id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001332-dp6vzgef	Hosking, Martin P.	ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease	2014-06-17		.txt	text/plain	2736	152	31	Intracranial infection of the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis, accompanied by viral replication in glial cells and robust infiltration of virus-specific T cells that contribute to host defense through cytokine secretion and cytolytic activity. Moreover, PMNs have been shown to enhance central nervous system (CNS) inflammation by disrupting blood brain barrier (BBB) integrity in animal models of spinal cord injury (SCI; Tonai et al., 2001; Gorio et al., 2007) , autoimmune demyelination (Carlson et al., 2008) , and JHMV-induced encephalomyelitis (Zhou et al., 2003) , while blocking or silencing of CXCR2 signaling mutes inflammation and tissue damage in mouse models in which PMN infiltration is critical to disease initiation (Kielian et al., 2001; Belperio et al., 2005; Londhe et al., 2005a,b; Strieter et al., 2005; Gorio et al., 2007; Wareing et al., 2007; Carlson et al., 2008) .	./cache/cord-001332-dp6vzgef.txt	./txt/cord-001332-dp6vzgef.txt