id author title date pages extension mime words sentences flesch summary cache txt cord-000317-pixbry0c Eggo, Rosalind M. Spatial dynamics of the 1918 influenza pandemic in England, Wales and the United States 2011-02-06 .txt text/plain 6381 324 52 To better characterize the spread of the 1918 major wave, we fitted a range of city-to-city transmission models to mortality data collected for 246 population centres in England and Wales and 47 cities in the US. Using a gravity model for city-to-city contacts, we explored the effect of population size and distance on the spread of disease and tested assumptions regarding density dependence in connectivity between cities. We employed Bayesian Markov Chain Monte Carlo methods to estimate parameters of the model for population, infectivity, distance and density dependence. For England and Wales, a model that estimated the degree of density dependence in connectivity between cities was preferable by deviance information criterion comparison. The low kernel power parameter estimates we have found in both England and Wales and the US suggests that long-distance interactions were important in spreading influenza between distant cities in both countries. ./cache/cord-000317-pixbry0c.txt ./txt/cord-000317-pixbry0c.txt