id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005393-rhji4io9	Popko, Brian	The effects of interferon-γ on the central nervous system	1997		.txt	text/plain	7969	418	42	A large portion of this article is devoted to the substantial circumstantial and experimental evidence that suggests that IFN-γ plays an important role in the pathogenesis of the demyelinating disorder multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). For example, the genes encoding the gaunylate binding protein and the IgG Fc receptor are induced in this way: Other genes that are stimulated by IFN-~/, such as the class I and class II molecules of the major histocompatibility complex (MHC), require a longer period (several hours) before transcriptional induction is detected. Many of the pathological events Observed in MS and EAE, such as increased MHC expression, macrophage activation, increased expression of leukocyte adhesion molecules on blood-brain barrier endothelial cells (Olsson, 1992) , and reactive gliosis (Balasingam et al., 1994) , are consistent with the known effects of IFN-~,. (1984) demonstrated a dramatic increase in the expression of the MHC class I glycoprotein in astrocytes, neurons, oligodendrocytes and microglia following the delivery of IFN-y to the CNS of 2-dold mice.	./cache/cord-005393-rhji4io9.txt	./txt/cord-005393-rhji4io9.txt