id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351398-ftkrd1tj	Stohlman, Stephen A.	Viral Induced Demyelination	2006-04-05		.txt	text/plain	8223	374	36	This suggests that demyelination induced by viral infections can result from: 1) a direct viral infection of oligodendroglia resulting in cell death with degeneration of myelin and its subsequent removal; 2) a persistent viral infection, in the presence or absence of infectious virus, resulting in the loss of normal cellular homeostasis and subsequent oligodendroglial death; 3) a vigorous virus‐specific inflammatory response wherein the virus replicates in a cell type other than oligodendroglia, but cytokines and other immune mediators directly damage the oligodendroglia or the myelin sheath; or 4) infection initiates activation of an immune response specific for either oligodendroglia or myelin components. Although the relevance of these neuroantigen specific T cells to the progression of chronic demyelination is still not clear, the data clearly demonstrate activation of immunity to host antigens during inflammation induced by a persistent viral infection.	./cache/cord-351398-ftkrd1tj.txt	./txt/cord-351398-ftkrd1tj.txt