id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-008523-avkgldnp	Perlman, Stanley	Selection of and evasion from cytotoxic T cell responses in the central nervous system	2004-01-07		.txt	text/plain	8866	401	44	In mice that were transgenic for a T cell receptor (TCR) specific for lymphocytic choriomeningitis virus (LCMV), infection with LCMV resulted in the rapid appearance of virus mutated in the target CTL epitope. In these mice, CTLs recognizing multiple epitopes are detected, suggesting that an immune response directed against several epitopes precluded the selection of CTL escape mutants, at least in settings in which virus clearance was relatively efficient. One of the best examples of a pathological setting in which CTL escape mutants contribute to virus persistence and the development of disease is that of mice infected with the neurotropic coronavirus, mouse hepatitis virus--strain JHM (MHV-JHM). These results suggest that CTL escape mutants are critical in virus persistence and in the development of clinical disease in mice infected with MHV-JHM. The selection of CTL escape mutants in the CNS of MHV-infected mice demonstrates that MHV infection of a cell expressing MHC class I antigen is a critical part of the pathogenic process.	./cache/cord-008523-avkgldnp.txt	./txt/cord-008523-avkgldnp.txt