id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353298-vr5hnzp8	nan	In vitro analysis of the oligodendrocyte lineage in mice during demyelination and remyelination	1990-09-01		.txt	text/plain	6929	326	45	Cultures from demyelinated tissue differed in several ways from those of age-matched controls: first, the total number of O-2A lineage cells was strikingly increased; second, the O-2A population consisted of a higher proportion of O4-positive astrocytes and cells of mixed oligodendrocyte-astrocyte phenotype; and third, all the cell types within the O-2A lineage showed enhanced proliferation. Cultures from demyelinated tissue differed in several ways from those of agematched controls: first, the total number of O-2A lin-cage cells was strikingly increased; second, the O-2A population consisted of a higher proportion of 04positive astrocytes and cells of mixed oligodendrocyteastrocyte phenotype; and third, all the cell types within the O-2A lineage showed enhanced proliferation. Since PDGF, IGF-I, and bFGF can each induce proliferation of neonatal O-2A progenitor cells in the developing rat CNS (reviewed in Dubois-Dalcq and Armstrong, 1990), we assayed the mitogenic effect of these growth factors in our cultures of adult mouse spinal cord (see protocol outlined in Fig. 1 C) .	./cache/cord-353298-vr5hnzp8.txt	./txt/cord-353298-vr5hnzp8.txt