id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297448-aiorjsyh	Atkinson, Jeffrey R.	Dynamics of Virus-Specific Memory B Cells and Plasmablasts following Viral Infection of the Central Nervous System	2019-01-04		.txt	text/plain	7702	393	52	During infection with a gliatropic mouse hepatitis virus (MHV) derived from the JHM strain (JHMv2.2-1), IgDpositive (IgD ϩ ) (naive/transitional) B cells prevail early, but they decrease coincident with increasing proportions of CD138 ϩ antibody (Ab)-secreting cells (ASC) and CD138 Ϫ IgG ϩ isotype-switched memory B cells (Bmem) as germinal centers (GCs) are formed in draining lymph nodes (1, 2) . To better characterize the proportions of virus-specific Bmem and ASC accumulating in the CLN and the CNS following viral encephalomyelitis, we took advantage of mice expressing tamoxifen-inducible Cre recombinase (Cre-ERT2) under the Aicda promoter crossed with Rosa26-loxP-tdTomato reporter mice to obtain progeny in which AIDexpressing cells can be identified by fluorescence following tamoxifen administration (4, 27) . Comparison of total numbers of tdTomato ϩ cells and their compositions of ASC and Bmem in brains and spinal cords over time following infection revealed overall similar kinetics of virus-specific B cell accumulation (Fig. 5B) .	./cache/cord-297448-aiorjsyh.txt	./txt/cord-297448-aiorjsyh.txt