Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 97 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 36546 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 44 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 98 CMV 28 patient 25 infection 19 cell 17 HSCT 15 EBV 14 HIV 12 GVHD 12 CD4 10 transplant 10 HLA 8 transplantation 8 die 8 Patienten 8 PCR 8 CD8 7 und 7 dna 7 der 7 HCT 7 AML 6 result 6 recipient 6 day 6 Therapie 6 RNA 6 RIC 6 NRM 6 HCV 6 ATG 5 von 5 disease 5 HSV 5 CD34 5 AIDS 4 virus 4 mit 4 lung 4 graft 4 figure 4 University 4 TBI 4 Infektion 4 IVIG 4 ICU 4 EBMT 4 ASCT 3 werden 3 sind 3 sequence Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 24192 patient 22598 % 18814 cell 8470 infection 6669 disease 5778 day 5377 transplant 5275 transplantation 5156 donor 4833 treatment 4747 study 4486 year 4317 group 3971 result 3838 virus 3832 risk 3717 t 3602 recipient 3585 therapy 3444 month 3117 response 3091 time 3036 p 3027 case 3010 stem 2909 graft 2783 survival 2722 age 2715 method 2681 analysis 2643 level 2602 blood 2209 dose 2137 outcome 2132 factor 2116 antibody 2070 rate 2068 datum 2026 effect 2016 conclusion 2010 diagnosis 1951 regimen 1931 expression 1892 b 1882 conditioning 1878 incidence 1843 number 1822 mortality 1821 child 1815 n Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 4633 CMV 4309 HSCT 3055 T 2778 der 2391 GVHD 1696 mg 1536 HLA 1471 von 1431 SCT 1430 al 1347 CD4 1342 de 1280 HIV 1260 mit 1159 PCR 1140 bei 1125 OS 1122 . 1108 et 1061 EBV 1030 AML 1029 eine 1010 B 971 und 949 CD8 932 werden 896 GvHD 880 CD34 845 ATG 825 C 814 NK 768 CI 759 zu 751 II 747 einer 746 kg 710 IV 703 ASCT 686 sind 684 la 670 HCT 662 oder 654 G 599 IFN 588 durch 576 University 573 RIC 562 CR 542 A 531 ist Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 6817 we 2260 it 1556 i 762 they 616 he 574 them 436 she 130 us 69 one 66 itself 32 themselves 18 you 13 him 12 her 7 mg 6 bohv-4 5 me 5 itma 3 herself 2 ourselves 2 ours 2 n40np 2 interleukin-15 2 igmcic 2 igg4 2 himself 2 esat-6 2 e2f2-/-mice 2 e.g.• 2 crx-527 1 ≥65 1 αat 1 yourself 1 wel 1 u 1 tdcs 1 sdc‐sign 1 s382 1 rab3b 1 pt#3 1 prets 1 pi3kg 1 phosphonylmethoxy)propyl]cytosine 1 pep005 1 p078 1 p029 1 mtecs 1 immunosuppression-0,26 1 il12rb1 1 il-7ra Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 66930 be 11780 have 5139 use 3735 die 3566 receive 3414 show 3210 include 3139 associate 2600 compare 2582 follow 2448 increase 2091 develop 1936 treat 1921 perform 1889 do 1848 report 1779 occur 1714 base 1663 reduce 1588 observe 1541 find 1487 relate 1469 identify 1434 undergo 1313 cause 1298 induce 1273 present 1258 suggest 1229 remain 1184 evaluate 1149 analyze 1122 require 1115 demonstrate 1112 consider 1077 result 1052 lead 1020 give 1012 match 980 detect 957 improve 916 diagnose 911 determine 907 see 872 describe 865 provide 864 express 858 decrease 832 assess 828 achieve 815 indicate Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 5934 - 5238 not 4937 high 3059 median 2824 clinical 2740 acute 2640 immune 2640 also 2607 low 2413 other 2291 more 2220 well 2135 viral 2036 severe 1988 first 1984 respectively 1979 specific 1974 only 1926 however 1924 significant 1832 non 1819 most 1807 human 1758 chronic 1729 early 1628 significantly 1548 positive 1477 anti 1454 hematopoietic 1434 primary 1433 renal 1407 such 1387 different 1377 overall 1290 long 1221 as 1216 respiratory 1146 negative 1136 peripheral 1121 common 1079 post 1058 unrelated 1046 further 1026 normal 974 single 959 important 934 autologous 913 second 882 old 875 free Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 462 most 285 least 246 Most 201 high 200 good 66 great 64 large 57 low 17 strong 16 bad 15 early 15 common 14 near 14 late 12 long 9 young 6 simple 5 old 5 close 4 poor 4 p=0.016 4 fast 4 -t 3 small 3 short 2 sick 2 new 2 fit 2 big 2 B27 1 αGal 1 slow 1 severe 1 rare 1 pT7JE5 1 ofT 1 myeloperoxidase/ 1 mother(N=31 1 ll.llA 1 few 1 deep 1 day15 1 clear 1 brief 1 age(≦60 1 VEGFR-1 1 PRA>10 1 P=0.0002).Our 1 HFOVm 1 HBcAb Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 1357 most 201 least 37 well 3 highest 2 fast 1 youngest 1 oldest 1 lowest 1 long 1 ko→wt 1 -psmb10 1 -chest Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 6 github.com 4 doi.org 3 else4.de 2 www.cdc.gov 2 clinicaltrials.gov 2 clinical-virology.net 2 clients.adaptivebiotech.com 1 www.uni-duesseldorf.de 1 www.siopen-r-net.org 1 www.nrz-hygiene.de 1 www.informatik.uni-ulm.de 1 www.hivbook.com 1 www.genedb.org 1 www.expasy.org 1 www.ebmt.org 1 www.ctmm.nl 1 www.csbio.sjtu.edu.cn 1 www.clinicaltrials.gov 1 www.cbs.dtu.dk 1 www.awmf 1 recombineering.ncifcrf.gov 1 portal 1 phobius.sbc.su.se 1 pathema.jcvi.org 1 daignet.de 1 creativecommons.org 1 blast.ncbi.nlm.nih.gov 1 asheducationbook.hematologylibrary 1 clinicaltrials.gov 1 adz.cf.ac.uk Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 4 http://github.com/ml-jku/DeepRC 2 http://github.com/spro/practical-pytorch 2 http://doi.org/10.3904/kjim.2018.036 2 http://clients.adaptivebiotech.com/pub/Emerson-2017-NatGen 1 http://www.uni-duesseldorf.de/AWMF/ll/ 1 http://www.siopen-r-net.org 1 http://www.nrz-hygiene.de/surveillance/onko.htm] 1 http://www.informatik.uni-ulm.de/ni/mitarbeiter/HKestler/mra/app/index.php?plugin=form 1 http://www.hivbook.com 1 http://www.genedb.org 1 http://www.expasy.org/ 1 http://www.ebmt.org/Contents/About-EBMT/Who-We-Are/ScientificCouncil/Documents/IDWPdefiniti 1 http://www.ctmm.nl 1 http://www.csbio.sjtu.edu.cn/bioinf/Signal-3L/ 1 http://www.clinicaltrials.gov/ct2/show/NCT01560182? 1 http://www.cdc.gov/ncidod/hip/NNIS/members/pneumonia/Final/PneumoCriteriaV1.pdf 1 http://www.cdc.gov/mmwr 1 http://www.cbs.dtu.dk/services/SecretomeP 1 http://www.awmf 1 http://recombineering.ncifcrf.gov 1 http://portal 1 http://phobius.sbc.su.se/ 1 http://pathema.jcvi.org/cgi-bin/Entamoeba/PathemaHomePage.cgi 1 http://else4.de/m6o7g 1 http://else4.de/l9p8v 1 http://else4.de/0cydi 1 http://doi.org/10.1038/s41598-019-44922-9.Competing 1 http://doi.org/10 1 http://daignet.de/site-content/hiv-therapie/ 1 http://creativecommons.org/licenses/by/4.0/ 1 http://clinicaltrials.gov/ct2/show/NCT03009708 1 http://clinicaltrials.gov 1 http://clinical-virology.net/en/charts/chart/ctype/count/ 1 http://clinical-virology.net/en/charts/chart/ctype/ 1 http://blast.ncbi.nlm.nih.gov/Blast.cgi 1 http://asheducationbook.hematologylibrary 1 http://ClinicalTrials.gov 1 http://AdZ.cf.ac.uk Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 1 info@cbs.knaw.nl 1 beatrix.grubeck-loebenstein@oeaw.ac.at Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 70 transplant related mortality 68 patients are alive 41 patients did not 32 patients undergoing hsct 28 treatment related mortality 26 patients were alive 20 % were male 20 patients received myeloablative 17 cells did not 16 cells was significantly 15 patient did not 15 patients had grade 15 patients were male 14 patients developed acute 14 patients undergoing allo 13 patients developed grade 13 patients were not 12 infections are more 12 patients received bone 12 patients were eligible 12 therapy is not 11 cells are not 11 donor was unrelated 11 infection is common 11 patients do not 11 patients had normal 11 patients had significantly 11 patients received hsct 11 patients undergoing bone 11 patients were evaluable 10 patient developed grade 10 patients are still 10 patients developed chronic 10 patients developed cmv 10 patients had acute 10 patients received atg 10 patients received fludarabine 10 patients were also 9 cells do not 9 cells were not 9 cells were significantly 9 groups were comparable 9 infection is usually 9 patients are currently 9 patients developed agvhd 9 patients developed severe 9 patients were males 9 study did not 8 % had grade 8 donors were hla Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 5 donor is not available 2 cells had no effect 2 cells were not different 2 donors are not available 2 groups were not statistically 2 infection is not well 2 patients is not clear 2 patients were not evaluable 2 transplantation had no impact 2 transplantation were not significantly 2 treatment had no impact 1 % had no detectable 1 % had no proteinuria 1 % has no negative 1 % is not much 1 % reported no change 1 % showed no signs 1 % showing no response 1 % was not statistically 1 case is not valuable 1 cases have no identifiable 1 cases is not sufficiently 1 cases showed no different 1 cells are not indicators 1 cells are not necessary 1 cells are not preponderant 1 cells are not simply 1 cells do no longer 1 cells do not always 1 cells do not usually 1 cells had no significant 1 cells have not yet 1 cells is not available 1 cells is not due 1 cells showed no differentiation 1 cells was not relative 1 cells was not significantly 1 cells was not statistically 1 cells were not abundant 1 cells were not anergic 1 cells were not elevated 1 cells were not statistically 1 cmv was not part 1 days has no harmful 1 disease are not reliable 1 disease is not clearly 1 disease is not responsible 1 disease was not totally 1 diseases are not so 1 diseases are not unusual A rudimentary bibliography -------------------------- id = cord-342000-h4jo2bir author = Aggarwal, Ashim title = Early Cardiac Allograft Vasculopathy: Are the Viruses to Blame? date = 2012-05-31 keywords = CAV; CMV summary = doi = 10.1155/2012/734074 id = cord-340228-mvqoyror author = Al-Herz, Waleed title = Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date = 2019-05-29 keywords = CMV; EBV; Kuwait summary = Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The distribution of these patients according to PID categories is: immunodeficiencies affecting cellular and humoral immunity, 97 patients (35.4%); combined immunodeficiencies with associated syndromic features, 67 patients (24.5%); predominantly antibody deficiencies, 34 patients (12.4%); diseases of immune dysregulation, 47 patients (17.2%); congenital defects of phagocyte number or function, 17 patients (6.2%); autoinflammatory disorders, 1 patient (0.3%); and complement deficiencies, 11 patients (4%). doi = 10.3389/fimmu.2019.01231 id = cord-307016-4hdsb5oq author = Allen, Upton title = Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children date = 2010-04-30 keywords = CMV; EBV; infection; recipient; transplant summary = doi = 10.1016/j.pcl.2010.01.005 id = cord-257114-pxmflm2c author = BURGUETE, SERGIO R. title = Lung transplant infection date = 2012-12-26 keywords = BOS; CMV; LTR; infection; lung; transplant summary = doi = 10.1111/j.1440-1843.2012.02196.x id = cord-016478-gpl0zbvd author = Barry, Maura title = Cytopenias in Transplant Patients date = 2018-12-08 keywords = CMV; ITP; patient; transplant summary = The differential diagnosis for anemia after solid organ transplant includes hemolysis, drug toxicities, iron deficiency, infection, posttransplant lymphoproliferative disorder, graft-vs.-host disease, and hemophagocytic syndrome. Sirolimus and calcineurin inhibitors such as tacrolimus and cyclosporine have been shown in renal and lung transplant recipients to cause hemolytic anemia, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome [15] [16] [17] . While this etiology is more often identified as a drug-related phenomenon, particularly due to the immunosuppressants required to prevent organ rejection (see next section), there have been multiple case reports associating CMV infection as a trigger of TMA in the posttransplant setting [53, 54] . When this is identified, numerous case studies in multiple different organ systems (lung, liver, kidney solid organ transplant) have reported that changing from one CI to another (tacrolimus to cyclosporine or vice versa) or to another class of medication such as sirolimus or mycophenolate mofetil can prevent further episodes of TMA from occurring [61] [62] [63] [64] . doi = 10.1007/978-1-4939-9034-4_10 id = cord-354325-r73datur author = Berger, Mitchell title = Therapeutic Applications of Monoclonal Antibodies date = 2002-07-31 keywords = CMV; MAbs; antibody; antigen; cell; human; monoclonal; mouse summary = doi = 10.1097/00000441-200207000-00004 id = cord-005794-3u4iu41r author = Berner, Michel E. title = High frequency oscillatory ventilation for respiratory failure due to RSV bronchiolitis date = 2008-05-24 keywords = CMV; HFOV summary = doi = 10.1007/s00134-008-1151-3 id = cord-354374-rtgjjglc author = C.G. Pollok, Richard title = Enteric viruses in HIV-related diarrhoea date = 2000-12-01 keywords = CMV; HIV summary = doi = 10.1016/s1357-4310(00)01816-5 id = cord-279638-jr1mbh7s author = Calore, Elisabetta title = Treatment of Acute Graft-versus-Host Disease in Childhood with Extracorporeal Photochemotherapy/Photopheresis: The Padova Experience date = 2015-07-14 keywords = CMV; ECP; HSCT summary = Acute graft-versus-host disease (aGVHD) is the major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Update on the mechanism of action and on clinical efficacy of extracorporeal photopheresis in the treatment of acute and chronic graft versus host disease in children Extracorporeal photopheresis (photochemotherapy) in the treatment of acute and chronic graft versus host disease: immunological mechanisms and the results from clinical studies Role of extracorporeal photopheresis (ECP) in treatment of steroid-refractory acute graft-versus-host disease Extracorporeal Photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommendations from an Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and Italian Group for Bone Marrow Transplantation (GITMO) consensus process Extracorporeal photopheresis for steroid resistant graft versus host disease in pediatric patients: a pilot single institution report Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients doi = 10.1016/j.bbmt.2015.07.007 id = cord-347761-wgodcsav author = Cant, Andrew title = Infections in the Immunocompromised date = 2009-10-24 keywords = CMV; CVC; HSCT; PCP; infection summary = doi = 10.1007/978-1-4419-0981-7_1 id = cord-348130-t9tysvr8 author = Cho, Sung-Yeon title = Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea date = 2018-02-27 keywords = CMV; GVHD; HSCT; Korea; PCP; patient summary = In addition, the types and risk factors of infectious complications differ according to the stem cell source, donor type, conditioning intensity, region, prophylaxis strategy, and comorbidities, such as graft-versushost disease and invasive fungal infection. Bacteria: consider fluoroquinolone a Fungus: consider prophylaxis during neutropenia, consider PCP prophylaxis Virus: during neutropenia or longer depending on risks HSCT, hematopoietic stem cell transplantation; PCP, Pneumocystis jirovecii pneumonia; GVHD, graft-versus-host disease; TNF-α, tumor necrosis factor-α. In a systematic review and meta-analysis of non-HIV immunocompromised hosts (patients with acute leukemia and recipients of HSCT and solid organ transplant), the incidence of PCP was reduced by 91% (relative risk [RR], 0.09) in trimethoprim/sulfamethoxazole prophylaxis group compared with placebo [69, 70] . Epidemiology and risk factors for invasive fungal diseases among allogeneic hematopoietic stem cell transplant recipients in Korea: results of doi = 10.3904/kjim.2018.036 id = cord-010130-28bt3x25 author = Crocchiolo, R. title = Infections after T‐replete haploidentical transplantation and high‐dose cyclophosphamide as graft‐versus‐host disease prophylaxis date = 2015-03-26 keywords = CMV; HSCT; day summary = RESULTS: After a median follow‐up of 23 months, cumulative incidence of viral infections was 70% (95% confidence interval [CI] 59–81) at 100 days and 77% (95% CI 67–87) at 1 year; 35 of 65 patients at risk had CMV reactivation (54%) and the rate of polyomavirus‐virus‐associated cystitis was 19% (13/70). In the present analysis, we described infectious complications after unmanipulated, T-cell replete haplo-HSCT using post-transplant Cy in 70 consecutive patients and found, aside from a high incidence of viral infections/reactivations, especially in the early posttransplant period, a quite low incidence of late bacterial infections, together with a very low incidence of IFIs after day +180 (2 events in the overall 11 observed). In conclusion, the present single-center data on 70 consecutive patients receiving T-cell replete haplo-HSCT with post-transplant Cy confirm a high rate of viral infections before day +100 and a lower incidence of infections afterward, suggesting a satisfactory although non-optimal immune reconstitution after this type of transplantation. doi = 10.1111/tid.12365 id = cord-293886-gbv1ipmn author = Cunha, Burke A. title = Severe cytomegalovirus (CMV) community-acquired pneumonia (CAP) in a nonimmunocompromised host date = 2008-10-01 keywords = CMV; cap summary = doi = 10.1016/j.hrtlng.2008.05.008 id = cord-259194-9zllvfqb author = Cupples, Sandra A. title = Transplant Infectious Disease: Implications for Critical Care Nurses date = 2011-11-02 keywords = CMV; EBV; infection; transplant summary = doi = 10.1016/j.ccell.2011.08.001 id = cord-018331-ovmtz4sb author = Dancygier, Henryk title = Viral Infections by Nonhepatotropic Viruses date = 2010 keywords = CMV; HSV; hepatitis summary = doi = 10.1007/978-3-642-04519-6_10 id = cord-018659-rxzy6k3b author = Danziger-Isakov, Lara title = Posttransplant Complications and Comorbidities date = 2018-01-08 keywords = CMV; infection; lung summary = doi = 10.1007/978-3-319-07284-5_71 id = cord-348547-wmvqvbqi author = Desmons, Aurore title = Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death date = 2013-10-31 keywords = CMV; SUID; VZV summary = title: Post-mortem diagnosis, of cytomegalovirus and varicella zoster virus co-infection by combined histology and tissue molecular biology, in a sudden unexplained infant death Objectives To describe post-mortem combined histological and tissue molecular biological techniques for the diagnosis of cytomegalovirus and varicella zoster virus co-infection as a cause of death. Study design Real-time quantitative PCR and RT-PCR assays for Herpesviruses, respiratory viruses, Adenovirus, Enterovirus and Parvovirus B19 were performed on multi-organ frozen samples and paraffin-embedded tissues in combination with histology. Conclusions This case shows that thorough quantitative virological investigations on frozen tissues must be performed in combination with histology and immunohistochemistry for the determination of the cause of a sudden unexplained infant death. Post-mortem virological quantitative molecular analyses performed on frozen tissue samples revealed cytomegalovirus (CMV) and varicella zoster virus (VZV), mainly in the lungs. However, pulmonary necrotizing inflammatory lesions, immunohistochemistry, and molecular detection of CMV and VZV in multi-organs samples demonstrated the role of the co-infection in the death. doi = 10.1016/j.jcv.2013.08.007 id = cord-018545-fk17n2bx author = Dorofaeff, Tavey title = Infections in the PICU date = 2012 keywords = CMV; HIV; HSV; PICU; care; cause; child; infection; patient summary = doi = 10.1007/978-3-642-02202-9_268 id = cord-006841-3u56erru author = Einsele, Hermann title = Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date = 2003-09-10 keywords = CMV; cell; infection; patient summary = The number of stem cells in the graft and the type of GvHD prophylaxis are factors which determine the rate of hematopoeitic reconstitution and may therefore also influence incidence and severity of infections during the early post-transplantation period. Modification of empiric antimicrobial regimens in patients with neutropenic fever after allogeneic stem cell transplantation When the causative agent of an infection has been identified, antibacterial therapy should be adapted according to the resistance pattern of the pathogen. If fever occurs in a patient later than 100 days after allogeneic stem cell transplantation, the upper and lower respiratory tract (bronchitis, pneumonia, sinusitis), and bacteremias have to be considered as specific foci of infections. Clinical manifestations of adenovirus infections in patients after allogeneic stem cell transplantation that have been reported so far include pneumonia, hepatitis, cystitis, diarrhea, and also disseminated disease (for diagnostic procedures see Table 3 ). doi = 10.1007/s00277-003-0772-4 id = cord-269194-b1wlr3t7 author = Engstrom-Melnyk, Julia title = Chapter 5 Clinical Applications of Quantitative Real-Time PCR in Virology date = 2015-12-31 keywords = CMV; FDA; HCV; HIV; HIV-1; PCR; RNA; viral summary = Complementing serologic testing by detecting infections within the pre-seroconversion window period and infections with immunovariant viruses, real-time PCR provides a highly valuable tool for screening, diagnosing, or monitoring diseases, as well as evaluating medical and therapeutic decision points that allows for more timely predictions of therapeutic failures than traditional methods and, lastly, assessing cure rates following targeted therapies. Beyond this, quantitative real-time PCR facilitates advancements in the quality of diagnostics by driving consensus management guidelines following standardisation to improve patient outcomes, pushing for disease eradication with assays offering progressively lower limits of detection, and rapidly meeting medical needs in cases of emerging epidemic crises involving new pathogens that may result in significant health threats. With the development and administration of newer drugs that target specific biological processes of HIV, routine and clinical monitoring of viral loads using a real-time quantitative PCR assay continues to be critical to predict treatment failure and early emergence of drug resistance mutations, within a timeframe that would increase subsequent treatment success. doi = 10.1016/bs.mim.2015.04.005 id = cord-018393-5jlqn7wq author = Finke, Ernst-Jürgen title = Bioterrorismus, infektiologische Aspekte date = 2011-12-14 keywords = Antikörper; Blut; CMV; Ektoparasiten; Erkrankung; Erreger; Fieber; GBV; Hepatitis; Infektion; Menschen; Nachweis; Patienten; Regel; Tage; Therapie; Virus; auf; bei; der; des; die; durch; eine; ist; mit; nicht; oder; sind; und; von; werden summary = Wenn sie sich jedoch verstärkt, kann man sie leicht erkennen, aber nur schwer heilen." (Nicolo Macchiavelli, 1449 -1527 Es ist wenig wahrscheinlich, dass biologische Anschläge rechtzeitig als solche erkannt werden, sofern kein automatisches Monitoring mit einem zuverlässigen Echtzeit-Nachweis von B-Agenzien existiert. B. Enzephalitiden viraler Genese sowie die Frühstadien von nvCJD und möglicherweise auch die Frühsymptomatik der Alzheimer-Krankheit; außerdem die Borreliose-Infektion (Neuroborreliose), bei der ein heterogenes Symptomenbild angenommen wird, das sich wenig mit der Ausprägung einer (BDV-spezifischen) Dysfunktion im limbischen System deckt. Unklar ist jedoch, wie häufig sich aus initial milden Infektionen der oberen Luftwege eine Bronchitis oder eine Pneumonie entwickelt und was die auslösenden Faktoren dafür sind. Beim Nachweis hoch positiver (häufig mit anderen Chlamydienspezies kreuzreagierender) Antikörper ist bei entsprechender klinischer Symptomatik die gezielte Erhebung der Anamnese hinsichtlich einer möglichen Exposition des Patienten gegenüber den natürlichen Wirten diagnostisch wegweisend. Aus Patientenseren wurden Cyclospora-spezifische Antikörper isoliert, jedoch sind die Vorgänge der Immunantwort auf Cyclospora noch nicht vollständig geklärt und ob sich eine Immunität entwickelt, ist fraglich. doi = 10.1007/978-3-642-17158-1_3 id = cord-022472-q2qtl26d author = Fishman, Jay A. title = Infection in Renal Transplant Recipients date = 2009-05-15 keywords = CMV; EBV; PTLD; infection; recipient; transplant summary = doi = 10.1016/b978-1-4160-0158-4.50041-0 id = cord-017782-dtveihrj author = Fong, I. W. title = Litigations for HIV Related Complications date = 2010-11-30 keywords = AIDS; CD4; CMV; HIV; cell summary = doi = 10.1007/978-1-4419-8053-3_13 id = cord-001690-cn21fgug author = Franceschi, Valentina title = BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1((-/-)) Mice from Monkeypoxvirus Lethal Challenge date = 2015-06-18 keywords = CMV; EF1α; MPXV; m1r; ΔTK summary = In the present study, a new vaccination strategy approach based on three recombinant bovine herpesvirus 4 (BoHV-4) vectors, each expressing different MPXV glycoproteins, A29L, M1R and B6R were investigated in terms of protection from a lethal MPXV challenge in STAT1 knockout mice. In vivo efficacy testing of BoHV-4-A-CMV-A29LgD 106 ΔTK, BoHV-4-A-EF1α-M1RgD 106 ΔTK and BoHV-4-A-EF1α-B6RgD 106 ΔTK To test the efficacy of the vectors in vivo, we sought to determine if they could protect mice against a lethal challenge with MPXV. Since the purpose of this study was to determine the capability of BoHV-4-based viral vectors to protect STAT1 (-/-) mice against a lethal MPXV infection, the first concern was the generation of optimized expression cassettes to be integrated into the BAC-BoHV-4-A genome that were able to efficiently express A29L, M1R and B6R antigens. In summary, our findings have demonstrated that BoHV-4 based vectors can be used as vaccines to protect against a lethal MPXV challenge in mice. doi = 10.1371/journal.pntd.0003850 id = cord-274012-56i4sikj author = Gavaldà, Joan title = Infección en el trasplante de pulmón date = 2007-11-30 keywords = CMV; del; los summary = doi = 10.1157/13112940 id = cord-019009-3ngfv96u author = Gea-Banacloche, Juan title = Risks and Epidemiology of Infections After Hematopoietic Stem Cell Transplantation date = 2016-02-15 keywords = CMV; GVHD; HCT; cell; infection; risk summary = Several characteristics of the transplant infl uence the risk of infection: the conditioning preparative regimen, the source of stem cells, the degree of HLA identity between donor and recipient, and the prophylactic strategy adopted to prevent GVHD (use of T cell depletion or immunosuppressive medications). These factors may result in increased risk of infections associated with T cell immunodefi ciency, like CMV, Pneumocystis jirovecii pneumonia (PCP), and Epstein-Barr virus (EBV)-related posttransplant lymphoproliferative disorder (PTLD). Risk factors for recurrence of invasive fungal infection during secondary antifungal prophylaxis in allogeneic hematopoietic stem cell transplant recipients Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: a retrospective survey of the infectious diseases working party of the european group for blood and marrow transplantation Infl iximab use in patients with severe graftversus-host disease and other emerging risk factors of noncandida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study doi = 10.1007/978-3-319-28797-3_6 id = cord-311505-akcc9oms author = Geisen, Will R. title = Cytomegalovirus Enterocolitis secondary to experimental COVID-19 therapy date = 2020-09-22 keywords = CMV; COVID-19 summary = Additionally, this case validates colonoscopy as a mode to rule out concurrent infectious etiologies causing diarrhea in COVID-19-positive patients. Additionally, this case validates colonoscopy as a mode to rule out concurrent infectious etiologies causing diarrhea in COVID-19-positive patients. The novel 2019 coronavirus (COVID-19), a form of severe acute respiratory syndrome (SARS-CoV-2), has caused a pandemic of historical proportions. Due to its worldwide distribution, a paucity of clinical trial data, and a high mortality rate, the COVID pandemic has led to widespread implementation of experimental therapies with varying levels of success and, in some instances, poor outcomes (3, 4, 5) . We present a patient who was treated with experimental therapies and subsequently developed severe gastrointestinal pathology that was diagnosed by colonoscopy. The report describes a patient with SARS-CoV-2 pneumonia who was treated with experimental immunomodulating therapies and, subsequently, developed cytomegalovirus (CMV) colitis. doi = 10.1016/j.idcr.2020.e00962 id = cord-006586-49btg9w7 author = Golfieri, R. title = Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases date = 2000 keywords = CMV; OLT; infection; pulmonary summary = doi = 10.1007/s003309900268 id = cord-011030-o4jn5883 author = Hakki, Morgan title = Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy date = 2020-01-24 keywords = CMV; HCT; UL97; dna summary = doi = 10.1007/s11899-020-00557-6 id = cord-004643-uu4uipfy author = Hasan, Mohammad Rubayet title = Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date = 2020-03-20 keywords = CMV; HLH; patient summary = Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria. Whole genome sequencing (WGS) of the MDR bacteria and metagenomic analysis of his blood sample revealed an unusual accumulation of a wide range of antimicrobial resistance mechanisms in a single patient, including antiviral resistance to ganciclovir, and resistance mechanisms to all currently available antibiotics. Ganciclovir resistance was confirmed by the presence of the A594V mutation in UL97 [6] What was unique in our patient compared to other reported CMV-associated HLH cases was the overwhelming infection with MDROs. On hospital admission, the patient was found to be colonized with multiple MDROs including VRE, and carbapenamase-producing Enterobacteriaceae, which may have been acquired during his previous hospital course in India. doi = 10.1186/s12879-020-04966-z id = cord-017030-tzuyo6tx author = Henao-Martínez, Andrés F. title = Infections in Heart, Lung, and Heart-Lung Transplantation date = 2018-12-08 keywords = CMV; aspergillus; heart; infection; lung; recipient; transplant; transplantation summary = There are several factors predisposing thoracic transplant recipients to infections: (A) factors present before transplantation: age, presence of comorbidities (e.g., chronic kidney disease, diabetes mellitus, cancer, etc.), nutrition status, latent infections, colonization with healthcare-associated organisms, and occult community-acquired infections; (B) factors during the surgery: duration of the transplant procedure, graft injury including ischemic time, colonization or latent infection of the graft, surgical instrumentation (e.g., mechanical ventilation, invasive devices such as catheters, drains, Foley catheters, etc.), ICU stay, and need for re-interventions; and (C) factors present after transplant: degree of immunosuppression, CMV infection, and rejections ( Mechanical ventilation (MV) for >5 days immediately following transplant surgery and isolation of Staphylococcus aureus (SA) from airway cultures in the recipient were considered risk factors for invasive SA infections in a retrospective study of patients with lung and heart-lung transplants [20] . doi = 10.1007/978-1-4939-9034-4_2 id = cord-017012-yl0vanuh author = Herberg, Jethro title = Infectious Diseases and the Kidney date = 2009 keywords = BKV; CMV; HBV; HIV; HIVAN; acute; case; disease; infection; patient; renal summary = doi = 10.1007/978-3-540-76341-3_52 id = cord-016903-z2vqfq98 author = Herndler-Brandstetter, Dietmar title = The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly date = 2007 keywords = CMV; age; elderly; person; vaccine summary = doi = 10.1007/978-0-387-76842-7_10 id = cord-004059-furt6xcn author = Hraiech, Sami title = Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO date = 2019-12-23 keywords = CMV; ECMO; HSV summary = However, little is known about herpes simplex virus (HSV) and Cytomegalovirus (CMV) reactivation occurring in patients with severe ARDS under veno-venous extracorporeal membrane oxygenation (ECMO). The following data were retrospectively recorded from the patients'' medical file: age, sex, Simplified Acute Physiologic Score II (SAPS II) [21] , Sequential Organ Failure Assessment (SOFA) score [22] , presence of co-morbidities, presence of previous immunosuppression, cause of ARDS, date of MV initiation, date of ECMO implementation, other organ failure associated with ARDS during ICU stay (in particular need for catecholamines or renal replacement therapy), blood transfusion, post-aggressive pulmonary fibrosis (defined by an alveolar procollagen III higher than 9 µg/l) [23] , time of HSV/CMV reactivation, delay between MV and HSV/CMV reactivation, delay between ECMO and HSV/CMV reactivation, duration of MV (from the day of intubation to the day of MV weaning), ECMO duration (from the day of ECMO implementation to its removal or death), ECMO-free days at day 28, ventilator-free days (VFD) at day 28, ICU length of stay [from the day of ICU admission (in the first ICU if the patient was referred from another hospital) to discharge], hospital length of stay [from the admission to hospital (in the original hospital if the patient was referred from another hospital) to discharge to home or to rehabilitation ward], ICU and hospital mortality, acyclovir or ganciclovir treatment after reactivation under ECMO. doi = 10.1186/s13613-019-0616-6 id = cord-276343-sb3vd7fq author = Humar, Atul title = Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date = 2006-12-31 keywords = CMV; patient; transplant summary = doi = 10.1016/j.healun.2006.09.015 id = cord-280374-yj0r4rwt author = Jain, Richa title = Hepatic sinusoidal-obstruction syndrome and busulfan-induced lung injury in a post-autologous stem cell transplant recipient date = 2018-01-04 keywords = CMV; SOS; hepatic; lung summary = doi = 10.1007/s13312-017-1172-5 id = cord-296402-rd5clf8h author = José Castón, Juan title = Efectos de la infección viral en el paciente trasplantado date = 2007-10-31 keywords = CMV; ELPT; por summary = Respecto al citomegalovirus (CMV), tanto la reactivación como la infección adquirida en período peritrasplante, suelen producirse entre el primero y el cuarto mes postrasplante, aunque en la actualidad se describen cada Las infecciones virales continúan siendo una importante causa de morbimortalidad en los pacientes trasplantados. Igualmente, en otro ensayo que comparó valganciclovir con ganciclovir oral en Castón profilaxis durante 90 días en receptores de TOS (hepático, cardíaco, renal y páncreas y riñón) en situación D+/R-, se observó cómo en ambos grupos todos los casos de enfermedad por CMV aparecieron después de los primeros 6 meses postrasplante 18 . De esta forma, los receptores seronegativos que reciben órganos de donantes seropositivos presentan entre 10 y 50 veces mayor riesgo de ELPT como consecuencia del desarrollo de infección primaria por VEB 27 . doi = 10.1157/13109990 id = cord-347064-ljd121no author = José, Ricardo J. title = Opportunistic bacterial, viral and fungal infections of the lung date = 2016-05-05 keywords = CMV; infection; patient summary = doi = 10.1016/j.mpmed.2016.03.015 id = cord-335692-5uxtua9o author = Kilic, A. title = Evaluation of the performance of DiaSorin molecular Pneumocystis jirovecii-CMV multiplex real-time PCR assay from bronchoalveolar lavage samples date = 2020-01-31 keywords = CMV summary = doi = 10.1016/j.mycmed.2020.100936 id = cord-022752-bdve1ydv author = Knuf, Markus title = Infektiologie date = 2019-08-09 keywords = Bakterien; Behandlung; CMV; Erreger; Fieber; Gruppe; Impfung; Infektion; Kindern; Patienten; Symptome; Tage; Therapie; Wochen; bei; der; diagnose; die; eine; ist; mit; sind; und; von; werden summary = Zu den primär durch eine Blickdiagnose zu diagnostizierenden Infektionskrankheiten gehören auch die Windpocken (Varizellen) (› Abb. 10.5) mit kurz vor Exanthemausbruch bestehendem Fieber sowie Kopf-und Gliederschmerzen. Expositionsanamnese / Grundkrankheit (Disposition) Bei Kenntnis von zwei der drei genannten Faktoren kann auf den dritten geschlossen und eine kalkulierte antiinfektive Therapie begonnen werden. Wichtig für den klinischen Alltag sind nicht so sehr die Sensitivität und Spezifität eines Testverfahrens (Qualitätsmerkmale des Testverfahrens), sondern vor allem der positive bzw. Patienten mit einer Immundefizienz können abhängig von der vorliegenden Funktionsstörung oft auf Impfungen nicht adäquat reagieren und werden durch Lebendimpfstoffe u. Da der übermäßige Antibiotikaverbrauch zur Resistenzentwicklung beiträgt und Antibiotika Nebenwirkungen verursachen, ist eine möglichst zielgerechte Therapie für Patienten mit AOM, die wirklich davon profitieren, anzustreben. Da die normale Mundflora aus vielen verschiedenen Bakterienspezies besteht, wobei sowohl grampositive Erreger (grüne Streptokokken, β-hämolysierende Streptokokken) als auch Anaerobier und Actinomyzeten besonders häufig vorkommen, kann sich bei Prädisposition leicht eine Infektion entwickeln. doi = 10.1016/b978-3-437-21661-9.00010-8 id = cord-315304-pge45105 author = Kotton, C.N. title = Organ Transplantation, Risks date = 2015-03-06 keywords = CMV; HHV-6; infection; transplantation summary = Viral infection is associated with both direct (invasive disease) and indirect (immune modulation) effects affecting susceptibility to other infections and promoting allograft rejection. The risk for viral infection is a function of the intensity of exposure and virulence of the specific virus, the intensity of immune suppression used to prevent graft rejection or graft-versus-host disease, underlying immune deficits, and factors affecting host susceptibility. Multiple factors contribute to viral reactivation after transplantation, including graft rejection and therapy, immune suppression (especially reduction of T-cell mediated, cytotoxic immunity), inflammation, and tissue injury. The clinical presentation of CMV (HHV-5) can range from a ''CMV syndrome'' including fever, malaise, leukopenia, to a ''flu-like'' illness with myalgias and fatigue, to a more significant end-organ disease with pneumonitis, colitis, encephalitis, hepatitis, or chorioretinitis. The treatment of viral infections in the renal transplantation recipient includes: the reduction of immunosuppression, antiviral therapy, diagnosis and treatment of co-infections (such as CMV, EBV, HHV-6, or À7), and use of adjunctive therapies such as immunoglobulins or colony stimulating factors. doi = 10.1016/b978-0-12-801238-3.02629-5 id = cord-266218-r6xg9zts author = Law, Arjun Datt title = Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies date = 2018-08-07 keywords = ATG; CMV; EBV; GVHD summary = doi = 10.1016/j.bbmt.2018.07.008 id = cord-305085-bv7udg9k author = Lawrence, Robert M. title = Chapter 13 Transmission of Infectious Diseases Through Breast Milk and Breastfeeding date = 2011-12-31 keywords = CMV; HBV; HCV; HIV; HTLV; MRSA; Nile; West; breast; infant; infection; milk; mother; transmission summary = Postnatal exposure of susceptible infants to CMV, including premature infants without passively acquired maternal antibodies against CMV, infants born to CMV-seronegative mothers, and immunodeficient infants, can cause significant clinical illness (pneumonitis, hepatitis, thrombocytopenia).* In one study of premature infants followed up to 12 months, Vochem et al 430 found CMV transmission in 17 of 29 infants (59%) exposed to CMV virolactia and breastfed compared with no infants infected of 27 exposed to breast milk without CMV. 38, 104, 121 Laboratory reports demonstrate the presence of cell-free virus and cell-associated virus in breast milk as well as various immunologic factors that could block or limit infection.* A dose-response relationship has been observed, correlating the HIV viral load in human milk as well as a mother'' s plasma viral load with an increased transmission risk for the breastfed infant. 76 No case of transmission of yellow fever virus from an infected mother to her infant via breastfeeding or breast milk has been reported. doi = 10.1016/b978-1-4377-0788-5.10013-6 id = cord-290976-dhwlr2ui author = Lednicky, John A title = Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells date = 2013-06-27 keywords = CMV; LLC; MK2; NL63; PCR; RPTEC summary = doi = 10.1186/1743-422x-10-213 id = cord-003085-7krf1yxz author = Li, Xi title = Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta-analysis date = 2018-06-28 keywords = CMV; ICU summary = doi = 10.1186/s12879-018-3195-5 id = cord-016267-idrc1sdh author = Ljungman, Per title = Viral Infections in Hematopoietic Stem Cell Transplant Recipients date = 2009-11-27 keywords = CMV; SCT; cell summary = As early identification of patients at risk for developing viral disease reduces virus-related morbidity and mortality, monitoring with sensitive techniques such as antigenemia or quantitative PCR is indicated in all allogeneic SCT patients. Although the incidence of EBV-PTLD is generally lower than 2% following allogeneic SCT, it may increase up to 20% in patients with risk factors such as mismatched donor SCT, the use of an EBV positive donor to an EBV negative recipient, T-cell depletion, ATG therapy, and other forms of intensified immunosuppression for prevention and treatment of GVHD [92, 93] . Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis doi = 10.1007/978-1-59745-478-0_29 id = cord-007575-5ekgabx5 author = Luby, James P. title = Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date = 2016-01-14 keywords = CMV; infection; influenza; patient; pneumonia; virus summary = doi = 10.1097/00000441-198707000-00007 id = cord-282618-tjvjlyn9 author = Luke, J M title = Improved antibiotic-free plasmid vector design by incorporation of transient expression enhancers date = 2010-11-25 keywords = CMV; HTLV; RNA; dna; figure summary = To maintain a low risk of insertional mutagenesis-mediated gene activation, expression-augmenting sequences would ideally function to improve transgene expression from transiently transfected intact plasmid, but not from spurious genomically integrated vectors. A neomycin resistance gene (NeoR) without an upstream Kozak sequence was cloned downstream of an enhanced green fluorescent protein (EGFP) transgene in different configurations similar to that used with PREs. Quantifiable neoR translation products were present in all tested configurations, as was biologically active neoR protein after plasmid transfection into both HEK293 and CHO cell lines (Supplementary Table S1 ). The assay was in the same format as in (a), except for the fact that Pol III inhibitor-treated cells were transfected with EGFP plasmids containing the CMV-HTLV-I R promoter with or without VA1; (c) Inhibition of PKR, not of adenosine deaminase acting on RNA (ADAR) or RNA interference (RNAI), was required for VA1 expression enhancement effect. doi = 10.1038/gt.2010.149 id = cord-016932-bej10xbf author = Lum, Lawrence G. title = Specific Adoptive T-Cell Therapy for Viral and Fungal Infections date = 2018-06-19 keywords = CMV; CTL; EBV; HSCT summary = doi = 10.1007/978-3-319-77674-3_20 id = cord-015922-5wwy0m2k author = Marty, Francisco M. title = Infection in the Hematopoietic Stem Cell Transplant Recipient date = 2008 keywords = CMV; GVHD; HSCT; infection; patient; therapy summary = doi = 10.1007/978-1-59745-438-4_19 id = cord-023669-3ataw6gy author = Masur, Henry title = Critically Ill Immunosuppressed Host date = 2009-05-15 keywords = CD4; CMV; HIV; ICU; infection; patient; therapy summary = As the population of patients with cancer, organ transplants, vasculitides, and human immunodefi ciency virus (HIV) infection has grown, intensivists are seeing more and more patients with altered immunity. For instance, if a patient presents with severe hypoxemia and diffuse pulmonary infi ltrates, a health care provider who recognizes a prior splenectomy as the major predisposition to infection would focus the diagnostic evaluation and the empiric therapy on Streptococcus pneumoniae and Haemophilus infl uenzae. Patients with HIV infection develop clinical disease as a result of three basic processes: the direct effect of HIV on specifi c organs (e.g., cardiomyopathy, enteropathy, dementia); immunologically mediated processes (e.g., glomerulonephritis, thrombocytopenia); or opportunistic infections and tumors that are enabled by HIV-induced immunosuppression. For instance, if a patient with HIV infection and a CD4+ T lymphocyte count of 700 cells/µL presents with diffuse pulmonary infi ltrates, the diagnostic evaluation and empiric antimicrobial regimen should focus on S. doi = 10.1016/b978-032304841-5.50056-x id = cord-018943-5zf0eya3 author = Michels, Guido title = Transplantationsmedizin in der Intensivmedizin date = 2011-09-22 keywords = CMV summary = doi = 10.1007/978-3-642-16841-3_24 id = cord-323691-5s5almd2 author = Mishin, Vasiliy P title = A ‘minimal’ approach in design of flavivirus infectious DNA date = 2001-12-04 keywords = CMV; RNA; dna summary = Abstract The ''infectious DNA'' approach, which is based on in vivo transcription of (+)RNA virus genome cDNA cassettes from eukaryotic promoters in transfected cells, became a popular alternative to the classical scheme in the infectious clone methodology. Substantial difficulties, however, were encountered in design of flavivirus ''infectious DNA'', requiring either modification of the viral genome cassette (Yamshchikov et al., 2001) to prevent unwanted expression of viral genome segments encoding toxic for Escherichia coli products, or deletion of the structural protein region (Varnavski et al., 2000) . For this reason we sought to investigate if the stability of constructs containing an unmodified virus genome cassette can be improved by preventing its deleterious expression at the transcriptional level, i.e. by minimizing spurious transcription from eukaryotic promoters in E. doi = 10.1016/s0168-1702(01)00371-9 id = cord-004986-en7taikk author = Nagy, Nathalie title = Infections gastro-intestinales chez le patient immunocompromis date = 2002 keywords = AIDS; CD4; CMV; HIV; les; patient summary = doi = 10.1007/bf03016656 id = cord-018785-tcr5xlf8 author = Nambiar, Puja title = Infection in Kidney Transplantation date = 2018-06-27 keywords = Blumberg; CMV; HCV; HIV; infection; transplant summary = The immunosuppressive therapy required to prevent organ rejection places the kidney transplant recipient at increased risk for donor-derived, nosocomial, and community-acquired infections as well as reactivation of latent pathogens. The immunosuppressive therapy required to prevent organ rejection places the kidney transplant recipient at increased risk for donor-derived, nosocomial, and community-acquired infections as well as reactivation of latent pathogens. The risk factors for development of CMV disease include donor seropositivity/recipient seronegativity(Dþ/RÀ), use of induction immunosuppression (antilymphocyte antibodies), donor age >60 years, simultaneous kidney-pancreas transplantation, treatment for acute rejection, impaired transplant function, and concurrent infection from other viruses (like EBV and HHV-6 and 7) (De Keyzer et al. The risk factors for PTLD include EBV naïve recipients who receive EBV seropositive organs, active primary EBV infection, younger recipient, coinfection by CMV and other viruses, prior splenectomy, second transplant, acute or chronic graft versus host disease, immunosuppressive drug regimen (OKT3 or polyclonal antilymphocyte antibody), and the type of organ transplanted. doi = 10.1007/978-3-319-19617-6_22 id = cord-310217-p9nqcz5d author = Nikolina, Basic-Jukic title = Can hyperimmune anti-CMV globuline substitute for convalescent plasma for treatment of COVID-19? date = 2020-05-31 keywords = CMV summary = doi = 10.1016/j.mehy.2020.109903 id = cord-001938-n2d5fw2f author = Ong, David S. Y. title = Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome date = 2016-03-01 keywords = ARDS; CMV; ICU summary = Furthermore, CMV reactivation in critically ill patients has been associated with a prolonged duration of mechanical ventilation [2, 4, [9] [10] [11] [12] [13] , an increased length of stay in the ICU [3, 5, 9, 10, 13] , and excess mortality [2, 4, [7] [8] [9] . Nevertheless, it remains uncertain whether these findings imply that CMV reactivation is a truly independent risk factor with respect to these observed poor clinical outcomes because most studies that have assessed these associations did not adequately account for all possible sources of bias. Possible confounders that were screened included all patient characteristics and therapeutic interventions listed in Table 1 , and some markers of disease severity: Acute Physiology and Chronic Health Evaluation APACHE Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, COPD chronic obstructive pulmonary disease, ICU intensive care unit, PEEP positive end expiratory pressure, P/F partial pressure of oxygen in arterial blood to fraction of inspired oxygen ratio (APACHE) IV score, presence of septic shock, partial pressure of oxygen in arterial blood to fraction of inspired oxygen ratio, and positive end expiratory pressure (PEEP) setting. doi = 10.1007/s00134-015-4071-z id = cord-005225-7uuilki4 author = Paduch, Darius A. title = Viral lower urinary tract infections date = 2008-03-26 keywords = BKV; CMV; cystitis; hemorrhagic summary = doi = 10.1007/s11934-007-0080-y id = cord-272835-6nx4f8ss author = Paulsen, Grant C. title = Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation date = 2017-12-31 keywords = CMV; HSCT; LRTI; RSV; SOT; transplant summary = doi = 10.1016/j.ccm.2017.07.012 id = cord-021977-yu0hrg6h author = Pham, Phuong-Thu T. title = Medical Management of the Kidney Transplant Recipient: Infections and Malignant Neoplasms date = 2010-12-27 keywords = CMV; PTLD; infection; transplantation summary = doi = 10.1016/b978-0-323-05876-6.00101-5 id = cord-291960-1is0rv6c author = Piñana, José Luis title = Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia date = 2019-02-21 keywords = CMV; DNA; bal summary = doi = 10.1016/j.jinf.2019.02.009 id = cord-267269-05mezubh author = Plazolles, N. title = Pivotal Advance: The promotion of soluble DC‐SIGN release by inflammatory signals and its enhancement of cytomegalovirus‐mediated cis‐infection of myeloid dendritic cells date = 2010-10-12 keywords = CMV; FLAG; Fig; SIGN1AT1; sDC; sign summary = doi = 10.1189/jlb.0710386 id = cord-350807-qdq96723 author = Reckziegel, Maria title = Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection date = 2020-05-27 keywords = CMV; DNA; EBV; PCR summary = doi = 10.1007/s10096-020-03878-9 id = cord-304066-rirbdhz3 author = Reddehase, Matthias J. title = Adverse immunological imprinting by cytomegalovirus sensitizing for allergic airway disease date = 2019-05-10 keywords = AAD; CMV summary = doi = 10.1007/s00430-019-00610-z id = cord-288721-3bv3aak6 author = Schneider, Annika title = Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection date = 2019-06-11 keywords = CMV; Fig; Germany; liver; mitochondrion summary = Thus, single-organelle and multi-parameter resolution allows to explore altered energy metabolism and antiviral defence by tagged mitochondria selectively in virus-infected cells and will be instrumental to identify viral immune escape and to develop and monitor novel mitochondrial-targeted therapies. When challenged with high concentrations of calcium (100 µM), mitochondria isolated from virus-infected livers are much more fragile shown by time-dependent loss of membrane potential and change of their morphology indicated by decrease in side-scatter (Fig. 2F ). Number of viable mitochondria detected per second by flow-cytometry declined after calcium challenge, consistent with loss of mitochondrial integrity, and did so much faster in samples from virus-infected livers (Fig. 2F ). In order to further evaluate mitochondrial functionality, we challenged mitochondria with Ca 2+ as stress test and performed time kinetic measurements of DilC 1 (5) fluorescence and side-scatter of mito-DsRed + and mito-DsRed − mitochondria isolated from Ad-CMV-mitoRL infected livers. doi = 10.1038/s41598-019-44922-9 id = cord-023854-w8kx5n8k author = Schuster, V. title = Virusinfektionen date = 2019 keywords = CMV; EBV; HIV; HSV; Herpes; Infektion; Kindern; Therapie; VZV; Zellen; die; und summary = Anschließend dringt das Virus in die Nervenendigungen von peripheren sensorischen Nerven ein und wandert in ihnen retrograd bis zu den spinalen Hinterstrangganglien (bei HSV-1 meist Ganglion des N. Schleimhaut (Dermatom), wo es zur lokalen Virusvermehrung und Ausbildung von Bläschen kommt: Herpes zoster bei VZV, Herpes labialis oder genitalis bei HSV Die Infektion beginnt mit unspezifischen Symptomen (Fieber, Kopfschmerzen, Krankheitsgefühl) . VZV kann bei nachlassender zellulärer Immunität sowie durch noch unbekannte Mechanismen jederzeit reaktiviert werden: VZV wandert nun entlang der sensorischen peripheren Nerven anterograd an die Hautoberfläche, wo es im Bereich der betroffenen Dermatome zur Virusvermehrung mit Bläschenbildung (Herpes zoster) kommt. Inwieweit diese Komplikationen tatsächlich ursächlich nur durch HHV-6, oder möglicherweise erst in Verbindung mit zusätzlichen Infektionen (HIV, CMV und andere Herpesviren) hervorgerufen werden, ist derzeit nicht bekannt. Die Entwicklung eines Hydrops fetalis nach einer mütterlichen (und fetalen) Parvovirus-B19-Infektion ist insgesamt selten, sie liegt bei ca. doi = 10.1007/978-3-662-57295-5_14 id = cord-023729-dipjubn7 author = Serlin, Michael H. title = Gastrointestinal Disorders in HIV date = 2009-05-15 keywords = AIDS; CMV; HIV; patient summary = doi = 10.1016/b978-1-4160-2882-6.50027-7 id = cord-288945-c9ow1q5c author = Spengler, Ulrich title = Liver Disease Associated with Non-Hepatitis Viruses date = 2019-11-01 keywords = CMV; EBV; infection; virus summary = doi = 10.1016/b978-0-12-801238-3.65782-3 id = cord-283826-lgyc3sro author = Stiehm, E. Richard title = Therapeutic Use of Immunoglobulins date = 2010-11-05 keywords = CMV; IGIV; IVIG; antibody; immunoglobulin; infection; patient summary = doi = 10.1016/j.yapd.2010.08.005 id = cord-015139-s7ox0h4f author = Stockschläder, M. title = Atemwegsinfektionen bei immunsupprimierten Personen date = 2003 keywords = Amphotericin; CMV; Patienten; der; tag summary = Pul monale Veränderungen finden sich häufig bei immunsupprimierten Patienten und können durch die Grunderkrankung, deren Behandlung, Infektionen, Tumoren oder Kombinationen dieser Ursachen bedingt sein. Bei CMV-Infektionen findet man häufig eine Kombinationen von milchglasartiger, interstitieller Verschattung mit später disseminierten fleckförmigen Knötchen, wobei die Unter-und Mittelfelder betont betroffen sind [5] . Die Therapiestrategien "universelle Prophylaxe" und "preemptive treatment" der CMV-Erkrankung gelten auch für Patienten mit iatrogener Immunsuppression nach Organtransplantation. B. die CMV-Retinitis, bei 85% der AIDS-oder HIV-infizierten Patienten mit geringer CD4-Zahl beobachtet werden [57] . Zusammenfassend kann festge-stellt werden,dass für allogen stammzelltransplantierte Patienten und Hochrisikopatienten, die sich einer autologen BSZT unterziehen, eine Prophylaxe mit Fluconazol (400 mg/Tag) empfohlen wird [63] .Aspergillusinfektionen werden hierdurch allerdings nicht mit erfasst. Bei Patienten mit Lungeninfiltraten in der febrilen Neutropenie ist jedoch wegen fehlender Aspergilluswirksamkeit von Fluconazol bereits initial konventionelles oder liposomales Amphotericin B zu empfehlen. doi = 10.1007/s00103-002-0536-7 id = cord-285433-ehnu83qe author = Sun, Hongliu title = Detection of Cytomegalovirus Antibodies Using a Biosensor Based on Imaging Ellipsometry date = 2015-08-21 keywords = BIE; CMV; CMV-3A summary = doi = 10.1371/journal.pone.0136253 id = cord-001079-v01vwu00 author = Thoden, J. title = Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066) date = 2013-09-14 keywords = AIDS; CD4; CMV; HIV; art summary = doi = 10.1007/s15010-013-0504-1 id = cord-006393-jcj9nqfu author = Tutschka, Peter J. title = The use of immunoglobulin in bone marrow transplantation date = 1990 keywords = CMV; IVIG summary = doi = 10.1007/bf00918696 id = cord-004591-2hchnlwb author = Wicker, S. title = Seroprävalenz von Antikörpern gegen schwangerschaftsrelevante virale Infektionserreger bei Mitarbeiterinnen im Gesundheitswesen date = 2012-07-25 keywords = B19; CMV; Deutschland; und summary = In den vergangenen Jahren sind in Deutschland wiederholt behördliche Be schäftigungsverbote für schwangere Mit arbeiterinnen ausgesprochen worden, so fern diese in der Kinderbetreuung oder im Gesundheitswesen tätig und gegenüber schwangerschaftsrelevanten Infektionen (z. Im Hinblick auf eine potenzielle Infek tionsgefährdung dürfen nach § 4 Abs. 2 Nr. 6 des MuSchG werdende Mütter nicht "mit Arbeiten, bei denen sie infol ge ihrer Schwangerschaft in besonderem Maße der Gefahr, an einer Berufskrank heit zu erkranken, ausgesetzt sind oder bei denen durch das Risiko der Entste hung einer Berufskrankheit eine erhöh te Gefährdung für die werdende Mutter oder eine Gefahr für die Leibesfrucht be steht" beschäftigt werden. Healthcare workers · Maternity protection law · Pregnancy · Occupationally acquired infections gezeigt werden, dass Patienten und medi zinisches Personal sowohl Auslöser von Infektionsketten sein als auch an solchen Infektionen erkranken und versterben können [25] . Occupational risk of human cytomegalovirus and parvovirus B19 infection in female day care personnel in the Netherlands: a study based on seroprevalence Occupational risk for primary cytomegalovirus infection among pediatric health-care workers doi = 10.1007/s00103-012-1509-0 id = cord-103297-4stnx8dw author = Widrich, Michael title = Modern Hopfield Networks and Attention for Immune Repertoire Classification date = 2020-08-17 keywords = CMV; CNN; Hopfield; LSTM; MIL; sequence summary = In this work, we present our novel method DeepRC that integrates transformer-like attention, or equivalently modern Hopfield networks, into deep learning architectures for massive MIL such as immune repertoire classification. DeepRC sets out to avoid the above-mentioned constraints of current methods by (a) applying transformer-like attention-pooling instead of max-pooling and learning a classifier on the repertoire rather than on the sequence-representation, (b) pooling learned representations rather than predictions, and (c) using less rigid feature extractors, such as 1D convolutions or LSTMs. In this work, we contribute the following: We demonstrate that continuous generalizations of binary modern Hopfield-networks (Krotov & Hopfield, 2016 Demircigil et al., 2017) have an update rule that is known as the attention mechanisms in the transformer. We evaluate the predictive performance of DeepRC and other machine learning approaches for the classification of immune repertoires in a large comparative study (Section "Experimental Results") Exponential storage capacity of continuous state modern Hopfield networks with transformer attention as update rule doi = 10.1101/2020.04.12.038158 id = cord-006713-io9yp1y2 author = Wrede, C. E. title = Intensivmedizinische Betreuung von Patienten nach Stammzelltransplantation date = 2007 keywords = CMV; Komplikationen; Patienten; Phase; SZT; Therapie; der; die summary = Auf der anderen Seite haben diese Entwicklungen aber auch dazu geführt, dass sich das Spektrum der zur intensivmedizinischen Behandlung führenden Komplikationen verändert hat: Sie treten heute weniger in der Akutphase im ersten Monat nach Transplantation, sondern häufiger im weiteren Verlauf Monate und Jahre nach SZT bei Auftreten der GvHD oder nach erneuter adoptiver Zelltherapie mit Retransplantation auf. Während in der neutropenischen Pre-engraftment Phase die neutropenische Enterocolitis (siehe Kapitel Infektionen nach Stammzelltransplantation) im Vordergund steht, stellen vor allem bei allogener Transplantation nach dem Engraftment Enteritiden eine häufige Komplikation dar: Hier ist die exakte Erregerdiagnose wichtig, neben Clostridium difficile können eine Vielzahl viraler Erreger (CMV, HHV6, VZV, Adenovirus, aber auch typische Enteroviren wie Rotaviren und Noroviren) zu schweren und lang anhaltenden Enteritiden führen. Eine adäquate Diagnostik und Therapie von Komplikationen nach SZT ist für die intensivmedizinische Behandlung dieser Patienten essentiell, und kann zu einer Verbesserung der Prognose führen. doi = 10.1007/s00390-007-0774-x id = cord-011197-bmigh2rs author = Yener, Nazik title = Airway Pressure Release Ventilation as a Rescue Therapy in Pediatric Acute Respiratory Distress Syndrome date = 2020-03-03 keywords = APRV; ARDS; CMV summary = doi = 10.1007/s12098-020-03235-w id = cord-016990-ot1wi3xi author = Zaki, Sherif R. title = Viral Infections of the Lung date = 2008 keywords = CMV; Fig; HSV; Nipah; SARS; cell; human; infection; pneumonia; respiratory; virus summary = 105, [181] [182] [183] [184] [185] [186] [187] [188] [189] [190] [191] The pathology is more prominent in larger bronchi, and inflammation may vary in intensity in individual patients, Viral inclusions cannot be identified by light microscopy (Fig, 11 .8D), Secondary bacterial infections with organisms such as Streptococcus pneumoniae (group A streptococcus [GAS]), Staphylococcus aureus, and Haemophilus influenzae may occur as a complication in about 50% to 75% of fatal cases and make it difficult to recognize the pathologic changes associated with the primary viral infec-445 tion ,190,192,193 The histopathologic features in other organs may include myocarditis, cerebral edema, rhabdomyolysis, and hemophagocytosis (Figs, 11.8H and 11.9E,F), Immunohistochemistry and ISH assays demonstrate that viral antigens and nucleic acids are usually sparse and are primarily seen in the bronchioepithelial cells of larger bronchioles (Figs. doi = 10.1007/978-0-387-68792-6_11 id = cord-263276-keyu60in author = Zhou, Weimin title = Prevalence of Herpes and Respiratory Viruses in Induced Sputum among Hospitalized Children with Non Typical Bacterial Community-Acquired Pneumonia date = 2013-11-18 keywords = CMV; RSV; cap summary = doi = 10.1371/journal.pone.0079477 id = cord-004675-n8mlxe7p author = nan title = 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2019-02-26 keywords = ADA; CD3; CD4; CD8; CGD; CMV; CVID; EBV; HLH; HSCT; IFN; IVIG; PCR; PID; PIDD; RAG1; SCID; TCL; age; case; cell; disease; dna; dock8; infection; mutation; patient; report; result; year summary = However, the mean infusion rate per site was similar between patients aged <18 years ( XMEN disease (X-linked Immunodeficency with Magnesium defect, Epstein-Barr virus infection and Neoplasia) is a primary immune deficiency caused by mutations in MAGT1 and characterized by chronic infection with Epstein-Barr virus (EBV), EBV-driven lymphoma, CD4 T-cell lymphopenia, and dysgammaglobulinemia. We present the case of a 1-year old Hispanic infant with a pathogenic variant in MAGT1 gene that clinically manifested with early Pneumocystis jirovecii and cytomegalovirus (CMV) interstitial pneumonia, and EBV chronic infection with good response to intravenous immunoglobulins supplementation without hematopoietic stem cell transplantation or gene therapy. Chief, Laboratory of Clinical Immunology and Microbiology, IDGS, DIR, NIAID, NIH, Bethesda, MD, USA Hypomorphic Recombination Activating Gene 1 (RAG1) mutations result in residual T-and B-cell development in both humans and mice and have been found in patients presenting with delayed-onset combined immune deficiency with granulomas and/or autoimmunity (CID-G/AI). doi = 10.1007/s10875-019-00597-5 id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 keywords = AML; ASCT; ATG; BMT; CD19; CD34; CD4; CD8; CMV; CSF; DFS; DLI; EBMT; EBV; ECP; GVHD; HCT; HLA; HSCT; Hodgkin; Hospital; III; January; MDS; MRD; MSD; NHL; NRM; PBSC; PCR; PFS; PNH; RIC; TBI; TMA; TRM; University; VOD; background; car; cell; conclusion; day; disease; donor; figure; graft; group; high; median; method; mud; patient; result; transplantation summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. doi = 10.1038/s41409-019-0559-4 id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 keywords = AML; ASCT; ATG; BEAM; CD34; CD4; CD8; CMV; CSF; DFS; DLI; Department; EBV; ECP; GVHD; HCT; HLA; HSCT; Hematology; Hodgkin; Hospital; III; January; MDS; MRD; MSC; NHL; NRM; PBSC; PCR; PFS; RIC; SOS; TBI; TRM; Table; University; VOD; cell; day; figure; patient; transplantation summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . doi = 10.1038/bmt.2017.134 id = cord-005478-5iu38pr6 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date = 2019-07-03 keywords = AML; ATG; CMV; EBMT; GVHD; HCT; HLA; HSCT; MRD; NRM; RIC; VOD; background; car; cell; day; figure; patient summary = There were some differences among groups: patients in group-1 were younger (median age 46 years, p< 0.02) were transplanted in more recent year (2015, p< 0.001), received more frequently a regimen based on TBF (thiotepa, fludarabine and busulfan) (83%, p< 0.001) and bone marrow (BM) as source of stem cells (77%, p< 0.001), with no ATG (100%, p< 0.001). Clinical Trial Registry: NCT01217723 Disclosure: None of the Authors have any conflicts of interest to declare O105 Immune reconstitution -based score at diagnosis of CGVHD predicts GVHD severity and overall-survival: A novel prognostication tool for GVHD treatment tailoring Background: Allogeneic stem cell transplantation (HSCT) survivors are at a relevant risk of developing chronic GvHD (cGvHD), which importantly affects quality of life and increases morbidity and mortality. doi = 10.1038/s41409-019-0562-9 id = cord-005480-yg7salqt author = nan title = Oral Sessions and Working Party date = 2008-03-26 keywords = AML; ASCT; CD8; CMV; EBMT; GVHD; HCT; HLA; HSCT; MSC; NRM; RIC; TBI; TRM; cell; patient summary = Standard NIH or Eurolupus cyclophosphamide (CY) protocols and mycophenolate Mofetil (MMF) as induction therapy in severe BILAG A SLE is still associated with 20 % failure, 50% relapse and 10% to 15 % death at 10 years In the absence of a single standard treatment worldwide for refractory SLE, phase I-II studies analysed the use of: a) rituximab (anti CD20 mAb) in more than 1 000 patients showing complete to partial early response around 100% with relapse in 50 to 60% of the cases; b) autologous Hematopoietic Stem Cell Transplantation (HSCT) since 1997 under the auspices of the joined EBMT-EULAR working party, reporting durable remission with reduced or no immunosuppressive drug requirement in 66%, one-third of whom later relapsed to some degree with a 74 ± 7% (n= 62/79) overall survival at 5 years for SLE among the 863 HSCT procedures registered: in 2007 in the EBMT data base. doi = 10.1038/bmt.2008.30 id = cord-005487-vac061r8 author = nan title = Physicians Abstracts: EBMT 2010 date = 2010-04-07 keywords = AML; ASCT; CD34; CD8; CMV; CR1; EBMT; GVHD; HLA; HSCT; NRM; RIC; TBI; cell; patient summary = We retrospectively analyzed 1257 patients (pts), 755 children (age≤18) and 502 adults, receiving fi rst single (n = 1080) or double UCBT (n = 177) in EBMT centers, between 1995 and 2009 , for malignant and non-malignant diseases, who survived at least 100 days from transplantation with neutrophils recovery and without relapse or autologous reconstitution. Prochymal® improves response rates in patients with steroid-refractory acute graft-versus-host disease involving the liver and gut: results of a randomized, placebo-controlled, multicentre phase III trial in GvHD P.J. Martin (1) , J.P. Uberti (2) Background and methods: Steroid-refractory acute GVHD (SR-GVHD) remains a signifi cant and life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). A. Nagler (1) Background: Allogeneic transplantation of hematopoietic stem cells (allo-SCT) from an HLA-matched related (MRD) or unrelated donor (URD) is a curative option for patients (pts) with high-risk hematological disease (HRHD). doi = 10.1038/bmt.2010.40 id = cord-006466-e1phpqes author = nan title = 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2018-04-23 keywords = ADA; Background; CD3; CD4; CD8; CGD; CMV; CTLA4; CVID; EBV; GVHD; HSCT; IGRT; IVIG; Immunology; Introduction; PID; SCID; TREC; cell; conclusion; disease; dna; hct; infection; method; mutation; patient; result summary = Whole exome sequencing revealed a heterozygous mutation, previously reported (c.1425+1G>T) Conclusions: In summary, this report emphasizes the suspicion of a combined immunodeficiency in the presence of multiple abscesses by Mycoplasma, the usefulness of rDNA 16s in order to achieve proper Objectives: We describe a 15-year-old male patient with novel heterozygous mutation of EP300 gene; his first manifestations were initially characterized by infections, cytopenia and hypogammaglobulinemia suggesting a Common Variable Immunodeficiency (CVID), but later on, persisting lymphopenia was suggestive of a combined immunodeficiency. Conclusions: Close monitoring of immune function in early life for patients with CHH and CID as well as the availability of suitable donors assists in determining management, including HSCT Introduction/Background: Leukocyte Adhesion Deficiency (LAD) represents a group of distinct inherited disorders, which inhibit the normal extravasation of neutrophils and their recruitment to sites of infection or inflammation. doi = 10.1007/s10875-018-0485-z id = cord-006856-b1w25ob5 author = nan title = 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date = 2005 keywords = CMV; HBV; HCV; HSCT; PBSC; Patienten; cell; day; die; donor; graft; patient; recipient; transplantation summary = Egr-1 and hypoxia-inducible factor-1 (HIF-1) gene expression was examined in left ventricular biopsies of explanted failing hearts in 28 ICM and 42 DCM patients, as well as in 12 donor grafts before reperfusion (control), at 10, 30, 60 minutes after reperfusion, and at 1, 2, 3, 4, 6, 12 posttransplant weeks, using real-time RT-PCR. The risk of transplant-related mortality (TRM) due to graft-versushost disease (GvHD) is higher in male recipients of female stem cells compared with female patients receiving a graft from a female donor. We therefore analyzed a single-center cohort of 72 high-risk patients transplanted with a related or unrelated stem cell graft after nonmyeloablative conditioning for outcome (acute and chronic GvHD, TRM, relapse, and survival). Four patients between the age of 34 and 44 years underwent allogeneic peripheral blood stem cell (PBSC) transplantation (SCT) from HLA-identical sibling or unrelated donors at our institution. doi = 10.1007/s10353-005-0216-6 id = cord-009567-osstpum6 author = nan title = Abstracts Oral date = 2008-04-23 keywords = AMR; BALB; CD25; CD4; CD8; CMV; CNI; DSA; GFR; Group; HCV; HLA; IFN; IL-6; IRI; MELD; MHC; MMF; OLT; SRL; TAC; TLR4; Treg; University; cell; foxp3; graft; kidney; patient; recipient; result; transplant; transplantation summary = Introduction: Previously, it has been demonstrated that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during cardiac rejection, suggesting infiltration of regulatory T cells in the transplanted organ during an allogeneic response. Efficacy and safety parameters assessed at follow-up included: acute rejection; patient and graft survival; renal function, vital signs, basic lab results and immunosuppressive regimen for the patients 10 years after completion of the original study. We analyzed, for the first time, the expression of TLR4 in PBMC from kidney recipients with contrasted situations: operational tolerance and chronic immune-mediated rejection (Banff 2005), compared to patients with normal histology and stable graft function, non transplant patients with renal failure and healthy volunteers. doi = 10.1111/j.1600-6143.2008.02254.x id = cord-014462-11ggaqf1 author = nan title = Abstracts of the Papers Presented in the XIX National Conference of Indian Virological Society, “Recent Trends in Viral Disease Problems and Management”, on 18–20 March, 2010, at S.V. University, Tirupati, Andhra Pradesh date = 2011-04-21 keywords = BTV; CMV; CTV; ELISA; India; PCR; Pradesh; RNA; RTBV; disease; dna; gene; isolate; plant; protein; sequence; study; vaccine; virus summary = Molecular diagnosis based on reverse transcription (RT)-PCR s.a. one step or nested PCR, nucleic acid sequence based amplification (NASBA), or real time RT-PCR, has gradually replaced the virus isolation method as the new standard for the detection of dengue virus in acute phase serum samples. Non-genetic methods of management of these diseases include quarantine measures, eradication of infected plants and weed hosts, crop rotation, use of certified virus-free seed or planting stock and use of pesticides to control insect vector populations implicated in transmission of viruses. The results of this study indicate that NS1 antigen based ELISA test can be an useful tool to detect the dengue virus infection in patients during the early acute phase of disease since appearance of IgM antibodies usually occur after fifth day of the infection. The studies showed high level of expression in case of constructed vector as compared to infected virus for the specific protein. doi = 10.1007/s13337-011-0027-2 id = cord-015365-iqdi99pd author = nan title = 25th Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics Graz, October 19–21, 2011 date = 2011 keywords = ATG; BMT; Background; CD4; CMV; Patienten; SCT; Therapie; cell; der; die; graft; method; mit; patient; recipient; result; transplantation; und; von summary = Retrospective study to test ferritin serum levels as biomarker for graft-versus-host disease-associated non-infectious inflammatory reaction in 117 children after hematopoietic stem cell transplantation Background. One hundred seventy-eight patients (85 males, 93 females) with a median age of 40 years alive on day þ 100 after HCT with myeloablative (n ¼ 110) or reduced-intensity (n ¼ 68) conditioning and a related (n ¼ 37) or unrelated (n ¼ 141) stem cell donor were enrolled into the study. Using a non-myeloablative conditioning regimen followed by donor bone marrow (DBM) transplantation, we observed successful production of mixed chimerism in non-human primate renal allograft recipients, followed by normal kidney function with no evidence of chronic rejection for periods as long as thirteen years after discontinuing all I.S. In vitro studies of these recipients as well as of humans suggest that both central (clonal deletion) and peripheral (regulatory cells) mechanisms are involved. doi = 10.1007/s10353-011-0041-z id = cord-015389-vwgai4k9 author = nan title = Publication only date = 2009-03-25 keywords = AML; CD34; CMV; CSF; GVHD; HLA; HSCT; cell; day; median; patient summary = This study evaluates the safety of this approach, in terms of infusion-related toxicity and hematopoietic reconstitution, in 385 consecutive autologous transplantations performed from 4/97 to 9/08 in 348 patients (median age 46; underlying disease: lymphoma in 178, myeloma in 131, acute leukaemia in 17, breast cancer in 22). Patients and methods: Eight pts after allogeneic hematopoetic stem cell transplantation (HSCT) underwent MSCs infusions (median age of pts was 11 years, male/female: 6/2) between 2006 and 2009. Akiyama Tokyo Metropolitan Komagome Hospital (Tokyo, JP) Acute graft-versus-host disease (GVHD) is one of the major factors that have infl uence on the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Material and methods: during a 8 years period we have performed 144 stem cells transplantation in 134 patients with different hematological malignancies(AML: 74; ALL: 6; CML: 7; CLL: 1, NHL: 13; Hodgkin Diseases: 16; Multiple myelomas: 24; Aplastic anaemia: 1;Myelofi brosis:1 Ewing Sarcoma: 1; Male:78 Female 66. doi = 10.1038/bmt.2009.50 id = cord-016998-6n662amh author = nan title = Nierentransplantation date = 2007 keywords = Abstoßung; CMV; Ciclosporin; HLA; Jahren; Patienten; Transplantation; der; die; und; von summary = doi = 10.1007/978-3-540-48556-8_13 id = cord-022888-dnsdg04n author = nan title = Poster Sessions date = 2009-08-19 keywords = APC; BCR; CD14; CD4; CD8; CMV; CTL; EBV; ELISA; Germany; HCV; HIV; HLA; IBD; IFN; IL-10; IL-2; IL-4; IL-6; Immunology; Institute; LPS; MHC; NKT; PCR; RNA; SLE; TCR; TGF; TLR; TLR4; TNF; University; antigen; cell; dna; expression; immune; mouse; patient; protein; response; result; study; th1; th2 summary = Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. doi = 10.1002/eji.200990224 id = cord-313474-1gux1gsi author = nan title = Physicians Abstracts date = 2015-03-20 keywords = AML; ATG; CD34; CMV; GVHD; HCT; HLA; HSCT; Interest; NRM; RIC; cell; patient summary = Materials (or patients) and methods: We performed a multicenter, multinational, open-label, randomized study comparing anti-lymphocyte globulin (ATG-Fresenius s ) 10 mg/kg on day -3, -2 and -1 with no ATG in patients with AML (n ¼ 110) or ALL (n ¼ 45) in 1 st complete remission (CR; n ¼ 139) or 2 nd CR (n ¼ 16) who received peripheral blood stem cells from their HLA-identical sibling after standard TBI (12 Gy)/Ccclophosphamide (120 mg/kg) or busulfan (16 mg/ kg)/Cy (120 mg/kg) based myeloablative conditioning regimen. After allo-HSCT, detection of positive WT1 was followed by immunomodulatory therapeutic interventions according to the time from transplant, the presence of active graft-versus-host disease (GvHD) and the general clinical conditions: tapering and/or discontinuation of immunosuppressive drugs (IS), donor lymphocytes infusions (DLI), administration of hypomethylating agents. Introduction: Haploidentical hematopoietic stem cell transplantation(Haplo-HSCT)is feasible option for patients with acute leukemia(AL)at high risk of relapse who do not have HLA-matched related or unrelated donors. doi = 10.1038/bmt.2015.27 id = cord-340489-yo3cp5vs author = nan title = KAPITEL 13 Infektionskrankheiten date = 2008-12-31 keywords = AIDS; CMV; Erkrankung; Erreger; Fieber; HIV; Infektion; Jahren; Nachweis; Patienten; RNA; Substanzen; Symptome; Therapie; Viren; Virus; Zellen; auch; bei; der; des; die; durch; eine; ist; mit; oder; sind; und; von; werden summary = Die Wirksamkeit von BVDU bei VZV-Infektionen (Varizellen und Zoster) immunkompromittierter Patienten ist durchaus sehr gut und vergleichbar der von i.v. verabreichtem Aciclovir, jedoch fällt die Nutzen-Risiko-Betrachtung insgesamt auch bei VZV-Therapie zu Gunsten von Aciclovir aus, da BVDU eher mutagen zu sein scheint und nicht zusammen mit 5-Fluorouracil (Zytostatikum) gegeben werden darf. In klinischen Studien konnte durch Anwendung von ACV bei EBV-Infektionen auch die Virusausscheidung deutlich vermindert werden, ein wesentlicher Einfluss auf den Krankheitsverlauf ließ sich nicht erreichen. Typisch für viele opportunistische Erreger ist, dass sie weit verbreitet sind und nach einer Primärinfektion, die bereits vor der HIV-Infektion stattfindet, zu latenten Infektionen führen. Die Prophylaxe von Infektionen bereits vor deren erstem Auftreten (Primärprophylaxe) oder nach der ersten Episode (Sekundärprophylaxe) ist weiterhin eine wichtige Aufgabe bei der Betreuung HIV-positiver Patienten, auch wenn opportunistische Infektionen durch die antiretrovirale Therapie insgesamt seltener geworden sind. doi = 10.1016/b978-3-437-42831-9.10013-0 id = cord-003376-2qi4aibx author = van de Groep, Kirsten title = Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date = 2018-12-18 keywords = CMV; ICU; patient summary = title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study Cytomegalovirus (CMV) reactivation is observed in 14-41% of intensive care unit (ICU) patients without known prior immune deficiency [1] [2] [3] and is associated with increased morbidity and mortality [4] [5] [6] . Therefore, this longitudinal study aimed to investigate whether the temporal course of seven host response biomarkers, including both pro-and anti-inflammatory cytokines, in previously immunocompetent ICU patients with sepsis differs between patients with and without CMV reactivation. Time trends of various markers within patients were described by symmetric percentage differences relative to their levels 2 days prior to CMV viremia onset (Fig. 2 for primary comparison, Additional file 1: Figure S1 for secondary comparison). We performed an explorative study to compare time trends of host response biomarkers in patients with reactivation that were matched to non-reactivating control patients who were either seropositive or seronegative for CMV. doi = 10.1186/s13054-018-2261-0 id = cord-016255-kkko1xne author = van der Meer, J.T.M. title = 14 Intravasale infecties en sepsis date = 2011 keywords = CD4; CMV; EBV; bij; een; het; hiv; infectie; van summary = doi = 10.1007/978-90-313-7944-6_14