255	14	experimental	experimental	JJ
cord-017954-vobslprh	255	15	autoimmune	autoimmune	JJ
cord-017954-vobslprh	255	16	encephalomyelitis	encephalomyelitis	NN
cord-017954-vobslprh	255	17	by	by	IN
cord-017954-vobslprh	255	18	T	T	NNP
cord-017954-vobslprh	255	19	cells	cell	NNS
cord-017954-vobslprh	255	20	primed	prime	VBN
cord-017954-vobslprh	255	21	with	with	IN
cord-017954-vobslprh	255	22	a	a	DT
cord-017954-vobslprh	255	23	cross	cross	JJ
cord-017954-vobslprh	255	24	-	-	JJ
cord-017954-vobslprh	255	25	reactive	reactive	JJ
cord-017954-vobslprh	255	26	environmental	environmental	JJ
cord-017954-vobslprh	255	27	antigen	antigen	NN
cord-017954-vobslprh	255	28	Molecular	molecular	JJ
cord-017954-vobslprh	255	29	mimicry	mimicry	NN
cord-017954-vobslprh	255	30	in	in	IN
cord-017954-vobslprh	255	31	T	T	NNP
cord-017954-vobslprh	255	32	cell	cell	NN
cord-017954-vobslprh	255	33	-	-	HYPH
cord-017954-vobslprh	255	34	mediated	mediate	VBN
cord-017954-vobslprh	255	35	autoimmunity	autoimmunity	NN
cord-017954-vobslprh	255	36	:	:	:
cord-017954-vobslprh	255	37	viral	viral	JJ
cord-017954-vobslprh	255	38	peptides	peptide	NNS
cord-017954-vobslprh	255	39	activate	activate	VBP
cord-017954-vobslprh	255	40	human	human	JJ
cord-017954-vobslprh	255	41	T	t	NN
cord-017954-vobslprh	255	42	cell	cell	NN
cord-017954-vobslprh	255	43	clones	clone	NNS
cord-017954-vobslprh	255	44	specific	specific	JJ
cord-017954-vobslprh	255	45	for	for	IN
cord-017954-vobslprh	255	46	myelin	myelin	JJ
cord-017954-vobslprh	255	47	basic	basic	JJ
cord-017954-vobslprh	255	48	protein	protein	NN
cord-017954-vobslprh	256	1	A	a	DT
cord-017954-vobslprh	256	2	virus	virus	NN
cord-017954-vobslprh	256	3	-	-	HYPH
cord-017954-vobslprh	256	4	induced	induce	VBN
cord-017954-vobslprh	256	5	molecular	molecular	JJ
cord-017954-vobslprh	256	6	mimicry	mimicry	NN
cord-017954-vobslprh	256	7	model	model	NN
cord-017954-vobslprh	256	8	of	of	IN
cord-017954-vobslprh	256	9	multiple	multiple	JJ
cord-017954-vobslprh	256	10	sclerosis	sclerosis	NN
cord-017954-vobslprh	256	11	Viral	viral	JJ
cord-017954-vobslprh	256	12	delivery	delivery	NN
cord-017954-vobslprh	256	13	of	of	IN
cord-017954-vobslprh	256	14	an	an	DT
cord-017954-vobslprh	256	15	epitope	epitope	NN
cord-017954-vobslprh	256	16	from	from	IN
cord-017954-vobslprh	256	17	Haemophilus	Haemophilus	NNP
cord-017954-vobslprh	256	18	influenzae	influenzae	NN
cord-017954-vobslprh	256	19	induces	induce	VBZ
cord-017954-vobslprh	256	20	central	central	JJ
cord-017954-vobslprh	256	21	nervous	nervous	JJ
cord-017954-vobslprh	256	22	system	system	NN
cord-017954-vobslprh	256	23	autoimmune	autoimmune	JJ
cord-017954-vobslprh	256	24	disease	disease	NN
cord-017954-vobslprh	256	25	by	by	IN
cord-017954-vobslprh	256	26	molecular	molecular	JJ
cord-017954-vobslprh	256	27	mimicry	mimicry	NN
cord-017954-vobslprh	257	1	Structural	structural	JJ
cord-017954-vobslprh	257	2	requirements	requirement	NNS
cord-017954-vobslprh	257	3	for	for	IN
cord-017954-vobslprh	257	4	initiation	initiation	NN
cord-017954-vobslprh	257	5	of	of	IN
cord-017954-vobslprh	257	6	cross	cross	NN
cord-017954-vobslprh	257	7	-	-	NN
cord-017954-vobslprh	257	8	reactivity	reactivity	NN
cord-017954-vobslprh	257	9	and	and	CC
cord-017954-vobslprh	257	10	CNS	CNS	NNP
cord-017954-vobslprh	257	11	autoimmunity	autoimmunity	NN
cord-017954-vobslprh	257	12	with	with	IN
cord-017954-vobslprh	257	13	a	a	DT
cord-017954-vobslprh	257	14	PLP139	PLP139	NNP
cord-017954-vobslprh	257	15	-	-	HYPH
cord-017954-vobslprh	257	16	151	151	CD
cord-017954-vobslprh	257	17	mimic	mimic	VBP
cord-017954-vobslprh	257	18	peptide	peptide	NN
cord-017954-vobslprh	257	19	derived	derive	VBN
cord-017954-vobslprh	257	20	from	from	IN
cord-017954-vobslprh	257	21	murine	murine	JJ
cord-017954-vobslprh	257	22	hepatitis	hepatitis	NN
cord-017954-vobslprh	257	23	virus	virus	NN
cord-017954-vobslprh	257	24	Long	long	JJ
cord-017954-vobslprh	257	25	-	-	HYPH
cord-017954-vobslprh	257	26	term	term	NN
cord-017954-vobslprh	257	27	effects	effect	NNS
cord-017954-vobslprh	257	28	of	of	IN
cord-017954-vobslprh	257	29	Semliki	Semliki	NNP
cord-017954-vobslprh	257	30	Forest	Forest	NNP
cord-017954-vobslprh	257	31	virus	virus	NN
cord-017954-vobslprh	257	32	infection	infection	NN
cord-017954-vobslprh	257	33	in	in	IN
cord-017954-vobslprh	257	34	the	the	DT
cord-017954-vobslprh	257	35	mouse	mouse	NN
cord-017954-vobslprh	257	36	central	central	JJ
cord-017954-vobslprh	257	37	nervous	nervous	JJ
cord-017954-vobslprh	257	38	system	system	NN
cord-017954-vobslprh	257	39	Predisposition	predisposition	NN
cord-017954-vobslprh	257	40	to	to	IN
cord-017954-vobslprh	257	41	EAE	EAE	NNP
cord-017954-vobslprh	257	42	induction	induction	NN
cord-017954-vobslprh	257	43	in	in	IN
cord-017954-vobslprh	257	44	resistant	resistant	JJ
cord-017954-vobslprh	257	45	mice	mouse	NNS
cord-017954-vobslprh	257	46	by	by	IN
cord-017954-vobslprh	257	47	prior	prior	JJ
cord-017954-vobslprh	257	48	infection	infection	NN
cord-017954-vobslprh	257	49	with	with	IN
cord-017954-vobslprh	257	50	Semliki	Semliki	NNP
cord-017954-vobslprh	257	51	Forest	Forest	NNP
cord-017954-vobslprh	257	52	virus	virus	NN
cord-017954-vobslprh	258	1	The	the	DT
cord-017954-vobslprh	258	2	pathogenicity	pathogenicity	NN
cord-017954-vobslprh	258	3	of	of	IN
cord-017954-vobslprh	258	4	the	the	DT
cord-017954-vobslprh	258	5	M9	M9	NNP
cord-017954-vobslprh	258	6	mutant	mutant	NN
cord-017954-vobslprh	258	7	of	of	IN
cord-017954-vobslprh	258	8	Semliki	Semliki	NNP
cord-017954-vobslprh	258	9	Forest	Forest	NNP
cord-017954-vobslprh	258	10	virus	virus	NN
cord-017954-vobslprh	258	11	in	in	IN
cord-017954-vobslprh	258	12	immune	immune	NN
cord-017954-vobslprh	258	13	-	-	HYPH
cord-017954-vobslprh	258	14	compromised	compromised	JJ
cord-017954-vobslprh	258	15	mice	mouse	NNS
cord-017954-vobslprh	258	16	Semliki	Semliki	NNP
cord-017954-vobslprh	258	17	Forest	Forest	NNP
cord-017954-vobslprh	258	18	virus	virus	NN
cord-017954-vobslprh	258	19	induced	induce	VBN
cord-017954-vobslprh	258	20	,	,	,
cord-017954-vobslprh	258	21	immune	immune	JJ
cord-017954-vobslprh	258	22	mediated	mediate	VBN
cord-017954-vobslprh	258	23	demyelination	demyelination	NN
cord-017954-vobslprh	258	24	:	:	:
cord-017954-vobslprh	258	25	the	the	DT
cord-017954-vobslprh	258	26	effect	effect	NN
cord-017954-vobslprh	258	27	of	of	IN
cord-017954-vobslprh	258	28	irradiation	irradiation	NN
cord-017954-vobslprh	258	29	Dissociation	dissociation	NN
cord-017954-vobslprh	258	30	of	of	IN
cord-017954-vobslprh	258	31	demyelination	demyelination	NN
cord-017954-vobslprh	258	32	and	and	CC
cord-017954-vobslprh	258	33	viral	viral	JJ
cord-017954-vobslprh	258	34	clearance	clearance	NN
cord-017954-vobslprh	258	35	in	in	IN
cord-017954-vobslprh	258	36	congenitally	congenitally	RB
cord-017954-vobslprh	258	37	immunodeficient	immunodeficient	JJ
cord-017954-vobslprh	258	38	mice	mouse	NNS
cord-017954-vobslprh	258	39	infected	infect	VBN
cord-017954-vobslprh	258	40	with	with	IN
cord-017954-vobslprh	258	41	murine	murine	JJ
cord-017954-vobslprh	258	42	coronavirus	coronavirus	NN
cord-017954-vobslprh	259	1	JHM	JHM	NNP
cord-017954-vobslprh	260	1	The	the	DT
cord-017954-vobslprh	260	2	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	260	3	of	of	IN
cord-017954-vobslprh	260	4	murine	murine	JJ
cord-017954-vobslprh	260	5	coronavirus	coronavirus	NN
cord-017954-vobslprh	260	6	infection	infection	NN
cord-017954-vobslprh	260	7	of	of	IN
cord-017954-vobslprh	260	8	the	the	DT
cord-017954-vobslprh	260	9	central	central	JJ
cord-017954-vobslprh	260	10	nervous	nervous	JJ
cord-017954-vobslprh	260	11	system	system	NN
cord-017954-vobslprh	260	12	Epitope	Epitope	NNP
cord-017954-vobslprh	260	13	spreading	spread	VBG
cord-017954-vobslprh	260	14	and	and	CC
cord-017954-vobslprh	260	15	molecular	molecular	JJ
cord-017954-vobslprh	260	16	mimicry	mimicry	NN
cord-017954-vobslprh	260	17	as	as	IN
cord-017954-vobslprh	260	18	triggers	trigger	NNS
cord-017954-vobslprh	260	19	of	of	IN
cord-017954-vobslprh	260	20	autoimmunity	autoimmunity	NN
cord-017954-vobslprh	260	21	in	in	IN
cord-017954-vobslprh	260	22	the	the	DT
cord-017954-vobslprh	260	23	Theiler	Theiler	NNP
cord-017954-vobslprh	260	24	's	's	POS
cord-017954-vobslprh	260	25	virus	virus	NN
cord-017954-vobslprh	260	26	-	-	HYPH
cord-017954-vobslprh	260	27	induced	induce	VBN
cord-017954-vobslprh	260	28	demyelinating	demyelinate	VBG
cord-017954-vobslprh	260	29	disease	disease	NN
cord-017954-vobslprh	260	30	model	model	NN
cord-017954-vobslprh	260	31	of	of	IN
cord-017954-vobslprh	260	32	multiple	multiple	JJ
cord-017954-vobslprh	260	33	sclerosis	sclerosis	NN
cord-017954-vobslprh	260	34	Serologic	Serologic	NNP
cord-017954-vobslprh	260	35	evidence	evidence	NN
cord-017954-vobslprh	260	36	of	of	IN
cord-017954-vobslprh	260	37	previous	previous	JJ
cord-017954-vobslprh	260	38	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	260	39	jejuni	jejuni	NNP
cord-017954-vobslprh	260	40	infection	infection	NN
cord-017954-vobslprh	260	41	in	in	IN
cord-017954-vobslprh	260	42	patients	patient	NNS
cord-017954-vobslprh	260	43	with	with	IN
cord-017954-vobslprh	260	44	the	the	DT
cord-017954-vobslprh	260	45	Guillain	Guillain	NNP
cord-017954-vobslprh	260	46	-	-	HYPH
cord-017954-vobslprh	260	47	Barre	Barre	NNP
cord-017954-vobslprh	260	48	'	'	POS
cord-017954-vobslprh	260	49	syndrome	syndrome	NN
cord-017954-vobslprh	260	50	Guillain	Guillain	NNP
cord-017954-vobslprh	260	51	-	-	HYPH
cord-017954-vobslprh	260	52	barré	barré	NNP
cord-017954-vobslprh	260	53	syndrome	syndrome	NNP
cord-017954-vobslprh	260	54	animal	animal	NNP
cord-017954-vobslprh	260	55	model	model	NN
cord-017954-vobslprh	260	56	:	:	:
cord-017954-vobslprh	260	57	the	the	DT
cord-017954-vobslprh	260	58	first	first	JJ
cord-017954-vobslprh	260	59	proof	proof	NN
cord-017954-vobslprh	260	60	of	of	IN
cord-017954-vobslprh	260	61	molecular	molecular	JJ
cord-017954-vobslprh	260	62	mimicry	mimicry	NN
cord-017954-vobslprh	260	63	in	in	IN
cord-017954-vobslprh	260	64	human	human	JJ
cord-017954-vobslprh	260	65	autoimmune	autoimmune	JJ
cord-017954-vobslprh	260	66	disorder	disorder	NN
cord-017954-vobslprh	260	67	Pathogenesis	Pathogenesis	NNP
cord-017954-vobslprh	260	68	of	of	IN
cord-017954-vobslprh	260	69	Guillain	Guillain	NNP
cord-017954-vobslprh	260	70	-	-	HYPH
cord-017954-vobslprh	260	71	Barré	Barré	NNP
cord-017954-vobslprh	260	72	syndrome	syndrome	NN
cord-017954-vobslprh	261	1	The	the	DT
cord-017954-vobslprh	261	2	role	role	NN
cord-017954-vobslprh	261	3	of	of	IN
cord-017954-vobslprh	261	4	cytokines	cytokine	NNS
cord-017954-vobslprh	261	5	in	in	IN
cord-017954-vobslprh	261	6	Guillain	Guillain	NNP
cord-017954-vobslprh	261	7	-	-	HYPH
cord-017954-vobslprh	261	8	Barré	Barré	NNP
cord-017954-vobslprh	261	9	syndrome	syndrome	NN
cord-017954-vobslprh	261	10	Acute	Acute	NNP
cord-017954-vobslprh	261	11	immunoinflammatory	immunoinflammatory	NNP
cord-017954-vobslprh	261	12	neuropathy	neuropathy	NN
cord-017954-vobslprh	261	13	:	:	:
cord-017954-vobslprh	261	14	update	update	VB
cord-017954-vobslprh	261	15	on	on	IN
cord-017954-vobslprh	261	16	Guillain	Guillain	NNP
cord-017954-vobslprh	261	17	-	-	HYPH
cord-017954-vobslprh	261	18	Barré	Barré	NNP
cord-017954-vobslprh	261	19	syndrome	syndrome	NN
cord-017954-vobslprh	262	1	From	from	IN
cord-017954-vobslprh	262	2	bench	bench	NN
cord-017954-vobslprh	262	3	to	to	IN
cord-017954-vobslprh	262	4	bedside	bedside	NN
cord-017954-vobslprh	262	5	-	-	HYPH
cord-017954-vobslprh	262	6	experimental	experimental	JJ
cord-017954-vobslprh	262	7	rationale	rationale	NN
cord-017954-vobslprh	262	8	for	for	IN
cord-017954-vobslprh	262	9	immune	immune	JJ
cord-017954-vobslprh	262	10	-	-	HYPH
cord-017954-vobslprh	262	11	specific	specific	JJ
cord-017954-vobslprh	262	12	therapies	therapy	NNS
cord-017954-vobslprh	262	13	in	in	IN
cord-017954-vobslprh	262	14	the	the	DT
cord-017954-vobslprh	262	15	inflamed	inflamed	JJ
cord-017954-vobslprh	262	16	peripheral	peripheral	JJ
cord-017954-vobslprh	262	17	nerve	nerve	NN
cord-017954-vobslprh	262	18	Pathology	Pathology	NNP
cord-017954-vobslprh	262	19	of	of	IN
cord-017954-vobslprh	262	20	the	the	DT
cord-017954-vobslprh	262	21	motor	motor	NN
cord-017954-vobslprh	262	22	-	-	HYPH
cord-017954-vobslprh	262	23	sensory	sensory	JJ
cord-017954-vobslprh	262	24	axonal	axonal	JJ
cord-017954-vobslprh	262	25	Guillain	Guillain	NNP
cord-017954-vobslprh	262	26	-	-	HYPH
cord-017954-vobslprh	262	27	Barre	Barre	NNP
cord-017954-vobslprh	262	28	'	'	POS
cord-017954-vobslprh	262	29	syndrome	syndrome	NN
cord-017954-vobslprh	263	1	Allergic	allergic	JJ
cord-017954-vobslprh	263	2	neuritis	neuritis	NN
cord-017954-vobslprh	263	3	:	:	:
cord-017954-vobslprh	263	4	an	an	DT
cord-017954-vobslprh	263	5	experimental	experimental	JJ
cord-017954-vobslprh	263	6	disease	disease	NN
cord-017954-vobslprh	263	7	of	of	IN
cord-017954-vobslprh	263	8	rabbits	rabbit	NNS
cord-017954-vobslprh	263	9	induced	induce	VBN
cord-017954-vobslprh	263	10	by	by	IN
cord-017954-vobslprh	263	11	the	the	DT
cord-017954-vobslprh	263	12	injection	injection	NN
cord-017954-vobslprh	263	13	of	of	IN
cord-017954-vobslprh	263	14	peripheral	peripheral	JJ
cord-017954-vobslprh	263	15	nervous	nervous	JJ
cord-017954-vobslprh	263	16	tissue	tissue	NN
cord-017954-vobslprh	263	17	and	and	CC
cord-017954-vobslprh	263	18	adjuvants	adjuvant	NNS
cord-017954-vobslprh	263	19	Identification	identification	NN
cord-017954-vobslprh	263	20	of	of	IN
cord-017954-vobslprh	263	21	the	the	DT
cord-017954-vobslprh	263	22	neuritogen	neuritogen	NNP
cord-017954-vobslprh	263	23	for	for	IN
cord-017954-vobslprh	263	24	experimental	experimental	JJ
cord-017954-vobslprh	263	25	allergic	allergic	JJ
cord-017954-vobslprh	263	26	neuritis	neuritis	NN
cord-017954-vobslprh	264	1	P0	p0	NN
cord-017954-vobslprh	264	2	myelin	myelin	NN
cord-017954-vobslprh	264	3	protein	protein	NN
cord-017954-vobslprh	264	4	produces	produce	VBZ
cord-017954-vobslprh	264	5	experimental	experimental	JJ
cord-017954-vobslprh	264	6	allergic	allergic	JJ
cord-017954-vobslprh	264	7	neuritis	neuritis	NN
cord-017954-vobslprh	264	8	in	in	IN
cord-017954-vobslprh	264	9	Lewis	Lewis	NNP
cord-017954-vobslprh	264	10	rats	rat	NNS
cord-017954-vobslprh	264	11	Sequential	sequential	JJ
cord-017954-vobslprh	264	12	expression	expression	NN
cord-017954-vobslprh	264	13	of	of	IN
cord-017954-vobslprh	264	14	chemokines	chemokine	NNS
cord-017954-vobslprh	264	15	in	in	IN
cord-017954-vobslprh	264	16	experimental	experimental	JJ
cord-017954-vobslprh	264	17	autoimmune	autoimmune	JJ
cord-017954-vobslprh	264	18	neuritis	neuritis	NN
cord-017954-vobslprh	264	19	Chemokines	Chemokines	NNPS
cord-017954-vobslprh	264	20	and	and	CC
cord-017954-vobslprh	264	21	peripheral	peripheral	JJ
cord-017954-vobslprh	264	22	nerve	nerve	NN
cord-017954-vobslprh	264	23	demyelination	demyelination	NN
cord-017954-vobslprh	264	24	Cytokine	cytokine	NN
cord-017954-vobslprh	264	25	production	production	NN
cord-017954-vobslprh	264	26	and	and	CC
cord-017954-vobslprh	264	27	the	the	DT
cord-017954-vobslprh	264	28	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	264	29	of	of	IN
cord-017954-vobslprh	264	30	experimental	experimental	JJ
cord-017954-vobslprh	264	31	autoimmune	autoimmune	JJ
cord-017954-vobslprh	264	32	neuritis	neuritis	NN
cord-017954-vobslprh	264	33	and	and	CC
cord-017954-vobslprh	264	34	Guillain	Guillain	NNP
cord-017954-vobslprh	264	35	-	-	HYPH
cord-017954-vobslprh	264	36	Barré	Barré	NNP
cord-017954-vobslprh	264	37	syndrome	syndrome	NN
cord-017954-vobslprh	265	1	The	the	DT
cord-017954-vobslprh	265	2	role	role	NN
cord-017954-vobslprh	265	3	of	of	IN
cord-017954-vobslprh	265	4	the	the	DT
cord-017954-vobslprh	265	5	very	very	RB
cord-017954-vobslprh	265	6	late	late	JJ
cord-017954-vobslprh	265	7	antigen-4	antigen-4	NNP
cord-017954-vobslprh	265	8	and	and	CC
cord-017954-vobslprh	265	9	its	-PRON-	PRP$
cord-017954-vobslprh	265	10	counterligand	counterligand	JJ
cord-017954-vobslprh	265	11	vascular	vascular	JJ
cord-017954-vobslprh	265	12	cell	cell	NN
cord-017954-vobslprh	265	13	adhesion	adhesion	NN
cord-017954-vobslprh	265	14	molecule-1	molecule-1	NNP
cord-017954-vobslprh	265	15	in	in	IN
cord-017954-vobslprh	265	16	the	the	DT
cord-017954-vobslprh	265	17	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	265	18	of	of	IN
cord-017954-vobslprh	265	19	experimental	experimental	JJ
cord-017954-vobslprh	265	20	autoimmune	autoimmune	JJ
cord-017954-vobslprh	265	21	neuritis	neuritis	NN
cord-017954-vobslprh	265	22	of	of	IN
cord-017954-vobslprh	265	23	the	the	DT
cord-017954-vobslprh	265	24	Lewis	Lewis	NNP
cord-017954-vobslprh	265	25	rat	rat	NN
cord-017954-vobslprh	266	1	The	the	DT
cord-017954-vobslprh	266	2	role	role	NN
cord-017954-vobslprh	266	3	of	of	IN
cord-017954-vobslprh	266	4	interferon	interferon	NN
cord-017954-vobslprh	266	5	-	-	HYPH
cord-017954-vobslprh	266	6	gamma	gamma	NN
cord-017954-vobslprh	266	7	in	in	IN
cord-017954-vobslprh	266	8	the	the	DT
cord-017954-vobslprh	266	9	pathogenesis	pathogenesis	NN
cord-017954-vobslprh	266	10	of	of	IN
cord-017954-vobslprh	266	11	experimental	experimental	JJ
cord-017954-vobslprh	266	12	autoimmune	autoimmune	JJ
cord-017954-vobslprh	266	13	disease	disease	NN
cord-017954-vobslprh	266	14	of	of	IN
cord-017954-vobslprh	266	15	the	the	DT
cord-017954-vobslprh	266	16	peripheral	peripheral	JJ
cord-017954-vobslprh	266	17	nervous	nervous	JJ
cord-017954-vobslprh	266	18	system	system	NN
cord-017954-vobslprh	266	19	Experimental	experimental	JJ
cord-017954-vobslprh	266	20	allergic	allergic	JJ
cord-017954-vobslprh	266	21	neuritis	neuritis	NN
cord-017954-vobslprh	266	22	in	in	IN
cord-017954-vobslprh	266	23	the	the	DT
cord-017954-vobslprh	266	24	SJL	SJL	NNP
cord-017954-vobslprh	266	25	/	/	SYM
cord-017954-vobslprh	266	26	J	J	NNP
cord-017954-vobslprh	266	27	mouse	mouse	NN
cord-017954-vobslprh	266	28	:	:	:
cord-017954-vobslprh	266	29	dysfunction	dysfunction	NN
cord-017954-vobslprh	266	30	of	of	IN
cord-017954-vobslprh	266	31	peripheral	peripheral	JJ
cord-017954-vobslprh	266	32	nerve	nerve	NN
cord-017954-vobslprh	266	33	without	without	IN
cord-017954-vobslprh	266	34	clinical	clinical	JJ
cord-017954-vobslprh	266	35	signs	sign	NNS
cord-017954-vobslprh	266	36	Experimental	experimental	JJ
cord-017954-vobslprh	266	37	allergic	allergic	JJ
cord-017954-vobslprh	266	38	neuritis	neuritis	NN
cord-017954-vobslprh	266	39	in	in	IN
cord-017954-vobslprh	266	40	the	the	DT
cord-017954-vobslprh	266	41	SJL	SJL	NNP
cord-017954-vobslprh	266	42	/	/	SYM
cord-017954-vobslprh	266	43	J	J	NNP
cord-017954-vobslprh	266	44	mouse	mouse	NN
cord-017954-vobslprh	266	45	:	:	:
cord-017954-vobslprh	266	46	induction	induction	NN
cord-017954-vobslprh	266	47	of	of	IN
cord-017954-vobslprh	266	48	severe	severe	JJ
cord-017954-vobslprh	266	49	and	and	CC
cord-017954-vobslprh	266	50	reproducible	reproducible	JJ
cord-017954-vobslprh	266	51	disease	disease	NN
cord-017954-vobslprh	266	52	with	with	IN
cord-017954-vobslprh	266	53	bovine	bovine	JJ
cord-017954-vobslprh	266	54	peripheral	peripheral	JJ
cord-017954-vobslprh	266	55	nerve	nerve	NN
cord-017954-vobslprh	266	56	myelin	myelin	NN
cord-017954-vobslprh	266	57	and	and	CC
cord-017954-vobslprh	266	58	pertussis	pertussis	NN
cord-017954-vobslprh	266	59	toxin	toxin	NN
cord-017954-vobslprh	266	60	with	with	IN
cord-017954-vobslprh	266	61	or	or	CC
cord-017954-vobslprh	266	62	without	without	IN
cord-017954-vobslprh	266	63	interleukin-12	interleukin-12	NFP
cord-017954-vobslprh	266	64	P0	p0	NN
cord-017954-vobslprh	266	65	protein	protein	NN
cord-017954-vobslprh	266	66	peptide	peptide	NN
cord-017954-vobslprh	266	67	180	180	CD
cord-017954-vobslprh	266	68	-	-	SYM
cord-017954-vobslprh	266	69	199	199	CD
cord-017954-vobslprh	266	70	together	together	RB
cord-017954-vobslprh	266	71	with	with	IN
cord-017954-vobslprh	266	72	pertussis	pertussis	NN
cord-017954-vobslprh	266	73	toxin	toxin	NN
cord-017954-vobslprh	266	74	induces	induce	VBZ
cord-017954-vobslprh	266	75	experimental	experimental	JJ
cord-017954-vobslprh	266	76	autoimmune	autoimmune	JJ
cord-017954-vobslprh	266	77	neuritis	neuritis	NN
cord-017954-vobslprh	266	78	in	in	IN
cord-017954-vobslprh	266	79	resistant	resistant	JJ
cord-017954-vobslprh	266	80	C57BL/6	C57BL/6	NNP
cord-017954-vobslprh	266	81	mice	mouse	NNS
cord-017954-vobslprh	266	82	Transfer	transfer	NN
cord-017954-vobslprh	266	83	of	of	IN
cord-017954-vobslprh	266	84	experimental	experimental	JJ
cord-017954-vobslprh	266	85	allergic	allergic	JJ
cord-017954-vobslprh	266	86	neuritis	neuritis	NN
cord-017954-vobslprh	266	87	with	with	IN
cord-017954-vobslprh	266	88	P2-reactive	P2-reactive	NNS
cord-017954-vobslprh	266	89	T	t	NN
cord-017954-vobslprh	266	90	-	-	HYPH
cord-017954-vobslprh	266	91	cell	cell	NN
cord-017954-vobslprh	266	92	lines	line	NNS
cord-017954-vobslprh	266	93	Cell	cell	NN
cord-017954-vobslprh	266	94	adhesion	adhesion	NN
cord-017954-vobslprh	266	95	molecules	molecule	NNS
cord-017954-vobslprh	266	96	of	of	IN
cord-017954-vobslprh	266	97	the	the	DT
cord-017954-vobslprh	266	98	immunoglobulin	immunoglobulin	NN
cord-017954-vobslprh	266	99	supergene	supergene	NN
cord-017954-vobslprh	266	100	family	family	NN
cord-017954-vobslprh	266	101	as	as	IN
cord-017954-vobslprh	266	102	tissue	tissue	NN
cord-017954-vobslprh	266	103	-	-	HYPH
cord-017954-vobslprh	266	104	specific	specific	JJ
cord-017954-vobslprh	266	105	autoantigens	autoantigen	NNS
cord-017954-vobslprh	266	106	:	:	:
cord-017954-vobslprh	266	107	induction	induction	NN
cord-017954-vobslprh	266	108	of	of	IN
cord-017954-vobslprh	266	109	experimental	experimental	JJ
cord-017954-vobslprh	266	110	allergic	allergic	JJ
cord-017954-vobslprh	266	111	neuritis	neuritis	NN
cord-017954-vobslprh	266	112	(	(	-LRB-
cord-017954-vobslprh	266	113	EAN	EAN	NNP
cord-017954-vobslprh	266	114	)	)	-RRB-
cord-017954-vobslprh	266	115	by	by	IN
cord-017954-vobslprh	266	116	P0	p0	NN
cord-017954-vobslprh	266	117	protein	protein	NN
cord-017954-vobslprh	266	118	-	-	HYPH
cord-017954-vobslprh	266	119	specific	specific	JJ
cord-017954-vobslprh	266	120	T	T	NNP
cord-017954-vobslprh	266	121	cell	cell	NN
cord-017954-vobslprh	266	122	lines	line	NNS
cord-017954-vobslprh	267	1	Induction	induction	NN
cord-017954-vobslprh	267	2	of	of	IN
cord-017954-vobslprh	267	3	experimental	experimental	JJ
cord-017954-vobslprh	267	4	allergic	allergic	JJ
cord-017954-vobslprh	267	5	neuritis	neuritis	NN
cord-017954-vobslprh	267	6	in	in	IN
cord-017954-vobslprh	267	7	the	the	DT
cord-017954-vobslprh	267	8	BN	BN	NNP
cord-017954-vobslprh	267	9	rat	rat	NN
cord-017954-vobslprh	267	10	:	:	:
cord-017954-vobslprh	267	11	P2	p2	NN
cord-017954-vobslprh	267	12	protein	protein	NN
cord-017954-vobslprh	267	13	-	-	HYPH
cord-017954-vobslprh	267	14	specific	specific	JJ
cord-017954-vobslprh	267	15	T	t	NN
cord-017954-vobslprh	267	16	cells	cell	NNS
cord-017954-vobslprh	267	17	overcome	overcome	VBP
cord-017954-vobslprh	267	18	resistance	resistance	NN
cord-017954-vobslprh	267	19	to	to	IN
cord-017954-vobslprh	267	20	actively	actively	RB
cord-017954-vobslprh	267	21	induced	induce	VBN
cord-017954-vobslprh	267	22	disease	disease	NN
cord-017954-vobslprh	267	23	Effects	effect	NNS
cord-017954-vobslprh	267	24	of	of	IN
cord-017954-vobslprh	267	25	gangliosides	ganglioside	NNS
cord-017954-vobslprh	267	26	on	on	IN
cord-017954-vobslprh	267	27	the	the	DT
cord-017954-vobslprh	267	28	expression	expression	NN
cord-017954-vobslprh	267	29	of	of	IN
cord-017954-vobslprh	267	30	autoimmune	autoimmune	JJ
cord-017954-vobslprh	267	31	demyelination	demyelination	NN
cord-017954-vobslprh	267	32	in	in	IN
cord-017954-vobslprh	267	33	the	the	DT
cord-017954-vobslprh	267	34	peripheral	peripheral	JJ
cord-017954-vobslprh	267	35	nervous	nervous	JJ
cord-017954-vobslprh	267	36	system	system	NN
cord-017954-vobslprh	267	37	Experimental	experimental	JJ
cord-017954-vobslprh	267	38	sensory	sensory	JJ
cord-017954-vobslprh	267	39	neuropathy	neuropathy	NN
cord-017954-vobslprh	267	40	induced	induce	VBN
cord-017954-vobslprh	267	41	by	by	IN
cord-017954-vobslprh	267	42	sensitization	sensitization	NN
cord-017954-vobslprh	267	43	with	with	IN
cord-017954-vobslprh	267	44	ganglioside	ganglioside	NN
cord-017954-vobslprh	267	45	GD1b	GD1b	NNP
cord-017954-vobslprh	267	46	Experimental	Experimental	NNP
cord-017954-vobslprh	268	1	Campylobacter	Campylobacter	NNP
cord-017954-vobslprh	268	2	jejuni	jejuni	NNP
cord-017954-vobslprh	268	3	infection	infection	NN
cord-017954-vobslprh	268	4	in	in	IN
cord-017954-vobslprh	268	5	the	the	DT
cord-017954-vobslprh	268	6	chicken	chicken	NN
cord-017954-vobslprh	268	7	:	:	:
cord-017954-vobslprh	268	8	an	an	DT
cord-017954-vobslprh	268	9	animal	animal	NN
cord-017954-vobslprh	268	10	model	model	NN
cord-017954-vobslprh	268	11	of	of	IN
cord-017954-vobslprh	268	12	axonal	axonal	JJ
cord-017954-vobslprh	268	13	Guillain	Guillain	NNP
cord-017954-vobslprh	268	14	-	-	HYPH
cord-017954-vobslprh	268	15	Barre	Barre	NNP
cord-017954-vobslprh	268	16	'	'	POS
cord-017954-vobslprh	268	17	syndrome	syndrome	NN
cord-017954-vobslprh	268	18	Myasthenia	myasthenia	NN
cord-017954-vobslprh	268	19	gravis	gravis	NN
cord-017954-vobslprh	268	20	:	:	:
cord-017954-vobslprh	268	21	past	past	NN
cord-017954-vobslprh	268	22	,	,	,
cord-017954-vobslprh	268	23	present	present	JJ
cord-017954-vobslprh	268	24	,	,	,
cord-017954-vobslprh	268	25	and	and	CC
cord-017954-vobslprh	268	26	future	future	JJ
cord-017954-vobslprh	268	27	Autoimmune	autoimmune	JJ
cord-017954-vobslprh	268	28	channelopathies	channelopathie	NNS
cord-017954-vobslprh	268	29	and	and	CC
cord-017954-vobslprh	268	30	related	relate	VBN
cord-017954-vobslprh	268	31	neurological	neurological	JJ
cord-017954-vobslprh	268	32	disorders	disorder	NNS
cord-017954-vobslprh	268	33	Thymus	thymus	NN
cord-017954-vobslprh	268	34	and	and	CC
cord-017954-vobslprh	268	35	myasthenia	myasthenia	NN
cord-017954-vobslprh	268	36	gravis	gravis	NN
cord-017954-vobslprh	268	37	:	:	:
cord-017954-vobslprh	269	1	antigen	antigen	NN
cord-017954-vobslprh	269	2	processing	processing	NN
cord-017954-vobslprh	269	3	in	in	IN
cord-017954-vobslprh	269	4	the	the	DT
cord-017954-vobslprh	269	5	human	human	JJ
cord-017954-vobslprh	269	6	thymus	thymus	NN
cord-017954-vobslprh	269	7	and	and	CC
cord-017954-vobslprh	269	8	the	the	DT
cord-017954-vobslprh	269	9	consequences	consequence	NNS
cord-017954-vobslprh	269	10	for	for	IN
cord-017954-vobslprh	269	11	the	the	DT
cord-017954-vobslprh	269	12	generation	generation	NN
cord-017954-vobslprh	269	13	of	of	IN
cord-017954-vobslprh	269	14	autoreactive	autoreactive	JJ
cord-017954-vobslprh	269	15	T	t	NN
cord-017954-vobslprh	269	16	cells	cell	NNS
cord-017954-vobslprh	269	17	Autoimmune	autoimmune	JJ
cord-017954-vobslprh	269	18	response	response	NN
cord-017954-vobslprh	269	19	to	to	IN
cord-017954-vobslprh	269	20	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	269	21	receptor	receptor	NN
cord-017954-vobslprh	269	22	Experimental	experimental	JJ
cord-017954-vobslprh	269	23	myasthenia	myasthenia	NN
cord-017954-vobslprh	269	24	in	in	IN
cord-017954-vobslprh	269	25	rabbits	rabbit	NNS
cord-017954-vobslprh	269	26	:	:	:
cord-017954-vobslprh	269	27	immunological	immunological	JJ
cord-017954-vobslprh	269	28	,	,	,
cord-017954-vobslprh	269	29	electrophysiological	electrophysiological	JJ
cord-017954-vobslprh	269	30	and	and	CC
cord-017954-vobslprh	269	31	morphological	morphological	JJ
cord-017954-vobslprh	269	32	aspects	aspect	NNS
cord-017954-vobslprh	269	33	Experimental	experimental	JJ
cord-017954-vobslprh	269	34	autoimmune	autoimmune	JJ
cord-017954-vobslprh	269	35	myasthenia	myasthenia	NN
cord-017954-vobslprh	269	36	:	:	:
cord-017954-vobslprh	270	1	a	a	DT
cord-017954-vobslprh	270	2	model	model	NN
cord-017954-vobslprh	270	3	of	of	IN
cord-017954-vobslprh	270	4	myasthenia	myasthenia	NN
cord-017954-vobslprh	270	5	gravis	gravis	NN
cord-017954-vobslprh	270	6	in	in	IN
cord-017954-vobslprh	270	7	rats	rat	NNS
cord-017954-vobslprh	270	8	and	and	CC
cord-017954-vobslprh	270	9	guinea	guinea	NN
cord-017954-vobslprh	270	10	pigs	pig	NNS
cord-017954-vobslprh	270	11	Strain	strain	VBP
cord-017954-vobslprh	270	12	differences	difference	NNS
cord-017954-vobslprh	270	13	in	in	IN
cord-017954-vobslprh	270	14	the	the	DT
cord-017954-vobslprh	270	15	autoimmune	autoimmune	JJ
cord-017954-vobslprh	270	16	response	response	NN
cord-017954-vobslprh	270	17	of	of	IN
cord-017954-vobslprh	270	18	mice	mouse	NNS
cord-017954-vobslprh	270	19	to	to	IN
cord-017954-vobslprh	270	20	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	270	21	receptors	receptor	NNS
cord-017954-vobslprh	270	22	Genetic	genetic	JJ
cord-017954-vobslprh	270	23	control	control	NN
cord-017954-vobslprh	270	24	of	of	IN
cord-017954-vobslprh	270	25	experimental	experimental	JJ
cord-017954-vobslprh	270	26	autoimmune	autoimmune	JJ
cord-017954-vobslprh	270	27	myasthenia	myasthenia	NN
cord-017954-vobslprh	270	28	gravis	gravis	NN
cord-017954-vobslprh	270	29	in	in	IN
cord-017954-vobslprh	270	30	mice	mouse	NNS
cord-017954-vobslprh	271	1	Immunological	immunological	JJ
cord-017954-vobslprh	271	2	studies	study	NNS
cord-017954-vobslprh	271	3	of	of	IN
cord-017954-vobslprh	271	4	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	271	5	receptors	receptor	NNS
cord-017954-vobslprh	271	6	Experimental	experimental	JJ
cord-017954-vobslprh	271	7	autoimmune	autoimmune	JJ
cord-017954-vobslprh	271	8	myasthenia	myasthenia	NN
cord-017954-vobslprh	271	9	induced	induce	VBN
cord-017954-vobslprh	271	10	in	in	IN
cord-017954-vobslprh	271	11	monkeys	monkey	NNS
cord-017954-vobslprh	271	12	by	by	IN
cord-017954-vobslprh	271	13	purified	purify	VBN
cord-017954-vobslprh	271	14	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	271	15	receptor	receptor	NN
cord-017954-vobslprh	271	16	Myasthenia	Myasthenia	NNP
cord-017954-vobslprh	271	17	in	in	IN
cord-017954-vobslprh	271	18	frogs	frog	NNS
cord-017954-vobslprh	271	19	immunized	immunize	VBN
cord-017954-vobslprh	271	20	against	against	IN
cord-017954-vobslprh	271	21	cholinergic	cholinergic	JJ
cord-017954-vobslprh	271	22	receptor	receptor	NN
cord-017954-vobslprh	271	23	protein	protein	NN
cord-017954-vobslprh	271	24	Immunogenetics	immunogenetic	NNS
cord-017954-vobslprh	271	25	of	of	IN
cord-017954-vobslprh	271	26	experimental	experimental	JJ
cord-017954-vobslprh	271	27	autoimmune	autoimmune	JJ
cord-017954-vobslprh	271	28	myasthenia	myasthenia	NN
cord-017954-vobslprh	271	29	gravis	gravis	NNP
cord-017954-vobslprh	271	30	A	a	DT
cord-017954-vobslprh	271	31	molecular	molecular	JJ
cord-017954-vobslprh	271	32	basis	basis	NN
cord-017954-vobslprh	271	33	for	for	IN
cord-017954-vobslprh	271	34	MHC	MHC	NNP
cord-017954-vobslprh	271	35	class	class	NN
cord-017954-vobslprh	271	36	Il	Il	NNP
cord-017954-vobslprh	271	37	-	-	HYPH
cord-017954-vobslprh	271	38	associated	associate	VBN
cord-017954-vobslprh	271	39	autoimmunity	autoimmunity	IN
cord-017954-vobslprh	271	40	Autoimmune	autoimmune	JJ
cord-017954-vobslprh	271	41	human	human	JJ
cord-017954-vobslprh	271	42	T	t	NN
cord-017954-vobslprh	271	43	lymphocytes	lymphocyte	NNS
cord-017954-vobslprh	271	44	specific	specific	JJ
cord-017954-vobslprh	271	45	for	for	IN
cord-017954-vobslprh	271	46	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	271	47	receptor	receptor	NN
cord-017954-vobslprh	271	48	Immuno	immuno	JJ
cord-017954-vobslprh	271	49	-	-	HYPH
cord-017954-vobslprh	271	50	therapy	therapy	NN
cord-017954-vobslprh	271	51	for	for	IN
cord-017954-vobslprh	271	52	myasthenia	myasthenia	NN
cord-017954-vobslprh	271	53	gravis	gravis	NNP
cord-017954-vobslprh	271	54	:	:	:
cord-017954-vobslprh	271	55	a	a	DT
cord-017954-vobslprh	271	56	murine	murine	JJ
cord-017954-vobslprh	271	57	model	model	NN
cord-017954-vobslprh	271	58	Animal	animal	JJ
cord-017954-vobslprh	271	59	models	model	NNS
cord-017954-vobslprh	271	60	of	of	IN
cord-017954-vobslprh	271	61	myasthenia	myasthenia	NN
cord-017954-vobslprh	271	62	gravis	gravis	NN
cord-017954-vobslprh	272	1	In	in	IN
cord-017954-vobslprh	272	2	vivo	vivo	NN
cord-017954-vobslprh	272	3	therapy	therapy	NN
cord-017954-vobslprh	272	4	with	with	IN
cord-017954-vobslprh	272	5	monoclonal	monoclonal	JJ
cord-017954-vobslprh	272	6	anti	anti	NNP
cord-017954-vobslprh	272	7	-	-	JJ
cord-017954-vobslprh	272	8	IA	IA	NNP
cord-017954-vobslprh	272	9	antibody	antibody	NN
cord-017954-vobslprh	272	10	suppresses	suppress	VBZ
cord-017954-vobslprh	272	11	immune	immune	JJ
cord-017954-vobslprh	272	12	response	response	NN
cord-017954-vobslprh	272	13	to	to	IN
cord-017954-vobslprh	272	14	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	272	15	receptor	receptor	NN
cord-017954-vobslprh	272	16	Daunomycin	Daunomycin	NNP
cord-017954-vobslprh	272	17	treatment	treatment	NN
cord-017954-vobslprh	272	18	prevents	prevent	VBZ
cord-017954-vobslprh	272	19	clinical	clinical	JJ
cord-017954-vobslprh	272	20	expression	expression	NN
cord-017954-vobslprh	272	21	of	of	IN
cord-017954-vobslprh	272	22	experimental	experimental	JJ
cord-017954-vobslprh	272	23	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	24	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	25	gravis	gravis	NN
cord-017954-vobslprh	272	26	Oral	oral	JJ
cord-017954-vobslprh	272	27	administration	administration	NN
cord-017954-vobslprh	272	28	of	of	IN
cord-017954-vobslprh	272	29	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	272	30	receptors	receptor	NNS
cord-017954-vobslprh	272	31	:	:	:
cord-017954-vobslprh	272	32	effects	effect	NNS
cord-017954-vobslprh	272	33	on	on	IN
cord-017954-vobslprh	272	34	experimental	experimental	JJ
cord-017954-vobslprh	272	35	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	36	gravis	gravis	NN
cord-017954-vobslprh	272	37	IFN	IFN	NNP
cord-017954-vobslprh	272	38	-	-	HYPH
cord-017954-vobslprh	272	39	α	α	NNP
cord-017954-vobslprh	272	40	treatment	treatment	NN
cord-017954-vobslprh	272	41	suppresses	suppress	VBZ
cord-017954-vobslprh	272	42	the	the	DT
cord-017954-vobslprh	272	43	development	development	NN
cord-017954-vobslprh	272	44	of	of	IN
cord-017954-vobslprh	272	45	experimental	experimental	JJ
cord-017954-vobslprh	272	46	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	47	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	48	gravis	gravis	FW
cord-017954-vobslprh	272	49	Anti	Anti	NNP
cord-017954-vobslprh	272	50	-	-	NNP
cord-017954-vobslprh	272	51	TNF	TNF	NNP
cord-017954-vobslprh	272	52	-	-	HYPH
cord-017954-vobslprh	272	53	alpha	alpha	NN
cord-017954-vobslprh	272	54	antibodies	antibody	NNS
cord-017954-vobslprh	272	55	suppress	suppress	VBP
cord-017954-vobslprh	272	56	the	the	DT
cord-017954-vobslprh	272	57	development	development	NN
cord-017954-vobslprh	272	58	of	of	IN
cord-017954-vobslprh	272	59	experimental	experimental	JJ
cord-017954-vobslprh	272	60	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	61	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	62	gravis	gravis	NNP
cord-017954-vobslprh	272	63	Treatment	Treatment	NNP
cord-017954-vobslprh	272	64	of	of	IN
cord-017954-vobslprh	272	65	experimental	experimental	JJ
cord-017954-vobslprh	272	66	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	67	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	68	gravis	gravis	NN
cord-017954-vobslprh	272	69	with	with	IN
cord-017954-vobslprh	272	70	recombinant	recombinant	JJ
cord-017954-vobslprh	272	71	human	human	JJ
cord-017954-vobslprh	272	72	tumor	tumor	NN
cord-017954-vobslprh	272	73	necrosis	necrosis	NN
cord-017954-vobslprh	272	74	factor	factor	NN
cord-017954-vobslprh	272	75	receptor	receptor	NN
cord-017954-vobslprh	272	76	Fc	Fc	NNP
cord-017954-vobslprh	272	77	protein	protein	NN
cord-017954-vobslprh	272	78	Etanercept	Etanercept	NNP
cord-017954-vobslprh	272	79	treatment	treatment	NN
cord-017954-vobslprh	272	80	in	in	IN
cord-017954-vobslprh	272	81	corticosteroid	corticosteroid	JJ
cord-017954-vobslprh	272	82	dependent	dependent	JJ
cord-017954-vobslprh	272	83	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	84	gravis	gravis	NN
cord-017954-vobslprh	272	85	Ultrastructural	Ultrastructural	NNP
cord-017954-vobslprh	272	86	localization	localization	NN
cord-017954-vobslprh	272	87	of	of	IN
cord-017954-vobslprh	272	88	immune	immune	JJ
cord-017954-vobslprh	272	89	complexes	complex	NNS
cord-017954-vobslprh	272	90	(	(	-LRB-
cord-017954-vobslprh	272	91	IgG	IgG	NNP
cord-017954-vobslprh	272	92	and	and	CC
cord-017954-vobslprh	272	93	C3	C3	NNP
cord-017954-vobslprh	272	94	)	)	-RRB-
cord-017954-vobslprh	272	95	at	at	IN
cord-017954-vobslprh	272	96	the	the	DT
cord-017954-vobslprh	272	97	end	end	NN
cord-017954-vobslprh	272	98	-	-	HYPH
cord-017954-vobslprh	272	99	plate	plate	NN
cord-017954-vobslprh	272	100	in	in	IN
cord-017954-vobslprh	272	101	experimental	experimental	JJ
cord-017954-vobslprh	272	102	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	103	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	104	gravis	gravis	NN
cord-017954-vobslprh	272	105	Ultrastructural	Ultrastructural	NNP
cord-017954-vobslprh	272	106	localization	localization	NN
cord-017954-vobslprh	272	107	of	of	IN
cord-017954-vobslprh	272	108	the	the	DT
cord-017954-vobslprh	272	109	terminal	terminal	JJ
cord-017954-vobslprh	272	110	and	and	CC
cord-017954-vobslprh	272	111	lytic	lytic	JJ
cord-017954-vobslprh	272	112	ninth	ninth	JJ
cord-017954-vobslprh	272	113	complement	complement	NN
cord-017954-vobslprh	272	114	component	component	NN
cord-017954-vobslprh	272	115	(	(	-LRB-
cord-017954-vobslprh	272	116	C9	C9	NNP
cord-017954-vobslprh	272	117	)	)	-RRB-
cord-017954-vobslprh	272	118	at	at	IN
cord-017954-vobslprh	272	119	the	the	DT
cord-017954-vobslprh	272	120	motor	motor	NN
cord-017954-vobslprh	272	121	end	end	NN
cord-017954-vobslprh	272	122	-	-	HYPH
cord-017954-vobslprh	272	123	plate	plate	NN
cord-017954-vobslprh	272	124	in	in	IN
cord-017954-vobslprh	272	125	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	126	gravis	gravis	FW
cord-017954-vobslprh	272	127	Myasthenia	Myasthenia	NNP
cord-017954-vobslprh	272	128	gravis	gravis	NN
cord-017954-vobslprh	272	129	:	:	:
cord-017954-vobslprh	272	130	quantitative	quantitative	JJ
cord-017954-vobslprh	272	131	immunocytochemical	immunocytochemical	JJ
cord-017954-vobslprh	272	132	analysis	analysis	NN
cord-017954-vobslprh	272	133	of	of	IN
cord-017954-vobslprh	272	134	inflammatory	inflammatory	JJ
cord-017954-vobslprh	272	135	cells	cell	NNS
cord-017954-vobslprh	272	136	and	and	CC
cord-017954-vobslprh	272	137	detection	detection	NN
cord-017954-vobslprh	272	138	of	of	IN
cord-017954-vobslprh	272	139	complement	complement	JJ
cord-017954-vobslprh	272	140	membrane	membrane	NN
cord-017954-vobslprh	272	141	attack	attack	NN
cord-017954-vobslprh	272	142	complex	complex	JJ
cord-017954-vobslprh	272	143	at	at	IN
cord-017954-vobslprh	272	144	the	the	DT
cord-017954-vobslprh	272	145	end	end	NN
cord-017954-vobslprh	272	146	-	-	HYPH
cord-017954-vobslprh	272	147	plate	plate	NN
cord-017954-vobslprh	272	148	in	in	IN
cord-017954-vobslprh	272	149	30	30	CD
cord-017954-vobslprh	272	150	patients	patient	NNS
cord-017954-vobslprh	272	151	Inhibition	inhibition	NN
cord-017954-vobslprh	272	152	of	of	IN
cord-017954-vobslprh	272	153	acute	acute	JJ
cord-017954-vobslprh	272	154	passive	passive	JJ
cord-017954-vobslprh	272	155	transfer	transfer	VB
cord-017954-vobslprh	272	156	experimental	experimental	JJ
cord-017954-vobslprh	272	157	autoimmune	autoimmune	JJ
cord-017954-vobslprh	272	158	myasthenia	myasthenia	NN
cord-017954-vobslprh	272	159	gravis	gravis	NN
cord-017954-vobslprh	272	160	with	with	IN
cord-017954-vobslprh	272	161	Fab	fab	JJ
cord-017954-vobslprh	272	162	antibody	antibody	NN
cord-017954-vobslprh	272	163	to	to	TO
cord-017954-vobslprh	272	164	complement	complement	VB
cord-017954-vobslprh	272	165	C6	C6	NNP
cord-017954-vobslprh	272	166	Novel	Novel	NNP
cord-017954-vobslprh	272	167	complement	complement	NN
cord-017954-vobslprh	272	168	inhibitor	inhibitor	NN
cord-017954-vobslprh	272	169	limits	limit	VBZ
cord-017954-vobslprh	272	170	severity	severity	NN
cord-017954-vobslprh	272	171	of	of	IN
cord-017954-vobslprh	272	172	experimentally	experimentally	RB
cord-017954-vobslprh	272	173	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	1	gravis	gravis	NNP
cord-017954-vobslprh	273	2	Anti	Anti	NNP
cord-017954-vobslprh	273	3	-	-	NNP
cord-017954-vobslprh	273	4	C5	C5	NNP
cord-017954-vobslprh	273	5	antibody	antibody	NN
cord-017954-vobslprh	273	6	treatment	treatment	NN
cord-017954-vobslprh	273	7	ameliorates	ameliorate	VBZ
cord-017954-vobslprh	273	8	weakness	weakness	NN
cord-017954-vobslprh	273	9	in	in	IN
cord-017954-vobslprh	273	10	experimentally	experimentally	RB
cord-017954-vobslprh	273	11	acquired	acquire	VBN
cord-017954-vobslprh	273	12	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	13	gravis	gravis	NN
cord-017954-vobslprh	273	14	Immune	Immune	NNP
cord-017954-vobslprh	273	15	complexes	complex	NNS
cord-017954-vobslprh	273	16	(	(	-LRB-
cord-017954-vobslprh	273	17	IgG	IgG	NNP
cord-017954-vobslprh	273	18	and	and	CC
cord-017954-vobslprh	273	19	C3	C3	NNP
cord-017954-vobslprh	273	20	)	)	-RRB-
cord-017954-vobslprh	273	21	at	at	IN
cord-017954-vobslprh	273	22	the	the	DT
cord-017954-vobslprh	273	23	motor	motor	NN
cord-017954-vobslprh	273	24	end	end	NN
cord-017954-vobslprh	273	25	-	-	HYPH
cord-017954-vobslprh	273	26	plate	plate	NN
cord-017954-vobslprh	273	27	in	in	IN
cord-017954-vobslprh	273	28	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	29	gravis	gravis	NN
cord-017954-vobslprh	273	30	:	:	:
cord-017954-vobslprh	273	31	ultrastructural	ultrastructural	JJ
cord-017954-vobslprh	273	32	and	and	CC
cord-017954-vobslprh	273	33	light	light	JJ
cord-017954-vobslprh	273	34	microscopic	microscopic	JJ
cord-017954-vobslprh	273	35	localization	localization	NN
cord-017954-vobslprh	273	36	and	and	CC
cord-017954-vobslprh	273	37	electrophysiologic	electrophysiologic	JJ
cord-017954-vobslprh	273	38	correlations	correlation	NNS
cord-017954-vobslprh	273	39	Passively	passively	RB
cord-017954-vobslprh	273	40	transferred	transfer	VBD
cord-017954-vobslprh	273	41	experimental	experimental	JJ
cord-017954-vobslprh	273	42	autoimmune	autoimmune	JJ
cord-017954-vobslprh	273	43	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	44	gravis	gravis	FW
cord-017954-vobslprh	273	45	Myasthenia	Myasthenia	NNP
cord-017954-vobslprh	273	46	gravis	gravis	NN
cord-017954-vobslprh	273	47	:	:	:
cord-017954-vobslprh	273	48	passive	passive	JJ
cord-017954-vobslprh	273	49	transfer	transfer	NN
cord-017954-vobslprh	273	50	from	from	IN
cord-017954-vobslprh	273	51	man	man	NN
cord-017954-vobslprh	273	52	to	to	TO
cord-017954-vobslprh	273	53	mouse	mouse	VB
cord-017954-vobslprh	273	54	Experimental	experimental	JJ
cord-017954-vobslprh	273	55	autoimmune	autoimmune	JJ
cord-017954-vobslprh	273	56	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	57	:	:	:
cord-017954-vobslprh	273	58	cellular	cellular	JJ
cord-017954-vobslprh	273	59	and	and	CC
cord-017954-vobslprh	273	60	humoral	humoral	JJ
cord-017954-vobslprh	273	61	immune	immune	JJ
cord-017954-vobslprh	273	62	responses	response	NNS
cord-017954-vobslprh	273	63	Auto	auto	NN
cord-017954-vobslprh	273	64	-	-	HYPH
cord-017954-vobslprh	273	65	antibodies	antibody	NNS
cord-017954-vobslprh	273	66	to	to	IN
cord-017954-vobslprh	273	67	the	the	DT
cord-017954-vobslprh	273	68	receptor	receptor	NN
cord-017954-vobslprh	273	69	tyrosine	tyrosine	NN
cord-017954-vobslprh	273	70	kinase	kinase	NN
cord-017954-vobslprh	273	71	MuSK	MuSK	NNP
cord-017954-vobslprh	273	72	in	in	IN
cord-017954-vobslprh	273	73	patients	patient	NNS
cord-017954-vobslprh	273	74	with	with	IN
cord-017954-vobslprh	273	75	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	76	gravis	gravis	NN
cord-017954-vobslprh	273	77	without	without	IN
cord-017954-vobslprh	273	78	acetylcholine	acetylcholine	NN
cord-017954-vobslprh	273	79	receptor	receptor	NN
cord-017954-vobslprh	273	80	antibodies	antibody	NNS
cord-017954-vobslprh	273	81	Induction	Induction	NNP
cord-017954-vobslprh	273	82	of	of	IN
cord-017954-vobslprh	273	83	myasthenia	myasthenia	NN
cord-017954-vobslprh	273	84	by	by	IN
cord-017954-vobslprh	273	85	immunization	immunization	NN
cord-017954-vobslprh	273	86	against	against	IN
cord-017954-vobslprh	273	87	muscle	muscle	NN
cord-017954-vobslprh	273	88	-	-	HYPH
cord-017954-vobslprh	273	89	specific	specific	JJ
cord-017954-vobslprh	273	90	kinase	kinase	NN
cord-017954-vobslprh	273	91	Myasthenia	myasthenia	NN
cord-017954-vobslprh	273	92	gravis	gravis	NN
cord-017954-vobslprh	273	93	experimentally	experimentally	RB
cord-017954-vobslprh	273	94	induced	induce	VBN
cord-017954-vobslprh	273	95	with	with	IN
cord-017954-vobslprh	273	96	muscle	muscle	NN
cord-017954-vobslprh	273	97	-	-	HYPH
cord-017954-vobslprh	273	98	specific	specific	JJ
cord-017954-vobslprh	273	99	kinase	kinase	NN