id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005734-14ba78cz	Bennett, Jami L.	CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler’s murine encephalomyelitis virus-induced demyelinating disease	2003		.txt	text/plain	7588	361	45	title: CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler's murine encephalomyelitis virus-induced demyelinating disease To test the hypothesis that the presence of CCL2 in the CNS could regulate an immune-mediated, macrophage-dependent demyelinating disease, we infected either control, JE32, or JE95 (described previously; Huang et al [2002] ) transgenic mice with TMEV and assessed the animals for resulting clinical paralysis. However, it could be possible that the presence of any virus in the CNS of CCL2-transgenic mice would be a sufficient stimulus to activate the accumulated macrophage pool, initiating inflammation and development of demyelinating disease. Further, the mCMV studies demonstrate that the accelerated disease observed in CCL2-transgenic mice is specific to TMEV infection and not due to a nonspecific activation of localized monocytes/macrophages by any virus introduced into the CNS.	./cache/cord-005734-14ba78cz.txt	./txt/cord-005734-14ba78cz.txt