cord-000091-1qo1krxv	2005	
cord-001835-0s7ok4uw	2015	Altogether, these results indicate that, although PHDs might be more selective for HIF as a substrate as it was initially thought, the enzymatic activity of the prolyl hydroxylases is possibly influenced by a number of other proteins that can directly bind to PHDs. Non-natural aminoacids via the MIO-enzyme toolkit Alina Filip 1 , Judith H Bartha-V ari 1 , Gergely B an oczy 2 , L aszl o Poppe 2 , Csaba Paizs 1 , Florin-Dan Irimie 1 1 Biocatalysis and Biotransformation Research Group, Department of Chemistry, UBB, 2 Department of Organic Chemistry and Technology An attractive enzymatic route to enantiomerically pure to the highly valuable a-or b-aromatic amino acids involves the use of aromatic ammonia lyases (ALs) and aminomutases (AMs). Continuing our studies of the effect of like-charged residues on protein-folding mechanisms, in this work, we investigated, by means of NMR spectroscopy and molecular-dynamics simulations, two short fragments of the human Pin1 WW domain [hPin1(14-24); hPin1(15-23)] and one single point mutation system derived from hPin1(14-24) in which the original charged residues were replaced with non-polar alanine residues.
cord-004584-bcw90f5b	2011	Our goals are two-fold: (1) to monitor conformational changes in each domain upon its binding to specific ligands and then to correlate the observed changes with structural differences between the CRDs and (2) to investigate the interaction between the CRDs and lipid model membranes. Cholesterol-assisted lipid and protein interactions such as the integration into lipid nanodomains are considered to play a functional part in a whole range of membrane-associated processes, but their direct and non-invasive observation in living cells is impeded by the resolution limit of [200nm of a conventional far-field optical microscope. Therefore, to investigate the dynamic and complex membrane lateral organization in living cells, we have developed an original approach based on molecule diffusion measurements performed by fluorescence correlation spectroscopy at different spatial scales (spot variable FCS, svFCS) (1).
cord-004935-z86x3hnu	2012	
cord-005049-itkj5o5o	2015	In the climate change context, such societal teleconnections add a layer of risk that is currently neither fully appreciated in most impacts or vulnerability assessments nor in on-the-ground adaptation planning. This paper introduces a simple but systematic way to conceptualize societal teleconnections and then highlights and explores eight unique but interrelated types of societal teleconnections with selected examples: (1) trade and economic exchange, (2) insurance and reinsurance, (3) energy systems, (4) food systems; (5) human health, (6) population migration, (7) communication, and (8) strategic alliances and military interactions. This example is now widely cited by the private sector and has spurred several Fortune 500 firms to begin to assess supply chain vulnerabilities-one possible societal teleconnection-through the lens of climate change (Gledhill et al. In summary, societal teleconnections are important considerations for locally-based climate change vulnerability assessments and adaptation planning in the public and private sector.
cord-005080-r01ii1bu	2005	
cord-005677-ijrghpco	2019	
cord-005814-ak5pq312	1995	Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life.
cord-011011-jxymy4e4	2020	Six categories of drivers to change were identified: availability of new knowledge or technology; guidelines or regulations from outside the unit; need to standardize practices; participation in research; occurrence of adverse events; and wish to improve care. 13 We carried out a qualitative study with physicians and nurses to explore how clinical or organizational innovations are introduced and implemented in neonatal intensive care units (NICUs), a setting characterized by extreme patient fragility, complex technological environment, highly specialized multidisciplinary personnel. (Physician/Germany/39) In one case only the reported research, a randomized clinical trial to identify the lowest baby''s weight for safe transition from incubator to open cot, was designed by the informant and carried out within the unit itself: Nevertheless, when the change involves, as in this case, organizational modifications requiring compliance by the whole team and the parents, implementation can still be challenging:
cord-025374-504mfiie	2020	Convened by French President Emmanuel Macron to mark the COP21''s second anniversary, the Summit provided business and NGO leaders, representatives from international organisations and national and multilateral development banks, heads of state and government, philanthropists and mayors with an opportunity to both reassert their commitment to the Paris agreement and to announce new measures for its implementation. As illustrated by the examples above, the post-Paris process conveys a central role to the emission of ''signals'' and the creation of ''momentum'' for climate action, through carefully orchestrated global moments such as the One Planet Summit and Climate Action Summits and highly publicised private initiatives like #WeReStillIn. In other words, in this new governance, performances, symbols and narratives appear to be just as important as the production of rules, institutions and instruments.
cord-026881-57mx3thr	2020	
cord-030279-pv770doe	2016	From ''dual-use life science research of concern'' through the rise of amateur biology to the advent of personalised medicine, the chapter exposes the limitations of the existing governance mechanisms in accommodating the multifaceted ethical, social, security, and legal concerns arising from cutting-edge scientific and technological developments. Indeed, rapid advances in the field have produced a knowledge base and set of tools and techniques that enable biological processes to be understood, manipulated and controlled to an extent never possible before 5 ; they have found various applications in numerous spheres of life, generating enormous benefits and offering bright prospects for human betterment; and they have come to be regarded as a key driver of economic development with potential to close the gap between resource-rich and resource-poor countries.
cord-030421-8eu9zlba	2020	
cord-030909-6if3qquj	2020	Based on these points, it becomes clear that a green recovery plan with resources directed towards achieving the combined objective of both providing the necessary economic stimuli for recovery and also promoting the transition to a low-carbon economy and adaptation to climate change along with investment in natural capital and increase in comprehensive savings could be a feasible and efficient plan. The current global greenhouse gas (GHG) emissions trajectory indicates that the world is likely to experience catastrophic consequences due to climate change, unless swift action is taken towards funding green solutions and the defunding of fossil fuel activities ( Given the ambition of the European Union to become a net zero-carbon economy by 2050 and the numerous calls to avoid the bailout and stimulus packages towards fossil fuel companies , we examine whether the features of the European Central Bank''s (ECB) €1350 billion Pandemic Emergency Purchase Programme (PEPP) encourages the resilience of the incumbent fossil fuel sector, or whether it promotes the growth of the emerging low-carbon energy sector during the COVID-19 pandemic and beyond.
cord-030984-2mqn4ihm	2020	As with climate vulnerabilities and public and environmental health (Faber, 2015; Gebreyes and Theodory, 2018; Klinenberg, 2002; Solomon et al., 2016) , emerging accounts of the COVID-19 pandemic indicate that communities facing elevated threats to their lives and livelihoods are those who are elderly, experience chronic medical conditions, and are socially, politically and economically marginalised (CDC, 2020; Manderson and Levine, 2020; Raffaetà, 2020) . Building on his earlier work (Beck, [1986] 2005), Beck''s (2009) "world risk society" thesis highlights the growing prominence of large-scale technological and industrial processes in modernity that has given rise to unstable global financial markets and climate change and associated threats for the broader public. For example, political and economic actors and institutions across the world are refashioning previous capital accumulation strategies and their spatial and ecological "fixes" through financial instruments and market-based mechanisms that seek to mitigate against and adapt people and places to environmental disasters, terrorist threats and the climate crisis (Castree and Christophers, 2015; Gotham and Greenberg, 2014; Knox-Hayes, 2013; Ouma et al., 2018) .
cord-104288-120uu4dh	2009	
cord-212813-yrca1hij	2020	In particular, we identify human agency, social-institutional network structures, different spatial and temporal scales and increased complexity as key distinctive features underlying social tipping processes. Following these distinctions, we present a definitional framework for identifying social tipping processes for sustainability, where under critical conditions, a small perturbation can induce non-linear systemic change, driven by positive feedback mechanisms and cascading network effects. We adopt this framework to understand potential social tipping dynamics in the European political system, where the FridaysForFuture movement (16) pushes the system towards criticality, generating the conditions for shifting climate policy regimes into a qualitatively different state. Accordingly, the European political system could constitute a potential ''social tipping element'', where as it nears critical conditions, a small change to the system or its broader environment could lead to large-scale macroscopic changes, affected by cascading network dynamics and positive feedback mechanisms.
cord-228935-0k18vtho	2020	
cord-242424-hp1ao99i	2020	The article covers electricity demand shift effects due to COVID-19 shutdowns in various European countries. In this paper, we analyse the change in electricity demand pattern in selected European countries caused by the COVID-19 shutdowns. Therefore, in order to recognize whether the change in the load is shutdown-, season-, or weather-driven we need a sophisticated demand model to disentangle the reduction effects. For exploiting the structural changes in the electricity demand due to the shutdown we apply a high-dimensional time series change-point models to the electricity log-load of each country. The baseline model contains mainly two types of components i) pattern-based time-varying coefficients and ii) autoregressive effects. Figure 5 presents the electricity demand in the other considered countries: Germany, France, Spain and Poland. The shutdowns introduced due to the COVID-19 pandemic have impacted significantly both the level of the electricity demand in Europe and its weekly pattern.
cord-260702-1ljyk8uw	2020	
cord-264348-n551lttt	2020	
cord-274189-mrrctuxt	2004	
cord-280582-iska6pt8	2020	This study assessed the self-reported changes in substance use among a young adult population during an ongoing respiratory disease pandemic with imposed social distancing. Due to the timing of our survey launch with the COVID-19 pandemic, we included one additional question to assess "Do you think your use of electronic vaping products, tobacco products, alcohol, or marijuana (any of these) changed (increased or decreased) since Coronavirus (COVID-19) outbreak?" If individuals answered "Yes," we then provided subsequent questions to assess the directionality of change of each product type as: "Which of the following products and to what direction this change happened?" with the response option of "Increase / Decrease" for each substance type. When analyzing within substance type groups (electronic vaping, marijuana, tobacco product, alcohol), we did not observe significant differences by report of loneliness, anxiety, or depression for changes in substance use direction (increased vs decreased usage). We also observed that the proportion of respondents reporting a change in their substance use patterns differed by age, self-reported anxiety and depression, and degrees of loneliness.
cord-291909-x0sfwqnk	2019	
cord-293365-z1h788sc	2019	71 Migrants may be at increased risk of communicable disease in their country of destination due to factors including lack of vaccination, low socioeconomic status and poor living conditions and limited access to health care (Table 3) . 72 Essential public health measures include ensuring adequate living conditions, access to health care in refugee camps, detention centres, screening for communicable diseases and assessment Offer serological screening and treatment (for those found to be positive) to all migrants from countries of high endemicity in sub-Saharan Africa and focal areas of transmission in Asia, South America and North Africa. [95] [96] [97] [98] More specifically, air travel can increase the risk of importation of pathogens from endemic areas into regions with competent mosquito vectors and suitable climatic and environmental conditions for vector-borne diseases. 102, 103 Responding to the public health challenges associated with travel and climate change requires robust national surveillance systems, including effective tracking of vector location and disease importation.
cord-294291-tnsubtjr	2020	
cord-294815-mhqe3xjz	2020	title: Analysis of the early Covid-19 epidemic curve in Germany by regression models with change points We apply the segmented regression model to time series of the estimated daily numbers of infections for Bavaria and Germany. Since the back propagation algorithm yields an estimate for the expected values of the number of daily infections and does so by inducing a smoothing effect, as a sensitivity analysis for the location of the breakpoints, we also apply the model to the time series of the daily number of disease onsets. In Figure 1 , the three different time series of daily cases (reported, disease onset and estimated infection date) are presented. For the Bavarian data on disease onset, the model with K = 4 change points gives the best result with an estimate of the over-dispersion parameter of 3.8, i.e., the variance of Y t is 3.8 times higher than the value of Var(Y t ) = E(Y t ) otherwise expected under the assumption of the Poisson regression model.
cord-295981-yak8839s	2020	It applies and modifies core components of Gramsci''s approach, building a neo-Gramscian theory of just transitions around concepts of ideology, hegemony, change agents and fundamental conditions. The objectives of this article are, firstly, to advance a neo-Gramscian theory of a just transition and, secondly, to apply it in aid of a better understanding of shifting development pathways to zero carbon and zero poverty (ZPZC). pointing to actors and transitions scholars themselves have identified gaps, including: "Social inequality, poverty and lack of access to modern services such as sanitation or education in low-income economies might be considered more important than global environmental rationales such as climate change" [15] . Applying neo-Gramscian theory, the explanatory model advanced here is that an alliance of change agents coalesces around an ideological elementthe just transitionand gains support of others, establishing a new hegemony, and is able to transform these fundamental conditions.
cord-299407-wuug8jjv	2020	OBJECTIVE: Better understand knowledge, attitudes and practices of pregnant women and mothers of infants around coronavirus disease 2019 (COVID-19). CONCLUSION: This study provides initial insight into the knowledge, attitudes and practices of pregnant and postpartum women during the COVID-19 pandemic. The 58-item survey included demographics, pandemic-related behaviors [16] , pregnancy, infant and self-care, access to healthcare, mental health, and financial stability [17] Participants reported changes in mental status related to the COVID-19 pandemic (n=94, 82.5%), including increased stress (n=72; 63.2%), increased anxious thoughts (n=57; 50.0%), changes in sleep patterns (n=54; 47.4%), reduced motivation (n=53; 46.5%), increased fearful thoughts (n=46; 40.4%), changes in appetite (n= 46; 40.4%), racing thoughts (n=41; 36.0%), difficulty in focus and concentration (n=42; 36.8%), depressed mood (n=33; 28.9%) and increased tearfulness (n=23; 20.2%). This exploratory study identified behavior changes of perinatal women specifically attributed to the COVID-19 pandemic.
cord-301745-cuatqy1u	2020	The current study investigated whether the psychological impact of COVID19-related circumstantial changes was moderated by introversion, based on outcome measures across psychosocial, cognitive, and affective domains. One hundred and fourteen individuals (64 USA residents) completed measures of introversion, and reported on the extent to which they experienced loneliness, anxiety, depression and cognitive impairments as a function of COVID19-related circumstantial changes. Additionally, the psychological impact of COVID19-related circumstantial changes (and mental health in general) has psychosocial, cognitive, and affective aspects, which in turn represent functional domains which may be differentially moderated by personality traits (Segel-Karpas and Lachman, 2018) . After controlling for age, gender, living condition and recent unemployment, higher introversion (higher Introversion Scale scores) uniquely predicted higher depression (PHQ-9) and anxiety (GAD-7) experienced as a function of COVID19-related circumstantial changes, β = 0.196, t = 2.12, p = 0.036 and β = 0.188, t = 2.02, p = 0.046, respectively.
cord-302848-a246wl7f	2013	Maintaining or increasing ecosystem services into the future will require integrating adaptation strategies (actions that help human and natural systems accommodate changes) and mitigation strategies (actions that reduce anthropogenic influences on climate) ( Figure 1 ). In this chapter, we provide an overview of what will likely be some of the most effective and most important mitigation and adaptation strategies for addressing changes to the climate system stemming from increased GHG emissions. We discuss various ways in which mitigation and adaptation strategies can help reduce the magnitude and the impacts of the changes we are likely to experience, as well as improve human health and directly or indirectly affect ecosystem functions and services. Restoring or protecting some semblance of the natural river flow conditions necessary to support ecosystem function (called environmental flows) into the future is one of the most important climate change adaptation strategies for flowing waters.
cord-303557-bbbq6ylr	2018	
cord-305903-qkoc68ky	2020	In particular, the process by which we let our assessment of facts be influenced by values, prior beliefs, policy preferences, and by how we feel about a source of information is variously called biased assimilation, hot cognition, or motivated reasoning. Climate denial is a case in point-public views have been influenced by ongoing campaigns to discredit the scientific consensus and block action, exploiting our cognitive shortcuts (Givens et al. How then did Trump''s election influence public views on climate change? They find that once Trump was in office and his views on climate, the environment, and government regulation were instantiated in policy actions, the effect was to some degree the opposite of what Hahnel et al. Both papers use the 2016 Presidential election as a natural experiment to examine the processes that can shift public views on climate change. Climate change views, energy policy support, and personal action in the Intermountain West: the anti-reflexivity effect
cord-308300-p9jyyt08	2020	
cord-320172-qw47pf9r	2000	In common with other changes induced in the digestive tract of rats and cynomolgus monkeys by the administration of recombinant human epidermal growth factor, the tongue showed squamous epithelial hyperplasia characterised by a uniform increase in the thickness of the squamous epithelium in both species (Breider et al., 1996; Reindel et al., 1996) . Detailed study of hypertrophy, protein synthesis, and intracellular cAMP activity in the salivary glands of rats treated for 10 days with isoprenaline (isoproterenol), a series of β-adrenergic receptor agonists and the phosphodiesterase inhibitors, theophylline and caffeine, showed that similar effects occurred with all agents although differences in the degree of hypertrophy, the nature of pro-tein and glycoprotein synthesis and Golgi membrane enzyme activity were recorded (Wells and Humphreys-Beher, 1985) . Studies in the rat have shown that diffuse atrophy of the gastric glands characterised by a decrease in the number and size of parietal, chief and mucous cells occurs transiently following truncal vagotomy but histological features return to normal by about 1 month after surgery (Nakamura, 1985) .
cord-320914-zf54jfol	2020	
cord-322527-m1ig1hii	2020	
cord-323621-cw54dfos	2020	The title of the session was Student Voices: Envisioning the Future of Health Sciences Education Across Different Healthcare Professions Worldwide. working with students and experts in the community should identify opportunities to integrate information about diverse patient groups into the medical curriculum. Paris Webb, D4 Student, Texas A&M University College of Dentistry, USA In response to the COVID-19 pandemic, many institutions were forced to switch from a traditional in-class lecture model to a virtual educational format. Specifically, the institution introduced several curricular changes to provide new educational approaches and assessments to prepare future dentists to excel in the evolving field of dentistry. These changes in healthcare education necessitate collaboration between students, educators, and institutions to ensure that the next generation of dental health professionals are well prepared to provide individualized patient care. To prepare the dental students of today for this new reality of the future, Radboud UMC Dental Faculty developed a Master Clinic program for 4-6th year students.
cord-326785-le2t1l8g	2005	
cord-327695-zab46s9n	2020	
cord-328655-55ebve2k	2011	We suggest that forecasts of climate-change impacts on disease can be improved by more interdisciplinary collaborations, better linking of data and models, addressing confounding variables and context dependencies, and applying metabolic theory to host–parasite systems with consideration of community-level interactions and functional traits. We suggest that forecasts of climate-change impacts on disease can be improved by more interdisciplinary collaborations, better linking of data and models, addressing confounding variables and context dependencies, and applying metabolic theory to host-parasite systems with consideration of community-level interactions and functional traits. Third, the emphasis of metabolic theory has been on effects of mean temperature, but changes in other climatic components, such as precipitation and climatic variability, also could impact species interactions (Figure 2 ), especially for parasites with life stages outside the host.
cord-328902-c91mthxv	2020	
cord-332313-9m2iozj3	2016	
cord-336743-udokbcki	2020	Setting the level of ventilator assist in everyday practice relies mostly on the clinical estimation of inspiratory effort, as indicated by the breathing pattern -tidal volume (VT) and respiratory rate (RR)-and clinical signs of respiratory distress (Boles et al., 2007; Hansen-Flaschen, 2000; Hess, 2001; Ray et al., 2006) . The aim of this study was to 1) characterize the responses of respiratory drive, respiratory effort, and breathing pattern to changing levels of ventilatory assist in critically ill patients and 2) assess if changes in respiratory rate may indicate changes in respiratory drive and effort. To this end, during proportional assist ventilation with adjustable gain factors (PAV+), noninvasive measurements of respiratory drive, effort (as indicated by inspiratory muscle pressure) were obtained at different levels of assist, using a validated prototype monitor (PVI) (Kondili et al., 2010; Younes et al., 2007) .
cord-338933-67e98ok3	2020	
cord-339374-2hxnez28	2020	
cord-343559-kjuc3nqa	2020	title: Short-Term Changes in Behaviors Resulting from COVID-19-Related Social Isolation and Their Influences on Mental Health in Ghana Findings indicate that reduced physical activity time and a change in sexual activity and smoking frequency are some short-term changes in behavior resulting from social isolation during the lockdown. We are, therefore, of the view that social isolation necessitated by a COVID-19-related lockdown would not only cause fear and panic in the short-term but could also lead to anxiety and consequently a decline in mental health in the general population. Our investigation was based on this primary research question: Do changes in behaviors due to COVID-19 social distancing measures have a significant influence on mental health? This study focused on possible short-term changes in behaviors resulting from COVID-19-related social isolation or fears. For the most part, changes in behaviors in the short-term attributable to COVID-19 social isolation were associated with lower mental health scores.
cord-345662-vm5btiue	2020	Based on a study of South Africa''s budget processes, it is concluded that change will only occur when four separate pre-conditions converge, namely a rapidly growing environmental problem capable of leading to civil unrest, a supportive and recently developed policy framework, decreasing techno-economic costs for its solution, and strong political support from an effective ministry or minister. Although there are several publications on green financing within South Africa, such as its broader challenges and necessary design features [23] and the role that public financial intermediaries have already played in the country''s energy transition [24] , there have been no specific studies on how to mobilise and reorient government expenditure for sustainability transitions, and particularly the decarbonisation of its energy sector.
cord-346050-ssv1arr1	2020	This creates an opportunity to explore the preliminary effects of this lockdown on crime trends in one of Canada''s major cities, with the intention of determining if the shift in opportunity structures have changed crime trends and to improve planning for safety and crime prevention for potential further outbreaks of the pandemic and future exceptional events. Opportunity theories, such as routine activities theory, would predict that during an exceptional event, crime rates will both increase and decrease depending on the crime type and the shift in opportunity structure (Leither et al., 2011) . Routine activity theory argues that in order for a crime event to occur, a suitable target, a motivated offender, and the lack of a capable guardian need to come together in time and space (Cohen & Felson, 1979) .
cord-346510-upyhirb7	2020	
cord-347126-hvrly37e	2020	
cord-350270-rcft3xfh	2020	title: Social scientific knowledge in times of crisis: What climate change can learn from coronavirus (and vice versa) Governments always have to weigh up different forms of knowledge and expertise, from scientific and technical knowledge to policy and political considerations. But in periods of crisis-when information is more uncertain, susceptible to rapid change and when more attention is given to decision-making processes-it becomes increasingly difficult to ensure the effectiveness of government interventions. Climate change too has seen mathematical modeling take a prime position in the search for authoritative knowledge in the context of deep uncertainty (Wynne, 2010) . Apart from offering inevitably uncertain predictions, mathematical models also obscure the social nature of the climate risk being faced (Wynne, 2010) . Social scientific knowledge deepens our understanding of how perceptions of risk, fear and trust impact on crisis mitigation. The underlying drivers of climate change are much more deeply rooted in global economic, technological, cultural and political structures than are those for COVID-19.
cord-351204-5m1ch7ls	2010	The existing burden of ill-health increases the sensitivity of Indigenous peoples to the adverse impacts of climate change, which combined with a proportionally higher dependence of many Indigenous Climate change Health Adaptation Vulnerability Aboriginal Inuit Mé tis First nations Canada Social determinants of health Inequality Indigenous A B S T R A C T Climate change has been identified as potentially the biggest health threat of the 21st century. However, there remains a significant deficit in information required to inform and guide adaptation among Aboriginal peoples-part of what we broadly term an Indigenous peoples ''vulnerability deficit.'' Major Canadian assessments of climate change, for example, identify research on Aboriginal health a priority for action , and while Furgal and Prowse (2008) focus on the health of mostly Inuit inhabitants in the north, other Aboriginal populations have been less studied (Healey and Meadows, 2007; Wilson and Young, 2008) .
cord-353827-o3vm1vdh	2020	These results underscore previous observations about the power of focusing events, but importantly, suggest that political polarization and avoidance of climate change talk may not prevent communities from taking adaptation-oriented policy action after an extreme weather event. Concurrently, a growing body of interdisciplinary literature seeks to better understand the link between the experience of an extreme weather event and individual beliefs, policy preferences, and local action in response to future disaster risk in the face of a changing climate. However, our analysis yielded one contradictory case, Suffolk County (NY), which was scored as being out of the set of cases that adopted adaptation-oriented policy, but which exhibits the conditions represented by the first recipe (Democratic AND Climate Change Attention). 12 Our analysis highlights the potential for adaptation-focused policy change in the wake of extreme weather events, even in communities that otherwise exhibit a strong avoidance of climate change discussion.
cord-354677-duxm9u8v	2020	
cord-354779-5jbehcb6	2019	
cord-355130-a2jc1g0i	2020	These universal agreements reflect a global consensus to address climate change and strive for sustainable and balanced social and economic development that promotes the well-being of socio-ecological systems. In this Perspective, we argue that in order to generate positive social and environmental changes globally, sustainability science must transform into a transdisciplinary enterprise. The evolution of what is now known as sustainability science has been important, but clearly it is not yet enough to play a pivotal role in social transformations needed for human preservation in the face of accelerating changes of the Anthropocene. Not only has failure to integrate important insights from the social sciences and environmental humanities limited the perceived ''''solution space'''' for responding to global challenges, but sustainability science has also failed to engage with the ''''how'''' of transformative change.
cord-355327-d3gcfepx	2009	Several classes of structural changes were observed, proteins that exhibit: disulfide oxidation following expulsion of metals such as zinc; major reorganisation of the polypeptide backbone in association with disulfide redox-activity; order/disorder transitions; and changes in quaternary structure. These groups were: proteins that oxidize disulfides following expulsion of metals such as Zn; proteins that exhibited major reorganization or ''''morphing'''' of portions of the polypeptide backbone in association with disulfide redox-activity; proteins that exhibited order/disorder transitions; and proteins that exhibited changes in quaternary structure. Twenty-nine Redox Pair protein clusters with intermolecular disulfide bonds exhibit changes in quaternary structure upon oxidation/reduction. We were previously aware of two instances where subdomain morphing of proteins has been associated with reversible disulfide reduction: a redox-controlled structural reorganization of the ion channel CLIC1 proposed to regulate its insertion into membranes, 18 and sequential oxidation of the transcription factor OxyR in response to oxidative stress which modulates its quaternary structure and DNA-binding properties.