id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299967-90aknp7c	Terry, Rachael L	Inflammatory monocytes and the pathogenesis of viral encephalitis	2012-12-17		.txt	text/plain	6111	327	35	Monocytes are a heterogeneous population of bone marrow-derived cells that are recruited to sites of infection and inflammation in many models of human diseases, including those of the central nervous system (CNS). Ly6C(hi)/CCR2(hi) inflammatory monocytes have been identified as the circulating precursors of brain macrophages, dendritic cells and arguably microglia in experimental autoimmune encephalomyelitis; Alzheimer's disease; stroke; and more recently in CNS infection caused by Herpes simplex virus, murine hepatitis virus, Theiler's murine encephalomyelitis virus, Japanese encephalitis virus and West Nile virus. Competitive and non-competitive glutamate receptor antagonists promote survival during neurovirulent Sindbis virus encephalitis [35, 36] and improved outcomes during coronavirus encephalitis [37] ↑ neuronal damage/ death ↑ production of NO/ ROS Reviewed in [38] BBB blood brain barrier; CNS central nervous system; HSV herpes simplex virus; MDP macrophage/dendritic cell precursor; MHV murine hepatitis virus; MMP matrix metalloproteinases; NO nitric oxide; NOS2 nitric oxide synthase-2; ROS reactive oxygen species; TMEV Theiler's murine encephalomyelitis virus; WNV West Nile virus.	./cache/cord-299967-90aknp7c.txt	./txt/cord-299967-90aknp7c.txt