id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-323742-rt0g0ufe	Carter, Michael J.	Assessment of an Antibody-in-Lymphocyte Supernatant Assay for the Etiological Diagnosis of Pneumococcal Pneumonia in Children	2020-01-17		.txt	text/plain	7421	318	39	Acute IgG ALS to pneumococcal proteins discriminated between pneumococcal pneumonia and non-pneumococcal pneumonia in children enrolled to the study with good sensitivity and specificity, with AUROC curve ranging from 0.60 (95% CI 0.42-0.79) for Ply, to 0.85 (95% CI 0.75-0.94) for CbpA, using thresholds derived from the Youden Index (Table 2) . Among children with non-pneumococcal pneumonia (i.e., not "confounded" by definite pneumococcal or probable pneumococcal or probable bacterial or unknown pneumonia), those with NP carriage of pneumococci had higher acute IgG ALS to all five pneumococcal proteins than those without NP carriage (Wilcoxon rank sum tests; CbpA, p < 0.001; PcsB, p < 0.001; PhtD, p < 0.001; Ply, p < 0.001; StkpC, p < 0.001; Figure 7) . Among children ≥2 years of age with non-pneumococcal pneumonia, there were no significant differences in acute IgG ALS to any pneumococcal protein detected between those with (n = 19) and without (n = 49) NP carriage of pneumococci (Wilcoxon rank sum tests, p > 0.5 for all comparisons, Figure S4 ).	./cache/cord-323742-rt0g0ufe.txt	./txt/cord-323742-rt0g0ufe.txt