id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323940-ubazgvov	Cafiero, Concetta	Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease	2020-10-13		.txt	text/plain	7359	408	34	Recently, pharmacogenomics (the effects of a single genetic marker) and pharmacogenetics (the collective influence of variability across the genome to modulate an individual's drug response) have received great attention for their abilities to provide a new way to select drugs for personalized therapy (optimal dosing for maximizing drug efficacy or minimizing the risk of toxicity). 35 Search terms were "Covid-19", "novel coronavirus", "SARS-CoV2", "pharmacogenetics", "treatment/s", "adverse side effects", "therapy", "lung", "ocular", "pulmonary infection", "drugs", "drug response", "virus", "candidate drugs", "potential inhibitors", "protease inhibitors", "personalized medicine", "individual therapy", "pneumonia", "ACE", "heparin", "vasculitis", "conjunctivitis", "rhinitis", "hematological complication" and "main metabolic routes", either alone or in combination. Drugs in use as routine therapy or in clinical trials for Covid-19 include steroids and antiviral and biological humanized neutralizing antibodies against some proinflammatory cytokines, such as IL1, IL6, IFN, and TNFα, in addition to supportive measures and symptomatic treatment, according to the severity of the disease.	./cache/cord-323940-ubazgvov.txt	./txt/cord-323940-ubazgvov.txt