id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310534-ng6321hh	Kaushik, Ashlesha	COVID-19 in Children: Clinical Approach and Management- Correspondence	2020-07-08		.txt	text/plain	1385	84	45	We would like to commend the authors for a timely and succinct article on approach to management of pediatric COVID-19, providing essential and practical guidance to clinicians, and would like to comment on the management of COVID-19 in light of recent evidence, available studies and guidelines. The therapeutic approach for managing critically ill patients with Acute respiratory distress syndrome (ARDS)/ respiratory failure centers around lung protection with low tidal volumes, high positive end-expiratory pressures and fluid restriction. A recent multicenter expert pediatric guidance panel has recommended Remdesivir as the preferred antiviral agent in children if available [3] . HCQS has been shown to be effective against SARS CoV-2 in in-vitro studies, considered relatively safe in children, and is also suggested by authors in the management approach. But in regions where Remdesivir is not available, either Lopinavir/Ritonavir or Hydroxychloroquine (or Chloroquine) maybe used in children with severe disease (preferably as a part of clinical trial).	./cache/cord-310534-ng6321hh.txt	./txt/cord-310534-ng6321hh.txt