id sid tid token lemma pos cord-015365-iqdi99pd 1 1 key key JJ cord-015365-iqdi99pd 1 2 : : : cord-015365-iqdi99pd 1 3 cord-015365-iqdi99pd cord-015365-iqdi99pd JJ cord-015365-iqdi99pd 1 4 authors author NNS cord-015365-iqdi99pd 1 5 : : : cord-015365-iqdi99pd 2 1 nan nan NNP cord-015365-iqdi99pd 2 2 title title NN cord-015365-iqdi99pd 2 3 : : : cord-015365-iqdi99pd 2 4 25th 25th JJ cord-015365-iqdi99pd 2 5 Annual Annual NNP cord-015365-iqdi99pd 2 6 Meeting Meeting NNP cord-015365-iqdi99pd 2 7 of of IN cord-015365-iqdi99pd 2 8 the the DT cord-015365-iqdi99pd 2 9 Austrian Austrian NNP cord-015365-iqdi99pd 2 10 Society Society NNP cord-015365-iqdi99pd 2 11 of of IN cord-015365-iqdi99pd 2 12 Transplantation Transplantation NNP cord-015365-iqdi99pd 2 13 , , , cord-015365-iqdi99pd 2 14 Transfusion Transfusion NNP cord-015365-iqdi99pd 2 15 and and CC cord-015365-iqdi99pd 2 16 Genetics Genetics NNP cord-015365-iqdi99pd 2 17 Graz Graz NNP cord-015365-iqdi99pd 2 18 , , , cord-015365-iqdi99pd 2 19 October October NNP cord-015365-iqdi99pd 2 20 19–21 19–21 CD cord-015365-iqdi99pd 2 21 , , , cord-015365-iqdi99pd 2 22 2011 2011 CD cord-015365-iqdi99pd 2 23 date date NN cord-015365-iqdi99pd 2 24 : : : cord-015365-iqdi99pd 3 1 2011 2011 CD cord-015365-iqdi99pd 3 2 journal journal NNP cord-015365-iqdi99pd 3 3 : : : cord-015365-iqdi99pd 4 1 Eur Eur NNP cord-015365-iqdi99pd 4 2 Surg Surg NNP cord-015365-iqdi99pd 4 3 DOI DOI NNP cord-015365-iqdi99pd 5 1 : : : cord-015365-iqdi99pd 5 2 10.1007 10.1007 CD cord-015365-iqdi99pd 5 3 / / SYM cord-015365-iqdi99pd 5 4 s10353 s10353 CD cord-015365-iqdi99pd 5 5 - - HYPH cord-015365-iqdi99pd 5 6 011 011 CD cord-015365-iqdi99pd 5 7 - - HYPH cord-015365-iqdi99pd 5 8 0041-z 0041-z NN cord-015365-iqdi99pd 5 9 sha sha NNP cord-015365-iqdi99pd 5 10 : : : cord-015365-iqdi99pd 6 1 5fcaa5b826f3255958984041b5e25f3549b12ae7 5fcaa5b826f3255958984041b5e25f3549b12ae7 XX cord-015365-iqdi99pd 7 1 doc_id doc_id CD cord-015365-iqdi99pd 7 2 : : : cord-015365-iqdi99pd 8 1 15365 15365 CD cord-015365-iqdi99pd 8 2 cord_uid cord_uid NNS cord-015365-iqdi99pd 8 3 : : : cord-015365-iqdi99pd 8 4 iqdi99pd iqdi99pd XX cord-015365-iqdi99pd 8 5 nan nan NNP cord-015365-iqdi99pd 8 6 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 8 7 . . . cord-015365-iqdi99pd 9 1 Parvovirus Parvovirus NNP cord-015365-iqdi99pd 9 2 B19 B19 NNP cord-015365-iqdi99pd 9 3 ( ( -LRB- cord-015365-iqdi99pd 9 4 PVB19 pvb19 NN cord-015365-iqdi99pd 9 5 ) ) -RRB- cord-015365-iqdi99pd 9 6 als als NNP cord-015365-iqdi99pd 10 1 Ursache Ursache NNP cord-015365-iqdi99pd 10 2 einer einer NNP cord-015365-iqdi99pd 10 3 schweren schweren NNP cord-015365-iqdi99pd 10 4 aplastischen aplastischen NNP cord-015365-iqdi99pd 10 5 Anämie Anämie NNP cord-015365-iqdi99pd 10 6 ( ( -LRB- cord-015365-iqdi99pd 10 7 SAA SAA NNP cord-015365-iqdi99pd 10 8 ) ) -RRB- cord-015365-iqdi99pd 10 9 oder oder NNP cord-015365-iqdi99pd 10 10 eines eines NNP cord-015365-iqdi99pd 11 1 myelodysplastischen myelodysplastischen NNP cord-015365-iqdi99pd 11 2 Syndroms Syndroms NNP cord-015365-iqdi99pd 11 3 ( ( -LRB- cord-015365-iqdi99pd 11 4 MDS MDS NNP cord-015365-iqdi99pd 11 5 ) ) -RRB- cord-015365-iqdi99pd 11 6 ist ist NNP cord-015365-iqdi99pd 11 7 bisher bisher NNP cord-015365-iqdi99pd 11 8 erst erst NNP cord-015365-iqdi99pd 11 9 selten selten NNP cord-015365-iqdi99pd 11 10 beschrieben beschrieben NNP cord-015365-iqdi99pd 11 11 . . . cord-015365-iqdi99pd 12 1 Es Es NNP cord-015365-iqdi99pd 12 2 existieren existieren NNP cord-015365-iqdi99pd 12 3 auch auch NNP cord-015365-iqdi99pd 12 4 kaum kaum NNP cord-015365-iqdi99pd 13 1 Berichte Berichte NNP cord-015365-iqdi99pd 14 1 über über NNP cord-015365-iqdi99pd 14 2 Stammzell Stammzell NNP cord-015365-iqdi99pd 14 3 - - HYPH cord-015365-iqdi99pd 14 4 Transplantationen Transplantationen NNP cord-015365-iqdi99pd 14 5 ( ( -LRB- cord-015365-iqdi99pd 14 6 SCT SCT NNP cord-015365-iqdi99pd 14 7 ) ) -RRB- cord-015365-iqdi99pd 14 8 bei bei NNP cord-015365-iqdi99pd 14 9 diesen diesen NNP cord-015365-iqdi99pd 14 10 Krankheitsbildern Krankheitsbildern NNP cord-015365-iqdi99pd 14 11 . . . cord-015365-iqdi99pd 15 1 Methodik Methodik NNP cord-015365-iqdi99pd 15 2 . . . cord-015365-iqdi99pd 16 1 Bei Bei NNP cord-015365-iqdi99pd 16 2 6 6 CD cord-015365-iqdi99pd 17 1 Patienten Patienten NNP cord-015365-iqdi99pd 17 2 mit mit NNP cord-015365-iqdi99pd 17 3 SAA SAA NNP cord-015365-iqdi99pd 17 4 ( ( -LRB- cord-015365-iqdi99pd 17 5 n n NN cord-015365-iqdi99pd 17 6 ¼ ¼ NNP cord-015365-iqdi99pd 17 7 4 4 CD cord-015365-iqdi99pd 17 8 ) ) -RRB- cord-015365-iqdi99pd 18 1 oder oder NNP cord-015365-iqdi99pd 18 2 MDS MDS NNP cord-015365-iqdi99pd 18 3 ( ( -LRB- cord-015365-iqdi99pd 18 4 n n NN cord-015365-iqdi99pd 18 5 ¼ ¼ NNP cord-015365-iqdi99pd 18 6 2 2 CD cord-015365-iqdi99pd 18 7 ) ) -RRB- cord-015365-iqdi99pd 18 8 wurde wurde NNP cord-015365-iqdi99pd 18 9 bei bei NNP cord-015365-iqdi99pd 18 10 Diagnosestellung Diagnosestellung NNP cord-015365-iqdi99pd 18 11 eine eine JJ cord-015365-iqdi99pd 18 12 frische frische JJ cord-015365-iqdi99pd 18 13 Infektion Infektion NNP cord-015365-iqdi99pd 18 14 mit mit NNP cord-015365-iqdi99pd 18 15 PVB19 PVB19 NNP cord-015365-iqdi99pd 18 16 mittels mittels NNP cord-015365-iqdi99pd 18 17 positivem positivem NNP cord-015365-iqdi99pd 18 18 Nachweis Nachweis NNP cord-015365-iqdi99pd 18 19 von von NNP cord-015365-iqdi99pd 18 20 IgM IgM NNP cord-015365-iqdi99pd 18 21 , , , cord-015365-iqdi99pd 18 22 IgG IgG NNP cord-015365-iqdi99pd 18 23 und und IN cord-015365-iqdi99pd 18 24 PCR PCR NNP cord-015365-iqdi99pd 18 25 nachgewiesen nachgewiesen NNP cord-015365-iqdi99pd 18 26 . . . cord-015365-iqdi99pd 19 1 Alle Alle NNP cord-015365-iqdi99pd 19 2 Patienten Patienten NNP cord-015365-iqdi99pd 19 3 erhielten erhielten XX cord-015365-iqdi99pd 19 4 eine eine NNP cord-015365-iqdi99pd 20 1 SCT SCT NNP cord-015365-iqdi99pd 20 2 unter unter NNP cord-015365-iqdi99pd 20 3 dem dem JJ cord-015365-iqdi99pd 20 4 Schutz Schutz NNP cord-015365-iqdi99pd 20 5 repetitiver repetitiver NNP cord-015365-iqdi99pd 21 1 intravenöser intravenöser NNP cord-015365-iqdi99pd 21 2 Immunglobulin Immunglobulin NNP cord-015365-iqdi99pd 21 3 ( ( -LRB- cord-015365-iqdi99pd 21 4 IVIG)-Gaben ivig)-gaben NN cord-015365-iqdi99pd 21 5 . . . cord-015365-iqdi99pd 22 1 Das Das NNP cord-015365-iqdi99pd 22 2 virologische virologische NN cord-015365-iqdi99pd 22 3 Monitoring Monitoring NNP cord-015365-iqdi99pd 22 4 mittels mittels FW cord-015365-iqdi99pd 22 5 PCR PCR NNP cord-015365-iqdi99pd 22 6 erfolgte erfolgte NN cord-015365-iqdi99pd 22 7 in in IN cord-015365-iqdi99pd 22 8 5 5 CD cord-015365-iqdi99pd 22 9 von von NNP cord-015365-iqdi99pd 22 10 6 6 CD cord-015365-iqdi99pd 22 11 Fällen Fällen NNP cord-015365-iqdi99pd 22 12 in in IN cord-015365-iqdi99pd 22 13 der der NNP cord-015365-iqdi99pd 22 14 Akutphase Akutphase NNP cord-015365-iqdi99pd 22 15 wöchentlich wöchentlich NNP cord-015365-iqdi99pd 22 16 , , , cord-015365-iqdi99pd 22 17 danach danach NNP cord-015365-iqdi99pd 22 18 monatlich monatlich NNP cord-015365-iqdi99pd 23 1 bis bis NNP cord-015365-iqdi99pd 23 2 zur zur NNP cord-015365-iqdi99pd 23 3 hämatologischen hämatologischen NNP cord-015365-iqdi99pd 23 4 Rekonstituierung Rekonstituierung NNP cord-015365-iqdi99pd 23 5 . . . cord-015365-iqdi99pd 24 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 24 2 . . . cord-015365-iqdi99pd 25 1 Die die VBP cord-015365-iqdi99pd 25 2 4 4 CD cord-015365-iqdi99pd 25 3 Patienten Patienten NNP cord-015365-iqdi99pd 25 4 mit mit NNP cord-015365-iqdi99pd 25 5 SAA SAA NNP cord-015365-iqdi99pd 25 6 erhielten erhielten NN cord-015365-iqdi99pd 26 1 Knochenmark Knochenmark NNP cord-015365-iqdi99pd 26 2 eines eines NNP cord-015365-iqdi99pd 26 3 HLA HLA NNP cord-015365-iqdi99pd 26 4 - - HYPH cord-015365-iqdi99pd 26 5 identen identen NNP cord-015365-iqdi99pd 26 6 Geschwister Geschwister NNP cord-015365-iqdi99pd 26 7 - - HYPH cord-015365-iqdi99pd 26 8 Spenders Spenders NNPS cord-015365-iqdi99pd 26 9 ( ( -LRB- cord-015365-iqdi99pd 26 10 n n CC cord-015365-iqdi99pd 26 11 ¼ ¼ NNP cord-015365-iqdi99pd 26 12 3 3 CD cord-015365-iqdi99pd 26 13 ) ) -RRB- cord-015365-iqdi99pd 27 1 oder oder NNP cord-015365-iqdi99pd 27 2 HLA HLA NNP cord-015365-iqdi99pd 27 3 - - HYPH cord-015365-iqdi99pd 27 4 idente idente NNP cord-015365-iqdi99pd 27 5 hochgereinigte hochgereinigte NN cord-015365-iqdi99pd 27 6 , , , cord-015365-iqdi99pd 27 7 periphere periphere NNP cord-015365-iqdi99pd 27 8 Stammzellen Stammzellen NNP cord-015365-iqdi99pd 27 9 eines eines NNPS cord-015365-iqdi99pd 27 10 unverwandten unverwandten NNP cord-015365-iqdi99pd 27 11 Spenders Spenders NNPS cord-015365-iqdi99pd 27 12 ( ( -LRB- cord-015365-iqdi99pd 27 13 n n CC cord-015365-iqdi99pd 27 14 ¼ ¼ NNP cord-015365-iqdi99pd 27 15 1 1 CD cord-015365-iqdi99pd 27 16 ) ) -RRB- cord-015365-iqdi99pd 27 17 . . . cord-015365-iqdi99pd 28 1 Ein Ein NNP cord-015365-iqdi99pd 28 2 Patient Patient NNP cord-015365-iqdi99pd 28 3 entwickelte entwickelte NNP cord-015365-iqdi99pd 28 4 nach nach NNP cord-015365-iqdi99pd 28 5 SCT SCT NNP cord-015365-iqdi99pd 28 6 eine eine NNP cord-015365-iqdi99pd 28 7 chronische chronische NNP cord-015365-iqdi99pd 28 8 , , , cord-015365-iqdi99pd 28 9 hypoplastische hypoplastische NNP cord-015365-iqdi99pd 28 10 Anämie Anämie NNP cord-015365-iqdi99pd 28 11 , , , cord-015365-iqdi99pd 28 12 die die VB cord-015365-iqdi99pd 28 13 bis bis NNP cord-015365-iqdi99pd 28 14 zur zur XX cord-015365-iqdi99pd 29 1 vollständigen vollständigen NNP cord-015365-iqdi99pd 29 2 Blutbild Blutbild NNP cord-015365-iqdi99pd 29 3 - - HYPH cord-015365-iqdi99pd 29 4 Regeneration Regeneration NNP cord-015365-iqdi99pd 29 5 am be VBP cord-015365-iqdi99pd 29 6 Tag tag NN cord-015365-iqdi99pd 29 7 186 186 CD cord-015365-iqdi99pd 29 8 andauerte andauerte NNS cord-015365-iqdi99pd 29 9 . . . cord-015365-iqdi99pd 30 1 Der Der NNP cord-015365-iqdi99pd 30 2 Posttransplantations Posttransplantations NNP cord-015365-iqdi99pd 30 3 - - HYPH cord-015365-iqdi99pd 30 4 Verlauf Verlauf NNP cord-015365-iqdi99pd 30 5 der der NNP cord-015365-iqdi99pd 30 6 ü ü NN cord-015365-iqdi99pd 30 7 brigen brigen NNP cord-015365-iqdi99pd 30 8 3 3 CD cord-015365-iqdi99pd 31 1 Patienten Patienten NNP cord-015365-iqdi99pd 31 2 war war NN cord-015365-iqdi99pd 31 3 komplikationslos komplikationslos NNP cord-015365-iqdi99pd 31 4 mit mit NNP cord-015365-iqdi99pd 31 5 einem einem NNP cord-015365-iqdi99pd 31 6 Leukozyten Leukozyten NNP cord-015365-iqdi99pd 31 7 - - HYPH cord-015365-iqdi99pd 31 8 Engraftment Engraftment NNP cord-015365-iqdi99pd 31 9 nach nach NNP cord-015365-iqdi99pd 31 10 8 8 CD cord-015365-iqdi99pd 32 1 -31 -31 NFP cord-015365-iqdi99pd 32 2 Tagen Tagen NNP cord-015365-iqdi99pd 32 3 und und NNP cord-015365-iqdi99pd 32 4 einer einer NNP cord-015365-iqdi99pd 33 1 hämatologischen hämatologischen NNP cord-015365-iqdi99pd 33 2 Rekonstituierung Rekonstituierung NNP cord-015365-iqdi99pd 33 3 nach nach NNP cord-015365-iqdi99pd 33 4 36 36 CD cord-015365-iqdi99pd 33 5 - - SYM cord-015365-iqdi99pd 33 6 112 112 CD cord-015365-iqdi99pd 33 7 Tagen Tagen NNP cord-015365-iqdi99pd 33 8 . . . cord-015365-iqdi99pd 34 1 Die die VB cord-015365-iqdi99pd 34 2 2 2 CD cord-015365-iqdi99pd 35 1 Patienten Patienten NNP cord-015365-iqdi99pd 35 2 mit mit NNP cord-015365-iqdi99pd 35 3 MDS MDS NNP cord-015365-iqdi99pd 35 4 wurden wurden NNS cord-015365-iqdi99pd 35 5 nach nach NNP cord-015365-iqdi99pd 35 6 Konditionierung Konditionierung NNP cord-015365-iqdi99pd 35 7 mit mit NNP cord-015365-iqdi99pd 35 8 Thiotepa Thiotepa NNP cord-015365-iqdi99pd 35 9 , , , cord-015365-iqdi99pd 35 10 Fludarabin Fludarabin NNP cord-015365-iqdi99pd 35 11 und und IN cord-015365-iqdi99pd 35 12 ATG ATG NNP cord-015365-iqdi99pd 35 13 einer einer NNP cord-015365-iqdi99pd 35 14 SCT SCT NNP cord-015365-iqdi99pd 35 15 mit mit NNP cord-015365-iqdi99pd 35 16 unverwandten unverwandten NNP cord-015365-iqdi99pd 35 17 Spendern Spendern NNP cord-015365-iqdi99pd 35 18 ( ( -LRB- cord-015365-iqdi99pd 35 19 1x 1x JJ cord-015365-iqdi99pd 35 20 Knochenmark Knochenmark NNP cord-015365-iqdi99pd 35 21 , , , cord-015365-iqdi99pd 36 1 1x 1x NNP cord-015365-iqdi99pd 36 2 periphere periphere NNP cord-015365-iqdi99pd 36 3 hochgereinigte hochgereinigte NNP cord-015365-iqdi99pd 37 1 Stammzellen Stammzellen NNP cord-015365-iqdi99pd 37 2 ) ) -RRB- cord-015365-iqdi99pd 37 3 unterzogen unterzogen NNP cord-015365-iqdi99pd 37 4 . . . cord-015365-iqdi99pd 38 1 Nach Nach NNP cord-015365-iqdi99pd 38 2 zögerlichem zögerlichem NNP cord-015365-iqdi99pd 38 3 Leukozyten Leukozyten NNP cord-015365-iqdi99pd 38 4 - - HYPH cord-015365-iqdi99pd 38 5 Engraftment Engraftment NNP cord-015365-iqdi99pd 38 6 dauerte dauerte NNS cord-015365-iqdi99pd 39 1 es es NNP cord-015365-iqdi99pd 39 2 1260 1260 CD cord-015365-iqdi99pd 39 3 bzw bzw NNP cord-015365-iqdi99pd 39 4 . . . cord-015365-iqdi99pd 40 1 119 119 CD cord-015365-iqdi99pd 40 2 Tage tage NN cord-015365-iqdi99pd 40 3 bis bis NN cord-015365-iqdi99pd 40 4 zur zur NNP cord-015365-iqdi99pd 40 5 Blutbild Blutbild NNP cord-015365-iqdi99pd 40 6 - - HYPH cord-015365-iqdi99pd 40 7 Normalisierung Normalisierung NNP cord-015365-iqdi99pd 41 1 , , , cord-015365-iqdi99pd 41 2 PVB19 PVB19 NNP cord-015365-iqdi99pd 41 3 wurde wurde NNP cord-015365-iqdi99pd 41 4 in in IN cord-015365-iqdi99pd 41 5 der der NNP cord-015365-iqdi99pd 41 6 PCR PCR NNP cord-015365-iqdi99pd 41 7 bis bis NN cord-015365-iqdi99pd 41 8 zum zum NN cord-015365-iqdi99pd 41 9 Tag tag NN cord-015365-iqdi99pd 41 10 686 686 CD cord-015365-iqdi99pd 41 11 bzw bzw NN cord-015365-iqdi99pd 41 12 . . . cord-015365-iqdi99pd 42 1 139 139 CD cord-015365-iqdi99pd 42 2 nachgewiesen nachgewiesen NNP cord-015365-iqdi99pd 42 3 . . . cord-015365-iqdi99pd 43 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 43 2 . . . cord-015365-iqdi99pd 44 1 Eine Eine NNP cord-015365-iqdi99pd 44 2 erfolgreiche erfolgreiche NN cord-015365-iqdi99pd 44 3 SCT SCT NNP cord-015365-iqdi99pd 44 4 bei bei NNP cord-015365-iqdi99pd 44 5 diesen diesen NNP cord-015365-iqdi99pd 45 1 Patienten Patienten NNP cord-015365-iqdi99pd 45 2 ist ist NN cord-015365-iqdi99pd 45 3 möglich möglich NNP cord-015365-iqdi99pd 45 4 , , , cord-015365-iqdi99pd 45 5 sofern sofern NNP cord-015365-iqdi99pd 45 6 eine eine NNP cord-015365-iqdi99pd 45 7 engmaschige engmaschige NNP cord-015365-iqdi99pd 45 8 Monitorisierung Monitorisierung NNP cord-015365-iqdi99pd 45 9 der der NNP cord-015365-iqdi99pd 45 10 PVB19-PCR pvb19-pcr FW cord-015365-iqdi99pd 45 11 und und IN cord-015365-iqdi99pd 46 1 eine eine NNP cord-015365-iqdi99pd 46 2 konsequente konsequente NNP cord-015365-iqdi99pd 46 3 repetitive repetitive JJ cord-015365-iqdi99pd 46 4 IVIG IVIG NNP cord-015365-iqdi99pd 46 5 - - HYPH cord-015365-iqdi99pd 46 6 Therapie Therapie NNP cord-015365-iqdi99pd 46 7 erfolgen erfolgen NN cord-015365-iqdi99pd 46 8 . . . cord-015365-iqdi99pd 47 1 Der Der NNP cord-015365-iqdi99pd 47 2 Transplantationsverlauf Transplantationsverlauf NNP cord-015365-iqdi99pd 47 3 kann kann NNP cord-015365-iqdi99pd 47 4 durch durch NNP cord-015365-iqdi99pd 47 5 ein ein FW cord-015365-iqdi99pd 47 6 zögerliches zögerliches NNP cord-015365-iqdi99pd 47 7 Engraftment Engraftment NNP cord-015365-iqdi99pd 47 8 und und XX cord-015365-iqdi99pd 48 1 eine eine NNP cord-015365-iqdi99pd 48 2 prolongierte prolongierte NNP cord-015365-iqdi99pd 48 3 " " `` cord-015365-iqdi99pd 48 4 poor poor JJ cord-015365-iqdi99pd 48 5 graft graft NN cord-015365-iqdi99pd 48 6 function function NN cord-015365-iqdi99pd 48 7 " " `` cord-015365-iqdi99pd 48 8 kompliziert kompliziert NNP cord-015365-iqdi99pd 48 9 werden werden NNP cord-015365-iqdi99pd 48 10 . . . cord-015365-iqdi99pd 49 1 Retrospective retrospective JJ cord-015365-iqdi99pd 49 2 study study NN cord-015365-iqdi99pd 49 3 to to TO cord-015365-iqdi99pd 49 4 test test VB cord-015365-iqdi99pd 49 5 ferritin ferritin NN cord-015365-iqdi99pd 49 6 serum serum NN cord-015365-iqdi99pd 49 7 levels level NNS cord-015365-iqdi99pd 49 8 as as IN cord-015365-iqdi99pd 49 9 biomarker biomarker NN cord-015365-iqdi99pd 49 10 for for IN cord-015365-iqdi99pd 49 11 graft graft NN cord-015365-iqdi99pd 49 12 - - HYPH cord-015365-iqdi99pd 49 13 versus versus IN cord-015365-iqdi99pd 49 14 - - HYPH cord-015365-iqdi99pd 49 15 host host NN cord-015365-iqdi99pd 49 16 disease disease NN cord-015365-iqdi99pd 49 17 - - HYPH cord-015365-iqdi99pd 49 18 associated associate VBN cord-015365-iqdi99pd 49 19 non non JJ cord-015365-iqdi99pd 49 20 - - JJ cord-015365-iqdi99pd 49 21 infectious infectious JJ cord-015365-iqdi99pd 49 22 inflammatory inflammatory JJ cord-015365-iqdi99pd 49 23 reaction reaction NN cord-015365-iqdi99pd 49 24 in in IN cord-015365-iqdi99pd 49 25 117 117 CD cord-015365-iqdi99pd 49 26 children child NNS cord-015365-iqdi99pd 49 27 after after IN cord-015365-iqdi99pd 49 28 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 49 29 stem stem NN cord-015365-iqdi99pd 49 30 cell cell NN cord-015365-iqdi99pd 49 31 transplantation transplantation NN cord-015365-iqdi99pd 49 32 Background Background NNP cord-015365-iqdi99pd 49 33 . . . cord-015365-iqdi99pd 50 1 Myelodysplastic myelodysplastic JJ cord-015365-iqdi99pd 50 2 syndromes syndrome NNS cord-015365-iqdi99pd 50 3 ( ( -LRB- cord-015365-iqdi99pd 50 4 MDS MDS NNP cord-015365-iqdi99pd 50 5 ) ) -RRB- cord-015365-iqdi99pd 50 6 are be VBP cord-015365-iqdi99pd 50 7 a a DT cord-015365-iqdi99pd 50 8 heterogeneous heterogeneous JJ cord-015365-iqdi99pd 50 9 group group NN cord-015365-iqdi99pd 50 10 of of IN cord-015365-iqdi99pd 50 11 stem stem NN cord-015365-iqdi99pd 50 12 cell cell NN cord-015365-iqdi99pd 50 13 disorders disorder NNS cord-015365-iqdi99pd 50 14 characterized characterize VBN cord-015365-iqdi99pd 50 15 by by IN cord-015365-iqdi99pd 50 16 bone bone NN cord-015365-iqdi99pd 50 17 marrow marrow NN cord-015365-iqdi99pd 50 18 dysplasia dysplasia NN cord-015365-iqdi99pd 50 19 , , , cord-015365-iqdi99pd 50 20 peripheral peripheral JJ cord-015365-iqdi99pd 50 21 cytopenia cytopenia NNS cord-015365-iqdi99pd 50 22 , , , cord-015365-iqdi99pd 50 23 and and CC cord-015365-iqdi99pd 50 24 an an DT cord-015365-iqdi99pd 50 25 enhanced enhanced JJ cord-015365-iqdi99pd 50 26 risk risk NN cord-015365-iqdi99pd 50 27 to to TO cord-015365-iqdi99pd 50 28 transform transform VB cord-015365-iqdi99pd 50 29 to to IN cord-015365-iqdi99pd 50 30 acute acute JJ cord-015365-iqdi99pd 50 31 myeloid myeloid NN cord-015365-iqdi99pd 50 32 leukemia leukemia NN cord-015365-iqdi99pd 50 33 ( ( -LRB- cord-015365-iqdi99pd 50 34 AML AML NNP cord-015365-iqdi99pd 50 35 ) ) -RRB- cord-015365-iqdi99pd 50 36 . . . cord-015365-iqdi99pd 51 1 In in IN cord-015365-iqdi99pd 51 2 most most JJS cord-015365-iqdi99pd 51 3 patients patient NNS cord-015365-iqdi99pd 51 4 , , , cord-015365-iqdi99pd 51 5 treatment treatment NN cord-015365-iqdi99pd 51 6 options option NNS cord-015365-iqdi99pd 51 7 are be VBP cord-015365-iqdi99pd 51 8 limited limit VBN cord-015365-iqdi99pd 51 9 to to IN cord-015365-iqdi99pd 51 10 supportive supportive JJ cord-015365-iqdi99pd 51 11 care care NN cord-015365-iqdi99pd 51 12 and and CC cord-015365-iqdi99pd 51 13 palliative palliative JJ cord-015365-iqdi99pd 51 14 cytoreduction cytoreduction NN cord-015365-iqdi99pd 51 15 . . . cord-015365-iqdi99pd 52 1 However however RB cord-015365-iqdi99pd 52 2 , , , cord-015365-iqdi99pd 52 3 in in IN cord-015365-iqdi99pd 52 4 a a DT cord-015365-iqdi99pd 52 5 group group NN cord-015365-iqdi99pd 52 6 of of IN cord-015365-iqdi99pd 52 7 patients patient NNS cord-015365-iqdi99pd 52 8 , , , cord-015365-iqdi99pd 52 9 intensive intensive JJ cord-015365-iqdi99pd 52 10 therapy therapy NN cord-015365-iqdi99pd 52 11 can can MD cord-015365-iqdi99pd 52 12 be be VB cord-015365-iqdi99pd 52 13 offered offer VBN cord-015365-iqdi99pd 52 14 . . . cord-015365-iqdi99pd 53 1 The the DT cord-015365-iqdi99pd 53 2 only only RB cord-015365-iqdi99pd 53 3 established establish VBN cord-015365-iqdi99pd 53 4 curative curative JJ cord-015365-iqdi99pd 53 5 treatment treatment NN cord-015365-iqdi99pd 53 6 approach approach NN cord-015365-iqdi99pd 53 7 for for IN cord-015365-iqdi99pd 53 8 these these DT cord-015365-iqdi99pd 53 9 patients patient NNS cord-015365-iqdi99pd 53 10 is be VBZ cord-015365-iqdi99pd 53 11 haematopoietic haematopoietic JJ cord-015365-iqdi99pd 53 12 stem stem NN cord-015365-iqdi99pd 53 13 cell cell NN cord-015365-iqdi99pd 53 14 transplantation transplantation NN cord-015365-iqdi99pd 53 15 ( ( -LRB- cord-015365-iqdi99pd 53 16 SCT SCT NNP cord-015365-iqdi99pd 53 17 ) ) -RRB- cord-015365-iqdi99pd 53 18 . . . cord-015365-iqdi99pd 54 1 Methods method NNS cord-015365-iqdi99pd 54 2 . . . cord-015365-iqdi99pd 55 1 In in IN cord-015365-iqdi99pd 55 2 the the DT cord-015365-iqdi99pd 55 3 present present JJ cord-015365-iqdi99pd 55 4 study study NN cord-015365-iqdi99pd 55 5 , , , cord-015365-iqdi99pd 55 6 we -PRON- PRP cord-015365-iqdi99pd 55 7 retrospectively retrospectively RB cord-015365-iqdi99pd 55 8 analyzed analyze VBD cord-015365-iqdi99pd 55 9 a a DT cord-015365-iqdi99pd 55 10 cohort cohort NN cord-015365-iqdi99pd 55 11 of of IN cord-015365-iqdi99pd 55 12 60 60 CD cord-015365-iqdi99pd 55 13 adult adult NN cord-015365-iqdi99pd 55 14 patients patient NNS cord-015365-iqdi99pd 55 15 ( ( -LRB- cord-015365-iqdi99pd 55 16 33 33 CD cord-015365-iqdi99pd 55 17 males male NNS cord-015365-iqdi99pd 55 18 , , , cord-015365-iqdi99pd 55 19 27 27 CD cord-015365-iqdi99pd 55 20 females female NNS cord-015365-iqdi99pd 55 21 ) ) -RRB- cord-015365-iqdi99pd 55 22 with with IN cord-015365-iqdi99pd 55 23 MDS MDS NNP cord-015365-iqdi99pd 55 24 ( ( -LRB- cord-015365-iqdi99pd 55 25 n n NN cord-015365-iqdi99pd 55 26 ¼ ¼ NNP cord-015365-iqdi99pd 55 27 28 28 CD cord-015365-iqdi99pd 55 28 ) ) -RRB- cord-015365-iqdi99pd 55 29 or or CC cord-015365-iqdi99pd 55 30 MDS MDS NNP cord-015365-iqdi99pd 55 31 transforming transform VBG cord-015365-iqdi99pd 55 32 into into IN cord-015365-iqdi99pd 55 33 secondary secondary JJ cord-015365-iqdi99pd 55 34 AML AML NNP cord-015365-iqdi99pd 55 35 ( ( -LRB- cord-015365-iqdi99pd 55 36 n n NN cord-015365-iqdi99pd 55 37 ¼ ¼ NNP cord-015365-iqdi99pd 55 38 33 33 CD cord-015365-iqdi99pd 55 39 ) ) -RRB- cord-015365-iqdi99pd 55 40 , , , cord-015365-iqdi99pd 55 41 who who WP cord-015365-iqdi99pd 55 42 underwent undergo VBD cord-015365-iqdi99pd 55 43 SCT SCT NNP cord-015365-iqdi99pd 55 44 at at IN cord-015365-iqdi99pd 55 45 our -PRON- PRP$ cord-015365-iqdi99pd 55 46 institution institution NN cord-015365-iqdi99pd 55 47 between between IN cord-015365-iqdi99pd 55 48 1988 1988 CD cord-015365-iqdi99pd 55 49 and and CC cord-015365-iqdi99pd 55 50 2010 2010 CD cord-015365-iqdi99pd 55 51 . . . cord-015365-iqdi99pd 56 1 Fifty fifty CD cord-015365-iqdi99pd 56 2 - - HYPH cord-015365-iqdi99pd 56 3 one one CD cord-015365-iqdi99pd 56 4 patients patient NNS cord-015365-iqdi99pd 56 5 had have VBD cord-015365-iqdi99pd 56 6 an an DT cord-015365-iqdi99pd 56 7 HLA HLA NNP cord-015365-iqdi99pd 56 8 - - HYPH cord-015365-iqdi99pd 56 9 identical identical JJ cord-015365-iqdi99pd 56 10 related related JJ cord-015365-iqdi99pd 56 11 transplant transplant NN cord-015365-iqdi99pd 56 12 donor donor NN cord-015365-iqdi99pd 56 13 , , , cord-015365-iqdi99pd 56 14 and and CC cord-015365-iqdi99pd 56 15 9 9 CD cord-015365-iqdi99pd 56 16 had have VBD cord-015365-iqdi99pd 56 17 an an DT cord-015365-iqdi99pd 56 18 HLA HLA NNP cord-015365-iqdi99pd 56 19 - - HYPH cord-015365-iqdi99pd 56 20 matched match VBN cord-015365-iqdi99pd 56 21 unrelated unrelated JJ cord-015365-iqdi99pd 56 22 donor donor NN cord-015365-iqdi99pd 56 23 . . . cord-015365-iqdi99pd 57 1 The the DT cord-015365-iqdi99pd 57 2 median median JJ cord-015365-iqdi99pd 57 3 age age NN cord-015365-iqdi99pd 57 4 at at IN cord-015365-iqdi99pd 57 5 time time NN cord-015365-iqdi99pd 57 6 of of IN cord-015365-iqdi99pd 57 7 SCT SCT NNP cord-015365-iqdi99pd 57 8 was be VBD cord-015365-iqdi99pd 57 9 44 44 CD cord-015365-iqdi99pd 57 10 years year NNS cord-015365-iqdi99pd 58 1 ( ( -LRB- cord-015365-iqdi99pd 58 2 range range NN cord-015365-iqdi99pd 58 3 : : : cord-015365-iqdi99pd 58 4 18 18 CD cord-015365-iqdi99pd 58 5 to to TO cord-015365-iqdi99pd 58 6 68 68 CD cord-015365-iqdi99pd 58 7 years year NNS cord-015365-iqdi99pd 58 8 ) ) -RRB- cord-015365-iqdi99pd 58 9 . . . cord-015365-iqdi99pd 59 1 According accord VBG cord-015365-iqdi99pd 59 2 to to IN cord-015365-iqdi99pd 59 3 the the DT cord-015365-iqdi99pd 59 4 WHO who WP cord-015365-iqdi99pd 59 5 classification classification NN cord-015365-iqdi99pd 59 6 , , , cord-015365-iqdi99pd 59 7 4 4 CD cord-015365-iqdi99pd 59 8 patients patient NNS cord-015365-iqdi99pd 59 9 had have VBD cord-015365-iqdi99pd 59 10 RA RA NNP cord-015365-iqdi99pd 59 11 , , , cord-015365-iqdi99pd 59 12 1 1 CD cord-015365-iqdi99pd 59 13 RARS rar NNS cord-015365-iqdi99pd 59 14 , , , cord-015365-iqdi99pd 59 15 3 3 CD cord-015365-iqdi99pd 59 16 RCMD RCMD NNS cord-015365-iqdi99pd 59 17 , , , cord-015365-iqdi99pd 59 18 1 1 CD cord-015365-iqdi99pd 59 19 RCMD rcmd NN cord-015365-iqdi99pd 59 20 - - HYPH cord-015365-iqdi99pd 59 21 RS RS NNP cord-015365-iqdi99pd 59 22 , , , cord-015365-iqdi99pd 59 23 6 6 CD cord-015365-iqdi99pd 59 24 RAEB-1 RAEB-1 NNP cord-015365-iqdi99pd 59 25 , , , cord-015365-iqdi99pd 59 26 12 12 CD cord-015365-iqdi99pd 59 27 RAEB-2 RAEB-2 NNS cord-015365-iqdi99pd 59 28 , , , cord-015365-iqdi99pd 59 29 1 1 CD cord-015365-iqdi99pd 59 30 CMML CMML NNP cord-015365-iqdi99pd 59 31 , , , cord-015365-iqdi99pd 59 32 and and CC cord-015365-iqdi99pd 59 33 32 32 CD cord-015365-iqdi99pd 59 34 had have VBD cord-015365-iqdi99pd 59 35 AML AML NNP cord-015365-iqdi99pd 59 36 following follow VBG cord-015365-iqdi99pd 59 37 RAEB RAEB NNP cord-015365-iqdi99pd 59 38 at at IN cord-015365-iqdi99pd 59 39 SCT SCT NNP cord-015365-iqdi99pd 59 40 . . . cord-015365-iqdi99pd 60 1 Conditioning conditioning NN cord-015365-iqdi99pd 60 2 consisted consist VBD cord-015365-iqdi99pd 60 3 of of IN cord-015365-iqdi99pd 60 4 chemotherapy chemotherapy NN cord-015365-iqdi99pd 60 5 plus plus CC cord-015365-iqdi99pd 60 6 total total JJ cord-015365-iqdi99pd 60 7 body body NN cord-015365-iqdi99pd 60 8 irradiation irradiation NN cord-015365-iqdi99pd 60 9 ( ( -LRB- cord-015365-iqdi99pd 60 10 55/60 55/60 CD cord-015365-iqdi99pd 60 11 patients patient NNS cord-015365-iqdi99pd 60 12 ) ) -RRB- cord-015365-iqdi99pd 60 13 or or CC cord-015365-iqdi99pd 60 14 chemotherapy chemotherapy NN cord-015365-iqdi99pd 60 15 alone alone JJ cord-015365-iqdi99pd 60 16 ( ( -LRB- cord-015365-iqdi99pd 60 17 5/60 5/60 CD cord-015365-iqdi99pd 60 18 patients patient NNS cord-015365-iqdi99pd 60 19 ) ) -RRB- cord-015365-iqdi99pd 60 20 . . . cord-015365-iqdi99pd 61 1 Graft graft NN cord-015365-iqdi99pd 61 2 versus versus IN cord-015365-iqdi99pd 61 3 host host NN cord-015365-iqdi99pd 61 4 disease disease NN cord-015365-iqdi99pd 61 5 ( ( -LRB- cord-015365-iqdi99pd 61 6 GvHD GvHD NNP cord-015365-iqdi99pd 61 7 ) ) -RRB- cord-015365-iqdi99pd 61 8 prophylaxis prophylaxis NN cord-015365-iqdi99pd 61 9 consisted consist VBD cord-015365-iqdi99pd 61 10 of of IN cord-015365-iqdi99pd 61 11 a a DT cord-015365-iqdi99pd 61 12 combination combination NN cord-015365-iqdi99pd 61 13 of of IN cord-015365-iqdi99pd 61 14 low low JJ cord-015365-iqdi99pd 61 15 - - HYPH cord-015365-iqdi99pd 61 16 dose dose NN cord-015365-iqdi99pd 61 17 methotrexate methotrexate NNP cord-015365-iqdi99pd 61 18 and and CC cord-015365-iqdi99pd 61 19 cyclosporine cyclosporine NNP cord-015365-iqdi99pd 61 20 A A NNP cord-015365-iqdi99pd 61 21 ( ( -LRB- cord-015365-iqdi99pd 61 22 37/60 37/60 CD cord-015365-iqdi99pd 61 23 patients patient NNS cord-015365-iqdi99pd 61 24 ) ) -RRB- cord-015365-iqdi99pd 61 25 or or CC cord-015365-iqdi99pd 61 26 cyclosporine cyclosporine NNP cord-015365-iqdi99pd 61 27 A A NNP cord-015365-iqdi99pd 61 28 plus plus CC cord-015365-iqdi99pd 61 29 mycophenolat mycophenolat NNP cord-015365-iqdi99pd 61 30 mofetil mofetil NNP cord-015365-iqdi99pd 61 31 ( ( -LRB- cord-015365-iqdi99pd 61 32 23/60 23/60 CD cord-015365-iqdi99pd 61 33 patients patient NNS cord-015365-iqdi99pd 61 34 ) ) -RRB- cord-015365-iqdi99pd 61 35 . . . cord-015365-iqdi99pd 62 1 Results result NNS cord-015365-iqdi99pd 62 2 . . . cord-015365-iqdi99pd 63 1 Patients patient NNS cord-015365-iqdi99pd 63 2 were be VBD cord-015365-iqdi99pd 63 3 followed follow VBN cord-015365-iqdi99pd 63 4 up up RP cord-015365-iqdi99pd 63 5 with with IN cord-015365-iqdi99pd 63 6 a a DT cord-015365-iqdi99pd 63 7 median median JJ cord-015365-iqdi99pd 63 8 observation observation NN cord-015365-iqdi99pd 63 9 time time NN cord-015365-iqdi99pd 63 10 of of IN cord-015365-iqdi99pd 63 11 16 16 CD cord-015365-iqdi99pd 63 12 months month NNS cord-015365-iqdi99pd 63 13 ( ( -LRB- cord-015365-iqdi99pd 63 14 range range NN cord-015365-iqdi99pd 63 15 : : : cord-015365-iqdi99pd 63 16 1 1 CD cord-015365-iqdi99pd 63 17 - - SYM cord-015365-iqdi99pd 63 18 218 218 CD cord-015365-iqdi99pd 63 19 ) ) -RRB- cord-015365-iqdi99pd 63 20 . . . cord-015365-iqdi99pd 64 1 Currently currently RB cord-015365-iqdi99pd 64 2 , , , cord-015365-iqdi99pd 64 3 34 34 CD cord-015365-iqdi99pd 64 4 patients patient NNS cord-015365-iqdi99pd 64 5 ( ( -LRB- cord-015365-iqdi99pd 64 6 57 57 CD cord-015365-iqdi99pd 64 7 % % NN cord-015365-iqdi99pd 64 8 ) ) -RRB- cord-015365-iqdi99pd 64 9 are be VBP cord-015365-iqdi99pd 64 10 alive alive JJ cord-015365-iqdi99pd 64 11 . . . cord-015365-iqdi99pd 65 1 Of of IN cord-015365-iqdi99pd 65 2 the the DT cord-015365-iqdi99pd 65 3 26 26 CD cord-015365-iqdi99pd 65 4 patients patient NNS cord-015365-iqdi99pd 65 5 who who WP cord-015365-iqdi99pd 65 6 died die VBD cord-015365-iqdi99pd 65 7 , , , cord-015365-iqdi99pd 65 8 post post JJ cord-015365-iqdi99pd 65 9 - - NN cord-015365-iqdi99pd 65 10 transplantation transplantation JJ cord-015365-iqdi99pd 65 11 relapse relapse NN cord-015365-iqdi99pd 65 12 occurred occur VBD cord-015365-iqdi99pd 65 13 in in IN cord-015365-iqdi99pd 65 14 12 12 CD cord-015365-iqdi99pd 65 15 patients patient NNS cord-015365-iqdi99pd 65 16 , , , cord-015365-iqdi99pd 65 17 and and CC cord-015365-iqdi99pd 65 18 14 14 CD cord-015365-iqdi99pd 65 19 patients patient NNS cord-015365-iqdi99pd 65 20 died die VBD cord-015365-iqdi99pd 65 21 of of IN cord-015365-iqdi99pd 65 22 treatment treatment NN cord-015365-iqdi99pd 65 23 - - HYPH cord-015365-iqdi99pd 65 24 related relate VBN cord-015365-iqdi99pd 65 25 causes cause NNS cord-015365-iqdi99pd 65 26 ( ( -LRB- cord-015365-iqdi99pd 65 27 multi multi JJ cord-015365-iqdi99pd 65 28 - - JJ cord-015365-iqdi99pd 65 29 organ organ JJ cord-015365-iqdi99pd 65 30 failure failure NN cord-015365-iqdi99pd 65 31 , , , cord-015365-iqdi99pd 65 32 n n NN cord-015365-iqdi99pd 65 33 ¼ ¼ NNP cord-015365-iqdi99pd 65 34 7 7 CD cord-015365-iqdi99pd 65 35 ; ; : cord-015365-iqdi99pd 65 36 sepsis sepsis NN cord-015365-iqdi99pd 65 37 , , , cord-015365-iqdi99pd 65 38 n n NN cord-015365-iqdi99pd 65 39 ¼ ¼ NNP cord-015365-iqdi99pd 65 40 4 4 CD cord-015365-iqdi99pd 65 41 ; ; : cord-015365-iqdi99pd 65 42 haemorrhage haemorrhage NN cord-015365-iqdi99pd 65 43 , , , cord-015365-iqdi99pd 65 44 n n NN cord-015365-iqdi99pd 65 45 ¼ ¼ NNP cord-015365-iqdi99pd 65 46 3 3 CD cord-015365-iqdi99pd 65 47 ) ) -RRB- cord-015365-iqdi99pd 65 48 . . . cord-015365-iqdi99pd 66 1 In in IN cord-015365-iqdi99pd 66 2 multivariate multivariate JJ cord-015365-iqdi99pd 66 3 analysis analysis NN cord-015365-iqdi99pd 66 4 we -PRON- PRP cord-015365-iqdi99pd 66 5 identified identify VBD cord-015365-iqdi99pd 66 6 pre pre JJ cord-015365-iqdi99pd 66 7 - - JJ cord-015365-iqdi99pd 66 8 transplantation transplantation JJ cord-015365-iqdi99pd 66 9 ferritin ferritin NN cord-015365-iqdi99pd 66 10 as as IN cord-015365-iqdi99pd 66 11 a a DT cord-015365-iqdi99pd 66 12 significant significant JJ cord-015365-iqdi99pd 66 13 adverse adverse JJ cord-015365-iqdi99pd 66 14 prognostic prognostic JJ cord-015365-iqdi99pd 66 15 variable variable NN cord-015365-iqdi99pd 66 16 for for IN cord-015365-iqdi99pd 66 17 survival survival NN cord-015365-iqdi99pd 66 18 in in IN cord-015365-iqdi99pd 66 19 our -PRON- PRP$ cord-015365-iqdi99pd 66 20 MDS MDS NNP cord-015365-iqdi99pd 66 21 patients patient NNS cord-015365-iqdi99pd 66 22 . . . cord-015365-iqdi99pd 67 1 In in IN cord-015365-iqdi99pd 67 2 contrast contrast NN cord-015365-iqdi99pd 67 3 , , , cord-015365-iqdi99pd 67 4 the the DT cord-015365-iqdi99pd 67 5 overall overall JJ cord-015365-iqdi99pd 67 6 outcome outcome NN cord-015365-iqdi99pd 67 7 after after IN cord-015365-iqdi99pd 67 8 SCT SCT NNP cord-015365-iqdi99pd 67 9 was be VBD cord-015365-iqdi99pd 67 10 independent independent JJ cord-015365-iqdi99pd 67 11 of of IN cord-015365-iqdi99pd 67 12 IPSS IPSS NNP cord-015365-iqdi99pd 67 13 risk risk NN cord-015365-iqdi99pd 67 14 categories category NNS cord-015365-iqdi99pd 67 15 or or CC cord-015365-iqdi99pd 67 16 the the DT cord-015365-iqdi99pd 67 17 WHO who WP cord-015365-iqdi99pd 67 18 classification classification NN cord-015365-iqdi99pd 67 19 . . . cord-015365-iqdi99pd 68 1 Conclusions conclusion NNS cord-015365-iqdi99pd 68 2 . . . cord-015365-iqdi99pd 69 1 Based base VBN cord-015365-iqdi99pd 69 2 on on IN cord-015365-iqdi99pd 69 3 these these DT cord-015365-iqdi99pd 69 4 data datum NNS cord-015365-iqdi99pd 69 5 and and CC cord-015365-iqdi99pd 69 6 similar similar JJ cord-015365-iqdi99pd 69 7 published publish VBN cord-015365-iqdi99pd 69 8 data datum NNS cord-015365-iqdi99pd 69 9 we -PRON- PRP cord-015365-iqdi99pd 69 10 recommend recommend VBP cord-015365-iqdi99pd 69 11 to to TO cord-015365-iqdi99pd 69 12 select select VB cord-015365-iqdi99pd 69 13 patients patient NNS cord-015365-iqdi99pd 69 14 with with IN cord-015365-iqdi99pd 69 15 MDS MDS NNP cord-015365-iqdi99pd 69 16 or or CC cord-015365-iqdi99pd 69 17 sAML saml NN cord-015365-iqdi99pd 69 18 for for IN cord-015365-iqdi99pd 69 19 SCT SCT NNP cord-015365-iqdi99pd 69 20 who who WP cord-015365-iqdi99pd 69 21 are be VBP cord-015365-iqdi99pd 69 22 considered consider VBN cord-015365-iqdi99pd 69 23 candidates candidate NNS cord-015365-iqdi99pd 69 24 for for IN cord-015365-iqdi99pd 69 25 SCT SCT NNP cord-015365-iqdi99pd 69 26 according accord VBG cord-015365-iqdi99pd 69 27 to to IN cord-015365-iqdi99pd 69 28 the the DT cord-015365-iqdi99pd 69 29 presence presence NN cord-015365-iqdi99pd 69 30 of of IN cord-015365-iqdi99pd 69 31 pre pre JJ cord-015365-iqdi99pd 69 32 - - JJ cord-015365-iqdi99pd 69 33 transplantation transplantation JJ cord-015365-iqdi99pd 69 34 iron iron NN cord-015365-iqdi99pd 69 35 - - HYPH cord-015365-iqdi99pd 69 36 overload overload NN cord-015365-iqdi99pd 69 37 . . . cord-015365-iqdi99pd 70 1 Significantly significantly RB cord-015365-iqdi99pd 70 2 worse bad JJR cord-015365-iqdi99pd 70 3 survival survival NN cord-015365-iqdi99pd 70 4 of of IN cord-015365-iqdi99pd 70 5 patients patient NNS cord-015365-iqdi99pd 70 6 with with IN cord-015365-iqdi99pd 70 7 chronic chronic JJ cord-015365-iqdi99pd 70 8 graft graft NN cord-015365-iqdi99pd 70 9 - - HYPH cord-015365-iqdi99pd 70 10 versus versus IN cord-015365-iqdi99pd 70 11 - - HYPH cord-015365-iqdi99pd 70 12 host host NN cord-015365-iqdi99pd 70 13 disease disease NN cord-015365-iqdi99pd 70 14 ( ( -LRB- cord-015365-iqdi99pd 70 15 cGVHD cGVHD NNP cord-015365-iqdi99pd 70 16 ) ) -RRB- cord-015365-iqdi99pd 70 17 defined define VBN cord-015365-iqdi99pd 70 18 according accord VBG cord-015365-iqdi99pd 70 19 to to IN cord-015365-iqdi99pd 70 20 the the DT cord-015365-iqdi99pd 70 21 National National NNP cord-015365-iqdi99pd 70 22 Institutes Institutes NNPS cord-015365-iqdi99pd 70 23 of of IN cord-015365-iqdi99pd 70 24 Health Health NNP cord-015365-iqdi99pd 70 25 ( ( -LRB- cord-015365-iqdi99pd 70 26 NIH NIH NNP cord-015365-iqdi99pd 70 27 ) ) -RRB- cord-015365-iqdi99pd 70 28 consensus consensus NN cord-015365-iqdi99pd 70 29 criteria criterion NNS cord-015365-iqdi99pd 70 30 and and CC cord-015365-iqdi99pd 70 31 thrombocytopenia thrombocytopenia NN cord-015365-iqdi99pd 70 32 data datum NNS cord-015365-iqdi99pd 70 33 and and CC cord-015365-iqdi99pd 70 34 expert expert JJ cord-015365-iqdi99pd 70 35 opinion opinion NN cord-015365-iqdi99pd 70 36 . . . cord-015365-iqdi99pd 71 1 For for IN cord-015365-iqdi99pd 71 2 both both DT cord-015365-iqdi99pd 71 3 acute acute JJ cord-015365-iqdi99pd 71 4 as as RB cord-015365-iqdi99pd 71 5 well well RB cord-015365-iqdi99pd 71 6 as as IN cord-015365-iqdi99pd 71 7 cGVHD cgvhd JJ cord-015365-iqdi99pd 71 8 new new JJ cord-015365-iqdi99pd 71 9 definitions definition NNS cord-015365-iqdi99pd 71 10 were be VBD cord-015365-iqdi99pd 71 11 proposed propose VBN cord-015365-iqdi99pd 71 12 . . . cord-015365-iqdi99pd 72 1 We -PRON- PRP cord-015365-iqdi99pd 72 2 performed perform VBD cord-015365-iqdi99pd 72 3 a a DT cord-015365-iqdi99pd 72 4 prospective prospective JJ cord-015365-iqdi99pd 72 5 study study NN cord-015365-iqdi99pd 72 6 on on IN cord-015365-iqdi99pd 72 7 all all DT cord-015365-iqdi99pd 72 8 consecutive consecutive JJ cord-015365-iqdi99pd 72 9 patients patient NNS cord-015365-iqdi99pd 72 10 undergoing undergo VBG cord-015365-iqdi99pd 72 11 allogeneic allogeneic IN cord-015365-iqdi99pd 72 12 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 72 13 stem stem NN cord-015365-iqdi99pd 72 14 cell cell NN cord-015365-iqdi99pd 72 15 transplantation transplantation NN cord-015365-iqdi99pd 72 16 ( ( -LRB- cord-015365-iqdi99pd 72 17 HCT HCT NNP cord-015365-iqdi99pd 72 18 ) ) -RRB- cord-015365-iqdi99pd 72 19 since since IN cord-015365-iqdi99pd 72 20 2005 2005 CD cord-015365-iqdi99pd 72 21 to to TO cord-015365-iqdi99pd 72 22 assess assess VB cord-015365-iqdi99pd 72 23 the the DT cord-015365-iqdi99pd 72 24 prognostic prognostic JJ cord-015365-iqdi99pd 72 25 impact impact NN cord-015365-iqdi99pd 72 26 of of IN cord-015365-iqdi99pd 72 27 the the DT cord-015365-iqdi99pd 72 28 new new JJ cord-015365-iqdi99pd 72 29 cGVHD cgvhd NN cord-015365-iqdi99pd 72 30 staging stage VBG cord-015365-iqdi99pd 72 31 criteria criterion NNS cord-015365-iqdi99pd 72 32 . . . cord-015365-iqdi99pd 73 1 Methods method NNS cord-015365-iqdi99pd 73 2 . . . cord-015365-iqdi99pd 74 1 One one CD cord-015365-iqdi99pd 74 2 hundred hundred CD cord-015365-iqdi99pd 74 3 seventy seventy CD cord-015365-iqdi99pd 74 4 - - HYPH cord-015365-iqdi99pd 74 5 eight eight CD cord-015365-iqdi99pd 74 6 patients patient NNS cord-015365-iqdi99pd 74 7 ( ( -LRB- cord-015365-iqdi99pd 74 8 85 85 CD cord-015365-iqdi99pd 74 9 males male NNS cord-015365-iqdi99pd 74 10 , , , cord-015365-iqdi99pd 74 11 93 93 CD cord-015365-iqdi99pd 74 12 females female NNS cord-015365-iqdi99pd 74 13 ) ) -RRB- cord-015365-iqdi99pd 74 14 with with IN cord-015365-iqdi99pd 74 15 a a DT cord-015365-iqdi99pd 74 16 median median JJ cord-015365-iqdi99pd 74 17 age age NN cord-015365-iqdi99pd 74 18 of of IN cord-015365-iqdi99pd 74 19 40 40 CD cord-015365-iqdi99pd 74 20 years year NNS cord-015365-iqdi99pd 74 21 alive alive JJ cord-015365-iqdi99pd 74 22 on on IN cord-015365-iqdi99pd 74 23 day day NN cord-015365-iqdi99pd 74 24 þ þ NNP cord-015365-iqdi99pd 74 25 100 100 CD cord-015365-iqdi99pd 74 26 after after IN cord-015365-iqdi99pd 74 27 HCT HCT NNP cord-015365-iqdi99pd 74 28 with with IN cord-015365-iqdi99pd 74 29 myeloablative myeloablative NNP cord-015365-iqdi99pd 74 30 ( ( -LRB- cord-015365-iqdi99pd 74 31 n n NNP cord-015365-iqdi99pd 74 32 ¼ ¼ NNP cord-015365-iqdi99pd 74 33 110 110 CD cord-015365-iqdi99pd 74 34 ) ) -RRB- cord-015365-iqdi99pd 74 35 or or CC cord-015365-iqdi99pd 74 36 reduced reduce VBN cord-015365-iqdi99pd 74 37 - - HYPH cord-015365-iqdi99pd 74 38 intensity intensity NN cord-015365-iqdi99pd 74 39 ( ( -LRB- cord-015365-iqdi99pd 74 40 n n NN cord-015365-iqdi99pd 74 41 ¼ ¼ NNP cord-015365-iqdi99pd 74 42 68 68 CD cord-015365-iqdi99pd 74 43 ) ) -RRB- cord-015365-iqdi99pd 74 44 conditioning conditioning NN cord-015365-iqdi99pd 74 45 and and CC cord-015365-iqdi99pd 74 46 a a DT cord-015365-iqdi99pd 74 47 related related JJ cord-015365-iqdi99pd 74 48 ( ( -LRB- cord-015365-iqdi99pd 74 49 n n NN cord-015365-iqdi99pd 74 50 ¼ ¼ NNP cord-015365-iqdi99pd 74 51 37 37 CD cord-015365-iqdi99pd 74 52 ) ) -RRB- cord-015365-iqdi99pd 74 53 or or CC cord-015365-iqdi99pd 74 54 unrelated unrelated JJ cord-015365-iqdi99pd 74 55 ( ( -LRB- cord-015365-iqdi99pd 74 56 n n NNP cord-015365-iqdi99pd 74 57 ¼ ¼ NNP cord-015365-iqdi99pd 74 58 141 141 CD cord-015365-iqdi99pd 74 59 ) ) -RRB- cord-015365-iqdi99pd 74 60 stem stem NN cord-015365-iqdi99pd 74 61 cell cell NN cord-015365-iqdi99pd 74 62 donor donor NN cord-015365-iqdi99pd 74 63 were be VBD cord-015365-iqdi99pd 74 64 enrolled enrol VBN cord-015365-iqdi99pd 74 65 into into IN cord-015365-iqdi99pd 74 66 the the DT cord-015365-iqdi99pd 74 67 study study NN cord-015365-iqdi99pd 74 68 . . . cord-015365-iqdi99pd 75 1 Starting start VBG cord-015365-iqdi99pd 75 2 on on IN cord-015365-iqdi99pd 75 3 day day NN cord-015365-iqdi99pd 75 4 þ þ CD cord-015365-iqdi99pd 75 5 100 100 CD cord-015365-iqdi99pd 75 6 after after IN cord-015365-iqdi99pd 75 7 HCT HCT NNP cord-015365-iqdi99pd 75 8 all all DT cord-015365-iqdi99pd 75 9 patients patient NNS cord-015365-iqdi99pd 75 10 were be VBD cord-015365-iqdi99pd 75 11 assessed assess VBN cord-015365-iqdi99pd 75 12 clinically clinically RB cord-015365-iqdi99pd 75 13 every every DT cord-015365-iqdi99pd 75 14 3 3 CD cord-015365-iqdi99pd 75 15 months month NNS cord-015365-iqdi99pd 75 16 in in IN cord-015365-iqdi99pd 75 17 the the DT cord-015365-iqdi99pd 75 18 outpatient outpatient NN cord-015365-iqdi99pd 75 19 clinic clinic NN cord-015365-iqdi99pd 75 20 for for IN cord-015365-iqdi99pd 75 21 cGVHD cGVHD NNP cord-015365-iqdi99pd 75 22 activity activity NN cord-015365-iqdi99pd 75 23 according accord VBG cord-015365-iqdi99pd 75 24 to to IN cord-015365-iqdi99pd 75 25 the the DT cord-015365-iqdi99pd 75 26 NIH NIH NNP cord-015365-iqdi99pd 75 27 consensus consensus NN cord-015365-iqdi99pd 75 28 criteria criterion NNS cord-015365-iqdi99pd 75 29 ( ( -LRB- cord-015365-iqdi99pd 75 30 Filipovich Filipovich NNP cord-015365-iqdi99pd 75 31 AH AH NNP cord-015365-iqdi99pd 75 32 et et FW cord-015365-iqdi99pd 75 33 al al NNP cord-015365-iqdi99pd 75 34 , , , cord-015365-iqdi99pd 75 35 BBMT BBMT NNP cord-015365-iqdi99pd 75 36 2005 2005 CD cord-015365-iqdi99pd 75 37 ; ; : cord-015365-iqdi99pd 75 38 11:945 11:945 CD cord-015365-iqdi99pd 75 39 - - SYM cord-015365-iqdi99pd 75 40 956 956 CD cord-015365-iqdi99pd 75 41 ) ) -RRB- cord-015365-iqdi99pd 75 42 . . . cord-015365-iqdi99pd 76 1 Results result NNS cord-015365-iqdi99pd 76 2 . . . cord-015365-iqdi99pd 77 1 One one CD cord-015365-iqdi99pd 77 2 hundred hundred CD cord-015365-iqdi99pd 77 3 twenty twenty CD cord-015365-iqdi99pd 77 4 - - HYPH cord-015365-iqdi99pd 77 5 six six CD cord-015365-iqdi99pd 77 6 ( ( -LRB- cord-015365-iqdi99pd 77 7 71 71 CD cord-015365-iqdi99pd 77 8 % % NN cord-015365-iqdi99pd 77 9 ) ) -RRB- cord-015365-iqdi99pd 77 10 patients patient NNS cord-015365-iqdi99pd 77 11 experienced experience VBD cord-015365-iqdi99pd 77 12 acute acute JJ cord-015365-iqdi99pd 77 13 GVHD GVHD NNP cord-015365-iqdi99pd 77 14 grades grade NNS cord-015365-iqdi99pd 77 15 I -PRON- PRP cord-015365-iqdi99pd 77 16 to to IN cord-015365-iqdi99pd 77 17 IV IV NNP cord-015365-iqdi99pd 77 18 including include VBG cord-015365-iqdi99pd 77 19 11 11 CD cord-015365-iqdi99pd 77 20 with with IN cord-015365-iqdi99pd 77 21 recurrent recurrent JJ cord-015365-iqdi99pd 77 22 , , , cord-015365-iqdi99pd 77 23 11 11 CD cord-015365-iqdi99pd 77 24 with with IN cord-015365-iqdi99pd 77 25 persistent persistent JJ cord-015365-iqdi99pd 77 26 , , , cord-015365-iqdi99pd 77 27 and and CC cord-015365-iqdi99pd 77 28 10 10 CD cord-015365-iqdi99pd 77 29 with with IN cord-015365-iqdi99pd 77 30 late late JJ cord-015365-iqdi99pd 77 31 - - HYPH cord-015365-iqdi99pd 77 32 onset onset NN cord-015365-iqdi99pd 77 33 acute acute JJ cord-015365-iqdi99pd 77 34 GVHD GVHD NNP cord-015365-iqdi99pd 77 35 after after IN cord-015365-iqdi99pd 77 36 a a DT cord-015365-iqdi99pd 77 37 median median NN cord-015365-iqdi99pd 77 38 of of IN cord-015365-iqdi99pd 77 39 18 18 CD cord-015365-iqdi99pd 78 1 ( ( -LRB- cord-015365-iqdi99pd 78 2 range range NN cord-015365-iqdi99pd 78 3 , , , cord-015365-iqdi99pd 78 4 9 9 CD cord-015365-iqdi99pd 78 5 - - SYM cord-015365-iqdi99pd 78 6 120 120 CD cord-015365-iqdi99pd 78 7 ) ) -RRB- cord-015365-iqdi99pd 78 8 days day NNS cord-015365-iqdi99pd 78 9 after after IN cord-015365-iqdi99pd 78 10 HCT HCT NNP cord-015365-iqdi99pd 78 11 . . . cord-015365-iqdi99pd 79 1 One one CD cord-015365-iqdi99pd 79 2 hundred hundred CD cord-015365-iqdi99pd 79 3 - - HYPH cord-015365-iqdi99pd 79 4 fifteen fifteen CD cord-015365-iqdi99pd 79 5 patients patient NNS cord-015365-iqdi99pd 79 6 ( ( -LRB- cord-015365-iqdi99pd 79 7 65 65 CD cord-015365-iqdi99pd 79 8 % % NN cord-015365-iqdi99pd 79 9 ) ) -RRB- cord-015365-iqdi99pd 79 10 experienced experience VBD cord-015365-iqdi99pd 79 11 cGVHD cgvhd NN cord-015365-iqdi99pd 79 12 after after IN cord-015365-iqdi99pd 79 13 a a DT cord-015365-iqdi99pd 79 14 median median NN cord-015365-iqdi99pd 79 15 of of IN cord-015365-iqdi99pd 79 16 151 151 CD cord-015365-iqdi99pd 79 17 ( ( -LRB- cord-015365-iqdi99pd 79 18 range range NN cord-015365-iqdi99pd 79 19 , , , cord-015365-iqdi99pd 79 20 82 82 CD cord-015365-iqdi99pd 79 21 - - SYM cord-015365-iqdi99pd 79 22 510 510 CD cord-015365-iqdi99pd 79 23 ) ) -RRB- cord-015365-iqdi99pd 79 24 days day NNS cord-015365-iqdi99pd 79 25 after after IN cord-015365-iqdi99pd 79 26 HCT HCT NNP cord-015365-iqdi99pd 79 27 . . . cord-015365-iqdi99pd 80 1 Eighty eighty CD cord-015365-iqdi99pd 80 2 - - HYPH cord-015365-iqdi99pd 80 3 nine nine CD cord-015365-iqdi99pd 80 4 patients patient NNS cord-015365-iqdi99pd 80 5 ( ( -LRB- cord-015365-iqdi99pd 80 6 77 77 CD cord-015365-iqdi99pd 80 7 % % NN cord-015365-iqdi99pd 80 8 ) ) -RRB- cord-015365-iqdi99pd 80 9 had have VBD cord-015365-iqdi99pd 80 10 classic classic JJ cord-015365-iqdi99pd 80 11 cGVHD cgvhd NN cord-015365-iqdi99pd 80 12 and and CC cord-015365-iqdi99pd 80 13 26 26 CD cord-015365-iqdi99pd 80 14 ( ( -LRB- cord-015365-iqdi99pd 80 15 23 23 CD cord-015365-iqdi99pd 80 16 % % NN cord-015365-iqdi99pd 80 17 ) ) -RRB- cord-015365-iqdi99pd 81 1 overlap overlap NNP cord-015365-iqdi99pd 81 2 syndrome syndrome NN cord-015365-iqdi99pd 81 3 . . . cord-015365-iqdi99pd 82 1 Probability probability NN cord-015365-iqdi99pd 82 2 of of IN cord-015365-iqdi99pd 82 3 overall overall JJ cord-015365-iqdi99pd 82 4 survival survival NN cord-015365-iqdi99pd 82 5 ( ( -LRB- cord-015365-iqdi99pd 82 6 OS OS NNP cord-015365-iqdi99pd 82 7 ) ) -RRB- cord-015365-iqdi99pd 82 8 at at IN cord-015365-iqdi99pd 82 9 3 3 CD cord-015365-iqdi99pd 82 10 years year NNS cord-015365-iqdi99pd 82 11 for for IN cord-015365-iqdi99pd 82 12 late late JJ cord-015365-iqdi99pd 82 13 - - HYPH cord-015365-iqdi99pd 82 14 acute acute JJ cord-015365-iqdi99pd 82 15 GVHD GVHD NNP cord-015365-iqdi99pd 82 16 , , , cord-015365-iqdi99pd 82 17 chronic chronic JJ cord-015365-iqdi99pd 82 18 classic classic JJ cord-015365-iqdi99pd 82 19 and and CC cord-015365-iqdi99pd 82 20 overlap overlap VB cord-015365-iqdi99pd 82 21 cGVHD cGVHD NNP cord-015365-iqdi99pd 82 22 were be VBD cord-015365-iqdi99pd 82 23 69 69 CD cord-015365-iqdi99pd 82 24 % % NN cord-015365-iqdi99pd 82 25 , , , cord-015365-iqdi99pd 82 26 83 83 CD cord-015365-iqdi99pd 82 27 % % NN cord-015365-iqdi99pd 82 28 , , , cord-015365-iqdi99pd 82 29 and and CC cord-015365-iqdi99pd 82 30 73 73 CD cord-015365-iqdi99pd 82 31 % % NN cord-015365-iqdi99pd 82 32 . . . cord-015365-iqdi99pd 83 1 Three three CD cord-015365-iqdi99pd 83 2 - - HYPH cord-015365-iqdi99pd 83 3 year year NN cord-015365-iqdi99pd 83 4 OS os NN cord-015365-iqdi99pd 83 5 for for IN cord-015365-iqdi99pd 83 6 mild mild JJ cord-015365-iqdi99pd 83 7 , , , cord-015365-iqdi99pd 83 8 moderate moderate JJ cord-015365-iqdi99pd 83 9 and and CC cord-015365-iqdi99pd 83 10 severe severe JJ cord-015365-iqdi99pd 83 11 cGVHD cgvhd NN cord-015365-iqdi99pd 84 1 at at IN cord-015365-iqdi99pd 84 2 onset onset NN cord-015365-iqdi99pd 84 3 were be VBD cord-015365-iqdi99pd 84 4 93 93 CD cord-015365-iqdi99pd 84 5 % % NN cord-015365-iqdi99pd 84 6 , , , cord-015365-iqdi99pd 84 7 79 79 CD cord-015365-iqdi99pd 84 8 % % NN cord-015365-iqdi99pd 84 9 , , , cord-015365-iqdi99pd 84 10 and and CC cord-015365-iqdi99pd 84 11 62.5 62.5 CD cord-015365-iqdi99pd 84 12 % % NN cord-015365-iqdi99pd 84 13 and and CC cord-015365-iqdi99pd 84 14 significantly significantly RB cord-015365-iqdi99pd 84 15 different different JJ cord-015365-iqdi99pd 84 16 between between IN cord-015365-iqdi99pd 84 17 mild mild JJ cord-015365-iqdi99pd 84 18 and and CC cord-015365-iqdi99pd 84 19 severe severe JJ cord-015365-iqdi99pd 84 20 ( ( -LRB- cord-015365-iqdi99pd 84 21 p p NN cord-015365-iqdi99pd 84 22 ¼ ¼ CD cord-015365-iqdi99pd 84 23 0.007 0.007 CD cord-015365-iqdi99pd 84 24 ) ) -RRB- cord-015365-iqdi99pd 84 25 . . . cord-015365-iqdi99pd 85 1 Patients patient NNS cord-015365-iqdi99pd 85 2 with with IN cord-015365-iqdi99pd 85 3 progressive progressive JJ cord-015365-iqdi99pd 85 4 onset onset NN cord-015365-iqdi99pd 85 5 type type NN cord-015365-iqdi99pd 85 6 of of IN cord-015365-iqdi99pd 85 7 cGVHD cGVHD NNP cord-015365-iqdi99pd 85 8 had have VBD cord-015365-iqdi99pd 85 9 significantly significantly RB cord-015365-iqdi99pd 85 10 worse bad JJR cord-015365-iqdi99pd 85 11 three three CD cord-015365-iqdi99pd 85 12 - - HYPH cord-015365-iqdi99pd 85 13 year year NN cord-015365-iqdi99pd 85 14 survival survival NN cord-015365-iqdi99pd 85 15 compared compare VBN cord-015365-iqdi99pd 85 16 to to IN cord-015365-iqdi99pd 85 17 de de NNP cord-015365-iqdi99pd 85 18 novo novo NNP cord-015365-iqdi99pd 85 19 and and CC cord-015365-iqdi99pd 85 20 quiescent quiescent JJ cord-015365-iqdi99pd 85 21 ( ( -LRB- cord-015365-iqdi99pd 85 22 54.5 54.5 CD cord-015365-iqdi99pd 85 23 % % NN cord-015365-iqdi99pd 85 24 vs. vs. CC cord-015365-iqdi99pd 85 25 89.5 89.5 CD cord-015365-iqdi99pd 85 26 % % NN cord-015365-iqdi99pd 85 27 , , , cord-015365-iqdi99pd 85 28 84 84 CD cord-015365-iqdi99pd 85 29 % % NN cord-015365-iqdi99pd 85 30 , , , cord-015365-iqdi99pd 85 31 p p NN cord-015365-iqdi99pd 85 32 < < XX cord-015365-iqdi99pd 85 33 0.01 0.01 CD cord-015365-iqdi99pd 85 34 ) ) -RRB- cord-015365-iqdi99pd 85 35 . . . cord-015365-iqdi99pd 86 1 Three three CD cord-015365-iqdi99pd 86 2 - - HYPH cord-015365-iqdi99pd 86 3 year year NN cord-015365-iqdi99pd 86 4 OS OS NNP cord-015365-iqdi99pd 86 5 was be VBD cord-015365-iqdi99pd 86 6 also also RB cord-015365-iqdi99pd 86 7 significantly significantly RB cord-015365-iqdi99pd 86 8 worse bad JJR cord-015365-iqdi99pd 86 9 in in IN cord-015365-iqdi99pd 86 10 patients patient NNS cord-015365-iqdi99pd 86 11 with with IN cord-015365-iqdi99pd 86 12 platelet platelet NN cord-015365-iqdi99pd 86 13 counts count VBZ cord-015365-iqdi99pd 86 14 below below IN cord-015365-iqdi99pd 86 15 100 100 CD cord-015365-iqdi99pd 86 16 G g NN cord-015365-iqdi99pd 86 17 / / SYM cord-015365-iqdi99pd 86 18 l l NN cord-015365-iqdi99pd 86 19 at at IN cord-015365-iqdi99pd 86 20 onset onset NN cord-015365-iqdi99pd 86 21 of of IN cord-015365-iqdi99pd 86 22 cGVHD cGVHD NNP cord-015365-iqdi99pd 86 23 ( ( -LRB- cord-015365-iqdi99pd 86 24 35 35 CD cord-015365-iqdi99pd 86 25 % % NN cord-015365-iqdi99pd 86 26 vs. vs. NN cord-015365-iqdi99pd 86 27 86 86 CD cord-015365-iqdi99pd 86 28 % % NN cord-015365-iqdi99pd 86 29 , , , cord-015365-iqdi99pd 86 30 p p NN cord-015365-iqdi99pd 86 31 < < XX cord-015365-iqdi99pd 86 32 0.0001 0.0001 CD cord-015365-iqdi99pd 86 33 ) ) -RRB- cord-015365-iqdi99pd 86 34 . . . cord-015365-iqdi99pd 87 1 Conclusions conclusion NNS cord-015365-iqdi99pd 87 2 . . . cord-015365-iqdi99pd 88 1 This this DT cord-015365-iqdi99pd 88 2 prospective prospective JJ cord-015365-iqdi99pd 88 3 analysis analysis NN cord-015365-iqdi99pd 88 4 supports support VBZ cord-015365-iqdi99pd 88 5 the the DT cord-015365-iqdi99pd 88 6 importance importance NN cord-015365-iqdi99pd 88 7 of of IN cord-015365-iqdi99pd 88 8 distinguishing distinguish VBG cord-015365-iqdi99pd 88 9 late late JJ cord-015365-iqdi99pd 88 10 - - HYPH cord-015365-iqdi99pd 88 11 acute acute JJ cord-015365-iqdi99pd 88 12 GVHD GVHD NNP cord-015365-iqdi99pd 88 13 from from IN cord-015365-iqdi99pd 88 14 cGVHD cGVHD NNP cord-015365-iqdi99pd 88 15 and and CC cord-015365-iqdi99pd 88 16 indicates indicate VBZ cord-015365-iqdi99pd 88 17 a a DT cord-015365-iqdi99pd 88 18 prognostic prognostic JJ cord-015365-iqdi99pd 88 19 value value NN cord-015365-iqdi99pd 88 20 of of IN cord-015365-iqdi99pd 88 21 thrombocytopenia thrombocytopenia NN cord-015365-iqdi99pd 88 22 and and CC cord-015365-iqdi99pd 88 23 progressive progressive JJ cord-015365-iqdi99pd 88 24 onset onset NN cord-015365-iqdi99pd 88 25 type type NN cord-015365-iqdi99pd 88 26 of of IN cord-015365-iqdi99pd 88 27 cGVHD cgvhd NN cord-015365-iqdi99pd 88 28 for for IN cord-015365-iqdi99pd 88 29 HCT hct NN cord-015365-iqdi99pd 88 30 outcomes outcome NNS cord-015365-iqdi99pd 88 31 . . . cord-015365-iqdi99pd 89 1 Current current JJ cord-015365-iqdi99pd 89 2 concepts concept NNS cord-015365-iqdi99pd 89 3 suggest suggest VBP cord-015365-iqdi99pd 89 4 a a DT cord-015365-iqdi99pd 89 5 major major JJ cord-015365-iqdi99pd 89 6 role role NN cord-015365-iqdi99pd 89 7 for for IN cord-015365-iqdi99pd 89 8 innate innate JJ cord-015365-iqdi99pd 89 9 immunity immunity NN cord-015365-iqdi99pd 89 10 in in IN cord-015365-iqdi99pd 89 11 the the DT cord-015365-iqdi99pd 89 12 initiation initiation NN cord-015365-iqdi99pd 89 13 of of IN cord-015365-iqdi99pd 89 14 acute acute JJ cord-015365-iqdi99pd 89 15 graft graft NN cord-015365-iqdi99pd 89 16 - - HYPH cord-015365-iqdi99pd 89 17 vs.-host vs.-host NN cord-015365-iqdi99pd 89 18 - - HYPH cord-015365-iqdi99pd 89 19 disease disease NN cord-015365-iqdi99pd 89 20 ( ( -LRB- cord-015365-iqdi99pd 89 21 aGvHD agvhd NN cord-015365-iqdi99pd 89 22 ) ) -RRB- cord-015365-iqdi99pd 89 23 as as RB cord-015365-iqdi99pd 89 24 well well RB cord-015365-iqdi99pd 89 25 as as IN cord-015365-iqdi99pd 89 26 in in IN cord-015365-iqdi99pd 89 27 Crohn Crohn NNP cord-015365-iqdi99pd 89 28 's 's POS cord-015365-iqdi99pd 89 29 disease disease NN cord-015365-iqdi99pd 89 30 . . . cord-015365-iqdi99pd 90 1 Identical identical JJ cord-015365-iqdi99pd 90 2 single single JJ cord-015365-iqdi99pd 90 3 nucleotide nucleotide JJ cord-015365-iqdi99pd 90 4 polymorphisms polymorphism NNS cord-015365-iqdi99pd 90 5 ( ( -LRB- cord-015365-iqdi99pd 90 6 SNP SNP NNP cord-015365-iqdi99pd 90 7 ) ) -RRB- cord-015365-iqdi99pd 90 8 have have VBP cord-015365-iqdi99pd 90 9 been be VBN cord-015365-iqdi99pd 90 10 described describe VBN cord-015365-iqdi99pd 90 11 as as IN cord-015365-iqdi99pd 90 12 risk risk NN cord-015365-iqdi99pd 90 13 factors factor NNS cord-015365-iqdi99pd 90 14 for for IN cord-015365-iqdi99pd 90 15 both both DT cord-015365-iqdi99pd 90 16 diseases disease NNS cord-015365-iqdi99pd 90 17 . . . cord-015365-iqdi99pd 91 1 Recently recently RB cord-015365-iqdi99pd 91 2 , , , cord-015365-iqdi99pd 91 3 the the DT cord-015365-iqdi99pd 91 4 noncoding noncoding NNP cord-015365-iqdi99pd 91 5 C C NNP cord-015365-iqdi99pd 91 6 / / SYM cord-015365-iqdi99pd 91 7 T t NN cord-015365-iqdi99pd 91 8 polymorphism polymorphism NN cord-015365-iqdi99pd 91 9 rs2274910 rs2274910 NN cord-015365-iqdi99pd 91 10 in in IN cord-015365-iqdi99pd 91 11 intron intron NN cord-015365-iqdi99pd 91 12 3 3 CD cord-015365-iqdi99pd 91 13 of of IN cord-015365-iqdi99pd 91 14 the the DT cord-015365-iqdi99pd 91 15 intelectin intelectin NNP cord-015365-iqdi99pd 91 16 1 1 CD cord-015365-iqdi99pd 91 17 ( ( -LRB- cord-015365-iqdi99pd 91 18 ITLN1 ITLN1 NNP cord-015365-iqdi99pd 91 19 ) ) -RRB- cord-015365-iqdi99pd 91 20 gene gene NN cord-015365-iqdi99pd 91 21 ( ( -LRB- cord-015365-iqdi99pd 91 22 human human JJ cord-015365-iqdi99pd 91 23 lactoferrin lactoferrin NNP cord-015365-iqdi99pd 91 24 receptor receptor NN cord-015365-iqdi99pd 91 25 ) ) -RRB- cord-015365-iqdi99pd 91 26 has have VBZ cord-015365-iqdi99pd 91 27 been be VBN cord-015365-iqdi99pd 91 28 associated associate VBN cord-015365-iqdi99pd 91 29 with with IN cord-015365-iqdi99pd 91 30 Crohn Crohn NNP cord-015365-iqdi99pd 91 31 's 's POS cord-015365-iqdi99pd 91 32 disease disease NN cord-015365-iqdi99pd 91 33 . . . cord-015365-iqdi99pd 92 1 We -PRON- PRP cord-015365-iqdi99pd 92 2 retrospectively retrospectively RB cord-015365-iqdi99pd 92 3 typed type VBD cord-015365-iqdi99pd 92 4 this this DT cord-015365-iqdi99pd 92 5 polymorphism polymorphism NN cord-015365-iqdi99pd 92 6 in in IN cord-015365-iqdi99pd 92 7 AML AML NNP cord-015365-iqdi99pd 92 8 patients patient NNS cord-015365-iqdi99pd 92 9 and and CC cord-015365-iqdi99pd 92 10 their -PRON- PRP$ cord-015365-iqdi99pd 92 11 donors donor NNS cord-015365-iqdi99pd 92 12 . . . cord-015365-iqdi99pd 93 1 A a DT cord-015365-iqdi99pd 93 2 pilot pilot NN cord-015365-iqdi99pd 93 3 study study NN cord-015365-iqdi99pd 93 4 of of IN cord-015365-iqdi99pd 93 5 19 19 CD cord-015365-iqdi99pd 93 6 patients patient NNS cord-015365-iqdi99pd 93 7 in in IN cord-015365-iqdi99pd 93 8 CR1 CR1 NNP cord-015365-iqdi99pd 93 9 transplanted transplant VBD cord-015365-iqdi99pd 93 10 from from IN cord-015365-iqdi99pd 93 11 HLA HLA NNP cord-015365-iqdi99pd 93 12 identical identical JJ cord-015365-iqdi99pd 93 13 sibling sibling NN cord-015365-iqdi99pd 93 14 donors donor NNS cord-015365-iqdi99pd 93 15 after after IN cord-015365-iqdi99pd 93 16 myeloablative myeloablative NNP cord-015365-iqdi99pd 93 17 conditioning conditioning NNP cord-015365-iqdi99pd 93 18 was be VBD cord-015365-iqdi99pd 93 19 confirmed confirm VBN cord-015365-iqdi99pd 93 20 in in IN cord-015365-iqdi99pd 93 21 a a DT cord-015365-iqdi99pd 93 22 second second JJ cord-015365-iqdi99pd 93 23 cohort cohort NN cord-015365-iqdi99pd 93 24 including include VBG cord-015365-iqdi99pd 93 25 40 40 CD cord-015365-iqdi99pd 93 26 other other JJ cord-015365-iqdi99pd 93 27 AML AML NNP cord-015365-iqdi99pd 93 28 patients patient NNS cord-015365-iqdi99pd 93 29 . . . cord-015365-iqdi99pd 94 1 A a DT cord-015365-iqdi99pd 94 2 total total NN cord-015365-iqdi99pd 94 3 of of IN cord-015365-iqdi99pd 94 4 59 59 CD cord-015365-iqdi99pd 94 5 consecutive consecutive JJ cord-015365-iqdi99pd 94 6 patients patient NNS cord-015365-iqdi99pd 94 7 ( ( -LRB- cord-015365-iqdi99pd 94 8 median median JJ cord-015365-iqdi99pd 94 9 age age NN cord-015365-iqdi99pd 94 10 43 43 CD cord-015365-iqdi99pd 94 11 yrs yr NNS cord-015365-iqdi99pd 94 12 ( ( -LRB- cord-015365-iqdi99pd 94 13 18 18 CD cord-015365-iqdi99pd 94 14 - - SYM cord-015365-iqdi99pd 94 15 63 63 CD cord-015365-iqdi99pd 94 16 ) ) -RRB- cord-015365-iqdi99pd 94 17 ; ; : cord-015365-iqdi99pd 94 18 25/34 25/34 CD cord-015365-iqdi99pd 94 19 CR1 CR1 NNP cord-015365-iqdi99pd 94 20 / / SYM cord-015365-iqdi99pd 94 21 advanced advanced JJ cord-015365-iqdi99pd 94 22 disease disease NN cord-015365-iqdi99pd 94 23 ; ; : cord-015365-iqdi99pd 94 24 40 40 CD cord-015365-iqdi99pd 94 25 myeloablative myeloablative JJ cord-015365-iqdi99pd 94 26 and and CC cord-015365-iqdi99pd 94 27 19 19 CD cord-015365-iqdi99pd 94 28 reduced reduce VBN cord-015365-iqdi99pd 94 29 intensity intensity NN cord-015365-iqdi99pd 94 30 conditioning conditioning NN cord-015365-iqdi99pd 94 31 ; ; : cord-015365-iqdi99pd 94 32 54 54 CD cord-015365-iqdi99pd 94 33 peripheral peripheral JJ cord-015365-iqdi99pd 94 34 stem stem NN cord-015365-iqdi99pd 94 35 cells cell NNS cord-015365-iqdi99pd 94 36 ) ) -RRB- cord-015365-iqdi99pd 94 37 were be VBD cord-015365-iqdi99pd 94 38 tested test VBN cord-015365-iqdi99pd 94 39 . . . cord-015365-iqdi99pd 95 1 T T NNP cord-015365-iqdi99pd 95 2 - - HYPH cord-015365-iqdi99pd 95 3 alleles allele NNS cord-015365-iqdi99pd 95 4 were be VBD cord-015365-iqdi99pd 95 5 found find VBN cord-015365-iqdi99pd 95 6 at at IN cord-015365-iqdi99pd 95 7 a a DT cord-015365-iqdi99pd 95 8 frequency frequency NN cord-015365-iqdi99pd 95 9 of of IN cord-015365-iqdi99pd 95 10 28.8 28.8 CD cord-015365-iqdi99pd 95 11 % % NN cord-015365-iqdi99pd 95 12 in in IN cord-015365-iqdi99pd 95 13 recipients recipient NNS cord-015365-iqdi99pd 95 14 and and CC cord-015365-iqdi99pd 95 15 29.7 29.7 CD cord-015365-iqdi99pd 95 16 % % NN cord-015365-iqdi99pd 95 17 in in IN cord-015365-iqdi99pd 95 18 donors donor NNS cord-015365-iqdi99pd 95 19 . . . cord-015365-iqdi99pd 96 1 50.8 50.8 CD cord-015365-iqdi99pd 96 2 % % NN cord-015365-iqdi99pd 96 3 of of IN cord-015365-iqdi99pd 96 4 patients patient NNS cord-015365-iqdi99pd 96 5 had have VBD cord-015365-iqdi99pd 96 6 a a DT cord-015365-iqdi99pd 96 7 CC CC NNP cord-015365-iqdi99pd 96 8 genotype genotype NN cord-015365-iqdi99pd 96 9 . . . cord-015365-iqdi99pd 97 1 In in IN cord-015365-iqdi99pd 97 2 the the DT cord-015365-iqdi99pd 97 3 pilot pilot NN cord-015365-iqdi99pd 97 4 study study NN cord-015365-iqdi99pd 97 5 , , , cord-015365-iqdi99pd 97 6 2 2 CD cord-015365-iqdi99pd 97 7 out out IN cord-015365-iqdi99pd 97 8 of of IN cord-015365-iqdi99pd 97 9 12 12 CD cord-015365-iqdi99pd 97 10 patients patient NNS cord-015365-iqdi99pd 97 11 with with IN cord-015365-iqdi99pd 97 12 a a DT cord-015365-iqdi99pd 97 13 CC cc NN cord-015365-iqdi99pd 97 14 genotype genotype NN cord-015365-iqdi99pd 97 15 versus versus IN cord-015365-iqdi99pd 97 16 5 5 CD cord-015365-iqdi99pd 97 17 out out IN cord-015365-iqdi99pd 97 18 of of IN cord-015365-iqdi99pd 97 19 7 7 CD cord-015365-iqdi99pd 97 20 patients patient NNS cord-015365-iqdi99pd 97 21 with with IN cord-015365-iqdi99pd 97 22 a a DT cord-015365-iqdi99pd 97 23 T t NN cord-015365-iqdi99pd 97 24 - - HYPH cord-015365-iqdi99pd 97 25 allele allele NN cord-015365-iqdi99pd 97 26 had have VBD cord-015365-iqdi99pd 97 27 acute acute JJ cord-015365-iqdi99pd 97 28 intestinal intestinal JJ cord-015365-iqdi99pd 97 29 aGvHD aGvHD . cord-015365-iqdi99pd 97 30 ( ( -LRB- cord-015365-iqdi99pd 97 31 p p NN cord-015365-iqdi99pd 97 32 ¼ ¼ NNP cord-015365-iqdi99pd 97 33 0.045 0.045 CD cord-015365-iqdi99pd 97 34 ) ) -RRB- cord-015365-iqdi99pd 97 35 . . . cord-015365-iqdi99pd 98 1 These these DT cord-015365-iqdi99pd 98 2 results result NNS cord-015365-iqdi99pd 98 3 were be VBD cord-015365-iqdi99pd 98 4 confirmed confirm VBN cord-015365-iqdi99pd 98 5 in in IN cord-015365-iqdi99pd 98 6 a a DT cord-015365-iqdi99pd 98 7 second second JJ cord-015365-iqdi99pd 98 8 cohort cohort NN cord-015365-iqdi99pd 98 9 . . . cord-015365-iqdi99pd 99 1 Acute acute JJ cord-015365-iqdi99pd 99 2 intestinal intestinal JJ cord-015365-iqdi99pd 99 3 GvHD gvhd NN cord-015365-iqdi99pd 99 4 was be VBD cord-015365-iqdi99pd 99 5 found find VBN cord-015365-iqdi99pd 99 6 in in IN cord-015365-iqdi99pd 99 7 3/18 3/18 CD cord-015365-iqdi99pd 99 8 patients patient NNS cord-015365-iqdi99pd 99 9 ( ( -LRB- cord-015365-iqdi99pd 99 10 16.7 16.7 CD cord-015365-iqdi99pd 99 11 % % NN cord-015365-iqdi99pd 99 12 ) ) -RRB- cord-015365-iqdi99pd 99 13 with with IN cord-015365-iqdi99pd 99 14 a a DT cord-015365-iqdi99pd 99 15 CC cc NN cord-015365-iqdi99pd 99 16 genotype genotype NN cord-015365-iqdi99pd 99 17 and and CC cord-015365-iqdi99pd 99 18 12/ 12/ CD cord-015365-iqdi99pd 99 19 22 22 CD cord-015365-iqdi99pd 99 20 patients patient NNS cord-015365-iqdi99pd 99 21 ( ( -LRB- cord-015365-iqdi99pd 99 22 54.5 54.5 CD cord-015365-iqdi99pd 99 23 % % NN cord-015365-iqdi99pd 99 24 ) ) -RRB- cord-015365-iqdi99pd 99 25 with with IN cord-015365-iqdi99pd 99 26 a a DT cord-015365-iqdi99pd 99 27 T t NN cord-015365-iqdi99pd 99 28 - - HYPH cord-015365-iqdi99pd 99 29 allele allele NN cord-015365-iqdi99pd 99 30 ( ( -LRB- cord-015365-iqdi99pd 99 31 p p NN cord-015365-iqdi99pd 99 32 ¼ ¼ CD cord-015365-iqdi99pd 99 33 0.014 0.014 CD cord-015365-iqdi99pd 99 34 ) ) -RRB- cord-015365-iqdi99pd 99 35 . . . cord-015365-iqdi99pd 100 1 In in IN cord-015365-iqdi99pd 100 2 a a DT cord-015365-iqdi99pd 100 3 combined combined JJ cord-015365-iqdi99pd 100 4 analysis analysis NN cord-015365-iqdi99pd 100 5 ( ( -LRB- cord-015365-iqdi99pd 100 6 n n NN cord-015365-iqdi99pd 100 7 ¼ ¼ NNP cord-015365-iqdi99pd 100 8 59 59 CD cord-015365-iqdi99pd 100 9 ) ) -RRB- cord-015365-iqdi99pd 100 10 we -PRON- PRP cord-015365-iqdi99pd 100 11 found find VBD cord-015365-iqdi99pd 100 12 intestinal intestinal JJ cord-015365-iqdi99pd 100 13 aGvHD agvhd NN cord-015365-iqdi99pd 100 14 in in IN cord-015365-iqdi99pd 100 15 58.6 58.6 CD cord-015365-iqdi99pd 100 16 % % NN cord-015365-iqdi99pd 100 17 of of IN cord-015365-iqdi99pd 100 18 patients patient NNS cord-015365-iqdi99pd 100 19 with with IN cord-015365-iqdi99pd 100 20 a a DT cord-015365-iqdi99pd 100 21 T t NN cord-015365-iqdi99pd 100 22 - - HYPH cord-015365-iqdi99pd 100 23 allele allele NN cord-015365-iqdi99pd 100 24 versus versus IN cord-015365-iqdi99pd 100 25 16.7 16.7 CD cord-015365-iqdi99pd 100 26 % % NN cord-015365-iqdi99pd 100 27 of of IN cord-015365-iqdi99pd 100 28 patients patient NNS cord-015365-iqdi99pd 100 29 with with IN cord-015365-iqdi99pd 100 30 a a DT cord-015365-iqdi99pd 100 31 CC cc NN cord-015365-iqdi99pd 100 32 genotype genotype NN cord-015365-iqdi99pd 100 33 ( ( -LRB- cord-015365-iqdi99pd 100 34 p p NN cord-015365-iqdi99pd 100 35 < < XX cord-015365-iqdi99pd 100 36 0.001 0.001 CD cord-015365-iqdi99pd 100 37 ) ) -RRB- cord-015365-iqdi99pd 100 38 . . . cord-015365-iqdi99pd 101 1 The the DT cord-015365-iqdi99pd 101 2 lower low JJR cord-015365-iqdi99pd 101 3 incidence incidence NN cord-015365-iqdi99pd 101 4 of of IN cord-015365-iqdi99pd 101 5 aGvHD agvhd NN cord-015365-iqdi99pd 101 6 grades grade NNS cord-015365-iqdi99pd 101 7 II II NNP cord-015365-iqdi99pd 101 8 - - HYPH cord-015365-iqdi99pd 101 9 IV IV NNP cord-015365-iqdi99pd 101 10 in in IN cord-015365-iqdi99pd 101 11 patients patient NNS cord-015365-iqdi99pd 101 12 with with IN cord-015365-iqdi99pd 101 13 a a DT cord-015365-iqdi99pd 101 14 CC cc NN cord-015365-iqdi99pd 101 15 genotype genotype NN cord-015365-iqdi99pd 101 16 ( ( -LRB- cord-015365-iqdi99pd 101 17 p p NN cord-015365-iqdi99pd 101 18 ¼ ¼ NNP cord-015365-iqdi99pd 101 19 0.019 0.019 CD cord-015365-iqdi99pd 101 20 ) ) -RRB- cord-015365-iqdi99pd 101 21 was be VBD cord-015365-iqdi99pd 101 22 only only RB cord-015365-iqdi99pd 101 23 due due JJ cord-015365-iqdi99pd 101 24 to to IN cord-015365-iqdi99pd 101 25 less less RBR cord-015365-iqdi99pd 101 26 intestinal intestinal JJ cord-015365-iqdi99pd 101 27 aGvHD agvhd NN cord-015365-iqdi99pd 101 28 while while IN cord-015365-iqdi99pd 101 29 no no DT cord-015365-iqdi99pd 101 30 difference difference NN cord-015365-iqdi99pd 101 31 was be VBD cord-015365-iqdi99pd 101 32 found find VBN cord-015365-iqdi99pd 101 33 with with IN cord-015365-iqdi99pd 101 34 regard regard NN cord-015365-iqdi99pd 101 35 to to IN cord-015365-iqdi99pd 101 36 skin skin NN cord-015365-iqdi99pd 101 37 or or CC cord-015365-iqdi99pd 101 38 liver liver NN cord-015365-iqdi99pd 101 39 aGvHD agvhd NN cord-015365-iqdi99pd 101 40 . . . cord-015365-iqdi99pd 102 1 We -PRON- PRP cord-015365-iqdi99pd 102 2 did do VBD cord-015365-iqdi99pd 102 3 not not RB cord-015365-iqdi99pd 102 4 see see VB cord-015365-iqdi99pd 102 5 any any DT cord-015365-iqdi99pd 102 6 association association NN cord-015365-iqdi99pd 102 7 between between IN cord-015365-iqdi99pd 102 8 donor donor NN cord-015365-iqdi99pd 102 9 genotypes genotype NNS cord-015365-iqdi99pd 102 10 and and CC cord-015365-iqdi99pd 102 11 aGvHD agvhd NN cord-015365-iqdi99pd 102 12 . . . cord-015365-iqdi99pd 103 1 The the DT cord-015365-iqdi99pd 103 2 strong strong JJ cord-015365-iqdi99pd 103 3 association association NN cord-015365-iqdi99pd 103 4 ( ( -LRB- cord-015365-iqdi99pd 103 5 RR RR NNP cord-015365-iqdi99pd 103 6 3.52 3.52 CD cord-015365-iqdi99pd 103 7 ; ; : cord-015365-iqdi99pd 103 8 95 95 CD cord-015365-iqdi99pd 103 9 % % NN cord-015365-iqdi99pd 103 10 CI CI NNP cord-015365-iqdi99pd 103 11 1.5 1.5 CD cord-015365-iqdi99pd 103 12 - - HYPH cord-015365-iqdi99pd 103 13 8.2 8.2 CD cord-015365-iqdi99pd 103 14 ) ) -RRB- cord-015365-iqdi99pd 103 15 between between IN cord-015365-iqdi99pd 103 16 this this DT cord-015365-iqdi99pd 103 17 SNP SNP NNP cord-015365-iqdi99pd 103 18 and and CC cord-015365-iqdi99pd 103 19 the the DT cord-015365-iqdi99pd 103 20 incidence incidence NN cord-015365-iqdi99pd 103 21 of of IN cord-015365-iqdi99pd 103 22 intestinal intestinal JJ cord-015365-iqdi99pd 103 23 aGvHD agvhd NN cord-015365-iqdi99pd 103 24 is be VBZ cord-015365-iqdi99pd 103 25 in in IN cord-015365-iqdi99pd 103 26 accordance accordance NN cord-015365-iqdi99pd 103 27 with with IN cord-015365-iqdi99pd 103 28 reports report NNS cord-015365-iqdi99pd 103 29 about about IN cord-015365-iqdi99pd 103 30 SNPs SNPs NNPS cord-015365-iqdi99pd 103 31 in in IN cord-015365-iqdi99pd 103 32 other other JJ cord-015365-iqdi99pd 103 33 genes gene NNS cord-015365-iqdi99pd 103 34 associated associate VBN cord-015365-iqdi99pd 103 35 with with IN cord-015365-iqdi99pd 103 36 both both DT cord-015365-iqdi99pd 103 37 aGvHD agvhd NN cord-015365-iqdi99pd 103 38 and and CC cord-015365-iqdi99pd 103 39 Crohn Crohn NNP cord-015365-iqdi99pd 103 40 's 's POS cord-015365-iqdi99pd 103 41 disease disease NN cord-015365-iqdi99pd 103 42 . . . cord-015365-iqdi99pd 104 1 Our -PRON- PRP$ cord-015365-iqdi99pd 104 2 results result NNS cord-015365-iqdi99pd 104 3 further further RB cord-015365-iqdi99pd 104 4 support support VBP cord-015365-iqdi99pd 104 5 the the DT cord-015365-iqdi99pd 104 6 concept concept NN cord-015365-iqdi99pd 104 7 of of IN cord-015365-iqdi99pd 104 8 the the DT cord-015365-iqdi99pd 104 9 importance importance NN cord-015365-iqdi99pd 104 10 of of IN cord-015365-iqdi99pd 104 11 the the DT cord-015365-iqdi99pd 104 12 gut gut NN cord-015365-iqdi99pd 104 13 associated associate VBN cord-015365-iqdi99pd 104 14 innate innate JJ cord-015365-iqdi99pd 104 15 immune immune JJ cord-015365-iqdi99pd 104 16 system system NN cord-015365-iqdi99pd 104 17 in in IN cord-015365-iqdi99pd 104 18 the the DT cord-015365-iqdi99pd 104 19 initiation initiation NN cord-015365-iqdi99pd 104 20 of of IN cord-015365-iqdi99pd 104 21 aGvHD agvhd NN cord-015365-iqdi99pd 104 22 . . . cord-015365-iqdi99pd 105 1 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 105 2 . . . cord-015365-iqdi99pd 106 1 Klinische Klinische NNP cord-015365-iqdi99pd 106 2 Studien Studien NNP cord-015365-iqdi99pd 106 3 zeigen zeigen NNP cord-015365-iqdi99pd 106 4 , , , cord-015365-iqdi99pd 106 5 dass dass NNP cord-015365-iqdi99pd 106 6 sich sich NNP cord-015365-iqdi99pd 106 7 Minorhistokompatibilitätsantigen Minorhistokompatibilitätsantigen NNP cord-015365-iqdi99pd 106 8 ( ( -LRB- cord-015365-iqdi99pd 106 9 mHag)-spezifische mHag)-spezifische `` cord-015365-iqdi99pd 106 10 Spender Spender NNP cord-015365-iqdi99pd 106 11 T T NNP cord-015365-iqdi99pd 106 12 - - HYPH cord-015365-iqdi99pd 106 13 Zellen Zellen NNP cord-015365-iqdi99pd 106 14 positiv positiv JJ cord-015365-iqdi99pd 106 15 in in IN cord-015365-iqdi99pd 106 16 der der NNP cord-015365-iqdi99pd 106 17 Therapie Therapie NNP cord-015365-iqdi99pd 106 18 eines eine NNS cord-015365-iqdi99pd 107 1 leukämischen leukämischen NNP cord-015365-iqdi99pd 107 2 Relapses Relapses NNP cord-015365-iqdi99pd 107 3 nach nach VBP cord-015365-iqdi99pd 107 4 HLAidenter HLAidenter NNP cord-015365-iqdi99pd 108 1 hämatopoetischer hämatopoetischer NNP cord-015365-iqdi99pd 108 2 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 108 3 ( ( -LRB- cord-015365-iqdi99pd 108 4 SZT SZT NNP cord-015365-iqdi99pd 108 5 ) ) -RRB- cord-015365-iqdi99pd 108 6 auswirken auswirken VBN cord-015365-iqdi99pd 108 7 . . . cord-015365-iqdi99pd 109 1 Der Der NNP cord-015365-iqdi99pd 109 2 prädiktive prädiktive NNP cord-015365-iqdi99pd 110 1 Wert wert UH cord-015365-iqdi99pd 110 2 der der NNP cord-015365-iqdi99pd 110 3 mHag mHag NNP cord-015365-iqdi99pd 110 4 - - HYPH cord-015365-iqdi99pd 110 5 Typisierung Typisierung NNP cord-015365-iqdi99pd 110 6 für für IN cord-015365-iqdi99pd 110 7 das das NNP cord-015365-iqdi99pd 110 8 Auftreten Auftreten NNP cord-015365-iqdi99pd 110 9 eines eines NNP cord-015365-iqdi99pd 110 10 Graft graft NN cord-015365-iqdi99pd 110 11 - - HYPH cord-015365-iqdi99pd 110 12 versus versus NN cord-015365-iqdi99pd 110 13 - - HYPH cord-015365-iqdi99pd 110 14 Leukämie Leukämie NNP cord-015365-iqdi99pd 110 15 Effektes Effektes NNP cord-015365-iqdi99pd 111 1 oder oder NNP cord-015365-iqdi99pd 111 2 von von NNP cord-015365-iqdi99pd 111 3 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 111 4 nach nach NNP cord-015365-iqdi99pd 111 5 SZT SZT NNP cord-015365-iqdi99pd 111 6 ist ist FW cord-015365-iqdi99pd 111 7 jedoch jedoch NN cord-015365-iqdi99pd 111 8 nach nach NN cord-015365-iqdi99pd 111 9 wie wie NN cord-015365-iqdi99pd 111 10 vor vor NNP cord-015365-iqdi99pd 111 11 umstritten umstritten NNP cord-015365-iqdi99pd 111 12 . . . cord-015365-iqdi99pd 112 1 Auch Auch NNP cord-015365-iqdi99pd 112 2 Langzeitstudien Langzeitstudien NNP cord-015365-iqdi99pd 113 1 über über NNP cord-015365-iqdi99pd 113 2 den den NNP cord-015365-iqdi99pd 113 3 Einfluss Einfluss NNP cord-015365-iqdi99pd 113 4 von von NNP cord-015365-iqdi99pd 113 5 mHag mHag NNP cord-015365-iqdi99pd 113 6 - - HYPH cord-015365-iqdi99pd 113 7 Mismatches mismatch NNS cord-015365-iqdi99pd 113 8 auf auf NNP cord-015365-iqdi99pd 113 9 das das NNP cord-015365-iqdi99pd 113 10 Ü ü NN cord-015365-iqdi99pd 113 11 berleben berleben NNP cord-015365-iqdi99pd 113 12 der der NNP cord-015365-iqdi99pd 113 13 Patienten Patienten NNP cord-015365-iqdi99pd 113 14 fehlen fehlen XX cord-015365-iqdi99pd 113 15 . . . cord-015365-iqdi99pd 114 1 Deshalb Deshalb NNP cord-015365-iqdi99pd 114 2 haben haben NNP cord-015365-iqdi99pd 114 3 wir wir NNP cord-015365-iqdi99pd 114 4 in in IN cord-015365-iqdi99pd 114 5 der der NNP cord-015365-iqdi99pd 114 6 vorliegenden vorliegenden NNP cord-015365-iqdi99pd 114 7 Studie Studie NNP cord-015365-iqdi99pd 114 8 Unterschiede Unterschiede NNP cord-015365-iqdi99pd 114 9 in in IN cord-015365-iqdi99pd 114 10 zehn zehn NNP cord-015365-iqdi99pd 114 11 verschiedenen verschiedenen NNP cord-015365-iqdi99pd 114 12 mHag mHag VBZ cord-015365-iqdi99pd 114 13 in in IN cord-015365-iqdi99pd 114 14 insgesamt insgesamt NNP cord-015365-iqdi99pd 114 15 217 217 CD cord-015365-iqdi99pd 114 16 Patienten Patienten NNP cord-015365-iqdi99pd 115 1 und und IN cord-015365-iqdi99pd 115 2 ihren ihren NNP cord-015365-iqdi99pd 116 1 HLA HLA NNP cord-015365-iqdi99pd 116 2 - - HYPH cord-015365-iqdi99pd 116 3 identen identen NNP cord-015365-iqdi99pd 116 4 Familienoder Familienoder NNP cord-015365-iqdi99pd 116 5 Fremdspendern Fremdspendern NNP cord-015365-iqdi99pd 116 6 untersucht untersucht NN cord-015365-iqdi99pd 116 7 und und NNP cord-015365-iqdi99pd 116 8 sie sie NNP cord-015365-iqdi99pd 116 9 mit mit NNP cord-015365-iqdi99pd 116 10 Ü Ü NNP cord-015365-iqdi99pd 116 11 berleben berleben NNP cord-015365-iqdi99pd 116 12 und und DT cord-015365-iqdi99pd 116 13 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 116 14 nach nach NN cord-015365-iqdi99pd 116 15 allogener allogener JJ cord-015365-iqdi99pd 116 16 SZT SZT NNP cord-015365-iqdi99pd 116 17 korreliert korreliert NNP cord-015365-iqdi99pd 116 18 . . . cord-015365-iqdi99pd 117 1 Methodik Methodik NNP cord-015365-iqdi99pd 117 2 . . . cord-015365-iqdi99pd 118 1 Die die VB cord-015365-iqdi99pd 118 2 Bestimmung Bestimmung NNP cord-015365-iqdi99pd 118 3 der der NNP cord-015365-iqdi99pd 118 4 mHag mHag NNP cord-015365-iqdi99pd 118 5 wurde wurde NN cord-015365-iqdi99pd 118 6 mittels mittels NNP cord-015365-iqdi99pd 118 7 Allelspezifischer Allelspezifischer NNP cord-015365-iqdi99pd 118 8 Polymerase Polymerase NNP cord-015365-iqdi99pd 118 9 - - HYPH cord-015365-iqdi99pd 118 10 Kettenreaktion Kettenreaktion NNP cord-015365-iqdi99pd 118 11 mit mit NNP cord-015365-iqdi99pd 118 12 Hilfe Hilfe NNP cord-015365-iqdi99pd 118 13 eines eine NNS cord-015365-iqdi99pd 118 14 kommerziell kommerziell NNP cord-015365-iqdi99pd 118 15 erhältlichen erhältlichen NNP cord-015365-iqdi99pd 118 16 mHag mHag NNP cord-015365-iqdi99pd 118 17 - - HYPH cord-015365-iqdi99pd 118 18 Typisierungskits Typisierungskits NNP cord-015365-iqdi99pd 118 19 durchgeführt durchgeführt NN cord-015365-iqdi99pd 118 20 . . . cord-015365-iqdi99pd 119 1 Die die VB cord-015365-iqdi99pd 119 2 Wahrscheinlichkeit Wahrscheinlichkeit NNP cord-015365-iqdi99pd 119 3 des des NNP cord-015365-iqdi99pd 119 4 Ü ü NN cord-015365-iqdi99pd 119 5 berlebens berlebens NNP cord-015365-iqdi99pd 120 1 ( ( -LRB- cord-015365-iqdi99pd 120 2 bis bis NNP cord-015365-iqdi99pd 120 3 zu zu NNP cord-015365-iqdi99pd 120 4 22 22 CD cord-015365-iqdi99pd 121 1 Jahre Jahre NNP cord-015365-iqdi99pd 121 2 nach nach NNP cord-015365-iqdi99pd 121 3 SZT SZT NNP cord-015365-iqdi99pd 121 4 ) ) -RRB- cord-015365-iqdi99pd 122 1 wurde wurde NNP cord-015365-iqdi99pd 122 2 mittels mittels NNP cord-015365-iqdi99pd 122 3 Kaplan Kaplan NNP cord-015365-iqdi99pd 122 4 - - HYPH cord-015365-iqdi99pd 122 5 Meier Meier NNP cord-015365-iqdi99pd 122 6 Ü Ü NNP cord-015365-iqdi99pd 122 7 berlebensanalyse berlebensanalyse NNP cord-015365-iqdi99pd 122 8 , , , cord-015365-iqdi99pd 122 9 die die VB cord-015365-iqdi99pd 122 10 Komplikationsraten Komplikationsraten NNP cord-015365-iqdi99pd 122 11 mittels mittel NNS cord-015365-iqdi99pd 122 12 Cumulativer Cumulativer NNP cord-015365-iqdi99pd 122 13 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 122 14 berechnet berechnet NN cord-015365-iqdi99pd 122 15 . . . cord-015365-iqdi99pd 123 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 123 2 . . . cord-015365-iqdi99pd 124 1 Von Von NNP cord-015365-iqdi99pd 124 2 den den NNP cord-015365-iqdi99pd 124 3 217 217 CD cord-015365-iqdi99pd 125 1 Patienten Patienten NNP cord-015365-iqdi99pd 125 2 / / SYM cord-015365-iqdi99pd 125 3 Spenderkombinationen Spenderkombinationen NNP cord-015365-iqdi99pd 125 4 wiesen wiesen VBD cord-015365-iqdi99pd 125 5 119 119 CD cord-015365-iqdi99pd 125 6 keinen keinen NNP cord-015365-iqdi99pd 125 7 mHag mHag NNP cord-015365-iqdi99pd 125 8 - - HYPH cord-015365-iqdi99pd 125 9 Mismatch mismatch NN cord-015365-iqdi99pd 125 10 , , , cord-015365-iqdi99pd 125 11 67 67 CD cord-015365-iqdi99pd 125 12 einen einen NNP cord-015365-iqdi99pd 125 13 mHag mHag NNP cord-015365-iqdi99pd 125 14 - - HYPH cord-015365-iqdi99pd 125 15 Mismatch mismatch NN cord-015365-iqdi99pd 125 16 und und XX cord-015365-iqdi99pd 126 1 31 31 CD cord-015365-iqdi99pd 126 2 zwei zwei NNP cord-015365-iqdi99pd 126 3 oder oder NNP cord-015365-iqdi99pd 126 4 mehrere mehrere NNP cord-015365-iqdi99pd 126 5 mHag mHag NNP cord-015365-iqdi99pd 126 6 - - HYPH cord-015365-iqdi99pd 126 7 Mismatches mismatch NNS cord-015365-iqdi99pd 126 8 auf auf NNS cord-015365-iqdi99pd 126 9 . . . cord-015365-iqdi99pd 127 1 Sämtliche Sämtliche NNP cord-015365-iqdi99pd 127 2 Patienten Patienten NNP cord-015365-iqdi99pd 127 3 mit mit XX cord-015365-iqdi99pd 128 1 einem einem NNP cord-015365-iqdi99pd 128 2 HA-1- HA-1- NNP cord-015365-iqdi99pd 128 3 , , , cord-015365-iqdi99pd 128 4 HA-2- HA-2- NNP cord-015365-iqdi99pd 128 5 , , , cord-015365-iqdi99pd 128 6 HA-8-(HLA HA-8-(HLA NNP cord-015365-iqdi99pd 128 7 - - HYPH cord-015365-iqdi99pd 128 8 A2-restringiert a2-restringiert JJ cord-015365-iqdi99pd 128 9 ) ) -RRB- cord-015365-iqdi99pd 129 1 oder oder NNP cord-015365-iqdi99pd 129 2 HA-3-(HLA HA-3-(HLA NNP cord-015365-iqdi99pd 129 3 - - HYPH cord-015365-iqdi99pd 129 4 A1-restringiert A1-restringiert NNP cord-015365-iqdi99pd 129 5 ) ) -RRB- cord-015365-iqdi99pd 130 1 Mismatch mismatch NN cord-015365-iqdi99pd 130 2 zeigten zeigten NNP cord-015365-iqdi99pd 131 1 eine eine NNP cord-015365-iqdi99pd 131 2 geringere geringere NNP cord-015365-iqdi99pd 131 3 Rezidivrate Rezidivrate NNP cord-015365-iqdi99pd 131 4 als als NNP cord-015365-iqdi99pd 131 5 Patienten Patienten NNP cord-015365-iqdi99pd 131 6 ohne ohne NNP cord-015365-iqdi99pd 131 7 den den NNP cord-015365-iqdi99pd 131 8 entsprechenden entsprechenden NNP cord-015365-iqdi99pd 131 9 mHag mHag NNP cord-015365-iqdi99pd 131 10 - - HYPH cord-015365-iqdi99pd 131 11 Mismatch mismatch NN cord-015365-iqdi99pd 131 12 . . . cord-015365-iqdi99pd 132 1 Ein Ein NNP cord-015365-iqdi99pd 132 2 HA-2-und HA-2-und NNP cord-015365-iqdi99pd 132 3 ein ein NN cord-015365-iqdi99pd 133 1 HA-3-Mismatch HA-3-Mismatch NNP cord-015365-iqdi99pd 133 2 waren waren NNP cord-015365-iqdi99pd 133 3 jedoch jedoch NNP cord-015365-iqdi99pd 134 1 mit mit NNP cord-015365-iqdi99pd 134 2 einer einer NNP cord-015365-iqdi99pd 134 3 erhöhten erhöhten VBN cord-015365-iqdi99pd 134 4 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 135 1 an an DT cord-015365-iqdi99pd 135 2 akuter akuter NN cord-015365-iqdi99pd 135 3 GvHD GvHD NNP cord-015365-iqdi99pd 135 4 und und IN cord-015365-iqdi99pd 136 1 daher daher NNP cord-015365-iqdi99pd 136 2 mit mit NNP cord-015365-iqdi99pd 136 3 einer einer NNP cord-015365-iqdi99pd 136 4 geringeren geringeren NNP cord-015365-iqdi99pd 136 5 Ü Ü NNP cord-015365-iqdi99pd 136 6 berlebensrate berlebensrate NNP cord-015365-iqdi99pd 136 7 verbunden verbunden NNP cord-015365-iqdi99pd 136 8 . . . cord-015365-iqdi99pd 137 1 Patienten Patienten NNP cord-015365-iqdi99pd 137 2 / / , cord-015365-iqdi99pd 137 3 Spenderkombinationen Spenderkombinationen NNP cord-015365-iqdi99pd 137 4 mit mit NNP cord-015365-iqdi99pd 138 1 einem einem NNP cord-015365-iqdi99pd 138 2 HY HY NNP cord-015365-iqdi99pd 138 3 - - HYPH cord-015365-iqdi99pd 138 4 Mismatch Mismatch NNP cord-015365-iqdi99pd 138 5 profitierten profitierten NNP cord-015365-iqdi99pd 138 6 mit mit NNP cord-015365-iqdi99pd 138 7 einem einem NNP cord-015365-iqdi99pd 138 8 leichten leichten NNP cord-015365-iqdi99pd 138 9 Ü Ü NNP cord-015365-iqdi99pd 138 10 berlebensvorteil berlebensvorteil NNP cord-015365-iqdi99pd 138 11 ( ( -LRB- cord-015365-iqdi99pd 138 12 48 48 CD cord-015365-iqdi99pd 138 13 % % NN cord-015365-iqdi99pd 138 14 vs. vs. IN cord-015365-iqdi99pd 138 15 40 40 CD cord-015365-iqdi99pd 138 16 % % NN cord-015365-iqdi99pd 138 17 ) ) -RRB- cord-015365-iqdi99pd 138 18 . . . cord-015365-iqdi99pd 139 1 Interessanterweise Interessanterweise NNP cord-015365-iqdi99pd 139 2 wirkten wirkten NN cord-015365-iqdi99pd 139 3 sich sich NNP cord-015365-iqdi99pd 139 4 mehrere mehrere NNP cord-015365-iqdi99pd 139 5 mHag mHag NNP cord-015365-iqdi99pd 139 6 - - HYPH cord-015365-iqdi99pd 139 7 Mismatches mismatch NNS cord-015365-iqdi99pd 139 8 positiv positiv JJ cord-015365-iqdi99pd 139 9 auf auf NNS cord-015365-iqdi99pd 139 10 das das NNP cord-015365-iqdi99pd 139 11 Langzeitüberleben Langzeitüberleben NNP cord-015365-iqdi99pd 139 12 aus aus NNP cord-015365-iqdi99pd 139 13 . . . cord-015365-iqdi99pd 140 1 Vier Vier NNP cord-015365-iqdi99pd 140 2 Jahre Jahre NNP cord-015365-iqdi99pd 140 3 nach nach NN cord-015365-iqdi99pd 140 4 SZT SZT NNP cord-015365-iqdi99pd 140 5 betrug betrug NNP cord-015365-iqdi99pd 140 6 das das NNP cord-015365-iqdi99pd 140 7 Gesamtüberleben Gesamtüberleben NNP cord-015365-iqdi99pd 140 8 von von NNP cord-015365-iqdi99pd 140 9 Patienten Patienten NNP cord-015365-iqdi99pd 140 10 ohne ohne NNP cord-015365-iqdi99pd 140 11 Mismatch Mismatch NNP cord-015365-iqdi99pd 140 12 44 44 CD cord-015365-iqdi99pd 140 13 % % NN cord-015365-iqdi99pd 140 14 , , , cord-015365-iqdi99pd 140 15 von von NNP cord-015365-iqdi99pd 140 16 Patienten Patienten NNP cord-015365-iqdi99pd 140 17 mit mit NNP cord-015365-iqdi99pd 140 18 einem einem NNP cord-015365-iqdi99pd 140 19 Mismatch Mismatch NNP cord-015365-iqdi99pd 140 20 43 43 CD cord-015365-iqdi99pd 140 21 % % NN cord-015365-iqdi99pd 140 22 , , , cord-015365-iqdi99pd 141 1 von von NNP cord-015365-iqdi99pd 141 2 Patienten Patienten NNP cord-015365-iqdi99pd 141 3 mit mit NNP cord-015365-iqdi99pd 141 4 2 2 CD cord-015365-iqdi99pd 141 5 Mismatches mismatch NNS cord-015365-iqdi99pd 141 6 55 55 CD cord-015365-iqdi99pd 141 7 % % NN cord-015365-iqdi99pd 142 1 und und NNP cord-015365-iqdi99pd 143 1 von von NNP cord-015365-iqdi99pd 143 2 Patienten Patienten NNP cord-015365-iqdi99pd 143 3 mit mit NNP cord-015365-iqdi99pd 143 4 3 3 CD cord-015365-iqdi99pd 143 5 Mismatches mismatch NNS cord-015365-iqdi99pd 143 6 75 75 CD cord-015365-iqdi99pd 143 7 % % NN cord-015365-iqdi99pd 144 1 ( ( -LRB- cord-015365-iqdi99pd 144 2 allerdings allerdings NNP cord-015365-iqdi99pd 144 3 nur nur NNP cord-015365-iqdi99pd 144 4 8 8 CD cord-015365-iqdi99pd 144 5 Patienten Patienten NNP cord-015365-iqdi99pd 144 6 ) ) -RRB- cord-015365-iqdi99pd 144 7 . . . cord-015365-iqdi99pd 145 1 In in IN cord-015365-iqdi99pd 145 2 Ü Ü NNP cord-015365-iqdi99pd 145 3 bereinstimmung bereinstimmung NNP cord-015365-iqdi99pd 145 4 mit mit NNP cord-015365-iqdi99pd 145 5 diesem diesem NNP cord-015365-iqdi99pd 145 6 Ergebnis Ergebnis NNP cord-015365-iqdi99pd 145 7 betrug betrug NNP cord-015365-iqdi99pd 145 8 die die VB cord-015365-iqdi99pd 145 9 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 145 10 der der NNP cord-015365-iqdi99pd 145 11 Nonrelapse Nonrelapse NNP cord-015365-iqdi99pd 146 1 -Mortalität -Mortalität : cord-015365-iqdi99pd 146 2 von von NNP cord-015365-iqdi99pd 146 3 Patienten Patienten NNP cord-015365-iqdi99pd 146 4 ohne ohne NNP cord-015365-iqdi99pd 146 5 Mismatch Mismatch NNP cord-015365-iqdi99pd 146 6 50 50 CD cord-015365-iqdi99pd 146 7 % % NN cord-015365-iqdi99pd 146 8 , , , cord-015365-iqdi99pd 146 9 von von NNP cord-015365-iqdi99pd 146 10 Patienten Patienten NNP cord-015365-iqdi99pd 146 11 mit mit NNP cord-015365-iqdi99pd 146 12 einem einem NNP cord-015365-iqdi99pd 146 13 Mismatch Mismatch NNP cord-015365-iqdi99pd 146 14 54 54 CD cord-015365-iqdi99pd 146 15 % % NN cord-015365-iqdi99pd 146 16 und und IN cord-015365-iqdi99pd 146 17 von von NNP cord-015365-iqdi99pd 146 18 Patienten Patienten NNP cord-015365-iqdi99pd 146 19 mit mit NNP cord-015365-iqdi99pd 146 20 zwei zwei NNP cord-015365-iqdi99pd 146 21 bzw bzw NNP cord-015365-iqdi99pd 146 22 . . . cord-015365-iqdi99pd 147 1 drei drei NNP cord-015365-iqdi99pd 147 2 Mismatches Mismatches NNP cord-015365-iqdi99pd 147 3 36 36 CD cord-015365-iqdi99pd 147 4 % % NN cord-015365-iqdi99pd 147 5 bzw bzw NNP cord-015365-iqdi99pd 147 6 . . . cord-015365-iqdi99pd 148 1 14 14 CD cord-015365-iqdi99pd 148 2 % % NN cord-015365-iqdi99pd 148 3 . . . cord-015365-iqdi99pd 149 1 Eine Eine NNP cord-015365-iqdi99pd 149 2 Erklärung Erklärung NNP cord-015365-iqdi99pd 150 1 für für NNP cord-015365-iqdi99pd 150 2 dieses dieses NNP cord-015365-iqdi99pd 150 3 Ergebnis Ergebnis NNP cord-015365-iqdi99pd 150 4 könnte könnte NNP cord-015365-iqdi99pd 150 5 der der NNP cord-015365-iqdi99pd 150 6 Graft Graft NNP cord-015365-iqdi99pd 150 7 - - HYPH cord-015365-iqdi99pd 150 8 versus versus NN cord-015365-iqdi99pd 150 9 - - HYPH cord-015365-iqdi99pd 150 10 Leukämie Leukämie NNP cord-015365-iqdi99pd 150 11 Effekt Effekt NNP cord-015365-iqdi99pd 150 12 sein sein NNP cord-015365-iqdi99pd 150 13 , , , cord-015365-iqdi99pd 150 14 der der NNP cord-015365-iqdi99pd 150 15 durch durch NNP cord-015365-iqdi99pd 150 16 die die NNP cord-015365-iqdi99pd 151 1 erhöhte erhöhte NNP cord-015365-iqdi99pd 151 2 Anzahl Anzahl NNP cord-015365-iqdi99pd 151 3 an an DT cord-015365-iqdi99pd 151 4 Spender Spender NNP cord-015365-iqdi99pd 151 5 T T NNP cord-015365-iqdi99pd 151 6 - - HYPH cord-015365-iqdi99pd 151 7 Zellen Zellen NNP cord-015365-iqdi99pd 151 8 induziert induziert NN cord-015365-iqdi99pd 151 9 wird wird NNP cord-015365-iqdi99pd 151 10 , , , cord-015365-iqdi99pd 151 11 die die VB cord-015365-iqdi99pd 152 1 verschiedene verschiedene NNP cord-015365-iqdi99pd 152 2 hämatopoetisch hämatopoetisch NNP cord-015365-iqdi99pd 152 3 - - HYPH cord-015365-iqdi99pd 152 4 restringierte restringierte NNP cord-015365-iqdi99pd 152 5 mHag mHag NNP cord-015365-iqdi99pd 152 6 auf auf NNP cord-015365-iqdi99pd 152 7 den den NNP cord-015365-iqdi99pd 152 8 residuellen residuellen NNP cord-015365-iqdi99pd 152 9 Leukämiezellen Leukämiezellen NNP cord-015365-iqdi99pd 152 10 des des NNP cord-015365-iqdi99pd 152 11 Patienten Patienten NNP cord-015365-iqdi99pd 152 12 erkennen erkennen NNP cord-015365-iqdi99pd 152 13 und und IN cord-015365-iqdi99pd 153 1 diese diese NNP cord-015365-iqdi99pd 153 2 zerstören zerstören NNP cord-015365-iqdi99pd 153 3 . . . cord-015365-iqdi99pd 154 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 154 2 . . . cord-015365-iqdi99pd 155 1 Die die VB cord-015365-iqdi99pd 155 2 Bestimmung Bestimmung NNP cord-015365-iqdi99pd 155 3 von von NNP cord-015365-iqdi99pd 155 4 mHag mHag NNP cord-015365-iqdi99pd 155 5 in in IN cord-015365-iqdi99pd 156 1 Patient patient JJ cord-015365-iqdi99pd 156 2 und und IN cord-015365-iqdi99pd 156 3 Spender spender NN cord-015365-iqdi99pd 156 4 vor vor NNP cord-015365-iqdi99pd 156 5 der der NNP cord-015365-iqdi99pd 156 6 SZT SZT NNP cord-015365-iqdi99pd 156 7 wäre wäre NNP cord-015365-iqdi99pd 156 8 eine eine NNP cord-015365-iqdi99pd 156 9 sinnvolle sinnvolle NN cord-015365-iqdi99pd 157 1 Maßnahme Maßnahme NNP cord-015365-iqdi99pd 157 2 zur zur NNP cord-015365-iqdi99pd 157 3 zusätzlichen zusätzlichen NNP cord-015365-iqdi99pd 157 4 Risikoabschätzung Risikoabschätzung NNP cord-015365-iqdi99pd 157 5 von von NNP cord-015365-iqdi99pd 157 6 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 157 7 , , , cord-015365-iqdi99pd 157 8 vor vor NNP cord-015365-iqdi99pd 157 9 allem allem FW cord-015365-iqdi99pd 157 10 aber aber NNP cord-015365-iqdi99pd 157 11 Ü ü NN cord-015365-iqdi99pd 157 12 berleben berleben NN cord-015365-iqdi99pd 157 13 nach nach NNP cord-015365-iqdi99pd 157 14 SZT SZT NNP cord-015365-iqdi99pd 157 15 . . . cord-015365-iqdi99pd 157 16 " " '' cord-015365-iqdi99pd 158 1 Stuhltransplantation Stuhltransplantation NNP cord-015365-iqdi99pd 158 2 " " `` cord-015365-iqdi99pd 158 3 als als NN cord-015365-iqdi99pd 158 4 erfolgreiche erfolgreiche NNP cord-015365-iqdi99pd 158 5 Therapie Therapie NNP cord-015365-iqdi99pd 158 6 bei bei NNP cord-015365-iqdi99pd 158 7 schwerer schwerer NN cord-015365-iqdi99pd 158 8 idiopathischer idiopathischer NN cord-015365-iqdi99pd 158 9 Enterocolitis Enterocolitis NNP cord-015365-iqdi99pd 158 10 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 158 11 . . . cord-015365-iqdi99pd 159 1 Die die VB cord-015365-iqdi99pd 159 2 normale normale FW cord-015365-iqdi99pd 159 3 humane humane JJ cord-015365-iqdi99pd 159 4 Darmflora Darmflora NNP cord-015365-iqdi99pd 159 5 umfasst umfasst NNP cord-015365-iqdi99pd 159 6 etwa etwa NNP cord-015365-iqdi99pd 159 7 100 100 CD cord-015365-iqdi99pd 159 8 Billionen Billionen NNP cord-015365-iqdi99pd 159 9 Bakterien Bakterien NNP cord-015365-iqdi99pd 159 10 , , , cord-015365-iqdi99pd 159 11 von von NNP cord-015365-iqdi99pd 159 12 denen denen NNP cord-015365-iqdi99pd 159 13 der der NNP cord-015365-iqdi99pd 159 14 Großteil Großteil NNP cord-015365-iqdi99pd 159 15 mit mit VBD cord-015365-iqdi99pd 159 16 konventionellen konventionellen NNP cord-015365-iqdi99pd 159 17 Methoden Methoden NNP cord-015365-iqdi99pd 159 18 nicht nicht NNP cord-015365-iqdi99pd 159 19 kultivierbar kultivierbar NNP cord-015365-iqdi99pd 159 20 ist ist NN cord-015365-iqdi99pd 159 21 . . . cord-015365-iqdi99pd 160 1 Störungen Störungen NNP cord-015365-iqdi99pd 160 2 in in IN cord-015365-iqdi99pd 160 3 der der NNP cord-015365-iqdi99pd 160 4 Zusammensetzung Zusammensetzung NNP cord-015365-iqdi99pd 160 5 der der NNP cord-015365-iqdi99pd 160 6 Darmflora Darmflora NNP cord-015365-iqdi99pd 160 7 scheinen scheinen NNP cord-015365-iqdi99pd 160 8 bei bei NNP cord-015365-iqdi99pd 160 9 der der NNP cord-015365-iqdi99pd 160 10 Entstehung Entstehung NNP cord-015365-iqdi99pd 160 11 von von NNP cord-015365-iqdi99pd 160 12 Darmentzündungen Darmentzündungen NNP cord-015365-iqdi99pd 160 13 und und XX cord-015365-iqdi99pd 161 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 161 2 eine eine NNP cord-015365-iqdi99pd 161 3 wichtige wichtige NN cord-015365-iqdi99pd 161 4 Rolle Rolle NNP cord-015365-iqdi99pd 161 5 zu zu NNP cord-015365-iqdi99pd 161 6 spielen spielen NNP cord-015365-iqdi99pd 161 7 . . . cord-015365-iqdi99pd 162 1 Die die VB cord-015365-iqdi99pd 162 2 fäkale fäkale NNP cord-015365-iqdi99pd 163 1 Bakterientherapie Bakterientherapie NNP cord-015365-iqdi99pd 163 2 ( ( -LRB- cord-015365-iqdi99pd 163 3 Stuhltransplantation Stuhltransplantation NNP cord-015365-iqdi99pd 163 4 ) ) -RRB- cord-015365-iqdi99pd 163 5 zielt zielt NNP cord-015365-iqdi99pd 164 1 auf auf NNP cord-015365-iqdi99pd 164 2 die die VBP cord-015365-iqdi99pd 165 1 Wiederherstellung Wiederherstellung NNP cord-015365-iqdi99pd 165 2 einer einer NNP cord-015365-iqdi99pd 166 1 gestörten gestörten NNP cord-015365-iqdi99pd 166 2 Darmflora Darmflora NNP cord-015365-iqdi99pd 166 3 durch durch NNP cord-015365-iqdi99pd 166 4 Ü Ü NNP cord-015365-iqdi99pd 166 5 bertragung bertragung NNP cord-015365-iqdi99pd 166 6 von von NNP cord-015365-iqdi99pd 166 7 Stuhl Stuhl NNP cord-015365-iqdi99pd 166 8 eines eines NNP cord-015365-iqdi99pd 166 9 Gesunden Gesunden NNP cord-015365-iqdi99pd 166 10 in in IN cord-015365-iqdi99pd 166 11 den den NNP cord-015365-iqdi99pd 166 12 Darm Darm NNP cord-015365-iqdi99pd 166 13 eines eine NNS cord-015365-iqdi99pd 166 14 Erkrankten Erkrankten NNP cord-015365-iqdi99pd 166 15 . . . cord-015365-iqdi99pd 167 1 Diese Diese NNP cord-015365-iqdi99pd 167 2 Therapie Therapie NNP cord-015365-iqdi99pd 167 3 wird wird NNP cord-015365-iqdi99pd 167 4 erfolgreich erfolgreich JJ cord-015365-iqdi99pd 167 5 bei bei NNP cord-015365-iqdi99pd 167 6 therapierefraktären therapierefraktären NNP cord-015365-iqdi99pd 167 7 Clostridium Clostridium NNP cord-015365-iqdi99pd 167 8 difficile difficile NN cord-015365-iqdi99pd 167 9 Infektionen Infektionen NNP cord-015365-iqdi99pd 167 10 eingesetzt eingesetzt VBD cord-015365-iqdi99pd 167 11 . . . cord-015365-iqdi99pd 168 1 Fallbericht Fallbericht NNP cord-015365-iqdi99pd 168 2 und und IN cord-015365-iqdi99pd 168 3 Methodik Methodik NNP cord-015365-iqdi99pd 168 4 . . . cord-015365-iqdi99pd 169 1 Eine Eine NNP cord-015365-iqdi99pd 170 1 16-jährige 16-jährige CD cord-015365-iqdi99pd 170 2 Patientin Patientin NNP cord-015365-iqdi99pd 170 3 wurde wurde VBD cord-015365-iqdi99pd 170 4 aufgrund aufgrund NNP cord-015365-iqdi99pd 170 5 eines eines NNP cord-015365-iqdi99pd 170 6 Schädelhirntraumas Schädelhirntraumas NNP cord-015365-iqdi99pd 170 7 intensivmedizinisch intensivmedizinisch NNP cord-015365-iqdi99pd 170 8 behandelt behandelt NNP cord-015365-iqdi99pd 170 9 . . . cord-015365-iqdi99pd 171 1 Unter Unter NNP cord-015365-iqdi99pd 171 2 einer einer NNP cord-015365-iqdi99pd 171 3 mehrfachen mehrfachen NNP cord-015365-iqdi99pd 171 4 , , , cord-015365-iqdi99pd 171 5 antibiotischen antibiotischen NNP cord-015365-iqdi99pd 171 6 Therapie Therapie NNP cord-015365-iqdi99pd 171 7 in in IN cord-015365-iqdi99pd 171 8 Kombination Kombination NNP cord-015365-iqdi99pd 171 9 mit mit NNP cord-015365-iqdi99pd 171 10 Steroiden Steroiden NNP cord-015365-iqdi99pd 171 11 entwickelte entwickelte NNP cord-015365-iqdi99pd 171 12 die die VBP cord-015365-iqdi99pd 171 13 Patientin Patientin NNP cord-015365-iqdi99pd 171 14 eine eine NNP cord-015365-iqdi99pd 171 15 schwere schwere NN cord-015365-iqdi99pd 171 16 Enterocolitis Enterocolitis NNP cord-015365-iqdi99pd 171 17 mit mit NNP cord-015365-iqdi99pd 171 18 ausgeprägter ausgeprägter NNP cord-015365-iqdi99pd 171 19 Diarrhoe Diarrhoe NNP cord-015365-iqdi99pd 172 1 ( ( -LRB- cord-015365-iqdi99pd 172 2 bis bis NNP cord-015365-iqdi99pd 172 3 zu zu NNP cord-015365-iqdi99pd 172 4 7 7 CD cord-015365-iqdi99pd 172 5 Litern Litern NNP cord-015365-iqdi99pd 172 6 Stuhl Stuhl NNP cord-015365-iqdi99pd 172 7 pro pro JJ cord-015365-iqdi99pd 172 8 Tag tag NN cord-015365-iqdi99pd 172 9 ) ) -RRB- cord-015365-iqdi99pd 172 10 . . . cord-015365-iqdi99pd 173 1 Die die VB cord-015365-iqdi99pd 173 2 histologischen histologischen NN cord-015365-iqdi99pd 173 3 und und IN cord-015365-iqdi99pd 173 4 endoskopischen endoskopischen NNP cord-015365-iqdi99pd 173 5 Befunde Befunde NNP cord-015365-iqdi99pd 173 6 der der NNP cord-015365-iqdi99pd 173 7 Darmentzündung Darmentzündung NNP cord-015365-iqdi99pd 173 8 zeigte zeigte NN cord-015365-iqdi99pd 173 9 das das NNP cord-015365-iqdi99pd 173 10 Bild Bild NNP cord-015365-iqdi99pd 173 11 einer einer NNP cord-015365-iqdi99pd 173 12 Graft Graft NNP cord-015365-iqdi99pd 173 13 versus versus IN cord-015365-iqdi99pd 173 14 Host Host NNP cord-015365-iqdi99pd 173 15 Disease Disease NNP cord-015365-iqdi99pd 173 16 ( ( -LRB- cord-015365-iqdi99pd 173 17 GvHD GvHD NNP cord-015365-iqdi99pd 173 18 ) ) -RRB- cord-015365-iqdi99pd 173 19 artigen artigen NNP cord-015365-iqdi99pd 173 20 Entzündung Entzündung NNP cord-015365-iqdi99pd 173 21 . . . cord-015365-iqdi99pd 174 1 Eine Eine NNP cord-015365-iqdi99pd 174 2 Abklärung Abklärung NNP cord-015365-iqdi99pd 174 3 auf auf NNP cord-015365-iqdi99pd 174 4 mögliche mögliche NN cord-015365-iqdi99pd 174 5 Ursachen Ursachen NNP cord-015365-iqdi99pd 175 1 insbesondere insbesondere NNP cord-015365-iqdi99pd 175 2 auf auf NNP cord-015365-iqdi99pd 175 3 infektiöse infektiöse NNP cord-015365-iqdi99pd 175 4 Erreger Erreger NNP cord-015365-iqdi99pd 175 5 blieb blieb NNP cord-015365-iqdi99pd 176 1 negativ negativ NNP cord-015365-iqdi99pd 176 2 . . . cord-015365-iqdi99pd 177 1 I -PRON- PRP cord-015365-iqdi99pd 177 2 m be VBP cord-015365-iqdi99pd 177 3 Verlauf Verlauf NNP cord-015365-iqdi99pd 177 4 nach nach NNP cord-015365-iqdi99pd 177 5 8 8 CD cord-015365-iqdi99pd 178 1 Wochen Wochen NNP cord-015365-iqdi99pd 178 2 kam kam NNP cord-015365-iqdi99pd 179 1 es es XX cord-015365-iqdi99pd 179 2 zu zu NNP cord-015365-iqdi99pd 179 3 einer einer NNP cord-015365-iqdi99pd 179 4 spontanen spontanen NNP cord-015365-iqdi99pd 180 1 Besserung Besserung NNP cord-015365-iqdi99pd 180 2 der der NNP cord-015365-iqdi99pd 180 3 Entzündung Entzündung NNP cord-015365-iqdi99pd 181 1 i -PRON- PRP cord-015365-iqdi99pd 181 2 m be VBP cord-015365-iqdi99pd 181 3 Dünndarm Dünndarm NNP cord-015365-iqdi99pd 182 1 , , , cord-015365-iqdi99pd 182 2 i -PRON- PRP cord-015365-iqdi99pd 182 3 m be VBP cord-015365-iqdi99pd 182 4 Dickdarm Dickdarm NNP cord-015365-iqdi99pd 182 5 persistierte persistierte NNS cord-015365-iqdi99pd 182 6 jedoch jedoch NNP cord-015365-iqdi99pd 182 7 die die VBP cord-015365-iqdi99pd 182 8 schwere schwere NNP cord-015365-iqdi99pd 182 9 Colitis Colitis NNP cord-015365-iqdi99pd 182 10 . . . cord-015365-iqdi99pd 183 1 In in IN cord-015365-iqdi99pd 183 2 den den NNP cord-015365-iqdi99pd 183 3 histologischen histologischen JJ cord-015365-iqdi99pd 183 4 Proben Proben NNP cord-015365-iqdi99pd 183 5 aus aus NNP cord-015365-iqdi99pd 183 6 dem dem NNP cord-015365-iqdi99pd 183 7 Colon colon NN cord-015365-iqdi99pd 183 8 zeigte zeigte NN cord-015365-iqdi99pd 183 9 sich sich NNP cord-015365-iqdi99pd 183 10 ein ein NNP cord-015365-iqdi99pd 183 11 fast fast JJ cord-015365-iqdi99pd 183 12 kompletter kompletter NNP cord-015365-iqdi99pd 183 13 Verlust Verlust NNP cord-015365-iqdi99pd 183 14 des des NNP cord-015365-iqdi99pd 183 15 Epithels Epithels NNPS cord-015365-iqdi99pd 183 16 . . . cord-015365-iqdi99pd 184 1 Als Als NNP cord-015365-iqdi99pd 184 2 Ursache Ursache NNP cord-015365-iqdi99pd 184 3 der der NN cord-015365-iqdi99pd 184 4 Colitis Colitis NNP cord-015365-iqdi99pd 184 5 wurde wurde NN cord-015365-iqdi99pd 184 6 eine eine NNP cord-015365-iqdi99pd 184 7 Störung Störung NNP cord-015365-iqdi99pd 184 8 der der NNP cord-015365-iqdi99pd 184 9 Darmflora Darmflora NNP cord-015365-iqdi99pd 184 10 durch durch NNP cord-015365-iqdi99pd 184 11 die die NN cord-015365-iqdi99pd 184 12 antibiotische antibiotische NN cord-015365-iqdi99pd 185 1 Therapie Therapie NNP cord-015365-iqdi99pd 185 2 angenommen angenommen NNP cord-015365-iqdi99pd 185 3 und und IN cord-015365-iqdi99pd 185 4 deshalb deshalb NNP cord-015365-iqdi99pd 185 5 bei bei NNP cord-015365-iqdi99pd 185 6 der der NNP cord-015365-iqdi99pd 185 7 Patientin Patientin NNP cord-015365-iqdi99pd 185 8 eine eine NNP cord-015365-iqdi99pd 185 9 Stuhltransplantation Stuhltransplantation NNP cord-015365-iqdi99pd 185 10 durchgeführt durchgeführt NN cord-015365-iqdi99pd 185 11 . . . cord-015365-iqdi99pd 186 1 Als Als NNP cord-015365-iqdi99pd 186 2 Stuhlspender Stuhlspender NNP cord-015365-iqdi99pd 186 3 wurde wurde NNP cord-015365-iqdi99pd 186 4 die die VBP cord-015365-iqdi99pd 186 5 gesunde gesunde NNP cord-015365-iqdi99pd 186 6 Mutter Mutter NNP cord-015365-iqdi99pd 186 7 der der NNP cord-015365-iqdi99pd 186 8 Patientin Patientin NNP cord-015365-iqdi99pd 186 9 herangezogen herangezogen NNP cord-015365-iqdi99pd 186 10 , , , cord-015365-iqdi99pd 186 11 diese diese NNP cord-015365-iqdi99pd 186 12 wurde wurde NNP cord-015365-iqdi99pd 186 13 zuvor zuvor NNP cord-015365-iqdi99pd 186 14 auf auf NNP cord-015365-iqdi99pd 186 15 übertragbare übertragbare NN cord-015365-iqdi99pd 186 16 Infektionskrankheiten Infektionskrankheiten NNP cord-015365-iqdi99pd 186 17 getestet getestet NNP cord-015365-iqdi99pd 186 18 . . . cord-015365-iqdi99pd 187 1 Der Der NNP cord-015365-iqdi99pd 187 2 Stuhl Stuhl NNP cord-015365-iqdi99pd 187 3 wurde wurde NN cord-015365-iqdi99pd 187 4 mit mit NNP cord-015365-iqdi99pd 187 5 Kochsalzlösung Kochsalzlösung NNP cord-015365-iqdi99pd 187 6 verflüssigt verflüssigt NNP cord-015365-iqdi99pd 188 1 und und NNP cord-015365-iqdi99pd 188 2 filtriert filtriert NNP cord-015365-iqdi99pd 188 3 . . . cord-015365-iqdi99pd 189 1 I -PRON- PRP cord-015365-iqdi99pd 189 2 m be VBP cord-015365-iqdi99pd 189 3 Anschluss Anschluss NNP cord-015365-iqdi99pd 189 4 wurde wurde NN cord-015365-iqdi99pd 189 5 bei bei NNP cord-015365-iqdi99pd 189 6 der der NNP cord-015365-iqdi99pd 189 7 Patientin Patientin NNP cord-015365-iqdi99pd 189 8 eine eine NNP cord-015365-iqdi99pd 189 9 Coloskopie Coloskopie NNP cord-015365-iqdi99pd 189 10 durchgeführt durchgeführt NN cord-015365-iqdi99pd 189 11 und und IN cord-015365-iqdi99pd 189 12 insgesamt insgesamt NNP cord-015365-iqdi99pd 190 1 400 400 CD cord-015365-iqdi99pd 190 2 ml ml NN cord-015365-iqdi99pd 190 3 des des FW cord-015365-iqdi99pd 190 4 flüssigen flüssigen NNP cord-015365-iqdi99pd 190 5 Spenderstuhls Spenderstuhls NNP cord-015365-iqdi99pd 190 6 in in IN cord-015365-iqdi99pd 190 7 das das NNP cord-015365-iqdi99pd 190 8 Ileum Ileum NNP cord-015365-iqdi99pd 190 9 und und IN cord-015365-iqdi99pd 190 10 Colon Colon NNP cord-015365-iqdi99pd 190 11 appliziert appliziert NN cord-015365-iqdi99pd 190 12 . . . cord-015365-iqdi99pd 191 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 191 2 . . . cord-015365-iqdi99pd 192 1 Die die VB cord-015365-iqdi99pd 192 2 Stuhltransplantation Stuhltransplantation NNP cord-015365-iqdi99pd 192 3 führte führte NN cord-015365-iqdi99pd 192 4 bei bei NNP cord-015365-iqdi99pd 192 5 der der NNP cord-015365-iqdi99pd 192 6 Patientin Patientin NNP cord-015365-iqdi99pd 192 7 in in IN cord-015365-iqdi99pd 192 8 der der NNP cord-015365-iqdi99pd 192 9 endoskopischen endoskopischen NNP cord-015365-iqdi99pd 192 10 Kontrolle Kontrolle NNP cord-015365-iqdi99pd 192 11 nach nach NNP cord-015365-iqdi99pd 192 12 1 1 CD cord-015365-iqdi99pd 192 13 Woche Woche NNP cord-015365-iqdi99pd 192 14 zu zu NNP cord-015365-iqdi99pd 192 15 einer einer NNP cord-015365-iqdi99pd 192 16 rapiden rapiden NNP cord-015365-iqdi99pd 193 1 Besserung Besserung NNP cord-015365-iqdi99pd 193 2 vor vor NNP cord-015365-iqdi99pd 193 3 allem allem NNP cord-015365-iqdi99pd 193 4 des des FW cord-015365-iqdi99pd 193 5 histologischen histologischen NNP cord-015365-iqdi99pd 193 6 Befundes Befundes NNP cord-015365-iqdi99pd 193 7 . . . cord-015365-iqdi99pd 194 1 Ebenso Ebenso NNP cord-015365-iqdi99pd 194 2 kam kam NNP cord-015365-iqdi99pd 194 3 es es XX cord-015365-iqdi99pd 194 4 zu zu NNP cord-015365-iqdi99pd 194 5 einem einem NNP cord-015365-iqdi99pd 194 6 schrittweisen schrittweisen NNP cord-015365-iqdi99pd 195 1 Rückgang Rückgang NNP cord-015365-iqdi99pd 195 2 des des NNP cord-015365-iqdi99pd 195 3 Stuhlvolumens Stuhlvolumens NNP cord-015365-iqdi99pd 195 4 mit mit NNP cord-015365-iqdi99pd 195 5 Normalisierung Normalisierung NNP cord-015365-iqdi99pd 195 6 der der NNP cord-015365-iqdi99pd 195 7 Stuhlfrequenz Stuhlfrequenz NNP cord-015365-iqdi99pd 195 8 nach nach NN cord-015365-iqdi99pd 195 9 6 6 CD cord-015365-iqdi99pd 195 10 Wochen Wochen NNP cord-015365-iqdi99pd 195 11 . . . cord-015365-iqdi99pd 196 1 In in IN cord-015365-iqdi99pd 196 2 der der NNP cord-015365-iqdi99pd 196 3 Kontrolle Kontrolle NNP cord-015365-iqdi99pd 196 4 nach nach NN cord-015365-iqdi99pd 196 5 2 2 CD cord-015365-iqdi99pd 196 6 Monaten Monaten NNP cord-015365-iqdi99pd 196 7 war war NN cord-015365-iqdi99pd 196 8 der der NN cord-015365-iqdi99pd 196 9 endoskopische endoskopische VBN cord-015365-iqdi99pd 196 10 und und DT cord-015365-iqdi99pd 197 1 histologische histologische NNP cord-015365-iqdi99pd 197 2 Befund Befund NNP cord-015365-iqdi99pd 197 3 i -PRON- PRP cord-015365-iqdi99pd 197 4 m be VBP cord-015365-iqdi99pd 197 5 Colon Colon NNP cord-015365-iqdi99pd 197 6 normal normal JJ cord-015365-iqdi99pd 197 7 . . . cord-015365-iqdi99pd 198 1 I -PRON- PRP cord-015365-iqdi99pd 198 2 m be VBP cord-015365-iqdi99pd 199 1 weiteren weiteren NNP cord-015365-iqdi99pd 199 2 Beobachtungszeitraum Beobachtungszeitraum NNP cord-015365-iqdi99pd 199 3 nach nach NNP cord-015365-iqdi99pd 199 4 5 5 CD cord-015365-iqdi99pd 199 5 Monaten Monaten NNP cord-015365-iqdi99pd 199 6 ist ist NN cord-015365-iqdi99pd 199 7 es es XX cord-015365-iqdi99pd 199 8 zu zu NNP cord-015365-iqdi99pd 199 9 keiner keiner NNP cord-015365-iqdi99pd 200 1 neuerlichen neuerlichen NNP cord-015365-iqdi99pd 200 2 Reaktivierung Reaktivierung NNP cord-015365-iqdi99pd 200 3 der der NNP cord-015365-iqdi99pd 200 4 idiopathischen idiopathischen NNP cord-015365-iqdi99pd 201 1 Enterocolitis Enterocolitis NNP cord-015365-iqdi99pd 201 2 gekommen gekommen NNP cord-015365-iqdi99pd 201 3 . . . cord-015365-iqdi99pd 202 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 202 2 . . . cord-015365-iqdi99pd 203 1 Die die VB cord-015365-iqdi99pd 203 2 GvHD GvHD NNP cord-015365-iqdi99pd 203 3 - - HYPH cord-015365-iqdi99pd 203 4 artige artige NNP cord-015365-iqdi99pd 203 5 idiopathische idiopathische NNP cord-015365-iqdi99pd 204 1 Enterocolitis Enterocolitis NNP cord-015365-iqdi99pd 204 2 nach nach NNP cord-015365-iqdi99pd 204 3 Antibiotikatherapie Antibiotikatherapie NNP cord-015365-iqdi99pd 204 4 scheint scheint NNP cord-015365-iqdi99pd 205 1 durch durch NNP cord-015365-iqdi99pd 205 2 eine eine NNP cord-015365-iqdi99pd 205 3 persistierende persistierende NNP cord-015365-iqdi99pd 205 4 Störung Störung NNP cord-015365-iqdi99pd 205 5 der der NNP cord-015365-iqdi99pd 205 6 Darmflora Darmflora NNP cord-015365-iqdi99pd 205 7 mitbedingt mitbedingt NNP cord-015365-iqdi99pd 205 8 zu zu NNP cord-015365-iqdi99pd 205 9 sein sein NNP cord-015365-iqdi99pd 205 10 . . . cord-015365-iqdi99pd 206 1 Die die VB cord-015365-iqdi99pd 206 2 Stuhltransplantation Stuhltransplantation NNP cord-015365-iqdi99pd 206 3 war war NN cord-015365-iqdi99pd 206 4 bei bei NN cord-015365-iqdi99pd 206 5 der der NNP cord-015365-iqdi99pd 206 6 beschriebenen beschriebenen NNP cord-015365-iqdi99pd 207 1 Patientin Patientin NNP cord-015365-iqdi99pd 207 2 mit mit NNP cord-015365-iqdi99pd 207 3 diesem diesem NNP cord-015365-iqdi99pd 207 4 schweren schweren VBZ cord-015365-iqdi99pd 207 5 Krankheitsbild Krankheitsbild NNP cord-015365-iqdi99pd 207 6 eine eine FW cord-015365-iqdi99pd 207 7 sehr sehr NNP cord-015365-iqdi99pd 207 8 effektive effektive NNP cord-015365-iqdi99pd 207 9 Therapiemaßnahme Therapiemaßnahme NNP cord-015365-iqdi99pd 207 10 . . . cord-015365-iqdi99pd 208 1 Tissue tissue NN cord-015365-iqdi99pd 208 2 specific specific JJ cord-015365-iqdi99pd 208 3 epigenetic epigenetic JJ cord-015365-iqdi99pd 208 4 memory memory NN cord-015365-iqdi99pd 208 5 : : : cord-015365-iqdi99pd 209 1 differentiation differentiation NN cord-015365-iqdi99pd 209 2 capacity capacity NN cord-015365-iqdi99pd 209 3 of of IN cord-015365-iqdi99pd 209 4 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 209 5 stem stem NN cord-015365-iqdi99pd 209 6 cell cell NN cord-015365-iqdi99pd 209 7 is be VBZ cord-015365-iqdi99pd 209 8 restricted restrict VBN cord-015365-iqdi99pd 209 9 to to IN cord-015365-iqdi99pd 209 10 their -PRON- PRP$ cord-015365-iqdi99pd 209 11 tissue tissue NN cord-015365-iqdi99pd 209 12 of of IN cord-015365-iqdi99pd 209 13 origin origin NN cord-015365-iqdi99pd 209 14 Human human JJ cord-015365-iqdi99pd 209 15 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 209 16 stem stem NN cord-015365-iqdi99pd 209 17 and and CC cord-015365-iqdi99pd 209 18 progenitor progenitor NN cord-015365-iqdi99pd 209 19 cells cell NNS cord-015365-iqdi99pd 209 20 ( ( -LRB- cord-015365-iqdi99pd 209 21 MSPCs mspc NNS cord-015365-iqdi99pd 209 22 ) ) -RRB- cord-015365-iqdi99pd 209 23 are be VBP cord-015365-iqdi99pd 209 24 currently currently RB cord-015365-iqdi99pd 209 25 evaluated evaluate VBN cord-015365-iqdi99pd 209 26 in in IN cord-015365-iqdi99pd 209 27 clinical clinical JJ cord-015365-iqdi99pd 209 28 trials trial NNS cord-015365-iqdi99pd 209 29 for for IN cord-015365-iqdi99pd 209 30 bone bone NN cord-015365-iqdi99pd 209 31 and and CC cord-015365-iqdi99pd 209 32 marrow marrow NN cord-015365-iqdi99pd 209 33 regeneration regeneration NN cord-015365-iqdi99pd 209 34 and and CC cord-015365-iqdi99pd 209 35 their -PRON- PRP$ cord-015365-iqdi99pd 209 36 immune immune JJ cord-015365-iqdi99pd 209 37 modulation modulation NN cord-015365-iqdi99pd 209 38 potential potential NN cord-015365-iqdi99pd 209 39 . . . cord-015365-iqdi99pd 210 1 MSPCs mspc NNS cord-015365-iqdi99pd 210 2 from from IN cord-015365-iqdi99pd 210 3 virtually virtually RB cord-015365-iqdi99pd 210 4 all all DT cord-015365-iqdi99pd 210 5 tissues tissue NNS cord-015365-iqdi99pd 210 6 appear appear VBP cord-015365-iqdi99pd 210 7 indistinguishable indistinguishable JJ cord-015365-iqdi99pd 210 8 regarding regard VBG cord-015365-iqdi99pd 210 9 immunephenotype immunephenotype NN cord-015365-iqdi99pd 210 10 and and CC cord-015365-iqdi99pd 210 11 multipotent multipotent JJ cord-015365-iqdi99pd 210 12 differentiation differentiation NN cord-015365-iqdi99pd 210 13 capacity capacity NN cord-015365-iqdi99pd 210 14 in in IN cord-015365-iqdi99pd 210 15 vitro vitro FW cord-015365-iqdi99pd 210 16 . . . cord-015365-iqdi99pd 211 1 Improvements improvement NNS cord-015365-iqdi99pd 211 2 of of IN cord-015365-iqdi99pd 211 3 limited limited JJ cord-015365-iqdi99pd 211 4 clinical clinical JJ cord-015365-iqdi99pd 211 5 efficiency efficiency NN cord-015365-iqdi99pd 211 6 are be VBP cord-015365-iqdi99pd 211 7 hampered hamper VBN cord-015365-iqdi99pd 211 8 by by IN cord-015365-iqdi99pd 211 9 a a DT cord-015365-iqdi99pd 211 10 lack lack NN cord-015365-iqdi99pd 211 11 of of IN cord-015365-iqdi99pd 211 12 understanding understand VBG cord-015365-iqdi99pd 211 13 MSPC MSPC NNP cord-015365-iqdi99pd 211 14 functionality functionality NN cord-015365-iqdi99pd 211 15 in in IN cord-015365-iqdi99pd 211 16 vivo vivo NNP cord-015365-iqdi99pd 211 17 . . . cord-015365-iqdi99pd 212 1 Here here RB cord-015365-iqdi99pd 212 2 we -PRON- PRP cord-015365-iqdi99pd 212 3 demonstrate demonstrate VBP cord-015365-iqdi99pd 212 4 that that IN cord-015365-iqdi99pd 212 5 the the DT cord-015365-iqdi99pd 212 6 capacity capacity NN cord-015365-iqdi99pd 212 7 of of IN cord-015365-iqdi99pd 212 8 in in IN cord-015365-iqdi99pd 212 9 vivo vivo FW cord-015365-iqdi99pd 212 10 endochondral endochondral JJ cord-015365-iqdi99pd 212 11 bone bone NN cord-015365-iqdi99pd 212 12 formation formation NN cord-015365-iqdi99pd 212 13 followed follow VBN cord-015365-iqdi99pd 212 14 by by IN cord-015365-iqdi99pd 212 15 infiltration infiltration NN cord-015365-iqdi99pd 212 16 of of IN cord-015365-iqdi99pd 212 17 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 212 18 components component NNS cord-015365-iqdi99pd 212 19 can can MD cord-015365-iqdi99pd 212 20 be be VB cord-015365-iqdi99pd 212 21 used use VBN cord-015365-iqdi99pd 212 22 as as IN cord-015365-iqdi99pd 212 23 a a DT cord-015365-iqdi99pd 212 24 surrogate surrogate NN cord-015365-iqdi99pd 212 25 to to TO cord-015365-iqdi99pd 212 26 determine determine VB cord-015365-iqdi99pd 212 27 in in IN cord-015365-iqdi99pd 212 28 vivo vivo NNP cord-015365-iqdi99pd 212 29 MSPC MSPC NNP cord-015365-iqdi99pd 212 30 - - HYPH cord-015365-iqdi99pd 212 31 multipotentiality multipotentiality NN cord-015365-iqdi99pd 212 32 . . . cord-015365-iqdi99pd 213 1 MSPCs mspc NNS cord-015365-iqdi99pd 213 2 from from IN cord-015365-iqdi99pd 213 3 bone bone NN cord-015365-iqdi99pd 213 4 marrow marrow NN cord-015365-iqdi99pd 213 5 ( ( -LRB- cord-015365-iqdi99pd 213 6 BM BM NNP cord-015365-iqdi99pd 213 7 ) ) -RRB- cord-015365-iqdi99pd 213 8 , , , cord-015365-iqdi99pd 213 9 adipose adipose JJ cord-015365-iqdi99pd 213 10 tissue tissue NN cord-015365-iqdi99pd 213 11 ( ( -LRB- cord-015365-iqdi99pd 213 12 AT at IN cord-015365-iqdi99pd 213 13 ) ) -RRB- cord-015365-iqdi99pd 213 14 and and CC cord-015365-iqdi99pd 213 15 umbilical umbilical JJ cord-015365-iqdi99pd 213 16 cord cord NN cord-015365-iqdi99pd 213 17 ( ( -LRB- cord-015365-iqdi99pd 213 18 UC UC NNP cord-015365-iqdi99pd 213 19 ) ) -RRB- cord-015365-iqdi99pd 213 20 have have VBP cord-015365-iqdi99pd 213 21 been be VBN cord-015365-iqdi99pd 213 22 isolated isolate VBN cord-015365-iqdi99pd 213 23 . . . cord-015365-iqdi99pd 214 1 Comparative comparative JJ cord-015365-iqdi99pd 214 2 analysis analysis NN cord-015365-iqdi99pd 214 3 of of IN cord-015365-iqdi99pd 214 4 immune immune JJ cord-015365-iqdi99pd 214 5 - - HYPH cord-015365-iqdi99pd 214 6 phenotype phenotype NN cord-015365-iqdi99pd 214 7 , , , cord-015365-iqdi99pd 214 8 adipo- adipo- RB cord-015365-iqdi99pd 214 9 , , , cord-015365-iqdi99pd 214 10 chondro chondro NN cord-015365-iqdi99pd 214 11 - - : cord-015365-iqdi99pd 214 12 and and CC cord-015365-iqdi99pd 214 13 osteogenic osteogenic JJ cord-015365-iqdi99pd 214 14 differentiation differentiation NN cord-015365-iqdi99pd 214 15 potential potential NN cord-015365-iqdi99pd 214 16 in in IN cord-015365-iqdi99pd 214 17 vitro vitro FW cord-015365-iqdi99pd 214 18 as as RB cord-015365-iqdi99pd 214 19 well well RB cord-015365-iqdi99pd 214 20 as as IN cord-015365-iqdi99pd 214 21 expression expression NN cord-015365-iqdi99pd 214 22 analysis analysis NN cord-015365-iqdi99pd 214 23 of of IN cord-015365-iqdi99pd 214 24 key key JJ cord-015365-iqdi99pd 214 25 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 214 26 lineage lineage NN cord-015365-iqdi99pd 214 27 genes gene NNS cord-015365-iqdi99pd 214 28 were be VBD cord-015365-iqdi99pd 214 29 performed perform VBN cord-015365-iqdi99pd 214 30 . . . cord-015365-iqdi99pd 215 1 Epigenetic epigenetic JJ cord-015365-iqdi99pd 215 2 profiling profiling NN cord-015365-iqdi99pd 215 3 of of IN cord-015365-iqdi99pd 215 4 MSPCs mspc NNS cord-015365-iqdi99pd 215 5 was be VBD cord-015365-iqdi99pd 215 6 done do VBN cord-015365-iqdi99pd 215 7 using use VBG cord-015365-iqdi99pd 215 8 a a DT cord-015365-iqdi99pd 215 9 methylation methylation NN cord-015365-iqdi99pd 215 10 array array NN cord-015365-iqdi99pd 215 11 . . . cord-015365-iqdi99pd 216 1 In in IN cord-015365-iqdi99pd 216 2 vivo vivo NN cord-015365-iqdi99pd 216 3 differentiation differentiation NN cord-015365-iqdi99pd 216 4 capacity capacity NN cord-015365-iqdi99pd 216 5 was be VBD cord-015365-iqdi99pd 216 6 tested test VBN cord-015365-iqdi99pd 216 7 by by IN cord-015365-iqdi99pd 216 8 transplanting transplant VBG cord-015365-iqdi99pd 216 9 MSPCs mspc NNS cord-015365-iqdi99pd 216 10 subcutaneously subcutaneously RB cord-015365-iqdi99pd 216 11 into into IN cord-015365-iqdi99pd 216 12 immune immune NN cord-015365-iqdi99pd 216 13 - - HYPH cord-015365-iqdi99pd 216 14 compromised compromise VBN cord-015365-iqdi99pd 216 15 mice mouse NNS cord-015365-iqdi99pd 216 16 . . . cord-015365-iqdi99pd 217 1 The the DT cord-015365-iqdi99pd 217 2 developmental developmental JJ cord-015365-iqdi99pd 217 3 sequence sequence NN cord-015365-iqdi99pd 217 4 of of IN cord-015365-iqdi99pd 217 5 chondrogenic chondrogenic NNP cord-015365-iqdi99pd 217 6 and and CC cord-015365-iqdi99pd 217 7 osteogenic osteogenic JJ cord-015365-iqdi99pd 217 8 as as IN cord-015365-iqdi99pd 217 9 compared compare VBN cord-015365-iqdi99pd 217 10 to to IN cord-015365-iqdi99pd 217 11 perivascular perivascular JJ cord-015365-iqdi99pd 217 12 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 217 13 tissue tissue NN cord-015365-iqdi99pd 217 14 formation formation NN cord-015365-iqdi99pd 217 15 was be VBD cord-015365-iqdi99pd 217 16 analyzed analyze VBN cord-015365-iqdi99pd 217 17 . . . cord-015365-iqdi99pd 218 1 Formation formation NN cord-015365-iqdi99pd 218 2 of of IN cord-015365-iqdi99pd 218 3 a a DT cord-015365-iqdi99pd 218 4 marrow marrow NN cord-015365-iqdi99pd 218 5 niche niche NN cord-015365-iqdi99pd 218 6 with with IN cord-015365-iqdi99pd 218 7 establishment establishment NN cord-015365-iqdi99pd 218 8 of of IN cord-015365-iqdi99pd 218 9 the the DT cord-015365-iqdi99pd 218 10 complete complete JJ cord-015365-iqdi99pd 218 11 host host NN cord-015365-iqdi99pd 218 12 hematopoiesis hematopoiesis NN cord-015365-iqdi99pd 218 13 was be VBD cord-015365-iqdi99pd 218 14 studied study VBN cord-015365-iqdi99pd 218 15 . . . cord-015365-iqdi99pd 219 1 Secondary secondary JJ cord-015365-iqdi99pd 219 2 transplants transplant NNS cord-015365-iqdi99pd 219 3 of of IN cord-015365-iqdi99pd 219 4 MSPCs mspc NNS cord-015365-iqdi99pd 219 5 were be VBD cord-015365-iqdi99pd 219 6 performed perform VBN cord-015365-iqdi99pd 219 7 and and CC cord-015365-iqdi99pd 219 8 analyzed analyze VBN cord-015365-iqdi99pd 219 9 equally equally RB cord-015365-iqdi99pd 219 10 . . . cord-015365-iqdi99pd 220 1 MSPCs mspc NNS cord-015365-iqdi99pd 220 2 from from IN cord-015365-iqdi99pd 220 3 all all DT cord-015365-iqdi99pd 220 4 tissues tissue NNS cord-015365-iqdi99pd 220 5 analyzed analyze VBD cord-015365-iqdi99pd 220 6 show show VBP cord-015365-iqdi99pd 220 7 an an DT cord-015365-iqdi99pd 220 8 almost almost RB cord-015365-iqdi99pd 220 9 identical identical JJ cord-015365-iqdi99pd 220 10 immune immune JJ cord-015365-iqdi99pd 220 11 - - HYPH cord-015365-iqdi99pd 220 12 phenotype phenotype NN cord-015365-iqdi99pd 220 13 using use VBG cord-015365-iqdi99pd 220 14 a a DT cord-015365-iqdi99pd 220 15 MSPC MSPC NNP cord-015365-iqdi99pd 220 16 marker marker NN cord-015365-iqdi99pd 220 17 profile profile NN cord-015365-iqdi99pd 220 18 . . . cord-015365-iqdi99pd 221 1 Osteo Osteo NNP cord-015365-iqdi99pd 221 2 - - HYPH cord-015365-iqdi99pd 221 3 and and CC cord-015365-iqdi99pd 221 4 adipogenic adipogenic JJ cord-015365-iqdi99pd 221 5 differentiation differentiation NN cord-015365-iqdi99pd 221 6 potential potential NN cord-015365-iqdi99pd 221 7 in in IN cord-015365-iqdi99pd 221 8 vitro vitro FW cord-015365-iqdi99pd 221 9 as as RB cord-015365-iqdi99pd 221 10 well well RB cord-015365-iqdi99pd 221 11 as as IN cord-015365-iqdi99pd 221 12 gene gene NN cord-015365-iqdi99pd 221 13 expression expression NN cord-015365-iqdi99pd 221 14 can can MD cord-015365-iqdi99pd 221 15 not not RB cord-015365-iqdi99pd 221 16 distinguish distinguish VB cord-015365-iqdi99pd 221 17 tissuespecific tissuespecific JJ cord-015365-iqdi99pd 221 18 MSPCs mspc NNS cord-015365-iqdi99pd 221 19 . . . cord-015365-iqdi99pd 222 1 MSPCs mspc NNS cord-015365-iqdi99pd 222 2 from from IN cord-015365-iqdi99pd 222 3 all all DT cord-015365-iqdi99pd 222 4 tissues tissue NNS cord-015365-iqdi99pd 222 5 except except IN cord-015365-iqdi99pd 222 6 BM BM NNP cord-015365-iqdi99pd 222 7 lack lack NN cord-015365-iqdi99pd 222 8 in in IN cord-015365-iqdi99pd 222 9 vitro vitro FW cord-015365-iqdi99pd 222 10 chondrogenic chondrogenic JJ cord-015365-iqdi99pd 222 11 differentiation differentiation NN cord-015365-iqdi99pd 222 12 potential potential NN cord-015365-iqdi99pd 222 13 using use VBG cord-015365-iqdi99pd 222 14 stringent stringent JJ cord-015365-iqdi99pd 222 15 3D 3d JJ cord-015365-iqdi99pd 222 16 - - HYPH cord-015365-iqdi99pd 222 17 chon chon NNP cord-015365-iqdi99pd 222 18 - - HYPH cord-015365-iqdi99pd 222 19 drogenesis drogenesis NNP cord-015365-iqdi99pd 222 20 assays assay NNS cord-015365-iqdi99pd 222 21 followed follow VBN cord-015365-iqdi99pd 222 22 by by IN cord-015365-iqdi99pd 222 23 appropriate appropriate JJ cord-015365-iqdi99pd 222 24 histological histological JJ cord-015365-iqdi99pd 222 25 staining staining NN cord-015365-iqdi99pd 222 26 . . . cord-015365-iqdi99pd 223 1 In in IN cord-015365-iqdi99pd 223 2 vivo vivo NN cord-015365-iqdi99pd 223 3 studies study NNS cord-015365-iqdi99pd 223 4 could could MD cord-015365-iqdi99pd 223 5 strengthen strengthen VB cord-015365-iqdi99pd 223 6 these these DT cord-015365-iqdi99pd 223 7 findings finding NNS cord-015365-iqdi99pd 223 8 , , , cord-015365-iqdi99pd 223 9 because because IN cord-015365-iqdi99pd 223 10 only only RB cord-015365-iqdi99pd 223 11 BMderived BMderived NNP cord-015365-iqdi99pd 223 12 MSPCs MSPCs NNPS cord-015365-iqdi99pd 223 13 were be VBD cord-015365-iqdi99pd 223 14 able able JJ cord-015365-iqdi99pd 223 15 to to TO cord-015365-iqdi99pd 223 16 generate generate VB cord-015365-iqdi99pd 223 17 bone bone NN cord-015365-iqdi99pd 223 18 through through IN cord-015365-iqdi99pd 223 19 an an DT cord-015365-iqdi99pd 223 20 endochondral endochondral JJ cord-015365-iqdi99pd 223 21 ossification ossification NN cord-015365-iqdi99pd 223 22 process process NN cord-015365-iqdi99pd 223 23 with with IN cord-015365-iqdi99pd 223 24 subsequent subsequent JJ cord-015365-iqdi99pd 223 25 invasion invasion NN cord-015365-iqdi99pd 223 26 of of IN cord-015365-iqdi99pd 223 27 mouse mouse NN cord-015365-iqdi99pd 223 28 marrow marrow NN cord-015365-iqdi99pd 223 29 . . . cord-015365-iqdi99pd 224 1 These these DT cord-015365-iqdi99pd 224 2 results result NNS cord-015365-iqdi99pd 224 3 correlate correlate VBP cord-015365-iqdi99pd 224 4 with with IN cord-015365-iqdi99pd 224 5 the the DT cord-015365-iqdi99pd 224 6 epigenetic epigenetic JJ cord-015365-iqdi99pd 224 7 status status NN cord-015365-iqdi99pd 224 8 of of IN cord-015365-iqdi99pd 224 9 the the DT cord-015365-iqdi99pd 224 10 cells cell NNS cord-015365-iqdi99pd 224 11 since since IN cord-015365-iqdi99pd 224 12 BM bm NN cord-015365-iqdi99pd 224 13 - - HYPH cord-015365-iqdi99pd 224 14 derived derive VBN cord-015365-iqdi99pd 224 15 MSPCs mspc NNS cord-015365-iqdi99pd 224 16 cluster cluster NN cord-015365-iqdi99pd 224 17 separately separately RB cord-015365-iqdi99pd 224 18 in in IN cord-015365-iqdi99pd 224 19 principalcomponent principalcomponent NN cord-015365-iqdi99pd 224 20 - - HYPH cord-015365-iqdi99pd 224 21 analysis analysis NN cord-015365-iqdi99pd 224 22 ( ( -LRB- cord-015365-iqdi99pd 224 23 PCA PCA NNP cord-015365-iqdi99pd 224 24 ) ) -RRB- cord-015365-iqdi99pd 224 25 , , , cord-015365-iqdi99pd 224 26 whereas whereas IN cord-015365-iqdi99pd 224 27 MSPCs mspc NNS cord-015365-iqdi99pd 224 28 from from IN cord-015365-iqdi99pd 224 29 all all DT cord-015365-iqdi99pd 224 30 other other JJ cord-015365-iqdi99pd 224 31 tissues tissue NNS cord-015365-iqdi99pd 224 32 cluster cluster VB cord-015365-iqdi99pd 224 33 together together RB cord-015365-iqdi99pd 224 34 . . . cord-015365-iqdi99pd 225 1 BM BM NNP cord-015365-iqdi99pd 225 2 was be VBD cord-015365-iqdi99pd 225 3 the the DT cord-015365-iqdi99pd 225 4 only only JJ cord-015365-iqdi99pd 225 5 tissue tissue NN cord-015365-iqdi99pd 225 6 containing contain VBG cord-015365-iqdi99pd 225 7 MSPCs mspc NNS cord-015365-iqdi99pd 225 8 with with IN cord-015365-iqdi99pd 225 9 multipotent multipotent JJ cord-015365-iqdi99pd 225 10 differentiation differentiation NN cord-015365-iqdi99pd 225 11 capacity capacity NN cord-015365-iqdi99pd 225 12 . . . cord-015365-iqdi99pd 226 1 This this DT cord-015365-iqdi99pd 226 2 is be VBZ cord-015365-iqdi99pd 226 3 reflected reflect VBN cord-015365-iqdi99pd 226 4 by by IN cord-015365-iqdi99pd 226 5 a a DT cord-015365-iqdi99pd 226 6 BMspecific BMspecific NNP cord-015365-iqdi99pd 226 7 epigenetic epigenetic JJ cord-015365-iqdi99pd 226 8 profile profile NN cord-015365-iqdi99pd 226 9 that that WDT cord-015365-iqdi99pd 226 10 differs differ VBZ cord-015365-iqdi99pd 226 11 from from IN cord-015365-iqdi99pd 226 12 all all DT cord-015365-iqdi99pd 226 13 other other JJ cord-015365-iqdi99pd 226 14 tissues tissue NNS cord-015365-iqdi99pd 226 15 analyzed analyze VBN cord-015365-iqdi99pd 226 16 . . . cord-015365-iqdi99pd 227 1 Since since IN cord-015365-iqdi99pd 227 2 cartilage cartilage NN cord-015365-iqdi99pd 227 3 formation formation NN cord-015365-iqdi99pd 227 4 is be VBZ cord-015365-iqdi99pd 227 5 an an DT cord-015365-iqdi99pd 227 6 essential essential JJ cord-015365-iqdi99pd 227 7 developmental developmental JJ cord-015365-iqdi99pd 227 8 process process NN cord-015365-iqdi99pd 227 9 important important JJ cord-015365-iqdi99pd 227 10 for for IN cord-015365-iqdi99pd 227 11 bone bone NN cord-015365-iqdi99pd 227 12 generation generation NN cord-015365-iqdi99pd 227 13 and and CC cord-015365-iqdi99pd 227 14 hematopoiesis hematopoiesis NN cord-015365-iqdi99pd 227 15 attraction attraction NN cord-015365-iqdi99pd 227 16 , , , cord-015365-iqdi99pd 227 17 an an DT cord-015365-iqdi99pd 227 18 epigenetic epigenetic JJ cord-015365-iqdi99pd 227 19 predisposition predisposition NN cord-015365-iqdi99pd 227 20 of of IN cord-015365-iqdi99pd 227 21 BM BM NNP cord-015365-iqdi99pd 227 22 - - HYPH cord-015365-iqdi99pd 227 23 MSPCs mspc NNS cord-015365-iqdi99pd 227 24 to to TO cord-015365-iqdi99pd 227 25 undergo undergo VB cord-015365-iqdi99pd 227 26 endochondral endochondral JJ cord-015365-iqdi99pd 227 27 ossification ossification NN cord-015365-iqdi99pd 227 28 makes make VBZ cord-015365-iqdi99pd 227 29 these these DT cord-015365-iqdi99pd 227 30 cells cell NNS cord-015365-iqdi99pd 227 31 unique unique JJ cord-015365-iqdi99pd 227 32 for for IN cord-015365-iqdi99pd 227 33 bone bone NN cord-015365-iqdi99pd 227 34 and and CC cord-015365-iqdi99pd 227 35 marrow marrow NN cord-015365-iqdi99pd 227 36 regeneration regeneration NN cord-015365-iqdi99pd 227 37 purposes purpose NNS cord-015365-iqdi99pd 227 38 . . . cord-015365-iqdi99pd 228 1 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 228 2 . . . cord-015365-iqdi99pd 229 1 Die die VB cord-015365-iqdi99pd 230 1 Hemmung Hemmung NNP cord-015365-iqdi99pd 230 2 des des NNP cord-015365-iqdi99pd 230 3 Renin Renin NNP cord-015365-iqdi99pd 230 4 - - HYPH cord-015365-iqdi99pd 230 5 Angiotensin Angiotensin NNP cord-015365-iqdi99pd 230 6 - - HYPH cord-015365-iqdi99pd 230 7 Systems Systems NNP cord-015365-iqdi99pd 230 8 ( ( -LRB- cord-015365-iqdi99pd 230 9 RAS RAS NNP cord-015365-iqdi99pd 230 10 ) ) -RRB- cord-015365-iqdi99pd 230 11 entweder entweder NNP cord-015365-iqdi99pd 230 12 mit mit NNP cord-015365-iqdi99pd 230 13 ACE ACE NNP cord-015365-iqdi99pd 230 14 - - HYPH cord-015365-iqdi99pd 230 15 Hemmern Hemmern NNP cord-015365-iqdi99pd 230 16 oder oder NNP cord-015365-iqdi99pd 230 17 mit mit NNP cord-015365-iqdi99pd 230 18 Angiotensin Angiotensin NNP cord-015365-iqdi99pd 230 19 - - HYPH cord-015365-iqdi99pd 230 20 Rezeptor Rezeptor NNP cord-015365-iqdi99pd 230 21 - - HYPH cord-015365-iqdi99pd 230 22 Blockern Blockern NNP cord-015365-iqdi99pd 230 23 ( ( -LRB- cord-015365-iqdi99pd 230 24 ARB ARB NNP cord-015365-iqdi99pd 230 25 ) ) -RRB- cord-015365-iqdi99pd 230 26 verlangsamt verlangsamt NNP cord-015365-iqdi99pd 230 27 die die VBP cord-015365-iqdi99pd 231 1 Progression progression NN cord-015365-iqdi99pd 231 2 unterschiedlicher unterschiedlicher NN cord-015365-iqdi99pd 231 3 chronischer chronischer NNP cord-015365-iqdi99pd 232 1 Nierenerkrankungen Nierenerkrankungen NNP cord-015365-iqdi99pd 232 2 und und IN cord-015365-iqdi99pd 232 3 der der NNP cord-015365-iqdi99pd 232 4 chronischen chronischen NNP cord-015365-iqdi99pd 232 5 Transplantatdysfunktion Transplantatdysfunktion NNP cord-015365-iqdi99pd 232 6 . . . cord-015365-iqdi99pd 233 1 RAS RAS NNP cord-015365-iqdi99pd 233 2 - - HYPH cord-015365-iqdi99pd 233 3 Blockierung Blockierung NNP cord-015365-iqdi99pd 233 4 kann kann NNP cord-015365-iqdi99pd 234 1 auch auch NNP cord-015365-iqdi99pd 234 2 durch durch NNP cord-015365-iqdi99pd 235 1 eine eine NNP cord-015365-iqdi99pd 235 2 direkte direkte NNP cord-015365-iqdi99pd 235 3 Renin Renin NNP cord-015365-iqdi99pd 235 4 - - HYPH cord-015365-iqdi99pd 235 5 Inhibierung Inhibierung NNP cord-015365-iqdi99pd 235 6 erreicht erreicht NN cord-015365-iqdi99pd 235 7 werden werden NNP cord-015365-iqdi99pd 236 1 , , , cord-015365-iqdi99pd 236 2 die die VB cord-015365-iqdi99pd 236 3 aber aber NNP cord-015365-iqdi99pd 236 4 infolge infolge NNP cord-015365-iqdi99pd 236 5 einer einer NNP cord-015365-iqdi99pd 236 6 verminderten verminderten NNP cord-015365-iqdi99pd 236 7 Produktion Produktion NNP cord-015365-iqdi99pd 236 8 der der NN cord-015365-iqdi99pd 236 9 protektiven protektiven NNP cord-015365-iqdi99pd 237 1 Angiotensin angiotensin NN cord-015365-iqdi99pd 237 2 II II NNP cord-015365-iqdi99pd 238 1 -Spaltprodukte -Spaltprodukte : cord-015365-iqdi99pd 238 2 wie wie NNP cord-015365-iqdi99pd 238 3 z. z. NNP cord-015365-iqdi99pd 238 4 B. B. NNP cord-015365-iqdi99pd 238 5 Angiotensin Angiotensin NNP cord-015365-iqdi99pd 238 6 ( ( -LRB- cord-015365-iqdi99pd 238 7 Ang)(1 Ang)(1 NNP cord-015365-iqdi99pd 238 8 - - HYPH cord-015365-iqdi99pd 238 9 7 7 CD cord-015365-iqdi99pd 238 10 ) ) -RRB- cord-015365-iqdi99pd 238 11 zusätzliche zusätzliche NNP cord-015365-iqdi99pd 238 12 Effekte Effekte NNP cord-015365-iqdi99pd 238 13 haben haben NNP cord-015365-iqdi99pd 238 14 kann kann NNP cord-015365-iqdi99pd 238 15 . . . cord-015365-iqdi99pd 239 1 Methodik Methodik NNP cord-015365-iqdi99pd 239 2 . . . cord-015365-iqdi99pd 240 1 I -PRON- PRP cord-015365-iqdi99pd 241 1 m m NNP cord-015365-iqdi99pd 241 2 Fischer Fischer NNP cord-015365-iqdi99pd 241 3 - - HYPH cord-015365-iqdi99pd 241 4 Lewis Lewis NNP cord-015365-iqdi99pd 241 5 Nierentransplantationsmodell Nierentransplantationsmodell NNP cord-015365-iqdi99pd 241 6 der der NNP cord-015365-iqdi99pd 241 7 Ratte Ratte NNP cord-015365-iqdi99pd 241 8 wurde wurde NN cord-015365-iqdi99pd 241 9 der der NNP cord-015365-iqdi99pd 241 10 Effekt Effekt NNP cord-015365-iqdi99pd 241 11 von von NNP cord-015365-iqdi99pd 241 12 Aliskiren Aliskiren NNP cord-015365-iqdi99pd 241 13 ( ( -LRB- cord-015365-iqdi99pd 241 14 10 10 CD cord-015365-iqdi99pd 241 15 mg mg NNP cord-015365-iqdi99pd 241 16 / / SYM cord-015365-iqdi99pd 241 17 kg kg NNP cord-015365-iqdi99pd 241 18 / / SYM cord-015365-iqdi99pd 241 19 Tag tag NN cord-015365-iqdi99pd 241 20 ) ) -RRB- cord-015365-iqdi99pd 241 21 auf auf NN cord-015365-iqdi99pd 241 22 die die VBP cord-015365-iqdi99pd 242 1 Entstehung Entstehung NNP cord-015365-iqdi99pd 242 2 der der NNP cord-015365-iqdi99pd 243 1 chronischen chronischen NNP cord-015365-iqdi99pd 243 2 Transplantatdysfunktion Transplantatdysfunktion NNP cord-015365-iqdi99pd 244 1 i i PRP cord-015365-iqdi99pd 245 1 m m NNP cord-015365-iqdi99pd 245 2 Vergleich Vergleich NNP cord-015365-iqdi99pd 246 1 zu zu NNP cord-015365-iqdi99pd 247 1 einer einer NNP cord-015365-iqdi99pd 247 2 Behandlung Behandlung NNP cord-015365-iqdi99pd 247 3 mit mit NNP cord-015365-iqdi99pd 247 4 Vehikel Vehikel NNP cord-015365-iqdi99pd 247 5 oder oder NNP cord-015365-iqdi99pd 247 6 mit mit NNP cord-015365-iqdi99pd 247 7 dem dem NNP cord-015365-iqdi99pd 247 8 ARB ARB NNP cord-015365-iqdi99pd 247 9 Candesartan Candesartan NNP cord-015365-iqdi99pd 247 10 als als NN cord-015365-iqdi99pd 247 11 bekannter bekannter NN cord-015365-iqdi99pd 247 12 Hemmer Hemmer NNP cord-015365-iqdi99pd 247 13 der der NNP cord-015365-iqdi99pd 247 14 chronischen chronischen NNP cord-015365-iqdi99pd 247 15 Transplantatdysfunktion Transplantatdysfunktion NNP cord-015365-iqdi99pd 247 16 untersucht untersucht NN cord-015365-iqdi99pd 247 17 . . . cord-015365-iqdi99pd 248 1 Analysiert Analysiert NNP cord-015365-iqdi99pd 248 2 wurden wurden NNS cord-015365-iqdi99pd 248 3 die die VBP cord-015365-iqdi99pd 249 1 Histologie Histologie NNP cord-015365-iqdi99pd 249 2 der der VB cord-015365-iqdi99pd 249 3 Niere Niere NNP cord-015365-iqdi99pd 250 1 und und NNP cord-015365-iqdi99pd 250 2 der der NNP cord-015365-iqdi99pd 250 3 Verlauf Verlauf NNP cord-015365-iqdi99pd 250 4 der der NNP cord-015365-iqdi99pd 250 5 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 250 6 , , , cord-015365-iqdi99pd 250 7 der der NNP cord-015365-iqdi99pd 250 8 Serum Serum NNP cord-015365-iqdi99pd 250 9 - - HYPH cord-015365-iqdi99pd 250 10 Spiegel Spiegel NNP cord-015365-iqdi99pd 250 11 von von NNP cord-015365-iqdi99pd 250 12 Ang Ang NNP cord-015365-iqdi99pd 250 13 ( ( -LRB- cord-015365-iqdi99pd 250 14 1 1 CD cord-015365-iqdi99pd 250 15 - - SYM cord-015365-iqdi99pd 250 16 7 7 CD cord-015365-iqdi99pd 250 17 ) ) -RRB- cord-015365-iqdi99pd 250 18 und und NNP cord-015365-iqdi99pd 250 19 der der NNP cord-015365-iqdi99pd 250 20 Spiegel Spiegel NNP cord-015365-iqdi99pd 250 21 von von NNP cord-015365-iqdi99pd 250 22 Angiotensinogen Angiotensinogen NNP cord-015365-iqdi99pd 251 1 i -PRON- PRP cord-015365-iqdi99pd 251 2 m be VBP cord-015365-iqdi99pd 251 3 Harn Harn NNP cord-015365-iqdi99pd 251 4 als als NNP cord-015365-iqdi99pd 251 5 Indikator Indikator NNP cord-015365-iqdi99pd 251 6 für für NNS cord-015365-iqdi99pd 251 7 die die VBP cord-015365-iqdi99pd 251 8 intrarenale intrarenale NNP cord-015365-iqdi99pd 251 9 RAS RAS NNP cord-015365-iqdi99pd 251 10 - - HYPH cord-015365-iqdi99pd 251 11 Aktivität Aktivität NNP cord-015365-iqdi99pd 251 12 . . . cord-015365-iqdi99pd 252 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 252 2 . . . cord-015365-iqdi99pd 253 1 I -PRON- PRP cord-015365-iqdi99pd 254 1 m m LS cord-015365-iqdi99pd 254 2 Gegensatz Gegensatz NNP cord-015365-iqdi99pd 254 3 zu zu NNP cord-015365-iqdi99pd 254 4 Candesartan Candesartan NNP cord-015365-iqdi99pd 254 5 verminderte verminderte NN cord-015365-iqdi99pd 254 6 Aliskiren Aliskiren NNP cord-015365-iqdi99pd 254 7 weder weder NNP cord-015365-iqdi99pd 254 8 die die VB cord-015365-iqdi99pd 254 9 klinischen klinischen NNP cord-015365-iqdi99pd 254 10 ( ( -LRB- cord-015365-iqdi99pd 255 1 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 255 2 , , , cord-015365-iqdi99pd 255 3 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 255 4 - - HYPH cord-015365-iqdi99pd 255 5 Clearence Clearence NNP cord-015365-iqdi99pd 255 6 ) ) -RRB- cord-015365-iqdi99pd 255 7 noch noch NNP cord-015365-iqdi99pd 255 8 die die NNP cord-015365-iqdi99pd 256 1 histologischen histologischen NNP cord-015365-iqdi99pd 256 2 Zeichen Zeichen NNP cord-015365-iqdi99pd 256 3 ( ( -LRB- cord-015365-iqdi99pd 256 4 Glomerulosclerose Glomerulosclerose NNP cord-015365-iqdi99pd 256 5 , , , cord-015365-iqdi99pd 256 6 interstitielle interstitielle NNP cord-015365-iqdi99pd 256 7 Fibrose Fibrose NNP cord-015365-iqdi99pd 256 8 , , , cord-015365-iqdi99pd 256 9 Makrophagen Makrophagen NNP cord-015365-iqdi99pd 256 10 - - HYPH cord-015365-iqdi99pd 256 11 Infiltration Infiltration NNP cord-015365-iqdi99pd 256 12 ) ) -RRB- cord-015365-iqdi99pd 256 13 der der NNP cord-015365-iqdi99pd 256 14 chronischen chronischen NNP cord-015365-iqdi99pd 256 15 Transplantatdysfunktion Transplantatdysfunktion NNP cord-015365-iqdi99pd 256 16 . . . cord-015365-iqdi99pd 257 1 Candesartan Candesartan NNP cord-015365-iqdi99pd 257 2 verbesserte verbesserte NNP cord-015365-iqdi99pd 258 1 i i PRP cord-015365-iqdi99pd 259 1 m m NNP cord-015365-iqdi99pd 259 2 Vergleich Vergleich NNP cord-015365-iqdi99pd 260 1 zu zu NNP cord-015365-iqdi99pd 261 1 Vehikel Vehikel NNP cord-015365-iqdi99pd 261 2 - - HYPH cord-015365-iqdi99pd 261 3 und und NNP cord-015365-iqdi99pd 262 1 Aliskiren Aliskiren NNP cord-015365-iqdi99pd 262 2 - - HYPH cord-015365-iqdi99pd 262 3 behandelten behandelten NNP cord-015365-iqdi99pd 262 4 Gruppen Gruppen NNP cord-015365-iqdi99pd 262 5 sowohl sowohl NNP cord-015365-iqdi99pd 262 6 die die VBP cord-015365-iqdi99pd 262 7 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 262 8 als als NN cord-015365-iqdi99pd 262 9 auch auch JJ cord-015365-iqdi99pd 262 10 den den NNP cord-015365-iqdi99pd 262 11 Histologieschaden Histologieschaden NNP cord-015365-iqdi99pd 262 12 . . . cord-015365-iqdi99pd 263 1 Die die VB cord-015365-iqdi99pd 263 2 mit mit NNP cord-015365-iqdi99pd 263 3 Aliskiren Aliskiren NNP cord-015365-iqdi99pd 263 4 behandelten behandelten NNP cord-015365-iqdi99pd 263 5 Ratten Ratten NNP cord-015365-iqdi99pd 263 6 zeigten zeigten NNP cord-015365-iqdi99pd 264 1 einen einen NNP cord-015365-iqdi99pd 264 2 verminderten verminderten NNP cord-015365-iqdi99pd 264 3 Serum Serum NNP cord-015365-iqdi99pd 264 4 - - HYPH cord-015365-iqdi99pd 264 5 Spiegel Spiegel NNP cord-015365-iqdi99pd 264 6 des des FW cord-015365-iqdi99pd 264 7 protektiven protektiven NNP cord-015365-iqdi99pd 264 8 Ang(1 Ang(1 NNP cord-015365-iqdi99pd 264 9 - - HYPH cord-015365-iqdi99pd 264 10 7 7 NNP cord-015365-iqdi99pd 264 11 ) ) -RRB- cord-015365-iqdi99pd 264 12 und und RB cord-015365-iqdi99pd 265 1 einen einen NNP cord-015365-iqdi99pd 265 2 höheren höheren NNP cord-015365-iqdi99pd 265 3 Harn Harn NNP cord-015365-iqdi99pd 265 4 - - HYPH cord-015365-iqdi99pd 265 5 Angiotensinogen Angiotensinogen NNP cord-015365-iqdi99pd 265 6 - - HYPH cord-015365-iqdi99pd 265 7 Spiegel Spiegel NNP cord-015365-iqdi99pd 266 1 i -PRON- PRP cord-015365-iqdi99pd 266 2 m be VBP cord-015365-iqdi99pd 266 3 Vergleich Vergleich NNP cord-015365-iqdi99pd 266 4 zu zu NNP cord-015365-iqdi99pd 266 5 den den NNP cord-015365-iqdi99pd 266 6 mit mit NNP cord-015365-iqdi99pd 266 7 Candesartan Candesartan NNP cord-015365-iqdi99pd 266 8 behandelten behandelten NNP cord-015365-iqdi99pd 266 9 Tieren Tieren NNP cord-015365-iqdi99pd 266 10 . . . cord-015365-iqdi99pd 267 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 267 2 . . . cord-015365-iqdi99pd 268 1 Der Der NNP cord-015365-iqdi99pd 268 2 Renin Renin NNP cord-015365-iqdi99pd 268 3 - - HYPH cord-015365-iqdi99pd 268 4 Blocker Blocker NNP cord-015365-iqdi99pd 268 5 Aliskiren Aliskiren NNP cord-015365-iqdi99pd 268 6 verminderte verminderte NN cord-015365-iqdi99pd 268 7 das das NNP cord-015365-iqdi99pd 268 8 Fortschreiten Fortschreiten NNP cord-015365-iqdi99pd 268 9 der der NNP cord-015365-iqdi99pd 268 10 chronischen chronischen FW cord-015365-iqdi99pd 268 11 Transplantatdysfunktion Transplantatdysfunktion NNP cord-015365-iqdi99pd 268 12 nicht nicht NNP cord-015365-iqdi99pd 268 13 . . . cord-015365-iqdi99pd 269 1 Der Der NNP cord-015365-iqdi99pd 269 2 fehlende fehlende NNP cord-015365-iqdi99pd 269 3 Schutzeffekt Schutzeffekt NNP cord-015365-iqdi99pd 269 4 hängt hängt NNP cord-015365-iqdi99pd 269 5 wahrscheinlich wahrscheinlich NNP cord-015365-iqdi99pd 269 6 entweder entweder NNP cord-015365-iqdi99pd 269 7 mit mit NNP cord-015365-iqdi99pd 269 8 der der NNP cord-015365-iqdi99pd 269 9 verminderten verminderten NNP cord-015365-iqdi99pd 269 10 Produktion Produktion NNP cord-015365-iqdi99pd 269 11 des des FW cord-015365-iqdi99pd 269 12 protektiven protektiven NN cord-015365-iqdi99pd 270 1 Ang(1 Ang(1 NNP cord-015365-iqdi99pd 270 2 - - HYPH cord-015365-iqdi99pd 270 3 7 7 CD cord-015365-iqdi99pd 270 4 ) ) -RRB- cord-015365-iqdi99pd 271 1 oder oder NNP cord-015365-iqdi99pd 271 2 mit mit NNP cord-015365-iqdi99pd 271 3 einer einer NNP cord-015365-iqdi99pd 271 4 ineffektiven ineffektiven NNP cord-015365-iqdi99pd 271 5 intrarenalen intrarenalen NNP cord-015365-iqdi99pd 271 6 RAS RAS NNP cord-015365-iqdi99pd 271 7 - - HYPH cord-015365-iqdi99pd 271 8 Blockierung Blockierung NNP cord-015365-iqdi99pd 271 9 zusammen zusammen NNP cord-015365-iqdi99pd 271 10 . . . cord-015365-iqdi99pd 272 1 Kein Kein NNP cord-015365-iqdi99pd 272 2 Unterschied Unterschied NNP cord-015365-iqdi99pd 272 3 i -PRON- PRP cord-015365-iqdi99pd 272 4 m be VBP cord-015365-iqdi99pd 272 5 Gehalt Gehalt NNP cord-015365-iqdi99pd 273 1 an an DT cord-015365-iqdi99pd 273 2 energiereichen energiereichen NNP cord-015365-iqdi99pd 273 3 Phosphaten Phosphaten NNP cord-015365-iqdi99pd 273 4 in in IN cord-015365-iqdi99pd 273 5 Organen Organen NNP cord-015365-iqdi99pd 273 6 von von NNP cord-015365-iqdi99pd 273 7 Lebendspendern Lebendspendern NNP cord-015365-iqdi99pd 273 8 , , , cord-015365-iqdi99pd 273 9 hirntoten hirntoten VBN cord-015365-iqdi99pd 273 10 Spendern Spendern NNP cord-015365-iqdi99pd 273 11 und und IN cord-015365-iqdi99pd 273 12 " " `` cord-015365-iqdi99pd 273 13 non non JJ cord-015365-iqdi99pd 273 14 - - JJ cord-015365-iqdi99pd 273 15 heartbeating heartbeating JJ cord-015365-iqdi99pd 273 16 " " `` cord-015365-iqdi99pd 273 17 Spendern Spendern NNP cord-015365-iqdi99pd 273 18 i -PRON- PRP cord-015365-iqdi99pd 273 19 m be VBP cord-015365-iqdi99pd 273 20 Tiermodell Tiermodell NNP cord-015365-iqdi99pd 273 21 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 273 22 . . . cord-015365-iqdi99pd 274 1 Zusammenfassend Zusammenfassend NNP cord-015365-iqdi99pd 274 2 sind sind NN cord-015365-iqdi99pd 274 3 unterschiedliche unterschiedliche NN cord-015365-iqdi99pd 275 1 miRNA miRNA NNP cord-015365-iqdi99pd 275 2 - - HYPH cord-015365-iqdi99pd 275 3 Signaturen Signaturen NNP cord-015365-iqdi99pd 275 4 mit mit NNP cord-015365-iqdi99pd 275 5 zellulärer zellulärer NNP cord-015365-iqdi99pd 275 6 oder oder NNP cord-015365-iqdi99pd 275 7 humoraler humoraler NNP cord-015365-iqdi99pd 275 8 Abstoßung Abstoßung NNP cord-015365-iqdi99pd 275 9 sowie sowie NNP cord-015365-iqdi99pd 275 10 DGF DGF NNP cord-015365-iqdi99pd 275 11 assoziiert assoziiert NNP cord-015365-iqdi99pd 275 12 . . . cord-015365-iqdi99pd 276 1 Die die VB cord-015365-iqdi99pd 276 2 identifizierten identifizierten NNP cord-015365-iqdi99pd 276 3 miRNAs miRNAs NNP cord-015365-iqdi99pd 276 4 und und IN cord-015365-iqdi99pd 276 5 Target Target NNP cord-015365-iqdi99pd 276 6 - - HYPH cord-015365-iqdi99pd 276 7 Gene Gene NNP cord-015365-iqdi99pd 276 8 werden werden NNP cord-015365-iqdi99pd 276 9 neue neue NNP cord-015365-iqdi99pd 277 1 Sichtweisen Sichtweisen NNP cord-015365-iqdi99pd 277 2 auf auf NNP cord-015365-iqdi99pd 277 3 die die NNP cord-015365-iqdi99pd 277 4 molekulare molekulare NNP cord-015365-iqdi99pd 278 1 Regulation regulation NN cord-015365-iqdi99pd 278 2 von von NNP cord-015365-iqdi99pd 278 3 Transplantatabstoßung Transplantatabstoßung NNP cord-015365-iqdi99pd 278 4 und und IN cord-015365-iqdi99pd 278 5 Transplantatversagen Transplantatversagen NNP cord-015365-iqdi99pd 278 6 erlauben erlauben NN cord-015365-iqdi99pd 278 7 und und XX cord-015365-iqdi99pd 278 8 so so RB cord-015365-iqdi99pd 279 1 den den NNP cord-015365-iqdi99pd 279 2 Weg Weg NNP cord-015365-iqdi99pd 279 3 für für IN cord-015365-iqdi99pd 279 4 neue neue NNP cord-015365-iqdi99pd 279 5 Therapieansätze Therapieansätze NNP cord-015365-iqdi99pd 279 6 ebnen ebnen NNP cord-015365-iqdi99pd 279 7 . . . cord-015365-iqdi99pd 280 1 Darüber Darüber NNP cord-015365-iqdi99pd 280 2 hinaus hinaus NNP cord-015365-iqdi99pd 280 3 könnten könnten RB cord-015365-iqdi99pd 280 4 die die VBP cord-015365-iqdi99pd 280 5 identifizierten identifizierten NNP cord-015365-iqdi99pd 280 6 miRNAs miRNAs NNP cord-015365-iqdi99pd 281 1 und und NNP cord-015365-iqdi99pd 281 2 Target Target NNP cord-015365-iqdi99pd 281 3 - - HYPH cord-015365-iqdi99pd 281 4 Proteine Proteine NNP cord-015365-iqdi99pd 281 5 in in IN cord-015365-iqdi99pd 281 6 Zukunft Zukunft NNP cord-015365-iqdi99pd 281 7 als als CD cord-015365-iqdi99pd 281 8 neue neue NNP cord-015365-iqdi99pd 281 9 diagnostische diagnostische IN cord-015365-iqdi99pd 281 10 Marker Marker NNP cord-015365-iqdi99pd 281 11 eingesetzt eingesetzt VBD cord-015365-iqdi99pd 281 12 werden werden NNP cord-015365-iqdi99pd 281 13 . . . cord-015365-iqdi99pd 282 1 Correlation correlation NN cord-015365-iqdi99pd 282 2 of of IN cord-015365-iqdi99pd 282 3 recipient recipient NN cord-015365-iqdi99pd 282 4 factors factor NNS cord-015365-iqdi99pd 282 5 with with IN cord-015365-iqdi99pd 282 6 the the DT cord-015365-iqdi99pd 282 7 course course NN cord-015365-iqdi99pd 282 8 of of IN cord-015365-iqdi99pd 282 9 lymphocytes lymphocyte NNS cord-015365-iqdi99pd 282 10 after after IN cord-015365-iqdi99pd 282 11 alemtuzumab alemtuzumab JJ cord-015365-iqdi99pd 282 12 induction induction NN cord-015365-iqdi99pd 282 13 in in IN cord-015365-iqdi99pd 282 14 renal renal JJ cord-015365-iqdi99pd 282 15 transplantation transplantation NN cord-015365-iqdi99pd 282 16 Background background NN cord-015365-iqdi99pd 282 17 . . . cord-015365-iqdi99pd 283 1 Alemtuzumab Alemtuzumab NNP cord-015365-iqdi99pd 283 2 , , , cord-015365-iqdi99pd 283 3 an an DT cord-015365-iqdi99pd 283 4 anti anti JJ cord-015365-iqdi99pd 283 5 - - JJ cord-015365-iqdi99pd 283 6 CD52 cd52 JJ cord-015365-iqdi99pd 283 7 T t NN cord-015365-iqdi99pd 283 8 - - HYPH cord-015365-iqdi99pd 283 9 cell cell NN cord-015365-iqdi99pd 283 10 and and CC cord-015365-iqdi99pd 283 11 B b NN cord-015365-iqdi99pd 283 12 - - HYPH cord-015365-iqdi99pd 283 13 cell cell NN cord-015365-iqdi99pd 283 14 depleting deplete VBG cord-015365-iqdi99pd 283 15 monoclonal monoclonal JJ cord-015365-iqdi99pd 283 16 antibody antibody NN cord-015365-iqdi99pd 283 17 , , , cord-015365-iqdi99pd 283 18 used use VBN cord-015365-iqdi99pd 283 19 as as IN cord-015365-iqdi99pd 283 20 induction induction NN cord-015365-iqdi99pd 283 21 therapy therapy NN cord-015365-iqdi99pd 283 22 in in IN cord-015365-iqdi99pd 283 23 renal renal JJ cord-015365-iqdi99pd 283 24 transplantation transplantation NN cord-015365-iqdi99pd 283 25 ( ( -LRB- cord-015365-iqdi99pd 283 26 KTs kts NN cord-015365-iqdi99pd 283 27 ) ) -RRB- cord-015365-iqdi99pd 283 28 . . . cord-015365-iqdi99pd 284 1 The the DT cord-015365-iqdi99pd 284 2 recovery recovery NN cord-015365-iqdi99pd 284 3 of of IN cord-015365-iqdi99pd 284 4 lymphocytes lymphocyte NNS cord-015365-iqdi99pd 284 5 after after IN cord-015365-iqdi99pd 284 6 alemtuzumab alemtuzumab JJ cord-015365-iqdi99pd 284 7 induction induction NN cord-015365-iqdi99pd 284 8 has have VBZ cord-015365-iqdi99pd 284 9 been be VBN cord-015365-iqdi99pd 284 10 investigated investigate VBN cord-015365-iqdi99pd 284 11 in in IN cord-015365-iqdi99pd 284 12 a a DT cord-015365-iqdi99pd 284 13 number number NN cord-015365-iqdi99pd 284 14 of of IN cord-015365-iqdi99pd 284 15 trials trial NNS cord-015365-iqdi99pd 284 16 , , , cord-015365-iqdi99pd 284 17 however however RB cord-015365-iqdi99pd 284 18 , , , cord-015365-iqdi99pd 284 19 the the DT cord-015365-iqdi99pd 284 20 clinical clinical JJ cord-015365-iqdi99pd 284 21 course course NN cord-015365-iqdi99pd 284 22 after after IN cord-015365-iqdi99pd 284 23 KTx KTx NNS cord-015365-iqdi99pd 284 24 has have VBZ cord-015365-iqdi99pd 284 25 not not RB cord-015365-iqdi99pd 284 26 been be VBN cord-015365-iqdi99pd 284 27 correlated correlate VBN cord-015365-iqdi99pd 284 28 with with IN cord-015365-iqdi99pd 284 29 lymphocyte lymphocyte NN cord-015365-iqdi99pd 284 30 recovery recovery NN cord-015365-iqdi99pd 284 31 . . . cord-015365-iqdi99pd 285 1 Herein herein RB cord-015365-iqdi99pd 285 2 , , , cord-015365-iqdi99pd 285 3 we -PRON- PRP cord-015365-iqdi99pd 285 4 correlate correlate VBP cord-015365-iqdi99pd 285 5 the the DT cord-015365-iqdi99pd 285 6 outcome outcome NN cord-015365-iqdi99pd 285 7 as as RB cord-015365-iqdi99pd 285 8 well well RB cord-015365-iqdi99pd 285 9 as as IN cord-015365-iqdi99pd 285 10 recipient recipient NN cord-015365-iqdi99pd 285 11 factors factor NNS cord-015365-iqdi99pd 285 12 with with IN cord-015365-iqdi99pd 285 13 lymphocyte lymphocyte NN cord-015365-iqdi99pd 285 14 recovery recovery NN cord-015365-iqdi99pd 285 15 after after IN cord-015365-iqdi99pd 285 16 induction induction NN cord-015365-iqdi99pd 285 17 with with IN cord-015365-iqdi99pd 285 18 alemtuzumab alemtuzumab NNS cord-015365-iqdi99pd 285 19 . . . cord-015365-iqdi99pd 286 1 Methods method NNS cord-015365-iqdi99pd 286 2 . . . cord-015365-iqdi99pd 287 1 Single single JJ cord-015365-iqdi99pd 287 2 center center NN cord-015365-iqdi99pd 287 3 retrospective retrospective JJ cord-015365-iqdi99pd 287 4 analysis analysis NN cord-015365-iqdi99pd 287 5 of of IN cord-015365-iqdi99pd 287 6 225 225 CD cord-015365-iqdi99pd 287 7 patients patient NNS cord-015365-iqdi99pd 287 8 / / SYM cord-015365-iqdi99pd 287 9 consecutive consecutive JJ cord-015365-iqdi99pd 287 10 kidney kidney NN cord-015365-iqdi99pd 287 11 transplantations transplantation NNS cord-015365-iqdi99pd 287 12 between between IN cord-015365-iqdi99pd 287 13 01/ 01/ CD cord-015365-iqdi99pd 287 14 2004 2004 CD cord-015365-iqdi99pd 287 15 and and CC cord-015365-iqdi99pd 287 16 12/2010 12/2010 CD cord-015365-iqdi99pd 287 17 which which WDT cord-015365-iqdi99pd 287 18 received receive VBD cord-015365-iqdi99pd 287 19 alemtuzumab alemtuzumab NNP cord-015365-iqdi99pd 287 20 as as IN cord-015365-iqdi99pd 287 21 induction induction NN cord-015365-iqdi99pd 287 22 agent agent NN cord-015365-iqdi99pd 287 23 ( ( -LRB- cord-015365-iqdi99pd 287 24 one one CD cord-015365-iqdi99pd 287 25 dose dose NN cord-015365-iqdi99pd 287 26 of of IN cord-015365-iqdi99pd 287 27 30 30 CD cord-015365-iqdi99pd 287 28 mg mg NN cord-015365-iqdi99pd 287 29 ) ) -RRB- cord-015365-iqdi99pd 287 30 . . . cord-015365-iqdi99pd 288 1 Patients patient NNS cord-015365-iqdi99pd 288 2 were be VBD cord-015365-iqdi99pd 288 3 devided devide VBN cord-015365-iqdi99pd 288 4 into into IN cord-015365-iqdi99pd 288 5 4 4 CD cord-015365-iqdi99pd 288 6 groups group NNS cord-015365-iqdi99pd 288 7 according accord VBG cord-015365-iqdi99pd 288 8 to to IN cord-015365-iqdi99pd 288 9 lymphocyte lymphocyte NN cord-015365-iqdi99pd 288 10 recovery recovery NN cord-015365-iqdi99pd 288 11 at at IN cord-015365-iqdi99pd 288 12 4 4 CD cord-015365-iqdi99pd 288 13 points point NNS cord-015365-iqdi99pd 288 14 of of IN cord-015365-iqdi99pd 288 15 time time NN cord-015365-iqdi99pd 288 16 ( ( -LRB- cord-015365-iqdi99pd 288 17 pre pre NNP cord-015365-iqdi99pd 288 18 - - NNP cord-015365-iqdi99pd 288 19 Tx Tx NNP cord-015365-iqdi99pd 288 20 , , , cord-015365-iqdi99pd 288 21 1 1 CD cord-015365-iqdi99pd 288 22 - - SYM cord-015365-iqdi99pd 288 23 3 3 CD cord-015365-iqdi99pd 288 24 weeks week NNS cord-015365-iqdi99pd 288 25 post post NN cord-015365-iqdi99pd 288 26 - - NNP cord-015365-iqdi99pd 288 27 Tx Tx NNP cord-015365-iqdi99pd 288 28 , , , cord-015365-iqdi99pd 288 29 3 3 CD cord-015365-iqdi99pd 288 30 weeks-3 weeks-3 NNP cord-015365-iqdi99pd 288 31 months month NNS cord-015365-iqdi99pd 288 32 post post NNP cord-015365-iqdi99pd 288 33 - - NNP cord-015365-iqdi99pd 288 34 Tx Tx NNP cord-015365-iqdi99pd 288 35 and and CC cord-015365-iqdi99pd 288 36 3 3 CD cord-015365-iqdi99pd 288 37 - - SYM cord-015365-iqdi99pd 288 38 6 6 CD cord-015365-iqdi99pd 288 39 months month NNS cord-015365-iqdi99pd 288 40 after after IN cord-015365-iqdi99pd 288 41 KTx KTx NNS cord-015365-iqdi99pd 288 42 ) ) -RRB- cord-015365-iqdi99pd 288 43 . . . cord-015365-iqdi99pd 289 1 The the DT cord-015365-iqdi99pd 289 2 relevance relevance NN cord-015365-iqdi99pd 289 3 of of IN cord-015365-iqdi99pd 289 4 recipient recipient NN cord-015365-iqdi99pd 289 5 - - HYPH cord-015365-iqdi99pd 289 6 characteristics characteristic NNS cord-015365-iqdi99pd 289 7 was be VBD cord-015365-iqdi99pd 289 8 analyzed analyze VBN cord-015365-iqdi99pd 289 9 . . . cord-015365-iqdi99pd 290 1 Delayed delay VBN cord-015365-iqdi99pd 290 2 kidney kidney NN cord-015365-iqdi99pd 290 3 graft graft NN cord-015365-iqdi99pd 290 4 function function NN cord-015365-iqdi99pd 290 5 ( ( -LRB- cord-015365-iqdi99pd 290 6 DGF DGF NNP cord-015365-iqdi99pd 290 7 ) ) -RRB- cord-015365-iqdi99pd 290 8 was be VBD cord-015365-iqdi99pd 290 9 defined define VBN cord-015365-iqdi99pd 290 10 as as IN cord-015365-iqdi99pd 290 11 requirement requirement NN cord-015365-iqdi99pd 290 12 for for IN cord-015365-iqdi99pd 290 13 more more JJR cord-015365-iqdi99pd 290 14 than than IN cord-015365-iqdi99pd 290 15 one one CD cord-015365-iqdi99pd 290 16 dialysis dialysis NN cord-015365-iqdi99pd 290 17 within within IN cord-015365-iqdi99pd 290 18 the the DT cord-015365-iqdi99pd 290 19 first first JJ cord-015365-iqdi99pd 290 20 week week NN cord-015365-iqdi99pd 290 21 after after IN cord-015365-iqdi99pd 290 22 KTx KTx NNS cord-015365-iqdi99pd 290 23 . . . cord-015365-iqdi99pd 291 1 Statistical statistical JJ cord-015365-iqdi99pd 291 2 analysis analysis NN cord-015365-iqdi99pd 291 3 was be VBD cord-015365-iqdi99pd 291 4 performed perform VBN cord-015365-iqdi99pd 291 5 with with IN cord-015365-iqdi99pd 291 6 SPSS SPSS NNP cord-015365-iqdi99pd 291 7 17.0 17.0 CD cord-015365-iqdi99pd 291 8 software software NN cord-015365-iqdi99pd 291 9 ( ( -LRB- cord-015365-iqdi99pd 291 10 SPSS SPSS NNP cord-015365-iqdi99pd 291 11 Inc. Inc. NNP cord-015365-iqdi99pd 291 12 , , , cord-015365-iqdi99pd 291 13 Chicago Chicago NNP cord-015365-iqdi99pd 291 14 , , , cord-015365-iqdi99pd 291 15 IL IL NNP cord-015365-iqdi99pd 291 16 , , , cord-015365-iqdi99pd 291 17 USA USA NNP cord-015365-iqdi99pd 291 18 ) ) -RRB- cord-015365-iqdi99pd 291 19 . . . cord-015365-iqdi99pd 292 1 Analysis analysis NN cord-015365-iqdi99pd 292 2 of of IN cord-015365-iqdi99pd 292 3 variance variance NN cord-015365-iqdi99pd 292 4 for for IN cord-015365-iqdi99pd 292 5 repeated repeat VBN cord-015365-iqdi99pd 292 6 measurements measurement NNS cord-015365-iqdi99pd 292 7 with with IN cord-015365-iqdi99pd 292 8 measurement measurement NN cord-015365-iqdi99pd 292 9 time time NN cord-015365-iqdi99pd 292 10 as as IN cord-015365-iqdi99pd 292 11 withinsubject withinsubject NN cord-015365-iqdi99pd 292 12 factor factor NN cord-015365-iqdi99pd 292 13 and and CC cord-015365-iqdi99pd 292 14 with with IN cord-015365-iqdi99pd 292 15 age age NN cord-015365-iqdi99pd 292 16 , , , cord-015365-iqdi99pd 292 17 CMV CMV NNP cord-015365-iqdi99pd 292 18 status status NN cord-015365-iqdi99pd 292 19 , , , cord-015365-iqdi99pd 292 20 DGF dgf NN cord-015365-iqdi99pd 292 21 status status NN cord-015365-iqdi99pd 292 22 as as IN cord-015365-iqdi99pd 292 23 between between IN cord-015365-iqdi99pd 292 24 subject subject JJ cord-015365-iqdi99pd 292 25 factors factor NNS cord-015365-iqdi99pd 292 26 were be VBD cord-015365-iqdi99pd 292 27 performed perform VBN cord-015365-iqdi99pd 292 28 . . . cord-015365-iqdi99pd 293 1 Results result NNS cord-015365-iqdi99pd 293 2 . . . cord-015365-iqdi99pd 294 1 Median median JJ cord-015365-iqdi99pd 294 2 age age NN cord-015365-iqdi99pd 294 3 of of IN cord-015365-iqdi99pd 294 4 all all DT cord-015365-iqdi99pd 294 5 recipients recipient NNS cord-015365-iqdi99pd 294 6 was be VBD cord-015365-iqdi99pd 294 7 49.63 49.63 CD cord-015365-iqdi99pd 294 8 years year NNS cord-015365-iqdi99pd 294 9 , , , cord-015365-iqdi99pd 294 10 65.33 65.33 CD cord-015365-iqdi99pd 294 11 % % NN cord-015365-iqdi99pd 294 12 were be VBD cord-015365-iqdi99pd 294 13 male male JJ cord-015365-iqdi99pd 294 14 . . . cord-015365-iqdi99pd 295 1 Mean mean JJ cord-015365-iqdi99pd 295 2 lymphocyte lymphocyte NN cord-015365-iqdi99pd 295 3 counts count NNS cord-015365-iqdi99pd 295 4 were be VBD cord-015365-iqdi99pd 295 5 22.8 22.8 CD cord-015365-iqdi99pd 295 6 AE AE NNP cord-015365-iqdi99pd 295 7 9.41 9.41 CD cord-015365-iqdi99pd 295 8 % % NN cord-015365-iqdi99pd 295 9 pre pre JJ cord-015365-iqdi99pd 295 10 - - NNP cord-015365-iqdi99pd 295 11 Tx Tx NNP cord-015365-iqdi99pd 295 12 , , , cord-015365-iqdi99pd 295 13 2.61 2.61 CD cord-015365-iqdi99pd 295 14 AE AE NNP cord-015365-iqdi99pd 295 15 3.11 3.11 CD cord-015365-iqdi99pd 295 16 % % NN cord-015365-iqdi99pd 295 17 between between IN cord-015365-iqdi99pd 295 18 week week NN cord-015365-iqdi99pd 295 19 1 1 CD cord-015365-iqdi99pd 295 20 and and CC cord-015365-iqdi99pd 295 21 3 3 CD cord-015365-iqdi99pd 295 22 , , , cord-015365-iqdi99pd 295 23 6.98 6.98 CD cord-015365-iqdi99pd 295 24 AE AE NNP cord-015365-iqdi99pd 295 25 6.7 6.7 CD cord-015365-iqdi99pd 295 26 % % NN cord-015365-iqdi99pd 295 27 between between IN cord-015365-iqdi99pd 295 28 3 3 CD cord-015365-iqdi99pd 295 29 weeks week NNS cord-015365-iqdi99pd 295 30 and and CC cord-015365-iqdi99pd 295 31 3 3 CD cord-015365-iqdi99pd 295 32 months month NNS cord-015365-iqdi99pd 295 33 after after IN cord-015365-iqdi99pd 295 34 Tx Tx NNP cord-015365-iqdi99pd 295 35 and and CC cord-015365-iqdi99pd 295 36 18.20 18.20 CD cord-015365-iqdi99pd 295 37 AE AE NNP cord-015365-iqdi99pd 295 38 11.48 11.48 CD cord-015365-iqdi99pd 295 39 % % NN cord-015365-iqdi99pd 295 40 at at IN cord-015365-iqdi99pd 295 41 later later JJ cord-015365-iqdi99pd 295 42 time time NN cord-015365-iqdi99pd 295 43 points point NNS cord-015365-iqdi99pd 295 44 . . . cord-015365-iqdi99pd 296 1 Among among IN cord-015365-iqdi99pd 296 2 all all DT cord-015365-iqdi99pd 296 3 factors factor NNS cord-015365-iqdi99pd 296 4 analyzed analyze VBN cord-015365-iqdi99pd 296 5 , , , cord-015365-iqdi99pd 296 6 DGF DGF NNP cord-015365-iqdi99pd 296 7 , , , cord-015365-iqdi99pd 296 8 CMV CMV NNP cord-015365-iqdi99pd 296 9 status status NN cord-015365-iqdi99pd 296 10 and and CC cord-015365-iqdi99pd 296 11 age age NN cord-015365-iqdi99pd 296 12 showed show VBD cord-015365-iqdi99pd 296 13 a a DT cord-015365-iqdi99pd 296 14 significant significant JJ cord-015365-iqdi99pd 296 15 correlation correlation NN cord-015365-iqdi99pd 296 16 with with IN cord-015365-iqdi99pd 296 17 lymphocyte lymphocyte NN cord-015365-iqdi99pd 296 18 counts count NNS cord-015365-iqdi99pd 296 19 . . . cord-015365-iqdi99pd 297 1 DGF DGF NNP cord-015365-iqdi99pd 297 2 occurred occur VBD cord-015365-iqdi99pd 297 3 in in IN cord-015365-iqdi99pd 297 4 27.56 27.56 CD cord-015365-iqdi99pd 297 5 % % NN cord-015365-iqdi99pd 297 6 of of IN cord-015365-iqdi99pd 297 7 the the DT cord-015365-iqdi99pd 297 8 recipients recipient NNS cord-015365-iqdi99pd 297 9 . . . cord-015365-iqdi99pd 298 1 The the DT cord-015365-iqdi99pd 298 2 lymphocyte lymphocyte NN cord-015365-iqdi99pd 298 3 - - HYPH cord-015365-iqdi99pd 298 4 counts count NNS cord-015365-iqdi99pd 298 5 in in IN cord-015365-iqdi99pd 298 6 the the DT cord-015365-iqdi99pd 298 7 DGFgroup dgfgroup NN cord-015365-iqdi99pd 298 8 were be VBD cord-015365-iqdi99pd 298 9 significantly significantly RB cord-015365-iqdi99pd 298 10 higher high JJR cord-015365-iqdi99pd 298 11 , , , cord-015365-iqdi99pd 298 12 10.7 10.7 CD cord-015365-iqdi99pd 298 13 % % NN cord-015365-iqdi99pd 298 14 vs. vs. IN cord-015365-iqdi99pd 298 15 13.13 13.13 CD cord-015365-iqdi99pd 298 16 % % NN cord-015365-iqdi99pd 299 1 ( ( -LRB- cord-015365-iqdi99pd 299 2 p p NN cord-015365-iqdi99pd 299 3 ¼ ¼ CD cord-015365-iqdi99pd 299 4 0.036 0.036 CD cord-015365-iqdi99pd 299 5 ) ) -RRB- cord-015365-iqdi99pd 300 1 post post NNP cord-015365-iqdi99pd 300 2 - - NNP cord-015365-iqdi99pd 300 3 Tx Tx NNP cord-015365-iqdi99pd 300 4 . . . cord-015365-iqdi99pd 301 1 CMV CMV NNP cord-015365-iqdi99pd 301 2 - - HYPH cord-015365-iqdi99pd 301 3 status status NN cord-015365-iqdi99pd 301 4 of of IN cord-015365-iqdi99pd 301 5 the the DT cord-015365-iqdi99pd 301 6 recipient recipient NN cord-015365-iqdi99pd 301 7 influences influence VBZ cord-015365-iqdi99pd 301 8 the the DT cord-015365-iqdi99pd 301 9 quantity quantity NN cord-015365-iqdi99pd 301 10 of of IN cord-015365-iqdi99pd 301 11 lymphocytes lymphocytes FW cord-015365-iqdi99pd 301 12 pre pre NNP cord-015365-iqdi99pd 301 13 - - NNP cord-015365-iqdi99pd 301 14 Tx Tx NNP cord-015365-iqdi99pd 301 15 significantly significantly RB cord-015365-iqdi99pd 301 16 ( ( -LRB- cord-015365-iqdi99pd 301 17 p p NN cord-015365-iqdi99pd 301 18 ¼ ¼ CD cord-015365-iqdi99pd 301 19 0.009 0.009 CD cord-015365-iqdi99pd 301 20 ) ) -RRB- cord-015365-iqdi99pd 301 21 . . . cord-015365-iqdi99pd 302 1 Age age NN cord-015365-iqdi99pd 302 2 showed show VBD cord-015365-iqdi99pd 302 3 a a DT cord-015365-iqdi99pd 302 4 significantly significantly JJ cord-015365-iqdi99pd 302 5 influence influence NN cord-015365-iqdi99pd 302 6 on on IN cord-015365-iqdi99pd 302 7 the the DT cord-015365-iqdi99pd 302 8 lymphocyte lymphocyte NN cord-015365-iqdi99pd 302 9 count count NN cord-015365-iqdi99pd 302 10 3 3 CD cord-015365-iqdi99pd 302 11 months month NNS cord-015365-iqdi99pd 302 12 post post NNP cord-015365-iqdi99pd 302 13 - - NNP cord-015365-iqdi99pd 302 14 Tx Tx NNP cord-015365-iqdi99pd 302 15 ( ( -LRB- cord-015365-iqdi99pd 302 16 p p NN cord-015365-iqdi99pd 302 17 ¼ ¼ CD cord-015365-iqdi99pd 302 18 0.032 0.032 CD cord-015365-iqdi99pd 302 19 ) ) -RRB- cord-015365-iqdi99pd 302 20 . . . cord-015365-iqdi99pd 303 1 Conclusions conclusion NNS cord-015365-iqdi99pd 303 2 . . . cord-015365-iqdi99pd 304 1 CMV CMV NNP cord-015365-iqdi99pd 304 2 - - HYPH cord-015365-iqdi99pd 304 3 status status NN cord-015365-iqdi99pd 304 4 and and CC cord-015365-iqdi99pd 304 5 age age NN cord-015365-iqdi99pd 304 6 have have VBP cord-015365-iqdi99pd 304 7 a a DT cord-015365-iqdi99pd 304 8 significant significant JJ cord-015365-iqdi99pd 304 9 impact impact NN cord-015365-iqdi99pd 304 10 on on IN cord-015365-iqdi99pd 304 11 lymphocyte lymphocyte NN cord-015365-iqdi99pd 304 12 recovery recovery NN cord-015365-iqdi99pd 304 13 after after IN cord-015365-iqdi99pd 304 14 alemtuzumab alemtuzumab NNP cord-015365-iqdi99pd 304 15 induction induction NN cord-015365-iqdi99pd 304 16 therapy therapy NN cord-015365-iqdi99pd 304 17 . . . cord-015365-iqdi99pd 305 1 Lymphocyte lymphocyte NN cord-015365-iqdi99pd 305 2 counts count VBZ cord-015365-iqdi99pd 305 3 early early RB cord-015365-iqdi99pd 305 4 after after IN cord-015365-iqdi99pd 305 5 transplantation transplantation NN cord-015365-iqdi99pd 305 6 represent represent VBP cord-015365-iqdi99pd 305 7 a a DT cord-015365-iqdi99pd 305 8 prognostic prognostic JJ cord-015365-iqdi99pd 305 9 factor factor NN cord-015365-iqdi99pd 305 10 for for IN cord-015365-iqdi99pd 305 11 kidney kidney NN cord-015365-iqdi99pd 305 12 function function NN cord-015365-iqdi99pd 305 13 early early RB cord-015365-iqdi99pd 305 14 after after IN cord-015365-iqdi99pd 305 15 transplantation transplantation NN cord-015365-iqdi99pd 305 16 . . . cord-015365-iqdi99pd 306 1 A a DT cord-015365-iqdi99pd 306 2 detailed detailed JJ cord-015365-iqdi99pd 306 3 analysis analysis NN cord-015365-iqdi99pd 306 4 of of IN cord-015365-iqdi99pd 306 5 phenotype phenotype NN cord-015365-iqdi99pd 306 6 and and CC cord-015365-iqdi99pd 306 7 function function NN cord-015365-iqdi99pd 306 8 of of IN cord-015365-iqdi99pd 306 9 lymphocytes lymphocyte NNS cord-015365-iqdi99pd 306 10 after after IN cord-015365-iqdi99pd 306 11 alemtuzumab alemtuzumab NNP cord-015365-iqdi99pd 306 12 induction induction NN cord-015365-iqdi99pd 306 13 together together RB cord-015365-iqdi99pd 306 14 with with IN cord-015365-iqdi99pd 306 15 a a DT cord-015365-iqdi99pd 306 16 correlation correlation NN cord-015365-iqdi99pd 306 17 with with IN cord-015365-iqdi99pd 306 18 the the DT cord-015365-iqdi99pd 306 19 clinical clinical JJ cord-015365-iqdi99pd 306 20 course course NN cord-015365-iqdi99pd 306 21 is be VBZ cord-015365-iqdi99pd 306 22 warranted warrant VBN cord-015365-iqdi99pd 306 23 . . . cord-015365-iqdi99pd 307 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 307 2 - - HYPH cord-015365-iqdi99pd 307 3 based base VBN cord-015365-iqdi99pd 307 4 immunosuppression immunosuppression NN cord-015365-iqdi99pd 307 5 in in IN cord-015365-iqdi99pd 307 6 de de NNP cord-015365-iqdi99pd 307 7 novo novo NNP cord-015365-iqdi99pd 307 8 liver liver NN cord-015365-iqdi99pd 307 9 transplant transplant NN cord-015365-iqdi99pd 307 10 recipients recipient NNS cord-015365-iqdi99pd 307 11 : : : cord-015365-iqdi99pd 307 12 1-year 1-year CD cord-015365-iqdi99pd 307 13 experience experience NN cord-015365-iqdi99pd 307 14 from from IN cord-015365-iqdi99pd 307 15 a a DT cord-015365-iqdi99pd 307 16 phase phase NN cord-015365-iqdi99pd 307 17 II ii CD cord-015365-iqdi99pd 307 18 study study NN cord-015365-iqdi99pd 307 19 Background Background NNP cord-015365-iqdi99pd 307 20 . . . cord-015365-iqdi99pd 308 1 Calcineurin Calcineurin NNP cord-015365-iqdi99pd 308 2 inhibitors inhibitor NNS cord-015365-iqdi99pd 308 3 contribute contribute VBP cord-015365-iqdi99pd 308 4 to to IN cord-015365-iqdi99pd 308 5 substantial substantial JJ cord-015365-iqdi99pd 308 6 toxicities toxicity NNS cord-015365-iqdi99pd 308 7 in in IN cord-015365-iqdi99pd 308 8 liver liver NN cord-015365-iqdi99pd 308 9 transplant transplant NN cord-015365-iqdi99pd 308 10 ( ( -LRB- cord-015365-iqdi99pd 308 11 LT LT NNP cord-015365-iqdi99pd 308 12 ) ) -RRB- cord-015365-iqdi99pd 308 13 patients patient NNS cord-015365-iqdi99pd 308 14 that that WDT cord-015365-iqdi99pd 308 15 can can MD cord-015365-iqdi99pd 308 16 lead lead VB cord-015365-iqdi99pd 308 17 to to IN cord-015365-iqdi99pd 308 18 renal renal JJ cord-015365-iqdi99pd 308 19 dysfunction dysfunction NN cord-015365-iqdi99pd 308 20 / / SYM cord-015365-iqdi99pd 308 21 failure failure NN cord-015365-iqdi99pd 308 22 and and CC cord-015365-iqdi99pd 308 23 cardiovascular cardiovascular JJ cord-015365-iqdi99pd 308 24 ( ( -LRB- cord-015365-iqdi99pd 308 25 CV cv NN cord-015365-iqdi99pd 308 26 ) ) -RRB- cord-015365-iqdi99pd 308 27 disease disease NN cord-015365-iqdi99pd 308 28 . . . cord-015365-iqdi99pd 309 1 This this DT cord-015365-iqdi99pd 309 2 phase phase NN cord-015365-iqdi99pd 309 3 II ii CD cord-015365-iqdi99pd 309 4 study study NN cord-015365-iqdi99pd 309 5 evaluated evaluate VBD cord-015365-iqdi99pd 309 6 belatacept belatacept NN cord-015365-iqdi99pd 309 7 versus versus IN cord-015365-iqdi99pd 309 8 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 309 9 ( ( -LRB- cord-015365-iqdi99pd 309 10 Tac Tac NNP cord-015365-iqdi99pd 309 11 ) ) -RRB- cord-015365-iqdi99pd 309 12 in in IN cord-015365-iqdi99pd 309 13 de de NNP cord-015365-iqdi99pd 309 14 novo novo NNP cord-015365-iqdi99pd 309 15 LT LT NNP cord-015365-iqdi99pd 309 16 recipients recipient NNS cord-015365-iqdi99pd 309 17 . . . cord-015365-iqdi99pd 310 1 Methods method NNS cord-015365-iqdi99pd 310 2 . . . cord-015365-iqdi99pd 311 1 250 250 CD cord-015365-iqdi99pd 311 2 LT LT NNP cord-015365-iqdi99pd 311 3 recipients recipient NNS cord-015365-iqdi99pd 311 4 were be VBD cord-015365-iqdi99pd 311 5 randomized randomize VBN cord-015365-iqdi99pd 311 6 to to IN cord-015365-iqdi99pd 311 7 belataceptbased belataceptbased JJ cord-015365-iqdi99pd 311 8 ( ( -LRB- cord-015365-iqdi99pd 311 9 high high JJ cord-015365-iqdi99pd 311 10 dose dose NN cord-015365-iqdi99pd 311 11 [ [ -LRB- cord-015365-iqdi99pd 311 12 HD hd NN cord-015365-iqdi99pd 311 13 ] ] -RRB- cord-015365-iqdi99pd 311 14 or or CC cord-015365-iqdi99pd 311 15 low low JJ cord-015365-iqdi99pd 311 16 dose dose NN cord-015365-iqdi99pd 311 17 [ [ -LRB- cord-015365-iqdi99pd 311 18 LD LD NNP cord-015365-iqdi99pd 311 19 ] ] -RRB- cord-015365-iqdi99pd 311 20 ) ) -RRB- cord-015365-iqdi99pd 311 21 or or CC cord-015365-iqdi99pd 311 22 Tac Tac NNP cord-015365-iqdi99pd 311 23 - - HYPH cord-015365-iqdi99pd 311 24 based base VBN cord-015365-iqdi99pd 311 25 regimens regimen NNS cord-015365-iqdi99pd 311 26 . . . cord-015365-iqdi99pd 312 1 All all DT cord-015365-iqdi99pd 312 2 patients patient NNS cord-015365-iqdi99pd 312 3 received receive VBD cord-015365-iqdi99pd 312 4 steroids steroid NNS cord-015365-iqdi99pd 312 5 for for IN cord-015365-iqdi99pd 312 6 the the DT cord-015365-iqdi99pd 312 7 first first JJ cord-015365-iqdi99pd 312 8 3 3 CD cord-015365-iqdi99pd 312 9 months month NNS cord-015365-iqdi99pd 312 10 . . . cord-015365-iqdi99pd 313 1 Results result NNS cord-015365-iqdi99pd 313 2 . . . cord-015365-iqdi99pd 314 1 Demographic demographic JJ cord-015365-iqdi99pd 314 2 characteristics characteristic NNS cord-015365-iqdi99pd 314 3 were be VBD cord-015365-iqdi99pd 314 4 similar similar JJ cord-015365-iqdi99pd 314 5 among among IN cord-015365-iqdi99pd 314 6 groups group NNS cord-015365-iqdi99pd 314 7 ; ; : cord-015365-iqdi99pd 314 8 46 46 CD cord-015365-iqdi99pd 314 9 % % NN cord-015365-iqdi99pd 314 10 of of IN cord-015365-iqdi99pd 314 11 patients patient NNS cord-015365-iqdi99pd 314 12 were be VBD cord-015365-iqdi99pd 314 13 HCV HCV NNP cord-015365-iqdi99pd 314 14 positive positive JJ cord-015365-iqdi99pd 314 15 . . . cord-015365-iqdi99pd 315 1 The the DT cord-015365-iqdi99pd 315 2 primary primary JJ cord-015365-iqdi99pd 315 3 endpoint endpoint NN cord-015365-iqdi99pd 315 4 ( ( -LRB- cord-015365-iqdi99pd 315 5 composite composite NN cord-015365-iqdi99pd 315 6 of of IN cord-015365-iqdi99pd 315 7 acute acute JJ cord-015365-iqdi99pd 315 8 rejection rejection NN cord-015365-iqdi99pd 315 9 [ [ -LRB- cord-015365-iqdi99pd 315 10 AR AR NNP cord-015365-iqdi99pd 315 11 ] ] -RRB- cord-015365-iqdi99pd 315 12 , , , cord-015365-iqdi99pd 315 13 graft graft NN cord-015365-iqdi99pd 315 14 loss loss NN cord-015365-iqdi99pd 315 15 [ [ -LRB- cord-015365-iqdi99pd 315 16 GL GL NNP cord-015365-iqdi99pd 315 17 ] ] -RRB- cord-015365-iqdi99pd 315 18 , , , cord-015365-iqdi99pd 315 19 and and CC cord-015365-iqdi99pd 315 20 death death NN cord-015365-iqdi99pd 315 21 by by IN cord-015365-iqdi99pd 315 22 month month NN cord-015365-iqdi99pd 315 23 6 6 CD cord-015365-iqdi99pd 315 24 ) ) -RRB- cord-015365-iqdi99pd 315 25 occurred occur VBD cord-015365-iqdi99pd 315 26 more more RBR cord-015365-iqdi99pd 315 27 frequently frequently RB cord-015365-iqdi99pd 315 28 in in IN cord-015365-iqdi99pd 315 29 belatacept belatacept NN cord-015365-iqdi99pd 315 30 groups group NNS cord-015365-iqdi99pd 315 31 . . . cord-015365-iqdi99pd 316 1 By by IN cord-015365-iqdi99pd 316 2 year year NN cord-015365-iqdi99pd 316 3 1 1 CD cord-015365-iqdi99pd 316 4 , , , cord-015365-iqdi99pd 316 5 more more JJR cord-015365-iqdi99pd 316 6 deaths death NNS cord-015365-iqdi99pd 316 7 and and CC cord-015365-iqdi99pd 316 8 GL GL NNP cord-015365-iqdi99pd 316 9 occurred occur VBD cord-015365-iqdi99pd 316 10 with with IN cord-015365-iqdi99pd 316 11 belatacept belatacept NN cord-015365-iqdi99pd 316 12 LD LD NNP cord-015365-iqdi99pd 316 13 vs. vs. IN cord-015365-iqdi99pd 316 14 other other JJ cord-015365-iqdi99pd 316 15 groups group NNS cord-015365-iqdi99pd 316 16 . . . cord-015365-iqdi99pd 317 1 Causes cause NNS cord-015365-iqdi99pd 317 2 of of IN cord-015365-iqdi99pd 317 3 early early JJ cord-015365-iqdi99pd 317 4 ( ( -LRB- cord-015365-iqdi99pd 317 5 by by IN cord-015365-iqdi99pd 317 6 6 6 CD cord-015365-iqdi99pd 317 7 weeks week NNS cord-015365-iqdi99pd 317 8 ) ) -RRB- cord-015365-iqdi99pd 318 1 death death NN cord-015365-iqdi99pd 318 2 and and CC cord-015365-iqdi99pd 318 3 GL GL NNP cord-015365-iqdi99pd 318 4 were be VBD cord-015365-iqdi99pd 318 5 mostly mostly RB cord-015365-iqdi99pd 318 6 due due JJ cord-015365-iqdi99pd 318 7 to to IN cord-015365-iqdi99pd 318 8 postoperative postoperative JJ cord-015365-iqdi99pd 318 9 complications complication NNS cord-015365-iqdi99pd 318 10 ; ; . cord-015365-iqdi99pd 319 1 thereafter thereafter RB cord-015365-iqdi99pd 319 2 causes cause NNS cord-015365-iqdi99pd 319 3 included include VBD cord-015365-iqdi99pd 319 4 sepsis sepsis NN cord-015365-iqdi99pd 319 5 , , , cord-015365-iqdi99pd 319 6 PTLD PTLD NNP cord-015365-iqdi99pd 319 7 , , , cord-015365-iqdi99pd 319 8 and and CC cord-015365-iqdi99pd 319 9 multi multi JJ cord-015365-iqdi99pd 319 10 - - JJ cord-015365-iqdi99pd 319 11 organ organ JJ cord-015365-iqdi99pd 319 12 failure failure NN cord-015365-iqdi99pd 319 13 . . . cord-015365-iqdi99pd 320 1 AR AR NNP cord-015365-iqdi99pd 320 2 was be VBD cord-015365-iqdi99pd 320 3 more more RBR cord-015365-iqdi99pd 320 4 common common JJ cord-015365-iqdi99pd 320 5 with with IN cord-015365-iqdi99pd 320 6 belatacept belatacept NN cord-015365-iqdi99pd 320 7 - - HYPH cord-015365-iqdi99pd 320 8 based base VBN cord-015365-iqdi99pd 320 9 regimens regimen NNS cord-015365-iqdi99pd 320 10 compared compare VBN cord-015365-iqdi99pd 320 11 to to IN cord-015365-iqdi99pd 320 12 Tac Tac NNP cord-015365-iqdi99pd 320 13 þ þ NNP cord-015365-iqdi99pd 320 14 MMF mmf NN cord-015365-iqdi99pd 320 15 . . . cord-015365-iqdi99pd 321 1 By by IN cord-015365-iqdi99pd 321 2 1 1 CD cord-015365-iqdi99pd 321 3 year year NN cord-015365-iqdi99pd 321 4 , , , cord-015365-iqdi99pd 321 5 mean mean JJ cord-015365-iqdi99pd 321 6 cGFR cGFR NNP cord-015365-iqdi99pd 321 7 was be VBD cord-015365-iqdi99pd 321 8 15 15 CD cord-015365-iqdi99pd 321 9 - - SYM cord-015365-iqdi99pd 321 10 34 34 CD cord-015365-iqdi99pd 321 11 mL ml NN cord-015365-iqdi99pd 321 12 / / SYM cord-015365-iqdi99pd 321 13 min min NN cord-015365-iqdi99pd 321 14 higher higher RBR cord-015365-iqdi99pd 321 15 in in IN cord-015365-iqdi99pd 321 16 belatacept belatacept NN cord-015365-iqdi99pd 321 17 vs. vs. FW cord-015365-iqdi99pd 321 18 Tac Tac NNP cord-015365-iqdi99pd 321 19 groups group NNS cord-015365-iqdi99pd 321 20 . . . cord-015365-iqdi99pd 322 1 Lower low JJR cord-015365-iqdi99pd 322 2 blood blood NN cord-015365-iqdi99pd 322 3 pressure pressure NN cord-015365-iqdi99pd 322 4 and and CC cord-015365-iqdi99pd 322 5 less less JJR cord-015365-iqdi99pd 322 6 neurotoxicity neurotoxicity NN cord-015365-iqdi99pd 322 7 were be VBD cord-015365-iqdi99pd 322 8 observed observe VBN cord-015365-iqdi99pd 322 9 with with IN cord-015365-iqdi99pd 322 10 belatacept belatacept NN cord-015365-iqdi99pd 322 11 treatment treatment NN cord-015365-iqdi99pd 322 12 . . . cord-015365-iqdi99pd 323 1 2 2 LS cord-015365-iqdi99pd 323 2 PTLD PTLD NNP cord-015365-iqdi99pd 323 3 cases case NNS cord-015365-iqdi99pd 323 4 and and CC cord-015365-iqdi99pd 323 5 1 1 CD cord-015365-iqdi99pd 323 6 PML PML NNP cord-015365-iqdi99pd 323 7 case case NN cord-015365-iqdi99pd 323 8 ( ( -LRB- cord-015365-iqdi99pd 323 9 HD HD NNP cord-015365-iqdi99pd 323 10 group group NN cord-015365-iqdi99pd 323 11 ) ) -RRB- cord-015365-iqdi99pd 323 12 occurred occur VBD cord-015365-iqdi99pd 323 13 in in IN cord-015365-iqdi99pd 323 14 the the DT cord-015365-iqdi99pd 323 15 belatacept belatacept NN cord-015365-iqdi99pd 323 16 groups group NNS cord-015365-iqdi99pd 323 17 . . . cord-015365-iqdi99pd 324 1 Conclusions conclusion NNS cord-015365-iqdi99pd 324 2 . . . cord-015365-iqdi99pd 325 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 325 2 HD HD NNP cord-015365-iqdi99pd 325 3 group group NN cord-015365-iqdi99pd 325 4 had have VBD cord-015365-iqdi99pd 325 5 comparable comparable JJ cord-015365-iqdi99pd 325 6 efficacy efficacy NN cord-015365-iqdi99pd 325 7 relative relative JJ cord-015365-iqdi99pd 325 8 to to IN cord-015365-iqdi99pd 325 9 Tac Tac NNP cord-015365-iqdi99pd 325 10 alone alone RB cord-015365-iqdi99pd 325 11 but but CC cord-015365-iqdi99pd 325 12 was be VBD cord-015365-iqdi99pd 325 13 less less RBR cord-015365-iqdi99pd 325 14 effective effective JJ cord-015365-iqdi99pd 325 15 compared compare VBN cord-015365-iqdi99pd 325 16 to to IN cord-015365-iqdi99pd 325 17 Tac Tac NNP cord-015365-iqdi99pd 325 18 þ þ NNP cord-015365-iqdi99pd 325 19 MMF mmf NN cord-015365-iqdi99pd 325 20 . . . cord-015365-iqdi99pd 326 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 326 2 LD LD NNP cord-015365-iqdi99pd 326 3 group group NN cord-015365-iqdi99pd 326 4 was be VBD cord-015365-iqdi99pd 326 5 less less RBR cord-015365-iqdi99pd 326 6 effective effective JJ cord-015365-iqdi99pd 326 7 with with IN cord-015365-iqdi99pd 326 8 more more JJR cord-015365-iqdi99pd 326 9 deaths death NNS cord-015365-iqdi99pd 326 10 and and CC cord-015365-iqdi99pd 326 11 GL GL NNP cord-015365-iqdi99pd 326 12 observed observe VBD cord-015365-iqdi99pd 326 13 compared compare VBD cord-015365-iqdi99pd 326 14 to to IN cord-015365-iqdi99pd 326 15 both both CC cord-015365-iqdi99pd 326 16 Tac Tac NNP cord-015365-iqdi99pd 326 17 - - HYPH cord-015365-iqdi99pd 326 18 based base VBN cord-015365-iqdi99pd 326 19 groups group NNS cord-015365-iqdi99pd 326 20 . . . cord-015365-iqdi99pd 327 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 327 2 provided provide VBD cord-015365-iqdi99pd 327 3 improved improved JJ cord-015365-iqdi99pd 327 4 renal renal JJ cord-015365-iqdi99pd 327 5 function function NN cord-015365-iqdi99pd 327 6 with with IN cord-015365-iqdi99pd 327 7 less less JJR cord-015365-iqdi99pd 327 8 CV cv NN cord-015365-iqdi99pd 327 9 / / SYM cord-015365-iqdi99pd 327 10 metabolic metabolic JJ cord-015365-iqdi99pd 327 11 and and CC cord-015365-iqdi99pd 327 12 neurotoxicities neurotoxicitie NNS cord-015365-iqdi99pd 327 13 vs. vs. IN cord-015365-iqdi99pd 327 14 Tac Tac NNP cord-015365-iqdi99pd 327 15 - - HYPH cord-015365-iqdi99pd 327 16 based base VBN cord-015365-iqdi99pd 327 17 regimens regimen NNS cord-015365-iqdi99pd 327 18 . . . cord-015365-iqdi99pd 328 1 PTLD PTLD NNP cord-015365-iqdi99pd 328 2 and and CC cord-015365-iqdi99pd 328 3 PML PML NNP cord-015365-iqdi99pd 328 4 were be VBD cord-015365-iqdi99pd 328 5 observed observe VBN cord-015365-iqdi99pd 328 6 with with IN cord-015365-iqdi99pd 328 7 belatacept belatacept NN cord-015365-iqdi99pd 328 8 . . . cord-015365-iqdi99pd 329 1 The the DT cord-015365-iqdi99pd 329 2 optimal optimal JJ cord-015365-iqdi99pd 329 3 dose dose NN cord-015365-iqdi99pd 329 4 / / SYM cord-015365-iqdi99pd 329 5 regimen regimen NN cord-015365-iqdi99pd 329 6 of of IN cord-015365-iqdi99pd 329 7 belatacept belatacept NN cord-015365-iqdi99pd 329 8 in in IN cord-015365-iqdi99pd 329 9 LT LT NNP cord-015365-iqdi99pd 329 10 is be VBZ cord-015365-iqdi99pd 329 11 yet yet RB cord-015365-iqdi99pd 329 12 to to TO cord-015365-iqdi99pd 329 13 be be VB cord-015365-iqdi99pd 329 14 determined determine VBN cord-015365-iqdi99pd 329 15 . . . cord-015365-iqdi99pd 330 1 CMV CMV NNP cord-015365-iqdi99pd 330 2 late late JJ cord-015365-iqdi99pd 330 3 phase phase NN cord-015365-iqdi99pd 330 4 - - HYPH cord-015365-iqdi99pd 330 5 induced induce VBN cord-015365-iqdi99pd 330 6 mTOR mTOR NNP cord-015365-iqdi99pd 330 7 activation activation NN cord-015365-iqdi99pd 330 8 is be VBZ cord-015365-iqdi99pd 330 9 essential essential JJ cord-015365-iqdi99pd 330 10 for for IN cord-015365-iqdi99pd 330 11 efficient efficient JJ cord-015365-iqdi99pd 330 12 virus virus NN cord-015365-iqdi99pd 330 13 replication replication NN cord-015365-iqdi99pd 330 14 in in IN cord-015365-iqdi99pd 330 15 human human JJ cord-015365-iqdi99pd 330 16 M2-polarized m2-polarize VBN cord-015365-iqdi99pd 330 17 macrophages macrophage NNS cord-015365-iqdi99pd 330 18 Human Human NNP cord-015365-iqdi99pd 330 19 Cytomegalovirus Cytomegalovirus NNP cord-015365-iqdi99pd 330 20 ( ( -LRB- cord-015365-iqdi99pd 330 21 CMV CMV NNP cord-015365-iqdi99pd 330 22 ) ) -RRB- cord-015365-iqdi99pd 330 23 remains remain VBZ cord-015365-iqdi99pd 330 24 one one CD cord-015365-iqdi99pd 330 25 of of IN cord-015365-iqdi99pd 330 26 the the DT cord-015365-iqdi99pd 330 27 most most RBS cord-015365-iqdi99pd 330 28 important important JJ cord-015365-iqdi99pd 330 29 pathogens pathogen NNS cord-015365-iqdi99pd 330 30 following follow VBG cord-015365-iqdi99pd 330 31 solid solid JJ cord-015365-iqdi99pd 330 32 - - HYPH cord-015365-iqdi99pd 330 33 organ organ NN cord-015365-iqdi99pd 330 34 transplantation transplantation NN cord-015365-iqdi99pd 330 35 , , , cord-015365-iqdi99pd 330 36 potentially potentially RB cord-015365-iqdi99pd 330 37 leading lead VBG cord-015365-iqdi99pd 330 38 to to IN cord-015365-iqdi99pd 330 39 CMV CMV NNP cord-015365-iqdi99pd 330 40 disease disease NN cord-015365-iqdi99pd 330 41 , , , cord-015365-iqdi99pd 330 42 allograft allograft NN cord-015365-iqdi99pd 330 43 dysfunction dysfunction NN cord-015365-iqdi99pd 330 44 , , , cord-015365-iqdi99pd 330 45 acute acute JJ cord-015365-iqdi99pd 330 46 and and CC cord-015365-iqdi99pd 330 47 chronic chronic JJ cord-015365-iqdi99pd 330 48 rejection rejection NN cord-015365-iqdi99pd 330 49 and and CC cord-015365-iqdi99pd 330 50 opportunistic opportunistic JJ cord-015365-iqdi99pd 330 51 infections infection NNS cord-015365-iqdi99pd 330 52 . . . cord-015365-iqdi99pd 331 1 Mounting mount VBG cord-015365-iqdi99pd 331 2 evidence evidence NN cord-015365-iqdi99pd 331 3 indicates indicate VBZ cord-015365-iqdi99pd 331 4 that that IN cord-015365-iqdi99pd 331 5 mammalian mammalian JJ cord-015365-iqdi99pd 331 6 target target NN cord-015365-iqdi99pd 331 7 of of IN cord-015365-iqdi99pd 331 8 rapamycin rapamycin NNP cord-015365-iqdi99pd 331 9 ( ( -LRB- cord-015365-iqdi99pd 331 10 mTOR mTOR NNP cord-015365-iqdi99pd 331 11 ) ) -RRB- cord-015365-iqdi99pd 331 12 inhibitors inhibitor NNS cord-015365-iqdi99pd 331 13 may may MD cord-015365-iqdi99pd 331 14 decrease decrease VB cord-015365-iqdi99pd 331 15 the the DT cord-015365-iqdi99pd 331 16 incidence incidence NN cord-015365-iqdi99pd 331 17 of of IN cord-015365-iqdi99pd 331 18 CMV CMV NNP cord-015365-iqdi99pd 331 19 infection infection NN cord-015365-iqdi99pd 331 20 in in IN cord-015365-iqdi99pd 331 21 renal renal JJ cord-015365-iqdi99pd 331 22 transplant transplant NN cord-015365-iqdi99pd 331 23 recipients recipient NNS cord-015365-iqdi99pd 331 24 . . . cord-015365-iqdi99pd 332 1 Here here RB cord-015365-iqdi99pd 332 2 we -PRON- PRP cord-015365-iqdi99pd 332 3 aimed aim VBD cord-015365-iqdi99pd 332 4 to to TO cord-015365-iqdi99pd 332 5 elucidate elucidate VB cord-015365-iqdi99pd 332 6 the the DT cord-015365-iqdi99pd 332 7 molecular molecular JJ cord-015365-iqdi99pd 332 8 mechanisms mechanism NNS cord-015365-iqdi99pd 332 9 of of IN cord-015365-iqdi99pd 332 10 this this DT cord-015365-iqdi99pd 332 11 effect effect NN cord-015365-iqdi99pd 332 12 by by IN cord-015365-iqdi99pd 332 13 employing employ VBG cord-015365-iqdi99pd 332 14 a a DT cord-015365-iqdi99pd 332 15 human human JJ cord-015365-iqdi99pd 332 16 CMV CMV NNP cord-015365-iqdi99pd 332 17 ( ( -LRB- cord-015365-iqdi99pd 332 18 HCMV HCMV NNP cord-015365-iqdi99pd 332 19 ) ) -RRB- cord-015365-iqdi99pd 332 20 infection infection NN cord-015365-iqdi99pd 332 21 model model NN cord-015365-iqdi99pd 332 22 in in IN cord-015365-iqdi99pd 332 23 human human JJ cord-015365-iqdi99pd 332 24 macrophages macrophage NNS cord-015365-iqdi99pd 332 25 , , , cord-015365-iqdi99pd 332 26 since since IN cord-015365-iqdi99pd 332 27 myeloid myeloid JJ cord-015365-iqdi99pd 332 28 cells cell NNS cord-015365-iqdi99pd 332 29 are be VBP cord-015365-iqdi99pd 332 30 the the DT cord-015365-iqdi99pd 332 31 principal principal NN cord-015365-iqdi99pd 332 32 in in IN cord-015365-iqdi99pd 332 33 vivo vivo NN cord-015365-iqdi99pd 332 34 targets target NNS cord-015365-iqdi99pd 332 35 of of IN cord-015365-iqdi99pd 332 36 HCMV HCMV NNP cord-015365-iqdi99pd 332 37 and and CC cord-015365-iqdi99pd 332 38 the the DT cord-015365-iqdi99pd 332 39 major major JJ cord-015365-iqdi99pd 332 40 viral viral JJ cord-015365-iqdi99pd 332 41 source source NN cord-015365-iqdi99pd 332 42 during during IN cord-015365-iqdi99pd 332 43 early early JJ cord-015365-iqdi99pd 332 44 CMV CMV NNP cord-015365-iqdi99pd 332 45 disease disease NN cord-015365-iqdi99pd 332 46 . . . cord-015365-iqdi99pd 333 1 Here here RB cord-015365-iqdi99pd 333 2 we -PRON- PRP cord-015365-iqdi99pd 333 3 demonstrate demonstrate VBP cord-015365-iqdi99pd 333 4 that that DT cord-015365-iqdi99pd 333 5 polarization polarization NN cord-015365-iqdi99pd 333 6 of of IN cord-015365-iqdi99pd 333 7 macrophages macrophage NNS cord-015365-iqdi99pd 333 8 into into IN cord-015365-iqdi99pd 333 9 M1 M1 NNP cord-015365-iqdi99pd 333 10 and and CC cord-015365-iqdi99pd 333 11 M2 M2 NNP cord-015365-iqdi99pd 333 12 macrophages macrophage NNS cord-015365-iqdi99pd 333 13 resulted result VBD cord-015365-iqdi99pd 333 14 in in IN cord-015365-iqdi99pd 333 15 highly highly RB cord-015365-iqdi99pd 333 16 divergent divergent JJ cord-015365-iqdi99pd 333 17 host host NN cord-015365-iqdi99pd 333 18 cell cell NN cord-015365-iqdi99pd 333 19 permissiveness permissiveness NN cord-015365-iqdi99pd 333 20 for for IN cord-015365-iqdi99pd 333 21 HCMV HCMV NNP cord-015365-iqdi99pd 333 22 with with IN cord-015365-iqdi99pd 333 23 optimal optimal JJ cord-015365-iqdi99pd 333 24 infection infection NN cord-015365-iqdi99pd 333 25 susceptibility susceptibility NN cord-015365-iqdi99pd 333 26 in in IN cord-015365-iqdi99pd 333 27 M2 M2 NNP cord-015365-iqdi99pd 333 28 versus versus IN cord-015365-iqdi99pd 333 29 M1 M1 NNP cord-015365-iqdi99pd 333 30 macrophages macrophage NNS cord-015365-iqdi99pd 333 31 . . . cord-015365-iqdi99pd 334 1 Employing employ VBG cord-015365-iqdi99pd 334 2 an an DT cord-015365-iqdi99pd 334 3 ultra ultra JJ cord-015365-iqdi99pd 334 4 - - JJ cord-015365-iqdi99pd 334 5 high high JJ cord-015365-iqdi99pd 334 6 purified purify VBN cord-015365-iqdi99pd 334 7 HCMV HCMV NNP cord-015365-iqdi99pd 334 8 stock stock NN cord-015365-iqdi99pd 334 9 ( ( -LRB- cord-015365-iqdi99pd 334 10 TB-40 TB-40 NNP cord-015365-iqdi99pd 334 11 / / SYM cord-015365-iqdi99pd 334 12 E e NN cord-015365-iqdi99pd 334 13 ) ) -RRB- cord-015365-iqdi99pd 334 14 selective selective JJ cord-015365-iqdi99pd 334 15 rapamycinindependent rapamycinindependent JJ cord-015365-iqdi99pd 334 16 induction induction NN cord-015365-iqdi99pd 334 17 of of IN cord-015365-iqdi99pd 334 18 IFN IFN NNP cord-015365-iqdi99pd 334 19 - - HYPH cord-015365-iqdi99pd 334 20 transcripts transcript NNS cord-015365-iqdi99pd 334 21 , , , cord-015365-iqdi99pd 334 22 but but CC cord-015365-iqdi99pd 334 23 no no DT cord-015365-iqdi99pd 334 24 proinflammatory proinflammatory JJ cord-015365-iqdi99pd 334 25 cytokines cytokine NNS cord-015365-iqdi99pd 334 26 or or CC cord-015365-iqdi99pd 334 27 early early JJ cord-015365-iqdi99pd 334 28 signalling signal VBG cord-015365-iqdi99pd 334 29 events event NNS cord-015365-iqdi99pd 334 30 including include VBG cord-015365-iqdi99pd 334 31 MAPK MAPK NNP cord-015365-iqdi99pd 334 32 and and CC cord-015365-iqdi99pd 334 33 mTOR mTOR NNP cord-015365-iqdi99pd 334 34 signalling signalling NN cord-015365-iqdi99pd 334 35 could could MD cord-015365-iqdi99pd 334 36 be be VB cord-015365-iqdi99pd 334 37 detected detect VBN cord-015365-iqdi99pd 334 38 . . . cord-015365-iqdi99pd 335 1 Assessment assessment NN cord-015365-iqdi99pd 335 2 of of IN cord-015365-iqdi99pd 335 3 viral viral JJ cord-015365-iqdi99pd 335 4 gene gene NN cord-015365-iqdi99pd 335 5 expression expression NN cord-015365-iqdi99pd 335 6 and and CC cord-015365-iqdi99pd 335 7 mTORC1 mtorc1 CD cord-015365-iqdi99pd 335 8 activity activity NN cord-015365-iqdi99pd 335 9 during during IN cord-015365-iqdi99pd 335 10 the the DT cord-015365-iqdi99pd 335 11 course course NN cord-015365-iqdi99pd 335 12 of of IN cord-015365-iqdi99pd 335 13 macrophage macrophage NN cord-015365-iqdi99pd 335 14 infection infection NN cord-015365-iqdi99pd 335 15 revealed reveal VBD cord-015365-iqdi99pd 335 16 that that IN cord-015365-iqdi99pd 335 17 rapamycin rapamycin NNS cord-015365-iqdi99pd 335 18 significantly significantly RB cord-015365-iqdi99pd 335 19 suppressed suppress VBD cord-015365-iqdi99pd 335 20 CMV CMV NNP cord-015365-iqdi99pd 335 21 replication replication NN cord-015365-iqdi99pd 335 22 3 3 CD cord-015365-iqdi99pd 335 23 and and CC cord-015365-iqdi99pd 335 24 5 5 CD cord-015365-iqdi99pd 335 25 days day NNS cord-015365-iqdi99pd 335 26 post post NN cord-015365-iqdi99pd 335 27 infection infection NN cord-015365-iqdi99pd 335 28 , , , cord-015365-iqdi99pd 335 29 while while IN cord-015365-iqdi99pd 335 30 CMV CMV NNP cord-015365-iqdi99pd 335 31 proliferation proliferation NN cord-015365-iqdi99pd 335 32 in in IN cord-015365-iqdi99pd 335 33 fibroblasts fibroblast NNS cord-015365-iqdi99pd 335 34 was be VBD cord-015365-iqdi99pd 335 35 largely largely RB cord-015365-iqdi99pd 335 36 unaffected unaffected JJ cord-015365-iqdi99pd 335 37 by by IN cord-015365-iqdi99pd 335 38 mTOR mtor NN cord-015365-iqdi99pd 335 39 - - HYPH cord-015365-iqdi99pd 335 40 blockade blockade NN cord-015365-iqdi99pd 335 41 . . . cord-015365-iqdi99pd 336 1 Analysis analysis NN cord-015365-iqdi99pd 336 2 of of IN cord-015365-iqdi99pd 336 3 mTORC1 mTORC1 NNP cord-015365-iqdi99pd 336 4 activation activation NN cord-015365-iqdi99pd 336 5 and and CC cord-015365-iqdi99pd 336 6 late late JJ cord-015365-iqdi99pd 336 7 phase phase NN cord-015365-iqdi99pd 336 8 viral viral JJ cord-015365-iqdi99pd 336 9 proteins protein NNS cord-015365-iqdi99pd 336 10 including include VBG cord-015365-iqdi99pd 336 11 pUL-44 pul-44 NN cord-015365-iqdi99pd 336 12 and and CC cord-015365-iqdi99pd 336 13 pp65 pp65 RB cord-015365-iqdi99pd 336 14 signified signify VBD cord-015365-iqdi99pd 336 15 an an DT cord-015365-iqdi99pd 336 16 exquisite exquisite JJ cord-015365-iqdi99pd 336 17 mTORC1 mtorc1 JJ cord-015365-iqdi99pd 336 18 dependency dependency NN cord-015365-iqdi99pd 336 19 of of IN cord-015365-iqdi99pd 336 20 protein protein NN cord-015365-iqdi99pd 336 21 synthesis synthesis NN cord-015365-iqdi99pd 336 22 during during IN cord-015365-iqdi99pd 336 23 the the DT cord-015365-iqdi99pd 336 24 late late JJ cord-015365-iqdi99pd 336 25 phases phase NNS cord-015365-iqdi99pd 336 26 of of IN cord-015365-iqdi99pd 336 27 viral viral JJ cord-015365-iqdi99pd 336 28 replication replication NN cord-015365-iqdi99pd 336 29 . . . cord-015365-iqdi99pd 337 1 Collectively collectively RB cord-015365-iqdi99pd 337 2 , , , cord-015365-iqdi99pd 337 3 these these DT cord-015365-iqdi99pd 337 4 data datum NNS cord-015365-iqdi99pd 337 5 indicate indicate VBP cord-015365-iqdi99pd 337 6 that that IN cord-015365-iqdi99pd 337 7 mTORC1 mTORC1 NNP cord-015365-iqdi99pd 337 8 is be VBZ cord-015365-iqdi99pd 337 9 essential essential JJ cord-015365-iqdi99pd 337 10 for for IN cord-015365-iqdi99pd 337 11 virus virus NN cord-015365-iqdi99pd 337 12 replication replication NN cord-015365-iqdi99pd 337 13 during during IN cord-015365-iqdi99pd 337 14 late late JJ cord-015365-iqdi99pd 337 15 phases phase NNS cord-015365-iqdi99pd 337 16 of of IN cord-015365-iqdi99pd 337 17 the the DT cord-015365-iqdi99pd 337 18 viral viral JJ cord-015365-iqdi99pd 337 19 cycle cycle NN cord-015365-iqdi99pd 337 20 in in IN cord-015365-iqdi99pd 337 21 myeloid myeloid JJ cord-015365-iqdi99pd 337 22 cells cell NNS cord-015365-iqdi99pd 337 23 which which WDT cord-015365-iqdi99pd 337 24 might may MD cord-015365-iqdi99pd 337 25 explain explain VB cord-015365-iqdi99pd 337 26 the the DT cord-015365-iqdi99pd 337 27 potent potent JJ cord-015365-iqdi99pd 337 28 anti anti JJ cord-015365-iqdi99pd 337 29 - - JJ cord-015365-iqdi99pd 337 30 CMV cmv JJ cord-015365-iqdi99pd 337 31 effects effect NNS cord-015365-iqdi99pd 337 32 of of IN cord-015365-iqdi99pd 337 33 mTOR mTOR NNP cord-015365-iqdi99pd 337 34 inhibitors inhibitor NNS cord-015365-iqdi99pd 337 35 after after IN cord-015365-iqdi99pd 337 36 organ organ NN cord-015365-iqdi99pd 337 37 transplantation transplantation NN cord-015365-iqdi99pd 337 38 . . . cord-015365-iqdi99pd 338 1 Background background NN cord-015365-iqdi99pd 338 2 . . . cord-015365-iqdi99pd 339 1 Brain brain NN cord-015365-iqdi99pd 339 2 death death NN cord-015365-iqdi99pd 339 3 ( ( -LRB- cord-015365-iqdi99pd 339 4 BD BD NNP cord-015365-iqdi99pd 339 5 ) ) -RRB- cord-015365-iqdi99pd 339 6 triggers trigger VBZ cord-015365-iqdi99pd 339 7 inflammatory inflammatory JJ cord-015365-iqdi99pd 339 8 signals signal NNS cord-015365-iqdi99pd 339 9 and and CC cord-015365-iqdi99pd 339 10 graft graft NN cord-015365-iqdi99pd 339 11 injury injury NN cord-015365-iqdi99pd 339 12 . . . cord-015365-iqdi99pd 340 1 Clinically clinically RB cord-015365-iqdi99pd 340 2 , , , cord-015365-iqdi99pd 340 3 reduced reduce VBN cord-015365-iqdi99pd 340 4 organ organ NN cord-015365-iqdi99pd 340 5 quality quality NN cord-015365-iqdi99pd 340 6 as as IN cord-015365-iqdi99pd 340 7 a a DT cord-015365-iqdi99pd 340 8 result result NN cord-015365-iqdi99pd 340 9 of of IN cord-015365-iqdi99pd 340 10 brain brain NN cord-015365-iqdi99pd 340 11 death death NN cord-015365-iqdi99pd 340 12 contributes contribute VBZ cord-015365-iqdi99pd 340 13 to to IN cord-015365-iqdi99pd 340 14 inferior inferior JJ cord-015365-iqdi99pd 340 15 graft graft NN cord-015365-iqdi99pd 340 16 and and CC cord-015365-iqdi99pd 340 17 patient patient JJ cord-015365-iqdi99pd 340 18 survival survival NN cord-015365-iqdi99pd 340 19 . . . cord-015365-iqdi99pd 341 1 Regulatory regulatory JJ cord-015365-iqdi99pd 341 2 T t NN cord-015365-iqdi99pd 341 3 - - HYPH cord-015365-iqdi99pd 341 4 cells cell NNS cord-015365-iqdi99pd 341 5 are be VBP cord-015365-iqdi99pd 341 6 primarily primarily RB cord-015365-iqdi99pd 341 7 known know VBN cord-015365-iqdi99pd 341 8 for for IN cord-015365-iqdi99pd 341 9 their -PRON- PRP$ cord-015365-iqdi99pd 341 10 control control NN cord-015365-iqdi99pd 341 11 of of IN cord-015365-iqdi99pd 341 12 the the DT cord-015365-iqdi99pd 341 13 immune immune JJ cord-015365-iqdi99pd 341 14 response response NN cord-015365-iqdi99pd 341 15 . . . cord-015365-iqdi99pd 342 1 We -PRON- PRP cord-015365-iqdi99pd 342 2 analyzed analyze VBD cord-015365-iqdi99pd 342 3 CD25þ CD25þ NNP cord-015365-iqdi99pd 342 4 / / SYM cord-015365-iqdi99pd 342 5 FoxP3þ FoxP3þ NNP cord-015365-iqdi99pd 342 6 T t NN cord-015365-iqdi99pd 342 7 - - HYPH cord-015365-iqdi99pd 342 8 cell cell NN cord-015365-iqdi99pd 342 9 subpopulations subpopulation NNS cord-015365-iqdi99pd 342 10 in in IN cord-015365-iqdi99pd 342 11 recipients recipient NNS cord-015365-iqdi99pd 342 12 of of IN cord-015365-iqdi99pd 342 13 either either DT cord-015365-iqdi99pd 342 14 brain brain NN cord-015365-iqdi99pd 342 15 dead dead JJ cord-015365-iqdi99pd 342 16 and and CC cord-015365-iqdi99pd 342 17 native native JJ cord-015365-iqdi99pd 342 18 donor donor NN cord-015365-iqdi99pd 342 19 hearts heart NNS cord-015365-iqdi99pd 342 20 . . . cord-015365-iqdi99pd 343 1 To to TO cord-015365-iqdi99pd 343 2 dissect dissect VB cord-015365-iqdi99pd 343 3 the the DT cord-015365-iqdi99pd 343 4 role role NN cord-015365-iqdi99pd 343 5 of of IN cord-015365-iqdi99pd 343 6 donor donor NN cord-015365-iqdi99pd 343 7 immune immune NN cord-015365-iqdi99pd 343 8 competent competent JJ cord-015365-iqdi99pd 343 9 cells cell NNS cord-015365-iqdi99pd 343 10 in in IN cord-015365-iqdi99pd 343 11 communicating communicate VBG cord-015365-iqdi99pd 343 12 inflammatory inflammatory JJ cord-015365-iqdi99pd 343 13 signals signal NNS cord-015365-iqdi99pd 343 14 following follow VBG cord-015365-iqdi99pd 343 15 BD BD NNP cord-015365-iqdi99pd 344 1 we -PRON- PRP cord-015365-iqdi99pd 344 2 performed perform VBD cord-015365-iqdi99pd 344 3 syngeneic syngeneic NNS cord-015365-iqdi99pd 344 4 cardiac cardiac JJ cord-015365-iqdi99pd 344 5 transplants transplant NNS cord-015365-iqdi99pd 344 6 from from IN cord-015365-iqdi99pd 344 7 wildtype wildtype NN cord-015365-iqdi99pd 344 8 and and CC cord-015365-iqdi99pd 344 9 immune immune JJ cord-015365-iqdi99pd 344 10 deficient deficient JJ cord-015365-iqdi99pd 344 11 donors donor NNS cord-015365-iqdi99pd 344 12 . . . cord-015365-iqdi99pd 345 1 Methods method NNS cord-015365-iqdi99pd 345 2 . . . cord-015365-iqdi99pd 346 1 Hearts heart NNS cord-015365-iqdi99pd 346 2 from from IN cord-015365-iqdi99pd 346 3 brain brain NN cord-015365-iqdi99pd 346 4 dead dead JJ cord-015365-iqdi99pd 346 5 wild wild JJ cord-015365-iqdi99pd 346 6 type type NN cord-015365-iqdi99pd 347 1 ( ( -LRB- cord-015365-iqdi99pd 347 2 BD BD NNP cord-015365-iqdi99pd 347 3 / / SYM cord-015365-iqdi99pd 347 4 WT WT NNP cord-015365-iqdi99pd 347 5 ) ) -RRB- cord-015365-iqdi99pd 348 1 C57BL6 c57bl6 NN cord-015365-iqdi99pd 348 2 mice mouse NNS cord-015365-iqdi99pd 348 3 and and CC cord-015365-iqdi99pd 348 4 Rag2 Rag2 NNP cord-015365-iqdi99pd 348 5 / / SYM cord-015365-iqdi99pd 348 6 double double JJ cord-015365-iqdi99pd 348 7 knockout knockout NN cord-015365-iqdi99pd 349 1 ( ( -LRB- cord-015365-iqdi99pd 349 2 BD BD NNP cord-015365-iqdi99pd 349 3 / / SYM cord-015365-iqdi99pd 349 4 KO KO NNP cord-015365-iqdi99pd 349 5 ) ) -RRB- cord-015365-iqdi99pd 350 1 mice mouse NNS cord-015365-iqdi99pd 350 2 were be VBD cord-015365-iqdi99pd 350 3 procured procure VBN cord-015365-iqdi99pd 350 4 3 3 CD cord-015365-iqdi99pd 350 5 hrs hrs NN cord-015365-iqdi99pd 350 6 following follow VBG cord-015365-iqdi99pd 350 7 brain brain NN cord-015365-iqdi99pd 350 8 death death NN cord-015365-iqdi99pd 350 9 induction induction NN cord-015365-iqdi99pd 350 10 and and CC cord-015365-iqdi99pd 350 11 transplanted transplant VBD cord-015365-iqdi99pd 350 12 into into IN cord-015365-iqdi99pd 350 13 WT WT NNP cord-015365-iqdi99pd 350 14 recipients recipient NNS cord-015365-iqdi99pd 350 15 . . . cord-015365-iqdi99pd 351 1 Hearts heart NNS cord-015365-iqdi99pd 351 2 originating originate VBG cord-015365-iqdi99pd 351 3 from from IN cord-015365-iqdi99pd 351 4 native native JJ cord-015365-iqdi99pd 351 5 C57BL6 C57BL6 NNP cord-015365-iqdi99pd 351 6 mice mouse NNS cord-015365-iqdi99pd 351 7 served serve VBD cord-015365-iqdi99pd 351 8 as as IN cord-015365-iqdi99pd 351 9 controls control NNS cord-015365-iqdi99pd 351 10 . . . cord-015365-iqdi99pd 352 1 By by IN cord-015365-iqdi99pd 352 2 3 3 CD cord-015365-iqdi99pd 352 3 days day NNS cord-015365-iqdi99pd 352 4 , , , cord-015365-iqdi99pd 352 5 T t NN cord-015365-iqdi99pd 352 6 - - HYPH cord-015365-iqdi99pd 352 7 lymphocyte lymphocyte NN cord-015365-iqdi99pd 352 8 subpopulations subpopulation NNS cord-015365-iqdi99pd 352 9 ( ( -LRB- cord-015365-iqdi99pd 352 10 CD4 CD4 NNP cord-015365-iqdi99pd 352 11 , , , cord-015365-iqdi99pd 352 12 CD8 CD8 NNP cord-015365-iqdi99pd 352 13 , , , cord-015365-iqdi99pd 352 14 CD4 CD4 NNP cord-015365-iqdi99pd 352 15 / / SYM cord-015365-iqdi99pd 352 16 CD25 CD25 NNP cord-015365-iqdi99pd 352 17 / / SYM cord-015365-iqdi99pd 352 18 FoxP3 FoxP3 NNP cord-015365-iqdi99pd 352 19 ) ) -RRB- cord-015365-iqdi99pd 352 20 were be VBD cord-015365-iqdi99pd 352 21 assessed assess VBN cord-015365-iqdi99pd 352 22 by by IN cord-015365-iqdi99pd 352 23 flow flow NN cord-015365-iqdi99pd 352 24 cytometry cytometry NN cord-015365-iqdi99pd 352 25 and and CC cord-015365-iqdi99pd 352 26 graft graft NN cord-015365-iqdi99pd 352 27 - - HYPH cord-015365-iqdi99pd 352 28 specific specific JJ cord-015365-iqdi99pd 352 29 changes change NNS cord-015365-iqdi99pd 352 30 were be VBD cord-015365-iqdi99pd 352 31 assessed assess VBN cord-015365-iqdi99pd 352 32 by by IN cord-015365-iqdi99pd 352 33 IHC IHC NNP cord-015365-iqdi99pd 352 34 and and CC cord-015365-iqdi99pd 352 35 RT RT NNP cord-015365-iqdi99pd 352 36 - - HYPH cord-015365-iqdi99pd 352 37 PCR PCR NNP cord-015365-iqdi99pd 352 38 . . . cord-015365-iqdi99pd 353 1 Results result NNS cord-015365-iqdi99pd 353 2 . . . cord-015365-iqdi99pd 354 1 Blood blood NN cord-015365-iqdi99pd 354 2 pressure pressure NN cord-015365-iqdi99pd 354 3 remained remain VBD cord-015365-iqdi99pd 354 4 stable stable JJ cord-015365-iqdi99pd 354 5 following follow VBG cord-015365-iqdi99pd 354 6 BD BD NNP cord-015365-iqdi99pd 354 7 induction induction NN cord-015365-iqdi99pd 354 8 and and CC cord-015365-iqdi99pd 354 9 intragraft intragraft NN cord-015365-iqdi99pd 354 10 cell cell NN cord-015365-iqdi99pd 354 11 infiltration infiltration NN cord-015365-iqdi99pd 354 12 was be VBD cord-015365-iqdi99pd 354 13 comparable comparable JJ cord-015365-iqdi99pd 354 14 in in IN cord-015365-iqdi99pd 354 15 all all DT cord-015365-iqdi99pd 354 16 groups group NNS cord-015365-iqdi99pd 354 17 ( ( -LRB- cord-015365-iqdi99pd 354 18 p p NNP cord-015365-iqdi99pd 354 19 ¼ ¼ NNP cord-015365-iqdi99pd 354 20 n.s n.s NNP cord-015365-iqdi99pd 354 21 . . NNP cord-015365-iqdi99pd 354 22 ) ) -RRB- cord-015365-iqdi99pd 354 23 . . . cord-015365-iqdi99pd 355 1 Cardiac cardiac JJ cord-015365-iqdi99pd 355 2 isografts isograft NNS cord-015365-iqdi99pd 355 3 from from IN cord-015365-iqdi99pd 355 4 BD BD NNP cord-015365-iqdi99pd 355 5 / / SYM cord-015365-iqdi99pd 355 6 WT WT NNP cord-015365-iqdi99pd 355 7 donors donor NNS cord-015365-iqdi99pd 355 8 demonstrated demonstrate VBD cord-015365-iqdi99pd 355 9 pronounced pronounced JJ cord-015365-iqdi99pd 355 10 cellular cellular JJ cord-015365-iqdi99pd 355 11 infiltrates infiltrate VBZ cord-015365-iqdi99pd 355 12 ; ; : cord-015365-iqdi99pd 355 13 only only RB cord-015365-iqdi99pd 355 14 few few JJ cord-015365-iqdi99pd 355 15 cells cell NNS cord-015365-iqdi99pd 355 16 infiltrated infiltrate VBD cord-015365-iqdi99pd 355 17 hearts heart NNS cord-015365-iqdi99pd 355 18 from from IN cord-015365-iqdi99pd 355 19 living live VBG cord-015365-iqdi99pd 355 20 WT WT NNP cord-015365-iqdi99pd 355 21 donors donor NNS cord-015365-iqdi99pd 355 22 ( ( -LRB- cord-015365-iqdi99pd 355 23 p p NN cord-015365-iqdi99pd 355 24 ¼ ¼ CD cord-015365-iqdi99pd 355 25 0.025 0.025 CD cord-015365-iqdi99pd 355 26 ) ) -RRB- cord-015365-iqdi99pd 355 27 . . . cord-015365-iqdi99pd 356 1 Of of IN cord-015365-iqdi99pd 356 2 note note NN cord-015365-iqdi99pd 356 3 , , , cord-015365-iqdi99pd 356 4 CD4 CD4 NNP cord-015365-iqdi99pd 356 5 / / SYM cord-015365-iqdi99pd 356 6 CD25 CD25 NNP cord-015365-iqdi99pd 356 7 / / SYM cord-015365-iqdi99pd 356 8 FoxP3 FoxP3 NNP cord-015365-iqdi99pd 356 9 regulatory regulatory JJ cord-015365-iqdi99pd 356 10 T t NN cord-015365-iqdi99pd 356 11 - - HYPH cord-015365-iqdi99pd 356 12 cells cell NNS cord-015365-iqdi99pd 356 13 counts count NNS cord-015365-iqdi99pd 356 14 were be VBD cord-015365-iqdi99pd 356 15 significantly significantly RB cord-015365-iqdi99pd 356 16 elevated elevate VBN cord-015365-iqdi99pd 356 17 in in IN cord-015365-iqdi99pd 356 18 recipients recipient NNS cord-015365-iqdi99pd 356 19 of of IN cord-015365-iqdi99pd 356 20 BD BD NNP cord-015365-iqdi99pd 356 21 / / SYM cord-015365-iqdi99pd 356 22 WT WT NNP cord-015365-iqdi99pd 356 23 grafts graft NNS cord-015365-iqdi99pd 356 24 ( ( -LRB- cord-015365-iqdi99pd 356 25 p p NN cord-015365-iqdi99pd 356 26 ¼ ¼ CD cord-015365-iqdi99pd 356 27 0.04 0.04 CD cord-015365-iqdi99pd 356 28 ) ) -RRB- cord-015365-iqdi99pd 356 29 . . . cord-015365-iqdi99pd 357 1 Recipients recipient NNS cord-015365-iqdi99pd 357 2 of of IN cord-015365-iqdi99pd 357 3 BD BD NNP cord-015365-iqdi99pd 357 4 / / SYM cord-015365-iqdi99pd 357 5 KO KO NNP cord-015365-iqdi99pd 357 6 hearts heart NNS cord-015365-iqdi99pd 357 7 featured feature VBD cord-015365-iqdi99pd 357 8 reduced reduce VBN cord-015365-iqdi99pd 357 9 CD4 CD4 NNP cord-015365-iqdi99pd 357 10 þ þ NNP cord-015365-iqdi99pd 357 11 T t NN cord-015365-iqdi99pd 357 12 - - HYPH cord-015365-iqdi99pd 357 13 cell cell NN cord-015365-iqdi99pd 357 14 infiltrates infiltrate VBZ cord-015365-iqdi99pd 357 15 , , , cord-015365-iqdi99pd 357 16 but but CC cord-015365-iqdi99pd 357 17 comparable comparable JJ cord-015365-iqdi99pd 357 18 FoxP3 FoxP3 NNP cord-015365-iqdi99pd 357 19 levels level NNS cord-015365-iqdi99pd 357 20 ( ( -LRB- cord-015365-iqdi99pd 357 21 p p NN cord-015365-iqdi99pd 357 22 ¼ ¼ NNP cord-015365-iqdi99pd 357 23 n.s n.s NNP cord-015365-iqdi99pd 357 24 . . NNP cord-015365-iqdi99pd 357 25 ) ) -RRB- cord-015365-iqdi99pd 357 26 . . . cord-015365-iqdi99pd 358 1 In in IN cord-015365-iqdi99pd 358 2 contrast contrast NN cord-015365-iqdi99pd 358 3 , , , cord-015365-iqdi99pd 358 4 BD BD NNP cord-015365-iqdi99pd 358 5 / / SYM cord-015365-iqdi99pd 358 6 KO KO NNP cord-015365-iqdi99pd 358 7 heart heart NN cord-015365-iqdi99pd 358 8 recipients recipient NNS cord-015365-iqdi99pd 358 9 showed show VBD cord-015365-iqdi99pd 358 10 significantly significantly RB cord-015365-iqdi99pd 358 11 lower low JJR cord-015365-iqdi99pd 358 12 IL-6 IL-6 NNP cord-015365-iqdi99pd 358 13 , , , cord-015365-iqdi99pd 358 14 IFN- IFN- NNP cord-015365-iqdi99pd 358 15 , , , cord-015365-iqdi99pd 358 16 and and CC cord-015365-iqdi99pd 358 17 TNF TNF NNP cord-015365-iqdi99pd 358 18 -- -- : cord-015365-iqdi99pd 358 19 levels level NNS cord-015365-iqdi99pd 358 20 ( ( -LRB- cord-015365-iqdi99pd 358 21 p p NN cord-015365-iqdi99pd 358 22 ¼ ¼ CD cord-015365-iqdi99pd 358 23 0.03 0.03 CD cord-015365-iqdi99pd 358 24 , , , cord-015365-iqdi99pd 358 25 0.005 0.005 CD cord-015365-iqdi99pd 358 26 , , , cord-015365-iqdi99pd 358 27 0.01 0.01 CD cord-015365-iqdi99pd 358 28 ) ) -RRB- cord-015365-iqdi99pd 358 29 . . . cord-015365-iqdi99pd 359 1 Conclusions conclusion NNS cord-015365-iqdi99pd 359 2 . . . cord-015365-iqdi99pd 360 1 Inflammatory inflammatory JJ cord-015365-iqdi99pd 360 2 events event NNS cord-015365-iqdi99pd 360 3 after after IN cord-015365-iqdi99pd 360 4 brain brain NN cord-015365-iqdi99pd 360 5 death death NN cord-015365-iqdi99pd 360 6 are be VBP cord-015365-iqdi99pd 360 7 counterbalanced counterbalance VBN cord-015365-iqdi99pd 360 8 by by IN cord-015365-iqdi99pd 360 9 significantly significantly RB cord-015365-iqdi99pd 360 10 elevated elevate VBN cord-015365-iqdi99pd 360 11 rates rate NNS cord-015365-iqdi99pd 360 12 of of IN cord-015365-iqdi99pd 360 13 CD4 CD4 NNP cord-015365-iqdi99pd 360 14 / / SYM cord-015365-iqdi99pd 360 15 CD25/ CD25/ NNP cord-015365-iqdi99pd 361 1 FoxP3 FoxP3 NNP cord-015365-iqdi99pd 361 2 reg reg NN cord-015365-iqdi99pd 361 3 . . . cord-015365-iqdi99pd 362 1 T t NN cord-015365-iqdi99pd 362 2 - - HYPH cord-015365-iqdi99pd 362 3 cells cell NNS cord-015365-iqdi99pd 362 4 . . . cord-015365-iqdi99pd 363 1 Less less RBR cord-015365-iqdi99pd 363 2 pronounced pronounced JJ cord-015365-iqdi99pd 363 3 consequences consequence NNS cord-015365-iqdi99pd 363 4 of of IN cord-015365-iqdi99pd 363 5 brain brain NN cord-015365-iqdi99pd 363 6 death death NN cord-015365-iqdi99pd 363 7 in in IN cord-015365-iqdi99pd 363 8 hearts heart NNS cord-015365-iqdi99pd 363 9 originating originate VBG cord-015365-iqdi99pd 363 10 from from IN cord-015365-iqdi99pd 363 11 immune immune JJ cord-015365-iqdi99pd 363 12 deficient deficient JJ cord-015365-iqdi99pd 363 13 donors donor NNS cord-015365-iqdi99pd 363 14 suggest suggest VBP cord-015365-iqdi99pd 363 15 a a DT cord-015365-iqdi99pd 363 16 critical critical JJ cord-015365-iqdi99pd 363 17 role role NN cord-015365-iqdi99pd 363 18 of of IN cord-015365-iqdi99pd 363 19 immune immune JJ cord-015365-iqdi99pd 363 20 competent competent JJ cord-015365-iqdi99pd 363 21 cells cell NNS cord-015365-iqdi99pd 363 22 in in IN cord-015365-iqdi99pd 363 23 communicating communicate VBG cord-015365-iqdi99pd 363 24 inflammatory inflammatory JJ cord-015365-iqdi99pd 363 25 signals signal NNS cord-015365-iqdi99pd 363 26 . . . cord-015365-iqdi99pd 364 1 Lipocalin-2 Lipocalin-2 NNPS cord-015365-iqdi99pd 364 2 as as IN cord-015365-iqdi99pd 364 3 a a DT cord-015365-iqdi99pd 364 4 therapeutic therapeutic JJ cord-015365-iqdi99pd 364 5 agent agent NN cord-015365-iqdi99pd 364 6 in in IN cord-015365-iqdi99pd 364 7 chemotaxis chemotaxis NN cord-015365-iqdi99pd 364 8 during during IN cord-015365-iqdi99pd 364 9 ischemia ischemia NN cord-015365-iqdi99pd 364 10 and and CC cord-015365-iqdi99pd 364 11 reperfusion reperfusion NN cord-015365-iqdi99pd 364 12 injury injury NN cord-015365-iqdi99pd 364 13 following follow VBG cord-015365-iqdi99pd 364 14 solid solid JJ cord-015365-iqdi99pd 364 15 organ organ NN cord-015365-iqdi99pd 364 16 transplantation transplantation NN cord-015365-iqdi99pd 364 17 Background Background NNP cord-015365-iqdi99pd 364 18 . . . cord-015365-iqdi99pd 365 1 Neutrophil Neutrophil NNP cord-015365-iqdi99pd 365 2 gelatinase gelatinase NN cord-015365-iqdi99pd 365 3 - - HYPH cord-015365-iqdi99pd 365 4 associated associate VBN cord-015365-iqdi99pd 365 5 lipocalin lipocalin NN cord-015365-iqdi99pd 366 1 ( ( -LRB- cord-015365-iqdi99pd 366 2 NGAL NGAL NNP cord-015365-iqdi99pd 366 3 / / SYM cord-015365-iqdi99pd 366 4 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 366 5 ) ) -RRB- cord-015365-iqdi99pd 366 6 expression expression NN cord-015365-iqdi99pd 366 7 is be VBZ cord-015365-iqdi99pd 366 8 associated associate VBN cord-015365-iqdi99pd 366 9 with with IN cord-015365-iqdi99pd 366 10 ischemia ischemia NN cord-015365-iqdi99pd 366 11 / / SYM cord-015365-iqdi99pd 366 12 reperfusion reperfusion NN cord-015365-iqdi99pd 366 13 injury injury NN cord-015365-iqdi99pd 366 14 ( ( -LRB- cord-015365-iqdi99pd 366 15 IRI IRI NNP cord-015365-iqdi99pd 366 16 ) ) -RRB- cord-015365-iqdi99pd 366 17 following follow VBG cord-015365-iqdi99pd 366 18 transplantation transplantation NN cord-015365-iqdi99pd 366 19 and and CC cord-015365-iqdi99pd 366 20 correlates correlate VBZ cord-015365-iqdi99pd 366 21 with with IN cord-015365-iqdi99pd 366 22 polymorphonuclear polymorphonuclear JJ cord-015365-iqdi99pd 366 23 cell cell NN cord-015365-iqdi99pd 366 24 infiltration infiltration NN cord-015365-iqdi99pd 366 25 . . . cord-015365-iqdi99pd 367 1 To to TO cord-015365-iqdi99pd 367 2 get get VB cord-015365-iqdi99pd 367 3 insight insight NN cord-015365-iqdi99pd 367 4 into into IN cord-015365-iqdi99pd 367 5 the the DT cord-015365-iqdi99pd 367 6 regulatory regulatory JJ cord-015365-iqdi99pd 367 7 role role NN cord-015365-iqdi99pd 367 8 of of IN cord-015365-iqdi99pd 367 9 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 367 10 during during IN cord-015365-iqdi99pd 367 11 IRI IRI NNP cord-015365-iqdi99pd 367 12 the the DT cord-015365-iqdi99pd 367 13 expression expression NN cord-015365-iqdi99pd 367 14 of of IN cord-015365-iqdi99pd 367 15 different different JJ cord-015365-iqdi99pd 367 16 chemokines chemokine NNS cord-015365-iqdi99pd 367 17 and and CC cord-015365-iqdi99pd 367 18 adhesion adhesion NN cord-015365-iqdi99pd 367 19 molecules molecule NNS cord-015365-iqdi99pd 367 20 were be VBD cord-015365-iqdi99pd 367 21 analyzed analyze VBN cord-015365-iqdi99pd 367 22 in in IN cord-015365-iqdi99pd 367 23 a a DT cord-015365-iqdi99pd 367 24 murine murine JJ cord-015365-iqdi99pd 367 25 heart heart NN cord-015365-iqdi99pd 367 26 transplantation transplantation NN cord-015365-iqdi99pd 367 27 model model NN cord-015365-iqdi99pd 367 28 . . . cord-015365-iqdi99pd 368 1 Methods method NNS cord-015365-iqdi99pd 368 2 . . . cord-015365-iqdi99pd 369 1 The the DT cord-015365-iqdi99pd 369 2 murine murine JJ cord-015365-iqdi99pd 369 3 heterotopic heterotopic NNP cord-015365-iqdi99pd 369 4 heart heart NN cord-015365-iqdi99pd 369 5 transplant transplant NN cord-015365-iqdi99pd 369 6 model model NN cord-015365-iqdi99pd 369 7 also also RB cord-015365-iqdi99pd 369 8 implying imply VBG cord-015365-iqdi99pd 369 9 exogenous exogenous JJ cord-015365-iqdi99pd 369 10 i.p i.p NNP cord-015365-iqdi99pd 369 11 . . NNP cord-015365-iqdi99pd 369 12 application application NN cord-015365-iqdi99pd 369 13 of of IN cord-015365-iqdi99pd 369 14 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 369 15 was be VBD cord-015365-iqdi99pd 369 16 used use VBN cord-015365-iqdi99pd 369 17 for for IN cord-015365-iqdi99pd 369 18 in in IN cord-015365-iqdi99pd 369 19 vivo vivo NN cord-015365-iqdi99pd 369 20 experiments experiment NNS cord-015365-iqdi99pd 369 21 . . . cord-015365-iqdi99pd 370 1 The the DT cord-015365-iqdi99pd 370 2 mRNA mRNA NNP cord-015365-iqdi99pd 370 3 expression expression NN cord-015365-iqdi99pd 370 4 of of IN cord-015365-iqdi99pd 370 5 the the DT cord-015365-iqdi99pd 370 6 chemokines chemokine NNS cord-015365-iqdi99pd 370 7 MIP-2 MIP-2 NNP cord-015365-iqdi99pd 370 8 , , , cord-015365-iqdi99pd 370 9 LIX LIX NNP cord-015365-iqdi99pd 370 10 , , , cord-015365-iqdi99pd 370 11 KC KC NNP cord-015365-iqdi99pd 370 12 , , , cord-015365-iqdi99pd 370 13 MCP-1 MCP-1 NNP cord-015365-iqdi99pd 370 14 , , , cord-015365-iqdi99pd 370 15 IL-6 IL-6 NNP cord-015365-iqdi99pd 370 16 and and CC cord-015365-iqdi99pd 370 17 CCL-6 CCL-6 NNP cord-015365-iqdi99pd 370 18 and and CC cord-015365-iqdi99pd 370 19 their -PRON- PRP$ cord-015365-iqdi99pd 370 20 receptors receptor NNS cord-015365-iqdi99pd 370 21 CXCR2 CXCR2 NNS cord-015365-iqdi99pd 370 22 and and CC cord-015365-iqdi99pd 370 23 CCR2 CCR2 NNP cord-015365-iqdi99pd 370 24 as as RB cord-015365-iqdi99pd 370 25 well well RB cord-015365-iqdi99pd 370 26 as as IN cord-015365-iqdi99pd 370 27 ICAM-1 ICAM-1 NNP cord-015365-iqdi99pd 370 28 was be VBD cord-015365-iqdi99pd 370 29 analyzed analyze VBN cord-015365-iqdi99pd 370 30 by by IN cord-015365-iqdi99pd 370 31 qPCR qPCR NNP cord-015365-iqdi99pd 370 32 . . . cord-015365-iqdi99pd 371 1 Immunohistochemistry Immunohistochemistry NNP cord-015365-iqdi99pd 371 2 was be VBD cord-015365-iqdi99pd 371 3 performed perform VBN cord-015365-iqdi99pd 371 4 in in IN cord-015365-iqdi99pd 371 5 heart heart NN cord-015365-iqdi99pd 371 6 sections section NNS cord-015365-iqdi99pd 371 7 and and CC cord-015365-iqdi99pd 371 8 correlated correlate VBN cord-015365-iqdi99pd 371 9 with with IN cord-015365-iqdi99pd 371 10 neutrophil neutrophil NN cord-015365-iqdi99pd 371 11 infiltration infiltration NN cord-015365-iqdi99pd 371 12 at at IN cord-015365-iqdi99pd 371 13 various various JJ cord-015365-iqdi99pd 371 14 time time NN cord-015365-iqdi99pd 371 15 points point NNS cord-015365-iqdi99pd 371 16 ( ( -LRB- cord-015365-iqdi99pd 371 17 2 2 CD cord-015365-iqdi99pd 371 18 , , , cord-015365-iqdi99pd 371 19 12 12 CD cord-015365-iqdi99pd 371 20 , , , cord-015365-iqdi99pd 371 21 24 24 CD cord-015365-iqdi99pd 371 22 and and CC cord-015365-iqdi99pd 371 23 48 48 CD cord-015365-iqdi99pd 371 24 h h NN cord-015365-iqdi99pd 371 25 ) ) -RRB- cord-015365-iqdi99pd 371 26 . . . cord-015365-iqdi99pd 372 1 Results result NNS cord-015365-iqdi99pd 372 2 . . . cord-015365-iqdi99pd 373 1 Significant significant JJ cord-015365-iqdi99pd 373 2 lower low JJR cord-015365-iqdi99pd 373 3 granulocyte granulocyte NN cord-015365-iqdi99pd 373 4 infiltration infiltration NN cord-015365-iqdi99pd 373 5 and and CC cord-015365-iqdi99pd 373 6 serum serum NN cord-015365-iqdi99pd 373 7 creatinine creatinine NN cord-015365-iqdi99pd 373 8 kinase kinase NN cord-015365-iqdi99pd 373 9 levels level NNS cord-015365-iqdi99pd 373 10 during during IN cord-015365-iqdi99pd 373 11 IRI IRI NNP cord-015365-iqdi99pd 373 12 were be VBD cord-015365-iqdi99pd 373 13 observed observe VBN cord-015365-iqdi99pd 373 14 in in IN cord-015365-iqdi99pd 373 15 the the DT cord-015365-iqdi99pd 373 16 Lcn-2-/transplants lcn-2-/transplant NNS cord-015365-iqdi99pd 373 17 correlating correlate VBG cord-015365-iqdi99pd 373 18 with with IN cord-015365-iqdi99pd 373 19 a a DT cord-015365-iqdi99pd 373 20 stable stable JJ cord-015365-iqdi99pd 373 21 ICAM-1 icam-1 NN cord-015365-iqdi99pd 373 22 expression expression NN cord-015365-iqdi99pd 373 23 compared compare VBN cord-015365-iqdi99pd 373 24 to to IN cord-015365-iqdi99pd 373 25 the the DT cord-015365-iqdi99pd 373 26 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 373 27 wt wt NN cord-015365-iqdi99pd 373 28 setting setting NN cord-015365-iqdi99pd 373 29 ( ( -LRB- cord-015365-iqdi99pd 373 30 > > NFP cord-015365-iqdi99pd 373 31 5fold 5fold CD cord-015365-iqdi99pd 373 32 expression expression NN cord-015365-iqdi99pd 373 33 at at IN cord-015365-iqdi99pd 373 34 2 2 CD cord-015365-iqdi99pd 373 35 h h NN cord-015365-iqdi99pd 373 36 of of IN cord-015365-iqdi99pd 373 37 reperfusion reperfusion NN cord-015365-iqdi99pd 373 38 ) ) -RRB- cord-015365-iqdi99pd 373 39 . . . cord-015365-iqdi99pd 374 1 In in IN cord-015365-iqdi99pd 374 2 the the DT cord-015365-iqdi99pd 374 3 early early JJ cord-015365-iqdi99pd 374 4 phase phase NN cord-015365-iqdi99pd 374 5 of of IN cord-015365-iqdi99pd 374 6 reperfusion reperfusion NN cord-015365-iqdi99pd 374 7 ( ( -LRB- cord-015365-iqdi99pd 374 8 2 2 CD cord-015365-iqdi99pd 374 9 h h NN cord-015365-iqdi99pd 374 10 ) ) -RRB- cord-015365-iqdi99pd 374 11 MCP-1 MCP-1 NNP cord-015365-iqdi99pd 374 12 , , , cord-015365-iqdi99pd 374 13 KC KC NNP cord-015365-iqdi99pd 374 14 , , , cord-015365-iqdi99pd 374 15 LIX LIX NNP cord-015365-iqdi99pd 374 16 and and CC cord-015365-iqdi99pd 374 17 MIP-2 MIP-2 NNP cord-015365-iqdi99pd 374 18 showed show VBD cord-015365-iqdi99pd 374 19 a a DT cord-015365-iqdi99pd 374 20 lower low JJR cord-015365-iqdi99pd 374 21 expression expression NN cord-015365-iqdi99pd 374 22 pattern pattern NN cord-015365-iqdi99pd 374 23 in in IN cord-015365-iqdi99pd 374 24 the the DT cord-015365-iqdi99pd 374 25 Lcn-2-/transplants Lcn-2-/transplants NNPS cord-015365-iqdi99pd 374 26 with with IN cord-015365-iqdi99pd 374 27 delayed delay VBN cord-015365-iqdi99pd 374 28 upregulation upregulation NN cord-015365-iqdi99pd 374 29 at at IN cord-015365-iqdi99pd 374 30 12 12 CD cord-015365-iqdi99pd 374 31 h h NN cord-015365-iqdi99pd 374 32 ( ( -LRB- cord-015365-iqdi99pd 374 33 LIX LIX NNP cord-015365-iqdi99pd 374 34 , , , cord-015365-iqdi99pd 374 35 MIP-2 MIP-2 NNP cord-015365-iqdi99pd 374 36 ) ) -RRB- cord-015365-iqdi99pd 374 37 . . . cord-015365-iqdi99pd 375 1 After after IN cord-015365-iqdi99pd 375 2 i.p i.p NNP cord-015365-iqdi99pd 375 3 . . . cord-015365-iqdi99pd 376 1 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 376 2 application application VB cord-015365-iqdi99pd 376 3 no no DT cord-015365-iqdi99pd 376 4 significant significant JJ cord-015365-iqdi99pd 376 5 difference difference NN cord-015365-iqdi99pd 376 6 in in IN cord-015365-iqdi99pd 376 7 apoptosis apoptosis NN cord-015365-iqdi99pd 376 8 was be VBD cord-015365-iqdi99pd 376 9 observed observe VBN cord-015365-iqdi99pd 376 10 . . . cord-015365-iqdi99pd 377 1 The the DT cord-015365-iqdi99pd 377 2 number number NN cord-015365-iqdi99pd 377 3 of of IN cord-015365-iqdi99pd 377 4 infiltrating infiltrate VBG cord-015365-iqdi99pd 377 5 granulocytes granulocyte NNS cord-015365-iqdi99pd 377 6 was be VBD cord-015365-iqdi99pd 377 7 reduced reduce VBN cord-015365-iqdi99pd 377 8 after after IN cord-015365-iqdi99pd 377 9 application application NN cord-015365-iqdi99pd 377 10 of of IN cord-015365-iqdi99pd 377 11 the the DT cord-015365-iqdi99pd 377 12 iron iron NN cord-015365-iqdi99pd 377 13 - - HYPH cord-015365-iqdi99pd 377 14 loaded load VBN cord-015365-iqdi99pd 377 15 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 377 16 compared compare VBN cord-015365-iqdi99pd 377 17 to to IN cord-015365-iqdi99pd 377 18 iron iron NN cord-015365-iqdi99pd 377 19 - - HYPH cord-015365-iqdi99pd 377 20 free free JJ cord-015365-iqdi99pd 377 21 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 377 22 . . . cord-015365-iqdi99pd 377 23 Conclusions conclusion NNS cord-015365-iqdi99pd 377 24 . . . cord-015365-iqdi99pd 378 1 Our -PRON- PRP$ cord-015365-iqdi99pd 378 2 data data NN cord-015365-iqdi99pd 378 3 point point NN cord-015365-iqdi99pd 378 4 to to IN cord-015365-iqdi99pd 378 5 a a DT cord-015365-iqdi99pd 378 6 possible possible JJ cord-015365-iqdi99pd 378 7 chemotactic chemotactic JJ cord-015365-iqdi99pd 378 8 role role NN cord-015365-iqdi99pd 378 9 of of IN cord-015365-iqdi99pd 378 10 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 378 11 which which WDT cord-015365-iqdi99pd 378 12 may may MD cord-015365-iqdi99pd 378 13 also also RB cord-015365-iqdi99pd 378 14 affect affect VB cord-015365-iqdi99pd 378 15 the the DT cord-015365-iqdi99pd 378 16 expression expression NN cord-015365-iqdi99pd 378 17 of of IN cord-015365-iqdi99pd 378 18 particular particular JJ cord-015365-iqdi99pd 378 19 chemokines chemokine NNS cord-015365-iqdi99pd 378 20 in in IN cord-015365-iqdi99pd 378 21 the the DT cord-015365-iqdi99pd 378 22 early early JJ cord-015365-iqdi99pd 378 23 phase phase NN cord-015365-iqdi99pd 378 24 of of IN cord-015365-iqdi99pd 378 25 IRI IRI NNP cord-015365-iqdi99pd 378 26 . . . cord-015365-iqdi99pd 379 1 The the DT cord-015365-iqdi99pd 379 2 role role NN cord-015365-iqdi99pd 379 3 of of IN cord-015365-iqdi99pd 379 4 the the DT cord-015365-iqdi99pd 379 5 iron iron NN cord-015365-iqdi99pd 379 6 binding binding NN cord-015365-iqdi99pd 379 7 capacity capacity NN cord-015365-iqdi99pd 379 8 of of IN cord-015365-iqdi99pd 379 9 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 379 10 in in IN cord-015365-iqdi99pd 379 11 chemotaxis chemotaxis NN cord-015365-iqdi99pd 379 12 during during IN cord-015365-iqdi99pd 379 13 IRI IRI NNP cord-015365-iqdi99pd 379 14 is be VBZ cord-015365-iqdi99pd 379 15 still still RB cord-015365-iqdi99pd 379 16 unknown unknown JJ cord-015365-iqdi99pd 379 17 . . . cord-015365-iqdi99pd 380 1 Understanding understand VBG cord-015365-iqdi99pd 380 2 these these DT cord-015365-iqdi99pd 380 3 regulatory regulatory JJ cord-015365-iqdi99pd 380 4 mechanisms mechanism NNS cord-015365-iqdi99pd 380 5 will will MD cord-015365-iqdi99pd 380 6 be be VB cord-015365-iqdi99pd 380 7 crucial crucial JJ cord-015365-iqdi99pd 380 8 to to TO cord-015365-iqdi99pd 380 9 establish establish VB cord-015365-iqdi99pd 380 10 treatment treatment NN cord-015365-iqdi99pd 380 11 strategies strategy NNS cord-015365-iqdi99pd 380 12 for for IN cord-015365-iqdi99pd 380 13 IRI IRI NNP cord-015365-iqdi99pd 380 14 during during IN cord-015365-iqdi99pd 380 15 solid solid JJ cord-015365-iqdi99pd 380 16 organ organ NN cord-015365-iqdi99pd 380 17 transplantation transplantation NN cord-015365-iqdi99pd 380 18 . . . cord-015365-iqdi99pd 381 1 Glomeruläre Glomeruläre NNP cord-015365-iqdi99pd 381 2 Effekte Effekte NNP cord-015365-iqdi99pd 381 3 des des FW cord-015365-iqdi99pd 381 4 mTOR mTOR NNP cord-015365-iqdi99pd 381 5 - - HYPH cord-015365-iqdi99pd 381 6 Inhibitors Inhibitors NNP cord-015365-iqdi99pd 381 7 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 381 8 in in IN cord-015365-iqdi99pd 381 9 der der NNP cord-015365-iqdi99pd 381 10 nephrotoxischen nephrotoxischen NNP cord-015365-iqdi99pd 381 11 Serumnephritis Serumnephritis NNP cord-015365-iqdi99pd 381 12 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 381 13 . . . cord-015365-iqdi99pd 382 1 Der Der NNP cord-015365-iqdi99pd 382 2 mTOR mTOR NNP cord-015365-iqdi99pd 382 3 Inihibitor Inihibitor NNP cord-015365-iqdi99pd 382 4 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 382 5 ist ist NN cord-015365-iqdi99pd 382 6 ein ein NNP cord-015365-iqdi99pd 382 7 Immunosuppressivum Immunosuppressivum NNP cord-015365-iqdi99pd 382 8 , , , cord-015365-iqdi99pd 382 9 welches welches NNP cord-015365-iqdi99pd 382 10 klinische klinische NNP cord-015365-iqdi99pd 382 11 Anwendung Anwendung NNP cord-015365-iqdi99pd 382 12 zur zur NNP cord-015365-iqdi99pd 382 13 Prävention Prävention NNP cord-015365-iqdi99pd 382 14 von von NNP cord-015365-iqdi99pd 382 15 Abstossungsreaktionen Abstossungsreaktionen NNP cord-015365-iqdi99pd 382 16 bei bei NNP cord-015365-iqdi99pd 382 17 nierentransplantierten nierentransplantierten NNP cord-015365-iqdi99pd 383 1 Patienten Patienten NNP cord-015365-iqdi99pd 383 2 gefunden gefunden NN cord-015365-iqdi99pd 383 3 hat hat NN cord-015365-iqdi99pd 383 4 . . . cord-015365-iqdi99pd 384 1 Einer Einer NNP cord-015365-iqdi99pd 384 2 der der NNP cord-015365-iqdi99pd 384 3 limitierenden limitierenden JJ cord-015365-iqdi99pd 384 4 Faktoren Faktoren NNP cord-015365-iqdi99pd 384 5 bei bei NNP cord-015365-iqdi99pd 384 6 der der NNP cord-015365-iqdi99pd 384 7 klinischen klinischen NNP cord-015365-iqdi99pd 384 8 Anwendung Anwendung NNP cord-015365-iqdi99pd 384 9 ist ist NN cord-015365-iqdi99pd 384 10 das das FW cord-015365-iqdi99pd 384 11 de de FW cord-015365-iqdi99pd 384 12 novo novo NNP cord-015365-iqdi99pd 384 13 Auftreten Auftreten NNP cord-015365-iqdi99pd 384 14 von von NNP cord-015365-iqdi99pd 384 15 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 384 16 . . . cord-015365-iqdi99pd 385 1 Ziel Ziel NNP cord-015365-iqdi99pd 385 2 der der NNP cord-015365-iqdi99pd 385 3 Arbeit Arbeit NNP cord-015365-iqdi99pd 385 4 war war NN cord-015365-iqdi99pd 385 5 es es NNP cord-015365-iqdi99pd 385 6 , , , cord-015365-iqdi99pd 385 7 die die VB cord-015365-iqdi99pd 385 8 glomerulären glomerulären NNP cord-015365-iqdi99pd 385 9 Veränderungen Veränderungen NNP cord-015365-iqdi99pd 385 10 der der NNP cord-015365-iqdi99pd 385 11 Rapamycininduzierten Rapamycininduzierten NNP cord-015365-iqdi99pd 385 12 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 385 13 in in IN cord-015365-iqdi99pd 385 14 einem einem NNP cord-015365-iqdi99pd 385 15 experimentellen experimentellen NNP cord-015365-iqdi99pd 385 16 Modell Modell NNP cord-015365-iqdi99pd 385 17 der der NNP cord-015365-iqdi99pd 385 18 nephrotoxischen nephrotoxischen NNP cord-015365-iqdi99pd 385 19 Serumnephritis Serumnephritis NNP cord-015365-iqdi99pd 385 20 ( ( -LRB- cord-015365-iqdi99pd 385 21 NTS NTS NNP cord-015365-iqdi99pd 385 22 ) ) -RRB- cord-015365-iqdi99pd 385 23 näher näher NNP cord-015365-iqdi99pd 385 24 zu zu NNP cord-015365-iqdi99pd 385 25 untersuchen untersuchen NNP cord-015365-iqdi99pd 385 26 . . . cord-015365-iqdi99pd 386 1 Methodik Methodik NNP cord-015365-iqdi99pd 386 2 . . . cord-015365-iqdi99pd 387 1 NTS NTS NNP cord-015365-iqdi99pd 387 2 wurde wurde VBD cord-015365-iqdi99pd 387 3 in in IN cord-015365-iqdi99pd 387 4 C57BL/6 C57BL/6 NNP cord-015365-iqdi99pd 387 5 Mäusen Mäusen NNP cord-015365-iqdi99pd 387 6 induziert induziert NN cord-015365-iqdi99pd 388 1 und und IN cord-015365-iqdi99pd 388 2 die die VBP cord-015365-iqdi99pd 388 3 Gabe Gabe NNP cord-015365-iqdi99pd 388 4 von von NNP cord-015365-iqdi99pd 388 5 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 388 6 in in IN cord-015365-iqdi99pd 388 7 einer einer NNP cord-015365-iqdi99pd 388 8 Dosis Dosis NNP cord-015365-iqdi99pd 388 9 von von NNP cord-015365-iqdi99pd 388 10 0,5 0,5 CD cord-015365-iqdi99pd 389 1 mg mg NNP cord-015365-iqdi99pd 389 2 / / SYM cord-015365-iqdi99pd 389 3 kg kg NNP cord-015365-iqdi99pd 389 4 14 14 CD cord-015365-iqdi99pd 389 5 Tage Tage NNP cord-015365-iqdi99pd 389 6 nach nach NNP cord-015365-iqdi99pd 389 7 Induktion Induktion NNP cord-015365-iqdi99pd 389 8 begonnen begonnen XX cord-015365-iqdi99pd 389 9 . . . cord-015365-iqdi99pd 390 1 Die die VB cord-015365-iqdi99pd 390 2 Mäuse Mäuse NNP cord-015365-iqdi99pd 390 3 wurden wurden NNS cord-015365-iqdi99pd 390 4 am be VBP cord-015365-iqdi99pd 390 5 Tag tag NN cord-015365-iqdi99pd 390 6 35 35 CD cord-015365-iqdi99pd 390 7 sakrifiziert sakrifiziert NN cord-015365-iqdi99pd 390 8 und und NNP cord-015365-iqdi99pd 391 1 Glomeruli Glomeruli NNP cord-015365-iqdi99pd 391 2 zur zur NNP cord-015365-iqdi99pd 391 3 Genexpressionsanalyse Genexpressionsanalyse NNP cord-015365-iqdi99pd 391 4 isoliert isoliert NN cord-015365-iqdi99pd 391 5 . . . cord-015365-iqdi99pd 392 1 Außerdem Außerdem NNP cord-015365-iqdi99pd 392 2 wurde wurde NNP cord-015365-iqdi99pd 392 3 mittels mittels NNPS cord-015365-iqdi99pd 392 4 Immunhistochemie Immunhistochemie NNP cord-015365-iqdi99pd 392 5 die die VBP cord-015365-iqdi99pd 392 6 glomeruläre glomeruläre NNP cord-015365-iqdi99pd 392 7 Expression Expression NNP cord-015365-iqdi99pd 392 8 von von NNP cord-015365-iqdi99pd 392 9 T T NNP cord-015365-iqdi99pd 392 10 - - HYPH cord-015365-iqdi99pd 392 11 Zell-(CD4 Zell-(CD4 NNP cord-015365-iqdi99pd 392 12 ) ) -RRB- cord-015365-iqdi99pd 392 13 , , , cord-015365-iqdi99pd 392 14 Makrophagen-(F4/80 Makrophagen-(F4/80 NNP cord-015365-iqdi99pd 392 15 , , , cord-015365-iqdi99pd 392 16 CD68 CD68 NNP cord-015365-iqdi99pd 392 17 ) ) -RRB- cord-015365-iqdi99pd 392 18 , , , cord-015365-iqdi99pd 392 19 Podocyten-(Nephrin Podocyten-(Nephrin NNP cord-015365-iqdi99pd 392 20 ) ) -RRB- cord-015365-iqdi99pd 392 21 , , , cord-015365-iqdi99pd 392 22 sowie sowie JJ cord-015365-iqdi99pd 392 23 Endothelzellmarkern Endothelzellmarkern NNP cord-015365-iqdi99pd 392 24 ( ( -LRB- cord-015365-iqdi99pd 392 25 CD31 CD31 NNP cord-015365-iqdi99pd 392 26 ) ) -RRB- cord-015365-iqdi99pd 392 27 untersucht untersucht NNP cord-015365-iqdi99pd 392 28 . . . cord-015365-iqdi99pd 393 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 393 2 . . . cord-015365-iqdi99pd 394 1 Mäuse Mäuse NNP cord-015365-iqdi99pd 394 2 , , , cord-015365-iqdi99pd 394 3 die die VBP cord-015365-iqdi99pd 394 4 mit mit NNP cord-015365-iqdi99pd 394 5 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 394 6 ab ab NN cord-015365-iqdi99pd 394 7 Tag Tag NNP cord-015365-iqdi99pd 394 8 14 14 CD cord-015365-iqdi99pd 394 9 behandelt behandelt NNP cord-015365-iqdi99pd 394 10 wurden wurden NNP cord-015365-iqdi99pd 394 11 , , , cord-015365-iqdi99pd 394 12 entwickelten entwickelten NNP cord-015365-iqdi99pd 395 1 eine eine NNP cord-015365-iqdi99pd 395 2 signifikant signifikant NNP cord-015365-iqdi99pd 395 3 erhöhte erhöhte NNP cord-015365-iqdi99pd 396 1 Proteinurie Proteinurie NNP cord-015365-iqdi99pd 397 1 i -PRON- PRP cord-015365-iqdi99pd 397 2 m be VBP cord-015365-iqdi99pd 397 3 Vergleich Vergleich NNP cord-015365-iqdi99pd 397 4 zu zu NNP cord-015365-iqdi99pd 397 5 den den NNP cord-015365-iqdi99pd 397 6 Kontrolltieren Kontrolltieren NNP cord-015365-iqdi99pd 397 7 . . . cord-015365-iqdi99pd 398 1 Dies die VBZ cord-015365-iqdi99pd 398 2 war war NN cord-015365-iqdi99pd 398 3 mit mit NNP cord-015365-iqdi99pd 398 4 einer einer NNP cord-015365-iqdi99pd 398 5 verstärkten verstärkten NNP cord-015365-iqdi99pd 398 6 glomerulären glomerulären NNP cord-015365-iqdi99pd 398 7 Infiltration Infiltration NNP cord-015365-iqdi99pd 398 8 von von NNP cord-015365-iqdi99pd 398 9 CD4-positiven CD4-positiven NNP cord-015365-iqdi99pd 399 1 ( ( -LRB- cord-015365-iqdi99pd 399 2 mittlere mittlere RB cord-015365-iqdi99pd 399 3 intraglomeruläre intraglomeruläre RB cord-015365-iqdi99pd 399 4 positive positive JJ cord-015365-iqdi99pd 400 1 Zellen/50 zellen/50 CD cord-015365-iqdi99pd 400 2 Glomeruli Glomeruli NNP cord-015365-iqdi99pd 400 3 4,43 4,43 CD cord-015365-iqdi99pd 400 4 AE AE NNP cord-015365-iqdi99pd 400 5 0,68 0,68 CD cord-015365-iqdi99pd 400 6 vs vs IN cord-015365-iqdi99pd 400 7 2,23 2,23 CD cord-015365-iqdi99pd 400 8 AE AE NNP cord-015365-iqdi99pd 400 9 0,57 0,57 CD cord-015365-iqdi99pd 400 10 ; ; . cord-015365-iqdi99pd 401 1 p p NN cord-015365-iqdi99pd 401 2 < < XX cord-015365-iqdi99pd 401 3 0,05 0,05 NNP cord-015365-iqdi99pd 401 4 ) ) -RRB- cord-015365-iqdi99pd 401 5 , , , cord-015365-iqdi99pd 401 6 F4/80-positiven F4/80-positiven NNP cord-015365-iqdi99pd 401 7 ( ( -LRB- cord-015365-iqdi99pd 401 8 8,2 8,2 CD cord-015365-iqdi99pd 401 9 AE AE NNP cord-015365-iqdi99pd 401 10 1,58 1,58 CD cord-015365-iqdi99pd 401 11 vs. vs. IN cord-015365-iqdi99pd 401 12 3,64 3,64 CD cord-015365-iqdi99pd 401 13 AE AE NNP cord-015365-iqdi99pd 401 14 0,74 0,74 CD cord-015365-iqdi99pd 401 15 ; ; : cord-015365-iqdi99pd 401 16 p p NN cord-015365-iqdi99pd 401 17 < < XX cord-015365-iqdi99pd 401 18 0,05 0,05 XX cord-015365-iqdi99pd 401 19 ) ) -RRB- cord-015365-iqdi99pd 402 1 und und IN cord-015365-iqdi99pd 402 2 CD68-positiven CD68-positiven NNP cord-015365-iqdi99pd 402 3 Zellen Zellen NNP cord-015365-iqdi99pd 402 4 ( ( -LRB- cord-015365-iqdi99pd 402 5 18,80 18,80 CD cord-015365-iqdi99pd 402 6 AE AE NNP cord-015365-iqdi99pd 402 7 3,05 3,05 NN cord-015365-iqdi99pd 402 8 vs. vs. NN cord-015365-iqdi99pd 402 9 9,15AE 9,15ae CD cord-015365-iqdi99pd 402 10 1,61 1,61 CD cord-015365-iqdi99pd 402 11 ; ; : cord-015365-iqdi99pd 402 12 p p NN cord-015365-iqdi99pd 402 13 < < XX cord-015365-iqdi99pd 402 14 0,05 0,05 NN cord-015365-iqdi99pd 402 15 ; ; : cord-015365-iqdi99pd 402 16 n n NN cord-015365-iqdi99pd 402 17 ¼ ¼ NNP cord-015365-iqdi99pd 402 18 13 13 CD cord-015365-iqdi99pd 402 19 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 402 20 , , , cord-015365-iqdi99pd 402 21 n n NN cord-015365-iqdi99pd 402 22 ¼ ¼ CD cord-015365-iqdi99pd 402 23 12 12 CD cord-015365-iqdi99pd 402 24 Vehikel Vehikel NNP cord-015365-iqdi99pd 402 25 ) ) -RRB- cord-015365-iqdi99pd 402 26 assoziiert assoziiert NNP cord-015365-iqdi99pd 402 27 . . . cord-015365-iqdi99pd 403 1 Keine Keine NNP cord-015365-iqdi99pd 403 2 Unterschiede Unterschiede NNP cord-015365-iqdi99pd 403 3 fanden fanden NNP cord-015365-iqdi99pd 403 4 sich sich NNP cord-015365-iqdi99pd 403 5 in in IN cord-015365-iqdi99pd 403 6 der der NNP cord-015365-iqdi99pd 403 7 glomerulären glomerulären NNP cord-015365-iqdi99pd 403 8 Färbung Färbung NNP cord-015365-iqdi99pd 403 9 von von NNP cord-015365-iqdi99pd 403 10 Nephrin Nephrin NNP cord-015365-iqdi99pd 403 11 und und IN cord-015365-iqdi99pd 403 12 CD31 CD31 NNP cord-015365-iqdi99pd 403 13 . . . cord-015365-iqdi99pd 404 1 Real real JJ cord-015365-iqdi99pd 404 2 - - HYPH cord-015365-iqdi99pd 404 3 time time NN cord-015365-iqdi99pd 404 4 PCR PCR NNP cord-015365-iqdi99pd 404 5 der der NN cord-015365-iqdi99pd 404 6 aus aus NNP cord-015365-iqdi99pd 404 7 Glomeruli Glomeruli NNP cord-015365-iqdi99pd 404 8 gewonnenen gewonnenen NNP cord-015365-iqdi99pd 404 9 RNA RNA NNP cord-015365-iqdi99pd 404 10 zeigte zeigte NNP cord-015365-iqdi99pd 404 11 , , , cord-015365-iqdi99pd 404 12 dass dass NNP cord-015365-iqdi99pd 404 13 die die VBP cord-015365-iqdi99pd 405 1 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 405 2 - - HYPH cord-015365-iqdi99pd 405 3 Behandlung Behandlung NNP cord-015365-iqdi99pd 405 4 zu zu NNP cord-015365-iqdi99pd 406 1 einer einer NNP cord-015365-iqdi99pd 407 1 verstärkten verstärkten NNP cord-015365-iqdi99pd 407 2 Expression Expression NNP cord-015365-iqdi99pd 407 3 der der NN cord-015365-iqdi99pd 407 4 proinflammatorischen proinflammatorischen NN cord-015365-iqdi99pd 407 5 Zytokine Zytokine NNP cord-015365-iqdi99pd 408 1 IL-6 IL-6 NNP cord-015365-iqdi99pd 408 2 ( ( -LRB- cord-015365-iqdi99pd 408 3 12,0 12,0 CD cord-015365-iqdi99pd 408 4 AE AE NNP cord-015365-iqdi99pd 408 5 5,2 5,2 CD cord-015365-iqdi99pd 408 6 vs. vs. NN cord-015365-iqdi99pd 408 7 1,0 1,0 CD cord-015365-iqdi99pd 408 8 AE AE NNP cord-015365-iqdi99pd 408 9 0,1 0,1 CD cord-015365-iqdi99pd 408 10 ; ; : cord-015365-iqdi99pd 408 11 p p NN cord-015365-iqdi99pd 408 12 < < XX cord-015365-iqdi99pd 408 13 0,05 0,05 XX cord-015365-iqdi99pd 408 14 ) ) -RRB- cord-015365-iqdi99pd 409 1 und und NNP cord-015365-iqdi99pd 410 1 TNF-(3,4 TNF-(3,4 NNP cord-015365-iqdi99pd 410 2 AE AE NNP cord-015365-iqdi99pd 410 3 1,0 1,0 CD cord-015365-iqdi99pd 410 4 vs. vs. NN cord-015365-iqdi99pd 410 5 1,0AE 1,0ae CD cord-015365-iqdi99pd 410 6 0,1 0,1 CD cord-015365-iqdi99pd 410 7 ; ; : cord-015365-iqdi99pd 410 8 p p NN cord-015365-iqdi99pd 410 9 < < XX cord-015365-iqdi99pd 410 10 0,05 0,05 XX cord-015365-iqdi99pd 410 11 ) ) -RRB- cord-015365-iqdi99pd 411 1 führte führte NNP cord-015365-iqdi99pd 411 2 , , , cord-015365-iqdi99pd 411 3 während während NNP cord-015365-iqdi99pd 411 4 sich sich NNP cord-015365-iqdi99pd 411 5 hierbei hierbei NNP cord-015365-iqdi99pd 411 6 keine keine NNP cord-015365-iqdi99pd 411 7 Hinweise Hinweise NNP cord-015365-iqdi99pd 411 8 auf auf NNP cord-015365-iqdi99pd 411 9 eine eine NNP cord-015365-iqdi99pd 411 10 Schädigung Schädigung NNP cord-015365-iqdi99pd 411 11 der der NNP cord-015365-iqdi99pd 411 12 Endothelzellen Endothelzellen NNP cord-015365-iqdi99pd 411 13 ergab ergab NN cord-015365-iqdi99pd 411 14 . . . cord-015365-iqdi99pd 412 1 Außerdem Außerdem NNP cord-015365-iqdi99pd 412 2 fand fand UH cord-015365-iqdi99pd 412 3 sich sich NNP cord-015365-iqdi99pd 412 4 eine eine NNP cord-015365-iqdi99pd 412 5 gesteigerte gesteigerte NNPS cord-015365-iqdi99pd 412 6 glomeruläre glomeruläre NNP cord-015365-iqdi99pd 412 7 Expression Expression NNP cord-015365-iqdi99pd 412 8 des des FW cord-015365-iqdi99pd 412 9 Transkriptionsfaktors Transkriptionsfaktors NNP cord-015365-iqdi99pd 413 1 Foxp3 Foxp3 NNP cord-015365-iqdi99pd 413 2 . . . cord-015365-iqdi99pd 414 1 Bei Bei NNP cord-015365-iqdi99pd 414 2 TX TX NNP cord-015365-iqdi99pd 414 3 - - HYPH cord-015365-iqdi99pd 414 4 Patienten Patienten NNP cord-015365-iqdi99pd 414 5 / / SYM cord-015365-iqdi99pd 414 6 innen innen NNP cord-015365-iqdi99pd 414 7 findet findet NNP cord-015365-iqdi99pd 414 8 man man NN cord-015365-iqdi99pd 415 1 eine eine NNP cord-015365-iqdi99pd 415 2 bis bis NNP cord-015365-iqdi99pd 415 3 zu zu NNP cord-015365-iqdi99pd 415 4 200-fache 200-fache CD cord-015365-iqdi99pd 415 5 Erhöhung Erhöhung NNP cord-015365-iqdi99pd 415 6 der der NNP cord-015365-iqdi99pd 415 7 sog sog NNP cord-015365-iqdi99pd 415 8 . . . cord-015365-iqdi99pd 416 1 , , , cord-015365-iqdi99pd 416 2 non non JJ cord-015365-iqdi99pd 416 3 - - JJ cord-015365-iqdi99pd 416 4 melanoma melanoma JJ cord-015365-iqdi99pd 416 5 skin skin NN cord-015365-iqdi99pd 416 6 cancer'-Gruppe cancer'-Gruppe NNS cord-015365-iqdi99pd 416 7 und und NNP cord-015365-iqdi99pd 416 8 eine eine NNP cord-015365-iqdi99pd 416 9 5-fache 5-fache CD cord-015365-iqdi99pd 417 1 Steigerung Steigerung NNP cord-015365-iqdi99pd 417 2 der der NNP cord-015365-iqdi99pd 417 3 Melanom Melanom NNP cord-015365-iqdi99pd 417 4 - - HYPH cord-015365-iqdi99pd 417 5 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 418 1 i -PRON- PRP cord-015365-iqdi99pd 418 2 m be VBP cord-015365-iqdi99pd 419 1 Vergleich Vergleich NNP cord-015365-iqdi99pd 419 2 zur zur NNP cord-015365-iqdi99pd 419 3 Normalbevölkerung Normalbevölkerung NNP cord-015365-iqdi99pd 419 4 . . . cord-015365-iqdi99pd 420 1 Das Das NNP cord-015365-iqdi99pd 420 2 klinische klinische NNP cord-015365-iqdi99pd 421 1 Bild Bild NNP cord-015365-iqdi99pd 421 2 dieser dieser NNP cord-015365-iqdi99pd 422 1 Neoplasien Neoplasien NNP cord-015365-iqdi99pd 422 2 ist ist NN cord-015365-iqdi99pd 422 3 nicht nicht NNP cord-015365-iqdi99pd 422 4 selten selten NNP cord-015365-iqdi99pd 422 5 atypisch atypisch NNP cord-015365-iqdi99pd 422 6 , , , cord-015365-iqdi99pd 423 1 das das NNP cord-015365-iqdi99pd 423 2 Verhalten Verhalten NNP cord-015365-iqdi99pd 423 3 aggressiv aggressiv NNP cord-015365-iqdi99pd 423 4 und und IN cord-015365-iqdi99pd 423 5 die die VBP cord-015365-iqdi99pd 423 6 Prognose Prognose NNP cord-015365-iqdi99pd 423 7 ungünstig ungünstig NN cord-015365-iqdi99pd 423 8 . . . cord-015365-iqdi99pd 424 1 Die die VB cord-015365-iqdi99pd 424 2 Intensität Intensität NNP cord-015365-iqdi99pd 424 3 bzw bzw NNP cord-015365-iqdi99pd 424 4 . . . cord-015365-iqdi99pd 425 1 Dauer Dauer NNP cord-015365-iqdi99pd 425 2 der der NN cord-015365-iqdi99pd 425 3 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 426 1 und und NNP cord-015365-iqdi99pd 426 2 die die VB cord-015365-iqdi99pd 426 3 Wahl Wahl NNP cord-015365-iqdi99pd 426 4 der der NNP cord-015365-iqdi99pd 426 5 immunsuppressiven immunsuppressiven NNP cord-015365-iqdi99pd 426 6 Medikamente Medikamente NNP cord-015365-iqdi99pd 426 7 in in IN cord-015365-iqdi99pd 426 8 Verbindung Verbindung NNP cord-015365-iqdi99pd 426 9 mit mit NNP cord-015365-iqdi99pd 426 10 der der NNP cord-015365-iqdi99pd 426 11 aktuellen aktuellen NNP cord-015365-iqdi99pd 426 12 und und IN cord-015365-iqdi99pd 426 13 zurückliegenden zurückliegenden NNP cord-015365-iqdi99pd 426 14 UV UV NNP cord-015365-iqdi99pd 426 15 - - HYPH cord-015365-iqdi99pd 426 16 Exposition exposition NN cord-015365-iqdi99pd 426 17 korreliert korreliert NN cord-015365-iqdi99pd 426 18 dabei dabei NNP cord-015365-iqdi99pd 426 19 mit mit NNP cord-015365-iqdi99pd 426 20 der der NNP cord-015365-iqdi99pd 426 21 Tumorentstehung Tumorentstehung NNP cord-015365-iqdi99pd 426 22 . . . cord-015365-iqdi99pd 427 1 Besonders Besonders NNP cord-015365-iqdi99pd 427 2 wichtig wichtig NNP cord-015365-iqdi99pd 427 3 sind sind VBP cord-015365-iqdi99pd 427 4 regelmäßige regelmäßige NNS cord-015365-iqdi99pd 428 1 Nachsorge Nachsorge NNP cord-015365-iqdi99pd 428 2 - - HYPH cord-015365-iqdi99pd 428 3 Untersuchungen Untersuchungen NNP cord-015365-iqdi99pd 428 4 post post NN cord-015365-iqdi99pd 428 5 Transplantation Transplantation NNP cord-015365-iqdi99pd 428 6 , , , cord-015365-iqdi99pd 428 7 welche welche NNP cord-015365-iqdi99pd 428 8 in in IN cord-015365-iqdi99pd 428 9 speziellen speziellen NNP cord-015365-iqdi99pd 428 10 dermatologischen dermatologischen NNP cord-015365-iqdi99pd 428 11 Ambulanzen Ambulanzen NNP cord-015365-iqdi99pd 428 12 durchgeführt durchgeführt NN cord-015365-iqdi99pd 428 13 werden werden NNP cord-015365-iqdi99pd 428 14 sollten sollten NNP cord-015365-iqdi99pd 428 15 . . . cord-015365-iqdi99pd 429 1 Hierbei Hierbei NNP cord-015365-iqdi99pd 429 2 stehen stehen NNP cord-015365-iqdi99pd 429 3 heute heute NNP cord-015365-iqdi99pd 429 4 moderne moderne NNP cord-015365-iqdi99pd 429 5 Hauttumor Hauttumor NNP cord-015365-iqdi99pd 429 6 - - HYPH cord-015365-iqdi99pd 429 7 Therapieformen Therapieformen NNP cord-015365-iqdi99pd 429 8 ( ( -LRB- cord-015365-iqdi99pd 429 9 , , , cord-015365-iqdi99pd 429 10 targeted target VBN cord-015365-iqdi99pd 429 11 ' ' '' cord-015365-iqdi99pd 429 12 therapy therapy NN cord-015365-iqdi99pd 429 13 und und IN cord-015365-iqdi99pd 429 14 Immunmodulatoren Immunmodulatoren NNP cord-015365-iqdi99pd 429 15 ) ) -RRB- cord-015365-iqdi99pd 430 1 zur zur NNP cord-015365-iqdi99pd 430 2 Verfügung Verfügung NNP cord-015365-iqdi99pd 430 3 . . . cord-015365-iqdi99pd 431 1 Background background NN cord-015365-iqdi99pd 431 2 . . . cord-015365-iqdi99pd 432 1 We -PRON- PRP cord-015365-iqdi99pd 432 2 compared compare VBD cord-015365-iqdi99pd 432 3 steady steady JJ cord-015365-iqdi99pd 432 4 state state NN cord-015365-iqdi99pd 432 5 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 432 6 of of IN cord-015365-iqdi99pd 432 7 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 432 8 mofetil mofetil NNP cord-015365-iqdi99pd 433 1 -Myfenax -myfenax RB cord-015365-iqdi99pd 433 2 + + CC cord-015365-iqdi99pd 434 1 ( ( -LRB- cord-015365-iqdi99pd 434 2 Teva Teva NNP cord-015365-iqdi99pd 434 3 ) ) -RRB- cord-015365-iqdi99pd 434 4 and and CC cord-015365-iqdi99pd 434 5 CellCept CellCept NNP cord-015365-iqdi99pd 434 6 + + CC cord-015365-iqdi99pd 434 7 ( ( -LRB- cord-015365-iqdi99pd 434 8 Roche Roche NNP cord-015365-iqdi99pd 434 9 ) ) -RRB- cord-015365-iqdi99pd 435 1 -in -in : cord-015365-iqdi99pd 435 2 stable stable JJ cord-015365-iqdi99pd 435 3 kidney kidney NN cord-015365-iqdi99pd 435 4 transplant transplant NN cord-015365-iqdi99pd 435 5 recipients recipient NNS cord-015365-iqdi99pd 435 6 ( ( -LRB- cord-015365-iqdi99pd 435 7 KTR KTR NNP cord-015365-iqdi99pd 435 8 ) ) -RRB- cord-015365-iqdi99pd 435 9 . . . cord-015365-iqdi99pd 436 1 Methods method NNS cord-015365-iqdi99pd 436 2 . . . cord-015365-iqdi99pd 437 1 This this DT cord-015365-iqdi99pd 437 2 was be VBD cord-015365-iqdi99pd 437 3 an an DT cord-015365-iqdi99pd 437 4 international international JJ cord-015365-iqdi99pd 437 5 , , , cord-015365-iqdi99pd 437 6 multi multi JJ cord-015365-iqdi99pd 437 7 - - JJ cord-015365-iqdi99pd 437 8 centre centre JJ cord-015365-iqdi99pd 437 9 , , , cord-015365-iqdi99pd 437 10 randomized randomized JJ cord-015365-iqdi99pd 437 11 , , , cord-015365-iqdi99pd 437 12 open open JJ cord-015365-iqdi99pd 437 13 - - HYPH cord-015365-iqdi99pd 437 14 label label NN cord-015365-iqdi99pd 437 15 , , , cord-015365-iqdi99pd 437 16 two two CD cord-015365-iqdi99pd 437 17 - - HYPH cord-015365-iqdi99pd 437 18 treatment treatment NN cord-015365-iqdi99pd 437 19 , , , cord-015365-iqdi99pd 437 20 two two CD cord-015365-iqdi99pd 437 21 - - HYPH cord-015365-iqdi99pd 437 22 sequence sequence NN cord-015365-iqdi99pd 437 23 crossover crossover NN cord-015365-iqdi99pd 437 24 study study NN cord-015365-iqdi99pd 437 25 with with IN cord-015365-iqdi99pd 437 26 a a DT cord-015365-iqdi99pd 437 27 3-months 3-months CD cord-015365-iqdi99pd 437 28 follow follow NN cord-015365-iqdi99pd 437 29 - - HYPH cord-015365-iqdi99pd 437 30 up up NN cord-015365-iqdi99pd 437 31 . . . cord-015365-iqdi99pd 438 1 We -PRON- PRP cord-015365-iqdi99pd 438 2 included include VBD cord-015365-iqdi99pd 438 3 KTRs ktr NNS cord-015365-iqdi99pd 438 4 at at IN cord-015365-iqdi99pd 438 5 least least RBS cord-015365-iqdi99pd 438 6 12 12 CD cord-015365-iqdi99pd 438 7 months month NNS cord-015365-iqdi99pd 438 8 post post NN cord-015365-iqdi99pd 438 9 - - NN cord-015365-iqdi99pd 438 10 transplantation transplantation NN cord-015365-iqdi99pd 438 11 with with IN cord-015365-iqdi99pd 438 12 stable stable JJ cord-015365-iqdi99pd 438 13 renal renal JJ cord-015365-iqdi99pd 438 14 graft graft NN cord-015365-iqdi99pd 438 15 function function NN cord-015365-iqdi99pd 438 16 for for IN cord-015365-iqdi99pd 438 17 at at RB cord-015365-iqdi99pd 438 18 least least JJS cord-015365-iqdi99pd 438 19 3 3 CD cord-015365-iqdi99pd 438 20 months month NNS cord-015365-iqdi99pd 438 21 . . . cord-015365-iqdi99pd 439 1 The the DT cord-015365-iqdi99pd 439 2 maintenance maintenance NN cord-015365-iqdi99pd 439 3 treatment treatment NN cord-015365-iqdi99pd 439 4 consisted consist VBD cord-015365-iqdi99pd 439 5 of of IN cord-015365-iqdi99pd 439 6 MMF MMF NNP cord-015365-iqdi99pd 439 7 in in IN cord-015365-iqdi99pd 439 8 combination combination NN cord-015365-iqdi99pd 439 9 with with IN cord-015365-iqdi99pd 439 10 tacrolimus tacrolimus NN cord-015365-iqdi99pd 439 11 with with IN cord-015365-iqdi99pd 439 12 or or CC cord-015365-iqdi99pd 439 13 without without IN cord-015365-iqdi99pd 439 14 steroids steroid NNS cord-015365-iqdi99pd 439 15 . . . cord-015365-iqdi99pd 440 1 At at IN cord-015365-iqdi99pd 440 2 the the DT cord-015365-iqdi99pd 440 3 end end NN cord-015365-iqdi99pd 440 4 of of IN cord-015365-iqdi99pd 440 5 the the DT cord-015365-iqdi99pd 440 6 two two CD cord-015365-iqdi99pd 440 7 treatment treatment NN cord-015365-iqdi99pd 440 8 periods period NNS cord-015365-iqdi99pd 440 9 6-hour 6-hour CD cord-015365-iqdi99pd 440 10 or or CC cord-015365-iqdi99pd 440 11 12-hour 12-hour CD cord-015365-iqdi99pd 440 12 pharmacokinetic pharmacokinetic JJ cord-015365-iqdi99pd 440 13 studies study NNS cord-015365-iqdi99pd 440 14 of of IN cord-015365-iqdi99pd 440 15 mycophenolic mycophenolic NNP cord-015365-iqdi99pd 440 16 acid acid NNP cord-015365-iqdi99pd 440 17 ( ( -LRB- cord-015365-iqdi99pd 440 18 MPA MPA NNP cord-015365-iqdi99pd 440 19 ) ) -RRB- cord-015365-iqdi99pd 440 20 were be VBD cord-015365-iqdi99pd 440 21 performed perform VBN cord-015365-iqdi99pd 440 22 . . . cord-015365-iqdi99pd 441 1 Results result NNS cord-015365-iqdi99pd 441 2 ( ( -LRB- cord-015365-iqdi99pd 441 3 0 0 CD cord-015365-iqdi99pd 441 4 - - HYPH cord-015365-iqdi99pd 441 5 6h 6h CD cord-015365-iqdi99pd 441 6 ) ) -RRB- cord-015365-iqdi99pd 441 7 , , , cord-015365-iqdi99pd 441 8 and and CC cord-015365-iqdi99pd 441 9 Cmin Cmin NNP cord-015365-iqdi99pd 441 10 of of IN cord-015365-iqdi99pd 441 11 MPA MPA NNP cord-015365-iqdi99pd 441 12 were be VBD cord-015365-iqdi99pd 441 13 within within IN cord-015365-iqdi99pd 441 14 the the DT cord-015365-iqdi99pd 441 15 bioequivalence bioequivalence NN cord-015365-iqdi99pd 441 16 margins margin NNS cord-015365-iqdi99pd 441 17 and and CC cord-015365-iqdi99pd 441 18 Cmax Cmax NNP cord-015365-iqdi99pd 441 19 was be VBD cord-015365-iqdi99pd 441 20 marginally marginally RB cord-015365-iqdi99pd 441 21 outside outside RB cord-015365-iqdi99pd 441 22 of of IN cord-015365-iqdi99pd 441 23 these these DT cord-015365-iqdi99pd 441 24 margins margin NNS cord-015365-iqdi99pd 441 25 in in IN cord-015365-iqdi99pd 441 26 this this DT cord-015365-iqdi99pd 441 27 set set NN cord-015365-iqdi99pd 441 28 of of IN cord-015365-iqdi99pd 441 29 patients patient NNS cord-015365-iqdi99pd 441 30 . . . cord-015365-iqdi99pd 442 1 The the DT cord-015365-iqdi99pd 442 2 numbers number NNS cord-015365-iqdi99pd 442 3 and and CC cord-015365-iqdi99pd 442 4 types type NNS cord-015365-iqdi99pd 442 5 of of IN cord-015365-iqdi99pd 442 6 adverse adverse JJ cord-015365-iqdi99pd 442 7 events event NNS cord-015365-iqdi99pd 442 8 were be VBD cord-015365-iqdi99pd 442 9 not not RB cord-015365-iqdi99pd 442 10 different different JJ cord-015365-iqdi99pd 442 11 between between IN cord-015365-iqdi99pd 442 12 the the DT cord-015365-iqdi99pd 442 13 two two CD cord-015365-iqdi99pd 442 14 treatments treatment NNS cord-015365-iqdi99pd 442 15 . . . cord-015365-iqdi99pd 443 1 Conclusions conclusion NNS cord-015365-iqdi99pd 443 2 . . . cord-015365-iqdi99pd 444 1 The the DT cord-015365-iqdi99pd 444 2 steady steady JJ cord-015365-iqdi99pd 444 3 state state NN cord-015365-iqdi99pd 444 4 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 444 5 of of IN cord-015365-iqdi99pd 444 6 MPA MPA NNP cord-015365-iqdi99pd 444 7 as as RB cord-015365-iqdi99pd 444 8 well well RB cord-015365-iqdi99pd 444 9 as as IN cord-015365-iqdi99pd 444 10 adverse adverse JJ cord-015365-iqdi99pd 444 11 events event NNS cord-015365-iqdi99pd 444 12 are be VBP cord-015365-iqdi99pd 444 13 comparable comparable JJ cord-015365-iqdi99pd 444 14 for for IN cord-015365-iqdi99pd 444 15 Myfenax Myfenax NNP cord-015365-iqdi99pd 444 16 and and CC cord-015365-iqdi99pd 444 17 CellCept CellCept NNP cord-015365-iqdi99pd 444 18 in in IN cord-015365-iqdi99pd 444 19 Tacrolimus Tacrolimus NNP cord-015365-iqdi99pd 444 20 treated treat VBD cord-015365-iqdi99pd 444 21 stable stable JJ cord-015365-iqdi99pd 444 22 kidney kidney NN cord-015365-iqdi99pd 444 23 transplant transplant NN cord-015365-iqdi99pd 444 24 recipients recipient NNS cord-015365-iqdi99pd 444 25 . . . cord-015365-iqdi99pd 445 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 445 2 in in IN cord-015365-iqdi99pd 445 3 de de FW cord-015365-iqdi99pd 445 4 novo novo JJ cord-015365-iqdi99pd 445 5 kidney kidney NN cord-015365-iqdi99pd 445 6 transplant transplant NN cord-015365-iqdi99pd 445 7 recipients recipient NNS cord-015365-iqdi99pd 445 8 -10-year -10-year NN cord-015365-iqdi99pd 445 9 experience experience NN cord-015365-iqdi99pd 445 10 in in IN cord-015365-iqdi99pd 445 11 a a DT cord-015365-iqdi99pd 445 12 single single JJ cord-015365-iqdi99pd 445 13 center center NN cord-015365-iqdi99pd 445 14 Background background NN cord-015365-iqdi99pd 445 15 . . . cord-015365-iqdi99pd 446 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 446 2 is be VBZ cord-015365-iqdi99pd 446 3 a a DT cord-015365-iqdi99pd 446 4 co co JJ cord-015365-iqdi99pd 446 5 - - JJ cord-015365-iqdi99pd 446 6 stimulation stimulation NN cord-015365-iqdi99pd 446 7 blocker blocker NN cord-015365-iqdi99pd 446 8 which which WDT cord-015365-iqdi99pd 446 9 has have VBZ cord-015365-iqdi99pd 446 10 recently recently RB cord-015365-iqdi99pd 446 11 been be VBN cord-015365-iqdi99pd 446 12 approved approve VBN cord-015365-iqdi99pd 446 13 as as IN cord-015365-iqdi99pd 446 14 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 446 15 therapy therapy NN cord-015365-iqdi99pd 446 16 in in IN cord-015365-iqdi99pd 446 17 renal renal JJ cord-015365-iqdi99pd 446 18 transplant transplant NN cord-015365-iqdi99pd 446 19 recipients recipient NNS cord-015365-iqdi99pd 446 20 . . . cord-015365-iqdi99pd 447 1 Here here RB cord-015365-iqdi99pd 447 2 we -PRON- PRP cord-015365-iqdi99pd 447 3 assess assess VBP cord-015365-iqdi99pd 447 4 the the DT cord-015365-iqdi99pd 447 5 outcome outcome NN cord-015365-iqdi99pd 447 6 of of IN cord-015365-iqdi99pd 447 7 patients patient NNS cord-015365-iqdi99pd 447 8 that that WDT cord-015365-iqdi99pd 447 9 have have VBP cord-015365-iqdi99pd 447 10 been be VBN cord-015365-iqdi99pd 447 11 treated treat VBN cord-015365-iqdi99pd 447 12 with with IN cord-015365-iqdi99pd 447 13 belatacept belatacept NN cord-015365-iqdi99pd 447 14 for for IN cord-015365-iqdi99pd 447 15 10 10 CD cord-015365-iqdi99pd 447 16 years year NNS cord-015365-iqdi99pd 447 17 after after IN cord-015365-iqdi99pd 447 18 kidney kidney NN cord-015365-iqdi99pd 447 19 transplantation transplantation NN cord-015365-iqdi99pd 447 20 . . . cord-015365-iqdi99pd 448 1 Methods method NNS cord-015365-iqdi99pd 448 2 . . . cord-015365-iqdi99pd 449 1 In in IN cord-015365-iqdi99pd 449 2 our -PRON- PRP$ cord-015365-iqdi99pd 449 3 center center NN cord-015365-iqdi99pd 449 4 , , , cord-015365-iqdi99pd 449 5 22 22 CD cord-015365-iqdi99pd 449 6 patients patient NNS cord-015365-iqdi99pd 449 7 were be VBD cord-015365-iqdi99pd 449 8 enrolled enrol VBN cord-015365-iqdi99pd 449 9 in in IN cord-015365-iqdi99pd 449 10 the the DT cord-015365-iqdi99pd 449 11 phase phase NN cord-015365-iqdi99pd 449 12 II II NNP cord-015365-iqdi99pd 449 13 multi multi JJ cord-015365-iqdi99pd 449 14 - - JJ cord-015365-iqdi99pd 449 15 center center JJ cord-015365-iqdi99pd 449 16 belatacept belatacept NN cord-015365-iqdi99pd 449 17 trial trial NN cord-015365-iqdi99pd 449 18 that that WDT cord-015365-iqdi99pd 449 19 started start VBD cord-015365-iqdi99pd 449 20 in in IN cord-015365-iqdi99pd 449 21 2001 2001 CD cord-015365-iqdi99pd 449 22 . . . cord-015365-iqdi99pd 450 1 Patients patient NNS cord-015365-iqdi99pd 450 2 were be VBD cord-015365-iqdi99pd 450 3 randomly randomly RB cord-015365-iqdi99pd 450 4 assigned assign VBN cord-015365-iqdi99pd 450 5 to to IN cord-015365-iqdi99pd 450 6 belatacept-(n belatacept-(n NNP cord-015365-iqdi99pd 450 7 ¼ ¼ NNP cord-015365-iqdi99pd 450 8 14 14 CD cord-015365-iqdi99pd 450 9 ) ) -RRB- cord-015365-iqdi99pd 450 10 or or CC cord-015365-iqdi99pd 450 11 CyA-(n CyA-(n NNP cord-015365-iqdi99pd 450 12 ¼ ¼ NNP cord-015365-iqdi99pd 450 13 8) 8) NNP cord-015365-iqdi99pd 450 14 based base VBN cord-015365-iqdi99pd 450 15 immunosuppression immunosuppression NN cord-015365-iqdi99pd 450 16 ( ( -LRB- cord-015365-iqdi99pd 450 17 all all DT cord-015365-iqdi99pd 450 18 patients patient NNS cord-015365-iqdi99pd 450 19 received receive VBD cord-015365-iqdi99pd 450 20 basiliximab basiliximab NNS cord-015365-iqdi99pd 450 21 , , , cord-015365-iqdi99pd 450 22 MMF mmf NN cord-015365-iqdi99pd 450 23 and and CC cord-015365-iqdi99pd 450 24 steroids steroid NNS cord-015365-iqdi99pd 450 25 ) ) -RRB- cord-015365-iqdi99pd 450 26 . . . cord-015365-iqdi99pd 451 1 In in IN cord-015365-iqdi99pd 451 2 this this DT cord-015365-iqdi99pd 451 3 retrospective retrospective JJ cord-015365-iqdi99pd 451 4 analysis analysis NN cord-015365-iqdi99pd 451 5 we -PRON- PRP cord-015365-iqdi99pd 451 6 report report VBP cord-015365-iqdi99pd 451 7 the the DT cord-015365-iqdi99pd 451 8 outcome outcome NN cord-015365-iqdi99pd 451 9 of of IN cord-015365-iqdi99pd 451 10 the the DT cord-015365-iqdi99pd 451 11 belatacept belatacept NN cord-015365-iqdi99pd 451 12 group group NN cord-015365-iqdi99pd 451 13 as as IN cord-015365-iqdi99pd 451 14 of of IN cord-015365-iqdi99pd 451 15 June June NNP cord-015365-iqdi99pd 451 16 2011 2011 CD cord-015365-iqdi99pd 451 17 . . . cord-015365-iqdi99pd 452 1 Patient patient JJ cord-015365-iqdi99pd 452 2 and and CC cord-015365-iqdi99pd 452 3 graft graft NN cord-015365-iqdi99pd 452 4 survival survival NN cord-015365-iqdi99pd 452 5 , , , cord-015365-iqdi99pd 452 6 the the DT cord-015365-iqdi99pd 452 7 incidence incidence NN cord-015365-iqdi99pd 452 8 of of IN cord-015365-iqdi99pd 452 9 acute acute JJ cord-015365-iqdi99pd 452 10 rejection rejection NN cord-015365-iqdi99pd 452 11 , , , cord-015365-iqdi99pd 452 12 kidney kidney NN cord-015365-iqdi99pd 452 13 function function NN cord-015365-iqdi99pd 452 14 ( ( -LRB- cord-015365-iqdi99pd 452 15 calculated calculate VBN cord-015365-iqdi99pd 452 16 GFR GFR NNP cord-015365-iqdi99pd 452 17 ; ; : cord-015365-iqdi99pd 452 18 MDRD MDRD NNP cord-015365-iqdi99pd 452 19 [ [ -LRB- cord-015365-iqdi99pd 452 20 ml ml NN cord-015365-iqdi99pd 452 21 / / SYM cord-015365-iqdi99pd 452 22 min/1.73 min/1.73 JJ cord-015365-iqdi99pd 452 23 m m CD cord-015365-iqdi99pd 452 24 2 2 CD cord-015365-iqdi99pd 452 25 ] ] -RRB- cord-015365-iqdi99pd 452 26 ) ) -RRB- cord-015365-iqdi99pd 452 27 and and CC cord-015365-iqdi99pd 452 28 cardiovascular cardiovascular JJ cord-015365-iqdi99pd 452 29 risk risk NN cord-015365-iqdi99pd 452 30 profiles profile NNS cord-015365-iqdi99pd 452 31 ( ( -LRB- cord-015365-iqdi99pd 452 32 triglycerides triglyceride NNS cord-015365-iqdi99pd 452 33 and and CC cord-015365-iqdi99pd 452 34 cholesterol cholesterol NN cord-015365-iqdi99pd 452 35 ) ) -RRB- cord-015365-iqdi99pd 452 36 are be VBP cord-015365-iqdi99pd 452 37 presented present VBN cord-015365-iqdi99pd 452 38 . . . cord-015365-iqdi99pd 453 1 Results result NNS cord-015365-iqdi99pd 453 2 . . . cord-015365-iqdi99pd 454 1 At at IN cord-015365-iqdi99pd 454 2 an an DT cord-015365-iqdi99pd 454 3 average average NN cord-015365-iqdi99pd 454 4 of of IN cord-015365-iqdi99pd 454 5 9.2 9.2 CD cord-015365-iqdi99pd 454 6 ( ( -LRB- cord-015365-iqdi99pd 454 7 8.5 8.5 CD cord-015365-iqdi99pd 454 8 - - SYM cord-015365-iqdi99pd 454 9 10.1 10.1 CD cord-015365-iqdi99pd 454 10 ) ) -RRB- cord-015365-iqdi99pd 454 11 years year NNS cord-015365-iqdi99pd 454 12 after after IN cord-015365-iqdi99pd 454 13 kidney kidney NN cord-015365-iqdi99pd 454 14 transplantation transplantation NN cord-015365-iqdi99pd 454 15 9 9 CD cord-015365-iqdi99pd 454 16 out out IN cord-015365-iqdi99pd 454 17 of of IN cord-015365-iqdi99pd 454 18 14 14 CD cord-015365-iqdi99pd 454 19 belatacept belatacept NN cord-015365-iqdi99pd 454 20 ( ( -LRB- cord-015365-iqdi99pd 454 21 64 64 CD cord-015365-iqdi99pd 454 22 % % NN cord-015365-iqdi99pd 454 23 ) ) -RRB- cord-015365-iqdi99pd 454 24 patients patient NNS cord-015365-iqdi99pd 454 25 are be VBP cord-015365-iqdi99pd 454 26 still still RB cord-015365-iqdi99pd 454 27 on on IN cord-015365-iqdi99pd 454 28 therapy therapy NN cord-015365-iqdi99pd 454 29 . . . cord-015365-iqdi99pd 455 1 Five five CD cord-015365-iqdi99pd 455 2 patients patient NNS cord-015365-iqdi99pd 455 3 discontinued discontinue VBD cord-015365-iqdi99pd 455 4 the the DT cord-015365-iqdi99pd 455 5 study study NN cord-015365-iqdi99pd 455 6 : : : cord-015365-iqdi99pd 455 7 1 1 CD cord-015365-iqdi99pd 455 8 due due IN cord-015365-iqdi99pd 455 9 to to IN cord-015365-iqdi99pd 455 10 lack lack NN cord-015365-iqdi99pd 455 11 of of IN cord-015365-iqdi99pd 455 12 efficacy efficacy NN cord-015365-iqdi99pd 455 13 ( ( -LRB- cord-015365-iqdi99pd 455 14 ATG ATG NNP cord-015365-iqdi99pd 455 15 - - HYPH cord-015365-iqdi99pd 455 16 resistant resistant JJ cord-015365-iqdi99pd 455 17 rejection rejection NN cord-015365-iqdi99pd 455 18 ) ) -RRB- cord-015365-iqdi99pd 455 19 , , , cord-015365-iqdi99pd 455 20 1 1 CD cord-015365-iqdi99pd 455 21 due due JJ cord-015365-iqdi99pd 455 22 to to IN cord-015365-iqdi99pd 455 23 PTLD PTLD NNP cord-015365-iqdi99pd 455 24 , , , cord-015365-iqdi99pd 455 25 1 1 CD cord-015365-iqdi99pd 455 26 due due JJ cord-015365-iqdi99pd 455 27 to to IN cord-015365-iqdi99pd 455 28 pneumocystis pneumocystis NNP cord-015365-iqdi99pd 455 29 carinii carinii FW cord-015365-iqdi99pd 455 30 pneumonia pneumonia NN cord-015365-iqdi99pd 455 31 and and CC cord-015365-iqdi99pd 456 1 2 2 CD cord-015365-iqdi99pd 456 2 patients patient NNS cord-015365-iqdi99pd 456 3 withdrew withdraw VBD cord-015365-iqdi99pd 456 4 consent consent NN cord-015365-iqdi99pd 456 5 ( ( -LRB- cord-015365-iqdi99pd 456 6 1 1 CD cord-015365-iqdi99pd 456 7 and and CC cord-015365-iqdi99pd 456 8 3.5 3.5 CD cord-015365-iqdi99pd 456 9 years year NNS cord-015365-iqdi99pd 456 10 after after IN cord-015365-iqdi99pd 456 11 transplantation transplantation NN cord-015365-iqdi99pd 456 12 with with IN cord-015365-iqdi99pd 456 13 a a DT cord-015365-iqdi99pd 456 14 functioning function VBG cord-015365-iqdi99pd 456 15 graft graft NN cord-015365-iqdi99pd 456 16 ; ; : cord-015365-iqdi99pd 456 17 GFR gfr NN cord-015365-iqdi99pd 456 18 : : : cord-015365-iqdi99pd 456 19 65.4 65.4 CD cord-015365-iqdi99pd 456 20 and and CC cord-015365-iqdi99pd 456 21 46.05 46.05 CD cord-015365-iqdi99pd 456 22 ml ml NNS cord-015365-iqdi99pd 456 23 / / SYM cord-015365-iqdi99pd 456 24 min/1.73 min/1.73 VBN cord-015365-iqdi99pd 456 25 2 2 CD cord-015365-iqdi99pd 456 26 ) ) -RRB- cord-015365-iqdi99pd 456 27 . . . cord-015365-iqdi99pd 457 1 Three three CD cord-015365-iqdi99pd 457 2 patients patient NNS cord-015365-iqdi99pd 457 3 died die VBD cord-015365-iqdi99pd 457 4 : : : cord-015365-iqdi99pd 457 5 the the DT cord-015365-iqdi99pd 457 6 patient patient NN cord-015365-iqdi99pd 457 7 with with IN cord-015365-iqdi99pd 457 8 PTLD PTLD NNP cord-015365-iqdi99pd 457 9 and and CC cord-015365-iqdi99pd 457 10 the the DT cord-015365-iqdi99pd 457 11 patient patient NN cord-015365-iqdi99pd 457 12 with with IN cord-015365-iqdi99pd 457 13 pneumocystis pneumocystis NNP cord-015365-iqdi99pd 457 14 carinii carinii FW cord-015365-iqdi99pd 457 15 pneumonia pneumonia NN cord-015365-iqdi99pd 457 16 shortly shortly RB cord-015365-iqdi99pd 457 17 after after IN cord-015365-iqdi99pd 457 18 discontinuation discontinuation NN cord-015365-iqdi99pd 457 19 and and CC cord-015365-iqdi99pd 457 20 the the DT cord-015365-iqdi99pd 457 21 patient patient NN cord-015365-iqdi99pd 457 22 with with IN cord-015365-iqdi99pd 457 23 lack lack NN cord-015365-iqdi99pd 457 24 of of IN cord-015365-iqdi99pd 457 25 efficacy efficacy NN cord-015365-iqdi99pd 457 26 6 6 CD cord-015365-iqdi99pd 457 27 years year NNS cord-015365-iqdi99pd 457 28 later later RB cord-015365-iqdi99pd 457 29 due due JJ cord-015365-iqdi99pd 457 30 to to IN cord-015365-iqdi99pd 457 31 cardiac cardiac JJ cord-015365-iqdi99pd 457 32 arrest arrest NN cord-015365-iqdi99pd 457 33 . . . cord-015365-iqdi99pd 458 1 Two two CD cord-015365-iqdi99pd 458 2 patients patient NNS cord-015365-iqdi99pd 458 3 developed develop VBD cord-015365-iqdi99pd 458 4 biopsy biopsy NN cord-015365-iqdi99pd 458 5 - - HYPH cord-015365-iqdi99pd 458 6 proven prove VBN cord-015365-iqdi99pd 458 7 acute acute JJ cord-015365-iqdi99pd 458 8 rejection rejection NN cord-015365-iqdi99pd 458 9 ( ( -LRB- cord-015365-iqdi99pd 458 10 2/14 2/14 CD cord-015365-iqdi99pd 458 11 ; ; : cord-015365-iqdi99pd 458 12 14.3 14.3 CD cord-015365-iqdi99pd 458 13 % % NN cord-015365-iqdi99pd 458 14 ) ) -RRB- cord-015365-iqdi99pd 458 15 ( ( -LRB- cord-015365-iqdi99pd 458 16 BANFF BANFF NNP cord-015365-iqdi99pd 458 17 IIa IIa NNP cord-015365-iqdi99pd 458 18 , , , cord-015365-iqdi99pd 458 19 BANFF BANFF NNP cord-015365-iqdi99pd 458 20 IIb IIb NNP cord-015365-iqdi99pd 458 21 ) ) -RRB- cord-015365-iqdi99pd 458 22 . . . cord-015365-iqdi99pd 459 1 In in IN cord-015365-iqdi99pd 459 2 8 8 CD cord-015365-iqdi99pd 459 3 out out IN cord-015365-iqdi99pd 459 4 of of IN cord-015365-iqdi99pd 459 5 9 9 CD cord-015365-iqdi99pd 459 6 patients patient NNS cord-015365-iqdi99pd 459 7 kidney kidney NN cord-015365-iqdi99pd 459 8 function function NN cord-015365-iqdi99pd 459 9 remained remain VBD cord-015365-iqdi99pd 459 10 stable stable JJ cord-015365-iqdi99pd 459 11 over over IN cord-015365-iqdi99pd 459 12 time time NN cord-015365-iqdi99pd 459 13 : : : cord-015365-iqdi99pd 459 14 mean mean VB cord-015365-iqdi99pd 459 15 GFR GFR NNP cord-015365-iqdi99pd 459 16 12 12 CD cord-015365-iqdi99pd 459 17 months month NNS cord-015365-iqdi99pd 459 18 after after IN cord-015365-iqdi99pd 459 19 kidney kidney NN cord-015365-iqdi99pd 459 20 transplantation transplantation NN cord-015365-iqdi99pd 459 21 59.64 59.64 CD cord-015365-iqdi99pd 459 22 ( ( -LRB- cord-015365-iqdi99pd 459 23 SD SD NNP cord-015365-iqdi99pd 459 24 10.6 10.6 CD cord-015365-iqdi99pd 459 25 ) ) -RRB- cord-015365-iqdi99pd 459 26 , , , cord-015365-iqdi99pd 459 27 mean mean VBP cord-015365-iqdi99pd 459 28 eGFR egfr NN cord-015365-iqdi99pd 460 1 at at IN cord-015365-iqdi99pd 460 2 the the DT cord-015365-iqdi99pd 460 3 time time NN cord-015365-iqdi99pd 460 4 of of IN cord-015365-iqdi99pd 460 5 the the DT cord-015365-iqdi99pd 460 6 last last JJ cord-015365-iqdi99pd 460 7 visit visit NN cord-015365-iqdi99pd 460 8 : : : cord-015365-iqdi99pd 460 9 59.32 59.32 CD cord-015365-iqdi99pd 460 10 ( ( -LRB- cord-015365-iqdi99pd 460 11 SD SD NNP cord-015365-iqdi99pd 460 12 11.2 11.2 CD cord-015365-iqdi99pd 460 13 ) ) -RRB- cord-015365-iqdi99pd 460 14 . . . cord-015365-iqdi99pd 461 1 One one CD cord-015365-iqdi99pd 461 2 patient patient NN cord-015365-iqdi99pd 461 3 had have VBD cord-015365-iqdi99pd 461 4 an an DT cord-015365-iqdi99pd 461 5 impaired impaired JJ cord-015365-iqdi99pd 461 6 kidney kidney NN cord-015365-iqdi99pd 461 7 function function NN cord-015365-iqdi99pd 461 8 with with IN cord-015365-iqdi99pd 461 9 a a DT cord-015365-iqdi99pd 461 10 GFR GFR NNP cord-015365-iqdi99pd 461 11 of of IN cord-015365-iqdi99pd 461 12 45.03 45.03 CD cord-015365-iqdi99pd 461 13 at at IN cord-015365-iqdi99pd 461 14 the the DT cord-015365-iqdi99pd 461 15 last last JJ cord-015365-iqdi99pd 461 16 visit visit NN cord-015365-iqdi99pd 461 17 ( ( -LRB- cord-015365-iqdi99pd 461 18 GFR GFR NNP cord-015365-iqdi99pd 461 19 at at IN cord-015365-iqdi99pd 461 20 month month NN cord-015365-iqdi99pd 461 21 12 12 CD cord-015365-iqdi99pd 461 22 : : SYM cord-015365-iqdi99pd 461 23 68 68 CD cord-015365-iqdi99pd 461 24 ) ) -RRB- cord-015365-iqdi99pd 461 25 . . . cord-015365-iqdi99pd 462 1 Mean mean JJ cord-015365-iqdi99pd 462 2 serum serum NN cord-015365-iqdi99pd 462 3 triglycerides triglyceride NNS cord-015365-iqdi99pd 462 4 and and CC cord-015365-iqdi99pd 462 5 cholesterol cholesterol NN cord-015365-iqdi99pd 462 6 at at IN cord-015365-iqdi99pd 462 7 12 12 CD cord-015365-iqdi99pd 462 8 months month NNS cord-015365-iqdi99pd 462 9 after after IN cord-015365-iqdi99pd 462 10 transplantation transplantation NN cord-015365-iqdi99pd 462 11 were be VBD cord-015365-iqdi99pd 462 12 167 167 CD cord-015365-iqdi99pd 462 13 ( ( -LRB- cord-015365-iqdi99pd 462 14 SD SD NNP cord-015365-iqdi99pd 462 15 70 70 CD cord-015365-iqdi99pd 462 16 ) ) -RRB- cord-015365-iqdi99pd 462 17 and and CC cord-015365-iqdi99pd 462 18 207 207 CD cord-015365-iqdi99pd 462 19 ( ( -LRB- cord-015365-iqdi99pd 462 20 SD SD NNP cord-015365-iqdi99pd 462 21 34 34 CD cord-015365-iqdi99pd 462 22 ) ) -RRB- cord-015365-iqdi99pd 462 23 respectively respectively RB cord-015365-iqdi99pd 462 24 , , , cord-015365-iqdi99pd 462 25 and and CC cord-015365-iqdi99pd 462 26 changed change VBD cord-015365-iqdi99pd 462 27 little little JJ cord-015365-iqdi99pd 462 28 over over IN cord-015365-iqdi99pd 462 29 time time NN cord-015365-iqdi99pd 462 30 ( ( -LRB- cord-015365-iqdi99pd 462 31 mean mean VB cord-015365-iqdi99pd 462 32 triglycerides triglyceride NNS cord-015365-iqdi99pd 462 33 : : : cord-015365-iqdi99pd 462 34 159 159 CD cord-015365-iqdi99pd 462 35 ( ( -LRB- cord-015365-iqdi99pd 462 36 SD SD NNP cord-015365-iqdi99pd 462 37 44 44 CD cord-015365-iqdi99pd 462 38 ) ) -RRB- cord-015365-iqdi99pd 462 39 and and CC cord-015365-iqdi99pd 462 40 cholesterol cholesterol NN cord-015365-iqdi99pd 462 41 : : : cord-015365-iqdi99pd 462 42 201 201 CD cord-015365-iqdi99pd 462 43 ( ( -LRB- cord-015365-iqdi99pd 462 44 SD SD NNP cord-015365-iqdi99pd 462 45 44 44 CD cord-015365-iqdi99pd 462 46 ) ) -RRB- cord-015365-iqdi99pd 462 47 at at IN cord-015365-iqdi99pd 462 48 the the DT cord-015365-iqdi99pd 462 49 last last JJ cord-015365-iqdi99pd 462 50 visit visit NN cord-015365-iqdi99pd 462 51 ) ) -RRB- cord-015365-iqdi99pd 462 52 . . . cord-015365-iqdi99pd 463 1 Conclusions conclusion NNS cord-015365-iqdi99pd 463 2 . . . cord-015365-iqdi99pd 464 1 In in IN cord-015365-iqdi99pd 464 2 this this DT cord-015365-iqdi99pd 464 3 selected selected JJ cord-015365-iqdi99pd 464 4 group group NN cord-015365-iqdi99pd 464 5 of of IN cord-015365-iqdi99pd 464 6 patients patient NNS cord-015365-iqdi99pd 464 7 enrolled enrol VBN cord-015365-iqdi99pd 464 8 in in IN cord-015365-iqdi99pd 464 9 a a DT cord-015365-iqdi99pd 464 10 phase phase NN cord-015365-iqdi99pd 464 11 II II NNP cord-015365-iqdi99pd 464 12 trial trial NN cord-015365-iqdi99pd 464 13 , , , cord-015365-iqdi99pd 464 14 continuous continuous JJ cord-015365-iqdi99pd 464 15 use use NN cord-015365-iqdi99pd 464 16 of of IN cord-015365-iqdi99pd 464 17 belatacept belatacept NN cord-015365-iqdi99pd 464 18 therapy therapy NN cord-015365-iqdi99pd 464 19 for for IN cord-015365-iqdi99pd 464 20 10 10 CD cord-015365-iqdi99pd 464 21 years year NNS cord-015365-iqdi99pd 464 22 is be VBZ cord-015365-iqdi99pd 464 23 associated associate VBN cord-015365-iqdi99pd 464 24 with with IN cord-015365-iqdi99pd 464 25 stable stable JJ cord-015365-iqdi99pd 464 26 long long JJ cord-015365-iqdi99pd 464 27 - - HYPH cord-015365-iqdi99pd 464 28 term term NN cord-015365-iqdi99pd 464 29 graft graft NN cord-015365-iqdi99pd 464 30 function function NN cord-015365-iqdi99pd 464 31 in in IN cord-015365-iqdi99pd 464 32 a a DT cord-015365-iqdi99pd 464 33 high high JJ cord-015365-iqdi99pd 464 34 percentage percentage NN cord-015365-iqdi99pd 464 35 of of IN cord-015365-iqdi99pd 464 36 patients patient NNS cord-015365-iqdi99pd 464 37 . . . cord-015365-iqdi99pd 465 1 The the DT cord-015365-iqdi99pd 465 2 Innsbruck Innsbruck NNP cord-015365-iqdi99pd 465 3 Hand Hand NNP cord-015365-iqdi99pd 465 4 Transplant Transplant NNP cord-015365-iqdi99pd 465 5 Program Program NNP cord-015365-iqdi99pd 465 6 : : : cord-015365-iqdi99pd 465 7 update update VB cord-015365-iqdi99pd 465 8 at at IN cord-015365-iqdi99pd 465 9 11 11 CD cord-015365-iqdi99pd 465 10 years year NNS cord-015365-iqdi99pd 465 11 after after IN cord-015365-iqdi99pd 465 12 the the DT cord-015365-iqdi99pd 465 13 first first JJ cord-015365-iqdi99pd 465 14 transplant transplant NN cord-015365-iqdi99pd 465 15 Background background NN cord-015365-iqdi99pd 465 16 . . . cord-015365-iqdi99pd 466 1 We -PRON- PRP cord-015365-iqdi99pd 466 2 describe describe VBP cord-015365-iqdi99pd 466 3 here here RB cord-015365-iqdi99pd 466 4 the the DT cord-015365-iqdi99pd 466 5 outcome outcome NN cord-015365-iqdi99pd 466 6 after after IN cord-015365-iqdi99pd 466 7 two two CD cord-015365-iqdi99pd 466 8 bilateral bilateral JJ cord-015365-iqdi99pd 466 9 hand hand NN cord-015365-iqdi99pd 466 10 , , , cord-015365-iqdi99pd 466 11 one one CD cord-015365-iqdi99pd 466 12 bilateral bilateral JJ cord-015365-iqdi99pd 466 13 forearm forearm NN cord-015365-iqdi99pd 466 14 and and CC cord-015365-iqdi99pd 466 15 one one CD cord-015365-iqdi99pd 466 16 unilateral unilateral JJ cord-015365-iqdi99pd 466 17 hand hand NN cord-015365-iqdi99pd 466 18 transplantation transplantation NN cord-015365-iqdi99pd 466 19 at at IN cord-015365-iqdi99pd 466 20 11/8/5 11/8/5 CD cord-015365-iqdi99pd 466 21 and and CC cord-015365-iqdi99pd 466 22 2 2 CD cord-015365-iqdi99pd 466 23 years year NNS cord-015365-iqdi99pd 466 24 after after IN cord-015365-iqdi99pd 466 25 transplantation transplantation NN cord-015365-iqdi99pd 466 26 . . . cord-015365-iqdi99pd 467 1 Methods method NNS cord-015365-iqdi99pd 467 2 . . . cord-015365-iqdi99pd 468 1 Four four CD cord-015365-iqdi99pd 468 2 patients patient NNS cord-015365-iqdi99pd 468 3 received receive VBD cord-015365-iqdi99pd 468 4 a a DT cord-015365-iqdi99pd 468 5 bilateral bilateral JJ cord-015365-iqdi99pd 468 6 hand hand NN cord-015365-iqdi99pd 468 7 ( ( -LRB- cord-015365-iqdi99pd 468 8 n n NN cord-015365-iqdi99pd 468 9 ¼ ¼ NNP cord-015365-iqdi99pd 468 10 2 2 CD cord-015365-iqdi99pd 468 11 ) ) -RRB- cord-015365-iqdi99pd 468 12 , , , cord-015365-iqdi99pd 468 13 a a DT cord-015365-iqdi99pd 468 14 bilateral bilateral JJ cord-015365-iqdi99pd 468 15 forearm forearm NN cord-015365-iqdi99pd 468 16 ( ( -LRB- cord-015365-iqdi99pd 468 17 n n NN cord-015365-iqdi99pd 468 18 ¼ ¼ NNP cord-015365-iqdi99pd 468 19 1 1 CD cord-015365-iqdi99pd 468 20 ) ) -RRB- cord-015365-iqdi99pd 468 21 or or CC cord-015365-iqdi99pd 468 22 a a DT cord-015365-iqdi99pd 468 23 unilateral unilateral JJ cord-015365-iqdi99pd 468 24 hand hand NN cord-015365-iqdi99pd 468 25 transplant transplant NN cord-015365-iqdi99pd 468 26 between between IN cord-015365-iqdi99pd 468 27 March March NNP cord-015365-iqdi99pd 468 28 2000 2000 CD cord-015365-iqdi99pd 468 29 and and CC cord-015365-iqdi99pd 468 30 July July NNP cord-015365-iqdi99pd 468 31 2009 2009 CD cord-015365-iqdi99pd 468 32 . . . cord-015365-iqdi99pd 469 1 Induction induction NN cord-015365-iqdi99pd 469 2 therapy therapy NN cord-015365-iqdi99pd 469 3 with with IN cord-015365-iqdi99pd 469 4 ATG ATG NNP cord-015365-iqdi99pd 469 5 ( ( -LRB- cord-015365-iqdi99pd 469 6 n n NN cord-015365-iqdi99pd 469 7 ¼ ¼ NNP cord-015365-iqdi99pd 469 8 2 2 CD cord-015365-iqdi99pd 469 9 ) ) -RRB- cord-015365-iqdi99pd 469 10 or or CC cord-015365-iqdi99pd 469 11 alemtuzumab alemtuzumab NNP cord-015365-iqdi99pd 469 12 ( ( -LRB- cord-015365-iqdi99pd 469 13 n n NN cord-015365-iqdi99pd 469 14 ¼ ¼ NNP cord-015365-iqdi99pd 469 15 2 2 CD cord-015365-iqdi99pd 469 16 ) ) -RRB- cord-015365-iqdi99pd 469 17 was be VBD cord-015365-iqdi99pd 469 18 followed follow VBN cord-015365-iqdi99pd 469 19 by by IN cord-015365-iqdi99pd 469 20 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 469 21 , , , cord-015365-iqdi99pd 469 22 prednisolone prednisolone NN cord-015365-iqdi99pd 469 23 , , , cord-015365-iqdi99pd 470 1 MMF MMF NNP cord-015365-iqdi99pd 470 2 ( ( -LRB- cord-015365-iqdi99pd 470 3 n n NN cord-015365-iqdi99pd 470 4 ¼ ¼ NNP cord-015365-iqdi99pd 470 5 3 3 CD cord-015365-iqdi99pd 470 6 ) ) -RRB- cord-015365-iqdi99pd 470 7 or or CC cord-015365-iqdi99pd 470 8 tacrolimus tacrolimus NN cord-015365-iqdi99pd 470 9 and and CC cord-015365-iqdi99pd 470 10 MMF MMF NNP cord-015365-iqdi99pd 470 11 ( ( -LRB- cord-015365-iqdi99pd 470 12 n n NN cord-015365-iqdi99pd 470 13 ¼ ¼ NNP cord-015365-iqdi99pd 470 14 1 1 CD cord-015365-iqdi99pd 470 15 ) ) -RRB- cord-015365-iqdi99pd 470 16 maintenance maintenance NN cord-015365-iqdi99pd 470 17 IS be VBZ cord-015365-iqdi99pd 470 18 . . . cord-015365-iqdi99pd 471 1 Later later RB cord-015365-iqdi99pd 471 2 , , , cord-015365-iqdi99pd 471 3 sirolimus sirolimus NNP cord-015365-iqdi99pd 471 4 / / SYM cord-015365-iqdi99pd 471 5 everolimus everolimus NNP cord-015365-iqdi99pd 471 6 was be VBD cord-015365-iqdi99pd 471 7 added add VBN cord-015365-iqdi99pd 471 8 under under IN cord-015365-iqdi99pd 471 9 simultaneous simultaneous JJ cord-015365-iqdi99pd 471 10 withdrawal withdrawal NN cord-015365-iqdi99pd 471 11 ( ( -LRB- cord-015365-iqdi99pd 471 12 n n NN cord-015365-iqdi99pd 471 13 ¼ ¼ NNP cord-015365-iqdi99pd 471 14 2 2 CD cord-015365-iqdi99pd 471 15 ) ) -RRB- cord-015365-iqdi99pd 471 16 or or CC cord-015365-iqdi99pd 471 17 dose dose JJ cord-015365-iqdi99pd 471 18 reduction reduction NN cord-015365-iqdi99pd 471 19 ( ( -LRB- cord-015365-iqdi99pd 471 20 n n NN cord-015365-iqdi99pd 471 21 ¼ ¼ NNP cord-015365-iqdi99pd 471 22 1 1 CD cord-015365-iqdi99pd 471 23 ) ) -RRB- cord-015365-iqdi99pd 471 24 of of IN cord-015365-iqdi99pd 471 25 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 471 26 ( ( -LRB- cord-015365-iqdi99pd 471 27 n n NNP cord-015365-iqdi99pd 471 28 ¼ ¼ NNP cord-015365-iqdi99pd 471 29 1 1 CD cord-015365-iqdi99pd 471 30 ) ) -RRB- cord-015365-iqdi99pd 471 31 or or CC cord-015365-iqdi99pd 471 32 MMF MMF NNP cord-015365-iqdi99pd 471 33 ( ( -LRB- cord-015365-iqdi99pd 471 34 n n NN cord-015365-iqdi99pd 471 35 ¼ ¼ NNP cord-015365-iqdi99pd 471 36 1 1 CD cord-015365-iqdi99pd 471 37 ) ) -RRB- cord-015365-iqdi99pd 471 38 . . . cord-015365-iqdi99pd 472 1 Steroids steroid NNS cord-015365-iqdi99pd 472 2 were be VBD cord-015365-iqdi99pd 472 3 avoided avoid VBN cord-015365-iqdi99pd 472 4 in in IN cord-015365-iqdi99pd 472 5 one one CD cord-015365-iqdi99pd 472 6 and and CC cord-015365-iqdi99pd 472 7 withdrawn withdraw VBN cord-015365-iqdi99pd 472 8 in in IN cord-015365-iqdi99pd 472 9 two two CD cord-015365-iqdi99pd 472 10 patients patient NNS cord-015365-iqdi99pd 472 11 . . . cord-015365-iqdi99pd 473 1 Results result NNS cord-015365-iqdi99pd 473 2 . . . cord-015365-iqdi99pd 474 1 Range range NN cord-015365-iqdi99pd 474 2 of of IN cord-015365-iqdi99pd 474 3 motion motion NN cord-015365-iqdi99pd 474 4 reached reach VBD cord-015365-iqdi99pd 474 5 up up IN cord-015365-iqdi99pd 474 6 to to TO cord-015365-iqdi99pd 474 7 70 70 CD cord-015365-iqdi99pd 474 8 % % NN cord-015365-iqdi99pd 474 9 of of IN cord-015365-iqdi99pd 474 10 normal normal JJ cord-015365-iqdi99pd 474 11 with with IN cord-015365-iqdi99pd 474 12 a a DT cord-015365-iqdi99pd 474 13 grip grip NN cord-015365-iqdi99pd 474 14 strength strength NN cord-015365-iqdi99pd 474 15 of of IN cord-015365-iqdi99pd 474 16 2 2 CD cord-015365-iqdi99pd 474 17 - - SYM cord-015365-iqdi99pd 474 18 10 10 CD cord-015365-iqdi99pd 474 19 kg kg NNS cord-015365-iqdi99pd 474 20 . . . cord-015365-iqdi99pd 475 1 Hand hand NN cord-015365-iqdi99pd 475 2 function function NN cord-015365-iqdi99pd 475 3 correlated correlate VBN cord-015365-iqdi99pd 475 4 well well RB cord-015365-iqdi99pd 475 5 with with IN cord-015365-iqdi99pd 475 6 time time NN cord-015365-iqdi99pd 475 7 after after IN cord-015365-iqdi99pd 475 8 transplant transplant NN cord-015365-iqdi99pd 475 9 and and CC cord-015365-iqdi99pd 475 10 amputation amputation NN cord-015365-iqdi99pd 475 11 level level NN cord-015365-iqdi99pd 475 12 . . . cord-015365-iqdi99pd 476 1 Intrinsic intrinsic JJ cord-015365-iqdi99pd 476 2 hand hand NN cord-015365-iqdi99pd 476 3 muscle muscle NN cord-015365-iqdi99pd 476 4 function function NN cord-015365-iqdi99pd 476 5 recovery recovery NN cord-015365-iqdi99pd 476 6 and and CC cord-015365-iqdi99pd 476 7 discriminative discriminative JJ cord-015365-iqdi99pd 476 8 sensation sensation NN cord-015365-iqdi99pd 476 9 were be VBD cord-015365-iqdi99pd 476 10 observed observe VBN cord-015365-iqdi99pd 476 11 in in IN cord-015365-iqdi99pd 476 12 all all DT cord-015365-iqdi99pd 476 13 patients patient NNS cord-015365-iqdi99pd 476 14 . . . cord-015365-iqdi99pd 477 1 Complications complication NNS cord-015365-iqdi99pd 477 2 included include VBD cord-015365-iqdi99pd 477 3 CMV CMV NNP cord-015365-iqdi99pd 477 4 infection infection NN cord-015365-iqdi99pd 477 5 , , , cord-015365-iqdi99pd 477 6 fungal fungal JJ cord-015365-iqdi99pd 477 7 infection infection NN cord-015365-iqdi99pd 477 8 , , , cord-015365-iqdi99pd 477 9 hypertension hypertension NN cord-015365-iqdi99pd 477 10 , , , cord-015365-iqdi99pd 477 11 hyperglycemia hyperglycemia NN cord-015365-iqdi99pd 477 12 , , , cord-015365-iqdi99pd 477 13 transient transient JJ cord-015365-iqdi99pd 477 14 creatinine creatinine NN cord-015365-iqdi99pd 477 15 increase increase NN cord-015365-iqdi99pd 477 16 and and CC cord-015365-iqdi99pd 477 17 headache headache NN cord-015365-iqdi99pd 477 18 . . . cord-015365-iqdi99pd 478 1 Three three CD cord-015365-iqdi99pd 478 2 , , , cord-015365-iqdi99pd 478 3 six six CD cord-015365-iqdi99pd 478 4 , , , cord-015365-iqdi99pd 478 5 four four CD cord-015365-iqdi99pd 478 6 , , , cord-015365-iqdi99pd 478 7 and and CC cord-015365-iqdi99pd 479 1 one one CD cord-015365-iqdi99pd 479 2 rejection rejection NN cord-015365-iqdi99pd 479 3 episode episode NN cord-015365-iqdi99pd 479 4 were be VBD cord-015365-iqdi99pd 479 5 successfully successfully RB cord-015365-iqdi99pd 479 6 treated treat VBN cord-015365-iqdi99pd 479 7 with with IN cord-015365-iqdi99pd 479 8 steroids steroid NNS cord-015365-iqdi99pd 479 9 , , , cord-015365-iqdi99pd 479 10 anti anti JJ cord-015365-iqdi99pd 479 11 - - NNP cord-015365-iqdi99pd 479 12 CD25 cd25 JJ cord-015365-iqdi99pd 479 13 , , , cord-015365-iqdi99pd 479 14 anti anti JJ cord-015365-iqdi99pd 479 15 - - JJ cord-015365-iqdi99pd 479 16 CD52 cd52 JJ cord-015365-iqdi99pd 479 17 antibodies antibody NNS cord-015365-iqdi99pd 479 18 and/or and/or CC cord-015365-iqdi99pd 479 19 intensified intensify VBN cord-015365-iqdi99pd 479 20 maintenance maintenance NN cord-015365-iqdi99pd 479 21 IS be VBZ cord-015365-iqdi99pd 479 22 . . . cord-015365-iqdi99pd 480 1 Skin skin NN cord-015365-iqdi99pd 480 2 histology histology NN cord-015365-iqdi99pd 480 3 at at IN cord-015365-iqdi99pd 480 4 current current JJ cord-015365-iqdi99pd 480 5 shows show VBZ cord-015365-iqdi99pd 480 6 no no DT cord-015365-iqdi99pd 480 7 or or CC cord-015365-iqdi99pd 480 8 mild mild JJ cord-015365-iqdi99pd 480 9 perivascular perivascular JJ cord-015365-iqdi99pd 480 10 lymphocytic lymphocytic JJ cord-015365-iqdi99pd 480 11 infiltrates infiltrate VBZ cord-015365-iqdi99pd 480 12 without without IN cord-015365-iqdi99pd 480 13 signs sign NNS cord-015365-iqdi99pd 480 14 of of IN cord-015365-iqdi99pd 480 15 progression progression NN cord-015365-iqdi99pd 480 16 . . . cord-015365-iqdi99pd 481 1 Vessels vessel NNS cord-015365-iqdi99pd 481 2 are be VBP cord-015365-iqdi99pd 481 3 patent patent NN cord-015365-iqdi99pd 481 4 without without IN cord-015365-iqdi99pd 481 5 signs sign NNS cord-015365-iqdi99pd 481 6 for for IN cord-015365-iqdi99pd 481 7 luminal luminal JJ cord-015365-iqdi99pd 481 8 narrowing narrowing NN cord-015365-iqdi99pd 481 9 or or CC cord-015365-iqdi99pd 481 10 intimal intimal JJ cord-015365-iqdi99pd 481 11 proliferation proliferation NN cord-015365-iqdi99pd 481 12 . . . cord-015365-iqdi99pd 482 1 Conclusions conclusion NNS cord-015365-iqdi99pd 482 2 . . . cord-015365-iqdi99pd 483 1 The the DT cord-015365-iqdi99pd 483 2 overall overall JJ cord-015365-iqdi99pd 483 3 functional functional JJ cord-015365-iqdi99pd 483 4 outcome outcome NN cord-015365-iqdi99pd 483 5 and and CC cord-015365-iqdi99pd 483 6 patient patient JJ cord-015365-iqdi99pd 483 7 satisfaction satisfaction NN cord-015365-iqdi99pd 483 8 after after IN cord-015365-iqdi99pd 483 9 bilateral bilateral JJ cord-015365-iqdi99pd 483 10 hand hand NN cord-015365-iqdi99pd 483 11 , , , cord-015365-iqdi99pd 483 12 bilateral bilateral JJ cord-015365-iqdi99pd 483 13 forearm forearm NN cord-015365-iqdi99pd 483 14 and and CC cord-015365-iqdi99pd 483 15 unilateral unilateral JJ cord-015365-iqdi99pd 483 16 hand hand NN cord-015365-iqdi99pd 483 17 transplantation transplantation NN cord-015365-iqdi99pd 483 18 are be VBP cord-015365-iqdi99pd 483 19 highly highly RB cord-015365-iqdi99pd 483 20 encouraging encouraging JJ cord-015365-iqdi99pd 483 21 . . . cord-015365-iqdi99pd 484 1 All all DT cord-015365-iqdi99pd 484 2 patients patient NNS cord-015365-iqdi99pd 484 3 are be VBP cord-015365-iqdi99pd 484 4 now now RB cord-015365-iqdi99pd 484 5 free free JJ cord-015365-iqdi99pd 484 6 of of IN cord-015365-iqdi99pd 484 7 rejection rejection NN cord-015365-iqdi99pd 484 8 with with IN cord-015365-iqdi99pd 484 9 moderate moderate JJ cord-015365-iqdi99pd 484 10 levels level NNS cord-015365-iqdi99pd 484 11 of of IN cord-015365-iqdi99pd 484 12 IS is NN cord-015365-iqdi99pd 484 13 . . . cord-015365-iqdi99pd 485 1 Renal renal JJ cord-015365-iqdi99pd 485 2 function function NN cord-015365-iqdi99pd 485 3 efficacy efficacy NN cord-015365-iqdi99pd 485 4 measures measure NNS cord-015365-iqdi99pd 485 5 following follow VBG cord-015365-iqdi99pd 485 6 conversion conversion NN cord-015365-iqdi99pd 485 7 from from IN cord-015365-iqdi99pd 485 8 calcineurin calcineurin NNP cord-015365-iqdi99pd 485 9 inhibitors inhibitor NNS cord-015365-iqdi99pd 485 10 to to TO cord-015365-iqdi99pd 485 11 sirolimus sirolimus VB cord-015365-iqdi99pd 485 12 after after IN cord-015365-iqdi99pd 485 13 cardiac cardiac JJ cord-015365-iqdi99pd 485 14 transplantation transplantation NN cord-015365-iqdi99pd 485 15 in in IN cord-015365-iqdi99pd 485 16 patients patient NNS cord-015365-iqdi99pd 485 17 with with IN cord-015365-iqdi99pd 485 18 renal renal JJ cord-015365-iqdi99pd 485 19 insufficiency insufficiency NN cord-015365-iqdi99pd 485 20 Methods method NNS cord-015365-iqdi99pd 485 21 . . . cord-015365-iqdi99pd 486 1 This this DT cord-015365-iqdi99pd 486 2 was be VBD cord-015365-iqdi99pd 486 3 a a DT cord-015365-iqdi99pd 486 4 randomized randomized JJ cord-015365-iqdi99pd 486 5 ( ( -LRB- cord-015365-iqdi99pd 486 6 1:1 1:1 LS cord-015365-iqdi99pd 486 7 ) ) -RRB- cord-015365-iqdi99pd 486 8 , , , cord-015365-iqdi99pd 486 9 comparative comparative JJ cord-015365-iqdi99pd 486 10 , , , cord-015365-iqdi99pd 486 11 multinational multinational JJ cord-015365-iqdi99pd 486 12 , , , cord-015365-iqdi99pd 486 13 phase phase NN cord-015365-iqdi99pd 486 14 4 4 CD cord-015365-iqdi99pd 486 15 study study NN cord-015365-iqdi99pd 486 16 of of IN cord-015365-iqdi99pd 486 17 patients patient NNS cord-015365-iqdi99pd 486 18 1 1 CD cord-015365-iqdi99pd 486 19 - - SYM cord-015365-iqdi99pd 486 20 8 8 CD cord-015365-iqdi99pd 486 21 years year NNS cord-015365-iqdi99pd 486 22 posttransplant posttransplant NN cord-015365-iqdi99pd 486 23 . . . cord-015365-iqdi99pd 487 1 Patients patient NNS cord-015365-iqdi99pd 487 2 on on IN cord-015365-iqdi99pd 487 3 CNI CNI NNP cord-015365-iqdi99pd 487 4 therapy therapy NN cord-015365-iqdi99pd 487 5 with with IN cord-015365-iqdi99pd 487 6 GFR GFR NNP cord-015365-iqdi99pd 487 7 40 40 CD cord-015365-iqdi99pd 487 8 - - SYM cord-015365-iqdi99pd 487 9 90 90 CD cord-015365-iqdi99pd 487 10 mL/ mL/ NNS cord-015365-iqdi99pd 488 1 min/1.73 min/1.73 NNP cord-015365-iqdi99pd 488 2 m m CD cord-015365-iqdi99pd 488 3 2 2 CD cord-015365-iqdi99pd 488 4 were be VBD cord-015365-iqdi99pd 488 5 eligible eligible JJ cord-015365-iqdi99pd 488 6 for for IN cord-015365-iqdi99pd 488 7 inclusion inclusion NN cord-015365-iqdi99pd 488 8 . . . cord-015365-iqdi99pd 489 1 Exclusion exclusion NN cord-015365-iqdi99pd 489 2 criteria criterion NNS cord-015365-iqdi99pd 489 3 included include VBD cord-015365-iqdi99pd 489 4 acute acute JJ cord-015365-iqdi99pd 489 5 rejection rejection NN cord-015365-iqdi99pd 489 6 ( ( -LRB- cord-015365-iqdi99pd 489 7 AR AR NNP cord-015365-iqdi99pd 489 8 ) ) -RRB- cord-015365-iqdi99pd 489 9 within within IN cord-015365-iqdi99pd 489 10 3 3 CD cord-015365-iqdi99pd 489 11 mos mos NN cord-015365-iqdi99pd 489 12 or or CC cord-015365-iqdi99pd 489 13 proteinuria proteinuria NN cord-015365-iqdi99pd 490 1 > > XX cord-015365-iqdi99pd 491 1 500 500 CD cord-015365-iqdi99pd 491 2 mg mg NNP cord-015365-iqdi99pd 491 3 / / SYM cord-015365-iqdi99pd 491 4 d d NN cord-015365-iqdi99pd 491 5 . . . cord-015365-iqdi99pd 492 1 Primary primary JJ cord-015365-iqdi99pd 492 2 end end NN cord-015365-iqdi99pd 492 3 point point NN cord-015365-iqdi99pd 492 4 was be VBD cord-015365-iqdi99pd 492 5 1-yr 1-yr CD cord-015365-iqdi99pd 492 6 change change NN cord-015365-iqdi99pd 492 7 from from IN cord-015365-iqdi99pd 492 8 baseline baseline NN cord-015365-iqdi99pd 492 9 in in IN cord-015365-iqdi99pd 492 10 creatinine creatinine NN cord-015365-iqdi99pd 492 11 clearance clearance NN cord-015365-iqdi99pd 492 12 ( ( -LRB- cord-015365-iqdi99pd 492 13 CLcr CLcr NNP cord-015365-iqdi99pd 492 14 ) ) -RRB- cord-015365-iqdi99pd 492 15 . . . cord-015365-iqdi99pd 493 1 Results result NNS cord-015365-iqdi99pd 493 2 . . . cord-015365-iqdi99pd 494 1 A a DT cord-015365-iqdi99pd 494 2 total total NN cord-015365-iqdi99pd 494 3 of of IN cord-015365-iqdi99pd 494 4 114 114 CD cord-015365-iqdi99pd 494 5 patients patient NNS cord-015365-iqdi99pd 494 6 were be VBD cord-015365-iqdi99pd 494 7 randomized randomize VBN cord-015365-iqdi99pd 494 8 and and CC cord-015365-iqdi99pd 494 9 treated treat VBN cord-015365-iqdi99pd 494 10 ( ( -LRB- cord-015365-iqdi99pd 494 11 SRL SRL NNP cord-015365-iqdi99pd 494 12 57 57 CD cord-015365-iqdi99pd 494 13 ; ; : cord-015365-iqdi99pd 494 14 CNI CNI NNP cord-015365-iqdi99pd 494 15 57 57 CD cord-015365-iqdi99pd 494 16 ) ) -RRB- cord-015365-iqdi99pd 494 17 ; ; : cord-015365-iqdi99pd 494 18 mean mean VB cord-015365-iqdi99pd 494 19 baseline baseline JJ cord-015365-iqdi99pd 494 20 GFR GFR NNP cord-015365-iqdi99pd 494 21 was be VBD cord-015365-iqdi99pd 494 22 $ $ $ cord-015365-iqdi99pd 494 23 57 57 CD cord-015365-iqdi99pd 494 24 mL/ mL/ NNS cord-015365-iqdi99pd 494 25 min/1.73 min/1.73 NNP cord-015365-iqdi99pd 494 26 m m CD cord-015365-iqdi99pd 494 27 2 2 CD cord-015365-iqdi99pd 494 28 . . . cord-015365-iqdi99pd 495 1 In in IN cord-015365-iqdi99pd 495 2 the the DT cord-015365-iqdi99pd 495 3 ITT ITT NNP cord-015365-iqdi99pd 495 4 LOCF LOCF NNP cord-015365-iqdi99pd 495 5 analysis analysis NN cord-015365-iqdi99pd 495 6 , , , cord-015365-iqdi99pd 495 7 1-yr 1-yr CD cord-015365-iqdi99pd 495 8 adjusted adjust VBN cord-015365-iqdi99pd 495 9 mean mean JJ cord-015365-iqdi99pd 495 10 change change NN cord-015365-iqdi99pd 495 11 from from IN cord-015365-iqdi99pd 495 12 baseline baseline NN cord-015365-iqdi99pd 495 13 in in IN cord-015365-iqdi99pd 495 14 CLcr CLcr NNP cord-015365-iqdi99pd 495 15 was be VBD cord-015365-iqdi99pd 495 16 þ þ NNP cord-015365-iqdi99pd 495 17 4.0 4.0 CD cord-015365-iqdi99pd 495 18 and and CC cord-015365-iqdi99pd 495 19 À1.2 À1.2 NNP cord-015365-iqdi99pd 495 20 mL mL NNP cord-015365-iqdi99pd 495 21 / / SYM cord-015365-iqdi99pd 495 22 min/ min/ NNP cord-015365-iqdi99pd 495 23 1.73 1.73 CD cord-015365-iqdi99pd 495 24 m m NN cord-015365-iqdi99pd 495 25 2 2 CD cord-015365-iqdi99pd 495 26 for for IN cord-015365-iqdi99pd 495 27 SRL SRL NNP cord-015365-iqdi99pd 495 28 vs. vs. IN cord-015365-iqdi99pd 495 29 CNI CNI NNP cord-015365-iqdi99pd 495 30 , , , cord-015365-iqdi99pd 495 31 respectively respectively RB cord-015365-iqdi99pd 495 32 ( ( -LRB- cord-015365-iqdi99pd 495 33 p p NN cord-015365-iqdi99pd 495 34 < < XX cord-015365-iqdi99pd 495 35 0.001 0.001 CD cord-015365-iqdi99pd 495 36 ) ) -RRB- cord-015365-iqdi99pd 495 37 ; ; : cord-015365-iqdi99pd 495 38 for for IN cord-015365-iqdi99pd 495 39 the the DT cord-015365-iqdi99pd 495 40 OT OT NNP cord-015365-iqdi99pd 495 41 analysis analysis NN cord-015365-iqdi99pd 495 42 , , , cord-015365-iqdi99pd 495 43 values value NNS cord-015365-iqdi99pd 495 44 were be VBD cord-015365-iqdi99pd 495 45 þ4.7 þ4.7 JJ cord-015365-iqdi99pd 495 46 and and CC cord-015365-iqdi99pd 495 47 À2.1 À2.1 NNP cord-015365-iqdi99pd 495 48 , , , cord-015365-iqdi99pd 495 49 respectively respectively RB cord-015365-iqdi99pd 495 50 ( ( -LRB- cord-015365-iqdi99pd 495 51 p p NN cord-015365-iqdi99pd 495 52 < < XX cord-015365-iqdi99pd 495 53 0.001 0.001 CD cord-015365-iqdi99pd 495 54 ) ) -RRB- cord-015365-iqdi99pd 495 55 . . . cord-015365-iqdi99pd 496 1 AR AR NNP cord-015365-iqdi99pd 496 2 rates rate NNS cord-015365-iqdi99pd 496 3 were be VBD cord-015365-iqdi99pd 496 4 numerically numerically RB cord-015365-iqdi99pd 496 5 higher high JJR cord-015365-iqdi99pd 496 6 in in IN cord-015365-iqdi99pd 496 7 the the DT cord-015365-iqdi99pd 496 8 SRL SRL NNP cord-015365-iqdi99pd 496 9 group group NN cord-015365-iqdi99pd 496 10 ; ; : cord-015365-iqdi99pd 496 11 there there EX cord-015365-iqdi99pd 496 12 was be VBD cord-015365-iqdi99pd 496 13 1 1 CD cord-015365-iqdi99pd 496 14 AR AR NNP cord-015365-iqdi99pd 496 15 with with IN cord-015365-iqdi99pd 496 16 hemodynamic hemodynamic JJ cord-015365-iqdi99pd 496 17 compromise compromise NN cord-015365-iqdi99pd 496 18 in in IN cord-015365-iqdi99pd 496 19 each each DT cord-015365-iqdi99pd 496 20 group group NN cord-015365-iqdi99pd 496 21 . . . cord-015365-iqdi99pd 497 1 A a DT cord-015365-iqdi99pd 497 2 significantly significantly RB cord-015365-iqdi99pd 497 3 higher high JJR cord-015365-iqdi99pd 497 4 ( ( -LRB- cord-015365-iqdi99pd 497 5 33.3 33.3 CD cord-015365-iqdi99pd 497 6 % % NN cord-015365-iqdi99pd 497 7 vs. vs. CC cord-015365-iqdi99pd 497 8 0 0 CD cord-015365-iqdi99pd 497 9 % % NN cord-015365-iqdi99pd 497 10 ; ; : cord-015365-iqdi99pd 497 11 p p NN cord-015365-iqdi99pd 497 12 < < XX cord-015365-iqdi99pd 497 13 0.001 0.001 CD cord-015365-iqdi99pd 497 14 ) ) -RRB- cord-015365-iqdi99pd 497 15 treatment treatment NN cord-015365-iqdi99pd 497 16 discontinuation discontinuation NN cord-015365-iqdi99pd 497 17 rate rate NN cord-015365-iqdi99pd 497 18 due due IN cord-015365-iqdi99pd 497 19 to to IN cord-015365-iqdi99pd 497 20 AEs AEs NNP cord-015365-iqdi99pd 497 21 was be VBD cord-015365-iqdi99pd 497 22 seen see VBN cord-015365-iqdi99pd 497 23 in in IN cord-015365-iqdi99pd 497 24 the the DT cord-015365-iqdi99pd 497 25 SRL SRL NNP cord-015365-iqdi99pd 497 26 group group NN cord-015365-iqdi99pd 497 27 . . . cord-015365-iqdi99pd 498 1 Most Most JJS cord-015365-iqdi99pd 498 2 common common JJ cord-015365-iqdi99pd 498 3 treatment treatment NN cord-015365-iqdi99pd 498 4 - - HYPH cord-015365-iqdi99pd 498 5 emergent emergent JJ cord-015365-iqdi99pd 498 6 AEs ae NNS cord-015365-iqdi99pd 498 7 that that WDT cord-015365-iqdi99pd 498 8 were be VBD cord-015365-iqdi99pd 498 9 significantly significantly RB cord-015365-iqdi99pd 498 10 higher high JJR cord-015365-iqdi99pd 498 11 in in IN cord-015365-iqdi99pd 498 12 the the DT cord-015365-iqdi99pd 498 13 SRL SRL NNP cord-015365-iqdi99pd 498 14 group group NN cord-015365-iqdi99pd 498 15 were be VBD cord-015365-iqdi99pd 498 16 diarrhea diarrhea JJ cord-015365-iqdi99pd 498 17 ( ( -LRB- cord-015365-iqdi99pd 498 18 28.1 28.1 CD cord-015365-iqdi99pd 498 19 % % NN cord-015365-iqdi99pd 498 20 ) ) -RRB- cord-015365-iqdi99pd 498 21 , , , cord-015365-iqdi99pd 498 22 rash rash JJ cord-015365-iqdi99pd 498 23 ( ( -LRB- cord-015365-iqdi99pd 498 24 28.1 28.1 CD cord-015365-iqdi99pd 498 25 % % NN cord-015365-iqdi99pd 498 26 ) ) -RRB- cord-015365-iqdi99pd 498 27 and and CC cord-015365-iqdi99pd 498 28 infections infection NNS cord-015365-iqdi99pd 498 29 ( ( -LRB- cord-015365-iqdi99pd 498 30 47.4 47.4 CD cord-015365-iqdi99pd 498 31 % % NN cord-015365-iqdi99pd 498 32 ) ) -RRB- cord-015365-iqdi99pd 498 33 . . . cord-015365-iqdi99pd 499 1 Conclusions conclusion NNS cord-015365-iqdi99pd 499 2 . . . cord-015365-iqdi99pd 500 1 Conversion conversion NN cord-015365-iqdi99pd 500 2 to to IN cord-015365-iqdi99pd 500 3 SRL SRL NNP cord-015365-iqdi99pd 500 4 from from IN cord-015365-iqdi99pd 500 5 CNI CNI NNP cord-015365-iqdi99pd 500 6 therapy therapy NN cord-015365-iqdi99pd 500 7 resulted result VBD cord-015365-iqdi99pd 500 8 in in IN cord-015365-iqdi99pd 500 9 improved improved JJ cord-015365-iqdi99pd 500 10 renal renal JJ cord-015365-iqdi99pd 500 11 function function NN cord-015365-iqdi99pd 500 12 in in IN cord-015365-iqdi99pd 500 13 cardiac cardiac JJ cord-015365-iqdi99pd 500 14 transplant transplant NN cord-015365-iqdi99pd 500 15 recipients recipient NNS cord-015365-iqdi99pd 500 16 with with IN cord-015365-iqdi99pd 500 17 renal renal JJ cord-015365-iqdi99pd 500 18 insufficiency insufficiency NN cord-015365-iqdi99pd 500 19 , , , cord-015365-iqdi99pd 500 20 but but CC cord-015365-iqdi99pd 500 21 was be VBD cord-015365-iqdi99pd 500 22 associated associate VBN cord-015365-iqdi99pd 500 23 with with IN cord-015365-iqdi99pd 500 24 an an DT cord-015365-iqdi99pd 500 25 attendant attendant NN cord-015365-iqdi99pd 500 26 AR AR NNP cord-015365-iqdi99pd 500 27 risk risk NN cord-015365-iqdi99pd 500 28 and and CC cord-015365-iqdi99pd 500 29 higher high JJR cord-015365-iqdi99pd 500 30 discontinuation discontinuation NN cord-015365-iqdi99pd 500 31 rate rate NN cord-015365-iqdi99pd 500 32 due due IN cord-015365-iqdi99pd 500 33 to to IN cord-015365-iqdi99pd 500 34 AEs AEs NNP cord-015365-iqdi99pd 500 35 . . . cord-015365-iqdi99pd 501 1 Background background NN cord-015365-iqdi99pd 501 2 . . . cord-015365-iqdi99pd 502 1 ATG ATG NNP cord-015365-iqdi99pd 502 2 - - HYPH cord-015365-iqdi99pd 502 3 induction induction NN cord-015365-iqdi99pd 502 4 therapy therapy NN cord-015365-iqdi99pd 502 5 after after IN cord-015365-iqdi99pd 502 6 heart heart NN cord-015365-iqdi99pd 502 7 transplantation transplantation NN cord-015365-iqdi99pd 502 8 is be VBZ cord-015365-iqdi99pd 502 9 still still RB cord-015365-iqdi99pd 502 10 controversial controversial JJ cord-015365-iqdi99pd 502 11 and and CC cord-015365-iqdi99pd 502 12 used use VBN cord-015365-iqdi99pd 502 13 only only RB cord-015365-iqdi99pd 502 14 by by IN cord-015365-iqdi99pd 502 15 less less JJR cord-015365-iqdi99pd 502 16 than than IN cord-015365-iqdi99pd 502 17 50 50 CD cord-015365-iqdi99pd 502 18 % % NN cord-015365-iqdi99pd 502 19 of of IN cord-015365-iqdi99pd 502 20 centers center NNS cord-015365-iqdi99pd 502 21 . . . cord-015365-iqdi99pd 503 1 Moreover moreover RB cord-015365-iqdi99pd 503 2 , , , cord-015365-iqdi99pd 503 3 there there EX cord-015365-iqdi99pd 503 4 exist exist VBP cord-015365-iqdi99pd 503 5 no no DT cord-015365-iqdi99pd 503 6 data datum NNS cord-015365-iqdi99pd 503 7 about about IN cord-015365-iqdi99pd 503 8 the the DT cord-015365-iqdi99pd 503 9 optimal optimal JJ cord-015365-iqdi99pd 503 10 dosage dosage NN cord-015365-iqdi99pd 503 11 of of IN cord-015365-iqdi99pd 503 12 ATG ATG NNP cord-015365-iqdi99pd 503 13 - - HYPH cord-015365-iqdi99pd 503 14 induction induction NN cord-015365-iqdi99pd 503 15 . . . cord-015365-iqdi99pd 504 1 The the DT cord-015365-iqdi99pd 504 2 aim aim NN cord-015365-iqdi99pd 504 3 of of IN cord-015365-iqdi99pd 504 4 this this DT cord-015365-iqdi99pd 504 5 study study NN cord-015365-iqdi99pd 504 6 is be VBZ cord-015365-iqdi99pd 504 7 to to TO cord-015365-iqdi99pd 504 8 compare compare VB cord-015365-iqdi99pd 504 9 different different JJ cord-015365-iqdi99pd 504 10 doses dose NNS cord-015365-iqdi99pd 504 11 of of IN cord-015365-iqdi99pd 504 12 ATG ATG NNP cord-015365-iqdi99pd 504 13 - - HYPH cord-015365-iqdi99pd 504 14 induction induction NN cord-015365-iqdi99pd 504 15 . . . cord-015365-iqdi99pd 505 1 Methods method NNS cord-015365-iqdi99pd 505 2 . . . cord-015365-iqdi99pd 506 1 Between between IN cord-015365-iqdi99pd 506 2 1996 1996 CD cord-015365-iqdi99pd 506 3 and and CC cord-015365-iqdi99pd 506 4 2009 2009 CD cord-015365-iqdi99pd 506 5 586 586 CD cord-015365-iqdi99pd 506 6 cardiac cardiac JJ cord-015365-iqdi99pd 506 7 transplants transplant NNS cord-015365-iqdi99pd 506 8 were be VBD cord-015365-iqdi99pd 506 9 performed perform VBN cord-015365-iqdi99pd 506 10 in in IN cord-015365-iqdi99pd 506 11 our -PRON- PRP$ cord-015365-iqdi99pd 506 12 center center NN cord-015365-iqdi99pd 506 13 . . . cord-015365-iqdi99pd 507 1 523 523 CD cord-015365-iqdi99pd 507 2 ( ( -LRB- cord-015365-iqdi99pd 507 3 89 89 CD cord-015365-iqdi99pd 507 4 % % NN cord-015365-iqdi99pd 507 5 ) ) -RRB- cord-015365-iqdi99pd 507 6 patients patient NNS cord-015365-iqdi99pd 507 7 with with IN cord-015365-iqdi99pd 507 8 full full JJ cord-015365-iqdi99pd 507 9 data data NN cord-015365-iqdi99pd 507 10 sets set NNS cord-015365-iqdi99pd 507 11 were be VBD cord-015365-iqdi99pd 507 12 included include VBN cord-015365-iqdi99pd 507 13 in in IN cord-015365-iqdi99pd 507 14 the the DT cord-015365-iqdi99pd 507 15 analysis analysis NN cord-015365-iqdi99pd 507 16 . . . cord-015365-iqdi99pd 508 1 The the DT cord-015365-iqdi99pd 508 2 median median JJ cord-015365-iqdi99pd 508 3 age age NN cord-015365-iqdi99pd 508 4 was be VBD cord-015365-iqdi99pd 508 5 56 56 CD cord-015365-iqdi99pd 508 6 years year NNS cord-015365-iqdi99pd 508 7 , , , cord-015365-iqdi99pd 508 8 21 21 CD cord-015365-iqdi99pd 508 9 % % NN cord-015365-iqdi99pd 508 10 ( ( -LRB- cord-015365-iqdi99pd 508 11 n n NN cord-015365-iqdi99pd 508 12 ¼ ¼ NNP cord-015365-iqdi99pd 508 13 112 112 CD cord-015365-iqdi99pd 508 14 ) ) -RRB- cord-015365-iqdi99pd 508 15 were be VBD cord-015365-iqdi99pd 508 16 female female JJ cord-015365-iqdi99pd 508 17 . . . cord-015365-iqdi99pd 509 1 The the DT cord-015365-iqdi99pd 509 2 median median JJ cord-015365-iqdi99pd 509 3 follow follow NN cord-015365-iqdi99pd 509 4 - - HYPH cord-015365-iqdi99pd 509 5 up up NN cord-015365-iqdi99pd 509 6 - - HYPH cord-015365-iqdi99pd 509 7 time time NN cord-015365-iqdi99pd 509 8 was be VBD cord-015365-iqdi99pd 509 9 98 98 CD cord-015365-iqdi99pd 509 10 months month NNS cord-015365-iqdi99pd 509 11 . . . cord-015365-iqdi99pd 510 1 Patients patient NNS cord-015365-iqdi99pd 510 2 were be VBD cord-015365-iqdi99pd 510 3 divided divide VBN cord-015365-iqdi99pd 510 4 into into IN cord-015365-iqdi99pd 510 5 3 3 CD cord-015365-iqdi99pd 510 6 different different JJ cord-015365-iqdi99pd 510 7 groups group NNS cord-015365-iqdi99pd 510 8 according accord VBG cord-015365-iqdi99pd 510 9 to to IN cord-015365-iqdi99pd 510 10 total total JJ cord-015365-iqdi99pd 510 11 ATG ATG NNP cord-015365-iqdi99pd 510 12 dose dose NN cord-015365-iqdi99pd 510 13 : : : cord-015365-iqdi99pd 510 14 Group Group NNP cord-015365-iqdi99pd 510 15 A A NNP cord-015365-iqdi99pd 510 16 : : : cord-015365-iqdi99pd 510 17 ¼ ¼ CD cord-015365-iqdi99pd 510 18 4.5 4.5 CD cord-015365-iqdi99pd 510 19 mg mg NNP cord-015365-iqdi99pd 510 20 / / SYM cord-015365-iqdi99pd 510 21 kg kg NNP cord-015365-iqdi99pd 510 22 vs. vs. IN cord-015365-iqdi99pd 510 23 Group Group NNP cord-015365-iqdi99pd 510 24 B B NNP cord-015365-iqdi99pd 510 25 : : : cord-015365-iqdi99pd 510 26 4.5 4.5 CD cord-015365-iqdi99pd 510 27 - - SYM cord-015365-iqdi99pd 510 28 7.5 7.5 CD cord-015365-iqdi99pd 510 29 mg/ mg/ NN cord-015365-iqdi99pd 510 30 kg kg NNP cord-015365-iqdi99pd 510 31 vs. vs. IN cord-015365-iqdi99pd 510 32 Group Group NNP cord-015365-iqdi99pd 510 33 C C NNP cord-015365-iqdi99pd 510 34 : : : cord-015365-iqdi99pd 510 35 > > XX cord-015365-iqdi99pd 510 36 7.5 7.5 CD cord-015365-iqdi99pd 510 37 mg mg NNP cord-015365-iqdi99pd 510 38 / / SYM cord-015365-iqdi99pd 510 39 kg kg NN cord-015365-iqdi99pd 510 40 . . . cord-015365-iqdi99pd 511 1 Survival survival NN cord-015365-iqdi99pd 511 2 , , , cord-015365-iqdi99pd 511 3 incidence incidence NN cord-015365-iqdi99pd 511 4 of of IN cord-015365-iqdi99pd 511 5 rejection rejection NN cord-015365-iqdi99pd 511 6 , , , cord-015365-iqdi99pd 511 7 infection infection NN cord-015365-iqdi99pd 511 8 , , , cord-015365-iqdi99pd 511 9 graft graft NN cord-015365-iqdi99pd 511 10 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 511 11 and and CC cord-015365-iqdi99pd 511 12 cancer cancer NN cord-015365-iqdi99pd 511 13 were be VBD cord-015365-iqdi99pd 511 14 compared compare VBN cord-015365-iqdi99pd 511 15 by by IN cord-015365-iqdi99pd 511 16 Kaplan Kaplan NNP cord-015365-iqdi99pd 511 17 - - HYPH cord-015365-iqdi99pd 511 18 Meier Meier NNP cord-015365-iqdi99pd 511 19 - - HYPH cord-015365-iqdi99pd 511 20 analyses analysis NNS cord-015365-iqdi99pd 511 21 ( ( -LRB- cord-015365-iqdi99pd 511 22 log log NN cord-015365-iqdi99pd 511 23 rank rank NN cord-015365-iqdi99pd 511 24 test test NN cord-015365-iqdi99pd 511 25 ) ) -RRB- cord-015365-iqdi99pd 511 26 . . . cord-015365-iqdi99pd 512 1 Results result NNS cord-015365-iqdi99pd 512 2 . . . cord-015365-iqdi99pd 513 1 There there EX cord-015365-iqdi99pd 513 2 was be VBD cord-015365-iqdi99pd 513 3 better well JJR cord-015365-iqdi99pd 513 4 early early JJ cord-015365-iqdi99pd 513 5 ( ( -LRB- cord-015365-iqdi99pd 513 6 12 12 CD cord-015365-iqdi99pd 513 7 m m NN cord-015365-iqdi99pd 513 8 ) ) -RRB- cord-015365-iqdi99pd 513 9 and and CC cord-015365-iqdi99pd 513 10 late late JJ cord-015365-iqdi99pd 513 11 ( ( -LRB- cord-015365-iqdi99pd 513 12 150 150 CD cord-015365-iqdi99pd 513 13 m m NN cord-015365-iqdi99pd 513 14 ) ) -RRB- cord-015365-iqdi99pd 513 15 survival survival NN cord-015365-iqdi99pd 513 16 in in IN cord-015365-iqdi99pd 513 17 Group Group NNP cord-015365-iqdi99pd 513 18 B B NNP cord-015365-iqdi99pd 513 19 ( ( -LRB- cord-015365-iqdi99pd 513 20 A a NN cord-015365-iqdi99pd 513 21 : : : cord-015365-iqdi99pd 513 22 80 80 CD cord-015365-iqdi99pd 513 23 % % NN cord-015365-iqdi99pd 513 24 , , , cord-015365-iqdi99pd 513 25 43 43 CD cord-015365-iqdi99pd 513 26 % % NN cord-015365-iqdi99pd 513 27 ; ; : cord-015365-iqdi99pd 513 28 B b NN cord-015365-iqdi99pd 513 29 : : : cord-015365-iqdi99pd 513 30 90 90 CD cord-015365-iqdi99pd 513 31 % % NN cord-015365-iqdi99pd 513 32 , , , cord-015365-iqdi99pd 513 33 65 65 CD cord-015365-iqdi99pd 513 34 % % NN cord-015365-iqdi99pd 513 35 ; ; : cord-015365-iqdi99pd 513 36 C c NN cord-015365-iqdi99pd 513 37 : : : cord-015365-iqdi99pd 513 38 88 88 CD cord-015365-iqdi99pd 513 39 % % NN cord-015365-iqdi99pd 513 40 , , , cord-015365-iqdi99pd 513 41 58 58 CD cord-015365-iqdi99pd 513 42 % % NN cord-015365-iqdi99pd 513 43 ; ; : cord-015365-iqdi99pd 513 44 p p NN cord-015365-iqdi99pd 513 45 ¼ ¼ NNP cord-015365-iqdi99pd 513 46 n.s n.s NNP cord-015365-iqdi99pd 513 47 . . NNP cord-015365-iqdi99pd 513 48 ) ) -RRB- cord-015365-iqdi99pd 513 49 , , , cord-015365-iqdi99pd 513 50 however however RB cord-015365-iqdi99pd 513 51 , , , cord-015365-iqdi99pd 513 52 the the DT cord-015365-iqdi99pd 513 53 difference difference NN cord-015365-iqdi99pd 513 54 was be VBD cord-015365-iqdi99pd 513 55 not not RB cord-015365-iqdi99pd 513 56 significant significant JJ cord-015365-iqdi99pd 513 57 . . . cord-015365-iqdi99pd 514 1 Freedom freedom NN cord-015365-iqdi99pd 514 2 from from IN cord-015365-iqdi99pd 514 3 treated treat VBN cord-015365-iqdi99pd 514 4 acute acute JJ cord-015365-iqdi99pd 514 5 rejection rejection NN cord-015365-iqdi99pd 514 6 was be VBD cord-015365-iqdi99pd 514 7 better well JJR cord-015365-iqdi99pd 514 8 in in IN cord-015365-iqdi99pd 514 9 group group NN cord-015365-iqdi99pd 514 10 B b NN cord-015365-iqdi99pd 514 11 ( ( -LRB- cord-015365-iqdi99pd 514 12 88 88 CD cord-015365-iqdi99pd 514 13 % % NN cord-015365-iqdi99pd 514 14 ) ) -RRB- cord-015365-iqdi99pd 514 15 compared compare VBN cord-015365-iqdi99pd 514 16 to to IN cord-015365-iqdi99pd 514 17 A a NN cord-015365-iqdi99pd 514 18 and and CC cord-015365-iqdi99pd 514 19 C C NNP cord-015365-iqdi99pd 514 20 ( ( -LRB- cord-015365-iqdi99pd 514 21 79 79 CD cord-015365-iqdi99pd 514 22 % % NN cord-015365-iqdi99pd 514 23 , , , cord-015365-iqdi99pd 514 24 80 80 CD cord-015365-iqdi99pd 514 25 % % NN cord-015365-iqdi99pd 514 26 , , , cord-015365-iqdi99pd 514 27 p p NN cord-015365-iqdi99pd 514 28 ¼ ¼ CD cord-015365-iqdi99pd 514 29 0.08 0.08 CD cord-015365-iqdi99pd 514 30 ) ) -RRB- cord-015365-iqdi99pd 514 31 . . . cord-015365-iqdi99pd 515 1 Signs sign NNS cord-015365-iqdi99pd 515 2 of of IN cord-015365-iqdi99pd 515 3 histological histological JJ cord-015365-iqdi99pd 515 4 rejection rejection NN cord-015365-iqdi99pd 515 5 were be VBD cord-015365-iqdi99pd 515 6 significantly significantly RB cord-015365-iqdi99pd 515 7 different different JJ cord-015365-iqdi99pd 515 8 between between IN cord-015365-iqdi99pd 515 9 the the DT cord-015365-iqdi99pd 515 10 groups group NNS cord-015365-iqdi99pd 515 11 ( ( -LRB- cord-015365-iqdi99pd 515 12 A a NN cord-015365-iqdi99pd 515 13 : : : cord-015365-iqdi99pd 515 14 25 25 CD cord-015365-iqdi99pd 515 15 % % NN cord-015365-iqdi99pd 515 16 , , , cord-015365-iqdi99pd 515 17 B b NN cord-015365-iqdi99pd 515 18 : : : cord-015365-iqdi99pd 515 19 18 18 CD cord-015365-iqdi99pd 515 20 % % NN cord-015365-iqdi99pd 515 21 , , , cord-015365-iqdi99pd 515 22 C c NN cord-015365-iqdi99pd 515 23 : : : cord-015365-iqdi99pd 515 24 33 33 CD cord-015365-iqdi99pd 515 25 % % NN cord-015365-iqdi99pd 515 26 ; ; : cord-015365-iqdi99pd 515 27 p p NN cord-015365-iqdi99pd 515 28 ¼ ¼ CD cord-015365-iqdi99pd 515 29 0.03 0.03 CD cord-015365-iqdi99pd 515 30 ) ) -RRB- cord-015365-iqdi99pd 515 31 . . . cord-015365-iqdi99pd 516 1 Group Group NNP cord-015365-iqdi99pd 516 2 B B NNP cord-015365-iqdi99pd 516 3 had have VBD cord-015365-iqdi99pd 516 4 the the DT cord-015365-iqdi99pd 516 5 lowest low JJS cord-015365-iqdi99pd 516 6 incidence incidence NN cord-015365-iqdi99pd 516 7 of of IN cord-015365-iqdi99pd 516 8 severe severe JJ cord-015365-iqdi99pd 516 9 infection infection NN cord-015365-iqdi99pd 516 10 ( ( -LRB- cord-015365-iqdi99pd 516 11 A a NN cord-015365-iqdi99pd 516 12 : : : cord-015365-iqdi99pd 516 13 37 37 CD cord-015365-iqdi99pd 516 14 % % NN cord-015365-iqdi99pd 516 15 , , , cord-015365-iqdi99pd 516 16 B b NN cord-015365-iqdi99pd 516 17 : : : cord-015365-iqdi99pd 516 18 21 21 CD cord-015365-iqdi99pd 516 19 % % NN cord-015365-iqdi99pd 516 20 , , , cord-015365-iqdi99pd 516 21 C c NN cord-015365-iqdi99pd 516 22 : : : cord-015365-iqdi99pd 516 23 51 51 CD cord-015365-iqdi99pd 516 24 % % NN cord-015365-iqdi99pd 516 25 ; ; : cord-015365-iqdi99pd 516 26 p p NN cord-015365-iqdi99pd 516 27 < < XX cord-015365-iqdi99pd 516 28 0.01 0.01 CD cord-015365-iqdi99pd 516 29 ) ) -RRB- cord-015365-iqdi99pd 516 30 . . . cord-015365-iqdi99pd 517 1 CMV CMV NNP cord-015365-iqdi99pd 517 2 infection infection NN cord-015365-iqdi99pd 517 3 incidence incidence NN cord-015365-iqdi99pd 517 4 was be VBD cord-015365-iqdi99pd 517 5 higher high JJR cord-015365-iqdi99pd 517 6 in in IN cord-015365-iqdi99pd 517 7 group group NN cord-015365-iqdi99pd 517 8 C C NNP cord-015365-iqdi99pd 517 9 ( ( -LRB- cord-015365-iqdi99pd 517 10 35 35 CD cord-015365-iqdi99pd 517 11 % % NN cord-015365-iqdi99pd 517 12 ) ) -RRB- cord-015365-iqdi99pd 517 13 compared compare VBN cord-015365-iqdi99pd 517 14 to to IN cord-015365-iqdi99pd 517 15 groups group NNS cord-015365-iqdi99pd 517 16 A A NNP cord-015365-iqdi99pd 517 17 , , , cord-015365-iqdi99pd 517 18 B b NN cord-015365-iqdi99pd 517 19 ( ( -LRB- cord-015365-iqdi99pd 517 20 20 20 CD cord-015365-iqdi99pd 517 21 % % NN cord-015365-iqdi99pd 517 22 , , , cord-015365-iqdi99pd 517 23 23 23 CD cord-015365-iqdi99pd 517 24 % % NN cord-015365-iqdi99pd 517 25 ; ; : cord-015365-iqdi99pd 517 26 p p NN cord-015365-iqdi99pd 517 27 < < XX cord-015365-iqdi99pd 517 28 0.01 0.01 CD cord-015365-iqdi99pd 517 29 ) ) -RRB- cord-015365-iqdi99pd 517 30 . . . cord-015365-iqdi99pd 518 1 There there EX cord-015365-iqdi99pd 518 2 was be VBD cord-015365-iqdi99pd 518 3 no no DT cord-015365-iqdi99pd 518 4 significant significant JJ cord-015365-iqdi99pd 518 5 difference difference NN cord-015365-iqdi99pd 518 6 in in IN cord-015365-iqdi99pd 518 7 freedom freedom NN cord-015365-iqdi99pd 518 8 from from IN cord-015365-iqdi99pd 518 9 graft graft NN cord-015365-iqdi99pd 518 10 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 518 11 between between IN cord-015365-iqdi99pd 518 12 the the DT cord-015365-iqdi99pd 518 13 groups group NNS cord-015365-iqdi99pd 518 14 ( ( -LRB- cord-015365-iqdi99pd 518 15 A a NN cord-015365-iqdi99pd 518 16 : : : cord-015365-iqdi99pd 518 17 91 91 CD cord-015365-iqdi99pd 518 18 % % NN cord-015365-iqdi99pd 518 19 , , , cord-015365-iqdi99pd 518 20 B b NN cord-015365-iqdi99pd 518 21 : : : cord-015365-iqdi99pd 518 22 85 85 CD cord-015365-iqdi99pd 518 23 % % NN cord-015365-iqdi99pd 518 24 , , , cord-015365-iqdi99pd 518 25 C c NN cord-015365-iqdi99pd 518 26 : : : cord-015365-iqdi99pd 518 27 79 79 CD cord-015365-iqdi99pd 518 28 % % NN cord-015365-iqdi99pd 518 29 ; ; : cord-015365-iqdi99pd 518 30 p p NN cord-015365-iqdi99pd 518 31 ¼ ¼ NNP cord-015365-iqdi99pd 518 32 n.s n.s NNP cord-015365-iqdi99pd 518 33 . . NNP cord-015365-iqdi99pd 518 34 ) ) -RRB- cord-015365-iqdi99pd 518 35 . . . cord-015365-iqdi99pd 519 1 The the DT cord-015365-iqdi99pd 519 2 incidence incidence NN cord-015365-iqdi99pd 519 3 of of IN cord-015365-iqdi99pd 519 4 cancer cancer NN cord-015365-iqdi99pd 519 5 was be VBD cord-015365-iqdi99pd 519 6 similar similar JJ cord-015365-iqdi99pd 519 7 in in IN cord-015365-iqdi99pd 519 8 all all DT cord-015365-iqdi99pd 519 9 ATG ATG NNP cord-015365-iqdi99pd 519 10 groups group NNS cord-015365-iqdi99pd 519 11 ( ( -LRB- cord-015365-iqdi99pd 519 12 A a NN cord-015365-iqdi99pd 519 13 : : : cord-015365-iqdi99pd 519 14 3 3 CD cord-015365-iqdi99pd 519 15 % % NN cord-015365-iqdi99pd 519 16 , , , cord-015365-iqdi99pd 519 17 B b NN cord-015365-iqdi99pd 519 18 : : : cord-015365-iqdi99pd 519 19 7 7 CD cord-015365-iqdi99pd 519 20 % % NN cord-015365-iqdi99pd 519 21 , , , cord-015365-iqdi99pd 519 22 C c NN cord-015365-iqdi99pd 519 23 : : : cord-015365-iqdi99pd 519 24 11 11 CD cord-015365-iqdi99pd 519 25 % % NN cord-015365-iqdi99pd 519 26 ; ; : cord-015365-iqdi99pd 519 27 p p NN cord-015365-iqdi99pd 519 28 ¼ ¼ NNP cord-015365-iqdi99pd 519 29 n.s n.s NNP cord-015365-iqdi99pd 519 30 . . NNP cord-015365-iqdi99pd 519 31 ) ) -RRB- cord-015365-iqdi99pd 519 32 . . . cord-015365-iqdi99pd 520 1 Conclusions conclusion NNS cord-015365-iqdi99pd 520 2 . . . cord-015365-iqdi99pd 521 1 Different different JJ cord-015365-iqdi99pd 521 2 doses dose NNS cord-015365-iqdi99pd 521 3 of of IN cord-015365-iqdi99pd 521 4 ATG ATG NNP cord-015365-iqdi99pd 521 5 - - HYPH cord-015365-iqdi99pd 521 6 induction induction NN cord-015365-iqdi99pd 521 7 seem seem VBP cord-015365-iqdi99pd 521 8 to to TO cord-015365-iqdi99pd 521 9 have have VB cord-015365-iqdi99pd 521 10 a a DT cord-015365-iqdi99pd 521 11 significant significant JJ cord-015365-iqdi99pd 521 12 impact impact NN cord-015365-iqdi99pd 521 13 on on IN cord-015365-iqdi99pd 521 14 the the DT cord-015365-iqdi99pd 521 15 outcome outcome NN cord-015365-iqdi99pd 521 16 of of IN cord-015365-iqdi99pd 521 17 heart heart NN cord-015365-iqdi99pd 521 18 transplantation transplantation NN cord-015365-iqdi99pd 521 19 . . . cord-015365-iqdi99pd 522 1 There there EX cord-015365-iqdi99pd 522 2 is be VBZ cord-015365-iqdi99pd 522 3 a a DT cord-015365-iqdi99pd 522 4 strong strong JJ cord-015365-iqdi99pd 522 5 need need NN cord-015365-iqdi99pd 522 6 for for IN cord-015365-iqdi99pd 522 7 more more JJR cord-015365-iqdi99pd 522 8 studies study NNS cord-015365-iqdi99pd 522 9 on on IN cord-015365-iqdi99pd 522 10 optimization optimization NN cord-015365-iqdi99pd 522 11 of of IN cord-015365-iqdi99pd 522 12 ATG ATG NNP cord-015365-iqdi99pd 522 13 therapy therapy NN cord-015365-iqdi99pd 522 14 . . . cord-015365-iqdi99pd 523 1 Nighttime nighttime JJ cord-015365-iqdi99pd 523 2 kidney kidney NN cord-015365-iqdi99pd 523 3 transplantationa transplantationa NN cord-015365-iqdi99pd 523 4 risk risk NN cord-015365-iqdi99pd 523 5 or or CC cord-015365-iqdi99pd 523 6 a a DT cord-015365-iqdi99pd 523 7 need need NN cord-015365-iqdi99pd 523 8 ? ? . cord-015365-iqdi99pd 524 1 Background background NN cord-015365-iqdi99pd 524 2 . . . cord-015365-iqdi99pd 525 1 Kidney kidney NN cord-015365-iqdi99pd 525 2 transplantation transplantation NN cord-015365-iqdi99pd 525 3 is be VBZ cord-015365-iqdi99pd 525 4 performed perform VBN cord-015365-iqdi99pd 525 5 as as IN cord-015365-iqdi99pd 525 6 emergency emergency NN cord-015365-iqdi99pd 525 7 surgery surgery NN cord-015365-iqdi99pd 525 8 also also RB cord-015365-iqdi99pd 525 9 as as IN cord-015365-iqdi99pd 525 10 a a DT cord-015365-iqdi99pd 525 11 nighttime nighttime JJ cord-015365-iqdi99pd 525 12 procedure procedure NN cord-015365-iqdi99pd 525 13 to to TO cord-015365-iqdi99pd 525 14 reduce reduce VB cord-015365-iqdi99pd 525 15 cold cold JJ cord-015365-iqdi99pd 525 16 ischemia ischemia NN cord-015365-iqdi99pd 525 17 time time NN cord-015365-iqdi99pd 525 18 und und RB cord-015365-iqdi99pd 525 19 therefore therefore RB cord-015365-iqdi99pd 525 20 improve improve VB cord-015365-iqdi99pd 525 21 outcomes outcome NNS cord-015365-iqdi99pd 525 22 after after IN cord-015365-iqdi99pd 525 23 kidney kidney NN cord-015365-iqdi99pd 525 24 transplantation transplantation NN cord-015365-iqdi99pd 525 25 . . . cord-015365-iqdi99pd 526 1 However however RB cord-015365-iqdi99pd 526 2 , , , cord-015365-iqdi99pd 526 3 surgical surgical JJ cord-015365-iqdi99pd 526 4 procedures procedure NNS cord-015365-iqdi99pd 526 5 performed perform VBN cord-015365-iqdi99pd 526 6 during during IN cord-015365-iqdi99pd 526 7 nighttime nighttime NN cord-015365-iqdi99pd 526 8 in in IN cord-015365-iqdi99pd 526 9 the the DT cord-015365-iqdi99pd 526 10 context context NN cord-015365-iqdi99pd 526 11 of of IN cord-015365-iqdi99pd 526 12 24 24 CD cord-015365-iqdi99pd 526 13 hour hour NN cord-015365-iqdi99pd 526 14 shifts shift NNS cord-015365-iqdi99pd 526 15 and and CC cord-015365-iqdi99pd 526 16 sleep sleep NN cord-015365-iqdi99pd 526 17 deprivation deprivation NN cord-015365-iqdi99pd 526 18 have have VBP cord-015365-iqdi99pd 526 19 been be VBN cord-015365-iqdi99pd 526 20 associated associate VBN cord-015365-iqdi99pd 526 21 with with IN cord-015365-iqdi99pd 526 22 a a DT cord-015365-iqdi99pd 526 23 higher high JJR cord-015365-iqdi99pd 526 24 rate rate NN cord-015365-iqdi99pd 526 25 of of IN cord-015365-iqdi99pd 526 26 complications complication NNS cord-015365-iqdi99pd 526 27 than than IN cord-015365-iqdi99pd 526 28 elective elective JJ cord-015365-iqdi99pd 526 29 surgery surgery NN cord-015365-iqdi99pd 526 30 . . . cord-015365-iqdi99pd 527 1 The the DT cord-015365-iqdi99pd 527 2 aim aim NN cord-015365-iqdi99pd 527 3 of of IN cord-015365-iqdi99pd 527 4 this this DT cord-015365-iqdi99pd 527 5 retrospective retrospective JJ cord-015365-iqdi99pd 527 6 analysis analysis NN cord-015365-iqdi99pd 527 7 is be VBZ cord-015365-iqdi99pd 527 8 to to TO cord-015365-iqdi99pd 527 9 determine determine VB cord-015365-iqdi99pd 527 10 the the DT cord-015365-iqdi99pd 527 11 impact impact NN cord-015365-iqdi99pd 527 12 of of IN cord-015365-iqdi99pd 527 13 nighttime nighttime JJ cord-015365-iqdi99pd 527 14 surgery surgery NN cord-015365-iqdi99pd 527 15 on on IN cord-015365-iqdi99pd 527 16 the the DT cord-015365-iqdi99pd 527 17 outcome outcome NN cord-015365-iqdi99pd 527 18 after after IN cord-015365-iqdi99pd 527 19 kidney kidney NN cord-015365-iqdi99pd 527 20 transplantation transplantation NN cord-015365-iqdi99pd 527 21 . . . cord-015365-iqdi99pd 528 1 Methods method NNS cord-015365-iqdi99pd 528 2 . . . cord-015365-iqdi99pd 529 1 All all DT cord-015365-iqdi99pd 529 2 kidney kidney NN cord-015365-iqdi99pd 529 3 transplants transplant NNS cord-015365-iqdi99pd 529 4 from from IN cord-015365-iqdi99pd 529 5 cadaveric cadaveric JJ cord-015365-iqdi99pd 529 6 donors donor NNS cord-015365-iqdi99pd 529 7 performed perform VBN cord-015365-iqdi99pd 529 8 at at IN cord-015365-iqdi99pd 529 9 our -PRON- PRP$ cord-015365-iqdi99pd 529 10 center center NN cord-015365-iqdi99pd 529 11 from from IN cord-015365-iqdi99pd 529 12 January January NNP cord-015365-iqdi99pd 529 13 2000 2000 CD cord-015365-iqdi99pd 529 14 through through IN cord-015365-iqdi99pd 529 15 January January NNP cord-015365-iqdi99pd 529 16 2010 2010 CD cord-015365-iqdi99pd 530 1 ( ( -LRB- cord-015365-iqdi99pd 530 2 n n NNP cord-015365-iqdi99pd 530 3 ¼ ¼ NNP cord-015365-iqdi99pd 530 4 873 873 CD cord-015365-iqdi99pd 530 5 ) ) -RRB- cord-015365-iqdi99pd 530 6 were be VBD cord-015365-iqdi99pd 530 7 included include VBN cord-015365-iqdi99pd 530 8 in in IN cord-015365-iqdi99pd 530 9 this this DT cord-015365-iqdi99pd 530 10 retrospective retrospective JJ cord-015365-iqdi99pd 530 11 study study NN cord-015365-iqdi99pd 530 12 and and CC cord-015365-iqdi99pd 530 13 grouped grouped VBP cord-015365-iqdi99pd 530 14 according accord VBG cord-015365-iqdi99pd 530 15 to to IN cord-015365-iqdi99pd 530 16 the the DT cord-015365-iqdi99pd 530 17 time time NN cord-015365-iqdi99pd 530 18 of of IN cord-015365-iqdi99pd 530 19 surgery surgery NN cord-015365-iqdi99pd 530 20 : : : cord-015365-iqdi99pd 530 21 daytime daytime NN cord-015365-iqdi99pd 530 22 ( ( -LRB- cord-015365-iqdi99pd 530 23 from from IN cord-015365-iqdi99pd 530 24 8 8 CD cord-015365-iqdi99pd 530 25 a.m. a.m. NN cord-015365-iqdi99pd 530 26 to to IN cord-015365-iqdi99pd 530 27 8 8 CD cord-015365-iqdi99pd 530 28 p.m. p.m. NN cord-015365-iqdi99pd 530 29 , , , cord-015365-iqdi99pd 530 30 n n NN cord-015365-iqdi99pd 530 31 ¼ ¼ NNP cord-015365-iqdi99pd 530 32 608 608 CD cord-015365-iqdi99pd 530 33 ) ) -RRB- cord-015365-iqdi99pd 530 34 versus versus IN cord-015365-iqdi99pd 530 35 nighttime nighttime NN cord-015365-iqdi99pd 530 36 ( ( -LRB- cord-015365-iqdi99pd 530 37 from from IN cord-015365-iqdi99pd 530 38 8 8 CD cord-015365-iqdi99pd 530 39 p.m. p.m. NN cord-015365-iqdi99pd 530 40 to to IN cord-015365-iqdi99pd 530 41 8 8 CD cord-015365-iqdi99pd 530 42 a.m. a.m. NN cord-015365-iqdi99pd 530 43 , , , cord-015365-iqdi99pd 530 44 n n NN cord-015365-iqdi99pd 530 45 ¼ ¼ NNP cord-015365-iqdi99pd 530 46 265 265 CD cord-015365-iqdi99pd 530 47 ) ) -RRB- cord-015365-iqdi99pd 530 48 . . . cord-015365-iqdi99pd 531 1 Statistical statistical JJ cord-015365-iqdi99pd 531 2 analysis analysis NN cord-015365-iqdi99pd 531 3 compared compare VBN cord-015365-iqdi99pd 531 4 patient patient JJ cord-015365-iqdi99pd 531 5 and and CC cord-015365-iqdi99pd 531 6 graft graft NN cord-015365-iqdi99pd 531 7 survival survival NN cord-015365-iqdi99pd 531 8 in in IN cord-015365-iqdi99pd 531 9 the the DT cord-015365-iqdi99pd 531 10 two two CD cord-015365-iqdi99pd 531 11 groups group NNS cord-015365-iqdi99pd 531 12 , , , cord-015365-iqdi99pd 531 13 rate rate NN cord-015365-iqdi99pd 531 14 of of IN cord-015365-iqdi99pd 531 15 delayed delay VBN cord-015365-iqdi99pd 531 16 graft graft NN cord-015365-iqdi99pd 531 17 function function NN cord-015365-iqdi99pd 531 18 and and CC cord-015365-iqdi99pd 531 19 acute acute JJ cord-015365-iqdi99pd 531 20 rejection rejection NN cord-015365-iqdi99pd 531 21 as as RB cord-015365-iqdi99pd 531 22 well well RB cord-015365-iqdi99pd 531 23 as as IN cord-015365-iqdi99pd 531 24 surgical surgical JJ cord-015365-iqdi99pd 531 25 complications complication NNS cord-015365-iqdi99pd 531 26 . . . cord-015365-iqdi99pd 532 1 Results result NNS cord-015365-iqdi99pd 532 2 . . . cord-015365-iqdi99pd 533 1 5-year 5-year CD cord-015365-iqdi99pd 533 2 patient patient NN cord-015365-iqdi99pd 533 3 survival survival NN cord-015365-iqdi99pd 533 4 rates rate NNS cord-015365-iqdi99pd 533 5 of of IN cord-015365-iqdi99pd 533 6 87 87 CD cord-015365-iqdi99pd 533 7 % % NN cord-015365-iqdi99pd 533 8 and and CC cord-015365-iqdi99pd 533 9 85 85 CD cord-015365-iqdi99pd 533 10 % % NN cord-015365-iqdi99pd 533 11 and and CC cord-015365-iqdi99pd 533 12 10-year 10-year CD cord-015365-iqdi99pd 533 13 patient patient JJ cord-015365-iqdi99pd 533 14 survival survival NN cord-015365-iqdi99pd 533 15 rates rate NNS cord-015365-iqdi99pd 533 16 of of IN cord-015365-iqdi99pd 533 17 73 73 CD cord-015365-iqdi99pd 533 18 % % NN cord-015365-iqdi99pd 533 19 and and CC cord-015365-iqdi99pd 533 20 69 69 CD cord-015365-iqdi99pd 533 21 % % NN cord-015365-iqdi99pd 533 22 in in IN cord-015365-iqdi99pd 533 23 daytime daytime JJ cord-015365-iqdi99pd 533 24 and and CC cord-015365-iqdi99pd 533 25 nighttime nighttime JJ cord-015365-iqdi99pd 533 26 kidney kidney NN cord-015365-iqdi99pd 533 27 transplants transplant NNS cord-015365-iqdi99pd 533 28 did do VBD cord-015365-iqdi99pd 533 29 not not RB cord-015365-iqdi99pd 533 30 show show VB cord-015365-iqdi99pd 533 31 any any DT cord-015365-iqdi99pd 533 32 significant significant JJ cord-015365-iqdi99pd 533 33 difference difference NN cord-015365-iqdi99pd 533 34 . . . cord-015365-iqdi99pd 534 1 Also also RB cord-015365-iqdi99pd 534 2 , , , cord-015365-iqdi99pd 534 3 graft graft NN cord-015365-iqdi99pd 534 4 survival survival NN cord-015365-iqdi99pd 534 5 at at IN cord-015365-iqdi99pd 534 6 5 5 CD cord-015365-iqdi99pd 534 7 and and CC cord-015365-iqdi99pd 534 8 10 10 CD cord-015365-iqdi99pd 534 9 years year NNS cord-015365-iqdi99pd 534 10 did do VBD cord-015365-iqdi99pd 534 11 not not RB cord-015365-iqdi99pd 534 12 differ differ VB cord-015365-iqdi99pd 534 13 significantly significantly RB cord-015365-iqdi99pd 534 14 ( ( -LRB- cord-015365-iqdi99pd 534 15 85 85 CD cord-015365-iqdi99pd 534 16 % % NN cord-015365-iqdi99pd 534 17 versus versus IN cord-015365-iqdi99pd 534 18 85 85 CD cord-015365-iqdi99pd 534 19 % % NN cord-015365-iqdi99pd 534 20 and and CC cord-015365-iqdi99pd 534 21 69 69 CD cord-015365-iqdi99pd 534 22 % % NN cord-015365-iqdi99pd 534 23 versus versus IN cord-015365-iqdi99pd 534 24 60 60 CD cord-015365-iqdi99pd 534 25 % % NN cord-015365-iqdi99pd 534 26 ) ) -RRB- cord-015365-iqdi99pd 534 27 in in IN cord-015365-iqdi99pd 534 28 the the DT cord-015365-iqdi99pd 534 29 two two CD cord-015365-iqdi99pd 534 30 groups group NNS cord-015365-iqdi99pd 534 31 . . . cord-015365-iqdi99pd 535 1 Delayed delay VBN cord-015365-iqdi99pd 535 2 graft graft NN cord-015365-iqdi99pd 535 3 function function NN cord-015365-iqdi99pd 535 4 occurred occur VBD cord-015365-iqdi99pd 535 5 in in IN cord-015365-iqdi99pd 535 6 31 31 CD cord-015365-iqdi99pd 535 7 % % NN cord-015365-iqdi99pd 535 8 of of IN cord-015365-iqdi99pd 535 9 daytime daytime JJ cord-015365-iqdi99pd 535 10 transplants transplant NNS cord-015365-iqdi99pd 535 11 compared compare VBN cord-015365-iqdi99pd 535 12 to to IN cord-015365-iqdi99pd 535 13 37 37 CD cord-015365-iqdi99pd 535 14 % % NN cord-015365-iqdi99pd 535 15 of of IN cord-015365-iqdi99pd 535 16 nighttime nighttime JJ cord-015365-iqdi99pd 535 17 procedures procedure NNS cord-015365-iqdi99pd 535 18 ( ( -LRB- cord-015365-iqdi99pd 535 19 p p NN cord-015365-iqdi99pd 535 20 ¼ ¼ CD cord-015365-iqdi99pd 535 21 0.06 0.06 CD cord-015365-iqdi99pd 535 22 ) ) -RRB- cord-015365-iqdi99pd 535 23 . . . cord-015365-iqdi99pd 536 1 Acute acute JJ cord-015365-iqdi99pd 536 2 allograft allograft NN cord-015365-iqdi99pd 536 3 rejection rejection NN cord-015365-iqdi99pd 536 4 was be VBD cord-015365-iqdi99pd 536 5 observed observe VBN cord-015365-iqdi99pd 536 6 in in IN cord-015365-iqdi99pd 536 7 23 23 CD cord-015365-iqdi99pd 536 8 % % NN cord-015365-iqdi99pd 536 9 of of IN cord-015365-iqdi99pd 536 10 daytime daytime JJ cord-015365-iqdi99pd 536 11 graft graft NN cord-015365-iqdi99pd 536 12 recipients recipient NNS cord-015365-iqdi99pd 536 13 compared compare VBN cord-015365-iqdi99pd 536 14 to to IN cord-015365-iqdi99pd 536 15 18 18 CD cord-015365-iqdi99pd 536 16 % % NN cord-015365-iqdi99pd 536 17 of of IN cord-015365-iqdi99pd 536 18 nighttime nighttime JJ cord-015365-iqdi99pd 536 19 graft graft NN cord-015365-iqdi99pd 536 20 recipients recipient NNS cord-015365-iqdi99pd 536 21 ( ( -LRB- cord-015365-iqdi99pd 536 22 p p NN cord-015365-iqdi99pd 536 23 ¼ ¼ CD cord-015365-iqdi99pd 536 24 0.13 0.13 CD cord-015365-iqdi99pd 536 25 ) ) -RRB- cord-015365-iqdi99pd 536 26 . . . cord-015365-iqdi99pd 537 1 Furthermore furthermore RB cord-015365-iqdi99pd 537 2 , , , cord-015365-iqdi99pd 537 3 nighttime nighttime JJ cord-015365-iqdi99pd 537 4 procedures procedure NNS cord-015365-iqdi99pd 537 5 were be VBD cord-015365-iqdi99pd 537 6 associated associate VBN cord-015365-iqdi99pd 537 7 with with IN cord-015365-iqdi99pd 537 8 a a DT cord-015365-iqdi99pd 537 9 23 23 CD cord-015365-iqdi99pd 537 10 % % NN cord-015365-iqdi99pd 537 11 risk risk NN cord-015365-iqdi99pd 537 12 of of IN cord-015365-iqdi99pd 537 13 surgical surgical JJ cord-015365-iqdi99pd 537 14 complications complication NNS cord-015365-iqdi99pd 537 15 which which WDT cord-015365-iqdi99pd 537 16 was be VBD cord-015365-iqdi99pd 537 17 not not RB cord-015365-iqdi99pd 537 18 significantly significantly RB cord-015365-iqdi99pd 537 19 different different JJ cord-015365-iqdi99pd 537 20 from from IN cord-015365-iqdi99pd 537 21 daytime daytime JJ cord-015365-iqdi99pd 537 22 surgery surgery NN cord-015365-iqdi99pd 537 23 ( ( -LRB- cord-015365-iqdi99pd 537 24 22 22 CD cord-015365-iqdi99pd 537 25 % % NN cord-015365-iqdi99pd 537 26 , , , cord-015365-iqdi99pd 537 27 p p NN cord-015365-iqdi99pd 537 28 ¼ ¼ NNP cord-015365-iqdi99pd 537 29 0.7 0.7 CD cord-015365-iqdi99pd 537 30 ) ) -RRB- cord-015365-iqdi99pd 537 31 . . . cord-015365-iqdi99pd 538 1 Conclusions conclusion NNS cord-015365-iqdi99pd 538 2 . . . cord-015365-iqdi99pd 539 1 Nighttime nighttime JJ cord-015365-iqdi99pd 539 2 kidney kidney NN cord-015365-iqdi99pd 539 3 transplants transplant NNS cord-015365-iqdi99pd 539 4 are be VBP cord-015365-iqdi99pd 539 5 not not RB cord-015365-iqdi99pd 539 6 associated associate VBN cord-015365-iqdi99pd 539 7 with with IN cord-015365-iqdi99pd 539 8 a a DT cord-015365-iqdi99pd 539 9 higher high JJR cord-015365-iqdi99pd 539 10 surgical surgical JJ cord-015365-iqdi99pd 539 11 complication complication NN cord-015365-iqdi99pd 539 12 rate rate NN cord-015365-iqdi99pd 539 13 than than IN cord-015365-iqdi99pd 539 14 daytime daytime JJ cord-015365-iqdi99pd 539 15 procedures procedure NNS cord-015365-iqdi99pd 539 16 . . . cord-015365-iqdi99pd 540 1 Nighttime nighttime JJ cord-015365-iqdi99pd 540 2 kidney kidney NN cord-015365-iqdi99pd 540 3 transplant transplant NN cord-015365-iqdi99pd 540 4 procedures procedure NNS cord-015365-iqdi99pd 540 5 have have VBP cord-015365-iqdi99pd 540 6 the the DT cord-015365-iqdi99pd 540 7 same same JJ cord-015365-iqdi99pd 540 8 outcome outcome NN cord-015365-iqdi99pd 540 9 as as IN cord-015365-iqdi99pd 540 10 daytime daytime JJ cord-015365-iqdi99pd 540 11 transplants transplant NNS cord-015365-iqdi99pd 540 12 and and CC cord-015365-iqdi99pd 540 13 are be VBP cord-015365-iqdi99pd 540 14 necessary necessary JJ cord-015365-iqdi99pd 540 15 to to TO cord-015365-iqdi99pd 540 16 keep keep VB cord-015365-iqdi99pd 540 17 cold cold JJ cord-015365-iqdi99pd 540 18 ischemia ischemia NN cord-015365-iqdi99pd 540 19 time time NN cord-015365-iqdi99pd 540 20 as as RB cord-015365-iqdi99pd 540 21 short short JJ cord-015365-iqdi99pd 540 22 as as IN cord-015365-iqdi99pd 540 23 possible possible JJ cord-015365-iqdi99pd 540 24 . . . cord-015365-iqdi99pd 541 1 Ursolic Ursolic NNP cord-015365-iqdi99pd 541 2 acid acid VB cord-015365-iqdi99pd 541 3 a a DT cord-015365-iqdi99pd 541 4 constituent constituent NN cord-015365-iqdi99pd 541 5 of of IN cord-015365-iqdi99pd 541 6 Dwarf Dwarf NNP cord-015365-iqdi99pd 541 7 Elder Elder NNP cord-015365-iqdi99pd 541 8 ( ( -LRB- cord-015365-iqdi99pd 541 9 Sambucus Sambucus NNP cord-015365-iqdi99pd 541 10 ebulus ebulus NN cord-015365-iqdi99pd 541 11 ) ) -RRB- cord-015365-iqdi99pd 541 12 inhibits inhibit VBZ cord-015365-iqdi99pd 541 13 surface surface NN cord-015365-iqdi99pd 541 14 expression expression NN cord-015365-iqdi99pd 541 15 of of IN cord-015365-iqdi99pd 541 16 endothelial endothelial JJ cord-015365-iqdi99pd 541 17 adhesion adhesion NN cord-015365-iqdi99pd 541 18 molecules molecule NNS cord-015365-iqdi99pd 541 19 and and CC cord-015365-iqdi99pd 541 20 prevents prevent VBZ cord-015365-iqdi99pd 541 21 intimal intimal JJ cord-015365-iqdi99pd 541 22 hyperplasia hyperplasia NN cord-015365-iqdi99pd 541 23 in in IN cord-015365-iqdi99pd 541 24 an an DT cord-015365-iqdi99pd 541 25 in in IN cord-015365-iqdi99pd 541 26 vivo vivo NN cord-015365-iqdi99pd 541 27 model model NN cord-015365-iqdi99pd 541 28 for for IN cord-015365-iqdi99pd 541 29 bypass bypass NN cord-015365-iqdi99pd 541 30 surgery surgery NN cord-015365-iqdi99pd 541 31 Background background NN cord-015365-iqdi99pd 541 32 . . . cord-015365-iqdi99pd 542 1 In in IN cord-015365-iqdi99pd 542 2 a a DT cord-015365-iqdi99pd 542 3 recent recent JJ cord-015365-iqdi99pd 542 4 study study NN cord-015365-iqdi99pd 542 5 for for IN cord-015365-iqdi99pd 542 6 the the DT cord-015365-iqdi99pd 542 7 identification identification NN cord-015365-iqdi99pd 542 8 of of IN cord-015365-iqdi99pd 542 9 compounds compound NNS cord-015365-iqdi99pd 542 10 capable capable JJ cord-015365-iqdi99pd 542 11 of of IN cord-015365-iqdi99pd 542 12 inhibiting inhibit VBG cord-015365-iqdi99pd 542 13 VCAM-1 VCAM-1 NNP cord-015365-iqdi99pd 542 14 expression expression NN cord-015365-iqdi99pd 542 15 we -PRON- PRP cord-015365-iqdi99pd 542 16 isolated isolate VBD cord-015365-iqdi99pd 542 17 ursolic ursolic JJ cord-015365-iqdi99pd 542 18 acid acid NN cord-015365-iqdi99pd 542 19 ( ( -LRB- cord-015365-iqdi99pd 542 20 UA UA NNP cord-015365-iqdi99pd 542 21 ) ) -RRB- cord-015365-iqdi99pd 542 22 from from IN cord-015365-iqdi99pd 542 23 extracts extract NNS cord-015365-iqdi99pd 542 24 of of IN cord-015365-iqdi99pd 542 25 Dwarf Dwarf NNP cord-015365-iqdi99pd 542 26 Elder Elder NNP cord-015365-iqdi99pd 542 27 . . . cord-015365-iqdi99pd 543 1 Herein herein RB cord-015365-iqdi99pd 543 2 , , , cord-015365-iqdi99pd 543 3 we -PRON- PRP cord-015365-iqdi99pd 543 4 analyse analyse VBP cord-015365-iqdi99pd 543 5 the the DT cord-015365-iqdi99pd 543 6 mechanism mechanism NN cord-015365-iqdi99pd 543 7 of of IN cord-015365-iqdi99pd 543 8 action action NN cord-015365-iqdi99pd 543 9 and and CC cord-015365-iqdi99pd 543 10 the the DT cord-015365-iqdi99pd 543 11 in in IN cord-015365-iqdi99pd 543 12 vivo vivo NN cord-015365-iqdi99pd 543 13 applicability applicability NN cord-015365-iqdi99pd 543 14 of of IN cord-015365-iqdi99pd 543 15 the the DT cord-015365-iqdi99pd 543 16 compound compound NN cord-015365-iqdi99pd 543 17 in in IN cord-015365-iqdi99pd 543 18 a a DT cord-015365-iqdi99pd 543 19 setting setting NN cord-015365-iqdi99pd 543 20 for for IN cord-015365-iqdi99pd 543 21 venous venous JJ cord-015365-iqdi99pd 543 22 bypass bypass NN cord-015365-iqdi99pd 543 23 graft graft NN cord-015365-iqdi99pd 543 24 intimal intimal JJ cord-015365-iqdi99pd 543 25 hyperplasia hyperplasia NN cord-015365-iqdi99pd 543 26 . . . cord-015365-iqdi99pd 544 1 Methods method NNS cord-015365-iqdi99pd 544 2 and and CC cord-015365-iqdi99pd 544 3 Results result NNS cord-015365-iqdi99pd 544 4 . . . cord-015365-iqdi99pd 545 1 Our -PRON- PRP$ cord-015365-iqdi99pd 545 2 analyses analysis NNS cord-015365-iqdi99pd 545 3 indicate indicate VBP cord-015365-iqdi99pd 545 4 that that IN cord-015365-iqdi99pd 545 5 UA UA NNP cord-015365-iqdi99pd 545 6 does do VBZ cord-015365-iqdi99pd 545 7 not not RB cord-015365-iqdi99pd 545 8 interfere interfere VB cord-015365-iqdi99pd 545 9 with with IN cord-015365-iqdi99pd 545 10 the the DT cord-015365-iqdi99pd 545 11 adhesion adhesion NN cord-015365-iqdi99pd 545 12 molecule molecule NN cord-015365-iqdi99pd 545 13 expression expression NN cord-015365-iqdi99pd 545 14 pathway pathway NN cord-015365-iqdi99pd 545 15 at at IN cord-015365-iqdi99pd 545 16 or or CC cord-015365-iqdi99pd 545 17 upstream upstream RB cord-015365-iqdi99pd 545 18 of of IN cord-015365-iqdi99pd 545 19 NFK NFK NNP cord-015365-iqdi99pd 545 20 - - HYPH cord-015365-iqdi99pd 545 21 B B NNP cord-015365-iqdi99pd 545 22 , , , cord-015365-iqdi99pd 545 23 as as IN cord-015365-iqdi99pd 545 24 NFK NFK NNP cord-015365-iqdi99pd 545 25 - - HYPH cord-015365-iqdi99pd 545 26 B b NN cord-015365-iqdi99pd 545 27 translocation translocation NN cord-015365-iqdi99pd 545 28 and and CC cord-015365-iqdi99pd 545 29 NFK NFK NNP cord-015365-iqdi99pd 545 30 - - HYPH cord-015365-iqdi99pd 545 31 B b NN cord-015365-iqdi99pd 545 32 mediated mediate VBN cord-015365-iqdi99pd 545 33 transcription transcription NN cord-015365-iqdi99pd 545 34 were be VBD cord-015365-iqdi99pd 545 35 not not RB cord-015365-iqdi99pd 545 36 affected affect VBN cord-015365-iqdi99pd 545 37 by by IN cord-015365-iqdi99pd 545 38 UA UA NNP cord-015365-iqdi99pd 545 39 . . . cord-015365-iqdi99pd 546 1 However however RB cord-015365-iqdi99pd 546 2 , , , cord-015365-iqdi99pd 546 3 UA UA NNP cord-015365-iqdi99pd 546 4 inhibited inhibited JJ cord-015365-iqdi99pd 546 5 adhesion adhesion NN cord-015365-iqdi99pd 546 6 molecule molecule NN cord-015365-iqdi99pd 546 7 protein protein NN cord-015365-iqdi99pd 546 8 synthesis synthesis NN cord-015365-iqdi99pd 546 9 suggesting suggest VBG cord-015365-iqdi99pd 546 10 an an DT cord-015365-iqdi99pd 546 11 inference inference NN cord-015365-iqdi99pd 546 12 with with IN cord-015365-iqdi99pd 546 13 the the DT cord-015365-iqdi99pd 546 14 translation translation NN cord-015365-iqdi99pd 546 15 of of IN cord-015365-iqdi99pd 546 16 adhesion adhesion NN cord-015365-iqdi99pd 546 17 molecules molecule NNS cord-015365-iqdi99pd 546 18 . . . cord-015365-iqdi99pd 547 1 In in IN cord-015365-iqdi99pd 547 2 an an DT cord-015365-iqdi99pd 547 3 in in IN cord-015365-iqdi99pd 547 4 - - HYPH cord-015365-iqdi99pd 547 5 vivo vivo FW cord-015365-iqdi99pd 547 6 rat rat NN cord-015365-iqdi99pd 547 7 model model NN cord-015365-iqdi99pd 547 8 for for IN cord-015365-iqdi99pd 547 9 vein vein NN cord-015365-iqdi99pd 547 10 graft graft NN cord-015365-iqdi99pd 547 11 disease disease NN cord-015365-iqdi99pd 547 12 , , , cord-015365-iqdi99pd 547 13 UA UA NNP cord-015365-iqdi99pd 547 14 - - HYPH cord-015365-iqdi99pd 547 15 containing contain VBG cord-015365-iqdi99pd 547 16 Sambucus Sambucus NNP cord-015365-iqdi99pd 547 17 extracts extract NNS cord-015365-iqdi99pd 547 18 inhibited inhibit VBD cord-015365-iqdi99pd 547 19 endothelial endothelial JJ cord-015365-iqdi99pd 547 20 VCAM-1 VCAM-1 NNP cord-015365-iqdi99pd 547 21 expression expression NN cord-015365-iqdi99pd 547 22 , , , cord-015365-iqdi99pd 547 23 induced induce VBN cord-015365-iqdi99pd 547 24 cell cell NN cord-015365-iqdi99pd 547 25 death death NN cord-015365-iqdi99pd 547 26 in in IN cord-015365-iqdi99pd 547 27 smooth smooth JJ cord-015365-iqdi99pd 547 28 muscle muscle NN cord-015365-iqdi99pd 547 29 cells cell NNS cord-015365-iqdi99pd 547 30 , , , cord-015365-iqdi99pd 547 31 and and CC cord-015365-iqdi99pd 547 32 inhibited inhibit VBN cord-015365-iqdi99pd 547 33 intimal intimal JJ cord-015365-iqdi99pd 547 34 hyperplasia hyperplasia NN cord-015365-iqdi99pd 547 35 in in IN cord-015365-iqdi99pd 547 36 a a DT cord-015365-iqdi99pd 547 37 rat rat NN cord-015365-iqdi99pd 547 38 model model NN cord-015365-iqdi99pd 547 39 for for IN cord-015365-iqdi99pd 547 40 venous venous JJ cord-015365-iqdi99pd 547 41 bypass bypass NN cord-015365-iqdi99pd 547 42 graft graft NN cord-015365-iqdi99pd 547 43 disease disease NN cord-015365-iqdi99pd 547 44 . . . cord-015365-iqdi99pd 548 1 Conclusions conclusion NNS cord-015365-iqdi99pd 548 2 . . . cord-015365-iqdi99pd 549 1 Our -PRON- PRP$ cord-015365-iqdi99pd 549 2 results result NNS cord-015365-iqdi99pd 549 3 suggest suggest VBP cord-015365-iqdi99pd 549 4 that that IN cord-015365-iqdi99pd 549 5 the the DT cord-015365-iqdi99pd 549 6 inhibition inhibition NN cord-015365-iqdi99pd 549 7 of of IN cord-015365-iqdi99pd 549 8 VCAM-1 VCAM-1 NNP cord-015365-iqdi99pd 549 9 expression expression NN cord-015365-iqdi99pd 549 10 constitutes constitute VBZ cord-015365-iqdi99pd 549 11 a a DT cord-015365-iqdi99pd 549 12 valuable valuable JJ cord-015365-iqdi99pd 549 13 target target NN cord-015365-iqdi99pd 549 14 for for IN cord-015365-iqdi99pd 549 15 drug drug NN cord-015365-iqdi99pd 549 16 discovery discovery NN cord-015365-iqdi99pd 549 17 in in IN cord-015365-iqdi99pd 549 18 the the DT cord-015365-iqdi99pd 549 19 field field NN cord-015365-iqdi99pd 549 20 of of IN cord-015365-iqdi99pd 549 21 cardiovascular cardiovascular JJ cord-015365-iqdi99pd 549 22 research research NN cord-015365-iqdi99pd 549 23 . . . cord-015365-iqdi99pd 550 1 UA UA NNP cord-015365-iqdi99pd 550 2 may may MD cord-015365-iqdi99pd 550 3 be be VB cord-015365-iqdi99pd 550 4 an an DT cord-015365-iqdi99pd 550 5 interesting interesting JJ cord-015365-iqdi99pd 550 6 agent agent NN cord-015365-iqdi99pd 550 7 in in IN cord-015365-iqdi99pd 550 8 the the DT cord-015365-iqdi99pd 550 9 prevention prevention NN cord-015365-iqdi99pd 550 10 of of IN cord-015365-iqdi99pd 550 11 vein vein NN cord-015365-iqdi99pd 550 12 graft graft NN cord-015365-iqdi99pd 550 13 disease disease NN cord-015365-iqdi99pd 550 14 and and CC cord-015365-iqdi99pd 550 15 graft graft NN cord-015365-iqdi99pd 550 16 failure failure NN cord-015365-iqdi99pd 550 17 . . . cord-015365-iqdi99pd 551 1 The the DT cord-015365-iqdi99pd 551 2 killer killer NN cord-015365-iqdi99pd 551 3 - - HYPH cord-015365-iqdi99pd 551 4 cell cell NN cord-015365-iqdi99pd 551 5 immunoglobulin immunoglobulin NN cord-015365-iqdi99pd 551 6 - - HYPH cord-015365-iqdi99pd 551 7 like like JJ cord-015365-iqdi99pd 551 8 receptor receptor NN cord-015365-iqdi99pd 551 9 ( ( -LRB- cord-015365-iqdi99pd 551 10 KIR KIR NNP cord-015365-iqdi99pd 551 11 ) ) -RRB- cord-015365-iqdi99pd 551 12 genotype genotype NN cord-015365-iqdi99pd 551 13 correlates correlate VBZ cord-015365-iqdi99pd 551 14 with with IN cord-015365-iqdi99pd 551 15 acute acute JJ cord-015365-iqdi99pd 551 16 kidney kidney NN cord-015365-iqdi99pd 551 17 failure failure NN cord-015365-iqdi99pd 551 18 in in IN cord-015365-iqdi99pd 551 19 the the DT cord-015365-iqdi99pd 551 20 early early JJ cord-015365-iqdi99pd 551 21 post post JJ cord-015365-iqdi99pd 551 22 - - JJ cord-015365-iqdi99pd 551 23 liver liver JJ cord-015365-iqdi99pd 551 24 transplantation transplantation NN cord-015365-iqdi99pd 551 25 period period NN cord-015365-iqdi99pd 552 1 Acute acute JJ cord-015365-iqdi99pd 552 2 renal renal JJ cord-015365-iqdi99pd 552 3 failure failure NN cord-015365-iqdi99pd 552 4 ( ( -LRB- cord-015365-iqdi99pd 552 5 ARF ARF NNP cord-015365-iqdi99pd 552 6 ) ) -RRB- cord-015365-iqdi99pd 552 7 is be VBZ cord-015365-iqdi99pd 552 8 a a DT cord-015365-iqdi99pd 552 9 major major JJ cord-015365-iqdi99pd 552 10 complication complication NN cord-015365-iqdi99pd 552 11 following follow VBG cord-015365-iqdi99pd 552 12 liver liver NN cord-015365-iqdi99pd 552 13 transplantation transplantation NN cord-015365-iqdi99pd 552 14 ( ( -LRB- cord-015365-iqdi99pd 552 15 LT LT NNP cord-015365-iqdi99pd 552 16 ) ) -RRB- cord-015365-iqdi99pd 552 17 leading lead VBG cord-015365-iqdi99pd 552 18 up up RP cord-015365-iqdi99pd 552 19 to to IN cord-015365-iqdi99pd 552 20 chronic chronic JJ cord-015365-iqdi99pd 552 21 end end NN cord-015365-iqdi99pd 552 22 - - HYPH cord-015365-iqdi99pd 552 23 stage stage NN cord-015365-iqdi99pd 552 24 renal renal JJ cord-015365-iqdi99pd 552 25 disease disease NN cord-015365-iqdi99pd 552 26 . . . cord-015365-iqdi99pd 553 1 The the DT cord-015365-iqdi99pd 553 2 etiology etiology NN cord-015365-iqdi99pd 553 3 of of IN cord-015365-iqdi99pd 553 4 post post JJ cord-015365-iqdi99pd 553 5 - - JJ cord-015365-iqdi99pd 553 6 LT LT NNP cord-015365-iqdi99pd 553 7 impairment impairment NN cord-015365-iqdi99pd 553 8 is be VBZ cord-015365-iqdi99pd 553 9 multifactorial multifactorial JJ cord-015365-iqdi99pd 553 10 , , , cord-015365-iqdi99pd 553 11 but but CC cord-015365-iqdi99pd 553 12 it -PRON- PRP cord-015365-iqdi99pd 553 13 is be VBZ cord-015365-iqdi99pd 553 14 suggested suggest VBN cord-015365-iqdi99pd 553 15 that that IN cord-015365-iqdi99pd 553 16 e.g. e.g. RB cord-015365-iqdi99pd 553 17 during during IN cord-015365-iqdi99pd 553 18 ischemia ischemia NN cord-015365-iqdi99pd 553 19 initial initial JJ cord-015365-iqdi99pd 553 20 insults insult NNS cord-015365-iqdi99pd 553 21 provoke provoke VBP cord-015365-iqdi99pd 553 22 morphological morphological JJ cord-015365-iqdi99pd 553 23 and and CC cord-015365-iqdi99pd 553 24 functional functional JJ cord-015365-iqdi99pd 553 25 changes change NNS cord-015365-iqdi99pd 553 26 within within IN cord-015365-iqdi99pd 553 27 the the DT cord-015365-iqdi99pd 553 28 vascular vascular JJ cord-015365-iqdi99pd 553 29 and and CC cord-015365-iqdi99pd 553 30 tubular tubular JJ cord-015365-iqdi99pd 553 31 epithelium epithelium NN cord-015365-iqdi99pd 553 32 . . . cord-015365-iqdi99pd 554 1 Because because IN cord-015365-iqdi99pd 554 2 it -PRON- PRP cord-015365-iqdi99pd 554 3 has have VBZ cord-015365-iqdi99pd 554 4 been be VBN cord-015365-iqdi99pd 554 5 demonstrated demonstrate VBN cord-015365-iqdi99pd 554 6 that that IN cord-015365-iqdi99pd 554 7 ischemic ischemic JJ cord-015365-iqdi99pd 554 8 ARF arf NN cord-015365-iqdi99pd 554 9 can can MD cord-015365-iqdi99pd 554 10 occur occur VB cord-015365-iqdi99pd 554 11 in in IN cord-015365-iqdi99pd 554 12 the the DT cord-015365-iqdi99pd 554 13 absence absence NN cord-015365-iqdi99pd 554 14 of of IN cord-015365-iqdi99pd 554 15 classical classical JJ cord-015365-iqdi99pd 554 16 T t NN cord-015365-iqdi99pd 554 17 cell cell NN cord-015365-iqdi99pd 554 18 function function NN cord-015365-iqdi99pd 554 19 and and CC cord-015365-iqdi99pd 554 20 that that IN cord-015365-iqdi99pd 554 21 natural natural JJ cord-015365-iqdi99pd 554 22 killer killer NN cord-015365-iqdi99pd 554 23 ( ( -LRB- cord-015365-iqdi99pd 554 24 NK NK NNP cord-015365-iqdi99pd 554 25 ) ) -RRB- cord-015365-iqdi99pd 554 26 cells cell NNS cord-015365-iqdi99pd 554 27 can can MD cord-015365-iqdi99pd 554 28 kill kill VB cord-015365-iqdi99pd 554 29 syngeneic syngeneic NNS cord-015365-iqdi99pd 554 30 tubular tubular JJ cord-015365-iqdi99pd 554 31 epithelial epithelial JJ cord-015365-iqdi99pd 554 32 cells cell NNS cord-015365-iqdi99pd 554 33 in in IN cord-015365-iqdi99pd 554 34 vitro vitro FW cord-015365-iqdi99pd 554 35 , , , cord-015365-iqdi99pd 554 36 we -PRON- PRP cord-015365-iqdi99pd 554 37 aimed aim VBD cord-015365-iqdi99pd 554 38 to to TO cord-015365-iqdi99pd 554 39 elucidate elucidate VB cord-015365-iqdi99pd 554 40 the the DT cord-015365-iqdi99pd 554 41 role role NN cord-015365-iqdi99pd 554 42 of of IN cord-015365-iqdi99pd 554 43 NK NK NNP cord-015365-iqdi99pd 554 44 cells cell NNS cord-015365-iqdi99pd 554 45 and and CC cord-015365-iqdi99pd 554 46 their -PRON- PRP$ cord-015365-iqdi99pd 554 47 receptors receptor NNS cord-015365-iqdi99pd 554 48 in in IN cord-015365-iqdi99pd 554 49 the the DT cord-015365-iqdi99pd 554 50 context context NN cord-015365-iqdi99pd 554 51 of of IN cord-015365-iqdi99pd 554 52 early early JJ cord-015365-iqdi99pd 554 53 post post JJ cord-015365-iqdi99pd 554 54 - - JJ cord-015365-iqdi99pd 554 55 liver liver JJ cord-015365-iqdi99pd 554 56 transplant transplant NN cord-015365-iqdi99pd 554 57 ARI ARI NNP cord-015365-iqdi99pd 554 58 and and CC cord-015365-iqdi99pd 554 59 ARF ARF NNP cord-015365-iqdi99pd 554 60 more more RBR cord-015365-iqdi99pd 554 61 precisely precisely RB cord-015365-iqdi99pd 554 62 . . . cord-015365-iqdi99pd 555 1 Patients patient NNS cord-015365-iqdi99pd 555 2 with with IN cord-015365-iqdi99pd 555 3 impaired impaired JJ cord-015365-iqdi99pd 555 4 kidney kidney NN cord-015365-iqdi99pd 555 5 function function NN cord-015365-iqdi99pd 555 6 ( ( -LRB- cord-015365-iqdi99pd 555 7 serum serum NN cord-015365-iqdi99pd 555 8 creatinine creatinine NN cord-015365-iqdi99pd 555 9 > > XX cord-015365-iqdi99pd 555 10 1.2 1.2 CD cord-015365-iqdi99pd 555 11 mg mg NNP cord-015365-iqdi99pd 555 12 / / SYM cord-015365-iqdi99pd 555 13 dl dl NNP cord-015365-iqdi99pd 555 14 , , , cord-015365-iqdi99pd 555 15 n n NNP cord-015365-iqdi99pd 555 16 ¼ ¼ NNP cord-015365-iqdi99pd 555 17 13 13 CD cord-015365-iqdi99pd 555 18 ) ) -RRB- cord-015365-iqdi99pd 555 19 illustrated illustrate VBN cord-015365-iqdi99pd 555 20 heightened heighten VBD cord-015365-iqdi99pd 555 21 peripheral peripheral JJ cord-015365-iqdi99pd 555 22 NK NK NNP cord-015365-iqdi99pd 555 23 cell cell NN cord-015365-iqdi99pd 555 24 frequencies frequency NNS cord-015365-iqdi99pd 555 25 prior prior RB cord-015365-iqdi99pd 555 26 to to IN cord-015365-iqdi99pd 555 27 LT LT NNP cord-015365-iqdi99pd 555 28 compared compare VBN cord-015365-iqdi99pd 555 29 with with IN cord-015365-iqdi99pd 555 30 patients patient NNS cord-015365-iqdi99pd 555 31 showing show VBG cord-015365-iqdi99pd 555 32 stable stable JJ cord-015365-iqdi99pd 555 33 renal renal JJ cord-015365-iqdi99pd 555 34 function function NN cord-015365-iqdi99pd 555 35 ( ( -LRB- cord-015365-iqdi99pd 555 36 n n NN cord-015365-iqdi99pd 555 37 ¼ ¼ NNP cord-015365-iqdi99pd 555 38 9 9 CD cord-015365-iqdi99pd 555 39 ) ) -RRB- cord-015365-iqdi99pd 555 40 ( ( -LRB- cord-015365-iqdi99pd 555 41 17.22 17.22 CD cord-015365-iqdi99pd 555 42 % % NN cord-015365-iqdi99pd 555 43 AE AE NNP cord-015365-iqdi99pd 555 44 10.56 10.56 CD cord-015365-iqdi99pd 555 45 versus versus IN cord-015365-iqdi99pd 555 46 12.98 12.98 CD cord-015365-iqdi99pd 555 47 % % NN cord-015365-iqdi99pd 555 48 AE AE NNP cord-015365-iqdi99pd 555 49 9.09 9.09 CD cord-015365-iqdi99pd 555 50 ) ) -RRB- cord-015365-iqdi99pd 555 51 . . . cord-015365-iqdi99pd 556 1 We -PRON- PRP cord-015365-iqdi99pd 556 2 further further RB cord-015365-iqdi99pd 556 3 tested test VBD cord-015365-iqdi99pd 556 4 retrospectively retrospectively RB cord-015365-iqdi99pd 556 5 89 89 CD cord-015365-iqdi99pd 556 6 liver liver NN cord-015365-iqdi99pd 556 7 transplant transplant NN cord-015365-iqdi99pd 556 8 recipients recipient NNS cord-015365-iqdi99pd 556 9 for for IN cord-015365-iqdi99pd 556 10 their -PRON- PRP$ cord-015365-iqdi99pd 556 11 killer killer NN cord-015365-iqdi99pd 556 12 - - HYPH cord-015365-iqdi99pd 556 13 cell cell NN cord-015365-iqdi99pd 556 14 immunoglobulin immunoglobulin NN cord-015365-iqdi99pd 556 15 - - HYPH cord-015365-iqdi99pd 556 16 like like JJ cord-015365-iqdi99pd 556 17 receptor receptor NN cord-015365-iqdi99pd 556 18 ( ( -LRB- cord-015365-iqdi99pd 556 19 KIR KIR NNP cord-015365-iqdi99pd 556 20 ) ) -RRB- cord-015365-iqdi99pd 556 21 genotype genotype NN cord-015365-iqdi99pd 556 22 and and CC cord-015365-iqdi99pd 556 23 the the DT cord-015365-iqdi99pd 556 24 risk risk NN cord-015365-iqdi99pd 556 25 of of IN cord-015365-iqdi99pd 556 26 ARI ARI NNP cord-015365-iqdi99pd 556 27 / / SYM cord-015365-iqdi99pd 556 28 ARF ARF NNP cord-015365-iqdi99pd 556 29 . . . cord-015365-iqdi99pd 557 1 During during IN cord-015365-iqdi99pd 557 2 the the DT cord-015365-iqdi99pd 557 3 first first JJ cord-015365-iqdi99pd 557 4 week week NN cord-015365-iqdi99pd 557 5 post post NN cord-015365-iqdi99pd 557 6 - - NNP cord-015365-iqdi99pd 557 7 LT LT NNP cord-015365-iqdi99pd 557 8 , , , cord-015365-iqdi99pd 557 9 ARI ARI NNP cord-015365-iqdi99pd 557 10 occurred occur VBD cord-015365-iqdi99pd 557 11 in in IN cord-015365-iqdi99pd 557 12 12 12 CD cord-015365-iqdi99pd 557 13 % % NN cord-015365-iqdi99pd 557 14 and and CC cord-015365-iqdi99pd 557 15 ARF arf NN cord-015365-iqdi99pd 557 16 in in IN cord-015365-iqdi99pd 557 17 22 22 CD cord-015365-iqdi99pd 557 18 % % NN cord-015365-iqdi99pd 557 19 of of IN cord-015365-iqdi99pd 557 20 the the DT cord-015365-iqdi99pd 557 21 patients patient NNS cord-015365-iqdi99pd 557 22 . . . cord-015365-iqdi99pd 558 1 ARI ARI NNP cord-015365-iqdi99pd 558 2 was be VBD cord-015365-iqdi99pd 558 3 a a DT cord-015365-iqdi99pd 558 4 significant significant JJ cord-015365-iqdi99pd 558 5 risk risk NN cord-015365-iqdi99pd 558 6 factor factor NN cord-015365-iqdi99pd 558 7 for for IN cord-015365-iqdi99pd 558 8 acute acute JJ cord-015365-iqdi99pd 558 9 rejection rejection NN cord-015365-iqdi99pd 558 10 ( ( -LRB- cord-015365-iqdi99pd 558 11 p p NN cord-015365-iqdi99pd 558 12 ¼ ¼ CD cord-015365-iqdi99pd 558 13 0.0009 0.0009 CD cord-015365-iqdi99pd 558 14 ) ) -RRB- cord-015365-iqdi99pd 558 15 and and CC cord-015365-iqdi99pd 558 16 ARF ARF NNP cord-015365-iqdi99pd 558 17 led lead VBD cord-015365-iqdi99pd 558 18 to to IN cord-015365-iqdi99pd 558 19 elevated elevated JJ cord-015365-iqdi99pd 558 20 serum serum NN cord-015365-iqdi99pd 558 21 creatinine creatinine NN cord-015365-iqdi99pd 558 22 levels level NNS cord-015365-iqdi99pd 558 23 ( ( -LRB- cord-015365-iqdi99pd 558 24 > > NFP cord-015365-iqdi99pd 558 25 1.2 1.2 CD cord-015365-iqdi99pd 558 26 mg mg NNP cord-015365-iqdi99pd 558 27 / / SYM cord-015365-iqdi99pd 558 28 dl dl NNP cord-015365-iqdi99pd 558 29 ) ) -RRB- cord-015365-iqdi99pd 558 30 at at IN cord-015365-iqdi99pd 558 31 the the DT cord-015365-iqdi99pd 558 32 time time NN cord-015365-iqdi99pd 558 33 of of IN cord-015365-iqdi99pd 558 34 hospital hospital NN cord-015365-iqdi99pd 558 35 discharge discharge NN cord-015365-iqdi99pd 559 1 ( ( -LRB- cord-015365-iqdi99pd 559 2 p p NN cord-015365-iqdi99pd 559 3 ¼ ¼ CD cord-015365-iqdi99pd 559 4 0.008 0.008 CD cord-015365-iqdi99pd 559 5 ) ) -RRB- cord-015365-iqdi99pd 559 6 . . . cord-015365-iqdi99pd 560 1 Interestingly interestingly RB cord-015365-iqdi99pd 560 2 , , , cord-015365-iqdi99pd 560 3 significantly significantly RB cord-015365-iqdi99pd 560 4 less less JJR cord-015365-iqdi99pd 560 5 patients patient NNS cord-015365-iqdi99pd 560 6 having have VBG cord-015365-iqdi99pd 560 7 a a DT cord-015365-iqdi99pd 560 8 homozygous homozygous JJ cord-015365-iqdi99pd 560 9 KIR KIR NNP cord-015365-iqdi99pd 560 10 haplotype haplotype NN cord-015365-iqdi99pd 560 11 A a DT cord-015365-iqdi99pd 561 1 /A /A NNP cord-015365-iqdi99pd 562 1 ( ( -LRB- cord-015365-iqdi99pd 562 2 char char NN cord-015365-iqdi99pd 562 3 - - HYPH cord-015365-iqdi99pd 562 4 acterized acterize VBN cord-015365-iqdi99pd 562 5 by by IN cord-015365-iqdi99pd 562 6 the the DT cord-015365-iqdi99pd 562 7 presence presence NN cord-015365-iqdi99pd 562 8 of of IN cord-015365-iqdi99pd 562 9 only only RB cord-015365-iqdi99pd 562 10 one one CD cord-015365-iqdi99pd 562 11 activating activate VBG cord-015365-iqdi99pd 562 12 KIR KIR NNP cord-015365-iqdi99pd 562 13 gene gene NN cord-015365-iqdi99pd 562 14 ) ) -RRB- cord-015365-iqdi99pd 562 15 displayed display VBD cord-015365-iqdi99pd 562 16 a a DT cord-015365-iqdi99pd 562 17 stable stable JJ cord-015365-iqdi99pd 562 18 early early JJ cord-015365-iqdi99pd 562 19 postoperative postoperative JJ cord-015365-iqdi99pd 562 20 kidney kidney NN cord-015365-iqdi99pd 562 21 function function NN cord-015365-iqdi99pd 562 22 , , , cord-015365-iqdi99pd 562 23 compared compare VBN cord-015365-iqdi99pd 562 24 to to IN cord-015365-iqdi99pd 562 25 patients patient NNS cord-015365-iqdi99pd 562 26 with with IN cord-015365-iqdi99pd 562 27 a a DT cord-015365-iqdi99pd 562 28 KIR KIR NNP cord-015365-iqdi99pd 562 29 haplotype haplotype NN cord-015365-iqdi99pd 562 30 B/ B/ NNP cord-015365-iqdi99pd 563 1 x x LS cord-015365-iqdi99pd 564 1 ( ( -LRB- cord-015365-iqdi99pd 564 2 more more JJR cord-015365-iqdi99pd 564 3 than than IN cord-015365-iqdi99pd 564 4 one one CD cord-015365-iqdi99pd 564 5 activating activate VBG cord-015365-iqdi99pd 564 6 receptor receptor NN cord-015365-iqdi99pd 564 7 ) ) -RRB- cord-015365-iqdi99pd 565 1 ( ( -LRB- cord-015365-iqdi99pd 565 2 p p NN cord-015365-iqdi99pd 565 3 ¼ ¼ CD cord-015365-iqdi99pd 565 4 0.025 0.025 CD cord-015365-iqdi99pd 565 5 , , , cord-015365-iqdi99pd 565 6 odds odd NNS cord-015365-iqdi99pd 565 7 ratio ratio NN cord-015365-iqdi99pd 565 8 2.3 2.3 CD cord-015365-iqdi99pd 565 9 , , , cord-015365-iqdi99pd 565 10 CI CI NNP cord-015365-iqdi99pd 565 11 ¼ ¼ NNP cord-015365-iqdi99pd 565 12 1.3 1.3 CD cord-015365-iqdi99pd 565 13 - - SYM cord-015365-iqdi99pd 565 14 3.9 3.9 CD cord-015365-iqdi99pd 565 15 ) ) -RRB- cord-015365-iqdi99pd 565 16 . . . cord-015365-iqdi99pd 566 1 Moreover moreover RB cord-015365-iqdi99pd 566 2 , , , cord-015365-iqdi99pd 566 3 the the DT cord-015365-iqdi99pd 566 4 absence absence NN cord-015365-iqdi99pd 566 5 of of IN cord-015365-iqdi99pd 566 6 KIR2DL2 KIR2DL2 NNP cord-015365-iqdi99pd 566 7 / / SYM cord-015365-iqdi99pd 566 8 DS2 DS2 NNP cord-015365-iqdi99pd 566 9 genes gene NNS cord-015365-iqdi99pd 566 10 significantly significantly RB cord-015365-iqdi99pd 566 11 influenced influence VBD cord-015365-iqdi99pd 566 12 the the DT cord-015365-iqdi99pd 566 13 risk risk NN cord-015365-iqdi99pd 566 14 of of IN cord-015365-iqdi99pd 566 15 ARF ARF NNP cord-015365-iqdi99pd 566 16 ( ( -LRB- cord-015365-iqdi99pd 566 17 p p NN cord-015365-iqdi99pd 566 18 ¼ ¼ CD cord-015365-iqdi99pd 566 19 0.05 0.05 CD cord-015365-iqdi99pd 566 20 ) ) -RRB- cord-015365-iqdi99pd 566 21 . . . cord-015365-iqdi99pd 567 1 A a DT cord-015365-iqdi99pd 567 2 multivariate multivariate JJ cord-015365-iqdi99pd 567 3 regression regression NN cord-015365-iqdi99pd 567 4 model model NN cord-015365-iqdi99pd 567 5 of of IN cord-015365-iqdi99pd 567 6 clinical clinical JJ cord-015365-iqdi99pd 567 7 and and CC cord-015365-iqdi99pd 567 8 genomic genomic JJ cord-015365-iqdi99pd 567 9 risk risk NN cord-015365-iqdi99pd 567 10 factors factor NNS cord-015365-iqdi99pd 567 11 for for IN cord-015365-iqdi99pd 567 12 ARI ARI NNP cord-015365-iqdi99pd 567 13 / / SYM cord-015365-iqdi99pd 567 14 ARF ARF NNP cord-015365-iqdi99pd 567 15 confirmed confirm VBD cord-015365-iqdi99pd 567 16 a a DT cord-015365-iqdi99pd 567 17 link link NN cord-015365-iqdi99pd 567 18 between between IN cord-015365-iqdi99pd 567 19 the the DT cord-015365-iqdi99pd 567 20 KIR KIR NNP cord-015365-iqdi99pd 567 21 haplotype haplotype NN cord-015365-iqdi99pd 567 22 A A NNP cord-015365-iqdi99pd 567 23 / / SYM cord-015365-iqdi99pd 567 24 A a NN cord-015365-iqdi99pd 567 25 and and CC cord-015365-iqdi99pd 567 26 post post JJ cord-015365-iqdi99pd 567 27 - - JJ cord-015365-iqdi99pd 567 28 LT lt NN cord-015365-iqdi99pd 567 29 acute acute JJ cord-015365-iqdi99pd 567 30 renal renal JJ cord-015365-iqdi99pd 567 31 failure failure NN cord-015365-iqdi99pd 567 32 ( ( -LRB- cord-015365-iqdi99pd 567 33 p p NN cord-015365-iqdi99pd 567 34 ¼ ¼ CD cord-015365-iqdi99pd 567 35 0.04 0.04 CD cord-015365-iqdi99pd 567 36 ) ) -RRB- cord-015365-iqdi99pd 567 37 . . . cord-015365-iqdi99pd 568 1 In in IN cord-015365-iqdi99pd 568 2 summary summary NN cord-015365-iqdi99pd 568 3 , , , cord-015365-iqdi99pd 568 4 we -PRON- PRP cord-015365-iqdi99pd 568 5 observed observe VBD cord-015365-iqdi99pd 568 6 a a DT cord-015365-iqdi99pd 568 7 higher high JJR cord-015365-iqdi99pd 568 8 percentage percentage NN cord-015365-iqdi99pd 568 9 of of IN cord-015365-iqdi99pd 568 10 NK NK NNP cord-015365-iqdi99pd 568 11 cells cell NNS cord-015365-iqdi99pd 568 12 prior prior RB cord-015365-iqdi99pd 568 13 to to IN cord-015365-iqdi99pd 568 14 LT LT NNP cord-015365-iqdi99pd 568 15 in in IN cord-015365-iqdi99pd 568 16 patients patient NNS cord-015365-iqdi99pd 568 17 with with IN cord-015365-iqdi99pd 568 18 impaired impaired JJ cord-015365-iqdi99pd 568 19 renal renal JJ cord-015365-iqdi99pd 568 20 function function NN cord-015365-iqdi99pd 568 21 and and CC cord-015365-iqdi99pd 568 22 identified identify VBD cord-015365-iqdi99pd 568 23 the the DT cord-015365-iqdi99pd 568 24 KIR KIR NNP cord-015365-iqdi99pd 568 25 haplotype haplotype NN cord-015365-iqdi99pd 568 26 A/ A/ NNP cord-015365-iqdi99pd 568 27 A A NNP cord-015365-iqdi99pd 568 28 as as IN cord-015365-iqdi99pd 568 29 an an DT cord-015365-iqdi99pd 568 30 independent independent JJ cord-015365-iqdi99pd 568 31 genetic genetic JJ cord-015365-iqdi99pd 568 32 risk risk NN cord-015365-iqdi99pd 568 33 factor factor NN cord-015365-iqdi99pd 568 34 for for IN cord-015365-iqdi99pd 568 35 ARF arf NN cord-015365-iqdi99pd 568 36 within within IN cord-015365-iqdi99pd 568 37 the the DT cord-015365-iqdi99pd 568 38 first first JJ cord-015365-iqdi99pd 568 39 postoperative postoperative JJ cord-015365-iqdi99pd 568 40 week week NN cord-015365-iqdi99pd 568 41 . . . cord-015365-iqdi99pd 569 1 Our -PRON- PRP$ cord-015365-iqdi99pd 569 2 data datum NNS cord-015365-iqdi99pd 569 3 provide provide VBP cord-015365-iqdi99pd 569 4 new new JJ cord-015365-iqdi99pd 569 5 aspects aspect NNS cord-015365-iqdi99pd 569 6 of of IN cord-015365-iqdi99pd 569 7 an an DT cord-015365-iqdi99pd 569 8 innate innate JJ cord-015365-iqdi99pd 569 9 immune immune JJ cord-015365-iqdi99pd 569 10 response response NN cord-015365-iqdi99pd 569 11 within within IN cord-015365-iqdi99pd 569 12 the the DT cord-015365-iqdi99pd 569 13 setting setting NN cord-015365-iqdi99pd 569 14 of of IN cord-015365-iqdi99pd 569 15 post post JJ cord-015365-iqdi99pd 569 16 - - JJ cord-015365-iqdi99pd 569 17 LT LT NNP cord-015365-iqdi99pd 569 18 kidney kidney NN cord-015365-iqdi99pd 569 19 injury injury NN cord-015365-iqdi99pd 569 20 and and CC cord-015365-iqdi99pd 569 21 failure failure NN cord-015365-iqdi99pd 569 22 . . . cord-015365-iqdi99pd 570 1 Background background NN cord-015365-iqdi99pd 570 2 . . . cord-015365-iqdi99pd 571 1 New new JJ cord-015365-iqdi99pd 571 2 - - HYPH cord-015365-iqdi99pd 571 3 onset onset JJ cord-015365-iqdi99pd 571 4 diabetes diabetes NN cord-015365-iqdi99pd 571 5 after after IN cord-015365-iqdi99pd 571 6 transplantation transplantation NN cord-015365-iqdi99pd 571 7 ( ( -LRB- cord-015365-iqdi99pd 571 8 NODAT NODAT NNP cord-015365-iqdi99pd 571 9 ) ) -RRB- cord-015365-iqdi99pd 571 10 is be VBZ cord-015365-iqdi99pd 571 11 a a DT cord-015365-iqdi99pd 571 12 serious serious JJ cord-015365-iqdi99pd 571 13 complication complication NN cord-015365-iqdi99pd 571 14 after after IN cord-015365-iqdi99pd 571 15 kidney kidney NN cord-015365-iqdi99pd 571 16 transplantation transplantation NN cord-015365-iqdi99pd 571 17 affecting affect VBG cord-015365-iqdi99pd 571 18 graft graft NN cord-015365-iqdi99pd 571 19 and and CC cord-015365-iqdi99pd 571 20 patient patient JJ cord-015365-iqdi99pd 571 21 survival survival NN cord-015365-iqdi99pd 571 22 . . . cord-015365-iqdi99pd 572 1 Currently currently RB cord-015365-iqdi99pd 572 2 , , , cord-015365-iqdi99pd 572 3 no no DT cord-015365-iqdi99pd 572 4 guidelines guideline NNS cord-015365-iqdi99pd 572 5 exist exist VBP cord-015365-iqdi99pd 572 6 about about IN cord-015365-iqdi99pd 572 7 the the DT cord-015365-iqdi99pd 572 8 ideal ideal JJ cord-015365-iqdi99pd 572 9 management management NN cord-015365-iqdi99pd 572 10 of of IN cord-015365-iqdi99pd 572 11 renal renal JJ cord-015365-iqdi99pd 572 12 transplant transplant NN cord-015365-iqdi99pd 572 13 patients patient NNS cord-015365-iqdi99pd 572 14 with with IN cord-015365-iqdi99pd 572 15 impaired impaired JJ cord-015365-iqdi99pd 572 16 glucose glucose NN cord-015365-iqdi99pd 572 17 tolerance tolerance NN cord-015365-iqdi99pd 572 18 ( ( -LRB- cord-015365-iqdi99pd 572 19 IGT IGT NNP cord-015365-iqdi99pd 572 20 , , , cord-015365-iqdi99pd 572 21 blood blood NN cord-015365-iqdi99pd 572 22 glucose glucose NN cord-015365-iqdi99pd 573 1 > > XX cord-015365-iqdi99pd 574 1 140 140 CD cord-015365-iqdi99pd 574 2 and and CC cord-015365-iqdi99pd 574 3 < < XX cord-015365-iqdi99pd 574 4 200 200 CD cord-015365-iqdi99pd 574 5 mg mg NNP cord-015365-iqdi99pd 574 6 / / SYM cord-015365-iqdi99pd 574 7 dl dl NNP cord-015365-iqdi99pd 574 8 ) ) -RRB- cord-015365-iqdi99pd 574 9 who who WP cord-015365-iqdi99pd 574 10 are be VBP cord-015365-iqdi99pd 574 11 at at IN cord-015365-iqdi99pd 574 12 highest high JJS cord-015365-iqdi99pd 574 13 risk risk NN cord-015365-iqdi99pd 574 14 for for IN cord-015365-iqdi99pd 574 15 developing develop VBG cord-015365-iqdi99pd 574 16 manifest manifest JJ cord-015365-iqdi99pd 574 17 diabetes diabete NNS cord-015365-iqdi99pd 574 18 . . . cord-015365-iqdi99pd 575 1 Here here RB cord-015365-iqdi99pd 575 2 , , , cord-015365-iqdi99pd 575 3 we -PRON- PRP cord-015365-iqdi99pd 575 4 studied study VBD cord-015365-iqdi99pd 575 5 the the DT cord-015365-iqdi99pd 575 6 efficacy efficacy NN cord-015365-iqdi99pd 575 7 and and CC cord-015365-iqdi99pd 575 8 safety safety NN cord-015365-iqdi99pd 575 9 of of IN cord-015365-iqdi99pd 575 10 vildagliptin vildagliptin NN cord-015365-iqdi99pd 575 11 and and CC cord-015365-iqdi99pd 575 12 pioglitazone pioglitazone NN cord-015365-iqdi99pd 575 13 in in IN cord-015365-iqdi99pd 575 14 patients patient NNS cord-015365-iqdi99pd 575 15 with with IN cord-015365-iqdi99pd 575 16 IGT IGT NNP cord-015365-iqdi99pd 575 17 after after IN cord-015365-iqdi99pd 575 18 renal renal JJ cord-015365-iqdi99pd 575 19 transplantation transplantation NN cord-015365-iqdi99pd 575 20 . . . cord-015365-iqdi99pd 576 1 Methods method NNS cord-015365-iqdi99pd 576 2 . . . cord-015365-iqdi99pd 577 1 After after IN cord-015365-iqdi99pd 577 2 routine routine JJ cord-015365-iqdi99pd 577 3 oral oral JJ cord-015365-iqdi99pd 577 4 glucose glucose NN cord-015365-iqdi99pd 577 5 tolerance tolerance NN cord-015365-iqdi99pd 577 6 testing testing NN cord-015365-iqdi99pd 577 7 ( ( -LRB- cord-015365-iqdi99pd 577 8 OGTT OGTT NNP cord-015365-iqdi99pd 577 9 ) ) -RRB- cord-015365-iqdi99pd 577 10 in in IN cord-015365-iqdi99pd 577 11 our -PRON- PRP$ cord-015365-iqdi99pd 577 12 center center NN cord-015365-iqdi99pd 577 13 , , , cord-015365-iqdi99pd 577 14 48 48 CD cord-015365-iqdi99pd 577 15 stable stable JJ cord-015365-iqdi99pd 577 16 renal renal JJ cord-015365-iqdi99pd 577 17 transplant transplant NN cord-015365-iqdi99pd 577 18 patients patient NNS cord-015365-iqdi99pd 577 19 with with IN cord-015365-iqdi99pd 577 20 IGT IGT NNP cord-015365-iqdi99pd 577 21 were be VBD cord-015365-iqdi99pd 577 22 recruited recruit VBN cord-015365-iqdi99pd 577 23 in in IN cord-015365-iqdi99pd 577 24 this this DT cord-015365-iqdi99pd 577 25 double double JJ cord-015365-iqdi99pd 577 26 blind blind JJ cord-015365-iqdi99pd 577 27 , , , cord-015365-iqdi99pd 577 28 prospective prospective JJ cord-015365-iqdi99pd 577 29 study study NN cord-015365-iqdi99pd 577 30 and and CC cord-015365-iqdi99pd 577 31 randomized randomized JJ cord-015365-iqdi99pd 577 32 1 1 CD cord-015365-iqdi99pd 577 33 : : SYM cord-015365-iqdi99pd 577 34 1 1 CD cord-015365-iqdi99pd 577 35 : : SYM cord-015365-iqdi99pd 577 36 1 1 CD cord-015365-iqdi99pd 577 37 to to TO cord-015365-iqdi99pd 577 38 receive receive VB cord-015365-iqdi99pd 577 39 either either CC cord-015365-iqdi99pd 577 40 50 50 CD cord-015365-iqdi99pd 577 41 mg mg NNP cord-015365-iqdi99pd 577 42 vildagliptin vildagliptin NNP cord-015365-iqdi99pd 577 43 , , , cord-015365-iqdi99pd 577 44 30 30 CD cord-015365-iqdi99pd 577 45 mg mg NN cord-015365-iqdi99pd 577 46 pioglitazone pioglitazone NN cord-015365-iqdi99pd 577 47 or or CC cord-015365-iqdi99pd 577 48 placebo placebo NN cord-015365-iqdi99pd 577 49 once once RB cord-015365-iqdi99pd 577 50 daily daily RB cord-015365-iqdi99pd 577 51 for for IN cord-015365-iqdi99pd 577 52 3 3 CD cord-015365-iqdi99pd 577 53 months month NNS cord-015365-iqdi99pd 577 54 . . . cord-015365-iqdi99pd 578 1 After after IN cord-015365-iqdi99pd 578 2 treatment treatment NN cord-015365-iqdi99pd 578 3 OGTTs ogtt NNS cord-015365-iqdi99pd 578 4 were be VBD cord-015365-iqdi99pd 578 5 performed perform VBN cord-015365-iqdi99pd 578 6 and and CC cord-015365-iqdi99pd 578 7 HbA1c HbA1c NNP cord-015365-iqdi99pd 578 8 levels level NNS cord-015365-iqdi99pd 578 9 along along IN cord-015365-iqdi99pd 578 10 with with IN cord-015365-iqdi99pd 578 11 body body NN cord-015365-iqdi99pd 578 12 mass mass NN cord-015365-iqdi99pd 578 13 index index NN cord-015365-iqdi99pd 578 14 ( ( -LRB- cord-015365-iqdi99pd 578 15 BMI BMI NNP cord-015365-iqdi99pd 578 16 ) ) -RRB- cord-015365-iqdi99pd 578 17 , , , cord-015365-iqdi99pd 578 18 metabolic metabolic JJ cord-015365-iqdi99pd 578 19 and and CC cord-015365-iqdi99pd 578 20 safety safety NN cord-015365-iqdi99pd 578 21 parameters parameter NNS cord-015365-iqdi99pd 578 22 were be VBD cord-015365-iqdi99pd 578 23 evaluated evaluate VBN cord-015365-iqdi99pd 578 24 . . . cord-015365-iqdi99pd 579 1 Results result NNS cord-015365-iqdi99pd 579 2 . . . cord-015365-iqdi99pd 580 1 So so RB cord-015365-iqdi99pd 580 2 far far RB cord-015365-iqdi99pd 580 3 45 45 CD cord-015365-iqdi99pd 580 4 patients patient NNS cord-015365-iqdi99pd 580 5 have have VBP cord-015365-iqdi99pd 580 6 finished finish VBN cord-015365-iqdi99pd 580 7 the the DT cord-015365-iqdi99pd 580 8 study study NN cord-015365-iqdi99pd 580 9 . . . cord-015365-iqdi99pd 581 1 2 2 CD cord-015365-iqdi99pd 581 2 hour hour NN cord-015365-iqdi99pd 581 3 glucose glucose NN cord-015365-iqdi99pd 581 4 values value NNS cord-015365-iqdi99pd 581 5 improved improve VBN cord-015365-iqdi99pd 581 6 in in IN cord-015365-iqdi99pd 581 7 all all DT cord-015365-iqdi99pd 581 8 three three CD cord-015365-iqdi99pd 581 9 groups group NNS cord-015365-iqdi99pd 581 10 with with IN cord-015365-iqdi99pd 581 11 the the DT cord-015365-iqdi99pd 581 12 greatest great JJS cord-015365-iqdi99pd 581 13 mean mean JJ cord-015365-iqdi99pd 581 14 improvement improvement NN cord-015365-iqdi99pd 581 15 in in IN cord-015365-iqdi99pd 581 16 the the DT cord-015365-iqdi99pd 581 17 pioglitazone pioglitazone NN cord-015365-iqdi99pd 581 18 group group NN cord-015365-iqdi99pd 581 19 . . . cord-015365-iqdi99pd 582 1 Fasting fast VBG cord-015365-iqdi99pd 582 2 glucose glucose NN cord-015365-iqdi99pd 582 3 values value NNS cord-015365-iqdi99pd 582 4 also also RB cord-015365-iqdi99pd 582 5 showed show VBD cord-015365-iqdi99pd 582 6 the the DT cord-015365-iqdi99pd 582 7 strongest strong JJS cord-015365-iqdi99pd 582 8 improvement improvement NN cord-015365-iqdi99pd 582 9 in in IN cord-015365-iqdi99pd 582 10 the the DT cord-015365-iqdi99pd 582 11 pioglitazone pioglitazone NN cord-015365-iqdi99pd 582 12 group group NN cord-015365-iqdi99pd 582 13 as as RB cord-015365-iqdi99pd 582 14 well well RB cord-015365-iqdi99pd 582 15 as as IN cord-015365-iqdi99pd 582 16 HbA1c HbA1c NNP cord-015365-iqdi99pd 582 17 ( ( -LRB- cord-015365-iqdi99pd 582 18 vildagliptin vildagliptin NNP cord-015365-iqdi99pd 582 19 : : : cord-015365-iqdi99pd 582 20 0.079 0.079 CD cord-015365-iqdi99pd 582 21 % % NN cord-015365-iqdi99pd 582 22 AE AE NNP cord-015365-iqdi99pd 582 23 0.249 0.249 CD cord-015365-iqdi99pd 582 24 % % NN cord-015365-iqdi99pd 582 25 , , , cord-015365-iqdi99pd 582 26 pioglitazone pioglitazone NN cord-015365-iqdi99pd 582 27 : : : cord-015365-iqdi99pd 582 28 À0.153 à0.153 CD cord-015365-iqdi99pd 582 29 % % NN cord-015365-iqdi99pd 582 30 AE AE NNP cord-015365-iqdi99pd 582 31 0.318 0.318 CD cord-015365-iqdi99pd 582 32 % % NN cord-015365-iqdi99pd 582 33 , , , cord-015365-iqdi99pd 582 34 placebo placebo NN cord-015365-iqdi99pd 582 35 : : : cord-015365-iqdi99pd 582 36 þ0.056 þ0.056 NNP cord-015365-iqdi99pd 582 37 % % NN cord-015365-iqdi99pd 582 38 AE AE NNP cord-015365-iqdi99pd 582 39 0.294 0.294 CD cord-015365-iqdi99pd 582 40 % % NN cord-015365-iqdi99pd 582 41 ) ) -RRB- cord-015365-iqdi99pd 582 42 . . . cord-015365-iqdi99pd 583 1 BMI BMI NNP cord-015365-iqdi99pd 583 2 increased increase VBD cord-015365-iqdi99pd 583 3 in in IN cord-015365-iqdi99pd 583 4 the the DT cord-015365-iqdi99pd 583 5 pioglitazone pioglitazone NN cord-015365-iqdi99pd 583 6 group group NN cord-015365-iqdi99pd 583 7 and and CC cord-015365-iqdi99pd 583 8 decreased decrease VBD cord-015365-iqdi99pd 583 9 in in IN cord-015365-iqdi99pd 583 10 the the DT cord-015365-iqdi99pd 583 11 vildagliptin vildagliptin NN cord-015365-iqdi99pd 583 12 and and CC cord-015365-iqdi99pd 583 13 placebo placebo NN cord-015365-iqdi99pd 583 14 group group NN cord-015365-iqdi99pd 583 15 . . . cord-015365-iqdi99pd 584 1 The the DT cord-015365-iqdi99pd 584 2 difference difference NN cord-015365-iqdi99pd 584 3 in in IN cord-015365-iqdi99pd 584 4 HbA1c hba1c NN cord-015365-iqdi99pd 584 5 between between IN cord-015365-iqdi99pd 584 6 pioglitazone pioglitazone NN cord-015365-iqdi99pd 584 7 and and CC cord-015365-iqdi99pd 584 8 placebo placebo NN cord-015365-iqdi99pd 584 9 reached reach VBD cord-015365-iqdi99pd 584 10 marginal marginal JJ cord-015365-iqdi99pd 584 11 statistical statistical JJ cord-015365-iqdi99pd 584 12 significance significance NN cord-015365-iqdi99pd 584 13 at at IN cord-015365-iqdi99pd 584 14 p p NN cord-015365-iqdi99pd 584 15 ¼ ¼ CD cord-015365-iqdi99pd 584 16 0.05 0.05 CD cord-015365-iqdi99pd 584 17 . . . cord-015365-iqdi99pd 585 1 Safety safety NN cord-015365-iqdi99pd 585 2 analysis analysis NN cord-015365-iqdi99pd 585 3 showed show VBD cord-015365-iqdi99pd 585 4 no no DT cord-015365-iqdi99pd 585 5 significant significant JJ cord-015365-iqdi99pd 585 6 influences influence NNS cord-015365-iqdi99pd 585 7 on on IN cord-015365-iqdi99pd 585 8 glomerular glomerular JJ cord-015365-iqdi99pd 585 9 filtration filtration NN cord-015365-iqdi99pd 585 10 rate rate NN cord-015365-iqdi99pd 585 11 ( ( -LRB- cord-015365-iqdi99pd 585 12 GFR GFR NNP cord-015365-iqdi99pd 585 13 ) ) -RRB- cord-015365-iqdi99pd 585 14 . . . cord-015365-iqdi99pd 586 1 Pioglitazone pioglitazone NN cord-015365-iqdi99pd 586 2 led lead VBD cord-015365-iqdi99pd 586 3 to to IN cord-015365-iqdi99pd 586 4 significant significant JJ cord-015365-iqdi99pd 586 5 reductions reduction NNS cord-015365-iqdi99pd 586 6 in in IN cord-015365-iqdi99pd 586 7 GPT GPT NNP cord-015365-iqdi99pd 586 8 and and CC cord-015365-iqdi99pd 586 9 Gamma Gamma NNP cord-015365-iqdi99pd 586 10 - - HYPH cord-015365-iqdi99pd 586 11 GT GT NNP cord-015365-iqdi99pd 586 12 as as RB cord-015365-iqdi99pd 586 13 well well RB cord-015365-iqdi99pd 586 14 as as IN cord-015365-iqdi99pd 586 15 increases increase NNS cord-015365-iqdi99pd 586 16 in in IN cord-015365-iqdi99pd 586 17 HDL HDL NNP cord-015365-iqdi99pd 586 18 . . . cord-015365-iqdi99pd 587 1 Adverse adverse JJ cord-015365-iqdi99pd 587 2 events event NNS cord-015365-iqdi99pd 587 3 occurred occur VBD cord-015365-iqdi99pd 587 4 at at IN cord-015365-iqdi99pd 587 5 similar similar JJ cord-015365-iqdi99pd 587 6 rate rate NN cord-015365-iqdi99pd 587 7 in in IN cord-015365-iqdi99pd 587 8 all all DT cord-015365-iqdi99pd 587 9 three three CD cord-015365-iqdi99pd 587 10 groups group NNS cord-015365-iqdi99pd 587 11 and and CC cord-015365-iqdi99pd 587 12 were be VBD cord-015365-iqdi99pd 587 13 generally generally RB cord-015365-iqdi99pd 587 14 mild mild JJ cord-015365-iqdi99pd 587 15 and and CC cord-015365-iqdi99pd 587 16 reversible reversible JJ cord-015365-iqdi99pd 587 17 . . . cord-015365-iqdi99pd 588 1 Conclusions conclusion NNS cord-015365-iqdi99pd 588 2 . . . cord-015365-iqdi99pd 589 1 Vildagliptin Vildagliptin NNP cord-015365-iqdi99pd 589 2 and and CC cord-015365-iqdi99pd 589 3 pioglitazone pioglitazone NN cord-015365-iqdi99pd 589 4 are be VBP cord-015365-iqdi99pd 589 5 both both DT cord-015365-iqdi99pd 589 6 safe safe JJ cord-015365-iqdi99pd 589 7 and and CC cord-015365-iqdi99pd 589 8 effective effective JJ cord-015365-iqdi99pd 589 9 in in IN cord-015365-iqdi99pd 589 10 patients patient NNS cord-015365-iqdi99pd 589 11 after after IN cord-015365-iqdi99pd 589 12 renal renal JJ cord-015365-iqdi99pd 589 13 transplantation transplantation NN cord-015365-iqdi99pd 589 14 . . . cord-015365-iqdi99pd 590 1 However however RB cord-015365-iqdi99pd 590 2 , , , cord-015365-iqdi99pd 590 3 only only RB cord-015365-iqdi99pd 590 4 pioglitazone pioglitazone NN cord-015365-iqdi99pd 590 5 led lead VBD cord-015365-iqdi99pd 590 6 to to IN cord-015365-iqdi99pd 590 7 significant significant JJ cord-015365-iqdi99pd 590 8 improvements improvement NNS cord-015365-iqdi99pd 590 9 in in IN cord-015365-iqdi99pd 590 10 glycemic glycemic NN cord-015365-iqdi99pd 590 11 control control NN cord-015365-iqdi99pd 590 12 . . . cord-015365-iqdi99pd 591 1 Furthermore furthermore RB cord-015365-iqdi99pd 591 2 , , , cord-015365-iqdi99pd 591 3 pioglitazone pioglitazone NN cord-015365-iqdi99pd 591 4 led lead VBD cord-015365-iqdi99pd 591 5 to to IN cord-015365-iqdi99pd 591 6 improvements improvement NNS cord-015365-iqdi99pd 591 7 in in IN cord-015365-iqdi99pd 591 8 GFR GFR NNP cord-015365-iqdi99pd 591 9 and and CC cord-015365-iqdi99pd 591 10 lipid lipid NN cord-015365-iqdi99pd 591 11 metabolism metabolism NN cord-015365-iqdi99pd 591 12 besides besides IN cord-015365-iqdi99pd 591 13 causing cause VBG cord-015365-iqdi99pd 591 14 the the DT cord-015365-iqdi99pd 591 15 largest large JJS cord-015365-iqdi99pd 591 16 weight weight NN cord-015365-iqdi99pd 591 17 gain gain NN cord-015365-iqdi99pd 591 18 . . . cord-015365-iqdi99pd 592 1 While while IN cord-015365-iqdi99pd 592 2 further further JJ cord-015365-iqdi99pd 592 3 studies study NNS cord-015365-iqdi99pd 592 4 with with IN cord-015365-iqdi99pd 592 5 longer long JJR cord-015365-iqdi99pd 592 6 observation observation NN cord-015365-iqdi99pd 592 7 periods period NNS cord-015365-iqdi99pd 592 8 are be VBP cord-015365-iqdi99pd 592 9 urgently urgently RB cord-015365-iqdi99pd 592 10 required require VBN cord-015365-iqdi99pd 592 11 , , , cord-015365-iqdi99pd 592 12 pioglitazone pioglitazone NN cord-015365-iqdi99pd 592 13 seems seem VBZ cord-015365-iqdi99pd 592 14 to to TO cord-015365-iqdi99pd 592 15 possess possess VB cord-015365-iqdi99pd 592 16 efficient efficient JJ cord-015365-iqdi99pd 592 17 beta beta JJ cord-015365-iqdi99pd 592 18 - - HYPH cord-015365-iqdi99pd 592 19 cell cell NN cord-015365-iqdi99pd 592 20 protective protective JJ cord-015365-iqdi99pd 592 21 potency potency NN cord-015365-iqdi99pd 592 22 . . . cord-015365-iqdi99pd 593 1 Clinical clinical JJ cord-015365-iqdi99pd 593 2 relevance relevance NN cord-015365-iqdi99pd 593 3 of of IN cord-015365-iqdi99pd 593 4 preformed preformed JJ cord-015365-iqdi99pd 593 5 complement complement NN cord-015365-iqdi99pd 593 6 - - : cord-015365-iqdi99pd 593 7 and and CC cord-015365-iqdi99pd 593 8 non non JJ cord-015365-iqdi99pd 593 9 - - JJ cord-015365-iqdi99pd 593 10 complement complement JJ cord-015365-iqdi99pd 593 11 - - HYPH cord-015365-iqdi99pd 593 12 fixing fix VBG cord-015365-iqdi99pd 593 13 HLA HLA NNP cord-015365-iqdi99pd 593 14 alloreactivity alloreactivity NN cord-015365-iqdi99pd 593 15 in in IN cord-015365-iqdi99pd 593 16 cardiac cardiac JJ cord-015365-iqdi99pd 593 17 transplantation transplantation NN cord-015365-iqdi99pd 593 18 S. S. NNP cord-015365-iqdi99pd 593 19 Mahr Mahr NNP cord-015365-iqdi99pd 593 20 1 1 CD cord-015365-iqdi99pd 593 21 , , , cord-015365-iqdi99pd 593 22 M. M. NNP cord-015365-iqdi99pd 593 23 Wahrmann Wahrmann NNP cord-015365-iqdi99pd 593 24 2 2 CD cord-015365-iqdi99pd 593 25 , , , cord-015365-iqdi99pd 593 26 A. A. NNP cord-015365-iqdi99pd 593 27 Zuckermann Zuckermann NNP cord-015365-iqdi99pd 593 28 1 1 CD cord-015365-iqdi99pd 593 29 , , , cord-015365-iqdi99pd 593 30 G. G. NNP cord-015365-iqdi99pd 593 31 Böhmig Böhmig NNP cord-015365-iqdi99pd 593 32 2 2 CD cord-015365-iqdi99pd 593 33 Background Background NNP cord-015365-iqdi99pd 593 34 . . . cord-015365-iqdi99pd 594 1 There there EX cord-015365-iqdi99pd 594 2 is be VBZ cord-015365-iqdi99pd 594 3 increasing increase VBG cord-015365-iqdi99pd 594 4 evidence evidence NN cord-015365-iqdi99pd 594 5 for for IN cord-015365-iqdi99pd 594 6 a a DT cord-015365-iqdi99pd 594 7 role role NN cord-015365-iqdi99pd 594 8 of of IN cord-015365-iqdi99pd 594 9 alloantibody alloantibody NN cord-015365-iqdi99pd 594 10 - - HYPH cord-015365-iqdi99pd 594 11 mediated mediate VBN cord-015365-iqdi99pd 594 12 rejection rejection NN cord-015365-iqdi99pd 594 13 in in IN cord-015365-iqdi99pd 594 14 organ organ NN cord-015365-iqdi99pd 594 15 transplantation transplantation NN cord-015365-iqdi99pd 594 16 . . . cord-015365-iqdi99pd 595 1 Solid solid JJ cord-015365-iqdi99pd 595 2 phase phase NN cord-015365-iqdi99pd 595 3 HLA HLA NNP cord-015365-iqdi99pd 595 4 antibody antibody NN cord-015365-iqdi99pd 595 5 detection detection NN cord-015365-iqdi99pd 595 6 using use VBG cord-015365-iqdi99pd 595 7 bead bead NN cord-015365-iqdi99pd 595 8 array array NN cord-015365-iqdi99pd 595 9 technology technology NN cord-015365-iqdi99pd 595 10 may may MD cord-015365-iqdi99pd 595 11 help help VB cord-015365-iqdi99pd 595 12 identify identify VB cord-015365-iqdi99pd 595 13 patients patient NNS cord-015365-iqdi99pd 595 14 at at IN cord-015365-iqdi99pd 595 15 risk risk NN cord-015365-iqdi99pd 595 16 of of IN cord-015365-iqdi99pd 595 17 rejection rejection NN cord-015365-iqdi99pd 595 18 and and CC cord-015365-iqdi99pd 595 19 graft graft NN cord-015365-iqdi99pd 595 20 loss loss NN cord-015365-iqdi99pd 595 21 . . . cord-015365-iqdi99pd 596 1 Methods method NNS cord-015365-iqdi99pd 596 2 . . . cord-015365-iqdi99pd 597 1 In in IN cord-015365-iqdi99pd 597 2 this this DT cord-015365-iqdi99pd 597 3 retrospective retrospective JJ cord-015365-iqdi99pd 597 4 monocentric monocentric JJ cord-015365-iqdi99pd 597 5 cohort cohort NN cord-015365-iqdi99pd 597 6 study study NN cord-015365-iqdi99pd 597 7 we -PRON- PRP cord-015365-iqdi99pd 597 8 evaluated evaluate VBD cord-015365-iqdi99pd 597 9 229 229 CD cord-015365-iqdi99pd 597 10 consecutive consecutive JJ cord-015365-iqdi99pd 597 11 heart heart NN cord-015365-iqdi99pd 597 12 transplant transplant NN cord-015365-iqdi99pd 597 13 recipients recipient NNS cord-015365-iqdi99pd 597 14 ( ( -LRB- cord-015365-iqdi99pd 597 15 transplantation transplantation NN cord-015365-iqdi99pd 597 16 between between IN cord-015365-iqdi99pd 597 17 2000 2000 CD cord-015365-iqdi99pd 597 18 and and CC cord-015365-iqdi99pd 597 19 2006 2006 CD cord-015365-iqdi99pd 597 20 ; ; : cord-015365-iqdi99pd 597 21 immunosuppression immunosuppression NN cord-015365-iqdi99pd 597 22 : : : cord-015365-iqdi99pd 597 23 ATG ATG NNP cord-015365-iqdi99pd 597 24 induction induction NN cord-015365-iqdi99pd 597 25 and and CC cord-015365-iqdi99pd 597 26 calcineurin calcineurin JJ cord-015365-iqdi99pd 597 27 inhibitor inhibitor NN cord-015365-iqdi99pd 597 28 - - HYPH cord-015365-iqdi99pd 597 29 based base VBN cord-015365-iqdi99pd 597 30 maintenance maintenance NN cord-015365-iqdi99pd 597 31 therapy therapy NN cord-015365-iqdi99pd 597 32 ) ) -RRB- cord-015365-iqdi99pd 597 33 for for IN cord-015365-iqdi99pd 597 34 the the DT cord-015365-iqdi99pd 597 35 presence presence NN cord-015365-iqdi99pd 597 36 of of IN cord-015365-iqdi99pd 597 37 preformed preformed JJ cord-015365-iqdi99pd 597 38 ( ( -LRB- cord-015365-iqdi99pd 597 39 complement complement NN cord-015365-iqdi99pd 597 40 - - : cord-015365-iqdi99pd 597 41 and and CC cord-015365-iqdi99pd 597 42 non non JJ cord-015365-iqdi99pd 597 43 - - JJ cord-015365-iqdi99pd 597 44 complement complement NN cord-015365-iqdi99pd 597 45 - - HYPH cord-015365-iqdi99pd 597 46 fixing fix VBG cord-015365-iqdi99pd 597 47 ) ) -RRB- cord-015365-iqdi99pd 597 48 HLA HLA NNP cord-015365-iqdi99pd 597 49 alloantibodies alloantibody NNS cord-015365-iqdi99pd 597 50 . . . cord-015365-iqdi99pd 598 1 Sera Sera NNP cord-015365-iqdi99pd 598 2 obtained obtain VBD cord-015365-iqdi99pd 598 3 immediately immediately RB cord-015365-iqdi99pd 598 4 before before IN cord-015365-iqdi99pd 598 5 transplantation transplantation NN cord-015365-iqdi99pd 598 6 were be VBD cord-015365-iqdi99pd 598 7 screened screen VBN cord-015365-iqdi99pd 598 8 by by IN cord-015365-iqdi99pd 598 9 FlowPRA FlowPRA NNP cord-015365-iqdi99pd 598 10 , , , cord-015365-iqdi99pd 598 11 and and CC cord-015365-iqdi99pd 598 12 test test NN cord-015365-iqdi99pd 598 13 - - HYPH cord-015365-iqdi99pd 598 14 positive positive JJ cord-015365-iqdi99pd 598 15 sera sera NNP cord-015365-iqdi99pd 598 16 were be VBD cord-015365-iqdi99pd 598 17 subjected subject VBN cord-015365-iqdi99pd 598 18 to to IN cord-015365-iqdi99pd 598 19 Luminex Luminex NNP cord-015365-iqdi99pd 598 20 - - HYPH cord-015365-iqdi99pd 598 21 based base VBN cord-015365-iqdi99pd 598 22 single single JJ cord-015365-iqdi99pd 598 23 antigen antigen NN cord-015365-iqdi99pd 598 24 testing testing NN cord-015365-iqdi99pd 598 25 including include VBG cord-015365-iqdi99pd 598 26 a a DT cord-015365-iqdi99pd 598 27 test test NN cord-015365-iqdi99pd 598 28 modification modification NN cord-015365-iqdi99pd 598 29 for for IN cord-015365-iqdi99pd 598 30 detection detection NN cord-015365-iqdi99pd 598 31 of of IN cord-015365-iqdi99pd 598 32 in in IN cord-015365-iqdi99pd 598 33 vitro vitro FW cord-015365-iqdi99pd 598 34 C4d C4d NNP cord-015365-iqdi99pd 598 35 deposition deposition NN cord-015365-iqdi99pd 598 36 . . . cord-015365-iqdi99pd 599 1 Results result NNS cord-015365-iqdi99pd 599 2 . . . cord-015365-iqdi99pd 600 1 Seventeen seventeen CD cord-015365-iqdi99pd 600 2 recipients recipient NNS cord-015365-iqdi99pd 600 3 ( ( -LRB- cord-015365-iqdi99pd 600 4 7.3 7.3 CD cord-015365-iqdi99pd 600 5 % % NN cord-015365-iqdi99pd 600 6 ) ) -RRB- cord-015365-iqdi99pd 600 7 were be VBD cord-015365-iqdi99pd 600 8 found find VBN cord-015365-iqdi99pd 600 9 to to TO cord-015365-iqdi99pd 600 10 have have VB cord-015365-iqdi99pd 600 11 preformed preform VBN cord-015365-iqdi99pd 600 12 IgG igg NN cord-015365-iqdi99pd 600 13 type type NN cord-015365-iqdi99pd 600 14 donor donor NN cord-015365-iqdi99pd 600 15 - - HYPH cord-015365-iqdi99pd 600 16 specific specific JJ cord-015365-iqdi99pd 600 17 alloantibodies alloantibody NNS cord-015365-iqdi99pd 600 18 ( ( -LRB- cord-015365-iqdi99pd 600 19 DSA DSA NNP cord-015365-iqdi99pd 600 20 ) ) -RRB- cord-015365-iqdi99pd 600 21 , , , cord-015365-iqdi99pd 600 22 five five CD cord-015365-iqdi99pd 600 23 of of IN cord-015365-iqdi99pd 600 24 them -PRON- PRP cord-015365-iqdi99pd 600 25 with with IN cord-015365-iqdi99pd 600 26 C4d C4d NNP cord-015365-iqdi99pd 600 27 - - HYPH cord-015365-iqdi99pd 600 28 fixing fix VBG cord-015365-iqdi99pd 600 29 capability capability NN cord-015365-iqdi99pd 600 30 . . . cord-015365-iqdi99pd 601 1 The the DT cord-015365-iqdi99pd 601 2 presence presence NN cord-015365-iqdi99pd 601 3 of of IN cord-015365-iqdi99pd 601 4 DSA DSA NNP cord-015365-iqdi99pd 601 5 was be VBD cord-015365-iqdi99pd 601 6 related relate VBN cord-015365-iqdi99pd 601 7 to to IN cord-015365-iqdi99pd 601 8 retransplantation retransplantation NN cord-015365-iqdi99pd 601 9 and and CC cord-015365-iqdi99pd 601 10 previous previous JJ cord-015365-iqdi99pd 601 11 pregnancies pregnancy NNS cord-015365-iqdi99pd 601 12 , , , cord-015365-iqdi99pd 601 13 but but CC cord-015365-iqdi99pd 601 14 not not RB cord-015365-iqdi99pd 601 15 associated associate VBN cord-015365-iqdi99pd 601 16 with with IN cord-015365-iqdi99pd 601 17 prior prior JJ cord-015365-iqdi99pd 601 18 implantation implantation NN cord-015365-iqdi99pd 601 19 of of IN cord-015365-iqdi99pd 601 20 a a DT cord-015365-iqdi99pd 601 21 ventricular ventricular JJ cord-015365-iqdi99pd 601 22 assist assist NN cord-015365-iqdi99pd 601 23 device device NN cord-015365-iqdi99pd 601 24 . . . cord-015365-iqdi99pd 602 1 Evaluating evaluate VBG cord-015365-iqdi99pd 602 2 clinical clinical JJ cord-015365-iqdi99pd 602 3 endpoints endpoint NNS cord-015365-iqdi99pd 602 4 , , , cord-015365-iqdi99pd 602 5 we -PRON- PRP cord-015365-iqdi99pd 602 6 found find VBD cord-015365-iqdi99pd 602 7 an an DT cord-015365-iqdi99pd 602 8 association association NN cord-015365-iqdi99pd 602 9 between between IN cord-015365-iqdi99pd 602 10 DSA DSA NNP cord-015365-iqdi99pd 602 11 and and CC cord-015365-iqdi99pd 602 12 acute acute JJ cord-015365-iqdi99pd 602 13 rejection rejection NN cord-015365-iqdi99pd 602 14 ( ( -LRB- cord-015365-iqdi99pd 602 15 > > NFP cord-015365-iqdi99pd 602 16 grade grade NN cord-015365-iqdi99pd 602 17 1A 1a NN cord-015365-iqdi99pd 602 18 according accord VBG cord-015365-iqdi99pd 602 19 to to IN cord-015365-iqdi99pd 602 20 the the DT cord-015365-iqdi99pd 602 21 ISHLT ISHLT NNP cord-015365-iqdi99pd 602 22 1990 1990 CD cord-015365-iqdi99pd 602 23 grading grading NN cord-015365-iqdi99pd 602 24 system system NN cord-015365-iqdi99pd 602 25 ; ; : cord-015365-iqdi99pd 602 26 no no DT cord-015365-iqdi99pd 602 27 DSA DSA NNP cord-015365-iqdi99pd 602 28 : : : cord-015365-iqdi99pd 602 29 17 17 CD cord-015365-iqdi99pd 602 30 % % NN cord-015365-iqdi99pd 602 31 ; ; , cord-015365-iqdi99pd 602 32 [ [ -LRB- cord-015365-iqdi99pd 602 33 IgG]DSA igg]dsa NN cord-015365-iqdi99pd 602 34 : : : cord-015365-iqdi99pd 602 35 33 33 CD cord-015365-iqdi99pd 602 36 % % NN cord-015365-iqdi99pd 602 37 ; ; . cord-015365-iqdi99pd 603 1 [ [ -LRB- cord-015365-iqdi99pd 603 2 IgG IgG NNP cord-015365-iqdi99pd 603 3 / / SYM cord-015365-iqdi99pd 603 4 C4d C4d NNP cord-015365-iqdi99pd 603 5 ] ] -RRB- cord-015365-iqdi99pd 603 6 DSA DSA NNP cord-015365-iqdi99pd 603 7 : : : cord-015365-iqdi99pd 603 8 60 60 CD cord-015365-iqdi99pd 603 9 % % NN cord-015365-iqdi99pd 603 10 ) ) -RRB- cord-015365-iqdi99pd 603 11 . . . cord-015365-iqdi99pd 604 1 However however RB cord-015365-iqdi99pd 604 2 , , , cord-015365-iqdi99pd 604 3 in in IN cord-015365-iqdi99pd 604 4 our -PRON- PRP$ cord-015365-iqdi99pd 604 5 study study NN cord-015365-iqdi99pd 604 6 cohort cohort NN cord-015365-iqdi99pd 604 7 , , , cord-015365-iqdi99pd 604 8 sensitization sensitization NN cord-015365-iqdi99pd 604 9 had have VBD cord-015365-iqdi99pd 604 10 no no DT cord-015365-iqdi99pd 604 11 effect effect NN cord-015365-iqdi99pd 604 12 on on IN cord-015365-iqdi99pd 604 13 long long JJ cord-015365-iqdi99pd 604 14 - - HYPH cord-015365-iqdi99pd 604 15 term term NN cord-015365-iqdi99pd 604 16 survival survival NN cord-015365-iqdi99pd 604 17 rates rate NNS cord-015365-iqdi99pd 604 18 ( ( -LRB- cord-015365-iqdi99pd 604 19 5-year 5-year CD cord-015365-iqdi99pd 604 20 transplant transplant NN cord-015365-iqdi99pd 604 21 survival survival NN cord-015365-iqdi99pd 604 22 : : : cord-015365-iqdi99pd 604 23 72 72 CD cord-015365-iqdi99pd 604 24 % % NN cord-015365-iqdi99pd 604 25 vs. vs. IN cord-015365-iqdi99pd 604 26 92 92 CD cord-015365-iqdi99pd 604 27 % % NN cord-015365-iqdi99pd 604 28 vs. vs. CC cord-015365-iqdi99pd 604 29 80 80 CD cord-015365-iqdi99pd 604 30 % % NN cord-015365-iqdi99pd 604 31 ) ) -RRB- cord-015365-iqdi99pd 604 32 or or CC cord-015365-iqdi99pd 604 33 rates rate NNS cord-015365-iqdi99pd 604 34 of of IN cord-015365-iqdi99pd 604 35 chronic chronic JJ cord-015365-iqdi99pd 604 36 transplant transplant NN cord-015365-iqdi99pd 604 37 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 604 38 ( ( -LRB- cord-015365-iqdi99pd 604 39 20 20 CD cord-015365-iqdi99pd 604 40 % % NN cord-015365-iqdi99pd 604 41 vs. vs. CC cord-015365-iqdi99pd 604 42 18 18 CD cord-015365-iqdi99pd 604 43 % % NN cord-015365-iqdi99pd 604 44 vs. vs. CC cord-015365-iqdi99pd 604 45 20 20 CD cord-015365-iqdi99pd 604 46 % % NN cord-015365-iqdi99pd 604 47 ) ) -RRB- cord-015365-iqdi99pd 604 48 . . . cord-015365-iqdi99pd 605 1 Moreover moreover RB cord-015365-iqdi99pd 605 2 , , , cord-015365-iqdi99pd 605 3 none none NN cord-015365-iqdi99pd 605 4 of of IN cord-015365-iqdi99pd 605 5 the the DT cord-015365-iqdi99pd 605 6 DSA DSA NNP cord-015365-iqdi99pd 605 7 - - HYPH cord-015365-iqdi99pd 605 8 positive positive JJ cord-015365-iqdi99pd 605 9 patients patient NNS cord-015365-iqdi99pd 605 10 was be VBD cord-015365-iqdi99pd 605 11 in in IN cord-015365-iqdi99pd 605 12 need need NN cord-015365-iqdi99pd 605 13 of of IN cord-015365-iqdi99pd 605 14 extracorporeal extracorporeal JJ cord-015365-iqdi99pd 605 15 membrane membrane NN cord-015365-iqdi99pd 605 16 oxygenation oxygenation NN cord-015365-iqdi99pd 605 17 , , , cord-015365-iqdi99pd 605 18 and and CC cord-015365-iqdi99pd 605 19 the the DT cord-015365-iqdi99pd 605 20 duration duration NN cord-015365-iqdi99pd 605 21 of of IN cord-015365-iqdi99pd 605 22 post post JJ cord-015365-iqdi99pd 605 23 - - JJ cord-015365-iqdi99pd 605 24 transplant transplant JJ cord-015365-iqdi99pd 605 25 intensive intensive JJ cord-015365-iqdi99pd 605 26 care care NN cord-015365-iqdi99pd 605 27 did do VBD cord-015365-iqdi99pd 605 28 not not RB cord-015365-iqdi99pd 605 29 differ differ VB cord-015365-iqdi99pd 605 30 between between IN cord-015365-iqdi99pd 605 31 groups group NNS cord-015365-iqdi99pd 605 32 . . . cord-015365-iqdi99pd 606 1 Conclusions conclusion NNS cord-015365-iqdi99pd 606 2 . . . cord-015365-iqdi99pd 607 1 In in IN cord-015365-iqdi99pd 607 2 conclusion conclusion NN cord-015365-iqdi99pd 607 3 , , , cord-015365-iqdi99pd 607 4 our -PRON- PRP$ cord-015365-iqdi99pd 607 5 data data NN cord-015365-iqdi99pd 607 6 point point NN cord-015365-iqdi99pd 607 7 to to IN cord-015365-iqdi99pd 607 8 a a DT cord-015365-iqdi99pd 607 9 relationship relationship NN cord-015365-iqdi99pd 607 10 between between IN cord-015365-iqdi99pd 607 11 preformed preformed JJ cord-015365-iqdi99pd 607 12 donor donor NN cord-015365-iqdi99pd 607 13 - - HYPH cord-015365-iqdi99pd 607 14 specific specific JJ cord-015365-iqdi99pd 607 15 alloreactivity alloreactivity NN cord-015365-iqdi99pd 607 16 and and CC cord-015365-iqdi99pd 607 17 acute acute JJ cord-015365-iqdi99pd 607 18 rejection rejection NN cord-015365-iqdi99pd 607 19 . . . cord-015365-iqdi99pd 608 1 However however RB cord-015365-iqdi99pd 608 2 , , , cord-015365-iqdi99pd 608 3 possibly possibly RB cord-015365-iqdi99pd 608 4 as as IN cord-015365-iqdi99pd 608 5 a a DT cord-015365-iqdi99pd 608 6 result result NN cord-015365-iqdi99pd 608 7 of of IN cord-015365-iqdi99pd 608 8 our -PRON- PRP$ cord-015365-iqdi99pd 608 9 local local JJ cord-015365-iqdi99pd 608 10 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 608 11 regimen regimen NN cord-015365-iqdi99pd 608 12 , , , cord-015365-iqdi99pd 608 13 which which WDT cord-015365-iqdi99pd 608 14 also also RB cord-015365-iqdi99pd 608 15 includes include VBZ cord-015365-iqdi99pd 608 16 induction induction NN cord-015365-iqdi99pd 608 17 therapy therapy NN cord-015365-iqdi99pd 608 18 with with IN cord-015365-iqdi99pd 608 19 a a DT cord-015365-iqdi99pd 608 20 depleting deplete VBG cord-015365-iqdi99pd 608 21 anti anti JJ cord-015365-iqdi99pd 608 22 - - JJ cord-015365-iqdi99pd 608 23 lymphocyte lymphocyte JJ cord-015365-iqdi99pd 608 24 antibody antibody NN cord-015365-iqdi99pd 608 25 , , , cord-015365-iqdi99pd 608 26 such such JJ cord-015365-iqdi99pd 608 27 reactivity reactivity NN cord-015365-iqdi99pd 608 28 did do VBD cord-015365-iqdi99pd 608 29 not not RB cord-015365-iqdi99pd 608 30 influence influence VB cord-015365-iqdi99pd 608 31 long long JJ cord-015365-iqdi99pd 608 32 - - HYPH cord-015365-iqdi99pd 608 33 term term NN cord-015365-iqdi99pd 608 34 allograft allograft NN cord-015365-iqdi99pd 608 35 outcomes outcome NNS cord-015365-iqdi99pd 608 36 . . . cord-015365-iqdi99pd 609 1 Background background NN cord-015365-iqdi99pd 609 2 . . . cord-015365-iqdi99pd 610 1 So so RB cord-015365-iqdi99pd 610 2 far far RB cord-015365-iqdi99pd 610 3 , , , cord-015365-iqdi99pd 610 4 no no DT cord-015365-iqdi99pd 610 5 data data NN cord-015365-iqdi99pd 610 6 is be VBZ cord-015365-iqdi99pd 610 7 available available JJ cord-015365-iqdi99pd 610 8 on on IN cord-015365-iqdi99pd 610 9 the the DT cord-015365-iqdi99pd 610 10 use use NN cord-015365-iqdi99pd 610 11 of of IN cord-015365-iqdi99pd 610 12 everolimus everolimus NN cord-015365-iqdi99pd 610 13 in in IN cord-015365-iqdi99pd 610 14 pediatric pediatric JJ cord-015365-iqdi99pd 610 15 cardiac cardiac JJ cord-015365-iqdi99pd 610 16 transplantation transplantation NN cord-015365-iqdi99pd 610 17 . . . cord-015365-iqdi99pd 611 1 We -PRON- PRP cord-015365-iqdi99pd 611 2 present present VBP cord-015365-iqdi99pd 611 3 the the DT cord-015365-iqdi99pd 611 4 first first JJ cord-015365-iqdi99pd 611 5 results result NNS cord-015365-iqdi99pd 611 6 of of IN cord-015365-iqdi99pd 611 7 everolimus everolimus NN cord-015365-iqdi99pd 611 8 in in IN cord-015365-iqdi99pd 611 9 pediatric pediatric JJ cord-015365-iqdi99pd 611 10 heart heart NN cord-015365-iqdi99pd 611 11 transplantation transplantation NN cord-015365-iqdi99pd 611 12 . . . cord-015365-iqdi99pd 612 1 Methods method NNS cord-015365-iqdi99pd 612 2 . . . cord-015365-iqdi99pd 613 1 From from IN cord-015365-iqdi99pd 613 2 2000 2000 CD cord-015365-iqdi99pd 613 3 to to IN cord-015365-iqdi99pd 613 4 2008 2008 CD cord-015365-iqdi99pd 613 5 , , , cord-015365-iqdi99pd 613 6 HTx HTx NNS cord-015365-iqdi99pd 613 7 was be VBD cord-015365-iqdi99pd 613 8 performed perform VBN cord-015365-iqdi99pd 613 9 in in IN cord-015365-iqdi99pd 613 10 86 86 CD cord-015365-iqdi99pd 613 11 children child NNS cord-015365-iqdi99pd 613 12 aged age VBN cord-015365-iqdi99pd 613 13 below below IN cord-015365-iqdi99pd 613 14 17 17 CD cord-015365-iqdi99pd 613 15 years year NNS cord-015365-iqdi99pd 613 16 . . . cord-015365-iqdi99pd 614 1 52 52 CD cord-015365-iqdi99pd 614 2 of of IN cord-015365-iqdi99pd 614 3 these these DT cord-015365-iqdi99pd 614 4 children child NNS cord-015365-iqdi99pd 614 5 received receive VBD cord-015365-iqdi99pd 614 6 continuously continuously RB cord-015365-iqdi99pd 614 7 either either CC cord-015365-iqdi99pd 614 8 mycophenolat mycophenolat NNP cord-015365-iqdi99pd 614 9 mofetil mofetil NNP cord-015365-iqdi99pd 614 10 ( ( -LRB- cord-015365-iqdi99pd 614 11 MMF MMF NNP cord-015365-iqdi99pd 614 12 ) ) -RRB- cord-015365-iqdi99pd 615 1 ( ( -LRB- cord-015365-iqdi99pd 615 2 Group Group NNP cord-015365-iqdi99pd 615 3 A A NNP cord-015365-iqdi99pd 615 4 , , , cord-015365-iqdi99pd 615 5 n n NN cord-015365-iqdi99pd 615 6 ¼ ¼ NNP cord-015365-iqdi99pd 615 7 28 28 CD cord-015365-iqdi99pd 615 8 ) ) -RRB- cord-015365-iqdi99pd 615 9 with with IN cord-015365-iqdi99pd 615 10 standard standard JJ cord-015365-iqdi99pd 615 11 cyclosporine cyclosporine NN cord-015365-iqdi99pd 615 12 A a NN cord-015365-iqdi99pd 615 13 ( ( -LRB- cord-015365-iqdi99pd 615 14 CsA CsA NNP cord-015365-iqdi99pd 615 15 ) ) -RRB- cord-015365-iqdi99pd 615 16 exposure exposure NN cord-015365-iqdi99pd 615 17 or or CC cord-015365-iqdi99pd 615 18 were be VBD cord-015365-iqdi99pd 615 19 randomized randomize VBN cord-015365-iqdi99pd 615 20 to to TO cord-015365-iqdi99pd 615 21 receive receive VB cord-015365-iqdi99pd 615 22 everolimus everolimus NNP cord-015365-iqdi99pd 615 23 ( ( -LRB- cord-015365-iqdi99pd 615 24 EVE EVE NNP cord-015365-iqdi99pd 615 25 ) ) -RRB- cord-015365-iqdi99pd 616 1 ( ( -LRB- cord-015365-iqdi99pd 616 2 Group Group NNP cord-015365-iqdi99pd 616 3 B B NNP cord-015365-iqdi99pd 616 4 , , , cord-015365-iqdi99pd 616 5 n n NN cord-015365-iqdi99pd 616 6 ¼ ¼ NNP cord-015365-iqdi99pd 616 7 24 24 CD cord-015365-iqdi99pd 616 8 ) ) -RRB- cord-015365-iqdi99pd 616 9 with with IN cord-015365-iqdi99pd 616 10 reduced reduce VBN cord-015365-iqdi99pd 616 11 CsA csa NN cord-015365-iqdi99pd 616 12 exposure exposure NN cord-015365-iqdi99pd 616 13 in in IN cord-015365-iqdi99pd 616 14 combination combination NN cord-015365-iqdi99pd 616 15 with with IN cord-015365-iqdi99pd 616 16 steroids steroid NNS cord-015365-iqdi99pd 616 17 . . . cord-015365-iqdi99pd 617 1 During during IN cord-015365-iqdi99pd 617 2 a a DT cord-015365-iqdi99pd 617 3 follow follow NN cord-015365-iqdi99pd 617 4 - - HYPH cord-015365-iqdi99pd 617 5 up up NN cord-015365-iqdi99pd 617 6 period period NN cord-015365-iqdi99pd 617 7 of of IN cord-015365-iqdi99pd 617 8 24 24 CD cord-015365-iqdi99pd 617 9 months month NNS cord-015365-iqdi99pd 617 10 , , , cord-015365-iqdi99pd 617 11 efficacy efficacy NN cord-015365-iqdi99pd 617 12 with with IN cord-015365-iqdi99pd 617 13 regard regard NN cord-015365-iqdi99pd 617 14 to to IN cord-015365-iqdi99pd 617 15 acute acute JJ cord-015365-iqdi99pd 617 16 rejection rejection NN cord-015365-iqdi99pd 617 17 , , , cord-015365-iqdi99pd 617 18 allograft allograft NN cord-015365-iqdi99pd 617 19 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 617 20 and and CC cord-015365-iqdi99pd 617 21 survival survival NN cord-015365-iqdi99pd 617 22 as as RB cord-015365-iqdi99pd 617 23 well well RB cord-015365-iqdi99pd 617 24 as as IN cord-015365-iqdi99pd 617 25 safety safety NN cord-015365-iqdi99pd 617 26 with with IN cord-015365-iqdi99pd 617 27 regard regard NN cord-015365-iqdi99pd 617 28 to to IN cord-015365-iqdi99pd 617 29 myelosuppression myelosuppression NN cord-015365-iqdi99pd 617 30 , , , cord-015365-iqdi99pd 617 31 infection infection NN cord-015365-iqdi99pd 617 32 , , , cord-015365-iqdi99pd 617 33 tumors tumor NNS cord-015365-iqdi99pd 617 34 , , , cord-015365-iqdi99pd 617 35 lipids lipid NNS cord-015365-iqdi99pd 617 36 and and CC cord-015365-iqdi99pd 617 37 body body NN cord-015365-iqdi99pd 617 38 growth growth NN cord-015365-iqdi99pd 617 39 was be VBD cord-015365-iqdi99pd 617 40 studied study VBN cord-015365-iqdi99pd 617 41 . . . cord-015365-iqdi99pd 618 1 Results result NNS cord-015365-iqdi99pd 618 2 . . . cord-015365-iqdi99pd 619 1 Mean mean JJ cord-015365-iqdi99pd 619 2 post post NNP cord-015365-iqdi99pd 620 1 Htx Htx NNP cord-015365-iqdi99pd 620 2 CsA csa NN cord-015365-iqdi99pd 620 3 exposure exposure NN cord-015365-iqdi99pd 620 4 was be VBD cord-015365-iqdi99pd 620 5 significantly significantly RB cord-015365-iqdi99pd 620 6 lower low JJR cord-015365-iqdi99pd 620 7 in in IN cord-015365-iqdi99pd 620 8 EVE EVE NNP cord-015365-iqdi99pd 620 9 treated treat VBD cord-015365-iqdi99pd 620 10 children child NNS cord-015365-iqdi99pd 620 11 compared compare VBN cord-015365-iqdi99pd 620 12 to to IN cord-015365-iqdi99pd 620 13 MMF MMF NNP cord-015365-iqdi99pd 620 14 at at IN cord-015365-iqdi99pd 620 15 month month NN cord-015365-iqdi99pd 620 16 6 6 CD cord-015365-iqdi99pd 621 1 ( ( -LRB- cord-015365-iqdi99pd 621 2 167 167 CD cord-015365-iqdi99pd 621 3 ng ng NN cord-015365-iqdi99pd 621 4 / / SYM cord-015365-iqdi99pd 621 5 ml ml NN cord-015365-iqdi99pd 622 1 versus versus IN cord-015365-iqdi99pd 622 2 284 284 CD cord-015365-iqdi99pd 622 3 ng ng NNP cord-015365-iqdi99pd 622 4 / / SYM cord-015365-iqdi99pd 622 5 ml ml NN cord-015365-iqdi99pd 622 6 ) ) -RRB- cord-015365-iqdi99pd 622 7 , , , cord-015365-iqdi99pd 622 8 month month NN cord-015365-iqdi99pd 622 9 12 12 CD cord-015365-iqdi99pd 623 1 ( ( -LRB- cord-015365-iqdi99pd 623 2 mean mean VB cord-015365-iqdi99pd 623 3 134 134 CD cord-015365-iqdi99pd 623 4 ng ng NN cord-015365-iqdi99pd 623 5 / / SYM cord-015365-iqdi99pd 623 6 ml ml NN cord-015365-iqdi99pd 623 7 versus versus IN cord-015365-iqdi99pd 623 8 235 235 CD cord-015365-iqdi99pd 623 9 ng ng NN cord-015365-iqdi99pd 623 10 / / SYM cord-015365-iqdi99pd 623 11 ml ml NN cord-015365-iqdi99pd 623 12 ) ) -RRB- cord-015365-iqdi99pd 623 13 and and CC cord-015365-iqdi99pd 623 14 month month NN cord-015365-iqdi99pd 623 15 24 24 CD cord-015365-iqdi99pd 623 16 ( ( -LRB- cord-015365-iqdi99pd 623 17 79 79 CD cord-015365-iqdi99pd 623 18 ng ng NN cord-015365-iqdi99pd 623 19 / / SYM cord-015365-iqdi99pd 623 20 ml ml NN cord-015365-iqdi99pd 624 1 versus versus IN cord-015365-iqdi99pd 624 2 76 76 CD cord-015365-iqdi99pd 624 3 ng ng NNP cord-015365-iqdi99pd 624 4 / / SYM cord-015365-iqdi99pd 624 5 ml ml NN cord-015365-iqdi99pd 624 6 ) ) -RRB- cord-015365-iqdi99pd 624 7 . . . cord-015365-iqdi99pd 625 1 Mean mean JJ cord-015365-iqdi99pd 625 2 daily daily JJ cord-015365-iqdi99pd 625 3 dose dose NN cord-015365-iqdi99pd 625 4 of of IN cord-015365-iqdi99pd 625 5 EVE EVE NNP cord-015365-iqdi99pd 625 6 was be VBD cord-015365-iqdi99pd 625 7 1.16 1.16 CD cord-015365-iqdi99pd 625 8 AE AE NNP cord-015365-iqdi99pd 625 9 0.56 0.56 CD cord-015365-iqdi99pd 625 10 mg mg NNP cord-015365-iqdi99pd 625 11 / / SYM cord-015365-iqdi99pd 625 12 m m NNP cord-015365-iqdi99pd 625 13 2 2 CD cord-015365-iqdi99pd 625 14 body body NN cord-015365-iqdi99pd 625 15 surface surface NN cord-015365-iqdi99pd 625 16 area area NN cord-015365-iqdi99pd 625 17 resulting result VBG cord-015365-iqdi99pd 625 18 in in IN cord-015365-iqdi99pd 625 19 trough trough NN cord-015365-iqdi99pd 625 20 levels level NNS cord-015365-iqdi99pd 625 21 of of IN cord-015365-iqdi99pd 625 22 4.8 4.8 CD cord-015365-iqdi99pd 625 23 AE AE NNP cord-015365-iqdi99pd 625 24 1.3 1.3 CD cord-015365-iqdi99pd 625 25 ng ng NN cord-015365-iqdi99pd 625 26 / / SYM cord-015365-iqdi99pd 625 27 ml ml NN cord-015365-iqdi99pd 625 28 by by IN cord-015365-iqdi99pd 625 29 24 24 CD cord-015365-iqdi99pd 625 30 months month NNS cord-015365-iqdi99pd 625 31 of of IN cord-015365-iqdi99pd 625 32 follow follow NN cord-015365-iqdi99pd 625 33 - - HYPH cord-015365-iqdi99pd 625 34 up up NN cord-015365-iqdi99pd 625 35 . . . cord-015365-iqdi99pd 626 1 Two two CD cord-015365-iqdi99pd 626 2 cases case NNS cord-015365-iqdi99pd 626 3 in in IN cord-015365-iqdi99pd 626 4 each each DT cord-015365-iqdi99pd 626 5 group group NN cord-015365-iqdi99pd 626 6 encountered encounter VBD cord-015365-iqdi99pd 626 7 biopsyproven biopsyproven NN cord-015365-iqdi99pd 626 8 acute acute JJ cord-015365-iqdi99pd 626 9 rejection rejection NN cord-015365-iqdi99pd 626 10 > > XX cord-015365-iqdi99pd 626 11 grade grade NN cord-015365-iqdi99pd 626 12 2R 2R NNP cord-015365-iqdi99pd 626 13 ( ( -LRB- cord-015365-iqdi99pd 626 14 7 7 CD cord-015365-iqdi99pd 626 15 % % NN cord-015365-iqdi99pd 626 16 versus versus IN cord-015365-iqdi99pd 626 17 8 8 CD cord-015365-iqdi99pd 626 18 % % NN cord-015365-iqdi99pd 626 19 ; ; : cord-015365-iqdi99pd 626 20 p p NN cord-015365-iqdi99pd 626 21 ¼ ¼ CD cord-015365-iqdi99pd 626 22 0.043 0.043 CD cord-015365-iqdi99pd 626 23 ) ) -RRB- cord-015365-iqdi99pd 626 24 . . . cord-015365-iqdi99pd 627 1 Cardiac cardiac JJ cord-015365-iqdi99pd 627 2 allograft allograft NN cord-015365-iqdi99pd 627 3 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 627 4 at at IN cord-015365-iqdi99pd 627 5 month month NN cord-015365-iqdi99pd 627 6 12 12 CD cord-015365-iqdi99pd 627 7 was be VBD cord-015365-iqdi99pd 627 8 detected detect VBN cord-015365-iqdi99pd 627 9 in in IN cord-015365-iqdi99pd 627 10 4 4 CD cord-015365-iqdi99pd 627 11 children child NNS cord-015365-iqdi99pd 627 12 ( ( -LRB- cord-015365-iqdi99pd 627 13 16 16 CD cord-015365-iqdi99pd 627 14 % % NN cord-015365-iqdi99pd 627 15 ) ) -RRB- cord-015365-iqdi99pd 627 16 with with IN cord-015365-iqdi99pd 627 17 EVE EVE NNP cord-015365-iqdi99pd 627 18 compared compare VBN cord-015365-iqdi99pd 627 19 to to IN cord-015365-iqdi99pd 627 20 18 18 CD cord-015365-iqdi99pd 627 21 % % NN cord-015365-iqdi99pd 627 22 in in IN cord-015365-iqdi99pd 627 23 MMF MMF NNP cord-015365-iqdi99pd 627 24 . . . cord-015365-iqdi99pd 628 1 Kidney kidney NN cord-015365-iqdi99pd 628 2 function function NN cord-015365-iqdi99pd 628 3 deteriorated deteriorate VBD cord-015365-iqdi99pd 628 4 in in IN cord-015365-iqdi99pd 628 5 both both DT cord-015365-iqdi99pd 628 6 groups group NNS cord-015365-iqdi99pd 628 7 during during IN cord-015365-iqdi99pd 628 8 the the DT cord-015365-iqdi99pd 628 9 first first JJ cord-015365-iqdi99pd 628 10 month month NN cord-015365-iqdi99pd 628 11 , , , cord-015365-iqdi99pd 628 12 recovering recover VBG cord-015365-iqdi99pd 628 13 after after IN cord-015365-iqdi99pd 628 14 24 24 CD cord-015365-iqdi99pd 628 15 months month NNS cord-015365-iqdi99pd 628 16 to to IN cord-015365-iqdi99pd 628 17 a a DT cord-015365-iqdi99pd 628 18 glomerular glomerular JJ cord-015365-iqdi99pd 628 19 filtration filtration NN cord-015365-iqdi99pd 628 20 rate rate NN cord-015365-iqdi99pd 628 21 of of IN cord-015365-iqdi99pd 628 22 95.1 95.1 CD cord-015365-iqdi99pd 628 23 AE AE NNP cord-015365-iqdi99pd 628 24 0.3 0.3 CD cord-015365-iqdi99pd 628 25 ml ml NN cord-015365-iqdi99pd 628 26 / / SYM cord-015365-iqdi99pd 628 27 min min NN cord-015365-iqdi99pd 628 28 / / SYM cord-015365-iqdi99pd 628 29 sqm sqm NN cord-015365-iqdi99pd 628 30 for for IN cord-015365-iqdi99pd 628 31 EVE EVE NNP cord-015365-iqdi99pd 628 32 versus versus IN cord-015365-iqdi99pd 628 33 88.9 88.9 CD cord-015365-iqdi99pd 628 34 AE AE NNP cord-015365-iqdi99pd 628 35 5.2 5.2 CD cord-015365-iqdi99pd 628 36 ml ml NNS cord-015365-iqdi99pd 628 37 / / SYM cord-015365-iqdi99pd 628 38 min min NN cord-015365-iqdi99pd 628 39 / / SYM cord-015365-iqdi99pd 628 40 sqm sqm NN cord-015365-iqdi99pd 628 41 for for IN cord-015365-iqdi99pd 628 42 MMF MMF NNP cord-015365-iqdi99pd 628 43 . . . cord-015365-iqdi99pd 629 1 Rates rate NNS cord-015365-iqdi99pd 629 2 of of IN cord-015365-iqdi99pd 629 3 myelosuppressive myelosuppressive NNP cord-015365-iqdi99pd 629 4 disorders disorder NNS cord-015365-iqdi99pd 629 5 ( ( -LRB- cord-015365-iqdi99pd 629 6 anaemia anaemia NN cord-015365-iqdi99pd 629 7 , , , cord-015365-iqdi99pd 629 8 leukopenia leukopenia NN cord-015365-iqdi99pd 629 9 , , , cord-015365-iqdi99pd 629 10 thrombocytopenia thrombocytopenia NN cord-015365-iqdi99pd 629 11 ) ) -RRB- cord-015365-iqdi99pd 629 12 , , , cord-015365-iqdi99pd 629 13 infections infection NNS cord-015365-iqdi99pd 629 14 and and CC cord-015365-iqdi99pd 629 15 hyperlipidaemia hyperlipidaemia NN cord-015365-iqdi99pd 629 16 was be VBD cord-015365-iqdi99pd 629 17 low low JJ cord-015365-iqdi99pd 629 18 and and CC cord-015365-iqdi99pd 629 19 comparable comparable JJ cord-015365-iqdi99pd 629 20 in in IN cord-015365-iqdi99pd 629 21 both both DT cord-015365-iqdi99pd 629 22 groups group NNS cord-015365-iqdi99pd 629 23 . . . cord-015365-iqdi99pd 630 1 Children child NNS cord-015365-iqdi99pd 630 2 with with IN cord-015365-iqdi99pd 630 3 EVE EVE NNP cord-015365-iqdi99pd 630 4 did do VBD cord-015365-iqdi99pd 630 5 not not RB cord-015365-iqdi99pd 630 6 encounter encounter VB cord-015365-iqdi99pd 630 7 inferiority inferiority NN cord-015365-iqdi99pd 630 8 in in IN cord-015365-iqdi99pd 630 9 body body NN cord-015365-iqdi99pd 630 10 growth growth NN cord-015365-iqdi99pd 630 11 . . . cord-015365-iqdi99pd 631 1 1 1 CD cord-015365-iqdi99pd 631 2 child child NN cord-015365-iqdi99pd 631 3 with with IN cord-015365-iqdi99pd 631 4 EVE EVE NNP cord-015365-iqdi99pd 631 5 died die VBD cord-015365-iqdi99pd 631 6 following follow VBG cord-015365-iqdi99pd 631 7 intractable intractable JJ cord-015365-iqdi99pd 631 8 ventricular ventricular JJ cord-015365-iqdi99pd 631 9 fibrillation fibrillation NN cord-015365-iqdi99pd 631 10 during during IN cord-015365-iqdi99pd 631 11 myocardial myocardial JJ cord-015365-iqdi99pd 631 12 biopsy biopsy NN cord-015365-iqdi99pd 631 13 compared compare VBN cord-015365-iqdi99pd 631 14 to to IN cord-015365-iqdi99pd 631 15 5 5 CD cord-015365-iqdi99pd 631 16 children child NNS cord-015365-iqdi99pd 631 17 with with IN cord-015365-iqdi99pd 631 18 MMF mmf NN cord-015365-iqdi99pd 631 19 ( ( -LRB- cord-015365-iqdi99pd 631 20 2 2 CD cord-015365-iqdi99pd 631 21 deaths death NNS cord-015365-iqdi99pd 631 22 due due JJ cord-015365-iqdi99pd 631 23 to to IN cord-015365-iqdi99pd 631 24 allograft allograft NN cord-015365-iqdi99pd 631 25 rejection rejection NN cord-015365-iqdi99pd 631 26 ) ) -RRB- cord-015365-iqdi99pd 631 27 . . . cord-015365-iqdi99pd 632 1 Conclusions conclusion NNS cord-015365-iqdi99pd 632 2 . . . cord-015365-iqdi99pd 633 1 Everolimus Everolimus NNP cord-015365-iqdi99pd 633 2 with with IN cord-015365-iqdi99pd 633 3 reduced reduce VBN cord-015365-iqdi99pd 633 4 CsA csa NN cord-015365-iqdi99pd 633 5 combined combine VBN cord-015365-iqdi99pd 633 6 with with IN cord-015365-iqdi99pd 633 7 steroids steroid NNS cord-015365-iqdi99pd 633 8 in in IN cord-015365-iqdi99pd 633 9 paedriatic paedriatic JJ cord-015365-iqdi99pd 633 10 cardiac cardiac JJ cord-015365-iqdi99pd 633 11 transplant transplant NN cord-015365-iqdi99pd 633 12 recipients recipient NNS cord-015365-iqdi99pd 633 13 enables enable VBZ cord-015365-iqdi99pd 633 14 high high JJ cord-015365-iqdi99pd 633 15 efficacy efficacy NN cord-015365-iqdi99pd 633 16 and and CC cord-015365-iqdi99pd 633 17 is be VBZ cord-015365-iqdi99pd 633 18 comparatively comparatively RB cord-015365-iqdi99pd 633 19 safe safe JJ cord-015365-iqdi99pd 633 20 to to IN cord-015365-iqdi99pd 633 21 immunosuppression immunosuppression NN cord-015365-iqdi99pd 633 22 with with IN cord-015365-iqdi99pd 633 23 MMF mmf NN cord-015365-iqdi99pd 633 24 and and CC cord-015365-iqdi99pd 633 25 standard standard JJ cord-015365-iqdi99pd 633 26 exposure exposure NN cord-015365-iqdi99pd 633 27 of of IN cord-015365-iqdi99pd 633 28 CsA. CsA. NNP cord-015365-iqdi99pd 633 29 Transplantation transplantation NN cord-015365-iqdi99pd 633 30 of of IN cord-015365-iqdi99pd 633 31 a a DT cord-015365-iqdi99pd 633 32 minor minor RB cord-015365-iqdi99pd 633 33 - - HYPH cord-015365-iqdi99pd 633 34 mismatched mismatched JJ cord-015365-iqdi99pd 633 35 skin skin NN cord-015365-iqdi99pd 633 36 graft graft NN cord-015365-iqdi99pd 633 37 elicits elicit VBZ cord-015365-iqdi99pd 633 38 a a DT cord-015365-iqdi99pd 633 39 rapid rapid JJ cord-015365-iqdi99pd 633 40 humoral humoral JJ cord-015365-iqdi99pd 633 41 response response NN cord-015365-iqdi99pd 633 42 including include VBG cord-015365-iqdi99pd 633 43 the the DT cord-015365-iqdi99pd 633 44 induction induction NN cord-015365-iqdi99pd 633 45 of of IN cord-015365-iqdi99pd 633 46 antigen antigen NN cord-015365-iqdi99pd 633 47 - - HYPH cord-015365-iqdi99pd 633 48 specific specific JJ cord-015365-iqdi99pd 633 49 IgE IgE NNP cord-015365-iqdi99pd 633 50 Background Background NNP cord-015365-iqdi99pd 633 51 . . . cord-015365-iqdi99pd 634 1 Sensitization sensitization NN cord-015365-iqdi99pd 634 2 to to IN cord-015365-iqdi99pd 634 3 major major JJ cord-015365-iqdi99pd 634 4 and and CC cord-015365-iqdi99pd 634 5 minor minor JJ cord-015365-iqdi99pd 634 6 antigens antigen NNS cord-015365-iqdi99pd 634 7 is be VBZ cord-015365-iqdi99pd 634 8 a a DT cord-015365-iqdi99pd 634 9 critical critical JJ cord-015365-iqdi99pd 634 10 problem problem NN cord-015365-iqdi99pd 634 11 in in IN cord-015365-iqdi99pd 634 12 transplantation transplantation NN cord-015365-iqdi99pd 634 13 medicine medicine NN cord-015365-iqdi99pd 634 14 with with IN cord-015365-iqdi99pd 634 15 antibodies antibody NNS cord-015365-iqdi99pd 634 16 of of IN cord-015365-iqdi99pd 634 17 IgM IgM NNP cord-015365-iqdi99pd 634 18 , , , cord-015365-iqdi99pd 634 19 IgA IgA NNP cord-015365-iqdi99pd 634 20 and and CC cord-015365-iqdi99pd 634 21 IgG IgG NNP cord-015365-iqdi99pd 634 22 isotypes isotypes NNP cord-015365-iqdi99pd 634 23 have have VBP cord-015365-iqdi99pd 634 24 been be VBN cord-015365-iqdi99pd 634 25 demonstrated demonstrate VBN cord-015365-iqdi99pd 634 26 towards towards IN cord-015365-iqdi99pd 634 27 major major JJ cord-015365-iqdi99pd 634 28 ( ( -LRB- cord-015365-iqdi99pd 634 29 i.e. i.e. FW cord-015365-iqdi99pd 634 30 MHC MHC NNP cord-015365-iqdi99pd 634 31 ) ) -RRB- cord-015365-iqdi99pd 634 32 and and CC cord-015365-iqdi99pd 634 33 minor minor JJ cord-015365-iqdi99pd 634 34 ( ( -LRB- cord-015365-iqdi99pd 634 35 i.e. i.e. FW cord-015365-iqdi99pd 634 36 non non FW cord-015365-iqdi99pd 634 37 - - JJ cord-015365-iqdi99pd 634 38 MHC MHC NNP cord-015365-iqdi99pd 634 39 ) ) -RRB- cord-015365-iqdi99pd 634 40 antigens antigen NNS cord-015365-iqdi99pd 634 41 . . . cord-015365-iqdi99pd 635 1 In in IN cord-015365-iqdi99pd 635 2 a a DT cord-015365-iqdi99pd 635 3 new new JJ cord-015365-iqdi99pd 635 4 transgenic transgenic JJ cord-015365-iqdi99pd 635 5 mouse mouse NN cord-015365-iqdi99pd 635 6 model model NN cord-015365-iqdi99pd 635 7 we -PRON- PRP cord-015365-iqdi99pd 635 8 investigated investigate VBD cord-015365-iqdi99pd 635 9 humoral humoral JJ cord-015365-iqdi99pd 635 10 antigenspecific antigenspecific JJ cord-015365-iqdi99pd 635 11 responses response NNS cord-015365-iqdi99pd 635 12 towards towards IN cord-015365-iqdi99pd 635 13 a a DT cord-015365-iqdi99pd 635 14 highly highly RB cord-015365-iqdi99pd 635 15 immunogenic immunogenic JJ cord-015365-iqdi99pd 635 16 non non JJ cord-015365-iqdi99pd 635 17 - - JJ cord-015365-iqdi99pd 635 18 MHC mhc JJ cord-015365-iqdi99pd 635 19 antigen antigen NN cord-015365-iqdi99pd 635 20 . . . cord-015365-iqdi99pd 636 1 A a DT cord-015365-iqdi99pd 636 2 transgenic transgenic JJ cord-015365-iqdi99pd 636 3 mouse mouse NN cord-015365-iqdi99pd 636 4 expressing express VBG cord-015365-iqdi99pd 636 5 the the DT cord-015365-iqdi99pd 636 6 well well RB cord-015365-iqdi99pd 636 7 - - HYPH cord-015365-iqdi99pd 636 8 characterized characterize VBN cord-015365-iqdi99pd 636 9 major major JJ cord-015365-iqdi99pd 636 10 grass grass NN cord-015365-iqdi99pd 636 11 pollen pollen NN cord-015365-iqdi99pd 636 12 allergen allergen NN cord-015365-iqdi99pd 636 13 Phl Phl NNP cord-015365-iqdi99pd 636 14 p p NNP cord-015365-iqdi99pd 636 15 5 5 CD cord-015365-iqdi99pd 636 16 ubiquitously ubiquitously RB cord-015365-iqdi99pd 636 17 on on IN cord-015365-iqdi99pd 636 18 the the DT cord-015365-iqdi99pd 636 19 cell cell NN cord-015365-iqdi99pd 636 20 surface surface NN cord-015365-iqdi99pd 636 21 was be VBD cord-015365-iqdi99pd 636 22 generated generate VBN cord-015365-iqdi99pd 636 23 . . . cord-015365-iqdi99pd 637 1 Methods method NNS cord-015365-iqdi99pd 637 2 . . . cord-015365-iqdi99pd 638 1 A a DT cord-015365-iqdi99pd 638 2 Phl Phl NNP cord-015365-iqdi99pd 638 3 p p NN cord-015365-iqdi99pd 638 4 5-transgenic 5-transgenic CD cord-015365-iqdi99pd 638 5 Balb Balb NNP cord-015365-iqdi99pd 638 6 / / SYM cord-015365-iqdi99pd 638 7 c c NN cord-015365-iqdi99pd 638 8 mouse mouse NN cord-015365-iqdi99pd 638 9 was be VBD cord-015365-iqdi99pd 638 10 generated generate VBN cord-015365-iqdi99pd 638 11 by by IN cord-015365-iqdi99pd 638 12 pronuclear pronuclear NN cord-015365-iqdi99pd 638 13 injection injection NN cord-015365-iqdi99pd 638 14 integrating integrate VBG cord-015365-iqdi99pd 638 15 Phl Phl NNP cord-015365-iqdi99pd 638 16 p p NNP cord-015365-iqdi99pd 638 17 5 5 CD cord-015365-iqdi99pd 638 18 ( ( -LRB- cord-015365-iqdi99pd 638 19 and and CC cord-015365-iqdi99pd 638 20 GFP GFP NNP cord-015365-iqdi99pd 638 21 ) ) -RRB- cord-015365-iqdi99pd 638 22 fused fuse VBD cord-015365-iqdi99pd 638 23 to to IN cord-015365-iqdi99pd 638 24 a a DT cord-015365-iqdi99pd 638 25 leader leader NN cord-015365-iqdi99pd 638 26 peptide peptide NN cord-015365-iqdi99pd 638 27 and and CC cord-015365-iqdi99pd 638 28 a a DT cord-015365-iqdi99pd 638 29 transmembrane transmembrane NN cord-015365-iqdi99pd 638 30 domain domain NN cord-015365-iqdi99pd 638 31 . . . cord-015365-iqdi99pd 639 1 Splenocytes Splenocytes NNP cord-015365-iqdi99pd 639 2 ( ( -LRB- cord-015365-iqdi99pd 639 3 2.5Â106 2.5â106 CD cord-015365-iqdi99pd 639 4 per per IN cord-015365-iqdi99pd 639 5 mouse mouse NN cord-015365-iqdi99pd 639 6 ) ) -RRB- cord-015365-iqdi99pd 639 7 , , , cord-015365-iqdi99pd 639 8 cell cell NN cord-015365-iqdi99pd 639 9 extracts extract NNS cord-015365-iqdi99pd 639 10 containing contain VBG cord-015365-iqdi99pd 639 11 mainly mainly RB cord-015365-iqdi99pd 639 12 membrane membrane NN cord-015365-iqdi99pd 639 13 proteins protein NNS cord-015365-iqdi99pd 639 14 and and CC cord-015365-iqdi99pd 639 15 recombinant recombinant JJ cord-015365-iqdi99pd 640 1 ( ( -LRB- cord-015365-iqdi99pd 640 2 r r NN cord-015365-iqdi99pd 640 3 ) ) -RRB- cord-015365-iqdi99pd 640 4 Phl phl NN cord-015365-iqdi99pd 640 5 p p NN cord-015365-iqdi99pd 640 6 5 5 CD cord-015365-iqdi99pd 640 7 [ [ -LRB- cord-015365-iqdi99pd 640 8 5 5 CD cord-015365-iqdi99pd 640 9 mg mg NN cord-015365-iqdi99pd 640 10 AE AE NNP cord-015365-iqdi99pd 640 11 Al(OH)3 Al(OH)3 : cord-015365-iqdi99pd 640 12 per per IN cord-015365-iqdi99pd 640 13 mouse mouse NN cord-015365-iqdi99pd 640 14 ] ] -RRB- cord-015365-iqdi99pd 640 15 were be VBD cord-015365-iqdi99pd 640 16 injected inject VBN cord-015365-iqdi99pd 640 17 subcutaneously subcutaneously RB cord-015365-iqdi99pd 640 18 into into IN cord-015365-iqdi99pd 640 19 naïve naïve JJ cord-015365-iqdi99pd 640 20 Balb Balb NNP cord-015365-iqdi99pd 640 21 / / SYM cord-015365-iqdi99pd 640 22 c c NN cord-015365-iqdi99pd 640 23 mice mouse NNS cord-015365-iqdi99pd 640 24 ( ( -LRB- cord-015365-iqdi99pd 640 25 n n CC cord-015365-iqdi99pd 640 26 ¼ ¼ NNP cord-015365-iqdi99pd 640 27 8 8 CD cord-015365-iqdi99pd 640 28 per per IN cord-015365-iqdi99pd 640 29 group group NN cord-015365-iqdi99pd 640 30 ) ) -RRB- cord-015365-iqdi99pd 640 31 . . . cord-015365-iqdi99pd 641 1 Furthermore furthermore RB cord-015365-iqdi99pd 641 2 tail tail VB cord-015365-iqdi99pd 641 3 skin skin NN cord-015365-iqdi99pd 641 4 of of IN cord-015365-iqdi99pd 641 5 Phl Phl NNP cord-015365-iqdi99pd 641 6 p p NN cord-015365-iqdi99pd 641 7 5-transgenic 5-transgenic CD cord-015365-iqdi99pd 641 8 mice mouse NNS cord-015365-iqdi99pd 641 9 was be VBD cord-015365-iqdi99pd 641 10 grafted graft VBN cord-015365-iqdi99pd 641 11 onto onto IN cord-015365-iqdi99pd 641 12 naïve naïve JJ cord-015365-iqdi99pd 641 13 Balb Balb NNP cord-015365-iqdi99pd 641 14 / / SYM cord-015365-iqdi99pd 641 15 c c NNP cord-015365-iqdi99pd 641 16 ( ( -LRB- cord-015365-iqdi99pd 641 17 n n NNP cord-015365-iqdi99pd 641 18 ¼ ¼ NNP cord-015365-iqdi99pd 641 19 13 13 CD cord-015365-iqdi99pd 641 20 in in IN cord-015365-iqdi99pd 641 21 two two CD cord-015365-iqdi99pd 641 22 independent independent JJ cord-015365-iqdi99pd 641 23 experiments experiment NNS cord-015365-iqdi99pd 641 24 ) ) -RRB- cord-015365-iqdi99pd 641 25 . . . cord-015365-iqdi99pd 642 1 The the DT cord-015365-iqdi99pd 642 2 Phl Phl NNP cord-015365-iqdi99pd 642 3 p p NN cord-015365-iqdi99pd 642 4 5-specific 5-specific CD cord-015365-iqdi99pd 642 5 humoral humoral JJ cord-015365-iqdi99pd 642 6 response response NN cord-015365-iqdi99pd 642 7 was be VBD cord-015365-iqdi99pd 642 8 determined determine VBN cord-015365-iqdi99pd 642 9 in in IN cord-015365-iqdi99pd 642 10 sera sera NNP cord-015365-iqdi99pd 642 11 by by IN cord-015365-iqdi99pd 642 12 ELISAs elisa NNS cord-015365-iqdi99pd 642 13 and and CC cord-015365-iqdi99pd 642 14 T t NN cord-015365-iqdi99pd 642 15 - - HYPH cord-015365-iqdi99pd 642 16 cell cell NN cord-015365-iqdi99pd 642 17 proliferation proliferation NN cord-015365-iqdi99pd 642 18 assays assay NNS cord-015365-iqdi99pd 642 19 were be VBD cord-015365-iqdi99pd 642 20 assessed assess VBN cord-015365-iqdi99pd 642 21 . . . cord-015365-iqdi99pd 643 1 Results result NNS cord-015365-iqdi99pd 643 2 . . . cord-015365-iqdi99pd 644 1 Surprisingly surprisingly RB cord-015365-iqdi99pd 644 2 , , , cord-015365-iqdi99pd 644 3 a a DT cord-015365-iqdi99pd 644 4 prompt prompt JJ cord-015365-iqdi99pd 644 5 rejection rejection NN cord-015365-iqdi99pd 644 6 of of IN cord-015365-iqdi99pd 644 7 Phl Phl NNP cord-015365-iqdi99pd 644 8 p p NN cord-015365-iqdi99pd 644 9 5-transgenic 5-transgenic CD cord-015365-iqdi99pd 644 10 skin skin NN cord-015365-iqdi99pd 644 11 was be VBD cord-015365-iqdi99pd 644 12 elicited elicit VBN cord-015365-iqdi99pd 644 13 ( ( -LRB- cord-015365-iqdi99pd 644 14 within within IN cord-015365-iqdi99pd 644 15 8 8 CD cord-015365-iqdi99pd 644 16 - - SYM cord-015365-iqdi99pd 644 17 10 10 CD cord-015365-iqdi99pd 644 18 days day NNS cord-015365-iqdi99pd 644 19 ) ) -RRB- cord-015365-iqdi99pd 644 20 , , , cord-015365-iqdi99pd 644 21 accompanied accompany VBN cord-015365-iqdi99pd 644 22 by by IN cord-015365-iqdi99pd 644 23 a a DT cord-015365-iqdi99pd 644 24 strong strong JJ cord-015365-iqdi99pd 644 25 Phl Phl NNP cord-015365-iqdi99pd 644 26 p p NN cord-015365-iqdi99pd 644 27 5 5 CD cord-015365-iqdi99pd 644 28 specific specific JJ cord-015365-iqdi99pd 644 29 antibody antibody NN cord-015365-iqdi99pd 644 30 response response NN cord-015365-iqdi99pd 644 31 including include VBG cord-015365-iqdi99pd 645 1 Phl Phl NNP cord-015365-iqdi99pd 645 2 p p NN cord-015365-iqdi99pd 645 3 5-specific 5-specific CD cord-015365-iqdi99pd 645 4 IgE. ige. NN cord-015365-iqdi99pd 646 1 Additionally additionally RB cord-015365-iqdi99pd 646 2 to to IN cord-015365-iqdi99pd 646 3 the the DT cord-015365-iqdi99pd 646 4 skin skin NN cord-015365-iqdi99pd 646 5 grafted graft VBN cord-015365-iqdi99pd 646 6 group group NN cord-015365-iqdi99pd 646 7 , , , cord-015365-iqdi99pd 646 8 mice mouse NNS cord-015365-iqdi99pd 646 9 receiving receive VBG cord-015365-iqdi99pd 646 10 splenocytes splenocyte NNS cord-015365-iqdi99pd 646 11 or or CC cord-015365-iqdi99pd 646 12 rPhl rPhl NNP cord-015365-iqdi99pd 646 13 p p NN cord-015365-iqdi99pd 646 14 5 5 CD cord-015365-iqdi99pd 646 15 plus plus NN cord-015365-iqdi99pd 646 16 adjuvant adjuvant NN cord-015365-iqdi99pd 646 17 showed show VBD cord-015365-iqdi99pd 646 18 a a DT cord-015365-iqdi99pd 646 19 comparable comparable JJ cord-015365-iqdi99pd 646 20 response response NN cord-015365-iqdi99pd 646 21 in in IN cord-015365-iqdi99pd 646 22 terms term NNS cord-015365-iqdi99pd 646 23 of of IN cord-015365-iqdi99pd 646 24 Phl Phl NNP cord-015365-iqdi99pd 646 25 p p NNP cord-015365-iqdi99pd 646 26 5-specific 5-specific CD cord-015365-iqdi99pd 646 27 IgE IgE NNP cord-015365-iqdi99pd 646 28 throughout throughout IN cord-015365-iqdi99pd 646 29 the the DT cord-015365-iqdi99pd 646 30 whole whole JJ cord-015365-iqdi99pd 646 31 follow follow NN cord-015365-iqdi99pd 646 32 - - HYPH cord-015365-iqdi99pd 646 33 up up NN cord-015365-iqdi99pd 646 34 ( ( -LRB- cord-015365-iqdi99pd 646 35 week week NN cord-015365-iqdi99pd 646 36 1 1 CD cord-015365-iqdi99pd 646 37 , , , cord-015365-iqdi99pd 646 38 2 2 CD cord-015365-iqdi99pd 646 39 , , , cord-015365-iqdi99pd 646 40 3 3 CD cord-015365-iqdi99pd 646 41 , , , cord-015365-iqdi99pd 646 42 5 5 CD cord-015365-iqdi99pd 646 43 , , , cord-015365-iqdi99pd 646 44 7 7 CD cord-015365-iqdi99pd 646 45 , , , cord-015365-iqdi99pd 646 46 9 9 CD cord-015365-iqdi99pd 646 47 , , , cord-015365-iqdi99pd 646 48 11 11 CD cord-015365-iqdi99pd 646 49 ) ) -RRB- cord-015365-iqdi99pd 646 50 suggesting suggest VBG cord-015365-iqdi99pd 646 51 an an DT cord-015365-iqdi99pd 646 52 unusually unusually RB cord-015365-iqdi99pd 646 53 strong strong JJ cord-015365-iqdi99pd 646 54 immune immune JJ cord-015365-iqdi99pd 646 55 response response NN cord-015365-iqdi99pd 646 56 to to IN cord-015365-iqdi99pd 646 57 cell cell NN cord-015365-iqdi99pd 646 58 or or CC cord-015365-iqdi99pd 646 59 tissue tissue NN cord-015365-iqdi99pd 646 60 - - HYPH cord-015365-iqdi99pd 646 61 bound bind VBN cord-015365-iqdi99pd 646 62 Phl Phl NNP cord-015365-iqdi99pd 646 63 p p NN cord-015365-iqdi99pd 646 64 5 5 CD cord-015365-iqdi99pd 646 65 . . . cord-015365-iqdi99pd 647 1 Furthermore furthermore RB cord-015365-iqdi99pd 647 2 Phl Phl NNP cord-015365-iqdi99pd 647 3 p p NNP cord-015365-iqdi99pd 647 4 5-specific 5-specific CD cord-015365-iqdi99pd 647 5 IgG IgG NNP cord-015365-iqdi99pd 647 6 isotypes isotypes NNP cord-015365-iqdi99pd 647 7 , , , cord-015365-iqdi99pd 647 8 IgA IgA NNP cord-015365-iqdi99pd 647 9 and and CC cord-015365-iqdi99pd 647 10 IgM IgM NNP cord-015365-iqdi99pd 647 11 were be VBD cord-015365-iqdi99pd 647 12 induced induce VBN cord-015365-iqdi99pd 647 13 . . . cord-015365-iqdi99pd 648 1 Besides besides IN cord-015365-iqdi99pd 648 2 splenocyte splenocyte NN cord-015365-iqdi99pd 648 3 - - HYPH cord-015365-iqdi99pd 648 4 proliferation proliferation NN cord-015365-iqdi99pd 648 5 assays assay NNS cord-015365-iqdi99pd 648 6 showed show VBD cord-015365-iqdi99pd 648 7 Phl Phl NNP cord-015365-iqdi99pd 648 8 p p NN cord-015365-iqdi99pd 648 9 5 5 CD cord-015365-iqdi99pd 648 10 specific specific JJ cord-015365-iqdi99pd 648 11 T t NN cord-015365-iqdi99pd 648 12 - - HYPH cord-015365-iqdi99pd 648 13 cell cell NN cord-015365-iqdi99pd 648 14 responses response NNS cord-015365-iqdi99pd 648 15 in in IN cord-015365-iqdi99pd 648 16 all all DT cord-015365-iqdi99pd 648 17 groups group NNS cord-015365-iqdi99pd 648 18 of of IN cord-015365-iqdi99pd 648 19 mice mouse NNS cord-015365-iqdi99pd 648 20 that that WDT cord-015365-iqdi99pd 648 21 showed show VBD cord-015365-iqdi99pd 648 22 strong strong JJ cord-015365-iqdi99pd 648 23 humoral humoral JJ cord-015365-iqdi99pd 648 24 responses response NNS cord-015365-iqdi99pd 648 25 . . . cord-015365-iqdi99pd 649 1 Conclusions conclusion NNS cord-015365-iqdi99pd 649 2 . . . cord-015365-iqdi99pd 650 1 The the DT cord-015365-iqdi99pd 650 2 high high JJ cord-015365-iqdi99pd 650 3 immunogenicity immunogenicity NN cord-015365-iqdi99pd 650 4 of of IN cord-015365-iqdi99pd 650 5 tissue tissue NN cord-015365-iqdi99pd 650 6 - - HYPH cord-015365-iqdi99pd 650 7 bound bind VBN cord-015365-iqdi99pd 650 8 Phl Phl NNP cord-015365-iqdi99pd 650 9 p p NN cord-015365-iqdi99pd 650 10 5 5 CD cord-015365-iqdi99pd 650 11 may may MD cord-015365-iqdi99pd 650 12 represent represent VB cord-015365-iqdi99pd 650 13 a a DT cord-015365-iqdi99pd 650 14 new new JJ cord-015365-iqdi99pd 650 15 stringent stringent JJ cord-015365-iqdi99pd 650 16 model model NN cord-015365-iqdi99pd 650 17 for for IN cord-015365-iqdi99pd 650 18 studying study VBG cord-015365-iqdi99pd 650 19 humoral humoral JJ cord-015365-iqdi99pd 650 20 responses response NNS cord-015365-iqdi99pd 650 21 towards towards IN cord-015365-iqdi99pd 650 22 non non JJ cord-015365-iqdi99pd 650 23 - - JJ cord-015365-iqdi99pd 650 24 MHC MHC NNP cord-015365-iqdi99pd 650 25 antigens antigen NNS cord-015365-iqdi99pd 650 26 . . . cord-015365-iqdi99pd 651 1 Notably notably RB cord-015365-iqdi99pd 651 2 , , , cord-015365-iqdi99pd 651 3 the the DT cord-015365-iqdi99pd 651 4 immune immune JJ cord-015365-iqdi99pd 651 5 reaction reaction NN cord-015365-iqdi99pd 651 6 included include VBD cord-015365-iqdi99pd 651 7 a a DT cord-015365-iqdi99pd 651 8 rapid rapid JJ cord-015365-iqdi99pd 651 9 IgE IgE NNP cord-015365-iqdi99pd 651 10 response response NN cord-015365-iqdi99pd 651 11 in in IN cord-015365-iqdi99pd 651 12 this this DT cord-015365-iqdi99pd 651 13 model model NN cord-015365-iqdi99pd 651 14 . . . cord-015365-iqdi99pd 652 1 The the DT cord-015365-iqdi99pd 652 2 influence influence NN cord-015365-iqdi99pd 652 3 of of IN cord-015365-iqdi99pd 652 4 recipient recipient NN cord-015365-iqdi99pd 652 5 age age NN cord-015365-iqdi99pd 652 6 on on IN cord-015365-iqdi99pd 652 7 chimerism chimerism NN cord-015365-iqdi99pd 652 8 - - HYPH cord-015365-iqdi99pd 652 9 based base VBN cord-015365-iqdi99pd 652 10 tolerance tolerance NN cord-015365-iqdi99pd 652 11 induction induction NN cord-015365-iqdi99pd 652 12 K. K. NNP cord-015365-iqdi99pd 652 13 Hock Hock NNP cord-015365-iqdi99pd 652 14 1,2 1,2 CD cord-015365-iqdi99pd 652 15 , , , cord-015365-iqdi99pd 652 16 R. R. NNP cord-015365-iqdi99pd 652 17 Oberhuber Oberhuber NNP cord-015365-iqdi99pd 652 18 2,3 2,3 CD cord-015365-iqdi99pd 652 19 , , , cord-015365-iqdi99pd 652 20 Y.-L. Y.-L. NNP cord-015365-iqdi99pd 652 21 Lee Lee NNP cord-015365-iqdi99pd 652 22 2 2 CD cord-015365-iqdi99pd 652 23 , , , cord-015365-iqdi99pd 652 24 T. T. NNP cord-015365-iqdi99pd 652 25 Wekerle Wekerle NNP cord-015365-iqdi99pd 652 26 1 1 CD cord-015365-iqdi99pd 652 27 , , , cord-015365-iqdi99pd 652 28 S. S. NNP cord-015365-iqdi99pd 652 29 G. G. NNP cord-015365-iqdi99pd 652 30 Tullius Tullius NNP cord-015365-iqdi99pd 652 31 2 2 CD cord-015365-iqdi99pd 652 32 Background Background NNP cord-015365-iqdi99pd 652 33 . . . cord-015365-iqdi99pd 653 1 Immune immune JJ cord-015365-iqdi99pd 653 2 senescence senescence NN cord-015365-iqdi99pd 653 3 substantially substantially RB cord-015365-iqdi99pd 653 4 alters alter VBZ cord-015365-iqdi99pd 653 5 alloreactivity alloreactivity NN cord-015365-iqdi99pd 653 6 . . . cord-015365-iqdi99pd 654 1 Higher high JJR cord-015365-iqdi99pd 654 2 frequencies frequency NNS cord-015365-iqdi99pd 654 3 of of IN cord-015365-iqdi99pd 654 4 memory memory NN cord-015365-iqdi99pd 654 5 T t NN cord-015365-iqdi99pd 654 6 cells cell NNS cord-015365-iqdi99pd 654 7 ( ( -LRB- cord-015365-iqdi99pd 654 8 Tmem Tmem NNP cord-015365-iqdi99pd 654 9 ) ) -RRB- cord-015365-iqdi99pd 654 10 found find VBD cord-015365-iqdi99pd 654 11 in in IN cord-015365-iqdi99pd 654 12 older old JJR cord-015365-iqdi99pd 654 13 recipients recipient NNS cord-015365-iqdi99pd 654 14 are be VBP cord-015365-iqdi99pd 654 15 considered consider VBN cord-015365-iqdi99pd 654 16 a a DT cord-015365-iqdi99pd 654 17 substantial substantial JJ cord-015365-iqdi99pd 654 18 barrier barrier NN cord-015365-iqdi99pd 654 19 to to IN cord-015365-iqdi99pd 654 20 tolerance tolerance NN cord-015365-iqdi99pd 654 21 induction induction NN cord-015365-iqdi99pd 654 22 . . . cord-015365-iqdi99pd 655 1 Tolerance tolerance NN cord-015365-iqdi99pd 655 2 induction induction NN cord-015365-iqdi99pd 655 3 through through IN cord-015365-iqdi99pd 655 4 mixed mixed JJ cord-015365-iqdi99pd 655 5 chimerism chimerism NN cord-015365-iqdi99pd 655 6 holds hold VBZ cord-015365-iqdi99pd 655 7 promise promise NN cord-015365-iqdi99pd 655 8 for for IN cord-015365-iqdi99pd 655 9 clinical clinical JJ cord-015365-iqdi99pd 655 10 translation translation NN cord-015365-iqdi99pd 655 11 but but CC cord-015365-iqdi99pd 655 12 has have VBZ cord-015365-iqdi99pd 655 13 only only RB cord-015365-iqdi99pd 655 14 been be VBN cord-015365-iqdi99pd 655 15 investigated investigate VBN cord-015365-iqdi99pd 655 16 in in IN cord-015365-iqdi99pd 655 17 young young JJ cord-015365-iqdi99pd 655 18 recipients recipient NNS cord-015365-iqdi99pd 655 19 so so RB cord-015365-iqdi99pd 655 20 far far RB cord-015365-iqdi99pd 655 21 . . . cord-015365-iqdi99pd 656 1 As as IN cord-015365-iqdi99pd 656 2 the the DT cord-015365-iqdi99pd 656 3 average average JJ cord-015365-iqdi99pd 656 4 recipient recipient NN cord-015365-iqdi99pd 656 5 age age NN cord-015365-iqdi99pd 656 6 has have VBZ cord-015365-iqdi99pd 656 7 increased increase VBN cord-015365-iqdi99pd 656 8 substantially substantially RB cord-015365-iqdi99pd 656 9 in in IN cord-015365-iqdi99pd 656 10 clinical clinical JJ cord-015365-iqdi99pd 656 11 organ organ NN cord-015365-iqdi99pd 656 12 transplantation transplantation NN cord-015365-iqdi99pd 656 13 , , , cord-015365-iqdi99pd 656 14 we -PRON- PRP cord-015365-iqdi99pd 656 15 investigated investigate VBD cord-015365-iqdi99pd 656 16 the the DT cord-015365-iqdi99pd 656 17 consequences consequence NNS cord-015365-iqdi99pd 656 18 of of IN cord-015365-iqdi99pd 656 19 recipient recipient NN cord-015365-iqdi99pd 656 20 age age NN cord-015365-iqdi99pd 656 21 on on IN cord-015365-iqdi99pd 656 22 the the DT cord-015365-iqdi99pd 656 23 outcome outcome NN cord-015365-iqdi99pd 656 24 of of IN cord-015365-iqdi99pd 656 25 costimulation costimulation NN cord-015365-iqdi99pd 656 26 blockade blockade NN cord-015365-iqdi99pd 656 27 based base VBN cord-015365-iqdi99pd 656 28 allogeneic allogeneic IN cord-015365-iqdi99pd 656 29 bone bone NN cord-015365-iqdi99pd 656 30 marrow marrow NN cord-015365-iqdi99pd 656 31 transplantation transplantation NN cord-015365-iqdi99pd 656 32 ( ( -LRB- cord-015365-iqdi99pd 656 33 BMT BMT NNP cord-015365-iqdi99pd 656 34 ) ) -RRB- cord-015365-iqdi99pd 656 35 for for IN cord-015365-iqdi99pd 656 36 the the DT cord-015365-iqdi99pd 656 37 purpose purpose NN cord-015365-iqdi99pd 656 38 of of IN cord-015365-iqdi99pd 656 39 mixed mixed JJ cord-015365-iqdi99pd 656 40 chimerism chimerism NN cord-015365-iqdi99pd 656 41 and and CC cord-015365-iqdi99pd 656 42 tolerance tolerance NN cord-015365-iqdi99pd 656 43 induction induction NN cord-015365-iqdi99pd 656 44 . . . cord-015365-iqdi99pd 657 1 Methods method NNS cord-015365-iqdi99pd 657 2 . . . cord-015365-iqdi99pd 658 1 Young young JJ cord-015365-iqdi99pd 658 2 ( ( -LRB- cord-015365-iqdi99pd 658 3 2 2 CD cord-015365-iqdi99pd 658 4 months month NNS cord-015365-iqdi99pd 658 5 ; ; : cord-015365-iqdi99pd 658 6 weighing weigh VBG cord-015365-iqdi99pd 658 7 approx approx NN cord-015365-iqdi99pd 658 8 . . . cord-015365-iqdi99pd 659 1 20 20 CD cord-015365-iqdi99pd 659 2 grams gram NNS cord-015365-iqdi99pd 659 3 ) ) -RRB- cord-015365-iqdi99pd 659 4 and and CC cord-015365-iqdi99pd 659 5 old old JJ cord-015365-iqdi99pd 659 6 ( ( -LRB- cord-015365-iqdi99pd 659 7 12 12 CD cord-015365-iqdi99pd 659 8 months month NNS cord-015365-iqdi99pd 659 9 ; ; : cord-015365-iqdi99pd 659 10 25 25 CD cord-015365-iqdi99pd 659 11 g g NN cord-015365-iqdi99pd 659 12 ) ) -RRB- cord-015365-iqdi99pd 659 13 recipients recipient NNS cord-015365-iqdi99pd 659 14 ( ( -LRB- cord-015365-iqdi99pd 659 15 C57BL/6 C57BL/6 NNP cord-015365-iqdi99pd 659 16 ) ) -RRB- cord-015365-iqdi99pd 659 17 were be VBD cord-015365-iqdi99pd 659 18 treated treat VBN cord-015365-iqdi99pd 659 19 with with IN cord-015365-iqdi99pd 659 20 3 3 CD cord-015365-iqdi99pd 659 21 or or CC cord-015365-iqdi99pd 659 22 1 1 CD cord-015365-iqdi99pd 659 23 Gy Gy NNP cord-015365-iqdi99pd 659 24 total total JJ cord-015365-iqdi99pd 659 25 body body NN cord-015365-iqdi99pd 659 26 irradiation irradiation NN cord-015365-iqdi99pd 659 27 ( ( -LRB- cord-015365-iqdi99pd 659 28 TBI TBI NNP cord-015365-iqdi99pd 659 29 , , , cord-015365-iqdi99pd 659 30 d-1 d-1 NNP cord-015365-iqdi99pd 659 31 ) ) -RRB- cord-015365-iqdi99pd 659 32 and and CC cord-015365-iqdi99pd 659 33 received receive VBD cord-015365-iqdi99pd 659 34 adjusted adjust VBN cord-015365-iqdi99pd 659 35 to to IN cord-015365-iqdi99pd 659 36 the the DT cord-015365-iqdi99pd 659 37 body body NN cord-015365-iqdi99pd 659 38 weight weight NN cord-015365-iqdi99pd 659 39 20Â10 20Â10 NNP cord-015365-iqdi99pd 659 40 6 6 CD cord-015365-iqdi99pd 659 41 and and CC cord-015365-iqdi99pd 659 42 25Â10 25â10 CD cord-015365-iqdi99pd 660 1 6 6 CD cord-015365-iqdi99pd 660 2 un un NNP cord-015365-iqdi99pd 660 3 - - HYPH cord-015365-iqdi99pd 660 4 separated separate VBN cord-015365-iqdi99pd 660 5 Balb Balb NNP cord-015365-iqdi99pd 660 6 / / SYM cord-015365-iqdi99pd 660 7 c c NN cord-015365-iqdi99pd 660 8 BM BM NNP cord-015365-iqdi99pd 660 9 cells cell NNS cord-015365-iqdi99pd 660 10 ( ( -LRB- cord-015365-iqdi99pd 660 11 d0 d0 NNP cord-015365-iqdi99pd 660 12 ) ) -RRB- cord-015365-iqdi99pd 660 13 and and CC cord-015365-iqdi99pd 660 14 co co JJ cord-015365-iqdi99pd 660 15 - - JJ cord-015365-iqdi99pd 660 16 stimulatory stimulatory JJ cord-015365-iqdi99pd 660 17 blockade blockade NN cord-015365-iqdi99pd 660 18 with with IN cord-015365-iqdi99pd 660 19 anti anti JJ cord-015365-iqdi99pd 660 20 - - JJ cord-015365-iqdi99pd 660 21 CD154 cd154 CD cord-015365-iqdi99pd 660 22 mAb mAb NNS cord-015365-iqdi99pd 660 23 ( ( -LRB- cord-015365-iqdi99pd 660 24 d0 d0 NNP cord-015365-iqdi99pd 660 25 ) ) -RRB- cord-015365-iqdi99pd 660 26 and and CC cord-015365-iqdi99pd 660 27 CTLA4Ig CTLA4Ig NNP cord-015365-iqdi99pd 661 1 ( ( -LRB- cord-015365-iqdi99pd 661 2 d d NN cord-015365-iqdi99pd 661 3 þ þ NNP cord-015365-iqdi99pd 661 4 2 2 CD cord-015365-iqdi99pd 661 5 ) ) -RRB- cord-015365-iqdi99pd 661 6 was be VBD cord-015365-iqdi99pd 661 7 administered administer VBN cord-015365-iqdi99pd 661 8 . . . cord-015365-iqdi99pd 662 1 Lymphocyte lymphocyte NN cord-015365-iqdi99pd 662 2 subsets subset NNS cord-015365-iqdi99pd 662 3 and and CC cord-015365-iqdi99pd 662 4 cytokine cytokine NN cord-015365-iqdi99pd 662 5 production production NN cord-015365-iqdi99pd 662 6 were be VBD cord-015365-iqdi99pd 662 7 compared compare VBN cord-015365-iqdi99pd 662 8 between between IN cord-015365-iqdi99pd 662 9 young young JJ cord-015365-iqdi99pd 662 10 and and CC cord-015365-iqdi99pd 662 11 old old JJ cord-015365-iqdi99pd 662 12 naïve naïve JJ cord-015365-iqdi99pd 662 13 mice mouse NNS cord-015365-iqdi99pd 662 14 and and CC cord-015365-iqdi99pd 662 15 multilineage multilineage NN cord-015365-iqdi99pd 662 16 chimerism chimerism NN cord-015365-iqdi99pd 662 17 was be VBD cord-015365-iqdi99pd 662 18 followed follow VBN cord-015365-iqdi99pd 662 19 by by IN cord-015365-iqdi99pd 662 20 flow flow NN cord-015365-iqdi99pd 662 21 cytometry cytometry NN cord-015365-iqdi99pd 662 22 . . . cord-015365-iqdi99pd 663 1 Results result NNS cord-015365-iqdi99pd 663 2 . . . cord-015365-iqdi99pd 664 1 Old old JJ cord-015365-iqdi99pd 664 2 mice mouse NNS cord-015365-iqdi99pd 664 3 contain contain VBP cord-015365-iqdi99pd 664 4 significantly significantly RB cord-015365-iqdi99pd 664 5 more more JJR cord-015365-iqdi99pd 664 6 CD4 CD4 NNP cord-015365-iqdi99pd 664 7 ( ( -LRB- cord-015365-iqdi99pd 664 8 p p NN cord-015365-iqdi99pd 664 9 < < XX cord-015365-iqdi99pd 664 10 0.05 0.05 CD cord-015365-iqdi99pd 664 11 ) ) -RRB- cord-015365-iqdi99pd 664 12 and and CC cord-015365-iqdi99pd 664 13 CD8 CD8 NNP cord-015365-iqdi99pd 664 14 ( ( -LRB- cord-015365-iqdi99pd 664 15 p p NN cord-015365-iqdi99pd 664 16 < < XX cord-015365-iqdi99pd 664 17 0.001 0.001 CD cord-015365-iqdi99pd 664 18 ) ) -RRB- cord-015365-iqdi99pd 664 19 memory memory NN cord-015365-iqdi99pd 664 20 T T NNP cord-015365-iqdi99pd 664 21 cells cell NNS cord-015365-iqdi99pd 664 22 ( ( -LRB- cord-015365-iqdi99pd 664 23 CD44highCD62Llow cd44highcd62llow NN cord-015365-iqdi99pd 664 24 ) ) -RRB- cord-015365-iqdi99pd 664 25 , , , cord-015365-iqdi99pd 664 26 early early RB cord-015365-iqdi99pd 664 27 activated activate VBN cord-015365-iqdi99pd 664 28 CD4 CD4 NNP cord-015365-iqdi99pd 664 29 T T NNP cord-015365-iqdi99pd 664 30 cells cell NNS cord-015365-iqdi99pd 665 1 ( ( -LRB- cord-015365-iqdi99pd 665 2 CD4 CD4 NNP cord-015365-iqdi99pd 665 3 þ þ NNP cord-015365-iqdi99pd 665 4 CD69 CD69 NNP cord-015365-iqdi99pd 665 5 þ þ NNP cord-015365-iqdi99pd 665 6 ; ; : cord-015365-iqdi99pd 665 7 p p NN cord-015365-iqdi99pd 665 8 < < XX cord-015365-iqdi99pd 665 9 0.01 0.01 CD cord-015365-iqdi99pd 665 10 ) ) -RRB- cord-015365-iqdi99pd 665 11 , , , cord-015365-iqdi99pd 665 12 less less JJR cord-015365-iqdi99pd 665 13 CD4 CD4 NNP cord-015365-iqdi99pd 665 14 and and CC cord-015365-iqdi99pd 665 15 CD8 CD8 NNP cord-015365-iqdi99pd 665 16 T T NNP cord-015365-iqdi99pd 665 17 cells cell NNS cord-015365-iqdi99pd 665 18 and and CC cord-015365-iqdi99pd 665 19 comparable comparable JJ cord-015365-iqdi99pd 665 20 amounts amount NNS cord-015365-iqdi99pd 665 21 of of IN cord-015365-iqdi99pd 665 22 regulatory regulatory JJ cord-015365-iqdi99pd 665 23 T t NN cord-015365-iqdi99pd 665 24 cells cell NNS cord-015365-iqdi99pd 665 25 ( ( -LRB- cord-015365-iqdi99pd 665 26 Tregs Tregs NNP cord-015365-iqdi99pd 665 27 ; ; : cord-015365-iqdi99pd 666 1 CD4 CD4 NNP cord-015365-iqdi99pd 666 2 þ þ NNP cord-015365-iqdi99pd 667 1 CD25 CD25 NNP cord-015365-iqdi99pd 667 2 þ þ CD cord-015365-iqdi99pd 667 3 FoxP3þ FoxP3þ NNP cord-015365-iqdi99pd 667 4 ; ; : cord-015365-iqdi99pd 668 1 p p NNP cord-015365-iqdi99pd 668 2 ¼ ¼ NNP cord-015365-iqdi99pd 668 3 n.s n.s NNP cord-015365-iqdi99pd 668 4 . . . cord-015365-iqdi99pd 669 1 vs. vs. FW cord-015365-iqdi99pd 669 2 young young JJ cord-015365-iqdi99pd 669 3 animals animal NNS cord-015365-iqdi99pd 669 4 ) ) -RRB- cord-015365-iqdi99pd 669 5 . . . cord-015365-iqdi99pd 670 1 Moreover moreover RB cord-015365-iqdi99pd 670 2 , , , cord-015365-iqdi99pd 670 3 older old JJR cord-015365-iqdi99pd 670 4 CD4 CD4 NNP cord-015365-iqdi99pd 670 5 and and CC cord-015365-iqdi99pd 670 6 CD8 CD8 NNP cord-015365-iqdi99pd 670 7 T T NNP cord-015365-iqdi99pd 670 8 cells cell NNS cord-015365-iqdi99pd 670 9 release release VBP cord-015365-iqdi99pd 670 10 more more JJR cord-015365-iqdi99pd 670 11 IFN-(CD4 IFN-(CD4 NNP cord-015365-iqdi99pd 670 12 : : : cord-015365-iqdi99pd 670 13 p p NN cord-015365-iqdi99pd 670 14 < < XX cord-015365-iqdi99pd 670 15 0.05 0.05 CD cord-015365-iqdi99pd 670 16 ) ) -RRB- cord-015365-iqdi99pd 670 17 , , , cord-015365-iqdi99pd 670 18 IL-2 IL-2 NNP cord-015365-iqdi99pd 670 19 ( ( -LRB- cord-015365-iqdi99pd 670 20 not not RB cord-015365-iqdi99pd 670 21 CD8 CD8 NNP cord-015365-iqdi99pd 670 22 T T NNP cord-015365-iqdi99pd 670 23 cells cell NNS cord-015365-iqdi99pd 670 24 ) ) -RRB- cord-015365-iqdi99pd 670 25 , , , cord-015365-iqdi99pd 670 26 IL-6 IL-6 NNP cord-015365-iqdi99pd 670 27 ( ( -LRB- cord-015365-iqdi99pd 670 28 CD4 CD4 NNP cord-015365-iqdi99pd 670 29 : : : cord-015365-iqdi99pd 670 30 p p NN cord-015365-iqdi99pd 670 31 < < XX cord-015365-iqdi99pd 670 32 0.05 0.05 CD cord-015365-iqdi99pd 670 33 ) ) -RRB- cord-015365-iqdi99pd 670 34 , , , cord-015365-iqdi99pd 670 35 IL-10 IL-10 NNP cord-015365-iqdi99pd 670 36 and and CC cord-015365-iqdi99pd 670 37 TNF- TNF- NNP cord-015365-iqdi99pd 670 38 . . . cord-015365-iqdi99pd 670 39 Chimerism chimerism NN cord-015365-iqdi99pd 670 40 developed develop VBD cord-015365-iqdi99pd 670 41 earlier early RBR cord-015365-iqdi99pd 670 42 in in IN cord-015365-iqdi99pd 670 43 old old JJ cord-015365-iqdi99pd 670 44 recipients recipient NNS cord-015365-iqdi99pd 670 45 : : : cord-015365-iqdi99pd 670 46 within within IN cord-015365-iqdi99pd 670 47 one one CD cord-015365-iqdi99pd 670 48 week week NN cord-015365-iqdi99pd 670 49 most most RBS cord-015365-iqdi99pd 670 50 older old JJR cord-015365-iqdi99pd 670 51 recipients recipient NNS cord-015365-iqdi99pd 670 52 became become VBD cord-015365-iqdi99pd 670 53 chimeric chimeric JJ cord-015365-iqdi99pd 670 54 following follow VBG cord-015365-iqdi99pd 670 55 an an DT cord-015365-iqdi99pd 670 56 irradiation irradiation NN cord-015365-iqdi99pd 670 57 with with IN cord-015365-iqdi99pd 670 58 3 3 CD cord-015365-iqdi99pd 670 59 Gy Gy NNP cord-015365-iqdi99pd 670 60 TBI TBI NNP cord-015365-iqdi99pd 670 61 and and CC cord-015365-iqdi99pd 670 62 co co JJ cord-015365-iqdi99pd 670 63 - - JJ cord-015365-iqdi99pd 670 64 stimulatory stimulatory JJ cord-015365-iqdi99pd 670 65 blockade blockade NN cord-015365-iqdi99pd 670 66 ( ( -LRB- cord-015365-iqdi99pd 670 67 17/18 17/18 CD cord-015365-iqdi99pd 670 68 vs. vs. IN cord-015365-iqdi99pd 670 69 9/18 9/18 CD cord-015365-iqdi99pd 670 70 chimeras chimera NNS cord-015365-iqdi99pd 670 71 , , , cord-015365-iqdi99pd 670 72 d d NNP cord-015365-iqdi99pd 670 73 þ þ NNP cord-015365-iqdi99pd 670 74 7 7 CD cord-015365-iqdi99pd 670 75 and and CC cord-015365-iqdi99pd 670 76 16/17 16/17 CD cord-015365-iqdi99pd 670 77 vs. vs. IN cord-015365-iqdi99pd 670 78 12/17 12/17 CD cord-015365-iqdi99pd 670 79 , , , cord-015365-iqdi99pd 670 80 d d NNP cord-015365-iqdi99pd 670 81 þ þ NNP cord-015365-iqdi99pd 670 82 14 14 CD cord-015365-iqdi99pd 670 83 ) ) -RRB- cord-015365-iqdi99pd 670 84 . . . cord-015365-iqdi99pd 671 1 Old old JJ cord-015365-iqdi99pd 671 2 recipients recipient NNS cord-015365-iqdi99pd 671 3 became become VBD cord-015365-iqdi99pd 671 4 even even RB cord-015365-iqdi99pd 671 5 chimeric chimeric JJ cord-015365-iqdi99pd 671 6 with with IN cord-015365-iqdi99pd 671 7 a a DT cord-015365-iqdi99pd 671 8 reduction reduction NN cord-015365-iqdi99pd 671 9 of of IN cord-015365-iqdi99pd 671 10 the the DT cord-015365-iqdi99pd 671 11 total total JJ cord-015365-iqdi99pd 671 12 body body NN cord-015365-iqdi99pd 671 13 irradiation irradiation NN cord-015365-iqdi99pd 671 14 to to IN cord-015365-iqdi99pd 671 15 1 1 CD cord-015365-iqdi99pd 671 16 Gy Gy NNP cord-015365-iqdi99pd 671 17 . . . cord-015365-iqdi99pd 672 1 In in IN cord-015365-iqdi99pd 672 2 sharp sharp JJ cord-015365-iqdi99pd 672 3 contrast contrast NN cord-015365-iqdi99pd 672 4 , , , cord-015365-iqdi99pd 672 5 none none NN cord-015365-iqdi99pd 672 6 of of IN cord-015365-iqdi99pd 672 7 the the DT cord-015365-iqdi99pd 672 8 young young JJ cord-015365-iqdi99pd 672 9 recipients recipient NNS cord-015365-iqdi99pd 672 10 became become VBD cord-015365-iqdi99pd 672 11 chimeric chimeric JJ cord-015365-iqdi99pd 672 12 under under IN cord-015365-iqdi99pd 672 13 those those DT cord-015365-iqdi99pd 672 14 conditions condition NNS cord-015365-iqdi99pd 672 15 ( ( -LRB- cord-015365-iqdi99pd 672 16 4/8 4/8 CD cord-015365-iqdi99pd 672 17 vs. vs. IN cord-015365-iqdi99pd 672 18 0/8 0/8 CD cord-015365-iqdi99pd 672 19 chimeras chimera NNS cord-015365-iqdi99pd 672 20 in in IN cord-015365-iqdi99pd 672 21 young young JJ cord-015365-iqdi99pd 672 22 recipient recipient NN cord-015365-iqdi99pd 672 23 , , , cord-015365-iqdi99pd 672 24 p p NN cord-015365-iqdi99pd 672 25 < < XX cord-015365-iqdi99pd 672 26 0.05 0.05 CD cord-015365-iqdi99pd 672 27 , , , cord-015365-iqdi99pd 672 28 d d NNP cord-015365-iqdi99pd 672 29 þ þ NNP cord-015365-iqdi99pd 672 30 30 30 CD cord-015365-iqdi99pd 672 31 ) ) -RRB- cord-015365-iqdi99pd 672 32 . . . cord-015365-iqdi99pd 673 1 Conclusions conclusion NNS cord-015365-iqdi99pd 673 2 . . . cord-015365-iqdi99pd 674 1 Recipient recipient NN cord-015365-iqdi99pd 674 2 age age NN cord-015365-iqdi99pd 674 3 is be VBZ cord-015365-iqdi99pd 674 4 linked link VBN cord-015365-iqdi99pd 674 5 to to IN cord-015365-iqdi99pd 674 6 a a DT cord-015365-iqdi99pd 674 7 faster fast JJR cord-015365-iqdi99pd 674 8 donor donor NN cord-015365-iqdi99pd 674 9 BM bm NN cord-015365-iqdi99pd 674 10 engraftment engraftment NN cord-015365-iqdi99pd 674 11 and and CC cord-015365-iqdi99pd 674 12 chimerism chimerism NN cord-015365-iqdi99pd 674 13 . . . cord-015365-iqdi99pd 675 1 Moreover moreover RB cord-015365-iqdi99pd 675 2 , , , cord-015365-iqdi99pd 675 3 chimerism chimerism NN cord-015365-iqdi99pd 675 4 is be VBZ cord-015365-iqdi99pd 675 5 attainable attainable JJ cord-015365-iqdi99pd 675 6 with with IN cord-015365-iqdi99pd 675 7 a a DT cord-015365-iqdi99pd 675 8 lower low JJR cord-015365-iqdi99pd 675 9 dose dose NN cord-015365-iqdi99pd 675 10 of of IN cord-015365-iqdi99pd 675 11 irradiation irradiation NN cord-015365-iqdi99pd 675 12 . . . cord-015365-iqdi99pd 676 1 Those those DT cord-015365-iqdi99pd 676 2 results result NNS cord-015365-iqdi99pd 676 3 support support VBP cord-015365-iqdi99pd 676 4 the the DT cord-015365-iqdi99pd 676 5 clinical clinical JJ cord-015365-iqdi99pd 676 6 relevance relevance NN cord-015365-iqdi99pd 676 7 of of IN cord-015365-iqdi99pd 676 8 the the DT cord-015365-iqdi99pd 676 9 chimerism chimerism NN cord-015365-iqdi99pd 676 10 strategy strategy NN cord-015365-iqdi99pd 676 11 for for IN cord-015365-iqdi99pd 676 12 tolerance tolerance NN cord-015365-iqdi99pd 676 13 induction induction NN cord-015365-iqdi99pd 676 14 . . . cord-015365-iqdi99pd 677 1 Background background NN cord-015365-iqdi99pd 677 2 . . . cord-015365-iqdi99pd 678 1 In in IN cord-015365-iqdi99pd 678 2 allogeneic allogeneic NN cord-015365-iqdi99pd 678 3 bone bone NN cord-015365-iqdi99pd 678 4 marrow marrow NN cord-015365-iqdi99pd 678 5 transplantation transplantation NN cord-015365-iqdi99pd 678 6 ( ( -LRB- cord-015365-iqdi99pd 678 7 BMT BMT NNP cord-015365-iqdi99pd 678 8 ) ) -RRB- cord-015365-iqdi99pd 678 9 donor donor NN cord-015365-iqdi99pd 678 10 T t NN cord-015365-iqdi99pd 678 11 cells cell NNS cord-015365-iqdi99pd 678 12 have have VBP cord-015365-iqdi99pd 678 13 pleiotropic pleiotropic JJ cord-015365-iqdi99pd 678 14 effects effect NNS cord-015365-iqdi99pd 678 15 . . . cord-015365-iqdi99pd 679 1 Surprisingly surprisingly RB cord-015365-iqdi99pd 679 2 , , , cord-015365-iqdi99pd 679 3 cotransplanting cotransplante VBG cord-015365-iqdi99pd 679 4 high high JJ cord-015365-iqdi99pd 679 5 doses dose NNS cord-015365-iqdi99pd 679 6 of of IN cord-015365-iqdi99pd 679 7 donor donor NN cord-015365-iqdi99pd 679 8 T t NN cord-015365-iqdi99pd 679 9 cells cell NNS cord-015365-iqdi99pd 679 10 with with IN cord-015365-iqdi99pd 679 11 donor donor NN cord-015365-iqdi99pd 679 12 BM bm NN cord-015365-iqdi99pd 679 13 causes cause VBZ cord-015365-iqdi99pd 679 14 rejection rejection NN cord-015365-iqdi99pd 679 15 of of IN cord-015365-iqdi99pd 679 16 donor donor NN cord-015365-iqdi99pd 679 17 BM BM NNP cord-015365-iqdi99pd 679 18 despite despite IN cord-015365-iqdi99pd 679 19 costimulation costimulation NN cord-015365-iqdi99pd 679 20 blockade blockade NN cord-015365-iqdi99pd 679 21 . . . cord-015365-iqdi99pd 680 1 Therefore therefore RB cord-015365-iqdi99pd 680 2 , , , cord-015365-iqdi99pd 680 3 in in IN cord-015365-iqdi99pd 680 4 the the DT cord-015365-iqdi99pd 680 5 present present JJ cord-015365-iqdi99pd 680 6 study study NN cord-015365-iqdi99pd 680 7 we -PRON- PRP cord-015365-iqdi99pd 680 8 investigate investigate VBP cord-015365-iqdi99pd 680 9 the the DT cord-015365-iqdi99pd 680 10 molecular molecular JJ cord-015365-iqdi99pd 680 11 mechanisms mechanism NNS cord-015365-iqdi99pd 680 12 responsible responsible JJ cord-015365-iqdi99pd 680 13 for for IN cord-015365-iqdi99pd 680 14 this this DT cord-015365-iqdi99pd 680 15 seemingly seemingly RB cord-015365-iqdi99pd 680 16 paradoxical paradoxical JJ cord-015365-iqdi99pd 680 17 phenomenon phenomenon NN cord-015365-iqdi99pd 680 18 . . . cord-015365-iqdi99pd 681 1 Methods method NNS cord-015365-iqdi99pd 681 2 . . . cord-015365-iqdi99pd 682 1 Recipients recipient NNS cord-015365-iqdi99pd 682 2 ( ( -LRB- cord-015365-iqdi99pd 682 3 C57BL/6 C57BL/6 NNP cord-015365-iqdi99pd 682 4 ) ) -RRB- cord-015365-iqdi99pd 682 5 were be VBD cord-015365-iqdi99pd 682 6 treated treat VBN cord-015365-iqdi99pd 682 7 with with IN cord-015365-iqdi99pd 682 8 3 3 CD cord-015365-iqdi99pd 682 9 Gy Gy NNP cord-015365-iqdi99pd 682 10 TBI TBI NNP cord-015365-iqdi99pd 682 11 ( ( -LRB- cord-015365-iqdi99pd 682 12 d-1 d-1 NNP cord-015365-iqdi99pd 682 13 ) ) -RRB- cord-015365-iqdi99pd 682 14 and and CC cord-015365-iqdi99pd 682 15 received receive VBD cord-015365-iqdi99pd 682 16 approximately approximately RB cord-015365-iqdi99pd 682 17 20Â106 20â106 CD cord-015365-iqdi99pd 682 18 unseparated unseparated JJ cord-015365-iqdi99pd 682 19 Balb Balb NNP cord-015365-iqdi99pd 682 20 / / SYM cord-015365-iqdi99pd 682 21 c c NN cord-015365-iqdi99pd 682 22 BM BM NNP cord-015365-iqdi99pd 682 23 cells cell NNS cord-015365-iqdi99pd 682 24 ( ( -LRB- cord-015365-iqdi99pd 682 25 d0 d0 NNP cord-015365-iqdi99pd 682 26 ) ) -RRB- cord-015365-iqdi99pd 682 27 and and CC cord-015365-iqdi99pd 682 28 costimulation costimulation NN cord-015365-iqdi99pd 682 29 blockers blocker NNS cord-015365-iqdi99pd 682 30 anti anti NNP cord-015365-iqdi99pd 682 31 - - JJ cord-015365-iqdi99pd 682 32 CD154 CD154 NNP cord-015365-iqdi99pd 682 33 mAb mAb NNS cord-015365-iqdi99pd 682 34 ( ( -LRB- cord-015365-iqdi99pd 682 35 d0 d0 NNP cord-015365-iqdi99pd 682 36 ) ) -RRB- cord-015365-iqdi99pd 682 37 and and CC cord-015365-iqdi99pd 682 38 CTLA4Ig CTLA4Ig NNP cord-015365-iqdi99pd 682 39 ( ( -LRB- cord-015365-iqdi99pd 682 40 d d NN cord-015365-iqdi99pd 682 41 þ þ NNP cord-015365-iqdi99pd 682 42 2 2 CD cord-015365-iqdi99pd 682 43 ) ) -RRB- cord-015365-iqdi99pd 682 44 . . . cord-015365-iqdi99pd 683 1 30Â10 30â10 CD cord-015365-iqdi99pd 683 2 6 6 CD cord-015365-iqdi99pd 684 1 Balb Balb NNP cord-015365-iqdi99pd 684 2 / / SYM cord-015365-iqdi99pd 684 3 c c NN cord-015365-iqdi99pd 684 4 , , , cord-015365-iqdi99pd 684 5 CB6F1 CB6F1 NNP cord-015365-iqdi99pd 684 6 ( ( -LRB- cord-015365-iqdi99pd 684 7 Balb Balb NNP cord-015365-iqdi99pd 684 8 / / SYM cord-015365-iqdi99pd 684 9 cÂB6 cÂB6 NNP cord-015365-iqdi99pd 684 10 ) ) -RRB- cord-015365-iqdi99pd 684 11 , , , cord-015365-iqdi99pd 684 12 irradiated irradiate VBN cord-015365-iqdi99pd 685 1 Balb Balb NNP cord-015365-iqdi99pd 685 2 / / SYM cord-015365-iqdi99pd 685 3 c c NN cord-015365-iqdi99pd 685 4 or or CC cord-015365-iqdi99pd 685 5 C3H c3h IN cord-015365-iqdi99pd 685 6 CD4 CD4 NNP cord-015365-iqdi99pd 685 7 T T NNP cord-015365-iqdi99pd 685 8 cells cell NNS cord-015365-iqdi99pd 685 9 ( ( -LRB- cord-015365-iqdi99pd 685 10 isolated isolate VBN cord-015365-iqdi99pd 685 11 by by IN cord-015365-iqdi99pd 685 12 MACS mac NNS cord-015365-iqdi99pd 685 13 ) ) -RRB- cord-015365-iqdi99pd 685 14 were be VBD cord-015365-iqdi99pd 685 15 co co VBN cord-015365-iqdi99pd 685 16 - - VBN cord-015365-iqdi99pd 685 17 transplanted transplant VBN cord-015365-iqdi99pd 685 18 in in IN cord-015365-iqdi99pd 685 19 addition addition NN cord-015365-iqdi99pd 685 20 . . . cord-015365-iqdi99pd 686 1 Groups group NNS cord-015365-iqdi99pd 686 2 either either CC cord-015365-iqdi99pd 686 3 received receive VBD cord-015365-iqdi99pd 686 4 anti anti JJ cord-015365-iqdi99pd 686 5 - - NNP cord-015365-iqdi99pd 686 6 IL-6 il-6 JJ cord-015365-iqdi99pd 686 7 , , , cord-015365-iqdi99pd 686 8 anti anti JJ cord-015365-iqdi99pd 686 9 - - JJ cord-015365-iqdi99pd 686 10 IFN- ifn- JJ cord-015365-iqdi99pd 686 11 , , , cord-015365-iqdi99pd 686 12 anti anti JJ cord-015365-iqdi99pd 686 13 - - JJ cord-015365-iqdi99pd 686 14 LFA1 lfa1 JJ cord-015365-iqdi99pd 686 15 mAb mAb NNS cord-015365-iqdi99pd 686 16 or or CC cord-015365-iqdi99pd 686 17 rapamycin rapamycin NNS cord-015365-iqdi99pd 686 18 . . . cord-015365-iqdi99pd 687 1 Multilineage multilineage NN cord-015365-iqdi99pd 687 2 chimerism chimerism NN cord-015365-iqdi99pd 687 3 was be VBD cord-015365-iqdi99pd 687 4 followed follow VBN cord-015365-iqdi99pd 687 5 by by IN cord-015365-iqdi99pd 687 6 flow flow NN cord-015365-iqdi99pd 687 7 cytometry cytometry NN cord-015365-iqdi99pd 687 8 and and CC cord-015365-iqdi99pd 687 9 cytokine cytokine NN cord-015365-iqdi99pd 687 10 release release NN cord-015365-iqdi99pd 687 11 was be VBD cord-015365-iqdi99pd 687 12 analyzed analyze VBN cord-015365-iqdi99pd 687 13 . . . cord-015365-iqdi99pd 688 1 Results result NNS cord-015365-iqdi99pd 688 2 . . . cord-015365-iqdi99pd 689 1 Co co NN cord-015365-iqdi99pd 689 2 - - NN cord-015365-iqdi99pd 689 3 transplantation transplantation NN cord-015365-iqdi99pd 689 4 of of IN cord-015365-iqdi99pd 689 5 30Â10 30â10 CD cord-015365-iqdi99pd 689 6 6 6 CD cord-015365-iqdi99pd 689 7 CD4 CD4 NNP cord-015365-iqdi99pd 689 8 T T NNP cord-015365-iqdi99pd 689 9 cells cell NNS cord-015365-iqdi99pd 689 10 but but CC cord-015365-iqdi99pd 689 11 not not RB cord-015365-iqdi99pd 689 12 CD8 CD8 NNP cord-015365-iqdi99pd 689 13 T T NNP cord-015365-iqdi99pd 689 14 cells cell NNS cord-015365-iqdi99pd 689 15 triggered trigger VBD cord-015365-iqdi99pd 689 16 rapid rapid JJ cord-015365-iqdi99pd 689 17 BM BM NNP cord-015365-iqdi99pd 689 18 rejection rejection NN cord-015365-iqdi99pd 689 19 of of IN cord-015365-iqdi99pd 689 20 donor donor NN cord-015365-iqdi99pd 689 21 BM BM NNP cord-015365-iqdi99pd 689 22 under under IN cord-015365-iqdi99pd 689 23 costimulation costimulation NN cord-015365-iqdi99pd 689 24 blockade blockade NN cord-015365-iqdi99pd 689 25 within within IN cord-015365-iqdi99pd 689 26 one one CD cord-015365-iqdi99pd 689 27 week week NN cord-015365-iqdi99pd 689 28 in in IN cord-015365-iqdi99pd 689 29 an an DT cord-015365-iqdi99pd 689 30 otherwise otherwise RB cord-015365-iqdi99pd 689 31 successful successful JJ cord-015365-iqdi99pd 689 32 protocol protocol NN cord-015365-iqdi99pd 689 33 ( ( -LRB- cord-015365-iqdi99pd 689 34 0/13 0/13 CD cord-015365-iqdi99pd 689 35 vs. vs. IN cord-015365-iqdi99pd 689 36 17/20 17/20 CD cord-015365-iqdi99pd 689 37 chimeras chimera NNS cord-015365-iqdi99pd 689 38 , , , cord-015365-iqdi99pd 689 39 p p NN cord-015365-iqdi99pd 689 40 < < XX cord-015365-iqdi99pd 689 41 0.001 0.001 CD cord-015365-iqdi99pd 689 42 ) ) -RRB- cord-015365-iqdi99pd 689 43 . . . cord-015365-iqdi99pd 690 1 The the DT cord-015365-iqdi99pd 690 2 levels level NNS cord-015365-iqdi99pd 690 3 of of IN cord-015365-iqdi99pd 690 4 IL-6 IL-6 NNP cord-015365-iqdi99pd 690 5 , , , cord-015365-iqdi99pd 690 6 IFN- IFN- NNP cord-015365-iqdi99pd 690 7 , , , cord-015365-iqdi99pd 690 8 IL-17A il-17a NN cord-015365-iqdi99pd 690 9 ( ( -LRB- cord-015365-iqdi99pd 690 10 p p NN cord-015365-iqdi99pd 690 11 < < XX cord-015365-iqdi99pd 690 12 0.05 0.05 CD cord-015365-iqdi99pd 690 13 ) ) -RRB- cord-015365-iqdi99pd 690 14 and and CC cord-015365-iqdi99pd 690 15 TGF TGF NNP cord-015365-iqdi99pd 690 16 - - , cord-015365-iqdi99pd 690 17 were be VBD cord-015365-iqdi99pd 690 18 found find VBN cord-015365-iqdi99pd 690 19 to to TO cord-015365-iqdi99pd 690 20 be be VB cord-015365-iqdi99pd 690 21 higher high JJR cord-015365-iqdi99pd 690 22 in in IN cord-015365-iqdi99pd 690 23 mice mouse NNS cord-015365-iqdi99pd 690 24 treated treat VBN cord-015365-iqdi99pd 690 25 with with IN cord-015365-iqdi99pd 690 26 additional additional JJ cord-015365-iqdi99pd 690 27 donor donor NN cord-015365-iqdi99pd 690 28 T t NN cord-015365-iqdi99pd 690 29 cells cell NNS cord-015365-iqdi99pd 690 30 . . . cord-015365-iqdi99pd 691 1 The the DT cord-015365-iqdi99pd 691 2 neutralization neutralization NN cord-015365-iqdi99pd 691 3 of of IN cord-015365-iqdi99pd 691 4 IL-6 IL-6 NNP cord-015365-iqdi99pd 691 5 , , , cord-015365-iqdi99pd 691 6 but but CC cord-015365-iqdi99pd 691 7 not not RB cord-015365-iqdi99pd 691 8 of of IN cord-015365-iqdi99pd 691 9 IFN IFN NNP cord-015365-iqdi99pd 691 10 - - HYPH cord-015365-iqdi99pd 691 11 resulted result VBD cord-015365-iqdi99pd 691 12 in in IN cord-015365-iqdi99pd 691 13 a a DT cord-015365-iqdi99pd 691 14 significantly significantly RB cord-015365-iqdi99pd 691 15 higher high JJR cord-015365-iqdi99pd 691 16 rate rate NN cord-015365-iqdi99pd 691 17 of of IN cord-015365-iqdi99pd 691 18 chimerism chimerism NN cord-015365-iqdi99pd 691 19 induction induction NN cord-015365-iqdi99pd 691 20 compared compare VBN cord-015365-iqdi99pd 691 21 to to IN cord-015365-iqdi99pd 691 22 controls control NNS cord-015365-iqdi99pd 691 23 ( ( -LRB- cord-015365-iqdi99pd 691 24 5/7 5/7 CD cord-015365-iqdi99pd 691 25 vs. vs. IN cord-015365-iqdi99pd 691 26 0/5 0/5 CD cord-015365-iqdi99pd 691 27 chimeras chimera NNS cord-015365-iqdi99pd 691 28 ; ; : cord-015365-iqdi99pd 691 29 p p NN cord-015365-iqdi99pd 691 30 < < XX cord-015365-iqdi99pd 691 31 0.05 0.05 CD cord-015365-iqdi99pd 691 32 ) ) -RRB- cord-015365-iqdi99pd 691 33 . . . cord-015365-iqdi99pd 692 1 The the DT cord-015365-iqdi99pd 692 2 injection injection NN cord-015365-iqdi99pd 692 3 of of IN cord-015365-iqdi99pd 692 4 CB6F1 CB6F1 NNP cord-015365-iqdi99pd 692 5 or or CC cord-015365-iqdi99pd 692 6 irradiated irradiate VBN cord-015365-iqdi99pd 692 7 Balb Balb NNP cord-015365-iqdi99pd 692 8 / / SYM cord-015365-iqdi99pd 692 9 c c NN cord-015365-iqdi99pd 692 10 CD4 CD4 NNP cord-015365-iqdi99pd 692 11 T T NNP cord-015365-iqdi99pd 692 12 cells cell NNS cord-015365-iqdi99pd 692 13 did do VBD cord-015365-iqdi99pd 692 14 not not RB cord-015365-iqdi99pd 692 15 abrogate abrogate VB cord-015365-iqdi99pd 692 16 chimerism chimerism NN cord-015365-iqdi99pd 692 17 ( ( -LRB- cord-015365-iqdi99pd 692 18 5/6 5/6 CD cord-015365-iqdi99pd 692 19 and and CC cord-015365-iqdi99pd 692 20 4/5 4/5 CD cord-015365-iqdi99pd 692 21 vs. vs. NN cord-015365-iqdi99pd 692 22 0/4 0/4 CD cord-015365-iqdi99pd 692 23 chimeras chimera NNS cord-015365-iqdi99pd 692 24 with with IN cord-015365-iqdi99pd 692 25 Balb Balb NNP cord-015365-iqdi99pd 692 26 / / SYM cord-015365-iqdi99pd 692 27 c c NN cord-015365-iqdi99pd 692 28 T t NN cord-015365-iqdi99pd 692 29 cells cell NNS cord-015365-iqdi99pd 692 30 ; ; : cord-015365-iqdi99pd 692 31 p p NN cord-015365-iqdi99pd 692 32 < < XX cord-015365-iqdi99pd 692 33 0.05 0.05 CD cord-015365-iqdi99pd 692 34 ) ) -RRB- cord-015365-iqdi99pd 692 35 , , , cord-015365-iqdi99pd 692 36 whereas whereas IN cord-015365-iqdi99pd 692 37 C3H c3h CD cord-015365-iqdi99pd 692 38 CD4 CD4 NNP cord-015365-iqdi99pd 692 39 T T NNP cord-015365-iqdi99pd 692 40 cells cell NNS cord-015365-iqdi99pd 692 41 induced induce VBN cord-015365-iqdi99pd 692 42 BM BM NNP cord-015365-iqdi99pd 692 43 rejection rejection NN cord-015365-iqdi99pd 692 44 ( ( -LRB- cord-015365-iqdi99pd 692 45 0/5 0/5 CD cord-015365-iqdi99pd 692 46 vs. vs. NN cord-015365-iqdi99pd 692 47 9/9 9/9 CD cord-015365-iqdi99pd 692 48 chimeras chimera NNS cord-015365-iqdi99pd 692 49 BMT BMT NNP cord-015365-iqdi99pd 692 50 , , , cord-015365-iqdi99pd 692 51 p p NN cord-015365-iqdi99pd 692 52 < < XX cord-015365-iqdi99pd 692 53 0.001 0.001 CD cord-015365-iqdi99pd 692 54 ) ) -RRB- cord-015365-iqdi99pd 692 55 . . . cord-015365-iqdi99pd 693 1 The the DT cord-015365-iqdi99pd 693 2 additional additional JJ cord-015365-iqdi99pd 693 3 treatment treatment NN cord-015365-iqdi99pd 693 4 with with IN cord-015365-iqdi99pd 693 5 rapamycin rapamycin NN cord-015365-iqdi99pd 693 6 or or CC cord-015365-iqdi99pd 693 7 anti anti JJ cord-015365-iqdi99pd 693 8 - - JJ cord-015365-iqdi99pd 693 9 LFA1 LFA1 NNP cord-015365-iqdi99pd 693 10 overcame overcome VBD cord-015365-iqdi99pd 693 11 the the DT cord-015365-iqdi99pd 693 12 negative negative JJ cord-015365-iqdi99pd 693 13 effect effect NN cord-015365-iqdi99pd 693 14 of of IN cord-015365-iqdi99pd 693 15 donor donor NN cord-015365-iqdi99pd 693 16 T t NN cord-015365-iqdi99pd 693 17 cell cell NN cord-015365-iqdi99pd 693 18 injection injection NN cord-015365-iqdi99pd 693 19 ( ( -LRB- cord-015365-iqdi99pd 693 20 5/5 5/5 CD cord-015365-iqdi99pd 693 21 and and CC cord-015365-iqdi99pd 693 22 6/6 6/6 CD cord-015365-iqdi99pd 693 23 vs. vs. IN cord-015365-iqdi99pd 693 24 0/4 0/4 CD cord-015365-iqdi99pd 693 25 chimeras chimera NNS cord-015365-iqdi99pd 693 26 ; ; : cord-015365-iqdi99pd 693 27 p p NN cord-015365-iqdi99pd 693 28 < < XX cord-015365-iqdi99pd 693 29 0.01 0.01 CD cord-015365-iqdi99pd 693 30 ) ) -RRB- cord-015365-iqdi99pd 693 31 . . . cord-015365-iqdi99pd 694 1 Conclusions conclusion NNS cord-015365-iqdi99pd 694 2 . . . cord-015365-iqdi99pd 695 1 The the DT cord-015365-iqdi99pd 695 2 abrogation abrogation NN cord-015365-iqdi99pd 695 3 of of IN cord-015365-iqdi99pd 695 4 BM BM NNP cord-015365-iqdi99pd 695 5 engraftment engraftment NN cord-015365-iqdi99pd 695 6 through through IN cord-015365-iqdi99pd 695 7 cotransplantation cotransplantation NN cord-015365-iqdi99pd 695 8 of of IN cord-015365-iqdi99pd 695 9 donor donor NN cord-015365-iqdi99pd 695 10 CD4 CD4 NNP cord-015365-iqdi99pd 695 11 T T NNP cord-015365-iqdi99pd 695 12 cells cell NNS cord-015365-iqdi99pd 695 13 involves involve VBZ cord-015365-iqdi99pd 695 14 IL-6 IL-6 NNP cord-015365-iqdi99pd 695 15 , , , cord-015365-iqdi99pd 695 16 requires require VBZ cord-015365-iqdi99pd 695 17 proliferative proliferative JJ cord-015365-iqdi99pd 695 18 capacity capacity NN cord-015365-iqdi99pd 695 19 of of IN cord-015365-iqdi99pd 695 20 the the DT cord-015365-iqdi99pd 695 21 co co NN cord-015365-iqdi99pd 695 22 - - JJ cord-015365-iqdi99pd 695 23 transplanted transplanted JJ cord-015365-iqdi99pd 695 24 T T NNP cord-015365-iqdi99pd 695 25 cells cell NNS cord-015365-iqdi99pd 695 26 and and CC cord-015365-iqdi99pd 695 27 needs need VBZ cord-015365-iqdi99pd 695 28 to to TO cord-015365-iqdi99pd 695 29 recognize recognize VB cord-015365-iqdi99pd 695 30 the the DT cord-015365-iqdi99pd 695 31 recipient recipient NN cord-015365-iqdi99pd 695 32 as as IN cord-015365-iqdi99pd 695 33 allogeneic allogeneic NN cord-015365-iqdi99pd 695 34 . . . cord-015365-iqdi99pd 696 1 Neutralisation Neutralisation NNP cord-015365-iqdi99pd 696 2 of of IN cord-015365-iqdi99pd 696 3 IL-6 IL-6 NNP cord-015365-iqdi99pd 696 4 , , , cord-015365-iqdi99pd 696 5 rapamycin rapamycin NN cord-015365-iqdi99pd 696 6 and and CC cord-015365-iqdi99pd 696 7 anti anti JJ cord-015365-iqdi99pd 696 8 - - JJ cord-015365-iqdi99pd 696 9 LFA1 LFA1 NNP cord-015365-iqdi99pd 696 10 overcome overcome VB cord-015365-iqdi99pd 696 11 the the DT cord-015365-iqdi99pd 696 12 effect effect NN cord-015365-iqdi99pd 696 13 of of IN cord-015365-iqdi99pd 696 14 co co JJ cord-015365-iqdi99pd 696 15 - - JJ cord-015365-iqdi99pd 696 16 transplanted transplanted JJ cord-015365-iqdi99pd 696 17 donor donor NN cord-015365-iqdi99pd 696 18 CD4 CD4 NNP cord-015365-iqdi99pd 696 19 T T NNP cord-015365-iqdi99pd 696 20 cells cell NNS cord-015365-iqdi99pd 696 21 and and CC cord-015365-iqdi99pd 696 22 offer offer VBP cord-015365-iqdi99pd 696 23 potential potential JJ cord-015365-iqdi99pd 696 24 targets target NNS cord-015365-iqdi99pd 696 25 for for IN cord-015365-iqdi99pd 696 26 therapeutic therapeutic JJ cord-015365-iqdi99pd 696 27 intervention intervention NN cord-015365-iqdi99pd 696 28 in in IN cord-015365-iqdi99pd 696 29 costimulation costimulation NN cord-015365-iqdi99pd 696 30 blockade blockade NN cord-015365-iqdi99pd 696 31 - - HYPH cord-015365-iqdi99pd 696 32 resistant resistant JJ cord-015365-iqdi99pd 696 33 rejection rejection NN cord-015365-iqdi99pd 696 34 . . . cord-015365-iqdi99pd 696 35 _SP cord-015365-iqdi99pd 697 1 Background background NN cord-015365-iqdi99pd 697 2 . . . cord-015365-iqdi99pd 698 1 Mixed mixed JJ cord-015365-iqdi99pd 698 2 chimerism chimerism NN cord-015365-iqdi99pd 698 3 is be VBZ cord-015365-iqdi99pd 698 4 an an DT cord-015365-iqdi99pd 698 5 effective effective JJ cord-015365-iqdi99pd 698 6 strategy strategy NN cord-015365-iqdi99pd 698 7 for for IN cord-015365-iqdi99pd 698 8 the the DT cord-015365-iqdi99pd 698 9 induction induction NN cord-015365-iqdi99pd 698 10 of of IN cord-015365-iqdi99pd 698 11 transplantation transplantation NN cord-015365-iqdi99pd 698 12 tolerance tolerance NN cord-015365-iqdi99pd 698 13 , , , cord-015365-iqdi99pd 698 14 however however RB cord-015365-iqdi99pd 698 15 , , , cord-015365-iqdi99pd 698 16 translation translation NN cord-015365-iqdi99pd 698 17 from from IN cord-015365-iqdi99pd 698 18 murine murine JJ cord-015365-iqdi99pd 698 19 models model NNS cord-015365-iqdi99pd 698 20 to to IN cord-015365-iqdi99pd 698 21 the the DT cord-015365-iqdi99pd 698 22 clinical clinical JJ cord-015365-iqdi99pd 698 23 setting setting NN cord-015365-iqdi99pd 698 24 is be VBZ cord-015365-iqdi99pd 698 25 challenging challenging JJ cord-015365-iqdi99pd 698 26 . . . cord-015365-iqdi99pd 699 1 One one CD cord-015365-iqdi99pd 699 2 hurdle hurdle NN cord-015365-iqdi99pd 699 3 is be VBZ cord-015365-iqdi99pd 699 4 the the DT cord-015365-iqdi99pd 699 5 high high JJ cord-015365-iqdi99pd 699 6 frequency frequency NN cord-015365-iqdi99pd 699 7 of of IN cord-015365-iqdi99pd 699 8 alloreactive alloreactive JJ cord-015365-iqdi99pd 699 9 memory memory NN cord-015365-iqdi99pd 699 10 T T NNP cord-015365-iqdi99pd 699 11 - - HYPH cord-015365-iqdi99pd 699 12 cells cell NNS cord-015365-iqdi99pd 699 13 ( ( -LRB- cord-015365-iqdi99pd 699 14 Tmem Tmem NNP cord-015365-iqdi99pd 699 15 ) ) -RRB- cord-015365-iqdi99pd 699 16 found find VBN cord-015365-iqdi99pd 699 17 in in IN cord-015365-iqdi99pd 699 18 the the DT cord-015365-iqdi99pd 699 19 ( ( -LRB- cord-015365-iqdi99pd 699 20 pre)clinical pre)clinical JJ cord-015365-iqdi99pd 699 21 setting setting NN cord-015365-iqdi99pd 699 22 , , , cord-015365-iqdi99pd 699 23 which which WDT cord-015365-iqdi99pd 699 24 is be VBZ cord-015365-iqdi99pd 699 25 not not RB cord-015365-iqdi99pd 699 26 present present JJ cord-015365-iqdi99pd 699 27 to to IN cord-015365-iqdi99pd 699 28 a a DT cord-015365-iqdi99pd 699 29 similar similar JJ cord-015365-iqdi99pd 699 30 degree degree NN cord-015365-iqdi99pd 699 31 in in IN cord-015365-iqdi99pd 699 32 mouse mouse NN cord-015365-iqdi99pd 699 33 models model NNS cord-015365-iqdi99pd 699 34 . . . cord-015365-iqdi99pd 700 1 To to TO cord-015365-iqdi99pd 700 2 better well RBR cord-015365-iqdi99pd 700 3 model model VB cord-015365-iqdi99pd 700 4 this this DT cord-015365-iqdi99pd 700 5 clinical clinical JJ cord-015365-iqdi99pd 700 6 reality reality NN cord-015365-iqdi99pd 700 7 , , , cord-015365-iqdi99pd 700 8 we -PRON- PRP cord-015365-iqdi99pd 700 9 have have VBP cord-015365-iqdi99pd 700 10 developed develop VBN cord-015365-iqdi99pd 700 11 a a DT cord-015365-iqdi99pd 700 12 murine murine JJ cord-015365-iqdi99pd 700 13 model model NN cord-015365-iqdi99pd 700 14 in in IN cord-015365-iqdi99pd 700 15 which which WDT cord-015365-iqdi99pd 700 16 the the DT cord-015365-iqdi99pd 700 17 transfer transfer NN cord-015365-iqdi99pd 700 18 of of IN cord-015365-iqdi99pd 700 19 3Â10 3â10 CD cord-015365-iqdi99pd 700 20 7 7 CD cord-015365-iqdi99pd 700 21 T t NN cord-015365-iqdi99pd 700 22 - - HYPH cord-015365-iqdi99pd 700 23 cells cell NNS cord-015365-iqdi99pd 700 24 from from IN cord-015365-iqdi99pd 700 25 sensitized sensitize VBN cord-015365-iqdi99pd 700 26 mice mouse NNS cord-015365-iqdi99pd 700 27 inhibits inhibit VBZ cord-015365-iqdi99pd 700 28 the the DT cord-015365-iqdi99pd 700 29 induction induction NN cord-015365-iqdi99pd 700 30 of of IN cord-015365-iqdi99pd 700 31 chimerism chimerism NN cord-015365-iqdi99pd 700 32 and and CC cord-015365-iqdi99pd 700 33 tolerance tolerance NN cord-015365-iqdi99pd 700 34 in in IN cord-015365-iqdi99pd 700 35 a a DT cord-015365-iqdi99pd 700 36 well well RB cord-015365-iqdi99pd 700 37 - - HYPH cord-015365-iqdi99pd 700 38 characterized characterize VBN cord-015365-iqdi99pd 700 39 costimulation costimulation NN cord-015365-iqdi99pd 700 40 blockade blockade NN cord-015365-iqdi99pd 700 41 - - HYPH cord-015365-iqdi99pd 700 42 based base VBN cord-015365-iqdi99pd 700 43 bone bone NN cord-015365-iqdi99pd 700 44 marrow marrow NN cord-015365-iqdi99pd 700 45 transplantation transplantation NN cord-015365-iqdi99pd 700 46 ( ( -LRB- cord-015365-iqdi99pd 700 47 BMT BMT NNP cord-015365-iqdi99pd 700 48 ) ) -RRB- cord-015365-iqdi99pd 700 49 model model NN cord-015365-iqdi99pd 700 50 . . . cord-015365-iqdi99pd 701 1 Here here RB cord-015365-iqdi99pd 701 2 , , , cord-015365-iqdi99pd 701 3 we -PRON- PRP cord-015365-iqdi99pd 701 4 evaluated evaluate VBD cord-015365-iqdi99pd 701 5 whether whether IN cord-015365-iqdi99pd 701 6 treatment treatment NN cord-015365-iqdi99pd 701 7 with with IN cord-015365-iqdi99pd 701 8 clinically clinically RB cord-015365-iqdi99pd 701 9 approved approve VBN cord-015365-iqdi99pd 701 10 drugs drug NNS cord-015365-iqdi99pd 701 11 ( ( -LRB- cord-015365-iqdi99pd 701 12 rapamycin rapamycin NNS cord-015365-iqdi99pd 701 13 , , , cord-015365-iqdi99pd 701 14 anti anti JJ cord-015365-iqdi99pd 701 15 - - JJ cord-015365-iqdi99pd 701 16 LFA-1mAb lfa-1mab JJ cord-015365-iqdi99pd 701 17 ) ) -RRB- cord-015365-iqdi99pd 701 18 can can MD cord-015365-iqdi99pd 701 19 overcome overcome VB cord-015365-iqdi99pd 701 20 costimulationresistant costimulationresistant NN cord-015365-iqdi99pd 701 21 rejection rejection NN cord-015365-iqdi99pd 701 22 triggered trigger VBN cord-015365-iqdi99pd 701 23 by by IN cord-015365-iqdi99pd 701 24 memory memory NN cord-015365-iqdi99pd 701 25 cells cell NNS cord-015365-iqdi99pd 701 26 and and CC cord-015365-iqdi99pd 701 27 tried try VBD cord-015365-iqdi99pd 701 28 to to TO cord-015365-iqdi99pd 701 29 gain gain VB cord-015365-iqdi99pd 701 30 insight insight NN cord-015365-iqdi99pd 701 31 into into IN cord-015365-iqdi99pd 701 32 the the DT cord-015365-iqdi99pd 701 33 underlying underlie VBG cord-015365-iqdi99pd 701 34 mechanisms mechanism NNS cord-015365-iqdi99pd 701 35 . . . cord-015365-iqdi99pd 702 1 Methods method NNS cord-015365-iqdi99pd 702 2 . . . cord-015365-iqdi99pd 703 1 T T NNP cord-015365-iqdi99pd 703 2 - - HYPH cord-015365-iqdi99pd 703 3 cells cell NNS cord-015365-iqdi99pd 703 4 sensitized sensitize VBN cord-015365-iqdi99pd 703 5 towards towards IN cord-015365-iqdi99pd 703 6 donor donor NN cord-015365-iqdi99pd 703 7 ( ( -LRB- cord-015365-iqdi99pd 703 8 3Â10 3â10 CD cord-015365-iqdi99pd 703 9 7 7 CD cord-015365-iqdi99pd 703 10 Tmemenriched Tmemenriched NNP cord-015365-iqdi99pd 703 11 T t NN cord-015365-iqdi99pd 703 12 - - HYPH cord-015365-iqdi99pd 703 13 cells cell NNS cord-015365-iqdi99pd 703 14 ) ) -RRB- cord-015365-iqdi99pd 703 15 were be VBD cord-015365-iqdi99pd 703 16 adoptively adoptively RB cord-015365-iqdi99pd 703 17 transferred transfer VBN cord-015365-iqdi99pd 703 18 into into IN cord-015365-iqdi99pd 703 19 groups group NNS cord-015365-iqdi99pd 703 20 of of IN cord-015365-iqdi99pd 703 21 naïve naïve JJ cord-015365-iqdi99pd 703 22 B6 b6 NN cord-015365-iqdi99pd 703 23 mice mouse NNS cord-015365-iqdi99pd 703 24 prior prior RB cord-015365-iqdi99pd 703 25 to to IN cord-015365-iqdi99pd 703 26 BMT BMT NNP cord-015365-iqdi99pd 703 27 ( ( -LRB- cord-015365-iqdi99pd 703 28 d-7 d-7 NNS cord-015365-iqdi99pd 703 29 ) ) -RRB- cord-015365-iqdi99pd 703 30 . . . cord-015365-iqdi99pd 704 1 BMT BMT NNP cord-015365-iqdi99pd 704 2 recipients recipient NNS cord-015365-iqdi99pd 704 3 received receive VBD cord-015365-iqdi99pd 704 4 1Gy 1gy JJ cord-015365-iqdi99pd 704 5 total total JJ cord-015365-iqdi99pd 704 6 body body NN cord-015365-iqdi99pd 704 7 irradiation irradiation NN cord-015365-iqdi99pd 704 8 ( ( -LRB- cord-015365-iqdi99pd 704 9 d-1 d-1 NNP cord-015365-iqdi99pd 704 10 ) ) -RRB- cord-015365-iqdi99pd 704 11 , , , cord-015365-iqdi99pd 704 12 20Â10 20â10 CD cord-015365-iqdi99pd 704 13 6 6 CD cord-015365-iqdi99pd 704 14 fully fully RB cord-015365-iqdi99pd 704 15 mismatched mismatch VBN cord-015365-iqdi99pd 704 16 Balb Balb NNP cord-015365-iqdi99pd 704 17 / / SYM cord-015365-iqdi99pd 704 18 c c NN cord-015365-iqdi99pd 704 19 bone bone NN cord-015365-iqdi99pd 704 20 marrow marrow NN cord-015365-iqdi99pd 704 21 cells cell NNS cord-015365-iqdi99pd 704 22 ( ( -LRB- cord-015365-iqdi99pd 704 23 d0 d0 NNP cord-015365-iqdi99pd 704 24 ) ) -RRB- cord-015365-iqdi99pd 704 25 and and CC cord-015365-iqdi99pd 704 26 costimulation costimulation NN cord-015365-iqdi99pd 704 27 - - HYPH cord-015365-iqdi99pd 704 28 blockade blockade NN cord-015365-iqdi99pd 704 29 consisting consisting NN cord-015365-iqdi99pd 704 30 of of IN cord-015365-iqdi99pd 704 31 anti anti JJ cord-015365-iqdi99pd 704 32 - - JJ cord-015365-iqdi99pd 704 33 CD154mAb cd154mab JJ cord-015365-iqdi99pd 704 34 ( ( -LRB- cord-015365-iqdi99pd 704 35 1 1 CD cord-015365-iqdi99pd 704 36 mg mg NN cord-015365-iqdi99pd 704 37 , , , cord-015365-iqdi99pd 704 38 d0 d0 NNP cord-015365-iqdi99pd 704 39 ) ) -RRB- cord-015365-iqdi99pd 704 40 and and CC cord-015365-iqdi99pd 704 41 CTLA4Ig CTLA4Ig NNP cord-015365-iqdi99pd 704 42 ( ( -LRB- cord-015365-iqdi99pd 704 43 0.5 0.5 CD cord-015365-iqdi99pd 704 44 mg mg NNP cord-015365-iqdi99pd 704 45 , , , cord-015365-iqdi99pd 704 46 d d NNP cord-015365-iqdi99pd 704 47 þ þ NNP cord-015365-iqdi99pd 704 48 2 2 CD cord-015365-iqdi99pd 704 49 ) ) -RRB- cord-015365-iqdi99pd 704 50 . . . cord-015365-iqdi99pd 705 1 Groups group NNS cord-015365-iqdi99pd 705 2 additionally additionally RB cord-015365-iqdi99pd 705 3 received receive VBD cord-015365-iqdi99pd 705 4 rapamycin rapamycin NNS cord-015365-iqdi99pd 705 5 ( ( -LRB- cord-015365-iqdi99pd 705 6 0.1 0.1 CD cord-015365-iqdi99pd 705 7 mg mg NNP cord-015365-iqdi99pd 705 8 / / SYM cord-015365-iqdi99pd 705 9 d d XX cord-015365-iqdi99pd 705 10 , , , cord-015365-iqdi99pd 705 11 d-1/0/2 d-1/0/2 NNP cord-015365-iqdi99pd 705 12 ) ) -RRB- cord-015365-iqdi99pd 705 13 or or CC cord-015365-iqdi99pd 705 14 anti anti JJ cord-015365-iqdi99pd 705 15 - - JJ cord-015365-iqdi99pd 705 16 LFA-1mAb lfa-1mab JJ cord-015365-iqdi99pd 705 17 ( ( -LRB- cord-015365-iqdi99pd 705 18 0.1 0.1 CD cord-015365-iqdi99pd 705 19 mg mg NNP cord-015365-iqdi99pd 705 20 / / SYM cord-015365-iqdi99pd 705 21 d d NNP cord-015365-iqdi99pd 705 22 , , , cord-015365-iqdi99pd 705 23 d-1/2 d-1/2 NNP cord-015365-iqdi99pd 705 24 ) ) -RRB- cord-015365-iqdi99pd 705 25 . . . cord-015365-iqdi99pd 706 1 Multilineage multilineage NN cord-015365-iqdi99pd 706 2 chimerism chimerism NN cord-015365-iqdi99pd 706 3 and and CC cord-015365-iqdi99pd 706 4 deletion deletion NN cord-015365-iqdi99pd 706 5 of of IN cord-015365-iqdi99pd 706 6 donor donor NN cord-015365-iqdi99pd 706 7 - - HYPH cord-015365-iqdi99pd 706 8 reactive reactive JJ cord-015365-iqdi99pd 706 9 T t NN cord-015365-iqdi99pd 706 10 - - HYPH cord-015365-iqdi99pd 706 11 cells cell NNS cord-015365-iqdi99pd 706 12 were be VBD cord-015365-iqdi99pd 706 13 followed follow VBN cord-015365-iqdi99pd 706 14 by by IN cord-015365-iqdi99pd 706 15 flow flow NN cord-015365-iqdi99pd 706 16 - - HYPH cord-015365-iqdi99pd 706 17 cytometry cytometry NN cord-015365-iqdi99pd 706 18 and and CC cord-015365-iqdi99pd 706 19 in in IN cord-015365-iqdi99pd 706 20 vitro vitro FW cord-015365-iqdi99pd 706 21 tolerance tolerance NN cord-015365-iqdi99pd 706 22 was be VBD cord-015365-iqdi99pd 706 23 assessed assess VBN cord-015365-iqdi99pd 706 24 by by IN cord-015365-iqdi99pd 706 25 MLR MLR NNP cord-015365-iqdi99pd 706 26 . . . cord-015365-iqdi99pd 707 1 Transferred transfer VBN cord-015365-iqdi99pd 707 2 T T NNP cord-015365-iqdi99pd 707 3 - - HYPH cord-015365-iqdi99pd 707 4 cells cell NNS cord-015365-iqdi99pd 707 5 were be VBD cord-015365-iqdi99pd 707 6 followed follow VBN cord-015365-iqdi99pd 707 7 in in IN cord-015365-iqdi99pd 707 8 vivo vivo NN cord-015365-iqdi99pd 707 9 using use VBG cord-015365-iqdi99pd 707 10 CD45.1/2 cd45.1/2 NN cord-015365-iqdi99pd 707 11 alleles allele NNS cord-015365-iqdi99pd 707 12 as as IN cord-015365-iqdi99pd 707 13 congeneic congeneic JJ cord-015365-iqdi99pd 707 14 markers marker NNS cord-015365-iqdi99pd 707 15 in in IN cord-015365-iqdi99pd 707 16 peripheral peripheral JJ cord-015365-iqdi99pd 707 17 blood blood NN cord-015365-iqdi99pd 707 18 ( ( -LRB- cord-015365-iqdi99pd 707 19 d-2/12 d-2/12 NNP cord-015365-iqdi99pd 707 20 ) ) -RRB- cord-015365-iqdi99pd 707 21 and and CC cord-015365-iqdi99pd 707 22 lymphoid lymphoid JJ cord-015365-iqdi99pd 707 23 organs organ NNS cord-015365-iqdi99pd 707 24 ( ( -LRB- cord-015365-iqdi99pd 707 25 d7 d7 NNP cord-015365-iqdi99pd 707 26 ) ) -RRB- cord-015365-iqdi99pd 707 27 . . . cord-015365-iqdi99pd 708 1 IFNgamma ifngamma JJ cord-015365-iqdi99pd 708 2 - - HYPH cord-015365-iqdi99pd 708 3 production production NN cord-015365-iqdi99pd 708 4 upon upon IN cord-015365-iqdi99pd 708 5 stimulation stimulation NN cord-015365-iqdi99pd 708 6 with with IN cord-015365-iqdi99pd 708 7 donor donor NN cord-015365-iqdi99pd 708 8 antigen antigen NN cord-015365-iqdi99pd 708 9 was be VBD cord-015365-iqdi99pd 708 10 measured measure VBN cord-015365-iqdi99pd 708 11 by by IN cord-015365-iqdi99pd 708 12 ELISPOT ELISPOT NNP cord-015365-iqdi99pd 708 13 and and CC cord-015365-iqdi99pd 708 14 intracellular intracellular JJ cord-015365-iqdi99pd 708 15 flow flow NN cord-015365-iqdi99pd 708 16 - - HYPH cord-015365-iqdi99pd 708 17 cytometry cytometry NN cord-015365-iqdi99pd 708 18 . . . cord-015365-iqdi99pd 709 1 Results result NNS cord-015365-iqdi99pd 709 2 . . . cord-015365-iqdi99pd 710 1 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 710 2 and and CC cord-015365-iqdi99pd 710 3 anti anti NNP cord-015365-iqdi99pd 710 4 - - NN cord-015365-iqdi99pd 710 5 LFA-1 LFA-1 NNP cord-015365-iqdi99pd 710 6 were be VBD cord-015365-iqdi99pd 710 7 able able JJ cord-015365-iqdi99pd 710 8 to to TO cord-015365-iqdi99pd 710 9 overcome overcome VB cord-015365-iqdi99pd 710 10 costimulation costimulation NN cord-015365-iqdi99pd 710 11 - - HYPH cord-015365-iqdi99pd 710 12 blockade blockade NN cord-015365-iqdi99pd 710 13 resistant resistant JJ cord-015365-iqdi99pd 710 14 rejection rejection NN cord-015365-iqdi99pd 710 15 and and CC cord-015365-iqdi99pd 710 16 induced induce VBN cord-015365-iqdi99pd 710 17 stable stable JJ cord-015365-iqdi99pd 710 18 multi multi JJ cord-015365-iqdi99pd 710 19 - - JJ cord-015365-iqdi99pd 710 20 lineage lineage JJ cord-015365-iqdi99pd 710 21 chimerism chimerism NN cord-015365-iqdi99pd 710 22 in in IN cord-015365-iqdi99pd 710 23 pre pre JJ cord-015365-iqdi99pd 710 24 - - JJ cord-015365-iqdi99pd 710 25 sensitized sensitize VBN cord-015365-iqdi99pd 710 26 recipients recipient NNS cord-015365-iqdi99pd 710 27 ( ( -LRB- cord-015365-iqdi99pd 710 28 0/7 0/7 CD cord-015365-iqdi99pd 710 29 control control NN cord-015365-iqdi99pd 710 30 vs. vs. IN cord-015365-iqdi99pd 710 31 7/7 7/7 CD cord-015365-iqdi99pd 710 32 rapa rapa NN cord-015365-iqdi99pd 710 33 , , , cord-015365-iqdi99pd 710 34 p p NN cord-015365-iqdi99pd 710 35 < < XX cord-015365-iqdi99pd 710 36 0.001 0.001 CD cord-015365-iqdi99pd 710 37 ; ; : cord-015365-iqdi99pd 710 38 3/7 3/7 CD cord-015365-iqdi99pd 710 39 anti anti NNP cord-015365-iqdi99pd 710 40 - - NNP cord-015365-iqdi99pd 710 41 LFA-1 LFA-1 NNP cord-015365-iqdi99pd 710 42 , , , cord-015365-iqdi99pd 710 43 p p NN cord-015365-iqdi99pd 710 44 ¼ ¼ CD cord-015365-iqdi99pd 710 45 0.2 0.2 CD cord-015365-iqdi99pd 710 46 ; ; : cord-015365-iqdi99pd 710 47 representative representative NN cord-015365-iqdi99pd 710 48 for for IN cord-015365-iqdi99pd 710 49 multiple multiple JJ cord-015365-iqdi99pd 710 50 experiments experiment NNS cord-015365-iqdi99pd 710 51 ) ) -RRB- cord-015365-iqdi99pd 710 52 . . . cord-015365-iqdi99pd 711 1 Chimeras chimera NNS cord-015365-iqdi99pd 711 2 showed show VBD cord-015365-iqdi99pd 711 3 central central JJ cord-015365-iqdi99pd 711 4 and and CC cord-015365-iqdi99pd 711 5 peripheral peripheral JJ cord-015365-iqdi99pd 711 6 deletion deletion NN cord-015365-iqdi99pd 711 7 of of IN cord-015365-iqdi99pd 711 8 donor donor NN cord-015365-iqdi99pd 711 9 - - HYPH cord-015365-iqdi99pd 711 10 reactive reactive JJ cord-015365-iqdi99pd 711 11 T t NN cord-015365-iqdi99pd 711 12 - - HYPH cord-015365-iqdi99pd 711 13 cells cell NNS cord-015365-iqdi99pd 711 14 and and CC cord-015365-iqdi99pd 711 15 donor donor NN cord-015365-iqdi99pd 711 16 - - HYPH cord-015365-iqdi99pd 711 17 specific specific JJ cord-015365-iqdi99pd 711 18 hyporesponsiveness hyporesponsiveness NN cord-015365-iqdi99pd 711 19 in in IN cord-015365-iqdi99pd 711 20 vitro vitro FW cord-015365-iqdi99pd 711 21 . . . cord-015365-iqdi99pd 712 1 The the DT cord-015365-iqdi99pd 712 2 frequency frequency NN cord-015365-iqdi99pd 712 3 of of IN cord-015365-iqdi99pd 712 4 transferred transfer VBN cord-015365-iqdi99pd 712 5 T T NNP cord-015365-iqdi99pd 712 6 - - HYPH cord-015365-iqdi99pd 712 7 cells cell NNS cord-015365-iqdi99pd 712 8 decreased decrease VBD cord-015365-iqdi99pd 712 9 over over IN cord-015365-iqdi99pd 712 10 time time NN cord-015365-iqdi99pd 712 11 , , , cord-015365-iqdi99pd 712 12 but but CC cord-015365-iqdi99pd 712 13 less less RBR cord-015365-iqdi99pd 712 14 so so RB cord-015365-iqdi99pd 712 15 in in IN cord-015365-iqdi99pd 712 16 the the DT cord-015365-iqdi99pd 712 17 rapamycin rapamycin NN cord-015365-iqdi99pd 712 18 - - HYPH cord-015365-iqdi99pd 712 19 treated treat VBN cord-015365-iqdi99pd 712 20 group group NN cord-015365-iqdi99pd 712 21 . . . cord-015365-iqdi99pd 713 1 IFNgamma IFNgamma NNP cord-015365-iqdi99pd 713 2 - - HYPH cord-015365-iqdi99pd 713 3 production production NN cord-015365-iqdi99pd 713 4 was be VBD cord-015365-iqdi99pd 713 5 reduced reduce VBN cord-015365-iqdi99pd 713 6 by by IN cord-015365-iqdi99pd 713 7 rapa rapa NN cord-015365-iqdi99pd 713 8 or or CC cord-015365-iqdi99pd 713 9 anti anti NNP cord-015365-iqdi99pd 713 10 - - NNP cord-015365-iqdi99pd 713 11 LFA-1 LFA-1 NNP cord-015365-iqdi99pd 713 12 treatment treatment NN cord-015365-iqdi99pd 713 13 . . . cord-015365-iqdi99pd 714 1 Conclusions conclusion NNS cord-015365-iqdi99pd 714 2 . . . cord-015365-iqdi99pd 715 1 Rapamycin Rapamycin NNP cord-015365-iqdi99pd 715 2 and and CC cord-015365-iqdi99pd 715 3 anti anti NNP cord-015365-iqdi99pd 715 4 - - NN cord-015365-iqdi99pd 715 5 LFA-1 LFA-1 NNP cord-015365-iqdi99pd 715 6 overcome overcome VB cord-015365-iqdi99pd 715 7 the the DT cord-015365-iqdi99pd 715 8 additional additional JJ cord-015365-iqdi99pd 715 9 T t NN cord-015365-iqdi99pd 715 10 - - HYPH cord-015365-iqdi99pd 715 11 memory memory NN cord-015365-iqdi99pd 715 12 - - HYPH cord-015365-iqdi99pd 715 13 cell cell NN cord-015365-iqdi99pd 715 14 barrier barrier NN cord-015365-iqdi99pd 715 15 for for IN cord-015365-iqdi99pd 715 16 tolerance tolerance NN cord-015365-iqdi99pd 715 17 induction induction NN cord-015365-iqdi99pd 715 18 , , , cord-015365-iqdi99pd 715 19 although although IN cord-015365-iqdi99pd 715 20 rapamycin rapamycin NNP cord-015365-iqdi99pd 715 21 seems seem VBZ cord-015365-iqdi99pd 715 22 to to TO cord-015365-iqdi99pd 715 23 be be VB cord-015365-iqdi99pd 715 24 more more RBR cord-015365-iqdi99pd 715 25 potent potent JJ cord-015365-iqdi99pd 715 26 in in IN cord-015365-iqdi99pd 715 27 Tmem Tmem NNP cord-015365-iqdi99pd 715 28 tolerization tolerization NN cord-015365-iqdi99pd 715 29 in in IN cord-015365-iqdi99pd 715 30 this this DT cord-015365-iqdi99pd 715 31 model model NN cord-015365-iqdi99pd 715 32 . . . cord-015365-iqdi99pd 716 1 The the DT cord-015365-iqdi99pd 716 2 trend trend NN cord-015365-iqdi99pd 716 3 that that DT cord-015365-iqdi99pd 716 4 elimination elimination NN cord-015365-iqdi99pd 716 5 of of IN cord-015365-iqdi99pd 716 6 Tmem Tmem NNP cord-015365-iqdi99pd 716 7 is be VBZ cord-015365-iqdi99pd 716 8 lower low JJR cord-015365-iqdi99pd 716 9 in in IN cord-015365-iqdi99pd 716 10 the the DT cord-015365-iqdi99pd 716 11 rapamycin rapamycin NN cord-015365-iqdi99pd 716 12 - - HYPH cord-015365-iqdi99pd 716 13 treated treat VBN cord-015365-iqdi99pd 716 14 group group NN cord-015365-iqdi99pd 716 15 and and CC cord-015365-iqdi99pd 716 16 central central JJ cord-015365-iqdi99pd 716 17 deletion deletion NN cord-015365-iqdi99pd 716 18 is be VBZ cord-015365-iqdi99pd 716 19 more more RBR cord-015365-iqdi99pd 716 20 pronounced pronounced JJ cord-015365-iqdi99pd 716 21 early early RB cord-015365-iqdi99pd 716 22 after after IN cord-015365-iqdi99pd 716 23 BMT BMT NNP cord-015365-iqdi99pd 716 24 suggests suggest VBZ cord-015365-iqdi99pd 716 25 different different JJ cord-015365-iqdi99pd 716 26 mechanisms mechanism NNS cord-015365-iqdi99pd 716 27 for for IN cord-015365-iqdi99pd 716 28 Tmem Tmem NNP cord-015365-iqdi99pd 716 29 tolerization tolerization NN cord-015365-iqdi99pd 716 30 . . . cord-015365-iqdi99pd 717 1 Lunchsymposium Lunchsymposium NNP cord-015365-iqdi99pd 717 2 Virusinfektionen Virusinfektionen NNP cord-015365-iqdi99pd 717 3 in in IN cord-015365-iqdi99pd 717 4 der der NNP cord-015365-iqdi99pd 717 5 Organ Organ NNP cord-015365-iqdi99pd 717 6 - - HYPH cord-015365-iqdi99pd 717 7 und und NNP cord-015365-iqdi99pd 717 8 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 717 9 035 035 CD cord-015365-iqdi99pd 718 1 Diagnostik Diagnostik NNP cord-015365-iqdi99pd 718 2 von von NNP cord-015365-iqdi99pd 718 3 Virusinfektionen Virusinfektionen NNP cord-015365-iqdi99pd 718 4 in in IN cord-015365-iqdi99pd 718 5 Transplantationspatienten Transplantationspatienten NNP cord-015365-iqdi99pd 718 6 Patienten Patienten NNP cord-015365-iqdi99pd 719 1 nach nach NNP cord-015365-iqdi99pd 720 1 Organ organ NN cord-015365-iqdi99pd 720 2 - - HYPH cord-015365-iqdi99pd 720 3 oder oder NNP cord-015365-iqdi99pd 720 4 Knochenmarkstransplantationen Knochenmarkstransplantationen NNP cord-015365-iqdi99pd 720 5 werden werden NNP cord-015365-iqdi99pd 720 6 immunsuppressiv immunsuppressiv NNP cord-015365-iqdi99pd 720 7 behandelt behandelt NNP cord-015365-iqdi99pd 721 1 und und NNP cord-015365-iqdi99pd 721 2 weisen weisen NNP cord-015365-iqdi99pd 721 3 daher daher NNP cord-015365-iqdi99pd 721 4 ein ein NNP cord-015365-iqdi99pd 721 5 anderes anderes NNP cord-015365-iqdi99pd 721 6 Spektrum Spektrum NNP cord-015365-iqdi99pd 721 7 von von NNP cord-015365-iqdi99pd 721 8 potentiell potentiell NNP cord-015365-iqdi99pd 721 9 gefährlichen gefährlichen NNP cord-015365-iqdi99pd 722 1 Virusinfektionen Virusinfektionen NNP cord-015365-iqdi99pd 722 2 auf auf NNP cord-015365-iqdi99pd 722 3 als als NN cord-015365-iqdi99pd 722 4 immunkompetente immunkompetente JJ cord-015365-iqdi99pd 722 5 Personen Personen NNP cord-015365-iqdi99pd 722 6 . . . cord-015365-iqdi99pd 723 1 Vor Vor NNP cord-015365-iqdi99pd 723 2 allem allem NNP cord-015365-iqdi99pd 723 3 Viren Viren NNP cord-015365-iqdi99pd 723 4 , , , cord-015365-iqdi99pd 723 5 die die VBP cord-015365-iqdi99pd 723 6 i -PRON- PRP cord-015365-iqdi99pd 723 7 m be VBP cord-015365-iqdi99pd 723 8 normalen normalen NNP cord-015365-iqdi99pd 723 9 Wirt Wirt NNP cord-015365-iqdi99pd 723 10 nur nur NNP cord-015365-iqdi99pd 723 11 leichte leichte NNP cord-015365-iqdi99pd 723 12 oder oder NNP cord-015365-iqdi99pd 723 13 asymptomatische asymptomatische NNP cord-015365-iqdi99pd 724 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 724 2 verursachen verursachen NNP cord-015365-iqdi99pd 725 1 und und IN cord-015365-iqdi99pd 725 2 latent latent JJ cord-015365-iqdi99pd 726 1 i -PRON- PRP cord-015365-iqdi99pd 726 2 m be VBP cord-015365-iqdi99pd 726 3 Organismus Organismus NNP cord-015365-iqdi99pd 726 4 verbleiben verbleiben NN cord-015365-iqdi99pd 726 5 , , , cord-015365-iqdi99pd 726 6 wie wie NNP cord-015365-iqdi99pd 726 7 Herpesviren Herpesviren NNP cord-015365-iqdi99pd 726 8 ( ( -LRB- cord-015365-iqdi99pd 726 9 Zytomegalievirus Zytomegalievirus NNP cord-015365-iqdi99pd 726 10 , , , cord-015365-iqdi99pd 726 11 Epstein Epstein NNP cord-015365-iqdi99pd 726 12 - - HYPH cord-015365-iqdi99pd 726 13 Barr Barr NNP cord-015365-iqdi99pd 726 14 Virus Virus NNP cord-015365-iqdi99pd 726 15 etc etc NN cord-015365-iqdi99pd 726 16 . . . cord-015365-iqdi99pd 726 17 ) ) -RRB- cord-015365-iqdi99pd 727 1 oder oder NNP cord-015365-iqdi99pd 727 2 auch auch NNP cord-015365-iqdi99pd 727 3 Polyomaviren Polyomaviren NNP cord-015365-iqdi99pd 727 4 ( ( -LRB- cord-015365-iqdi99pd 727 5 BK- BK- NNP cord-015365-iqdi99pd 727 6 , , , cord-015365-iqdi99pd 727 7 JC JC NNP cord-015365-iqdi99pd 727 8 - - HYPH cord-015365-iqdi99pd 727 9 Virus Virus NNP cord-015365-iqdi99pd 727 10 ) ) -RRB- cord-015365-iqdi99pd 727 11 , , . cord-015365-iqdi99pd 728 1 können können UH cord-015365-iqdi99pd 728 2 unter unter NNP cord-015365-iqdi99pd 728 3 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 728 4 hoch hoch NNP cord-015365-iqdi99pd 728 5 replizieren replizieren NNP cord-015365-iqdi99pd 729 1 und und IN cord-015365-iqdi99pd 729 2 zu zu NNP cord-015365-iqdi99pd 729 3 schweren schweren NNP cord-015365-iqdi99pd 729 4 und und XX cord-015365-iqdi99pd 730 1 potentiell potentiell NNP cord-015365-iqdi99pd 730 2 tödlichen tödlichen NNP cord-015365-iqdi99pd 730 3 Infektionen Infektionen NNP cord-015365-iqdi99pd 730 4 führen führen NNP cord-015365-iqdi99pd 730 5 . . . cord-015365-iqdi99pd 731 1 Um um UH cord-015365-iqdi99pd 732 1 schwere schwere NNP cord-015365-iqdi99pd 732 2 Infektionen Infektionen NNP cord-015365-iqdi99pd 732 3 oder oder NNP cord-015365-iqdi99pd 732 4 Reaktivierungen Reaktivierungen NNP cord-015365-iqdi99pd 732 5 durch durch NNP cord-015365-iqdi99pd 732 6 verschiedene verschiedene NN cord-015365-iqdi99pd 732 7 Viren Viren NNP cord-015365-iqdi99pd 732 8 zu zu NNP cord-015365-iqdi99pd 732 9 verhindern verhindern NNP cord-015365-iqdi99pd 732 10 , , , cord-015365-iqdi99pd 732 11 wird wird NNP cord-015365-iqdi99pd 732 12 heute heute NNP cord-015365-iqdi99pd 732 13 routinemäßig routinemäßig NNP cord-015365-iqdi99pd 732 14 in in IN cord-015365-iqdi99pd 732 15 regelmäßigen regelmäßigen NNP cord-015365-iqdi99pd 732 16 Abständen Abständen NNP cord-015365-iqdi99pd 733 1 i -PRON- PRP cord-015365-iqdi99pd 733 2 m be VBP cord-015365-iqdi99pd 733 3 Verlauf Verlauf NNP cord-015365-iqdi99pd 733 4 nach nach NNP cord-015365-iqdi99pd 733 5 Transplantation Transplantation NNP cord-015365-iqdi99pd 733 6 der der NN cord-015365-iqdi99pd 733 7 direkte direkte NNP cord-015365-iqdi99pd 733 8 und und XX cord-015365-iqdi99pd 734 1 quantitative quantitative JJ cord-015365-iqdi99pd 734 2 Nachweis Nachweis NNP cord-015365-iqdi99pd 734 3 verschiedener verschiedener NNP cord-015365-iqdi99pd 734 4 Viren Viren NNP cord-015365-iqdi99pd 734 5 ( ( -LRB- cord-015365-iqdi99pd 734 6 vor vor NNP cord-015365-iqdi99pd 734 7 allem allem NNP cord-015365-iqdi99pd 734 8 von von NNP cord-015365-iqdi99pd 734 9 Zytomegalievirus Zytomegalievirus NNP cord-015365-iqdi99pd 734 10 ) ) -RRB- cord-015365-iqdi99pd 734 11 mittels mittels NNP cord-015365-iqdi99pd 734 12 PCR PCR NNP cord-015365-iqdi99pd 734 13 i -PRON- PRP cord-015365-iqdi99pd 734 14 m be VBP cord-015365-iqdi99pd 734 15 Blut Blut NNP cord-015365-iqdi99pd 734 16 , , , cord-015365-iqdi99pd 734 17 aber aber NNP cord-015365-iqdi99pd 734 18 auch auch NNP cord-015365-iqdi99pd 734 19 in in IN cord-015365-iqdi99pd 734 20 verschiedenen verschiedenen NNP cord-015365-iqdi99pd 734 21 anderen anderen NNP cord-015365-iqdi99pd 734 22 Patientenmaterialien Patientenmaterialien NNP cord-015365-iqdi99pd 734 23 durchgeführt durchgeführt NN cord-015365-iqdi99pd 734 24 . . . cord-015365-iqdi99pd 735 1 Ziel Ziel NNP cord-015365-iqdi99pd 735 2 der der NNP cord-015365-iqdi99pd 735 3 Virusdiagnostik Virusdiagnostik NNP cord-015365-iqdi99pd 736 1 ist ist NNP cord-015365-iqdi99pd 736 2 es es NNP cord-015365-iqdi99pd 736 3 hier hier NNP cord-015365-iqdi99pd 736 4 nicht nicht NNP cord-015365-iqdi99pd 737 1 so so RB cord-015365-iqdi99pd 737 2 sehr sehr NNP cord-015365-iqdi99pd 737 3 eine eine NNP cord-015365-iqdi99pd 737 4 klinisch klinisch FW cord-015365-iqdi99pd 737 5 relevante relevante NNP cord-015365-iqdi99pd 737 6 Virusinfektion Virusinfektion NNP cord-015365-iqdi99pd 737 7 nachzuweisen nachzuweisen NNP cord-015365-iqdi99pd 737 8 , , , cord-015365-iqdi99pd 738 1 sondern sondern NNP cord-015365-iqdi99pd 738 2 vielmehr vielmehr NNP cord-015365-iqdi99pd 738 3 das das NNP cord-015365-iqdi99pd 738 4 Vorhanden Vorhanden NNP cord-015365-iqdi99pd 738 5 - - HYPH cord-015365-iqdi99pd 738 6 sein sein NNP cord-015365-iqdi99pd 739 1 einer einer NNP cord-015365-iqdi99pd 739 2 signifikanten signifikanten NNP cord-015365-iqdi99pd 739 3 Virusreplikation Virusreplikation NNP cord-015365-iqdi99pd 739 4 frühzeitig frühzeitig NN cord-015365-iqdi99pd 739 5 , , , cord-015365-iqdi99pd 740 1 noch noch NNP cord-015365-iqdi99pd 740 2 vor vor NNP cord-015365-iqdi99pd 741 1 Krankheitsbeginn Krankheitsbeginn NNP cord-015365-iqdi99pd 741 2 zu zu NNP cord-015365-iqdi99pd 741 3 erkennen erkennen NNP cord-015365-iqdi99pd 741 4 . . . cord-015365-iqdi99pd 742 1 Das Das NNP cord-015365-iqdi99pd 742 2 ist ist NNP cord-015365-iqdi99pd 742 3 dann dann NNP cord-015365-iqdi99pd 742 4 auch auch NNP cord-015365-iqdi99pd 742 5 die die VBP cord-015365-iqdi99pd 742 6 Basis Basis NNP cord-015365-iqdi99pd 742 7 für für NN cord-015365-iqdi99pd 742 8 die die JJ cord-015365-iqdi99pd 742 9 " " `` cord-015365-iqdi99pd 742 10 präemptive präemptive JJ cord-015365-iqdi99pd 742 11 " " '' cord-015365-iqdi99pd 742 12 antivirale antivirale JJ cord-015365-iqdi99pd 742 13 Therapie Therapie NNP cord-015365-iqdi99pd 742 14 , , , cord-015365-iqdi99pd 742 15 die die VB cord-015365-iqdi99pd 742 16 gegeben gegeben NNP cord-015365-iqdi99pd 742 17 wird wird NNP cord-015365-iqdi99pd 742 18 , , , cord-015365-iqdi99pd 742 19 wenn wenn NNP cord-015365-iqdi99pd 742 20 die die VBP cord-015365-iqdi99pd 742 21 Viruslast Viruslast NNP cord-015365-iqdi99pd 742 22 eine eine FW cord-015365-iqdi99pd 742 23 bestimmte bestimmte JJ cord-015365-iqdi99pd 742 24 Höhe Höhe NNP cord-015365-iqdi99pd 742 25 überschreitet überschreitet JJ cord-015365-iqdi99pd 742 26 , , , cord-015365-iqdi99pd 742 27 aber aber NNP cord-015365-iqdi99pd 742 28 noch noch NNP cord-015365-iqdi99pd 742 29 bevor bevor NNP cord-015365-iqdi99pd 742 30 klinische klinische NNP cord-015365-iqdi99pd 742 31 Symptome Symptome NNP cord-015365-iqdi99pd 742 32 auftreten auftreten NNP cord-015365-iqdi99pd 742 33 . . . cord-015365-iqdi99pd 743 1 Die die VB cord-015365-iqdi99pd 743 2 Festsetzung Festsetzung NNP cord-015365-iqdi99pd 743 3 der der NNP cord-015365-iqdi99pd 744 1 virologischen virologischen NNP cord-015365-iqdi99pd 744 2 Grenzwerte Grenzwerte NNP cord-015365-iqdi99pd 745 1 fü fü IN cord-015365-iqdi99pd 746 1 r r LS cord-015365-iqdi99pd 746 2 den den NNP cord-015365-iqdi99pd 746 3 Einsatz Einsatz NNP cord-015365-iqdi99pd 746 4 der der NNP cord-015365-iqdi99pd 746 5 präemptive präemptive JJ cord-015365-iqdi99pd 747 1 Therapie Therapie NNP cord-015365-iqdi99pd 747 2 ist ist NNP cord-015365-iqdi99pd 748 1 aber aber NNP cord-015365-iqdi99pd 748 2 eine eine NNP cord-015365-iqdi99pd 748 3 große große NNP cord-015365-iqdi99pd 748 4 Herausforderung Herausforderung NNP cord-015365-iqdi99pd 748 5 , , , cord-015365-iqdi99pd 748 6 da da NNP cord-015365-iqdi99pd 748 7 vor vor NNP cord-015365-iqdi99pd 749 1 allem allem NNP cord-015365-iqdi99pd 749 2 Herpesviren Herpesviren NNP cord-015365-iqdi99pd 749 3 wie wie NNP cord-015365-iqdi99pd 749 4 Zytomegalievirus Zytomegalievirus NNP cord-015365-iqdi99pd 749 5 ( ( -LRB- cord-015365-iqdi99pd 749 6 CMV CMV NNP cord-015365-iqdi99pd 749 7 ) ) -RRB- cord-015365-iqdi99pd 750 1 oder oder NNP cord-015365-iqdi99pd 750 2 Epstein Epstein NNP cord-015365-iqdi99pd 750 3 - - HYPH cord-015365-iqdi99pd 750 4 Barr Barr NNP cord-015365-iqdi99pd 750 5 Virus Virus NNP cord-015365-iqdi99pd 750 6 ( ( -LRB- cord-015365-iqdi99pd 750 7 EBV EBV NNP cord-015365-iqdi99pd 750 8 ) ) -RRB- cord-015365-iqdi99pd 750 9 , , . cord-015365-iqdi99pd 751 1 aber aber NNP cord-015365-iqdi99pd 751 2 auch auch NNP cord-015365-iqdi99pd 751 3 Polyomaviren Polyomaviren NNP cord-015365-iqdi99pd 752 1 auch auch NNP cord-015365-iqdi99pd 752 2 ohne ohne NNP cord-015365-iqdi99pd 752 3 jede jede NNP cord-015365-iqdi99pd 752 4 Krankheitsrelevanz Krankheitsrelevanz NNP cord-015365-iqdi99pd 753 1 i -PRON- PRP cord-015365-iqdi99pd 753 2 m be VBP cord-015365-iqdi99pd 753 3 Organismus Organismus NNP cord-015365-iqdi99pd 753 4 nachgewiesen nachgewiesen NNP cord-015365-iqdi99pd 753 5 werden werden NNP cord-015365-iqdi99pd 753 6 können können NNP cord-015365-iqdi99pd 753 7 . . . cord-015365-iqdi99pd 754 1 Neben Neben NNP cord-015365-iqdi99pd 754 2 den den NNP cord-015365-iqdi99pd 754 3 quantitativen quantitativen NNP cord-015365-iqdi99pd 754 4 PCR PCR NNP cord-015365-iqdi99pd 754 5 Ergebnissen Ergebnissen NNP cord-015365-iqdi99pd 754 6 hängt hängt NNP cord-015365-iqdi99pd 754 7 der der NNP cord-015365-iqdi99pd 754 8 Einsatz Einsatz NNP cord-015365-iqdi99pd 754 9 einer einer NN cord-015365-iqdi99pd 754 10 präemptiven präemptiven NN cord-015365-iqdi99pd 754 11 Therapie Therapie NNP cord-015365-iqdi99pd 754 12 auch auch NNP cord-015365-iqdi99pd 754 13 von von NNP cord-015365-iqdi99pd 754 14 bestimmten bestimmten NNP cord-015365-iqdi99pd 754 15 weiteren weiteren NNP cord-015365-iqdi99pd 754 16 Aspekten Aspekten NNP cord-015365-iqdi99pd 754 17 ab ab NNP cord-015365-iqdi99pd 754 18 , , , cord-015365-iqdi99pd 754 19 wie wie NNP cord-015365-iqdi99pd 754 20 vom vom NNP cord-015365-iqdi99pd 755 1 Donor donor NN cord-015365-iqdi99pd 755 2 / / SYM cord-015365-iqdi99pd 755 3 Recipient Recipient NNP cord-015365-iqdi99pd 755 4 Virus Virus NNP cord-015365-iqdi99pd 755 5 - - HYPH cord-015365-iqdi99pd 755 6 serostatus serostatus NNP cord-015365-iqdi99pd 755 7 , , , cord-015365-iqdi99pd 755 8 dem dem NNP cord-015365-iqdi99pd 755 9 transplantierten transplantierten NNP cord-015365-iqdi99pd 755 10 Organ Organ NNP cord-015365-iqdi99pd 755 11 oder oder NNP cord-015365-iqdi99pd 755 12 vom vom NNP cord-015365-iqdi99pd 755 13 Material Material NNP cord-015365-iqdi99pd 755 14 in in IN cord-015365-iqdi99pd 755 15 dem dem JJ cord-015365-iqdi99pd 755 16 man man NN cord-015365-iqdi99pd 755 17 die die VB cord-015365-iqdi99pd 755 18 Virusnukleinsäure Virusnukleinsäure NNP cord-015365-iqdi99pd 755 19 nachweist nachweist NN cord-015365-iqdi99pd 755 20 . . . cord-015365-iqdi99pd 756 1 Daher Daher NNP cord-015365-iqdi99pd 756 2 ist ist NNP cord-015365-iqdi99pd 756 3 ein ein NN cord-015365-iqdi99pd 756 4 enges enge NNS cord-015365-iqdi99pd 756 5 Zusammenspiel Zusammenspiel NNP cord-015365-iqdi99pd 756 6 von von NNP cord-015365-iqdi99pd 756 7 virologischer virologischer NNP cord-015365-iqdi99pd 756 8 Befunderstellung Befunderstellung NNP cord-015365-iqdi99pd 756 9 , , , cord-015365-iqdi99pd 756 10 Interpretation Interpretation NNP cord-015365-iqdi99pd 756 11 und und IN cord-015365-iqdi99pd 757 1 der der NNP cord-015365-iqdi99pd 757 2 Kenntnis Kenntnis NNP cord-015365-iqdi99pd 757 3 der der NNP cord-015365-iqdi99pd 757 4 klinischen klinischen NNP cord-015365-iqdi99pd 757 5 Aspekte Aspekte NNP cord-015365-iqdi99pd 757 6 notwendig notwendig NNP cord-015365-iqdi99pd 757 7 , , , cord-015365-iqdi99pd 757 8 um um UH cord-015365-iqdi99pd 758 1 eine eine NNP cord-015365-iqdi99pd 758 2 optimale optimale NNP cord-015365-iqdi99pd 758 3 virologische virologische NNP cord-015365-iqdi99pd 758 4 Kontrolle Kontrolle NNP cord-015365-iqdi99pd 758 5 der der NNP cord-015365-iqdi99pd 758 6 einzelnen einzelnen NNP cord-015365-iqdi99pd 758 7 Patienten Patienten NNP cord-015365-iqdi99pd 758 8 zu zu NNP cord-015365-iqdi99pd 758 9 erreichen erreichen NNP cord-015365-iqdi99pd 758 10 . . . cord-015365-iqdi99pd 759 1 Antivirale Antivirale NNP cord-015365-iqdi99pd 759 2 Therapie Therapie NNP cord-015365-iqdi99pd 759 3 bei bei NNP cord-015365-iqdi99pd 759 4 Patienten Patienten NNP cord-015365-iqdi99pd 759 5 nach nach NNP cord-015365-iqdi99pd 759 6 Organ Organ NNP cord-015365-iqdi99pd 759 7 - - HYPH cord-015365-iqdi99pd 759 8 oder oder NNP cord-015365-iqdi99pd 759 9 hämatopoetischer hämatopoetischer NNP cord-015365-iqdi99pd 760 1 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 760 2 Klinische Klinische NNP cord-015365-iqdi99pd 760 3 Abteilung Abteilung NNP cord-015365-iqdi99pd 760 4 für für IN cord-015365-iqdi99pd 760 5 Pädiatrische Pädiatrische NNP cord-015365-iqdi99pd 760 6 Hämato-/Onkologie Hämato-/Onkologie NNP cord-015365-iqdi99pd 760 7 , , , cord-015365-iqdi99pd 761 1 Universitätsklinik Universitätsklinik NNP cord-015365-iqdi99pd 761 2 für für IN cord-015365-iqdi99pd 761 3 Kinder Kinder NNP cord-015365-iqdi99pd 761 4 - - HYPH cord-015365-iqdi99pd 761 5 und und NNP cord-015365-iqdi99pd 761 6 Jugendheilkunde Jugendheilkunde NNP cord-015365-iqdi99pd 761 7 , , , cord-015365-iqdi99pd 761 8 Medizinische Medizinische NNP cord-015365-iqdi99pd 761 9 Universität Universität NNP cord-015365-iqdi99pd 761 10 Graz Graz NNP cord-015365-iqdi99pd 761 11 , , , cord-015365-iqdi99pd 761 12 Graz Graz NNP cord-015365-iqdi99pd 761 13 , , , cord-015365-iqdi99pd 761 14 Österreich Österreich NNP cord-015365-iqdi99pd 761 15 Zahlreiche Zahlreiche NNP cord-015365-iqdi99pd 762 1 humanpathogene humanpathogene NNP cord-015365-iqdi99pd 762 2 Viren Viren NNP cord-015365-iqdi99pd 762 3 persistieren persistieren NNP cord-015365-iqdi99pd 762 4 nach nach NNP cord-015365-iqdi99pd 762 5 Primärinfektion Primärinfektion NNP cord-015365-iqdi99pd 763 1 i -PRON- PRP cord-015365-iqdi99pd 763 2 m be VBP cord-015365-iqdi99pd 763 3 Körper Körper NNP cord-015365-iqdi99pd 763 4 und und IN cord-015365-iqdi99pd 763 5 können können XX cord-015365-iqdi99pd 764 1 unter unter NNP cord-015365-iqdi99pd 764 2 geschwächter geschwächter NNP cord-015365-iqdi99pd 765 1 Abwehrlage Abwehrlage NNP cord-015365-iqdi99pd 765 2 reaktiviert reaktiviert NN cord-015365-iqdi99pd 765 3 werden werden NNP cord-015365-iqdi99pd 765 4 . . . cord-015365-iqdi99pd 766 1 Zu Zu NNP cord-015365-iqdi99pd 766 2 diesen diesen NNP cord-015365-iqdi99pd 766 3 zählen zählen MD cord-015365-iqdi99pd 766 4 die die VBP cord-015365-iqdi99pd 766 5 Herpesviren Herpesviren NNP cord-015365-iqdi99pd 766 6 Herpes Herpes NNP cord-015365-iqdi99pd 767 1 simples simple NNS cord-015365-iqdi99pd 767 2 1 1 CD cord-015365-iqdi99pd 767 3 und und RB cord-015365-iqdi99pd 767 4 2 2 CD cord-015365-iqdi99pd 768 1 ( ( -LRB- cord-015365-iqdi99pd 768 2 HSV HSV NNP cord-015365-iqdi99pd 768 3 1 1 CD cord-015365-iqdi99pd 768 4 , , , cord-015365-iqdi99pd 768 5 2 2 CD cord-015365-iqdi99pd 768 6 ) ) -RRB- cord-015365-iqdi99pd 768 7 , , , cord-015365-iqdi99pd 768 8 Cytomegalievirus Cytomegalievirus NNP cord-015365-iqdi99pd 768 9 ( ( -LRB- cord-015365-iqdi99pd 768 10 CMV CMV NNP cord-015365-iqdi99pd 768 11 ) ) -RRB- cord-015365-iqdi99pd 768 12 , , , cord-015365-iqdi99pd 768 13 Epstein Epstein NNP cord-015365-iqdi99pd 768 14 - - HYPH cord-015365-iqdi99pd 768 15 Barr Barr NNP cord-015365-iqdi99pd 768 16 - - HYPH cord-015365-iqdi99pd 768 17 Virus Virus NNP cord-015365-iqdi99pd 768 18 ( ( -LRB- cord-015365-iqdi99pd 768 19 EBV EBV NNP cord-015365-iqdi99pd 768 20 ) ) -RRB- cord-015365-iqdi99pd 768 21 , , . cord-015365-iqdi99pd 769 1 Varicella Varicella NNP cord-015365-iqdi99pd 769 2 Zoster Zoster NNP cord-015365-iqdi99pd 769 3 Virus virus NN cord-015365-iqdi99pd 769 4 ( ( -LRB- cord-015365-iqdi99pd 769 5 VZV VZV NNP cord-015365-iqdi99pd 769 6 ) ) -RRB- cord-015365-iqdi99pd 769 7 und und RB cord-015365-iqdi99pd 770 1 HHV-6 HHV-6 NNP cord-015365-iqdi99pd 770 2 sowie sowie CD cord-015365-iqdi99pd 770 3 das das NNP cord-015365-iqdi99pd 770 4 Parvovirus Parvovirus NNP cord-015365-iqdi99pd 770 5 B B NNP cord-015365-iqdi99pd 770 6 19 19 CD cord-015365-iqdi99pd 770 7 ( ( -LRB- cord-015365-iqdi99pd 770 8 PVB19 PVB19 NNP cord-015365-iqdi99pd 770 9 ) ) -RRB- cord-015365-iqdi99pd 770 10 , , , cord-015365-iqdi99pd 770 11 das das NNP cord-015365-iqdi99pd 770 12 Adenovirus Adenovirus NNP cord-015365-iqdi99pd 770 13 ( ( -LRB- cord-015365-iqdi99pd 770 14 ADV ADV NNP cord-015365-iqdi99pd 770 15 ) ) -RRB- cord-015365-iqdi99pd 770 16 , , , cord-015365-iqdi99pd 770 17 die die VBP cord-015365-iqdi99pd 770 18 Hepatitisviren Hepatitisviren NNP cord-015365-iqdi99pd 770 19 B B NNP cord-015365-iqdi99pd 770 20 ( ( -LRB- cord-015365-iqdi99pd 770 21 HBV HBV NNP cord-015365-iqdi99pd 770 22 ) ) -RRB- cord-015365-iqdi99pd 771 1 und und NNP cord-015365-iqdi99pd 772 1 C C NNP cord-015365-iqdi99pd 772 2 ( ( -LRB- cord-015365-iqdi99pd 772 3 HCV HCV NNP cord-015365-iqdi99pd 772 4 ) ) -RRB- cord-015365-iqdi99pd 773 1 und und NNP cord-015365-iqdi99pd 774 1 die die VB cord-015365-iqdi99pd 775 1 Polyomaviren Polyomaviren NNP cord-015365-iqdi99pd 775 2 BK BK NNP cord-015365-iqdi99pd 775 3 - - HYPH cord-015365-iqdi99pd 775 4 Virus Virus NNP cord-015365-iqdi99pd 776 1 ( ( -LRB- cord-015365-iqdi99pd 776 2 BKV BKV NNP cord-015365-iqdi99pd 776 3 ) ) -RRB- cord-015365-iqdi99pd 776 4 und und IN cord-015365-iqdi99pd 776 5 JC JC NNP cord-015365-iqdi99pd 776 6 - - HYPH cord-015365-iqdi99pd 776 7 Virus Virus NNP cord-015365-iqdi99pd 776 8 ( ( -LRB- cord-015365-iqdi99pd 776 9 JCV JCV NNP cord-015365-iqdi99pd 776 10 ) ) -RRB- cord-015365-iqdi99pd 776 11 . . . cord-015365-iqdi99pd 777 1 Diese Diese NNP cord-015365-iqdi99pd 777 2 und und IN cord-015365-iqdi99pd 777 3 andere andere FW cord-015365-iqdi99pd 777 4 Viren Viren NNP cord-015365-iqdi99pd 777 5 ( ( -LRB- cord-015365-iqdi99pd 777 6 z. z. NNP cord-015365-iqdi99pd 777 7 B. B. NNP cord-015365-iqdi99pd 777 8 Enteroviren Enteroviren NNP cord-015365-iqdi99pd 777 9 ) ) -RRB- cord-015365-iqdi99pd 778 1 können können UH cord-015365-iqdi99pd 778 2 bei bei NNP cord-015365-iqdi99pd 778 3 Empfängern Empfängern NNP cord-015365-iqdi99pd 778 4 von von VBP cord-015365-iqdi99pd 778 5 Organoder Organoder NNP cord-015365-iqdi99pd 778 6 Stammzelltransplantationen Stammzelltransplantationen NNP cord-015365-iqdi99pd 779 1 durch durch NNP cord-015365-iqdi99pd 779 2 Primärinfektion Primärinfektion NNP cord-015365-iqdi99pd 779 3 oder oder NN cord-015365-iqdi99pd 779 4 Reaktivierung Reaktivierung NNP cord-015365-iqdi99pd 779 5 zu zu NNP cord-015365-iqdi99pd 779 6 schweren schweren NNP cord-015365-iqdi99pd 779 7 Krankheitsverläufen Krankheitsverläufen NNP cord-015365-iqdi99pd 779 8 ( ( -LRB- cord-015365-iqdi99pd 779 9 " " `` cord-015365-iqdi99pd 779 10 Virus virus NN cord-015365-iqdi99pd 779 11 - - HYPH cord-015365-iqdi99pd 779 12 Sepsis Sepsis NNP cord-015365-iqdi99pd 779 13 " " '' cord-015365-iqdi99pd 779 14 ) ) -RRB- cord-015365-iqdi99pd 780 1 und und NNP cord-015365-iqdi99pd 781 1 immunologischen immunologischen NNP cord-015365-iqdi99pd 781 2 Prozessen Prozessen NNP cord-015365-iqdi99pd 781 3 wie wie NNP cord-015365-iqdi99pd 781 4 Transplantatabstoßung Transplantatabstoßung NNP cord-015365-iqdi99pd 781 5 oder oder NN cord-015365-iqdi99pd 781 6 Graft graft NN cord-015365-iqdi99pd 781 7 - - HYPH cord-015365-iqdi99pd 781 8 versus versus IN cord-015365-iqdi99pd 781 9 - - HYPH cord-015365-iqdi99pd 781 10 Host host NN cord-015365-iqdi99pd 781 11 Disease Disease NNP cord-015365-iqdi99pd 781 12 führen führen NNP cord-015365-iqdi99pd 781 13 . . . cord-015365-iqdi99pd 782 1 Neben Neben NNP cord-015365-iqdi99pd 782 2 unspezifischen unspezifischen NNP cord-015365-iqdi99pd 782 3 Maßnahmen Maßnahmen NNP cord-015365-iqdi99pd 782 4 wie wie NNP cord-015365-iqdi99pd 782 5 Reduktion Reduktion NNP cord-015365-iqdi99pd 782 6 der der NNP cord-015365-iqdi99pd 782 7 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 782 8 , , , cord-015365-iqdi99pd 782 9 Gabe Gabe NNP cord-015365-iqdi99pd 782 10 von von NNP cord-015365-iqdi99pd 782 11 Immunglobulinen Immunglobulinen NNP cord-015365-iqdi99pd 782 12 und und IN cord-015365-iqdi99pd 782 13 Immunmodulation Immunmodulation NNP cord-015365-iqdi99pd 782 14 mittels mittels NNP cord-015365-iqdi99pd 783 1 Interferon interferon NN cord-015365-iqdi99pd 783 2 , , , cord-015365-iqdi99pd 783 3 wurde wurde NNP cord-015365-iqdi99pd 783 4 in in IN cord-015365-iqdi99pd 783 5 den den NNP cord-015365-iqdi99pd 783 6 letzten letzten NNP cord-015365-iqdi99pd 783 7 Jahren Jahren NNP cord-015365-iqdi99pd 783 8 eine eine NNP cord-015365-iqdi99pd 783 9 zunehmende zunehmende NNP cord-015365-iqdi99pd 783 10 Zahl Zahl NNP cord-015365-iqdi99pd 783 11 antiviraler antiviraler NN cord-015365-iqdi99pd 783 12 Substanzen Substanzen NNP cord-015365-iqdi99pd 783 13 verfügbar verfügbar NN cord-015365-iqdi99pd 783 14 . . . cord-015365-iqdi99pd 784 1 Deren Deren NNP cord-015365-iqdi99pd 784 2 antiviraler antiviraler NN cord-015365-iqdi99pd 784 3 Effekt Effekt NNP cord-015365-iqdi99pd 784 4 beruht beruht NNP cord-015365-iqdi99pd 784 5 auf auf NNP cord-015365-iqdi99pd 784 6 unterschiedlichen unterschiedlichen NNP cord-015365-iqdi99pd 784 7 Mechanismen Mechanismen NNP cord-015365-iqdi99pd 784 8 : : : cord-015365-iqdi99pd 785 1 Hemmung Hemmung NNP cord-015365-iqdi99pd 785 2 der der NNP cord-015365-iqdi99pd 785 3 Aufnahme Aufnahme NNP cord-015365-iqdi99pd 785 4 der der NNP cord-015365-iqdi99pd 785 5 Viren Viren NNP cord-015365-iqdi99pd 785 6 in in IN cord-015365-iqdi99pd 785 7 die die JJ cord-015365-iqdi99pd 785 8 Wirtszelle Wirtszelle NNP cord-015365-iqdi99pd 785 9 ( ( -LRB- cord-015365-iqdi99pd 785 10 Amantadin Amantadin NNP cord-015365-iqdi99pd 785 11 , , , cord-015365-iqdi99pd 785 12 Pleconaril Pleconaril NNP cord-015365-iqdi99pd 785 13 ) ) -RRB- cord-015365-iqdi99pd 785 14 , , , cord-015365-iqdi99pd 785 15 Inhibierung Inhibierung NNP cord-015365-iqdi99pd 785 16 der der NNP cord-015365-iqdi99pd 785 17 Replikation Replikation NNP cord-015365-iqdi99pd 785 18 des des NN cord-015365-iqdi99pd 786 1 viralen viralen NNP cord-015365-iqdi99pd 786 2 Genoms Genoms NNP cord-015365-iqdi99pd 786 3 ( ( -LRB- cord-015365-iqdi99pd 786 4 Aciclovir Aciclovir NNP cord-015365-iqdi99pd 786 5 , , , cord-015365-iqdi99pd 786 6 Ganciclovir Ganciclovir NNP cord-015365-iqdi99pd 786 7 , , , cord-015365-iqdi99pd 786 8 Cidofovir Cidofovir NNP cord-015365-iqdi99pd 786 9 , , , cord-015365-iqdi99pd 786 10 Foscarnet Foscarnet NNP cord-015365-iqdi99pd 786 11 , , , cord-015365-iqdi99pd 786 12 Ribavirin Ribavirin NNP cord-015365-iqdi99pd 786 13 ) ) -RRB- cord-015365-iqdi99pd 786 14 , , , cord-015365-iqdi99pd 786 15 Unterdrückung Unterdrückung NNP cord-015365-iqdi99pd 786 16 der der NNP cord-015365-iqdi99pd 786 17 Freisetzung Freisetzung NNP cord-015365-iqdi99pd 786 18 von von NNP cord-015365-iqdi99pd 786 19 Viruspartikeln Viruspartikeln NNP cord-015365-iqdi99pd 786 20 aus aus NNP cord-015365-iqdi99pd 786 21 der der NNP cord-015365-iqdi99pd 786 22 Wirtszelle Wirtszelle NNP cord-015365-iqdi99pd 786 23 ( ( -LRB- cord-015365-iqdi99pd 786 24 Oseltamivir Oseltamivir NNP cord-015365-iqdi99pd 786 25 , , , cord-015365-iqdi99pd 786 26 Zanamivir Zanamivir NNP cord-015365-iqdi99pd 786 27 ) ) -RRB- cord-015365-iqdi99pd 786 28 . . . cord-015365-iqdi99pd 787 1 All all DT cord-015365-iqdi99pd 787 2 diese diese NNP cord-015365-iqdi99pd 787 3 Substanzen Substanzen NNP cord-015365-iqdi99pd 787 4 wirken wirken NNP cord-015365-iqdi99pd 787 5 virustatisch virustatisch NNP cord-015365-iqdi99pd 787 6 und und NNP cord-015365-iqdi99pd 787 7 nicht nicht NNP cord-015365-iqdi99pd 787 8 viruzid viruzid NNP cord-015365-iqdi99pd 787 9 , , , cord-015365-iqdi99pd 787 10 können können NNP cord-015365-iqdi99pd 787 11 also also RB cord-015365-iqdi99pd 787 12 die die VBP cord-015365-iqdi99pd 787 13 Virusvermehrung Virusvermehrung NNP cord-015365-iqdi99pd 787 14 hemmen hemmen NN cord-015365-iqdi99pd 787 15 , , . cord-015365-iqdi99pd 788 1 nicht nicht NNP cord-015365-iqdi99pd 788 2 jedoch jedoch NNP cord-015365-iqdi99pd 788 3 die die VBP cord-015365-iqdi99pd 788 4 Viren Viren NNP cord-015365-iqdi99pd 788 5 gänzlich gänzlich NNP cord-015365-iqdi99pd 788 6 eliminieren eliminieren NNP cord-015365-iqdi99pd 788 7 . . . cord-015365-iqdi99pd 789 1 Während Während NNP cord-015365-iqdi99pd 789 2 einige einige NNP cord-015365-iqdi99pd 789 3 Substanzen Substanzen NNP cord-015365-iqdi99pd 789 4 relativ relativ JJ cord-015365-iqdi99pd 789 5 spezifisch spezifisch NN cord-015365-iqdi99pd 789 6 in in IN cord-015365-iqdi99pd 789 7 die die NN cord-015365-iqdi99pd 790 1 Replikationsmechanismen Replikationsmechanismen NNP cord-015365-iqdi99pd 790 2 einzelner einzelner NN cord-015365-iqdi99pd 790 3 Viren Viren NNP cord-015365-iqdi99pd 790 4 eingreifen eingreifen NNP cord-015365-iqdi99pd 790 5 ( ( -LRB- cord-015365-iqdi99pd 790 6 Aciclovir Aciclovir NNP cord-015365-iqdi99pd 790 7 , , , cord-015365-iqdi99pd 790 8 Ribavirin Ribavirin NNP cord-015365-iqdi99pd 790 9 , , , cord-015365-iqdi99pd 790 10 Oseltamivir Oseltamivir NNP cord-015365-iqdi99pd 790 11 , , , cord-015365-iqdi99pd 790 12 Zanamivir Zanamivir NNP cord-015365-iqdi99pd 790 13 ) ) -RRB- cord-015365-iqdi99pd 790 14 , , , cord-015365-iqdi99pd 791 1 zeigen zeigen NNP cord-015365-iqdi99pd 791 2 andere andere NNP cord-015365-iqdi99pd 791 3 Substanzenmeist Substanzenmeist NNP cord-015365-iqdi99pd 791 4 jene jene NNP cord-015365-iqdi99pd 791 5 mit mit NNP cord-015365-iqdi99pd 791 6 breiterem breiterem NNP cord-015365-iqdi99pd 791 7 Wirkspektrum Wirkspektrum NNP cord-015365-iqdi99pd 791 8 ( ( -LRB- cord-015365-iqdi99pd 791 9 Cidofovir Cidofovir NNP cord-015365-iqdi99pd 791 10 , , , cord-015365-iqdi99pd 791 11 Foscarnet Foscarnet NNP cord-015365-iqdi99pd 791 12 ) ) -RRB- cord-015365-iqdi99pd 792 1 -auch -auch JJ cord-015365-iqdi99pd 792 2 eine eine NNP cord-015365-iqdi99pd 792 3 vermehrte vermehrte NNP cord-015365-iqdi99pd 792 4 Aktivität Aktivität NNP cord-015365-iqdi99pd 792 5 innerhalb innerhalb NNP cord-015365-iqdi99pd 792 6 humaner humaner NN cord-015365-iqdi99pd 792 7 , , , cord-015365-iqdi99pd 792 8 molekularer molekularer NNP cord-015365-iqdi99pd 792 9 Mechanismen Mechanismen NNP cord-015365-iqdi99pd 792 10 , , , cord-015365-iqdi99pd 792 11 was be VBD cord-015365-iqdi99pd 792 12 zu zu NNP cord-015365-iqdi99pd 793 1 einer einer NNP cord-015365-iqdi99pd 793 2 beträchtlichen beträchtlichen NNP cord-015365-iqdi99pd 793 3 Zahl Zahl NNP cord-015365-iqdi99pd 794 1 unerwü unerwü NNP cord-015365-iqdi99pd 794 2 nschter nschter NNP cord-015365-iqdi99pd 795 1 Arzneimittelwirkungen Arzneimittelwirkungen NNP cord-015365-iqdi99pd 795 2 fü fü IN cord-015365-iqdi99pd 795 3 hrt hrt NNP cord-015365-iqdi99pd 795 4 ( ( -LRB- cord-015365-iqdi99pd 795 5 v. v. CC cord-015365-iqdi99pd 795 6 a. a. NN cord-015365-iqdi99pd 796 1 Nephro- Nephro- NNP cord-015365-iqdi99pd 796 2 , , , cord-015365-iqdi99pd 796 3 Myelo- Myelo- NNP cord-015365-iqdi99pd 796 4 , , , cord-015365-iqdi99pd 796 5 Neurotoxizität Neurotoxizität NNP cord-015365-iqdi99pd 796 6 ) ) -RRB- cord-015365-iqdi99pd 796 7 . . . cord-015365-iqdi99pd 797 1 Handelsname Handelsname NNP cord-015365-iqdi99pd 797 2 DNA DNA NNP cord-015365-iqdi99pd 797 3 - - HYPH cord-015365-iqdi99pd 797 4 Viren Viren NNP cord-015365-iqdi99pd 797 5 RNA RNA NNP cord-015365-iqdi99pd 797 6 - - HYPH cord-015365-iqdi99pd 797 7 Viren Viren NNP cord-015365-iqdi99pd 798 1 Ciprofloxacin Ciprofloxacin NNP cord-015365-iqdi99pd 799 1 * * NFP cord-015365-iqdi99pd 799 2 * * NFP cord-015365-iqdi99pd 799 3 Ciproxin Ciproxin NNP cord-015365-iqdi99pd 799 4 þ þ NNP cord-015365-iqdi99pd 799 5 ( ( -LRB- cord-015365-iqdi99pd 799 6 in in IN cord-015365-iqdi99pd 799 7 vitro vitro FW cord-015365-iqdi99pd 799 8 ) ) -RRB- cord-015365-iqdi99pd 800 1 Wirkspektrum Wirkspektrum NNP cord-015365-iqdi99pd 800 2 ausgewählter ausgewählter NN cord-015365-iqdi99pd 800 3 Virustatika Virustatika NNP cord-015365-iqdi99pd 801 1 ( ( -LRB- cord-015365-iqdi99pd 801 2 ohne ohne NNP cord-015365-iqdi99pd 801 3 anti anti NNP cord-015365-iqdi99pd 801 4 - - NNP cord-015365-iqdi99pd 801 5 retrovirale retrovirale JJ cord-015365-iqdi99pd 801 6 Substanzen Substanzen NNP cord-015365-iqdi99pd 801 7 ) ) -RRB- cord-015365-iqdi99pd 802 1 Wirksamkeit Wirksamkeit NNP cord-015365-iqdi99pd 802 2 entspricht entspricht NNP cord-015365-iqdi99pd 803 1 nicht nicht NNP cord-015365-iqdi99pd 803 2 den den NNP cord-015365-iqdi99pd 803 3 zugelassenen zugelassenen NNP cord-015365-iqdi99pd 803 4 Indikationen Indikationen NNP cord-015365-iqdi99pd 804 1 * * NFP cord-015365-iqdi99pd 804 2 experimentell experimentell NNP cord-015365-iqdi99pd 804 3 , , , cord-015365-iqdi99pd 804 4 nicht nicht NNP cord-015365-iqdi99pd 804 5 verfügbar verfügbar NNP cord-015365-iqdi99pd 805 1 * * NFP cord-015365-iqdi99pd 805 2 * * NFP cord-015365-iqdi99pd 805 3 experimentell experimentell NNP cord-015365-iqdi99pd 806 1 Einige Einige NNP cord-015365-iqdi99pd 806 2 Substanzen Substanzen NNP cord-015365-iqdi99pd 806 3 haben haben NNP cord-015365-iqdi99pd 807 1 i -PRON- PRP cord-015365-iqdi99pd 807 2 m be VBP cord-015365-iqdi99pd 807 3 Tierversuch Tierversuch NNP cord-015365-iqdi99pd 807 4 ein ein NNP cord-015365-iqdi99pd 807 5 carcinogenes carcinogene NNS cord-015365-iqdi99pd 807 6 ( ( -LRB- cord-015365-iqdi99pd 807 7 Ganciclovir Ganciclovir NNP cord-015365-iqdi99pd 807 8 , , , cord-015365-iqdi99pd 807 9 Cidofovir Cidofovir NNP cord-015365-iqdi99pd 807 10 ) ) -RRB- cord-015365-iqdi99pd 807 11 und und NNP cord-015365-iqdi99pd 807 12 / / SYM cord-015365-iqdi99pd 807 13 oder oder NNP cord-015365-iqdi99pd 807 14 teratogenes teratogenes NNPS cord-015365-iqdi99pd 807 15 ( ( -LRB- cord-015365-iqdi99pd 807 16 Ganciclovir Ganciclovir NNP cord-015365-iqdi99pd 807 17 , , , cord-015365-iqdi99pd 807 18 Cidofovir Cidofovir NNP cord-015365-iqdi99pd 807 19 , , , cord-015365-iqdi99pd 807 20 Ribavirin Ribavirin NNP cord-015365-iqdi99pd 807 21 ) ) -RRB- cord-015365-iqdi99pd 808 1 Potenzial Potenzial NNP cord-015365-iqdi99pd 808 2 gezeigt gezeigt VBZ cord-015365-iqdi99pd 808 3 . . . cord-015365-iqdi99pd 809 1 Unter Unter NNP cord-015365-iqdi99pd 809 2 zu zu XX cord-015365-iqdi99pd 810 1 geringer geringer NNP cord-015365-iqdi99pd 810 2 Dosierung Dosierung NNP cord-015365-iqdi99pd 811 1 und und NNP cord-015365-iqdi99pd 812 1 /oder /oder NNP cord-015365-iqdi99pd 812 2 mangelhafter mangelhafter NNP cord-015365-iqdi99pd 812 3 Medikamenteneinnahme Medikamenteneinnahme NNP cord-015365-iqdi99pd 812 4 kann kann NNP cord-015365-iqdi99pd 812 5 es es XX cord-015365-iqdi99pd 812 6 zu zu NNP cord-015365-iqdi99pd 813 1 viralen viralen NNP cord-015365-iqdi99pd 813 2 Mutationen Mutationen NNP cord-015365-iqdi99pd 814 1 und und NNP cord-015365-iqdi99pd 815 1 -daraus -daraus : cord-015365-iqdi99pd 815 2 resultierend resultierend VB cord-015365-iqdi99pd 816 1 -zur -zur . cord-015365-iqdi99pd 817 1 Resistenzentwicklung Resistenzentwicklung NNP cord-015365-iqdi99pd 817 2 kommen kommen NNP cord-015365-iqdi99pd 817 3 . . . cord-015365-iqdi99pd 818 1 Tabelle Tabelle NNP cord-015365-iqdi99pd 818 2 1 1 CD cord-015365-iqdi99pd 818 3 gibt gibt NNP cord-015365-iqdi99pd 818 4 einen einen NNP cord-015365-iqdi99pd 818 5 Ü Ü NNP cord-015365-iqdi99pd 818 6 berblick berblick NNP cord-015365-iqdi99pd 819 1 über über NNP cord-015365-iqdi99pd 819 2 die die VBP cord-015365-iqdi99pd 820 1 wichtigsten wichtigsten NNP cord-015365-iqdi99pd 820 2 Virustatika Virustatika NNP cord-015365-iqdi99pd 820 3 und und IN cord-015365-iqdi99pd 820 4 deren deren NNP cord-015365-iqdi99pd 820 5 Wirkspektrum Wirkspektrum NNP cord-015365-iqdi99pd 820 6 . . . cord-015365-iqdi99pd 821 1 Viele Viele NNP cord-015365-iqdi99pd 821 2 dieser dieser NNP cord-015365-iqdi99pd 822 1 Substanzen substanzen NN cord-015365-iqdi99pd 822 2 sind sind NN cord-015365-iqdi99pd 823 1 jedoch jedoch NNP cord-015365-iqdi99pd 823 2 für für NNP cord-015365-iqdi99pd 823 3 die die VBP cord-015365-iqdi99pd 823 4 Anwendung Anwendung NNP cord-015365-iqdi99pd 823 5 i i PRP cord-015365-iqdi99pd 824 1 m m LS cord-015365-iqdi99pd 824 2 " " `` cord-015365-iqdi99pd 824 3 Transplantations Transplantations NNP cord-015365-iqdi99pd 824 4 - - HYPH cord-015365-iqdi99pd 824 5 Setting set VBG cord-015365-iqdi99pd 824 6 " " `` cord-015365-iqdi99pd 824 7 nicht nicht NNP cord-015365-iqdi99pd 824 8 offiziell offiziell NNP cord-015365-iqdi99pd 824 9 zugelassen zugelassen NNP cord-015365-iqdi99pd 824 10 . . . cord-015365-iqdi99pd 825 1 In in IN cord-015365-iqdi99pd 825 2 Zukunft Zukunft NNP cord-015365-iqdi99pd 825 3 sind sind NNP cord-015365-iqdi99pd 825 4 weitere weitere NNP cord-015365-iqdi99pd 825 5 , , , cord-015365-iqdi99pd 825 6 teilweise teilweise RB cord-015365-iqdi99pd 825 7 dzt dzt NN cord-015365-iqdi99pd 825 8 . . . cord-015365-iqdi99pd 826 1 noch noch NNP cord-015365-iqdi99pd 826 2 experimentell experimentell NNP cord-015365-iqdi99pd 827 1 eingesetzte eingesetzte NNP cord-015365-iqdi99pd 828 1 Therapieoptionen Therapieoptionen NNP cord-015365-iqdi99pd 828 2 zu zu NNP cord-015365-iqdi99pd 828 3 erwarten erwarten NNP cord-015365-iqdi99pd 828 4 : : : cord-015365-iqdi99pd 829 1 so so RB cord-015365-iqdi99pd 829 2 scheint scheint NNP cord-015365-iqdi99pd 829 3 Ciprofloxacin Ciprofloxacin NNP cord-015365-iqdi99pd 829 4 als als NNP cord-015365-iqdi99pd 829 5 Gyrasehemmer Gyrasehemmer NNP cord-015365-iqdi99pd 829 6 auch auch NNP cord-015365-iqdi99pd 829 7 gegen gegen NNP cord-015365-iqdi99pd 829 8 Polyomaviren Polyomaviren NNP cord-015365-iqdi99pd 829 9 wirksam wirksam NNP cord-015365-iqdi99pd 829 10 zu zu NNP cord-015365-iqdi99pd 829 11 sein sein NNP cord-015365-iqdi99pd 829 12 , , , cord-015365-iqdi99pd 829 13 mit mit NNP cord-015365-iqdi99pd 829 14 CMX001 CMX001 NNP cord-015365-iqdi99pd 829 15 wird wird NNP cord-015365-iqdi99pd 830 1 eine eine NNP cord-015365-iqdi99pd 830 2 wirksamere wirksamere NNP cord-015365-iqdi99pd 831 1 und und NNP cord-015365-iqdi99pd 831 2 nebenwirkungsärmere nebenwirkungsärmere RB cord-015365-iqdi99pd 832 1 Weiterentwicklung Weiterentwicklung NNP cord-015365-iqdi99pd 832 2 von von NNP cord-015365-iqdi99pd 832 3 Cidofovir Cidofovir NNP cord-015365-iqdi99pd 832 4 derzeit derzeit NNP cord-015365-iqdi99pd 832 5 klinischen klinischen NNP cord-015365-iqdi99pd 832 6 Tests Tests NNPS cord-015365-iqdi99pd 832 7 unterzogen unterzogen NNP cord-015365-iqdi99pd 832 8 . . . cord-015365-iqdi99pd 833 1 Reaktivierungen Reaktivierungen NNP cord-015365-iqdi99pd 833 2 von von NNP cord-015365-iqdi99pd 833 3 persistierenden persistierenden NNP cord-015365-iqdi99pd 834 1 Virusinfektionen Virusinfektionen NNP cord-015365-iqdi99pd 834 2 sind sind NNP cord-015365-iqdi99pd 834 3 häufige häufige NNP cord-015365-iqdi99pd 834 4 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 834 5 nach nach NNP cord-015365-iqdi99pd 834 6 Transplantation Transplantation NNP cord-015365-iqdi99pd 834 7 . . . cord-015365-iqdi99pd 835 1 Je Je NNP cord-015365-iqdi99pd 835 2 nach nach NNP cord-015365-iqdi99pd 835 3 Risikokonstellation Risikokonstellation NNP cord-015365-iqdi99pd 835 4 reicht reicht NNP cord-015365-iqdi99pd 835 5 das das NNP cord-015365-iqdi99pd 835 6 klinische klinische NNP cord-015365-iqdi99pd 835 7 Spektrum Spektrum NNP cord-015365-iqdi99pd 835 8 von von NNP cord-015365-iqdi99pd 835 9 einem einem NNP cord-015365-iqdi99pd 835 10 harmlosen harmlosen NNP cord-015365-iqdi99pd 836 1 Infekt infekt NN cord-015365-iqdi99pd 836 2 bis bis NN cord-015365-iqdi99pd 836 3 zu zu XX cord-015365-iqdi99pd 837 1 einem einem NNP cord-015365-iqdi99pd 837 2 lebensbedrohlichen lebensbedrohlichen NNP cord-015365-iqdi99pd 837 3 Infektionsverlauf Infektionsverlauf NNP cord-015365-iqdi99pd 837 4 . . . cord-015365-iqdi99pd 838 1 Die die VB cord-015365-iqdi99pd 838 2 häufigsten häufigsten NNP cord-015365-iqdi99pd 839 1 Pathogene Pathogene NNP cord-015365-iqdi99pd 839 2 sind sind NNP cord-015365-iqdi99pd 839 3 Cytomegalievirus Cytomegalievirus NNP cord-015365-iqdi99pd 839 4 ( ( -LRB- cord-015365-iqdi99pd 839 5 CMV CMV NNP cord-015365-iqdi99pd 839 6 ) ) -RRB- cord-015365-iqdi99pd 839 7 , , , cord-015365-iqdi99pd 839 8 Epstein Epstein NNP cord-015365-iqdi99pd 839 9 - - HYPH cord-015365-iqdi99pd 839 10 Barr Barr NNP cord-015365-iqdi99pd 839 11 Virus Virus NNP cord-015365-iqdi99pd 839 12 ( ( -LRB- cord-015365-iqdi99pd 839 13 EBV EBV NNP cord-015365-iqdi99pd 839 14 ) ) -RRB- cord-015365-iqdi99pd 840 1 und und NNP cord-015365-iqdi99pd 841 1 Adenoviren Adenoviren NNP cord-015365-iqdi99pd 841 2 ( ( -LRB- cord-015365-iqdi99pd 841 3 ADV ADV NNP cord-015365-iqdi99pd 841 4 ) ) -RRB- cord-015365-iqdi99pd 841 5 . . . cord-015365-iqdi99pd 842 1 Die die VB cord-015365-iqdi99pd 843 1 Möglichkeiten Möglichkeiten NNP cord-015365-iqdi99pd 843 2 der der NNP cord-015365-iqdi99pd 843 3 virostatischen virostatischen NNP cord-015365-iqdi99pd 844 1 Pharmakotherapie Pharmakotherapie NNP cord-015365-iqdi99pd 844 2 sind sind NNP cord-015365-iqdi99pd 844 3 meist meist NNP cord-015365-iqdi99pd 844 4 limitiert limitiert NNP cord-015365-iqdi99pd 844 5 . . . cord-015365-iqdi99pd 845 1 Alle Alle NNP cord-015365-iqdi99pd 845 2 drei drei NNP cord-015365-iqdi99pd 845 3 Virusinfektionen Virusinfektionen NNP cord-015365-iqdi99pd 845 4 haben haben NNP cord-015365-iqdi99pd 845 5 gemeinsam gemeinsam NNP cord-015365-iqdi99pd 845 6 , , , cord-015365-iqdi99pd 845 7 dass dass NNP cord-015365-iqdi99pd 845 8 fü fü IN cord-015365-iqdi99pd 845 9 r r NNP cord-015365-iqdi99pd 845 10 eine eine NNP cord-015365-iqdi99pd 845 11 Elimination Elimination NNP cord-015365-iqdi99pd 845 12 eine eine NNP cord-015365-iqdi99pd 845 13 suffiziente suffiziente NNP cord-015365-iqdi99pd 845 14 T T NNP cord-015365-iqdi99pd 845 15 - - HYPH cord-015365-iqdi99pd 845 16 Zellimmunität Zellimmunität NNP cord-015365-iqdi99pd 845 17 notwendig notwendig JJ cord-015365-iqdi99pd 845 18 ist ist NN cord-015365-iqdi99pd 845 19 . . . cord-015365-iqdi99pd 846 1 Darauf Darauf NNP cord-015365-iqdi99pd 846 2 baut baut NNP cord-015365-iqdi99pd 846 3 die die VB cord-015365-iqdi99pd 846 4 Rationale rationale NN cord-015365-iqdi99pd 846 5 eines eine NNS cord-015365-iqdi99pd 846 6 adoptiven adoptiven NN cord-015365-iqdi99pd 846 7 Immuntransfers Immuntransfers NNP cord-015365-iqdi99pd 846 8 auf auf NNP cord-015365-iqdi99pd 846 9 , , , cord-015365-iqdi99pd 847 1 bei bei NNP cord-015365-iqdi99pd 847 2 dem dem NNP cord-015365-iqdi99pd 847 3 Ag Ag NNP cord-015365-iqdi99pd 847 4 - - HYPH cord-015365-iqdi99pd 847 5 spezifische spezifische NNP cord-015365-iqdi99pd 847 6 T T NNP cord-015365-iqdi99pd 847 7 - - HYPH cord-015365-iqdi99pd 847 8 Zellen Zellen NNP cord-015365-iqdi99pd 847 9 von von NNP cord-015365-iqdi99pd 847 10 einem einem NNP cord-015365-iqdi99pd 847 11 gesunden gesunden NNP cord-015365-iqdi99pd 847 12 Spender Spender NNP cord-015365-iqdi99pd 847 13 in in IN cord-015365-iqdi99pd 847 14 einen einen JJ cord-015365-iqdi99pd 847 15 erkrankten erkrankten FW cord-015365-iqdi99pd 847 16 Empfänger Empfänger NNP cord-015365-iqdi99pd 847 17 infundiert infundiert NN cord-015365-iqdi99pd 847 18 werden werden NNP cord-015365-iqdi99pd 847 19 . . . cord-015365-iqdi99pd 848 1 Hierbei Hierbei NNP cord-015365-iqdi99pd 848 2 ist ist NN cord-015365-iqdi99pd 848 3 das das NNP cord-015365-iqdi99pd 848 4 Therapieziel Therapieziel NNP cord-015365-iqdi99pd 849 1 eine eine NNP cord-015365-iqdi99pd 849 2 adaptive adaptive JJ cord-015365-iqdi99pd 849 3 Immunität Immunität NNP cord-015365-iqdi99pd 850 1 i i PRP cord-015365-iqdi99pd 851 1 m m NNP cord-015365-iqdi99pd 851 2 Empfänger Empfänger NNP cord-015365-iqdi99pd 851 3 zu zu NNP cord-015365-iqdi99pd 851 4 induzieren induzieren NNP cord-015365-iqdi99pd 851 5 . . . cord-015365-iqdi99pd 852 1 I -PRON- PRP cord-015365-iqdi99pd 852 2 m be VBP cord-015365-iqdi99pd 852 3 Rahmen Rahmen NNP cord-015365-iqdi99pd 852 4 einer einer NNP cord-015365-iqdi99pd 852 5 risikoadaptierten risikoadaptierten FW cord-015365-iqdi99pd 852 6 Therapie Therapie NNP cord-015365-iqdi99pd 852 7 wurde wurde NN cord-015365-iqdi99pd 852 8 bei bei NNP cord-015365-iqdi99pd 852 9 refraktären refraktären NNP cord-015365-iqdi99pd 853 1 Virusreaktivierungen Virusreaktivierungen NNP cord-015365-iqdi99pd 853 2 nach nach NNP cord-015365-iqdi99pd 853 3 Transplantation Transplantation NNP cord-015365-iqdi99pd 853 4 dieses diese VBD cord-015365-iqdi99pd 853 5 Therapieverfahren Therapieverfahren NNP cord-015365-iqdi99pd 853 6 angewendet angewendet NNP cord-015365-iqdi99pd 853 7 . . . cord-015365-iqdi99pd 854 1 Eine Eine NNP cord-015365-iqdi99pd 854 2 Ag Ag NNP cord-015365-iqdi99pd 854 3 - - HYPH cord-015365-iqdi99pd 854 4 spezifische spezifische NNP cord-015365-iqdi99pd 854 5 T T NNP cord-015365-iqdi99pd 854 6 - - HYPH cord-015365-iqdi99pd 854 7 Zellantwort Zellantwort NNP cord-015365-iqdi99pd 854 8 konnte konnte NNP cord-015365-iqdi99pd 855 1 i i PRP cord-015365-iqdi99pd 856 1 m m LS cord-015365-iqdi99pd 857 1 Empfänger Empfänger NNP cord-015365-iqdi99pd 857 2 gegen gegen NNP cord-015365-iqdi99pd 857 3 immundominante immundominante NNP cord-015365-iqdi99pd 857 4 Epitope Epitope NNP cord-015365-iqdi99pd 857 5 ( ( -LRB- cord-015365-iqdi99pd 857 6 pp65 pp65 RB cord-015365-iqdi99pd 857 7 fü fü IN cord-015365-iqdi99pd 858 1 r r LS cord-015365-iqdi99pd 858 2 CMV CMV NNP cord-015365-iqdi99pd 858 3 , , , cord-015365-iqdi99pd 858 4 Hexonprotein Hexonprotein NNP cord-015365-iqdi99pd 858 5 fü fü IN cord-015365-iqdi99pd 858 6 r r NN cord-015365-iqdi99pd 858 7 ADV ADV NNP cord-015365-iqdi99pd 859 1 und und NNP cord-015365-iqdi99pd 860 1 EBNA1 EBNA1 NNP cord-015365-iqdi99pd 861 1 fü fü IN cord-015365-iqdi99pd 862 1 r r NNP cord-015365-iqdi99pd 862 2 EBV EBV NNP cord-015365-iqdi99pd 862 3 ) ) -RRB- cord-015365-iqdi99pd 862 4 induziert induziert NNP cord-015365-iqdi99pd 863 1 werden werden NNP cord-015365-iqdi99pd 864 1 um um UH cord-015365-iqdi99pd 864 2 den den NNP cord-015365-iqdi99pd 864 3 Empfänger Empfänger NNP cord-015365-iqdi99pd 864 4 vor vor NNP cord-015365-iqdi99pd 864 5 Virus Virus NNP cord-015365-iqdi99pd 864 6 - - HYPH cord-015365-iqdi99pd 864 7 assoziierten assoziierten NNP cord-015365-iqdi99pd 864 8 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 864 9 zu zu NNP cord-015365-iqdi99pd 864 10 schü schü NNP cord-015365-iqdi99pd 864 11 tzen tzen NNP cord-015365-iqdi99pd 864 12 . . . cord-015365-iqdi99pd 865 1 Background background NN cord-015365-iqdi99pd 865 2 . . . cord-015365-iqdi99pd 866 1 We -PRON- PRP cord-015365-iqdi99pd 866 2 investigated investigate VBD cord-015365-iqdi99pd 866 3 the the DT cord-015365-iqdi99pd 866 4 safety safety NN cord-015365-iqdi99pd 866 5 and and CC cord-015365-iqdi99pd 866 6 efficacy efficacy NN cord-015365-iqdi99pd 866 7 of of IN cord-015365-iqdi99pd 866 8 T T NNP cord-015365-iqdi99pd 866 9 and and CC cord-015365-iqdi99pd 866 10 B B NNP cord-015365-iqdi99pd 866 11 cell cell NN cord-015365-iqdi99pd 866 12 depleted deplete VBD cord-015365-iqdi99pd 866 13 peripheral peripheral JJ cord-015365-iqdi99pd 866 14 stem stem NN cord-015365-iqdi99pd 866 15 cells cell NNS cord-015365-iqdi99pd 866 16 from from IN cord-015365-iqdi99pd 866 17 full full JJ cord-015365-iqdi99pd 866 18 haplotype haplotype NN cord-015365-iqdi99pd 866 19 mismatched mismatch VBD cord-015365-iqdi99pd 866 20 parental parental JJ cord-015365-iqdi99pd 866 21 donors donor NNS cord-015365-iqdi99pd 866 22 in in IN cord-015365-iqdi99pd 866 23 pediatric pediatric JJ cord-015365-iqdi99pd 866 24 patients patient NNS cord-015365-iqdi99pd 866 25 . . . cord-015365-iqdi99pd 867 1 Methods method NNS cord-015365-iqdi99pd 867 2 . . . cord-015365-iqdi99pd 868 1 Use use NN cord-015365-iqdi99pd 868 2 of of IN cord-015365-iqdi99pd 868 3 the the DT cord-015365-iqdi99pd 868 4 Clinimacs Clinimacs NNP cord-015365-iqdi99pd 868 5 system system NN cord-015365-iqdi99pd 868 6 and and CC cord-015365-iqdi99pd 868 7 CD3 CD3 NNP cord-015365-iqdi99pd 868 8 / / SYM cord-015365-iqdi99pd 868 9 CD19 CD19 NNP cord-015365-iqdi99pd 868 10 coated coat VBD cord-015365-iqdi99pd 868 11 magnetic magnetic JJ cord-015365-iqdi99pd 868 12 microbeads microbead NNS cord-015365-iqdi99pd 868 13 resulted result VBD cord-015365-iqdi99pd 868 14 in in IN cord-015365-iqdi99pd 868 15 a a DT cord-015365-iqdi99pd 868 16 4 4 CD cord-015365-iqdi99pd 868 17 log log NN cord-015365-iqdi99pd 868 18 depletion depletion NN cord-015365-iqdi99pd 868 19 of of IN cord-015365-iqdi99pd 868 20 T t NN cord-015365-iqdi99pd 868 21 cells cell NNS cord-015365-iqdi99pd 868 22 and and CC cord-015365-iqdi99pd 868 23 allowed allow VBN cord-015365-iqdi99pd 868 24 to to TO cord-015365-iqdi99pd 868 25 cotransfuse cotransfuse VB cord-015365-iqdi99pd 868 26 high high JJ cord-015365-iqdi99pd 868 27 numbers number NNS cord-015365-iqdi99pd 868 28 of of IN cord-015365-iqdi99pd 868 29 donor donor NN cord-015365-iqdi99pd 868 30 NK nk NN cord-015365-iqdi99pd 868 31 cells cell NNS cord-015365-iqdi99pd 868 32 ( ( -LRB- cord-015365-iqdi99pd 868 33 median median NN cord-015365-iqdi99pd 868 34 : : : cord-015365-iqdi99pd 868 35 107Â10 107â10 CD cord-015365-iqdi99pd 868 36 6 6 CD cord-015365-iqdi99pd 868 37 /kg /kg NFP cord-015365-iqdi99pd 868 38 ) ) -RRB- cord-015365-iqdi99pd 868 39 . . . cord-015365-iqdi99pd 869 1 TBI TBI NNP cord-015365-iqdi99pd 869 2 or or CC cord-015365-iqdi99pd 869 3 busulfan busulfan NNP cord-015365-iqdi99pd 869 4 based base VBN cord-015365-iqdi99pd 869 5 myeloablative myeloablative NNP cord-015365-iqdi99pd 869 6 regimens regimens NNPS cord-015365-iqdi99pd 869 7 or or CC cord-015365-iqdi99pd 869 8 a a DT cord-015365-iqdi99pd 869 9 melphalan melphalan NN cord-015365-iqdi99pd 869 10 based base VBN cord-015365-iqdi99pd 869 11 intensity intensity NN cord-015365-iqdi99pd 869 12 reduced reduce VBN cord-015365-iqdi99pd 869 13 regimen regimen NN cord-015365-iqdi99pd 869 14 were be VBD cord-015365-iqdi99pd 869 15 used use VBN cord-015365-iqdi99pd 869 16 . . . cord-015365-iqdi99pd 870 1 All all DT cord-015365-iqdi99pd 870 2 patients patient NNS cord-015365-iqdi99pd 870 3 underwent undergo VBD cord-015365-iqdi99pd 870 4 intensive intensive JJ cord-015365-iqdi99pd 870 5 pretreatment pretreatment NN cord-015365-iqdi99pd 870 6 according accord VBG cord-015365-iqdi99pd 870 7 to to IN cord-015365-iqdi99pd 870 8 current current JJ cord-015365-iqdi99pd 870 9 study study NN cord-015365-iqdi99pd 870 10 protocols protocol NNS cord-015365-iqdi99pd 870 11 ; ; : cord-015365-iqdi99pd 870 12 41/106 41/106 CD cord-015365-iqdi99pd 870 13 already already RB cord-015365-iqdi99pd 870 14 received receive VBN cord-015365-iqdi99pd 870 15 previous previous JJ cord-015365-iqdi99pd 870 16 allogeneic allogeneic NN cord-015365-iqdi99pd 870 17 transplantations transplantation NNS cord-015365-iqdi99pd 870 18 . . . cord-015365-iqdi99pd 871 1 The the DT cord-015365-iqdi99pd 871 2 diagnoses diagnosis NNS cord-015365-iqdi99pd 871 3 were be VBD cord-015365-iqdi99pd 871 4 : : : cord-015365-iqdi99pd 871 5 acute acute JJ cord-015365-iqdi99pd 871 6 leukemias leukemia NNS cord-015365-iqdi99pd 871 7 and and CC cord-015365-iqdi99pd 871 8 MDS MDS NNP cord-015365-iqdi99pd 871 9 ( ( -LRB- cord-015365-iqdi99pd 871 10 n n NN cord-015365-iqdi99pd 871 11 ¼ ¼ NNP cord-015365-iqdi99pd 871 12 60 60 CD cord-015365-iqdi99pd 871 13 ) ) -RRB- cord-015365-iqdi99pd 871 14 , , , cord-015365-iqdi99pd 871 15 solid solid JJ cord-015365-iqdi99pd 871 16 tumors tumor NNS cord-015365-iqdi99pd 871 17 ( ( -LRB- cord-015365-iqdi99pd 871 18 n n CC cord-015365-iqdi99pd 871 19 ¼ ¼ NNP cord-015365-iqdi99pd 871 20 32 32 CD cord-015365-iqdi99pd 871 21 ) ) -RRB- cord-015365-iqdi99pd 871 22 and and CC cord-015365-iqdi99pd 871 23 nonmalignant nonmalignant NNP cord-015365-iqdi99pd 871 24 diseases disease NNS cord-015365-iqdi99pd 871 25 ( ( -LRB- cord-015365-iqdi99pd 871 26 n n NN cord-015365-iqdi99pd 871 27 ¼ ¼ NNP cord-015365-iqdi99pd 871 28 14 14 CD cord-015365-iqdi99pd 871 29 ) ) -RRB- cord-015365-iqdi99pd 871 30 . . . cord-015365-iqdi99pd 872 1 Results result NNS cord-015365-iqdi99pd 872 2 . . . cord-015365-iqdi99pd 873 1 Primary primary JJ cord-015365-iqdi99pd 873 2 engraftment engraftment NN cord-015365-iqdi99pd 873 3 occurred occur VBD cord-015365-iqdi99pd 873 4 in in IN cord-015365-iqdi99pd 873 5 89 89 CD cord-015365-iqdi99pd 873 6 % % NN cord-015365-iqdi99pd 873 7 of of IN cord-015365-iqdi99pd 873 8 patients patient NNS cord-015365-iqdi99pd 873 9 . . . cord-015365-iqdi99pd 874 1 After after IN cord-015365-iqdi99pd 874 2 TLI TLI NNP cord-015365-iqdi99pd 874 3 based base VBD cord-015365-iqdi99pd 874 4 reconditioning reconditioning NN cord-015365-iqdi99pd 874 5 and and CC cord-015365-iqdi99pd 874 6 second second JJ cord-015365-iqdi99pd 874 7 haploidentical haploidentical JJ cord-015365-iqdi99pd 874 8 stem stem NN cord-015365-iqdi99pd 874 9 cell cell NN cord-015365-iqdi99pd 874 10 donation donation NN cord-015365-iqdi99pd 874 11 , , , cord-015365-iqdi99pd 874 12 final final JJ cord-015365-iqdi99pd 874 13 engraftment engraftment NN cord-015365-iqdi99pd 874 14 was be VBD cord-015365-iqdi99pd 874 15 achieved achieve VBN cord-015365-iqdi99pd 874 16 in in IN cord-015365-iqdi99pd 874 17 100 100 CD cord-015365-iqdi99pd 874 18 % % NN cord-015365-iqdi99pd 874 19 . . . cord-015365-iqdi99pd 875 1 Median median JJ cord-015365-iqdi99pd 875 2 time time NN cord-015365-iqdi99pd 875 3 to to TO cord-015365-iqdi99pd 875 4 reach reach VB cord-015365-iqdi99pd 875 5 > > XX cord-015365-iqdi99pd 875 6 500 500 CD cord-015365-iqdi99pd 875 7 neutrophiles neutrophile NNS cord-015365-iqdi99pd 875 8 / / SYM cord-015365-iqdi99pd 875 9 ml ml NN cord-015365-iqdi99pd 875 10 and and CC cord-015365-iqdi99pd 875 11 independence independence NN cord-015365-iqdi99pd 875 12 from from IN cord-015365-iqdi99pd 875 13 platelet platelet NN cord-015365-iqdi99pd 875 14 substitution substitution NN cord-015365-iqdi99pd 875 15 was be VBD cord-015365-iqdi99pd 875 16 10 10 CD cord-015365-iqdi99pd 875 17 ( ( -LRB- cord-015365-iqdi99pd 875 18 8 8 CD cord-015365-iqdi99pd 875 19 - - SYM cord-015365-iqdi99pd 875 20 15 15 CD cord-015365-iqdi99pd 875 21 ) ) -RRB- cord-015365-iqdi99pd 875 22 and and CC cord-015365-iqdi99pd 875 23 9 9 CD cord-015365-iqdi99pd 875 24 ( ( -LRB- cord-015365-iqdi99pd 875 25 5 5 CD cord-015365-iqdi99pd 875 26 - - SYM cord-015365-iqdi99pd 875 27 59 59 CD cord-015365-iqdi99pd 875 28 ) ) -RRB- cord-015365-iqdi99pd 875 29 days day NNS cord-015365-iqdi99pd 875 30 respectively respectively RB cord-015365-iqdi99pd 875 31 . . . cord-015365-iqdi99pd 876 1 35 35 CD cord-015365-iqdi99pd 876 2 % % NN cord-015365-iqdi99pd 876 3 of of IN cord-015365-iqdi99pd 876 4 patients patient NNS cord-015365-iqdi99pd 876 5 had have VBD cord-015365-iqdi99pd 876 6 no no DT cord-015365-iqdi99pd 876 7 GvHD gvhd NN cord-015365-iqdi99pd 876 8 , , , cord-015365-iqdi99pd 876 9 36 36 CD cord-015365-iqdi99pd 876 10 % % NN cord-015365-iqdi99pd 876 11 had have VBD cord-015365-iqdi99pd 876 12 grade grade NN cord-015365-iqdi99pd 876 13 I -PRON- PRP cord-015365-iqdi99pd 876 14 , , , cord-015365-iqdi99pd 876 15 23 23 CD cord-015365-iqdi99pd 876 16 % % NN cord-015365-iqdi99pd 876 17 had have VBD cord-015365-iqdi99pd 876 18 grade grade NN cord-015365-iqdi99pd 876 19 II II NNP cord-015365-iqdi99pd 876 20 and and CC cord-015365-iqdi99pd 876 21 4 4 CD cord-015365-iqdi99pd 876 22 % % NN cord-015365-iqdi99pd 876 23 had have VBD cord-015365-iqdi99pd 876 24 grade grade NN cord-015365-iqdi99pd 876 25 III III NNP cord-015365-iqdi99pd 876 26 . . . cord-015365-iqdi99pd 877 1 Chronic chronic NN cord-015365-iqdi99pd 877 2 limited limited JJ cord-015365-iqdi99pd 877 3 and and CC cord-015365-iqdi99pd 877 4 extensive extensive JJ cord-015365-iqdi99pd 877 5 GvHD gvhd NN cord-015365-iqdi99pd 877 6 was be VBD cord-015365-iqdi99pd 877 7 observed observe VBN cord-015365-iqdi99pd 877 8 in in IN cord-015365-iqdi99pd 877 9 8 8 CD cord-015365-iqdi99pd 877 10 and and CC cord-015365-iqdi99pd 877 11 11 11 CD cord-015365-iqdi99pd 877 12 % % NN cord-015365-iqdi99pd 877 13 . . . cord-015365-iqdi99pd 878 1 Transplant transplant NN cord-015365-iqdi99pd 878 2 related relate VBN cord-015365-iqdi99pd 878 3 mortality mortality NN cord-015365-iqdi99pd 878 4 was be VBD cord-015365-iqdi99pd 878 5 0 0 CD cord-015365-iqdi99pd 878 6 % % NN cord-015365-iqdi99pd 878 7 at at IN cord-015365-iqdi99pd 878 8 day day NN cord-015365-iqdi99pd 878 9 100 100 CD cord-015365-iqdi99pd 878 10 and and CC cord-015365-iqdi99pd 878 11 8 8 CD cord-015365-iqdi99pd 878 12 % % NN cord-015365-iqdi99pd 878 13 at at IN cord-015365-iqdi99pd 878 14 one one CD cord-015365-iqdi99pd 878 15 year year NN cord-015365-iqdi99pd 878 16 . . . cord-015365-iqdi99pd 879 1 Event event NN cord-015365-iqdi99pd 879 2 free free JJ cord-015365-iqdi99pd 879 3 survival survival NN cord-015365-iqdi99pd 879 4 at at IN cord-015365-iqdi99pd 879 5 3 3 CD cord-015365-iqdi99pd 879 6 years year NNS cord-015365-iqdi99pd 879 7 was be VBD cord-015365-iqdi99pd 879 8 66 66 CD cord-015365-iqdi99pd 879 9 % % NN cord-015365-iqdi99pd 879 10 for for IN cord-015365-iqdi99pd 879 11 patients patient NNS cord-015365-iqdi99pd 879 12 with with IN cord-015365-iqdi99pd 879 13 leukemias leukemia NNS cord-015365-iqdi99pd 879 14 in in IN cord-015365-iqdi99pd 879 15 any any DT cord-015365-iqdi99pd 879 16 CR cr NN cord-015365-iqdi99pd 879 17 and and CC cord-015365-iqdi99pd 879 18 80 80 CD cord-015365-iqdi99pd 879 19 % % NN cord-015365-iqdi99pd 879 20 for for IN cord-015365-iqdi99pd 879 21 patients patient NNS cord-015365-iqdi99pd 879 22 with with IN cord-015365-iqdi99pd 879 23 nonmalignant nonmalignant NNP cord-015365-iqdi99pd 879 24 diseases disease NNS cord-015365-iqdi99pd 879 25 . . . cord-015365-iqdi99pd 880 1 Over over IN cord-015365-iqdi99pd 880 2 all all DT cord-015365-iqdi99pd 880 3 survival survival NN cord-015365-iqdi99pd 880 4 at at IN cord-015365-iqdi99pd 880 5 2 2 CD cord-015365-iqdi99pd 880 6 years year NNS cord-015365-iqdi99pd 880 7 was be VBD cord-015365-iqdi99pd 880 8 20 20 CD cord-015365-iqdi99pd 880 9 % % NN cord-015365-iqdi99pd 880 10 for for IN cord-015365-iqdi99pd 880 11 patients patient NNS cord-015365-iqdi99pd 880 12 with with IN cord-015365-iqdi99pd 880 13 solid solid JJ cord-015365-iqdi99pd 880 14 tumors tumor NNS cord-015365-iqdi99pd 880 15 . . . cord-015365-iqdi99pd 881 1 Relapse relapse NN cord-015365-iqdi99pd 881 2 or or CC cord-015365-iqdi99pd 881 3 progression progression NN cord-015365-iqdi99pd 881 4 were be VBD cord-015365-iqdi99pd 881 5 the the DT cord-015365-iqdi99pd 881 6 major major JJ cord-015365-iqdi99pd 881 7 causes cause NNS cord-015365-iqdi99pd 881 8 of of IN cord-015365-iqdi99pd 881 9 death death NN cord-015365-iqdi99pd 881 10 . . . cord-015365-iqdi99pd 882 1 Thus thus RB cord-015365-iqdi99pd 882 2 , , , cord-015365-iqdi99pd 882 3 pilot pilot NN cord-015365-iqdi99pd 882 4 studies study NNS cord-015365-iqdi99pd 882 5 with with IN cord-015365-iqdi99pd 882 6 IL-15 IL-15 NNP cord-015365-iqdi99pd 882 7 stimulated stimulate VBD cord-015365-iqdi99pd 882 8 grafts graft NNS cord-015365-iqdi99pd 882 9 and and CC cord-015365-iqdi99pd 882 10 posttransplant posttransplant NN cord-015365-iqdi99pd 882 11 donor donor NN cord-015365-iqdi99pd 882 12 - - HYPH cord-015365-iqdi99pd 882 13 NK nk NN cord-015365-iqdi99pd 882 14 cell cell NN cord-015365-iqdi99pd 882 15 infusions infusion NNS cord-015365-iqdi99pd 882 16 were be VBD cord-015365-iqdi99pd 882 17 initiated initiate VBN cord-015365-iqdi99pd 882 18 and and CC cord-015365-iqdi99pd 882 19 are be VBP cord-015365-iqdi99pd 882 20 currently currently RB cord-015365-iqdi99pd 882 21 ongoing ongoing JJ cord-015365-iqdi99pd 882 22 . . . cord-015365-iqdi99pd 883 1 Conclusions conclusion NNS cord-015365-iqdi99pd 883 2 . . . cord-015365-iqdi99pd 884 1 Transplantation transplantation NN cord-015365-iqdi99pd 884 2 of of IN cord-015365-iqdi99pd 884 3 CD3/ CD3/ NNP cord-015365-iqdi99pd 885 1 CD19 CD19 NNP cord-015365-iqdi99pd 885 2 depleted deplete VBD cord-015365-iqdi99pd 885 3 haploidentical haploidentical JJ cord-015365-iqdi99pd 885 4 stem stem NN cord-015365-iqdi99pd 885 5 cells cell NNS cord-015365-iqdi99pd 885 6 resulted result VBD cord-015365-iqdi99pd 885 7 in in IN cord-015365-iqdi99pd 885 8 a a DT cord-015365-iqdi99pd 885 9 fast fast JJ cord-015365-iqdi99pd 885 10 recovery recovery NN cord-015365-iqdi99pd 885 11 of of IN cord-015365-iqdi99pd 885 12 neutrophiles neutrophile NNS cord-015365-iqdi99pd 885 13 and and CC cord-015365-iqdi99pd 885 14 platelets platelet NNS cord-015365-iqdi99pd 885 15 . . . cord-015365-iqdi99pd 886 1 Engraftment Engraftment NNP cord-015365-iqdi99pd 886 2 rates rate NNS cord-015365-iqdi99pd 886 3 similar similar JJ cord-015365-iqdi99pd 886 4 to to IN cord-015365-iqdi99pd 886 5 that that DT cord-015365-iqdi99pd 886 6 of of IN cord-015365-iqdi99pd 886 7 patients patient NNS cord-015365-iqdi99pd 886 8 with with IN cord-015365-iqdi99pd 886 9 myeloablative myeloablative JJ cord-015365-iqdi99pd 886 10 standard standard JJ cord-015365-iqdi99pd 886 11 conditioning conditioning NN cord-015365-iqdi99pd 886 12 and and CC cord-015365-iqdi99pd 886 13 positive positive JJ cord-015365-iqdi99pd 886 14 selected select VBN cord-015365-iqdi99pd 886 15 stem stem NN cord-015365-iqdi99pd 886 16 cells cell NNS cord-015365-iqdi99pd 886 17 could could MD cord-015365-iqdi99pd 886 18 be be VB cord-015365-iqdi99pd 886 19 achieved achieve VBN cord-015365-iqdi99pd 886 20 , , , cord-015365-iqdi99pd 886 21 possibly possibly RB cord-015365-iqdi99pd 886 22 due due IN cord-015365-iqdi99pd 886 23 to to IN cord-015365-iqdi99pd 886 24 a a DT cord-015365-iqdi99pd 886 25 graft graft NN cord-015365-iqdi99pd 886 26 facilitating facilitate VBG cord-015365-iqdi99pd 886 27 effect effect NN cord-015365-iqdi99pd 886 28 of of IN cord-015365-iqdi99pd 886 29 cotransfused cotransfuse VBN cord-015365-iqdi99pd 886 30 NK NK NNP cord-015365-iqdi99pd 886 31 cells cell NNS cord-015365-iqdi99pd 886 32 . . . cord-015365-iqdi99pd 887 1 The the DT cord-015365-iqdi99pd 887 2 regimen regimen NN cord-015365-iqdi99pd 887 3 helped help VBD cord-015365-iqdi99pd 887 4 to to TO cord-015365-iqdi99pd 887 5 minimize minimize VB cord-015365-iqdi99pd 887 6 TRM TRM NNP cord-015365-iqdi99pd 887 7 , , , cord-015365-iqdi99pd 887 8 despite despite IN cord-015365-iqdi99pd 887 9 intensive intensive JJ cord-015365-iqdi99pd 887 10 pretreatment pretreatment NN cord-015365-iqdi99pd 887 11 ( ( -LRB- cord-015365-iqdi99pd 887 12 including include VBG cord-015365-iqdi99pd 887 13 previous previous JJ cord-015365-iqdi99pd 887 14 transplantation transplantation NN cord-015365-iqdi99pd 887 15 ) ) -RRB- cord-015365-iqdi99pd 887 16 . . . cord-015365-iqdi99pd 888 1 However however RB cord-015365-iqdi99pd 888 2 , , , cord-015365-iqdi99pd 888 3 relapse relapse NN cord-015365-iqdi99pd 888 4 remains remain VBZ cord-015365-iqdi99pd 888 5 a a DT cord-015365-iqdi99pd 888 6 major major JJ cord-015365-iqdi99pd 888 7 problem problem NN cord-015365-iqdi99pd 888 8 and and CC cord-015365-iqdi99pd 888 9 further further JJ cord-015365-iqdi99pd 888 10 immunotherapeutic immunotherapeutic JJ cord-015365-iqdi99pd 888 11 elements element NNS cord-015365-iqdi99pd 888 12 have have VBP cord-015365-iqdi99pd 888 13 to to TO cord-015365-iqdi99pd 888 14 be be VB cord-015365-iqdi99pd 888 15 evaluated evaluate VBN cord-015365-iqdi99pd 888 16 . . . cord-015365-iqdi99pd 889 1 Antibody antibody NN cord-015365-iqdi99pd 889 2 based base VBN cord-015365-iqdi99pd 889 3 immunotherapy immunotherapy NN cord-015365-iqdi99pd 889 4 combined combine VBN cord-015365-iqdi99pd 889 5 with with IN cord-015365-iqdi99pd 889 6 haploidentical haploidentical JJ cord-015365-iqdi99pd 889 7 stem stem NN cord-015365-iqdi99pd 889 8 cell cell NN cord-015365-iqdi99pd 889 9 transplantation transplantation NN cord-015365-iqdi99pd 889 10 for for IN cord-015365-iqdi99pd 889 11 high high JJ cord-015365-iqdi99pd 889 12 risk risk NN cord-015365-iqdi99pd 889 13 neuroblastoma neuroblastoma NN cord-015365-iqdi99pd 889 14 Background Background NNP cord-015365-iqdi99pd 889 15 . . . cord-015365-iqdi99pd 890 1 Pediatric pediatric JJ cord-015365-iqdi99pd 890 2 patients patient NNS cord-015365-iqdi99pd 890 3 with with IN cord-015365-iqdi99pd 890 4 relapsed relapse VBN cord-015365-iqdi99pd 890 5 metastatic metastatic JJ cord-015365-iqdi99pd 890 6 neuroblastomas neuroblastomas NNP cord-015365-iqdi99pd 890 7 have have VBP cord-015365-iqdi99pd 890 8 a a DT cord-015365-iqdi99pd 890 9 poor poor JJ cord-015365-iqdi99pd 890 10 prognosis prognosis NN cord-015365-iqdi99pd 890 11 and and CC cord-015365-iqdi99pd 890 12 additional additional JJ cord-015365-iqdi99pd 890 13 therapeutic therapeutic JJ cord-015365-iqdi99pd 890 14 strategies strategy NNS cord-015365-iqdi99pd 890 15 are be VBP cord-015365-iqdi99pd 890 16 warranted warrant VBN cord-015365-iqdi99pd 890 17 . . . cord-015365-iqdi99pd 891 1 We -PRON- PRP cord-015365-iqdi99pd 891 2 present present VBP cord-015365-iqdi99pd 891 3 preliminary preliminary JJ cord-015365-iqdi99pd 891 4 results result NNS cord-015365-iqdi99pd 891 5 with with IN cord-015365-iqdi99pd 891 6 haploidentical haploidentical JJ cord-015365-iqdi99pd 891 7 stem stem NN cord-015365-iqdi99pd 891 8 cell cell NN cord-015365-iqdi99pd 891 9 transplantation transplantation NN cord-015365-iqdi99pd 891 10 and and CC cord-015365-iqdi99pd 891 11 posttransplant posttransplant NN cord-015365-iqdi99pd 891 12 immunotherapy immunotherapy NN cord-015365-iqdi99pd 891 13 with with IN cord-015365-iqdi99pd 891 14 an an DT cord-015365-iqdi99pd 891 15 anti anti JJ cord-015365-iqdi99pd 891 16 - - JJ cord-015365-iqdi99pd 891 17 GD2 gd2 JJ cord-015365-iqdi99pd 891 18 monoclonal monoclonal JJ cord-015365-iqdi99pd 891 19 antibody antibody NN cord-015365-iqdi99pd 891 20 ( ( -LRB- cord-015365-iqdi99pd 891 21 CH14.18 CH14.18 NNP cord-015365-iqdi99pd 891 22 CHO CHO NNP cord-015365-iqdi99pd 891 23 ) ) -RRB- cord-015365-iqdi99pd 891 24 . . . cord-015365-iqdi99pd 892 1 Methods method NNS cord-015365-iqdi99pd 892 2 . . . cord-015365-iqdi99pd 893 1 T T NNP cord-015365-iqdi99pd 893 2 and and CC cord-015365-iqdi99pd 893 3 B B NNP cord-015365-iqdi99pd 893 4 cell cell NN cord-015365-iqdi99pd 893 5 depleted deplete VBD cord-015365-iqdi99pd 893 6 haploidentical haploidentical JJ cord-015365-iqdi99pd 893 7 stem stem NN cord-015365-iqdi99pd 893 8 cells cell NNS cord-015365-iqdi99pd 893 9 in in IN cord-015365-iqdi99pd 893 10 combination combination NN cord-015365-iqdi99pd 893 11 with with IN cord-015365-iqdi99pd 893 12 a a DT cord-015365-iqdi99pd 893 13 toxicity toxicity NN cord-015365-iqdi99pd 893 14 reduced reduce VBN cord-015365-iqdi99pd 893 15 conditioning conditioning NN cord-015365-iqdi99pd 893 16 regime regime NN cord-015365-iqdi99pd 893 17 ( ( -LRB- cord-015365-iqdi99pd 893 18 melphalan melphalan NNP cord-015365-iqdi99pd 893 19 , , , cord-015365-iqdi99pd 893 20 thiotepa thiotepa NNP cord-015365-iqdi99pd 893 21 , , , cord-015365-iqdi99pd 893 22 fludarabine fludarabine NN cord-015365-iqdi99pd 893 23 and and CC cord-015365-iqdi99pd 893 24 OKT3 OKT3 NNP cord-015365-iqdi99pd 893 25 , , , cord-015365-iqdi99pd 893 26 now now RB cord-015365-iqdi99pd 893 27 substituted substitute VBN cord-015365-iqdi99pd 893 28 by by IN cord-015365-iqdi99pd 893 29 low low JJ cord-015365-iqdi99pd 893 30 dose dose NN cord-015365-iqdi99pd 893 31 ATG ATG NNP cord-015365-iqdi99pd 893 32 + + CC cord-015365-iqdi99pd 893 33 Fresenius Fresenius NNP cord-015365-iqdi99pd 893 34 ) ) -RRB- cord-015365-iqdi99pd 893 35 were be VBD cord-015365-iqdi99pd 893 36 used use VBN cord-015365-iqdi99pd 893 37 for for IN cord-015365-iqdi99pd 893 38 transplantation transplantation NN cord-015365-iqdi99pd 893 39 . . . cord-015365-iqdi99pd 894 1 In in IN cord-015365-iqdi99pd 894 2 a a DT cord-015365-iqdi99pd 894 3 subsequent subsequent JJ cord-015365-iqdi99pd 894 4 clinical clinical JJ cord-015365-iqdi99pd 894 5 trial trial NN cord-015365-iqdi99pd 894 6 , , , cord-015365-iqdi99pd 894 7 we -PRON- PRP cord-015365-iqdi99pd 894 8 evaluate evaluate VBP cord-015365-iqdi99pd 894 9 the the DT cord-015365-iqdi99pd 894 10 feasibility feasibility NN cord-015365-iqdi99pd 894 11 and and CC cord-015365-iqdi99pd 894 12 safety safety NN cord-015365-iqdi99pd 894 13 of of IN cord-015365-iqdi99pd 894 14 antibody antibody NN cord-015365-iqdi99pd 894 15 infusions infusion NNS cord-015365-iqdi99pd 894 16 against against IN cord-015365-iqdi99pd 894 17 the the DT cord-015365-iqdi99pd 894 18 neuroblastoma neuroblastoma NN cord-015365-iqdi99pd 894 19 antigen antigen NN cord-015365-iqdi99pd 894 20 GD2 GD2 NNP cord-015365-iqdi99pd 894 21 : : : cord-015365-iqdi99pd 894 22 6 6 CD cord-015365-iqdi99pd 894 23 cycles cycle NNS cord-015365-iqdi99pd 894 24 of of IN cord-015365-iqdi99pd 894 25 mAb mab NN cord-015365-iqdi99pd 894 26 CH14.18 CH14.18 NNS cord-015365-iqdi99pd 894 27 / / SYM cord-015365-iqdi99pd 894 28 CHO CHO NNP cord-015365-iqdi99pd 894 29 ( ( -LRB- cord-015365-iqdi99pd 894 30 20 20 CD cord-015365-iqdi99pd 894 31 mg mg NNP cord-015365-iqdi99pd 894 32 / / SYM cord-015365-iqdi99pd 894 33 m m NN cord-015365-iqdi99pd 894 34 2 2 CD cord-015365-iqdi99pd 894 35 infusion infusion NN cord-015365-iqdi99pd 894 36 for for IN cord-015365-iqdi99pd 894 37 5 5 CD cord-015365-iqdi99pd 894 38 days day NNS cord-015365-iqdi99pd 894 39 ; ; : cord-015365-iqdi99pd 894 40 in in IN cord-015365-iqdi99pd 894 41 cycles cycle NNS cord-015365-iqdi99pd 894 42 4 4 CD cord-015365-iqdi99pd 894 43 - - SYM cord-015365-iqdi99pd 894 44 6 6 CD cord-015365-iqdi99pd 894 45 , , , cord-015365-iqdi99pd 894 46 1Â10 1â10 CD cord-015365-iqdi99pd 894 47 6 6 CD cord-015365-iqdi99pd 894 48 units unit NNS cord-015365-iqdi99pd 894 49 / / SYM cord-015365-iqdi99pd 894 50 m m NN cord-015365-iqdi99pd 894 51 2 2 CD cord-015365-iqdi99pd 894 52 interleukin interleukin NN cord-015365-iqdi99pd 894 53 2 2 CD cord-015365-iqdi99pd 894 54 ( ( -LRB- cord-015365-iqdi99pd 894 55 IL-2 IL-2 NNP cord-015365-iqdi99pd 894 56 ) ) -RRB- cord-015365-iqdi99pd 894 57 is be VBZ cord-015365-iqdi99pd 894 58 given give VBN cord-015365-iqdi99pd 894 59 additionally additionally RB cord-015365-iqdi99pd 894 60 on on IN cord-015365-iqdi99pd 894 61 days day NNS cord-015365-iqdi99pd 894 62 6 6 CD cord-015365-iqdi99pd 894 63 , , , cord-015365-iqdi99pd 894 64 8 8 CD cord-015365-iqdi99pd 894 65 and and CC cord-015365-iqdi99pd 894 66 10 10 CD cord-015365-iqdi99pd 894 67 ) ) -RRB- cord-015365-iqdi99pd 894 68 . . . cord-015365-iqdi99pd 895 1 Results result NNS cord-015365-iqdi99pd 895 2 . . . cord-015365-iqdi99pd 896 1 Haplotransplantation Haplotransplantation NNP cord-015365-iqdi99pd 896 2 without without IN cord-015365-iqdi99pd 896 3 subsequent subsequent JJ cord-015365-iqdi99pd 896 4 antibody antibody NN cord-015365-iqdi99pd 896 5 infusions infusion NNS cord-015365-iqdi99pd 896 6 resulted result VBD cord-015365-iqdi99pd 896 7 in in IN cord-015365-iqdi99pd 896 8 a a DT cord-015365-iqdi99pd 896 9 2-year 2-year NN cord-015365-iqdi99pd 896 10 over over IN cord-015365-iqdi99pd 896 11 all all DT cord-015365-iqdi99pd 896 12 survival survival NN cord-015365-iqdi99pd 896 13 of of IN cord-015365-iqdi99pd 896 14 28 28 CD cord-015365-iqdi99pd 896 15 % % NN cord-015365-iqdi99pd 896 16 . . . cord-015365-iqdi99pd 897 1 TRM TRM NNP cord-015365-iqdi99pd 897 2 at at IN cord-015365-iqdi99pd 897 3 day day NN cord-015365-iqdi99pd 897 4 100 100 CD cord-015365-iqdi99pd 897 5 was be VBD cord-015365-iqdi99pd 897 6 0 0 CD cord-015365-iqdi99pd 897 7 % % NN cord-015365-iqdi99pd 897 8 , , , cord-015365-iqdi99pd 897 9 single single JJ cord-015365-iqdi99pd 897 10 cause cause NN cord-015365-iqdi99pd 897 11 of of IN cord-015365-iqdi99pd 897 12 death death NN cord-015365-iqdi99pd 897 13 was be VBD cord-015365-iqdi99pd 897 14 relapse/ relapse/ NN cord-015365-iqdi99pd 897 15 progression progression NN cord-015365-iqdi99pd 897 16 . . . cord-015365-iqdi99pd 898 1 Thus thus RB cord-015365-iqdi99pd 898 2 , , , cord-015365-iqdi99pd 898 3 transplantation transplantation NN cord-015365-iqdi99pd 898 4 itself -PRON- PRP cord-015365-iqdi99pd 898 5 seems seem VBZ cord-015365-iqdi99pd 898 6 to to TO cord-015365-iqdi99pd 898 7 be be VB cord-015365-iqdi99pd 898 8 not not RB cord-015365-iqdi99pd 898 9 sufficient sufficient JJ cord-015365-iqdi99pd 898 10 for for IN cord-015365-iqdi99pd 898 11 most most JJS cord-015365-iqdi99pd 898 12 patients patient NNS cord-015365-iqdi99pd 898 13 but but CC cord-015365-iqdi99pd 898 14 may may MD cord-015365-iqdi99pd 898 15 be be VB cord-015365-iqdi99pd 898 16 a a DT cord-015365-iqdi99pd 898 17 platform platform NN cord-015365-iqdi99pd 898 18 for for IN cord-015365-iqdi99pd 898 19 further further JJ cord-015365-iqdi99pd 898 20 immunotherapies immunotherapy NNS cord-015365-iqdi99pd 898 21 on on IN cord-015365-iqdi99pd 898 22 the the DT cord-015365-iqdi99pd 898 23 basis basis NN cord-015365-iqdi99pd 898 24 of of IN cord-015365-iqdi99pd 898 25 antibody antibody NN cord-015365-iqdi99pd 898 26 dependent dependent JJ cord-015365-iqdi99pd 898 27 NK NK NNP cord-015365-iqdi99pd 898 28 cell cell NN cord-015365-iqdi99pd 898 29 mediated mediate VBN cord-015365-iqdi99pd 898 30 cytotoxicity cytotoxicity NN cord-015365-iqdi99pd 898 31 and and CC cord-015365-iqdi99pd 898 32 complement complement VB cord-015365-iqdi99pd 898 33 lysis lysis NN cord-015365-iqdi99pd 898 34 . . . cord-015365-iqdi99pd 899 1 12 12 CD cord-015365-iqdi99pd 899 2 patients patient NNS cord-015365-iqdi99pd 899 3 have have VBP cord-015365-iqdi99pd 899 4 been be VBN cord-015365-iqdi99pd 899 5 enrolled enrol VBN cord-015365-iqdi99pd 899 6 in in IN cord-015365-iqdi99pd 899 7 our -PRON- PRP$ cord-015365-iqdi99pd 899 8 CH14.18 CH14.18 NNP cord-015365-iqdi99pd 899 9 study study NN cord-015365-iqdi99pd 899 10 and and CC cord-015365-iqdi99pd 899 11 received receive VBD cord-015365-iqdi99pd 899 12 a a DT cord-015365-iqdi99pd 899 13 total total NN cord-015365-iqdi99pd 899 14 of of IN cord-015365-iqdi99pd 899 15 42 42 CD cord-015365-iqdi99pd 899 16 antibody antibody NN cord-015365-iqdi99pd 899 17 cycles cycle NNS cord-015365-iqdi99pd 899 18 . . . cord-015365-iqdi99pd 900 1 Side side JJ cord-015365-iqdi99pd 900 2 effects effect NNS cord-015365-iqdi99pd 900 3 were be VBD cord-015365-iqdi99pd 900 4 : : : cord-015365-iqdi99pd 900 5 inflammation inflammation NN cord-015365-iqdi99pd 900 6 symptoms symptom NNS cord-015365-iqdi99pd 900 7 ( ( -LRB- cord-015365-iqdi99pd 900 8 pain pain NN cord-015365-iqdi99pd 900 9 42/42 42/42 CD cord-015365-iqdi99pd 900 10 , , , cord-015365-iqdi99pd 900 11 fever fever NN cord-015365-iqdi99pd 900 12 36/42 36/42 CD cord-015365-iqdi99pd 900 13 and and CC cord-015365-iqdi99pd 900 14 CRP CRP NNP cord-015365-iqdi99pd 900 15 elevation elevation NN cord-015365-iqdi99pd 900 16 35/42 35/42 CD cord-015365-iqdi99pd 900 17 cycles cycle NNS cord-015365-iqdi99pd 900 18 ) ) -RRB- cord-015365-iqdi99pd 900 19 , , , cord-015365-iqdi99pd 900 20 which which WDT cord-015365-iqdi99pd 900 21 decreased decrease VBD cord-015365-iqdi99pd 900 22 or or CC cord-015365-iqdi99pd 900 23 disappeared disappear VBD cord-015365-iqdi99pd 900 24 by by IN cord-015365-iqdi99pd 900 25 increasing increase VBG cord-015365-iqdi99pd 900 26 cycle cycle NN cord-015365-iqdi99pd 900 27 numbers number NNS cord-015365-iqdi99pd 900 28 ; ; : cord-015365-iqdi99pd 900 29 accommodation accommodation NN cord-015365-iqdi99pd 900 30 disturbance disturbance NN cord-015365-iqdi99pd 900 31 ( ( -LRB- cord-015365-iqdi99pd 900 32 n n NN cord-015365-iqdi99pd 900 33 ¼ ¼ NNP cord-015365-iqdi99pd 900 34 3 3 CD cord-015365-iqdi99pd 900 35 ) ) -RRB- cord-015365-iqdi99pd 900 36 , , , cord-015365-iqdi99pd 900 37 seizures seizure NNS cord-015365-iqdi99pd 900 38 ( ( -LRB- cord-015365-iqdi99pd 900 39 n n CC cord-015365-iqdi99pd 900 40 ¼ ¼ NNP cord-015365-iqdi99pd 900 41 2 2 CD cord-015365-iqdi99pd 900 42 ) ) -RRB- cord-015365-iqdi99pd 900 43 , , , cord-015365-iqdi99pd 900 44 loss loss NN cord-015365-iqdi99pd 900 45 of of IN cord-015365-iqdi99pd 900 46 weight weight NN cord-015365-iqdi99pd 900 47 ( ( -LRB- cord-015365-iqdi99pd 900 48 n n NN cord-015365-iqdi99pd 900 49 ¼ ¼ NNP cord-015365-iqdi99pd 900 50 2 2 CD cord-015365-iqdi99pd 900 51 ) ) -RRB- cord-015365-iqdi99pd 900 52 . . . cord-015365-iqdi99pd 901 1 During during IN cord-015365-iqdi99pd 901 2 antibody antibody NN cord-015365-iqdi99pd 901 3 infusions infusion NNS cord-015365-iqdi99pd 901 4 , , , cord-015365-iqdi99pd 901 5 endogenous endogenous JJ cord-015365-iqdi99pd 901 6 secretion secretion NN cord-015365-iqdi99pd 901 7 of of IN cord-015365-iqdi99pd 901 8 IL-2 il-2 NN cord-015365-iqdi99pd 901 9 in in IN cord-015365-iqdi99pd 901 10 the the DT cord-015365-iqdi99pd 901 11 patients patient NNS cord-015365-iqdi99pd 901 12 was be VBD cord-015365-iqdi99pd 901 13 significantly significantly RB cord-015365-iqdi99pd 901 14 increased increase VBN cord-015365-iqdi99pd 901 15 ( ( -LRB- cord-015365-iqdi99pd 901 16 880 880 CD cord-015365-iqdi99pd 901 17 U/ U/ NNP cord-015365-iqdi99pd 901 18 ml ml XX cord-015365-iqdi99pd 901 19 prior prior RB cord-015365-iqdi99pd 901 20 vs. vs. NN cord-015365-iqdi99pd 901 21 1580 1580 CD cord-015365-iqdi99pd 901 22 U U NNP cord-015365-iqdi99pd 901 23 / / SYM cord-015365-iqdi99pd 901 24 ml ml NN cord-015365-iqdi99pd 901 25 post post NN cord-015365-iqdi99pd 901 26 ) ) -RRB- cord-015365-iqdi99pd 901 27 , , , cord-015365-iqdi99pd 901 28 which which WDT cord-015365-iqdi99pd 901 29 resulted result VBD cord-015365-iqdi99pd 901 30 in in IN cord-015365-iqdi99pd 901 31 an an DT cord-015365-iqdi99pd 901 32 also also RB cord-015365-iqdi99pd 901 33 significantly significantly RB cord-015365-iqdi99pd 901 34 increased increase VBN cord-015365-iqdi99pd 901 35 stimulation stimulation NN cord-015365-iqdi99pd 901 36 of of IN cord-015365-iqdi99pd 901 37 natural natural JJ cord-015365-iqdi99pd 901 38 killer killer NN cord-015365-iqdi99pd 901 39 ( ( -LRB- cord-015365-iqdi99pd 901 40 NK NK NNP cord-015365-iqdi99pd 901 41 ) ) -RRB- cord-015365-iqdi99pd 901 42 cells cell NNS cord-015365-iqdi99pd 901 43 in in IN cord-015365-iqdi99pd 901 44 peripheral peripheral JJ cord-015365-iqdi99pd 901 45 blood blood NN cord-015365-iqdi99pd 901 46 ( ( -LRB- cord-015365-iqdi99pd 901 47 measured measure VBN cord-015365-iqdi99pd 901 48 by by IN cord-015365-iqdi99pd 901 49 CD69 CD69 NNP cord-015365-iqdi99pd 901 50 expression expression NN cord-015365-iqdi99pd 901 51 ) ) -RRB- cord-015365-iqdi99pd 901 52 . . . cord-015365-iqdi99pd 902 1 Predominantly predominantly RB cord-015365-iqdi99pd 902 2 ADCC ADCC NNP cord-015365-iqdi99pd 902 3 exerting exert VBG cord-015365-iqdi99pd 902 4 NK NK NNP cord-015365-iqdi99pd 902 5 cells cell NNS cord-015365-iqdi99pd 902 6 ( ( -LRB- cord-015365-iqdi99pd 902 7 with with IN cord-015365-iqdi99pd 902 8 expression expression NN cord-015365-iqdi99pd 902 9 of of IN cord-015365-iqdi99pd 902 10 the the DT cord-015365-iqdi99pd 902 11 Fc Fc NNP cord-015365-iqdi99pd 902 12 - - HYPH cord-015365-iqdi99pd 902 13 gamma gamma NN cord-015365-iqdi99pd 902 14 receptor receptor NN cord-015365-iqdi99pd 902 15 CD16 CD16 NNP cord-015365-iqdi99pd 902 16 ) ) -RRB- cord-015365-iqdi99pd 902 17 were be VBD cord-015365-iqdi99pd 902 18 stimulated stimulate VBN cord-015365-iqdi99pd 902 19 . . . cord-015365-iqdi99pd 903 1 In in IN cord-015365-iqdi99pd 903 2 3 3 CD cord-015365-iqdi99pd 903 3 out out IN cord-015365-iqdi99pd 903 4 of of IN cord-015365-iqdi99pd 903 5 5 5 CD cord-015365-iqdi99pd 903 6 investigated investigate VBN cord-015365-iqdi99pd 903 7 patients patient NNS cord-015365-iqdi99pd 903 8 , , , cord-015365-iqdi99pd 903 9 NK NK NNP cord-015365-iqdi99pd 903 10 cell cell NN cord-015365-iqdi99pd 903 11 and and CC cord-015365-iqdi99pd 903 12 complement complement NN cord-015365-iqdi99pd 903 13 mediated mediate VBN cord-015365-iqdi99pd 903 14 anti anti JJ cord-015365-iqdi99pd 903 15 - - JJ cord-015365-iqdi99pd 903 16 tumor tumor JJ cord-015365-iqdi99pd 903 17 effects effect NNS cord-015365-iqdi99pd 903 18 against against IN cord-015365-iqdi99pd 903 19 neuroblastoma neuroblastoma NN cord-015365-iqdi99pd 903 20 cells cell NNS cord-015365-iqdi99pd 903 21 were be VBD cord-015365-iqdi99pd 903 22 detectable detectable JJ cord-015365-iqdi99pd 903 23 . . . cord-015365-iqdi99pd 904 1 5 5 CD cord-015365-iqdi99pd 904 2 patients patient NNS cord-015365-iqdi99pd 904 3 finished finish VBD cord-015365-iqdi99pd 904 4 the the DT cord-015365-iqdi99pd 904 5 protocol protocol NN cord-015365-iqdi99pd 904 6 so so RB cord-015365-iqdi99pd 904 7 far far RB cord-015365-iqdi99pd 904 8 and and CC cord-015365-iqdi99pd 904 9 were be VBD cord-015365-iqdi99pd 904 10 evaluable evaluable JJ cord-015365-iqdi99pd 904 11 after after IN cord-015365-iqdi99pd 904 12 6 6 CD cord-015365-iqdi99pd 904 13 cycles cycle NNS cord-015365-iqdi99pd 904 14 . . . cord-015365-iqdi99pd 905 1 3/5 3/5 CD cord-015365-iqdi99pd 905 2 patients patient NNS cord-015365-iqdi99pd 905 3 responded respond VBD cord-015365-iqdi99pd 905 4 and and CC cord-015365-iqdi99pd 905 5 reached reach VBD cord-015365-iqdi99pd 905 6 a a DT cord-015365-iqdi99pd 905 7 complete complete JJ cord-015365-iqdi99pd 905 8 remission remission NN cord-015365-iqdi99pd 905 9 or or CC cord-015365-iqdi99pd 905 10 improved improve VBD cord-015365-iqdi99pd 905 11 their -PRON- PRP$ cord-015365-iqdi99pd 905 12 partial partial JJ cord-015365-iqdi99pd 905 13 remission remission NN cord-015365-iqdi99pd 905 14 , , , cord-015365-iqdi99pd 905 15 2 2 CD cord-015365-iqdi99pd 905 16 patients patient NNS cord-015365-iqdi99pd 905 17 progressed progress VBD cord-015365-iqdi99pd 905 18 . . . cord-015365-iqdi99pd 906 1 Conclusions conclusion NNS cord-015365-iqdi99pd 906 2 . . . cord-015365-iqdi99pd 907 1 Preliminary preliminary JJ cord-015365-iqdi99pd 907 2 results result NNS cord-015365-iqdi99pd 907 3 of of IN cord-015365-iqdi99pd 907 4 our -PRON- PRP$ cord-015365-iqdi99pd 907 5 ongoing ongoing JJ cord-015365-iqdi99pd 907 6 study study NN cord-015365-iqdi99pd 907 7 suggest suggest VBP cord-015365-iqdi99pd 907 8 an an DT cord-015365-iqdi99pd 907 9 anti anti JJ cord-015365-iqdi99pd 907 10 - - JJ cord-015365-iqdi99pd 907 11 tumor tumor JJ cord-015365-iqdi99pd 907 12 effect effect NN cord-015365-iqdi99pd 907 13 of of IN cord-015365-iqdi99pd 907 14 the the DT cord-015365-iqdi99pd 907 15 donor donor NN cord-015365-iqdi99pd 907 16 derived derive VBN cord-015365-iqdi99pd 907 17 immune immune JJ cord-015365-iqdi99pd 907 18 system system NN cord-015365-iqdi99pd 907 19 in in IN cord-015365-iqdi99pd 907 20 vitro vitro FW cord-015365-iqdi99pd 907 21 and and CC cord-015365-iqdi99pd 907 22 in in IN cord-015365-iqdi99pd 907 23 vivo vivo NNP cord-015365-iqdi99pd 907 24 . . . cord-015365-iqdi99pd 908 1 SCT SCT NNP cord-015365-iqdi99pd 908 2 from from IN cord-015365-iqdi99pd 908 3 a a DT cord-015365-iqdi99pd 908 4 matched match VBN cord-015365-iqdi99pd 908 5 sibling sibling NN cord-015365-iqdi99pd 908 6 donor donor NN cord-015365-iqdi99pd 908 7 ( ( -LRB- cord-015365-iqdi99pd 908 8 MSD MSD NNP cord-015365-iqdi99pd 908 9 ) ) -RRB- cord-015365-iqdi99pd 908 10 is be VBZ cord-015365-iqdi99pd 908 11 the the DT cord-015365-iqdi99pd 908 12 treatment treatment NN cord-015365-iqdi99pd 908 13 of of IN cord-015365-iqdi99pd 908 14 choice choice NN cord-015365-iqdi99pd 908 15 for for IN cord-015365-iqdi99pd 908 16 children child NNS cord-015365-iqdi99pd 908 17 with with IN cord-015365-iqdi99pd 908 18 SAA SAA NNP cord-015365-iqdi99pd 908 19 , , , cord-015365-iqdi99pd 908 20 however however RB cord-015365-iqdi99pd 908 21 limited limit VBN cord-015365-iqdi99pd 908 22 by by IN cord-015365-iqdi99pd 908 23 donor donor NN cord-015365-iqdi99pd 908 24 availability availability NN cord-015365-iqdi99pd 908 25 . . . cord-015365-iqdi99pd 909 1 Immunosuppression Immunosuppression NNP cord-015365-iqdi99pd 909 2 ( ( -LRB- cord-015365-iqdi99pd 909 3 IS be VBZ cord-015365-iqdi99pd 909 4 ) ) -RRB- cord-015365-iqdi99pd 909 5 as as IN cord-015365-iqdi99pd 909 6 the the DT cord-015365-iqdi99pd 909 7 other other JJ cord-015365-iqdi99pd 909 8 option option NN cord-015365-iqdi99pd 909 9 has have VBZ cord-015365-iqdi99pd 909 10 the the DT cord-015365-iqdi99pd 909 11 disadvantage disadvantage NN cord-015365-iqdi99pd 909 12 of of IN cord-015365-iqdi99pd 909 13 high high JJ cord-015365-iqdi99pd 909 14 treatment treatment NN cord-015365-iqdi99pd 909 15 failures failure NNS cord-015365-iqdi99pd 909 16 . . . cord-015365-iqdi99pd 910 1 7 7 CD cord-015365-iqdi99pd 910 2 patients patient NNS cord-015365-iqdi99pd 910 3 with with IN cord-015365-iqdi99pd 910 4 SAA SAA NNP cord-015365-iqdi99pd 910 5 without without IN cord-015365-iqdi99pd 910 6 a a DT cord-015365-iqdi99pd 910 7 MSD msd NN cord-015365-iqdi99pd 910 8 and and CC cord-015365-iqdi99pd 910 9 refractory refractory JJ cord-015365-iqdi99pd 910 10 to to IN cord-015365-iqdi99pd 910 11 previous previous JJ cord-015365-iqdi99pd 910 12 IS is NN cord-015365-iqdi99pd 910 13 , , , cord-015365-iqdi99pd 910 14 median median JJ cord-015365-iqdi99pd 910 15 age age NN cord-015365-iqdi99pd 910 16 11 11 CD cord-015365-iqdi99pd 910 17 years year NNS cord-015365-iqdi99pd 910 18 ( ( -LRB- cord-015365-iqdi99pd 910 19 5 5 CD cord-015365-iqdi99pd 910 20 - - SYM cord-015365-iqdi99pd 910 21 16 16 CD cord-015365-iqdi99pd 910 22 ) ) -RRB- cord-015365-iqdi99pd 910 23 , , , cord-015365-iqdi99pd 910 24 median median JJ cord-015365-iqdi99pd 910 25 interval interval NN cord-015365-iqdi99pd 910 26 from from IN cord-015365-iqdi99pd 910 27 diagnosis diagnosis NN cord-015365-iqdi99pd 910 28 to to IN cord-015365-iqdi99pd 910 29 SCT SCT NNP cord-015365-iqdi99pd 910 30 12 12 CD cord-015365-iqdi99pd 910 31 months month NNS cord-015365-iqdi99pd 910 32 ( ( -LRB- cord-015365-iqdi99pd 910 33 3 3 CD cord-015365-iqdi99pd 910 34 - - SYM cord-015365-iqdi99pd 910 35 155 155 CD cord-015365-iqdi99pd 910 36 ) ) -RRB- cord-015365-iqdi99pd 910 37 and and CC cord-015365-iqdi99pd 910 38 median median JJ cord-015365-iqdi99pd 910 39 number number NN cord-015365-iqdi99pd 910 40 of of IN cord-015365-iqdi99pd 910 41 transfusions transfusion NNS cord-015365-iqdi99pd 910 42 before before IN cord-015365-iqdi99pd 910 43 SCT SCT NNP cord-015365-iqdi99pd 910 44 55 55 CD cord-015365-iqdi99pd 910 45 ( ( -LRB- cord-015365-iqdi99pd 910 46 18 18 CD cord-015365-iqdi99pd 910 47 - - SYM cord-015365-iqdi99pd 910 48 116 116 CD cord-015365-iqdi99pd 910 49 ) ) -RRB- cord-015365-iqdi99pd 910 50 underwent undergo VBD cord-015365-iqdi99pd 910 51 alternative alternative JJ cord-015365-iqdi99pd 910 52 donor donor NN cord-015365-iqdi99pd 910 53 SCT SCT NNP cord-015365-iqdi99pd 910 54 . . . cord-015365-iqdi99pd 911 1 Donors donor NNS cord-015365-iqdi99pd 911 2 were be VBD cord-015365-iqdi99pd 911 3 matched match VBN cord-015365-iqdi99pd 911 4 unrelated unrelated JJ cord-015365-iqdi99pd 911 5 ( ( -LRB- cord-015365-iqdi99pd 911 6 MUD mud NN cord-015365-iqdi99pd 911 7 ) ) -RRB- cord-015365-iqdi99pd 911 8 ( ( -LRB- cord-015365-iqdi99pd 911 9 n n CC cord-015365-iqdi99pd 911 10 ¼ ¼ NNP cord-015365-iqdi99pd 911 11 4 4 CD cord-015365-iqdi99pd 911 12 ) ) -RRB- cord-015365-iqdi99pd 911 13 , , . cord-015365-iqdi99pd 912 1 mismatched mismatched JJ cord-015365-iqdi99pd 912 2 unrelated unrelated JJ cord-015365-iqdi99pd 912 3 ( ( -LRB- cord-015365-iqdi99pd 912 4 n n CC cord-015365-iqdi99pd 912 5 ¼ ¼ NNP cord-015365-iqdi99pd 912 6 2 2 CD cord-015365-iqdi99pd 912 7 ) ) -RRB- cord-015365-iqdi99pd 912 8 and and CC cord-015365-iqdi99pd 912 9 haploidentical haploidentical NNP cord-015365-iqdi99pd 912 10 ( ( -LRB- cord-015365-iqdi99pd 912 11 n n NNP cord-015365-iqdi99pd 912 12 ¼ ¼ NNP cord-015365-iqdi99pd 912 13 1 1 CD cord-015365-iqdi99pd 912 14 ) ) -RRB- cord-015365-iqdi99pd 912 15 . . . cord-015365-iqdi99pd 913 1 Conditioning conditioning NN cord-015365-iqdi99pd 913 2 regimens regimen NNS cord-015365-iqdi99pd 913 3 contained contain VBD cord-015365-iqdi99pd 913 4 cyclophosphamide cyclophosphamide NN cord-015365-iqdi99pd 913 5 and and CC cord-015365-iqdi99pd 913 6 either either CC cord-015365-iqdi99pd 913 7 muromonab muromonab NN cord-015365-iqdi99pd 913 8 - - HYPH cord-015365-iqdi99pd 913 9 CD3 CD3 NNP cord-015365-iqdi99pd 913 10 or or CC cord-015365-iqdi99pd 913 11 anti anti JJ cord-015365-iqdi99pd 913 12 - - JJ cord-015365-iqdi99pd 913 13 thymocyte thymocyte JJ cord-015365-iqdi99pd 913 14 globulin globulin NN cord-015365-iqdi99pd 913 15 ( ( -LRB- cord-015365-iqdi99pd 913 16 ATG ATG NNP cord-015365-iqdi99pd 913 17 ) ) -RRB- cord-015365-iqdi99pd 913 18 in in IN cord-015365-iqdi99pd 913 19 7/7 7/7 CD cord-015365-iqdi99pd 913 20 , , , cord-015365-iqdi99pd 913 21 thiotepa thiotepa JJ cord-015365-iqdi99pd 913 22 ( ( -LRB- cord-015365-iqdi99pd 913 23 THT THT NNP cord-015365-iqdi99pd 913 24 ) ) -RRB- cord-015365-iqdi99pd 913 25 in in IN cord-015365-iqdi99pd 913 26 6/7 6/7 CD cord-015365-iqdi99pd 913 27 , , , cord-015365-iqdi99pd 913 28 fludarabine fludarabine NNP cord-015365-iqdi99pd 913 29 ( ( -LRB- cord-015365-iqdi99pd 913 30 FLU flu NN cord-015365-iqdi99pd 913 31 ) ) -RRB- cord-015365-iqdi99pd 913 32 in in IN cord-015365-iqdi99pd 913 33 5/7 5/7 CD cord-015365-iqdi99pd 913 34 and and CC cord-015365-iqdi99pd 913 35 total total JJ cord-015365-iqdi99pd 913 36 lymphoid lymphoid JJ cord-015365-iqdi99pd 913 37 irradiation irradiation NN cord-015365-iqdi99pd 913 38 in in IN cord-015365-iqdi99pd 913 39 2/7 2/7 CD cord-015365-iqdi99pd 913 40 patients patient NNS cord-015365-iqdi99pd 913 41 . . . cord-015365-iqdi99pd 914 1 Grafts graft NNS cord-015365-iqdi99pd 914 2 were be VBD cord-015365-iqdi99pd 915 1 either either CC cord-015365-iqdi99pd 915 2 CD34þ CD34þ NNP cord-015365-iqdi99pd 915 3 selected select VBD cord-015365-iqdi99pd 915 4 and/or and/or CC cord-015365-iqdi99pd 915 5 CD3/19 cd3/19 NN cord-015365-iqdi99pd 915 6 depleted deplete VBD cord-015365-iqdi99pd 915 7 using use VBG cord-015365-iqdi99pd 915 8 the the DT cord-015365-iqdi99pd 915 9 Miltenyi Miltenyi NNP cord-015365-iqdi99pd 915 10 CliniMACS CliniMACS NNP cord-015365-iqdi99pd 915 11 device device NN cord-015365-iqdi99pd 915 12 . . . cord-015365-iqdi99pd 916 1 Median median JJ cord-015365-iqdi99pd 916 2 yield yield NN cord-015365-iqdi99pd 916 3 of of IN cord-015365-iqdi99pd 916 4 purified purify VBN cord-015365-iqdi99pd 916 5 CD34þ cd34þ NN cord-015365-iqdi99pd 916 6 cells cell NNS cord-015365-iqdi99pd 916 7 was be VBD cord-015365-iqdi99pd 916 8 10.17Â10 10.17â10 CD cord-015365-iqdi99pd 916 9 6 6 CD cord-015365-iqdi99pd 917 1 /kg /kg NFP cord-015365-iqdi99pd 917 2 ( ( -LRB- cord-015365-iqdi99pd 917 3 7.85 7.85 CD cord-015365-iqdi99pd 917 4 - - SYM cord-015365-iqdi99pd 917 5 24.3 24.3 CD cord-015365-iqdi99pd 917 6 ) ) -RRB- cord-015365-iqdi99pd 917 7 and and CC cord-015365-iqdi99pd 917 8 median median JJ cord-015365-iqdi99pd 917 9 CD3þ CD3þ NNP cord-015365-iqdi99pd 917 10 number number NN cord-015365-iqdi99pd 917 11 was be VBD cord-015365-iqdi99pd 917 12 5.5Â10 5.5â10 CD cord-015365-iqdi99pd 917 13 4 4 CD cord-015365-iqdi99pd 917 14 /kg /kg . cord-015365-iqdi99pd 917 15 ( ( -LRB- cord-015365-iqdi99pd 917 16 0.84 0.84 CD cord-015365-iqdi99pd 917 17 - - SYM cord-015365-iqdi99pd 917 18 10 10 CD cord-015365-iqdi99pd 917 19 ) ) -RRB- cord-015365-iqdi99pd 917 20 . . . cord-015365-iqdi99pd 918 1 All all DT cord-015365-iqdi99pd 918 2 patients patient NNS cord-015365-iqdi99pd 918 3 had have VBD cord-015365-iqdi99pd 918 4 WBC WBC NNP cord-015365-iqdi99pd 918 5 - - HYPH cord-015365-iqdi99pd 918 6 engraftment engraftment NNP cord-015365-iqdi99pd 918 7 on on IN cord-015365-iqdi99pd 918 8 median median JJ cord-015365-iqdi99pd 918 9 day day NN cord-015365-iqdi99pd 918 10 10 10 CD cord-015365-iqdi99pd 918 11 ( ( -LRB- cord-015365-iqdi99pd 918 12 8 8 CD cord-015365-iqdi99pd 918 13 - - SYM cord-015365-iqdi99pd 918 14 12 12 CD cord-015365-iqdi99pd 918 15 ) ) -RRB- cord-015365-iqdi99pd 918 16 . . . cord-015365-iqdi99pd 919 1 There there EX cord-015365-iqdi99pd 919 2 was be VBD cord-015365-iqdi99pd 919 3 no no DT cord-015365-iqdi99pd 919 4 GVHD GVHD NNP cord-015365-iqdi99pd 919 5 prophylaxis prophylaxis NN cord-015365-iqdi99pd 919 6 in in IN cord-015365-iqdi99pd 919 7 2 2 CD cord-015365-iqdi99pd 919 8 patients patient NNS cord-015365-iqdi99pd 919 9 and and CC cord-015365-iqdi99pd 919 10 either either CC cord-015365-iqdi99pd 919 11 cyclosporine cyclosporine NN cord-015365-iqdi99pd 919 12 - - HYPH cord-015365-iqdi99pd 919 13 A a NN cord-015365-iqdi99pd 919 14 or or CC cord-015365-iqdi99pd 919 15 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 919 16 mofetil mofetil NNP cord-015365-iqdi99pd 919 17 up up IN cord-015365-iqdi99pd 919 18 to to IN cord-015365-iqdi99pd 919 19 day day NN cord-015365-iqdi99pd 919 20 þ þ CD cord-015365-iqdi99pd 919 21 60 60 CD cord-015365-iqdi99pd 919 22 in in IN cord-015365-iqdi99pd 919 23 5 5 CD cord-015365-iqdi99pd 919 24 patients patient NNS cord-015365-iqdi99pd 919 25 . . . cord-015365-iqdi99pd 920 1 1 1 LS cord-015365-iqdi99pd 920 2 MUD MUD NNP cord-015365-iqdi99pd 920 3 - - HYPH cord-015365-iqdi99pd 920 4 HSCT HSCT NNP cord-015365-iqdi99pd 920 5 recipient recipient NN cord-015365-iqdi99pd 920 6 who who WP cord-015365-iqdi99pd 920 7 had have VBD cord-015365-iqdi99pd 920 8 6 6 CD cord-015365-iqdi99pd 920 9 IS be VBZ cord-015365-iqdi99pd 920 10 courses course NNS cord-015365-iqdi99pd 920 11 and and CC cord-015365-iqdi99pd 920 12 the the DT cord-015365-iqdi99pd 920 13 longest long JJS cord-015365-iqdi99pd 920 14 interval interval NN cord-015365-iqdi99pd 920 15 to to IN cord-015365-iqdi99pd 920 16 HSCT HSCT NNP cord-015365-iqdi99pd 920 17 ( ( -LRB- cord-015365-iqdi99pd 920 18 13 13 CD cord-015365-iqdi99pd 920 19 yrs yr NNS cord-015365-iqdi99pd 920 20 ) ) -RRB- cord-015365-iqdi99pd 920 21 and and CC cord-015365-iqdi99pd 920 22 who who WP cord-015365-iqdi99pd 920 23 received receive VBD cord-015365-iqdi99pd 920 24 the the DT cord-015365-iqdi99pd 920 25 highest high JJS cord-015365-iqdi99pd 920 26 CD cd NN cord-015365-iqdi99pd 920 27 3þ 3þ NNS cord-015365-iqdi99pd 920 28 dose dose NN cord-015365-iqdi99pd 920 29 ( ( -LRB- cord-015365-iqdi99pd 920 30 10Â10 10â10 CD cord-015365-iqdi99pd 920 31 4 4 CD cord-015365-iqdi99pd 920 32 /kg /kg NFP cord-015365-iqdi99pd 920 33 ) ) -RRB- cord-015365-iqdi99pd 920 34 developed develop VBD cord-015365-iqdi99pd 920 35 GVHD GVHD NNP cord-015365-iqdi99pd 920 36 ( ( -LRB- cord-015365-iqdi99pd 920 37 grade grade NN cord-015365-iqdi99pd 920 38 II II NNP cord-015365-iqdi99pd 920 39 ) ) -RRB- cord-015365-iqdi99pd 920 40 on on IN cord-015365-iqdi99pd 920 41 day day NN cord-015365-iqdi99pd 921 1 þ þ LS cord-015365-iqdi99pd 921 2 125 125 CD cord-015365-iqdi99pd 921 3 with with IN cord-015365-iqdi99pd 921 4 progressive progressive JJ cord-015365-iqdi99pd 921 5 kidney kidney NN cord-015365-iqdi99pd 921 6 failure failure NN cord-015365-iqdi99pd 921 7 due due JJ cord-015365-iqdi99pd 921 8 to to IN cord-015365-iqdi99pd 921 9 microangiopathic microangiopathic JJ cord-015365-iqdi99pd 921 10 hemolytic hemolytic JJ cord-015365-iqdi99pd 921 11 anemia anemia NN cord-015365-iqdi99pd 921 12 . . . cord-015365-iqdi99pd 922 1 All all DT cord-015365-iqdi99pd 922 2 children child NNS cord-015365-iqdi99pd 922 3 are be VBP cord-015365-iqdi99pd 922 4 alive alive JJ cord-015365-iqdi99pd 922 5 with with IN cord-015365-iqdi99pd 922 6 a a DT cord-015365-iqdi99pd 922 7 median median NN cord-015365-iqdi99pd 922 8 follow follow NN cord-015365-iqdi99pd 922 9 up up IN cord-015365-iqdi99pd 922 10 of of IN cord-015365-iqdi99pd 922 11 20 20 CD cord-015365-iqdi99pd 922 12 months month NNS cord-015365-iqdi99pd 922 13 ( ( -LRB- cord-015365-iqdi99pd 922 14 8 8 CD cord-015365-iqdi99pd 922 15 - - SYM cord-015365-iqdi99pd 922 16 149 149 CD cord-015365-iqdi99pd 922 17 ) ) -RRB- cord-015365-iqdi99pd 922 18 with with IN cord-015365-iqdi99pd 922 19 stable stable JJ cord-015365-iqdi99pd 922 20 complete complete JJ cord-015365-iqdi99pd 922 21 engraftment engraftment NN cord-015365-iqdi99pd 922 22 and and CC cord-015365-iqdi99pd 922 23 stable stable JJ cord-015365-iqdi99pd 922 24 chimerism chimerism NN cord-015365-iqdi99pd 922 25 of of IN cord-015365-iqdi99pd 922 26 median median NN cord-015365-iqdi99pd 922 27 98.5 98.5 CD cord-015365-iqdi99pd 922 28 % % NN cord-015365-iqdi99pd 922 29 ( ( -LRB- cord-015365-iqdi99pd 922 30 90.65 90.65 CD cord-015365-iqdi99pd 922 31 - - SYM cord-015365-iqdi99pd 922 32 100 100 CD cord-015365-iqdi99pd 922 33 ) ) -RRB- cord-015365-iqdi99pd 922 34 . . . cord-015365-iqdi99pd 923 1 Conclusions conclusion NNS cord-015365-iqdi99pd 923 2 . . . cord-015365-iqdi99pd 924 1 Long long JJ cord-015365-iqdi99pd 924 2 interval interval NN cord-015365-iqdi99pd 924 3 to to IN cord-015365-iqdi99pd 924 4 transplant transplant NN cord-015365-iqdi99pd 924 5 , , , cord-015365-iqdi99pd 924 6 multiple multiple JJ cord-015365-iqdi99pd 924 7 transfusions transfusion NNS cord-015365-iqdi99pd 924 8 and and CC cord-015365-iqdi99pd 924 9 long long JJ cord-015365-iqdi99pd 924 10 term term NN cord-015365-iqdi99pd 924 11 immunosuppression immunosuppression NN cord-015365-iqdi99pd 924 12 before before IN cord-015365-iqdi99pd 924 13 SCT SCT NNP cord-015365-iqdi99pd 924 14 are be VBP cord-015365-iqdi99pd 924 15 associated associate VBN cord-015365-iqdi99pd 924 16 with with IN cord-015365-iqdi99pd 924 17 poor poor JJ cord-015365-iqdi99pd 924 18 alternative alternative JJ cord-015365-iqdi99pd 924 19 donor donor NN cord-015365-iqdi99pd 924 20 SCT SCT NNP cord-015365-iqdi99pd 924 21 - - : cord-015365-iqdi99pd 924 22 outcomes outcome NNS cord-015365-iqdi99pd 924 23 in in IN cord-015365-iqdi99pd 924 24 SAA SAA NNP cord-015365-iqdi99pd 924 25 . . . cord-015365-iqdi99pd 925 1 Cyclophosphamide cyclophosphamide NN cord-015365-iqdi99pd 925 2 conditioning conditioning NN cord-015365-iqdi99pd 925 3 including include VBG cord-015365-iqdi99pd 925 4 FLU flu NN cord-015365-iqdi99pd 925 5 , , , cord-015365-iqdi99pd 925 6 THT THT NNP cord-015365-iqdi99pd 925 7 and and CC cord-015365-iqdi99pd 925 8 ATG ATG NNP cord-015365-iqdi99pd 925 9 but but CC cord-015365-iqdi99pd 925 10 without without IN cord-015365-iqdi99pd 925 11 TLI TLI NNP cord-015365-iqdi99pd 925 12 , , , cord-015365-iqdi99pd 925 13 high high JJ cord-015365-iqdi99pd 925 14 doses dose NNS cord-015365-iqdi99pd 925 15 of of IN cord-015365-iqdi99pd 925 16 purified purify VBN cord-015365-iqdi99pd 925 17 CD34þ cd34þ NN cord-015365-iqdi99pd 925 18 cells cell NNS cord-015365-iqdi99pd 925 19 and/or and/or CC cord-015365-iqdi99pd 925 20 CD3/19 cd3/19 NN cord-015365-iqdi99pd 925 21 depletion depletion NN cord-015365-iqdi99pd 925 22 may may MD cord-015365-iqdi99pd 925 23 prevent prevent VB cord-015365-iqdi99pd 925 24 graft graft NN cord-015365-iqdi99pd 925 25 rejection rejection NN cord-015365-iqdi99pd 925 26 and and CC cord-015365-iqdi99pd 925 27 GVHD GVHD NNP cord-015365-iqdi99pd 925 28 and and CC cord-015365-iqdi99pd 925 29 hasten hasten VB cord-015365-iqdi99pd 925 30 engraftment engraftment NN cord-015365-iqdi99pd 925 31 . . . cord-015365-iqdi99pd 926 1 This this DT cord-015365-iqdi99pd 926 2 may may MD cord-015365-iqdi99pd 926 3 facilitate facilitate VB cord-015365-iqdi99pd 926 4 the the DT cord-015365-iqdi99pd 926 5 decision decision NN cord-015365-iqdi99pd 926 6 for for IN cord-015365-iqdi99pd 926 7 the the DT cord-015365-iqdi99pd 926 8 earlier early JJR cord-015365-iqdi99pd 926 9 use use NN cord-015365-iqdi99pd 926 10 of of IN cord-015365-iqdi99pd 926 11 unrelated unrelated JJ cord-015365-iqdi99pd 926 12 stem stem NN cord-015365-iqdi99pd 926 13 cells cell NNS cord-015365-iqdi99pd 926 14 preventing prevent VBG cord-015365-iqdi99pd 926 15 complications complication NNS cord-015365-iqdi99pd 926 16 from from IN cord-015365-iqdi99pd 926 17 prolonged prolonged JJ cord-015365-iqdi99pd 926 18 and and CC cord-015365-iqdi99pd 926 19 multiple multiple JJ cord-015365-iqdi99pd 926 20 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 926 21 therapies therapy NNS cord-015365-iqdi99pd 926 22 and and CC cord-015365-iqdi99pd 926 23 presumably presumably RB cord-015365-iqdi99pd 926 24 increasing increase VBG cord-015365-iqdi99pd 926 25 the the DT cord-015365-iqdi99pd 926 26 survival survival NN cord-015365-iqdi99pd 926 27 of of IN cord-015365-iqdi99pd 926 28 patients patient NNS cord-015365-iqdi99pd 926 29 with with IN cord-015365-iqdi99pd 926 30 SAA SAA NNP cord-015365-iqdi99pd 926 31 without without IN cord-015365-iqdi99pd 926 32 a a DT cord-015365-iqdi99pd 926 33 matched match VBN cord-015365-iqdi99pd 926 34 sibling sibling NN cord-015365-iqdi99pd 926 35 donor donor NN cord-015365-iqdi99pd 926 36 . . . cord-015365-iqdi99pd 927 1 Extracorporeal extracorporeal JJ cord-015365-iqdi99pd 927 2 photopheresis photopheresis NN cord-015365-iqdi99pd 927 3 in in IN cord-015365-iqdi99pd 927 4 patients patient NNS cord-015365-iqdi99pd 927 5 with with IN cord-015365-iqdi99pd 927 6 high high JJ cord-015365-iqdi99pd 927 7 bleeding bleeding NN cord-015365-iqdi99pd 927 8 risks risk NNS cord-015365-iqdi99pd 927 9 Background background NN cord-015365-iqdi99pd 927 10 . . . cord-015365-iqdi99pd 928 1 For for IN cord-015365-iqdi99pd 928 2 anticoagulation anticoagulation NN cord-015365-iqdi99pd 928 3 in in IN cord-015365-iqdi99pd 928 4 extracorporeal extracorporeal JJ cord-015365-iqdi99pd 928 5 photopheresis photopheresis NN cord-015365-iqdi99pd 928 6 ( ( -LRB- cord-015365-iqdi99pd 928 7 ECP ECP NNP cord-015365-iqdi99pd 928 8 ) ) -RRB- cord-015365-iqdi99pd 928 9 to to TO cord-015365-iqdi99pd 928 10 prevent prevent VB cord-015365-iqdi99pd 928 11 clotting clotting NN cord-015365-iqdi99pd 928 12 in in IN cord-015365-iqdi99pd 928 13 the the DT cord-015365-iqdi99pd 928 14 extracorporeal extracorporeal JJ cord-015365-iqdi99pd 928 15 circuit circuit NN cord-015365-iqdi99pd 928 16 , , , cord-015365-iqdi99pd 928 17 the the DT cord-015365-iqdi99pd 928 18 manufacturer manufacturer NN cord-015365-iqdi99pd 928 19 's 's POS cord-015365-iqdi99pd 928 20 recommendation recommendation NN cord-015365-iqdi99pd 928 21 is be VBZ cord-015365-iqdi99pd 928 22 the the DT cord-015365-iqdi99pd 928 23 use use NN cord-015365-iqdi99pd 928 24 of of IN cord-015365-iqdi99pd 928 25 heparin heparin NN cord-015365-iqdi99pd 928 26 ( ( -LRB- cord-015365-iqdi99pd 928 27 normally normally RB cord-015365-iqdi99pd 928 28 10,000 10,000 CD cord-015365-iqdi99pd 928 29 Units unit NNS cord-015365-iqdi99pd 928 30 ) ) -RRB- cord-015365-iqdi99pd 928 31 . . . cord-015365-iqdi99pd 929 1 However however RB cord-015365-iqdi99pd 929 2 , , , cord-015365-iqdi99pd 929 3 patients patient NNS cord-015365-iqdi99pd 929 4 with with IN cord-015365-iqdi99pd 929 5 acute acute JJ cord-015365-iqdi99pd 929 6 graft graft NN cord-015365-iqdi99pd 929 7 - - HYPH cord-015365-iqdi99pd 929 8 versushost versushost NN cord-015365-iqdi99pd 929 9 disease disease NN cord-015365-iqdi99pd 929 10 ( ( -LRB- cord-015365-iqdi99pd 929 11 aGvHD agvhd NN cord-015365-iqdi99pd 929 12 ) ) -RRB- cord-015365-iqdi99pd 929 13 after after IN cord-015365-iqdi99pd 929 14 allogeneic allogeneic JJ cord-015365-iqdi99pd 929 15 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 929 16 stem stem NN cord-015365-iqdi99pd 929 17 cell cell NN cord-015365-iqdi99pd 929 18 transplantation transplantation NN cord-015365-iqdi99pd 929 19 are be VBP cord-015365-iqdi99pd 929 20 at at IN cord-015365-iqdi99pd 929 21 high high JJ cord-015365-iqdi99pd 929 22 risk risk NN cord-015365-iqdi99pd 929 23 for for IN cord-015365-iqdi99pd 929 24 bleeding bleed VBG cord-015365-iqdi99pd 929 25 complications complication NNS cord-015365-iqdi99pd 929 26 due due JJ cord-015365-iqdi99pd 929 27 to to IN cord-015365-iqdi99pd 929 28 low low JJ cord-015365-iqdi99pd 929 29 platelet platelet NN cord-015365-iqdi99pd 929 30 counts count NNS cord-015365-iqdi99pd 929 31 , , , cord-015365-iqdi99pd 929 32 intestinal intestinal JJ cord-015365-iqdi99pd 929 33 lesions lesion NNS cord-015365-iqdi99pd 929 34 from from IN cord-015365-iqdi99pd 929 35 aGvHD agvhd NN cord-015365-iqdi99pd 929 36 or or CC cord-015365-iqdi99pd 929 37 impaired impair VBN cord-015365-iqdi99pd 929 38 hepatic hepatic JJ cord-015365-iqdi99pd 929 39 function function NN cord-015365-iqdi99pd 929 40 . . . cord-015365-iqdi99pd 930 1 For for IN cord-015365-iqdi99pd 930 2 these these DT cord-015365-iqdi99pd 930 3 patients patient NNS cord-015365-iqdi99pd 930 4 , , , cord-015365-iqdi99pd 930 5 alternative alternative JJ cord-015365-iqdi99pd 930 6 anticoagulation anticoagulation NN cord-015365-iqdi99pd 930 7 using use VBG cord-015365-iqdi99pd 930 8 acid acid NN cord-015365-iqdi99pd 930 9 citrate citrate NN cord-015365-iqdi99pd 930 10 dextrose dextrose NN cord-015365-iqdi99pd 930 11 ( ( -LRB- cord-015365-iqdi99pd 930 12 ACD ACD NNP cord-015365-iqdi99pd 930 13 - - HYPH cord-015365-iqdi99pd 930 14 A a NN cord-015365-iqdi99pd 930 15 ) ) -RRB- cord-015365-iqdi99pd 930 16 has have VBZ cord-015365-iqdi99pd 930 17 been be VBN cord-015365-iqdi99pd 930 18 infrequently infrequently RB cord-015365-iqdi99pd 930 19 used use VBN cord-015365-iqdi99pd 930 20 in in IN cord-015365-iqdi99pd 930 21 small small JJ cord-015365-iqdi99pd 930 22 patient patient JJ cord-015365-iqdi99pd 930 23 cohorts cohort NNS cord-015365-iqdi99pd 930 24 . . . cord-015365-iqdi99pd 931 1 Methods method NNS cord-015365-iqdi99pd 931 2 . . . cord-015365-iqdi99pd 932 1 We -PRON- PRP cord-015365-iqdi99pd 932 2 investigated investigate VBD cord-015365-iqdi99pd 932 3 the the DT cord-015365-iqdi99pd 932 4 safety safety NN cord-015365-iqdi99pd 932 5 and and CC cord-015365-iqdi99pd 932 6 efficacy efficacy NN cord-015365-iqdi99pd 932 7 of of IN cord-015365-iqdi99pd 932 8 this this DT cord-015365-iqdi99pd 932 9 approach approach NN cord-015365-iqdi99pd 932 10 in in IN cord-015365-iqdi99pd 932 11 94 94 CD cord-015365-iqdi99pd 932 12 consecutive consecutive JJ cord-015365-iqdi99pd 932 13 patients patient NNS cord-015365-iqdi99pd 932 14 ( ( -LRB- cord-015365-iqdi99pd 932 15 43 43 CD cord-015365-iqdi99pd 932 16 male male NN cord-015365-iqdi99pd 932 17 , , , cord-015365-iqdi99pd 932 18 51 51 CD cord-015365-iqdi99pd 932 19 female female NN cord-015365-iqdi99pd 932 20 ) ) -RRB- cord-015365-iqdi99pd 932 21 with with IN cord-015365-iqdi99pd 932 22 aGvHD agvhd NN cord-015365-iqdi99pd 932 23 ( ( -LRB- cord-015365-iqdi99pd 932 24 45 45 CD cord-015365-iqdi99pd 932 25 % % NN cord-015365-iqdi99pd 932 26 with with IN cord-015365-iqdi99pd 932 27 gut gut NN cord-015365-iqdi99pd 932 28 GvHD GvHD NNP cord-015365-iqdi99pd 932 29 ) ) -RRB- cord-015365-iqdi99pd 932 30 undergoing undergo VBG cord-015365-iqdi99pd 932 31 ECP ECP NNP cord-015365-iqdi99pd 932 32 with with IN cord-015365-iqdi99pd 932 33 ACD ACD NNP cord-015365-iqdi99pd 932 34 - - HYPH cord-015365-iqdi99pd 932 35 A a DT cord-015365-iqdi99pd 932 36 anticoagulation anticoagulation NN cord-015365-iqdi99pd 932 37 at at IN cord-015365-iqdi99pd 932 38 a a DT cord-015365-iqdi99pd 932 39 single single JJ cord-015365-iqdi99pd 932 40 institution institution NN cord-015365-iqdi99pd 932 41 2 2 CD cord-015365-iqdi99pd 932 42 to to TO cord-015365-iqdi99pd 932 43 3 3 CD cord-015365-iqdi99pd 932 44 times time NNS cord-015365-iqdi99pd 932 45 per per IN cord-015365-iqdi99pd 932 46 week week NN cord-015365-iqdi99pd 932 47 on on IN cord-015365-iqdi99pd 932 48 a a DT cord-015365-iqdi99pd 932 49 weekly weekly JJ cord-015365-iqdi99pd 932 50 basis basis NN cord-015365-iqdi99pd 932 51 until until IN cord-015365-iqdi99pd 932 52 complete complete JJ cord-015365-iqdi99pd 932 53 resolution resolution NN cord-015365-iqdi99pd 932 54 of of IN cord-015365-iqdi99pd 932 55 aGvHD agvhd NN cord-015365-iqdi99pd 932 56 . . . cord-015365-iqdi99pd 933 1 A a DT cord-015365-iqdi99pd 933 2 total total NN cord-015365-iqdi99pd 933 3 of of IN cord-015365-iqdi99pd 933 4 1242 1242 CD cord-015365-iqdi99pd 933 5 ECP ECP NNP cord-015365-iqdi99pd 933 6 procedures procedure NNS cord-015365-iqdi99pd 933 7 were be VBD cord-015365-iqdi99pd 933 8 analyzed analyze VBN cord-015365-iqdi99pd 933 9 with with IN cord-015365-iqdi99pd 933 10 respect respect NN cord-015365-iqdi99pd 933 11 to to IN cord-015365-iqdi99pd 933 12 side side JJ cord-015365-iqdi99pd 933 13 effects effect NNS cord-015365-iqdi99pd 933 14 and and CC cord-015365-iqdi99pd 933 15 changes change NNS cord-015365-iqdi99pd 933 16 in in IN cord-015365-iqdi99pd 933 17 haemoglobin haemoglobin NN cord-015365-iqdi99pd 933 18 and and CC cord-015365-iqdi99pd 933 19 platelet platelet NN cord-015365-iqdi99pd 933 20 levels level NNS cord-015365-iqdi99pd 933 21 . . . cord-015365-iqdi99pd 934 1 Moreover moreover RB cord-015365-iqdi99pd 934 2 , , , cord-015365-iqdi99pd 934 3 in in IN cord-015365-iqdi99pd 934 4 a a DT cord-015365-iqdi99pd 934 5 proportion proportion NN cord-015365-iqdi99pd 934 6 of of IN cord-015365-iqdi99pd 934 7 ECP ECP NNP cord-015365-iqdi99pd 934 8 treatments treatment NNS cord-015365-iqdi99pd 934 9 activated activate VBD cord-015365-iqdi99pd 934 10 partial partial JJ cord-015365-iqdi99pd 934 11 thromboplastin thromboplastin NNP cord-015365-iqdi99pd 934 12 time time NN cord-015365-iqdi99pd 934 13 ( ( -LRB- cord-015365-iqdi99pd 934 14 aPTT aptt NN cord-015365-iqdi99pd 934 15 ) ) -RRB- cord-015365-iqdi99pd 934 16 was be VBD cord-015365-iqdi99pd 934 17 monitored monitor VBN cord-015365-iqdi99pd 934 18 . . . cord-015365-iqdi99pd 935 1 Priming prime VBG cord-015365-iqdi99pd 935 2 of of IN cord-015365-iqdi99pd 935 3 the the DT cord-015365-iqdi99pd 935 4 separator separator NN cord-015365-iqdi99pd 935 5 was be VBD cord-015365-iqdi99pd 935 6 performed perform VBN cord-015365-iqdi99pd 935 7 with with IN cord-015365-iqdi99pd 935 8 1,000 1,000 CD cord-015365-iqdi99pd 935 9 Units unit NNS cord-015365-iqdi99pd 935 10 of of IN cord-015365-iqdi99pd 935 11 heparin heparin NN cord-015365-iqdi99pd 935 12 followed follow VBN cord-015365-iqdi99pd 935 13 by by IN cord-015365-iqdi99pd 935 14 anticoagulation anticoagulation NN cord-015365-iqdi99pd 935 15 with with IN cord-015365-iqdi99pd 935 16 ACD ACD NNP cord-015365-iqdi99pd 935 17 - - HYPH cord-015365-iqdi99pd 935 18 A a NN cord-015365-iqdi99pd 935 19 at at IN cord-015365-iqdi99pd 935 20 a a DT cord-015365-iqdi99pd 935 21 ratio ratio NN cord-015365-iqdi99pd 935 22 of of IN cord-015365-iqdi99pd 935 23 1:10 1:10 CD cord-015365-iqdi99pd 935 24 during during IN cord-015365-iqdi99pd 935 25 the the DT cord-015365-iqdi99pd 935 26 procedure procedure NN cord-015365-iqdi99pd 935 27 . . . cord-015365-iqdi99pd 936 1 Results result NNS cord-015365-iqdi99pd 936 2 . . . cord-015365-iqdi99pd 937 1 ECP ECP NNP cord-015365-iqdi99pd 937 2 was be VBD cord-015365-iqdi99pd 937 3 tolerated tolerate VBN cord-015365-iqdi99pd 937 4 well well RB cord-015365-iqdi99pd 937 5 by by IN cord-015365-iqdi99pd 937 6 all all DT cord-015365-iqdi99pd 937 7 patients patient NNS cord-015365-iqdi99pd 937 8 . . . cord-015365-iqdi99pd 938 1 In in IN cord-015365-iqdi99pd 938 2 only only RB cord-015365-iqdi99pd 938 3 0.2 0.2 CD cord-015365-iqdi99pd 938 4 % % NN cord-015365-iqdi99pd 938 5 of of IN cord-015365-iqdi99pd 938 6 procedures procedure NNS cord-015365-iqdi99pd 938 7 mild mild JJ cord-015365-iqdi99pd 938 8 citrate citrate NN cord-015365-iqdi99pd 938 9 reactions reaction NNS cord-015365-iqdi99pd 938 10 seen see VBN cord-015365-iqdi99pd 938 11 as as IN cord-015365-iqdi99pd 938 12 transient transient JJ cord-015365-iqdi99pd 938 13 paresthesias paresthesia NNS cord-015365-iqdi99pd 938 14 were be VBD cord-015365-iqdi99pd 938 15 observed observe VBN cord-015365-iqdi99pd 938 16 but but CC cord-015365-iqdi99pd 938 17 resolved resolve VBN cord-015365-iqdi99pd 938 18 without without IN cord-015365-iqdi99pd 938 19 the the DT cord-015365-iqdi99pd 938 20 need need NN cord-015365-iqdi99pd 938 21 for for IN cord-015365-iqdi99pd 938 22 calcium calcium NN cord-015365-iqdi99pd 938 23 substitution substitution NN cord-015365-iqdi99pd 938 24 . . . cord-015365-iqdi99pd 939 1 In in IN cord-015365-iqdi99pd 939 2 no no DT cord-015365-iqdi99pd 939 3 case case NN cord-015365-iqdi99pd 939 4 bleeding bleed VBG cord-015365-iqdi99pd 939 5 complications complication NNS cord-015365-iqdi99pd 939 6 were be VBD cord-015365-iqdi99pd 939 7 noted note VBN cord-015365-iqdi99pd 939 8 during during IN cord-015365-iqdi99pd 939 9 or or CC cord-015365-iqdi99pd 939 10 after after IN cord-015365-iqdi99pd 939 11 citrate citrate NN cord-015365-iqdi99pd 939 12 anticoagulation anticoagulation NN cord-015365-iqdi99pd 939 13 . . . cord-015365-iqdi99pd 940 1 During during IN cord-015365-iqdi99pd 940 2 ECP ECP NNP cord-015365-iqdi99pd 940 3 , , , cord-015365-iqdi99pd 940 4 aPTT aptt CD cord-015365-iqdi99pd 940 5 levels level NNS cord-015365-iqdi99pd 940 6 increased increase VBD cord-015365-iqdi99pd 940 7 marginally marginally RB cord-015365-iqdi99pd 940 8 from from IN cord-015365-iqdi99pd 940 9 a a DT cord-015365-iqdi99pd 940 10 median median NN cord-015365-iqdi99pd 940 11 of of IN cord-015365-iqdi99pd 940 12 32.1 32.1 CD cord-015365-iqdi99pd 940 13 sec sec NNP cord-015365-iqdi99pd 940 14 . . . cord-015365-iqdi99pd 941 1 ( ( -LRB- cord-015365-iqdi99pd 941 2 range range NN cord-015365-iqdi99pd 941 3 , , , cord-015365-iqdi99pd 941 4 25.3 25.3 CD cord-015365-iqdi99pd 941 5 to to IN cord-015365-iqdi99pd 941 6 44.5 44.5 CD cord-015365-iqdi99pd 941 7 sec sec NNP cord-015365-iqdi99pd 941 8 ) ) -RRB- cord-015365-iqdi99pd 941 9 before before IN cord-015365-iqdi99pd 941 10 to to IN cord-015365-iqdi99pd 941 11 a a DT cord-015365-iqdi99pd 941 12 medium medium NN cord-015365-iqdi99pd 941 13 of of IN cord-015365-iqdi99pd 941 14 35.4 35.4 CD cord-015365-iqdi99pd 941 15 sec sec NNP cord-015365-iqdi99pd 941 16 . . . cord-015365-iqdi99pd 942 1 ( ( -LRB- cord-015365-iqdi99pd 942 2 range range NN cord-015365-iqdi99pd 942 3 , , , cord-015365-iqdi99pd 942 4 25.4 25.4 CD cord-015365-iqdi99pd 942 5 to to IN cord-015365-iqdi99pd 942 6 54.7 54.7 CD cord-015365-iqdi99pd 942 7 sec sec NNP cord-015365-iqdi99pd 942 8 . . . cord-015365-iqdi99pd 942 9 ) ) -RRB- cord-015365-iqdi99pd 943 1 after after IN cord-015365-iqdi99pd 943 2 ECP ECP NNP cord-015365-iqdi99pd 943 3 , , , cord-015365-iqdi99pd 943 4 respectively respectively RB cord-015365-iqdi99pd 943 5 . . . cord-015365-iqdi99pd 944 1 At at IN cord-015365-iqdi99pd 944 2 start start NN cord-015365-iqdi99pd 944 3 of of IN cord-015365-iqdi99pd 944 4 ECP ECP NNP cord-015365-iqdi99pd 944 5 51 51 CD cord-015365-iqdi99pd 944 6 % % NN cord-015365-iqdi99pd 944 7 of of IN cord-015365-iqdi99pd 944 8 patients patient NNS cord-015365-iqdi99pd 944 9 had have VBD cord-015365-iqdi99pd 944 10 platelet platelet NN cord-015365-iqdi99pd 944 11 counts count NNS cord-015365-iqdi99pd 945 1 < < XX cord-015365-iqdi99pd 945 2 100 100 CD cord-015365-iqdi99pd 945 3 G G NNP cord-015365-iqdi99pd 945 4 / / SYM cord-015365-iqdi99pd 945 5 l l NN cord-015365-iqdi99pd 945 6 and and CC cord-015365-iqdi99pd 945 7 26 26 CD cord-015365-iqdi99pd 945 8 % % NN cord-015365-iqdi99pd 945 9 < < XX cord-015365-iqdi99pd 945 10 50 50 CD cord-015365-iqdi99pd 945 11 G g NN cord-015365-iqdi99pd 945 12 / / SYM cord-015365-iqdi99pd 945 13 L l NN cord-015365-iqdi99pd 945 14 , , , cord-015365-iqdi99pd 945 15 respectively respectively RB cord-015365-iqdi99pd 945 16 . . . cord-015365-iqdi99pd 946 1 Haemoglobin haemoglobin NN cord-015365-iqdi99pd 946 2 and and CC cord-015365-iqdi99pd 946 3 platelet platelet NN cord-015365-iqdi99pd 946 4 counts count NNS cord-015365-iqdi99pd 946 5 decreased decrease VBD cord-015365-iqdi99pd 946 6 by by IN cord-015365-iqdi99pd 946 7 11 11 CD cord-015365-iqdi99pd 946 8 % % NN cord-015365-iqdi99pd 946 9 and and CC cord-015365-iqdi99pd 946 10 14 14 CD cord-015365-iqdi99pd 946 11 % % NN cord-015365-iqdi99pd 946 12 , , , cord-015365-iqdi99pd 946 13 respectively respectively RB cord-015365-iqdi99pd 946 14 . . . cord-015365-iqdi99pd 947 1 Conclusions conclusion NNS cord-015365-iqdi99pd 947 2 . . . cord-015365-iqdi99pd 948 1 In in IN cord-015365-iqdi99pd 948 2 conclusion conclusion NN cord-015365-iqdi99pd 948 3 , , , cord-015365-iqdi99pd 948 4 citrate citrate NN cord-015365-iqdi99pd 948 5 anticoagulation anticoagulation NN cord-015365-iqdi99pd 948 6 during during IN cord-015365-iqdi99pd 948 7 ECP ECP NNP cord-015365-iqdi99pd 948 8 is be VBZ cord-015365-iqdi99pd 948 9 a a DT cord-015365-iqdi99pd 948 10 feasible feasible JJ cord-015365-iqdi99pd 948 11 and and CC cord-015365-iqdi99pd 948 12 safe safe JJ cord-015365-iqdi99pd 948 13 alternative alternative NN cord-015365-iqdi99pd 948 14 for for IN cord-015365-iqdi99pd 948 15 patients patient NNS cord-015365-iqdi99pd 948 16 with with IN cord-015365-iqdi99pd 948 17 high high JJ cord-015365-iqdi99pd 948 18 risk risk NN cord-015365-iqdi99pd 948 19 for for IN cord-015365-iqdi99pd 948 20 bleeding bleed VBG cord-015365-iqdi99pd 948 21 complications complication NNS cord-015365-iqdi99pd 948 22 , , , cord-015365-iqdi99pd 948 23 especially especially RB cord-015365-iqdi99pd 948 24 for for IN cord-015365-iqdi99pd 948 25 those those DT cord-015365-iqdi99pd 948 26 after after IN cord-015365-iqdi99pd 948 27 allogeneic allogeneic JJ cord-015365-iqdi99pd 948 28 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 948 29 stem stem NN cord-015365-iqdi99pd 948 30 cell cell NN cord-015365-iqdi99pd 948 31 transplantation transplantation NN cord-015365-iqdi99pd 948 32 . . . cord-015365-iqdi99pd 949 1 Allogeneic allogeneic IN cord-015365-iqdi99pd 949 2 stem stem VBP cord-015365-iqdi99pd 949 3 cell cell NN cord-015365-iqdi99pd 949 4 transplantation transplantation NN cord-015365-iqdi99pd 949 5 with with IN cord-015365-iqdi99pd 949 6 reduced reduce VBN cord-015365-iqdi99pd 949 7 intensity intensity NN cord-015365-iqdi99pd 949 8 conditioning conditioning NN cord-015365-iqdi99pd 949 9 in in IN cord-015365-iqdi99pd 949 10 patients patient NNS cord-015365-iqdi99pd 949 11 with with IN cord-015365-iqdi99pd 949 12 therapy therapy NN cord-015365-iqdi99pd 949 13 - - HYPH cord-015365-iqdi99pd 949 14 related relate VBN cord-015365-iqdi99pd 949 15 myeloid myeloid JJ cord-015365-iqdi99pd 949 16 neoplasms neoplasm NNS cord-015365-iqdi99pd 949 17 Background Background NNP cord-015365-iqdi99pd 949 18 . . . cord-015365-iqdi99pd 950 1 Therapy therapy NN cord-015365-iqdi99pd 950 2 - - HYPH cord-015365-iqdi99pd 950 3 related relate VBN cord-015365-iqdi99pd 950 4 myeloid myeloid JJ cord-015365-iqdi99pd 950 5 neoplasms neoplasm NNS cord-015365-iqdi99pd 950 6 ( ( -LRB- cord-015365-iqdi99pd 950 7 t t NNP cord-015365-iqdi99pd 950 8 - - HYPH cord-015365-iqdi99pd 950 9 MNs MNs NNP cord-015365-iqdi99pd 950 10 ) ) -RRB- cord-015365-iqdi99pd 950 11 occur occur VBP cord-015365-iqdi99pd 950 12 as as IN cord-015365-iqdi99pd 950 13 late late JJ cord-015365-iqdi99pd 950 14 complication complication NN cord-015365-iqdi99pd 950 15 after after IN cord-015365-iqdi99pd 950 16 cytotoxic cytotoxic JJ cord-015365-iqdi99pd 950 17 therapy therapy NN cord-015365-iqdi99pd 950 18 for for IN cord-015365-iqdi99pd 950 19 malignant malignant JJ cord-015365-iqdi99pd 950 20 and and CC cord-015365-iqdi99pd 950 21 non non JJ cord-015365-iqdi99pd 950 22 - - JJ cord-015365-iqdi99pd 950 23 malignant malignant JJ cord-015365-iqdi99pd 950 24 disorders disorder NNS cord-015365-iqdi99pd 950 25 . . . cord-015365-iqdi99pd 951 1 In in IN cord-015365-iqdi99pd 951 2 most most JJS cord-015365-iqdi99pd 951 3 patients patient NNS cord-015365-iqdi99pd 951 4 with with IN cord-015365-iqdi99pd 951 5 t t NNP cord-015365-iqdi99pd 951 6 - - HYPH cord-015365-iqdi99pd 951 7 MNs MNs NNP cord-015365-iqdi99pd 951 8 , , , cord-015365-iqdi99pd 951 9 allogeneic allogeneic IN cord-015365-iqdi99pd 951 10 haematopoietic haematopoietic JJ cord-015365-iqdi99pd 951 11 stem stem NN cord-015365-iqdi99pd 951 12 cell cell NN cord-015365-iqdi99pd 951 13 transplantation transplantation NN cord-015365-iqdi99pd 951 14 ( ( -LRB- cord-015365-iqdi99pd 951 15 HSCT HSCT NNP cord-015365-iqdi99pd 951 16 ) ) -RRB- cord-015365-iqdi99pd 951 17 is be VBZ cord-015365-iqdi99pd 951 18 the the DT cord-015365-iqdi99pd 951 19 only only JJ cord-015365-iqdi99pd 951 20 potentially potentially RB cord-015365-iqdi99pd 951 21 curative curative JJ cord-015365-iqdi99pd 951 22 approach approach NN cord-015365-iqdi99pd 951 23 . . . cord-015365-iqdi99pd 952 1 Performed perform VBN cord-015365-iqdi99pd 952 2 with with IN cord-015365-iqdi99pd 952 3 myeloablative myeloablative JJ cord-015365-iqdi99pd 952 4 conditioning conditioning NN cord-015365-iqdi99pd 952 5 this this DT cord-015365-iqdi99pd 952 6 option option NN cord-015365-iqdi99pd 952 7 is be VBZ cord-015365-iqdi99pd 952 8 associated associate VBN cord-015365-iqdi99pd 952 9 with with IN cord-015365-iqdi99pd 952 10 a a DT cord-015365-iqdi99pd 952 11 high high JJ cord-015365-iqdi99pd 952 12 transplantrelated transplantrelate VBN cord-015365-iqdi99pd 952 13 mortality mortality NN cord-015365-iqdi99pd 952 14 ( ( -LRB- cord-015365-iqdi99pd 952 15 TRM TRM NNP cord-015365-iqdi99pd 952 16 ) ) -RRB- cord-015365-iqdi99pd 952 17 . . . cord-015365-iqdi99pd 953 1 Here here RB cord-015365-iqdi99pd 953 2 we -PRON- PRP cord-015365-iqdi99pd 953 3 report report VBP cord-015365-iqdi99pd 953 4 our -PRON- PRP$ cord-015365-iqdi99pd 953 5 results result NNS cord-015365-iqdi99pd 953 6 in in IN cord-015365-iqdi99pd 953 7 using use VBG cord-015365-iqdi99pd 953 8 reduced reduce VBN cord-015365-iqdi99pd 953 9 intensity intensity NN cord-015365-iqdi99pd 953 10 conditioning conditioning NN cord-015365-iqdi99pd 953 11 ( ( -LRB- cord-015365-iqdi99pd 953 12 RIC RIC NNP cord-015365-iqdi99pd 953 13 ) ) -RRB- cord-015365-iqdi99pd 953 14 in in IN cord-015365-iqdi99pd 953 15 these these DT cord-015365-iqdi99pd 953 16 patients patient NNS cord-015365-iqdi99pd 953 17 . . . cord-015365-iqdi99pd 954 1 Methods method NNS cord-015365-iqdi99pd 954 2 . . . cord-015365-iqdi99pd 955 1 Between between IN cord-015365-iqdi99pd 955 2 July July NNP cord-015365-iqdi99pd 955 3 2000 2000 CD cord-015365-iqdi99pd 955 4 and and CC cord-015365-iqdi99pd 955 5 February February NNP cord-015365-iqdi99pd 955 6 2011 2011 CD cord-015365-iqdi99pd 955 7 , , , cord-015365-iqdi99pd 955 8 18 18 CD cord-015365-iqdi99pd 955 9 patients patient NNS cord-015365-iqdi99pd 955 10 ( ( -LRB- cord-015365-iqdi99pd 955 11 male male NN cord-015365-iqdi99pd 955 12 : : : cord-015365-iqdi99pd 955 13 5 5 CD cord-015365-iqdi99pd 955 14 ; ; , cord-015365-iqdi99pd 955 15 female female JJ cord-015365-iqdi99pd 955 16 : : : cord-015365-iqdi99pd 955 17 13 13 CD cord-015365-iqdi99pd 955 18 ; ; : cord-015365-iqdi99pd 955 19 median median JJ cord-015365-iqdi99pd 955 20 age age NN cord-015365-iqdi99pd 955 21 : : : cord-015365-iqdi99pd 955 22 48.5 48.5 CD cord-015365-iqdi99pd 955 23 years year NNS cord-015365-iqdi99pd 955 24 ; ; : cord-015365-iqdi99pd 955 25 range range NN cord-015365-iqdi99pd 955 26 : : : cord-015365-iqdi99pd 955 27 28 28 CD cord-015365-iqdi99pd 955 28 - - SYM cord-015365-iqdi99pd 955 29 66 66 CD cord-015365-iqdi99pd 955 30 ) ) -RRB- cord-015365-iqdi99pd 955 31 with with IN cord-015365-iqdi99pd 955 32 t t NNP cord-015365-iqdi99pd 955 33 - - HYPH cord-015365-iqdi99pd 955 34 MNs MNs NNP cord-015365-iqdi99pd 955 35 underwent undergo VBD cord-015365-iqdi99pd 955 36 RIC RIC NNP cord-015365-iqdi99pd 955 37 HSCT HSCT NNP cord-015365-iqdi99pd 955 38 either either CC cord-015365-iqdi99pd 955 39 from from IN cord-015365-iqdi99pd 955 40 a a DT cord-015365-iqdi99pd 955 41 matched match VBN cord-015365-iqdi99pd 955 42 sibling sibling NN cord-015365-iqdi99pd 955 43 ( ( -LRB- cord-015365-iqdi99pd 955 44 n n NNP cord-015365-iqdi99pd 955 45 ¼ ¼ NNP cord-015365-iqdi99pd 955 46 8) 8) NNP cord-015365-iqdi99pd 955 47 or or CC cord-015365-iqdi99pd 955 48 a a DT cord-015365-iqdi99pd 955 49 matched match VBN cord-015365-iqdi99pd 955 50 unrelated unrelated JJ cord-015365-iqdi99pd 955 51 ( ( -LRB- cord-015365-iqdi99pd 955 52 n n NN cord-015365-iqdi99pd 955 53 ¼ ¼ NNP cord-015365-iqdi99pd 955 54 7 7 CD cord-015365-iqdi99pd 955 55 ) ) -RRB- cord-015365-iqdi99pd 955 56 or or CC cord-015365-iqdi99pd 955 57 one one CD cord-015365-iqdi99pd 955 58 antigen antigen NN cord-015365-iqdi99pd 955 59 mismatched mismatch VBD cord-015365-iqdi99pd 955 60 unrelated unrelated JJ cord-015365-iqdi99pd 955 61 donor donor NN cord-015365-iqdi99pd 955 62 ( ( -LRB- cord-015365-iqdi99pd 955 63 n n NN cord-015365-iqdi99pd 955 64 ¼ ¼ NNP cord-015365-iqdi99pd 955 65 3 3 CD cord-015365-iqdi99pd 955 66 ) ) -RRB- cord-015365-iqdi99pd 955 67 . . . cord-015365-iqdi99pd 956 1 Primary primary JJ cord-015365-iqdi99pd 956 2 disorders disorder NNS cord-015365-iqdi99pd 956 3 were be VBD cord-015365-iqdi99pd 956 4 solid solid JJ cord-015365-iqdi99pd 956 5 tumors tumor NNS cord-015365-iqdi99pd 956 6 and and CC cord-015365-iqdi99pd 956 7 haematologic haematologic JJ cord-015365-iqdi99pd 956 8 malignancies malignancy NNS cord-015365-iqdi99pd 956 9 in in IN cord-015365-iqdi99pd 956 10 9 9 CD cord-015365-iqdi99pd 956 11 patients patient NNS cord-015365-iqdi99pd 956 12 each each DT cord-015365-iqdi99pd 956 13 . . . cord-015365-iqdi99pd 957 1 Patients patient NNS cord-015365-iqdi99pd 957 2 presented present VBN cord-015365-iqdi99pd 957 3 with with IN cord-015365-iqdi99pd 957 4 t t NN cord-015365-iqdi99pd 957 5 - - HYPH cord-015365-iqdi99pd 957 6 MDS MDS NNP cord-015365-iqdi99pd 957 7 ( ( -LRB- cord-015365-iqdi99pd 957 8 n n NN cord-015365-iqdi99pd 957 9 ¼ ¼ NNP cord-015365-iqdi99pd 957 10 4 4 CD cord-015365-iqdi99pd 957 11 ) ) -RRB- cord-015365-iqdi99pd 957 12 , , , cord-015365-iqdi99pd 957 13 t t NNP cord-015365-iqdi99pd 957 14 - - HYPH cord-015365-iqdi99pd 957 15 AML AML NNP cord-015365-iqdi99pd 957 16 ( ( -LRB- cord-015365-iqdi99pd 957 17 n n NNP cord-015365-iqdi99pd 957 18 ¼ ¼ NNP cord-015365-iqdi99pd 957 19 13 13 CD cord-015365-iqdi99pd 957 20 ) ) -RRB- cord-015365-iqdi99pd 957 21 and and CC cord-015365-iqdi99pd 957 22 t t NN cord-015365-iqdi99pd 957 23 - - HYPH cord-015365-iqdi99pd 957 24 MDS MDS NNP cord-015365-iqdi99pd 957 25 / / SYM cord-015365-iqdi99pd 957 26 MPN MPN NNP cord-015365-iqdi99pd 957 27 ( ( -LRB- cord-015365-iqdi99pd 957 28 n n NNP cord-015365-iqdi99pd 957 29 ¼ ¼ NNP cord-015365-iqdi99pd 957 30 1 1 CD cord-015365-iqdi99pd 957 31 ) ) -RRB- cord-015365-iqdi99pd 957 32 . . . cord-015365-iqdi99pd 958 1 Cytogenetic cytogenetic JJ cord-015365-iqdi99pd 958 2 analysis analysis NN cord-015365-iqdi99pd 958 3 revealed reveal VBD cord-015365-iqdi99pd 958 4 clonal clonal JJ cord-015365-iqdi99pd 958 5 aberrations aberration NNS cord-015365-iqdi99pd 958 6 in in IN cord-015365-iqdi99pd 958 7 15/18 15/18 CD cord-015365-iqdi99pd 958 8 patients patient NNS cord-015365-iqdi99pd 958 9 . . . cord-015365-iqdi99pd 959 1 Nine nine CD cord-015365-iqdi99pd 959 2 patients patient NNS cord-015365-iqdi99pd 959 3 were be VBD cord-015365-iqdi99pd 959 4 transplanted transplant VBN cord-015365-iqdi99pd 959 5 in in IN cord-015365-iqdi99pd 959 6 1st 1st JJ cord-015365-iqdi99pd 959 7 CR cr NN cord-015365-iqdi99pd 959 8 , , , cord-015365-iqdi99pd 959 9 one one CD cord-015365-iqdi99pd 959 10 in in IN cord-015365-iqdi99pd 959 11 2nd 2nd JJ cord-015365-iqdi99pd 959 12 CR cr NN cord-015365-iqdi99pd 959 13 , , , cord-015365-iqdi99pd 959 14 five five CD cord-015365-iqdi99pd 959 15 in in IN cord-015365-iqdi99pd 959 16 PR PR NNP cord-015365-iqdi99pd 959 17 and and CC cord-015365-iqdi99pd 959 18 three three CD cord-015365-iqdi99pd 959 19 in in IN cord-015365-iqdi99pd 959 20 relapsed relapse VBN cord-015365-iqdi99pd 959 21 / / SYM cord-015365-iqdi99pd 959 22 refractory refractory JJ cord-015365-iqdi99pd 959 23 disease disease NN cord-015365-iqdi99pd 959 24 . . . cord-015365-iqdi99pd 960 1 Furthermore furthermore RB cord-015365-iqdi99pd 960 2 , , , cord-015365-iqdi99pd 960 3 five five CD cord-015365-iqdi99pd 960 4 patients patient NNS cord-015365-iqdi99pd 960 5 showed show VBD cord-015365-iqdi99pd 960 6 persistant persistant JJ cord-015365-iqdi99pd 960 7 primary primary JJ cord-015365-iqdi99pd 960 8 disease disease NN cord-015365-iqdi99pd 960 9 . . . cord-015365-iqdi99pd 961 1 Conditioning conditioning NN cord-015365-iqdi99pd 961 2 regimen regimen NN cord-015365-iqdi99pd 961 3 consisted consist VBD cord-015365-iqdi99pd 961 4 of of IN cord-015365-iqdi99pd 961 5 fludarabine fludarabine NN cord-015365-iqdi99pd 961 6 / / SYM cord-015365-iqdi99pd 961 7 melphalan melphalan NNP cord-015365-iqdi99pd 961 8 ( ( -LRB- cord-015365-iqdi99pd 961 9 n n NNP cord-015365-iqdi99pd 961 10 ¼ ¼ NNP cord-015365-iqdi99pd 961 11 15 15 CD cord-015365-iqdi99pd 961 12 ) ) -RRB- cord-015365-iqdi99pd 961 13 or or CC cord-015365-iqdi99pd 961 14 fludarabine/ fludarabine/ CD cord-015365-iqdi99pd 961 15 low low JJ cord-015365-iqdi99pd 961 16 - - HYPH cord-015365-iqdi99pd 961 17 dose dose NN cord-015365-iqdi99pd 961 18 TBI TBI NNP cord-015365-iqdi99pd 961 19 ( ( -LRB- cord-015365-iqdi99pd 961 20 n n NN cord-015365-iqdi99pd 961 21 ¼ ¼ NNP cord-015365-iqdi99pd 961 22 3 3 CD cord-015365-iqdi99pd 961 23 ) ) -RRB- cord-015365-iqdi99pd 961 24 . . . cord-015365-iqdi99pd 962 1 GvHD GvHD NNP cord-015365-iqdi99pd 962 2 prophylaxis prophylaxis NN cord-015365-iqdi99pd 962 3 consisted consist VBD cord-015365-iqdi99pd 962 4 of of IN cord-015365-iqdi99pd 962 5 cyclosporine cyclosporine NN cord-015365-iqdi99pd 962 6 and and CC cord-015365-iqdi99pd 962 7 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 962 8 mofetil mofetil NNP cord-015365-iqdi99pd 962 9 and and CC cord-015365-iqdi99pd 962 10 additionally additionally RB cord-015365-iqdi99pd 962 11 anti anti JJ cord-015365-iqdi99pd 962 12 - - JJ cord-015365-iqdi99pd 962 13 thymocyte thymocyte JJ cord-015365-iqdi99pd 962 14 globulin globulin NN cord-015365-iqdi99pd 962 15 in in IN cord-015365-iqdi99pd 962 16 unrelated unrelated JJ cord-015365-iqdi99pd 962 17 transplantations transplantation NNS cord-015365-iqdi99pd 962 18 . . . cord-015365-iqdi99pd 963 1 Results result NNS cord-015365-iqdi99pd 963 2 . . . cord-015365-iqdi99pd 964 1 After after IN cord-015365-iqdi99pd 964 2 a a DT cord-015365-iqdi99pd 964 3 median median JJ cord-015365-iqdi99pd 964 4 follow follow NN cord-015365-iqdi99pd 964 5 - - HYPH cord-015365-iqdi99pd 964 6 up up NN cord-015365-iqdi99pd 964 7 of of IN cord-015365-iqdi99pd 964 8 31 31 CD cord-015365-iqdi99pd 964 9 months month NNS cord-015365-iqdi99pd 964 10 ( ( -LRB- cord-015365-iqdi99pd 964 11 range range NN cord-015365-iqdi99pd 964 12 : : : cord-015365-iqdi99pd 964 13 3 3 CD cord-015365-iqdi99pd 964 14 - - SYM cord-015365-iqdi99pd 964 15 97 97 CD cord-015365-iqdi99pd 964 16 ) ) -RRB- cord-015365-iqdi99pd 964 17 9 9 CD cord-015365-iqdi99pd 964 18 patients patient NNS cord-015365-iqdi99pd 964 19 are be VBP cord-015365-iqdi99pd 964 20 alive alive JJ cord-015365-iqdi99pd 964 21 and and CC cord-015365-iqdi99pd 964 22 in in IN cord-015365-iqdi99pd 964 23 CR CR NNP cord-015365-iqdi99pd 964 24 . . . cord-015365-iqdi99pd 965 1 Causes cause NNS cord-015365-iqdi99pd 965 2 of of IN cord-015365-iqdi99pd 965 3 death death NN cord-015365-iqdi99pd 965 4 were be VBD cord-015365-iqdi99pd 965 5 : : : cord-015365-iqdi99pd 965 6 relapse relapse NN cord-015365-iqdi99pd 965 7 ( ( -LRB- cord-015365-iqdi99pd 965 8 n n NN cord-015365-iqdi99pd 965 9 ¼ ¼ NNP cord-015365-iqdi99pd 965 10 4 4 CD cord-015365-iqdi99pd 965 11 ) ) -RRB- cord-015365-iqdi99pd 965 12 , , , cord-015365-iqdi99pd 965 13 sepsis sepsis NN cord-015365-iqdi99pd 965 14 / / SYM cord-015365-iqdi99pd 965 15 multiorgan multiorgan NNP cord-015365-iqdi99pd 965 16 failure failure NN cord-015365-iqdi99pd 965 17 ( ( -LRB- cord-015365-iqdi99pd 965 18 n n NN cord-015365-iqdi99pd 965 19 ¼ ¼ NNP cord-015365-iqdi99pd 965 20 4 4 CD cord-015365-iqdi99pd 965 21 ) ) -RRB- cord-015365-iqdi99pd 965 22 and and CC cord-015365-iqdi99pd 965 23 GvHD GvHD NNP cord-015365-iqdi99pd 965 24 ( ( -LRB- cord-015365-iqdi99pd 965 25 n n NN cord-015365-iqdi99pd 965 26 ¼ ¼ NNP cord-015365-iqdi99pd 965 27 1 1 CD cord-015365-iqdi99pd 965 28 ) ) -RRB- cord-015365-iqdi99pd 965 29 . . . cord-015365-iqdi99pd 966 1 Acute acute JJ cord-015365-iqdi99pd 966 2 and and CC cord-015365-iqdi99pd 966 3 chronic chronic JJ cord-015365-iqdi99pd 966 4 GvHD GvHD NNP cord-015365-iqdi99pd 966 5 was be VBD cord-015365-iqdi99pd 966 6 observed observe VBN cord-015365-iqdi99pd 966 7 in in IN cord-015365-iqdi99pd 966 8 6 6 CD cord-015365-iqdi99pd 966 9 and and CC cord-015365-iqdi99pd 966 10 5 5 CD cord-015365-iqdi99pd 966 11 patients patient NNS cord-015365-iqdi99pd 966 12 , , , cord-015365-iqdi99pd 966 13 respectively respectively RB cord-015365-iqdi99pd 966 14 . . . cord-015365-iqdi99pd 967 1 The the DT cord-015365-iqdi99pd 967 2 estimated estimate VBN cord-015365-iqdi99pd 967 3 OS os NN cord-015365-iqdi99pd 967 4 is be VBZ cord-015365-iqdi99pd 967 5 53.8 53.8 CD cord-015365-iqdi99pd 967 6 % % NN cord-015365-iqdi99pd 967 7 at at IN cord-015365-iqdi99pd 967 8 one one CD cord-015365-iqdi99pd 967 9 and and CC cord-015365-iqdi99pd 967 10 47.9 47.9 CD cord-015365-iqdi99pd 967 11 % % NN cord-015365-iqdi99pd 967 12 at at IN cord-015365-iqdi99pd 967 13 three three CD cord-015365-iqdi99pd 967 14 years year NNS cord-015365-iqdi99pd 967 15 ; ; : cord-015365-iqdi99pd 967 16 the the DT cord-015365-iqdi99pd 967 17 DFS DFS NNP cord-015365-iqdi99pd 967 18 is be VBZ cord-015365-iqdi99pd 967 19 48.1 48.1 CD cord-015365-iqdi99pd 967 20 % % NN cord-015365-iqdi99pd 967 21 at at IN cord-015365-iqdi99pd 967 22 one one CD cord-015365-iqdi99pd 967 23 and and CC cord-015365-iqdi99pd 967 24 three three CD cord-015365-iqdi99pd 967 25 years year NNS cord-015365-iqdi99pd 967 26 , , , cord-015365-iqdi99pd 967 27 respectively respectively RB cord-015365-iqdi99pd 967 28 . . . cord-015365-iqdi99pd 968 1 Of of IN cord-015365-iqdi99pd 968 2 5 5 CD cord-015365-iqdi99pd 968 3 patients patient NNS cord-015365-iqdi99pd 968 4 transplanted transplant VBN cord-015365-iqdi99pd 968 5 with with IN cord-015365-iqdi99pd 968 6 active active JJ cord-015365-iqdi99pd 968 7 primary primary JJ cord-015365-iqdi99pd 968 8 neoplasms neoplasm NNS cord-015365-iqdi99pd 968 9 , , , cord-015365-iqdi99pd 968 10 2 2 CD cord-015365-iqdi99pd 968 11 are be VBP cord-015365-iqdi99pd 968 12 alive alive JJ cord-015365-iqdi99pd 968 13 at at IN cord-015365-iqdi99pd 968 14 1 1 CD cord-015365-iqdi99pd 968 15 year year NN cord-015365-iqdi99pd 968 16 showing show VBG cord-015365-iqdi99pd 968 17 CR cr NN cord-015365-iqdi99pd 968 18 of of IN cord-015365-iqdi99pd 968 19 both both DT cord-015365-iqdi99pd 968 20 primary primary JJ cord-015365-iqdi99pd 968 21 and and CC cord-015365-iqdi99pd 968 22 secondary secondary JJ cord-015365-iqdi99pd 968 23 neoplasms neoplasm NNS cord-015365-iqdi99pd 968 24 which which WDT cord-015365-iqdi99pd 968 25 was be VBD cord-015365-iqdi99pd 968 26 associated associate VBN cord-015365-iqdi99pd 968 27 with with IN cord-015365-iqdi99pd 968 28 the the DT cord-015365-iqdi99pd 968 29 development development NN cord-015365-iqdi99pd 968 30 of of IN cord-015365-iqdi99pd 968 31 chronic chronic JJ cord-015365-iqdi99pd 968 32 GvHD GvHD NNP cord-015365-iqdi99pd 968 33 . . . cord-015365-iqdi99pd 969 1 Conclusions conclusion NNS cord-015365-iqdi99pd 969 2 . . . cord-015365-iqdi99pd 970 1 The the DT cord-015365-iqdi99pd 970 2 results result NNS cord-015365-iqdi99pd 970 3 of of IN cord-015365-iqdi99pd 970 4 RIC RIC NNP cord-015365-iqdi99pd 970 5 HSCT HSCT NNP cord-015365-iqdi99pd 970 6 in in IN cord-015365-iqdi99pd 970 7 these these DT cord-015365-iqdi99pd 970 8 patients patient NNS cord-015365-iqdi99pd 970 9 with with IN cord-015365-iqdi99pd 970 10 poor poor JJ cord-015365-iqdi99pd 970 11 risk risk NN cord-015365-iqdi99pd 970 12 disease disease NN cord-015365-iqdi99pd 970 13 are be VBP cord-015365-iqdi99pd 970 14 encouraging encourage VBG cord-015365-iqdi99pd 970 15 with with IN cord-015365-iqdi99pd 970 16 respect respect NN cord-015365-iqdi99pd 970 17 to to IN cord-015365-iqdi99pd 970 18 TRM TRM NNP cord-015365-iqdi99pd 970 19 , , , cord-015365-iqdi99pd 970 20 relapse relapse NN cord-015365-iqdi99pd 970 21 rate rate NN cord-015365-iqdi99pd 970 22 and and CC cord-015365-iqdi99pd 970 23 overall overall JJ cord-015365-iqdi99pd 970 24 survival survival NN cord-015365-iqdi99pd 970 25 . . . cord-015365-iqdi99pd 971 1 Our -PRON- PRP$ cord-015365-iqdi99pd 971 2 data datum NNS cord-015365-iqdi99pd 971 3 show show VBP cord-015365-iqdi99pd 971 4 a a DT cord-015365-iqdi99pd 971 5 more more RBR cord-015365-iqdi99pd 971 6 favourable favourable JJ cord-015365-iqdi99pd 971 7 outcome outcome NN cord-015365-iqdi99pd 971 8 compared compare VBN cord-015365-iqdi99pd 971 9 with with IN cord-015365-iqdi99pd 971 10 previous previous JJ cord-015365-iqdi99pd 971 11 reports report NNS cord-015365-iqdi99pd 971 12 using use VBG cord-015365-iqdi99pd 971 13 a a DT cord-015365-iqdi99pd 971 14 myeloablative myeloablative JJ cord-015365-iqdi99pd 971 15 conditioning conditioning NN cord-015365-iqdi99pd 971 16 . . . cord-015365-iqdi99pd 972 1 Furthermore furthermore RB cord-015365-iqdi99pd 972 2 , , , cord-015365-iqdi99pd 972 3 allogeneic allogeneic IN cord-015365-iqdi99pd 972 4 HSCT HSCT NNP cord-015365-iqdi99pd 972 5 should should MD cord-015365-iqdi99pd 972 6 be be VB cord-015365-iqdi99pd 972 7 considered consider VBN cord-015365-iqdi99pd 972 8 as as IN cord-015365-iqdi99pd 972 9 a a DT cord-015365-iqdi99pd 972 10 potentially potentially RB cord-015365-iqdi99pd 972 11 curative curative JJ cord-015365-iqdi99pd 972 12 strategy strategy NN cord-015365-iqdi99pd 972 13 for for IN cord-015365-iqdi99pd 972 14 patients patient NNS cord-015365-iqdi99pd 972 15 with with IN cord-015365-iqdi99pd 972 16 t t NNP cord-015365-iqdi99pd 972 17 - - HYPH cord-015365-iqdi99pd 972 18 MNs MNs NNP cord-015365-iqdi99pd 972 19 and and CC cord-015365-iqdi99pd 972 20 persistant persistant JJ cord-015365-iqdi99pd 972 21 primary primary JJ cord-015365-iqdi99pd 972 22 malignancy malignancy NN cord-015365-iqdi99pd 972 23 . . . cord-015365-iqdi99pd 973 1 The the DT cord-015365-iqdi99pd 973 2 bone bone NN cord-015365-iqdi99pd 973 3 component component NN cord-015365-iqdi99pd 973 4 of of IN cord-015365-iqdi99pd 973 5 CTA CTA NNP cord-015365-iqdi99pd 973 6 gives give VBZ cord-015365-iqdi99pd 973 7 rise rise NN cord-015365-iqdi99pd 973 8 to to IN cord-015365-iqdi99pd 973 9 donor donor NN cord-015365-iqdi99pd 973 10 HSCs hsc NNS cord-015365-iqdi99pd 973 11 which which WDT cord-015365-iqdi99pd 973 12 migrate migrate VBP cord-015365-iqdi99pd 973 13 to to IN cord-015365-iqdi99pd 973 14 recipient recipient NN cord-015365-iqdi99pd 973 15 thymus thymus NN cord-015365-iqdi99pd 973 16 and and CC cord-015365-iqdi99pd 973 17 differentiate differentiate VB cord-015365-iqdi99pd 973 18 to to TO cord-015365-iqdi99pd 973 19 mature mature VB cord-015365-iqdi99pd 973 20 T t NN cord-015365-iqdi99pd 973 21 cells cell NNS cord-015365-iqdi99pd 973 22 Background background NN cord-015365-iqdi99pd 973 23 . . . cord-015365-iqdi99pd 974 1 Composite composite JJ cord-015365-iqdi99pd 974 2 Tissue tissue NN cord-015365-iqdi99pd 974 3 Allotransplantation Allotransplantation NNP cord-015365-iqdi99pd 974 4 ( ( -LRB- cord-015365-iqdi99pd 974 5 CTA CTA NNP cord-015365-iqdi99pd 974 6 ) ) -RRB- cord-015365-iqdi99pd 974 7 is be VBZ cord-015365-iqdi99pd 974 8 immunologically immunologically RB cord-015365-iqdi99pd 974 9 unique unique JJ cord-015365-iqdi99pd 974 10 in in IN cord-015365-iqdi99pd 974 11 that that IN cord-015365-iqdi99pd 974 12 it -PRON- PRP cord-015365-iqdi99pd 974 13 represents represent VBZ cord-015365-iqdi99pd 974 14 the the DT cord-015365-iqdi99pd 974 15 only only JJ cord-015365-iqdi99pd 974 16 type type NN cord-015365-iqdi99pd 974 17 of of IN cord-015365-iqdi99pd 974 18 graft graft NN cord-015365-iqdi99pd 974 19 to to TO cord-015365-iqdi99pd 974 20 include include VB cord-015365-iqdi99pd 974 21 a a DT cord-015365-iqdi99pd 974 22 vascularized vascularized JJ cord-015365-iqdi99pd 974 23 functional functional JJ cord-015365-iqdi99pd 974 24 bone bone NN cord-015365-iqdi99pd 974 25 marrow marrow NN cord-015365-iqdi99pd 974 26 component component NN cord-015365-iqdi99pd 974 27 . . . cord-015365-iqdi99pd 975 1 Here here RB cord-015365-iqdi99pd 975 2 we -PRON- PRP cord-015365-iqdi99pd 975 3 studied study VBD cord-015365-iqdi99pd 975 4 if if IN cord-015365-iqdi99pd 975 5 the the DT cord-015365-iqdi99pd 975 6 bone bone NN cord-015365-iqdi99pd 975 7 component component NN cord-015365-iqdi99pd 975 8 of of IN cord-015365-iqdi99pd 975 9 a a DT cord-015365-iqdi99pd 975 10 composite composite JJ cord-015365-iqdi99pd 975 11 tissue tissue NN cord-015365-iqdi99pd 975 12 graft graft NN cord-015365-iqdi99pd 975 13 represents represent VBZ cord-015365-iqdi99pd 975 14 the the DT cord-015365-iqdi99pd 975 15 source source NN cord-015365-iqdi99pd 975 16 of of IN cord-015365-iqdi99pd 975 17 HSCs HSCs NNP cord-015365-iqdi99pd 975 18 that that WDT cord-015365-iqdi99pd 975 19 differentiate differentiate VBP cord-015365-iqdi99pd 975 20 in in IN cord-015365-iqdi99pd 975 21 the the DT cord-015365-iqdi99pd 975 22 thymus thymus NN cord-015365-iqdi99pd 975 23 and and CC cord-015365-iqdi99pd 975 24 thereby thereby RB cord-015365-iqdi99pd 975 25 reconstitute reconstitute VB cord-015365-iqdi99pd 975 26 a a DT cord-015365-iqdi99pd 975 27 functional functional JJ cord-015365-iqdi99pd 975 28 immune immune JJ cord-015365-iqdi99pd 975 29 system system NN cord-015365-iqdi99pd 975 30 ( ( -LRB- cord-015365-iqdi99pd 975 31 CD3þ CD3þ NNP cord-015365-iqdi99pd 975 32 T T NNP cord-015365-iqdi99pd 975 33 cells cell NNS cord-015365-iqdi99pd 975 34 in in IN cord-015365-iqdi99pd 975 35 peripheral peripheral JJ cord-015365-iqdi99pd 975 36 blood blood NN cord-015365-iqdi99pd 975 37 / / SYM cord-015365-iqdi99pd 975 38 lymphoid lymphoid JJ cord-015365-iqdi99pd 975 39 organs organ NNS cord-015365-iqdi99pd 975 40 ) ) -RRB- cord-015365-iqdi99pd 975 41 in in IN cord-015365-iqdi99pd 975 42 immuno immuno JJ cord-015365-iqdi99pd 975 43 - - HYPH cord-015365-iqdi99pd 975 44 deficient deficient JJ cord-015365-iqdi99pd 975 45 B6 b6 NN cord-015365-iqdi99pd 975 46 / / SYM cord-015365-iqdi99pd 975 47 SCID SCID NNP cord-015365-iqdi99pd 975 48 recipients recipient NNS cord-015365-iqdi99pd 975 49 rather rather RB cord-015365-iqdi99pd 975 50 than than IN cord-015365-iqdi99pd 975 51 originate originate VB cord-015365-iqdi99pd 975 52 from from IN cord-015365-iqdi99pd 975 53 donor donor NN cord-015365-iqdi99pd 975 54 mature mature JJ cord-015365-iqdi99pd 975 55 passenger passenger NN cord-015365-iqdi99pd 975 56 T t NN cord-015365-iqdi99pd 975 57 cells cell NNS cord-015365-iqdi99pd 975 58 that that WDT cord-015365-iqdi99pd 975 59 expand expand VBP cord-015365-iqdi99pd 975 60 in in IN cord-015365-iqdi99pd 975 61 the the DT cord-015365-iqdi99pd 975 62 host host NN cord-015365-iqdi99pd 975 63 . . . cord-015365-iqdi99pd 976 1 Methods method NNS cord-015365-iqdi99pd 976 2 . . . cord-015365-iqdi99pd 977 1 B6 B6 NNP cord-015365-iqdi99pd 977 2 ( ( -LRB- cord-015365-iqdi99pd 977 3 WT WT NNP cord-015365-iqdi99pd 977 4 / / SYM cord-015365-iqdi99pd 977 5 nude nude NNP cord-015365-iqdi99pd 977 6 ) ) -RRB- cord-015365-iqdi99pd 977 7 murine murine JJ cord-015365-iqdi99pd 977 8 composite composite JJ cord-015365-iqdi99pd 977 9 tissue tissue NN cord-015365-iqdi99pd 977 10 grafts graft NNS cord-015365-iqdi99pd 977 11 ( ( -LRB- cord-015365-iqdi99pd 977 12 osteomyocutaneous osteomyocutaneous NNP cord-015365-iqdi99pd 977 13 or or CC cord-015365-iqdi99pd 977 14 myocutaneous myocutaneous NNP cord-015365-iqdi99pd 977 15 ) ) -RRB- cord-015365-iqdi99pd 977 16 were be VBD cord-015365-iqdi99pd 977 17 transplanted transplant VBN cord-015365-iqdi99pd 977 18 heterotopically heterotopically NNS cord-015365-iqdi99pd 977 19 to to IN cord-015365-iqdi99pd 977 20 B6 B6 NNP cord-015365-iqdi99pd 977 21 ( ( -LRB- cord-015365-iqdi99pd 977 22 WT WT NNP cord-015365-iqdi99pd 977 23 / / SYM cord-015365-iqdi99pd 977 24 scid scid NN cord-015365-iqdi99pd 977 25 ) ) -RRB- cord-015365-iqdi99pd 977 26 recipients recipient NNS cord-015365-iqdi99pd 977 27 using use VBG cord-015365-iqdi99pd 977 28 a a DT cord-015365-iqdi99pd 977 29 non non JJ cord-015365-iqdi99pd 977 30 - - JJ cord-015365-iqdi99pd 977 31 suture suture JJ cord-015365-iqdi99pd 977 32 cuff cuff NN cord-015365-iqdi99pd 977 33 technique technique NN cord-015365-iqdi99pd 977 34 for for IN cord-015365-iqdi99pd 977 35 revascularization revascularization NN cord-015365-iqdi99pd 977 36 . . . cord-015365-iqdi99pd 978 1 Flow flow NN cord-015365-iqdi99pd 978 2 cytometry cytometry NN cord-015365-iqdi99pd 978 3 of of IN cord-015365-iqdi99pd 978 4 peripheral peripheral JJ cord-015365-iqdi99pd 978 5 blood blood NN cord-015365-iqdi99pd 978 6 ( ( -LRB- cord-015365-iqdi99pd 978 7 CD3þ CD3þ NNP cord-015365-iqdi99pd 978 8 , , , cord-015365-iqdi99pd 978 9 CD19þ CD19þ NNP cord-015365-iqdi99pd 978 10 ) ) -RRB- cord-015365-iqdi99pd 978 11 was be VBD cord-015365-iqdi99pd 978 12 performed perform VBN cord-015365-iqdi99pd 978 13 at at IN cord-015365-iqdi99pd 978 14 pod pod NNP cord-015365-iqdi99pd 978 15 7 7 CD cord-015365-iqdi99pd 978 16 , , , cord-015365-iqdi99pd 978 17 14 14 CD cord-015365-iqdi99pd 978 18 , , , cord-015365-iqdi99pd 978 19 21 21 CD cord-015365-iqdi99pd 978 20 , , , cord-015365-iqdi99pd 978 21 28 28 CD cord-015365-iqdi99pd 978 22 , , , cord-015365-iqdi99pd 978 23 56 56 CD cord-015365-iqdi99pd 978 24 . . . cord-015365-iqdi99pd 979 1 In in IN cord-015365-iqdi99pd 979 2 addition addition NN cord-015365-iqdi99pd 979 3 , , , cord-015365-iqdi99pd 979 4 histopathology histopathology NN cord-015365-iqdi99pd 979 5 ( ( -LRB- cord-015365-iqdi99pd 979 6 H&E H&E NNP cord-015365-iqdi99pd 979 7 ) ) -RRB- cord-015365-iqdi99pd 979 8 and and CC cord-015365-iqdi99pd 979 9 immunohistochemistry immunohistochemistry NN cord-015365-iqdi99pd 979 10 of of IN cord-015365-iqdi99pd 979 11 tissues tissue NNS cord-015365-iqdi99pd 979 12 was be VBD cord-015365-iqdi99pd 979 13 performed perform VBN cord-015365-iqdi99pd 979 14 at at IN cord-015365-iqdi99pd 979 15 indicated indicate VBN cord-015365-iqdi99pd 979 16 time time NN cord-015365-iqdi99pd 979 17 points point NNS cord-015365-iqdi99pd 979 18 . . . cord-015365-iqdi99pd 980 1 To to TO cord-015365-iqdi99pd 980 2 assess assess VB cord-015365-iqdi99pd 980 3 immunocompetence immunocompetence NN cord-015365-iqdi99pd 980 4 , , , cord-015365-iqdi99pd 980 5 allogeneic allogeneic IN cord-015365-iqdi99pd 980 6 skin skin NN cord-015365-iqdi99pd 980 7 grafts graft NNS cord-015365-iqdi99pd 980 8 ( ( -LRB- cord-015365-iqdi99pd 980 9 Balb Balb NNP cord-015365-iqdi99pd 980 10 / / SYM cord-015365-iqdi99pd 980 11 c c NN cord-015365-iqdi99pd 980 12 ) ) -RRB- cord-015365-iqdi99pd 980 13 were be VBD cord-015365-iqdi99pd 980 14 transplanted transplant VBN cord-015365-iqdi99pd 980 15 to to IN cord-015365-iqdi99pd 980 16 either either CC cord-015365-iqdi99pd 980 17 naïve naïve JJ cord-015365-iqdi99pd 980 18 B6 B6 NNP cord-015365-iqdi99pd 980 19 / / SYM cord-015365-iqdi99pd 980 20 nude nude JJ cord-015365-iqdi99pd 980 21 , , , cord-015365-iqdi99pd 980 22 naïve naïve JJ cord-015365-iqdi99pd 980 23 B6 B6 NNP cord-015365-iqdi99pd 980 24 / / , cord-015365-iqdi99pd 980 25 scid scid NN cord-015365-iqdi99pd 980 26 or or CC cord-015365-iqdi99pd 980 27 B6 B6 NNP cord-015365-iqdi99pd 980 28 / / SYM cord-015365-iqdi99pd 980 29 scid scid JJ cord-015365-iqdi99pd 980 30 mice mouse NNS cord-015365-iqdi99pd 980 31 that that WDT cord-015365-iqdi99pd 980 32 prior prior RB cord-015365-iqdi99pd 980 33 received receive VBD cord-015365-iqdi99pd 980 34 a a DT cord-015365-iqdi99pd 980 35 B6 b6 NN cord-015365-iqdi99pd 980 36 / / SYM cord-015365-iqdi99pd 980 37 nude nude JJ cord-015365-iqdi99pd 980 38 CTA CTA NNP cord-015365-iqdi99pd 980 39 . . . cord-015365-iqdi99pd 981 1 Results result NNS cord-015365-iqdi99pd 981 2 . . . cord-015365-iqdi99pd 982 1 The the DT cord-015365-iqdi99pd 982 2 surgical surgical JJ cord-015365-iqdi99pd 982 3 success success NN cord-015365-iqdi99pd 982 4 rate rate NN cord-015365-iqdi99pd 982 5 was be VBD cord-015365-iqdi99pd 982 6 85 85 CD cord-015365-iqdi99pd 982 7 % % NN cord-015365-iqdi99pd 982 8 in in IN cord-015365-iqdi99pd 982 9 all all DT cord-015365-iqdi99pd 982 10 groups group NNS cord-015365-iqdi99pd 982 11 . . . cord-015365-iqdi99pd 983 1 As as IN cord-015365-iqdi99pd 983 2 expected expect VBN cord-015365-iqdi99pd 983 3 no no DT cord-015365-iqdi99pd 983 4 CD3þ CD3þ NNP cord-015365-iqdi99pd 983 5 cells cell NNS cord-015365-iqdi99pd 983 6 and and CC cord-015365-iqdi99pd 983 7 no no DT cord-015365-iqdi99pd 983 8 rejection rejection NN cord-015365-iqdi99pd 983 9 of of IN cord-015365-iqdi99pd 983 10 skin skin NN cord-015365-iqdi99pd 983 11 allografts allograft NNS cord-015365-iqdi99pd 983 12 were be VBD cord-015365-iqdi99pd 983 13 detected detect VBN cord-015365-iqdi99pd 983 14 in in IN cord-015365-iqdi99pd 983 15 B6 b6 NN cord-015365-iqdi99pd 983 16 / / SYM cord-015365-iqdi99pd 983 17 nude nude NN cord-015365-iqdi99pd 983 18 and and CC cord-015365-iqdi99pd 983 19 B6 B6 NNP cord-015365-iqdi99pd 983 20 / / SYM cord-015365-iqdi99pd 983 21 scid scid JJ cord-015365-iqdi99pd 983 22 controls control NNS cord-015365-iqdi99pd 983 23 . . . cord-015365-iqdi99pd 984 1 B6 b6 NN cord-015365-iqdi99pd 984 2 / / SYM cord-015365-iqdi99pd 984 3 scid scid JJ cord-015365-iqdi99pd 984 4 mice mouse NNS cord-015365-iqdi99pd 984 5 that that WDT cord-015365-iqdi99pd 984 6 received receive VBD cord-015365-iqdi99pd 984 7 B6 B6 NNP cord-015365-iqdi99pd 984 8 / / SYM cord-015365-iqdi99pd 984 9 nude nude NNP cord-015365-iqdi99pd 984 10 osteomyocutaneous osteomyocutaneous NNP cord-015365-iqdi99pd 984 11 flaps flaps NNP cord-015365-iqdi99pd 984 12 demonstrated demonstrate VBD cord-015365-iqdi99pd 984 13 B B NNP cord-015365-iqdi99pd 984 14 and and CC cord-015365-iqdi99pd 984 15 T t NN cord-015365-iqdi99pd 984 16 cell cell NN cord-015365-iqdi99pd 984 17 immunity immunity NN cord-015365-iqdi99pd 984 18 from from IN cord-015365-iqdi99pd 984 19 pod pod NN cord-015365-iqdi99pd 984 20 7 7 CD cord-015365-iqdi99pd 984 21 and and CC cord-015365-iqdi99pd 984 22 21 21 CD cord-015365-iqdi99pd 984 23 respectively respectively RB cord-015365-iqdi99pd 984 24 . . . cord-015365-iqdi99pd 985 1 The the DT cord-015365-iqdi99pd 985 2 percentage percentage NN cord-015365-iqdi99pd 985 3 of of IN cord-015365-iqdi99pd 985 4 CD3þ CD3þ NNP cord-015365-iqdi99pd 985 5 and and CC cord-015365-iqdi99pd 985 6 CD19þ CD19þ NNP cord-015365-iqdi99pd 985 7 cells cell NNS cord-015365-iqdi99pd 985 8 within within IN cord-015365-iqdi99pd 985 9 peripheral peripheral JJ cord-015365-iqdi99pd 985 10 blood blood NN cord-015365-iqdi99pd 985 11 mononuclear mononuclear NN cord-015365-iqdi99pd 985 12 cells cell NNS cord-015365-iqdi99pd 985 13 steadily steadily RB cord-015365-iqdi99pd 985 14 increased increase VBD cord-015365-iqdi99pd 985 15 to to IN cord-015365-iqdi99pd 985 16 57.7 57.7 CD cord-015365-iqdi99pd 985 17 % % NN cord-015365-iqdi99pd 985 18 and and CC cord-015365-iqdi99pd 985 19 17.1 17.1 CD cord-015365-iqdi99pd 985 20 % % NN cord-015365-iqdi99pd 985 21 respectively respectively RB cord-015365-iqdi99pd 985 22 at at IN cord-015365-iqdi99pd 985 23 pod pod NN cord-015365-iqdi99pd 985 24 56 56 CD cord-015365-iqdi99pd 985 25 . . . cord-015365-iqdi99pd 986 1 Allogeneic allogeneic IN cord-015365-iqdi99pd 986 2 skin skin NN cord-015365-iqdi99pd 986 3 allografts allograft NNS cord-015365-iqdi99pd 986 4 were be VBD cord-015365-iqdi99pd 986 5 rejected reject VBN cord-015365-iqdi99pd 986 6 2 2 CD cord-015365-iqdi99pd 986 7 weeks week NNS cord-015365-iqdi99pd 986 8 after after IN cord-015365-iqdi99pd 986 9 transplantation transplantation NN cord-015365-iqdi99pd 986 10 . . . cord-015365-iqdi99pd 987 1 However however RB cord-015365-iqdi99pd 987 2 , , , cord-015365-iqdi99pd 987 3 no no DT cord-015365-iqdi99pd 987 4 B b NN cord-015365-iqdi99pd 987 5 and and CC cord-015365-iqdi99pd 987 6 T T NNP cord-015365-iqdi99pd 987 7 cell cell NN cord-015365-iqdi99pd 987 8 reconstitution reconstitution NN cord-015365-iqdi99pd 987 9 was be VBD cord-015365-iqdi99pd 987 10 observed observe VBN cord-015365-iqdi99pd 987 11 in in IN cord-015365-iqdi99pd 987 12 B6 B6 NNP cord-015365-iqdi99pd 987 13 / / SYM cord-015365-iqdi99pd 987 14 scid scid JJ cord-015365-iqdi99pd 987 15 mice mouse NNS cord-015365-iqdi99pd 987 16 receiving receive VBG cord-015365-iqdi99pd 987 17 B6 B6 NNP cord-015365-iqdi99pd 987 18 / / SYM cord-015365-iqdi99pd 987 19 nude nude JJ cord-015365-iqdi99pd 987 20 myocutaneous myocutaneous JJ cord-015365-iqdi99pd 987 21 flaps flaps NNP cord-015365-iqdi99pd 987 22 ( ( -LRB- cord-015365-iqdi99pd 987 23 without without IN cord-015365-iqdi99pd 987 24 bone bone NN cord-015365-iqdi99pd 987 25 component component NN cord-015365-iqdi99pd 987 26 ) ) -RRB- cord-015365-iqdi99pd 987 27 . . . cord-015365-iqdi99pd 988 1 Conclusions conclusion NNS cord-015365-iqdi99pd 988 2 . . . cord-015365-iqdi99pd 989 1 The the DT cord-015365-iqdi99pd 989 2 vascularized vascularized JJ cord-015365-iqdi99pd 989 3 bone bone NN cord-015365-iqdi99pd 989 4 marrow marrow NN cord-015365-iqdi99pd 989 5 component component NN cord-015365-iqdi99pd 989 6 of of IN cord-015365-iqdi99pd 989 7 CTA CTA NNP cord-015365-iqdi99pd 989 8 provides provide VBZ cord-015365-iqdi99pd 989 9 an an DT cord-015365-iqdi99pd 989 10 effective effective JJ cord-015365-iqdi99pd 989 11 source source NN cord-015365-iqdi99pd 989 12 of of IN cord-015365-iqdi99pd 989 13 HSCs hscs NN cord-015365-iqdi99pd 989 14 to to TO cord-015365-iqdi99pd 989 15 restore restore VB cord-015365-iqdi99pd 989 16 immunocompetence immunocompetence NN cord-015365-iqdi99pd 989 17 in in IN cord-015365-iqdi99pd 989 18 T T NNP cord-015365-iqdi99pd 989 19 - - HYPH cord-015365-iqdi99pd 989 20 and and CC cord-015365-iqdi99pd 989 21 B b NN cord-015365-iqdi99pd 989 22 - - HYPH cord-015365-iqdi99pd 989 23 cell cell NN cord-015365-iqdi99pd 989 24 deficient deficient JJ cord-015365-iqdi99pd 989 25 mice mouse NNS cord-015365-iqdi99pd 989 26 . . . cord-015365-iqdi99pd 990 1 This this DT cord-015365-iqdi99pd 990 2 might may MD cord-015365-iqdi99pd 990 3 also also RB cord-015365-iqdi99pd 990 4 contribute contribute VB cord-015365-iqdi99pd 990 5 to to IN cord-015365-iqdi99pd 990 6 chimerism chimerism NN cord-015365-iqdi99pd 990 7 induction induction NN cord-015365-iqdi99pd 990 8 and and CC cord-015365-iqdi99pd 990 9 maintenance maintenance NN cord-015365-iqdi99pd 990 10 after after IN cord-015365-iqdi99pd 990 11 CTA CTA NNP cord-015365-iqdi99pd 990 12 and and CC cord-015365-iqdi99pd 990 13 facilitate facilitate VB cord-015365-iqdi99pd 990 14 the the DT cord-015365-iqdi99pd 990 15 clinically clinically RB cord-015365-iqdi99pd 990 16 observed observe VBN cord-015365-iqdi99pd 990 17 immunoprivilege immunoprivilege NN cord-015365-iqdi99pd 990 18 of of IN cord-015365-iqdi99pd 990 19 CTAs CTAs NNPS cord-015365-iqdi99pd 990 20 . . . cord-015365-iqdi99pd 991 1 Early early RB cord-015365-iqdi99pd 991 2 in in IN cord-015365-iqdi99pd 991 3 vivo vivo NN cord-015365-iqdi99pd 991 4 signaling signal VBG cord-015365-iqdi99pd 991 5 events event NNS cord-015365-iqdi99pd 991 6 involved involve VBN cord-015365-iqdi99pd 991 7 in in IN cord-015365-iqdi99pd 991 8 neo neo NNP cord-015365-iqdi99pd 991 9 - - HYPH cord-015365-iqdi99pd 991 10 vasculogenesis vasculogenesis NNP cord-015365-iqdi99pd 991 11 via via IN cord-015365-iqdi99pd 991 12 stem stem NN cord-015365-iqdi99pd 991 13 cell cell NN cord-015365-iqdi99pd 991 14 transplantation transplantation NN cord-015365-iqdi99pd 991 15 using use VBG cord-015365-iqdi99pd 991 16 proteomic proteomic JJ cord-015365-iqdi99pd 991 17 profiling profiling NN cord-015365-iqdi99pd 991 18 Background background NN cord-015365-iqdi99pd 991 19 . . . cord-015365-iqdi99pd 992 1 The the DT cord-015365-iqdi99pd 992 2 precise precise JJ cord-015365-iqdi99pd 992 3 mechanisms mechanism NNS cord-015365-iqdi99pd 992 4 regulating regulate VBG cord-015365-iqdi99pd 992 5 human human JJ cord-015365-iqdi99pd 992 6 neo neo NNP cord-015365-iqdi99pd 992 7 - - HYPH cord-015365-iqdi99pd 992 8 vasculogenesis vasculogenesis NNP cord-015365-iqdi99pd 992 9 and and CC cord-015365-iqdi99pd 992 10 organ organ NN cord-015365-iqdi99pd 992 11 regeneration regeneration NN cord-015365-iqdi99pd 992 12 are be VBP cord-015365-iqdi99pd 992 13 still still RB cord-015365-iqdi99pd 992 14 unclear unclear JJ cord-015365-iqdi99pd 992 15 . . . cord-015365-iqdi99pd 993 1 It -PRON- PRP cord-015365-iqdi99pd 993 2 has have VBZ cord-015365-iqdi99pd 993 3 been be VBN cord-015365-iqdi99pd 993 4 shown show VBN cord-015365-iqdi99pd 993 5 that that IN cord-015365-iqdi99pd 993 6 neo neo NNP cord-015365-iqdi99pd 993 7 - - HYPH cord-015365-iqdi99pd 993 8 vasculogenesis vasculogenesis NNP cord-015365-iqdi99pd 993 9 can can MD cord-015365-iqdi99pd 993 10 be be VB cord-015365-iqdi99pd 993 11 induced induce VBN cord-015365-iqdi99pd 993 12 in in IN cord-015365-iqdi99pd 993 13 immunocompromised immunocompromised JJ cord-015365-iqdi99pd 993 14 NOD NOD NNP cord-015365-iqdi99pd 993 15 / / SYM cord-015365-iqdi99pd 993 16 scid scid NNP cord-015365-iqdi99pd 993 17 / / SYM cord-015365-iqdi99pd 993 18 IL-2-receptor il-2-receptor CD cord-015365-iqdi99pd 993 19 gamma gamma NN cord-015365-iqdi99pd 993 20 - - HYPH cord-015365-iqdi99pd 993 21 knockout knockout NN cord-015365-iqdi99pd 993 22 ( ( -LRB- cord-015365-iqdi99pd 993 23 NSG NSG NNP cord-015365-iqdi99pd 993 24 ) ) -RRB- cord-015365-iqdi99pd 993 25 mice mouse NNS cord-015365-iqdi99pd 993 26 in in IN cord-015365-iqdi99pd 993 27 vivo vivo NN cord-015365-iqdi99pd 993 28 by by IN cord-015365-iqdi99pd 993 29 transplantation transplantation NN cord-015365-iqdi99pd 993 30 of of IN cord-015365-iqdi99pd 993 31 human human JJ cord-015365-iqdi99pd 993 32 bone bone NN cord-015365-iqdi99pd 993 33 marrowderived marrowderive VBD cord-015365-iqdi99pd 993 34 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 993 35 stem stem NN cord-015365-iqdi99pd 993 36 and and CC cord-015365-iqdi99pd 993 37 progenitor progenitor NN cord-015365-iqdi99pd 993 38 cells cell NNS cord-015365-iqdi99pd 993 39 ( ( -LRB- cord-015365-iqdi99pd 993 40 hMSPCs hmspcs LS cord-015365-iqdi99pd 993 41 ) ) -RRB- cord-015365-iqdi99pd 993 42 and and CC cord-015365-iqdi99pd 993 43 umbilical umbilical JJ cord-015365-iqdi99pd 993 44 cord cord NN cord-015365-iqdi99pd 993 45 - - HYPH cord-015365-iqdi99pd 993 46 derived derive VBN cord-015365-iqdi99pd 993 47 endothelial endothelial JJ cord-015365-iqdi99pd 993 48 colony colony NN cord-015365-iqdi99pd 993 49 - - HYPH cord-015365-iqdi99pd 993 50 forming form VBG cord-015365-iqdi99pd 993 51 progenitor progenitor NN cord-015365-iqdi99pd 993 52 cells cell NNS cord-015365-iqdi99pd 993 53 ( ( -LRB- cord-015365-iqdi99pd 993 54 hECFCs hecfcs NN cord-015365-iqdi99pd 993 55 ) ) -RRB- cord-015365-iqdi99pd 993 56 , , , cord-015365-iqdi99pd 993 57 whereas whereas IN cord-015365-iqdi99pd 993 58 transplantation transplantation NN cord-015365-iqdi99pd 993 59 of of IN cord-015365-iqdi99pd 993 60 pure pure JJ cord-015365-iqdi99pd 993 61 hMSPC hMSPC NNP cord-015365-iqdi99pd 993 62 or or CC cord-015365-iqdi99pd 993 63 hECFC hecfc JJ cord-015365-iqdi99pd 993 64 cells cell NNS cord-015365-iqdi99pd 993 65 lack lack VBP cord-015365-iqdi99pd 993 66 the the DT cord-015365-iqdi99pd 993 67 capacity capacity NN cord-015365-iqdi99pd 993 68 to to TO cord-015365-iqdi99pd 993 69 form form VB cord-015365-iqdi99pd 993 70 stable stable JJ cord-015365-iqdi99pd 993 71 functional functional JJ cord-015365-iqdi99pd 993 72 vessels vessel NNS cord-015365-iqdi99pd 993 73 ( ( -LRB- cord-015365-iqdi99pd 993 74 Reinisch Reinisch NNP cord-015365-iqdi99pd 993 75 et et NNP cord-015365-iqdi99pd 993 76 al al NNP cord-015365-iqdi99pd 993 77 . . . cord-015365-iqdi99pd 994 1 , , , cord-015365-iqdi99pd 994 2 Blood blood NN cord-015365-iqdi99pd 994 3 , , , cord-015365-iqdi99pd 994 4 2009 2009 CD cord-015365-iqdi99pd 994 5 ) ) -RRB- cord-015365-iqdi99pd 994 6 . . . cord-015365-iqdi99pd 995 1 Understanding understand VBG cord-015365-iqdi99pd 995 2 the the DT cord-015365-iqdi99pd 995 3 activity activity NN cord-015365-iqdi99pd 995 4 of of IN cord-015365-iqdi99pd 995 5 the the DT cord-015365-iqdi99pd 995 6 mediators mediator NNS cord-015365-iqdi99pd 995 7 of of IN cord-015365-iqdi99pd 995 8 neo neo NNP cord-015365-iqdi99pd 995 9 - - HYPH cord-015365-iqdi99pd 995 10 vasculogenesis vasculogenesis NNP cord-015365-iqdi99pd 995 11 would would MD cord-015365-iqdi99pd 995 12 provide provide VB cord-015365-iqdi99pd 995 13 us -PRON- PRP cord-015365-iqdi99pd 995 14 with with IN cord-015365-iqdi99pd 995 15 tools tool NNS cord-015365-iqdi99pd 995 16 to to TO cord-015365-iqdi99pd 995 17 develop develop VB cord-015365-iqdi99pd 995 18 strategies strategy NNS cord-015365-iqdi99pd 995 19 for for IN cord-015365-iqdi99pd 995 20 therapeutic therapeutic JJ cord-015365-iqdi99pd 995 21 intervention intervention NN cord-015365-iqdi99pd 995 22 as as RB cord-015365-iqdi99pd 995 23 well well RB cord-015365-iqdi99pd 995 24 as as IN cord-015365-iqdi99pd 995 25 angiogenesis angiogenesis NN cord-015365-iqdi99pd 995 26 and and CC cord-015365-iqdi99pd 995 27 regenerative regenerative JJ cord-015365-iqdi99pd 995 28 applications application NNS cord-015365-iqdi99pd 995 29 . . . cord-015365-iqdi99pd 996 1 Methods method NNS cord-015365-iqdi99pd 996 2 . . . cord-015365-iqdi99pd 997 1 Autologous autologous JJ cord-015365-iqdi99pd 997 2 pairs pair NNS cord-015365-iqdi99pd 997 3 of of IN cord-015365-iqdi99pd 997 4 MSPCs mspc NNS cord-015365-iqdi99pd 997 5 and and CC cord-015365-iqdi99pd 997 6 ECFCs ecfc NNS cord-015365-iqdi99pd 997 7 were be VBD cord-015365-iqdi99pd 997 8 transplanted transplant VBN cord-015365-iqdi99pd 997 9 subcutaneously subcutaneously RB cord-015365-iqdi99pd 997 10 in in IN cord-015365-iqdi99pd 997 11 Matrigel Matrigel NNP cord-015365-iqdi99pd 997 12 plugs plug NNS cord-015365-iqdi99pd 997 13 at at IN cord-015365-iqdi99pd 997 14 a a DT cord-015365-iqdi99pd 997 15 ratio ratio NN cord-015365-iqdi99pd 997 16 of of IN cord-015365-iqdi99pd 997 17 20:80 20:80 CD cord-015365-iqdi99pd 997 18 into into IN cord-015365-iqdi99pd 997 19 NSG NSG NNP cord-015365-iqdi99pd 997 20 mice mouse NNS cord-015365-iqdi99pd 997 21 and and CC cord-015365-iqdi99pd 997 22 implants implant NNS cord-015365-iqdi99pd 997 23 were be VBD cord-015365-iqdi99pd 997 24 harvested harvest VBN cord-015365-iqdi99pd 997 25 1 1 CD cord-015365-iqdi99pd 997 26 day day NN cord-015365-iqdi99pd 997 27 post post NN cord-015365-iqdi99pd 997 28 transplantation transplantation NN cord-015365-iqdi99pd 997 29 to to TO cord-015365-iqdi99pd 997 30 investigate investigate VB cord-015365-iqdi99pd 997 31 proteomic proteomic JJ cord-015365-iqdi99pd 997 32 profiling profiling NN cord-015365-iqdi99pd 997 33 using use VBG cord-015365-iqdi99pd 997 34 KAM KAM NNP cord-015365-iqdi99pd 997 35 1.3 1.3 CD cord-015365-iqdi99pd 997 36 Antibody Antibody NNP cord-015365-iqdi99pd 997 37 Microarray Microarray NNP cord-015365-iqdi99pd 997 38 ( ( -LRB- cord-015365-iqdi99pd 997 39 www.kinexus.ca www.kinexus.ca NNP cord-015365-iqdi99pd 997 40 ) ) -RRB- cord-015365-iqdi99pd 997 41 , , , cord-015365-iqdi99pd 997 42 testing test VBG cord-015365-iqdi99pd 997 43 over over IN cord-015365-iqdi99pd 997 44 800 800 CD cord-015365-iqdi99pd 997 45 signaling signal VBG cord-015365-iqdi99pd 997 46 and and CC cord-015365-iqdi99pd 997 47 phospho phospho NN cord-015365-iqdi99pd 997 48 - - HYPH cord-015365-iqdi99pd 997 49 proteins protein NNS cord-015365-iqdi99pd 997 50 . . . cord-015365-iqdi99pd 998 1 The the DT cord-015365-iqdi99pd 998 2 state state NN cord-015365-iqdi99pd 998 3 of of IN cord-015365-iqdi99pd 998 4 vessel vessel NN cord-015365-iqdi99pd 998 5 formation formation NN cord-015365-iqdi99pd 998 6 and and CC cord-015365-iqdi99pd 998 7 stability stability NN cord-015365-iqdi99pd 998 8 of of IN cord-015365-iqdi99pd 998 9 the the DT cord-015365-iqdi99pd 998 10 transplants transplant NNS cord-015365-iqdi99pd 998 11 were be VBD cord-015365-iqdi99pd 998 12 verified verify VBN cord-015365-iqdi99pd 998 13 by by IN cord-015365-iqdi99pd 998 14 immunohistochemistry immunohistochemistry NN cord-015365-iqdi99pd 998 15 of of IN cord-015365-iqdi99pd 998 16 the the DT cord-015365-iqdi99pd 998 17 explants explant NNS cord-015365-iqdi99pd 998 18 2 2 CD cord-015365-iqdi99pd 998 19 and and CC cord-015365-iqdi99pd 998 20 8 8 CD cord-015365-iqdi99pd 998 21 weeks week NNS cord-015365-iqdi99pd 998 22 post post NN cord-015365-iqdi99pd 998 23 transplantation transplantation NN cord-015365-iqdi99pd 998 24 . . . cord-015365-iqdi99pd 999 1 Results result NNS cord-015365-iqdi99pd 999 2 . . . cord-015365-iqdi99pd 1000 1 Protein protein NN cord-015365-iqdi99pd 1000 2 microarray microarray NN cord-015365-iqdi99pd 1000 3 data data NN cord-015365-iqdi99pd 1000 4 analysis analysis NN cord-015365-iqdi99pd 1000 5 revealed reveal VBD cord-015365-iqdi99pd 1000 6 significant significant JJ cord-015365-iqdi99pd 1000 7 alteration alteration NN cord-015365-iqdi99pd 1000 8 in in IN cord-015365-iqdi99pd 1000 9 the the DT cord-015365-iqdi99pd 1000 10 expression expression NN cord-015365-iqdi99pd 1000 11 and and CC cord-015365-iqdi99pd 1000 12 activity activity NN cord-015365-iqdi99pd 1000 13 of of IN cord-015365-iqdi99pd 1000 14 components component NNS cord-015365-iqdi99pd 1000 15 1 1 CD cord-015365-iqdi99pd 1000 16 ) ) -RRB- cord-015365-iqdi99pd 1000 17 regulating regulate VBG cord-015365-iqdi99pd 1000 18 apoptosis apoptosis NN cord-015365-iqdi99pd 1000 19 , , , cord-015365-iqdi99pd 1000 20 mitotic mitotic JJ cord-015365-iqdi99pd 1000 21 check check NN cord-015365-iqdi99pd 1000 22 point point NN cord-015365-iqdi99pd 1000 23 control control NN cord-015365-iqdi99pd 1000 24 , , , cord-015365-iqdi99pd 1000 25 and and CC cord-015365-iqdi99pd 1000 26 centrosome centrosome NN cord-015365-iqdi99pd 1000 27 structure structure NN cord-015365-iqdi99pd 1000 28 ; ; : cord-015365-iqdi99pd 1000 29 2 2 LS cord-015365-iqdi99pd 1000 30 ) ) -RRB- cord-015365-iqdi99pd 1000 31 modulating modulate VBG cord-015365-iqdi99pd 1000 32 glycolysis glycolysis NN cord-015365-iqdi99pd 1000 33 and and CC cord-015365-iqdi99pd 1000 34 the the DT cord-015365-iqdi99pd 1000 35 coordinated coordinated JJ cord-015365-iqdi99pd 1000 36 expression expression NN cord-015365-iqdi99pd 1000 37 of of IN cord-015365-iqdi99pd 1000 38 cyto cyto JJ cord-015365-iqdi99pd 1000 39 - - JJ cord-015365-iqdi99pd 1000 40 protective protective JJ cord-015365-iqdi99pd 1000 41 genes gene NNS cord-015365-iqdi99pd 1000 42 ; ; : cord-015365-iqdi99pd 1000 43 and and CC cord-015365-iqdi99pd 1000 44 3 3 LS cord-015365-iqdi99pd 1000 45 ) ) -RRB- cord-015365-iqdi99pd 1000 46 mediating mediate VBG cord-015365-iqdi99pd 1000 47 cell cell NN cord-015365-iqdi99pd 1000 48 adhesion adhesion NN cord-015365-iqdi99pd 1000 49 , , , cord-015365-iqdi99pd 1000 50 migration migration NN cord-015365-iqdi99pd 1000 51 and and CC cord-015365-iqdi99pd 1000 52 tissue tissue NN cord-015365-iqdi99pd 1000 53 invasion invasion NN cord-015365-iqdi99pd 1000 54 . . . cord-015365-iqdi99pd 1001 1 Selected select VBN cord-015365-iqdi99pd 1001 2 targets target NNS cord-015365-iqdi99pd 1001 3 are be VBP cord-015365-iqdi99pd 1001 4 currently currently RB cord-015365-iqdi99pd 1001 5 being be VBG cord-015365-iqdi99pd 1001 6 validated validate VBN cord-015365-iqdi99pd 1001 7 by by IN cord-015365-iqdi99pd 1001 8 Western western JJ cord-015365-iqdi99pd 1001 9 blotting blotting NN cord-015365-iqdi99pd 1001 10 to to TO cord-015365-iqdi99pd 1001 11 allow allow VB cord-015365-iqdi99pd 1001 12 for for IN cord-015365-iqdi99pd 1001 13 the the DT cord-015365-iqdi99pd 1001 14 development development NN cord-015365-iqdi99pd 1001 15 of of IN cord-015365-iqdi99pd 1001 16 novel novel JJ cord-015365-iqdi99pd 1001 17 therapeutic therapeutic JJ cord-015365-iqdi99pd 1001 18 intervention intervention NN cord-015365-iqdi99pd 1001 19 strategies strategy NNS cord-015365-iqdi99pd 1001 20 . . . cord-015365-iqdi99pd 1002 1 A a DT cord-015365-iqdi99pd 1002 2 detailed detailed JJ cord-015365-iqdi99pd 1002 3 expression expression NN cord-015365-iqdi99pd 1002 4 and and CC cord-015365-iqdi99pd 1002 5 interactive interactive JJ cord-015365-iqdi99pd 1002 6 network network NN cord-015365-iqdi99pd 1002 7 analysis analysis NN cord-015365-iqdi99pd 1002 8 of of IN cord-015365-iqdi99pd 1002 9 targets target NNS cord-015365-iqdi99pd 1002 10 will will MD cord-015365-iqdi99pd 1002 11 be be VB cord-015365-iqdi99pd 1002 12 presented present VBN cord-015365-iqdi99pd 1002 13 and and CC cord-015365-iqdi99pd 1002 14 discussed discuss VBN cord-015365-iqdi99pd 1002 15 . . . cord-015365-iqdi99pd 1003 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1003 2 . . . cord-015365-iqdi99pd 1004 1 Our -PRON- PRP$ cord-015365-iqdi99pd 1004 2 data datum NNS cord-015365-iqdi99pd 1004 3 confirm confirm VBP cord-015365-iqdi99pd 1004 4 that that IN cord-015365-iqdi99pd 1004 5 more more JJR cord-015365-iqdi99pd 1004 6 than than IN cord-015365-iqdi99pd 1004 7 one one CD cord-015365-iqdi99pd 1004 8 purified purify VBN cord-015365-iqdi99pd 1004 9 cell cell NN cord-015365-iqdi99pd 1004 10 type type NN cord-015365-iqdi99pd 1004 11 is be VBZ cord-015365-iqdi99pd 1004 12 needed need VBN cord-015365-iqdi99pd 1004 13 for for IN cord-015365-iqdi99pd 1004 14 tissue tissue NN cord-015365-iqdi99pd 1004 15 engineering engineering NN cord-015365-iqdi99pd 1004 16 in in IN cord-015365-iqdi99pd 1004 17 vivo vivo NN cord-015365-iqdi99pd 1004 18 and and CC cord-015365-iqdi99pd 1004 19 suggest suggest VBP cord-015365-iqdi99pd 1004 20 that that IN cord-015365-iqdi99pd 1004 21 composite composite JJ cord-015365-iqdi99pd 1004 22 cellular cellular JJ cord-015365-iqdi99pd 1004 23 transplantation transplantation NN cord-015365-iqdi99pd 1004 24 may may MD cord-015365-iqdi99pd 1004 25 be be VB cord-015365-iqdi99pd 1004 26 useful useful JJ cord-015365-iqdi99pd 1004 27 for for IN cord-015365-iqdi99pd 1004 28 future future JJ cord-015365-iqdi99pd 1004 29 therapeutic therapeutic JJ cord-015365-iqdi99pd 1004 30 strategies strategy NNS cord-015365-iqdi99pd 1004 31 . . . cord-015365-iqdi99pd 1005 1 Proteomic proteomic NN cord-015365-iqdi99pd 1005 2 profiling profiling NN cord-015365-iqdi99pd 1005 3 unraveled unravel VBD cord-015365-iqdi99pd 1005 4 at at RB cord-015365-iqdi99pd 1005 5 least least RBS cord-015365-iqdi99pd 1005 6 three three CD cord-015365-iqdi99pd 1005 7 distinct distinct JJ cord-015365-iqdi99pd 1005 8 but but CC cord-015365-iqdi99pd 1005 9 partially partially RB cord-015365-iqdi99pd 1005 10 overlapping overlap VBG cord-015365-iqdi99pd 1005 11 signaling signal VBG cord-015365-iqdi99pd 1005 12 networks network NNS cord-015365-iqdi99pd 1005 13 involved involve VBN cord-015365-iqdi99pd 1005 14 in in IN cord-015365-iqdi99pd 1005 15 the the DT cord-015365-iqdi99pd 1005 16 complex complex JJ cord-015365-iqdi99pd 1005 17 process process NN cord-015365-iqdi99pd 1005 18 of of IN cord-015365-iqdi99pd 1005 19 vascular vascular JJ cord-015365-iqdi99pd 1005 20 regeneration regeneration NN cord-015365-iqdi99pd 1005 21 . . . cord-015365-iqdi99pd 1006 1 Understanding understand VBG cord-015365-iqdi99pd 1006 2 the the DT cord-015365-iqdi99pd 1006 3 origin origin NN cord-015365-iqdi99pd 1006 4 and and CC cord-015365-iqdi99pd 1006 5 activity activity NN cord-015365-iqdi99pd 1006 6 of of IN cord-015365-iqdi99pd 1006 7 the the DT cord-015365-iqdi99pd 1006 8 mediators mediator NNS cord-015365-iqdi99pd 1006 9 of of IN cord-015365-iqdi99pd 1006 10 vessel vessel NN cord-015365-iqdi99pd 1006 11 formation formation NN cord-015365-iqdi99pd 1006 12 and and CC cord-015365-iqdi99pd 1006 13 repair repair NN cord-015365-iqdi99pd 1006 14 would would MD cord-015365-iqdi99pd 1006 15 provide provide VB cord-015365-iqdi99pd 1006 16 us -PRON- PRP cord-015365-iqdi99pd 1006 17 with with IN cord-015365-iqdi99pd 1006 18 tools tool NNS cord-015365-iqdi99pd 1006 19 to to TO cord-015365-iqdi99pd 1006 20 develop develop VB cord-015365-iqdi99pd 1006 21 and and CC cord-015365-iqdi99pd 1006 22 further far RBR cord-015365-iqdi99pd 1006 23 optimize optimize VB cord-015365-iqdi99pd 1006 24 novel novel JJ cord-015365-iqdi99pd 1006 25 cell cell NN cord-015365-iqdi99pd 1006 26 transplantation transplantation NN cord-015365-iqdi99pd 1006 27 strategies strategy NNS cord-015365-iqdi99pd 1006 28 . . . cord-015365-iqdi99pd 1007 1 Oxygen oxygen NN cord-015365-iqdi99pd 1007 2 sensing sensing NN cord-015365-iqdi99pd 1007 3 of of IN cord-015365-iqdi99pd 1007 4 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 1007 5 stem stem NN cord-015365-iqdi99pd 1007 6 and and CC cord-015365-iqdi99pd 1007 7 progenitor progenitor NN cord-015365-iqdi99pd 1007 8 cells cell NNS cord-015365-iqdi99pd 1007 9 promotes promote VBZ cord-015365-iqdi99pd 1007 10 neo neo NNP cord-015365-iqdi99pd 1007 11 - - HYPH cord-015365-iqdi99pd 1007 12 vasculogenesis vasculogenesis NNP cord-015365-iqdi99pd 1007 13 in in IN cord-015365-iqdi99pd 1007 14 vivo vivo NNP cord-015365-iqdi99pd 1007 15 Background Background NNP cord-015365-iqdi99pd 1007 16 . . . cord-015365-iqdi99pd 1008 1 Vascular vascular JJ cord-015365-iqdi99pd 1008 2 regeneration regeneration NN cord-015365-iqdi99pd 1008 3 requires require VBZ cord-015365-iqdi99pd 1008 4 a a DT cord-015365-iqdi99pd 1008 5 stringent stringent JJ cord-015365-iqdi99pd 1008 6 interaction interaction NN cord-015365-iqdi99pd 1008 7 of of IN cord-015365-iqdi99pd 1008 8 somatic somatic JJ cord-015365-iqdi99pd 1008 9 endothelial endothelial JJ cord-015365-iqdi99pd 1008 10 colony colony NN cord-015365-iqdi99pd 1008 11 - - HYPH cord-015365-iqdi99pd 1008 12 forming form VBG cord-015365-iqdi99pd 1008 13 progenitor progenitor NN cord-015365-iqdi99pd 1008 14 cells cell NNS cord-015365-iqdi99pd 1008 15 ( ( -LRB- cord-015365-iqdi99pd 1008 16 ECFCs ECFCs NNP cord-015365-iqdi99pd 1008 17 ) ) -RRB- cord-015365-iqdi99pd 1008 18 with with IN cord-015365-iqdi99pd 1008 19 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 1008 20 stem stem NN cord-015365-iqdi99pd 1008 21 and and CC cord-015365-iqdi99pd 1008 22 progenitor progenitor NN cord-015365-iqdi99pd 1008 23 cells cell NNS cord-015365-iqdi99pd 1008 24 ( ( -LRB- cord-015365-iqdi99pd 1008 25 MSPCs mspc NNS cord-015365-iqdi99pd 1008 26 ) ) -RRB- cord-015365-iqdi99pd 1008 27 . . . cord-015365-iqdi99pd 1009 1 Hypoxia hypoxia NN cord-015365-iqdi99pd 1009 2 in in IN cord-015365-iqdi99pd 1009 3 ischemic ischemic JJ cord-015365-iqdi99pd 1009 4 tissue tissue NN cord-015365-iqdi99pd 1009 5 is be VBZ cord-015365-iqdi99pd 1009 6 a a DT cord-015365-iqdi99pd 1009 7 key key JJ cord-015365-iqdi99pd 1009 8 factor factor NN cord-015365-iqdi99pd 1009 9 driving drive VBG cord-015365-iqdi99pd 1009 10 the the DT cord-015365-iqdi99pd 1009 11 revascularization revascularization NN cord-015365-iqdi99pd 1009 12 machinery machinery NN cord-015365-iqdi99pd 1009 13 . . . cord-015365-iqdi99pd 1010 1 Because because IN cord-015365-iqdi99pd 1010 2 ECFCs ECFCs NNP cord-015365-iqdi99pd 1010 3 , , , cord-015365-iqdi99pd 1010 4 despite despite IN cord-015365-iqdi99pd 1010 5 hypoxic hypoxic JJ cord-015365-iqdi99pd 1010 6 stimulation stimulation NN cord-015365-iqdi99pd 1010 7 , , , cord-015365-iqdi99pd 1010 8 only only RB cord-015365-iqdi99pd 1010 9 form form NN cord-015365-iqdi99pd 1010 10 patent patent NN cord-015365-iqdi99pd 1010 11 vessels vessel NNS cord-015365-iqdi99pd 1010 12 in in IN cord-015365-iqdi99pd 1010 13 vivo vivo NN cord-015365-iqdi99pd 1010 14 in in IN cord-015365-iqdi99pd 1010 15 the the DT cord-015365-iqdi99pd 1010 16 presence presence NN cord-015365-iqdi99pd 1010 17 of of IN cord-015365-iqdi99pd 1010 18 MSPCs mspc NNS cord-015365-iqdi99pd 1010 19 , , , cord-015365-iqdi99pd 1010 20 we -PRON- PRP cord-015365-iqdi99pd 1010 21 hypothesized hypothesize VBD cord-015365-iqdi99pd 1010 22 that that IN cord-015365-iqdi99pd 1010 23 MSPCs mspc NNS cord-015365-iqdi99pd 1010 24 play play VB cord-015365-iqdi99pd 1010 25 a a DT cord-015365-iqdi99pd 1010 26 decisive decisive JJ cord-015365-iqdi99pd 1010 27 role role NN cord-015365-iqdi99pd 1010 28 in in IN cord-015365-iqdi99pd 1010 29 oxygen oxygen NN cord-015365-iqdi99pd 1010 30 sensing sensing NN cord-015365-iqdi99pd 1010 31 during during IN cord-015365-iqdi99pd 1010 32 vasculogenesis vasculogenesis NN cord-015365-iqdi99pd 1010 33 . . . cord-015365-iqdi99pd 1011 1 Methods method NNS cord-015365-iqdi99pd 1011 2 . . . cord-015365-iqdi99pd 1012 1 Adult adult JJ cord-015365-iqdi99pd 1012 2 human human NN cord-015365-iqdi99pd 1012 3 ECFCs ecfc NNS cord-015365-iqdi99pd 1012 4 were be VBD cord-015365-iqdi99pd 1012 5 isolated isolate VBN cord-015365-iqdi99pd 1012 6 directly directly RB cord-015365-iqdi99pd 1012 7 from from IN cord-015365-iqdi99pd 1012 8 whole whole JJ cord-015365-iqdi99pd 1012 9 venous venous JJ cord-015365-iqdi99pd 1012 10 blood blood NN cord-015365-iqdi99pd 1012 11 and and CC cord-015365-iqdi99pd 1012 12 MSPCs mspc NNS cord-015365-iqdi99pd 1012 13 from from IN cord-015365-iqdi99pd 1012 14 human human JJ cord-015365-iqdi99pd 1012 15 bone bone NN cord-015365-iqdi99pd 1012 16 marrow marrow NN cord-015365-iqdi99pd 1012 17 aspirates aspirate NNS cord-015365-iqdi99pd 1012 18 . . . cord-015365-iqdi99pd 1013 1 Pooled pool VBN cord-015365-iqdi99pd 1013 2 human human JJ cord-015365-iqdi99pd 1013 3 platelet platelet NN cord-015365-iqdi99pd 1013 4 lysate lysate NN cord-015365-iqdi99pd 1013 5 entirely entirely RB cord-015365-iqdi99pd 1013 6 replaced replace VBD cord-015365-iqdi99pd 1013 7 fetal fetal JJ cord-015365-iqdi99pd 1013 8 bovine bovine JJ cord-015365-iqdi99pd 1013 9 serum serum NN cord-015365-iqdi99pd 1013 10 during during IN cord-015365-iqdi99pd 1013 11 cell cell NN cord-015365-iqdi99pd 1013 12 culture culture NN cord-015365-iqdi99pd 1013 13 . . . cord-015365-iqdi99pd 1014 1 Progenitor progenitor NN cord-015365-iqdi99pd 1014 2 cell cell NN cord-015365-iqdi99pd 1014 3 phenotype phenotype NN cord-015365-iqdi99pd 1014 4 , , , cord-015365-iqdi99pd 1014 5 long long JJ cord-015365-iqdi99pd 1014 6 - - HYPH cord-015365-iqdi99pd 1014 7 term term NN cord-015365-iqdi99pd 1014 8 proliferation proliferation NN cord-015365-iqdi99pd 1014 9 , , , cord-015365-iqdi99pd 1014 10 molecular molecular JJ cord-015365-iqdi99pd 1014 11 cellular cellular JJ cord-015365-iqdi99pd 1014 12 response response NN cord-015365-iqdi99pd 1014 13 , , , cord-015365-iqdi99pd 1014 14 wound wind VBD cord-015365-iqdi99pd 1014 15 repair repair NN cord-015365-iqdi99pd 1014 16 as as RB cord-015365-iqdi99pd 1014 17 well well RB cord-015365-iqdi99pd 1014 18 as as IN cord-015365-iqdi99pd 1014 19 migratory migratory JJ cord-015365-iqdi99pd 1014 20 and and CC cord-015365-iqdi99pd 1014 21 vasculogenic vasculogenic JJ cord-015365-iqdi99pd 1014 22 functions function NNS cord-015365-iqdi99pd 1014 23 were be VBD cord-015365-iqdi99pd 1014 24 monitored monitor VBN cord-015365-iqdi99pd 1014 25 under under IN cord-015365-iqdi99pd 1014 26 reduced reduce VBN cord-015365-iqdi99pd 1014 27 oxygen oxygen NN cord-015365-iqdi99pd 1014 28 levels level NNS cord-015365-iqdi99pd 1014 29 ( ( -LRB- cord-015365-iqdi99pd 1014 30 5 5 CD cord-015365-iqdi99pd 1014 31 % % NN cord-015365-iqdi99pd 1014 32 O o NN cord-015365-iqdi99pd 1014 33 2 2 CD cord-015365-iqdi99pd 1014 34 ) ) -RRB- cord-015365-iqdi99pd 1014 35 , , , cord-015365-iqdi99pd 1014 36 severe severe JJ cord-015365-iqdi99pd 1014 37 hypoxia hypoxia NN cord-015365-iqdi99pd 1014 38 ( ( -LRB- cord-015365-iqdi99pd 1014 39 1 1 CD cord-015365-iqdi99pd 1014 40 % % NN cord-015365-iqdi99pd 1014 41 O o NN cord-015365-iqdi99pd 1014 42 2 2 CD cord-015365-iqdi99pd 1014 43 ) ) -RRB- cord-015365-iqdi99pd 1014 44 and and CC cord-015365-iqdi99pd 1014 45 standard standard JJ cord-015365-iqdi99pd 1014 46 culture culture NN cord-015365-iqdi99pd 1014 47 conditions condition NNS cord-015365-iqdi99pd 1014 48 ( ( -LRB- cord-015365-iqdi99pd 1014 49 20 20 CD cord-015365-iqdi99pd 1014 50 % % NN cord-015365-iqdi99pd 1014 51 O o NN cord-015365-iqdi99pd 1014 52 2 2 CD cord-015365-iqdi99pd 1014 53 ) ) -RRB- cord-015365-iqdi99pd 1014 54 . . . cord-015365-iqdi99pd 1015 1 ECFC ECFC NNP cord-015365-iqdi99pd 1015 2 and and CC cord-015365-iqdi99pd 1015 3 MSPC MSPC NNP cord-015365-iqdi99pd 1015 4 interaction interaction NN cord-015365-iqdi99pd 1015 5 in in IN cord-015365-iqdi99pd 1015 6 vivo vivo NN cord-015365-iqdi99pd 1015 7 and and CC cord-015365-iqdi99pd 1015 8 the the DT cord-015365-iqdi99pd 1015 9 influence influence NN cord-015365-iqdi99pd 1015 10 of of IN cord-015365-iqdi99pd 1015 11 protein protein NN cord-015365-iqdi99pd 1015 12 synthesis synthesis NN cord-015365-iqdi99pd 1015 13 were be VBD cord-015365-iqdi99pd 1015 14 studied study VBN cord-015365-iqdi99pd 1015 15 in in IN cord-015365-iqdi99pd 1015 16 immune immune NN cord-015365-iqdi99pd 1015 17 - - HYPH cord-015365-iqdi99pd 1015 18 deficient deficient JJ cord-015365-iqdi99pd 1015 19 NSG NSG NNP cord-015365-iqdi99pd 1015 20 mice mouse NNS cord-015365-iqdi99pd 1015 21 after after IN cord-015365-iqdi99pd 1015 22 subcutaneous subcutaneous JJ cord-015365-iqdi99pd 1015 23 injection injection NN cord-015365-iqdi99pd 1015 24 with with IN cord-015365-iqdi99pd 1015 25 matrigel matrigel NNP cord-015365-iqdi99pd 1015 26 . . . cord-015365-iqdi99pd 1016 1 Immune immune JJ cord-015365-iqdi99pd 1016 2 histochemistry histochemistry NN cord-015365-iqdi99pd 1016 3 and and CC cord-015365-iqdi99pd 1016 4 TUNEL TUNEL NNP cord-015365-iqdi99pd 1016 5 assays assay NNS cord-015365-iqdi99pd 1016 6 were be VBD cord-015365-iqdi99pd 1016 7 performed perform VBN cord-015365-iqdi99pd 1016 8 on on IN cord-015365-iqdi99pd 1016 9 explants explant NNS cord-015365-iqdi99pd 1016 10 in in IN cord-015365-iqdi99pd 1016 11 the the DT cord-015365-iqdi99pd 1016 12 time time NN cord-015365-iqdi99pd 1016 13 course course NN cord-015365-iqdi99pd 1016 14 after after IN cord-015365-iqdi99pd 1016 15 transplantation transplantation NN cord-015365-iqdi99pd 1016 16 . . . cord-015365-iqdi99pd 1017 1 Results result NNS cord-015365-iqdi99pd 1017 2 . . . cord-015365-iqdi99pd 1018 1 In in IN cord-015365-iqdi99pd 1018 2 vitro vitro FW cord-015365-iqdi99pd 1018 3 ECFC ECFC NNP cord-015365-iqdi99pd 1018 4 and and CC cord-015365-iqdi99pd 1018 5 MSPC MSPC NNP cord-015365-iqdi99pd 1018 6 proliferation proliferation NN cord-015365-iqdi99pd 1018 7 was be VBD cord-015365-iqdi99pd 1018 8 reduced reduce VBN cord-015365-iqdi99pd 1018 9 with with IN cord-015365-iqdi99pd 1018 10 declining decline VBG cord-015365-iqdi99pd 1018 11 oxygen oxygen NN cord-015365-iqdi99pd 1018 12 levels level NNS cord-015365-iqdi99pd 1018 13 , , , cord-015365-iqdi99pd 1018 14 while while IN cord-015365-iqdi99pd 1018 15 the the DT cord-015365-iqdi99pd 1018 16 absolute absolute JJ cord-015365-iqdi99pd 1018 17 colony colony NN cord-015365-iqdi99pd 1018 18 number number NN cord-015365-iqdi99pd 1018 19 remained remain VBD cord-015365-iqdi99pd 1018 20 unchanged unchanged JJ cord-015365-iqdi99pd 1018 21 . . . cord-015365-iqdi99pd 1019 1 ECFC ECFC NNP cord-015365-iqdi99pd 1019 2 vascular vascular JJ cord-015365-iqdi99pd 1019 3 wound wind VBD cord-015365-iqdi99pd 1019 4 repair repair NN cord-015365-iqdi99pd 1019 5 and and CC cord-015365-iqdi99pd 1019 6 vascular vascular JJ cord-015365-iqdi99pd 1019 7 - - HYPH cord-015365-iqdi99pd 1019 8 like like JJ cord-015365-iqdi99pd 1019 9 network network NN cord-015365-iqdi99pd 1019 10 formation formation NN cord-015365-iqdi99pd 1019 11 in in IN cord-015365-iqdi99pd 1019 12 vitro vitro FW cord-015365-iqdi99pd 1019 13 improved improve VBN cord-015365-iqdi99pd 1019 14 with with IN cord-015365-iqdi99pd 1019 15 escalating escalate VBG cord-015365-iqdi99pd 1019 16 oxygen oxygen NN cord-015365-iqdi99pd 1019 17 supply supply NN cord-015365-iqdi99pd 1019 18 . . . cord-015365-iqdi99pd 1020 1 ECFCs ECFCs NNP cord-015365-iqdi99pd 1020 2 stabilize stabilize VB cord-015365-iqdi99pd 1020 3 hypoxia hypoxia NN cord-015365-iqdi99pd 1020 4 - - HYPH cord-015365-iqdi99pd 1020 5 inducing induce VBG cord-015365-iqdi99pd 1020 6 factor-1 factor-1 NNP cord-015365-iqdi99pd 1021 1 ( ( -LRB- cord-015365-iqdi99pd 1021 2 HIF-1 HIF-1 NNP cord-015365-iqdi99pd 1021 3 ) ) -RRB- cord-015365-iqdi99pd 1021 4 only only RB cord-015365-iqdi99pd 1021 5 under under IN cord-015365-iqdi99pd 1021 6 1 1 CD cord-015365-iqdi99pd 1021 7 % % NN cord-015365-iqdi99pd 1021 8 O o NN cord-015365-iqdi99pd 1021 9 2 2 CD cord-015365-iqdi99pd 1021 10 , , , cord-015365-iqdi99pd 1021 11 while while IN cord-015365-iqdi99pd 1021 12 MSPCs mspc NNS cord-015365-iqdi99pd 1021 13 stabilize stabilize VBP cord-015365-iqdi99pd 1021 14 HIF-1 HIF-1 NNP cord-015365-iqdi99pd 1021 15 under under IN cord-015365-iqdi99pd 1021 16 1 1 CD cord-015365-iqdi99pd 1021 17 % % NN cord-015365-iqdi99pd 1021 18 O o NN cord-015365-iqdi99pd 1021 19 2 2 CD cord-015365-iqdi99pd 1021 20 as as RB cord-015365-iqdi99pd 1021 21 well well RB cord-015365-iqdi99pd 1021 22 as as IN cord-015365-iqdi99pd 1021 23 5 5 CD cord-015365-iqdi99pd 1021 24 % % NN cord-015365-iqdi99pd 1021 25 O o NN cord-015365-iqdi99pd 1021 26 2 2 CD cord-015365-iqdi99pd 1021 27 conditions condition NNS cord-015365-iqdi99pd 1021 28 . . . cord-015365-iqdi99pd 1022 1 In in IN cord-015365-iqdi99pd 1022 2 a a DT cord-015365-iqdi99pd 1022 3 mouse mouse NN cord-015365-iqdi99pd 1022 4 model model NN cord-015365-iqdi99pd 1022 5 , , , cord-015365-iqdi99pd 1022 6 injected inject VBN cord-015365-iqdi99pd 1022 7 ECFCs ECFCs NNP cord-015365-iqdi99pd 1022 8 underwent undergo VBD cord-015365-iqdi99pd 1022 9 apoptosis apoptosis NN cord-015365-iqdi99pd 1022 10 after after IN cord-015365-iqdi99pd 1022 11 1 1 CD cord-015365-iqdi99pd 1022 12 day day NN cord-015365-iqdi99pd 1022 13 and and CC cord-015365-iqdi99pd 1022 14 attracted attract VBD cord-015365-iqdi99pd 1022 15 mouse mouse NN cord-015365-iqdi99pd 1022 16 leucocytes leucocyte NNS cord-015365-iqdi99pd 1022 17 . . . cord-015365-iqdi99pd 1023 1 In in IN cord-015365-iqdi99pd 1023 2 vivo vivo NN cord-015365-iqdi99pd 1023 3 co co JJ cord-015365-iqdi99pd 1023 4 - - JJ cord-015365-iqdi99pd 1023 5 cultured cultured JJ cord-015365-iqdi99pd 1023 6 ECFCs ecfc NNS cord-015365-iqdi99pd 1023 7 and and CC cord-015365-iqdi99pd 1023 8 MSPCs mspc NNS cord-015365-iqdi99pd 1023 9 formed form VBD cord-015365-iqdi99pd 1023 10 perfused perfuse VBN cord-015365-iqdi99pd 1023 11 human human JJ cord-015365-iqdi99pd 1023 12 vessels vessel NNS cord-015365-iqdi99pd 1023 13 7 7 CD cord-015365-iqdi99pd 1023 14 days day NNS cord-015365-iqdi99pd 1023 15 after after IN cord-015365-iqdi99pd 1023 16 transplantation transplantation NN cord-015365-iqdi99pd 1023 17 . . . cord-015365-iqdi99pd 1024 1 Perivascular Perivascular NNP cord-015365-iqdi99pd 1024 2 cells cell NNS cord-015365-iqdi99pd 1024 3 , , , cord-015365-iqdi99pd 1024 4 but but CC cord-015365-iqdi99pd 1024 5 not not RB cord-015365-iqdi99pd 1024 6 ECFCs ECFCs NNP cord-015365-iqdi99pd 1024 7 , , , cord-015365-iqdi99pd 1024 8 in in IN cord-015365-iqdi99pd 1024 9 vivo vivo NNP cord-015365-iqdi99pd 1024 10 were be VBD cord-015365-iqdi99pd 1024 11 positive positive JJ cord-015365-iqdi99pd 1024 12 for for IN cord-015365-iqdi99pd 1024 13 HIF-1 HIF-1 NNP cord-015365-iqdi99pd 1024 14 . . . cord-015365-iqdi99pd 1025 1 Inhibition inhibition NN cord-015365-iqdi99pd 1025 2 of of IN cord-015365-iqdi99pd 1025 3 MSPC MSPC NNP cord-015365-iqdi99pd 1025 4 , , , cord-015365-iqdi99pd 1025 5 but but CC cord-015365-iqdi99pd 1025 6 not not RB cord-015365-iqdi99pd 1025 7 ECFC ECFC NNP cord-015365-iqdi99pd 1025 8 , , , cord-015365-iqdi99pd 1025 9 protein protein NN cord-015365-iqdi99pd 1025 10 synthesis synthesis NN cord-015365-iqdi99pd 1025 11 and and CC cord-015365-iqdi99pd 1025 12 HIF-1 HIF-1 NNP cord-015365-iqdi99pd 1025 13 stabilization stabilization NN cord-015365-iqdi99pd 1025 14 prior prior RB cord-015365-iqdi99pd 1025 15 to to IN cord-015365-iqdi99pd 1025 16 co co JJ cord-015365-iqdi99pd 1025 17 - - NN cord-015365-iqdi99pd 1025 18 implantation implantation JJ cord-015365-iqdi99pd 1025 19 blocked block VBN cord-015365-iqdi99pd 1025 20 vessel vessel NN cord-015365-iqdi99pd 1025 21 formation formation NN cord-015365-iqdi99pd 1025 22 . . . cord-015365-iqdi99pd 1026 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1026 2 . . . cord-015365-iqdi99pd 1027 1 These these DT cord-015365-iqdi99pd 1027 2 data datum NNS cord-015365-iqdi99pd 1027 3 indicate indicate VBP cord-015365-iqdi99pd 1027 4 that that IN cord-015365-iqdi99pd 1027 5 hypoxic hypoxic JJ cord-015365-iqdi99pd 1027 6 ECFCs ecfc NNS cord-015365-iqdi99pd 1027 7 alone alone RB cord-015365-iqdi99pd 1027 8 are be VBP cord-015365-iqdi99pd 1027 9 not not RB cord-015365-iqdi99pd 1027 10 able able JJ cord-015365-iqdi99pd 1027 11 to to TO cord-015365-iqdi99pd 1027 12 function function VB cord-015365-iqdi99pd 1027 13 in in IN cord-015365-iqdi99pd 1027 14 vitro vitro FW cord-015365-iqdi99pd 1027 15 and and CC cord-015365-iqdi99pd 1027 16 form form VB cord-015365-iqdi99pd 1027 17 patent patent NN cord-015365-iqdi99pd 1027 18 vessels vessel NNS cord-015365-iqdi99pd 1027 19 in in IN cord-015365-iqdi99pd 1027 20 vivo vivo NN cord-015365-iqdi99pd 1027 21 . . . cord-015365-iqdi99pd 1028 1 MSPCs mspc NNS cord-015365-iqdi99pd 1028 2 react react VB cord-015365-iqdi99pd 1028 3 to to IN cord-015365-iqdi99pd 1028 4 the the DT cord-015365-iqdi99pd 1028 5 low low JJ cord-015365-iqdi99pd 1028 6 oxygen oxygen NN cord-015365-iqdi99pd 1028 7 environment environment NN cord-015365-iqdi99pd 1028 8 and and CC cord-015365-iqdi99pd 1028 9 promote promote VB cord-015365-iqdi99pd 1028 10 ECFCs ecfc NNS cord-015365-iqdi99pd 1028 11 to to TO cord-015365-iqdi99pd 1028 12 form form VB cord-015365-iqdi99pd 1028 13 vessels vessel NNS cord-015365-iqdi99pd 1028 14 at at IN cord-015365-iqdi99pd 1028 15 least least JJS cord-015365-iqdi99pd 1028 16 in in IN cord-015365-iqdi99pd 1028 17 part part NN cord-015365-iqdi99pd 1028 18 by by IN cord-015365-iqdi99pd 1028 19 rescuing rescue VBG cord-015365-iqdi99pd 1028 20 ECFCs ecfc NNS cord-015365-iqdi99pd 1028 21 from from IN cord-015365-iqdi99pd 1028 22 hypoxia hypoxia NN cord-015365-iqdi99pd 1028 23 - - HYPH cord-015365-iqdi99pd 1028 24 induced induce VBN cord-015365-iqdi99pd 1028 25 apoptosis apoptosis NN cord-015365-iqdi99pd 1028 26 . . . cord-015365-iqdi99pd 1029 1 This this DT cord-015365-iqdi99pd 1029 2 suggests suggest VBZ cord-015365-iqdi99pd 1029 3 that that IN cord-015365-iqdi99pd 1029 4 oxygen oxygen NN cord-015365-iqdi99pd 1029 5 sensing sensing NN cord-015365-iqdi99pd 1029 6 MSPCs mspc NNS cord-015365-iqdi99pd 1029 7 are be VBP cord-015365-iqdi99pd 1029 8 a a DT cord-015365-iqdi99pd 1029 9 key key JJ cord-015365-iqdi99pd 1029 10 factor factor NN cord-015365-iqdi99pd 1029 11 in in IN cord-015365-iqdi99pd 1029 12 stem stem NN cord-015365-iqdi99pd 1029 13 cell cell NN cord-015365-iqdi99pd 1029 14 transplantation transplantation NN cord-015365-iqdi99pd 1029 15 and and CC cord-015365-iqdi99pd 1029 16 regenerative regenerative JJ cord-015365-iqdi99pd 1029 17 medicine medicine NN cord-015365-iqdi99pd 1029 18 . . . cord-015365-iqdi99pd 1030 1 Background background NN cord-015365-iqdi99pd 1030 2 . . . cord-015365-iqdi99pd 1031 1 Low low JJ cord-015365-iqdi99pd 1031 2 sensitivity sensitivity NN cord-015365-iqdi99pd 1031 3 and and CC cord-015365-iqdi99pd 1031 4 specificity specificity NN cord-015365-iqdi99pd 1031 5 rates rate NNS cord-015365-iqdi99pd 1031 6 for for IN cord-015365-iqdi99pd 1031 7 the the DT cord-015365-iqdi99pd 1031 8 detection detection NN cord-015365-iqdi99pd 1031 9 of of IN cord-015365-iqdi99pd 1031 10 invasive invasive JJ cord-015365-iqdi99pd 1031 11 pulmonary pulmonary JJ cord-015365-iqdi99pd 1031 12 mycosis mycosis NN cord-015365-iqdi99pd 1031 13 result result NN cord-015365-iqdi99pd 1031 14 in in IN cord-015365-iqdi99pd 1031 15 a a DT cord-015365-iqdi99pd 1031 16 major major JJ cord-015365-iqdi99pd 1031 17 cause cause NN cord-015365-iqdi99pd 1031 18 of of IN cord-015365-iqdi99pd 1031 19 mortality mortality NN cord-015365-iqdi99pd 1031 20 among among IN cord-015365-iqdi99pd 1031 21 immunosuppressed immunosuppressed JJ cord-015365-iqdi99pd 1031 22 children child NNS cord-015365-iqdi99pd 1031 23 . . . cord-015365-iqdi99pd 1032 1 We -PRON- PRP cord-015365-iqdi99pd 1032 2 sought seek VBD cord-015365-iqdi99pd 1032 3 to to TO cord-015365-iqdi99pd 1032 4 determine determine VB cord-015365-iqdi99pd 1032 5 the the DT cord-015365-iqdi99pd 1032 6 accuracy accuracy NN cord-015365-iqdi99pd 1032 7 of of IN cord-015365-iqdi99pd 1032 8 percutaneous percutaneous JJ cord-015365-iqdi99pd 1032 9 computed compute VBN cord-015365-iqdi99pd 1032 10 tomographyguided tomographyguide VBN cord-015365-iqdi99pd 1032 11 biopsy biopsy NN cord-015365-iqdi99pd 1032 12 in in IN cord-015365-iqdi99pd 1032 13 children child NNS cord-015365-iqdi99pd 1032 14 with with IN cord-015365-iqdi99pd 1032 15 cancer cancer NN cord-015365-iqdi99pd 1032 16 and and CC cord-015365-iqdi99pd 1032 17 hematopoetic hematopoetic JJ cord-015365-iqdi99pd 1032 18 stem stem NN cord-015365-iqdi99pd 1032 19 cell cell NN cord-015365-iqdi99pd 1032 20 transplantion transplantion NN cord-015365-iqdi99pd 1032 21 . . . cord-015365-iqdi99pd 1033 1 Methods method NNS cord-015365-iqdi99pd 1033 2 . . . cord-015365-iqdi99pd 1034 1 We -PRON- PRP cord-015365-iqdi99pd 1034 2 retrospectively retrospectively RB cord-015365-iqdi99pd 1034 3 reviewed review VBD cord-015365-iqdi99pd 1034 4 17 17 CD cord-015365-iqdi99pd 1034 5 imaging imaging NN cord-015365-iqdi99pd 1034 6 - - HYPH cord-015365-iqdi99pd 1034 7 guided guide VBN cord-015365-iqdi99pd 1034 8 percutaneous percutaneous JJ cord-015365-iqdi99pd 1034 9 biopsies biopsy NNS cord-015365-iqdi99pd 1034 10 of of IN cord-015365-iqdi99pd 1034 11 17 17 CD cord-015365-iqdi99pd 1034 12 children child NNS cord-015365-iqdi99pd 1034 13 for for IN cord-015365-iqdi99pd 1034 14 suspicious suspicious JJ cord-015365-iqdi99pd 1034 15 lesions lesion NNS cord-015365-iqdi99pd 1034 16 detected detect VBN cord-015365-iqdi99pd 1034 17 by by IN cord-015365-iqdi99pd 1034 18 computed compute VBN cord-015365-iqdi99pd 1034 19 tomography tomography NN cord-015365-iqdi99pd 1034 20 . . . cord-015365-iqdi99pd 1035 1 Thirteen thirteen CD cord-015365-iqdi99pd 1035 2 were be VBD cord-015365-iqdi99pd 1035 3 being be VBG cord-015365-iqdi99pd 1035 4 treated treat VBN cord-015365-iqdi99pd 1035 5 for for IN cord-015365-iqdi99pd 1035 6 hematologic hematologic JJ cord-015365-iqdi99pd 1035 7 malignancies malignancy NNS cord-015365-iqdi99pd 1035 8 , , , cord-015365-iqdi99pd 1035 9 three three CD cord-015365-iqdi99pd 1035 10 for for IN cord-015365-iqdi99pd 1035 11 solid solid JJ cord-015365-iqdi99pd 1035 12 tumors tumor NNS cord-015365-iqdi99pd 1035 13 , , , cord-015365-iqdi99pd 1035 14 one one CD cord-015365-iqdi99pd 1035 15 for for IN cord-015365-iqdi99pd 1035 16 immunodeficiency immunodeficiency NN cord-015365-iqdi99pd 1035 17 ; ; : cord-015365-iqdi99pd 1035 18 47 47 CD cord-015365-iqdi99pd 1035 19 % % NN cord-015365-iqdi99pd 1035 20 had have VBD cord-015365-iqdi99pd 1035 21 received receive VBN cord-015365-iqdi99pd 1035 22 allogeneic allogeneic IN cord-015365-iqdi99pd 1035 23 bone bone NN cord-015365-iqdi99pd 1035 24 marrow marrow NN cord-015365-iqdi99pd 1035 25 or or CC cord-015365-iqdi99pd 1035 26 peripheral peripheral JJ cord-015365-iqdi99pd 1035 27 stem stem NN cord-015365-iqdi99pd 1035 28 cell cell NN cord-015365-iqdi99pd 1035 29 transplants transplant NNS cord-015365-iqdi99pd 1035 30 . . . cord-015365-iqdi99pd 1036 1 The the DT cord-015365-iqdi99pd 1036 2 accuracy accuracy NN cord-015365-iqdi99pd 1036 3 of of IN cord-015365-iqdi99pd 1036 4 the the DT cord-015365-iqdi99pd 1036 5 percutaneous percutaneous JJ cord-015365-iqdi99pd 1036 6 lung lung NN cord-015365-iqdi99pd 1036 7 biopsy biopsy NN cord-015365-iqdi99pd 1036 8 was be VBD cord-015365-iqdi99pd 1036 9 determined determine VBN cord-015365-iqdi99pd 1036 10 by by IN cord-015365-iqdi99pd 1036 11 subsequent subsequent JJ cord-015365-iqdi99pd 1036 12 surgical surgical JJ cord-015365-iqdi99pd 1036 13 resection resection NN cord-015365-iqdi99pd 1036 14 , , , cord-015365-iqdi99pd 1036 15 autopsy autopsy JJ cord-015365-iqdi99pd 1036 16 , , , cord-015365-iqdi99pd 1036 17 or or CC cord-015365-iqdi99pd 1036 18 clinical clinical JJ cord-015365-iqdi99pd 1036 19 course course NN cord-015365-iqdi99pd 1036 20 . . . cord-015365-iqdi99pd 1037 1 Results result NNS cord-015365-iqdi99pd 1037 2 . . . cord-015365-iqdi99pd 1038 1 Histopathological Histopathological NNP cord-015365-iqdi99pd 1038 2 studies study NNS cord-015365-iqdi99pd 1038 3 showed show VBD cord-015365-iqdi99pd 1038 4 11 11 CD cord-015365-iqdi99pd 1038 5 biopsy biopsy NN cord-015365-iqdi99pd 1038 6 specimens specimen NNS cord-015365-iqdi99pd 1038 7 with with IN cord-015365-iqdi99pd 1038 8 septate septate JJ cord-015365-iqdi99pd 1038 9 hyphae hypha NNS cord-015365-iqdi99pd 1038 10 , , , cord-015365-iqdi99pd 1038 11 indicating indicate VBG cord-015365-iqdi99pd 1038 12 a a DT cord-015365-iqdi99pd 1038 13 mold mold NN cord-015365-iqdi99pd 1038 14 , , , cord-015365-iqdi99pd 1038 15 including include VBG cord-015365-iqdi99pd 1038 16 6 6 CD cord-015365-iqdi99pd 1038 17 with with IN cord-015365-iqdi99pd 1038 18 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1038 19 , , , cord-015365-iqdi99pd 1038 20 4 4 CD cord-015365-iqdi99pd 1038 21 with with IN cord-015365-iqdi99pd 1038 22 Mycoraceae Mycoraceae NNP cord-015365-iqdi99pd 1038 23 , , , cord-015365-iqdi99pd 1038 24 1 1 CD cord-015365-iqdi99pd 1038 25 with with IN cord-015365-iqdi99pd 1038 26 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1038 27 and and CC cord-015365-iqdi99pd 1038 28 Mycoraceae Mycoraceae NNP cord-015365-iqdi99pd 1038 29 colonies colony NNS cord-015365-iqdi99pd 1038 30 in in IN cord-015365-iqdi99pd 1038 31 culture culture NN cord-015365-iqdi99pd 1038 32 ; ; : cord-015365-iqdi99pd 1038 33 2 2 CD cord-015365-iqdi99pd 1038 34 specimens specimen NNS cord-015365-iqdi99pd 1038 35 revealed reveal VBD cord-015365-iqdi99pd 1038 36 Candida Candida NNP cord-015365-iqdi99pd 1038 37 , , , cord-015365-iqdi99pd 1038 38 1 1 CD cord-015365-iqdi99pd 1038 39 Saccharomyces saccharomyce NNS cord-015365-iqdi99pd 1038 40 . . . cord-015365-iqdi99pd 1039 1 The the DT cord-015365-iqdi99pd 1039 2 remaining remain VBG cord-015365-iqdi99pd 1039 3 3 3 CD cord-015365-iqdi99pd 1039 4 biopsies biopsy NNS cord-015365-iqdi99pd 1039 5 revealed reveal VBD cord-015365-iqdi99pd 1039 6 bronchiolits bronchiolit NNS cord-015365-iqdi99pd 1039 7 obliterans obliterans NN cord-015365-iqdi99pd 1039 8 pneumoniae pneumoniae NN cord-015365-iqdi99pd 1039 9 . . . cord-015365-iqdi99pd 1040 1 Invasive invasive JJ cord-015365-iqdi99pd 1040 2 pulmonary pulmonary JJ cord-015365-iqdi99pd 1040 3 mycosis mycosis NN cord-015365-iqdi99pd 1040 4 was be VBD cord-015365-iqdi99pd 1040 5 detected detect VBN cord-015365-iqdi99pd 1040 6 by by IN cord-015365-iqdi99pd 1040 7 percutaneous percutaneous JJ cord-015365-iqdi99pd 1040 8 biopsy biopsy NN cord-015365-iqdi99pd 1040 9 with with IN cord-015365-iqdi99pd 1040 10 100 100 CD cord-015365-iqdi99pd 1040 11 % % NN cord-015365-iqdi99pd 1040 12 sensitivity sensitivity NN cord-015365-iqdi99pd 1040 13 and and CC cord-015365-iqdi99pd 1040 14 100 100 CD cord-015365-iqdi99pd 1040 15 % % NN cord-015365-iqdi99pd 1040 16 ( ( -LRB- cord-015365-iqdi99pd 1040 17 14/14 14/14 CD cord-015365-iqdi99pd 1040 18 ) ) -RRB- cord-015365-iqdi99pd 1040 19 specificity specificity NN cord-015365-iqdi99pd 1040 20 . . . cord-015365-iqdi99pd 1041 1 Percutaneous Percutaneous NNP cord-015365-iqdi99pd 1041 2 biopsy biopsy NN cord-015365-iqdi99pd 1041 3 results result NNS cord-015365-iqdi99pd 1041 4 influenced influence VBD cord-015365-iqdi99pd 1041 5 the the DT cord-015365-iqdi99pd 1041 6 surgical surgical JJ cord-015365-iqdi99pd 1041 7 decision decision NN cord-015365-iqdi99pd 1041 8 in in IN cord-015365-iqdi99pd 1041 9 21 21 CD cord-015365-iqdi99pd 1041 10 % % NN cord-015365-iqdi99pd 1041 11 ( ( -LRB- cord-015365-iqdi99pd 1041 12 3 3 CD cord-015365-iqdi99pd 1041 13 of of IN cord-015365-iqdi99pd 1041 14 14 14 CD cord-015365-iqdi99pd 1041 15 ) ) -RRB- cord-015365-iqdi99pd 1041 16 and and CC cord-015365-iqdi99pd 1041 17 changed change VBD cord-015365-iqdi99pd 1041 18 the the DT cord-015365-iqdi99pd 1041 19 treatment treatment NN cord-015365-iqdi99pd 1041 20 option option NN cord-015365-iqdi99pd 1041 21 in in IN cord-015365-iqdi99pd 1041 22 78 78 CD cord-015365-iqdi99pd 1041 23 % % NN cord-015365-iqdi99pd 1041 24 of of IN cord-015365-iqdi99pd 1041 25 the the DT cord-015365-iqdi99pd 1041 26 cases case NNS cord-015365-iqdi99pd 1041 27 . . . cord-015365-iqdi99pd 1042 1 Pneumothorax Pneumothorax NNP cord-015365-iqdi99pd 1042 2 complicated complicate VBD cord-015365-iqdi99pd 1042 3 the the DT cord-015365-iqdi99pd 1042 4 biopsy biopsy NN cord-015365-iqdi99pd 1042 5 in in IN cord-015365-iqdi99pd 1042 6 one one CD cord-015365-iqdi99pd 1042 7 patient patient NN cord-015365-iqdi99pd 1042 8 . . . cord-015365-iqdi99pd 1043 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1043 2 . . . cord-015365-iqdi99pd 1044 1 Percutaneous Percutaneous NNP cord-015365-iqdi99pd 1044 2 computed compute VBD cord-015365-iqdi99pd 1044 3 tomography tomography NN cord-015365-iqdi99pd 1044 4 - - HYPH cord-015365-iqdi99pd 1044 5 guided guide VBN cord-015365-iqdi99pd 1044 6 biopsy biopsy NN cord-015365-iqdi99pd 1044 7 is be VBZ cord-015365-iqdi99pd 1044 8 an an DT cord-015365-iqdi99pd 1044 9 accurate accurate JJ cord-015365-iqdi99pd 1044 10 technique technique NN cord-015365-iqdi99pd 1044 11 for for IN cord-015365-iqdi99pd 1044 12 the the DT cord-015365-iqdi99pd 1044 13 diagnosis diagnosis NN cord-015365-iqdi99pd 1044 14 of of IN cord-015365-iqdi99pd 1044 15 invasive invasive JJ cord-015365-iqdi99pd 1044 16 pulmonary pulmonary JJ cord-015365-iqdi99pd 1044 17 mycosis mycosis NN cord-015365-iqdi99pd 1044 18 in in IN cord-015365-iqdi99pd 1044 19 children child NNS cord-015365-iqdi99pd 1044 20 . . . cord-015365-iqdi99pd 1045 1 It -PRON- PRP cord-015365-iqdi99pd 1045 2 reveals reveal VBZ cord-015365-iqdi99pd 1045 3 the the DT cord-015365-iqdi99pd 1045 4 local local JJ cord-015365-iqdi99pd 1045 5 epidemiology epidemiology NN cord-015365-iqdi99pd 1045 6 , , , cord-015365-iqdi99pd 1045 7 correctly correctly RB cord-015365-iqdi99pd 1045 8 determines determine VBZ cord-015365-iqdi99pd 1045 9 the the DT cord-015365-iqdi99pd 1045 10 therapeutic therapeutic JJ cord-015365-iqdi99pd 1045 11 anti anti JJ cord-015365-iqdi99pd 1045 12 - - JJ cord-015365-iqdi99pd 1045 13 mycotic mycotic JJ cord-015365-iqdi99pd 1045 14 agent agent NN cord-015365-iqdi99pd 1045 15 and and CC cord-015365-iqdi99pd 1045 16 influences influence VBZ cord-015365-iqdi99pd 1045 17 the the DT cord-015365-iqdi99pd 1045 18 choice choice NN cord-015365-iqdi99pd 1045 19 of of IN cord-015365-iqdi99pd 1045 20 prophylaxis prophylaxis NN cord-015365-iqdi99pd 1045 21 for for IN cord-015365-iqdi99pd 1045 22 invasive invasive JJ cord-015365-iqdi99pd 1045 23 mycosis mycosi NNS cord-015365-iqdi99pd 1045 24 . . . cord-015365-iqdi99pd 1046 1 Methods method NNS cord-015365-iqdi99pd 1046 2 . . . cord-015365-iqdi99pd 1047 1 We -PRON- PRP cord-015365-iqdi99pd 1047 2 now now RB cord-015365-iqdi99pd 1047 3 report report VBP cord-015365-iqdi99pd 1047 4 for for IN cord-015365-iqdi99pd 1047 5 the the DT cord-015365-iqdi99pd 1047 6 first first JJ cord-015365-iqdi99pd 1047 7 time time NN cord-015365-iqdi99pd 1047 8 a a DT cord-015365-iqdi99pd 1047 9 modified modify VBN cord-015365-iqdi99pd 1047 10 implantation implantation NN cord-015365-iqdi99pd 1047 11 technique technique NN cord-015365-iqdi99pd 1047 12 by by IN cord-015365-iqdi99pd 1047 13 cannulating cannulate VBG cord-015365-iqdi99pd 1047 14 the the DT cord-015365-iqdi99pd 1047 15 right right JJ cord-015365-iqdi99pd 1047 16 atrium atrium NN cord-015365-iqdi99pd 1047 17 in in IN cord-015365-iqdi99pd 1047 18 order order NN cord-015365-iqdi99pd 1047 19 to to TO cord-015365-iqdi99pd 1047 20 reach reach VB cord-015365-iqdi99pd 1047 21 better well JJR cord-015365-iqdi99pd 1047 22 hemodynamics hemodynamic NNS cord-015365-iqdi99pd 1047 23 for for IN cord-015365-iqdi99pd 1047 24 right right JJ cord-015365-iqdi99pd 1047 25 side side NN cord-015365-iqdi99pd 1047 26 support support NN cord-015365-iqdi99pd 1047 27 . . . cord-015365-iqdi99pd 1048 1 To to TO cord-015365-iqdi99pd 1048 2 place place VB cord-015365-iqdi99pd 1048 3 the the DT cord-015365-iqdi99pd 1048 4 HeartWare HeartWare NNP cord-015365-iqdi99pd 1048 5 system system NN cord-015365-iqdi99pd 1048 6 in in IN cord-015365-iqdi99pd 1048 7 the the DT cord-015365-iqdi99pd 1048 8 area area NN cord-015365-iqdi99pd 1048 9 of of IN cord-015365-iqdi99pd 1048 10 the the DT cord-015365-iqdi99pd 1048 11 right right JJ cord-015365-iqdi99pd 1048 12 atrium atrium NN cord-015365-iqdi99pd 1048 13 we -PRON- PRP cord-015365-iqdi99pd 1048 14 have have VBP cord-015365-iqdi99pd 1048 15 created create VBN cord-015365-iqdi99pd 1048 16 a a DT cord-015365-iqdi99pd 1048 17 cavity cavity NN cord-015365-iqdi99pd 1048 18 ( ( -LRB- cord-015365-iqdi99pd 1048 19 8Â8 8â8 CD cord-015365-iqdi99pd 1048 20 cm cm NN cord-015365-iqdi99pd 1048 21 ) ) -RRB- cord-015365-iqdi99pd 1048 22 in in IN cord-015365-iqdi99pd 1048 23 the the DT cord-015365-iqdi99pd 1048 24 right right JJ cord-015365-iqdi99pd 1048 25 - - HYPH cord-015365-iqdi99pd 1048 26 sided sided JJ cord-015365-iqdi99pd 1048 27 pericardium pericardium NN cord-015365-iqdi99pd 1048 28 using use VBG cord-015365-iqdi99pd 1048 29 a a DT cord-015365-iqdi99pd 1048 30 PTFE PTFE NNP cord-015365-iqdi99pd 1048 31 membrane membrane NN cord-015365-iqdi99pd 1048 32 . . . cord-015365-iqdi99pd 1049 1 Results result NNS cord-015365-iqdi99pd 1049 2 . . . cord-015365-iqdi99pd 1050 1 The the DT cord-015365-iqdi99pd 1050 2 design design NN cord-015365-iqdi99pd 1050 3 of of IN cord-015365-iqdi99pd 1050 4 the the DT cord-015365-iqdi99pd 1050 5 HeartWare HeartWare NNP cord-015365-iqdi99pd 1050 6 device device NN cord-015365-iqdi99pd 1050 7 enables enable VBZ cord-015365-iqdi99pd 1050 8 a a DT cord-015365-iqdi99pd 1050 9 quick quick JJ cord-015365-iqdi99pd 1050 10 and and CC cord-015365-iqdi99pd 1050 11 less less RBR cord-015365-iqdi99pd 1050 12 invasive invasive JJ cord-015365-iqdi99pd 1050 13 implantation implantation NN cord-015365-iqdi99pd 1050 14 . . . cord-015365-iqdi99pd 1051 1 The the DT cord-015365-iqdi99pd 1051 2 small small JJ cord-015365-iqdi99pd 1051 3 size size NN cord-015365-iqdi99pd 1051 4 of of IN cord-015365-iqdi99pd 1051 5 the the DT cord-015365-iqdi99pd 1051 6 pump pump NN cord-015365-iqdi99pd 1051 7 allows allow VBZ cord-015365-iqdi99pd 1051 8 for for IN cord-015365-iqdi99pd 1051 9 intrapericardial intrapericardial JJ cord-015365-iqdi99pd 1051 10 placement placement NN cord-015365-iqdi99pd 1051 11 even even RB cord-015365-iqdi99pd 1051 12 in in IN cord-015365-iqdi99pd 1051 13 biventricular biventricular JJ cord-015365-iqdi99pd 1051 14 support support NN cord-015365-iqdi99pd 1051 15 . . . cord-015365-iqdi99pd 1052 1 To to TO cord-015365-iqdi99pd 1052 2 prevent prevent VB cord-015365-iqdi99pd 1052 3 compromise compromise NN cord-015365-iqdi99pd 1052 4 of of IN cord-015365-iqdi99pd 1052 5 the the DT cord-015365-iqdi99pd 1052 6 right right JJ cord-015365-iqdi99pd 1052 7 atrium atrium NN cord-015365-iqdi99pd 1052 8 it -PRON- PRP cord-015365-iqdi99pd 1052 9 is be VBZ cord-015365-iqdi99pd 1052 10 necessary necessary JJ cord-015365-iqdi99pd 1052 11 to to TO cord-015365-iqdi99pd 1052 12 build build VB cord-015365-iqdi99pd 1052 13 a a DT cord-015365-iqdi99pd 1052 14 cavity cavity NN cord-015365-iqdi99pd 1052 15 in in IN cord-015365-iqdi99pd 1052 16 the the DT cord-015365-iqdi99pd 1052 17 pericardium pericardium NN cord-015365-iqdi99pd 1052 18 for for IN cord-015365-iqdi99pd 1052 19 pump pump NN cord-015365-iqdi99pd 1052 20 placement placement NN cord-015365-iqdi99pd 1052 21 . . . cord-015365-iqdi99pd 1053 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1053 2 . . . cord-015365-iqdi99pd 1054 1 Adequate adequate JJ cord-015365-iqdi99pd 1054 2 pump pump NN cord-015365-iqdi99pd 1054 3 flow flow NN cord-015365-iqdi99pd 1054 4 was be VBD cord-015365-iqdi99pd 1054 5 observed observe VBN cord-015365-iqdi99pd 1054 6 during during IN cord-015365-iqdi99pd 1054 7 total total JJ cord-015365-iqdi99pd 1054 8 support support NN cord-015365-iqdi99pd 1054 9 time time NN cord-015365-iqdi99pd 1054 10 . . . cord-015365-iqdi99pd 1055 1 The the DT cord-015365-iqdi99pd 1055 2 presented present VBN cord-015365-iqdi99pd 1055 3 implantation implantation NN cord-015365-iqdi99pd 1055 4 technique technique NN cord-015365-iqdi99pd 1055 5 allows allow VBZ cord-015365-iqdi99pd 1055 6 a a DT cord-015365-iqdi99pd 1055 7 safe safe JJ cord-015365-iqdi99pd 1055 8 and and CC cord-015365-iqdi99pd 1055 9 elegant elegant JJ cord-015365-iqdi99pd 1055 10 bridging bridging NN cord-015365-iqdi99pd 1055 11 - - HYPH cord-015365-iqdi99pd 1055 12 to to IN cord-015365-iqdi99pd 1055 13 - - HYPH cord-015365-iqdi99pd 1055 14 transplant transplant NN cord-015365-iqdi99pd 1055 15 in in IN cord-015365-iqdi99pd 1055 16 Htx Htx NNP cord-015365-iqdi99pd 1055 17 candidates candidate NNS cord-015365-iqdi99pd 1055 18 representing represent VBG cord-015365-iqdi99pd 1055 19 biventricular biventricular JJ cord-015365-iqdi99pd 1055 20 failure failure NN cord-015365-iqdi99pd 1055 21 . . . cord-015365-iqdi99pd 1056 1 Use use NN cord-015365-iqdi99pd 1056 2 of of IN cord-015365-iqdi99pd 1056 3 cardiopulmonary cardiopulmonary JJ cord-015365-iqdi99pd 1056 4 bypass bypass NN cord-015365-iqdi99pd 1056 5 for for IN cord-015365-iqdi99pd 1056 6 lung lung NN cord-015365-iqdi99pd 1056 7 transplantation transplantation NN cord-015365-iqdi99pd 1056 8 : : : cord-015365-iqdi99pd 1056 9 institutional institutional JJ cord-015365-iqdi99pd 1056 10 experience experience NN cord-015365-iqdi99pd 1056 11 Background Background NNP cord-015365-iqdi99pd 1056 12 . . . cord-015365-iqdi99pd 1057 1 The the DT cord-015365-iqdi99pd 1057 2 use use NN cord-015365-iqdi99pd 1057 3 of of IN cord-015365-iqdi99pd 1057 4 cardiopulmonary cardiopulmonary JJ cord-015365-iqdi99pd 1057 5 bypass bypass NN cord-015365-iqdi99pd 1057 6 ( ( -LRB- cord-015365-iqdi99pd 1057 7 CPB CPB NNP cord-015365-iqdi99pd 1057 8 ) ) -RRB- cord-015365-iqdi99pd 1057 9 for for IN cord-015365-iqdi99pd 1057 10 lung lung NN cord-015365-iqdi99pd 1057 11 transplantation transplantation NN cord-015365-iqdi99pd 1057 12 is be VBZ cord-015365-iqdi99pd 1057 13 still still RB cord-015365-iqdi99pd 1057 14 judged judge VBN cord-015365-iqdi99pd 1057 15 controversial controversial JJ cord-015365-iqdi99pd 1057 16 . . . cord-015365-iqdi99pd 1058 1 However however RB cord-015365-iqdi99pd 1058 2 , , , cord-015365-iqdi99pd 1058 3 in in IN cord-015365-iqdi99pd 1058 4 30 30 CD cord-015365-iqdi99pd 1058 5 % % NN cord-015365-iqdi99pd 1058 6 of of IN cord-015365-iqdi99pd 1058 7 lung lung NN cord-015365-iqdi99pd 1058 8 transplantations transplantation NNS cord-015365-iqdi99pd 1058 9 CPB CPB NNP cord-015365-iqdi99pd 1058 10 support support VBP cord-015365-iqdi99pd 1058 11 during during IN cord-015365-iqdi99pd 1058 12 the the DT cord-015365-iqdi99pd 1058 13 surgical surgical JJ cord-015365-iqdi99pd 1058 14 procedure procedure NN cord-015365-iqdi99pd 1058 15 is be VBZ cord-015365-iqdi99pd 1058 16 required require VBN cord-015365-iqdi99pd 1058 17 for for IN cord-015365-iqdi99pd 1058 18 hemodynamic hemodynamic JJ cord-015365-iqdi99pd 1058 19 and/or and/or CC cord-015365-iqdi99pd 1058 20 respiratory respiratory JJ cord-015365-iqdi99pd 1058 21 instability instability NN cord-015365-iqdi99pd 1058 22 or or CC cord-015365-iqdi99pd 1058 23 for for IN cord-015365-iqdi99pd 1058 24 repair repair NN cord-015365-iqdi99pd 1058 25 of of IN cord-015365-iqdi99pd 1058 26 intracardiac intracardiac NNP cord-015365-iqdi99pd 1058 27 pathologies pathology NNS cord-015365-iqdi99pd 1058 28 . . . cord-015365-iqdi99pd 1059 1 This this DT cord-015365-iqdi99pd 1059 2 study study NN cord-015365-iqdi99pd 1059 3 aimed aim VBD cord-015365-iqdi99pd 1059 4 to to TO cord-015365-iqdi99pd 1059 5 determine determine VB cord-015365-iqdi99pd 1059 6 if if IN cord-015365-iqdi99pd 1059 7 the the DT cord-015365-iqdi99pd 1059 8 use use NN cord-015365-iqdi99pd 1059 9 of of IN cord-015365-iqdi99pd 1059 10 CPB CPB NNP cord-015365-iqdi99pd 1059 11 has have VBZ cord-015365-iqdi99pd 1059 12 an an DT cord-015365-iqdi99pd 1059 13 effect effect NN cord-015365-iqdi99pd 1059 14 on on IN cord-015365-iqdi99pd 1059 15 survival survival NN cord-015365-iqdi99pd 1059 16 . . . cord-015365-iqdi99pd 1060 1 Methods method NNS cord-015365-iqdi99pd 1060 2 . . . cord-015365-iqdi99pd 1061 1 A a DT cord-015365-iqdi99pd 1061 2 retrospective retrospective JJ cord-015365-iqdi99pd 1061 3 review review NN cord-015365-iqdi99pd 1061 4 of of IN cord-015365-iqdi99pd 1061 5 190 190 CD cord-015365-iqdi99pd 1061 6 lung lung NN cord-015365-iqdi99pd 1061 7 transplants transplant NNS cord-015365-iqdi99pd 1061 8 in in IN cord-015365-iqdi99pd 1061 9 180 180 CD cord-015365-iqdi99pd 1061 10 patients patient NNS cord-015365-iqdi99pd 1061 11 ( ( -LRB- cord-015365-iqdi99pd 1061 12 mean mean VB cord-015365-iqdi99pd 1061 13 age age NN cord-015365-iqdi99pd 1061 14 : : : cord-015365-iqdi99pd 1061 15 59 59 CD cord-015365-iqdi99pd 1061 16 years year NNS cord-015365-iqdi99pd 1061 17 ) ) -RRB- cord-015365-iqdi99pd 1061 18 with with IN cord-015365-iqdi99pd 1061 19 different different JJ cord-015365-iqdi99pd 1061 20 lung lung NN cord-015365-iqdi99pd 1061 21 pathologies pathology NNS cord-015365-iqdi99pd 1061 22 who who WP cord-015365-iqdi99pd 1061 23 underwent undergo VBD cord-015365-iqdi99pd 1061 24 bilateral bilateral JJ cord-015365-iqdi99pd 1061 25 or or CC cord-015365-iqdi99pd 1061 26 single single JJ cord-015365-iqdi99pd 1061 27 lung lung NN cord-015365-iqdi99pd 1061 28 transplantation transplantation NN cord-015365-iqdi99pd 1061 29 between between IN cord-015365-iqdi99pd 1061 30 November November NNP cord-015365-iqdi99pd 1061 31 1993 1993 CD cord-015365-iqdi99pd 1061 32 and and CC cord-015365-iqdi99pd 1061 33 June June NNP cord-015365-iqdi99pd 1061 34 2011 2011 CD cord-015365-iqdi99pd 1061 35 was be VBD cord-015365-iqdi99pd 1061 36 performed perform VBN cord-015365-iqdi99pd 1061 37 . . . cord-015365-iqdi99pd 1062 1 75 75 CD cord-015365-iqdi99pd 1062 2 patients patient NNS cord-015365-iqdi99pd 1062 3 ( ( -LRB- cord-015365-iqdi99pd 1062 4 39.4 39.4 CD cord-015365-iqdi99pd 1062 5 % % NN cord-015365-iqdi99pd 1062 6 ) ) -RRB- cord-015365-iqdi99pd 1062 7 in in IN cord-015365-iqdi99pd 1062 8 whom whom WP cord-015365-iqdi99pd 1062 9 elective elective JJ cord-015365-iqdi99pd 1062 10 as as RB cord-015365-iqdi99pd 1062 11 well well RB cord-015365-iqdi99pd 1062 12 as as IN cord-015365-iqdi99pd 1062 13 emergent emergent JJ cord-015365-iqdi99pd 1062 14 CPB CPB NNP cord-015365-iqdi99pd 1062 15 was be VBD cord-015365-iqdi99pd 1062 16 necessary necessary JJ cord-015365-iqdi99pd 1062 17 were be VBD cord-015365-iqdi99pd 1062 18 compared compare VBN cord-015365-iqdi99pd 1062 19 with with IN cord-015365-iqdi99pd 1062 20 115 115 CD cord-015365-iqdi99pd 1062 21 cases case NNS cord-015365-iqdi99pd 1062 22 ( ( -LRB- cord-015365-iqdi99pd 1062 23 60.6 60.6 CD cord-015365-iqdi99pd 1062 24 % % NN cord-015365-iqdi99pd 1062 25 ) ) -RRB- cord-015365-iqdi99pd 1062 26 without without IN cord-015365-iqdi99pd 1062 27 CPB CPB NNP cord-015365-iqdi99pd 1062 28 . . . cord-015365-iqdi99pd 1063 1 Results result NNS cord-015365-iqdi99pd 1063 2 . . . cord-015365-iqdi99pd 1064 1 The the DT cord-015365-iqdi99pd 1064 2 indications indication NNS cord-015365-iqdi99pd 1064 3 for for IN cord-015365-iqdi99pd 1064 4 lung lung NN cord-015365-iqdi99pd 1064 5 transplantation transplantation NN cord-015365-iqdi99pd 1064 6 were be VBD cord-015365-iqdi99pd 1064 7 chronic chronic JJ cord-015365-iqdi99pd 1064 8 obstructive obstructive JJ cord-015365-iqdi99pd 1064 9 pulmonary pulmonary JJ cord-015365-iqdi99pd 1064 10 disease disease NN cord-015365-iqdi99pd 1064 11 ( ( -LRB- cord-015365-iqdi99pd 1064 12 COPD COPD NNP cord-015365-iqdi99pd 1064 13 , , , cord-015365-iqdi99pd 1064 14 n n NN cord-015365-iqdi99pd 1064 15 ¼ ¼ NNP cord-015365-iqdi99pd 1064 16 111 111 CD cord-015365-iqdi99pd 1064 17 ) ) -RRB- cord-015365-iqdi99pd 1064 18 , , , cord-015365-iqdi99pd 1064 19 fibrosis fibrosis NN cord-015365-iqdi99pd 1064 20 ( ( -LRB- cord-015365-iqdi99pd 1064 21 n n NNP cord-015365-iqdi99pd 1064 22 ¼ ¼ NNP cord-015365-iqdi99pd 1064 23 32 32 CD cord-015365-iqdi99pd 1064 24 ) ) -RRB- cord-015365-iqdi99pd 1064 25 , , . cord-015365-iqdi99pd 1065 1 alpha-1 alpha-1 NN cord-015365-iqdi99pd 1065 2 antitrypsin antitrypsin NN cord-015365-iqdi99pd 1065 3 deficiency deficiency NN cord-015365-iqdi99pd 1065 4 emphysema emphysema NN cord-015365-iqdi99pd 1065 5 ( ( -LRB- cord-015365-iqdi99pd 1065 6 n n NNP cord-015365-iqdi99pd 1065 7 ¼ ¼ NNP cord-015365-iqdi99pd 1065 8 13 13 CD cord-015365-iqdi99pd 1065 9 ) ) -RRB- cord-015365-iqdi99pd 1065 10 and and CC cord-015365-iqdi99pd 1065 11 others other NNS cord-015365-iqdi99pd 1065 12 ( ( -LRB- cord-015365-iqdi99pd 1065 13 n n CC cord-015365-iqdi99pd 1065 14 ¼ ¼ NNP cord-015365-iqdi99pd 1065 15 34 34 CD cord-015365-iqdi99pd 1065 16 ) ) -RRB- cord-015365-iqdi99pd 1065 17 . . . cord-015365-iqdi99pd 1066 1 The the DT cord-015365-iqdi99pd 1066 2 follow follow NN cord-015365-iqdi99pd 1066 3 up up RP cord-015365-iqdi99pd 1066 4 period period NN cord-015365-iqdi99pd 1066 5 ranged range VBD cord-015365-iqdi99pd 1066 6 from from IN cord-015365-iqdi99pd 1066 7 2 2 CD cord-015365-iqdi99pd 1066 8 days day NNS cord-015365-iqdi99pd 1066 9 to to IN cord-015365-iqdi99pd 1066 10 14 14 CD cord-015365-iqdi99pd 1066 11 years year NNS cord-015365-iqdi99pd 1066 12 . . . cord-015365-iqdi99pd 1067 1 Total total JJ cord-015365-iqdi99pd 1067 2 mean mean JJ cord-015365-iqdi99pd 1067 3 survival survival NN cord-015365-iqdi99pd 1067 4 was be VBD cord-015365-iqdi99pd 1067 5 980 980 CD cord-015365-iqdi99pd 1067 6 days day NNS cord-015365-iqdi99pd 1067 7 ( ( -LRB- cord-015365-iqdi99pd 1067 8 range range NN cord-015365-iqdi99pd 1067 9 0 0 CD cord-015365-iqdi99pd 1067 10 to to IN cord-015365-iqdi99pd 1067 11 5276 5276 CD cord-015365-iqdi99pd 1067 12 days day NNS cord-015365-iqdi99pd 1067 13 ) ) -RRB- cord-015365-iqdi99pd 1067 14 . . . cord-015365-iqdi99pd 1068 1 There there EX cord-015365-iqdi99pd 1068 2 was be VBD cord-015365-iqdi99pd 1068 3 no no DT cord-015365-iqdi99pd 1068 4 significant significant JJ cord-015365-iqdi99pd 1068 5 difference difference NN cord-015365-iqdi99pd 1068 6 in in IN cord-015365-iqdi99pd 1068 7 mortality mortality NN cord-015365-iqdi99pd 1068 8 between between IN cord-015365-iqdi99pd 1068 9 the the DT cord-015365-iqdi99pd 1068 10 CPB CPB NNP cord-015365-iqdi99pd 1068 11 and and CC cord-015365-iqdi99pd 1068 12 the the DT cord-015365-iqdi99pd 1068 13 control control NN cord-015365-iqdi99pd 1068 14 group group NN cord-015365-iqdi99pd 1068 15 ( ( -LRB- cord-015365-iqdi99pd 1068 16 p p NN cord-015365-iqdi99pd 1068 17 ¼ ¼ CD cord-015365-iqdi99pd 1068 18 0.723 0.723 CD cord-015365-iqdi99pd 1068 19 ) ) -RRB- cord-015365-iqdi99pd 1068 20 . . . cord-015365-iqdi99pd 1069 1 The the DT cord-015365-iqdi99pd 1069 2 comparison comparison NN cord-015365-iqdi99pd 1069 3 between between IN cord-015365-iqdi99pd 1069 4 COPD COPD NNP cord-015365-iqdi99pd 1069 5 patients patient NNS cord-015365-iqdi99pd 1069 6 and and CC cord-015365-iqdi99pd 1069 7 other other JJ cord-015365-iqdi99pd 1069 8 indications indication NNS cord-015365-iqdi99pd 1069 9 for for IN cord-015365-iqdi99pd 1069 10 lung lung NN cord-015365-iqdi99pd 1069 11 transplantation transplantation NN cord-015365-iqdi99pd 1069 12 also also RB cord-015365-iqdi99pd 1069 13 revealed reveal VBD cord-015365-iqdi99pd 1069 14 no no DT cord-015365-iqdi99pd 1069 15 significant significant JJ cord-015365-iqdi99pd 1069 16 difference difference NN cord-015365-iqdi99pd 1069 17 in in IN cord-015365-iqdi99pd 1069 18 survival survival NN cord-015365-iqdi99pd 1069 19 ( ( -LRB- cord-015365-iqdi99pd 1069 20 p p NN cord-015365-iqdi99pd 1069 21 ¼ ¼ CD cord-015365-iqdi99pd 1069 22 0.11 0.11 CD cord-015365-iqdi99pd 1069 23 ) ) -RRB- cord-015365-iqdi99pd 1069 24 . . . cord-015365-iqdi99pd 1070 1 There there EX cord-015365-iqdi99pd 1070 2 was be VBD cord-015365-iqdi99pd 1070 3 also also RB cord-015365-iqdi99pd 1070 4 no no DT cord-015365-iqdi99pd 1070 5 difference difference NN cord-015365-iqdi99pd 1070 6 between between IN cord-015365-iqdi99pd 1070 7 COPD COPD NNP cord-015365-iqdi99pd 1070 8 patients patient NNS cord-015365-iqdi99pd 1070 9 in in IN cord-015365-iqdi99pd 1070 10 whom whom WP cord-015365-iqdi99pd 1070 11 surgery surgery NN cord-015365-iqdi99pd 1070 12 was be VBD cord-015365-iqdi99pd 1070 13 performed perform VBN cord-015365-iqdi99pd 1070 14 with with IN cord-015365-iqdi99pd 1070 15 CPB CPB NNP cord-015365-iqdi99pd 1070 16 or or CC cord-015365-iqdi99pd 1070 17 without without IN cord-015365-iqdi99pd 1070 18 ( ( -LRB- cord-015365-iqdi99pd 1070 19 p p NN cord-015365-iqdi99pd 1070 20 ¼ ¼ NNP cord-015365-iqdi99pd 1070 21 0.676 0.676 CD cord-015365-iqdi99pd 1070 22 ) ) -RRB- cord-015365-iqdi99pd 1070 23 . . . cord-015365-iqdi99pd 1071 1 Survival survival NN cord-015365-iqdi99pd 1071 2 rates rate NNS cord-015365-iqdi99pd 1071 3 in in IN cord-015365-iqdi99pd 1071 4 patients patient NNS cord-015365-iqdi99pd 1071 5 over over IN cord-015365-iqdi99pd 1071 6 60 60 CD cord-015365-iqdi99pd 1071 7 years year NNS cord-015365-iqdi99pd 1071 8 were be VBD cord-015365-iqdi99pd 1071 9 similar similar JJ cord-015365-iqdi99pd 1071 10 to to IN cord-015365-iqdi99pd 1071 11 patients patient NNS cord-015365-iqdi99pd 1071 12 under under IN cord-015365-iqdi99pd 1071 13 60 60 CD cord-015365-iqdi99pd 1071 14 independent independent JJ cord-015365-iqdi99pd 1071 15 from from IN cord-015365-iqdi99pd 1071 16 the the DT cord-015365-iqdi99pd 1071 17 use use NN cord-015365-iqdi99pd 1071 18 of of IN cord-015365-iqdi99pd 1071 19 CPB CPB NNP cord-015365-iqdi99pd 1071 20 ( ( -LRB- cord-015365-iqdi99pd 1071 21 p p NN cord-015365-iqdi99pd 1071 22 ¼ ¼ NNP cord-015365-iqdi99pd 1071 23 0.676 0.676 CD cord-015365-iqdi99pd 1071 24 ) ) -RRB- cord-015365-iqdi99pd 1071 25 . . . cord-015365-iqdi99pd 1072 1 There there EX cord-015365-iqdi99pd 1072 2 was be VBD cord-015365-iqdi99pd 1072 3 also also RB cord-015365-iqdi99pd 1072 4 no no DT cord-015365-iqdi99pd 1072 5 significant significant JJ cord-015365-iqdi99pd 1072 6 difference difference NN cord-015365-iqdi99pd 1072 7 in in IN cord-015365-iqdi99pd 1072 8 the the DT cord-015365-iqdi99pd 1072 9 usage usage NN cord-015365-iqdi99pd 1072 10 of of IN cord-015365-iqdi99pd 1072 11 CPB CPB NNP cord-015365-iqdi99pd 1072 12 between between IN cord-015365-iqdi99pd 1072 13 single single JJ cord-015365-iqdi99pd 1072 14 versus versus IN cord-015365-iqdi99pd 1072 15 bilateral bilateral JJ cord-015365-iqdi99pd 1072 16 lung lung NN cord-015365-iqdi99pd 1072 17 transplantation transplantation NN cord-015365-iqdi99pd 1072 18 ( ( -LRB- cord-015365-iqdi99pd 1072 19 p p NN cord-015365-iqdi99pd 1072 20 ¼ ¼ CD cord-015365-iqdi99pd 1072 21 0.44 0.44 CD cord-015365-iqdi99pd 1072 22 ) ) -RRB- cord-015365-iqdi99pd 1072 23 . . . cord-015365-iqdi99pd 1073 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1073 2 . . . cord-015365-iqdi99pd 1074 1 This this DT cord-015365-iqdi99pd 1074 2 study study NN cord-015365-iqdi99pd 1074 3 revealed reveal VBD cord-015365-iqdi99pd 1074 4 no no DT cord-015365-iqdi99pd 1074 5 increase increase NN cord-015365-iqdi99pd 1074 6 in in IN cord-015365-iqdi99pd 1074 7 mortality mortality NN cord-015365-iqdi99pd 1074 8 after after IN cord-015365-iqdi99pd 1074 9 lung lung NN cord-015365-iqdi99pd 1074 10 transplantation transplantation NN cord-015365-iqdi99pd 1074 11 when when WRB cord-015365-iqdi99pd 1074 12 cardiopulmonary cardiopulmonary JJ cord-015365-iqdi99pd 1074 13 bypass bypass NN cord-015365-iqdi99pd 1074 14 was be VBD cord-015365-iqdi99pd 1074 15 required require VBN cord-015365-iqdi99pd 1074 16 . . . cord-015365-iqdi99pd 1075 1 When when WRB cord-015365-iqdi99pd 1075 2 CPB CPB NNP cord-015365-iqdi99pd 1075 3 appears appear VBZ cord-015365-iqdi99pd 1075 4 necessary necessary JJ cord-015365-iqdi99pd 1075 5 it -PRON- PRP cord-015365-iqdi99pd 1075 6 should should MD cord-015365-iqdi99pd 1075 7 be be VB cord-015365-iqdi99pd 1075 8 employed employ VBN cord-015365-iqdi99pd 1075 9 right right RB cord-015365-iqdi99pd 1075 10 away away RB cord-015365-iqdi99pd 1075 11 to to TO cord-015365-iqdi99pd 1075 12 avoid avoid VB cord-015365-iqdi99pd 1075 13 hemodynamic hemodynamic JJ cord-015365-iqdi99pd 1075 14 compromise compromise NN cord-015365-iqdi99pd 1075 15 or or CC cord-015365-iqdi99pd 1075 16 severe severe JJ cord-015365-iqdi99pd 1075 17 reperfusion reperfusion NN cord-015365-iqdi99pd 1075 18 edema edema NN cord-015365-iqdi99pd 1075 19 due due IN cord-015365-iqdi99pd 1075 20 to to IN cord-015365-iqdi99pd 1075 21 unacceptable unacceptable JJ cord-015365-iqdi99pd 1075 22 pulmonary pulmonary JJ cord-015365-iqdi99pd 1075 23 arterial arterial JJ cord-015365-iqdi99pd 1075 24 pressures pressure NNS cord-015365-iqdi99pd 1075 25 . . . cord-015365-iqdi99pd 1076 1 Erfahrungsbericht Erfahrungsbericht NNP cord-015365-iqdi99pd 1076 2 aus aus NNP cord-015365-iqdi99pd 1076 3 dem dem NNP cord-015365-iqdi99pd 1076 4 Deutschen Deutschen NNP cord-015365-iqdi99pd 1076 5 Herzzentrum Herzzentrum NNP cord-015365-iqdi99pd 1076 6 Berlin Berlin NNP cord-015365-iqdi99pd 1076 7 _SP cord-015365-iqdi99pd 1077 1 Successful successful JJ cord-015365-iqdi99pd 1077 2 bridging bridge VBG cord-015365-iqdi99pd 1077 3 to to IN cord-015365-iqdi99pd 1077 4 heart heart NN cord-015365-iqdi99pd 1077 5 transplantation transplantation NN cord-015365-iqdi99pd 1077 6 using use VBG cord-015365-iqdi99pd 1077 7 the the DT cord-015365-iqdi99pd 1077 8 Levitronix Levitronix NNP cord-015365-iqdi99pd 1077 9 CentriMag CentriMag NNP cord-015365-iqdi99pd 1077 10 system system NN cord-015365-iqdi99pd 1077 11 and and CC cord-015365-iqdi99pd 1077 12 DuraHeart DuraHeart NNP cord-015365-iqdi99pd 1077 13 LVAD LVAD NNP cord-015365-iqdi99pd 1077 14 in in IN cord-015365-iqdi99pd 1077 15 a a DT cord-015365-iqdi99pd 1077 16 patient patient NN cord-015365-iqdi99pd 1077 17 with with IN cord-015365-iqdi99pd 1077 18 resuscitation resuscitation NN cord-015365-iqdi99pd 1077 19 related relate VBN cord-015365-iqdi99pd 1077 20 liver liver NN cord-015365-iqdi99pd 1077 21 injury injury NN cord-015365-iqdi99pd 1077 22 N. N. NNP cord-015365-iqdi99pd 1077 23 Reiss Reiss NNP cord-015365-iqdi99pd 1077 24 1 1 CD cord-015365-iqdi99pd 1077 25 , , , cord-015365-iqdi99pd 1077 26 L. L. NNP cord-015365-iqdi99pd 1077 27 Kizner Kizner NNP cord-015365-iqdi99pd 1077 28 2 2 CD cord-015365-iqdi99pd 1077 29 , , , cord-015365-iqdi99pd 1077 30 U. U. NNP cord-015365-iqdi99pd 1077 31 Schulz Schulz NNP cord-015365-iqdi99pd 1078 1 2 2 LS cord-015365-iqdi99pd 1078 2 1 1 CD cord-015365-iqdi99pd 1078 3 Department Department NNP cord-015365-iqdi99pd 1078 4 of of IN cord-015365-iqdi99pd 1078 5 Cardiac Cardiac NNP cord-015365-iqdi99pd 1078 6 Surgery Surgery NNP cord-015365-iqdi99pd 1078 7 Heidelberg Heidelberg NNP cord-015365-iqdi99pd 1078 8 , , , cord-015365-iqdi99pd 1078 9 Universitätsklinikum Universitätsklinikum NNP cord-015365-iqdi99pd 1078 10 Heidelberg Heidelberg NNP cord-015365-iqdi99pd 1078 11 , , , cord-015365-iqdi99pd 1078 12 Germany Germany NNP cord-015365-iqdi99pd 1078 13 ; ; : cord-015365-iqdi99pd 1078 14 2 2 CD cord-015365-iqdi99pd 1078 15 Heart Heart NNP cord-015365-iqdi99pd 1078 16 Center Center NNP cord-015365-iqdi99pd 1078 17 North North NNP cord-015365-iqdi99pd 1078 18 Rhine Rhine NNP cord-015365-iqdi99pd 1078 19 - - HYPH cord-015365-iqdi99pd 1078 20 Westphalia Westphalia NNP cord-015365-iqdi99pd 1078 21 , , , cord-015365-iqdi99pd 1078 22 Ruhr Ruhr NNP cord-015365-iqdi99pd 1078 23 - - HYPH cord-015365-iqdi99pd 1078 24 University University NNP cord-015365-iqdi99pd 1078 25 of of IN cord-015365-iqdi99pd 1078 26 Bochum Bochum NNP cord-015365-iqdi99pd 1078 27 , , , cord-015365-iqdi99pd 1078 28 Bad Bad NNP cord-015365-iqdi99pd 1078 29 Oeynhausen Oeynhausen NNP cord-015365-iqdi99pd 1078 30 , , , cord-015365-iqdi99pd 1078 31 Germany Germany NNP cord-015365-iqdi99pd 1078 32 Background Background NNP cord-015365-iqdi99pd 1078 33 . . . cord-015365-iqdi99pd 1079 1 Mortality mortality NN cord-015365-iqdi99pd 1079 2 rates rate NNS cord-015365-iqdi99pd 1079 3 from from IN cord-015365-iqdi99pd 1079 4 cardiogenic cardiogenic JJ cord-015365-iqdi99pd 1079 5 shock shock NN cord-015365-iqdi99pd 1079 6 after after IN cord-015365-iqdi99pd 1079 7 acute acute JJ cord-015365-iqdi99pd 1079 8 myocardial myocardial JJ cord-015365-iqdi99pd 1079 9 infarction infarction NN cord-015365-iqdi99pd 1079 10 remain remain VBP cord-015365-iqdi99pd 1079 11 extremely extremely RB cord-015365-iqdi99pd 1079 12 high high JJ cord-015365-iqdi99pd 1079 13 . . . cord-015365-iqdi99pd 1080 1 Efforts effort NNS cord-015365-iqdi99pd 1080 2 have have VBP cord-015365-iqdi99pd 1080 3 been be VBN cord-015365-iqdi99pd 1080 4 made make VBN cord-015365-iqdi99pd 1080 5 to to TO cord-015365-iqdi99pd 1080 6 develop develop VB cord-015365-iqdi99pd 1080 7 ventricular ventricular JJ cord-015365-iqdi99pd 1080 8 assist assist VB cord-015365-iqdi99pd 1080 9 devices device NNS cord-015365-iqdi99pd 1080 10 capable capable JJ cord-015365-iqdi99pd 1080 11 of of IN cord-015365-iqdi99pd 1080 12 providing provide VBG cord-015365-iqdi99pd 1080 13 complete complete JJ cord-015365-iqdi99pd 1080 14 hemodynamic hemodynamic JJ cord-015365-iqdi99pd 1080 15 support support NN cord-015365-iqdi99pd 1080 16 in in IN cord-015365-iqdi99pd 1080 17 this this DT cord-015365-iqdi99pd 1080 18 situation situation NN cord-015365-iqdi99pd 1080 19 . . . cord-015365-iqdi99pd 1081 1 Mechanical mechanical JJ cord-015365-iqdi99pd 1081 2 circulatory circulatory JJ cord-015365-iqdi99pd 1081 3 assistance assistance NN cord-015365-iqdi99pd 1081 4 represents represent VBZ cord-015365-iqdi99pd 1081 5 an an DT cord-015365-iqdi99pd 1081 6 evident evident JJ cord-015365-iqdi99pd 1081 7 problem problem NN cord-015365-iqdi99pd 1081 8 when when WRB cord-015365-iqdi99pd 1081 9 bleeding bleed VBG cord-015365-iqdi99pd 1081 10 complications complication NNS cord-015365-iqdi99pd 1081 11 occur occur VBP cord-015365-iqdi99pd 1081 12 . . . cord-015365-iqdi99pd 1082 1 We -PRON- PRP cord-015365-iqdi99pd 1082 2 report report VBP cord-015365-iqdi99pd 1082 3 a a DT cord-015365-iqdi99pd 1082 4 very very RB cord-015365-iqdi99pd 1082 5 rare rare JJ cord-015365-iqdi99pd 1082 6 case case NN cord-015365-iqdi99pd 1082 7 of of IN cord-015365-iqdi99pd 1082 8 successful successful JJ cord-015365-iqdi99pd 1082 9 bridging bridging NN cord-015365-iqdi99pd 1082 10 to to IN cord-015365-iqdi99pd 1082 11 heart heart NN cord-015365-iqdi99pd 1082 12 transplantation transplantation NN cord-015365-iqdi99pd 1082 13 despite despite IN cord-015365-iqdi99pd 1082 14 severe severe JJ cord-015365-iqdi99pd 1082 15 resuscitation resuscitation NN cord-015365-iqdi99pd 1082 16 related relate VBD cord-015365-iqdi99pd 1082 17 liver liver NN cord-015365-iqdi99pd 1082 18 injury injury NN cord-015365-iqdi99pd 1082 19 . . . cord-015365-iqdi99pd 1083 1 Methods method NNS cord-015365-iqdi99pd 1083 2 . . . cord-015365-iqdi99pd 1084 1 A a DT cord-015365-iqdi99pd 1084 2 54-year 54-year JJ cord-015365-iqdi99pd 1084 3 - - HYPH cord-015365-iqdi99pd 1084 4 old old JJ cord-015365-iqdi99pd 1084 5 male male JJ cord-015365-iqdi99pd 1084 6 patient patient NN cord-015365-iqdi99pd 1084 7 underwent undergo VBD cord-015365-iqdi99pd 1084 8 failed failed JJ cord-015365-iqdi99pd 1084 9 percutaneous percutaneous JJ cord-015365-iqdi99pd 1084 10 coronary coronary NN cord-015365-iqdi99pd 1084 11 intervention intervention NN cord-015365-iqdi99pd 1084 12 of of IN cord-015365-iqdi99pd 1084 13 LAD LAD NNP cord-015365-iqdi99pd 1084 14 with with IN cord-015365-iqdi99pd 1084 15 consecutive consecutive JJ cord-015365-iqdi99pd 1084 16 prolonged prolong VBN cord-015365-iqdi99pd 1084 17 resuscitation resuscitation NN cord-015365-iqdi99pd 1084 18 . . . cord-015365-iqdi99pd 1085 1 A a DT cord-015365-iqdi99pd 1085 2 Levitronix Levitronix NNP cord-015365-iqdi99pd 1085 3 CentriMag CentriMag NNP cord-015365-iqdi99pd 1085 4 system system NN cord-015365-iqdi99pd 1085 5 was be VBD cord-015365-iqdi99pd 1085 6 implanted implant VBN cord-015365-iqdi99pd 1085 7 via via IN cord-015365-iqdi99pd 1085 8 femoral femoral JJ cord-015365-iqdi99pd 1085 9 vessels vessel NNS cord-015365-iqdi99pd 1085 10 for for IN cord-015365-iqdi99pd 1085 11 rapid rapid JJ cord-015365-iqdi99pd 1085 12 hemodynamic hemodynamic JJ cord-015365-iqdi99pd 1085 13 stabilization stabilization NN cord-015365-iqdi99pd 1085 14 . . . cord-015365-iqdi99pd 1086 1 An an DT cord-015365-iqdi99pd 1086 2 acute acute JJ cord-015365-iqdi99pd 1086 3 laparotomy laparotomy NN cord-015365-iqdi99pd 1086 4 was be VBD cord-015365-iqdi99pd 1086 5 necessary necessary JJ cord-015365-iqdi99pd 1086 6 because because IN cord-015365-iqdi99pd 1086 7 of of IN cord-015365-iqdi99pd 1086 8 severe severe JJ cord-015365-iqdi99pd 1086 9 injury injury NN cord-015365-iqdi99pd 1086 10 of of IN cord-015365-iqdi99pd 1086 11 the the DT cord-015365-iqdi99pd 1086 12 left left JJ cord-015365-iqdi99pd 1086 13 lobe lobe NN cord-015365-iqdi99pd 1086 14 of of IN cord-015365-iqdi99pd 1086 15 the the DT cord-015365-iqdi99pd 1086 16 liver liver NN cord-015365-iqdi99pd 1086 17 . . . cord-015365-iqdi99pd 1087 1 During during IN cord-015365-iqdi99pd 1087 2 laparotomy laparotomy NN cord-015365-iqdi99pd 1087 3 the the DT cord-015365-iqdi99pd 1087 4 abdominal abdominal JJ cord-015365-iqdi99pd 1087 5 cave cave NN cord-015365-iqdi99pd 1087 6 was be VBD cord-015365-iqdi99pd 1087 7 tamponated tamponate VBN cord-015365-iqdi99pd 1087 8 by by IN cord-015365-iqdi99pd 1087 9 multiple multiple JJ cord-015365-iqdi99pd 1087 10 compresses compress NNS cord-015365-iqdi99pd 1087 11 . . . cord-015365-iqdi99pd 1088 1 Three three CD cord-015365-iqdi99pd 1088 2 times time NNS cord-015365-iqdi99pd 1088 3 relaparotomy relaparotomy NNP cord-015365-iqdi99pd 1088 4 was be VBD cord-015365-iqdi99pd 1088 5 necessary necessary JJ cord-015365-iqdi99pd 1088 6 to to TO cord-015365-iqdi99pd 1088 7 achieve achieve VB cord-015365-iqdi99pd 1088 8 final final JJ cord-015365-iqdi99pd 1088 9 hemostasis hemostasis NN cord-015365-iqdi99pd 1088 10 . . . cord-015365-iqdi99pd 1089 1 After after IN cord-015365-iqdi99pd 1089 2 four four CD cord-015365-iqdi99pd 1089 3 weeks week NNS cord-015365-iqdi99pd 1089 4 of of IN cord-015365-iqdi99pd 1089 5 Levitronix Levitronix NNP cord-015365-iqdi99pd 1089 6 CentriMag CentriMag NNP cord-015365-iqdi99pd 1089 7 support support VBP cord-015365-iqdi99pd 1089 8 the the DT cord-015365-iqdi99pd 1089 9 system system NN cord-015365-iqdi99pd 1089 10 was be VBD cord-015365-iqdi99pd 1089 11 switched switch VBN cord-015365-iqdi99pd 1089 12 to to IN cord-015365-iqdi99pd 1089 13 DuraHeart DuraHeart NNP cord-015365-iqdi99pd 1089 14 LVAD LVAD NNP cord-015365-iqdi99pd 1089 15 for for IN cord-015365-iqdi99pd 1089 16 long long JJ cord-015365-iqdi99pd 1089 17 - - HYPH cord-015365-iqdi99pd 1089 18 term term NN cord-015365-iqdi99pd 1089 19 assistance assistance NN cord-015365-iqdi99pd 1089 20 as as IN cord-015365-iqdi99pd 1089 21 a a DT cord-015365-iqdi99pd 1089 22 bridge bridge NN cord-015365-iqdi99pd 1089 23 - - HYPH cord-015365-iqdi99pd 1089 24 to to IN cord-015365-iqdi99pd 1089 25 - - HYPH cord-015365-iqdi99pd 1089 26 transplant transplant NN cord-015365-iqdi99pd 1089 27 . . . cord-015365-iqdi99pd 1090 1 Results result NNS cord-015365-iqdi99pd 1090 2 . . . cord-015365-iqdi99pd 1091 1 Successful successful JJ cord-015365-iqdi99pd 1091 2 heart heart NN cord-015365-iqdi99pd 1091 3 transplantation transplantation NN cord-015365-iqdi99pd 1091 4 was be VBD cord-015365-iqdi99pd 1091 5 performed perform VBN cord-015365-iqdi99pd 1091 6 after after IN cord-015365-iqdi99pd 1091 7 complete complete JJ cord-015365-iqdi99pd 1091 8 recovery recovery NN cord-015365-iqdi99pd 1091 9 and and CC cord-015365-iqdi99pd 1091 10 mobilization mobilization NN cord-015365-iqdi99pd 1091 11 of of IN cord-015365-iqdi99pd 1091 12 the the DT cord-015365-iqdi99pd 1091 13 patient patient JJ cord-015365-iqdi99pd 1091 14 320 320 CD cord-015365-iqdi99pd 1091 15 days day NNS cord-015365-iqdi99pd 1091 16 after after IN cord-015365-iqdi99pd 1091 17 the the DT cord-015365-iqdi99pd 1091 18 disastrous disastrous JJ cord-015365-iqdi99pd 1091 19 and and CC cord-015365-iqdi99pd 1091 20 hopeless hopeless JJ cord-015365-iqdi99pd 1091 21 initial initial JJ cord-015365-iqdi99pd 1091 22 situation situation NN cord-015365-iqdi99pd 1091 23 . . . cord-015365-iqdi99pd 1092 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1092 2 . . . cord-015365-iqdi99pd 1093 1 The the DT cord-015365-iqdi99pd 1093 2 present present JJ cord-015365-iqdi99pd 1093 3 case case NN cord-015365-iqdi99pd 1093 4 demonstrates demonstrate VBZ cord-015365-iqdi99pd 1093 5 that that IN cord-015365-iqdi99pd 1093 6 successful successful JJ cord-015365-iqdi99pd 1093 7 bridging bridging NN cord-015365-iqdi99pd 1093 8 to to IN cord-015365-iqdi99pd 1093 9 heart heart NN cord-015365-iqdi99pd 1093 10 transplantation transplantation NN cord-015365-iqdi99pd 1093 11 is be VBZ cord-015365-iqdi99pd 1093 12 possible possible JJ cord-015365-iqdi99pd 1093 13 even even RB cord-015365-iqdi99pd 1093 14 in in IN cord-015365-iqdi99pd 1093 15 cases case NNS cord-015365-iqdi99pd 1093 16 of of IN cord-015365-iqdi99pd 1093 17 severe severe JJ cord-015365-iqdi99pd 1093 18 bleeding bleeding JJ cord-015365-iqdi99pd 1093 19 complications complication NNS cord-015365-iqdi99pd 1093 20 . . . cord-015365-iqdi99pd 1094 1 Special special JJ cord-015365-iqdi99pd 1094 2 attention attention NN cord-015365-iqdi99pd 1094 3 is be VBZ cord-015365-iqdi99pd 1094 4 given give VBN cord-015365-iqdi99pd 1094 5 to to IN cord-015365-iqdi99pd 1094 6 the the DT cord-015365-iqdi99pd 1094 7 thin thin JJ cord-015365-iqdi99pd 1094 8 line line NN cord-015365-iqdi99pd 1094 9 between between IN cord-015365-iqdi99pd 1094 10 bleeding bleed VBG cord-015365-iqdi99pd 1094 11 complication complication NN cord-015365-iqdi99pd 1094 12 and and CC cord-015365-iqdi99pd 1094 13 necessary necessary JJ cord-015365-iqdi99pd 1094 14 anticoagulation anticoagulation NN cord-015365-iqdi99pd 1094 15 because because IN cord-015365-iqdi99pd 1094 16 of of IN cord-015365-iqdi99pd 1094 17 mechanical mechanical JJ cord-015365-iqdi99pd 1094 18 circulatory circulatory NN cord-015365-iqdi99pd 1094 19 assist assist NN cord-015365-iqdi99pd 1094 20 . . . cord-015365-iqdi99pd 1095 1 Background background NN cord-015365-iqdi99pd 1095 2 . . . cord-015365-iqdi99pd 1096 1 Advagraf Advagraf NNP cord-015365-iqdi99pd 1096 2 ( ( -LRB- cord-015365-iqdi99pd 1096 3 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1096 4 extended extend VBN cord-015365-iqdi99pd 1096 5 - - HYPH cord-015365-iqdi99pd 1096 6 release release NN cord-015365-iqdi99pd 1096 7 capsules capsule NNS cord-015365-iqdi99pd 1096 8 ) ) -RRB- cord-015365-iqdi99pd 1096 9 has have VBZ cord-015365-iqdi99pd 1096 10 been be VBN cord-015365-iqdi99pd 1096 11 tested test VBN cord-015365-iqdi99pd 1096 12 in in IN cord-015365-iqdi99pd 1096 13 de de JJ cord-015365-iqdi99pd 1096 14 - - JJ cord-015365-iqdi99pd 1096 15 novo novo JJ cord-015365-iqdi99pd 1096 16 liver liver NN cord-015365-iqdi99pd 1096 17 and and CC cord-015365-iqdi99pd 1096 18 renal renal JJ cord-015365-iqdi99pd 1096 19 transplant transplant NN cord-015365-iqdi99pd 1096 20 recipients recipient NNS cord-015365-iqdi99pd 1096 21 . . . cord-015365-iqdi99pd 1097 1 In in IN cord-015365-iqdi99pd 1097 2 cardiac cardiac JJ cord-015365-iqdi99pd 1097 3 transplantation transplantation NN cord-015365-iqdi99pd 1097 4 there there EX cord-015365-iqdi99pd 1097 5 exists exist VBZ cord-015365-iqdi99pd 1097 6 only only RB cord-015365-iqdi99pd 1097 7 data datum NNS cord-015365-iqdi99pd 1097 8 on on IN cord-015365-iqdi99pd 1097 9 conversion conversion NN cord-015365-iqdi99pd 1097 10 of of IN cord-015365-iqdi99pd 1097 11 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1097 12 to to IN cord-015365-iqdi99pd 1097 13 advagraf advagraf NNP cord-015365-iqdi99pd 1097 14 . . . cord-015365-iqdi99pd 1098 1 The the DT cord-015365-iqdi99pd 1098 2 aim aim NN cord-015365-iqdi99pd 1098 3 of of IN cord-015365-iqdi99pd 1098 4 this this DT cord-015365-iqdi99pd 1098 5 analysis analysis NN cord-015365-iqdi99pd 1098 6 was be VBD cord-015365-iqdi99pd 1098 7 to to TO cord-015365-iqdi99pd 1098 8 evaluate evaluate VB cord-015365-iqdi99pd 1098 9 efficacy efficacy NN cord-015365-iqdi99pd 1098 10 and and CC cord-015365-iqdi99pd 1098 11 safety safety NN cord-015365-iqdi99pd 1098 12 of of IN cord-015365-iqdi99pd 1098 13 de de FW cord-015365-iqdi99pd 1098 14 novo novo NNP cord-015365-iqdi99pd 1098 15 use use NN cord-015365-iqdi99pd 1098 16 of of IN cord-015365-iqdi99pd 1098 17 advagraf advagraf NN cord-015365-iqdi99pd 1098 18 in in IN cord-015365-iqdi99pd 1098 19 cardiac cardiac JJ cord-015365-iqdi99pd 1098 20 transplant transplant NN cord-015365-iqdi99pd 1098 21 patients patient NNS cord-015365-iqdi99pd 1098 22 . . . cord-015365-iqdi99pd 1099 1 Methods method NNS cord-015365-iqdi99pd 1099 2 . . . cord-015365-iqdi99pd 1100 1 10 10 CD cord-015365-iqdi99pd 1100 2 patients patient NNS cord-015365-iqdi99pd 1100 3 received receive VBD cord-015365-iqdi99pd 1100 4 advagraf advagraf NN cord-015365-iqdi99pd 1100 5 after after IN cord-015365-iqdi99pd 1100 6 ATG ATG NNP cord-015365-iqdi99pd 1100 7 induction induction NN cord-015365-iqdi99pd 1100 8 therapy therapy NN cord-015365-iqdi99pd 1100 9 , , , cord-015365-iqdi99pd 1100 10 8.1 8.1 CD cord-015365-iqdi99pd 1100 11 AE AE NNP cord-015365-iqdi99pd 1100 12 3.3 3.3 CD cord-015365-iqdi99pd 1100 13 days day NNS cord-015365-iqdi99pd 1100 14 after after IN cord-015365-iqdi99pd 1100 15 cardiac cardiac JJ cord-015365-iqdi99pd 1100 16 transplantation transplantation NN cord-015365-iqdi99pd 1100 17 . . . cord-015365-iqdi99pd 1101 1 Mean mean JJ cord-015365-iqdi99pd 1101 2 patient patient JJ cord-015365-iqdi99pd 1101 3 age age NN cord-015365-iqdi99pd 1101 4 was be VBD cord-015365-iqdi99pd 1101 5 40.1 40.1 CD cord-015365-iqdi99pd 1101 6 AE AE NNP cord-015365-iqdi99pd 1101 7 16.4 16.4 CD cord-015365-iqdi99pd 1101 8 years year NNS cord-015365-iqdi99pd 1101 9 . . . cord-015365-iqdi99pd 1102 1 All all DT cord-015365-iqdi99pd 1102 2 patients patient NNS cord-015365-iqdi99pd 1102 3 received receive VBD cord-015365-iqdi99pd 1102 4 also also RB cord-015365-iqdi99pd 1102 5 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 1102 6 and and CC cord-015365-iqdi99pd 1102 7 steroids steroid NNS cord-015365-iqdi99pd 1102 8 . . . cord-015365-iqdi99pd 1103 1 Follow follow VB cord-015365-iqdi99pd 1103 2 - - HYPH cord-015365-iqdi99pd 1103 3 up up NN cord-015365-iqdi99pd 1103 4 was be VBD cord-015365-iqdi99pd 1103 5 4.4 4.4 CD cord-015365-iqdi99pd 1103 6 AE AE NNP cord-015365-iqdi99pd 1103 7 1.7 1.7 CD cord-015365-iqdi99pd 1103 8 months month NNS cord-015365-iqdi99pd 1103 9 . . . cord-015365-iqdi99pd 1104 1 Dosages dosage NNS cord-015365-iqdi99pd 1104 2 , , , cord-015365-iqdi99pd 1104 3 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1104 4 drug drug NN cord-015365-iqdi99pd 1104 5 levels level NNS cord-015365-iqdi99pd 1104 6 ( ( -LRB- cord-015365-iqdi99pd 1104 7 tac tac NNP cord-015365-iqdi99pd 1104 8 ) ) -RRB- cord-015365-iqdi99pd 1104 9 and and CC cord-015365-iqdi99pd 1104 10 creatinine creatinine NNP cord-015365-iqdi99pd 1104 11 ( ( -LRB- cord-015365-iqdi99pd 1104 12 crea crea NNP cord-015365-iqdi99pd 1104 13 ) ) -RRB- cord-015365-iqdi99pd 1104 14 levels level NNS cord-015365-iqdi99pd 1104 15 were be VBD cord-015365-iqdi99pd 1104 16 recorded record VBN cord-015365-iqdi99pd 1104 17 1 1 CD cord-015365-iqdi99pd 1104 18 , , , cord-015365-iqdi99pd 1104 19 2 2 CD cord-015365-iqdi99pd 1104 20 weeks week NNS cord-015365-iqdi99pd 1104 21 and and CC cord-015365-iqdi99pd 1104 22 1 1 CD cord-015365-iqdi99pd 1104 23 to to TO cord-015365-iqdi99pd 1104 24 six six CD cord-015365-iqdi99pd 1104 25 months month NNS cord-015365-iqdi99pd 1104 26 post post NN cord-015365-iqdi99pd 1104 27 transplant transplant NN cord-015365-iqdi99pd 1104 28 . . . cord-015365-iqdi99pd 1105 1 Clinical clinical JJ cord-015365-iqdi99pd 1105 2 events event NNS cord-015365-iqdi99pd 1105 3 were be VBD cord-015365-iqdi99pd 1105 4 defined define VBN cord-015365-iqdi99pd 1105 5 as as IN cord-015365-iqdi99pd 1105 6 acute acute JJ cord-015365-iqdi99pd 1105 7 rejection rejection NN cord-015365-iqdi99pd 1105 8 , , , cord-015365-iqdi99pd 1105 9 infection infection NN cord-015365-iqdi99pd 1105 10 type type NN cord-015365-iqdi99pd 1105 11 , , , cord-015365-iqdi99pd 1105 12 new new JJ cord-015365-iqdi99pd 1105 13 onset onset NN cord-015365-iqdi99pd 1105 14 diabetes diabetes NN cord-015365-iqdi99pd 1105 15 mellitus mellitus NN cord-015365-iqdi99pd 1105 16 ( ( -LRB- cord-015365-iqdi99pd 1105 17 NODM NODM NNP cord-015365-iqdi99pd 1105 18 ) ) -RRB- cord-015365-iqdi99pd 1105 19 and and CC cord-015365-iqdi99pd 1105 20 renal renal JJ cord-015365-iqdi99pd 1105 21 dysfunction dysfunction NN cord-015365-iqdi99pd 1105 22 . . . cord-015365-iqdi99pd 1106 1 Results result NNS cord-015365-iqdi99pd 1106 2 . . . cord-015365-iqdi99pd 1107 1 Six six CD cord-015365-iqdi99pd 1107 2 - - HYPH cord-015365-iqdi99pd 1107 3 month month NN cord-015365-iqdi99pd 1107 4 survival survival NN cord-015365-iqdi99pd 1107 5 was be VBD cord-015365-iqdi99pd 1107 6 100 100 CD cord-015365-iqdi99pd 1107 7 % % NN cord-015365-iqdi99pd 1107 8 . . . cord-015365-iqdi99pd 1108 1 Two two CD cord-015365-iqdi99pd 1108 2 patients patient NNS cord-015365-iqdi99pd 1108 3 were be VBD cord-015365-iqdi99pd 1108 4 converted convert VBN cord-015365-iqdi99pd 1108 5 to to IN cord-015365-iqdi99pd 1108 6 cyclosporine cyclosporine NN cord-015365-iqdi99pd 1108 7 due due IN cord-015365-iqdi99pd 1108 8 to to IN cord-015365-iqdi99pd 1108 9 NODM NODM NNP cord-015365-iqdi99pd 1108 10 1 1 CD cord-015365-iqdi99pd 1108 11 and and CC cord-015365-iqdi99pd 1108 12 3 3 CD cord-015365-iqdi99pd 1108 13 months month NNS cord-015365-iqdi99pd 1108 14 post post NN cord-015365-iqdi99pd 1108 15 transplant transplant NN cord-015365-iqdi99pd 1108 16 . . . cord-015365-iqdi99pd 1109 1 No no DT cord-015365-iqdi99pd 1109 2 rejection rejection NN cord-015365-iqdi99pd 1109 3 episodes episode NNS cord-015365-iqdi99pd 1109 4 were be VBD cord-015365-iqdi99pd 1109 5 recorded record VBN cord-015365-iqdi99pd 1109 6 during during IN cord-015365-iqdi99pd 1109 7 follow follow NN cord-015365-iqdi99pd 1109 8 - - HYPH cord-015365-iqdi99pd 1109 9 up up NN cord-015365-iqdi99pd 1109 10 . . . cord-015365-iqdi99pd 1110 1 Two two CD cord-015365-iqdi99pd 1110 2 infections infection NNS cord-015365-iqdi99pd 1110 3 were be VBD cord-015365-iqdi99pd 1110 4 documented document VBN cord-015365-iqdi99pd 1110 5 6 6 CD cord-015365-iqdi99pd 1110 6 months month NNS cord-015365-iqdi99pd 1110 7 after after IN cord-015365-iqdi99pd 1110 8 transplant transplant NN cord-015365-iqdi99pd 1110 9 ( ( -LRB- cord-015365-iqdi99pd 1110 10 bacterial bacterial JJ cord-015365-iqdi99pd 1110 11 pneumonia pneumonia NN cord-015365-iqdi99pd 1110 12 and and CC cord-015365-iqdi99pd 1110 13 CMV CMV NNP cord-015365-iqdi99pd 1110 14 infection infection NN cord-015365-iqdi99pd 1110 15 ) ) -RRB- cord-015365-iqdi99pd 1110 16 . . . cord-015365-iqdi99pd 1111 1 Advagraf Advagraf NNP cord-015365-iqdi99pd 1111 2 starting starting NN cord-015365-iqdi99pd 1111 3 dose dose NN cord-015365-iqdi99pd 1111 4 was be VBD cord-015365-iqdi99pd 1111 5 6.2 6.2 CD cord-015365-iqdi99pd 1111 6 AE AE NNP cord-015365-iqdi99pd 1111 7 1.9 1.9 CD cord-015365-iqdi99pd 1111 8 mg mg NNP cord-015365-iqdi99pd 1111 9 / / SYM cord-015365-iqdi99pd 1111 10 d d NN cord-015365-iqdi99pd 1111 11 . . . cord-015365-iqdi99pd 1112 1 Crea Crea NNP cord-015365-iqdi99pd 1112 2 before before IN cord-015365-iqdi99pd 1112 3 start start NN cord-015365-iqdi99pd 1112 4 was be VBD cord-015365-iqdi99pd 1112 5 1.14 1.14 CD cord-015365-iqdi99pd 1112 6 AE AE NNP cord-015365-iqdi99pd 1112 7 0.34 0.34 CD cord-015365-iqdi99pd 1112 8 mg mg NNP cord-015365-iqdi99pd 1112 9 / / SYM cord-015365-iqdi99pd 1112 10 dl dl NNP cord-015365-iqdi99pd 1112 11 . . . cord-015365-iqdi99pd 1113 1 First first RB cord-015365-iqdi99pd 1113 2 measured measure VBN cord-015365-iqdi99pd 1113 3 tac tac NNP cord-015365-iqdi99pd 1113 4 levels level NNS cord-015365-iqdi99pd 1113 5 at at IN cord-015365-iqdi99pd 1113 6 steady steady JJ cord-015365-iqdi99pd 1113 7 state state NN cord-015365-iqdi99pd 1113 8 ( ( -LRB- cord-015365-iqdi99pd 1113 9 5 5 CD cord-015365-iqdi99pd 1113 10 days day NNS cord-015365-iqdi99pd 1113 11 post post VBP cord-015365-iqdi99pd 1113 12 drug drug NN cord-015365-iqdi99pd 1113 13 start start NN cord-015365-iqdi99pd 1113 14 ) ) -RRB- cord-015365-iqdi99pd 1113 15 were be VBD cord-015365-iqdi99pd 1113 16 7.8 7.8 CD cord-015365-iqdi99pd 1113 17 AE AE NNP cord-015365-iqdi99pd 1113 18 3.7 3.7 CD cord-015365-iqdi99pd 1113 19 ng ng NN cord-015365-iqdi99pd 1113 20 / / SYM cord-015365-iqdi99pd 1113 21 ml ml NN cord-015365-iqdi99pd 1113 22 . . . cord-015365-iqdi99pd 1114 1 Until until IN cord-015365-iqdi99pd 1114 2 the the DT cord-015365-iqdi99pd 1114 3 end end NN cord-015365-iqdi99pd 1114 4 of of IN cord-015365-iqdi99pd 1114 5 the the DT cord-015365-iqdi99pd 1114 6 first first JJ cord-015365-iqdi99pd 1114 7 month month NN cord-015365-iqdi99pd 1114 8 advagraf advagraf NNP cord-015365-iqdi99pd 1114 9 was be VBD cord-015365-iqdi99pd 1114 10 slowly slowly RB cord-015365-iqdi99pd 1114 11 increased increase VBN cord-015365-iqdi99pd 1114 12 to to IN cord-015365-iqdi99pd 1114 13 10.1 10.1 CD cord-015365-iqdi99pd 1114 14 AE AE NNP cord-015365-iqdi99pd 1114 15 1.9 1.9 CD cord-015365-iqdi99pd 1114 16 mg mg NNP cord-015365-iqdi99pd 1114 17 / / SYM cord-015365-iqdi99pd 1114 18 d d XX cord-015365-iqdi99pd 1114 19 with with IN cord-015365-iqdi99pd 1114 20 tac tac NNP cord-015365-iqdi99pd 1114 21 levels level NNS cord-015365-iqdi99pd 1114 22 of of IN cord-015365-iqdi99pd 1114 23 10.7 10.7 CD cord-015365-iqdi99pd 1114 24 AE AE NNP cord-015365-iqdi99pd 1114 25 2.8 2.8 CD cord-015365-iqdi99pd 1114 26 ng ng NN cord-015365-iqdi99pd 1114 27 / / SYM cord-015365-iqdi99pd 1114 28 ml ml NN cord-015365-iqdi99pd 1114 29 and and CC cord-015365-iqdi99pd 1114 30 crea crea NNP cord-015365-iqdi99pd 1114 31 of of IN cord-015365-iqdi99pd 1114 32 1.22 1.22 CD cord-015365-iqdi99pd 1114 33 AE AE NNP cord-015365-iqdi99pd 1114 34 0.31 0.31 CD cord-015365-iqdi99pd 1114 35 mg mg NNP cord-015365-iqdi99pd 1114 36 / / SYM cord-015365-iqdi99pd 1114 37 dl dl NNP cord-015365-iqdi99pd 1114 38 . . . cord-015365-iqdi99pd 1115 1 Three three CD cord-015365-iqdi99pd 1115 2 and and CC cord-015365-iqdi99pd 1115 3 six six CD cord-015365-iqdi99pd 1115 4 month month NN cord-015365-iqdi99pd 1115 5 drug drug NN cord-015365-iqdi99pd 1115 6 doses dose NNS cord-015365-iqdi99pd 1115 7 were be VBD cord-015365-iqdi99pd 1115 8 9.3 9.3 CD cord-015365-iqdi99pd 1115 9 AE AE NNP cord-015365-iqdi99pd 1115 10 2.11 2.11 CD cord-015365-iqdi99pd 1115 11 and and CC cord-015365-iqdi99pd 1115 12 8.2 8.2 CD cord-015365-iqdi99pd 1115 13 AE AE NNP cord-015365-iqdi99pd 1115 14 0.8 0.8 CD cord-015365-iqdi99pd 1115 15 mg mg NN cord-015365-iqdi99pd 1115 16 with with IN cord-015365-iqdi99pd 1115 17 corresponding correspond VBG cord-015365-iqdi99pd 1115 18 tac tac NNP cord-015365-iqdi99pd 1115 19 levels level NNS cord-015365-iqdi99pd 1115 20 of of IN cord-015365-iqdi99pd 1115 21 11.2 11.2 CD cord-015365-iqdi99pd 1115 22 AE AE NNP cord-015365-iqdi99pd 1115 23 2.9 2.9 CD cord-015365-iqdi99pd 1115 24 and and CC cord-015365-iqdi99pd 1115 25 11.2 11.2 CD cord-015365-iqdi99pd 1115 26 AE AE NNP cord-015365-iqdi99pd 1115 27 1.3 1.3 CD cord-015365-iqdi99pd 1115 28 ng ng NN cord-015365-iqdi99pd 1115 29 / / SYM cord-015365-iqdi99pd 1115 30 ml ml NN cord-015365-iqdi99pd 1115 31 . . . cord-015365-iqdi99pd 1116 1 Crea Crea NNP cord-015365-iqdi99pd 1116 2 was be VBD cord-015365-iqdi99pd 1116 3 1.47 1.47 CD cord-015365-iqdi99pd 1116 4 AE AE NNP cord-015365-iqdi99pd 1116 5 0.22 0.22 CD cord-015365-iqdi99pd 1116 6 and and CC cord-015365-iqdi99pd 1116 7 1.49 1.49 CD cord-015365-iqdi99pd 1116 8 AE AE NNP cord-015365-iqdi99pd 1116 9 0.32 0.32 CD cord-015365-iqdi99pd 1116 10 mg mg NNP cord-015365-iqdi99pd 1116 11 / / SYM cord-015365-iqdi99pd 1116 12 dl dl NNP cord-015365-iqdi99pd 1116 13 . . . cord-015365-iqdi99pd 1117 1 There there EX cord-015365-iqdi99pd 1117 2 were be VBD cord-015365-iqdi99pd 1117 3 no no DT cord-015365-iqdi99pd 1117 4 events event NNS cord-015365-iqdi99pd 1117 5 of of IN cord-015365-iqdi99pd 1117 6 renal renal JJ cord-015365-iqdi99pd 1117 7 failure failure NN cord-015365-iqdi99pd 1117 8 . . . cord-015365-iqdi99pd 1118 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1118 2 . . . cord-015365-iqdi99pd 1119 1 Advagraf Advagraf NNP cord-015365-iqdi99pd 1119 2 de de NNP cord-015365-iqdi99pd 1119 3 - - JJ cord-015365-iqdi99pd 1119 4 novo novo JJ cord-015365-iqdi99pd 1119 5 therapy therapy NN cord-015365-iqdi99pd 1119 6 shows show VBZ cord-015365-iqdi99pd 1119 7 acceptable acceptable JJ cord-015365-iqdi99pd 1119 8 efficacy efficacy NN cord-015365-iqdi99pd 1119 9 and and CC cord-015365-iqdi99pd 1119 10 safety safety NN cord-015365-iqdi99pd 1119 11 early early RB cord-015365-iqdi99pd 1119 12 after after IN cord-015365-iqdi99pd 1119 13 cardiac cardiac JJ cord-015365-iqdi99pd 1119 14 transplantation transplantation NN cord-015365-iqdi99pd 1119 15 . . . cord-015365-iqdi99pd 1120 1 ATGinduction atginduction NN cord-015365-iqdi99pd 1120 2 therapy therapy NN cord-015365-iqdi99pd 1120 3 might may MD cord-015365-iqdi99pd 1120 4 be be VB cord-015365-iqdi99pd 1120 5 responsible responsible JJ cord-015365-iqdi99pd 1120 6 for for IN cord-015365-iqdi99pd 1120 7 a a DT cord-015365-iqdi99pd 1120 8 low low JJ cord-015365-iqdi99pd 1120 9 risk risk NN cord-015365-iqdi99pd 1120 10 of of IN cord-015365-iqdi99pd 1120 11 acute acute JJ cord-015365-iqdi99pd 1120 12 rejection rejection NN cord-015365-iqdi99pd 1120 13 despite despite IN cord-015365-iqdi99pd 1120 14 lower low JJR cord-015365-iqdi99pd 1120 15 early early JJ cord-015365-iqdi99pd 1120 16 tac tac NNP cord-015365-iqdi99pd 1120 17 levels level NNS cord-015365-iqdi99pd 1120 18 . . . cord-015365-iqdi99pd 1121 1 Usage usage NN cord-015365-iqdi99pd 1121 2 of of IN cord-015365-iqdi99pd 1121 3 If if NN cord-015365-iqdi99pd 1121 4 - - HYPH cord-015365-iqdi99pd 1121 5 inhibitors inhibitor NNS cord-015365-iqdi99pd 1121 6 in in IN cord-015365-iqdi99pd 1121 7 regulation regulation NN cord-015365-iqdi99pd 1121 8 of of IN cord-015365-iqdi99pd 1121 9 heart heart NN cord-015365-iqdi99pd 1121 10 rate rate NN cord-015365-iqdi99pd 1121 11 after after IN cord-015365-iqdi99pd 1121 12 heart heart NN cord-015365-iqdi99pd 1121 13 transplantation transplantation NN cord-015365-iqdi99pd 1121 14 Background Background NNP cord-015365-iqdi99pd 1121 15 . . . cord-015365-iqdi99pd 1122 1 Due due IN cord-015365-iqdi99pd 1122 2 to to IN cord-015365-iqdi99pd 1122 3 denervation denervation NN cord-015365-iqdi99pd 1122 4 of of IN cord-015365-iqdi99pd 1122 5 the the DT cord-015365-iqdi99pd 1122 6 heart heart NN cord-015365-iqdi99pd 1122 7 from from IN cord-015365-iqdi99pd 1122 8 N. N. NNP cord-015365-iqdi99pd 1122 9 vagus vagus NN cord-015365-iqdi99pd 1122 10 , , , cord-015365-iqdi99pd 1122 11 patients patient NNS cord-015365-iqdi99pd 1122 12 physiologically physiologically RB cord-015365-iqdi99pd 1122 13 have have VBP cord-015365-iqdi99pd 1122 14 a a DT cord-015365-iqdi99pd 1122 15 heart heart NN cord-015365-iqdi99pd 1122 16 rate rate NN cord-015365-iqdi99pd 1122 17 of of IN cord-015365-iqdi99pd 1122 18 90 90 CD cord-015365-iqdi99pd 1122 19 - - SYM cord-015365-iqdi99pd 1122 20 100 100 CD cord-015365-iqdi99pd 1122 21 beats beat NNS cord-015365-iqdi99pd 1122 22 per per IN cord-015365-iqdi99pd 1122 23 minute minute NN cord-015365-iqdi99pd 1122 24 ( ( -LRB- cord-015365-iqdi99pd 1122 25 bpm bpm NNP cord-015365-iqdi99pd 1122 26 ) ) -RRB- cord-015365-iqdi99pd 1122 27 after after IN cord-015365-iqdi99pd 1122 28 heart heart NN cord-015365-iqdi99pd 1122 29 transplantation transplantation NN cord-015365-iqdi99pd 1122 30 . . . cord-015365-iqdi99pd 1123 1 Inhibiting inhibit VBG cord-015365-iqdi99pd 1123 2 the the DT cord-015365-iqdi99pd 1123 3 funnychannels funnychannel NNS cord-015365-iqdi99pd 1123 4 ( ( -LRB- cord-015365-iqdi99pd 1123 5 If if IN cord-015365-iqdi99pd 1123 6 ) ) -RRB- cord-015365-iqdi99pd 1123 7 of of IN cord-015365-iqdi99pd 1123 8 the the DT cord-015365-iqdi99pd 1123 9 pacing pacing NN cord-015365-iqdi99pd 1123 10 - - HYPH cord-015365-iqdi99pd 1123 11 cells cell NNS cord-015365-iqdi99pd 1123 12 of of IN cord-015365-iqdi99pd 1123 13 the the DT cord-015365-iqdi99pd 1123 14 sinus sinus NN cord-015365-iqdi99pd 1123 15 node node NN cord-015365-iqdi99pd 1123 16 reduces reduce VBZ cord-015365-iqdi99pd 1123 17 ionic ionic NN cord-015365-iqdi99pd 1123 18 - - HYPH cord-015365-iqdi99pd 1123 19 influx influx JJ cord-015365-iqdi99pd 1123 20 and and CC cord-015365-iqdi99pd 1123 21 spontaneous spontaneous JJ cord-015365-iqdi99pd 1123 22 depolarization depolarization NN cord-015365-iqdi99pd 1123 23 and and CC cord-015365-iqdi99pd 1123 24 hereby hereby RB cord-015365-iqdi99pd 1123 25 decreases decrease VBZ cord-015365-iqdi99pd 1123 26 the the DT cord-015365-iqdi99pd 1123 27 heart heart NN cord-015365-iqdi99pd 1123 28 rate rate NN cord-015365-iqdi99pd 1123 29 . . . cord-015365-iqdi99pd 1124 1 To to TO cord-015365-iqdi99pd 1124 2 improve improve VB cord-015365-iqdi99pd 1124 3 myocardial myocardial JJ cord-015365-iqdi99pd 1124 4 oxygenation oxygenation NN cord-015365-iqdi99pd 1124 5 by by IN cord-015365-iqdi99pd 1124 6 extending extend VBG cord-015365-iqdi99pd 1124 7 diastolic diastolic JJ cord-015365-iqdi99pd 1124 8 time time NN cord-015365-iqdi99pd 1124 9 , , , cord-015365-iqdi99pd 1124 10 reducing reduce VBG cord-015365-iqdi99pd 1124 11 the the DT cord-015365-iqdi99pd 1124 12 heart heart NN cord-015365-iqdi99pd 1124 13 rate rate NN cord-015365-iqdi99pd 1124 14 is be VBZ cord-015365-iqdi99pd 1124 15 an an DT cord-015365-iqdi99pd 1124 16 important important JJ cord-015365-iqdi99pd 1124 17 goal goal NN cord-015365-iqdi99pd 1124 18 for for IN cord-015365-iqdi99pd 1124 19 these these DT cord-015365-iqdi99pd 1124 20 patients patient NNS cord-015365-iqdi99pd 1124 21 . . . cord-015365-iqdi99pd 1125 1 Objective objective NN cord-015365-iqdi99pd 1125 2 of of IN cord-015365-iqdi99pd 1125 3 the the DT cord-015365-iqdi99pd 1125 4 current current JJ cord-015365-iqdi99pd 1125 5 study study NN cord-015365-iqdi99pd 1125 6 is be VBZ cord-015365-iqdi99pd 1125 7 to to TO cord-015365-iqdi99pd 1125 8 show show VB cord-015365-iqdi99pd 1125 9 the the DT cord-015365-iqdi99pd 1125 10 efficacy efficacy NN cord-015365-iqdi99pd 1125 11 of of IN cord-015365-iqdi99pd 1125 12 the the DT cord-015365-iqdi99pd 1125 13 If if IN cord-015365-iqdi99pd 1125 14 - - HYPH cord-015365-iqdi99pd 1125 15 inhibitor inhibitor NN cord-015365-iqdi99pd 1125 16 ivabradine ivabradine NN cord-015365-iqdi99pd 1125 17 ( ( -LRB- cord-015365-iqdi99pd 1125 18 Procoralan Procoralan NNP cord-015365-iqdi99pd 1125 19 + + CC cord-015365-iqdi99pd 1125 20 ) ) -RRB- cord-015365-iqdi99pd 1125 21 on on IN cord-015365-iqdi99pd 1125 22 the the DT cord-015365-iqdi99pd 1125 23 transplanted transplanted JJ cord-015365-iqdi99pd 1125 24 heart heart NN cord-015365-iqdi99pd 1125 25 . . . cord-015365-iqdi99pd 1126 1 Methods method NNS cord-015365-iqdi99pd 1126 2 . . . cord-015365-iqdi99pd 1127 1 This this DT cord-015365-iqdi99pd 1127 2 is be VBZ cord-015365-iqdi99pd 1127 3 a a DT cord-015365-iqdi99pd 1127 4 single single JJ cord-015365-iqdi99pd 1127 5 - - HYPH cord-015365-iqdi99pd 1127 6 center center NN cord-015365-iqdi99pd 1127 7 retrospective retrospective JJ cord-015365-iqdi99pd 1127 8 study study NN cord-015365-iqdi99pd 1127 9 including include VBG cord-015365-iqdi99pd 1127 10 143 143 CD cord-015365-iqdi99pd 1127 11 patients patient NNS cord-015365-iqdi99pd 1127 12 , , , cord-015365-iqdi99pd 1127 13 who who WP cord-015365-iqdi99pd 1127 14 underwent undergo VBD cord-015365-iqdi99pd 1127 15 heart heart NN cord-015365-iqdi99pd 1127 16 transplantation transplantation NN cord-015365-iqdi99pd 1127 17 from from IN cord-015365-iqdi99pd 1127 18 1985 1985 CD cord-015365-iqdi99pd 1127 19 to to IN cord-015365-iqdi99pd 1127 20 2011 2011 CD cord-015365-iqdi99pd 1127 21 at at IN cord-015365-iqdi99pd 1127 22 our -PRON- PRP$ cord-015365-iqdi99pd 1127 23 center center NN cord-015365-iqdi99pd 1127 24 in in IN cord-015365-iqdi99pd 1127 25 Vienna Vienna NNP cord-015365-iqdi99pd 1127 26 and and CC cord-015365-iqdi99pd 1127 27 who who WP cord-015365-iqdi99pd 1127 28 were be VBD cord-015365-iqdi99pd 1127 29 in in IN cord-015365-iqdi99pd 1127 30 need need NN cord-015365-iqdi99pd 1127 31 of of IN cord-015365-iqdi99pd 1127 32 a a DT cord-015365-iqdi99pd 1127 33 heart heart NN cord-015365-iqdi99pd 1127 34 rate rate NN cord-015365-iqdi99pd 1127 35 regulating regulate VBG cord-015365-iqdi99pd 1127 36 therapy therapy NN cord-015365-iqdi99pd 1127 37 after after IN cord-015365-iqdi99pd 1127 38 transplantation transplantation NN cord-015365-iqdi99pd 1127 39 . . . cord-015365-iqdi99pd 1128 1 Only only RB cord-015365-iqdi99pd 1128 2 patients patient NNS cord-015365-iqdi99pd 1128 3 in in IN cord-015365-iqdi99pd 1128 4 stable stable JJ cord-015365-iqdi99pd 1128 5 conditions condition NNS cord-015365-iqdi99pd 1128 6 and and CC cord-015365-iqdi99pd 1128 7 with with IN cord-015365-iqdi99pd 1128 8 sinus sinus NN cord-015365-iqdi99pd 1128 9 rhythm rhythm NN cord-015365-iqdi99pd 1128 10 were be VBD cord-015365-iqdi99pd 1128 11 treated treat VBN cord-015365-iqdi99pd 1128 12 with with IN cord-015365-iqdi99pd 1128 13 ivabradine ivabradine NN cord-015365-iqdi99pd 1128 14 . . . cord-015365-iqdi99pd 1129 1 An an DT cord-015365-iqdi99pd 1129 2 average average JJ cord-015365-iqdi99pd 1129 3 dose dose NN cord-015365-iqdi99pd 1129 4 of of IN cord-015365-iqdi99pd 1129 5 10 10 CD cord-015365-iqdi99pd 1129 6 mg mg NN cord-015365-iqdi99pd 1129 7 per per IN cord-015365-iqdi99pd 1129 8 day day NN cord-015365-iqdi99pd 1129 9 was be VBD cord-015365-iqdi99pd 1129 10 used use VBN cord-015365-iqdi99pd 1129 11 to to TO cord-015365-iqdi99pd 1129 12 control control VB cord-015365-iqdi99pd 1129 13 the the DT cord-015365-iqdi99pd 1129 14 heart heart NN cord-015365-iqdi99pd 1129 15 rate rate NN cord-015365-iqdi99pd 1129 16 . . . cord-015365-iqdi99pd 1130 1 Analyzed analyze VBN cord-015365-iqdi99pd 1130 2 data datum NNS cord-015365-iqdi99pd 1130 3 were be VBD cord-015365-iqdi99pd 1130 4 collected collect VBN cord-015365-iqdi99pd 1130 5 during during IN cord-015365-iqdi99pd 1130 6 routine routine JJ cord-015365-iqdi99pd 1130 7 checkups checkup NNS cord-015365-iqdi99pd 1130 8 in in IN cord-015365-iqdi99pd 1130 9 our -PRON- PRP$ cord-015365-iqdi99pd 1130 10 long long JJ cord-015365-iqdi99pd 1130 11 - - HYPH cord-015365-iqdi99pd 1130 12 term term NN cord-015365-iqdi99pd 1130 13 outpatient outpatient NN cord-015365-iqdi99pd 1130 14 - - HYPH cord-015365-iqdi99pd 1130 15 clinic clinic NN cord-015365-iqdi99pd 1130 16 and and CC cord-015365-iqdi99pd 1130 17 during during IN cord-015365-iqdi99pd 1130 18 ergometry ergometry NN cord-015365-iqdi99pd 1130 19 examination examination NN cord-015365-iqdi99pd 1130 20 by by IN cord-015365-iqdi99pd 1130 21 periodical periodical JJ cord-015365-iqdi99pd 1130 22 measurements measurement NNS cord-015365-iqdi99pd 1130 23 of of IN cord-015365-iqdi99pd 1130 24 heart heart NN cord-015365-iqdi99pd 1130 25 - - HYPH cord-015365-iqdi99pd 1130 26 rate rate NN cord-015365-iqdi99pd 1130 27 , , , cord-015365-iqdi99pd 1130 28 bloodpressure bloodpressure NN cord-015365-iqdi99pd 1130 29 and and CC cord-015365-iqdi99pd 1130 30 ECG ECG NNP cord-015365-iqdi99pd 1130 31 . . . cord-015365-iqdi99pd 1131 1 Results result NNS cord-015365-iqdi99pd 1131 2 . . . cord-015365-iqdi99pd 1132 1 Mean mean JJ cord-015365-iqdi99pd 1132 2 age age NN cord-015365-iqdi99pd 1132 3 at at IN cord-015365-iqdi99pd 1132 4 the the DT cord-015365-iqdi99pd 1132 5 time time NN cord-015365-iqdi99pd 1132 6 of of IN cord-015365-iqdi99pd 1132 7 transplantation transplantation NN cord-015365-iqdi99pd 1132 8 was be VBD cord-015365-iqdi99pd 1132 9 51.3 51.3 CD cord-015365-iqdi99pd 1132 10 AE AE NNP cord-015365-iqdi99pd 1132 11 11.9 11.9 CD cord-015365-iqdi99pd 1132 12 years year NNS cord-015365-iqdi99pd 1132 13 , , , cord-015365-iqdi99pd 1132 14 117 117 CD cord-015365-iqdi99pd 1132 15 patients patient NNS cord-015365-iqdi99pd 1132 16 ( ( -LRB- cord-015365-iqdi99pd 1132 17 81.8 81.8 CD cord-015365-iqdi99pd 1132 18 % % NN cord-015365-iqdi99pd 1132 19 ) ) -RRB- cord-015365-iqdi99pd 1132 20 were be VBD cord-015365-iqdi99pd 1132 21 male male JJ cord-015365-iqdi99pd 1132 22 ( ( -LRB- cord-015365-iqdi99pd 1132 23 age age NN cord-015365-iqdi99pd 1132 24 16 16 CD cord-015365-iqdi99pd 1132 25 - - SYM cord-015365-iqdi99pd 1132 26 71 71 CD cord-015365-iqdi99pd 1132 27 years year NNS cord-015365-iqdi99pd 1132 28 ) ) -RRB- cord-015365-iqdi99pd 1132 29 and and CC cord-015365-iqdi99pd 1132 30 26 26 CD cord-015365-iqdi99pd 1132 31 patients patient NNS cord-015365-iqdi99pd 1132 32 ( ( -LRB- cord-015365-iqdi99pd 1132 33 18.2 18.2 CD cord-015365-iqdi99pd 1132 34 % % NN cord-015365-iqdi99pd 1132 35 ) ) -RRB- cord-015365-iqdi99pd 1132 36 were be VBD cord-015365-iqdi99pd 1132 37 female female JJ cord-015365-iqdi99pd 1132 38 ( ( -LRB- cord-015365-iqdi99pd 1132 39 age age NN cord-015365-iqdi99pd 1132 40 14 14 CD cord-015365-iqdi99pd 1132 41 - - SYM cord-015365-iqdi99pd 1132 42 68 68 CD cord-015365-iqdi99pd 1132 43 years year NNS cord-015365-iqdi99pd 1132 44 ) ) -RRB- cord-015365-iqdi99pd 1132 45 . . . cord-015365-iqdi99pd 1133 1 Before before IN cord-015365-iqdi99pd 1133 2 establishing establish VBG cord-015365-iqdi99pd 1133 3 the the DT cord-015365-iqdi99pd 1133 4 Procoralan Procoralan NNP cord-015365-iqdi99pd 1133 5 + + CC cord-015365-iqdi99pd 1133 6 therapy therapy NN cord-015365-iqdi99pd 1133 7 , , , cord-015365-iqdi99pd 1133 8 patients patient NNS cord-015365-iqdi99pd 1133 9 had have VBD cord-015365-iqdi99pd 1133 10 an an DT cord-015365-iqdi99pd 1133 11 average average JJ cord-015365-iqdi99pd 1133 12 heart heart NN cord-015365-iqdi99pd 1133 13 rate rate NN cord-015365-iqdi99pd 1133 14 of of IN cord-015365-iqdi99pd 1133 15 96.2 96.2 CD cord-015365-iqdi99pd 1133 16 AE AE NNP cord-015365-iqdi99pd 1133 17 11.9 11.9 CD cord-015365-iqdi99pd 1133 18 bpm bpm NN cord-015365-iqdi99pd 1133 19 . . . cord-015365-iqdi99pd 1134 1 With with IN cord-015365-iqdi99pd 1134 2 the the DT cord-015365-iqdi99pd 1134 3 Procoralan Procoralan NNP cord-015365-iqdi99pd 1134 4 + + CC cord-015365-iqdi99pd 1134 5 therapy therapy NN cord-015365-iqdi99pd 1134 6 , , , cord-015365-iqdi99pd 1134 7 patients patient NNS cord-015365-iqdi99pd 1134 8 had have VBD cord-015365-iqdi99pd 1134 9 an an DT cord-015365-iqdi99pd 1134 10 average average JJ cord-015365-iqdi99pd 1134 11 heart heart NN cord-015365-iqdi99pd 1134 12 rate rate NN cord-015365-iqdi99pd 1134 13 of of IN cord-015365-iqdi99pd 1134 14 83.1 83.1 CD cord-015365-iqdi99pd 1134 15 AE AE NNP cord-015365-iqdi99pd 1134 16 9.5 9.5 CD cord-015365-iqdi99pd 1134 17 bpm bpm NN cord-015365-iqdi99pd 1134 18 . . . cord-015365-iqdi99pd 1135 1 After after IN cord-015365-iqdi99pd 1135 2 an an DT cord-015365-iqdi99pd 1135 3 average average JJ cord-015365-iqdi99pd 1135 4 time time NN cord-015365-iqdi99pd 1135 5 of of IN cord-015365-iqdi99pd 1135 6 1.8 1.8 CD cord-015365-iqdi99pd 1135 7 AE AE NNP cord-015365-iqdi99pd 1135 8 1.4 1.4 CD cord-015365-iqdi99pd 1135 9 years year NNS cord-015365-iqdi99pd 1135 10 , , , cord-015365-iqdi99pd 1135 11 usage usage NN cord-015365-iqdi99pd 1135 12 of of IN cord-015365-iqdi99pd 1135 13 ivabradine ivabradine NN cord-015365-iqdi99pd 1135 14 has have VBZ cord-015365-iqdi99pd 1135 15 reduced reduce VBN cord-015365-iqdi99pd 1135 16 the the DT cord-015365-iqdi99pd 1135 17 heart heart NN cord-015365-iqdi99pd 1135 18 rate rate NN cord-015365-iqdi99pd 1135 19 by by IN cord-015365-iqdi99pd 1135 20 14.9 14.9 CD cord-015365-iqdi99pd 1135 21 AE AE NNP cord-015365-iqdi99pd 1135 22 9.4 9.4 CD cord-015365-iqdi99pd 1135 23 % % NN cord-015365-iqdi99pd 1135 24 . . . cord-015365-iqdi99pd 1136 1 In in IN cord-015365-iqdi99pd 1136 2 7 7 CD cord-015365-iqdi99pd 1136 3 cases case NNS cord-015365-iqdi99pd 1136 4 ( ( -LRB- cord-015365-iqdi99pd 1136 5 4.8 4.8 CD cord-015365-iqdi99pd 1136 6 % % NN cord-015365-iqdi99pd 1136 7 ) ) -RRB- cord-015365-iqdi99pd 1136 8 we -PRON- PRP cord-015365-iqdi99pd 1136 9 had have VBD cord-015365-iqdi99pd 1136 10 to to TO cord-015365-iqdi99pd 1136 11 terminate terminate VB cord-015365-iqdi99pd 1136 12 therapy therapy NN cord-015365-iqdi99pd 1136 13 because because IN cord-015365-iqdi99pd 1136 14 of of IN cord-015365-iqdi99pd 1136 15 gastro gastro JJ cord-015365-iqdi99pd 1136 16 - - JJ cord-015365-iqdi99pd 1136 17 intestinal intestinal JJ cord-015365-iqdi99pd 1136 18 side side NN cord-015365-iqdi99pd 1136 19 effects effect NNS cord-015365-iqdi99pd 1136 20 and and CC cord-015365-iqdi99pd 1136 21 in in IN cord-015365-iqdi99pd 1136 22 4 4 CD cord-015365-iqdi99pd 1136 23 cases case NNS cord-015365-iqdi99pd 1136 24 ( ( -LRB- cord-015365-iqdi99pd 1136 25 2.7 2.7 CD cord-015365-iqdi99pd 1136 26 % % NN cord-015365-iqdi99pd 1136 27 ) ) -RRB- cord-015365-iqdi99pd 1136 28 even even RB cord-015365-iqdi99pd 1136 29 under under IN cord-015365-iqdi99pd 1136 30 lowest low JJS cord-015365-iqdi99pd 1136 31 ivabradine ivabradine NN cord-015365-iqdi99pd 1136 32 dosage dosage NN cord-015365-iqdi99pd 1136 33 patient patient NN cord-015365-iqdi99pd 1136 34 developed develop VBD cord-015365-iqdi99pd 1136 35 bradycardia bradycardia NN cord-015365-iqdi99pd 1136 36 . . . cord-015365-iqdi99pd 1137 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1137 2 . . . cord-015365-iqdi99pd 1138 1 Using use VBG cord-015365-iqdi99pd 1138 2 ivabradine ivabradine NN cord-015365-iqdi99pd 1138 3 after after IN cord-015365-iqdi99pd 1138 4 heart heart NN cord-015365-iqdi99pd 1138 5 transplantation transplantation NN cord-015365-iqdi99pd 1138 6 is be VBZ cord-015365-iqdi99pd 1138 7 a a DT cord-015365-iqdi99pd 1138 8 safe safe JJ cord-015365-iqdi99pd 1138 9 way way NN cord-015365-iqdi99pd 1138 10 to to TO cord-015365-iqdi99pd 1138 11 lower lower VB cord-015365-iqdi99pd 1138 12 heart heart NN cord-015365-iqdi99pd 1138 13 rate rate NN cord-015365-iqdi99pd 1138 14 and and CC cord-015365-iqdi99pd 1138 15 could could MD cord-015365-iqdi99pd 1138 16 become become VB cord-015365-iqdi99pd 1138 17 a a DT cord-015365-iqdi99pd 1138 18 new new JJ cord-015365-iqdi99pd 1138 19 indication indication NN cord-015365-iqdi99pd 1138 20 for for IN cord-015365-iqdi99pd 1138 21 If if NN cord-015365-iqdi99pd 1138 22 - - HYPH cord-015365-iqdi99pd 1138 23 inhibitors inhibitor NNS cord-015365-iqdi99pd 1138 24 . . . cord-015365-iqdi99pd 1139 1 The the DT cord-015365-iqdi99pd 1139 2 individual individual JJ cord-015365-iqdi99pd 1139 3 dosage dosage NN cord-015365-iqdi99pd 1139 4 for for IN cord-015365-iqdi99pd 1139 5 each each DT cord-015365-iqdi99pd 1139 6 patient patient NN cord-015365-iqdi99pd 1139 7 has have VBZ cord-015365-iqdi99pd 1139 8 to to TO cord-015365-iqdi99pd 1139 9 be be VB cord-015365-iqdi99pd 1139 10 found find VBN cord-015365-iqdi99pd 1139 11 in in IN cord-015365-iqdi99pd 1139 12 augmenting augment VBG cord-015365-iqdi99pd 1139 13 the the DT cord-015365-iqdi99pd 1139 14 initial initial JJ cord-015365-iqdi99pd 1139 15 daily daily JJ cord-015365-iqdi99pd 1139 16 dosage dosage NN cord-015365-iqdi99pd 1139 17 of of IN cord-015365-iqdi99pd 1139 18 5 5 CD cord-015365-iqdi99pd 1139 19 mg mg NNS cord-015365-iqdi99pd 1139 20 slowly slowly RB cord-015365-iqdi99pd 1139 21 to to IN cord-015365-iqdi99pd 1139 22 the the DT cord-015365-iqdi99pd 1139 23 optimum optimum JJ cord-015365-iqdi99pd 1139 24 dosage dosage NN cord-015365-iqdi99pd 1139 25 of of IN cord-015365-iqdi99pd 1139 26 10 10 CD cord-015365-iqdi99pd 1139 27 mg mg NN cord-015365-iqdi99pd 1139 28 per per IN cord-015365-iqdi99pd 1139 29 day day NN cord-015365-iqdi99pd 1139 30 . . . cord-015365-iqdi99pd 1140 1 Comparison comparison NN cord-015365-iqdi99pd 1140 2 between between IN cord-015365-iqdi99pd 1140 3 referral referral NN cord-015365-iqdi99pd 1140 4 and and CC cord-015365-iqdi99pd 1140 5 explant explant JJ cord-015365-iqdi99pd 1140 6 diagnoses diagnosis NNS cord-015365-iqdi99pd 1140 7 in in IN cord-015365-iqdi99pd 1140 8 lung lung NN cord-015365-iqdi99pd 1140 9 transplant transplant NN cord-015365-iqdi99pd 1140 10 recipients recipient NNS cord-015365-iqdi99pd 1140 11 : : : cord-015365-iqdi99pd 1140 12 discrepancies discrepancy NNS cord-015365-iqdi99pd 1140 13 and and CC cord-015365-iqdi99pd 1140 14 additional additional JJ cord-015365-iqdi99pd 1140 15 findings finding NNS cord-015365-iqdi99pd 1140 16 Background Background NNP cord-015365-iqdi99pd 1140 17 . . . cord-015365-iqdi99pd 1141 1 Lung lung NN cord-015365-iqdi99pd 1141 2 transplantation transplantation NN cord-015365-iqdi99pd 1141 3 is be VBZ cord-015365-iqdi99pd 1141 4 a a DT cord-015365-iqdi99pd 1141 5 widely widely RB cord-015365-iqdi99pd 1141 6 accepted accept VBN cord-015365-iqdi99pd 1141 7 therapeutic therapeutic JJ cord-015365-iqdi99pd 1141 8 option option NN cord-015365-iqdi99pd 1141 9 for for IN cord-015365-iqdi99pd 1141 10 a a DT cord-015365-iqdi99pd 1141 11 range range NN cord-015365-iqdi99pd 1141 12 of of IN cord-015365-iqdi99pd 1141 13 pulmonary pulmonary JJ cord-015365-iqdi99pd 1141 14 conditions condition NNS cord-015365-iqdi99pd 1141 15 in in IN cord-015365-iqdi99pd 1141 16 which which WDT cord-015365-iqdi99pd 1141 17 the the DT cord-015365-iqdi99pd 1141 18 diagnosis diagnosis NN cord-015365-iqdi99pd 1141 19 is be VBZ cord-015365-iqdi99pd 1141 20 often often RB cord-015365-iqdi99pd 1141 21 based base VBN cord-015365-iqdi99pd 1141 22 on on IN cord-015365-iqdi99pd 1141 23 clinical clinical JJ cord-015365-iqdi99pd 1141 24 data datum NNS cord-015365-iqdi99pd 1141 25 or or CC cord-015365-iqdi99pd 1141 26 on on IN cord-015365-iqdi99pd 1141 27 limited limited JJ cord-015365-iqdi99pd 1141 28 biopsy biopsy NN cord-015365-iqdi99pd 1141 29 material material NN cord-015365-iqdi99pd 1141 30 . . . cord-015365-iqdi99pd 1142 1 Posttransplantation posttransplantation NN cord-015365-iqdi99pd 1142 2 complications complication NNS cord-015365-iqdi99pd 1142 3 and and CC cord-015365-iqdi99pd 1142 4 recurrence recurrence NN cord-015365-iqdi99pd 1142 5 of of IN cord-015365-iqdi99pd 1142 6 underlying underlie VBG cord-015365-iqdi99pd 1142 7 disease disease NN cord-015365-iqdi99pd 1142 8 may may MD cord-015365-iqdi99pd 1142 9 be be VB cord-015365-iqdi99pd 1142 10 related relate VBN cord-015365-iqdi99pd 1142 11 to to IN cord-015365-iqdi99pd 1142 12 the the DT cord-015365-iqdi99pd 1142 13 primary primary JJ cord-015365-iqdi99pd 1142 14 disease disease NN cord-015365-iqdi99pd 1142 15 , , , cord-015365-iqdi99pd 1142 16 and and CC cord-015365-iqdi99pd 1142 17 an an DT cord-015365-iqdi99pd 1142 18 accurate accurate JJ cord-015365-iqdi99pd 1142 19 diagnosis diagnosis NN cord-015365-iqdi99pd 1142 20 is be VBZ cord-015365-iqdi99pd 1142 21 therefore therefore RB cord-015365-iqdi99pd 1142 22 essential essential JJ cord-015365-iqdi99pd 1142 23 . . . cord-015365-iqdi99pd 1143 1 Methods method NNS cord-015365-iqdi99pd 1143 2 . . . cord-015365-iqdi99pd 1144 1 A a DT cord-015365-iqdi99pd 1144 2 pathologic pathologic JJ cord-015365-iqdi99pd 1144 3 review review NN cord-015365-iqdi99pd 1144 4 was be VBD cord-015365-iqdi99pd 1144 5 performed perform VBN cord-015365-iqdi99pd 1144 6 on on IN cord-015365-iqdi99pd 1144 7 1056 1056 CD cord-015365-iqdi99pd 1144 8 primary primary JJ cord-015365-iqdi99pd 1144 9 lung lung NN cord-015365-iqdi99pd 1144 10 transplantations transplantation NNS cord-015365-iqdi99pd 1144 11 over over IN cord-015365-iqdi99pd 1144 12 a a DT cord-015365-iqdi99pd 1144 13 period period NN cord-015365-iqdi99pd 1144 14 of of IN cord-015365-iqdi99pd 1144 15 22 22 CD cord-015365-iqdi99pd 1144 16 years year NNS cord-015365-iqdi99pd 1144 17 ( ( -LRB- cord-015365-iqdi99pd 1144 18 1998 1998 CD cord-015365-iqdi99pd 1144 19 to to IN cord-015365-iqdi99pd 1144 20 2010 2010 CD cord-015365-iqdi99pd 1144 21 ) ) -RRB- cord-015365-iqdi99pd 1144 22 . . . cord-015365-iqdi99pd 1145 1 Diagnoses diagnosis NNS cord-015365-iqdi99pd 1145 2 of of IN cord-015365-iqdi99pd 1145 3 native native JJ cord-015365-iqdi99pd 1145 4 lungs lung NNS cord-015365-iqdi99pd 1145 5 were be VBD cord-015365-iqdi99pd 1145 6 compared compare VBN cord-015365-iqdi99pd 1145 7 with with IN cord-015365-iqdi99pd 1145 8 referral referral JJ cord-015365-iqdi99pd 1145 9 diagnoses diagnosis NNS cord-015365-iqdi99pd 1145 10 to to TO cord-015365-iqdi99pd 1145 11 assess assess VB cord-015365-iqdi99pd 1145 12 the the DT cord-015365-iqdi99pd 1145 13 presence presence NN cord-015365-iqdi99pd 1145 14 of of IN cord-015365-iqdi99pd 1145 15 discrepancies discrepancy NNS cord-015365-iqdi99pd 1145 16 or or CC cord-015365-iqdi99pd 1145 17 expanded expand VBN cord-015365-iqdi99pd 1145 18 results result NNS cord-015365-iqdi99pd 1145 19 like like IN cord-015365-iqdi99pd 1145 20 malignancies malignancy NNS cord-015365-iqdi99pd 1145 21 or or CC cord-015365-iqdi99pd 1145 22 infections infection NNS cord-015365-iqdi99pd 1145 23 . . . cord-015365-iqdi99pd 1146 1 Results result NNS cord-015365-iqdi99pd 1146 2 . . . cord-015365-iqdi99pd 1147 1 73 73 CD cord-015365-iqdi99pd 1147 2 ( ( -LRB- cord-015365-iqdi99pd 1147 3 7 7 CD cord-015365-iqdi99pd 1147 4 % % NN cord-015365-iqdi99pd 1147 5 ) ) -RRB- cord-015365-iqdi99pd 1147 6 cases case NNS cord-015365-iqdi99pd 1147 7 presented present VBD cord-015365-iqdi99pd 1147 8 a a DT cord-015365-iqdi99pd 1147 9 different different JJ cord-015365-iqdi99pd 1147 10 or or CC cord-015365-iqdi99pd 1147 11 expanded expand VBN cord-015365-iqdi99pd 1147 12 diagnosis diagnosis NN cord-015365-iqdi99pd 1147 13 . . . cord-015365-iqdi99pd 1148 1 Discrepancies discrepancy NNS cord-015365-iqdi99pd 1148 2 between between IN cord-015365-iqdi99pd 1148 3 referral referral JJ cord-015365-iqdi99pd 1148 4 diagnosis diagnosis NN cord-015365-iqdi99pd 1148 5 and and CC cord-015365-iqdi99pd 1148 6 histopathology histopathology NN cord-015365-iqdi99pd 1148 7 were be VBD cord-015365-iqdi99pd 1148 8 found find VBN cord-015365-iqdi99pd 1148 9 in in IN cord-015365-iqdi99pd 1148 10 34 34 CD cord-015365-iqdi99pd 1148 11 of of IN cord-015365-iqdi99pd 1148 12 1054 1054 CD cord-015365-iqdi99pd 1148 13 cases case NNS cord-015365-iqdi99pd 1148 14 ( ( -LRB- cord-015365-iqdi99pd 1148 15 3 3 CD cord-015365-iqdi99pd 1148 16 % % NN cord-015365-iqdi99pd 1148 17 ) ) -RRB- cord-015365-iqdi99pd 1148 18 . . . cord-015365-iqdi99pd 1149 1 The the DT cord-015365-iqdi99pd 1149 2 highest high JJS cord-015365-iqdi99pd 1149 3 percentage percentage NN cord-015365-iqdi99pd 1149 4 of of IN cord-015365-iqdi99pd 1149 5 discordance discordance NN cord-015365-iqdi99pd 1149 6 was be VBD cord-015365-iqdi99pd 1149 7 depicted depict VBN cord-015365-iqdi99pd 1149 8 in in IN cord-015365-iqdi99pd 1149 9 chronic chronic JJ cord-015365-iqdi99pd 1149 10 obstructive obstructive JJ cord-015365-iqdi99pd 1149 11 lung lung NN cord-015365-iqdi99pd 1149 12 diseases disease NNS cord-015365-iqdi99pd 1149 13 ( ( -LRB- cord-015365-iqdi99pd 1149 14 12 12 CD cord-015365-iqdi99pd 1149 15 of of IN cord-015365-iqdi99pd 1149 16 344 344 CD cord-015365-iqdi99pd 1149 17 ) ) -RRB- cord-015365-iqdi99pd 1149 18 , , , cord-015365-iqdi99pd 1149 19 with with IN cord-015365-iqdi99pd 1149 20 the the DT cord-015365-iqdi99pd 1149 21 final final JJ cord-015365-iqdi99pd 1149 22 diagnosis diagnosis NN cord-015365-iqdi99pd 1149 23 of of IN cord-015365-iqdi99pd 1149 24 UIP UIP NNP cord-015365-iqdi99pd 1149 25 ( ( -LRB- cord-015365-iqdi99pd 1149 26 n n NN cord-015365-iqdi99pd 1149 27 ¼ ¼ NNP cord-015365-iqdi99pd 1149 28 4 4 CD cord-015365-iqdi99pd 1149 29 ) ) -RRB- cord-015365-iqdi99pd 1149 30 , , , cord-015365-iqdi99pd 1149 31 chronic chronic JJ cord-015365-iqdi99pd 1149 32 interstitial interstitial JJ cord-015365-iqdi99pd 1149 33 fibrosis fibrosis NN cord-015365-iqdi99pd 1149 34 ( ( -LRB- cord-015365-iqdi99pd 1149 35 n n NNP cord-015365-iqdi99pd 1149 36 ¼ ¼ NNP cord-015365-iqdi99pd 1149 37 4 4 CD cord-015365-iqdi99pd 1149 38 ) ) -RRB- cord-015365-iqdi99pd 1149 39 , , , cord-015365-iqdi99pd 1149 40 silicosis silicosis NN cord-015365-iqdi99pd 1149 41 ( ( -LRB- cord-015365-iqdi99pd 1149 42 n n NN cord-015365-iqdi99pd 1149 43 ¼ ¼ NNP cord-015365-iqdi99pd 1149 44 2 2 CD cord-015365-iqdi99pd 1149 45 ) ) -RRB- cord-015365-iqdi99pd 1149 46 , , , cord-015365-iqdi99pd 1149 47 LAM LAM NNP cord-015365-iqdi99pd 1149 48 ( ( -LRB- cord-015365-iqdi99pd 1149 49 n n NN cord-015365-iqdi99pd 1149 50 ¼ ¼ NNP cord-015365-iqdi99pd 1149 51 1 1 CD cord-015365-iqdi99pd 1149 52 ) ) -RRB- cord-015365-iqdi99pd 1149 53 and and CC cord-015365-iqdi99pd 1149 54 sarcoidosis sarcoidosis NNP cord-015365-iqdi99pd 1149 55 ( ( -LRB- cord-015365-iqdi99pd 1149 56 n n CC cord-015365-iqdi99pd 1149 57 ¼ ¼ NNP cord-015365-iqdi99pd 1149 58 1 1 CD cord-015365-iqdi99pd 1149 59 ) ) -RRB- cord-015365-iqdi99pd 1149 60 . . . cord-015365-iqdi99pd 1150 1 16 16 CD cord-015365-iqdi99pd 1150 2 patients patient NNS cord-015365-iqdi99pd 1150 3 who who WP cord-015365-iqdi99pd 1150 4 were be VBD cord-015365-iqdi99pd 1150 5 referred refer VBN cord-015365-iqdi99pd 1150 6 with with IN cord-015365-iqdi99pd 1150 7 the the DT cord-015365-iqdi99pd 1150 8 diagnosis diagnosis NN cord-015365-iqdi99pd 1150 9 of of IN cord-015365-iqdi99pd 1150 10 an an DT cord-015365-iqdi99pd 1150 11 interstitial interstitial JJ cord-015365-iqdi99pd 1150 12 lung lung NN cord-015365-iqdi99pd 1150 13 disease disease NN cord-015365-iqdi99pd 1150 14 had have VBD cord-015365-iqdi99pd 1150 15 predominantly predominantly RB cord-015365-iqdi99pd 1150 16 emphysema emphysema NN cord-015365-iqdi99pd 1150 17 ( ( -LRB- cord-015365-iqdi99pd 1150 18 n n NN cord-015365-iqdi99pd 1150 19 ¼ ¼ NNP cord-015365-iqdi99pd 1150 20 12 12 CD cord-015365-iqdi99pd 1150 21 ) ) -RRB- cord-015365-iqdi99pd 1150 22 , , , cord-015365-iqdi99pd 1150 23 bronchiectasis bronchiectasis NNP cord-015365-iqdi99pd 1150 24 ( ( -LRB- cord-015365-iqdi99pd 1150 25 n n NN cord-015365-iqdi99pd 1150 26 ¼ ¼ NNP cord-015365-iqdi99pd 1150 27 2 2 CD cord-015365-iqdi99pd 1150 28 ) ) -RRB- cord-015365-iqdi99pd 1150 29 and and CC cord-015365-iqdi99pd 1150 30 histiocytosis histiocytosis NNP cord-015365-iqdi99pd 1150 31 X X NNP cord-015365-iqdi99pd 1150 32 ( ( -LRB- cord-015365-iqdi99pd 1150 33 n n NNP cord-015365-iqdi99pd 1150 34 ¼ ¼ NNP cord-015365-iqdi99pd 1150 35 2 2 CD cord-015365-iqdi99pd 1150 36 ) ) -RRB- cord-015365-iqdi99pd 1150 37 . . . cord-015365-iqdi99pd 1151 1 Expanded expand VBN cord-015365-iqdi99pd 1151 2 results result NNS cord-015365-iqdi99pd 1151 3 included include VBD cord-015365-iqdi99pd 1151 4 Aspergillus aspergillus NN cord-015365-iqdi99pd 1151 5 ( ( -LRB- cord-015365-iqdi99pd 1151 6 n n NN cord-015365-iqdi99pd 1151 7 ¼ ¼ NNP cord-015365-iqdi99pd 1151 8 11 11 CD cord-015365-iqdi99pd 1151 9 ) ) -RRB- cord-015365-iqdi99pd 1151 10 and and CC cord-015365-iqdi99pd 1151 11 mycobacterial mycobacterial NNP cord-015365-iqdi99pd 1151 12 ( ( -LRB- cord-015365-iqdi99pd 1151 13 n n NN cord-015365-iqdi99pd 1151 14 ¼ ¼ NNP cord-015365-iqdi99pd 1151 15 16 16 CD cord-015365-iqdi99pd 1151 16 ) ) -RRB- cord-015365-iqdi99pd 1151 17 infections infection NNS cord-015365-iqdi99pd 1151 18 , , , cord-015365-iqdi99pd 1151 19 carcinomas carcinoma NNS cord-015365-iqdi99pd 1151 20 ( ( -LRB- cord-015365-iqdi99pd 1151 21 n n NN cord-015365-iqdi99pd 1151 22 ¼ ¼ NNP cord-015365-iqdi99pd 1151 23 10 10 CD cord-015365-iqdi99pd 1151 24 ) ) -RRB- cord-015365-iqdi99pd 1151 25 , , , cord-015365-iqdi99pd 1151 26 cystic cystic JJ cord-015365-iqdi99pd 1151 27 adenomatoid adenomatoid NNP cord-015365-iqdi99pd 1151 28 dysplasia dysplasia NNP cord-015365-iqdi99pd 1151 29 ( ( -LRB- cord-015365-iqdi99pd 1151 30 n n NNP cord-015365-iqdi99pd 1151 31 ¼ ¼ NNP cord-015365-iqdi99pd 1151 32 1 1 CD cord-015365-iqdi99pd 1151 33 ) ) -RRB- cord-015365-iqdi99pd 1151 34 and and CC cord-015365-iqdi99pd 1151 35 carcinoid carcinoid NNP cord-015365-iqdi99pd 1151 36 ( ( -LRB- cord-015365-iqdi99pd 1151 37 n n NNP cord-015365-iqdi99pd 1151 38 ¼ ¼ NNP cord-015365-iqdi99pd 1151 39 1 1 CD cord-015365-iqdi99pd 1151 40 ) ) -RRB- cord-015365-iqdi99pd 1151 41 . . . cord-015365-iqdi99pd 1152 1 However however RB cord-015365-iqdi99pd 1152 2 , , , cord-015365-iqdi99pd 1152 3 short short JJ cord-015365-iqdi99pd 1152 4 - - HYPH cord-015365-iqdi99pd 1152 5 and and CC cord-015365-iqdi99pd 1152 6 long long JJ cord-015365-iqdi99pd 1152 7 - - HYPH cord-015365-iqdi99pd 1152 8 term term NN cord-015365-iqdi99pd 1152 9 survival survival NN cord-015365-iqdi99pd 1152 10 was be VBD cord-015365-iqdi99pd 1152 11 not not RB cord-015365-iqdi99pd 1152 12 different different JJ cord-015365-iqdi99pd 1152 13 in in IN cord-015365-iqdi99pd 1152 14 patients patient NNS cord-015365-iqdi99pd 1152 15 with with IN cord-015365-iqdi99pd 1152 16 different different JJ cord-015365-iqdi99pd 1152 17 diagnoses diagnosis NNS cord-015365-iqdi99pd 1152 18 , , , cord-015365-iqdi99pd 1152 19 malignancies malignancy NNS cord-015365-iqdi99pd 1152 20 or or CC cord-015365-iqdi99pd 1152 21 implanted implant VBN cord-015365-iqdi99pd 1152 22 infections infection NNS cord-015365-iqdi99pd 1152 23 . . . cord-015365-iqdi99pd 1153 1 Interestingly interestingly RB cord-015365-iqdi99pd 1153 2 all all DT cord-015365-iqdi99pd 1153 3 mycobacterial mycobacterial JJ cord-015365-iqdi99pd 1153 4 infections infection NNS cord-015365-iqdi99pd 1153 5 and and CC cord-015365-iqdi99pd 1153 6 all all DT cord-015365-iqdi99pd 1153 7 malignancies malignancy NNS cord-015365-iqdi99pd 1153 8 occurred occur VBD cord-015365-iqdi99pd 1153 9 in in IN cord-015365-iqdi99pd 1153 10 patients patient NNS cord-015365-iqdi99pd 1153 11 with with IN cord-015365-iqdi99pd 1153 12 COPD COPD NNP cord-015365-iqdi99pd 1153 13 . . . cord-015365-iqdi99pd 1154 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1154 2 . . . cord-015365-iqdi99pd 1155 1 On on IN cord-015365-iqdi99pd 1155 2 account account NN cord-015365-iqdi99pd 1155 3 of of IN cord-015365-iqdi99pd 1155 4 this this DT cord-015365-iqdi99pd 1155 5 high high JJ cord-015365-iqdi99pd 1155 6 rate rate NN cord-015365-iqdi99pd 1155 7 of of IN cord-015365-iqdi99pd 1155 8 discrepancies discrepancy NNS cord-015365-iqdi99pd 1155 9 and and CC cord-015365-iqdi99pd 1155 10 its -PRON- PRP$ cord-015365-iqdi99pd 1155 11 possible possible JJ cord-015365-iqdi99pd 1155 12 influence influence NN cord-015365-iqdi99pd 1155 13 on on IN cord-015365-iqdi99pd 1155 14 survival survival NN cord-015365-iqdi99pd 1155 15 , , , cord-015365-iqdi99pd 1155 16 frequently frequently RB cord-015365-iqdi99pd 1155 17 repeated repeat VBD cord-015365-iqdi99pd 1155 18 clinicopathologic clinicopathologic JJ cord-015365-iqdi99pd 1155 19 investigations investigation NNS cord-015365-iqdi99pd 1155 20 should should MD cord-015365-iqdi99pd 1155 21 be be VB cord-015365-iqdi99pd 1155 22 performed perform VBN cord-015365-iqdi99pd 1155 23 during during IN cord-015365-iqdi99pd 1155 24 the the DT cord-015365-iqdi99pd 1155 25 waiting waiting NN cord-015365-iqdi99pd 1155 26 list list NN cord-015365-iqdi99pd 1155 27 period period NN cord-015365-iqdi99pd 1155 28 . . . cord-015365-iqdi99pd 1155 29 _SP cord-015365-iqdi99pd 1156 1 Background background NN cord-015365-iqdi99pd 1156 2 . . . cord-015365-iqdi99pd 1157 1 Induction induction NN cord-015365-iqdi99pd 1157 2 therapy therapy NN cord-015365-iqdi99pd 1157 3 with with IN cord-015365-iqdi99pd 1157 4 alemtuzumab alemtuzumab NNP cord-015365-iqdi99pd 1157 5 , , , cord-015365-iqdi99pd 1157 6 followed follow VBN cord-015365-iqdi99pd 1157 7 by by IN cord-015365-iqdi99pd 1157 8 lower low JJR cord-015365-iqdi99pd 1157 9 than than IN cord-015365-iqdi99pd 1157 10 conventional conventional JJ cord-015365-iqdi99pd 1157 11 intensity intensity NN cord-015365-iqdi99pd 1157 12 post post JJ cord-015365-iqdi99pd 1157 13 - - JJ cord-015365-iqdi99pd 1157 14 transplant transplant JJ cord-015365-iqdi99pd 1157 15 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1157 16 , , , cord-015365-iqdi99pd 1157 17 has have VBZ cord-015365-iqdi99pd 1157 18 been be VBN cord-015365-iqdi99pd 1157 19 associated associate VBN cord-015365-iqdi99pd 1157 20 with with IN cord-015365-iqdi99pd 1157 21 reduced reduce VBN cord-015365-iqdi99pd 1157 22 morbidity morbidity NN cord-015365-iqdi99pd 1157 23 and and CC cord-015365-iqdi99pd 1157 24 mortality mortality NN cord-015365-iqdi99pd 1157 25 in in IN cord-015365-iqdi99pd 1157 26 abdominal abdominal JJ cord-015365-iqdi99pd 1157 27 and and CC cord-015365-iqdi99pd 1157 28 heart heart NN cord-015365-iqdi99pd 1157 29 transplantation transplantation NN cord-015365-iqdi99pd 1157 30 . . . cord-015365-iqdi99pd 1158 1 We -PRON- PRP cord-015365-iqdi99pd 1158 2 performed perform VBD cord-015365-iqdi99pd 1158 3 a a DT cord-015365-iqdi99pd 1158 4 prospective prospective JJ cord-015365-iqdi99pd 1158 5 randomized randomized JJ cord-015365-iqdi99pd 1158 6 trial trial NN cord-015365-iqdi99pd 1158 7 in in IN cord-015365-iqdi99pd 1158 8 lung lung NN cord-015365-iqdi99pd 1158 9 recipients recipient NNS cord-015365-iqdi99pd 1158 10 receiving receive VBG cord-015365-iqdi99pd 1158 11 alemtuzumab alemtuzumab NNS cord-015365-iqdi99pd 1158 12 in in IN cord-015365-iqdi99pd 1158 13 conjunction conjunction NN cord-015365-iqdi99pd 1158 14 with with IN cord-015365-iqdi99pd 1158 15 reduced reduce VBN cord-015365-iqdi99pd 1158 16 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1158 17 compared compare VBN cord-015365-iqdi99pd 1158 18 with with IN cord-015365-iqdi99pd 1158 19 patients patient NNS cord-015365-iqdi99pd 1158 20 receiving receive VBG cord-015365-iqdi99pd 1158 21 thymoglobulin thymoglobulin NNP cord-015365-iqdi99pd 1158 22 in in IN cord-015365-iqdi99pd 1158 23 association association NN cord-015365-iqdi99pd 1158 24 with with IN cord-015365-iqdi99pd 1158 25 routinely routinely RB cord-015365-iqdi99pd 1158 26 dosed dose VBN cord-015365-iqdi99pd 1158 27 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1158 28 . . . cord-015365-iqdi99pd 1159 1 Methods method NNS cord-015365-iqdi99pd 1159 2 . . . cord-015365-iqdi99pd 1160 1 60 60 CD cord-015365-iqdi99pd 1160 2 lung lung NN cord-015365-iqdi99pd 1160 3 TX TX NNP cord-015365-iqdi99pd 1160 4 recipients recipient NNS cord-015365-iqdi99pd 1160 5 were be VBD cord-015365-iqdi99pd 1160 6 prospectively prospectively RB cord-015365-iqdi99pd 1160 7 randomized randomize VBN cord-015365-iqdi99pd 1160 8 in in IN cord-015365-iqdi99pd 1160 9 two two CD cord-015365-iqdi99pd 1160 10 groups group NNS cord-015365-iqdi99pd 1160 11 : : : cord-015365-iqdi99pd 1160 12 group group NN cord-015365-iqdi99pd 1160 13 A a DT cord-015365-iqdi99pd 1160 14 received receive VBD cord-015365-iqdi99pd 1160 15 alemtuzumab alemtuzumab NNS cord-015365-iqdi99pd 1160 16 in in IN cord-015365-iqdi99pd 1160 17 conjunction conjunction NN cord-015365-iqdi99pd 1160 18 with with IN cord-015365-iqdi99pd 1160 19 early early JJ cord-015365-iqdi99pd 1160 20 lower low JJR cord-015365-iqdi99pd 1160 21 - - HYPH cord-015365-iqdi99pd 1160 22 dose dose NN cord-015365-iqdi99pd 1160 23 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1160 24 , , , cord-015365-iqdi99pd 1160 25 lower low JJR cord-015365-iqdi99pd 1160 26 - - HYPH cord-015365-iqdi99pd 1160 27 dose dose NN cord-015365-iqdi99pd 1160 28 steroids steroid NNS cord-015365-iqdi99pd 1160 29 , , , cord-015365-iqdi99pd 1160 30 and and CC cord-015365-iqdi99pd 1160 31 half half JJ cord-015365-iqdi99pd 1160 32 - - HYPH cord-015365-iqdi99pd 1160 33 dose dose NN cord-015365-iqdi99pd 1160 34 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 1160 35 mofetil mofetil NNP cord-015365-iqdi99pd 1160 36 , , , cord-015365-iqdi99pd 1160 37 compared compare VBN cord-015365-iqdi99pd 1160 38 with with IN cord-015365-iqdi99pd 1160 39 group group NN cord-015365-iqdi99pd 1160 40 B b NN cord-015365-iqdi99pd 1160 41 receiving receive VBG cord-015365-iqdi99pd 1160 42 thymoglobulin thymoglobulin NNP cord-015365-iqdi99pd 1160 43 in in IN cord-015365-iqdi99pd 1160 44 association association NN cord-015365-iqdi99pd 1160 45 with with IN cord-015365-iqdi99pd 1160 46 routinely routinely RB cord-015365-iqdi99pd 1160 47 dosed dose VBN cord-015365-iqdi99pd 1160 48 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1160 49 . . . cord-015365-iqdi99pd 1161 1 Survival survival NN cord-015365-iqdi99pd 1161 2 analyses analysis NNS cord-015365-iqdi99pd 1161 3 examined examine VBD cord-015365-iqdi99pd 1161 4 patient patient JJ cord-015365-iqdi99pd 1161 5 and and CC cord-015365-iqdi99pd 1161 6 graft graft NN cord-015365-iqdi99pd 1161 7 survival survival NN cord-015365-iqdi99pd 1161 8 , , , cord-015365-iqdi99pd 1161 9 freedom freedom NN cord-015365-iqdi99pd 1161 10 from from IN cord-015365-iqdi99pd 1161 11 acute acute JJ cord-015365-iqdi99pd 1161 12 cellular cellular JJ cord-015365-iqdi99pd 1161 13 rejection rejection NN cord-015365-iqdi99pd 1161 14 ( ( -LRB- cord-015365-iqdi99pd 1161 15 ACR ACR NNP cord-015365-iqdi99pd 1161 16 ) ) -RRB- cord-015365-iqdi99pd 1161 17 , , , cord-015365-iqdi99pd 1161 18 lymphocytic lymphocytic JJ cord-015365-iqdi99pd 1161 19 bronchiolitis bronchiolitis NN cord-015365-iqdi99pd 1161 20 , , , cord-015365-iqdi99pd 1161 21 bronchiolitis bronchiolitis NNP cord-015365-iqdi99pd 1161 22 obliterans obliterans NNP cord-015365-iqdi99pd 1161 23 syndrome syndrome NNP cord-015365-iqdi99pd 1161 24 ( ( -LRB- cord-015365-iqdi99pd 1161 25 BOS BOS NNP cord-015365-iqdi99pd 1161 26 ) ) -RRB- cord-015365-iqdi99pd 1161 27 , , , cord-015365-iqdi99pd 1161 28 kidney kidney NN cord-015365-iqdi99pd 1161 29 function function NN cord-015365-iqdi99pd 1161 30 , , , cord-015365-iqdi99pd 1161 31 infectious infectious JJ cord-015365-iqdi99pd 1161 32 complications complication NNS cord-015365-iqdi99pd 1161 33 and and CC cord-015365-iqdi99pd 1161 34 post post JJ cord-015365-iqdi99pd 1161 35 - - JJ cord-015365-iqdi99pd 1161 36 transplant transplant JJ cord-015365-iqdi99pd 1161 37 lymphoproliferative lymphoproliferative JJ cord-015365-iqdi99pd 1161 38 disorder disorder NN cord-015365-iqdi99pd 1161 39 ( ( -LRB- cord-015365-iqdi99pd 1161 40 PTLD PTLD NNP cord-015365-iqdi99pd 1161 41 ) ) -RRB- cord-015365-iqdi99pd 1161 42 . . . cord-015365-iqdi99pd 1162 1 Results result NNS cord-015365-iqdi99pd 1162 2 . . . cord-015365-iqdi99pd 1163 1 There there EX cord-015365-iqdi99pd 1163 2 were be VBD cord-015365-iqdi99pd 1163 3 no no DT cord-015365-iqdi99pd 1163 4 significant significant JJ cord-015365-iqdi99pd 1163 5 differences difference NNS cord-015365-iqdi99pd 1163 6 in in IN cord-015365-iqdi99pd 1163 7 6-and 6-and CD cord-015365-iqdi99pd 1163 8 12month 12month JJ cord-015365-iqdi99pd 1163 9 survival survival NN cord-015365-iqdi99pd 1163 10 ( ( -LRB- cord-015365-iqdi99pd 1163 11 alemtuzumab alemtuzumab VBN cord-015365-iqdi99pd 1163 12 96 96 CD cord-015365-iqdi99pd 1163 13 % % NN cord-015365-iqdi99pd 1163 14 vs. vs. IN cord-015365-iqdi99pd 1163 15 ATG ATG NNP cord-015365-iqdi99pd 1163 16 93 93 CD cord-015365-iqdi99pd 1163 17 % % NN cord-015365-iqdi99pd 1163 18 and and CC cord-015365-iqdi99pd 1163 19 93 93 CD cord-015365-iqdi99pd 1163 20 % % NN cord-015365-iqdi99pd 1163 21 vs. vs. IN cord-015365-iqdi99pd 1163 22 96 96 CD cord-015365-iqdi99pd 1163 23 % % NN cord-015365-iqdi99pd 1163 24 , , , cord-015365-iqdi99pd 1163 25 respectively respectively RB cord-015365-iqdi99pd 1163 26 , , , cord-015365-iqdi99pd 1163 27 p p NN cord-015365-iqdi99pd 1163 28 ¼ ¼ CD cord-015365-iqdi99pd 1163 29 NS NS NNP cord-015365-iqdi99pd 1163 30 ) ) -RRB- cord-015365-iqdi99pd 1163 31 . . . cord-015365-iqdi99pd 1164 1 Acute acute JJ cord-015365-iqdi99pd 1164 2 cellular cellular JJ cord-015365-iqdi99pd 1164 3 rejection rejection NN cord-015365-iqdi99pd 1164 4 episodes episode NNS cord-015365-iqdi99pd 1165 1 ¼ ¼ NNP cord-015365-iqdi99pd 1165 2 A2 A2 NNP cord-015365-iqdi99pd 1165 3 within within IN cord-015365-iqdi99pd 1165 4 the the DT cord-015365-iqdi99pd 1165 5 first first JJ cord-015365-iqdi99pd 1165 6 TX TX NNP cord-015365-iqdi99pd 1165 7 year year NN cord-015365-iqdi99pd 1165 8 were be VBD cord-015365-iqdi99pd 1165 9 significant significant JJ cord-015365-iqdi99pd 1165 10 lower lower RBR cord-015365-iqdi99pd 1165 11 in in IN cord-015365-iqdi99pd 1165 12 group group NN cord-015365-iqdi99pd 1165 13 A A NNP cord-015365-iqdi99pd 1165 14 ( ( -LRB- cord-015365-iqdi99pd 1165 15 alemtuzumab alemtuzumab JJ cord-015365-iqdi99pd 1165 16 0 0 CD cord-015365-iqdi99pd 1165 17 vs. vs. IN cord-015365-iqdi99pd 1165 18 ATG ATG NNP cord-015365-iqdi99pd 1165 19 0,33 0,33 NNP cord-015365-iqdi99pd 1165 20 ; ; : cord-015365-iqdi99pd 1165 21 p p NN cord-015365-iqdi99pd 1165 22 ¼ ¼ CD cord-015365-iqdi99pd 1165 23 0.019 0.019 CD cord-015365-iqdi99pd 1165 24 ) ) -RRB- cord-015365-iqdi99pd 1165 25 , , , cord-015365-iqdi99pd 1165 26 lymphocytic lymphocytic JJ cord-015365-iqdi99pd 1165 27 bronchiolitis bronchiolitis NN cord-015365-iqdi99pd 1165 28 was be VBD cord-015365-iqdi99pd 1165 29 not not RB cord-015365-iqdi99pd 1165 30 different different JJ cord-015365-iqdi99pd 1165 31 between between IN cord-015365-iqdi99pd 1165 32 the the DT cord-015365-iqdi99pd 1165 33 groups group NNS cord-015365-iqdi99pd 1165 34 ( ( -LRB- cord-015365-iqdi99pd 1165 35 cumulative cumulative JJ cord-015365-iqdi99pd 1165 36 B b NN cord-015365-iqdi99pd 1165 37 scores score NNS cord-015365-iqdi99pd 1165 38 group group NN cord-015365-iqdi99pd 1165 39 A a DT cord-015365-iqdi99pd 1165 40 2.9 2.9 CD cord-015365-iqdi99pd 1165 41 AE AE NNP cord-015365-iqdi99pd 1165 42 2.7 2.7 CD cord-015365-iqdi99pd 1165 43 vs. vs. NN cord-015365-iqdi99pd 1165 44 group group NN cord-015365-iqdi99pd 1165 45 B B NNP cord-015365-iqdi99pd 1165 46 3.2 3.2 CD cord-015365-iqdi99pd 1165 47 AE AE NNP cord-015365-iqdi99pd 1165 48 2.3 2.3 CD cord-015365-iqdi99pd 1165 49 per per IN cord-015365-iqdi99pd 1165 50 patient patient NN cord-015365-iqdi99pd 1165 51 , , , cord-015365-iqdi99pd 1165 52 p p NN cord-015365-iqdi99pd 1165 53 ¼ ¼ CD cord-015365-iqdi99pd 1165 54 0.74 0.74 CD cord-015365-iqdi99pd 1165 55 ) ) -RRB- cord-015365-iqdi99pd 1165 56 . . . cord-015365-iqdi99pd 1166 1 There there EX cord-015365-iqdi99pd 1166 2 were be VBD cord-015365-iqdi99pd 1166 3 no no DT cord-015365-iqdi99pd 1166 4 significant significant JJ cord-015365-iqdi99pd 1166 5 differences difference NNS cord-015365-iqdi99pd 1166 6 in in IN cord-015365-iqdi99pd 1166 7 bacterial bacterial JJ cord-015365-iqdi99pd 1166 8 ( ( -LRB- cord-015365-iqdi99pd 1166 9 group group NN cord-015365-iqdi99pd 1166 10 A a DT cord-015365-iqdi99pd 1166 11 2 2 CD cord-015365-iqdi99pd 1166 12 . . . cord-015365-iqdi99pd 1167 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1167 2 . . . cord-015365-iqdi99pd 1168 1 Alemtuzumab alemtuzumab JJ cord-015365-iqdi99pd 1168 2 induction induction NN cord-015365-iqdi99pd 1168 3 in in IN cord-015365-iqdi99pd 1168 4 conjunction conjunction NN cord-015365-iqdi99pd 1168 5 with with IN cord-015365-iqdi99pd 1168 6 reduced reduce VBN cord-015365-iqdi99pd 1168 7 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1168 8 significantly significantly RB cord-015365-iqdi99pd 1168 9 reduces reduce VBZ cord-015365-iqdi99pd 1168 10 higher high JJR cord-015365-iqdi99pd 1168 11 grade grade NN cord-015365-iqdi99pd 1168 12 rejection rejection NN cord-015365-iqdi99pd 1168 13 rates rate NNS cord-015365-iqdi99pd 1168 14 with with IN cord-015365-iqdi99pd 1168 15 comparable comparable JJ cord-015365-iqdi99pd 1168 16 survival survival NN cord-015365-iqdi99pd 1168 17 results result NNS cord-015365-iqdi99pd 1168 18 and and CC cord-015365-iqdi99pd 1168 19 infectious infectious JJ cord-015365-iqdi99pd 1168 20 complications complication NNS cord-015365-iqdi99pd 1168 21 to to IN cord-015365-iqdi99pd 1168 22 high high JJ cord-015365-iqdi99pd 1168 23 - - HYPH cord-015365-iqdi99pd 1168 24 dose dose NN cord-015365-iqdi99pd 1168 25 standard standard JJ cord-015365-iqdi99pd 1168 26 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1168 27 . . . cord-015365-iqdi99pd 1169 1 The the DT cord-015365-iqdi99pd 1169 2 incidence incidence NN cord-015365-iqdi99pd 1169 3 of of IN cord-015365-iqdi99pd 1169 4 early early JJ cord-015365-iqdi99pd 1169 5 BOS BOS NNP cord-015365-iqdi99pd 1169 6 was be VBD cord-015365-iqdi99pd 1169 7 higher high JJR cord-015365-iqdi99pd 1169 8 after after IN cord-015365-iqdi99pd 1169 9 alemtuzumab alemtuzumab JJ cord-015365-iqdi99pd 1169 10 - - HYPH cord-015365-iqdi99pd 1169 11 induction induction NN cord-015365-iqdi99pd 1169 12 . . . cord-015365-iqdi99pd 1170 1 Background background NN cord-015365-iqdi99pd 1170 2 . . . cord-015365-iqdi99pd 1171 1 Cardiac cardiac JJ cord-015365-iqdi99pd 1171 2 allograft allograft NN cord-015365-iqdi99pd 1171 3 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 1171 4 ( ( -LRB- cord-015365-iqdi99pd 1171 5 CAV CAV NNP cord-015365-iqdi99pd 1171 6 ) ) -RRB- cord-015365-iqdi99pd 1171 7 is be VBZ cord-015365-iqdi99pd 1171 8 a a DT cord-015365-iqdi99pd 1171 9 major major JJ cord-015365-iqdi99pd 1171 10 cause cause NN cord-015365-iqdi99pd 1171 11 of of IN cord-015365-iqdi99pd 1171 12 allograft allograft NN cord-015365-iqdi99pd 1171 13 failure failure NN cord-015365-iqdi99pd 1171 14 in in IN cord-015365-iqdi99pd 1171 15 long long JJ cord-015365-iqdi99pd 1171 16 - - HYPH cord-015365-iqdi99pd 1171 17 term term NN cord-015365-iqdi99pd 1171 18 heart heart NN cord-015365-iqdi99pd 1171 19 transplant transplant NN cord-015365-iqdi99pd 1171 20 patients patient NNS cord-015365-iqdi99pd 1171 21 . . . cord-015365-iqdi99pd 1172 1 Even even RB cord-015365-iqdi99pd 1172 2 without without IN cord-015365-iqdi99pd 1172 3 typical typical JJ cord-015365-iqdi99pd 1172 4 angina angina NN cord-015365-iqdi99pd 1172 5 symptoms symptom NNS cord-015365-iqdi99pd 1172 6 and and CC cord-015365-iqdi99pd 1172 7 diffuse diffuse JJ cord-015365-iqdi99pd 1172 8 lesions lesion NNS cord-015365-iqdi99pd 1172 9 , , , cord-015365-iqdi99pd 1172 10 CAV CAV NNP cord-015365-iqdi99pd 1172 11 resembles resemble VBZ cord-015365-iqdi99pd 1172 12 atherosclerosis atherosclerosis NN cord-015365-iqdi99pd 1172 13 , , , cord-015365-iqdi99pd 1172 14 but but CC cord-015365-iqdi99pd 1172 15 shows show VBZ cord-015365-iqdi99pd 1172 16 more more RBR cord-015365-iqdi99pd 1172 17 concentric concentric JJ cord-015365-iqdi99pd 1172 18 rather rather RB cord-015365-iqdi99pd 1172 19 than than IN cord-015365-iqdi99pd 1172 20 eccentric eccentric JJ cord-015365-iqdi99pd 1172 21 intimal intimal JJ cord-015365-iqdi99pd 1172 22 proliferation proliferation NN cord-015365-iqdi99pd 1172 23 . . . cord-015365-iqdi99pd 1173 1 Both both DT cord-015365-iqdi99pd 1173 2 , , , cord-015365-iqdi99pd 1173 3 proximal proximal JJ cord-015365-iqdi99pd 1173 4 and and CC cord-015365-iqdi99pd 1173 5 distal distal JJ cord-015365-iqdi99pd 1173 6 portions portion NNS cord-015365-iqdi99pd 1173 7 of of IN cord-015365-iqdi99pd 1173 8 the the DT cord-015365-iqdi99pd 1173 9 coronary coronary JJ cord-015365-iqdi99pd 1173 10 tree tree NN cord-015365-iqdi99pd 1173 11 are be VBP cord-015365-iqdi99pd 1173 12 involved involve VBN cord-015365-iqdi99pd 1173 13 . . . cord-015365-iqdi99pd 1174 1 Cardiac cardiac JJ cord-015365-iqdi99pd 1174 2 angiographies angiography NNS cord-015365-iqdi99pd 1174 3 are be VBP cord-015365-iqdi99pd 1174 4 periodically periodically RB cord-015365-iqdi99pd 1174 5 performed perform VBN cord-015365-iqdi99pd 1174 6 in in IN cord-015365-iqdi99pd 1174 7 the the DT cord-015365-iqdi99pd 1174 8 routine routine JJ cord-015365-iqdi99pd 1174 9 long long JJ cord-015365-iqdi99pd 1174 10 - - HYPH cord-015365-iqdi99pd 1174 11 term term NN cord-015365-iqdi99pd 1174 12 follow follow VB cord-015365-iqdi99pd 1174 13 up up RP cord-015365-iqdi99pd 1174 14 after after IN cord-015365-iqdi99pd 1174 15 heart heart NN cord-015365-iqdi99pd 1174 16 transplantation transplantation NN cord-015365-iqdi99pd 1174 17 . . . cord-015365-iqdi99pd 1175 1 Methods method NNS cord-015365-iqdi99pd 1175 2 . . . cord-015365-iqdi99pd 1176 1 Cardiac cardiac JJ cord-015365-iqdi99pd 1176 2 angiographies angiography NNS cord-015365-iqdi99pd 1176 3 and and CC cord-015365-iqdi99pd 1176 4 interventions intervention NNS cord-015365-iqdi99pd 1176 5 have have VBP cord-015365-iqdi99pd 1176 6 been be VBN cord-015365-iqdi99pd 1176 7 performed perform VBN cord-015365-iqdi99pd 1176 8 on on IN cord-015365-iqdi99pd 1176 9 19 19 CD cord-015365-iqdi99pd 1176 10 patients patient NNS cord-015365-iqdi99pd 1176 11 ( ( -LRB- cord-015365-iqdi99pd 1176 12 17 17 CD cord-015365-iqdi99pd 1176 13 male male NN cord-015365-iqdi99pd 1176 14 and and CC cord-015365-iqdi99pd 1176 15 2 2 CD cord-015365-iqdi99pd 1176 16 female female NN cord-015365-iqdi99pd 1176 17 ) ) -RRB- cord-015365-iqdi99pd 1176 18 without without IN cord-015365-iqdi99pd 1176 19 any any DT cord-015365-iqdi99pd 1176 20 complications complication NNS cord-015365-iqdi99pd 1176 21 and and CC cord-015365-iqdi99pd 1176 22 substantial substantial JJ cord-015365-iqdi99pd 1176 23 advantage advantage NN cord-015365-iqdi99pd 1176 24 in in IN cord-015365-iqdi99pd 1176 25 this this DT cord-015365-iqdi99pd 1176 26 cohort cohort NN cord-015365-iqdi99pd 1176 27 of of IN cord-015365-iqdi99pd 1176 28 patients patient NNS cord-015365-iqdi99pd 1176 29 . . . cord-015365-iqdi99pd 1177 1 6 6 CD cord-015365-iqdi99pd 1177 2 Patients patient NNS cord-015365-iqdi99pd 1177 3 already already RB cord-015365-iqdi99pd 1177 4 had have VBD cord-015365-iqdi99pd 1177 5 previous previous JJ cord-015365-iqdi99pd 1177 6 interventions intervention NNS cord-015365-iqdi99pd 1177 7 . . . cord-015365-iqdi99pd 1178 1 Mean mean JJ cord-015365-iqdi99pd 1178 2 time time NN cord-015365-iqdi99pd 1178 3 after after IN cord-015365-iqdi99pd 1178 4 transplantation transplantation NN cord-015365-iqdi99pd 1178 5 was be VBD cord-015365-iqdi99pd 1178 6 11.4 11.4 CD cord-015365-iqdi99pd 1178 7 AE AE NNP cord-015365-iqdi99pd 1178 8 5.8 5.8 CD cord-015365-iqdi99pd 1178 9 years year NNS cord-015365-iqdi99pd 1178 10 . . . cord-015365-iqdi99pd 1179 1 Results result NNS cord-015365-iqdi99pd 1179 2 . . . cord-015365-iqdi99pd 1180 1 Follow follow VB cord-015365-iqdi99pd 1180 2 - - HYPH cord-015365-iqdi99pd 1180 3 up up RP cord-015365-iqdi99pd 1180 4 angiography angiography NN cord-015365-iqdi99pd 1180 5 showed show VBD cord-015365-iqdi99pd 1180 6 no no DT cord-015365-iqdi99pd 1180 7 in in IN cord-015365-iqdi99pd 1180 8 - - HYPH cord-015365-iqdi99pd 1180 9 stent stent NN cord-015365-iqdi99pd 1180 10 restenosis restenosis NN cord-015365-iqdi99pd 1180 11 in in IN cord-015365-iqdi99pd 1180 12 the the DT cord-015365-iqdi99pd 1180 13 patients patient NNS cord-015365-iqdi99pd 1180 14 with with IN cord-015365-iqdi99pd 1180 15 previous previous JJ cord-015365-iqdi99pd 1180 16 interventions intervention NNS cord-015365-iqdi99pd 1180 17 after after IN cord-015365-iqdi99pd 1180 18 a a DT cord-015365-iqdi99pd 1180 19 mean mean JJ cord-015365-iqdi99pd 1180 20 time time NN cord-015365-iqdi99pd 1180 21 of of IN cord-015365-iqdi99pd 1180 22 36 36 CD cord-015365-iqdi99pd 1180 23 AE AE NNP cord-015365-iqdi99pd 1180 24 18 18 CD cord-015365-iqdi99pd 1180 25 months month NNS cord-015365-iqdi99pd 1180 26 . . . cord-015365-iqdi99pd 1181 1 3 3 CD cord-015365-iqdi99pd 1181 2 patients patient NNS cord-015365-iqdi99pd 1181 3 were be VBD cord-015365-iqdi99pd 1181 4 in in IN cord-015365-iqdi99pd 1181 5 need need NN cord-015365-iqdi99pd 1181 6 of of IN cord-015365-iqdi99pd 1181 7 interventions intervention NNS cord-015365-iqdi99pd 1181 8 , , , cord-015365-iqdi99pd 1181 9 2 2 CD cord-015365-iqdi99pd 1181 10 of of IN cord-015365-iqdi99pd 1181 11 them -PRON- PRP cord-015365-iqdi99pd 1181 12 in in IN cord-015365-iqdi99pd 1181 13 LADp3 LADp3 NNP cord-015365-iqdi99pd 1181 14 with with IN cord-015365-iqdi99pd 1181 15 endeavour endeavour NN cord-015365-iqdi99pd 1181 16 stents stent NNS cord-015365-iqdi99pd 1181 17 and and CC cord-015365-iqdi99pd 1181 18 1 1 CD cord-015365-iqdi99pd 1181 19 patient patient NN cord-015365-iqdi99pd 1181 20 in in IN cord-015365-iqdi99pd 1181 21 RCA1 RCA1 NNP cord-015365-iqdi99pd 1181 22 with with IN cord-015365-iqdi99pd 1181 23 cypher cypher NN cord-015365-iqdi99pd 1181 24 stent stent NN cord-015365-iqdi99pd 1181 25 . . . cord-015365-iqdi99pd 1182 1 No no DT cord-015365-iqdi99pd 1182 2 complications complication NNS cord-015365-iqdi99pd 1182 3 have have VBP cord-015365-iqdi99pd 1182 4 been be VBN cord-015365-iqdi99pd 1182 5 observed observe VBN cord-015365-iqdi99pd 1182 6 . . . cord-015365-iqdi99pd 1183 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1183 2 . . . cord-015365-iqdi99pd 1184 1 Radial radial JJ cord-015365-iqdi99pd 1184 2 angiography angiography NN cord-015365-iqdi99pd 1184 3 is be VBZ cord-015365-iqdi99pd 1184 4 a a DT cord-015365-iqdi99pd 1184 5 safer safe JJR cord-015365-iqdi99pd 1184 6 method method NN cord-015365-iqdi99pd 1184 7 for for IN cord-015365-iqdi99pd 1184 8 routine routine JJ cord-015365-iqdi99pd 1184 9 follow follow NN cord-015365-iqdi99pd 1184 10 - - HYPH cord-015365-iqdi99pd 1184 11 up up NN cord-015365-iqdi99pd 1184 12 for for IN cord-015365-iqdi99pd 1184 13 patients patient NNS cord-015365-iqdi99pd 1184 14 after after IN cord-015365-iqdi99pd 1184 15 heart heart NN cord-015365-iqdi99pd 1184 16 transplantation transplantation NN cord-015365-iqdi99pd 1184 17 , , , cord-015365-iqdi99pd 1184 18 especially especially RB cord-015365-iqdi99pd 1184 19 in in IN cord-015365-iqdi99pd 1184 20 long long JJ cord-015365-iqdi99pd 1184 21 - - HYPH cord-015365-iqdi99pd 1184 22 term term NN cord-015365-iqdi99pd 1184 23 follow follow NN cord-015365-iqdi99pd 1184 24 - - HYPH cord-015365-iqdi99pd 1184 25 up up NN cord-015365-iqdi99pd 1184 26 , , , cord-015365-iqdi99pd 1184 27 as as IN cord-015365-iqdi99pd 1184 28 femoral femoral JJ cord-015365-iqdi99pd 1184 29 approach approach NN cord-015365-iqdi99pd 1184 30 often often RB cord-015365-iqdi99pd 1184 31 leads lead VBZ cord-015365-iqdi99pd 1184 32 to to IN cord-015365-iqdi99pd 1184 33 complications complication NNS cord-015365-iqdi99pd 1184 34 . . . cord-015365-iqdi99pd 1185 1 tation tation NNP cord-015365-iqdi99pd 1185 2 and and CC cord-015365-iqdi99pd 1185 3 repeated repeat VBD cord-015365-iqdi99pd 1185 4 antigen antigen NN cord-015365-iqdi99pd 1185 5 immunoadsorption immunoadsorption NN cord-015365-iqdi99pd 1186 1 ( ( -LRB- cord-015365-iqdi99pd 1186 2 Glycosor Glycosor NNP cord-015365-iqdi99pd 1186 3 - - HYPH cord-015365-iqdi99pd 1186 4 bABO bABO NNP cord-015365-iqdi99pd 1186 5 ) ) -RRB- cord-015365-iqdi99pd 1186 6 until until IN cord-015365-iqdi99pd 1186 7 the the DT cord-015365-iqdi99pd 1186 8 isoagglutinine isoagglutinine NNP cord-015365-iqdi99pd 1186 9 titre titre NNP cord-015365-iqdi99pd 1186 10 was be VBD cord-015365-iqdi99pd 1186 11 less less JJR cord-015365-iqdi99pd 1186 12 than than IN cord-015365-iqdi99pd 1186 13 1:8 1:8 CD cord-015365-iqdi99pd 1186 14 . . . cord-015365-iqdi99pd 1187 1 In in IN cord-015365-iqdi99pd 1187 2 addition addition NN cord-015365-iqdi99pd 1187 3 intravenous intravenous JJ cord-015365-iqdi99pd 1187 4 immunoglobulin immunoglobulin NN cord-015365-iqdi99pd 1187 5 ( ( -LRB- cord-015365-iqdi99pd 1187 6 Intratect Intratect NNP cord-015365-iqdi99pd 1187 7 , , , cord-015365-iqdi99pd 1187 8 Biotest Biotest NNP cord-015365-iqdi99pd 1187 9 Pharma Pharma NNP cord-015365-iqdi99pd 1187 10 ) ) -RRB- cord-015365-iqdi99pd 1187 11 was be VBD cord-015365-iqdi99pd 1187 12 administrated administrate VBN cord-015365-iqdi99pd 1187 13 at at IN cord-015365-iqdi99pd 1187 14 a a DT cord-015365-iqdi99pd 1187 15 dose dose NN cord-015365-iqdi99pd 1187 16 of of IN cord-015365-iqdi99pd 1187 17 1.0 1.0 CD cord-015365-iqdi99pd 1187 18 g g NN cord-015365-iqdi99pd 1187 19 / / SYM cord-015365-iqdi99pd 1187 20 kg kg NN cord-015365-iqdi99pd 1187 21 body body NN cord-015365-iqdi99pd 1187 22 weight weight NN cord-015365-iqdi99pd 1187 23 after after IN cord-015365-iqdi99pd 1187 24 each each DT cord-015365-iqdi99pd 1187 25 immunoadsorption immunoadsorption NN cord-015365-iqdi99pd 1187 26 . . . cord-015365-iqdi99pd 1188 1 A a DT cord-015365-iqdi99pd 1188 2 standard standard JJ cord-015365-iqdi99pd 1188 3 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1188 4 regimen regimen NN cord-015365-iqdi99pd 1188 5 ( ( -LRB- cord-015365-iqdi99pd 1188 6 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1188 7 with with IN cord-015365-iqdi99pd 1188 8 a a DT cord-015365-iqdi99pd 1188 9 target target NN cord-015365-iqdi99pd 1188 10 level level NN cord-015365-iqdi99pd 1188 11 of of IN cord-015365-iqdi99pd 1188 12 10 10 CD cord-015365-iqdi99pd 1188 13 to to TO cord-015365-iqdi99pd 1188 14 12 12 CD cord-015365-iqdi99pd 1188 15 ng ng NN cord-015365-iqdi99pd 1188 16 / / SYM cord-015365-iqdi99pd 1188 17 ml ml NNP cord-015365-iqdi99pd 1188 18 , , , cord-015365-iqdi99pd 1188 19 mycophenolate mycophenolate NNP cord-015365-iqdi99pd 1188 20 mofetil mofetil NNP cord-015365-iqdi99pd 1188 21 at at IN cord-015365-iqdi99pd 1188 22 a a DT cord-015365-iqdi99pd 1188 23 dose dose NN cord-015365-iqdi99pd 1188 24 of of IN cord-015365-iqdi99pd 1188 25 1 1 CD cord-015365-iqdi99pd 1188 26 g g NN cord-015365-iqdi99pd 1188 27 twice twice PDT cord-015365-iqdi99pd 1188 28 a a DT cord-015365-iqdi99pd 1188 29 day day NN cord-015365-iqdi99pd 1188 30 and and CC cord-015365-iqdi99pd 1188 31 prednisolone prednisolone NN cord-015365-iqdi99pd 1188 32 ) ) -RRB- cord-015365-iqdi99pd 1188 33 with with IN cord-015365-iqdi99pd 1188 34 IL-2 IL-2 NNP cord-015365-iqdi99pd 1188 35 antibody antibody NN cord-015365-iqdi99pd 1188 36 induction induction NN cord-015365-iqdi99pd 1188 37 was be VBD cord-015365-iqdi99pd 1188 38 started start VBN cord-015365-iqdi99pd 1188 39 approximately approximately RB cord-015365-iqdi99pd 1188 40 two two CD cord-015365-iqdi99pd 1188 41 weeks week NNS cord-015365-iqdi99pd 1188 42 prior prior RB cord-015365-iqdi99pd 1188 43 to to IN cord-015365-iqdi99pd 1188 44 kidney kidney NN cord-015365-iqdi99pd 1188 45 transplantation transplantation NN cord-015365-iqdi99pd 1188 46 . . . cord-015365-iqdi99pd 1189 1 Results result NNS cord-015365-iqdi99pd 1189 2 . . . cord-015365-iqdi99pd 1190 1 A a DT cord-015365-iqdi99pd 1190 2 total total NN cord-015365-iqdi99pd 1190 3 of of IN cord-015365-iqdi99pd 1190 4 seven seven CD cord-015365-iqdi99pd 1190 5 ABO ABO NNP cord-015365-iqdi99pd 1190 6 incompatible incompatible JJ cord-015365-iqdi99pd 1190 7 kidney kidney NN cord-015365-iqdi99pd 1190 8 transplantations transplantation NNS cord-015365-iqdi99pd 1190 9 were be VBD cord-015365-iqdi99pd 1190 10 performed perform VBN cord-015365-iqdi99pd 1190 11 . . . cord-015365-iqdi99pd 1191 1 Patients patient NNS cord-015365-iqdi99pd 1191 2 ' ' POS cord-015365-iqdi99pd 1191 3 characteristics characteristic NNS cord-015365-iqdi99pd 1191 4 are be VBP cord-015365-iqdi99pd 1191 5 summarised summarise VBN cord-015365-iqdi99pd 1191 6 in in IN cord-015365-iqdi99pd 1191 7 Table Table NNP cord-015365-iqdi99pd 1191 8 1 1 CD cord-015365-iqdi99pd 1191 9 . . . cord-015365-iqdi99pd 1192 1 All all DT cord-015365-iqdi99pd 1192 2 patients patient NNS cord-015365-iqdi99pd 1192 3 showed show VBD cord-015365-iqdi99pd 1192 4 an an DT cord-015365-iqdi99pd 1192 5 immediate immediate JJ cord-015365-iqdi99pd 1192 6 graft graft NN cord-015365-iqdi99pd 1192 7 function function NN cord-015365-iqdi99pd 1192 8 and and CC cord-015365-iqdi99pd 1192 9 their -PRON- PRP$ cord-015365-iqdi99pd 1192 10 serum serum NN cord-015365-iqdi99pd 1192 11 creatinine creatinine NN cord-015365-iqdi99pd 1192 12 decreased decrease VBD cord-015365-iqdi99pd 1192 13 to to IN cord-015365-iqdi99pd 1192 14 a a DT cord-015365-iqdi99pd 1192 15 median median JJ cord-015365-iqdi99pd 1192 16 level level NN cord-015365-iqdi99pd 1192 17 of of IN cord-015365-iqdi99pd 1192 18 1.69 1.69 CD cord-015365-iqdi99pd 1192 19 mg mg NNP cord-015365-iqdi99pd 1192 20 / / SYM cord-015365-iqdi99pd 1192 21 dl dl NNP cord-015365-iqdi99pd 1192 22 ( ( -LRB- cord-015365-iqdi99pd 1192 23 range range NN cord-015365-iqdi99pd 1192 24 : : : cord-015365-iqdi99pd 1192 25 1.09 1.09 CD cord-015365-iqdi99pd 1192 26 - - SYM cord-015365-iqdi99pd 1192 27 3.39 3.39 CD cord-015365-iqdi99pd 1192 28 mg mg NNP cord-015365-iqdi99pd 1192 29 / / SYM cord-015365-iqdi99pd 1192 30 dl dl NNP cord-015365-iqdi99pd 1192 31 ) ) -RRB- cord-015365-iqdi99pd 1192 32 on on IN cord-015365-iqdi99pd 1192 33 day day NN cord-015365-iqdi99pd 1192 34 7 7 CD cord-015365-iqdi99pd 1192 35 . . . cord-015365-iqdi99pd 1193 1 In in IN cord-015365-iqdi99pd 1193 2 one one CD cord-015365-iqdi99pd 1193 3 patient patient NN cord-015365-iqdi99pd 1193 4 there there EX cord-015365-iqdi99pd 1193 5 was be VBD cord-015365-iqdi99pd 1193 6 an an DT cord-015365-iqdi99pd 1193 7 early early JJ cord-015365-iqdi99pd 1193 8 loss loss NN cord-015365-iqdi99pd 1193 9 of of IN cord-015365-iqdi99pd 1193 10 graft graft NN cord-015365-iqdi99pd 1193 11 function function NN cord-015365-iqdi99pd 1193 12 due due IN cord-015365-iqdi99pd 1193 13 to to IN cord-015365-iqdi99pd 1193 14 thrombotic thrombotic JJ cord-015365-iqdi99pd 1193 15 microangiopathy microangiopathy NNP cord-015365-iqdi99pd 1193 16 despite despite IN cord-015365-iqdi99pd 1193 17 rescue rescue NN cord-015365-iqdi99pd 1193 18 treatment treatment NN cord-015365-iqdi99pd 1193 19 with with IN cord-015365-iqdi99pd 1193 20 bortezomib bortezomib NNP cord-015365-iqdi99pd 1193 21 and and CC cord-015365-iqdi99pd 1193 22 eculizumab eculizumab NNS cord-015365-iqdi99pd 1193 23 leading lead VBG cord-015365-iqdi99pd 1193 24 to to IN cord-015365-iqdi99pd 1193 25 graft graft NN cord-015365-iqdi99pd 1193 26 loss loss NN cord-015365-iqdi99pd 1193 27 on on IN cord-015365-iqdi99pd 1193 28 day day NN cord-015365-iqdi99pd 1193 29 21 21 CD cord-015365-iqdi99pd 1193 30 . . . cord-015365-iqdi99pd 1194 1 After after IN cord-015365-iqdi99pd 1194 2 a a DT cord-015365-iqdi99pd 1194 3 median median NN cord-015365-iqdi99pd 1194 4 follow follow NN cord-015365-iqdi99pd 1194 5 up up IN cord-015365-iqdi99pd 1194 6 of of IN cord-015365-iqdi99pd 1194 7 3.7 3.7 CD cord-015365-iqdi99pd 1194 8 months month NNS cord-015365-iqdi99pd 1194 9 , , , cord-015365-iqdi99pd 1194 10 serum serum NN cord-015365-iqdi99pd 1194 11 creatinine creatinine NN cord-015365-iqdi99pd 1194 12 averaged average VBD cord-015365-iqdi99pd 1194 13 1.7 1.7 CD cord-015365-iqdi99pd 1194 14 mg mg NNP cord-015365-iqdi99pd 1194 15 / / SYM cord-015365-iqdi99pd 1194 16 dl dl NNP cord-015365-iqdi99pd 1194 17 ( ( -LRB- cord-015365-iqdi99pd 1194 18 range range NN cord-015365-iqdi99pd 1194 19 : : : cord-015365-iqdi99pd 1194 20 1.25 1.25 CD cord-015365-iqdi99pd 1194 21 - - SYM cord-015365-iqdi99pd 1194 22 2.27 2.27 CD cord-015365-iqdi99pd 1194 23 mg mg NNP cord-015365-iqdi99pd 1194 24 / / SYM cord-015365-iqdi99pd 1194 25 dl dl NNP cord-015365-iqdi99pd 1194 26 ) ) -RRB- cord-015365-iqdi99pd 1194 27 . . . cord-015365-iqdi99pd 1195 1 In in IN cord-015365-iqdi99pd 1195 2 the the DT cord-015365-iqdi99pd 1195 3 performed perform VBN cord-015365-iqdi99pd 1195 4 renal renal JJ cord-015365-iqdi99pd 1195 5 biopsies biopsy NNS cord-015365-iqdi99pd 1195 6 there there EX cord-015365-iqdi99pd 1195 7 was be VBD cord-015365-iqdi99pd 1195 8 no no DT cord-015365-iqdi99pd 1195 9 evidence evidence NN cord-015365-iqdi99pd 1195 10 of of IN cord-015365-iqdi99pd 1195 11 relevant relevant JJ cord-015365-iqdi99pd 1195 12 acute acute JJ cord-015365-iqdi99pd 1195 13 or or CC cord-015365-iqdi99pd 1195 14 chronic chronic JJ cord-015365-iqdi99pd 1195 15 graft graft NN cord-015365-iqdi99pd 1195 16 injury injury NN cord-015365-iqdi99pd 1195 17 , , , cord-015365-iqdi99pd 1195 18 all all DT cord-015365-iqdi99pd 1195 19 allografts allograft NNS cord-015365-iqdi99pd 1195 20 showed show VBD cord-015365-iqdi99pd 1195 21 C4d C4d NNP cord-015365-iqdi99pd 1195 22 positive positive JJ cord-015365-iqdi99pd 1195 23 immunostaining immunostaining NN cord-015365-iqdi99pd 1195 24 . . . cord-015365-iqdi99pd 1196 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1196 2 . . . cord-015365-iqdi99pd 1197 1 In in IN cord-015365-iqdi99pd 1197 2 conclusion conclusion NN cord-015365-iqdi99pd 1197 3 , , , cord-015365-iqdi99pd 1197 4 our -PRON- PRP$ cord-015365-iqdi99pd 1197 5 small small JJ cord-015365-iqdi99pd 1197 6 case case NN cord-015365-iqdi99pd 1197 7 series series NN cord-015365-iqdi99pd 1197 8 demonstrated demonstrate VBD cord-015365-iqdi99pd 1197 9 that that IN cord-015365-iqdi99pd 1197 10 perioperative perioperative JJ cord-015365-iqdi99pd 1197 11 isoagglutinine isoagglutinine JJ cord-015365-iqdi99pd 1197 12 removal removal NN cord-015365-iqdi99pd 1197 13 in in IN cord-015365-iqdi99pd 1197 14 combination combination NN cord-015365-iqdi99pd 1197 15 with with IN cord-015365-iqdi99pd 1197 16 rituximab rituximab NN cord-015365-iqdi99pd 1197 17 is be VBZ cord-015365-iqdi99pd 1197 18 an an DT cord-015365-iqdi99pd 1197 19 effective effective JJ cord-015365-iqdi99pd 1197 20 and and CC cord-015365-iqdi99pd 1197 21 safe safe JJ cord-015365-iqdi99pd 1197 22 protocol protocol NN cord-015365-iqdi99pd 1197 23 for for IN cord-015365-iqdi99pd 1197 24 ABO ABO NNP cord-015365-iqdi99pd 1197 25 incompatible incompatible JJ cord-015365-iqdi99pd 1197 26 transplantation transplantation NN cord-015365-iqdi99pd 1197 27 . . . cord-015365-iqdi99pd 1198 1 Therefore therefore RB cord-015365-iqdi99pd 1198 2 we -PRON- PRP cord-015365-iqdi99pd 1198 3 offer offer VBP cord-015365-iqdi99pd 1198 4 ABO ABO NNP cord-015365-iqdi99pd 1198 5 incompatible incompatible JJ cord-015365-iqdi99pd 1198 6 kidney kidney NN cord-015365-iqdi99pd 1198 7 transplantation transplantation NN cord-015365-iqdi99pd 1198 8 to to IN cord-015365-iqdi99pd 1198 9 patients patient NNS cord-015365-iqdi99pd 1198 10 as as IN cord-015365-iqdi99pd 1198 11 alternative alternative JJ cord-015365-iqdi99pd 1198 12 to to IN cord-015365-iqdi99pd 1198 13 cadaveric cadaveric JJ cord-015365-iqdi99pd 1198 14 kidney kidney NN cord-015365-iqdi99pd 1198 15 transplantation transplantation NN cord-015365-iqdi99pd 1198 16 to to TO cord-015365-iqdi99pd 1198 17 shorten shorten VB cord-015365-iqdi99pd 1198 18 the the DT cord-015365-iqdi99pd 1198 19 waiting wait VBG cord-015365-iqdi99pd 1198 20 time time NN cord-015365-iqdi99pd 1198 21 on on IN cord-015365-iqdi99pd 1198 22 dialysis dialysis NN cord-015365-iqdi99pd 1198 23 . . . cord-015365-iqdi99pd 1199 1 Background background NN cord-015365-iqdi99pd 1199 2 . . . cord-015365-iqdi99pd 1200 1 Amyloidosis Amyloidosis NNP cord-015365-iqdi99pd 1200 2 is be VBZ cord-015365-iqdi99pd 1200 3 a a DT cord-015365-iqdi99pd 1200 4 protein protein NN cord-015365-iqdi99pd 1200 5 misfolding misfolde VBG cord-015365-iqdi99pd 1200 6 disorder disorder NN cord-015365-iqdi99pd 1200 7 where where WRB cord-015365-iqdi99pd 1200 8 conformationally conformationally RB cord-015365-iqdi99pd 1200 9 changed change VBN cord-015365-iqdi99pd 1200 10 proteins protein NNS cord-015365-iqdi99pd 1200 11 are be VBP cord-015365-iqdi99pd 1200 12 pathologically pathologically RB cord-015365-iqdi99pd 1200 13 deposited deposit VBN cord-015365-iqdi99pd 1200 14 as as IN cord-015365-iqdi99pd 1200 15 abnormal abnormal JJ cord-015365-iqdi99pd 1200 16 insoluble insoluble JJ cord-015365-iqdi99pd 1200 17 fibrils fibril NNS cord-015365-iqdi99pd 1200 18 in in IN cord-015365-iqdi99pd 1200 19 distinct distinct JJ cord-015365-iqdi99pd 1200 20 tissues tissue NNS cord-015365-iqdi99pd 1200 21 potentially potentially RB cord-015365-iqdi99pd 1200 22 leading lead VBG cord-015365-iqdi99pd 1200 23 to to IN cord-015365-iqdi99pd 1200 24 morphological morphological JJ cord-015365-iqdi99pd 1200 25 and and CC cord-015365-iqdi99pd 1200 26 functional functional JJ cord-015365-iqdi99pd 1200 27 disintegration disintegration NN cord-015365-iqdi99pd 1200 28 . . . cord-015365-iqdi99pd 1201 1 Heredi Heredi NNP cord-015365-iqdi99pd 1201 2 - - HYPH cord-015365-iqdi99pd 1201 3 tary tary NNP cord-015365-iqdi99pd 1201 4 amyloidosis amyloidosis NN cord-015365-iqdi99pd 1201 5 is be VBZ cord-015365-iqdi99pd 1201 6 a a DT cord-015365-iqdi99pd 1201 7 rare rare JJ cord-015365-iqdi99pd 1201 8 autosomal autosomal JJ cord-015365-iqdi99pd 1201 9 - - HYPH cord-015365-iqdi99pd 1201 10 dominant dominant JJ cord-015365-iqdi99pd 1201 11 disorder disorder NN cord-015365-iqdi99pd 1201 12 arising arise VBG cord-015365-iqdi99pd 1201 13 from from IN cord-015365-iqdi99pd 1201 14 mutations mutation NNS cord-015365-iqdi99pd 1201 15 in in IN cord-015365-iqdi99pd 1201 16 several several JJ cord-015365-iqdi99pd 1201 17 genes gene NNS cord-015365-iqdi99pd 1201 18 like like IN cord-015365-iqdi99pd 1201 19 in in IN cord-015365-iqdi99pd 1201 20 the the DT cord-015365-iqdi99pd 1201 21 fibrinogen fibrinogen NN cord-015365-iqdi99pd 1201 22 A a NN cord-015365-iqdi99pd 1201 23 - - HYPH cord-015365-iqdi99pd 1201 24 chain chain NN cord-015365-iqdi99pd 1201 25 that that WDT cord-015365-iqdi99pd 1201 26 affect affect VBP cord-015365-iqdi99pd 1201 27 various various JJ cord-015365-iqdi99pd 1201 28 organs organ NNS cord-015365-iqdi99pd 1201 29 . . . cord-015365-iqdi99pd 1202 1 Mutations mutation NNS cord-015365-iqdi99pd 1202 2 in in IN cord-015365-iqdi99pd 1202 3 the the DT cord-015365-iqdi99pd 1202 4 fibrinogen fibrinogen NN cord-015365-iqdi99pd 1202 5 A a NN cord-015365-iqdi99pd 1202 6 - - HYPH cord-015365-iqdi99pd 1202 7 chain chain NN cord-015365-iqdi99pd 1202 8 have have VBP cord-015365-iqdi99pd 1202 9 been be VBN cord-015365-iqdi99pd 1202 10 discussed discuss VBN cord-015365-iqdi99pd 1202 11 to to TO cord-015365-iqdi99pd 1202 12 lead lead VB cord-015365-iqdi99pd 1202 13 to to IN cord-015365-iqdi99pd 1202 14 a a DT cord-015365-iqdi99pd 1202 15 predominant predominant JJ cord-015365-iqdi99pd 1202 16 renal renal JJ cord-015365-iqdi99pd 1202 17 deposition deposition NN cord-015365-iqdi99pd 1202 18 of of IN cord-015365-iqdi99pd 1202 19 amyloid amyloid NN cord-015365-iqdi99pd 1202 20 generally generally RB cord-015365-iqdi99pd 1202 21 leading lead VBG cord-015365-iqdi99pd 1202 22 to to IN cord-015365-iqdi99pd 1202 23 ESRD ESRD NNP cord-015365-iqdi99pd 1202 24 . . . cord-015365-iqdi99pd 1203 1 Methods method NNS cord-015365-iqdi99pd 1203 2 . . . cord-015365-iqdi99pd 1204 1 Here here RB cord-015365-iqdi99pd 1204 2 , , , cord-015365-iqdi99pd 1204 3 we -PRON- PRP cord-015365-iqdi99pd 1204 4 describe describe VBP cord-015365-iqdi99pd 1204 5 a a DT cord-015365-iqdi99pd 1204 6 large large JJ cord-015365-iqdi99pd 1204 7 Spanish spanish JJ cord-015365-iqdi99pd 1204 8 family family NN cord-015365-iqdi99pd 1204 9 with with IN cord-015365-iqdi99pd 1204 10 101 101 CD cord-015365-iqdi99pd 1204 11 members member NNS cord-015365-iqdi99pd 1204 12 affected affect VBN cord-015365-iqdi99pd 1204 13 by by IN cord-015365-iqdi99pd 1204 14 the the DT cord-015365-iqdi99pd 1204 15 rare rare JJ cord-015365-iqdi99pd 1204 16 fibrinogen fibrinogen NN cord-015365-iqdi99pd 1204 17 R554L r554l NN cord-015365-iqdi99pd 1204 18 mutation mutation NN cord-015365-iqdi99pd 1204 19 and and CC cord-015365-iqdi99pd 1204 20 isolated isolate VBN cord-015365-iqdi99pd 1204 21 renal renal JJ cord-015365-iqdi99pd 1204 22 amyloidosis amyloidosis NN cord-015365-iqdi99pd 1204 23 . . . cord-015365-iqdi99pd 1205 1 Results result NNS cord-015365-iqdi99pd 1205 2 . . . cord-015365-iqdi99pd 1206 1 Most Most JJS cord-015365-iqdi99pd 1206 2 patients patient NNS cord-015365-iqdi99pd 1206 3 presented present VBN cord-015365-iqdi99pd 1206 4 with with IN cord-015365-iqdi99pd 1206 5 late late JJ cord-015365-iqdi99pd 1206 6 - - HYPH cord-015365-iqdi99pd 1206 7 onset onset NN cord-015365-iqdi99pd 1206 8 gross gross JJ cord-015365-iqdi99pd 1206 9 proteinuria proteinuria NN cord-015365-iqdi99pd 1206 10 and and CC cord-015365-iqdi99pd 1206 11 a a DT cord-015365-iqdi99pd 1206 12 variable variable JJ cord-015365-iqdi99pd 1206 13 course course NN cord-015365-iqdi99pd 1206 14 of of IN cord-015365-iqdi99pd 1206 15 decline decline NN cord-015365-iqdi99pd 1206 16 of of IN cord-015365-iqdi99pd 1206 17 renal renal JJ cord-015365-iqdi99pd 1206 18 function function NN cord-015365-iqdi99pd 1206 19 . . . cord-015365-iqdi99pd 1207 1 In in IN cord-015365-iqdi99pd 1207 2 contrast contrast NN cord-015365-iqdi99pd 1207 3 to to IN cord-015365-iqdi99pd 1207 4 other other JJ cord-015365-iqdi99pd 1207 5 reported report VBN cord-015365-iqdi99pd 1207 6 fibrinogen fibrinogen NN cord-015365-iqdi99pd 1207 7 A A NNP cord-015365-iqdi99pd 1207 8 mutations mutation NNS cord-015365-iqdi99pd 1207 9 , , , cord-015365-iqdi99pd 1207 10 extrarenal extrarenal JJ cord-015365-iqdi99pd 1207 11 involvement involvement NN cord-015365-iqdi99pd 1207 12 or or CC cord-015365-iqdi99pd 1207 13 accelerated accelerated JJ cord-015365-iqdi99pd 1207 14 arteriosclerosis arteriosclerosis NN cord-015365-iqdi99pd 1207 15 employing employ VBG cord-015365-iqdi99pd 1207 16 cardiac cardiac JJ cord-015365-iqdi99pd 1207 17 magnetic magnetic JJ cord-015365-iqdi99pd 1207 18 resonance resonance NN cord-015365-iqdi99pd 1207 19 imaging imaging NN cord-015365-iqdi99pd 1207 20 , , , cord-015365-iqdi99pd 1207 21 carotid carotid JJ cord-015365-iqdi99pd 1207 22 ultrasound ultrasound NN cord-015365-iqdi99pd 1207 23 and and CC cord-015365-iqdi99pd 1207 24 tissue tissue NN cord-015365-iqdi99pd 1207 25 biopsy biopsy NN cord-015365-iqdi99pd 1207 26 was be VBD cord-015365-iqdi99pd 1207 27 not not RB cord-015365-iqdi99pd 1207 28 observed observe VBN cord-015365-iqdi99pd 1207 29 indicating indicate VBG cord-015365-iqdi99pd 1207 30 a a DT cord-015365-iqdi99pd 1207 31 highly highly RB cord-015365-iqdi99pd 1207 32 selective selective JJ cord-015365-iqdi99pd 1207 33 process process NN cord-015365-iqdi99pd 1207 34 of of IN cord-015365-iqdi99pd 1207 35 renal renal JJ cord-015365-iqdi99pd 1207 36 amyloid amyloid NN cord-015365-iqdi99pd 1207 37 deposition deposition NN cord-015365-iqdi99pd 1207 38 . . . cord-015365-iqdi99pd 1208 1 Histological Histological NNP cord-015365-iqdi99pd 1208 2 analysis analysis NN cord-015365-iqdi99pd 1208 3 revealed reveal VBD cord-015365-iqdi99pd 1208 4 almost almost RB cord-015365-iqdi99pd 1208 5 complete complete JJ cord-015365-iqdi99pd 1208 6 obliteration obliteration NN cord-015365-iqdi99pd 1208 7 of of IN cord-015365-iqdi99pd 1208 8 the the DT cord-015365-iqdi99pd 1208 9 glomerular glomerular JJ cord-015365-iqdi99pd 1208 10 and and CC cord-015365-iqdi99pd 1208 11 specifically specifically RB cord-015365-iqdi99pd 1208 12 the the DT cord-015365-iqdi99pd 1208 13 mesangial mesangial JJ cord-015365-iqdi99pd 1208 14 architecture architecture NN cord-015365-iqdi99pd 1208 15 despite despite IN cord-015365-iqdi99pd 1208 16 moderately moderately RB cord-015365-iqdi99pd 1208 17 reduced reduce VBN cord-015365-iqdi99pd 1208 18 kidney kidney NN cord-015365-iqdi99pd 1208 19 function function NN cord-015365-iqdi99pd 1208 20 . . . cord-015365-iqdi99pd 1209 1 Treatment treatment NN cord-015365-iqdi99pd 1209 2 with with IN cord-015365-iqdi99pd 1209 3 angiotensin angiotensin NN cord-015365-iqdi99pd 1209 4 - - HYPH cord-015365-iqdi99pd 1209 5 converting convert VBG cord-015365-iqdi99pd 1209 6 enzyme enzyme NN cord-015365-iqdi99pd 1209 7 and and CC cord-015365-iqdi99pd 1210 1 subsequently subsequently RB cord-015365-iqdi99pd 1210 2 angiotensin angiotensin NN cord-015365-iqdi99pd 1210 3 - - HYPH cord-015365-iqdi99pd 1210 4 II II NNP cord-015365-iqdi99pd 1210 5 receptor receptor NN cord-015365-iqdi99pd 1210 6 inhibitors inhibitor NNS cord-015365-iqdi99pd 1210 7 did do VBD cord-015365-iqdi99pd 1210 8 not not RB cord-015365-iqdi99pd 1210 9 significantly significantly RB cord-015365-iqdi99pd 1210 10 affect affect VB cord-015365-iqdi99pd 1210 11 proteinuria proteinuria NN cord-015365-iqdi99pd 1210 12 . . . cord-015365-iqdi99pd 1211 1 Two two CD cord-015365-iqdi99pd 1211 2 affected affected JJ cord-015365-iqdi99pd 1211 3 members member NNS cord-015365-iqdi99pd 1211 4 underwent undergo VBD cord-015365-iqdi99pd 1211 5 renal renal JJ cord-015365-iqdi99pd 1211 6 transplantation transplantation NN cord-015365-iqdi99pd 1211 7 with with IN cord-015365-iqdi99pd 1211 8 the the DT cord-015365-iqdi99pd 1211 9 longest long JJS cord-015365-iqdi99pd 1211 10 surviving survive VBG cord-015365-iqdi99pd 1211 11 graft graft NN cord-015365-iqdi99pd 1211 12 exhibiting exhibit VBG cord-015365-iqdi99pd 1211 13 13 13 CD cord-015365-iqdi99pd 1211 14 years year NNS cord-015365-iqdi99pd 1211 15 of of IN cord-015365-iqdi99pd 1211 16 survival survival NN cord-015365-iqdi99pd 1211 17 and and CC cord-015365-iqdi99pd 1211 18 graft graft NN cord-015365-iqdi99pd 1211 19 failure failure NN cord-015365-iqdi99pd 1211 20 due due JJ cord-015365-iqdi99pd 1211 21 to to IN cord-015365-iqdi99pd 1211 22 surgical surgical JJ cord-015365-iqdi99pd 1211 23 and and CC cord-015365-iqdi99pd 1211 24 infectious infectious JJ cord-015365-iqdi99pd 1211 25 problems problem NNS cord-015365-iqdi99pd 1211 26 , , , cord-015365-iqdi99pd 1211 27 but but CC cord-015365-iqdi99pd 1211 28 recurrence recurrence NN cord-015365-iqdi99pd 1211 29 of of IN cord-015365-iqdi99pd 1211 30 amyloidosis amyloidosis NN cord-015365-iqdi99pd 1211 31 . . . cord-015365-iqdi99pd 1212 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1212 2 . . . cord-015365-iqdi99pd 1213 1 Collectively collectively RB cord-015365-iqdi99pd 1213 2 , , , cord-015365-iqdi99pd 1213 3 these these DT cord-015365-iqdi99pd 1213 4 results result NNS cord-015365-iqdi99pd 1213 5 introduce introduce VBP cord-015365-iqdi99pd 1213 6 a a DT cord-015365-iqdi99pd 1213 7 new new JJ cord-015365-iqdi99pd 1213 8 perspective perspective NN cord-015365-iqdi99pd 1213 9 on on IN cord-015365-iqdi99pd 1213 10 this this DT cord-015365-iqdi99pd 1213 11 atypical atypical JJ cord-015365-iqdi99pd 1213 12 fibrinogen fibrinogen NN cord-015365-iqdi99pd 1213 13 mutation mutation NN cord-015365-iqdi99pd 1213 14 with with IN cord-015365-iqdi99pd 1213 15 significant significant JJ cord-015365-iqdi99pd 1213 16 pathophysiological pathophysiological JJ cord-015365-iqdi99pd 1213 17 and and CC cord-015365-iqdi99pd 1213 18 clinical clinical JJ cord-015365-iqdi99pd 1213 19 impact impact NN cord-015365-iqdi99pd 1213 20 also also RB cord-015365-iqdi99pd 1213 21 with with IN cord-015365-iqdi99pd 1213 22 regard regard NN cord-015365-iqdi99pd 1213 23 to to IN cord-015365-iqdi99pd 1213 24 novel novel JJ cord-015365-iqdi99pd 1213 25 therapeutical therapeutical JJ cord-015365-iqdi99pd 1213 26 approaches approach NNS cord-015365-iqdi99pd 1213 27 . . . cord-015365-iqdi99pd 1214 1 Methods method NNS cord-015365-iqdi99pd 1214 2 . . . cord-015365-iqdi99pd 1215 1 217 217 CD cord-015365-iqdi99pd 1215 2 enteric enteric NN cord-015365-iqdi99pd 1215 3 drained drain VBN cord-015365-iqdi99pd 1215 4 whole whole JJ cord-015365-iqdi99pd 1215 5 pancreas pancreas NN cord-015365-iqdi99pd 1215 6 transplants transplant NNS cord-015365-iqdi99pd 1215 7 ( ( -LRB- cord-015365-iqdi99pd 1215 8 PTx PTx NNS cord-015365-iqdi99pd 1215 9 ) ) -RRB- cord-015365-iqdi99pd 1215 10 in in IN cord-015365-iqdi99pd 1215 11 208 208 CD cord-015365-iqdi99pd 1215 12 patients patient NNS cord-015365-iqdi99pd 1215 13 performed perform VBN cord-015365-iqdi99pd 1215 14 at at IN cord-015365-iqdi99pd 1215 15 our -PRON- PRP$ cord-015365-iqdi99pd 1215 16 center center NN cord-015365-iqdi99pd 1215 17 during during IN cord-015365-iqdi99pd 1215 18 a a DT cord-015365-iqdi99pd 1215 19 seven seven CD cord-015365-iqdi99pd 1215 20 year year NN cord-015365-iqdi99pd 1215 21 period period NN cord-015365-iqdi99pd 1215 22 were be VBD cord-015365-iqdi99pd 1215 23 retrospectively retrospectively RB cord-015365-iqdi99pd 1215 24 analysed analyse VBN cord-015365-iqdi99pd 1215 25 . . . cord-015365-iqdi99pd 1216 1 Prophylactic prophylactic JJ cord-015365-iqdi99pd 1216 2 immunosup- immunosup- NN cord-015365-iqdi99pd 1216 3 Type type NN cord-015365-iqdi99pd 1216 4 II II NNP cord-015365-iqdi99pd 1216 5 DM DM NNP cord-015365-iqdi99pd 1216 6 was be VBD cord-015365-iqdi99pd 1216 7 defined define VBN cord-015365-iqdi99pd 1216 8 as as IN cord-015365-iqdi99pd 1216 9 requirement requirement NN cord-015365-iqdi99pd 1216 10 of of IN cord-015365-iqdi99pd 1216 11 insulin insulin NN cord-015365-iqdi99pd 1216 12 or or CC cord-015365-iqdi99pd 1216 13 oral oral JJ cord-015365-iqdi99pd 1216 14 antidiabetics antidiabetic NNS cord-015365-iqdi99pd 1216 15 in in IN cord-015365-iqdi99pd 1216 16 the the DT cord-015365-iqdi99pd 1216 17 presence presence NN cord-015365-iqdi99pd 1216 18 of of IN cord-015365-iqdi99pd 1216 19 C c NN cord-015365-iqdi99pd 1216 20 - - HYPH cord-015365-iqdi99pd 1216 21 peptide peptide NN cord-015365-iqdi99pd 1216 22 production production NN cord-015365-iqdi99pd 1216 23 to to TO cord-015365-iqdi99pd 1216 24 maintain maintain VB cord-015365-iqdi99pd 1216 25 blood blood NN cord-015365-iqdi99pd 1216 26 glucose glucose NN cord-015365-iqdi99pd 1216 27 levels level NNS cord-015365-iqdi99pd 1216 28 < < XX cord-015365-iqdi99pd 1216 29 200 200 CD cord-015365-iqdi99pd 1217 1 mg mg NNP cord-015365-iqdi99pd 1217 2 / / SYM cord-015365-iqdi99pd 1217 3 dl dl NN cord-015365-iqdi99pd 1217 4 . . . cord-015365-iqdi99pd 1217 5 Results result NNS cord-015365-iqdi99pd 1217 6 . . . cord-015365-iqdi99pd 1218 1 Actuarial actuarial JJ cord-015365-iqdi99pd 1218 2 patient patient NN cord-015365-iqdi99pd 1218 3 , , , cord-015365-iqdi99pd 1218 4 pancreas pancreas NN cord-015365-iqdi99pd 1218 5 and and CC cord-015365-iqdi99pd 1218 6 kidney kidney NN cord-015365-iqdi99pd 1218 7 graft graft NN cord-015365-iqdi99pd 1218 8 survival survival NN cord-015365-iqdi99pd 1218 9 at at IN cord-015365-iqdi99pd 1218 10 one one CD cord-015365-iqdi99pd 1218 11 year year NN cord-015365-iqdi99pd 1218 12 were be VBD cord-015365-iqdi99pd 1218 13 96.4 96.4 CD cord-015365-iqdi99pd 1218 14 % % NN cord-015365-iqdi99pd 1218 15 , , , cord-015365-iqdi99pd 1218 16 88.5 88.5 CD cord-015365-iqdi99pd 1218 17 % % NN cord-015365-iqdi99pd 1218 18 and and CC cord-015365-iqdi99pd 1218 19 94.8 94.8 CD cord-015365-iqdi99pd 1218 20 % % NN cord-015365-iqdi99pd 1218 21 . . . cord-015365-iqdi99pd 1219 1 At at IN cord-015365-iqdi99pd 1219 2 last last JJ cord-015365-iqdi99pd 1219 3 follow follow NN cord-015365-iqdi99pd 1219 4 up up RP cord-015365-iqdi99pd 1219 5 , , , cord-015365-iqdi99pd 1219 6 two two CD cord-015365-iqdi99pd 1219 7 patients patient NNS cord-015365-iqdi99pd 1219 8 were be VBD cord-015365-iqdi99pd 1219 9 lost lose VBN cord-015365-iqdi99pd 1219 10 , , , cord-015365-iqdi99pd 1219 11 30 30 CD cord-015365-iqdi99pd 1219 12 patients patient NNS cord-015365-iqdi99pd 1219 13 died die VBD cord-015365-iqdi99pd 1219 14 , , , cord-015365-iqdi99pd 1219 15 26 26 CD cord-015365-iqdi99pd 1219 16 pancreatic pancreatic JJ cord-015365-iqdi99pd 1219 17 grafts graft NNS cord-015365-iqdi99pd 1219 18 and and CC cord-015365-iqdi99pd 1219 19 16 16 CD cord-015365-iqdi99pd 1219 20 renal renal JJ cord-015365-iqdi99pd 1219 21 allografts allograft NNS cord-015365-iqdi99pd 1219 22 were be VBD cord-015365-iqdi99pd 1219 23 lost lose VBN cord-015365-iqdi99pd 1219 24 . . . cord-015365-iqdi99pd 1220 1 A a DT cord-015365-iqdi99pd 1220 2 total total NN cord-015365-iqdi99pd 1220 3 of of IN cord-015365-iqdi99pd 1220 4 17 17 CD cord-015365-iqdi99pd 1220 5 patients patient NNS cord-015365-iqdi99pd 1220 6 were be VBD cord-015365-iqdi99pd 1220 7 C c NN cord-015365-iqdi99pd 1220 8 - - HYPH cord-015365-iqdi99pd 1220 9 peptide peptide NN cord-015365-iqdi99pd 1220 10 positive positive JJ cord-015365-iqdi99pd 1220 11 at at IN cord-015365-iqdi99pd 1220 12 the the DT cord-015365-iqdi99pd 1220 13 time time NN cord-015365-iqdi99pd 1220 14 of of IN cord-015365-iqdi99pd 1220 15 PTx PTx NNS cord-015365-iqdi99pd 1220 16 ; ; : cord-015365-iqdi99pd 1220 17 three three CD cord-015365-iqdi99pd 1220 18 patients patient NNS cord-015365-iqdi99pd 1220 19 were be VBD cord-015365-iqdi99pd 1220 20 excluded exclude VBN cord-015365-iqdi99pd 1220 21 from from IN cord-015365-iqdi99pd 1220 22 analysis analysis NN cord-015365-iqdi99pd 1220 23 due due IN cord-015365-iqdi99pd 1220 24 to to IN cord-015365-iqdi99pd 1220 25 early early JJ cord-015365-iqdi99pd 1220 26 graft graft NN cord-015365-iqdi99pd 1220 27 loss loss NN cord-015365-iqdi99pd 1220 28 ( ( -LRB- cord-015365-iqdi99pd 1220 29 n n NN cord-015365-iqdi99pd 1220 30 ¼ ¼ NNP cord-015365-iqdi99pd 1220 31 2 2 CD cord-015365-iqdi99pd 1220 32 ) ) -RRB- cord-015365-iqdi99pd 1220 33 and and CC cord-015365-iqdi99pd 1220 34 DM DM NNP cord-015365-iqdi99pd 1220 35 type type NN cord-015365-iqdi99pd 1220 36 II II NNP cord-015365-iqdi99pd 1220 37 due due JJ cord-015365-iqdi99pd 1220 38 to to IN cord-015365-iqdi99pd 1220 39 partial partial JJ cord-015365-iqdi99pd 1220 40 insufficiency insufficiency NN cord-015365-iqdi99pd 1220 41 of of IN cord-015365-iqdi99pd 1220 42 a a DT cord-015365-iqdi99pd 1220 43 previous previous JJ cord-015365-iqdi99pd 1220 44 pancreatic pancreatic NN cord-015365-iqdi99pd 1220 45 allograft allograft NN cord-015365-iqdi99pd 1220 46 ( ( -LRB- cord-015365-iqdi99pd 1220 47 n n NN cord-015365-iqdi99pd 1220 48 ¼ ¼ NNP cord-015365-iqdi99pd 1220 49 1 1 CD cord-015365-iqdi99pd 1220 50 ) ) -RRB- cord-015365-iqdi99pd 1220 51 . . . cord-015365-iqdi99pd 1221 1 Of of IN cord-015365-iqdi99pd 1221 2 the the DT cord-015365-iqdi99pd 1221 3 14 14 CD cord-015365-iqdi99pd 1221 4 study study NN cord-015365-iqdi99pd 1221 5 patients patient NNS cord-015365-iqdi99pd 1221 6 ( ( -LRB- cord-015365-iqdi99pd 1221 7 13 13 CD cord-015365-iqdi99pd 1221 8 men/1 men/1 NN cord-015365-iqdi99pd 1221 9 woman woman NN cord-015365-iqdi99pd 1221 10 with with IN cord-015365-iqdi99pd 1221 11 a a DT cord-015365-iqdi99pd 1221 12 median median JJ cord-015365-iqdi99pd 1221 13 age age NN cord-015365-iqdi99pd 1221 14 of of IN cord-015365-iqdi99pd 1221 15 56 56 CD cord-015365-iqdi99pd 1221 16 [ [ -LRB- cord-015365-iqdi99pd 1221 17 range range NN cord-015365-iqdi99pd 1221 18 41 41 CD cord-015365-iqdi99pd 1221 19 - - SYM cord-015365-iqdi99pd 1221 20 62 62 CD cord-015365-iqdi99pd 1221 21 ] ] -RRB- cord-015365-iqdi99pd 1221 22 years year NNS cord-015365-iqdi99pd 1221 23 , , , cord-015365-iqdi99pd 1221 24 two two CD cord-015365-iqdi99pd 1221 25 died die VBD cord-015365-iqdi99pd 1221 26 [ [ -LRB- cord-015365-iqdi99pd 1221 27 invasive invasive JJ cord-015365-iqdi99pd 1221 28 fungal fungal JJ cord-015365-iqdi99pd 1221 29 infection infection NN cord-015365-iqdi99pd 1221 30 1 1 CD cord-015365-iqdi99pd 1221 31 , , , cord-015365-iqdi99pd 1221 32 intracerebral intracerebral JJ cord-015365-iqdi99pd 1221 33 bleeding bleed VBG cord-015365-iqdi99pd 1221 34 1 1 CD cord-015365-iqdi99pd 1221 35 ] ] -RRB- cord-015365-iqdi99pd 1221 36 ) ) -RRB- cord-015365-iqdi99pd 1221 37 , , , cord-015365-iqdi99pd 1221 38 another another DT cord-015365-iqdi99pd 1221 39 two two CD cord-015365-iqdi99pd 1221 40 lost lose VBD cord-015365-iqdi99pd 1221 41 their -PRON- PRP$ cord-015365-iqdi99pd 1221 42 pancreatic pancreatic JJ cord-015365-iqdi99pd 1221 43 graft graft NN cord-015365-iqdi99pd 1221 44 [ [ -LRB- cord-015365-iqdi99pd 1221 45 hyperacute hyperacute NN cord-015365-iqdi99pd 1221 46 rejection rejection NN cord-015365-iqdi99pd 1221 47 1 1 CD cord-015365-iqdi99pd 1221 48 , , , cord-015365-iqdi99pd 1221 49 chronic chronic JJ cord-015365-iqdi99pd 1221 50 rejection rejection NN cord-015365-iqdi99pd 1221 51 1 1 CD cord-015365-iqdi99pd 1221 52 ] ] -RRB- cord-015365-iqdi99pd 1221 53 ) ) -RRB- cord-015365-iqdi99pd 1222 1 but but CC cord-015365-iqdi99pd 1222 2 none none NN cord-015365-iqdi99pd 1222 3 their -PRON- PRP$ cord-015365-iqdi99pd 1222 4 renal renal JJ cord-015365-iqdi99pd 1222 5 graft graft NN cord-015365-iqdi99pd 1222 6 . . . cord-015365-iqdi99pd 1223 1 Rejection rejection NN cord-015365-iqdi99pd 1223 2 rate rate NN cord-015365-iqdi99pd 1223 3 was be VBD cord-015365-iqdi99pd 1223 4 28.6 28.6 CD cord-015365-iqdi99pd 1223 5 % % NN cord-015365-iqdi99pd 1223 6 , , , cord-015365-iqdi99pd 1223 7 infection infection NN cord-015365-iqdi99pd 1223 8 rate rate NN cord-015365-iqdi99pd 1223 9 64 64 CD cord-015365-iqdi99pd 1223 10 % % NN cord-015365-iqdi99pd 1223 11 and and CC cord-015365-iqdi99pd 1223 12 surgical surgical JJ cord-015365-iqdi99pd 1223 13 complication complication NN cord-015365-iqdi99pd 1223 14 rate rate NN cord-015365-iqdi99pd 1223 15 50 50 CD cord-015365-iqdi99pd 1223 16 % % NN cord-015365-iqdi99pd 1223 17 . . . cord-015365-iqdi99pd 1224 1 Median median JJ cord-015365-iqdi99pd 1224 2 serum serum NN cord-015365-iqdi99pd 1224 3 creatinine creatinine NN cord-015365-iqdi99pd 1224 4 at at IN cord-015365-iqdi99pd 1224 5 5 5 CD cord-015365-iqdi99pd 1224 6 years year NNS cord-015365-iqdi99pd 1224 7 follow follow VBP cord-015365-iqdi99pd 1224 8 up up RP cord-015365-iqdi99pd 1224 9 was be VBD cord-015365-iqdi99pd 1224 10 1.3 1.3 CD cord-015365-iqdi99pd 1225 1 ( ( -LRB- cord-015365-iqdi99pd 1225 2 range range VBP cord-015365-iqdi99pd 1225 3 0.9 0.9 CD cord-015365-iqdi99pd 1225 4 - - SYM cord-015365-iqdi99pd 1225 5 3.6 3.6 CD cord-015365-iqdi99pd 1225 6 ) ) -RRB- cord-015365-iqdi99pd 1226 1 mg mg NNP cord-015365-iqdi99pd 1226 2 / / SYM cord-015365-iqdi99pd 1226 3 dl dl NNP cord-015365-iqdi99pd 1226 4 and and CC cord-015365-iqdi99pd 1226 5 HbA1c HbA1c NNP cord-015365-iqdi99pd 1226 6 was be VBD cord-015365-iqdi99pd 1226 7 median median JJ cord-015365-iqdi99pd 1226 8 3.2 3.2 CD cord-015365-iqdi99pd 1227 1 ( ( -LRB- cord-015365-iqdi99pd 1227 2 range range VBP cord-015365-iqdi99pd 1227 3 0.9 0.9 CD cord-015365-iqdi99pd 1227 4 - - HYPH cord-015365-iqdi99pd 1227 5 6.1)% 6.1)% NNP cord-015365-iqdi99pd 1227 6 . . . cord-015365-iqdi99pd 1228 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1228 2 . . . cord-015365-iqdi99pd 1229 1 Pancreas pancreas NN cord-015365-iqdi99pd 1229 2 transplantation transplantation NN cord-015365-iqdi99pd 1229 3 seems seem VBZ cord-015365-iqdi99pd 1229 4 to to TO cord-015365-iqdi99pd 1229 5 be be VB cord-015365-iqdi99pd 1229 6 a a DT cord-015365-iqdi99pd 1229 7 good good JJ cord-015365-iqdi99pd 1229 8 therapeutic therapeutic JJ cord-015365-iqdi99pd 1229 9 option option NN cord-015365-iqdi99pd 1229 10 of of IN cord-015365-iqdi99pd 1229 11 selected select VBN cord-015365-iqdi99pd 1229 12 patients patient NNS cord-015365-iqdi99pd 1229 13 with with IN cord-015365-iqdi99pd 1229 14 type type NN cord-015365-iqdi99pd 1229 15 II ii CD cord-015365-iqdi99pd 1229 16 DM dm NN cord-015365-iqdi99pd 1229 17 . . . cord-015365-iqdi99pd 1230 1 Due due IN cord-015365-iqdi99pd 1230 2 to to IN cord-015365-iqdi99pd 1230 3 the the DT cord-015365-iqdi99pd 1230 4 fact fact NN cord-015365-iqdi99pd 1230 5 that that IN cord-015365-iqdi99pd 1230 6 these these DT cord-015365-iqdi99pd 1230 7 patients patient NNS cord-015365-iqdi99pd 1230 8 are be VBP cord-015365-iqdi99pd 1230 9 older old JJR cord-015365-iqdi99pd 1230 10 than than IN cord-015365-iqdi99pd 1230 11 their -PRON- PRP$ cord-015365-iqdi99pd 1230 12 counterparts counterpart NNS cord-015365-iqdi99pd 1230 13 with with IN cord-015365-iqdi99pd 1230 14 type type NN cord-015365-iqdi99pd 1230 15 I -PRON- PRP cord-015365-iqdi99pd 1230 16 DM dm VBP cord-015365-iqdi99pd 1230 17 and and CC cord-015365-iqdi99pd 1230 18 the the DT cord-015365-iqdi99pd 1230 19 fact fact NN cord-015365-iqdi99pd 1230 20 that that IN cord-015365-iqdi99pd 1230 21 we -PRON- PRP cord-015365-iqdi99pd 1230 22 found find VBD cord-015365-iqdi99pd 1230 23 these these DT cord-015365-iqdi99pd 1230 24 patients patient NNS cord-015365-iqdi99pd 1230 25 to to TO cord-015365-iqdi99pd 1230 26 have have VB cord-015365-iqdi99pd 1230 27 a a DT cord-015365-iqdi99pd 1230 28 high high JJ cord-015365-iqdi99pd 1230 29 infection infection NN cord-015365-iqdi99pd 1230 30 rate rate NN cord-015365-iqdi99pd 1230 31 , , , cord-015365-iqdi99pd 1230 32 less less RBR cord-015365-iqdi99pd 1230 33 intensive intensive JJ cord-015365-iqdi99pd 1230 34 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1230 35 regimens regimen NNS cord-015365-iqdi99pd 1230 36 are be VBP cord-015365-iqdi99pd 1230 37 recommended recommend VBN cord-015365-iqdi99pd 1230 38 . . . cord-015365-iqdi99pd 1231 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1231 2 . . . cord-015365-iqdi99pd 1232 1 Von Von NNP cord-015365-iqdi99pd 1232 2 allen allen NNP cord-015365-iqdi99pd 1233 1 1064 1064 CD cord-015365-iqdi99pd 1233 2 Nierentransplantierten Nierentransplantierten NNP cord-015365-iqdi99pd 1233 3 waren waren VBD cord-015365-iqdi99pd 1233 4 132 132 CD cord-015365-iqdi99pd 1234 1 Patienten Patienten NNP cord-015365-iqdi99pd 1234 2 ( ( -LRB- cord-015365-iqdi99pd 1234 3 12 12 CD cord-015365-iqdi99pd 1234 4 % % NN cord-015365-iqdi99pd 1234 5 ) ) -RRB- cord-015365-iqdi99pd 1235 1 Typ-1-oder Typ-1-oder NNP cord-015365-iqdi99pd 1235 2 Typ-2-Diabetiker typ-2-diabetiker NN cord-015365-iqdi99pd 1235 3 und und NNP cord-015365-iqdi99pd 1235 4 hatten hatten NNP cord-015365-iqdi99pd 1236 1 113 113 CD cord-015365-iqdi99pd 1236 2 Patienten Patienten NNP cord-015365-iqdi99pd 1236 3 ( ( -LRB- cord-015365-iqdi99pd 1236 4 11 11 CD cord-015365-iqdi99pd 1236 5 % % NN cord-015365-iqdi99pd 1236 6 ) ) -RRB- cord-015365-iqdi99pd 1236 7 bereits bereits NNP cord-015365-iqdi99pd 1236 8 PTDM PTDM NNP cord-015365-iqdi99pd 1236 9 . . . cord-015365-iqdi99pd 1237 1 Aus Aus NNP cord-015365-iqdi99pd 1237 2 n n NNP cord-015365-iqdi99pd 1237 3 ¼ ¼ NNP cord-015365-iqdi99pd 1237 4 307 307 CD cord-015365-iqdi99pd 1237 5 OGTTs OGTTs NNP cord-015365-iqdi99pd 1237 6 ergab ergab NNP cord-015365-iqdi99pd 1237 7 sich sich NNP cord-015365-iqdi99pd 1237 8 PTDM PTDM NNP cord-015365-iqdi99pd 1237 9 bei bei NNP cord-015365-iqdi99pd 1237 10 29 29 CD cord-015365-iqdi99pd 1238 1 Patienten Patienten NNP cord-015365-iqdi99pd 1238 2 ( ( -LRB- cord-015365-iqdi99pd 1238 3 9 9 CD cord-015365-iqdi99pd 1238 4 % % NN cord-015365-iqdi99pd 1238 5 ) ) -RRB- cord-015365-iqdi99pd 1239 1 und und IN cord-015365-iqdi99pd 1239 2 IGT IGT NNP cord-015365-iqdi99pd 1239 3 bei bei NNP cord-015365-iqdi99pd 1239 4 Patienten Patienten NNP cord-015365-iqdi99pd 1239 5 62 62 CD cord-015365-iqdi99pd 1239 6 ( ( -LRB- cord-015365-iqdi99pd 1239 7 20 20 CD cord-015365-iqdi99pd 1239 8 % % NN cord-015365-iqdi99pd 1239 9 ) ) -RRB- cord-015365-iqdi99pd 1239 10 . . . cord-015365-iqdi99pd 1240 1 Signifikante Signifikante NNP cord-015365-iqdi99pd 1240 2 Prädiktoren Prädiktoren NNP cord-015365-iqdi99pd 1240 3 für für IN cord-015365-iqdi99pd 1240 4 PTDM PTDM NNP cord-015365-iqdi99pd 1241 1 und und NNP cord-015365-iqdi99pd 1241 2 / / SYM cord-015365-iqdi99pd 1241 3 oder oder NNP cord-015365-iqdi99pd 1241 4 IGT IGT NNP cord-015365-iqdi99pd 1241 5 beinhalteten beinhalteten NNP cord-015365-iqdi99pd 1241 6 höheres höheres NNP cord-015365-iqdi99pd 1242 1 Lebensalter Lebensalter NNP cord-015365-iqdi99pd 1242 2 , , , cord-015365-iqdi99pd 1242 3 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 1242 4 mit mit NNP cord-015365-iqdi99pd 1242 5 Tacrolimus Tacrolimus NNP cord-015365-iqdi99pd 1242 6 , , , cord-015365-iqdi99pd 1242 7 höheres höheres NNP cord-015365-iqdi99pd 1243 1 C C NNP cord-015365-iqdi99pd 1243 2 - - HYPH cord-015365-iqdi99pd 1243 3 reaktives reaktive NNS cord-015365-iqdi99pd 1243 4 Protein Protein NNP cord-015365-iqdi99pd 1243 5 und und XX cord-015365-iqdi99pd 1244 1 niedrigeres niedrigeres NNP cord-015365-iqdi99pd 1244 2 Serum Serum NNP cord-015365-iqdi99pd 1244 3 - - HYPH cord-015365-iqdi99pd 1244 4 Albumin Albumin NNP cord-015365-iqdi99pd 1244 5 . . . cord-015365-iqdi99pd 1245 1 OGTTs OGTTs NNP cord-015365-iqdi99pd 1245 2 mit mit NNP cord-015365-iqdi99pd 1245 3 Bestimmung Bestimmung NNP cord-015365-iqdi99pd 1245 4 von von NNP cord-015365-iqdi99pd 1245 5 Insulin Insulin NNP cord-015365-iqdi99pd 1246 1 und und IN cord-015365-iqdi99pd 1246 2 C C NNP cord-015365-iqdi99pd 1246 3 - - HYPH cord-015365-iqdi99pd 1246 4 Peptid Peptid NNP cord-015365-iqdi99pd 1246 5 ( ( -LRB- cord-015365-iqdi99pd 1246 6 n n CC cord-015365-iqdi99pd 1246 7 ¼ ¼ NNP cord-015365-iqdi99pd 1246 8 105 105 CD cord-015365-iqdi99pd 1246 9 ) ) -RRB- cord-015365-iqdi99pd 1247 1 zeigten zeigten NNP cord-015365-iqdi99pd 1248 1 i -PRON- PRP cord-015365-iqdi99pd 1248 2 m be VBP cord-015365-iqdi99pd 1248 3 Vergleich Vergleich NNP cord-015365-iqdi99pd 1248 4 mit mit NNP cord-015365-iqdi99pd 1249 1 1357 1357 CD cord-015365-iqdi99pd 1250 1 OGTTs OGTTs NNP cord-015365-iqdi99pd 1250 2 nicht nicht NNP cord-015365-iqdi99pd 1250 3 - - HYPH cord-015365-iqdi99pd 1250 4 transplantierter transplantierter NNP cord-015365-iqdi99pd 1251 1 Patienten Patienten NNP cord-015365-iqdi99pd 1252 1 ( ( -LRB- cord-015365-iqdi99pd 1252 2 Datensatz Datensatz NNP cord-015365-iqdi99pd 1252 3 G. G. NNP cord-015365-iqdi99pd 1252 4 Pacini Pacini NNP cord-015365-iqdi99pd 1252 5 ) ) -RRB- cord-015365-iqdi99pd 1253 1 eine eine NNP cord-015365-iqdi99pd 1254 1 erhöhte erhöhte NNP cord-015365-iqdi99pd 1254 2 Insulinsensitivität Insulinsensitivität NNP cord-015365-iqdi99pd 1254 3 ( ( -LRB- cord-015365-iqdi99pd 1254 4 OGIS OGIS NNP cord-015365-iqdi99pd 1254 5 : : : cord-015365-iqdi99pd 1255 1 414AE 414AE VBN cord-015365-iqdi99pd 1255 2 67 67 CD cord-015365-iqdi99pd 1255 3 vs. vs. IN cord-015365-iqdi99pd 1255 4 316AE 316AE NNP cord-015365-iqdi99pd 1255 5 53 53 CD cord-015365-iqdi99pd 1256 1 mLÂmin mLÂmin NFP cord-015365-iqdi99pd 1256 2 -1 -1 . cord-015365-iqdi99pd 1257 1 Âm âm XX cord-015365-iqdi99pd 1258 1 -2 -2 LS cord-015365-iqdi99pd 1258 2 ; ; : cord-015365-iqdi99pd 1258 3 ISIcomp ISIcomp NNP cord-015365-iqdi99pd 1258 4 : : : cord-015365-iqdi99pd 1259 1 6,6 6,6 CD cord-015365-iqdi99pd 1259 2 AE AE NNP cord-015365-iqdi99pd 1259 3 4,5 4,5 CD cord-015365-iqdi99pd 1259 4 vs. vs. NN cord-015365-iqdi99pd 1259 5 3,9AE 3,9ae CD cord-015365-iqdi99pd 1259 6 2,4 2,4 CD cord-015365-iqdi99pd 1259 7 , , , cord-015365-iqdi99pd 1260 1 beide beide NNP cord-015365-iqdi99pd 1260 2 p p NN cord-015365-iqdi99pd 1260 3 < < XX cord-015365-iqdi99pd 1260 4 0,001 0,001 CD cord-015365-iqdi99pd 1260 5 ) ) -RRB- cord-015365-iqdi99pd 1260 6 . . . cord-015365-iqdi99pd 1261 1 Diese Diese NNP cord-015365-iqdi99pd 1261 2 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1261 3 waren waren VBD cord-015365-iqdi99pd 1261 4 in in IN cord-015365-iqdi99pd 1261 5 Sensitivitäts Sensitivitäts NNP cord-015365-iqdi99pd 1261 6 - - HYPH cord-015365-iqdi99pd 1261 7 Analysen Analysen NNP cord-015365-iqdi99pd 1261 8 gematchter gematchter NN cord-015365-iqdi99pd 1261 9 OGTTs ogtt NNS cord-015365-iqdi99pd 1261 10 ( ( -LRB- cord-015365-iqdi99pd 1261 11 nach nach NNP cord-015365-iqdi99pd 1261 12 Alter Alter NNP cord-015365-iqdi99pd 1261 13 , , , cord-015365-iqdi99pd 1261 14 BMI BMI NNP cord-015365-iqdi99pd 1261 15 , , , cord-015365-iqdi99pd 1261 16 Geschlecht Geschlecht NNP cord-015365-iqdi99pd 1261 17 , , , cord-015365-iqdi99pd 1261 18 2h 2h CD cord-015365-iqdi99pd 1261 19 - - : cord-015365-iqdi99pd 1261 20 Blutzucker Blutzucker NNP cord-015365-iqdi99pd 1261 21 i -PRON- PRP cord-015365-iqdi99pd 1261 22 m be VBP cord-015365-iqdi99pd 1261 23 OGTT OGTT NNP cord-015365-iqdi99pd 1261 24 ) ) -RRB- cord-015365-iqdi99pd 1261 25 konsistent konsistent NNP cord-015365-iqdi99pd 1261 26 , , , cord-015365-iqdi99pd 1261 27 des des NNP cord-015365-iqdi99pd 1261 28 weiteren weiteren NNP cord-015365-iqdi99pd 1261 29 hatten hatten NNP cord-015365-iqdi99pd 1262 1 Nierentransplantierte Nierentransplantierte NNP cord-015365-iqdi99pd 1262 2 mit mit NNP cord-015365-iqdi99pd 1262 3 Normoglykämie Normoglykämie NNP cord-015365-iqdi99pd 1262 4 ( ( -LRB- cord-015365-iqdi99pd 1262 5 2h 2h NNP cord-015365-iqdi99pd 1262 6 - - HYPH cord-015365-iqdi99pd 1262 7 Blutzucker Blutzucker NNP cord-015365-iqdi99pd 1263 1 i -PRON- PRP cord-015365-iqdi99pd 1263 2 m be VBP cord-015365-iqdi99pd 1263 3 OGTT OGTT NNP cord-015365-iqdi99pd 1264 1 < < XX cord-015365-iqdi99pd 1264 2 140 140 CD cord-015365-iqdi99pd 1265 1 mg mg NNP cord-015365-iqdi99pd 1265 2 / / SYM cord-015365-iqdi99pd 1265 3 dL dl NN cord-015365-iqdi99pd 1265 4 ) ) -RRB- cord-015365-iqdi99pd 1265 5 ebenso ebenso NNP cord-015365-iqdi99pd 1265 6 wie wie NNP cord-015365-iqdi99pd 1265 7 mit mit NNP cord-015365-iqdi99pd 1265 8 Hyperglykämie Hyperglykämie NNP cord-015365-iqdi99pd 1265 9 ( ( -LRB- cord-015365-iqdi99pd 1265 10 2h 2h NNP cord-015365-iqdi99pd 1265 11 - - HYPH cord-015365-iqdi99pd 1265 12 Blutzucker Blutzucker NNP cord-015365-iqdi99pd 1266 1 i -PRON- PRP cord-015365-iqdi99pd 1266 2 m be VBP cord-015365-iqdi99pd 1266 3 OGTT OGTT NNP cord-015365-iqdi99pd 1266 4 140 140 CD cord-015365-iqdi99pd 1266 5 - - SYM cord-015365-iqdi99pd 1266 6 199 199 CD cord-015365-iqdi99pd 1267 1 mg mg NNP cord-015365-iqdi99pd 1267 2 / / SYM cord-015365-iqdi99pd 1267 3 dl dl NNP cord-015365-iqdi99pd 1267 4 bzw bzw NNP cord-015365-iqdi99pd 1267 5 . . . cord-015365-iqdi99pd 1268 1 > > XX cord-015365-iqdi99pd 1269 1 200 200 CD cord-015365-iqdi99pd 1269 2 mg/ mg/ NN cord-015365-iqdi99pd 1269 3 dL dl NN cord-015365-iqdi99pd 1269 4 ) ) -RRB- cord-015365-iqdi99pd 1270 1 signifikant signifikant NNP cord-015365-iqdi99pd 1270 2 bessere bessere NNP cord-015365-iqdi99pd 1270 3 Insulinsensitivität Insulinsensitivität NNP cord-015365-iqdi99pd 1270 4 als als NN cord-015365-iqdi99pd 1270 5 die die VBP cord-015365-iqdi99pd 1270 6 Normalbevölkerung Normalbevölkerung NNP cord-015365-iqdi99pd 1270 7 ohne ohne NNP cord-015365-iqdi99pd 1270 8 oder oder NNP cord-015365-iqdi99pd 1270 9 mit mit NNP cord-015365-iqdi99pd 1270 10 IGT IGT NNP cord-015365-iqdi99pd 1270 11 bzw bzw NNP cord-015365-iqdi99pd 1270 12 . . . cord-015365-iqdi99pd 1271 1 Typ-2-Diabetes Typ-2-Diabetes NNP cord-015365-iqdi99pd 1271 2 . . . cord-015365-iqdi99pd 1272 1 Die die VB cord-015365-iqdi99pd 1272 2 Regressions regression NNS cord-015365-iqdi99pd 1272 3 - - HYPH cord-015365-iqdi99pd 1272 4 Kurven Kurven NNP cord-015365-iqdi99pd 1272 5 der der NNP cord-015365-iqdi99pd 1272 6 Insulin Insulin NNP cord-015365-iqdi99pd 1272 7 - - HYPH cord-015365-iqdi99pd 1272 8 Ausschüttung Ausschüttung NNP cord-015365-iqdi99pd 1272 9 und und IN cord-015365-iqdi99pd 1272 10 des des NNP cord-015365-iqdi99pd 1272 11 insulinogenen insulinogenen NNP cord-015365-iqdi99pd 1272 12 Index Index NNP cord-015365-iqdi99pd 1272 13 , , , cord-015365-iqdi99pd 1272 14 aufgetragen aufgetragen NNP cord-015365-iqdi99pd 1272 15 gegen gegen NNP cord-015365-iqdi99pd 1272 16 den den NNP cord-015365-iqdi99pd 1272 17 2h 2h NNP cord-015365-iqdi99pd 1272 18 - - HYPH cord-015365-iqdi99pd 1272 19 Blutzucker Blutzucker NNP cord-015365-iqdi99pd 1273 1 i -PRON- PRP cord-015365-iqdi99pd 1273 2 m be VBP cord-015365-iqdi99pd 1273 3 OGTT OGTT NNP cord-015365-iqdi99pd 1273 4 , , , cord-015365-iqdi99pd 1273 5 wiesen wiesen NNP cord-015365-iqdi99pd 1273 6 zwischen zwischen NNP cord-015365-iqdi99pd 1273 7 Transplantierten Transplantierten NNP cord-015365-iqdi99pd 1273 8 und und IN cord-015365-iqdi99pd 1274 1 Nicht Nicht NNP cord-015365-iqdi99pd 1274 2 - - HYPH cord-015365-iqdi99pd 1274 3 Transplantierten Transplantierten NNP cord-015365-iqdi99pd 1274 4 eindeutige eindeutige VBZ cord-015365-iqdi99pd 1274 5 Unterschiede Unterschiede NNP cord-015365-iqdi99pd 1274 6 auf auf NNP cord-015365-iqdi99pd 1274 7 , , , cord-015365-iqdi99pd 1274 8 mit mit NNP cord-015365-iqdi99pd 1274 9 besonders besonders NNP cord-015365-iqdi99pd 1274 10 starkem starkem NNP cord-015365-iqdi99pd 1274 11 Abfall Abfall NNP cord-015365-iqdi99pd 1274 12 der der NNP cord-015365-iqdi99pd 1274 13 Insulinsekretion Insulinsekretion NNP cord-015365-iqdi99pd 1274 14 bei bei NNP cord-015365-iqdi99pd 1274 15 Nierentransplantierten Nierentransplantierten NNP cord-015365-iqdi99pd 1275 1 mit mit NNP cord-015365-iqdi99pd 1275 2 2h 2h NNP cord-015365-iqdi99pd 1275 3 - - HYPH cord-015365-iqdi99pd 1275 4 Blutzucker Blutzucker NNP cord-015365-iqdi99pd 1275 5 - - HYPH cord-015365-iqdi99pd 1275 6 Werten Werten NNP cord-015365-iqdi99pd 1276 1 > > XX cord-015365-iqdi99pd 1277 1 200 200 CD cord-015365-iqdi99pd 1277 2 mg mg NNP cord-015365-iqdi99pd 1277 3 / / SYM cord-015365-iqdi99pd 1277 4 dL dl NN cord-015365-iqdi99pd 1278 1 ( ( -LRB- cord-015365-iqdi99pd 1278 2 Insulin insulin NN cord-015365-iqdi99pd 1278 3 - - HYPH cord-015365-iqdi99pd 1278 4 area area NN cord-015365-iqdi99pd 1278 5 under under IN cord-015365-iqdi99pd 1278 6 the the DT cord-015365-iqdi99pd 1278 7 curve curve NN cord-015365-iqdi99pd 1279 1 ( ( -LRB- cord-015365-iqdi99pd 1279 2 AUC AUC NNP cord-015365-iqdi99pd 1279 3 ) ) -RRB- cord-015365-iqdi99pd 1279 4 3,4 3,4 CD cord-015365-iqdi99pd 1279 5 AE AE NNP cord-015365-iqdi99pd 1279 6 1,9 1,9 CD cord-015365-iqdi99pd 1279 7 vs. vs. NN cord-015365-iqdi99pd 1279 8 6,1 6,1 CD cord-015365-iqdi99pd 1280 1 AE AE NNP cord-015365-iqdi99pd 1280 2 3,4 3,4 CD cord-015365-iqdi99pd 1281 1 mU mU NNP cord-015365-iqdi99pd 1281 2 / / SYM cord-015365-iqdi99pd 1281 3 mL mL NNP cord-015365-iqdi99pd 1281 4 2h 2h NN cord-015365-iqdi99pd 1281 5 , , , cord-015365-iqdi99pd 1281 6 p p NN cord-015365-iqdi99pd 1281 7 ¼ ¼ NNP cord-015365-iqdi99pd 1281 8 0,002 0,002 CD cord-015365-iqdi99pd 1281 9 ) ) -RRB- cord-015365-iqdi99pd 1281 10 . . . cord-015365-iqdi99pd 1282 1 Eine Eine NNP cord-015365-iqdi99pd 1282 2 Validierung Validierung NNP cord-015365-iqdi99pd 1282 3 aller aller NNP cord-015365-iqdi99pd 1282 4 verwendeter verwendeter NN cord-015365-iqdi99pd 1283 1 OGTT OGTT NNP cord-015365-iqdi99pd 1283 2 - - HYPH cord-015365-iqdi99pd 1283 3 Indizes Indizes NNP cord-015365-iqdi99pd 1283 4 erfolgte erfolgte NN cord-015365-iqdi99pd 1284 1 anhand anhand NNP cord-015365-iqdi99pd 1284 2 23 23 CD cord-015365-iqdi99pd 1285 1 euglykämisch euglykämisch NNP cord-015365-iqdi99pd 1285 2 - - HYPH cord-015365-iqdi99pd 1285 3 hyperinsulinämischer hyperinsulinämischer NNP cord-015365-iqdi99pd 1285 4 Clamps Clamps NNP cord-015365-iqdi99pd 1285 5 . . . cord-015365-iqdi99pd 1286 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 1286 2 . . . cord-015365-iqdi99pd 1287 1 Insulin Insulin NNP cord-015365-iqdi99pd 1287 2 - - HYPH cord-015365-iqdi99pd 1287 3 Sekretionsverlust Sekretionsverlust NNP cord-015365-iqdi99pd 1287 4 könnte könnte FW cord-015365-iqdi99pd 1287 5 das das NNP cord-015365-iqdi99pd 1287 6 dominante dominante NNP cord-015365-iqdi99pd 1287 7 Problem Problem NNP cord-015365-iqdi99pd 1287 8 bei bei NNP cord-015365-iqdi99pd 1287 9 der der NNP cord-015365-iqdi99pd 1287 10 Entwicklung Entwicklung NNP cord-015365-iqdi99pd 1287 11 eines eine NNS cord-015365-iqdi99pd 1288 1 PTDM PTDM NNP cord-015365-iqdi99pd 1288 2 nach nach NNP cord-015365-iqdi99pd 1288 3 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 1288 4 sein sein NNP cord-015365-iqdi99pd 1288 5 und und NNP cord-015365-iqdi99pd 1288 6 verlangt verlangt NNP cord-015365-iqdi99pd 1289 1 nach nach NNP cord-015365-iqdi99pd 1289 2 therapeutischen therapeutischen NNP cord-015365-iqdi99pd 1289 3 Strategien Strategien NNP cord-015365-iqdi99pd 1289 4 zum zum NNP cord-015365-iqdi99pd 1289 5 Schutz Schutz NNP cord-015365-iqdi99pd 1289 6 der der NNP cord-015365-iqdi99pd 1289 7 Betazellen Betazellen NNP cord-015365-iqdi99pd 1289 8 . . . cord-015365-iqdi99pd 1290 1 Hämoglobinvariabilität Hämoglobinvariabilität NNP cord-015365-iqdi99pd 1290 2 ist ist NN cord-015365-iqdi99pd 1290 3 assoziiert assoziiert NN cord-015365-iqdi99pd 1290 4 mit mit NNP cord-015365-iqdi99pd 1290 5 Mortalität Mortalität NNP cord-015365-iqdi99pd 1290 6 nach nach NNP cord-015365-iqdi99pd 1290 7 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 1290 8 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1290 9 . . . cord-015365-iqdi99pd 1291 1 Die die VB cord-015365-iqdi99pd 1291 2 Hazard Hazard NNP cord-015365-iqdi99pd 1291 3 Ratio Ratio NNP cord-015365-iqdi99pd 1291 4 ( ( -LRB- cord-015365-iqdi99pd 1291 5 HR HR NNP cord-015365-iqdi99pd 1291 6 ) ) -RRB- cord-015365-iqdi99pd 1292 1 fü fü IN cord-015365-iqdi99pd 1293 1 r r NNP cord-015365-iqdi99pd 1293 2 Mortalität Mortalität NNP cord-015365-iqdi99pd 1293 3 und und XX cord-015365-iqdi99pd 1294 1 Transplantatversagen Transplantatversagen NNP cord-015365-iqdi99pd 1294 2 stieg stieg NNP cord-015365-iqdi99pd 1294 3 signifikant signifikant NNP cord-015365-iqdi99pd 1294 4 mit mit NNP cord-015365-iqdi99pd 1294 5 der der NNP cord-015365-iqdi99pd 1294 6 Hämoglobinvariabilität Hämoglobinvariabilität NNP cord-015365-iqdi99pd 1295 1 an an DT cord-015365-iqdi99pd 1295 2 . . . cord-015365-iqdi99pd 1296 1 I -PRON- PRP cord-015365-iqdi99pd 1296 2 m be VBP cord-015365-iqdi99pd 1296 3 linearen linearen NNP cord-015365-iqdi99pd 1296 4 Modell Modell NNP cord-015365-iqdi99pd 1296 5 betrug betrug NNP cord-015365-iqdi99pd 1296 6 der der NNP cord-015365-iqdi99pd 1296 7 Anstieg Anstieg NNP cord-015365-iqdi99pd 1297 1 fü fü TO cord-015365-iqdi99pd 1297 2 r r LS cord-015365-iqdi99pd 1297 3 die die VB cord-015365-iqdi99pd 1298 1 Mortalität Mortalität NNS cord-015365-iqdi99pd 1298 2 2,35 2,35 CD cord-015365-iqdi99pd 1299 1 ( ( -LRB- cord-015365-iqdi99pd 1299 2 95 95 CD cord-015365-iqdi99pd 1299 3 % % NN cord-015365-iqdi99pd 1300 1 Konfidenzintervall Konfidenzintervall NNP cord-015365-iqdi99pd 1300 2 1,75 1,75 CD cord-015365-iqdi99pd 1300 3 - - HYPH cord-015365-iqdi99pd 1300 4 3,17 3,17 NN cord-015365-iqdi99pd 1300 5 ; ; : cord-015365-iqdi99pd 1300 6 p p NN cord-015365-iqdi99pd 1300 7 < < XX cord-015365-iqdi99pd 1300 8 0,001 0,001 CD cord-015365-iqdi99pd 1300 9 ) ) -RRB- cord-015365-iqdi99pd 1300 10 , , , cord-015365-iqdi99pd 1300 11 fü fü IN cord-015365-iqdi99pd 1300 12 r r NN cord-015365-iqdi99pd 1300 13 das das NNP cord-015365-iqdi99pd 1300 14 funktionelle funktionelle NNP cord-015365-iqdi99pd 1301 1 Transplantatversagen Transplantatversagen NNP cord-015365-iqdi99pd 1301 2 2,45 2,45 CD cord-015365-iqdi99pd 1301 3 ( ( -LRB- cord-015365-iqdi99pd 1301 4 1,76 1,76 CD cord-015365-iqdi99pd 1301 5 - - HYPH cord-015365-iqdi99pd 1301 6 3,40 3,40 CD cord-015365-iqdi99pd 1301 7 ; ; . cord-015365-iqdi99pd 1302 1 p p LS cord-015365-iqdi99pd 1302 2 < < XX cord-015365-iqdi99pd 1302 3 0,001 0,001 CD cord-015365-iqdi99pd 1302 4 ) ) -RRB- cord-015365-iqdi99pd 1302 5 . . . cord-015365-iqdi99pd 1303 1 In in IN cord-015365-iqdi99pd 1303 2 einem einem NNP cord-015365-iqdi99pd 1303 3 klinischen klinischen FW cord-015365-iqdi99pd 1303 4 Expertenmodell Expertenmodell NNP cord-015365-iqdi99pd 1303 5 , , , cord-015365-iqdi99pd 1303 6 das das NNP cord-015365-iqdi99pd 1303 7 fü fü IN cord-015365-iqdi99pd 1303 8 r r NN cord-015365-iqdi99pd 1303 9 die die VB cord-015365-iqdi99pd 1303 10 Verwendung Verwendung NNP cord-015365-iqdi99pd 1303 11 von von NNP cord-015365-iqdi99pd 1303 12 ESA ESA NNP cord-015365-iqdi99pd 1303 13 , , , cord-015365-iqdi99pd 1303 14 Hämoglobin Hämoglobin NNP cord-015365-iqdi99pd 1303 15 , , , cord-015365-iqdi99pd 1303 16 Alter Alter NNP cord-015365-iqdi99pd 1303 17 bei bei NNP cord-015365-iqdi99pd 1303 18 der der NNP cord-015365-iqdi99pd 1303 19 Transplantation Transplantation NNP cord-015365-iqdi99pd 1303 20 , , , cord-015365-iqdi99pd 1303 21 Diabetes diabetes NN cord-015365-iqdi99pd 1303 22 , , , cord-015365-iqdi99pd 1303 23 Tage Tage NNP cord-015365-iqdi99pd 1303 24 an an DT cord-015365-iqdi99pd 1303 25 der der NN cord-015365-iqdi99pd 1303 26 Dialyse Dialyse NNP cord-015365-iqdi99pd 1303 27 , , , cord-015365-iqdi99pd 1303 28 glomeruläre glomeruläre NNP cord-015365-iqdi99pd 1303 29 Filtrationsrate Filtrationsrate NNP cord-015365-iqdi99pd 1303 30 , , , cord-015365-iqdi99pd 1303 31 Abstoßung Abstoßung NNP cord-015365-iqdi99pd 1303 32 und und IN cord-015365-iqdi99pd 1303 33 Jahr Jahr NNP cord-015365-iqdi99pd 1303 34 der der NNP cord-015365-iqdi99pd 1303 35 Transplantation Transplantation NNP cord-015365-iqdi99pd 1303 36 adjustiert adjustiert NN cord-015365-iqdi99pd 1303 37 wurde wurde NN cord-015365-iqdi99pd 1303 38 , , , cord-015365-iqdi99pd 1303 39 war war NN cord-015365-iqdi99pd 1304 1 die die VB cord-015365-iqdi99pd 1305 1 Hämoglobinvariabilität Hämoglobinvariabilität NNP cord-015365-iqdi99pd 1305 2 mit mit VBP cord-015365-iqdi99pd 1305 3 der der NNP cord-015365-iqdi99pd 1305 4 Mortalität Mortalität NNP cord-015365-iqdi99pd 1305 5 assoziiert assoziiert NN cord-015365-iqdi99pd 1305 6 ( ( -LRB- cord-015365-iqdi99pd 1305 7 HR hr NN cord-015365-iqdi99pd 1305 8 : : : cord-015365-iqdi99pd 1305 9 2,11 2,11 CD cord-015365-iqdi99pd 1305 10 ; ; . cord-015365-iqdi99pd 1306 1 1,51 1,51 CD cord-015365-iqdi99pd 1306 2 - - HYPH cord-015365-iqdi99pd 1306 3 2,94 2,94 CD cord-015365-iqdi99pd 1306 4 ; ; : cord-015365-iqdi99pd 1306 5 p p NN cord-015365-iqdi99pd 1306 6 < < XX cord-015365-iqdi99pd 1306 7 0,001 0,001 CD cord-015365-iqdi99pd 1306 8 ) ) -RRB- cord-015365-iqdi99pd 1306 9 , , , cord-015365-iqdi99pd 1306 10 jedoch jedoch NNP cord-015365-iqdi99pd 1306 11 nicht nicht NNP cord-015365-iqdi99pd 1306 12 fü fü NNP cord-015365-iqdi99pd 1307 1 r r NNP cord-015365-iqdi99pd 1307 2 das das NNP cord-015365-iqdi99pd 1308 1 funktionelle funktionelle NNP cord-015365-iqdi99pd 1308 2 Transplantatversagen Transplantatversagen NNP cord-015365-iqdi99pd 1308 3 ( ( -LRB- cord-015365-iqdi99pd 1308 4 HR HR NNP cord-015365-iqdi99pd 1308 5 : : : cord-015365-iqdi99pd 1308 6 1,34 1,34 CD cord-015365-iqdi99pd 1308 7 ; ; : cord-015365-iqdi99pd 1308 8 0,93 0,93 CD cord-015365-iqdi99pd 1308 9 - - HYPH cord-015365-iqdi99pd 1308 10 1,93 1,93 CD cord-015365-iqdi99pd 1308 11 ; ; : cord-015365-iqdi99pd 1308 12 p p NN cord-015365-iqdi99pd 1308 13 ¼ ¼ NNP cord-015365-iqdi99pd 1308 14 0,121 0,121 CD cord-015365-iqdi99pd 1308 15 ) ) -RRB- cord-015365-iqdi99pd 1308 16 . . . cord-015365-iqdi99pd 1309 1 Ein Ein NNP cord-015365-iqdi99pd 1309 2 ähnliches ähnliches NNP cord-015365-iqdi99pd 1310 1 Ergebnis Ergebnis NNP cord-015365-iqdi99pd 1310 2 erhielten erhielten NNP cord-015365-iqdi99pd 1311 1 wir wir NNP cord-015365-iqdi99pd 1311 2 beim beim NNP cord-015365-iqdi99pd 1311 3 Purposeful Purposeful NNP cord-015365-iqdi99pd 1311 4 Selection Selection NNP cord-015365-iqdi99pd 1311 5 Modell Modell NNP cord-015365-iqdi99pd 1311 6 : : : cord-015365-iqdi99pd 1312 1 Die die VB cord-015365-iqdi99pd 1313 1 Hämoglobinvariabilität Hämoglobinvariabilität NNP cord-015365-iqdi99pd 1313 2 war war NN cord-015365-iqdi99pd 1313 3 signifikant signifikant NN cord-015365-iqdi99pd 1313 4 assoziiert assoziiert NNP cord-015365-iqdi99pd 1313 5 mit mit NNP cord-015365-iqdi99pd 1313 6 Mortalität Mortalität NNP cord-015365-iqdi99pd 1313 7 ( ( -LRB- cord-015365-iqdi99pd 1313 8 HR HR NNP cord-015365-iqdi99pd 1313 9 : : : cord-015365-iqdi99pd 1313 10 2,63 2,63 CD cord-015365-iqdi99pd 1313 11 ; ; . cord-015365-iqdi99pd 1314 1 1,70 1,70 NNP cord-015365-iqdi99pd 1314 2 - - HYPH cord-015365-iqdi99pd 1314 3 4,08 4,08 CD cord-015365-iqdi99pd 1314 4 ; ; . cord-015365-iqdi99pd 1315 1 p p LS cord-015365-iqdi99pd 1315 2 < < XX cord-015365-iqdi99pd 1315 3 0,001 0,001 CD cord-015365-iqdi99pd 1315 4 ) ) -RRB- cord-015365-iqdi99pd 1315 5 und und RB cord-015365-iqdi99pd 1316 1 nicht nicht NNP cord-015365-iqdi99pd 1316 2 signifikant signifikant NNP cord-015365-iqdi99pd 1316 3 mit mit NNP cord-015365-iqdi99pd 1316 4 dem dem NNP cord-015365-iqdi99pd 1316 5 funktionellen funktionellen NNP cord-015365-iqdi99pd 1316 6 Transplantatversagen Transplantatversagen NNP cord-015365-iqdi99pd 1316 7 ( ( -LRB- cord-015365-iqdi99pd 1316 8 HR HR NNP cord-015365-iqdi99pd 1316 9 : : : cord-015365-iqdi99pd 1316 10 1,27 1,27 CD cord-015365-iqdi99pd 1316 11 ; ; : cord-015365-iqdi99pd 1317 1 0,63 0,63 CD cord-015365-iqdi99pd 1317 2 - - HYPH cord-015365-iqdi99pd 1317 3 2,54 2,54 CD cord-015365-iqdi99pd 1317 4 ; ; : cord-015365-iqdi99pd 1317 5 p p NN cord-015365-iqdi99pd 1317 6 ¼ ¼ NNP cord-015365-iqdi99pd 1317 7 0,509 0,509 CD cord-015365-iqdi99pd 1317 8 ) ) -RRB- cord-015365-iqdi99pd 1317 9 . . . cord-015365-iqdi99pd 1318 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 1318 2 . . . cord-015365-iqdi99pd 1319 1 Hämoglobinvariabilität Hämoglobinvariabilität NNP cord-015365-iqdi99pd 1319 2 unter unter JJ cord-015365-iqdi99pd 1319 3 ESA ESA NNP cord-015365-iqdi99pd 1319 4 Therapie Therapie NNP cord-015365-iqdi99pd 1319 5 nach nach NN cord-015365-iqdi99pd 1319 6 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 1319 7 ist ist NN cord-015365-iqdi99pd 1319 8 mit mit NNP cord-015365-iqdi99pd 1319 9 erhöhter erhöhter NNP cord-015365-iqdi99pd 1319 10 Mortalität Mortalität NNP cord-015365-iqdi99pd 1319 11 assoziiert assoziiert NN cord-015365-iqdi99pd 1319 12 . . . cord-015365-iqdi99pd 1320 1 Influence influence NN cord-015365-iqdi99pd 1320 2 of of IN cord-015365-iqdi99pd 1320 3 recipient recipient NN cord-015365-iqdi99pd 1320 4 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1320 5 genotypes genotype NNS cord-015365-iqdi99pd 1320 6 on on IN cord-015365-iqdi99pd 1320 7 the the DT cord-015365-iqdi99pd 1320 8 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 1320 9 of of IN cord-015365-iqdi99pd 1320 10 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1320 11 in in IN cord-015365-iqdi99pd 1320 12 liver liver NN cord-015365-iqdi99pd 1320 13 transplant transplant NN cord-015365-iqdi99pd 1320 14 recipients recipient NNS cord-015365-iqdi99pd 1320 15 Background Background NNP cord-015365-iqdi99pd 1320 16 . . . cord-015365-iqdi99pd 1321 1 Tacrolimus Tacrolimus NNP cord-015365-iqdi99pd 1321 2 , , , cord-015365-iqdi99pd 1321 3 which which WDT cord-015365-iqdi99pd 1321 4 is be VBZ cord-015365-iqdi99pd 1321 5 widely widely RB cord-015365-iqdi99pd 1321 6 used use VBN cord-015365-iqdi99pd 1321 7 in in IN cord-015365-iqdi99pd 1321 8 liver liver NN cord-015365-iqdi99pd 1321 9 transplant transplant NN cord-015365-iqdi99pd 1321 10 recipients recipient NNS cord-015365-iqdi99pd 1321 11 , , , cord-015365-iqdi99pd 1321 12 shows show VBZ cord-015365-iqdi99pd 1321 13 high high JJ cord-015365-iqdi99pd 1321 14 interindividual interindividual JJ cord-015365-iqdi99pd 1321 15 variability variability NN cord-015365-iqdi99pd 1321 16 in in IN cord-015365-iqdi99pd 1321 17 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 1321 18 . . . cord-015365-iqdi99pd 1322 1 It -PRON- PRP cord-015365-iqdi99pd 1322 2 is be VBZ cord-015365-iqdi99pd 1322 3 primarily primarily RB cord-015365-iqdi99pd 1322 4 metabolized metabolize VBN cord-015365-iqdi99pd 1322 5 by by IN cord-015365-iqdi99pd 1322 6 hepatic hepatic JJ cord-015365-iqdi99pd 1322 7 cytochrome cytochrome NN cord-015365-iqdi99pd 1322 8 P450 P450 NNP cord-015365-iqdi99pd 1322 9 3A4 3A4 NNPS cord-015365-iqdi99pd 1322 10 and and CC cord-015365-iqdi99pd 1322 11 3A5 3a5 CD cord-015365-iqdi99pd 1322 12 ( ( -LRB- cord-015365-iqdi99pd 1322 13 CYP CYP NNP cord-015365-iqdi99pd 1322 14 ) ) -RRB- cord-015365-iqdi99pd 1322 15 . . . cord-015365-iqdi99pd 1323 1 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1323 2 is be VBZ cord-015365-iqdi99pd 1323 3 also also RB cord-015365-iqdi99pd 1323 4 expressed express VBN cord-015365-iqdi99pd 1323 5 in in IN cord-015365-iqdi99pd 1323 6 the the DT cord-015365-iqdi99pd 1323 7 kidney kidney NN cord-015365-iqdi99pd 1323 8 and and CC cord-015365-iqdi99pd 1323 9 in in IN cord-015365-iqdi99pd 1323 10 the the DT cord-015365-iqdi99pd 1323 11 intestine intestine NN cord-015365-iqdi99pd 1323 12 . . . cord-015365-iqdi99pd 1324 1 In in IN cord-015365-iqdi99pd 1324 2 this this DT cord-015365-iqdi99pd 1324 3 study study NN cord-015365-iqdi99pd 1324 4 , , , cord-015365-iqdi99pd 1324 5 we -PRON- PRP cord-015365-iqdi99pd 1324 6 evaluated evaluate VBD cord-015365-iqdi99pd 1324 7 the the DT cord-015365-iqdi99pd 1324 8 influence influence NN cord-015365-iqdi99pd 1324 9 of of IN cord-015365-iqdi99pd 1324 10 recipient recipient NN cord-015365-iqdi99pd 1324 11 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1324 12 genotypes genotype NNS cord-015365-iqdi99pd 1324 13 on on IN cord-015365-iqdi99pd 1324 14 the the DT cord-015365-iqdi99pd 1324 15 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 1324 16 of of IN cord-015365-iqdi99pd 1324 17 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1324 18 in in IN cord-015365-iqdi99pd 1324 19 patients patient NNS cord-015365-iqdi99pd 1324 20 after after IN cord-015365-iqdi99pd 1324 21 liver liver NN cord-015365-iqdi99pd 1324 22 transplantation transplantation NN cord-015365-iqdi99pd 1324 23 . . . cord-015365-iqdi99pd 1325 1 Methods method NNS cord-015365-iqdi99pd 1325 2 . . . cord-015365-iqdi99pd 1326 1 Patients patient NNS cord-015365-iqdi99pd 1326 2 after after IN cord-015365-iqdi99pd 1326 3 liver liver NN cord-015365-iqdi99pd 1326 4 transplantation transplantation NN cord-015365-iqdi99pd 1326 5 with with IN cord-015365-iqdi99pd 1326 6 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1326 7 maintenance maintenance NN cord-015365-iqdi99pd 1326 8 therapy therapy NN cord-015365-iqdi99pd 1326 9 were be VBD cord-015365-iqdi99pd 1326 10 included include VBN cord-015365-iqdi99pd 1326 11 into into IN cord-015365-iqdi99pd 1326 12 the the DT cord-015365-iqdi99pd 1326 13 study study NN cord-015365-iqdi99pd 1326 14 . . . cord-015365-iqdi99pd 1327 1 CYP3A5 cyp3a5 JJ cord-015365-iqdi99pd 1327 2 genotypes genotype NNS cord-015365-iqdi99pd 1327 3 of of IN cord-015365-iqdi99pd 1327 4 the the DT cord-015365-iqdi99pd 1327 5 recipients recipient NNS cord-015365-iqdi99pd 1327 6 were be VBD cord-015365-iqdi99pd 1327 7 established establish VBN cord-015365-iqdi99pd 1327 8 . . . cord-015365-iqdi99pd 1328 1 Clinical clinical JJ cord-015365-iqdi99pd 1328 2 and and CC cord-015365-iqdi99pd 1328 3 laboratory laboratory NN cord-015365-iqdi99pd 1328 4 data datum NNS cord-015365-iqdi99pd 1328 5 at at IN cord-015365-iqdi99pd 1328 6 various various JJ cord-015365-iqdi99pd 1328 7 time time NN cord-015365-iqdi99pd 1328 8 points point NNS cord-015365-iqdi99pd 1328 9 ( ( -LRB- cord-015365-iqdi99pd 1328 10 1 1 CD cord-015365-iqdi99pd 1328 11 month month NN cord-015365-iqdi99pd 1328 12 , , , cord-015365-iqdi99pd 1328 13 3 3 CD cord-015365-iqdi99pd 1328 14 months month NNS cord-015365-iqdi99pd 1328 15 , , , cord-015365-iqdi99pd 1328 16 1 1 CD cord-015365-iqdi99pd 1328 17 year year NN cord-015365-iqdi99pd 1328 18 and and CC cord-015365-iqdi99pd 1328 19 3 3 CD cord-015365-iqdi99pd 1328 20 years year NNS cord-015365-iqdi99pd 1328 21 after after IN cord-015365-iqdi99pd 1328 22 start start NN cord-015365-iqdi99pd 1328 23 of of IN cord-015365-iqdi99pd 1328 24 medication medication NN cord-015365-iqdi99pd 1328 25 with with IN cord-015365-iqdi99pd 1328 26 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1328 27 ) ) -RRB- cord-015365-iqdi99pd 1328 28 were be VBD cord-015365-iqdi99pd 1328 29 evaluated evaluate VBN cord-015365-iqdi99pd 1328 30 retrospectively retrospectively RB cord-015365-iqdi99pd 1328 31 . . . cord-015365-iqdi99pd 1329 1 Doses dose NNS cord-015365-iqdi99pd 1329 2 and and CC cord-015365-iqdi99pd 1329 3 trough trough NN cord-015365-iqdi99pd 1329 4 levels level NNS cord-015365-iqdi99pd 1329 5 of of IN cord-015365-iqdi99pd 1329 6 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1329 7 were be VBD cord-015365-iqdi99pd 1329 8 noted note VBN cord-015365-iqdi99pd 1329 9 and and CC cord-015365-iqdi99pd 1329 10 a a DT cord-015365-iqdi99pd 1329 11 screening screening NN cord-015365-iqdi99pd 1329 12 of of IN cord-015365-iqdi99pd 1329 13 all all DT cord-015365-iqdi99pd 1329 14 concomitant concomitant JJ cord-015365-iqdi99pd 1329 15 medications medication NNS cord-015365-iqdi99pd 1329 16 with with IN cord-015365-iqdi99pd 1329 17 possible possible JJ cord-015365-iqdi99pd 1329 18 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1329 19 interaction interaction NN cord-015365-iqdi99pd 1329 20 was be VBD cord-015365-iqdi99pd 1329 21 performed perform VBN cord-015365-iqdi99pd 1329 22 . . . cord-015365-iqdi99pd 1330 1 SPSS SPSS NNP cord-015365-iqdi99pd 1330 2 for for IN cord-015365-iqdi99pd 1330 3 windows window NNS cord-015365-iqdi99pd 1330 4 ( ( -LRB- cord-015365-iqdi99pd 1330 5 release release NN cord-015365-iqdi99pd 1330 6 14.0 14.0 CD cord-015365-iqdi99pd 1330 7 ; ; : cord-015365-iqdi99pd 1330 8 SPSS SPSS NNP cord-015365-iqdi99pd 1330 9 , , , cord-015365-iqdi99pd 1330 10 Inc Inc NNP cord-015365-iqdi99pd 1330 11 ) ) -RRB- cord-015365-iqdi99pd 1330 12 was be VBD cord-015365-iqdi99pd 1330 13 used use VBN cord-015365-iqdi99pd 1330 14 for for IN cord-015365-iqdi99pd 1330 15 statistical statistical JJ cord-015365-iqdi99pd 1330 16 analyses analysis NNS cord-015365-iqdi99pd 1330 17 . . . cord-015365-iqdi99pd 1331 1 Continuous continuous JJ cord-015365-iqdi99pd 1331 2 variables variable NNS cord-015365-iqdi99pd 1331 3 were be VBD cord-015365-iqdi99pd 1331 4 analyzed analyze VBN cord-015365-iqdi99pd 1331 5 by by IN cord-015365-iqdi99pd 1331 6 ANOVA anova NN cord-015365-iqdi99pd 1331 7 - - HYPH cord-015365-iqdi99pd 1331 8 test test NN cord-015365-iqdi99pd 1331 9 and and CC cord-015365-iqdi99pd 1331 10 presented present VBD cord-015365-iqdi99pd 1331 11 as as IN cord-015365-iqdi99pd 1331 12 means mean VBZ cord-015365-iqdi99pd 1331 13 AE AE NNP cord-015365-iqdi99pd 1331 14 standard standard JJ cord-015365-iqdi99pd 1331 15 deviation deviation NN cord-015365-iqdi99pd 1331 16 , , , cord-015365-iqdi99pd 1331 17 variables variable NNS cord-015365-iqdi99pd 1331 18 deviating deviate VBG cord-015365-iqdi99pd 1331 19 from from IN cord-015365-iqdi99pd 1331 20 normal normal JJ cord-015365-iqdi99pd 1331 21 distribution distribution NN cord-015365-iqdi99pd 1331 22 were be VBD cord-015365-iqdi99pd 1331 23 analyzed analyze VBN cord-015365-iqdi99pd 1331 24 by by IN cord-015365-iqdi99pd 1331 25 rank rank NN cord-015365-iqdi99pd 1331 26 sum sum NN cord-015365-iqdi99pd 1331 27 test test NN cord-015365-iqdi99pd 1331 28 and and CC cord-015365-iqdi99pd 1331 29 presented present VBD cord-015365-iqdi99pd 1331 30 as as IN cord-015365-iqdi99pd 1331 31 median median NN cord-015365-iqdi99pd 1331 32 and and CC cord-015365-iqdi99pd 1331 33 range range NN cord-015365-iqdi99pd 1331 34 . . . cord-015365-iqdi99pd 1332 1 Categorical categorical JJ cord-015365-iqdi99pd 1332 2 variables variable NNS cord-015365-iqdi99pd 1332 3 are be VBP cord-015365-iqdi99pd 1332 4 presented present VBN cord-015365-iqdi99pd 1332 5 as as IN cord-015365-iqdi99pd 1332 6 percentages percentage NNS cord-015365-iqdi99pd 1332 7 and and CC cord-015365-iqdi99pd 1332 8 were be VBD cord-015365-iqdi99pd 1332 9 compared compare VBN cord-015365-iqdi99pd 1332 10 by by IN cord-015365-iqdi99pd 1332 11 chi chi JJ cord-015365-iqdi99pd 1332 12 - - JJ cord-015365-iqdi99pd 1332 13 square square JJ cord-015365-iqdi99pd 1332 14 test test NN cord-015365-iqdi99pd 1332 15 . . . cord-015365-iqdi99pd 1333 1 The the DT cord-015365-iqdi99pd 1333 2 criterion criterion NN cord-015365-iqdi99pd 1333 3 for for IN cord-015365-iqdi99pd 1333 4 statistical statistical JJ cord-015365-iqdi99pd 1333 5 significance significance NN cord-015365-iqdi99pd 1333 6 was be VBD cord-015365-iqdi99pd 1333 7 p p NN cord-015365-iqdi99pd 1333 8 < < XX cord-015365-iqdi99pd 1333 9 0.05 0.05 CD cord-015365-iqdi99pd 1333 10 . . . cord-015365-iqdi99pd 1334 1 Results result NNS cord-015365-iqdi99pd 1334 2 . . . cord-015365-iqdi99pd 1335 1 Ninety ninety CD cord-015365-iqdi99pd 1335 2 - - HYPH cord-015365-iqdi99pd 1335 3 two two CD cord-015365-iqdi99pd 1335 4 liver liver NN cord-015365-iqdi99pd 1335 5 transplant transplant NN cord-015365-iqdi99pd 1335 6 recipients recipient NNS cord-015365-iqdi99pd 1335 7 participated participate VBD cord-015365-iqdi99pd 1335 8 in in IN cord-015365-iqdi99pd 1335 9 the the DT cord-015365-iqdi99pd 1335 10 study study NN cord-015365-iqdi99pd 1335 11 . . . cord-015365-iqdi99pd 1336 1 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1336 2 genotypes genotype NNS cord-015365-iqdi99pd 1336 3 were be VBD cord-015365-iqdi99pd 1336 4 successfully successfully RB cord-015365-iqdi99pd 1336 5 determined determine VBN cord-015365-iqdi99pd 1336 6 in in IN cord-015365-iqdi99pd 1336 7 all all DT cord-015365-iqdi99pd 1336 8 subjects subject NNS cord-015365-iqdi99pd 1336 9 and and CC cord-015365-iqdi99pd 1336 10 did do VBD cord-015365-iqdi99pd 1336 11 not not RB cord-015365-iqdi99pd 1336 12 deviate deviate VB cord-015365-iqdi99pd 1336 13 from from IN cord-015365-iqdi99pd 1336 14 the the DT cord-015365-iqdi99pd 1336 15 Hardy Hardy NNP cord-015365-iqdi99pd 1336 16 - - HYPH cord-015365-iqdi99pd 1336 17 Weinberg Weinberg NNP cord-015365-iqdi99pd 1336 18 equilibirum equilibirum NN cord-015365-iqdi99pd 1336 19 . . . cord-015365-iqdi99pd 1337 1 86 86 CD cord-015365-iqdi99pd 1337 2 % % NN cord-015365-iqdi99pd 1337 3 of of IN cord-015365-iqdi99pd 1337 4 the the DT cord-015365-iqdi99pd 1337 5 patients patient NNS cord-015365-iqdi99pd 1337 6 carried carry VBD cord-015365-iqdi99pd 1337 7 the the DT cord-015365-iqdi99pd 1337 8 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1337 9 * * NFP cord-015365-iqdi99pd 1337 10 3/*3 3/*3 CD cord-015365-iqdi99pd 1337 11 genotype genotype NN cord-015365-iqdi99pd 1337 12 and and CC cord-015365-iqdi99pd 1337 13 were be VBD cord-015365-iqdi99pd 1337 14 thus thus RB cord-015365-iqdi99pd 1337 15 classified classify VBN cord-015365-iqdi99pd 1337 16 as as IN cord-015365-iqdi99pd 1337 17 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1337 18 non non NNS cord-015365-iqdi99pd 1337 19 - - NNS cord-015365-iqdi99pd 1337 20 expressors expressor NNS cord-015365-iqdi99pd 1337 21 . . . cord-015365-iqdi99pd 1338 1 14 14 CD cord-015365-iqdi99pd 1338 2 % % NN cord-015365-iqdi99pd 1338 3 carried carry VBD cord-015365-iqdi99pd 1338 4 the the DT cord-015365-iqdi99pd 1338 5 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1338 6 * * NFP cord-015365-iqdi99pd 1338 7 1/*3 1/*3 CD cord-015365-iqdi99pd 1338 8 genotype genotype NN cord-015365-iqdi99pd 1338 9 and and CC cord-015365-iqdi99pd 1338 10 were be VBD cord-015365-iqdi99pd 1338 11 classified classify VBN cord-015365-iqdi99pd 1338 12 as as IN cord-015365-iqdi99pd 1338 13 heterozygous heterozygous JJ cord-015365-iqdi99pd 1338 14 expressors expressor NNS cord-015365-iqdi99pd 1338 15 . . . cord-015365-iqdi99pd 1339 1 No no DT cord-015365-iqdi99pd 1339 2 homozygous homozygous JJ cord-015365-iqdi99pd 1339 3 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1339 4 expressor expressor NNP cord-015365-iqdi99pd 1339 5 ( ( -LRB- cord-015365-iqdi99pd 1339 6 * * NFP cord-015365-iqdi99pd 1339 7 1/*1 1/*1 CD cord-015365-iqdi99pd 1339 8 ) ) -RRB- cord-015365-iqdi99pd 1339 9 was be VBD cord-015365-iqdi99pd 1339 10 found find VBN cord-015365-iqdi99pd 1339 11 . . . cord-015365-iqdi99pd 1340 1 Neither neither CC cord-015365-iqdi99pd 1340 2 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1340 3 dose dose NN cord-015365-iqdi99pd 1340 4 nor nor CC cord-015365-iqdi99pd 1340 5 levels level NNS cord-015365-iqdi99pd 1340 6 were be VBD cord-015365-iqdi99pd 1340 7 significantly significantly RB cord-015365-iqdi99pd 1340 8 different different JJ cord-015365-iqdi99pd 1340 9 between between IN cord-015365-iqdi99pd 1340 10 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1340 11 expressors expressor NNS cord-015365-iqdi99pd 1340 12 and and CC cord-015365-iqdi99pd 1340 13 non non NNS cord-015365-iqdi99pd 1340 14 - - NNS cord-015365-iqdi99pd 1340 15 expressors expressor NNS cord-015365-iqdi99pd 1340 16 at at IN cord-015365-iqdi99pd 1340 17 any any DT cord-015365-iqdi99pd 1340 18 point point NN cord-015365-iqdi99pd 1340 19 of of IN cord-015365-iqdi99pd 1340 20 time time NN cord-015365-iqdi99pd 1340 21 Conclusions conclusion NNS cord-015365-iqdi99pd 1340 22 . . . cord-015365-iqdi99pd 1341 1 The the DT cord-015365-iqdi99pd 1341 2 pharmacokinetics pharmacokinetic NNS cord-015365-iqdi99pd 1341 3 of of IN cord-015365-iqdi99pd 1341 4 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1341 5 in in IN cord-015365-iqdi99pd 1341 6 patients patient NNS cord-015365-iqdi99pd 1341 7 after after IN cord-015365-iqdi99pd 1341 8 liver liver NN cord-015365-iqdi99pd 1341 9 transplantation transplantation NN cord-015365-iqdi99pd 1341 10 is be VBZ cord-015365-iqdi99pd 1341 11 not not RB cord-015365-iqdi99pd 1341 12 influenced influence VBN cord-015365-iqdi99pd 1341 13 by by IN cord-015365-iqdi99pd 1341 14 the the DT cord-015365-iqdi99pd 1341 15 recipient recipient NN cord-015365-iqdi99pd 1341 16 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1341 17 genotype genotype NN cord-015365-iqdi99pd 1341 18 . . . cord-015365-iqdi99pd 1342 1 It -PRON- PRP cord-015365-iqdi99pd 1342 2 is be VBZ cord-015365-iqdi99pd 1342 3 mostly mostly RB cord-015365-iqdi99pd 1342 4 the the DT cord-015365-iqdi99pd 1342 5 hepatic hepatic JJ cord-015365-iqdi99pd 1342 6 metabolism metabolism NN cord-015365-iqdi99pd 1342 7 that that WDT cord-015365-iqdi99pd 1342 8 contributes contribute VBZ cord-015365-iqdi99pd 1342 9 to to IN cord-015365-iqdi99pd 1342 10 the the DT cord-015365-iqdi99pd 1342 11 excretion excretion NN cord-015365-iqdi99pd 1342 12 of of IN cord-015365-iqdi99pd 1342 13 tacrolimus tacrolimus NN cord-015365-iqdi99pd 1342 14 . . . cord-015365-iqdi99pd 1343 1 The the DT cord-015365-iqdi99pd 1343 2 donor donor NN cord-015365-iqdi99pd 1343 3 CYP3A5 CYP3A5 NNP cord-015365-iqdi99pd 1343 4 genotype genotype NN cord-015365-iqdi99pd 1343 5 might may MD cord-015365-iqdi99pd 1343 6 be be VB cord-015365-iqdi99pd 1343 7 useful useful JJ cord-015365-iqdi99pd 1343 8 to to TO cord-015365-iqdi99pd 1343 9 predict predict VB cord-015365-iqdi99pd 1343 10 the the DT cord-015365-iqdi99pd 1343 11 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 1343 12 pharmacokinetics pharmacokinetics NNP cord-015365-iqdi99pd 1343 13 . . . cord-015365-iqdi99pd 1344 1 Background background NN cord-015365-iqdi99pd 1344 2 . . . cord-015365-iqdi99pd 1345 1 Due due IN cord-015365-iqdi99pd 1345 2 to to IN cord-015365-iqdi99pd 1345 3 predisposing predisposing JJ cord-015365-iqdi99pd 1345 4 factors factor NNS cord-015365-iqdi99pd 1345 5 like like IN cord-015365-iqdi99pd 1345 6 massive massive JJ cord-015365-iqdi99pd 1345 7 ascites ascite NNS cord-015365-iqdi99pd 1345 8 or or CC cord-015365-iqdi99pd 1345 9 kachexia kachexia NNP cord-015365-iqdi99pd 1345 10 incisional incisional NNP cord-015365-iqdi99pd 1346 1 hernias hernia NNS cord-015365-iqdi99pd 1346 2 occur occur VBP cord-015365-iqdi99pd 1346 3 in in IN cord-015365-iqdi99pd 1346 4 about about RB cord-015365-iqdi99pd 1346 5 30 30 CD cord-015365-iqdi99pd 1346 6 % % NN cord-015365-iqdi99pd 1346 7 of of IN cord-015365-iqdi99pd 1346 8 patients patient NNS cord-015365-iqdi99pd 1346 9 after after IN cord-015365-iqdi99pd 1346 10 LTX LTX NNP cord-015365-iqdi99pd 1346 11 . . . cord-015365-iqdi99pd 1347 1 Following follow VBG cord-015365-iqdi99pd 1347 2 LTX LTX NNP cord-015365-iqdi99pd 1347 3 the the DT cord-015365-iqdi99pd 1347 4 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1347 5 regimen regimen NN cord-015365-iqdi99pd 1347 6 has have VBZ cord-015365-iqdi99pd 1347 7 been be VBN cord-015365-iqdi99pd 1347 8 associated associate VBN cord-015365-iqdi99pd 1347 9 with with IN cord-015365-iqdi99pd 1347 10 the the DT cord-015365-iqdi99pd 1347 11 development development NN cord-015365-iqdi99pd 1347 12 of of IN cord-015365-iqdi99pd 1347 13 incisional incisional NNP cord-015365-iqdi99pd 1347 14 hernias hernia NNS cord-015365-iqdi99pd 1347 15 . . . cord-015365-iqdi99pd 1348 1 Appropriate appropriate JJ cord-015365-iqdi99pd 1348 2 closure closure NN cord-015365-iqdi99pd 1348 3 techniques technique NNS cord-015365-iqdi99pd 1348 4 are be VBP cord-015365-iqdi99pd 1348 5 still still RB cord-015365-iqdi99pd 1348 6 controversially controversially RB cord-015365-iqdi99pd 1348 7 discussed discuss VBN cord-015365-iqdi99pd 1348 8 . . . cord-015365-iqdi99pd 1349 1 The the DT cord-015365-iqdi99pd 1349 2 usage usage NN cord-015365-iqdi99pd 1349 3 of of IN cord-015365-iqdi99pd 1349 4 Mesh Mesh NNP cord-015365-iqdi99pd 1349 5 grafts graft NNS cord-015365-iqdi99pd 1349 6 is be VBZ cord-015365-iqdi99pd 1349 7 feasible feasible JJ cord-015365-iqdi99pd 1349 8 in in IN cord-015365-iqdi99pd 1349 9 those those DT cord-015365-iqdi99pd 1349 10 patients patient NNS cord-015365-iqdi99pd 1349 11 as as IN cord-015365-iqdi99pd 1349 12 direct direct JJ cord-015365-iqdi99pd 1349 13 closure closure NN cord-015365-iqdi99pd 1349 14 often often RB cord-015365-iqdi99pd 1349 15 results result VBZ cord-015365-iqdi99pd 1349 16 in in IN cord-015365-iqdi99pd 1349 17 hernia hernia NN cord-015365-iqdi99pd 1349 18 reccurrence reccurrence NN cord-015365-iqdi99pd 1349 19 . . . cord-015365-iqdi99pd 1350 1 Methods method NNS cord-015365-iqdi99pd 1350 2 and and CC cord-015365-iqdi99pd 1350 3 Results result NNS cord-015365-iqdi99pd 1350 4 . . . cord-015365-iqdi99pd 1351 1 We -PRON- PRP cord-015365-iqdi99pd 1351 2 would would MD cord-015365-iqdi99pd 1351 3 like like VB cord-015365-iqdi99pd 1351 4 to to TO cord-015365-iqdi99pd 1351 5 present present VB cord-015365-iqdi99pd 1351 6 a a DT cord-015365-iqdi99pd 1351 7 patient patient NN cord-015365-iqdi99pd 1351 8 who who WP cord-015365-iqdi99pd 1351 9 suffered suffer VBD cord-015365-iqdi99pd 1351 10 from from IN cord-015365-iqdi99pd 1351 11 an an DT cord-015365-iqdi99pd 1351 12 incisional incisional JJ cord-015365-iqdi99pd 1351 13 hernia hernia NN cord-015365-iqdi99pd 1351 14 6 6 CD cord-015365-iqdi99pd 1351 15 months month NNS cord-015365-iqdi99pd 1351 16 following follow VBG cord-015365-iqdi99pd 1351 17 LTX LTX NNP cord-015365-iqdi99pd 1351 18 . . . cord-015365-iqdi99pd 1352 1 The the DT cord-015365-iqdi99pd 1352 2 hernia hernia NN cord-015365-iqdi99pd 1352 3 was be VBD cord-015365-iqdi99pd 1352 4 repaired repair VBN cord-015365-iqdi99pd 1352 5 using use VBG cord-015365-iqdi99pd 1352 6 a a DT cord-015365-iqdi99pd 1352 7 Mesh Mesh NNP cord-015365-iqdi99pd 1352 8 graft graft NN cord-015365-iqdi99pd 1352 9 ( ( -LRB- cord-015365-iqdi99pd 1352 10 Permacol Permacol NNP cord-015365-iqdi99pd 1352 11 + + CC cord-015365-iqdi99pd 1352 12 ) ) -RRB- cord-015365-iqdi99pd 1352 13 which which WDT cord-015365-iqdi99pd 1352 14 was be VBD cord-015365-iqdi99pd 1352 15 placed place VBN cord-015365-iqdi99pd 1352 16 in in IN cord-015365-iqdi99pd 1352 17 a a DT cord-015365-iqdi99pd 1352 18 sublay sublay NN cord-015365-iqdi99pd 1352 19 technique technique NN cord-015365-iqdi99pd 1352 20 . . . cord-015365-iqdi99pd 1353 1 The the DT cord-015365-iqdi99pd 1353 2 patient patient NN cord-015365-iqdi99pd 1353 3 primarily primarily RB cord-015365-iqdi99pd 1353 4 recovered recover VBD cord-015365-iqdi99pd 1353 5 and and CC cord-015365-iqdi99pd 1353 6 was be VBD cord-015365-iqdi99pd 1353 7 dismissed dismiss VBN cord-015365-iqdi99pd 1353 8 on on IN cord-015365-iqdi99pd 1353 9 day day NN cord-015365-iqdi99pd 1353 10 7 7 CD cord-015365-iqdi99pd 1353 11 following follow VBG cord-015365-iqdi99pd 1353 12 hernial hernial JJ cord-015365-iqdi99pd 1353 13 repair repair NN cord-015365-iqdi99pd 1353 14 . . . cord-015365-iqdi99pd 1354 1 After after IN cord-015365-iqdi99pd 1354 2 14 14 CD cord-015365-iqdi99pd 1354 3 days day NNS cord-015365-iqdi99pd 1354 4 he -PRON- PRP cord-015365-iqdi99pd 1354 5 presented present VBD cord-015365-iqdi99pd 1354 6 with with IN cord-015365-iqdi99pd 1354 7 fever fever NN cord-015365-iqdi99pd 1354 8 and and CC cord-015365-iqdi99pd 1354 9 general general JJ cord-015365-iqdi99pd 1354 10 illness illness NN cord-015365-iqdi99pd 1354 11 . . . cord-015365-iqdi99pd 1355 1 An an DT cord-015365-iqdi99pd 1355 2 abdominal abdominal JJ cord-015365-iqdi99pd 1355 3 CT CT NNP cord-015365-iqdi99pd 1355 4 scan scan NN cord-015365-iqdi99pd 1355 5 revealed reveal VBD cord-015365-iqdi99pd 1355 6 a a DT cord-015365-iqdi99pd 1355 7 fluid fluid JJ cord-015365-iqdi99pd 1355 8 formation formation NN cord-015365-iqdi99pd 1355 9 above above IN cord-015365-iqdi99pd 1355 10 the the DT cord-015365-iqdi99pd 1355 11 Mesh Mesh NNP cord-015365-iqdi99pd 1355 12 graft graft NN cord-015365-iqdi99pd 1355 13 . . . cord-015365-iqdi99pd 1356 1 Open open JJ cord-015365-iqdi99pd 1356 2 drainage drainage NN cord-015365-iqdi99pd 1356 3 had have VBD cord-015365-iqdi99pd 1356 4 to to TO cord-015365-iqdi99pd 1356 5 be be VB cord-015365-iqdi99pd 1356 6 performed perform VBN cord-015365-iqdi99pd 1356 7 . . . cord-015365-iqdi99pd 1357 1 The the DT cord-015365-iqdi99pd 1357 2 healing healing NN cord-015365-iqdi99pd 1357 3 of of IN cord-015365-iqdi99pd 1357 4 the the DT cord-015365-iqdi99pd 1357 5 wound wound NN cord-015365-iqdi99pd 1357 6 was be VBD cord-015365-iqdi99pd 1357 7 impaired impair VBN cord-015365-iqdi99pd 1357 8 with with IN cord-015365-iqdi99pd 1357 9 the the DT cord-015365-iqdi99pd 1357 10 Permacol Permacol NNP cord-015365-iqdi99pd 1357 11 + + CC cord-015365-iqdi99pd 1357 12 graft graft NN cord-015365-iqdi99pd 1357 13 completely completely RB cord-015365-iqdi99pd 1357 14 visible visible JJ cord-015365-iqdi99pd 1357 15 in in IN cord-015365-iqdi99pd 1357 16 the the DT cord-015365-iqdi99pd 1357 17 wound wound NN cord-015365-iqdi99pd 1357 18 . . . cord-015365-iqdi99pd 1358 1 VAC VAC NNP cord-015365-iqdi99pd 1358 2 was be VBD cord-015365-iqdi99pd 1358 3 applied apply VBN cord-015365-iqdi99pd 1358 4 directly directly RB cord-015365-iqdi99pd 1358 5 on on IN cord-015365-iqdi99pd 1358 6 the the DT cord-015365-iqdi99pd 1358 7 Permacol Permacol NNP cord-015365-iqdi99pd 1358 8 + + CC cord-015365-iqdi99pd 1358 9 patch patch NN cord-015365-iqdi99pd 1358 10 . . . cord-015365-iqdi99pd 1359 1 The the DT cord-015365-iqdi99pd 1359 2 wound wound NN cord-015365-iqdi99pd 1359 3 closed close VBD cord-015365-iqdi99pd 1359 4 completely completely RB cord-015365-iqdi99pd 1359 5 without without IN cord-015365-iqdi99pd 1359 6 any any DT cord-015365-iqdi99pd 1359 7 sings sing NNS cord-015365-iqdi99pd 1359 8 of of IN cord-015365-iqdi99pd 1359 9 reinfection reinfection NN cord-015365-iqdi99pd 1359 10 or or CC cord-015365-iqdi99pd 1359 11 peritonitis peritonitis NN cord-015365-iqdi99pd 1359 12 until until IN cord-015365-iqdi99pd 1359 13 now now RB cord-015365-iqdi99pd 1359 14 . . . cord-015365-iqdi99pd 1360 1 An an DT cord-015365-iqdi99pd 1360 2 abdominal abdominal JJ cord-015365-iqdi99pd 1360 3 CT CT NNP cord-015365-iqdi99pd 1360 4 scan scan NN cord-015365-iqdi99pd 1360 5 4 4 CD cord-015365-iqdi99pd 1360 6 months month NNS cord-015365-iqdi99pd 1360 7 showed show VBD cord-015365-iqdi99pd 1360 8 no no DT cord-015365-iqdi99pd 1360 9 pathologies pathology NNS cord-015365-iqdi99pd 1360 10 . . . cord-015365-iqdi99pd 1361 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1361 2 . . . cord-015365-iqdi99pd 1362 1 The the DT cord-015365-iqdi99pd 1362 2 usage usage NN cord-015365-iqdi99pd 1362 3 of of IN cord-015365-iqdi99pd 1362 4 a a DT cord-015365-iqdi99pd 1362 5 Permacol Permacol NNP cord-015365-iqdi99pd 1362 6 + + CC cord-015365-iqdi99pd 1362 7 patch patch NN cord-015365-iqdi99pd 1362 8 seems seem VBZ cord-015365-iqdi99pd 1362 9 likely likely JJ cord-015365-iqdi99pd 1362 10 to to TO cord-015365-iqdi99pd 1362 11 repair repair VB cord-015365-iqdi99pd 1362 12 incisional incisional JJ cord-015365-iqdi99pd 1362 13 hernias hernia NNS cord-015365-iqdi99pd 1362 14 after after IN cord-015365-iqdi99pd 1362 15 LTX LTX NNP cord-015365-iqdi99pd 1362 16 whereas whereas IN cord-015365-iqdi99pd 1362 17 severe severe JJ cord-015365-iqdi99pd 1362 18 wound wound JJ cord-015365-iqdi99pd 1362 19 infections infection NNS cord-015365-iqdi99pd 1362 20 might may MD cord-015365-iqdi99pd 1362 21 occur occur VB cord-015365-iqdi99pd 1362 22 after after IN cord-015365-iqdi99pd 1362 23 the the DT cord-015365-iqdi99pd 1362 24 placement placement NN cord-015365-iqdi99pd 1362 25 of of IN cord-015365-iqdi99pd 1362 26 biological biological JJ cord-015365-iqdi99pd 1362 27 grafts graft NNS cord-015365-iqdi99pd 1362 28 due due JJ cord-015365-iqdi99pd 1362 29 to to IN cord-015365-iqdi99pd 1362 30 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1362 31 . . . cord-015365-iqdi99pd 1363 1 In in IN cord-015365-iqdi99pd 1363 2 our -PRON- PRP$ cord-015365-iqdi99pd 1363 3 patient patient NN cord-015365-iqdi99pd 1363 4 a a DT cord-015365-iqdi99pd 1363 5 VAC vac NN cord-015365-iqdi99pd 1363 6 treatment treatment NN cord-015365-iqdi99pd 1363 7 was be VBD cord-015365-iqdi99pd 1363 8 applied apply VBN cord-015365-iqdi99pd 1363 9 and and CC cord-015365-iqdi99pd 1363 10 managed manage VBD cord-015365-iqdi99pd 1363 11 the the DT cord-015365-iqdi99pd 1363 12 developed develop VBN cord-015365-iqdi99pd 1363 13 infection infection NN cord-015365-iqdi99pd 1363 14 well well RB cord-015365-iqdi99pd 1363 15 even even RB cord-015365-iqdi99pd 1363 16 if if IN cord-015365-iqdi99pd 1363 17 it -PRON- PRP cord-015365-iqdi99pd 1363 18 had have VBD cord-015365-iqdi99pd 1363 19 to to TO cord-015365-iqdi99pd 1363 20 be be VB cord-015365-iqdi99pd 1363 21 placed place VBN cord-015365-iqdi99pd 1363 22 directly directly RB cord-015365-iqdi99pd 1363 23 on on IN cord-015365-iqdi99pd 1363 24 the the DT cord-015365-iqdi99pd 1363 25 patch patch NN cord-015365-iqdi99pd 1363 26 . . . cord-015365-iqdi99pd 1364 1 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 1364 2 . . . cord-015365-iqdi99pd 1365 1 Empfänger Empfänger NNP cord-015365-iqdi99pd 1365 2 - - HYPH cord-015365-iqdi99pd 1365 3 Desensibilisierung Desensibilisierung NNP cord-015365-iqdi99pd 1365 4 mittels mittels NNP cord-015365-iqdi99pd 1365 5 Blutgruppen Blutgruppen NNP cord-015365-iqdi99pd 1365 6 - - HYPH cord-015365-iqdi99pd 1365 7 spezifischer spezifischer NNP cord-015365-iqdi99pd 1365 8 Immunadsorption Immunadsorption NNP cord-015365-iqdi99pd 1366 1 ( ( -LRB- cord-015365-iqdi99pd 1366 2 ABO ABO NNP cord-015365-iqdi99pd 1366 3 - - HYPH cord-015365-iqdi99pd 1366 4 IA IA NNP cord-015365-iqdi99pd 1366 5 ) ) -RRB- cord-015365-iqdi99pd 1367 1 ist ist NNP cord-015365-iqdi99pd 1367 2 derzeit derzeit NNP cord-015365-iqdi99pd 1367 3 das das NNP cord-015365-iqdi99pd 1367 4 Mittel Mittel NNP cord-015365-iqdi99pd 1367 5 der der NNP cord-015365-iqdi99pd 1367 6 Wahl Wahl NNP cord-015365-iqdi99pd 1367 7 , , , cord-015365-iqdi99pd 1367 8 um um UH cord-015365-iqdi99pd 1367 9 eine eine NN cord-015365-iqdi99pd 1367 10 erfolgreiche erfolgreiche JJ cord-015365-iqdi99pd 1368 1 Transplantation transplantation NN cord-015365-iqdi99pd 1368 2 über über NN cord-015365-iqdi99pd 1368 3 die die VBP cord-015365-iqdi99pd 1368 4 ABO ABO NNP cord-015365-iqdi99pd 1368 5 - - HYPH cord-015365-iqdi99pd 1368 6 Blutgruppen Blutgruppen NNP cord-015365-iqdi99pd 1368 7 - - HYPH cord-015365-iqdi99pd 1368 8 Barriere Barriere NNP cord-015365-iqdi99pd 1368 9 zu zu NNP cord-015365-iqdi99pd 1368 10 ermöglichen ermöglichen NN cord-015365-iqdi99pd 1368 11 . . . cord-015365-iqdi99pd 1369 1 Zu Zu NNP cord-015365-iqdi99pd 1369 2 diesem diesem JJ cord-015365-iqdi99pd 1369 3 Zweck Zweck NNP cord-015365-iqdi99pd 1369 4 wäre wäre NNP cord-015365-iqdi99pd 1369 5 der der NNP cord-015365-iqdi99pd 1369 6 Einsatz Einsatz NNP cord-015365-iqdi99pd 1369 7 von von NNP cord-015365-iqdi99pd 1369 8 regenerierbaren regenerierbaren NNP cord-015365-iqdi99pd 1369 9 , , , cord-015365-iqdi99pd 1369 10 nicht nicht NNP cord-015365-iqdi99pd 1369 11 - - HYPH cord-015365-iqdi99pd 1369 12 Antigen Antigen NNP cord-015365-iqdi99pd 1369 13 - - HYPH cord-015365-iqdi99pd 1369 14 spezifischen spezifischen NNP cord-015365-iqdi99pd 1369 15 ( ( -LRB- cord-015365-iqdi99pd 1369 16 semiselektiven semiselektiven NNP cord-015365-iqdi99pd 1369 17 ) ) -RRB- cord-015365-iqdi99pd 1370 1 Adsorbern Adsorbern NNP cord-015365-iqdi99pd 1370 2 ebenfalls ebenfalls NNP cord-015365-iqdi99pd 1370 3 denkbar denkbar NNP cord-015365-iqdi99pd 1370 4 , , , cord-015365-iqdi99pd 1370 5 aber aber NNP cord-015365-iqdi99pd 1370 6 die die VB cord-015365-iqdi99pd 1371 1 Effizienz Effizienz NNP cord-015365-iqdi99pd 1371 2 dieser dieser NNP cord-015365-iqdi99pd 1371 3 Immunadsorptionsmaterialien Immunadsorptionsmaterialien NNP cord-015365-iqdi99pd 1371 4 wurde wurde VBD cord-015365-iqdi99pd 1371 5 in in IN cord-015365-iqdi99pd 1371 6 diesem diesem JJ cord-015365-iqdi99pd 1371 7 Zusammenhang Zusammenhang NNP cord-015365-iqdi99pd 1371 8 noch noch NNP cord-015365-iqdi99pd 1371 9 nicht nicht NNP cord-015365-iqdi99pd 1371 10 getestet getestet NNP cord-015365-iqdi99pd 1371 11 . . . cord-015365-iqdi99pd 1372 1 Methodik Methodik NNP cord-015365-iqdi99pd 1372 2 . . . cord-015365-iqdi99pd 1373 1 Acht Acht NNP cord-015365-iqdi99pd 1373 2 mit mit NNP cord-015365-iqdi99pd 1373 3 ABO ABO NNP cord-015365-iqdi99pd 1373 4 - - HYPH cord-015365-iqdi99pd 1373 5 IA IA NNP cord-015365-iqdi99pd 1373 6 behandelte behandelte NNP cord-015365-iqdi99pd 1373 7 Transplantationskandidaten Transplantationskandidaten NNP cord-015365-iqdi99pd 1373 8 und und IN cord-015365-iqdi99pd 1373 9 39 39 CD cord-015365-iqdi99pd 1373 10 Patienten Patienten NNP cord-015365-iqdi99pd 1373 11 , , , cord-015365-iqdi99pd 1373 12 die die VBP cord-015365-iqdi99pd 1373 13 mit mit NNP cord-015365-iqdi99pd 1373 14 verschiedenen verschiedenen NNP cord-015365-iqdi99pd 1374 1 Indikationen Indikationen NNP cord-015365-iqdi99pd 1374 2 außerhalb außerhalb NN cord-015365-iqdi99pd 1374 3 der der NNP cord-015365-iqdi99pd 1374 4 ABO ABO NNP cord-015365-iqdi99pd 1374 5 - - HYPH cord-015365-iqdi99pd 1374 6 inkompatiblen inkompatiblen NNP cord-015365-iqdi99pd 1375 1 Transplantation transplantation NN cord-015365-iqdi99pd 1375 2 mit mit JJ cord-015365-iqdi99pd 1376 1 semiselektiver semiselektiver NNP cord-015365-iqdi99pd 1376 2 Immunadsorption Immunadsorption NNP cord-015365-iqdi99pd 1376 3 behandelt behandelt NNP cord-015365-iqdi99pd 1376 4 wurden wurden NNP cord-015365-iqdi99pd 1376 5 , , , cord-015365-iqdi99pd 1376 6 wurden wurden NNP cord-015365-iqdi99pd 1376 7 in in IN cord-015365-iqdi99pd 1376 8 die die JJ cord-015365-iqdi99pd 1376 9 Studie Studie NNP cord-015365-iqdi99pd 1376 10 inkludiert inkludiert JJ cord-015365-iqdi99pd 1376 11 . . . cord-015365-iqdi99pd 1377 1 Die die VB cord-015365-iqdi99pd 1377 2 semiselektive semiselektive VBZ cord-015365-iqdi99pd 1377 3 Behandlung Behandlung NNP cord-015365-iqdi99pd 1377 4 basierte basierte NNP cord-015365-iqdi99pd 1377 5 auf auf NNP cord-015365-iqdi99pd 1377 6 IA IA NNP cord-015365-iqdi99pd 1377 7 mit mit NNP cord-015365-iqdi99pd 1377 8 Protein Protein NNP cord-015365-iqdi99pd 1377 9 A A NNP cord-015365-iqdi99pd 1377 10 , , , cord-015365-iqdi99pd 1377 11 Peptid Peptid NNP cord-015365-iqdi99pd 1377 12 - - HYPH cord-015365-iqdi99pd 1377 13 Ligand Ligand NNP cord-015365-iqdi99pd 1377 14 und und IN cord-015365-iqdi99pd 1377 15 Anti anti JJ cord-015365-iqdi99pd 1377 16 - - JJ cord-015365-iqdi99pd 1377 17 human human JJ cord-015365-iqdi99pd 1377 18 Immunglobulin Immunglobulin NNP cord-015365-iqdi99pd 1377 19 Antikörpern Antikörpern NNP cord-015365-iqdi99pd 1377 20 . . . cord-015365-iqdi99pd 1378 1 Antikörper Antikörper NNP cord-015365-iqdi99pd 1378 2 - - HYPH cord-015365-iqdi99pd 1378 3 Muster Muster NNP cord-015365-iqdi99pd 1378 4 ( ( -LRB- cord-015365-iqdi99pd 1378 5 IgG IgG NNP cord-015365-iqdi99pd 1378 6 , , , cord-015365-iqdi99pd 1378 7 IgG1 IgG1 NNP cord-015365-iqdi99pd 1378 8 - - HYPH cord-015365-iqdi99pd 1378 9 4 4 CD cord-015365-iqdi99pd 1378 10 Subklassen Subklassen NNP cord-015365-iqdi99pd 1378 11 , , , cord-015365-iqdi99pd 1378 12 IgM IgM NNP cord-015365-iqdi99pd 1378 13 und und IN cord-015365-iqdi99pd 1378 14 Komplement Komplement NNP cord-015365-iqdi99pd 1378 15 - - HYPH cord-015365-iqdi99pd 1378 16 fixierende fixierende NNP cord-015365-iqdi99pd 1378 17 Reaktivitäten Reaktivitäten NNP cord-015365-iqdi99pd 1378 18 ) ) -RRB- cord-015365-iqdi99pd 1378 19 wurden wurden VBD cord-015365-iqdi99pd 1378 20 mit mit NNP cord-015365-iqdi99pd 1378 21 Durchflusszytometrie Durchflusszytometrie NNP cord-015365-iqdi99pd 1378 22 und und IN cord-015365-iqdi99pd 1378 23 konventionellen konventionellen NNP cord-015365-iqdi99pd 1379 1 Agglutinationstests Agglutinationstests NNP cord-015365-iqdi99pd 1379 2 analysiert analysiert VBP cord-015365-iqdi99pd 1379 3 . . . cord-015365-iqdi99pd 1380 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1380 2 . . . cord-015365-iqdi99pd 1381 1 Die die VB cord-015365-iqdi99pd 1381 2 sensitive sensitive JJ cord-015365-iqdi99pd 1381 3 Durchflusszytometrie Durchflusszytometrie NNP cord-015365-iqdi99pd 1381 4 - - HYPH cord-015365-iqdi99pd 1381 5 Analyse Analyse NNP cord-015365-iqdi99pd 1381 6 der der NN cord-015365-iqdi99pd 1381 7 mit mit NNP cord-015365-iqdi99pd 1381 8 ABO ABO NNP cord-015365-iqdi99pd 1381 9 - - HYPH cord-015365-iqdi99pd 1381 10 IA IA NNP cord-015365-iqdi99pd 1381 11 desensibilisierten desensibilisierten NNP cord-015365-iqdi99pd 1381 12 Transplantationskandidaten Transplantationskandidaten NNP cord-015365-iqdi99pd 1381 13 ergab ergab NN cord-015365-iqdi99pd 1382 1 eine eine NNP cord-015365-iqdi99pd 1382 2 profunde profunde NNP cord-015365-iqdi99pd 1382 3 , , , cord-015365-iqdi99pd 1382 4 aber aber NNP cord-015365-iqdi99pd 1382 5 auch auch NNP cord-015365-iqdi99pd 1382 6 oft oft NNP cord-015365-iqdi99pd 1382 7 unvollständige unvollständige NNP cord-015365-iqdi99pd 1382 8 Reduktion Reduktion NNP cord-015365-iqdi99pd 1382 9 der der NNP cord-015365-iqdi99pd 1382 10 ABO ABO NNP cord-015365-iqdi99pd 1382 11 - - HYPH cord-015365-iqdi99pd 1382 12 Blutgruppen Blutgruppen NNP cord-015365-iqdi99pd 1382 13 - - HYPH cord-015365-iqdi99pd 1382 14 spezifischen spezifischen NNS cord-015365-iqdi99pd 1382 15 Antikörper Antikörper NNP cord-015365-iqdi99pd 1382 16 ( ( -LRB- cord-015365-iqdi99pd 1382 17 anti anti JJ cord-015365-iqdi99pd 1382 18 - - JJ cord-015365-iqdi99pd 1382 19 A/ A/ NNP cord-015365-iqdi99pd 1382 20 B B NNP cord-015365-iqdi99pd 1382 21 ) ) -RRB- cord-015365-iqdi99pd 1382 22 . . . cord-015365-iqdi99pd 1383 1 Persistierende Persistierende NNP cord-015365-iqdi99pd 1383 2 Komplement Komplement NNP cord-015365-iqdi99pd 1383 3 - - HYPH cord-015365-iqdi99pd 1383 4 oder oder NNP cord-015365-iqdi99pd 1383 5 auch auch JJ cord-015365-iqdi99pd 1383 6 Nicht Nicht NNP cord-015365-iqdi99pd 1383 7 - - HYPH cord-015365-iqdi99pd 1383 8 Komplement Komplement NNP cord-015365-iqdi99pd 1383 9 - - HYPH cord-015365-iqdi99pd 1383 10 fixierende fixierende NNP cord-015365-iqdi99pd 1383 11 Reaktivitäten Reaktivitäten NNP cord-015365-iqdi99pd 1383 12 konnten konnten NNP cord-015365-iqdi99pd 1383 13 jedoch jedoch NNP cord-015365-iqdi99pd 1383 14 nicht nicht NNP cord-015365-iqdi99pd 1383 15 mit mit NNP cord-015365-iqdi99pd 1383 16 Abstoßung Abstoßung NNP cord-015365-iqdi99pd 1383 17 oder oder NNP cord-015365-iqdi99pd 1383 18 mit mit NNP cord-015365-iqdi99pd 1383 19 C4d C4d NNP cord-015365-iqdi99pd 1383 20 - - HYPH cord-015365-iqdi99pd 1383 21 Ablagerung Ablagerung NNP cord-015365-iqdi99pd 1383 22 in in IN cord-015365-iqdi99pd 1383 23 Kapillaren Kapillaren NNP cord-015365-iqdi99pd 1383 24 von von NNP cord-015365-iqdi99pd 1383 25 Protokoll Protokoll NNP cord-015365-iqdi99pd 1383 26 - - HYPH cord-015365-iqdi99pd 1383 27 Biopsien Biopsien NNP cord-015365-iqdi99pd 1383 28 assoziiert assoziiert NN cord-015365-iqdi99pd 1383 29 werden werden NNP cord-015365-iqdi99pd 1383 30 . . . cord-015365-iqdi99pd 1384 1 Beim Beim NNP cord-015365-iqdi99pd 1384 2 Vergleich Vergleich NNP cord-015365-iqdi99pd 1384 3 zwischen zwischen NNP cord-015365-iqdi99pd 1384 4 semiselektiver semiselektiver NNP cord-015365-iqdi99pd 1385 1 und und NNP cord-015365-iqdi99pd 1385 2 selektiver selektiver NNP cord-015365-iqdi99pd 1385 3 IA IA NNP cord-015365-iqdi99pd 1386 1 i -PRON- PRP cord-015365-iqdi99pd 1386 2 m be VBP cord-015365-iqdi99pd 1386 3 Rahmen Rahmen NNP cord-015365-iqdi99pd 1386 4 einer einer NNP cord-015365-iqdi99pd 1386 5 einmaligen einmaligen NNP cord-015365-iqdi99pd 1386 6 Behandlungssitzung Behandlungssitzung NNP cord-015365-iqdi99pd 1386 7 stellten stellten NNP cord-015365-iqdi99pd 1387 1 sich sich NNP cord-015365-iqdi99pd 1387 2 die die VBP cord-015365-iqdi99pd 1387 3 semiselektiven semiselektiven NNP cord-015365-iqdi99pd 1387 4 Adsorber Adsorber NNP cord-015365-iqdi99pd 1387 5 als als CD cord-015365-iqdi99pd 1387 6 effizienter effizienter NN cord-015365-iqdi99pd 1387 7 in in IN cord-015365-iqdi99pd 1387 8 der der NNP cord-015365-iqdi99pd 1387 9 Reduktion Reduktion NNP cord-015365-iqdi99pd 1387 10 von von NNP cord-015365-iqdi99pd 1387 11 anti anti NNP cord-015365-iqdi99pd 1387 12 - - NNP cord-015365-iqdi99pd 1387 13 A A NNP cord-015365-iqdi99pd 1387 14 / / SYM cord-015365-iqdi99pd 1387 15 B B NNP cord-015365-iqdi99pd 1387 16 IgG igg NN cord-015365-iqdi99pd 1387 17 heraus heraus NNP cord-015365-iqdi99pd 1388 1 ( ( -LRB- cord-015365-iqdi99pd 1388 2 Reduktion Reduktion NNP cord-015365-iqdi99pd 1388 3 der der NNP cord-015365-iqdi99pd 1388 4 Mediane Mediane NNP cord-015365-iqdi99pd 1389 1 auf auf NNP cord-015365-iqdi99pd 1389 2 28 28 CD cord-015365-iqdi99pd 1389 3 % % NN cord-015365-iqdi99pd 1389 4 der der NNP cord-015365-iqdi99pd 1389 5 Ausgangswerte Ausgangswerte NNP cord-015365-iqdi99pd 1389 6 versus versus IN cord-015365-iqdi99pd 1389 7 59 59 CD cord-015365-iqdi99pd 1389 8 % % NN cord-015365-iqdi99pd 1389 9 bei bei NNP cord-015365-iqdi99pd 1389 10 ABO ABO NNP cord-015365-iqdi99pd 1389 11 - - HYPH cord-015365-iqdi99pd 1389 12 IA IA NNP cord-015365-iqdi99pd 1389 13 , , , cord-015365-iqdi99pd 1389 14 p p NN cord-015365-iqdi99pd 1389 15 < < XX cord-015365-iqdi99pd 1389 16 0,001 0,001 CD cord-015365-iqdi99pd 1389 17 ) ) -RRB- cord-015365-iqdi99pd 1389 18 . . . cord-015365-iqdi99pd 1390 1 I -PRON- PRP cord-015365-iqdi99pd 1391 1 m m LS cord-015365-iqdi99pd 1392 1 Gegensatz Gegensatz NNP cord-015365-iqdi99pd 1392 2 dazu dazu NN cord-015365-iqdi99pd 1392 3 wurden wurden VBD cord-015365-iqdi99pd 1392 4 Blutgruppen Blutgruppen NNP cord-015365-iqdi99pd 1392 5 - - HYPH cord-015365-iqdi99pd 1392 6 spezifisches spezifisches NNP cord-015365-iqdi99pd 1392 7 IgM IgM NNP cord-015365-iqdi99pd 1392 8 ( ( -LRB- cord-015365-iqdi99pd 1392 9 74 74 CD cord-015365-iqdi99pd 1392 10 % % NN cord-015365-iqdi99pd 1392 11 versus versus IN cord-015365-iqdi99pd 1392 12 30 30 CD cord-015365-iqdi99pd 1392 13 % % NN cord-015365-iqdi99pd 1392 14 , , , cord-015365-iqdi99pd 1392 15 p p NN cord-015365-iqdi99pd 1392 16 < < XX cord-015365-iqdi99pd 1392 17 0,001 0,001 CD cord-015365-iqdi99pd 1392 18 ) ) -RRB- cord-015365-iqdi99pd 1392 19 und und RB cord-015365-iqdi99pd 1392 20 IgG3 IgG3 NNP cord-015365-iqdi99pd 1392 21 ( ( -LRB- cord-015365-iqdi99pd 1392 22 72 72 CD cord-015365-iqdi99pd 1392 23 % % NN cord-015365-iqdi99pd 1392 24 versus versus IN cord-015365-iqdi99pd 1392 25 42 42 CD cord-015365-iqdi99pd 1392 26 % % NN cord-015365-iqdi99pd 1392 27 , , , cord-015365-iqdi99pd 1392 28 p p NN cord-015365-iqdi99pd 1392 29 < < XX cord-015365-iqdi99pd 1392 30 0,05 0,05 XX cord-015365-iqdi99pd 1392 31 ) ) -RRB- cord-015365-iqdi99pd 1393 1 weniger weniger NNP cord-015365-iqdi99pd 1393 2 gut gut NNP cord-015365-iqdi99pd 1393 3 dezimiert dezimiert NNP cord-015365-iqdi99pd 1393 4 , , , cord-015365-iqdi99pd 1393 5 ohne ohne NNP cord-015365-iqdi99pd 1393 6 erkennbare erkennbare NNP cord-015365-iqdi99pd 1393 7 Unterschiede Unterschiede NNP cord-015365-iqdi99pd 1394 1 zwischen zwischen NNP cord-015365-iqdi99pd 1394 2 den den NNP cord-015365-iqdi99pd 1394 3 getesteten getesteten NNP cord-015365-iqdi99pd 1394 4 semiselektiven semiselektiven NNP cord-015365-iqdi99pd 1394 5 Adsorber Adsorber NNP cord-015365-iqdi99pd 1394 6 - - HYPH cord-015365-iqdi99pd 1394 7 Typen Typen NNP cord-015365-iqdi99pd 1394 8 . . . cord-015365-iqdi99pd 1395 1 Eine Eine NNP cord-015365-iqdi99pd 1395 2 Analyse Analyse NNP cord-015365-iqdi99pd 1395 3 nach nach FW cord-015365-iqdi99pd 1395 4 vier vier NNP cord-015365-iqdi99pd 1395 5 konsekutiven konsekutiven NNP cord-015365-iqdi99pd 1395 6 IA IA NNP cord-015365-iqdi99pd 1395 7 - - HYPH cord-015365-iqdi99pd 1395 8 Sitzungen Sitzungen NNP cord-015365-iqdi99pd 1395 9 zeigte zeigte NNP cord-015365-iqdi99pd 1395 10 , , , cord-015365-iqdi99pd 1395 11 dass dass NNP cord-015365-iqdi99pd 1395 12 die die VBP cord-015365-iqdi99pd 1395 13 unterlegene unterlegene NNP cord-015365-iqdi99pd 1395 14 Effizienz Effizienz NNP cord-015365-iqdi99pd 1395 15 nicht nicht NNP cord-015365-iqdi99pd 1395 16 durch durch NNP cord-015365-iqdi99pd 1395 17 wiederholte wiederholte NNP cord-015365-iqdi99pd 1395 18 Behandlungen Behandlungen NNP cord-015365-iqdi99pd 1395 19 wettgemacht wettgemacht FW cord-015365-iqdi99pd 1395 20 werden werden NNP cord-015365-iqdi99pd 1395 21 konnte konnte NNP cord-015365-iqdi99pd 1395 22 . . . cord-015365-iqdi99pd 1396 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 1396 2 . . . cord-015365-iqdi99pd 1397 1 Unsere unsere JJ cord-015365-iqdi99pd 1398 1 Beobachtung Beobachtung NNP cord-015365-iqdi99pd 1398 2 einer einer NNP cord-015365-iqdi99pd 1398 3 limitierten limitierten NNP cord-015365-iqdi99pd 1399 1 Adsorptionskapazität Adsorptionskapazität NNP cord-015365-iqdi99pd 1400 1 bezü bezü NNP cord-015365-iqdi99pd 1400 2 glich glich NNP cord-015365-iqdi99pd 1401 1 bestimmter bestimmter NNP cord-015365-iqdi99pd 1401 2 Blutgruppenspezifischer Blutgruppenspezifischer NNP cord-015365-iqdi99pd 1401 3 Immunglobulin-(Sub-)Klassen Immunglobulin-(Sub-)Klassen NNP cord-015365-iqdi99pd 1402 1 lässt lässt NNP cord-015365-iqdi99pd 1403 1 zu zu NNP cord-015365-iqdi99pd 1403 2 erhöhter erhöhter NNP cord-015365-iqdi99pd 1404 1 Vorsicht Vorsicht NNP cord-015365-iqdi99pd 1404 2 bei bei NNP cord-015365-iqdi99pd 1404 3 der der NNP cord-015365-iqdi99pd 1404 4 Verwendung Verwendung NNP cord-015365-iqdi99pd 1404 5 von von NNP cord-015365-iqdi99pd 1404 6 semiselektiven semiselektiven VBN cord-015365-iqdi99pd 1404 7 Immunadsorptionstechniken Immunadsorptionstechniken NNP cord-015365-iqdi99pd 1404 8 bei bei NNP cord-015365-iqdi99pd 1404 9 ABO ABO NNP cord-015365-iqdi99pd 1404 10 - - HYPH cord-015365-iqdi99pd 1404 11 inkompatibler inkompatibler NNP cord-015365-iqdi99pd 1404 12 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 1404 13 raten raten NNP cord-015365-iqdi99pd 1404 14 . . . cord-015365-iqdi99pd 1405 1 New new JJ cord-015365-iqdi99pd 1405 2 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1405 3 strategies strategy NNS cord-015365-iqdi99pd 1405 4 for for IN cord-015365-iqdi99pd 1405 5 preserving preserve VBG cord-015365-iqdi99pd 1405 6 renal renal JJ cord-015365-iqdi99pd 1405 7 function function NN cord-015365-iqdi99pd 1405 8 and and CC cord-015365-iqdi99pd 1405 9 improving improve VBG cord-015365-iqdi99pd 1405 10 outcome outcome NN cord-015365-iqdi99pd 1405 11 J. J. NNP cord-015365-iqdi99pd 1405 12 M. M. NNP cord-015365-iqdi99pd 1405 13 G. G. NNP cord-015365-iqdi99pd 1405 14 Boira Boira NNP cord-015365-iqdi99pd 1406 1 The the DT cord-015365-iqdi99pd 1406 2 prevention prevention NN cord-015365-iqdi99pd 1406 3 of of IN cord-015365-iqdi99pd 1406 4 acute acute JJ cord-015365-iqdi99pd 1406 5 rejection rejection NN cord-015365-iqdi99pd 1406 6 ( ( -LRB- cord-015365-iqdi99pd 1406 7 AR AR NNP cord-015365-iqdi99pd 1406 8 ) ) -RRB- cord-015365-iqdi99pd 1406 9 has have VBZ cord-015365-iqdi99pd 1406 10 been be VBN cord-015365-iqdi99pd 1406 11 the the DT cord-015365-iqdi99pd 1406 12 main main JJ cord-015365-iqdi99pd 1406 13 goal goal NN cord-015365-iqdi99pd 1406 14 of of IN cord-015365-iqdi99pd 1406 15 new new JJ cord-015365-iqdi99pd 1406 16 immunosuppressants immunosuppressant NNS cord-015365-iqdi99pd 1406 17 ( ( -LRB- cord-015365-iqdi99pd 1406 18 IS be VBZ cord-015365-iqdi99pd 1406 19 ) ) -RRB- cord-015365-iqdi99pd 1406 20 introduced introduce VBN cord-015365-iqdi99pd 1406 21 in in IN cord-015365-iqdi99pd 1406 22 renal renal JJ cord-015365-iqdi99pd 1406 23 transplantation transplantation NN cord-015365-iqdi99pd 1406 24 in in IN cord-015365-iqdi99pd 1406 25 the the DT cord-015365-iqdi99pd 1406 26 last last JJ cord-015365-iqdi99pd 1406 27 decades decade NNS cord-015365-iqdi99pd 1406 28 . . . cord-015365-iqdi99pd 1407 1 Nowadays nowadays RB cord-015365-iqdi99pd 1407 2 -with -with . cord-015365-iqdi99pd 1408 1 the the DT cord-015365-iqdi99pd 1408 2 use use NN cord-015365-iqdi99pd 1408 3 of of IN cord-015365-iqdi99pd 1408 4 calcineurin calcineurin NN cord-015365-iqdi99pd 1408 5 inhibitors inhibitor NNS cord-015365-iqdi99pd 1408 6 as as IN cord-015365-iqdi99pd 1408 7 mainstay mainstay NN cord-015365-iqdi99pd 1408 8 IS be VBZ cord-015365-iqdi99pd 1408 9 -the -the ADD cord-015365-iqdi99pd 1408 10 rejection rejection NN cord-015365-iqdi99pd 1408 11 rates rate NNS cord-015365-iqdi99pd 1408 12 are be VBP cord-015365-iqdi99pd 1408 13 low low JJ cord-015365-iqdi99pd 1408 14 . . . cord-015365-iqdi99pd 1409 1 However however RB cord-015365-iqdi99pd 1409 2 the the DT cord-015365-iqdi99pd 1409 3 nephrotoxicity nephrotoxicity NN cord-015365-iqdi99pd 1409 4 of of IN cord-015365-iqdi99pd 1409 5 these these DT cord-015365-iqdi99pd 1409 6 agents agent NNS cord-015365-iqdi99pd 1409 7 contribute contribute VBP cord-015365-iqdi99pd 1409 8 to to IN cord-015365-iqdi99pd 1409 9 the the DT cord-015365-iqdi99pd 1409 10 chronic chronic JJ cord-015365-iqdi99pd 1409 11 allograft allograft NN cord-015365-iqdi99pd 1409 12 injury injury NN cord-015365-iqdi99pd 1409 13 which which WDT cord-015365-iqdi99pd 1409 14 may may MD cord-015365-iqdi99pd 1409 15 result result VB cord-015365-iqdi99pd 1409 16 in in IN cord-015365-iqdi99pd 1409 17 graft graft NN cord-015365-iqdi99pd 1409 18 loss loss NN cord-015365-iqdi99pd 1409 19 in in IN cord-015365-iqdi99pd 1409 20 the the DT cord-015365-iqdi99pd 1409 21 long long JJ cord-015365-iqdi99pd 1409 22 term term NN cord-015365-iqdi99pd 1409 23 . . . cord-015365-iqdi99pd 1410 1 New New NNP cord-015365-iqdi99pd 1410 2 IS IS NNP cord-015365-iqdi99pd 1410 3 agents agent NNS cord-015365-iqdi99pd 1410 4 should should MD cord-015365-iqdi99pd 1410 5 effectively effectively RB cord-015365-iqdi99pd 1410 6 prevent prevent VB cord-015365-iqdi99pd 1410 7 AR AR NNP cord-015365-iqdi99pd 1410 8 and and CC cord-015365-iqdi99pd 1410 9 preserve preserve VB cord-015365-iqdi99pd 1410 10 renal renal JJ cord-015365-iqdi99pd 1410 11 function function NN cord-015365-iqdi99pd 1410 12 . . . cord-015365-iqdi99pd 1411 1 New new JJ cord-015365-iqdi99pd 1411 2 biologic biologic JJ cord-015365-iqdi99pd 1411 3 and and CC cord-015365-iqdi99pd 1411 4 small small JJ cord-015365-iqdi99pd 1411 5 molecule molecule NN cord-015365-iqdi99pd 1411 6 agents agent NNS cord-015365-iqdi99pd 1411 7 are be VBP cord-015365-iqdi99pd 1411 8 devoid devoid JJ cord-015365-iqdi99pd 1411 9 of of IN cord-015365-iqdi99pd 1411 10 nephrotoxicity nephrotoxicity NN cord-015365-iqdi99pd 1411 11 and and CC cord-015365-iqdi99pd 1411 12 interfere interfere VB cord-015365-iqdi99pd 1411 13 with with IN cord-015365-iqdi99pd 1411 14 crucial crucial JJ cord-015365-iqdi99pd 1411 15 mechanism mechanism NN cord-015365-iqdi99pd 1411 16 of of IN cord-015365-iqdi99pd 1411 17 allo allo NN cord-015365-iqdi99pd 1411 18 - - HYPH cord-015365-iqdi99pd 1411 19 immune immune JJ cord-015365-iqdi99pd 1411 20 response response NN cord-015365-iqdi99pd 1411 21 . . . cord-015365-iqdi99pd 1412 1 During during IN cord-015365-iqdi99pd 1412 2 the the DT cord-015365-iqdi99pd 1412 3 presentation presentation NN cord-015365-iqdi99pd 1412 4 recent recent JJ cord-015365-iqdi99pd 1412 5 data datum NNS cord-015365-iqdi99pd 1412 6 on on IN cord-015365-iqdi99pd 1412 7 new new JJ cord-015365-iqdi99pd 1412 8 agents agent NNS cord-015365-iqdi99pd 1412 9 and and CC cord-015365-iqdi99pd 1412 10 regimes regime NNS cord-015365-iqdi99pd 1412 11 under under IN cord-015365-iqdi99pd 1412 12 development development NN cord-015365-iqdi99pd 1412 13 in in IN cord-015365-iqdi99pd 1412 14 the the DT cord-015365-iqdi99pd 1412 15 prevention prevention NN cord-015365-iqdi99pd 1412 16 of of IN cord-015365-iqdi99pd 1412 17 AR AR NNP cord-015365-iqdi99pd 1412 18 will will MD cord-015365-iqdi99pd 1412 19 be be VB cord-015365-iqdi99pd 1412 20 discussed discuss VBN cord-015365-iqdi99pd 1412 21 . . . cord-015365-iqdi99pd 1413 1 Das Das NNP cord-015365-iqdi99pd 1413 2 Ziel Ziel NNP cord-015365-iqdi99pd 1413 3 ist ist NN cord-015365-iqdi99pd 1413 4 es es NNP cord-015365-iqdi99pd 1413 5 daher daher NNP cord-015365-iqdi99pd 1413 6 , , , cord-015365-iqdi99pd 1413 7 zum zum NNP cord-015365-iqdi99pd 1413 8 einen einen NNP cord-015365-iqdi99pd 1413 9 die die VB cord-015365-iqdi99pd 1413 10 Empfänger Empfänger NNP cord-015365-iqdi99pd 1413 11 T T NNP cord-015365-iqdi99pd 1413 12 - - HYPH cord-015365-iqdi99pd 1413 13 Lymphozyten Lymphozyten NNP cord-015365-iqdi99pd 1413 14 zu zu XX cord-015365-iqdi99pd 1413 15 eliminieren eliminieren NNP cord-015365-iqdi99pd 1414 1 oder oder NNP cord-015365-iqdi99pd 1414 2 zu zu NNP cord-015365-iqdi99pd 1414 3 tolerisieren tolerisieren NNP cord-015365-iqdi99pd 1414 4 und und IN cord-015365-iqdi99pd 1414 5 zum zum NNP cord-015365-iqdi99pd 1414 6 anderen anderen NNP cord-015365-iqdi99pd 1414 7 die die VBP cord-015365-iqdi99pd 1415 1 Spender Spender NNP cord-015365-iqdi99pd 1415 2 T T NNP cord-015365-iqdi99pd 1415 3 - - HYPH cord-015365-iqdi99pd 1415 4 Lymphozyten Lymphozyten NNP cord-015365-iqdi99pd 1415 5 zu zu NNP cord-015365-iqdi99pd 1415 6 tolerisieren tolerisieren NNS cord-015365-iqdi99pd 1415 7 . . . cord-015365-iqdi99pd 1416 1 Eine Eine NNP cord-015365-iqdi99pd 1416 2 Methode Methode NNP cord-015365-iqdi99pd 1416 3 , , , cord-015365-iqdi99pd 1416 4 die die VB cord-015365-iqdi99pd 1416 5 sich sich NNP cord-015365-iqdi99pd 1416 6 zur zur NNP cord-015365-iqdi99pd 1416 7 Eliminierung Eliminierung NNP cord-015365-iqdi99pd 1416 8 und und XX cord-015365-iqdi99pd 1417 1 Tolerisierung Tolerisierung NNP cord-015365-iqdi99pd 1417 2 der der NNP cord-015365-iqdi99pd 1417 3 Empfänger Empfänger NNP cord-015365-iqdi99pd 1417 4 T T NNP cord-015365-iqdi99pd 1417 5 - - HYPH cord-015365-iqdi99pd 1417 6 Lymphozyten Lymphozyten NNP cord-015365-iqdi99pd 1417 7 in in IN cord-015365-iqdi99pd 1417 8 der der NNP cord-015365-iqdi99pd 1417 9 Knochenmarktransplantation Knochenmarktransplantation NNP cord-015365-iqdi99pd 1417 10 bewährt bewährt NN cord-015365-iqdi99pd 1417 11 hat hat NN cord-015365-iqdi99pd 1417 12 , , , cord-015365-iqdi99pd 1417 13 ist ist NNP cord-015365-iqdi99pd 1417 14 , , , cord-015365-iqdi99pd 1417 15 neben neben NNP cord-015365-iqdi99pd 1417 16 der der NNP cord-015365-iqdi99pd 1417 17 medikamentösen medikamentösen NNP cord-015365-iqdi99pd 1417 18 Therapie Therapie NNP cord-015365-iqdi99pd 1417 19 , , , cord-015365-iqdi99pd 1417 20 die die VBP cord-015365-iqdi99pd 1417 21 total total JJ cord-015365-iqdi99pd 1417 22 nodale nodale JJ cord-015365-iqdi99pd 1417 23 Lymphknotenbestrahlung Lymphknotenbestrahlung NNP cord-015365-iqdi99pd 1417 24 . . . cord-015365-iqdi99pd 1418 1 Damit Damit NNP cord-015365-iqdi99pd 1418 2 können können NNP cord-015365-iqdi99pd 1418 3 Abstoßungsreaktionen Abstoßungsreaktionen NNP cord-015365-iqdi99pd 1418 4 selbst selbst NNP cord-015365-iqdi99pd 1418 5 bei bei NNP cord-015365-iqdi99pd 1418 6 HLA HLA NNP cord-015365-iqdi99pd 1418 7 - - HYPH cord-015365-iqdi99pd 1418 8 nichtidenten nichtidenten NNP cord-015365-iqdi99pd 1419 1 Knochenmarktransplantationen Knochenmarktransplantationen NNP cord-015365-iqdi99pd 1419 2 weitgehend weitgehend NNP cord-015365-iqdi99pd 1419 3 verhindert verhindert NNP cord-015365-iqdi99pd 1419 4 werden werden NNP cord-015365-iqdi99pd 1419 5 . . . cord-015365-iqdi99pd 1420 1 Zur Zur NNP cord-015365-iqdi99pd 1420 2 Behandlung Behandlung NNP cord-015365-iqdi99pd 1420 3 der der NNP cord-015365-iqdi99pd 1420 4 GvHD GvHD NNP cord-015365-iqdi99pd 1420 5 hat hat NN cord-015365-iqdi99pd 1420 6 sich sich NNP cord-015365-iqdi99pd 1420 7 in in IN cord-015365-iqdi99pd 1420 8 der der NNP cord-015365-iqdi99pd 1420 9 allogenen allogenen NNP cord-015365-iqdi99pd 1420 10 Knochenmarktransplantation Knochenmarktransplantation NNP cord-015365-iqdi99pd 1420 11 die die VBP cord-015365-iqdi99pd 1420 12 extracorporale extracorporale NN cord-015365-iqdi99pd 1420 13 Photopherese Photopherese NNP cord-015365-iqdi99pd 1420 14 ( ( -LRB- cord-015365-iqdi99pd 1420 15 ECP ECP NNP cord-015365-iqdi99pd 1420 16 ) ) -RRB- cord-015365-iqdi99pd 1420 17 bewährt bewährt NNP cord-015365-iqdi99pd 1420 18 , , , cord-015365-iqdi99pd 1420 19 die die VB cord-015365-iqdi99pd 1420 20 durch durch NNP cord-015365-iqdi99pd 1421 1 i -PRON- PRP cord-015365-iqdi99pd 1421 2 m be VBP cord-015365-iqdi99pd 1421 3 einzelnen einzelnen NNP cord-015365-iqdi99pd 1421 4 nicht nicht NNP cord-015365-iqdi99pd 1421 5 vollkommen vollkommen NNP cord-015365-iqdi99pd 1421 6 aufgeklärte aufgeklärte NNP cord-015365-iqdi99pd 1421 7 Mechanismen Mechanismen NNP cord-015365-iqdi99pd 1422 1 eine eine NNP cord-015365-iqdi99pd 1422 2 Toleranz Toleranz NNP cord-015365-iqdi99pd 1422 3 induziert induziert NN cord-015365-iqdi99pd 1422 4 und und NNP cord-015365-iqdi99pd 1422 5 somit somit NNP cord-015365-iqdi99pd 1422 6 in in IN cord-015365-iqdi99pd 1422 7 der der NN cord-015365-iqdi99pd 1422 8 Lage Lage NNP cord-015365-iqdi99pd 1422 9 ist ist NNP cord-015365-iqdi99pd 1422 10 , , , cord-015365-iqdi99pd 1422 11 die die VB cord-015365-iqdi99pd 1422 12 GvHD GvHD NNP cord-015365-iqdi99pd 1422 13 ohne ohne NNP cord-015365-iqdi99pd 1422 14 intensive intensive JJ cord-015365-iqdi99pd 1422 15 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 1422 16 zu zu NNP cord-015365-iqdi99pd 1422 17 mildern mildern NNP cord-015365-iqdi99pd 1422 18 oder oder NNP cord-015365-iqdi99pd 1422 19 auch auch NNP cord-015365-iqdi99pd 1422 20 ganz ganz NNP cord-015365-iqdi99pd 1422 21 zu zu NNP cord-015365-iqdi99pd 1422 22 eliminieren eliminieren NNP cord-015365-iqdi99pd 1422 23 . . . cord-015365-iqdi99pd 1423 1 Anhand Anhand NNP cord-015365-iqdi99pd 1423 2 von von NNP cord-015365-iqdi99pd 1423 3 Fallbeispielen Fallbeispielen NNP cord-015365-iqdi99pd 1424 1 wird wird NNP cord-015365-iqdi99pd 1424 2 diskutiert diskutiert NNP cord-015365-iqdi99pd 1424 3 werden werden NNP cord-015365-iqdi99pd 1425 1 , , , cord-015365-iqdi99pd 1425 2 dass dass NNP cord-015365-iqdi99pd 1425 3 die die VBP cord-015365-iqdi99pd 1425 4 total total JJ cord-015365-iqdi99pd 1425 5 nodale nodale NN cord-015365-iqdi99pd 1426 1 Lymphknotenbestrahlung Lymphknotenbestrahlung NNP cord-015365-iqdi99pd 1426 2 und und IN cord-015365-iqdi99pd 1426 3 ECP ECP NNP cord-015365-iqdi99pd 1426 4 auch auch NNP cord-015365-iqdi99pd 1426 5 in in IN cord-015365-iqdi99pd 1426 6 der der NNP cord-015365-iqdi99pd 1426 7 Organtransplantation Organtransplantation NNP cord-015365-iqdi99pd 1427 1 eine eine NNP cord-015365-iqdi99pd 1427 2 Rolle Rolle NNP cord-015365-iqdi99pd 1427 3 spielen spielen NNP cord-015365-iqdi99pd 1427 4 könnten könnten NNP cord-015365-iqdi99pd 1428 1 , , , cord-015365-iqdi99pd 1428 2 da da NNP cord-015365-iqdi99pd 1428 3 die die VBP cord-015365-iqdi99pd 1428 4 Mechanismen Mechanismen NNP cord-015365-iqdi99pd 1428 5 der der NNP cord-015365-iqdi99pd 1428 6 Toleranz Toleranz NNP cord-015365-iqdi99pd 1428 7 oder oder NNP cord-015365-iqdi99pd 1428 8 Abstoßung Abstoßung NNP cord-015365-iqdi99pd 1428 9 sich sich NNP cord-015365-iqdi99pd 1428 10 prinzipiell prinzipiell NNP cord-015365-iqdi99pd 1428 11 nicht nicht NNP cord-015365-iqdi99pd 1428 12 von von NNP cord-015365-iqdi99pd 1428 13 einer einer NNP cord-015365-iqdi99pd 1428 14 Knochenmarktransplantation Knochenmarktransplantation NNP cord-015365-iqdi99pd 1428 15 unterscheiden unterscheiden JJ cord-015365-iqdi99pd 1428 16 . . . cord-015365-iqdi99pd 1429 1 Plenarsitzung Plenarsitzung NNP cord-015365-iqdi99pd 1429 2 IV IV NNP cord-015365-iqdi99pd 1429 3 : : : cord-015365-iqdi99pd 1430 1 Immun Immun NNP cord-015365-iqdi99pd 1430 2 - - HYPH cord-015365-iqdi99pd 1430 3 und und NNP cord-015365-iqdi99pd 1431 1 Organtoleranz Organtoleranz NNP cord-015365-iqdi99pd 1431 2 / / SYM cord-015365-iqdi99pd 1431 3 Toleranzinduktion Toleranzinduktion NNP cord-015365-iqdi99pd 1431 4 II II NNP cord-015365-iqdi99pd 1431 5 067 067 CD cord-015365-iqdi99pd 1431 6 Approaches approach NNS cord-015365-iqdi99pd 1431 7 to to IN cord-015365-iqdi99pd 1431 8 tolerance tolerance NN cord-015365-iqdi99pd 1431 9 : : : cord-015365-iqdi99pd 1431 10 mouse mouse NN cord-015365-iqdi99pd 1431 11 to to IN cord-015365-iqdi99pd 1431 12 man man VB cord-015365-iqdi99pd 1431 13 Harvard Harvard NNP cord-015365-iqdi99pd 1431 14 Medical Medical NNP cord-015365-iqdi99pd 1431 15 School School NNP cord-015365-iqdi99pd 1431 16 , , , cord-015365-iqdi99pd 1431 17 Division Division NNP cord-015365-iqdi99pd 1431 18 of of IN cord-015365-iqdi99pd 1431 19 Transplantation Transplantation NNP cord-015365-iqdi99pd 1431 20 , , , cord-015365-iqdi99pd 1431 21 Massachusetts Massachusetts NNP cord-015365-iqdi99pd 1431 22 General General NNP cord-015365-iqdi99pd 1431 23 Hospital Hospital NNP cord-015365-iqdi99pd 1431 24 , , , cord-015365-iqdi99pd 1431 25 Boston Boston NNP cord-015365-iqdi99pd 1431 26 , , , cord-015365-iqdi99pd 1431 27 MA MA NNP cord-015365-iqdi99pd 1431 28 , , , cord-015365-iqdi99pd 1431 29 USA USA NNP cord-015365-iqdi99pd 1432 1 Over over IN cord-015365-iqdi99pd 1432 2 the the DT cord-015365-iqdi99pd 1432 3 past past JJ cord-015365-iqdi99pd 1432 4 two two CD cord-015365-iqdi99pd 1432 5 decades decade NNS cord-015365-iqdi99pd 1432 6 , , , cord-015365-iqdi99pd 1432 7 non non JJ cord-015365-iqdi99pd 1432 8 - - JJ cord-015365-iqdi99pd 1432 9 specific specific JJ cord-015365-iqdi99pd 1432 10 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1432 11 ( ( -LRB- cord-015365-iqdi99pd 1432 12 I.S. I.S. NNP cord-015365-iqdi99pd 1432 13 ) ) -RRB- cord-015365-iqdi99pd 1432 14 incorporating incorporate VBG cord-015365-iqdi99pd 1432 15 polyclonal polyclonal JJ cord-015365-iqdi99pd 1432 16 and and CC cord-015365-iqdi99pd 1432 17 monoclonal monoclonal JJ cord-015365-iqdi99pd 1432 18 antibodies antibody NNS cord-015365-iqdi99pd 1432 19 , , , cord-015365-iqdi99pd 1432 20 calcineurin calcineurin NNP cord-015365-iqdi99pd 1432 21 inhibitors inhibitor NNS cord-015365-iqdi99pd 1432 22 ( ( -LRB- cord-015365-iqdi99pd 1432 23 CNI CNI NNP cord-015365-iqdi99pd 1432 24 ) ) -RRB- cord-015365-iqdi99pd 1432 25 , , , cord-015365-iqdi99pd 1432 26 mTOR mTOR NNP cord-015365-iqdi99pd 1432 27 inhibitors inhibitor NNS cord-015365-iqdi99pd 1432 28 , , , cord-015365-iqdi99pd 1432 29 anti anti NNS cord-015365-iqdi99pd 1432 30 - - NNS cord-015365-iqdi99pd 1432 31 metabolites metabolite NNS cord-015365-iqdi99pd 1432 32 and and CC cord-015365-iqdi99pd 1432 33 steroids steroid NNS cord-015365-iqdi99pd 1432 34 have have VBP cord-015365-iqdi99pd 1432 35 greatly greatly RB cord-015365-iqdi99pd 1432 36 improved improve VBN cord-015365-iqdi99pd 1432 37 early early JJ cord-015365-iqdi99pd 1432 38 allograft allograft NN cord-015365-iqdi99pd 1432 39 survival survival NN cord-015365-iqdi99pd 1432 40 rates rate NNS cord-015365-iqdi99pd 1432 41 . . . cord-015365-iqdi99pd 1433 1 However however RB cord-015365-iqdi99pd 1433 2 , , , cord-015365-iqdi99pd 1433 3 the the DT cord-015365-iqdi99pd 1433 4 rate rate NN cord-015365-iqdi99pd 1433 5 of of IN cord-015365-iqdi99pd 1433 6 chronic chronic JJ cord-015365-iqdi99pd 1433 7 allograft allograft NN cord-015365-iqdi99pd 1433 8 loss loss NN cord-015365-iqdi99pd 1433 9 has have VBZ cord-015365-iqdi99pd 1433 10 decreased decrease VBN cord-015365-iqdi99pd 1433 11 only only RB cord-015365-iqdi99pd 1433 12 modestly modestly RB cord-015365-iqdi99pd 1433 13 over over IN cord-015365-iqdi99pd 1433 14 that that DT cord-015365-iqdi99pd 1433 15 observed observe VBD cord-015365-iqdi99pd 1433 16 earlier early RBR cord-015365-iqdi99pd 1433 17 . . . cord-015365-iqdi99pd 1434 1 Following follow VBG cord-015365-iqdi99pd 1434 2 kidney kidney NN cord-015365-iqdi99pd 1434 3 transplantation transplantation NN cord-015365-iqdi99pd 1434 4 , , , cord-015365-iqdi99pd 1434 5 for for IN cord-015365-iqdi99pd 1434 6 example example NN cord-015365-iqdi99pd 1434 7 , , , cord-015365-iqdi99pd 1434 8 the the DT cord-015365-iqdi99pd 1434 9 rate rate NN cord-015365-iqdi99pd 1434 10 of of IN cord-015365-iqdi99pd 1434 11 chronic chronic JJ cord-015365-iqdi99pd 1434 12 attrition attrition NN cord-015365-iqdi99pd 1434 13 is be VBZ cord-015365-iqdi99pd 1434 14 discouragingly discouragingly RB cord-015365-iqdi99pd 1434 15 similar similar JJ cord-015365-iqdi99pd 1434 16 to to IN cord-015365-iqdi99pd 1434 17 that that DT cord-015365-iqdi99pd 1434 18 observed observe VBD cord-015365-iqdi99pd 1434 19 two two CD cord-015365-iqdi99pd 1434 20 decades decade NNS cord-015365-iqdi99pd 1434 21 ago ago RB cord-015365-iqdi99pd 1434 22 , , , cord-015365-iqdi99pd 1434 23 generally generally RB cord-015365-iqdi99pd 1434 24 resulting result VBG cord-015365-iqdi99pd 1434 25 from from IN cord-015365-iqdi99pd 1434 26 " " `` cord-015365-iqdi99pd 1434 27 chronic chronic JJ cord-015365-iqdi99pd 1434 28 rejection rejection NN cord-015365-iqdi99pd 1434 29 " " '' cord-015365-iqdi99pd 1434 30 or or CC cord-015365-iqdi99pd 1434 31 , , , cord-015365-iqdi99pd 1434 32 perhaps perhaps RB cord-015365-iqdi99pd 1434 33 more more RBR cord-015365-iqdi99pd 1434 34 accurately accurately RB cord-015365-iqdi99pd 1434 35 , , , cord-015365-iqdi99pd 1434 36 " " `` cord-015365-iqdi99pd 1434 37 chronic chronic JJ cord-015365-iqdi99pd 1434 38 allograft allograft NN cord-015365-iqdi99pd 1434 39 nephropathy nephropathy NN cord-015365-iqdi99pd 1434 40 " " '' cord-015365-iqdi99pd 1434 41 . . . cord-015365-iqdi99pd 1435 1 The the DT cord-015365-iqdi99pd 1435 2 relentless relentless JJ cord-015365-iqdi99pd 1435 3 progression progression NN cord-015365-iqdi99pd 1435 4 of of IN cord-015365-iqdi99pd 1435 5 similar similar JJ cord-015365-iqdi99pd 1435 6 histopathologic histopathologic JJ cord-015365-iqdi99pd 1435 7 processes process NNS cord-015365-iqdi99pd 1435 8 is be VBZ cord-015365-iqdi99pd 1435 9 manifested manifest VBN cord-015365-iqdi99pd 1435 10 as as IN cord-015365-iqdi99pd 1435 11 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 1435 12 in in IN cord-015365-iqdi99pd 1435 13 the the DT cord-015365-iqdi99pd 1435 14 coronary coronary JJ cord-015365-iqdi99pd 1435 15 arteries artery NNS cord-015365-iqdi99pd 1435 16 of of IN cord-015365-iqdi99pd 1435 17 heart heart NN cord-015365-iqdi99pd 1435 18 allografts allografts NNP cord-015365-iqdi99pd 1435 19 ( ( -LRB- cord-015365-iqdi99pd 1435 20 CAV CAV NNP cord-015365-iqdi99pd 1435 21 ) ) -RRB- cord-015365-iqdi99pd 1435 22 and and CC cord-015365-iqdi99pd 1435 23 in in IN cord-015365-iqdi99pd 1435 24 lung lung NN cord-015365-iqdi99pd 1435 25 transplants transplant NNS cord-015365-iqdi99pd 1435 26 as as IN cord-015365-iqdi99pd 1435 27 obliterative obliterative JJ cord-015365-iqdi99pd 1435 28 bronchiolitis bronchiolitis NN cord-015365-iqdi99pd 1435 29 ( ( -LRB- cord-015365-iqdi99pd 1435 30 OB OB NNP cord-015365-iqdi99pd 1435 31 ) ) -RRB- cord-015365-iqdi99pd 1435 32 despite despite IN cord-015365-iqdi99pd 1435 33 the the DT cord-015365-iqdi99pd 1435 34 long long JJ cord-015365-iqdi99pd 1435 35 - - HYPH cord-015365-iqdi99pd 1435 36 term term NN cord-015365-iqdi99pd 1435 37 administration administration NN cord-015365-iqdi99pd 1435 38 of of IN cord-015365-iqdi99pd 1435 39 currently currently RB cord-015365-iqdi99pd 1435 40 available available JJ cord-015365-iqdi99pd 1436 1 I.S. I.S. NNP cord-015365-iqdi99pd 1436 2 Thus thus RB cord-015365-iqdi99pd 1436 3 , , , cord-015365-iqdi99pd 1436 4 the the DT cord-015365-iqdi99pd 1436 5 ultimate ultimate JJ cord-015365-iqdi99pd 1436 6 goal goal NN cord-015365-iqdi99pd 1436 7 of of IN cord-015365-iqdi99pd 1436 8 I.S. I.S. NNP cord-015365-iqdi99pd 1436 9 for for IN cord-015365-iqdi99pd 1436 10 transplant transplant NN cord-015365-iqdi99pd 1436 11 recipients recipient NNS cord-015365-iqdi99pd 1436 12 is be VBZ cord-015365-iqdi99pd 1436 13 the the DT cord-015365-iqdi99pd 1436 14 development development NN cord-015365-iqdi99pd 1436 15 of of IN cord-015365-iqdi99pd 1436 16 long long JJ cord-015365-iqdi99pd 1436 17 - - HYPH cord-015365-iqdi99pd 1436 18 term term NN cord-015365-iqdi99pd 1436 19 donor donor NN cord-015365-iqdi99pd 1436 20 - - HYPH cord-015365-iqdi99pd 1436 21 specific specific JJ cord-015365-iqdi99pd 1436 22 nonresponsiveness nonresponsiveness NN cord-015365-iqdi99pd 1436 23 which which WDT cord-015365-iqdi99pd 1436 24 leaves leave VBZ cord-015365-iqdi99pd 1436 25 responses response NNS cord-015365-iqdi99pd 1436 26 to to IN cord-015365-iqdi99pd 1436 27 other other JJ cord-015365-iqdi99pd 1436 28 foreign foreign JJ cord-015365-iqdi99pd 1436 29 stimuli stimulus NNS cord-015365-iqdi99pd 1436 30 intact intact JJ cord-015365-iqdi99pd 1436 31 . . . cord-015365-iqdi99pd 1437 1 Successful successful JJ cord-015365-iqdi99pd 1437 2 induction induction NN cord-015365-iqdi99pd 1437 3 of of IN cord-015365-iqdi99pd 1437 4 " " `` cord-015365-iqdi99pd 1437 5 transplant transplant NN cord-015365-iqdi99pd 1437 6 tolerance tolerance NN cord-015365-iqdi99pd 1437 7 " " '' cord-015365-iqdi99pd 1437 8 would would MD cord-015365-iqdi99pd 1437 9 avoid avoid VB cord-015365-iqdi99pd 1437 10 the the DT cord-015365-iqdi99pd 1437 11 complications complication NNS cord-015365-iqdi99pd 1437 12 of of IN cord-015365-iqdi99pd 1437 13 chronically chronically RB cord-015365-iqdi99pd 1437 14 administered administer VBN cord-015365-iqdi99pd 1437 15 I.S. I.S. NNP cord-015365-iqdi99pd 1437 16 and and CC cord-015365-iqdi99pd 1437 17 reduce reduce VB cord-015365-iqdi99pd 1437 18 the the DT cord-015365-iqdi99pd 1437 19 risks risk NNS cord-015365-iqdi99pd 1437 20 of of IN cord-015365-iqdi99pd 1437 21 chronic chronic JJ cord-015365-iqdi99pd 1437 22 rejection rejection NN cord-015365-iqdi99pd 1437 23 . . . cord-015365-iqdi99pd 1438 1 Numerous numerous JJ cord-015365-iqdi99pd 1438 2 approaches approach NNS cord-015365-iqdi99pd 1438 3 employing employ VBG cord-015365-iqdi99pd 1438 4 both both DT cord-015365-iqdi99pd 1438 5 peripheral peripheral JJ cord-015365-iqdi99pd 1438 6 and and CC cord-015365-iqdi99pd 1438 7 central central JJ cord-015365-iqdi99pd 1438 8 tolerance tolerance NN cord-015365-iqdi99pd 1438 9 mechanistic mechanistic JJ cord-015365-iqdi99pd 1438 10 strategies strategy NNS cord-015365-iqdi99pd 1438 11 have have VBP cord-015365-iqdi99pd 1438 12 been be VBN cord-015365-iqdi99pd 1438 13 successfully successfully RB cord-015365-iqdi99pd 1438 14 developed develop VBN cord-015365-iqdi99pd 1438 15 in in IN cord-015365-iqdi99pd 1438 16 rodent rodent NN cord-015365-iqdi99pd 1438 17 models model NNS cord-015365-iqdi99pd 1438 18 . . . cord-015365-iqdi99pd 1439 1 Currently currently RB cord-015365-iqdi99pd 1439 2 , , , cord-015365-iqdi99pd 1439 3 several several JJ cord-015365-iqdi99pd 1439 4 of of IN cord-015365-iqdi99pd 1439 5 these these DT cord-015365-iqdi99pd 1439 6 approaches approach NNS cord-015365-iqdi99pd 1439 7 appear appear VBP cord-015365-iqdi99pd 1439 8 to to TO cord-015365-iqdi99pd 1439 9 be be VB cord-015365-iqdi99pd 1439 10 clinically clinically RB cord-015365-iqdi99pd 1439 11 applicable applicable JJ cord-015365-iqdi99pd 1439 12 , , , cord-015365-iqdi99pd 1439 13 having have VBG cord-015365-iqdi99pd 1439 14 now now RB cord-015365-iqdi99pd 1439 15 proved prove VBN cord-015365-iqdi99pd 1439 16 to to TO cord-015365-iqdi99pd 1439 17 be be VB cord-015365-iqdi99pd 1439 18 effective effective JJ cord-015365-iqdi99pd 1439 19 in in IN cord-015365-iqdi99pd 1439 20 large large JJ cord-015365-iqdi99pd 1439 21 animal animal NN cord-015365-iqdi99pd 1439 22 models model NNS cord-015365-iqdi99pd 1439 23 and and CC cord-015365-iqdi99pd 1439 24 preliminary preliminary JJ cord-015365-iqdi99pd 1439 25 clinical clinical JJ cord-015365-iqdi99pd 1439 26 trials trial NNS cord-015365-iqdi99pd 1439 27 . . . cord-015365-iqdi99pd 1440 1 The the DT cord-015365-iqdi99pd 1440 2 most most RBS cord-015365-iqdi99pd 1440 3 successful successful JJ cord-015365-iqdi99pd 1440 4 to to IN cord-015365-iqdi99pd 1440 5 date date NN cord-015365-iqdi99pd 1440 6 has have VBZ cord-015365-iqdi99pd 1440 7 been be VBN cord-015365-iqdi99pd 1440 8 induction induction NN cord-015365-iqdi99pd 1440 9 of of IN cord-015365-iqdi99pd 1440 10 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1440 11 mixed mixed JJ cord-015365-iqdi99pd 1440 12 chimerism chimerism NN cord-015365-iqdi99pd 1440 13 . . . cord-015365-iqdi99pd 1441 1 The the DT cord-015365-iqdi99pd 1441 2 mixed mixed JJ cord-015365-iqdi99pd 1441 3 chimerism chimerism NN cord-015365-iqdi99pd 1441 4 approach approach NN cord-015365-iqdi99pd 1441 5 , , , cord-015365-iqdi99pd 1441 6 an an DT cord-015365-iqdi99pd 1441 7 initially initially RB cord-015365-iqdi99pd 1441 8 presumed presume VBN cord-015365-iqdi99pd 1441 9 central central JJ cord-015365-iqdi99pd 1441 10 tolerance tolerance NN cord-015365-iqdi99pd 1441 11 strategy strategy NN cord-015365-iqdi99pd 1441 12 , , , cord-015365-iqdi99pd 1441 13 has have VBZ cord-015365-iqdi99pd 1441 14 been be VBN cord-015365-iqdi99pd 1441 15 extensively extensively RB cord-015365-iqdi99pd 1441 16 studied study VBN cord-015365-iqdi99pd 1441 17 in in IN cord-015365-iqdi99pd 1441 18 our -PRON- PRP$ cord-015365-iqdi99pd 1441 19 laboratories laboratory NNS cord-015365-iqdi99pd 1441 20 , , , cord-015365-iqdi99pd 1441 21 first first RB cord-015365-iqdi99pd 1441 22 in in IN cord-015365-iqdi99pd 1441 23 rodent rodent NN cord-015365-iqdi99pd 1441 24 , , , cord-015365-iqdi99pd 1441 25 non non JJ cord-015365-iqdi99pd 1441 26 - - JJ cord-015365-iqdi99pd 1441 27 human human JJ cord-015365-iqdi99pd 1441 28 primate primate NN cord-015365-iqdi99pd 1441 29 , , , cord-015365-iqdi99pd 1441 30 and and CC cord-015365-iqdi99pd 1441 31 porcine porcine JJ cord-015365-iqdi99pd 1441 32 models model NNS cord-015365-iqdi99pd 1441 33 , , , cord-015365-iqdi99pd 1441 34 and and CC cord-015365-iqdi99pd 1441 35 now now RB cord-015365-iqdi99pd 1441 36 in in IN cord-015365-iqdi99pd 1441 37 human human JJ cord-015365-iqdi99pd 1441 38 recipients recipient NNS cord-015365-iqdi99pd 1441 39 of of IN cord-015365-iqdi99pd 1441 40 renal renal JJ cord-015365-iqdi99pd 1441 41 allografts allograft NNS cord-015365-iqdi99pd 1441 42 . . . cord-015365-iqdi99pd 1442 1 Using use VBG cord-015365-iqdi99pd 1442 2 a a DT cord-015365-iqdi99pd 1442 3 non non JJ cord-015365-iqdi99pd 1442 4 - - JJ cord-015365-iqdi99pd 1442 5 myeloablative myeloablative JJ cord-015365-iqdi99pd 1442 6 conditioning conditioning NN cord-015365-iqdi99pd 1442 7 regimen regimen NN cord-015365-iqdi99pd 1442 8 followed follow VBN cord-015365-iqdi99pd 1442 9 by by IN cord-015365-iqdi99pd 1442 10 donor donor NN cord-015365-iqdi99pd 1442 11 bone bone NN cord-015365-iqdi99pd 1442 12 marrow marrow NN cord-015365-iqdi99pd 1442 13 ( ( -LRB- cord-015365-iqdi99pd 1442 14 DBM DBM NNP cord-015365-iqdi99pd 1442 15 ) ) -RRB- cord-015365-iqdi99pd 1442 16 transplantation transplantation NN cord-015365-iqdi99pd 1442 17 , , , cord-015365-iqdi99pd 1442 18 we -PRON- PRP cord-015365-iqdi99pd 1442 19 observed observe VBD cord-015365-iqdi99pd 1442 20 successful successful JJ cord-015365-iqdi99pd 1442 21 production production NN cord-015365-iqdi99pd 1442 22 of of IN cord-015365-iqdi99pd 1442 23 mixed mixed JJ cord-015365-iqdi99pd 1442 24 chimerism chimerism NN cord-015365-iqdi99pd 1442 25 in in IN cord-015365-iqdi99pd 1442 26 non non JJ cord-015365-iqdi99pd 1442 27 - - JJ cord-015365-iqdi99pd 1442 28 human human JJ cord-015365-iqdi99pd 1442 29 primate primate JJ cord-015365-iqdi99pd 1442 30 renal renal JJ cord-015365-iqdi99pd 1442 31 allograft allograft NN cord-015365-iqdi99pd 1442 32 recipients recipient NNS cord-015365-iqdi99pd 1442 33 , , , cord-015365-iqdi99pd 1442 34 followed follow VBN cord-015365-iqdi99pd 1442 35 by by IN cord-015365-iqdi99pd 1442 36 normal normal JJ cord-015365-iqdi99pd 1442 37 kidney kidney NN cord-015365-iqdi99pd 1442 38 function function NN cord-015365-iqdi99pd 1442 39 with with IN cord-015365-iqdi99pd 1442 40 no no DT cord-015365-iqdi99pd 1442 41 evidence evidence NN cord-015365-iqdi99pd 1442 42 of of IN cord-015365-iqdi99pd 1442 43 chronic chronic JJ cord-015365-iqdi99pd 1442 44 rejection rejection NN cord-015365-iqdi99pd 1442 45 for for IN cord-015365-iqdi99pd 1442 46 periods period NNS cord-015365-iqdi99pd 1442 47 as as RB cord-015365-iqdi99pd 1442 48 long long JJ cord-015365-iqdi99pd 1442 49 as as IN cord-015365-iqdi99pd 1442 50 thirteen thirteen CD cord-015365-iqdi99pd 1442 51 years year NNS cord-015365-iqdi99pd 1442 52 after after IN cord-015365-iqdi99pd 1442 53 discontinuing discontinue VBG cord-015365-iqdi99pd 1442 54 all all DT cord-015365-iqdi99pd 1443 1 I.S. I.S. NNP cord-015365-iqdi99pd 1443 2 In in IN cord-015365-iqdi99pd 1443 3 vitro vitro FW cord-015365-iqdi99pd 1443 4 studies study NNS cord-015365-iqdi99pd 1443 5 of of IN cord-015365-iqdi99pd 1443 6 these these DT cord-015365-iqdi99pd 1443 7 recipients recipient NNS cord-015365-iqdi99pd 1443 8 as as RB cord-015365-iqdi99pd 1443 9 well well RB cord-015365-iqdi99pd 1443 10 as as IN cord-015365-iqdi99pd 1443 11 of of IN cord-015365-iqdi99pd 1443 12 humans human NNS cord-015365-iqdi99pd 1443 13 suggest suggest VBP cord-015365-iqdi99pd 1443 14 that that IN cord-015365-iqdi99pd 1443 15 both both DT cord-015365-iqdi99pd 1443 16 central central JJ cord-015365-iqdi99pd 1443 17 ( ( -LRB- cord-015365-iqdi99pd 1443 18 clonal clonal JJ cord-015365-iqdi99pd 1443 19 deletion deletion NN cord-015365-iqdi99pd 1443 20 ) ) -RRB- cord-015365-iqdi99pd 1443 21 and and CC cord-015365-iqdi99pd 1443 22 peripheral peripheral JJ cord-015365-iqdi99pd 1443 23 ( ( -LRB- cord-015365-iqdi99pd 1443 24 regulatory regulatory JJ cord-015365-iqdi99pd 1443 25 cells cell NNS cord-015365-iqdi99pd 1443 26 ) ) -RRB- cord-015365-iqdi99pd 1443 27 mechanisms mechanism NNS cord-015365-iqdi99pd 1443 28 are be VBP cord-015365-iqdi99pd 1443 29 involved involve VBN cord-015365-iqdi99pd 1443 30 . . . cord-015365-iqdi99pd 1444 1 Encouraged encourage VBN cord-015365-iqdi99pd 1444 2 by by IN cord-015365-iqdi99pd 1444 3 the the DT cord-015365-iqdi99pd 1444 4 pre pre JJ cord-015365-iqdi99pd 1444 5 - - JJ cord-015365-iqdi99pd 1444 6 clinical clinical JJ cord-015365-iqdi99pd 1444 7 studies study NNS cord-015365-iqdi99pd 1444 8 , , , cord-015365-iqdi99pd 1444 9 we -PRON- PRP cord-015365-iqdi99pd 1444 10 have have VBP cord-015365-iqdi99pd 1444 11 to to TO cord-015365-iqdi99pd 1444 12 date date NN cord-015365-iqdi99pd 1444 13 extended extend VBN cord-015365-iqdi99pd 1444 14 this this DT cord-015365-iqdi99pd 1444 15 approach approach NN cord-015365-iqdi99pd 1444 16 to to IN cord-015365-iqdi99pd 1444 17 20 20 CD cord-015365-iqdi99pd 1444 18 human human JJ cord-015365-iqdi99pd 1444 19 renal renal JJ cord-015365-iqdi99pd 1444 20 allograft allograft NN cord-015365-iqdi99pd 1444 21 recipients recipient NNS cord-015365-iqdi99pd 1444 22 . . . cord-015365-iqdi99pd 1445 1 Ten ten CD cord-015365-iqdi99pd 1445 2 individuals individual NNS cord-015365-iqdi99pd 1445 3 with with IN cord-015365-iqdi99pd 1445 4 ESRD ESRD NNP cord-015365-iqdi99pd 1445 5 secondary secondary JJ cord-015365-iqdi99pd 1445 6 to to IN cord-015365-iqdi99pd 1445 7 multiple multiple JJ cord-015365-iqdi99pd 1445 8 myeloma myeloma NN cord-015365-iqdi99pd 1445 9 received receive VBD cord-015365-iqdi99pd 1445 10 a a DT cord-015365-iqdi99pd 1445 11 nonmyeloablative nonmyeloablative JJ cord-015365-iqdi99pd 1445 12 preparative preparative JJ cord-015365-iqdi99pd 1445 13 regimen regimen NN cord-015365-iqdi99pd 1445 14 consisting consist VBG cord-015365-iqdi99pd 1445 15 of of IN cord-015365-iqdi99pd 1445 16 perioperative perioperative JJ cord-015365-iqdi99pd 1445 17 cyclophosphamide cyclophosphamide NN cord-015365-iqdi99pd 1445 18 , , , cord-015365-iqdi99pd 1445 19 equine equine NN cord-015365-iqdi99pd 1445 20 ATG ATG NNP cord-015365-iqdi99pd 1445 21 , , , cord-015365-iqdi99pd 1445 22 CsA csa NN cord-015365-iqdi99pd 1445 23 , , , cord-015365-iqdi99pd 1445 24 and and CC cord-015365-iqdi99pd 1445 25 thymic thymic JJ cord-015365-iqdi99pd 1445 26 irradiation irradiation NN cord-015365-iqdi99pd 1445 27 . . . cord-015365-iqdi99pd 1446 1 The the DT cord-015365-iqdi99pd 1446 2 recipients recipient NNS cord-015365-iqdi99pd 1446 3 underwent undergo VBD cord-015365-iqdi99pd 1446 4 HLA HLA NNP cord-015365-iqdi99pd 1446 5 - - HYPH cord-015365-iqdi99pd 1446 6 matched match VBN cord-015365-iqdi99pd 1446 7 kidney kidney NN cord-015365-iqdi99pd 1446 8 transplantation transplantation NN cord-015365-iqdi99pd 1446 9 followed follow VBN cord-015365-iqdi99pd 1446 10 by by IN cord-015365-iqdi99pd 1446 11 iv iv CD cord-015365-iqdi99pd 1446 12 infusion infusion NN cord-015365-iqdi99pd 1446 13 of of IN cord-015365-iqdi99pd 1446 14 DBM DBM NNP cord-015365-iqdi99pd 1446 15 and and CC cord-015365-iqdi99pd 1446 16 subsequent subsequent JJ cord-015365-iqdi99pd 1446 17 donor donor NN cord-015365-iqdi99pd 1446 18 lymphocyte lymphocyte NN cord-015365-iqdi99pd 1446 19 infusions infusion NNS cord-015365-iqdi99pd 1446 20 ( ( -LRB- cord-015365-iqdi99pd 1446 21 DLI DLI NNP cord-015365-iqdi99pd 1446 22 ) ) -RRB- cord-015365-iqdi99pd 1446 23 to to TO cord-015365-iqdi99pd 1446 24 enhance enhance VB cord-015365-iqdi99pd 1446 25 the the DT cord-015365-iqdi99pd 1446 26 anti anti JJ cord-015365-iqdi99pd 1446 27 - - JJ cord-015365-iqdi99pd 1446 28 myeloma myeloma JJ cord-015365-iqdi99pd 1446 29 effect effect NN cord-015365-iqdi99pd 1446 30 . . . cord-015365-iqdi99pd 1447 1 Transient transient JJ cord-015365-iqdi99pd 1447 2 lymphohematopoietic lymphohematopoietic JJ cord-015365-iqdi99pd 1447 3 chimerism chimerism NN cord-015365-iqdi99pd 1447 4 was be VBD cord-015365-iqdi99pd 1447 5 achieved achieve VBN cord-015365-iqdi99pd 1447 6 in in IN cord-015365-iqdi99pd 1447 7 all all DT cord-015365-iqdi99pd 1447 8 patients patient NNS cord-015365-iqdi99pd 1447 9 and and CC cord-015365-iqdi99pd 1447 10 only only RB cord-015365-iqdi99pd 1447 11 two two CD cord-015365-iqdi99pd 1447 12 reversible reversible JJ cord-015365-iqdi99pd 1447 13 rejection rejection NN cord-015365-iqdi99pd 1447 14 episodes episode NNS cord-015365-iqdi99pd 1447 15 have have VBP cord-015365-iqdi99pd 1447 16 occurred occur VBN cord-015365-iqdi99pd 1447 17 with with IN cord-015365-iqdi99pd 1447 18 a a DT cord-015365-iqdi99pd 1447 19 follow follow NN cord-015365-iqdi99pd 1447 20 - - HYPH cord-015365-iqdi99pd 1447 21 up up NN cord-015365-iqdi99pd 1447 22 of of IN cord-015365-iqdi99pd 1447 23 1 1 CD cord-015365-iqdi99pd 1447 24 to to TO cord-015365-iqdi99pd 1447 25 13 13 CD cord-015365-iqdi99pd 1447 26 years year NNS cord-015365-iqdi99pd 1447 27 after after IN cord-015365-iqdi99pd 1447 28 discontinuing discontinue VBG cord-015365-iqdi99pd 1447 29 I.S. I.S. NNP cord-015365-iqdi99pd 1447 30 Longterm Longterm NNP cord-015365-iqdi99pd 1447 31 control control NN cord-015365-iqdi99pd 1447 32 of of IN cord-015365-iqdi99pd 1447 33 the the DT cord-015365-iqdi99pd 1447 34 underlying underlying JJ cord-015365-iqdi99pd 1447 35 malignancy malignancy NN cord-015365-iqdi99pd 1447 36 was be VBD cord-015365-iqdi99pd 1447 37 better well JJR cord-015365-iqdi99pd 1447 38 than than IN cord-015365-iqdi99pd 1447 39 with with IN cord-015365-iqdi99pd 1447 40 any any DT cord-015365-iqdi99pd 1447 41 other other JJ cord-015365-iqdi99pd 1447 42 currently currently RB cord-015365-iqdi99pd 1447 43 available available JJ cord-015365-iqdi99pd 1447 44 treatment treatment NN cord-015365-iqdi99pd 1447 45 , , , cord-015365-iqdi99pd 1447 46 but but CC cord-015365-iqdi99pd 1447 47 4 4 CD cord-015365-iqdi99pd 1447 48 of of IN cord-015365-iqdi99pd 1447 49 these these DT cord-015365-iqdi99pd 1447 50 individuals individual NNS cord-015365-iqdi99pd 1447 51 required require VBD cord-015365-iqdi99pd 1447 52 additional additional JJ cord-015365-iqdi99pd 1447 53 therapy therapy NN cord-015365-iqdi99pd 1447 54 for for IN cord-015365-iqdi99pd 1447 55 recurrent recurrent JJ cord-015365-iqdi99pd 1447 56 myeloma myeloma NN cord-015365-iqdi99pd 1447 57 . . . cord-015365-iqdi99pd 1448 1 Ten ten CD cord-015365-iqdi99pd 1448 2 patients patient NNS cord-015365-iqdi99pd 1448 3 with with IN cord-015365-iqdi99pd 1448 4 ESRD ESRD NNP cord-015365-iqdi99pd 1448 5 and and CC cord-015365-iqdi99pd 1448 6 no no DT cord-015365-iqdi99pd 1448 7 myeloma myeloma NN cord-015365-iqdi99pd 1448 8 received receive VBD cord-015365-iqdi99pd 1448 9 HLA HLA NNP cord-015365-iqdi99pd 1448 10 - - HYPH cord-015365-iqdi99pd 1448 11 mismatched mismatch VBN cord-015365-iqdi99pd 1448 12 kidneys kidney NNS cord-015365-iqdi99pd 1448 13 after after IN cord-015365-iqdi99pd 1448 14 a a DT cord-015365-iqdi99pd 1448 15 similar similar JJ cord-015365-iqdi99pd 1448 16 conditioning conditioning NN cord-015365-iqdi99pd 1448 17 regimen regimen NN cord-015365-iqdi99pd 1448 18 except except IN cord-015365-iqdi99pd 1448 19 that that IN cord-015365-iqdi99pd 1448 20 MEDI-507 MEDI-507 NNP cord-015365-iqdi99pd 1448 21 , , , cord-015365-iqdi99pd 1448 22 an an DT cord-015365-iqdi99pd 1448 23 anti anti JJ cord-015365-iqdi99pd 1448 24 - - JJ cord-015365-iqdi99pd 1448 25 CD-2 CD-2 NNP cord-015365-iqdi99pd 1448 26 mAb mAb NNS cord-015365-iqdi99pd 1448 27 , , , cord-015365-iqdi99pd 1448 28 was be VBD cord-015365-iqdi99pd 1448 29 used use VBN cord-015365-iqdi99pd 1448 30 in in IN cord-015365-iqdi99pd 1448 31 place place NN cord-015365-iqdi99pd 1448 32 of of IN cord-015365-iqdi99pd 1448 33 ATG ATG NNP cord-015365-iqdi99pd 1448 34 and and CC cord-015365-iqdi99pd 1448 35 DLI DLI NNP cord-015365-iqdi99pd 1448 36 was be VBD cord-015365-iqdi99pd 1448 37 not not RB cord-015365-iqdi99pd 1448 38 used use VBN cord-015365-iqdi99pd 1448 39 . . . cord-015365-iqdi99pd 1449 1 Transient transient JJ cord-015365-iqdi99pd 1449 2 mixed mixed JJ cord-015365-iqdi99pd 1449 3 chimerism chimerism NN cord-015365-iqdi99pd 1449 4 and and CC cord-015365-iqdi99pd 1449 5 apparent apparent JJ cord-015365-iqdi99pd 1449 6 allograft allograft NN cord-015365-iqdi99pd 1449 7 tolerance tolerance NN cord-015365-iqdi99pd 1449 8 has have VBZ cord-015365-iqdi99pd 1449 9 been be VBN cord-015365-iqdi99pd 1449 10 achieved achieve VBN cord-015365-iqdi99pd 1449 11 in in IN cord-015365-iqdi99pd 1449 12 7 7 CD cord-015365-iqdi99pd 1449 13 of of IN cord-015365-iqdi99pd 1449 14 these these DT cord-015365-iqdi99pd 1449 15 recipients recipient NNS cord-015365-iqdi99pd 1449 16 . . . cord-015365-iqdi99pd 1450 1 These these DT cord-015365-iqdi99pd 1450 2 7 7 CD cord-015365-iqdi99pd 1450 3 patients patient NNS cord-015365-iqdi99pd 1450 4 have have VBP cord-015365-iqdi99pd 1450 5 received receive VBN cord-015365-iqdi99pd 1450 6 no no DT cord-015365-iqdi99pd 1450 7 I.S. I.S. NNP cord-015365-iqdi99pd 1450 8 for for IN cord-015365-iqdi99pd 1450 9 periods period NNS cord-015365-iqdi99pd 1450 10 of of IN cord-015365-iqdi99pd 1450 11 2 2 CD cord-015365-iqdi99pd 1450 12 - - SYM cord-015365-iqdi99pd 1450 13 9 9 CD cord-015365-iqdi99pd 1450 14 years year NNS cord-015365-iqdi99pd 1450 15 . . . cord-015365-iqdi99pd 1451 1 Two two CD cord-015365-iqdi99pd 1451 2 allografts allograft NNS cord-015365-iqdi99pd 1451 3 were be VBD cord-015365-iqdi99pd 1451 4 lost lose VBN cord-015365-iqdi99pd 1451 5 : : : cord-015365-iqdi99pd 1451 6 acute acute JJ cord-015365-iqdi99pd 1451 7 humoral humoral JJ cord-015365-iqdi99pd 1451 8 rejection rejection NN cord-015365-iqdi99pd 1451 9 ( ( -LRB- cord-015365-iqdi99pd 1451 10 1 1 CD cord-015365-iqdi99pd 1451 11 ) ) -RRB- cord-015365-iqdi99pd 1451 12 ; ; : cord-015365-iqdi99pd 1451 13 thrombotic thrombotic NNP cord-015365-iqdi99pd 1451 14 micro micro NNP cord-015365-iqdi99pd 1451 15 angiopathy angiopathy NNP cord-015365-iqdi99pd 1451 16 ( ( -LRB- cord-015365-iqdi99pd 1451 17 1 1 CD cord-015365-iqdi99pd 1451 18 ) ) -RRB- cord-015365-iqdi99pd 1451 19 and and CC cord-015365-iqdi99pd 1451 20 the the DT cord-015365-iqdi99pd 1451 21 last last JJ cord-015365-iqdi99pd 1451 22 recipient recipient NN cord-015365-iqdi99pd 1451 23 has have VBZ cord-015365-iqdi99pd 1451 24 been be VBN cord-015365-iqdi99pd 1451 25 returned return VBN cord-015365-iqdi99pd 1451 26 to to IN cord-015365-iqdi99pd 1451 27 chronic chronic JJ cord-015365-iqdi99pd 1451 28 I.S. I.S. NNP cord-015365-iqdi99pd 1451 29 after after IN cord-015365-iqdi99pd 1451 30 developing develop VBG cord-015365-iqdi99pd 1451 31 acute acute JJ cord-015365-iqdi99pd 1451 32 rejection rejection NN cord-015365-iqdi99pd 1451 33 when when WRB cord-015365-iqdi99pd 1451 34 I.S. I.S. NNP cord-015365-iqdi99pd 1451 35 was be VBD cord-015365-iqdi99pd 1451 36 withdrawn withdraw VBN cord-015365-iqdi99pd 1451 37 . . . cord-015365-iqdi99pd 1452 1 These these DT cord-015365-iqdi99pd 1452 2 observations observation NNS cord-015365-iqdi99pd 1452 3 plus plus CC cord-015365-iqdi99pd 1452 4 similarly similarly RB cord-015365-iqdi99pd 1452 5 encouraging encouraging JJ cord-015365-iqdi99pd 1452 6 observations observation NNS cord-015365-iqdi99pd 1452 7 in in IN cord-015365-iqdi99pd 1452 8 several several JJ cord-015365-iqdi99pd 1452 9 clinical clinical JJ cord-015365-iqdi99pd 1452 10 trials trial NNS cord-015365-iqdi99pd 1452 11 elsewhere elsewhere RB cord-015365-iqdi99pd 1452 12 suggest suggest VBP cord-015365-iqdi99pd 1452 13 that that IN cord-015365-iqdi99pd 1452 14 tolerance tolerance NN cord-015365-iqdi99pd 1452 15 induction induction NN cord-015365-iqdi99pd 1452 16 may may MD cord-015365-iqdi99pd 1452 17 become become VB cord-015365-iqdi99pd 1452 18 a a DT cord-015365-iqdi99pd 1452 19 more more RBR cord-015365-iqdi99pd 1452 20 widely widely RB cord-015365-iqdi99pd 1452 21 applicable applicable JJ cord-015365-iqdi99pd 1452 22 clinical clinical JJ cord-015365-iqdi99pd 1452 23 reality reality NN cord-015365-iqdi99pd 1452 24 . . . cord-015365-iqdi99pd 1453 1 Experimental experimental JJ cord-015365-iqdi99pd 1453 2 rationale rationale NN cord-015365-iqdi99pd 1453 3 for for IN cord-015365-iqdi99pd 1453 4 using use VBG cord-015365-iqdi99pd 1453 5 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1453 6 stem stem NN cord-015365-iqdi99pd 1453 7 cell cell NN cord-015365-iqdi99pd 1453 8 transplantation transplantation NN cord-015365-iqdi99pd 1453 9 for for IN cord-015365-iqdi99pd 1453 10 tolerance tolerance NN cord-015365-iqdi99pd 1453 11 induction induction NN cord-015365-iqdi99pd 1454 1 It -PRON- PRP cord-015365-iqdi99pd 1454 2 was be VBD cord-015365-iqdi99pd 1454 3 recognized recognize VBN cord-015365-iqdi99pd 1454 4 a a DT cord-015365-iqdi99pd 1454 5 long long JJ cord-015365-iqdi99pd 1454 6 time time NN cord-015365-iqdi99pd 1454 7 ago ago RB cord-015365-iqdi99pd 1454 8 that that IN cord-015365-iqdi99pd 1454 9 an an DT cord-015365-iqdi99pd 1454 10 individual individual NN cord-015365-iqdi99pd 1454 11 that that WDT cord-015365-iqdi99pd 1454 12 shares share NNS cord-015365-iqdi99pd 1454 13 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1454 14 cells cell NNS cord-015365-iqdi99pd 1454 15 with with IN cord-015365-iqdi99pd 1454 16 another another DT cord-015365-iqdi99pd 1454 17 , , , cord-015365-iqdi99pd 1454 18 becomes become VBZ cord-015365-iqdi99pd 1454 19 tolerant tolerant JJ cord-015365-iqdi99pd 1454 20 to to IN cord-015365-iqdi99pd 1454 21 this this DT cord-015365-iqdi99pd 1454 22 individual individual NN cord-015365-iqdi99pd 1454 23 . . . cord-015365-iqdi99pd 1455 1 Thus thus RB cord-015365-iqdi99pd 1455 2 , , , cord-015365-iqdi99pd 1455 3 a a DT cord-015365-iqdi99pd 1455 4 recipient recipient NN cord-015365-iqdi99pd 1455 5 of of IN cord-015365-iqdi99pd 1455 6 a a DT cord-015365-iqdi99pd 1455 7 successful successful JJ cord-015365-iqdi99pd 1455 8 donor donor NN cord-015365-iqdi99pd 1455 9 bone bone NN cord-015365-iqdi99pd 1455 10 marrow marrow NN cord-015365-iqdi99pd 1455 11 ( ( -LRB- cord-015365-iqdi99pd 1455 12 BM BM NNP cord-015365-iqdi99pd 1455 13 ) ) -RRB- cord-015365-iqdi99pd 1455 14 transplant transplant NN cord-015365-iqdi99pd 1455 15 ( ( -LRB- cord-015365-iqdi99pd 1455 16 BMT BMT NNP cord-015365-iqdi99pd 1455 17 ) ) -RRB- cord-015365-iqdi99pd 1455 18 becomes become VBZ cord-015365-iqdi99pd 1455 19 tolerant tolerant JJ cord-015365-iqdi99pd 1455 20 toward toward IN cord-015365-iqdi99pd 1455 21 the the DT cord-015365-iqdi99pd 1455 22 donor donor NN cord-015365-iqdi99pd 1455 23 . . . cord-015365-iqdi99pd 1456 1 Triggered trigger VBN cord-015365-iqdi99pd 1456 2 by by IN cord-015365-iqdi99pd 1456 3 this this DT cord-015365-iqdi99pd 1456 4 observation observation NN cord-015365-iqdi99pd 1456 5 experimental experimental JJ cord-015365-iqdi99pd 1456 6 studies study NNS cord-015365-iqdi99pd 1456 7 have have VBP cord-015365-iqdi99pd 1456 8 been be VBN cord-015365-iqdi99pd 1456 9 systematically systematically RB cord-015365-iqdi99pd 1456 10 addressing address VBG cord-015365-iqdi99pd 1456 11 why why WRB cord-015365-iqdi99pd 1456 12 and and CC cord-015365-iqdi99pd 1456 13 how how WRB cord-015365-iqdi99pd 1456 14 donor donor NN cord-015365-iqdi99pd 1456 15 BM bm NN cord-015365-iqdi99pd 1456 16 transplantation transplantation NN cord-015365-iqdi99pd 1456 17 achieves achieve VBZ cord-015365-iqdi99pd 1456 18 tolerance tolerance NN cord-015365-iqdi99pd 1456 19 . . . cord-015365-iqdi99pd 1457 1 The the DT cord-015365-iqdi99pd 1457 2 concept concept NN cord-015365-iqdi99pd 1457 3 of of IN cord-015365-iqdi99pd 1457 4 mixed mixed JJ cord-015365-iqdi99pd 1457 5 chimerism chimerism NN cord-015365-iqdi99pd 1457 6 -in -in : cord-015365-iqdi99pd 1457 7 which which WDT cord-015365-iqdi99pd 1457 8 a a DT cord-015365-iqdi99pd 1457 9 substantial substantial JJ cord-015365-iqdi99pd 1457 10 donor donor NN cord-015365-iqdi99pd 1457 11 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1457 12 cell cell NN cord-015365-iqdi99pd 1457 13 proportion proportion NN cord-015365-iqdi99pd 1457 14 co co NN cord-015365-iqdi99pd 1457 15 - - NN cord-015365-iqdi99pd 1457 16 exists exist VBZ cord-015365-iqdi99pd 1457 17 with with IN cord-015365-iqdi99pd 1457 18 the the DT cord-015365-iqdi99pd 1457 19 recipient recipient NN cord-015365-iqdi99pd 1457 20 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1457 21 repertoire repertoire NN cord-015365-iqdi99pd 1457 22 following follow VBG cord-015365-iqdi99pd 1457 23 donor donor NN cord-015365-iqdi99pd 1457 24 BMT BMT NNP cord-015365-iqdi99pd 1457 25 -has -has : cord-015365-iqdi99pd 1457 26 emerged emerge VBD cord-015365-iqdi99pd 1457 27 as as IN cord-015365-iqdi99pd 1457 28 a a DT cord-015365-iqdi99pd 1457 29 promising promising JJ cord-015365-iqdi99pd 1457 30 BMT BMT NNP cord-015365-iqdi99pd 1457 31 - - HYPH cord-015365-iqdi99pd 1457 32 based base VBN cord-015365-iqdi99pd 1457 33 tolerance tolerance NN cord-015365-iqdi99pd 1457 34 strategy strategy NN cord-015365-iqdi99pd 1457 35 . . . cord-015365-iqdi99pd 1458 1 Mixed mixed JJ cord-015365-iqdi99pd 1458 2 chimerism chimerism NN cord-015365-iqdi99pd 1458 3 leads lead VBZ cord-015365-iqdi99pd 1458 4 to to IN cord-015365-iqdi99pd 1458 5 a a DT cord-015365-iqdi99pd 1458 6 particularly particularly RB cord-015365-iqdi99pd 1458 7 robust robust JJ cord-015365-iqdi99pd 1458 8 and and CC cord-015365-iqdi99pd 1458 9 durable durable JJ cord-015365-iqdi99pd 1458 10 type type NN cord-015365-iqdi99pd 1458 11 of of IN cord-015365-iqdi99pd 1458 12 tolerance tolerance NN cord-015365-iqdi99pd 1458 13 . . . cord-015365-iqdi99pd 1459 1 Central central JJ cord-015365-iqdi99pd 1459 2 clonal clonal JJ cord-015365-iqdi99pd 1459 3 deletion deletion NN cord-015365-iqdi99pd 1459 4 of of IN cord-015365-iqdi99pd 1459 5 immature immature JJ cord-015365-iqdi99pd 1459 6 donorreactive donorreactive NN cord-015365-iqdi99pd 1459 7 T t NN cord-015365-iqdi99pd 1459 8 cells cell NNS cord-015365-iqdi99pd 1459 9 was be VBD cord-015365-iqdi99pd 1459 10 identified identify VBN cord-015365-iqdi99pd 1459 11 as as IN cord-015365-iqdi99pd 1459 12 a a DT cord-015365-iqdi99pd 1459 13 key key JJ cord-015365-iqdi99pd 1459 14 mechanism mechanism NN cord-015365-iqdi99pd 1459 15 of of IN cord-015365-iqdi99pd 1459 16 tolerance tolerance NN cord-015365-iqdi99pd 1459 17 in in IN cord-015365-iqdi99pd 1459 18 mixed mixed JJ cord-015365-iqdi99pd 1459 19 chimeras chimera NNS cord-015365-iqdi99pd 1459 20 and and CC cord-015365-iqdi99pd 1459 21 seems seem VBZ cord-015365-iqdi99pd 1459 22 to to TO cord-015365-iqdi99pd 1459 23 be be VB cord-015365-iqdi99pd 1459 24 in in IN cord-015365-iqdi99pd 1459 25 large large JJ cord-015365-iqdi99pd 1459 26 part part NN cord-015365-iqdi99pd 1459 27 responsible responsible JJ cord-015365-iqdi99pd 1459 28 for for IN cord-015365-iqdi99pd 1459 29 the the DT cord-015365-iqdi99pd 1459 30 robust robust JJ cord-015365-iqdi99pd 1459 31 nature nature NN cord-015365-iqdi99pd 1459 32 of of IN cord-015365-iqdi99pd 1459 33 tolerance tolerance NN cord-015365-iqdi99pd 1459 34 achieved achieve VBN cord-015365-iqdi99pd 1459 35 . . . cord-015365-iqdi99pd 1460 1 Peripheral peripheral JJ cord-015365-iqdi99pd 1460 2 clonal clonal JJ cord-015365-iqdi99pd 1460 3 deletion deletion NN cord-015365-iqdi99pd 1460 4 of of IN cord-015365-iqdi99pd 1460 5 mature mature JJ cord-015365-iqdi99pd 1460 6 donor donor NN cord-015365-iqdi99pd 1460 7 - - HYPH cord-015365-iqdi99pd 1460 8 reactive reactive JJ cord-015365-iqdi99pd 1460 9 T t NN cord-015365-iqdi99pd 1460 10 cells cell NNS cord-015365-iqdi99pd 1460 11 and and CC cord-015365-iqdi99pd 1460 12 non non JJ cord-015365-iqdi99pd 1460 13 - - JJ cord-015365-iqdi99pd 1460 14 deletional deletional JJ cord-015365-iqdi99pd 1460 15 ( ( -LRB- cord-015365-iqdi99pd 1460 16 i.e. i.e. FW cord-015365-iqdi99pd 1460 17 regulatory regulatory JJ cord-015365-iqdi99pd 1460 18 ) ) -RRB- cord-015365-iqdi99pd 1460 19 mechanisms mechanism NNS cord-015365-iqdi99pd 1460 20 also also RB cord-015365-iqdi99pd 1460 21 contribute contribute VBP cord-015365-iqdi99pd 1460 22 to to IN cord-015365-iqdi99pd 1460 23 tolerance tolerance NN cord-015365-iqdi99pd 1460 24 induction induction NN cord-015365-iqdi99pd 1460 25 in in IN cord-015365-iqdi99pd 1460 26 some some DT cord-015365-iqdi99pd 1460 27 models model NNS cord-015365-iqdi99pd 1460 28 . . . cord-015365-iqdi99pd 1461 1 Overall overall RB cord-015365-iqdi99pd 1461 2 , , , cord-015365-iqdi99pd 1461 3 donor donor NN cord-015365-iqdi99pd 1461 4 BMT BMT NNP cord-015365-iqdi99pd 1461 5 emulates emulate VBZ cord-015365-iqdi99pd 1461 6 many many JJ cord-015365-iqdi99pd 1461 7 of of IN cord-015365-iqdi99pd 1461 8 the the DT cord-015365-iqdi99pd 1461 9 physiologic physiologic JJ cord-015365-iqdi99pd 1461 10 mechanisms mechanism NNS cord-015365-iqdi99pd 1461 11 controlling control VBG cord-015365-iqdi99pd 1461 12 self self NN cord-015365-iqdi99pd 1461 13 - - HYPH cord-015365-iqdi99pd 1461 14 tolerance tolerance NN cord-015365-iqdi99pd 1461 15 , , , cord-015365-iqdi99pd 1461 16 extending extend VBG cord-015365-iqdi99pd 1461 17 them -PRON- PRP cord-015365-iqdi99pd 1461 18 to to IN cord-015365-iqdi99pd 1461 19 donor donor NN cord-015365-iqdi99pd 1461 20 antigens antigen NNS cord-015365-iqdi99pd 1461 21 . . . cord-015365-iqdi99pd 1462 1 While while IN cord-015365-iqdi99pd 1462 2 clinical clinical JJ cord-015365-iqdi99pd 1462 3 translation translation NN cord-015365-iqdi99pd 1462 4 of of IN cord-015365-iqdi99pd 1462 5 the the DT cord-015365-iqdi99pd 1462 6 mixed mixed JJ cord-015365-iqdi99pd 1462 7 chimerism chimerism NN cord-015365-iqdi99pd 1462 8 approach approach NN cord-015365-iqdi99pd 1462 9 has have VBZ cord-015365-iqdi99pd 1462 10 been be VBN cord-015365-iqdi99pd 1462 11 achieved achieve VBN cord-015365-iqdi99pd 1462 12 in in IN cord-015365-iqdi99pd 1462 13 pilot pilot NN cord-015365-iqdi99pd 1462 14 trials trial NNS cord-015365-iqdi99pd 1462 15 , , , cord-015365-iqdi99pd 1462 16 large large JJ cord-015365-iqdi99pd 1462 17 - - HYPH cord-015365-iqdi99pd 1462 18 scale scale NN cord-015365-iqdi99pd 1462 19 application application NN cord-015365-iqdi99pd 1462 20 in in IN cord-015365-iqdi99pd 1462 21 routine routine JJ cord-015365-iqdi99pd 1462 22 clinical clinical JJ cord-015365-iqdi99pd 1462 23 practice practice NN cord-015365-iqdi99pd 1462 24 awaits await VBZ cord-015365-iqdi99pd 1462 25 minimally minimally RB cord-015365-iqdi99pd 1462 26 toxic toxic JJ cord-015365-iqdi99pd 1462 27 BMT BMT NNP cord-015365-iqdi99pd 1462 28 regimens regimen NNS cord-015365-iqdi99pd 1462 29 . . . cord-015365-iqdi99pd 1463 1 Myelosuppressive myelosuppressive JJ cord-015365-iqdi99pd 1463 2 and and CC cord-015365-iqdi99pd 1463 3 cytotoxic cytotoxic JJ cord-015365-iqdi99pd 1463 4 pre pre NNS cord-015365-iqdi99pd 1463 5 - - NNS cord-015365-iqdi99pd 1463 6 treatments treatment NNS cord-015365-iqdi99pd 1463 7 commonly commonly RB cord-015365-iqdi99pd 1463 8 employed employ VBN cord-015365-iqdi99pd 1463 9 in in IN cord-015365-iqdi99pd 1463 10 ' ' `` cord-015365-iqdi99pd 1463 11 conventional conventional JJ cord-015365-iqdi99pd 1463 12 ' ' '' cord-015365-iqdi99pd 1463 13 BMT BMT NNP cord-015365-iqdi99pd 1463 14 recipients recipient NNS cord-015365-iqdi99pd 1463 15 would would MD cord-015365-iqdi99pd 1463 16 be be VB cord-015365-iqdi99pd 1463 17 unacceptable unacceptable JJ cord-015365-iqdi99pd 1463 18 in in IN cord-015365-iqdi99pd 1463 19 organ organ NN cord-015365-iqdi99pd 1463 20 transplant transplant NN cord-015365-iqdi99pd 1463 21 recipients recipient NNS cord-015365-iqdi99pd 1463 22 . . . cord-015365-iqdi99pd 1464 1 Therefore therefore RB cord-015365-iqdi99pd 1464 2 , , , cord-015365-iqdi99pd 1464 3 efforts effort NNS cord-015365-iqdi99pd 1464 4 to to TO cord-015365-iqdi99pd 1464 5 develop develop VB cord-015365-iqdi99pd 1464 6 advanced advanced JJ cord-015365-iqdi99pd 1464 7 , , , cord-015365-iqdi99pd 1464 8 non non JJ cord-015365-iqdi99pd 1464 9 - - JJ cord-015365-iqdi99pd 1464 10 toxic toxic JJ cord-015365-iqdi99pd 1464 11 murine murine NN cord-015365-iqdi99pd 1464 12 BMT BMT NNP cord-015365-iqdi99pd 1464 13 protocols protocol NNS cord-015365-iqdi99pd 1464 14 are be VBP cord-015365-iqdi99pd 1464 15 ongoing ongoing JJ cord-015365-iqdi99pd 1464 16 . . . cord-015365-iqdi99pd 1465 1 The the DT cord-015365-iqdi99pd 1465 2 use use NN cord-015365-iqdi99pd 1465 3 of of IN cord-015365-iqdi99pd 1465 4 costimulation costimulation NN cord-015365-iqdi99pd 1465 5 blockers blocker NNS cord-015365-iqdi99pd 1465 6 and and CC cord-015365-iqdi99pd 1465 7 , , , cord-015365-iqdi99pd 1465 8 more more RBR cord-015365-iqdi99pd 1465 9 recently recently RB cord-015365-iqdi99pd 1465 10 , , , cord-015365-iqdi99pd 1465 11 adjunctive adjunctive JJ cord-015365-iqdi99pd 1465 12 T T NNP cord-015365-iqdi99pd 1465 13 regulatory regulatory JJ cord-015365-iqdi99pd 1465 14 cell cell NN cord-015365-iqdi99pd 1465 15 therapy therapy NN cord-015365-iqdi99pd 1465 16 have have VBP cord-015365-iqdi99pd 1465 17 yielded yield VBN cord-015365-iqdi99pd 1465 18 dramatically dramatically RB cord-015365-iqdi99pd 1465 19 less less RBR cord-015365-iqdi99pd 1465 20 toxic toxic JJ cord-015365-iqdi99pd 1465 21 regimens regimen NNS cord-015365-iqdi99pd 1465 22 which which WDT cord-015365-iqdi99pd 1465 23 hold hold VBP cord-015365-iqdi99pd 1465 24 promise promise NN cord-015365-iqdi99pd 1465 25 for for IN cord-015365-iqdi99pd 1465 26 clinical clinical JJ cord-015365-iqdi99pd 1465 27 translation translation NN cord-015365-iqdi99pd 1465 28 . . . cord-015365-iqdi99pd 1466 1 Aspergillus aspergillus NN cord-015365-iqdi99pd 1466 2 und und IN cord-015365-iqdi99pd 1466 3 seltene seltene NNP cord-015365-iqdi99pd 1466 4 Schimmelpilzinfektionen Schimmelpilzinfektionen NNP cord-015365-iqdi99pd 1466 5 . . . cord-015365-iqdi99pd 1467 1 Die die VB cord-015365-iqdi99pd 1467 2 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 1467 3 der der NNP cord-015365-iqdi99pd 1467 4 Aspergillose Aspergillose NNP cord-015365-iqdi99pd 1467 5 bei bei NNP cord-015365-iqdi99pd 1467 6 der der NNP cord-015365-iqdi99pd 1467 7 allogenen allogenen NN cord-015365-iqdi99pd 1467 8 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 1467 9 beträgt beträgt NNP cord-015365-iqdi99pd 1467 10 zwischen zwischen NNP cord-015365-iqdi99pd 1467 11 8 8 CD cord-015365-iqdi99pd 1467 12 - - SYM cord-015365-iqdi99pd 1467 13 25 25 CD cord-015365-iqdi99pd 1467 14 % % NN cord-015365-iqdi99pd 1467 15 . . . cord-015365-iqdi99pd 1468 1 Aspergillussporen Aspergillussporen NNP cord-015365-iqdi99pd 1468 2 kommen kommen NNP cord-015365-iqdi99pd 1468 3 ubiquitär ubiquitär VBP cord-015365-iqdi99pd 1468 4 in in IN cord-015365-iqdi99pd 1468 5 der der NNP cord-015365-iqdi99pd 1468 6 Umwelt Umwelt NNP cord-015365-iqdi99pd 1468 7 vor vor NNP cord-015365-iqdi99pd 1468 8 ; ; : cord-015365-iqdi99pd 1468 9 ungefilterte ungefilterte NNP cord-015365-iqdi99pd 1468 10 Luft Luft NNP cord-015365-iqdi99pd 1468 11 aus aus NNP cord-015365-iqdi99pd 1468 12 Belü Belü NNP cord-015365-iqdi99pd 1468 13 ftungssystemen ftungssystemen NNP cord-015365-iqdi99pd 1468 14 und und IN cord-015365-iqdi99pd 1468 15 Staub Staub NNP cord-015365-iqdi99pd 1468 16 bilden bilden NNP cord-015365-iqdi99pd 1468 17 die die VB cord-015365-iqdi99pd 1468 18 Hauptinfektionsquellen Hauptinfektionsquellen NNP cord-015365-iqdi99pd 1468 19 . . . cord-015365-iqdi99pd 1469 1 Aspergillussporen Aspergillussporen NNP cord-015365-iqdi99pd 1469 2 werden werden NNP cord-015365-iqdi99pd 1470 1 exogen exogen NNP cord-015365-iqdi99pd 1470 2 durch durch NNP cord-015365-iqdi99pd 1470 3 Inhalation Inhalation NNP cord-015365-iqdi99pd 1470 4 erworben erworben NN cord-015365-iqdi99pd 1470 5 . . . cord-015365-iqdi99pd 1471 1 Die die VB cord-015365-iqdi99pd 1471 2 Reduktion Reduktion NNP cord-015365-iqdi99pd 1471 3 der der NNP cord-015365-iqdi99pd 1471 4 Sporenlast Sporenlast NNP cord-015365-iqdi99pd 1471 5 in in IN cord-015365-iqdi99pd 1471 6 der der NNP cord-015365-iqdi99pd 1471 7 Umgebung Umgebung NNP cord-015365-iqdi99pd 1471 8 von von NNP cord-015365-iqdi99pd 1471 9 Patienten Patienten NNP cord-015365-iqdi99pd 1471 10 " " '' cord-015365-iqdi99pd 1471 11 at at IN cord-015365-iqdi99pd 1471 12 risk risk NN cord-015365-iqdi99pd 1471 13 " " `` cord-015365-iqdi99pd 1471 14 ist ist FW cord-015365-iqdi99pd 1471 15 die die VB cord-015365-iqdi99pd 1471 16 wichtigste wichtigste NN cord-015365-iqdi99pd 1471 17 prophylaktische prophylaktische NN cord-015365-iqdi99pd 1471 18 Maßnahme Maßnahme NNP cord-015365-iqdi99pd 1471 19 . . . cord-015365-iqdi99pd 1472 1 Der Der NNP cord-015365-iqdi99pd 1472 2 klinisch klinisch NNP cord-015365-iqdi99pd 1472 3 wichtigste wichtigste NN cord-015365-iqdi99pd 1472 4 Vertreter Vertreter NNP cord-015365-iqdi99pd 1472 5 ist ist NN cord-015365-iqdi99pd 1472 6 Aspergillus aspergillus NN cord-015365-iqdi99pd 1472 7 fumigatus fumigatus NN cord-015365-iqdi99pd 1472 8 . . . cord-015365-iqdi99pd 1473 1 Die die VB cord-015365-iqdi99pd 1473 2 Letalität Letalität NNP cord-015365-iqdi99pd 1473 3 invasiver invasiver RB cord-015365-iqdi99pd 1474 1 Aspergillosen Aspergillosen NNP cord-015365-iqdi99pd 1474 2 liegt liegt NNP cord-015365-iqdi99pd 1474 3 bei bei NNP cord-015365-iqdi99pd 1474 4 70 70 CD cord-015365-iqdi99pd 1474 5 - - SYM cord-015365-iqdi99pd 1474 6 90 90 CD cord-015365-iqdi99pd 1474 7 % % NN cord-015365-iqdi99pd 1474 8 . . . cord-015365-iqdi99pd 1475 1 Zu Zu NNP cord-015365-iqdi99pd 1475 2 den den NNP cord-015365-iqdi99pd 1475 3 anderen anderen NNP cord-015365-iqdi99pd 1476 1 Schimmelpilzinfektionen Schimmelpilzinfektionen NNP cord-015365-iqdi99pd 1476 2 zählen zählen NNP cord-015365-iqdi99pd 1476 3 die die VBP cord-015365-iqdi99pd 1476 4 Zygomykosen Zygomykosen NNP cord-015365-iqdi99pd 1476 5 ( ( -LRB- cord-015365-iqdi99pd 1476 6 Absidia- Absidia- NNP cord-015365-iqdi99pd 1476 7 , , , cord-015365-iqdi99pd 1476 8 Mucor Mucor NNP cord-015365-iqdi99pd 1476 9 - - HYPH cord-015365-iqdi99pd 1476 10 und und NNP cord-015365-iqdi99pd 1476 11 Rhizopus Rhizopus NNP cord-015365-iqdi99pd 1476 12 - - HYPH cord-015365-iqdi99pd 1476 13 Spezies Spezies NNP cord-015365-iqdi99pd 1476 14 ) ) -RRB- cord-015365-iqdi99pd 1477 1 , , , cord-015365-iqdi99pd 1477 2 die die VB cord-015365-iqdi99pd 1477 3 insbesondere insbesondere FW cord-015365-iqdi99pd 1477 4 bei bei NNP cord-015365-iqdi99pd 1477 5 Patienten Patienten NNP cord-015365-iqdi99pd 1477 6 mit mit NNP cord-015365-iqdi99pd 1477 7 Diabetes Diabetes NNP cord-015365-iqdi99pd 1477 8 mellitus mellitus NN cord-015365-iqdi99pd 1477 9 oder oder NN cord-015365-iqdi99pd 1477 10 zunehmend zunehmend NNP cord-015365-iqdi99pd 1477 11 bei bei NNP cord-015365-iqdi99pd 1477 12 immunsupprimierten immunsupprimierten NNP cord-015365-iqdi99pd 1477 13 Patienten Patienten NNP cord-015365-iqdi99pd 1477 14 unter unter NNP cord-015365-iqdi99pd 1477 15 Voriconazol Voriconazol NNP cord-015365-iqdi99pd 1477 16 Therapie Therapie NNP cord-015365-iqdi99pd 1477 17 auftreten auftreten NN cord-015365-iqdi99pd 1477 18 . . . cord-015365-iqdi99pd 1478 1 Die die VB cord-015365-iqdi99pd 1478 2 Letalität Letalität NNP cord-015365-iqdi99pd 1478 3 beim beim NNP cord-015365-iqdi99pd 1479 1 Immungeschwächten Immungeschwächten NNP cord-015365-iqdi99pd 1479 2 ist ist NNP cord-015365-iqdi99pd 1479 3 annähernd annähernd NNP cord-015365-iqdi99pd 1480 1 100 100 CD cord-015365-iqdi99pd 1480 2 % % NN cord-015365-iqdi99pd 1480 3 . . . cord-015365-iqdi99pd 1481 1 Bei Bei NNP cord-015365-iqdi99pd 1481 2 Empfängern empfängern JJ cord-015365-iqdi99pd 1481 3 solider solider NN cord-015365-iqdi99pd 1481 4 Organtransplantate Organtransplantate NNP cord-015365-iqdi99pd 1481 5 konnte konnte NNP cord-015365-iqdi99pd 1481 6 durch durch NNP cord-015365-iqdi99pd 1481 7 Neuerungen Neuerungen NNP cord-015365-iqdi99pd 1481 8 in in IN cord-015365-iqdi99pd 1481 9 der der NNP cord-015365-iqdi99pd 1481 10 Chirurgie Chirurgie NNP cord-015365-iqdi99pd 1481 11 und und XX cord-015365-iqdi99pd 1482 1 Intensivierung Intensivierung NNP cord-015365-iqdi99pd 1482 2 der der NN cord-015365-iqdi99pd 1482 3 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 1482 4 das das NNP cord-015365-iqdi99pd 1482 5 Transplantatü Transplantatü NNP cord-015365-iqdi99pd 1482 6 berleben berleben NN cord-015365-iqdi99pd 1482 7 verbessert verbessert NNP cord-015365-iqdi99pd 1482 8 werden werden NNP cord-015365-iqdi99pd 1482 9 . . . cord-015365-iqdi99pd 1483 1 Mit Mit NNP cord-015365-iqdi99pd 1483 2 bis bis NNP cord-015365-iqdi99pd 1483 3 zu zu XX cord-015365-iqdi99pd 1484 1 15 15 CD cord-015365-iqdi99pd 1484 2 % % NN cord-015365-iqdi99pd 1484 3 ist ist NN cord-015365-iqdi99pd 1484 4 die die VBP cord-015365-iqdi99pd 1485 1 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 1485 2 bei bei NNP cord-015365-iqdi99pd 1485 3 Herzund Herzund NNP cord-015365-iqdi99pd 1485 4 Lungentransplantation Lungentransplantation NNP cord-015365-iqdi99pd 1485 5 am be VBP cord-015365-iqdi99pd 1485 6 höchsten höchsten NNP cord-015365-iqdi99pd 1485 7 . . . cord-015365-iqdi99pd 1486 1 Nach Nach NNP cord-015365-iqdi99pd 1486 2 Lungentransplantation Lungentransplantation NNP cord-015365-iqdi99pd 1486 3 treten treten NNP cord-015365-iqdi99pd 1486 4 neben neben NNP cord-015365-iqdi99pd 1486 5 der der NNP cord-015365-iqdi99pd 1486 6 typischen typischen NNP cord-015365-iqdi99pd 1486 7 pulmonalen pulmonalen NNP cord-015365-iqdi99pd 1487 1 Aspergillose Aspergillose NNP cord-015365-iqdi99pd 1487 2 gehäuft gehäuft NNP cord-015365-iqdi99pd 1488 1 ulzerierende ulzerierende NNP cord-015365-iqdi99pd 1488 2 Tracheobronchitis Tracheobronchitis NNP cord-015365-iqdi99pd 1488 3 und und IN cord-015365-iqdi99pd 1488 4 Aspergillose Aspergillose NNP cord-015365-iqdi99pd 1488 5 der der NNP cord-015365-iqdi99pd 1488 6 Bronchusanastomose Bronchusanastomose NNP cord-015365-iqdi99pd 1488 7 auf auf NNP cord-015365-iqdi99pd 1488 8 . . . cord-015365-iqdi99pd 1489 1 Das Das NNP cord-015365-iqdi99pd 1489 2 geringste geringste NNP cord-015365-iqdi99pd 1490 1 Risiko Risiko NNP cord-015365-iqdi99pd 1490 2 einer einer NNP cord-015365-iqdi99pd 1490 3 invasiven invasiven NNP cord-015365-iqdi99pd 1490 4 Aspergillose Aspergillose NNP cord-015365-iqdi99pd 1490 5 besteht besteht NNP cord-015365-iqdi99pd 1490 6 bei bei NNP cord-015365-iqdi99pd 1490 7 Nierentransplantierten Nierentransplantierten NNP cord-015365-iqdi99pd 1490 8 mit mit NNP cord-015365-iqdi99pd 1490 9 1 1 CD cord-015365-iqdi99pd 1490 10 % % NN cord-015365-iqdi99pd 1490 11 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 1490 12 , , , cord-015365-iqdi99pd 1490 13 die die VB cord-015365-iqdi99pd 1490 14 Mortalität Mortalität NNP cord-015365-iqdi99pd 1490 15 ist ist FW cord-015365-iqdi99pd 1490 16 generell generell FW cord-015365-iqdi99pd 1490 17 hoch hoch NN cord-015365-iqdi99pd 1490 18 . . . cord-015365-iqdi99pd 1491 1 Institut Institut NNP cord-015365-iqdi99pd 1491 2 für für IN cord-015365-iqdi99pd 1491 3 Hygiene Hygiene NNP cord-015365-iqdi99pd 1491 4 , , , cord-015365-iqdi99pd 1491 5 Mikrobiologie Mikrobiologie NNP cord-015365-iqdi99pd 1491 6 und und IN cord-015365-iqdi99pd 1491 7 Umweltmedizin Umweltmedizin NNP cord-015365-iqdi99pd 1491 8 , , , cord-015365-iqdi99pd 1491 9 Medizinische Medizinische NNP cord-015365-iqdi99pd 1491 10 Universität Universität NNP cord-015365-iqdi99pd 1491 11 Graz Graz NNP cord-015365-iqdi99pd 1491 12 , , , cord-015365-iqdi99pd 1491 13 Graz Graz NNP cord-015365-iqdi99pd 1491 14 , , , cord-015365-iqdi99pd 1491 15 Österreich Österreich NNP cord-015365-iqdi99pd 1491 16 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1491 17 spielen spielen NNP cord-015365-iqdi99pd 1491 18 bei bei NNP cord-015365-iqdi99pd 1491 19 Immunsupprimierten Immunsupprimierten NNP cord-015365-iqdi99pd 1491 20 , , , cord-015365-iqdi99pd 1491 21 vor vor NNP cord-015365-iqdi99pd 1491 22 allem allem FW cord-015365-iqdi99pd 1491 23 bei bei NNP cord-015365-iqdi99pd 1491 24 Patientinnen Patientinnen NNP cord-015365-iqdi99pd 1491 25 und und XX cord-015365-iqdi99pd 1492 1 Patienten Patienten NNP cord-015365-iqdi99pd 1492 2 nach nach NNP cord-015365-iqdi99pd 1492 3 Organ Organ NNP cord-015365-iqdi99pd 1492 4 - - HYPH cord-015365-iqdi99pd 1492 5 und und NNP cord-015365-iqdi99pd 1492 6 Stammzelltransplantationen Stammzelltransplantationen NNP cord-015365-iqdi99pd 1492 7 , , , cord-015365-iqdi99pd 1492 8 eine eine NNP cord-015365-iqdi99pd 1492 9 steigende steigende NNP cord-015365-iqdi99pd 1492 10 Rolle Rolle NNP cord-015365-iqdi99pd 1492 11 . . . cord-015365-iqdi99pd 1493 1 Dabei Dabei NNP cord-015365-iqdi99pd 1493 2 reicht reicht NNP cord-015365-iqdi99pd 1493 3 das das NNP cord-015365-iqdi99pd 1493 4 Spektrum Spektrum NNP cord-015365-iqdi99pd 1493 5 der der NNP cord-015365-iqdi99pd 1493 6 verursachenden verursachenden NNP cord-015365-iqdi99pd 1494 1 Pilze Pilze NNP cord-015365-iqdi99pd 1494 2 von von NNP cord-015365-iqdi99pd 1494 3 Hefen Hefen NNP cord-015365-iqdi99pd 1494 4 der der NNP cord-015365-iqdi99pd 1494 5 Gattung Gattung NNP cord-015365-iqdi99pd 1494 6 Candida Candida NNP cord-015365-iqdi99pd 1495 1 zu zu NNP cord-015365-iqdi99pd 1495 2 Schimmelpilzen Schimmelpilzen NNP cord-015365-iqdi99pd 1495 3 der der NNP cord-015365-iqdi99pd 1495 4 Gattung Gattung NNP cord-015365-iqdi99pd 1495 5 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1495 6 , , , cord-015365-iqdi99pd 1495 7 wobei wobei FW cord-015365-iqdi99pd 1495 8 auch auch NNP cord-015365-iqdi99pd 1495 9 eine eine NNP cord-015365-iqdi99pd 1495 10 Zunahme Zunahme NNP cord-015365-iqdi99pd 1495 11 von von NNP cord-015365-iqdi99pd 1495 12 Infektionen Infektionen NNP cord-015365-iqdi99pd 1495 13 mit mit NNP cord-015365-iqdi99pd 1495 14 anderen anderen NNP cord-015365-iqdi99pd 1495 15 Schimmelpilzen Schimmelpilzen NNP cord-015365-iqdi99pd 1496 1 wie wie NNP cord-015365-iqdi99pd 1496 2 den den NNP cord-015365-iqdi99pd 1496 3 Zygomyzeten Zygomyzeten NNP cord-015365-iqdi99pd 1496 4 , , , cord-015365-iqdi99pd 1497 1 Fusarien Fusarien NNP cord-015365-iqdi99pd 1497 2 , , , cord-015365-iqdi99pd 1497 3 Scedosporium Scedosporium NNP cord-015365-iqdi99pd 1497 4 / / SYM cord-015365-iqdi99pd 1497 5 Pseudallescheria Pseudallescheria NNP cord-015365-iqdi99pd 1497 6 und und XX cord-015365-iqdi99pd 1498 1 anderen anderen NNP cord-015365-iqdi99pd 1498 2 zu zu NNP cord-015365-iqdi99pd 1498 3 beobachten beobachten NNP cord-015365-iqdi99pd 1498 4 ist ist NNP cord-015365-iqdi99pd 1498 5 . . . cord-015365-iqdi99pd 1499 1 Um um UH cord-015365-iqdi99pd 1499 2 eine eine NNP cord-015365-iqdi99pd 1499 3 zielgerichtete zielgerichtete NNP cord-015365-iqdi99pd 1499 4 Therapie Therapie NNP cord-015365-iqdi99pd 1499 5 einleiten einleiten FW cord-015365-iqdi99pd 1499 6 zu zu NNP cord-015365-iqdi99pd 1499 7 können können NNP cord-015365-iqdi99pd 1499 8 , , , cord-015365-iqdi99pd 1499 9 ist ist NNP cord-015365-iqdi99pd 1499 10 eine eine NNP cord-015365-iqdi99pd 1499 11 schnelle schnelle NNP cord-015365-iqdi99pd 1500 1 und und NNP cord-015365-iqdi99pd 1500 2 genaue genaue NNP cord-015365-iqdi99pd 1500 3 Diagnostik Diagnostik NNP cord-015365-iqdi99pd 1500 4 unumgänglich unumgänglich NNP cord-015365-iqdi99pd 1500 5 , , , cord-015365-iqdi99pd 1500 6 da da NNP cord-015365-iqdi99pd 1500 7 die die NNP cord-015365-iqdi99pd 1500 8 einzelnen einzelnen NNP cord-015365-iqdi99pd 1500 9 Pilzarten Pilzarten NNP cord-015365-iqdi99pd 1500 10 teils teils NNP cord-015365-iqdi99pd 1500 11 unterschiedliche unterschiedliche NN cord-015365-iqdi99pd 1500 12 Antimykotika Antimykotika NNP cord-015365-iqdi99pd 1500 13 - - HYPH cord-015365-iqdi99pd 1500 14 Empfindlichkeitsspektren Empfindlichkeitsspektren NNP cord-015365-iqdi99pd 1500 15 aufweisen aufweisen NN cord-015365-iqdi99pd 1500 16 . . . cord-015365-iqdi99pd 1501 1 Neben Neben NNP cord-015365-iqdi99pd 1501 2 den den NNP cord-015365-iqdi99pd 1501 3 klassischen klassischen NNP cord-015365-iqdi99pd 1501 4 Kulturmethoden Kulturmethoden NNP cord-015365-iqdi99pd 1501 5 , , , cord-015365-iqdi99pd 1501 6 die die VBP cord-015365-iqdi99pd 1501 7 trotz trotz NNP cord-015365-iqdi99pd 1501 8 ihrer ihrer JJ cord-015365-iqdi99pd 1501 9 relativen relativen NNP cord-015365-iqdi99pd 1501 10 " " '' cord-015365-iqdi99pd 1502 1 Langsamkeit Langsamkeit NNP cord-015365-iqdi99pd 1502 2 " " `` cord-015365-iqdi99pd 1502 3 nach nach NNP cord-015365-iqdi99pd 1502 4 wie wie NN cord-015365-iqdi99pd 1502 5 vor vor NNP cord-015365-iqdi99pd 1502 6 unverzichtbar unverzichtbar NN cord-015365-iqdi99pd 1502 7 sind sind NNP cord-015365-iqdi99pd 1502 8 , , , cord-015365-iqdi99pd 1502 9 wurden wurden NNP cord-015365-iqdi99pd 1502 10 in in IN cord-015365-iqdi99pd 1502 11 den den NNP cord-015365-iqdi99pd 1502 12 letzten letzten NNP cord-015365-iqdi99pd 1502 13 Jahren Jahren NNP cord-015365-iqdi99pd 1502 14 Techniken Techniken NNP cord-015365-iqdi99pd 1502 15 entwickelt entwickelt NNP cord-015365-iqdi99pd 1502 16 , , , cord-015365-iqdi99pd 1502 17 die die VB cord-015365-iqdi99pd 1503 1 teilweise teilweise NNP cord-015365-iqdi99pd 1503 2 innerhalb innerhalb NNP cord-015365-iqdi99pd 1503 3 weniger weniger NNP cord-015365-iqdi99pd 1503 4 Stunden Stunden NNP cord-015365-iqdi99pd 1503 5 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1503 6 bringen bringen NNP cord-015365-iqdi99pd 1503 7 können können RB cord-015365-iqdi99pd 1503 8 -vorausgesetzt -vorausgesetzt VBD cord-015365-iqdi99pd 1503 9 , , , cord-015365-iqdi99pd 1504 1 sie sie NNP cord-015365-iqdi99pd 1504 2 werden werden NNP cord-015365-iqdi99pd 1504 3 richtig richtig NNP cord-015365-iqdi99pd 1504 4 angewandt angewandt NNP cord-015365-iqdi99pd 1504 5 und und NNP cord-015365-iqdi99pd 1504 6 interpretiert interpretiert NNP cord-015365-iqdi99pd 1504 7 . . . cord-015365-iqdi99pd 1505 1 Dazu Dazu NNP cord-015365-iqdi99pd 1505 2 zählen zählen VBP cord-015365-iqdi99pd 1505 3 insbesondere insbesondere NNP cord-015365-iqdi99pd 1505 4 bildgebende bildgebende NNP cord-015365-iqdi99pd 1505 5 Verfahren Verfahren NNP cord-015365-iqdi99pd 1505 6 , , , cord-015365-iqdi99pd 1505 7 molekularbiologische molekularbiologische NN cord-015365-iqdi99pd 1505 8 Methoden Methoden NNP cord-015365-iqdi99pd 1505 9 und und IN cord-015365-iqdi99pd 1505 10 Antigen Antigen NNP cord-015365-iqdi99pd 1505 11 - - HYPH cord-015365-iqdi99pd 1505 12 Nachweise Nachweise NNP cord-015365-iqdi99pd 1505 13 . . . cord-015365-iqdi99pd 1506 1 Idealerweise Idealerweise NNP cord-015365-iqdi99pd 1506 2 beruht beruht NN cord-015365-iqdi99pd 1506 3 die die VB cord-015365-iqdi99pd 1507 1 Diagnose diagnose VB cord-015365-iqdi99pd 1507 2 einer einer NNP cord-015365-iqdi99pd 1508 1 Pilzinfektion Pilzinfektion NNP cord-015365-iqdi99pd 1508 2 auf auf NNP cord-015365-iqdi99pd 1508 3 der der NNP cord-015365-iqdi99pd 1508 4 Kombination Kombination NNP cord-015365-iqdi99pd 1508 5 mehrerer mehrerer NN cord-015365-iqdi99pd 1508 6 Techniken Techniken NNP cord-015365-iqdi99pd 1508 7 , , , cord-015365-iqdi99pd 1508 8 man man NN cord-015365-iqdi99pd 1508 9 spricht spricht FW cord-015365-iqdi99pd 1508 10 auch auch NNP cord-015365-iqdi99pd 1508 11 von von NNP cord-015365-iqdi99pd 1508 12 einer einer NNP cord-015365-iqdi99pd 1508 13 Puzzle Puzzle NNP cord-015365-iqdi99pd 1508 14 - - HYPH cord-015365-iqdi99pd 1508 15 Diagnostik Diagnostik NNP cord-015365-iqdi99pd 1508 16 . . . cord-015365-iqdi99pd 1509 1 Die die VB cord-015365-iqdi99pd 1509 2 einzelnen einzelnen NNP cord-015365-iqdi99pd 1510 1 Techniken Techniken NNP cord-015365-iqdi99pd 1510 2 zur zur NNP cord-015365-iqdi99pd 1510 3 Diagnose diagnose VBP cord-015365-iqdi99pd 1510 4 von von NNP cord-015365-iqdi99pd 1510 5 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1510 6 in in IN cord-015365-iqdi99pd 1510 7 der der NNP cord-015365-iqdi99pd 1510 8 Organ Organ NNP cord-015365-iqdi99pd 1510 9 - - HYPH cord-015365-iqdi99pd 1510 10 und und NNP cord-015365-iqdi99pd 1510 11 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 1510 12 sollen sollen NNP cord-015365-iqdi99pd 1510 13 vorgestellt vorgestellt NNP cord-015365-iqdi99pd 1510 14 und und IN cord-015365-iqdi99pd 1510 15 deren deren NNP cord-015365-iqdi99pd 1510 16 Vor Vor NNP cord-015365-iqdi99pd 1510 17 - - HYPH cord-015365-iqdi99pd 1510 18 und und NNP cord-015365-iqdi99pd 1510 19 Nachteile Nachteile NNP cord-015365-iqdi99pd 1510 20 diskutiert diskutiert NN cord-015365-iqdi99pd 1510 21 werden werden NNP cord-015365-iqdi99pd 1510 22 . . . cord-015365-iqdi99pd 1511 1 Therapie Therapie NNP cord-015365-iqdi99pd 1511 2 von von NNP cord-015365-iqdi99pd 1511 3 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1511 4 in in IN cord-015365-iqdi99pd 1511 5 der der NNP cord-015365-iqdi99pd 1511 6 Organ Organ NNP cord-015365-iqdi99pd 1511 7 - - HYPH cord-015365-iqdi99pd 1511 8 und und NNP cord-015365-iqdi99pd 1511 9 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 1511 10 Universitätsklinik Universitätsklinik NNP cord-015365-iqdi99pd 1511 11 für für IN cord-015365-iqdi99pd 1511 12 Innere Innere NNP cord-015365-iqdi99pd 1511 13 Medizin Medizin NNP cord-015365-iqdi99pd 1511 14 , , , cord-015365-iqdi99pd 1512 1 Medizinische Medizinische NNP cord-015365-iqdi99pd 1512 2 Universität Universität NNP cord-015365-iqdi99pd 1512 3 Graz Graz NNP cord-015365-iqdi99pd 1512 4 , , , cord-015365-iqdi99pd 1512 5 Graz Graz NNP cord-015365-iqdi99pd 1512 6 , , , cord-015365-iqdi99pd 1512 7 Österreich Österreich NNP cord-015365-iqdi99pd 1512 8 Pilze Pilze NNP cord-015365-iqdi99pd 1512 9 verursachen verursachen NN cord-015365-iqdi99pd 1512 10 bei bei NNP cord-015365-iqdi99pd 1512 11 Immunsupprimierten Immunsupprimierten NNP cord-015365-iqdi99pd 1512 12 infektiöse infektiöse NNP cord-015365-iqdi99pd 1512 13 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 1512 14 , , , cord-015365-iqdi99pd 1512 15 die die VB cord-015365-iqdi99pd 1512 16 von von NNP cord-015365-iqdi99pd 1512 17 oberflächlichen oberflächlichen NNP cord-015365-iqdi99pd 1513 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 1513 2 der der NN cord-015365-iqdi99pd 1513 3 Haut/ Haut/ NNP cord-015365-iqdi99pd 1513 4 Schleimhäute Schleimhäute NNP cord-015365-iqdi99pd 1513 5 bis bis NNP cord-015365-iqdi99pd 1513 6 zu zu NNP cord-015365-iqdi99pd 1513 7 systemischen systemischen NNP cord-015365-iqdi99pd 1513 8 , , , cord-015365-iqdi99pd 1513 9 lebensbedrohlichen lebensbedrohlichen NNP cord-015365-iqdi99pd 1513 10 Organinfektionen Organinfektionen NNP cord-015365-iqdi99pd 1513 11 oder oder NNP cord-015365-iqdi99pd 1513 12 Fungämien Fungämien NNP cord-015365-iqdi99pd 1513 13 reichen reichen NNP cord-015365-iqdi99pd 1513 14 . . . cord-015365-iqdi99pd 1514 1 Auslöser Auslöser NNP cord-015365-iqdi99pd 1514 2 dieser dieser NNP cord-015365-iqdi99pd 1515 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 1515 2 sind sind NNP cord-015365-iqdi99pd 1516 1 meist meist NNP cord-015365-iqdi99pd 1516 2 Candida Candida NNP cord-015365-iqdi99pd 1516 3 - - HYPH cord-015365-iqdi99pd 1516 4 Arten Arten NNP cord-015365-iqdi99pd 1516 5 , , , cord-015365-iqdi99pd 1516 6 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1516 7 - - HYPH cord-015365-iqdi99pd 1516 8 Arten Arten NNP cord-015365-iqdi99pd 1516 9 , , , cord-015365-iqdi99pd 1516 10 andere andere JJ cord-015365-iqdi99pd 1516 11 Schimmelpilze Schimmelpilze NNP cord-015365-iqdi99pd 1516 12 wie wie NNP cord-015365-iqdi99pd 1516 13 Zygomyceten Zygomyceten NNP cord-015365-iqdi99pd 1516 14 , , , cord-015365-iqdi99pd 1516 15 und und CC cord-015365-iqdi99pd 1516 16 seltene seltene NNP cord-015365-iqdi99pd 1516 17 andere andere NNP cord-015365-iqdi99pd 1516 18 Pilze Pilze NNP cord-015365-iqdi99pd 1516 19 . . . cord-015365-iqdi99pd 1517 1 Zur Zur NNP cord-015365-iqdi99pd 1517 2 Therapie Therapie NNP cord-015365-iqdi99pd 1517 3 der der NN cord-015365-iqdi99pd 1517 4 systemischen systemischen NNS cord-015365-iqdi99pd 1517 5 Infektionen Infektionen NNP cord-015365-iqdi99pd 1517 6 stehen stehen NNP cord-015365-iqdi99pd 1517 7 Polyene Polyene NNP cord-015365-iqdi99pd 1517 8 ( ( -LRB- cord-015365-iqdi99pd 1517 9 z. z. NNP cord-015365-iqdi99pd 1517 10 B. B. NNP cord-015365-iqdi99pd 1517 11 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1517 12 B B NNP cord-015365-iqdi99pd 1517 13 , , , cord-015365-iqdi99pd 1517 14 lipid lipid NN cord-015365-iqdi99pd 1517 15 - - HYPH cord-015365-iqdi99pd 1517 16 assoziierte assoziierte NN cord-015365-iqdi99pd 1517 17 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1517 18 B B NNP cord-015365-iqdi99pd 1517 19 Präparate Präparate NNP cord-015365-iqdi99pd 1517 20 ) ) -RRB- cord-015365-iqdi99pd 1517 21 , , , cord-015365-iqdi99pd 1517 22 Azole Azole NNP cord-015365-iqdi99pd 1517 23 ( ( -LRB- cord-015365-iqdi99pd 1517 24 z. z. NNP cord-015365-iqdi99pd 1517 25 B. B. NNP cord-015365-iqdi99pd 1517 26 Fuconazol Fuconazol NNP cord-015365-iqdi99pd 1517 27 , , , cord-015365-iqdi99pd 1517 28 Itraconazol Itraconazol NNP cord-015365-iqdi99pd 1517 29 , , , cord-015365-iqdi99pd 1517 30 Voriconazol Voriconazol NNP cord-015365-iqdi99pd 1517 31 , , , cord-015365-iqdi99pd 1517 32 Posaconazol Posaconazol NNP cord-015365-iqdi99pd 1517 33 ) ) -RRB- cord-015365-iqdi99pd 1517 34 und und CC cord-015365-iqdi99pd 1517 35 Echinocandine Echinocandine NNP cord-015365-iqdi99pd 1517 36 ( ( -LRB- cord-015365-iqdi99pd 1517 37 z. z. NNP cord-015365-iqdi99pd 1517 38 B. B. NNP cord-015365-iqdi99pd 1517 39 Caspofungin Caspofungin NNP cord-015365-iqdi99pd 1517 40 , , , cord-015365-iqdi99pd 1517 41 Anidulafungin Anidulafungin NNP cord-015365-iqdi99pd 1517 42 , , , cord-015365-iqdi99pd 1517 43 Micafungin Micafungin NNP cord-015365-iqdi99pd 1517 44 ) ) -RRB- cord-015365-iqdi99pd 1517 45 zur zur NNP cord-015365-iqdi99pd 1517 46 Verfügung Verfügung NNP cord-015365-iqdi99pd 1517 47 . . . cord-015365-iqdi99pd 1518 1 Fluconazol Fluconazol NNP cord-015365-iqdi99pd 1518 2 ist ist NNP cord-015365-iqdi99pd 1518 3 ausschließlich ausschließlich NNS cord-015365-iqdi99pd 1518 4 gegen gegen NNP cord-015365-iqdi99pd 1518 5 Candida Candida NNP cord-015365-iqdi99pd 1518 6 Arten Arten NNP cord-015365-iqdi99pd 1518 7 wirksam wirksam NN cord-015365-iqdi99pd 1518 8 . . . cord-015365-iqdi99pd 1519 1 Die die VB cord-015365-iqdi99pd 1519 2 anderen anderen NNP cord-015365-iqdi99pd 1519 3 oben oben NNP cord-015365-iqdi99pd 1519 4 genannnten genannnten NNP cord-015365-iqdi99pd 1520 1 Antimykotika Antimykotika NNP cord-015365-iqdi99pd 1520 2 sind sind NNP cord-015365-iqdi99pd 1520 3 in in IN cord-015365-iqdi99pd 1520 4 vitro vitro FW cord-015365-iqdi99pd 1520 5 sowohl sowohl NNP cord-015365-iqdi99pd 1520 6 gegen gegen NNP cord-015365-iqdi99pd 1520 7 Candida Candida NNP cord-015365-iqdi99pd 1520 8 - - HYPH cord-015365-iqdi99pd 1520 9 als als NNP cord-015365-iqdi99pd 1520 10 auch auch JJ cord-015365-iqdi99pd 1520 11 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1520 12 - - HYPH cord-015365-iqdi99pd 1520 13 Arten Arten NNP cord-015365-iqdi99pd 1520 14 wirksam wirksam NN cord-015365-iqdi99pd 1520 15 . . . cord-015365-iqdi99pd 1521 1 Für Für NNP cord-015365-iqdi99pd 1521 2 die die VBP cord-015365-iqdi99pd 1522 1 Therapie Therapie NNP cord-015365-iqdi99pd 1522 2 von von NNP cord-015365-iqdi99pd 1523 1 Candida Candida NNP cord-015365-iqdi99pd 1523 2 - - HYPH cord-015365-iqdi99pd 1523 3 Infektionen Infektionen NNP cord-015365-iqdi99pd 1523 4 eignen eignen NNP cord-015365-iqdi99pd 1523 5 sich sich NNP cord-015365-iqdi99pd 1523 6 abhängig abhängig NNP cord-015365-iqdi99pd 1523 7 von von NNP cord-015365-iqdi99pd 1523 8 der der NNP cord-015365-iqdi99pd 1523 9 lokalen lokalen NNP cord-015365-iqdi99pd 1523 10 Epidemiologie Epidemiologie NNP cord-015365-iqdi99pd 1523 11 Fluconazol Fluconazol NNP cord-015365-iqdi99pd 1523 12 , , , cord-015365-iqdi99pd 1523 13 Echinocandine Echinocandine NNP cord-015365-iqdi99pd 1523 14 oder oder NN cord-015365-iqdi99pd 1523 15 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1523 16 B B NNP cord-015365-iqdi99pd 1523 17 - - HYPH cord-015365-iqdi99pd 1523 18 Präparate Präparate NNP cord-015365-iqdi99pd 1523 19 . . . cord-015365-iqdi99pd 1524 1 Für Für NNP cord-015365-iqdi99pd 1524 2 die die VBP cord-015365-iqdi99pd 1524 3 Therapie Therapie NNP cord-015365-iqdi99pd 1524 4 von von NNP cord-015365-iqdi99pd 1524 5 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1524 6 - - HYPH cord-015365-iqdi99pd 1524 7 Infektionen Infektionen NNP cord-015365-iqdi99pd 1524 8 eignen eignen NNP cord-015365-iqdi99pd 1524 9 sich sich NNP cord-015365-iqdi99pd 1524 10 Voriconazol Voriconazol NNP cord-015365-iqdi99pd 1524 11 , , , cord-015365-iqdi99pd 1524 12 Posaconazol Posaconazol NNP cord-015365-iqdi99pd 1524 13 , , , cord-015365-iqdi99pd 1524 14 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1524 15 B B NNP cord-015365-iqdi99pd 1524 16 - - HYPH cord-015365-iqdi99pd 1524 17 Präparate Präparate NNP cord-015365-iqdi99pd 1524 18 oder oder NN cord-015365-iqdi99pd 1524 19 Echinocandine Echinocandine NNP cord-015365-iqdi99pd 1524 20 . . . cord-015365-iqdi99pd 1525 1 Für Für NNP cord-015365-iqdi99pd 1525 2 Zygomkosen Zygomkosen NNP cord-015365-iqdi99pd 1525 3 stehen stehen NN cord-015365-iqdi99pd 1525 4 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1525 5 B B NNP cord-015365-iqdi99pd 1525 6 - - : cord-015365-iqdi99pd 1525 7 Präparate Präparate NNP cord-015365-iqdi99pd 1525 8 und und IN cord-015365-iqdi99pd 1525 9 Posaconazol Posaconazol NNP cord-015365-iqdi99pd 1525 10 zu zu NNP cord-015365-iqdi99pd 1525 11 Verfügung Verfügung NNP cord-015365-iqdi99pd 1525 12 . . . cord-015365-iqdi99pd 1526 1 Für Für NNP cord-015365-iqdi99pd 1526 2 seltene seltene NNP cord-015365-iqdi99pd 1527 1 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1527 2 sind sind NNP cord-015365-iqdi99pd 1528 1 adjuvante adjuvante NNP cord-015365-iqdi99pd 1528 2 Therapeutika Therapeutika NNP cord-015365-iqdi99pd 1529 1 ( ( -LRB- cord-015365-iqdi99pd 1529 2 wie wie NNP cord-015365-iqdi99pd 1529 3 z. z. NNP cord-015365-iqdi99pd 1529 4 B. B. NNP cord-015365-iqdi99pd 1529 5 Flucytosin Flucytosin NNP cord-015365-iqdi99pd 1529 6 ) ) -RRB- cord-015365-iqdi99pd 1529 7 vorhanden vorhanden NNP cord-015365-iqdi99pd 1529 8 . . . cord-015365-iqdi99pd 1530 1 Für Für NNP cord-015365-iqdi99pd 1530 2 den den NNP cord-015365-iqdi99pd 1530 3 Behandlungserfolg Behandlungserfolg NNP cord-015365-iqdi99pd 1530 4 der der NNP cord-015365-iqdi99pd 1530 5 schweren schweren NNP cord-015365-iqdi99pd 1530 6 lebensbedrohlichen lebensbedrohlichen NNP cord-015365-iqdi99pd 1531 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 1531 2 ist ist NN cord-015365-iqdi99pd 1531 3 der der NNP cord-015365-iqdi99pd 1531 4 Zeitpunkt Zeitpunkt NNP cord-015365-iqdi99pd 1531 5 des des FW cord-015365-iqdi99pd 1531 6 Therapiebeginns Therapiebeginns NNP cord-015365-iqdi99pd 1531 7 und und IN cord-015365-iqdi99pd 1531 8 das das NNP cord-015365-iqdi99pd 1531 9 Spektrum Spektrum NNP cord-015365-iqdi99pd 1531 10 der der NNP cord-015365-iqdi99pd 1531 11 antifungalen antifungalen NNP cord-015365-iqdi99pd 1531 12 Therapie Therapie NNP cord-015365-iqdi99pd 1531 13 relevant relevant JJ cord-015365-iqdi99pd 1531 14 . . . cord-015365-iqdi99pd 1532 1 Es Es NNP cord-015365-iqdi99pd 1532 2 werden werden NNP cord-015365-iqdi99pd 1532 3 empirische empirische NNP cord-015365-iqdi99pd 1532 4 , , , cord-015365-iqdi99pd 1532 5 kalkuliert kalkuliert NNP cord-015365-iqdi99pd 1532 6 - - HYPH cord-015365-iqdi99pd 1532 7 präemptive präemptive NNP cord-015365-iqdi99pd 1532 8 und und IN cord-015365-iqdi99pd 1532 9 zielgerichtete zielgerichtete NNP cord-015365-iqdi99pd 1532 10 Therapien Therapien NNP cord-015365-iqdi99pd 1532 11 unterschieden unterschieden JJ cord-015365-iqdi99pd 1532 12 . . . cord-015365-iqdi99pd 1533 1 Bei Bei NNP cord-015365-iqdi99pd 1533 2 machne machne NNP cord-015365-iqdi99pd 1534 1 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1534 2 sind sind NNP cord-015365-iqdi99pd 1535 1 chirurgische chirurgische NNP cord-015365-iqdi99pd 1535 2 Sanierungen Sanierungen NNP cord-015365-iqdi99pd 1535 3 zusätzlich zusätzlich NNP cord-015365-iqdi99pd 1535 4 zur zur NNP cord-015365-iqdi99pd 1535 5 antimykotischen antimykotischen NNP cord-015365-iqdi99pd 1535 6 Therapie Therapie NNP cord-015365-iqdi99pd 1535 7 notwendig notwendig NNP cord-015365-iqdi99pd 1535 8 . . . cord-015365-iqdi99pd 1536 1 Die die VB cord-015365-iqdi99pd 1536 2 einzelnen einzelnen NNP cord-015365-iqdi99pd 1537 1 Therapioptionen Therapioptionen NNP cord-015365-iqdi99pd 1537 2 zur zur NNP cord-015365-iqdi99pd 1537 3 Behandlung Behandlung NNP cord-015365-iqdi99pd 1537 4 von von NNP cord-015365-iqdi99pd 1537 5 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1537 6 in in IN cord-015365-iqdi99pd 1537 7 der der NNP cord-015365-iqdi99pd 1537 8 Organ Organ NNP cord-015365-iqdi99pd 1537 9 - - HYPH cord-015365-iqdi99pd 1537 10 und und NNP cord-015365-iqdi99pd 1537 11 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 1537 12 sollen sollen NNP cord-015365-iqdi99pd 1537 13 vorgestellt vorgestellt NNP cord-015365-iqdi99pd 1537 14 und und IN cord-015365-iqdi99pd 1537 15 deren deren NNP cord-015365-iqdi99pd 1537 16 Vor Vor NNP cord-015365-iqdi99pd 1537 17 - - HYPH cord-015365-iqdi99pd 1537 18 und und NNP cord-015365-iqdi99pd 1537 19 Nachteile Nachteile NNP cord-015365-iqdi99pd 1537 20 diskutiert diskutiert NN cord-015365-iqdi99pd 1537 21 werden werden NNP cord-015365-iqdi99pd 1537 22 . . . cord-015365-iqdi99pd 1538 1 Erlebenüberlebenund Erlebenüberlebenund NNP cord-015365-iqdi99pd 1538 2 dann dann NNP cord-015365-iqdi99pd 1538 3 ? ? . cord-015365-iqdi99pd 1539 1 Lebensqualität Lebensqualität NNS cord-015365-iqdi99pd 1539 2 nach nach VBP cord-015365-iqdi99pd 1539 3 Herztransplantation Herztransplantation NNP cord-015365-iqdi99pd 1539 4 Klinische Klinische NNP cord-015365-iqdi99pd 1539 5 Abteilung Abteilung NNP cord-015365-iqdi99pd 1539 6 für für IN cord-015365-iqdi99pd 1539 7 Herzchirurgie Herzchirurgie NNP cord-015365-iqdi99pd 1539 8 , , , cord-015365-iqdi99pd 1539 9 Universitätsklinik Universitätsklinik NNP cord-015365-iqdi99pd 1539 10 für für IN cord-015365-iqdi99pd 1539 11 Chirurgie Chirurgie NNP cord-015365-iqdi99pd 1539 12 , , , cord-015365-iqdi99pd 1539 13 Medizinische Medizinische NNP cord-015365-iqdi99pd 1539 14 Universität Universität NNP cord-015365-iqdi99pd 1539 15 Wien Wien NNP cord-015365-iqdi99pd 1539 16 , , , cord-015365-iqdi99pd 1539 17 Wien Wien NNP cord-015365-iqdi99pd 1539 18 , , , cord-015365-iqdi99pd 1539 19 Österreich Österreich NNP cord-015365-iqdi99pd 1539 20 Aus Aus NNP cord-015365-iqdi99pd 1539 21 wissenschaftlicher wissenschaftlicher CC cord-015365-iqdi99pd 1539 22 Perspektive Perspektive NNP cord-015365-iqdi99pd 1539 23 ist ist NN cord-015365-iqdi99pd 1539 24 der der NN cord-015365-iqdi99pd 1539 25 Begriff Begriff NNP cord-015365-iqdi99pd 1539 26 " " '' cord-015365-iqdi99pd 1539 27 Lebensqualität Lebensqualität NNPS cord-015365-iqdi99pd 1539 28 " " '' cord-015365-iqdi99pd 1539 29 ein ein FW cord-015365-iqdi99pd 1539 30 nicht nicht NNP cord-015365-iqdi99pd 1539 31 direkt direkt NN cord-015365-iqdi99pd 1539 32 beobachtbares beobachtbares NNP cord-015365-iqdi99pd 1539 33 Konstrukt Konstrukt NNP cord-015365-iqdi99pd 1539 34 , , , cord-015365-iqdi99pd 1540 1 das das NNP cord-015365-iqdi99pd 1540 2 die die VBP cord-015365-iqdi99pd 1540 3 Bewertung Bewertung NNP cord-015365-iqdi99pd 1540 4 des des NNP cord-015365-iqdi99pd 1540 5 physischen physischen NNP cord-015365-iqdi99pd 1540 6 , , , cord-015365-iqdi99pd 1540 7 psychischen psychischen NNP cord-015365-iqdi99pd 1540 8 und und IN cord-015365-iqdi99pd 1540 9 sozialen sozialen NNP cord-015365-iqdi99pd 1540 10 Zustandes Zustandes NNP cord-015365-iqdi99pd 1540 11 einer einer NNP cord-015365-iqdi99pd 1540 12 Person Person NNP cord-015365-iqdi99pd 1540 13 in in IN cord-015365-iqdi99pd 1540 14 seiner seiner NNP cord-015365-iqdi99pd 1540 15 Zusammenschau Zusammenschau NNP cord-015365-iqdi99pd 1540 16 bezeichnet bezeichnet NNP cord-015365-iqdi99pd 1540 17 . . . cord-015365-iqdi99pd 1541 1 Eine Eine NNP cord-015365-iqdi99pd 1541 2 gute gute NNP cord-015365-iqdi99pd 1541 3 Annäherung Annäherung NNP cord-015365-iqdi99pd 1541 4 kann kann NNP cord-015365-iqdi99pd 1541 5 auch auch NNP cord-015365-iqdi99pd 1541 6 durch durch NNP cord-015365-iqdi99pd 1541 7 den den NNP cord-015365-iqdi99pd 1541 8 Begriff Begriff NNP cord-015365-iqdi99pd 1541 9 " " '' cord-015365-iqdi99pd 1541 10 Lebenszufriedenheit Lebenszufriedenheit NNP cord-015365-iqdi99pd 1541 11 " " '' cord-015365-iqdi99pd 1541 12 erfolgen erfolgen NN cord-015365-iqdi99pd 1541 13 . . . cord-015365-iqdi99pd 1542 1 I -PRON- PRP cord-015365-iqdi99pd 1542 2 m be VBP cord-015365-iqdi99pd 1543 1 Vortrag Vortrag NNP cord-015365-iqdi99pd 1543 2 soll soll NNP cord-015365-iqdi99pd 1544 1 vor vor NNP cord-015365-iqdi99pd 1545 1 allem allem NNP cord-015365-iqdi99pd 1545 2 auf auf NNP cord-015365-iqdi99pd 1545 3 Langzeit Langzeit NNP cord-015365-iqdi99pd 1545 4 - - HYPH cord-015365-iqdi99pd 1545 5 Lebensqualitätsstudien Lebensqualitätsstudien NNP cord-015365-iqdi99pd 1546 1 und und NNP cord-015365-iqdi99pd 1546 2 die die VB cord-015365-iqdi99pd 1546 3 psychische psychische NNP cord-015365-iqdi99pd 1546 4 Verarbeitung Verarbeitung NNP cord-015365-iqdi99pd 1546 5 der der NNP cord-015365-iqdi99pd 1546 6 Herztransplantation Herztransplantation NNP cord-015365-iqdi99pd 1546 7 Bezug Bezug NNP cord-015365-iqdi99pd 1546 8 genommen genommen NNP cord-015365-iqdi99pd 1547 1 werden werden NNP cord-015365-iqdi99pd 1547 2 : : : cord-015365-iqdi99pd 1547 3 wie wie NNP cord-015365-iqdi99pd 1547 4 ändert ändert NNP cord-015365-iqdi99pd 1547 5 sich sich NNP cord-015365-iqdi99pd 1547 6 das das NNP cord-015365-iqdi99pd 1547 7 Leben Leben NNP cord-015365-iqdi99pd 1547 8 der der NNP cord-015365-iqdi99pd 1547 9 PatientInnen PatientInnen NNP cord-015365-iqdi99pd 1547 10 nach nach NNP cord-015365-iqdi99pd 1547 11 einer einer NNP cord-015365-iqdi99pd 1548 1 oft oft NNP cord-015365-iqdi99pd 1548 2 schicksalhaften schicksalhaften NNP cord-015365-iqdi99pd 1548 3 schweren schweren NNP cord-015365-iqdi99pd 1549 1 Erkrankung Erkrankung NNP cord-015365-iqdi99pd 1549 2 und und IN cord-015365-iqdi99pd 1549 3 lebenserhaltenden lebenserhaltenden JJ cord-015365-iqdi99pd 1549 4 Transplantation transplantation NN cord-015365-iqdi99pd 1549 5 ? ? . cord-015365-iqdi99pd 1550 1 In in IN cord-015365-iqdi99pd 1550 2 einer einer NNP cord-015365-iqdi99pd 1550 3 prospektiven prospektiven NNP cord-015365-iqdi99pd 1550 4 Studie Studie NNP cord-015365-iqdi99pd 1550 5 unserer unserer JJ cord-015365-iqdi99pd 1550 6 Abteilung Abteilung NNP cord-015365-iqdi99pd 1550 7 über über NNP cord-015365-iqdi99pd 1550 8 Lebensqualität Lebensqualität NNP cord-015365-iqdi99pd 1550 9 ein ein NNP cord-015365-iqdi99pd 1550 10 , , , cord-015365-iqdi99pd 1550 11 fünf fünf NNP cord-015365-iqdi99pd 1550 12 und und IN cord-015365-iqdi99pd 1550 13 10 10 CD cord-015365-iqdi99pd 1550 14 Jahre Jahre NNP cord-015365-iqdi99pd 1550 15 nach nach NNP cord-015365-iqdi99pd 1550 16 Herztransplantation Herztransplantation NNP cord-015365-iqdi99pd 1550 17 zeigte zeigte NNP cord-015365-iqdi99pd 1550 18 sich sich NNP cord-015365-iqdi99pd 1550 19 z. z. NNP cord-015365-iqdi99pd 1550 20 B. B. NNP cord-015365-iqdi99pd 1550 21 eine eine NNP cord-015365-iqdi99pd 1551 1 Schere Schere NNP cord-015365-iqdi99pd 1552 1 zwischen zwischen NNP cord-015365-iqdi99pd 1552 2 konstant konstant NNP cord-015365-iqdi99pd 1552 3 durchaus durchaus NNP cord-015365-iqdi99pd 1552 4 guter guter NNP cord-015365-iqdi99pd 1552 5 Lebensqualität Lebensqualität NNP cord-015365-iqdi99pd 1552 6 in in IN cord-015365-iqdi99pd 1552 7 physischer physischer NNP cord-015365-iqdi99pd 1552 8 und und NNP cord-015365-iqdi99pd 1552 9 zunehmend zunehmend NNP cord-015365-iqdi99pd 1552 10 abnehmender abnehmender NNP cord-015365-iqdi99pd 1552 11 Lebensqualität Lebensqualität NNP cord-015365-iqdi99pd 1552 12 in in IN cord-015365-iqdi99pd 1552 13 physischer physischer NNP cord-015365-iqdi99pd 1552 14 Hinsicht Hinsicht NNP cord-015365-iqdi99pd 1552 15 ( ( -LRB- cord-015365-iqdi99pd 1552 16 v. v. IN cord-015365-iqdi99pd 1552 17 a. a. NN cord-015365-iqdi99pd 1552 18 Depression depression NN cord-015365-iqdi99pd 1552 19 , , , cord-015365-iqdi99pd 1553 1 Labilität Labilität NNS cord-015365-iqdi99pd 1553 2 und und RB cord-015365-iqdi99pd 1554 1 Dysphorie Dysphorie NNP cord-015365-iqdi99pd 1554 2 ) ) -RRB- cord-015365-iqdi99pd 1554 3 . . . cord-015365-iqdi99pd 1555 1 Es Es NNP cord-015365-iqdi99pd 1555 2 werden werden NNP cord-015365-iqdi99pd 1555 3 Gründe Gründe NNP cord-015365-iqdi99pd 1555 4 für für IN cord-015365-iqdi99pd 1555 5 diese diese NNP cord-015365-iqdi99pd 1555 6 Differenz Differenz NNP cord-015365-iqdi99pd 1555 7 diskutiert diskutiert NNP cord-015365-iqdi99pd 1555 8 , , , cord-015365-iqdi99pd 1555 9 Lösungsmöglichkeiten Lösungsmöglichkeiten NNP cord-015365-iqdi99pd 1555 10 besprochen besprochen NNP cord-015365-iqdi99pd 1555 11 . . . cord-015365-iqdi99pd 1556 1 Ferner Ferner NNP cord-015365-iqdi99pd 1556 2 ist ist NN cord-015365-iqdi99pd 1556 3 die die VBP cord-015365-iqdi99pd 1556 4 Frage frage NN cord-015365-iqdi99pd 1556 5 interessant interessant JJ cord-015365-iqdi99pd 1556 6 , , , cord-015365-iqdi99pd 1557 1 ob ob NNP cord-015365-iqdi99pd 1557 2 Persönlichkeitsfaktoren Persönlichkeitsfaktoren NNP cord-015365-iqdi99pd 1557 3 Einfluß Einfluß NNP cord-015365-iqdi99pd 1557 4 haben haben VBP cord-015365-iqdi99pd 1557 5 auf auf NNP cord-015365-iqdi99pd 1557 6 Langzeitüberleben Langzeitüberleben NNP cord-015365-iqdi99pd 1557 7 und und IN cord-015365-iqdi99pd 1557 8 Lebensqualität Lebensqualität NNPS cord-015365-iqdi99pd 1557 9 bzw bzw NNP cord-015365-iqdi99pd 1557 10 . . . cord-015365-iqdi99pd 1558 1 -zufriedenheit -zufriedenheit : cord-015365-iqdi99pd 1558 2 : : : cord-015365-iqdi99pd 1559 1 wer wer NNP cord-015365-iqdi99pd 1560 1 lebt lebt NNP cord-015365-iqdi99pd 1560 2 länger länger NNP cord-015365-iqdi99pd 1560 3 , , , cord-015365-iqdi99pd 1560 4 wer wer NNP cord-015365-iqdi99pd 1560 5 lebt lebt NNP cord-015365-iqdi99pd 1560 6 besser besser NNP cord-015365-iqdi99pd 1560 7 ? ? . cord-015365-iqdi99pd 1561 1 Es Es NNP cord-015365-iqdi99pd 1561 2 werden werden NNP cord-015365-iqdi99pd 1561 3 klinisch klinisch NNP cord-015365-iqdi99pd 1561 4 - - HYPH cord-015365-iqdi99pd 1561 5 psychologische psychologische NNP cord-015365-iqdi99pd 1561 6 Studien Studien NNP cord-015365-iqdi99pd 1561 7 vorgestellt vorgestellt NNP cord-015365-iqdi99pd 1561 8 , , , cord-015365-iqdi99pd 1561 9 die die VB cord-015365-iqdi99pd 1561 10 belegen belegen NNP cord-015365-iqdi99pd 1561 11 , , , cord-015365-iqdi99pd 1561 12 dass dass NNP cord-015365-iqdi99pd 1561 13 ein ein NNP cord-015365-iqdi99pd 1561 14 bestimmtes bestimmtes NNPS cord-015365-iqdi99pd 1561 15 Persönlichkeitsmuster Persönlichkeitsmuster NNP cord-015365-iqdi99pd 1562 1 ( ( -LRB- cord-015365-iqdi99pd 1562 2 Typ Typ NNP cord-015365-iqdi99pd 1562 3 D D NNP cord-015365-iqdi99pd 1562 4 , , , cord-015365-iqdi99pd 1562 5 Denollet Denollet NNP cord-015365-iqdi99pd 1562 6 1996 1996 CD cord-015365-iqdi99pd 1562 7 ) ) -RRB- cord-015365-iqdi99pd 1563 1 Für Für NNP cord-015365-iqdi99pd 1563 2 die die VBP cord-015365-iqdi99pd 1563 3 drei drei NNS cord-015365-iqdi99pd 1563 4 am be VBP cord-015365-iqdi99pd 1564 1 häufigsten häufigsten NNP cord-015365-iqdi99pd 1564 2 durchgeführten durchgeführten NNP cord-015365-iqdi99pd 1564 3 pädiatrischen pädiatrischen NNP cord-015365-iqdi99pd 1564 4 Organtransplantationen Organtransplantationen NNP cord-015365-iqdi99pd 1565 1 ( ( -LRB- cord-015365-iqdi99pd 1565 2 Niere Niere NNP cord-015365-iqdi99pd 1565 3 , , , cord-015365-iqdi99pd 1565 4 Leber Leber NNP cord-015365-iqdi99pd 1565 5 , , , cord-015365-iqdi99pd 1565 6 Herz Herz NNP cord-015365-iqdi99pd 1565 7 ) ) -RRB- cord-015365-iqdi99pd 1565 8 wird wird NNP cord-015365-iqdi99pd 1565 9 der der NNP cord-015365-iqdi99pd 1565 10 jeweils jeweils NNP cord-015365-iqdi99pd 1565 11 aktuelle aktuelle NNP cord-015365-iqdi99pd 1565 12 Forschungsstand Forschungsstand NNP cord-015365-iqdi99pd 1565 13 referiert referiert NN cord-015365-iqdi99pd 1565 14 . . . cord-015365-iqdi99pd 1566 1 Darüber Darüber NNP cord-015365-iqdi99pd 1566 2 hinaus hinaus NNP cord-015365-iqdi99pd 1566 3 werden werden NNP cord-015365-iqdi99pd 1566 4 zwei zwei NNP cord-015365-iqdi99pd 1566 5 spezifische spezifische NNP cord-015365-iqdi99pd 1566 6 Problembereiche Problembereiche NNP cord-015365-iqdi99pd 1566 7 in in IN cord-015365-iqdi99pd 1566 8 der der NNP cord-015365-iqdi99pd 1566 9 pädiatrischen pädiatrischen NNP cord-015365-iqdi99pd 1566 10 Organtransplantation Organtransplantation NNP cord-015365-iqdi99pd 1566 11 dargestellt dargestellt NNP cord-015365-iqdi99pd 1566 12 , , , cord-015365-iqdi99pd 1567 1 das das NNP cord-015365-iqdi99pd 1567 2 Problem Problem NNP cord-015365-iqdi99pd 1567 3 der der NNP cord-015365-iqdi99pd 1567 4 Compliance Compliance NNP cord-015365-iqdi99pd 1567 5 / / SYM cord-015365-iqdi99pd 1567 6 Adherence Adherence NNP cord-015365-iqdi99pd 1567 7 und und NNP cord-015365-iqdi99pd 1568 1 der der NNP cord-015365-iqdi99pd 1568 2 Transition Transition NNP cord-015365-iqdi99pd 1568 3 von von NNP cord-015365-iqdi99pd 1568 4 der der NNP cord-015365-iqdi99pd 1568 5 Kinder Kinder NNP cord-015365-iqdi99pd 1568 6 - - HYPH cord-015365-iqdi99pd 1568 7 und und NNP cord-015365-iqdi99pd 1568 8 Jugendmedizin Jugendmedizin NNP cord-015365-iqdi99pd 1568 9 in in IN cord-015365-iqdi99pd 1568 10 die die JJ cord-015365-iqdi99pd 1568 11 Erwachsenenmedizin Erwachsenenmedizin NNP cord-015365-iqdi99pd 1568 12 . . . cord-015365-iqdi99pd 1569 1 Die die VB cord-015365-iqdi99pd 1569 2 Studien Studien NNP cord-015365-iqdi99pd 1569 3 unterscheiden unterscheiden JJ cord-015365-iqdi99pd 1569 4 sich sich NNP cord-015365-iqdi99pd 1569 5 hinsichtlich hinsichtlich NNP cord-015365-iqdi99pd 1569 6 der der NNP cord-015365-iqdi99pd 1569 7 Operationalisierung Operationalisierung NNP cord-015365-iqdi99pd 1569 8 der der NNP cord-015365-iqdi99pd 1569 9 LQ LQ NNP cord-015365-iqdi99pd 1569 10 , , , cord-015365-iqdi99pd 1569 11 des des NNP cord-015365-iqdi99pd 1569 12 Studiendesigns Studiendesigns NNP cord-015365-iqdi99pd 1569 13 , , , cord-015365-iqdi99pd 1569 14 der der NNP cord-015365-iqdi99pd 1569 15 Dauer Dauer NNP cord-015365-iqdi99pd 1569 16 des des FW cord-015365-iqdi99pd 1569 17 Follow follow NN cord-015365-iqdi99pd 1569 18 - - HYPH cord-015365-iqdi99pd 1569 19 ups up NNS cord-015365-iqdi99pd 1570 1 und und IN cord-015365-iqdi99pd 1570 2 des des NNP cord-015365-iqdi99pd 1570 3 Altersbereichs Altersbereichs NNP cord-015365-iqdi99pd 1570 4 der der NNP cord-015365-iqdi99pd 1570 5 Kinder Kinder NNP cord-015365-iqdi99pd 1570 6 . . . cord-015365-iqdi99pd 1571 1 Prospektive Prospektive NNP cord-015365-iqdi99pd 1571 2 Längsschnittstudien Längsschnittstudien NNP cord-015365-iqdi99pd 1571 3 mit mit VBD cord-015365-iqdi99pd 1571 4 größeren größeren NNP cord-015365-iqdi99pd 1571 5 Stichproben Stichproben NNP cord-015365-iqdi99pd 1571 6 in in IN cord-015365-iqdi99pd 1571 7 multizentrischer multizentrischer NNP cord-015365-iqdi99pd 1571 8 Zusammenarbeit Zusammenarbeit NNP cord-015365-iqdi99pd 1571 9 unter unter NNP cord-015365-iqdi99pd 1571 10 Einbeziehung Einbeziehung NNP cord-015365-iqdi99pd 1571 11 möglichst möglichst NNP cord-015365-iqdi99pd 1571 12 spezifischer spezifischer NNP cord-015365-iqdi99pd 1572 1 Erhebungsmethoden Erhebungsmethoden NNP cord-015365-iqdi99pd 1572 2 sind sind NNP cord-015365-iqdi99pd 1573 1 erforderlich erforderlich NNP cord-015365-iqdi99pd 1573 2 , , , cord-015365-iqdi99pd 1573 3 um um UH cord-015365-iqdi99pd 1573 4 die die VBP cord-015365-iqdi99pd 1573 5 postoperative postoperative JJ cord-015365-iqdi99pd 1573 6 Entwicklung Entwicklung NNP cord-015365-iqdi99pd 1573 7 der der NNP cord-015365-iqdi99pd 1573 8 Kinder Kinder NNP cord-015365-iqdi99pd 1573 9 besser besser NNP cord-015365-iqdi99pd 1573 10 beurteilen beurteilen VBN cord-015365-iqdi99pd 1573 11 zu zu NNP cord-015365-iqdi99pd 1573 12 können können NNP cord-015365-iqdi99pd 1573 13 . . . cord-015365-iqdi99pd 1574 1 Vor Vor NNP cord-015365-iqdi99pd 1574 2 dem dem NNP cord-015365-iqdi99pd 1574 3 Hintergrund Hintergrund NNP cord-015365-iqdi99pd 1574 4 einer einer NNP cord-015365-iqdi99pd 1575 1 neuen neuen NNP cord-015365-iqdi99pd 1575 2 Ä Ä NNP cord-015365-iqdi99pd 1575 3 ra ra NNP cord-015365-iqdi99pd 1576 1 der der NNP cord-015365-iqdi99pd 1576 2 immunsuppressiven immunsuppressiven NNP cord-015365-iqdi99pd 1576 3 Therapie Therapie NNP cord-015365-iqdi99pd 1576 4 ( ( -LRB- cord-015365-iqdi99pd 1576 5 Steroidminimierung Steroidminimierung NNP cord-015365-iqdi99pd 1576 6 , , , cord-015365-iqdi99pd 1576 7 individualisierte individualisierte NNS cord-015365-iqdi99pd 1576 8 Therapie Therapie NNP cord-015365-iqdi99pd 1576 9 ) ) -RRB- cord-015365-iqdi99pd 1577 1 kann kann NNP cord-015365-iqdi99pd 1577 2 hier hier NNP cord-015365-iqdi99pd 1577 3 zukünftig zukünftig NNP cord-015365-iqdi99pd 1578 1 eine eine NNP cord-015365-iqdi99pd 1579 1 weitere weitere NNP cord-015365-iqdi99pd 1579 2 Steigerung Steigerung NNP cord-015365-iqdi99pd 1579 3 der der NNP cord-015365-iqdi99pd 1580 1 LQ LQ NNP cord-015365-iqdi99pd 1580 2 erwartet erwartet NNP cord-015365-iqdi99pd 1580 3 werden werden NNP cord-015365-iqdi99pd 1580 4 . . . cord-015365-iqdi99pd 1581 1 Background background NN cord-015365-iqdi99pd 1581 2 . . . cord-015365-iqdi99pd 1582 1 Autologous autologous JJ cord-015365-iqdi99pd 1582 2 stem stem NN cord-015365-iqdi99pd 1582 3 cell cell NN cord-015365-iqdi99pd 1582 4 transplantation transplantation NN cord-015365-iqdi99pd 1582 5 ( ( -LRB- cord-015365-iqdi99pd 1582 6 ASCT ASCT NNP cord-015365-iqdi99pd 1582 7 ) ) -RRB- cord-015365-iqdi99pd 1582 8 is be VBZ cord-015365-iqdi99pd 1582 9 a a DT cord-015365-iqdi99pd 1582 10 curative curative JJ cord-015365-iqdi99pd 1582 11 procedure procedure NN cord-015365-iqdi99pd 1582 12 for for IN cord-015365-iqdi99pd 1582 13 a a DT cord-015365-iqdi99pd 1582 14 variety variety NN cord-015365-iqdi99pd 1582 15 of of IN cord-015365-iqdi99pd 1582 16 haemato haemato JJ cord-015365-iqdi99pd 1582 17 - - HYPH cord-015365-iqdi99pd 1582 18 oncological oncological JJ cord-015365-iqdi99pd 1582 19 malignancies malignancy NNS cord-015365-iqdi99pd 1582 20 and and CC cord-015365-iqdi99pd 1582 21 depends depend VBZ cord-015365-iqdi99pd 1582 22 on on IN cord-015365-iqdi99pd 1582 23 the the DT cord-015365-iqdi99pd 1582 24 transplantation transplantation NN cord-015365-iqdi99pd 1582 25 of of IN cord-015365-iqdi99pd 1582 26 sufficient sufficient JJ cord-015365-iqdi99pd 1582 27 CD34þ cd34þ NN cord-015365-iqdi99pd 1582 28 cells cell NNS cord-015365-iqdi99pd 1582 29 ( ( -LRB- cord-015365-iqdi99pd 1582 30 threshold threshold NN cord-015365-iqdi99pd 1582 31 of of IN cord-015365-iqdi99pd 1582 32 > > $ cord-015365-iqdi99pd 1582 33 2Â10 2â10 CD cord-015365-iqdi99pd 1582 34 6 6 CD cord-015365-iqdi99pd 1582 35 /kg /kg . cord-015365-iqdi99pd 1582 36 ) ) -RRB- cord-015365-iqdi99pd 1582 37 to to TO cord-015365-iqdi99pd 1582 38 ensure ensure VB cord-015365-iqdi99pd 1582 39 sustained sustain VBN cord-015365-iqdi99pd 1582 40 engraftment engraftment NN cord-015365-iqdi99pd 1582 41 . . . cord-015365-iqdi99pd 1583 1 In in IN cord-015365-iqdi99pd 1583 2 the the DT cord-015365-iqdi99pd 1583 3 last last JJ cord-015365-iqdi99pd 1583 4 decade decade NN cord-015365-iqdi99pd 1583 5 , , , cord-015365-iqdi99pd 1583 6 peripheral peripheral JJ cord-015365-iqdi99pd 1583 7 blood blood NN cord-015365-iqdi99pd 1583 8 stem stem NN cord-015365-iqdi99pd 1583 9 cells cell NNS cord-015365-iqdi99pd 1583 10 ( ( -LRB- cord-015365-iqdi99pd 1583 11 PBSC PBSC NNP cord-015365-iqdi99pd 1583 12 ) ) -RRB- cord-015365-iqdi99pd 1583 13 have have VBP cord-015365-iqdi99pd 1583 14 completely completely RB cord-015365-iqdi99pd 1583 15 replaced replace VBN cord-015365-iqdi99pd 1583 16 bone bone NN cord-015365-iqdi99pd 1583 17 marrow marrow NN cord-015365-iqdi99pd 1583 18 ( ( -LRB- cord-015365-iqdi99pd 1583 19 BM BM NNP cord-015365-iqdi99pd 1583 20 ) ) -RRB- cord-015365-iqdi99pd 1583 21 as as IN cord-015365-iqdi99pd 1583 22 preferred prefer VBN cord-015365-iqdi99pd 1583 23 stem stem NN cord-015365-iqdi99pd 1583 24 cell cell NN cord-015365-iqdi99pd 1583 25 graft graft NN cord-015365-iqdi99pd 1583 26 in in IN cord-015365-iqdi99pd 1583 27 ASCT ASCT NNP cord-015365-iqdi99pd 1583 28 . . . cord-015365-iqdi99pd 1584 1 However however RB cord-015365-iqdi99pd 1584 2 , , , cord-015365-iqdi99pd 1584 3 a a DT cord-015365-iqdi99pd 1584 4 number number NN cord-015365-iqdi99pd 1584 5 of of IN cord-015365-iqdi99pd 1584 6 patients patient NNS cord-015365-iqdi99pd 1584 7 fail fail VBP cord-015365-iqdi99pd 1584 8 to to TO cord-015365-iqdi99pd 1584 9 mobilize mobilize VB cord-015365-iqdi99pd 1584 10 the the DT cord-015365-iqdi99pd 1584 11 threshold threshold NN cord-015365-iqdi99pd 1584 12 of of IN cord-015365-iqdi99pd 1584 13 > > XX cord-015365-iqdi99pd 1585 1 2Â10 2â10 CD cord-015365-iqdi99pd 1585 2 6 6 CD cord-015365-iqdi99pd 1586 1 /kg /kg . cord-015365-iqdi99pd 1587 1 CD34þ cd34þ NN cord-015365-iqdi99pd 1587 2 cells cell NNS cord-015365-iqdi99pd 1587 3 . . . cord-015365-iqdi99pd 1588 1 In in IN cord-015365-iqdi99pd 1588 2 these these DT cord-015365-iqdi99pd 1588 3 poor poor JJ cord-015365-iqdi99pd 1588 4 mobilizers mobilizer NNS cord-015365-iqdi99pd 1588 5 , , , cord-015365-iqdi99pd 1588 6 BM BM NNP cord-015365-iqdi99pd 1588 7 harvest harvest NN cord-015365-iqdi99pd 1588 8 was be VBD cord-015365-iqdi99pd 1588 9 the the DT cord-015365-iqdi99pd 1588 10 only only JJ cord-015365-iqdi99pd 1588 11 possibility possibility NN cord-015365-iqdi99pd 1588 12 to to TO cord-015365-iqdi99pd 1588 13 collect collect VB cord-015365-iqdi99pd 1588 14 sufficient sufficient JJ cord-015365-iqdi99pd 1588 15 numbers number NNS cord-015365-iqdi99pd 1588 16 of of IN cord-015365-iqdi99pd 1588 17 stem stem NN cord-015365-iqdi99pd 1588 18 cells cell NNS cord-015365-iqdi99pd 1588 19 so so RB cord-015365-iqdi99pd 1588 20 far far RB cord-015365-iqdi99pd 1588 21 . . . cord-015365-iqdi99pd 1589 1 Recently recently RB cord-015365-iqdi99pd 1589 2 , , , cord-015365-iqdi99pd 1589 3 the the DT cord-015365-iqdi99pd 1589 4 chemokine chemokine NN cord-015365-iqdi99pd 1589 5 - - HYPH cord-015365-iqdi99pd 1589 6 receptor receptor NN cord-015365-iqdi99pd 1589 7 antagonist antagonist NN cord-015365-iqdi99pd 1589 8 plerixafor plerixafor NN cord-015365-iqdi99pd 1589 9 has have VBZ cord-015365-iqdi99pd 1589 10 shown show VBN cord-015365-iqdi99pd 1589 11 to to TO cord-015365-iqdi99pd 1589 12 enhance enhance VB cord-015365-iqdi99pd 1589 13 stem stem NN cord-015365-iqdi99pd 1589 14 cell cell NN cord-015365-iqdi99pd 1589 15 mobilization mobilization NN cord-015365-iqdi99pd 1589 16 in in IN cord-015365-iqdi99pd 1589 17 patients patient NNS cord-015365-iqdi99pd 1589 18 who who WP cord-015365-iqdi99pd 1589 19 demonstrated demonstrate VBD cord-015365-iqdi99pd 1589 20 with with IN cord-015365-iqdi99pd 1589 21 previous previous JJ cord-015365-iqdi99pd 1589 22 mobilization mobilization NN cord-015365-iqdi99pd 1589 23 failure failure NN cord-015365-iqdi99pd 1589 24 with with IN cord-015365-iqdi99pd 1589 25 an an DT cord-015365-iqdi99pd 1589 26 overall overall JJ cord-015365-iqdi99pd 1589 27 success success NN cord-015365-iqdi99pd 1589 28 rate rate NN cord-015365-iqdi99pd 1589 29 of of IN cord-015365-iqdi99pd 1589 30 about about RB cord-015365-iqdi99pd 1589 31 70 70 CD cord-015365-iqdi99pd 1589 32 % % NN cord-015365-iqdi99pd 1589 33 . . . cord-015365-iqdi99pd 1590 1 We -PRON- PRP cord-015365-iqdi99pd 1590 2 here here RB cord-015365-iqdi99pd 1590 3 report report VBP cord-015365-iqdi99pd 1590 4 4 4 CD cord-015365-iqdi99pd 1590 5 patients patient NNS cord-015365-iqdi99pd 1590 6 with with IN cord-015365-iqdi99pd 1590 7 mobilization mobilization NN cord-015365-iqdi99pd 1590 8 failure failure NN cord-015365-iqdi99pd 1590 9 in in IN cord-015365-iqdi99pd 1590 10 whom whom WP cord-015365-iqdi99pd 1590 11 G G NNP cord-015365-iqdi99pd 1590 12 - - HYPH cord-015365-iqdi99pd 1590 13 CSF CSF NNP cord-015365-iqdi99pd 1590 14 primed prime VBN cord-015365-iqdi99pd 1590 15 BM BM NNP cord-015365-iqdi99pd 1590 16 as as RB cord-015365-iqdi99pd 1590 17 well well RB cord-015365-iqdi99pd 1590 18 as as IN cord-015365-iqdi99pd 1590 19 plerixafor plerixafor NN cord-015365-iqdi99pd 1590 20 primed prime VBN cord-015365-iqdi99pd 1590 21 PBSC PBSC NNP cord-015365-iqdi99pd 1590 22 were be VBD cord-015365-iqdi99pd 1590 23 collected collect VBN cord-015365-iqdi99pd 1590 24 . . . cord-015365-iqdi99pd 1591 1 Methods method NNS cord-015365-iqdi99pd 1591 2 . . . cord-015365-iqdi99pd 1592 1 Four four CD cord-015365-iqdi99pd 1592 2 heavily heavily RB cord-015365-iqdi99pd 1592 3 pretreated pretreate VBN cord-015365-iqdi99pd 1592 4 patients patient NNS cord-015365-iqdi99pd 1592 5 ( ( -LRB- cord-015365-iqdi99pd 1592 6 median median NN cord-015365-iqdi99pd 1592 7 of of IN cord-015365-iqdi99pd 1592 8 10 10 CD cord-015365-iqdi99pd 1592 9 chemotherapy chemotherapy NN cord-015365-iqdi99pd 1592 10 cycles cycle NNS cord-015365-iqdi99pd 1592 11 , , , cord-015365-iqdi99pd 1592 12 range range VBP cord-015365-iqdi99pd 1592 13 8 8 CD cord-015365-iqdi99pd 1592 14 - - SYM cord-015365-iqdi99pd 1592 15 17 17 CD cord-015365-iqdi99pd 1592 16 ) ) -RRB- cord-015365-iqdi99pd 1592 17 with with IN cord-015365-iqdi99pd 1592 18 non non JJ cord-015365-iqdi99pd 1592 19 - - JJ cord-015365-iqdi99pd 1592 20 Hodgkin hodgkin JJ cord-015365-iqdi99pd 1592 21 lymphoma lymphoma NN cord-015365-iqdi99pd 1592 22 ( ( -LRB- cord-015365-iqdi99pd 1592 23 NHL NHL NNP cord-015365-iqdi99pd 1592 24 , , , cord-015365-iqdi99pd 1592 25 n n NN cord-015365-iqdi99pd 1592 26 ¼ ¼ NN cord-015365-iqdi99pd 1592 27 3 3 CD cord-015365-iqdi99pd 1592 28 . . . cord-015365-iqdi99pd 1592 29 ) ) -RRB- cord-015365-iqdi99pd 1592 30 and and CC cord-015365-iqdi99pd 1592 31 germ germ NN cord-015365-iqdi99pd 1592 32 cell cell NN cord-015365-iqdi99pd 1592 33 cancer cancer NN cord-015365-iqdi99pd 1592 34 ( ( -LRB- cord-015365-iqdi99pd 1592 35 n n NNP cord-015365-iqdi99pd 1592 36 ¼ ¼ NNP cord-015365-iqdi99pd 1592 37 1 1 CD cord-015365-iqdi99pd 1592 38 ) ) -RRB- cord-015365-iqdi99pd 1592 39 presented present VBN cord-015365-iqdi99pd 1592 40 with with IN cord-015365-iqdi99pd 1592 41 mobilization mobilization NN cord-015365-iqdi99pd 1592 42 failure failure NN cord-015365-iqdi99pd 1592 43 after after IN cord-015365-iqdi99pd 1592 44 1 1 CD cord-015365-iqdi99pd 1592 45 - - SYM cord-015365-iqdi99pd 1592 46 7 7 CD cord-015365-iqdi99pd 1592 47 mobilization mobilization NN cord-015365-iqdi99pd 1592 48 attempts attempt NNS cord-015365-iqdi99pd 1592 49 . . . cord-015365-iqdi99pd 1593 1 In in IN cord-015365-iqdi99pd 1593 2 the the DT cord-015365-iqdi99pd 1593 3 3 3 CD cord-015365-iqdi99pd 1593 4 NHL NHL NNP cord-015365-iqdi99pd 1593 5 patients patient NNS cord-015365-iqdi99pd 1593 6 BM BM NNP cord-015365-iqdi99pd 1593 7 was be VBD cord-015365-iqdi99pd 1593 8 harvested harvest VBN cord-015365-iqdi99pd 1593 9 after after IN cord-015365-iqdi99pd 1593 10 unsuccessful unsuccessful JJ cord-015365-iqdi99pd 1593 11 PBSC PBSC NNP cord-015365-iqdi99pd 1593 12 collection collection NN cord-015365-iqdi99pd 1593 13 with with IN cord-015365-iqdi99pd 1593 14 plerixafor plerixafor NN cord-015365-iqdi99pd 1593 15 . . . cord-015365-iqdi99pd 1594 1 In in IN cord-015365-iqdi99pd 1594 2 the the DT cord-015365-iqdi99pd 1594 3 patient patient NN cord-015365-iqdi99pd 1594 4 with with IN cord-015365-iqdi99pd 1594 5 germ germ NN cord-015365-iqdi99pd 1594 6 cell cell NN cord-015365-iqdi99pd 1594 7 tumor tumor NN cord-015365-iqdi99pd 1594 8 before before IN cord-015365-iqdi99pd 1594 9 plerixafor plerixafor NN cord-015365-iqdi99pd 1594 10 primed prime VBD cord-015365-iqdi99pd 1594 11 PBSC PBSC NNP cord-015365-iqdi99pd 1594 12 collection collection NN cord-015365-iqdi99pd 1594 13 was be VBD cord-015365-iqdi99pd 1594 14 done do VBN cord-015365-iqdi99pd 1594 15 after after IN cord-015365-iqdi99pd 1594 16 insufficient insufficient JJ cord-015365-iqdi99pd 1594 17 BM BM NNP cord-015365-iqdi99pd 1594 18 harvest harvest NN cord-015365-iqdi99pd 1594 19 . . . cord-015365-iqdi99pd 1595 1 Results result NNS cord-015365-iqdi99pd 1595 2 . . . cord-015365-iqdi99pd 1596 1 In in IN cord-015365-iqdi99pd 1596 2 the the DT cord-015365-iqdi99pd 1596 3 3 3 CD cord-015365-iqdi99pd 1596 4 NHL NHL NNP cord-015365-iqdi99pd 1596 5 patients patient NNS cord-015365-iqdi99pd 1596 6 plerixafor plerixafor NN cord-015365-iqdi99pd 1596 7 enhanced enhance VBN cord-015365-iqdi99pd 1596 8 PBSC PBSC NNP cord-015365-iqdi99pd 1596 9 revealed reveal VBD cord-015365-iqdi99pd 1596 10 an an DT cord-015365-iqdi99pd 1596 11 insufficient insufficient JJ cord-015365-iqdi99pd 1596 12 number number NN cord-015365-iqdi99pd 1596 13 of of IN cord-015365-iqdi99pd 1596 14 CD34þ cd34þ NN cord-015365-iqdi99pd 1596 15 cells cell NNS cord-015365-iqdi99pd 1596 16 ( ( -LRB- cord-015365-iqdi99pd 1596 17 i.e. i.e. FW cord-015365-iqdi99pd 1596 18 0.64- 0.64- CD cord-015365-iqdi99pd 1597 1 1.15Â10 1.15â10 CD cord-015365-iqdi99pd 1598 1 6 6 CD cord-015365-iqdi99pd 1599 1 /kg /kg . cord-015365-iqdi99pd 1600 1 CD34þ cd34þ NN cord-015365-iqdi99pd 1600 2 cells cell NNS cord-015365-iqdi99pd 1600 3 in in IN cord-015365-iqdi99pd 1600 4 2 2 CD cord-015365-iqdi99pd 1600 5 - - SYM cord-015365-iqdi99pd 1600 6 3 3 CD cord-015365-iqdi99pd 1600 7 leukaphereses leukapherese NNS cord-015365-iqdi99pd 1600 8 procedures procedure NNS cord-015365-iqdi99pd 1600 9 ) ) -RRB- cord-015365-iqdi99pd 1600 10 . . . cord-015365-iqdi99pd 1601 1 Therefore therefore RB cord-015365-iqdi99pd 1601 2 BM BM NNP cord-015365-iqdi99pd 1601 3 was be VBD cord-015365-iqdi99pd 1601 4 harvested harvest VBN cord-015365-iqdi99pd 1601 5 after after IN cord-015365-iqdi99pd 1601 6 G G NNP cord-015365-iqdi99pd 1601 7 - - HYPH cord-015365-iqdi99pd 1601 8 CSF csf NN cord-015365-iqdi99pd 1601 9 stimulation stimulation NN cord-015365-iqdi99pd 1601 10 . . . cord-015365-iqdi99pd 1602 1 However however RB cord-015365-iqdi99pd 1602 2 , , , cord-015365-iqdi99pd 1602 3 again again RB cord-015365-iqdi99pd 1602 4 we -PRON- PRP cord-015365-iqdi99pd 1602 5 failed fail VBD cord-015365-iqdi99pd 1602 6 to to TO cord-015365-iqdi99pd 1602 7 obtain obtain VB cord-015365-iqdi99pd 1602 8 enough enough JJ cord-015365-iqdi99pd 1602 9 CD34þ cd34þ NN cord-015365-iqdi99pd 1602 10 cells cell NNS cord-015365-iqdi99pd 1602 11 in in IN cord-015365-iqdi99pd 1602 12 all all DT cord-015365-iqdi99pd 1602 13 of of IN cord-015365-iqdi99pd 1602 14 them -PRON- PRP cord-015365-iqdi99pd 1602 15 ( ( -LRB- cord-015365-iqdi99pd 1602 16 0.16 0.16 CD cord-015365-iqdi99pd 1602 17 to to IN cord-015365-iqdi99pd 1602 18 0.62Â10 0.62â10 CD cord-015365-iqdi99pd 1602 19 6 6 CD cord-015365-iqdi99pd 1602 20 /kg /kg . cord-015365-iqdi99pd 1602 21 CD34þ cd34þ NN cord-015365-iqdi99pd 1602 22 cells cell NNS cord-015365-iqdi99pd 1602 23 ) ) -RRB- cord-015365-iqdi99pd 1602 24 . . . cord-015365-iqdi99pd 1603 1 In in IN cord-015365-iqdi99pd 1603 2 the the DT cord-015365-iqdi99pd 1603 3 patient patient NN cord-015365-iqdi99pd 1603 4 with with IN cord-015365-iqdi99pd 1603 5 germ germ NN cord-015365-iqdi99pd 1603 6 cell cell NN cord-015365-iqdi99pd 1603 7 cancer cancer NN cord-015365-iqdi99pd 1603 8 a a DT cord-015365-iqdi99pd 1603 9 collection collection NN cord-015365-iqdi99pd 1603 10 of of IN cord-015365-iqdi99pd 1603 11 CD34þ cd34þ NN cord-015365-iqdi99pd 1603 12 cells cell NNS cord-015365-iqdi99pd 1603 13 from from IN cord-015365-iqdi99pd 1603 14 the the DT cord-015365-iqdi99pd 1603 15 BM BM NNP cord-015365-iqdi99pd 1603 16 was be VBD cord-015365-iqdi99pd 1603 17 carried carry VBN cord-015365-iqdi99pd 1603 18 out out RP cord-015365-iqdi99pd 1603 19 as as IN cord-015365-iqdi99pd 1603 20 first first JJ cord-015365-iqdi99pd 1603 21 salvage salvage NN cord-015365-iqdi99pd 1603 22 procedure procedure NN cord-015365-iqdi99pd 1603 23 after after IN cord-015365-iqdi99pd 1603 24 the the DT cord-015365-iqdi99pd 1603 25 failure failure NN cord-015365-iqdi99pd 1603 26 of of IN cord-015365-iqdi99pd 1603 27 conventional conventional JJ cord-015365-iqdi99pd 1603 28 mobilization mobilization NN cord-015365-iqdi99pd 1603 29 ( ( -LRB- cord-015365-iqdi99pd 1603 30 0.9Â10 0.9â10 CD cord-015365-iqdi99pd 1603 31 6 6 CD cord-015365-iqdi99pd 1604 1 /kg /kg NFP cord-015365-iqdi99pd 1604 2 CD34þ cd34þ NN cord-015365-iqdi99pd 1604 3 cells cell NNS cord-015365-iqdi99pd 1604 4 ) ) -RRB- cord-015365-iqdi99pd 1604 5 . . . cord-015365-iqdi99pd 1605 1 Thus thus RB cord-015365-iqdi99pd 1605 2 , , , cord-015365-iqdi99pd 1605 3 in in IN cord-015365-iqdi99pd 1605 4 a a DT cord-015365-iqdi99pd 1605 5 next next JJ cord-015365-iqdi99pd 1605 6 attempt attempt NN cord-015365-iqdi99pd 1605 7 PBSCs pbsc NNS cord-015365-iqdi99pd 1605 8 were be VBD cord-015365-iqdi99pd 1605 9 mobilized mobilize VBN cord-015365-iqdi99pd 1605 10 with with IN cord-015365-iqdi99pd 1605 11 G G NNP cord-015365-iqdi99pd 1605 12 - - HYPH cord-015365-iqdi99pd 1605 13 CSF CSF NNP cord-015365-iqdi99pd 1605 14 and and CC cord-015365-iqdi99pd 1605 15 plerixafor plerixafor NN cord-015365-iqdi99pd 1605 16 resulting result VBG cord-015365-iqdi99pd 1605 17 in in IN cord-015365-iqdi99pd 1605 18 a a DT cord-015365-iqdi99pd 1605 19 successful successful JJ cord-015365-iqdi99pd 1605 20 harvest harvest NN cord-015365-iqdi99pd 1605 21 ( ( -LRB- cord-015365-iqdi99pd 1605 22 3.36Â10 3.36â10 CD cord-015365-iqdi99pd 1605 23 6 6 CD cord-015365-iqdi99pd 1605 24 /kg /kg NFP cord-015365-iqdi99pd 1605 25 CD34þ cd34þ NN cord-015365-iqdi99pd 1605 26 cells cell NNS cord-015365-iqdi99pd 1605 27 in in IN cord-015365-iqdi99pd 1605 28 one one CD cord-015365-iqdi99pd 1605 29 leukapheresis leukapheresis NN cord-015365-iqdi99pd 1605 30 ) ) -RRB- cord-015365-iqdi99pd 1605 31 . . . cord-015365-iqdi99pd 1606 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1606 2 . . . cord-015365-iqdi99pd 1607 1 Reviewing review VBG cord-015365-iqdi99pd 1607 2 our -PRON- PRP$ cord-015365-iqdi99pd 1607 3 cases case NNS cord-015365-iqdi99pd 1607 4 one one PRP cord-015365-iqdi99pd 1607 5 might may MD cord-015365-iqdi99pd 1607 6 speculate speculate VB cord-015365-iqdi99pd 1607 7 that that IN cord-015365-iqdi99pd 1607 8 a a DT cord-015365-iqdi99pd 1607 9 BM BM NNP cord-015365-iqdi99pd 1607 10 harvest harvest NN cord-015365-iqdi99pd 1607 11 after after IN cord-015365-iqdi99pd 1607 12 failure failure NN cord-015365-iqdi99pd 1607 13 of of IN cord-015365-iqdi99pd 1607 14 stem stem NN cord-015365-iqdi99pd 1607 15 cell cell NN cord-015365-iqdi99pd 1607 16 mobilization mobilization NN cord-015365-iqdi99pd 1607 17 with with IN cord-015365-iqdi99pd 1607 18 G G NNP cord-015365-iqdi99pd 1607 19 - - HYPH cord-015365-iqdi99pd 1607 20 CSF CSF NNP cord-015365-iqdi99pd 1607 21 and and CC cord-015365-iqdi99pd 1607 22 plerixafor plerixafor NN cord-015365-iqdi99pd 1607 23 does do VBZ cord-015365-iqdi99pd 1607 24 not not RB cord-015365-iqdi99pd 1607 25 yield yield VB cord-015365-iqdi99pd 1607 26 in in IN cord-015365-iqdi99pd 1607 27 sufficient sufficient JJ cord-015365-iqdi99pd 1607 28 CD34þ cd34þ NN cord-015365-iqdi99pd 1607 29 cell cell NN cord-015365-iqdi99pd 1607 30 numbers number NNS cord-015365-iqdi99pd 1607 31 . . . cord-015365-iqdi99pd 1608 1 Transient transient JJ cord-015365-iqdi99pd 1608 2 Elastography Elastography NNP cord-015365-iqdi99pd 1608 3 ( ( -LRB- cord-015365-iqdi99pd 1608 4 FibroScan FibroScan NNP cord-015365-iqdi99pd 1608 5 ) ) -RRB- cord-015365-iqdi99pd 1608 6 for for IN cord-015365-iqdi99pd 1608 7 the the DT cord-015365-iqdi99pd 1608 8 prediction prediction NN cord-015365-iqdi99pd 1608 9 of of IN cord-015365-iqdi99pd 1608 10 liver liver NN cord-015365-iqdi99pd 1608 11 toxicity toxicity NN cord-015365-iqdi99pd 1608 12 following follow VBG cord-015365-iqdi99pd 1608 13 autologous autologous JJ cord-015365-iqdi99pd 1608 14 or or CC cord-015365-iqdi99pd 1608 15 allogeneic allogeneic IN cord-015365-iqdi99pd 1608 16 HSCT HSCT NNP cord-015365-iqdi99pd 1608 17 J. J. NNP cord-015365-iqdi99pd 1608 18 Auberger Auberger NNP cord-015365-iqdi99pd 1608 19 1,2 1,2 CD cord-015365-iqdi99pd 1608 20 , , , cord-015365-iqdi99pd 1608 21 I. I. NNP cord-015365-iqdi99pd 1608 22 Graziadei Graziadei NNP cord-015365-iqdi99pd 1608 23 3 3 CD cord-015365-iqdi99pd 1608 24 , , , cord-015365-iqdi99pd 1608 25 W. W. NNP cord-015365-iqdi99pd 1608 26 Vogel Vogel NNP cord-015365-iqdi99pd 1608 27 3 3 CD cord-015365-iqdi99pd 1608 28 , , , cord-015365-iqdi99pd 1608 29 J. J. NNP cord-015365-iqdi99pd 1608 30 Clausen Clausen NNP cord-015365-iqdi99pd 1608 31 1,2 1,2 CD cord-015365-iqdi99pd 1608 32 , , , cord-015365-iqdi99pd 1608 33 D. D. NNP cord-015365-iqdi99pd 1608 34 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 1608 35 . . . cord-015365-iqdi99pd 1609 1 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1609 2 oder oder NN cord-015365-iqdi99pd 1609 3 das das NNP cord-015365-iqdi99pd 1609 4 Sinusoidale Sinusoidale NNP cord-015365-iqdi99pd 1609 5 Obstruktions Obstruktions NNP cord-015365-iqdi99pd 1609 6 - - HYPH cord-015365-iqdi99pd 1609 7 Syndrom Syndrom NNP cord-015365-iqdi99pd 1609 8 ( ( -LRB- cord-015365-iqdi99pd 1609 9 SOS SOS NNP cord-015365-iqdi99pd 1609 10 ) ) -RRB- cord-015365-iqdi99pd 1609 11 gehören gehören NNP cord-015365-iqdi99pd 1610 1 zu zu NNP cord-015365-iqdi99pd 1610 2 den den NNP cord-015365-iqdi99pd 1610 3 häufigsten häufigsten NNP cord-015365-iqdi99pd 1611 1 Organtoxizitäten Organtoxizitäten NNP cord-015365-iqdi99pd 1611 2 nach nach NNP cord-015365-iqdi99pd 1611 3 zytoreduktiver zytoreduktiver NNP cord-015365-iqdi99pd 1611 4 Hochdosis Hochdosis NNP cord-015365-iqdi99pd 1611 5 - - HYPH cord-015365-iqdi99pd 1611 6 Chemo-/Radiotherapie Chemo-/Radiotherapie NNP cord-015365-iqdi99pd 1611 7 bei bei NNP cord-015365-iqdi99pd 1611 8 autologer autologer NNP cord-015365-iqdi99pd 1611 9 oder oder NNP cord-015365-iqdi99pd 1611 10 allogener allogener NNP cord-015365-iqdi99pd 1611 11 HSCT HSCT NNP cord-015365-iqdi99pd 1611 12 . . . cord-015365-iqdi99pd 1612 1 Die die VB cord-015365-iqdi99pd 1612 2 transiente transiente NNP cord-015365-iqdi99pd 1613 1 Elastographie Elastographie NNP cord-015365-iqdi99pd 1614 1 ( ( -LRB- cord-015365-iqdi99pd 1614 2 Fibroscan Fibroscan NNP cord-015365-iqdi99pd 1614 3 , , , cord-015365-iqdi99pd 1614 4 FS FS NNP cord-015365-iqdi99pd 1614 5 ) ) -RRB- cord-015365-iqdi99pd 1614 6 ist ist NNP cord-015365-iqdi99pd 1614 7 eine eine NNP cord-015365-iqdi99pd 1614 8 neue neue NNP cord-015365-iqdi99pd 1614 9 , , , cord-015365-iqdi99pd 1614 10 schnell schnell NNP cord-015365-iqdi99pd 1614 11 zugängliche zugängliche NNP cord-015365-iqdi99pd 1614 12 und und IN cord-015365-iqdi99pd 1614 13 nicht nicht NNP cord-015365-iqdi99pd 1614 14 - - HYPH cord-015365-iqdi99pd 1614 15 invasive invasive JJ cord-015365-iqdi99pd 1614 16 Methode Methode NNP cord-015365-iqdi99pd 1614 17 eine eine NN cord-015365-iqdi99pd 1615 1 Leberfibrose Leberfibrose NNP cord-015365-iqdi99pd 1615 2 ü ü NN cord-015365-iqdi99pd 1616 1 ber ber NNP cord-015365-iqdi99pd 1616 2 die die NNP cord-015365-iqdi99pd 1617 1 Lebersteifigkeit Lebersteifigkeit NNP cord-015365-iqdi99pd 1618 1 ( ( -LRB- cord-015365-iqdi99pd 1618 2 LS LS NNP cord-015365-iqdi99pd 1618 3 ) ) -RRB- cord-015365-iqdi99pd 1618 4 zu zu NNP cord-015365-iqdi99pd 1618 5 bestimmen bestimmen NNP cord-015365-iqdi99pd 1619 1 und und NNP cord-015365-iqdi99pd 1619 2 wird wird NNP cord-015365-iqdi99pd 1619 3 bereits bereits NNP cord-015365-iqdi99pd 1619 4 erfolgreich erfolgreich NNP cord-015365-iqdi99pd 1619 5 bei bei NNP cord-015365-iqdi99pd 1619 6 Patienten Patienten NNP cord-015365-iqdi99pd 1619 7 mit mit NNP cord-015365-iqdi99pd 1619 8 Hepatitis Hepatitis NNP cord-015365-iqdi99pd 1619 9 C C NNP cord-015365-iqdi99pd 1619 10 und und NNP cord-015365-iqdi99pd 1620 1 alkoholischer alkoholischer NNP cord-015365-iqdi99pd 1620 2 Lebererkrankung Lebererkrankung NNP cord-015365-iqdi99pd 1620 3 eingesetzt eingesetzt VBD cord-015365-iqdi99pd 1620 4 . . . cord-015365-iqdi99pd 1621 1 Methodik Methodik NNP cord-015365-iqdi99pd 1621 2 . . . cord-015365-iqdi99pd 1622 1 Zwischen Zwischen NNP cord-015365-iqdi99pd 1622 2 April April NNP cord-015365-iqdi99pd 1622 3 2009 2009 CD cord-015365-iqdi99pd 1622 4 und und IN cord-015365-iqdi99pd 1622 5 Oktober Oktober NNP cord-015365-iqdi99pd 1622 6 2010 2010 CD cord-015365-iqdi99pd 1622 7 wurden wurden VBD cord-015365-iqdi99pd 1622 8 67 67 CD cord-015365-iqdi99pd 1622 9 Patienten Patienten NNP cord-015365-iqdi99pd 1622 10 FS FS NNP cord-015365-iqdi99pd 1622 11 - - HYPH cord-015365-iqdi99pd 1622 12 Messungen Messungen NNP cord-015365-iqdi99pd 1623 1 während während NNP cord-015365-iqdi99pd 1623 2 der der NNP cord-015365-iqdi99pd 1623 3 Routine Routine NNP cord-015365-iqdi99pd 1623 4 - - HYPH cord-015365-iqdi99pd 1623 5 Abdomensonographie Abdomensonographie NNP cord-015365-iqdi99pd 1624 1 i i PRP cord-015365-iqdi99pd 1625 1 m m NNP cord-015365-iqdi99pd 1625 2 Rahmen Rahmen NNP cord-015365-iqdi99pd 1626 1 der der NNP cord-015365-iqdi99pd 1626 2 Transplantvoruntersuchungen Transplantvoruntersuchungen NNP cord-015365-iqdi99pd 1627 1 vor vor NNP cord-015365-iqdi99pd 1627 2 autologer autologer NNP cord-015365-iqdi99pd 1627 3 ( ( -LRB- cord-015365-iqdi99pd 1627 4 n n NN cord-015365-iqdi99pd 1627 5 ¼ ¼ NNP cord-015365-iqdi99pd 1627 6 37 37 CD cord-015365-iqdi99pd 1627 7 ) ) -RRB- cord-015365-iqdi99pd 1627 8 oder oder NNP cord-015365-iqdi99pd 1627 9 allogener allogener NNP cord-015365-iqdi99pd 1627 10 ( ( -LRB- cord-015365-iqdi99pd 1627 11 n n NN cord-015365-iqdi99pd 1627 12 ¼ ¼ NNP cord-015365-iqdi99pd 1627 13 30 30 CD cord-015365-iqdi99pd 1627 14 ) ) -RRB- cord-015365-iqdi99pd 1627 15 Transplantation transplantation NN cord-015365-iqdi99pd 1627 16 zugeführt zugeführt NN cord-015365-iqdi99pd 1627 17 . . . cord-015365-iqdi99pd 1628 1 Die die VB cord-015365-iqdi99pd 1629 1 Konditionierung Konditionierung NNP cord-015365-iqdi99pd 1629 2 bestand bestand NNP cord-015365-iqdi99pd 1629 3 aus aus NNP cord-015365-iqdi99pd 1629 4 HD HD NNP cord-015365-iqdi99pd 1629 5 MEL MEL NNP cord-015365-iqdi99pd 1629 6 ( ( -LRB- cord-015365-iqdi99pd 1629 7 140 140 CD cord-015365-iqdi99pd 1629 8 - - SYM cord-015365-iqdi99pd 1629 9 200 200 CD cord-015365-iqdi99pd 1629 10 mg mg NNP cord-015365-iqdi99pd 1629 11 / / SYM cord-015365-iqdi99pd 1629 12 m m NNP cord-015365-iqdi99pd 1629 13 2 2 CD cord-015365-iqdi99pd 1629 14 ) ) -RRB- cord-015365-iqdi99pd 1629 15 , , . cord-015365-iqdi99pd 1630 1 BEAM BEAM NNP cord-015365-iqdi99pd 1630 2 oder oder NNP cord-015365-iqdi99pd 1630 3 anderen anderen NNP cord-015365-iqdi99pd 1631 1 krankheitsspezifischen krankheitsspezifischen NNP cord-015365-iqdi99pd 1631 2 Hochdosisschemata Hochdosisschemata NNP cord-015365-iqdi99pd 1632 1 i -PRON- PRP cord-015365-iqdi99pd 1632 2 m be VBP cord-015365-iqdi99pd 1632 3 Rahmen Rahmen NNP cord-015365-iqdi99pd 1632 4 autologer autologer NN cord-015365-iqdi99pd 1632 5 Transplantationen Transplantationen NNP cord-015365-iqdi99pd 1632 6 . . . cord-015365-iqdi99pd 1633 1 Allogene Allogene NNP cord-015365-iqdi99pd 1633 2 Transplantationen Transplantationen NNP cord-015365-iqdi99pd 1633 3 wurden wurden XX cord-015365-iqdi99pd 1633 4 nach nach NNP cord-015365-iqdi99pd 1633 5 myeloablativer myeloablativer NNP cord-015365-iqdi99pd 1633 6 Konditionierung Konditionierung NNP cord-015365-iqdi99pd 1633 7 ( ( -LRB- cord-015365-iqdi99pd 1633 8 MAC MAC NNP cord-015365-iqdi99pd 1633 9 , , , cord-015365-iqdi99pd 1633 10 n n NN cord-015365-iqdi99pd 1633 11 ¼ ¼ NNP cord-015365-iqdi99pd 1633 12 18 18 CD cord-015365-iqdi99pd 1633 13 ) ) -RRB- cord-015365-iqdi99pd 1633 14 oder oder NNP cord-015365-iqdi99pd 1633 15 in in IN cord-015365-iqdi99pd 1633 16 reduzierter reduzierter JJ cord-015365-iqdi99pd 1633 17 Intensität Intensität NNP cord-015365-iqdi99pd 1633 18 , , , cord-015365-iqdi99pd 1633 19 hauptsächlich hauptsächlich NN cord-015365-iqdi99pd 1633 20 BUFLU BUFLU NNP cord-015365-iqdi99pd 1633 21 basiert basiert NNP cord-015365-iqdi99pd 1633 22 ( ( -LRB- cord-015365-iqdi99pd 1633 23 RIC RIC NNP cord-015365-iqdi99pd 1633 24 , , , cord-015365-iqdi99pd 1633 25 n n NN cord-015365-iqdi99pd 1633 26 ¼ ¼ NNP cord-015365-iqdi99pd 1633 27 12 12 CD cord-015365-iqdi99pd 1633 28 ) ) -RRB- cord-015365-iqdi99pd 1633 29 durchgeführt durchgeführt NN cord-015365-iqdi99pd 1633 30 . . . cord-015365-iqdi99pd 1634 1 Die die VB cord-015365-iqdi99pd 1635 1 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1635 2 wurde wurde VBD cord-015365-iqdi99pd 1635 3 anhand anhand NNP cord-015365-iqdi99pd 1635 4 des des NNP cord-015365-iqdi99pd 1635 5 maximalen maximalen NNP cord-015365-iqdi99pd 1635 6 Serumbilirubins Serumbilirubins NNP cord-015365-iqdi99pd 1635 7 , , , cord-015365-iqdi99pd 1635 8 der der NNP cord-015365-iqdi99pd 1635 9 Anzahl Anzahl NNP cord-015365-iqdi99pd 1635 10 der der NNP cord-015365-iqdi99pd 1635 11 Tage Tage NNP cord-015365-iqdi99pd 1635 12 mit mit NNP cord-015365-iqdi99pd 1635 13 einem einem NNP cord-015365-iqdi99pd 1635 14 Bilirubin bilirubin NN cord-015365-iqdi99pd 1636 1 > > NFP cord-015365-iqdi99pd 1636 2 2 2 CD cord-015365-iqdi99pd 1636 3 mg mg NNP cord-015365-iqdi99pd 1636 4 / / SYM cord-015365-iqdi99pd 1636 5 dL dl NN cord-015365-iqdi99pd 1636 6 und und NNP cord-015365-iqdi99pd 1636 7 der der NNP cord-015365-iqdi99pd 1636 8 prozentualen prozentualen NNP cord-015365-iqdi99pd 1636 9 , , , cord-015365-iqdi99pd 1636 10 maximalen maximalen NNP cord-015365-iqdi99pd 1636 11 Gewichtszunahme Gewichtszunahme NNP cord-015365-iqdi99pd 1636 12 bis bis NNP cord-015365-iqdi99pd 1636 13 zum zum NNP cord-015365-iqdi99pd 1636 14 Tag tag NN cord-015365-iqdi99pd 1636 15 þ20 þ20 IN cord-015365-iqdi99pd 1636 16 definiert definiert NNP cord-015365-iqdi99pd 1636 17 . . . cord-015365-iqdi99pd 1637 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1637 2 . . . cord-015365-iqdi99pd 1638 1 Das Das NNP cord-015365-iqdi99pd 1638 2 maximale maximale NNP cord-015365-iqdi99pd 1638 3 Serum Serum NNP cord-015365-iqdi99pd 1638 4 Bilirubin bilirubin NN cord-015365-iqdi99pd 1638 5 vor vor NN cord-015365-iqdi99pd 1639 1 Tag tag NN cord-015365-iqdi99pd 1639 2 þ20 þ20 IN cord-015365-iqdi99pd 1639 3 betrug betrug NNP cord-015365-iqdi99pd 1639 4 1,18 1,18 CD cord-015365-iqdi99pd 1639 5 ( ( -LRB- cord-015365-iqdi99pd 1639 6 range range NN cord-015365-iqdi99pd 1639 7 , , , cord-015365-iqdi99pd 1639 8 0,44 0,44 CD cord-015365-iqdi99pd 1639 9 - - SYM cord-015365-iqdi99pd 1639 10 11,72 11,72 CD cord-015365-iqdi99pd 1639 11 ) ) -RRB- cord-015365-iqdi99pd 1640 1 mg mg NNP cord-015365-iqdi99pd 1640 2 / / SYM cord-015365-iqdi99pd 1640 3 dL dL NNP cord-015365-iqdi99pd 1640 4 , , , cord-015365-iqdi99pd 1640 5 der der NNP cord-015365-iqdi99pd 1640 6 mediane mediane NNP cord-015365-iqdi99pd 1640 7 Zeitpunkt Zeitpunkt NNP cord-015365-iqdi99pd 1640 8 mit mit NNP cord-015365-iqdi99pd 1640 9 einem einem NNP cord-015365-iqdi99pd 1640 10 Serumbilirubin Serumbilirubin NNP cord-015365-iqdi99pd 1640 11 ! ! . cord-015365-iqdi99pd 1641 1 2 2 LS cord-015365-iqdi99pd 1642 1 mg mg NNP cord-015365-iqdi99pd 1642 2 / / SYM cord-015365-iqdi99pd 1642 3 dL dl NN cord-015365-iqdi99pd 1642 4 war war NN cord-015365-iqdi99pd 1642 5 10,5 10,5 CD cord-015365-iqdi99pd 1643 1 ( ( -LRB- cord-015365-iqdi99pd 1643 2 range range NN cord-015365-iqdi99pd 1643 3 , , , cord-015365-iqdi99pd 1643 4 1 1 CD cord-015365-iqdi99pd 1643 5 - - SYM cord-015365-iqdi99pd 1643 6 20 20 CD cord-015365-iqdi99pd 1643 7 ) ) -RRB- cord-015365-iqdi99pd 1643 8 Tage tage NN cord-015365-iqdi99pd 1644 1 und und NNP cord-015365-iqdi99pd 1644 2 die die VB cord-015365-iqdi99pd 1644 3 mediane mediane NNP cord-015365-iqdi99pd 1644 4 prozentualen prozentualen NNP cord-015365-iqdi99pd 1644 5 Gewichtszunahme Gewichtszunahme NNP cord-015365-iqdi99pd 1644 6 war war NN cord-015365-iqdi99pd 1644 7 5,2 5,2 CD cord-015365-iqdi99pd 1644 8 % % NN cord-015365-iqdi99pd 1644 9 ( ( -LRB- cord-015365-iqdi99pd 1644 10 range range NN cord-015365-iqdi99pd 1644 11 , , , cord-015365-iqdi99pd 1644 12 0,1 0,1 CD cord-015365-iqdi99pd 1644 13 - - : cord-015365-iqdi99pd 1644 14 17,2 17,2 CD cord-015365-iqdi99pd 1644 15 ) ) -RRB- cord-015365-iqdi99pd 1644 16 . . . cord-015365-iqdi99pd 1645 1 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1645 2 wurde wurde VBD cord-015365-iqdi99pd 1645 3 häufiger häufiger NNP cord-015365-iqdi99pd 1645 4 nach nach NNP cord-015365-iqdi99pd 1645 5 MAC MAC NNP cord-015365-iqdi99pd 1645 6 vs. vs. FW cord-015365-iqdi99pd 1645 7 RIC RIC NNP cord-015365-iqdi99pd 1645 8 Konditionierung Konditionierung NNP cord-015365-iqdi99pd 1645 9 beobachtet beobachtet NNP cord-015365-iqdi99pd 1645 10 , , , cord-015365-iqdi99pd 1645 11 wenngleich wenngleich NNP cord-015365-iqdi99pd 1645 12 nicht nicht NNP cord-015365-iqdi99pd 1645 13 statistisch statistisch NNP cord-015365-iqdi99pd 1645 14 signifikant signifikant NNP cord-015365-iqdi99pd 1645 15 ( ( -LRB- cord-015365-iqdi99pd 1645 16 50 50 CD cord-015365-iqdi99pd 1645 17 % % NN cord-015365-iqdi99pd 1645 18 vs. vs. IN cord-015365-iqdi99pd 1645 19 33 33 CD cord-015365-iqdi99pd 1645 20 % % NN cord-015365-iqdi99pd 1645 21 , , , cord-015365-iqdi99pd 1645 22 p p NN cord-015365-iqdi99pd 1645 23 ¼ ¼ NNP cord-015365-iqdi99pd 1645 24 0,25 0,25 NNP cord-015365-iqdi99pd 1645 25 ) ) -RRB- cord-015365-iqdi99pd 1645 26 . . . cord-015365-iqdi99pd 1646 1 Patienten Patienten NNP cord-015365-iqdi99pd 1646 2 , , , cord-015365-iqdi99pd 1646 3 die die VB cord-015365-iqdi99pd 1646 4 eine eine JJ cord-015365-iqdi99pd 1646 5 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 1646 6 ( ( -LRB- cord-015365-iqdi99pd 1646 7 IS be VBZ cord-015365-iqdi99pd 1646 8 ) ) -RRB- cord-015365-iqdi99pd 1646 9 mit mit NNP cord-015365-iqdi99pd 1646 10 CsA CsA NNP cord-015365-iqdi99pd 1646 11 / / SYM cord-015365-iqdi99pd 1646 12 MTX MTX NNP cord-015365-iqdi99pd 1646 13 erhielten erhielten NNP cord-015365-iqdi99pd 1646 14 , , , cord-015365-iqdi99pd 1647 1 zeigten zeigten NNP cord-015365-iqdi99pd 1647 2 häufiger häufiger NNP cord-015365-iqdi99pd 1648 1 Anzeichen Anzeichen NNP cord-015365-iqdi99pd 1648 2 einer einer NNP cord-015365-iqdi99pd 1649 1 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1649 2 verglichen verglichen NNP cord-015365-iqdi99pd 1649 3 mit mit NNP cord-015365-iqdi99pd 1649 4 Pat Pat NNP cord-015365-iqdi99pd 1649 5 . . . cord-015365-iqdi99pd 1650 1 , , , cord-015365-iqdi99pd 1650 2 die die VB cord-015365-iqdi99pd 1651 1 CsA CsA NNP cord-015365-iqdi99pd 1651 2 / / SYM cord-015365-iqdi99pd 1651 3 MMF MMF NNP cord-015365-iqdi99pd 1652 1 oder oder NNP cord-015365-iqdi99pd 1652 2 keine keine NNP cord-015365-iqdi99pd 1652 3 IS be VBZ cord-015365-iqdi99pd 1652 4 erhielten erhielten NNP cord-015365-iqdi99pd 1652 5 ( ( -LRB- cord-015365-iqdi99pd 1652 6 83 83 CD cord-015365-iqdi99pd 1652 7 % % NN cord-015365-iqdi99pd 1652 8 vs. vs. IN cord-015365-iqdi99pd 1652 9 18 18 CD cord-015365-iqdi99pd 1652 10 % % NN cord-015365-iqdi99pd 1652 11 ) ) -RRB- cord-015365-iqdi99pd 1652 12 . . . cord-015365-iqdi99pd 1653 1 Die die VB cord-015365-iqdi99pd 1653 2 mediane mediane NNP cord-015365-iqdi99pd 1653 3 LS LS NNP cord-015365-iqdi99pd 1653 4 vor vor NN cord-015365-iqdi99pd 1654 1 Transplantation transplantation NN cord-015365-iqdi99pd 1654 2 war war NN cord-015365-iqdi99pd 1655 1 5,4 5,4 CD cord-015365-iqdi99pd 1656 1 kP kp XX cord-015365-iqdi99pd 1657 1 ( ( -LRB- cord-015365-iqdi99pd 1657 2 range range NN cord-015365-iqdi99pd 1657 3 , , , cord-015365-iqdi99pd 1657 4 2,3 2,3 CD cord-015365-iqdi99pd 1657 5 - - HYPH cord-015365-iqdi99pd 1657 6 62,7 62,7 CD cord-015365-iqdi99pd 1657 7 ) ) -RRB- cord-015365-iqdi99pd 1657 8 . . . cord-015365-iqdi99pd 1658 1 Die die VB cord-015365-iqdi99pd 1658 2 LS LS NNP cord-015365-iqdi99pd 1658 3 korrelierte korrelierte NNP cord-015365-iqdi99pd 1658 4 signifikant signifikant NNP cord-015365-iqdi99pd 1658 5 mit mit NNP cord-015365-iqdi99pd 1658 6 der der NNP cord-015365-iqdi99pd 1658 7 GOT get VBN cord-015365-iqdi99pd 1658 8 und und IN cord-015365-iqdi99pd 1658 9 GPT gpt NN cord-015365-iqdi99pd 1658 10 vor vor NN cord-015365-iqdi99pd 1658 11 Transplantation transplantation NN cord-015365-iqdi99pd 1658 12 in in IN cord-015365-iqdi99pd 1658 13 der der NNP cord-015365-iqdi99pd 1658 14 gesamten gesamten NNP cord-015365-iqdi99pd 1658 15 Kohorte Kohorte NNP cord-015365-iqdi99pd 1658 16 und und NNP cord-015365-iqdi99pd 1658 17 mit mit NNP cord-015365-iqdi99pd 1658 18 GPT GPT NNP cord-015365-iqdi99pd 1658 19 , , , cord-015365-iqdi99pd 1658 20 gGT gGT VBN cord-015365-iqdi99pd 1658 21 und und IN cord-015365-iqdi99pd 1658 22 AP AP NNP cord-015365-iqdi99pd 1658 23 bei bei NNP cord-015365-iqdi99pd 1658 24 Pat Pat NNP cord-015365-iqdi99pd 1658 25 . . . cord-015365-iqdi99pd 1659 1 mit mit NNP cord-015365-iqdi99pd 1659 2 mehr mehr JJ cord-015365-iqdi99pd 1659 3 als als NNP cord-015365-iqdi99pd 1659 4 10d 10d NNS cord-015365-iqdi99pd 1660 1 Bilirubin bilirubin NN cord-015365-iqdi99pd 1660 2 > > XX cord-015365-iqdi99pd 1661 1 2 2 CD cord-015365-iqdi99pd 1661 2 mg mg NNP cord-015365-iqdi99pd 1661 3 / / SYM cord-015365-iqdi99pd 1661 4 dl dl NN cord-015365-iqdi99pd 1661 5 bis bis NNP cord-015365-iqdi99pd 1661 6 zum zum NNP cord-015365-iqdi99pd 1661 7 Tag tag NN cord-015365-iqdi99pd 1661 8 þ þ NNP cord-015365-iqdi99pd 1662 1 20 20 CD cord-015365-iqdi99pd 1662 2 . . . cord-015365-iqdi99pd 1663 1 Zwischen Zwischen NNP cord-015365-iqdi99pd 1663 2 der der NNP cord-015365-iqdi99pd 1663 3 LS LS NNP cord-015365-iqdi99pd 1663 4 vor vor NN cord-015365-iqdi99pd 1663 5 HSCT HSCT NNP cord-015365-iqdi99pd 1663 6 und und IN cord-015365-iqdi99pd 1663 7 Zeichen Zeichen NNP cord-015365-iqdi99pd 1663 8 der der NNP cord-015365-iqdi99pd 1663 9 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1663 10 ( ( -LRB- cord-015365-iqdi99pd 1663 11 definiert definiert NNP cord-015365-iqdi99pd 1663 12 als als NNP cord-015365-iqdi99pd 1663 13 max max NNP cord-015365-iqdi99pd 1663 14 . . . cord-015365-iqdi99pd 1664 1 Serumbilirubin Serumbilirubin NNP cord-015365-iqdi99pd 1664 2 , , , cord-015365-iqdi99pd 1664 3 Anzahl Anzahl NNP cord-015365-iqdi99pd 1664 4 der der NNP cord-015365-iqdi99pd 1664 5 Tage Tage NNP cord-015365-iqdi99pd 1664 6 mit mit NNP cord-015365-iqdi99pd 1664 7 Bilirubin bilirubin NN cord-015365-iqdi99pd 1665 1 > > NFP cord-015365-iqdi99pd 1665 2 2 2 CD cord-015365-iqdi99pd 1665 3 mg mg NNP cord-015365-iqdi99pd 1665 4 / / SYM cord-015365-iqdi99pd 1665 5 dL dl NN cord-015365-iqdi99pd 1665 6 und und NNP cord-015365-iqdi99pd 1665 7 prozentualer prozentualer NNP cord-015365-iqdi99pd 1665 8 Gewichtszunahme Gewichtszunahme NNP cord-015365-iqdi99pd 1665 9 ) ) -RRB- cord-015365-iqdi99pd 1666 1 nach nach NNP cord-015365-iqdi99pd 1666 2 HSCT HSCT NNP cord-015365-iqdi99pd 1666 3 konnte konnte NNP cord-015365-iqdi99pd 1666 4 keine keine NNP cord-015365-iqdi99pd 1666 5 signifikante signifikante NNP cord-015365-iqdi99pd 1666 6 Korrelation Korrelation NNP cord-015365-iqdi99pd 1666 7 hergestellt hergestellt NNP cord-015365-iqdi99pd 1666 8 werden werden NNP cord-015365-iqdi99pd 1666 9 . . . cord-015365-iqdi99pd 1667 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 1667 2 . . . cord-015365-iqdi99pd 1668 1 Die die VB cord-015365-iqdi99pd 1668 2 nicht nicht NNP cord-015365-iqdi99pd 1668 3 - - HYPH cord-015365-iqdi99pd 1668 4 invasive invasive JJ cord-015365-iqdi99pd 1668 5 transiente transiente NNP cord-015365-iqdi99pd 1669 1 Elastographie Elastographie NNP cord-015365-iqdi99pd 1670 1 ( ( -LRB- cord-015365-iqdi99pd 1670 2 Fibroscan Fibroscan NNP cord-015365-iqdi99pd 1670 3 ) ) -RRB- cord-015365-iqdi99pd 1670 4 ist ist NNP cord-015365-iqdi99pd 1670 5 nicht nicht NNP cord-015365-iqdi99pd 1670 6 wegweisend wegweisend NNP cord-015365-iqdi99pd 1670 7 , , , cord-015365-iqdi99pd 1670 8 um um UH cord-015365-iqdi99pd 1670 9 Patienten Patienten NNP cord-015365-iqdi99pd 1670 10 zu zu NNP cord-015365-iqdi99pd 1670 11 identifizieren identifizieren NNP cord-015365-iqdi99pd 1670 12 , , , cord-015365-iqdi99pd 1670 13 die die VBP cord-015365-iqdi99pd 1670 14 ein ein NNP cord-015365-iqdi99pd 1670 15 hohes hohes NNP cord-015365-iqdi99pd 1670 16 Risiko Risiko NNP cord-015365-iqdi99pd 1670 17 für für NNS cord-015365-iqdi99pd 1670 18 die die VBP cord-015365-iqdi99pd 1670 19 Entwicklung Entwicklung NNP cord-015365-iqdi99pd 1670 20 einer einer NNP cord-015365-iqdi99pd 1671 1 Lebertoxizität Lebertoxizität NNP cord-015365-iqdi99pd 1671 2 nach nach VBP cord-015365-iqdi99pd 1671 3 autologer autologer NNP cord-015365-iqdi99pd 1671 4 oder oder NNP cord-015365-iqdi99pd 1671 5 allogener allogener NNP cord-015365-iqdi99pd 1671 6 Transplantation transplantation NN cord-015365-iqdi99pd 1671 7 aufweisen aufweisen NNP cord-015365-iqdi99pd 1671 8 . . . cord-015365-iqdi99pd 1672 1 Norovirus norovirus NN cord-015365-iqdi99pd 1672 2 associated associate VBN cord-015365-iqdi99pd 1672 3 hemophagocytic hemophagocytic JJ cord-015365-iqdi99pd 1672 4 lymphohistiocytosis lymphohistiocytosis NN cord-015365-iqdi99pd 1672 5 ( ( -LRB- cord-015365-iqdi99pd 1672 6 HLH HLH NNP cord-015365-iqdi99pd 1672 7 ) ) -RRB- cord-015365-iqdi99pd 1672 8 after after IN cord-015365-iqdi99pd 1672 9 unrelated unrelated JJ cord-015365-iqdi99pd 1672 10 bone bone NN cord-015365-iqdi99pd 1672 11 marrow marrow NN cord-015365-iqdi99pd 1672 12 transplantation transplantation NN cord-015365-iqdi99pd 1672 13 ( ( -LRB- cord-015365-iqdi99pd 1672 14 BMT BMT NNP cord-015365-iqdi99pd 1672 15 ) ) -RRB- cord-015365-iqdi99pd 1672 16 in in IN cord-015365-iqdi99pd 1672 17 a a DT cord-015365-iqdi99pd 1672 18 boy boy NN cord-015365-iqdi99pd 1672 19 with with IN cord-015365-iqdi99pd 1672 20 refractory refractory JJ cord-015365-iqdi99pd 1672 21 AML AML NNP cord-015365-iqdi99pd 1672 22 G. G. NNP cord-015365-iqdi99pd 1672 23 Kropshofer Kropshofer NNP cord-015365-iqdi99pd 1672 24 , , , cord-015365-iqdi99pd 1672 25 C. C. NNP cord-015365-iqdi99pd 1672 26 Salvador Salvador NNP cord-015365-iqdi99pd 1672 27 , , , cord-015365-iqdi99pd 1672 28 R. R. NNP cord-015365-iqdi99pd 1672 29 Crazzolara Crazzolara NNP cord-015365-iqdi99pd 1672 30 , , , cord-015365-iqdi99pd 1672 31 B. B. NNP cord-015365-iqdi99pd 1672 32 Meister Meister NNP cord-015365-iqdi99pd 1672 33 Background Background NNP cord-015365-iqdi99pd 1672 34 . . . cord-015365-iqdi99pd 1673 1 HLH HLH NNP cord-015365-iqdi99pd 1673 2 is be VBZ cord-015365-iqdi99pd 1673 3 a a DT cord-015365-iqdi99pd 1673 4 potentially potentially RB cord-015365-iqdi99pd 1673 5 life life NN cord-015365-iqdi99pd 1673 6 threatening threaten VBG cord-015365-iqdi99pd 1673 7 macrophage macrophage NN cord-015365-iqdi99pd 1673 8 activating activate VBG cord-015365-iqdi99pd 1673 9 syndrome syndrome NN cord-015365-iqdi99pd 1673 10 which which WDT cord-015365-iqdi99pd 1673 11 leads lead VBZ cord-015365-iqdi99pd 1673 12 to to IN cord-015365-iqdi99pd 1673 13 massive massive JJ cord-015365-iqdi99pd 1673 14 hyperinflammation hyperinflammation NN cord-015365-iqdi99pd 1673 15 through through IN cord-015365-iqdi99pd 1673 16 an an DT cord-015365-iqdi99pd 1673 17 exaggerated exaggerated JJ cord-015365-iqdi99pd 1673 18 but but CC cord-015365-iqdi99pd 1673 19 ineffective ineffective JJ cord-015365-iqdi99pd 1673 20 immune immune JJ cord-015365-iqdi99pd 1673 21 response response NN cord-015365-iqdi99pd 1673 22 . . . cord-015365-iqdi99pd 1674 1 Diagnosis diagnosis NN cord-015365-iqdi99pd 1674 2 after after IN cord-015365-iqdi99pd 1674 3 BMT BMT NNP cord-015365-iqdi99pd 1674 4 is be VBZ cord-015365-iqdi99pd 1674 5 complicated complicate VBN cord-015365-iqdi99pd 1674 6 by by IN cord-015365-iqdi99pd 1674 7 other other JJ cord-015365-iqdi99pd 1674 8 inflammatory inflammatory JJ cord-015365-iqdi99pd 1674 9 syndroms syndrom NNS cord-015365-iqdi99pd 1674 10 like like IN cord-015365-iqdi99pd 1674 11 engraftment engraftment NNP cord-015365-iqdi99pd 1674 12 syndrome syndrome NN cord-015365-iqdi99pd 1674 13 , , , cord-015365-iqdi99pd 1674 14 capillary capillary JJ cord-015365-iqdi99pd 1674 15 leak leak NN cord-015365-iqdi99pd 1674 16 syndrome syndrome NN cord-015365-iqdi99pd 1674 17 , , , cord-015365-iqdi99pd 1674 18 venoocclusive venoocclusive JJ cord-015365-iqdi99pd 1674 19 disease disease NN cord-015365-iqdi99pd 1674 20 and and CC cord-015365-iqdi99pd 1674 21 systemic systemic JJ cord-015365-iqdi99pd 1674 22 infections infection NNS cord-015365-iqdi99pd 1674 23 . . . cord-015365-iqdi99pd 1675 1 Methods method NNS cord-015365-iqdi99pd 1675 2 and and CC cord-015365-iqdi99pd 1675 3 Results result NNS cord-015365-iqdi99pd 1675 4 . . . cord-015365-iqdi99pd 1676 1 We -PRON- PRP cord-015365-iqdi99pd 1676 2 report report VBP cord-015365-iqdi99pd 1676 3 on on IN cord-015365-iqdi99pd 1676 4 a a DT cord-015365-iqdi99pd 1676 5 meanwhile meanwhile RB cord-015365-iqdi99pd 1676 6 24month 24month JJ cord-015365-iqdi99pd 1676 7 - - HYPH cord-015365-iqdi99pd 1676 8 old old JJ cord-015365-iqdi99pd 1676 9 boy boy NN cord-015365-iqdi99pd 1676 10 with with IN cord-015365-iqdi99pd 1676 11 AML AML NNP cord-015365-iqdi99pd 1676 12 ( ( -LRB- cord-015365-iqdi99pd 1676 13 M4 M4 NNP cord-015365-iqdi99pd 1676 14 ) ) -RRB- cord-015365-iqdi99pd 1676 15 relapse relapse NN cord-015365-iqdi99pd 1676 16 . . . cord-015365-iqdi99pd 1677 1 Already already RB cord-015365-iqdi99pd 1677 2 in in IN cord-015365-iqdi99pd 1677 3 phase phase NN cord-015365-iqdi99pd 1677 4 of of IN cord-015365-iqdi99pd 1677 5 maintenance maintenance NN cord-015365-iqdi99pd 1677 6 chemotherapy chemotherapy NN cord-015365-iqdi99pd 1677 7 he -PRON- PRP cord-015365-iqdi99pd 1677 8 acquired acquire VBD cord-015365-iqdi99pd 1677 9 a a DT cord-015365-iqdi99pd 1677 10 gastrointestinal gastrointestinal JJ cord-015365-iqdi99pd 1677 11 infection infection NN cord-015365-iqdi99pd 1677 12 with with IN cord-015365-iqdi99pd 1677 13 norovirus norovirus NN cord-015365-iqdi99pd 1677 14 . . . cord-015365-iqdi99pd 1678 1 Reinduction reinduction NN cord-015365-iqdi99pd 1678 2 chemotherapy chemotherapy NN cord-015365-iqdi99pd 1678 3 was be VBD cord-015365-iqdi99pd 1678 4 performed perform VBN cord-015365-iqdi99pd 1678 5 with with IN cord-015365-iqdi99pd 1678 6 FLAG FLAG NNP cord-015365-iqdi99pd 1678 7 / / SYM cord-015365-iqdi99pd 1678 8 Daunoxome Daunoxome NNP cord-015365-iqdi99pd 1678 9 and and CC cord-015365-iqdi99pd 1678 10 FLAMSA FLAMSA NNP cord-015365-iqdi99pd 1678 11 -he -he ADD cord-015365-iqdi99pd 1678 12 never never RB cord-015365-iqdi99pd 1678 13 reached reach VBD cord-015365-iqdi99pd 1678 14 a a DT cord-015365-iqdi99pd 1678 15 complete complete JJ cord-015365-iqdi99pd 1678 16 remission remission NN cord-015365-iqdi99pd 1678 17 . . . cord-015365-iqdi99pd 1679 1 So so RB cord-015365-iqdi99pd 1679 2 we -PRON- PRP cord-015365-iqdi99pd 1679 3 decided decide VBD cord-015365-iqdi99pd 1679 4 to to TO cord-015365-iqdi99pd 1679 5 perform perform VB cord-015365-iqdi99pd 1679 6 an an DT cord-015365-iqdi99pd 1679 7 allogeneic allogeneic NN cord-015365-iqdi99pd 1679 8 BMT BMT NNP cord-015365-iqdi99pd 1679 9 ( ( -LRB- cord-015365-iqdi99pd 1679 10 MUD MUD NNP cord-015365-iqdi99pd 1679 11 ) ) -RRB- cord-015365-iqdi99pd 1679 12 in in IN cord-015365-iqdi99pd 1679 13 aplasia aplasia NNP cord-015365-iqdi99pd 1679 14 . . . cord-015365-iqdi99pd 1680 1 Conditioning conditioning NN cord-015365-iqdi99pd 1680 2 regimen regimen NN cord-015365-iqdi99pd 1680 3 consisted consist VBD cord-015365-iqdi99pd 1680 4 of of IN cord-015365-iqdi99pd 1680 5 iv iv NNP cord-015365-iqdi99pd 1680 6 busulfan busulfan NNP cord-015365-iqdi99pd 1680 7 , , , cord-015365-iqdi99pd 1680 8 cyclophosphamide cyclophosphamide NN cord-015365-iqdi99pd 1680 9 and and CC cord-015365-iqdi99pd 1680 10 melphalan melphalan NNP cord-015365-iqdi99pd 1680 11 . . . cord-015365-iqdi99pd 1681 1 There there EX cord-015365-iqdi99pd 1681 2 were be VBD cord-015365-iqdi99pd 1681 3 no no DT cord-015365-iqdi99pd 1681 4 early early JJ cord-015365-iqdi99pd 1681 5 complications complication NNS cord-015365-iqdi99pd 1681 6 despite despite IN cord-015365-iqdi99pd 1681 7 his -PRON- PRP$ cord-015365-iqdi99pd 1681 8 ongoing ongoing JJ cord-015365-iqdi99pd 1681 9 norovirus norovirus NN cord-015365-iqdi99pd 1681 10 infection infection NN cord-015365-iqdi99pd 1681 11 . . . cord-015365-iqdi99pd 1682 1 Leukocyte Leukocyte NNP cord-015365-iqdi99pd 1682 2 engraftment engraftment NN cord-015365-iqdi99pd 1682 3 was be VBD cord-015365-iqdi99pd 1682 4 obtained obtain VBN cord-015365-iqdi99pd 1682 5 on on IN cord-015365-iqdi99pd 1682 6 day day NN cord-015365-iqdi99pd 1682 7 þ20 þ20 IN cord-015365-iqdi99pd 1682 8 . . . cord-015365-iqdi99pd 1683 1 Bone bone NN cord-015365-iqdi99pd 1683 2 marrow marrow NN cord-015365-iqdi99pd 1683 3 at at IN cord-015365-iqdi99pd 1683 4 day day NN cord-015365-iqdi99pd 1684 1 þ28 þ28 NNP cord-015365-iqdi99pd 1684 2 showed show VBD cord-015365-iqdi99pd 1684 3 a a DT cord-015365-iqdi99pd 1684 4 nearly nearly RB cord-015365-iqdi99pd 1684 5 normocellular normocellular JJ cord-015365-iqdi99pd 1684 6 bone bone NN cord-015365-iqdi99pd 1684 7 marrow marrow NN cord-015365-iqdi99pd 1684 8 and and CC cord-015365-iqdi99pd 1684 9 full full JJ cord-015365-iqdi99pd 1684 10 donor donor NN cord-015365-iqdi99pd 1684 11 chimerism chimerism NN cord-015365-iqdi99pd 1684 12 . . . cord-015365-iqdi99pd 1685 1 At at IN cord-015365-iqdi99pd 1685 2 day day NN cord-015365-iqdi99pd 1685 3 þ40 þ40 NNP cord-015365-iqdi99pd 1685 4 the the DT cord-015365-iqdi99pd 1685 5 patient patient NN cord-015365-iqdi99pd 1685 6 impressed impress VBN cord-015365-iqdi99pd 1685 7 with with IN cord-015365-iqdi99pd 1685 8 persistent persistent JJ cord-015365-iqdi99pd 1685 9 fever fever NN cord-015365-iqdi99pd 1685 10 despite despite IN cord-015365-iqdi99pd 1685 11 antimicrobial antimicrobial JJ cord-015365-iqdi99pd 1685 12 therapy therapy NN cord-015365-iqdi99pd 1685 13 , , , cord-015365-iqdi99pd 1685 14 his -PRON- PRP$ cord-015365-iqdi99pd 1685 15 general general JJ cord-015365-iqdi99pd 1685 16 status status NN cord-015365-iqdi99pd 1685 17 deteriorated deteriorate VBD cord-015365-iqdi99pd 1685 18 . . . cord-015365-iqdi99pd 1686 1 He -PRON- PRP cord-015365-iqdi99pd 1686 2 developed develop VBD cord-015365-iqdi99pd 1686 3 CNS CNS NNP cord-015365-iqdi99pd 1686 4 symptoms symptom NNS cord-015365-iqdi99pd 1686 5 with with IN cord-015365-iqdi99pd 1686 6 vertical vertical JJ cord-015365-iqdi99pd 1686 7 nystagmus nystagmus NN cord-015365-iqdi99pd 1686 8 , , , cord-015365-iqdi99pd 1686 9 increasing increase VBG cord-015365-iqdi99pd 1686 10 hepatosplenomegaly hepatosplenomegaly NNS cord-015365-iqdi99pd 1686 11 and and CC cord-015365-iqdi99pd 1686 12 respiratory respiratory JJ cord-015365-iqdi99pd 1686 13 insufficiency insufficiency NN cord-015365-iqdi99pd 1686 14 . . . cord-015365-iqdi99pd 1687 1 Laboratory laboratory NN cord-015365-iqdi99pd 1687 2 findings finding NNS cord-015365-iqdi99pd 1687 3 showed show VBD cord-015365-iqdi99pd 1687 4 hyperferritinemia hyperferritinemia NNP cord-015365-iqdi99pd 1687 5 ( ( -LRB- cord-015365-iqdi99pd 1687 6 45000 45000 CD cord-015365-iqdi99pd 1687 7 mg mg NNP cord-015365-iqdi99pd 1687 8 / / SYM cord-015365-iqdi99pd 1687 9 l l NNP cord-015365-iqdi99pd 1687 10 ) ) -RRB- cord-015365-iqdi99pd 1687 11 , , , cord-015365-iqdi99pd 1687 12 a a DT cord-015365-iqdi99pd 1687 13 subsequent subsequent JJ cord-015365-iqdi99pd 1687 14 pancytopenia pancytopenia NNP cord-015365-iqdi99pd 1687 15 , , , cord-015365-iqdi99pd 1687 16 hypofibrinogenemia hypofibrinogenemia NN cord-015365-iqdi99pd 1687 17 , , , cord-015365-iqdi99pd 1687 18 elevated elevated JJ cord-015365-iqdi99pd 1687 19 D D NNP cord-015365-iqdi99pd 1687 20 - - HYPH cord-015365-iqdi99pd 1687 21 Dimer Dimer NNP cord-015365-iqdi99pd 1687 22 ( ( -LRB- cord-015365-iqdi99pd 1687 23 34000 34000 CD cord-015365-iqdi99pd 1687 24 mg mg NNP cord-015365-iqdi99pd 1687 25 / / SYM cord-015365-iqdi99pd 1687 26 l l NNP cord-015365-iqdi99pd 1687 27 ) ) -RRB- cord-015365-iqdi99pd 1687 28 and and CC cord-015365-iqdi99pd 1687 29 hypertriglyceridemia hypertriglyceridemia NNP cord-015365-iqdi99pd 1687 30 ( ( -LRB- cord-015365-iqdi99pd 1687 31 723 723 CD cord-015365-iqdi99pd 1687 32 mg mg NNP cord-015365-iqdi99pd 1687 33 / / SYM cord-015365-iqdi99pd 1687 34 dl dl NNP cord-015365-iqdi99pd 1687 35 ) ) -RRB- cord-015365-iqdi99pd 1687 36 . . . cord-015365-iqdi99pd 1688 1 Intensive intensive JJ cord-015365-iqdi99pd 1688 2 care care NN cord-015365-iqdi99pd 1688 3 was be VBD cord-015365-iqdi99pd 1688 4 necessary necessary JJ cord-015365-iqdi99pd 1688 5 including include VBG cord-015365-iqdi99pd 1688 6 high high JJ cord-015365-iqdi99pd 1688 7 doses dose NNS cord-015365-iqdi99pd 1688 8 of of IN cord-015365-iqdi99pd 1688 9 catecholamines catecholamine NNS cord-015365-iqdi99pd 1688 10 . . . cord-015365-iqdi99pd 1689 1 Subsequent subsequent JJ cord-015365-iqdi99pd 1689 2 bone bone NN cord-015365-iqdi99pd 1689 3 marrow marrow NN cord-015365-iqdi99pd 1689 4 aspiration aspiration NN cord-015365-iqdi99pd 1689 5 revealed reveal VBD cord-015365-iqdi99pd 1689 6 an an DT cord-015365-iqdi99pd 1689 7 aplastic aplastic JJ cord-015365-iqdi99pd 1689 8 bone bone NN cord-015365-iqdi99pd 1689 9 marrow marrow NN cord-015365-iqdi99pd 1689 10 and and CC cord-015365-iqdi99pd 1689 11 hemophagocytosis hemophagocytosis NN cord-015365-iqdi99pd 1689 12 . . . cord-015365-iqdi99pd 1690 1 The the DT cord-015365-iqdi99pd 1690 2 patient patient NN cord-015365-iqdi99pd 1690 3 underwent undergo VBD cord-015365-iqdi99pd 1690 4 ventilation ventilation NN cord-015365-iqdi99pd 1690 5 support support NN cord-015365-iqdi99pd 1690 6 for for IN cord-015365-iqdi99pd 1690 7 17 17 CD cord-015365-iqdi99pd 1690 8 days day NNS cord-015365-iqdi99pd 1690 9 . . . cord-015365-iqdi99pd 1691 1 Treatment treatment NN cord-015365-iqdi99pd 1691 2 included include VBD cord-015365-iqdi99pd 1691 3 DXM DXM NNP cord-015365-iqdi99pd 1691 4 10 10 CD cord-015365-iqdi99pd 1692 1 mg mg NNP cord-015365-iqdi99pd 1692 2 / / SYM cord-015365-iqdi99pd 1692 3 m m NNP cord-015365-iqdi99pd 1693 1 2 2 LS cord-015365-iqdi99pd 1693 2 /d /d NN cord-015365-iqdi99pd 1693 3 for for IN cord-015365-iqdi99pd 1693 4 14 14 CD cord-015365-iqdi99pd 1693 5 days day NNS cord-015365-iqdi99pd 1694 1 , , , cord-015365-iqdi99pd 1694 2 then then RB cord-015365-iqdi99pd 1694 3 DXM DXM NNP cord-015365-iqdi99pd 1694 4 was be VBD cord-015365-iqdi99pd 1694 5 tapered taper VBN cord-015365-iqdi99pd 1694 6 to to IN cord-015365-iqdi99pd 1694 7 5 5 CD cord-015365-iqdi99pd 1694 8 mg mg NNP cord-015365-iqdi99pd 1694 9 / / SYM cord-015365-iqdi99pd 1694 10 kg kg NNP cord-015365-iqdi99pd 1694 11 / / SYM cord-015365-iqdi99pd 1694 12 d d NN cord-015365-iqdi99pd 1694 13 . . . cord-015365-iqdi99pd 1695 1 Etoposide Etoposide NNP cord-015365-iqdi99pd 1695 2 ( ( -LRB- cord-015365-iqdi99pd 1695 3 150 150 CD cord-015365-iqdi99pd 1695 4 mg mg NNP cord-015365-iqdi99pd 1695 5 / / SYM cord-015365-iqdi99pd 1695 6 kg kg NNP cord-015365-iqdi99pd 1695 7 ) ) -RRB- cord-015365-iqdi99pd 1695 8 was be VBD cord-015365-iqdi99pd 1695 9 given give VBN cord-015365-iqdi99pd 1695 10 three three CD cord-015365-iqdi99pd 1695 11 times time NNS cord-015365-iqdi99pd 1695 12 until until IN cord-015365-iqdi99pd 1695 13 now now RB cord-015365-iqdi99pd 1695 14 . . . cord-015365-iqdi99pd 1696 1 Considering consider VBG cord-015365-iqdi99pd 1696 2 the the DT cord-015365-iqdi99pd 1696 3 long long JJ cord-015365-iqdi99pd 1696 4 aplastic aplastic NN cord-015365-iqdi99pd 1696 5 phase phase NN cord-015365-iqdi99pd 1696 6 and and CC cord-015365-iqdi99pd 1696 7 the the DT cord-015365-iqdi99pd 1696 8 ongoing ongoing JJ cord-015365-iqdi99pd 1696 9 hemophagocytosis hemophagocytosis NN cord-015365-iqdi99pd 1696 10 we -PRON- PRP cord-015365-iqdi99pd 1696 11 decided decide VBD cord-015365-iqdi99pd 1696 12 to to TO cord-015365-iqdi99pd 1696 13 give give VB cord-015365-iqdi99pd 1696 14 him -PRON- PRP cord-015365-iqdi99pd 1696 15 stem stem NN cord-015365-iqdi99pd 1696 16 cell cell NN cord-015365-iqdi99pd 1696 17 support support NN cord-015365-iqdi99pd 1696 18 ( ( -LRB- cord-015365-iqdi99pd 1696 19 remaining remain VBG cord-015365-iqdi99pd 1696 20 frozen frozen JJ cord-015365-iqdi99pd 1696 21 bone bone NN cord-015365-iqdi99pd 1696 22 marrow marrow NN cord-015365-iqdi99pd 1696 23 from from IN cord-015365-iqdi99pd 1696 24 the the DT cord-015365-iqdi99pd 1696 25 same same JJ cord-015365-iqdi99pd 1696 26 donor donor NN cord-015365-iqdi99pd 1696 27 ) ) -RRB- cord-015365-iqdi99pd 1696 28 without without IN cord-015365-iqdi99pd 1696 29 reconditioning reconditioning NN cord-015365-iqdi99pd 1696 30 . . . cord-015365-iqdi99pd 1697 1 Four four CD cord-015365-iqdi99pd 1697 2 days day NNS cord-015365-iqdi99pd 1697 3 later later RB cord-015365-iqdi99pd 1697 4 we -PRON- PRP cord-015365-iqdi99pd 1697 5 went go VBD cord-015365-iqdi99pd 1697 6 on on RP cord-015365-iqdi99pd 1697 7 with with IN cord-015365-iqdi99pd 1697 8 a a DT cord-015365-iqdi99pd 1697 9 monoclonal monoclonal JJ cord-015365-iqdi99pd 1697 10 anti anti JJ cord-015365-iqdi99pd 1697 11 - - JJ cord-015365-iqdi99pd 1697 12 CD25 cd25 JJ cord-015365-iqdi99pd 1697 13 antibody antibody NN cord-015365-iqdi99pd 1697 14 ( ( -LRB- cord-015365-iqdi99pd 1697 15 Simulect Simulect NNP cord-015365-iqdi99pd 1697 16 + + CC cord-015365-iqdi99pd 1697 17 ) ) -RRB- cord-015365-iqdi99pd 1697 18 . . . cord-015365-iqdi99pd 1698 1 The the DT cord-015365-iqdi99pd 1698 2 boy boy NN cord-015365-iqdi99pd 1698 3 improved improve VBD cord-015365-iqdi99pd 1698 4 but but CC cord-015365-iqdi99pd 1698 5 therapy therapy NN cord-015365-iqdi99pd 1698 6 is be VBZ cord-015365-iqdi99pd 1698 7 still still RB cord-015365-iqdi99pd 1698 8 ongoing ongoing JJ cord-015365-iqdi99pd 1698 9 . . . cord-015365-iqdi99pd 1699 1 The the DT cord-015365-iqdi99pd 1699 2 outcome outcome NN cord-015365-iqdi99pd 1699 3 at at IN cord-015365-iqdi99pd 1699 4 the the DT cord-015365-iqdi99pd 1699 5 moment moment NN cord-015365-iqdi99pd 1699 6 is be VBZ cord-015365-iqdi99pd 1699 7 unclear unclear JJ cord-015365-iqdi99pd 1699 8 . . . cord-015365-iqdi99pd 1700 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1700 2 . . . cord-015365-iqdi99pd 1701 1 HLH HLH NNP cord-015365-iqdi99pd 1701 2 still still RB cord-015365-iqdi99pd 1701 3 is be VBZ cord-015365-iqdi99pd 1701 4 a a DT cord-015365-iqdi99pd 1701 5 rarely rarely RB cord-015365-iqdi99pd 1701 6 seen see VBN cord-015365-iqdi99pd 1701 7 complication complication NN cord-015365-iqdi99pd 1701 8 after after IN cord-015365-iqdi99pd 1701 9 BMT BMT NNP cord-015365-iqdi99pd 1701 10 , , , cord-015365-iqdi99pd 1701 11 therefore therefore RB cord-015365-iqdi99pd 1701 12 early early JJ cord-015365-iqdi99pd 1701 13 diagnosis diagnosis NN cord-015365-iqdi99pd 1701 14 is be VBZ cord-015365-iqdi99pd 1701 15 necessary necessary JJ cord-015365-iqdi99pd 1701 16 to to TO cord-015365-iqdi99pd 1701 17 start start VB cord-015365-iqdi99pd 1701 18 therapy therapy NN cord-015365-iqdi99pd 1701 19 promptly promptly RB cord-015365-iqdi99pd 1701 20 . . . cord-015365-iqdi99pd 1702 1 The the DT cord-015365-iqdi99pd 1702 2 role role NN cord-015365-iqdi99pd 1702 3 of of IN cord-015365-iqdi99pd 1702 4 monoclonal monoclonal JJ cord-015365-iqdi99pd 1702 5 anti anti JJ cord-015365-iqdi99pd 1702 6 - - JJ cord-015365-iqdi99pd 1702 7 CD25 cd25 JJ cord-015365-iqdi99pd 1702 8 antibody antibody NN cord-015365-iqdi99pd 1702 9 and and CC cord-015365-iqdi99pd 1702 10 anti anti NNP cord-015365-iqdi99pd 1702 11 TNF TNF NNP cord-015365-iqdi99pd 1702 12 - - HYPH cord-015365-iqdi99pd 1702 13 antibody antibody NN cord-015365-iqdi99pd 1702 14 as as IN cord-015365-iqdi99pd 1702 15 part part NN cord-015365-iqdi99pd 1702 16 of of IN cord-015365-iqdi99pd 1702 17 therapy therapy NN cord-015365-iqdi99pd 1702 18 is be VBZ cord-015365-iqdi99pd 1702 19 unclear unclear JJ cord-015365-iqdi99pd 1702 20 yet yet RB cord-015365-iqdi99pd 1702 21 . . . cord-015365-iqdi99pd 1703 1 Up up IN cord-015365-iqdi99pd 1703 2 to to IN cord-015365-iqdi99pd 1703 3 now now RB cord-015365-iqdi99pd 1703 4 there there EX cord-015365-iqdi99pd 1703 5 is be VBZ cord-015365-iqdi99pd 1703 6 no no DT cord-015365-iqdi99pd 1703 7 report report NN cord-015365-iqdi99pd 1703 8 of of IN cord-015365-iqdi99pd 1703 9 norovirus norovirus NN cord-015365-iqdi99pd 1703 10 triggering trigger VBG cord-015365-iqdi99pd 1703 11 HLH HLH NNP cord-015365-iqdi99pd 1703 12 . . . cord-015365-iqdi99pd 1704 1 Therapeutic therapeutic JJ cord-015365-iqdi99pd 1704 2 effect effect NN cord-015365-iqdi99pd 1704 3 of of IN cord-015365-iqdi99pd 1704 4 allogeneic allogeneic NN cord-015365-iqdi99pd 1704 5 bone bone NN cord-015365-iqdi99pd 1704 6 marrow marrow NN cord-015365-iqdi99pd 1704 7 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 1704 8 stem stem NN cord-015365-iqdi99pd 1704 9 cell cell NN cord-015365-iqdi99pd 1704 10 transplantation transplantation NN cord-015365-iqdi99pd 1704 11 on on IN cord-015365-iqdi99pd 1704 12 liver liver NN cord-015365-iqdi99pd 1704 13 chronic chronic JJ cord-015365-iqdi99pd 1704 14 damage damage NN cord-015365-iqdi99pd 1704 15 in in IN cord-015365-iqdi99pd 1704 16 rats rat NNS cord-015365-iqdi99pd 1704 17 Methods method NNS cord-015365-iqdi99pd 1704 18 . . . cord-015365-iqdi99pd 1705 1 75 75 CD cord-015365-iqdi99pd 1705 2 male male JJ cord-015365-iqdi99pd 1705 3 rats rat NNS cord-015365-iqdi99pd 1705 4 divided divide VBN cord-015365-iqdi99pd 1705 5 in in IN cord-015365-iqdi99pd 1705 6 3 3 CD cord-015365-iqdi99pd 1705 7 groups group NNS cord-015365-iqdi99pd 1705 8 in in IN cord-015365-iqdi99pd 1705 9 which which WDT cord-015365-iqdi99pd 1705 10 chronic chronic JJ cord-015365-iqdi99pd 1705 11 hepatitis hepatitis NN cord-015365-iqdi99pd 1705 12 was be VBD cord-015365-iqdi99pd 1705 13 modeled model VBN cord-015365-iqdi99pd 1705 14 by by IN cord-015365-iqdi99pd 1705 15 means mean NNS cord-015365-iqdi99pd 1705 16 of of IN cord-015365-iqdi99pd 1705 17 CCL CCL NNP cord-015365-iqdi99pd 1705 18 4 4 CD cord-015365-iqdi99pd 1705 19 . . . cord-015365-iqdi99pd 1706 1 1st 1st NN cord-015365-iqdi99pd 1707 1 ( ( -LRB- cord-015365-iqdi99pd 1707 2 n n NN cord-015365-iqdi99pd 1707 3 ¼ ¼ NNP cord-015365-iqdi99pd 1707 4 25 25 CD cord-015365-iqdi99pd 1707 5 ) ) -RRB- cord-015365-iqdi99pd 1707 6 received receive VBD cord-015365-iqdi99pd 1707 7 single single JJ cord-015365-iqdi99pd 1707 8 transplantation transplantation NN cord-015365-iqdi99pd 1707 9 of of IN cord-015365-iqdi99pd 1707 10 2.5Â10 2.5â10 CD cord-015365-iqdi99pd 1707 11 6 6 CD cord-015365-iqdi99pd 1707 12 MSC MSC NNP cord-015365-iqdi99pd 1707 13 on on IN cord-015365-iqdi99pd 1707 14 3rd 3rd JJ cord-015365-iqdi99pd 1707 15 day day NN cord-015365-iqdi99pd 1707 16 after after IN cord-015365-iqdi99pd 1707 17 modelling modelling NN cord-015365-iqdi99pd 1707 18 . . . cord-015365-iqdi99pd 1708 1 In in IN cord-015365-iqdi99pd 1708 2 2nd 2nd JJ cord-015365-iqdi99pd 1708 3 ( ( -LRB- cord-015365-iqdi99pd 1708 4 n n NN cord-015365-iqdi99pd 1708 5 ¼ ¼ NNP cord-015365-iqdi99pd 1708 6 25 25 CD cord-015365-iqdi99pd 1708 7 ) ) -RRB- cord-015365-iqdi99pd 1708 8 MSC MSC NNP cord-015365-iqdi99pd 1708 9 were be VBD cord-015365-iqdi99pd 1708 10 injected inject VBN cord-015365-iqdi99pd 1708 11 twice twice RB cord-015365-iqdi99pd 1708 12 in in IN cord-015365-iqdi99pd 1708 13 a a DT cord-015365-iqdi99pd 1708 14 dose dose NN cord-015365-iqdi99pd 1708 15 of of IN cord-015365-iqdi99pd 1708 16 2.5Â10 2.5â10 CD cord-015365-iqdi99pd 1708 17 6 6 CD cord-015365-iqdi99pd 1708 18 cells cell NNS cord-015365-iqdi99pd 1708 19 on on IN cord-015365-iqdi99pd 1708 20 days day NNS cord-015365-iqdi99pd 1708 21 3 3 CD cord-015365-iqdi99pd 1708 22 and and CC cord-015365-iqdi99pd 1708 23 10 10 CD cord-015365-iqdi99pd 1708 24 after after IN cord-015365-iqdi99pd 1708 25 modelling modelling NN cord-015365-iqdi99pd 1708 26 . . . cord-015365-iqdi99pd 1709 1 3rd 3rd NNP cord-015365-iqdi99pd 1709 2 group group NNP cord-015365-iqdi99pd 1709 3 was be VBD cord-015365-iqdi99pd 1709 4 control control NN cord-015365-iqdi99pd 1709 5 group group NN cord-015365-iqdi99pd 1709 6 ( ( -LRB- cord-015365-iqdi99pd 1709 7 CG CG NNP cord-015365-iqdi99pd 1709 8 , , , cord-015365-iqdi99pd 1709 9 n n NN cord-015365-iqdi99pd 1709 10 ¼ ¼ CD cord-015365-iqdi99pd 1709 11 25 25 CD cord-015365-iqdi99pd 1709 12 ) ) -RRB- cord-015365-iqdi99pd 1709 13 . . . cord-015365-iqdi99pd 1710 1 Biochemical biochemical JJ cord-015365-iqdi99pd 1710 2 indices index NNS cord-015365-iqdi99pd 1710 3 : : : cord-015365-iqdi99pd 1710 4 ALT ALT NNP cord-015365-iqdi99pd 1710 5 , , , cord-015365-iqdi99pd 1710 6 AST AST NNP cord-015365-iqdi99pd 1710 7 , , , cord-015365-iqdi99pd 1710 8 ALP ALP NNP cord-015365-iqdi99pd 1710 9 ; ; : cord-015365-iqdi99pd 1710 10 cytokines cytokine NNS cord-015365-iqdi99pd 1710 11 ( ( -LRB- cord-015365-iqdi99pd 1710 12 IFN- IFN- NNP cord-015365-iqdi99pd 1710 13 , , , cord-015365-iqdi99pd 1710 14 TNF- TNF- NNP cord-015365-iqdi99pd 1710 15 , , , cord-015365-iqdi99pd 1710 16 IL-4 IL-4 NNP cord-015365-iqdi99pd 1710 17 , , , cord-015365-iqdi99pd 1710 18 IL-10 IL-10 NNP cord-015365-iqdi99pd 1710 19 ) ) -RRB- cord-015365-iqdi99pd 1710 20 were be VBD cord-015365-iqdi99pd 1710 21 studied study VBN cord-015365-iqdi99pd 1710 22 during during IN cord-015365-iqdi99pd 1710 23 5 5 CD cord-015365-iqdi99pd 1710 24 weeks week NNS cord-015365-iqdi99pd 1710 25 . . . cord-015365-iqdi99pd 1711 1 Liver liver NN cord-015365-iqdi99pd 1711 2 histology histology NN cord-015365-iqdi99pd 1711 3 were be VBD cord-015365-iqdi99pd 1711 4 studied study VBN cord-015365-iqdi99pd 1711 5 after after IN cord-015365-iqdi99pd 1711 6 7 7 CD cord-015365-iqdi99pd 1711 7 , , , cord-015365-iqdi99pd 1711 8 14 14 CD cord-015365-iqdi99pd 1711 9 , , , cord-015365-iqdi99pd 1711 10 21 21 CD cord-015365-iqdi99pd 1711 11 , , , cord-015365-iqdi99pd 1711 12 28 28 CD cord-015365-iqdi99pd 1711 13 , , , cord-015365-iqdi99pd 1711 14 60 60 CD cord-015365-iqdi99pd 1711 15 , , , cord-015365-iqdi99pd 1711 16 90 90 CD cord-015365-iqdi99pd 1711 17 days day NNS cord-015365-iqdi99pd 1711 18 . . . cord-015365-iqdi99pd 1712 1 Immunohistochemical immunohistochemical JJ cord-015365-iqdi99pd 1712 2 methods method NNS cord-015365-iqdi99pd 1712 3 : : : cord-015365-iqdi99pd 1712 4 -SMA -sma ADD cord-015365-iqdi99pd 1712 5 , , , cord-015365-iqdi99pd 1712 6 caspase-3 caspase-3 NNP cord-015365-iqdi99pd 1712 7 , , , cord-015365-iqdi99pd 1712 8 AFP AFP NNP cord-015365-iqdi99pd 1712 9 and and CC cord-015365-iqdi99pd 1712 10 PCNA PCNA NNP cord-015365-iqdi99pd 1712 11 were be VBD cord-015365-iqdi99pd 1712 12 used use VBN cord-015365-iqdi99pd 1712 13 . . . cord-015365-iqdi99pd 1713 1 Results result NNS cord-015365-iqdi99pd 1713 2 . . . cord-015365-iqdi99pd 1714 1 At at IN cord-015365-iqdi99pd 1714 2 the the DT cord-015365-iqdi99pd 1714 3 1 1 CD cord-015365-iqdi99pd 1714 4 - - SYM cord-015365-iqdi99pd 1714 5 3 3 CD cord-015365-iqdi99pd 1714 6 weeks week NNS cord-015365-iqdi99pd 1714 7 the the DT cord-015365-iqdi99pd 1714 8 AST ast NN cord-015365-iqdi99pd 1714 9 , , , cord-015365-iqdi99pd 1714 10 ALT ALT NNP cord-015365-iqdi99pd 1714 11 and and CC cord-015365-iqdi99pd 1714 12 ALP ALP NNP cord-015365-iqdi99pd 1714 13 were be VBD cord-015365-iqdi99pd 1714 14 increased increase VBN cord-015365-iqdi99pd 1714 15 in in IN cord-015365-iqdi99pd 1714 16 all all DT cord-015365-iqdi99pd 1714 17 groups group NNS cord-015365-iqdi99pd 1714 18 , , , cord-015365-iqdi99pd 1714 19 but but CC cord-015365-iqdi99pd 1714 20 in in IN cord-015365-iqdi99pd 1714 21 the the DT cord-015365-iqdi99pd 1714 22 CG CG NNP cord-015365-iqdi99pd 1714 23 level level NN cord-015365-iqdi99pd 1714 24 of of IN cord-015365-iqdi99pd 1714 25 indices index NNS cord-015365-iqdi99pd 1714 26 above above RB cord-015365-iqdi99pd 1714 27 was be VBD cord-015365-iqdi99pd 1714 28 higher high JJR cord-015365-iqdi99pd 1714 29 . . . cord-015365-iqdi99pd 1715 1 Analysis analysis NN cord-015365-iqdi99pd 1715 2 of of IN cord-015365-iqdi99pd 1715 3 morphologic morphologic JJ cord-015365-iqdi99pd 1715 4 changes change NNS cord-015365-iqdi99pd 1715 5 in in IN cord-015365-iqdi99pd 1715 6 liver liver NN cord-015365-iqdi99pd 1715 7 resulted result VBN cord-015365-iqdi99pd 1715 8 in in IN cord-015365-iqdi99pd 1715 9 following follow VBG cord-015365-iqdi99pd 1715 10 findings finding NNS cord-015365-iqdi99pd 1715 11 : : : cord-015365-iqdi99pd 1715 12 on on IN cord-015365-iqdi99pd 1715 13 7th 7th JJ cord-015365-iqdi99pd 1715 14 and and CC cord-015365-iqdi99pd 1715 15 14th 14th JJ cord-015365-iqdi99pd 1715 16 day day NN cord-015365-iqdi99pd 1715 17 liver liver NN cord-015365-iqdi99pd 1715 18 fatty fatty JJ cord-015365-iqdi99pd 1715 19 degeneration degeneration NN cord-015365-iqdi99pd 1715 20 was be VBD cord-015365-iqdi99pd 1715 21 in in IN cord-015365-iqdi99pd 1715 22 all all DT cord-015365-iqdi99pd 1715 23 groups group NNS cord-015365-iqdi99pd 1715 24 , , , cord-015365-iqdi99pd 1715 25 but but CC cord-015365-iqdi99pd 1715 26 its -PRON- PRP$ cord-015365-iqdi99pd 1715 27 appearance appearance NN cord-015365-iqdi99pd 1715 28 was be VBD cord-015365-iqdi99pd 1715 29 stronger strong JJR cord-015365-iqdi99pd 1715 30 in in IN cord-015365-iqdi99pd 1715 31 the the DT cord-015365-iqdi99pd 1715 32 1st 1st NN cord-015365-iqdi99pd 1715 33 and and CC cord-015365-iqdi99pd 1715 34 especially especially RB cord-015365-iqdi99pd 1715 35 in in IN cord-015365-iqdi99pd 1715 36 CG CG NNP cord-015365-iqdi99pd 1715 37 . . . cord-015365-iqdi99pd 1716 1 In in IN cord-015365-iqdi99pd 1716 2 60 60 CD cord-015365-iqdi99pd 1716 3 and and CC cord-015365-iqdi99pd 1716 4 90 90 CD cord-015365-iqdi99pd 1716 5 days day NNS cord-015365-iqdi99pd 1716 6 the the DT cord-015365-iqdi99pd 1716 7 fibrosis fibrosis NN cord-015365-iqdi99pd 1716 8 became become VBD cord-015365-iqdi99pd 1716 9 more more RBR cord-015365-iqdi99pd 1716 10 severe severe JJ cord-015365-iqdi99pd 1716 11 in in IN cord-015365-iqdi99pd 1716 12 CG CG NNP cord-015365-iqdi99pd 1716 13 , , , cord-015365-iqdi99pd 1716 14 but but CC cord-015365-iqdi99pd 1716 15 after after IN cord-015365-iqdi99pd 1716 16 MSC MSC NNP cord-015365-iqdi99pd 1716 17 application application VBP cord-015365-iqdi99pd 1716 18 a a DT cord-015365-iqdi99pd 1716 19 resorption resorption NN cord-015365-iqdi99pd 1716 20 of of IN cord-015365-iqdi99pd 1716 21 fibrosis fibrosis NN cord-015365-iqdi99pd 1716 22 occurred occur VBD cord-015365-iqdi99pd 1716 23 ( ( -LRB- cord-015365-iqdi99pd 1716 24 especially especially RB cord-015365-iqdi99pd 1716 25 in in IN cord-015365-iqdi99pd 1716 26 2nd 2nd NN cord-015365-iqdi99pd 1716 27 ) ) -RRB- cord-015365-iqdi99pd 1716 28 . . . cord-015365-iqdi99pd 1717 1 It -PRON- PRP cord-015365-iqdi99pd 1717 2 is be VBZ cord-015365-iqdi99pd 1717 3 important important JJ cord-015365-iqdi99pd 1717 4 to to TO cord-015365-iqdi99pd 1717 5 note note VB cord-015365-iqdi99pd 1717 6 that that DT cord-015365-iqdi99pd 1717 7 connective connective JJ cord-015365-iqdi99pd 1717 8 tissue tissue NN cord-015365-iqdi99pd 1717 9 forming form VBG cord-015365-iqdi99pd 1717 10 in in IN cord-015365-iqdi99pd 1717 11 liver liver NN cord-015365-iqdi99pd 1717 12 after after IN cord-015365-iqdi99pd 1717 13 MSC MSC NNP cord-015365-iqdi99pd 1717 14 application application NN cord-015365-iqdi99pd 1717 15 had have VBD cord-015365-iqdi99pd 1717 16 two two CD cord-015365-iqdi99pd 1717 17 - - HYPH cord-015365-iqdi99pd 1717 18 phase phase NN cord-015365-iqdi99pd 1717 19 dynamics dynamic NNS cord-015365-iqdi99pd 1717 20 : : : cord-015365-iqdi99pd 1717 21 at at IN cord-015365-iqdi99pd 1717 22 first first RB cord-015365-iqdi99pd 1717 23 an an DT cord-015365-iqdi99pd 1717 24 area area NN cord-015365-iqdi99pd 1717 25 of of IN cord-015365-iqdi99pd 1717 26 connective connective JJ cord-015365-iqdi99pd 1717 27 tissue tissue NN cord-015365-iqdi99pd 1717 28 sharply sharply RB cord-015365-iqdi99pd 1717 29 increased increase VBD cord-015365-iqdi99pd 1717 30 and and CC cord-015365-iqdi99pd 1717 31 then then RB cord-015365-iqdi99pd 1717 32 gradually gradually RB cord-015365-iqdi99pd 1717 33 decreased decrease VBD cord-015365-iqdi99pd 1717 34 . . . cord-015365-iqdi99pd 1718 1 It -PRON- PRP cord-015365-iqdi99pd 1718 2 was be VBD cord-015365-iqdi99pd 1718 3 found find VBN cord-015365-iqdi99pd 1718 4 out out RP cord-015365-iqdi99pd 1718 5 that that IN cord-015365-iqdi99pd 1718 6 the the DT cord-015365-iqdi99pd 1718 7 -SMA -sma NN cord-015365-iqdi99pd 1718 8 and and CC cord-015365-iqdi99pd 1718 9 caspase caspase NN cord-015365-iqdi99pd 1718 10 3 3 CD cord-015365-iqdi99pd 1718 11 expression expression NN cord-015365-iqdi99pd 1718 12 after after IN cord-015365-iqdi99pd 1718 13 MSC MSC NNP cord-015365-iqdi99pd 1718 14 application application NN cord-015365-iqdi99pd 1718 15 had have VBD cord-015365-iqdi99pd 1718 16 also also RB cord-015365-iqdi99pd 1718 17 two two CD cord-015365-iqdi99pd 1718 18 - - HYPH cord-015365-iqdi99pd 1718 19 phase phase NN cord-015365-iqdi99pd 1718 20 dynamics dynamic NNS cord-015365-iqdi99pd 1718 21 : : : cord-015365-iqdi99pd 1718 22 at at IN cord-015365-iqdi99pd 1718 23 1 1 CD cord-015365-iqdi99pd 1718 24 - - SYM cord-015365-iqdi99pd 1718 25 2 2 CD cord-015365-iqdi99pd 1718 26 weeks week NNS cord-015365-iqdi99pd 1718 27 these these DT cord-015365-iqdi99pd 1718 28 indices index NNS cord-015365-iqdi99pd 1718 29 were be VBD cord-015365-iqdi99pd 1718 30 increased increase VBN cord-015365-iqdi99pd 1718 31 and and CC cord-015365-iqdi99pd 1718 32 then then RB cord-015365-iqdi99pd 1718 33 ( ( -LRB- cord-015365-iqdi99pd 1718 34 3 3 CD cord-015365-iqdi99pd 1718 35 - - SYM cord-015365-iqdi99pd 1718 36 4 4 CD cord-015365-iqdi99pd 1718 37 weeks week NNS cord-015365-iqdi99pd 1718 38 ) ) -RRB- cord-015365-iqdi99pd 1718 39 began begin VBD cord-015365-iqdi99pd 1718 40 to to TO cord-015365-iqdi99pd 1718 41 decrease decrease VB cord-015365-iqdi99pd 1718 42 , , , cord-015365-iqdi99pd 1718 43 becoming become VBG cord-015365-iqdi99pd 1718 44 lower low JJR cord-015365-iqdi99pd 1718 45 than than IN cord-015365-iqdi99pd 1718 46 in in IN cord-015365-iqdi99pd 1718 47 CG CG NNP cord-015365-iqdi99pd 1718 48 . . . cord-015365-iqdi99pd 1719 1 At at IN cord-015365-iqdi99pd 1719 2 first first JJ cord-015365-iqdi99pd 1719 3 weeks week NNS cord-015365-iqdi99pd 1719 4 cytokines cytokine NNS cord-015365-iqdi99pd 1719 5 disbalance disbalance NN cord-015365-iqdi99pd 1719 6 was be VBD cord-015365-iqdi99pd 1719 7 identified identify VBN cord-015365-iqdi99pd 1719 8 in in IN cord-015365-iqdi99pd 1719 9 all all DT cord-015365-iqdi99pd 1719 10 groups group NNS cord-015365-iqdi99pd 1719 11 , , , cord-015365-iqdi99pd 1719 12 but but CC cord-015365-iqdi99pd 1719 13 in in IN cord-015365-iqdi99pd 1719 14 MSC MSC NNP cord-015365-iqdi99pd 1719 15 groups group NNS cord-015365-iqdi99pd 1719 16 cytokines cytokine NNS cord-015365-iqdi99pd 1719 17 disbalance disbalance NN cord-015365-iqdi99pd 1719 18 was be VBD cord-015365-iqdi99pd 1719 19 less less RBR cord-015365-iqdi99pd 1719 20 expressed express VBN cord-015365-iqdi99pd 1719 21 on on IN cord-015365-iqdi99pd 1719 22 5th 5th JJ cord-015365-iqdi99pd 1719 23 week week NN cord-015365-iqdi99pd 1719 24 . . . cord-015365-iqdi99pd 1720 1 AFP AFP NNP cord-015365-iqdi99pd 1720 2 and and CC cord-015365-iqdi99pd 1720 3 PCNA PCNA NNP cord-015365-iqdi99pd 1720 4 expression expression NN cord-015365-iqdi99pd 1720 5 rates rate NNS cord-015365-iqdi99pd 1720 6 were be VBD cord-015365-iqdi99pd 1720 7 higher high JJR cord-015365-iqdi99pd 1720 8 in in IN cord-015365-iqdi99pd 1720 9 MSC MSC NNP cord-015365-iqdi99pd 1720 10 groups group NNS cord-015365-iqdi99pd 1720 11 , , , cord-015365-iqdi99pd 1720 12 than than IN cord-015365-iqdi99pd 1720 13 in in IN cord-015365-iqdi99pd 1720 14 CG CG NNP cord-015365-iqdi99pd 1720 15 up up RP cord-015365-iqdi99pd 1720 16 to to IN cord-015365-iqdi99pd 1720 17 end end NN cord-015365-iqdi99pd 1720 18 of of IN cord-015365-iqdi99pd 1720 19 examination examination NN cord-015365-iqdi99pd 1720 20 . . . cord-015365-iqdi99pd 1721 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1721 2 . . . cord-015365-iqdi99pd 1722 1 MSCs mscs JJ cord-015365-iqdi99pd 1722 2 transplantation transplantation NN cord-015365-iqdi99pd 1722 3 for for IN cord-015365-iqdi99pd 1722 4 therapy therapy NN cord-015365-iqdi99pd 1722 5 of of IN cord-015365-iqdi99pd 1722 6 liver liver NN cord-015365-iqdi99pd 1722 7 damage damage NN cord-015365-iqdi99pd 1722 8 can can MD cord-015365-iqdi99pd 1722 9 reduce reduce VB cord-015365-iqdi99pd 1722 10 liver liver NN cord-015365-iqdi99pd 1722 11 fibrosis fibrosis NN cord-015365-iqdi99pd 1722 12 , , , cord-015365-iqdi99pd 1722 13 but but CC cord-015365-iqdi99pd 1722 14 this this DT cord-015365-iqdi99pd 1722 15 process process NN cord-015365-iqdi99pd 1722 16 has have VBZ cord-015365-iqdi99pd 1722 17 two two CD cord-015365-iqdi99pd 1722 18 - - HYPH cord-015365-iqdi99pd 1722 19 phase phase NN cord-015365-iqdi99pd 1722 20 dynamics dynamic NNS cord-015365-iqdi99pd 1722 21 ( ( -LRB- cord-015365-iqdi99pd 1722 22 firstly firstly RB cord-015365-iqdi99pd 1722 23 increasing increase VBG cord-015365-iqdi99pd 1722 24 and and CC cord-015365-iqdi99pd 1722 25 then then RB cord-015365-iqdi99pd 1722 26 decreasing decrease VBG cord-015365-iqdi99pd 1722 27 of of IN cord-015365-iqdi99pd 1722 28 fibrosis fibrosis NN cord-015365-iqdi99pd 1722 29 ) ) -RRB- cord-015365-iqdi99pd 1722 30 which which WDT cord-015365-iqdi99pd 1722 31 can can MD cord-015365-iqdi99pd 1722 32 explain explain VB cord-015365-iqdi99pd 1722 33 the the DT cord-015365-iqdi99pd 1722 34 contradictory contradictory JJ cord-015365-iqdi99pd 1722 35 information information NN cord-015365-iqdi99pd 1722 36 on on IN cord-015365-iqdi99pd 1722 37 the the DT cord-015365-iqdi99pd 1722 38 cell cell NN cord-015365-iqdi99pd 1722 39 therapy therapy NN cord-015365-iqdi99pd 1722 40 of of IN cord-015365-iqdi99pd 1722 41 chronic chronic JJ cord-015365-iqdi99pd 1722 42 hepatitis hepatitis NNP cord-015365-iqdi99pd 1722 43 . . . cord-015365-iqdi99pd 1723 1 Background background NN cord-015365-iqdi99pd 1723 2 . . . cord-015365-iqdi99pd 1724 1 Treatment treatment NN cord-015365-iqdi99pd 1724 2 of of IN cord-015365-iqdi99pd 1724 3 chronic chronic JJ cord-015365-iqdi99pd 1724 4 liver liver NN cord-015365-iqdi99pd 1724 5 failure failure NN cord-015365-iqdi99pd 1724 6 in in IN cord-015365-iqdi99pd 1724 7 pretransplant pretransplant JJ cord-015365-iqdi99pd 1724 8 period period NN cord-015365-iqdi99pd 1724 9 is be VBZ cord-015365-iqdi99pd 1724 10 an an DT cord-015365-iqdi99pd 1724 11 actual actual JJ cord-015365-iqdi99pd 1724 12 problem problem NN cord-015365-iqdi99pd 1724 13 of of IN cord-015365-iqdi99pd 1724 14 medicine medicine NN cord-015365-iqdi99pd 1724 15 . . . cord-015365-iqdi99pd 1725 1 This this DT cord-015365-iqdi99pd 1725 2 investigation investigation NN cord-015365-iqdi99pd 1725 3 was be VBD cord-015365-iqdi99pd 1725 4 undertaken undertake VBN cord-015365-iqdi99pd 1725 5 for for IN cord-015365-iqdi99pd 1725 6 working work VBG cord-015365-iqdi99pd 1725 7 out out IN cord-015365-iqdi99pd 1725 8 of of IN cord-015365-iqdi99pd 1725 9 biounit biounit NNP cord-015365-iqdi99pd 1725 10 containing contain VBG cord-015365-iqdi99pd 1725 11 viable viable JJ cord-015365-iqdi99pd 1725 12 liver liver NN cord-015365-iqdi99pd 1725 13 cell cell NN cord-015365-iqdi99pd 1725 14 ( ( -LRB- cord-015365-iqdi99pd 1725 15 LC LC NNP cord-015365-iqdi99pd 1725 16 ) ) -RRB- cord-015365-iqdi99pd 1725 17 and and CC cord-015365-iqdi99pd 1725 18 multipotent multipotent JJ cord-015365-iqdi99pd 1725 19 mesenchymal mesenchymal JJ cord-015365-iqdi99pd 1725 20 stromal stromal NN cord-015365-iqdi99pd 1725 21 cells cell NNS cord-015365-iqdi99pd 1725 22 ( ( -LRB- cord-015365-iqdi99pd 1725 23 MMSC MMSC NNP cord-015365-iqdi99pd 1725 24 ) ) -RRB- cord-015365-iqdi99pd 1725 25 , , , cord-015365-iqdi99pd 1725 26 which which WDT cord-015365-iqdi99pd 1725 27 could could MD cord-015365-iqdi99pd 1725 28 support support VB cord-015365-iqdi99pd 1725 29 the the DT cord-015365-iqdi99pd 1725 30 functioning function VBG cord-015365-iqdi99pd 1725 31 and and CC cord-015365-iqdi99pd 1725 32 recovered recover VBD cord-015365-iqdi99pd 1725 33 regeneration regeneration NN cord-015365-iqdi99pd 1725 34 of of IN cord-015365-iqdi99pd 1725 35 damaged damaged JJ cord-015365-iqdi99pd 1725 36 liver liver NN cord-015365-iqdi99pd 1725 37 for for IN cord-015365-iqdi99pd 1725 38 a a DT cord-015365-iqdi99pd 1725 39 long long JJ cord-015365-iqdi99pd 1725 40 time time NN cord-015365-iqdi99pd 1725 41 . . . cord-015365-iqdi99pd 1726 1 Methods method NNS cord-015365-iqdi99pd 1726 2 . . . cord-015365-iqdi99pd 1727 1 Chronic chronic JJ cord-015365-iqdi99pd 1727 2 liver liver NN cord-015365-iqdi99pd 1727 3 damage damage NN cord-015365-iqdi99pd 1727 4 was be VBD cord-015365-iqdi99pd 1727 5 modeled model VBN cord-015365-iqdi99pd 1727 6 on on IN cord-015365-iqdi99pd 1727 7 Wistar Wistar NNP cord-015365-iqdi99pd 1727 8 rats rat NNS cord-015365-iqdi99pd 1727 9 by by IN cord-015365-iqdi99pd 1727 10 means mean NNS cord-015365-iqdi99pd 1727 11 of of IN cord-015365-iqdi99pd 1727 12 0.3 0.3 CD cord-015365-iqdi99pd 1727 13 ml ml NN cord-015365-iqdi99pd 1727 14 CCl CCl NNS cord-015365-iqdi99pd 1727 15 4 4 CD cord-015365-iqdi99pd 1727 16 on on IN cord-015365-iqdi99pd 1727 17 100 100 CD cord-015365-iqdi99pd 1727 18 g g NN cord-015365-iqdi99pd 1727 19 rat rat NN cord-015365-iqdi99pd 1727 20 weights weight NNS cord-015365-iqdi99pd 1727 21 within within IN cord-015365-iqdi99pd 1727 22 6 6 CD cord-015365-iqdi99pd 1727 23 weeks week NNS cord-015365-iqdi99pd 1727 24 . . . cord-015365-iqdi99pd 1728 1 Adult Adult NNP cord-015365-iqdi99pd 1728 2 Wistar Wistar NNP cord-015365-iqdi99pd 1728 3 rats rat NNS cord-015365-iqdi99pd 1728 4 were be VBD cord-015365-iqdi99pd 1728 5 also also RB cord-015365-iqdi99pd 1728 6 used use VBN cord-015365-iqdi99pd 1728 7 as as IN cord-015365-iqdi99pd 1728 8 donor donor NN cord-015365-iqdi99pd 1728 9 cells cell NNS cord-015365-iqdi99pd 1728 10 . . . cord-015365-iqdi99pd 1729 1 Isolated isolated JJ cord-015365-iqdi99pd 1729 2 cells cell NNS cord-015365-iqdi99pd 1729 3 were be VBD cord-015365-iqdi99pd 1729 4 cultivated cultivate VBN cord-015365-iqdi99pd 1729 5 in in IN cord-015365-iqdi99pd 1729 6 10 10 CD cord-015365-iqdi99pd 1729 7 days day NNS cord-015365-iqdi99pd 1729 8 : : : cord-015365-iqdi99pd 1729 9 at at IN cord-015365-iqdi99pd 1729 10 first first JJ cord-015365-iqdi99pd 1729 11 MMSC MMSC NNP cord-015365-iqdi99pd 1729 12 during during IN cord-015365-iqdi99pd 1729 13 7 7 CD cord-015365-iqdi99pd 1729 14 days day NNS cord-015365-iqdi99pd 1729 15 then then RB cord-015365-iqdi99pd 1729 16 the the DT cord-015365-iqdi99pd 1729 17 same same JJ cord-015365-iqdi99pd 1729 18 MMSC MMSC NNP cord-015365-iqdi99pd 1729 19 together together RB cord-015365-iqdi99pd 1729 20 with with IN cord-015365-iqdi99pd 1729 21 LC LC NNP cord-015365-iqdi99pd 1729 22 in in IN cord-015365-iqdi99pd 1729 23 3 3 CD cord-015365-iqdi99pd 1729 24 days day NNS cord-015365-iqdi99pd 1729 25 on on IN cord-015365-iqdi99pd 1729 26 Cytodex Cytodex NNP cord-015365-iqdi99pd 1729 27 . . . cord-015365-iqdi99pd 1730 1 Suspension suspension NN cord-015365-iqdi99pd 1730 2 of of IN cord-015365-iqdi99pd 1730 3 LC LC NNP cord-015365-iqdi99pd 1730 4 2.5 2.5 CD cord-015365-iqdi99pd 1730 5 - - HYPH cord-015365-iqdi99pd 1730 6 4.0Â10 4.0â10 CD cord-015365-iqdi99pd 1730 7 6 6 CD cord-015365-iqdi99pd 1730 8 cells cell NNS cord-015365-iqdi99pd 1730 9 / / SYM cord-015365-iqdi99pd 1730 10 cm cm NN cord-015365-iqdi99pd 1730 11 3 3 CD cord-015365-iqdi99pd 1730 12 and and CC cord-015365-iqdi99pd 1730 13 MMSC MMSC NNP cord-015365-iqdi99pd 1730 14 0.5 0.5 CD cord-015365-iqdi99pd 1730 15 - - HYPH cord-015365-iqdi99pd 1730 16 0.8Â10 0.8â10 CD cord-015365-iqdi99pd 1730 17 6 6 CD cord-015365-iqdi99pd 1730 18 cells/ cells/ CD cord-015365-iqdi99pd 1730 19 cm cm NNP cord-015365-iqdi99pd 1730 20 3 3 CD cord-015365-iqdi99pd 1730 21 was be VBD cord-015365-iqdi99pd 1730 22 applied apply VBN cord-015365-iqdi99pd 1730 23 on on IN cord-015365-iqdi99pd 1730 24 biodegradable biodegradable JJ cord-015365-iqdi99pd 1730 25 matrixes matrix NNS cord-015365-iqdi99pd 1730 26 " " `` cord-015365-iqdi99pd 1730 27 Sphero Sphero NNP cord-015365-iqdi99pd 1730 28 + + SYM cord-015365-iqdi99pd 1730 29 Gel gel NN cord-015365-iqdi99pd 1730 30 " " '' cord-015365-iqdi99pd 1730 31 . . . cord-015365-iqdi99pd 1731 1 Formed form VBN cord-015365-iqdi99pd 1731 2 biounits biounit NNS cord-015365-iqdi99pd 1731 3 were be VBD cord-015365-iqdi99pd 1731 4 transplantated transplantate VBN cord-015365-iqdi99pd 1731 5 into into IN cord-015365-iqdi99pd 1731 6 rat rat NN cord-015365-iqdi99pd 1731 7 liver liver NN cord-015365-iqdi99pd 1731 8 . . . cord-015365-iqdi99pd 1732 1 Survival survival NN cord-015365-iqdi99pd 1732 2 of of IN cord-015365-iqdi99pd 1732 3 transplanted transplanted JJ cord-015365-iqdi99pd 1732 4 cells cell NNS cord-015365-iqdi99pd 1732 5 and and CC cord-015365-iqdi99pd 1732 6 liver liver NN cord-015365-iqdi99pd 1732 7 morphology morphology NN cord-015365-iqdi99pd 1732 8 were be VBD cord-015365-iqdi99pd 1732 9 investigated investigate VBN cord-015365-iqdi99pd 1732 10 in in IN cord-015365-iqdi99pd 1732 11 365 365 CD cord-015365-iqdi99pd 1732 12 days day NNS cord-015365-iqdi99pd 1732 13 after after IN cord-015365-iqdi99pd 1732 14 transplantation transplantation NN cord-015365-iqdi99pd 1732 15 by by IN cord-015365-iqdi99pd 1732 16 using use VBG cord-015365-iqdi99pd 1732 17 hematoxylin hematoxylin NNP cord-015365-iqdi99pd 1732 18 and and CC cord-015365-iqdi99pd 1732 19 eosin eosin NN cord-015365-iqdi99pd 1732 20 staining staining NN cord-015365-iqdi99pd 1732 21 , , , cord-015365-iqdi99pd 1732 22 Masson Masson NNP cord-015365-iqdi99pd 1732 23 's 's POS cord-015365-iqdi99pd 1732 24 trichrome trichrome JJ cord-015365-iqdi99pd 1732 25 staining staining NN cord-015365-iqdi99pd 1732 26 . . . cord-015365-iqdi99pd 1733 1 Cell cell NN cord-015365-iqdi99pd 1733 2 viability viability NN cord-015365-iqdi99pd 1733 3 and and CC cord-015365-iqdi99pd 1733 4 cellular cellular JJ cord-015365-iqdi99pd 1733 5 phenotype phenotype NN cord-015365-iqdi99pd 1733 6 were be VBD cord-015365-iqdi99pd 1733 7 investigated investigate VBN cord-015365-iqdi99pd 1733 8 by by IN cord-015365-iqdi99pd 1733 9 trypan trypan NNP cord-015365-iqdi99pd 1733 10 blue blue JJ cord-015365-iqdi99pd 1733 11 staining staining NN cord-015365-iqdi99pd 1733 12 and and CC cord-015365-iqdi99pd 1733 13 immunohistochemically immunohistochemically NN cord-015365-iqdi99pd 1733 14 ( ( -LRB- cord-015365-iqdi99pd 1733 15 cytokeratine cytokeratine NNP cord-015365-iqdi99pd 1733 16 18 18 CD cord-015365-iqdi99pd 1733 17 and and CC cord-015365-iqdi99pd 1733 18 mitochondrial mitochondrial JJ cord-015365-iqdi99pd 1733 19 antigen antigen NN cord-015365-iqdi99pd 1733 20 ) ) -RRB- cord-015365-iqdi99pd 1733 21 . . . cord-015365-iqdi99pd 1734 1 Results result NNS cord-015365-iqdi99pd 1734 2 . . . cord-015365-iqdi99pd 1735 1 Before before IN cord-015365-iqdi99pd 1735 2 biounit biounit VBN cord-015365-iqdi99pd 1735 3 transplantation transplantation NN cord-015365-iqdi99pd 1735 4 liver liver NN cord-015365-iqdi99pd 1735 5 damage damage NN cord-015365-iqdi99pd 1735 6 was be VBD cord-015365-iqdi99pd 1735 7 characterized characterize VBN cord-015365-iqdi99pd 1735 8 by by IN cord-015365-iqdi99pd 1735 9 : : : cord-015365-iqdi99pd 1735 10 fatty fatty JJ cord-015365-iqdi99pd 1735 11 , , , cord-015365-iqdi99pd 1735 12 lymphoid lymphoid JJ cord-015365-iqdi99pd 1735 13 - - HYPH cord-015365-iqdi99pd 1735 14 cellular cellular JJ cord-015365-iqdi99pd 1735 15 infiltration infiltration NN cord-015365-iqdi99pd 1735 16 and and CC cord-015365-iqdi99pd 1735 17 proliferation proliferation NN cord-015365-iqdi99pd 1735 18 of of IN cord-015365-iqdi99pd 1735 19 histioblasts histioblast NNS cord-015365-iqdi99pd 1735 20 and and CC cord-015365-iqdi99pd 1735 21 macrophages macrophage NNS cord-015365-iqdi99pd 1735 22 ; ; : cord-015365-iqdi99pd 1735 23 porto porto NNP cord-015365-iqdi99pd 1735 24 - - HYPH cord-015365-iqdi99pd 1735 25 portal portal JJ cord-015365-iqdi99pd 1735 26 sclerosis sclerosis NN cord-015365-iqdi99pd 1735 27 ; ; : cord-015365-iqdi99pd 1735 28 hydropic hydropic NNP cord-015365-iqdi99pd 1735 29 dystrophia dystrophia NNP cord-015365-iqdi99pd 1735 30 and and CC cord-015365-iqdi99pd 1735 31 focal focal JJ cord-015365-iqdi99pd 1735 32 necrosis necrosis NN cord-015365-iqdi99pd 1735 33 of of IN cord-015365-iqdi99pd 1735 34 hepatocytes hepatocyte NNS cord-015365-iqdi99pd 1735 35 . . . cord-015365-iqdi99pd 1736 1 In in IN cord-015365-iqdi99pd 1736 2 365 365 CD cord-015365-iqdi99pd 1736 3 days day NNS cord-015365-iqdi99pd 1736 4 after after IN cord-015365-iqdi99pd 1736 5 biounit biounit NNP cord-015365-iqdi99pd 1736 6 transplantation transplantation NN cord-015365-iqdi99pd 1736 7 it -PRON- PRP cord-015365-iqdi99pd 1736 8 was be VBD cord-015365-iqdi99pd 1736 9 detected detect VBN cord-015365-iqdi99pd 1736 10 : : : cord-015365-iqdi99pd 1736 11 viable viable JJ cord-015365-iqdi99pd 1736 12 hepatocytes hepatocyte NNS cord-015365-iqdi99pd 1736 13 , , , cord-015365-iqdi99pd 1736 14 neogenic neogenic NNP cord-015365-iqdi99pd 1736 15 plethoric plethoric NNP cord-015365-iqdi99pd 1736 16 vessels vessel NNS cord-015365-iqdi99pd 1736 17 , , , cord-015365-iqdi99pd 1736 18 neogenic neogenic NNP cord-015365-iqdi99pd 1736 19 plethoric plethoric NNP cord-015365-iqdi99pd 1736 20 bile bile NN cord-015365-iqdi99pd 1736 21 duct duct NN cord-015365-iqdi99pd 1736 22 in in IN cord-015365-iqdi99pd 1736 23 biounit biounit NNP cord-015365-iqdi99pd 1736 24 . . . cord-015365-iqdi99pd 1737 1 Liver liver NN cord-015365-iqdi99pd 1737 2 damage damage NN cord-015365-iqdi99pd 1737 3 ( ( -LRB- cord-015365-iqdi99pd 1737 4 dystrophia dystrophia NNP cord-015365-iqdi99pd 1737 5 , , , cord-015365-iqdi99pd 1737 6 safe safe JJ cord-015365-iqdi99pd 1737 7 structure structure NN cord-015365-iqdi99pd 1737 8 of of IN cord-015365-iqdi99pd 1737 9 a a DT cord-015365-iqdi99pd 1737 10 liver liver NN cord-015365-iqdi99pd 1737 11 , , , cord-015365-iqdi99pd 1737 12 beam beam NN cord-015365-iqdi99pd 1737 13 structure structure NN cord-015365-iqdi99pd 1737 14 , , , cord-015365-iqdi99pd 1737 15 fatty fatty JJ cord-015365-iqdi99pd 1737 16 vacuoles vacuole NNS cord-015365-iqdi99pd 1737 17 inside inside IN cord-015365-iqdi99pd 1737 18 hepatocytes hepatocyte NNS cord-015365-iqdi99pd 1737 19 and and CC cord-015365-iqdi99pd 1737 20 other other JJ cord-015365-iqdi99pd 1737 21 indices index NNS cord-015365-iqdi99pd 1737 22 ) ) -RRB- cord-015365-iqdi99pd 1737 23 were be VBD cord-015365-iqdi99pd 1737 24 significant significant JJ cord-015365-iqdi99pd 1737 25 less less RBR cord-015365-iqdi99pd 1737 26 after after IN cord-015365-iqdi99pd 1737 27 biounit biounit VBN cord-015365-iqdi99pd 1737 28 transplantation transplantation NN cord-015365-iqdi99pd 1737 29 than than IN cord-015365-iqdi99pd 1737 30 in in IN cord-015365-iqdi99pd 1737 31 control control NN cord-015365-iqdi99pd 1737 32 group group NN cord-015365-iqdi99pd 1737 33 without without IN cord-015365-iqdi99pd 1737 34 biounit biounit NNP cord-015365-iqdi99pd 1737 35 transplantation transplantation NN cord-015365-iqdi99pd 1737 36 . . . cord-015365-iqdi99pd 1738 1 Restoration restoration NN cord-015365-iqdi99pd 1738 2 of of IN cord-015365-iqdi99pd 1738 3 hepatic hepatic JJ cord-015365-iqdi99pd 1738 4 lobe lobe NN cord-015365-iqdi99pd 1738 5 structure structure NN cord-015365-iqdi99pd 1738 6 was be VBD cord-015365-iqdi99pd 1738 7 better well JJR cord-015365-iqdi99pd 1738 8 in in IN cord-015365-iqdi99pd 1738 9 studied study VBN cord-015365-iqdi99pd 1738 10 group group NN cord-015365-iqdi99pd 1738 11 . . . cord-015365-iqdi99pd 1739 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1739 2 . . . cord-015365-iqdi99pd 1740 1 Our -PRON- PRP$ cord-015365-iqdi99pd 1740 2 preliminary preliminary JJ cord-015365-iqdi99pd 1740 3 studies study NNS cord-015365-iqdi99pd 1740 4 demonstrate demonstrate VBP cord-015365-iqdi99pd 1740 5 that that IN cord-015365-iqdi99pd 1740 6 in in IN cord-015365-iqdi99pd 1740 7 biounit biounit VBN cord-015365-iqdi99pd 1740 8 after after IN cord-015365-iqdi99pd 1740 9 transplantation transplantation NN cord-015365-iqdi99pd 1740 10 into into IN cord-015365-iqdi99pd 1740 11 damage damage NN cord-015365-iqdi99pd 1740 12 liver liver NN cord-015365-iqdi99pd 1740 13 there there EX cord-015365-iqdi99pd 1740 14 is be VBZ cord-015365-iqdi99pd 1740 15 formation formation NN cord-015365-iqdi99pd 1740 16 of of IN cord-015365-iqdi99pd 1740 17 morphologic morphologic JJ cord-015365-iqdi99pd 1740 18 structures structure NNS cord-015365-iqdi99pd 1740 19 of of IN cord-015365-iqdi99pd 1740 20 liver liver NN cord-015365-iqdi99pd 1740 21 ( ( -LRB- cord-015365-iqdi99pd 1740 22 viable viable JJ cord-015365-iqdi99pd 1740 23 cell cell NN cord-015365-iqdi99pd 1740 24 , , , cord-015365-iqdi99pd 1740 25 vessels vessel NNS cord-015365-iqdi99pd 1740 26 , , , cord-015365-iqdi99pd 1740 27 bile bile NN cord-015365-iqdi99pd 1740 28 ducts duct NNS cord-015365-iqdi99pd 1740 29 ) ) -RRB- cord-015365-iqdi99pd 1740 30 ; ; : cord-015365-iqdi99pd 1740 31 other other JJ cord-015365-iqdi99pd 1740 32 words word NNS cord-015365-iqdi99pd 1740 33 the the DT cord-015365-iqdi99pd 1740 34 used use VBN cord-015365-iqdi99pd 1740 35 method method NN cord-015365-iqdi99pd 1740 36 allows allow VBZ cord-015365-iqdi99pd 1740 37 to to TO cord-015365-iqdi99pd 1740 38 carry carry VB cord-015365-iqdi99pd 1740 39 out out RP cord-015365-iqdi99pd 1740 40 organotypic organotypic JJ cord-015365-iqdi99pd 1740 41 liver liver NN cord-015365-iqdi99pd 1740 42 remodeling remodeling NN cord-015365-iqdi99pd 1740 43 into into IN cord-015365-iqdi99pd 1740 44 biounit biounit NNP cord-015365-iqdi99pd 1740 45 and and CC cord-015365-iqdi99pd 1740 46 to to TO cord-015365-iqdi99pd 1740 47 support support VB cord-015365-iqdi99pd 1740 48 the the DT cord-015365-iqdi99pd 1740 49 function function NN cord-015365-iqdi99pd 1740 50 of of IN cord-015365-iqdi99pd 1740 51 the the DT cord-015365-iqdi99pd 1740 52 damaged damage VBN cord-015365-iqdi99pd 1740 53 liver liver NN cord-015365-iqdi99pd 1740 54 . . . cord-015365-iqdi99pd 1741 1 Thereby thereby RB cord-015365-iqdi99pd 1741 2 the the DT cord-015365-iqdi99pd 1741 3 suggested suggest VBN cord-015365-iqdi99pd 1741 4 method method NN cord-015365-iqdi99pd 1741 5 is be VBZ cord-015365-iqdi99pd 1741 6 a a DT cord-015365-iqdi99pd 1741 7 perspective perspective NN cord-015365-iqdi99pd 1741 8 one one NN cord-015365-iqdi99pd 1741 9 and and CC cord-015365-iqdi99pd 1741 10 can can MD cord-015365-iqdi99pd 1741 11 be be VB cord-015365-iqdi99pd 1741 12 used use VBN cord-015365-iqdi99pd 1741 13 as as IN cord-015365-iqdi99pd 1741 14 technology technology NN cord-015365-iqdi99pd 1741 15 of of IN cord-015365-iqdi99pd 1741 16 building build VBG cord-015365-iqdi99pd 1741 17 intracorporeal intracorporeal NN cord-015365-iqdi99pd 1741 18 biounit biounit VBN cord-015365-iqdi99pd 1741 19 for for IN cord-015365-iqdi99pd 1741 20 the the DT cord-015365-iqdi99pd 1741 21 long long JJ cord-015365-iqdi99pd 1741 22 - - HYPH cord-015365-iqdi99pd 1741 23 term term NN cord-015365-iqdi99pd 1741 24 auxiliary auxiliary JJ cord-015365-iqdi99pd 1741 25 supporting supporting NN cord-015365-iqdi99pd 1741 26 of of IN cord-015365-iqdi99pd 1741 27 the the DT cord-015365-iqdi99pd 1741 28 damaged damage VBN cord-015365-iqdi99pd 1741 29 organs organ NNS cord-015365-iqdi99pd 1741 30 . . . cord-015365-iqdi99pd 1742 1 Liposomales Liposomales NNP cord-015365-iqdi99pd 1742 2 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 1742 3 B b NN cord-015365-iqdi99pd 1742 4 als als NN cord-015365-iqdi99pd 1743 1 Prophylaxe Prophylaxe NNP cord-015365-iqdi99pd 1743 2 invasiver invasiver NNP cord-015365-iqdi99pd 1744 1 Pilzinfektionen Pilzinfektionen NNP cord-015365-iqdi99pd 1744 2 nach nach NNP cord-015365-iqdi99pd 1744 3 hämatopoietischer hämatopoietischer NNP cord-015365-iqdi99pd 1744 4 Stammzelltransplantation Stammzelltransplantation NNP cord-015365-iqdi99pd 1744 5 bei bei NNP cord-015365-iqdi99pd 1744 6 pädiatrischen pädiatrischen NNP cord-015365-iqdi99pd 1744 7 und und RB cord-015365-iqdi99pd 1744 8 adoleszenten adoleszenten NNP cord-015365-iqdi99pd 1745 1 Patienten Patienten NNP cord-015365-iqdi99pd 1745 2 photericin photericin NNS cord-015365-iqdi99pd 1746 1 B B NNP cord-015365-iqdi99pd 1746 2 ( ( -LRB- cord-015365-iqdi99pd 1746 3 LAMB LAMB NNP cord-015365-iqdi99pd 1746 4 ) ) -RRB- cord-015365-iqdi99pd 1747 1 sind sind NNP cord-015365-iqdi99pd 1748 1 ein ein NNP cord-015365-iqdi99pd 1748 2 breites breites NNP cord-015365-iqdi99pd 1748 3 antifungales antifungales NNP cord-015365-iqdi99pd 1748 4 Spektrum Spektrum NNP cord-015365-iqdi99pd 1748 5 , , , cord-015365-iqdi99pd 1748 6 eine eine NNP cord-015365-iqdi99pd 1748 7 lange lange NNP cord-015365-iqdi99pd 1748 8 Eliminations Eliminations NNPS cord-015365-iqdi99pd 1748 9 - - HYPH cord-015365-iqdi99pd 1748 10 Halbwertszeit Halbwertszeit NNP cord-015365-iqdi99pd 1748 11 , , , cord-015365-iqdi99pd 1748 12 und und IN cord-015365-iqdi99pd 1748 13 i -PRON- PRP cord-015365-iqdi99pd 1748 14 m be VBP cord-015365-iqdi99pd 1748 15 Vergleich Vergleich NNP cord-015365-iqdi99pd 1748 16 zu zu NNP cord-015365-iqdi99pd 1748 17 den den NNP cord-015365-iqdi99pd 1748 18 neuen neuen NNP cord-015365-iqdi99pd 1748 19 Azolen Azolen NNP cord-015365-iqdi99pd 1748 20 weniger weniger NNP cord-015365-iqdi99pd 1748 21 Medikamenten Medikamenten NNP cord-015365-iqdi99pd 1748 22 - - HYPH cord-015365-iqdi99pd 1748 23 Interaktionen Interaktionen NNP cord-015365-iqdi99pd 1748 24 . . . cord-015365-iqdi99pd 1749 1 Methodik Methodik NNP cord-015365-iqdi99pd 1749 2 . . . cord-015365-iqdi99pd 1750 1 I -PRON- PRP cord-015365-iqdi99pd 1750 2 m be VBP cord-015365-iqdi99pd 1750 3 Zeitraum Zeitraum NNP cord-015365-iqdi99pd 1750 4 2009 2009 CD cord-015365-iqdi99pd 1750 5 - - SYM cord-015365-iqdi99pd 1750 6 2010 2010 CD cord-015365-iqdi99pd 1750 7 wurden wurden NNS cord-015365-iqdi99pd 1750 8 bei bei NNP cord-015365-iqdi99pd 1750 9 20 20 CD cord-015365-iqdi99pd 1751 1 konsekutiven konsekutiven NNP cord-015365-iqdi99pd 1751 2 Patienten Patienten NNP cord-015365-iqdi99pd 1752 1 ( ( -LRB- cord-015365-iqdi99pd 1752 2 medianes medianes NNP cord-015365-iqdi99pd 1752 3 Alter Alter NNP cord-015365-iqdi99pd 1752 4 : : : cord-015365-iqdi99pd 1752 5 11,4 11,4 CD cord-015365-iqdi99pd 1752 6 Jahre Jahre NNP cord-015365-iqdi99pd 1752 7 ; ; : cord-015365-iqdi99pd 1753 1 m m NNP cord-015365-iqdi99pd 1753 2 : : : cord-015365-iqdi99pd 1753 3 w w NNP cord-015365-iqdi99pd 1753 4 ¼ ¼ NNP cord-015365-iqdi99pd 1753 5 8:12 8:12 CD cord-015365-iqdi99pd 1753 6 ) ) -RRB- cord-015365-iqdi99pd 1753 7 insgesamt insgesamt NNP cord-015365-iqdi99pd 1753 8 23 23 CD cord-015365-iqdi99pd 1753 9 HSZT HSZT NNP cord-015365-iqdi99pd 1753 10 durchgeführt durchgeführt NN cord-015365-iqdi99pd 1753 11 : : : cord-015365-iqdi99pd 1753 12 12 12 CD cord-015365-iqdi99pd 1753 13 autologe autologe NNP cord-015365-iqdi99pd 1753 14 ( ( -LRB- cord-015365-iqdi99pd 1753 15 davon davon NNP cord-015365-iqdi99pd 1753 16 3 3 CD cord-015365-iqdi99pd 1754 1 Tandem Tandem NNP cord-015365-iqdi99pd 1754 2 - - HYPH cord-015365-iqdi99pd 1754 3 Transplantationen Transplantationen NNP cord-015365-iqdi99pd 1754 4 ) ) -RRB- cord-015365-iqdi99pd 1754 5 und und VBD cord-015365-iqdi99pd 1754 6 11 11 CD cord-015365-iqdi99pd 1754 7 allogene allogene NN cord-015365-iqdi99pd 1754 8 SZT SZT NNP cord-015365-iqdi99pd 1754 9 , , , cord-015365-iqdi99pd 1754 10 wegen wegen NNP cord-015365-iqdi99pd 1754 11 soliden soliden NNP cord-015365-iqdi99pd 1754 12 Tumoren Tumoren NNP cord-015365-iqdi99pd 1754 13 ( ( -LRB- cord-015365-iqdi99pd 1754 14 n n NNP cord-015365-iqdi99pd 1754 15 ¼ ¼ NNP cord-015365-iqdi99pd 1754 16 7 7 CD cord-015365-iqdi99pd 1754 17 ) ) -RRB- cord-015365-iqdi99pd 1754 18 , , , cord-015365-iqdi99pd 1754 19 rezidivierter rezidivierter NNP cord-015365-iqdi99pd 1754 20 schwerer schwerer NNP cord-015365-iqdi99pd 1754 21 aplastischer aplastischer NNP cord-015365-iqdi99pd 1754 22 Anämie Anämie NNP cord-015365-iqdi99pd 1754 23 ( ( -LRB- cord-015365-iqdi99pd 1754 24 n n NNP cord-015365-iqdi99pd 1754 25 ¼ ¼ NNP cord-015365-iqdi99pd 1754 26 5 5 CD cord-015365-iqdi99pd 1754 27 ) ) -RRB- cord-015365-iqdi99pd 1754 28 , , . cord-015365-iqdi99pd 1755 1 malignen malignen NNP cord-015365-iqdi99pd 1755 2 hämatologischen hämatologischen NNP cord-015365-iqdi99pd 1755 3 Erkrankungen Erkrankungen NNP cord-015365-iqdi99pd 1755 4 ( ( -LRB- cord-015365-iqdi99pd 1755 5 n n NN cord-015365-iqdi99pd 1755 6 ¼ ¼ NNP cord-015365-iqdi99pd 1755 7 5 5 CD cord-015365-iqdi99pd 1755 8 ) ) -RRB- cord-015365-iqdi99pd 1755 9 , , . cord-015365-iqdi99pd 1756 1 Mb Mb NNP cord-015365-iqdi99pd 1756 2 . . . cord-015365-iqdi99pd 1757 1 Hurler Hurler NNP cord-015365-iqdi99pd 1757 2 ( ( -LRB- cord-015365-iqdi99pd 1757 3 n n NN cord-015365-iqdi99pd 1757 4 ¼ ¼ NNP cord-015365-iqdi99pd 1757 5 2 2 CD cord-015365-iqdi99pd 1757 6 ) ) -RRB- cord-015365-iqdi99pd 1757 7 bzw bzw NNP cord-015365-iqdi99pd 1757 8 . . . cord-015365-iqdi99pd 1758 1 Mb Mb NNP cord-015365-iqdi99pd 1758 2 Crohn Crohn NNP cord-015365-iqdi99pd 1758 3 ( ( -LRB- cord-015365-iqdi99pd 1758 4 n n NNP cord-015365-iqdi99pd 1758 5 ¼ ¼ NNP cord-015365-iqdi99pd 1758 6 1 1 CD cord-015365-iqdi99pd 1758 7 ) ) -RRB- cord-015365-iqdi99pd 1758 8 . . . cord-015365-iqdi99pd 1759 1 Autolog Autolog NNP cord-015365-iqdi99pd 1759 2 transplantierte transplantierte NNP cord-015365-iqdi99pd 1760 1 Patienten Patienten NNP cord-015365-iqdi99pd 1760 2 erhielten erhielten NNP cord-015365-iqdi99pd 1761 1 i -PRON- PRP cord-015365-iqdi99pd 1761 2 m be VBP cord-015365-iqdi99pd 1761 3 Median Median NNP cord-015365-iqdi99pd 1761 4 7,46Â10 7,46â10 CD cord-015365-iqdi99pd 1761 5 6 6 CD cord-015365-iqdi99pd 1762 1 /kg /kg . cord-015365-iqdi99pd 1763 1 CD34þ CD34þ NNP cord-015365-iqdi99pd 1763 2 Zellen Zellen NNP cord-015365-iqdi99pd 1763 3 / / , cord-015365-iqdi99pd 1763 4 kg kg NNP cord-015365-iqdi99pd 1764 1 und und NNP cord-015365-iqdi99pd 1764 2 erreichten erreichten NNP cord-015365-iqdi99pd 1764 3 am be VBP cord-015365-iqdi99pd 1765 1 Median median JJ cord-015365-iqdi99pd 1765 2 Tag tag NN cord-015365-iqdi99pd 1765 3 þ þ NNP cord-015365-iqdi99pd 1766 1 9,5 9,5 NNP cord-015365-iqdi99pd 1766 2 das das NNP cord-015365-iqdi99pd 1766 3 leukozytäre leukozytäre NNP cord-015365-iqdi99pd 1766 4 Engraftment Engraftment NNP cord-015365-iqdi99pd 1766 5 . . . cord-015365-iqdi99pd 1767 1 Allogene Allogene NNP cord-015365-iqdi99pd 1767 2 Stammzellquellen Stammzellquellen NNP cord-015365-iqdi99pd 1767 3 waren waren NNP cord-015365-iqdi99pd 1768 1 periphere periphere NNP cord-015365-iqdi99pd 1768 2 Stammzellen Stammzellen NNP cord-015365-iqdi99pd 1768 3 ( ( -LRB- cord-015365-iqdi99pd 1768 4 CD34þ CD34þ VBN cord-015365-iqdi99pd 1768 5 selektioniert selektioniert VB cord-015365-iqdi99pd 1769 1 und und NNP cord-015365-iqdi99pd 1769 2 / / SYM cord-015365-iqdi99pd 1769 3 oder oder NNP cord-015365-iqdi99pd 1769 4 CD3/19 CD3/19 NNP cord-015365-iqdi99pd 1769 5 depletiert depletiert NNP cord-015365-iqdi99pd 1769 6 ) ) -RRB- cord-015365-iqdi99pd 1769 7 in in IN cord-015365-iqdi99pd 1769 8 9 9 CD cord-015365-iqdi99pd 1769 9 und und IN cord-015365-iqdi99pd 1769 10 Knochenmark Knochenmark NNP cord-015365-iqdi99pd 1769 11 in in IN cord-015365-iqdi99pd 1769 12 2 2 CD cord-015365-iqdi99pd 1769 13 Fällen Fällen NNP cord-015365-iqdi99pd 1770 1 ; ; : cord-015365-iqdi99pd 1770 2 Spender Spender NNP cord-015365-iqdi99pd 1770 3 waren waren NNP cord-015365-iqdi99pd 1770 4 HLA HLA NNP cord-015365-iqdi99pd 1770 5 - - HYPH cord-015365-iqdi99pd 1770 6 idente idente NNP cord-015365-iqdi99pd 1771 1 Fremd-(n Fremd-(n NNP cord-015365-iqdi99pd 1771 2 ¼ ¼ NNP cord-015365-iqdi99pd 1771 3 9 9 CD cord-015365-iqdi99pd 1771 4 ) ) -RRB- cord-015365-iqdi99pd 1771 5 bzw bzw NNP cord-015365-iqdi99pd 1771 6 . . . cord-015365-iqdi99pd 1772 1 Geschwisterspender Geschwisterspender NNP cord-015365-iqdi99pd 1772 2 ( ( -LRB- cord-015365-iqdi99pd 1772 3 n n NN cord-015365-iqdi99pd 1772 4 ¼ ¼ NNP cord-015365-iqdi99pd 1772 5 1 1 CD cord-015365-iqdi99pd 1772 6 ) ) -RRB- cord-015365-iqdi99pd 1772 7 und und RB cord-015365-iqdi99pd 1773 1 ein ein NNP cord-015365-iqdi99pd 1773 2 haploidenter haploidenter NNP cord-015365-iqdi99pd 1773 3 Elternteil Elternteil NNP cord-015365-iqdi99pd 1773 4 . . . cord-015365-iqdi99pd 1774 1 Die die VB cord-015365-iqdi99pd 1774 2 mediane mediane NNP cord-015365-iqdi99pd 1774 3 Stammzellzahl Stammzellzahl NNP cord-015365-iqdi99pd 1774 4 lag lag VBP cord-015365-iqdi99pd 1774 5 bei bei NNP cord-015365-iqdi99pd 1774 6 15,37Â10 15,37â10 CD cord-015365-iqdi99pd 1774 7 6 6 CD cord-015365-iqdi99pd 1774 8 CD34þZellen CD34þZellen NNP cord-015365-iqdi99pd 1774 9 / / SYM cord-015365-iqdi99pd 1774 10 kg kg NN cord-015365-iqdi99pd 1774 11 ; ; : cord-015365-iqdi99pd 1775 1 das das NNP cord-015365-iqdi99pd 1775 2 leukozytäre leukozytäre NNP cord-015365-iqdi99pd 1775 3 Engraftment Engraftment NNP cord-015365-iqdi99pd 1775 4 erfolgte erfolgte NN cord-015365-iqdi99pd 1776 1 i i PRP cord-015365-iqdi99pd 1777 1 m m NNP cord-015365-iqdi99pd 1777 2 Median Median NNP cord-015365-iqdi99pd 1777 3 am be VBP cord-015365-iqdi99pd 1777 4 Tag tag NN cord-015365-iqdi99pd 1777 5 þ þ NNP cord-015365-iqdi99pd 1777 6 11 11 CD cord-015365-iqdi99pd 1777 7 . . . cord-015365-iqdi99pd 1778 1 Bei Bei NNP cord-015365-iqdi99pd 1778 2 5 5 CD cord-015365-iqdi99pd 1779 1 Patienten Patienten NNP cord-015365-iqdi99pd 1779 2 trat trat NNP cord-015365-iqdi99pd 1779 3 eine eine NNP cord-015365-iqdi99pd 1779 4 Graft graft NN cord-015365-iqdi99pd 1779 5 - - HYPH cord-015365-iqdi99pd 1779 6 versus versus IN cord-015365-iqdi99pd 1779 7 - - HYPH cord-015365-iqdi99pd 1779 8 host host NN cord-015365-iqdi99pd 1779 9 - - : cord-015365-iqdi99pd 1779 10 Erkrankung Erkrankung NNP cord-015365-iqdi99pd 1779 11 ( ( -LRB- cord-015365-iqdi99pd 1779 12 GVH GVH NNP cord-015365-iqdi99pd 1779 13 ) ) -RRB- cord-015365-iqdi99pd 1779 14 auf auf NNP cord-015365-iqdi99pd 1779 15 , , , cord-015365-iqdi99pd 1779 16 davon davon NNP cord-015365-iqdi99pd 1779 17 einmal einmal NNP cord-015365-iqdi99pd 1779 18 eine eine NNP cord-015365-iqdi99pd 1779 19 GVH GVH NNP cord-015365-iqdi99pd 1779 20 IV IV NNP cord-015365-iqdi99pd 1779 21 . . . cord-015365-iqdi99pd 1780 1 Die die VB cord-015365-iqdi99pd 1780 2 LAMB LAMB NNP cord-015365-iqdi99pd 1780 3 - - HYPH cord-015365-iqdi99pd 1780 4 Prophylaxe Prophylaxe VBN cord-015365-iqdi99pd 1780 5 wurde wurde NN cord-015365-iqdi99pd 1780 6 in in IN cord-015365-iqdi99pd 1780 7 einer einer NNP cord-015365-iqdi99pd 1780 8 Dosis Dosis NNP cord-015365-iqdi99pd 1780 9 von von NNP cord-015365-iqdi99pd 1780 10 5 5 CD cord-015365-iqdi99pd 1780 11 mg mg NNP cord-015365-iqdi99pd 1780 12 / / SYM cord-015365-iqdi99pd 1780 13 kg kg NNP cord-015365-iqdi99pd 1780 14 in in IN cord-015365-iqdi99pd 1780 15 3-tägigen 3-tägigen CD cord-015365-iqdi99pd 1780 16 ( ( -LRB- cord-015365-iqdi99pd 1780 17 n n NN cord-015365-iqdi99pd 1780 18 ¼ ¼ NNP cord-015365-iqdi99pd 1780 19 15 15 CD cord-015365-iqdi99pd 1780 20 ) ) -RRB- cord-015365-iqdi99pd 1781 1 oder oder NNP cord-015365-iqdi99pd 1782 1 2-tägigen 2-tägigen NNP cord-015365-iqdi99pd 1782 2 ( ( -LRB- cord-015365-iqdi99pd 1782 3 n n CC cord-015365-iqdi99pd 1782 4 ¼ ¼ NNP cord-015365-iqdi99pd 1782 5 8) 8) NNP cord-015365-iqdi99pd 1782 6 Intervallen Intervallen NNP cord-015365-iqdi99pd 1782 7 gestartet gestartet NNP cord-015365-iqdi99pd 1782 8 , , , cord-015365-iqdi99pd 1782 9 bei bei NNP cord-015365-iqdi99pd 1782 10 2 2 CD cord-015365-iqdi99pd 1782 11 Patienten Patienten NNP cord-015365-iqdi99pd 1782 12 mit mit NNP cord-015365-iqdi99pd 1782 13 refraktärer refraktärer NN cord-015365-iqdi99pd 1782 14 AML AML NNP cord-015365-iqdi99pd 1782 15 am be VBP cord-015365-iqdi99pd 1782 16 Tag Tag NNP cord-015365-iqdi99pd 1782 17 À46 à46 JJ cord-015365-iqdi99pd 1782 18 bzw bzw NN cord-015365-iqdi99pd 1782 19 . . . cord-015365-iqdi99pd 1783 1 À42 À42 NNP cord-015365-iqdi99pd 1783 2 , , , cord-015365-iqdi99pd 1783 3 bei bei NNP cord-015365-iqdi99pd 1783 4 allen allen NNP cord-015365-iqdi99pd 1783 5 anderen anderen NNP cord-015365-iqdi99pd 1783 6 Patienten Patienten NNP cord-015365-iqdi99pd 1784 1 i i PRP cord-015365-iqdi99pd 1785 1 m m NNP cord-015365-iqdi99pd 1785 2 Median Median NNP cord-015365-iqdi99pd 1785 3 am am NN cord-015365-iqdi99pd 1785 4 Tag Tag NNP cord-015365-iqdi99pd 1785 5 À3 à3 CD cord-015365-iqdi99pd 1785 6 . . . cord-015365-iqdi99pd 1786 1 Die die VB cord-015365-iqdi99pd 1787 1 Patienten Patienten NNP cord-015365-iqdi99pd 1787 2 erhielten erhielten NNP cord-015365-iqdi99pd 1788 1 i -PRON- PRP cord-015365-iqdi99pd 1788 2 m be VBP cord-015365-iqdi99pd 1788 3 Median Median NNP cord-015365-iqdi99pd 1788 4 11 11 CD cord-015365-iqdi99pd 1788 5 , , , cord-015365-iqdi99pd 1788 6 prophylaktische prophylaktische NN cord-015365-iqdi99pd 1788 7 Dosen Dosen NNP cord-015365-iqdi99pd 1788 8 bis bis NNP cord-015365-iqdi99pd 1788 9 zu zu XX cord-015365-iqdi99pd 1789 1 Median median JJ cord-015365-iqdi99pd 1789 2 Tag tag NN cord-015365-iqdi99pd 1789 3 þ20,5 þ20,5 NNP cord-015365-iqdi99pd 1789 4 ( ( -LRB- cord-015365-iqdi99pd 1789 5 þ11 þ11 DT cord-015365-iqdi99pd 1789 6 bis bis NN cord-015365-iqdi99pd 1789 7 þ43 þ43 NN cord-015365-iqdi99pd 1789 8 ) ) -RRB- cord-015365-iqdi99pd 1789 9 . . . cord-015365-iqdi99pd 1790 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 1790 2 . . . cord-015365-iqdi99pd 1791 1 Bei Bei NNP cord-015365-iqdi99pd 1791 2 8 8 CD cord-015365-iqdi99pd 1791 3 Patienten Patienten NNP cord-015365-iqdi99pd 1791 4 wurden wurden VBD cord-015365-iqdi99pd 1791 5 wegen wegen NNP cord-015365-iqdi99pd 1791 6 Fieber Fieber NNP cord-015365-iqdi99pd 1792 1 oder oder NNP cord-015365-iqdi99pd 1792 2 CRP CRP NNP cord-015365-iqdi99pd 1792 3 - - HYPH cord-015365-iqdi99pd 1792 4 Anstieg Anstieg NNP cord-015365-iqdi99pd 1792 5 die die VBP cord-015365-iqdi99pd 1792 6 Infusionsintervalle Infusionsintervalle NNP cord-015365-iqdi99pd 1792 7 verkürzt verkürzt NN cord-015365-iqdi99pd 1792 8 . . . cord-015365-iqdi99pd 1793 1 Eine Eine NNP cord-015365-iqdi99pd 1793 2 intermittierende intermittierende NNP cord-015365-iqdi99pd 1793 3 Candida Candida NNP cord-015365-iqdi99pd 1793 4 - - HYPH cord-015365-iqdi99pd 1793 5 Kolonisation Kolonisation NNP cord-015365-iqdi99pd 1793 6 wurde wurde NN cord-015365-iqdi99pd 1793 7 durch durch NNP cord-015365-iqdi99pd 1793 8 wöchentliche wöchentliche NNP cord-015365-iqdi99pd 1793 9 Ü Ü NNP cord-015365-iqdi99pd 1793 10 berwachungskulturen berwachungskulturen NNP cord-015365-iqdi99pd 1793 11 bei bei NNP cord-015365-iqdi99pd 1793 12 9 9 CD cord-015365-iqdi99pd 1794 1 Patienten Patienten NNP cord-015365-iqdi99pd 1794 2 detektiert detektiert NN cord-015365-iqdi99pd 1794 3 . . . cord-015365-iqdi99pd 1795 1 Wöchentliche Wöchentliche NNP cord-015365-iqdi99pd 1795 2 Galaktomannan Galaktomannan NNP cord-015365-iqdi99pd 1795 3 - - HYPH cord-015365-iqdi99pd 1795 4 Test Test NNP cord-015365-iqdi99pd 1795 5 blieben blieben NN cord-015365-iqdi99pd 1795 6 bei bei NNP cord-015365-iqdi99pd 1795 7 17 17 CD cord-015365-iqdi99pd 1795 8 Patienten Patienten NNP cord-015365-iqdi99pd 1795 9 durchgehend durchgehend NN cord-015365-iqdi99pd 1795 10 negativ negativ NNP cord-015365-iqdi99pd 1795 11 , , , cord-015365-iqdi99pd 1795 12 2 2 CD cord-015365-iqdi99pd 1795 13 Patienten Patienten NNP cord-015365-iqdi99pd 1795 14 hatten hatten NNP cord-015365-iqdi99pd 1796 1 je je NNP cord-015365-iqdi99pd 1796 2 ein ein NNP cord-015365-iqdi99pd 1796 3 einzelnes einzelne VBZ cord-015365-iqdi99pd 1796 4 positives positives NNPS cord-015365-iqdi99pd 1796 5 Testergebnis Testergebnis NNP cord-015365-iqdi99pd 1796 6 ; ; : cord-015365-iqdi99pd 1796 7 keiner keiner NNP cord-015365-iqdi99pd 1796 8 dieser dieser NNP cord-015365-iqdi99pd 1796 9 19 19 CD cord-015365-iqdi99pd 1796 10 Patienten Patienten NNP cord-015365-iqdi99pd 1796 11 entwickelte entwickelte NNP cord-015365-iqdi99pd 1796 12 während während JJ cord-015365-iqdi99pd 1796 13 einer einer NNP cord-015365-iqdi99pd 1796 14 medianen medianen NNP cord-015365-iqdi99pd 1796 15 Nachbeobachtungszeit Nachbeobachtungszeit NNP cord-015365-iqdi99pd 1796 16 von von NNP cord-015365-iqdi99pd 1796 17 10 10 CD cord-015365-iqdi99pd 1797 1 Monaten Monaten NNP cord-015365-iqdi99pd 1797 2 eine eine NNP cord-015365-iqdi99pd 1797 3 invasive invasive JJ cord-015365-iqdi99pd 1797 4 Pilzinfektion Pilzinfektion NNP cord-015365-iqdi99pd 1797 5 . . . cord-015365-iqdi99pd 1798 1 Eine Eine NNP cord-015365-iqdi99pd 1798 2 Patientin Patientin NNP cord-015365-iqdi99pd 1798 3 mit mit NNP cord-015365-iqdi99pd 1798 4 GVH GVH NNP cord-015365-iqdi99pd 1798 5 IV IV NNP cord-015365-iqdi99pd 1798 6 unter unter NNP cord-015365-iqdi99pd 1798 7 multimodaler multimodaler NNP cord-015365-iqdi99pd 1798 8 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 1798 9 und und IN cord-015365-iqdi99pd 1798 10 wiederholt wiederholt NN cord-015365-iqdi99pd 1798 11 positiven positiven NNP cord-015365-iqdi99pd 1798 12 Galaktomannan Galaktomannan NNP cord-015365-iqdi99pd 1798 13 - - HYPH cord-015365-iqdi99pd 1798 14 Tests Tests NNP cord-015365-iqdi99pd 1798 15 entwickelte entwickelte NNP cord-015365-iqdi99pd 1798 16 trotz trotz NNP cord-015365-iqdi99pd 1798 17 kontinuierlicher kontinuierlicher NNP cord-015365-iqdi99pd 1798 18 präemptiver präemptiver NNP cord-015365-iqdi99pd 1798 19 Therapie Therapie NNP cord-015365-iqdi99pd 1798 20 mit mit NNP cord-015365-iqdi99pd 1798 21 LAMB LAMB NNP cord-015365-iqdi99pd 1798 22 alternierend alternierend NN cord-015365-iqdi99pd 1798 23 mit mit NNP cord-015365-iqdi99pd 1798 24 Caspofungin Caspofungin NNP cord-015365-iqdi99pd 1799 1 präfinal präfinal NNP cord-015365-iqdi99pd 1799 2 eine eine NNP cord-015365-iqdi99pd 1799 3 Aspergillus Aspergillus NNP cord-015365-iqdi99pd 1799 4 - - HYPH cord-015365-iqdi99pd 1799 5 Pneumonie Pneumonie NNP cord-015365-iqdi99pd 1799 6 und und IN cord-015365-iqdi99pd 1799 7 verstarb verstarb NN cord-015365-iqdi99pd 1799 8 am be VBP cord-015365-iqdi99pd 1799 9 Tag tag NN cord-015365-iqdi99pd 1799 10 þ140 þ140 NNP cord-015365-iqdi99pd 1799 11 . . . cord-015365-iqdi99pd 1800 1 Bei Bei NNP cord-015365-iqdi99pd 1800 2 keinem keinem NN cord-015365-iqdi99pd 1800 3 Patienten Patienten NNP cord-015365-iqdi99pd 1800 4 mußte mußte NN cord-015365-iqdi99pd 1800 5 LAMB LAMB NNP cord-015365-iqdi99pd 1800 6 wegen wegen NNP cord-015365-iqdi99pd 1801 1 infusionsassoziierter infusionsassoziierter NNP cord-015365-iqdi99pd 1801 2 Nebenwirkungen Nebenwirkungen NNP cord-015365-iqdi99pd 1801 3 abgesetzt abgesetzt VBD cord-015365-iqdi99pd 1801 4 werden werden NNP cord-015365-iqdi99pd 1801 5 ; ; : cord-015365-iqdi99pd 1801 6 die die VB cord-015365-iqdi99pd 1801 7 Hauptnebenwirkung Hauptnebenwirkung NNP cord-015365-iqdi99pd 1801 8 war war NN cord-015365-iqdi99pd 1801 9 eine eine NNP cord-015365-iqdi99pd 1801 10 Hypokaliämie Hypokaliämie NNP cord-015365-iqdi99pd 1801 11 , , , cord-015365-iqdi99pd 1801 12 die die VBP cord-015365-iqdi99pd 1801 13 in in IN cord-015365-iqdi99pd 1801 14 20/23 20/23 CD cord-015365-iqdi99pd 1801 15 Anwendungen Anwendungen NNP cord-015365-iqdi99pd 1801 16 substitutionsbedürftig substitutionsbedürftig NNP cord-015365-iqdi99pd 1801 17 war war NN cord-015365-iqdi99pd 1801 18 . . . cord-015365-iqdi99pd 1802 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 1802 2 . . . cord-015365-iqdi99pd 1803 1 Die die VB cord-015365-iqdi99pd 1803 2 intermittierende intermittierende NNP cord-015365-iqdi99pd 1803 3 antifungale antifungale . cord-015365-iqdi99pd 1804 1 Prophylaxe Prophylaxe NNP cord-015365-iqdi99pd 1804 2 mit mit NN cord-015365-iqdi99pd 1804 3 LAMB LAMB NNP cord-015365-iqdi99pd 1804 4 nach nach NNP cord-015365-iqdi99pd 1804 5 autologer autologer NNP cord-015365-iqdi99pd 1804 6 bzw bzw NNP cord-015365-iqdi99pd 1804 7 . . . cord-015365-iqdi99pd 1805 1 allogener allogener JJ cord-015365-iqdi99pd 1805 2 SZT SZT NNP cord-015365-iqdi99pd 1805 3 war war NN cord-015365-iqdi99pd 1805 4 bei bei NN cord-015365-iqdi99pd 1805 5 19/20 19/20 CD cord-015365-iqdi99pd 1805 6 Patienten Patienten NNP cord-015365-iqdi99pd 1805 7 erfolgreich erfolgreich RB cord-015365-iqdi99pd 1805 8 . . . cord-015365-iqdi99pd 1806 1 Die die VB cord-015365-iqdi99pd 1806 2 Nebenwirkungen Nebenwirkungen NNP cord-015365-iqdi99pd 1806 3 beschränkten beschränkten VBD cord-015365-iqdi99pd 1806 4 sich sich NNP cord-015365-iqdi99pd 1806 5 auf auf NNP cord-015365-iqdi99pd 1806 6 eine eine NNP cord-015365-iqdi99pd 1806 7 substitutionsbedürftige substitutionsbedürftige NNP cord-015365-iqdi99pd 1806 8 Hypokaliämie Hypokaliämie NNP cord-015365-iqdi99pd 1806 9 . . . cord-015365-iqdi99pd 1807 1 Background background NN cord-015365-iqdi99pd 1807 2 . . . cord-015365-iqdi99pd 1808 1 Late late JJ cord-015365-iqdi99pd 1808 2 complications complication NNS cord-015365-iqdi99pd 1808 3 including include VBG cord-015365-iqdi99pd 1808 4 diabetic diabetic JJ cord-015365-iqdi99pd 1808 5 vasculopathy vasculopathy NNP cord-015365-iqdi99pd 1808 6 , , , cord-015365-iqdi99pd 1808 7 retinopathy retinopathy NN cord-015365-iqdi99pd 1808 8 and and CC cord-015365-iqdi99pd 1808 9 neuropathy neuropathy NN cord-015365-iqdi99pd 1808 10 are be VBP cord-015365-iqdi99pd 1808 11 still still RB cord-015365-iqdi99pd 1808 12 serious serious JJ cord-015365-iqdi99pd 1808 13 problems problem NNS cord-015365-iqdi99pd 1808 14 in in IN cord-015365-iqdi99pd 1808 15 the the DT cord-015365-iqdi99pd 1808 16 treatment treatment NN cord-015365-iqdi99pd 1808 17 of of IN cord-015365-iqdi99pd 1808 18 diabetes diabetes NN cord-015365-iqdi99pd 1808 19 mellitus mellitus NN cord-015365-iqdi99pd 1808 20 . . . cord-015365-iqdi99pd 1809 1 Whole whole JJ cord-015365-iqdi99pd 1809 2 pancreas pancreas NN cord-015365-iqdi99pd 1809 3 transplantation transplantation NN cord-015365-iqdi99pd 1809 4 or or CC cord-015365-iqdi99pd 1809 5 human human JJ cord-015365-iqdi99pd 1809 6 islet islet NN cord-015365-iqdi99pd 1809 7 cell cell NN cord-015365-iqdi99pd 1809 8 transplantation transplantation NN cord-015365-iqdi99pd 1809 9 are be VBP cord-015365-iqdi99pd 1809 10 alternatives alternative NNS cord-015365-iqdi99pd 1809 11 but but CC cord-015365-iqdi99pd 1809 12 limited limit VBN cord-015365-iqdi99pd 1809 13 due due IN cord-015365-iqdi99pd 1809 14 to to IN cord-015365-iqdi99pd 1809 15 the the DT cord-015365-iqdi99pd 1809 16 organ organ NN cord-015365-iqdi99pd 1809 17 shortage shortage NN cord-015365-iqdi99pd 1809 18 and and CC cord-015365-iqdi99pd 1809 19 lifelong lifelong JJ cord-015365-iqdi99pd 1809 20 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1809 21 . . . cord-015365-iqdi99pd 1810 1 The the DT cord-015365-iqdi99pd 1810 2 use use NN cord-015365-iqdi99pd 1810 3 of of IN cord-015365-iqdi99pd 1810 4 immune immune JJ cord-015365-iqdi99pd 1810 5 isolated isolate VBN cord-015365-iqdi99pd 1810 6 porcine porcine JJ cord-015365-iqdi99pd 1810 7 islet islet NN cord-015365-iqdi99pd 1810 8 cells cell NNS cord-015365-iqdi99pd 1810 9 ( ( -LRB- cord-015365-iqdi99pd 1810 10 PIC pic NN cord-015365-iqdi99pd 1810 11 ) ) -RRB- cord-015365-iqdi99pd 1810 12 could could MD cord-015365-iqdi99pd 1810 13 offer offer VB cord-015365-iqdi99pd 1810 14 a a DT cord-015365-iqdi99pd 1810 15 feasible feasible JJ cord-015365-iqdi99pd 1810 16 alternative alternative NN cord-015365-iqdi99pd 1810 17 . . . cord-015365-iqdi99pd 1811 1 In in IN cord-015365-iqdi99pd 1811 2 this this DT cord-015365-iqdi99pd 1811 3 study study NN cord-015365-iqdi99pd 1811 4 , , , cord-015365-iqdi99pd 1811 5 the the DT cord-015365-iqdi99pd 1811 6 safety safety NN cord-015365-iqdi99pd 1811 7 and and CC cord-015365-iqdi99pd 1811 8 applicability applicability NN cord-015365-iqdi99pd 1811 9 of of IN cord-015365-iqdi99pd 1811 10 three three CD cord-015365-iqdi99pd 1811 11 possible possible JJ cord-015365-iqdi99pd 1811 12 implantation implantation NN cord-015365-iqdi99pd 1811 13 sites site NNS cord-015365-iqdi99pd 1811 14 for for IN cord-015365-iqdi99pd 1811 15 Sodium sodium NN cord-015365-iqdi99pd 1811 16 Cellulose Cellulose NNP cord-015365-iqdi99pd 1811 17 Sulfate Sulfate NNP cord-015365-iqdi99pd 1811 18 ( ( -LRB- cord-015365-iqdi99pd 1811 19 SCS SCS NNP cord-015365-iqdi99pd 1811 20 ) ) -RRB- cord-015365-iqdi99pd 1811 21 microencapsulated microencapsulate VBN cord-015365-iqdi99pd 1811 22 PIC PIC NNP cord-015365-iqdi99pd 1811 23 were be VBD cord-015365-iqdi99pd 1811 24 evaluated evaluate VBN cord-015365-iqdi99pd 1811 25 in in IN cord-015365-iqdi99pd 1811 26 five five CD cord-015365-iqdi99pd 1811 27 healthy healthy JJ cord-015365-iqdi99pd 1811 28 beagle beagle NN cord-015365-iqdi99pd 1811 29 dogs dog NNS cord-015365-iqdi99pd 1811 30 . . . cord-015365-iqdi99pd 1812 1 Methods method NNS cord-015365-iqdi99pd 1812 2 . . . cord-015365-iqdi99pd 1813 1 Five five CD cord-015365-iqdi99pd 1813 2 healthy healthy JJ cord-015365-iqdi99pd 1813 3 , , , cord-015365-iqdi99pd 1813 4 male male JJ cord-015365-iqdi99pd 1813 5 castrated castrate VBN cord-015365-iqdi99pd 1813 6 Beagle Beagle NNP cord-015365-iqdi99pd 1813 7 dogs dog NNS cord-015365-iqdi99pd 1813 8 were be VBD cord-015365-iqdi99pd 1813 9 used use VBN cord-015365-iqdi99pd 1813 10 for for IN cord-015365-iqdi99pd 1813 11 this this DT cord-015365-iqdi99pd 1813 12 study study NN cord-015365-iqdi99pd 1813 13 . . . cord-015365-iqdi99pd 1814 1 SCS SCS NNP cord-015365-iqdi99pd 1814 2 microencapsulated microencapsulate VBN cord-015365-iqdi99pd 1814 3 PIC PIC NNP cord-015365-iqdi99pd 1814 4 were be VBD cord-015365-iqdi99pd 1814 5 implanted implant VBN cord-015365-iqdi99pd 1814 6 in in IN cord-015365-iqdi99pd 1814 7 the the DT cord-015365-iqdi99pd 1814 8 subcutaneous subcutaneous JJ cord-015365-iqdi99pd 1814 9 tissue tissue NN cord-015365-iqdi99pd 1814 10 , , , cord-015365-iqdi99pd 1814 11 the the DT cord-015365-iqdi99pd 1814 12 omentum omentum NN cord-015365-iqdi99pd 1814 13 and and CC cord-015365-iqdi99pd 1814 14 the the DT cord-015365-iqdi99pd 1814 15 gastric gastric JJ cord-015365-iqdi99pd 1814 16 submucosa submucosa NN cord-015365-iqdi99pd 1814 17 . . . cord-015365-iqdi99pd 1815 1 Surgery surgery NN cord-015365-iqdi99pd 1815 2 time time NN cord-015365-iqdi99pd 1815 3 and and CC cord-015365-iqdi99pd 1815 4 intraoperative intraoperative JJ cord-015365-iqdi99pd 1815 5 complications complication NNS cord-015365-iqdi99pd 1815 6 were be VBD cord-015365-iqdi99pd 1815 7 monitored monitor VBN cord-015365-iqdi99pd 1815 8 . . . cord-015365-iqdi99pd 1816 1 Implantation implantation NN cord-015365-iqdi99pd 1816 2 in in IN cord-015365-iqdi99pd 1816 3 the the DT cord-015365-iqdi99pd 1816 4 omentum omentum NN cord-015365-iqdi99pd 1816 5 and and CC cord-015365-iqdi99pd 1816 6 gastric gastric NNP cord-015365-iqdi99pd 1816 7 submucosa submucosa NNP cord-015365-iqdi99pd 1816 8 was be VBD cord-015365-iqdi99pd 1816 9 performed perform VBN cord-015365-iqdi99pd 1816 10 laparoscopic laparoscopic JJ cord-015365-iqdi99pd 1816 11 assisted assist VBN cord-015365-iqdi99pd 1816 12 . . . cord-015365-iqdi99pd 1817 1 All all DT cord-015365-iqdi99pd 1817 2 animals animal NNS cord-015365-iqdi99pd 1817 3 were be VBD cord-015365-iqdi99pd 1817 4 continuously continuously RB cord-015365-iqdi99pd 1817 5 monitored monitor VBN cord-015365-iqdi99pd 1817 6 including include VBG cord-015365-iqdi99pd 1817 7 clinical clinical JJ cord-015365-iqdi99pd 1817 8 examinations examination NNS cord-015365-iqdi99pd 1817 9 and and CC cord-015365-iqdi99pd 1817 10 complete complete VB cord-015365-iqdi99pd 1817 11 blood blood NN cord-015365-iqdi99pd 1817 12 counts count NNS cord-015365-iqdi99pd 1817 13 for for IN cord-015365-iqdi99pd 1817 14 possible possible JJ cord-015365-iqdi99pd 1817 15 occurring occur VBG cord-015365-iqdi99pd 1817 16 side side NN cord-015365-iqdi99pd 1817 17 effects effect NNS cord-015365-iqdi99pd 1817 18 . . . cord-015365-iqdi99pd 1818 1 On on IN cord-015365-iqdi99pd 1818 2 day day NN cord-015365-iqdi99pd 1818 3 À3 à3 CD cord-015365-iqdi99pd 1818 4 , , , cord-015365-iqdi99pd 1818 5 30 30 CD cord-015365-iqdi99pd 1818 6 and and CC cord-015365-iqdi99pd 1818 7 90 90 CD cord-015365-iqdi99pd 1818 8 a a DT cord-015365-iqdi99pd 1818 9 glucagon glucagon NN cord-015365-iqdi99pd 1818 10 stimulation stimulation NN cord-015365-iqdi99pd 1818 11 test test NN cord-015365-iqdi99pd 1818 12 was be VBD cord-015365-iqdi99pd 1818 13 performed perform VBN cord-015365-iqdi99pd 1818 14 to to TO cord-015365-iqdi99pd 1818 15 assess assess VB cord-015365-iqdi99pd 1818 16 -cell -cell JJ cord-015365-iqdi99pd 1818 17 function function NN cord-015365-iqdi99pd 1818 18 and and CC cord-015365-iqdi99pd 1818 19 glucose glucose NN cord-015365-iqdi99pd 1818 20 metabolism metabolism NN cord-015365-iqdi99pd 1818 21 . . . cord-015365-iqdi99pd 1819 1 On on IN cord-015365-iqdi99pd 1819 2 day day NN cord-015365-iqdi99pd 1819 3 À3 à3 CD cord-015365-iqdi99pd 1819 4 , , , cord-015365-iqdi99pd 1819 5 1 1 CD cord-015365-iqdi99pd 1819 6 , , , cord-015365-iqdi99pd 1819 7 3 3 CD cord-015365-iqdi99pd 1819 8 , , , cord-015365-iqdi99pd 1819 9 12 12 CD cord-015365-iqdi99pd 1819 10 , , , cord-015365-iqdi99pd 1819 11 30 30 CD cord-015365-iqdi99pd 1819 12 , , , cord-015365-iqdi99pd 1819 13 60 60 CD cord-015365-iqdi99pd 1819 14 and and CC cord-015365-iqdi99pd 1819 15 90 90 CD cord-015365-iqdi99pd 1819 16 fasting fast VBG cord-015365-iqdi99pd 1819 17 glucose glucose NN cord-015365-iqdi99pd 1819 18 and and CC cord-015365-iqdi99pd 1819 19 insulin insulin NN cord-015365-iqdi99pd 1819 20 were be VBD cord-015365-iqdi99pd 1819 21 measured measure VBN cord-015365-iqdi99pd 1819 22 . . . cord-015365-iqdi99pd 1820 1 Blood blood NN cord-015365-iqdi99pd 1820 2 samples sample NNS cord-015365-iqdi99pd 1820 3 were be VBD cord-015365-iqdi99pd 1820 4 taken take VBN cord-015365-iqdi99pd 1820 5 to to TO cord-015365-iqdi99pd 1820 6 check check VB cord-015365-iqdi99pd 1820 7 a a DT cord-015365-iqdi99pd 1820 8 possible possible JJ cord-015365-iqdi99pd 1820 9 porcine porcine JJ cord-015365-iqdi99pd 1820 10 endogenous endogenous JJ cord-015365-iqdi99pd 1820 11 retrovirus retrovirus NN cord-015365-iqdi99pd 1820 12 ( ( -LRB- cord-015365-iqdi99pd 1820 13 PERV perv NN cord-015365-iqdi99pd 1820 14 ) ) -RRB- cord-015365-iqdi99pd 1820 15 transmission transmission NN cord-015365-iqdi99pd 1820 16 . . . cord-015365-iqdi99pd 1821 1 Biopsies biopsy NNS cord-015365-iqdi99pd 1821 2 of of IN cord-015365-iqdi99pd 1821 3 all all DT cord-015365-iqdi99pd 1821 4 implantation implantation NN cord-015365-iqdi99pd 1821 5 sites site NNS cord-015365-iqdi99pd 1821 6 were be VBD cord-015365-iqdi99pd 1821 7 obtained obtain VBN cord-015365-iqdi99pd 1821 8 for for IN cord-015365-iqdi99pd 1821 9 histopathology histopathology NN cord-015365-iqdi99pd 1821 10 on on IN cord-015365-iqdi99pd 1821 11 day day NN cord-015365-iqdi99pd 1821 12 90 90 CD cord-015365-iqdi99pd 1821 13 . . . cord-015365-iqdi99pd 1822 1 Results result NNS cord-015365-iqdi99pd 1822 2 . . . cord-015365-iqdi99pd 1823 1 No no DT cord-015365-iqdi99pd 1823 2 technical technical JJ cord-015365-iqdi99pd 1823 3 complications complication NNS cord-015365-iqdi99pd 1823 4 occurred occur VBD cord-015365-iqdi99pd 1823 5 at at IN cord-015365-iqdi99pd 1823 6 the the DT cord-015365-iqdi99pd 1823 7 subcutis subcutis NN cord-015365-iqdi99pd 1823 8 and and CC cord-015365-iqdi99pd 1823 9 omentum omentum NN cord-015365-iqdi99pd 1823 10 site site NN cord-015365-iqdi99pd 1823 11 . . . cord-015365-iqdi99pd 1824 1 At at IN cord-015365-iqdi99pd 1824 2 the the DT cord-015365-iqdi99pd 1824 3 gastric gastric JJ cord-015365-iqdi99pd 1824 4 submucosa submucosa NNPS cord-015365-iqdi99pd 1824 5 only only RB cord-015365-iqdi99pd 1824 6 a a DT cord-015365-iqdi99pd 1824 7 limited limited JJ cord-015365-iqdi99pd 1824 8 amount amount NN cord-015365-iqdi99pd 1824 9 of of IN cord-015365-iqdi99pd 1824 10 cells cell NNS cord-015365-iqdi99pd 1824 11 could could MD cord-015365-iqdi99pd 1824 12 be be VB cord-015365-iqdi99pd 1824 13 implanted implant VBN cord-015365-iqdi99pd 1824 14 . . . cord-015365-iqdi99pd 1825 1 Delayed delay VBN cord-015365-iqdi99pd 1825 2 wound wound NN cord-015365-iqdi99pd 1825 3 healing healing NN cord-015365-iqdi99pd 1825 4 at at IN cord-015365-iqdi99pd 1825 5 the the DT cord-015365-iqdi99pd 1825 6 subcutaneous subcutaneous JJ cord-015365-iqdi99pd 1825 7 implantation implantation NN cord-015365-iqdi99pd 1825 8 site site NN cord-015365-iqdi99pd 1825 9 was be VBD cord-015365-iqdi99pd 1825 10 observed observe VBN cord-015365-iqdi99pd 1825 11 in in IN cord-015365-iqdi99pd 1825 12 three three CD cord-015365-iqdi99pd 1825 13 out out IN cord-015365-iqdi99pd 1825 14 of of IN cord-015365-iqdi99pd 1825 15 five five CD cord-015365-iqdi99pd 1825 16 dogs dog NNS cord-015365-iqdi99pd 1825 17 . . . cord-015365-iqdi99pd 1826 1 No no DT cord-015365-iqdi99pd 1826 2 further further JJ cord-015365-iqdi99pd 1826 3 side side NN cord-015365-iqdi99pd 1826 4 effects effect NNS cord-015365-iqdi99pd 1826 5 occured occur VBD cord-015365-iqdi99pd 1826 6 during during IN cord-015365-iqdi99pd 1826 7 the the DT cord-015365-iqdi99pd 1826 8 study study NN cord-015365-iqdi99pd 1826 9 period period NN cord-015365-iqdi99pd 1826 10 . . . cord-015365-iqdi99pd 1827 1 Transmission transmission NN cord-015365-iqdi99pd 1827 2 of of IN cord-015365-iqdi99pd 1827 3 PERV perv NN cord-015365-iqdi99pd 1827 4 was be VBD cord-015365-iqdi99pd 1827 5 not not RB cord-015365-iqdi99pd 1827 6 detected detect VBN cord-015365-iqdi99pd 1827 7 . . . cord-015365-iqdi99pd 1828 1 Glucagon glucagon NN cord-015365-iqdi99pd 1828 2 stimulation stimulation NN cord-015365-iqdi99pd 1828 3 tests test NNS cord-015365-iqdi99pd 1828 4 showed show VBD cord-015365-iqdi99pd 1828 5 a a DT cord-015365-iqdi99pd 1828 6 trend trend NN cord-015365-iqdi99pd 1828 7 towards towards IN cord-015365-iqdi99pd 1828 8 a a DT cord-015365-iqdi99pd 1828 9 faster fast JJR cord-015365-iqdi99pd 1828 10 response response NN cord-015365-iqdi99pd 1828 11 to to IN cord-015365-iqdi99pd 1828 12 a a DT cord-015365-iqdi99pd 1828 13 glucagon glucagon NN cord-015365-iqdi99pd 1828 14 stimulus stimulus NN cord-015365-iqdi99pd 1828 15 and and CC cord-015365-iqdi99pd 1828 16 an an DT cord-015365-iqdi99pd 1828 17 increased increase VBN cord-015365-iqdi99pd 1828 18 insulin insulin NN cord-015365-iqdi99pd 1828 19 peak peak NN cord-015365-iqdi99pd 1828 20 . . . cord-015365-iqdi99pd 1829 1 Histopathology Histopathology NNP cord-015365-iqdi99pd 1829 2 results result NNS cord-015365-iqdi99pd 1829 3 have have VBP cord-015365-iqdi99pd 1829 4 not not RB cord-015365-iqdi99pd 1829 5 been be VBN cord-015365-iqdi99pd 1829 6 completely completely RB cord-015365-iqdi99pd 1829 7 evaluated evaluate VBN cord-015365-iqdi99pd 1829 8 yet yet RB cord-015365-iqdi99pd 1829 9 . . . cord-015365-iqdi99pd 1830 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1830 2 . . . cord-015365-iqdi99pd 1831 1 First first JJ cord-015365-iqdi99pd 1831 2 results result NNS cord-015365-iqdi99pd 1831 3 show show VBP cord-015365-iqdi99pd 1831 4 that that IN cord-015365-iqdi99pd 1831 5 SCS SCS NNP cord-015365-iqdi99pd 1831 6 microencapsulated microencapsulate VBN cord-015365-iqdi99pd 1831 7 PIC PIC NNP cord-015365-iqdi99pd 1831 8 do do VBP cord-015365-iqdi99pd 1831 9 not not RB cord-015365-iqdi99pd 1831 10 cause cause VB cord-015365-iqdi99pd 1831 11 any any DT cord-015365-iqdi99pd 1831 12 harmful harmful JJ cord-015365-iqdi99pd 1831 13 side side NN cord-015365-iqdi99pd 1831 14 effects effect NNS cord-015365-iqdi99pd 1831 15 to to IN cord-015365-iqdi99pd 1831 16 the the DT cord-015365-iqdi99pd 1831 17 recipients recipient NNS cord-015365-iqdi99pd 1831 18 concerning concern VBG cord-015365-iqdi99pd 1831 19 application application NN cord-015365-iqdi99pd 1831 20 . . . cord-015365-iqdi99pd 1832 1 No no DT cord-015365-iqdi99pd 1832 2 transmission transmission NN cord-015365-iqdi99pd 1832 3 of of IN cord-015365-iqdi99pd 1832 4 PERV perv NN cord-015365-iqdi99pd 1832 5 was be VBD cord-015365-iqdi99pd 1832 6 detected detect VBN cord-015365-iqdi99pd 1832 7 . . . cord-015365-iqdi99pd 1833 1 The the DT cord-015365-iqdi99pd 1833 2 outcome outcome NN cord-015365-iqdi99pd 1833 3 of of IN cord-015365-iqdi99pd 1833 4 histopathology histopathology NN cord-015365-iqdi99pd 1833 5 in in IN cord-015365-iqdi99pd 1833 6 combination combination NN cord-015365-iqdi99pd 1833 7 with with IN cord-015365-iqdi99pd 1833 8 the the DT cord-015365-iqdi99pd 1833 9 clinical clinical JJ cord-015365-iqdi99pd 1833 10 results result NNS cord-015365-iqdi99pd 1833 11 will will MD cord-015365-iqdi99pd 1833 12 display display VB cord-015365-iqdi99pd 1833 13 the the DT cord-015365-iqdi99pd 1833 14 efficacy efficacy NN cord-015365-iqdi99pd 1833 15 of of IN cord-015365-iqdi99pd 1833 16 this this DT cord-015365-iqdi99pd 1833 17 treatment treatment NN cord-015365-iqdi99pd 1833 18 and and CC cord-015365-iqdi99pd 1833 19 the the DT cord-015365-iqdi99pd 1833 20 expected expect VBN cord-015365-iqdi99pd 1833 21 differences difference NNS cord-015365-iqdi99pd 1833 22 in in IN cord-015365-iqdi99pd 1833 23 transplantation transplantation NN cord-015365-iqdi99pd 1833 24 sites site NNS cord-015365-iqdi99pd 1833 25 . . . cord-015365-iqdi99pd 1834 1 Background background NN cord-015365-iqdi99pd 1834 2 . . . cord-015365-iqdi99pd 1835 1 Heart heart NN cord-015365-iqdi99pd 1835 2 failure failure NN cord-015365-iqdi99pd 1835 3 following follow VBG cord-015365-iqdi99pd 1835 4 acute acute JJ cord-015365-iqdi99pd 1835 5 myocardial myocardial JJ cord-015365-iqdi99pd 1835 6 infarction infarction NN cord-015365-iqdi99pd 1835 7 ( ( -LRB- cord-015365-iqdi99pd 1835 8 AMI AMI NNP cord-015365-iqdi99pd 1835 9 ) ) -RRB- cord-015365-iqdi99pd 1835 10 is be VBZ cord-015365-iqdi99pd 1835 11 a a DT cord-015365-iqdi99pd 1835 12 major major JJ cord-015365-iqdi99pd 1835 13 cause cause NN cord-015365-iqdi99pd 1835 14 of of IN cord-015365-iqdi99pd 1835 15 morbidity morbidity NN cord-015365-iqdi99pd 1835 16 and and CC cord-015365-iqdi99pd 1835 17 mortality mortality NN cord-015365-iqdi99pd 1835 18 . . . cord-015365-iqdi99pd 1836 1 Our -PRON- PRP$ cord-015365-iqdi99pd 1836 2 previous previous JJ cord-015365-iqdi99pd 1836 3 observation observation NN cord-015365-iqdi99pd 1836 4 that that IN cord-015365-iqdi99pd 1836 5 injection injection NN cord-015365-iqdi99pd 1836 6 of of IN cord-015365-iqdi99pd 1836 7 apoptotic apoptotic JJ cord-015365-iqdi99pd 1836 8 peripheral peripheral JJ cord-015365-iqdi99pd 1836 9 blood blood NN cord-015365-iqdi99pd 1836 10 mononuclear mononuclear NN cord-015365-iqdi99pd 1836 11 cells cell NNS cord-015365-iqdi99pd 1836 12 ( ( -LRB- cord-015365-iqdi99pd 1836 13 PBMC PBMC NNP cord-015365-iqdi99pd 1836 14 ) ) -RRB- cord-015365-iqdi99pd 1836 15 was be VBD cord-015365-iqdi99pd 1836 16 able able JJ cord-015365-iqdi99pd 1836 17 to to TO cord-015365-iqdi99pd 1836 18 restore restore VB cord-015365-iqdi99pd 1836 19 cardiac cardiac JJ cord-015365-iqdi99pd 1836 20 function function NN cord-015365-iqdi99pd 1836 21 in in IN cord-015365-iqdi99pd 1836 22 a a DT cord-015365-iqdi99pd 1836 23 rat rat NN cord-015365-iqdi99pd 1836 24 acute acute JJ cord-015365-iqdi99pd 1836 25 ischaemia ischaemia NN cord-015365-iqdi99pd 1836 26 model model NN cord-015365-iqdi99pd 1836 27 prompted prompt VBD cord-015365-iqdi99pd 1836 28 us -PRON- PRP cord-015365-iqdi99pd 1836 29 to to TO cord-015365-iqdi99pd 1836 30 study study VB cord-015365-iqdi99pd 1836 31 the the DT cord-015365-iqdi99pd 1836 32 effect effect NN cord-015365-iqdi99pd 1836 33 of of IN cord-015365-iqdi99pd 1836 34 soluble soluble JJ cord-015365-iqdi99pd 1836 35 factors factor NNS cord-015365-iqdi99pd 1836 36 derived derive VBN cord-015365-iqdi99pd 1836 37 from from IN cord-015365-iqdi99pd 1836 38 apoptotic apoptotic JJ cord-015365-iqdi99pd 1836 39 PBMC PBMC NNP cord-015365-iqdi99pd 1836 40 on on IN cord-015365-iqdi99pd 1836 41 ventricular ventricular JJ cord-015365-iqdi99pd 1836 42 remodelling remodelling NN cord-015365-iqdi99pd 1836 43 after after IN cord-015365-iqdi99pd 1836 44 AMI AMI NNP cord-015365-iqdi99pd 1836 45 . . . cord-015365-iqdi99pd 1837 1 Methods method NNS cord-015365-iqdi99pd 1837 2 . . . cord-015365-iqdi99pd 1838 1 Cell cell NN cord-015365-iqdi99pd 1838 2 culture culture NN cord-015365-iqdi99pd 1838 3 supernatants supernatant NNS cord-015365-iqdi99pd 1838 4 derived derive VBN cord-015365-iqdi99pd 1838 5 from from IN cord-015365-iqdi99pd 1838 6 irradiated irradiate VBN cord-015365-iqdi99pd 1838 7 apoptotic apoptotic JJ cord-015365-iqdi99pd 1838 8 peripheral peripheral JJ cord-015365-iqdi99pd 1838 9 blood blood NN cord-015365-iqdi99pd 1838 10 mononuclear mononuclear NN cord-015365-iqdi99pd 1838 11 cells cell NNS cord-015365-iqdi99pd 1838 12 ( ( -LRB- cord-015365-iqdi99pd 1838 13 APOSEC APOSEC NNP cord-015365-iqdi99pd 1838 14 ) ) -RRB- cord-015365-iqdi99pd 1838 15 were be VBD cord-015365-iqdi99pd 1838 16 collected collect VBN cord-015365-iqdi99pd 1838 17 and and CC cord-015365-iqdi99pd 1838 18 injected inject VBN cord-015365-iqdi99pd 1838 19 as as IN cord-015365-iqdi99pd 1838 20 a a DT cord-015365-iqdi99pd 1838 21 single single JJ cord-015365-iqdi99pd 1838 22 dose dose NN cord-015365-iqdi99pd 1838 23 intravenously intravenously RB cord-015365-iqdi99pd 1838 24 after after IN cord-015365-iqdi99pd 1838 25 myocardial myocardial JJ cord-015365-iqdi99pd 1838 26 infarction infarction NN cord-015365-iqdi99pd 1838 27 in in IN cord-015365-iqdi99pd 1838 28 an an DT cord-015365-iqdi99pd 1838 29 experimental experimental JJ cord-015365-iqdi99pd 1838 30 AMI AMI NNP cord-015365-iqdi99pd 1838 31 rat rat NN cord-015365-iqdi99pd 1838 32 model model NN cord-015365-iqdi99pd 1838 33 and and CC cord-015365-iqdi99pd 1838 34 in in IN cord-015365-iqdi99pd 1838 35 a a DT cord-015365-iqdi99pd 1838 36 porcine porcine JJ cord-015365-iqdi99pd 1838 37 reperfused reperfuse VBN cord-015365-iqdi99pd 1838 38 AMI AMI NNP cord-015365-iqdi99pd 1838 39 model model NN cord-015365-iqdi99pd 1838 40 . . . cord-015365-iqdi99pd 1839 1 MRI MRI NNP cord-015365-iqdi99pd 1839 2 and and CC cord-015365-iqdi99pd 1839 3 echocardiography echocardiography NN cord-015365-iqdi99pd 1839 4 were be VBD cord-015365-iqdi99pd 1839 5 used use VBN cord-015365-iqdi99pd 1839 6 to to TO cord-015365-iqdi99pd 1839 7 quantitate quantitate VB cord-015365-iqdi99pd 1839 8 cardiac cardiac JJ cord-015365-iqdi99pd 1839 9 function function NN cord-015365-iqdi99pd 1839 10 . . . cord-015365-iqdi99pd 1840 1 Immunohistology Immunohistology NNP cord-015365-iqdi99pd 1840 2 and and CC cord-015365-iqdi99pd 1840 3 flowcytometry flowcytometry NNP cord-015365-iqdi99pd 1840 4 were be VBD cord-015365-iqdi99pd 1840 5 used use VBN cord-015365-iqdi99pd 1840 6 to to TO cord-015365-iqdi99pd 1840 7 analyse analyse VB cord-015365-iqdi99pd 1840 8 the the DT cord-015365-iqdi99pd 1840 9 cellular cellular JJ cord-015365-iqdi99pd 1840 10 components component NNS cord-015365-iqdi99pd 1840 11 . . . cord-015365-iqdi99pd 1841 1 Analysis analysis NN cord-015365-iqdi99pd 1841 2 of of IN cord-015365-iqdi99pd 1841 3 soluble soluble JJ cord-015365-iqdi99pd 1841 4 factors factor NNS cord-015365-iqdi99pd 1841 5 present present JJ cord-015365-iqdi99pd 1841 6 in in IN cord-015365-iqdi99pd 1841 7 APOSEC APOSEC NNP cord-015365-iqdi99pd 1841 8 was be VBD cord-015365-iqdi99pd 1841 9 performed perform VBN cord-015365-iqdi99pd 1841 10 with with IN cord-015365-iqdi99pd 1841 11 proteome proteome NN cord-015365-iqdi99pd 1841 12 membrane membrane NN cord-015365-iqdi99pd 1841 13 arrays array NNS cord-015365-iqdi99pd 1841 14 and and CC cord-015365-iqdi99pd 1841 15 activation activation NN cord-015365-iqdi99pd 1841 16 of of IN cord-015365-iqdi99pd 1841 17 signalling signal VBG cord-015365-iqdi99pd 1841 18 cascades cascade NNS cord-015365-iqdi99pd 1841 19 in in IN cord-015365-iqdi99pd 1841 20 human human JJ cord-015365-iqdi99pd 1841 21 cardiomyocytes cardiomyocyte NNS cord-015365-iqdi99pd 1841 22 by by IN cord-015365-iqdi99pd 1841 23 APOSEC APOSEC NNP cord-015365-iqdi99pd 1841 24 in in IN cord-015365-iqdi99pd 1841 25 vitro vitro FW cord-015365-iqdi99pd 1841 26 was be VBD cord-015365-iqdi99pd 1841 27 studied study VBN cord-015365-iqdi99pd 1841 28 by by IN cord-015365-iqdi99pd 1841 29 immunoblot immunoblot NNP cord-015365-iqdi99pd 1841 30 - - HYPH cord-015365-iqdi99pd 1841 31 analysis analysis NN cord-015365-iqdi99pd 1841 32 . . . cord-015365-iqdi99pd 1842 1 Results result NNS cord-015365-iqdi99pd 1842 2 . . . cord-015365-iqdi99pd 1843 1 Intravenous intravenous JJ cord-015365-iqdi99pd 1843 2 administration administration NN cord-015365-iqdi99pd 1843 3 of of IN cord-015365-iqdi99pd 1843 4 APOSEC APOSEC NNP cord-015365-iqdi99pd 1843 5 resulted result VBD cord-015365-iqdi99pd 1843 6 in in IN cord-015365-iqdi99pd 1843 7 a a DT cord-015365-iqdi99pd 1843 8 reduction reduction NN cord-015365-iqdi99pd 1843 9 of of IN cord-015365-iqdi99pd 1843 10 scar scar NN cord-015365-iqdi99pd 1843 11 extension extension NN cord-015365-iqdi99pd 1843 12 in in IN cord-015365-iqdi99pd 1843 13 both both DT cord-015365-iqdi99pd 1843 14 models model NNS cord-015365-iqdi99pd 1843 15 . . . cord-015365-iqdi99pd 1844 1 Hearts heart NNS cord-015365-iqdi99pd 1844 2 explanted explante VBN cord-015365-iqdi99pd 1844 3 from from IN cord-015365-iqdi99pd 1844 4 animals animal NNS cord-015365-iqdi99pd 1844 5 infused infuse VBN cord-015365-iqdi99pd 1844 6 with with IN cord-015365-iqdi99pd 1844 7 APOSEC APOSEC NNP cord-015365-iqdi99pd 1844 8 evidenced evidence VBN cord-015365-iqdi99pd 1844 9 less less RBR cord-015365-iqdi99pd 1844 10 myocardial myocardial JJ cord-015365-iqdi99pd 1844 11 necrosis necrosis NN cord-015365-iqdi99pd 1844 12 after after IN cord-015365-iqdi99pd 1844 13 24 24 CD cord-015365-iqdi99pd 1844 14 hrs hrs NN cord-015365-iqdi99pd 1844 15 . . . cord-015365-iqdi99pd 1845 1 Troponin Troponin NNP cord-015365-iqdi99pd 1845 2 - - : cord-015365-iqdi99pd 1845 3 I -PRON- PRP cord-015365-iqdi99pd 1845 4 release release NN cord-015365-iqdi99pd 1845 5 was be VBD cord-015365-iqdi99pd 1845 6 less less JJR cord-015365-iqdi99pd 1845 7 than than IN cord-015365-iqdi99pd 1845 8 in in IN cord-015365-iqdi99pd 1845 9 animals animal NNS cord-015365-iqdi99pd 1845 10 treated treat VBN cord-015365-iqdi99pd 1845 11 with with IN cord-015365-iqdi99pd 1845 12 medium medium NN cord-015365-iqdi99pd 1845 13 as as IN cord-015365-iqdi99pd 1845 14 control control NN cord-015365-iqdi99pd 1845 15 . . . cord-015365-iqdi99pd 1846 1 In in IN cord-015365-iqdi99pd 1846 2 the the DT cord-015365-iqdi99pd 1846 3 porcine porcine JJ cord-015365-iqdi99pd 1846 4 AMI AMI NNP cord-015365-iqdi99pd 1846 5 model model NN cord-015365-iqdi99pd 1846 6 APOSEC APOSEC NNP cord-015365-iqdi99pd 1846 7 led lead VBD cord-015365-iqdi99pd 1846 8 to to IN cord-015365-iqdi99pd 1846 9 an an DT cord-015365-iqdi99pd 1846 10 improvement improvement NN cord-015365-iqdi99pd 1846 11 of of IN cord-015365-iqdi99pd 1846 12 ejection ejection NN cord-015365-iqdi99pd 1846 13 fraction fraction NN cord-015365-iqdi99pd 1846 14 ( ( -LRB- cord-015365-iqdi99pd 1846 15 57.0 57.0 CD cord-015365-iqdi99pd 1846 16 % % NN cord-015365-iqdi99pd 1846 17 vs. vs. IN cord-015365-iqdi99pd 1846 18 40.5 40.5 CD cord-015365-iqdi99pd 1846 19 % % NN cord-015365-iqdi99pd 1846 20 , , , cord-015365-iqdi99pd 1846 21 p p NN cord-015365-iqdi99pd 1846 22 < < XX cord-015365-iqdi99pd 1846 23 0.01 0.01 CD cord-015365-iqdi99pd 1846 24 ) ) -RRB- cord-015365-iqdi99pd 1846 25 , , , cord-015365-iqdi99pd 1846 26 cardiac cardiac JJ cord-015365-iqdi99pd 1846 27 output output NN cord-015365-iqdi99pd 1846 28 ( ( -LRB- cord-015365-iqdi99pd 1846 29 4.0 4.0 CD cord-015365-iqdi99pd 1846 30 vs. vs. NN cord-015365-iqdi99pd 1846 31 2.4 2.4 CD cord-015365-iqdi99pd 1846 32 l l NN cord-015365-iqdi99pd 1846 33 / / SYM cord-015365-iqdi99pd 1846 34 min min NNP cord-015365-iqdi99pd 1846 35 . . NNP cord-015365-iqdi99pd 1846 36 , , , cord-015365-iqdi99pd 1846 37 p p NN cord-015365-iqdi99pd 1846 38 < < XX cord-015365-iqdi99pd 1846 39 0.001 0.001 CD cord-015365-iqdi99pd 1846 40 ) ) -RRB- cord-015365-iqdi99pd 1846 41 and and CC cord-015365-iqdi99pd 1846 42 a a DT cord-015365-iqdi99pd 1846 43 reduced reduce VBN cord-015365-iqdi99pd 1846 44 infarction infarction NN cord-015365-iqdi99pd 1846 45 size size NN cord-015365-iqdi99pd 1846 46 ( ( -LRB- cord-015365-iqdi99pd 1846 47 12.6 12.6 CD cord-015365-iqdi99pd 1846 48 % % NN cord-015365-iqdi99pd 1846 49 vs. vs. CC cord-015365-iqdi99pd 1846 50 6.9 6.9 CD cord-015365-iqdi99pd 1846 51 % % NN cord-015365-iqdi99pd 1846 52 , , , cord-015365-iqdi99pd 1846 53 p p NN cord-015365-iqdi99pd 1846 54 < < XX cord-015365-iqdi99pd 1846 55 0.02 0.02 CD cord-015365-iqdi99pd 1846 56 ) ) -RRB- cord-015365-iqdi99pd 1846 57 as as IN cord-015365-iqdi99pd 1846 58 determined determine VBN cord-015365-iqdi99pd 1846 59 by by IN cord-015365-iqdi99pd 1846 60 MRI MRI NNP cord-015365-iqdi99pd 1846 61 . . . cord-015365-iqdi99pd 1847 1 Administration Administration NNP cord-015365-iqdi99pd 1847 2 of of IN cord-015365-iqdi99pd 1847 3 APOSEC APOSEC NNP cord-015365-iqdi99pd 1847 4 in in IN cord-015365-iqdi99pd 1847 5 the the DT cord-015365-iqdi99pd 1847 6 rat rat NN cord-015365-iqdi99pd 1847 7 AMI AMI NNP cord-015365-iqdi99pd 1847 8 model model NN cord-015365-iqdi99pd 1847 9 caused cause VBD cord-015365-iqdi99pd 1847 10 increased increase VBN cord-015365-iqdi99pd 1847 11 presence presence NN cord-015365-iqdi99pd 1847 12 of of IN cord-015365-iqdi99pd 1847 13 CD68 CD68 NNP cord-015365-iqdi99pd 1847 14 þ þ NNP cord-015365-iqdi99pd 1847 15 macrophages macrophage NNS cord-015365-iqdi99pd 1847 16 and and CC cord-015365-iqdi99pd 1847 17 c c NN cord-015365-iqdi99pd 1847 18 - - HYPH cord-015365-iqdi99pd 1847 19 kitþ kitþ VBN cord-015365-iqdi99pd 1847 20 endothelial endothelial JJ cord-015365-iqdi99pd 1847 21 progenitor progenitor NN cord-015365-iqdi99pd 1847 22 cells cell NNS cord-015365-iqdi99pd 1847 23 ( ( -LRB- cord-015365-iqdi99pd 1847 24 EPC EPC NNP cord-015365-iqdi99pd 1847 25 ) ) -RRB- cord-015365-iqdi99pd 1847 26 in in IN cord-015365-iqdi99pd 1847 27 the the DT cord-015365-iqdi99pd 1847 28 infarcted infarcted JJ cord-015365-iqdi99pd 1847 29 myocardium myocardium NN cord-015365-iqdi99pd 1847 30 within within IN cord-015365-iqdi99pd 1847 31 72 72 CD cord-015365-iqdi99pd 1847 32 hrs hrs NN cord-015365-iqdi99pd 1847 33 . . . cord-015365-iqdi99pd 1848 1 Exposure exposure NN cord-015365-iqdi99pd 1848 2 of of IN cord-015365-iqdi99pd 1848 3 human human JJ cord-015365-iqdi99pd 1848 4 cardiomyocytes cardiomyocyte NNS cord-015365-iqdi99pd 1848 5 with with IN cord-015365-iqdi99pd 1848 6 APOSEC APOSEC NNP cord-015365-iqdi99pd 1848 7 in in IN cord-015365-iqdi99pd 1848 8 vitro vitro FW cord-015365-iqdi99pd 1848 9 triggered trigger VBN cord-015365-iqdi99pd 1848 10 activation activation NN cord-015365-iqdi99pd 1848 11 of of IN cord-015365-iqdi99pd 1848 12 pro pro JJ cord-015365-iqdi99pd 1848 13 - - JJ cord-015365-iqdi99pd 1848 14 survival survival JJ cord-015365-iqdi99pd 1848 15 signalling signalling NN cord-015365-iqdi99pd 1848 16 - - HYPH cord-015365-iqdi99pd 1848 17 cascades cascade NNS cord-015365-iqdi99pd 1848 18 ( ( -LRB- cord-015365-iqdi99pd 1848 19 AKT AKT NNP cord-015365-iqdi99pd 1848 20 , , , cord-015365-iqdi99pd 1848 21 p38 p38 NN cord-015365-iqdi99pd 1848 22 MAPK MAPK NNP cord-015365-iqdi99pd 1848 23 , , , cord-015365-iqdi99pd 1848 24 Erk1/2 Erk1/2 NNP cord-015365-iqdi99pd 1848 25 , , , cord-015365-iqdi99pd 1848 26 CREB CREB NNP cord-015365-iqdi99pd 1848 27 , , , cord-015365-iqdi99pd 1848 28 c c NNP cord-015365-iqdi99pd 1848 29 - - : cord-015365-iqdi99pd 1848 30 Jun Jun NNP cord-015365-iqdi99pd 1848 31 ) ) -RRB- cord-015365-iqdi99pd 1848 32 and and CC cord-015365-iqdi99pd 1848 33 anti anti JJ cord-015365-iqdi99pd 1848 34 - - JJ cord-015365-iqdi99pd 1848 35 apoptotic apoptotic JJ cord-015365-iqdi99pd 1848 36 gene gene NN cord-015365-iqdi99pd 1848 37 products product NNS cord-015365-iqdi99pd 1848 38 ( ( -LRB- cord-015365-iqdi99pd 1848 39 Bcl-2 Bcl-2 NNP cord-015365-iqdi99pd 1848 40 , , , cord-015365-iqdi99pd 1848 41 BAG1 BAG1 NNP cord-015365-iqdi99pd 1848 42 ) ) -RRB- cord-015365-iqdi99pd 1848 43 . . . cord-015365-iqdi99pd 1849 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1849 2 . . . cord-015365-iqdi99pd 1850 1 Intravenous intravenous JJ cord-015365-iqdi99pd 1850 2 infusion infusion NN cord-015365-iqdi99pd 1850 3 of of IN cord-015365-iqdi99pd 1850 4 APOSEC APOSEC NNP cord-015365-iqdi99pd 1850 5 attenuated attenuated JJ cord-015365-iqdi99pd 1850 6 myocardial myocardial JJ cord-015365-iqdi99pd 1850 7 remodelling remodelling NN cord-015365-iqdi99pd 1850 8 in in IN cord-015365-iqdi99pd 1850 9 both both DT cord-015365-iqdi99pd 1850 10 models model NNS cord-015365-iqdi99pd 1850 11 of of IN cord-015365-iqdi99pd 1850 12 experimental experimental JJ cord-015365-iqdi99pd 1850 13 AMI AMI NNP cord-015365-iqdi99pd 1850 14 . . . cord-015365-iqdi99pd 1851 1 This this DT cord-015365-iqdi99pd 1851 2 effect effect NN cord-015365-iqdi99pd 1851 3 seems seem VBZ cord-015365-iqdi99pd 1851 4 to to TO cord-015365-iqdi99pd 1851 5 be be VB cord-015365-iqdi99pd 1851 6 due due JJ cord-015365-iqdi99pd 1851 7 to to IN cord-015365-iqdi99pd 1851 8 the the DT cord-015365-iqdi99pd 1851 9 activation activation NN cord-015365-iqdi99pd 1851 10 of of IN cord-015365-iqdi99pd 1851 11 pro pro JJ cord-015365-iqdi99pd 1851 12 - - JJ cord-015365-iqdi99pd 1851 13 survival survival JJ cord-015365-iqdi99pd 1851 14 signalling signalling NN cord-015365-iqdi99pd 1851 15 cascades cascade NNS cord-015365-iqdi99pd 1851 16 in in IN cord-015365-iqdi99pd 1851 17 the the DT cord-015365-iqdi99pd 1851 18 affected affect VBN cord-015365-iqdi99pd 1851 19 cardiomyocytes cardiomyocyte NNS cord-015365-iqdi99pd 1851 20 and and CC cord-015365-iqdi99pd 1851 21 to to IN cord-015365-iqdi99pd 1851 22 a a DT cord-015365-iqdi99pd 1851 23 higher high JJR cord-015365-iqdi99pd 1851 24 presence presence NN cord-015365-iqdi99pd 1851 25 of of IN cord-015365-iqdi99pd 1851 26 regenerative regenerative JJ cord-015365-iqdi99pd 1851 27 cells cell NNS cord-015365-iqdi99pd 1851 28 ( ( -LRB- cord-015365-iqdi99pd 1851 29 EPCs epc NNS cord-015365-iqdi99pd 1851 30 , , , cord-015365-iqdi99pd 1851 31 macrophages macrophage NNS cord-015365-iqdi99pd 1851 32 ) ) -RRB- cord-015365-iqdi99pd 1851 33 within within IN cord-015365-iqdi99pd 1851 34 the the DT cord-015365-iqdi99pd 1851 35 ischaemic ischaemic JJ cord-015365-iqdi99pd 1851 36 tissue tissue NN cord-015365-iqdi99pd 1851 37 . . . cord-015365-iqdi99pd 1852 1 APOSEC APOSEC NNP cord-015365-iqdi99pd 1852 2 represents represent VBZ cord-015365-iqdi99pd 1852 3 a a DT cord-015365-iqdi99pd 1852 4 " " `` cord-015365-iqdi99pd 1852 5 biological biological JJ cord-015365-iqdi99pd 1852 6 " " '' cord-015365-iqdi99pd 1852 7 which which WDT cord-015365-iqdi99pd 1852 8 prevents prevent VBZ cord-015365-iqdi99pd 1852 9 myocardial myocardial JJ cord-015365-iqdi99pd 1852 10 infarction infarction NN cord-015365-iqdi99pd 1852 11 by by IN cord-015365-iqdi99pd 1852 12 causing cause VBG cord-015365-iqdi99pd 1852 13 peri peri JJ cord-015365-iqdi99pd 1852 14 - - HYPH cord-015365-iqdi99pd 1852 15 infarct infarct NN cord-015365-iqdi99pd 1852 16 conditioning conditioning NN cord-015365-iqdi99pd 1852 17 and and CC cord-015365-iqdi99pd 1852 18 stimulation stimulation NN cord-015365-iqdi99pd 1852 19 of of IN cord-015365-iqdi99pd 1852 20 regenerative regenerative JJ cord-015365-iqdi99pd 1852 21 effects effect NNS cord-015365-iqdi99pd 1852 22 in in IN cord-015365-iqdi99pd 1852 23 the the DT cord-015365-iqdi99pd 1852 24 hypoxic hypoxic JJ cord-015365-iqdi99pd 1852 25 myocardium myocardium NN cord-015365-iqdi99pd 1852 26 . . . cord-015365-iqdi99pd 1853 1 Anti anti JJ cord-015365-iqdi99pd 1853 2 - - JJ cord-015365-iqdi99pd 1853 3 thymocyte thymocyte JJ cord-015365-iqdi99pd 1853 4 globulin globulin NN cord-015365-iqdi99pd 1853 5 ( ( -LRB- cord-015365-iqdi99pd 1853 6 ATG ATG NNP cord-015365-iqdi99pd 1853 7 ) ) -RRB- cord-015365-iqdi99pd 1853 8 reduces reduce VBZ cord-015365-iqdi99pd 1853 9 damage damage NN cord-015365-iqdi99pd 1853 10 caused cause VBN cord-015365-iqdi99pd 1853 11 by by IN cord-015365-iqdi99pd 1853 12 ischaemia ischaemia NN cord-015365-iqdi99pd 1853 13 and and CC cord-015365-iqdi99pd 1853 14 preserves preserve VBZ cord-015365-iqdi99pd 1853 15 cardiac cardiac JJ cord-015365-iqdi99pd 1853 16 function function NN cord-015365-iqdi99pd 1853 17 after after IN cord-015365-iqdi99pd 1853 18 experimental experimental JJ cord-015365-iqdi99pd 1853 19 myocardial myocardial JJ cord-015365-iqdi99pd 1853 20 infarction infarction NN cord-015365-iqdi99pd 1853 21 Background Background NNP cord-015365-iqdi99pd 1853 22 . . . cord-015365-iqdi99pd 1854 1 Myocardial myocardial JJ cord-015365-iqdi99pd 1854 2 infarction infarction NN cord-015365-iqdi99pd 1854 3 ( ( -LRB- cord-015365-iqdi99pd 1854 4 MI MI NNP cord-015365-iqdi99pd 1854 5 ) ) -RRB- cord-015365-iqdi99pd 1854 6 is be VBZ cord-015365-iqdi99pd 1854 7 one one CD cord-015365-iqdi99pd 1854 8 of of IN cord-015365-iqdi99pd 1854 9 the the DT cord-015365-iqdi99pd 1854 10 leading lead VBG cord-015365-iqdi99pd 1854 11 causes cause NNS cord-015365-iqdi99pd 1854 12 of of IN cord-015365-iqdi99pd 1854 13 death death NN cord-015365-iqdi99pd 1854 14 in in IN cord-015365-iqdi99pd 1854 15 the the DT cord-015365-iqdi99pd 1854 16 western western JJ cord-015365-iqdi99pd 1854 17 world world NN cord-015365-iqdi99pd 1854 18 . . . cord-015365-iqdi99pd 1855 1 Consequent consequent JJ cord-015365-iqdi99pd 1855 2 inflammatory inflammatory JJ cord-015365-iqdi99pd 1855 3 reactions reaction NNS cord-015365-iqdi99pd 1855 4 initiate initiate VBP cord-015365-iqdi99pd 1855 5 and and CC cord-015365-iqdi99pd 1855 6 sustain sustain VBP cord-015365-iqdi99pd 1855 7 remodeling remodeling NN cord-015365-iqdi99pd 1855 8 of of IN cord-015365-iqdi99pd 1855 9 the the DT cord-015365-iqdi99pd 1855 10 damaged damage VBN cord-015365-iqdi99pd 1855 11 myocardium myocardium NN cord-015365-iqdi99pd 1855 12 , , , cord-015365-iqdi99pd 1855 13 which which WDT cord-015365-iqdi99pd 1855 14 can can MD cord-015365-iqdi99pd 1855 15 worsen worsen VB cord-015365-iqdi99pd 1855 16 the the DT cord-015365-iqdi99pd 1855 17 outcome outcome NN cord-015365-iqdi99pd 1855 18 additionally additionally RB cord-015365-iqdi99pd 1855 19 . . . cord-015365-iqdi99pd 1856 1 Our -PRON- PRP$ cord-015365-iqdi99pd 1856 2 previous previous JJ cord-015365-iqdi99pd 1856 3 findings finding NNS cord-015365-iqdi99pd 1856 4 suggest suggest VBP cord-015365-iqdi99pd 1856 5 that that IN cord-015365-iqdi99pd 1856 6 apoptotic apoptotic JJ cord-015365-iqdi99pd 1856 7 peripheral peripheral JJ cord-015365-iqdi99pd 1856 8 blood blood NN cord-015365-iqdi99pd 1856 9 mononuclear mononuclear NN cord-015365-iqdi99pd 1856 10 cells cell NNS cord-015365-iqdi99pd 1856 11 ( ( -LRB- cord-015365-iqdi99pd 1856 12 PBMCs pbmc NNS cord-015365-iqdi99pd 1856 13 ) ) -RRB- cord-015365-iqdi99pd 1856 14 , , , cord-015365-iqdi99pd 1856 15 injected inject VBN cord-015365-iqdi99pd 1856 16 intravenously intravenously RB cord-015365-iqdi99pd 1856 17 after after IN cord-015365-iqdi99pd 1856 18 MI MI NNP cord-015365-iqdi99pd 1856 19 in in IN cord-015365-iqdi99pd 1856 20 rats rat NNS cord-015365-iqdi99pd 1856 21 , , , cord-015365-iqdi99pd 1856 22 can can MD cord-015365-iqdi99pd 1856 23 attenuate attenuate VB cord-015365-iqdi99pd 1856 24 inflammation inflammation NN cord-015365-iqdi99pd 1856 25 and and CC cord-015365-iqdi99pd 1856 26 subsequently subsequently RB cord-015365-iqdi99pd 1856 27 improve improve VB cord-015365-iqdi99pd 1856 28 cardiac cardiac JJ cord-015365-iqdi99pd 1856 29 function function NN cord-015365-iqdi99pd 1856 30 after after IN cord-015365-iqdi99pd 1856 31 MI MI NNP cord-015365-iqdi99pd 1856 32 . . . cord-015365-iqdi99pd 1857 1 In in IN cord-015365-iqdi99pd 1857 2 this this DT cord-015365-iqdi99pd 1857 3 study study NN cord-015365-iqdi99pd 1857 4 we -PRON- PRP cord-015365-iqdi99pd 1857 5 sought seek VBD cord-015365-iqdi99pd 1857 6 to to TO cord-015365-iqdi99pd 1857 7 investigate investigate VB cord-015365-iqdi99pd 1857 8 , , , cord-015365-iqdi99pd 1857 9 if if IN cord-015365-iqdi99pd 1857 10 anti anti JJ cord-015365-iqdi99pd 1857 11 - - JJ cord-015365-iqdi99pd 1857 12 thymocyte thymocyte JJ cord-015365-iqdi99pd 1857 13 globulin globulin NN cord-015365-iqdi99pd 1857 14 ( ( -LRB- cord-015365-iqdi99pd 1857 15 ATG ATG NNP cord-015365-iqdi99pd 1857 16 ) ) -RRB- cord-015365-iqdi99pd 1857 17 as as IN cord-015365-iqdi99pd 1857 18 a a DT cord-015365-iqdi99pd 1857 19 therapeutic therapeutic JJ cord-015365-iqdi99pd 1857 20 agent agent NN cord-015365-iqdi99pd 1857 21 inducing induce VBG cord-015365-iqdi99pd 1857 22 apoptosis apoptosis NN cord-015365-iqdi99pd 1857 23 in in IN cord-015365-iqdi99pd 1857 24 white white JJ cord-015365-iqdi99pd 1857 25 blood blood NN cord-015365-iqdi99pd 1857 26 cells cell NNS cord-015365-iqdi99pd 1857 27 , , , cord-015365-iqdi99pd 1857 28 evidences evidence NNS cord-015365-iqdi99pd 1857 29 similar similar JJ cord-015365-iqdi99pd 1857 30 effects effect NNS cord-015365-iqdi99pd 1857 31 after after IN cord-015365-iqdi99pd 1857 32 experimental experimental JJ cord-015365-iqdi99pd 1857 33 MI MI NNP cord-015365-iqdi99pd 1857 34 in in IN cord-015365-iqdi99pd 1857 35 rats rat NNS cord-015365-iqdi99pd 1857 36 . . . cord-015365-iqdi99pd 1858 1 Methods method NNS cord-015365-iqdi99pd 1858 2 . . . cord-015365-iqdi99pd 1859 1 To to TO cord-015365-iqdi99pd 1859 2 study study VB cord-015365-iqdi99pd 1859 3 effects effect NNS cord-015365-iqdi99pd 1859 4 of of IN cord-015365-iqdi99pd 1859 5 ATG ATG NNP cord-015365-iqdi99pd 1859 6 in in IN cord-015365-iqdi99pd 1859 7 vitro vitro FW cord-015365-iqdi99pd 1859 8 , , , cord-015365-iqdi99pd 1859 9 we -PRON- PRP cord-015365-iqdi99pd 1859 10 incubated incubate VBD cord-015365-iqdi99pd 1859 11 whole whole JJ cord-015365-iqdi99pd 1859 12 blood blood NN cord-015365-iqdi99pd 1859 13 and and CC cord-015365-iqdi99pd 1859 14 PBMC PBMC NNP cord-015365-iqdi99pd 1859 15 cell cell NN cord-015365-iqdi99pd 1859 16 cultures culture NNS cord-015365-iqdi99pd 1859 17 with with IN cord-015365-iqdi99pd 1859 18 this this DT cord-015365-iqdi99pd 1859 19 polyclonal polyclonal JJ cord-015365-iqdi99pd 1859 20 antibody antibody NN cord-015365-iqdi99pd 1859 21 for for IN cord-015365-iqdi99pd 1859 22 24 24 CD cord-015365-iqdi99pd 1859 23 hours hour NNS cord-015365-iqdi99pd 1859 24 . . . cord-015365-iqdi99pd 1860 1 ELISA ELISA NNP cord-015365-iqdi99pd 1860 2 was be VBD cord-015365-iqdi99pd 1860 3 utilized utilize VBN cord-015365-iqdi99pd 1860 4 to to TO cord-015365-iqdi99pd 1860 5 assess assess VB cord-015365-iqdi99pd 1860 6 changes change NNS cord-015365-iqdi99pd 1860 7 in in IN cord-015365-iqdi99pd 1860 8 the the DT cord-015365-iqdi99pd 1860 9 secretion secretion NN cord-015365-iqdi99pd 1860 10 profile profile NN cord-015365-iqdi99pd 1860 11 of of IN cord-015365-iqdi99pd 1860 12 various various JJ cord-015365-iqdi99pd 1860 13 cytokines cytokine NNS cord-015365-iqdi99pd 1860 14 . . . cord-015365-iqdi99pd 1861 1 Furthermore furthermore RB cord-015365-iqdi99pd 1861 2 , , , cord-015365-iqdi99pd 1861 3 we -PRON- PRP cord-015365-iqdi99pd 1861 4 conducted conduct VBD cord-015365-iqdi99pd 1861 5 an an DT cord-015365-iqdi99pd 1861 6 in in IN cord-015365-iqdi99pd 1861 7 vivo vivo NN cord-015365-iqdi99pd 1861 8 study study NN cord-015365-iqdi99pd 1861 9 in in IN cord-015365-iqdi99pd 1861 10 an an DT cord-015365-iqdi99pd 1861 11 experimental experimental JJ cord-015365-iqdi99pd 1861 12 rat rat NN cord-015365-iqdi99pd 1861 13 model model NN cord-015365-iqdi99pd 1861 14 of of IN cord-015365-iqdi99pd 1861 15 myocardial myocardial JJ cord-015365-iqdi99pd 1861 16 infarction infarction NN cord-015365-iqdi99pd 1861 17 . . . cord-015365-iqdi99pd 1862 1 Rodents rodent NNS cord-015365-iqdi99pd 1862 2 were be VBD cord-015365-iqdi99pd 1862 3 injected inject VBN cord-015365-iqdi99pd 1862 4 with with IN cord-015365-iqdi99pd 1862 5 ATG ATG NNP cord-015365-iqdi99pd 1862 6 ( ( -LRB- cord-015365-iqdi99pd 1862 7 10 10 CD cord-015365-iqdi99pd 1862 8 mg mg NN cord-015365-iqdi99pd 1862 9 / / SYM cord-015365-iqdi99pd 1862 10 rat rat NN cord-015365-iqdi99pd 1862 11 ) ) -RRB- cord-015365-iqdi99pd 1862 12 after after IN cord-015365-iqdi99pd 1862 13 ligation ligation NN cord-015365-iqdi99pd 1862 14 of of IN cord-015365-iqdi99pd 1862 15 the the DT cord-015365-iqdi99pd 1862 16 left left JJ cord-015365-iqdi99pd 1862 17 anterior anterior JJ cord-015365-iqdi99pd 1862 18 descending descend VBG cord-015365-iqdi99pd 1862 19 ( ( -LRB- cord-015365-iqdi99pd 1862 20 LAD lad NN cord-015365-iqdi99pd 1862 21 ) ) -RRB- cord-015365-iqdi99pd 1862 22 artery artery NN cord-015365-iqdi99pd 1862 23 . . . cord-015365-iqdi99pd 1863 1 Untreated untreated JJ cord-015365-iqdi99pd 1863 2 and and CC cord-015365-iqdi99pd 1863 3 sham sham NN cord-015365-iqdi99pd 1863 4 operated operate VBN cord-015365-iqdi99pd 1863 5 animals animal NNS cord-015365-iqdi99pd 1863 6 served serve VBD cord-015365-iqdi99pd 1863 7 as as IN cord-015365-iqdi99pd 1863 8 controls control NNS cord-015365-iqdi99pd 1863 9 . . . cord-015365-iqdi99pd 1864 1 Short short JJ cord-015365-iqdi99pd 1864 2 term term NN cord-015365-iqdi99pd 1864 3 effects effect NNS cord-015365-iqdi99pd 1864 4 were be VBD cord-015365-iqdi99pd 1864 5 evaluated evaluate VBN cord-015365-iqdi99pd 1864 6 by by IN cord-015365-iqdi99pd 1864 7 immunohistology immunohistology NN cord-015365-iqdi99pd 1864 8 after after IN cord-015365-iqdi99pd 1864 9 three three CD cord-015365-iqdi99pd 1864 10 days day NNS cord-015365-iqdi99pd 1864 11 . . . cord-015365-iqdi99pd 1865 1 Echocardiography echocardiography NN cord-015365-iqdi99pd 1865 2 and and CC cord-015365-iqdi99pd 1865 3 assessment assessment NN cord-015365-iqdi99pd 1865 4 of of IN cord-015365-iqdi99pd 1865 5 infarction infarction NN cord-015365-iqdi99pd 1865 6 size size NN cord-015365-iqdi99pd 1865 7 by by IN cord-015365-iqdi99pd 1865 8 planimetry planimetry NNP cord-015365-iqdi99pd 1865 9 depicted depict VBD cord-015365-iqdi99pd 1865 10 the the DT cord-015365-iqdi99pd 1865 11 outcome outcome NN cord-015365-iqdi99pd 1865 12 after after IN cord-015365-iqdi99pd 1865 13 six six CD cord-015365-iqdi99pd 1865 14 weeks week NNS cord-015365-iqdi99pd 1865 15 . . . cord-015365-iqdi99pd 1866 1 Results result NNS cord-015365-iqdi99pd 1866 2 . . . cord-015365-iqdi99pd 1867 1 Cytokines cytokine NNS cord-015365-iqdi99pd 1867 2 and and CC cord-015365-iqdi99pd 1867 3 chemokines chemokine NNS cord-015365-iqdi99pd 1867 4 held hold VBD cord-015365-iqdi99pd 1867 5 responsible responsible JJ cord-015365-iqdi99pd 1867 6 for for IN cord-015365-iqdi99pd 1867 7 cardioprotective cardioprotective JJ cord-015365-iqdi99pd 1867 8 and and CC cord-015365-iqdi99pd 1867 9 neo neo JJ cord-015365-iqdi99pd 1867 10 - - JJ cord-015365-iqdi99pd 1867 11 angiogenic angiogenic JJ cord-015365-iqdi99pd 1867 12 effects effect NNS cord-015365-iqdi99pd 1867 13 ( ( -LRB- cord-015365-iqdi99pd 1867 14 e.g. e.g. RB cord-015365-iqdi99pd 1867 15 IL-1RA il-1ra NN cord-015365-iqdi99pd 1867 16 , , , cord-015365-iqdi99pd 1867 17 IL-8 IL-8 NNP cord-015365-iqdi99pd 1867 18 , , , cord-015365-iqdi99pd 1867 19 MCP-1 MCP-1 NNP cord-015365-iqdi99pd 1867 20 ) ) -RRB- cord-015365-iqdi99pd 1867 21 were be VBD cord-015365-iqdi99pd 1867 22 significantly significantly RB cord-015365-iqdi99pd 1867 23 elevated elevate VBN cord-015365-iqdi99pd 1867 24 in in IN cord-015365-iqdi99pd 1867 25 ATG ATG NNP cord-015365-iqdi99pd 1867 26 groups group NNS cord-015365-iqdi99pd 1867 27 over over IN cord-015365-iqdi99pd 1867 28 controls control NNS cord-015365-iqdi99pd 1867 29 in in IN cord-015365-iqdi99pd 1867 30 vitro vitro FW cord-015365-iqdi99pd 1867 31 . . . cord-015365-iqdi99pd 1868 1 Histology histology NN cord-015365-iqdi99pd 1868 2 of of IN cord-015365-iqdi99pd 1868 3 in in IN cord-015365-iqdi99pd 1868 4 vivo vivo NN cord-015365-iqdi99pd 1868 5 experiments experiment NNS cord-015365-iqdi99pd 1868 6 confirmed confirm VBD cord-015365-iqdi99pd 1868 7 these these DT cord-015365-iqdi99pd 1868 8 data datum NNS cord-015365-iqdi99pd 1868 9 , , , cord-015365-iqdi99pd 1868 10 as as IN cord-015365-iqdi99pd 1868 11 ATG ATG NNP cord-015365-iqdi99pd 1868 12 treated treat VBD cord-015365-iqdi99pd 1868 13 animals animal NNS cord-015365-iqdi99pd 1868 14 had have VBD cord-015365-iqdi99pd 1868 15 a a DT cord-015365-iqdi99pd 1868 16 reduced reduce VBN cord-015365-iqdi99pd 1868 17 area area NN cord-015365-iqdi99pd 1868 18 of of IN cord-015365-iqdi99pd 1868 19 necrosis necrosis NN cord-015365-iqdi99pd 1868 20 three three CD cord-015365-iqdi99pd 1868 21 days day NNS cord-015365-iqdi99pd 1868 22 after after IN cord-015365-iqdi99pd 1868 23 AMI AMI NNP cord-015365-iqdi99pd 1868 24 ( ( -LRB- cord-015365-iqdi99pd 1868 25 10.7 10.7 CD cord-015365-iqdi99pd 1868 26 % % NN cord-015365-iqdi99pd 1868 27 vs. vs. CC cord-015365-iqdi99pd 1868 28 20.6 20.6 CD cord-015365-iqdi99pd 1868 29 % % NN cord-015365-iqdi99pd 1868 30 ) ) -RRB- cord-015365-iqdi99pd 1868 31 , , , cord-015365-iqdi99pd 1868 32 smaller small JJR cord-015365-iqdi99pd 1868 33 infarct infarct NN cord-015365-iqdi99pd 1868 34 scars scar NNS cord-015365-iqdi99pd 1868 35 after after IN cord-015365-iqdi99pd 1868 36 six six CD cord-015365-iqdi99pd 1868 37 weeks week NNS cord-015365-iqdi99pd 1868 38 and and CC cord-015365-iqdi99pd 1868 39 an an DT cord-015365-iqdi99pd 1868 40 increased increase VBN cord-015365-iqdi99pd 1868 41 infiltration infiltration NN cord-015365-iqdi99pd 1868 42 of of IN cord-015365-iqdi99pd 1868 43 macrophages macrophage NNS cord-015365-iqdi99pd 1868 44 . . . cord-015365-iqdi99pd 1869 1 Echocardiography echocardiography NN cord-015365-iqdi99pd 1869 2 revealed reveal VBD cord-015365-iqdi99pd 1869 3 a a DT cord-015365-iqdi99pd 1869 4 treatment treatment NN cord-015365-iqdi99pd 1869 5 advantage advantage NN cord-015365-iqdi99pd 1869 6 of of IN cord-015365-iqdi99pd 1869 7 ATG ATG NNP cord-015365-iqdi99pd 1869 8 , , , cord-015365-iqdi99pd 1869 9 as as IN cord-015365-iqdi99pd 1869 10 rodents rodent NNS cord-015365-iqdi99pd 1869 11 enrolled enrol VBN cord-015365-iqdi99pd 1869 12 in in IN cord-015365-iqdi99pd 1869 13 this this DT cord-015365-iqdi99pd 1869 14 study study NN cord-015365-iqdi99pd 1869 15 group group NN cord-015365-iqdi99pd 1869 16 evidenced evidence VBD cord-015365-iqdi99pd 1869 17 an an DT cord-015365-iqdi99pd 1869 18 ejection ejection NN cord-015365-iqdi99pd 1869 19 fraction fraction NN cord-015365-iqdi99pd 1869 20 of of IN cord-015365-iqdi99pd 1869 21 52.35 52.35 CD cord-015365-iqdi99pd 1869 22 % % NN cord-015365-iqdi99pd 1869 23 AE AE NNP cord-015365-iqdi99pd 1869 24 1.96 1.96 CD cord-015365-iqdi99pd 1869 25 % % NN cord-015365-iqdi99pd 1869 26 compared compare VBN cord-015365-iqdi99pd 1869 27 to to IN cord-015365-iqdi99pd 1869 28 42.91 42.91 CD cord-015365-iqdi99pd 1869 29 % % NN cord-015365-iqdi99pd 1869 30 AE AE NNP cord-015365-iqdi99pd 1869 31 2.22 2.22 CD cord-015365-iqdi99pd 1869 32 % % NN cord-015365-iqdi99pd 1869 33 in in IN cord-015365-iqdi99pd 1869 34 controls control NNS cord-015365-iqdi99pd 1869 35 ( ( -LRB- cord-015365-iqdi99pd 1869 36 n n NNP cord-015365-iqdi99pd 1869 37 ¼ ¼ NNP cord-015365-iqdi99pd 1869 38 13 13 CD cord-015365-iqdi99pd 1869 39 , , , cord-015365-iqdi99pd 1869 40 p p NN cord-015365-iqdi99pd 1869 41 < < XX cord-015365-iqdi99pd 1869 42 0.001 0.001 CD cord-015365-iqdi99pd 1869 43 ) ) -RRB- cord-015365-iqdi99pd 1869 44 . . . cord-015365-iqdi99pd 1870 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1870 2 . . . cord-015365-iqdi99pd 1871 1 Via via IN cord-015365-iqdi99pd 1871 2 the the DT cord-015365-iqdi99pd 1871 3 mechanism mechanism NN cord-015365-iqdi99pd 1871 4 of of IN cord-015365-iqdi99pd 1871 5 apoptosis apoptosis NN cord-015365-iqdi99pd 1871 6 , , , cord-015365-iqdi99pd 1871 7 ATG ATG NNP cord-015365-iqdi99pd 1871 8 induces induce VBZ cord-015365-iqdi99pd 1871 9 a a DT cord-015365-iqdi99pd 1871 10 plethora plethora NN cord-015365-iqdi99pd 1871 11 of of IN cord-015365-iqdi99pd 1871 12 pro pro JJ cord-015365-iqdi99pd 1871 13 - - JJ cord-015365-iqdi99pd 1871 14 angiogenic angiogenic JJ cord-015365-iqdi99pd 1871 15 and and CC cord-015365-iqdi99pd 1871 16 immune immune JJ cord-015365-iqdi99pd 1871 17 - - HYPH cord-015365-iqdi99pd 1871 18 modulatory modulatory JJ cord-015365-iqdi99pd 1871 19 factors factor NNS cord-015365-iqdi99pd 1871 20 . . . cord-015365-iqdi99pd 1872 1 Secretion secretion NN cord-015365-iqdi99pd 1872 2 of of IN cord-015365-iqdi99pd 1872 3 this this DT cord-015365-iqdi99pd 1872 4 ensemble ensemble NN cord-015365-iqdi99pd 1872 5 of of IN cord-015365-iqdi99pd 1872 6 cytokines cytokine NNS cord-015365-iqdi99pd 1872 7 and and CC cord-015365-iqdi99pd 1872 8 chemokines chemokine NNS cord-015365-iqdi99pd 1872 9 attracts attract VBZ cord-015365-iqdi99pd 1872 10 macrophages macrophage NNS cord-015365-iqdi99pd 1872 11 / / SYM cord-015365-iqdi99pd 1872 12 monocytes monocyte VBZ cord-015365-iqdi99pd 1872 13 into into IN cord-015365-iqdi99pd 1872 14 the the DT cord-015365-iqdi99pd 1872 15 infarcted infarcted JJ cord-015365-iqdi99pd 1872 16 area area NN cord-015365-iqdi99pd 1872 17 , , , cord-015365-iqdi99pd 1872 18 and and CC cord-015365-iqdi99pd 1872 19 attenuates attenuate VBZ cord-015365-iqdi99pd 1872 20 inflammation inflammation NN cord-015365-iqdi99pd 1872 21 after after IN cord-015365-iqdi99pd 1872 22 myocardial myocardial JJ cord-015365-iqdi99pd 1872 23 infarction infarction NN cord-015365-iqdi99pd 1872 24 . . . cord-015365-iqdi99pd 1873 1 In in IN cord-015365-iqdi99pd 1873 2 conclusion conclusion NN cord-015365-iqdi99pd 1873 3 , , , cord-015365-iqdi99pd 1873 4 interaction interaction NN cord-015365-iqdi99pd 1873 5 of of IN cord-015365-iqdi99pd 1873 6 these these DT cord-015365-iqdi99pd 1873 7 factors factor NNS cord-015365-iqdi99pd 1873 8 can can MD cord-015365-iqdi99pd 1873 9 significantly significantly RB cord-015365-iqdi99pd 1873 10 reduce reduce VB cord-015365-iqdi99pd 1873 11 infarction infarction NN cord-015365-iqdi99pd 1873 12 size size NN cord-015365-iqdi99pd 1873 13 and and CC cord-015365-iqdi99pd 1873 14 improve improve VB cord-015365-iqdi99pd 1873 15 left leave VBN cord-015365-iqdi99pd 1873 16 ventricular ventricular JJ cord-015365-iqdi99pd 1873 17 function function NN cord-015365-iqdi99pd 1873 18 after after IN cord-015365-iqdi99pd 1873 19 experimental experimental JJ cord-015365-iqdi99pd 1873 20 myocardial myocardial JJ cord-015365-iqdi99pd 1873 21 infarction infarction NN cord-015365-iqdi99pd 1873 22 in in IN cord-015365-iqdi99pd 1873 23 rats rat NNS cord-015365-iqdi99pd 1873 24 . . . cord-015365-iqdi99pd 1874 1 Secretion secretion NN cord-015365-iqdi99pd 1874 2 of of IN cord-015365-iqdi99pd 1874 3 cytokines cytokine NNS cord-015365-iqdi99pd 1874 4 and and CC cord-015365-iqdi99pd 1874 5 chemokines chemokine NNS cord-015365-iqdi99pd 1874 6 by by IN cord-015365-iqdi99pd 1874 7 peripheral peripheral JJ cord-015365-iqdi99pd 1874 8 blood blood NN cord-015365-iqdi99pd 1874 9 mononuclear mononuclear NN cord-015365-iqdi99pd 1874 10 cells cell NNS cord-015365-iqdi99pd 1874 11 is be VBZ cord-015365-iqdi99pd 1874 12 triggered trigger VBN cord-015365-iqdi99pd 1874 13 by by IN cord-015365-iqdi99pd 1874 14 coagulation coagulation NN cord-015365-iqdi99pd 1874 15 products product NNS cord-015365-iqdi99pd 1874 16 these these DT cord-015365-iqdi99pd 1874 17 mediators mediator NNS cord-015365-iqdi99pd 1874 18 systemic systemic JJ cord-015365-iqdi99pd 1874 19 in in IN cord-015365-iqdi99pd 1874 20 immune immune JJ cord-015365-iqdi99pd 1874 21 activation activation NN cord-015365-iqdi99pd 1874 22 / / SYM cord-015365-iqdi99pd 1874 23 sepsis sepsis NN cord-015365-iqdi99pd 1874 24 , , , cord-015365-iqdi99pd 1874 25 wound wind VBN cord-015365-iqdi99pd 1874 26 healing healing NN cord-015365-iqdi99pd 1874 27 , , , cord-015365-iqdi99pd 1874 28 autoimmune autoimmune NN cord-015365-iqdi99pd 1874 29 - - HYPH cord-015365-iqdi99pd 1874 30 diseases disease NNS cord-015365-iqdi99pd 1874 31 , , , cord-015365-iqdi99pd 1874 32 artherosclerosis artherosclerosis NN cord-015365-iqdi99pd 1874 33 and and CC cord-015365-iqdi99pd 1874 34 myocardial myocardial JJ cord-015365-iqdi99pd 1874 35 infarction infarction NN cord-015365-iqdi99pd 1874 36 . . . cord-015365-iqdi99pd 1875 1 However however RB cord-015365-iqdi99pd 1875 2 , , , cord-015365-iqdi99pd 1875 3 cytokines cytokine NNS cord-015365-iqdi99pd 1875 4 and and CC cord-015365-iqdi99pd 1875 5 chemokines chemokine NNS cord-015365-iqdi99pd 1875 6 are be VBP cord-015365-iqdi99pd 1875 7 usually usually RB cord-015365-iqdi99pd 1875 8 not not RB cord-015365-iqdi99pd 1875 9 considered consider VBN cord-015365-iqdi99pd 1875 10 to to TO cord-015365-iqdi99pd 1875 11 be be VB cord-015365-iqdi99pd 1875 12 very very RB cord-015365-iqdi99pd 1875 13 stable stable JJ cord-015365-iqdi99pd 1875 14 after after IN cord-015365-iqdi99pd 1875 15 blood blood NN cord-015365-iqdi99pd 1875 16 collection collection NN cord-015365-iqdi99pd 1875 17 , , , cord-015365-iqdi99pd 1875 18 which which WDT cord-015365-iqdi99pd 1875 19 might may MD cord-015365-iqdi99pd 1875 20 therefore therefore RB cord-015365-iqdi99pd 1875 21 alter alter VB cord-015365-iqdi99pd 1875 22 test test NN cord-015365-iqdi99pd 1875 23 . . . cord-015365-iqdi99pd 1876 1 Results result NNS cord-015365-iqdi99pd 1876 2 . . . cord-015365-iqdi99pd 1877 1 Thus thus RB cord-015365-iqdi99pd 1877 2 , , , cord-015365-iqdi99pd 1877 3 the the DT cord-015365-iqdi99pd 1877 4 aim aim NN cord-015365-iqdi99pd 1877 5 of of IN cord-015365-iqdi99pd 1877 6 the the DT cord-015365-iqdi99pd 1877 7 pilot pilot NN cord-015365-iqdi99pd 1877 8 study study NN cord-015365-iqdi99pd 1877 9 was be VBD cord-015365-iqdi99pd 1877 10 to to TO cord-015365-iqdi99pd 1877 11 obtain obtain VB cord-015365-iqdi99pd 1877 12 better well JJR cord-015365-iqdi99pd 1877 13 knowledge knowledge NN cord-015365-iqdi99pd 1877 14 about about IN cord-015365-iqdi99pd 1877 15 stability stability NN cord-015365-iqdi99pd 1877 16 of of IN cord-015365-iqdi99pd 1877 17 these these DT cord-015365-iqdi99pd 1877 18 mediators mediator NNS cord-015365-iqdi99pd 1877 19 in in IN cord-015365-iqdi99pd 1877 20 blood blood NN cord-015365-iqdi99pd 1877 21 samples sample NNS cord-015365-iqdi99pd 1877 22 for for IN cord-015365-iqdi99pd 1877 23 interpretation interpretation NN cord-015365-iqdi99pd 1877 24 of of IN cord-015365-iqdi99pd 1877 25 test test NN cord-015365-iqdi99pd 1877 26 results result NNS cord-015365-iqdi99pd 1877 27 . . . cord-015365-iqdi99pd 1878 1 Methods method NNS cord-015365-iqdi99pd 1878 2 . . . cord-015365-iqdi99pd 1879 1 Venous venous JJ cord-015365-iqdi99pd 1879 2 blood blood NN cord-015365-iqdi99pd 1879 3 was be VBD cord-015365-iqdi99pd 1879 4 taken take VBN cord-015365-iqdi99pd 1879 5 from from IN cord-015365-iqdi99pd 1879 6 healthy healthy JJ cord-015365-iqdi99pd 1879 7 probands proband NNS cord-015365-iqdi99pd 1879 8 ( ( -LRB- cord-015365-iqdi99pd 1879 9 n n CC cord-015365-iqdi99pd 1879 10 ¼ ¼ NNP cord-015365-iqdi99pd 1879 11 7 7 CD cord-015365-iqdi99pd 1879 12 ) ) -RRB- cord-015365-iqdi99pd 1879 13 using use VBG cord-015365-iqdi99pd 1879 14 different different JJ cord-015365-iqdi99pd 1879 15 blood blood NN cord-015365-iqdi99pd 1879 16 tubes tube NNS cord-015365-iqdi99pd 1879 17 ( ( -LRB- cord-015365-iqdi99pd 1879 18 serum serum NN cord-015365-iqdi99pd 1879 19 , , , cord-015365-iqdi99pd 1879 20 heparin heparin NN cord-015365-iqdi99pd 1879 21 plasma plasma NN cord-015365-iqdi99pd 1879 22 and and CC cord-015365-iqdi99pd 1879 23 EDTA EDTA NNP cord-015365-iqdi99pd 1879 24 plasma plasma NN cord-015365-iqdi99pd 1879 25 ) ) -RRB- cord-015365-iqdi99pd 1879 26 . . . cord-015365-iqdi99pd 1880 1 Blood blood NN cord-015365-iqdi99pd 1880 2 tubes tube NNS cord-015365-iqdi99pd 1880 3 were be VBD cord-015365-iqdi99pd 1880 4 either either RB cord-015365-iqdi99pd 1880 5 centrifuged centrifuge VBN cord-015365-iqdi99pd 1880 6 initially initially RB cord-015365-iqdi99pd 1880 7 within within IN cord-015365-iqdi99pd 1880 8 20 20 CD cord-015365-iqdi99pd 1880 9 minutes minute NNS cord-015365-iqdi99pd 1880 10 after after IN cord-015365-iqdi99pd 1880 11 venipuncture venipuncture NN cord-015365-iqdi99pd 1880 12 and and CC cord-015365-iqdi99pd 1880 13 kept keep VBD cord-015365-iqdi99pd 1880 14 frozen freeze VBN cord-015365-iqdi99pd 1880 15 at at IN cord-015365-iqdi99pd 1880 16 À80 À80 NNP cord-015365-iqdi99pd 1880 17 until until IN cord-015365-iqdi99pd 1880 18 further further JJ cord-015365-iqdi99pd 1880 19 testing testing NN cord-015365-iqdi99pd 1880 20 or or CC cord-015365-iqdi99pd 1880 21 were be VBD cord-015365-iqdi99pd 1880 22 stored store VBN cord-015365-iqdi99pd 1880 23 at at IN cord-015365-iqdi99pd 1880 24 4 4 CD cord-015365-iqdi99pd 1880 25 C C NNP cord-015365-iqdi99pd 1880 26 , , , cord-015365-iqdi99pd 1880 27 at at IN cord-015365-iqdi99pd 1880 28 room room NN cord-015365-iqdi99pd 1880 29 temperature temperature NN cord-015365-iqdi99pd 1880 30 ( ( -LRB- cord-015365-iqdi99pd 1880 31 RT RT NNP cord-015365-iqdi99pd 1880 32 ) ) -RRB- cord-015365-iqdi99pd 1880 33 or or CC cord-015365-iqdi99pd 1880 34 at at IN cord-015365-iqdi99pd 1880 35 37 37 CD cord-015365-iqdi99pd 1880 36 for for IN cord-015365-iqdi99pd 1880 37 up up IN cord-015365-iqdi99pd 1880 38 to to TO cord-015365-iqdi99pd 1880 39 24 24 CD cord-015365-iqdi99pd 1880 40 hours hour NNS cord-015365-iqdi99pd 1880 41 . . . cord-015365-iqdi99pd 1881 1 Samples sample NNS cord-015365-iqdi99pd 1881 2 were be VBD cord-015365-iqdi99pd 1881 3 evaluated evaluate VBN cord-015365-iqdi99pd 1881 4 for for IN cord-015365-iqdi99pd 1881 5 IL-1ß IL-1ß NNS cord-015365-iqdi99pd 1881 6 , , , cord-015365-iqdi99pd 1881 7 IL-6 IL-6 NNP cord-015365-iqdi99pd 1881 8 , , , cord-015365-iqdi99pd 1881 9 TNF TNF NNP cord-015365-iqdi99pd 1881 10 - - : cord-015365-iqdi99pd 1881 11 and and CC cord-015365-iqdi99pd 1881 12 for for IN cord-015365-iqdi99pd 1881 13 selected select VBN cord-015365-iqdi99pd 1881 14 chemokines chemokine NNS cord-015365-iqdi99pd 1881 15 such such JJ cord-015365-iqdi99pd 1881 16 as as IN cord-015365-iqdi99pd 1881 17 interleukin-8 interleukin-8 NNP cord-015365-iqdi99pd 1881 18 , , , cord-015365-iqdi99pd 1882 1 epithelial epithelial JJ cord-015365-iqdi99pd 1882 2 neutrophil neutrophil NN cord-015365-iqdi99pd 1882 3 - - HYPH cord-015365-iqdi99pd 1882 4 activating activate VBG cord-015365-iqdi99pd 1882 5 protein protein NN cord-015365-iqdi99pd 1882 6 78 78 CD cord-015365-iqdi99pd 1882 7 ( ( -LRB- cord-015365-iqdi99pd 1882 8 ENA-78 ENA-78 NNP cord-015365-iqdi99pd 1882 9 ) ) -RRB- cord-015365-iqdi99pd 1882 10 and and CC cord-015365-iqdi99pd 1882 11 granulocyte granulocyte NN cord-015365-iqdi99pd 1882 12 chemotactic chemotactic JJ cord-015365-iqdi99pd 1882 13 peptide-2 peptide-2 NNP cord-015365-iqdi99pd 1883 1 ( ( -LRB- cord-015365-iqdi99pd 1883 2 GCP-2 gcp-2 RB cord-015365-iqdi99pd 1883 3 ) ) -RRB- cord-015365-iqdi99pd 1883 4 using use VBG cord-015365-iqdi99pd 1883 5 commercially commercially RB cord-015365-iqdi99pd 1883 6 available available JJ cord-015365-iqdi99pd 1883 7 enzyme enzyme NN cord-015365-iqdi99pd 1883 8 - - HYPH cord-015365-iqdi99pd 1883 9 linked link VBN cord-015365-iqdi99pd 1883 10 immunosorbent immunosorbent JJ cord-015365-iqdi99pd 1883 11 assay assay NN cord-015365-iqdi99pd 1883 12 ( ( -LRB- cord-015365-iqdi99pd 1883 13 ELISA ELISA NNP cord-015365-iqdi99pd 1883 14 ) ) -RRB- cord-015365-iqdi99pd 1883 15 kits kit NNS cord-015365-iqdi99pd 1883 16 . . . cord-015365-iqdi99pd 1884 1 Results result NNS cord-015365-iqdi99pd 1884 2 . . . cord-015365-iqdi99pd 1885 1 Interestingly interestingly RB cord-015365-iqdi99pd 1885 2 all all DT cord-015365-iqdi99pd 1885 3 examined examine VBN cord-015365-iqdi99pd 1885 4 mediators mediator NNS cord-015365-iqdi99pd 1885 5 rise rise VB cord-015365-iqdi99pd 1885 6 when when WRB cord-015365-iqdi99pd 1885 7 samples sample NNS cord-015365-iqdi99pd 1885 8 were be VBD cord-015365-iqdi99pd 1885 9 stored store VBN cord-015365-iqdi99pd 1885 10 above above IN cord-015365-iqdi99pd 1885 11 room room NN cord-015365-iqdi99pd 1885 12 temperature temperature NN cord-015365-iqdi99pd 1885 13 for for IN cord-015365-iqdi99pd 1885 14 more more JJR cord-015365-iqdi99pd 1885 15 than than IN cord-015365-iqdi99pd 1885 16 4 4 CD cord-015365-iqdi99pd 1885 17 hours hour NNS cord-015365-iqdi99pd 1885 18 in in IN cord-015365-iqdi99pd 1885 19 serum serum NN cord-015365-iqdi99pd 1885 20 tubes tube NNS cord-015365-iqdi99pd 1885 21 . . . cord-015365-iqdi99pd 1886 1 The the DT cord-015365-iqdi99pd 1886 2 rise rise NN cord-015365-iqdi99pd 1886 3 of of IN cord-015365-iqdi99pd 1886 4 serum serum NN cord-015365-iqdi99pd 1886 5 chemokine chemokine NN cord-015365-iqdi99pd 1886 6 and and CC cord-015365-iqdi99pd 1886 7 cytokine cytokine NN cord-015365-iqdi99pd 1886 8 levels level NNS cord-015365-iqdi99pd 1886 9 culminated culminate VBD cord-015365-iqdi99pd 1886 10 in in IN cord-015365-iqdi99pd 1886 11 a a DT cord-015365-iqdi99pd 1886 12 79-fold 79-fold CD cord-015365-iqdi99pd 1886 13 increase increase NN cord-015365-iqdi99pd 1886 14 for for IN cord-015365-iqdi99pd 1886 15 IL-6 IL-6 NNP cord-015365-iqdi99pd 1886 16 ( ( -LRB- cord-015365-iqdi99pd 1886 17 p p NN cord-015365-iqdi99pd 1886 18 < < XX cord-015365-iqdi99pd 1886 19 0.0081 0.0081 CD cord-015365-iqdi99pd 1886 20 ) ) -RRB- cord-015365-iqdi99pd 1886 21 , , , cord-015365-iqdi99pd 1886 22 a a DT cord-015365-iqdi99pd 1886 23 22-fold 22-fold CD cord-015365-iqdi99pd 1886 24 increase increase NN cord-015365-iqdi99pd 1886 25 for for IN cord-015365-iqdi99pd 1886 26 ENA-78 ENA-78 NNP cord-015365-iqdi99pd 1887 1 ( ( -LRB- cord-015365-iqdi99pd 1887 2 p p NN cord-015365-iqdi99pd 1887 3 < < XX cord-015365-iqdi99pd 1887 4 0.0006 0.0006 CD cord-015365-iqdi99pd 1887 5 ) ) -RRB- cord-015365-iqdi99pd 1887 6 and and CC cord-015365-iqdi99pd 1887 7 a a DT cord-015365-iqdi99pd 1887 8 17-fold 17-fold JJ cord-015365-iqdi99pd 1887 9 increase increase NN cord-015365-iqdi99pd 1887 10 for for IN cord-015365-iqdi99pd 1887 11 GCP-2 gcp-2 JJ cord-015365-iqdi99pd 1887 12 ( ( -LRB- cord-015365-iqdi99pd 1887 13 p p NN cord-015365-iqdi99pd 1887 14 < < XX cord-015365-iqdi99pd 1887 15 0.0026 0.0026 CD cord-015365-iqdi99pd 1887 16 ) ) -RRB- cord-015365-iqdi99pd 1887 17 compared compare VBN cord-015365-iqdi99pd 1887 18 to to IN cord-015365-iqdi99pd 1887 19 basic basic JJ cord-015365-iqdi99pd 1887 20 values value NNS cord-015365-iqdi99pd 1887 21 . . . cord-015365-iqdi99pd 1888 1 Serum serum NN cord-015365-iqdi99pd 1888 2 levels level NNS cord-015365-iqdi99pd 1888 3 of of IN cord-015365-iqdi99pd 1889 1 IL-1 IL-1 NNP cord-015365-iqdi99pd 1889 2 and and CC cord-015365-iqdi99pd 1889 3 TNF TNF NNP cord-015365-iqdi99pd 1889 4 - - : cord-015365-iqdi99pd 1889 5 where where WRB cord-015365-iqdi99pd 1889 6 not not RB cord-015365-iqdi99pd 1889 7 detectable detectable JJ cord-015365-iqdi99pd 1889 8 at at IN cord-015365-iqdi99pd 1889 9 basic basic JJ cord-015365-iqdi99pd 1889 10 samples sample NNS cord-015365-iqdi99pd 1889 11 but but CC cord-015365-iqdi99pd 1889 12 rise rise VBP cord-015365-iqdi99pd 1889 13 up up IN cord-015365-iqdi99pd 1889 14 to to IN cord-015365-iqdi99pd 1889 15 1157 1157 CD cord-015365-iqdi99pd 1889 16 pg pg NN cord-015365-iqdi99pd 1889 17 / / SYM cord-015365-iqdi99pd 1889 18 ml ml NN cord-015365-iqdi99pd 1889 19 ( ( -LRB- cord-015365-iqdi99pd 1889 20 mean mean VB cord-015365-iqdi99pd 1889 21 IL-1 IL-1 NNP cord-015365-iqdi99pd 1889 22 , , , cord-015365-iqdi99pd 1889 23 p p NN cord-015365-iqdi99pd 1889 24 < < XX cord-015365-iqdi99pd 1889 25 0.03 0.03 CD cord-015365-iqdi99pd 1889 26 ) ) -RRB- cord-015365-iqdi99pd 1889 27 and and CC cord-015365-iqdi99pd 1889 28 488 488 CD cord-015365-iqdi99pd 1889 29 pg pg NN cord-015365-iqdi99pd 1889 30 / / SYM cord-015365-iqdi99pd 1889 31 ml ml NN cord-015365-iqdi99pd 1890 1 ( ( -LRB- cord-015365-iqdi99pd 1890 2 mean mean VB cord-015365-iqdi99pd 1891 1 TNF- TNF- NNP cord-015365-iqdi99pd 1891 2 , , , cord-015365-iqdi99pd 1891 3 p p NN cord-015365-iqdi99pd 1891 4 < < XX cord-015365-iqdi99pd 1891 5 0.03 0.03 CD cord-015365-iqdi99pd 1891 6 ) ) -RRB- cord-015365-iqdi99pd 1891 7 . . . cord-015365-iqdi99pd 1892 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1892 2 . . . cord-015365-iqdi99pd 1893 1 These these DT cord-015365-iqdi99pd 1893 2 data datum NNS cord-015365-iqdi99pd 1893 3 indicate indicate VBP cord-015365-iqdi99pd 1893 4 that that IN cord-015365-iqdi99pd 1893 5 the the DT cord-015365-iqdi99pd 1893 6 most most RBS cord-015365-iqdi99pd 1893 7 chemokine chemokine NN cord-015365-iqdi99pd 1893 8 and and CC cord-015365-iqdi99pd 1893 9 cytokine cytokine NN cord-015365-iqdi99pd 1893 10 levels level NNS cord-015365-iqdi99pd 1893 11 remain remain VBP cord-015365-iqdi99pd 1893 12 stable stable JJ cord-015365-iqdi99pd 1893 13 when when WRB cord-015365-iqdi99pd 1893 14 analysed analyse VBN cord-015365-iqdi99pd 1893 15 within within IN cord-015365-iqdi99pd 1893 16 a a DT cord-015365-iqdi99pd 1893 17 short short JJ cord-015365-iqdi99pd 1893 18 interval interval NN cord-015365-iqdi99pd 1893 19 after after IN cord-015365-iqdi99pd 1893 20 venipuncture venipuncture NN cord-015365-iqdi99pd 1893 21 . . . cord-015365-iqdi99pd 1894 1 When when WRB cord-015365-iqdi99pd 1894 2 tubes tube NNS cord-015365-iqdi99pd 1894 3 were be VBD cord-015365-iqdi99pd 1894 4 exposed expose VBN cord-015365-iqdi99pd 1894 5 to to IN cord-015365-iqdi99pd 1894 6 temperatures temperature NNS cord-015365-iqdi99pd 1894 7 higher high JJR cord-015365-iqdi99pd 1894 8 than than IN cord-015365-iqdi99pd 1894 9 24 24 CD cord-015365-iqdi99pd 1894 10 ( ( -LRB- cord-015365-iqdi99pd 1894 11 RT RT NNP cord-015365-iqdi99pd 1894 12 ) ) -RRB- cord-015365-iqdi99pd 1894 13 , , , cord-015365-iqdi99pd 1894 14 levels level NNS cord-015365-iqdi99pd 1894 15 of of IN cord-015365-iqdi99pd 1894 16 measured measured JJ cord-015365-iqdi99pd 1894 17 chemokines chemokine NNS cord-015365-iqdi99pd 1894 18 increased increase VBD cord-015365-iqdi99pd 1894 19 dramatically dramatically RB cord-015365-iqdi99pd 1894 20 . . . cord-015365-iqdi99pd 1894 21 _SP cord-015365-iqdi99pd 1895 1 Background background NN cord-015365-iqdi99pd 1895 2 . . . cord-015365-iqdi99pd 1896 1 Rabbit Rabbit NNP cord-015365-iqdi99pd 1896 2 antithymocyte antithymocyte NN cord-015365-iqdi99pd 1896 3 globulin globulin NN cord-015365-iqdi99pd 1896 4 ( ( -LRB- cord-015365-iqdi99pd 1896 5 rATG rATG NNP cord-015365-iqdi99pd 1896 6 ) ) -RRB- cord-015365-iqdi99pd 1896 7 is be VBZ cord-015365-iqdi99pd 1896 8 widely widely RB cord-015365-iqdi99pd 1896 9 used use VBN cord-015365-iqdi99pd 1896 10 as as IN cord-015365-iqdi99pd 1896 11 induction induction NN cord-015365-iqdi99pd 1896 12 agent agent NN cord-015365-iqdi99pd 1896 13 in in IN cord-015365-iqdi99pd 1896 14 solid solid JJ cord-015365-iqdi99pd 1896 15 organ organ NN cord-015365-iqdi99pd 1896 16 transplantation transplantation NN cord-015365-iqdi99pd 1896 17 . . . cord-015365-iqdi99pd 1897 1 Beside beside IN cord-015365-iqdi99pd 1897 2 depletion depletion NN cord-015365-iqdi99pd 1897 3 of of IN cord-015365-iqdi99pd 1897 4 circulating circulate VBG cord-015365-iqdi99pd 1897 5 lymphocytes lymphocyte NNS cord-015365-iqdi99pd 1897 6 there there EX cord-015365-iqdi99pd 1897 7 is be VBZ cord-015365-iqdi99pd 1897 8 a a DT cord-015365-iqdi99pd 1897 9 growing grow VBG cord-015365-iqdi99pd 1897 10 body body NN cord-015365-iqdi99pd 1897 11 of of IN cord-015365-iqdi99pd 1897 12 evidence evidence NN cord-015365-iqdi99pd 1897 13 suggesting suggest VBG cord-015365-iqdi99pd 1897 14 that that IN cord-015365-iqdi99pd 1897 15 rATG rATG NNP cord-015365-iqdi99pd 1897 16 may may MD cord-015365-iqdi99pd 1897 17 also also RB cord-015365-iqdi99pd 1897 18 play play VB cord-015365-iqdi99pd 1897 19 a a DT cord-015365-iqdi99pd 1897 20 pivotal pivotal JJ cord-015365-iqdi99pd 1897 21 role role NN cord-015365-iqdi99pd 1897 22 in in IN cord-015365-iqdi99pd 1897 23 modulating modulate VBG cord-015365-iqdi99pd 1897 24 the the DT cord-015365-iqdi99pd 1897 25 immune immune JJ cord-015365-iqdi99pd 1897 26 system system NN cord-015365-iqdi99pd 1897 27 . . . cord-015365-iqdi99pd 1898 1 As as IN cord-015365-iqdi99pd 1898 2 blood blood NN cord-015365-iqdi99pd 1898 3 circulating circulate VBG cord-015365-iqdi99pd 1898 4 endothelial endothelial JJ cord-015365-iqdi99pd 1898 5 cells cell NNS cord-015365-iqdi99pd 1898 6 ( ( -LRB- cord-015365-iqdi99pd 1898 7 CECs cec NNS cord-015365-iqdi99pd 1898 8 ) ) -RRB- cord-015365-iqdi99pd 1898 9 and and CC cord-015365-iqdi99pd 1898 10 circulating circulate VBG cord-015365-iqdi99pd 1898 11 hematopoietic hematopoietic JJ cord-015365-iqdi99pd 1898 12 progenitor progenitor NN cord-015365-iqdi99pd 1898 13 cells cell NNS cord-015365-iqdi99pd 1898 14 ( ( -LRB- cord-015365-iqdi99pd 1898 15 CPCs CPCs NNP cord-015365-iqdi99pd 1898 16 ) ) -RRB- cord-015365-iqdi99pd 1898 17 represent represent VBP cord-015365-iqdi99pd 1898 18 two two CD cord-015365-iqdi99pd 1898 19 minute minute NN cord-015365-iqdi99pd 1898 20 fractions fraction NNS cord-015365-iqdi99pd 1898 21 ( ( -LRB- cord-015365-iqdi99pd 1898 22 CECs cec NNS cord-015365-iqdi99pd 1898 23 : : : cord-015365-iqdi99pd 1898 24 0.1 0.1 CD cord-015365-iqdi99pd 1898 25 % % NN cord-015365-iqdi99pd 1898 26 to to TO cord-015365-iqdi99pd 1898 27 6.0 6.0 CD cord-015365-iqdi99pd 1898 28 % % NN cord-015365-iqdi99pd 1898 29 and and CC cord-015365-iqdi99pd 1898 30 CPCs cpc NNS cord-015365-iqdi99pd 1898 31 : : : cord-015365-iqdi99pd 1898 32 0.01 0.01 CD cord-015365-iqdi99pd 1898 33 - - HYPH cord-015365-iqdi99pd 1898 34 0.20 0.20 CD cord-015365-iqdi99pd 1898 35 % % NN cord-015365-iqdi99pd 1898 36 ) ) -RRB- cord-015365-iqdi99pd 1898 37 of of IN cord-015365-iqdi99pd 1898 38 blood blood NN cord-015365-iqdi99pd 1898 39 mononuclear mononuclear NN cord-015365-iqdi99pd 1898 40 cells cell NNS cord-015365-iqdi99pd 1898 41 that that WDT cord-015365-iqdi99pd 1898 42 are be VBP cord-015365-iqdi99pd 1898 43 thought think VBN cord-015365-iqdi99pd 1898 44 to to TO cord-015365-iqdi99pd 1898 45 play play VB cord-015365-iqdi99pd 1898 46 important important JJ cord-015365-iqdi99pd 1898 47 roles role NNS cord-015365-iqdi99pd 1898 48 in in IN cord-015365-iqdi99pd 1898 49 tissue tissue NN cord-015365-iqdi99pd 1898 50 vascularisation vascularisation NN cord-015365-iqdi99pd 1898 51 , , , cord-015365-iqdi99pd 1898 52 the the DT cord-015365-iqdi99pd 1898 53 study study NN cord-015365-iqdi99pd 1898 54 of of IN cord-015365-iqdi99pd 1898 55 both both DT cord-015365-iqdi99pd 1898 56 cell cell NN cord-015365-iqdi99pd 1898 57 types type NNS cord-015365-iqdi99pd 1898 58 is be VBZ cord-015365-iqdi99pd 1898 59 currently currently RB cord-015365-iqdi99pd 1898 60 suggested suggest VBN cord-015365-iqdi99pd 1898 61 as as IN cord-015365-iqdi99pd 1898 62 surrogate surrogate JJ cord-015365-iqdi99pd 1898 63 markers marker NNS cord-015365-iqdi99pd 1898 64 for for IN cord-015365-iqdi99pd 1898 65 numerous numerous JJ cord-015365-iqdi99pd 1898 66 pathologies pathology NNS cord-015365-iqdi99pd 1898 67 . . . cord-015365-iqdi99pd 1899 1 Especially especially RB cord-015365-iqdi99pd 1899 2 the the DT cord-015365-iqdi99pd 1899 3 noninvasive noninvasive JJ cord-015365-iqdi99pd 1899 4 endothelial endothelial JJ cord-015365-iqdi99pd 1899 5 evaluation evaluation NN cord-015365-iqdi99pd 1899 6 as as IN cord-015365-iqdi99pd 1899 7 an an DT cord-015365-iqdi99pd 1899 8 early early JJ cord-015365-iqdi99pd 1899 9 index index NN cord-015365-iqdi99pd 1899 10 of of IN cord-015365-iqdi99pd 1899 11 vascular vascular JJ cord-015365-iqdi99pd 1899 12 injury injury NN cord-015365-iqdi99pd 1899 13 following follow VBG cord-015365-iqdi99pd 1899 14 kidney kidney NN cord-015365-iqdi99pd 1899 15 transplantation transplantation NN cord-015365-iqdi99pd 1899 16 has have VBZ cord-015365-iqdi99pd 1899 17 been be VBN cord-015365-iqdi99pd 1899 18 already already RB cord-015365-iqdi99pd 1899 19 demonstrated demonstrate VBN cord-015365-iqdi99pd 1899 20 . . . cord-015365-iqdi99pd 1900 1 Methods method NNS cord-015365-iqdi99pd 1900 2 . . . cord-015365-iqdi99pd 1901 1 We -PRON- PRP cord-015365-iqdi99pd 1901 2 used use VBD cord-015365-iqdi99pd 1901 3 four four CD cord-015365-iqdi99pd 1901 4 surface surface NN cord-015365-iqdi99pd 1901 5 markers marker NNS cord-015365-iqdi99pd 1901 6 to to TO cord-015365-iqdi99pd 1901 7 identify identify VB cord-015365-iqdi99pd 1901 8 viable viable JJ cord-015365-iqdi99pd 1901 9 CECs cec NNS cord-015365-iqdi99pd 1901 10 as as IN cord-015365-iqdi99pd 1901 11 CD31bright CD31bright NNP cord-015365-iqdi99pd 1901 12 , , , cord-015365-iqdi99pd 1901 13 CD34dim CD34dim NNP cord-015365-iqdi99pd 1901 14 , , , cord-015365-iqdi99pd 1901 15 CD45- CD45- NNP cord-015365-iqdi99pd 1901 16 , , , cord-015365-iqdi99pd 1901 17 CD133-and cd133-and VB cord-015365-iqdi99pd 1901 18 viable viable JJ cord-015365-iqdi99pd 1901 19 CPCs cpc NNS cord-015365-iqdi99pd 1901 20 as as IN cord-015365-iqdi99pd 1901 21 CD34bright CD34bright NNP cord-015365-iqdi99pd 1901 22 , , , cord-015365-iqdi99pd 1901 23 CD133þ CD133þ NNP cord-015365-iqdi99pd 1901 24 , , , cord-015365-iqdi99pd 1901 25 CD45dim CD45dim NNP cord-015365-iqdi99pd 1901 26 , , , cord-015365-iqdi99pd 1901 27 CD31 CD31 NNP cord-015365-iqdi99pd 1901 28 þ þ CD cord-015365-iqdi99pd 1901 29 cells cell NNS cord-015365-iqdi99pd 1901 30 in in IN cord-015365-iqdi99pd 1901 31 the the DT cord-015365-iqdi99pd 1901 32 peripheral peripheral JJ cord-015365-iqdi99pd 1901 33 blood blood NN cord-015365-iqdi99pd 1901 34 of of IN cord-015365-iqdi99pd 1901 35 liver liver NN cord-015365-iqdi99pd 1901 36 transplanted transplant VBN cord-015365-iqdi99pd 1901 37 recipients recipient NNS cord-015365-iqdi99pd 1901 38 ( ( -LRB- cord-015365-iqdi99pd 1901 39 n n CC cord-015365-iqdi99pd 1901 40 ¼ ¼ NNP cord-015365-iqdi99pd 1901 41 28 28 CD cord-015365-iqdi99pd 1901 42 ) ) -RRB- cord-015365-iqdi99pd 1901 43 until until IN cord-015365-iqdi99pd 1901 44 day day NN cord-015365-iqdi99pd 1901 45 20 20 CD cord-015365-iqdi99pd 1901 46 post post NN cord-015365-iqdi99pd 1901 47 transplantation transplantation NN cord-015365-iqdi99pd 1901 48 via via IN cord-015365-iqdi99pd 1901 49 FACS FACS NNP cord-015365-iqdi99pd 1901 50 - - HYPH cord-015365-iqdi99pd 1901 51 analysis analysis NN cord-015365-iqdi99pd 1901 52 . . . cord-015365-iqdi99pd 1902 1 Results result NNS cord-015365-iqdi99pd 1902 2 . . . cord-015365-iqdi99pd 1903 1 An an DT cord-015365-iqdi99pd 1903 2 induction induction NN cord-015365-iqdi99pd 1903 3 of of IN cord-015365-iqdi99pd 1903 4 CECs cec NNS cord-015365-iqdi99pd 1903 5 was be VBD cord-015365-iqdi99pd 1903 6 exclusively exclusively RB cord-015365-iqdi99pd 1903 7 observed observe VBN cord-015365-iqdi99pd 1903 8 for for IN cord-015365-iqdi99pd 1903 9 rATG rATG VBN cord-015365-iqdi99pd 1903 10 - - HYPH cord-015365-iqdi99pd 1903 11 treated treat VBN cord-015365-iqdi99pd 1903 12 patients patient NNS cord-015365-iqdi99pd 1903 13 ( ( -LRB- cord-015365-iqdi99pd 1903 14 n n CC cord-015365-iqdi99pd 1903 15 ¼ ¼ NNP cord-015365-iqdi99pd 1903 16 17 17 CD cord-015365-iqdi99pd 1903 17 ) ) -RRB- cord-015365-iqdi99pd 1903 18 increasing increase VBG cord-015365-iqdi99pd 1903 19 from from IN cord-015365-iqdi99pd 1903 20 0.56 0.56 CD cord-015365-iqdi99pd 1903 21 % % NN cord-015365-iqdi99pd 1903 22 AE AE NNP cord-015365-iqdi99pd 1903 23 0.98 0.98 CD cord-015365-iqdi99pd 1903 24 % % NN cord-015365-iqdi99pd 1903 25 pre pre JJ cord-015365-iqdi99pd 1903 26 transplantation transplantation NN cord-015365-iqdi99pd 1903 27 to to IN cord-015365-iqdi99pd 1903 28 1.83 1.83 CD cord-015365-iqdi99pd 1903 29 % % NN cord-015365-iqdi99pd 1903 30 AE AE NNP cord-015365-iqdi99pd 1903 31 1.85 1.85 CD cord-015365-iqdi99pd 1903 32 % % NN cord-015365-iqdi99pd 1903 33 at at IN cord-015365-iqdi99pd 1903 34 day day NN cord-015365-iqdi99pd 1903 35 1 1 CD cord-015365-iqdi99pd 1903 36 - - SYM cord-015365-iqdi99pd 1903 37 2 2 CD cord-015365-iqdi99pd 1903 38 post post NN cord-015365-iqdi99pd 1903 39 transplantation transplantation NN cord-015365-iqdi99pd 1903 40 compared compare VBN cord-015365-iqdi99pd 1903 41 with with IN cord-015365-iqdi99pd 1903 42 control control NN cord-015365-iqdi99pd 1903 43 patients patient NNS cord-015365-iqdi99pd 1903 44 receiving receive VBG cord-015365-iqdi99pd 1903 45 standard standard JJ cord-015365-iqdi99pd 1903 46 immunosuppression immunosuppression NN cord-015365-iqdi99pd 1903 47 ( ( -LRB- cord-015365-iqdi99pd 1903 48 n n NN cord-015365-iqdi99pd 1903 49 ¼ ¼ NNP cord-015365-iqdi99pd 1903 50 11 11 CD cord-015365-iqdi99pd 1903 51 ) ) -RRB- cord-015365-iqdi99pd 1903 52 ( ( -LRB- cord-015365-iqdi99pd 1903 53 p p NN cord-015365-iqdi99pd 1903 54 < < XX cord-015365-iqdi99pd 1903 55 0.04 0.04 CD cord-015365-iqdi99pd 1903 56 ) ) -RRB- cord-015365-iqdi99pd 1903 57 . . . cord-015365-iqdi99pd 1904 1 In in IN cord-015365-iqdi99pd 1904 2 addition addition NN cord-015365-iqdi99pd 1904 3 , , , cord-015365-iqdi99pd 1904 4 the the DT cord-015365-iqdi99pd 1904 5 induction induction NN cord-015365-iqdi99pd 1904 6 of of IN cord-015365-iqdi99pd 1904 7 CPCs CPCs NNP cord-015365-iqdi99pd 1904 8 was be VBD cord-015365-iqdi99pd 1904 9 even even RB cord-015365-iqdi99pd 1904 10 more more RBR cord-015365-iqdi99pd 1904 11 pronounced pronounced JJ cord-015365-iqdi99pd 1904 12 illustrating illustrate VBG cord-015365-iqdi99pd 1904 13 an an DT cord-015365-iqdi99pd 1904 14 increase increase NN cord-015365-iqdi99pd 1904 15 in in IN cord-015365-iqdi99pd 1904 16 rATG ratg JJ cord-015365-iqdi99pd 1904 17 treated treat VBN cord-015365-iqdi99pd 1904 18 patients patient NNS cord-015365-iqdi99pd 1904 19 from from IN cord-015365-iqdi99pd 1904 20 0.20 0.20 CD cord-015365-iqdi99pd 1904 21 % % NN cord-015365-iqdi99pd 1904 22 AE AE NNP cord-015365-iqdi99pd 1904 23 0.26 0.26 CD cord-015365-iqdi99pd 1904 24 % % NN cord-015365-iqdi99pd 1904 25 pre pre JJ cord-015365-iqdi99pd 1904 26 transplantation transplantation NN cord-015365-iqdi99pd 1904 27 to to IN cord-015365-iqdi99pd 1904 28 1.55 1.55 CD cord-015365-iqdi99pd 1904 29 % % NN cord-015365-iqdi99pd 1904 30 AE AE NNP cord-015365-iqdi99pd 1904 31 1.75 1.75 CD cord-015365-iqdi99pd 1904 32 % % NN cord-015365-iqdi99pd 1904 33 at at IN cord-015365-iqdi99pd 1904 34 day day NN cord-015365-iqdi99pd 1904 35 1 1 CD cord-015365-iqdi99pd 1904 36 - - SYM cord-015365-iqdi99pd 1904 37 2 2 CD cord-015365-iqdi99pd 1904 38 post post NN cord-015365-iqdi99pd 1904 39 transplantation transplantation NN cord-015365-iqdi99pd 1904 40 ( ( -LRB- cord-015365-iqdi99pd 1904 41 p p NN cord-015365-iqdi99pd 1904 42 < < XX cord-015365-iqdi99pd 1904 43 0.001 0.001 CD cord-015365-iqdi99pd 1904 44 ) ) -RRB- cord-015365-iqdi99pd 1904 45 . . . cord-015365-iqdi99pd 1905 1 A a DT cord-015365-iqdi99pd 1905 2 significant significant JJ cord-015365-iqdi99pd 1905 3 elevation elevation NN cord-015365-iqdi99pd 1905 4 of of IN cord-015365-iqdi99pd 1905 5 blood blood NN cord-015365-iqdi99pd 1905 6 CPCs cpc NNS cord-015365-iqdi99pd 1905 7 is be VBZ cord-015365-iqdi99pd 1905 8 still still RB cord-015365-iqdi99pd 1905 9 detectable detectable JJ cord-015365-iqdi99pd 1905 10 at at IN cord-015365-iqdi99pd 1905 11 day day NN cord-015365-iqdi99pd 1905 12 5 5 CD cord-015365-iqdi99pd 1905 13 ( ( -LRB- cord-015365-iqdi99pd 1905 14 p p NN cord-015365-iqdi99pd 1905 15 ¼ ¼ CD cord-015365-iqdi99pd 1905 16 0.0379 0.0379 CD cord-015365-iqdi99pd 1905 17 compared compare VBN cord-015365-iqdi99pd 1905 18 with with IN cord-015365-iqdi99pd 1905 19 controls control NNS cord-015365-iqdi99pd 1905 20 ) ) -RRB- cord-015365-iqdi99pd 1905 21 and and CC cord-015365-iqdi99pd 1905 22 starts start VBZ cord-015365-iqdi99pd 1905 23 to to TO cord-015365-iqdi99pd 1905 24 decline decline VB cord-015365-iqdi99pd 1905 25 at at IN cord-015365-iqdi99pd 1905 26 day day NN cord-015365-iqdi99pd 1905 27 10 10 CD cord-015365-iqdi99pd 1905 28 post post NN cord-015365-iqdi99pd 1905 29 transplantation transplantation NN cord-015365-iqdi99pd 1905 30 . . . cord-015365-iqdi99pd 1906 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1906 2 . . . cord-015365-iqdi99pd 1907 1 In in IN cord-015365-iqdi99pd 1907 2 summary summary NN cord-015365-iqdi99pd 1907 3 we -PRON- PRP cord-015365-iqdi99pd 1907 4 illustrated illustrate VBD cord-015365-iqdi99pd 1907 5 that that IN cord-015365-iqdi99pd 1907 6 both both DT cord-015365-iqdi99pd 1907 7 CECs cec NNS cord-015365-iqdi99pd 1907 8 and and CC cord-015365-iqdi99pd 1907 9 CPCs CPCs NNPS cord-015365-iqdi99pd 1907 10 were be VBD cord-015365-iqdi99pd 1907 11 detectable detectable JJ cord-015365-iqdi99pd 1907 12 in in IN cord-015365-iqdi99pd 1907 13 numbers number NNS cord-015365-iqdi99pd 1907 14 that that WDT cord-015365-iqdi99pd 1907 15 allows allow VBZ cord-015365-iqdi99pd 1907 16 kinetic kinetic JJ cord-015365-iqdi99pd 1907 17 monitoring monitoring NN cord-015365-iqdi99pd 1907 18 of of IN cord-015365-iqdi99pd 1907 19 these these DT cord-015365-iqdi99pd 1907 20 cell cell NN cord-015365-iqdi99pd 1907 21 types type NNS cord-015365-iqdi99pd 1907 22 post post VBP cord-015365-iqdi99pd 1907 23 transplantation transplantation NN cord-015365-iqdi99pd 1907 24 and and CC cord-015365-iqdi99pd 1907 25 that that IN cord-015365-iqdi99pd 1907 26 rATG ratg JJ cord-015365-iqdi99pd 1907 27 treatment treatment NN cord-015365-iqdi99pd 1907 28 results result NNS cord-015365-iqdi99pd 1907 29 in in IN cord-015365-iqdi99pd 1907 30 a a DT cord-015365-iqdi99pd 1907 31 transient transient JJ cord-015365-iqdi99pd 1907 32 induction induction NN cord-015365-iqdi99pd 1907 33 . . . cord-015365-iqdi99pd 1908 1 As as IN cord-015365-iqdi99pd 1908 2 clinical clinical JJ cord-015365-iqdi99pd 1908 3 correlations correlation NNS cord-015365-iqdi99pd 1908 4 between between IN cord-015365-iqdi99pd 1908 5 the the DT cord-015365-iqdi99pd 1908 6 concentration concentration NN cord-015365-iqdi99pd 1908 7 of of IN cord-015365-iqdi99pd 1908 8 these these DT cord-015365-iqdi99pd 1908 9 two two CD cord-015365-iqdi99pd 1908 10 populations population NNS cord-015365-iqdi99pd 1908 11 and and CC cord-015365-iqdi99pd 1908 12 the the DT cord-015365-iqdi99pd 1908 13 effect effect NN cord-015365-iqdi99pd 1908 14 of of IN cord-015365-iqdi99pd 1908 15 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1908 16 regimens regimen NNS cord-015365-iqdi99pd 1908 17 has have VBZ cord-015365-iqdi99pd 1908 18 been be VBN cord-015365-iqdi99pd 1908 19 already already RB cord-015365-iqdi99pd 1908 20 proven prove VBN cord-015365-iqdi99pd 1908 21 , , , cord-015365-iqdi99pd 1908 22 validation validation NN cord-015365-iqdi99pd 1908 23 of of IN cord-015365-iqdi99pd 1908 24 these these DT cord-015365-iqdi99pd 1908 25 cell cell NN cord-015365-iqdi99pd 1908 26 populations population NNS cord-015365-iqdi99pd 1908 27 as as IN cord-015365-iqdi99pd 1908 28 biomarkers biomarker NNS cord-015365-iqdi99pd 1908 29 in in IN cord-015365-iqdi99pd 1908 30 the the DT cord-015365-iqdi99pd 1908 31 setting setting NN cord-015365-iqdi99pd 1908 32 of of IN cord-015365-iqdi99pd 1908 33 solid solid JJ cord-015365-iqdi99pd 1908 34 organ organ NN cord-015365-iqdi99pd 1908 35 transplantation transplantation NN cord-015365-iqdi99pd 1908 36 remains remain VBZ cord-015365-iqdi99pd 1908 37 to to TO cord-015365-iqdi99pd 1908 38 be be VB cord-015365-iqdi99pd 1908 39 determined determine VBN cord-015365-iqdi99pd 1908 40 . . . cord-015365-iqdi99pd 1909 1 Background background NN cord-015365-iqdi99pd 1909 2 . . . cord-015365-iqdi99pd 1910 1 Lipocalin-2 Lipocalin-2 NNP cord-015365-iqdi99pd 1911 1 ( ( -LRB- cord-015365-iqdi99pd 1911 2 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1911 3 ) ) -RRB- cord-015365-iqdi99pd 1911 4 has have VBZ cord-015365-iqdi99pd 1911 5 been be VBN cord-015365-iqdi99pd 1911 6 described describe VBN cord-015365-iqdi99pd 1911 7 as as IN cord-015365-iqdi99pd 1911 8 a a DT cord-015365-iqdi99pd 1911 9 marker marker NN cord-015365-iqdi99pd 1911 10 and and CC cord-015365-iqdi99pd 1911 11 potential potential JJ cord-015365-iqdi99pd 1911 12 positive positive JJ cord-015365-iqdi99pd 1911 13 modulator modulator NN cord-015365-iqdi99pd 1911 14 of of IN cord-015365-iqdi99pd 1911 15 inflammation inflammation NN cord-015365-iqdi99pd 1911 16 during during IN cord-015365-iqdi99pd 1911 17 ischemia ischemia NN cord-015365-iqdi99pd 1911 18 / / SYM cord-015365-iqdi99pd 1911 19 reperfusion reperfusion NN cord-015365-iqdi99pd 1911 20 injury injury NN cord-015365-iqdi99pd 1911 21 ( ( -LRB- cord-015365-iqdi99pd 1911 22 IRI IRI NNP cord-015365-iqdi99pd 1911 23 ) ) -RRB- cord-015365-iqdi99pd 1911 24 following follow VBG cord-015365-iqdi99pd 1911 25 solid solid JJ cord-015365-iqdi99pd 1911 26 organ organ NN cord-015365-iqdi99pd 1911 27 transplantation transplantation NN cord-015365-iqdi99pd 1911 28 . . . cord-015365-iqdi99pd 1912 1 Data datum NNS cord-015365-iqdi99pd 1912 2 on on IN cord-015365-iqdi99pd 1912 3 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1912 4 expression expression NN cord-015365-iqdi99pd 1912 5 during during IN cord-015365-iqdi99pd 1912 6 allograft allograft NN cord-015365-iqdi99pd 1912 7 rejection rejection NN cord-015365-iqdi99pd 1912 8 have have VBP cord-015365-iqdi99pd 1912 9 been be VBN cord-015365-iqdi99pd 1912 10 missing miss VBG cord-015365-iqdi99pd 1912 11 so so RB cord-015365-iqdi99pd 1912 12 far far RB cord-015365-iqdi99pd 1912 13 . . . cord-015365-iqdi99pd 1913 1 Methods method NNS cord-015365-iqdi99pd 1913 2 . . . cord-015365-iqdi99pd 1914 1 Sera Sera NNP cord-015365-iqdi99pd 1914 2 of of IN cord-015365-iqdi99pd 1914 3 68 68 CD cord-015365-iqdi99pd 1914 4 patients patient NNS cord-015365-iqdi99pd 1914 5 undergoing undergo VBG cord-015365-iqdi99pd 1914 6 orthotopic orthotopic JJ cord-015365-iqdi99pd 1914 7 liver liver NN cord-015365-iqdi99pd 1914 8 transplantation transplantation NN cord-015365-iqdi99pd 1914 9 were be VBD cord-015365-iqdi99pd 1914 10 collected collect VBN cord-015365-iqdi99pd 1914 11 preoperatively preoperatively RB cord-015365-iqdi99pd 1914 12 and and CC cord-015365-iqdi99pd 1914 13 postoperatively postoperatively RB cord-015365-iqdi99pd 1914 14 from from IN cord-015365-iqdi99pd 1914 15 day day NN cord-015365-iqdi99pd 1914 16 1 1 CD cord-015365-iqdi99pd 1914 17 to to IN cord-015365-iqdi99pd 1914 18 15 15 CD cord-015365-iqdi99pd 1914 19 . . . cord-015365-iqdi99pd 1915 1 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1915 2 was be VBD cord-015365-iqdi99pd 1915 3 analyzed analyze VBN cord-015365-iqdi99pd 1915 4 by by IN cord-015365-iqdi99pd 1915 5 ELISA ELISA NNP cord-015365-iqdi99pd 1915 6 and and CC cord-015365-iqdi99pd 1915 7 expression expression NN cord-015365-iqdi99pd 1915 8 levels level NNS cord-015365-iqdi99pd 1915 9 were be VBD cord-015365-iqdi99pd 1915 10 correlated correlate VBN cord-015365-iqdi99pd 1915 11 with with IN cord-015365-iqdi99pd 1915 12 parameters parameter NNS cord-015365-iqdi99pd 1915 13 of of IN cord-015365-iqdi99pd 1915 14 allograft allograft NN cord-015365-iqdi99pd 1915 15 rejection rejection NN cord-015365-iqdi99pd 1915 16 . . . cord-015365-iqdi99pd 1916 1 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1916 2 expression expression NN cord-015365-iqdi99pd 1916 3 was be VBD cord-015365-iqdi99pd 1916 4 further further RB cord-015365-iqdi99pd 1916 5 correlated correlate VBN cord-015365-iqdi99pd 1916 6 with with IN cord-015365-iqdi99pd 1916 7 preexistent preexistent JJ cord-015365-iqdi99pd 1916 8 malignancy malignancy NN cord-015365-iqdi99pd 1916 9 , , , cord-015365-iqdi99pd 1916 10 postoperative postoperative JJ cord-015365-iqdi99pd 1916 11 renal renal JJ cord-015365-iqdi99pd 1916 12 failure failure NN cord-015365-iqdi99pd 1916 13 and and CC cord-015365-iqdi99pd 1916 14 various various JJ cord-015365-iqdi99pd 1916 15 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 1916 16 regimens regimen NNS cord-015365-iqdi99pd 1916 17 . . . cord-015365-iqdi99pd 1917 1 Results result NNS cord-015365-iqdi99pd 1917 2 . . . cord-015365-iqdi99pd 1918 1 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1918 2 serum serum NN cord-015365-iqdi99pd 1918 3 levels level NNS cord-015365-iqdi99pd 1918 4 were be VBD cord-015365-iqdi99pd 1918 5 elevated elevate VBN cord-015365-iqdi99pd 1918 6 3 3 CD cord-015365-iqdi99pd 1918 7 to to TO cord-015365-iqdi99pd 1918 8 7 7 CD cord-015365-iqdi99pd 1918 9 fold fold VB cord-015365-iqdi99pd 1918 10 immediately immediately RB cord-015365-iqdi99pd 1918 11 after after IN cord-015365-iqdi99pd 1918 12 liver liver NN cord-015365-iqdi99pd 1918 13 transplantation transplantation NN cord-015365-iqdi99pd 1918 14 due due IN cord-015365-iqdi99pd 1918 15 to to IN cord-015365-iqdi99pd 1918 16 IRI IRI NNP cord-015365-iqdi99pd 1918 17 and and CC cord-015365-iqdi99pd 1918 18 also also RB cord-015365-iqdi99pd 1918 19 increased increase VBD cord-015365-iqdi99pd 1918 20 prior prior RB cord-015365-iqdi99pd 1918 21 to to IN cord-015365-iqdi99pd 1918 22 clinically clinically RB cord-015365-iqdi99pd 1918 23 diagnosed diagnose VBN cord-015365-iqdi99pd 1918 24 acute acute JJ cord-015365-iqdi99pd 1918 25 rejection rejection NN cord-015365-iqdi99pd 1918 26 , , , cord-015365-iqdi99pd 1918 27 however however RB cord-015365-iqdi99pd 1918 28 not not RB cord-015365-iqdi99pd 1918 29 statistically statistically RB cord-015365-iqdi99pd 1918 30 significant significant JJ cord-015365-iqdi99pd 1918 31 ( ( -LRB- cord-015365-iqdi99pd 1918 32 p p NN cord-015365-iqdi99pd 1918 33 > > XX cord-015365-iqdi99pd 1918 34 0.05 0.05 CD cord-015365-iqdi99pd 1918 35 ) ) -RRB- cord-015365-iqdi99pd 1918 36 but but CC cord-015365-iqdi99pd 1918 37 closely closely RB cord-015365-iqdi99pd 1918 38 related related JJ cord-015365-iqdi99pd 1918 39 to to IN cord-015365-iqdi99pd 1918 40 an an DT cord-015365-iqdi99pd 1918 41 elevation elevation NN cord-015365-iqdi99pd 1918 42 of of IN cord-015365-iqdi99pd 1918 43 routinely routinely RB cord-015365-iqdi99pd 1918 44 used use VBN cord-015365-iqdi99pd 1918 45 laboratory laboratory NN cord-015365-iqdi99pd 1918 46 parameters parameter NNS cord-015365-iqdi99pd 1918 47 . . . cord-015365-iqdi99pd 1919 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1919 2 . . . cord-015365-iqdi99pd 1920 1 Our -PRON- PRP$ cord-015365-iqdi99pd 1920 2 data datum NNS cord-015365-iqdi99pd 1920 3 suggest suggest VBP cord-015365-iqdi99pd 1920 4 Lcn-2 Lcn-2 NNP cord-015365-iqdi99pd 1920 5 to to TO cord-015365-iqdi99pd 1920 6 be be VB cord-015365-iqdi99pd 1920 7 a a DT cord-015365-iqdi99pd 1920 8 chemoattractant chemoattractant JJ cord-015365-iqdi99pd 1920 9 stimulus stimulus NN cord-015365-iqdi99pd 1920 10 for for IN cord-015365-iqdi99pd 1920 11 infiltrating infiltrate VBG cord-015365-iqdi99pd 1920 12 immune immune JJ cord-015365-iqdi99pd 1920 13 competent competent JJ cord-015365-iqdi99pd 1920 14 cells cell NNS cord-015365-iqdi99pd 1920 15 into into IN cord-015365-iqdi99pd 1920 16 the the DT cord-015365-iqdi99pd 1920 17 allograft allograft NN cord-015365-iqdi99pd 1920 18 following follow VBG cord-015365-iqdi99pd 1920 19 solid solid JJ cord-015365-iqdi99pd 1920 20 organ organ NN cord-015365-iqdi99pd 1920 21 transplantation transplantation NN cord-015365-iqdi99pd 1920 22 . . . cord-015365-iqdi99pd 1921 1 It -PRON- PRP cord-015365-iqdi99pd 1921 2 is be VBZ cord-015365-iqdi99pd 1921 3 an an DT cord-015365-iqdi99pd 1921 4 inflammatory inflammatory JJ cord-015365-iqdi99pd 1921 5 marker marker NN cord-015365-iqdi99pd 1921 6 which which WDT cord-015365-iqdi99pd 1921 7 is be VBZ cord-015365-iqdi99pd 1921 8 upregulated upregulate VBN cord-015365-iqdi99pd 1921 9 during during IN cord-015365-iqdi99pd 1921 10 acute acute JJ cord-015365-iqdi99pd 1921 11 graft graft NN cord-015365-iqdi99pd 1921 12 rejection rejection NN cord-015365-iqdi99pd 1921 13 and and CC cord-015365-iqdi99pd 1921 14 its -PRON- PRP$ cord-015365-iqdi99pd 1921 15 elevation elevation NN cord-015365-iqdi99pd 1921 16 prior prior RB cord-015365-iqdi99pd 1921 17 to to IN cord-015365-iqdi99pd 1921 18 routinely routinely RB cord-015365-iqdi99pd 1921 19 used use VBN cord-015365-iqdi99pd 1921 20 parameters parameter NNS cord-015365-iqdi99pd 1921 21 of of IN cord-015365-iqdi99pd 1921 22 acute acute JJ cord-015365-iqdi99pd 1921 23 rejection rejection NN cord-015365-iqdi99pd 1921 24 might may MD cord-015365-iqdi99pd 1921 25 be be VB cord-015365-iqdi99pd 1921 26 an an DT cord-015365-iqdi99pd 1921 27 important important JJ cord-015365-iqdi99pd 1921 28 tool tool NN cord-015365-iqdi99pd 1921 29 for for IN cord-015365-iqdi99pd 1921 30 therapeutic therapeutic JJ cord-015365-iqdi99pd 1921 31 intervention intervention NN cord-015365-iqdi99pd 1921 32 . . . cord-015365-iqdi99pd 1922 1 Effect effect NN cord-015365-iqdi99pd 1922 2 of of IN cord-015365-iqdi99pd 1922 3 oxidative oxidative JJ cord-015365-iqdi99pd 1922 4 stress stress NN cord-015365-iqdi99pd 1922 5 and and CC cord-015365-iqdi99pd 1922 6 endotoxin endotoxin NN cord-015365-iqdi99pd 1922 7 on on IN cord-015365-iqdi99pd 1922 8 albumin albumin NN cord-015365-iqdi99pd 1922 9 in in IN cord-015365-iqdi99pd 1922 10 brain brain NN cord-015365-iqdi99pd 1922 11 death death NN cord-015365-iqdi99pd 1922 12 Background Background NNP cord-015365-iqdi99pd 1922 13 . . . cord-015365-iqdi99pd 1923 1 Albumin albumin NN cord-015365-iqdi99pd 1923 2 binds bind VBZ cord-015365-iqdi99pd 1923 3 and and CC cord-015365-iqdi99pd 1923 4 detoxifies detoxify VBZ cord-015365-iqdi99pd 1923 5 endotoxin endotoxin NN cord-015365-iqdi99pd 1923 6 in in IN cord-015365-iqdi99pd 1923 7 healthy healthy JJ cord-015365-iqdi99pd 1923 8 people people NNS cord-015365-iqdi99pd 1923 9 . . . cord-015365-iqdi99pd 1924 1 Oxidative oxidative JJ cord-015365-iqdi99pd 1924 2 stress stress NN cord-015365-iqdi99pd 1924 3 leads lead VBZ cord-015365-iqdi99pd 1924 4 to to IN cord-015365-iqdi99pd 1924 5 protein protein NN cord-015365-iqdi99pd 1924 6 oxidation oxidation NN cord-015365-iqdi99pd 1924 7 and and CC cord-015365-iqdi99pd 1924 8 thus thus RB cord-015365-iqdi99pd 1924 9 to to IN cord-015365-iqdi99pd 1924 10 impaired impair VBN cord-015365-iqdi99pd 1924 11 binding binding JJ cord-015365-iqdi99pd 1924 12 properties property NNS cord-015365-iqdi99pd 1924 13 of of IN cord-015365-iqdi99pd 1924 14 albumin albumin NN cord-015365-iqdi99pd 1924 15 . . . cord-015365-iqdi99pd 1925 1 This this DT cord-015365-iqdi99pd 1925 2 , , , cord-015365-iqdi99pd 1925 3 in in IN cord-015365-iqdi99pd 1925 4 combination combination NN cord-015365-iqdi99pd 1925 5 with with IN cord-015365-iqdi99pd 1925 6 increased increase VBN cord-015365-iqdi99pd 1925 7 gut gut NN cord-015365-iqdi99pd 1925 8 permeability permeability NN cord-015365-iqdi99pd 1925 9 leads lead VBZ cord-015365-iqdi99pd 1925 10 to to IN cord-015365-iqdi99pd 1925 11 appearance appearance NN cord-015365-iqdi99pd 1925 12 of of IN cord-015365-iqdi99pd 1925 13 endotoxin endotoxin NN cord-015365-iqdi99pd 1925 14 in in IN cord-015365-iqdi99pd 1925 15 the the DT cord-015365-iqdi99pd 1925 16 systemic systemic JJ cord-015365-iqdi99pd 1925 17 circulation circulation NN cord-015365-iqdi99pd 1925 18 and and CC cord-015365-iqdi99pd 1925 19 further further RB cord-015365-iqdi99pd 1925 20 to to IN cord-015365-iqdi99pd 1925 21 impaired impaired JJ cord-015365-iqdi99pd 1925 22 organ organ NN cord-015365-iqdi99pd 1925 23 function function NN cord-015365-iqdi99pd 1925 24 . . . cord-015365-iqdi99pd 1926 1 We -PRON- PRP cord-015365-iqdi99pd 1926 2 hypothesise hypothesise VBP cord-015365-iqdi99pd 1926 3 that that IN cord-015365-iqdi99pd 1926 4 these these DT cord-015365-iqdi99pd 1926 5 processes process NNS cord-015365-iqdi99pd 1926 6 occur occur VBP cord-015365-iqdi99pd 1926 7 in in IN cord-015365-iqdi99pd 1926 8 serum serum NN cord-015365-iqdi99pd 1926 9 of of IN cord-015365-iqdi99pd 1926 10 brain brain NN cord-015365-iqdi99pd 1926 11 - - HYPH cord-015365-iqdi99pd 1926 12 dead dead JJ cord-015365-iqdi99pd 1926 13 organ organ NN cord-015365-iqdi99pd 1926 14 donors donor NNS cord-015365-iqdi99pd 1926 15 . . . cord-015365-iqdi99pd 1927 1 Methods method NNS cord-015365-iqdi99pd 1927 2 . . . cord-015365-iqdi99pd 1928 1 Endotoxin endotoxin NN cord-015365-iqdi99pd 1928 2 was be VBD cord-015365-iqdi99pd 1928 3 determined determine VBN cord-015365-iqdi99pd 1928 4 with with IN cord-015365-iqdi99pd 1928 5 an an DT cord-015365-iqdi99pd 1928 6 adapted adapt VBN cord-015365-iqdi99pd 1928 7 limulus limulus NNP cord-015365-iqdi99pd 1928 8 amoebocyte amoebocyte NNP cord-015365-iqdi99pd 1928 9 lysate lysate NN cord-015365-iqdi99pd 1928 10 assay assay NN cord-015365-iqdi99pd 1928 11 . . . cord-015365-iqdi99pd 1929 1 Albumin albumin NN cord-015365-iqdi99pd 1929 2 fractions fraction NNS cord-015365-iqdi99pd 1929 3 and and CC cord-015365-iqdi99pd 1929 4 binding bind VBG cord-015365-iqdi99pd 1929 5 capacity capacity NN cord-015365-iqdi99pd 1929 6 were be VBD cord-015365-iqdi99pd 1929 7 determined determine VBN cord-015365-iqdi99pd 1929 8 by by IN cord-015365-iqdi99pd 1929 9 HPLC HPLC NNP cord-015365-iqdi99pd 1929 10 . . . cord-015365-iqdi99pd 1930 1 FlowCytomixTM FlowCytomixTM NNP cord-015365-iqdi99pd 1930 2 was be VBD cord-015365-iqdi99pd 1930 3 used use VBN cord-015365-iqdi99pd 1930 4 for for IN cord-015365-iqdi99pd 1930 5 determination determination NN cord-015365-iqdi99pd 1930 6 of of IN cord-015365-iqdi99pd 1930 7 cytokine cytokine NN cord-015365-iqdi99pd 1930 8 levels level NNS cord-015365-iqdi99pd 1930 9 . . . cord-015365-iqdi99pd 1931 1 Results result NNS cord-015365-iqdi99pd 1931 2 . . . cord-015365-iqdi99pd 1932 1 Eighty eighty CD cord-015365-iqdi99pd 1932 2 - - HYPH cord-015365-iqdi99pd 1932 3 four four CD cord-015365-iqdi99pd 1932 4 brain brain NN cord-015365-iqdi99pd 1932 5 - - HYPH cord-015365-iqdi99pd 1932 6 dead dead JJ cord-015365-iqdi99pd 1932 7 organ organ NN cord-015365-iqdi99pd 1932 8 donors donor NNS cord-015365-iqdi99pd 1932 9 were be VBD cord-015365-iqdi99pd 1932 10 enrolled enrol VBN cord-015365-iqdi99pd 1932 11 and and CC cord-015365-iqdi99pd 1932 12 categorized categorize VBN cord-015365-iqdi99pd 1932 13 by by IN cord-015365-iqdi99pd 1932 14 the the DT cord-015365-iqdi99pd 1932 15 length length NN cord-015365-iqdi99pd 1932 16 of of IN cord-015365-iqdi99pd 1932 17 intensive intensive JJ cord-015365-iqdi99pd 1932 18 care care NN cord-015365-iqdi99pd 1932 19 unit unit NN cord-015365-iqdi99pd 1932 20 ( ( -LRB- cord-015365-iqdi99pd 1932 21 ICU ICU NNP cord-015365-iqdi99pd 1932 22 ) ) -RRB- cord-015365-iqdi99pd 1932 23 stay stay VBP cord-015365-iqdi99pd 1932 24 . . . cord-015365-iqdi99pd 1933 1 Albumin albumin NN cord-015365-iqdi99pd 1933 2 binding binding NN cord-015365-iqdi99pd 1933 3 capacity capacity NN cord-015365-iqdi99pd 1933 4 for for IN cord-015365-iqdi99pd 1933 5 dansylsarcosine dansylsarcosine NN cord-015365-iqdi99pd 1933 6 was be VBD cord-015365-iqdi99pd 1933 7 reduced reduce VBN cord-015365-iqdi99pd 1933 8 in in IN cord-015365-iqdi99pd 1933 9 brain brain NN cord-015365-iqdi99pd 1933 10 - - HYPH cord-015365-iqdi99pd 1933 11 dead dead JJ cord-015365-iqdi99pd 1933 12 patients patient NNS cord-015365-iqdi99pd 1933 13 compared compare VBN cord-015365-iqdi99pd 1933 14 to to IN cord-015365-iqdi99pd 1933 15 controls control NNS cord-015365-iqdi99pd 1933 16 . . . cord-015365-iqdi99pd 1934 1 Endotoxin endotoxin NN cord-015365-iqdi99pd 1934 2 positivity positivity NN cord-015365-iqdi99pd 1934 3 in in IN cord-015365-iqdi99pd 1934 4 16.7 16.7 CD cord-015365-iqdi99pd 1934 5 % % NN cord-015365-iqdi99pd 1934 6 of of IN cord-015365-iqdi99pd 1934 7 donors donor NNS cord-015365-iqdi99pd 1934 8 was be VBD cord-015365-iqdi99pd 1934 9 associated associate VBN cord-015365-iqdi99pd 1934 10 with with IN cord-015365-iqdi99pd 1934 11 decreased decrease VBN cord-015365-iqdi99pd 1934 12 binding bind VBG cord-015365-iqdi99pd 1934 13 capacity capacity NN cord-015365-iqdi99pd 1934 14 in in IN cord-015365-iqdi99pd 1934 15 donors donor NNS cord-015365-iqdi99pd 1934 16 and and CC cord-015365-iqdi99pd 1934 17 worse bad JJR cord-015365-iqdi99pd 1934 18 survival survival NN cord-015365-iqdi99pd 1934 19 of of IN cord-015365-iqdi99pd 1934 20 recipients recipient NNS cord-015365-iqdi99pd 1934 21 . . . cord-015365-iqdi99pd 1935 1 Lengths Lengths NNP cord-015365-iqdi99pd 1935 2 of of IN cord-015365-iqdi99pd 1935 3 ICU ICU NNP cord-015365-iqdi99pd 1935 4 stay stay NN cord-015365-iqdi99pd 1935 5 increased increase VBN cord-015365-iqdi99pd 1935 6 albumin albumin NN cord-015365-iqdi99pd 1935 7 oxidation oxidation NN cord-015365-iqdi99pd 1935 8 . . . cord-015365-iqdi99pd 1936 1 In in IN cord-015365-iqdi99pd 1936 2 addition addition NN cord-015365-iqdi99pd 1936 3 , , , cord-015365-iqdi99pd 1936 4 IL-6 IL-6 NNP cord-015365-iqdi99pd 1936 5 , , , cord-015365-iqdi99pd 1936 6 IL-8 IL-8 NNP cord-015365-iqdi99pd 1936 7 , , , cord-015365-iqdi99pd 1936 8 IL-10 IL-10 NNP cord-015365-iqdi99pd 1936 9 and and CC cord-015365-iqdi99pd 1936 10 IL-1 IL-1 NNP cord-015365-iqdi99pd 1936 11 levels level NNS cord-015365-iqdi99pd 1936 12 were be VBD cord-015365-iqdi99pd 1936 13 elevated elevate VBN cord-015365-iqdi99pd 1936 14 in in IN cord-015365-iqdi99pd 1936 15 patients patient NNS cord-015365-iqdi99pd 1936 16 , , , cord-015365-iqdi99pd 1936 17 whereas whereas IN cord-015365-iqdi99pd 1936 18 IFN IFN NNP cord-015365-iqdi99pd 1936 19 - - HYPH cord-015365-iqdi99pd 1936 20 levels level NNS cord-015365-iqdi99pd 1936 21 were be VBD cord-015365-iqdi99pd 1936 22 within within IN cord-015365-iqdi99pd 1936 23 the the DT cord-015365-iqdi99pd 1936 24 normal normal JJ cord-015365-iqdi99pd 1936 25 range range NN cord-015365-iqdi99pd 1936 26 . . . cord-015365-iqdi99pd 1937 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1937 2 . . . cord-015365-iqdi99pd 1938 1 We -PRON- PRP cord-015365-iqdi99pd 1938 2 conclude conclude VBP cord-015365-iqdi99pd 1938 3 that that IN cord-015365-iqdi99pd 1938 4 oxidative oxidative JJ cord-015365-iqdi99pd 1938 5 stress stress NN cord-015365-iqdi99pd 1938 6 and and CC cord-015365-iqdi99pd 1938 7 systemic systemic JJ cord-015365-iqdi99pd 1938 8 endotoxemia endotoxemia NN cord-015365-iqdi99pd 1938 9 is be VBZ cord-015365-iqdi99pd 1938 10 present present JJ cord-015365-iqdi99pd 1938 11 in in IN cord-015365-iqdi99pd 1938 12 brain brain NN cord-015365-iqdi99pd 1938 13 - - HYPH cord-015365-iqdi99pd 1938 14 dead dead JJ cord-015365-iqdi99pd 1938 15 organ organ NN cord-015365-iqdi99pd 1938 16 donors donor NNS cord-015365-iqdi99pd 1938 17 what what WP cord-015365-iqdi99pd 1938 18 might may MD cord-015365-iqdi99pd 1938 19 affect affect VB cord-015365-iqdi99pd 1938 20 recipient recipient NN cord-015365-iqdi99pd 1938 21 survival survival NN cord-015365-iqdi99pd 1938 22 . . . cord-015365-iqdi99pd 1939 1 High high JJ cord-015365-iqdi99pd 1939 2 endotoxin endotoxin NN cord-015365-iqdi99pd 1939 3 levels level NNS cord-015365-iqdi99pd 1939 4 might may MD cord-015365-iqdi99pd 1939 5 be be VB cord-015365-iqdi99pd 1939 6 due due JJ cord-015365-iqdi99pd 1939 7 to to IN cord-015365-iqdi99pd 1939 8 increased increase VBN cord-015365-iqdi99pd 1939 9 gut gut NN cord-015365-iqdi99pd 1939 10 permeability permeability NN cord-015365-iqdi99pd 1939 11 and and CC cord-015365-iqdi99pd 1939 12 decreased decrease VBD cord-015365-iqdi99pd 1939 13 binding bind VBG cord-015365-iqdi99pd 1939 14 capacity capacity NN cord-015365-iqdi99pd 1939 15 of of IN cord-015365-iqdi99pd 1939 16 albumin albumin NN cord-015365-iqdi99pd 1939 17 influenced influence VBN cord-015365-iqdi99pd 1939 18 not not RB cord-015365-iqdi99pd 1939 19 only only RB cord-015365-iqdi99pd 1939 20 by by IN cord-015365-iqdi99pd 1939 21 higher high JJR cord-015365-iqdi99pd 1939 22 albumin albumin NN cord-015365-iqdi99pd 1939 23 oxidation oxidation NN cord-015365-iqdi99pd 1939 24 . . . cord-015365-iqdi99pd 1940 1 Evidence evidence NN cord-015365-iqdi99pd 1940 2 of of IN cord-015365-iqdi99pd 1940 3 lymphoid lymphoid JJ cord-015365-iqdi99pd 1940 4 neogenesis neogenesis NN cord-015365-iqdi99pd 1940 5 in in IN cord-015365-iqdi99pd 1940 6 skin skin NN cord-015365-iqdi99pd 1940 7 biopsies biopsy NNS cord-015365-iqdi99pd 1940 8 of of IN cord-015365-iqdi99pd 1940 9 human human JJ cord-015365-iqdi99pd 1940 10 hand hand NN cord-015365-iqdi99pd 1940 11 allografts allograft NNS cord-015365-iqdi99pd 1940 12 during during IN cord-015365-iqdi99pd 1940 13 rejection rejection NN cord-015365-iqdi99pd 1940 14 Background Background NNP cord-015365-iqdi99pd 1940 15 . . . cord-015365-iqdi99pd 1941 1 Excessive excessive JJ cord-015365-iqdi99pd 1941 2 production production NN cord-015365-iqdi99pd 1941 3 of of IN cord-015365-iqdi99pd 1941 4 reactive reactive JJ cord-015365-iqdi99pd 1941 5 oxygen oxygen NN cord-015365-iqdi99pd 1941 6 species specie NNS cord-015365-iqdi99pd 1942 1 ( ( -LRB- cord-015365-iqdi99pd 1942 2 ROS ROS NNP cord-015365-iqdi99pd 1942 3 ) ) -RRB- cord-015365-iqdi99pd 1942 4 is be VBZ cord-015365-iqdi99pd 1942 5 a a DT cord-015365-iqdi99pd 1942 6 major major JJ cord-015365-iqdi99pd 1942 7 contributor contributor NN cord-015365-iqdi99pd 1942 8 to to IN cord-015365-iqdi99pd 1942 9 the the DT cord-015365-iqdi99pd 1942 10 development development NN cord-015365-iqdi99pd 1942 11 of of IN cord-015365-iqdi99pd 1942 12 ischemia ischemia NN cord-015365-iqdi99pd 1942 13 - - HYPH cord-015365-iqdi99pd 1942 14 reperfusion reperfusion NN cord-015365-iqdi99pd 1942 15 injury injury NN cord-015365-iqdi99pd 1942 16 ( ( -LRB- cord-015365-iqdi99pd 1942 17 IRI IRI NNP cord-015365-iqdi99pd 1942 18 ) ) -RRB- cord-015365-iqdi99pd 1942 19 in in IN cord-015365-iqdi99pd 1942 20 the the DT cord-015365-iqdi99pd 1942 21 course course NN cord-015365-iqdi99pd 1942 22 of of IN cord-015365-iqdi99pd 1942 23 solid solid JJ cord-015365-iqdi99pd 1942 24 organ organ NN cord-015365-iqdi99pd 1942 25 transplantation transplantation NN cord-015365-iqdi99pd 1942 26 . . . cord-015365-iqdi99pd 1943 1 In in IN cord-015365-iqdi99pd 1943 2 particular particular JJ cord-015365-iqdi99pd 1943 3 mitochondria mitochondria NN cord-015365-iqdi99pd 1943 4 - - HYPH cord-015365-iqdi99pd 1943 5 derived derive VBN cord-015365-iqdi99pd 1943 6 ROS ROS NNP cord-015365-iqdi99pd 1943 7 are be VBP cord-015365-iqdi99pd 1943 8 critical critical JJ cord-015365-iqdi99pd 1943 9 for for IN cord-015365-iqdi99pd 1943 10 the the DT cord-015365-iqdi99pd 1943 11 initiation initiation NN cord-015365-iqdi99pd 1943 12 and and CC cord-015365-iqdi99pd 1943 13 progression progression NN cord-015365-iqdi99pd 1943 14 of of IN cord-015365-iqdi99pd 1943 15 IRI IRI NNP cord-015365-iqdi99pd 1943 16 , , , cord-015365-iqdi99pd 1943 17 which which WDT cord-015365-iqdi99pd 1943 18 restricts restrict VBZ cord-015365-iqdi99pd 1943 19 the the DT cord-015365-iqdi99pd 1943 20 pool pool NN cord-015365-iqdi99pd 1943 21 of of IN cord-015365-iqdi99pd 1943 22 donor donor NN cord-015365-iqdi99pd 1943 23 organs organ NNS cord-015365-iqdi99pd 1943 24 and and CC cord-015365-iqdi99pd 1943 25 results result NNS cord-015365-iqdi99pd 1943 26 in in IN cord-015365-iqdi99pd 1943 27 elaborate elaborate JJ cord-015365-iqdi99pd 1943 28 follow follow NN cord-015365-iqdi99pd 1943 29 up up RP cord-015365-iqdi99pd 1943 30 treatments treatment NNS cord-015365-iqdi99pd 1943 31 . . . cord-015365-iqdi99pd 1944 1 In in IN cord-015365-iqdi99pd 1944 2 various various JJ cord-015365-iqdi99pd 1944 3 in in IN cord-015365-iqdi99pd 1944 4 vivo vivo FW cord-015365-iqdi99pd 1944 5 ( ( -LRB- cord-015365-iqdi99pd 1944 6 IR IR NNP cord-015365-iqdi99pd 1944 7 ) ) -RRB- cord-015365-iqdi99pd 1944 8 and and CC cord-015365-iqdi99pd 1944 9 in in IN cord-015365-iqdi99pd 1944 10 vitro vitro FW cord-015365-iqdi99pd 1944 11 ( ( -LRB- cord-015365-iqdi99pd 1944 12 hypoxia hypoxia NN cord-015365-iqdi99pd 1944 13 / / SYM cord-015365-iqdi99pd 1944 14 reoxygenation reoxygenation NN cord-015365-iqdi99pd 1944 15 , , , cord-015365-iqdi99pd 1944 16 HR HR NNP cord-015365-iqdi99pd 1944 17 ) ) -RRB- cord-015365-iqdi99pd 1944 18 models model NNS cord-015365-iqdi99pd 1944 19 we -PRON- PRP cord-015365-iqdi99pd 1944 20 observed observe VBD cord-015365-iqdi99pd 1944 21 a a DT cord-015365-iqdi99pd 1944 22 consistent consistent JJ cord-015365-iqdi99pd 1944 23 pattern pattern NN cord-015365-iqdi99pd 1944 24 in in IN cord-015365-iqdi99pd 1944 25 the the DT cord-015365-iqdi99pd 1944 26 activation activation NN cord-015365-iqdi99pd 1944 27 of of IN cord-015365-iqdi99pd 1944 28 key key JJ cord-015365-iqdi99pd 1944 29 intracellular intracellular JJ cord-015365-iqdi99pd 1944 30 signaling signal VBG cord-015365-iqdi99pd 1944 31 pathways pathway NNS cord-015365-iqdi99pd 1944 32 . . . cord-015365-iqdi99pd 1945 1 Most most RBS cord-015365-iqdi99pd 1945 2 strikingly strikingly RB cord-015365-iqdi99pd 1945 3 the the DT cord-015365-iqdi99pd 1945 4 use use NN cord-015365-iqdi99pd 1945 5 of of IN cord-015365-iqdi99pd 1945 6 p38 p38 CD cord-015365-iqdi99pd 1945 7 specific specific JJ cord-015365-iqdi99pd 1945 8 inhibitors inhibitor NNS cord-015365-iqdi99pd 1945 9 prevented prevent VBD cord-015365-iqdi99pd 1945 10 mitochondrial mitochondrial JJ cord-015365-iqdi99pd 1945 11 ROS ROS NNP cord-015365-iqdi99pd 1945 12 production production NN cord-015365-iqdi99pd 1945 13 and and CC cord-015365-iqdi99pd 1945 14 cell cell NN cord-015365-iqdi99pd 1945 15 death death NN cord-015365-iqdi99pd 1945 16 . . . cord-015365-iqdi99pd 1946 1 Here here RB cord-015365-iqdi99pd 1946 2 we -PRON- PRP cord-015365-iqdi99pd 1946 3 further further RB cord-015365-iqdi99pd 1946 4 dissected dissect VBD cord-015365-iqdi99pd 1946 5 the the DT cord-015365-iqdi99pd 1946 6 contribution contribution NN cord-015365-iqdi99pd 1946 7 of of IN cord-015365-iqdi99pd 1946 8 p38 p38 CD cord-015365-iqdi99pd 1946 9 to to IN cord-015365-iqdi99pd 1946 10 IR IR NNP cord-015365-iqdi99pd 1946 11 - - : cord-015365-iqdi99pd 1946 12 and and CC cord-015365-iqdi99pd 1946 13 HR hr NN cord-015365-iqdi99pd 1946 14 - - HYPH cord-015365-iqdi99pd 1946 15 induced induce VBN cord-015365-iqdi99pd 1946 16 damage damage NN cord-015365-iqdi99pd 1946 17 and and CC cord-015365-iqdi99pd 1946 18 provide provide VB cord-015365-iqdi99pd 1946 19 first first JJ cord-015365-iqdi99pd 1946 20 evidence evidence NN cord-015365-iqdi99pd 1946 21 for for IN cord-015365-iqdi99pd 1946 22 a a DT cord-015365-iqdi99pd 1946 23 therapeutic therapeutic JJ cord-015365-iqdi99pd 1946 24 benefit benefit NN cord-015365-iqdi99pd 1946 25 of of IN cord-015365-iqdi99pd 1946 26 p38 p38 CD cord-015365-iqdi99pd 1946 27 inhibition inhibition NN cord-015365-iqdi99pd 1946 28 by by IN cord-015365-iqdi99pd 1946 29 BIRB-796 BIRB-796 NNP cord-015365-iqdi99pd 1946 30 in in IN cord-015365-iqdi99pd 1946 31 vivo vivo NN cord-015365-iqdi99pd 1946 32 . . . cord-015365-iqdi99pd 1947 1 Methods method NNS cord-015365-iqdi99pd 1947 2 . . . cord-015365-iqdi99pd 1948 1 Kidney kidney NN cord-015365-iqdi99pd 1948 2 transplantation transplantation NN cord-015365-iqdi99pd 1948 3 and and CC cord-015365-iqdi99pd 1948 4 kidney kidney NN cord-015365-iqdi99pd 1948 5 clamping clamp VBG cord-015365-iqdi99pd 1948 6 in in IN cord-015365-iqdi99pd 1948 7 the the DT cord-015365-iqdi99pd 1948 8 rat rat NN cord-015365-iqdi99pd 1948 9 were be VBD cord-015365-iqdi99pd 1948 10 used use VBN cord-015365-iqdi99pd 1948 11 for for IN cord-015365-iqdi99pd 1948 12 the the DT cord-015365-iqdi99pd 1948 13 induction induction NN cord-015365-iqdi99pd 1948 14 of of IN cord-015365-iqdi99pd 1948 15 IRI IRI NNP cord-015365-iqdi99pd 1948 16 . . . cord-015365-iqdi99pd 1949 1 H H NNP cord-015365-iqdi99pd 1949 2 / / SYM cord-015365-iqdi99pd 1949 3 R r NN cord-015365-iqdi99pd 1949 4 was be VBD cord-015365-iqdi99pd 1949 5 analyzed analyze VBN cord-015365-iqdi99pd 1949 6 in in IN cord-015365-iqdi99pd 1949 7 HL-1 HL-1 NNP cord-015365-iqdi99pd 1949 8 cardiomyocytes cardiomyocyte NNS cord-015365-iqdi99pd 1949 9 and and CC cord-015365-iqdi99pd 1949 10 primary primary JJ cord-015365-iqdi99pd 1949 11 MEFs mef NNS cord-015365-iqdi99pd 1949 12 . . . cord-015365-iqdi99pd 1950 1 Intracellular Intracellular NNP cord-015365-iqdi99pd 1950 2 signaling signaling NN cord-015365-iqdi99pd 1950 3 was be VBD cord-015365-iqdi99pd 1950 4 monitored monitor VBN cord-015365-iqdi99pd 1950 5 by by IN cord-015365-iqdi99pd 1950 6 using use VBG cord-015365-iqdi99pd 1950 7 phosphorylation phosphorylation JJ cord-015365-iqdi99pd 1950 8 specific specific JJ cord-015365-iqdi99pd 1950 9 antibodies antibody NNS cord-015365-iqdi99pd 1950 10 . . . cord-015365-iqdi99pd 1951 1 Mitochondrial mitochondrial JJ cord-015365-iqdi99pd 1951 2 ROS ROS NNP cord-015365-iqdi99pd 1951 3 levels level NNS cord-015365-iqdi99pd 1951 4 were be VBD cord-015365-iqdi99pd 1951 5 determined determine VBN cord-015365-iqdi99pd 1951 6 by by IN cord-015365-iqdi99pd 1951 7 imaging image VBG cord-015365-iqdi99pd 1951 8 of of IN cord-015365-iqdi99pd 1951 9 Mitotracker Mitotracker NNP cord-015365-iqdi99pd 1951 10 Red Red NNP cord-015365-iqdi99pd 1951 11 CM- CM- NNP cord-015365-iqdi99pd 1952 1 H2XROS H2XROS NNP cord-015365-iqdi99pd 1952 2 . . . cord-015365-iqdi99pd 1953 1 ROS ROS NNP cord-015365-iqdi99pd 1953 2 / / SYM cord-015365-iqdi99pd 1953 3 NOS NOS NNP cord-015365-iqdi99pd 1953 4 - - HYPH cord-015365-iqdi99pd 1953 5 induced induce VBN cord-015365-iqdi99pd 1953 6 tissue tissue NN cord-015365-iqdi99pd 1953 7 damage damage NN cord-015365-iqdi99pd 1953 8 was be VBD cord-015365-iqdi99pd 1953 9 visualized visualize VBN cord-015365-iqdi99pd 1953 10 by by IN cord-015365-iqdi99pd 1953 11 3-nitrotyrosine 3-nitrotyrosine CD cord-015365-iqdi99pd 1953 12 specific specific JJ cord-015365-iqdi99pd 1953 13 antibodies antibody NNS cord-015365-iqdi99pd 1953 14 . . . cord-015365-iqdi99pd 1954 1 To to TO cord-015365-iqdi99pd 1954 2 assess assess VB cord-015365-iqdi99pd 1954 3 acute acute JJ cord-015365-iqdi99pd 1954 4 kidney kidney NN cord-015365-iqdi99pd 1954 5 injury injury NN cord-015365-iqdi99pd 1954 6 ( ( -LRB- cord-015365-iqdi99pd 1954 7 AKI AKI NNP cord-015365-iqdi99pd 1954 8 ) ) -RRB- cord-015365-iqdi99pd 1955 1 HSP70 HSP70 NNP cord-015365-iqdi99pd 1955 2 expression expression NN cord-015365-iqdi99pd 1955 3 was be VBD cord-015365-iqdi99pd 1955 4 monitored monitor VBN cord-015365-iqdi99pd 1955 5 by by IN cord-015365-iqdi99pd 1955 6 immunoblotting immunoblotte VBG cord-015365-iqdi99pd 1955 7 , , , cord-015365-iqdi99pd 1955 8 serum serum NN cord-015365-iqdi99pd 1955 9 creatinine creatinine NN cord-015365-iqdi99pd 1955 10 and and CC cord-015365-iqdi99pd 1955 11 urea urea NN cord-015365-iqdi99pd 1955 12 were be VBD cord-015365-iqdi99pd 1955 13 determined determine VBN cord-015365-iqdi99pd 1955 14 , , , cord-015365-iqdi99pd 1955 15 and and CC cord-015365-iqdi99pd 1955 16 serum serum NN cord-015365-iqdi99pd 1955 17 cystatin cystatin NNP cord-015365-iqdi99pd 1955 18 c c NNP cord-015365-iqdi99pd 1955 19 and and CC cord-015365-iqdi99pd 1955 20 NGAL NGAL NNP cord-015365-iqdi99pd 1955 21 concentrations concentration NNS cord-015365-iqdi99pd 1955 22 were be VBD cord-015365-iqdi99pd 1955 23 measured measure VBN cord-015365-iqdi99pd 1955 24 by by IN cord-015365-iqdi99pd 1955 25 ELISA ELISA NNP cord-015365-iqdi99pd 1955 26 . . . cord-015365-iqdi99pd 1956 1 Results result NNS cord-015365-iqdi99pd 1956 2 . . . cord-015365-iqdi99pd 1957 1 The the DT cord-015365-iqdi99pd 1957 2 expression expression NN cord-015365-iqdi99pd 1957 3 patterns pattern NNS cord-015365-iqdi99pd 1957 4 for for IN cord-015365-iqdi99pd 1957 5 all all DT cord-015365-iqdi99pd 1957 6 p38 p38 CD cord-015365-iqdi99pd 1957 7 isoforms isoform NNS cord-015365-iqdi99pd 1957 8 were be VBD cord-015365-iqdi99pd 1957 9 established establish VBN cord-015365-iqdi99pd 1957 10 in in IN cord-015365-iqdi99pd 1957 11 HL-1 HL-1 NNP cord-015365-iqdi99pd 1957 12 cells cell NNS cord-015365-iqdi99pd 1957 13 and and CC cord-015365-iqdi99pd 1957 14 siRNA sirna NN cord-015365-iqdi99pd 1957 15 - - HYPH cord-015365-iqdi99pd 1957 16 mediated mediate VBN cord-015365-iqdi99pd 1957 17 knockdown knockdown NN cord-015365-iqdi99pd 1957 18 of of IN cord-015365-iqdi99pd 1957 19 the the DT cord-015365-iqdi99pd 1957 20 predominant predominant JJ cord-015365-iqdi99pd 1957 21 isoform isoform NN cord-015365-iqdi99pd 1957 22 ( ( -LRB- cord-015365-iqdi99pd 1957 23 p38Alpha p38alpha UH cord-015365-iqdi99pd 1957 24 ) ) -RRB- cord-015365-iqdi99pd 1957 25 reduced reduce VBN cord-015365-iqdi99pd 1957 26 ROS ROS NNP cord-015365-iqdi99pd 1957 27 production production NN cord-015365-iqdi99pd 1957 28 , , , cord-015365-iqdi99pd 1957 29 confirming confirm VBG cord-015365-iqdi99pd 1957 30 the the DT cord-015365-iqdi99pd 1957 31 critical critical JJ cord-015365-iqdi99pd 1957 32 role role NN cord-015365-iqdi99pd 1957 33 of of IN cord-015365-iqdi99pd 1957 34 p38 p38 CD cord-015365-iqdi99pd 1957 35 . . . cord-015365-iqdi99pd 1958 1 Preliminary preliminary JJ cord-015365-iqdi99pd 1958 2 data datum NNS cord-015365-iqdi99pd 1958 3 suggested suggest VBD cord-015365-iqdi99pd 1958 4 the the DT cord-015365-iqdi99pd 1958 5 requirement requirement NN cord-015365-iqdi99pd 1958 6 of of IN cord-015365-iqdi99pd 1958 7 MAPKAP MAPKAP NNP cord-015365-iqdi99pd 1958 8 kinase kinase NNP cord-015365-iqdi99pd 1958 9 2 2 CD cord-015365-iqdi99pd 1958 10 ( ( -LRB- cord-015365-iqdi99pd 1958 11 MK2 MK2 NNP cord-015365-iqdi99pd 1958 12 ) ) -RRB- cord-015365-iqdi99pd 1958 13 rather rather RB cord-015365-iqdi99pd 1958 14 than than IN cord-015365-iqdi99pd 1958 15 the the DT cord-015365-iqdi99pd 1958 16 transcription transcription NN cord-015365-iqdi99pd 1958 17 factor factor NN cord-015365-iqdi99pd 1958 18 ATF-2 ATF-2 NNP cord-015365-iqdi99pd 1958 19 downstream downstream RB cord-015365-iqdi99pd 1958 20 of of IN cord-015365-iqdi99pd 1958 21 p38 p38 CD cord-015365-iqdi99pd 1958 22 . . . cord-015365-iqdi99pd 1959 1 As as IN cord-015365-iqdi99pd 1959 2 observed observe VBN cord-015365-iqdi99pd 1959 3 in in IN cord-015365-iqdi99pd 1959 4 other other JJ cord-015365-iqdi99pd 1959 5 settings setting NNS cord-015365-iqdi99pd 1959 6 reperfusion reperfusion NN cord-015365-iqdi99pd 1959 7 following follow VBG cord-015365-iqdi99pd 1959 8 kidney kidney NN cord-015365-iqdi99pd 1959 9 clamping clamp VBG cord-015365-iqdi99pd 1959 10 or or CC cord-015365-iqdi99pd 1959 11 transplantation transplantation NN cord-015365-iqdi99pd 1959 12 was be VBD cord-015365-iqdi99pd 1959 13 marked mark VBN cord-015365-iqdi99pd 1959 14 by by IN cord-015365-iqdi99pd 1959 15 a a DT cord-015365-iqdi99pd 1959 16 profound profound JJ cord-015365-iqdi99pd 1959 17 increase increase NN cord-015365-iqdi99pd 1959 18 in in IN cord-015365-iqdi99pd 1959 19 the the DT cord-015365-iqdi99pd 1959 20 activity activity NN cord-015365-iqdi99pd 1959 21 of of IN cord-015365-iqdi99pd 1959 22 p38 p38 CD cord-015365-iqdi99pd 1959 23 , , , cord-015365-iqdi99pd 1959 24 its -PRON- PRP$ cord-015365-iqdi99pd 1959 25 upstream upstream JJ cord-015365-iqdi99pd 1959 26 kinases kinase NNS cord-015365-iqdi99pd 1959 27 MKK3/6 mkk3/6 IN cord-015365-iqdi99pd 1959 28 and and CC cord-015365-iqdi99pd 1959 29 the the DT cord-015365-iqdi99pd 1959 30 putative putative JJ cord-015365-iqdi99pd 1959 31 effector effector NN cord-015365-iqdi99pd 1959 32 MK2 MK2 NNP cord-015365-iqdi99pd 1959 33 . . . cord-015365-iqdi99pd 1960 1 Application application NN cord-015365-iqdi99pd 1960 2 of of IN cord-015365-iqdi99pd 1960 3 BIRB-796 birb-796 NN cord-015365-iqdi99pd 1960 4 prevented prevent VBD cord-015365-iqdi99pd 1960 5 deterioration deterioration NN cord-015365-iqdi99pd 1960 6 of of IN cord-015365-iqdi99pd 1960 7 kidney kidney NN cord-015365-iqdi99pd 1960 8 function function NN cord-015365-iqdi99pd 1960 9 following follow VBG cord-015365-iqdi99pd 1960 10 IR IR NNP cord-015365-iqdi99pd 1960 11 based base VBN cord-015365-iqdi99pd 1960 12 on on IN cord-015365-iqdi99pd 1960 13 reduced reduce VBN cord-015365-iqdi99pd 1960 14 serum serum NN cord-015365-iqdi99pd 1960 15 creatinine creatinine NN cord-015365-iqdi99pd 1960 16 , , , cord-015365-iqdi99pd 1960 17 urea urea NN cord-015365-iqdi99pd 1960 18 , , , cord-015365-iqdi99pd 1960 19 cystatin cystatin NNP cord-015365-iqdi99pd 1960 20 c c NN cord-015365-iqdi99pd 1960 21 and and CC cord-015365-iqdi99pd 1960 22 NGAL NGAL NNP cord-015365-iqdi99pd 1960 23 levels level NNS cord-015365-iqdi99pd 1960 24 in in IN cord-015365-iqdi99pd 1960 25 animals animal NNS cord-015365-iqdi99pd 1960 26 treated treat VBN cord-015365-iqdi99pd 1960 27 with with IN cord-015365-iqdi99pd 1960 28 the the DT cord-015365-iqdi99pd 1960 29 inhibitor inhibitor NN cord-015365-iqdi99pd 1960 30 . . . cord-015365-iqdi99pd 1961 1 P38 P38 NNP cord-015365-iqdi99pd 1961 2 inhibition inhibition NN cord-015365-iqdi99pd 1961 3 also also RB cord-015365-iqdi99pd 1961 4 protected protect VBN cord-015365-iqdi99pd 1961 5 from from IN cord-015365-iqdi99pd 1961 6 oxidative oxidative JJ cord-015365-iqdi99pd 1961 7 damage damage NN cord-015365-iqdi99pd 1961 8 . . . cord-015365-iqdi99pd 1962 1 Thus thus RB cord-015365-iqdi99pd 1962 2 the the DT cord-015365-iqdi99pd 1962 3 inhibition inhibition NN cord-015365-iqdi99pd 1962 4 of of IN cord-015365-iqdi99pd 1962 5 p38 p38 NNP cord-015365-iqdi99pd 1962 6 prevents prevent VBZ cord-015365-iqdi99pd 1962 7 key key JJ cord-015365-iqdi99pd 1962 8 processes process NNS cord-015365-iqdi99pd 1962 9 , , , cord-015365-iqdi99pd 1962 10 which which WDT cord-015365-iqdi99pd 1962 11 are be VBP cord-015365-iqdi99pd 1962 12 essential essential JJ cord-015365-iqdi99pd 1962 13 for for IN cord-015365-iqdi99pd 1962 14 the the DT cord-015365-iqdi99pd 1962 15 development development NN cord-015365-iqdi99pd 1962 16 of of IN cord-015365-iqdi99pd 1962 17 IRI IRI NNP cord-015365-iqdi99pd 1962 18 . . . cord-015365-iqdi99pd 1963 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1963 2 . . . cord-015365-iqdi99pd 1964 1 Inhibiting inhibit VBG cord-015365-iqdi99pd 1964 2 p38 p38 JJ cord-015365-iqdi99pd 1964 3 signaling signal VBG cord-015365-iqdi99pd 1964 4 during during IN cord-015365-iqdi99pd 1964 5 IR IR NNP cord-015365-iqdi99pd 1964 6 and and CC cord-015365-iqdi99pd 1964 7 HR HR NNP cord-015365-iqdi99pd 1964 8 may may MD cord-015365-iqdi99pd 1964 9 provide provide VB cord-015365-iqdi99pd 1964 10 a a DT cord-015365-iqdi99pd 1964 11 potent potent JJ cord-015365-iqdi99pd 1964 12 strategy strategy NN cord-015365-iqdi99pd 1964 13 for for IN cord-015365-iqdi99pd 1964 14 limiting limit VBG cord-015365-iqdi99pd 1964 15 IRI IRI NNP cord-015365-iqdi99pd 1964 16 . . . cord-015365-iqdi99pd 1965 1 The the DT cord-015365-iqdi99pd 1965 2 role role NN cord-015365-iqdi99pd 1965 3 of of IN cord-015365-iqdi99pd 1965 4 constitutively constitutively RB cord-015365-iqdi99pd 1965 5 expressed express VBN cord-015365-iqdi99pd 1965 6 nitric nitric JJ cord-015365-iqdi99pd 1965 7 oxide oxide NN cord-015365-iqdi99pd 1965 8 synthases synthase NNS cord-015365-iqdi99pd 1965 9 in in IN cord-015365-iqdi99pd 1965 10 ischemiareperfusion ischemiareperfusion NN cord-015365-iqdi99pd 1965 11 - - HYPH cord-015365-iqdi99pd 1965 12 injury injury NN cord-015365-iqdi99pd 1965 13 Background background NN cord-015365-iqdi99pd 1965 14 . . . cord-015365-iqdi99pd 1966 1 Single single JJ cord-015365-iqdi99pd 1966 2 shot shot JJ cord-015365-iqdi99pd 1966 3 donor donor NN cord-015365-iqdi99pd 1966 4 therapy therapy NN cord-015365-iqdi99pd 1966 5 with with IN cord-015365-iqdi99pd 1966 6 the the DT cord-015365-iqdi99pd 1966 7 essential essential JJ cord-015365-iqdi99pd 1966 8 nitric nitric NN cord-015365-iqdi99pd 1966 9 oxide oxide NN cord-015365-iqdi99pd 1966 10 synthase synthase NN cord-015365-iqdi99pd 1966 11 cofactor cofactor NN cord-015365-iqdi99pd 1966 12 ( ( -LRB- cord-015365-iqdi99pd 1966 13 NOS NOS NNP cord-015365-iqdi99pd 1966 14 ) ) -RRB- cord-015365-iqdi99pd 1966 15 tetrahydrobiopterin tetrahydrobiopterin NNP cord-015365-iqdi99pd 1966 16 ( ( -LRB- cord-015365-iqdi99pd 1966 17 H4B h4b NN cord-015365-iqdi99pd 1966 18 ) ) -RRB- cord-015365-iqdi99pd 1966 19 was be VBD cord-015365-iqdi99pd 1966 20 shown show VBN cord-015365-iqdi99pd 1966 21 to to TO cord-015365-iqdi99pd 1966 22 attenuate attenuate VB cord-015365-iqdi99pd 1966 23 ischemia ischemia NN cord-015365-iqdi99pd 1966 24 - - HYPH cord-015365-iqdi99pd 1966 25 reperfusion reperfusion NN cord-015365-iqdi99pd 1966 26 - - HYPH cord-015365-iqdi99pd 1966 27 injury injury NN cord-015365-iqdi99pd 1966 28 - - HYPH cord-015365-iqdi99pd 1966 29 related relate VBN cord-015365-iqdi99pd 1966 30 pancreatitis pancreatitis NN cord-015365-iqdi99pd 1966 31 in in IN cord-015365-iqdi99pd 1966 32 a a DT cord-015365-iqdi99pd 1966 33 murine murine JJ cord-015365-iqdi99pd 1966 34 pancreas pancreas NN cord-015365-iqdi99pd 1966 35 transplantation transplantation NN cord-015365-iqdi99pd 1966 36 ( ( -LRB- cord-015365-iqdi99pd 1966 37 PTX PTX NNP cord-015365-iqdi99pd 1966 38 ) ) -RRB- cord-015365-iqdi99pd 1966 39 model model NN cord-015365-iqdi99pd 1966 40 . . . cord-015365-iqdi99pd 1967 1 Since since IN cord-015365-iqdi99pd 1967 2 underlying underlie VBG cord-015365-iqdi99pd 1967 3 mechanisms mechanism NNS cord-015365-iqdi99pd 1967 4 of of IN cord-015365-iqdi99pd 1967 5 tetrahydrobiopterin tetrahydrobiopterin NN cord-015365-iqdi99pd 1967 6 - - HYPH cord-015365-iqdi99pd 1967 7 mediated mediate VBN cord-015365-iqdi99pd 1967 8 protection protection NN cord-015365-iqdi99pd 1967 9 are be VBP cord-015365-iqdi99pd 1967 10 still still RB cord-015365-iqdi99pd 1967 11 controversially controversially RB cord-015365-iqdi99pd 1967 12 discussed discuss VBN cord-015365-iqdi99pd 1967 13 , , , cord-015365-iqdi99pd 1967 14 we -PRON- PRP cord-015365-iqdi99pd 1967 15 aimed aim VBD cord-015365-iqdi99pd 1967 16 to to TO cord-015365-iqdi99pd 1967 17 investigate investigate VB cord-015365-iqdi99pd 1967 18 , , , cord-015365-iqdi99pd 1967 19 whether whether IN cord-015365-iqdi99pd 1967 20 the the DT cord-015365-iqdi99pd 1967 21 two two CD cord-015365-iqdi99pd 1967 22 constitutively constitutively RB cord-015365-iqdi99pd 1967 23 expressed express VBN cord-015365-iqdi99pd 1967 24 NOS NOS NNP cord-015365-iqdi99pd 1967 25 - - HYPH cord-015365-iqdi99pd 1967 26 isoforms isoform NNS cord-015365-iqdi99pd 1967 27 represent represent VBP cord-015365-iqdi99pd 1967 28 its -PRON- PRP$ cord-015365-iqdi99pd 1967 29 major major JJ cord-015365-iqdi99pd 1967 30 targets target NNS cord-015365-iqdi99pd 1967 31 using use VBG cord-015365-iqdi99pd 1967 32 endothelial endothelial JJ cord-015365-iqdi99pd 1967 33 ( ( -LRB- cord-015365-iqdi99pd 1967 34 eNOS-/- eNOS-/- '' cord-015365-iqdi99pd 1967 35 ) ) -RRB- cord-015365-iqdi99pd 1967 36 and and CC cord-015365-iqdi99pd 1967 37 neuronal neuronal JJ cord-015365-iqdi99pd 1967 38 NOS NOS NNP cord-015365-iqdi99pd 1967 39 ( ( -LRB- cord-015365-iqdi99pd 1967 40 nNOS-/- nNOS-/- NNP cord-015365-iqdi99pd 1967 41 ) ) -RRB- cord-015365-iqdi99pd 1967 42 knockout knockout NN cord-015365-iqdi99pd 1967 43 mice mouse NNS cord-015365-iqdi99pd 1967 44 . . . cord-015365-iqdi99pd 1968 1 Methods method NNS cord-015365-iqdi99pd 1968 2 . . . cord-015365-iqdi99pd 1969 1 In in IN cord-015365-iqdi99pd 1969 2 a a DT cord-015365-iqdi99pd 1969 3 heterotopic heterotopic NNP cord-015365-iqdi99pd 1969 4 PTX PTX NNP cord-015365-iqdi99pd 1969 5 - - HYPH cord-015365-iqdi99pd 1969 6 model model NN cord-015365-iqdi99pd 1969 7 syngeneic syngeneic NNS cord-015365-iqdi99pd 1969 8 C57BL6 c57bl6 NN cord-015365-iqdi99pd 1969 9 mice mouse NNS cord-015365-iqdi99pd 1969 10 ( ( -LRB- cord-015365-iqdi99pd 1969 11 wild wild JJ cord-015365-iqdi99pd 1969 12 - - HYPH cord-015365-iqdi99pd 1969 13 type type NN cord-015365-iqdi99pd 1969 14 , , , cord-015365-iqdi99pd 1969 15 eNOS-/-and eNOS-/-and NNP cord-015365-iqdi99pd 1969 16 nNOS-/- nNOS-/- NNP cord-015365-iqdi99pd 1969 17 ) ) -RRB- cord-015365-iqdi99pd 1969 18 were be VBD cord-015365-iqdi99pd 1969 19 used use VBN cord-015365-iqdi99pd 1969 20 as as IN cord-015365-iqdi99pd 1969 21 donorrecipient donorrecipient NN cord-015365-iqdi99pd 1969 22 pairs pair NNS cord-015365-iqdi99pd 1969 23 . . . cord-015365-iqdi99pd 1970 1 Non non JJ cord-015365-iqdi99pd 1970 2 - - JJ cord-015365-iqdi99pd 1970 3 transplanted transplanted JJ cord-015365-iqdi99pd 1970 4 animals animal NNS cord-015365-iqdi99pd 1970 5 served serve VBD cord-015365-iqdi99pd 1970 6 as as IN cord-015365-iqdi99pd 1970 7 controls control NNS cord-015365-iqdi99pd 1970 8 . . . cord-015365-iqdi99pd 1971 1 Following follow VBG cord-015365-iqdi99pd 1971 2 a a DT cord-015365-iqdi99pd 1971 3 reperfusion reperfusion NN cord-015365-iqdi99pd 1971 4 time time NN cord-015365-iqdi99pd 1971 5 of of IN cord-015365-iqdi99pd 1971 6 4 4 CD cord-015365-iqdi99pd 1971 7 h h NN cord-015365-iqdi99pd 1971 8 , , , cord-015365-iqdi99pd 1971 9 graft graft NN cord-015365-iqdi99pd 1971 10 microcirculation microcirculation NN cord-015365-iqdi99pd 1971 11 was be VBD cord-015365-iqdi99pd 1971 12 analyzed analyze VBN cord-015365-iqdi99pd 1971 13 by by IN cord-015365-iqdi99pd 1971 14 intravital intravital JJ cord-015365-iqdi99pd 1971 15 fluorescence fluorescence NN cord-015365-iqdi99pd 1971 16 microscopy microscopy NN cord-015365-iqdi99pd 1971 17 . . . cord-015365-iqdi99pd 1972 1 Parenchymal parenchymal JJ cord-015365-iqdi99pd 1972 2 damage damage NN cord-015365-iqdi99pd 1972 3 as as RB cord-015365-iqdi99pd 1972 4 well well RB cord-015365-iqdi99pd 1972 5 as as IN cord-015365-iqdi99pd 1972 6 peroxynitrite peroxynitrite NN cord-015365-iqdi99pd 1972 7 - - HYPH cord-015365-iqdi99pd 1972 8 formation formation NN cord-015365-iqdi99pd 1972 9 were be VBD cord-015365-iqdi99pd 1972 10 assessed assess VBN cord-015365-iqdi99pd 1972 11 by by IN cord-015365-iqdi99pd 1972 12 H&E H&E NNP cord-015365-iqdi99pd 1972 13 - - HYPH cord-015365-iqdi99pd 1972 14 staining stain VBG cord-015365-iqdi99pd 1972 15 and and CC cord-015365-iqdi99pd 1972 16 immunohistochemistry immunohistochemistry NN cord-015365-iqdi99pd 1972 17 . . . cord-015365-iqdi99pd 1973 1 H4B h4b NN cord-015365-iqdi99pd 1973 2 levels level NNS cord-015365-iqdi99pd 1973 3 were be VBD cord-015365-iqdi99pd 1973 4 determined determine VBN cord-015365-iqdi99pd 1973 5 by by IN cord-015365-iqdi99pd 1973 6 high high JJ cord-015365-iqdi99pd 1973 7 - - HYPH cord-015365-iqdi99pd 1973 8 performance performance NN cord-015365-iqdi99pd 1973 9 liquid liquid NN cord-015365-iqdi99pd 1973 10 chromatography chromatography NN cord-015365-iqdi99pd 1973 11 ( ( -LRB- cord-015365-iqdi99pd 1973 12 HPLC HPLC NNP cord-015365-iqdi99pd 1973 13 ) ) -RRB- cord-015365-iqdi99pd 1973 14 . . . cord-015365-iqdi99pd 1974 1 Finally finally RB cord-015365-iqdi99pd 1974 2 , , , cord-015365-iqdi99pd 1974 3 all all DT cord-015365-iqdi99pd 1974 4 groups group NNS cord-015365-iqdi99pd 1974 5 where where WRB cord-015365-iqdi99pd 1974 6 tested test VBN cord-015365-iqdi99pd 1974 7 for for IN cord-015365-iqdi99pd 1974 8 recipient recipient NN cord-015365-iqdi99pd 1974 9 survival survival NN cord-015365-iqdi99pd 1974 10 . . . cord-015365-iqdi99pd 1975 1 Results result NNS cord-015365-iqdi99pd 1975 2 . . . cord-015365-iqdi99pd 1976 1 Compared compare VBN cord-015365-iqdi99pd 1976 2 to to IN cord-015365-iqdi99pd 1976 3 non non JJ cord-015365-iqdi99pd 1976 4 - - JJ cord-015365-iqdi99pd 1976 5 transplanted transplanted JJ cord-015365-iqdi99pd 1976 6 controls control NNS cord-015365-iqdi99pd 1976 7 , , , cord-015365-iqdi99pd 1976 8 prolonged prolong VBN cord-015365-iqdi99pd 1976 9 CIT CIT NNP cord-015365-iqdi99pd 1976 10 significantly significantly RB cord-015365-iqdi99pd 1976 11 worsened worsen VBD cord-015365-iqdi99pd 1976 12 microcirculation microcirculation NN cord-015365-iqdi99pd 1976 13 in in IN cord-015365-iqdi99pd 1976 14 untreated untreated JJ cord-015365-iqdi99pd 1976 15 wildtype wildtype NN cord-015365-iqdi99pd 1976 16 and and CC cord-015365-iqdi99pd 1976 17 eNOS-/-grafts enos-/-graft NNS cord-015365-iqdi99pd 1977 1 ( ( -LRB- cord-015365-iqdi99pd 1977 2 p p NN cord-015365-iqdi99pd 1977 3 < < XX cord-015365-iqdi99pd 1977 4 0.05 0.05 CD cord-015365-iqdi99pd 1977 5 ) ) -RRB- cord-015365-iqdi99pd 1977 6 , , , cord-015365-iqdi99pd 1977 7 whereas whereas IN cord-015365-iqdi99pd 1977 8 no no DT cord-015365-iqdi99pd 1977 9 deterioration deterioration NN cord-015365-iqdi99pd 1977 10 was be VBD cord-015365-iqdi99pd 1977 11 measured measure VBN cord-015365-iqdi99pd 1977 12 in in IN cord-015365-iqdi99pd 1977 13 untreated untreated JJ cord-015365-iqdi99pd 1977 14 nNOS-/- nnos-/- NN cord-015365-iqdi99pd 1977 15 . . . cord-015365-iqdi99pd 1978 1 While while IN cord-015365-iqdi99pd 1978 2 H4B h4b NN cord-015365-iqdi99pd 1978 3 - - HYPH cord-015365-iqdi99pd 1978 4 pre pre NN cord-015365-iqdi99pd 1978 5 - - NN cord-015365-iqdi99pd 1978 6 treatment treatment NN cord-015365-iqdi99pd 1978 7 significantly significantly RB cord-015365-iqdi99pd 1978 8 restored restore VBD cord-015365-iqdi99pd 1978 9 capillary capillary JJ cord-015365-iqdi99pd 1978 10 blood blood NN cord-015365-iqdi99pd 1978 11 flow flow NN cord-015365-iqdi99pd 1978 12 in in IN cord-015365-iqdi99pd 1978 13 wild wild JJ cord-015365-iqdi99pd 1978 14 - - HYPH cord-015365-iqdi99pd 1978 15 types type NNS cord-015365-iqdi99pd 1978 16 and and CC cord-015365-iqdi99pd 1978 17 eNOS-/-(p enos-/-(p NN cord-015365-iqdi99pd 1978 18 < < XX cord-015365-iqdi99pd 1978 19 0.01 0.01 CD cord-015365-iqdi99pd 1978 20 ) ) -RRB- cord-015365-iqdi99pd 1978 21 , , , cord-015365-iqdi99pd 1978 22 no no DT cord-015365-iqdi99pd 1978 23 further further JJ cord-015365-iqdi99pd 1978 24 beneficial beneficial JJ cord-015365-iqdi99pd 1978 25 effect effect NN cord-015365-iqdi99pd 1978 26 was be VBD cord-015365-iqdi99pd 1978 27 observed observe VBN cord-015365-iqdi99pd 1978 28 in in IN cord-015365-iqdi99pd 1978 29 nNOS-/-(p nNOS-/-(p NNP cord-015365-iqdi99pd 1978 30 > > XX cord-015365-iqdi99pd 1978 31 0.05 0.05 CD cord-015365-iqdi99pd 1978 32 ) ) -RRB- cord-015365-iqdi99pd 1978 33 . . . cord-015365-iqdi99pd 1979 1 In in IN cord-015365-iqdi99pd 1979 2 contrast contrast NN cord-015365-iqdi99pd 1979 3 to to IN cord-015365-iqdi99pd 1979 4 untreated untreated JJ cord-015365-iqdi99pd 1979 5 wild wild JJ cord-015365-iqdi99pd 1979 6 - - HYPH cord-015365-iqdi99pd 1979 7 type type NN cord-015365-iqdi99pd 1979 8 and and CC cord-015365-iqdi99pd 1979 9 eNOS-/-graft enos-/-graft NN cord-015365-iqdi99pd 1979 10 , , , cord-015365-iqdi99pd 1979 11 nNOS-/-grafts nnos-/-graft NNS cord-015365-iqdi99pd 1979 12 developed develop VBD cord-015365-iqdi99pd 1979 13 minor minor JJ cord-015365-iqdi99pd 1979 14 parenchymal parenchymal NN cord-015365-iqdi99pd 1979 15 damage damage NN cord-015365-iqdi99pd 1979 16 following follow VBG cord-015365-iqdi99pd 1979 17 prolonged prolong VBN cord-015365-iqdi99pd 1979 18 CIT cit NN cord-015365-iqdi99pd 1979 19 , , , cord-015365-iqdi99pd 1979 20 which which WDT cord-015365-iqdi99pd 1979 21 could could MD cord-015365-iqdi99pd 1979 22 be be VB cord-015365-iqdi99pd 1979 23 slightly slightly RB cord-015365-iqdi99pd 1979 24 ameliorated ameliorate VBN cord-015365-iqdi99pd 1979 25 by by IN cord-015365-iqdi99pd 1979 26 tetrahydrobiopterin tetrahydrobiopterin NNP cord-015365-iqdi99pd 1979 27 pre pre VBN cord-015365-iqdi99pd 1979 28 - - NN cord-015365-iqdi99pd 1979 29 treatment treatment NN cord-015365-iqdi99pd 1979 30 . . . cord-015365-iqdi99pd 1980 1 There there EX cord-015365-iqdi99pd 1980 2 were be VBD cord-015365-iqdi99pd 1980 3 n't not RB cord-015365-iqdi99pd 1980 4 any any DT cord-015365-iqdi99pd 1980 5 significant significant JJ cord-015365-iqdi99pd 1980 6 differences difference NNS cord-015365-iqdi99pd 1980 7 between between IN cord-015365-iqdi99pd 1980 8 the the DT cord-015365-iqdi99pd 1980 9 analyzed analyze VBN cord-015365-iqdi99pd 1980 10 groups group NNS cord-015365-iqdi99pd 1980 11 regarding regard VBG cord-015365-iqdi99pd 1980 12 intragraft intragraft NNP cord-015365-iqdi99pd 1980 13 nitrotyrosine nitrotyrosine NNP cord-015365-iqdi99pd 1980 14 formation formation NN cord-015365-iqdi99pd 1980 15 . . . cord-015365-iqdi99pd 1981 1 While while IN cord-015365-iqdi99pd 1981 2 H4B h4b CD cord-015365-iqdi99pd 1981 3 pre pre JJ cord-015365-iqdi99pd 1981 4 - - JJ cord-015365-iqdi99pd 1981 5 treatment treatment JJ cord-015365-iqdi99pd 1981 6 extended extend VBN cord-015365-iqdi99pd 1981 7 survival survival NN cord-015365-iqdi99pd 1981 8 of of IN cord-015365-iqdi99pd 1981 9 all all DT cord-015365-iqdi99pd 1981 10 recipients recipient NNS cord-015365-iqdi99pd 1981 11 , , , cord-015365-iqdi99pd 1981 12 significantly significantly RB cord-015365-iqdi99pd 1981 13 prolonged prolong VBD cord-015365-iqdi99pd 1981 14 recipient recipient NN cord-015365-iqdi99pd 1981 15 survival survival NN cord-015365-iqdi99pd 1981 16 was be VBD cord-015365-iqdi99pd 1981 17 also also RB cord-015365-iqdi99pd 1981 18 achieved achieve VBN cord-015365-iqdi99pd 1981 19 if if IN cord-015365-iqdi99pd 1981 20 donors donor NNS cord-015365-iqdi99pd 1981 21 were be VBD cord-015365-iqdi99pd 1981 22 untreated untreated JJ cord-015365-iqdi99pd 1981 23 nNOS-/-(p nNOS-/-(p NNP cord-015365-iqdi99pd 1981 24 < < XX cord-015365-iqdi99pd 1981 25 0.01 0.01 CD cord-015365-iqdi99pd 1981 26 ) ) -RRB- cord-015365-iqdi99pd 1981 27 . . . cord-015365-iqdi99pd 1982 1 Conclusions conclusion NNS cord-015365-iqdi99pd 1982 2 . . . cord-015365-iqdi99pd 1983 1 These these DT cord-015365-iqdi99pd 1983 2 observations observation NNS cord-015365-iqdi99pd 1983 3 in in IN cord-015365-iqdi99pd 1983 4 pancreatic pancreatic JJ cord-015365-iqdi99pd 1983 5 grafts graft NNS cord-015365-iqdi99pd 1983 6 lacking lack VBG cord-015365-iqdi99pd 1983 7 nNOS nnos NN cord-015365-iqdi99pd 1983 8 suggest suggest VBP cord-015365-iqdi99pd 1983 9 , , , cord-015365-iqdi99pd 1983 10 that that IN cord-015365-iqdi99pd 1983 11 instead instead RB cord-015365-iqdi99pd 1983 12 of of IN cord-015365-iqdi99pd 1983 13 the the DT cord-015365-iqdi99pd 1983 14 endothelial endothelial JJ cord-015365-iqdi99pd 1983 15 isoform isoform NN cord-015365-iqdi99pd 1983 16 , , , cord-015365-iqdi99pd 1983 17 it -PRON- PRP cord-015365-iqdi99pd 1983 18 is be VBZ cord-015365-iqdi99pd 1983 19 the the DT cord-015365-iqdi99pd 1983 20 neuronal neuronal JJ cord-015365-iqdi99pd 1983 21 isoform isoform NN cord-015365-iqdi99pd 1983 22 to to TO cord-015365-iqdi99pd 1983 23 be be VB cord-015365-iqdi99pd 1983 24 crucially crucially RB cord-015365-iqdi99pd 1983 25 involved involve VBN cord-015365-iqdi99pd 1983 26 in in IN cord-015365-iqdi99pd 1983 27 the the DT cord-015365-iqdi99pd 1983 28 promotion promotion NN cord-015365-iqdi99pd 1983 29 of of IN cord-015365-iqdi99pd 1983 30 ischemia ischemia NN cord-015365-iqdi99pd 1983 31 - - HYPH cord-015365-iqdi99pd 1983 32 reperfusion reperfusion NN cord-015365-iqdi99pd 1983 33 - - HYPH cord-015365-iqdi99pd 1983 34 injury injury NN cord-015365-iqdi99pd 1983 35 in in IN cord-015365-iqdi99pd 1983 36 this this DT cord-015365-iqdi99pd 1983 37 model model NN cord-015365-iqdi99pd 1983 38 , , , cord-015365-iqdi99pd 1983 39 representing represent VBG cord-015365-iqdi99pd 1983 40 therefore therefore RB cord-015365-iqdi99pd 1983 41 the the DT cord-015365-iqdi99pd 1983 42 major major JJ cord-015365-iqdi99pd 1983 43 target target NN cord-015365-iqdi99pd 1983 44 of of IN cord-015365-iqdi99pd 1983 45 tetrahydrobiopterin tetrahydrobiopterin NN cord-015365-iqdi99pd 1983 46 mediated mediate VBD cord-015365-iqdi99pd 1983 47 protection protection NN cord-015365-iqdi99pd 1983 48 . . . cord-015365-iqdi99pd 1984 1 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 1984 2 optimieren optimieren TO cord-015365-iqdi99pd 1984 3 die die VBP cord-015365-iqdi99pd 1984 4 Organfunktion Organfunktion NNP cord-015365-iqdi99pd 1984 5 in in IN cord-015365-iqdi99pd 1984 6 einem einem NNP cord-015365-iqdi99pd 1984 7 Rattennieren Rattennieren NNP cord-015365-iqdi99pd 1984 8 - - HYPH cord-015365-iqdi99pd 1984 9 Ischämie Ischämie NNP cord-015365-iqdi99pd 1984 10 - - HYPH cord-015365-iqdi99pd 1984 11 Reperfusionsmode Reperfusionsmode NNP cord-015365-iqdi99pd 1984 12 P. P. NNP cord-015365-iqdi99pd 1984 13 Gehwolf Gehwolf NNP cord-015365-iqdi99pd 1984 14 1 1 CD cord-015365-iqdi99pd 1984 15 , , , cord-015365-iqdi99pd 1984 16 F. F. NNP cord-015365-iqdi99pd 1984 17 M. M. NNP cord-015365-iqdi99pd 1984 18 Struller Struller NNP cord-015365-iqdi99pd 1984 19 1 1 CD cord-015365-iqdi99pd 1984 20 , , , cord-015365-iqdi99pd 1984 21 A. A. NNP cord-015365-iqdi99pd 1984 22 Kostron Kostron NNP cord-015365-iqdi99pd 1984 23 1 1 CD cord-015365-iqdi99pd 1984 24 , , , cord-015365-iqdi99pd 1984 25 M. M. NNP cord-015365-iqdi99pd 1984 26 Wolzt Wolzt NNP cord-015365-iqdi99pd 1984 27 2 2 CD cord-015365-iqdi99pd 1984 28 , , , cord-015365-iqdi99pd 1984 29 F. F. NNP cord-015365-iqdi99pd 1984 30 Bach Bach NNP cord-015365-iqdi99pd 1984 31 3 3 CD cord-015365-iqdi99pd 1984 32 , , , cord-015365-iqdi99pd 1984 33 L. L. NNP cord-015365-iqdi99pd 1984 34 Otterbein Otterbein NNP cord-015365-iqdi99pd 1984 35 3 3 CD cord-015365-iqdi99pd 1984 36 , , , cord-015365-iqdi99pd 1984 37 B. B. NNP cord-015365-iqdi99pd 1984 38 Wegiel Wegiel NNP cord-015365-iqdi99pd 1984 39 3 3 CD cord-015365-iqdi99pd 1984 40 , , , cord-015365-iqdi99pd 1984 41 J. J. NNP cord-015365-iqdi99pd 1984 42 Pratschke Pratschke NNP cord-015365-iqdi99pd 1984 43 1 1 CD cord-015365-iqdi99pd 1984 44 , , , cord-015365-iqdi99pd 1984 45 R. R. NNP cord-015365-iqdi99pd 1984 46 Öllinger Öllinger NNP cord-015365-iqdi99pd 1984 47 1 1 CD cord-015365-iqdi99pd 1984 48 tion tion NN cord-015365-iqdi99pd 1984 49 , , , cord-015365-iqdi99pd 1984 50 and and CC cord-015365-iqdi99pd 1984 51 angiogenic angiogenic JJ cord-015365-iqdi99pd 1984 52 sprouting sprout VBG cord-015365-iqdi99pd 1984 53 in in IN cord-015365-iqdi99pd 1984 54 vitro vitro FW cord-015365-iqdi99pd 1984 55 , , , cord-015365-iqdi99pd 1984 56 and and CC cord-015365-iqdi99pd 1984 57 angiogenesis angiogenesis NN cord-015365-iqdi99pd 1984 58 in in IN cord-015365-iqdi99pd 1984 59 a a DT cord-015365-iqdi99pd 1984 60 chicken chicken NN cord-015365-iqdi99pd 1984 61 embryochorioallantoic embryochorioallantoic NN cord-015365-iqdi99pd 1984 62 membrane membrane NN cord-015365-iqdi99pd 1984 63 assay assay NN cord-015365-iqdi99pd 1984 64 . . . cord-015365-iqdi99pd 1985 1 5 5 LS cord-015365-iqdi99pd 1985 2 0 0 CD cord-015365-iqdi99pd 1986 1 -methoxy -methoxy NNP cord-015365-iqdi99pd 1986 2 leoligin leoligin NNP cord-015365-iqdi99pd 1986 3 was be VBD cord-015365-iqdi99pd 1986 4 consequently consequently RB cord-015365-iqdi99pd 1986 5 analyzed analyze VBN cord-015365-iqdi99pd 1986 6 in in IN cord-015365-iqdi99pd 1986 7 an an DT cord-015365-iqdi99pd 1986 8 in in IN cord-015365-iqdi99pd 1986 9 vivo vivo FW cord-015365-iqdi99pd 1986 10 rat rat NN cord-015365-iqdi99pd 1986 11 MI MI NNP cord-015365-iqdi99pd 1986 12 model model NN cord-015365-iqdi99pd 1986 13 . . . cord-015365-iqdi99pd 1987 1 The the DT cord-015365-iqdi99pd 1987 2 novel novel JJ cord-015365-iqdi99pd 1987 3 compound compound NN cord-015365-iqdi99pd 1987 4 potently potently RB cord-015365-iqdi99pd 1987 5 stimulated stimulate VBD cord-015365-iqdi99pd 1987 6 angiogenesis angiogenesis NN cord-015365-iqdi99pd 1987 7 in in IN cord-015365-iqdi99pd 1987 8 the the DT cord-015365-iqdi99pd 1987 9 peri peri JJ cord-015365-iqdi99pd 1987 10 - - HYPH cord-015365-iqdi99pd 1987 11 infarction infarction NN cord-015365-iqdi99pd 1987 12 zone zone NN cord-015365-iqdi99pd 1987 13 and and CC cord-015365-iqdi99pd 1987 14 led lead VBD cord-015365-iqdi99pd 1987 15 to to IN cord-015365-iqdi99pd 1987 16 a a DT cord-015365-iqdi99pd 1987 17 significant significant JJ cord-015365-iqdi99pd 1987 18 increase increase NN cord-015365-iqdi99pd 1987 19 in in IN cord-015365-iqdi99pd 1987 20 the the DT cord-015365-iqdi99pd 1987 21 cardiac cardiac JJ cord-015365-iqdi99pd 1987 22 ejection ejection NN cord-015365-iqdi99pd 1987 23 fraction fraction NN cord-015365-iqdi99pd 1987 24 ( ( -LRB- cord-015365-iqdi99pd 1987 25 plus plus CC cord-015365-iqdi99pd 1987 26 20 20 CD cord-015365-iqdi99pd 1987 27 % % NN cord-015365-iqdi99pd 1987 28 28 28 CD cord-015365-iqdi99pd 1987 29 days day NNS cord-015365-iqdi99pd 1987 30 after after IN cord-015365-iqdi99pd 1987 31 MI MI NNP cord-015365-iqdi99pd 1987 32 ) ) -RRB- cord-015365-iqdi99pd 1987 33 in in IN cord-015365-iqdi99pd 1987 34 animals animal NNS cord-015365-iqdi99pd 1987 35 treated treat VBN cord-015365-iqdi99pd 1987 36 with with IN cord-015365-iqdi99pd 1987 37 5 5 CD cord-015365-iqdi99pd 1987 38 0 0 CD cord-015365-iqdi99pd 1988 1 -methoxy -methoxy NNP cord-015365-iqdi99pd 1988 2 leoligin leoligin NNP cord-015365-iqdi99pd 1988 3 . . . cord-015365-iqdi99pd 1989 1 Based base VBN cord-015365-iqdi99pd 1989 2 on on IN cord-015365-iqdi99pd 1989 3 microarray microarray NN cord-015365-iqdi99pd 1989 4 analyses analysis NNS cord-015365-iqdi99pd 1989 5 followed follow VBN cord-015365-iqdi99pd 1989 6 by by IN cord-015365-iqdi99pd 1989 7 knockdown knockdown NN cord-015365-iqdi99pd 1989 8 and and CC cord-015365-iqdi99pd 1989 9 over over IN cord-015365-iqdi99pd 1989 10 - - HYPH cord-015365-iqdi99pd 1989 11 expression expression NN cord-015365-iqdi99pd 1989 12 experiments experiment NNS cord-015365-iqdi99pd 1989 13 in in IN cord-015365-iqdi99pd 1989 14 vitro vitro FW cord-015365-iqdi99pd 1989 15 Cyp26B1 Cyp26B1 NNP cord-015365-iqdi99pd 1989 16 was be VBD cord-015365-iqdi99pd 1989 17 identified identify VBN cord-015365-iqdi99pd 1989 18 as as IN cord-015365-iqdi99pd 1989 19 the the DT cord-015365-iqdi99pd 1989 20 central central JJ cord-015365-iqdi99pd 1989 21 players player NNS cord-015365-iqdi99pd 1989 22 in in IN cord-015365-iqdi99pd 1989 23 5 5 CD cord-015365-iqdi99pd 1989 24 0 0 CD cord-015365-iqdi99pd 1990 1 -methoxy -methoxy : cord-015365-iqdi99pd 1990 2 leoligin leoligin NNP cord-015365-iqdi99pd 1990 3 - - HYPH cord-015365-iqdi99pd 1990 4 induced induce VBN cord-015365-iqdi99pd 1990 5 angiogenesis angiogenesis NN cord-015365-iqdi99pd 1990 6 induction induction NN cord-015365-iqdi99pd 1990 7 . . . cord-015365-iqdi99pd 1991 1 Conclusion conclusion NN cord-015365-iqdi99pd 1991 2 . . . cord-015365-iqdi99pd 1992 1 The the DT cord-015365-iqdi99pd 1992 2 data datum NNS cord-015365-iqdi99pd 1992 3 presented present VBN cord-015365-iqdi99pd 1992 4 herein herein RB cord-015365-iqdi99pd 1992 5 indicate indicate VBP cord-015365-iqdi99pd 1992 6 that that IN cord-015365-iqdi99pd 1992 7 5 5 CD cord-015365-iqdi99pd 1992 8 0methoxy 0methoxy CD cord-015365-iqdi99pd 1992 9 leoligin leoligin NNP cord-015365-iqdi99pd 1992 10 induces induce VBZ cord-015365-iqdi99pd 1992 11 angiogenesis angiogenesis NN cord-015365-iqdi99pd 1992 12 in in IN cord-015365-iqdi99pd 1992 13 the the DT cord-015365-iqdi99pd 1992 14 peri peri NN cord-015365-iqdi99pd 1992 15 - - HYPH cord-015365-iqdi99pd 1992 16 infraction infraction NN cord-015365-iqdi99pd 1992 17 area area NN cord-015365-iqdi99pd 1992 18 after after IN cord-015365-iqdi99pd 1992 19 MI MI NNP cord-015365-iqdi99pd 1992 20 via via IN cord-015365-iqdi99pd 1992 21 upregulation upregulation NN cord-015365-iqdi99pd 1992 22 of of IN cord-015365-iqdi99pd 1992 23 Cyp26B1 Cyp26B1 NNP cord-015365-iqdi99pd 1992 24 . . . cord-015365-iqdi99pd 1993 1 5 5 LS cord-015365-iqdi99pd 1993 2 0 0 CD cord-015365-iqdi99pd 1994 1 -methoxy -methoxy . cord-015365-iqdi99pd 1995 1 leoligininduced leoligininduced NNP cord-015365-iqdi99pd 1995 2 capillarisation capillarisation NN cord-015365-iqdi99pd 1995 3 is be VBZ cord-015365-iqdi99pd 1995 4 capable capable JJ cord-015365-iqdi99pd 1995 5 of of IN cord-015365-iqdi99pd 1995 6 partially partially RB cord-015365-iqdi99pd 1995 7 restoring restore VBG cord-015365-iqdi99pd 1995 8 cardiac cardiac JJ cord-015365-iqdi99pd 1995 9 function function NN cord-015365-iqdi99pd 1995 10 after after IN cord-015365-iqdi99pd 1995 11 MI MI NNP cord-015365-iqdi99pd 1995 12 . . . cord-015365-iqdi99pd 1996 1 Therefore therefore RB cord-015365-iqdi99pd 1996 2 this this DT cord-015365-iqdi99pd 1996 3 novel novel JJ cord-015365-iqdi99pd 1996 4 compound compound NN cord-015365-iqdi99pd 1996 5 could could MD cord-015365-iqdi99pd 1996 6 be be VB cord-015365-iqdi99pd 1996 7 able able JJ cord-015365-iqdi99pd 1996 8 to to TO cord-015365-iqdi99pd 1996 9 positively positively RB cord-015365-iqdi99pd 1996 10 influence influence VB cord-015365-iqdi99pd 1996 11 post post NN cord-015365-iqdi99pd 1996 12 MI MI NNP cord-015365-iqdi99pd 1996 13 myocardial myocardial JJ cord-015365-iqdi99pd 1996 14 remodeling remodeling NN cord-015365-iqdi99pd 1996 15 and and CC cord-015365-iqdi99pd 1996 16 even even RB cord-015365-iqdi99pd 1996 17 induce induce VB cord-015365-iqdi99pd 1996 18 myocardial myocardial JJ cord-015365-iqdi99pd 1996 19 recovery recovery NN cord-015365-iqdi99pd 1996 20 . . . cord-015365-iqdi99pd 1997 1 This this DT cord-015365-iqdi99pd 1997 2 or or CC cord-015365-iqdi99pd 1997 3 other other JJ cord-015365-iqdi99pd 1997 4 pharmacological pharmacological JJ cord-015365-iqdi99pd 1997 5 strategies strategy NNS cord-015365-iqdi99pd 1997 6 to to TO cord-015365-iqdi99pd 1997 7 induce induce VB cord-015365-iqdi99pd 1997 8 neoangiogenesis neoangiogenesis NNP cord-015365-iqdi99pd 1997 9 could could MD cord-015365-iqdi99pd 1997 10 preserve preserve VB cord-015365-iqdi99pd 1997 11 organ organ NN cord-015365-iqdi99pd 1997 12 function function NN cord-015365-iqdi99pd 1997 13 and and CC cord-015365-iqdi99pd 1997 14 avoid avoid VB cord-015365-iqdi99pd 1997 15 several several JJ cord-015365-iqdi99pd 1997 16 patients patient NNS cord-015365-iqdi99pd 1997 17 ending end VBG cord-015365-iqdi99pd 1997 18 on on IN cord-015365-iqdi99pd 1997 19 the the DT cord-015365-iqdi99pd 1997 20 waiting waiting NN cord-015365-iqdi99pd 1997 21 list list NN cord-015365-iqdi99pd 1997 22 for for IN cord-015365-iqdi99pd 1997 23 cardiac cardiac JJ cord-015365-iqdi99pd 1997 24 transplantation transplantation NN cord-015365-iqdi99pd 1997 25 . . . cord-015365-iqdi99pd 1998 1 Background background NN cord-015365-iqdi99pd 1998 2 . . . cord-015365-iqdi99pd 1999 1 A a DT cord-015365-iqdi99pd 1999 2 major major JJ cord-015365-iqdi99pd 1999 3 reason reason NN cord-015365-iqdi99pd 1999 4 of of IN cord-015365-iqdi99pd 1999 5 vein vein NN cord-015365-iqdi99pd 1999 6 graft graft NN cord-015365-iqdi99pd 1999 7 failure failure NN cord-015365-iqdi99pd 1999 8 after after IN cord-015365-iqdi99pd 1999 9 coronary coronary JJ cord-015365-iqdi99pd 1999 10 artery artery NN cord-015365-iqdi99pd 1999 11 bypass bypass NN cord-015365-iqdi99pd 1999 12 grafting grafting NN cord-015365-iqdi99pd 1999 13 is be VBZ cord-015365-iqdi99pd 1999 14 neointimal neointimal JJ cord-015365-iqdi99pd 1999 15 hyperplasia hyperplasia NN cord-015365-iqdi99pd 1999 16 . . . cord-015365-iqdi99pd 2000 1 Several several JJ cord-015365-iqdi99pd 2000 2 clinical clinical JJ cord-015365-iqdi99pd 2000 3 studies study NNS cord-015365-iqdi99pd 2000 4 revealed reveal VBD cord-015365-iqdi99pd 2000 5 that that IN cord-015365-iqdi99pd 2000 6 the the DT cord-015365-iqdi99pd 2000 7 patency patency NN cord-015365-iqdi99pd 2000 8 rates rate NNS cord-015365-iqdi99pd 2000 9 of of IN cord-015365-iqdi99pd 2000 10 arterial arterial JJ cord-015365-iqdi99pd 2000 11 conduits conduit NNS cord-015365-iqdi99pd 2000 12 are be VBP cord-015365-iqdi99pd 2000 13 better well JJR cord-015365-iqdi99pd 2000 14 than than IN cord-015365-iqdi99pd 2000 15 those those DT cord-015365-iqdi99pd 2000 16 of of IN cord-015365-iqdi99pd 2000 17 venous venous JJ cord-015365-iqdi99pd 2000 18 conduits conduit NNS cord-015365-iqdi99pd 2000 19 . . . cord-015365-iqdi99pd 2001 1 In in IN cord-015365-iqdi99pd 2001 2 the the DT cord-015365-iqdi99pd 2001 3 current current JJ cord-015365-iqdi99pd 2001 4 study study NN cord-015365-iqdi99pd 2001 5 , , , cord-015365-iqdi99pd 2001 6 we -PRON- PRP cord-015365-iqdi99pd 2001 7 aimed aim VBD cord-015365-iqdi99pd 2001 8 to to TO cord-015365-iqdi99pd 2001 9 improve improve VB cord-015365-iqdi99pd 2001 10 the the DT cord-015365-iqdi99pd 2001 11 patency patency NN cord-015365-iqdi99pd 2001 12 rate rate NN cord-015365-iqdi99pd 2001 13 of of IN cord-015365-iqdi99pd 2001 14 experimental experimental JJ cord-015365-iqdi99pd 2001 15 vein vein NN cord-015365-iqdi99pd 2001 16 grafts graft NNS cord-015365-iqdi99pd 2001 17 by by IN cord-015365-iqdi99pd 2001 18 induction induction NN cord-015365-iqdi99pd 2001 19 of of IN cord-015365-iqdi99pd 2001 20 graft graft NN cord-015365-iqdi99pd 2001 21 arterialisation arterialisation NN cord-015365-iqdi99pd 2001 22 by by IN cord-015365-iqdi99pd 2001 23 transplantation transplantation NN cord-015365-iqdi99pd 2001 24 of of IN cord-015365-iqdi99pd 2001 25 homologous homologous JJ cord-015365-iqdi99pd 2001 26 skeletal skeletal JJ cord-015365-iqdi99pd 2001 27 myoblasts myoblast NNS cord-015365-iqdi99pd 2001 28 . . . cord-015365-iqdi99pd 2002 1 Methods method NNS cord-015365-iqdi99pd 2002 2 . . . cord-015365-iqdi99pd 2003 1 For for IN cord-015365-iqdi99pd 2003 2 the the DT cord-015365-iqdi99pd 2003 3 experiments experiment NNS cord-015365-iqdi99pd 2003 4 we -PRON- PRP cord-015365-iqdi99pd 2003 5 isolated isolate VBD cord-015365-iqdi99pd 2003 6 skeletal skeletal JJ cord-015365-iqdi99pd 2003 7 myoblasts myoblast NNS cord-015365-iqdi99pd 2003 8 from from IN cord-015365-iqdi99pd 2003 9 C57 C57 NNP cord-015365-iqdi99pd 2003 10 / / SYM cord-015365-iqdi99pd 2003 11 Bl6 Bl6 NNP cord-015365-iqdi99pd 2003 12 mice mouse NNS cord-015365-iqdi99pd 2003 13 . . . cord-015365-iqdi99pd 2004 1 Syngenic Syngenic NNP cord-015365-iqdi99pd 2004 2 C57 C57 NNP cord-015365-iqdi99pd 2004 3 / / SYM cord-015365-iqdi99pd 2004 4 Bl6 bl6 NN cord-015365-iqdi99pd 2004 5 mice mouse NNS cord-015365-iqdi99pd 2004 6 underwent undergo VBD cord-015365-iqdi99pd 2004 7 interposition interposition NN cord-015365-iqdi99pd 2004 8 of of IN cord-015365-iqdi99pd 2004 9 the the DT cord-015365-iqdi99pd 2004 10 vena vena NNP cord-015365-iqdi99pd 2004 11 cava cava NNP cord-015365-iqdi99pd 2004 12 inferior inferior JJ cord-015365-iqdi99pd 2004 13 from from IN cord-015365-iqdi99pd 2004 14 donor donor NN cord-015365-iqdi99pd 2004 15 mice mouse NNS cord-015365-iqdi99pd 2004 16 into into IN cord-015365-iqdi99pd 2004 17 the the DT cord-015365-iqdi99pd 2004 18 common common JJ cord-015365-iqdi99pd 2004 19 carotid carotid JJ cord-015365-iqdi99pd 2004 20 artery artery NN cord-015365-iqdi99pd 2004 21 of of IN cord-015365-iqdi99pd 2004 22 recipient recipient NN cord-015365-iqdi99pd 2004 23 mice mouse NNS cord-015365-iqdi99pd 2004 24 . . . cord-015365-iqdi99pd 2005 1 We -PRON- PRP cord-015365-iqdi99pd 2005 2 used use VBD cord-015365-iqdi99pd 2005 3 2 2 CD cord-015365-iqdi99pd 2005 4 experimental experimental JJ cord-015365-iqdi99pd 2005 5 groups group NNS cord-015365-iqdi99pd 2005 6 : : : cord-015365-iqdi99pd 2005 7 one one CD cord-015365-iqdi99pd 2005 8 control control NN cord-015365-iqdi99pd 2005 9 group group NN cord-015365-iqdi99pd 2005 10 , , , cord-015365-iqdi99pd 2005 11 where where WRB cord-015365-iqdi99pd 2005 12 we -PRON- PRP cord-015365-iqdi99pd 2005 13 applied apply VBD cord-015365-iqdi99pd 2005 14 only only RB cord-015365-iqdi99pd 2005 15 the the DT cord-015365-iqdi99pd 2005 16 control control NN cord-015365-iqdi99pd 2005 17 medium medium NN cord-015365-iqdi99pd 2005 18 without without IN cord-015365-iqdi99pd 2005 19 any any DT cord-015365-iqdi99pd 2005 20 cells cell NNS cord-015365-iqdi99pd 2005 21 on on IN cord-015365-iqdi99pd 2005 22 the the DT cord-015365-iqdi99pd 2005 23 vein vein NN cord-015365-iqdi99pd 2005 24 grafts graft NNS cord-015365-iqdi99pd 2005 25 and and CC cord-015365-iqdi99pd 2005 26 a a DT cord-015365-iqdi99pd 2005 27 treatment treatment NN cord-015365-iqdi99pd 2005 28 group group NN cord-015365-iqdi99pd 2005 29 where where WRB cord-015365-iqdi99pd 2005 30 we -PRON- PRP cord-015365-iqdi99pd 2005 31 applied apply VBD cord-015365-iqdi99pd 2005 32 skeletal skeletal JJ cord-015365-iqdi99pd 2005 33 myoblast myoblast NN cord-015365-iqdi99pd 2005 34 periadventially periadventially RB cord-015365-iqdi99pd 2005 35 on on IN cord-015365-iqdi99pd 2005 36 the the DT cord-015365-iqdi99pd 2005 37 grafts graft NNS cord-015365-iqdi99pd 2005 38 . . . cord-015365-iqdi99pd 2006 1 After after IN cord-015365-iqdi99pd 2006 2 4 4 CD cord-015365-iqdi99pd 2006 3 weeks week NNS cord-015365-iqdi99pd 2006 4 of of IN cord-015365-iqdi99pd 2006 5 follow follow VB cord-015365-iqdi99pd 2006 6 up up RP cord-015365-iqdi99pd 2006 7 veins vein NNS cord-015365-iqdi99pd 2006 8 were be VBD cord-015365-iqdi99pd 2006 9 harvested harvest VBN cord-015365-iqdi99pd 2006 10 , , , cord-015365-iqdi99pd 2006 11 embedded embed VBN cord-015365-iqdi99pd 2006 12 in in IN cord-015365-iqdi99pd 2006 13 paraffin paraffin NN cord-015365-iqdi99pd 2006 14 and and CC cord-015365-iqdi99pd 2006 15 underwent undergo VBD cord-015365-iqdi99pd 2006 16 histological histological JJ cord-015365-iqdi99pd 2006 17 evaluation evaluation NN cord-015365-iqdi99pd 2006 18 . . . cord-015365-iqdi99pd 2007 1 Results result NNS cord-015365-iqdi99pd 2007 2 . . . cord-015365-iqdi99pd 2008 1 4 4 CD cord-015365-iqdi99pd 2008 2 weeks week NNS cord-015365-iqdi99pd 2008 3 after after IN cord-015365-iqdi99pd 2008 4 surgery surgery NN cord-015365-iqdi99pd 2008 5 the the DT cord-015365-iqdi99pd 2008 6 neointimal neointimal JJ cord-015365-iqdi99pd 2008 7 thickness thickness NN cord-015365-iqdi99pd 2008 8 in in IN cord-015365-iqdi99pd 2008 9 the the DT cord-015365-iqdi99pd 2008 10 control control NN cord-015365-iqdi99pd 2008 11 group group NN cord-015365-iqdi99pd 2008 12 was be VBD cord-015365-iqdi99pd 2008 13 56 56 CD cord-015365-iqdi99pd 2008 14 mm mm NN cord-015365-iqdi99pd 2008 15 ( ( -LRB- cord-015365-iqdi99pd 2008 16 15 15 CD cord-015365-iqdi99pd 2008 17 - - SYM cord-015365-iqdi99pd 2008 18 60 60 CD cord-015365-iqdi99pd 2008 19 ) ) -RRB- cord-015365-iqdi99pd 2008 20 , , , cord-015365-iqdi99pd 2008 21 whereas whereas IN cord-015365-iqdi99pd 2008 22 in in IN cord-015365-iqdi99pd 2008 23 the the DT cord-015365-iqdi99pd 2008 24 treatment treatment NN cord-015365-iqdi99pd 2008 25 group group NN cord-015365-iqdi99pd 2008 26 we -PRON- PRP cord-015365-iqdi99pd 2008 27 found find VBD cord-015365-iqdi99pd 2008 28 neointimal neointimal JJ cord-015365-iqdi99pd 2008 29 thickness thickness NN cord-015365-iqdi99pd 2008 30 levels level NNS cord-015365-iqdi99pd 2008 31 of of IN cord-015365-iqdi99pd 2008 32 183 183 CD cord-015365-iqdi99pd 2008 33 mm mm NN cord-015365-iqdi99pd 2008 34 ( ( -LRB- cord-015365-iqdi99pd 2008 35 152 152 CD cord-015365-iqdi99pd 2008 36 - - SYM cord-015365-iqdi99pd 2008 37 204 204 CD cord-015365-iqdi99pd 2008 38 ) ) -RRB- cord-015365-iqdi99pd 2009 1 ( ( -LRB- cord-015365-iqdi99pd 2009 2 p p NN cord-015365-iqdi99pd 2009 3 < < XX cord-015365-iqdi99pd 2009 4 0.001 0.001 CD cord-015365-iqdi99pd 2009 5 ) ) -RRB- cord-015365-iqdi99pd 2009 6 . . . cord-015365-iqdi99pd 2010 1 Apart apart RB cord-015365-iqdi99pd 2010 2 from from IN cord-015365-iqdi99pd 2010 3 that that DT cord-015365-iqdi99pd 2010 4 we -PRON- PRP cord-015365-iqdi99pd 2010 5 could could MD cord-015365-iqdi99pd 2010 6 show show VB cord-015365-iqdi99pd 2010 7 that that IN cord-015365-iqdi99pd 2010 8 cells cell NNS cord-015365-iqdi99pd 2010 9 remain remain VBP cord-015365-iqdi99pd 2010 10 on on IN cord-015365-iqdi99pd 2010 11 the the DT cord-015365-iqdi99pd 2010 12 outside outside NN cord-015365-iqdi99pd 2010 13 of of IN cord-015365-iqdi99pd 2010 14 the the DT cord-015365-iqdi99pd 2010 15 vein vein NN cord-015365-iqdi99pd 2010 16 wall wall NN cord-015365-iqdi99pd 2010 17 even even RB cord-015365-iqdi99pd 2010 18 after after IN cord-015365-iqdi99pd 2010 19 4 4 CD cord-015365-iqdi99pd 2010 20 weeks week NNS cord-015365-iqdi99pd 2010 21 . . . cord-015365-iqdi99pd 2011 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2011 2 . . . cord-015365-iqdi99pd 2012 1 Application application NN cord-015365-iqdi99pd 2012 2 of of IN cord-015365-iqdi99pd 2012 3 skeletal skeletal JJ cord-015365-iqdi99pd 2012 4 myoblasts myoblast NNS cord-015365-iqdi99pd 2012 5 does do VBZ cord-015365-iqdi99pd 2012 6 not not RB cord-015365-iqdi99pd 2012 7 induce induce VB cord-015365-iqdi99pd 2012 8 vascular vascular JJ cord-015365-iqdi99pd 2012 9 regeneration regeneration NN cord-015365-iqdi99pd 2012 10 after after IN cord-015365-iqdi99pd 2012 11 vein vein NN cord-015365-iqdi99pd 2012 12 graft graft NN cord-015365-iqdi99pd 2012 13 failure failure NN cord-015365-iqdi99pd 2012 14 and and CC cord-015365-iqdi99pd 2012 15 does do VBZ cord-015365-iqdi99pd 2012 16 not not RB cord-015365-iqdi99pd 2012 17 reduce reduce VB cord-015365-iqdi99pd 2012 18 neointimal neointimal JJ cord-015365-iqdi99pd 2012 19 hyperplasia hyperplasia NN cord-015365-iqdi99pd 2012 20 . . . cord-015365-iqdi99pd 2013 1 Moreover moreover RB cord-015365-iqdi99pd 2013 2 application application NN cord-015365-iqdi99pd 2013 3 of of IN cord-015365-iqdi99pd 2013 4 these these DT cord-015365-iqdi99pd 2013 5 cells cell NNS cord-015365-iqdi99pd 2013 6 leads lead VBZ cord-015365-iqdi99pd 2013 7 to to IN cord-015365-iqdi99pd 2013 8 a a DT cord-015365-iqdi99pd 2013 9 severe severe JJ cord-015365-iqdi99pd 2013 10 induction induction NN cord-015365-iqdi99pd 2013 11 of of IN cord-015365-iqdi99pd 2013 12 neointimal neointimal JJ cord-015365-iqdi99pd 2013 13 hyperplasia hyperplasia NN cord-015365-iqdi99pd 2013 14 in in IN cord-015365-iqdi99pd 2013 15 a a DT cord-015365-iqdi99pd 2013 16 murine murine JJ cord-015365-iqdi99pd 2013 17 vein vein NN cord-015365-iqdi99pd 2013 18 graft graft NN cord-015365-iqdi99pd 2013 19 model model NN cord-015365-iqdi99pd 2013 20 . . . cord-015365-iqdi99pd 2014 1 This this DT cord-015365-iqdi99pd 2014 2 might may MD cord-015365-iqdi99pd 2014 3 be be VB cord-015365-iqdi99pd 2014 4 due due JJ cord-015365-iqdi99pd 2014 5 to to IN cord-015365-iqdi99pd 2014 6 secretion secretion NN cord-015365-iqdi99pd 2014 7 of of IN cord-015365-iqdi99pd 2014 8 growth growth NN cord-015365-iqdi99pd 2014 9 factors factor NNS cord-015365-iqdi99pd 2014 10 by by IN cord-015365-iqdi99pd 2014 11 the the DT cord-015365-iqdi99pd 2014 12 cells cell NNS cord-015365-iqdi99pd 2014 13 . . . cord-015365-iqdi99pd 2015 1 Background background NN cord-015365-iqdi99pd 2015 2 . . . cord-015365-iqdi99pd 2016 1 Based base VBN cord-015365-iqdi99pd 2016 2 on on IN cord-015365-iqdi99pd 2016 3 international international JJ cord-015365-iqdi99pd 2016 4 recommendations recommendation NNS cord-015365-iqdi99pd 2016 5 combined combine VBN cord-015365-iqdi99pd 2016 6 immunosuppression immunosuppression NN cord-015365-iqdi99pd 2016 7 is be VBZ cord-015365-iqdi99pd 2016 8 used use VBN cord-015365-iqdi99pd 2016 9 after after IN cord-015365-iqdi99pd 2016 10 kidney kidney NN cord-015365-iqdi99pd 2016 11 transplantation transplantation NN cord-015365-iqdi99pd 2016 12 in in IN cord-015365-iqdi99pd 2016 13 children child NNS cord-015365-iqdi99pd 2016 14 . . . cord-015365-iqdi99pd 2017 1 A a DT cord-015365-iqdi99pd 2017 2 common common JJ cord-015365-iqdi99pd 2017 3 regimen regimen NN cord-015365-iqdi99pd 2017 4 is be VBZ cord-015365-iqdi99pd 2017 5 based base VBN cord-015365-iqdi99pd 2017 6 on on IN cord-015365-iqdi99pd 2017 7 steroids steroid NNS cord-015365-iqdi99pd 2017 8 , , , cord-015365-iqdi99pd 2017 9 mycophenolat mycophenolat NNP cord-015365-iqdi99pd 2017 10 - - HYPH cord-015365-iqdi99pd 2017 11 mofetil mofetil NNP cord-015365-iqdi99pd 2017 12 and and CC cord-015365-iqdi99pd 2017 13 cyclosporin cyclosporin VB cord-015365-iqdi99pd 2017 14 A a NN cord-015365-iqdi99pd 2017 15 with with IN cord-015365-iqdi99pd 2017 16 IL-2 IL-2 NNP cord-015365-iqdi99pd 2017 17 antagonist antagonist NN cord-015365-iqdi99pd 2017 18 induction induction NN cord-015365-iqdi99pd 2017 19 . . . cord-015365-iqdi99pd 2018 1 One one CD cord-015365-iqdi99pd 2018 2 third third NN cord-015365-iqdi99pd 2018 3 of of IN cord-015365-iqdi99pd 2018 4 the the DT cord-015365-iqdi99pd 2018 5 patients patient NNS cord-015365-iqdi99pd 2018 6 had have VBD cord-015365-iqdi99pd 2018 7 to to TO cord-015365-iqdi99pd 2018 8 be be VB cord-015365-iqdi99pd 2018 9 switched switch VBN cord-015365-iqdi99pd 2018 10 from from IN cord-015365-iqdi99pd 2018 11 cyclosporin cyclosporin NNP cord-015365-iqdi99pd 2018 12 A A NNP cord-015365-iqdi99pd 2018 13 to to IN cord-015365-iqdi99pd 2018 14 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2018 15 , , , cord-015365-iqdi99pd 2018 16 due due IN cord-015365-iqdi99pd 2018 17 to to IN cord-015365-iqdi99pd 2018 18 dermatologic dermatologic JJ cord-015365-iqdi99pd 2018 19 cosmetic cosmetic JJ cord-015365-iqdi99pd 2018 20 side side NN cord-015365-iqdi99pd 2018 21 effects effect NNS cord-015365-iqdi99pd 2018 22 . . . cord-015365-iqdi99pd 2019 1 Thus thus RB cord-015365-iqdi99pd 2019 2 , , , cord-015365-iqdi99pd 2019 3 TABIC TABIC NNP cord-015365-iqdi99pd 2019 4 was be VBD cord-015365-iqdi99pd 2019 5 established establish VBN cord-015365-iqdi99pd 2019 6 as as IN cord-015365-iqdi99pd 2019 7 a a DT cord-015365-iqdi99pd 2019 8 novel novel JJ cord-015365-iqdi99pd 2019 9 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 2019 10 regimen regimen NN cord-015365-iqdi99pd 2019 11 . . . cord-015365-iqdi99pd 2020 1 Aim aim VB cord-015365-iqdi99pd 2020 2 of of IN cord-015365-iqdi99pd 2020 3 the the DT cord-015365-iqdi99pd 2020 4 present present JJ cord-015365-iqdi99pd 2020 5 registry registry NN cord-015365-iqdi99pd 2020 6 is be VBZ cord-015365-iqdi99pd 2020 7 to to TO cord-015365-iqdi99pd 2020 8 perform perform VB cord-015365-iqdi99pd 2020 9 quality quality NN cord-015365-iqdi99pd 2020 10 assurance assurance NN cord-015365-iqdi99pd 2020 11 and and CC cord-015365-iqdi99pd 2020 12 to to TO cord-015365-iqdi99pd 2020 13 evaluate evaluate VB cord-015365-iqdi99pd 2020 14 a a DT cord-015365-iqdi99pd 2020 15 risk risk NN cord-015365-iqdi99pd 2020 16 / / SYM cord-015365-iqdi99pd 2020 17 benefit benefit NN cord-015365-iqdi99pd 2020 18 analysis analysis NN cord-015365-iqdi99pd 2020 19 of of IN cord-015365-iqdi99pd 2020 20 the the DT cord-015365-iqdi99pd 2020 21 TABIC TABIC NNP cord-015365-iqdi99pd 2020 22 - - HYPH cord-015365-iqdi99pd 2020 23 regimen regimen NN cord-015365-iqdi99pd 2020 24 compared compare VBN cord-015365-iqdi99pd 2020 25 to to IN cord-015365-iqdi99pd 2020 26 previous previous JJ cord-015365-iqdi99pd 2020 27 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 2020 28 regimens regimen NNS cord-015365-iqdi99pd 2020 29 in in IN cord-015365-iqdi99pd 2020 30 children child NNS cord-015365-iqdi99pd 2020 31 undergoing undergo VBG cord-015365-iqdi99pd 2020 32 kidney kidney NN cord-015365-iqdi99pd 2020 33 transplantation transplantation NN cord-015365-iqdi99pd 2020 34 at at IN cord-015365-iqdi99pd 2020 35 our -PRON- PRP$ cord-015365-iqdi99pd 2020 36 center center NN cord-015365-iqdi99pd 2020 37 . . . cord-015365-iqdi99pd 2021 1 Methods method NNS cord-015365-iqdi99pd 2021 2 . . . cord-015365-iqdi99pd 2022 1 In in IN cord-015365-iqdi99pd 2022 2 this this DT cord-015365-iqdi99pd 2022 3 observational observational JJ cord-015365-iqdi99pd 2022 4 single single JJ cord-015365-iqdi99pd 2022 5 - - HYPH cord-015365-iqdi99pd 2022 6 center center NN cord-015365-iqdi99pd 2022 7 study study NN cord-015365-iqdi99pd 2022 8 , , , cord-015365-iqdi99pd 2022 9 32 32 CD cord-015365-iqdi99pd 2022 10 consecutive consecutive JJ cord-015365-iqdi99pd 2022 11 patients patient NNS cord-015365-iqdi99pd 2022 12 undergoing undergo VBG cord-015365-iqdi99pd 2022 13 kidney kidney NN cord-015365-iqdi99pd 2022 14 transplantation transplantation NN cord-015365-iqdi99pd 2022 15 between between IN cord-015365-iqdi99pd 2022 16 December December NNP cord-015365-iqdi99pd 2022 17 2005 2005 CD cord-015365-iqdi99pd 2022 18 and and CC cord-015365-iqdi99pd 2022 19 October October NNP cord-015365-iqdi99pd 2022 20 2011 2011 CD cord-015365-iqdi99pd 2022 21 at at IN cord-015365-iqdi99pd 2022 22 our -PRON- PRP$ cord-015365-iqdi99pd 2022 23 center center NN cord-015365-iqdi99pd 2022 24 , , , cord-015365-iqdi99pd 2022 25 were be VBD cord-015365-iqdi99pd 2022 26 enrolled enrol VBN cord-015365-iqdi99pd 2022 27 . . . cord-015365-iqdi99pd 2023 1 Patients patient NNS cord-015365-iqdi99pd 2023 2 who who WP cord-015365-iqdi99pd 2023 3 were be VBD cord-015365-iqdi99pd 2023 4 not not RB cord-015365-iqdi99pd 2023 5 treated treat VBN cord-015365-iqdi99pd 2023 6 according accord VBG cord-015365-iqdi99pd 2023 7 to to IN cord-015365-iqdi99pd 2023 8 the the DT cord-015365-iqdi99pd 2023 9 TABIC TABIC NNP cord-015365-iqdi99pd 2023 10 - - HYPH cord-015365-iqdi99pd 2023 11 scheme scheme NN cord-015365-iqdi99pd 2023 12 served serve VBD cord-015365-iqdi99pd 2023 13 as as IN cord-015365-iqdi99pd 2023 14 a a DT cord-015365-iqdi99pd 2023 15 historic historic JJ cord-015365-iqdi99pd 2023 16 control control NN cord-015365-iqdi99pd 2023 17 . . . cord-015365-iqdi99pd 2024 1 The the DT cord-015365-iqdi99pd 2024 2 end end NN cord-015365-iqdi99pd 2024 3 - - HYPH cord-015365-iqdi99pd 2024 4 point point NN cord-015365-iqdi99pd 2024 5 was be VBD cord-015365-iqdi99pd 2024 6 a a DT cord-015365-iqdi99pd 2024 7 combination combination NN cord-015365-iqdi99pd 2024 8 of of IN cord-015365-iqdi99pd 2024 9 death death NN cord-015365-iqdi99pd 2024 10 and and CC cord-015365-iqdi99pd 2024 11 graft graft NN cord-015365-iqdi99pd 2024 12 loss loss NN cord-015365-iqdi99pd 2024 13 . . . cord-015365-iqdi99pd 2025 1 Results result NNS cord-015365-iqdi99pd 2025 2 . . . cord-015365-iqdi99pd 2026 1 5 5 CD cord-015365-iqdi99pd 2026 2 patients patient NNS cord-015365-iqdi99pd 2026 3 ( ( -LRB- cord-015365-iqdi99pd 2026 4 16 16 CD cord-015365-iqdi99pd 2026 5 % % NN cord-015365-iqdi99pd 2026 6 ) ) -RRB- cord-015365-iqdi99pd 2026 7 had have VBD cord-015365-iqdi99pd 2026 8 to to TO cord-015365-iqdi99pd 2026 9 be be VB cord-015365-iqdi99pd 2026 10 switched switch VBN cord-015365-iqdi99pd 2026 11 from from IN cord-015365-iqdi99pd 2026 12 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2026 13 to to IN cord-015365-iqdi99pd 2026 14 rapamycin rapamycin NNS cord-015365-iqdi99pd 2026 15 due due IN cord-015365-iqdi99pd 2026 16 to to IN cord-015365-iqdi99pd 2026 17 side side JJ cord-015365-iqdi99pd 2026 18 effects effect NNS cord-015365-iqdi99pd 2026 19 . . . cord-015365-iqdi99pd 2027 1 Furthermore furthermore RB cord-015365-iqdi99pd 2027 2 , , , cord-015365-iqdi99pd 2027 3 5 5 CD cord-015365-iqdi99pd 2027 4 patients patient NNS cord-015365-iqdi99pd 2027 5 ( ( -LRB- cord-015365-iqdi99pd 2027 6 16 16 CD cord-015365-iqdi99pd 2027 7 % % NN cord-015365-iqdi99pd 2027 8 ) ) -RRB- cord-015365-iqdi99pd 2027 9 suffered suffer VBD cord-015365-iqdi99pd 2027 10 from from IN cord-015365-iqdi99pd 2027 11 acute acute JJ cord-015365-iqdi99pd 2027 12 rejection rejection NN cord-015365-iqdi99pd 2027 13 , , , cord-015365-iqdi99pd 2027 14 but but CC cord-015365-iqdi99pd 2027 15 no no DT cord-015365-iqdi99pd 2027 16 graft graft NN cord-015365-iqdi99pd 2027 17 loss loss NN cord-015365-iqdi99pd 2027 18 was be VBD cord-015365-iqdi99pd 2027 19 observed observe VBN cord-015365-iqdi99pd 2027 20 . . . cord-015365-iqdi99pd 2028 1 Within within IN cord-015365-iqdi99pd 2028 2 follow follow NN cord-015365-iqdi99pd 2028 3 - - HYPH cord-015365-iqdi99pd 2028 4 up up NN cord-015365-iqdi99pd 2028 5 , , , cord-015365-iqdi99pd 2028 6 no no DT cord-015365-iqdi99pd 2028 7 patient patient NN cord-015365-iqdi99pd 2028 8 reached reach VBD cord-015365-iqdi99pd 2028 9 the the DT cord-015365-iqdi99pd 2028 10 combined combined JJ cord-015365-iqdi99pd 2028 11 end end NN cord-015365-iqdi99pd 2028 12 - - HYPH cord-015365-iqdi99pd 2028 13 point point NN cord-015365-iqdi99pd 2028 14 ( ( -LRB- cord-015365-iqdi99pd 2028 15 100 100 CD cord-015365-iqdi99pd 2028 16 % % NN cord-015365-iqdi99pd 2028 17 kidney kidney NN cord-015365-iqdi99pd 2028 18 transplant transplant NN cord-015365-iqdi99pd 2028 19 as as RB cord-015365-iqdi99pd 2028 20 well well RB cord-015365-iqdi99pd 2028 21 as as IN cord-015365-iqdi99pd 2028 22 100 100 CD cord-015365-iqdi99pd 2028 23 % % NN cord-015365-iqdi99pd 2028 24 patients patient NNS cord-015365-iqdi99pd 2028 25 survival survival NN cord-015365-iqdi99pd 2028 26 ) ) -RRB- cord-015365-iqdi99pd 2028 27 . . . cord-015365-iqdi99pd 2029 1 A a DT cord-015365-iqdi99pd 2029 2 Kaplan Kaplan NNP cord-015365-iqdi99pd 2029 3 - - HYPH cord-015365-iqdi99pd 2029 4 Meier Meier NNP cord-015365-iqdi99pd 2029 5 - - HYPH cord-015365-iqdi99pd 2029 6 analysis analysis NN cord-015365-iqdi99pd 2029 7 revealed reveal VBD cord-015365-iqdi99pd 2029 8 a a DT cord-015365-iqdi99pd 2029 9 significantly significantly RB cord-015365-iqdi99pd 2029 10 better well JJR cord-015365-iqdi99pd 2029 11 outcome outcome NN cord-015365-iqdi99pd 2029 12 for for IN cord-015365-iqdi99pd 2029 13 patients patient NNS cord-015365-iqdi99pd 2029 14 treated treat VBN cord-015365-iqdi99pd 2029 15 with with IN cord-015365-iqdi99pd 2029 16 the the DT cord-015365-iqdi99pd 2029 17 TABIC TABIC NNP cord-015365-iqdi99pd 2029 18 - - HYPH cord-015365-iqdi99pd 2029 19 scheme scheme NN cord-015365-iqdi99pd 2029 20 compared compare VBN cord-015365-iqdi99pd 2029 21 to to IN cord-015365-iqdi99pd 2029 22 controls control NNS cord-015365-iqdi99pd 2029 23 ( ( -LRB- cord-015365-iqdi99pd 2029 24 5 5 CD cord-015365-iqdi99pd 2029 25 years year NNS cord-015365-iqdi99pd 2029 26 event event NN cord-015365-iqdi99pd 2029 27 free free JJ cord-015365-iqdi99pd 2029 28 survival survival NN cord-015365-iqdi99pd 2029 29 , , , cord-015365-iqdi99pd 2029 30 TABIC TABIC NNP cord-015365-iqdi99pd 2029 31 vs. vs. IN cord-015365-iqdi99pd 2029 32 non non JJ cord-015365-iqdi99pd 2029 33 - - JJ cord-015365-iqdi99pd 2029 34 TABIC tabic JJ cord-015365-iqdi99pd 2029 35 : : : cord-015365-iqdi99pd 2029 36 100 100 CD cord-015365-iqdi99pd 2029 37 % % NN cord-015365-iqdi99pd 2029 38 vs. vs. IN cord-015365-iqdi99pd 2029 39 79 79 CD cord-015365-iqdi99pd 2029 40 % % NN cord-015365-iqdi99pd 2029 41 , , , cord-015365-iqdi99pd 2029 42 p p NN cord-015365-iqdi99pd 2029 43 ¼ ¼ CD cord-015365-iqdi99pd 2029 44 0.048 0.048 CD cord-015365-iqdi99pd 2029 45 ) ) -RRB- cord-015365-iqdi99pd 2029 46 . . . cord-015365-iqdi99pd 2030 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2030 2 . . . cord-015365-iqdi99pd 2031 1 Our -PRON- PRP$ cord-015365-iqdi99pd 2031 2 data datum NNS cord-015365-iqdi99pd 2031 3 show show VBP cord-015365-iqdi99pd 2031 4 that that IN cord-015365-iqdi99pd 2031 5 the the DT cord-015365-iqdi99pd 2031 6 TABIC TABIC NNP cord-015365-iqdi99pd 2031 7 - - HYPH cord-015365-iqdi99pd 2031 8 regimen regimen NN cord-015365-iqdi99pd 2031 9 is be VBZ cord-015365-iqdi99pd 2031 10 efficient efficient JJ cord-015365-iqdi99pd 2031 11 and and CC cord-015365-iqdi99pd 2031 12 safe safe JJ cord-015365-iqdi99pd 2031 13 compared compare VBN cord-015365-iqdi99pd 2031 14 to to TO cord-015365-iqdi99pd 2031 15 cyclosporin cyclosporin VB cord-015365-iqdi99pd 2031 16 A a DT cord-015365-iqdi99pd 2031 17 based base VBN cord-015365-iqdi99pd 2031 18 immunosuppression immunosuppression NN cord-015365-iqdi99pd 2031 19 . . . cord-015365-iqdi99pd 2032 1 Tacrolimus Tacrolimus NNP cord-015365-iqdi99pd 2032 2 is be VBZ cord-015365-iqdi99pd 2032 3 associated associate VBN cord-015365-iqdi99pd 2032 4 with with IN cord-015365-iqdi99pd 2032 5 a a DT cord-015365-iqdi99pd 2032 6 significantly significantly RB cord-015365-iqdi99pd 2032 7 better well JJR cord-015365-iqdi99pd 2032 8 graft graft NN cord-015365-iqdi99pd 2032 9 and and CC cord-015365-iqdi99pd 2032 10 patient patient JJ cord-015365-iqdi99pd 2032 11 survival survival NN cord-015365-iqdi99pd 2032 12 . . . cord-015365-iqdi99pd 2033 1 Therefore therefore RB cord-015365-iqdi99pd 2033 2 , , , cord-015365-iqdi99pd 2033 3 it -PRON- PRP cord-015365-iqdi99pd 2033 4 should should MD cord-015365-iqdi99pd 2033 5 be be VB cord-015365-iqdi99pd 2033 6 considered consider VBN cord-015365-iqdi99pd 2033 7 as as IN cord-015365-iqdi99pd 2033 8 standard standard JJ cord-015365-iqdi99pd 2033 9 therapy therapy NN cord-015365-iqdi99pd 2033 10 after after IN cord-015365-iqdi99pd 2033 11 kidney kidney NN cord-015365-iqdi99pd 2033 12 transplantation transplantation NN cord-015365-iqdi99pd 2033 13 in in IN cord-015365-iqdi99pd 2033 14 children child NNS cord-015365-iqdi99pd 2033 15 . . . cord-015365-iqdi99pd 2034 1 Falsely falsely RB cord-015365-iqdi99pd 2034 2 elevated elevate VBN cord-015365-iqdi99pd 2034 3 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2034 4 concentrations concentration NNS cord-015365-iqdi99pd 2034 5 in in IN cord-015365-iqdi99pd 2034 6 two two CD cord-015365-iqdi99pd 2034 7 kidney kidney NN cord-015365-iqdi99pd 2034 8 allograft allograft NN cord-015365-iqdi99pd 2034 9 recipients recipient NNS cord-015365-iqdi99pd 2034 10 using use VBG cord-015365-iqdi99pd 2034 11 the the DT cord-015365-iqdi99pd 2034 12 affinity affinity NN cord-015365-iqdi99pd 2034 13 column column NN cord-015365-iqdi99pd 2034 14 - - HYPH cord-015365-iqdi99pd 2034 15 mediated mediate VBN cord-015365-iqdi99pd 2034 16 immunoassay immunoassay NN cord-015365-iqdi99pd 2034 17 ( ( -LRB- cord-015365-iqdi99pd 2034 18 ACMIA ACMIA NNP cord-015365-iqdi99pd 2034 19 ) ) -RRB- cord-015365-iqdi99pd 2034 20 method method NN cord-015365-iqdi99pd 2034 21 : : : cord-015365-iqdi99pd 2034 22 identification identification NN cord-015365-iqdi99pd 2034 23 of of IN cord-015365-iqdi99pd 2034 24 IgG IgG NNP cord-015365-iqdi99pd 2034 25 isotype isotype JJ cord-015365-iqdi99pd 2034 26 rheumatoid rheumatoid NNP cord-015365-iqdi99pd 2034 27 factor factor NN cord-015365-iqdi99pd 2034 28 as as IN cord-015365-iqdi99pd 2034 29 causative causative JJ cord-015365-iqdi99pd 2034 30 endogenous endogenous JJ cord-015365-iqdi99pd 2034 31 antibodies antibody NNS cord-015365-iqdi99pd 2034 32 Background Background NNP cord-015365-iqdi99pd 2034 33 . . . cord-015365-iqdi99pd 2035 1 Therapeutic therapeutic JJ cord-015365-iqdi99pd 2035 2 monitoring monitoring NN cord-015365-iqdi99pd 2035 3 of of IN cord-015365-iqdi99pd 2035 4 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2035 5 is be VBZ cord-015365-iqdi99pd 2035 6 currently currently RB cord-015365-iqdi99pd 2035 7 performed perform VBN cord-015365-iqdi99pd 2035 8 employing employ VBG cord-015365-iqdi99pd 2035 9 ACMIA ACMIA NNP cord-015365-iqdi99pd 2035 10 in in IN cord-015365-iqdi99pd 2035 11 several several JJ cord-015365-iqdi99pd 2035 12 transplant transplant NN cord-015365-iqdi99pd 2035 13 centers center NNS cord-015365-iqdi99pd 2035 14 . . . cord-015365-iqdi99pd 2036 1 Here here RB cord-015365-iqdi99pd 2036 2 we -PRON- PRP cord-015365-iqdi99pd 2036 3 report report VBP cord-015365-iqdi99pd 2036 4 on on IN cord-015365-iqdi99pd 2036 5 two two CD cord-015365-iqdi99pd 2036 6 renal renal JJ cord-015365-iqdi99pd 2036 7 transplant transplant NN cord-015365-iqdi99pd 2036 8 patients patient NNS cord-015365-iqdi99pd 2036 9 displaying display VBG cord-015365-iqdi99pd 2036 10 excessive excessive JJ cord-015365-iqdi99pd 2036 11 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2036 12 levels level NNS cord-015365-iqdi99pd 2036 13 either either CC cord-015365-iqdi99pd 2036 14 not not RB cord-015365-iqdi99pd 2036 15 corresponding correspond VBG cord-015365-iqdi99pd 2036 16 to to IN cord-015365-iqdi99pd 2036 17 oral oral JJ cord-015365-iqdi99pd 2036 18 drug drug NN cord-015365-iqdi99pd 2036 19 dosage dosage NN cord-015365-iqdi99pd 2036 20 or or CC cord-015365-iqdi99pd 2036 21 without without IN cord-015365-iqdi99pd 2036 22 taking take VBG cord-015365-iqdi99pd 2036 23 the the DT cord-015365-iqdi99pd 2036 24 drug drug NN cord-015365-iqdi99pd 2036 25 at at RB cord-015365-iqdi99pd 2036 26 all all RB cord-015365-iqdi99pd 2036 27 . . . cord-015365-iqdi99pd 2037 1 Various various JJ cord-015365-iqdi99pd 2037 2 antibodies antibody NNS cord-015365-iqdi99pd 2037 3 , , , cord-015365-iqdi99pd 2037 4 such such JJ cord-015365-iqdi99pd 2037 5 as as IN cord-015365-iqdi99pd 2037 6 anti anti JJ cord-015365-iqdi99pd 2037 7 ds ds NNP cord-015365-iqdi99pd 2037 8 - - HYPH cord-015365-iqdi99pd 2037 9 DNA DNA NNP cord-015365-iqdi99pd 2037 10 antibodies antibody NNS cord-015365-iqdi99pd 2037 11 or or CC cord-015365-iqdi99pd 2037 12 heterophilic heterophilic NNP cord-015365-iqdi99pd 2037 13 antibodies antibody NNS cord-015365-iqdi99pd 2037 14 , , , cord-015365-iqdi99pd 2037 15 have have VBP cord-015365-iqdi99pd 2037 16 been be VBN cord-015365-iqdi99pd 2037 17 identified identify VBN cord-015365-iqdi99pd 2037 18 in in IN cord-015365-iqdi99pd 2037 19 previous previous JJ cord-015365-iqdi99pd 2037 20 cases case NNS cord-015365-iqdi99pd 2037 21 of of IN cord-015365-iqdi99pd 2037 22 falsely falsely RB cord-015365-iqdi99pd 2037 23 elevated elevate VBN cord-015365-iqdi99pd 2037 24 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2037 25 measurements measurement NNS cord-015365-iqdi99pd 2037 26 and and CC cord-015365-iqdi99pd 2037 27 have have VBP cord-015365-iqdi99pd 2037 28 been be VBN cord-015365-iqdi99pd 2037 29 suggested suggest VBN cord-015365-iqdi99pd 2037 30 as as IN cord-015365-iqdi99pd 2037 31 a a DT cord-015365-iqdi99pd 2037 32 possible possible JJ cord-015365-iqdi99pd 2037 33 cause cause NN cord-015365-iqdi99pd 2037 34 for for IN cord-015365-iqdi99pd 2037 35 interaction interaction NN cord-015365-iqdi99pd 2037 36 with with IN cord-015365-iqdi99pd 2037 37 the the DT cord-015365-iqdi99pd 2037 38 tacrolimus tacrolimus NNP cord-015365-iqdi99pd 2037 39 assay assay NN cord-015365-iqdi99pd 2037 40 . . . cord-015365-iqdi99pd 2038 1 Methods method NNS cord-015365-iqdi99pd 2038 2 and and CC cord-015365-iqdi99pd 2038 3 Results result NNS cord-015365-iqdi99pd 2038 4 . . . cord-015365-iqdi99pd 2039 1 In in IN cord-015365-iqdi99pd 2039 2 our -PRON- PRP$ cord-015365-iqdi99pd 2039 3 observations observation NNS cord-015365-iqdi99pd 2039 4 , , , cord-015365-iqdi99pd 2039 5 both both DT cord-015365-iqdi99pd 2039 6 patients patient NNS cord-015365-iqdi99pd 2039 7 were be VBD cord-015365-iqdi99pd 2039 8 on on IN cord-015365-iqdi99pd 2039 9 a a DT cord-015365-iqdi99pd 2039 10 stable stable JJ cord-015365-iqdi99pd 2039 11 , , , cord-015365-iqdi99pd 2039 12 long long JJ cord-015365-iqdi99pd 2039 13 - - HYPH cord-015365-iqdi99pd 2039 14 term term NN cord-015365-iqdi99pd 2039 15 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2039 16 - - HYPH cord-015365-iqdi99pd 2039 17 based base VBN cord-015365-iqdi99pd 2039 18 immunosuppressive immunosuppressive JJ cord-015365-iqdi99pd 2039 19 regimen regimen NN cord-015365-iqdi99pd 2039 20 . . . cord-015365-iqdi99pd 2040 1 In in IN cord-015365-iqdi99pd 2040 2 the the DT cord-015365-iqdi99pd 2040 3 first first JJ cord-015365-iqdi99pd 2040 4 patient patient NN cord-015365-iqdi99pd 2040 5 the the DT cord-015365-iqdi99pd 2040 6 elevated elevated JJ cord-015365-iqdi99pd 2040 7 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2040 8 trough trough NN cord-015365-iqdi99pd 2040 9 levels level NNS cord-015365-iqdi99pd 2040 10 were be VBD cord-015365-iqdi99pd 2040 11 only only RB cord-015365-iqdi99pd 2040 12 observed observe VBN cord-015365-iqdi99pd 2040 13 after after IN cord-015365-iqdi99pd 2040 14 loss loss NN cord-015365-iqdi99pd 2040 15 of of IN cord-015365-iqdi99pd 2040 16 graft graft NN cord-015365-iqdi99pd 2040 17 function function NN cord-015365-iqdi99pd 2040 18 ( ( -LRB- cord-015365-iqdi99pd 2040 19 6 6 CD cord-015365-iqdi99pd 2040 20 years year NNS cord-015365-iqdi99pd 2040 21 posttransplant posttransplant NNP cord-015365-iqdi99pd 2040 22 ) ) -RRB- cord-015365-iqdi99pd 2040 23 while while IN cord-015365-iqdi99pd 2040 24 the the DT cord-015365-iqdi99pd 2040 25 patient patient NN cord-015365-iqdi99pd 2040 26 was be VBD cord-015365-iqdi99pd 2040 27 not not RB cord-015365-iqdi99pd 2040 28 longer long JJR cord-015365-iqdi99pd 2040 29 on on IN cord-015365-iqdi99pd 2040 30 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2040 31 , , , cord-015365-iqdi99pd 2040 32 as as IN cord-015365-iqdi99pd 2040 33 the the DT cord-015365-iqdi99pd 2040 34 patient patient NN cord-015365-iqdi99pd 2040 35 was be VBD cord-015365-iqdi99pd 2040 36 on on IN cord-015365-iqdi99pd 2040 37 hemodialysis hemodialysis NN cord-015365-iqdi99pd 2040 38 again again RB cord-015365-iqdi99pd 2040 39 . . . cord-015365-iqdi99pd 2041 1 The the DT cord-015365-iqdi99pd 2041 2 second second JJ cord-015365-iqdi99pd 2041 3 patient patient NN cord-015365-iqdi99pd 2041 4 currently currently RB cord-015365-iqdi99pd 2041 5 still still RB cord-015365-iqdi99pd 2041 6 has have VBZ cord-015365-iqdi99pd 2041 7 a a DT cord-015365-iqdi99pd 2041 8 functioning function VBG cord-015365-iqdi99pd 2041 9 graft graft NN cord-015365-iqdi99pd 2041 10 , , , cord-015365-iqdi99pd 2041 11 although although IN cord-015365-iqdi99pd 2041 12 he -PRON- PRP cord-015365-iqdi99pd 2041 13 is be VBZ cord-015365-iqdi99pd 2041 14 taking take VBG cord-015365-iqdi99pd 2041 15 minute minute JJ cord-015365-iqdi99pd 2041 16 amounts amount NNS cord-015365-iqdi99pd 2041 17 of of IN cord-015365-iqdi99pd 2041 18 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2041 19 . . . cord-015365-iqdi99pd 2042 1 All all DT cord-015365-iqdi99pd 2042 2 rheumatoid rheumatoid JJ cord-015365-iqdi99pd 2042 3 and and CC cord-015365-iqdi99pd 2042 4 immunologic immunologic JJ cord-015365-iqdi99pd 2042 5 tests test NNS cord-015365-iqdi99pd 2042 6 ( ( -LRB- cord-015365-iqdi99pd 2042 7 including include VBG cord-015365-iqdi99pd 2042 8 anti anti JJ cord-015365-iqdi99pd 2042 9 ds ds NNP cord-015365-iqdi99pd 2042 10 - - HYPH cord-015365-iqdi99pd 2042 11 DNA DNA NNP cord-015365-iqdi99pd 2042 12 antibodies antibody NNS cord-015365-iqdi99pd 2042 13 ) ) -RRB- cord-015365-iqdi99pd 2042 14 were be VBD cord-015365-iqdi99pd 2042 15 negative negative JJ cord-015365-iqdi99pd 2042 16 , , , cord-015365-iqdi99pd 2042 17 except except IN cord-015365-iqdi99pd 2042 18 IgG igg NN cord-015365-iqdi99pd 2042 19 isotype isotype JJ cord-015365-iqdi99pd 2042 20 rheumatoid rheumatoid NN cord-015365-iqdi99pd 2042 21 factors factor NNS cord-015365-iqdi99pd 2042 22 , , , cord-015365-iqdi99pd 2042 23 which which WDT cord-015365-iqdi99pd 2042 24 proved prove VBD cord-015365-iqdi99pd 2042 25 to to TO cord-015365-iqdi99pd 2042 26 be be VB cord-015365-iqdi99pd 2042 27 highly highly RB cord-015365-iqdi99pd 2042 28 positive positive JJ cord-015365-iqdi99pd 2042 29 in in IN cord-015365-iqdi99pd 2042 30 both both DT cord-015365-iqdi99pd 2042 31 patients patient NNS cord-015365-iqdi99pd 2042 32 . . . cord-015365-iqdi99pd 2043 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2043 2 . . . cord-015365-iqdi99pd 2044 1 Our -PRON- PRP$ cord-015365-iqdi99pd 2044 2 results result NNS cord-015365-iqdi99pd 2044 3 show show VBP cord-015365-iqdi99pd 2044 4 that that IN cord-015365-iqdi99pd 2044 5 certain certain JJ cord-015365-iqdi99pd 2044 6 patients patient NNS cord-015365-iqdi99pd 2044 7 with with IN cord-015365-iqdi99pd 2044 8 positive positive JJ cord-015365-iqdi99pd 2044 9 IgG igg NN cord-015365-iqdi99pd 2044 10 isotype isotype JJ cord-015365-iqdi99pd 2044 11 rheumatoid rheumatoid NN cord-015365-iqdi99pd 2044 12 factor factor NN cord-015365-iqdi99pd 2044 13 can can MD cord-015365-iqdi99pd 2044 14 exhibit exhibit VB cord-015365-iqdi99pd 2044 15 false false JJ cord-015365-iqdi99pd 2044 16 - - HYPH cord-015365-iqdi99pd 2044 17 positive positive JJ cord-015365-iqdi99pd 2044 18 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2044 19 trough trough NN cord-015365-iqdi99pd 2044 20 levels level NNS cord-015365-iqdi99pd 2044 21 when when WRB cord-015365-iqdi99pd 2044 22 using use VBG cord-015365-iqdi99pd 2044 23 the the DT cord-015365-iqdi99pd 2044 24 ACMIA ACMIA NNP cord-015365-iqdi99pd 2044 25 assay assay NN cord-015365-iqdi99pd 2044 26 . . . cord-015365-iqdi99pd 2045 1 It -PRON- PRP cord-015365-iqdi99pd 2045 2 can can MD cord-015365-iqdi99pd 2045 3 therefore therefore RB cord-015365-iqdi99pd 2045 4 be be VB cord-015365-iqdi99pd 2045 5 concluded conclude VBN cord-015365-iqdi99pd 2045 6 that that IN cord-015365-iqdi99pd 2045 7 abnormally abnormally RB cord-015365-iqdi99pd 2045 8 high high JJ cord-015365-iqdi99pd 2045 9 drug drug NN cord-015365-iqdi99pd 2045 10 levels level NNS cord-015365-iqdi99pd 2045 11 should should MD cord-015365-iqdi99pd 2045 12 be be VB cord-015365-iqdi99pd 2045 13 verified verify VBN cord-015365-iqdi99pd 2045 14 by by IN cord-015365-iqdi99pd 2045 15 mass mass NN cord-015365-iqdi99pd 2045 16 spectrometry spectrometry NN cord-015365-iqdi99pd 2045 17 methods method NNS cord-015365-iqdi99pd 2045 18 . . . cord-015365-iqdi99pd 2046 1 Further further JJ cord-015365-iqdi99pd 2046 2 studies study NNS cord-015365-iqdi99pd 2046 3 are be VBP cord-015365-iqdi99pd 2046 4 underway underway JJ cord-015365-iqdi99pd 2046 5 to to TO cord-015365-iqdi99pd 2046 6 determine determine VB cord-015365-iqdi99pd 2046 7 whether whether IN cord-015365-iqdi99pd 2046 8 non non JJ cord-015365-iqdi99pd 2046 9 - - JJ cord-015365-iqdi99pd 2046 10 transplanted transplanted JJ cord-015365-iqdi99pd 2046 11 patients patient NNS cord-015365-iqdi99pd 2046 12 with with IN cord-015365-iqdi99pd 2046 13 positive positive JJ cord-015365-iqdi99pd 2046 14 rheumatoid rheumatoid NN cord-015365-iqdi99pd 2046 15 factors factor NNS cord-015365-iqdi99pd 2046 16 also also RB cord-015365-iqdi99pd 2046 17 display display VBP cord-015365-iqdi99pd 2046 18 falsely falsely RB cord-015365-iqdi99pd 2046 19 elevated elevate VBN cord-015365-iqdi99pd 2046 20 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2046 21 values value NNS cord-015365-iqdi99pd 2046 22 and and CC cord-015365-iqdi99pd 2046 23 also also RB cord-015365-iqdi99pd 2046 24 if if IN cord-015365-iqdi99pd 2046 25 this this DT cord-015365-iqdi99pd 2046 26 can can MD cord-015365-iqdi99pd 2046 27 be be VB cord-015365-iqdi99pd 2046 28 suppressed suppress VBN cord-015365-iqdi99pd 2046 29 after after IN cord-015365-iqdi99pd 2046 30 preincubation preincubation NN cord-015365-iqdi99pd 2046 31 with with IN cord-015365-iqdi99pd 2046 32 immunoglobulin immunoglobulin NN cord-015365-iqdi99pd 2046 33 blocking block VBG cord-015365-iqdi99pd 2046 34 reagents reagent NNS cord-015365-iqdi99pd 2046 35 specific specific JJ cord-015365-iqdi99pd 2046 36 for for IN cord-015365-iqdi99pd 2046 37 the the DT cord-015365-iqdi99pd 2046 38 IgG IgG NNP cord-015365-iqdi99pd 2046 39 isotype isotype JJ cord-015365-iqdi99pd 2046 40 rheumatoid rheumatoid NNP cord-015365-iqdi99pd 2046 41 factor factor NN cord-015365-iqdi99pd 2046 42 . . . cord-015365-iqdi99pd 2047 1 Background background NN cord-015365-iqdi99pd 2047 2 . . . cord-015365-iqdi99pd 2048 1 The the DT cord-015365-iqdi99pd 2048 2 impact impact NN cord-015365-iqdi99pd 2048 3 of of IN cord-015365-iqdi99pd 2048 4 vesicoureteral vesicoureteral JJ cord-015365-iqdi99pd 2048 5 reflux reflux NN cord-015365-iqdi99pd 2048 6 after after IN cord-015365-iqdi99pd 2048 7 renal renal JJ cord-015365-iqdi99pd 2048 8 transplantation transplantation NN cord-015365-iqdi99pd 2048 9 has have VBZ cord-015365-iqdi99pd 2048 10 been be VBN cord-015365-iqdi99pd 2048 11 a a DT cord-015365-iqdi99pd 2048 12 matter matter NN cord-015365-iqdi99pd 2048 13 of of IN cord-015365-iqdi99pd 2048 14 debate debate NN cord-015365-iqdi99pd 2048 15 in in IN cord-015365-iqdi99pd 2048 16 the the DT cord-015365-iqdi99pd 2048 17 past past NN cord-015365-iqdi99pd 2048 18 with with IN cord-015365-iqdi99pd 2048 19 small small JJ cord-015365-iqdi99pd 2048 20 studies study NNS cord-015365-iqdi99pd 2048 21 reporting report VBG cord-015365-iqdi99pd 2048 22 controversial controversial JJ cord-015365-iqdi99pd 2048 23 results result NNS cord-015365-iqdi99pd 2048 24 . . . cord-015365-iqdi99pd 2049 1 The the DT cord-015365-iqdi99pd 2049 2 aim aim NN cord-015365-iqdi99pd 2049 3 of of IN cord-015365-iqdi99pd 2049 4 the the DT cord-015365-iqdi99pd 2049 5 present present JJ cord-015365-iqdi99pd 2049 6 study study NN cord-015365-iqdi99pd 2049 7 was be VBD cord-015365-iqdi99pd 2049 8 to to TO cord-015365-iqdi99pd 2049 9 evaluate evaluate VB cord-015365-iqdi99pd 2049 10 the the DT cord-015365-iqdi99pd 2049 11 effect effect NN cord-015365-iqdi99pd 2049 12 of of IN cord-015365-iqdi99pd 2049 13 early early JJ cord-015365-iqdi99pd 2049 14 post post JJ cord-015365-iqdi99pd 2049 15 - - NN cord-015365-iqdi99pd 2049 16 transplantation transplantation JJ cord-015365-iqdi99pd 2049 17 VUR VUR NNP cord-015365-iqdi99pd 2049 18 on on IN cord-015365-iqdi99pd 2049 19 long long JJ cord-015365-iqdi99pd 2049 20 - - HYPH cord-015365-iqdi99pd 2049 21 term term NN cord-015365-iqdi99pd 2049 22 renal renal JJ cord-015365-iqdi99pd 2049 23 allograft allograft NN cord-015365-iqdi99pd 2049 24 performance performance NN cord-015365-iqdi99pd 2049 25 , , , cord-015365-iqdi99pd 2049 26 incidences incidence NNS cord-015365-iqdi99pd 2049 27 of of IN cord-015365-iqdi99pd 2049 28 urinary urinary JJ cord-015365-iqdi99pd 2049 29 tract tract NN cord-015365-iqdi99pd 2049 30 infections infection NNS cord-015365-iqdi99pd 2049 31 ( ( -LRB- cord-015365-iqdi99pd 2049 32 UTI UTI NNP cord-015365-iqdi99pd 2049 33 ) ) -RRB- cord-015365-iqdi99pd 2049 34 , , , cord-015365-iqdi99pd 2049 35 rejection rejection NN cord-015365-iqdi99pd 2049 36 rates rate NNS cord-015365-iqdi99pd 2049 37 , , , cord-015365-iqdi99pd 2049 38 graft graft NN cord-015365-iqdi99pd 2049 39 and and CC cord-015365-iqdi99pd 2049 40 patient patient JJ cord-015365-iqdi99pd 2049 41 survival survival NN cord-015365-iqdi99pd 2049 42 in in IN cord-015365-iqdi99pd 2049 43 a a DT cord-015365-iqdi99pd 2049 44 large large JJ cord-015365-iqdi99pd 2049 45 cohort cohort NN cord-015365-iqdi99pd 2049 46 series series NN cord-015365-iqdi99pd 2049 47 . . . cord-015365-iqdi99pd 2050 1 Methods method NNS cord-015365-iqdi99pd 2050 2 . . . cord-015365-iqdi99pd 2051 1 Retrospective retrospective JJ cord-015365-iqdi99pd 2051 2 study study NN cord-015365-iqdi99pd 2051 3 of of IN cord-015365-iqdi99pd 2051 4 646 646 CD cord-015365-iqdi99pd 2051 5 consecutive consecutive JJ cord-015365-iqdi99pd 2051 6 renal renal JJ cord-015365-iqdi99pd 2051 7 transplant transplant NN cord-015365-iqdi99pd 2051 8 patients patient NNS cord-015365-iqdi99pd 2051 9 with with IN cord-015365-iqdi99pd 2051 10 routine routine JJ cord-015365-iqdi99pd 2051 11 post post JJ cord-015365-iqdi99pd 2051 12 - - JJ cord-015365-iqdi99pd 2051 13 transplantation transplantation JJ cord-015365-iqdi99pd 2051 14 vesicocystourethero vesicocystourethero NNS cord-015365-iqdi99pd 2051 15 - - HYPH cord-015365-iqdi99pd 2051 16 graphy graphy NN cord-015365-iqdi99pd 2051 17 ( ( -LRB- cord-015365-iqdi99pd 2051 18 VCUG VCUG NNP cord-015365-iqdi99pd 2051 19 ) ) -RRB- cord-015365-iqdi99pd 2051 20 . . . cord-015365-iqdi99pd 2052 1 Uretero Uretero NNP cord-015365-iqdi99pd 2052 2 - - HYPH cord-015365-iqdi99pd 2052 3 neocystostomy neocystostomy NNP cord-015365-iqdi99pd 2052 4 was be VBD cord-015365-iqdi99pd 2052 5 performed perform VBN cord-015365-iqdi99pd 2052 6 in in IN cord-015365-iqdi99pd 2052 7 an an DT cord-015365-iqdi99pd 2052 8 antirefluxive antirefluxive JJ cord-015365-iqdi99pd 2052 9 fashion fashion NN cord-015365-iqdi99pd 2052 10 using use VBG cord-015365-iqdi99pd 2052 11 extravesical extravesical NNP cord-015365-iqdi99pd 2052 12 submucosal submucosal NNP cord-015365-iqdi99pd 2052 13 tunneling tunneling NN cord-015365-iqdi99pd 2052 14 . . . cord-015365-iqdi99pd 2053 1 VCUG VCUG NNP cord-015365-iqdi99pd 2053 2 was be VBD cord-015365-iqdi99pd 2053 3 performed perform VBN cord-015365-iqdi99pd 2053 4 prior prior RB cord-015365-iqdi99pd 2053 5 to to IN cord-015365-iqdi99pd 2053 6 discharge discharge NN cord-015365-iqdi99pd 2053 7 according accord VBG cord-015365-iqdi99pd 2053 8 to to IN cord-015365-iqdi99pd 2053 9 the the DT cord-015365-iqdi99pd 2053 10 international international JJ cord-015365-iqdi99pd 2053 11 grading grading NN cord-015365-iqdi99pd 2053 12 system system NN cord-015365-iqdi99pd 2053 13 and and CC cord-015365-iqdi99pd 2053 14 reviewed review VBN cord-015365-iqdi99pd 2053 15 by by IN cord-015365-iqdi99pd 2053 16 an an DT cord-015365-iqdi99pd 2053 17 independent independent JJ cord-015365-iqdi99pd 2053 18 radiologist radiologist NN cord-015365-iqdi99pd 2053 19 and and CC cord-015365-iqdi99pd 2053 20 urologist urologist NN cord-015365-iqdi99pd 2053 21 . . . cord-015365-iqdi99pd 2054 1 Results result NNS cord-015365-iqdi99pd 2054 2 . . . cord-015365-iqdi99pd 2055 1 Overall overall RB cord-015365-iqdi99pd 2055 2 , , , cord-015365-iqdi99pd 2055 3 263 263 CD cord-015365-iqdi99pd 2055 4 of of IN cord-015365-iqdi99pd 2055 5 the the DT cord-015365-iqdi99pd 2055 6 646 646 CD cord-015365-iqdi99pd 2055 7 ( ( -LRB- cord-015365-iqdi99pd 2055 8 40.7 40.7 CD cord-015365-iqdi99pd 2055 9 % % NN cord-015365-iqdi99pd 2055 10 ) ) -RRB- cord-015365-iqdi99pd 2055 11 kidney kidney NN cord-015365-iqdi99pd 2055 12 transplant transplant NN cord-015365-iqdi99pd 2055 13 recipients recipient NNS cord-015365-iqdi99pd 2055 14 were be VBD cord-015365-iqdi99pd 2055 15 diagnosed diagnose VBN cord-015365-iqdi99pd 2055 16 with with IN cord-015365-iqdi99pd 2055 17 VUR VUR NNP cord-015365-iqdi99pd 2055 18 by by IN cord-015365-iqdi99pd 2055 19 VCUG VCUG NNP cord-015365-iqdi99pd 2055 20 at at IN cord-015365-iqdi99pd 2055 21 discharge discharge NN cord-015365-iqdi99pd 2055 22 . . . cord-015365-iqdi99pd 2056 1 Patients patient NNS cord-015365-iqdi99pd 2056 2 had have VBD cord-015365-iqdi99pd 2056 3 VUR VUR NNP cord-015365-iqdi99pd 2056 4 grade grade NN cord-015365-iqdi99pd 2056 5 I I NNP cord-015365-iqdi99pd 2056 6 , , , cord-015365-iqdi99pd 2056 7 II II NNP cord-015365-iqdi99pd 2056 8 , , , cord-015365-iqdi99pd 2056 9 III III NNP cord-015365-iqdi99pd 2056 10 and and CC cord-015365-iqdi99pd 2056 11 IV IV NNP cord-015365-iqdi99pd 2056 12 in in IN cord-015365-iqdi99pd 2056 13 7.9 7.9 CD cord-015365-iqdi99pd 2056 14 % % NN cord-015365-iqdi99pd 2056 15 , , , cord-015365-iqdi99pd 2056 16 19.8 19.8 CD cord-015365-iqdi99pd 2056 17 % % NN cord-015365-iqdi99pd 2056 18 , , , cord-015365-iqdi99pd 2056 19 10.2 10.2 CD cord-015365-iqdi99pd 2056 20 % % NN cord-015365-iqdi99pd 2056 21 , , , cord-015365-iqdi99pd 2056 22 and and CC cord-015365-iqdi99pd 2056 23 2.8 2.8 CD cord-015365-iqdi99pd 2056 24 % % NN cord-015365-iqdi99pd 2056 25 , , , cord-015365-iqdi99pd 2056 26 respectively respectively RB cord-015365-iqdi99pd 2056 27 . . . cord-015365-iqdi99pd 2057 1 No no DT cord-015365-iqdi99pd 2057 2 grade grade NN cord-015365-iqdi99pd 2057 3 V v NN cord-015365-iqdi99pd 2057 4 reflux reflux NN cord-015365-iqdi99pd 2057 5 was be VBD cord-015365-iqdi99pd 2057 6 seen see VBN cord-015365-iqdi99pd 2057 7 . . . cord-015365-iqdi99pd 2058 1 VUR VUR NNP cord-015365-iqdi99pd 2058 2 showed show VBD cord-015365-iqdi99pd 2058 3 no no DT cord-015365-iqdi99pd 2058 4 significant significant JJ cord-015365-iqdi99pd 2058 5 impact impact NN cord-015365-iqdi99pd 2058 6 on on IN cord-015365-iqdi99pd 2058 7 death death NN cord-015365-iqdi99pd 2058 8 - - HYPH cord-015365-iqdi99pd 2058 9 censored censor VBN cord-015365-iqdi99pd 2058 10 graft graft NN cord-015365-iqdi99pd 2058 11 survival survival NN cord-015365-iqdi99pd 2058 12 , , , cord-015365-iqdi99pd 2058 13 patient patient JJ cord-015365-iqdi99pd 2058 14 survival survival NN cord-015365-iqdi99pd 2058 15 , , , cord-015365-iqdi99pd 2058 16 proteinuria proteinuria NN cord-015365-iqdi99pd 2058 17 or or CC cord-015365-iqdi99pd 2058 18 UTI UTI NNP cord-015365-iqdi99pd 2058 19 . . . cord-015365-iqdi99pd 2059 1 Patients patient NNS cord-015365-iqdi99pd 2059 2 with with IN cord-015365-iqdi99pd 2059 3 VUR VUR NNP cord-015365-iqdi99pd 2059 4 had have VBD cord-015365-iqdi99pd 2059 5 a a DT cord-015365-iqdi99pd 2059 6 significantly significantly RB cord-015365-iqdi99pd 2059 7 lower low JJR cord-015365-iqdi99pd 2059 8 GFR GFR NNP cord-015365-iqdi99pd 2059 9 at at IN cord-015365-iqdi99pd 2059 10 one one CD cord-015365-iqdi99pd 2059 11 year year NN cord-015365-iqdi99pd 2059 12 after after IN cord-015365-iqdi99pd 2059 13 transplantation transplantation NN cord-015365-iqdi99pd 2059 14 than than IN cord-015365-iqdi99pd 2059 15 patients patient NNS cord-015365-iqdi99pd 2059 16 without without IN cord-015365-iqdi99pd 2059 17 VUR VUR NNP cord-015365-iqdi99pd 2059 18 ( ( -LRB- cord-015365-iqdi99pd 2059 19 60 60 CD cord-015365-iqdi99pd 2059 20 vs. vs. NN cord-015365-iqdi99pd 2059 21 52 52 CD cord-015365-iqdi99pd 2059 22 ml ml NNS cord-015365-iqdi99pd 2059 23 / / SYM cord-015365-iqdi99pd 2059 24 min/1,73 min/1,73 CD cord-015365-iqdi99pd 2059 25 m m NNP cord-015365-iqdi99pd 2059 26 2 2 CD cord-015365-iqdi99pd 2059 27 , , , cord-015365-iqdi99pd 2059 28 p p NN cord-015365-iqdi99pd 2059 29 ¼ ¼ CD cord-015365-iqdi99pd 2059 30 0.021 0.021 CD cord-015365-iqdi99pd 2059 31 ) ) -RRB- cord-015365-iqdi99pd 2059 32 , , , cord-015365-iqdi99pd 2059 33 this this DT cord-015365-iqdi99pd 2059 34 difference difference NN cord-015365-iqdi99pd 2059 35 was be VBD cord-015365-iqdi99pd 2059 36 no no RB cord-015365-iqdi99pd 2059 37 longer long RBR cord-015365-iqdi99pd 2059 38 seen see VBN cord-015365-iqdi99pd 2059 39 at at IN cord-015365-iqdi99pd 2059 40 3 3 CD cord-015365-iqdi99pd 2059 41 and and CC cord-015365-iqdi99pd 2059 42 5 5 CD cord-015365-iqdi99pd 2059 43 years year NNS cord-015365-iqdi99pd 2059 44 . . . cord-015365-iqdi99pd 2060 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2060 2 . . . cord-015365-iqdi99pd 2061 1 Although although IN cord-015365-iqdi99pd 2061 2 VUR VUR NNP cord-015365-iqdi99pd 2061 3 is be VBZ cord-015365-iqdi99pd 2061 4 a a DT cord-015365-iqdi99pd 2061 5 common common JJ cord-015365-iqdi99pd 2061 6 finding finding NN cord-015365-iqdi99pd 2061 7 in in IN cord-015365-iqdi99pd 2061 8 patients patient NNS cord-015365-iqdi99pd 2061 9 after after IN cord-015365-iqdi99pd 2061 10 renal renal JJ cord-015365-iqdi99pd 2061 11 transplantation transplantation NN cord-015365-iqdi99pd 2061 12 , , , cord-015365-iqdi99pd 2061 13 it -PRON- PRP cord-015365-iqdi99pd 2061 14 has have VBZ cord-015365-iqdi99pd 2061 15 no no DT cord-015365-iqdi99pd 2061 16 impact impact NN cord-015365-iqdi99pd 2061 17 on on IN cord-015365-iqdi99pd 2061 18 death death NN cord-015365-iqdi99pd 2061 19 - - HYPH cord-015365-iqdi99pd 2061 20 censored censor VBN cord-015365-iqdi99pd 2061 21 graft graft NN cord-015365-iqdi99pd 2061 22 survival survival NN cord-015365-iqdi99pd 2061 23 , , , cord-015365-iqdi99pd 2061 24 patient patient JJ cord-015365-iqdi99pd 2061 25 survival survival NN cord-015365-iqdi99pd 2061 26 , , , cord-015365-iqdi99pd 2061 27 proteinuria proteinuria NN cord-015365-iqdi99pd 2061 28 or or CC cord-015365-iqdi99pd 2061 29 UTI UTI NNP cord-015365-iqdi99pd 2061 30 and and CC cord-015365-iqdi99pd 2061 31 only only RB cord-015365-iqdi99pd 2061 32 a a DT cord-015365-iqdi99pd 2061 33 short short JJ cord-015365-iqdi99pd 2061 34 term term NN cord-015365-iqdi99pd 2061 35 effect effect NN cord-015365-iqdi99pd 2061 36 on on IN cord-015365-iqdi99pd 2061 37 renal renal JJ cord-015365-iqdi99pd 2061 38 graft graft NN cord-015365-iqdi99pd 2061 39 function function NN cord-015365-iqdi99pd 2061 40 that that WDT cord-015365-iqdi99pd 2061 41 was be VBD cord-015365-iqdi99pd 2061 42 no no RB cord-015365-iqdi99pd 2061 43 longer long RBR cord-015365-iqdi99pd 2061 44 seen see VBN cord-015365-iqdi99pd 2061 45 in in IN cord-015365-iqdi99pd 2061 46 long long JJ cord-015365-iqdi99pd 2061 47 term term NN cord-015365-iqdi99pd 2061 48 follow follow VB cord-015365-iqdi99pd 2061 49 up up RP cord-015365-iqdi99pd 2061 50 . . . cord-015365-iqdi99pd 2062 1 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2062 2 . . . cord-015365-iqdi99pd 2063 1 Der Der NNP cord-015365-iqdi99pd 2063 2 Einfluss Einfluss NNP cord-015365-iqdi99pd 2063 3 von von NN cord-015365-iqdi99pd 2063 4 primär primär NN cord-015365-iqdi99pd 2063 5 unentdeckten unentdeckten NNP cord-015365-iqdi99pd 2063 6 hepatozelluären hepatozelluären NNP cord-015365-iqdi99pd 2064 1 Karzinomen Karzinomen NNP cord-015365-iqdi99pd 2064 2 ( ( -LRB- cord-015365-iqdi99pd 2064 3 HCC HCC NNP cord-015365-iqdi99pd 2064 4 ) ) -RRB- cord-015365-iqdi99pd 2064 5 auf auf NNP cord-015365-iqdi99pd 2064 6 das das NNP cord-015365-iqdi99pd 2064 7 Ü Ü NNP cord-015365-iqdi99pd 2064 8 berleben berleben NNP cord-015365-iqdi99pd 2064 9 nach nach NNP cord-015365-iqdi99pd 2064 10 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2064 11 wird wird NNP cord-015365-iqdi99pd 2064 12 in in IN cord-015365-iqdi99pd 2064 13 der der NNP cord-015365-iqdi99pd 2064 14 Literatur Literatur NNP cord-015365-iqdi99pd 2064 15 kontroversiell kontroversiell NNP cord-015365-iqdi99pd 2064 16 diskutiert diskutiert NNP cord-015365-iqdi99pd 2064 17 . . . cord-015365-iqdi99pd 2065 1 Ziel Ziel NNP cord-015365-iqdi99pd 2065 2 dieser dieser NNP cord-015365-iqdi99pd 2065 3 Studie Studie NNP cord-015365-iqdi99pd 2065 4 war war NN cord-015365-iqdi99pd 2065 5 es es NNP cord-015365-iqdi99pd 2065 6 , , , cord-015365-iqdi99pd 2065 7 die die VBP cord-015365-iqdi99pd 2065 8 Rate rate NN cord-015365-iqdi99pd 2065 9 von von NNP cord-015365-iqdi99pd 2065 10 okkulten okkulten VBN cord-015365-iqdi99pd 2065 11 Karzinomen Karzinomen NNP cord-015365-iqdi99pd 2065 12 in in IN cord-015365-iqdi99pd 2065 13 unserem unserem NNP cord-015365-iqdi99pd 2065 14 Kollektiv Kollektiv NNP cord-015365-iqdi99pd 2066 1 an an DT cord-015365-iqdi99pd 2066 2 äthyltoxischer äthyltoxischer NNP cord-015365-iqdi99pd 2066 3 Zirrhose Zirrhose NNP cord-015365-iqdi99pd 2066 4 erkrankter erkrankter NN cord-015365-iqdi99pd 2066 5 und und VBD cord-015365-iqdi99pd 2066 6 für für JJ cord-015365-iqdi99pd 2066 7 diese diese JJ cord-015365-iqdi99pd 2066 8 Indikation Indikation NNP cord-015365-iqdi99pd 2066 9 transplantierter transplantierter NN cord-015365-iqdi99pd 2066 10 Patienten Patienten NNP cord-015365-iqdi99pd 2066 11 der der NNP cord-015365-iqdi99pd 2066 12 letzten letzten NNP cord-015365-iqdi99pd 2066 13 10 10 CD cord-015365-iqdi99pd 2067 1 Jahre Jahre NNP cord-015365-iqdi99pd 2067 2 zu zu NNP cord-015365-iqdi99pd 2067 3 erheben erheben NNP cord-015365-iqdi99pd 2068 1 und und IN cord-015365-iqdi99pd 2068 2 den den NNP cord-015365-iqdi99pd 2068 3 Einfluss Einfluss NNP cord-015365-iqdi99pd 2068 4 auf auf NNP cord-015365-iqdi99pd 2068 5 das das NNP cord-015365-iqdi99pd 2068 6 rezidivfreie rezidivfreie XX cord-015365-iqdi99pd 2068 7 uund uund RB cord-015365-iqdi99pd 2068 8 Gesamtüberleben Gesamtüberleben NNP cord-015365-iqdi99pd 2068 9 nach nach NNP cord-015365-iqdi99pd 2068 10 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2068 11 zu zu NNP cord-015365-iqdi99pd 2068 12 untersuchen untersuchen NNP cord-015365-iqdi99pd 2068 13 . . . cord-015365-iqdi99pd 2069 1 Methodik Methodik NNP cord-015365-iqdi99pd 2069 2 . . . cord-015365-iqdi99pd 2070 1 Retropektive Retropektive NNP cord-015365-iqdi99pd 2070 2 Analyse Analyse NNP cord-015365-iqdi99pd 2070 3 von von NNP cord-015365-iqdi99pd 2070 4 285 285 CD cord-015365-iqdi99pd 2070 5 wegen wegen NNP cord-015365-iqdi99pd 2070 6 äthyltoxischer äthyltoxischer NNP cord-015365-iqdi99pd 2070 7 Zirrhose Zirrhose NNP cord-015365-iqdi99pd 2070 8 gelisteter gelisteter NNP cord-015365-iqdi99pd 2071 1 und und NNP cord-015365-iqdi99pd 2072 1 transplantierter transplantierter NNP cord-015365-iqdi99pd 2073 1 Patienten Patienten NNP cord-015365-iqdi99pd 2074 1 i -PRON- PRP cord-015365-iqdi99pd 2074 2 m be VBP cord-015365-iqdi99pd 2074 3 Zeitraum Zeitraum NNP cord-015365-iqdi99pd 2074 4 von von NNP cord-015365-iqdi99pd 2074 5 1998 1998 CD cord-015365-iqdi99pd 2075 1 bis bis NNP cord-015365-iqdi99pd 2075 2 2008 2008 CD cord-015365-iqdi99pd 2075 3 . . . cord-015365-iqdi99pd 2076 1 Neben Neben NNP cord-015365-iqdi99pd 2076 2 den den NNP cord-015365-iqdi99pd 2077 1 Baseline Baseline NNP cord-015365-iqdi99pd 2078 1 Parametern Parametern NNP cord-015365-iqdi99pd 2078 2 wurden wurden VBD cord-015365-iqdi99pd 2078 3 alle alle NNP cord-015365-iqdi99pd 2078 4 Explanthistologien Explanthistologien NNP cord-015365-iqdi99pd 2078 5 ausgewertet ausgewertet NNP cord-015365-iqdi99pd 2078 6 . . . cord-015365-iqdi99pd 2079 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2079 2 . . . cord-015365-iqdi99pd 2080 1 Dreizehn Dreizehn NNP cord-015365-iqdi99pd 2080 2 Patienten Patienten NNP cord-015365-iqdi99pd 2080 3 ( ( -LRB- cord-015365-iqdi99pd 2080 4 4,5 4,5 CD cord-015365-iqdi99pd 2080 5 % % NN cord-015365-iqdi99pd 2080 6 ) ) -RRB- cord-015365-iqdi99pd 2081 1 zeigten zeigten NNP cord-015365-iqdi99pd 2081 2 ein ein NNP cord-015365-iqdi99pd 2081 3 HCC HCC NNP cord-015365-iqdi99pd 2081 4 in in IN cord-015365-iqdi99pd 2081 5 der der NNP cord-015365-iqdi99pd 2081 6 Explanthistologie Explanthistologie NNP cord-015365-iqdi99pd 2081 7 . . . cord-015365-iqdi99pd 2082 1 Drei Drei NNP cord-015365-iqdi99pd 2082 2 Patienten Patienten NNP cord-015365-iqdi99pd 2082 3 waren waren XX cord-015365-iqdi99pd 2083 1 außerhalb außerhalb NNP cord-015365-iqdi99pd 2083 2 der der NNP cord-015365-iqdi99pd 2083 3 Mailand Mailand NNP cord-015365-iqdi99pd 2083 4 Kriterien Kriterien NNP cord-015365-iqdi99pd 2083 5 und und IN cord-015365-iqdi99pd 2083 6 19 19 CD cord-015365-iqdi99pd 2084 1 von von NNP cord-015365-iqdi99pd 2084 2 27 27 CD cord-015365-iqdi99pd 2084 3 Herden Herden NNP cord-015365-iqdi99pd 2084 4 waren waren NNS cord-015365-iqdi99pd 2085 1 größer größer NNP cord-015365-iqdi99pd 2085 2 als als NNP cord-015365-iqdi99pd 2085 3 1 1 CD cord-015365-iqdi99pd 2085 4 cm cm NN cord-015365-iqdi99pd 2085 5 . . . cord-015365-iqdi99pd 2086 1 Die die VB cord-015365-iqdi99pd 2086 2 Wartezeit Wartezeit NNP cord-015365-iqdi99pd 2086 3 der der NNP cord-015365-iqdi99pd 2086 4 Patienten Patienten NNP cord-015365-iqdi99pd 2086 5 betrug betrug NNP cord-015365-iqdi99pd 2087 1 i -PRON- PRP cord-015365-iqdi99pd 2087 2 m be VBP cord-015365-iqdi99pd 2087 3 Median median JJ cord-015365-iqdi99pd 2087 4 2,7 2,7 CD cord-015365-iqdi99pd 2087 5 Monate Monate NNP cord-015365-iqdi99pd 2087 6 . . . cord-015365-iqdi99pd 2088 1 Nach Nach NNP cord-015365-iqdi99pd 2088 2 2004 2004 CD cord-015365-iqdi99pd 2088 3 gab gab NN cord-015365-iqdi99pd 2089 1 es es NNP cord-015365-iqdi99pd 2089 2 keine keine NNP cord-015365-iqdi99pd 2089 3 okkulten okkulten NNP cord-015365-iqdi99pd 2089 4 HCCs HCCs NNP cord-015365-iqdi99pd 2089 5 in in IN cord-015365-iqdi99pd 2089 6 unserem unserem NNP cord-015365-iqdi99pd 2089 7 Kollektiv Kollektiv NNP cord-015365-iqdi99pd 2089 8 . . . cord-015365-iqdi99pd 2090 1 Ein Ein NNP cord-015365-iqdi99pd 2090 2 Ü Ü NNP cord-015365-iqdi99pd 2090 3 berlebensnachteil berlebensnachteil NN cord-015365-iqdi99pd 2091 1 fü fü IN cord-015365-iqdi99pd 2092 1 r r LS cord-015365-iqdi99pd 2092 2 Patienten Patienten NNP cord-015365-iqdi99pd 2092 3 mit mit NNP cord-015365-iqdi99pd 2093 1 okkultem okkultem IN cord-015365-iqdi99pd 2093 2 HCC HCC NNP cord-015365-iqdi99pd 2093 3 gegenü gegenü NN cord-015365-iqdi99pd 2093 4 ber ber NNP cord-015365-iqdi99pd 2093 5 der der NNP cord-015365-iqdi99pd 2093 6 Normalgruppe Normalgruppe NNP cord-015365-iqdi99pd 2093 7 konnte konnte NNP cord-015365-iqdi99pd 2093 8 in in IN cord-015365-iqdi99pd 2093 9 diesem diesem JJ cord-015365-iqdi99pd 2093 10 Kollektiv Kollektiv NNP cord-015365-iqdi99pd 2093 11 nicht nicht NNP cord-015365-iqdi99pd 2093 12 gezeigt gezeigt NNP cord-015365-iqdi99pd 2093 13 werden werden NNP cord-015365-iqdi99pd 2093 14 . . . cord-015365-iqdi99pd 2094 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2094 2 . . . cord-015365-iqdi99pd 2095 1 Die die VB cord-015365-iqdi99pd 2095 2 kurze kurze NNP cord-015365-iqdi99pd 2095 3 Wartezeit Wartezeit NNP cord-015365-iqdi99pd 2095 4 der der NNP cord-015365-iqdi99pd 2095 5 Patienten Patienten NNP cord-015365-iqdi99pd 2095 6 mit mit VBD cord-015365-iqdi99pd 2095 7 okkultem okkultem XX cord-015365-iqdi99pd 2096 1 HCC HCC NNP cord-015365-iqdi99pd 2096 2 sowie sowie NNP cord-015365-iqdi99pd 2096 3 die die VBP cord-015365-iqdi99pd 2096 4 Tumorgröße Tumorgröße NNP cord-015365-iqdi99pd 2096 5 legt legt NNP cord-015365-iqdi99pd 2096 6 nahe nahe NNP cord-015365-iqdi99pd 2096 7 , , , cord-015365-iqdi99pd 2096 8 dass dass NNP cord-015365-iqdi99pd 2096 9 bei bei NNP cord-015365-iqdi99pd 2096 10 diesen diesen NNP cord-015365-iqdi99pd 2096 11 Patienten Patienten NNP cord-015365-iqdi99pd 2096 12 bereits bereits NN cord-015365-iqdi99pd 2096 13 vor vor NNP cord-015365-iqdi99pd 2096 14 der der NNP cord-015365-iqdi99pd 2096 15 Listung Listung NNP cord-015365-iqdi99pd 2096 16 das das NNP cord-015365-iqdi99pd 2096 17 HCC HCC NNP cord-015365-iqdi99pd 2096 18 unentdeckt unentdeckt NNS cord-015365-iqdi99pd 2096 19 blieb blieb NNP cord-015365-iqdi99pd 2096 20 , , , cord-015365-iqdi99pd 2097 1 während während NNP cord-015365-iqdi99pd 2097 2 es es NNP cord-015365-iqdi99pd 2097 3 später später NNP cord-015365-iqdi99pd 2097 4 mit mit NNP cord-015365-iqdi99pd 2097 5 Verbesserung Verbesserung NNP cord-015365-iqdi99pd 2097 6 der der NNP cord-015365-iqdi99pd 2097 7 radiologischen radiologischen NNP cord-015365-iqdi99pd 2097 8 Technik Technik NNP cord-015365-iqdi99pd 2097 9 sowie sowie NNP cord-015365-iqdi99pd 2097 10 längerer längerer NNP cord-015365-iqdi99pd 2098 1 Wartezeit Wartezeit NNP cord-015365-iqdi99pd 2099 1 i -PRON- PRP cord-015365-iqdi99pd 2099 2 m be VBP cord-015365-iqdi99pd 2099 3 Rahmen Rahmen NNP cord-015365-iqdi99pd 2099 4 des des NNP cord-015365-iqdi99pd 2099 5 Screenings Screenings NNP cord-015365-iqdi99pd 2099 6 entdeckt entdeckt NN cord-015365-iqdi99pd 2099 7 wurde wurde FW cord-015365-iqdi99pd 2099 8 . . . cord-015365-iqdi99pd 2100 1 Rein Rein NNP cord-015365-iqdi99pd 2100 2 deskriptiv deskriptiv NNP cord-015365-iqdi99pd 2100 3 zeigte zeigte NNP cord-015365-iqdi99pd 2100 4 sich sich NNP cord-015365-iqdi99pd 2100 5 in in IN cord-015365-iqdi99pd 2100 6 unserem unserem NNP cord-015365-iqdi99pd 2100 7 Kollektiv Kollektiv NNP cord-015365-iqdi99pd 2100 8 kein kein NNP cord-015365-iqdi99pd 2100 9 Ü Ü NNP cord-015365-iqdi99pd 2100 10 berlebensnachteil berlebensnachteil NNP cord-015365-iqdi99pd 2100 11 für für NNP cord-015365-iqdi99pd 2100 12 Patienten Patienten NNP cord-015365-iqdi99pd 2100 13 mit mit NNP cord-015365-iqdi99pd 2100 14 okkultem okkultem NNP cord-015365-iqdi99pd 2100 15 HCC HCC NNP cord-015365-iqdi99pd 2100 16 . . . cord-015365-iqdi99pd 2101 1 Ist Ist NNP cord-015365-iqdi99pd 2101 2 die die VBP cord-015365-iqdi99pd 2101 3 ungeplante ungeplante JJ cord-015365-iqdi99pd 2101 4 Reoperation reoperation NN cord-015365-iqdi99pd 2101 5 nach nach NNP cord-015365-iqdi99pd 2101 6 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 2101 7 ein ein NNP cord-015365-iqdi99pd 2101 8 Indikator Indikator NNP cord-015365-iqdi99pd 2101 9 für für IN cord-015365-iqdi99pd 2101 10 Organverlust Organverlust NNP cord-015365-iqdi99pd 2101 11 ? ? . cord-015365-iqdi99pd 2102 1 K. K. NNP cord-015365-iqdi99pd 2102 2 Huber Huber NNP cord-015365-iqdi99pd 2102 3 1 1 CD cord-015365-iqdi99pd 2102 4 , , , cord-015365-iqdi99pd 2102 5 A. A. NNP cord-015365-iqdi99pd 2102 6 Krause Krause NNP cord-015365-iqdi99pd 2102 7 1 1 CD cord-015365-iqdi99pd 2102 8 , , , cord-015365-iqdi99pd 2102 9 O. O. NNP cord-015365-iqdi99pd 2102 10 Gangl Gangl NNP cord-015365-iqdi99pd 2102 11 1 1 CD cord-015365-iqdi99pd 2102 12 , , , cord-015365-iqdi99pd 2102 13 W. W. NNP cord-015365-iqdi99pd 2102 14 Enkner Enkner NNP cord-015365-iqdi99pd 2102 15 2 2 CD cord-015365-iqdi99pd 2102 16 , , , cord-015365-iqdi99pd 2102 17 R. R. NNP cord-015365-iqdi99pd 2102 18 Oberbauer Oberbauer NNP cord-015365-iqdi99pd 2102 19 2 2 CD cord-015365-iqdi99pd 2102 20 , , , cord-015365-iqdi99pd 2102 21 R. R. NNP cord-015365-iqdi99pd 2102 22 Függer Függer NNP cord-015365-iqdi99pd 2102 23 1 1 CD cord-015365-iqdi99pd 2102 24 Ö Ö NNP cord-015365-iqdi99pd 2102 25 sophagusvarizen sophagusvarizen NN cord-015365-iqdi99pd 2103 1 ( ( -LRB- cord-015365-iqdi99pd 2103 2 Grad Grad NNP cord-015365-iqdi99pd 2103 3 II II NNP cord-015365-iqdi99pd 2103 4 ; ; : cord-015365-iqdi99pd 2103 5 > > NFP cord-015365-iqdi99pd 2103 6 5 5 CD cord-015365-iqdi99pd 2103 7 mm mm NN cord-015365-iqdi99pd 2103 8 unter unter JJ cord-015365-iqdi99pd 2103 9 Insufflation Insufflation NNP cord-015365-iqdi99pd 2103 10 ) ) -RRB- cord-015365-iqdi99pd 2104 1 während während NNP cord-015365-iqdi99pd 2104 2 der der NNP cord-015365-iqdi99pd 2104 3 oLT oLT NNP cord-015365-iqdi99pd 2105 1 aufgetreten aufgetreten NNP cord-015365-iqdi99pd 2105 2 sind sind NNP cord-015365-iqdi99pd 2105 3 und und NNP cord-015365-iqdi99pd 2105 4 mittels mittels NNPS cord-015365-iqdi99pd 2105 5 Ballontamponade Ballontamponade NNP cord-015365-iqdi99pd 2105 6 behandelt behandelt NNP cord-015365-iqdi99pd 2105 7 wurden wurden VBD cord-015365-iqdi99pd 2105 8 . . . cord-015365-iqdi99pd 2106 1 Vergleicht Vergleicht NNP cord-015365-iqdi99pd 2106 2 man man NN cord-015365-iqdi99pd 2106 3 die die VB cord-015365-iqdi99pd 2106 4 beiden beiden JJ cord-015365-iqdi99pd 2106 5 Patientenkollektive Patientenkollektive NNP cord-015365-iqdi99pd 2106 6 ( ( -LRB- cord-015365-iqdi99pd 2106 7 mit mit NNP cord-015365-iqdi99pd 2106 8 und und NNP cord-015365-iqdi99pd 2106 9 ohne ohne NNP cord-015365-iqdi99pd 2106 10 Krampfadern Krampfadern NNP cord-015365-iqdi99pd 2106 11 ) ) -RRB- cord-015365-iqdi99pd 2106 12 , , , cord-015365-iqdi99pd 2106 13 so so RB cord-015365-iqdi99pd 2106 14 ist ist FW cord-015365-iqdi99pd 2106 15 das das NNP cord-015365-iqdi99pd 2106 16 Ergebnis Ergebnis NNP cord-015365-iqdi99pd 2106 17 statistisch statistisch NNP cord-015365-iqdi99pd 2106 18 nicht nicht NNP cord-015365-iqdi99pd 2106 19 signifikant signifikant NNP cord-015365-iqdi99pd 2106 20 : : : cord-015365-iqdi99pd 2106 21 Chi Chi NNP cord-015365-iqdi99pd 2106 22 - - HYPH cord-015365-iqdi99pd 2106 23 Quadrat Quadrat NNP cord-015365-iqdi99pd 2106 24 - - HYPH cord-015365-iqdi99pd 2106 25 Test Test NNP cord-015365-iqdi99pd 2106 26 , , , cord-015365-iqdi99pd 2106 27 p p NN cord-015365-iqdi99pd 2106 28 ¼ ¼ NNP cord-015365-iqdi99pd 2106 29 0,61 0,61 CD cord-015365-iqdi99pd 2106 30 . . . cord-015365-iqdi99pd 2107 1 Alle Alle NNP cord-015365-iqdi99pd 2107 2 Patienten Patienten NNP cord-015365-iqdi99pd 2107 3 erhielten erhielten NN cord-015365-iqdi99pd 2108 1 i i PRP cord-015365-iqdi99pd 2109 1 m m NNP cord-015365-iqdi99pd 2109 2 Median Median NNP cord-015365-iqdi99pd 2109 3 2 2 CD cord-015365-iqdi99pd 2110 1 Einheiten Einheiten NNP cord-015365-iqdi99pd 2110 2 Erythrozytenkonzentrate Erythrozytenkonzentrate NNP cord-015365-iqdi99pd 2110 3 ( ( -LRB- cord-015365-iqdi99pd 2110 4 Bereich Bereich NNP cord-015365-iqdi99pd 2110 5 0 0 CD cord-015365-iqdi99pd 2110 6 bis bis NNP cord-015365-iqdi99pd 2110 7 70 70 CD cord-015365-iqdi99pd 2110 8 Einheiten Einheiten NNP cord-015365-iqdi99pd 2110 9 ) ) -RRB- cord-015365-iqdi99pd 2110 10 , , , cord-015365-iqdi99pd 2110 11 7 7 CD cord-015365-iqdi99pd 2110 12 Einheiten Einheiten NNP cord-015365-iqdi99pd 2110 13 Fresh Fresh NNP cord-015365-iqdi99pd 2110 14 Frozen Frozen NNP cord-015365-iqdi99pd 2110 15 Plasma Plasma NNP cord-015365-iqdi99pd 2110 16 ( ( -LRB- cord-015365-iqdi99pd 2110 17 Bereich Bereich NNP cord-015365-iqdi99pd 2110 18 von von NNP cord-015365-iqdi99pd 2110 19 0 0 CD cord-015365-iqdi99pd 2110 20 bis bis NNP cord-015365-iqdi99pd 2110 21 60 60 CD cord-015365-iqdi99pd 2110 22 Einheiten Einheiten NNP cord-015365-iqdi99pd 2110 23 ) ) -RRB- cord-015365-iqdi99pd 2110 24 und und RB cord-015365-iqdi99pd 2111 1 0 0 NFP cord-015365-iqdi99pd 2111 2 Thrombozytenkonzentrate Thrombozytenkonzentrate NNP cord-015365-iqdi99pd 2111 3 ( ( -LRB- cord-015365-iqdi99pd 2111 4 Bereich Bereich NNP cord-015365-iqdi99pd 2111 5 0 0 CD cord-015365-iqdi99pd 2111 6 bis bis NN cord-015365-iqdi99pd 2111 7 4 4 CD cord-015365-iqdi99pd 2111 8 Einheiten Einheiten NNP cord-015365-iqdi99pd 2111 9 ) ) -RRB- cord-015365-iqdi99pd 2111 10 . . . cord-015365-iqdi99pd 2112 1 Obwohl Obwohl NNP cord-015365-iqdi99pd 2112 2 Patienten Patienten NNP cord-015365-iqdi99pd 2112 3 mit mit NNP cord-015365-iqdi99pd 2112 4 Krampfadern Krampfadern NNP cord-015365-iqdi99pd 2113 1 eine eine NNP cord-015365-iqdi99pd 2113 2 signifikant signifikant NNP cord-015365-iqdi99pd 2113 3 längere längere NNP cord-015365-iqdi99pd 2113 4 Prothrombinzeit Prothrombinzeit NNP cord-015365-iqdi99pd 2113 5 und und XX cord-015365-iqdi99pd 2114 1 eine eine NNP cord-015365-iqdi99pd 2114 2 geringere geringere NNP cord-015365-iqdi99pd 2114 3 Thrombozytenzahl Thrombozytenzahl NNP cord-015365-iqdi99pd 2114 4 aufwiesen aufwiesen NNP cord-015365-iqdi99pd 2114 5 , , , cord-015365-iqdi99pd 2114 6 bestand bestand VB cord-015365-iqdi99pd 2114 7 gegenü gegenü NNP cord-015365-iqdi99pd 2114 8 ber ber NNP cord-015365-iqdi99pd 2114 9 Patienten Patienten NNP cord-015365-iqdi99pd 2114 10 ohne ohne NNP cord-015365-iqdi99pd 2114 11 Varizen Varizen NNP cord-015365-iqdi99pd 2114 12 kein kein NNP cord-015365-iqdi99pd 2114 13 Unterschied Unterschied NNP cord-015365-iqdi99pd 2114 14 in in IN cord-015365-iqdi99pd 2114 15 der der NNP cord-015365-iqdi99pd 2114 16 Verwendung Verwendung NNP cord-015365-iqdi99pd 2114 17 von von NNP cord-015365-iqdi99pd 2114 18 Blutprodukten Blutprodukten NNP cord-015365-iqdi99pd 2114 19 . . . cord-015365-iqdi99pd 2115 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2115 2 . . . cord-015365-iqdi99pd 2116 1 Die die VB cord-015365-iqdi99pd 2117 1 TEE tee NN cord-015365-iqdi99pd 2117 2 scheint scheint NNP cord-015365-iqdi99pd 2117 3 bei bei NNP cord-015365-iqdi99pd 2117 4 oLT oLT NNP cord-015365-iqdi99pd 2118 1 Patienten Patienten NNP cord-015365-iqdi99pd 2118 2 mit mit VBP cord-015365-iqdi99pd 2118 3 dokumentierten dokumentierten NNP cord-015365-iqdi99pd 2118 4 Ö Ö NNP cord-015365-iqdi99pd 2118 5 sophagusvarizen sophagusvarizen NNP cord-015365-iqdi99pd 2118 6 eine eine NNP cord-015365-iqdi99pd 2118 7 allgemein allgemein NNP cord-015365-iqdi99pd 2118 8 sichere sichere NNP cord-015365-iqdi99pd 2118 9 Methode Methode NNP cord-015365-iqdi99pd 2118 10 zur zur NNP cord-015365-iqdi99pd 2118 11 Kontrolle Kontrolle NNP cord-015365-iqdi99pd 2118 12 der der NN cord-015365-iqdi99pd 2118 13 Herzfunktion Herzfunktion NNP cord-015365-iqdi99pd 2118 14 zu zu NNP cord-015365-iqdi99pd 2118 15 sein sein NNP cord-015365-iqdi99pd 2118 16 . . . cord-015365-iqdi99pd 2119 1 Entwicklung Entwicklung NNP cord-015365-iqdi99pd 2119 2 des des NNP cord-015365-iqdi99pd 2119 3 Anteils Anteils NNP cord-015365-iqdi99pd 2119 4 an an DT cord-015365-iqdi99pd 2120 1 Leberspendern Leberspendern NNP cord-015365-iqdi99pd 2120 2 mit mit NNP cord-015365-iqdi99pd 2120 3 erweiterten erweiterten VBN cord-015365-iqdi99pd 2120 4 Spenderkriterien Spenderkriterien NNP cord-015365-iqdi99pd 2120 5 innerhalb innerhalb NNP cord-015365-iqdi99pd 2120 6 der der NNP cord-015365-iqdi99pd 2120 7 letzten letzten NNP cord-015365-iqdi99pd 2120 8 Dekade Dekade NNP cord-015365-iqdi99pd 2120 9 an an DT cord-015365-iqdi99pd 2120 10 der der NN cord-015365-iqdi99pd 2120 11 Universitätsklinik Universitätsklinik NNP cord-015365-iqdi99pd 2120 12 für für IN cord-015365-iqdi99pd 2120 13 Transplantationschirurgie Transplantationschirurgie NNP cord-015365-iqdi99pd 2120 14 Wien Wien NNP cord-015365-iqdi99pd 2120 15 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2120 16 . . . cord-015365-iqdi99pd 2121 1 Die die VB cord-015365-iqdi99pd 2121 2 Anzahl Anzahl NNP cord-015365-iqdi99pd 2121 3 der der NNP cord-015365-iqdi99pd 2121 4 jährlich jährlich NNP cord-015365-iqdi99pd 2121 5 durchgeführten durchgeführten NNP cord-015365-iqdi99pd 2122 1 Lebertransplantationen Lebertransplantationen NNP cord-015365-iqdi99pd 2122 2 ist ist NN cord-015365-iqdi99pd 2122 3 von von NNP cord-015365-iqdi99pd 2122 4 der der NNP cord-015365-iqdi99pd 2122 5 Anzahl Anzahl NNP cord-015365-iqdi99pd 2122 6 der der NNP cord-015365-iqdi99pd 2122 7 gemeldeten gemeldeten VBN cord-015365-iqdi99pd 2122 8 Organspender Organspender NNP cord-015365-iqdi99pd 2122 9 abhängig abhängig NNS cord-015365-iqdi99pd 2122 10 . . . cord-015365-iqdi99pd 2123 1 Allerdings Allerdings NNP cord-015365-iqdi99pd 2123 2 eignet eignet VBZ cord-015365-iqdi99pd 2123 3 sich sich NNP cord-015365-iqdi99pd 2123 4 nicht nicht NNP cord-015365-iqdi99pd 2123 5 jeder jeder NNP cord-015365-iqdi99pd 2123 6 Organspender Organspender NNP cord-015365-iqdi99pd 2123 7 als als NN cord-015365-iqdi99pd 2123 8 Leberspender Leberspender NNP cord-015365-iqdi99pd 2123 9 . . . cord-015365-iqdi99pd 2124 1 Ziel Ziel NNP cord-015365-iqdi99pd 2124 2 dieser dieser NNP cord-015365-iqdi99pd 2124 3 Studie Studie NNP cord-015365-iqdi99pd 2124 4 ist ist NNP cord-015365-iqdi99pd 2124 5 es es NNP cord-015365-iqdi99pd 2124 6 , , , cord-015365-iqdi99pd 2124 7 die die VB cord-015365-iqdi99pd 2125 1 Evolution evolution NN cord-015365-iqdi99pd 2125 2 der der NN cord-015365-iqdi99pd 2125 3 Leberspender Leberspender NNP cord-015365-iqdi99pd 2125 4 innerhalb innerhalb NNP cord-015365-iqdi99pd 2125 5 der der NNP cord-015365-iqdi99pd 2125 6 letzten letzten NNP cord-015365-iqdi99pd 2125 7 10 10 CD cord-015365-iqdi99pd 2125 8 Jahre Jahre NNP cord-015365-iqdi99pd 2125 9 zu zu NNP cord-015365-iqdi99pd 2125 10 verfolgen verfolgen NNP cord-015365-iqdi99pd 2125 11 . . . cord-015365-iqdi99pd 2126 1 Methodik Methodik NNP cord-015365-iqdi99pd 2126 2 Methodik Methodik NNP cord-015365-iqdi99pd 2126 3 . . . cord-015365-iqdi99pd 2127 1 I -PRON- PRP cord-015365-iqdi99pd 2127 2 m be VBP cord-015365-iqdi99pd 2127 3 Zeitraum Zeitraum NNP cord-015365-iqdi99pd 2127 4 von von NNP cord-015365-iqdi99pd 2127 5 Jänner Jänner NNP cord-015365-iqdi99pd 2127 6 1994 1994 CD cord-015365-iqdi99pd 2127 7 bis bis NNP cord-015365-iqdi99pd 2127 8 Juli Juli NNP cord-015365-iqdi99pd 2127 9 2011 2011 CD cord-015365-iqdi99pd 2127 10 wurden wurden NNP cord-015365-iqdi99pd 2127 11 an an DT cord-015365-iqdi99pd 2127 12 der der NN cord-015365-iqdi99pd 2127 13 Medizinischen Medizinischen NNP cord-015365-iqdi99pd 2127 14 Universität Universität NNP cord-015365-iqdi99pd 2127 15 Wien Wien NNP cord-015365-iqdi99pd 2127 16 , , , cord-015365-iqdi99pd 2127 17 Abteilung Abteilung NNP cord-015365-iqdi99pd 2127 18 für für IN cord-015365-iqdi99pd 2127 19 Transplantation Transplantation NNP cord-015365-iqdi99pd 2128 1 22 22 CD cord-015365-iqdi99pd 2129 1 Patienten Patienten NNP cord-015365-iqdi99pd 2129 2 , , , cord-015365-iqdi99pd 2129 3 davon davon NNP cord-015365-iqdi99pd 2129 4 18 18 CD cord-015365-iqdi99pd 2129 5 männlich männlich NNP cord-015365-iqdi99pd 2129 6 und und IN cord-015365-iqdi99pd 2129 7 4 4 CD cord-015365-iqdi99pd 2129 8 weiblich weiblich NNP cord-015365-iqdi99pd 2129 9 , , , cord-015365-iqdi99pd 2129 10 mit mit NNP cord-015365-iqdi99pd 2129 11 einem einem NNP cord-015365-iqdi99pd 2129 12 medianen medianen NNP cord-015365-iqdi99pd 2129 13 Durchschnittsalter Durchschnittsalter NNP cord-015365-iqdi99pd 2129 14 von von NNP cord-015365-iqdi99pd 2129 15 51 51 CD cord-015365-iqdi99pd 2129 16 Jahren Jahren NNP cord-015365-iqdi99pd 2129 17 kombiniert kombiniert NNP cord-015365-iqdi99pd 2129 18 Leber Leber NNP cord-015365-iqdi99pd 2129 19 und und IN cord-015365-iqdi99pd 2129 20 Niere Niere NNP cord-015365-iqdi99pd 2129 21 transplantiert transplantiert NNP cord-015365-iqdi99pd 2129 22 . . . cord-015365-iqdi99pd 2130 1 Inkludiert inkludiert JJ cord-015365-iqdi99pd 2130 2 wurden wurden VBD cord-015365-iqdi99pd 2130 3 bei bei NNP cord-015365-iqdi99pd 2130 4 dieser dieser NNP cord-015365-iqdi99pd 2130 5 retrospektiven retrospektiven NNP cord-015365-iqdi99pd 2130 6 Analyse Analyse NNP cord-015365-iqdi99pd 2130 7 nur nur NNP cord-015365-iqdi99pd 2130 8 einzeitig einzeitig NN cord-015365-iqdi99pd 2130 9 transplantierte transplantierte NNS cord-015365-iqdi99pd 2130 10 Patienten Patienten NNP cord-015365-iqdi99pd 2130 11 . . . cord-015365-iqdi99pd 2131 1 Die die VB cord-015365-iqdi99pd 2131 2 Indikationen Indikationen NNP cord-015365-iqdi99pd 2131 3 zur zur NNP cord-015365-iqdi99pd 2131 4 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2131 5 waren waren XX cord-015365-iqdi99pd 2132 1 wie wie NNP cord-015365-iqdi99pd 2132 2 folgt folgt NNP cord-015365-iqdi99pd 2132 3 verteilt verteilt NNP cord-015365-iqdi99pd 2132 4 : : : cord-015365-iqdi99pd 2133 1 Virushepatitis Virushepatitis NNP cord-015365-iqdi99pd 2133 2 ( ( -LRB- cord-015365-iqdi99pd 2133 3 n n CC cord-015365-iqdi99pd 2133 4 ¼ ¼ NNP cord-015365-iqdi99pd 2133 5 6 6 CD cord-015365-iqdi99pd 2133 6 ) ) -RRB- cord-015365-iqdi99pd 2133 7 , , , cord-015365-iqdi99pd 2133 8 Malignom Malignom NNP cord-015365-iqdi99pd 2133 9 ( ( -LRB- cord-015365-iqdi99pd 2133 10 n n CC cord-015365-iqdi99pd 2133 11 ¼ ¼ NNP cord-015365-iqdi99pd 2133 12 4 4 CD cord-015365-iqdi99pd 2133 13 ) ) -RRB- cord-015365-iqdi99pd 2133 14 , , , cord-015365-iqdi99pd 2133 15 metabolische metabolische NNP cord-015365-iqdi99pd 2133 16 Zirrhose Zirrhose NNP cord-015365-iqdi99pd 2134 1 ( ( -LRB- cord-015365-iqdi99pd 2134 2 n n JJ cord-015365-iqdi99pd 2134 3 ¼ ¼ NNP cord-015365-iqdi99pd 2134 4 5 5 CD cord-015365-iqdi99pd 2134 5 ) ) -RRB- cord-015365-iqdi99pd 2134 6 , , , cord-015365-iqdi99pd 2134 7 Oxalose Oxalose NNP cord-015365-iqdi99pd 2134 8 ( ( -LRB- cord-015365-iqdi99pd 2134 9 n n NN cord-015365-iqdi99pd 2134 10 ¼ ¼ NNP cord-015365-iqdi99pd 2134 11 3 3 CD cord-015365-iqdi99pd 2134 12 ) ) -RRB- cord-015365-iqdi99pd 2134 13 , , , cord-015365-iqdi99pd 2134 14 sklerosierende sklerosierende NNP cord-015365-iqdi99pd 2134 15 Cholangitis Cholangitis NNP cord-015365-iqdi99pd 2134 16 ( ( -LRB- cord-015365-iqdi99pd 2134 17 n n NN cord-015365-iqdi99pd 2134 18 ¼ ¼ NNP cord-015365-iqdi99pd 2134 19 1 1 CD cord-015365-iqdi99pd 2134 20 ) ) -RRB- cord-015365-iqdi99pd 2134 21 , , , cord-015365-iqdi99pd 2134 22 Hämochromatose Hämochromatose NNP cord-015365-iqdi99pd 2134 23 ( ( -LRB- cord-015365-iqdi99pd 2134 24 n n NNP cord-015365-iqdi99pd 2134 25 ¼ ¼ NNP cord-015365-iqdi99pd 2134 26 1 1 CD cord-015365-iqdi99pd 2134 27 ) ) -RRB- cord-015365-iqdi99pd 2134 28 , , , cord-015365-iqdi99pd 2134 29 Citrullinämie Citrullinämie NNP cord-015365-iqdi99pd 2134 30 ( ( -LRB- cord-015365-iqdi99pd 2134 31 n n NNP cord-015365-iqdi99pd 2134 32 ¼ ¼ NNP cord-015365-iqdi99pd 2134 33 1 1 CD cord-015365-iqdi99pd 2134 34 ) ) -RRB- cord-015365-iqdi99pd 2135 1 und und NNP cord-015365-iqdi99pd 2136 1 zystische zystische NNP cord-015365-iqdi99pd 2136 2 Zirrhose Zirrhose NNP cord-015365-iqdi99pd 2137 1 ( ( -LRB- cord-015365-iqdi99pd 2137 2 n n CC cord-015365-iqdi99pd 2137 3 ¼ ¼ NNP cord-015365-iqdi99pd 2137 4 1 1 CD cord-015365-iqdi99pd 2137 5 ) ) -RRB- cord-015365-iqdi99pd 2137 6 . . . cord-015365-iqdi99pd 2138 1 Die die VB cord-015365-iqdi99pd 2138 2 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 2138 3 erfolgte erfolgte NN cord-015365-iqdi99pd 2139 1 aufgrund aufgrund NNP cord-015365-iqdi99pd 2139 2 von von NNP cord-015365-iqdi99pd 2139 3 : : : cord-015365-iqdi99pd 2140 1 chronischer chronischer NNP cord-015365-iqdi99pd 2141 1 Niereninsuffizienz Niereninsuffizienz NNP cord-015365-iqdi99pd 2141 2 o. o. NNP cord-015365-iqdi99pd 2141 3 n. n. NN cord-015365-iqdi99pd 2141 4 B. B. NNP cord-015365-iqdi99pd 2142 1 ( ( -LRB- cord-015365-iqdi99pd 2142 2 n n CC cord-015365-iqdi99pd 2142 3 ¼ ¼ NNP cord-015365-iqdi99pd 2142 4 7 7 CD cord-015365-iqdi99pd 2142 5 ) ) -RRB- cord-015365-iqdi99pd 2142 6 , , , cord-015365-iqdi99pd 2142 7 Glomerulonephritis Glomerulonephritis NNP cord-015365-iqdi99pd 2142 8 ( ( -LRB- cord-015365-iqdi99pd 2142 9 n n CC cord-015365-iqdi99pd 2142 10 ¼ ¼ NNP cord-015365-iqdi99pd 2142 11 4 4 CD cord-015365-iqdi99pd 2142 12 ) ) -RRB- cord-015365-iqdi99pd 2142 13 , , , cord-015365-iqdi99pd 2142 14 metabolischer metabolischer NNP cord-015365-iqdi99pd 2142 15 Nephropathie Nephropathie NNP cord-015365-iqdi99pd 2142 16 ( ( -LRB- cord-015365-iqdi99pd 2142 17 n n NN cord-015365-iqdi99pd 2142 18 ¼ ¼ NNP cord-015365-iqdi99pd 2142 19 4 4 CD cord-015365-iqdi99pd 2142 20 ) ) -RRB- cord-015365-iqdi99pd 2142 21 , , , cord-015365-iqdi99pd 2142 22 Oxalose Oxalose NNP cord-015365-iqdi99pd 2142 23 ( ( -LRB- cord-015365-iqdi99pd 2142 24 n n NN cord-015365-iqdi99pd 2142 25 ¼ ¼ NNP cord-015365-iqdi99pd 2142 26 3 3 CD cord-015365-iqdi99pd 2142 27 ) ) -RRB- cord-015365-iqdi99pd 2142 28 , , , cord-015365-iqdi99pd 2142 29 Pyelonephritis Pyelonephritis NNP cord-015365-iqdi99pd 2142 30 ( ( -LRB- cord-015365-iqdi99pd 2142 31 n n CC cord-015365-iqdi99pd 2142 32 ¼ ¼ NNP cord-015365-iqdi99pd 2142 33 1 1 CD cord-015365-iqdi99pd 2142 34 ) ) -RRB- cord-015365-iqdi99pd 2142 35 , , , cord-015365-iqdi99pd 2142 36 Hantavirus Hantavirus NNP cord-015365-iqdi99pd 2142 37 ( ( -LRB- cord-015365-iqdi99pd 2142 38 n n NN cord-015365-iqdi99pd 2142 39 ¼ ¼ NNP cord-015365-iqdi99pd 2142 40 1 1 CD cord-015365-iqdi99pd 2142 41 ) ) -RRB- cord-015365-iqdi99pd 2142 42 , , , cord-015365-iqdi99pd 2142 43 IgA IgA NNP cord-015365-iqdi99pd 2142 44 - - HYPH cord-015365-iqdi99pd 2142 45 Nephropathie Nephropathie NNP cord-015365-iqdi99pd 2142 46 ( ( -LRB- cord-015365-iqdi99pd 2142 47 n n NN cord-015365-iqdi99pd 2142 48 ¼ ¼ NNP cord-015365-iqdi99pd 2142 49 1 1 CD cord-015365-iqdi99pd 2142 50 ) ) -RRB- cord-015365-iqdi99pd 2142 51 und und CC cord-015365-iqdi99pd 2142 52 Cyclosporin Cyclosporin NNP cord-015365-iqdi99pd 2142 53 - - HYPH cord-015365-iqdi99pd 2142 54 induziert induziert NNP cord-015365-iqdi99pd 2142 55 ( ( -LRB- cord-015365-iqdi99pd 2142 56 n n NN cord-015365-iqdi99pd 2142 57 ¼ ¼ NNP cord-015365-iqdi99pd 2142 58 1 1 CD cord-015365-iqdi99pd 2142 59 ) ) -RRB- cord-015365-iqdi99pd 2142 60 . . . cord-015365-iqdi99pd 2143 1 72 72 CD cord-015365-iqdi99pd 2143 2 % % NN cord-015365-iqdi99pd 2143 3 ( ( -LRB- cord-015365-iqdi99pd 2143 4 n n NN cord-015365-iqdi99pd 2143 5 ¼ ¼ NNP cord-015365-iqdi99pd 2143 6 16 16 CD cord-015365-iqdi99pd 2143 7 ) ) -RRB- cord-015365-iqdi99pd 2143 8 der der NNP cord-015365-iqdi99pd 2143 9 Patienten Patienten NNP cord-015365-iqdi99pd 2143 10 waren waren NN cord-015365-iqdi99pd 2143 11 zum zum NNP cord-015365-iqdi99pd 2143 12 Zeitpunkt Zeitpunkt NNP cord-015365-iqdi99pd 2143 13 der der NNP cord-015365-iqdi99pd 2143 14 Transplantation Transplantation NNP cord-015365-iqdi99pd 2143 15 dialysepflichtig dialysepflichtig NN cord-015365-iqdi99pd 2143 16 , , , cord-015365-iqdi99pd 2143 17 davon davon NNP cord-015365-iqdi99pd 2143 18 13 13 CD cord-015365-iqdi99pd 2144 1 an an DT cord-015365-iqdi99pd 2144 2 der der NN cord-015365-iqdi99pd 2144 3 Hämodialyse Hämodialyse NNP cord-015365-iqdi99pd 2144 4 und und IN cord-015365-iqdi99pd 2145 1 3 3 CD cord-015365-iqdi99pd 2145 2 erhielten erhielten NNP cord-015365-iqdi99pd 2145 3 Peritonealdialyse Peritonealdialyse NNP cord-015365-iqdi99pd 2145 4 . . . cord-015365-iqdi99pd 2146 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2146 2 . . . cord-015365-iqdi99pd 2147 1 Die die VB cord-015365-iqdi99pd 2148 1 Patienten Patienten NNP cord-015365-iqdi99pd 2148 2 waren waren VBD cord-015365-iqdi99pd 2148 3 durchschnittliche durchschnittliche NNP cord-015365-iqdi99pd 2148 4 121 121 CD cord-015365-iqdi99pd 2148 5 Tage Tage NNP cord-015365-iqdi99pd 2148 6 gleichzeitig gleichzeitig NNP cord-015365-iqdi99pd 2148 7 für für IN cord-015365-iqdi99pd 2148 8 Leber Leber NNP cord-015365-iqdi99pd 2148 9 und und IN cord-015365-iqdi99pd 2148 10 Niere Niere NNP cord-015365-iqdi99pd 2148 11 gelistet gelistet NNP cord-015365-iqdi99pd 2149 1 und und NNP cord-015365-iqdi99pd 2149 2 der der NNP cord-015365-iqdi99pd 2149 3 mediane mediane NNP cord-015365-iqdi99pd 2149 4 MELD MELD NNP cord-015365-iqdi99pd 2149 5 ( ( -LRB- cord-015365-iqdi99pd 2149 6 Model model NN cord-015365-iqdi99pd 2149 7 for for IN cord-015365-iqdi99pd 2149 8 End end NN cord-015365-iqdi99pd 2149 9 - - HYPH cord-015365-iqdi99pd 2149 10 Stage stage NN cord-015365-iqdi99pd 2149 11 Liver Liver NNP cord-015365-iqdi99pd 2149 12 Disease Disease NNP cord-015365-iqdi99pd 2149 13 ) ) -RRB- cord-015365-iqdi99pd 2150 1 Score Score NNP cord-015365-iqdi99pd 2150 2 betrug betrug NNP cord-015365-iqdi99pd 2150 3 bei bei NNP cord-015365-iqdi99pd 2150 4 Transplantation Transplantation NNP cord-015365-iqdi99pd 2150 5 22 22 CD cord-015365-iqdi99pd 2150 6 . . . cord-015365-iqdi99pd 2151 1 Die die VB cord-015365-iqdi99pd 2151 2 1-und 1-und CD cord-015365-iqdi99pd 2151 3 5-Jahresüberlebensrate 5-Jahresüberlebensrate NNP cord-015365-iqdi99pd 2151 4 betrug betrug NNP cord-015365-iqdi99pd 2151 5 bei bei NNP cord-015365-iqdi99pd 2151 6 unseren unseren NNP cord-015365-iqdi99pd 2152 1 Patienten Patienten NNP cord-015365-iqdi99pd 2152 2 81 81 CD cord-015365-iqdi99pd 2152 3 % % NN cord-015365-iqdi99pd 2152 4 und und IN cord-015365-iqdi99pd 2152 5 67 67 CD cord-015365-iqdi99pd 2152 6 % % NN cord-015365-iqdi99pd 2152 7 . . . cord-015365-iqdi99pd 2153 1 Unmittelbar Unmittelbar NNP cord-015365-iqdi99pd 2153 2 postoperativ postoperativ JJ cord-015365-iqdi99pd 2153 3 verstarben verstarben NN cord-015365-iqdi99pd 2154 1 3 3 CD cord-015365-iqdi99pd 2154 2 Patienten Patienten NNP cord-015365-iqdi99pd 2154 3 , , , cord-015365-iqdi99pd 2154 4 davon davon NNP cord-015365-iqdi99pd 2154 5 2 2 CD cord-015365-iqdi99pd 2154 6 an an DT cord-015365-iqdi99pd 2154 7 einer einer NNP cord-015365-iqdi99pd 2154 8 Sepsis sepsis NN cord-015365-iqdi99pd 2154 9 und und IN cord-015365-iqdi99pd 2154 10 einer einer NNP cord-015365-iqdi99pd 2154 11 in in IN cord-015365-iqdi99pd 2154 12 Folge Folge NNP cord-015365-iqdi99pd 2154 13 einer einer NNP cord-015365-iqdi99pd 2154 14 primären primären NNP cord-015365-iqdi99pd 2154 15 Nichtfunktion Nichtfunktion NNP cord-015365-iqdi99pd 2154 16 der der NNP cord-015365-iqdi99pd 2154 17 Leber Leber NNP cord-015365-iqdi99pd 2154 18 . . . cord-015365-iqdi99pd 2155 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2155 2 . . . cord-015365-iqdi99pd 2156 1 Die die VB cord-015365-iqdi99pd 2156 2 KLNT KLNT NNP cord-015365-iqdi99pd 2156 3 stellt stellt NNP cord-015365-iqdi99pd 2156 4 an an DT cord-015365-iqdi99pd 2156 5 unserem unserem JJ cord-015365-iqdi99pd 2156 6 Zentrum Zentrum NNP cord-015365-iqdi99pd 2156 7 eine eine NNP cord-015365-iqdi99pd 2156 8 gute gute NNP cord-015365-iqdi99pd 2156 9 Therapieoption Therapieoption NNP cord-015365-iqdi99pd 2156 10 bei bei NNP cord-015365-iqdi99pd 2156 11 terminaler terminaler NNP cord-015365-iqdi99pd 2156 12 Leber Leber NNP cord-015365-iqdi99pd 2156 13 - - HYPH cord-015365-iqdi99pd 2156 14 und und NNP cord-015365-iqdi99pd 2156 15 Nierenerkrankung Nierenerkrankung NNP cord-015365-iqdi99pd 2156 16 dar dar NNP cord-015365-iqdi99pd 2156 17 . . . cord-015365-iqdi99pd 2157 1 Laut Laut NNP cord-015365-iqdi99pd 2157 2 ELTR ELTR NNP cord-015365-iqdi99pd 2157 3 beträgt beträgt NN cord-015365-iqdi99pd 2157 4 die die VBP cord-015365-iqdi99pd 2157 5 1-und 1-und CD cord-015365-iqdi99pd 2157 6 5-Jahresüberlebensrate 5-Jahresüberlebensrate NNP cord-015365-iqdi99pd 2157 7 für für JJ cord-015365-iqdi99pd 2157 8 alleinige alleinige NNP cord-015365-iqdi99pd 2157 9 orthotope orthotope NNP cord-015365-iqdi99pd 2157 10 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2157 11 78 78 CD cord-015365-iqdi99pd 2157 12 % % NN cord-015365-iqdi99pd 2157 13 bzw bzw NNP cord-015365-iqdi99pd 2157 14 . . . cord-015365-iqdi99pd 2158 1 64 64 CD cord-015365-iqdi99pd 2158 2 % % NN cord-015365-iqdi99pd 2158 3 und und IN cord-015365-iqdi99pd 2158 4 ist ist NNP cord-015365-iqdi99pd 2158 5 daher daher NNP cord-015365-iqdi99pd 2158 6 mit mit NNP cord-015365-iqdi99pd 2158 7 unseren unseren NNP cord-015365-iqdi99pd 2158 8 Resultaten Resultaten NNP cord-015365-iqdi99pd 2158 9 vergleichbar vergleichbar NN cord-015365-iqdi99pd 2158 10 . . . cord-015365-iqdi99pd 2159 1 Die die VB cord-015365-iqdi99pd 2159 2 hohe hohe NNP cord-015365-iqdi99pd 2160 1 perioperative perioperative NNP cord-015365-iqdi99pd 2160 2 Mortalität Mortalität NNP cord-015365-iqdi99pd 2160 3 der der VBP cord-015365-iqdi99pd 2160 4 KLNT KLNT NNP cord-015365-iqdi99pd 2160 5 spricht spricht NNP cord-015365-iqdi99pd 2160 6 für für IN cord-015365-iqdi99pd 2160 7 ein ein NNP cord-015365-iqdi99pd 2160 8 rezent rezent NNP cord-015365-iqdi99pd 2160 9 diskutiertes diskutiertes NNP cord-015365-iqdi99pd 2160 10 zweizeitiges zweizeitiges NNP cord-015365-iqdi99pd 2160 11 Vorgehen Vorgehen NNP cord-015365-iqdi99pd 2160 12 , , , cord-015365-iqdi99pd 2160 13 um um UH cord-015365-iqdi99pd 2160 14 einen einen NNP cord-015365-iqdi99pd 2160 15 möglichen möglichen NNP cord-015365-iqdi99pd 2160 16 Organverlust Organverlust NNP cord-015365-iqdi99pd 2160 17 zu zu NNP cord-015365-iqdi99pd 2160 18 vermeiden vermeiden NNP cord-015365-iqdi99pd 2160 19 . . . cord-015365-iqdi99pd 2161 1 Orthotopic Orthotopic NNP cord-015365-iqdi99pd 2161 2 liver liver NN cord-015365-iqdi99pd 2161 3 transplantation transplantation NN cord-015365-iqdi99pd 2161 4 ( ( -LRB- cord-015365-iqdi99pd 2161 5 OLT OLT NNP cord-015365-iqdi99pd 2161 6 ) ) -RRB- cord-015365-iqdi99pd 2161 7 under under IN cord-015365-iqdi99pd 2161 8 the the DT cord-015365-iqdi99pd 2161 9 use use NN cord-015365-iqdi99pd 2161 10 of of IN cord-015365-iqdi99pd 2161 11 a a DT cord-015365-iqdi99pd 2161 12 protective protective JJ cord-015365-iqdi99pd 2161 13 filter filter NN cord-015365-iqdi99pd 2161 14 against against IN cord-015365-iqdi99pd 2161 15 phototoxicity phototoxicity NN cord-015365-iqdi99pd 2161 16 in in IN cord-015365-iqdi99pd 2161 17 a a DT cord-015365-iqdi99pd 2161 18 patient patient NN cord-015365-iqdi99pd 2161 19 suffering suffer VBG cord-015365-iqdi99pd 2161 20 from from IN cord-015365-iqdi99pd 2161 21 erythropoietic erythropoietic NNP cord-015365-iqdi99pd 2161 22 protoporphyria protoporphyria NNP cord-015365-iqdi99pd 2161 23 ( ( -LRB- cord-015365-iqdi99pd 2161 24 EPP EPP NNP cord-015365-iqdi99pd 2161 25 ) ) -RRB- cord-015365-iqdi99pd 2161 26 with with IN cord-015365-iqdi99pd 2161 27 liver liver NN cord-015365-iqdi99pd 2161 28 cirrhosis cirrhosis NN cord-015365-iqdi99pd 2161 29 Background Background NNP cord-015365-iqdi99pd 2161 30 . . . cord-015365-iqdi99pd 2162 1 Erythropoietic Erythropoietic NNP cord-015365-iqdi99pd 2162 2 protoporphyria protoporphyria NNP cord-015365-iqdi99pd 2162 3 ( ( -LRB- cord-015365-iqdi99pd 2162 4 EPP EPP NNP cord-015365-iqdi99pd 2162 5 ) ) -RRB- cord-015365-iqdi99pd 2162 6 is be VBZ cord-015365-iqdi99pd 2162 7 a a DT cord-015365-iqdi99pd 2162 8 rare rare JJ cord-015365-iqdi99pd 2162 9 condition condition NN cord-015365-iqdi99pd 2162 10 arising arise VBG cord-015365-iqdi99pd 2162 11 from from IN cord-015365-iqdi99pd 2162 12 a a DT cord-015365-iqdi99pd 2162 13 deficiency deficiency NN cord-015365-iqdi99pd 2162 14 in in IN cord-015365-iqdi99pd 2162 15 the the DT cord-015365-iqdi99pd 2162 16 enzyme enzyme NN cord-015365-iqdi99pd 2162 17 ferrochelatase ferrochelatase NN cord-015365-iqdi99pd 2162 18 , , , cord-015365-iqdi99pd 2162 19 leading lead VBG cord-015365-iqdi99pd 2162 20 to to IN cord-015365-iqdi99pd 2162 21 abnormally abnormally RB cord-015365-iqdi99pd 2162 22 high high JJ cord-015365-iqdi99pd 2162 23 levels level NNS cord-015365-iqdi99pd 2162 24 of of IN cord-015365-iqdi99pd 2162 25 protoporphyrin protoporphyrin NNP cord-015365-iqdi99pd 2162 26 in in IN cord-015365-iqdi99pd 2162 27 the the DT cord-015365-iqdi99pd 2162 28 tissue tissue NN cord-015365-iqdi99pd 2162 29 . . . cord-015365-iqdi99pd 2163 1 Apart apart RB cord-015365-iqdi99pd 2163 2 from from IN cord-015365-iqdi99pd 2163 3 increased increase VBN cord-015365-iqdi99pd 2163 4 photosensitivity photosensitivity NN cord-015365-iqdi99pd 2163 5 leading lead VBG cord-015365-iqdi99pd 2163 6 to to IN cord-015365-iqdi99pd 2163 7 acute acute JJ cord-015365-iqdi99pd 2163 8 and and CC cord-015365-iqdi99pd 2163 9 chronic chronic JJ cord-015365-iqdi99pd 2163 10 skin skin NN cord-015365-iqdi99pd 2163 11 changes change NNS cord-015365-iqdi99pd 2163 12 , , , cord-015365-iqdi99pd 2163 13 in in IN cord-015365-iqdi99pd 2163 14 a a DT cord-015365-iqdi99pd 2163 15 small small JJ cord-015365-iqdi99pd 2163 16 number number NN cord-015365-iqdi99pd 2163 17 of of IN cord-015365-iqdi99pd 2163 18 cases case NNS cord-015365-iqdi99pd 2163 19 protoporphyrin protoporphyrin NNP cord-015365-iqdi99pd 2163 20 deposits deposit NNS cord-015365-iqdi99pd 2163 21 and and CC cord-015365-iqdi99pd 2163 22 pigment pigment NN cord-015365-iqdi99pd 2163 23 loading loading NN cord-015365-iqdi99pd 2163 24 of of IN cord-015365-iqdi99pd 2163 25 the the DT cord-015365-iqdi99pd 2163 26 hepatocytes hepatocyte NNS cord-015365-iqdi99pd 2163 27 cause cause VBP cord-015365-iqdi99pd 2163 28 liver liver NN cord-015365-iqdi99pd 2163 29 cirrhosis cirrhosis NN cord-015365-iqdi99pd 2163 30 . . . cord-015365-iqdi99pd 2164 1 In in IN cord-015365-iqdi99pd 2164 2 these these DT cord-015365-iqdi99pd 2164 3 patients patient NNS cord-015365-iqdi99pd 2164 4 liver liver NN cord-015365-iqdi99pd 2164 5 transplantation transplantation NN cord-015365-iqdi99pd 2164 6 is be VBZ cord-015365-iqdi99pd 2164 7 the the DT cord-015365-iqdi99pd 2164 8 therapy therapy NN cord-015365-iqdi99pd 2164 9 of of IN cord-015365-iqdi99pd 2164 10 choice choice NN cord-015365-iqdi99pd 2164 11 . . . cord-015365-iqdi99pd 2165 1 Nevertheless nevertheless RB cord-015365-iqdi99pd 2165 2 intestinal intestinal JJ cord-015365-iqdi99pd 2165 3 ulceration ulceration NN cord-015365-iqdi99pd 2165 4 , , , cord-015365-iqdi99pd 2165 5 bleeding bleed VBG cord-015365-iqdi99pd 2165 6 and and CC cord-015365-iqdi99pd 2165 7 ultimately ultimately RB cord-015365-iqdi99pd 2165 8 multiorgan multiorgan NNP cord-015365-iqdi99pd 2165 9 failure failure NN cord-015365-iqdi99pd 2165 10 can can MD cord-015365-iqdi99pd 2165 11 occur occur VB cord-015365-iqdi99pd 2165 12 if if IN cord-015365-iqdi99pd 2165 13 no no DT cord-015365-iqdi99pd 2165 14 protective protective JJ cord-015365-iqdi99pd 2165 15 measures measure NNS cord-015365-iqdi99pd 2165 16 are be VBP cord-015365-iqdi99pd 2165 17 taken take VBN cord-015365-iqdi99pd 2165 18 against against IN cord-015365-iqdi99pd 2165 19 phototoxic phototoxic JJ cord-015365-iqdi99pd 2165 20 injury injury NN cord-015365-iqdi99pd 2165 21 during during IN cord-015365-iqdi99pd 2165 22 surgery surgery NN cord-015365-iqdi99pd 2165 23 . . . cord-015365-iqdi99pd 2166 1 Methods method NNS cord-015365-iqdi99pd 2166 2 and and CC cord-015365-iqdi99pd 2166 3 Results result NNS cord-015365-iqdi99pd 2166 4 . . . cord-015365-iqdi99pd 2167 1 We -PRON- PRP cord-015365-iqdi99pd 2167 2 would would MD cord-015365-iqdi99pd 2167 3 like like VB cord-015365-iqdi99pd 2167 4 to to TO cord-015365-iqdi99pd 2167 5 present present VB cord-015365-iqdi99pd 2167 6 the the DT cord-015365-iqdi99pd 2167 7 case case NN cord-015365-iqdi99pd 2167 8 of of IN cord-015365-iqdi99pd 2167 9 a a DT cord-015365-iqdi99pd 2167 10 36-year 36-year JJ cord-015365-iqdi99pd 2167 11 - - HYPH cord-015365-iqdi99pd 2167 12 old old JJ cord-015365-iqdi99pd 2167 13 patient patient NN cord-015365-iqdi99pd 2167 14 who who WP cord-015365-iqdi99pd 2167 15 was be VBD cord-015365-iqdi99pd 2167 16 admitted admit VBN cord-015365-iqdi99pd 2167 17 to to IN cord-015365-iqdi99pd 2167 18 our -PRON- PRP$ cord-015365-iqdi99pd 2167 19 department department NN cord-015365-iqdi99pd 2167 20 for for IN cord-015365-iqdi99pd 2167 21 liver liver NN cord-015365-iqdi99pd 2167 22 transplantation transplantation NN cord-015365-iqdi99pd 2167 23 . . . cord-015365-iqdi99pd 2168 1 EPP EPP NNP cord-015365-iqdi99pd 2168 2 had have VBD cord-015365-iqdi99pd 2168 3 been be VBN cord-015365-iqdi99pd 2168 4 diagnosed diagnose VBN cord-015365-iqdi99pd 2168 5 32 32 CD cord-015365-iqdi99pd 2168 6 years year NNS cord-015365-iqdi99pd 2168 7 ago ago RB cord-015365-iqdi99pd 2168 8 . . . cord-015365-iqdi99pd 2169 1 The the DT cord-015365-iqdi99pd 2169 2 patient patient NN cord-015365-iqdi99pd 2169 3 suffered suffer VBD cord-015365-iqdi99pd 2169 4 from from IN cord-015365-iqdi99pd 2169 5 typical typical JJ cord-015365-iqdi99pd 2169 6 skin skin NN cord-015365-iqdi99pd 2169 7 changes change NNS cord-015365-iqdi99pd 2169 8 and and CC cord-015365-iqdi99pd 2169 9 cholestatic cholestatic JJ cord-015365-iqdi99pd 2169 10 liver liver NN cord-015365-iqdi99pd 2169 11 cirrhosis cirrhosis NN cord-015365-iqdi99pd 2169 12 had have VBD cord-015365-iqdi99pd 2169 13 been be VBN cord-015365-iqdi99pd 2169 14 histologically histologically RB cord-015365-iqdi99pd 2169 15 confirmed confirm VBN cord-015365-iqdi99pd 2169 16 . . . cord-015365-iqdi99pd 2170 1 OLT OLT NNP cord-015365-iqdi99pd 2170 2 was be VBD cord-015365-iqdi99pd 2170 3 performed perform VBN cord-015365-iqdi99pd 2170 4 successfully successfully RB cord-015365-iqdi99pd 2170 5 using use VBG cord-015365-iqdi99pd 2170 6 protective protective JJ cord-015365-iqdi99pd 2170 7 measures measure NNS cord-015365-iqdi99pd 2170 8 to to TO cord-015365-iqdi99pd 2170 9 prevent prevent VB cord-015365-iqdi99pd 2170 10 phototoxic phototoxic JJ cord-015365-iqdi99pd 2170 11 injury injury NN cord-015365-iqdi99pd 2170 12 to to IN cord-015365-iqdi99pd 2170 13 the the DT cord-015365-iqdi99pd 2170 14 abdominal abdominal JJ cord-015365-iqdi99pd 2170 15 organs organ NNS cord-015365-iqdi99pd 2170 16 . . . cord-015365-iqdi99pd 2171 1 A a DT cord-015365-iqdi99pd 2171 2 flexible flexible JJ cord-015365-iqdi99pd 2171 3 yellow yellow JJ cord-015365-iqdi99pd 2171 4 filter filter NN cord-015365-iqdi99pd 2171 5 omitting omit VBG cord-015365-iqdi99pd 2171 6 wavelengths wavelength NNS cord-015365-iqdi99pd 2171 7 below below IN cord-015365-iqdi99pd 2171 8 470 470 CD cord-015365-iqdi99pd 2171 9 nm nm NN cord-015365-iqdi99pd 2171 10 was be VBD cord-015365-iqdi99pd 2171 11 applied apply VBN cord-015365-iqdi99pd 2171 12 to to IN cord-015365-iqdi99pd 2171 13 operating operate VBG cord-015365-iqdi99pd 2171 14 room room NN cord-015365-iqdi99pd 2171 15 luminaires luminaire NNS cord-015365-iqdi99pd 2171 16 to to TO cord-015365-iqdi99pd 2171 17 avoid avoid VB cord-015365-iqdi99pd 2171 18 phototoxic phototoxic JJ cord-015365-iqdi99pd 2171 19 injury injury NN cord-015365-iqdi99pd 2171 20 while while IN cord-015365-iqdi99pd 2171 21 maintaining maintain VBG cord-015365-iqdi99pd 2171 22 visual visual JJ cord-015365-iqdi99pd 2171 23 colour colour NN cord-015365-iqdi99pd 2171 24 perception perception NN cord-015365-iqdi99pd 2171 25 of of IN cord-015365-iqdi99pd 2171 26 the the DT cord-015365-iqdi99pd 2171 27 surgeons surgeon NNS cord-015365-iqdi99pd 2171 28 . . . cord-015365-iqdi99pd 2172 1 The the DT cord-015365-iqdi99pd 2172 2 immediate immediate JJ cord-015365-iqdi99pd 2172 3 postoperative postoperative JJ cord-015365-iqdi99pd 2172 4 period period NN cord-015365-iqdi99pd 2172 5 was be VBD cord-015365-iqdi99pd 2172 6 without without IN cord-015365-iqdi99pd 2172 7 any any DT cord-015365-iqdi99pd 2172 8 complications complication NNS cord-015365-iqdi99pd 2172 9 related relate VBN cord-015365-iqdi99pd 2172 10 to to IN cord-015365-iqdi99pd 2172 11 the the DT cord-015365-iqdi99pd 2172 12 EPP EPP NNP cord-015365-iqdi99pd 2172 13 . . . cord-015365-iqdi99pd 2173 1 Seven seven CD cord-015365-iqdi99pd 2173 2 months month NNS cord-015365-iqdi99pd 2173 3 after after IN cord-015365-iqdi99pd 2173 4 transplantation transplantation NN cord-015365-iqdi99pd 2173 5 the the DT cord-015365-iqdi99pd 2173 6 patient patient NN cord-015365-iqdi99pd 2173 7 is be VBZ cord-015365-iqdi99pd 2173 8 in in IN cord-015365-iqdi99pd 2173 9 good good JJ cord-015365-iqdi99pd 2173 10 general general JJ cord-015365-iqdi99pd 2173 11 health health NN cord-015365-iqdi99pd 2173 12 and and CC cord-015365-iqdi99pd 2173 13 liver liver NN cord-015365-iqdi99pd 2173 14 function function NN cord-015365-iqdi99pd 2173 15 tests test NNS cord-015365-iqdi99pd 2173 16 show show VBP cord-015365-iqdi99pd 2173 17 good good JJ cord-015365-iqdi99pd 2173 18 results result NNS cord-015365-iqdi99pd 2173 19 . . . cord-015365-iqdi99pd 2174 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2174 2 . . . cord-015365-iqdi99pd 2175 1 OLT OLT NNP cord-015365-iqdi99pd 2175 2 is be VBZ cord-015365-iqdi99pd 2175 3 a a DT cord-015365-iqdi99pd 2175 4 suitable suitable JJ cord-015365-iqdi99pd 2175 5 treatment treatment NN cord-015365-iqdi99pd 2175 6 for for IN cord-015365-iqdi99pd 2175 7 patients patient NNS cord-015365-iqdi99pd 2175 8 suffering suffer VBG cord-015365-iqdi99pd 2175 9 from from IN cord-015365-iqdi99pd 2175 10 EPP EPP NNP cord-015365-iqdi99pd 2175 11 with with IN cord-015365-iqdi99pd 2175 12 hepatic hepatic JJ cord-015365-iqdi99pd 2175 13 involvement involvement NN cord-015365-iqdi99pd 2175 14 and and CC cord-015365-iqdi99pd 2175 15 cholestatic cholestatic JJ cord-015365-iqdi99pd 2175 16 cirrhosis cirrhosis NN cord-015365-iqdi99pd 2175 17 if if IN cord-015365-iqdi99pd 2175 18 protective protective JJ cord-015365-iqdi99pd 2175 19 measures measure NNS cord-015365-iqdi99pd 2175 20 against against IN cord-015365-iqdi99pd 2175 21 phototoxic phototoxic JJ cord-015365-iqdi99pd 2175 22 injuries injury NNS cord-015365-iqdi99pd 2175 23 are be VBP cord-015365-iqdi99pd 2175 24 used use VBN cord-015365-iqdi99pd 2175 25 during during IN cord-015365-iqdi99pd 2175 26 surgery surgery NN cord-015365-iqdi99pd 2175 27 . . . cord-015365-iqdi99pd 2176 1 Günstige Günstige NNP cord-015365-iqdi99pd 2176 2 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2176 3 nach nach NNP cord-015365-iqdi99pd 2176 4 schweren schweren NNP cord-015365-iqdi99pd 2176 5 immunologischen immunologischen NNP cord-015365-iqdi99pd 2176 6 und und NNP cord-015365-iqdi99pd 2176 7 infektiösen infektiösen NNP cord-015365-iqdi99pd 2177 1 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 2177 2 nach nach NNP cord-015365-iqdi99pd 2177 3 Dünndarm Dünndarm NNP cord-015365-iqdi99pd 2177 4 - - HYPH cord-015365-iqdi99pd 2177 5 Transplantation Transplantation NNP cord-015365-iqdi99pd 2177 6 : : : cord-015365-iqdi99pd 2177 7 ein ein NNP cord-015365-iqdi99pd 2177 8 Fallbericht Fallbericht NNP cord-015365-iqdi99pd 2177 9 C. C. NNP cord-015365-iqdi99pd 2177 10 Bösmüller Bösmüller NNP cord-015365-iqdi99pd 2177 11 1 1 CD cord-015365-iqdi99pd 2177 12 , , , cord-015365-iqdi99pd 2177 13 A. A. NNP cord-015365-iqdi99pd 2177 14 Weißenbacher Weißenbacher NNP cord-015365-iqdi99pd 2177 15 1 1 CD cord-015365-iqdi99pd 2177 16 , , , cord-015365-iqdi99pd 2177 17 M. M. NNP cord-015365-iqdi99pd 2177 18 Biebl Biebl NNP cord-015365-iqdi99pd 2177 19 1 1 CD cord-015365-iqdi99pd 2177 20 , , , cord-015365-iqdi99pd 2177 21 R. R. NNP cord-015365-iqdi99pd 2177 22 Öllinger Öllinger NNP cord-015365-iqdi99pd 2177 23 1 1 CD cord-015365-iqdi99pd 2177 24 , , , cord-015365-iqdi99pd 2177 25 S. S. NNP cord-015365-iqdi99pd 2177 26 Schneeberger Schneeberger NNP cord-015365-iqdi99pd 2177 27 1 1 CD cord-015365-iqdi99pd 2177 28 , , , cord-015365-iqdi99pd 2177 29 F. F. NNP cord-015365-iqdi99pd 2177 30 Aigner Aigner NNP cord-015365-iqdi99pd 2177 31 1 1 CD cord-015365-iqdi99pd 2178 1 , , , cord-015365-iqdi99pd 2178 2 S. S. NNP cord-015365-iqdi99pd 2178 3 Weiß Weiß NNP cord-015365-iqdi99pd 2178 4 1 1 CD cord-015365-iqdi99pd 2178 5 , , , cord-015365-iqdi99pd 2178 6 R. R. NNP cord-015365-iqdi99pd 2178 7 Oberhuber Oberhuber NNP cord-015365-iqdi99pd 2178 8 1 1 CD cord-015365-iqdi99pd 2178 9 , , , cord-015365-iqdi99pd 2178 10 C. C. NNP cord-015365-iqdi99pd 2178 11 Ensinger Ensinger NNP cord-015365-iqdi99pd 2178 12 2 2 CD cord-015365-iqdi99pd 2178 13 , , , cord-015365-iqdi99pd 2178 14 J. J. NNP cord-015365-iqdi99pd 2178 15 Pratschke Pratschke NNP cord-015365-iqdi99pd 2178 16 1 1 CD cord-015365-iqdi99pd 2178 17 uneventful uneventful JJ cord-015365-iqdi99pd 2178 18 course course NN cord-015365-iqdi99pd 2178 19 after after IN cord-015365-iqdi99pd 2178 20 transplantation transplantation NN cord-015365-iqdi99pd 2178 21 with with IN cord-015365-iqdi99pd 2178 22 only only RB cord-015365-iqdi99pd 2178 23 three three CD cord-015365-iqdi99pd 2178 24 mild mild JJ cord-015365-iqdi99pd 2178 25 acute acute JJ cord-015365-iqdi99pd 2178 26 rejection rejection NN cord-015365-iqdi99pd 2178 27 episodes episode NNS cord-015365-iqdi99pd 2178 28 within within IN cord-015365-iqdi99pd 2178 29 11 11 CD cord-015365-iqdi99pd 2178 30 years year NNS cord-015365-iqdi99pd 2178 31 . . . cord-015365-iqdi99pd 2179 1 Due due IN cord-015365-iqdi99pd 2179 2 to to IN cord-015365-iqdi99pd 2179 3 a a DT cord-015365-iqdi99pd 2179 4 fracture fracture NN cord-015365-iqdi99pd 2179 5 of of IN cord-015365-iqdi99pd 2179 6 the the DT cord-015365-iqdi99pd 2179 7 right right JJ cord-015365-iqdi99pd 2179 8 allograft allograft NN cord-015365-iqdi99pd 2179 9 radius radius NN cord-015365-iqdi99pd 2179 10 requiring require VBG cord-015365-iqdi99pd 2179 11 surgery surgery NN cord-015365-iqdi99pd 2179 12 at at IN cord-015365-iqdi99pd 2179 13 10.5 10.5 CD cord-015365-iqdi99pd 2179 14 years year NNS cord-015365-iqdi99pd 2179 15 posttransplant posttransplant NN cord-015365-iqdi99pd 2179 16 immunosuppression immunosuppression NN cord-015365-iqdi99pd 2179 17 ( ( -LRB- cord-015365-iqdi99pd 2179 18 IS is NN cord-015365-iqdi99pd 2179 19 ) ) -RRB- cord-015365-iqdi99pd 2179 20 was be VBD cord-015365-iqdi99pd 2179 21 switched switch VBN cord-015365-iqdi99pd 2179 22 from from IN cord-015365-iqdi99pd 2179 23 sirolimusmonotherapy sirolimusmonotherapy NNP cord-015365-iqdi99pd 2179 24 to to IN cord-015365-iqdi99pd 2179 25 prednisone prednisone NNP cord-015365-iqdi99pd 2179 26 . . . cord-015365-iqdi99pd 2180 1 One one CD cord-015365-iqdi99pd 2180 2 month month NN cord-015365-iqdi99pd 2180 3 thereafter thereafter RB cord-015365-iqdi99pd 2180 4 the the DT cord-015365-iqdi99pd 2180 5 patient patient NN cord-015365-iqdi99pd 2180 6 experienced experience VBD cord-015365-iqdi99pd 2180 7 metabolic metabolic JJ cord-015365-iqdi99pd 2180 8 deterioration deterioration NN cord-015365-iqdi99pd 2180 9 ( ( -LRB- cord-015365-iqdi99pd 2180 10 hypothyroidism hypothyroidism NN cord-015365-iqdi99pd 2180 11 , , , cord-015365-iqdi99pd 2180 12 hyperlipidemia hyperlipidemia NN cord-015365-iqdi99pd 2180 13 and and CC cord-015365-iqdi99pd 2180 14 hyperglycemia hyperglycemia NN cord-015365-iqdi99pd 2180 15 ) ) -RRB- cord-015365-iqdi99pd 2180 16 and and CC cord-015365-iqdi99pd 2180 17 developed develop VBD cord-015365-iqdi99pd 2180 18 an an DT cord-015365-iqdi99pd 2180 19 exanthema exanthema NN cord-015365-iqdi99pd 2180 20 and and CC cord-015365-iqdi99pd 2180 21 pruritus pruritus NN cord-015365-iqdi99pd 2180 22 on on IN cord-015365-iqdi99pd 2180 23 the the DT cord-015365-iqdi99pd 2180 24 trunk trunk NN cord-015365-iqdi99pd 2180 25 and and CC cord-015365-iqdi99pd 2180 26 the the DT cord-015365-iqdi99pd 2180 27 upper upper JJ cord-015365-iqdi99pd 2180 28 extremities extremity NNS cord-015365-iqdi99pd 2180 29 , , , cord-015365-iqdi99pd 2180 30 including include VBG cord-015365-iqdi99pd 2180 31 both both CC cord-015365-iqdi99pd 2180 32 the the DT cord-015365-iqdi99pd 2180 33 recipient recipient NN cord-015365-iqdi99pd 2180 34 's 's POS cord-015365-iqdi99pd 2180 35 own own JJ cord-015365-iqdi99pd 2180 36 skin skin NN cord-015365-iqdi99pd 2180 37 and and CC cord-015365-iqdi99pd 2180 38 the the DT cord-015365-iqdi99pd 2180 39 allograft allograft NN cord-015365-iqdi99pd 2180 40 skin skin NN cord-015365-iqdi99pd 2180 41 . . . cord-015365-iqdi99pd 2181 1 BP BP NNP cord-015365-iqdi99pd 2181 2 was be VBD cord-015365-iqdi99pd 2181 3 diagnosed diagnose VBN cord-015365-iqdi99pd 2181 4 upon upon IN cord-015365-iqdi99pd 2181 5 direct direct JJ cord-015365-iqdi99pd 2181 6 immunofluorescence immunofluorescence NN cord-015365-iqdi99pd 2181 7 of of IN cord-015365-iqdi99pd 2181 8 skin skin NN cord-015365-iqdi99pd 2181 9 biopsies biopsy NNS cord-015365-iqdi99pd 2181 10 ( ( -LRB- cord-015365-iqdi99pd 2181 11 linear linear NNP cord-015365-iqdi99pd 2181 12 C3 C3 NNP cord-015365-iqdi99pd 2181 13 and and CC cord-015365-iqdi99pd 2181 14 IgG igg NN cord-015365-iqdi99pd 2181 15 deposits deposit NNS cord-015365-iqdi99pd 2181 16 along along IN cord-015365-iqdi99pd 2181 17 the the DT cord-015365-iqdi99pd 2181 18 basement basement NN cord-015365-iqdi99pd 2181 19 membrane membrane NN cord-015365-iqdi99pd 2181 20 zone zone NN cord-015365-iqdi99pd 2181 21 ) ) -RRB- cord-015365-iqdi99pd 2181 22 and and CC cord-015365-iqdi99pd 2181 23 detection detection NN cord-015365-iqdi99pd 2181 24 of of IN cord-015365-iqdi99pd 2181 25 serum serum NN cord-015365-iqdi99pd 2181 26 autoantibodies autoantibody NNS cord-015365-iqdi99pd 2181 27 against against IN cord-015365-iqdi99pd 2181 28 the the DT cord-015365-iqdi99pd 2181 29 BP BP NNP cord-015365-iqdi99pd 2181 30 antigen antigen NN cord-015365-iqdi99pd 2181 31 2 2 CD cord-015365-iqdi99pd 2182 1 ( ( -LRB- cord-015365-iqdi99pd 2182 2 BP180nc16a bp180nc16a NN cord-015365-iqdi99pd 2182 3 : : : cord-015365-iqdi99pd 2182 4 142 142 CD cord-015365-iqdi99pd 2182 5 U u NN cord-015365-iqdi99pd 2182 6 / / SYM cord-015365-iqdi99pd 2182 7 l l NN cord-015365-iqdi99pd 2182 8 ) ) -RRB- cord-015365-iqdi99pd 2182 9 . . . cord-015365-iqdi99pd 2183 1 Histology histology NN cord-015365-iqdi99pd 2183 2 showed show VBD cord-015365-iqdi99pd 2183 3 a a DT cord-015365-iqdi99pd 2183 4 partial partial JJ cord-015365-iqdi99pd 2183 5 separation separation NN cord-015365-iqdi99pd 2183 6 along along IN cord-015365-iqdi99pd 2183 7 the the DT cord-015365-iqdi99pd 2183 8 dermalepidermal dermalepidermal JJ cord-015365-iqdi99pd 2183 9 junction junction NN cord-015365-iqdi99pd 2183 10 and and CC cord-015365-iqdi99pd 2183 11 a a DT cord-015365-iqdi99pd 2183 12 mild mild JJ cord-015365-iqdi99pd 2183 13 perivascular perivascular JJ cord-015365-iqdi99pd 2183 14 infiltration infiltration NN cord-015365-iqdi99pd 2183 15 consisting consist VBG cord-015365-iqdi99pd 2183 16 of of IN cord-015365-iqdi99pd 2183 17 lymphocytes lymphocyte NNS cord-015365-iqdi99pd 2183 18 , , , cord-015365-iqdi99pd 2183 19 eosinophils eosinophil NNS cord-015365-iqdi99pd 2183 20 and and CC cord-015365-iqdi99pd 2183 21 granulocytes granulocyte NNS cord-015365-iqdi99pd 2183 22 . . . cord-015365-iqdi99pd 2184 1 Cell cell NN cord-015365-iqdi99pd 2184 2 counts count NNS cord-015365-iqdi99pd 2184 3 were be VBD cord-015365-iqdi99pd 2184 4 within within IN cord-015365-iqdi99pd 2184 5 normal normal JJ cord-015365-iqdi99pd 2184 6 range range NN cord-015365-iqdi99pd 2184 7 . . . cord-015365-iqdi99pd 2185 1 No no DT cord-015365-iqdi99pd 2185 2 donor donor NN cord-015365-iqdi99pd 2185 3 specific specific JJ cord-015365-iqdi99pd 2185 4 antibodies antibody NNS cord-015365-iqdi99pd 2185 5 were be VBD cord-015365-iqdi99pd 2185 6 detected detect VBN cord-015365-iqdi99pd 2185 7 . . . cord-015365-iqdi99pd 2186 1 Skin skin NN cord-015365-iqdi99pd 2186 2 lesions lesion NNS cord-015365-iqdi99pd 2186 3 disappeared disappear VBD cord-015365-iqdi99pd 2186 4 under under IN cord-015365-iqdi99pd 2186 5 intensified intensify VBN cord-015365-iqdi99pd 2186 6 therapy therapy NN cord-015365-iqdi99pd 2186 7 with with IN cord-015365-iqdi99pd 2186 8 prednisone prednisone NNP cord-015365-iqdi99pd 2186 9 . . . cord-015365-iqdi99pd 2187 1 While while IN cord-015365-iqdi99pd 2187 2 conversion conversion NN cord-015365-iqdi99pd 2187 3 of of IN cord-015365-iqdi99pd 2187 4 IS is NN cord-015365-iqdi99pd 2187 5 and and CC cord-015365-iqdi99pd 2187 6 metabolic metabolic JJ cord-015365-iqdi99pd 2187 7 deterioration deterioration NN cord-015365-iqdi99pd 2187 8 might may MD cord-015365-iqdi99pd 2187 9 have have VB cord-015365-iqdi99pd 2187 10 contributed contribute VBN cord-015365-iqdi99pd 2187 11 to to IN cord-015365-iqdi99pd 2187 12 development development NN cord-015365-iqdi99pd 2187 13 of of IN cord-015365-iqdi99pd 2187 14 BP BP NNP cord-015365-iqdi99pd 2187 15 after after IN cord-015365-iqdi99pd 2187 16 hand hand NN cord-015365-iqdi99pd 2187 17 transplantation transplantation NN cord-015365-iqdi99pd 2187 18 , , , cord-015365-iqdi99pd 2187 19 the the DT cord-015365-iqdi99pd 2187 20 pathomechanism pathomechanism NN cord-015365-iqdi99pd 2187 21 remains remain VBZ cord-015365-iqdi99pd 2187 22 unclear unclear JJ cord-015365-iqdi99pd 2187 23 . . . cord-015365-iqdi99pd 2188 1 Belatacept belatacept NN cord-015365-iqdi99pd 2188 2 treatment treatment NN cord-015365-iqdi99pd 2188 3 for for IN cord-015365-iqdi99pd 2188 4 2 2 CD cord-015365-iqdi99pd 2188 5 years year NNS cord-015365-iqdi99pd 2188 6 after after IN cord-015365-iqdi99pd 2188 7 liver liver NN cord-015365-iqdi99pd 2188 8 transplantation transplantation NN cord-015365-iqdi99pd 2188 9 is be VBZ cord-015365-iqdi99pd 2188 10 not not RB cord-015365-iqdi99pd 2188 11 associated associate VBN cord-015365-iqdi99pd 2188 12 with with IN cord-015365-iqdi99pd 2188 13 overt overt JJ cord-015365-iqdi99pd 2188 14 immunomodulation immunomodulation NN cord-015365-iqdi99pd 2188 15 Background Background NNP cord-015365-iqdi99pd 2188 16 . . . cord-015365-iqdi99pd 2189 1 Belatacept Belatacept NNP cord-015365-iqdi99pd 2189 2 is be VBZ cord-015365-iqdi99pd 2189 3 a a DT cord-015365-iqdi99pd 2189 4 costimulation costimulation NN cord-015365-iqdi99pd 2189 5 blocker blocker NN cord-015365-iqdi99pd 2189 6 with with IN cord-015365-iqdi99pd 2189 7 immunomodulatory immunomodulatory JJ cord-015365-iqdi99pd 2189 8 properties property NNS cord-015365-iqdi99pd 2189 9 in in IN cord-015365-iqdi99pd 2189 10 the the DT cord-015365-iqdi99pd 2189 11 experimental experimental JJ cord-015365-iqdi99pd 2189 12 setting setting NN cord-015365-iqdi99pd 2189 13 . . . cord-015365-iqdi99pd 2190 1 Moreover moreover RB cord-015365-iqdi99pd 2190 2 , , , cord-015365-iqdi99pd 2190 3 the the DT cord-015365-iqdi99pd 2190 4 liver liver NN cord-015365-iqdi99pd 2190 5 graft graft NN cord-015365-iqdi99pd 2190 6 itself -PRON- PRP cord-015365-iqdi99pd 2190 7 has have VBZ cord-015365-iqdi99pd 2190 8 been be VBN cord-015365-iqdi99pd 2190 9 claimed claim VBN cord-015365-iqdi99pd 2190 10 to to TO cord-015365-iqdi99pd 2190 11 have have VB cord-015365-iqdi99pd 2190 12 ' ' `` cord-015365-iqdi99pd 2190 13 tolerogenic tolerogenic JJ cord-015365-iqdi99pd 2190 14 ' ' '' cord-015365-iqdi99pd 2190 15 properties property NNS cord-015365-iqdi99pd 2190 16 . . . cord-015365-iqdi99pd 2191 1 The the DT cord-015365-iqdi99pd 2191 2 belatacept belatacept NN cord-015365-iqdi99pd 2191 3 multi multi JJ cord-015365-iqdi99pd 2191 4 - - JJ cord-015365-iqdi99pd 2191 5 center center JJ cord-015365-iqdi99pd 2191 6 phase phase NN cord-015365-iqdi99pd 2191 7 II ii CD cord-015365-iqdi99pd 2191 8 liver liver NN cord-015365-iqdi99pd 2191 9 transplantation transplantation NN cord-015365-iqdi99pd 2191 10 trial trial NN cord-015365-iqdi99pd 2191 11 was be VBD cord-015365-iqdi99pd 2191 12 terminated terminate VBN cord-015365-iqdi99pd 2191 13 during during IN cord-015365-iqdi99pd 2191 14 the the DT cord-015365-iqdi99pd 2191 15 long long JJ cord-015365-iqdi99pd 2191 16 - - HYPH cord-015365-iqdi99pd 2191 17 term term NN cord-015365-iqdi99pd 2191 18 extension extension NN cord-015365-iqdi99pd 2191 19 period period NN cord-015365-iqdi99pd 2191 20 on on IN cord-015365-iqdi99pd 2191 21 the the DT cord-015365-iqdi99pd 2191 22 recommendation recommendation NN cord-015365-iqdi99pd 2191 23 of of IN cord-015365-iqdi99pd 2191 24 the the DT cord-015365-iqdi99pd 2191 25 Data Data NNP cord-015365-iqdi99pd 2191 26 Monitoring Monitoring NNP cord-015365-iqdi99pd 2191 27 Committee Committee NNP cord-015365-iqdi99pd 2191 28 . . . cord-015365-iqdi99pd 2192 1 This this DT cord-015365-iqdi99pd 2192 2 situation situation NN cord-015365-iqdi99pd 2192 3 gave give VBD cord-015365-iqdi99pd 2192 4 us -PRON- PRP cord-015365-iqdi99pd 2192 5 the the DT cord-015365-iqdi99pd 2192 6 unique unique JJ cord-015365-iqdi99pd 2192 7 opportunity opportunity NN cord-015365-iqdi99pd 2192 8 to to TO cord-015365-iqdi99pd 2192 9 evaluate evaluate VB cord-015365-iqdi99pd 2192 10 the the DT cord-015365-iqdi99pd 2192 11 minimum minimum JJ cord-015365-iqdi99pd 2192 12 immunosuppression immunosuppression NN cord-015365-iqdi99pd 2192 13 required require VBN cord-015365-iqdi99pd 2192 14 in in IN cord-015365-iqdi99pd 2192 15 liver liver NN cord-015365-iqdi99pd 2192 16 transplant transplant NN cord-015365-iqdi99pd 2192 17 recipients recipient NNS cord-015365-iqdi99pd 2192 18 after after IN cord-015365-iqdi99pd 2192 19 > > XX cord-015365-iqdi99pd 2192 20 2 2 CD cord-015365-iqdi99pd 2192 21 years year NNS cord-015365-iqdi99pd 2192 22 of of IN cord-015365-iqdi99pd 2192 23 treatment treatment NN cord-015365-iqdi99pd 2192 24 with with IN cord-015365-iqdi99pd 2192 25 belatacept belatacept NN cord-015365-iqdi99pd 2192 26 . . . cord-015365-iqdi99pd 2193 1 Methods method NNS cord-015365-iqdi99pd 2193 2 . . . cord-015365-iqdi99pd 2194 1 In in IN cord-015365-iqdi99pd 2194 2 our -PRON- PRP$ cord-015365-iqdi99pd 2194 3 center center NN cord-015365-iqdi99pd 2194 4 all all DT cord-015365-iqdi99pd 2194 5 belatacept belatacept NN cord-015365-iqdi99pd 2194 6 patients patient NNS cord-015365-iqdi99pd 2194 7 ( ( -LRB- cord-015365-iqdi99pd 2194 8 n n CC cord-015365-iqdi99pd 2194 9 ¼ ¼ NNP cord-015365-iqdi99pd 2194 10 4 4 CD cord-015365-iqdi99pd 2194 11 ) ) -RRB- cord-015365-iqdi99pd 2194 12 were be VBD cord-015365-iqdi99pd 2194 13 switched switch VBN cord-015365-iqdi99pd 2194 14 to to IN cord-015365-iqdi99pd 2194 15 MMF MMF NNP cord-015365-iqdi99pd 2194 16 monotherapy monotherapy JJ cord-015365-iqdi99pd 2195 1 ( ( -LRB- cord-015365-iqdi99pd 2195 2 2Â1 2â1 CD cord-015365-iqdi99pd 2195 3 g g NN cord-015365-iqdi99pd 2195 4 / / SYM cord-015365-iqdi99pd 2195 5 day day NN cord-015365-iqdi99pd 2195 6 ) ) -RRB- cord-015365-iqdi99pd 2195 7 after after IN cord-015365-iqdi99pd 2195 8 discontinuation discontinuation NN cord-015365-iqdi99pd 2195 9 of of IN cord-015365-iqdi99pd 2195 10 belatacept belatacept NN cord-015365-iqdi99pd 2195 11 . . . cord-015365-iqdi99pd 2196 1 We -PRON- PRP cord-015365-iqdi99pd 2196 2 prospectively prospectively RB cord-015365-iqdi99pd 2196 3 assessed assess VBD cord-015365-iqdi99pd 2196 4 the the DT cord-015365-iqdi99pd 2196 5 occurrence occurrence NN cord-015365-iqdi99pd 2196 6 of of IN cord-015365-iqdi99pd 2196 7 acute acute JJ cord-015365-iqdi99pd 2196 8 rejection rejection NN cord-015365-iqdi99pd 2196 9 and and CC cord-015365-iqdi99pd 2196 10 evaluated evaluate VBN cord-015365-iqdi99pd 2196 11 kidney kidney NN cord-015365-iqdi99pd 2196 12 function function NN cord-015365-iqdi99pd 2196 13 ( ( -LRB- cord-015365-iqdi99pd 2196 14 calculated calculate VBN cord-015365-iqdi99pd 2196 15 GFR GFR NNP cord-015365-iqdi99pd 2196 16 ; ; : cord-015365-iqdi99pd 2196 17 MDRD MDRD NNP cord-015365-iqdi99pd 2196 18 ) ) -RRB- cord-015365-iqdi99pd 2196 19 over over IN cord-015365-iqdi99pd 2196 20 time time NN cord-015365-iqdi99pd 2196 21 in in IN cord-015365-iqdi99pd 2196 22 comparison comparison NN cord-015365-iqdi99pd 2196 23 to to IN cord-015365-iqdi99pd 2196 24 tacrolimus tacrolimus NN cord-015365-iqdi99pd 2196 25 - - HYPH cord-015365-iqdi99pd 2196 26 treated treat VBN cord-015365-iqdi99pd 2196 27 patients patient NNS cord-015365-iqdi99pd 2196 28 enrolled enrol VBN cord-015365-iqdi99pd 2196 29 in in IN cord-015365-iqdi99pd 2196 30 the the DT cord-015365-iqdi99pd 2196 31 control control NN cord-015365-iqdi99pd 2196 32 groups group NNS cord-015365-iqdi99pd 2196 33 of of IN cord-015365-iqdi99pd 2196 34 the the DT cord-015365-iqdi99pd 2196 35 multi multi JJ cord-015365-iqdi99pd 2196 36 - - JJ cord-015365-iqdi99pd 2196 37 center center JJ cord-015365-iqdi99pd 2196 38 trial trial NN cord-015365-iqdi99pd 2196 39 ( ( -LRB- cord-015365-iqdi99pd 2196 40 n n NN cord-015365-iqdi99pd 2196 41 ¼ ¼ NNP cord-015365-iqdi99pd 2196 42 4 4 CD cord-015365-iqdi99pd 2196 43 ) ) -RRB- cord-015365-iqdi99pd 2196 44 . . . cord-015365-iqdi99pd 2197 1 Results result NNS cord-015365-iqdi99pd 2197 2 . . . cord-015365-iqdi99pd 2198 1 The the DT cord-015365-iqdi99pd 2198 2 mean mean JJ cord-015365-iqdi99pd 2198 3 period period NN cord-015365-iqdi99pd 2198 4 from from IN cord-015365-iqdi99pd 2198 5 transplantation transplantation NN cord-015365-iqdi99pd 2198 6 to to IN cord-015365-iqdi99pd 2198 7 withdrawal withdrawal NN cord-015365-iqdi99pd 2198 8 of of IN cord-015365-iqdi99pd 2198 9 belatacept belatacept NN cord-015365-iqdi99pd 2198 10 was be VBD cord-015365-iqdi99pd 2198 11 30 30 CD cord-015365-iqdi99pd 2198 12 months month NNS cord-015365-iqdi99pd 2199 1 ( ( -LRB- cord-015365-iqdi99pd 2199 2 range range VBP cord-015365-iqdi99pd 2199 3 25 25 CD cord-015365-iqdi99pd 2199 4 - - SYM cord-015365-iqdi99pd 2199 5 35 35 CD cord-015365-iqdi99pd 2199 6 ) ) -RRB- cord-015365-iqdi99pd 2199 7 . . . cord-015365-iqdi99pd 2200 1 GFR GFR NNP cord-015365-iqdi99pd 2200 2 at at IN cord-015365-iqdi99pd 2200 3 the the DT cord-015365-iqdi99pd 2200 4 time time NN cord-015365-iqdi99pd 2200 5 of of IN cord-015365-iqdi99pd 2200 6 withdrawal withdrawal NN cord-015365-iqdi99pd 2200 7 was be VBD cord-015365-iqdi99pd 2200 8 more more JJR cord-015365-iqdi99pd 2200 9 than than IN cord-015365-iqdi99pd 2200 10 60 60 CD cord-015365-iqdi99pd 2200 11 ml/ ml/ JJ cord-015365-iqdi99pd 2201 1 min/1.73 min/1.73 NNP cord-015365-iqdi99pd 2201 2 m m CD cord-015365-iqdi99pd 2201 3 2 2 CD cord-015365-iqdi99pd 2201 4 in in IN cord-015365-iqdi99pd 2201 5 the the DT cord-015365-iqdi99pd 2201 6 belatacept belatacept NN cord-015365-iqdi99pd 2201 7 group group NN cord-015365-iqdi99pd 2202 1 ( ( -LRB- cord-015365-iqdi99pd 2202 2 4/4 4/4 CD cord-015365-iqdi99pd 2202 3 ; ; : cord-015365-iqdi99pd 2202 4 mean mean VB cord-015365-iqdi99pd 2202 5 : : : cord-015365-iqdi99pd 2202 6 101 101 CD cord-015365-iqdi99pd 2202 7 ml ml XX cord-015365-iqdi99pd 2202 8 [ [ -LRB- cord-015365-iqdi99pd 2202 9 range range NN cord-015365-iqdi99pd 2202 10 89 89 CD cord-015365-iqdi99pd 2202 11 - - SYM cord-015365-iqdi99pd 2202 12 114 114 CD cord-015365-iqdi99pd 2202 13 ] ] -RRB- cord-015365-iqdi99pd 2202 14 ) ) -RRB- cord-015365-iqdi99pd 2202 15 , , , cord-015365-iqdi99pd 2202 16 whereas whereas IN cord-015365-iqdi99pd 2202 17 3 3 CD cord-015365-iqdi99pd 2202 18 out out IN cord-015365-iqdi99pd 2202 19 of of IN cord-015365-iqdi99pd 2202 20 4 4 CD cord-015365-iqdi99pd 2202 21 patients patient NNS cord-015365-iqdi99pd 2202 22 in in IN cord-015365-iqdi99pd 2202 23 the the DT cord-015365-iqdi99pd 2202 24 control control NN cord-015365-iqdi99pd 2202 25 group group NN cord-015365-iqdi99pd 2202 26 had have VBD cord-015365-iqdi99pd 2202 27 a a DT cord-015365-iqdi99pd 2202 28 GFR GFR NNP cord-015365-iqdi99pd 2202 29 below below IN cord-015365-iqdi99pd 2202 30 60 60 CD cord-015365-iqdi99pd 2202 31 ml ml NNS cord-015365-iqdi99pd 2202 32 / / SYM cord-015365-iqdi99pd 2202 33 min/ min/ NN cord-015365-iqdi99pd 2202 34 1.73 1.73 CD cord-015365-iqdi99pd 2202 35 m m NN cord-015365-iqdi99pd 2202 36 2 2 CD cord-015365-iqdi99pd 2202 37 with with IN cord-015365-iqdi99pd 2202 38 a a DT cord-015365-iqdi99pd 2202 39 mean mean NN cord-015365-iqdi99pd 2202 40 of of IN cord-015365-iqdi99pd 2202 41 57.92 57.92 CD cord-015365-iqdi99pd 2202 42 ml ml NN cord-015365-iqdi99pd 2202 43 / / SYM cord-015365-iqdi99pd 2202 44 min/1.73 min/1.73 JJ cord-015365-iqdi99pd 2202 45 m m CD cord-015365-iqdi99pd 2202 46 2 2 CD cord-015365-iqdi99pd 2202 47 ( ( -LRB- cord-015365-iqdi99pd 2202 48 range range VBP cord-015365-iqdi99pd 2202 49 36 36 CD cord-015365-iqdi99pd 2202 50 - - SYM cord-015365-iqdi99pd 2202 51 98 98 CD cord-015365-iqdi99pd 2202 52 ) ) -RRB- cord-015365-iqdi99pd 2203 1 ( ( -LRB- cord-015365-iqdi99pd 2203 2 p p NN cord-015365-iqdi99pd 2203 3 ¼ ¼ CD cord-015365-iqdi99pd 2203 4 0.026 0.026 CD cord-015365-iqdi99pd 2203 5 ) ) -RRB- cord-015365-iqdi99pd 2203 6 . . . cord-015365-iqdi99pd 2204 1 Five five CD cord-015365-iqdi99pd 2204 2 months month NNS cord-015365-iqdi99pd 2204 3 after after IN cord-015365-iqdi99pd 2204 4 belatacept belatacept NN cord-015365-iqdi99pd 2204 5 discontinuation discontinuation NN cord-015365-iqdi99pd 2204 6 kidney kidney NN cord-015365-iqdi99pd 2204 7 function function NN cord-015365-iqdi99pd 2204 8 declined decline VBD cord-015365-iqdi99pd 2204 9 on on IN cord-015365-iqdi99pd 2204 10 average average JJ cord-015365-iqdi99pd 2204 11 by by IN cord-015365-iqdi99pd 2204 12 19.22 19.22 CD cord-015365-iqdi99pd 2204 13 ml ml NN cord-015365-iqdi99pd 2204 14 ( ( -LRB- cord-015365-iqdi99pd 2204 15 range range VB cord-015365-iqdi99pd 2204 16 À45 À45 NNP cord-015365-iqdi99pd 2204 17 to to IN cord-015365-iqdi99pd 2204 18 þ3,5 þ3,5 NNP cord-015365-iqdi99pd 2204 19 ) ) -RRB- cord-015365-iqdi99pd 2204 20 ( ( -LRB- cord-015365-iqdi99pd 2204 21 follow follow VB cord-015365-iqdi99pd 2204 22 - - HYPH cord-015365-iqdi99pd 2204 23 up up NN cord-015365-iqdi99pd 2204 24 ongoing ongoing JJ cord-015365-iqdi99pd 2204 25 ) ) -RRB- cord-015365-iqdi99pd 2204 26 . . . cord-015365-iqdi99pd 2205 1 After after IN cord-015365-iqdi99pd 2205 2 belatacept belatacept NN cord-015365-iqdi99pd 2205 3 withdrawal withdrawal NN cord-015365-iqdi99pd 2205 4 all all DT cord-015365-iqdi99pd 2205 5 4 4 CD cord-015365-iqdi99pd 2205 6 patients patient NNS cord-015365-iqdi99pd 2205 7 developed develop VBD cord-015365-iqdi99pd 2205 8 3-fold 3-fold CD cord-015365-iqdi99pd 2205 9 elevated elevated JJ cord-015365-iqdi99pd 2205 10 liver liver NN cord-015365-iqdi99pd 2205 11 enzymes enzyme NNS cord-015365-iqdi99pd 2205 12 ( ( -LRB- cord-015365-iqdi99pd 2205 13 ASAT ASAT NNP cord-015365-iqdi99pd 2205 14 , , , cord-015365-iqdi99pd 2205 15 ALAT ALAT NNP cord-015365-iqdi99pd 2205 16 ) ) -RRB- cord-015365-iqdi99pd 2205 17 within within IN cord-015365-iqdi99pd 2205 18 10.3 10.3 CD cord-015365-iqdi99pd 2205 19 weeks week NNS cord-015365-iqdi99pd 2205 20 after after IN cord-015365-iqdi99pd 2205 21 EOT EOT NNP cord-015365-iqdi99pd 2205 22 ( ( -LRB- cord-015365-iqdi99pd 2205 23 7 7 CD cord-015365-iqdi99pd 2205 24 - - SYM cord-015365-iqdi99pd 2205 25 14 14 CD cord-015365-iqdi99pd 2205 26 ) ) -RRB- cord-015365-iqdi99pd 2206 1 ( ( -LRB- cord-015365-iqdi99pd 2206 2 Biopsies biopsy NNS cord-015365-iqdi99pd 2206 3 were be VBD cord-015365-iqdi99pd 2206 4 not not RB cord-015365-iqdi99pd 2206 5 performed perform VBN cord-015365-iqdi99pd 2206 6 , , , cord-015365-iqdi99pd 2206 7 mostly mostly RB cord-015365-iqdi99pd 2206 8 due due JJ cord-015365-iqdi99pd 2206 9 to to IN cord-015365-iqdi99pd 2206 10 lack lack NN cord-015365-iqdi99pd 2206 11 of of IN cord-015365-iqdi99pd 2206 12 consent consent NN cord-015365-iqdi99pd 2206 13 . . . cord-015365-iqdi99pd 2206 14 ) ) -RRB- cord-015365-iqdi99pd 2206 15 . . . cord-015365-iqdi99pd 2207 1 Patients patient NNS cord-015365-iqdi99pd 2207 2 were be VBD cord-015365-iqdi99pd 2207 3 therefore therefore RB cord-015365-iqdi99pd 2207 4 switched switch VBN cord-015365-iqdi99pd 2207 5 to to IN cord-015365-iqdi99pd 2207 6 triple triple JJ cord-015365-iqdi99pd 2207 7 therapy therapy NN cord-015365-iqdi99pd 2207 8 with with IN cord-015365-iqdi99pd 2207 9 corticosteroids corticosteroid NNS cord-015365-iqdi99pd 2207 10 , , , cord-015365-iqdi99pd 2207 11 CNIs cni NNS cord-015365-iqdi99pd 2207 12 and and CC cord-015365-iqdi99pd 2207 13 MMF mmf NN cord-015365-iqdi99pd 2207 14 . . . cord-015365-iqdi99pd 2208 1 Graft graft NN cord-015365-iqdi99pd 2208 2 dysfunction dysfunction NN cord-015365-iqdi99pd 2208 3 resolved resolve VBD cord-015365-iqdi99pd 2208 4 within within IN cord-015365-iqdi99pd 2208 5 one one CD cord-015365-iqdi99pd 2208 6 to to TO cord-015365-iqdi99pd 2208 7 three three CD cord-015365-iqdi99pd 2208 8 weeks week NNS cord-015365-iqdi99pd 2208 9 after after IN cord-015365-iqdi99pd 2208 10 switch switch NN cord-015365-iqdi99pd 2208 11 . . . cord-015365-iqdi99pd 2209 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2209 2 . . . cord-015365-iqdi99pd 2210 1 Consistent consistent JJ cord-015365-iqdi99pd 2210 2 with with IN cord-015365-iqdi99pd 2210 3 results result NNS cord-015365-iqdi99pd 2210 4 from from IN cord-015365-iqdi99pd 2210 5 the the DT cord-015365-iqdi99pd 2210 6 multi multi JJ cord-015365-iqdi99pd 2210 7 - - JJ cord-015365-iqdi99pd 2210 8 center center JJ cord-015365-iqdi99pd 2210 9 trial trial NN cord-015365-iqdi99pd 2210 10 , , , cord-015365-iqdi99pd 2210 11 patients patient NNS cord-015365-iqdi99pd 2210 12 treated treat VBN cord-015365-iqdi99pd 2210 13 with with IN cord-015365-iqdi99pd 2210 14 belatacept belatacept NN cord-015365-iqdi99pd 2210 15 showed show VBD cord-015365-iqdi99pd 2210 16 better well JJR cord-015365-iqdi99pd 2210 17 kidney kidney NN cord-015365-iqdi99pd 2210 18 function function NN cord-015365-iqdi99pd 2210 19 compared compare VBN cord-015365-iqdi99pd 2210 20 to to IN cord-015365-iqdi99pd 2210 21 those those DT cord-015365-iqdi99pd 2210 22 treated treat VBN cord-015365-iqdi99pd 2210 23 with with IN cord-015365-iqdi99pd 2210 24 CNIs cni NNS cord-015365-iqdi99pd 2210 25 . . . cord-015365-iqdi99pd 2211 1 MMF MMF NNP cord-015365-iqdi99pd 2211 2 monotherapy monotherapy RB cord-015365-iqdi99pd 2211 3 following follow VBG cord-015365-iqdi99pd 2211 4 withdrawal withdrawal NN cord-015365-iqdi99pd 2211 5 of of IN cord-015365-iqdi99pd 2211 6 belatacept belatacept NN cord-015365-iqdi99pd 2211 7 is be VBZ cord-015365-iqdi99pd 2211 8 associated associate VBN cord-015365-iqdi99pd 2211 9 with with IN cord-015365-iqdi99pd 2211 10 a a DT cord-015365-iqdi99pd 2211 11 high high JJ cord-015365-iqdi99pd 2211 12 risk risk NN cord-015365-iqdi99pd 2211 13 of of IN cord-015365-iqdi99pd 2211 14 rejection rejection NN cord-015365-iqdi99pd 2211 15 . . . cord-015365-iqdi99pd 2212 1 Thus thus RB cord-015365-iqdi99pd 2212 2 belatacept belatacept NNP cord-015365-iqdi99pd 2212 3 has have VBZ cord-015365-iqdi99pd 2212 4 no no DT cord-015365-iqdi99pd 2212 5 obvious obvious JJ cord-015365-iqdi99pd 2212 6 immunomodulatory immunomodulatory JJ cord-015365-iqdi99pd 2212 7 effect effect NN cord-015365-iqdi99pd 2212 8 in in IN cord-015365-iqdi99pd 2212 9 liver liver NN cord-015365-iqdi99pd 2212 10 transplant transplant NN cord-015365-iqdi99pd 2212 11 recipients recipient NNS cord-015365-iqdi99pd 2212 12 that that WDT cord-015365-iqdi99pd 2212 13 would would MD cord-015365-iqdi99pd 2212 14 be be VB cord-015365-iqdi99pd 2212 15 sufficient sufficient JJ cord-015365-iqdi99pd 2212 16 to to TO cord-015365-iqdi99pd 2212 17 allow allow VB cord-015365-iqdi99pd 2212 18 a a DT cord-015365-iqdi99pd 2212 19 high high JJ cord-015365-iqdi99pd 2212 20 success success NN cord-015365-iqdi99pd 2212 21 rate rate NN cord-015365-iqdi99pd 2212 22 of of IN cord-015365-iqdi99pd 2212 23 minimization minimization NN cord-015365-iqdi99pd 2212 24 strategies strategy NNS cord-015365-iqdi99pd 2212 25 . . . cord-015365-iqdi99pd 2213 1 Ausgezeichnete Ausgezeichnete NNP cord-015365-iqdi99pd 2213 2 Blutdruckkontrolle Blutdruckkontrolle NNP cord-015365-iqdi99pd 2213 3 nach nach NNP cord-015365-iqdi99pd 2213 4 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 2213 5 durch durch NN cord-015365-iqdi99pd 2213 6 antihypertensive antihypertensive JJ cord-015365-iqdi99pd 2213 7 Mehrfachtherapie Mehrfachtherapie NNP cord-015365-iqdi99pd 2214 1 -Entwicklungen -Entwicklungen . cord-015365-iqdi99pd 2215 1 der der NNP cord-015365-iqdi99pd 2215 2 letzten letzten NNP cord-015365-iqdi99pd 2216 1 20 20 CD cord-015365-iqdi99pd 2216 2 Jahre Jahre NNP cord-015365-iqdi99pd 2216 3 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2216 4 . . . cord-015365-iqdi99pd 2217 1 Patienten Patienten NNP cord-015365-iqdi99pd 2217 2 mit mit VBP cord-015365-iqdi99pd 2217 3 terminalen terminalen NNP cord-015365-iqdi99pd 2217 4 Lebererkrankungen Lebererkrankungen NNP cord-015365-iqdi99pd 2217 5 entwickeln entwickeln NNP cord-015365-iqdi99pd 2218 1 gehäuft gehäuft NNP cord-015365-iqdi99pd 2219 1 Ö Ö NNP cord-015365-iqdi99pd 2219 2 sophagusvarizen sophagusvarizen NNP cord-015365-iqdi99pd 2219 3 auf auf NNP cord-015365-iqdi99pd 2219 4 Basis Basis NNP cord-015365-iqdi99pd 2219 5 einer einer NNP cord-015365-iqdi99pd 2219 6 portalen portalen VBN cord-015365-iqdi99pd 2219 7 Hypertension hypertension NN cord-015365-iqdi99pd 2219 8 . . . cord-015365-iqdi99pd 2220 1 Ziel Ziel NNP cord-015365-iqdi99pd 2220 2 dieser dieser NNP cord-015365-iqdi99pd 2220 3 Studie Studie NNP cord-015365-iqdi99pd 2220 4 ist ist NNP cord-015365-iqdi99pd 2220 5 es es NNP cord-015365-iqdi99pd 2220 6 , , , cord-015365-iqdi99pd 2220 7 die die VB cord-015365-iqdi99pd 2221 1 Inzidenz Inzidenz NNP cord-015365-iqdi99pd 2221 2 von von NNP cord-015365-iqdi99pd 2221 3 Ö Ö NNP cord-015365-iqdi99pd 2221 4 sophagusvarizen sophagusvarizen NN cord-015365-iqdi99pd 2222 1 und und NNP cord-015365-iqdi99pd 2222 2 deren deren NNP cord-015365-iqdi99pd 2222 3 Korrelation Korrelation NNP cord-015365-iqdi99pd 2222 4 mit mit NNP cord-015365-iqdi99pd 2222 5 dem dem NNP cord-015365-iqdi99pd 2222 6 Grad Grad NNP cord-015365-iqdi99pd 2222 7 der der NN cord-015365-iqdi99pd 2222 8 Lebererkrankung Lebererkrankung NNP cord-015365-iqdi99pd 2222 9 bei bei NNP cord-015365-iqdi99pd 2222 10 Patienten Patienten NNP cord-015365-iqdi99pd 2222 11 , , , cord-015365-iqdi99pd 2222 12 die die VBP cord-015365-iqdi99pd 2222 13 auf auf NNP cord-015365-iqdi99pd 2222 14 der der NNP cord-015365-iqdi99pd 2222 15 Leberwarteliste Leberwarteliste NNP cord-015365-iqdi99pd 2222 16 stehen stehen NNP cord-015365-iqdi99pd 2222 17 , , , cord-015365-iqdi99pd 2222 18 zu zu NNP cord-015365-iqdi99pd 2222 19 errechnen errechnen NNP cord-015365-iqdi99pd 2222 20 . . . cord-015365-iqdi99pd 2223 1 Methodik Methodik NNP cord-015365-iqdi99pd 2223 2 . . . cord-015365-iqdi99pd 2224 1 Hierfür Hierfür NNP cord-015365-iqdi99pd 2224 2 wurden wurden NNS cord-015365-iqdi99pd 2224 3 die die VBP cord-015365-iqdi99pd 2224 4 Daten Daten NNP cord-015365-iqdi99pd 2224 5 von von NNP cord-015365-iqdi99pd 2224 6 512 512 CD cord-015365-iqdi99pd 2224 7 Patienten Patienten NNP cord-015365-iqdi99pd 2224 8 , , , cord-015365-iqdi99pd 2224 9 die die VBP cord-015365-iqdi99pd 2224 10 zwischen zwischen NNP cord-015365-iqdi99pd 2224 11 2002 2002 CD cord-015365-iqdi99pd 2224 12 und und IN cord-015365-iqdi99pd 2224 13 2010 2010 CD cord-015365-iqdi99pd 2224 14 an an DT cord-015365-iqdi99pd 2224 15 der der NNP cord-015365-iqdi99pd 2224 16 Universitätsklinik Universitätsklinik NNP cord-015365-iqdi99pd 2224 17 für für IN cord-015365-iqdi99pd 2224 18 Chirurgie Chirurgie NNP cord-015365-iqdi99pd 2224 19 lebertransplantiert lebertransplantiert NNP cord-015365-iqdi99pd 2224 20 wurden wurden NNP cord-015365-iqdi99pd 2224 21 , , , cord-015365-iqdi99pd 2224 22 analysiert analysiert NNP cord-015365-iqdi99pd 2224 23 . . . cord-015365-iqdi99pd 2225 1 Patienten Patienten NNP cord-015365-iqdi99pd 2225 2 , , , cord-015365-iqdi99pd 2225 3 die die VB cord-015365-iqdi99pd 2225 4 die die VB cord-015365-iqdi99pd 2226 1 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2226 2 aufgrund aufgrund IN cord-015365-iqdi99pd 2226 3 eines eines NNP cord-015365-iqdi99pd 2226 4 akuten akuten NNP cord-015365-iqdi99pd 2226 5 Leberausfalls Leberausfalls NNP cord-015365-iqdi99pd 2226 6 benötigten benötigten NNP cord-015365-iqdi99pd 2226 7 und und IN cord-015365-iqdi99pd 2226 8 solche solche NNP cord-015365-iqdi99pd 2226 9 , , , cord-015365-iqdi99pd 2226 10 bei bei NNP cord-015365-iqdi99pd 2226 11 denen denen NNP cord-015365-iqdi99pd 2226 12 die die VBP cord-015365-iqdi99pd 2226 13 Daten Daten NNP cord-015365-iqdi99pd 2226 14 unvollständig unvollständig NNP cord-015365-iqdi99pd 2226 15 waren waren NNP cord-015365-iqdi99pd 2226 16 , , , cord-015365-iqdi99pd 2226 17 wurden wurden NNP cord-015365-iqdi99pd 2226 18 aus aus NNP cord-015365-iqdi99pd 2226 19 der der NNP cord-015365-iqdi99pd 2226 20 Studie Studie NNP cord-015365-iqdi99pd 2226 21 ausgeschlossen ausgeschlossen NNP cord-015365-iqdi99pd 2226 22 . . . cord-015365-iqdi99pd 2227 1 Somit Somit NNP cord-015365-iqdi99pd 2227 2 umfasst umfasst NNP cord-015365-iqdi99pd 2227 3 die die VBP cord-015365-iqdi99pd 2227 4 Studie Studie NNP cord-015365-iqdi99pd 2227 5 396 396 CD cord-015365-iqdi99pd 2227 6 Patienten Patienten NNP cord-015365-iqdi99pd 2227 7 ( ( -LRB- cord-015365-iqdi99pd 2227 8 77 77 CD cord-015365-iqdi99pd 2227 9 % % NN cord-015365-iqdi99pd 2227 10 ) ) -RRB- cord-015365-iqdi99pd 2227 11 . . . cord-015365-iqdi99pd 2228 1 Die die VB cord-015365-iqdi99pd 2228 2 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2228 3 werden werden NNP cord-015365-iqdi99pd 2228 4 median median NN cord-015365-iqdi99pd 2228 5 in in IN cord-015365-iqdi99pd 2228 6 der der NNP cord-015365-iqdi99pd 2228 7 25 25 CD cord-015365-iqdi99pd 2228 8 . . . cord-015365-iqdi99pd 2229 1 und und NNP cord-015365-iqdi99pd 2229 2 der der NNP cord-015365-iqdi99pd 2229 3 75 75 CD cord-015365-iqdi99pd 2229 4 . . . cord-015365-iqdi99pd 2230 1 Perzentile Perzentile NNP cord-015365-iqdi99pd 2230 2 angegeben angegeben NNP cord-015365-iqdi99pd 2230 3 . . . cord-015365-iqdi99pd 2231 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2231 2 . . . cord-015365-iqdi99pd 2232 1 Die die VB cord-015365-iqdi99pd 2233 1 Lebertransplantierten Lebertransplantierten NNP cord-015365-iqdi99pd 2233 2 waren waren XX cord-015365-iqdi99pd 2234 1 i i PRP cord-015365-iqdi99pd 2235 1 m m NNP cord-015365-iqdi99pd 2235 2 Median Median NNP cord-015365-iqdi99pd 2235 3 54 54 CD cord-015365-iqdi99pd 2235 4 ( ( -LRB- cord-015365-iqdi99pd 2235 5 48 48 CD cord-015365-iqdi99pd 2235 6 - - SYM cord-015365-iqdi99pd 2235 7 60 60 CD cord-015365-iqdi99pd 2235 8 ) ) -RRB- cord-015365-iqdi99pd 2235 9 Jahre Jahre NNP cord-015365-iqdi99pd 2235 10 alt alt NN cord-015365-iqdi99pd 2235 11 . . . cord-015365-iqdi99pd 2236 1 I -PRON- PRP cord-015365-iqdi99pd 2237 1 m m NNP cord-015365-iqdi99pd 2237 2 Median Median NNP cord-015365-iqdi99pd 2237 3 lagen lagen NNP cord-015365-iqdi99pd 2237 4 227 227 CD cord-015365-iqdi99pd 2237 5 Tage Tage NNP cord-015365-iqdi99pd 2237 6 ( ( -LRB- cord-015365-iqdi99pd 2237 7 125 125 CD cord-015365-iqdi99pd 2237 8 - - SYM cord-015365-iqdi99pd 2237 9 368 368 CD cord-015365-iqdi99pd 2237 10 ) ) -RRB- cord-015365-iqdi99pd 2238 1 zwischen zwischen NNP cord-015365-iqdi99pd 2238 2 der der NNP cord-015365-iqdi99pd 2238 3 letzten letzten FW cord-015365-iqdi99pd 2238 4 Ö Ö NNP cord-015365-iqdi99pd 2238 5 sophagogastroduodenoskopie sophagogastroduodenoskopie NNP cord-015365-iqdi99pd 2238 6 und und NNP cord-015365-iqdi99pd 2238 7 der der NNP cord-015365-iqdi99pd 2238 8 Lebertransplantation Lebertransplantation NNP cord-015365-iqdi99pd 2238 9 . . . cord-015365-iqdi99pd 2239 1 287 287 CD cord-015365-iqdi99pd 2239 2 Patienten Patienten NNP cord-015365-iqdi99pd 2239 3 ( ( -LRB- cord-015365-iqdi99pd 2239 4 72,5 72,5 CD cord-015365-iqdi99pd 2239 5 % % NN cord-015365-iqdi99pd 2239 6 ) ) -RRB- cord-015365-iqdi99pd 2239 7 zeigten zeigten NNP cord-015365-iqdi99pd 2239 8 Varizen Varizen NNP cord-015365-iqdi99pd 2239 9 : : : cord-015365-iqdi99pd 2239 10 130 130 CD cord-015365-iqdi99pd 2239 11 ( ( -LRB- cord-015365-iqdi99pd 2239 12 32,8 32,8 CD cord-015365-iqdi99pd 2239 13 % % NN cord-015365-iqdi99pd 2239 14 ) ) -RRB- cord-015365-iqdi99pd 2240 1 Varizen Varizen NNP cord-015365-iqdi99pd 2240 2 Grad Grad NNP cord-015365-iqdi99pd 2241 1 I -PRON- PRP cord-015365-iqdi99pd 2241 2 ( ( -LRB- cord-015365-iqdi99pd 2241 3 < < NNP cord-015365-iqdi99pd 2241 4 5 5 CD cord-015365-iqdi99pd 2241 5 mm mm NN cord-015365-iqdi99pd 2241 6 bei bei NNP cord-015365-iqdi99pd 2241 7 Insufflation Insufflation NNP cord-015365-iqdi99pd 2241 8 ) ) -RRB- cord-015365-iqdi99pd 2241 9 und und XX cord-015365-iqdi99pd 2242 1 157 157 CD cord-015365-iqdi99pd 2242 2 ( ( -LRB- cord-015365-iqdi99pd 2242 3 39,6 39,6 CD cord-015365-iqdi99pd 2242 4 % % NN cord-015365-iqdi99pd 2242 5 ) ) -RRB- cord-015365-iqdi99pd 2243 1 Var var NN cord-015365-iqdi99pd 2243 2 - - HYPH cord-015365-iqdi99pd 2243 3 izen izen JJ cord-015365-iqdi99pd 2243 4 Grad Grad NNP cord-015365-iqdi99pd 2243 5 II II NNP cord-015365-iqdi99pd 2244 1 ( ( -LRB- cord-015365-iqdi99pd 2244 2 > > NFP cord-015365-iqdi99pd 2244 3 5 5 CD cord-015365-iqdi99pd 2244 4 mm mm NN cord-015365-iqdi99pd 2244 5 bei bei NNP cord-015365-iqdi99pd 2244 6 Insufflation Insufflation NNP cord-015365-iqdi99pd 2244 7 ) ) -RRB- cord-015365-iqdi99pd 2244 8 . . . cord-015365-iqdi99pd 2245 1 Red Red NNP cord-015365-iqdi99pd 2245 2 Spot Spot NNP cord-015365-iqdi99pd 2245 3 Signs Signs NNPS cord-015365-iqdi99pd 2245 4 fand fand VBP cord-015365-iqdi99pd 2245 5 man man NN cord-015365-iqdi99pd 2245 6 bei bei NNP cord-015365-iqdi99pd 2245 7 40 40 CD cord-015365-iqdi99pd 2246 1 Patienten Patienten NNP cord-015365-iqdi99pd 2246 2 ( ( -LRB- cord-015365-iqdi99pd 2246 3 10,1 10,1 CD cord-015365-iqdi99pd 2246 4 % % NN cord-015365-iqdi99pd 2246 5 ) ) -RRB- cord-015365-iqdi99pd 2246 6 . . . cord-015365-iqdi99pd 2247 1 82,2 82,2 CD cord-015365-iqdi99pd 2247 2 % % NN cord-015365-iqdi99pd 2247 3 der der NNP cord-015365-iqdi99pd 2247 4 Varizen Varizen NNP cord-015365-iqdi99pd 2247 5 lokalisierten lokalisierten NNP cord-015365-iqdi99pd 2247 6 sich sich NNP cord-015365-iqdi99pd 2248 1 i -PRON- PRP cord-015365-iqdi99pd 2248 2 m be VBP cord-015365-iqdi99pd 2248 3 Ö Ö NNP cord-015365-iqdi99pd 2248 4 sophagus sophagus NNP cord-015365-iqdi99pd 2248 5 , , , cord-015365-iqdi99pd 2248 6 4,2 4,2 CD cord-015365-iqdi99pd 2248 7 % % NN cord-015365-iqdi99pd 2249 1 i -PRON- PRP cord-015365-iqdi99pd 2249 2 m be VBP cord-015365-iqdi99pd 2249 3 Magen Magen NNP cord-015365-iqdi99pd 2249 4 und und XX cord-015365-iqdi99pd 2250 1 13,6 13,6 CD cord-015365-iqdi99pd 2250 2 % % NN cord-015365-iqdi99pd 2251 1 i -PRON- PRP cord-015365-iqdi99pd 2251 2 m be VBP cord-015365-iqdi99pd 2251 3 Ö ö NN cord-015365-iqdi99pd 2251 4 sophagus sophagus NNP cord-015365-iqdi99pd 2251 5 und und IN cord-015365-iqdi99pd 2251 6 Magen Magen NNP cord-015365-iqdi99pd 2251 7 . . . cord-015365-iqdi99pd 2252 1 Patienten Patienten NNP cord-015365-iqdi99pd 2252 2 mit mit NNP cord-015365-iqdi99pd 2252 3 ösophagealen ösophagealen NNP cord-015365-iqdi99pd 2253 1 Varizen Varizen NNP cord-015365-iqdi99pd 2253 2 zeigten zeigten NNP cord-015365-iqdi99pd 2254 1 signifikant signifikant NNP cord-015365-iqdi99pd 2255 1 niedrigere niedrigere NNP cord-015365-iqdi99pd 2255 2 Serum Serum NNP cord-015365-iqdi99pd 2255 3 - - HYPH cord-015365-iqdi99pd 2255 4 Natrium Natrium NNP cord-015365-iqdi99pd 2255 5 Werte Werte NNPS cord-015365-iqdi99pd 2256 1 und und NNP cord-015365-iqdi99pd 2256 2 Thrombozytenzahlen Thrombozytenzahlen NNP cord-015365-iqdi99pd 2257 1 und und NNP cord-015365-iqdi99pd 2258 1 signifikant signifikant NNP cord-015365-iqdi99pd 2258 2 höhere höhere NNP cord-015365-iqdi99pd 2258 3 Ammoniak Ammoniak NNP cord-015365-iqdi99pd 2258 4 - - HYPH cord-015365-iqdi99pd 2258 5 Spiegel Spiegel NNP cord-015365-iqdi99pd 2258 6 , , , cord-015365-iqdi99pd 2259 1 Prothrombinzeiten prothrombinzeiten NN cord-015365-iqdi99pd 2259 2 und und XX cord-015365-iqdi99pd 2260 1 MELD meld VB cord-015365-iqdi99pd 2260 2 - - HYPH cord-015365-iqdi99pd 2260 3 Scores score NNS cord-015365-iqdi99pd 2260 4 als als NN cord-015365-iqdi99pd 2260 5 solche solche NN cord-015365-iqdi99pd 2260 6 ohne ohne NNP cord-015365-iqdi99pd 2260 7 Varizen Varizen NNP cord-015365-iqdi99pd 2260 8 . . . cord-015365-iqdi99pd 2261 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2261 2 . . . cord-015365-iqdi99pd 2262 1 Ö Ö NNP cord-015365-iqdi99pd 2262 2 sophagusvarizen sophagusvarizen NNP cord-015365-iqdi99pd 2262 3 treten treten NNP cord-015365-iqdi99pd 2262 4 gehäuft gehäuft NNP cord-015365-iqdi99pd 2262 5 bei bei NNP cord-015365-iqdi99pd 2262 6 Patienten Patienten NNP cord-015365-iqdi99pd 2262 7 mit mit VBP cord-015365-iqdi99pd 2262 8 terminalen terminalen NNP cord-015365-iqdi99pd 2262 9 Lebererkrankungen Lebererkrankungen NNP cord-015365-iqdi99pd 2262 10 auf auf NNP cord-015365-iqdi99pd 2262 11 und und XX cord-015365-iqdi99pd 2263 1 werden werden NNP cord-015365-iqdi99pd 2263 2 von von NNP cord-015365-iqdi99pd 2263 3 einer einer NNP cord-015365-iqdi99pd 2264 1 Verschlechterung Verschlechterung NNP cord-015365-iqdi99pd 2264 2 der der NNP cord-015365-iqdi99pd 2264 3 Labor Labor NNP cord-015365-iqdi99pd 2264 4 - - HYPH cord-015365-iqdi99pd 2264 5 und und IN cord-015365-iqdi99pd 2264 6 MELD MELD NNP cord-015365-iqdi99pd 2264 7 - - HYPH cord-015365-iqdi99pd 2264 8 Werte Werte NNP cord-015365-iqdi99pd 2264 9 begleitet begleitet VBN cord-015365-iqdi99pd 2264 10 . . . cord-015365-iqdi99pd 2265 1 Background background NN cord-015365-iqdi99pd 2265 2 . . . cord-015365-iqdi99pd 2266 1 A a DT cord-015365-iqdi99pd 2266 2 project project NN cord-015365-iqdi99pd 2266 3 called call VBN cord-015365-iqdi99pd 2266 4 Transplant Transplant NNP cord-015365-iqdi99pd 2266 5 Procurement Procurement NNP cord-015365-iqdi99pd 2266 6 Management Management NNP cord-015365-iqdi99pd 2266 7 ( ( -LRB- cord-015365-iqdi99pd 2266 8 TPM TPM NNP cord-015365-iqdi99pd 2266 9 ) ) -RRB- cord-015365-iqdi99pd 2266 10 was be VBD cord-015365-iqdi99pd 2266 11 created create VBN cord-015365-iqdi99pd 2266 12 in in IN cord-015365-iqdi99pd 2266 13 Barcelona Barcelona NNP cord-015365-iqdi99pd 2266 14 , , , cord-015365-iqdi99pd 2266 15 Spain Spain NNP cord-015365-iqdi99pd 2266 16 . . . cord-015365-iqdi99pd 2267 1 The the DT cord-015365-iqdi99pd 2267 2 aim aim NN cord-015365-iqdi99pd 2267 3 of of IN cord-015365-iqdi99pd 2267 4 this this DT cord-015365-iqdi99pd 2267 5 project project NN cord-015365-iqdi99pd 2267 6 is be VBZ cord-015365-iqdi99pd 2267 7 to to TO cord-015365-iqdi99pd 2267 8 provide provide VB cord-015365-iqdi99pd 2267 9 profound profound JJ cord-015365-iqdi99pd 2267 10 knowledge knowledge NN cord-015365-iqdi99pd 2267 11 and and CC cord-015365-iqdi99pd 2267 12 skills skill NNS cord-015365-iqdi99pd 2267 13 for for IN cord-015365-iqdi99pd 2267 14 health health NN cord-015365-iqdi99pd 2267 15 care care NN cord-015365-iqdi99pd 2267 16 professionals professional NNS cord-015365-iqdi99pd 2267 17 , , , cord-015365-iqdi99pd 2267 18 working work VBG cord-015365-iqdi99pd 2267 19 in in IN cord-015365-iqdi99pd 2267 20 the the DT cord-015365-iqdi99pd 2267 21 transplantation transplantation NN cord-015365-iqdi99pd 2267 22 field field NN cord-015365-iqdi99pd 2267 23 with with IN cord-015365-iqdi99pd 2267 24 the the DT cord-015365-iqdi99pd 2267 25 final final JJ cord-015365-iqdi99pd 2267 26 purpose purpose NN cord-015365-iqdi99pd 2267 27 of of IN cord-015365-iqdi99pd 2267 28 promoting promote VBG cord-015365-iqdi99pd 2267 29 and and CC cord-015365-iqdi99pd 2267 30 increasing increase VBG cord-015365-iqdi99pd 2267 31 donation donation NN cord-015365-iqdi99pd 2267 32 rates rate NNS cord-015365-iqdi99pd 2267 33 . . . cord-015365-iqdi99pd 2268 1 We -PRON- PRP cord-015365-iqdi99pd 2268 2 evaluated evaluate VBD cord-015365-iqdi99pd 2268 3 the the DT cord-015365-iqdi99pd 2268 4 effects effect NNS cord-015365-iqdi99pd 2268 5 of of IN cord-015365-iqdi99pd 2268 6 this this DT cord-015365-iqdi99pd 2268 7 program program NN cord-015365-iqdi99pd 2268 8 on on IN cord-015365-iqdi99pd 2268 9 donor donor NN cord-015365-iqdi99pd 2268 10 outcome outcome NN cord-015365-iqdi99pd 2268 11 and and CC cord-015365-iqdi99pd 2268 12 the the DT cord-015365-iqdi99pd 2268 13 organ organ NN cord-015365-iqdi99pd 2268 14 procurement procurement NN cord-015365-iqdi99pd 2268 15 in in IN cord-015365-iqdi99pd 2268 16 a a DT cord-015365-iqdi99pd 2268 17 single single JJ cord-015365-iqdi99pd 2268 18 center center NN cord-015365-iqdi99pd 2268 19 analysis analysis NN cord-015365-iqdi99pd 2268 20 . . . cord-015365-iqdi99pd 2269 1 Methods method NNS cord-015365-iqdi99pd 2269 2 . . . cord-015365-iqdi99pd 2270 1 Number number NN cord-015365-iqdi99pd 2270 2 of of IN cord-015365-iqdi99pd 2270 3 donor donor NN cord-015365-iqdi99pd 2270 4 procurements procurement NNS cord-015365-iqdi99pd 2270 5 over over IN cord-015365-iqdi99pd 2270 6 a a DT cord-015365-iqdi99pd 2270 7 1-year 1-year CD cord-015365-iqdi99pd 2270 8 period period NN cord-015365-iqdi99pd 2270 9 , , , cord-015365-iqdi99pd 2270 10 from from IN cord-015365-iqdi99pd 2270 11 June June NNP cord-015365-iqdi99pd 2270 12 1st 1st NN cord-015365-iqdi99pd 2270 13 , , , cord-015365-iqdi99pd 2270 14 2010 2010 CD cord-015365-iqdi99pd 2270 15 to to IN cord-015365-iqdi99pd 2270 16 May May NNP cord-015365-iqdi99pd 2270 17 31st 31st NN cord-015365-iqdi99pd 2270 18 , , , cord-015365-iqdi99pd 2270 19 2011 2011 CD cord-015365-iqdi99pd 2270 20 , , , cord-015365-iqdi99pd 2270 21 evaluated evaluate VBN cord-015365-iqdi99pd 2270 22 at at IN cord-015365-iqdi99pd 2270 23 the the DT cord-015365-iqdi99pd 2270 24 transplant transplant NN cord-015365-iqdi99pd 2270 25 center center NN cord-015365-iqdi99pd 2270 26 of of IN cord-015365-iqdi99pd 2270 27 the the DT cord-015365-iqdi99pd 2270 28 Medical Medical NNP cord-015365-iqdi99pd 2270 29 University University NNP cord-015365-iqdi99pd 2270 30 Vienna Vienna NNP cord-015365-iqdi99pd 2270 31 , , , cord-015365-iqdi99pd 2270 32 the the DT cord-015365-iqdi99pd 2270 33 sixmonth sixmonth JJ cord-015365-iqdi99pd 2270 34 period period NN cord-015365-iqdi99pd 2270 35 before before RB cord-015365-iqdi99pd 2270 36 and and CC cord-015365-iqdi99pd 2270 37 after after IN cord-015365-iqdi99pd 2270 38 participation participation NN cord-015365-iqdi99pd 2270 39 in in IN cord-015365-iqdi99pd 2270 40 the the DT cord-015365-iqdi99pd 2270 41 TPM TPM NNP cord-015365-iqdi99pd 2270 42 - - HYPH cord-015365-iqdi99pd 2270 43 course course NN cord-015365-iqdi99pd 2270 44 ( ( -LRB- cord-015365-iqdi99pd 2270 45 Nov Nov NNP cord-015365-iqdi99pd 2270 46 22nd 22nd NN cord-015365-iqdi99pd 2270 47 to to IN cord-015365-iqdi99pd 2270 48 Nov Nov NNP cord-015365-iqdi99pd 2270 49 26th 26th NN cord-015365-iqdi99pd 2270 50 , , , cord-015365-iqdi99pd 2270 51 2010 2010 CD cord-015365-iqdi99pd 2270 52 ) ) -RRB- cord-015365-iqdi99pd 2270 53 . . . cord-015365-iqdi99pd 2271 1 Results result NNS cord-015365-iqdi99pd 2271 2 . . . cord-015365-iqdi99pd 2272 1 In in IN cord-015365-iqdi99pd 2272 2 the the DT cord-015365-iqdi99pd 2272 3 1st 1st JJ cord-015365-iqdi99pd 2272 4 evaluation evaluation NN cord-015365-iqdi99pd 2272 5 period period NN cord-015365-iqdi99pd 2272 6 from from IN cord-015365-iqdi99pd 2272 7 June June NNP cord-015365-iqdi99pd 2272 8 1st 1st NN cord-015365-iqdi99pd 2272 9 to to IN cord-015365-iqdi99pd 2272 10 Nov Nov NNP cord-015365-iqdi99pd 2272 11 30th 30th NN cord-015365-iqdi99pd 2272 12 , , , cord-015365-iqdi99pd 2272 13 2010 2010 CD cord-015365-iqdi99pd 2272 14 74 74 CD cord-015365-iqdi99pd 2272 15 potential potential JJ cord-015365-iqdi99pd 2272 16 donors donor NNS cord-015365-iqdi99pd 2272 17 were be VBD cord-015365-iqdi99pd 2272 18 reported report VBN cord-015365-iqdi99pd 2272 19 in in IN cord-015365-iqdi99pd 2272 20 our -PRON- PRP$ cord-015365-iqdi99pd 2272 21 center center NN cord-015365-iqdi99pd 2272 22 out out IN cord-015365-iqdi99pd 2272 23 of of IN cord-015365-iqdi99pd 2272 24 which which WDT cord-015365-iqdi99pd 2272 25 31 31 CD cord-015365-iqdi99pd 2272 26 became become VBD cord-015365-iqdi99pd 2272 27 actual actual JJ cord-015365-iqdi99pd 2272 28 donors donor NNS cord-015365-iqdi99pd 2272 29 . . . cord-015365-iqdi99pd 2273 1 Within within IN cord-015365-iqdi99pd 2273 2 the the DT cord-015365-iqdi99pd 2273 3 43 43 CD cord-015365-iqdi99pd 2273 4 missed miss VBN cord-015365-iqdi99pd 2273 5 donors donor NNS cord-015365-iqdi99pd 2273 6 23 23 CD cord-015365-iqdi99pd 2273 7 did do VBD cord-015365-iqdi99pd 2273 8 not not RB cord-015365-iqdi99pd 2273 9 fulfill fulfill VB cord-015365-iqdi99pd 2273 10 brain brain NN cord-015365-iqdi99pd 2273 11 dead dead JJ cord-015365-iqdi99pd 2273 12 criteria criterion NNS cord-015365-iqdi99pd 2273 13 . . . cord-015365-iqdi99pd 2274 1 Moreover moreover RB cord-015365-iqdi99pd 2274 2 twelve twelve CD cord-015365-iqdi99pd 2274 3 donors donor NNS cord-015365-iqdi99pd 2274 4 could could MD cord-015365-iqdi99pd 2274 5 not not RB cord-015365-iqdi99pd 2274 6 be be VB cord-015365-iqdi99pd 2274 7 realized realize VBN cord-015365-iqdi99pd 2274 8 because because IN cord-015365-iqdi99pd 2274 9 of of IN cord-015365-iqdi99pd 2274 10 their -PRON- PRP$ cord-015365-iqdi99pd 2274 11 co co NNS cord-015365-iqdi99pd 2274 12 - - NNS cord-015365-iqdi99pd 2274 13 morbidities morbidity NNS cord-015365-iqdi99pd 2274 14 and and CC cord-015365-iqdi99pd 2274 15 eight eight CD cord-015365-iqdi99pd 2274 16 due due JJ cord-015365-iqdi99pd 2274 17 to to IN cord-015365-iqdi99pd 2274 18 opposition opposition NN cord-015365-iqdi99pd 2274 19 against against IN cord-015365-iqdi99pd 2274 20 organ organ NN cord-015365-iqdi99pd 2274 21 donation donation NN cord-015365-iqdi99pd 2274 22 . . . cord-015365-iqdi99pd 2275 1 In in IN cord-015365-iqdi99pd 2275 2 the the DT cord-015365-iqdi99pd 2275 3 comparable comparable JJ cord-015365-iqdi99pd 2275 4 2nd 2nd JJ cord-015365-iqdi99pd 2275 5 period period NN cord-015365-iqdi99pd 2275 6 from from IN cord-015365-iqdi99pd 2275 7 Dec Dec NNP cord-015365-iqdi99pd 2275 8 1st 1st NN cord-015365-iqdi99pd 2275 9 to to IN cord-015365-iqdi99pd 2275 10 May May NNP cord-015365-iqdi99pd 2275 11 31st 31st NN cord-015365-iqdi99pd 2275 12 , , , cord-015365-iqdi99pd 2275 13 2011 2011 CD cord-015365-iqdi99pd 2275 14 we -PRON- PRP cord-015365-iqdi99pd 2275 15 registered register VBD cord-015365-iqdi99pd 2275 16 an an DT cord-015365-iqdi99pd 2275 17 increase increase NN cord-015365-iqdi99pd 2275 18 of of IN cord-015365-iqdi99pd 2275 19 42 42 CD cord-015365-iqdi99pd 2275 20 actual actual JJ cord-015365-iqdi99pd 2275 21 donors donor NNS cord-015365-iqdi99pd 2275 22 out out IN cord-015365-iqdi99pd 2275 23 of of IN cord-015365-iqdi99pd 2275 24 69 69 CD cord-015365-iqdi99pd 2275 25 potentials potential NNS cord-015365-iqdi99pd 2275 26 . . . cord-015365-iqdi99pd 2276 1 Thirteen thirteen CD cord-015365-iqdi99pd 2276 2 donors donor NNS cord-015365-iqdi99pd 2276 3 were be VBD cord-015365-iqdi99pd 2276 4 missed miss VBN cord-015365-iqdi99pd 2276 5 because because IN cord-015365-iqdi99pd 2276 6 of of IN cord-015365-iqdi99pd 2276 7 unaccomplished unaccomplished JJ cord-015365-iqdi99pd 2276 8 brain brain NN cord-015365-iqdi99pd 2276 9 dead dead JJ cord-015365-iqdi99pd 2276 10 criteria criterion NNS cord-015365-iqdi99pd 2276 11 . . . cord-015365-iqdi99pd 2277 1 Moreover moreover RB cord-015365-iqdi99pd 2277 2 eight eight CD cord-015365-iqdi99pd 2277 3 donors donor NNS cord-015365-iqdi99pd 2277 4 were be VBD cord-015365-iqdi99pd 2277 5 lost lose VBN cord-015365-iqdi99pd 2277 6 due due IN cord-015365-iqdi99pd 2277 7 to to IN cord-015365-iqdi99pd 2277 8 their -PRON- PRP$ cord-015365-iqdi99pd 2277 9 co co NNS cord-015365-iqdi99pd 2277 10 - - NNS cord-015365-iqdi99pd 2277 11 morbidities morbidity NNS cord-015365-iqdi99pd 2277 12 and and CC cord-015365-iqdi99pd 2277 13 six six CD cord-015365-iqdi99pd 2277 14 because because IN cord-015365-iqdi99pd 2277 15 of of IN cord-015365-iqdi99pd 2277 16 opposition opposition NN cord-015365-iqdi99pd 2277 17 against against IN cord-015365-iqdi99pd 2277 18 organ organ NN cord-015365-iqdi99pd 2277 19 donation donation NN cord-015365-iqdi99pd 2277 20 . . . cord-015365-iqdi99pd 2278 1 However however RB cord-015365-iqdi99pd 2278 2 during during IN cord-015365-iqdi99pd 2278 3 this this DT cord-015365-iqdi99pd 2278 4 evaluation evaluation NN cord-015365-iqdi99pd 2278 5 period period NN cord-015365-iqdi99pd 2278 6 the the DT cord-015365-iqdi99pd 2278 7 donor donor NN cord-015365-iqdi99pd 2278 8 rates rate NNS cord-015365-iqdi99pd 2278 9 increased increase VBD cord-015365-iqdi99pd 2278 10 for for IN cord-015365-iqdi99pd 2278 11 about about RB cord-015365-iqdi99pd 2278 12 35 35 CD cord-015365-iqdi99pd 2278 13 % % NN cord-015365-iqdi99pd 2278 14 . . . cord-015365-iqdi99pd 2279 1 The the DT cord-015365-iqdi99pd 2279 2 procurement procurement NN cord-015365-iqdi99pd 2279 3 of of IN cord-015365-iqdi99pd 2279 4 transplantable transplantable JJ cord-015365-iqdi99pd 2279 5 kidneys kidney NNS cord-015365-iqdi99pd 2279 6 increased increase VBD cord-015365-iqdi99pd 2279 7 from from IN cord-015365-iqdi99pd 2279 8 60 60 CD cord-015365-iqdi99pd 2279 9 to to IN cord-015365-iqdi99pd 2279 10 66 66 CD cord-015365-iqdi99pd 2279 11 , , , cord-015365-iqdi99pd 2279 12 transplantable transplantable JJ cord-015365-iqdi99pd 2279 13 lungs lung NNS cord-015365-iqdi99pd 2279 14 increased increase VBD cord-015365-iqdi99pd 2279 15 from from IN cord-015365-iqdi99pd 2279 16 12 12 CD cord-015365-iqdi99pd 2279 17 to to TO cord-015365-iqdi99pd 2279 18 13 13 CD cord-015365-iqdi99pd 2279 19 and and CC cord-015365-iqdi99pd 2279 20 in in IN cord-015365-iqdi99pd 2279 21 liver liver NN cord-015365-iqdi99pd 2279 22 procurement procurement NN cord-015365-iqdi99pd 2279 23 , , , cord-015365-iqdi99pd 2279 24 we -PRON- PRP cord-015365-iqdi99pd 2279 25 could could MD cord-015365-iqdi99pd 2279 26 even even RB cord-015365-iqdi99pd 2279 27 register register VB cord-015365-iqdi99pd 2279 28 an an DT cord-015365-iqdi99pd 2279 29 increase increase NN cord-015365-iqdi99pd 2279 30 from from IN cord-015365-iqdi99pd 2279 31 13 13 CD cord-015365-iqdi99pd 2279 32 to to TO cord-015365-iqdi99pd 2279 33 22 22 CD cord-015365-iqdi99pd 2279 34 transplantable transplantable JJ cord-015365-iqdi99pd 2279 35 organs organ NNS cord-015365-iqdi99pd 2279 36 . . . cord-015365-iqdi99pd 2280 1 Only only RB cord-015365-iqdi99pd 2280 2 in in IN cord-015365-iqdi99pd 2280 3 heart heart NN cord-015365-iqdi99pd 2280 4 procurement procurement NN cord-015365-iqdi99pd 2280 5 we -PRON- PRP cord-015365-iqdi99pd 2280 6 registered register VBD cord-015365-iqdi99pd 2280 7 a a DT cord-015365-iqdi99pd 2280 8 decrease decrease NN cord-015365-iqdi99pd 2280 9 from from IN cord-015365-iqdi99pd 2280 10 16 16 CD cord-015365-iqdi99pd 2280 11 to to TO cord-015365-iqdi99pd 2280 12 13 13 CD cord-015365-iqdi99pd 2280 13 transplantable transplantable JJ cord-015365-iqdi99pd 2280 14 organs organ NNS cord-015365-iqdi99pd 2280 15 . . . cord-015365-iqdi99pd 2281 1 These these DT cord-015365-iqdi99pd 2281 2 results result NNS cord-015365-iqdi99pd 2281 3 show show VBP cord-015365-iqdi99pd 2281 4 a a DT cord-015365-iqdi99pd 2281 5 remarkable remarkable JJ cord-015365-iqdi99pd 2281 6 effect effect NN cord-015365-iqdi99pd 2281 7 of of IN cord-015365-iqdi99pd 2281 8 this this DT cord-015365-iqdi99pd 2281 9 training training NN cord-015365-iqdi99pd 2281 10 program program NN cord-015365-iqdi99pd 2281 11 as as RB cord-015365-iqdi99pd 2281 12 well well RB cord-015365-iqdi99pd 2281 13 as as IN cord-015365-iqdi99pd 2281 14 the the DT cord-015365-iqdi99pd 2281 15 fluctuation fluctuation NN cord-015365-iqdi99pd 2281 16 of of IN cord-015365-iqdi99pd 2281 17 potential potential JJ cord-015365-iqdi99pd 2281 18 donors donor NNS cord-015365-iqdi99pd 2281 19 and and CC cord-015365-iqdi99pd 2281 20 the the DT cord-015365-iqdi99pd 2281 21 diverse diverse JJ cord-015365-iqdi99pd 2281 22 potential potential NN cord-015365-iqdi99pd 2281 23 of of IN cord-015365-iqdi99pd 2281 24 organ organ NN cord-015365-iqdi99pd 2281 25 recovery recovery NN cord-015365-iqdi99pd 2281 26 during during IN cord-015365-iqdi99pd 2281 27 this this DT cord-015365-iqdi99pd 2281 28 year year NN cord-015365-iqdi99pd 2281 29 . . . cord-015365-iqdi99pd 2282 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2282 2 . . . cord-015365-iqdi99pd 2283 1 After after IN cord-015365-iqdi99pd 2283 2 all all DT cord-015365-iqdi99pd 2283 3 training training NN cord-015365-iqdi99pd 2283 4 programs program NNS cord-015365-iqdi99pd 2283 5 in in IN cord-015365-iqdi99pd 2283 6 organ organ NN cord-015365-iqdi99pd 2283 7 donation donation NN cord-015365-iqdi99pd 2283 8 are be VBP cord-015365-iqdi99pd 2283 9 an an DT cord-015365-iqdi99pd 2283 10 interesting interesting JJ cord-015365-iqdi99pd 2283 11 field field NN cord-015365-iqdi99pd 2283 12 and and CC cord-015365-iqdi99pd 2283 13 seem seem VBP cord-015365-iqdi99pd 2283 14 to to TO cord-015365-iqdi99pd 2283 15 increase increase VB cord-015365-iqdi99pd 2283 16 organ organ NN cord-015365-iqdi99pd 2283 17 donation donation NN cord-015365-iqdi99pd 2283 18 rates rate NNS cord-015365-iqdi99pd 2283 19 . . . cord-015365-iqdi99pd 2284 1 Efforts effort NNS cord-015365-iqdi99pd 2284 2 have have VBP cord-015365-iqdi99pd 2284 3 to to TO cord-015365-iqdi99pd 2284 4 be be VB cord-015365-iqdi99pd 2284 5 made make VBN cord-015365-iqdi99pd 2284 6 to to TO cord-015365-iqdi99pd 2284 7 provide provide VB cord-015365-iqdi99pd 2284 8 and and CC cord-015365-iqdi99pd 2284 9 spread spread VB cord-015365-iqdi99pd 2284 10 profound profound JJ cord-015365-iqdi99pd 2284 11 knowledge knowledge NN cord-015365-iqdi99pd 2284 12 and and CC cord-015365-iqdi99pd 2284 13 skills skill NNS cord-015365-iqdi99pd 2284 14 for for IN cord-015365-iqdi99pd 2284 15 health health NN cord-015365-iqdi99pd 2284 16 care care NN cord-015365-iqdi99pd 2284 17 professionals professional NNS cord-015365-iqdi99pd 2284 18 , , , cord-015365-iqdi99pd 2284 19 working work VBG cord-015365-iqdi99pd 2284 20 in in IN cord-015365-iqdi99pd 2284 21 the the DT cord-015365-iqdi99pd 2284 22 transplantation transplantation NN cord-015365-iqdi99pd 2284 23 field field NN cord-015365-iqdi99pd 2284 24 . . . cord-015365-iqdi99pd 2285 1 pneumonia pneumonia NN cord-015365-iqdi99pd 2285 2 and and CC cord-015365-iqdi99pd 2285 3 had have VBD cord-015365-iqdi99pd 2285 4 to to TO cord-015365-iqdi99pd 2285 5 be be VB cord-015365-iqdi99pd 2285 6 admitted admit VBN cord-015365-iqdi99pd 2285 7 . . . cord-015365-iqdi99pd 2286 1 The the DT cord-015365-iqdi99pd 2286 2 patient patient NN cord-015365-iqdi99pd 2286 3 with with IN cord-015365-iqdi99pd 2286 4 BOS BOS NNP cord-015365-iqdi99pd 2286 5 II II NNP cord-015365-iqdi99pd 2286 6 died die VBD cord-015365-iqdi99pd 2286 7 due due JJ cord-015365-iqdi99pd 2286 8 to to IN cord-015365-iqdi99pd 2286 9 acute acute JJ cord-015365-iqdi99pd 2286 10 respiratory respiratory JJ cord-015365-iqdi99pd 2286 11 distress distress NN cord-015365-iqdi99pd 2286 12 syndrome syndrome NN cord-015365-iqdi99pd 2286 13 ( ( -LRB- cord-015365-iqdi99pd 2286 14 ARDS ARDS NNP cord-015365-iqdi99pd 2286 15 ) ) -RRB- cord-015365-iqdi99pd 2286 16 . . . cord-015365-iqdi99pd 2287 1 Both both DT cord-015365-iqdi99pd 2287 2 patients patient NNS cord-015365-iqdi99pd 2287 3 received receive VBD cord-015365-iqdi99pd 2287 4 no no DT cord-015365-iqdi99pd 2287 5 vaccination vaccination NN cord-015365-iqdi99pd 2287 6 . . . cord-015365-iqdi99pd 2288 1 The the DT cord-015365-iqdi99pd 2288 2 other other JJ cord-015365-iqdi99pd 2288 3 two two CD cord-015365-iqdi99pd 2288 4 LTRs ltr NNS cord-015365-iqdi99pd 2288 5 , , , cord-015365-iqdi99pd 2288 6 one one CD cord-015365-iqdi99pd 2288 7 with with IN cord-015365-iqdi99pd 2288 8 BOS BOS NNP cord-015365-iqdi99pd 2289 1 I -PRON- PRP cord-015365-iqdi99pd 2289 2 the the DT cord-015365-iqdi99pd 2289 3 other other JJ cord-015365-iqdi99pd 2289 4 with with IN cord-015365-iqdi99pd 2289 5 BOS BOS NNP cord-015365-iqdi99pd 2289 6 II II NNP cord-015365-iqdi99pd 2289 7 and and CC cord-015365-iqdi99pd 2289 8 active active JJ cord-015365-iqdi99pd 2289 9 vaccination vaccination NN cord-015365-iqdi99pd 2289 10 protection protection NN cord-015365-iqdi99pd 2289 11 were be VBD cord-015365-iqdi99pd 2289 12 treated treat VBN cord-015365-iqdi99pd 2289 13 with with IN cord-015365-iqdi99pd 2289 14 Oseltamivir Oseltamivir NNP cord-015365-iqdi99pd 2289 15 at at IN cord-015365-iqdi99pd 2289 16 the the DT cord-015365-iqdi99pd 2289 17 time time NN cord-015365-iqdi99pd 2289 18 of of IN cord-015365-iqdi99pd 2289 19 the the DT cord-015365-iqdi99pd 2289 20 first first JJ cord-015365-iqdi99pd 2289 21 clinical clinical JJ cord-015365-iqdi99pd 2289 22 assessment assessment NN cord-015365-iqdi99pd 2289 23 , , , cord-015365-iqdi99pd 2289 24 without without IN cord-015365-iqdi99pd 2289 25 any any DT cord-015365-iqdi99pd 2289 26 further further JJ cord-015365-iqdi99pd 2289 27 respiratory respiratory JJ cord-015365-iqdi99pd 2289 28 complications complication NNS cord-015365-iqdi99pd 2289 29 . . . cord-015365-iqdi99pd 2290 1 Therapy therapy NN cord-015365-iqdi99pd 2290 2 with with IN cord-015365-iqdi99pd 2290 3 Oseltamivir Oseltamivir NNP cord-015365-iqdi99pd 2290 4 was be VBD cord-015365-iqdi99pd 2290 5 only only RB cord-015365-iqdi99pd 2290 6 started start VBN cord-015365-iqdi99pd 2290 7 with with IN cord-015365-iqdi99pd 2290 8 clinical clinical JJ cord-015365-iqdi99pd 2290 9 assessment assessment NN cord-015365-iqdi99pd 2290 10 within within IN cord-015365-iqdi99pd 2290 11 the the DT cord-015365-iqdi99pd 2290 12 first first JJ cord-015365-iqdi99pd 2290 13 48 48 CD cord-015365-iqdi99pd 2290 14 hours hour NNS cord-015365-iqdi99pd 2290 15 . . . cord-015365-iqdi99pd 2291 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2291 2 . . . cord-015365-iqdi99pd 2292 1 Our -PRON- PRP$ cord-015365-iqdi99pd 2292 2 review review NN cord-015365-iqdi99pd 2292 3 shows show VBZ cord-015365-iqdi99pd 2292 4 a a DT cord-015365-iqdi99pd 2292 5 causal causal JJ cord-015365-iqdi99pd 2292 6 link link NN cord-015365-iqdi99pd 2292 7 between between IN cord-015365-iqdi99pd 2292 8 preexisting preexist VBG cord-015365-iqdi99pd 2292 9 BOS BOS NNP cord-015365-iqdi99pd 2292 10 , , , cord-015365-iqdi99pd 2292 11 vaccination vaccination NN cord-015365-iqdi99pd 2292 12 state state NN cord-015365-iqdi99pd 2292 13 and and CC cord-015365-iqdi99pd 2292 14 the the DT cord-015365-iqdi99pd 2292 15 severeness severeness NN cord-015365-iqdi99pd 2292 16 of of IN cord-015365-iqdi99pd 2292 17 respiratory respiratory JJ cord-015365-iqdi99pd 2292 18 symptoms symptom NNS cord-015365-iqdi99pd 2292 19 after after IN cord-015365-iqdi99pd 2292 20 infection infection NN cord-015365-iqdi99pd 2292 21 with with IN cord-015365-iqdi99pd 2292 22 community community NN cord-015365-iqdi99pd 2292 23 acquired acquire VBD cord-015365-iqdi99pd 2292 24 respiratory respiratory JJ cord-015365-iqdi99pd 2292 25 viruses virus NNS cord-015365-iqdi99pd 2292 26 and and CC cord-015365-iqdi99pd 2292 27 the the DT cord-015365-iqdi99pd 2292 28 clinical clinical JJ cord-015365-iqdi99pd 2292 29 effectiveness effectiveness NN cord-015365-iqdi99pd 2292 30 of of IN cord-015365-iqdi99pd 2292 31 seasonal seasonal JJ cord-015365-iqdi99pd 2292 32 influenza influenza NN cord-015365-iqdi99pd 2292 33 vaccination vaccination NN cord-015365-iqdi99pd 2292 34 especially especially RB cord-015365-iqdi99pd 2292 35 in in IN cord-015365-iqdi99pd 2292 36 BOS BOS NNP cord-015365-iqdi99pd 2292 37 patients patient NNS cord-015365-iqdi99pd 2292 38 . . . cord-015365-iqdi99pd 2293 1 A. A. NNP cord-015365-iqdi99pd 2293 2 Scheed Scheed NNP cord-015365-iqdi99pd 2293 3 1 1 CD cord-015365-iqdi99pd 2293 4 , , , cord-015365-iqdi99pd 2293 5 A. A. NNP cord-015365-iqdi99pd 2293 6 Aliabadi Aliabadi NNP cord-015365-iqdi99pd 2293 7 2 2 CD cord-015365-iqdi99pd 2293 8 , , , cord-015365-iqdi99pd 2293 9 P. P. NNP cord-015365-iqdi99pd 2293 10 Jaksch Jaksch NNP cord-015365-iqdi99pd 2293 11 1 1 CD cord-015365-iqdi99pd 2293 12 , , , cord-015365-iqdi99pd 2293 13 S. S. NNP cord-015365-iqdi99pd 2293 14 Taghavi Taghavi NNP cord-015365-iqdi99pd 2293 15 1 1 CD cord-015365-iqdi99pd 2293 16 , , , cord-015365-iqdi99pd 2293 17 W. W. NNP cord-015365-iqdi99pd 2293 18 Klepetko Klepetko NNP cord-015365-iqdi99pd 2293 19 1 1 CD cord-015365-iqdi99pd 2293 20 , , , cord-015365-iqdi99pd 2293 21 A. A. NNP cord-015365-iqdi99pd 2293 22 Zuckermann Zuckermann NNP cord-015365-iqdi99pd 2293 23 2 2 CD cord-015365-iqdi99pd 2293 24 Bei Bei NNP cord-015365-iqdi99pd 2293 25 836 836 CD cord-015365-iqdi99pd 2293 26 Patienten Patienten NNP cord-015365-iqdi99pd 2293 27 mit mit NN cord-015365-iqdi99pd 2293 28 funktionierendem funktionierendem JJ cord-015365-iqdi99pd 2293 29 Transplantat Transplantat NNP cord-015365-iqdi99pd 2293 30 ein ein NNP cord-015365-iqdi99pd 2293 31 Jahr Jahr NNP cord-015365-iqdi99pd 2293 32 nach nach NN cord-015365-iqdi99pd 2293 33 der der NNP cord-015365-iqdi99pd 2293 34 Transplantation Transplantation NNP cord-015365-iqdi99pd 2293 35 , , , cord-015365-iqdi99pd 2293 36 die die VBP cord-015365-iqdi99pd 2293 37 in in IN cord-015365-iqdi99pd 2293 38 unterschiedlichen unterschiedlichen NN cord-015365-iqdi99pd 2293 39 Perioden Perioden NNP cord-015365-iqdi99pd 2294 1 1990/1991 1990/1991 CD cord-015365-iqdi99pd 2294 2 ( ( -LRB- cord-015365-iqdi99pd 2294 3 n n CC cord-015365-iqdi99pd 2294 4 ¼ ¼ NNP cord-015365-iqdi99pd 2294 5 129 129 CD cord-015365-iqdi99pd 2294 6 ) ) -RRB- cord-015365-iqdi99pd 2294 7 sowie sowie CD cord-015365-iqdi99pd 2294 8 die die VBP cord-015365-iqdi99pd 2295 1 i -PRON- PRP cord-015365-iqdi99pd 2295 2 m be VBP cord-015365-iqdi99pd 2295 3 Rahmen Rahmen NNP cord-015365-iqdi99pd 2295 4 von von NNP cord-015365-iqdi99pd 2295 5 Patientenselbstmessungen Patientenselbstmessungen NNP cord-015365-iqdi99pd 2295 6 erhobenen erhobenen NNP cord-015365-iqdi99pd 2295 7 Blutdruckwerte Blutdruckwerte NNP cord-015365-iqdi99pd 2295 8 analysiert analysiert NN cord-015365-iqdi99pd 2295 9 Bei Bei NNP cord-015365-iqdi99pd 2295 10 Patienten Patienten NNP cord-015365-iqdi99pd 2295 11 , , , cord-015365-iqdi99pd 2295 12 die die VBP cord-015365-iqdi99pd 2295 13 auf auf NNP cord-015365-iqdi99pd 2295 14 der der NNP cord-015365-iqdi99pd 2295 15 Leberwarteliste Leberwarteliste NNP cord-015365-iqdi99pd 2295 16 stehen stehen NNP cord-015365-iqdi99pd 2295 17 , , , cord-015365-iqdi99pd 2295 18 korrelieren korrelieren NNP cord-015365-iqdi99pd 2295 19 ösophagogastrale ösophagogastrale NNP cord-015365-iqdi99pd 2295 20 Varizen Varizen NNP cord-015365-iqdi99pd 2295 21 mit mit NNP cord-015365-iqdi99pd 2295 22 dem dem NNP cord-015365-iqdi99pd 2295 23 Grad Grad NNP cord-015365-iqdi99pd 2295 24 der der NNP cord-015365-iqdi99pd 2295 25 Lebererkrankung Lebererkrankung NNP cord-015365-iqdi99pd 2295 26 R. R. NNP cord-015365-iqdi99pd 2295 27 Schwarzer Schwarzer NNP cord-015365-iqdi99pd 2295 28 1 1 CD cord-015365-iqdi99pd 2295 29 , , , cord-015365-iqdi99pd 2295 30 M. M. NNP cord-015365-iqdi99pd 2295 31 Thum Thum NNP cord-015365-iqdi99pd 2295 32 1 1 CD cord-015365-iqdi99pd 2295 33 , , , cord-015365-iqdi99pd 2295 34 R. R. NNP cord-015365-iqdi99pd 2295 35 Karatosic Karatosic NNP cord-015365-iqdi99pd 2295 36 2 2 CD cord-015365-iqdi99pd 2295 37 , , , cord-015365-iqdi99pd 2296 1 U. U. NNP cord-015365-iqdi99pd 2296 2 Burger Burger NNP cord-015365-iqdi99pd 2296 3 - - HYPH cord-015365-iqdi99pd 2296 4 Klepp Klepp NNP cord-015365-iqdi99pd 2296 5 Mark Mark NNP cord-015365-iqdi99pd 2296 6 1 1 CD cord-015365-iqdi99pd 2296 7 of of IN cord-015365-iqdi99pd 2296 8 recipient- recipient- NN cord-015365-iqdi99pd 2296 9 , , , cord-015365-iqdi99pd 2296 10 donor donor NN cord-015365-iqdi99pd 2296 11 - - HYPH cord-015365-iqdi99pd 2296 12 and and CC cord-015365-iqdi99pd 2296 13 transplantcharacteristics transplantcharacteristic NNS cord-015365-iqdi99pd 2296 14 were be VBD cord-015365-iqdi99pd 2296 15 analyzed analyze VBN cord-015365-iqdi99pd 2296 16 using use VBG cord-015365-iqdi99pd 2296 17 uni uni NN cord-015365-iqdi99pd 2296 18 - - HYPH cord-015365-iqdi99pd 2296 19 and and CC cord-015365-iqdi99pd 2296 20 multivariate multivariate JJ cord-015365-iqdi99pd 2296 21 analyses analysis NNS cord-015365-iqdi99pd 2296 22 Kinder Kinder NNP cord-015365-iqdi99pd 2296 23 mit mit NNP cord-015365-iqdi99pd 2296 24 hoch hoch NNP cord-015365-iqdi99pd 2296 25 ungünstigem ungünstigem NNP cord-015365-iqdi99pd 2296 26 SVM SVM NNP cord-015365-iqdi99pd 2296 27 hatten hatten NNP cord-015365-iqdi99pd 2296 28 höhere höhere NNP cord-015365-iqdi99pd 2296 29 24h 24h NNPS cord-015365-iqdi99pd 2296 30 - - HYPH cord-015365-iqdi99pd 2296 31 RR RR NNP cord-015365-iqdi99pd 2296 32 Werte Werte NNP cord-015365-iqdi99pd 2296 33 . . . cord-015365-iqdi99pd 2297 1 Die die VB cord-015365-iqdi99pd 2297 2 RR RR NNP cord-015365-iqdi99pd 2297 3 - - HYPH cord-015365-iqdi99pd 2297 4 Differenz Differenz NNP cord-015365-iqdi99pd 2297 5 aus aus NNP cord-015365-iqdi99pd 2297 6 Klinik Klinik NNP cord-015365-iqdi99pd 2297 7 - - HYPH cord-015365-iqdi99pd 2297 8 RR RR NNP cord-015365-iqdi99pd 2297 9 und und IN cord-015365-iqdi99pd 2297 10 24hRR 24hRR NNP cord-015365-iqdi99pd 2297 11 war war NN cord-015365-iqdi99pd 2297 12 jedoch jedoch NNP cord-015365-iqdi99pd 2297 13 höher höher RBR cord-015365-iqdi99pd 2297 14 bei bei NNP cord-015365-iqdi99pd 2297 15 Kindern Kindern NNP cord-015365-iqdi99pd 2297 16 mit mit NNP cord-015365-iqdi99pd 2297 17 günstigem günstigem NNP cord-015365-iqdi99pd 2297 18 SVM SVM NNP cord-015365-iqdi99pd 2297 19 . . . cord-015365-iqdi99pd 2298 1 Es Es NNP cord-015365-iqdi99pd 2298 2 konnte konnte NNP cord-015365-iqdi99pd 2298 3 kein kein NNP cord-015365-iqdi99pd 2298 4 Zusammenhang Zusammenhang NNP cord-015365-iqdi99pd 2298 5 zwischen zwischen NNP cord-015365-iqdi99pd 2298 6 SVM SVM NNP cord-015365-iqdi99pd 2298 7 und und IN cord-015365-iqdi99pd 2298 8 Klinik Klinik NNP cord-015365-iqdi99pd 2298 9 - - HYPH cord-015365-iqdi99pd 2298 10 RR RR NNP cord-015365-iqdi99pd 2298 11 gefunden gefunden NN cord-015365-iqdi99pd 2298 12 werden werden NNP cord-015365-iqdi99pd 2298 13 . . . cord-015365-iqdi99pd 2299 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2299 2 . . . cord-015365-iqdi99pd 2300 1 Unsere Unsere NNP cord-015365-iqdi99pd 2300 2 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2300 3 zeigen zeigen NNP cord-015365-iqdi99pd 2300 4 , , , cord-015365-iqdi99pd 2300 5 dass dass NNP cord-015365-iqdi99pd 2300 6 Stressverarbeitungsmechanismen Stressverarbeitungsmechanismen NNP cord-015365-iqdi99pd 2300 7 bei bei NNP cord-015365-iqdi99pd 2300 8 der der NNP cord-015365-iqdi99pd 2300 9 Blutdruck Blutdruck NNP cord-015365-iqdi99pd 2300 10 - - HYPH cord-015365-iqdi99pd 2300 11 Regulation Regulation NNP cord-015365-iqdi99pd 2300 12 nach nach NN cord-015365-iqdi99pd 2300 13 NTX NTX NNP cord-015365-iqdi99pd 2301 1 eine eine NNP cord-015365-iqdi99pd 2301 2 Rolle Rolle NNP cord-015365-iqdi99pd 2301 3 spielen spielen NNP cord-015365-iqdi99pd 2301 4 Attitude Attitude NNP cord-015365-iqdi99pd 2301 5 towards towards IN cord-015365-iqdi99pd 2301 6 xenotransplantation xenotransplantation NN cord-015365-iqdi99pd 2301 7 of of IN cord-015365-iqdi99pd 2301 8 patients patient NNS cord-015365-iqdi99pd 2301 9 prior prior RB cord-015365-iqdi99pd 2301 10 and and CC cord-015365-iqdi99pd 2301 11 after after IN cord-015365-iqdi99pd 2301 12 human human JJ cord-015365-iqdi99pd 2301 13 organ organ NN cord-015365-iqdi99pd 2301 14 transplantation transplantation NN cord-015365-iqdi99pd 2301 15 V V NNP cord-015365-iqdi99pd 2301 16 53 53 CD cord-015365-iqdi99pd 2302 1 I -PRON- PRP cord-015365-iqdi99pd 2303 1 Iberer Iberer NNP cord-015365-iqdi99pd 2303 2 , , , cord-015365-iqdi99pd 2303 3 F. F. NNP cord-015365-iqdi99pd 2303 4 30 30 CD cord-015365-iqdi99pd 2303 5 43 43 CD cord-015365-iqdi99pd 2303 6 Ö Ö NNP cord-015365-iqdi99pd 2303 7 ttl ttl NN cord-015365-iqdi99pd 2303 8 , , , cord-015365-iqdi99pd 2303 9 K. K. NNP cord-015365-iqdi99pd 2303 10 41 41 CD cord-015365-iqdi99pd 2303 11 P p NN cord-015365-iqdi99pd 2303 12 Pacini Pacini NNP cord-015365-iqdi99pd 2303 13 Druck Druck NNP cord-015365-iqdi99pd 2303 14 : : : cord-015365-iqdi99pd 2303 15 Holzhausen Holzhausen NNP cord-015365-iqdi99pd 2303 16 Druck Druck NNP cord-015365-iqdi99pd 2303 17 GmbH GmbH NNP cord-015365-iqdi99pd 2303 18 , , , cord-015365-iqdi99pd 2303 19 1140 1140 CD cord-015365-iqdi99pd 2303 20 Wien Wien NNP cord-015365-iqdi99pd 2303 21 Ö Ö NNP cord-015365-iqdi99pd 2303 22 sterreich sterreich NN cord-015365-iqdi99pd 2303 23 . . . cord-015365-iqdi99pd 2304 1 -Verlagsort -Verlagsort : cord-015365-iqdi99pd 2304 2 : : : cord-015365-iqdi99pd 2305 1 Wien Wien NNP cord-015365-iqdi99pd 2305 2 . . . cord-015365-iqdi99pd 2306 1 -Herstellungsort -Herstellungsort : cord-015365-iqdi99pd 2306 2 : : : cord-015365-iqdi99pd 2306 3 Wien Wien NNP cord-015365-iqdi99pd 2306 4 . . . cord-015365-iqdi99pd 2307 1 Printed print VBN cord-015365-iqdi99pd 2307 2 in in IN cord-015365-iqdi99pd 2307 3 Austria Austria NNP cord-015365-iqdi99pd 2308 1 P. P. NNP cord-015365-iqdi99pd 2308 2 b. b. NNP cord-015365-iqdi99pd 2308 3 b.= b.= NNP cord-015365-iqdi99pd 2308 4 = = SYM cord-015365-iqdi99pd 2308 5 Erscheinungsort Erscheinungsort NNP cord-015365-iqdi99pd 2308 6 : : : cord-015365-iqdi99pd 2309 1 Wien= wien= NN cord-015365-iqdi99pd 2309 2 = = . cord-015365-iqdi99pd 2310 1 Verlagspostamt Verlagspostamt NNP cord-015365-iqdi99pd 2310 2 1201 1201 CD cord-015365-iqdi99pd 2311 1 Wien Wien NNP cord-015365-iqdi99pd 2311 2 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2311 3 . . . cord-015365-iqdi99pd 2312 1 Unter Unter NNP cord-015365-iqdi99pd 2312 2 konsequenter konsequenter NNP cord-015365-iqdi99pd 2312 3 systemischer systemischer NNP cord-015365-iqdi99pd 2313 1 und und NNP cord-015365-iqdi99pd 2314 1 topischer topischer NNP cord-015365-iqdi99pd 2314 2 Therapie Therapie NNP cord-015365-iqdi99pd 2314 3 mit mit NNP cord-015365-iqdi99pd 2314 4 liposomalem liposomalem NN cord-015365-iqdi99pd 2314 5 Amphotericin Amphotericin NNP cord-015365-iqdi99pd 2314 6 B B NNP cord-015365-iqdi99pd 2314 7 gefolgt gefolgt NNP cord-015365-iqdi99pd 2314 8 von von NNP cord-015365-iqdi99pd 2314 9 Voriconazol Voriconazol NNP cord-015365-iqdi99pd 2314 10 , , , cord-015365-iqdi99pd 2314 11 und und IN cord-015365-iqdi99pd 2314 12 Reduktion Reduktion NNP cord-015365-iqdi99pd 2314 13 der der NNP cord-015365-iqdi99pd 2314 14 Immunosuppression Immunosuppression NNP cord-015365-iqdi99pd 2314 15 ( ( -LRB- cord-015365-iqdi99pd 2314 16 Tacrolimusspiegel Tacrolimusspiegel NNP cord-015365-iqdi99pd 2314 17 um um UH cord-015365-iqdi99pd 2314 18 10 10 CD cord-015365-iqdi99pd 2314 19 ng ng NN cord-015365-iqdi99pd 2314 20 / / SYM cord-015365-iqdi99pd 2314 21 ml ml XX cord-015365-iqdi99pd 2314 22 , , , cord-015365-iqdi99pd 2314 23 Cortison Cortison NNP cord-015365-iqdi99pd 2314 24 10 10 CD cord-015365-iqdi99pd 2314 25 mg mg NNP cord-015365-iqdi99pd 2314 26 ) ) -RRB- cord-015365-iqdi99pd 2315 1 , , , cord-015365-iqdi99pd 2315 2 war war NN cord-015365-iqdi99pd 2315 3 die die VBP cord-015365-iqdi99pd 2315 4 Pneumonie Pneumonie NNP cord-015365-iqdi99pd 2315 5 rückläufig rückläufig NN cord-015365-iqdi99pd 2315 6 bis bis NNP cord-015365-iqdi99pd 2315 7 zum zum NNP cord-015365-iqdi99pd 2315 8 9 9 CD cord-015365-iqdi99pd 2315 9 . . . cord-015365-iqdi99pd 2316 1 po po NNP cord-015365-iqdi99pd 2316 2 . . . cord-015365-iqdi99pd 2317 1 Monat Monat NNP cord-015365-iqdi99pd 2317 2 . . . cord-015365-iqdi99pd 2318 1 I -PRON- PRP cord-015365-iqdi99pd 2319 1 m m NNP cord-015365-iqdi99pd 2319 2 12 12 CD cord-015365-iqdi99pd 2319 3 . . . cord-015365-iqdi99pd 2320 1 po po NNP cord-015365-iqdi99pd 2320 2 . . . cord-015365-iqdi99pd 2321 1 Monat Monat NNP cord-015365-iqdi99pd 2321 2 ist ist NNP cord-015365-iqdi99pd 2321 3 die die VBP cord-015365-iqdi99pd 2321 4 Patientin Patientin NNP cord-015365-iqdi99pd 2321 5 in in IN cord-015365-iqdi99pd 2321 6 gutem gutem NNP cord-015365-iqdi99pd 2321 7 Allgemeinzustand Allgemeinzustand NNP cord-015365-iqdi99pd 2321 8 mit mit NNP cord-015365-iqdi99pd 2321 9 klinisch klinisch NNP cord-015365-iqdi99pd 2321 10 - - HYPH cord-015365-iqdi99pd 2321 11 bioptisch bioptisch JJ cord-015365-iqdi99pd 2321 12 bestätigter bestätigter NNP cord-015365-iqdi99pd 2321 13 stabiler stabiler NNP cord-015365-iqdi99pd 2321 14 Transplantatfunktion Transplantatfunktion NNP cord-015365-iqdi99pd 2321 15 , , , cord-015365-iqdi99pd 2321 16 ausreichender ausreichender NNP cord-015365-iqdi99pd 2321 17 oraler oraler NNP cord-015365-iqdi99pd 2321 18 Ernährung Ernährung NNP cord-015365-iqdi99pd 2321 19 , , , cord-015365-iqdi99pd 2321 20 stabilem stabilem NNP cord-015365-iqdi99pd 2321 21 Körpergewicht Körpergewicht NNP cord-015365-iqdi99pd 2321 22 , , , cord-015365-iqdi99pd 2322 1 normaler normaler NNP cord-015365-iqdi99pd 2322 2 Leukozytenzahl Leukozytenzahl NNP cord-015365-iqdi99pd 2322 3 nach nach NNP cord-015365-iqdi99pd 2322 4 beherrschten beherrschten NNP cord-015365-iqdi99pd 2323 1 Infektionen Infektionen NNP cord-015365-iqdi99pd 2323 2 ( ( -LRB- cord-015365-iqdi99pd 2323 3 Zystitis Zystitis NNP cord-015365-iqdi99pd 2323 4 , , , cord-015365-iqdi99pd 2323 5 Lidabszeß Lidabszeß NNP cord-015365-iqdi99pd 2323 6 , , , cord-015365-iqdi99pd 2323 7 Herpesstomatitis).Schlussfolgerungen Herpesstomatitis).Schlussfolgerungen NNP cord-015365-iqdi99pd 2323 8 . . . cord-015365-iqdi99pd 2324 1 Unter unter JJ cord-015365-iqdi99pd 2324 2 sorgfältiger sorgfältiger NNP cord-015365-iqdi99pd 2324 3 Anpassung Anpassung NNP cord-015365-iqdi99pd 2324 4 der der NNP cord-015365-iqdi99pd 2324 5 Immunosuppression Immunosuppression NNP cord-015365-iqdi99pd 2325 1 und und IN cord-015365-iqdi99pd 2325 2 konsequenter konsequenter NNP cord-015365-iqdi99pd 2325 3 antimikrobieller antimikrobieller NNP cord-015365-iqdi99pd 2325 4 Therapie Therapie NNP cord-015365-iqdi99pd 2325 5 konnten konnten NNP cord-015365-iqdi99pd 2326 1 eine eine NNP cord-015365-iqdi99pd 2326 2 stabile stabile NNP cord-015365-iqdi99pd 2326 3 Transplantatfunktion Transplantatfunktion NNP cord-015365-iqdi99pd 2326 4 und und IN cord-015365-iqdi99pd 2326 5 Lebensqualität Lebensqualität NNP cord-015365-iqdi99pd 2326 6 erreicht erreicht JJ cord-015365-iqdi99pd 2326 7 werden werden NNP cord-015365-iqdi99pd 2326 8 nach nach NNP cord-015365-iqdi99pd 2326 9 schwerer schwerer NNP cord-015365-iqdi99pd 2326 10 akuter akuter NNP cord-015365-iqdi99pd 2326 11 Abstoßungsreaktion Abstoßungsreaktion NNP cord-015365-iqdi99pd 2326 12 , , , cord-015365-iqdi99pd 2326 13 CMV CMV NNP cord-015365-iqdi99pd 2326 14 - - HYPH cord-015365-iqdi99pd 2326 15 Transplantatenteritis Transplantatenteritis NNP cord-015365-iqdi99pd 2326 16 und und IN cord-015365-iqdi99pd 2326 17 Aspergilluspneumonie Aspergilluspneumonie NNP cord-015365-iqdi99pd 2326 18 . . . cord-015365-iqdi99pd 2327 1 Bullous Bullous NNP cord-015365-iqdi99pd 2327 2 pemphigoid pemphigoid NNP cord-015365-iqdi99pd 2327 3 11 11 CD cord-015365-iqdi99pd 2327 4 years year NNS cord-015365-iqdi99pd 2327 5 after after IN cord-015365-iqdi99pd 2327 6 bilateral bilateral JJ cord-015365-iqdi99pd 2327 7 hand hand NN cord-015365-iqdi99pd 2327 8 transplantation transplantation NN cord-015365-iqdi99pd 2327 9 _SP cord-015365-iqdi99pd 2328 1 Background background NN cord-015365-iqdi99pd 2328 2 . . . cord-015365-iqdi99pd 2329 1 Expression expression NN cord-015365-iqdi99pd 2329 2 of of IN cord-015365-iqdi99pd 2329 3 peripheral peripheral JJ cord-015365-iqdi99pd 2329 4 - - HYPH cord-015365-iqdi99pd 2329 5 node node NN cord-015365-iqdi99pd 2329 6 - - HYPH cord-015365-iqdi99pd 2329 7 addressin addressin NNP cord-015365-iqdi99pd 2329 8 ( ( -LRB- cord-015365-iqdi99pd 2329 9 PNAd PNAd NNS cord-015365-iqdi99pd 2329 10 ) ) -RRB- cord-015365-iqdi99pd 2329 11 on on IN cord-015365-iqdi99pd 2329 12 endothelial endothelial JJ cord-015365-iqdi99pd 2329 13 cells cell NNS cord-015365-iqdi99pd 2329 14 indicates indicate VBZ cord-015365-iqdi99pd 2329 15 presence presence NN cord-015365-iqdi99pd 2329 16 of of IN cord-015365-iqdi99pd 2329 17 tertiary tertiary JJ cord-015365-iqdi99pd 2329 18 lymphoid lymphoid JJ cord-015365-iqdi99pd 2329 19 organs organ NNS cord-015365-iqdi99pd 2329 20 ( ( -LRB- cord-015365-iqdi99pd 2329 21 TLO TLO NNP cord-015365-iqdi99pd 2329 22 ) ) -RRB- cord-015365-iqdi99pd 2329 23 in in IN cord-015365-iqdi99pd 2329 24 chronic chronic JJ cord-015365-iqdi99pd 2329 25 autoimmunity autoimmunity NN cord-015365-iqdi99pd 2329 26 and and CC cord-015365-iqdi99pd 2329 27 allograft allograft NN cord-015365-iqdi99pd 2329 28 rejection rejection NN cord-015365-iqdi99pd 2329 29 . . . cord-015365-iqdi99pd 2330 1 We -PRON- PRP cord-015365-iqdi99pd 2330 2 herein herein RB cord-015365-iqdi99pd 2330 3 investigated investigate VBD cord-015365-iqdi99pd 2330 4 the the DT cord-015365-iqdi99pd 2330 5 expression expression NN cord-015365-iqdi99pd 2330 6 of of IN cord-015365-iqdi99pd 2330 7 PNAd PNAd NNS cord-015365-iqdi99pd 2330 8 in in IN cord-015365-iqdi99pd 2330 9 skin skin NN cord-015365-iqdi99pd 2330 10 biopsies biopsy NNS cord-015365-iqdi99pd 2330 11 of of IN cord-015365-iqdi99pd 2330 12 human human JJ cord-015365-iqdi99pd 2330 13 hand hand NN cord-015365-iqdi99pd 2330 14 allografts allograft NNS cord-015365-iqdi99pd 2330 15 for for IN cord-015365-iqdi99pd 2330 16 evidence evidence NN cord-015365-iqdi99pd 2330 17 of of IN cord-015365-iqdi99pd 2330 18 TLO TLO NNP cord-015365-iqdi99pd 2330 19 after after IN cord-015365-iqdi99pd 2330 20 composite composite JJ cord-015365-iqdi99pd 2330 21 tissue tissue NN cord-015365-iqdi99pd 2330 22 allotransplantation allotransplantation NN cord-015365-iqdi99pd 2330 23 . . . cord-015365-iqdi99pd 2331 1 Methods method NNS cord-015365-iqdi99pd 2331 2 . . . cord-015365-iqdi99pd 2332 1 167 167 CD cord-015365-iqdi99pd 2332 2 skin skin NN cord-015365-iqdi99pd 2332 3 biopsies biopsy NNS cord-015365-iqdi99pd 2332 4 of of IN cord-015365-iqdi99pd 2332 5 11 11 CD cord-015365-iqdi99pd 2332 6 hand hand NN cord-015365-iqdi99pd 2332 7 allografts allograft NNS cord-015365-iqdi99pd 2332 8 were be VBD cord-015365-iqdi99pd 2332 9 collected collect VBN cord-015365-iqdi99pd 2332 10 over over IN cord-015365-iqdi99pd 2332 11 10 10 CD cord-015365-iqdi99pd 2332 12 years year NNS cord-015365-iqdi99pd 2332 13 and and CC cord-015365-iqdi99pd 2332 14 assessed assess VBN cord-015365-iqdi99pd 2332 15 by by IN cord-015365-iqdi99pd 2332 16 HE HE NNP cord-015365-iqdi99pd 2332 17 - - HYPH cord-015365-iqdi99pd 2332 18 histology histology NN cord-015365-iqdi99pd 2332 19 and and CC cord-015365-iqdi99pd 2332 20 immunohistochemistry immunohistochemistry NN cord-015365-iqdi99pd 2332 21 using use VBG cord-015365-iqdi99pd 2332 22 antibodies antibody NNS cord-015365-iqdi99pd 2332 23 for for IN cord-015365-iqdi99pd 2332 24 PNAd PNAd NNS cord-015365-iqdi99pd 2332 25 , , , cord-015365-iqdi99pd 2332 26 CD3 CD3 NNP cord-015365-iqdi99pd 2332 27 , , , cord-015365-iqdi99pd 2332 28 CD4 CD4 NNP cord-015365-iqdi99pd 2332 29 , , , cord-015365-iqdi99pd 2332 30 CD8 CD8 NNP cord-015365-iqdi99pd 2332 31 , , , cord-015365-iqdi99pd 2332 32 CD20 CD20 NNP cord-015365-iqdi99pd 2332 33 , , , cord-015365-iqdi99pd 2332 34 C4d C4d NNP cord-015365-iqdi99pd 2332 35 , , , cord-015365-iqdi99pd 2332 36 CD68 CD68 NNP cord-015365-iqdi99pd 2332 37 , , , cord-015365-iqdi99pd 2332 38 LFA-1 LFA-1 NNP cord-015365-iqdi99pd 2332 39 , , , cord-015365-iqdi99pd 2332 40 ICAM-1 ICAM-1 NNP cord-015365-iqdi99pd 2332 41 , , , cord-015365-iqdi99pd 2332 42 E e NN cord-015365-iqdi99pd 2332 43 - - NN cord-015365-iqdi99pd 2332 44 selectin selectin JJ cord-015365-iqdi99pd 2332 45 , , , cord-015365-iqdi99pd 2332 46 P p NN cord-015365-iqdi99pd 2332 47 - - HYPH cord-015365-iqdi99pd 2332 48 selectin selectin NNP cord-015365-iqdi99pd 2332 49 , , , cord-015365-iqdi99pd 2332 50 VE VE NNP cord-015365-iqdi99pd 2332 51 - - HYPH cord-015365-iqdi99pd 2332 52 cadherin cadherin NN cord-015365-iqdi99pd 2332 53 , , , cord-015365-iqdi99pd 2332 54 HLA HLA NNP cord-015365-iqdi99pd 2332 55 - - HYPH cord-015365-iqdi99pd 2332 56 DR DR NNP cord-015365-iqdi99pd 2332 57 , , , cord-015365-iqdi99pd 2332 58 Psoriasin Psoriasin NNP cord-015365-iqdi99pd 2332 59 , , , cord-015365-iqdi99pd 2332 60 IDO IDO NNP cord-015365-iqdi99pd 2332 61 and and CC cord-015365-iqdi99pd 2332 62 Foxp3 Foxp3 NNP cord-015365-iqdi99pd 2332 63 . . . cord-015365-iqdi99pd 2333 1 Levels level NNS cord-015365-iqdi99pd 2333 2 of of IN cord-015365-iqdi99pd 2333 3 PNAd PNAd NNS cord-015365-iqdi99pd 2333 4 expression expression NN cord-015365-iqdi99pd 2333 5 was be VBD cord-015365-iqdi99pd 2333 6 assessed assess VBN cord-015365-iqdi99pd 2333 7 semiquantitatively semiquantitatively NNP cord-015365-iqdi99pd 2333 8 ( ( -LRB- cord-015365-iqdi99pd 2333 9 % % NN cord-015365-iqdi99pd 2333 10 of of IN cord-015365-iqdi99pd 2333 11 PNAdþ PNAdþ NNP cord-015365-iqdi99pd 2333 12 vessels vessel NNS cord-015365-iqdi99pd 2333 13 : : : cord-015365-iqdi99pd 2333 14 0 0 CD cord-015365-iqdi99pd 2333 15 , , , cord-015365-iqdi99pd 2333 16 1 1 CD cord-015365-iqdi99pd 2333 17 , , , cord-015365-iqdi99pd 2333 18 2 2 CD cord-015365-iqdi99pd 2333 19 , , , cord-015365-iqdi99pd 2333 20 3 3 CD cord-015365-iqdi99pd 2333 21 and and CC cord-015365-iqdi99pd 2333 22 PNAd PNAd NNS cord-015365-iqdi99pd 2333 23 staining stain VBG cord-015365-iqdi99pd 2333 24 intensity intensity NN cord-015365-iqdi99pd 2333 25 : : : cord-015365-iqdi99pd 2333 26 0 0 CD cord-015365-iqdi99pd 2333 27 , , , cord-015365-iqdi99pd 2333 28 1 1 CD cord-015365-iqdi99pd 2333 29 , , , cord-015365-iqdi99pd 2333 30 2 2 CD cord-015365-iqdi99pd 2333 31 , , , cord-015365-iqdi99pd 2333 32 3 3 CD cord-015365-iqdi99pd 2333 33 ) ) -RRB- cord-015365-iqdi99pd 2333 34 and and CC cord-015365-iqdi99pd 2333 35 correlated correlate VBD cord-015365-iqdi99pd 2333 36 with with IN cord-015365-iqdi99pd 2333 37 rejection rejection NN cord-015365-iqdi99pd 2333 38 grade grade NN cord-015365-iqdi99pd 2333 39 , , , cord-015365-iqdi99pd 2333 40 characterization characterization NN cord-015365-iqdi99pd 2333 41 of of IN cord-015365-iqdi99pd 2333 42 the the DT cord-015365-iqdi99pd 2333 43 infiltrate infiltrate NN cord-015365-iqdi99pd 2333 44 , , , cord-015365-iqdi99pd 2333 45 expression expression NN cord-015365-iqdi99pd 2333 46 of of IN cord-015365-iqdi99pd 2333 47 adhesion adhesion NN cord-015365-iqdi99pd 2333 48 molecules molecule NNS cord-015365-iqdi99pd 2333 49 and and CC cord-015365-iqdi99pd 2333 50 time time NN cord-015365-iqdi99pd 2333 51 after after IN cord-015365-iqdi99pd 2333 52 transplantation transplantation NN cord-015365-iqdi99pd 2333 53 . . . cord-015365-iqdi99pd 2334 1 Results result NNS cord-015365-iqdi99pd 2334 2 . . . cord-015365-iqdi99pd 2335 1 Rejection rejection NN cord-015365-iqdi99pd 2335 2 ranged range VBD cord-015365-iqdi99pd 2335 3 from from IN cord-015365-iqdi99pd 2335 4 grade grade NN cord-015365-iqdi99pd 2335 5 0 0 CD cord-015365-iqdi99pd 2335 6 to to IN cord-015365-iqdi99pd 2335 7 IV IV NNP cord-015365-iqdi99pd 2336 1 ( ( -LRB- cord-015365-iqdi99pd 2336 2 mean mean VB cord-015365-iqdi99pd 2336 3 score score NN cord-015365-iqdi99pd 2336 4 : : : cord-015365-iqdi99pd 2336 5 0.79 0.79 CD cord-015365-iqdi99pd 2336 6 AE AE NNP cord-015365-iqdi99pd 2336 7 1.05 1.05 CD cord-015365-iqdi99pd 2336 8 ) ) -RRB- cord-015365-iqdi99pd 2336 9 . . . cord-015365-iqdi99pd 2337 1 Upon upon IN cord-015365-iqdi99pd 2337 2 rejection rejection NN cord-015365-iqdi99pd 2337 3 , , , cord-015365-iqdi99pd 2337 4 expression expression NN cord-015365-iqdi99pd 2337 5 of of IN cord-015365-iqdi99pd 2337 6 PNAd PNAd NNS cord-015365-iqdi99pd 2337 7 was be VBD cord-015365-iqdi99pd 2337 8 increased increase VBN cord-015365-iqdi99pd 2337 9 in in IN cord-015365-iqdi99pd 2337 10 endothelial endothelial JJ cord-015365-iqdi99pd 2337 11 cells cell NNS cord-015365-iqdi99pd 2337 12 ( ( -LRB- cord-015365-iqdi99pd 2337 13 grade grade NN cord-015365-iqdi99pd 2337 14 0 0 CD cord-015365-iqdi99pd 2337 15 : : : cord-015365-iqdi99pd 2337 16 0.24 0.24 CD cord-015365-iqdi99pd 2337 17 AE AE NNP cord-015365-iqdi99pd 2337 18 0.48 0.48 CD cord-015365-iqdi99pd 2337 19 vs. vs. IN cord-015365-iqdi99pd 2337 20 all all DT cord-015365-iqdi99pd 2337 21 grades grade NNS cord-015365-iqdi99pd 2337 22 of of IN cord-015365-iqdi99pd 2337 23 rejection rejection NN cord-015365-iqdi99pd 2337 24 : : : cord-015365-iqdi99pd 2337 25 0.44 0.44 CD cord-015365-iqdi99pd 2337 26 AE AE NNP cord-015365-iqdi99pd 2337 27 0.62 0.62 CD cord-015365-iqdi99pd 2337 28 ) ) -RRB- cord-015365-iqdi99pd 2337 29 . . . cord-015365-iqdi99pd 2338 1 Most most RBS cord-015365-iqdi99pd 2338 2 often often RB cord-015365-iqdi99pd 2338 3 PNAd PNAd VBZ cord-015365-iqdi99pd 2338 4 expression expression NN cord-015365-iqdi99pd 2338 5 was be VBD cord-015365-iqdi99pd 2338 6 only only RB cord-015365-iqdi99pd 2338 7 found find VBN cord-015365-iqdi99pd 2338 8 in in IN cord-015365-iqdi99pd 2338 9 few few JJ cord-015365-iqdi99pd 2338 10 vessels vessel NNS cord-015365-iqdi99pd 2338 11 ( ( -LRB- cord-015365-iqdi99pd 2338 12 1 1 CD cord-015365-iqdi99pd 2338 13 - - SYM cord-015365-iqdi99pd 2338 14 10 10 CD cord-015365-iqdi99pd 2338 15 % % NN cord-015365-iqdi99pd 2338 16 ) ) -RRB- cord-015365-iqdi99pd 2338 17 . . . cord-015365-iqdi99pd 2339 1 PNAd PNAd NNS cord-015365-iqdi99pd 2339 2 staining stain VBG cord-015365-iqdi99pd 2339 3 intensity intensity NN cord-015365-iqdi99pd 2339 4 was be VBD cord-015365-iqdi99pd 2339 5 increased increase VBN cord-015365-iqdi99pd 2339 6 the the DT cord-015365-iqdi99pd 2339 7 higher high JJR cord-015365-iqdi99pd 2339 8 the the DT cord-015365-iqdi99pd 2339 9 grade grade NN cord-015365-iqdi99pd 2339 10 of of IN cord-015365-iqdi99pd 2339 11 rejection rejection NN cord-015365-iqdi99pd 2339 12 ( ( -LRB- cord-015365-iqdi99pd 2339 13 grade grade NN cord-015365-iqdi99pd 2339 14 0 0 CD cord-015365-iqdi99pd 2339 15 : : : cord-015365-iqdi99pd 2339 16 0.38 0.38 CD cord-015365-iqdi99pd 2339 17 AE AE NNP cord-015365-iqdi99pd 2339 18 0.76 0.76 CD cord-015365-iqdi99pd 2339 19 ; ; : cord-015365-iqdi99pd 2339 20 grade grade NN cord-015365-iqdi99pd 2339 21 I -PRON- PRP cord-015365-iqdi99pd 2339 22 : : : cord-015365-iqdi99pd 2339 23 0.41 0.41 CD cord-015365-iqdi99pd 2339 24 AE AE NNP cord-015365-iqdi99pd 2339 25 0.74 0.74 CD cord-015365-iqdi99pd 2339 26 ; ; : cord-015365-iqdi99pd 2339 27 grade grade NN cord-015365-iqdi99pd 2339 28 II II NNP cord-015365-iqdi99pd 2339 29 : : : cord-015365-iqdi99pd 2339 30 0.67 0.67 CD cord-015365-iqdi99pd 2339 31 AE AE NNP cord-015365-iqdi99pd 2339 32 0.80 0.80 CD cord-015365-iqdi99pd 2339 33 ; ; : cord-015365-iqdi99pd 2339 34 grade grade NN cord-015365-iqdi99pd 2339 35 III III NNP cord-015365-iqdi99pd 2339 36 : : : cord-015365-iqdi99pd 2339 37 0.73 0.73 CD cord-015365-iqdi99pd 2339 38 AE AE NNP cord-015365-iqdi99pd 2339 39 0.91 0.91 CD cord-015365-iqdi99pd 2339 40 ; ; : cord-015365-iqdi99pd 2339 41 grade grade NN cord-015365-iqdi99pd 2339 42 IV IV NNP cord-015365-iqdi99pd 2339 43 : : : cord-015365-iqdi99pd 2339 44 0.50 0.50 CD cord-015365-iqdi99pd 2339 45 AE AE NNP cord-015365-iqdi99pd 2339 46 0.58 0.58 CD cord-015365-iqdi99pd 2339 47 ) ) -RRB- cord-015365-iqdi99pd 2339 48 . . . cord-015365-iqdi99pd 2340 1 Intense intense JJ cord-015365-iqdi99pd 2340 2 PNAd PNAd NNS cord-015365-iqdi99pd 2340 3 - - : cord-015365-iqdi99pd 2340 4 staining staining NN cord-015365-iqdi99pd 2340 5 was be VBD cord-015365-iqdi99pd 2340 6 associated associate VBN cord-015365-iqdi99pd 2340 7 with with IN cord-015365-iqdi99pd 2340 8 more more JJR cord-015365-iqdi99pd 2340 9 CD4þ CD4þ NNP cord-015365-iqdi99pd 2340 10 and and CC cord-015365-iqdi99pd 2340 11 CD8 CD8 NNP cord-015365-iqdi99pd 2340 12 þ þ NNP cord-015365-iqdi99pd 2340 13 infiltrating infiltrate VBG cord-015365-iqdi99pd 2340 14 T t NN cord-015365-iqdi99pd 2340 15 - - HYPH cord-015365-iqdi99pd 2340 16 cells cell NNS cord-015365-iqdi99pd 2340 17 , , , cord-015365-iqdi99pd 2340 18 but but CC cord-015365-iqdi99pd 2340 19 less less JJR cord-015365-iqdi99pd 2340 20 B b NN cord-015365-iqdi99pd 2340 21 - - HYPH cord-015365-iqdi99pd 2340 22 cells cell NNS cord-015365-iqdi99pd 2340 23 and and CC cord-015365-iqdi99pd 2340 24 macrophages macrophage NNS cord-015365-iqdi99pd 2340 25 , , , cord-015365-iqdi99pd 2340 26 compared compare VBN cord-015365-iqdi99pd 2340 27 to to IN cord-015365-iqdi99pd 2340 28 mild mild JJ cord-015365-iqdi99pd 2340 29 PNAd PNAd NNS cord-015365-iqdi99pd 2340 30 staining stain VBG cord-015365-iqdi99pd 2340 31 intensity intensity NN cord-015365-iqdi99pd 2340 32 ( ( -LRB- cord-015365-iqdi99pd 2340 33 CD4 CD4 NNP cord-015365-iqdi99pd 2340 34 þ þ NNP cord-015365-iqdi99pd 2340 35 cells cell NNS cord-015365-iqdi99pd 2340 36 49.00 49.00 CD cord-015365-iqdi99pd 2340 37 % % NN cord-015365-iqdi99pd 2340 38 AE AE NNP cord-015365-iqdi99pd 2340 39 29.89 29.89 CD cord-015365-iqdi99pd 2340 40 % % NN cord-015365-iqdi99pd 2340 41 ; ; : cord-015365-iqdi99pd 2340 42 CD8 CD8 NNP cord-015365-iqdi99pd 2340 43 þ þ NNP cord-015365-iqdi99pd 2340 44 cells cell NNS cord-015365-iqdi99pd 2340 45 31.00 31.00 CD cord-015365-iqdi99pd 2340 46 % % NN cord-015365-iqdi99pd 2340 47 AE AE NNP cord-015365-iqdi99pd 2340 48 22.34 22.34 CD cord-015365-iqdi99pd 2340 49 % % NN cord-015365-iqdi99pd 2340 50 ; ; . cord-015365-iqdi99pd 2341 1 CD20 CD20 NNP cord-015365-iqdi99pd 2341 2 þ þ NNP cord-015365-iqdi99pd 2341 3 B b NN cord-015365-iqdi99pd 2341 4 - - HYPH cord-015365-iqdi99pd 2341 5 cells cell NNS cord-015365-iqdi99pd 2341 6 0.50 0.50 CD cord-015365-iqdi99pd 2341 7 % % NN cord-015365-iqdi99pd 2341 8 AE AE NNP cord-015365-iqdi99pd 2341 9 1.54 1.54 CD cord-015365-iqdi99pd 2341 10 % % NN cord-015365-iqdi99pd 2341 11 ; ; : cord-015365-iqdi99pd 2341 12 CD68 CD68 NNP cord-015365-iqdi99pd 2341 13 þ þ NNP cord-015365-iqdi99pd 2341 14 macrophages macrophage VBZ cord-015365-iqdi99pd 2341 15 0.57 0.57 CD cord-015365-iqdi99pd 2341 16 AE AE NNP cord-015365-iqdi99pd 2341 17 0.60 0.60 CD cord-015365-iqdi99pd 2341 18 vs. vs. NN cord-015365-iqdi99pd 2342 1 CD4 CD4 NNP cord-015365-iqdi99pd 2342 2 þ þ NNP cord-015365-iqdi99pd 2342 3 cells cell VBZ cord-015365-iqdi99pd 2342 4 37.35 37.35 CD cord-015365-iqdi99pd 2342 5 % % NN cord-015365-iqdi99pd 2342 6 AE AE NNP cord-015365-iqdi99pd 2342 7 40.82 40.82 CD cord-015365-iqdi99pd 2342 8 % % NN cord-015365-iqdi99pd 2342 9 ; ; : cord-015365-iqdi99pd 2342 10 CD8þcells CD8þcells NNP cord-015365-iqdi99pd 2342 11 27.35 27.35 CD cord-015365-iqdi99pd 2342 12 % % NN cord-015365-iqdi99pd 2342 13 AE AE NNP cord-015365-iqdi99pd 2342 14 35.93 35.93 CD cord-015365-iqdi99pd 2342 15 % % NN cord-015365-iqdi99pd 2342 16 ; ; : cord-015365-iqdi99pd 2342 17 CD20 cd20 NN cord-015365-iqdi99pd 2342 18 þ þ NNP cord-015365-iqdi99pd 2342 19 B b NN cord-015365-iqdi99pd 2342 20 - - HYPH cord-015365-iqdi99pd 2342 21 cells cell NNS cord-015365-iqdi99pd 2343 1 0.94 0.94 CD cord-015365-iqdi99pd 2343 2 % % NN cord-015365-iqdi99pd 2343 3 AE AE NNP cord-015365-iqdi99pd 2343 4 2.02 2.02 CD cord-015365-iqdi99pd 2343 5 % % NN cord-015365-iqdi99pd 2343 6 ; ; : cord-015365-iqdi99pd 2343 7 CD68þmacrophages cd68þmacrophage VBZ cord-015365-iqdi99pd 2343 8 0.67 0.67 CD cord-015365-iqdi99pd 2343 9 AE AE NNP cord-015365-iqdi99pd 2343 10 0.66 0.66 CD cord-015365-iqdi99pd 2343 11 ) ) -RRB- cord-015365-iqdi99pd 2343 12 . . . cord-015365-iqdi99pd 2344 1 PNAd PNAd NNS cord-015365-iqdi99pd 2344 2 expression expression NN cord-015365-iqdi99pd 2344 3 correlated correlate VBD cord-015365-iqdi99pd 2344 4 well well RB cord-015365-iqdi99pd 2344 5 with with IN cord-015365-iqdi99pd 2344 6 CD3þcells CD3þcells NNP cord-015365-iqdi99pd 2344 7 and and CC cord-015365-iqdi99pd 2344 8 CD20þBcells cd20þbcell NNS cord-015365-iqdi99pd 2344 9 . . . cord-015365-iqdi99pd 2345 1 Poor poor JJ cord-015365-iqdi99pd 2345 2 correlation correlation NN cord-015365-iqdi99pd 2345 3 was be VBD cord-015365-iqdi99pd 2345 4 found find VBN cord-015365-iqdi99pd 2345 5 for for IN cord-015365-iqdi99pd 2345 6 expression expression NN cord-015365-iqdi99pd 2345 7 of of IN cord-015365-iqdi99pd 2345 8 adhesion adhesion NN cord-015365-iqdi99pd 2345 9 molecules molecule NNS cord-015365-iqdi99pd 2345 10 , , , cord-015365-iqdi99pd 2345 11 IDO IDO NNP cord-015365-iqdi99pd 2345 12 and and CC cord-015365-iqdi99pd 2345 13 Foxp3 Foxp3 NNP cord-015365-iqdi99pd 2345 14 , , , cord-015365-iqdi99pd 2345 15 except except IN cord-015365-iqdi99pd 2345 16 for for IN cord-015365-iqdi99pd 2345 17 LFA-1þ LFA-1þ NNP cord-015365-iqdi99pd 2345 18 infiltrating infiltrate VBG cord-015365-iqdi99pd 2345 19 cells cell NNS cord-015365-iqdi99pd 2345 20 . . . cord-015365-iqdi99pd 2346 1 PNAd PNAd NNS cord-015365-iqdi99pd 2346 2 expression expression NN cord-015365-iqdi99pd 2346 3 was be VBD cord-015365-iqdi99pd 2346 4 observed observe VBN cord-015365-iqdi99pd 2346 5 at at IN cord-015365-iqdi99pd 2346 6 all all DT cord-015365-iqdi99pd 2346 7 time time NN cord-015365-iqdi99pd 2346 8 - - HYPH cord-015365-iqdi99pd 2346 9 points point NNS cord-015365-iqdi99pd 2346 10 after after IN cord-015365-iqdi99pd 2346 11 transplantation transplantation NN cord-015365-iqdi99pd 2346 12 ; ; : cord-015365-iqdi99pd 2346 13 however however RB cord-015365-iqdi99pd 2346 14 , , , cord-015365-iqdi99pd 2346 15 staining stain VBG cord-015365-iqdi99pd 2346 16 intensity intensity NN cord-015365-iqdi99pd 2346 17 was be VBD cord-015365-iqdi99pd 2346 18 enhanced enhance VBN cord-015365-iqdi99pd 2346 19 very very RB cord-015365-iqdi99pd 2346 20 early early JJ cord-015365-iqdi99pd 2346 21 and and CC cord-015365-iqdi99pd 2346 22 late late JJ cord-015365-iqdi99pd 2346 23 after after IN cord-015365-iqdi99pd 2346 24 transplantation transplantation NN cord-015365-iqdi99pd 2346 25 . . . cord-015365-iqdi99pd 2347 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2347 2 . . . cord-015365-iqdi99pd 2348 1 PNAd PNAd NNS cord-015365-iqdi99pd 2348 2 expression expression NN cord-015365-iqdi99pd 2348 3 in in IN cord-015365-iqdi99pd 2348 4 endothelial endothelial JJ cord-015365-iqdi99pd 2348 5 cells cell NNS cord-015365-iqdi99pd 2348 6 is be VBZ cord-015365-iqdi99pd 2348 7 increased increase VBN cord-015365-iqdi99pd 2348 8 in in IN cord-015365-iqdi99pd 2348 9 skin skin NN cord-015365-iqdi99pd 2348 10 biopsies biopsy NNS cord-015365-iqdi99pd 2348 11 of of IN cord-015365-iqdi99pd 2348 12 human human JJ cord-015365-iqdi99pd 2348 13 hand hand NN cord-015365-iqdi99pd 2348 14 allografts allograft NNS cord-015365-iqdi99pd 2348 15 indicating indicate VBG cord-015365-iqdi99pd 2348 16 presence presence NN cord-015365-iqdi99pd 2348 17 of of IN cord-015365-iqdi99pd 2348 18 TLO TLO NNP cord-015365-iqdi99pd 2348 19 . . . cord-015365-iqdi99pd 2349 1 Further further JJ cord-015365-iqdi99pd 2349 2 investigations investigation NNS cord-015365-iqdi99pd 2349 3 are be VBP cord-015365-iqdi99pd 2349 4 needed need VBN cord-015365-iqdi99pd 2349 5 to to TO cord-015365-iqdi99pd 2349 6 enlighten enlighten VB cord-015365-iqdi99pd 2349 7 the the DT cord-015365-iqdi99pd 2349 8 role role NN cord-015365-iqdi99pd 2349 9 of of IN cord-015365-iqdi99pd 2349 10 PNAd PNAd NNS cord-015365-iqdi99pd 2349 11 and and CC cord-015365-iqdi99pd 2349 12 TLOs TLOs NNPS cord-015365-iqdi99pd 2349 13 in in IN cord-015365-iqdi99pd 2349 14 composite composite JJ cord-015365-iqdi99pd 2349 15 tissue tissue NN cord-015365-iqdi99pd 2349 16 allotransplantation allotransplantation NN cord-015365-iqdi99pd 2349 17 . . . cord-015365-iqdi99pd 2350 1 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2350 2 . . . cord-015365-iqdi99pd 2351 1 Die die VB cord-015365-iqdi99pd 2351 2 zum zum NNP cord-015365-iqdi99pd 2351 3 Hämabbau Hämabbau NNP cord-015365-iqdi99pd 2352 1 notwendige notwendige NNP cord-015365-iqdi99pd 2352 2 induzierbare induzierbare NNP cord-015365-iqdi99pd 2353 1 Hämoxygenase-1 Hämoxygenase-1 NNP cord-015365-iqdi99pd 2354 1 ( ( -LRB- cord-015365-iqdi99pd 2354 2 HO-1 HO-1 NNP cord-015365-iqdi99pd 2354 3 ) ) -RRB- cord-015365-iqdi99pd 2354 4 wirkt wirkt NNP cord-015365-iqdi99pd 2354 5 stark stark JJ cord-015365-iqdi99pd 2354 6 antiinflammatorisch antiinflammatorisch NNP cord-015365-iqdi99pd 2355 1 und und NNP cord-015365-iqdi99pd 2355 2 schützt schützt NNP cord-015365-iqdi99pd 2355 3 vor vor NNP cord-015365-iqdi99pd 2355 4 Ischämie Ischämie NNP cord-015365-iqdi99pd 2355 5 - - HYPH cord-015365-iqdi99pd 2355 6 und und NNP cord-015365-iqdi99pd 2355 7 Reperfusionsschäden Reperfusionsschäden NNP cord-015365-iqdi99pd 2355 8 ( ( -LRB- cord-015365-iqdi99pd 2355 9 IRS IRS NNP cord-015365-iqdi99pd 2355 10 ) ) -RRB- cord-015365-iqdi99pd 2355 11 . . . cord-015365-iqdi99pd 2356 1 Eine Eine NNP cord-015365-iqdi99pd 2356 2 klinische klinische NNP cord-015365-iqdi99pd 2356 3 Anwendung Anwendung NNP cord-015365-iqdi99pd 2356 4 i -PRON- PRP cord-015365-iqdi99pd 2356 5 m be VBP cord-015365-iqdi99pd 2356 6 Sinne Sinne NNP cord-015365-iqdi99pd 2357 1 einer einer NNP cord-015365-iqdi99pd 2357 2 HO-1-Induktion HO-1-Induktion NNP cord-015365-iqdi99pd 2357 3 ist ist NNP cord-015365-iqdi99pd 2357 4 aufgrund aufgrund NNP cord-015365-iqdi99pd 2357 5 der der NNP cord-015365-iqdi99pd 2357 6 Hepatotoxizität Hepatotoxizität NNP cord-015365-iqdi99pd 2357 7 der der NNP cord-015365-iqdi99pd 2357 8 experimentell experimentell NNP cord-015365-iqdi99pd 2357 9 verwendeten verwendeten NNP cord-015365-iqdi99pd 2357 10 HO-1-Induktoren HO-1-Induktoren NNP cord-015365-iqdi99pd 2357 11 nicht nicht NNP cord-015365-iqdi99pd 2357 12 möglich möglich NNP cord-015365-iqdi99pd 2357 13 . . . cord-015365-iqdi99pd 2358 1 Ziel Ziel NNP cord-015365-iqdi99pd 2358 2 der der NNP cord-015365-iqdi99pd 2358 3 Studie Studie NNP cord-015365-iqdi99pd 2358 4 war war NN cord-015365-iqdi99pd 2358 5 es es NN cord-015365-iqdi99pd 2358 6 , , , cord-015365-iqdi99pd 2358 7 natürlich natürlich NNP cord-015365-iqdi99pd 2358 8 vorkommende vorkommende NNP cord-015365-iqdi99pd 2358 9 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2358 10 auf auf NNP cord-015365-iqdi99pd 2358 11 Ihr Ihr NNP cord-015365-iqdi99pd 2358 12 Potential potential JJ cord-015365-iqdi99pd 2358 13 zur zur NN cord-015365-iqdi99pd 2358 14 HO-1 HO-1 NNP cord-015365-iqdi99pd 2358 15 Induktion Induktion NNP cord-015365-iqdi99pd 2358 16 zu zu NNP cord-015365-iqdi99pd 2358 17 untersuchen untersuchen NNP cord-015365-iqdi99pd 2358 18 . . . cord-015365-iqdi99pd 2359 1 Methodik Methodik NNP cord-015365-iqdi99pd 2359 2 . . . cord-015365-iqdi99pd 2360 1 Verschiedene Verschiedene NNP cord-015365-iqdi99pd 2360 2 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2360 3 wurden wurden VBD cord-015365-iqdi99pd 2360 4 in in IN cord-015365-iqdi99pd 2360 5 Hinblick Hinblick NNP cord-015365-iqdi99pd 2360 6 auf auf NNP cord-015365-iqdi99pd 2360 7 die die VB cord-015365-iqdi99pd 2360 8 HO-1-Induktion ho-1-induktion NN cord-015365-iqdi99pd 2360 9 mittels mittel NNS cord-015365-iqdi99pd 2360 10 PCR PCR NNP cord-015365-iqdi99pd 2360 11 getestet getestet NNP cord-015365-iqdi99pd 2360 12 . . . cord-015365-iqdi99pd 2361 1 In in IN cord-015365-iqdi99pd 2361 2 einem einem NNP cord-015365-iqdi99pd 2361 3 etablierten etablierten NNP cord-015365-iqdi99pd 2361 4 Ratten Ratten NNP cord-015365-iqdi99pd 2361 5 - - HYPH cord-015365-iqdi99pd 2361 6 Nierenarterien Nierenarterien NNP cord-015365-iqdi99pd 2361 7 - - HYPH cord-015365-iqdi99pd 2361 8 Klemmmodell Klemmmodell NNP cord-015365-iqdi99pd 2362 1 wurde wurde NNP cord-015365-iqdi99pd 2362 2 ein ein NNP cord-015365-iqdi99pd 2362 3 IRS IRS NNP cord-015365-iqdi99pd 2362 4 gesetzt gesetzt NN cord-015365-iqdi99pd 2362 5 , , , cord-015365-iqdi99pd 2362 6 Nierenfunktionsparameter Nierenfunktionsparameter NNP cord-015365-iqdi99pd 2362 7 und und XX cord-015365-iqdi99pd 2363 1 HO-1 HO-1 NNP cord-015365-iqdi99pd 2363 2 Expression Expression NNP cord-015365-iqdi99pd 2363 3 wurden wurden XX cord-015365-iqdi99pd 2364 1 zu zu NNP cord-015365-iqdi99pd 2364 2 festgelegten festgelegten NNP cord-015365-iqdi99pd 2364 3 Zeitpunkten Zeitpunkten NNP cord-015365-iqdi99pd 2364 4 bestimmt bestimmt NNP cord-015365-iqdi99pd 2364 5 , , , cord-015365-iqdi99pd 2364 6 histologische histologische NNP cord-015365-iqdi99pd 2364 7 Untersuchungen Untersuchungen NNP cord-015365-iqdi99pd 2364 8 wurde wurde NNP cord-015365-iqdi99pd 2364 9 durchgefü durchgefü NNP cord-015365-iqdi99pd 2364 10 hrt hrt NNP cord-015365-iqdi99pd 2364 11 . . . cord-015365-iqdi99pd 2365 1 Die die VB cord-015365-iqdi99pd 2365 2 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2365 3 wurden wurden VBD cord-015365-iqdi99pd 2365 4 24 24 CD cord-015365-iqdi99pd 2365 5 h h NN cord-015365-iqdi99pd 2365 6 vor vor NN cord-015365-iqdi99pd 2366 1 Ischämie Ischämie NNP cord-015365-iqdi99pd 2366 2 und und IN cord-015365-iqdi99pd 2366 3 unmittelbar unmittelbar NNP cord-015365-iqdi99pd 2366 4 nach nach NNP cord-015365-iqdi99pd 2366 5 Reperfusion Reperfusion NNP cord-015365-iqdi99pd 2366 6 oral oral JJ cord-015365-iqdi99pd 2366 7 appliziert appliziert NN cord-015365-iqdi99pd 2366 8 . . . cord-015365-iqdi99pd 2367 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2367 2 . . . cord-015365-iqdi99pd 2368 1 Zwei Zwei NNP cord-015365-iqdi99pd 2368 2 der der NN cord-015365-iqdi99pd 2368 3 getesteten getesteten NNP cord-015365-iqdi99pd 2369 1 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2370 1 führten führten NNP cord-015365-iqdi99pd 2370 2 zu zu NNP cord-015365-iqdi99pd 2371 1 einer einer NNP cord-015365-iqdi99pd 2371 2 starken starken VBD cord-015365-iqdi99pd 2371 3 Hochregulation Hochregulation NNP cord-015365-iqdi99pd 2372 1 ( ( -LRB- cord-015365-iqdi99pd 2372 2 Resveratrol resveratrol NN cord-015365-iqdi99pd 2372 3 : : : cord-015365-iqdi99pd 2372 4 11-fach 11-fach CD cord-015365-iqdi99pd 2372 5 , , , cord-015365-iqdi99pd 2372 6 Ginseng ginseng NN cord-015365-iqdi99pd 2372 7 : : : cord-015365-iqdi99pd 2372 8 17fach 17fach LS cord-015365-iqdi99pd 2372 9 ) ) -RRB- cord-015365-iqdi99pd 2372 10 der der NNP cord-015365-iqdi99pd 2372 11 HO-1 HO-1 NNP cord-015365-iqdi99pd 2372 12 Expression Expression NNP cord-015365-iqdi99pd 2372 13 . . . cord-015365-iqdi99pd 2373 1 I -PRON- PRP cord-015365-iqdi99pd 2374 1 m m LS cord-015365-iqdi99pd 2375 1 Nierenarterien Nierenarterien NNP cord-015365-iqdi99pd 2375 2 - - HYPH cord-015365-iqdi99pd 2375 3 Klemmmodell Klemmmodell NNP cord-015365-iqdi99pd 2375 4 kam kam NNP cord-015365-iqdi99pd 2376 1 es es NNP cord-015365-iqdi99pd 2376 2 nach nach NNP cord-015365-iqdi99pd 2376 3 48 48 CD cord-015365-iqdi99pd 2376 4 Stunden Stunden NNP cord-015365-iqdi99pd 2376 5 zu zu NNP cord-015365-iqdi99pd 2376 6 einem einem NNP cord-015365-iqdi99pd 2377 1 Anstieg Anstieg NNP cord-015365-iqdi99pd 2377 2 des des NNP cord-015365-iqdi99pd 2377 3 Serum Serum NNP cord-015365-iqdi99pd 2377 4 - - HYPH cord-015365-iqdi99pd 2377 5 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2377 6 von von NNP cord-015365-iqdi99pd 2377 7 0,38 0,38 CD cord-015365-iqdi99pd 2378 1 mg mg NNP cord-015365-iqdi99pd 2378 2 / / SYM cord-015365-iqdi99pd 2378 3 dl dl NNP cord-015365-iqdi99pd 2378 4 AE AE NNP cord-015365-iqdi99pd 2378 5 0,07 0,07 CD cord-015365-iqdi99pd 2379 1 auf auf NNP cord-015365-iqdi99pd 2379 2 3,06 3,06 NNP cord-015365-iqdi99pd 2379 3 mg mg NNP cord-015365-iqdi99pd 2379 4 / / SYM cord-015365-iqdi99pd 2379 5 dl dl NNP cord-015365-iqdi99pd 2379 6 AE AE NNP cord-015365-iqdi99pd 2379 7 0,86 0,86 NNP cord-015365-iqdi99pd 2379 8 in in IN cord-015365-iqdi99pd 2379 9 den den NNP cord-015365-iqdi99pd 2379 10 Kontrolltieren Kontrolltieren NNP cord-015365-iqdi99pd 2379 11 . . . cord-015365-iqdi99pd 2380 1 Die die VB cord-015365-iqdi99pd 2381 1 Applikation Applikation NNP cord-015365-iqdi99pd 2381 2 von von NNP cord-015365-iqdi99pd 2381 3 beiden beiden NNP cord-015365-iqdi99pd 2382 1 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2382 2 in in IN cord-015365-iqdi99pd 2382 3 einer einer NNP cord-015365-iqdi99pd 2382 4 Dosierung Dosierung NNP cord-015365-iqdi99pd 2382 5 von von NNP cord-015365-iqdi99pd 2383 1 10 10 CD cord-015365-iqdi99pd 2383 2 mg mg NNP cord-015365-iqdi99pd 2383 3 / / SYM cord-015365-iqdi99pd 2383 4 kg kg NNP cord-015365-iqdi99pd 2383 5 ( ( -LRB- cord-015365-iqdi99pd 2383 6 Resveratrol Resveratrol NNP cord-015365-iqdi99pd 2383 7 , , , cord-015365-iqdi99pd 2383 8 48h 48h NNPS cord-015365-iqdi99pd 2383 9 - - : cord-015365-iqdi99pd 2383 10 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2383 11 0,54 0,54 CD cord-015365-iqdi99pd 2383 12 mg mg NNP cord-015365-iqdi99pd 2383 13 / / SYM cord-015365-iqdi99pd 2383 14 dl dl NNP cord-015365-iqdi99pd 2383 15 AE AE NNP cord-015365-iqdi99pd 2383 16 0,23 0,23 CD cord-015365-iqdi99pd 2383 17 ) ) -RRB- cord-015365-iqdi99pd 2383 18 bzw bzw NNP cord-015365-iqdi99pd 2383 19 . . . cord-015365-iqdi99pd 2384 1 30 30 CD cord-015365-iqdi99pd 2384 2 mg mg NN cord-015365-iqdi99pd 2384 3 / / SYM cord-015365-iqdi99pd 2384 4 kg kg NNP cord-015365-iqdi99pd 2384 5 ( ( -LRB- cord-015365-iqdi99pd 2384 6 Ginseng Ginseng NNP cord-015365-iqdi99pd 2384 7 , , , cord-015365-iqdi99pd 2385 1 48h 48h NNP cord-015365-iqdi99pd 2385 2 - - : cord-015365-iqdi99pd 2385 3 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2385 4 0,53 0,53 CD cord-015365-iqdi99pd 2385 5 mg mg NNP cord-015365-iqdi99pd 2385 6 / / SYM cord-015365-iqdi99pd 2385 7 dl dl NNP cord-015365-iqdi99pd 2385 8 AE AE NNP cord-015365-iqdi99pd 2385 9 0,06 0,06 NNP cord-015365-iqdi99pd 2385 10 ) ) -RRB- cord-015365-iqdi99pd 2386 1 verhinderte verhinderte NNP cord-015365-iqdi99pd 2386 2 dramatisch dramatisch NNP cord-015365-iqdi99pd 2386 3 die die VBP cord-015365-iqdi99pd 2386 4 Einschränkung Einschränkung NNP cord-015365-iqdi99pd 2386 5 der der NNP cord-015365-iqdi99pd 2386 6 Nierenfunktion Nierenfunktion NNP cord-015365-iqdi99pd 2386 7 ( ( -LRB- cord-015365-iqdi99pd 2386 8 p p NN cord-015365-iqdi99pd 2386 9 < < XX cord-015365-iqdi99pd 2386 10 0,0001 0,0001 . cord-015365-iqdi99pd 2386 11 für für JJ cord-015365-iqdi99pd 2386 12 beide beide NN cord-015365-iqdi99pd 2386 13 vs. vs. FW cord-015365-iqdi99pd 2386 14 Kontrolle Kontrolle NNP cord-015365-iqdi99pd 2386 15 ) ) -RRB- cord-015365-iqdi99pd 2386 16 . . . cord-015365-iqdi99pd 2387 1 Die die VB cord-015365-iqdi99pd 2387 2 kompetitive kompetitive NNP cord-015365-iqdi99pd 2388 1 Antagonisierung Antagonisierung NNP cord-015365-iqdi99pd 2388 2 durch durch NNP cord-015365-iqdi99pd 2388 3 SnPP SnPP NNP cord-015365-iqdi99pd 2388 4 ( ( -LRB- cord-015365-iqdi99pd 2388 5 5 5 CD cord-015365-iqdi99pd 2388 6 mg mg NNP cord-015365-iqdi99pd 2388 7 / / SYM cord-015365-iqdi99pd 2388 8 kg kg NNP cord-015365-iqdi99pd 2388 9 / / SYM cord-015365-iqdi99pd 2388 10 KG KG NNP cord-015365-iqdi99pd 2388 11 ) ) -RRB- cord-015365-iqdi99pd 2388 12 konnte konnte NNP cord-015365-iqdi99pd 2388 13 diesen diesen NNP cord-015365-iqdi99pd 2388 14 positiven positiven NNP cord-015365-iqdi99pd 2388 15 Effekt Effekt NNP cord-015365-iqdi99pd 2388 16 vermindern vermindern NN cord-015365-iqdi99pd 2388 17 . . . cord-015365-iqdi99pd 2389 1 Histologische Histologische NNP cord-015365-iqdi99pd 2389 2 und und IN cord-015365-iqdi99pd 2390 1 immunhistochemische immunhistochemische NNP cord-015365-iqdi99pd 2390 2 Auswertungen Auswertungen NNP cord-015365-iqdi99pd 2390 3 unterstützen unterstützen NNP cord-015365-iqdi99pd 2390 4 die die VB cord-015365-iqdi99pd 2390 5 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2390 6 . . . cord-015365-iqdi99pd 2391 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2391 2 . . . cord-015365-iqdi99pd 2392 1 Die die VB cord-015365-iqdi99pd 2392 2 Anwendung Anwendung NNP cord-015365-iqdi99pd 2392 3 von von NNP cord-015365-iqdi99pd 2393 1 fü fü IN cord-015365-iqdi99pd 2394 1 r r LS cord-015365-iqdi99pd 2394 2 Menschen Menschen NNP cord-015365-iqdi99pd 2394 3 ungefährlichen ungefährlichen NNP cord-015365-iqdi99pd 2395 1 Nutrazeutika Nutrazeutika NNP cord-015365-iqdi99pd 2396 1 stellt stellt NNP cord-015365-iqdi99pd 2396 2 eine eine NNP cord-015365-iqdi99pd 2396 3 ausgezeichnete ausgezeichnete NN cord-015365-iqdi99pd 2396 4 Möglichkeit Möglichkeit NNP cord-015365-iqdi99pd 2396 5 dar dar NNP cord-015365-iqdi99pd 2396 6 , , , cord-015365-iqdi99pd 2396 7 die die VB cord-015365-iqdi99pd 2397 1 HO-1 HO-1 NNP cord-015365-iqdi99pd 2397 2 zu zu NNP cord-015365-iqdi99pd 2397 3 induzieren induzieren NNP cord-015365-iqdi99pd 2398 1 und und IN cord-015365-iqdi99pd 2398 2 den den NNP cord-015365-iqdi99pd 2398 3 IRS IRS NNP cord-015365-iqdi99pd 2398 4 zu zu NNP cord-015365-iqdi99pd 2398 5 minimieren minimieren NNP cord-015365-iqdi99pd 2398 6 . . . cord-015365-iqdi99pd 2399 1 The the DT cord-015365-iqdi99pd 2399 2 novel novel JJ cord-015365-iqdi99pd 2399 3 compound compound NN cord-015365-iqdi99pd 2399 4 5 5 CD cord-015365-iqdi99pd 2399 5 0 0 CD cord-015365-iqdi99pd 2400 1 -methoxy -methoxy : cord-015365-iqdi99pd 2400 2 leoligin leoligin NNP cord-015365-iqdi99pd 2400 3 increases increase VBZ cord-015365-iqdi99pd 2400 4 the the DT cord-015365-iqdi99pd 2400 5 ejection ejection NN cord-015365-iqdi99pd 2400 6 fraction fraction NN cord-015365-iqdi99pd 2400 7 of of IN cord-015365-iqdi99pd 2400 8 infarcted infarcted JJ cord-015365-iqdi99pd 2400 9 rat rat NN cord-015365-iqdi99pd 2400 10 hearts heart NNS cord-015365-iqdi99pd 2400 11 by by IN cord-015365-iqdi99pd 2400 12 promoting promote VBG cord-015365-iqdi99pd 2400 13 CYP26B1dependent CYP26B1dependent . cord-015365-iqdi99pd 2400 14 angiogenesis angiogenesis NN cord-015365-iqdi99pd 2400 15 Background background NN cord-015365-iqdi99pd 2400 16 . . . cord-015365-iqdi99pd 2401 1 In in IN cord-015365-iqdi99pd 2401 2 times time NNS cord-015365-iqdi99pd 2401 3 of of IN cord-015365-iqdi99pd 2401 4 organ organ NN cord-015365-iqdi99pd 2401 5 shortage shortage NN cord-015365-iqdi99pd 2401 6 strategies strategy NNS cord-015365-iqdi99pd 2401 7 to to IN cord-015365-iqdi99pd 2401 8 recovery recovery NN cord-015365-iqdi99pd 2401 9 damaged damage VBN cord-015365-iqdi99pd 2401 10 organs organ NNS cord-015365-iqdi99pd 2401 11 seem seem VBP cord-015365-iqdi99pd 2401 12 to to TO cord-015365-iqdi99pd 2401 13 be be VB cord-015365-iqdi99pd 2401 14 valuable valuable JJ cord-015365-iqdi99pd 2401 15 options option NNS cord-015365-iqdi99pd 2401 16 to to TO cord-015365-iqdi99pd 2401 17 face face VB cord-015365-iqdi99pd 2401 18 this this DT cord-015365-iqdi99pd 2401 19 problem problem NN cord-015365-iqdi99pd 2401 20 . . . cord-015365-iqdi99pd 2402 1 Cellular cellular JJ cord-015365-iqdi99pd 2402 2 based base VBN cord-015365-iqdi99pd 2402 3 strategies strategy NNS cord-015365-iqdi99pd 2402 4 to to TO cord-015365-iqdi99pd 2402 5 recover recover VB cord-015365-iqdi99pd 2402 6 ischemic ischemic JJ cord-015365-iqdi99pd 2402 7 myocardium myocardium NN cord-015365-iqdi99pd 2402 8 have have VBP cord-015365-iqdi99pd 2402 9 shown show VBN cord-015365-iqdi99pd 2402 10 promising promise VBG cord-015365-iqdi99pd 2402 11 experimental experimental JJ cord-015365-iqdi99pd 2402 12 results result NNS cord-015365-iqdi99pd 2402 13 but but CC cord-015365-iqdi99pd 2402 14 the the DT cord-015365-iqdi99pd 2402 15 clinical clinical JJ cord-015365-iqdi99pd 2402 16 evidence evidence NN cord-015365-iqdi99pd 2402 17 is be VBZ cord-015365-iqdi99pd 2402 18 scarce scarce JJ cord-015365-iqdi99pd 2402 19 . . . cord-015365-iqdi99pd 2403 1 Especially especially RB cord-015365-iqdi99pd 2403 2 the the DT cord-015365-iqdi99pd 2403 3 lack lack NN cord-015365-iqdi99pd 2403 4 of of IN cord-015365-iqdi99pd 2403 5 angiogenesis angiogenesis NN cord-015365-iqdi99pd 2403 6 in in IN cord-015365-iqdi99pd 2403 7 cardiac cardiac JJ cord-015365-iqdi99pd 2403 8 peri peri NN cord-015365-iqdi99pd 2403 9 - - HYPH cord-015365-iqdi99pd 2403 10 infarction infarction NN cord-015365-iqdi99pd 2403 11 and and CC cord-015365-iqdi99pd 2403 12 infarction infarction NN cord-015365-iqdi99pd 2403 13 areas area NNS cord-015365-iqdi99pd 2403 14 is be VBZ cord-015365-iqdi99pd 2403 15 one one CD cord-015365-iqdi99pd 2403 16 of of IN cord-015365-iqdi99pd 2403 17 the the DT cord-015365-iqdi99pd 2403 18 most most RBS cord-015365-iqdi99pd 2403 19 important important JJ cord-015365-iqdi99pd 2403 20 problems problem NNS cord-015365-iqdi99pd 2403 21 in in IN cord-015365-iqdi99pd 2403 22 functional functional JJ cord-015365-iqdi99pd 2403 23 cardiac cardiac JJ cord-015365-iqdi99pd 2403 24 recovery recovery NN cord-015365-iqdi99pd 2403 25 after after IN cord-015365-iqdi99pd 2403 26 myocardial myocardial JJ cord-015365-iqdi99pd 2403 27 infarction infarction NN cord-015365-iqdi99pd 2403 28 ( ( -LRB- cord-015365-iqdi99pd 2403 29 MI MI NNP cord-015365-iqdi99pd 2403 30 ) ) -RRB- cord-015365-iqdi99pd 2403 31 . . . cord-015365-iqdi99pd 2404 1 While while IN cord-015365-iqdi99pd 2404 2 searching search VBG cord-015365-iqdi99pd 2404 3 for for IN cord-015365-iqdi99pd 2404 4 possible possible JJ cord-015365-iqdi99pd 2404 5 pharmacological pharmacological JJ cord-015365-iqdi99pd 2404 6 strategies strategy NNS cord-015365-iqdi99pd 2404 7 to to TO cord-015365-iqdi99pd 2404 8 stimulate stimulate VB cord-015365-iqdi99pd 2404 9 angiogenesis angiogenesis NN cord-015365-iqdi99pd 2404 10 after after IN cord-015365-iqdi99pd 2404 11 MI MI NNP cord-015365-iqdi99pd 2404 12 we -PRON- PRP cord-015365-iqdi99pd 2404 13 conducted conduct VBD cord-015365-iqdi99pd 2404 14 a a DT cord-015365-iqdi99pd 2404 15 screen screen NN cord-015365-iqdi99pd 2404 16 for for IN cord-015365-iqdi99pd 2404 17 plant plant NN cord-015365-iqdi99pd 2404 18 compounds compound NNS cord-015365-iqdi99pd 2404 19 with with IN cord-015365-iqdi99pd 2404 20 pro pro JJ cord-015365-iqdi99pd 2404 21 - - JJ cord-015365-iqdi99pd 2404 22 neoangiogenetic neoangiogenetic JJ cord-015365-iqdi99pd 2404 23 properties property NNS cord-015365-iqdi99pd 2404 24 . . . cord-015365-iqdi99pd 2405 1 Methods method NNS cord-015365-iqdi99pd 2405 2 and and CC cord-015365-iqdi99pd 2405 3 Results result NNS cord-015365-iqdi99pd 2405 4 . . . cord-015365-iqdi99pd 2406 1 5 5 LS cord-015365-iqdi99pd 2406 2 0 0 CD cord-015365-iqdi99pd 2407 1 -methoxy -methoxy NNP cord-015365-iqdi99pd 2407 2 leoligin leoligin NNP cord-015365-iqdi99pd 2407 3 , , , cord-015365-iqdi99pd 2407 4 a a DT cord-015365-iqdi99pd 2407 5 compound compound NN cord-015365-iqdi99pd 2407 6 isolated isolate VBN cord-015365-iqdi99pd 2407 7 from from IN cord-015365-iqdi99pd 2407 8 the the DT cord-015365-iqdi99pd 2407 9 roots root NNS cord-015365-iqdi99pd 2407 10 of of IN cord-015365-iqdi99pd 2407 11 Leontopodium Leontopodium NNP cord-015365-iqdi99pd 2407 12 alpinum alpinum NN cord-015365-iqdi99pd 2407 13 ( ( -LRB- cord-015365-iqdi99pd 2407 14 Edelweiss Edelweiss NNP cord-015365-iqdi99pd 2407 15 ) ) -RRB- cord-015365-iqdi99pd 2407 16 potently potently RB cord-015365-iqdi99pd 2407 17 stimulated stimulate VBD cord-015365-iqdi99pd 2407 18 endothelial endothelial JJ cord-015365-iqdi99pd 2407 19 cell cell NN cord-015365-iqdi99pd 2407 20 migration migration NN cord-015365-iqdi99pd 2407 21 , , , cord-015365-iqdi99pd 2407 22 tube tube NN cord-015365-iqdi99pd 2407 23 forma forma NN cord-015365-iqdi99pd 2407 24 - - HYPH cord-015365-iqdi99pd 2407 25 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2407 26 . . . cord-015365-iqdi99pd 2408 1 Ungeplante Ungeplante NNP cord-015365-iqdi99pd 2408 2 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2408 3 dienen dienen NNP cord-015365-iqdi99pd 2408 4 als als NNP cord-015365-iqdi99pd 2408 5 Indikator Indikator NNP cord-015365-iqdi99pd 2408 6 der der NNP cord-015365-iqdi99pd 2408 7 Qualitätskontrolle Qualitätskontrolle NNP cord-015365-iqdi99pd 2408 8 in in IN cord-015365-iqdi99pd 2408 9 der der NNP cord-015365-iqdi99pd 2408 10 Chirurgie Chirurgie NNP cord-015365-iqdi99pd 2408 11 . . . cord-015365-iqdi99pd 2409 1 Daten Daten NNP cord-015365-iqdi99pd 2409 2 für für FW cord-015365-iqdi99pd 2409 3 die die VBP cord-015365-iqdi99pd 2409 4 Nierentransplantation Nierentransplantation NNP cord-015365-iqdi99pd 2409 5 liegen liegen NNP cord-015365-iqdi99pd 2409 6 noch noch FW cord-015365-iqdi99pd 2409 7 nicht nicht FW cord-015365-iqdi99pd 2409 8 vor vor NNP cord-015365-iqdi99pd 2409 9 . . . cord-015365-iqdi99pd 2410 1 Methodik Methodik NNP cord-015365-iqdi99pd 2410 2 . . . cord-015365-iqdi99pd 2411 1 Retrospektive Retrospektive NNP cord-015365-iqdi99pd 2411 2 Analyse Analyse NNP cord-015365-iqdi99pd 2411 3 von von NNP cord-015365-iqdi99pd 2411 4 320 320 CD cord-015365-iqdi99pd 2411 5 Nierentransplantationen Nierentransplantationen NNP cord-015365-iqdi99pd 2411 6 zwischen zwischen NNP cord-015365-iqdi99pd 2411 7 9/2002 9/2002 CD cord-015365-iqdi99pd 2412 1 und und NNP cord-015365-iqdi99pd 2413 1 12/2010 12/2010 CD cord-015365-iqdi99pd 2413 2 . . . cord-015365-iqdi99pd 2414 1 Die die VB cord-015365-iqdi99pd 2415 1 Anzahl Anzahl NNP cord-015365-iqdi99pd 2415 2 der der NNP cord-015365-iqdi99pd 2415 3 ungeplanten ungeplanten NNP cord-015365-iqdi99pd 2415 4 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2415 5 und und IN cord-015365-iqdi99pd 2415 6 Ursache Ursache NNP cord-015365-iqdi99pd 2415 7 , , , cord-015365-iqdi99pd 2415 8 Mortalität Mortalität NNP cord-015365-iqdi99pd 2415 9 , , , cord-015365-iqdi99pd 2416 1 Kreatininspiegel Kreatininspiegel NNP cord-015365-iqdi99pd 2416 2 1 1 CD cord-015365-iqdi99pd 2416 3 Monat Monat NNP cord-015365-iqdi99pd 2416 4 und und XX cord-015365-iqdi99pd 2417 1 1 1 LS cord-015365-iqdi99pd 2417 2 Jahr Jahr NNP cord-015365-iqdi99pd 2417 3 post post NN cord-015365-iqdi99pd 2417 4 TX TX NNP cord-015365-iqdi99pd 2418 1 und und NNP cord-015365-iqdi99pd 2418 2 die die VBP cord-015365-iqdi99pd 2418 3 Art art NN cord-015365-iqdi99pd 2418 4 der der NN cord-015365-iqdi99pd 2418 5 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 2418 6 in in IN cord-015365-iqdi99pd 2418 7 Bezug Bezug NNP cord-015365-iqdi99pd 2418 8 zum zum NNP cord-015365-iqdi99pd 2418 9 Organverlust Organverlust NNP cord-015365-iqdi99pd 2418 10 wurden wurden VBD cord-015365-iqdi99pd 2418 11 als als NNP cord-015365-iqdi99pd 2418 12 mögliche mögliche NN cord-015365-iqdi99pd 2418 13 Risikofaktoren Risikofaktoren NNP cord-015365-iqdi99pd 2418 14 evaluiert evaluiert NN cord-015365-iqdi99pd 2418 15 . . . cord-015365-iqdi99pd 2419 1 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2419 2 . . . cord-015365-iqdi99pd 2420 1 In in IN cord-015365-iqdi99pd 2420 2 der der NN cord-015365-iqdi99pd 2420 3 Analyse Analyse NNP cord-015365-iqdi99pd 2420 4 unseres unseres NNP cord-015365-iqdi99pd 2420 5 Patientenkollektives Patientenkollektives NNP cord-015365-iqdi99pd 2420 6 ( ( -LRB- cord-015365-iqdi99pd 2420 7 320 320 CD cord-015365-iqdi99pd 2420 8 Nierentransplantationen Nierentransplantationen NNP cord-015365-iqdi99pd 2420 9 über über NNP cord-015365-iqdi99pd 2420 10 100 100 CD cord-015365-iqdi99pd 2420 11 Monate Monate NNP cord-015365-iqdi99pd 2420 12 ) ) -RRB- cord-015365-iqdi99pd 2420 13 zeigt zeigt NNP cord-015365-iqdi99pd 2420 14 sich sich NNP cord-015365-iqdi99pd 2420 15 eine eine NNP cord-015365-iqdi99pd 2420 16 14 14 CD cord-015365-iqdi99pd 2420 17 % % NN cord-015365-iqdi99pd 2420 18 ige ige NNP cord-015365-iqdi99pd 2420 19 Reoperationsrate Reoperationsrate NNP cord-015365-iqdi99pd 2420 20 , , , cord-015365-iqdi99pd 2420 21 dies die VBZ cord-015365-iqdi99pd 2420 22 entspricht entspricht NNP cord-015365-iqdi99pd 2421 1 46 46 CD cord-015365-iqdi99pd 2421 2 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2421 3 , , , cord-015365-iqdi99pd 2421 4 wobei wobei JJ cord-015365-iqdi99pd 2421 5 bei bei NNP cord-015365-iqdi99pd 2421 6 16 16 CD cord-015365-iqdi99pd 2421 7 % % NN cord-015365-iqdi99pd 2421 8 der der NNP cord-015365-iqdi99pd 2421 9 Reoperierten Reoperierten NNP cord-015365-iqdi99pd 2421 10 mehr mehr JJ cord-015365-iqdi99pd 2421 11 als als NNP cord-015365-iqdi99pd 2421 12 eine eine NNP cord-015365-iqdi99pd 2421 13 Reoperation Reoperation NNP cord-015365-iqdi99pd 2421 14 notwendig notwendig JJ cord-015365-iqdi99pd 2421 15 war war NN cord-015365-iqdi99pd 2421 16 . . . cord-015365-iqdi99pd 2422 1 Ursächlich Ursächlich NNP cord-015365-iqdi99pd 2422 2 dafür dafür NNP cord-015365-iqdi99pd 2422 3 waren waren NNP cord-015365-iqdi99pd 2423 1 vordergründig vordergründig NNP cord-015365-iqdi99pd 2423 2 Gefäßkomplikationen Gefäßkomplikationen NNP cord-015365-iqdi99pd 2423 3 ( ( -LRB- cord-015365-iqdi99pd 2423 4 30 30 CD cord-015365-iqdi99pd 2423 5 % % NN cord-015365-iqdi99pd 2423 6 ) ) -RRB- cord-015365-iqdi99pd 2424 1 gefolgt gefolgt NNP cord-015365-iqdi99pd 2424 2 von von NNP cord-015365-iqdi99pd 2424 3 Hämatomausräumungen Hämatomausräumungen NNP cord-015365-iqdi99pd 2424 4 und und IN cord-015365-iqdi99pd 2424 5 Wundinfektionen Wundinfektionen NNP cord-015365-iqdi99pd 2424 6 , , , cord-015365-iqdi99pd 2424 7 welche welche NNP cord-015365-iqdi99pd 2424 8 einer einer NNP cord-015365-iqdi99pd 2424 9 operativen operativen NNP cord-015365-iqdi99pd 2424 10 Sanierung Sanierung NNP cord-015365-iqdi99pd 2424 11 bedurften bedurften NNP cord-015365-iqdi99pd 2424 12 ( ( -LRB- cord-015365-iqdi99pd 2424 13 28 28 CD cord-015365-iqdi99pd 2424 14 % % NN cord-015365-iqdi99pd 2424 15 ) ) -RRB- cord-015365-iqdi99pd 2424 16 . . . cord-015365-iqdi99pd 2425 1 Seltener Seltener NNP cord-015365-iqdi99pd 2425 2 kam kam NNP cord-015365-iqdi99pd 2425 3 es es XX cord-015365-iqdi99pd 2425 4 zu zu NNP cord-015365-iqdi99pd 2425 5 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2425 6 aufgrund aufgrund IN cord-015365-iqdi99pd 2425 7 urologischer urologischer JJ cord-015365-iqdi99pd 2425 8 Ursachen Ursachen NNP cord-015365-iqdi99pd 2425 9 ( ( -LRB- cord-015365-iqdi99pd 2425 10 20 20 CD cord-015365-iqdi99pd 2425 11 % % NN cord-015365-iqdi99pd 2425 12 ) ) -RRB- cord-015365-iqdi99pd 2425 13 , , . cord-015365-iqdi99pd 2426 1 Lymphozelen Lymphozelen NNP cord-015365-iqdi99pd 2426 2 und und IN cord-015365-iqdi99pd 2426 3 abdomineller abdomineller NNP cord-015365-iqdi99pd 2426 4 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 2426 5 ( ( -LRB- cord-015365-iqdi99pd 2426 6 je je NNP cord-015365-iqdi99pd 2426 7 6,5 6,5 CD cord-015365-iqdi99pd 2426 8 % % NN cord-015365-iqdi99pd 2426 9 ) ) -RRB- cord-015365-iqdi99pd 2426 10 . . . cord-015365-iqdi99pd 2427 1 Von Von NNP cord-015365-iqdi99pd 2427 2 insgesamt insgesamt NNP cord-015365-iqdi99pd 2428 1 40 40 CD cord-015365-iqdi99pd 2428 2 Organverlusten Organverlusten NNP cord-015365-iqdi99pd 2428 3 waren waren XX cord-015365-iqdi99pd 2429 1 17 17 CD cord-015365-iqdi99pd 2429 2 bei bei NNP cord-015365-iqdi99pd 2429 3 reoperierten reoperierten NNP cord-015365-iqdi99pd 2430 1 Patienten Patienten NNP cord-015365-iqdi99pd 2430 2 ( ( -LRB- cord-015365-iqdi99pd 2430 3 das das NNP cord-015365-iqdi99pd 2430 4 entspricht entspricht NNP cord-015365-iqdi99pd 2431 1 43 43 CD cord-015365-iqdi99pd 2431 2 % % NN cord-015365-iqdi99pd 2431 3 der der NN cord-015365-iqdi99pd 2431 4 reoperierten reoperierten FW cord-015365-iqdi99pd 2431 5 Patienten Patienten NNP cord-015365-iqdi99pd 2431 6 ) ) -RRB- cord-015365-iqdi99pd 2432 1 und und IN cord-015365-iqdi99pd 2432 2 23 23 CD cord-015365-iqdi99pd 2432 3 ( ( -LRB- cord-015365-iqdi99pd 2432 4 9 9 CD cord-015365-iqdi99pd 2432 5 % % NN cord-015365-iqdi99pd 2432 6 ) ) -RRB- cord-015365-iqdi99pd 2433 1 bei bei NNP cord-015365-iqdi99pd 2433 2 nicht nicht NNP cord-015365-iqdi99pd 2433 3 reoperierten reoperierten NNP cord-015365-iqdi99pd 2433 4 Patienten Patienten NNP cord-015365-iqdi99pd 2433 5 zu zu NNP cord-015365-iqdi99pd 2433 6 verzeichnen verzeichnen NNP cord-015365-iqdi99pd 2433 7 ( ( -LRB- cord-015365-iqdi99pd 2433 8 p p NN cord-015365-iqdi99pd 2433 9 < < XX cord-015365-iqdi99pd 2433 10 0,001 0,001 CD cord-015365-iqdi99pd 2433 11 ) ) -RRB- cord-015365-iqdi99pd 2433 12 . . . cord-015365-iqdi99pd 2434 1 In in IN cord-015365-iqdi99pd 2434 2 der der NNP cord-015365-iqdi99pd 2434 3 Subanalyse Subanalyse NNP cord-015365-iqdi99pd 2434 4 der der NNP cord-015365-iqdi99pd 2434 5 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 2434 6 , , , cord-015365-iqdi99pd 2434 7 welche welche NNP cord-015365-iqdi99pd 2434 8 zu zu NNP cord-015365-iqdi99pd 2434 9 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2434 10 führten führten NNP cord-015365-iqdi99pd 2434 11 , , , cord-015365-iqdi99pd 2434 12 sind sind NNP cord-015365-iqdi99pd 2434 13 Gefäßkomplikationen Gefäßkomplikationen NNP cord-015365-iqdi99pd 2434 14 die die VBP cord-015365-iqdi99pd 2434 15 häufigste häufigste NN cord-015365-iqdi99pd 2434 16 Ursache Ursache NNP cord-015365-iqdi99pd 2434 17 für für IN cord-015365-iqdi99pd 2434 18 vorzeitigen vorzeitigen NNP cord-015365-iqdi99pd 2434 19 Organverlust Organverlust NNP cord-015365-iqdi99pd 2434 20 ( ( -LRB- cord-015365-iqdi99pd 2434 21 64 64 CD cord-015365-iqdi99pd 2434 22 % % NN cord-015365-iqdi99pd 2435 1 , , , cord-015365-iqdi99pd 2435 2 das das NNP cord-015365-iqdi99pd 2435 3 entspricht entspricht NNP cord-015365-iqdi99pd 2435 4 9 9 CD cord-015365-iqdi99pd 2435 5 von von NNP cord-015365-iqdi99pd 2435 6 14 14 CD cord-015365-iqdi99pd 2435 7 Reoperationen Reoperationen NNP cord-015365-iqdi99pd 2435 8 vs. vs. IN cord-015365-iqdi99pd 2435 9 33 33 CD cord-015365-iqdi99pd 2435 10 % % NN cord-015365-iqdi99pd 2435 11 bei bei NNP cord-015365-iqdi99pd 2435 12 Lymphozelen Lymphozelen NNP cord-015365-iqdi99pd 2435 13 , , , cord-015365-iqdi99pd 2435 14 33 33 CD cord-015365-iqdi99pd 2435 15 % % NN cord-015365-iqdi99pd 2435 16 bei bei NNP cord-015365-iqdi99pd 2435 17 abdominellen abdominellen NNP cord-015365-iqdi99pd 2435 18 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 2435 19 , , , cord-015365-iqdi99pd 2435 20 31 31 CD cord-015365-iqdi99pd 2435 21 % % NN cord-015365-iqdi99pd 2435 22 bei bei NNP cord-015365-iqdi99pd 2435 23 Weichteilproblemen Weichteilproblemen NNP cord-015365-iqdi99pd 2435 24 und und IN cord-015365-iqdi99pd 2435 25 11 11 CD cord-015365-iqdi99pd 2435 26 % % NN cord-015365-iqdi99pd 2435 27 bei bei NNP cord-015365-iqdi99pd 2435 28 urologischen urologischen NNP cord-015365-iqdi99pd 2435 29 Komplikationen Komplikationen NNP cord-015365-iqdi99pd 2435 30 ) ) -RRB- cord-015365-iqdi99pd 2435 31 . . . cord-015365-iqdi99pd 2436 1 In in IN cord-015365-iqdi99pd 2436 2 Bezug Bezug NNP cord-015365-iqdi99pd 2436 3 zur zur NNP cord-015365-iqdi99pd 2436 4 Immunsuppression Immunsuppression NNP cord-015365-iqdi99pd 2436 5 konnten konnten NNP cord-015365-iqdi99pd 2436 6 keine keine NNP cord-015365-iqdi99pd 2436 7 statistisch statistisch NN cord-015365-iqdi99pd 2436 8 signifikanten signifikanten NNP cord-015365-iqdi99pd 2436 9 Unterschiede Unterschiede NNP cord-015365-iqdi99pd 2436 10 erhoben erhoben NNP cord-015365-iqdi99pd 2436 11 werden werden NNP cord-015365-iqdi99pd 2436 12 . . . cord-015365-iqdi99pd 2437 1 Ein Ein NNP cord-015365-iqdi99pd 2437 2 erhöhtes erhöhte NNS cord-015365-iqdi99pd 2438 1 Serum serum NN cord-015365-iqdi99pd 2438 2 - - HYPH cord-015365-iqdi99pd 2438 3 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2438 4 nach nach NN cord-015365-iqdi99pd 2438 5 1 1 CD cord-015365-iqdi99pd 2438 6 Monat Monat NNP cord-015365-iqdi99pd 2438 7 ( ( -LRB- cord-015365-iqdi99pd 2438 8 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2438 9 > > XX cord-015365-iqdi99pd 2439 1 2 2 LS cord-015365-iqdi99pd 2439 2 ) ) -RRB- cord-015365-iqdi99pd 2440 1 fand fand UH cord-015365-iqdi99pd 2440 2 sich sich NNP cord-015365-iqdi99pd 2440 3 bei bei NNP cord-015365-iqdi99pd 2440 4 42 42 CD cord-015365-iqdi99pd 2440 5 % % NN cord-015365-iqdi99pd 2440 6 der der NN cord-015365-iqdi99pd 2440 7 reoperierten reoperierten NNP cord-015365-iqdi99pd 2440 8 vs. vs. FW cord-015365-iqdi99pd 2440 9 16,5 16,5 CD cord-015365-iqdi99pd 2440 10 % % NN cord-015365-iqdi99pd 2440 11 der der NN cord-015365-iqdi99pd 2440 12 nicht nicht NNP cord-015365-iqdi99pd 2440 13 reoperierten reoperierten NNP cord-015365-iqdi99pd 2441 1 Patienten Patienten NNP cord-015365-iqdi99pd 2441 2 ( ( -LRB- cord-015365-iqdi99pd 2441 3 p p NN cord-015365-iqdi99pd 2441 4 < < XX cord-015365-iqdi99pd 2441 5 0,001 0,001 CD cord-015365-iqdi99pd 2441 6 ) ) -RRB- cord-015365-iqdi99pd 2441 7 . . . cord-015365-iqdi99pd 2442 1 Nach Nach NNP cord-015365-iqdi99pd 2442 2 einem einem NNP cord-015365-iqdi99pd 2442 3 Jahr Jahr NNP cord-015365-iqdi99pd 2442 4 war war NN cord-015365-iqdi99pd 2442 5 das das NNP cord-015365-iqdi99pd 2442 6 Kreatinin Kreatinin NNP cord-015365-iqdi99pd 2442 7 bei bei NNP cord-015365-iqdi99pd 2442 8 37 37 CD cord-015365-iqdi99pd 2442 9 % % NN cord-015365-iqdi99pd 2442 10 der der NN cord-015365-iqdi99pd 2442 11 reoperierten reoperierten NNP cord-015365-iqdi99pd 2443 1 Patienten Patienten NNP cord-015365-iqdi99pd 2443 2 > > XX cord-015365-iqdi99pd 2444 1 2 2 LS cord-015365-iqdi99pd 2444 2 , , , cord-015365-iqdi99pd 2444 3 hingegen hingegen NNP cord-015365-iqdi99pd 2444 4 nur nur NNP cord-015365-iqdi99pd 2444 5 bei bei NNP cord-015365-iqdi99pd 2444 6 16,5 16,5 CD cord-015365-iqdi99pd 2444 7 % % NN cord-015365-iqdi99pd 2445 1 der der NNP cord-015365-iqdi99pd 2445 2 nicht nicht NNP cord-015365-iqdi99pd 2445 3 reoperierten reoperierten NNP cord-015365-iqdi99pd 2445 4 Patienten Patienten NNP cord-015365-iqdi99pd 2445 5 ( ( -LRB- cord-015365-iqdi99pd 2445 6 p p NN cord-015365-iqdi99pd 2445 7 ¼ ¼ CD cord-015365-iqdi99pd 2445 8 0,005 0,005 CD cord-015365-iqdi99pd 2445 9 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2445 10 . . . cord-015365-iqdi99pd 2446 1 Varizen varizen NN cord-015365-iqdi99pd 2446 2 wurden wurden VBD cord-015365-iqdi99pd 2446 3 mittels mittels NNP cord-015365-iqdi99pd 2446 4 Ö Ö NNP cord-015365-iqdi99pd 2446 5 sophago sophago NNP cord-015365-iqdi99pd 2446 6 - - HYPH cord-015365-iqdi99pd 2446 7 Gastroskopie Gastroskopie NNP cord-015365-iqdi99pd 2446 8 in in IN cord-015365-iqdi99pd 2446 9 287 287 CD cord-015365-iqdi99pd 2446 10 ( ( -LRB- cord-015365-iqdi99pd 2446 11 72,5 72,5 CD cord-015365-iqdi99pd 2446 12 % % NN cord-015365-iqdi99pd 2446 13 ) ) -RRB- cord-015365-iqdi99pd 2447 1 von von NNP cord-015365-iqdi99pd 2447 2 396 396 CD cord-015365-iqdi99pd 2447 3 untersuchten untersuchten NNP cord-015365-iqdi99pd 2447 4 Patienten Patienten NNP cord-015365-iqdi99pd 2447 5 dokumentiert dokumentiert NN cord-015365-iqdi99pd 2447 6 , , , cord-015365-iqdi99pd 2447 7 wobei wobei FW cord-015365-iqdi99pd 2447 8 nur nur NNP cord-015365-iqdi99pd 2447 9 in in IN cord-015365-iqdi99pd 2447 10 einem einem NNP cord-015365-iqdi99pd 2447 11 Fall Fall NNP cord-015365-iqdi99pd 2447 12 schwere schwere NN cord-015365-iqdi99pd 2447 13 Blutungen Blutungen NNP cord-015365-iqdi99pd 2447 14 aus aus NNP cord-015365-iqdi99pd 2447 15 Case Case NNP cord-015365-iqdi99pd 2447 16 Report Report NNP cord-015365-iqdi99pd 2447 17 . . . cord-015365-iqdi99pd 2448 1 11 11 CD cord-015365-iqdi99pd 2448 2 years year NNS cord-015365-iqdi99pd 2448 3 after after IN cord-015365-iqdi99pd 2448 4 bilateral bilateral JJ cord-015365-iqdi99pd 2448 5 hand hand NN cord-015365-iqdi99pd 2448 6 transplantation transplantation NN cord-015365-iqdi99pd 2448 7 a a DT cord-015365-iqdi99pd 2448 8 patient patient NN cord-015365-iqdi99pd 2448 9 developed develop VBD cord-015365-iqdi99pd 2448 10 a a DT cord-015365-iqdi99pd 2448 11 bullous bullous JJ cord-015365-iqdi99pd 2448 12 pemphigoid pemphigoid NN cord-015365-iqdi99pd 2448 13 ( ( -LRB- cord-015365-iqdi99pd 2448 14 BP BP NNP cord-015365-iqdi99pd 2448 15 ) ) -RRB- cord-015365-iqdi99pd 2448 16 , , , cord-015365-iqdi99pd 2448 17 which which WDT cord-015365-iqdi99pd 2448 18 is be VBZ cord-015365-iqdi99pd 2448 19 an an DT cord-015365-iqdi99pd 2448 20 autoimmune autoimmune JJ cord-015365-iqdi99pd 2448 21 blistering blistering JJ cord-015365-iqdi99pd 2448 22 skin skin NN cord-015365-iqdi99pd 2448 23 disease disease NN cord-015365-iqdi99pd 2448 24 , , , cord-015365-iqdi99pd 2448 25 characterized characterize VBN cord-015365-iqdi99pd 2448 26 by by IN cord-015365-iqdi99pd 2448 27 autoantibodies autoantibody NNS cord-015365-iqdi99pd 2448 28 targeting target VBG cord-015365-iqdi99pd 2448 29 the the DT cord-015365-iqdi99pd 2448 30 type type NN cord-015365-iqdi99pd 2448 31 XVII XVII NNP cord-015365-iqdi99pd 2448 32 collagen collagen NN cord-015365-iqdi99pd 2448 33 component component NN cord-015365-iqdi99pd 2448 34 of of IN cord-015365-iqdi99pd 2448 35 hemidesmosomes hemidesmosome NNS cord-015365-iqdi99pd 2448 36 in in IN cord-015365-iqdi99pd 2448 37 the the DT cord-015365-iqdi99pd 2448 38 skin skin NN cord-015365-iqdi99pd 2448 39 basement basement NN cord-015365-iqdi99pd 2448 40 membrane membrane NN cord-015365-iqdi99pd 2448 41 zone zone NN cord-015365-iqdi99pd 2448 42 . . . cord-015365-iqdi99pd 2449 1 This this DT cord-015365-iqdi99pd 2449 2 is be VBZ cord-015365-iqdi99pd 2449 3 the the DT cord-015365-iqdi99pd 2449 4 first first JJ cord-015365-iqdi99pd 2449 5 report report NN cord-015365-iqdi99pd 2449 6 on on IN cord-015365-iqdi99pd 2449 7 an an DT cord-015365-iqdi99pd 2449 8 autoimmune autoimmune JJ cord-015365-iqdi99pd 2449 9 complication complication NN cord-015365-iqdi99pd 2449 10 in in IN cord-015365-iqdi99pd 2449 11 a a DT cord-015365-iqdi99pd 2449 12 patient patient NN cord-015365-iqdi99pd 2449 13 after after IN cord-015365-iqdi99pd 2449 14 vascularized vascularized JJ cord-015365-iqdi99pd 2449 15 composite composite JJ cord-015365-iqdi99pd 2449 16 allotransplantation allotransplantation NN cord-015365-iqdi99pd 2449 17 ( ( -LRB- cord-015365-iqdi99pd 2449 18 VCA VCA NNP cord-015365-iqdi99pd 2449 19 ) ) -RRB- cord-015365-iqdi99pd 2449 20 . . . cord-015365-iqdi99pd 2450 1 The the DT cord-015365-iqdi99pd 2450 2 patient patient NN cord-015365-iqdi99pd 2450 3 showed show VBD cord-015365-iqdi99pd 2450 4 a a DT cord-015365-iqdi99pd 2450 5 quite quite JJ cord-015365-iqdi99pd 2450 6 Background background NN cord-015365-iqdi99pd 2450 7 . . . cord-015365-iqdi99pd 2451 1 The the DT cord-015365-iqdi99pd 2451 2 Mounier Mounier NNP cord-015365-iqdi99pd 2451 3 - - HYPH cord-015365-iqdi99pd 2451 4 Kuhn Kuhn NNP cord-015365-iqdi99pd 2451 5 syndrome syndrome NN cord-015365-iqdi99pd 2451 6 ( ( -LRB- cord-015365-iqdi99pd 2451 7 MKS MKS NNP cord-015365-iqdi99pd 2451 8 ) ) -RRB- cord-015365-iqdi99pd 2451 9 is be VBZ cord-015365-iqdi99pd 2451 10 a a DT cord-015365-iqdi99pd 2451 11 rare rare JJ cord-015365-iqdi99pd 2451 12 disease disease NN cord-015365-iqdi99pd 2451 13 characterized characterize VBN cord-015365-iqdi99pd 2451 14 by by IN cord-015365-iqdi99pd 2451 15 a a DT cord-015365-iqdi99pd 2451 16 pathological pathological JJ cord-015365-iqdi99pd 2451 17 dilation dilation NN cord-015365-iqdi99pd 2451 18 of of IN cord-015365-iqdi99pd 2451 19 the the DT cord-015365-iqdi99pd 2451 20 trachea trachea NN cord-015365-iqdi99pd 2451 21 and and CC cord-015365-iqdi99pd 2451 22 the the DT cord-015365-iqdi99pd 2451 23 bronchial bronchial JJ cord-015365-iqdi99pd 2451 24 system system NN cord-015365-iqdi99pd 2451 25 . . . cord-015365-iqdi99pd 2452 1 The the DT cord-015365-iqdi99pd 2452 2 etiology etiology NN cord-015365-iqdi99pd 2452 3 of of IN cord-015365-iqdi99pd 2452 4 the the DT cord-015365-iqdi99pd 2452 5 disorder disorder NN cord-015365-iqdi99pd 2452 6 remains remain VBZ cord-015365-iqdi99pd 2452 7 elusive elusive JJ cord-015365-iqdi99pd 2452 8 but but CC cord-015365-iqdi99pd 2452 9 genetic genetic JJ cord-015365-iqdi99pd 2452 10 alterations alteration NNS cord-015365-iqdi99pd 2452 11 and and CC cord-015365-iqdi99pd 2452 12 degradation degradation NN cord-015365-iqdi99pd 2452 13 of of IN cord-015365-iqdi99pd 2452 14 elastic elastic JJ cord-015365-iqdi99pd 2452 15 fibers fiber NNS cord-015365-iqdi99pd 2452 16 are be VBP cord-015365-iqdi99pd 2452 17 thought think VBN cord-015365-iqdi99pd 2452 18 to to TO cord-015365-iqdi99pd 2452 19 be be VB cord-015365-iqdi99pd 2452 20 involved involve VBN cord-015365-iqdi99pd 2452 21 in in IN cord-015365-iqdi99pd 2452 22 the the DT cord-015365-iqdi99pd 2452 23 pathogenesis pathogenesis NN cord-015365-iqdi99pd 2452 24 . . . cord-015365-iqdi99pd 2453 1 No no DT cord-015365-iqdi99pd 2453 2 causative causative JJ cord-015365-iqdi99pd 2453 3 treatment treatment NN cord-015365-iqdi99pd 2453 4 is be VBZ cord-015365-iqdi99pd 2453 5 available available JJ cord-015365-iqdi99pd 2453 6 although although IN cord-015365-iqdi99pd 2453 7 transplantation transplantation NN cord-015365-iqdi99pd 2453 8 is be VBZ cord-015365-iqdi99pd 2453 9 an an DT cord-015365-iqdi99pd 2453 10 option option NN cord-015365-iqdi99pd 2453 11 for for IN cord-015365-iqdi99pd 2453 12 endstage endstage NN cord-015365-iqdi99pd 2453 13 disease disease NN cord-015365-iqdi99pd 2453 14 . . . cord-015365-iqdi99pd 2454 1 Here here RB cord-015365-iqdi99pd 2454 2 , , , cord-015365-iqdi99pd 2454 3 we -PRON- PRP cord-015365-iqdi99pd 2454 4 describe describe VBP cord-015365-iqdi99pd 2454 5 a a DT cord-015365-iqdi99pd 2454 6 patient patient NN cord-015365-iqdi99pd 2454 7 suffering suffer VBG cord-015365-iqdi99pd 2454 8 from from IN cord-015365-iqdi99pd 2454 9 MKS MKS NNP cord-015365-iqdi99pd 2454 10 who who WP cord-015365-iqdi99pd 2454 11 received receive VBD cord-015365-iqdi99pd 2454 12 a a DT cord-015365-iqdi99pd 2454 13 lung lung NN cord-015365-iqdi99pd 2454 14 transplant transplant NN cord-015365-iqdi99pd 2454 15 at at IN cord-015365-iqdi99pd 2454 16 our -PRON- PRP$ cord-015365-iqdi99pd 2454 17 department department NN cord-015365-iqdi99pd 2454 18 . . . cord-015365-iqdi99pd 2455 1 Methods method NNS cord-015365-iqdi99pd 2455 2 . . . cord-015365-iqdi99pd 2456 1 A a DT cord-015365-iqdi99pd 2456 2 39-year 39-year JJ cord-015365-iqdi99pd 2456 3 - - HYPH cord-015365-iqdi99pd 2456 4 old old JJ cord-015365-iqdi99pd 2456 5 male male JJ cord-015365-iqdi99pd 2456 6 never never RB cord-015365-iqdi99pd 2456 7 - - HYPH cord-015365-iqdi99pd 2456 8 smoker smoker NN cord-015365-iqdi99pd 2456 9 presented present VBN cord-015365-iqdi99pd 2456 10 at at IN cord-015365-iqdi99pd 2456 11 our -PRON- PRP$ cord-015365-iqdi99pd 2456 12 department department NN cord-015365-iqdi99pd 2456 13 for for IN cord-015365-iqdi99pd 2456 14 evaluation evaluation NN cord-015365-iqdi99pd 2456 15 for for IN cord-015365-iqdi99pd 2456 16 a a DT cord-015365-iqdi99pd 2456 17 lung lung NN cord-015365-iqdi99pd 2456 18 transplantat transplantat NN cord-015365-iqdi99pd 2456 19 . . . cord-015365-iqdi99pd 2457 1 The the DT cord-015365-iqdi99pd 2457 2 patient patient NN cord-015365-iqdi99pd 2457 3 suffered suffer VBD cord-015365-iqdi99pd 2457 4 from from IN cord-015365-iqdi99pd 2457 5 Mounier Mounier NNP cord-015365-iqdi99pd 2457 6 - - HYPH cord-015365-iqdi99pd 2457 7 Kuhn Kuhn NNP cord-015365-iqdi99pd 2457 8 syndrome syndrome NN cord-015365-iqdi99pd 2457 9 ( ( -LRB- cord-015365-iqdi99pd 2457 10 MKS MKS NNP cord-015365-iqdi99pd 2457 11 ) ) -RRB- cord-015365-iqdi99pd 2457 12 with with IN cord-015365-iqdi99pd 2457 13 greatly greatly RB cord-015365-iqdi99pd 2457 14 dilated dilated JJ cord-015365-iqdi99pd 2457 15 trachea trachea NN cord-015365-iqdi99pd 2457 16 and and CC cord-015365-iqdi99pd 2457 17 bronchi bronchi NN cord-015365-iqdi99pd 2457 18 . . . cord-015365-iqdi99pd 2458 1 Since since IN cord-015365-iqdi99pd 2458 2 a a DT cord-015365-iqdi99pd 2458 3 familial familial JJ cord-015365-iqdi99pd 2458 4 clustering clustering NN cord-015365-iqdi99pd 2458 5 of of IN cord-015365-iqdi99pd 2458 6 Mounier Mounier NNP cord-015365-iqdi99pd 2458 7 - - HYPH cord-015365-iqdi99pd 2458 8 Kuhn Kuhn NNP cord-015365-iqdi99pd 2458 9 syndrome syndrome NN cord-015365-iqdi99pd 2458 10 is be VBZ cord-015365-iqdi99pd 2458 11 discussed discuss VBN cord-015365-iqdi99pd 2458 12 in in IN cord-015365-iqdi99pd 2458 13 the the DT cord-015365-iqdi99pd 2458 14 literature literature NN cord-015365-iqdi99pd 2458 15 , , , cord-015365-iqdi99pd 2458 16 we -PRON- PRP cord-015365-iqdi99pd 2458 17 performed perform VBD cord-015365-iqdi99pd 2458 18 a a DT cord-015365-iqdi99pd 2458 19 chromosomal chromosomal JJ cord-015365-iqdi99pd 2458 20 analysis analysis NN cord-015365-iqdi99pd 2458 21 and and CC cord-015365-iqdi99pd 2458 22 an an DT cord-015365-iqdi99pd 2458 23 array array NN cord-015365-iqdi99pd 2458 24 - - HYPH cord-015365-iqdi99pd 2458 25 CGH CGH NNP cord-015365-iqdi99pd 2458 26 to to TO cord-015365-iqdi99pd 2458 27 search search VB cord-015365-iqdi99pd 2458 28 for for IN cord-015365-iqdi99pd 2458 29 genetic genetic JJ cord-015365-iqdi99pd 2458 30 abnormalities abnormality NNS cord-015365-iqdi99pd 2458 31 . . . cord-015365-iqdi99pd 2459 1 At at IN cord-015365-iqdi99pd 2459 2 the the DT cord-015365-iqdi99pd 2459 3 time time NN cord-015365-iqdi99pd 2459 4 of of IN cord-015365-iqdi99pd 2459 5 transplantation transplantation NN cord-015365-iqdi99pd 2459 6 we -PRON- PRP cord-015365-iqdi99pd 2459 7 collected collect VBD cord-015365-iqdi99pd 2459 8 samples sample NNS cord-015365-iqdi99pd 2459 9 from from IN cord-015365-iqdi99pd 2459 10 the the DT cord-015365-iqdi99pd 2459 11 bronchi bronchi NN cord-015365-iqdi99pd 2459 12 and and CC cord-015365-iqdi99pd 2459 13 performed perform VBD cord-015365-iqdi99pd 2459 14 hematoxylin hematoxylin NNP cord-015365-iqdi99pd 2459 15 and and CC cord-015365-iqdi99pd 2459 16 eosin eosin NNP cord-015365-iqdi99pd 2459 17 ( ( -LRB- cord-015365-iqdi99pd 2459 18 HE HE NNP cord-015365-iqdi99pd 2459 19 ) ) -RRB- cord-015365-iqdi99pd 2459 20 , , , cord-015365-iqdi99pd 2459 21 Elastic Elastic NNP cord-015365-iqdi99pd 2459 22 van van NNP cord-015365-iqdi99pd 2459 23 - - HYPH cord-015365-iqdi99pd 2459 24 Gieson Gieson NNP cord-015365-iqdi99pd 2459 25 's 's POS cord-015365-iqdi99pd 2459 26 ( ( -LRB- cord-015365-iqdi99pd 2459 27 EVG EVG NNP cord-015365-iqdi99pd 2459 28 ) ) -RRB- cord-015365-iqdi99pd 2459 29 and and CC cord-015365-iqdi99pd 2459 30 immunohistochemical immunohistochemical JJ cord-015365-iqdi99pd 2459 31 stains stain NNS cord-015365-iqdi99pd 2459 32 . . . cord-015365-iqdi99pd 2460 1 Specimens specimen NNS cord-015365-iqdi99pd 2460 2 of of IN cord-015365-iqdi99pd 2460 3 main main JJ cord-015365-iqdi99pd 2460 4 bronchi bronchi NN cord-015365-iqdi99pd 2460 5 from from IN cord-015365-iqdi99pd 2460 6 the the DT cord-015365-iqdi99pd 2460 7 donor donor NN cord-015365-iqdi99pd 2460 8 lung lung NN cord-015365-iqdi99pd 2460 9 harvested harvest VBN cord-015365-iqdi99pd 2460 10 for for IN cord-015365-iqdi99pd 2460 11 transplant transplant NN cord-015365-iqdi99pd 2460 12 served serve VBD cord-015365-iqdi99pd 2460 13 as as IN cord-015365-iqdi99pd 2460 14 control control NN cord-015365-iqdi99pd 2460 15 . . . cord-015365-iqdi99pd 2461 1 Results result NNS cord-015365-iqdi99pd 2461 2 . . . cord-015365-iqdi99pd 2462 1 The the DT cord-015365-iqdi99pd 2462 2 chromosomal chromosomal JJ cord-015365-iqdi99pd 2462 3 analysis analysis NN cord-015365-iqdi99pd 2462 4 and and CC cord-015365-iqdi99pd 2462 5 array array NN cord-015365-iqdi99pd 2462 6 - - HYPH cord-015365-iqdi99pd 2462 7 CGH CGH NNP cord-015365-iqdi99pd 2462 8 revealed reveal VBD cord-015365-iqdi99pd 2462 9 that that IN cord-015365-iqdi99pd 2462 10 the the DT cord-015365-iqdi99pd 2462 11 patient patient NN cord-015365-iqdi99pd 2462 12 's 's POS cord-015365-iqdi99pd 2462 13 genome genome NN cord-015365-iqdi99pd 2462 14 was be VBD cord-015365-iqdi99pd 2462 15 completely completely RB cord-015365-iqdi99pd 2462 16 unremarkable unremarkable JJ cord-015365-iqdi99pd 2462 17 , , , cord-015365-iqdi99pd 2462 18 the the DT cord-015365-iqdi99pd 2462 19 karyogram karyogram NN cord-015365-iqdi99pd 2462 20 as as RB cord-015365-iqdi99pd 2462 21 well well RB cord-015365-iqdi99pd 2462 22 as as IN cord-015365-iqdi99pd 2462 23 the the DT cord-015365-iqdi99pd 2462 24 genome genome NN cord-015365-iqdi99pd 2462 25 hybridization hybridization NN cord-015365-iqdi99pd 2462 26 showed show VBD cord-015365-iqdi99pd 2462 27 no no DT cord-015365-iqdi99pd 2462 28 significant significant JJ cord-015365-iqdi99pd 2462 29 gain gain NN cord-015365-iqdi99pd 2462 30 or or CC cord-015365-iqdi99pd 2462 31 loss loss NN cord-015365-iqdi99pd 2462 32 in in IN cord-015365-iqdi99pd 2462 33 known know VBN cord-015365-iqdi99pd 2462 34 encoding encoding NN cord-015365-iqdi99pd 2462 35 regions region NNS cord-015365-iqdi99pd 2462 36 . . . cord-015365-iqdi99pd 2463 1 Through through IN cord-015365-iqdi99pd 2463 2 the the DT cord-015365-iqdi99pd 2463 3 histological histological JJ cord-015365-iqdi99pd 2463 4 evaluation evaluation NN cord-015365-iqdi99pd 2463 5 we -PRON- PRP cord-015365-iqdi99pd 2463 6 found find VBD cord-015365-iqdi99pd 2463 7 considerably considerably RB cord-015365-iqdi99pd 2463 8 lower low JJR cord-015365-iqdi99pd 2463 9 amounts amount NNS cord-015365-iqdi99pd 2463 10 of of IN cord-015365-iqdi99pd 2463 11 elastic elastic JJ cord-015365-iqdi99pd 2463 12 and and CC cord-015365-iqdi99pd 2463 13 collagen collagen NN cord-015365-iqdi99pd 2463 14 fibers fiber NNS cord-015365-iqdi99pd 2463 15 in in IN cord-015365-iqdi99pd 2463 16 the the DT cord-015365-iqdi99pd 2463 17 submucosal submucosal NNP cord-015365-iqdi99pd 2463 18 layer layer NN cord-015365-iqdi99pd 2463 19 in in IN cord-015365-iqdi99pd 2463 20 the the DT cord-015365-iqdi99pd 2463 21 patient patient NN cord-015365-iqdi99pd 2463 22 compared compare VBN cord-015365-iqdi99pd 2463 23 to to IN cord-015365-iqdi99pd 2463 24 healthy healthy JJ cord-015365-iqdi99pd 2463 25 controls control NNS cord-015365-iqdi99pd 2463 26 . . . cord-015365-iqdi99pd 2464 1 Furthermore furthermore RB cord-015365-iqdi99pd 2464 2 inflammatory inflammatory JJ cord-015365-iqdi99pd 2464 3 infiltrates infiltrate NNS cord-015365-iqdi99pd 2464 4 were be VBD cord-015365-iqdi99pd 2464 5 present present JJ cord-015365-iqdi99pd 2464 6 in in IN cord-015365-iqdi99pd 2464 7 the the DT cord-015365-iqdi99pd 2464 8 connective connective JJ cord-015365-iqdi99pd 2464 9 tissue tissue NN cord-015365-iqdi99pd 2464 10 throughout throughout IN cord-015365-iqdi99pd 2464 11 the the DT cord-015365-iqdi99pd 2464 12 whole whole JJ cord-015365-iqdi99pd 2464 13 histological histological JJ cord-015365-iqdi99pd 2464 14 specimen specimen NN cord-015365-iqdi99pd 2464 15 . . . cord-015365-iqdi99pd 2465 1 Since since IN cord-015365-iqdi99pd 2465 2 chronic chronic JJ cord-015365-iqdi99pd 2465 3 inflammation inflammation NN cord-015365-iqdi99pd 2465 4 is be VBZ cord-015365-iqdi99pd 2465 5 known know VBN cord-015365-iqdi99pd 2465 6 to to TO cord-015365-iqdi99pd 2465 7 result result VB cord-015365-iqdi99pd 2465 8 in in IN cord-015365-iqdi99pd 2465 9 tissue tissue NN cord-015365-iqdi99pd 2465 10 remodeling remodeling NN cord-015365-iqdi99pd 2465 11 we -PRON- PRP cord-015365-iqdi99pd 2465 12 performed perform VBD cord-015365-iqdi99pd 2465 13 immunohistological immunohistological JJ cord-015365-iqdi99pd 2465 14 staining staining NN cord-015365-iqdi99pd 2465 15 of of IN cord-015365-iqdi99pd 2465 16 different different JJ cord-015365-iqdi99pd 2465 17 matrix matrix NN cord-015365-iqdi99pd 2465 18 metalloproteinases metalloproteinase NNS cord-015365-iqdi99pd 2465 19 . . . cord-015365-iqdi99pd 2466 1 MMP1 MMP1 NNP cord-015365-iqdi99pd 2466 2 , , , cord-015365-iqdi99pd 2466 3 MMP2 MMP2 NNP cord-015365-iqdi99pd 2466 4 , , , cord-015365-iqdi99pd 2466 5 MMP3 MMP3 NNP cord-015365-iqdi99pd 2466 6 and and CC cord-015365-iqdi99pd 2466 7 MMP9 MMP9 NNP cord-015365-iqdi99pd 2466 8 were be VBD cord-015365-iqdi99pd 2466 9 detected detect VBN cord-015365-iqdi99pd 2466 10 in in IN cord-015365-iqdi99pd 2466 11 MKS MKS NNP cord-015365-iqdi99pd 2466 12 tissue tissue NN cord-015365-iqdi99pd 2466 13 , , , cord-015365-iqdi99pd 2466 14 but but CC cord-015365-iqdi99pd 2466 15 were be VBD cord-015365-iqdi99pd 2466 16 totally totally RB cord-015365-iqdi99pd 2466 17 absent absent JJ cord-015365-iqdi99pd 2466 18 in in IN cord-015365-iqdi99pd 2466 19 control control NN cord-015365-iqdi99pd 2466 20 bronchi bronchi NN cord-015365-iqdi99pd 2466 21 . . . cord-015365-iqdi99pd 2467 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2467 2 . . . cord-015365-iqdi99pd 2468 1 Based base VBN cord-015365-iqdi99pd 2468 2 on on IN cord-015365-iqdi99pd 2468 3 these these DT cord-015365-iqdi99pd 2468 4 findings finding NNS cord-015365-iqdi99pd 2468 5 we -PRON- PRP cord-015365-iqdi99pd 2468 6 hypothesize hypothesize VBP cord-015365-iqdi99pd 2468 7 that that IN cord-015365-iqdi99pd 2468 8 the the DT cord-015365-iqdi99pd 2468 9 pathophysiology pathophysiology NN cord-015365-iqdi99pd 2468 10 of of IN cord-015365-iqdi99pd 2468 11 MKS MKS NNP cord-015365-iqdi99pd 2468 12 is be VBZ cord-015365-iqdi99pd 2468 13 of of IN cord-015365-iqdi99pd 2468 14 a a DT cord-015365-iqdi99pd 2468 15 chronic chronic JJ cord-015365-iqdi99pd 2468 16 inflammatory inflammatory JJ cord-015365-iqdi99pd 2468 17 type type NN cord-015365-iqdi99pd 2468 18 leading lead VBG cord-015365-iqdi99pd 2468 19 to to IN cord-015365-iqdi99pd 2468 20 tissue tissue NN cord-015365-iqdi99pd 2468 21 destruction destruction NN cord-015365-iqdi99pd 2468 22 and and CC cord-015365-iqdi99pd 2468 23 a a DT cord-015365-iqdi99pd 2468 24 loss loss NN cord-015365-iqdi99pd 2468 25 of of IN cord-015365-iqdi99pd 2468 26 elastic elastic JJ cord-015365-iqdi99pd 2468 27 fibers fiber NNS cord-015365-iqdi99pd 2468 28 , , , cord-015365-iqdi99pd 2468 29 possibly possibly RB cord-015365-iqdi99pd 2468 30 due due IN cord-015365-iqdi99pd 2468 31 to to IN cord-015365-iqdi99pd 2468 32 upregulation upregulation NN cord-015365-iqdi99pd 2468 33 of of IN cord-015365-iqdi99pd 2468 34 MMP MMP NNP cord-015365-iqdi99pd 2468 35 . . . cord-015365-iqdi99pd 2469 1 The the DT cord-015365-iqdi99pd 2469 2 triggering trigger VBG cord-015365-iqdi99pd 2469 3 mechanism(s mechanism(s NN cord-015365-iqdi99pd 2469 4 ) ) -RRB- cord-015365-iqdi99pd 2469 5 for for IN cord-015365-iqdi99pd 2469 6 this this DT cord-015365-iqdi99pd 2469 7 inflammatory inflammatory JJ cord-015365-iqdi99pd 2469 8 reaction reaction NN cord-015365-iqdi99pd 2469 9 remain remain VBP cord-015365-iqdi99pd 2469 10 elusive elusive JJ cord-015365-iqdi99pd 2469 11 , , , cord-015365-iqdi99pd 2469 12 but but CC cord-015365-iqdi99pd 2469 13 since since IN cord-015365-iqdi99pd 2469 14 MKS MKS NNP cord-015365-iqdi99pd 2469 15 has have VBZ cord-015365-iqdi99pd 2469 16 been be VBN cord-015365-iqdi99pd 2469 17 reported report VBN cord-015365-iqdi99pd 2469 18 to to TO cord-015365-iqdi99pd 2469 19 be be VB cord-015365-iqdi99pd 2469 20 associated associate VBN cord-015365-iqdi99pd 2469 21 with with IN cord-015365-iqdi99pd 2469 22 autoimmune autoimmune JJ cord-015365-iqdi99pd 2469 23 diseases disease NNS cord-015365-iqdi99pd 2469 24 , , , cord-015365-iqdi99pd 2469 25 an an DT cord-015365-iqdi99pd 2469 26 autoimmune autoimmune JJ cord-015365-iqdi99pd 2469 27 reaction reaction NN cord-015365-iqdi99pd 2469 28 against against IN cord-015365-iqdi99pd 2469 29 components component NNS cord-015365-iqdi99pd 2469 30 of of IN cord-015365-iqdi99pd 2469 31 the the DT cord-015365-iqdi99pd 2469 32 major major JJ cord-015365-iqdi99pd 2469 33 airways airway NNS cord-015365-iqdi99pd 2469 34 could could MD cord-015365-iqdi99pd 2469 35 be be VB cord-015365-iqdi99pd 2469 36 one one CD cord-015365-iqdi99pd 2469 37 possible possible JJ cord-015365-iqdi99pd 2469 38 explanation explanation NN cord-015365-iqdi99pd 2469 39 . . . cord-015365-iqdi99pd 2470 1 Background background NN cord-015365-iqdi99pd 2470 2 . . . cord-015365-iqdi99pd 2471 1 Lung lung NN cord-015365-iqdi99pd 2471 2 transplant transplant NN cord-015365-iqdi99pd 2471 3 recipients recipient NNS cord-015365-iqdi99pd 2471 4 ( ( -LRB- cord-015365-iqdi99pd 2471 5 LTRs LTRs NNP cord-015365-iqdi99pd 2471 6 ) ) -RRB- cord-015365-iqdi99pd 2471 7 are be VBP cord-015365-iqdi99pd 2471 8 uniquely uniquely RB cord-015365-iqdi99pd 2471 9 predisposed predisposed JJ cord-015365-iqdi99pd 2471 10 in in IN cord-015365-iqdi99pd 2471 11 developing develop VBG cord-015365-iqdi99pd 2471 12 severe severe JJ cord-015365-iqdi99pd 2471 13 complications complication NNS cord-015365-iqdi99pd 2471 14 associated associate VBN cord-015365-iqdi99pd 2471 15 with with IN cord-015365-iqdi99pd 2471 16 community community NN cord-015365-iqdi99pd 2471 17 acquired acquire VBD cord-015365-iqdi99pd 2471 18 respiratory respiratory JJ cord-015365-iqdi99pd 2471 19 viral viral JJ cord-015365-iqdi99pd 2471 20 infections infection NNS cord-015365-iqdi99pd 2471 21 ( ( -LRB- cord-015365-iqdi99pd 2471 22 CARV CARV NNP cord-015365-iqdi99pd 2471 23 ) ) -RRB- cord-015365-iqdi99pd 2471 24 . . . cord-015365-iqdi99pd 2472 1 We -PRON- PRP cord-015365-iqdi99pd 2472 2 report report VBP cord-015365-iqdi99pd 2472 3 the the DT cord-015365-iqdi99pd 2472 4 outcomes outcome NNS cord-015365-iqdi99pd 2472 5 of of IN cord-015365-iqdi99pd 2472 6 influenza influenza NN cord-015365-iqdi99pd 2472 7 infections infection NNS cord-015365-iqdi99pd 2472 8 in in IN cord-015365-iqdi99pd 2472 9 a a DT cord-015365-iqdi99pd 2472 10 cohort cohort NN cord-015365-iqdi99pd 2472 11 of of IN cord-015365-iqdi99pd 2472 12 82 82 CD cord-015365-iqdi99pd 2472 13 screened screen VBN cord-015365-iqdi99pd 2472 14 lung lung NN cord-015365-iqdi99pd 2472 15 transplant transplant NN cord-015365-iqdi99pd 2472 16 recipients recipient NNS cord-015365-iqdi99pd 2472 17 at at IN cord-015365-iqdi99pd 2472 18 our -PRON- PRP$ cord-015365-iqdi99pd 2472 19 center center NN cord-015365-iqdi99pd 2472 20 . . . cord-015365-iqdi99pd 2473 1 Methods method NNS cord-015365-iqdi99pd 2473 2 . . . cord-015365-iqdi99pd 2474 1 Data datum NNS cord-015365-iqdi99pd 2474 2 were be VBD cord-015365-iqdi99pd 2474 3 collected collect VBN cord-015365-iqdi99pd 2474 4 from from IN cord-015365-iqdi99pd 2474 5 December December NNP cord-015365-iqdi99pd 2474 6 2010 2010 CD cord-015365-iqdi99pd 2474 7 to to IN cord-015365-iqdi99pd 2474 8 March March NNP cord-015365-iqdi99pd 2474 9 2011 2011 CD cord-015365-iqdi99pd 2474 10 on on IN cord-015365-iqdi99pd 2474 11 using use VBG cord-015365-iqdi99pd 2474 12 real real JJ cord-015365-iqdi99pd 2474 13 - - HYPH cord-015365-iqdi99pd 2474 14 time time NN cord-015365-iqdi99pd 2474 15 polymerase polymerase NN cord-015365-iqdi99pd 2474 16 chain chain NN cord-015365-iqdi99pd 2474 17 reaction reaction NN cord-015365-iqdi99pd 2474 18 ( ( -LRB- cord-015365-iqdi99pd 2474 19 PCR PCR NNP cord-015365-iqdi99pd 2474 20 ) ) -RRB- cord-015365-iqdi99pd 2474 21 from from IN cord-015365-iqdi99pd 2474 22 nasal nasal JJ cord-015365-iqdi99pd 2474 23 secretion secretion NN cord-015365-iqdi99pd 2474 24 . . . cord-015365-iqdi99pd 2475 1 During during IN cord-015365-iqdi99pd 2475 2 this this DT cord-015365-iqdi99pd 2475 3 period period NN cord-015365-iqdi99pd 2475 4 245 245 CD cord-015365-iqdi99pd 2475 5 patients patient NNS cord-015365-iqdi99pd 2475 6 frequented frequent VBD cord-015365-iqdi99pd 2475 7 our -PRON- PRP$ cord-015365-iqdi99pd 2475 8 out out JJ cord-015365-iqdi99pd 2475 9 patient patient JJ cord-015365-iqdi99pd 2475 10 department department NN cord-015365-iqdi99pd 2475 11 for for IN cord-015365-iqdi99pd 2475 12 thoracic thoracic JJ cord-015365-iqdi99pd 2475 13 surgery surgery NN cord-015365-iqdi99pd 2475 14 . . . cord-015365-iqdi99pd 2476 1 All all DT cord-015365-iqdi99pd 2476 2 LTRs LTRs NNPS cord-015365-iqdi99pd 2476 3 ( ( -LRB- cord-015365-iqdi99pd 2476 4 n n CC cord-015365-iqdi99pd 2476 5 ¼ ¼ NNP cord-015365-iqdi99pd 2476 6 82 82 CD cord-015365-iqdi99pd 2476 7 ) ) -RRB- cord-015365-iqdi99pd 2476 8 with with IN cord-015365-iqdi99pd 2476 9 respiratory respiratory JJ cord-015365-iqdi99pd 2476 10 symptoms symptom NNS cord-015365-iqdi99pd 2476 11 were be VBD cord-015365-iqdi99pd 2476 12 screened screen VBN cord-015365-iqdi99pd 2476 13 . . . cord-015365-iqdi99pd 2477 1 There there EX cord-015365-iqdi99pd 2477 2 were be VBD cord-015365-iqdi99pd 2477 3 9 9 CD cord-015365-iqdi99pd 2477 4 ( ( -LRB- cord-015365-iqdi99pd 2477 5 10 10 CD cord-015365-iqdi99pd 2477 6 , , , cord-015365-iqdi99pd 2477 7 9 9 CD cord-015365-iqdi99pd 2477 8 % % NN cord-015365-iqdi99pd 2477 9 ) ) -RRB- cord-015365-iqdi99pd 2477 10 confirmed confirm VBD cord-015365-iqdi99pd 2477 11 cases case NNS cord-015365-iqdi99pd 2477 12 . . . cord-015365-iqdi99pd 2478 1 H1N1 H1N1 NNP cord-015365-iqdi99pd 2478 2 infection infection NN cord-015365-iqdi99pd 2478 3 was be VBD cord-015365-iqdi99pd 2478 4 diagnosed diagnose VBN cord-015365-iqdi99pd 2478 5 in in IN cord-015365-iqdi99pd 2478 6 5 5 CD cord-015365-iqdi99pd 2478 7 , , , cord-015365-iqdi99pd 2478 8 influenza influenza NN cord-015365-iqdi99pd 2478 9 B b NN cord-015365-iqdi99pd 2478 10 in in IN cord-015365-iqdi99pd 2478 11 4 4 CD cord-015365-iqdi99pd 2478 12 lung lung NN cord-015365-iqdi99pd 2478 13 transplant transplant NN cord-015365-iqdi99pd 2478 14 recipients recipient NNS cord-015365-iqdi99pd 2478 15 , , , cord-015365-iqdi99pd 2478 16 median median NN cord-015365-iqdi99pd 2478 17 age age NN cord-015365-iqdi99pd 2478 18 36 36 CD cord-015365-iqdi99pd 2478 19 ( ( -LRB- cord-015365-iqdi99pd 2478 20 26 26 CD cord-015365-iqdi99pd 2478 21 - - SYM cord-015365-iqdi99pd 2478 22 65 65 CD cord-015365-iqdi99pd 2478 23 ) ) -RRB- cord-015365-iqdi99pd 2478 24 years year NNS cord-015365-iqdi99pd 2478 25 , , , cord-015365-iqdi99pd 2478 26 with with IN cord-015365-iqdi99pd 2478 27 a a DT cord-015365-iqdi99pd 2478 28 median median NN cord-015365-iqdi99pd 2478 29 of of IN cord-015365-iqdi99pd 2478 30 6 6 CD cord-015365-iqdi99pd 2478 31 ( ( -LRB- cord-015365-iqdi99pd 2478 32 1,1 1,1 CD cord-015365-iqdi99pd 2478 33 - - SYM cord-015365-iqdi99pd 2478 34 12 12 CD cord-015365-iqdi99pd 2478 35 ) ) -RRB- cord-015365-iqdi99pd 2478 36 years year NNS cord-015365-iqdi99pd 2478 37 post post NN cord-015365-iqdi99pd 2478 38 lung lung NN cord-015365-iqdi99pd 2478 39 transplantation transplantation NN cord-015365-iqdi99pd 2478 40 . . . cord-015365-iqdi99pd 2479 1 Results result NNS cord-015365-iqdi99pd 2479 2 . . . cord-015365-iqdi99pd 2480 1 All all DT cord-015365-iqdi99pd 2480 2 patients patient NNS cord-015365-iqdi99pd 2480 3 with with IN cord-015365-iqdi99pd 2480 4 BOS BOS NNP cord-015365-iqdi99pd 2480 5 grade grade NN cord-015365-iqdi99pd 2480 6 0 0 NFP cord-015365-iqdi99pd 2480 7 ( ( -LRB- cord-015365-iqdi99pd 2480 8 bronchiolitis bronchiolitis NNP cord-015365-iqdi99pd 2480 9 obliterans obliterans NNP cord-015365-iqdi99pd 2480 10 syndrome syndrome NNP cord-015365-iqdi99pd 2480 11 , , , cord-015365-iqdi99pd 2480 12 n n NN cord-015365-iqdi99pd 2480 13 ¼ ¼ NNP cord-015365-iqdi99pd 2480 14 5 5 CD cord-015365-iqdi99pd 2480 15 ) ) -RRB- cord-015365-iqdi99pd 2480 16 were be VBD cord-015365-iqdi99pd 2480 17 treated treat VBN cord-015365-iqdi99pd 2480 18 symptomatically symptomatically RB cord-015365-iqdi99pd 2480 19 alone alone JJ cord-015365-iqdi99pd 2480 20 , , , cord-015365-iqdi99pd 2480 21 with with IN cord-015365-iqdi99pd 2480 22 no no DT cord-015365-iqdi99pd 2480 23 further further JJ cord-015365-iqdi99pd 2480 24 impact impact NN cord-015365-iqdi99pd 2480 25 on on IN cord-015365-iqdi99pd 2480 26 their -PRON- PRP$ cord-015365-iqdi99pd 2480 27 lung lung NN cord-015365-iqdi99pd 2480 28 function function NN cord-015365-iqdi99pd 2480 29 . . . cord-015365-iqdi99pd 2481 1 Two two CD cord-015365-iqdi99pd 2481 2 patients patient NNS cord-015365-iqdi99pd 2481 3 of of IN cord-015365-iqdi99pd 2481 4 this this DT cord-015365-iqdi99pd 2481 5 group group NN cord-015365-iqdi99pd 2481 6 were be VBD cord-015365-iqdi99pd 2481 7 vaccinated vaccinate VBN cord-015365-iqdi99pd 2481 8 for for IN cord-015365-iqdi99pd 2481 9 seasonal seasonal JJ cord-015365-iqdi99pd 2481 10 influenza influenza NN cord-015365-iqdi99pd 2481 11 . . . cord-015365-iqdi99pd 2482 1 Among among IN cord-015365-iqdi99pd 2482 2 the the DT cord-015365-iqdi99pd 2482 3 group group NN cord-015365-iqdi99pd 2482 4 of of IN cord-015365-iqdi99pd 2482 5 patients patient NNS cord-015365-iqdi99pd 2482 6 with with IN cord-015365-iqdi99pd 2482 7 pre pre JJ cord-015365-iqdi99pd 2482 8 - - JJ cord-015365-iqdi99pd 2482 9 existing existing JJ cord-015365-iqdi99pd 2482 10 BOS BOS NNP cord-015365-iqdi99pd 2482 11 ( ( -LRB- cord-015365-iqdi99pd 2482 12 n n NN cord-015365-iqdi99pd 2482 13 ¼ ¼ NNP cord-015365-iqdi99pd 2482 14 4 4 CD cord-015365-iqdi99pd 2482 15 ) ) -RRB- cord-015365-iqdi99pd 2482 16 , , , cord-015365-iqdi99pd 2482 17 two two CD cord-015365-iqdi99pd 2482 18 lung lung NN cord-015365-iqdi99pd 2482 19 transplant transplant NN cord-015365-iqdi99pd 2482 20 recipients recipient NNS cord-015365-iqdi99pd 2482 21 , , , cord-015365-iqdi99pd 2482 22 one one CD cord-015365-iqdi99pd 2482 23 with with IN cord-015365-iqdi99pd 2482 24 BOS BOS NNP cord-015365-iqdi99pd 2482 25 I I NNP cord-015365-iqdi99pd 2482 26 , , , cord-015365-iqdi99pd 2482 27 the the DT cord-015365-iqdi99pd 2482 28 other other JJ cord-015365-iqdi99pd 2482 29 with with IN cord-015365-iqdi99pd 2482 30 BOS BOS NNP cord-015365-iqdi99pd 2482 31 II II NNP cord-015365-iqdi99pd 2482 32 developed develop VBD cord-015365-iqdi99pd 2482 33 Grundlagen Grundlagen NNP cord-015365-iqdi99pd 2482 34 . . . cord-015365-iqdi99pd 2483 1 Eine Eine NNP cord-015365-iqdi99pd 2483 2 Vielzahl Vielzahl NNP cord-015365-iqdi99pd 2483 3 von von NNP cord-015365-iqdi99pd 2483 4 Medikamenten Medikamenten NNP cord-015365-iqdi99pd 2483 5 mit mit NNP cord-015365-iqdi99pd 2483 6 potentiell potentiell NNP cord-015365-iqdi99pd 2483 7 toxischen toxischen NNP cord-015365-iqdi99pd 2484 1 Nebenwirkungen Nebenwirkungen NNP cord-015365-iqdi99pd 2484 2 auf auf NNP cord-015365-iqdi99pd 2484 3 den den NNP cord-015365-iqdi99pd 2484 4 Respirationstrakt Respirationstrakt NNP cord-015365-iqdi99pd 2484 5 sind sind NNP cord-015365-iqdi99pd 2484 6 bekannt bekannt NNP cord-015365-iqdi99pd 2484 7 . . . cord-015365-iqdi99pd 2485 1 Zytotoxische Zytotoxische NNP cord-015365-iqdi99pd 2485 2 Substanzen Substanzen NNP cord-015365-iqdi99pd 2485 3 wie wie VBD cord-015365-iqdi99pd 2485 4 Methotrexat Methotrexat NNP cord-015365-iqdi99pd 2485 5 oder oder NN cord-015365-iqdi99pd 2485 6 Bleomycin Bleomycin NNP cord-015365-iqdi99pd 2486 1 und und NNP cord-015365-iqdi99pd 2486 2 andere andere NNP cord-015365-iqdi99pd 2486 3 Pharmaka Pharmaka NNP cord-015365-iqdi99pd 2487 1 wie wie NNP cord-015365-iqdi99pd 2487 2 Amiodaron Amiodaron NNP cord-015365-iqdi99pd 2487 3 oder oder NNP cord-015365-iqdi99pd 2488 1 diverse diverse JJ cord-015365-iqdi99pd 2488 2 Antibiotika Antibiotika NNP cord-015365-iqdi99pd 2488 3 werden werden NNP cord-015365-iqdi99pd 2488 4 am be VBP cord-015365-iqdi99pd 2488 5 häufigsten häufigsten NNP cord-015365-iqdi99pd 2488 6 als als NNP cord-015365-iqdi99pd 2489 1 Ursache Ursache NNP cord-015365-iqdi99pd 2490 1 fü fü IN cord-015365-iqdi99pd 2490 2 r r NNP cord-015365-iqdi99pd 2490 3 eine eine NNP cord-015365-iqdi99pd 2490 4 medikamentös medikamentös NNP cord-015365-iqdi99pd 2490 5 induzierte induzierte NNP cord-015365-iqdi99pd 2490 6 interstitielle interstitielle NNP cord-015365-iqdi99pd 2490 7 Lungenerkrankung Lungenerkrankung NNP cord-015365-iqdi99pd 2490 8 genannt genannt NNP cord-015365-iqdi99pd 2490 9 . . . cord-015365-iqdi99pd 2491 1 Methodik Methodik NNP cord-015365-iqdi99pd 2491 2 und und IN cord-015365-iqdi99pd 2491 3 Ergebnisse Ergebnisse NNP cord-015365-iqdi99pd 2491 4 . . . cord-015365-iqdi99pd 2492 1 Wir Wir NNP cord-015365-iqdi99pd 2492 2 berichten berichten NNP cord-015365-iqdi99pd 2492 3 den den NNP cord-015365-iqdi99pd 2492 4 Fall Fall NNP cord-015365-iqdi99pd 2492 5 eines eine NNS cord-015365-iqdi99pd 2493 1 64jährigen 64jährigen CD cord-015365-iqdi99pd 2494 1 Patienten Patienten NNP cord-015365-iqdi99pd 2494 2 , , , cord-015365-iqdi99pd 2494 3 der der NNP cord-015365-iqdi99pd 2494 4 i -PRON- PRP cord-015365-iqdi99pd 2494 5 m be VBP cord-015365-iqdi99pd 2494 6 Oktober Oktober NNP cord-015365-iqdi99pd 2494 7 2010 2010 CD cord-015365-iqdi99pd 2494 8 wegen wegen NNP cord-015365-iqdi99pd 2494 9 dilatativer dilatativer NNP cord-015365-iqdi99pd 2494 10 Kardiomypathie Kardiomypathie NNP cord-015365-iqdi99pd 2494 11 mit mit NNP cord-015365-iqdi99pd 2494 12 terminaler terminaler NNP cord-015365-iqdi99pd 2494 13 Herzinsuffizienz Herzinsuffizienz NNP cord-015365-iqdi99pd 2494 14 eine eine NNP cord-015365-iqdi99pd 2494 15 orthotope orthotope NN cord-015365-iqdi99pd 2494 16 Herztransplantation Herztransplantation NNP cord-015365-iqdi99pd 2494 17 erhielt erhielt NNP cord-015365-iqdi99pd 2494 18 . . . cord-015365-iqdi99pd 2495 1 Zu Zu NNP cord-015365-iqdi99pd 2495 2 diesem diesem NNP cord-015365-iqdi99pd 2495 3 Zeitpunkt Zeitpunkt NNP cord-015365-iqdi99pd 2495 4 bestand bestand NN cord-015365-iqdi99pd 2495 5 radiologisch radiologisch NNP cord-015365-iqdi99pd 2495 6 bereits bereits NNP cord-015365-iqdi99pd 2495 7 der der NNP cord-015365-iqdi99pd 2495 8 Verdacht Verdacht NNP cord-015365-iqdi99pd 2495 9 auf auf NNP cord-015365-iqdi99pd 2495 10 eine eine NNP cord-015365-iqdi99pd 2496 1 Amiodaron Amiodaron NNP cord-015365-iqdi99pd 2496 2 - - HYPH cord-015365-iqdi99pd 2496 3 induzierte induzierte NNS cord-015365-iqdi99pd 2496 4 Lungenfibrose Lungenfibrose NNP cord-015365-iqdi99pd 2496 5 mit mit VBP cord-015365-iqdi99pd 2496 6 funktionell funktionell NNP cord-015365-iqdi99pd 2496 7 reduzierten reduzierten NNP cord-015365-iqdi99pd 2496 8 Werten Werten NNP cord-015365-iqdi99pd 2496 9 : : : cord-015365-iqdi99pd 2496 10 VC VC NNP cord-015365-iqdi99pd 2496 11 3,49 3,49 NNP cord-015365-iqdi99pd 2496 12 l l NN cord-015365-iqdi99pd 2496 13 ( ( -LRB- cord-015365-iqdi99pd 2496 14 73 73 CD cord-015365-iqdi99pd 2496 15 % % NN cord-015365-iqdi99pd 2496 16 ) ) -RRB- cord-015365-iqdi99pd 2496 17 , , . cord-015365-iqdi99pd 2497 1 FEV1 FEV1 NNP cord-015365-iqdi99pd 2497 2 3,28 3,28 CD cord-015365-iqdi99pd 2497 3 l l NN cord-015365-iqdi99pd 2497 4 ( ( -LRB- cord-015365-iqdi99pd 2497 5 86 86 CD cord-015365-iqdi99pd 2497 6 % % NN cord-015365-iqdi99pd 2497 7 ) ) -RRB- cord-015365-iqdi99pd 2497 8 , , . cord-015365-iqdi99pd 2498 1 MEF50 mef50 JJ cord-015365-iqdi99pd 2499 1 6,52 6,52 NNP cord-015365-iqdi99pd 2499 2 l l NNP cord-015365-iqdi99pd 2499 3 ( ( -LRB- cord-015365-iqdi99pd 2499 4 135 135 CD cord-015365-iqdi99pd 2499 5 % % NN cord-015365-iqdi99pd 2499 6 ) ) -RRB- cord-015365-iqdi99pd 2499 7 und und RB cord-015365-iqdi99pd 2500 1 TLC TLC NNP cord-015365-iqdi99pd 2500 2 5,88 5,88 CD cord-015365-iqdi99pd 2500 3 l l NN cord-015365-iqdi99pd 2500 4 ( ( -LRB- cord-015365-iqdi99pd 2500 5 84 84 CD cord-015365-iqdi99pd 2500 6 % % NN cord-015365-iqdi99pd 2500 7 ) ) -RRB- cord-015365-iqdi99pd 2500 8 . . . cord-015365-iqdi99pd 2501 1 Der Der NNP cord-015365-iqdi99pd 2501 2 postoperative postoperative JJ cord-015365-iqdi99pd 2501 3 Verlauf Verlauf NNP cord-015365-iqdi99pd 2501 4 gestaltete gestaltete NNP cord-015365-iqdi99pd 2501 5 sich sich NNP cord-015365-iqdi99pd 2501 6 von von NNP cord-015365-iqdi99pd 2501 7 kardialer kardialer NNP cord-015365-iqdi99pd 2501 8 Seite Seite NNP cord-015365-iqdi99pd 2501 9 komplikationslos komplikationslos NNP cord-015365-iqdi99pd 2502 1 , , , cord-015365-iqdi99pd 2502 2 allerdings allerdings NNP cord-015365-iqdi99pd 2502 3 war war NN cord-015365-iqdi99pd 2502 4 der der NNP cord-015365-iqdi99pd 2502 5 Patient Patient NNP cord-015365-iqdi99pd 2502 6 respiratorisch respiratorisch NNP cord-015365-iqdi99pd 2502 7 stark stark NNP cord-015365-iqdi99pd 2502 8 limitiert limitiert NN cord-015365-iqdi99pd 2502 9 . . . cord-015365-iqdi99pd 2503 1 Der Der NNP cord-015365-iqdi99pd 2503 2 Weaningprozess Weaningprozess NNP cord-015365-iqdi99pd 2503 3 gestaltete gestaltete NN cord-015365-iqdi99pd 2503 4 sich sich NNP cord-015365-iqdi99pd 2503 5 aufgrund aufgrund NNP cord-015365-iqdi99pd 2503 6 einer einer NNP cord-015365-iqdi99pd 2503 7 Lobärpneumonie Lobärpneumonie NNP cord-015365-iqdi99pd 2503 8 protrahiert protrahiert NN cord-015365-iqdi99pd 2503 9 . . . cord-015365-iqdi99pd 2504 1 Auch Auch NNP cord-015365-iqdi99pd 2504 2 auf auf NNP cord-015365-iqdi99pd 2504 3 der der NNP cord-015365-iqdi99pd 2504 4 Normalstation Normalstation NNP cord-015365-iqdi99pd 2504 5 fiel fiel NNP cord-015365-iqdi99pd 2504 6 bei bei NNP cord-015365-iqdi99pd 2504 7 geringsten geringsten NNP cord-015365-iqdi99pd 2504 8 Belastungen Belastungen NNP cord-015365-iqdi99pd 2504 9 die die VBP cord-015365-iqdi99pd 2504 10 Sauerstoffsättigung Sauerstoffsättigung NNP cord-015365-iqdi99pd 2504 11 auf auf NN cord-015365-iqdi99pd 2504 12 bis bis NNP cord-015365-iqdi99pd 2504 13 zu zu NNP cord-015365-iqdi99pd 2504 14 87 87 CD cord-015365-iqdi99pd 2504 15 % % NN cord-015365-iqdi99pd 2504 16 . . . cord-015365-iqdi99pd 2505 1 Die die VB cord-015365-iqdi99pd 2505 2 Lungenfunktion lungenfunktion NN cord-015365-iqdi99pd 2505 3 2 2 CD cord-015365-iqdi99pd 2505 4 Monate monate NN cord-015365-iqdi99pd 2506 1 nach nach NNP cord-015365-iqdi99pd 2506 2 HTX HTX NNP cord-015365-iqdi99pd 2506 3 ergab ergab NNP cord-015365-iqdi99pd 2506 4 eine eine NNP cord-015365-iqdi99pd 2506 5 restriktive restriktive NNP cord-015365-iqdi99pd 2506 6 Ventilationsstörung Ventilationsstörung NNP cord-015365-iqdi99pd 2506 7 mit mit NNP cord-015365-iqdi99pd 2506 8 VC VC NNP cord-015365-iqdi99pd 2506 9 1,33 1,33 NNP cord-015365-iqdi99pd 2506 10 l l NN cord-015365-iqdi99pd 2506 11 ( ( -LRB- cord-015365-iqdi99pd 2506 12 37,9 37,9 CD cord-015365-iqdi99pd 2506 13 % % NN cord-015365-iqdi99pd 2506 14 ) ) -RRB- cord-015365-iqdi99pd 2506 15 , , , cord-015365-iqdi99pd 2506 16 FEV1 FEV1 NNP cord-015365-iqdi99pd 2506 17 1,29 1,29 CD cord-015365-iqdi99pd 2506 18 l l NNP cord-015365-iqdi99pd 2506 19 ( ( -LRB- cord-015365-iqdi99pd 2506 20 34,3 34,3 CD cord-015365-iqdi99pd 2506 21 % % NN cord-015365-iqdi99pd 2506 22 ) ) -RRB- cord-015365-iqdi99pd 2506 23 , , . cord-015365-iqdi99pd 2507 1 MEF50 MEF50 NNP cord-015365-iqdi99pd 2507 2 3,3 3,3 CD cord-015365-iqdi99pd 2507 3 l l NN cord-015365-iqdi99pd 2507 4 ( ( -LRB- cord-015365-iqdi99pd 2507 5 71,2 71,2 CD cord-015365-iqdi99pd 2507 6 % % NN cord-015365-iqdi99pd 2507 7 ) ) -RRB- cord-015365-iqdi99pd 2507 8 , , , cord-015365-iqdi99pd 2507 9 TLC TLC NNP cord-015365-iqdi99pd 2507 10 2,76 2,76 NNP cord-015365-iqdi99pd 2508 1 ( ( -LRB- cord-015365-iqdi99pd 2508 2 39,4 39,4 CD cord-015365-iqdi99pd 2508 3 % % NN cord-015365-iqdi99pd 2508 4 ) ) -RRB- cord-015365-iqdi99pd 2508 5 , , . cord-015365-iqdi99pd 2509 1 PaO2 PaO2 NNS cord-015365-iqdi99pd 2509 2 52,8 52,8 CD cord-015365-iqdi99pd 2509 3 % % NN cord-015365-iqdi99pd 2509 4 und und NNP cord-015365-iqdi99pd 2510 1 PaCO2 paco2 NN cord-015365-iqdi99pd 2510 2 38,7 38,7 CD cord-015365-iqdi99pd 2510 3 % % NN cord-015365-iqdi99pd 2510 4 . . . cord-015365-iqdi99pd 2511 1 Zur Zur NNP cord-015365-iqdi99pd 2511 2 Histologiegewinnung Histologiegewinnung NNP cord-015365-iqdi99pd 2511 3 wurde wurde NNP cord-015365-iqdi99pd 2511 4 nach nach NNP cord-015365-iqdi99pd 2511 5 inkonklusiver inkonklusiver NNP cord-015365-iqdi99pd 2512 1 Bronchoskopie Bronchoskopie NNP cord-015365-iqdi99pd 2512 2 eine eine NNP cord-015365-iqdi99pd 2512 3 offene offene NNP cord-015365-iqdi99pd 2512 4 Lungenbiopsie Lungenbiopsie NNP cord-015365-iqdi99pd 2512 5 durchgeführt durchgeführt NN cord-015365-iqdi99pd 2512 6 , , , cord-015365-iqdi99pd 2512 7 welche welche NNP cord-015365-iqdi99pd 2512 8 das das NNP cord-015365-iqdi99pd 2512 9 Vorliegen Vorliegen NNP cord-015365-iqdi99pd 2512 10 einer einer NNP cord-015365-iqdi99pd 2512 11 Lungenfibrose Lungenfibrose NNP cord-015365-iqdi99pd 2512 12 vom vom VBP cord-015365-iqdi99pd 2512 13 UIP UIP NNP cord-015365-iqdi99pd 2512 14 - - HYPH cord-015365-iqdi99pd 2512 15 Typ Typ NNP cord-015365-iqdi99pd 2512 16 ergab ergab NN cord-015365-iqdi99pd 2512 17 . . . cord-015365-iqdi99pd 2513 1 Die die VB cord-015365-iqdi99pd 2514 1 Kontroll Kontroll NNP cord-015365-iqdi99pd 2514 2 - - HYPH cord-015365-iqdi99pd 2514 3 Echokardiographien Echokardiographien NNP cord-015365-iqdi99pd 2514 4 zeigten zeigten NNP cord-015365-iqdi99pd 2514 5 durchwegs durchwegs NNP cord-015365-iqdi99pd 2514 6 eine eine NNP cord-015365-iqdi99pd 2514 7 gute gute NNP cord-015365-iqdi99pd 2514 8 rechtsund rechtsund NNP cord-015365-iqdi99pd 2514 9 linksventrikuläre linksventrikuläre NNP cord-015365-iqdi99pd 2514 10 Funktion Funktion NNP cord-015365-iqdi99pd 2514 11 , , , cord-015365-iqdi99pd 2514 12 allerdings allerdings NNP cord-015365-iqdi99pd 2514 13 verschlechterte verschlechterte NNP cord-015365-iqdi99pd 2514 14 sich sich NNP cord-015365-iqdi99pd 2514 15 der der NNP cord-015365-iqdi99pd 2514 16 respiratorische respiratorische NNP cord-015365-iqdi99pd 2514 17 Zustand Zustand NNP cord-015365-iqdi99pd 2514 18 des des NNP cord-015365-iqdi99pd 2514 19 Patienten Patienten NNP cord-015365-iqdi99pd 2514 20 zunehmend zunehmend NNP cord-015365-iqdi99pd 2514 21 , , , cord-015365-iqdi99pd 2514 22 sodass sodass NNP cord-015365-iqdi99pd 2514 23 er er UH cord-015365-iqdi99pd 2514 24 " " '' cord-015365-iqdi99pd 2514 25 high high JJ cord-015365-iqdi99pd 2514 26 urgent urgent JJ cord-015365-iqdi99pd 2514 27 " " '' cord-015365-iqdi99pd 2514 28 zur zur NNP cord-015365-iqdi99pd 2514 29 Lungentransplantation Lungentransplantation NNP cord-015365-iqdi99pd 2514 30 gelistet gelistet NN cord-015365-iqdi99pd 2514 31 werden werden NNP cord-015365-iqdi99pd 2514 32 musste musste NNP cord-015365-iqdi99pd 2514 33 . . . cord-015365-iqdi99pd 2515 1 Ein Ein NNP cord-015365-iqdi99pd 2515 2 größen größen NNP cord-015365-iqdi99pd 2515 3 - - HYPH cord-015365-iqdi99pd 2515 4 und und NNP cord-015365-iqdi99pd 2515 5 blutgruppenkompatibles blutgruppenkompatible NNS cord-015365-iqdi99pd 2516 1 Spenderorgan Spenderorgan NNP cord-015365-iqdi99pd 2516 2 wurde wurde NN cord-015365-iqdi99pd 2516 3 verfügbar verfügbar NNP cord-015365-iqdi99pd 2516 4 und und NNP cord-015365-iqdi99pd 2516 5 eine eine NNP cord-015365-iqdi99pd 2516 6 bilaterale bilaterale NNP cord-015365-iqdi99pd 2516 7 Lungentransplantation Lungentransplantation NNP cord-015365-iqdi99pd 2516 8 mit mit NNP cord-015365-iqdi99pd 2516 9 veno veno NNP cord-015365-iqdi99pd 2516 10 - - HYPH cord-015365-iqdi99pd 2516 11 arterieller arterieller NN cord-015365-iqdi99pd 2516 12 ECMO ECMO NNP cord-015365-iqdi99pd 2516 13 Unterstützung Unterstützung NNP cord-015365-iqdi99pd 2516 14 durchgeführt durchgeführt NN cord-015365-iqdi99pd 2516 15 . . . cord-015365-iqdi99pd 2517 1 Die die VB cord-015365-iqdi99pd 2517 2 ECMO ECMO NNP cord-015365-iqdi99pd 2517 3 konnte konnte NNP cord-015365-iqdi99pd 2517 4 am be VBP cord-015365-iqdi99pd 2517 5 Ende Ende NNP cord-015365-iqdi99pd 2517 6 der der NNP cord-015365-iqdi99pd 2517 7 Operation Operation NNP cord-015365-iqdi99pd 2517 8 bei bei NNP cord-015365-iqdi99pd 2517 9 hämodynamisch hämodynamisch NNP cord-015365-iqdi99pd 2518 1 und und NNP cord-015365-iqdi99pd 2519 1 respiratorisch respiratorisch NNP cord-015365-iqdi99pd 2519 2 stabilen stabilen NNP cord-015365-iqdi99pd 2519 3 Verhältnissen Verhältnissen NNP cord-015365-iqdi99pd 2519 4 wieder wieder NNP cord-015365-iqdi99pd 2519 5 explantiert explantiert NNP cord-015365-iqdi99pd 2520 1 werden werden NNP cord-015365-iqdi99pd 2520 2 . . . cord-015365-iqdi99pd 2521 1 Die die VB cord-015365-iqdi99pd 2521 2 Ischämiezeit Ischämiezeit NNP cord-015365-iqdi99pd 2521 3 der der NNP cord-015365-iqdi99pd 2521 4 rechten rechten NNP cord-015365-iqdi99pd 2521 5 Lunge Lunge NNP cord-015365-iqdi99pd 2521 6 betrug betrug NNP cord-015365-iqdi99pd 2521 7 340 340 CD cord-015365-iqdi99pd 2522 1 Minuten Minuten NNP cord-015365-iqdi99pd 2523 1 und und IN cord-015365-iqdi99pd 2523 2 links link VBZ cord-015365-iqdi99pd 2523 3 460 460 CD cord-015365-iqdi99pd 2523 4 Minuten Minuten NNP cord-015365-iqdi99pd 2523 5 . . . cord-015365-iqdi99pd 2524 1 Am be VBP cord-015365-iqdi99pd 2524 2 19 19 CD cord-015365-iqdi99pd 2524 3 . . . cord-015365-iqdi99pd 2525 1 postoperativen postoperativen NNP cord-015365-iqdi99pd 2525 2 Tag Tag NNP cord-015365-iqdi99pd 2525 3 konnte konnte NNP cord-015365-iqdi99pd 2525 4 der der NNP cord-015365-iqdi99pd 2526 1 Patient Patient NNP cord-015365-iqdi99pd 2526 2 auf auf NNP cord-015365-iqdi99pd 2526 3 die die VBP cord-015365-iqdi99pd 2526 4 Normalstation normalstation NN cord-015365-iqdi99pd 2526 5 verlegt verlegt NN cord-015365-iqdi99pd 2527 1 und und IN cord-015365-iqdi99pd 2527 2 nach nach NNP cord-015365-iqdi99pd 2527 3 weiteren weiteren NNP cord-015365-iqdi99pd 2528 1 23 23 CD cord-015365-iqdi99pd 2528 2 Tagen Tagen NNP cord-015365-iqdi99pd 2528 3 aus aus NNP cord-015365-iqdi99pd 2528 4 dem dem NNP cord-015365-iqdi99pd 2528 5 Krankenhaus Krankenhaus NNP cord-015365-iqdi99pd 2528 6 entlassen entlassen NNP cord-015365-iqdi99pd 2528 7 werden werden NNP cord-015365-iqdi99pd 2528 8 . . . cord-015365-iqdi99pd 2529 1 Schlussfolgerungen Schlussfolgerungen NNP cord-015365-iqdi99pd 2529 2 . . . cord-015365-iqdi99pd 2530 1 Entgegen Entgegen NNP cord-015365-iqdi99pd 2530 2 der der NNP cord-015365-iqdi99pd 2530 3 allgemeinen allgemeinen NNP cord-015365-iqdi99pd 2530 4 Erwartung Erwartung NNP cord-015365-iqdi99pd 2530 5 , , , cord-015365-iqdi99pd 2530 6 dass dass NNP cord-015365-iqdi99pd 2530 7 eine eine NNP cord-015365-iqdi99pd 2530 8 Fibrose Fibrose NNP cord-015365-iqdi99pd 2530 9 unter unter NNP cord-015365-iqdi99pd 2530 10 immunsuppressiver immunsuppressiver NNP cord-015365-iqdi99pd 2531 1 Therapie Therapie NNP cord-015365-iqdi99pd 2531 2 ein ein NNP cord-015365-iqdi99pd 2531 3 geringes geringes NNP cord-015365-iqdi99pd 2531 4 Risiko Risiko NNP cord-015365-iqdi99pd 2531 5 fü fü IN cord-015365-iqdi99pd 2531 6 r r NNP cord-015365-iqdi99pd 2531 7 Progression progression NN cord-015365-iqdi99pd 2531 8 hat hat NN cord-015365-iqdi99pd 2531 9 , , , cord-015365-iqdi99pd 2531 10 zeigte zeigte NNP cord-015365-iqdi99pd 2531 11 sich sich NNP cord-015365-iqdi99pd 2531 12 in in IN cord-015365-iqdi99pd 2531 13 diesem diesem NNP cord-015365-iqdi99pd 2531 14 Fall Fall NNP cord-015365-iqdi99pd 2531 15 eine eine NNP cord-015365-iqdi99pd 2532 1 dramatische dramatische NNP cord-015365-iqdi99pd 2532 2 Entwicklung Entwicklung NNP cord-015365-iqdi99pd 2532 3 nach nach NNP cord-015365-iqdi99pd 2532 4 der der NNP cord-015365-iqdi99pd 2532 5 Herztransplantation Herztransplantation NNP cord-015365-iqdi99pd 2532 6 . . . cord-015365-iqdi99pd 2533 1 Deshalb Deshalb NNP cord-015365-iqdi99pd 2533 2 sollte sollte NNP cord-015365-iqdi99pd 2533 3 eine eine NNP cord-015365-iqdi99pd 2534 1 Lungenfibrose lungenfibrose NN cord-015365-iqdi99pd 2534 2 vor vor NN cord-015365-iqdi99pd 2534 3 einer einer NNP cord-015365-iqdi99pd 2535 1 HTX HTX NNP cord-015365-iqdi99pd 2535 2 genau genau NNP cord-015365-iqdi99pd 2535 3 abgeklärt abgeklärt NNP cord-015365-iqdi99pd 2536 1 und und IN cord-015365-iqdi99pd 2536 2 engmaschige engmaschige NNP cord-015365-iqdi99pd 2536 3 postoperative postoperative JJ cord-015365-iqdi99pd 2536 4 Kontrollen Kontrollen NNP cord-015365-iqdi99pd 2536 5 durchgefü durchgefü NNP cord-015365-iqdi99pd 2536 6 hrt hrt NNP cord-015365-iqdi99pd 2536 7 werden werden NNP cord-015365-iqdi99pd 2536 8 . . . cord-015365-iqdi99pd 2537 1 Invasive invasive JJ cord-015365-iqdi99pd 2537 2 mycoses mycose NNS cord-015365-iqdi99pd 2537 3 after after IN cord-015365-iqdi99pd 2537 4 heart heart NN cord-015365-iqdi99pd 2537 5 transplantation transplantation NN cord-015365-iqdi99pd 2537 6 : : : cord-015365-iqdi99pd 2538 1 outcome outcome NN cord-015365-iqdi99pd 2538 2 and and CC cord-015365-iqdi99pd 2538 3 long long JJ cord-015365-iqdi99pd 2538 4 - - HYPH cord-015365-iqdi99pd 2538 5 term term NN cord-015365-iqdi99pd 2538 6 prognosis prognosis NN cord-015365-iqdi99pd 2539 1 T. T. NNP cord-015365-iqdi99pd 2539 2 Haberl Haberl NNP cord-015365-iqdi99pd 2539 3 1 1 CD cord-015365-iqdi99pd 2539 4 , , , cord-015365-iqdi99pd 2539 5 D. D. NNP cord-015365-iqdi99pd 2539 6 Hutschala Hutschala NNP cord-015365-iqdi99pd 2539 7 2 2 CD cord-015365-iqdi99pd 2539 8 , , , cord-015365-iqdi99pd 2539 9 C. C. NNP cord-015365-iqdi99pd 2539 10 Pelanek Pelanek NNP cord-015365-iqdi99pd 2539 11 1 1 CD cord-015365-iqdi99pd 2539 12 , , , cord-015365-iqdi99pd 2539 13 A. A. NNP cord-015365-iqdi99pd 2539 14 Aliabadi Aliabadi NNP cord-015365-iqdi99pd 2539 15 1 1 CD cord-015365-iqdi99pd 2539 16 , , , cord-015365-iqdi99pd 2539 17 G. G. NNP cord-015365-iqdi99pd 2539 18 Laufer Laufer NNP cord-015365-iqdi99pd 2539 19 1 1 CD cord-015365-iqdi99pd 2539 20 , , , cord-015365-iqdi99pd 2539 21 A. a. NN cord-015365-iqdi99pd 2539 22 Zuckermann Zuckermann NNP cord-015365-iqdi99pd 2540 1 1Background 1background LS cord-015365-iqdi99pd 2540 2 . . . cord-015365-iqdi99pd 2541 1 Although although IN cord-015365-iqdi99pd 2541 2 orthotopic orthotopic JJ cord-015365-iqdi99pd 2541 3 heart heart NN cord-015365-iqdi99pd 2541 4 transplantation transplantation NN cord-015365-iqdi99pd 2541 5 has have VBZ cord-015365-iqdi99pd 2541 6 become become VBN cord-015365-iqdi99pd 2541 7 a a DT cord-015365-iqdi99pd 2541 8 routine routine JJ cord-015365-iqdi99pd 2541 9 procedure procedure NN cord-015365-iqdi99pd 2541 10 in in IN cord-015365-iqdi99pd 2541 11 treatment treatment NN cord-015365-iqdi99pd 2541 12 of of IN cord-015365-iqdi99pd 2541 13 end end NN cord-015365-iqdi99pd 2541 14 - - HYPH cord-015365-iqdi99pd 2541 15 stage stage NN cord-015365-iqdi99pd 2541 16 cardiac cardiac JJ cord-015365-iqdi99pd 2541 17 failure failure NN cord-015365-iqdi99pd 2541 18 , , , cord-015365-iqdi99pd 2541 19 postoperative postoperative JJ cord-015365-iqdi99pd 2541 20 mycosal mycosal NN cord-015365-iqdi99pd 2541 21 infections infection NNS cord-015365-iqdi99pd 2541 22 are be VBP cord-015365-iqdi99pd 2541 23 still still RB cord-015365-iqdi99pd 2541 24 a a DT cord-015365-iqdi99pd 2541 25 serious serious JJ cord-015365-iqdi99pd 2541 26 risk risk NN cord-015365-iqdi99pd 2541 27 for for IN cord-015365-iqdi99pd 2541 28 the the DT cord-015365-iqdi99pd 2541 29 patients patient NNS cord-015365-iqdi99pd 2541 30 . . . cord-015365-iqdi99pd 2542 1 Objective objective NN cord-015365-iqdi99pd 2542 2 of of IN cord-015365-iqdi99pd 2542 3 the the DT cord-015365-iqdi99pd 2542 4 current current JJ cord-015365-iqdi99pd 2542 5 study study NN cord-015365-iqdi99pd 2542 6 is be VBZ cord-015365-iqdi99pd 2542 7 to to TO cord-015365-iqdi99pd 2542 8 show show VB cord-015365-iqdi99pd 2542 9 the the DT cord-015365-iqdi99pd 2542 10 influence influence NN cord-015365-iqdi99pd 2542 11 of of IN cord-015365-iqdi99pd 2542 12 various various JJ cord-015365-iqdi99pd 2542 13 parameters parameter NNS cord-015365-iqdi99pd 2542 14 on on IN cord-015365-iqdi99pd 2542 15 the the DT cord-015365-iqdi99pd 2542 16 severity severity NN cord-015365-iqdi99pd 2542 17 of of IN cord-015365-iqdi99pd 2542 18 infection infection NN cord-015365-iqdi99pd 2542 19 and and CC cord-015365-iqdi99pd 2542 20 the the DT cord-015365-iqdi99pd 2542 21 outcome outcome NN cord-015365-iqdi99pd 2542 22 for for IN cord-015365-iqdi99pd 2542 23 patients patient NNS cord-015365-iqdi99pd 2542 24 . . . cord-015365-iqdi99pd 2543 1 Methods method NNS cord-015365-iqdi99pd 2543 2 . . . cord-015365-iqdi99pd 2544 1 This this DT cord-015365-iqdi99pd 2544 2 is be VBZ cord-015365-iqdi99pd 2544 3 a a DT cord-015365-iqdi99pd 2544 4 single single JJ cord-015365-iqdi99pd 2544 5 - - HYPH cord-015365-iqdi99pd 2544 6 center center NN cord-015365-iqdi99pd 2544 7 retrospective retrospective JJ cord-015365-iqdi99pd 2544 8 study study NN cord-015365-iqdi99pd 2544 9 including include VBG cord-015365-iqdi99pd 2544 10 338 338 CD cord-015365-iqdi99pd 2544 11 patients patient NNS cord-015365-iqdi99pd 2544 12 who who WP cord-015365-iqdi99pd 2544 13 underwent undergo VBD cord-015365-iqdi99pd 2544 14 heart heart NN cord-015365-iqdi99pd 2544 15 transplantation transplantation NN cord-015365-iqdi99pd 2544 16 from from IN cord-015365-iqdi99pd 2544 17 2000 2000 CD cord-015365-iqdi99pd 2544 18 - - SYM cord-015365-iqdi99pd 2544 19 2008 2008 CD cord-015365-iqdi99pd 2544 20 at at IN cord-015365-iqdi99pd 2544 21 our -PRON- PRP$ cord-015365-iqdi99pd 2544 22 center center NN cord-015365-iqdi99pd 2544 23 in in IN cord-015365-iqdi99pd 2544 24 Vienna Vienna NNP cord-015365-iqdi99pd 2544 25 . . . cord-015365-iqdi99pd 2545 1 The the DT cord-015365-iqdi99pd 2545 2 analyzed analyze VBN cord-015365-iqdi99pd 2545 3 data datum NNS cord-015365-iqdi99pd 2545 4 were be VBD cord-015365-iqdi99pd 2545 5 collected collect VBN cord-015365-iqdi99pd 2545 6 during during IN cord-015365-iqdi99pd 2545 7 the the DT cord-015365-iqdi99pd 2545 8 post post NN cord-015365-iqdi99pd 2545 9 transplant transplant NN cord-015365-iqdi99pd 2545 10 course course NN cord-015365-iqdi99pd 2545 11 in in IN cord-015365-iqdi99pd 2545 12 the the DT cord-015365-iqdi99pd 2545 13 intensive intensive JJ cord-015365-iqdi99pd 2545 14 care care NN cord-015365-iqdi99pd 2545 15 unit unit NN cord-015365-iqdi99pd 2545 16 ( ( -LRB- cord-015365-iqdi99pd 2545 17 ICU ICU NNP cord-015365-iqdi99pd 2545 18 ) ) -RRB- cord-015365-iqdi99pd 2545 19 . . . cord-015365-iqdi99pd 2546 1 Mycoses Mycoses NNP cord-015365-iqdi99pd 2546 2 were be VBD cord-015365-iqdi99pd 2546 3 diagnosed diagnose VBN cord-015365-iqdi99pd 2546 4 by by IN cord-015365-iqdi99pd 2546 5 cultures culture NNS cord-015365-iqdi99pd 2546 6 of of IN cord-015365-iqdi99pd 2546 7 blood blood NN cord-015365-iqdi99pd 2546 8 , , , cord-015365-iqdi99pd 2546 9 bronchoalveolar bronchoalveolar NNP cord-015365-iqdi99pd 2546 10 lavages lavages NNP cord-015365-iqdi99pd 2546 11 ( ( -LRB- cord-015365-iqdi99pd 2546 12 BAL BAL NNP cord-015365-iqdi99pd 2546 13 ) ) -RRB- cord-015365-iqdi99pd 2546 14 and and CC cord-015365-iqdi99pd 2546 15 smear smear VB cord-015365-iqdi99pd 2546 16 tests test NNS cord-015365-iqdi99pd 2546 17 of of IN cord-015365-iqdi99pd 2546 18 central central JJ cord-015365-iqdi99pd 2546 19 arterial arterial JJ cord-015365-iqdi99pd 2546 20 and and CC cord-015365-iqdi99pd 2546 21 venous venous JJ cord-015365-iqdi99pd 2546 22 catheters catheter NNS cord-015365-iqdi99pd 2546 23 , , , cord-015365-iqdi99pd 2546 24 wounds wound NNS cord-015365-iqdi99pd 2546 25 and and CC cord-015365-iqdi99pd 2546 26 drainages drainage NNS cord-015365-iqdi99pd 2546 27 . . . cord-015365-iqdi99pd 2547 1 Results result NNS cord-015365-iqdi99pd 2547 2 . . . cord-015365-iqdi99pd 2548 1 Mean mean JJ cord-015365-iqdi99pd 2548 2 age age NN cord-015365-iqdi99pd 2548 3 at at IN cord-015365-iqdi99pd 2548 4 time time NN cord-015365-iqdi99pd 2548 5 of of IN cord-015365-iqdi99pd 2548 6 transplantation transplantation NN cord-015365-iqdi99pd 2548 7 was be VBD cord-015365-iqdi99pd 2548 8 49 49 CD cord-015365-iqdi99pd 2548 9 years year NNS cord-015365-iqdi99pd 2548 10 , , , cord-015365-iqdi99pd 2548 11 260 260 CD cord-015365-iqdi99pd 2548 12 patients patient NNS cord-015365-iqdi99pd 2548 13 ( ( -LRB- cord-015365-iqdi99pd 2548 14 76.9 76.9 CD cord-015365-iqdi99pd 2548 15 % % NN cord-015365-iqdi99pd 2548 16 ) ) -RRB- cord-015365-iqdi99pd 2548 17 were be VBD cord-015365-iqdi99pd 2548 18 male male JJ cord-015365-iqdi99pd 2548 19 ( ( -LRB- cord-015365-iqdi99pd 2548 20 age age NN cord-015365-iqdi99pd 2548 21 5 5 CD cord-015365-iqdi99pd 2548 22 - - SYM cord-015365-iqdi99pd 2548 23 71 71 CD cord-015365-iqdi99pd 2548 24 years year NNS cord-015365-iqdi99pd 2548 25 ) ) -RRB- cord-015365-iqdi99pd 2548 26 and and CC cord-015365-iqdi99pd 2548 27 78 78 CD cord-015365-iqdi99pd 2548 28 patients patient NNS cord-015365-iqdi99pd 2548 29 ( ( -LRB- cord-015365-iqdi99pd 2548 30 23.1 23.1 CD cord-015365-iqdi99pd 2548 31 % % NN cord-015365-iqdi99pd 2548 32 ) ) -RRB- cord-015365-iqdi99pd 2548 33 were be VBD cord-015365-iqdi99pd 2548 34 female female JJ cord-015365-iqdi99pd 2548 35 ( ( -LRB- cord-015365-iqdi99pd 2548 36 age age NN cord-015365-iqdi99pd 2548 37 3 3 CD cord-015365-iqdi99pd 2548 38 weeks-76 weeks-76 NNS cord-015365-iqdi99pd 2548 39 years year NNS cord-015365-iqdi99pd 2548 40 ) ) -RRB- cord-015365-iqdi99pd 2548 41 . . . cord-015365-iqdi99pd 2549 1 90 90 CD cord-015365-iqdi99pd 2549 2 patients patient NNS cord-015365-iqdi99pd 2549 3 ( ( -LRB- cord-015365-iqdi99pd 2549 4 34 34 CD cord-015365-iqdi99pd 2549 5 % % NN cord-015365-iqdi99pd 2549 6 ) ) -RRB- cord-015365-iqdi99pd 2549 7 acquired acquire VBD cord-015365-iqdi99pd 2549 8 an an DT cord-015365-iqdi99pd 2549 9 invasive invasive JJ cord-015365-iqdi99pd 2549 10 mycosal mycosal NN cord-015365-iqdi99pd 2549 11 infection infection NN cord-015365-iqdi99pd 2549 12 with with IN cord-015365-iqdi99pd 2549 13 candida candida NN cord-015365-iqdi99pd 2549 14 species specie NNS cord-015365-iqdi99pd 2549 15 ( ( -LRB- cord-015365-iqdi99pd 2549 16 94.3 94.3 CD cord-015365-iqdi99pd 2549 17 % % NN cord-015365-iqdi99pd 2549 18 ) ) -RRB- cord-015365-iqdi99pd 2549 19 , , , cord-015365-iqdi99pd 2549 20 aspergillus aspergillus NN cord-015365-iqdi99pd 2549 21 ( ( -LRB- cord-015365-iqdi99pd 2549 22 3.8 3.8 CD cord-015365-iqdi99pd 2549 23 % % NN cord-015365-iqdi99pd 2549 24 ) ) -RRB- cord-015365-iqdi99pd 2549 25 and and CC cord-015365-iqdi99pd 2549 26 pneumocystis pneumocystis NNP cord-015365-iqdi99pd 2549 27 carinii carinii FW cord-015365-iqdi99pd 2549 28 ( ( -LRB- cord-015365-iqdi99pd 2549 29 1.9 1.9 CD cord-015365-iqdi99pd 2549 30 % % NN cord-015365-iqdi99pd 2549 31 ) ) -RRB- cord-015365-iqdi99pd 2549 32 . . . cord-015365-iqdi99pd 2550 1 Diagnosis diagnosis NN cord-015365-iqdi99pd 2550 2 was be VBD cord-015365-iqdi99pd 2550 3 performed perform VBN cord-015365-iqdi99pd 2550 4 in in IN cord-015365-iqdi99pd 2550 5 24.1 24.1 CD cord-015365-iqdi99pd 2550 6 % % NN cord-015365-iqdi99pd 2550 7 by by IN cord-015365-iqdi99pd 2550 8 cultures culture NNS cord-015365-iqdi99pd 2550 9 of of IN cord-015365-iqdi99pd 2550 10 blood blood NN cord-015365-iqdi99pd 2550 11 , , , cord-015365-iqdi99pd 2550 12 in in IN cord-015365-iqdi99pd 2550 13 23.5 23.5 CD cord-015365-iqdi99pd 2550 14 % % NN cord-015365-iqdi99pd 2550 15 by by IN cord-015365-iqdi99pd 2550 16 BAL BAL NNP cord-015365-iqdi99pd 2550 17 , , , cord-015365-iqdi99pd 2550 18 18.8 18.8 CD cord-015365-iqdi99pd 2550 19 % % NN cord-015365-iqdi99pd 2550 20 by by IN cord-015365-iqdi99pd 2550 21 smear smear NN cord-015365-iqdi99pd 2550 22 tests test NNS cord-015365-iqdi99pd 2550 23 of of IN cord-015365-iqdi99pd 2550 24 vena vena NNP cord-015365-iqdi99pd 2550 25 - - HYPH cord-015365-iqdi99pd 2550 26 cava cava NNP cord-015365-iqdi99pd 2550 27 catheters catheter NNS cord-015365-iqdi99pd 2550 28 and and CC cord-015365-iqdi99pd 2550 29 in in IN cord-015365-iqdi99pd 2550 30 11.1 11.1 CD cord-015365-iqdi99pd 2550 31 % % NN cord-015365-iqdi99pd 2550 32 from from IN cord-015365-iqdi99pd 2550 33 pulmonal pulmonal JJ cord-015365-iqdi99pd 2550 34 artery artery NN cord-015365-iqdi99pd 2550 35 catheters catheter NNS cord-015365-iqdi99pd 2550 36 . . . cord-015365-iqdi99pd 2551 1 In in IN cord-015365-iqdi99pd 2551 2 77.6 77.6 CD cord-015365-iqdi99pd 2551 3 % % NN cord-015365-iqdi99pd 2551 4 treatment treatment NN cord-015365-iqdi99pd 2551 5 with with IN cord-015365-iqdi99pd 2551 6 a a DT cord-015365-iqdi99pd 2551 7 single single JJ cord-015365-iqdi99pd 2551 8 antimycosal antimycosal NN cord-015365-iqdi99pd 2551 9 therapy therapy NN cord-015365-iqdi99pd 2551 10 was be VBD cord-015365-iqdi99pd 2551 11 sufficient sufficient JJ cord-015365-iqdi99pd 2551 12 . . . cord-015365-iqdi99pd 2552 1 20.9 20.9 CD cord-015365-iqdi99pd 2552 2 % % NN cord-015365-iqdi99pd 2552 3 of of IN cord-015365-iqdi99pd 2552 4 patients patient NNS cord-015365-iqdi99pd 2552 5 were be VBD cord-015365-iqdi99pd 2552 6 in in IN cord-015365-iqdi99pd 2552 7 need need NN cord-015365-iqdi99pd 2552 8 of of IN cord-015365-iqdi99pd 2552 9 a a DT cord-015365-iqdi99pd 2552 10 double double JJ cord-015365-iqdi99pd 2552 11 - - HYPH cord-015365-iqdi99pd 2552 12 drug drug NN cord-015365-iqdi99pd 2552 13 therapy therapy NN cord-015365-iqdi99pd 2552 14 and and CC cord-015365-iqdi99pd 2552 15 1.5 1.5 CD cord-015365-iqdi99pd 2552 16 % % NN cord-015365-iqdi99pd 2552 17 needed need VBD cord-015365-iqdi99pd 2552 18 a a DT cord-015365-iqdi99pd 2552 19 triple triple JJ cord-015365-iqdi99pd 2552 20 - - HYPH cord-015365-iqdi99pd 2552 21 drug drug NN cord-015365-iqdi99pd 2552 22 - - HYPH cord-015365-iqdi99pd 2552 23 therapy therapy NN cord-015365-iqdi99pd 2552 24 . . . cord-015365-iqdi99pd 2553 1 Patients patient NNS cord-015365-iqdi99pd 2553 2 with with IN cord-015365-iqdi99pd 2553 3 mycosal mycosal NN cord-015365-iqdi99pd 2553 4 infection infection NN cord-015365-iqdi99pd 2553 5 had have VBD cord-015365-iqdi99pd 2553 6 an an DT cord-015365-iqdi99pd 2553 7 median median NN cord-015365-iqdi99pd 2553 8 stay stay NN cord-015365-iqdi99pd 2553 9 in in IN cord-015365-iqdi99pd 2553 10 the the DT cord-015365-iqdi99pd 2553 11 ICU ICU NNP cord-015365-iqdi99pd 2553 12 of of IN cord-015365-iqdi99pd 2553 13 16 16 CD cord-015365-iqdi99pd 2553 14 days day NNS cord-015365-iqdi99pd 2554 1 ( ( -LRB- cord-015365-iqdi99pd 2554 2 1st 1st NNP cord-015365-iqdi99pd 2554 3 Quartile Quartile NNP cord-015365-iqdi99pd 2554 4 : : : cord-015365-iqdi99pd 2554 5 7.25 7.25 CD cord-015365-iqdi99pd 2554 6 , , , cord-015365-iqdi99pd 2554 7 3rd 3rd NNP cord-015365-iqdi99pd 2554 8 Quartile Quartile NNP cord-015365-iqdi99pd 2554 9 : : : cord-015365-iqdi99pd 2554 10 24.75 24.75 CD cord-015365-iqdi99pd 2554 11 ) ) -RRB- cord-015365-iqdi99pd 2554 12 with with IN cord-015365-iqdi99pd 2554 13 a a DT cord-015365-iqdi99pd 2554 14 median median NN cord-015365-iqdi99pd 2554 15 of of IN cord-015365-iqdi99pd 2554 16 4.5 4.5 CD cord-015365-iqdi99pd 2554 17 ( ( -LRB- cord-015365-iqdi99pd 2554 18 Q1 q1 NN cord-015365-iqdi99pd 2554 19 : : : cord-015365-iqdi99pd 2554 20 0 0 NFP cord-015365-iqdi99pd 2554 21 , , , cord-015365-iqdi99pd 2554 22 Q3 q3 NN cord-015365-iqdi99pd 2554 23 : : : cord-015365-iqdi99pd 2554 24 7 7 CD cord-015365-iqdi99pd 2554 25 ) ) -RRB- cord-015365-iqdi99pd 2554 26 respirator respirator NN cord-015365-iqdi99pd 2554 27 - - HYPH cord-015365-iqdi99pd 2554 28 days day NNS cord-015365-iqdi99pd 2554 29 compared compare VBN cord-015365-iqdi99pd 2554 30 with with IN cord-015365-iqdi99pd 2554 31 patient patient NN cord-015365-iqdi99pd 2554 32 without without IN cord-015365-iqdi99pd 2554 33 infection infection NN cord-015365-iqdi99pd 2554 34 who who WP cord-015365-iqdi99pd 2554 35 had have VBD cord-015365-iqdi99pd 2554 36 median median JJ cord-015365-iqdi99pd 2554 37 9 9 CD cord-015365-iqdi99pd 2554 38 ( ( -LRB- cord-015365-iqdi99pd 2554 39 Q1 Q1 NNP cord-015365-iqdi99pd 2554 40 : : : cord-015365-iqdi99pd 2554 41 4 4 CD cord-015365-iqdi99pd 2554 42 , , , cord-015365-iqdi99pd 2554 43 Q3 Q3 NNP cord-015365-iqdi99pd 2554 44 : : : cord-015365-iqdi99pd 2554 45 16 16 CD cord-015365-iqdi99pd 2554 46 ) ) -RRB- cord-015365-iqdi99pd 2554 47 days day NNS cord-015365-iqdi99pd 2554 48 in in IN cord-015365-iqdi99pd 2554 49 ICU ICU NNP cord-015365-iqdi99pd 2554 50 with with IN cord-015365-iqdi99pd 2554 51 1 1 CD cord-015365-iqdi99pd 2555 1 ( ( -LRB- cord-015365-iqdi99pd 2555 2 Q1 Q1 NNP cord-015365-iqdi99pd 2555 3 : : : cord-015365-iqdi99pd 2555 4 0 0 NFP cord-015365-iqdi99pd 2555 5 , , , cord-015365-iqdi99pd 2555 6 Q3 q3 NN cord-015365-iqdi99pd 2555 7 : : : cord-015365-iqdi99pd 2555 8 2 2 LS cord-015365-iqdi99pd 2555 9 ) ) -RRB- cord-015365-iqdi99pd 2555 10 respirator respirator NN cord-015365-iqdi99pd 2555 11 - - HYPH cord-015365-iqdi99pd 2555 12 days day NNS cord-015365-iqdi99pd 2555 13 . . . cord-015365-iqdi99pd 2556 1 100 100 CD cord-015365-iqdi99pd 2556 2 % % NN cord-015365-iqdi99pd 2556 3 of of IN cord-015365-iqdi99pd 2556 4 the the DT cord-015365-iqdi99pd 2556 5 patients patient NNS cord-015365-iqdi99pd 2556 6 with with IN cord-015365-iqdi99pd 2556 7 mycosis mycosi NNS cord-015365-iqdi99pd 2556 8 compared compare VBN cord-015365-iqdi99pd 2556 9 to to IN cord-015365-iqdi99pd 2556 10 49 49 CD cord-015365-iqdi99pd 2556 11 % % NN cord-015365-iqdi99pd 2556 12 of of IN cord-015365-iqdi99pd 2556 13 the the DT cord-015365-iqdi99pd 2556 14 patients patient NNS cord-015365-iqdi99pd 2556 15 without without IN cord-015365-iqdi99pd 2556 16 mycosis mycosis NNP cord-015365-iqdi99pd 2556 17 developed develop VBD cord-015365-iqdi99pd 2556 18 or or CC cord-015365-iqdi99pd 2556 19 already already RB cord-015365-iqdi99pd 2556 20 had have VBN cord-015365-iqdi99pd 2556 21 bacterial bacterial JJ cord-015365-iqdi99pd 2556 22 co co NN cord-015365-iqdi99pd 2556 23 - - NN cord-015365-iqdi99pd 2556 24 infection infection NN cord-015365-iqdi99pd 2557 1 ( ( -LRB- cord-015365-iqdi99pd 2557 2 p p NN cord-015365-iqdi99pd 2557 3 < < XX cord-015365-iqdi99pd 2557 4 0.001 0.001 CD cord-015365-iqdi99pd 2557 5 ) ) -RRB- cord-015365-iqdi99pd 2557 6 . . . cord-015365-iqdi99pd 2558 1 The the DT cord-015365-iqdi99pd 2558 2 1-year 1-year CD cord-015365-iqdi99pd 2558 3 survival survival NN cord-015365-iqdi99pd 2558 4 of of IN cord-015365-iqdi99pd 2558 5 patients patient NNS cord-015365-iqdi99pd 2558 6 with with IN cord-015365-iqdi99pd 2558 7 mycosis mycosis NNP cord-015365-iqdi99pd 2558 8 was be VBD cord-015365-iqdi99pd 2558 9 63.3 63.3 CD cord-015365-iqdi99pd 2558 10 % % NN cord-015365-iqdi99pd 2558 11 compared compare VBN cord-015365-iqdi99pd 2558 12 to to IN cord-015365-iqdi99pd 2558 13 248 248 CD cord-015365-iqdi99pd 2558 14 patients patient NNS cord-015365-iqdi99pd 2558 15 without without IN cord-015365-iqdi99pd 2558 16 infection infection NN cord-015365-iqdi99pd 2558 17 where where WRB cord-015365-iqdi99pd 2558 18 1-year 1-year CD cord-015365-iqdi99pd 2558 19 survival survival NN cord-015365-iqdi99pd 2558 20 was be VBD cord-015365-iqdi99pd 2558 21 83.3 83.3 CD cord-015365-iqdi99pd 2558 22 % % NN cord-015365-iqdi99pd 2558 23 ( ( -LRB- cord-015365-iqdi99pd 2558 24 p p NN cord-015365-iqdi99pd 2558 25 < < XX cord-015365-iqdi99pd 2558 26 0.001 0.001 CD cord-015365-iqdi99pd 2558 27 ) ) -RRB- cord-015365-iqdi99pd 2558 28 . . . cord-015365-iqdi99pd 2559 1 Average average JJ cord-015365-iqdi99pd 2559 2 time time NN cord-015365-iqdi99pd 2559 3 to to IN cord-015365-iqdi99pd 2559 4 first first JJ cord-015365-iqdi99pd 2559 5 fungal fungal JJ cord-015365-iqdi99pd 2559 6 infection infection NN cord-015365-iqdi99pd 2559 7 was be VBD cord-015365-iqdi99pd 2559 8 7.6 7.6 CD cord-015365-iqdi99pd 2559 9 AE AE NNP cord-015365-iqdi99pd 2559 10 5.3 5.3 CD cord-015365-iqdi99pd 2559 11 days day NNS cord-015365-iqdi99pd 2559 12 . . . cord-015365-iqdi99pd 2560 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2560 2 . . . cord-015365-iqdi99pd 2561 1 Invasive invasive JJ cord-015365-iqdi99pd 2561 2 mycosal mycosal NN cord-015365-iqdi99pd 2561 3 infection infection NN cord-015365-iqdi99pd 2561 4 acquired acquire VBN cord-015365-iqdi99pd 2561 5 by by IN cord-015365-iqdi99pd 2561 6 immune immune JJ cord-015365-iqdi99pd 2561 7 suppressed suppress VBN cord-015365-iqdi99pd 2561 8 patients patient NNS cord-015365-iqdi99pd 2561 9 after after IN cord-015365-iqdi99pd 2561 10 heart heart NN cord-015365-iqdi99pd 2561 11 transplantation transplantation NN cord-015365-iqdi99pd 2561 12 is be VBZ cord-015365-iqdi99pd 2561 13 associated associate VBN cord-015365-iqdi99pd 2561 14 with with IN cord-015365-iqdi99pd 2561 15 prolonged prolonged JJ cord-015365-iqdi99pd 2561 16 time time NN cord-015365-iqdi99pd 2561 17 of of IN cord-015365-iqdi99pd 2561 18 stay stay NN cord-015365-iqdi99pd 2561 19 on on IN cord-015365-iqdi99pd 2561 20 the the DT cord-015365-iqdi99pd 2561 21 ICU ICU NNP cord-015365-iqdi99pd 2561 22 as as RB cord-015365-iqdi99pd 2561 23 well well RB cord-015365-iqdi99pd 2561 24 as as IN cord-015365-iqdi99pd 2561 25 higher high JJR cord-015365-iqdi99pd 2561 26 rates rate NNS cord-015365-iqdi99pd 2561 27 of of IN cord-015365-iqdi99pd 2561 28 co co NNS cord-015365-iqdi99pd 2561 29 - - NNS cord-015365-iqdi99pd 2561 30 infections infection NNS cord-015365-iqdi99pd 2561 31 and and CC cord-015365-iqdi99pd 2561 32 a a DT cord-015365-iqdi99pd 2561 33 significant significant JJ cord-015365-iqdi99pd 2561 34 increase increase NN cord-015365-iqdi99pd 2561 35 of of IN cord-015365-iqdi99pd 2561 36 mortality mortality NN cord-015365-iqdi99pd 2561 37 post post NN cord-015365-iqdi99pd 2561 38 transplant transplant NN cord-015365-iqdi99pd 2561 39 . . . cord-015365-iqdi99pd 2562 1 Background background NN cord-015365-iqdi99pd 2562 2 . . . cord-015365-iqdi99pd 2563 1 Xenotransplantation xenotransplantation NN cord-015365-iqdi99pd 2563 2 is be VBZ cord-015365-iqdi99pd 2563 3 a a DT cord-015365-iqdi99pd 2563 4 potential potential JJ cord-015365-iqdi99pd 2563 5 strategy strategy NN cord-015365-iqdi99pd 2563 6 to to TO cord-015365-iqdi99pd 2563 7 overcome overcome VB cord-015365-iqdi99pd 2563 8 the the DT cord-015365-iqdi99pd 2563 9 shortage shortage NN cord-015365-iqdi99pd 2563 10 of of IN cord-015365-iqdi99pd 2563 11 human human JJ cord-015365-iqdi99pd 2563 12 donor donor NN cord-015365-iqdi99pd 2563 13 organs organ NNS cord-015365-iqdi99pd 2563 14 . . . cord-015365-iqdi99pd 2564 1 Since since IN cord-015365-iqdi99pd 2564 2 this this DT cord-015365-iqdi99pd 2564 3 technique technique NN cord-015365-iqdi99pd 2564 4 has have VBZ cord-015365-iqdi99pd 2564 5 a a DT cord-015365-iqdi99pd 2564 6 major major JJ cord-015365-iqdi99pd 2564 7 medical medical JJ cord-015365-iqdi99pd 2564 8 and and CC cord-015365-iqdi99pd 2564 9 psychological psychological JJ cord-015365-iqdi99pd 2564 10 impact impact NN cord-015365-iqdi99pd 2564 11 on on IN cord-015365-iqdi99pd 2564 12 patients patient NNS cord-015365-iqdi99pd 2564 13 and and CC cord-015365-iqdi99pd 2564 14 their -PRON- PRP$ cord-015365-iqdi99pd 2564 15 family family NN cord-015365-iqdi99pd 2564 16 and and CC cord-015365-iqdi99pd 2564 17 friends friend NNS cord-015365-iqdi99pd 2564 18 , , , cord-015365-iqdi99pd 2564 19 the the DT cord-015365-iqdi99pd 2564 20 attitude attitude NN cord-015365-iqdi99pd 2564 21 of of IN cord-015365-iqdi99pd 2564 22 patients patient NNS cord-015365-iqdi99pd 2564 23 currently currently RB cord-015365-iqdi99pd 2564 24 waiting wait VBG cord-015365-iqdi99pd 2564 25 for for IN cord-015365-iqdi99pd 2564 26 organ organ NN cord-015365-iqdi99pd 2564 27 transplantation transplantation NN cord-015365-iqdi99pd 2564 28 is be VBZ cord-015365-iqdi99pd 2564 29 important important JJ cord-015365-iqdi99pd 2564 30 . . . cord-015365-iqdi99pd 2565 1 Medhods Medhods NNP cord-015365-iqdi99pd 2565 2 . . . cord-015365-iqdi99pd 2566 1 Therefore therefore RB cord-015365-iqdi99pd 2566 2 we -PRON- PRP cord-015365-iqdi99pd 2566 3 conducted conduct VBD cord-015365-iqdi99pd 2566 4 a a DT cord-015365-iqdi99pd 2566 5 survey survey NN cord-015365-iqdi99pd 2566 6 on on IN cord-015365-iqdi99pd 2566 7 the the DT cord-015365-iqdi99pd 2566 8 attitude attitude NN cord-015365-iqdi99pd 2566 9 towards towards IN cord-015365-iqdi99pd 2566 10 xenotransplantation xenotransplantation NN cord-015365-iqdi99pd 2566 11 of of IN cord-015365-iqdi99pd 2566 12 patients patient NNS cord-015365-iqdi99pd 2566 13 on on IN cord-015365-iqdi99pd 2566 14 the the DT cord-015365-iqdi99pd 2566 15 waiting waiting NN cord-015365-iqdi99pd 2566 16 list list NN cord-015365-iqdi99pd 2566 17 and and CC cord-015365-iqdi99pd 2566 18 already already RB cord-015365-iqdi99pd 2566 19 transplanted transplant VBN cord-015365-iqdi99pd 2566 20 patients patient NNS cord-015365-iqdi99pd 2566 21 . . . cord-015365-iqdi99pd 2567 1 Patients patient NNS cord-015365-iqdi99pd 2567 2 received receive VBD cord-015365-iqdi99pd 2567 3 detailed detailed JJ cord-015365-iqdi99pd 2567 4 information information NN cord-015365-iqdi99pd 2567 5 before before IN cord-015365-iqdi99pd 2567 6 being be VBG cord-015365-iqdi99pd 2567 7 asked ask VBN cord-015365-iqdi99pd 2567 8 to to TO cord-015365-iqdi99pd 2567 9 fill fill VB cord-015365-iqdi99pd 2567 10 in in RP cord-015365-iqdi99pd 2567 11 the the DT cord-015365-iqdi99pd 2567 12 questionnaire questionnaire NN cord-015365-iqdi99pd 2567 13 . . . cord-015365-iqdi99pd 2568 1 Results result NNS cord-015365-iqdi99pd 2568 2 . . . cord-015365-iqdi99pd 2569 1 We -PRON- PRP cord-015365-iqdi99pd 2569 2 found find VBD cord-015365-iqdi99pd 2569 3 that that IN cord-015365-iqdi99pd 2569 4 65 65 CD cord-015365-iqdi99pd 2569 5 % % NN cord-015365-iqdi99pd 2569 6 would would MD cord-015365-iqdi99pd 2569 7 accept accept VB cord-015365-iqdi99pd 2569 8 xenotransplantation xenotransplantation NN cord-015365-iqdi99pd 2569 9 , , , cord-015365-iqdi99pd 2569 10 irrespective irrespective RB cord-015365-iqdi99pd 2569 11 of of IN cord-015365-iqdi99pd 2569 12 gender gender NN cord-015365-iqdi99pd 2569 13 , , , cord-015365-iqdi99pd 2569 14 education education NN cord-015365-iqdi99pd 2569 15 level level NN cord-015365-iqdi99pd 2569 16 or or CC cord-015365-iqdi99pd 2569 17 if if IN cord-015365-iqdi99pd 2569 18 the the DT cord-015365-iqdi99pd 2569 19 patients patient NNS cord-015365-iqdi99pd 2569 20 were be VBD cord-015365-iqdi99pd 2569 21 on on IN cord-015365-iqdi99pd 2569 22 the the DT cord-015365-iqdi99pd 2569 23 waiting waiting NN cord-015365-iqdi99pd 2569 24 list list NN cord-015365-iqdi99pd 2569 25 or or CC cord-015365-iqdi99pd 2569 26 already already RB cord-015365-iqdi99pd 2569 27 transplanted transplant VBN cord-015365-iqdi99pd 2569 28 . . . cord-015365-iqdi99pd 2570 1 The the DT cord-015365-iqdi99pd 2570 2 most most RBS cord-015365-iqdi99pd 2570 3 common common JJ cord-015365-iqdi99pd 2570 4 concern concern NN cord-015365-iqdi99pd 2570 5 was be VBD cord-015365-iqdi99pd 2570 6 transmission transmission NN cord-015365-iqdi99pd 2570 7 of of IN cord-015365-iqdi99pd 2570 8 diseases disease NNS cord-015365-iqdi99pd 2570 9 or or CC cord-015365-iqdi99pd 2570 10 genetic genetic JJ cord-015365-iqdi99pd 2570 11 material material NN cord-015365-iqdi99pd 2570 12 , , , cord-015365-iqdi99pd 2570 13 followed follow VBN cord-015365-iqdi99pd 2570 14 by by IN cord-015365-iqdi99pd 2570 15 psychological psychological JJ cord-015365-iqdi99pd 2570 16 concerns concern NNS cord-015365-iqdi99pd 2570 17 and and CC cord-015365-iqdi99pd 2570 18 ethical ethical JJ cord-015365-iqdi99pd 2570 19 issues issue NNS cord-015365-iqdi99pd 2570 20 . . . cord-015365-iqdi99pd 2571 1 More More JJR cord-015365-iqdi99pd 2571 2 patients patient NNS cord-015365-iqdi99pd 2571 3 had have VBD cord-015365-iqdi99pd 2571 4 a a DT cord-015365-iqdi99pd 2571 5 positive positive JJ cord-015365-iqdi99pd 2571 6 attitude attitude NN cord-015365-iqdi99pd 2571 7 towards towards IN cord-015365-iqdi99pd 2571 8 accepting accept VBG cord-015365-iqdi99pd 2571 9 cell cell NN cord-015365-iqdi99pd 2571 10 or or CC cord-015365-iqdi99pd 2571 11 tissue tissue NN cord-015365-iqdi99pd 2571 12 transplantation transplantation NN cord-015365-iqdi99pd 2571 13 as as IN cord-015365-iqdi99pd 2571 14 compared compare VBN cord-015365-iqdi99pd 2571 15 to to IN cord-015365-iqdi99pd 2571 16 whole whole JJ cord-015365-iqdi99pd 2571 17 organs organ NNS cord-015365-iqdi99pd 2571 18 . . . cord-015365-iqdi99pd 2572 1 Pig pig NN cord-015365-iqdi99pd 2572 2 pancreas pancrea VBZ cord-015365-iqdi99pd 2572 3 islet islet NN cord-015365-iqdi99pd 2572 4 cell cell NN cord-015365-iqdi99pd 2572 5 transplantation transplantation NN cord-015365-iqdi99pd 2572 6 is be VBZ cord-015365-iqdi99pd 2572 7 generally generally RB cord-015365-iqdi99pd 2572 8 well well RB cord-015365-iqdi99pd 2572 9 accepted accept VBN cord-015365-iqdi99pd 2572 10 , , , cord-015365-iqdi99pd 2572 11 patients patient NNS cord-015365-iqdi99pd 2572 12 with with IN cord-015365-iqdi99pd 2572 13 diabetes diabetes NN cord-015365-iqdi99pd 2572 14 mellitus mellitus NN cord-015365-iqdi99pd 2572 15 show show VBP cord-015365-iqdi99pd 2572 16 even even RB cord-015365-iqdi99pd 2572 17 higher high JJR cord-015365-iqdi99pd 2572 18 acceptance acceptance NN cord-015365-iqdi99pd 2572 19 rates rate NNS cord-015365-iqdi99pd 2572 20 than than IN cord-015365-iqdi99pd 2572 21 patients patient NNS cord-015365-iqdi99pd 2572 22 without without IN cord-015365-iqdi99pd 2572 23 diabetes diabetes NN cord-015365-iqdi99pd 2572 24 . . . cord-015365-iqdi99pd 2573 1 Conclusions conclusion NNS cord-015365-iqdi99pd 2573 2 . . . cord-015365-iqdi99pd 2574 1 Xenotransplantation Xenotransplantation NNP cord-015365-iqdi99pd 2574 2 seems seem VBZ cord-015365-iqdi99pd 2574 3 to to TO cord-015365-iqdi99pd 2574 4 be be VB cord-015365-iqdi99pd 2574 5 well well RB cord-015365-iqdi99pd 2574 6 accepted accept VBN cord-015365-iqdi99pd 2574 7 in in IN cord-015365-iqdi99pd 2574 8 patients patient NNS cord-015365-iqdi99pd 2574 9 who who WP cord-015365-iqdi99pd 2574 10 are be VBP cord-015365-iqdi99pd 2574 11 potential potential JJ cord-015365-iqdi99pd 2574 12 future future JJ cord-015365-iqdi99pd 2574 13 candidates candidate NNS cord-015365-iqdi99pd 2574 14 for for IN cord-015365-iqdi99pd 2574 15 organ organ NN cord-015365-iqdi99pd 2574 16 transplantation transplantation NN cord-015365-iqdi99pd 2574 17 . . . cord-015365-iqdi99pd 2575 1 Informing inform VBG cord-015365-iqdi99pd 2575 2 patients patient NNS cord-015365-iqdi99pd 2575 3 about about IN cord-015365-iqdi99pd 2575 4 the the DT cord-015365-iqdi99pd 2575 5 current current JJ cord-015365-iqdi99pd 2575 6 status status NN cord-015365-iqdi99pd 2575 7 of of IN cord-015365-iqdi99pd 2575 8 research research NN cord-015365-iqdi99pd 2575 9 tended tend VBD cord-015365-iqdi99pd 2575 10 to to TO cord-015365-iqdi99pd 2575 11 decrease decrease VB cord-015365-iqdi99pd 2575 12 acceptance acceptance NN cord-015365-iqdi99pd 2575 13 rates rate NNS cord-015365-iqdi99pd 2575 14 slightly slightly RB cord-015365-iqdi99pd 2575 15 . . .