id author title date pages extension mime words sentences flesch summary cache txt cord-309109-c5hajb6k Matthews, A. E. Murine hepatitis virus—A model for virus-induced CNS demyelination 2002 .txt text/plain 6898 335 50 Although activated , MHV-speci c, CD8 C T cells transferred to infected mice can control viral replication, they are not suf cient to clear infectious virus from oligodendrocytes (Stohlman et al, 1998b) . Clearance of an MHV strain that primarily infects neurons is delayed in the absence of IFN-gamma, suggesting that it may affect viral control in other cell types as well without being absolutely required for clearance (Lane et al, 1997) . The contribution of humoral immunity to viral clearance and persistent infection in the CNS has been investigated using mice de cient in secreted antibodies or B cells Bergmann et al, 2001; Matthews et al, 2001) . These data suggest that T cells play a role in controlling viral titers, even before 5 d.p.i. Beta2-microglobulinde cient mice, which lack CD8 C T cells, have delayed clearance of virus from the liver . ./cache/cord-309109-c5hajb6k.txt ./txt/cord-309109-c5hajb6k.txt