id sid tid token lemma pos cord-028721-x6f26ahr 1 1 key key JJ cord-028721-x6f26ahr 2 1 : : : cord-028721-x6f26ahr 2 2 cord-028721-x6f26ahr cord-028721-x6f26ahr NNS cord-028721-x6f26ahr 2 3 authors author NNS cord-028721-x6f26ahr 2 4 : : : cord-028721-x6f26ahr 2 5 Nistal Nistal NNP cord-028721-x6f26ahr 2 6 , , , cord-028721-x6f26ahr 2 7 Manuel Manuel NNP cord-028721-x6f26ahr 2 8 ; ; : cord-028721-x6f26ahr 2 9 Paniagua Paniagua NNP cord-028721-x6f26ahr 2 10 , , , cord-028721-x6f26ahr 2 11 Ricardo Ricardo NNP cord-028721-x6f26ahr 2 12 title title NN cord-028721-x6f26ahr 2 13 : : : cord-028721-x6f26ahr 2 14 Non non JJ cord-028721-x6f26ahr 2 15 - - JJ cord-028721-x6f26ahr 2 16 neoplastic neoplastic JJ cord-028721-x6f26ahr 2 17 diseases disease NNS cord-028721-x6f26ahr 2 18 of of IN cord-028721-x6f26ahr 2 19 the the DT cord-028721-x6f26ahr 2 20 testis testis NN cord-028721-x6f26ahr 2 21 date date NN cord-028721-x6f26ahr 2 22 : : : cord-028721-x6f26ahr 2 23 2020 2020 CD cord-028721-x6f26ahr 2 24 - - HYPH cord-028721-x6f26ahr 2 25 06 06 CD cord-028721-x6f26ahr 2 26 - - SYM cord-028721-x6f26ahr 2 27 22 22 CD cord-028721-x6f26ahr 2 28 journal journal NN cord-028721-x6f26ahr 2 29 : : : cord-028721-x6f26ahr 3 1 Urologic urologic JJ cord-028721-x6f26ahr 3 2 Surgical Surgical NNP cord-028721-x6f26ahr 3 3 Pathology pathology NN cord-028721-x6f26ahr 3 4 DOI doi NN cord-028721-x6f26ahr 3 5 : : : cord-028721-x6f26ahr 4 1 10.1016 10.1016 CD cord-028721-x6f26ahr 4 2 / / SYM cord-028721-x6f26ahr 4 3 b978 b978 NNP cord-028721-x6f26ahr 4 4 - - HYPH cord-028721-x6f26ahr 4 5 0 0 CD cord-028721-x6f26ahr 4 6 - - HYPH cord-028721-x6f26ahr 4 7 323 323 CD cord-028721-x6f26ahr 4 8 - - HYPH cord-028721-x6f26ahr 4 9 01970 01970 CD cord-028721-x6f26ahr 4 10 - - HYPH cord-028721-x6f26ahr 4 11 5.50014 5.50014 CD cord-028721-x6f26ahr 4 12 - - SYM cord-028721-x6f26ahr 4 13 2 2 CD cord-028721-x6f26ahr 5 1 sha sha NNP cord-028721-x6f26ahr 5 2 : : : cord-028721-x6f26ahr 6 1 dcedc8ca7b10557df26adac7c517e7b123864747 dcedc8ca7b10557df26adac7c517e7b123864747 NFP cord-028721-x6f26ahr 6 2 doc_id doc_id CD cord-028721-x6f26ahr 6 3 : : : cord-028721-x6f26ahr 7 1 28721 28721 CD cord-028721-x6f26ahr 7 2 cord_uid cord_uid NNS cord-028721-x6f26ahr 7 3 : : : cord-028721-x6f26ahr 8 1 x6f26ahr x6f26ahr NNP cord-028721-x6f26ahr 8 2 nan nan NNP cord-028721-x6f26ahr 8 3 Testicular Testicular NNP cord-028721-x6f26ahr 8 4 biopsy biopsy NN cord-028721-x6f26ahr 8 5 665 665 CD cord-028721-x6f26ahr 8 6 Infertility Infertility NNP cord-028721-x6f26ahr 8 7 and and CC cord-028721-x6f26ahr 8 8 chromosomal chromosomal JJ cord-028721-x6f26ahr 8 9 anomalies anomaly NNS cord-028721-x6f26ahr 9 1 686 686 CD cord-028721-x6f26ahr 9 2 Other other JJ cord-028721-x6f26ahr 9 3 syndromes syndrome NNS cord-028721-x6f26ahr 9 4 associated associate VBN cord-028721-x6f26ahr 9 5 with with IN cord-028721-x6f26ahr 9 6 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 9 7 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 9 8 692 692 CD cord-028721-x6f26ahr 9 9 Secondary secondary JJ cord-028721-x6f26ahr 9 10 idiopathic idiopathic JJ cord-028721-x6f26ahr 9 11 hypogonadism hypogonadism NN cord-028721-x6f26ahr 9 12 694 694 CD cord-028721-x6f26ahr 9 13 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 9 14 secondary secondary JJ cord-028721-x6f26ahr 9 15 to to IN cord-028721-x6f26ahr 9 16 endocrine endocrine JJ cord-028721-x6f26ahr 9 17 gland gland NN cord-028721-x6f26ahr 9 18 dysfunction dysfunction NN cord-028721-x6f26ahr 9 19 697 697 CD cord-028721-x6f26ahr 9 20 Infertility Infertility NNP cord-028721-x6f26ahr 9 21 secondary secondary JJ cord-028721-x6f26ahr 9 22 to to IN cord-028721-x6f26ahr 9 23 physical physical JJ cord-028721-x6f26ahr 9 24 and and CC cord-028721-x6f26ahr 9 25 chemical chemical JJ cord-028721-x6f26ahr 9 26 agents agent NNS cord-028721-x6f26ahr 9 27 705 705 CD cord-028721-x6f26ahr 9 28 Infertility Infertility NNP cord-028721-x6f26ahr 9 29 in in IN cord-028721-x6f26ahr 9 30 patients patient NNS cord-028721-x6f26ahr 9 31 with with IN cord-028721-x6f26ahr 9 32 spinal spinal JJ cord-028721-x6f26ahr 9 33 cord cord NN cord-028721-x6f26ahr 9 34 injury injury NN cord-028721-x6f26ahr 9 35 708 708 CD cord-028721-x6f26ahr 9 36 Orchitis Orchitis NNP cord-028721-x6f26ahr 9 37 708 708 CD cord-028721-x6f26ahr 9 38 Histiocytosis Histiocytosis NNP cord-028721-x6f26ahr 9 39 with with IN cord-028721-x6f26ahr 9 40 testicular testicular JJ cord-028721-x6f26ahr 9 41 involvement involvement NN cord-028721-x6f26ahr 9 42 712 712 CD cord-028721-x6f26ahr 9 43 Non non JJ cord-028721-x6f26ahr 9 44 - - JJ cord-028721-x6f26ahr 9 45 neoplastic neoplastic JJ cord-028721-x6f26ahr 9 46 diseases disease NNS cord-028721-x6f26ahr 9 47 of of IN cord-028721-x6f26ahr 9 48 the the DT cord-028721-x6f26ahr 9 49 testis testis NN cord-028721-x6f26ahr 9 50 Manuel Manuel NNP cord-028721-x6f26ahr 9 51 Nistal Nistal NNP cord-028721-x6f26ahr 9 52 , , , cord-028721-x6f26ahr 9 53 Ricardo Ricardo NNP cord-028721-x6f26ahr 9 54 Paniagua Paniagua NNP cord-028721-x6f26ahr 9 55 CHAPTER chapter NN cord-028721-x6f26ahr 9 56 12 12 CD cord-028721-x6f26ahr 9 57 Embryology embryology NN cord-028721-x6f26ahr 9 58 and and CC cord-028721-x6f26ahr 9 59 anatomy anatomy NN cord-028721-x6f26ahr 9 60 of of IN cord-028721-x6f26ahr 9 61 the the DT cord-028721-x6f26ahr 9 62 testis testis NN cord-028721-x6f26ahr 9 63 Embryology Embryology NNP cord-028721-x6f26ahr 9 64 Sexual sexual JJ cord-028721-x6f26ahr 9 65 differentiation differentiation NN cord-028721-x6f26ahr 9 66 is be VBZ cord-028721-x6f26ahr 9 67 the the DT cord-028721-x6f26ahr 9 68 result result NN cord-028721-x6f26ahr 9 69 of of IN cord-028721-x6f26ahr 9 70 complex complex JJ cord-028721-x6f26ahr 9 71 genetic genetic JJ cord-028721-x6f26ahr 9 72 and and CC cord-028721-x6f26ahr 9 73 endocrine endocrine JJ cord-028721-x6f26ahr 9 74 mechanisms mechanism NNS cord-028721-x6f26ahr 9 75 that that WDT cord-028721-x6f26ahr 9 76 are be VBP cord-028721-x6f26ahr 9 77 closely closely RB cord-028721-x6f26ahr 9 78 associated associate VBN cord-028721-x6f26ahr 9 79 with with IN cord-028721-x6f26ahr 9 80 the the DT cord-028721-x6f26ahr 9 81 development development NN cord-028721-x6f26ahr 9 82 of of IN cord-028721-x6f26ahr 9 83 both both CC cord-028721-x6f26ahr 9 84 the the DT cord-028721-x6f26ahr 9 85 genitourinary genitourinary JJ cord-028721-x6f26ahr 9 86 system system NN cord-028721-x6f26ahr 9 87 and and CC cord-028721-x6f26ahr 9 88 the the DT cord-028721-x6f26ahr 9 89 adrenal adrenal JJ cord-028721-x6f26ahr 9 90 glands gland NNS cord-028721-x6f26ahr 9 91 . . . cord-028721-x6f26ahr 10 1 Formation formation NN cord-028721-x6f26ahr 10 2 of of IN cord-028721-x6f26ahr 10 3 the the DT cord-028721-x6f26ahr 10 4 bipotential bipotential NNP cord-028721-x6f26ahr 10 5 gonad gonad NNP cord-028721-x6f26ahr 10 6 and and CC cord-028721-x6f26ahr 10 7 , , , cord-028721-x6f26ahr 10 8 subsequently subsequently RB cord-028721-x6f26ahr 10 9 , , , cord-028721-x6f26ahr 10 10 of of IN cord-028721-x6f26ahr 10 11 the the DT cord-028721-x6f26ahr 10 12 ovaries ovary NNS cord-028721-x6f26ahr 10 13 and and CC cord-028721-x6f26ahr 10 14 testes testis NNS cord-028721-x6f26ahr 10 15 , , , cord-028721-x6f26ahr 10 16 depends depend VBZ cord-028721-x6f26ahr 10 17 on on IN cord-028721-x6f26ahr 10 18 gene gene NN cord-028721-x6f26ahr 10 19 expression expression NN cord-028721-x6f26ahr 10 20 in in IN cord-028721-x6f26ahr 10 21 both both CC cord-028721-x6f26ahr 10 22 sex sex NN cord-028721-x6f26ahr 10 23 and and CC cord-028721-x6f26ahr 10 24 autosomal autosomal JJ cord-028721-x6f26ahr 10 25 chromosomes chromosome NNS cord-028721-x6f26ahr 10 26 . . . cord-028721-x6f26ahr 11 1 Testes testis NNS cord-028721-x6f26ahr 11 2 secrete secrete VBP cord-028721-x6f26ahr 11 3 steroid steroid NN cord-028721-x6f26ahr 11 4 and and CC cord-028721-x6f26ahr 11 5 peptidic peptidic JJ cord-028721-x6f26ahr 11 6 hormones hormone NNS cord-028721-x6f26ahr 11 7 that that WDT cord-028721-x6f26ahr 11 8 are be VBP cord-028721-x6f26ahr 11 9 necessary necessary JJ cord-028721-x6f26ahr 11 10 for for IN cord-028721-x6f26ahr 11 11 the the DT cord-028721-x6f26ahr 11 12 development development NN cord-028721-x6f26ahr 11 13 of of IN cord-028721-x6f26ahr 11 14 inner inner JJ cord-028721-x6f26ahr 11 15 and and CC cord-028721-x6f26ahr 11 16 outer outer JJ cord-028721-x6f26ahr 11 17 male male JJ cord-028721-x6f26ahr 11 18 genitalia genitalia NNS cord-028721-x6f26ahr 11 19 . . . cord-028721-x6f26ahr 12 1 These these DT cord-028721-x6f26ahr 12 2 hormonal hormonal JJ cord-028721-x6f26ahr 12 3 actions action NNS cord-028721-x6f26ahr 12 4 are be VBP cord-028721-x6f26ahr 12 5 mediated mediate VBN cord-028721-x6f26ahr 12 6 by by IN cord-028721-x6f26ahr 12 7 specifi specifi NNP cord-028721-x6f26ahr 12 8 c c NNP cord-028721-x6f26ahr 12 9 receptors receptor NNS cord-028721-x6f26ahr 12 10 that that WDT cord-028721-x6f26ahr 12 11 are be VBP cord-028721-x6f26ahr 12 12 transcriptional transcriptional JJ cord-028721-x6f26ahr 12 13 regulators regulator NNS cord-028721-x6f26ahr 12 14 . . . cord-028721-x6f26ahr 13 1 Alteration alteration NN cord-028721-x6f26ahr 13 2 of of IN cord-028721-x6f26ahr 13 3 these these DT cord-028721-x6f26ahr 13 4 genetic genetic JJ cord-028721-x6f26ahr 13 5 events event NNS cord-028721-x6f26ahr 13 6 leads lead VBZ cord-028721-x6f26ahr 13 7 to to IN cord-028721-x6f26ahr 13 8 sexual sexual JJ cord-028721-x6f26ahr 13 9 dimorphism dimorphism NN cord-028721-x6f26ahr 13 10 involving involve VBG cord-028721-x6f26ahr 13 11 the the DT cord-028721-x6f26ahr 13 12 inner inner JJ cord-028721-x6f26ahr 13 13 and and CC cord-028721-x6f26ahr 13 14 outer outer JJ cord-028721-x6f26ahr 13 15 genitalia genitalia NNS cord-028721-x6f26ahr 13 16 , , , cord-028721-x6f26ahr 13 17 and and CC cord-028721-x6f26ahr 13 18 can can MD cord-028721-x6f26ahr 13 19 also also RB cord-028721-x6f26ahr 13 20 hinder hinder VB cord-028721-x6f26ahr 13 21 the the DT cord-028721-x6f26ahr 13 22 development development NN cord-028721-x6f26ahr 13 23 of of IN cord-028721-x6f26ahr 13 24 other other JJ cord-028721-x6f26ahr 13 25 organs organ NNS cord-028721-x6f26ahr 13 26 . . . cord-028721-x6f26ahr 14 1 1 1 LS cord-028721-x6f26ahr 14 2 Chromosomal chromosomal JJ cord-028721-x6f26ahr 14 3 gender gender NN cord-028721-x6f26ahr 14 4 is be VBZ cord-028721-x6f26ahr 14 5 established establish VBN cord-028721-x6f26ahr 14 6 at at IN cord-028721-x6f26ahr 14 7 fecundation fecundation NN cord-028721-x6f26ahr 14 8 with with IN cord-028721-x6f26ahr 14 9 formation formation NN cord-028721-x6f26ahr 14 10 of of IN cord-028721-x6f26ahr 14 11 an an DT cord-028721-x6f26ahr 14 12 egg egg NN cord-028721-x6f26ahr 14 13 with with IN cord-028721-x6f26ahr 14 14 either either CC cord-028721-x6f26ahr 14 15 a a DT cord-028721-x6f26ahr 14 16 46XY 46xy CD cord-028721-x6f26ahr 14 17 ( ( -LRB- cord-028721-x6f26ahr 14 18 male male NN cord-028721-x6f26ahr 14 19 ) ) -RRB- cord-028721-x6f26ahr 14 20 or or CC cord-028721-x6f26ahr 14 21 a a DT cord-028721-x6f26ahr 14 22 46XX 46xx CD cord-028721-x6f26ahr 14 23 ( ( -LRB- cord-028721-x6f26ahr 14 24 female female NN cord-028721-x6f26ahr 14 25 ) ) -RRB- cord-028721-x6f26ahr 14 26 karyotype karyotype NN cord-028721-x6f26ahr 14 27 . . . cord-028721-x6f26ahr 15 1 Each each DT cord-028721-x6f26ahr 15 2 chromosomal chromosomal JJ cord-028721-x6f26ahr 15 3 constitution constitution NN cord-028721-x6f26ahr 15 4 initiates initiate VBZ cord-028721-x6f26ahr 15 5 a a DT cord-028721-x6f26ahr 15 6 cascade cascade NN cord-028721-x6f26ahr 15 7 of of IN cord-028721-x6f26ahr 15 8 genetic genetic JJ cord-028721-x6f26ahr 15 9 events event NNS cord-028721-x6f26ahr 15 10 leading lead VBG cord-028721-x6f26ahr 15 11 to to IN cord-028721-x6f26ahr 15 12 the the DT cord-028721-x6f26ahr 15 13 development development NN cord-028721-x6f26ahr 15 14 of of IN cord-028721-x6f26ahr 15 15 female female JJ cord-028721-x6f26ahr 15 16 ( ( -LRB- cord-028721-x6f26ahr 15 17 ovaries ovary NNS cord-028721-x6f26ahr 15 18 ) ) -RRB- cord-028721-x6f26ahr 15 19 or or CC cord-028721-x6f26ahr 15 20 male male JJ cord-028721-x6f26ahr 15 21 ( ( -LRB- cord-028721-x6f26ahr 15 22 testes testis NNS cord-028721-x6f26ahr 15 23 ) ) -RRB- cord-028721-x6f26ahr 15 24 gonads gonad NNS cord-028721-x6f26ahr 15 25 ( ( -LRB- cord-028721-x6f26ahr 15 26 gonadal gonadal JJ cord-028721-x6f26ahr 15 27 gender gender NN cord-028721-x6f26ahr 15 28 ) ) -RRB- cord-028721-x6f26ahr 15 29 . . . cord-028721-x6f26ahr 16 1 Hormonal hormonal JJ cord-028721-x6f26ahr 16 2 secretions secretion NNS cord-028721-x6f26ahr 16 3 from from IN cord-028721-x6f26ahr 16 4 the the DT cord-028721-x6f26ahr 16 5 ovaries ovary NNS cord-028721-x6f26ahr 16 6 or or CC cord-028721-x6f26ahr 16 7 testes testis NNS cord-028721-x6f26ahr 16 8 are be VBP cord-028721-x6f26ahr 16 9 essential essential JJ cord-028721-x6f26ahr 16 10 for for IN cord-028721-x6f26ahr 16 11 the the DT cord-028721-x6f26ahr 16 12 development development NN cord-028721-x6f26ahr 16 13 of of IN cord-028721-x6f26ahr 16 14 external external JJ cord-028721-x6f26ahr 16 15 genitalia genitalia NNS cord-028721-x6f26ahr 16 16 ( ( -LRB- cord-028721-x6f26ahr 16 17 phenotypic phenotypic JJ cord-028721-x6f26ahr 16 18 gender gender NN cord-028721-x6f26ahr 16 19 ) ) -RRB- cord-028721-x6f26ahr 16 20 . . . cord-028721-x6f26ahr 17 1 The the DT cord-028721-x6f26ahr 17 2 relationship relationship NN cord-028721-x6f26ahr 17 3 between between IN cord-028721-x6f26ahr 17 4 the the DT cord-028721-x6f26ahr 17 5 individual individual NN cord-028721-x6f26ahr 17 6 and and CC cord-028721-x6f26ahr 17 7 the the DT cord-028721-x6f26ahr 17 8 environment environment NN cord-028721-x6f26ahr 17 9 determines determine VBZ cord-028721-x6f26ahr 17 10 the the DT cord-028721-x6f26ahr 17 11 social social JJ cord-028721-x6f26ahr 17 12 gender gender NN cord-028721-x6f26ahr 17 13 . . . cord-028721-x6f26ahr 18 1 There there EX cord-028721-x6f26ahr 18 2 are be VBP cord-028721-x6f26ahr 18 3 multiple multiple JJ cord-028721-x6f26ahr 18 4 genes gene NNS cord-028721-x6f26ahr 18 5 involved involve VBN cord-028721-x6f26ahr 18 6 in in IN cord-028721-x6f26ahr 18 7 the the DT cord-028721-x6f26ahr 18 8 formation formation NN cord-028721-x6f26ahr 18 9 of of IN cord-028721-x6f26ahr 18 10 the the DT cord-028721-x6f26ahr 18 11 undifferentiated undifferentiated JJ cord-028721-x6f26ahr 18 12 gonad gonad NN cord-028721-x6f26ahr 18 13 . . . cord-028721-x6f26ahr 19 1 The the DT cord-028721-x6f26ahr 19 2 two two CD cord-028721-x6f26ahr 19 3 most most RBS cord-028721-x6f26ahr 19 4 important important JJ cord-028721-x6f26ahr 19 5 for for IN cord-028721-x6f26ahr 19 6 the the DT cord-028721-x6f26ahr 19 7 proper proper JJ cord-028721-x6f26ahr 19 8 formation formation NN cord-028721-x6f26ahr 19 9 of of IN cord-028721-x6f26ahr 19 10 the the DT cord-028721-x6f26ahr 19 11 bipotential bipotential NNP cord-028721-x6f26ahr 19 12 gonad gonad NNP cord-028721-x6f26ahr 19 13 are be VBP cord-028721-x6f26ahr 19 14 WT1 wt1 JJ cord-028721-x6f26ahr 19 15 ( ( -LRB- cord-028721-x6f26ahr 19 16 Wilms Wilms NNP cord-028721-x6f26ahr 19 17 ' ' POS cord-028721-x6f26ahr 19 18 tumor tumor NN cord-028721-x6f26ahr 19 19 gene gene NN cord-028721-x6f26ahr 19 20 ) ) -RRB- cord-028721-x6f26ahr 19 21 and and CC cord-028721-x6f26ahr 19 22 NR5A1 NR5A1 NNP cord-028721-x6f26ahr 19 23 ( ( -LRB- cord-028721-x6f26ahr 19 24 Fig Fig NNP cord-028721-x6f26ahr 19 25 . . . cord-028721-x6f26ahr 19 26 12 12 CD cord-028721-x6f26ahr 19 27 - - SYM cord-028721-x6f26ahr 19 28 1 1 CD cord-028721-x6f26ahr 19 29 ) ) -RRB- cord-028721-x6f26ahr 19 30 . . . cord-028721-x6f26ahr 20 1 WT1 wt1 WP cord-028721-x6f26ahr 20 2 contains contain VBZ cord-028721-x6f26ahr 20 3 10 10 CD cord-028721-x6f26ahr 20 4 exons exon NNS cord-028721-x6f26ahr 20 5 located locate VBN cord-028721-x6f26ahr 20 6 on on IN cord-028721-x6f26ahr 20 7 chromosome chromosome NN cord-028721-x6f26ahr 20 8 11p13 11p13 CD cord-028721-x6f26ahr 20 9 , , , cord-028721-x6f26ahr 20 10 with with IN cord-028721-x6f26ahr 20 11 two two CD cord-028721-x6f26ahr 20 12 alternative alternative JJ cord-028721-x6f26ahr 20 13 splicing splicing NN cord-028721-x6f26ahr 20 14 loci locus NNS cord-028721-x6f26ahr 20 15 in in IN cord-028721-x6f26ahr 20 16 introns intron NNS cord-028721-x6f26ahr 20 17 5 5 CD cord-028721-x6f26ahr 20 18 and and CC cord-028721-x6f26ahr 20 19 9 9 CD cord-028721-x6f26ahr 20 20 . . . cord-028721-x6f26ahr 21 1 Intron intron NN cord-028721-x6f26ahr 21 2 9 9 CD cord-028721-x6f26ahr 21 3 splicing splicing NN cord-028721-x6f26ahr 21 4 can can MD cord-028721-x6f26ahr 21 5 lead lead VB cord-028721-x6f26ahr 21 6 to to IN cord-028721-x6f26ahr 21 7 the the DT cord-028721-x6f26ahr 21 8 inclusion inclusion NN cord-028721-x6f26ahr 21 9 or or CC cord-028721-x6f26ahr 21 10 exclusion exclusion NN cord-028721-x6f26ahr 21 11 of of IN cord-028721-x6f26ahr 21 12 three three CD cord-028721-x6f26ahr 21 13 amino amino NN cord-028721-x6f26ahr 21 14 acids acid NNS cord-028721-x6f26ahr 21 15 ( ( -LRB- cord-028721-x6f26ahr 21 16 KTS kts NN cord-028721-x6f26ahr 21 17 : : : cord-028721-x6f26ahr 21 18 lysine lysine NN cord-028721-x6f26ahr 21 19 , , , cord-028721-x6f26ahr 21 20 threonine threonine NN cord-028721-x6f26ahr 21 21 and and CC cord-028721-x6f26ahr 21 22 serine serine NN cord-028721-x6f26ahr 21 23 ) ) -RRB- cord-028721-x6f26ahr 21 24 , , , cord-028721-x6f26ahr 21 25 giving give VBG cord-028721-x6f26ahr 21 26 rise rise NN cord-028721-x6f26ahr 21 27 to to IN cord-028721-x6f26ahr 21 28 KTS+ KTS+ NNP cord-028721-x6f26ahr 21 29 or or CC cord-028721-x6f26ahr 21 30 KTS− kts− VB cord-028721-x6f26ahr 21 31 isoforms isoform NNS cord-028721-x6f26ahr 21 32 . . . cord-028721-x6f26ahr 22 1 An an DT cord-028721-x6f26ahr 22 2 adequate adequate JJ cord-028721-x6f26ahr 22 3 KTS+/KTS− kts+/kts− NN cord-028721-x6f26ahr 22 4 balance balance NN cord-028721-x6f26ahr 22 5 is be VBZ cord-028721-x6f26ahr 22 6 crucial crucial JJ cord-028721-x6f26ahr 22 7 for for IN cord-028721-x6f26ahr 22 8 normal normal JJ cord-028721-x6f26ahr 22 9 expression expression NN cord-028721-x6f26ahr 22 10 of of IN cord-028721-x6f26ahr 22 11 the the DT cord-028721-x6f26ahr 22 12 gene gene NN cord-028721-x6f26ahr 22 13 . . . cord-028721-x6f26ahr 23 1 Translation translation NN cord-028721-x6f26ahr 23 2 of of IN cord-028721-x6f26ahr 23 3 this this DT cord-028721-x6f26ahr 23 4 gene gene NN cord-028721-x6f26ahr 23 5 may may MD cord-028721-x6f26ahr 23 6 generate generate VB cord-028721-x6f26ahr 23 7 up up IN cord-028721-x6f26ahr 23 8 to to TO cord-028721-x6f26ahr 23 9 24 24 CD cord-028721-x6f26ahr 23 10 isoforms isoform NNS cord-028721-x6f26ahr 23 11 with with IN cord-028721-x6f26ahr 23 12 several several JJ cord-028721-x6f26ahr 23 13 zinc zinc NN cord-028721-x6f26ahr 23 14 - - HYPH cord-028721-x6f26ahr 23 15 fi fi NN cord-028721-x6f26ahr 23 16 nger nger NN cord-028721-x6f26ahr 23 17 domains domain NNS cord-028721-x6f26ahr 23 18 . . . cord-028721-x6f26ahr 24 1 This this DT cord-028721-x6f26ahr 24 2 gene gene NN cord-028721-x6f26ahr 24 3 is be VBZ cord-028721-x6f26ahr 24 4 expressed express VBN cord-028721-x6f26ahr 24 5 mainly mainly RB cord-028721-x6f26ahr 24 6 in in IN cord-028721-x6f26ahr 24 7 the the DT cord-028721-x6f26ahr 24 8 kidneys kidney NNS cord-028721-x6f26ahr 24 9 and and CC cord-028721-x6f26ahr 24 10 gonads gonad NNS cord-028721-x6f26ahr 24 11 , , , cord-028721-x6f26ahr 24 12 and and CC cord-028721-x6f26ahr 24 13 mediates mediate VBZ cord-028721-x6f26ahr 24 14 the the DT cord-028721-x6f26ahr 24 15 transition transition NN cord-028721-x6f26ahr 24 16 from from IN cord-028721-x6f26ahr 24 17 stroma stroma NN cord-028721-x6f26ahr 24 18 to to IN cord-028721-x6f26ahr 24 19 epithelium epithelium NN cord-028721-x6f26ahr 24 20 and and CC cord-028721-x6f26ahr 24 21 morphogenetic morphogenetic JJ cord-028721-x6f26ahr 24 22 differentiation differentiation NN cord-028721-x6f26ahr 24 23 ( ( -LRB- cord-028721-x6f26ahr 24 24 inhibits inhibit VBZ cord-028721-x6f26ahr 24 25 those those DT cord-028721-x6f26ahr 24 26 genes gene NNS cord-028721-x6f26ahr 24 27 that that WDT cord-028721-x6f26ahr 24 28 encode encode VBP cord-028721-x6f26ahr 24 29 proliferative proliferative JJ cord-028721-x6f26ahr 24 30 factors factor NNS cord-028721-x6f26ahr 24 31 and and CC cord-028721-x6f26ahr 24 32 activates activate VBZ cord-028721-x6f26ahr 24 33 those those DT cord-028721-x6f26ahr 24 34 that that WDT cord-028721-x6f26ahr 24 35 enhance enhance VBP cord-028721-x6f26ahr 24 36 epithelial epithelial JJ cord-028721-x6f26ahr 24 37 differentiation differentiation NN cord-028721-x6f26ahr 24 38 ) ) -RRB- cord-028721-x6f26ahr 24 39 . . . cord-028721-x6f26ahr 25 1 WT1 wt1 JJ cord-028721-x6f26ahr 25 2 gene gene NN cord-028721-x6f26ahr 25 3 anomalies anomaly NNS cord-028721-x6f26ahr 25 4 lead lead VBP cord-028721-x6f26ahr 25 5 to to IN cord-028721-x6f26ahr 25 6 a a DT cord-028721-x6f26ahr 25 7 wide wide JJ cord-028721-x6f26ahr 25 8 variety variety NN cord-028721-x6f26ahr 25 9 of of IN cord-028721-x6f26ahr 25 10 phenotypes phenotype NNS cord-028721-x6f26ahr 25 11 ; ; : cord-028721-x6f26ahr 25 12 deletions deletion NNS cord-028721-x6f26ahr 25 13 are be VBP cord-028721-x6f26ahr 25 14 associated associate VBN cord-028721-x6f26ahr 25 15 with with IN cord-028721-x6f26ahr 25 16 minimal minimal JJ cord-028721-x6f26ahr 25 17 genitourinary genitourinary JJ cord-028721-x6f26ahr 25 18 alterations alteration NNS cord-028721-x6f26ahr 25 19 and and CC cord-028721-x6f26ahr 25 20 predisposition predisposition NN cord-028721-x6f26ahr 25 21 to to TO cord-028721-x6f26ahr 25 22 develop develop VB cord-028721-x6f26ahr 25 23 Wilms Wilms NNP cord-028721-x6f26ahr 25 24 ' ' POS cord-028721-x6f26ahr 25 25 tumor tumor NN cord-028721-x6f26ahr 25 26 . . . cord-028721-x6f26ahr 26 1 [ [ -LRB- cord-028721-x6f26ahr 26 2 2 2 LS cord-028721-x6f26ahr 26 3 ] ] -RRB- cord-028721-x6f26ahr 26 4 [ [ -LRB- cord-028721-x6f26ahr 26 5 3 3 CD cord-028721-x6f26ahr 26 6 ] ] -RRB- cord-028721-x6f26ahr 26 7 [ [ -LRB- cord-028721-x6f26ahr 26 8 4 4 CD cord-028721-x6f26ahr 26 9 ] ] -RRB- cord-028721-x6f26ahr 26 10 Missense Missense NNP cord-028721-x6f26ahr 26 11 heterozygous heterozygous JJ cord-028721-x6f26ahr 26 12 mutations mutation NNS cord-028721-x6f26ahr 26 13 give give VBP cord-028721-x6f26ahr 26 14 rise rise NN cord-028721-x6f26ahr 26 15 to to IN cord-028721-x6f26ahr 26 16 Denys Denys NNP cord-028721-x6f26ahr 26 17 - - HYPH cord-028721-x6f26ahr 26 18 Drash Drash NNP cord-028721-x6f26ahr 26 19 syndrome syndrome NN cord-028721-x6f26ahr 26 20 ( ( -LRB- cord-028721-x6f26ahr 26 21 complete complete JJ cord-028721-x6f26ahr 26 22 or or CC cord-028721-x6f26ahr 26 23 partial partial JJ cord-028721-x6f26ahr 26 24 46XY 46xy CD cord-028721-x6f26ahr 26 25 gonadal gonadal JJ cord-028721-x6f26ahr 26 26 dysgenesis dysgenesis NN cord-028721-x6f26ahr 26 27 , , , cord-028721-x6f26ahr 26 28 renal renal JJ cord-028721-x6f26ahr 26 29 disease disease NN cord-028721-x6f26ahr 26 30 of of IN cord-028721-x6f26ahr 26 31 early early JJ cord-028721-x6f26ahr 26 32 onset onset NN cord-028721-x6f26ahr 26 33 with with IN cord-028721-x6f26ahr 26 34 diffuse diffuse JJ cord-028721-x6f26ahr 26 35 mesangial mesangial JJ cord-028721-x6f26ahr 26 36 sclerosis sclerosis NN cord-028721-x6f26ahr 26 37 , , , cord-028721-x6f26ahr 26 38 and and CC cord-028721-x6f26ahr 26 39 Wilms Wilms NNP cord-028721-x6f26ahr 26 40 ' ' POS cord-028721-x6f26ahr 26 41 tumor tumor NN cord-028721-x6f26ahr 26 42 ( ( -LRB- cord-028721-x6f26ahr 26 43 OMIM OMIM NNP cord-028721-x6f26ahr 26 44 19408 19408 CD cord-028721-x6f26ahr 26 45 ) ) -RRB- cord-028721-x6f26ahr 26 46 ) ) -RRB- cord-028721-x6f26ahr 26 47 . . . cord-028721-x6f26ahr 27 1 5 5 CD cord-028721-x6f26ahr 27 2 Loss loss NN cord-028721-x6f26ahr 27 3 of of IN cord-028721-x6f26ahr 27 4 the the DT cord-028721-x6f26ahr 27 5 KTS+ KTS+ NNP cord-028721-x6f26ahr 27 6 isoform isoform NN cord-028721-x6f26ahr 27 7 accounts account VBZ cord-028721-x6f26ahr 27 8 for for IN cord-028721-x6f26ahr 27 9 Frasier Frasier NNP cord-028721-x6f26ahr 27 10 's 's POS cord-028721-x6f26ahr 27 11 syndrome syndrome NN cord-028721-x6f26ahr 27 12 ( ( -LRB- cord-028721-x6f26ahr 27 13 46XY 46xy CD cord-028721-x6f26ahr 27 14 gonadal gonadal JJ cord-028721-x6f26ahr 27 15 dysgenesis dysgenesis NN cord-028721-x6f26ahr 27 16 , , , cord-028721-x6f26ahr 27 17 renal renal JJ cord-028721-x6f26ahr 27 18 disease disease NN cord-028721-x6f26ahr 27 19 of of IN cord-028721-x6f26ahr 27 20 late late JJ cord-028721-x6f26ahr 27 21 onset onset NN cord-028721-x6f26ahr 27 22 and and CC cord-028721-x6f26ahr 27 23 absence absence NN cord-028721-x6f26ahr 27 24 of of IN cord-028721-x6f26ahr 27 25 Wilms Wilms NNP cord-028721-x6f26ahr 27 26 ' ' POS cord-028721-x6f26ahr 27 27 tumor tumor NN cord-028721-x6f26ahr 27 28 ( ( -LRB- cord-028721-x6f26ahr 27 29 OMIM OMIM NNP cord-028721-x6f26ahr 27 30 136680 136680 CD cord-028721-x6f26ahr 27 31 ) ) -RRB- cord-028721-x6f26ahr 27 32 ) ) -RRB- cord-028721-x6f26ahr 27 33 . . . cord-028721-x6f26ahr 28 1 6 6 CD cord-028721-x6f26ahr 29 1 NR5A1 NR5A1 NNP cord-028721-x6f26ahr 29 2 gene gene NN cord-028721-x6f26ahr 29 3 product product NN cord-028721-x6f26ahr 29 4 is be VBZ cord-028721-x6f26ahr 29 5 termed term VBN cord-028721-x6f26ahr 29 6 SF-1 SF-1 NNP cord-028721-x6f26ahr 30 1 ( ( -LRB- cord-028721-x6f26ahr 30 2 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 30 3 factor factor NN cord-028721-x6f26ahr 30 4 1 1 CD cord-028721-x6f26ahr 30 5 ) ) -RRB- cord-028721-x6f26ahr 30 6 . . . cord-028721-x6f26ahr 31 1 The the DT cord-028721-x6f26ahr 31 2 gene gene NN cord-028721-x6f26ahr 31 3 has have VBZ cord-028721-x6f26ahr 31 4 seven seven CD cord-028721-x6f26ahr 31 5 exons exon NNS cord-028721-x6f26ahr 31 6 in in IN cord-028721-x6f26ahr 31 7 chromosome chromosome NN cord-028721-x6f26ahr 31 8 9q33.3 9q33.3 CD cord-028721-x6f26ahr 31 9 , , , cord-028721-x6f26ahr 31 10 and and CC cord-028721-x6f26ahr 31 11 is be VBZ cord-028721-x6f26ahr 31 12 expressed express VBN cord-028721-x6f26ahr 31 13 in in IN cord-028721-x6f26ahr 31 14 the the DT cord-028721-x6f26ahr 31 15 urogenital urogenital JJ cord-028721-x6f26ahr 31 16 ridge ridge NN cord-028721-x6f26ahr 31 17 that that WDT cord-028721-x6f26ahr 31 18 forms form VBZ cord-028721-x6f26ahr 31 19 the the DT cord-028721-x6f26ahr 31 20 gonads gonad NNS cord-028721-x6f26ahr 31 21 and and CC cord-028721-x6f26ahr 31 22 adrenal adrenal JJ cord-028721-x6f26ahr 31 23 glands gland NNS cord-028721-x6f26ahr 31 24 . . . cord-028721-x6f26ahr 32 1 SF-1 SF-1 NNP cord-028721-x6f26ahr 33 1 promotes promote VBZ cord-028721-x6f26ahr 33 2 the the DT cord-028721-x6f26ahr 33 3 expression expression NN cord-028721-x6f26ahr 33 4 of of IN cord-028721-x6f26ahr 33 5 the the DT cord-028721-x6f26ahr 33 6 anti anti JJ cord-028721-x6f26ahr 33 7 - - JJ cord-028721-x6f26ahr 33 8 müllerian müllerian JJ cord-028721-x6f26ahr 33 9 hormone hormone NN cord-028721-x6f26ahr 33 10 ( ( -LRB- cord-028721-x6f26ahr 33 11 AMH AMH NNP cord-028721-x6f26ahr 33 12 ) ) -RRB- cord-028721-x6f26ahr 33 13 and and CC cord-028721-x6f26ahr 33 14 joins join VBZ cord-028721-x6f26ahr 33 15 elements element NNS cord-028721-x6f26ahr 33 16 that that WDT cord-028721-x6f26ahr 33 17 regulate regulate VBP cord-028721-x6f26ahr 33 18 upstream upstream IN cord-028721-x6f26ahr 33 19 the the DT cord-028721-x6f26ahr 33 20 AMH amh NN cord-028721-x6f26ahr 33 21 gene gene NN cord-028721-x6f26ahr 33 22 . . . cord-028721-x6f26ahr 34 1 SF-1 SF-1 NNP cord-028721-x6f26ahr 35 1 is be VBZ cord-028721-x6f26ahr 35 2 fi fi NNP cord-028721-x6f26ahr 35 3 rst rst NNP cord-028721-x6f26ahr 35 4 detected detect VBN cord-028721-x6f26ahr 35 5 in in IN cord-028721-x6f26ahr 35 6 the the DT cord-028721-x6f26ahr 35 7 developing develop VBG cord-028721-x6f26ahr 35 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 35 9 cells cell NNS cord-028721-x6f26ahr 35 10 of of IN cord-028721-x6f26ahr 35 11 sex sex NN cord-028721-x6f26ahr 35 12 cords cord NNS cord-028721-x6f26ahr 35 13 , , , cord-028721-x6f26ahr 35 14 but but CC cord-028721-x6f26ahr 35 15 later later RB cord-028721-x6f26ahr 35 16 is be VBZ cord-028721-x6f26ahr 35 17 mainly mainly RB cord-028721-x6f26ahr 35 18 localized localize VBN cord-028721-x6f26ahr 35 19 in in IN cord-028721-x6f26ahr 35 20 Leydig Leydig NNP cord-028721-x6f26ahr 35 21 cells cell NNS cord-028721-x6f26ahr 35 22 . . . cord-028721-x6f26ahr 36 1 7 7 CD cord-028721-x6f26ahr 37 1 A a DT cord-028721-x6f26ahr 37 2 heterozygous heterozygous JJ cord-028721-x6f26ahr 37 3 deletion deletion NN cord-028721-x6f26ahr 37 4 causes cause VBZ cord-028721-x6f26ahr 37 5 a a DT cord-028721-x6f26ahr 37 6 female female JJ cord-028721-x6f26ahr 37 7 phenotype phenotype NN cord-028721-x6f26ahr 37 8 in in IN cord-028721-x6f26ahr 37 9 patients patient NNS cord-028721-x6f26ahr 37 10 with with IN cord-028721-x6f26ahr 37 11 46XY 46xy CD cord-028721-x6f26ahr 37 12 , , , cord-028721-x6f26ahr 37 13 adrenal adrenal JJ cord-028721-x6f26ahr 37 14 failure failure NN cord-028721-x6f26ahr 37 15 during during IN cord-028721-x6f26ahr 37 16 the the DT cord-028721-x6f26ahr 37 17 fi fi NN cord-028721-x6f26ahr 37 18 rst rst NNP cord-028721-x6f26ahr 37 19 weeks week NNS cord-028721-x6f26ahr 37 20 of of IN cord-028721-x6f26ahr 37 21 extrauterine extrauterine NNP cord-028721-x6f26ahr 37 22 life life NN cord-028721-x6f26ahr 37 23 , , , cord-028721-x6f26ahr 37 24 persistence persistence NN cord-028721-x6f26ahr 37 25 of of IN cord-028721-x6f26ahr 37 26 normal normal JJ cord-028721-x6f26ahr 37 27 müllerian müllerian JJ cord-028721-x6f26ahr 37 28 structures structure NNS cord-028721-x6f26ahr 37 29 , , , cord-028721-x6f26ahr 37 30 and and CC cord-028721-x6f26ahr 37 31 gonads gonad NNS cord-028721-x6f26ahr 37 32 consisting consist VBG cord-028721-x6f26ahr 37 33 of of IN cord-028721-x6f26ahr 37 34 poorly poorly RB cord-028721-x6f26ahr 37 35 differentiated differentiate VBN cord-028721-x6f26ahr 37 36 tubules tubule NNS cord-028721-x6f26ahr 37 37 embedded embed VBN cord-028721-x6f26ahr 37 38 in in IN cord-028721-x6f26ahr 37 39 abundant abundant JJ cord-028721-x6f26ahr 37 40 connective connective JJ cord-028721-x6f26ahr 37 41 tissue tissue NN cord-028721-x6f26ahr 37 42 . . . cord-028721-x6f26ahr 38 1 These these DT cord-028721-x6f26ahr 38 2 patients patient NNS cord-028721-x6f26ahr 38 3 do do VBP cord-028721-x6f26ahr 38 4 not not RB cord-028721-x6f26ahr 38 5 respond respond VB cord-028721-x6f26ahr 38 6 to to IN cord-028721-x6f26ahr 38 7 hCG hcg JJ cord-028721-x6f26ahr 38 8 stimulation stimulation NN cord-028721-x6f26ahr 38 9 . . . cord-028721-x6f26ahr 39 1 8 8 CD cord-028721-x6f26ahr 40 1 In in IN cord-028721-x6f26ahr 40 2 46XX 46xx CD cord-028721-x6f26ahr 40 3 patients patient NNS cord-028721-x6f26ahr 40 4 , , , cord-028721-x6f26ahr 40 5 ovarian ovarian JJ cord-028721-x6f26ahr 40 6 development development NN cord-028721-x6f26ahr 40 7 is be VBZ cord-028721-x6f26ahr 40 8 not not RB cord-028721-x6f26ahr 40 9 modifi modifi JJ cord-028721-x6f26ahr 40 10 ed ed NN cord-028721-x6f26ahr 40 11 by by IN cord-028721-x6f26ahr 40 12 SF-1 SF-1 NNP cord-028721-x6f26ahr 40 13 mutations mutation NNS cord-028721-x6f26ahr 40 14 , , , cord-028721-x6f26ahr 40 15 and and CC cord-028721-x6f26ahr 40 16 they -PRON- PRP cord-028721-x6f26ahr 40 17 present present VBP cord-028721-x6f26ahr 40 18 with with IN cord-028721-x6f26ahr 40 19 adrenal adrenal JJ cord-028721-x6f26ahr 40 20 failure failure NN cord-028721-x6f26ahr 40 21 only only RB cord-028721-x6f26ahr 40 22 . . . cord-028721-x6f26ahr 41 1 9 9 CD cord-028721-x6f26ahr 41 2 LIM-1 LIM-1 NNP cord-028721-x6f26ahr 41 3 is be VBZ cord-028721-x6f26ahr 41 4 another another DT cord-028721-x6f26ahr 41 5 gene gene NN cord-028721-x6f26ahr 41 6 involved involve VBN cord-028721-x6f26ahr 41 7 in in IN cord-028721-x6f26ahr 41 8 the the DT cord-028721-x6f26ahr 41 9 formation formation NN cord-028721-x6f26ahr 41 10 of of IN cord-028721-x6f26ahr 41 11 the the DT cord-028721-x6f26ahr 41 12 bipotential bipotential NNP cord-028721-x6f26ahr 41 13 gonad gonad NN cord-028721-x6f26ahr 41 14 and and CC cord-028721-x6f26ahr 41 15 kidneys kidney NNS cord-028721-x6f26ahr 41 16 . . . cord-028721-x6f26ahr 42 1 It -PRON- PRP cord-028721-x6f26ahr 42 2 was be VBD cord-028721-x6f26ahr 42 3 recently recently RB cord-028721-x6f26ahr 42 4 identifi identifi VBN cord-028721-x6f26ahr 42 5 ed ed NN cord-028721-x6f26ahr 42 6 in in IN cord-028721-x6f26ahr 42 7 mice mouse NNS cord-028721-x6f26ahr 42 8 that that WDT cord-028721-x6f26ahr 42 9 bore bear VBD cord-028721-x6f26ahr 42 10 homozygous homozygous JJ cord-028721-x6f26ahr 42 11 deletions deletion NNS cord-028721-x6f26ahr 42 12 and and CC cord-028721-x6f26ahr 42 13 presented present VBN cord-028721-x6f26ahr 42 14 alterations alteration NNS cord-028721-x6f26ahr 42 15 in in IN cord-028721-x6f26ahr 42 16 both both DT cord-028721-x6f26ahr 42 17 organs organ NNS cord-028721-x6f26ahr 42 18 . . . cord-028721-x6f26ahr 43 1 10 10 CD cord-028721-x6f26ahr 43 2 FGF-9 FGF-9 NNP cord-028721-x6f26ahr 43 3 ( ( -LRB- cord-028721-x6f26ahr 43 4 fi fi IN cord-028721-x6f26ahr 43 5 broblastic broblastic JJ cord-028721-x6f26ahr 43 6 growth growth NN cord-028721-x6f26ahr 43 7 factor factor NN cord-028721-x6f26ahr 43 8 9 9 CD cord-028721-x6f26ahr 43 9 ) ) -RRB- cord-028721-x6f26ahr 43 10 has have VBZ cord-028721-x6f26ahr 43 11 also also RB cord-028721-x6f26ahr 43 12 been be VBN cord-028721-x6f26ahr 43 13 related relate VBN cord-028721-x6f26ahr 43 14 to to IN cord-028721-x6f26ahr 43 15 gonadal gonadal JJ cord-028721-x6f26ahr 43 16 development development NN cord-028721-x6f26ahr 43 17 . . . cord-028721-x6f26ahr 44 1 Both both DT cord-028721-x6f26ahr 44 2 gonosomal gonosomal NNS cord-028721-x6f26ahr 44 3 and and CC cord-028721-x6f26ahr 44 4 autosomal autosomal JJ cord-028721-x6f26ahr 44 5 genes gene NNS cord-028721-x6f26ahr 44 6 mediate mediate VBP cord-028721-x6f26ahr 44 7 the the DT cord-028721-x6f26ahr 44 8 progression progression NN cord-028721-x6f26ahr 44 9 of of IN cord-028721-x6f26ahr 44 10 the the DT cord-028721-x6f26ahr 44 11 bipotential bipotential NNP cord-028721-x6f26ahr 44 12 gonad gonad NN cord-028721-x6f26ahr 44 13 toward toward IN cord-028721-x6f26ahr 44 14 testicular testicular JJ cord-028721-x6f26ahr 44 15 differentiation differentiation NN cord-028721-x6f26ahr 44 16 . . . cord-028721-x6f26ahr 45 1 The the DT cord-028721-x6f26ahr 45 2 signal signal NN cord-028721-x6f26ahr 45 3 is be VBZ cord-028721-x6f26ahr 45 4 triggered trigger VBN cord-028721-x6f26ahr 45 5 by by IN cord-028721-x6f26ahr 45 6 the the DT cord-028721-x6f26ahr 45 7 SRY SRY NNP cord-028721-x6f26ahr 45 8 gene gene NN cord-028721-x6f26ahr 45 9 on on IN cord-028721-x6f26ahr 45 10 the the DT cord-028721-x6f26ahr 45 11 distal distal JJ cord-028721-x6f26ahr 45 12 portion portion NN cord-028721-x6f26ahr 45 13 of of IN cord-028721-x6f26ahr 45 14 the the DT cord-028721-x6f26ahr 45 15 short short JJ cord-028721-x6f26ahr 45 16 arm arm NN cord-028721-x6f26ahr 45 17 of of IN cord-028721-x6f26ahr 45 18 the the DT cord-028721-x6f26ahr 45 19 Y Y NNP cord-028721-x6f26ahr 45 20 chromosome chromosome NN cord-028721-x6f26ahr 45 21 ( ( -LRB- cord-028721-x6f26ahr 45 22 sexdetermining sexdetermine VBG cord-028721-x6f26ahr 45 23 region region NN cord-028721-x6f26ahr 45 24 of of IN cord-028721-x6f26ahr 45 25 the the DT cord-028721-x6f26ahr 45 26 Y Y NNP cord-028721-x6f26ahr 45 27 chromosome chromosome NN cord-028721-x6f26ahr 45 28 ; ; : cord-028721-x6f26ahr 45 29 Yp11.3 yp11.3 ADD cord-028721-x6f26ahr 45 30 ) ) -RRB- cord-028721-x6f26ahr 45 31 , , , cord-028721-x6f26ahr 45 32 also also RB cord-028721-x6f26ahr 45 33 called call VBN cord-028721-x6f26ahr 45 34 TDF TDF NNP cord-028721-x6f26ahr 45 35 ( ( -LRB- cord-028721-x6f26ahr 45 36 testis testis NN cord-028721-x6f26ahr 45 37 determining determine VBG cord-028721-x6f26ahr 45 38 factor factor NN cord-028721-x6f26ahr 45 39 gene gene NN cord-028721-x6f26ahr 45 40 ) ) -RRB- cord-028721-x6f26ahr 45 41 . . . cord-028721-x6f26ahr 46 1 11 11 CD cord-028721-x6f26ahr 47 1 This this DT cord-028721-x6f26ahr 47 2 gene gene NN cord-028721-x6f26ahr 47 3 stimulates stimulate VBZ cord-028721-x6f26ahr 47 4 the the DT cord-028721-x6f26ahr 47 5 differentiation differentiation NN cord-028721-x6f26ahr 47 6 of of IN cord-028721-x6f26ahr 47 7 Sertoli sertoli JJ cord-028721-x6f26ahr 47 8 cell cell NN cord-028721-x6f26ahr 47 9 precursors precursor NNS cord-028721-x6f26ahr 47 10 and and CC cord-028721-x6f26ahr 47 11 germ germ NN cord-028721-x6f26ahr 47 12 cells cell NNS cord-028721-x6f26ahr 47 13 , , , cord-028721-x6f26ahr 47 14 is be VBZ cord-028721-x6f26ahr 47 15 responsible responsible JJ cord-028721-x6f26ahr 47 16 for for IN cord-028721-x6f26ahr 47 17 the the DT cord-028721-x6f26ahr 47 18 production production NN cord-028721-x6f26ahr 47 19 of of IN cord-028721-x6f26ahr 47 20 the the DT cord-028721-x6f26ahr 47 21 anti anti JJ cord-028721-x6f26ahr 47 22 - - JJ cord-028721-x6f26ahr 47 23 müllerian müllerian JJ cord-028721-x6f26ahr 47 24 hormone hormone NN cord-028721-x6f26ahr 47 25 , , , cord-028721-x6f26ahr 47 26 12 12 CD cord-028721-x6f26ahr 47 27 and and CC cord-028721-x6f26ahr 47 28 regulates regulate VBZ cord-028721-x6f26ahr 47 29 other other JJ cord-028721-x6f26ahr 47 30 genes gene NNS cord-028721-x6f26ahr 47 31 of of IN cord-028721-x6f26ahr 47 32 the the DT cord-028721-x6f26ahr 47 33 downstream downstream JJ cord-028721-x6f26ahr 47 34 cascade cascade NN cord-028721-x6f26ahr 47 35 . . . cord-028721-x6f26ahr 48 1 These these DT cord-028721-x6f26ahr 48 2 are be VBP cord-028721-x6f26ahr 48 3 either either RB cord-028721-x6f26ahr 48 4 activated activate VBN cord-028721-x6f26ahr 48 5 or or CC cord-028721-x6f26ahr 48 6 inhibited inhibit VBN cord-028721-x6f26ahr 48 7 by by IN cord-028721-x6f26ahr 48 8 other other JJ cord-028721-x6f26ahr 48 9 genes gene NNS cord-028721-x6f26ahr 48 10 in in IN cord-028721-x6f26ahr 48 11 such such PDT cord-028721-x6f26ahr 48 12 a a DT cord-028721-x6f26ahr 48 13 way way NN cord-028721-x6f26ahr 48 14 that that WDT cord-028721-x6f26ahr 48 15 dozens dozen NNS cord-028721-x6f26ahr 48 16 of of IN cord-028721-x6f26ahr 48 17 genes gene NNS cord-028721-x6f26ahr 48 18 are be VBP cord-028721-x6f26ahr 48 19 involved involve VBN cord-028721-x6f26ahr 48 20 in in IN cord-028721-x6f26ahr 48 21 testicular testicular JJ cord-028721-x6f26ahr 48 22 differentiation differentiation NN cord-028721-x6f26ahr 48 23 . . . cord-028721-x6f26ahr 49 1 13 13 CD cord-028721-x6f26ahr 50 1 The the DT cord-028721-x6f26ahr 50 2 SRY SRY NNP cord-028721-x6f26ahr 50 3 gene gene NN cord-028721-x6f26ahr 50 4 contains contain VBZ cord-028721-x6f26ahr 50 5 a a DT cord-028721-x6f26ahr 50 6 single single JJ cord-028721-x6f26ahr 50 7 exon exon NN cord-028721-x6f26ahr 50 8 that that WDT cord-028721-x6f26ahr 50 9 encodes encode VBZ cord-028721-x6f26ahr 50 10 a a DT cord-028721-x6f26ahr 50 11 204 204 CD cord-028721-x6f26ahr 50 12 amino amino NN cord-028721-x6f26ahr 50 13 acid acid NN cord-028721-x6f26ahr 50 14 protein protein NN cord-028721-x6f26ahr 50 15 whose whose WP$ cord-028721-x6f26ahr 50 16 central central JJ cord-028721-x6f26ahr 50 17 part part NN cord-028721-x6f26ahr 50 18 ( ( -LRB- cord-028721-x6f26ahr 50 19 79 79 CD cord-028721-x6f26ahr 50 20 amino amino JJ cord-028721-x6f26ahr 50 21 acids acid NNS cord-028721-x6f26ahr 50 22 ) ) -RRB- cord-028721-x6f26ahr 50 23 encodes encode VBZ cord-028721-x6f26ahr 50 24 a a DT cord-028721-x6f26ahr 50 25 DNA dna NN cord-028721-x6f26ahr 50 26 - - HYPH cord-028721-x6f26ahr 50 27 binding bind VBG cord-028721-x6f26ahr 50 28 domain domain NN cord-028721-x6f26ahr 50 29 termed term VBN cord-028721-x6f26ahr 50 30 HMG HMG NNP cord-028721-x6f26ahr 50 31 ( ( -LRB- cord-028721-x6f26ahr 50 32 high high JJ cord-028721-x6f26ahr 50 33 mobil- mobil- NNP cord-028721-x6f26ahr 50 34 ity ity NN cord-028721-x6f26ahr 50 35 group group NN cord-028721-x6f26ahr 50 36 ) ) -RRB- cord-028721-x6f26ahr 50 37 . . . cord-028721-x6f26ahr 51 1 Immunohistochemical Immunohistochemical NNP cord-028721-x6f26ahr 51 2 studies study NNS cord-028721-x6f26ahr 51 3 have have VBP cord-028721-x6f26ahr 51 4 demonstrated demonstrate VBN cord-028721-x6f26ahr 51 5 expression expression NN cord-028721-x6f26ahr 51 6 of of IN cord-028721-x6f26ahr 51 7 the the DT cord-028721-x6f26ahr 51 8 SRY SRY NNP cord-028721-x6f26ahr 51 9 gene gene NN cord-028721-x6f26ahr 51 10 in in IN cord-028721-x6f26ahr 51 11 the the DT cord-028721-x6f26ahr 51 12 nuclei nucleus NNS cord-028721-x6f26ahr 51 13 of of IN cord-028721-x6f26ahr 51 14 both both DT cord-028721-x6f26ahr 51 15 Sertoli sertoli JJ cord-028721-x6f26ahr 51 16 cells cell NNS cord-028721-x6f26ahr 51 17 and and CC cord-028721-x6f26ahr 51 18 germ germ NN cord-028721-x6f26ahr 51 19 cells cell NNS cord-028721-x6f26ahr 51 20 , , , cord-028721-x6f26ahr 51 21 14 14 CD cord-028721-x6f26ahr 51 22 suggesting suggest VBG cord-028721-x6f26ahr 51 23 that that IN cord-028721-x6f26ahr 51 24 this this DT cord-028721-x6f26ahr 51 25 gene gene NN cord-028721-x6f26ahr 51 26 acts act VBZ cord-028721-x6f26ahr 51 27 in in IN cord-028721-x6f26ahr 51 28 somatic somatic JJ cord-028721-x6f26ahr 51 29 cells cell NNS cord-028721-x6f26ahr 51 30 of of IN cord-028721-x6f26ahr 51 31 genital genital JJ cord-028721-x6f26ahr 51 32 ridge ridge NN cord-028721-x6f26ahr 51 33 and and CC cord-028721-x6f26ahr 51 34 germ germ NN cord-028721-x6f26ahr 51 35 cells cell NNS cord-028721-x6f26ahr 51 36 . . . cord-028721-x6f26ahr 52 1 SRY sry UH cord-028721-x6f26ahr 52 2 works work VBZ cord-028721-x6f26ahr 52 3 with with IN cord-028721-x6f26ahr 52 4 the the DT cord-028721-x6f26ahr 52 5 AMH amh NN cord-028721-x6f26ahr 52 6 promoter promoter NN cord-028721-x6f26ahr 52 7 gene gene NN cord-028721-x6f26ahr 52 8 and and CC cord-028721-x6f26ahr 52 9 also also RB cord-028721-x6f26ahr 52 10 regulates regulate VBZ cord-028721-x6f26ahr 52 11 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 52 12 hormone hormone NN cord-028721-x6f26ahr 52 13 expression expression NN cord-028721-x6f26ahr 52 14 . . . cord-028721-x6f26ahr 53 1 15 15 CD cord-028721-x6f26ahr 53 2 SRY SRY NNP cord-028721-x6f26ahr 53 3 mutations mutation NNS cord-028721-x6f26ahr 53 4 produce produce VBP cord-028721-x6f26ahr 53 5 pure pure JJ cord-028721-x6f26ahr 53 6 gonadal gonadal JJ cord-028721-x6f26ahr 53 7 dysgenesis dysgenesis FW cord-028721-x6f26ahr 53 8 ( ( -LRB- cord-028721-x6f26ahr 53 9 Swyer Swyer NNP cord-028721-x6f26ahr 53 10 's 's POS cord-028721-x6f26ahr 53 11 syndrome syndrome NN cord-028721-x6f26ahr 53 12 ) ) -RRB- cord-028721-x6f26ahr 53 13 or or CC cord-028721-x6f26ahr 53 14 true true JJ cord-028721-x6f26ahr 53 15 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 53 16 ; ; : cord-028721-x6f26ahr 53 17 the the DT cord-028721-x6f26ahr 53 18 karyotype karyotype NN cord-028721-x6f26ahr 53 19 of of IN cord-028721-x6f26ahr 53 20 patients patient NNS cord-028721-x6f26ahr 53 21 with with IN cord-028721-x6f26ahr 53 22 the the DT cord-028721-x6f26ahr 53 23 male male JJ cord-028721-x6f26ahr 53 24 phenotype phenotype NN cord-028721-x6f26ahr 53 25 lacking lack VBG cord-028721-x6f26ahr 53 26 Y Y NNP cord-028721-x6f26ahr 53 27 chromosome chromosome NN cord-028721-x6f26ahr 54 1 is be VBZ cord-028721-x6f26ahr 54 2 either either DT cord-028721-x6f26ahr 54 3 46XX 46xx CD cord-028721-x6f26ahr 54 4 SRY+ SRY+ NNP cord-028721-x6f26ahr 54 5 ( ( -LRB- cord-028721-x6f26ahr 54 6 80 80 CD cord-028721-x6f26ahr 54 7 % % NN cord-028721-x6f26ahr 54 8 ) ) -RRB- cord-028721-x6f26ahr 54 9 or or CC cord-028721-x6f26ahr 54 10 46XX 46xx CD cord-028721-x6f26ahr 54 11 SRY− SRY− NNP cord-028721-x6f26ahr 54 12 ( ( -LRB- cord-028721-x6f26ahr 54 13 20 20 CD cord-028721-x6f26ahr 54 14 % % NN cord-028721-x6f26ahr 54 15 ) ) -RRB- cord-028721-x6f26ahr 54 16 , , , cord-028721-x6f26ahr 54 17 and and CC cord-028721-x6f26ahr 54 18 all all DT cord-028721-x6f26ahr 54 19 have have VBP cord-028721-x6f26ahr 54 20 male male JJ cord-028721-x6f26ahr 54 21 external external JJ cord-028721-x6f26ahr 54 22 genitalia genitalia NNS cord-028721-x6f26ahr 54 23 , , , cord-028721-x6f26ahr 54 24 testes testis NNS cord-028721-x6f26ahr 54 25 , , , cord-028721-x6f26ahr 54 26 azoospermia azoospermia NN cord-028721-x6f26ahr 54 27 and and CC cord-028721-x6f26ahr 54 28 no no DT cord-028721-x6f26ahr 54 29 müllerian müllerian JJ cord-028721-x6f26ahr 54 30 structures structure NNS cord-028721-x6f26ahr 54 31 . . . cord-028721-x6f26ahr 55 1 Some some DT cord-028721-x6f26ahr 55 2 46XX 46xx CD cord-028721-x6f26ahr 55 3 SRYpatients srypatient NNS cord-028721-x6f26ahr 55 4 have have VBP cord-028721-x6f26ahr 55 5 SOX-9 sox-9 DT cord-028721-x6f26ahr 55 6 duplication duplication NN cord-028721-x6f26ahr 55 7 . . . cord-028721-x6f26ahr 56 1 16 16 CD cord-028721-x6f26ahr 57 1 Following follow VBG cord-028721-x6f26ahr 57 2 discovery discovery NN cord-028721-x6f26ahr 57 3 of of IN cord-028721-x6f26ahr 57 4 the the DT cord-028721-x6f26ahr 57 5 SRY SRY NNP cord-028721-x6f26ahr 57 6 gene gene NN cord-028721-x6f26ahr 57 7 , , , cord-028721-x6f26ahr 57 8 the the DT cord-028721-x6f26ahr 57 9 knowledge knowledge NN cord-028721-x6f26ahr 57 10 about about IN cord-028721-x6f26ahr 57 11 genes gene NNS cord-028721-x6f26ahr 57 12 involved involve VBN cord-028721-x6f26ahr 57 13 in in IN cord-028721-x6f26ahr 57 14 gonadal gonadal JJ cord-028721-x6f26ahr 57 15 formation formation NN cord-028721-x6f26ahr 57 16 advanced advance VBN cord-028721-x6f26ahr 57 17 experimentally experimentally RB cord-028721-x6f26ahr 57 18 with with IN cord-028721-x6f26ahr 57 19 knockout knockout NN cord-028721-x6f26ahr 57 20 mice mouse NNS cord-028721-x6f26ahr 57 21 and and CC cord-028721-x6f26ahr 57 22 the the DT cord-028721-x6f26ahr 57 23 study study NN cord-028721-x6f26ahr 57 24 of of IN cord-028721-x6f26ahr 57 25 human human JJ cord-028721-x6f26ahr 57 26 syndromes syndrome NNS cord-028721-x6f26ahr 57 27 . . . cord-028721-x6f26ahr 58 1 Now now RB cord-028721-x6f26ahr 58 2 , , , cord-028721-x6f26ahr 58 3 there there EX cord-028721-x6f26ahr 58 4 are be VBP cord-028721-x6f26ahr 58 5 numerous numerous JJ cord-028721-x6f26ahr 58 6 reported report VBN cord-028721-x6f26ahr 58 7 genes gene NNS cord-028721-x6f26ahr 58 8 ( ( -LRB- cord-028721-x6f26ahr 58 9 including include VBG cord-028721-x6f26ahr 58 10 SOX-8 SOX-8 NNP cord-028721-x6f26ahr 58 11 , , , cord-028721-x6f26ahr 58 12 SOX-9 SOX-9 NNP cord-028721-x6f26ahr 58 13 , , , cord-028721-x6f26ahr 58 14 DAX-1 dax-1 JJ cord-028721-x6f26ahr 58 15 , , , cord-028721-x6f26ahr 58 16 LHX-9 LHX-9 NNP cord-028721-x6f26ahr 58 17 , , , cord-028721-x6f26ahr 58 18 LIM-1 LIM-1 NNP cord-028721-x6f26ahr 58 19 and and CC cord-028721-x6f26ahr 58 20 DMRT-1 DMRT-1 NNP cord-028721-x6f26ahr 58 21 ) ) -RRB- cord-028721-x6f26ahr 58 22 that that WDT cord-028721-x6f26ahr 58 23 encode encode VBP cord-028721-x6f26ahr 58 24 associated associated JJ cord-028721-x6f26ahr 58 25 transcription transcription NN cord-028721-x6f26ahr 58 26 factors factor NNS cord-028721-x6f26ahr 58 27 . . . cord-028721-x6f26ahr 59 1 SOX-8 SOX-8 NNP cord-028721-x6f26ahr 59 2 and and CC cord-028721-x6f26ahr 59 3 SOX-9 SOX-9 NNP cord-028721-x6f26ahr 60 1 ( ( -LRB- cord-028721-x6f26ahr 60 2 SRYY SRYY NNP cord-028721-x6f26ahr 60 3 box box NN cord-028721-x6f26ahr 60 4 8 8 CD cord-028721-x6f26ahr 60 5 and and CC cord-028721-x6f26ahr 60 6 9 9 CD cord-028721-x6f26ahr 60 7 or or CC cord-028721-x6f26ahr 60 8 SRY SRY NNP cord-028721-x6f26ahr 60 9 HMG HMG NNP cord-028721-x6f26ahr 60 10 - - HYPH cord-028721-x6f26ahr 60 11 BOX BOX NNP cord-028721-x6f26ahr 60 12 gene gene NN cord-028721-x6f26ahr 60 13 9 9 CD cord-028721-x6f26ahr 60 14 ) ) -RRB- cord-028721-x6f26ahr 60 15 are be VBP cord-028721-x6f26ahr 60 16 related relate VBN cord-028721-x6f26ahr 60 17 to to IN cord-028721-x6f26ahr 60 18 autosomal autosomal JJ cord-028721-x6f26ahr 60 19 genes gene NNS cord-028721-x6f26ahr 60 20 . . . cord-028721-x6f26ahr 61 1 SOX-9 SOX-9 NNP cord-028721-x6f26ahr 61 2 is be VBZ cord-028721-x6f26ahr 61 3 on on IN cord-028721-x6f26ahr 61 4 chromosome chromosome NN cord-028721-x6f26ahr 61 5 17q24,3q25,1 17q24,3q25,1 CD cord-028721-x6f26ahr 61 6 and and CC cord-028721-x6f26ahr 61 7 is be VBZ cord-028721-x6f26ahr 61 8 expressed express VBN cord-028721-x6f26ahr 61 9 after after IN cord-028721-x6f26ahr 61 10 SRY SRY NNP cord-028721-x6f26ahr 61 11 expression expression NN cord-028721-x6f26ahr 61 12 in in IN cord-028721-x6f26ahr 61 13 the the DT cord-028721-x6f26ahr 61 14 same same JJ cord-028721-x6f26ahr 61 15 cell cell NN cord-028721-x6f26ahr 61 16 type type NN cord-028721-x6f26ahr 61 17 ( ( -LRB- cord-028721-x6f26ahr 61 18 the the DT cord-028721-x6f26ahr 61 19 pre pre JJ cord-028721-x6f26ahr 61 20 - - JJ cord-028721-x6f26ahr 61 21 Sertoli sertoli JJ cord-028721-x6f26ahr 61 22 cell cell NN cord-028721-x6f26ahr 61 23 ) ) -RRB- cord-028721-x6f26ahr 61 24 . . . cord-028721-x6f26ahr 62 1 17 17 CD cord-028721-x6f26ahr 63 1 This this DT cord-028721-x6f26ahr 63 2 gene gene NN cord-028721-x6f26ahr 63 3 is be VBZ cord-028721-x6f26ahr 63 4 also also RB cord-028721-x6f26ahr 63 5 essential essential JJ cord-028721-x6f26ahr 63 6 for for IN cord-028721-x6f26ahr 63 7 the the DT cord-028721-x6f26ahr 63 8 development development NN cord-028721-x6f26ahr 63 9 of of IN cord-028721-x6f26ahr 63 10 the the DT cord-028721-x6f26ahr 63 11 cartilaginous cartilaginous JJ cord-028721-x6f26ahr 63 12 extracellular extracellular JJ cord-028721-x6f26ahr 63 13 matrix matrix NN cord-028721-x6f26ahr 63 14 . . . cord-028721-x6f26ahr 64 1 In in IN cord-028721-x6f26ahr 64 2 the the DT cord-028721-x6f26ahr 64 3 mouse mouse NN cord-028721-x6f26ahr 64 4 gonad gonad NN cord-028721-x6f26ahr 64 5 , , , cord-028721-x6f26ahr 64 6 SOX-9 SOX-9 NNP cord-028721-x6f26ahr 64 7 inhibits inhibit VBZ cord-028721-x6f26ahr 64 8 testicular testicular JJ cord-028721-x6f26ahr 64 9 development development NN cord-028721-x6f26ahr 64 10 or or CC cord-028721-x6f26ahr 64 11 Sertoli sertoli JJ cord-028721-x6f26ahr 64 12 cell cell NN cord-028721-x6f26ahr 64 13 marker marker NN cord-028721-x6f26ahr 64 14 expression expression NN cord-028721-x6f26ahr 64 15 , , , cord-028721-x6f26ahr 64 16 and and CC cord-028721-x6f26ahr 64 17 the the DT cord-028721-x6f26ahr 64 18 gonad gonad NN cord-028721-x6f26ahr 64 19 acquires acquire VBZ cord-028721-x6f26ahr 64 20 an an DT cord-028721-x6f26ahr 64 21 ovarian ovarian JJ cord-028721-x6f26ahr 64 22 pattern pattern NN cord-028721-x6f26ahr 64 23 . . . cord-028721-x6f26ahr 65 1 18 18 CD cord-028721-x6f26ahr 65 2 SOX-9 sox-9 JJ cord-028721-x6f26ahr 65 3 haploinsufficiency haploinsufficiency NN cord-028721-x6f26ahr 65 4 ( ( -LRB- cord-028721-x6f26ahr 65 5 loss loss NN cord-028721-x6f26ahr 65 6 of of IN cord-028721-x6f26ahr 65 7 a a DT cord-028721-x6f26ahr 65 8 functional functional JJ cord-028721-x6f26ahr 65 9 allele allele NN cord-028721-x6f26ahr 65 10 ) ) -RRB- cord-028721-x6f26ahr 65 11 causes cause VBZ cord-028721-x6f26ahr 65 12 camptomelic camptomelic NNP cord-028721-x6f26ahr 65 13 dysplasia dysplasia NN cord-028721-x6f26ahr 65 14 ( ( -LRB- cord-028721-x6f26ahr 65 15 a a DT cord-028721-x6f26ahr 65 16 syndrome syndrome NN cord-028721-x6f26ahr 65 17 characterized characterize VBN cord-028721-x6f26ahr 65 18 by by IN cord-028721-x6f26ahr 65 19 abnormal abnormal JJ cord-028721-x6f26ahr 65 20 formation formation NN cord-028721-x6f26ahr 65 21 of of IN cord-028721-x6f26ahr 65 22 cartilage cartilage NN cord-028721-x6f26ahr 65 23 ) ) -RRB- cord-028721-x6f26ahr 65 24 and and CC cord-028721-x6f26ahr 65 25 a a DT cord-028721-x6f26ahr 65 26 46XY 46xy CD cord-028721-x6f26ahr 65 27 constitution constitution NN cord-028721-x6f26ahr 65 28 with with IN cord-028721-x6f26ahr 65 29 female female JJ cord-028721-x6f26ahr 65 30 phenotype phenotype NN cord-028721-x6f26ahr 65 31 , , , cord-028721-x6f26ahr 65 32 17 17 CD cord-028721-x6f26ahr 65 33 , , , cord-028721-x6f26ahr 65 34 19 19 CD cord-028721-x6f26ahr 65 35 whereas whereas IN cord-028721-x6f26ahr 65 36 SOX-9 sox-9 JJ cord-028721-x6f26ahr 65 37 duplication duplication NN cord-028721-x6f26ahr 65 38 results result NNS cord-028721-x6f26ahr 65 39 in in IN cord-028721-x6f26ahr 65 40 46XX 46xx CD cord-028721-x6f26ahr 65 41 patients patient NNS cord-028721-x6f26ahr 65 42 with with IN cord-028721-x6f26ahr 65 43 male male JJ cord-028721-x6f26ahr 65 44 phenotype phenotype NN cord-028721-x6f26ahr 65 45 . . . cord-028721-x6f26ahr 66 1 20 20 CD cord-028721-x6f26ahr 66 2 SOX-8 SOX-8 NNP cord-028721-x6f26ahr 66 3 is be VBZ cord-028721-x6f26ahr 66 4 other other JJ cord-028721-x6f26ahr 66 5 cofactor cofactor NN cord-028721-x6f26ahr 66 6 in in IN cord-028721-x6f26ahr 66 7 AMH amh NN cord-028721-x6f26ahr 66 8 regulation regulation NN cord-028721-x6f26ahr 66 9 and and CC cord-028721-x6f26ahr 66 10 acts act NNS cord-028721-x6f26ahr 66 11 by by IN cord-028721-x6f26ahr 66 12 protein protein NN cord-028721-x6f26ahr 66 13 - - HYPH cord-028721-x6f26ahr 66 14 protein protein NN cord-028721-x6f26ahr 66 15 interaction interaction NN cord-028721-x6f26ahr 66 16 with with IN cord-028721-x6f26ahr 66 17 SF-1 SF-1 NNP cord-028721-x6f26ahr 66 18 . . . cord-028721-x6f26ahr 67 1 Experimental experimental JJ cord-028721-x6f26ahr 67 2 models model NNS cord-028721-x6f26ahr 67 3 show show VBP cord-028721-x6f26ahr 67 4 that that IN cord-028721-x6f26ahr 67 5 SOX-9 sox-9 JJ cord-028721-x6f26ahr 67 6 dysfunction dysfunction NN cord-028721-x6f26ahr 67 7 results result NNS cord-028721-x6f26ahr 67 8 in in IN cord-028721-x6f26ahr 67 9 replacement replacement NN cord-028721-x6f26ahr 67 10 by by IN cord-028721-x6f26ahr 67 11 SOX-8 SOX-8 NNP cord-028721-x6f26ahr 67 12 expression expression NN cord-028721-x6f26ahr 67 13 via via IN cord-028721-x6f26ahr 67 14 a a DT cord-028721-x6f26ahr 67 15 feedback feedback NN cord-028721-x6f26ahr 67 16 mechanism mechanism NN cord-028721-x6f26ahr 67 17 . . . cord-028721-x6f26ahr 68 1 21 21 CD cord-028721-x6f26ahr 68 2 DAX-1 dax-1 JJ cord-028721-x6f26ahr 68 3 ( ( -LRB- cord-028721-x6f26ahr 68 4 dosage dosage NN cord-028721-x6f26ahr 68 5 - - HYPH cord-028721-x6f26ahr 68 6 sensitive sensitive JJ cord-028721-x6f26ahr 68 7 sex sex NN cord-028721-x6f26ahr 68 8 - - HYPH cord-028721-x6f26ahr 68 9 reversal reversal NN cord-028721-x6f26ahr 68 10 , , , cord-028721-x6f26ahr 68 11 adrenal adrenal JJ cord-028721-x6f26ahr 68 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 68 13 , , , cord-028721-x6f26ahr 68 14 X x NN cord-028721-x6f26ahr 68 15 - - HYPH cord-028721-x6f26ahr 68 16 linked link VBN cord-028721-x6f26ahr 68 17 ) ) -RRB- cord-028721-x6f26ahr 68 18 gene gene NN cord-028721-x6f26ahr 68 19 is be VBZ cord-028721-x6f26ahr 68 20 involved involve VBN cord-028721-x6f26ahr 68 21 in in IN cord-028721-x6f26ahr 68 22 the the DT cord-028721-x6f26ahr 68 23 development development NN cord-028721-x6f26ahr 68 24 of of IN cord-028721-x6f26ahr 68 25 testes testis NNS cord-028721-x6f26ahr 68 26 , , , cord-028721-x6f26ahr 68 27 ovaries ovary NNS cord-028721-x6f26ahr 68 28 , , , cord-028721-x6f26ahr 68 29 and and CC cord-028721-x6f26ahr 68 30 adrenal adrenal JJ cord-028721-x6f26ahr 68 31 glands gland NNS cord-028721-x6f26ahr 68 32 . . . cord-028721-x6f26ahr 69 1 DAX-1 dax-1 JJ cord-028721-x6f26ahr 69 2 , , , cord-028721-x6f26ahr 69 3 on on IN cord-028721-x6f26ahr 69 4 X x NN cord-028721-x6f26ahr 69 5 chromosome chromosome NN cord-028721-x6f26ahr 69 6 , , , cord-028721-x6f26ahr 69 7 is be VBZ cord-028721-x6f26ahr 69 8 expressed express VBN cord-028721-x6f26ahr 69 9 during during IN cord-028721-x6f26ahr 69 10 ovarian ovarian JJ cord-028721-x6f26ahr 69 11 formation formation NN cord-028721-x6f26ahr 69 12 and and CC cord-028721-x6f26ahr 69 13 inhibited inhibit VBN cord-028721-x6f26ahr 69 14 by by IN cord-028721-x6f26ahr 69 15 SRY SRY NNP cord-028721-x6f26ahr 69 16 during during IN cord-028721-x6f26ahr 69 17 testicular testicular JJ cord-028721-x6f26ahr 69 18 formation formation NN cord-028721-x6f26ahr 69 19 . . . cord-028721-x6f26ahr 70 1 Duplication duplication NN cord-028721-x6f26ahr 70 2 of of IN cord-028721-x6f26ahr 70 3 the the DT cord-028721-x6f26ahr 70 4 DAX-1 dax-1 JJ cord-028721-x6f26ahr 70 5 region region NN cord-028721-x6f26ahr 70 6 in in IN cord-028721-x6f26ahr 70 7 Xp21 Xp21 NNP cord-028721-x6f26ahr 70 8 results result VBZ cord-028721-x6f26ahr 70 9 in in IN cord-028721-x6f26ahr 70 10 46XY 46xy CD cord-028721-x6f26ahr 70 11 gonadal gonadal JJ cord-028721-x6f26ahr 70 12 dysgenesis dysgenesis NN cord-028721-x6f26ahr 70 13 . . . cord-028721-x6f26ahr 71 1 22 22 CD cord-028721-x6f26ahr 71 2 , , , cord-028721-x6f26ahr 71 3 23 23 CD cord-028721-x6f26ahr 71 4 Conversely conversely RB cord-028721-x6f26ahr 71 5 , , , cord-028721-x6f26ahr 71 6 DAX-1 dax-1 JJ cord-028721-x6f26ahr 71 7 mutations mutation NNS cord-028721-x6f26ahr 71 8 decrease decrease VBP cord-028721-x6f26ahr 71 9 gene gene NN cord-028721-x6f26ahr 71 10 expression expression NN cord-028721-x6f26ahr 71 11 , , , cord-028721-x6f26ahr 71 12 resulting result VBG cord-028721-x6f26ahr 71 13 in in IN cord-028721-x6f26ahr 71 14 absence absence NN cord-028721-x6f26ahr 71 15 of of IN cord-028721-x6f26ahr 71 16 adrenal adrenal JJ cord-028721-x6f26ahr 71 17 cortex cortex NN cord-028721-x6f26ahr 71 18 and and CC cord-028721-x6f26ahr 71 19 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 71 20 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 71 21 ; ; : cord-028721-x6f26ahr 71 22 10 10 CD cord-028721-x6f26ahr 71 23 testicular testicular JJ cord-028721-x6f26ahr 71 24 determination determination NN cord-028721-x6f26ahr 71 25 is be VBZ cord-028721-x6f26ahr 71 26 normal normal JJ cord-028721-x6f26ahr 71 27 . . . cord-028721-x6f26ahr 72 1 Deletions deletion NNS cord-028721-x6f26ahr 72 2 in in IN cord-028721-x6f26ahr 72 3 chromosomes chromosome NNS cord-028721-x6f26ahr 72 4 9p 9p CD cord-028721-x6f26ahr 72 5 24 24 CD cord-028721-x6f26ahr 72 6 and and CC cord-028721-x6f26ahr 72 7 10q 10q CD cord-028721-x6f26ahr 72 8 25 25 CD cord-028721-x6f26ahr 72 9 are be VBP cord-028721-x6f26ahr 72 10 associated associate VBN cord-028721-x6f26ahr 72 11 with with IN cord-028721-x6f26ahr 72 12 the the DT cord-028721-x6f26ahr 72 13 female female JJ cord-028721-x6f26ahr 72 14 phenotype phenotype NN cord-028721-x6f26ahr 72 15 in in IN cord-028721-x6f26ahr 72 16 46XY 46xy CD cord-028721-x6f26ahr 72 17 individuals individual NNS cord-028721-x6f26ahr 72 18 . . . cord-028721-x6f26ahr 73 1 Chromosome chromosome NN cord-028721-x6f26ahr 73 2 9p 9p CD cord-028721-x6f26ahr 73 3 deletions deletion NNS cord-028721-x6f26ahr 73 4 are be VBP cord-028721-x6f26ahr 73 5 also also RB cord-028721-x6f26ahr 73 6 associated associate VBN cord-028721-x6f26ahr 73 7 with with IN cord-028721-x6f26ahr 73 8 facial facial JJ cord-028721-x6f26ahr 73 9 malformations malformation NNS cord-028721-x6f26ahr 73 10 , , , cord-028721-x6f26ahr 73 11 premature premature JJ cord-028721-x6f26ahr 73 12 closure closure NN cord-028721-x6f26ahr 73 13 of of IN cord-028721-x6f26ahr 73 14 the the DT cord-028721-x6f26ahr 73 15 frontal frontal JJ cord-028721-x6f26ahr 73 16 suture suture NN cord-028721-x6f26ahr 73 17 , , , cord-028721-x6f26ahr 73 18 hydronephrosis hydronephrosis NN cord-028721-x6f26ahr 73 19 , , , cord-028721-x6f26ahr 73 20 and and CC cord-028721-x6f26ahr 73 21 delayed delay VBN cord-028721-x6f26ahr 73 22 development development NN cord-028721-x6f26ahr 73 23 . . . cord-028721-x6f26ahr 74 1 Deletions deletion NNS cord-028721-x6f26ahr 74 2 of of IN cord-028721-x6f26ahr 74 3 two two CD cord-028721-x6f26ahr 74 4 genes gene NNS cord-028721-x6f26ahr 74 5 ( ( -LRB- cord-028721-x6f26ahr 74 6 DMRT1 DMRT1 NNP cord-028721-x6f26ahr 74 7 and and CC cord-028721-x6f26ahr 74 8 DMRT2 DMRT2 NNP cord-028721-x6f26ahr 74 9 ) ) -RRB- cord-028721-x6f26ahr 74 10 on on IN cord-028721-x6f26ahr 74 11 chromosome chromosome NN cord-028721-x6f26ahr 74 12 9p24.3 9p24.3 CD cord-028721-x6f26ahr 74 13 may may MD cord-028721-x6f26ahr 74 14 be be VB cord-028721-x6f26ahr 74 15 found find VBN cord-028721-x6f26ahr 74 16 in in IN cord-028721-x6f26ahr 74 17 46XY 46xy CD cord-028721-x6f26ahr 74 18 females female NNS cord-028721-x6f26ahr 74 19 . . . cord-028721-x6f26ahr 75 1 Terminal terminal JJ cord-028721-x6f26ahr 75 2 deletions deletion NNS cord-028721-x6f26ahr 75 3 in in IN cord-028721-x6f26ahr 75 4 chromosome chromosome NN cord-028721-x6f26ahr 75 5 10q 10q NNS cord-028721-x6f26ahr 75 6 are be VBP cord-028721-x6f26ahr 75 7 associated associate VBN cord-028721-x6f26ahr 75 8 with with IN cord-028721-x6f26ahr 75 9 genital genital JJ cord-028721-x6f26ahr 75 10 malformations malformation NNS cord-028721-x6f26ahr 75 11 , , , cord-028721-x6f26ahr 75 12 multiple multiple JJ cord-028721-x6f26ahr 75 13 phenotypic phenotypic JJ cord-028721-x6f26ahr 75 14 anomalies anomaly NNS cord-028721-x6f26ahr 75 15 , , , cord-028721-x6f26ahr 75 16 and and CC cord-028721-x6f26ahr 75 17 mental mental JJ cord-028721-x6f26ahr 75 18 retardation retardation NN cord-028721-x6f26ahr 75 19 . . . cord-028721-x6f26ahr 76 1 In in IN cord-028721-x6f26ahr 76 2 the the DT cord-028721-x6f26ahr 76 3 fourth fourth JJ cord-028721-x6f26ahr 76 4 week week NN cord-028721-x6f26ahr 76 5 of of IN cord-028721-x6f26ahr 76 6 gestation gestation NN cord-028721-x6f26ahr 76 7 , , , cord-028721-x6f26ahr 76 8 the the DT cord-028721-x6f26ahr 76 9 urogenital urogenital JJ cord-028721-x6f26ahr 76 10 ridges ridge NNS cord-028721-x6f26ahr 76 11 appear appear VBP cord-028721-x6f26ahr 76 12 as as IN cord-028721-x6f26ahr 76 13 two two CD cord-028721-x6f26ahr 76 14 parallel parallel JJ cord-028721-x6f26ahr 76 15 prominences prominence NNS cord-028721-x6f26ahr 76 16 along along IN cord-028721-x6f26ahr 76 17 the the DT cord-028721-x6f26ahr 76 18 posterior posterior JJ cord-028721-x6f26ahr 76 19 abdominal abdominal JJ cord-028721-x6f26ahr 76 20 wall wall NN cord-028721-x6f26ahr 76 21 . . . cord-028721-x6f26ahr 77 1 These these DT cord-028721-x6f26ahr 77 2 give give VBP cord-028721-x6f26ahr 77 3 rise rise NN cord-028721-x6f26ahr 77 4 to to IN cord-028721-x6f26ahr 77 5 two two CD cord-028721-x6f26ahr 77 6 important important JJ cord-028721-x6f26ahr 77 7 pairs pair NNS cord-028721-x6f26ahr 77 8 of of IN cord-028721-x6f26ahr 77 9 structures structure NNS cord-028721-x6f26ahr 77 10 : : : cord-028721-x6f26ahr 77 11 the the DT cord-028721-x6f26ahr 77 12 genital genital JJ cord-028721-x6f26ahr 77 13 ridges ridge NNS cord-028721-x6f26ahr 77 14 arising arise VBG cord-028721-x6f26ahr 77 15 from from IN cord-028721-x6f26ahr 77 16 the the DT cord-028721-x6f26ahr 77 17 medial medial JJ cord-028721-x6f26ahr 77 18 prominences prominence NNS cord-028721-x6f26ahr 77 19 , , , cord-028721-x6f26ahr 77 20 and and CC cord-028721-x6f26ahr 77 21 the the DT cord-028721-x6f26ahr 77 22 mesonephric mesonephric JJ cord-028721-x6f26ahr 77 23 ridges ridge NNS cord-028721-x6f26ahr 77 24 from from IN cord-028721-x6f26ahr 77 25 the the DT cord-028721-x6f26ahr 77 26 lateral lateral JJ cord-028721-x6f26ahr 77 27 prominences prominence NNS cord-028721-x6f26ahr 77 28 . . . cord-028721-x6f26ahr 78 1 The the DT cord-028721-x6f26ahr 78 2 genital genital JJ cord-028721-x6f26ahr 78 3 ridges ridge NNS cord-028721-x6f26ahr 78 4 are be VBP cord-028721-x6f26ahr 78 5 the the DT cord-028721-x6f26ahr 78 6 fi fi NN cord-028721-x6f26ahr 78 7 rst rst NN cord-028721-x6f26ahr 78 8 primordium primordium NN cord-028721-x6f26ahr 78 9 of of IN cord-028721-x6f26ahr 78 10 the the DT cord-028721-x6f26ahr 78 11 gonad gonad NN cord-028721-x6f26ahr 78 12 and and CC cord-028721-x6f26ahr 78 13 stand stand VB cord-028721-x6f26ahr 78 14 out out RP cord-028721-x6f26ahr 78 15 as as IN cord-028721-x6f26ahr 78 16 a a DT cord-028721-x6f26ahr 78 17 pair pair NN cord-028721-x6f26ahr 78 18 of of IN cord-028721-x6f26ahr 78 19 prominences prominence NNS cord-028721-x6f26ahr 78 20 about about IN cord-028721-x6f26ahr 78 21 the the DT cord-028721-x6f26ahr 78 22 midline midline NN cord-028721-x6f26ahr 78 23 . . . cord-028721-x6f26ahr 79 1 In in IN cord-028721-x6f26ahr 79 2 30 30 CD cord-028721-x6f26ahr 79 3 - - SYM cord-028721-x6f26ahr 79 4 32-day 32-day CD cord-028721-x6f26ahr 79 5 embryos embryo NNS cord-028721-x6f26ahr 79 6 , , , cord-028721-x6f26ahr 79 7 each each DT cord-028721-x6f26ahr 79 8 genital genital JJ cord-028721-x6f26ahr 79 9 ridge ridge NN cord-028721-x6f26ahr 79 10 is be VBZ cord-028721-x6f26ahr 79 11 lateral lateral JJ cord-028721-x6f26ahr 79 12 to to IN cord-028721-x6f26ahr 79 13 the the DT cord-028721-x6f26ahr 79 14 aorta aorta NN cord-028721-x6f26ahr 79 15 and and CC cord-028721-x6f26ahr 79 16 medial medial JJ cord-028721-x6f26ahr 79 17 to to IN cord-028721-x6f26ahr 79 18 the the DT cord-028721-x6f26ahr 79 19 mesonephric mesonephric JJ cord-028721-x6f26ahr 79 20 duct duct NN cord-028721-x6f26ahr 79 21 ( ( -LRB- cord-028721-x6f26ahr 79 22 Fig Fig NNP cord-028721-x6f26ahr 79 23 . . . cord-028721-x6f26ahr 79 24 12 12 CD cord-028721-x6f26ahr 79 25 - - SYM cord-028721-x6f26ahr 79 26 2 2 CD cord-028721-x6f26ahr 79 27 ) ) -RRB- cord-028721-x6f26ahr 79 28 . . . cord-028721-x6f26ahr 80 1 The the DT cord-028721-x6f26ahr 80 2 celomic celomic JJ cord-028721-x6f26ahr 80 3 epithelium epithelium NN cord-028721-x6f26ahr 80 4 forming form VBG cord-028721-x6f26ahr 80 5 the the DT cord-028721-x6f26ahr 80 6 genital genital JJ cord-028721-x6f26ahr 80 7 ridges ridge NNS cord-028721-x6f26ahr 80 8 grows grow VBZ cord-028721-x6f26ahr 80 9 as as IN cord-028721-x6f26ahr 80 10 cordlike cordlike NN cord-028721-x6f26ahr 80 11 structures structure NNS cord-028721-x6f26ahr 80 12 to to TO cord-028721-x6f26ahr 80 13 create create VB cord-028721-x6f26ahr 80 14 the the DT cord-028721-x6f26ahr 80 15 primary primary JJ cord-028721-x6f26ahr 80 16 sex sex NN cord-028721-x6f26ahr 80 17 cords cord NNS cord-028721-x6f26ahr 80 18 . . . cord-028721-x6f26ahr 81 1 Immediately immediately RB cord-028721-x6f26ahr 81 2 beneath beneath IN cord-028721-x6f26ahr 81 3 the the DT cord-028721-x6f26ahr 81 4 celomic celomic JJ cord-028721-x6f26ahr 81 5 epithelium epithelium NN cord-028721-x6f26ahr 81 6 there there EX cord-028721-x6f26ahr 81 7 are be VBP cord-028721-x6f26ahr 81 8 several several JJ cord-028721-x6f26ahr 81 9 mesonephric mesonephric JJ cord-028721-x6f26ahr 81 10 ductuli ductuli NNS cord-028721-x6f26ahr 81 11 and and CC cord-028721-x6f26ahr 81 12 glomeruli glomeruli NNP cord-028721-x6f26ahr 82 1 ( ( -LRB- cord-028721-x6f26ahr 82 2 Fig Fig NNP cord-028721-x6f26ahr 82 3 . . . cord-028721-x6f26ahr 82 4 12 12 CD cord-028721-x6f26ahr 82 5 - - SYM cord-028721-x6f26ahr 82 6 3 3 CD cord-028721-x6f26ahr 82 7 ) ) -RRB- cord-028721-x6f26ahr 82 8 . . . cord-028721-x6f26ahr 83 1 The the DT cord-028721-x6f26ahr 83 2 origin origin NN cord-028721-x6f26ahr 83 3 of of IN cord-028721-x6f26ahr 83 4 the the DT cord-028721-x6f26ahr 83 5 gonadal gonadal JJ cord-028721-x6f26ahr 83 6 blastema blastema JJ cord-028721-x6f26ahr 83 7 results result VBZ cord-028721-x6f26ahr 83 8 from from IN cord-028721-x6f26ahr 83 9 the the DT cord-028721-x6f26ahr 83 10 junction junction NN cord-028721-x6f26ahr 83 11 of of IN cord-028721-x6f26ahr 83 12 two two CD cord-028721-x6f26ahr 83 13 cell cell NN cord-028721-x6f26ahr 83 14 types type NNS cord-028721-x6f26ahr 83 15 : : : cord-028721-x6f26ahr 83 16 epithelial epithelial JJ cord-028721-x6f26ahr 83 17 cells cell NNS cord-028721-x6f26ahr 83 18 from from IN cord-028721-x6f26ahr 83 19 the the DT cord-028721-x6f26ahr 83 20 celomic celomic JJ cord-028721-x6f26ahr 83 21 epithelium epithelium NN cord-028721-x6f26ahr 83 22 and and CC cord-028721-x6f26ahr 83 23 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 83 24 cells cell NNS cord-028721-x6f26ahr 83 25 from from IN cord-028721-x6f26ahr 83 26 the the DT cord-028721-x6f26ahr 83 27 mesonephric mesonephric JJ cord-028721-x6f26ahr 83 28 region region NN cord-028721-x6f26ahr 83 29 , , , cord-028721-x6f26ahr 83 30 26,27 26,27 CD cord-028721-x6f26ahr 83 31 although although IN cord-028721-x6f26ahr 83 32 experimental experimental JJ cord-028721-x6f26ahr 83 33 data datum NNS cord-028721-x6f26ahr 83 34 are be VBP cord-028721-x6f26ahr 83 35 confl confl NN cord-028721-x6f26ahr 83 36 icting icting NN cord-028721-x6f26ahr 83 37 . . . cord-028721-x6f26ahr 84 1 One one CD cord-028721-x6f26ahr 84 2 of of IN cord-028721-x6f26ahr 84 3 the the DT cord-028721-x6f26ahr 84 4 earliest early JJS cord-028721-x6f26ahr 84 5 effects effect NNS cord-028721-x6f26ahr 84 6 of of IN cord-028721-x6f26ahr 84 7 SRY sry JJ cord-028721-x6f26ahr 84 8 expression expression NN cord-028721-x6f26ahr 84 9 is be VBZ cord-028721-x6f26ahr 84 10 induction induction NN cord-028721-x6f26ahr 84 11 of of IN cord-028721-x6f26ahr 84 12 mesonephric mesonephric JJ cord-028721-x6f26ahr 84 13 cell cell NN cord-028721-x6f26ahr 84 14 migration migration NN cord-028721-x6f26ahr 84 15 toward toward IN cord-028721-x6f26ahr 84 16 the the DT cord-028721-x6f26ahr 84 17 genital genital JJ cord-028721-x6f26ahr 84 18 ridge ridge NN cord-028721-x6f26ahr 84 19 . . . cord-028721-x6f26ahr 85 1 28 28 CD cord-028721-x6f26ahr 85 2 , , , cord-028721-x6f26ahr 85 3 29 29 CD cord-028721-x6f26ahr 85 4 Histochemical Histochemical NNP cord-028721-x6f26ahr 85 5 studies study NNS cord-028721-x6f26ahr 85 6 revealed reveal VBD cord-028721-x6f26ahr 85 7 that that IN cord-028721-x6f26ahr 85 8 an an DT cord-028721-x6f26ahr 85 9 early early JJ cord-028721-x6f26ahr 85 10 event event NN cord-028721-x6f26ahr 85 11 is be VBZ cord-028721-x6f26ahr 85 12 also also RB cord-028721-x6f26ahr 85 13 disruption disruption NN cord-028721-x6f26ahr 85 14 of of IN cord-028721-x6f26ahr 85 15 the the DT cord-028721-x6f26ahr 85 16 celomic celomic JJ cord-028721-x6f26ahr 85 17 epithelium epithelium NN cord-028721-x6f26ahr 85 18 basal basal NN cord-028721-x6f26ahr 85 19 lamina lamina NN cord-028721-x6f26ahr 85 20 , , , cord-028721-x6f26ahr 85 21 permitting permit VBG cord-028721-x6f26ahr 85 22 the the DT cord-028721-x6f26ahr 85 23 migration migration NN cord-028721-x6f26ahr 85 24 of of IN cord-028721-x6f26ahr 85 25 these these DT cord-028721-x6f26ahr 85 26 epithelial epithelial JJ cord-028721-x6f26ahr 85 27 cells cell NNS cord-028721-x6f26ahr 85 28 inside inside IN cord-028721-x6f26ahr 85 29 the the DT cord-028721-x6f26ahr 85 30 gonad gonad NN cord-028721-x6f26ahr 85 31 . . . cord-028721-x6f26ahr 86 1 If if IN cord-028721-x6f26ahr 86 2 chromosomal chromosomal JJ cord-028721-x6f26ahr 86 3 constitution constitution NN cord-028721-x6f26ahr 86 4 is be VBZ cord-028721-x6f26ahr 86 5 XY XY NNP cord-028721-x6f26ahr 86 6 , , , cord-028721-x6f26ahr 86 7 these these DT cord-028721-x6f26ahr 86 8 cells cell NNS cord-028721-x6f26ahr 86 9 give give VBP cord-028721-x6f26ahr 86 10 rise rise NN cord-028721-x6f26ahr 86 11 to to IN cord-028721-x6f26ahr 86 12 Sertoli sertoli JJ cord-028721-x6f26ahr 86 13 cells cell NNS cord-028721-x6f26ahr 86 14 . . . cord-028721-x6f26ahr 87 1 30 30 CD cord-028721-x6f26ahr 87 2 Cells cell NNS cord-028721-x6f26ahr 87 3 derived derive VBN cord-028721-x6f26ahr 87 4 from from IN cord-028721-x6f26ahr 87 5 the the DT cord-028721-x6f26ahr 87 6 celomic celomic JJ cord-028721-x6f26ahr 87 7 epithelium epithelium NN cord-028721-x6f26ahr 87 8 are be VBP cord-028721-x6f26ahr 87 9 recognized recognize VBN cord-028721-x6f26ahr 87 10 by by IN cord-028721-x6f26ahr 87 11 their -PRON- PRP$ cord-028721-x6f26ahr 87 12 pale pale JJ cord-028721-x6f26ahr 87 13 cytoplasm cytoplasm NN cord-028721-x6f26ahr 87 14 , , , cord-028721-x6f26ahr 87 15 large large JJ cord-028721-x6f26ahr 87 16 size size NN cord-028721-x6f26ahr 87 17 , , , cord-028721-x6f26ahr 87 18 Embryology embryology NN cord-028721-x6f26ahr 87 19 and and CC cord-028721-x6f26ahr 87 20 anatomy anatomy NN cord-028721-x6f26ahr 87 21 of of IN cord-028721-x6f26ahr 87 22 the the DT cord-028721-x6f26ahr 87 23 testis testis NN cord-028721-x6f26ahr 88 1 The the DT cord-028721-x6f26ahr 88 2 rete rete NN cord-028721-x6f26ahr 88 3 testis testis NN cord-028721-x6f26ahr 88 4 originates originate VBZ cord-028721-x6f26ahr 88 5 from from IN cord-028721-x6f26ahr 88 6 mesonephric mesonephric JJ cord-028721-x6f26ahr 88 7 remnants remnant NNS cord-028721-x6f26ahr 88 8 of of IN cord-028721-x6f26ahr 88 9 sex sex NN cord-028721-x6f26ahr 88 10 cords cord NNS cord-028721-x6f26ahr 88 11 that that WDT cord-028721-x6f26ahr 88 12 are be VBP cord-028721-x6f26ahr 88 13 in in IN cord-028721-x6f26ahr 88 14 continuity continuity NN cord-028721-x6f26ahr 88 15 with with IN cord-028721-x6f26ahr 88 16 the the DT cord-028721-x6f26ahr 88 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 88 18 cords cord NNS cord-028721-x6f26ahr 88 19 . . . cord-028721-x6f26ahr 89 1 The the DT cord-028721-x6f26ahr 89 2 connection connection NN cord-028721-x6f26ahr 89 3 between between IN cord-028721-x6f26ahr 89 4 the the DT cord-028721-x6f26ahr 89 5 testis testis NN cord-028721-x6f26ahr 89 6 and and CC cord-028721-x6f26ahr 89 7 the the DT cord-028721-x6f26ahr 89 8 mesonephros mesonephros NNP cord-028721-x6f26ahr 89 9 becomes become VBZ cord-028721-x6f26ahr 89 10 progressively progressively RB cord-028721-x6f26ahr 89 11 thinner thin JJR cord-028721-x6f26ahr 90 1 ( ( -LRB- cord-028721-x6f26ahr 90 2 Fig Fig NNP cord-028721-x6f26ahr 90 3 . . . cord-028721-x6f26ahr 90 4 12 12 CD cord-028721-x6f26ahr 90 5 - - SYM cord-028721-x6f26ahr 90 6 4 4 CD cord-028721-x6f26ahr 90 7 ) ) -RRB- cord-028721-x6f26ahr 90 8 . . . cord-028721-x6f26ahr 91 1 The the DT cord-028721-x6f26ahr 91 2 testis testis NN cord-028721-x6f26ahr 91 3 has have VBZ cord-028721-x6f26ahr 91 4 a a DT cord-028721-x6f26ahr 91 5 round round JJ cord-028721-x6f26ahr 91 6 transversal transversal JJ cord-028721-x6f26ahr 91 7 section section NN cord-028721-x6f26ahr 91 8 , , , cord-028721-x6f26ahr 91 9 and and CC cord-028721-x6f26ahr 91 10 remains remain VBZ cord-028721-x6f26ahr 91 11 located locate VBN cord-028721-x6f26ahr 91 12 between between IN cord-028721-x6f26ahr 91 13 two two CD cord-028721-x6f26ahr 91 14 suspensory suspensory JJ cord-028721-x6f26ahr 91 15 ligaments ligament NNS cord-028721-x6f26ahr 91 16 : : : cord-028721-x6f26ahr 91 17 the the DT cord-028721-x6f26ahr 91 18 cranial cranial NN cord-028721-x6f26ahr 91 19 and and CC cord-028721-x6f26ahr 91 20 the the DT cord-028721-x6f26ahr 91 21 caudal caudal NN cord-028721-x6f26ahr 91 22 , , , cord-028721-x6f26ahr 91 23 the the DT cord-028721-x6f26ahr 91 24 latter latter JJ cord-028721-x6f26ahr 91 25 of of IN cord-028721-x6f26ahr 91 26 which which WDT cord-028721-x6f26ahr 91 27 gives give VBZ cord-028721-x6f26ahr 91 28 rise rise NN cord-028721-x6f26ahr 91 29 to to IN cord-028721-x6f26ahr 91 30 the the DT cord-028721-x6f26ahr 91 31 gubernaculum gubernaculum NN cord-028721-x6f26ahr 91 32 . . . cord-028721-x6f26ahr 92 1 The the DT cord-028721-x6f26ahr 92 2 development development NN cord-028721-x6f26ahr 92 3 of of IN cord-028721-x6f26ahr 92 4 the the DT cord-028721-x6f26ahr 92 5 urogenital urogenital JJ cord-028721-x6f26ahr 92 6 tract tract NN cord-028721-x6f26ahr 92 7 begins begin VBZ cord-028721-x6f26ahr 92 8 at at IN cord-028721-x6f26ahr 92 9 the the DT cord-028721-x6f26ahr 92 10 stage stage NN cord-028721-x6f26ahr 92 11 of of IN cord-028721-x6f26ahr 92 12 the the DT cord-028721-x6f26ahr 92 13 undifferentiated undifferentiated JJ cord-028721-x6f26ahr 92 14 gonad gonad NN cord-028721-x6f26ahr 92 15 , , , cord-028721-x6f26ahr 92 16 with with IN cord-028721-x6f26ahr 92 17 the the DT cord-028721-x6f26ahr 92 18 appearance appearance NN cord-028721-x6f26ahr 92 19 of of IN cord-028721-x6f26ahr 92 20 two two CD cord-028721-x6f26ahr 92 21 different different JJ cord-028721-x6f26ahr 92 22 pairs pair NNS cord-028721-x6f26ahr 92 23 of of IN cord-028721-x6f26ahr 92 24 ducts duct NNS cord-028721-x6f26ahr 92 25 : : : cord-028721-x6f26ahr 92 26 the the DT cord-028721-x6f26ahr 92 27 wolffi wolffi NNP cord-028721-x6f26ahr 92 28 an an NNP cord-028721-x6f26ahr 92 29 and and CC cord-028721-x6f26ahr 92 30 the the DT cord-028721-x6f26ahr 92 31 müllerian müllerian NN cord-028721-x6f26ahr 92 32 . . . cord-028721-x6f26ahr 93 1 The the DT cord-028721-x6f26ahr 93 2 wolffi wolffi NN cord-028721-x6f26ahr 93 3 an an DT cord-028721-x6f26ahr 93 4 ducts duct NNS cord-028721-x6f26ahr 93 5 are be VBP cord-028721-x6f26ahr 93 6 formed form VBN cord-028721-x6f26ahr 93 7 in in IN cord-028721-x6f26ahr 93 8 the the DT cord-028721-x6f26ahr 93 9 mesonephros mesonephro NNS cord-028721-x6f26ahr 93 10 in in IN cord-028721-x6f26ahr 93 11 the the DT cord-028721-x6f26ahr 93 12 third third JJ cord-028721-x6f26ahr 93 13 week week NN cord-028721-x6f26ahr 93 14 of of IN cord-028721-x6f26ahr 93 15 gestation gestation NN cord-028721-x6f26ahr 93 16 , , , cord-028721-x6f26ahr 93 17 when when WRB cord-028721-x6f26ahr 93 18 the the DT cord-028721-x6f26ahr 93 19 cranial cranial JJ cord-028721-x6f26ahr 93 20 region region NN cord-028721-x6f26ahr 93 21 of of IN cord-028721-x6f26ahr 93 22 the the DT cord-028721-x6f26ahr 93 23 segmented segmented JJ cord-028721-x6f26ahr 93 24 intermediate intermediate JJ cord-028721-x6f26ahr 93 25 mesoderm mesoderm NNS cord-028721-x6f26ahr 93 26 gives give VBZ cord-028721-x6f26ahr 93 27 rise rise NN cord-028721-x6f26ahr 93 28 to to IN cord-028721-x6f26ahr 93 29 10 10 CD cord-028721-x6f26ahr 93 30 pairs pair NNS cord-028721-x6f26ahr 93 31 of of IN cord-028721-x6f26ahr 93 32 tubules tubule NNS cord-028721-x6f26ahr 93 33 ( ( -LRB- cord-028721-x6f26ahr 93 34 the the DT cord-028721-x6f26ahr 93 35 nephric nephric NNP cord-028721-x6f26ahr 93 36 tubules tubule NNS cord-028721-x6f26ahr 93 37 ) ) -RRB- cord-028721-x6f26ahr 93 38 that that WDT cord-028721-x6f26ahr 93 39 are be VBP cord-028721-x6f26ahr 93 40 metamerically metamerically RB cord-028721-x6f26ahr 93 41 arranged arrange VBN cord-028721-x6f26ahr 93 42 . . . cord-028721-x6f26ahr 94 1 These these DT cord-028721-x6f26ahr 94 2 tubules tubule NNS cord-028721-x6f26ahr 94 3 form form VBP cord-028721-x6f26ahr 94 4 the the DT cord-028721-x6f26ahr 94 5 pronephros pronephro NNS cord-028721-x6f26ahr 94 6 . . . cord-028721-x6f26ahr 95 1 On on IN cord-028721-x6f26ahr 95 2 each each DT cord-028721-x6f26ahr 95 3 side side NN cord-028721-x6f26ahr 95 4 of of IN cord-028721-x6f26ahr 95 5 the the DT cord-028721-x6f26ahr 95 6 body body NN cord-028721-x6f26ahr 95 7 , , , cord-028721-x6f26ahr 95 8 the the DT cord-028721-x6f26ahr 95 9 tubules tubule NNS cord-028721-x6f26ahr 95 10 converge converge VBP cord-028721-x6f26ahr 95 11 to to TO cord-028721-x6f26ahr 95 12 form form VB cord-028721-x6f26ahr 95 13 a a DT cord-028721-x6f26ahr 95 14 longitudinal longitudinal JJ cord-028721-x6f26ahr 95 15 duct duct NN cord-028721-x6f26ahr 95 16 that that WDT cord-028721-x6f26ahr 95 17 opens open VBZ cord-028721-x6f26ahr 95 18 in in IN cord-028721-x6f26ahr 95 19 the the DT cord-028721-x6f26ahr 95 20 celomic celomic JJ cord-028721-x6f26ahr 95 21 cavity cavity NN cord-028721-x6f26ahr 95 22 . . . cord-028721-x6f26ahr 96 1 In in IN cord-028721-x6f26ahr 96 2 the the DT cord-028721-x6f26ahr 96 3 fourth fourth JJ cord-028721-x6f26ahr 96 4 week week NN cord-028721-x6f26ahr 96 5 , , , cord-028721-x6f26ahr 96 6 the the DT cord-028721-x6f26ahr 96 7 pronephros pronephros NNP cord-028721-x6f26ahr 96 8 disappears disappear VBZ cord-028721-x6f26ahr 96 9 and and CC cord-028721-x6f26ahr 96 10 is be VBZ cord-028721-x6f26ahr 96 11 replaced replace VBN cord-028721-x6f26ahr 96 12 by by IN cord-028721-x6f26ahr 96 13 another another DT cord-028721-x6f26ahr 96 14 tubular tubular JJ cord-028721-x6f26ahr 96 15 system system NN cord-028721-x6f26ahr 96 16 ( ( -LRB- cord-028721-x6f26ahr 96 17 derived derive VBN cord-028721-x6f26ahr 96 18 from from IN cord-028721-x6f26ahr 96 19 the the DT cord-028721-x6f26ahr 96 20 intermediate intermediate JJ cord-028721-x6f26ahr 96 21 mesoderm mesoderm NNS cord-028721-x6f26ahr 96 22 , , , cord-028721-x6f26ahr 96 23 which which WDT cord-028721-x6f26ahr 96 24 is be VBZ cord-028721-x6f26ahr 96 25 not not RB cord-028721-x6f26ahr 96 26 segmented segmented JJ cord-028721-x6f26ahr 96 27 ) ) -RRB- cord-028721-x6f26ahr 96 28 that that WDT cord-028721-x6f26ahr 96 29 forms form VBZ cord-028721-x6f26ahr 96 30 the the DT cord-028721-x6f26ahr 96 31 mesonephros mesonephro NNS cord-028721-x6f26ahr 96 32 . . . cord-028721-x6f26ahr 97 1 The the DT cord-028721-x6f26ahr 97 2 medial medial JJ cord-028721-x6f26ahr 97 3 ends end NNS cord-028721-x6f26ahr 97 4 of of IN cord-028721-x6f26ahr 97 5 the the DT cord-028721-x6f26ahr 97 6 mesonephric mesonephric JJ cord-028721-x6f26ahr 97 7 tubules tubule NNS cord-028721-x6f26ahr 97 8 do do VBP cord-028721-x6f26ahr 97 9 not not RB cord-028721-x6f26ahr 97 10 open open VB cord-028721-x6f26ahr 97 11 to to IN cord-028721-x6f26ahr 97 12 the the DT cord-028721-x6f26ahr 97 13 celomic celomic JJ cord-028721-x6f26ahr 97 14 cavity cavity NN cord-028721-x6f26ahr 97 15 but but CC cord-028721-x6f26ahr 97 16 are be VBP cord-028721-x6f26ahr 97 17 connected connect VBN cord-028721-x6f26ahr 97 18 to to IN cord-028721-x6f26ahr 97 19 glomeruli glomerulus NNS cord-028721-x6f26ahr 97 20 at at IN cord-028721-x6f26ahr 97 21 one one CD cord-028721-x6f26ahr 97 22 end end NN cord-028721-x6f26ahr 97 23 and and CC cord-028721-x6f26ahr 97 24 the the DT cord-028721-x6f26ahr 97 25 wolffi wolffi NN cord-028721-x6f26ahr 97 26 an an DT cord-028721-x6f26ahr 97 27 duct duct NN cord-028721-x6f26ahr 97 28 at at IN cord-028721-x6f26ahr 97 29 the the DT cord-028721-x6f26ahr 97 30 other other JJ cord-028721-x6f26ahr 97 31 . . . cord-028721-x6f26ahr 98 1 At at IN cord-028721-x6f26ahr 98 2 the the DT cord-028721-x6f26ahr 98 3 end end NN cord-028721-x6f26ahr 98 4 of of IN cord-028721-x6f26ahr 98 5 the the DT cord-028721-x6f26ahr 98 6 second second JJ cord-028721-x6f26ahr 98 7 month month NN cord-028721-x6f26ahr 98 8 of of IN cord-028721-x6f26ahr 98 9 gestation gestation NN cord-028721-x6f26ahr 98 10 , , , cord-028721-x6f26ahr 98 11 the the DT cord-028721-x6f26ahr 98 12 mesonephros mesonephros NNP cord-028721-x6f26ahr 98 13 is be VBZ cord-028721-x6f26ahr 98 14 replaced replace VBN cord-028721-x6f26ahr 98 15 by by IN cord-028721-x6f26ahr 98 16 the the DT cord-028721-x6f26ahr 98 17 metanephros metanephros NNP cord-028721-x6f26ahr 98 18 or or CC cord-028721-x6f26ahr 98 19 defi defi NNP cord-028721-x6f26ahr 98 20 nitive nitive JJ cord-028721-x6f26ahr 98 21 kidney kidney NN cord-028721-x6f26ahr 98 22 . . . cord-028721-x6f26ahr 99 1 However however RB cord-028721-x6f26ahr 99 2 , , , cord-028721-x6f26ahr 99 3 in in IN cord-028721-x6f26ahr 99 4 the the DT cord-028721-x6f26ahr 99 5 male male NN cord-028721-x6f26ahr 99 6 , , , cord-028721-x6f26ahr 99 7 the the DT cord-028721-x6f26ahr 99 8 most most RBS cord-028721-x6f26ahr 99 9 caudal caudal JJ cord-028721-x6f26ahr 99 10 mesonephric mesonephric JJ cord-028721-x6f26ahr 99 11 tubules tubule NNS cord-028721-x6f26ahr 99 12 and and CC cord-028721-x6f26ahr 99 13 the the DT cord-028721-x6f26ahr 99 14 wolffi wolffi NN cord-028721-x6f26ahr 99 15 an an DT cord-028721-x6f26ahr 99 16 duct duct NN cord-028721-x6f26ahr 99 17 persist persist VB cord-028721-x6f26ahr 99 18 . . . cord-028721-x6f26ahr 100 1 The the DT cord-028721-x6f26ahr 100 2 former former JJ cord-028721-x6f26ahr 100 3 give give NN cord-028721-x6f26ahr 100 4 rise rise NN cord-028721-x6f26ahr 100 5 to to IN cord-028721-x6f26ahr 100 6 the the DT cord-028721-x6f26ahr 100 7 ductuli ductuli NNP cord-028721-x6f26ahr 100 8 efferentes efferentes NNP cord-028721-x6f26ahr 100 9 , , , cord-028721-x6f26ahr 100 10 and and CC cord-028721-x6f26ahr 100 11 the the DT cord-028721-x6f26ahr 100 12 latter latter JJ cord-028721-x6f26ahr 100 13 forms form VBZ cord-028721-x6f26ahr 100 14 the the DT cord-028721-x6f26ahr 100 15 ductus ductus NNP cord-028721-x6f26ahr 100 16 epididymidis epididymidis NN cord-028721-x6f26ahr 100 17 , , , cord-028721-x6f26ahr 100 18 the the DT cord-028721-x6f26ahr 100 19 ductus ductus NN cord-028721-x6f26ahr 100 20 deferens deferen NNS cord-028721-x6f26ahr 100 21 , , , cord-028721-x6f26ahr 100 22 the the DT cord-028721-x6f26ahr 100 23 seminal seminal JJ cord-028721-x6f26ahr 100 24 vesicle vesicle NN cord-028721-x6f26ahr 100 25 , , , cord-028721-x6f26ahr 100 26 and and CC cord-028721-x6f26ahr 100 27 the the DT cord-028721-x6f26ahr 100 28 ejaculatory ejaculatory NN cord-028721-x6f26ahr 100 29 duct duct NN cord-028721-x6f26ahr 100 30 . . . cord-028721-x6f26ahr 101 1 Both both DT cord-028721-x6f26ahr 101 2 müllerian müllerian JJ cord-028721-x6f26ahr 101 3 ducts duct NNS cord-028721-x6f26ahr 101 4 originate originate VBP cord-028721-x6f26ahr 101 5 from from IN cord-028721-x6f26ahr 101 6 a a DT cord-028721-x6f26ahr 101 7 longitudinal longitudinal JJ cord-028721-x6f26ahr 101 8 invagination invagination NN cord-028721-x6f26ahr 101 9 of of IN cord-028721-x6f26ahr 101 10 the the DT cord-028721-x6f26ahr 101 11 celomic celomic JJ cord-028721-x6f26ahr 101 12 epithelium epithelium NN cord-028721-x6f26ahr 101 13 in in IN cord-028721-x6f26ahr 101 14 the the DT cord-028721-x6f26ahr 101 15 anterolateral anterolateral JJ cord-028721-x6f26ahr 101 16 aspect aspect NN cord-028721-x6f26ahr 101 17 of of IN cord-028721-x6f26ahr 101 18 the the DT cord-028721-x6f26ahr 101 19 genital genital JJ cord-028721-x6f26ahr 101 20 ridge ridge NN cord-028721-x6f26ahr 101 21 . . . cord-028721-x6f26ahr 102 1 The the DT cord-028721-x6f26ahr 102 2 cranial cranial JJ cord-028721-x6f26ahr 102 3 end end NN cord-028721-x6f26ahr 102 4 of of IN cord-028721-x6f26ahr 102 5 each each DT cord-028721-x6f26ahr 102 6 duct duct NN cord-028721-x6f26ahr 102 7 is be VBZ cord-028721-x6f26ahr 102 8 a a DT cord-028721-x6f26ahr 102 9 funnel funnel NN cord-028721-x6f26ahr 102 10 that that WDT cord-028721-x6f26ahr 102 11 opens open VBZ cord-028721-x6f26ahr 102 12 in in IN cord-028721-x6f26ahr 102 13 the the DT cord-028721-x6f26ahr 102 14 celomic celomic JJ cord-028721-x6f26ahr 102 15 cavity cavity NN cord-028721-x6f26ahr 102 16 . . . cord-028721-x6f26ahr 103 1 Each each DT cord-028721-x6f26ahr 103 2 duct duct NN cord-028721-x6f26ahr 103 3 runs run VBZ cord-028721-x6f26ahr 103 4 parallel parallel JJ cord-028721-x6f26ahr 103 5 and and CC cord-028721-x6f26ahr 103 6 lateral lateral JJ cord-028721-x6f26ahr 103 7 to to IN cord-028721-x6f26ahr 103 8 the the DT cord-028721-x6f26ahr 103 9 respective respective JJ cord-028721-x6f26ahr 103 10 wolffi wolffi NN cord-028721-x6f26ahr 103 11 an an DT cord-028721-x6f26ahr 103 12 duct duct NN cord-028721-x6f26ahr 103 13 and and CC cord-028721-x6f26ahr 103 14 , , , cord-028721-x6f26ahr 103 15 as as IN cord-028721-x6f26ahr 103 16 they -PRON- PRP cord-028721-x6f26ahr 103 17 pass pass VBP cord-028721-x6f26ahr 103 18 caudally caudally RB cord-028721-x6f26ahr 103 19 , , , cord-028721-x6f26ahr 103 20 the the DT cord-028721-x6f26ahr 103 21 müllerian müllerian JJ cord-028721-x6f26ahr 103 22 duct duct NN cord-028721-x6f26ahr 103 23 crosses cross VBZ cord-028721-x6f26ahr 103 24 over over IN cord-028721-x6f26ahr 103 25 the the DT cord-028721-x6f26ahr 103 26 wolffi wolffi NN cord-028721-x6f26ahr 103 27 an an DT cord-028721-x6f26ahr 103 28 duct duct NN cord-028721-x6f26ahr 103 29 and and CC cord-028721-x6f26ahr 103 30 lies lie NNS cord-028721-x6f26ahr 103 31 medial medial JJ cord-028721-x6f26ahr 103 32 to to IN cord-028721-x6f26ahr 103 33 it -PRON- PRP cord-028721-x6f26ahr 103 34 . . . cord-028721-x6f26ahr 104 1 Finally finally RB cord-028721-x6f26ahr 104 2 , , , cord-028721-x6f26ahr 104 3 the the DT cord-028721-x6f26ahr 104 4 two two CD cord-028721-x6f26ahr 104 5 müllerian müllerian JJ cord-028721-x6f26ahr 104 6 ducts duct NNS cord-028721-x6f26ahr 104 7 fuse fuse VBP cord-028721-x6f26ahr 104 8 into into IN cord-028721-x6f26ahr 104 9 the the DT cord-028721-x6f26ahr 104 10 uterovaginal uterovaginal JJ cord-028721-x6f26ahr 104 11 duct duct NN cord-028721-x6f26ahr 104 12 . . . cord-028721-x6f26ahr 105 1 This this DT cord-028721-x6f26ahr 105 2 elongates elongate VBZ cord-028721-x6f26ahr 105 3 caudally caudally RB cord-028721-x6f26ahr 105 4 up up IN cord-028721-x6f26ahr 105 5 to to IN cord-028721-x6f26ahr 105 6 the the DT cord-028721-x6f26ahr 105 7 posterior posterior JJ cord-028721-x6f26ahr 105 8 and and CC cord-028721-x6f26ahr 105 9 ovoid ovoid JJ cord-028721-x6f26ahr 105 10 euchromatic euchromatic JJ cord-028721-x6f26ahr 105 11 nucleus nucleus NN cord-028721-x6f26ahr 105 12 . . . cord-028721-x6f26ahr 106 1 The the DT cord-028721-x6f26ahr 106 2 cells cell NNS cord-028721-x6f26ahr 106 3 of of IN cord-028721-x6f26ahr 106 4 mesonephric mesonephric JJ cord-028721-x6f26ahr 106 5 origin origin NN cord-028721-x6f26ahr 106 6 are be VBP cord-028721-x6f26ahr 106 7 darker dark JJR cord-028721-x6f26ahr 106 8 and and CC cord-028721-x6f26ahr 106 9 have have VB cord-028721-x6f26ahr 106 10 a a DT cord-028721-x6f26ahr 106 11 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 106 12 pattern pattern NN cord-028721-x6f26ahr 106 13 . . . cord-028721-x6f26ahr 107 1 Initially initially RB cord-028721-x6f26ahr 107 2 , , , cord-028721-x6f26ahr 107 3 the the DT cord-028721-x6f26ahr 107 4 genital genital JJ cord-028721-x6f26ahr 107 5 ridges ridge NNS cord-028721-x6f26ahr 107 6 are be VBP cord-028721-x6f26ahr 107 7 devoid devoid JJ cord-028721-x6f26ahr 107 8 of of IN cord-028721-x6f26ahr 107 9 germ germ NN cord-028721-x6f26ahr 107 10 cells cell NNS cord-028721-x6f26ahr 107 11 . . . cord-028721-x6f26ahr 108 1 In in IN cord-028721-x6f26ahr 108 2 the the DT cord-028721-x6f26ahr 108 3 third third JJ cord-028721-x6f26ahr 108 4 week week NN cord-028721-x6f26ahr 108 5 , , , cord-028721-x6f26ahr 108 6 primordial primordial JJ cord-028721-x6f26ahr 108 7 germ germ NN cord-028721-x6f26ahr 108 8 cells cell NNS cord-028721-x6f26ahr 108 9 appear appear VBP cord-028721-x6f26ahr 108 10 in in IN cord-028721-x6f26ahr 108 11 the the DT cord-028721-x6f26ahr 108 12 extraembryonal extraembryonal JJ cord-028721-x6f26ahr 108 13 mesoderm mesoderm NNP cord-028721-x6f26ahr 108 14 lining line VBG cord-028721-x6f26ahr 108 15 the the DT cord-028721-x6f26ahr 108 16 posterior posterior JJ cord-028721-x6f26ahr 108 17 wall wall NN cord-028721-x6f26ahr 108 18 of of IN cord-028721-x6f26ahr 108 19 the the DT cord-028721-x6f26ahr 108 20 yolk yolk NN cord-028721-x6f26ahr 108 21 sac sac NN cord-028721-x6f26ahr 108 22 near near IN cord-028721-x6f26ahr 108 23 the the DT cord-028721-x6f26ahr 108 24 allantoic allantoic NNP cord-028721-x6f26ahr 108 25 evagination evagination NNP cord-028721-x6f26ahr 108 26 . . . cord-028721-x6f26ahr 109 1 They -PRON- PRP cord-028721-x6f26ahr 109 2 are be VBP cord-028721-x6f26ahr 109 3 ovoid ovoid JJ cord-028721-x6f26ahr 109 4 , , , cord-028721-x6f26ahr 109 5 measuring measure VBG cord-028721-x6f26ahr 109 6 12 12 CD cord-028721-x6f26ahr 109 7 - - SYM cord-028721-x6f26ahr 109 8 14 14 CD cord-028721-x6f26ahr 109 9 µm µm NN cord-028721-x6f26ahr 109 10 in in IN cord-028721-x6f26ahr 109 11 diameter diameter NN cord-028721-x6f26ahr 109 12 , , , cord-028721-x6f26ahr 109 13 and and CC cord-028721-x6f26ahr 109 14 are be VBP cord-028721-x6f26ahr 109 15 easily easily RB cord-028721-x6f26ahr 109 16 detected detect VBN cord-028721-x6f26ahr 109 17 histochemically histochemically RB cord-028721-x6f26ahr 109 18 by by IN cord-028721-x6f26ahr 109 19 a a DT cord-028721-x6f26ahr 109 20 high high JJ cord-028721-x6f26ahr 109 21 content content NN cord-028721-x6f26ahr 109 22 of of IN cord-028721-x6f26ahr 109 23 alkaline alkaline JJ cord-028721-x6f26ahr 109 24 phosphatase phosphatase NN cord-028721-x6f26ahr 109 25 . . . cord-028721-x6f26ahr 110 1 The the DT cord-028721-x6f26ahr 110 2 nuclei nucleus NNS cord-028721-x6f26ahr 110 3 are be VBP cord-028721-x6f26ahr 110 4 spherical spherical JJ cord-028721-x6f26ahr 110 5 and and CC cord-028721-x6f26ahr 110 6 possess possess VBP cord-028721-x6f26ahr 110 7 one one CD cord-028721-x6f26ahr 110 8 or or CC cord-028721-x6f26ahr 110 9 two two CD cord-028721-x6f26ahr 110 10 prominent prominent JJ cord-028721-x6f26ahr 110 11 central central JJ cord-028721-x6f26ahr 110 12 nucleoli nucleolus NNS cord-028721-x6f26ahr 110 13 . . . cord-028721-x6f26ahr 111 1 The the DT cord-028721-x6f26ahr 111 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 111 3 contains contain VBZ cord-028721-x6f26ahr 111 4 mitochondria mitochondrion NNS cord-028721-x6f26ahr 111 5 with with IN cord-028721-x6f26ahr 111 6 tubular tubular JJ cord-028721-x6f26ahr 111 7 cristae cristae NN cord-028721-x6f26ahr 111 8 , , , cord-028721-x6f26ahr 111 9 lysosomes lysosome NNS cord-028721-x6f26ahr 111 10 , , , cord-028721-x6f26ahr 111 11 microfi microfi NNP cord-028721-x6f26ahr 111 12 laments lament NNS cord-028721-x6f26ahr 111 13 , , , cord-028721-x6f26ahr 111 14 lipid lipid NN cord-028721-x6f26ahr 111 15 inclusions inclusion NNS cord-028721-x6f26ahr 111 16 , , , cord-028721-x6f26ahr 111 17 numerous numerous JJ cord-028721-x6f26ahr 111 18 ribosomes ribosome NNS cord-028721-x6f26ahr 111 19 , , , cord-028721-x6f26ahr 111 20 and and CC cord-028721-x6f26ahr 111 21 abundant abundant JJ cord-028721-x6f26ahr 111 22 glycogen glycogen NN cord-028721-x6f26ahr 111 23 granules granule NNS cord-028721-x6f26ahr 111 24 . . . cord-028721-x6f26ahr 112 1 Attracted attract VBN cord-028721-x6f26ahr 112 2 by by IN cord-028721-x6f26ahr 112 3 chemotactic chemotactic JJ cord-028721-x6f26ahr 112 4 factors factor NNS cord-028721-x6f26ahr 112 5 , , , cord-028721-x6f26ahr 112 6 the the DT cord-028721-x6f26ahr 112 7 primordial primordial JJ cord-028721-x6f26ahr 112 8 germ germ NN cord-028721-x6f26ahr 112 9 cells cell NNS cord-028721-x6f26ahr 112 10 migrate migrate VBP cord-028721-x6f26ahr 112 11 along along IN cord-028721-x6f26ahr 112 12 the the DT cord-028721-x6f26ahr 112 13 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 112 14 of of IN cord-028721-x6f26ahr 112 15 the the DT cord-028721-x6f26ahr 112 16 mesentery mesentery NN cord-028721-x6f26ahr 112 17 and and CC cord-028721-x6f26ahr 112 18 reach reach VB cord-028721-x6f26ahr 112 19 the the DT cord-028721-x6f26ahr 112 20 genital genital JJ cord-028721-x6f26ahr 112 21 ridge ridge NN cord-028721-x6f26ahr 112 22 by by IN cord-028721-x6f26ahr 112 23 32 32 CD cord-028721-x6f26ahr 112 24 - - SYM cord-028721-x6f26ahr 112 25 35 35 CD cord-028721-x6f26ahr 112 26 days day NNS cord-028721-x6f26ahr 112 27 . . . cord-028721-x6f26ahr 113 1 The the DT cord-028721-x6f26ahr 113 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 113 3 cords cord NNS cord-028721-x6f26ahr 113 4 arise arise VBP cord-028721-x6f26ahr 113 5 from from IN cord-028721-x6f26ahr 113 6 the the DT cord-028721-x6f26ahr 113 7 gonadal gonadal JJ cord-028721-x6f26ahr 113 8 blastema blastema NNP cord-028721-x6f26ahr 113 9 . . . cord-028721-x6f26ahr 114 1 31,32 31,32 CD cord-028721-x6f26ahr 114 2 Many many JJ cord-028721-x6f26ahr 114 3 germ germ NN cord-028721-x6f26ahr 114 4 cells cell NNS cord-028721-x6f26ahr 114 5 reach reach VBP cord-028721-x6f26ahr 114 6 the the DT cord-028721-x6f26ahr 114 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 114 8 cords cord NNS cord-028721-x6f26ahr 114 9 , , , cord-028721-x6f26ahr 114 10 but but CC cord-028721-x6f26ahr 114 11 some some DT cord-028721-x6f26ahr 114 12 degenerate degenerate VBP cord-028721-x6f26ahr 114 13 during during IN cord-028721-x6f26ahr 114 14 migration migration NN cord-028721-x6f26ahr 114 15 . . . cord-028721-x6f26ahr 115 1 The the DT cord-028721-x6f26ahr 115 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 115 3 cords cord NNS cord-028721-x6f26ahr 115 4 are be VBP cord-028721-x6f26ahr 115 5 delimited delimit VBN cord-028721-x6f26ahr 115 6 from from IN cord-028721-x6f26ahr 115 7 the the DT cord-028721-x6f26ahr 115 8 stroma stroma NN cord-028721-x6f26ahr 115 9 by by IN cord-028721-x6f26ahr 115 10 a a DT cord-028721-x6f26ahr 115 11 basement basement NN cord-028721-x6f26ahr 115 12 membrane membrane NN cord-028721-x6f26ahr 115 13 33 33 CD cord-028721-x6f26ahr 115 14 and and CC cord-028721-x6f26ahr 115 15 lose lose VB cord-028721-x6f26ahr 115 16 their -PRON- PRP$ cord-028721-x6f26ahr 115 17 connection connection NN cord-028721-x6f26ahr 115 18 to to IN cord-028721-x6f26ahr 115 19 the the DT cord-028721-x6f26ahr 115 20 celomic celomic JJ cord-028721-x6f26ahr 115 21 epithelium epithelium NN cord-028721-x6f26ahr 115 22 , , , cord-028721-x6f26ahr 115 23 which which WDT cord-028721-x6f26ahr 115 24 reduces reduce VBZ cord-028721-x6f26ahr 115 25 its -PRON- PRP$ cord-028721-x6f26ahr 115 26 depth depth NN cord-028721-x6f26ahr 115 27 to to IN cord-028721-x6f26ahr 115 28 one one CD cord-028721-x6f26ahr 115 29 or or CC cord-028721-x6f26ahr 115 30 two two CD cord-028721-x6f26ahr 115 31 cell cell NN cord-028721-x6f26ahr 115 32 layers layer NNS cord-028721-x6f26ahr 115 33 only only RB cord-028721-x6f26ahr 115 34 . . . cord-028721-x6f26ahr 116 1 The the DT cord-028721-x6f26ahr 116 2 intercordal intercordal NNP cord-028721-x6f26ahr 116 3 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 116 4 , , , cord-028721-x6f26ahr 116 5 composed compose VBD cord-028721-x6f26ahr 116 6 chiefl chiefl NNP cord-028721-x6f26ahr 116 7 y y NNP cord-028721-x6f26ahr 116 8 of of IN cord-028721-x6f26ahr 116 9 cells cell NNS cord-028721-x6f26ahr 116 10 that that WDT cord-028721-x6f26ahr 116 11 migrated migrate VBD cord-028721-x6f26ahr 116 12 from from IN cord-028721-x6f26ahr 116 13 the the DT cord-028721-x6f26ahr 116 14 mesonephric mesonephric JJ cord-028721-x6f26ahr 116 15 stroma stroma NN cord-028721-x6f26ahr 116 16 , , , cord-028721-x6f26ahr 116 17 differentiate differentiate VB cord-028721-x6f26ahr 116 18 later later RB cord-028721-x6f26ahr 116 19 into into IN cord-028721-x6f26ahr 116 20 myoid myoid JJ cord-028721-x6f26ahr 116 21 cells cell NNS cord-028721-x6f26ahr 116 22 , , , cord-028721-x6f26ahr 116 23 Leydig leydig NN cord-028721-x6f26ahr 116 24 cells cell NNS cord-028721-x6f26ahr 116 25 , , , cord-028721-x6f26ahr 116 26 fi fi NNP cord-028721-x6f26ahr 116 27 broblasts broblasts NNP cord-028721-x6f26ahr 116 28 , , , cord-028721-x6f26ahr 116 29 and and CC cord-028721-x6f26ahr 116 30 blood blood NN cord-028721-x6f26ahr 116 31 vessels vessel NNS cord-028721-x6f26ahr 116 32 . . . cord-028721-x6f26ahr 117 1 34 34 CD cord-028721-x6f26ahr 118 1 Up up IN cord-028721-x6f26ahr 118 2 to to IN cord-028721-x6f26ahr 118 3 the the DT cord-028721-x6f26ahr 118 4 sixth sixth JJ cord-028721-x6f26ahr 118 5 week week NN cord-028721-x6f26ahr 118 6 , , , cord-028721-x6f26ahr 118 7 the the DT cord-028721-x6f26ahr 118 8 gonads gonad NNS cord-028721-x6f26ahr 118 9 appear appear VBP cord-028721-x6f26ahr 118 10 similar similar JJ cord-028721-x6f26ahr 118 11 , , , cord-028721-x6f26ahr 118 12 although although IN cord-028721-x6f26ahr 118 13 the the DT cord-028721-x6f26ahr 118 14 incipient incipient JJ cord-028721-x6f26ahr 118 15 testes testis NNS cord-028721-x6f26ahr 118 16 have have VBP cord-028721-x6f26ahr 118 17 more more JJR cord-028721-x6f26ahr 118 18 numerous numerous JJ cord-028721-x6f26ahr 118 19 blood blood NN cord-028721-x6f26ahr 118 20 vessels vessel NNS cord-028721-x6f26ahr 118 21 , , , cord-028721-x6f26ahr 118 22 more more RBR cord-028721-x6f26ahr 118 23 abundant abundant JJ cord-028721-x6f26ahr 118 24 stroma stroma NN cord-028721-x6f26ahr 118 25 , , , cord-028721-x6f26ahr 118 26 35 35 CD cord-028721-x6f26ahr 118 27 and and CC cord-028721-x6f26ahr 118 28 a a DT cord-028721-x6f26ahr 118 29 higher high JJR cord-028721-x6f26ahr 118 30 total total JJ cord-028721-x6f26ahr 118 31 DNA dna NN cord-028721-x6f26ahr 118 32 content content NN cord-028721-x6f26ahr 118 33 , , , cord-028721-x6f26ahr 118 34 suggesting suggest VBG cord-028721-x6f26ahr 118 35 more more RBR cord-028721-x6f26ahr 118 36 rapid rapid JJ cord-028721-x6f26ahr 118 37 growth growth NN cord-028721-x6f26ahr 118 38 . . . cord-028721-x6f26ahr 119 1 Sertoli sertoli JJ cord-028721-x6f26ahr 119 2 cells cell NNS cord-028721-x6f26ahr 119 3 arise arise VBP cord-028721-x6f26ahr 119 4 from from IN cord-028721-x6f26ahr 119 5 somatic somatic JJ cord-028721-x6f26ahr 119 6 sex sex NN cord-028721-x6f26ahr 119 7 cord cord NN cord-028721-x6f26ahr 119 8 cells cell NNS cord-028721-x6f26ahr 119 9 . . . cord-028721-x6f26ahr 120 1 These these DT cord-028721-x6f26ahr 120 2 cells cell NNS cord-028721-x6f26ahr 120 3 differentiate differentiate VBP cord-028721-x6f26ahr 120 4 at at IN cord-028721-x6f26ahr 120 5 the the DT cord-028721-x6f26ahr 120 6 end end NN cord-028721-x6f26ahr 120 7 of of IN cord-028721-x6f26ahr 120 8 the the DT cord-028721-x6f26ahr 120 9 seventh seventh JJ cord-028721-x6f26ahr 120 10 week week NN cord-028721-x6f26ahr 120 11 from from IN cord-028721-x6f26ahr 120 12 the the DT cord-028721-x6f26ahr 120 13 somatic somatic JJ cord-028721-x6f26ahr 120 14 cells cell NNS cord-028721-x6f26ahr 120 15 in in IN cord-028721-x6f26ahr 120 16 the the DT cord-028721-x6f26ahr 120 17 cords cord NNS cord-028721-x6f26ahr 120 18 , , , cord-028721-x6f26ahr 120 19 develop develop VB cord-028721-x6f26ahr 120 20 adherent adherent JJ cord-028721-x6f26ahr 120 21 junctions junction NNS cord-028721-x6f26ahr 120 22 between between IN cord-028721-x6f26ahr 120 23 them -PRON- PRP cord-028721-x6f26ahr 120 24 and and CC cord-028721-x6f26ahr 120 25 a a DT cord-028721-x6f26ahr 120 26 basal basal NN cord-028721-x6f26ahr 120 27 lamina lamina NN cord-028721-x6f26ahr 120 28 on on IN cord-028721-x6f26ahr 120 29 the the DT cord-028721-x6f26ahr 120 30 other other JJ cord-028721-x6f26ahr 120 31 cord cord NN cord-028721-x6f26ahr 120 32 surface surface NN cord-028721-x6f26ahr 120 33 , , , cord-028721-x6f26ahr 120 34 and and CC cord-028721-x6f26ahr 120 35 begin begin VB cord-028721-x6f26ahr 120 36 to to TO cord-028721-x6f26ahr 120 37 express express VB cord-028721-x6f26ahr 120 38 AMH AMH NNP cord-028721-x6f26ahr 120 39 . . . cord-028721-x6f26ahr 121 1 36 36 CD cord-028721-x6f26ahr 122 1 In in IN cord-028721-x6f26ahr 122 2 the the DT cord-028721-x6f26ahr 122 3 eighth eighth JJ cord-028721-x6f26ahr 122 4 week week NN cord-028721-x6f26ahr 122 5 , , , cord-028721-x6f26ahr 122 6 Leydig leydig NN cord-028721-x6f26ahr 122 7 cells cell NNS cord-028721-x6f26ahr 122 8 differentiate differentiate VBP cord-028721-x6f26ahr 122 9 from from IN cord-028721-x6f26ahr 122 10 the the DT cord-028721-x6f26ahr 122 11 intercordal intercordal NNP cord-028721-x6f26ahr 122 12 gonadal gonadal NNP cord-028721-x6f26ahr 122 13 blastema blastema NNP cord-028721-x6f26ahr 122 14 , , , cord-028721-x6f26ahr 122 15 37 37 CD cord-028721-x6f26ahr 122 16 and and CC cord-028721-x6f26ahr 122 17 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 122 18 detection detection NN cord-028721-x6f26ahr 122 19 of of IN cord-028721-x6f26ahr 122 20 3β 3β CD cord-028721-x6f26ahr 122 21 - - : cord-028721-x6f26ahr 122 22 HSD HSD NNP cord-028721-x6f26ahr 122 23 is be VBZ cord-028721-x6f26ahr 122 24 apparently apparently RB cord-028721-x6f26ahr 122 25 the the DT cord-028721-x6f26ahr 122 26 fi fi NN cord-028721-x6f26ahr 122 27 rst rst NN cord-028721-x6f26ahr 122 28 step step NN cord-028721-x6f26ahr 122 29 in in IN cord-028721-x6f26ahr 122 30 this this DT cord-028721-x6f26ahr 122 31 process process NN cord-028721-x6f26ahr 122 32 . . . cord-028721-x6f26ahr 123 1 Leydig leydig NN cord-028721-x6f26ahr 123 2 cell cell NN cord-028721-x6f26ahr 123 3 development development NN cord-028721-x6f26ahr 123 4 peaks peak NNS cord-028721-x6f26ahr 123 5 during during IN cord-028721-x6f26ahr 123 6 the the DT cord-028721-x6f26ahr 123 7 18th 18th JJ cord-028721-x6f26ahr 123 8 week week NN cord-028721-x6f26ahr 123 9 , , , cord-028721-x6f26ahr 123 10 and and CC cord-028721-x6f26ahr 123 11 numbers number NNS cord-028721-x6f26ahr 123 12 subsequently subsequently RB cord-028721-x6f26ahr 123 13 decrease decrease VBP cord-028721-x6f26ahr 123 14 progressively progressively RB cord-028721-x6f26ahr 123 15 . . . cord-028721-x6f26ahr 124 1 38 38 CD cord-028721-x6f26ahr 124 2 aspect aspect NN cord-028721-x6f26ahr 124 3 of of IN cord-028721-x6f26ahr 124 4 the the DT cord-028721-x6f26ahr 124 5 urogenital urogenital JJ cord-028721-x6f26ahr 124 6 sinus sinus NN cord-028721-x6f26ahr 124 7 , , , cord-028721-x6f26ahr 124 8 forming form VBG cord-028721-x6f26ahr 124 9 the the DT cord-028721-x6f26ahr 124 10 müllerian müllerian JJ cord-028721-x6f26ahr 124 11 tubercle tubercle NN cord-028721-x6f26ahr 124 12 . . . cord-028721-x6f26ahr 125 1 The the DT cord-028721-x6f26ahr 125 2 wolffi wolffi NN cord-028721-x6f26ahr 125 3 an an DT cord-028721-x6f26ahr 125 4 ducts duct NNS cord-028721-x6f26ahr 125 5 terminate terminate VBP cord-028721-x6f26ahr 125 6 at at IN cord-028721-x6f26ahr 125 7 either either DT cord-028721-x6f26ahr 125 8 side side NN cord-028721-x6f26ahr 125 9 of of IN cord-028721-x6f26ahr 125 10 this this DT cord-028721-x6f26ahr 125 11 tubercle tubercle NN cord-028721-x6f26ahr 125 12 . . . cord-028721-x6f26ahr 126 1 The the DT cord-028721-x6f26ahr 126 2 remaining remain VBG cord-028721-x6f26ahr 126 3 structures structure NNS cord-028721-x6f26ahr 126 4 of of IN cord-028721-x6f26ahr 126 5 the the DT cord-028721-x6f26ahr 126 6 male male JJ cord-028721-x6f26ahr 126 7 genital genital JJ cord-028721-x6f26ahr 126 8 system system NN cord-028721-x6f26ahr 126 9 are be VBP cord-028721-x6f26ahr 126 10 derived derive VBN cord-028721-x6f26ahr 126 11 from from IN cord-028721-x6f26ahr 126 12 the the DT cord-028721-x6f26ahr 126 13 urogenital urogenital JJ cord-028721-x6f26ahr 126 14 sinus sinus NN cord-028721-x6f26ahr 126 15 . . . cord-028721-x6f26ahr 127 1 Epithelium epithelium NN cord-028721-x6f26ahr 127 2 with with IN cord-028721-x6f26ahr 127 3 endodermal endodermal NNP cord-028721-x6f26ahr 127 4 origin origin NNP cord-028721-x6f26ahr 127 5 forms form VBZ cord-028721-x6f26ahr 127 6 the the DT cord-028721-x6f26ahr 127 7 prostate prostate NN cord-028721-x6f26ahr 127 8 , , , cord-028721-x6f26ahr 127 9 the the DT cord-028721-x6f26ahr 127 10 urethra urethra NN cord-028721-x6f26ahr 127 11 , , , cord-028721-x6f26ahr 127 12 and and CC cord-028721-x6f26ahr 127 13 the the DT cord-028721-x6f26ahr 127 14 bulbourethral bulbourethral JJ cord-028721-x6f26ahr 127 15 and and CC cord-028721-x6f26ahr 127 16 periurethral periurethral JJ cord-028721-x6f26ahr 127 17 glands gland NNS cord-028721-x6f26ahr 127 18 . . . cord-028721-x6f26ahr 128 1 The the DT cord-028721-x6f26ahr 128 2 primitive primitive JJ cord-028721-x6f26ahr 128 3 urogenital urogenital JJ cord-028721-x6f26ahr 128 4 sinus sinus NN cord-028721-x6f26ahr 128 5 derives derive VBZ cord-028721-x6f26ahr 128 6 from from IN cord-028721-x6f26ahr 128 7 the the DT cord-028721-x6f26ahr 128 8 cloaca cloaca NN cord-028721-x6f26ahr 128 9 , , , cord-028721-x6f26ahr 128 10 a a DT cord-028721-x6f26ahr 128 11 structure structure NN cord-028721-x6f26ahr 128 12 that that WDT cord-028721-x6f26ahr 128 13 appears appear VBZ cord-028721-x6f26ahr 128 14 at at IN cord-028721-x6f26ahr 128 15 the the DT cord-028721-x6f26ahr 128 16 end end NN cord-028721-x6f26ahr 128 17 of of IN cord-028721-x6f26ahr 128 18 the the DT cord-028721-x6f26ahr 128 19 fi fi NN cord-028721-x6f26ahr 128 20 rst rst NNP cord-028721-x6f26ahr 128 21 month month NN cord-028721-x6f26ahr 128 22 and and CC cord-028721-x6f26ahr 128 23 which which WDT cord-028721-x6f26ahr 128 24 consists consist VBZ cord-028721-x6f26ahr 128 25 of of IN cord-028721-x6f26ahr 128 26 a a DT cord-028721-x6f26ahr 128 27 dilation dilation NN cord-028721-x6f26ahr 128 28 of of IN cord-028721-x6f26ahr 128 29 the the DT cord-028721-x6f26ahr 128 30 terminal terminal JJ cord-028721-x6f26ahr 128 31 portion portion NN cord-028721-x6f26ahr 128 32 of of IN cord-028721-x6f26ahr 128 33 the the DT cord-028721-x6f26ahr 128 34 primitive primitive JJ cord-028721-x6f26ahr 128 35 posterior posterior JJ cord-028721-x6f26ahr 128 36 intestine intestine NN cord-028721-x6f26ahr 128 37 . . . cord-028721-x6f26ahr 129 1 The the DT cord-028721-x6f26ahr 129 2 cloaca cloaca NN cord-028721-x6f26ahr 129 3 is be VBZ cord-028721-x6f26ahr 129 4 closed close VBN cord-028721-x6f26ahr 129 5 by by IN cord-028721-x6f26ahr 129 6 the the DT cord-028721-x6f26ahr 129 7 cloacal cloacal JJ cord-028721-x6f26ahr 129 8 membrane membrane NN cord-028721-x6f26ahr 129 9 . . . cord-028721-x6f26ahr 130 1 In in IN cord-028721-x6f26ahr 130 2 the the DT cord-028721-x6f26ahr 130 3 third third JJ cord-028721-x6f26ahr 130 4 week week NN cord-028721-x6f26ahr 130 5 , , , cord-028721-x6f26ahr 130 6 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 130 7 proliferates proliferate VBZ cord-028721-x6f26ahr 130 8 in in IN cord-028721-x6f26ahr 130 9 the the DT cord-028721-x6f26ahr 130 10 outer outer JJ cord-028721-x6f26ahr 130 11 aspect aspect NN cord-028721-x6f26ahr 130 12 of of IN cord-028721-x6f26ahr 130 13 the the DT cord-028721-x6f26ahr 130 14 cloacal cloacal JJ cord-028721-x6f26ahr 130 15 membrane membrane NN cord-028721-x6f26ahr 130 16 to to TO cord-028721-x6f26ahr 130 17 form form VB cord-028721-x6f26ahr 130 18 the the DT cord-028721-x6f26ahr 130 19 cloacal cloacal JJ cord-028721-x6f26ahr 130 20 folds fold NNS cord-028721-x6f26ahr 130 21 and and CC cord-028721-x6f26ahr 130 22 the the DT cord-028721-x6f26ahr 130 23 cloacal cloacal JJ cord-028721-x6f26ahr 130 24 eminence eminence NN cord-028721-x6f26ahr 130 25 . . . cord-028721-x6f26ahr 131 1 In in IN cord-028721-x6f26ahr 131 2 the the DT cord-028721-x6f26ahr 131 3 sixth sixth JJ cord-028721-x6f26ahr 131 4 week week NN cord-028721-x6f26ahr 131 5 , , , cord-028721-x6f26ahr 131 6 the the DT cord-028721-x6f26ahr 131 7 cloacal cloacal JJ cord-028721-x6f26ahr 131 8 folds fold NNS cord-028721-x6f26ahr 131 9 enlarge enlarge VBP cord-028721-x6f26ahr 131 10 to to TO cord-028721-x6f26ahr 131 11 form form VB cord-028721-x6f26ahr 131 12 the the DT cord-028721-x6f26ahr 131 13 genital genital NN cord-028721-x6f26ahr 131 14 ( ( -LRB- cord-028721-x6f26ahr 131 15 or or CC cord-028721-x6f26ahr 131 16 urethral urethral JJ cord-028721-x6f26ahr 131 17 ) ) -RRB- cord-028721-x6f26ahr 131 18 tubercle tubercle NN cord-028721-x6f26ahr 131 19 . . . cord-028721-x6f26ahr 132 1 External external JJ cord-028721-x6f26ahr 132 2 to to IN cord-028721-x6f26ahr 132 3 the the DT cord-028721-x6f26ahr 132 4 genital genital JJ cord-028721-x6f26ahr 132 5 folds fold NNS cord-028721-x6f26ahr 132 6 , , , cord-028721-x6f26ahr 132 7 another another DT cord-028721-x6f26ahr 132 8 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 132 9 thickening thickening NN cord-028721-x6f26ahr 132 10 develops develop VBZ cord-028721-x6f26ahr 132 11 into into IN cord-028721-x6f26ahr 132 12 the the DT cord-028721-x6f26ahr 132 13 genital genital JJ cord-028721-x6f26ahr 132 14 prominences prominence NNS cord-028721-x6f26ahr 132 15 or or CC cord-028721-x6f26ahr 132 16 genital genital JJ cord-028721-x6f26ahr 132 17 swellings swelling NNS cord-028721-x6f26ahr 132 18 . . . cord-028721-x6f26ahr 133 1 In in IN cord-028721-x6f26ahr 133 2 the the DT cord-028721-x6f26ahr 133 3 fi fi NNP cord-028721-x6f26ahr 133 4 fth fth NNP cord-028721-x6f26ahr 133 5 week week NN cord-028721-x6f26ahr 133 6 , , , cord-028721-x6f26ahr 133 7 a a DT cord-028721-x6f26ahr 133 8 septum septum NN cord-028721-x6f26ahr 133 9 forms form NNS cord-028721-x6f26ahr 133 10 , , , cord-028721-x6f26ahr 133 11 dividing divide VBG cord-028721-x6f26ahr 133 12 the the DT cord-028721-x6f26ahr 133 13 cloaca cloaca NN cord-028721-x6f26ahr 133 14 into into IN cord-028721-x6f26ahr 133 15 two two CD cord-028721-x6f26ahr 133 16 compartments compartment NNS cord-028721-x6f26ahr 133 17 . . . cord-028721-x6f26ahr 134 1 The the DT cord-028721-x6f26ahr 134 2 anterior anterior JJ cord-028721-x6f26ahr 134 3 compartment compartment NN cord-028721-x6f26ahr 134 4 is be VBZ cord-028721-x6f26ahr 134 5 the the DT cord-028721-x6f26ahr 134 6 primitive primitive JJ cord-028721-x6f26ahr 134 7 urogenital urogenital JJ cord-028721-x6f26ahr 134 8 sinus sinus NN cord-028721-x6f26ahr 134 9 that that WDT cord-028721-x6f26ahr 134 10 is be VBZ cord-028721-x6f26ahr 134 11 covered cover VBN cord-028721-x6f26ahr 134 12 by by IN cord-028721-x6f26ahr 134 13 the the DT cord-028721-x6f26ahr 134 14 urogenital urogenital JJ cord-028721-x6f26ahr 134 15 membrane membrane NN cord-028721-x6f26ahr 134 16 . . . cord-028721-x6f26ahr 135 1 The the DT cord-028721-x6f26ahr 135 2 posterior posterior JJ cord-028721-x6f26ahr 135 3 compartment compartment NN cord-028721-x6f26ahr 135 4 is be VBZ cord-028721-x6f26ahr 135 5 the the DT cord-028721-x6f26ahr 135 6 anorectal anorectal JJ cord-028721-x6f26ahr 135 7 canal canal NN cord-028721-x6f26ahr 135 8 , , , cord-028721-x6f26ahr 135 9 covered cover VBN cord-028721-x6f26ahr 135 10 by by IN cord-028721-x6f26ahr 135 11 the the DT cord-028721-x6f26ahr 135 12 anal anal JJ cord-028721-x6f26ahr 135 13 membrane membrane NN cord-028721-x6f26ahr 135 14 . . . cord-028721-x6f26ahr 136 1 The the DT cord-028721-x6f26ahr 136 2 primitive primitive JJ cord-028721-x6f26ahr 136 3 urogenital urogenital JJ cord-028721-x6f26ahr 136 4 sinus sinus NN cord-028721-x6f26ahr 136 5 then then RB cord-028721-x6f26ahr 136 6 divides divide VBZ cord-028721-x6f26ahr 136 7 into into IN cord-028721-x6f26ahr 136 8 two two CD cord-028721-x6f26ahr 136 9 new new JJ cord-028721-x6f26ahr 136 10 compartments compartment NNS cord-028721-x6f26ahr 136 11 : : : cord-028721-x6f26ahr 136 12 superior superior JJ cord-028721-x6f26ahr 136 13 and and CC cord-028721-x6f26ahr 136 14 inferior inferior JJ cord-028721-x6f26ahr 136 15 . . . cord-028721-x6f26ahr 137 1 The the DT cord-028721-x6f26ahr 137 2 superior superior JJ cord-028721-x6f26ahr 137 3 compartment compartment NN cord-028721-x6f26ahr 137 4 is be VBZ cord-028721-x6f26ahr 137 5 the the DT cord-028721-x6f26ahr 137 6 vesicourethral vesicourethral NNP cord-028721-x6f26ahr 137 7 canal canal NN cord-028721-x6f26ahr 137 8 that that WDT cord-028721-x6f26ahr 137 9 later later RB cord-028721-x6f26ahr 137 10 forms form VBZ cord-028721-x6f26ahr 137 11 the the DT cord-028721-x6f26ahr 137 12 urinary urinary JJ cord-028721-x6f26ahr 137 13 bladder bladder NN cord-028721-x6f26ahr 137 14 and and CC cord-028721-x6f26ahr 137 15 the the DT cord-028721-x6f26ahr 137 16 urethra urethra NN cord-028721-x6f26ahr 137 17 . . . cord-028721-x6f26ahr 138 1 The the DT cord-028721-x6f26ahr 138 2 inferior inferior JJ cord-028721-x6f26ahr 138 3 compartment compartment NN cord-028721-x6f26ahr 138 4 is be VBZ cord-028721-x6f26ahr 138 5 the the DT cord-028721-x6f26ahr 138 6 defi defi NNP cord-028721-x6f26ahr 138 7 nitive nitive JJ cord-028721-x6f26ahr 138 8 urogenital urogenital JJ cord-028721-x6f26ahr 138 9 sinus sinus NN cord-028721-x6f26ahr 138 10 that that WDT cord-028721-x6f26ahr 138 11 will will MD cord-028721-x6f26ahr 138 12 develop develop VB cord-028721-x6f26ahr 138 13 later later RB cord-028721-x6f26ahr 138 14 according accord VBG cord-028721-x6f26ahr 138 15 to to IN cord-028721-x6f26ahr 138 16 the the DT cord-028721-x6f26ahr 138 17 gender gender NN cord-028721-x6f26ahr 138 18 . . . cord-028721-x6f26ahr 139 1 The the DT cord-028721-x6f26ahr 139 2 development development NN cord-028721-x6f26ahr 139 3 of of IN cord-028721-x6f26ahr 139 4 the the DT cord-028721-x6f26ahr 139 5 male male JJ cord-028721-x6f26ahr 139 6 genital genital NN cord-028721-x6f26ahr 139 7 system system NN cord-028721-x6f26ahr 139 8 is be VBZ cord-028721-x6f26ahr 139 9 directly directly RB cord-028721-x6f26ahr 139 10 infl infl NN cord-028721-x6f26ahr 139 11 uenced uence VBN cord-028721-x6f26ahr 139 12 by by IN cord-028721-x6f26ahr 139 13 the the DT cord-028721-x6f26ahr 139 14 action action NN cord-028721-x6f26ahr 139 15 of of IN cord-028721-x6f26ahr 139 16 multiple multiple JJ cord-028721-x6f26ahr 139 17 hormones hormone NNS cord-028721-x6f26ahr 139 18 , , , cord-028721-x6f26ahr 139 19 including include VBG cord-028721-x6f26ahr 139 20 anti anti JJ cord-028721-x6f26ahr 139 21 - - JJ cord-028721-x6f26ahr 139 22 müllerian müllerian JJ cord-028721-x6f26ahr 139 23 hormone hormone NN cord-028721-x6f26ahr 139 24 ( ( -LRB- cord-028721-x6f26ahr 139 25 AMH AMH NNP cord-028721-x6f26ahr 139 26 ) ) -RRB- cord-028721-x6f26ahr 139 27 , , , cord-028721-x6f26ahr 139 28 dihydrotestosterone dihydrotestosterone NN cord-028721-x6f26ahr 139 29 ( ( -LRB- cord-028721-x6f26ahr 139 30 derived derive VBN cord-028721-x6f26ahr 139 31 from from IN cord-028721-x6f26ahr 139 32 testosterone testosterone NN cord-028721-x6f26ahr 139 33 ) ) -RRB- cord-028721-x6f26ahr 139 34 , , , cord-028721-x6f26ahr 139 35 and and CC cord-028721-x6f26ahr 139 36 the the DT cord-028721-x6f26ahr 139 37 pituitary pituitary JJ cord-028721-x6f26ahr 139 38 hormones hormone NNS cord-028721-x6f26ahr 139 39 folliclestimulating folliclestimulate VBG cord-028721-x6f26ahr 139 40 hormone hormone NN cord-028721-x6f26ahr 139 41 ( ( -LRB- cord-028721-x6f26ahr 139 42 FSH FSH NNP cord-028721-x6f26ahr 139 43 ) ) -RRB- cord-028721-x6f26ahr 139 44 and and CC cord-028721-x6f26ahr 139 45 luteinizing luteinize VBG cord-028721-x6f26ahr 139 46 hormone hormone NN cord-028721-x6f26ahr 139 47 ( ( -LRB- cord-028721-x6f26ahr 139 48 LH LH NNP cord-028721-x6f26ahr 139 49 ) ) -RRB- cord-028721-x6f26ahr 139 50 . . . cord-028721-x6f26ahr 140 1 AMH amh NN cord-028721-x6f26ahr 140 2 ( ( -LRB- cord-028721-x6f26ahr 140 3 müllerian müllerian JJ cord-028721-x6f26ahr 140 4 inhibitory inhibitory JJ cord-028721-x6f26ahr 140 5 substance substance NN cord-028721-x6f26ahr 140 6 ; ; : cord-028721-x6f26ahr 140 7 MIS MIS NNP cord-028721-x6f26ahr 140 8 ) ) -RRB- cord-028721-x6f26ahr 140 9 , , , cord-028721-x6f26ahr 140 10 39 39 CD cord-028721-x6f26ahr 140 11 secreted secrete VBN cord-028721-x6f26ahr 140 12 by by IN cord-028721-x6f26ahr 140 13 the the DT cord-028721-x6f26ahr 140 14 Sertoli Sertoli NNP cord-028721-x6f26ahr 140 15 cells cell NNS cord-028721-x6f26ahr 140 16 , , , cord-028721-x6f26ahr 140 17 is be VBZ cord-028721-x6f26ahr 140 18 a a DT cord-028721-x6f26ahr 140 19 glycoprotein glycoprotein NN cord-028721-x6f26ahr 140 20 polymer polymer NN cord-028721-x6f26ahr 140 21 consisting consist VBG cord-028721-x6f26ahr 140 22 of of IN cord-028721-x6f26ahr 140 23 two two CD cord-028721-x6f26ahr 140 24 identical identical JJ cord-028721-x6f26ahr 140 25 72 72 CD cord-028721-x6f26ahr 140 26 kDa kDa NNS cord-028721-x6f26ahr 140 27 subunits subunit NNS cord-028721-x6f26ahr 140 28 linked link VBN cord-028721-x6f26ahr 140 29 by by IN cord-028721-x6f26ahr 140 30 disulfi disulfi NNP cord-028721-x6f26ahr 140 31 de de NNP cord-028721-x6f26ahr 140 32 bonds bond NNS cord-028721-x6f26ahr 140 33 . . . cord-028721-x6f26ahr 141 1 [ [ -LRB- cord-028721-x6f26ahr 141 2 40 40 CD cord-028721-x6f26ahr 141 3 ] ] -RRB- cord-028721-x6f26ahr 141 4 [ [ -LRB- cord-028721-x6f26ahr 141 5 41 41 CD cord-028721-x6f26ahr 141 6 ] ] -RRB- cord-028721-x6f26ahr 142 1 [ [ -LRB- cord-028721-x6f26ahr 142 2 42 42 CD cord-028721-x6f26ahr 142 3 ] ] -RRB- cord-028721-x6f26ahr 143 1 It -PRON- PRP cord-028721-x6f26ahr 143 2 belongs belong VBZ cord-028721-x6f26ahr 143 3 to to IN cord-028721-x6f26ahr 143 4 the the DT cord-028721-x6f26ahr 143 5 TGF TGF NNP cord-028721-x6f26ahr 143 6 - - HYPH cord-028721-x6f26ahr 143 7 β β NNP cord-028721-x6f26ahr 143 8 family family NN cord-028721-x6f26ahr 143 9 and and CC cord-028721-x6f26ahr 143 10 is be VBZ cord-028721-x6f26ahr 143 11 synthesized synthesize VBN cord-028721-x6f26ahr 143 12 as as IN cord-028721-x6f26ahr 143 13 a a DT cord-028721-x6f26ahr 143 14 560 560 CD cord-028721-x6f26ahr 143 15 amino amino NN cord-028721-x6f26ahr 143 16 - - HYPH cord-028721-x6f26ahr 143 17 acid acid NN cord-028721-x6f26ahr 143 18 precursor precursor NN cord-028721-x6f26ahr 143 19 protein protein NN cord-028721-x6f26ahr 143 20 with with IN cord-028721-x6f26ahr 143 21 proteolytic proteolytic JJ cord-028721-x6f26ahr 143 22 cleavage cleavage NN cord-028721-x6f26ahr 143 23 at at IN cord-028721-x6f26ahr 143 24 109 109 CD cord-028721-x6f26ahr 143 25 amino amino JJ cord-028721-x6f26ahr 143 26 acids acid NNS cord-028721-x6f26ahr 143 27 from from IN cord-028721-x6f26ahr 143 28 the the DT cord-028721-x6f26ahr 143 29 C C NNP cord-028721-x6f26ahr 143 30 terminal terminal NN cord-028721-x6f26ahr 143 31 . . . cord-028721-x6f26ahr 144 1 Cleavage cleavage NN cord-028721-x6f26ahr 144 2 is be VBZ cord-028721-x6f26ahr 144 3 necessary necessary JJ cord-028721-x6f26ahr 144 4 to to TO cord-028721-x6f26ahr 144 5 activate activate VB cord-028721-x6f26ahr 144 6 the the DT cord-028721-x6f26ahr 144 7 hormone hormone NN cord-028721-x6f26ahr 144 8 . . . cord-028721-x6f26ahr 145 1 AMH AMH NNP cord-028721-x6f26ahr 145 2 is be VBZ cord-028721-x6f26ahr 145 3 encoded encode VBN cord-028721-x6f26ahr 145 4 by by IN cord-028721-x6f26ahr 145 5 a a DT cord-028721-x6f26ahr 145 6 2.75 2.75 CD cord-028721-x6f26ahr 145 7 kb kb NNP cord-028721-x6f26ahr 145 8 gene gene NN cord-028721-x6f26ahr 145 9 that that WDT cord-028721-x6f26ahr 145 10 comprises comprise VBZ cord-028721-x6f26ahr 145 11 fi fi NNP cord-028721-x6f26ahr 145 12 ve ve NNP cord-028721-x6f26ahr 145 13 exons exon NNS cord-028721-x6f26ahr 145 14 and and CC cord-028721-x6f26ahr 145 15 is be VBZ cord-028721-x6f26ahr 145 16 located locate VBN cord-028721-x6f26ahr 145 17 on on IN cord-028721-x6f26ahr 145 18 the the DT cord-028721-x6f26ahr 145 19 p13.2 p13.2 NN cord-028721-x6f26ahr 145 20 region region NN cord-028721-x6f26ahr 145 21 of of IN cord-028721-x6f26ahr 145 22 chromosome chromosome NN cord-028721-x6f26ahr 145 23 19 19 CD cord-028721-x6f26ahr 145 24 . . . cord-028721-x6f26ahr 146 1 AMH AMH NNP cord-028721-x6f26ahr 146 2 is be VBZ cord-028721-x6f26ahr 146 3 secreted secrete VBN cord-028721-x6f26ahr 146 4 by by IN cord-028721-x6f26ahr 146 5 somatic somatic JJ cord-028721-x6f26ahr 146 6 cells cell NNS cord-028721-x6f26ahr 146 7 only only RB cord-028721-x6f26ahr 146 8 in in IN cord-028721-x6f26ahr 146 9 both both DT cord-028721-x6f26ahr 146 10 sexes sex NNS cord-028721-x6f26ahr 146 11 : : : cord-028721-x6f26ahr 146 12 Sertoli sertoli JJ cord-028721-x6f26ahr 146 13 cells cell NNS cord-028721-x6f26ahr 146 14 in in IN cord-028721-x6f26ahr 146 15 males male NNS cord-028721-x6f26ahr 146 16 and and CC cord-028721-x6f26ahr 146 17 granulosa granulosa JJ cord-028721-x6f26ahr 146 18 cells cell NNS cord-028721-x6f26ahr 146 19 in in IN cord-028721-x6f26ahr 146 20 females female NNS cord-028721-x6f26ahr 146 21 . . . cord-028721-x6f26ahr 147 1 It -PRON- PRP cord-028721-x6f26ahr 147 2 is be VBZ cord-028721-x6f26ahr 147 3 detected detect VBN cord-028721-x6f26ahr 147 4 by by IN cord-028721-x6f26ahr 147 5 6 6 CD cord-028721-x6f26ahr 147 6 - - SYM cord-028721-x6f26ahr 147 7 7 7 CD cord-028721-x6f26ahr 147 8 weeks week NNS cord-028721-x6f26ahr 147 9 of of IN cord-028721-x6f26ahr 147 10 gonadal gonadal JJ cord-028721-x6f26ahr 147 11 development development NN cord-028721-x6f26ahr 147 12 ( ( -LRB- cord-028721-x6f26ahr 147 13 8 8 CD cord-028721-x6f26ahr 147 14 - - SYM cord-028721-x6f26ahr 147 15 9 9 CD cord-028721-x6f26ahr 147 16 weeks week NNS cord-028721-x6f26ahr 147 17 of of IN cord-028721-x6f26ahr 147 18 gestation gestation NN cord-028721-x6f26ahr 147 19 ) ) -RRB- cord-028721-x6f26ahr 147 20 , , , cord-028721-x6f26ahr 147 21 probably probably RB cord-028721-x6f26ahr 147 22 as as RB cord-028721-x6f26ahr 147 23 soon soon RB cord-028721-x6f26ahr 147 24 as as IN cord-028721-x6f26ahr 147 25 germ germ NN cord-028721-x6f26ahr 147 26 cells cell NNS cord-028721-x6f26ahr 147 27 make make VBP cord-028721-x6f26ahr 147 28 contact contact NN cord-028721-x6f26ahr 147 29 with with IN cord-028721-x6f26ahr 147 30 pre pre JJ cord-028721-x6f26ahr 147 31 - - JJ cord-028721-x6f26ahr 147 32 Sertoli sertoli JJ cord-028721-x6f26ahr 147 33 cells cell NNS cord-028721-x6f26ahr 147 34 , , , cord-028721-x6f26ahr 147 35 a a DT cord-028721-x6f26ahr 147 36 week week NN cord-028721-x6f26ahr 147 37 before before IN cord-028721-x6f26ahr 147 38 the the DT cord-028721-x6f26ahr 147 39 müllerian müllerian JJ cord-028721-x6f26ahr 147 40 ducts duct NNS cord-028721-x6f26ahr 147 41 lose lose VBP cord-028721-x6f26ahr 147 42 their -PRON- PRP$ cord-028721-x6f26ahr 147 43 responsiveness responsiveness NN cord-028721-x6f26ahr 147 44 . . . cord-028721-x6f26ahr 148 1 43 43 CD cord-028721-x6f26ahr 148 2 , , , cord-028721-x6f26ahr 148 3 44 44 CD cord-028721-x6f26ahr 148 4 AMH amh NN cord-028721-x6f26ahr 148 5 is be VBZ cord-028721-x6f26ahr 148 6 at at IN cord-028721-x6f26ahr 148 7 high high JJ cord-028721-x6f26ahr 148 8 concentration concentration NN cord-028721-x6f26ahr 148 9 in in IN cord-028721-x6f26ahr 148 10 the the DT cord-028721-x6f26ahr 148 11 second second JJ cord-028721-x6f26ahr 148 12 trimester trimester NN cord-028721-x6f26ahr 148 13 , , , cord-028721-x6f26ahr 148 14 but but CC cord-028721-x6f26ahr 148 15 drops drop VBZ cord-028721-x6f26ahr 148 16 precipitously precipitously RB cord-028721-x6f26ahr 148 17 in in IN cord-028721-x6f26ahr 148 18 the the DT cord-028721-x6f26ahr 148 19 third third JJ cord-028721-x6f26ahr 148 20 trimester trimester NN cord-028721-x6f26ahr 148 21 . . . cord-028721-x6f26ahr 149 1 45 45 CD cord-028721-x6f26ahr 149 2 Levels level NNS cord-028721-x6f26ahr 149 3 rise rise VBP cord-028721-x6f26ahr 149 4 again again RB cord-028721-x6f26ahr 149 5 during during IN cord-028721-x6f26ahr 149 6 the the DT cord-028721-x6f26ahr 149 7 fi fi NNP cord-028721-x6f26ahr 149 8 rst rst NN cord-028721-x6f26ahr 149 9 year year NN cord-028721-x6f26ahr 149 10 after after IN cord-028721-x6f26ahr 149 11 birth birth NN cord-028721-x6f26ahr 149 12 , , , cord-028721-x6f26ahr 149 13 are be VBP cord-028721-x6f26ahr 149 14 detectable detectable JJ cord-028721-x6f26ahr 149 15 during during IN cord-028721-x6f26ahr 149 16 infancy infancy NN cord-028721-x6f26ahr 149 17 and and CC cord-028721-x6f26ahr 149 18 childhood childhood NN cord-028721-x6f26ahr 149 19 , , , cord-028721-x6f26ahr 149 20 and and CC cord-028721-x6f26ahr 149 21 fi fi NNP cord-028721-x6f26ahr 149 22 nally nally RB cord-028721-x6f26ahr 149 23 drop drop VB cord-028721-x6f26ahr 149 24 defi defi NNP cord-028721-x6f26ahr 149 25 nitively nitively NN cord-028721-x6f26ahr 149 26 to to IN cord-028721-x6f26ahr 149 27 undetectable undetectable JJ cord-028721-x6f26ahr 149 28 levels level NNS cord-028721-x6f26ahr 149 29 at at IN cord-028721-x6f26ahr 149 30 the the DT cord-028721-x6f26ahr 149 31 onset onset NN cord-028721-x6f26ahr 149 32 of of IN cord-028721-x6f26ahr 149 33 puberty puberty NN cord-028721-x6f26ahr 149 34 . . . cord-028721-x6f26ahr 150 1 The the DT cord-028721-x6f26ahr 150 2 secreted secrete VBN cord-028721-x6f26ahr 150 3 amount amount NN cord-028721-x6f26ahr 150 4 of of IN cord-028721-x6f26ahr 150 5 AMH amh NN cord-028721-x6f26ahr 150 6 is be VBZ cord-028721-x6f26ahr 150 7 inversely inversely RB cord-028721-x6f26ahr 150 8 correlated correlate VBN cord-028721-x6f26ahr 150 9 to to IN cord-028721-x6f26ahr 150 10 the the DT cord-028721-x6f26ahr 150 11 degree degree NN cord-028721-x6f26ahr 150 12 of of IN cord-028721-x6f26ahr 150 13 Sertoli sertoli JJ cord-028721-x6f26ahr 150 14 cell cell NN cord-028721-x6f26ahr 150 15 maturation maturation NN cord-028721-x6f26ahr 150 16 . . . cord-028721-x6f26ahr 151 1 AMH amh NN cord-028721-x6f26ahr 151 2 regulation regulation NN cord-028721-x6f26ahr 151 3 is be VBZ cord-028721-x6f26ahr 151 4 incompletely incompletely RB cord-028721-x6f26ahr 151 5 understood understand VBN cord-028721-x6f26ahr 151 6 . . . cord-028721-x6f26ahr 152 1 Its -PRON- PRP$ cord-028721-x6f26ahr 152 2 expression expression NN cord-028721-x6f26ahr 152 3 is be VBZ cord-028721-x6f26ahr 152 4 controlled control VBN cord-028721-x6f26ahr 152 5 by by IN cord-028721-x6f26ahr 152 6 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 152 7 factor factor NN cord-028721-x6f26ahr 152 8 1 1 CD cord-028721-x6f26ahr 152 9 ( ( -LRB- cord-028721-x6f26ahr 152 10 SF-1 SF-1 NNP cord-028721-x6f26ahr 152 11 ) ) -RRB- cord-028721-x6f26ahr 152 12 , , , cord-028721-x6f26ahr 152 13 also also RB cord-028721-x6f26ahr 152 14 called call VBN cord-028721-x6f26ahr 152 15 Ad4BP Ad4BP NNP cord-028721-x6f26ahr 152 16 , , , cord-028721-x6f26ahr 152 17 46 46 CD cord-028721-x6f26ahr 152 18 which which WDT cord-028721-x6f26ahr 152 19 is be VBZ cord-028721-x6f26ahr 152 20 an an DT cord-028721-x6f26ahr 152 21 orphan orphan NN cord-028721-x6f26ahr 152 22 nuclear nuclear JJ cord-028721-x6f26ahr 152 23 receptor receptor NN cord-028721-x6f26ahr 152 24 that that WDT cord-028721-x6f26ahr 152 25 acts act VBZ cord-028721-x6f26ahr 152 26 as as IN cord-028721-x6f26ahr 152 27 a a DT cord-028721-x6f26ahr 152 28 transcriptional transcriptional JJ cord-028721-x6f26ahr 152 29 regulator regulator NN cord-028721-x6f26ahr 152 30 of of IN cord-028721-x6f26ahr 152 31 all all DT cord-028721-x6f26ahr 152 32 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 152 33 genes gene NNS cord-028721-x6f26ahr 152 34 . . . cord-028721-x6f26ahr 153 1 AMH AMH NNP cord-028721-x6f26ahr 153 2 regulates regulate VBZ cord-028721-x6f26ahr 153 3 SRY SRY NNP cord-028721-x6f26ahr 153 4 expression expression NN cord-028721-x6f26ahr 153 5 , , , cord-028721-x6f26ahr 153 6 which which WDT cord-028721-x6f26ahr 153 7 in in IN cord-028721-x6f26ahr 153 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 153 9 cells cell NNS cord-028721-x6f26ahr 153 10 is be VBZ cord-028721-x6f26ahr 153 11 detected detect VBN cord-028721-x6f26ahr 153 12 immediately immediately RB cord-028721-x6f26ahr 153 13 before before IN cord-028721-x6f26ahr 153 14 AMH amh NN cord-028721-x6f26ahr 153 15 expression expression NN cord-028721-x6f26ahr 153 16 . . . cord-028721-x6f26ahr 154 1 47 47 CD cord-028721-x6f26ahr 155 1 During during IN cord-028721-x6f26ahr 155 2 puberty puberty NN cord-028721-x6f26ahr 155 3 , , , cord-028721-x6f26ahr 155 4 AMH AMH NNP cord-028721-x6f26ahr 155 5 is be VBZ cord-028721-x6f26ahr 155 6 negatively negatively RB cord-028721-x6f26ahr 155 7 regulated regulate VBN cord-028721-x6f26ahr 155 8 by by IN cord-028721-x6f26ahr 155 9 androgens androgen NNS cord-028721-x6f26ahr 155 10 . . . cord-028721-x6f26ahr 156 1 48 48 CD cord-028721-x6f26ahr 156 2 AMH amh NN cord-028721-x6f26ahr 156 3 acts act VBZ cord-028721-x6f26ahr 156 4 on on IN cord-028721-x6f26ahr 156 5 the the DT cord-028721-x6f26ahr 156 6 testis testis NN cord-028721-x6f26ahr 156 7 , , , cord-028721-x6f26ahr 156 8 genital genital JJ cord-028721-x6f26ahr 156 9 tract tract NN cord-028721-x6f26ahr 156 10 , , , cord-028721-x6f26ahr 156 11 and and CC cord-028721-x6f26ahr 156 12 extragenital extragenital JJ cord-028721-x6f26ahr 156 13 structures structure NNS cord-028721-x6f26ahr 156 14 . . . cord-028721-x6f26ahr 157 1 It -PRON- PRP cord-028721-x6f26ahr 157 2 causes cause VBZ cord-028721-x6f26ahr 157 3 involution involution NN cord-028721-x6f26ahr 157 4 of of IN cord-028721-x6f26ahr 157 5 the the DT cord-028721-x6f26ahr 157 6 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 157 7 müllerian müllerian JJ cord-028721-x6f26ahr 157 8 duct duct NN cord-028721-x6f26ahr 157 9 . . . cord-028721-x6f26ahr 158 1 Action action NN cord-028721-x6f26ahr 158 2 begins begin VBZ cord-028721-x6f26ahr 158 3 at at IN cord-028721-x6f26ahr 158 4 the the DT cord-028721-x6f26ahr 158 5 caudal caudal NNP cord-028721-x6f26ahr 158 6 testicular testicular JJ cord-028721-x6f26ahr 158 7 pole pole NN cord-028721-x6f26ahr 158 8 and and CC cord-028721-x6f26ahr 158 9 progresses progress VBZ cord-028721-x6f26ahr 158 10 rapidly rapidly RB cord-028721-x6f26ahr 158 11 . . . cord-028721-x6f26ahr 159 1 In in IN cord-028721-x6f26ahr 159 2 adults adult NNS cord-028721-x6f26ahr 159 3 , , , cord-028721-x6f26ahr 159 4 remnants remnant NNS cord-028721-x6f26ahr 159 5 of of IN cord-028721-x6f26ahr 159 6 the the DT cord-028721-x6f26ahr 159 7 müllerian müllerian JJ cord-028721-x6f26ahr 159 8 ducts duct NNS cord-028721-x6f26ahr 159 9 include include VBP cord-028721-x6f26ahr 159 10 the the DT cord-028721-x6f26ahr 159 11 appendix appendix NN cord-028721-x6f26ahr 159 12 testis testis NN cord-028721-x6f26ahr 159 13 at at IN cord-028721-x6f26ahr 159 14 the the DT cord-028721-x6f26ahr 159 15 cranial cranial JJ cord-028721-x6f26ahr 159 16 end end NN cord-028721-x6f26ahr 159 17 and and CC cord-028721-x6f26ahr 159 18 the the DT cord-028721-x6f26ahr 159 19 prostatic prostatic JJ cord-028721-x6f26ahr 159 20 utricle utricle NN cord-028721-x6f26ahr 159 21 ( ( -LRB- cord-028721-x6f26ahr 159 22 verumontanum verumontanum NNP cord-028721-x6f26ahr 159 23 ) ) -RRB- cord-028721-x6f26ahr 159 24 at at IN cord-028721-x6f26ahr 159 25 the the DT cord-028721-x6f26ahr 159 26 caudal caudal JJ cord-028721-x6f26ahr 159 27 end end NN cord-028721-x6f26ahr 159 28 . . . cord-028721-x6f26ahr 160 1 AMH AMH NNP cord-028721-x6f26ahr 160 2 also also RB cord-028721-x6f26ahr 160 3 stimulates stimulate VBZ cord-028721-x6f26ahr 160 4 development development NN cord-028721-x6f26ahr 160 5 of of IN cord-028721-x6f26ahr 160 6 the the DT cord-028721-x6f26ahr 160 7 tunica tunica NNP cord-028721-x6f26ahr 160 8 albuginea albuginea NNP cord-028721-x6f26ahr 160 9 , , , cord-028721-x6f26ahr 160 10 formed form VBN cord-028721-x6f26ahr 160 11 by by IN cord-028721-x6f26ahr 160 12 insertion insertion NN cord-028721-x6f26ahr 160 13 of of IN cord-028721-x6f26ahr 160 14 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 160 15 between between IN cord-028721-x6f26ahr 160 16 the the DT cord-028721-x6f26ahr 160 17 celomic celomic JJ cord-028721-x6f26ahr 160 18 epithelium epithelium NN cord-028721-x6f26ahr 160 19 and and CC cord-028721-x6f26ahr 160 20 primordial primordial JJ cord-028721-x6f26ahr 160 21 sex sex NN cord-028721-x6f26ahr 160 22 cords cord NNS cord-028721-x6f26ahr 160 23 . . . cord-028721-x6f26ahr 161 1 This this DT cord-028721-x6f26ahr 161 2 mesenchyma mesenchyma NN cord-028721-x6f26ahr 161 3 is be VBZ cord-028721-x6f26ahr 161 4 also also RB cord-028721-x6f26ahr 161 5 the the DT cord-028721-x6f26ahr 161 6 origin origin NN cord-028721-x6f26ahr 161 7 of of IN cord-028721-x6f26ahr 161 8 collagenized collagenized JJ cord-028721-x6f26ahr 161 9 connective connective JJ cord-028721-x6f26ahr 161 10 tissue tissue NN cord-028721-x6f26ahr 161 11 , , , cord-028721-x6f26ahr 161 12 with with IN cord-028721-x6f26ahr 161 13 deposition deposition NN cord-028721-x6f26ahr 161 14 of of IN cord-028721-x6f26ahr 161 15 collagen collagen NN cord-028721-x6f26ahr 161 16 fi fi NNP cord-028721-x6f26ahr 161 17 bers ber NNS cord-028721-x6f26ahr 161 18 in in IN cord-028721-x6f26ahr 161 19 several several JJ cord-028721-x6f26ahr 161 20 layers layer NNS cord-028721-x6f26ahr 161 21 that that WDT cord-028721-x6f26ahr 161 22 parallel parallel VBP cord-028721-x6f26ahr 161 23 the the DT cord-028721-x6f26ahr 161 24 testicular testicular NN cord-028721-x6f26ahr 161 25 surface surface NN cord-028721-x6f26ahr 161 26 . . . cord-028721-x6f26ahr 162 1 49 49 CD cord-028721-x6f26ahr 162 2 AMH amh NN cord-028721-x6f26ahr 162 3 also also RB cord-028721-x6f26ahr 162 4 hinders hinder VBZ cord-028721-x6f26ahr 162 5 the the DT cord-028721-x6f26ahr 162 6 entry entry NN cord-028721-x6f26ahr 162 7 of of IN cord-028721-x6f26ahr 162 8 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 162 9 in in IN cord-028721-x6f26ahr 162 10 meiosis meiosis NN cord-028721-x6f26ahr 162 11 . . . cord-028721-x6f26ahr 163 1 50 50 CD cord-028721-x6f26ahr 164 1 The the DT cord-028721-x6f26ahr 164 2 best well RBS cord-028721-x6f26ahr 164 3 - - HYPH cord-028721-x6f26ahr 164 4 known know VBN cord-028721-x6f26ahr 164 5 function function NN cord-028721-x6f26ahr 164 6 of of IN cord-028721-x6f26ahr 164 7 AMH AMH NNP cord-028721-x6f26ahr 164 8 in in IN cord-028721-x6f26ahr 164 9 the the DT cord-028721-x6f26ahr 164 10 extragonadal extragonadal JJ cord-028721-x6f26ahr 164 11 system system NN cord-028721-x6f26ahr 164 12 is be VBZ cord-028721-x6f26ahr 164 13 the the DT cord-028721-x6f26ahr 164 14 maturation maturation NN cord-028721-x6f26ahr 164 15 of of IN cord-028721-x6f26ahr 164 16 fetal fetal JJ cord-028721-x6f26ahr 164 17 lungs lung NNS cord-028721-x6f26ahr 164 18 . . . cord-028721-x6f26ahr 165 1 51 51 CD cord-028721-x6f26ahr 166 1 Testosterone testosterone NN cord-028721-x6f26ahr 166 2 is be VBZ cord-028721-x6f26ahr 166 3 synthesized synthesize VBN cord-028721-x6f26ahr 166 4 by by IN cord-028721-x6f26ahr 166 5 the the DT cord-028721-x6f26ahr 166 6 Leydig Leydig NNP cord-028721-x6f26ahr 166 7 cells cell NNS cord-028721-x6f26ahr 166 8 . . . cord-028721-x6f26ahr 167 1 These these DT cord-028721-x6f26ahr 167 2 fi fi NN cord-028721-x6f26ahr 167 3 rst rst NN cord-028721-x6f26ahr 167 4 appear appear VBP cord-028721-x6f26ahr 167 5 among among IN cord-028721-x6f26ahr 167 6 the the DT cord-028721-x6f26ahr 167 7 sex sex NN cord-028721-x6f26ahr 167 8 cords cord NNS cord-028721-x6f26ahr 167 9 in in IN cord-028721-x6f26ahr 167 10 the the DT cord-028721-x6f26ahr 167 11 eighth eighth JJ cord-028721-x6f26ahr 167 12 week week NN cord-028721-x6f26ahr 167 13 of of IN cord-028721-x6f26ahr 167 14 gestation gestation NN cord-028721-x6f26ahr 167 15 , , , cord-028721-x6f26ahr 167 16 and and CC cord-028721-x6f26ahr 167 17 their -PRON- PRP$ cord-028721-x6f26ahr 167 18 number number NN cord-028721-x6f26ahr 167 19 increases increase NNS cord-028721-x6f26ahr 167 20 to to IN cord-028721-x6f26ahr 167 21 48 48 CD cord-028721-x6f26ahr 167 22 million million CD cord-028721-x6f26ahr 167 23 per per IN cord-028721-x6f26ahr 167 24 pair pair NN cord-028721-x6f26ahr 167 25 of of IN cord-028721-x6f26ahr 167 26 testes testis NNS cord-028721-x6f26ahr 167 27 by by IN cord-028721-x6f26ahr 167 28 the the DT cord-028721-x6f26ahr 167 29 16th 16th JJ cord-028721-x6f26ahr 167 30 week week NN cord-028721-x6f26ahr 167 31 , , , cord-028721-x6f26ahr 167 32 52 52 CD cord-028721-x6f26ahr 167 33 occupying occupy VBG cord-028721-x6f26ahr 167 34 about about IN cord-028721-x6f26ahr 167 35 50 50 CD cord-028721-x6f26ahr 167 36 % % NN cord-028721-x6f26ahr 167 37 of of IN cord-028721-x6f26ahr 167 38 the the DT cord-028721-x6f26ahr 167 39 testicular testicular JJ cord-028721-x6f26ahr 167 40 volume volume NN cord-028721-x6f26ahr 167 41 ( ( -LRB- cord-028721-x6f26ahr 167 42 Fig Fig NNP cord-028721-x6f26ahr 167 43 . . . cord-028721-x6f26ahr 167 44 12 12 CD cord-028721-x6f26ahr 167 45 - - SYM cord-028721-x6f26ahr 167 46 6 6 CD cord-028721-x6f26ahr 167 47 ) ) -RRB- cord-028721-x6f26ahr 167 48 . . . cord-028721-x6f26ahr 168 1 The the DT cord-028721-x6f26ahr 168 2 relative relative JJ cord-028721-x6f26ahr 168 3 number number NN cord-028721-x6f26ahr 168 4 of of IN cord-028721-x6f26ahr 168 5 Leydig Leydig NNP cord-028721-x6f26ahr 168 6 cells cell NNS cord-028721-x6f26ahr 168 7 decreases decrease VBZ cord-028721-x6f26ahr 168 8 from from IN cord-028721-x6f26ahr 168 9 the the DT cord-028721-x6f26ahr 168 10 16th 16th NN cord-028721-x6f26ahr 168 11 to to IN cord-028721-x6f26ahr 168 12 the the DT cord-028721-x6f26ahr 168 13 24th 24th JJ cord-028721-x6f26ahr 168 14 week week NN cord-028721-x6f26ahr 168 15 , , , cord-028721-x6f26ahr 168 16 owing owe VBG cord-028721-x6f26ahr 168 17 to to IN cord-028721-x6f26ahr 168 18 rapid rapid JJ cord-028721-x6f26ahr 168 19 enlargement enlargement NN cord-028721-x6f26ahr 168 20 of of IN cord-028721-x6f26ahr 168 21 the the DT cord-028721-x6f26ahr 168 22 testis testis NN cord-028721-x6f26ahr 168 23 during during IN cord-028721-x6f26ahr 168 24 this this DT cord-028721-x6f26ahr 168 25 period period NN cord-028721-x6f26ahr 168 26 . . . cord-028721-x6f26ahr 169 1 However however RB cord-028721-x6f26ahr 169 2 , , , cord-028721-x6f26ahr 169 3 the the DT cord-028721-x6f26ahr 169 4 absolute absolute JJ cord-028721-x6f26ahr 169 5 number number NN cord-028721-x6f26ahr 169 6 of of IN cord-028721-x6f26ahr 169 7 Leydig Leydig NNP cord-028721-x6f26ahr 169 8 cells cell NNS cord-028721-x6f26ahr 169 9 remains remain VBZ cord-028721-x6f26ahr 169 10 constant constant JJ cord-028721-x6f26ahr 169 11 . . . cord-028721-x6f26ahr 170 1 From from IN cord-028721-x6f26ahr 170 2 the the DT cord-028721-x6f26ahr 170 3 24th 24th JJ cord-028721-x6f26ahr 170 4 week week NN cord-028721-x6f26ahr 170 5 to to IN cord-028721-x6f26ahr 170 6 birth birth VB cord-028721-x6f26ahr 170 7 , , , cord-028721-x6f26ahr 170 8 the the DT cord-028721-x6f26ahr 170 9 number number NN cord-028721-x6f26ahr 170 10 of of IN cord-028721-x6f26ahr 170 11 Leydig Leydig NNP cord-028721-x6f26ahr 170 12 cells cell NNS cord-028721-x6f26ahr 170 13 decreases decrease VBZ cord-028721-x6f26ahr 170 14 to to IN cord-028721-x6f26ahr 170 15 18 18 CD cord-028721-x6f26ahr 170 16 million million CD cord-028721-x6f26ahr 170 17 per per IN cord-028721-x6f26ahr 170 18 pair pair NN cord-028721-x6f26ahr 170 19 of of IN cord-028721-x6f26ahr 170 20 testes testis NNS cord-028721-x6f26ahr 170 21 . . . cord-028721-x6f26ahr 171 1 Testosterone testosterone NN cord-028721-x6f26ahr 171 2 synthesis synthesis NN cord-028721-x6f26ahr 171 3 begins begin VBZ cord-028721-x6f26ahr 171 4 after after IN cord-028721-x6f26ahr 171 5 the the DT cord-028721-x6f26ahr 171 6 56th 56th JJ cord-028721-x6f26ahr 171 7 day day NN cord-028721-x6f26ahr 171 8 of of IN cord-028721-x6f26ahr 171 9 gestation gestation NN cord-028721-x6f26ahr 171 10 . . . cord-028721-x6f26ahr 172 1 Testosterone testosterone NN cord-028721-x6f26ahr 172 2 secretion secretion NN cord-028721-x6f26ahr 172 3 is be VBZ cord-028721-x6f26ahr 172 4 regulated regulate VBN cord-028721-x6f26ahr 172 5 by by IN cord-028721-x6f26ahr 172 6 hCG hCG NNP cord-028721-x6f26ahr 172 7 and and CC cord-028721-x6f26ahr 172 8 LH LH NNP cord-028721-x6f26ahr 172 9 concentrations concentration NNS cord-028721-x6f26ahr 172 10 . . . cord-028721-x6f26ahr 173 1 hCG hCG NNP cord-028721-x6f26ahr 173 2 peaks peak NNS cord-028721-x6f26ahr 173 3 between between IN cord-028721-x6f26ahr 173 4 weeks week NNS cord-028721-x6f26ahr 173 5 11 11 CD cord-028721-x6f26ahr 173 6 and and CC cord-028721-x6f26ahr 173 7 17 17 CD cord-028721-x6f26ahr 173 8 and and CC cord-028721-x6f26ahr 173 9 drops drop VBZ cord-028721-x6f26ahr 173 10 markedly markedly RB cord-028721-x6f26ahr 173 11 thereafter thereafter RB cord-028721-x6f26ahr 174 1 ; ; : cord-028721-x6f26ahr 174 2 hCG hcg JJ cord-028721-x6f26ahr 174 3 - - HYPH cord-028721-x6f26ahr 174 4 dependent dependent JJ cord-028721-x6f26ahr 174 5 testosterone testosterone NN cord-028721-x6f26ahr 174 6 is be VBZ cord-028721-x6f26ahr 174 7 the the DT cord-028721-x6f26ahr 174 8 most most RBS cord-028721-x6f26ahr 174 9 important important JJ cord-028721-x6f26ahr 174 10 determinant determinant NN cord-028721-x6f26ahr 174 11 of of IN cord-028721-x6f26ahr 174 12 genital genital JJ cord-028721-x6f26ahr 174 13 differentiation differentiation NN cord-028721-x6f26ahr 174 14 . . . cord-028721-x6f26ahr 175 1 Wolffian wolffian JJ cord-028721-x6f26ahr 175 2 duct duct NN cord-028721-x6f26ahr 175 3 differentiation differentiation NN cord-028721-x6f26ahr 175 4 occurs occur VBZ cord-028721-x6f26ahr 175 5 only only RB cord-028721-x6f26ahr 175 6 as as IN cord-028721-x6f26ahr 175 7 a a DT cord-028721-x6f26ahr 175 8 response response NN cord-028721-x6f26ahr 175 9 to to IN cord-028721-x6f26ahr 175 10 the the DT cord-028721-x6f26ahr 175 11 testosterone testosterone NN cord-028721-x6f26ahr 175 12 secreted secrete VBN cord-028721-x6f26ahr 175 13 by by IN cord-028721-x6f26ahr 175 14 the the DT cord-028721-x6f26ahr 175 15 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 175 16 testis testis NN cord-028721-x6f26ahr 175 17 . . . cord-028721-x6f26ahr 176 1 This this DT cord-028721-x6f26ahr 176 2 secretion secretion NN cord-028721-x6f26ahr 176 3 stimulates stimulate VBZ cord-028721-x6f26ahr 176 4 differentiation differentiation NN cord-028721-x6f26ahr 176 5 of of IN cord-028721-x6f26ahr 176 6 the the DT cord-028721-x6f26ahr 176 7 ductus ductus NNP cord-028721-x6f26ahr 176 8 epididymidis epididymidis NN cord-028721-x6f26ahr 176 9 , , , cord-028721-x6f26ahr 176 10 ductus ductus NN cord-028721-x6f26ahr 176 11 deferens deferen NNS cord-028721-x6f26ahr 176 12 , , , cord-028721-x6f26ahr 176 13 and and CC cord-028721-x6f26ahr 176 14 seminal seminal JJ cord-028721-x6f26ahr 176 15 vesicle vesicle NN cord-028721-x6f26ahr 176 16 . . . cord-028721-x6f26ahr 177 1 Anomalies anomaly NNS cord-028721-x6f26ahr 177 2 in in IN cord-028721-x6f26ahr 177 3 androgen androgen NN cord-028721-x6f26ahr 177 4 synthesis synthesis NN cord-028721-x6f26ahr 177 5 lead lead NN cord-028721-x6f26ahr 177 6 to to IN cord-028721-x6f26ahr 177 7 incomplete incomplete JJ cord-028721-x6f26ahr 177 8 masculinization masculinization NN cord-028721-x6f26ahr 177 9 and and CC cord-028721-x6f26ahr 177 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 177 11 . . . cord-028721-x6f26ahr 178 1 Dihydrotestosterone Dihydrotestosterone NNP cord-028721-x6f26ahr 178 2 ( ( -LRB- cord-028721-x6f26ahr 178 3 DHT DHT NNP cord-028721-x6f26ahr 178 4 ) ) -RRB- cord-028721-x6f26ahr 178 5 derives derive VBZ cord-028721-x6f26ahr 178 6 from from IN cord-028721-x6f26ahr 178 7 testosterone testosterone NN cord-028721-x6f26ahr 178 8 by by IN cord-028721-x6f26ahr 178 9 the the DT cord-028721-x6f26ahr 178 10 action action NN cord-028721-x6f26ahr 178 11 of of IN cord-028721-x6f26ahr 178 12 the the DT cord-028721-x6f26ahr 178 13 enzyme enzyme NN cord-028721-x6f26ahr 178 14 5α 5α CD cord-028721-x6f26ahr 178 15 - - HYPH cord-028721-x6f26ahr 178 16 reductase reductase NN cord-028721-x6f26ahr 178 17 and and CC cord-028721-x6f26ahr 178 18 is be VBZ cord-028721-x6f26ahr 178 19 responsible responsible JJ cord-028721-x6f26ahr 178 20 for for IN cord-028721-x6f26ahr 178 21 differentiation differentiation NN cord-028721-x6f26ahr 178 22 of of IN cord-028721-x6f26ahr 178 23 the the DT cord-028721-x6f26ahr 178 24 prostate prostate NN cord-028721-x6f26ahr 178 25 and and CC cord-028721-x6f26ahr 178 26 the the DT cord-028721-x6f26ahr 178 27 development development NN cord-028721-x6f26ahr 178 28 of of IN cord-028721-x6f26ahr 178 29 the the DT cord-028721-x6f26ahr 178 30 external external JJ cord-028721-x6f26ahr 178 31 genitalia genitalia NNS cord-028721-x6f26ahr 178 32 , , , cord-028721-x6f26ahr 178 33 male male JJ cord-028721-x6f26ahr 178 34 urethra urethra NN cord-028721-x6f26ahr 178 35 , , , cord-028721-x6f26ahr 178 36 penis penis NN cord-028721-x6f26ahr 178 37 and and CC cord-028721-x6f26ahr 178 38 scrotum scrotum NN cord-028721-x6f26ahr 178 39 . . . cord-028721-x6f26ahr 179 1 It -PRON- PRP cord-028721-x6f26ahr 179 2 induces induce VBZ cord-028721-x6f26ahr 179 3 fusion fusion NN cord-028721-x6f26ahr 179 4 of of IN cord-028721-x6f26ahr 179 5 the the DT cord-028721-x6f26ahr 179 6 labioscrotal labioscrotal JJ cord-028721-x6f26ahr 179 7 folds fold VBZ cord-028721-x6f26ahr 179 8 in in IN cord-028721-x6f26ahr 179 9 the the DT cord-028721-x6f26ahr 179 10 middle middle JJ cord-028721-x6f26ahr 179 11 plane plane NN cord-028721-x6f26ahr 179 12 to to TO cord-028721-x6f26ahr 179 13 form form VB cord-028721-x6f26ahr 179 14 the the DT cord-028721-x6f26ahr 179 15 scrotum scrotum NN cord-028721-x6f26ahr 179 16 and and CC cord-028721-x6f26ahr 179 17 the the DT cord-028721-x6f26ahr 179 18 middle middle JJ cord-028721-x6f26ahr 179 19 scrotal scrotal JJ cord-028721-x6f26ahr 179 20 raphe raphe NN cord-028721-x6f26ahr 179 21 . . . cord-028721-x6f26ahr 180 1 The the DT cord-028721-x6f26ahr 180 2 urethral urethral JJ cord-028721-x6f26ahr 180 3 folds fold NNS cord-028721-x6f26ahr 180 4 become become VBP cord-028721-x6f26ahr 180 5 fused fuse VBN cord-028721-x6f26ahr 180 6 to to TO cord-028721-x6f26ahr 180 7 form form VB cord-028721-x6f26ahr 180 8 the the DT cord-028721-x6f26ahr 180 9 penile penile JJ cord-028721-x6f26ahr 180 10 urethra urethra NN cord-028721-x6f26ahr 180 11 . . . cord-028721-x6f26ahr 181 1 The the DT cord-028721-x6f26ahr 181 2 genital genital JJ cord-028721-x6f26ahr 181 3 tubercle tubercle NN cord-028721-x6f26ahr 181 4 enlarges enlarge VBZ cord-028721-x6f26ahr 181 5 to to TO cord-028721-x6f26ahr 181 6 form form VB cord-028721-x6f26ahr 181 7 the the DT cord-028721-x6f26ahr 181 8 glans glans NN cord-028721-x6f26ahr 181 9 penis penis NN cord-028721-x6f26ahr 181 10 . . . cord-028721-x6f26ahr 182 1 An an DT cord-028721-x6f26ahr 182 2 ectodermal ectodermal JJ cord-028721-x6f26ahr 182 3 invagination invagination NN cord-028721-x6f26ahr 182 4 of of IN cord-028721-x6f26ahr 182 5 the the DT cord-028721-x6f26ahr 182 6 glans glans NNP cord-028721-x6f26ahr 182 7 tip tip NN cord-028721-x6f26ahr 182 8 forms form VBZ cord-028721-x6f26ahr 182 9 the the DT cord-028721-x6f26ahr 182 10 terminal terminal JJ cord-028721-x6f26ahr 182 11 portion portion NN cord-028721-x6f26ahr 182 12 of of IN cord-028721-x6f26ahr 182 13 the the DT cord-028721-x6f26ahr 182 14 urethra urethra NN cord-028721-x6f26ahr 182 15 . . . cord-028721-x6f26ahr 183 1 The the DT cord-028721-x6f26ahr 183 2 urogenital urogenital JJ cord-028721-x6f26ahr 183 3 sinus sinus NN cord-028721-x6f26ahr 183 4 gives give VBZ cord-028721-x6f26ahr 183 5 rise rise NN cord-028721-x6f26ahr 183 6 to to IN cord-028721-x6f26ahr 183 7 the the DT cord-028721-x6f26ahr 183 8 urinary urinary JJ cord-028721-x6f26ahr 183 9 bladder bladder NN cord-028721-x6f26ahr 183 10 , , , cord-028721-x6f26ahr 183 11 prostatic prostatic JJ cord-028721-x6f26ahr 183 12 urethra urethra NN cord-028721-x6f26ahr 183 13 , , , cord-028721-x6f26ahr 183 14 and and CC cord-028721-x6f26ahr 183 15 prostate prostate NN cord-028721-x6f26ahr 183 16 . . . cord-028721-x6f26ahr 184 1 53 53 CD cord-028721-x6f26ahr 185 1 The the DT cord-028721-x6f26ahr 185 2 initial initial JJ cord-028721-x6f26ahr 185 3 effects effect NNS cord-028721-x6f26ahr 185 4 of of IN cord-028721-x6f26ahr 185 5 DHT DHT NNP cord-028721-x6f26ahr 185 6 ( ( -LRB- cord-028721-x6f26ahr 185 7 labioscrotal labioscrotal JJ cord-028721-x6f26ahr 185 8 fusion fusion NN cord-028721-x6f26ahr 185 9 ) ) -RRB- cord-028721-x6f26ahr 185 10 occur occur VBP cord-028721-x6f26ahr 185 11 on on IN cord-028721-x6f26ahr 185 12 approximately approximately RB cord-028721-x6f26ahr 185 13 day day NN cord-028721-x6f26ahr 185 14 70 70 CD cord-028721-x6f26ahr 185 15 ; ; : cord-028721-x6f26ahr 185 16 the the DT cord-028721-x6f26ahr 185 17 urethral urethral JJ cord-028721-x6f26ahr 185 18 groove groove NN cord-028721-x6f26ahr 185 19 is be VBZ cord-028721-x6f26ahr 185 20 closed close VBN cord-028721-x6f26ahr 185 21 on on IN cord-028721-x6f26ahr 185 22 about about IN cord-028721-x6f26ahr 185 23 day day NN cord-028721-x6f26ahr 185 24 74 74 CD cord-028721-x6f26ahr 185 25 ; ; : cord-028721-x6f26ahr 185 26 and and CC cord-028721-x6f26ahr 185 27 the the DT cord-028721-x6f26ahr 185 28 external external JJ cord-028721-x6f26ahr 185 29 genitalia genitalia NNS cord-028721-x6f26ahr 185 30 are be VBP cord-028721-x6f26ahr 185 31 completely completely RB cord-028721-x6f26ahr 185 32 developed develop VBN cord-028721-x6f26ahr 185 33 by by IN cord-028721-x6f26ahr 185 34 week week NN cord-028721-x6f26ahr 185 35 20 20 CD cord-028721-x6f26ahr 185 36 . . . cord-028721-x6f26ahr 186 1 The the DT cord-028721-x6f26ahr 186 2 actions action NNS cord-028721-x6f26ahr 186 3 of of IN cord-028721-x6f26ahr 186 4 these these DT cord-028721-x6f26ahr 186 5 hormones hormone NNS cord-028721-x6f26ahr 186 6 occur occur VBP cord-028721-x6f26ahr 186 7 at at IN cord-028721-x6f26ahr 186 8 precise precise JJ cord-028721-x6f26ahr 186 9 moments moment NNS cord-028721-x6f26ahr 186 10 in in IN cord-028721-x6f26ahr 186 11 development development NN cord-028721-x6f26ahr 186 12 . . . cord-028721-x6f26ahr 187 1 Failure failure NN cord-028721-x6f26ahr 187 2 in in IN cord-028721-x6f26ahr 187 3 the the DT cord-028721-x6f26ahr 187 4 amount amount NN cord-028721-x6f26ahr 187 5 or or CC cord-028721-x6f26ahr 187 6 timing timing NN cord-028721-x6f26ahr 187 7 of of IN cord-028721-x6f26ahr 187 8 secretion secretion NN cord-028721-x6f26ahr 187 9 or or CC cord-028721-x6f26ahr 187 10 in in IN cord-028721-x6f26ahr 187 11 the the DT cord-028721-x6f26ahr 187 12 responsiveness responsiveness NN cord-028721-x6f26ahr 187 13 of of IN cord-028721-x6f26ahr 187 14 target target NN cord-028721-x6f26ahr 187 15 tissues tissue NNS cord-028721-x6f26ahr 187 16 causes cause VBZ cord-028721-x6f26ahr 187 17 most most JJS cord-028721-x6f26ahr 187 18 of of IN cord-028721-x6f26ahr 187 19 the the DT cord-028721-x6f26ahr 187 20 malformations malformation NNS cord-028721-x6f26ahr 187 21 found find VBN cord-028721-x6f26ahr 187 22 in in IN cord-028721-x6f26ahr 187 23 intersex intersex NN cord-028721-x6f26ahr 187 24 conditions condition NNS cord-028721-x6f26ahr 187 25 . . . cord-028721-x6f26ahr 188 1 52 52 CD cord-028721-x6f26ahr 188 2 FSH fsh NN cord-028721-x6f26ahr 188 3 and and CC cord-028721-x6f26ahr 188 4 LH LH NNP cord-028721-x6f26ahr 188 5 both both DT cord-028721-x6f26ahr 188 6 play play VBP cord-028721-x6f26ahr 188 7 an an DT cord-028721-x6f26ahr 188 8 important important JJ cord-028721-x6f26ahr 188 9 role role NN cord-028721-x6f26ahr 188 10 in in IN cord-028721-x6f26ahr 188 11 the the DT cord-028721-x6f26ahr 188 12 last last JJ cord-028721-x6f26ahr 188 13 months month NNS cord-028721-x6f26ahr 188 14 of of IN cord-028721-x6f26ahr 188 15 gestation gestation NN cord-028721-x6f26ahr 188 16 . . . cord-028721-x6f26ahr 189 1 LH LH NNP cord-028721-x6f26ahr 189 2 appears appear VBZ cord-028721-x6f26ahr 189 3 in in IN cord-028721-x6f26ahr 189 4 the the DT cord-028721-x6f26ahr 189 5 fetal fetal JJ cord-028721-x6f26ahr 189 6 circulation circulation NN cord-028721-x6f26ahr 189 7 during during IN cord-028721-x6f26ahr 189 8 the the DT cord-028721-x6f26ahr 189 9 10th 10th JJ cord-028721-x6f26ahr 189 10 week week NN cord-028721-x6f26ahr 189 11 and and CC cord-028721-x6f26ahr 189 12 peaks peak NNS cord-028721-x6f26ahr 189 13 by by IN cord-028721-x6f26ahr 189 14 the the DT cord-028721-x6f26ahr 189 15 18th 18th NN cord-028721-x6f26ahr 189 16 , , , cord-028721-x6f26ahr 189 17 decreasing decrease VBG cord-028721-x6f26ahr 189 18 progressively progressively RB cord-028721-x6f26ahr 189 19 and and CC cord-028721-x6f26ahr 189 20 slowly slowly RB cord-028721-x6f26ahr 189 21 thereafter thereafter RB cord-028721-x6f26ahr 189 22 until until IN cord-028721-x6f26ahr 189 23 birth birth NN cord-028721-x6f26ahr 189 24 . . . cord-028721-x6f26ahr 190 1 LH LH NNP cord-028721-x6f26ahr 190 2 chiefl chiefl NNP cord-028721-x6f26ahr 190 3 y y NNP cord-028721-x6f26ahr 190 4 regulates regulate VBZ cord-028721-x6f26ahr 190 5 androgen androgen NN cord-028721-x6f26ahr 190 6 production production NN cord-028721-x6f26ahr 190 7 during during IN cord-028721-x6f26ahr 190 8 the the DT cord-028721-x6f26ahr 190 9 second second JJ cord-028721-x6f26ahr 190 10 half half NN cord-028721-x6f26ahr 190 11 of of IN cord-028721-x6f26ahr 190 12 fetal fetal JJ cord-028721-x6f26ahr 190 13 life life NN cord-028721-x6f26ahr 190 14 . . . cord-028721-x6f26ahr 191 1 FSH FSH NNP cord-028721-x6f26ahr 191 2 is be VBZ cord-028721-x6f26ahr 191 3 an an DT cord-028721-x6f26ahr 191 4 essential essential JJ cord-028721-x6f26ahr 191 5 mitogen mitogen NN cord-028721-x6f26ahr 191 6 for for IN cord-028721-x6f26ahr 191 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 191 8 cells cell NNS cord-028721-x6f26ahr 191 9 that that WDT cord-028721-x6f26ahr 191 10 reach reach VBP cord-028721-x6f26ahr 191 11 the the DT cord-028721-x6f26ahr 191 12 highest high JJS cord-028721-x6f26ahr 191 13 mitotic mitotic JJ cord-028721-x6f26ahr 191 14 ratio ratio NN cord-028721-x6f26ahr 191 15 at at IN cord-028721-x6f26ahr 191 16 the the DT cord-028721-x6f26ahr 191 17 end end NN cord-028721-x6f26ahr 191 18 of of IN cord-028721-x6f26ahr 191 19 fetal fetal JJ cord-028721-x6f26ahr 191 20 life life NN cord-028721-x6f26ahr 192 1 ( ( -LRB- cord-028721-x6f26ahr 192 2 Fig Fig NNP cord-028721-x6f26ahr 192 3 . . . cord-028721-x6f26ahr 192 4 12 12 CD cord-028721-x6f26ahr 192 5 - - SYM cord-028721-x6f26ahr 192 6 7 7 CD cord-028721-x6f26ahr 192 7 ) ) -RRB- cord-028721-x6f26ahr 192 8 . . . cord-028721-x6f26ahr 193 1 54 54 CD cord-028721-x6f26ahr 193 2 , , , cord-028721-x6f26ahr 193 3 55 55 CD cord-028721-x6f26ahr 193 4 Testicular Testicular NNP cord-028721-x6f26ahr 193 5 descent descent NN cord-028721-x6f26ahr 193 6 Testicular Testicular NNP cord-028721-x6f26ahr 193 7 descent descent NN cord-028721-x6f26ahr 193 8 is be VBZ cord-028721-x6f26ahr 193 9 the the DT cord-028721-x6f26ahr 193 10 result result NN cord-028721-x6f26ahr 193 11 of of IN cord-028721-x6f26ahr 193 12 hormonal hormonal JJ cord-028721-x6f26ahr 193 13 and and CC cord-028721-x6f26ahr 193 14 mechanical mechanical JJ cord-028721-x6f26ahr 193 15 actions action NNS cord-028721-x6f26ahr 193 16 that that WDT cord-028721-x6f26ahr 193 17 are be VBP cord-028721-x6f26ahr 193 18 not not RB cord-028721-x6f26ahr 193 19 fully fully RB cord-028721-x6f26ahr 193 20 understood understand VBN cord-028721-x6f26ahr 193 21 . . . cord-028721-x6f26ahr 194 1 Three three CD cord-028721-x6f26ahr 194 2 steps step NNS cord-028721-x6f26ahr 194 3 are be VBP cord-028721-x6f26ahr 194 4 recognized recognize VBN cord-028721-x6f26ahr 194 5 : : : cord-028721-x6f26ahr 194 6 nephric nephric NNP cord-028721-x6f26ahr 194 7 displacement displacement NN cord-028721-x6f26ahr 194 8 , , , cord-028721-x6f26ahr 194 9 transabdominal transabdominal JJ cord-028721-x6f26ahr 194 10 descent descent NN cord-028721-x6f26ahr 194 11 , , , cord-028721-x6f26ahr 194 12 and and CC cord-028721-x6f26ahr 194 13 inguinal inguinal JJ cord-028721-x6f26ahr 194 14 descent descent NN cord-028721-x6f26ahr 194 15 . . . cord-028721-x6f26ahr 195 1 In in IN cord-028721-x6f26ahr 195 2 nephric nephric JJ cord-028721-x6f26ahr 195 3 displacement displacement NN cord-028721-x6f26ahr 195 4 , , , cord-028721-x6f26ahr 195 5 the the DT cord-028721-x6f26ahr 195 6 gonad gonad NN cord-028721-x6f26ahr 195 7 detaches detach VBZ cord-028721-x6f26ahr 195 8 from from IN cord-028721-x6f26ahr 195 9 the the DT cord-028721-x6f26ahr 195 10 metanephros metanephros NNP cord-028721-x6f26ahr 195 11 in in IN cord-028721-x6f26ahr 195 12 the the DT cord-028721-x6f26ahr 195 13 seventh seventh JJ cord-028721-x6f26ahr 195 14 week week NN cord-028721-x6f26ahr 195 15 of of IN cord-028721-x6f26ahr 195 16 gestation gestation NN cord-028721-x6f26ahr 195 17 . . . cord-028721-x6f26ahr 196 1 Transabdominal Transabdominal NNP cord-028721-x6f26ahr 196 2 descent descent NN cord-028721-x6f26ahr 196 3 occurs occur VBZ cord-028721-x6f26ahr 196 4 in in IN cord-028721-x6f26ahr 196 5 the the DT cord-028721-x6f26ahr 196 6 12th 12th JJ cord-028721-x6f26ahr 196 7 week week NN cord-028721-x6f26ahr 196 8 and and CC cord-028721-x6f26ahr 196 9 consists consist VBZ cord-028721-x6f26ahr 196 10 of of IN cord-028721-x6f26ahr 196 11 the the DT cord-028721-x6f26ahr 196 12 displacement displacement NN cord-028721-x6f26ahr 196 13 of of IN cord-028721-x6f26ahr 196 14 the the DT cord-028721-x6f26ahr 196 15 testis testis NN cord-028721-x6f26ahr 196 16 towards towards IN cord-028721-x6f26ahr 196 17 the the DT cord-028721-x6f26ahr 196 18 deep deep JJ cord-028721-x6f26ahr 196 19 inguinal inguinal JJ cord-028721-x6f26ahr 196 20 ring ring NN cord-028721-x6f26ahr 196 21 . . . cord-028721-x6f26ahr 197 1 Inguinal inguinal JJ cord-028721-x6f26ahr 197 2 descent descent NN cord-028721-x6f26ahr 197 3 occurs occur VBZ cord-028721-x6f26ahr 197 4 between between IN cord-028721-x6f26ahr 197 5 the the DT cord-028721-x6f26ahr 197 6 seventh seventh JJ cord-028721-x6f26ahr 197 7 month month NN cord-028721-x6f26ahr 197 8 and and CC cord-028721-x6f26ahr 197 9 birth birth NN cord-028721-x6f26ahr 197 10 . . . cord-028721-x6f26ahr 198 1 56 56 CD cord-028721-x6f26ahr 199 1 Clinically clinically RB cord-028721-x6f26ahr 199 2 , , , cord-028721-x6f26ahr 199 3 the the DT cord-028721-x6f26ahr 199 4 term term NN cord-028721-x6f26ahr 199 5 testicular testicular JJ cord-028721-x6f26ahr 199 6 descent descent NN cord-028721-x6f26ahr 199 7 often often RB cord-028721-x6f26ahr 199 8 refers refer VBZ cord-028721-x6f26ahr 199 9 only only RB cord-028721-x6f26ahr 199 10 to to IN cord-028721-x6f26ahr 199 11 this this DT cord-028721-x6f26ahr 199 12 last last JJ cord-028721-x6f26ahr 199 13 step step NN cord-028721-x6f26ahr 199 14 , , , cord-028721-x6f26ahr 199 15 in in IN cord-028721-x6f26ahr 199 16 which which WDT cord-028721-x6f26ahr 199 17 the the DT cord-028721-x6f26ahr 199 18 testis testis NN cord-028721-x6f26ahr 199 19 passes pass VBZ cord-028721-x6f26ahr 199 20 from from IN cord-028721-x6f26ahr 199 21 the the DT cord-028721-x6f26ahr 199 22 abdominal abdominal JJ cord-028721-x6f26ahr 199 23 cavity cavity NN cord-028721-x6f26ahr 199 24 to to IN cord-028721-x6f26ahr 199 25 the the DT cord-028721-x6f26ahr 199 26 scrotum scrotum NN cord-028721-x6f26ahr 199 27 . . . cord-028721-x6f26ahr 200 1 Testicular testicular JJ cord-028721-x6f26ahr 200 2 descent descent NN cord-028721-x6f26ahr 200 3 is be VBZ cord-028721-x6f26ahr 200 4 directed direct VBN cord-028721-x6f26ahr 200 5 by by IN cord-028721-x6f26ahr 200 6 the the DT cord-028721-x6f26ahr 200 7 gubernaculum gubernaculum NNP cord-028721-x6f26ahr 200 8 testis testis NN cord-028721-x6f26ahr 200 9 , , , cord-028721-x6f26ahr 200 10 a a DT cord-028721-x6f26ahr 200 11 structure structure NN cord-028721-x6f26ahr 200 12 that that WDT cord-028721-x6f26ahr 200 13 appears appear VBZ cord-028721-x6f26ahr 200 14 in in IN cord-028721-x6f26ahr 200 15 the the DT cord-028721-x6f26ahr 200 16 sixth sixth JJ cord-028721-x6f26ahr 200 17 week week NN cord-028721-x6f26ahr 200 18 as as IN cord-028721-x6f26ahr 200 19 an an DT cord-028721-x6f26ahr 200 20 elongate elongate JJ cord-028721-x6f26ahr 200 21 condensation condensation NN cord-028721-x6f26ahr 200 22 of of IN cord-028721-x6f26ahr 200 23 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 200 24 cells cell NNS cord-028721-x6f26ahr 200 25 extending extend VBG cord-028721-x6f26ahr 200 26 from from IN cord-028721-x6f26ahr 200 27 the the DT cord-028721-x6f26ahr 200 28 genital genital JJ cord-028721-x6f26ahr 200 29 ridge ridge NN cord-028721-x6f26ahr 200 30 to to IN cord-028721-x6f26ahr 200 31 the the DT cord-028721-x6f26ahr 200 32 presumptive presumptive JJ cord-028721-x6f26ahr 200 33 inguinal inguinal JJ cord-028721-x6f26ahr 200 34 region region NN cord-028721-x6f26ahr 200 35 . . . cord-028721-x6f26ahr 201 1 57 57 CD cord-028721-x6f26ahr 201 2 , , , cord-028721-x6f26ahr 201 3 58 58 CD cord-028721-x6f26ahr 202 1 At at IN cord-028721-x6f26ahr 202 2 this this DT cord-028721-x6f26ahr 202 3 level level NN cord-028721-x6f26ahr 202 4 in in IN cord-028721-x6f26ahr 202 5 the the DT cord-028721-x6f26ahr 202 6 abdominal abdominal JJ cord-028721-x6f26ahr 202 7 wall wall NN cord-028721-x6f26ahr 202 8 , , , cord-028721-x6f26ahr 202 9 the the DT cord-028721-x6f26ahr 202 10 gubernaculum gubernaculum NN cord-028721-x6f26ahr 202 11 cells cell NNS cord-028721-x6f26ahr 202 12 persist persist VBP cord-028721-x6f26ahr 202 13 as as IN cord-028721-x6f26ahr 202 14 a a DT cord-028721-x6f26ahr 202 15 simple simple JJ cord-028721-x6f26ahr 202 16 mesenchyma mesenchyma NN cord-028721-x6f26ahr 202 17 while while IN cord-028721-x6f26ahr 202 18 the the DT cord-028721-x6f26ahr 202 19 remaining remain VBG cord-028721-x6f26ahr 202 20 abdominal abdominal JJ cord-028721-x6f26ahr 202 21 wall wall NN cord-028721-x6f26ahr 202 22 cells cell NNS cord-028721-x6f26ahr 202 23 differentiate differentiate VBP cord-028721-x6f26ahr 202 24 into into IN cord-028721-x6f26ahr 202 25 muscle muscle NN cord-028721-x6f26ahr 202 26 . . . cord-028721-x6f26ahr 203 1 These these DT cord-028721-x6f26ahr 203 2 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 203 3 cells cell NNS cord-028721-x6f26ahr 203 4 give give VBP cord-028721-x6f26ahr 203 5 rise rise NN cord-028721-x6f26ahr 203 6 to to IN cord-028721-x6f26ahr 203 7 the the DT cord-028721-x6f26ahr 203 8 inguinal inguinal JJ cord-028721-x6f26ahr 203 9 canal canal NN cord-028721-x6f26ahr 203 10 . . . cord-028721-x6f26ahr 204 1 Thus thus RB cord-028721-x6f26ahr 204 2 , , , cord-028721-x6f26ahr 204 3 the the DT cord-028721-x6f26ahr 204 4 testis testis NN cord-028721-x6f26ahr 204 5 lies lie VBZ cord-028721-x6f26ahr 204 6 on on IN cord-028721-x6f26ahr 204 7 a a DT cord-028721-x6f26ahr 204 8 continuous continuous JJ cord-028721-x6f26ahr 204 9 column column NN cord-028721-x6f26ahr 204 10 of of IN cord-028721-x6f26ahr 204 11 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 204 12 limited limit VBN cord-028721-x6f26ahr 204 13 by by IN cord-028721-x6f26ahr 204 14 the the DT cord-028721-x6f26ahr 204 15 cranial cranial JJ cord-028721-x6f26ahr 204 16 testicular testicular JJ cord-028721-x6f26ahr 204 17 ligament ligament NN cord-028721-x6f26ahr 204 18 in in IN cord-028721-x6f26ahr 204 19 the the DT cord-028721-x6f26ahr 204 20 upper upper JJ cord-028721-x6f26ahr 204 21 pole pole NN cord-028721-x6f26ahr 204 22 and and CC cord-028721-x6f26ahr 204 23 by by IN cord-028721-x6f26ahr 204 24 the the DT cord-028721-x6f26ahr 204 25 plica plica NNP cord-028721-x6f26ahr 204 26 gubernaculi gubernaculi NNP cord-028721-x6f26ahr 204 27 that that WDT cord-028721-x6f26ahr 204 28 joins join VBZ cord-028721-x6f26ahr 204 29 the the DT cord-028721-x6f26ahr 204 30 testis testis NN cord-028721-x6f26ahr 204 31 to to IN cord-028721-x6f26ahr 204 32 the the DT cord-028721-x6f26ahr 204 33 future future JJ cord-028721-x6f26ahr 204 34 scrotal scrotal JJ cord-028721-x6f26ahr 204 35 region region NN cord-028721-x6f26ahr 204 36 in in IN cord-028721-x6f26ahr 204 37 the the DT cord-028721-x6f26ahr 204 38 inferior inferior JJ cord-028721-x6f26ahr 204 39 pole pole NN cord-028721-x6f26ahr 204 40 . . . cord-028721-x6f26ahr 205 1 The the DT cord-028721-x6f26ahr 205 2 periphery periphery NN cord-028721-x6f26ahr 205 3 of of IN cord-028721-x6f26ahr 205 4 this this DT cord-028721-x6f26ahr 205 5 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 205 6 tissue tissue NN cord-028721-x6f26ahr 205 7 is be VBZ cord-028721-x6f26ahr 205 8 invaded invade VBN cord-028721-x6f26ahr 205 9 by by IN cord-028721-x6f26ahr 205 10 the the DT cord-028721-x6f26ahr 205 11 processus processus NNP cord-028721-x6f26ahr 205 12 vaginalis vaginalis NNP cord-028721-x6f26ahr 205 13 , , , cord-028721-x6f26ahr 205 14 which which WDT cord-028721-x6f26ahr 205 15 develops develop VBZ cord-028721-x6f26ahr 205 16 from from IN cord-028721-x6f26ahr 205 17 a a DT cord-028721-x6f26ahr 205 18 peritoneal peritoneal JJ cord-028721-x6f26ahr 205 19 pouch pouch NN cord-028721-x6f26ahr 205 20 that that WDT cord-028721-x6f26ahr 205 21 grows grow VBZ cord-028721-x6f26ahr 205 22 into into IN cord-028721-x6f26ahr 205 23 this this DT cord-028721-x6f26ahr 205 24 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 205 25 . . . cord-028721-x6f26ahr 206 1 Once once IN cord-028721-x6f26ahr 206 2 the the DT cord-028721-x6f26ahr 206 3 inguinal inguinal JJ cord-028721-x6f26ahr 206 4 canal canal NN cord-028721-x6f26ahr 206 5 and and CC cord-028721-x6f26ahr 206 6 the the DT cord-028721-x6f26ahr 206 7 plica plica NNP cord-028721-x6f26ahr 206 8 gubernaculi gubernaculi NNP cord-028721-x6f26ahr 206 9 are be VBP cord-028721-x6f26ahr 206 10 formed form VBN cord-028721-x6f26ahr 206 11 , , , cord-028721-x6f26ahr 206 12 development development NN cord-028721-x6f26ahr 206 13 slows slow VBZ cord-028721-x6f26ahr 206 14 . . . cord-028721-x6f26ahr 207 1 In in IN cord-028721-x6f26ahr 207 2 the the DT cord-028721-x6f26ahr 207 3 seventh seventh JJ cord-028721-x6f26ahr 207 4 month month NN cord-028721-x6f26ahr 207 5 the the DT cord-028721-x6f26ahr 207 6 processus processus NNP cord-028721-x6f26ahr 207 7 vaginalis vaginalis NNP cord-028721-x6f26ahr 207 8 undergoes undergo VBZ cord-028721-x6f26ahr 207 9 active active JJ cord-028721-x6f26ahr 207 10 growth growth NN cord-028721-x6f26ahr 207 11 , , , cord-028721-x6f26ahr 207 12 the the DT cord-028721-x6f26ahr 207 13 cremasteric cremasteric JJ cord-028721-x6f26ahr 207 14 muscle muscle NN cord-028721-x6f26ahr 207 15 develops develop VBZ cord-028721-x6f26ahr 207 16 from from IN cord-028721-x6f26ahr 207 17 the the DT cord-028721-x6f26ahr 207 18 mesenchyma mesenchyma NNP cord-028721-x6f26ahr 207 19 outside outside IN cord-028721-x6f26ahr 207 20 the the DT cord-028721-x6f26ahr 207 21 processus processus NNP cord-028721-x6f26ahr 207 22 vaginalis vaginalis NNP cord-028721-x6f26ahr 207 23 , , , cord-028721-x6f26ahr 207 24 and and CC cord-028721-x6f26ahr 207 25 the the DT cord-028721-x6f26ahr 207 26 distal distal JJ cord-028721-x6f26ahr 207 27 end end NN cord-028721-x6f26ahr 207 28 of of IN cord-028721-x6f26ahr 207 29 the the DT cord-028721-x6f26ahr 207 30 gubernaculum gubernaculum NN cord-028721-x6f26ahr 207 31 enlarges enlarge VBZ cord-028721-x6f26ahr 207 32 markedly markedly RB cord-028721-x6f26ahr 207 33 . . . cord-028721-x6f26ahr 208 1 Gubernacular gubernacular JJ cord-028721-x6f26ahr 208 2 enlargement enlargement NN cord-028721-x6f26ahr 208 3 occurs occur VBZ cord-028721-x6f26ahr 208 4 from from IN cord-028721-x6f26ahr 208 5 the the DT cord-028721-x6f26ahr 208 6 16th 16th NN cord-028721-x6f26ahr 208 7 to to IN cord-028721-x6f26ahr 208 8 the the DT cord-028721-x6f26ahr 208 9 24th 24th JJ cord-028721-x6f26ahr 208 10 weeks week NNS cord-028721-x6f26ahr 208 11 of of IN cord-028721-x6f26ahr 208 12 gestation gestation NN cord-028721-x6f26ahr 208 13 period period NN cord-028721-x6f26ahr 208 14 and and CC cord-028721-x6f26ahr 208 15 is be VBZ cord-028721-x6f26ahr 208 16 caused cause VBN cord-028721-x6f26ahr 208 17 by by IN cord-028721-x6f26ahr 208 18 hyperplasia hyperplasia NN cord-028721-x6f26ahr 208 19 , , , cord-028721-x6f26ahr 208 20 hypertrophy hypertrophy NN cord-028721-x6f26ahr 208 21 , , , cord-028721-x6f26ahr 208 22 and and CC cord-028721-x6f26ahr 208 23 the the DT cord-028721-x6f26ahr 208 24 absorption absorption NN cord-028721-x6f26ahr 208 25 of of IN cord-028721-x6f26ahr 208 26 a a DT cord-028721-x6f26ahr 208 27 great great JJ cord-028721-x6f26ahr 208 28 volume volume NN cord-028721-x6f26ahr 208 29 of of IN cord-028721-x6f26ahr 208 30 water water NN cord-028721-x6f26ahr 208 31 by by IN cord-028721-x6f26ahr 208 32 the the DT cord-028721-x6f26ahr 208 33 glycosaminoglycans glycosaminoglycan NNS cord-028721-x6f26ahr 208 34 of of IN cord-028721-x6f26ahr 208 35 the the DT cord-028721-x6f26ahr 208 36 matrix matrix NN cord-028721-x6f26ahr 208 37 . . . cord-028721-x6f26ahr 209 1 59 59 CD cord-028721-x6f26ahr 210 1 The the DT cord-028721-x6f26ahr 210 2 tissue tissue NN cord-028721-x6f26ahr 210 3 is be VBZ cord-028721-x6f26ahr 210 4 reminiscent reminiscent JJ cord-028721-x6f26ahr 210 5 of of IN cord-028721-x6f26ahr 210 6 Wharton Wharton NNP cord-028721-x6f26ahr 210 7 's 's POS cord-028721-x6f26ahr 210 8 jelly jelly NN cord-028721-x6f26ahr 210 9 of of IN cord-028721-x6f26ahr 210 10 the the DT cord-028721-x6f26ahr 210 11 umbilical umbilical JJ cord-028721-x6f26ahr 210 12 cord cord NN cord-028721-x6f26ahr 210 13 . . . cord-028721-x6f26ahr 211 1 By by IN cord-028721-x6f26ahr 211 2 this this DT cord-028721-x6f26ahr 211 3 time time NN cord-028721-x6f26ahr 211 4 , , , cord-028721-x6f26ahr 211 5 the the DT cord-028721-x6f26ahr 211 6 testis testis NN cord-028721-x6f26ahr 211 7 - - HYPH cord-028721-x6f26ahr 211 8 epididymis epididymis NN cord-028721-x6f26ahr 211 9 complex complex NN cord-028721-x6f26ahr 211 10 is be VBZ cord-028721-x6f26ahr 211 11 pear pear NN cord-028721-x6f26ahr 211 12 - - HYPH cord-028721-x6f26ahr 211 13 shaped shaped JJ cord-028721-x6f26ahr 211 14 and and CC cord-028721-x6f26ahr 211 15 its -PRON- PRP$ cord-028721-x6f26ahr 211 16 largest large JJS cord-028721-x6f26ahr 211 17 component component NN cord-028721-x6f26ahr 211 18 is be VBZ cord-028721-x6f26ahr 211 19 the the DT cord-028721-x6f26ahr 211 20 gubernaculum gubernaculum NN cord-028721-x6f26ahr 211 21 . . . cord-028721-x6f26ahr 212 1 The the DT cord-028721-x6f26ahr 212 2 testis testis NN cord-028721-x6f26ahr 212 3 and and CC cord-028721-x6f26ahr 212 4 epididymis epididymis NN cord-028721-x6f26ahr 212 5 slide slide VBP cord-028721-x6f26ahr 212 6 through through IN cord-028721-x6f26ahr 212 7 the the DT cord-028721-x6f26ahr 212 8 inguinal inguinal JJ cord-028721-x6f26ahr 212 9 canal canal NN cord-028721-x6f26ahr 212 10 behind behind IN cord-028721-x6f26ahr 212 11 the the DT cord-028721-x6f26ahr 212 12 gubernaculum gubernaculum NN cord-028721-x6f26ahr 212 13 . . . cord-028721-x6f26ahr 213 1 Simultaneously simultaneously RB cord-028721-x6f26ahr 213 2 , , , cord-028721-x6f26ahr 213 3 development development NN cord-028721-x6f26ahr 213 4 of of IN cord-028721-x6f26ahr 213 5 the the DT cord-028721-x6f26ahr 213 6 processus processus NNP cord-028721-x6f26ahr 213 7 vaginalis vaginalis NNP cord-028721-x6f26ahr 213 8 is be VBZ cord-028721-x6f26ahr 213 9 completed complete VBN cord-028721-x6f26ahr 213 10 and and CC cord-028721-x6f26ahr 213 11 the the DT cord-028721-x6f26ahr 213 12 gubernaculum gubernaculum NN cord-028721-x6f26ahr 213 13 begins begin VBZ cord-028721-x6f26ahr 213 14 to to TO cord-028721-x6f26ahr 213 15 shorten shorten VB cord-028721-x6f26ahr 213 16 , , , cord-028721-x6f26ahr 213 17 the the DT cord-028721-x6f26ahr 213 18 epididymis epididymis NN cord-028721-x6f26ahr 213 19 develops develop VBZ cord-028721-x6f26ahr 213 20 further further RB cord-028721-x6f26ahr 213 21 , , , cord-028721-x6f26ahr 213 22 and and CC cord-028721-x6f26ahr 213 23 the the DT cord-028721-x6f26ahr 213 24 testicular testicular JJ cord-028721-x6f26ahr 213 25 blood blood NN cord-028721-x6f26ahr 213 26 vessels vessel NNS cord-028721-x6f26ahr 213 27 and and CC cord-028721-x6f26ahr 213 28 vas vas NNP cord-028721-x6f26ahr 213 29 deferens deferen NNS cord-028721-x6f26ahr 213 30 lengthen lengthen VBP cord-028721-x6f26ahr 213 31 . . . cord-028721-x6f26ahr 214 1 60 60 CD cord-028721-x6f26ahr 214 2 Testicular Testicular NNP cord-028721-x6f26ahr 214 3 descent descent NN cord-028721-x6f26ahr 214 4 is be VBZ cord-028721-x6f26ahr 214 5 a a DT cord-028721-x6f26ahr 214 6 complex complex JJ cord-028721-x6f26ahr 214 7 process process NN cord-028721-x6f26ahr 214 8 integrating integrate VBG cord-028721-x6f26ahr 214 9 several several JJ cord-028721-x6f26ahr 214 10 essential essential JJ cord-028721-x6f26ahr 214 11 factors factor NNS cord-028721-x6f26ahr 214 12 , , , cord-028721-x6f26ahr 214 13 including include VBG cord-028721-x6f26ahr 214 14 normal normal JJ cord-028721-x6f26ahr 214 15 function function NN cord-028721-x6f26ahr 214 16 of of IN cord-028721-x6f26ahr 214 17 the the DT cord-028721-x6f26ahr 214 18 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 214 19 - - HYPH cord-028721-x6f26ahr 214 20 testicular testicular JJ cord-028721-x6f26ahr 214 21 axis axis NN cord-028721-x6f26ahr 214 22 , , , cord-028721-x6f26ahr 214 23 normal normal JJ cord-028721-x6f26ahr 214 24 development development NN cord-028721-x6f26ahr 214 25 of of IN cord-028721-x6f26ahr 214 26 abdominal abdominal JJ cord-028721-x6f26ahr 214 27 musculature musculature NN cord-028721-x6f26ahr 214 28 , , , cord-028721-x6f26ahr 214 29 gubernaculum gubernaculum NN cord-028721-x6f26ahr 214 30 and and CC cord-028721-x6f26ahr 214 31 the the DT cord-028721-x6f26ahr 214 32 processus processus NNP cord-028721-x6f26ahr 214 33 vaginalis vaginalis NNP cord-028721-x6f26ahr 214 34 , , , cord-028721-x6f26ahr 214 35 61 61 CD cord-028721-x6f26ahr 214 36 , , , cord-028721-x6f26ahr 214 37 62 62 CD cord-028721-x6f26ahr 214 38 and and CC cord-028721-x6f26ahr 214 39 a a DT cord-028721-x6f26ahr 214 40 testis testis NN cord-028721-x6f26ahr 214 41 with with IN cord-028721-x6f26ahr 214 42 normal normal JJ cord-028721-x6f26ahr 214 43 endocrine endocrine JJ cord-028721-x6f26ahr 214 44 function function NN cord-028721-x6f26ahr 214 45 . . . cord-028721-x6f26ahr 215 1 The the DT cord-028721-x6f26ahr 215 2 critical critical JJ cord-028721-x6f26ahr 215 3 role role NN cord-028721-x6f26ahr 215 4 of of IN cord-028721-x6f26ahr 215 5 normal normal JJ cord-028721-x6f26ahr 215 6 hormonal hormonal JJ cord-028721-x6f26ahr 215 7 function function NN cord-028721-x6f26ahr 215 8 is be VBZ cord-028721-x6f26ahr 215 9 supported support VBN cord-028721-x6f26ahr 215 10 by by IN cord-028721-x6f26ahr 215 11 clinical clinical JJ cord-028721-x6f26ahr 215 12 and and CC cord-028721-x6f26ahr 215 13 experimental experimental JJ cord-028721-x6f26ahr 215 14 observations observation NNS cord-028721-x6f26ahr 215 15 : : : cord-028721-x6f26ahr 215 16 destruction destruction NN cord-028721-x6f26ahr 215 17 of of IN cord-028721-x6f26ahr 215 18 the the DT cord-028721-x6f26ahr 215 19 hypophysis hypophysis NN cord-028721-x6f26ahr 215 20 in in IN cord-028721-x6f26ahr 215 21 laboratory laboratory NN cord-028721-x6f26ahr 215 22 animals animal NNS cord-028721-x6f26ahr 215 23 impedes impede VBZ cord-028721-x6f26ahr 215 24 testicular testicular JJ cord-028721-x6f26ahr 215 25 descent descent NN cord-028721-x6f26ahr 215 26 ; ; , cord-028721-x6f26ahr 215 27 anencephalic anencephalic JJ cord-028721-x6f26ahr 215 28 fetuses fetus NNS cord-028721-x6f26ahr 215 29 usually usually RB cord-028721-x6f26ahr 215 30 have have VBP cord-028721-x6f26ahr 215 31 undescended undescended JJ cord-028721-x6f26ahr 215 32 testes testis NNS cord-028721-x6f26ahr 215 33 ; ; : cord-028721-x6f26ahr 215 34 many many JJ cord-028721-x6f26ahr 215 35 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 215 36 patients patient NNS cord-028721-x6f26ahr 215 37 have have VBP cord-028721-x6f26ahr 215 38 transitory transitory JJ cord-028721-x6f26ahr 215 39 neonatal neonatal JJ cord-028721-x6f26ahr 215 40 hypogonadotropic hypogonadotropic JJ cord-028721-x6f26ahr 215 41 hypogonadism hypogonadism NN cord-028721-x6f26ahr 215 42 ; ; : cord-028721-x6f26ahr 215 43 and and CC cord-028721-x6f26ahr 215 44 some some DT cord-028721-x6f26ahr 215 45 undescended undescended JJ cord-028721-x6f26ahr 215 46 testes testis NNS cord-028721-x6f26ahr 215 47 descend descend VBP cord-028721-x6f26ahr 215 48 after after IN cord-028721-x6f26ahr 215 49 treatment treatment NN cord-028721-x6f26ahr 215 50 with with IN cord-028721-x6f26ahr 215 51 human human JJ cord-028721-x6f26ahr 215 52 chorionic chorionic JJ cord-028721-x6f26ahr 215 53 gonadotropin gonadotropin NN cord-028721-x6f26ahr 215 54 or or CC cord-028721-x6f26ahr 215 55 gonadotropin gonadotropin NN cord-028721-x6f26ahr 215 56 - - HYPH cord-028721-x6f26ahr 215 57 releasing release VBG cord-028721-x6f26ahr 215 58 hormone hormone NN cord-028721-x6f26ahr 215 59 . . . cord-028721-x6f26ahr 216 1 Adequate adequate JJ cord-028721-x6f26ahr 216 2 intra intra JJ cord-028721-x6f26ahr 216 3 - - JJ cord-028721-x6f26ahr 216 4 abdominal abdominal JJ cord-028721-x6f26ahr 216 5 pressure pressure NN cord-028721-x6f26ahr 216 6 is be VBZ cord-028721-x6f26ahr 216 7 another another DT cord-028721-x6f26ahr 216 8 requisite requisite JJ cord-028721-x6f26ahr 216 9 . . . cord-028721-x6f26ahr 217 1 63 63 CD cord-028721-x6f26ahr 217 2 , , , cord-028721-x6f26ahr 217 3 64 64 CD cord-028721-x6f26ahr 218 1 In in IN cord-028721-x6f26ahr 218 2 the the DT cord-028721-x6f26ahr 218 3 prune prune NN cord-028721-x6f26ahr 218 4 - - HYPH cord-028721-x6f26ahr 218 5 belly belly NN cord-028721-x6f26ahr 218 6 syndrome syndrome NN cord-028721-x6f26ahr 218 7 , , , cord-028721-x6f26ahr 218 8 bilateral bilateral JJ cord-028721-x6f26ahr 218 9 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 218 10 is be VBZ cord-028721-x6f26ahr 218 11 associated associate VBN cord-028721-x6f26ahr 218 12 with with IN cord-028721-x6f26ahr 218 13 urologic urologic JJ cord-028721-x6f26ahr 218 14 malformations malformation NNS cord-028721-x6f26ahr 218 15 and and CC cord-028721-x6f26ahr 218 16 absence absence NN cord-028721-x6f26ahr 218 17 of of IN cord-028721-x6f26ahr 218 18 the the DT cord-028721-x6f26ahr 218 19 abdominal abdominal JJ cord-028721-x6f26ahr 218 20 wall wall NN cord-028721-x6f26ahr 218 21 musculature musculature NN cord-028721-x6f26ahr 218 22 . . . cord-028721-x6f26ahr 219 1 In in IN cord-028721-x6f26ahr 219 2 a a DT cord-028721-x6f26ahr 219 3 variant variant NN cord-028721-x6f26ahr 219 4 of of IN cord-028721-x6f26ahr 219 5 this this DT cord-028721-x6f26ahr 219 6 syndrome syndrome NN cord-028721-x6f26ahr 219 7 , , , cord-028721-x6f26ahr 219 8 termed term VBN cord-028721-x6f26ahr 219 9 pseudo pseudo JJ cord-028721-x6f26ahr 219 10 - - JJ cord-028721-x6f26ahr 219 11 prune prune NN cord-028721-x6f26ahr 219 12 - - HYPH cord-028721-x6f26ahr 219 13 belly belly NN cord-028721-x6f26ahr 219 14 syndrome syndrome NN cord-028721-x6f26ahr 219 15 , , , cord-028721-x6f26ahr 219 16 there there EX cord-028721-x6f26ahr 219 17 is be VBZ cord-028721-x6f26ahr 219 18 a a DT cord-028721-x6f26ahr 219 19 positive positive JJ cord-028721-x6f26ahr 219 20 correlation correlation NN cord-028721-x6f26ahr 219 21 between between IN cord-028721-x6f26ahr 219 22 the the DT cord-028721-x6f26ahr 219 23 development development NN cord-028721-x6f26ahr 219 24 of of IN cord-028721-x6f26ahr 219 25 the the DT cord-028721-x6f26ahr 219 26 abdominal abdominal JJ cord-028721-x6f26ahr 219 27 wall wall NN cord-028721-x6f26ahr 219 28 musculature musculature NN cord-028721-x6f26ahr 219 29 and and CC cord-028721-x6f26ahr 219 30 testicular testicular JJ cord-028721-x6f26ahr 219 31 descent descent NN cord-028721-x6f26ahr 219 32 . . . cord-028721-x6f26ahr 220 1 Development development NN cord-028721-x6f26ahr 220 2 of of IN cord-028721-x6f26ahr 220 3 the the DT cord-028721-x6f26ahr 220 4 processus processus NNP cord-028721-x6f26ahr 220 5 vaginalis vaginalis NNP cord-028721-x6f26ahr 220 6 also also RB cord-028721-x6f26ahr 220 7 plays play VBZ cord-028721-x6f26ahr 220 8 a a DT cord-028721-x6f26ahr 220 9 critical critical JJ cord-028721-x6f26ahr 220 10 role role NN cord-028721-x6f26ahr 220 11 in in IN cord-028721-x6f26ahr 220 12 testicular testicular JJ cord-028721-x6f26ahr 220 13 descent descent NN cord-028721-x6f26ahr 220 14 . . . cord-028721-x6f26ahr 221 1 This this DT cord-028721-x6f26ahr 221 2 structure structure NN cord-028721-x6f26ahr 221 3 grows grow VBZ cord-028721-x6f26ahr 221 4 within within IN cord-028721-x6f26ahr 221 5 the the DT cord-028721-x6f26ahr 221 6 gubernaculum gubernaculum NN cord-028721-x6f26ahr 221 7 ; ; : cord-028721-x6f26ahr 221 8 if if IN cord-028721-x6f26ahr 221 9 it -PRON- PRP cord-028721-x6f26ahr 221 10 is be VBZ cord-028721-x6f26ahr 221 11 partially partially RB cord-028721-x6f26ahr 221 12 replaced replace VBN cord-028721-x6f26ahr 221 13 by by IN cord-028721-x6f26ahr 221 14 fi fi NN cord-028721-x6f26ahr 221 15 brous brous JJ cord-028721-x6f26ahr 221 16 tissue tissue NN cord-028721-x6f26ahr 221 17 , , , cord-028721-x6f26ahr 221 18 the the DT cord-028721-x6f26ahr 221 19 testis testis NN cord-028721-x6f26ahr 221 20 will will MD cord-028721-x6f26ahr 221 21 follow follow VB cord-028721-x6f26ahr 221 22 other other JJ cord-028721-x6f26ahr 221 23 directions direction NNS cord-028721-x6f26ahr 221 24 in in IN cord-028721-x6f26ahr 221 25 its -PRON- PRP$ cord-028721-x6f26ahr 221 26 descent descent NN cord-028721-x6f26ahr 221 27 and and CC cord-028721-x6f26ahr 221 28 end end VB cord-028721-x6f26ahr 221 29 in in IN cord-028721-x6f26ahr 221 30 an an DT cord-028721-x6f26ahr 221 31 ectopic ectopic JJ cord-028721-x6f26ahr 221 32 location location NN cord-028721-x6f26ahr 221 33 . . . cord-028721-x6f26ahr 222 1 If if IN cord-028721-x6f26ahr 222 2 fi fi NN cord-028721-x6f26ahr 222 3 brous brous JJ cord-028721-x6f26ahr 222 4 tissue tissue NN cord-028721-x6f26ahr 222 5 completely completely RB cord-028721-x6f26ahr 222 6 replaces replace VBZ cord-028721-x6f26ahr 222 7 the the DT cord-028721-x6f26ahr 222 8 gubernaculum gubernaculum NN cord-028721-x6f26ahr 222 9 , , , cord-028721-x6f26ahr 222 10 the the DT cord-028721-x6f26ahr 222 11 processus processus NNP cord-028721-x6f26ahr 222 12 vaginalis vaginalis NNP cord-028721-x6f26ahr 222 13 and and CC cord-028721-x6f26ahr 222 14 cremasteric cremasteric JJ cord-028721-x6f26ahr 222 15 muscle muscle NN cord-028721-x6f26ahr 222 16 fail fail VBP cord-028721-x6f26ahr 222 17 to to TO cord-028721-x6f26ahr 222 18 develop develop VB cord-028721-x6f26ahr 222 19 fully fully RB cord-028721-x6f26ahr 222 20 , , , cord-028721-x6f26ahr 222 21 and and CC cord-028721-x6f26ahr 222 22 descent descent NN cord-028721-x6f26ahr 222 23 of of IN cord-028721-x6f26ahr 222 24 the the DT cord-028721-x6f26ahr 222 25 testis testis NN cord-028721-x6f26ahr 222 26 is be VBZ cord-028721-x6f26ahr 222 27 mechanically mechanically RB cord-028721-x6f26ahr 222 28 blocked block VBN cord-028721-x6f26ahr 222 29 . . . cord-028721-x6f26ahr 223 1 62 62 CD cord-028721-x6f26ahr 224 1 The the DT cord-028721-x6f26ahr 224 2 hormonal hormonal JJ cord-028721-x6f26ahr 224 3 requirements requirement NNS cord-028721-x6f26ahr 224 4 for for IN cord-028721-x6f26ahr 224 5 testicular testicular JJ cord-028721-x6f26ahr 224 6 descent descent NN cord-028721-x6f26ahr 224 7 are be VBP cord-028721-x6f26ahr 224 8 not not RB cord-028721-x6f26ahr 224 9 clear clear JJ cord-028721-x6f26ahr 224 10 . . . cord-028721-x6f26ahr 225 1 65 65 CD cord-028721-x6f26ahr 226 1 The the DT cord-028721-x6f26ahr 226 2 most most RBS cord-028721-x6f26ahr 226 3 important important JJ cord-028721-x6f26ahr 226 4 factor factor NN cord-028721-x6f26ahr 226 5 in in IN cord-028721-x6f26ahr 226 6 transabdominal transabdominal JJ cord-028721-x6f26ahr 226 7 descent descent NN cord-028721-x6f26ahr 226 8 is be VBZ cord-028721-x6f26ahr 226 9 the the DT cord-028721-x6f26ahr 226 10 androgen androgen NN cord-028721-x6f26ahr 226 11 - - HYPH cord-028721-x6f26ahr 226 12 independent independent JJ cord-028721-x6f26ahr 226 13 peptide peptide JJ cord-028721-x6f26ahr 226 14 insulin insulin NN cord-028721-x6f26ahr 226 15 - - HYPH cord-028721-x6f26ahr 226 16 like like JJ cord-028721-x6f26ahr 226 17 factor factor NN cord-028721-x6f26ahr 226 18 3 3 CD cord-028721-x6f26ahr 226 19 ( ( -LRB- cord-028721-x6f26ahr 226 20 INSF-3 INSF-3 NNP cord-028721-x6f26ahr 226 21 ) ) -RRB- cord-028721-x6f26ahr 226 22 , , , cord-028721-x6f26ahr 226 23 a a DT cord-028721-x6f26ahr 226 24 member member NN cord-028721-x6f26ahr 226 25 of of IN cord-028721-x6f26ahr 226 26 the the DT cord-028721-x6f26ahr 226 27 relaxin relaxin NN cord-028721-x6f26ahr 226 28 - - HYPH cord-028721-x6f26ahr 226 29 insulin insulin NN cord-028721-x6f26ahr 226 30 family family NN cord-028721-x6f26ahr 226 31 that that WDT cord-028721-x6f26ahr 226 32 is be VBZ cord-028721-x6f26ahr 226 33 produced produce VBN cord-028721-x6f26ahr 226 34 by by IN cord-028721-x6f26ahr 226 35 fetal fetal JJ cord-028721-x6f26ahr 226 36 Leydig leydig NN cord-028721-x6f26ahr 226 37 cells cell NNS cord-028721-x6f26ahr 226 38 . . . cord-028721-x6f26ahr 227 1 This this DT cord-028721-x6f26ahr 227 2 peptide peptide NN cord-028721-x6f26ahr 227 3 stimulates stimulate VBZ cord-028721-x6f26ahr 227 4 gubernaculum gubernaculum NN cord-028721-x6f26ahr 227 5 cells cell NNS cord-028721-x6f26ahr 227 6 to to TO cord-028721-x6f26ahr 227 7 initiate initiate VB cord-028721-x6f26ahr 227 8 gubernaculum gubernaculum NN cord-028721-x6f26ahr 227 9 swelling swelling NN cord-028721-x6f26ahr 227 10 , , , cord-028721-x6f26ahr 227 11 a a DT cord-028721-x6f26ahr 227 12 necessary necessary JJ cord-028721-x6f26ahr 227 13 step step NN cord-028721-x6f26ahr 227 14 for for IN cord-028721-x6f26ahr 227 15 the the DT cord-028721-x6f26ahr 227 16 initiation initiation NN cord-028721-x6f26ahr 227 17 of of IN cord-028721-x6f26ahr 227 18 testicular testicular JJ cord-028721-x6f26ahr 227 19 descent descent NN cord-028721-x6f26ahr 227 20 . . . cord-028721-x6f26ahr 228 1 66 66 CD cord-028721-x6f26ahr 229 1 Mutations mutation NNS cord-028721-x6f26ahr 229 2 in in IN cord-028721-x6f26ahr 229 3 INSL-3 INSL-3 NNP cord-028721-x6f26ahr 229 4 gene gene NN cord-028721-x6f26ahr 229 5 or or CC cord-028721-x6f26ahr 229 6 its -PRON- PRP$ cord-028721-x6f26ahr 229 7 receptors receptor NNS cord-028721-x6f26ahr 229 8 LGRB-8 LGRB-8 VBN cord-028721-x6f26ahr 229 9 ( ( -LRB- cord-028721-x6f26ahr 229 10 leucine leucine NN cord-028721-x6f26ahr 229 11 - - HYPH cord-028721-x6f26ahr 229 12 rich rich JJ cord-028721-x6f26ahr 229 13 repeatcontaining repeatcontaine VBG cord-028721-x6f26ahr 229 14 G g NN cord-028721-x6f26ahr 229 15 protein protein NN cord-028721-x6f26ahr 229 16 - - HYPH cord-028721-x6f26ahr 229 17 coupled couple VBN cord-028721-x6f26ahr 229 18 receptor receptor NN cord-028721-x6f26ahr 229 19 8) 8) NN cord-028721-x6f26ahr 229 20 or or CC cord-028721-x6f26ahr 229 21 GREAT great JJ cord-028721-x6f26ahr 229 22 ( ( -LRB- cord-028721-x6f26ahr 229 23 G g NN cord-028721-x6f26ahr 229 24 protein protein NN cord-028721-x6f26ahr 229 25 - - HYPH cord-028721-x6f26ahr 229 26 coupled couple VBN cord-028721-x6f26ahr 229 27 receptor receptor NN cord-028721-x6f26ahr 229 28 affecting affect VBG cord-028721-x6f26ahr 229 29 testicular testicular JJ cord-028721-x6f26ahr 229 30 descent descent NN cord-028721-x6f26ahr 229 31 ) ) -RRB- cord-028721-x6f26ahr 229 32 interfere interfere VB cord-028721-x6f26ahr 229 33 with with IN cord-028721-x6f26ahr 229 34 transabdominal transabdominal JJ cord-028721-x6f26ahr 229 35 descent descent NN cord-028721-x6f26ahr 229 36 and and CC cord-028721-x6f26ahr 229 37 cause cause VB cord-028721-x6f26ahr 229 38 cryptorchidism cryptorchidism NNS cord-028721-x6f26ahr 229 39 . . . cord-028721-x6f26ahr 230 1 67 67 CD cord-028721-x6f26ahr 230 2 , , , cord-028721-x6f26ahr 230 3 68 68 CD cord-028721-x6f26ahr 230 4 AMH amh NN cord-028721-x6f26ahr 230 5 and and CC cord-028721-x6f26ahr 230 6 androgens androgen NNS cord-028721-x6f26ahr 230 7 are be VBP cord-028721-x6f26ahr 230 8 also also RB cord-028721-x6f26ahr 230 9 involved involve VBN cord-028721-x6f26ahr 230 10 in in IN cord-028721-x6f26ahr 230 11 the the DT cord-028721-x6f26ahr 230 12 gubernaculum gubernaculum NN cord-028721-x6f26ahr 230 13 swelling swell VBG cord-028721-x6f26ahr 230 14 reaction reaction NN cord-028721-x6f26ahr 230 15 ; ; : cord-028721-x6f26ahr 230 16 androgens androgen NNS cord-028721-x6f26ahr 230 17 also also RB cord-028721-x6f26ahr 230 18 facilitate facilitate VBP cord-028721-x6f26ahr 230 19 regression regression NN cord-028721-x6f26ahr 230 20 of of IN cord-028721-x6f26ahr 230 21 the the DT cord-028721-x6f26ahr 230 22 cranial cranial JJ cord-028721-x6f26ahr 230 23 suspensory suspensory NN cord-028721-x6f26ahr 230 24 ligament ligament NN cord-028721-x6f26ahr 230 25 . . . cord-028721-x6f26ahr 231 1 Uncertainty uncertainty NN cord-028721-x6f26ahr 231 2 exists exist VBZ cord-028721-x6f26ahr 231 3 regarding regard VBG cord-028721-x6f26ahr 231 4 the the DT cord-028721-x6f26ahr 231 5 mechanism mechanism NN cord-028721-x6f26ahr 231 6 of of IN cord-028721-x6f26ahr 231 7 inguinoscrotal inguinoscrotal JJ cord-028721-x6f26ahr 231 8 descent descent NN cord-028721-x6f26ahr 231 9 and and CC cord-028721-x6f26ahr 231 10 its -PRON- PRP$ cord-028721-x6f26ahr 231 11 hormonal hormonal JJ cord-028721-x6f26ahr 231 12 control control NN cord-028721-x6f26ahr 231 13 . . . cord-028721-x6f26ahr 232 1 Androgens androgen NNS cord-028721-x6f26ahr 232 2 and and CC cord-028721-x6f26ahr 232 3 the the DT cord-028721-x6f26ahr 232 4 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 232 5 nerve nerve NN cord-028721-x6f26ahr 232 6 are be VBP cord-028721-x6f26ahr 232 7 two two CD cord-028721-x6f26ahr 232 8 factors factor NNS cord-028721-x6f26ahr 232 9 strongly strongly RB cord-028721-x6f26ahr 232 10 implicated implicate VBN cord-028721-x6f26ahr 232 11 in in IN cord-028721-x6f26ahr 232 12 these these DT cord-028721-x6f26ahr 232 13 processes process NNS cord-028721-x6f26ahr 232 14 . . . cord-028721-x6f26ahr 233 1 The the DT cord-028721-x6f26ahr 233 2 role role NN cord-028721-x6f26ahr 233 3 of of IN cord-028721-x6f26ahr 233 4 androgens androgen NNS cord-028721-x6f26ahr 233 5 on on IN cord-028721-x6f26ahr 233 6 the the DT cord-028721-x6f26ahr 233 7 gubernaculum gubernaculum NN cord-028721-x6f26ahr 233 8 is be VBZ cord-028721-x6f26ahr 233 9 very very RB cord-028721-x6f26ahr 233 10 limited limited JJ cord-028721-x6f26ahr 233 11 , , , cord-028721-x6f26ahr 233 12 because because IN cord-028721-x6f26ahr 233 13 this this DT cord-028721-x6f26ahr 233 14 structure structure NN cord-028721-x6f26ahr 233 15 has have VBZ cord-028721-x6f26ahr 233 16 neither neither DT cord-028721-x6f26ahr 233 17 muscular muscular JJ cord-028721-x6f26ahr 233 18 cells cell NNS cord-028721-x6f26ahr 233 19 69 69 CD cord-028721-x6f26ahr 233 20 nor nor CC cord-028721-x6f26ahr 233 21 androgen androgen NN cord-028721-x6f26ahr 233 22 receptors receptor NNS cord-028721-x6f26ahr 233 23 at at IN cord-028721-x6f26ahr 233 24 the the DT cord-028721-x6f26ahr 233 25 time time NN cord-028721-x6f26ahr 233 26 of of IN cord-028721-x6f26ahr 233 27 testicular testicular JJ cord-028721-x6f26ahr 233 28 descent descent NN cord-028721-x6f26ahr 233 29 . . . cord-028721-x6f26ahr 234 1 Androgenic androgenic JJ cord-028721-x6f26ahr 234 2 effects effect NNS cord-028721-x6f26ahr 234 3 are be VBP cord-028721-x6f26ahr 234 4 explained explain VBN cord-028721-x6f26ahr 234 5 by by IN cord-028721-x6f26ahr 234 6 the the DT cord-028721-x6f26ahr 234 7 hypothesis hypothesis NN cord-028721-x6f26ahr 234 8 of of IN cord-028721-x6f26ahr 234 9 the the DT cord-028721-x6f26ahr 234 10 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 234 11 nerve nerve NN cord-028721-x6f26ahr 234 12 . . . cord-028721-x6f26ahr 235 1 70 70 CD cord-028721-x6f26ahr 235 2 Androgens androgen NNS cord-028721-x6f26ahr 235 3 appear appear VBP cord-028721-x6f26ahr 235 4 to to TO cord-028721-x6f26ahr 235 5 act act VB cord-028721-x6f26ahr 235 6 on on IN cord-028721-x6f26ahr 235 7 the the DT cord-028721-x6f26ahr 235 8 nucleus nucleus NN cord-028721-x6f26ahr 235 9 of of IN cord-028721-x6f26ahr 235 10 the the DT cord-028721-x6f26ahr 235 11 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 235 12 nerve nerve NN cord-028721-x6f26ahr 235 13 in in IN cord-028721-x6f26ahr 235 14 the the DT cord-028721-x6f26ahr 235 15 spinal spinal JJ cord-028721-x6f26ahr 235 16 cord cord NN cord-028721-x6f26ahr 235 17 rather rather RB cord-028721-x6f26ahr 235 18 than than IN cord-028721-x6f26ahr 235 19 directly directly RB cord-028721-x6f26ahr 235 20 on on IN cord-028721-x6f26ahr 235 21 the the DT cord-028721-x6f26ahr 235 22 gubernacula gubernacula NN cord-028721-x6f26ahr 235 23 , , , cord-028721-x6f26ahr 235 24 producing produce VBG cord-028721-x6f26ahr 235 25 masculinization masculinization NN cord-028721-x6f26ahr 235 26 of of IN cord-028721-x6f26ahr 235 27 the the DT cord-028721-x6f26ahr 235 28 neurons neuron NNS cord-028721-x6f26ahr 235 29 that that WDT cord-028721-x6f26ahr 235 30 form form VBP cord-028721-x6f26ahr 235 31 this this DT cord-028721-x6f26ahr 235 32 nucleus nucleus NN cord-028721-x6f26ahr 235 33 71 71 CD cord-028721-x6f26ahr 235 34 ( ( -LRB- cord-028721-x6f26ahr 235 35 these these DT cord-028721-x6f26ahr 235 36 neurons neuron NNS cord-028721-x6f26ahr 235 37 are be VBP cord-028721-x6f26ahr 235 38 much much RB cord-028721-x6f26ahr 235 39 more more RBR cord-028721-x6f26ahr 235 40 numerous numerous JJ cord-028721-x6f26ahr 235 41 in in IN cord-028721-x6f26ahr 235 42 males male NNS cord-028721-x6f26ahr 235 43 than than IN cord-028721-x6f26ahr 235 44 in in IN cord-028721-x6f26ahr 235 45 females female NNS cord-028721-x6f26ahr 235 46 ) ) -RRB- cord-028721-x6f26ahr 235 47 and and CC cord-028721-x6f26ahr 235 48 secreting secrete VBG cord-028721-x6f26ahr 235 49 great great JJ cord-028721-x6f26ahr 235 50 amounts amount NNS cord-028721-x6f26ahr 235 51 of of IN cord-028721-x6f26ahr 235 52 calcitonin calcitonin NN cord-028721-x6f26ahr 235 53 gene gene NN cord-028721-x6f26ahr 235 54 - - HYPH cord-028721-x6f26ahr 235 55 related relate VBN cord-028721-x6f26ahr 235 56 peptide peptide NN cord-028721-x6f26ahr 235 57 ( ( -LRB- cord-028721-x6f26ahr 235 58 CGRP CGRP NNP cord-028721-x6f26ahr 235 59 ) ) -RRB- cord-028721-x6f26ahr 235 60 . . . cord-028721-x6f26ahr 236 1 In in IN cord-028721-x6f26ahr 236 2 rats rat NNS cord-028721-x6f26ahr 236 3 , , , cord-028721-x6f26ahr 236 4 CGRP CGRP NNP cord-028721-x6f26ahr 236 5 causes cause VBZ cord-028721-x6f26ahr 236 6 rapid rapid JJ cord-028721-x6f26ahr 236 7 rhythmic rhythmic JJ cord-028721-x6f26ahr 236 8 contractions contraction NNS cord-028721-x6f26ahr 236 9 of of IN cord-028721-x6f26ahr 236 10 the the DT cord-028721-x6f26ahr 236 11 gubernaculum gubernaculum NN cord-028721-x6f26ahr 236 12 and and CC cord-028721-x6f26ahr 236 13 it -PRON- PRP cord-028721-x6f26ahr 236 14 has have VBZ cord-028721-x6f26ahr 236 15 been be VBN cord-028721-x6f26ahr 236 16 suggested suggest VBN cord-028721-x6f26ahr 236 17 that that IN cord-028721-x6f26ahr 236 18 the the DT cord-028721-x6f26ahr 236 19 gubernaculum gubernaculum NN cord-028721-x6f26ahr 236 20 might may MD cord-028721-x6f26ahr 236 21 have have VB cord-028721-x6f26ahr 236 22 embryonic embryonic JJ cord-028721-x6f26ahr 236 23 cardiac cardiac JJ cord-028721-x6f26ahr 236 24 muscle muscle NN cord-028721-x6f26ahr 236 25 cells cell NNS cord-028721-x6f26ahr 236 26 . . . cord-028721-x6f26ahr 237 1 However however RB cord-028721-x6f26ahr 237 2 , , , cord-028721-x6f26ahr 237 3 it -PRON- PRP cord-028721-x6f26ahr 237 4 is be VBZ cord-028721-x6f26ahr 237 5 also also RB cord-028721-x6f26ahr 237 6 possible possible JJ cord-028721-x6f26ahr 237 7 that that IN cord-028721-x6f26ahr 237 8 CGRP CGRP NNP cord-028721-x6f26ahr 237 9 acts act VBZ cord-028721-x6f26ahr 237 10 on on IN cord-028721-x6f26ahr 237 11 the the DT cord-028721-x6f26ahr 237 12 cremasteric cremasteric JJ cord-028721-x6f26ahr 237 13 muscle muscle NN cord-028721-x6f26ahr 237 14 that that WDT cord-028721-x6f26ahr 237 15 develops develop VBZ cord-028721-x6f26ahr 237 16 within within IN cord-028721-x6f26ahr 237 17 the the DT cord-028721-x6f26ahr 237 18 gubernaculum gubernaculum NN cord-028721-x6f26ahr 237 19 and and CC cord-028721-x6f26ahr 237 20 is be VBZ cord-028721-x6f26ahr 237 21 innervated innervate VBN cord-028721-x6f26ahr 237 22 by by IN cord-028721-x6f26ahr 237 23 the the DT cord-028721-x6f26ahr 237 24 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 237 25 nerve nerve NN cord-028721-x6f26ahr 237 26 . . . cord-028721-x6f26ahr 238 1 This this DT cord-028721-x6f26ahr 238 2 hypothesis hypothesis NN cord-028721-x6f26ahr 238 3 is be VBZ cord-028721-x6f26ahr 238 4 supported support VBN cord-028721-x6f26ahr 238 5 by by IN cord-028721-x6f26ahr 238 6 the the DT cord-028721-x6f26ahr 238 7 observation observation NN cord-028721-x6f26ahr 238 8 of of IN cord-028721-x6f26ahr 238 9 neurogenic neurogenic JJ cord-028721-x6f26ahr 238 10 atrophy atrophy NN cord-028721-x6f26ahr 238 11 of of IN cord-028721-x6f26ahr 238 12 this this DT cord-028721-x6f26ahr 238 13 muscle muscle NN cord-028721-x6f26ahr 238 14 in in IN cord-028721-x6f26ahr 238 15 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 238 16 patients patient NNS cord-028721-x6f26ahr 238 17 . . . cord-028721-x6f26ahr 239 1 72 72 CD cord-028721-x6f26ahr 239 2 Other other JJ cord-028721-x6f26ahr 239 3 factors factor NNS cord-028721-x6f26ahr 239 4 involved involve VBN cord-028721-x6f26ahr 239 5 in in IN cord-028721-x6f26ahr 239 6 testicular testicular JJ cord-028721-x6f26ahr 239 7 descent descent NN cord-028721-x6f26ahr 239 8 are be VBP cord-028721-x6f26ahr 239 9 estrogens estrogen NNS cord-028721-x6f26ahr 239 10 and and CC cord-028721-x6f26ahr 239 11 epidermal epidermal JJ cord-028721-x6f26ahr 239 12 growth growth NN cord-028721-x6f26ahr 239 13 factor factor NN cord-028721-x6f26ahr 239 14 ( ( -LRB- cord-028721-x6f26ahr 239 15 EGF EGF NNP cord-028721-x6f26ahr 239 16 ) ) -RRB- cord-028721-x6f26ahr 239 17 . . . cord-028721-x6f26ahr 240 1 During during IN cord-028721-x6f26ahr 240 2 the the DT cord-028721-x6f26ahr 240 3 fi fi NN cord-028721-x6f26ahr 240 4 rst rst NN cord-028721-x6f26ahr 240 5 trimester trimester NN cord-028721-x6f26ahr 240 6 of of IN cord-028721-x6f26ahr 240 7 gestation gestation NN cord-028721-x6f26ahr 240 8 , , , cord-028721-x6f26ahr 240 9 mothers mother NNS cord-028721-x6f26ahr 240 10 of of IN cord-028721-x6f26ahr 240 11 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 240 12 infants infant NNS cord-028721-x6f26ahr 240 13 have have VBP cord-028721-x6f26ahr 240 14 free free JJ cord-028721-x6f26ahr 240 15 estradiol estradiol NN cord-028721-x6f26ahr 240 16 serum serum NN cord-028721-x6f26ahr 240 17 concentrations concentration NNS cord-028721-x6f26ahr 240 18 that that WDT cord-028721-x6f26ahr 240 19 are be VBP cord-028721-x6f26ahr 240 20 signifi signifi NNP cord-028721-x6f26ahr 240 21 cantly cantly RB cord-028721-x6f26ahr 240 22 higher high JJR cord-028721-x6f26ahr 240 23 than than IN cord-028721-x6f26ahr 240 24 those those DT cord-028721-x6f26ahr 240 25 of of IN cord-028721-x6f26ahr 240 26 controls control NNS cord-028721-x6f26ahr 240 27 . . . cord-028721-x6f26ahr 241 1 73 73 CD cord-028721-x6f26ahr 241 2 Experimental experimental JJ cord-028721-x6f26ahr 241 3 studies study NNS cord-028721-x6f26ahr 241 4 have have VBP cord-028721-x6f26ahr 241 5 shown show VBN cord-028721-x6f26ahr 241 6 that that IN cord-028721-x6f26ahr 241 7 estradiol estradiol NN cord-028721-x6f26ahr 241 8 diminishes diminish VBZ cord-028721-x6f26ahr 241 9 gubernacular gubernacular JJ cord-028721-x6f26ahr 241 10 swelling swell VBG cord-028721-x6f26ahr 241 11 and and CC cord-028721-x6f26ahr 241 12 stabilizes stabilize VBZ cord-028721-x6f26ahr 241 13 müllerian müllerian JJ cord-028721-x6f26ahr 241 14 ducts duct NNS cord-028721-x6f26ahr 241 15 . . . cord-028721-x6f26ahr 242 1 It -PRON- PRP cord-028721-x6f26ahr 242 2 has have VBZ cord-028721-x6f26ahr 242 3 been be VBN cord-028721-x6f26ahr 242 4 proposed propose VBN cord-028721-x6f26ahr 242 5 that that IN cord-028721-x6f26ahr 242 6 estradiol estradiol NN cord-028721-x6f26ahr 242 7 inhibits inhibit VBZ cord-028721-x6f26ahr 242 8 the the DT cord-028721-x6f26ahr 242 9 cell cell NN cord-028721-x6f26ahr 242 10 proliferation proliferation NN cord-028721-x6f26ahr 242 11 that that WDT cord-028721-x6f26ahr 242 12 causes cause VBZ cord-028721-x6f26ahr 242 13 gubernaculum gubernaculum NN cord-028721-x6f26ahr 242 14 swelling swelling NN cord-028721-x6f26ahr 242 15 . . . cord-028721-x6f26ahr 243 1 74 74 CD cord-028721-x6f26ahr 243 2 , , , cord-028721-x6f26ahr 243 3 75 75 CD cord-028721-x6f26ahr 243 4 EGF EGF NNP cord-028721-x6f26ahr 243 5 may may MD cord-028721-x6f26ahr 243 6 facilitate facilitate VB cord-028721-x6f26ahr 243 7 testicular testicular JJ cord-028721-x6f26ahr 243 8 descent descent NN cord-028721-x6f26ahr 243 9 throughout throughout IN cord-028721-x6f26ahr 243 10 the the DT cord-028721-x6f26ahr 243 11 placental placental NN cord-028721-x6f26ahr 243 12 - - HYPH cord-028721-x6f26ahr 243 13 gonadal gonadal NN cord-028721-x6f26ahr 243 14 axis axis NN cord-028721-x6f26ahr 243 15 . . . cord-028721-x6f26ahr 244 1 Maternal maternal JJ cord-028721-x6f26ahr 244 2 EGF EGF NNP cord-028721-x6f26ahr 244 3 levels level NNS cord-028721-x6f26ahr 244 4 increase increase VBP cord-028721-x6f26ahr 244 5 just just RB cord-028721-x6f26ahr 244 6 before before IN cord-028721-x6f26ahr 244 7 fetal fetal JJ cord-028721-x6f26ahr 244 8 masculinization masculinization NN cord-028721-x6f26ahr 244 9 occurs occur VBZ cord-028721-x6f26ahr 244 10 . . . cord-028721-x6f26ahr 245 1 76 76 CD cord-028721-x6f26ahr 246 1 The the DT cord-028721-x6f26ahr 246 2 placenta placenta NN cord-028721-x6f26ahr 246 3 has have VBZ cord-028721-x6f26ahr 246 4 an an DT cord-028721-x6f26ahr 246 5 elevated elevated JJ cord-028721-x6f26ahr 246 6 concentration concentration NN cord-028721-x6f26ahr 246 7 of of IN cord-028721-x6f26ahr 246 8 EGF EGF NNP cord-028721-x6f26ahr 246 9 receptors receptor NNS cord-028721-x6f26ahr 246 10 , , , cord-028721-x6f26ahr 246 11 and and CC cord-028721-x6f26ahr 246 12 placental placental JJ cord-028721-x6f26ahr 246 13 stimulation stimulation NN cord-028721-x6f26ahr 246 14 by by IN cord-028721-x6f26ahr 246 15 EGF EGF NNP cord-028721-x6f26ahr 246 16 might may MD cord-028721-x6f26ahr 246 17 stimulate stimulate VB cord-028721-x6f26ahr 246 18 hCG hcg JJ cord-028721-x6f26ahr 246 19 production production NN cord-028721-x6f26ahr 246 20 , , , cord-028721-x6f26ahr 246 21 which which WDT cord-028721-x6f26ahr 246 22 may may MD cord-028721-x6f26ahr 246 23 also also RB cord-028721-x6f26ahr 246 24 stimulate stimulate VB cord-028721-x6f26ahr 246 25 fetal fetal JJ cord-028721-x6f26ahr 246 26 Leydig leydig NN cord-028721-x6f26ahr 246 27 cells cell NNS cord-028721-x6f26ahr 246 28 to to TO cord-028721-x6f26ahr 246 29 produce produce VB cord-028721-x6f26ahr 246 30 androgens androgen NNS cord-028721-x6f26ahr 246 31 ; ; : cord-028721-x6f26ahr 246 32 hypothetically hypothetically RB cord-028721-x6f26ahr 246 33 , , , cord-028721-x6f26ahr 246 34 these these DT cord-028721-x6f26ahr 246 35 and/or and/or CC cord-028721-x6f26ahr 246 36 other other JJ cord-028721-x6f26ahr 246 37 factors factor NNS cord-028721-x6f26ahr 246 38 may may MD cord-028721-x6f26ahr 246 39 determine determine VB cord-028721-x6f26ahr 246 40 testicular testicular JJ cord-028721-x6f26ahr 246 41 descent descent NN cord-028721-x6f26ahr 246 42 . . . cord-028721-x6f26ahr 247 1 After after IN cord-028721-x6f26ahr 247 2 birth birth NN cord-028721-x6f26ahr 247 3 , , , cord-028721-x6f26ahr 247 4 the the DT cord-028721-x6f26ahr 247 5 gubernaculum gubernaculum NN cord-028721-x6f26ahr 247 6 and and CC cord-028721-x6f26ahr 247 7 processus processus NNP cord-028721-x6f26ahr 247 8 vaginalis vaginalis NNP cord-028721-x6f26ahr 247 9 regress regress VBP cord-028721-x6f26ahr 247 10 . . . cord-028721-x6f26ahr 248 1 The the DT cord-028721-x6f26ahr 248 2 gubernaculum gubernaculum NN cord-028721-x6f26ahr 248 3 is be VBZ cord-028721-x6f26ahr 248 4 replaced replace VBN cord-028721-x6f26ahr 248 5 by by IN cord-028721-x6f26ahr 248 6 fi fi NNP cord-028721-x6f26ahr 248 7 brous brous JJ cord-028721-x6f26ahr 248 8 tissue tissue NN cord-028721-x6f26ahr 248 9 that that WDT cord-028721-x6f26ahr 248 10 forms form VBZ cord-028721-x6f26ahr 248 11 the the DT cord-028721-x6f26ahr 248 12 scrotal scrotal JJ cord-028721-x6f26ahr 248 13 ligament ligament NN cord-028721-x6f26ahr 248 14 . . . cord-028721-x6f26ahr 249 1 The the DT cord-028721-x6f26ahr 249 2 cephalic cephalic JJ cord-028721-x6f26ahr 249 3 segment segment NN cord-028721-x6f26ahr 249 4 of of IN cord-028721-x6f26ahr 249 5 the the DT cord-028721-x6f26ahr 249 6 processus processus NNP cord-028721-x6f26ahr 249 7 vaginalis vaginalis NNP cord-028721-x6f26ahr 249 8 atrophies atrophy VBZ cord-028721-x6f26ahr 249 9 after after IN cord-028721-x6f26ahr 249 10 testicular testicular JJ cord-028721-x6f26ahr 249 11 descent descent NN cord-028721-x6f26ahr 249 12 . . . cord-028721-x6f26ahr 250 1 An an DT cord-028721-x6f26ahr 250 2 exaggerated exaggerated JJ cord-028721-x6f26ahr 250 3 resorption resorption NN cord-028721-x6f26ahr 250 4 of of IN cord-028721-x6f26ahr 250 5 the the DT cord-028721-x6f26ahr 250 6 processus processus NNP cord-028721-x6f26ahr 250 7 vaginalis vaginalis NNP cord-028721-x6f26ahr 250 8 with with IN cord-028721-x6f26ahr 250 9 pulling pull VBG cord-028721-x6f26ahr 250 10 up up RP cord-028721-x6f26ahr 250 11 of of IN cord-028721-x6f26ahr 250 12 the the DT cord-028721-x6f26ahr 250 13 testis testis NN cord-028721-x6f26ahr 250 14 may may MD cord-028721-x6f26ahr 250 15 induce induce VB cord-028721-x6f26ahr 250 16 a a DT cord-028721-x6f26ahr 250 17 testis testis NN cord-028721-x6f26ahr 250 18 that that WDT cord-028721-x6f26ahr 250 19 had have VBD cord-028721-x6f26ahr 250 20 descended descend VBN cord-028721-x6f26ahr 250 21 normally normally RB cord-028721-x6f26ahr 250 22 to to TO cord-028721-x6f26ahr 250 23 ascend ascend VB cord-028721-x6f26ahr 250 24 , , , cord-028721-x6f26ahr 250 25 resulting result VBG cord-028721-x6f26ahr 250 26 in in IN cord-028721-x6f26ahr 250 27 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 250 28 . . . cord-028721-x6f26ahr 251 1 77 77 CD cord-028721-x6f26ahr 252 1 From from IN cord-028721-x6f26ahr 252 2 birth birth NN cord-028721-x6f26ahr 252 3 to to IN cord-028721-x6f26ahr 252 4 puberty puberty NN cord-028721-x6f26ahr 252 5 the the DT cord-028721-x6f26ahr 252 6 testis testis NN cord-028721-x6f26ahr 252 7 is be VBZ cord-028721-x6f26ahr 252 8 a a DT cord-028721-x6f26ahr 252 9 dynamic dynamic JJ cord-028721-x6f26ahr 252 10 structure structure NN cord-028721-x6f26ahr 252 11 , , , cord-028721-x6f26ahr 252 12 an an DT cord-028721-x6f26ahr 252 13 important important JJ cord-028721-x6f26ahr 252 14 consideration consideration NN cord-028721-x6f26ahr 252 15 in in IN cord-028721-x6f26ahr 252 16 interpreting interpret VBG cord-028721-x6f26ahr 252 17 biopsies biopsy NNS cord-028721-x6f26ahr 252 18 from from IN cord-028721-x6f26ahr 252 19 children child NNS cord-028721-x6f26ahr 252 20 . . . cord-028721-x6f26ahr 253 1 All all DT cord-028721-x6f26ahr 253 2 testicular testicular NN cord-028721-x6f26ahr 253 3 components component NNS cord-028721-x6f26ahr 253 4 undergo undergo VBP cord-028721-x6f26ahr 253 5 waves wave NNS cord-028721-x6f26ahr 253 6 of of IN cord-028721-x6f26ahr 253 7 proliferation proliferation NN cord-028721-x6f26ahr 253 8 and and CC cord-028721-x6f26ahr 253 9 differentiation differentiation NN cord-028721-x6f26ahr 253 10 prior prior RB cord-028721-x6f26ahr 253 11 to to IN cord-028721-x6f26ahr 253 12 puberty puberty NN cord-028721-x6f26ahr 253 13 . . . cord-028721-x6f26ahr 254 1 78 78 CD cord-028721-x6f26ahr 255 1 Three three CD cord-028721-x6f26ahr 255 2 waves wave NNS cord-028721-x6f26ahr 255 3 of of IN cord-028721-x6f26ahr 255 4 germ germ NN cord-028721-x6f26ahr 255 5 cell cell NN cord-028721-x6f26ahr 255 6 proliferation proliferation NN cord-028721-x6f26ahr 255 7 occur occur VBP cord-028721-x6f26ahr 255 8 : : : cord-028721-x6f26ahr 255 9 during during IN cord-028721-x6f26ahr 255 10 the the DT cord-028721-x6f26ahr 255 11 neonatal neonatal JJ cord-028721-x6f26ahr 255 12 period period NN cord-028721-x6f26ahr 255 13 , , , cord-028721-x6f26ahr 255 14 infancy infancy NN cord-028721-x6f26ahr 255 15 , , , cord-028721-x6f26ahr 255 16 and and CC cord-028721-x6f26ahr 255 17 puberty puberty NN cord-028721-x6f26ahr 255 18 . . . cord-028721-x6f26ahr 256 1 79 79 CD cord-028721-x6f26ahr 257 1 The the DT cord-028721-x6f26ahr 257 2 last last JJ cord-028721-x6f26ahr 257 3 gives give VBZ cord-028721-x6f26ahr 257 4 rise rise VBP cord-028721-x6f26ahr 257 5 to to TO cord-028721-x6f26ahr 257 6 complete complete VB cord-028721-x6f26ahr 257 7 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 257 8 . . . cord-028721-x6f26ahr 258 1 There there EX cord-028721-x6f26ahr 258 2 also also RB cord-028721-x6f26ahr 258 3 are be VBP cord-028721-x6f26ahr 258 4 three three CD cord-028721-x6f26ahr 258 5 waves wave NNS cord-028721-x6f26ahr 258 6 of of IN cord-028721-x6f26ahr 258 7 Leydig Leydig NNP cord-028721-x6f26ahr 258 8 cell cell NN cord-028721-x6f26ahr 258 9 proliferation proliferation NN cord-028721-x6f26ahr 258 10 ( ( -LRB- cord-028721-x6f26ahr 258 11 fetal fetal JJ cord-028721-x6f26ahr 258 12 , , , cord-028721-x6f26ahr 258 13 neonatal neonatal JJ cord-028721-x6f26ahr 258 14 , , , cord-028721-x6f26ahr 258 15 and and CC cord-028721-x6f26ahr 258 16 pubertal pubertal JJ cord-028721-x6f26ahr 258 17 ) ) -RRB- cord-028721-x6f26ahr 258 18 ; ; : cord-028721-x6f26ahr 258 19 the the DT cord-028721-x6f26ahr 258 20 last last JJ cord-028721-x6f26ahr 258 21 corresponds correspond VBZ cord-028721-x6f26ahr 258 22 to to IN cord-028721-x6f26ahr 258 23 the the DT cord-028721-x6f26ahr 258 24 pubertal pubertal JJ cord-028721-x6f26ahr 258 25 wave wave NN cord-028721-x6f26ahr 258 26 of of IN cord-028721-x6f26ahr 258 27 germ germ NN cord-028721-x6f26ahr 258 28 cell cell NN cord-028721-x6f26ahr 258 29 proliferation proliferation NN cord-028721-x6f26ahr 258 30 . . . cord-028721-x6f26ahr 259 1 The the DT cord-028721-x6f26ahr 259 2 testis testis NN cord-028721-x6f26ahr 259 3 at at IN cord-028721-x6f26ahr 259 4 birth birth NN cord-028721-x6f26ahr 260 1 The the DT cord-028721-x6f26ahr 260 2 newborn newborn JJ cord-028721-x6f26ahr 260 3 testis testis NN cord-028721-x6f26ahr 260 4 has have VBZ cord-028721-x6f26ahr 260 5 a a DT cord-028721-x6f26ahr 260 6 volume volume NN cord-028721-x6f26ahr 260 7 of of IN cord-028721-x6f26ahr 260 8 about about RB cord-028721-x6f26ahr 260 9 0.57 0.57 CD cord-028721-x6f26ahr 260 10 mL ml NN cord-028721-x6f26ahr 260 11 80 80 CD cord-028721-x6f26ahr 260 12 and and CC cord-028721-x6f26ahr 260 13 is be VBZ cord-028721-x6f26ahr 260 14 covered cover VBN cord-028721-x6f26ahr 260 15 by by IN cord-028721-x6f26ahr 260 16 a a DT cord-028721-x6f26ahr 260 17 thin thin JJ cord-028721-x6f26ahr 260 18 tunica tunica NNP cord-028721-x6f26ahr 260 19 albuginea albuginea NNP cord-028721-x6f26ahr 260 20 from from IN cord-028721-x6f26ahr 260 21 which which WDT cord-028721-x6f26ahr 261 1 the the DT cord-028721-x6f26ahr 261 2 intratesticular intratesticular NNP cord-028721-x6f26ahr 261 3 septa septa NNP cord-028721-x6f26ahr 261 4 arise arise VBP cord-028721-x6f26ahr 261 5 . . . cord-028721-x6f26ahr 262 1 These these DT cord-028721-x6f26ahr 262 2 divide divide VBP cord-028721-x6f26ahr 262 3 the the DT cord-028721-x6f26ahr 262 4 testis testis NN cord-028721-x6f26ahr 262 5 into into IN cord-028721-x6f26ahr 262 6 lobules lobule NNS cord-028721-x6f26ahr 262 7 containing contain VBG cord-028721-x6f26ahr 262 8 the the DT cord-028721-x6f26ahr 262 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 262 10 tubules tubule NNS cord-028721-x6f26ahr 262 11 and and CC cord-028721-x6f26ahr 262 12 testicular testicular NNP cord-028721-x6f26ahr 262 13 interstitium interstitium NN cord-028721-x6f26ahr 263 1 ( ( -LRB- cord-028721-x6f26ahr 263 2 Fig Fig NNP cord-028721-x6f26ahr 263 3 . . . cord-028721-x6f26ahr 263 4 12 12 CD cord-028721-x6f26ahr 263 5 - - SYM cord-028721-x6f26ahr 263 6 8 8 CD cord-028721-x6f26ahr 263 7 ) ) -RRB- cord-028721-x6f26ahr 263 8 . . . cord-028721-x6f26ahr 264 1 The the DT cord-028721-x6f26ahr 264 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 264 3 tubules tubule NNS cord-028721-x6f26ahr 264 4 measure measure VBP cord-028721-x6f26ahr 264 5 60 60 CD cord-028721-x6f26ahr 264 6 - - SYM cord-028721-x6f26ahr 264 7 65 65 CD cord-028721-x6f26ahr 264 8 µm µm NN cord-028721-x6f26ahr 264 9 in in IN cord-028721-x6f26ahr 264 10 diameter diameter NN cord-028721-x6f26ahr 264 11 , , , cord-028721-x6f26ahr 264 12 with with IN cord-028721-x6f26ahr 264 13 no no DT cord-028721-x6f26ahr 264 14 apparent apparent JJ cord-028721-x6f26ahr 264 15 lumina lumina NN cord-028721-x6f26ahr 264 16 , , , cord-028721-x6f26ahr 264 17 and and CC cord-028721-x6f26ahr 264 18 are be VBP cord-028721-x6f26ahr 264 19 fi fi NNP cord-028721-x6f26ahr 264 20 lled lle VBN cord-028721-x6f26ahr 264 21 with with IN cord-028721-x6f26ahr 264 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 264 23 cells cell NNS cord-028721-x6f26ahr 264 24 and and CC cord-028721-x6f26ahr 264 25 germ germ NN cord-028721-x6f26ahr 264 26 cells cell NNS cord-028721-x6f26ahr 264 27 . . . cord-028721-x6f26ahr 265 1 Sertoli sertoli JJ cord-028721-x6f26ahr 265 2 cells cell NNS cord-028721-x6f26ahr 265 3 are be VBP cord-028721-x6f26ahr 265 4 the the DT cord-028721-x6f26ahr 265 5 most most RBS cord-028721-x6f26ahr 265 6 abundant abundant JJ cord-028721-x6f26ahr 265 7 , , , cord-028721-x6f26ahr 265 8 with with IN cord-028721-x6f26ahr 265 9 26 26 CD cord-028721-x6f26ahr 265 10 - - SYM cord-028721-x6f26ahr 265 11 28 28 CD cord-028721-x6f26ahr 265 12 cells cell NNS cord-028721-x6f26ahr 265 13 per per IN cord-028721-x6f26ahr 265 14 tubular tubular JJ cord-028721-x6f26ahr 265 15 cross cross JJ cord-028721-x6f26ahr 265 16 - - NN cord-028721-x6f26ahr 265 17 section section NN cord-028721-x6f26ahr 265 18 ( ( -LRB- cord-028721-x6f26ahr 265 19 Fig Fig NNP cord-028721-x6f26ahr 265 20 . . . cord-028721-x6f26ahr 265 21 12 12 CD cord-028721-x6f26ahr 265 22 - - SYM cord-028721-x6f26ahr 265 23 9 9 CD cord-028721-x6f26ahr 265 24 ) ) -RRB- cord-028721-x6f26ahr 265 25 . . . cord-028721-x6f26ahr 266 1 81 81 CD cord-028721-x6f26ahr 267 1 They -PRON- PRP cord-028721-x6f26ahr 267 2 form form VBP cord-028721-x6f26ahr 267 3 a a DT cord-028721-x6f26ahr 267 4 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 267 5 ed ed NN cord-028721-x6f26ahr 267 6 cellular cellular JJ cord-028721-x6f26ahr 267 7 layer layer NN cord-028721-x6f26ahr 267 8 and and CC cord-028721-x6f26ahr 267 9 have have VBP cord-028721-x6f26ahr 267 10 elongated elongate VBN cord-028721-x6f26ahr 267 11 to to IN cord-028721-x6f26ahr 267 12 oval oval JJ cord-028721-x6f26ahr 267 13 nuclei nucleus NNS cord-028721-x6f26ahr 267 14 with with IN cord-028721-x6f26ahr 267 15 darker dark JJR cord-028721-x6f26ahr 267 16 chromatin chromatin NN cord-028721-x6f26ahr 267 17 than than IN cord-028721-x6f26ahr 267 18 that that DT cord-028721-x6f26ahr 267 19 of of IN cord-028721-x6f26ahr 267 20 mature mature JJ cord-028721-x6f26ahr 267 21 Sertoli sertoli JJ cord-028721-x6f26ahr 267 22 cells cell NNS cord-028721-x6f26ahr 267 23 , , , cord-028721-x6f26ahr 267 24 as as RB cord-028721-x6f26ahr 267 25 well well RB cord-028721-x6f26ahr 267 26 as as IN cord-028721-x6f26ahr 267 27 one one CD cord-028721-x6f26ahr 267 28 or or CC cord-028721-x6f26ahr 267 29 two two CD cord-028721-x6f26ahr 267 30 small small JJ cord-028721-x6f26ahr 267 31 peripheral peripheral JJ cord-028721-x6f26ahr 267 32 nucleoli nucleolus NNS cord-028721-x6f26ahr 267 33 . . . cord-028721-x6f26ahr 268 1 The the DT cord-028721-x6f26ahr 268 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 268 3 contains contain VBZ cord-028721-x6f26ahr 268 4 abundant abundant JJ cord-028721-x6f26ahr 268 5 rough rough JJ cord-028721-x6f26ahr 268 6 endoplasmic endoplasmic NN cord-028721-x6f26ahr 268 7 reticulum reticulum NN cord-028721-x6f26ahr 268 8 , , , cord-028721-x6f26ahr 268 9 several several JJ cord-028721-x6f26ahr 268 10 Golgi Golgi NNP cord-028721-x6f26ahr 268 11 complexes complex NNS cord-028721-x6f26ahr 268 12 and and CC cord-028721-x6f26ahr 268 13 numerous numerous JJ cord-028721-x6f26ahr 268 14 vimentin vimentin NNS cord-028721-x6f26ahr 268 15 fi fi NN cord-028721-x6f26ahr 268 16 laments lament NNS cord-028721-x6f26ahr 268 17 , , , cord-028721-x6f26ahr 268 18 and and CC cord-028721-x6f26ahr 268 19 expresses express VBZ cord-028721-x6f26ahr 268 20 inhibin inhibin NNP cord-028721-x6f26ahr 268 21 B B NNP cord-028721-x6f26ahr 268 22 ( ( -LRB- cord-028721-x6f26ahr 268 23 Fig Fig NNP cord-028721-x6f26ahr 268 24 . . . cord-028721-x6f26ahr 268 25 12 12 CD cord-028721-x6f26ahr 268 26 - - SYM cord-028721-x6f26ahr 268 27 10 10 CD cord-028721-x6f26ahr 268 28 ) ) -RRB- cord-028721-x6f26ahr 268 29 . . . cord-028721-x6f26ahr 269 1 No no DT cord-028721-x6f26ahr 269 2 specialized specialized JJ cord-028721-x6f26ahr 269 3 intercellular intercellular JJ cord-028721-x6f26ahr 269 4 junctions junction NNS cord-028721-x6f26ahr 269 5 appear appear VBP cord-028721-x6f26ahr 269 6 between between IN cord-028721-x6f26ahr 269 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 269 8 cells cell NNS cord-028721-x6f26ahr 269 9 , , , cord-028721-x6f26ahr 269 10 but but CC cord-028721-x6f26ahr 269 11 desmosome desmosome NN cord-028721-x6f26ahr 269 12 - - HYPH cord-028721-x6f26ahr 269 13 like like JJ cord-028721-x6f26ahr 269 14 junctions junction NNS cord-028721-x6f26ahr 269 15 are be VBP cord-028721-x6f26ahr 269 16 present present JJ cord-028721-x6f26ahr 269 17 between between IN cord-028721-x6f26ahr 269 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 269 19 cells cell NNS cord-028721-x6f26ahr 269 20 and and CC cord-028721-x6f26ahr 269 21 germ germ NN cord-028721-x6f26ahr 269 22 cells cell NNS cord-028721-x6f26ahr 269 23 . . . cord-028721-x6f26ahr 270 1 82 82 CD cord-028721-x6f26ahr 271 1 Two two CD cord-028721-x6f26ahr 271 2 types type NNS cord-028721-x6f26ahr 271 3 of of IN cord-028721-x6f26ahr 271 4 germ germ NN cord-028721-x6f26ahr 271 5 cell cell NN cord-028721-x6f26ahr 271 6 are be VBP cord-028721-x6f26ahr 271 7 present present JJ cord-028721-x6f26ahr 271 8 at at IN cord-028721-x6f26ahr 271 9 birth birth NN cord-028721-x6f26ahr 271 10 : : : cord-028721-x6f26ahr 271 11 gonocytes gonocytes NNP cord-028721-x6f26ahr 271 12 and and CC cord-028721-x6f26ahr 271 13 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 271 14 . . . cord-028721-x6f26ahr 272 1 Gonocytes Gonocytes NNP cord-028721-x6f26ahr 272 2 are be VBP cord-028721-x6f26ahr 272 3 usually usually RB cord-028721-x6f26ahr 272 4 located locate VBN cord-028721-x6f26ahr 272 5 near near IN cord-028721-x6f26ahr 272 6 the the DT cord-028721-x6f26ahr 272 7 center center NN cord-028721-x6f26ahr 272 8 of of IN cord-028721-x6f26ahr 272 9 the the DT cord-028721-x6f26ahr 272 10 tubules tubule NNS cord-028721-x6f26ahr 272 11 , , , cord-028721-x6f26ahr 272 12 with with IN cord-028721-x6f26ahr 272 13 voluminous voluminous JJ cord-028721-x6f26ahr 272 14 nuclei nucleus NNS cord-028721-x6f26ahr 272 15 and and CC cord-028721-x6f26ahr 272 16 large large JJ cord-028721-x6f26ahr 272 17 central central JJ cord-028721-x6f26ahr 272 18 nucleoli nucleoli NN cord-028721-x6f26ahr 272 19 . . . cord-028721-x6f26ahr 273 1 82 82 CD cord-028721-x6f26ahr 273 2 Gonocyte Gonocyte NNP cord-028721-x6f26ahr 273 3 migration migration NN cord-028721-x6f26ahr 273 4 is be VBZ cord-028721-x6f26ahr 273 5 probably probably RB cord-028721-x6f26ahr 273 6 facilitated facilitate VBN cord-028721-x6f26ahr 273 7 by by IN cord-028721-x6f26ahr 273 8 cell cell NN cord-028721-x6f26ahr 273 9 adhesion adhesion NN cord-028721-x6f26ahr 273 10 molecules molecule NNS cord-028721-x6f26ahr 273 11 such such JJ cord-028721-x6f26ahr 273 12 as as IN cord-028721-x6f26ahr 273 13 P p NN cord-028721-x6f26ahr 273 14 cadherin cadherin NN cord-028721-x6f26ahr 273 15 , , , cord-028721-x6f26ahr 273 16 which which WDT cord-028721-x6f26ahr 273 17 is be VBZ cord-028721-x6f26ahr 273 18 expressed express VBN cord-028721-x6f26ahr 273 19 by by IN cord-028721-x6f26ahr 273 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 273 21 cells cell NNS cord-028721-x6f26ahr 273 22 of of IN cord-028721-x6f26ahr 273 23 immature immature JJ cord-028721-x6f26ahr 273 24 testes testis NNS cord-028721-x6f26ahr 273 25 . . . cord-028721-x6f26ahr 274 1 83 83 CD cord-028721-x6f26ahr 275 1 Spermatogonia Spermatogonia NNP cord-028721-x6f26ahr 275 2 are be VBP cord-028721-x6f26ahr 275 3 mainly mainly RB cord-028721-x6f26ahr 275 4 located locate VBN cord-028721-x6f26ahr 275 5 on on IN cord-028721-x6f26ahr 275 6 the the DT cord-028721-x6f26ahr 275 7 basal basal NN cord-028721-x6f26ahr 275 8 lamina lamina NN cord-028721-x6f26ahr 275 9 , , , cord-028721-x6f26ahr 275 10 and and CC cord-028721-x6f26ahr 275 11 possess possess VB cord-028721-x6f26ahr 275 12 smaller small JJR cord-028721-x6f26ahr 275 13 nuclei nucleus NNS cord-028721-x6f26ahr 275 14 and and CC cord-028721-x6f26ahr 275 15 less less RBR cord-028721-x6f26ahr 275 16 cytoplasm cytoplasm JJ cord-028721-x6f26ahr 275 17 than than IN cord-028721-x6f26ahr 275 18 gonocytes gonocyte NNS cord-028721-x6f26ahr 275 19 ; ; : cord-028721-x6f26ahr 275 20 the the DT cord-028721-x6f26ahr 275 21 nucleoli nucleoli NNP cord-028721-x6f26ahr 275 22 are be VBP cord-028721-x6f26ahr 275 23 peripheral peripheral JJ cord-028721-x6f26ahr 275 24 and and CC cord-028721-x6f26ahr 275 25 very very RB cord-028721-x6f26ahr 275 26 small small JJ cord-028721-x6f26ahr 275 27 . . . cord-028721-x6f26ahr 276 1 At at IN cord-028721-x6f26ahr 276 2 birth birth NN cord-028721-x6f26ahr 276 3 , , , cord-028721-x6f26ahr 276 4 most most JJS cord-028721-x6f26ahr 276 5 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 276 6 correspond correspond VBP cord-028721-x6f26ahr 276 7 to to IN cord-028721-x6f26ahr 276 8 the the DT cord-028721-x6f26ahr 276 9 adult adult NN cord-028721-x6f26ahr 276 10 type type NN cord-028721-x6f26ahr 276 11 A a NN cord-028721-x6f26ahr 276 12 ( ( -LRB- cord-028721-x6f26ahr 276 13 see see VB cord-028721-x6f26ahr 276 14 discussion discussion NN cord-028721-x6f26ahr 276 15 on on IN cord-028721-x6f26ahr 276 16 the the DT cord-028721-x6f26ahr 276 17 adult adult NN cord-028721-x6f26ahr 276 18 testis testis NN cord-028721-x6f26ahr 276 19 below below RB cord-028721-x6f26ahr 276 20 ) ) -RRB- cord-028721-x6f26ahr 277 1 ( ( -LRB- cord-028721-x6f26ahr 277 2 Fig Fig NNP cord-028721-x6f26ahr 277 3 . . . cord-028721-x6f26ahr 277 4 12 12 CD cord-028721-x6f26ahr 277 5 - - SYM cord-028721-x6f26ahr 277 6 11 11 CD cord-028721-x6f26ahr 277 7 ) ) -RRB- cord-028721-x6f26ahr 277 8 . . . cord-028721-x6f26ahr 278 1 The the DT cord-028721-x6f26ahr 278 2 testicular testicular JJ cord-028721-x6f26ahr 278 3 interstitium interstitium NN cord-028721-x6f26ahr 278 4 contains contain VBZ cord-028721-x6f26ahr 278 5 fetal fetal JJ cord-028721-x6f26ahr 278 6 Leydig Leydig NNP cord-028721-x6f26ahr 278 7 cells cell NNS cord-028721-x6f26ahr 278 8 that that WDT cord-028721-x6f26ahr 278 9 resemble resemble VBP cord-028721-x6f26ahr 278 10 adult adult NN cord-028721-x6f26ahr 278 11 Leydig Leydig NNP cord-028721-x6f26ahr 278 12 cells cell NNS cord-028721-x6f26ahr 278 13 but but CC cord-028721-x6f26ahr 278 14 lack lack VBP cord-028721-x6f26ahr 278 15 Reinke Reinke NNP cord-028721-x6f26ahr 278 16 's 's POS cord-028721-x6f26ahr 278 17 crystalloids crystalloid NNS cord-028721-x6f26ahr 278 18 ( ( -LRB- cord-028721-x6f26ahr 278 19 Fig Fig NNP cord-028721-x6f26ahr 278 20 . . . cord-028721-x6f26ahr 278 21 12 12 CD cord-028721-x6f26ahr 278 22 - - SYM cord-028721-x6f26ahr 278 23 12 12 CD cord-028721-x6f26ahr 278 24 ) ) -RRB- cord-028721-x6f26ahr 278 25 . . . cord-028721-x6f26ahr 279 1 84 84 CD cord-028721-x6f26ahr 279 2 , , , cord-028721-x6f26ahr 279 3 85 85 CD cord-028721-x6f26ahr 279 4 Additionally additionally RB cord-028721-x6f26ahr 279 5 , , , cord-028721-x6f26ahr 279 6 mast mast NN cord-028721-x6f26ahr 279 7 cells cell NNS cord-028721-x6f26ahr 279 8 , , , cord-028721-x6f26ahr 279 9 macrophages macrophage NNS cord-028721-x6f26ahr 279 10 , , , cord-028721-x6f26ahr 279 11 and and CC cord-028721-x6f26ahr 279 12 hematopoietic hematopoietic JJ cord-028721-x6f26ahr 279 13 cell cell NN cord-028721-x6f26ahr 279 14 are be VBP cord-028721-x6f26ahr 279 15 present present JJ cord-028721-x6f26ahr 279 16 . . . cord-028721-x6f26ahr 280 1 86 86 CD cord-028721-x6f26ahr 281 1 The the DT cord-028721-x6f26ahr 281 2 fi fi NN cord-028721-x6f26ahr 281 3 rst rst NN cord-028721-x6f26ahr 281 4 wave wave NN cord-028721-x6f26ahr 281 5 of of IN cord-028721-x6f26ahr 281 6 testicular testicular JJ cord-028721-x6f26ahr 281 7 development development NN cord-028721-x6f26ahr 281 8 occurs occur VBZ cord-028721-x6f26ahr 281 9 during during IN cord-028721-x6f26ahr 281 10 the the DT cord-028721-x6f26ahr 281 11 neonatal neonatal JJ cord-028721-x6f26ahr 281 12 period period NN cord-028721-x6f26ahr 281 13 and and CC cord-028721-x6f26ahr 281 14 involves involve VBZ cord-028721-x6f26ahr 281 15 germ germ NN cord-028721-x6f26ahr 281 16 cells cell NNS cord-028721-x6f26ahr 281 17 and and CC cord-028721-x6f26ahr 281 18 Leydig leydig NN cord-028721-x6f26ahr 281 19 cells cell NNS cord-028721-x6f26ahr 281 20 . . . cord-028721-x6f26ahr 282 1 These these DT cord-028721-x6f26ahr 282 2 changes change NNS cord-028721-x6f26ahr 282 3 are be VBP cord-028721-x6f26ahr 282 4 caused cause VBN cord-028721-x6f26ahr 282 5 by by IN cord-028721-x6f26ahr 282 6 a a DT cord-028721-x6f26ahr 282 7 signifi signifi NN cord-028721-x6f26ahr 282 8 ca can MD cord-028721-x6f26ahr 282 9 nt not RB cord-028721-x6f26ahr 282 10 increase increase VB cord-028721-x6f26ahr 282 11 in in IN cord-028721-x6f26ahr 282 12 secretion secretion NN cord-028721-x6f26ahr 282 13 of of IN cord-028721-x6f26ahr 282 14 both both CC cord-028721-x6f26ahr 282 15 FSH fsh NN cord-028721-x6f26ahr 282 16 and and CC cord-028721-x6f26ahr 282 17 LH LH NNP cord-028721-x6f26ahr 282 18 during during IN cord-028721-x6f26ahr 282 19 the the DT cord-028721-x6f26ahr 282 20 third third JJ cord-028721-x6f26ahr 282 21 postnatal postnatal JJ cord-028721-x6f26ahr 282 22 month month NN cord-028721-x6f26ahr 282 23 . . . cord-028721-x6f26ahr 283 1 87 87 CD cord-028721-x6f26ahr 283 2 - - SYM cord-028721-x6f26ahr 283 3 89 89 CD cord-028721-x6f26ahr 283 4 Testicular Testicular NNP cord-028721-x6f26ahr 283 5 weight weight NN cord-028721-x6f26ahr 283 6 and and CC cord-028721-x6f26ahr 283 7 volume volume NN cord-028721-x6f26ahr 283 8 increase increase NN cord-028721-x6f26ahr 283 9 . . . cord-028721-x6f26ahr 284 1 LH LH NNP cord-028721-x6f26ahr 284 2 stimulates stimulate VBZ cord-028721-x6f26ahr 284 3 the the DT cord-028721-x6f26ahr 284 4 Leydig Leydig NNP cord-028721-x6f26ahr 284 5 cells cell NNS cord-028721-x6f26ahr 284 6 to to TO cord-028721-x6f26ahr 284 7 produce produce VB cord-028721-x6f26ahr 284 8 testosterone testosterone NN cord-028721-x6f26ahr 284 9 , , , cord-028721-x6f26ahr 284 10 90,91 90,91 CD cord-028721-x6f26ahr 284 11 which which WDT cord-028721-x6f26ahr 284 12 stimulates stimulate VBZ cord-028721-x6f26ahr 284 13 the the DT cord-028721-x6f26ahr 284 14 transformation transformation NN cord-028721-x6f26ahr 284 15 of of IN cord-028721-x6f26ahr 284 16 gonocytes gonocyte NNS cord-028721-x6f26ahr 284 17 to to IN cord-028721-x6f26ahr 284 18 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 284 19 of of IN cord-028721-x6f26ahr 284 20 the the DT cord-028721-x6f26ahr 284 21 Ad ad NN cord-028721-x6f26ahr 284 22 type type NN cord-028721-x6f26ahr 285 1 ( ( -LRB- cord-028721-x6f26ahr 285 2 Fig Fig NNP cord-028721-x6f26ahr 285 3 . . . cord-028721-x6f26ahr 285 4 12 12 CD cord-028721-x6f26ahr 285 5 - - SYM cord-028721-x6f26ahr 285 6 13 13 CD cord-028721-x6f26ahr 285 7 ) ) -RRB- cord-028721-x6f26ahr 285 8 . . . cord-028721-x6f26ahr 286 1 Afterwards afterwards RB cord-028721-x6f26ahr 286 2 , , , cord-028721-x6f26ahr 286 3 some some DT cord-028721-x6f26ahr 286 4 of of IN cord-028721-x6f26ahr 286 5 these these DT cord-028721-x6f26ahr 287 1 In in IN cord-028721-x6f26ahr 287 2 some some DT cord-028721-x6f26ahr 287 3 normal normal JJ cord-028721-x6f26ahr 287 4 testes testis NNS cord-028721-x6f26ahr 287 5 at at IN cord-028721-x6f26ahr 287 6 this this DT cord-028721-x6f26ahr 287 7 age age NN cord-028721-x6f26ahr 287 8 , , , cord-028721-x6f26ahr 287 9 meiotic meiotic JJ cord-028721-x6f26ahr 287 10 primary primary JJ cord-028721-x6f26ahr 287 11 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 287 12 and and CC cord-028721-x6f26ahr 287 13 round round JJ cord-028721-x6f26ahr 287 14 spermatids spermatid NNS cord-028721-x6f26ahr 287 15 are be VBP cord-028721-x6f26ahr 287 16 observed observe VBN cord-028721-x6f26ahr 288 1 ( ( -LRB- cord-028721-x6f26ahr 288 2 Fig Fig NNP cord-028721-x6f26ahr 288 3 . . . cord-028721-x6f26ahr 288 4 12 12 CD cord-028721-x6f26ahr 288 5 - - SYM cord-028721-x6f26ahr 288 6 15 15 CD cord-028721-x6f26ahr 288 7 ) ) -RRB- cord-028721-x6f26ahr 288 8 . . . cord-028721-x6f26ahr 289 1 This this DT cord-028721-x6f26ahr 289 2 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 289 3 attempt attempt NN cord-028721-x6f26ahr 289 4 fails fail VBZ cord-028721-x6f26ahr 289 5 and and CC cord-028721-x6f26ahr 289 6 many many JJ cord-028721-x6f26ahr 289 7 degenerate degenerate JJ cord-028721-x6f26ahr 289 8 germ germ NN cord-028721-x6f26ahr 289 9 cells cell NNS cord-028721-x6f26ahr 289 10 may may MD cord-028721-x6f26ahr 289 11 be be VB cord-028721-x6f26ahr 289 12 present present JJ cord-028721-x6f26ahr 289 13 . . . cord-028721-x6f26ahr 290 1 94 94 CD cord-028721-x6f26ahr 290 2 , , , cord-028721-x6f26ahr 290 3 95 95 CD cord-028721-x6f26ahr 291 1 The the DT cord-028721-x6f26ahr 291 2 testis testis NN cord-028721-x6f26ahr 291 3 continues continue VBZ cord-028721-x6f26ahr 291 4 to to TO cord-028721-x6f26ahr 291 5 produce produce VB cord-028721-x6f26ahr 291 6 AMH AMH NNP cord-028721-x6f26ahr 291 7 ( ( -LRB- cord-028721-x6f26ahr 291 8 by by IN cord-028721-x6f26ahr 291 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 291 10 cells cell NNS cord-028721-x6f26ahr 291 11 ) ) -RRB- cord-028721-x6f26ahr 292 1 96 96 CD cord-028721-x6f26ahr 292 2 and and CC cord-028721-x6f26ahr 292 3 inhibin inhibin NNP cord-028721-x6f26ahr 292 4 B. B. NNP cord-028721-x6f26ahr 292 5 97 97 CD cord-028721-x6f26ahr 292 6 AMH AMH NNP cord-028721-x6f26ahr 292 7 modulates modulate VBZ cord-028721-x6f26ahr 292 8 the the DT cord-028721-x6f26ahr 292 9 number number NN cord-028721-x6f26ahr 292 10 and and CC cord-028721-x6f26ahr 292 11 function function NN cord-028721-x6f26ahr 292 12 of of IN cord-028721-x6f26ahr 292 13 Leydig Leydig NNP cord-028721-x6f26ahr 292 14 cells cell NNS cord-028721-x6f26ahr 292 15 by by IN cord-028721-x6f26ahr 292 16 regulating regulate VBG cord-028721-x6f26ahr 292 17 differentiation differentiation NN cord-028721-x6f26ahr 292 18 of of IN cord-028721-x6f26ahr 292 19 their -PRON- PRP$ cord-028721-x6f26ahr 292 20 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 292 21 precursors precursor NNS cord-028721-x6f26ahr 292 22 and and CC cord-028721-x6f26ahr 292 23 the the DT cord-028721-x6f26ahr 292 24 expression expression NN cord-028721-x6f26ahr 292 25 of of IN cord-028721-x6f26ahr 292 26 steroidogenic steroidogenic JJ cord-028721-x6f26ahr 292 27 enzymes enzyme NNS cord-028721-x6f26ahr 292 28 . . . cord-028721-x6f26ahr 293 1 98 98 CD cord-028721-x6f26ahr 294 1 Inhibin Inhibin NNP cord-028721-x6f26ahr 294 2 B B NNP cord-028721-x6f26ahr 294 3 plays play VBZ cord-028721-x6f26ahr 294 4 a a DT cord-028721-x6f26ahr 294 5 role role NN cord-028721-x6f26ahr 294 6 in in IN cord-028721-x6f26ahr 294 7 FSH fsh NN cord-028721-x6f26ahr 294 8 inactivation inactivation NN cord-028721-x6f26ahr 294 9 during during IN cord-028721-x6f26ahr 294 10 infancy infancy NN cord-028721-x6f26ahr 294 11 . . . cord-028721-x6f26ahr 295 1 The the DT cord-028721-x6f26ahr 295 2 cause cause NN cord-028721-x6f26ahr 295 3 of of IN cord-028721-x6f26ahr 295 4 this this DT cord-028721-x6f26ahr 295 5 second second JJ cord-028721-x6f26ahr 295 6 wave wave NN cord-028721-x6f26ahr 295 7 of of IN cord-028721-x6f26ahr 295 8 germ germ NN cord-028721-x6f26ahr 295 9 cell cell NN cord-028721-x6f26ahr 295 10 proliferation proliferation NN cord-028721-x6f26ahr 295 11 is be VBZ cord-028721-x6f26ahr 295 12 unknown unknown JJ cord-028721-x6f26ahr 295 13 ; ; : cord-028721-x6f26ahr 295 14 there there EX cord-028721-x6f26ahr 295 15 is be VBZ cord-028721-x6f26ahr 295 16 no no DT cord-028721-x6f26ahr 295 17 elevation elevation NN cord-028721-x6f26ahr 295 18 of of IN cord-028721-x6f26ahr 295 19 FSH FSH NNP cord-028721-x6f26ahr 295 20 or or CC cord-028721-x6f26ahr 295 21 LH LH NNP cord-028721-x6f26ahr 295 22 serum serum NN cord-028721-x6f26ahr 295 23 concentrations concentration NNS cord-028721-x6f26ahr 295 24 between between IN cord-028721-x6f26ahr 295 25 6 6 CD cord-028721-x6f26ahr 295 26 months month NNS cord-028721-x6f26ahr 295 27 and and CC cord-028721-x6f26ahr 295 28 10 10 CD cord-028721-x6f26ahr 295 29 years year NNS cord-028721-x6f26ahr 295 30 of of IN cord-028721-x6f26ahr 295 31 life life NN cord-028721-x6f26ahr 295 32 . . . cord-028721-x6f26ahr 296 1 After after IN cord-028721-x6f26ahr 296 2 the the DT cord-028721-x6f26ahr 296 3 sixth sixth JJ cord-028721-x6f26ahr 296 4 year year NN cord-028721-x6f26ahr 296 5 , , , cord-028721-x6f26ahr 296 6 there there EX cord-028721-x6f26ahr 296 7 is be VBZ cord-028721-x6f26ahr 296 8 a a DT cord-028721-x6f26ahr 296 9 slight slight JJ cord-028721-x6f26ahr 296 10 increase increase NN cord-028721-x6f26ahr 296 11 in in IN cord-028721-x6f26ahr 296 12 adrenal adrenal JJ cord-028721-x6f26ahr 296 13 androgens androgen NNS cord-028721-x6f26ahr 296 14 , , , cord-028721-x6f26ahr 296 15 but but CC cord-028721-x6f26ahr 296 16 testicular testicular JJ cord-028721-x6f26ahr 296 17 testosterone testosterone NN cord-028721-x6f26ahr 296 18 levels level NNS cord-028721-x6f26ahr 296 19 increase increase VBP cord-028721-x6f26ahr 296 20 only only RB cord-028721-x6f26ahr 296 21 after after IN cord-028721-x6f26ahr 296 22 the the DT cord-028721-x6f26ahr 296 23 10th 10th JJ cord-028721-x6f26ahr 296 24 year year NN cord-028721-x6f26ahr 296 25 . . . cord-028721-x6f26ahr 297 1 99 99 CD cord-028721-x6f26ahr 297 2 , , , cord-028721-x6f26ahr 297 3 100 100 CD cord-028721-x6f26ahr 297 4 By by IN cord-028721-x6f26ahr 297 5 the the DT cord-028721-x6f26ahr 297 6 third third JJ cord-028721-x6f26ahr 297 7 year year NN cord-028721-x6f26ahr 297 8 , , , cord-028721-x6f26ahr 297 9 most most JJS cord-028721-x6f26ahr 297 10 Leydig leydig NN cord-028721-x6f26ahr 297 11 cells cell NNS cord-028721-x6f26ahr 297 12 have have VBP cord-028721-x6f26ahr 297 13 degenerated degenerate VBN cord-028721-x6f26ahr 297 14 : : : cord-028721-x6f26ahr 297 15 from from IN cord-028721-x6f26ahr 297 16 a a DT cord-028721-x6f26ahr 297 17 peak peak NN cord-028721-x6f26ahr 297 18 of of IN cord-028721-x6f26ahr 297 19 about about IN cord-028721-x6f26ahr 297 20 18 18 CD cord-028721-x6f26ahr 297 21 million million CD cord-028721-x6f26ahr 297 22 at at IN cord-028721-x6f26ahr 297 23 birth birth NN cord-028721-x6f26ahr 297 24 , , , cord-028721-x6f26ahr 297 25 only only RB cord-028721-x6f26ahr 297 26 60 60 CD cord-028721-x6f26ahr 297 27 000 000 CD cord-028721-x6f26ahr 297 28 remain remain VBP cord-028721-x6f26ahr 297 29 by by IN cord-028721-x6f26ahr 297 30 the the DT cord-028721-x6f26ahr 297 31 age age NN cord-028721-x6f26ahr 297 32 of of IN cord-028721-x6f26ahr 297 33 6 6 CD cord-028721-x6f26ahr 297 34 years year NNS cord-028721-x6f26ahr 297 35 . . . cord-028721-x6f26ahr 298 1 At at IN cord-028721-x6f26ahr 298 2 this this DT cord-028721-x6f26ahr 298 3 age age NN cord-028721-x6f26ahr 298 4 , , , cord-028721-x6f26ahr 298 5 testosterone testosterone NN cord-028721-x6f26ahr 298 6 levels level NNS cord-028721-x6f26ahr 298 7 Embryology embryology NN cord-028721-x6f26ahr 298 8 and and CC cord-028721-x6f26ahr 298 9 anatomy anatomy NN cord-028721-x6f26ahr 298 10 of of IN cord-028721-x6f26ahr 298 11 the the DT cord-028721-x6f26ahr 298 12 testis testis NN cord-028721-x6f26ahr 298 13 divide divide NN cord-028721-x6f26ahr 298 14 to to TO cord-028721-x6f26ahr 298 15 form form VB cord-028721-x6f26ahr 298 16 Ap Ap NNP cord-028721-x6f26ahr 298 17 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 298 18 ( ( -LRB- cord-028721-x6f26ahr 298 19 see see VB cord-028721-x6f26ahr 298 20 discussion discussion NN cord-028721-x6f26ahr 298 21 on on IN cord-028721-x6f26ahr 298 22 the the DT cord-028721-x6f26ahr 298 23 adult adult NN cord-028721-x6f26ahr 298 24 testis testis NN cord-028721-x6f26ahr 298 25 below below RB cord-028721-x6f26ahr 298 26 ) ) -RRB- cord-028721-x6f26ahr 298 27 . . . cord-028721-x6f26ahr 299 1 Six six CD cord-028721-x6f26ahr 299 2 months month NNS cord-028721-x6f26ahr 299 3 after after IN cord-028721-x6f26ahr 299 4 birth birth NN cord-028721-x6f26ahr 299 5 , , , cord-028721-x6f26ahr 299 6 gonocytes gonocyte NNS cord-028721-x6f26ahr 299 7 are be VBP cord-028721-x6f26ahr 299 8 absent absent JJ cord-028721-x6f26ahr 299 9 , , , cord-028721-x6f26ahr 299 10 coinciding coincide VBG cord-028721-x6f26ahr 299 11 with with IN cord-028721-x6f26ahr 299 12 the the DT cord-028721-x6f26ahr 299 13 loss loss NN cord-028721-x6f26ahr 299 14 of of IN cord-028721-x6f26ahr 299 15 fetal fetal JJ cord-028721-x6f26ahr 299 16 germ germ NN cord-028721-x6f26ahr 299 17 cell cell NN cord-028721-x6f26ahr 299 18 markers marker NNS cord-028721-x6f26ahr 299 19 ( ( -LRB- cord-028721-x6f26ahr 299 20 placental placental JJ cord-028721-x6f26ahr 299 21 alkaline alkaline JJ cord-028721-x6f26ahr 299 22 phosphatase phosphatase NN cord-028721-x6f26ahr 299 23 and and CC cord-028721-x6f26ahr 299 24 c c NN cord-028721-x6f26ahr 299 25 - - HYPH cord-028721-x6f26ahr 299 26 kit kit NN cord-028721-x6f26ahr 299 27 ) ) -RRB- cord-028721-x6f26ahr 299 28 . . . cord-028721-x6f26ahr 300 1 Paraganglia Paraganglia NNP cord-028721-x6f26ahr 300 2 are be VBP cord-028721-x6f26ahr 300 3 often often RB cord-028721-x6f26ahr 300 4 observed observe VBN cord-028721-x6f26ahr 300 5 in in IN cord-028721-x6f26ahr 300 6 epididymides epididymis NNS cord-028721-x6f26ahr 300 7 and and CC cord-028721-x6f26ahr 300 8 spermatic spermatic JJ cord-028721-x6f26ahr 300 9 cords cord NNS cord-028721-x6f26ahr 300 10 from from IN cord-028721-x6f26ahr 300 11 newborns newborn NNS cord-028721-x6f26ahr 300 12 . . . cord-028721-x6f26ahr 301 1 This this DT cord-028721-x6f26ahr 301 2 is be VBZ cord-028721-x6f26ahr 301 3 not not RB cord-028721-x6f26ahr 301 4 surprising surprising JJ cord-028721-x6f26ahr 301 5 , , , cord-028721-x6f26ahr 301 6 as as IN cord-028721-x6f26ahr 301 7 paraganglia paraganglia NNP cord-028721-x6f26ahr 301 8 are be VBP cord-028721-x6f26ahr 301 9 the the DT cord-028721-x6f26ahr 301 10 main main JJ cord-028721-x6f26ahr 301 11 source source NN cord-028721-x6f26ahr 301 12 of of IN cord-028721-x6f26ahr 301 13 catecholamine catecholamine NN cord-028721-x6f26ahr 301 14 before before IN cord-028721-x6f26ahr 301 15 birth birth NN cord-028721-x6f26ahr 302 1 ( ( -LRB- cord-028721-x6f26ahr 302 2 Fig Fig NNP cord-028721-x6f26ahr 302 3 . . . cord-028721-x6f26ahr 302 4 12 12 CD cord-028721-x6f26ahr 302 5 - - SYM cord-028721-x6f26ahr 302 6 14 14 CD cord-028721-x6f26ahr 302 7 ) ) -RRB- cord-028721-x6f26ahr 302 8 . . . cord-028721-x6f26ahr 303 1 92 92 CD cord-028721-x6f26ahr 304 1 The the DT cord-028721-x6f26ahr 304 2 testis testis NN cord-028721-x6f26ahr 304 3 in in IN cord-028721-x6f26ahr 304 4 infancy infancy NN cord-028721-x6f26ahr 304 5 From from IN cord-028721-x6f26ahr 304 6 the the DT cord-028721-x6f26ahr 304 7 sixth sixth JJ cord-028721-x6f26ahr 304 8 month month NN cord-028721-x6f26ahr 304 9 to to IN cord-028721-x6f26ahr 304 10 approximately approximately RB cord-028721-x6f26ahr 304 11 the the DT cord-028721-x6f26ahr 304 12 second second JJ cord-028721-x6f26ahr 304 13 half half NN cord-028721-x6f26ahr 304 14 of of IN cord-028721-x6f26ahr 304 15 the the DT cord-028721-x6f26ahr 304 16 third third JJ cord-028721-x6f26ahr 304 17 year year NN cord-028721-x6f26ahr 304 18 of of IN cord-028721-x6f26ahr 304 19 life life NN cord-028721-x6f26ahr 304 20 , , , cord-028721-x6f26ahr 304 21 the the DT cord-028721-x6f26ahr 304 22 testis testis NN cord-028721-x6f26ahr 304 23 is be VBZ cord-028721-x6f26ahr 304 24 in in IN cord-028721-x6f26ahr 304 25 a a DT cord-028721-x6f26ahr 304 26 resting rest VBG cord-028721-x6f26ahr 304 27 period period NN cord-028721-x6f26ahr 304 28 ; ; : cord-028721-x6f26ahr 304 29 this this DT cord-028721-x6f26ahr 304 30 quiescence quiescence NN cord-028721-x6f26ahr 304 31 is be VBZ cord-028721-x6f26ahr 304 32 broken break VBN cord-028721-x6f26ahr 304 33 by by IN cord-028721-x6f26ahr 304 34 the the DT cord-028721-x6f26ahr 304 35 second second JJ cord-028721-x6f26ahr 304 36 wave wave NN cord-028721-x6f26ahr 304 37 of of IN cord-028721-x6f26ahr 304 38 germ germ NN cord-028721-x6f26ahr 304 39 cell cell NN cord-028721-x6f26ahr 304 40 proliferation proliferation NN cord-028721-x6f26ahr 304 41 . . . cord-028721-x6f26ahr 305 1 93 93 CD cord-028721-x6f26ahr 306 1 The the DT cord-028721-x6f26ahr 306 2 number number NN cord-028721-x6f26ahr 306 3 of of IN cord-028721-x6f26ahr 306 4 Ap Ap NNP cord-028721-x6f26ahr 306 5 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 306 6 increases increase VBZ cord-028721-x6f26ahr 306 7 , , , cord-028721-x6f26ahr 306 8 and and CC cord-028721-x6f26ahr 306 9 B B NNP cord-028721-x6f26ahr 306 10 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 306 11 ( ( -LRB- cord-028721-x6f26ahr 306 12 derived derive VBN cord-028721-x6f26ahr 306 13 from from IN cord-028721-x6f26ahr 306 14 Ap Ap NNP cord-028721-x6f26ahr 306 15 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 306 16 ) ) -RRB- cord-028721-x6f26ahr 306 17 appear appear VBP cord-028721-x6f26ahr 306 18 . . . cord-028721-x6f26ahr 307 1 are be VBP cord-028721-x6f26ahr 307 2 similar similar JJ cord-028721-x6f26ahr 307 3 to to IN cord-028721-x6f26ahr 307 4 those those DT cord-028721-x6f26ahr 307 5 of of IN cord-028721-x6f26ahr 307 6 girls girl NNS cord-028721-x6f26ahr 307 7 , , , cord-028721-x6f26ahr 307 8 99 99 CD cord-028721-x6f26ahr 307 9 and and CC cord-028721-x6f26ahr 307 10 most most JJS cord-028721-x6f26ahr 307 11 androgens androgen NNS cord-028721-x6f26ahr 307 12 are be VBP cord-028721-x6f26ahr 307 13 of of IN cord-028721-x6f26ahr 307 14 adrenal adrenal JJ cord-028721-x6f26ahr 307 15 origin origin NN cord-028721-x6f26ahr 307 16 . . . cord-028721-x6f26ahr 308 1 At at IN cord-028721-x6f26ahr 308 2 about about RB cord-028721-x6f26ahr 308 3 9 9 CD cord-028721-x6f26ahr 308 4 years year NNS cord-028721-x6f26ahr 308 5 of of IN cord-028721-x6f26ahr 308 6 age age NN cord-028721-x6f26ahr 308 7 , , , cord-028721-x6f26ahr 308 8 the the DT cord-028721-x6f26ahr 308 9 third third JJ cord-028721-x6f26ahr 308 10 and and CC cord-028721-x6f26ahr 308 11 defi defi NNP cord-028721-x6f26ahr 308 12 nitive nitive NNP cord-028721-x6f26ahr 308 13 wave wave NN cord-028721-x6f26ahr 308 14 of of IN cord-028721-x6f26ahr 308 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 308 16 begins begin VBZ cord-028721-x6f26ahr 308 17 , , , cord-028721-x6f26ahr 308 18 101 101 CD cord-028721-x6f26ahr 308 19 coinciding coincide VBG cord-028721-x6f26ahr 308 20 with with IN cord-028721-x6f26ahr 308 21 a a DT cord-028721-x6f26ahr 308 22 signifi signifi NN cord-028721-x6f26ahr 309 1 ca can MD cord-028721-x6f26ahr 309 2 nt not RB cord-028721-x6f26ahr 309 3 elevation elevation NN cord-028721-x6f26ahr 309 4 of of IN cord-028721-x6f26ahr 309 5 LH LH NNP cord-028721-x6f26ahr 309 6 . . . cord-028721-x6f26ahr 310 1 This this DT cord-028721-x6f26ahr 310 2 is be VBZ cord-028721-x6f26ahr 310 3 followed follow VBN cord-028721-x6f26ahr 310 4 by by IN cord-028721-x6f26ahr 310 5 additional additional JJ cord-028721-x6f26ahr 310 6 increases increase NNS cord-028721-x6f26ahr 310 7 in in IN cord-028721-x6f26ahr 310 8 the the DT cord-028721-x6f26ahr 310 9 level level NN cord-028721-x6f26ahr 310 10 of of IN cord-028721-x6f26ahr 310 11 this this DT cord-028721-x6f26ahr 310 12 hormone hormone NN cord-028721-x6f26ahr 310 13 between between IN cord-028721-x6f26ahr 310 14 13 13 CD cord-028721-x6f26ahr 310 15 and and CC cord-028721-x6f26ahr 310 16 15 15 CD cord-028721-x6f26ahr 310 17 years year NNS cord-028721-x6f26ahr 310 18 of of IN cord-028721-x6f26ahr 310 19 age age NN cord-028721-x6f26ahr 310 20 . . . cord-028721-x6f26ahr 311 1 LH LH NNP cord-028721-x6f26ahr 311 2 induces induce VBZ cord-028721-x6f26ahr 311 3 fi fi NNP cord-028721-x6f26ahr 311 4 broblast broblast JJ cord-028721-x6f26ahr 311 5 - - HYPH cord-028721-x6f26ahr 311 6 like like JJ cord-028721-x6f26ahr 311 7 Leydig Leydig NNP cord-028721-x6f26ahr 311 8 cell cell NN cord-028721-x6f26ahr 311 9 precursors precursor NNS cord-028721-x6f26ahr 311 10 to to TO cord-028721-x6f26ahr 311 11 differentiate differentiate VB cord-028721-x6f26ahr 311 12 into into IN cord-028721-x6f26ahr 311 13 mature mature JJ cord-028721-x6f26ahr 311 14 Leydig Leydig NNP cord-028721-x6f26ahr 311 15 cells cell NNS cord-028721-x6f26ahr 311 16 . . . cord-028721-x6f26ahr 312 1 102 102 CD cord-028721-x6f26ahr 313 1 By by IN cord-028721-x6f26ahr 313 2 the the DT cord-028721-x6f26ahr 313 3 end end NN cord-028721-x6f26ahr 313 4 of of IN cord-028721-x6f26ahr 313 5 puberty puberty NN cord-028721-x6f26ahr 313 6 , , , cord-028721-x6f26ahr 313 7 the the DT cord-028721-x6f26ahr 313 8 population population NN cord-028721-x6f26ahr 313 9 of of IN cord-028721-x6f26ahr 313 10 Leydig Leydig NNP cord-028721-x6f26ahr 313 11 cells cell NNS cord-028721-x6f26ahr 313 12 per per IN cord-028721-x6f26ahr 313 13 testis testis NN cord-028721-x6f26ahr 313 14 has have VBZ cord-028721-x6f26ahr 313 15 risen rise VBN cord-028721-x6f26ahr 313 16 to to IN cord-028721-x6f26ahr 313 17 about about IN cord-028721-x6f26ahr 313 18 786 786 CD cord-028721-x6f26ahr 313 19 million million CD cord-028721-x6f26ahr 313 20 . . . cord-028721-x6f26ahr 314 1 103 103 CD cord-028721-x6f26ahr 315 1 Leydig leydig NN cord-028721-x6f26ahr 315 2 cells cell NNS cord-028721-x6f26ahr 315 3 secrete secrete VBP cord-028721-x6f26ahr 315 4 androgens androgen NNS cord-028721-x6f26ahr 315 5 , , , cord-028721-x6f26ahr 315 6 which which WDT cord-028721-x6f26ahr 315 7 , , , cord-028721-x6f26ahr 315 8 together together RB cord-028721-x6f26ahr 315 9 with with IN cord-028721-x6f26ahr 315 10 the the DT cord-028721-x6f26ahr 315 11 rise rise NN cord-028721-x6f26ahr 315 12 in in IN cord-028721-x6f26ahr 315 13 FSH fsh NN cord-028721-x6f26ahr 315 14 between between IN cord-028721-x6f26ahr 315 15 11 11 CD cord-028721-x6f26ahr 315 16 and and CC cord-028721-x6f26ahr 315 17 14 14 CD cord-028721-x6f26ahr 315 18 years year NNS cord-028721-x6f26ahr 315 19 of of IN cord-028721-x6f26ahr 315 20 age age NN cord-028721-x6f26ahr 315 21 , , , cord-028721-x6f26ahr 315 22 cause cause IN cord-028721-x6f26ahr 315 23 Sertoli sertoli JJ cord-028721-x6f26ahr 315 24 cell cell NN cord-028721-x6f26ahr 315 25 maturation maturation NN cord-028721-x6f26ahr 315 26 , , , cord-028721-x6f26ahr 315 27 germ germ NN cord-028721-x6f26ahr 315 28 cell cell NN cord-028721-x6f26ahr 315 29 development development NN cord-028721-x6f26ahr 315 30 , , , cord-028721-x6f26ahr 315 31 and and CC cord-028721-x6f26ahr 315 32 the the DT cord-028721-x6f26ahr 315 33 appearance appearance NN cord-028721-x6f26ahr 315 34 of of IN cord-028721-x6f26ahr 315 35 tubular tubular JJ cord-028721-x6f26ahr 315 36 lumina lumina NNP cord-028721-x6f26ahr 315 37 ( ( -LRB- cord-028721-x6f26ahr 315 38 Fig Fig NNP cord-028721-x6f26ahr 315 39 . . . cord-028721-x6f26ahr 315 40 12 12 CD cord-028721-x6f26ahr 315 41 - - SYM cord-028721-x6f26ahr 315 42 16 16 CD cord-028721-x6f26ahr 315 43 ) ) -RRB- cord-028721-x6f26ahr 315 44 , , , cord-028721-x6f26ahr 315 45 103 103 CD cord-028721-x6f26ahr 315 46 increasing increase VBG cord-028721-x6f26ahr 315 47 the the DT cord-028721-x6f26ahr 315 48 size size NN cord-028721-x6f26ahr 315 49 of of IN cord-028721-x6f26ahr 315 50 the the DT cord-028721-x6f26ahr 315 51 testes testis NNS cord-028721-x6f26ahr 315 52 between between IN cord-028721-x6f26ahr 315 53 the the DT cord-028721-x6f26ahr 315 54 ages age NNS cord-028721-x6f26ahr 315 55 of of IN cord-028721-x6f26ahr 315 56 11.5 11.5 CD cord-028721-x6f26ahr 315 57 and and CC cord-028721-x6f26ahr 315 58 12.5 12.5 CD cord-028721-x6f26ahr 315 59 years year NNS cord-028721-x6f26ahr 315 60 of of IN cord-028721-x6f26ahr 315 61 life life NN cord-028721-x6f26ahr 315 62 . . . cord-028721-x6f26ahr 316 1 104 104 CD cord-028721-x6f26ahr 317 1 At at IN cord-028721-x6f26ahr 317 2 13.5 13.5 CD cord-028721-x6f26ahr 317 3 years year NNS cord-028721-x6f26ahr 317 4 , , , cord-028721-x6f26ahr 317 5 before before IN cord-028721-x6f26ahr 317 6 the the DT cord-028721-x6f26ahr 317 7 testis testis NN cord-028721-x6f26ahr 317 8 reaches reach VBZ cord-028721-x6f26ahr 317 9 adult adult NN cord-028721-x6f26ahr 317 10 size size NN cord-028721-x6f26ahr 317 11 , , , cord-028721-x6f26ahr 317 12 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 317 13 are be VBP cord-028721-x6f26ahr 317 14 present present JJ cord-028721-x6f26ahr 317 15 , , , cord-028721-x6f26ahr 317 16 secondary secondary JJ cord-028721-x6f26ahr 317 17 sex sex NN cord-028721-x6f26ahr 317 18 characteristics characteristic NNS cord-028721-x6f26ahr 317 19 are be VBP cord-028721-x6f26ahr 317 20 completely completely RB cord-028721-x6f26ahr 317 21 developed develop VBN cord-028721-x6f26ahr 317 22 , , , cord-028721-x6f26ahr 317 23 and and CC cord-028721-x6f26ahr 317 24 the the DT cord-028721-x6f26ahr 317 25 epiphyses epiphyses NNPS cord-028721-x6f26ahr 317 26 close close VBP cord-028721-x6f26ahr 317 27 . . . cord-028721-x6f26ahr 318 1 105 105 CD cord-028721-x6f26ahr 318 2 _SP cord-028721-x6f26ahr 319 1 Testicular testicular JJ cord-028721-x6f26ahr 319 2 biopsy biopsy NN cord-028721-x6f26ahr 319 3 in in IN cord-028721-x6f26ahr 319 4 children child NNS cord-028721-x6f26ahr 319 5 is be VBZ cord-028721-x6f26ahr 319 6 useful useful JJ cord-028721-x6f26ahr 319 7 for for IN cord-028721-x6f26ahr 319 8 diagnosing diagnose VBG cord-028721-x6f26ahr 319 9 those those DT cord-028721-x6f26ahr 319 10 with with IN cord-028721-x6f26ahr 319 11 ambiguous ambiguous JJ cord-028721-x6f26ahr 319 12 genitalia genitalia NNS cord-028721-x6f26ahr 319 13 , , , cord-028721-x6f26ahr 319 14 a a DT cord-028721-x6f26ahr 319 15 history history NN cord-028721-x6f26ahr 319 16 of of IN cord-028721-x6f26ahr 319 17 leukemia leukemia NN cord-028721-x6f26ahr 319 18 or or CC cord-028721-x6f26ahr 319 19 lymphoma lymphoma NN cord-028721-x6f26ahr 319 20 whose whose WP$ cord-028721-x6f26ahr 319 21 testes testis NNS cord-028721-x6f26ahr 319 22 underwent undergo VBD cord-028721-x6f26ahr 319 23 a a DT cord-028721-x6f26ahr 319 24 rapid rapid JJ cord-028721-x6f26ahr 319 25 enlargement enlargement NN cord-028721-x6f26ahr 319 26 , , , cord-028721-x6f26ahr 319 27 or or CC cord-028721-x6f26ahr 319 28 precocious precocious JJ cord-028721-x6f26ahr 319 29 testicular testicular JJ cord-028721-x6f26ahr 319 30 maturation maturation NN cord-028721-x6f26ahr 319 31 of of IN cord-028721-x6f26ahr 319 32 unknown unknown JJ cord-028721-x6f26ahr 319 33 cause cause NN cord-028721-x6f26ahr 319 34 . . . cord-028721-x6f26ahr 320 1 In in IN cord-028721-x6f26ahr 320 2 other other JJ cord-028721-x6f26ahr 320 3 situations situation NNS cord-028721-x6f26ahr 320 4 , , , cord-028721-x6f26ahr 320 5 the the DT cord-028721-x6f26ahr 320 6 value value NN cord-028721-x6f26ahr 320 7 of of IN cord-028721-x6f26ahr 320 8 testicular testicular JJ cord-028721-x6f26ahr 320 9 biopsy biopsy NN cord-028721-x6f26ahr 320 10 is be VBZ cord-028721-x6f26ahr 320 11 less less RBR cord-028721-x6f26ahr 320 12 established established JJ cord-028721-x6f26ahr 320 13 . . . cord-028721-x6f26ahr 321 1 For for IN cord-028721-x6f26ahr 321 2 example example NN cord-028721-x6f26ahr 321 3 , , , cord-028721-x6f26ahr 321 4 the the DT cord-028721-x6f26ahr 321 5 value value NN cord-028721-x6f26ahr 321 6 of of IN cord-028721-x6f26ahr 321 7 biopsy biopsy NN cord-028721-x6f26ahr 321 8 of of IN cord-028721-x6f26ahr 321 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 321 10 testes testis NNS cord-028721-x6f26ahr 321 11 during during IN cord-028721-x6f26ahr 321 12 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 321 13 is be VBZ cord-028721-x6f26ahr 321 14 controversial controversial JJ cord-028721-x6f26ahr 321 15 . . . cord-028721-x6f26ahr 322 1 Evaluation evaluation NN cord-028721-x6f26ahr 322 2 of of IN cord-028721-x6f26ahr 322 3 biopsies biopsy NNS cord-028721-x6f26ahr 322 4 of of IN cord-028721-x6f26ahr 322 5 the the DT cord-028721-x6f26ahr 322 6 prepubertal prepubertal JJ cord-028721-x6f26ahr 322 7 testis testis NN cord-028721-x6f26ahr 322 8 should should MD cord-028721-x6f26ahr 322 9 involve involve VB cord-028721-x6f26ahr 322 10 the the DT cord-028721-x6f26ahr 322 11 assessment assessment NN cord-028721-x6f26ahr 322 12 of of IN cord-028721-x6f26ahr 322 13 several several JJ cord-028721-x6f26ahr 322 14 features feature NNS cord-028721-x6f26ahr 322 15 , , , cord-028721-x6f26ahr 322 16 including include VBG cord-028721-x6f26ahr 322 17 tunica tunica NNP cord-028721-x6f26ahr 322 18 albuginea albuginea NNP cord-028721-x6f26ahr 322 19 thickness thickness NN cord-028721-x6f26ahr 322 20 , , , cord-028721-x6f26ahr 322 21 mean mean VB cord-028721-x6f26ahr 322 22 tubular tubular JJ cord-028721-x6f26ahr 322 23 diameter diameter NN cord-028721-x6f26ahr 322 24 , , , cord-028721-x6f26ahr 322 25 and and CC cord-028721-x6f26ahr 322 26 the the DT cord-028721-x6f26ahr 322 27 number number NN cord-028721-x6f26ahr 322 28 of of IN cord-028721-x6f26ahr 322 29 germ germ NN cord-028721-x6f26ahr 322 30 cells cell NNS cord-028721-x6f26ahr 322 31 , , , cord-028721-x6f26ahr 322 32 Sertoli sertoli JJ cord-028721-x6f26ahr 322 33 cells cell NNS cord-028721-x6f26ahr 322 34 , , , cord-028721-x6f26ahr 322 35 and and CC cord-028721-x6f26ahr 322 36 Leydig leydig NN cord-028721-x6f26ahr 322 37 cells cell NNS cord-028721-x6f26ahr 322 38 . . . cord-028721-x6f26ahr 323 1 The the DT cord-028721-x6f26ahr 323 2 most most RBS cord-028721-x6f26ahr 323 3 frequent frequent JJ cord-028721-x6f26ahr 323 4 anomalies anomaly NNS cord-028721-x6f26ahr 323 5 of of IN cord-028721-x6f26ahr 323 6 the the DT cord-028721-x6f26ahr 323 7 tunica tunica NNP cord-028721-x6f26ahr 323 8 albuginea albuginea NNP cord-028721-x6f26ahr 323 9 include include VBP cord-028721-x6f26ahr 323 10 thin thin JJ cord-028721-x6f26ahr 323 11 , , , cord-028721-x6f26ahr 323 12 poorly poorly RB cord-028721-x6f26ahr 323 13 collagenized collagenize VBN cord-028721-x6f26ahr 323 14 tunica tunica NNP cord-028721-x6f26ahr 323 15 albuginea albuginea NNP cord-028721-x6f26ahr 323 16 with with IN cord-028721-x6f26ahr 323 17 abnormal abnormal JJ cord-028721-x6f26ahr 323 18 tubules tubule NNS cord-028721-x6f26ahr 323 19 typical typical JJ cord-028721-x6f26ahr 323 20 of of IN cord-028721-x6f26ahr 323 21 testicular testicular JJ cord-028721-x6f26ahr 323 22 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 323 23 ( ( -LRB- cord-028721-x6f26ahr 323 24 see see VB cord-028721-x6f26ahr 323 25 the the DT cord-028721-x6f26ahr 323 26 section section NN cord-028721-x6f26ahr 323 27 on on IN cord-028721-x6f26ahr 323 28 male male JJ cord-028721-x6f26ahr 323 29 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 323 30 with with IN cord-028721-x6f26ahr 323 31 müllerian müllerian JJ cord-028721-x6f26ahr 323 32 remnants remnant NNS cord-028721-x6f26ahr 323 33 , , , cord-028721-x6f26ahr 323 34 below below RB cord-028721-x6f26ahr 323 35 ) ) -RRB- cord-028721-x6f26ahr 323 36 ; ; : cord-028721-x6f26ahr 323 37 well well RB cord-028721-x6f26ahr 323 38 - - HYPH cord-028721-x6f26ahr 323 39 collagenized collagenize VBN cord-028721-x6f26ahr 323 40 tunica tunica NNP cord-028721-x6f26ahr 323 41 albuginea albuginea NNP cord-028721-x6f26ahr 323 42 containing contain VBG cord-028721-x6f26ahr 323 43 ectopic ectopic JJ cord-028721-x6f26ahr 323 44 seminiferous seminiferous JJ cord-028721-x6f26ahr 323 45 tubules tubule NNS cord-028721-x6f26ahr 323 46 , , , cord-028721-x6f26ahr 323 47 a a DT cord-028721-x6f26ahr 323 48 frequent frequent JJ cord-028721-x6f26ahr 323 49 fi fi NN cord-028721-x6f26ahr 323 50 nding nding NN cord-028721-x6f26ahr 323 51 in in IN cord-028721-x6f26ahr 323 52 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 323 53 ; ; : cord-028721-x6f26ahr 323 54 and and CC cord-028721-x6f26ahr 323 55 poorly poorly RB cord-028721-x6f26ahr 323 56 collagenized collagenize VBN cord-028721-x6f26ahr 323 57 tunica tunica NNP cord-028721-x6f26ahr 323 58 albuginea albuginea NNP cord-028721-x6f26ahr 323 59 containing contain VBG cord-028721-x6f26ahr 323 60 ovocytes ovocytes NNP cord-028721-x6f26ahr 323 61 characteristic characteristic NN cord-028721-x6f26ahr 323 62 of of IN cord-028721-x6f26ahr 323 63 true true JJ cord-028721-x6f26ahr 323 64 hermaphroditic hermaphroditic JJ cord-028721-x6f26ahr 323 65 ovotestes ovotestis NNS cord-028721-x6f26ahr 323 66 . . . cord-028721-x6f26ahr 324 1 The the DT cord-028721-x6f26ahr 324 2 mean mean JJ cord-028721-x6f26ahr 324 3 tubular tubular JJ cord-028721-x6f26ahr 324 4 diameter diameter NN cord-028721-x6f26ahr 324 5 is be VBZ cord-028721-x6f26ahr 324 6 an an DT cord-028721-x6f26ahr 324 7 excellent excellent JJ cord-028721-x6f26ahr 324 8 indicator indicator NN cord-028721-x6f26ahr 324 9 of of IN cord-028721-x6f26ahr 324 10 the the DT cord-028721-x6f26ahr 324 11 development development NN cord-028721-x6f26ahr 324 12 of of IN cord-028721-x6f26ahr 324 13 the the DT cord-028721-x6f26ahr 324 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 324 15 epithelium epithelium NN cord-028721-x6f26ahr 324 16 . . . cord-028721-x6f26ahr 325 1 In in IN cord-028721-x6f26ahr 325 2 the the DT cord-028721-x6f26ahr 325 3 prepubertal prepubertal JJ cord-028721-x6f26ahr 325 4 testis testis NN cord-028721-x6f26ahr 325 5 , , , cord-028721-x6f26ahr 325 6 tubular tubular JJ cord-028721-x6f26ahr 325 7 diameter diameter NN cord-028721-x6f26ahr 325 8 depends depend VBZ cord-028721-x6f26ahr 325 9 principally principally RB cord-028721-x6f26ahr 325 10 on on IN cord-028721-x6f26ahr 325 11 the the DT cord-028721-x6f26ahr 325 12 Sertoli Sertoli NNP cord-028721-x6f26ahr 325 13 cells cell NNS cord-028721-x6f26ahr 325 14 and and CC cord-028721-x6f26ahr 325 15 thus thus RB cord-028721-x6f26ahr 325 16 indicates indicate VBZ cord-028721-x6f26ahr 325 17 whether whether IN cord-028721-x6f26ahr 325 18 they -PRON- PRP cord-028721-x6f26ahr 325 19 are be VBP cord-028721-x6f26ahr 325 20 adequately adequately RB cord-028721-x6f26ahr 325 21 stimulated stimulate VBN cord-028721-x6f26ahr 325 22 by by IN cord-028721-x6f26ahr 325 23 FSH fsh NN cord-028721-x6f26ahr 325 24 . . . cord-028721-x6f26ahr 326 1 Tubular tubular JJ cord-028721-x6f26ahr 326 2 diameter diameter NN cord-028721-x6f26ahr 326 3 varies vary VBZ cord-028721-x6f26ahr 326 4 throughout throughout RB cord-028721-x6f26ahr 326 5 , , , cord-028721-x6f26ahr 326 6 being be VBG cord-028721-x6f26ahr 326 7 smallest small JJS cord-028721-x6f26ahr 326 8 in in IN cord-028721-x6f26ahr 326 9 the the DT cord-028721-x6f26ahr 326 10 end end NN cord-028721-x6f26ahr 326 11 of of IN cord-028721-x6f26ahr 326 12 the the DT cord-028721-x6f26ahr 326 13 third third JJ cord-028721-x6f26ahr 326 14 year year NN cord-028721-x6f26ahr 326 15 of of IN cord-028721-x6f26ahr 326 16 life life NN cord-028721-x6f26ahr 326 17 , , , cord-028721-x6f26ahr 326 18 slowly slowly RB cord-028721-x6f26ahr 326 19 enlarging enlarge VBG cord-028721-x6f26ahr 326 20 up up RP cord-028721-x6f26ahr 326 21 to to TO cord-028721-x6f26ahr 326 22 9 9 CD cord-028721-x6f26ahr 326 23 years year NNS cord-028721-x6f26ahr 326 24 of of IN cord-028721-x6f26ahr 326 25 age age NN cord-028721-x6f26ahr 326 26 , , , cord-028721-x6f26ahr 326 27 and and CC cord-028721-x6f26ahr 326 28 rapidly rapidly RB cord-028721-x6f26ahr 326 29 enlarging enlarge VBG cord-028721-x6f26ahr 326 30 thereafter thereafter RB cord-028721-x6f26ahr 326 31 up up IN cord-028721-x6f26ahr 326 32 to to TO cord-028721-x6f26ahr 326 33 15 15 CD cord-028721-x6f26ahr 326 34 years year NNS cord-028721-x6f26ahr 327 1 ( ( -LRB- cord-028721-x6f26ahr 327 2 Fig Fig NNP cord-028721-x6f26ahr 327 3 . . . cord-028721-x6f26ahr 327 4 12 12 CD cord-028721-x6f26ahr 327 5 - - SYM cord-028721-x6f26ahr 327 6 17 17 CD cord-028721-x6f26ahr 327 7 ) ) -RRB- cord-028721-x6f26ahr 327 8 . . . cord-028721-x6f26ahr 328 1 The the DT cord-028721-x6f26ahr 328 2 most most RBS cord-028721-x6f26ahr 328 3 frequent frequent JJ cord-028721-x6f26ahr 328 4 abnormality abnormality NN cord-028721-x6f26ahr 328 5 in in IN cord-028721-x6f26ahr 328 6 the the DT cord-028721-x6f26ahr 328 7 prepubertal prepubertal JJ cord-028721-x6f26ahr 328 8 testis testis NN cord-028721-x6f26ahr 328 9 is be VBZ cord-028721-x6f26ahr 328 10 a a DT cord-028721-x6f26ahr 328 11 low low JJ cord-028721-x6f26ahr 328 12 mean mean NN cord-028721-x6f26ahr 328 13 tubular tubular JJ cord-028721-x6f26ahr 328 14 diameter diameter NN cord-028721-x6f26ahr 328 15 . . . cord-028721-x6f26ahr 329 1 This this DT cord-028721-x6f26ahr 329 2 is be VBZ cord-028721-x6f26ahr 329 3 seen see VBN cord-028721-x6f26ahr 329 4 in in IN cord-028721-x6f26ahr 329 5 undescended undescended JJ cord-028721-x6f26ahr 329 6 testes testis NNS cord-028721-x6f26ahr 329 7 as as RB cord-028721-x6f26ahr 329 8 well well RB cord-028721-x6f26ahr 329 9 as as IN cord-028721-x6f26ahr 329 10 in in IN cord-028721-x6f26ahr 329 11 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 329 12 or or CC cord-028721-x6f26ahr 329 13 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 329 14 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 329 15 . . . cord-028721-x6f26ahr 330 1 In in IN cord-028721-x6f26ahr 330 2 the the DT cord-028721-x6f26ahr 330 3 latter latter JJ cord-028721-x6f26ahr 330 4 , , , cord-028721-x6f26ahr 330 5 the the DT cord-028721-x6f26ahr 330 6 lesion lesion NN cord-028721-x6f26ahr 330 7 results result VBZ cord-028721-x6f26ahr 330 8 from from IN cord-028721-x6f26ahr 330 9 anomalous anomalous JJ cord-028721-x6f26ahr 330 10 Sertoli sertoli JJ cord-028721-x6f26ahr 330 11 cell cell NN cord-028721-x6f26ahr 330 12 responsiveness responsiveness NN cord-028721-x6f26ahr 330 13 to to IN cord-028721-x6f26ahr 330 14 FSH FSH NNP cord-028721-x6f26ahr 330 15 . . . cord-028721-x6f26ahr 331 1 106 106 CD cord-028721-x6f26ahr 332 1 There there EX cord-028721-x6f26ahr 332 2 are be VBP cord-028721-x6f26ahr 332 3 three three CD cord-028721-x6f26ahr 332 4 levels level NNS cord-028721-x6f26ahr 332 5 of of IN cord-028721-x6f26ahr 332 6 severity severity NN cord-028721-x6f26ahr 332 7 of of IN cord-028721-x6f26ahr 332 8 low low JJ cord-028721-x6f26ahr 332 9 tubular tubular JJ cord-028721-x6f26ahr 332 10 diameter diameter NN cord-028721-x6f26ahr 332 11 : : : cord-028721-x6f26ahr 332 12 slight slight JJ cord-028721-x6f26ahr 332 13 tubular tubular JJ cord-028721-x6f26ahr 332 14 hypoplasia hypoplasia NN cord-028721-x6f26ahr 332 15 ( ( -LRB- cord-028721-x6f26ahr 332 16 up up IN cord-028721-x6f26ahr 332 17 to to TO cord-028721-x6f26ahr 332 18 10 10 CD cord-028721-x6f26ahr 332 19 % % NN cord-028721-x6f26ahr 332 20 reduction reduction NN cord-028721-x6f26ahr 332 21 in in IN cord-028721-x6f26ahr 332 22 relation relation NN cord-028721-x6f26ahr 332 23 to to IN cord-028721-x6f26ahr 332 24 the the DT cord-028721-x6f26ahr 332 25 diameter diameter NN cord-028721-x6f26ahr 332 26 normal normal JJ cord-028721-x6f26ahr 332 27 for for IN cord-028721-x6f26ahr 332 28 the the DT cord-028721-x6f26ahr 332 29 age age NN cord-028721-x6f26ahr 332 30 ) ) -RRB- cord-028721-x6f26ahr 332 31 ; ; , cord-028721-x6f26ahr 332 32 marked mark VBD cord-028721-x6f26ahr 332 33 tubular tubular JJ cord-028721-x6f26ahr 332 34 hypoplasia hypoplasia NN cord-028721-x6f26ahr 332 35 ( ( -LRB- cord-028721-x6f26ahr 332 36 from from IN cord-028721-x6f26ahr 332 37 10 10 CD cord-028721-x6f26ahr 332 38 % % NN cord-028721-x6f26ahr 332 39 to to TO cord-028721-x6f26ahr 332 40 30 30 CD cord-028721-x6f26ahr 332 41 % % NN cord-028721-x6f26ahr 332 42 reduction reduction NN cord-028721-x6f26ahr 332 43 ) ) -RRB- cord-028721-x6f26ahr 332 44 ; ; : cord-028721-x6f26ahr 332 45 and and CC cord-028721-x6f26ahr 332 46 severe severe JJ cord-028721-x6f26ahr 332 47 tubular tubular JJ cord-028721-x6f26ahr 332 48 hypoplasia hypoplasia NN cord-028721-x6f26ahr 332 49 ( ( -LRB- cord-028721-x6f26ahr 332 50 more more JJR cord-028721-x6f26ahr 332 51 than than IN cord-028721-x6f26ahr 332 52 30 30 CD cord-028721-x6f26ahr 332 53 % % NN cord-028721-x6f26ahr 332 54 reduction reduction NN cord-028721-x6f26ahr 332 55 ) ) -RRB- cord-028721-x6f26ahr 332 56 . . . cord-028721-x6f26ahr 333 1 Many many JJ cord-028721-x6f26ahr 333 2 testicular testicular JJ cord-028721-x6f26ahr 333 3 biopsies biopsy NNS cord-028721-x6f26ahr 333 4 show show VBP cord-028721-x6f26ahr 333 5 malformed malformed JJ cord-028721-x6f26ahr 333 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 333 7 tubules tubule NNS cord-028721-x6f26ahr 333 8 that that WDT cord-028721-x6f26ahr 333 9 vary vary VBP cord-028721-x6f26ahr 333 10 from from IN cord-028721-x6f26ahr 333 11 straight straight RB cord-028721-x6f26ahr 333 12 or or CC cord-028721-x6f26ahr 333 13 branched branched JJ cord-028721-x6f26ahr 333 14 tubules tubule NNS cord-028721-x6f26ahr 333 15 up up RP cord-028721-x6f26ahr 333 16 to to IN cord-028721-x6f26ahr 333 17 ring ring NN cord-028721-x6f26ahr 333 18 - - HYPH cord-028721-x6f26ahr 333 19 shaped shape VBN cord-028721-x6f26ahr 333 20 . . . cord-028721-x6f26ahr 334 1 These these DT cord-028721-x6f26ahr 334 2 are be VBP cord-028721-x6f26ahr 334 3 megatubules megatubule NNS cord-028721-x6f26ahr 334 4 formed form VBN cord-028721-x6f26ahr 334 5 by by IN cord-028721-x6f26ahr 334 6 either either CC cord-028721-x6f26ahr 334 7 tight tight JJ cord-028721-x6f26ahr 334 8 spiral spiral NN cord-028721-x6f26ahr 334 9 or or CC cord-028721-x6f26ahr 334 10 bell bell NN cord-028721-x6f26ahr 334 11 - - HYPH cord-028721-x6f26ahr 334 12 shaped shape VBN cord-028721-x6f26ahr 334 13 tubules tubule NNS cord-028721-x6f26ahr 334 14 . . . cord-028721-x6f26ahr 335 1 The the DT cord-028721-x6f26ahr 335 2 presence presence NN cord-028721-x6f26ahr 335 3 of of IN cord-028721-x6f26ahr 335 4 these these DT cord-028721-x6f26ahr 335 5 malformations malformation NNS cord-028721-x6f26ahr 335 6 suggests suggest VBZ cord-028721-x6f26ahr 335 7 the the DT cord-028721-x6f26ahr 335 8 child child NN cord-028721-x6f26ahr 335 9 will will MD cord-028721-x6f26ahr 335 10 be be VB cord-028721-x6f26ahr 335 11 infertile infertile JJ cord-028721-x6f26ahr 335 12 in in IN cord-028721-x6f26ahr 335 13 adulthood adulthood NN cord-028721-x6f26ahr 335 14 . . . cord-028721-x6f26ahr 336 1 Diffuse diffuse JJ cord-028721-x6f26ahr 336 2 increase increase NN cord-028721-x6f26ahr 336 3 in in IN cord-028721-x6f26ahr 336 4 mean mean JJ cord-028721-x6f26ahr 336 5 tubular tubular JJ cord-028721-x6f26ahr 336 6 diameter diameter NN cord-028721-x6f26ahr 336 7 may may MD cord-028721-x6f26ahr 336 8 be be VB cord-028721-x6f26ahr 336 9 unilateral unilateral JJ cord-028721-x6f26ahr 336 10 or or CC cord-028721-x6f26ahr 336 11 bilateral bilateral JJ cord-028721-x6f26ahr 336 12 . . . cord-028721-x6f26ahr 337 1 Unilateral unilateral JJ cord-028721-x6f26ahr 337 2 increase increase NN cord-028721-x6f26ahr 337 3 is be VBZ cord-028721-x6f26ahr 337 4 found find VBN cord-028721-x6f26ahr 337 5 in in IN cord-028721-x6f26ahr 337 6 monorchidism monorchidism NN cord-028721-x6f26ahr 337 7 ( ( -LRB- cord-028721-x6f26ahr 337 8 compensatory compensatory JJ cord-028721-x6f26ahr 337 9 testicular testicular JJ cord-028721-x6f26ahr 337 10 hypertrophy hypertrophy NN cord-028721-x6f26ahr 337 11 ) ) -RRB- cord-028721-x6f26ahr 337 12 and and CC cord-028721-x6f26ahr 337 13 some some DT cord-028721-x6f26ahr 337 14 testes testis NNS cord-028721-x6f26ahr 337 15 that that WDT cord-028721-x6f26ahr 337 16 are be VBP cord-028721-x6f26ahr 337 17 contralateral contralateral JJ cord-028721-x6f26ahr 337 18 to to IN cord-028721-x6f26ahr 337 19 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 337 20 testes testis NNS cord-028721-x6f26ahr 337 21 . . . cord-028721-x6f26ahr 338 1 Most most RBS cord-028721-x6f26ahr 338 2 frequently frequently RB cord-028721-x6f26ahr 338 3 , , , cord-028721-x6f26ahr 338 4 diffuse diffuse VBP cord-028721-x6f26ahr 338 5 enlargement enlargement NN cord-028721-x6f26ahr 338 6 occurs occur VBZ cord-028721-x6f26ahr 338 7 with with IN cord-028721-x6f26ahr 338 8 benign benign JJ cord-028721-x6f26ahr 338 9 idiopathic idiopathic JJ cord-028721-x6f26ahr 338 10 macroorchidism macroorchidism NN cord-028721-x6f26ahr 338 11 or or CC cord-028721-x6f26ahr 338 12 macroorchidism macroorchidism NN cord-028721-x6f26ahr 338 13 associated associate VBN cord-028721-x6f26ahr 338 14 with with IN cord-028721-x6f26ahr 338 15 fragile fragile JJ cord-028721-x6f26ahr 338 16 X x NN cord-028721-x6f26ahr 338 17 chromosome chromosome NN cord-028721-x6f26ahr 338 18 , , , cord-028721-x6f26ahr 338 19 familial familial JJ cord-028721-x6f26ahr 338 20 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 338 21 , , , cord-028721-x6f26ahr 338 22 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 338 23 , , , cord-028721-x6f26ahr 338 24 or or CC cord-028721-x6f26ahr 338 25 different different JJ cord-028721-x6f26ahr 338 26 forms form NNS cord-028721-x6f26ahr 338 27 of of IN cord-028721-x6f26ahr 338 28 precocious precocious JJ cord-028721-x6f26ahr 338 29 puberty puberty NN cord-028721-x6f26ahr 338 30 . . . cord-028721-x6f26ahr 339 1 Focal focal JJ cord-028721-x6f26ahr 339 2 increases increase NNS cord-028721-x6f26ahr 339 3 in in IN cord-028721-x6f26ahr 339 4 mean mean NN cord-028721-x6f26ahr 340 1 tubular tubular JJ cord-028721-x6f26ahr 340 2 diameter diameter NN cord-028721-x6f26ahr 340 3 are be VBP cord-028721-x6f26ahr 340 4 usually usually RB cord-028721-x6f26ahr 340 5 associated associate VBN cord-028721-x6f26ahr 340 6 with with IN cord-028721-x6f26ahr 340 7 precocious precocious JJ cord-028721-x6f26ahr 340 8 maturation maturation NN cord-028721-x6f26ahr 340 9 of of IN cord-028721-x6f26ahr 340 10 the the DT cord-028721-x6f26ahr 340 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 340 12 epithelium epithelium NN cord-028721-x6f26ahr 340 13 layers layer NNS cord-028721-x6f26ahr 340 14 , , , cord-028721-x6f26ahr 340 15 and and CC cord-028721-x6f26ahr 340 16 occur occur VBP cord-028721-x6f26ahr 340 17 at at IN cord-028721-x6f26ahr 340 18 the the DT cord-028721-x6f26ahr 340 19 periphery periphery NN cord-028721-x6f26ahr 340 20 of of IN cord-028721-x6f26ahr 340 21 some some DT cord-028721-x6f26ahr 340 22 Sertoli sertoli JJ cord-028721-x6f26ahr 340 23 cell cell NN cord-028721-x6f26ahr 340 24 and and CC cord-028721-x6f26ahr 340 25 Leydig leydig NN cord-028721-x6f26ahr 340 26 cell cell NN cord-028721-x6f26ahr 340 27 tumors tumor NNS cord-028721-x6f26ahr 340 28 . . . cord-028721-x6f26ahr 341 1 Germ germ NN cord-028721-x6f26ahr 341 2 cells cell NNS cord-028721-x6f26ahr 341 3 can can MD cord-028721-x6f26ahr 341 4 be be VB cord-028721-x6f26ahr 341 5 counted count VBN cord-028721-x6f26ahr 341 6 in in IN cord-028721-x6f26ahr 341 7 two two CD cord-028721-x6f26ahr 341 8 ways way NNS cord-028721-x6f26ahr 341 9 : : : cord-028721-x6f26ahr 341 10 calculation calculation NN cord-028721-x6f26ahr 341 11 of of IN cord-028721-x6f26ahr 341 12 the the DT cord-028721-x6f26ahr 341 13 number number NN cord-028721-x6f26ahr 341 14 of of IN cord-028721-x6f26ahr 341 15 cells cell NNS cord-028721-x6f26ahr 341 16 per per IN cord-028721-x6f26ahr 341 17 tubular tubular JJ cord-028721-x6f26ahr 341 18 cross cross JJ cord-028721-x6f26ahr 341 19 - - NN cord-028721-x6f26ahr 341 20 section section NN cord-028721-x6f26ahr 341 21 , , , cord-028721-x6f26ahr 341 22 or or CC cord-028721-x6f26ahr 341 23 determination determination NN cord-028721-x6f26ahr 341 24 of of IN cord-028721-x6f26ahr 341 25 the the DT cord-028721-x6f26ahr 341 26 tubular tubular JJ cord-028721-x6f26ahr 341 27 fertility fertility NN cord-028721-x6f26ahr 341 28 index index NN cord-028721-x6f26ahr 341 29 . . . cord-028721-x6f26ahr 342 1 The the DT cord-028721-x6f26ahr 342 2 former former JJ cord-028721-x6f26ahr 342 3 counts count VBZ cord-028721-x6f26ahr 342 4 the the DT cord-028721-x6f26ahr 342 5 number number NN cord-028721-x6f26ahr 342 6 of of IN cord-028721-x6f26ahr 342 7 germ germ NN cord-028721-x6f26ahr 342 8 cells cell NNS cord-028721-x6f26ahr 342 9 in in IN cord-028721-x6f26ahr 342 10 a a DT cord-028721-x6f26ahr 342 11 light light JJ cord-028721-x6f26ahr 342 12 microscopic microscopic JJ cord-028721-x6f26ahr 342 13 fi fi NN cord-028721-x6f26ahr 342 14 eld eld NN cord-028721-x6f26ahr 342 15 and and CC cord-028721-x6f26ahr 342 16 divides divide VBZ cord-028721-x6f26ahr 342 17 this this DT cord-028721-x6f26ahr 342 18 by by IN cord-028721-x6f26ahr 342 19 the the DT cord-028721-x6f26ahr 342 20 number number NN cord-028721-x6f26ahr 342 21 of of IN cord-028721-x6f26ahr 342 22 cross cross JJ cord-028721-x6f26ahr 342 23 - - JJ cord-028721-x6f26ahr 342 24 sectioned section VBN cord-028721-x6f26ahr 342 25 tubules tubule NNS cord-028721-x6f26ahr 342 26 in in IN cord-028721-x6f26ahr 342 27 the the DT cord-028721-x6f26ahr 342 28 same same JJ cord-028721-x6f26ahr 342 29 fi fi NN cord-028721-x6f26ahr 342 30 eld eld NN cord-028721-x6f26ahr 342 31 . . . cord-028721-x6f26ahr 343 1 In in IN cord-028721-x6f26ahr 343 2 the the DT cord-028721-x6f26ahr 343 3 fi fi NN cord-028721-x6f26ahr 343 4 rst rst NNP cord-028721-x6f26ahr 343 5 6 6 CD cord-028721-x6f26ahr 343 6 months month NNS cord-028721-x6f26ahr 343 7 of of IN cord-028721-x6f26ahr 343 8 postnatal postnatal JJ cord-028721-x6f26ahr 343 9 life life NN cord-028721-x6f26ahr 343 10 the the DT cord-028721-x6f26ahr 343 11 normal normal JJ cord-028721-x6f26ahr 343 12 testis testis NN cord-028721-x6f26ahr 343 13 has have VBZ cord-028721-x6f26ahr 343 14 two two CD cord-028721-x6f26ahr 343 15 germ germ NN cord-028721-x6f26ahr 343 16 cells cell NNS cord-028721-x6f26ahr 343 17 per per IN cord-028721-x6f26ahr 343 18 cross cross JJ cord-028721-x6f26ahr 343 19 - - JJ cord-028721-x6f26ahr 343 20 sectioned section VBN cord-028721-x6f26ahr 343 21 tubule tubule NN cord-028721-x6f26ahr 343 22 . . . cord-028721-x6f26ahr 344 1 This this DT cord-028721-x6f26ahr 344 2 number number NN cord-028721-x6f26ahr 344 3 drops drop VBZ cord-028721-x6f26ahr 344 4 to to IN cord-028721-x6f26ahr 344 5 1.5 1.5 CD cord-028721-x6f26ahr 344 6 at at IN cord-028721-x6f26ahr 344 7 the the DT cord-028721-x6f26ahr 344 8 end end NN cord-028721-x6f26ahr 344 9 of of IN cord-028721-x6f26ahr 344 10 the the DT cord-028721-x6f26ahr 344 11 fi fi NNP cord-028721-x6f26ahr 344 12 rst rst NNP cord-028721-x6f26ahr 344 13 year year NN cord-028721-x6f26ahr 344 14 and and CC cord-028721-x6f26ahr 344 15 to to IN cord-028721-x6f26ahr 344 16 0.5 0.5 CD cord-028721-x6f26ahr 344 17 at at IN cord-028721-x6f26ahr 344 18 the the DT cord-028721-x6f26ahr 344 19 end end NN cord-028721-x6f26ahr 344 20 of of IN cord-028721-x6f26ahr 344 21 the the DT cord-028721-x6f26ahr 344 22 third third JJ cord-028721-x6f26ahr 344 23 year year NN cord-028721-x6f26ahr 344 24 . . . cord-028721-x6f26ahr 345 1 The the DT cord-028721-x6f26ahr 345 2 number number NN cord-028721-x6f26ahr 345 3 of of IN cord-028721-x6f26ahr 345 4 germ germ NN cord-028721-x6f26ahr 345 5 cells cell NNS cord-028721-x6f26ahr 345 6 increases increase VBZ cord-028721-x6f26ahr 345 7 to to IN cord-028721-x6f26ahr 345 8 1.8 1.8 CD cord-028721-x6f26ahr 345 9 cells cell NNS cord-028721-x6f26ahr 345 10 at at IN cord-028721-x6f26ahr 345 11 the the DT cord-028721-x6f26ahr 345 12 age age NN cord-028721-x6f26ahr 345 13 of of IN cord-028721-x6f26ahr 345 14 3 3 CD cord-028721-x6f26ahr 345 15 - - SYM cord-028721-x6f26ahr 345 16 4 4 CD cord-028721-x6f26ahr 345 17 years year NNS cord-028721-x6f26ahr 345 18 , , , cord-028721-x6f26ahr 345 19 which which WDT cord-028721-x6f26ahr 345 20 coincides coincide VBZ cord-028721-x6f26ahr 345 21 with with IN cord-028721-x6f26ahr 345 22 the the DT cord-028721-x6f26ahr 345 23 appearance appearance NN cord-028721-x6f26ahr 345 24 of of IN cord-028721-x6f26ahr 345 25 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 345 26 in in IN cord-028721-x6f26ahr 345 27 some some DT cord-028721-x6f26ahr 345 28 tubules tubule NNS cord-028721-x6f26ahr 345 29 . . . cord-028721-x6f26ahr 346 1 The the DT cord-028721-x6f26ahr 346 2 tubular tubular JJ cord-028721-x6f26ahr 346 3 fertility fertility NN cord-028721-x6f26ahr 346 4 index index NN cord-028721-x6f26ahr 346 5 refl refl NNP cord-028721-x6f26ahr 346 6 ects ect VBZ cord-028721-x6f26ahr 346 7 the the DT cord-028721-x6f26ahr 346 8 percentage percentage NN cord-028721-x6f26ahr 346 9 of of IN cord-028721-x6f26ahr 346 10 tubular tubular JJ cord-028721-x6f26ahr 346 11 sections section NNS cord-028721-x6f26ahr 346 12 containing contain VBG cord-028721-x6f26ahr 346 13 germ germ NN cord-028721-x6f26ahr 346 14 cells cell NNS cord-028721-x6f26ahr 346 15 . . . cord-028721-x6f26ahr 347 1 In in IN cord-028721-x6f26ahr 347 2 newborns newborn NNS cord-028721-x6f26ahr 347 3 , , , cord-028721-x6f26ahr 347 4 68 68 CD cord-028721-x6f26ahr 347 5 % % NN cord-028721-x6f26ahr 347 6 of of IN cord-028721-x6f26ahr 347 7 tubular tubular JJ cord-028721-x6f26ahr 347 8 sections section NNS cord-028721-x6f26ahr 347 9 contain contain VBP cord-028721-x6f26ahr 347 10 at at IN cord-028721-x6f26ahr 347 11 least least RBS cord-028721-x6f26ahr 347 12 one one CD cord-028721-x6f26ahr 347 13 germ germ NN cord-028721-x6f26ahr 347 14 cell cell NN cord-028721-x6f26ahr 347 15 . . . cord-028721-x6f26ahr 348 1 From from IN cord-028721-x6f26ahr 348 2 birth birth NN cord-028721-x6f26ahr 348 3 to to IN cord-028721-x6f26ahr 348 4 3 3 CD cord-028721-x6f26ahr 348 5 years year NNS cord-028721-x6f26ahr 348 6 this this DT cord-028721-x6f26ahr 348 7 decreases decrease VBZ cord-028721-x6f26ahr 348 8 to to IN cord-028721-x6f26ahr 348 9 50 50 CD cord-028721-x6f26ahr 348 10 % % NN cord-028721-x6f26ahr 348 11 , , , cord-028721-x6f26ahr 348 12 followed follow VBN cord-028721-x6f26ahr 348 13 by by IN cord-028721-x6f26ahr 348 14 a a DT cord-028721-x6f26ahr 348 15 progressive progressive JJ cord-028721-x6f26ahr 348 16 increase increase NN cord-028721-x6f26ahr 348 17 to to IN cord-028721-x6f26ahr 348 18 100 100 CD cord-028721-x6f26ahr 348 19 % % NN cord-028721-x6f26ahr 348 20 at at IN cord-028721-x6f26ahr 348 21 puberty puberty NN cord-028721-x6f26ahr 348 22 . . . cord-028721-x6f26ahr 349 1 93 93 CD cord-028721-x6f26ahr 350 1 If if IN cord-028721-x6f26ahr 350 2 the the DT cord-028721-x6f26ahr 350 3 numbers number NNS cord-028721-x6f26ahr 350 4 of of IN cord-028721-x6f26ahr 350 5 gonocytes gonocyte NNS cord-028721-x6f26ahr 350 6 and and CC cord-028721-x6f26ahr 350 7 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 350 8 are be VBP cord-028721-x6f26ahr 350 9 calculated calculate VBN cord-028721-x6f26ahr 350 10 separately separately RB cord-028721-x6f26ahr 350 11 , , , cord-028721-x6f26ahr 350 12 it -PRON- PRP cord-028721-x6f26ahr 350 13 is be VBZ cord-028721-x6f26ahr 350 14 possible possible JJ cord-028721-x6f26ahr 350 15 to to TO cord-028721-x6f26ahr 350 16 determine determine VB cord-028721-x6f26ahr 350 17 when when WRB cord-028721-x6f26ahr 350 18 the the DT cord-028721-x6f26ahr 350 19 transformation transformation NN cord-028721-x6f26ahr 350 20 of of IN cord-028721-x6f26ahr 350 21 gonocytes gonocyte NNS cord-028721-x6f26ahr 350 22 to to IN cord-028721-x6f26ahr 350 23 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 350 24 occurs occur VBZ cord-028721-x6f26ahr 350 25 . . . cord-028721-x6f26ahr 351 1 The the DT cord-028721-x6f26ahr 351 2 most most RBS cord-028721-x6f26ahr 351 3 accurate accurate JJ cord-028721-x6f26ahr 351 4 measure measure NN cord-028721-x6f26ahr 351 5 is be VBZ cord-028721-x6f26ahr 351 6 calculation calculation NN cord-028721-x6f26ahr 351 7 of of IN cord-028721-x6f26ahr 351 8 total total JJ cord-028721-x6f26ahr 351 9 germ germ NN cord-028721-x6f26ahr 351 10 cell cell NN cord-028721-x6f26ahr 351 11 numbers number NNS cord-028721-x6f26ahr 351 12 per per IN cord-028721-x6f26ahr 351 13 testis testis NN cord-028721-x6f26ahr 351 14 . . . cord-028721-x6f26ahr 352 1 This this DT cord-028721-x6f26ahr 352 2 is be VBZ cord-028721-x6f26ahr 352 3 more more RBR cord-028721-x6f26ahr 352 4 diffi diffi JJ cord-028721-x6f26ahr 352 5 cult cult NN cord-028721-x6f26ahr 352 6 because because IN cord-028721-x6f26ahr 352 7 it -PRON- PRP cord-028721-x6f26ahr 352 8 requires require VBZ cord-028721-x6f26ahr 352 9 morphometric morphometric JJ cord-028721-x6f26ahr 352 10 assessment assessment NN cord-028721-x6f26ahr 352 11 of of IN cord-028721-x6f26ahr 352 12 intratubular intratubular JJ cord-028721-x6f26ahr 352 13 volume volume NN cord-028721-x6f26ahr 352 14 and and CC cord-028721-x6f26ahr 352 15 careful careful JJ cord-028721-x6f26ahr 352 16 clinical clinical JJ cord-028721-x6f26ahr 352 17 measurement measurement NN cord-028721-x6f26ahr 352 18 of of IN cord-028721-x6f26ahr 352 19 the the DT cord-028721-x6f26ahr 352 20 three three CD cord-028721-x6f26ahr 352 21 axes axis NNS cord-028721-x6f26ahr 352 22 of of IN cord-028721-x6f26ahr 352 23 the the DT cord-028721-x6f26ahr 352 24 testis testis NN cord-028721-x6f26ahr 352 25 . . . cord-028721-x6f26ahr 353 1 Congenital congenital JJ cord-028721-x6f26ahr 353 2 decrease decrease NN cord-028721-x6f26ahr 353 3 of of IN cord-028721-x6f26ahr 353 4 germ germ NN cord-028721-x6f26ahr 353 5 cells cell NNS cord-028721-x6f26ahr 353 6 occurs occur VBZ cord-028721-x6f26ahr 353 7 in in IN cord-028721-x6f26ahr 353 8 numerous numerous JJ cord-028721-x6f26ahr 353 9 conditions condition NNS cord-028721-x6f26ahr 353 10 , , , cord-028721-x6f26ahr 353 11 including include VBG cord-028721-x6f26ahr 353 12 trisomies trisomy NNS cord-028721-x6f26ahr 353 13 13 13 CD cord-028721-x6f26ahr 353 14 , , , cord-028721-x6f26ahr 353 15 18 18 CD cord-028721-x6f26ahr 353 16 , , , cord-028721-x6f26ahr 353 17 and and CC cord-028721-x6f26ahr 353 18 21 21 CD cord-028721-x6f26ahr 353 19 , , , cord-028721-x6f26ahr 353 20 some some DT cord-028721-x6f26ahr 353 21 forms form NNS cord-028721-x6f26ahr 353 22 of of IN cord-028721-x6f26ahr 353 23 primary primary JJ cord-028721-x6f26ahr 353 24 hypogonadism hypogonadism NN cord-028721-x6f26ahr 353 25 such such JJ cord-028721-x6f26ahr 353 26 as as IN cord-028721-x6f26ahr 353 27 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 353 28 's 's POS cord-028721-x6f26ahr 353 29 syndrome syndrome NN cord-028721-x6f26ahr 353 30 , , , cord-028721-x6f26ahr 353 31 anencephaly anencephaly NN cord-028721-x6f26ahr 353 32 , , , cord-028721-x6f26ahr 353 33 many many JJ cord-028721-x6f26ahr 353 34 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 353 35 testes testis NNS cord-028721-x6f26ahr 353 36 , , , cord-028721-x6f26ahr 353 37 and and CC cord-028721-x6f26ahr 353 38 in in IN cord-028721-x6f26ahr 353 39 patients patient NNS cord-028721-x6f26ahr 353 40 with with IN cord-028721-x6f26ahr 353 41 posterior posterior JJ cord-028721-x6f26ahr 353 42 urethral urethral JJ cord-028721-x6f26ahr 353 43 valves valve NNS cord-028721-x6f26ahr 353 44 and and CC cord-028721-x6f26ahr 353 45 severe severe JJ cord-028721-x6f26ahr 353 46 obstruction obstruction NN cord-028721-x6f26ahr 353 47 of of IN cord-028721-x6f26ahr 353 48 the the DT cord-028721-x6f26ahr 353 49 urinary urinary JJ cord-028721-x6f26ahr 353 50 ducts duct NNS cord-028721-x6f26ahr 353 51 . . . cord-028721-x6f26ahr 354 1 107 107 CD cord-028721-x6f26ahr 355 1 An an DT cord-028721-x6f26ahr 355 2 increased increase VBN cord-028721-x6f26ahr 355 3 number number NN cord-028721-x6f26ahr 355 4 of of IN cord-028721-x6f26ahr 355 5 germ germ NN cord-028721-x6f26ahr 355 6 cells cell NNS cord-028721-x6f26ahr 355 7 may may MD cord-028721-x6f26ahr 355 8 be be VB cord-028721-x6f26ahr 355 9 seen see VBN cord-028721-x6f26ahr 355 10 at at IN cord-028721-x6f26ahr 355 11 the the DT cord-028721-x6f26ahr 355 12 periphery periphery NN cord-028721-x6f26ahr 355 13 of of IN cord-028721-x6f26ahr 355 14 germ germ NN cord-028721-x6f26ahr 355 15 cell cell NN cord-028721-x6f26ahr 355 16 tumor tumor NN cord-028721-x6f26ahr 355 17 , , , cord-028721-x6f26ahr 355 18 gonadal gonadal JJ cord-028721-x6f26ahr 355 19 - - HYPH cord-028721-x6f26ahr 355 20 stromal stromal NN cord-028721-x6f26ahr 355 21 tumor tumor NN cord-028721-x6f26ahr 355 22 , , , cord-028721-x6f26ahr 355 23 and and CC cord-028721-x6f26ahr 355 24 paratesticular paratesticular JJ cord-028721-x6f26ahr 355 25 sarcoma sarcoma NN cord-028721-x6f26ahr 355 26 . . . cord-028721-x6f26ahr 356 1 At at IN cord-028721-x6f26ahr 356 2 the the DT cord-028721-x6f26ahr 356 3 periphery periphery NN cord-028721-x6f26ahr 356 4 of of IN cord-028721-x6f26ahr 356 5 Leydig Leydig NNP cord-028721-x6f26ahr 356 6 cell cell NN cord-028721-x6f26ahr 356 7 tumor tumor NN cord-028721-x6f26ahr 356 8 , , , cord-028721-x6f26ahr 356 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 356 10 tubular tubular JJ cord-028721-x6f26ahr 356 11 cellular cellular JJ cord-028721-x6f26ahr 356 12 maturation maturation NN cord-028721-x6f26ahr 356 13 may may MD cord-028721-x6f26ahr 356 14 be be VB cord-028721-x6f26ahr 356 15 complete complete JJ cord-028721-x6f26ahr 356 16 . . . cord-028721-x6f26ahr 357 1 Three three CD cord-028721-x6f26ahr 357 2 levels level NNS cord-028721-x6f26ahr 357 3 of of IN cord-028721-x6f26ahr 357 4 severity severity NN cord-028721-x6f26ahr 357 5 of of IN cord-028721-x6f26ahr 357 6 germinal germinal JJ cord-028721-x6f26ahr 357 7 hypoplasia hypoplasia NNS cord-028721-x6f26ahr 357 8 are be VBP cord-028721-x6f26ahr 357 9 recognized recognize VBN cord-028721-x6f26ahr 357 10 : : : cord-028721-x6f26ahr 357 11 slight slight JJ cord-028721-x6f26ahr 357 12 ( ( -LRB- cord-028721-x6f26ahr 357 13 tubular tubular JJ cord-028721-x6f26ahr 357 14 fertility fertility NN cord-028721-x6f26ahr 357 15 index index NN cord-028721-x6f26ahr 357 16 > > XX cord-028721-x6f26ahr 357 17 50 50 CD cord-028721-x6f26ahr 357 18 ) ) -RRB- cord-028721-x6f26ahr 357 19 , , , cord-028721-x6f26ahr 357 20 marked mark VBN cord-028721-x6f26ahr 357 21 ( ( -LRB- cord-028721-x6f26ahr 357 22 tubular tubular JJ cord-028721-x6f26ahr 357 23 fertility fertility NN cord-028721-x6f26ahr 357 24 index index NN cord-028721-x6f26ahr 357 25 between between IN cord-028721-x6f26ahr 357 26 50 50 CD cord-028721-x6f26ahr 357 27 and and CC cord-028721-x6f26ahr 357 28 30 30 CD cord-028721-x6f26ahr 357 29 ) ) -RRB- cord-028721-x6f26ahr 357 30 , , , cord-028721-x6f26ahr 357 31 and and CC cord-028721-x6f26ahr 357 32 severe severe JJ cord-028721-x6f26ahr 357 33 ( ( -LRB- cord-028721-x6f26ahr 357 34 tubular tubular JJ cord-028721-x6f26ahr 357 35 fertility fertility NN cord-028721-x6f26ahr 357 36 index index NN cord-028721-x6f26ahr 357 37 < < XX cord-028721-x6f26ahr 357 38 30 30 CD cord-028721-x6f26ahr 357 39 ) ) -RRB- cord-028721-x6f26ahr 358 1 ( ( -LRB- cord-028721-x6f26ahr 358 2 Fig Fig NNP cord-028721-x6f26ahr 358 3 . . . cord-028721-x6f26ahr 358 4 12 12 CD cord-028721-x6f26ahr 358 5 - - SYM cord-028721-x6f26ahr 358 6 17 17 CD cord-028721-x6f26ahr 358 7 ) ) -RRB- cord-028721-x6f26ahr 358 8 . . . cord-028721-x6f26ahr 359 1 Marked marked JJ cord-028721-x6f26ahr 359 2 and and CC cord-028721-x6f26ahr 359 3 severe severe JJ cord-028721-x6f26ahr 359 4 germinal germinal JJ cord-028721-x6f26ahr 359 5 hypoplasia hypoplasia NN cord-028721-x6f26ahr 359 6 is be VBZ cord-028721-x6f26ahr 359 7 usually usually RB cord-028721-x6f26ahr 359 8 associated associate VBN cord-028721-x6f26ahr 359 9 with with IN cord-028721-x6f26ahr 359 10 marked marked JJ cord-028721-x6f26ahr 359 11 or or CC cord-028721-x6f26ahr 359 12 severe severe JJ cord-028721-x6f26ahr 359 13 tubular tubular JJ cord-028721-x6f26ahr 359 14 hypoplasia hypoplasia NN cord-028721-x6f26ahr 359 15 , , , cord-028721-x6f26ahr 359 16 in in IN cord-028721-x6f26ahr 359 17 most most JJS cord-028721-x6f26ahr 359 18 cases case NNS cord-028721-x6f26ahr 359 19 resulting result VBG cord-028721-x6f26ahr 359 20 from from IN cord-028721-x6f26ahr 359 21 tubular tubular JJ cord-028721-x6f26ahr 359 22 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 359 23 . . . cord-028721-x6f26ahr 360 1 It -PRON- PRP cord-028721-x6f26ahr 360 2 also also RB cord-028721-x6f26ahr 360 3 is be VBZ cord-028721-x6f26ahr 360 4 useful useful JJ cord-028721-x6f26ahr 360 5 to to TO cord-028721-x6f26ahr 360 6 determine determine VB cord-028721-x6f26ahr 360 7 whether whether IN cord-028721-x6f26ahr 360 8 the the DT cord-028721-x6f26ahr 360 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 360 10 tubules tubule NNS cord-028721-x6f26ahr 360 11 devoid devoid JJ cord-028721-x6f26ahr 360 12 of of IN cord-028721-x6f26ahr 360 13 germ germ NN cord-028721-x6f26ahr 360 14 cells cell NNS cord-028721-x6f26ahr 360 15 are be VBP cord-028721-x6f26ahr 360 16 randomly randomly RB cord-028721-x6f26ahr 360 17 distributed distribute VBN cord-028721-x6f26ahr 360 18 . . . cord-028721-x6f26ahr 361 1 If if IN cord-028721-x6f26ahr 361 2 they -PRON- PRP cord-028721-x6f26ahr 361 3 are be VBP cord-028721-x6f26ahr 361 4 grouped group VBN cord-028721-x6f26ahr 361 5 , , , cord-028721-x6f26ahr 361 6 they -PRON- PRP cord-028721-x6f26ahr 361 7 probably probably RB cord-028721-x6f26ahr 361 8 belong belong VBP cord-028721-x6f26ahr 361 9 to to IN cord-028721-x6f26ahr 361 10 the the DT cord-028721-x6f26ahr 361 11 same same JJ cord-028721-x6f26ahr 361 12 lobule lobule NN cord-028721-x6f26ahr 361 13 or or CC cord-028721-x6f26ahr 361 14 group group NN cord-028721-x6f26ahr 361 15 of of IN cord-028721-x6f26ahr 361 16 lobules lobule NNS cord-028721-x6f26ahr 361 17 that that WDT cord-028721-x6f26ahr 361 18 never never RB cord-028721-x6f26ahr 361 19 will will MD cord-028721-x6f26ahr 361 20 develop develop VB cord-028721-x6f26ahr 361 21 normally normally RB cord-028721-x6f26ahr 361 22 . . . cord-028721-x6f26ahr 362 1 Other other JJ cord-028721-x6f26ahr 362 2 germ germ NN cord-028721-x6f26ahr 362 3 cells cell NNS cord-028721-x6f26ahr 362 4 observed observe VBN cord-028721-x6f26ahr 362 5 are be VBP cord-028721-x6f26ahr 362 6 multinucleate multinucleate JJ cord-028721-x6f26ahr 362 7 or or CC cord-028721-x6f26ahr 362 8 hypertrophied hypertrophied JJ cord-028721-x6f26ahr 362 9 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 362 10 and and CC cord-028721-x6f26ahr 362 11 gonocyte gonocyte NNP cord-028721-x6f26ahr 362 12 - - HYPH cord-028721-x6f26ahr 362 13 like like JJ cord-028721-x6f26ahr 362 14 cells cell NNS cord-028721-x6f26ahr 362 15 ; ; : cord-028721-x6f26ahr 362 16 these these DT cord-028721-x6f26ahr 362 17 latter latter RB cord-028721-x6f26ahr 362 18 may may MD cord-028721-x6f26ahr 362 19 require require VB cord-028721-x6f26ahr 362 20 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 362 21 studies study NNS cord-028721-x6f26ahr 362 22 to to TO cord-028721-x6f26ahr 362 23 exclude exclude VB cord-028721-x6f26ahr 362 24 intratubular intratubular JJ cord-028721-x6f26ahr 362 25 germ germ NN cord-028721-x6f26ahr 362 26 cell cell NN cord-028721-x6f26ahr 362 27 neoplasia neoplasia NN cord-028721-x6f26ahr 362 28 . . . cord-028721-x6f26ahr 363 1 The the DT cord-028721-x6f26ahr 363 2 number number NN cord-028721-x6f26ahr 363 3 of of IN cord-028721-x6f26ahr 363 4 Sertoli sertoli JJ cord-028721-x6f26ahr 363 5 cells cell NNS cord-028721-x6f26ahr 363 6 per per IN cord-028721-x6f26ahr 363 7 tubular tubular JJ cord-028721-x6f26ahr 363 8 cross cross JJ cord-028721-x6f26ahr 363 9 - - NN cord-028721-x6f26ahr 363 10 section section NN cord-028721-x6f26ahr 363 11 varies vary VBZ cord-028721-x6f26ahr 363 12 during during IN cord-028721-x6f26ahr 363 13 childhood childhood NN cord-028721-x6f26ahr 363 14 as as IN cord-028721-x6f26ahr 363 15 a a DT cord-028721-x6f26ahr 363 16 result result NN cord-028721-x6f26ahr 363 17 of of IN cord-028721-x6f26ahr 363 18 slow slow JJ cord-028721-x6f26ahr 363 19 proliferation proliferation NN cord-028721-x6f26ahr 363 20 from from IN cord-028721-x6f26ahr 363 21 4 4 CD cord-028721-x6f26ahr 363 22 years year NNS cord-028721-x6f26ahr 363 23 to to IN cord-028721-x6f26ahr 363 24 12 12 CD cord-028721-x6f26ahr 363 25 years year NNS cord-028721-x6f26ahr 363 26 108 108 CD cord-028721-x6f26ahr 363 27 and and CC cord-028721-x6f26ahr 363 28 the the DT cord-028721-x6f26ahr 363 29 redistribution redistribution NN cord-028721-x6f26ahr 363 30 of of IN cord-028721-x6f26ahr 363 31 Sertoli Sertoli NNP cord-028721-x6f26ahr 363 32 cells cell NNS cord-028721-x6f26ahr 363 33 as as IN cord-028721-x6f26ahr 363 34 the the DT cord-028721-x6f26ahr 363 35 seminiferous seminiferous JJ cord-028721-x6f26ahr 363 36 tubules tubule NNS cord-028721-x6f26ahr 363 37 become become VBP cord-028721-x6f26ahr 363 38 longer long RBR cord-028721-x6f26ahr 363 39 and and CC cord-028721-x6f26ahr 363 40 broader broad JJR cord-028721-x6f26ahr 363 41 . . . cord-028721-x6f26ahr 364 1 The the DT cord-028721-x6f26ahr 364 2 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 364 3 ed ed NN cord-028721-x6f26ahr 364 4 cellular cellular JJ cord-028721-x6f26ahr 364 5 pattern pattern NN cord-028721-x6f26ahr 364 6 characteristic characteristic NN cord-028721-x6f26ahr 364 7 of of IN cord-028721-x6f26ahr 364 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 364 9 cells cell NNS cord-028721-x6f26ahr 364 10 at at IN cord-028721-x6f26ahr 364 11 birth birth NN cord-028721-x6f26ahr 364 12 changes change NNS cord-028721-x6f26ahr 364 13 slowly slowly RB cord-028721-x6f26ahr 364 14 to to IN cord-028721-x6f26ahr 364 15 a a DT cord-028721-x6f26ahr 364 16 columnar columnar JJ cord-028721-x6f26ahr 364 17 pattern pattern NN cord-028721-x6f26ahr 364 18 at at IN cord-028721-x6f26ahr 364 19 puberty puberty NN cord-028721-x6f26ahr 364 20 . . . cord-028721-x6f26ahr 365 1 Testicular testicular JJ cord-028721-x6f26ahr 365 2 biopsies biopsy NNS cord-028721-x6f26ahr 365 3 may may MD cord-028721-x6f26ahr 365 4 reveal reveal VB cord-028721-x6f26ahr 365 5 hypoplasia hypoplasia NN cord-028721-x6f26ahr 365 6 or or CC cord-028721-x6f26ahr 365 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 365 8 of of IN cord-028721-x6f26ahr 365 9 Sertoli sertoli JJ cord-028721-x6f26ahr 365 10 cells cell NNS cord-028721-x6f26ahr 365 11 ; ; : cord-028721-x6f26ahr 365 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 365 13 is be VBZ cord-028721-x6f26ahr 365 14 usually usually RB cord-028721-x6f26ahr 365 15 pronounced pronounce VBN cord-028721-x6f26ahr 365 16 and and CC cord-028721-x6f26ahr 365 17 a a DT cord-028721-x6f26ahr 365 18 sign sign NN cord-028721-x6f26ahr 365 19 of of IN cord-028721-x6f26ahr 365 20 tubular tubular JJ cord-028721-x6f26ahr 365 21 dysgenesis dysgenesis NN cord-028721-x6f26ahr 365 22 , , , cord-028721-x6f26ahr 365 23 often often RB cord-028721-x6f26ahr 365 24 detected detect VBD cord-028721-x6f26ahr 365 25 during during IN cord-028721-x6f26ahr 365 26 the the DT cord-028721-x6f26ahr 365 27 fi fi NNP cord-028721-x6f26ahr 365 28 rst rst NN cord-028721-x6f26ahr 365 29 year year NN cord-028721-x6f26ahr 365 30 of of IN cord-028721-x6f26ahr 365 31 life life NN cord-028721-x6f26ahr 365 32 or or CC cord-028721-x6f26ahr 365 33 the the DT cord-028721-x6f26ahr 365 34 beginning beginning NN cord-028721-x6f26ahr 365 35 of of IN cord-028721-x6f26ahr 365 36 puberty puberty NN cord-028721-x6f26ahr 365 37 . . . cord-028721-x6f26ahr 366 1 109 109 CD cord-028721-x6f26ahr 367 1 Some some DT cord-028721-x6f26ahr 367 2 biopsies biopsy NNS cord-028721-x6f26ahr 367 3 reveal reveal VBP cord-028721-x6f26ahr 367 4 one one CD cord-028721-x6f26ahr 367 5 or or CC cord-028721-x6f26ahr 367 6 several several JJ cord-028721-x6f26ahr 367 7 tubular tubular JJ cord-028721-x6f26ahr 367 8 sections section NNS cord-028721-x6f26ahr 367 9 containing contain VBG cord-028721-x6f26ahr 367 10 Sertoli Sertoli NNP cord-028721-x6f26ahr 367 11 cells cell NNS cord-028721-x6f26ahr 367 12 with with IN cord-028721-x6f26ahr 367 13 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 367 14 and and CC cord-028721-x6f26ahr 367 15 granular granular JJ cord-028721-x6f26ahr 367 16 cytoplasm cytoplasm NN cord-028721-x6f26ahr 367 17 that that WDT cord-028721-x6f26ahr 367 18 is be VBZ cord-028721-x6f26ahr 367 19 positive positive JJ cord-028721-x6f26ahr 367 20 to to IN cord-028721-x6f26ahr 367 21 CD68 CD68 NNP cord-028721-x6f26ahr 367 22 and and CC cord-028721-x6f26ahr 367 23 α α NN cord-028721-x6f26ahr 367 24 1 1 CD cord-028721-x6f26ahr 367 25 -antitrypsin -antitrypsin CD cord-028721-x6f26ahr 367 26 . . . cord-028721-x6f26ahr 368 1 These these DT cord-028721-x6f26ahr 368 2 oncocytic oncocytic JJ cord-028721-x6f26ahr 368 3 changes change NNS cord-028721-x6f26ahr 368 4 are be VBP cord-028721-x6f26ahr 368 5 the the DT cord-028721-x6f26ahr 368 6 result result NN cord-028721-x6f26ahr 368 7 of of IN cord-028721-x6f26ahr 368 8 lysosomal lysosomal JJ cord-028721-x6f26ahr 368 9 accumulation accumulation NN cord-028721-x6f26ahr 368 10 . . . cord-028721-x6f26ahr 369 1 110 110 CD cord-028721-x6f26ahr 369 2 _SP cord-028721-x6f26ahr 369 3 Calculation Calculation NNP cord-028721-x6f26ahr 369 4 of of IN cord-028721-x6f26ahr 369 5 Leydig Leydig NNP cord-028721-x6f26ahr 369 6 cell cell NN cord-028721-x6f26ahr 369 7 numbers number NNS cord-028721-x6f26ahr 369 8 during during IN cord-028721-x6f26ahr 369 9 childhood childhood NN cord-028721-x6f26ahr 369 10 is be VBZ cord-028721-x6f26ahr 369 11 diffi diffi JJ cord-028721-x6f26ahr 369 12 cult cult NN cord-028721-x6f26ahr 369 13 because because IN cord-028721-x6f26ahr 369 14 at at IN cord-028721-x6f26ahr 369 15 this this DT cord-028721-x6f26ahr 369 16 age age NN cord-028721-x6f26ahr 369 17 the the DT cord-028721-x6f26ahr 369 18 population population NN cord-028721-x6f26ahr 369 19 is be VBZ cord-028721-x6f26ahr 369 20 scant scant JJ cord-028721-x6f26ahr 369 21 . . . cord-028721-x6f26ahr 370 1 102 102 CD cord-028721-x6f26ahr 370 2 Semi semi JJ cord-028721-x6f26ahr 370 3 - - JJ cord-028721-x6f26ahr 370 4 thin thin JJ cord-028721-x6f26ahr 370 5 sections section NNS cord-028721-x6f26ahr 370 6 or or CC cord-028721-x6f26ahr 370 7 immunohistochemistry immunohistochemistry JJ cord-028721-x6f26ahr 370 8 to to TO cord-028721-x6f26ahr 370 9 detect detect VB cord-028721-x6f26ahr 370 10 testosteronecontaining testosteronecontaining NN cord-028721-x6f26ahr 370 11 cells cell NNS cord-028721-x6f26ahr 370 12 may may MD cord-028721-x6f26ahr 370 13 be be VB cord-028721-x6f26ahr 370 14 helpful helpful JJ cord-028721-x6f26ahr 370 15 . . . cord-028721-x6f26ahr 371 1 111 111 CD cord-028721-x6f26ahr 371 2 Selection selection NN cord-028721-x6f26ahr 371 3 of of IN cord-028721-x6f26ahr 371 4 the the DT cord-028721-x6f26ahr 371 5 appropriate appropriate JJ cord-028721-x6f26ahr 371 6 denominator denominator NN cord-028721-x6f26ahr 371 7 to to TO cord-028721-x6f26ahr 371 8 express express VB cord-028721-x6f26ahr 371 9 the the DT cord-028721-x6f26ahr 371 10 Leydig Leydig NNP cord-028721-x6f26ahr 371 11 cell cell NN cord-028721-x6f26ahr 371 12 population population NN cord-028721-x6f26ahr 371 13 is be VBZ cord-028721-x6f26ahr 371 14 another another DT cord-028721-x6f26ahr 371 15 problem problem NN cord-028721-x6f26ahr 371 16 . . . cord-028721-x6f26ahr 372 1 The the DT cord-028721-x6f26ahr 372 2 most most RBS cord-028721-x6f26ahr 372 3 frequent frequent JJ cord-028721-x6f26ahr 372 4 measures measure NNS cord-028721-x6f26ahr 372 5 are be VBP cord-028721-x6f26ahr 372 6 Leydig leydig NN cord-028721-x6f26ahr 372 7 cell cell NN cord-028721-x6f26ahr 372 8 number number NN cord-028721-x6f26ahr 372 9 per per IN cord-028721-x6f26ahr 372 10 tubular tubular JJ cord-028721-x6f26ahr 372 11 section section NN cord-028721-x6f26ahr 372 12 , , , cord-028721-x6f26ahr 372 13 per per IN cord-028721-x6f26ahr 372 14 unit unit NN cord-028721-x6f26ahr 372 15 area area NN cord-028721-x6f26ahr 372 16 , , , cord-028721-x6f26ahr 372 17 or or CC cord-028721-x6f26ahr 372 18 total total JJ cord-028721-x6f26ahr 372 19 number number NN cord-028721-x6f26ahr 372 20 per per IN cord-028721-x6f26ahr 372 21 testis testis NN cord-028721-x6f26ahr 372 22 . . . cord-028721-x6f26ahr 373 1 104 104 CD cord-028721-x6f26ahr 373 2 Low low JJ cord-028721-x6f26ahr 373 3 numbers number NNS cord-028721-x6f26ahr 373 4 of of IN cord-028721-x6f26ahr 373 5 Leydig Leydig NNP cord-028721-x6f26ahr 373 6 cell cell NN cord-028721-x6f26ahr 373 7 are be VBP cord-028721-x6f26ahr 373 8 observed observe VBN cord-028721-x6f26ahr 373 9 in in IN cord-028721-x6f26ahr 373 10 undescended undescended JJ cord-028721-x6f26ahr 373 11 testes testis NNS cord-028721-x6f26ahr 373 12 , , , cord-028721-x6f26ahr 373 13 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 373 14 hypogonadism hypogonadism NN cord-028721-x6f26ahr 373 15 , , , cord-028721-x6f26ahr 373 16 some some DT cord-028721-x6f26ahr 373 17 variants variant NNS cord-028721-x6f26ahr 373 18 of of IN cord-028721-x6f26ahr 373 19 male male JJ cord-028721-x6f26ahr 373 20 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 373 21 caused cause VBN cord-028721-x6f26ahr 373 22 by by IN cord-028721-x6f26ahr 373 23 a a DT cord-028721-x6f26ahr 373 24 defect defect NN cord-028721-x6f26ahr 373 25 in in IN cord-028721-x6f26ahr 373 26 the the DT cord-028721-x6f26ahr 373 27 LH LH NNP cord-028721-x6f26ahr 373 28 receptor receptor NN cord-028721-x6f26ahr 373 29 , , , cord-028721-x6f26ahr 373 30 and and CC cord-028721-x6f26ahr 373 31 in in IN cord-028721-x6f26ahr 373 32 anencephalic anencephalic JJ cord-028721-x6f26ahr 373 33 fetuses fetus NNS cord-028721-x6f26ahr 373 34 . . . cord-028721-x6f26ahr 374 1 High high JJ cord-028721-x6f26ahr 374 2 numbers number NNS cord-028721-x6f26ahr 374 3 of of IN cord-028721-x6f26ahr 374 4 Leydig leydig NN cord-028721-x6f26ahr 374 5 cells cell NNS cord-028721-x6f26ahr 374 6 occur occur VBP cord-028721-x6f26ahr 374 7 in in IN cord-028721-x6f26ahr 374 8 congenital congenital JJ cord-028721-x6f26ahr 374 9 Leydig Leydig NNP cord-028721-x6f26ahr 374 10 cell cell NN cord-028721-x6f26ahr 374 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 374 12 , , , cord-028721-x6f26ahr 374 13 112 112 CD cord-028721-x6f26ahr 374 14 triploid triploid JJ cord-028721-x6f26ahr 374 15 fetuses fetus NNS cord-028721-x6f26ahr 374 16 , , , cord-028721-x6f26ahr 374 17 113 113 CD cord-028721-x6f26ahr 374 18 variants variant NNS cord-028721-x6f26ahr 374 19 of of IN cord-028721-x6f26ahr 374 20 precocious precocious JJ cord-028721-x6f26ahr 374 21 puberty puberty NN cord-028721-x6f26ahr 374 22 , , , cord-028721-x6f26ahr 374 23 several several JJ cord-028721-x6f26ahr 374 24 syndromes syndrome NNS cord-028721-x6f26ahr 374 25 such such JJ cord-028721-x6f26ahr 374 26 as as IN cord-028721-x6f26ahr 374 27 leprechaunism leprechaunism NN cord-028721-x6f26ahr 374 28 and and CC cord-028721-x6f26ahr 374 29 Beckwith Beckwith NNP cord-028721-x6f26ahr 374 30 - - HYPH cord-028721-x6f26ahr 374 31 Wiederman Wiederman NNP cord-028721-x6f26ahr 374 32 syndrome syndrome NN cord-028721-x6f26ahr 374 33 , , , cord-028721-x6f26ahr 374 34 and and CC cord-028721-x6f26ahr 374 35 in in IN cord-028721-x6f26ahr 374 36 most most JJS cord-028721-x6f26ahr 374 37 male male JJ cord-028721-x6f26ahr 374 38 pseudohermaphroditisms pseudohermaphroditism NNS cord-028721-x6f26ahr 374 39 . . . cord-028721-x6f26ahr 375 1 An an DT cord-028721-x6f26ahr 375 2 apparent apparent JJ cord-028721-x6f26ahr 375 3 increase increase NN cord-028721-x6f26ahr 375 4 in in IN cord-028721-x6f26ahr 375 5 loose loose JJ cord-028721-x6f26ahr 375 6 connective connective JJ cord-028721-x6f26ahr 375 7 tissue tissue NN cord-028721-x6f26ahr 375 8 is be VBZ cord-028721-x6f26ahr 375 9 found find VBN cord-028721-x6f26ahr 375 10 in in IN cord-028721-x6f26ahr 375 11 patients patient NNS cord-028721-x6f26ahr 375 12 with with IN cord-028721-x6f26ahr 375 13 marked marked JJ cord-028721-x6f26ahr 375 14 tubular tubular JJ cord-028721-x6f26ahr 375 15 hypoplasia hypoplasia NN cord-028721-x6f26ahr 375 16 ; ; : cord-028721-x6f26ahr 375 17 in in IN cord-028721-x6f26ahr 375 18 addition addition NN cord-028721-x6f26ahr 375 19 , , , cord-028721-x6f26ahr 375 20 disordered disordered JJ cord-028721-x6f26ahr 375 21 thick thick JJ cord-028721-x6f26ahr 375 22 fusiform fusiform JJ cord-028721-x6f26ahr 375 23 cell cell NN cord-028721-x6f26ahr 375 24 bundles bundle NNS cord-028721-x6f26ahr 375 25 are be VBP cord-028721-x6f26ahr 375 26 seen see VBN cord-028721-x6f26ahr 375 27 in in IN cord-028721-x6f26ahr 375 28 patients patient NNS cord-028721-x6f26ahr 375 29 with with IN cord-028721-x6f26ahr 375 30 androgen androgen NN cord-028721-x6f26ahr 375 31 insensitivity insensitivity NN cord-028721-x6f26ahr 375 32 . . . cord-028721-x6f26ahr 376 1 Other other JJ cord-028721-x6f26ahr 376 2 alterations alteration NNS cord-028721-x6f26ahr 376 3 include include VBP cord-028721-x6f26ahr 376 4 the the DT cord-028721-x6f26ahr 376 5 presence presence NN cord-028721-x6f26ahr 376 6 of of IN cord-028721-x6f26ahr 376 7 excessively excessively RB cord-028721-x6f26ahr 376 8 developed develop VBN cord-028721-x6f26ahr 376 9 lymphatic lymphatic JJ cord-028721-x6f26ahr 376 10 vessels vessel NNS cord-028721-x6f26ahr 376 11 ( ( -LRB- cord-028721-x6f26ahr 376 12 lymphangiectasis lymphangiectasis NNP cord-028721-x6f26ahr 376 13 ) ) -RRB- cord-028721-x6f26ahr 376 14 , , , cord-028721-x6f26ahr 376 15 focal focal JJ cord-028721-x6f26ahr 376 16 hematopoiesis hematopoiesis NN cord-028721-x6f26ahr 376 17 , , , cord-028721-x6f26ahr 376 18 leukemic leukemic JJ cord-028721-x6f26ahr 376 19 infi infi NNP cord-028721-x6f26ahr 376 20 ltration ltration NNP cord-028721-x6f26ahr 376 21 , , , cord-028721-x6f26ahr 376 22 and and CC cord-028721-x6f26ahr 376 23 the the DT cord-028721-x6f26ahr 376 24 presence presence NN cord-028721-x6f26ahr 376 25 of of IN cord-028721-x6f26ahr 376 26 cells cell NNS cord-028721-x6f26ahr 376 27 similar similar JJ cord-028721-x6f26ahr 376 28 to to IN cord-028721-x6f26ahr 376 29 those those DT cord-028721-x6f26ahr 376 30 of of IN cord-028721-x6f26ahr 376 31 the the DT cord-028721-x6f26ahr 376 32 adrenal adrenal JJ cord-028721-x6f26ahr 376 33 cortex cortex NN cord-028721-x6f26ahr 376 34 ( ( -LRB- cord-028721-x6f26ahr 376 35 tumors tumor NNS cord-028721-x6f26ahr 376 36 of of IN cord-028721-x6f26ahr 376 37 the the DT cord-028721-x6f26ahr 376 38 adrenogenital adrenogenital NNP cord-028721-x6f26ahr 376 39 syndrome syndrome NN cord-028721-x6f26ahr 376 40 ) ) -RRB- cord-028721-x6f26ahr 376 41 . . . cord-028721-x6f26ahr 377 1 Embryology embryology NN cord-028721-x6f26ahr 377 2 and and CC cord-028721-x6f26ahr 377 3 anatomy anatomy NN cord-028721-x6f26ahr 377 4 of of IN cord-028721-x6f26ahr 377 5 the the DT cord-028721-x6f26ahr 377 6 testis testis NN cord-028721-x6f26ahr 377 7 _SP cord-028721-x6f26ahr 378 1 The the DT cord-028721-x6f26ahr 378 2 adult adult NN cord-028721-x6f26ahr 378 3 testis testis NN cord-028721-x6f26ahr 378 4 is be VBZ cord-028721-x6f26ahr 378 5 an an DT cord-028721-x6f26ahr 378 6 egg egg NN cord-028721-x6f26ahr 378 7 - - HYPH cord-028721-x6f26ahr 378 8 shaped shape VBN cord-028721-x6f26ahr 378 9 organ organ NN cord-028721-x6f26ahr 378 10 that that WDT cord-028721-x6f26ahr 378 11 hangs hang VBZ cord-028721-x6f26ahr 378 12 in in IN cord-028721-x6f26ahr 378 13 the the DT cord-028721-x6f26ahr 378 14 scrotum scrotum NN cord-028721-x6f26ahr 378 15 from from IN cord-028721-x6f26ahr 378 16 the the DT cord-028721-x6f26ahr 378 17 spermatic spermatic JJ cord-028721-x6f26ahr 378 18 cord cord NN cord-028721-x6f26ahr 378 19 , , , cord-028721-x6f26ahr 378 20 the the DT cord-028721-x6f26ahr 378 21 retroepididymal retroepididymal NN cord-028721-x6f26ahr 378 22 surface surface NN cord-028721-x6f26ahr 378 23 , , , cord-028721-x6f26ahr 378 24 and and CC cord-028721-x6f26ahr 378 25 the the DT cord-028721-x6f26ahr 378 26 scrotal scrotal JJ cord-028721-x6f26ahr 378 27 ligament ligament NN cord-028721-x6f26ahr 378 28 . . . cord-028721-x6f26ahr 379 1 Mean mean JJ cord-028721-x6f26ahr 379 2 weight weight NN cord-028721-x6f26ahr 379 3 in in IN cord-028721-x6f26ahr 379 4 Caucasian caucasian JJ cord-028721-x6f26ahr 379 5 men man NNS cord-028721-x6f26ahr 379 6 is be VBZ cord-028721-x6f26ahr 379 7 21.6 21.6 CD cord-028721-x6f26ahr 379 8 ± ± CD cord-028721-x6f26ahr 379 9 0.4 0.4 CD cord-028721-x6f26ahr 379 10 g g NN cord-028721-x6f26ahr 379 11 for for IN cord-028721-x6f26ahr 379 12 the the DT cord-028721-x6f26ahr 379 13 right right JJ cord-028721-x6f26ahr 379 14 testis testis NN cord-028721-x6f26ahr 379 15 and and CC cord-028721-x6f26ahr 379 16 20 20 CD cord-028721-x6f26ahr 379 17 ± ± NNP cord-028721-x6f26ahr 379 18 0.4 0.4 CD cord-028721-x6f26ahr 379 19 g g NN cord-028721-x6f26ahr 379 20 for for IN cord-028721-x6f26ahr 379 21 the the DT cord-028721-x6f26ahr 379 22 left left NN cord-028721-x6f26ahr 379 23 . . . cord-028721-x6f26ahr 380 1 Mean mean JJ cord-028721-x6f26ahr 380 2 testicular testicular JJ cord-028721-x6f26ahr 380 3 diameter diameter NN cord-028721-x6f26ahr 380 4 is be VBZ cord-028721-x6f26ahr 380 5 4.6 4.6 CD cord-028721-x6f26ahr 380 6 cm cm NNS cord-028721-x6f26ahr 380 7 ( ( -LRB- cord-028721-x6f26ahr 380 8 range range NN cord-028721-x6f26ahr 380 9 , , , cord-028721-x6f26ahr 380 10 3.6 3.6 CD cord-028721-x6f26ahr 380 11 - - SYM cord-028721-x6f26ahr 380 12 5.5 5.5 CD cord-028721-x6f26ahr 380 13 cm cm NNS cord-028721-x6f26ahr 380 14 ) ) -RRB- cord-028721-x6f26ahr 380 15 for for IN cord-028721-x6f26ahr 380 16 the the DT cord-028721-x6f26ahr 380 17 longest long JJS cord-028721-x6f26ahr 380 18 axis axis NN cord-028721-x6f26ahr 380 19 and and CC cord-028721-x6f26ahr 380 20 2.6 2.6 CD cord-028721-x6f26ahr 380 21 cm cm NNS cord-028721-x6f26ahr 380 22 ( ( -LRB- cord-028721-x6f26ahr 380 23 range range NN cord-028721-x6f26ahr 380 24 , , , cord-028721-x6f26ahr 380 25 2.1 2.1 CD cord-028721-x6f26ahr 380 26 - - SYM cord-028721-x6f26ahr 380 27 3.2 3.2 CD cord-028721-x6f26ahr 380 28 cm cm NNS cord-028721-x6f26ahr 380 29 ) ) -RRB- cord-028721-x6f26ahr 380 30 for for IN cord-028721-x6f26ahr 380 31 the the DT cord-028721-x6f26ahr 380 32 shortest short JJS cord-028721-x6f26ahr 380 33 . . . cord-028721-x6f26ahr 381 1 [ [ -LRB- cord-028721-x6f26ahr 381 2 114 114 CD cord-028721-x6f26ahr 381 3 ] ] -RRB- cord-028721-x6f26ahr 381 4 [ [ -LRB- cord-028721-x6f26ahr 381 5 115 115 CD cord-028721-x6f26ahr 381 6 ] ] -RRB- cord-028721-x6f26ahr 381 7 [ [ -LRB- cord-028721-x6f26ahr 381 8 116 116 CD cord-028721-x6f26ahr 381 9 ] ] -RRB- cord-028721-x6f26ahr 381 10 [ [ -LRB- cord-028721-x6f26ahr 381 11 117 117 CD cord-028721-x6f26ahr 381 12 ] ] -RRB- cord-028721-x6f26ahr 381 13 Testicular testicular JJ cord-028721-x6f26ahr 381 14 volume volume NN cord-028721-x6f26ahr 381 15 varies vary VBZ cord-028721-x6f26ahr 381 16 from from IN cord-028721-x6f26ahr 381 17 15 15 CD cord-028721-x6f26ahr 381 18 to to TO cord-028721-x6f26ahr 381 19 25 25 CD cord-028721-x6f26ahr 381 20 mL. mL. NNS cord-028721-x6f26ahr 381 21 The the DT cord-028721-x6f26ahr 381 22 tunica tunica NNP cord-028721-x6f26ahr 381 23 albuginea albuginea NNP cord-028721-x6f26ahr 381 24 and and CC cord-028721-x6f26ahr 381 25 interlobular interlobular NNP cord-028721-x6f26ahr 381 26 septa septa NNP cord-028721-x6f26ahr 381 27 make make VBP cord-028721-x6f26ahr 381 28 up up RP cord-028721-x6f26ahr 381 29 the the DT cord-028721-x6f26ahr 381 30 connective connective JJ cord-028721-x6f26ahr 381 31 tissue tissue NN cord-028721-x6f26ahr 381 32 framework framework NN cord-028721-x6f26ahr 381 33 of of IN cord-028721-x6f26ahr 381 34 the the DT cord-028721-x6f26ahr 381 35 testis testis NN cord-028721-x6f26ahr 381 36 . . . cord-028721-x6f26ahr 382 1 The the DT cord-028721-x6f26ahr 382 2 tunica tunica NNP cord-028721-x6f26ahr 382 3 albuginea albuginea NNP cord-028721-x6f26ahr 382 4 consists consist VBZ cord-028721-x6f26ahr 382 5 of of IN cord-028721-x6f26ahr 382 6 three three CD cord-028721-x6f26ahr 382 7 connective connective JJ cord-028721-x6f26ahr 382 8 tissue tissue NN cord-028721-x6f26ahr 382 9 layers layer NNS cord-028721-x6f26ahr 382 10 and and CC cord-028721-x6f26ahr 382 11 an an DT cord-028721-x6f26ahr 382 12 outer outer JJ cord-028721-x6f26ahr 382 13 surface surface NN cord-028721-x6f26ahr 382 14 covered cover VBN cord-028721-x6f26ahr 382 15 by by IN cord-028721-x6f26ahr 382 16 mesothelium mesothelium NNP cord-028721-x6f26ahr 382 17 . . . cord-028721-x6f26ahr 383 1 From from IN cord-028721-x6f26ahr 383 2 the the DT cord-028721-x6f26ahr 383 3 outer outer NN cord-028721-x6f26ahr 383 4 to to IN cord-028721-x6f26ahr 383 5 the the DT cord-028721-x6f26ahr 383 6 inner inner JJ cord-028721-x6f26ahr 383 7 layers layer NNS cord-028721-x6f26ahr 383 8 , , , cord-028721-x6f26ahr 383 9 the the DT cord-028721-x6f26ahr 383 10 amount amount NN cord-028721-x6f26ahr 383 11 of of IN cord-028721-x6f26ahr 383 12 collagen collagen NN cord-028721-x6f26ahr 383 13 fi fi NN cord-028721-x6f26ahr 383 14 bers ber NNS cord-028721-x6f26ahr 383 15 decreases decrease VBZ cord-028721-x6f26ahr 383 16 while while IN cord-028721-x6f26ahr 383 17 the the DT cord-028721-x6f26ahr 383 18 number number NN cord-028721-x6f26ahr 383 19 of of IN cord-028721-x6f26ahr 383 20 cells cell NNS cord-028721-x6f26ahr 383 21 increases increase NNS cord-028721-x6f26ahr 383 22 . . . cord-028721-x6f26ahr 384 1 The the DT cord-028721-x6f26ahr 384 2 fi fi NN cord-028721-x6f26ahr 384 3 bers ber NNS cord-028721-x6f26ahr 384 4 and and CC cord-028721-x6f26ahr 384 5 cells cell NNS cord-028721-x6f26ahr 384 6 in in IN cord-028721-x6f26ahr 384 7 the the DT cord-028721-x6f26ahr 384 8 two two CD cord-028721-x6f26ahr 384 9 outermost outermost JJ cord-028721-x6f26ahr 384 10 layers layer NNS cord-028721-x6f26ahr 384 11 form form VBP cord-028721-x6f26ahr 384 12 planes plane NNS cord-028721-x6f26ahr 384 13 parallel parallel JJ cord-028721-x6f26ahr 384 14 to to IN cord-028721-x6f26ahr 384 15 the the DT cord-028721-x6f26ahr 384 16 testicular testicular NN cord-028721-x6f26ahr 384 17 surface surface NN cord-028721-x6f26ahr 384 18 ; ; : cord-028721-x6f26ahr 384 19 cell cell NN cord-028721-x6f26ahr 384 20 types type NNS cord-028721-x6f26ahr 384 21 include include VBP cord-028721-x6f26ahr 384 22 fi fi NNP cord-028721-x6f26ahr 384 23 broblasts broblasts NNP cord-028721-x6f26ahr 384 24 , , , cord-028721-x6f26ahr 384 25 myofi myofi NNP cord-028721-x6f26ahr 384 26 broblasts broblasts NNP cord-028721-x6f26ahr 384 27 , , , cord-028721-x6f26ahr 384 28 and and CC cord-028721-x6f26ahr 384 29 mast mast NN cord-028721-x6f26ahr 384 30 cells cell NNS cord-028721-x6f26ahr 384 31 . . . cord-028721-x6f26ahr 385 1 Myofi Myofi NNP cord-028721-x6f26ahr 385 2 broblasts broblast NNS cord-028721-x6f26ahr 385 3 are be VBP cord-028721-x6f26ahr 385 4 more more RBR cord-028721-x6f26ahr 385 5 numerous numerous JJ cord-028721-x6f26ahr 385 6 in in IN cord-028721-x6f26ahr 385 7 the the DT cord-028721-x6f26ahr 385 8 posterior posterior JJ cord-028721-x6f26ahr 385 9 portion portion NN cord-028721-x6f26ahr 385 10 of of IN cord-028721-x6f26ahr 385 11 the the DT cord-028721-x6f26ahr 385 12 testis testis NN cord-028721-x6f26ahr 385 13 . . . cord-028721-x6f26ahr 386 1 The the DT cord-028721-x6f26ahr 386 2 thickness thickness NN cord-028721-x6f26ahr 386 3 of of IN cord-028721-x6f26ahr 386 4 the the DT cord-028721-x6f26ahr 386 5 tunica tunica NNP cord-028721-x6f26ahr 386 6 albuginea albuginea NNP cord-028721-x6f26ahr 386 7 increases increase VBZ cord-028721-x6f26ahr 386 8 with with IN cord-028721-x6f26ahr 386 9 age age NN cord-028721-x6f26ahr 386 10 from from IN cord-028721-x6f26ahr 386 11 400 400 CD cord-028721-x6f26ahr 386 12 - - SYM cord-028721-x6f26ahr 386 13 450 450 CD cord-028721-x6f26ahr 386 14 µm µm NN cord-028721-x6f26ahr 386 15 in in IN cord-028721-x6f26ahr 386 16 young young JJ cord-028721-x6f26ahr 386 17 men man NNS cord-028721-x6f26ahr 386 18 to to IN cord-028721-x6f26ahr 386 19 more more JJR cord-028721-x6f26ahr 386 20 than than IN cord-028721-x6f26ahr 386 21 900 900 CD cord-028721-x6f26ahr 386 22 µm µm NN cord-028721-x6f26ahr 386 23 in in IN cord-028721-x6f26ahr 386 24 elderly elderly JJ cord-028721-x6f26ahr 386 25 men man NNS cord-028721-x6f26ahr 386 26 . . . cord-028721-x6f26ahr 387 1 118 118 CD cord-028721-x6f26ahr 388 1 It -PRON- PRP cord-028721-x6f26ahr 388 2 acts act VBZ cord-028721-x6f26ahr 388 3 as as IN cord-028721-x6f26ahr 388 4 a a DT cord-028721-x6f26ahr 388 5 semipermeable semipermeable JJ cord-028721-x6f26ahr 388 6 membrane membrane NN cord-028721-x6f26ahr 388 7 that that WDT cord-028721-x6f26ahr 388 8 produces produce VBZ cord-028721-x6f26ahr 388 9 the the DT cord-028721-x6f26ahr 388 10 fl fl NNP cord-028721-x6f26ahr 388 11 uid uid NN cord-028721-x6f26ahr 388 12 of of IN cord-028721-x6f26ahr 388 13 the the DT cord-028721-x6f26ahr 388 14 vaginal vaginal JJ cord-028721-x6f26ahr 388 15 cavity cavity NN cord-028721-x6f26ahr 388 16 . . . cord-028721-x6f26ahr 389 1 The the DT cord-028721-x6f26ahr 389 2 presence presence NN cord-028721-x6f26ahr 389 3 of of IN cord-028721-x6f26ahr 389 4 many many JJ cord-028721-x6f26ahr 389 5 contractile contractile JJ cord-028721-x6f26ahr 389 6 cells cell NNS cord-028721-x6f26ahr 389 7 showing show VBG cord-028721-x6f26ahr 389 8 high high JJ cord-028721-x6f26ahr 389 9 concentrations concentration NNS cord-028721-x6f26ahr 389 10 of of IN cord-028721-x6f26ahr 389 11 GMP GMP NNP cord-028721-x6f26ahr 389 12 suggests suggest VBZ cord-028721-x6f26ahr 389 13 that that IN cord-028721-x6f26ahr 389 14 the the DT cord-028721-x6f26ahr 389 15 tunica tunica NNP cord-028721-x6f26ahr 389 16 albuginea albuginea NNP cord-028721-x6f26ahr 389 17 undergoes undergo VBZ cord-028721-x6f26ahr 389 18 impulses impulse NNS cord-028721-x6f26ahr 389 19 of of IN cord-028721-x6f26ahr 389 20 contraction contraction NN cord-028721-x6f26ahr 389 21 and and CC cord-028721-x6f26ahr 389 22 relaxation relaxation NN cord-028721-x6f26ahr 389 23 . . . cord-028721-x6f26ahr 390 1 These these DT cord-028721-x6f26ahr 390 2 cells cell NNS cord-028721-x6f26ahr 390 3 might may MD cord-028721-x6f26ahr 390 4 regulate regulate VB cord-028721-x6f26ahr 390 5 testicular testicular JJ cord-028721-x6f26ahr 390 6 size size NN cord-028721-x6f26ahr 390 7 119 119 CD cord-028721-x6f26ahr 390 8 and and CC cord-028721-x6f26ahr 390 9 favor favor VB cord-028721-x6f26ahr 390 10 the the DT cord-028721-x6f26ahr 390 11 transport transport NN cord-028721-x6f26ahr 390 12 of of IN cord-028721-x6f26ahr 390 13 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 390 14 into into IN cord-028721-x6f26ahr 390 15 the the DT cord-028721-x6f26ahr 390 16 epididymis epididymis NN cord-028721-x6f26ahr 390 17 . . . cord-028721-x6f26ahr 391 1 120 120 CD cord-028721-x6f26ahr 392 1 The the DT cord-028721-x6f26ahr 392 2 innermost innermost JJ cord-028721-x6f26ahr 392 3 layer layer NN cord-028721-x6f26ahr 392 4 , , , cord-028721-x6f26ahr 392 5 the the DT cord-028721-x6f26ahr 392 6 tunica tunica NNP cord-028721-x6f26ahr 392 7 vasculosa vasculosa NNP cord-028721-x6f26ahr 392 8 , , , cord-028721-x6f26ahr 392 9 consists consist VBZ cord-028721-x6f26ahr 392 10 of of IN cord-028721-x6f26ahr 392 11 loose loose JJ cord-028721-x6f26ahr 392 12 connective connective JJ cord-028721-x6f26ahr 392 13 tissue tissue NN cord-028721-x6f26ahr 392 14 containing contain VBG cord-028721-x6f26ahr 392 15 blood blood NN cord-028721-x6f26ahr 392 16 and and CC cord-028721-x6f26ahr 392 17 lymphatic lymphatic NN cord-028721-x6f26ahr 392 18 vessels vessel NNS cord-028721-x6f26ahr 392 19 . . . cord-028721-x6f26ahr 393 1 The the DT cord-028721-x6f26ahr 393 2 interlobular interlobular JJ cord-028721-x6f26ahr 393 3 septa septa NN cord-028721-x6f26ahr 393 4 consist consist VBP cord-028721-x6f26ahr 393 5 of of IN cord-028721-x6f26ahr 393 6 fi fi NNP cord-028721-x6f26ahr 393 7 brous brous JJ cord-028721-x6f26ahr 393 8 connective connective JJ cord-028721-x6f26ahr 393 9 tissue tissue NN cord-028721-x6f26ahr 393 10 with with IN cord-028721-x6f26ahr 393 11 blood blood NN cord-028721-x6f26ahr 393 12 vessels vessel NNS cord-028721-x6f26ahr 393 13 supplying supply VBG cord-028721-x6f26ahr 393 14 the the DT cord-028721-x6f26ahr 393 15 testicular testicular JJ cord-028721-x6f26ahr 393 16 parenchyma parenchyma NN cord-028721-x6f26ahr 393 17 . . . cord-028721-x6f26ahr 394 1 The the DT cord-028721-x6f26ahr 394 2 interlobular interlobular JJ cord-028721-x6f26ahr 394 3 septa septa NN cord-028721-x6f26ahr 394 4 divide divide VBP cord-028721-x6f26ahr 394 5 the the DT cord-028721-x6f26ahr 394 6 testis testis NN cord-028721-x6f26ahr 394 7 into into IN cord-028721-x6f26ahr 394 8 approximately approximately RB cord-028721-x6f26ahr 394 9 250 250 CD cord-028721-x6f26ahr 394 10 pyramidal pyramidal JJ cord-028721-x6f26ahr 394 11 lobules lobule NNS cord-028721-x6f26ahr 394 12 with with IN cord-028721-x6f26ahr 394 13 their -PRON- PRP$ cord-028721-x6f26ahr 394 14 bases basis NNS cord-028721-x6f26ahr 394 15 at at IN cord-028721-x6f26ahr 394 16 the the DT cord-028721-x6f26ahr 394 17 tunica tunica NNP cord-028721-x6f26ahr 394 18 albuginea albuginea NNP cord-028721-x6f26ahr 394 19 and and CC cord-028721-x6f26ahr 394 20 vertices vertex NNS cord-028721-x6f26ahr 394 21 at at IN cord-028721-x6f26ahr 394 22 the the DT cord-028721-x6f26ahr 394 23 mediastinum mediastinum NNP cord-028721-x6f26ahr 394 24 testis testis NN cord-028721-x6f26ahr 394 25 . . . cord-028721-x6f26ahr 395 1 Each each DT cord-028721-x6f26ahr 395 2 lobule lobule NN cord-028721-x6f26ahr 395 3 contains contain VBZ cord-028721-x6f26ahr 395 4 two two CD cord-028721-x6f26ahr 395 5 to to TO cord-028721-x6f26ahr 395 6 four four CD cord-028721-x6f26ahr 395 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 395 8 tubules tubule NNS cord-028721-x6f26ahr 395 9 and and CC cord-028721-x6f26ahr 395 10 numerous numerous JJ cord-028721-x6f26ahr 395 11 Leydig Leydig NNP cord-028721-x6f26ahr 395 12 cells cell NNS cord-028721-x6f26ahr 395 13 . . . cord-028721-x6f26ahr 396 1 121 121 CD cord-028721-x6f26ahr 396 2 Adult adult NN cord-028721-x6f26ahr 396 3 seminiferous seminiferous JJ cord-028721-x6f26ahr 396 4 tubules tubule NNS cord-028721-x6f26ahr 396 5 are be VBP cord-028721-x6f26ahr 396 6 180 180 CD cord-028721-x6f26ahr 396 7 - - SYM cord-028721-x6f26ahr 396 8 200 200 CD cord-028721-x6f26ahr 396 9 µm µm NN cord-028721-x6f26ahr 396 10 in in IN cord-028721-x6f26ahr 396 11 diameter diameter NN cord-028721-x6f26ahr 396 12 and and CC cord-028721-x6f26ahr 396 13 30 30 CD cord-028721-x6f26ahr 396 14 - - SYM cord-028721-x6f26ahr 396 15 80 80 CD cord-028721-x6f26ahr 396 16 cm cm NNS cord-028721-x6f26ahr 396 17 long long RB cord-028721-x6f26ahr 396 18 . . . cord-028721-x6f26ahr 397 1 The the DT cord-028721-x6f26ahr 397 2 total total JJ cord-028721-x6f26ahr 397 3 combined combined JJ cord-028721-x6f26ahr 397 4 length length NN cord-028721-x6f26ahr 397 5 of of IN cord-028721-x6f26ahr 397 6 the the DT cord-028721-x6f26ahr 397 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 397 8 tubules tubule NNS cord-028721-x6f26ahr 397 9 is be VBZ cord-028721-x6f26ahr 397 10 about about RB cord-028721-x6f26ahr 397 11 540 540 CD cord-028721-x6f26ahr 397 12 m m NN cord-028721-x6f26ahr 397 13 ( ( -LRB- cord-028721-x6f26ahr 397 14 range range NN cord-028721-x6f26ahr 397 15 , , , cord-028721-x6f26ahr 397 16 299 299 CD cord-028721-x6f26ahr 397 17 - - SYM cord-028721-x6f26ahr 397 18 981 981 CD cord-028721-x6f26ahr 397 19 m m CD cord-028721-x6f26ahr 397 20 ) ) -RRB- cord-028721-x6f26ahr 397 21 . . . cord-028721-x6f26ahr 398 1 122 122 CD cord-028721-x6f26ahr 399 1 They -PRON- PRP cord-028721-x6f26ahr 399 2 are be VBP cord-028721-x6f26ahr 399 3 highly highly RB cord-028721-x6f26ahr 399 4 convoluted convoluted JJ cord-028721-x6f26ahr 399 5 and and CC cord-028721-x6f26ahr 399 6 tightly tightly RB cord-028721-x6f26ahr 399 7 packed pack VBN cord-028721-x6f26ahr 399 8 within within IN cord-028721-x6f26ahr 399 9 the the DT cord-028721-x6f26ahr 399 10 lobules lobule NNS cord-028721-x6f26ahr 399 11 . . . cord-028721-x6f26ahr 400 1 The the DT cord-028721-x6f26ahr 400 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 400 3 tubules tubule NNS cord-028721-x6f26ahr 400 4 comprise comprise VBP cord-028721-x6f26ahr 400 5 about about RB cord-028721-x6f26ahr 400 6 80 80 CD cord-028721-x6f26ahr 400 7 % % NN cord-028721-x6f26ahr 400 8 of of IN cord-028721-x6f26ahr 400 9 testicular testicular JJ cord-028721-x6f26ahr 400 10 volume volume NN cord-028721-x6f26ahr 400 11 . . . cord-028721-x6f26ahr 401 1 The the DT cord-028721-x6f26ahr 401 2 tubular tubular JJ cord-028721-x6f26ahr 401 3 lining lining NN cord-028721-x6f26ahr 401 4 of of IN cord-028721-x6f26ahr 401 5 germ germ NN cord-028721-x6f26ahr 401 6 cells cell NNS cord-028721-x6f26ahr 401 7 and and CC cord-028721-x6f26ahr 401 8 Sertoli sertoli JJ cord-028721-x6f26ahr 401 9 cells cell NNS cord-028721-x6f26ahr 401 10 is be VBZ cord-028721-x6f26ahr 401 11 surrounded surround VBN cord-028721-x6f26ahr 401 12 by by IN cord-028721-x6f26ahr 401 13 a a DT cord-028721-x6f26ahr 401 14 lamina lamina JJ cord-028721-x6f26ahr 401 15 propria propria FW cord-028721-x6f26ahr 401 16 ( ( -LRB- cord-028721-x6f26ahr 401 17 tunica tunica NNP cord-028721-x6f26ahr 401 18 propria propria NNP cord-028721-x6f26ahr 401 19 ) ) -RRB- cord-028721-x6f26ahr 401 20 ( ( -LRB- cord-028721-x6f26ahr 401 21 Fig Fig NNP cord-028721-x6f26ahr 401 22 . . . cord-028721-x6f26ahr 401 23 _SP cord-028721-x6f26ahr 402 1 12 12 CD cord-028721-x6f26ahr 402 2 - - SYM cord-028721-x6f26ahr 402 3 18 18 CD cord-028721-x6f26ahr 402 4 ) ) -RRB- cord-028721-x6f26ahr 402 5 . . . cord-028721-x6f26ahr 403 1 Sertoli sertoli JJ cord-028721-x6f26ahr 403 2 cells cell NNS cord-028721-x6f26ahr 403 3 are be VBP cord-028721-x6f26ahr 403 4 columnar columnar JJ cord-028721-x6f26ahr 403 5 cells cell NNS cord-028721-x6f26ahr 403 6 that that WDT cord-028721-x6f26ahr 403 7 extend extend VBP cord-028721-x6f26ahr 403 8 from from IN cord-028721-x6f26ahr 403 9 the the DT cord-028721-x6f26ahr 403 10 basal basal NN cord-028721-x6f26ahr 403 11 lamina lamina NN cord-028721-x6f26ahr 403 12 to to IN cord-028721-x6f26ahr 403 13 the the DT cord-028721-x6f26ahr 403 14 tubular tubular JJ cord-028721-x6f26ahr 403 15 lumen lumen NN cord-028721-x6f26ahr 403 16 , , , cord-028721-x6f26ahr 403 17 with with IN cord-028721-x6f26ahr 403 18 10 10 CD cord-028721-x6f26ahr 403 19 - - SYM cord-028721-x6f26ahr 403 20 12 12 CD cord-028721-x6f26ahr 403 21 cells cell NNS cord-028721-x6f26ahr 403 22 per per IN cord-028721-x6f26ahr 403 23 crosssectioned crosssectioned JJ cord-028721-x6f26ahr 403 24 tubule tubule NN cord-028721-x6f26ahr 403 25 . . . cord-028721-x6f26ahr 404 1 They -PRON- PRP cord-028721-x6f26ahr 404 2 are be VBP cord-028721-x6f26ahr 404 3 easily easily RB cord-028721-x6f26ahr 404 4 identifi identifi VBN cord-028721-x6f26ahr 404 5 ed ed NN cord-028721-x6f26ahr 404 6 by by IN cord-028721-x6f26ahr 404 7 their -PRON- PRP$ cord-028721-x6f26ahr 404 8 nuclear nuclear JJ cord-028721-x6f26ahr 404 9 characteristics characteristic NNS cord-028721-x6f26ahr 404 10 . . . cord-028721-x6f26ahr 405 1 The the DT cord-028721-x6f26ahr 405 2 nucleus nucleus NN cord-028721-x6f26ahr 405 3 is be VBZ cord-028721-x6f26ahr 405 4 located locate VBN cord-028721-x6f26ahr 405 5 near near IN cord-028721-x6f26ahr 405 6 the the DT cord-028721-x6f26ahr 405 7 basal basal NN cord-028721-x6f26ahr 405 8 lamina lamina NN cord-028721-x6f26ahr 405 9 and and CC cord-028721-x6f26ahr 405 10 has have VBZ cord-028721-x6f26ahr 405 11 a a DT cord-028721-x6f26ahr 405 12 triangular triangular JJ cord-028721-x6f26ahr 405 13 shape shape NN cord-028721-x6f26ahr 405 14 with with IN cord-028721-x6f26ahr 405 15 indented indented JJ cord-028721-x6f26ahr 405 16 outline outline NN cord-028721-x6f26ahr 405 17 , , , cord-028721-x6f26ahr 405 18 pale pale JJ cord-028721-x6f26ahr 405 19 chromatin chromatin NN cord-028721-x6f26ahr 405 20 , , , cord-028721-x6f26ahr 405 21 and and CC cord-028721-x6f26ahr 405 22 a a DT cord-028721-x6f26ahr 405 23 large large JJ cord-028721-x6f26ahr 405 24 central central JJ cord-028721-x6f26ahr 405 25 nucleolus nucleolus NN cord-028721-x6f26ahr 405 26 ( ( -LRB- cord-028721-x6f26ahr 405 27 Fig Fig NNP cord-028721-x6f26ahr 405 28 . . . cord-028721-x6f26ahr 405 29 12 12 CD cord-028721-x6f26ahr 405 30 - - SYM cord-028721-x6f26ahr 405 31 19 19 CD cord-028721-x6f26ahr 405 32 ) ) -RRB- cord-028721-x6f26ahr 405 33 . . . cord-028721-x6f26ahr 406 1 Charcot Charcot NNP cord-028721-x6f26ahr 406 2 - - HYPH cord-028721-x6f26ahr 406 3 Böttcher Böttcher NNP cord-028721-x6f26ahr 406 4 's 's POS cord-028721-x6f26ahr 406 5 crystals crystal NNS cord-028721-x6f26ahr 406 6 and and CC cord-028721-x6f26ahr 406 7 lipid lipid NN cord-028721-x6f26ahr 406 8 droplets droplet NNS cord-028721-x6f26ahr 406 9 often often RB cord-028721-x6f26ahr 406 10 are be VBP cord-028721-x6f26ahr 406 11 visible visible JJ cord-028721-x6f26ahr 406 12 in in IN cord-028721-x6f26ahr 406 13 the the DT cord-028721-x6f26ahr 406 14 cytoplasm cytoplasm NN cord-028721-x6f26ahr 406 15 . . . cord-028721-x6f26ahr 407 1 [ [ -LRB- cord-028721-x6f26ahr 407 2 123 123 CD cord-028721-x6f26ahr 407 3 ] ] -RRB- cord-028721-x6f26ahr 407 4 [ [ -LRB- cord-028721-x6f26ahr 407 5 124 124 CD cord-028721-x6f26ahr 407 6 ] ] -RRB- cord-028721-x6f26ahr 408 1 [ [ -LRB- cord-028721-x6f26ahr 408 2 125 125 CD cord-028721-x6f26ahr 408 3 ] ] -RRB- cord-028721-x6f26ahr 408 4 [ [ -LRB- cord-028721-x6f26ahr 408 5 126 126 CD cord-028721-x6f26ahr 408 6 ] ] -RRB- cord-028721-x6f26ahr 409 1 Ultrastructurally Ultrastructurally NNP cord-028721-x6f26ahr 409 2 , , , cord-028721-x6f26ahr 409 3 Sertoli Sertoli NNP cord-028721-x6f26ahr 409 4 cells cell NNS cord-028721-x6f26ahr 409 5 have have VBP cord-028721-x6f26ahr 409 6 characteristic characteristic JJ cord-028721-x6f26ahr 409 7 nucleoli nucleoli NN cord-028721-x6f26ahr 409 8 , , , cord-028721-x6f26ahr 409 9 plasma plasma NN cord-028721-x6f26ahr 409 10 membranes membrane NNS cord-028721-x6f26ahr 409 11 , , , cord-028721-x6f26ahr 409 12 and and CC cord-028721-x6f26ahr 409 13 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 409 14 components component NNS cord-028721-x6f26ahr 409 15 . . . cord-028721-x6f26ahr 410 1 The the DT cord-028721-x6f26ahr 410 2 nucleolus nucleolus NN cord-028721-x6f26ahr 410 3 has have VBZ cord-028721-x6f26ahr 410 4 a a DT cord-028721-x6f26ahr 410 5 tripartite tripartite JJ cord-028721-x6f26ahr 410 6 structure structure NN cord-028721-x6f26ahr 410 7 with with IN cord-028721-x6f26ahr 410 8 a a DT cord-028721-x6f26ahr 410 9 round round JJ cord-028721-x6f26ahr 410 10 fi fi NNP cord-028721-x6f26ahr 410 11 brillar brillar NNP cord-028721-x6f26ahr 410 12 center center NNP cord-028721-x6f26ahr 410 13 , , , cord-028721-x6f26ahr 410 14 a a DT cord-028721-x6f26ahr 410 15 compact compact JJ cord-028721-x6f26ahr 410 16 granular granular JJ cord-028721-x6f26ahr 410 17 portion portion NN cord-028721-x6f26ahr 410 18 , , , cord-028721-x6f26ahr 410 19 and and CC cord-028721-x6f26ahr 410 20 a a DT cord-028721-x6f26ahr 410 21 three three CD cord-028721-x6f26ahr 410 22 - - HYPH cord-028721-x6f26ahr 410 23 dimensional dimensional JJ cord-028721-x6f26ahr 410 24 net net NN cord-028721-x6f26ahr 410 25 composed compose VBN cord-028721-x6f26ahr 410 26 of of IN cord-028721-x6f26ahr 410 27 intermingled intermingle VBN cord-028721-x6f26ahr 410 28 fi fi NN cord-028721-x6f26ahr 410 29 brillar brillar NN cord-028721-x6f26ahr 410 30 and and CC cord-028721-x6f26ahr 410 31 granular granular JJ cord-028721-x6f26ahr 410 32 portions portion NNS cord-028721-x6f26ahr 410 33 . . . cord-028721-x6f26ahr 411 1 [ [ -LRB- cord-028721-x6f26ahr 411 2 127 127 CD cord-028721-x6f26ahr 411 3 ] ] -RRB- cord-028721-x6f26ahr 411 4 [ [ -LRB- cord-028721-x6f26ahr 411 5 128 128 CD cord-028721-x6f26ahr 411 6 ] ] -RRB- cord-028721-x6f26ahr 412 1 [ [ -LRB- cord-028721-x6f26ahr 412 2 129 129 CD cord-028721-x6f26ahr 412 3 ] ] -RRB- cord-028721-x6f26ahr 413 1 The the DT cord-028721-x6f26ahr 413 2 plasma plasma NN cord-028721-x6f26ahr 413 3 membrane membrane NN cord-028721-x6f26ahr 413 4 has have VBZ cord-028721-x6f26ahr 413 5 two two CD cord-028721-x6f26ahr 413 6 types type NNS cord-028721-x6f26ahr 413 7 of of IN cord-028721-x6f26ahr 413 8 intercellular intercellular JJ cord-028721-x6f26ahr 413 9 junction junction NN cord-028721-x6f26ahr 413 10 which which WDT cord-028721-x6f26ahr 413 11 develop develop VBP cord-028721-x6f26ahr 413 12 at at IN cord-028721-x6f26ahr 413 13 puberty puberty NN cord-028721-x6f26ahr 413 14 : : : cord-028721-x6f26ahr 413 15 junctions junction NNS cord-028721-x6f26ahr 413 16 between between IN cord-028721-x6f26ahr 413 17 adjacent adjacent JJ cord-028721-x6f26ahr 413 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 413 19 cells cell NNS cord-028721-x6f26ahr 413 20 , , , cord-028721-x6f26ahr 413 21 and and CC cord-028721-x6f26ahr 413 22 junctions junction NNS cord-028721-x6f26ahr 413 23 between between IN cord-028721-x6f26ahr 413 24 Sertoli Sertoli NNP cord-028721-x6f26ahr 413 25 cells cell NNS cord-028721-x6f26ahr 413 26 and and CC cord-028721-x6f26ahr 413 27 germ germ NN cord-028721-x6f26ahr 413 28 cells cell NNS cord-028721-x6f26ahr 413 29 . . . cord-028721-x6f26ahr 414 1 130 130 CD cord-028721-x6f26ahr 415 1 The the DT cord-028721-x6f26ahr 415 2 inter inter JJ cord-028721-x6f26ahr 415 3 - - JJ cord-028721-x6f26ahr 415 4 Sertoli sertoli JJ cord-028721-x6f26ahr 415 5 cell cell NN cord-028721-x6f26ahr 415 6 junctions junction NNS cord-028721-x6f26ahr 415 7 are be VBP cord-028721-x6f26ahr 415 8 tightjunction tightjunction NN cord-028721-x6f26ahr 415 9 complexes complex NNS cord-028721-x6f26ahr 415 10 . . . cord-028721-x6f26ahr 416 1 The the DT cord-028721-x6f26ahr 416 2 adjacent adjacent JJ cord-028721-x6f26ahr 416 3 cytoplasm cytoplasm NN cord-028721-x6f26ahr 416 4 has have VBZ cord-028721-x6f26ahr 416 5 numerous numerous JJ cord-028721-x6f26ahr 416 6 actin actin NN cord-028721-x6f26ahr 416 7 fi fi NN cord-028721-x6f26ahr 416 8 laments lament NNS cord-028721-x6f26ahr 416 9 and and CC cord-028721-x6f26ahr 416 10 parallel parallel RB cord-028721-x6f26ahr 416 11 - - HYPH cord-028721-x6f26ahr 416 12 arranged arrange VBN cord-028721-x6f26ahr 416 13 smooth smooth JJ cord-028721-x6f26ahr 416 14 endoplasmic endoplasmic NN cord-028721-x6f26ahr 416 15 reticula reticula NN cord-028721-x6f26ahr 416 16 cisternae cisternae NNP cord-028721-x6f26ahr 416 17 . . . cord-028721-x6f26ahr 417 1 In in IN cord-028721-x6f26ahr 417 2 adjacent adjacent JJ cord-028721-x6f26ahr 417 3 plasma plasma NN cord-028721-x6f26ahr 417 4 membranes membrane NNS cord-028721-x6f26ahr 417 5 there there EX cord-028721-x6f26ahr 417 6 are be VBP cord-028721-x6f26ahr 417 7 adhesion adhesion NN cord-028721-x6f26ahr 417 8 molecules molecule NNS cord-028721-x6f26ahr 417 9 , , , cord-028721-x6f26ahr 417 10 including include VBG cord-028721-x6f26ahr 417 11 connexin-43 connexin-43 NN cord-028721-x6f26ahr 417 12 . . . cord-028721-x6f26ahr 418 1 Between between IN cord-028721-x6f26ahr 418 2 the the DT cord-028721-x6f26ahr 418 3 plasma plasma NN cord-028721-x6f26ahr 418 4 membrane membrane NN cord-028721-x6f26ahr 418 5 and and CC cord-028721-x6f26ahr 418 6 the the DT cord-028721-x6f26ahr 418 7 adjacent adjacent JJ cord-028721-x6f26ahr 418 8 endoplasmic endoplasmic NN cord-028721-x6f26ahr 418 9 reticulum reticulum NN cord-028721-x6f26ahr 418 10 cisterna cisterna NNP cord-028721-x6f26ahr 418 11 there there EX cord-028721-x6f26ahr 418 12 are be VBP cord-028721-x6f26ahr 418 13 many many JJ cord-028721-x6f26ahr 418 14 molecules molecule NNS cord-028721-x6f26ahr 418 15 , , , cord-028721-x6f26ahr 418 16 including include VBG cord-028721-x6f26ahr 418 17 those those DT cord-028721-x6f26ahr 418 18 required require VBN cord-028721-x6f26ahr 418 19 for for IN cord-028721-x6f26ahr 418 20 actin actin NN cord-028721-x6f26ahr 418 21 fi fi NNP cord-028721-x6f26ahr 418 22 lament lament NNP cord-028721-x6f26ahr 418 23 anchorage anchorage NNP cord-028721-x6f26ahr 418 24 , , , cord-028721-x6f26ahr 418 25 vinculin vinculin NNP cord-028721-x6f26ahr 418 26 , , , cord-028721-x6f26ahr 418 27 zonula zonula NNP cord-028721-x6f26ahr 418 28 occludens-1 occludens-1 NNP cord-028721-x6f26ahr 418 29 , , , cord-028721-x6f26ahr 418 30 plakoglobin plakoglobin NNP cord-028721-x6f26ahr 418 31 , , , cord-028721-x6f26ahr 418 32 and and CC cord-028721-x6f26ahr 418 33 radixin radixin NNP cord-028721-x6f26ahr 418 34 . . . cord-028721-x6f26ahr 419 1 The the DT cord-028721-x6f26ahr 419 2 inter inter JJ cord-028721-x6f26ahr 419 3 - - JJ cord-028721-x6f26ahr 419 4 Sertoli sertoli JJ cord-028721-x6f26ahr 419 5 cell cell NN cord-028721-x6f26ahr 419 6 junctions junction NNS cord-028721-x6f26ahr 419 7 are be VBP cord-028721-x6f26ahr 419 8 the the DT cord-028721-x6f26ahr 419 9 morphologic morphologic JJ cord-028721-x6f26ahr 419 10 basis basis NN cord-028721-x6f26ahr 419 11 for for IN cord-028721-x6f26ahr 419 12 the the DT cord-028721-x6f26ahr 419 13 blood blood NN cord-028721-x6f26ahr 419 14 - - HYPH cord-028721-x6f26ahr 419 15 testis testis NN cord-028721-x6f26ahr 419 16 barrier barrier NN cord-028721-x6f26ahr 419 17 and and CC cord-028721-x6f26ahr 419 18 divide divide VB cord-028721-x6f26ahr 419 19 the the DT cord-028721-x6f26ahr 419 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 419 21 epithelium epithelium NN cord-028721-x6f26ahr 419 22 into into IN cord-028721-x6f26ahr 419 23 two two CD cord-028721-x6f26ahr 419 24 compartments compartment NNS cord-028721-x6f26ahr 419 25 : : : cord-028721-x6f26ahr 419 26 the the DT cord-028721-x6f26ahr 419 27 basal basal NNP cord-028721-x6f26ahr 419 28 compartment compartment NNP cord-028721-x6f26ahr 419 29 ( ( -LRB- cord-028721-x6f26ahr 419 30 which which WDT cord-028721-x6f26ahr 419 31 contains contain VBZ cord-028721-x6f26ahr 419 32 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 419 33 and and CC cord-028721-x6f26ahr 419 34 newly newly RB cord-028721-x6f26ahr 419 35 formed form VBN cord-028721-x6f26ahr 419 36 primary primary JJ cord-028721-x6f26ahr 419 37 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 419 38 ) ) -RRB- cord-028721-x6f26ahr 419 39 and and CC cord-028721-x6f26ahr 419 40 the the DT cord-028721-x6f26ahr 419 41 adluminal adluminal NNP cord-028721-x6f26ahr 419 42 compartment compartment NNP cord-028721-x6f26ahr 419 43 ( ( -LRB- cord-028721-x6f26ahr 419 44 which which WDT cord-028721-x6f26ahr 419 45 contains contain VBZ cord-028721-x6f26ahr 419 46 meiotic meiotic JJ cord-028721-x6f26ahr 419 47 primary primary JJ cord-028721-x6f26ahr 419 48 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 419 49 , , , cord-028721-x6f26ahr 419 50 secondary secondary JJ cord-028721-x6f26ahr 419 51 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 419 52 and and CC cord-028721-x6f26ahr 419 53 spermatids spermatids NNP cord-028721-x6f26ahr 419 54 ) ) -RRB- cord-028721-x6f26ahr 419 55 . . . cord-028721-x6f26ahr 420 1 These these DT cord-028721-x6f26ahr 420 2 junctions junction NNS cord-028721-x6f26ahr 420 3 permit permit VBP cord-028721-x6f26ahr 420 4 each each DT cord-028721-x6f26ahr 420 5 compartment compartment NN cord-028721-x6f26ahr 420 6 to to TO cord-028721-x6f26ahr 420 7 have have VB cord-028721-x6f26ahr 420 8 its -PRON- PRP$ cord-028721-x6f26ahr 420 9 own own JJ cord-028721-x6f26ahr 420 10 microenvironment microenvironment NN cord-028721-x6f26ahr 420 11 for for IN cord-028721-x6f26ahr 420 12 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 420 13 development development NN cord-028721-x6f26ahr 420 14 . . . cord-028721-x6f26ahr 421 1 [ [ -LRB- cord-028721-x6f26ahr 421 2 131 131 CD cord-028721-x6f26ahr 421 3 ] ] -RRB- cord-028721-x6f26ahr 421 4 [ [ -LRB- cord-028721-x6f26ahr 421 5 132 132 CD cord-028721-x6f26ahr 421 6 ] ] -RRB- cord-028721-x6f26ahr 422 1 [ [ -LRB- cord-028721-x6f26ahr 422 2 133 133 CD cord-028721-x6f26ahr 422 3 ] ] -RRB- cord-028721-x6f26ahr 423 1 The the DT cord-028721-x6f26ahr 423 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 423 3 cell cell NN cord-028721-x6f26ahr 423 4 - - HYPH cord-028721-x6f26ahr 423 5 germ germ NN cord-028721-x6f26ahr 423 6 cell cell NN cord-028721-x6f26ahr 423 7 junctions junction NNS cord-028721-x6f26ahr 423 8 persist persist VBP cord-028721-x6f26ahr 423 9 from from IN cord-028721-x6f26ahr 423 10 the the DT cord-028721-x6f26ahr 423 11 primary primary JJ cord-028721-x6f26ahr 423 12 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 423 13 stage stage NN cord-028721-x6f26ahr 423 14 through through IN cord-028721-x6f26ahr 423 15 spermatozoon spermatozoon NN cord-028721-x6f26ahr 423 16 release release NN cord-028721-x6f26ahr 423 17 . . . cord-028721-x6f26ahr 424 1 These these DT cord-028721-x6f26ahr 424 2 junctions junction NNS cord-028721-x6f26ahr 424 3 are be VBP cord-028721-x6f26ahr 424 4 desmosomes desmosome NNS cord-028721-x6f26ahr 424 5 and and CC cord-028721-x6f26ahr 424 6 gap gap NN cord-028721-x6f26ahr 424 7 - - HYPH cord-028721-x6f26ahr 424 8 type type NN cord-028721-x6f26ahr 424 9 junctions junction NNS cord-028721-x6f26ahr 424 10 . . . cord-028721-x6f26ahr 425 1 The the DT cord-028721-x6f26ahr 425 2 adhesion adhesion NN cord-028721-x6f26ahr 425 3 among among IN cord-028721-x6f26ahr 425 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 425 5 cells cell NNS cord-028721-x6f26ahr 425 6 and and CC cord-028721-x6f26ahr 425 7 germ germ NN cord-028721-x6f26ahr 425 8 cells cell NNS cord-028721-x6f26ahr 425 9 is be VBZ cord-028721-x6f26ahr 425 10 mediated mediate VBN cord-028721-x6f26ahr 425 11 by by IN cord-028721-x6f26ahr 425 12 N n NN cord-028721-x6f26ahr 425 13 - - HYPH cord-028721-x6f26ahr 425 14 cadherin cadherin NN cord-028721-x6f26ahr 425 15 . . . cord-028721-x6f26ahr 426 1 These these DT cord-028721-x6f26ahr 426 2 junctions junction NNS cord-028721-x6f26ahr 426 3 have have VBP cord-028721-x6f26ahr 426 4 also also RB cord-028721-x6f26ahr 426 5 occasionally occasionally RB cord-028721-x6f26ahr 426 6 been be VBN cord-028721-x6f26ahr 426 7 observed observe VBN cord-028721-x6f26ahr 426 8 between between IN cord-028721-x6f26ahr 426 9 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 426 10 . . . cord-028721-x6f26ahr 427 1 134 134 CD cord-028721-x6f26ahr 427 2 Sertoli sertoli JJ cord-028721-x6f26ahr 427 3 cell cell NN cord-028721-x6f26ahr 427 4 cytoplasm cytoplasm NN cord-028721-x6f26ahr 427 5 contains contain VBZ cord-028721-x6f26ahr 427 6 abundant abundant JJ cord-028721-x6f26ahr 427 7 smooth smooth JJ cord-028721-x6f26ahr 427 8 endoplasmic endoplasmic NN cord-028721-x6f26ahr 427 9 reticulum reticulum NN cord-028721-x6f26ahr 427 10 , , , cord-028721-x6f26ahr 427 11 elongated elongated JJ cord-028721-x6f26ahr 427 12 mitochondria mitochondrion NNS cord-028721-x6f26ahr 427 13 , , , cord-028721-x6f26ahr 427 14 annulate annulate NN cord-028721-x6f26ahr 427 15 lamellae lamella NNS cord-028721-x6f26ahr 427 16 , , , cord-028721-x6f26ahr 427 17 lysosomes lysosome NNS cord-028721-x6f26ahr 427 18 , , , cord-028721-x6f26ahr 427 19 residual residual JJ cord-028721-x6f26ahr 427 20 bodies body NNS cord-028721-x6f26ahr 427 21 , , , cord-028721-x6f26ahr 427 22 glycogen glycogen NN cord-028721-x6f26ahr 427 23 granules granule NNS cord-028721-x6f26ahr 427 24 , , , cord-028721-x6f26ahr 427 25 microtubules microtubule NNS cord-028721-x6f26ahr 427 26 , , , cord-028721-x6f26ahr 427 27 vimentin vimentin NN cord-028721-x6f26ahr 427 28 fi fi NN cord-028721-x6f26ahr 427 29 laments lament NNS cord-028721-x6f26ahr 427 30 around around IN cord-028721-x6f26ahr 427 31 the the DT cord-028721-x6f26ahr 427 32 nucleus nucleus NN cord-028721-x6f26ahr 427 33 , , , cord-028721-x6f26ahr 427 34 135 135 CD cord-028721-x6f26ahr 427 35 actin actin NN cord-028721-x6f26ahr 427 36 fi fi NN cord-028721-x6f26ahr 427 37 laments lament NNS cord-028721-x6f26ahr 427 38 in in IN cord-028721-x6f26ahr 427 39 both both DT cord-028721-x6f26ahr 427 40 inter inter JJ cord-028721-x6f26ahr 427 41 - - JJ cord-028721-x6f26ahr 427 42 Sertoli sertoli JJ cord-028721-x6f26ahr 427 43 cell cell NN cord-028721-x6f26ahr 427 44 junctions junction NNS cord-028721-x6f26ahr 427 45 and and CC cord-028721-x6f26ahr 427 46 ectoplasmic ectoplasmic JJ cord-028721-x6f26ahr 427 47 specializations specialization NNS cord-028721-x6f26ahr 427 48 that that WDT cord-028721-x6f26ahr 427 49 surround surround VBP cord-028721-x6f26ahr 427 50 germ germ NN cord-028721-x6f26ahr 427 51 cells cell NNS cord-028721-x6f26ahr 427 52 , , , cord-028721-x6f26ahr 427 53 136 136 CD cord-028721-x6f26ahr 427 54 lipid lipid NN cord-028721-x6f26ahr 427 55 droplets droplet NNS cord-028721-x6f26ahr 427 56 in in IN cord-028721-x6f26ahr 427 57 amounts amount NNS cord-028721-x6f26ahr 427 58 that that WDT cord-028721-x6f26ahr 427 59 vary vary VBP cord-028721-x6f26ahr 427 60 with with IN cord-028721-x6f26ahr 427 61 the the DT cord-028721-x6f26ahr 427 62 seminiferous seminiferous JJ cord-028721-x6f26ahr 427 63 tubular tubular JJ cord-028721-x6f26ahr 427 64 cycle cycle NN cord-028721-x6f26ahr 427 65 , , , cord-028721-x6f26ahr 427 66 137 137 CD cord-028721-x6f26ahr 427 67 Charcot Charcot NNP cord-028721-x6f26ahr 427 68 - - HYPH cord-028721-x6f26ahr 427 69 Böttcher Böttcher NNP cord-028721-x6f26ahr 427 70 crystals crystal NNS cord-028721-x6f26ahr 427 71 ( ( -LRB- cord-028721-x6f26ahr 428 1 structures structure NNS cord-028721-x6f26ahr 428 2 several several JJ cord-028721-x6f26ahr 428 3 micrometers micrometer NNS cord-028721-x6f26ahr 428 4 long long RB cord-028721-x6f26ahr 428 5 , , , cord-028721-x6f26ahr 428 6 formed form VBN cord-028721-x6f26ahr 428 7 of of IN cord-028721-x6f26ahr 428 8 multiple multiple JJ cord-028721-x6f26ahr 428 9 parallel parallel JJ cord-028721-x6f26ahr 428 10 laminae laminae NN cord-028721-x6f26ahr 428 11 of of IN cord-028721-x6f26ahr 428 12 protein protein NN cord-028721-x6f26ahr 428 13 ) ) -RRB- cord-028721-x6f26ahr 428 14 , , , cord-028721-x6f26ahr 428 15 and and CC cord-028721-x6f26ahr 428 16 scant scant JJ cord-028721-x6f26ahr 428 17 rough rough JJ cord-028721-x6f26ahr 428 18 endoplasmic endoplasmic NN cord-028721-x6f26ahr 428 19 reticulum reticulum NN cord-028721-x6f26ahr 428 20 and and CC cord-028721-x6f26ahr 428 21 ribosomes ribosome NNS cord-028721-x6f26ahr 428 22 . . . cord-028721-x6f26ahr 429 1 138 138 CD cord-028721-x6f26ahr 430 1 The the DT cord-028721-x6f26ahr 430 2 number number NN cord-028721-x6f26ahr 430 3 of of IN cord-028721-x6f26ahr 430 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 430 5 cells cell NNS cord-028721-x6f26ahr 430 6 decreases decrease VBZ cord-028721-x6f26ahr 430 7 with with IN cord-028721-x6f26ahr 430 8 age age NN cord-028721-x6f26ahr 430 9 , , , cord-028721-x6f26ahr 430 10 from from IN cord-028721-x6f26ahr 430 11 about about IN cord-028721-x6f26ahr 430 12 250 250 CD cord-028721-x6f26ahr 430 13 million million CD cord-028721-x6f26ahr 430 14 per per IN cord-028721-x6f26ahr 430 15 testis testis NN cord-028721-x6f26ahr 430 16 in in IN cord-028721-x6f26ahr 430 17 young young JJ cord-028721-x6f26ahr 430 18 men man NNS cord-028721-x6f26ahr 430 19 to to IN cord-028721-x6f26ahr 430 20 125 125 CD cord-028721-x6f26ahr 430 21 million million CD cord-028721-x6f26ahr 430 22 in in IN cord-028721-x6f26ahr 430 23 men man NNS cord-028721-x6f26ahr 430 24 over over IN cord-028721-x6f26ahr 430 25 50 50 CD cord-028721-x6f26ahr 430 26 years year NNS cord-028721-x6f26ahr 430 27 . . . cord-028721-x6f26ahr 431 1 139 139 CD cord-028721-x6f26ahr 431 2 , , , cord-028721-x6f26ahr 431 3 140 140 CD cord-028721-x6f26ahr 431 4 There there EX cord-028721-x6f26ahr 431 5 is be VBZ cord-028721-x6f26ahr 431 6 a a DT cord-028721-x6f26ahr 431 7 positive positive JJ cord-028721-x6f26ahr 431 8 correlation correlation NN cord-028721-x6f26ahr 431 9 between between IN cord-028721-x6f26ahr 431 10 the the DT cord-028721-x6f26ahr 431 11 number number NN cord-028721-x6f26ahr 431 12 of of IN cord-028721-x6f26ahr 431 13 Sertoli sertoli JJ cord-028721-x6f26ahr 431 14 cells cell NNS cord-028721-x6f26ahr 431 15 and and CC cord-028721-x6f26ahr 431 16 daily daily JJ cord-028721-x6f26ahr 431 17 sperm sperm NN cord-028721-x6f26ahr 431 18 production production NN cord-028721-x6f26ahr 431 19 . . . cord-028721-x6f26ahr 432 1 141 141 CD cord-028721-x6f26ahr 432 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 432 3 cells cell NNS cord-028721-x6f26ahr 432 4 are be VBP cord-028721-x6f26ahr 432 5 the the DT cord-028721-x6f26ahr 432 6 target target NN cord-028721-x6f26ahr 432 7 of of IN cord-028721-x6f26ahr 432 8 FSH FSH NNP cord-028721-x6f26ahr 432 9 142 142 CD cord-028721-x6f26ahr 432 10 , , , cord-028721-x6f26ahr 432 11 143 143 CD cord-028721-x6f26ahr 432 12 and and CC cord-028721-x6f26ahr 432 13 androgen androgen NN cord-028721-x6f26ahr 432 14 action action NN cord-028721-x6f26ahr 433 1 ( ( -LRB- cord-028721-x6f26ahr 433 2 Fig Fig NNP cord-028721-x6f26ahr 433 3 . . . cord-028721-x6f26ahr 433 4 12 12 CD cord-028721-x6f26ahr 433 5 -21 -21 NN cord-028721-x6f26ahr 433 6 ) ) -RRB- cord-028721-x6f26ahr 433 7 . . . cord-028721-x6f26ahr 434 1 144 144 CD cord-028721-x6f26ahr 435 1 In in IN cord-028721-x6f26ahr 435 2 adulthood adulthood NN cord-028721-x6f26ahr 435 3 , , , cord-028721-x6f26ahr 435 4 they -PRON- PRP cord-028721-x6f26ahr 435 5 produce produce VBP cord-028721-x6f26ahr 435 6 testicular testicular JJ cord-028721-x6f26ahr 435 7 fl fl NNP cord-028721-x6f26ahr 435 8 uid uid NN cord-028721-x6f26ahr 435 9 through through IN cord-028721-x6f26ahr 435 10 an an DT cord-028721-x6f26ahr 435 11 active active JJ cord-028721-x6f26ahr 435 12 transport transport NN cord-028721-x6f26ahr 435 13 mechanism mechanism NN cord-028721-x6f26ahr 435 14 , , , cord-028721-x6f26ahr 435 15 and and CC cord-028721-x6f26ahr 435 16 synthesize synthesize VB cord-028721-x6f26ahr 435 17 multiple multiple JJ cord-028721-x6f26ahr 435 18 products product NNS cord-028721-x6f26ahr 435 19 to to TO cord-028721-x6f26ahr 435 20 ensure ensure VB cord-028721-x6f26ahr 435 21 the the DT cord-028721-x6f26ahr 435 22 nutrition nutrition NN cord-028721-x6f26ahr 435 23 , , , cord-028721-x6f26ahr 435 24 proliferation proliferation NN cord-028721-x6f26ahr 435 25 and and CC cord-028721-x6f26ahr 435 26 maturation maturation NN cord-028721-x6f26ahr 435 27 of of IN cord-028721-x6f26ahr 435 28 germ germ NN cord-028721-x6f26ahr 435 29 cells cell NNS cord-028721-x6f26ahr 435 30 , , , cord-028721-x6f26ahr 435 31 to to TO cord-028721-x6f26ahr 435 32 stimulate stimulate VB cord-028721-x6f26ahr 435 33 other other JJ cord-028721-x6f26ahr 435 34 cells cell NNS cord-028721-x6f26ahr 435 35 such such JJ cord-028721-x6f26ahr 435 36 as as IN cord-028721-x6f26ahr 435 37 Leydig Leydig NNP cord-028721-x6f26ahr 435 38 cells cell NNS cord-028721-x6f26ahr 435 39 and and CC cord-028721-x6f26ahr 435 40 peritubular peritubular JJ cord-028721-x6f26ahr 435 41 cells cell NNS cord-028721-x6f26ahr 435 42 , , , cord-028721-x6f26ahr 435 43 145 145 CD cord-028721-x6f26ahr 435 44 and and CC cord-028721-x6f26ahr 435 45 to to TO cord-028721-x6f26ahr 435 46 contribute contribute VB cord-028721-x6f26ahr 435 47 to to IN cord-028721-x6f26ahr 435 48 hormonal hormonal JJ cord-028721-x6f26ahr 435 49 regulation regulation NN cord-028721-x6f26ahr 435 50 ( ( -LRB- cord-028721-x6f26ahr 435 51 inhibin inhibin NNP cord-028721-x6f26ahr 435 52 secretion secretion NN cord-028721-x6f26ahr 435 53 ) ) -RRB- cord-028721-x6f26ahr 436 1 ( ( -LRB- cord-028721-x6f26ahr 436 2 Table table NN cord-028721-x6f26ahr 436 3 12 12 CD cord-028721-x6f26ahr 436 4 -1 -1 CD cord-028721-x6f26ahr 436 5 ) ) -RRB- cord-028721-x6f26ahr 436 6 . . . cord-028721-x6f26ahr 437 1 The the DT cord-028721-x6f26ahr 437 2 transport transport NN cord-028721-x6f26ahr 437 3 of of IN cord-028721-x6f26ahr 437 4 small small JJ cord-028721-x6f26ahr 437 5 molecules molecule NNS cord-028721-x6f26ahr 437 6 ( ( -LRB- cord-028721-x6f26ahr 437 7 < < XX cord-028721-x6f26ahr 437 8 600 600 CD cord-028721-x6f26ahr 437 9 - - HYPH cord-028721-x6f26ahr 437 10 700 700 CD cord-028721-x6f26ahr 437 11 Da Da NNP cord-028721-x6f26ahr 437 12 ) ) -RRB- cord-028721-x6f26ahr 437 13 such such JJ cord-028721-x6f26ahr 437 14 as as IN cord-028721-x6f26ahr 437 15 pyruvate pyruvate NN cord-028721-x6f26ahr 437 16 , , , cord-028721-x6f26ahr 437 17 lactate lactate NN cord-028721-x6f26ahr 437 18 , , , cord-028721-x6f26ahr 437 19 and and CC cord-028721-x6f26ahr 437 20 probably probably RB cord-028721-x6f26ahr 437 21 choline choline NN cord-028721-x6f26ahr 437 22 from from IN cord-028721-x6f26ahr 437 23 the the DT cord-028721-x6f26ahr 437 24 Sertoli Sertoli NNP cord-028721-x6f26ahr 437 25 cell cell NN cord-028721-x6f26ahr 437 26 , , , cord-028721-x6f26ahr 437 27 to to IN cord-028721-x6f26ahr 437 28 germ germ NN cord-028721-x6f26ahr 437 29 cells cell NNS cord-028721-x6f26ahr 437 30 occurs occur VBZ cord-028721-x6f26ahr 437 31 through through IN cord-028721-x6f26ahr 437 32 gap gap NN cord-028721-x6f26ahr 437 33 junctions junction NNS cord-028721-x6f26ahr 437 34 . . . cord-028721-x6f26ahr 438 1 Large large JJ cord-028721-x6f26ahr 438 2 or or CC cord-028721-x6f26ahr 438 3 small small JJ cord-028721-x6f26ahr 438 4 soluble soluble JJ cord-028721-x6f26ahr 438 5 molecules molecule NNS cord-028721-x6f26ahr 438 6 are be VBP cord-028721-x6f26ahr 438 7 transported transport VBN cord-028721-x6f26ahr 438 8 by by IN cord-028721-x6f26ahr 438 9 proteins protein NNS cord-028721-x6f26ahr 438 10 that that WDT cord-028721-x6f26ahr 438 11 are be VBP cord-028721-x6f26ahr 438 12 synthesized synthesize VBN cord-028721-x6f26ahr 438 13 by by IN cord-028721-x6f26ahr 438 14 the the DT cord-028721-x6f26ahr 438 15 Sertoli Sertoli NNP cord-028721-x6f26ahr 438 16 cell cell NN cord-028721-x6f26ahr 438 17 , , , cord-028721-x6f26ahr 438 18 and and CC cord-028721-x6f26ahr 438 19 include include VBP cord-028721-x6f26ahr 438 20 androgen androgen NN cord-028721-x6f26ahr 438 21 - - HYPH cord-028721-x6f26ahr 438 22 binding bind VBG cord-028721-x6f26ahr 438 23 protein protein NN cord-028721-x6f26ahr 438 24 , , , cord-028721-x6f26ahr 438 25 transferrin transferrin NN cord-028721-x6f26ahr 438 26 , , , cord-028721-x6f26ahr 438 27 ceruloplas ceruloplas NN cord-028721-x6f26ahr 438 28 - - HYPH cord-028721-x6f26ahr 438 29 Embryology embryology NN cord-028721-x6f26ahr 438 30 and and CC cord-028721-x6f26ahr 438 31 anatomy anatomy NN cord-028721-x6f26ahr 438 32 of of IN cord-028721-x6f26ahr 438 33 the the DT cord-028721-x6f26ahr 438 34 testis testis NN cord-028721-x6f26ahr 438 35 min min NN cord-028721-x6f26ahr 438 36 , , , cord-028721-x6f26ahr 438 37 sulfated sulfated JJ cord-028721-x6f26ahr 438 38 glycoproteins glycoprotein NNS cord-028721-x6f26ahr 438 39 , , , cord-028721-x6f26ahr 438 40 α α NN cord-028721-x6f26ahr 438 41 2 2 CD cord-028721-x6f26ahr 438 42 -macroglobulin -macroglobulin CD cord-028721-x6f26ahr 438 43 , , , cord-028721-x6f26ahr 438 44 and and CC cord-028721-x6f26ahr 438 45 γ γ NN cord-028721-x6f26ahr 438 46 - - HYPH cord-028721-x6f26ahr 438 47 glutamyl glutamyl NNP cord-028721-x6f26ahr 438 48 transpeptidase transpeptidase NNP cord-028721-x6f26ahr 438 49 . . . cord-028721-x6f26ahr 439 1 146 146 CD cord-028721-x6f26ahr 440 1 Activin Activin NNP cord-028721-x6f26ahr 440 2 and and CC cord-028721-x6f26ahr 440 3 inhibin inhibin NNP cord-028721-x6f26ahr 440 4 are be VBP cord-028721-x6f26ahr 440 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 440 6 cell cell NN cord-028721-x6f26ahr 440 7 - - HYPH cord-028721-x6f26ahr 440 8 secreted secrete VBN cord-028721-x6f26ahr 440 9 proteins protein NNS cord-028721-x6f26ahr 440 10 that that WDT cord-028721-x6f26ahr 440 11 induce induce VBP cord-028721-x6f26ahr 440 12 the the DT cord-028721-x6f26ahr 440 13 proliferation proliferation NN cord-028721-x6f26ahr 440 14 and and CC cord-028721-x6f26ahr 440 15 differentiation differentiation NN cord-028721-x6f26ahr 440 16 of of IN cord-028721-x6f26ahr 440 17 germ germ NN cord-028721-x6f26ahr 440 18 cells cell NNS cord-028721-x6f26ahr 440 19 . . . cord-028721-x6f26ahr 441 1 Whereas whereas IN cord-028721-x6f26ahr 441 2 activin activin NNP cord-028721-x6f26ahr 441 3 stimulates stimulate VBZ cord-028721-x6f26ahr 441 4 FSH FSH NNP cord-028721-x6f26ahr 441 5 production production NN cord-028721-x6f26ahr 441 6 and and CC cord-028721-x6f26ahr 441 7 , , , cord-028721-x6f26ahr 441 8 subsequently subsequently RB cord-028721-x6f26ahr 441 9 , , , cord-028721-x6f26ahr 441 10 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 441 11 proliferation proliferation NN cord-028721-x6f26ahr 441 12 , , , cord-028721-x6f26ahr 441 13 inhibin inhibin NNP cord-028721-x6f26ahr 441 14 B B NNP cord-028721-x6f26ahr 441 15 inhibits inhibit VBZ cord-028721-x6f26ahr 441 16 FSH fsh NN cord-028721-x6f26ahr 441 17 secretion secretion NN cord-028721-x6f26ahr 441 18 , , , cord-028721-x6f26ahr 441 19 and and CC cord-028721-x6f26ahr 441 20 is be VBZ cord-028721-x6f26ahr 441 21 an an DT cord-028721-x6f26ahr 441 22 important important JJ cord-028721-x6f26ahr 441 23 marker marker NN cord-028721-x6f26ahr 441 24 of of IN cord-028721-x6f26ahr 441 25 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 441 26 . . . cord-028721-x6f26ahr 442 1 147 147 CD cord-028721-x6f26ahr 443 1 Other other JJ cord-028721-x6f26ahr 443 2 Sertoli sertoli JJ cord-028721-x6f26ahr 443 3 cell cell NN cord-028721-x6f26ahr 443 4 secretions secretion NNS cord-028721-x6f26ahr 443 5 are be VBP cord-028721-x6f26ahr 443 6 interleukins interleukin NNS cord-028721-x6f26ahr 443 7 , , , cord-028721-x6f26ahr 443 8 mainly mainly RB cord-028721-x6f26ahr 443 9 IL-1 IL-1 NNP cord-028721-x6f26ahr 443 10 , , , cord-028721-x6f26ahr 443 11 148 148 CD cord-028721-x6f26ahr 443 12 and and CC cord-028721-x6f26ahr 443 13 growth growth NN cord-028721-x6f26ahr 443 14 factors factor NNS cord-028721-x6f26ahr 443 15 such such JJ cord-028721-x6f26ahr 443 16 as as IN cord-028721-x6f26ahr 443 17 transforming transform VBG cord-028721-x6f26ahr 443 18 growth growth NN cord-028721-x6f26ahr 443 19 factor factor NN cord-028721-x6f26ahr 443 20 - - HYPH cord-028721-x6f26ahr 443 21 β β NN cord-028721-x6f26ahr 443 22 ( ( -LRB- cord-028721-x6f26ahr 443 23 TGF TGF NNP cord-028721-x6f26ahr 443 24 - - HYPH cord-028721-x6f26ahr 443 25 β β NNP cord-028721-x6f26ahr 443 26 ) ) -RRB- cord-028721-x6f26ahr 443 27 , , , cord-028721-x6f26ahr 443 28 insulin insulin NN cord-028721-x6f26ahr 443 29 growth growth NN cord-028721-x6f26ahr 443 30 factors factor NNS cord-028721-x6f26ahr 443 31 1 1 CD cord-028721-x6f26ahr 443 32 and and CC cord-028721-x6f26ahr 443 33 2 2 CD cord-028721-x6f26ahr 443 34 ( ( -LRB- cord-028721-x6f26ahr 443 35 IGF-1 IGF-1 NNP cord-028721-x6f26ahr 443 36 and and CC cord-028721-x6f26ahr 443 37 IGF-2 IGF-2 NNP cord-028721-x6f26ahr 443 38 ) ) -RRB- cord-028721-x6f26ahr 443 39 , , , cord-028721-x6f26ahr 443 40 and and CC cord-028721-x6f26ahr 443 41 seminiferous seminiferous JJ cord-028721-x6f26ahr 443 42 growth growth NN cord-028721-x6f26ahr 443 43 factor factor NN cord-028721-x6f26ahr 443 44 ( ( -LRB- cord-028721-x6f26ahr 443 45 SGF SGF NNP cord-028721-x6f26ahr 443 46 ) ) -RRB- cord-028721-x6f26ahr 443 47 or or CC cord-028721-x6f26ahr 443 48 stem stem VB cord-028721-x6f26ahr 443 49 cell cell NN cord-028721-x6f26ahr 443 50 factor factor NN cord-028721-x6f26ahr 443 51 ( ( -LRB- cord-028721-x6f26ahr 443 52 SCF SCF NNP cord-028721-x6f26ahr 443 53 ) ) -RRB- cord-028721-x6f26ahr 443 54 . . . cord-028721-x6f26ahr 444 1 Some some DT cord-028721-x6f26ahr 444 2 of of IN cord-028721-x6f26ahr 444 3 these these DT cord-028721-x6f26ahr 444 4 growth growth NN cord-028721-x6f26ahr 444 5 factors factor NNS cord-028721-x6f26ahr 444 6 , , , cord-028721-x6f26ahr 444 7 such such JJ cord-028721-x6f26ahr 444 8 as as IN cord-028721-x6f26ahr 444 9 TGF TGF NNP cord-028721-x6f26ahr 444 10 - - HYPH cord-028721-x6f26ahr 444 11 α α NNP cord-028721-x6f26ahr 444 12 , , , cord-028721-x6f26ahr 444 13 TGF TGF NNP cord-028721-x6f26ahr 444 14 - - HYPH cord-028721-x6f26ahr 444 15 β β NNP cord-028721-x6f26ahr 444 16 , , , cord-028721-x6f26ahr 444 17 and and CC cord-028721-x6f26ahr 444 18 IGF-1 IGF-1 NNP cord-028721-x6f26ahr 444 19 , , , cord-028721-x6f26ahr 444 20 are be VBP cord-028721-x6f26ahr 444 21 involved involve VBN cord-028721-x6f26ahr 444 22 in in IN cord-028721-x6f26ahr 444 23 the the DT cord-028721-x6f26ahr 444 24 regulation regulation NN cord-028721-x6f26ahr 444 25 of of IN cord-028721-x6f26ahr 444 26 Leydig Leydig NNP cord-028721-x6f26ahr 444 27 cell cell NN cord-028721-x6f26ahr 444 28 function function NN cord-028721-x6f26ahr 444 29 . . . cord-028721-x6f26ahr 445 1 Other other JJ cord-028721-x6f26ahr 445 2 secreted secrete VBN cord-028721-x6f26ahr 445 3 substances substance NNS cord-028721-x6f26ahr 445 4 include include VBP cord-028721-x6f26ahr 445 5 clusterin clusterin NNP cord-028721-x6f26ahr 445 6 , , , cord-028721-x6f26ahr 445 7 the the DT cord-028721-x6f26ahr 445 8 steroid steroid NN cord-028721-x6f26ahr 445 9 3-α-4-pregnen-20-one 3-α-4-pregnen-20-one CD cord-028721-x6f26ahr 445 10 ( ( -LRB- cord-028721-x6f26ahr 445 11 3HP 3hp CD cord-028721-x6f26ahr 445 12 ) ) -RRB- cord-028721-x6f26ahr 445 13 , , , cord-028721-x6f26ahr 445 14 and and CC cord-028721-x6f26ahr 445 15 prostaglandin prostaglandin NN cord-028721-x6f26ahr 445 16 D d NN cord-028721-x6f26ahr 445 17 synthase synthase NN cord-028721-x6f26ahr 446 1 ( ( -LRB- cord-028721-x6f26ahr 446 2 Table Table NNP cord-028721-x6f26ahr 446 3 12 12 CD cord-028721-x6f26ahr 446 4 - - SYM cord-028721-x6f26ahr 446 5 2 2 CD cord-028721-x6f26ahr 446 6 ) ) -RRB- cord-028721-x6f26ahr 446 7 . . . cord-028721-x6f26ahr 447 1 Sertoli sertoli JJ cord-028721-x6f26ahr 447 2 cells cell NNS cord-028721-x6f26ahr 447 3 are be VBP cord-028721-x6f26ahr 447 4 also also RB cord-028721-x6f26ahr 447 5 involved involve VBN cord-028721-x6f26ahr 447 6 in in IN cord-028721-x6f26ahr 447 7 migration migration NN cord-028721-x6f26ahr 447 8 of of IN cord-028721-x6f26ahr 447 9 differentiating differentiate VBG cord-028721-x6f26ahr 447 10 germ germ NN cord-028721-x6f26ahr 447 11 cells cell NNS cord-028721-x6f26ahr 447 12 towards towards IN cord-028721-x6f26ahr 447 13 the the DT cord-028721-x6f26ahr 447 14 tubular tubular JJ cord-028721-x6f26ahr 447 15 lumen lumen NN cord-028721-x6f26ahr 447 16 . . . cord-028721-x6f26ahr 448 1 This this DT cord-028721-x6f26ahr 448 2 movement movement NN cord-028721-x6f26ahr 448 3 leads lead VBZ cord-028721-x6f26ahr 448 4 to to IN cord-028721-x6f26ahr 448 5 a a DT cord-028721-x6f26ahr 448 6 continuous continuous JJ cord-028721-x6f26ahr 448 7 remodeling remodeling NN cord-028721-x6f26ahr 448 8 of of IN cord-028721-x6f26ahr 448 9 the the DT cord-028721-x6f26ahr 448 10 plasma plasma NN cord-028721-x6f26ahr 448 11 membrane membrane NN cord-028721-x6f26ahr 448 12 and and CC cord-028721-x6f26ahr 448 13 requires require VBZ cord-028721-x6f26ahr 448 14 synthesis synthesis NN cord-028721-x6f26ahr 448 15 of of IN cord-028721-x6f26ahr 448 16 several several JJ cord-028721-x6f26ahr 448 17 proteases protease NNS cord-028721-x6f26ahr 448 18 , , , cord-028721-x6f26ahr 448 19 including include VBG cord-028721-x6f26ahr 448 20 urokinase urokinase NN cord-028721-x6f26ahr 448 21 , , , cord-028721-x6f26ahr 448 22 tissue tissue NN cord-028721-x6f26ahr 448 23 - - HYPH cord-028721-x6f26ahr 448 24 type type NN cord-028721-x6f26ahr 448 25 plasminogen plasminogen NN cord-028721-x6f26ahr 448 26 activator activator NN cord-028721-x6f26ahr 448 27 , , , cord-028721-x6f26ahr 448 28 cyclic cyclic JJ cord-028721-x6f26ahr 448 29 protein protein NN cord-028721-x6f26ahr 448 30 2 2 CD cord-028721-x6f26ahr 448 31 , , , cord-028721-x6f26ahr 448 32 collagenase collagenase NNP cord-028721-x6f26ahr 448 33 IV IV NNP cord-028721-x6f26ahr 448 34 , , , cord-028721-x6f26ahr 448 35 other other JJ cord-028721-x6f26ahr 448 36 metalloproteins metalloprotein NNS cord-028721-x6f26ahr 448 37 , , , cord-028721-x6f26ahr 448 38 and and CC cord-028721-x6f26ahr 448 39 several several JJ cord-028721-x6f26ahr 448 40 antiproteases antiprotease NNS cord-028721-x6f26ahr 448 41 , , , cord-028721-x6f26ahr 448 42 such such JJ cord-028721-x6f26ahr 448 43 as as IN cord-028721-x6f26ahr 448 44 cystatin cystatin NNP cord-028721-x6f26ahr 448 45 C c NN cord-028721-x6f26ahr 448 46 , , , cord-028721-x6f26ahr 448 47 tissue tissue NN cord-028721-x6f26ahr 448 48 inhibitor inhibitor NN cord-028721-x6f26ahr 448 49 of of IN cord-028721-x6f26ahr 448 50 metalloproteinase metalloproteinase NN cord-028721-x6f26ahr 448 51 type type NN cord-028721-x6f26ahr 448 52 2 2 CD cord-028721-x6f26ahr 448 53 , , , cord-028721-x6f26ahr 448 54 and and CC cord-028721-x6f26ahr 448 55 α α NN cord-028721-x6f26ahr 448 56 2 2 CD cord-028721-x6f26ahr 448 57 -macroglobulin -macroglobulin CD cord-028721-x6f26ahr 448 58 . . . cord-028721-x6f26ahr 449 1 149 149 CD cord-028721-x6f26ahr 450 1 The the DT cord-028721-x6f26ahr 450 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 450 3 cell cell NN cord-028721-x6f26ahr 450 4 also also RB cord-028721-x6f26ahr 450 5 regulates regulate VBZ cord-028721-x6f26ahr 450 6 germ germ NN cord-028721-x6f26ahr 450 7 cell cell NN cord-028721-x6f26ahr 450 8 apoptosis apoptosis NN cord-028721-x6f26ahr 450 9 by by IN cord-028721-x6f26ahr 450 10 the the DT cord-028721-x6f26ahr 450 11 production production NN cord-028721-x6f26ahr 450 12 of of IN cord-028721-x6f26ahr 450 13 Fas Fas NNP cord-028721-x6f26ahr 450 14 - - HYPH cord-028721-x6f26ahr 450 15 ligand ligand NNP cord-028721-x6f26ahr 450 16 , , , cord-028721-x6f26ahr 450 17 which which WDT cord-028721-x6f26ahr 450 18 binds bind VBZ cord-028721-x6f26ahr 450 19 to to IN cord-028721-x6f26ahr 450 20 the the DT cord-028721-x6f26ahr 450 21 Fas Fas NNP cord-028721-x6f26ahr 450 22 - - HYPH cord-028721-x6f26ahr 450 23 ligand ligand NN cord-028721-x6f26ahr 450 24 receptor receptor NN cord-028721-x6f26ahr 450 25 ( ( -LRB- cord-028721-x6f26ahr 450 26 APO-1 APO-1 NNP cord-028721-x6f26ahr 450 27 , , , cord-028721-x6f26ahr 450 28 CD95 CD95 NNP cord-028721-x6f26ahr 450 29 ) ) -RRB- cord-028721-x6f26ahr 450 30 in in IN cord-028721-x6f26ahr 450 31 germ germ NN cord-028721-x6f26ahr 450 32 cell cell NN cord-028721-x6f26ahr 450 33 plasma plasma NN cord-028721-x6f26ahr 450 34 membranes membrane NNS cord-028721-x6f26ahr 450 35 . . . cord-028721-x6f26ahr 451 1 In in IN cord-028721-x6f26ahr 451 2 addition addition NN cord-028721-x6f26ahr 451 3 , , , cord-028721-x6f26ahr 451 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 451 5 cells cell NNS cord-028721-x6f26ahr 451 6 possess possess VBP cord-028721-x6f26ahr 451 7 receptors receptor NNS cord-028721-x6f26ahr 451 8 for for IN cord-028721-x6f26ahr 451 9 several several JJ cord-028721-x6f26ahr 451 10 factors factor NNS cord-028721-x6f26ahr 451 11 such such JJ cord-028721-x6f26ahr 451 12 as as IN cord-028721-x6f26ahr 451 13 the the DT cord-028721-x6f26ahr 451 14 nerve nerve NN cord-028721-x6f26ahr 451 15 growth growth NN cord-028721-x6f26ahr 451 16 factor factor NN cord-028721-x6f26ahr 451 17 ( ( -LRB- cord-028721-x6f26ahr 451 18 NGF NGF NNP cord-028721-x6f26ahr 451 19 ) ) -RRB- cord-028721-x6f26ahr 451 20 produced produce VBN cord-028721-x6f26ahr 451 21 by by IN cord-028721-x6f26ahr 451 22 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 451 23 and and CC cord-028721-x6f26ahr 451 24 young young JJ cord-028721-x6f26ahr 451 25 spermatids spermatid NNS cord-028721-x6f26ahr 451 26 , , , cord-028721-x6f26ahr 451 27 emphasizing emphasize VBG cord-028721-x6f26ahr 451 28 the the DT cord-028721-x6f26ahr 451 29 complexity complexity NN cord-028721-x6f26ahr 451 30 of of IN cord-028721-x6f26ahr 451 31 the the DT cord-028721-x6f26ahr 451 32 Sertoli sertoli JJ cord-028721-x6f26ahr 451 33 cell cell NN cord-028721-x6f26ahr 451 34 - - HYPH cord-028721-x6f26ahr 451 35 germ germ NN cord-028721-x6f26ahr 451 36 cell cell NN cord-028721-x6f26ahr 451 37 relationship relationship NN cord-028721-x6f26ahr 451 38 . . . cord-028721-x6f26ahr 452 1 Sertoli sertoli JJ cord-028721-x6f26ahr 452 2 cells cell NNS cord-028721-x6f26ahr 452 3 also also RB cord-028721-x6f26ahr 452 4 produce produce VBP cord-028721-x6f26ahr 452 5 some some DT cord-028721-x6f26ahr 452 6 steroid steroid NN cord-028721-x6f26ahr 452 7 hormones hormone NNS cord-028721-x6f26ahr 452 8 ( ( -LRB- cord-028721-x6f26ahr 452 9 estradiol estradiol NN cord-028721-x6f26ahr 452 10 and and CC cord-028721-x6f26ahr 452 11 testosterone testosterone NN cord-028721-x6f26ahr 452 12 ) ) -RRB- cord-028721-x6f26ahr 452 13 and and CC cord-028721-x6f26ahr 452 14 several several JJ cord-028721-x6f26ahr 452 15 components component NNS cord-028721-x6f26ahr 452 16 of of IN cord-028721-x6f26ahr 452 17 the the DT cord-028721-x6f26ahr 452 18 seminiferous seminiferous JJ cord-028721-x6f26ahr 452 19 tubule tubule NNP cord-028721-x6f26ahr 452 20 wall wall NN cord-028721-x6f26ahr 452 21 , , , cord-028721-x6f26ahr 452 22 including include VBG cord-028721-x6f26ahr 452 23 laminin laminin NN cord-028721-x6f26ahr 452 24 , , , cord-028721-x6f26ahr 452 25 type type NN cord-028721-x6f26ahr 452 26 IV IV NNP cord-028721-x6f26ahr 452 27 collagen collagen NN cord-028721-x6f26ahr 452 28 , , , cord-028721-x6f26ahr 452 29 and and CC cord-028721-x6f26ahr 452 30 heparin heparin NN cord-028721-x6f26ahr 452 31 sulfate sulfate NN cord-028721-x6f26ahr 452 32 - - HYPH cord-028721-x6f26ahr 452 33 rich rich JJ cord-028721-x6f26ahr 452 34 proteoglycans proteoglycan NNS cord-028721-x6f26ahr 452 35 . . . cord-028721-x6f26ahr 453 1 The the DT cord-028721-x6f26ahr 453 2 germ germ NN cord-028721-x6f26ahr 453 3 cells cell NNS cord-028721-x6f26ahr 453 4 of of IN cord-028721-x6f26ahr 453 5 the the DT cord-028721-x6f26ahr 453 6 adult adult NN cord-028721-x6f26ahr 453 7 testis testis NN cord-028721-x6f26ahr 453 8 include include VBP cord-028721-x6f26ahr 453 9 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 453 10 , , , cord-028721-x6f26ahr 453 11 primary primary JJ cord-028721-x6f26ahr 453 12 and and CC cord-028721-x6f26ahr 453 13 secondary secondary JJ cord-028721-x6f26ahr 453 14 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 453 15 , , , cord-028721-x6f26ahr 453 16 and and CC cord-028721-x6f26ahr 453 17 spermatids spermatids NNP cord-028721-x6f26ahr 453 18 . . . cord-028721-x6f26ahr 454 1 Spermatogonia Spermatogonia NNP cord-028721-x6f26ahr 454 2 There there EX cord-028721-x6f26ahr 454 3 are be VBP cord-028721-x6f26ahr 454 4 two two CD cord-028721-x6f26ahr 454 5 types type NNS cord-028721-x6f26ahr 454 6 of of IN cord-028721-x6f26ahr 454 7 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 454 8 : : : cord-028721-x6f26ahr 455 1 A A NNP cord-028721-x6f26ahr 455 2 and and CC cord-028721-x6f26ahr 455 3 B. B. NNP cord-028721-x6f26ahr 455 4 Type Type NNP cord-028721-x6f26ahr 455 5 A A NNP cord-028721-x6f26ahr 455 6 are be VBP cord-028721-x6f26ahr 455 7 about about RB cord-028721-x6f26ahr 455 8 12 12 CD cord-028721-x6f26ahr 455 9 µm µm NN cord-028721-x6f26ahr 455 10 in in IN cord-028721-x6f26ahr 455 11 diameter diameter NN cord-028721-x6f26ahr 455 12 , , , cord-028721-x6f26ahr 455 13 rest rest VB cord-028721-x6f26ahr 455 14 on on IN cord-028721-x6f26ahr 455 15 the the DT cord-028721-x6f26ahr 455 16 basal basal NN cord-028721-x6f26ahr 455 17 lamina lamina NN cord-028721-x6f26ahr 455 18 , , , cord-028721-x6f26ahr 455 19 and and CC cord-028721-x6f26ahr 455 20 are be VBP cord-028721-x6f26ahr 455 21 surrounded surround VBN cord-028721-x6f26ahr 455 22 by by IN cord-028721-x6f26ahr 455 23 the the DT cord-028721-x6f26ahr 455 24 cytoplasm cytoplasm NN cord-028721-x6f26ahr 455 25 of of IN cord-028721-x6f26ahr 455 26 the the DT cord-028721-x6f26ahr 455 27 adjacent adjacent JJ cord-028721-x6f26ahr 455 28 Sertoli Sertoli NNP cord-028721-x6f26ahr 455 29 cells cell NNS cord-028721-x6f26ahr 455 30 . . . cord-028721-x6f26ahr 456 1 The the DT cord-028721-x6f26ahr 456 2 nuclei nucleus NNS cord-028721-x6f26ahr 456 3 of of IN cord-028721-x6f26ahr 456 4 type type NN cord-028721-x6f26ahr 456 5 A a DT cord-028721-x6f26ahr 456 6 spermatogonia spermatogonia NN cord-028721-x6f26ahr 456 7 are be VBP cord-028721-x6f26ahr 456 8 spherical spherical JJ cord-028721-x6f26ahr 456 9 , , , cord-028721-x6f26ahr 456 10 contain contain VBP cord-028721-x6f26ahr 456 11 several several JJ cord-028721-x6f26ahr 456 12 peripheral peripheral JJ cord-028721-x6f26ahr 456 13 nucleoli nucleolus NNS cord-028721-x6f26ahr 456 14 , , , cord-028721-x6f26ahr 456 15 and and CC cord-028721-x6f26ahr 456 16 have have VBP cord-028721-x6f26ahr 456 17 four four CD cord-028721-x6f26ahr 456 18 different different JJ cord-028721-x6f26ahr 456 19 patterns pattern NNS cord-028721-x6f26ahr 456 20 : : : cord-028721-x6f26ahr 456 21 Ad ad NN cord-028721-x6f26ahr 456 22 ( ( -LRB- cord-028721-x6f26ahr 456 23 dark dark JJ cord-028721-x6f26ahr 456 24 ) ) -RRB- cord-028721-x6f26ahr 456 25 , , , cord-028721-x6f26ahr 456 26 Ap Ap NNP cord-028721-x6f26ahr 456 27 ( ( -LRB- cord-028721-x6f26ahr 456 28 pale pale NNP cord-028721-x6f26ahr 456 29 ) ) -RRB- cord-028721-x6f26ahr 456 30 , , , cord-028721-x6f26ahr 456 31 Al Al NNP cord-028721-x6f26ahr 456 32 ( ( -LRB- cord-028721-x6f26ahr 456 33 long long RB cord-028721-x6f26ahr 456 34 ) ) -RRB- cord-028721-x6f26ahr 456 35 , , , cord-028721-x6f26ahr 456 36 and and CC cord-028721-x6f26ahr 456 37 Ac Ac NNP cord-028721-x6f26ahr 456 38 ( ( -LRB- cord-028721-x6f26ahr 456 39 cloudy cloudy JJ cord-028721-x6f26ahr 456 40 ) ) -RRB- cord-028721-x6f26ahr 456 41 . . . cord-028721-x6f26ahr 457 1 150 150 CD cord-028721-x6f26ahr 457 2 , , , cord-028721-x6f26ahr 457 3 151 151 CD cord-028721-x6f26ahr 458 1 The the DT cord-028721-x6f26ahr 458 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 458 3 of of IN cord-028721-x6f26ahr 458 4 these these DT cord-028721-x6f26ahr 458 5 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 458 6 contains contain VBZ cord-028721-x6f26ahr 458 7 a a DT cord-028721-x6f26ahr 458 8 moderate moderate JJ cord-028721-x6f26ahr 458 9 number number NN cord-028721-x6f26ahr 458 10 of of IN cord-028721-x6f26ahr 458 11 ribosomes ribosome NNS cord-028721-x6f26ahr 458 12 , , , cord-028721-x6f26ahr 458 13 small small JJ cord-028721-x6f26ahr 458 14 ovoid ovoid JJ cord-028721-x6f26ahr 458 15 mitochondria mitochondrion NNS cord-028721-x6f26ahr 458 16 joined join VBN cord-028721-x6f26ahr 458 17 by by IN cord-028721-x6f26ahr 458 18 electron electron NN cord-028721-x6f26ahr 458 19 - - HYPH cord-028721-x6f26ahr 458 20 dense dense JJ cord-028721-x6f26ahr 458 21 bars bar NNS cord-028721-x6f26ahr 458 22 , , , cord-028721-x6f26ahr 458 23 and and CC cord-028721-x6f26ahr 458 24 Lubarsch Lubarsch NNP cord-028721-x6f26ahr 458 25 's 's POS cord-028721-x6f26ahr 458 26 crystals crystal NNS cord-028721-x6f26ahr 458 27 . . . cord-028721-x6f26ahr 459 1 These these DT cord-028721-x6f26ahr 459 2 are be VBP cord-028721-x6f26ahr 459 3 several several JJ cord-028721-x6f26ahr 459 4 micrometers micrometer NNS cord-028721-x6f26ahr 459 5 long long JJ cord-028721-x6f26ahr 459 6 and and CC cord-028721-x6f26ahr 459 7 are be VBP cord-028721-x6f26ahr 459 8 composed compose VBN cord-028721-x6f26ahr 459 9 of of IN cord-028721-x6f26ahr 459 10 numerous numerous JJ cord-028721-x6f26ahr 459 11 8 8 CD cord-028721-x6f26ahr 459 12 - - SYM cord-028721-x6f26ahr 459 13 15 15 CD cord-028721-x6f26ahr 459 14 nm nm NN cord-028721-x6f26ahr 459 15 parallel parallel JJ cord-028721-x6f26ahr 459 16 fi fi NNP cord-028721-x6f26ahr 459 17 laments lament NNS cord-028721-x6f26ahr 459 18 intermingled intermingle VBN cord-028721-x6f26ahr 459 19 with with IN cord-028721-x6f26ahr 459 20 ribosome ribosome NN cord-028721-x6f26ahr 459 21 - - HYPH cord-028721-x6f26ahr 459 22 like like JJ cord-028721-x6f26ahr 459 23 granules granule NNS cord-028721-x6f26ahr 459 24 . . . cord-028721-x6f26ahr 460 1 Ad Ad NNP cord-028721-x6f26ahr 460 2 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 460 3 are be VBP cord-028721-x6f26ahr 460 4 thought think VBN cord-028721-x6f26ahr 460 5 to to TO cord-028721-x6f26ahr 460 6 be be VB cord-028721-x6f26ahr 460 7 stem stem NN cord-028721-x6f26ahr 460 8 cells cell NNS cord-028721-x6f26ahr 460 9 in in IN cord-028721-x6f26ahr 460 10 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 460 11 . . . cord-028721-x6f26ahr 461 1 Some some DT cord-028721-x6f26ahr 461 2 of of IN cord-028721-x6f26ahr 461 3 them -PRON- PRP cord-028721-x6f26ahr 461 4 replicate replicate VBP cord-028721-x6f26ahr 461 5 DNA DNA NNP cord-028721-x6f26ahr 461 6 and and CC cord-028721-x6f26ahr 461 7 , , , cord-028721-x6f26ahr 461 8 during during IN cord-028721-x6f26ahr 461 9 replication replication NN cord-028721-x6f26ahr 461 10 , , , cord-028721-x6f26ahr 461 11 acquire acquire VB cord-028721-x6f26ahr 461 12 the the DT cord-028721-x6f26ahr 461 13 Al Al NNP cord-028721-x6f26ahr 461 14 pattern pattern NN cord-028721-x6f26ahr 461 15 . . . cord-028721-x6f26ahr 462 1 Afterwards afterwards RB cord-028721-x6f26ahr 462 2 , , , cord-028721-x6f26ahr 462 3 they -PRON- PRP cord-028721-x6f26ahr 462 4 divide divide VBP cord-028721-x6f26ahr 462 5 to to TO cord-028721-x6f26ahr 462 6 make make VB cord-028721-x6f26ahr 462 7 another another DT cord-028721-x6f26ahr 462 8 Ad ad NN cord-028721-x6f26ahr 462 9 ( ( -LRB- cord-028721-x6f26ahr 462 10 maintaining maintain VBG cord-028721-x6f26ahr 462 11 the the DT cord-028721-x6f26ahr 462 12 stem stem NN cord-028721-x6f26ahr 462 13 cell cell NN cord-028721-x6f26ahr 462 14 reservoir reservoir NN cord-028721-x6f26ahr 462 15 ) ) -RRB- cord-028721-x6f26ahr 462 16 and and CC cord-028721-x6f26ahr 462 17 an an DT cord-028721-x6f26ahr 462 18 Ap Ap NNP cord-028721-x6f26ahr 462 19 spermatogonium spermatogonium NN cord-028721-x6f26ahr 462 20 . . . cord-028721-x6f26ahr 463 1 During during IN cord-028721-x6f26ahr 463 2 replication replication NN cord-028721-x6f26ahr 463 3 , , , cord-028721-x6f26ahr 463 4 Ap Ap NNP cord-028721-x6f26ahr 463 5 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 463 6 become become VBP cord-028721-x6f26ahr 463 7 Ac Ac NNP cord-028721-x6f26ahr 463 8 and and CC cord-028721-x6f26ahr 463 9 then then RB cord-028721-x6f26ahr 463 10 divide divide VB cord-028721-x6f26ahr 463 11 to to TO cord-028721-x6f26ahr 463 12 form form VB cord-028721-x6f26ahr 463 13 two two CD cord-028721-x6f26ahr 463 14 type type NN cord-028721-x6f26ahr 463 15 B b NN cord-028721-x6f26ahr 463 16 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 463 17 . . . cord-028721-x6f26ahr 464 1 [ [ -LRB- cord-028721-x6f26ahr 464 2 152 152 CD cord-028721-x6f26ahr 464 3 ] ] -RRB- cord-028721-x6f26ahr 464 4 [ [ -LRB- cord-028721-x6f26ahr 464 5 153 153 CD cord-028721-x6f26ahr 464 6 ] ] -RRB- cord-028721-x6f26ahr 465 1 [ [ -LRB- cord-028721-x6f26ahr 465 2 154 154 CD cord-028721-x6f26ahr 465 3 ] ] -RRB- cord-028721-x6f26ahr 465 4 Type type NN cord-028721-x6f26ahr 465 5 B b NN cord-028721-x6f26ahr 465 6 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 465 7 are be VBP cord-028721-x6f26ahr 465 8 the the DT cord-028721-x6f26ahr 465 9 most most RBS cord-028721-x6f26ahr 465 10 numerous numerous JJ cord-028721-x6f26ahr 465 11 , , , cord-028721-x6f26ahr 465 12 and and CC cord-028721-x6f26ahr 465 13 their -PRON- PRP$ cord-028721-x6f26ahr 465 14 contact contact NN cord-028721-x6f26ahr 465 15 with with IN cord-028721-x6f26ahr 465 16 the the DT cord-028721-x6f26ahr 465 17 basal basal NN cord-028721-x6f26ahr 465 18 lamina lamina NN cord-028721-x6f26ahr 465 19 is be VBZ cord-028721-x6f26ahr 465 20 less less RBR cord-028721-x6f26ahr 465 21 extensive extensive JJ cord-028721-x6f26ahr 465 22 than than IN cord-028721-x6f26ahr 465 23 that that DT cord-028721-x6f26ahr 465 24 of of IN cord-028721-x6f26ahr 465 25 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 465 26 studies study NNS cord-028721-x6f26ahr 465 27 show show VBP cord-028721-x6f26ahr 465 28 coarse coarse JJ cord-028721-x6f26ahr 465 29 chromatin chromatin NN cord-028721-x6f26ahr 465 30 masses masse NNS cord-028721-x6f26ahr 465 31 in in IN cord-028721-x6f26ahr 465 32 which which WDT cord-028721-x6f26ahr 465 33 synaptonemal synaptonemal NNP cord-028721-x6f26ahr 465 34 complexes complex NNS cord-028721-x6f26ahr 465 35 and and CC cord-028721-x6f26ahr 465 36 sex sex NN cord-028721-x6f26ahr 465 37 pairs pair NNS cord-028721-x6f26ahr 465 38 may may MD cord-028721-x6f26ahr 465 39 be be VB cord-028721-x6f26ahr 465 40 present present JJ cord-028721-x6f26ahr 465 41 . . . cord-028721-x6f26ahr 466 1 The the DT cord-028721-x6f26ahr 466 2 nucleolus nucleolus NN cord-028721-x6f26ahr 466 3 acquires acquire VBZ cord-028721-x6f26ahr 466 4 a a DT cord-028721-x6f26ahr 466 5 peculiar peculiar JJ cord-028721-x6f26ahr 466 6 appearance appearance NN cord-028721-x6f26ahr 466 7 , , , cord-028721-x6f26ahr 466 8 with with IN cord-028721-x6f26ahr 466 9 segregation segregation NN cord-028721-x6f26ahr 466 10 of of IN cord-028721-x6f26ahr 466 11 the the DT cord-028721-x6f26ahr 466 12 fi fi NN cord-028721-x6f26ahr 466 13 brillar brillar NNP cord-028721-x6f26ahr 466 14 and and CC cord-028721-x6f26ahr 466 15 granular granular JJ cord-028721-x6f26ahr 466 16 portions portion NNS cord-028721-x6f26ahr 466 17 . . . cord-028721-x6f26ahr 467 1 Associated associate VBN cord-028721-x6f26ahr 467 2 with with IN cord-028721-x6f26ahr 467 3 the the DT cord-028721-x6f26ahr 467 4 nucleolus nucleolus NN cord-028721-x6f26ahr 467 5 is be VBZ cord-028721-x6f26ahr 467 6 the the DT cord-028721-x6f26ahr 467 7 round round JJ cord-028721-x6f26ahr 467 8 body body NN cord-028721-x6f26ahr 467 9 that that WDT cord-028721-x6f26ahr 467 10 contains contain VBZ cord-028721-x6f26ahr 467 11 proteins protein NNS cord-028721-x6f26ahr 467 12 but but CC cord-028721-x6f26ahr 467 13 no no DT cord-028721-x6f26ahr 467 14 nucleic nucleic JJ cord-028721-x6f26ahr 467 15 acids acid NNS cord-028721-x6f26ahr 467 16 . . . cord-028721-x6f26ahr 468 1 128 128 CD cord-028721-x6f26ahr 469 1 In in IN cord-028721-x6f26ahr 469 2 the the DT cord-028721-x6f26ahr 469 3 pachytene pachytene NN cord-028721-x6f26ahr 469 4 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 469 5 , , , cord-028721-x6f26ahr 469 6 homologous homologous JJ cord-028721-x6f26ahr 469 7 chromosomes chromosome NNS cord-028721-x6f26ahr 469 8 are be VBP cord-028721-x6f26ahr 469 9 completely completely RB cord-028721-x6f26ahr 469 10 paired pair VBN cord-028721-x6f26ahr 469 11 , , , cord-028721-x6f26ahr 469 12 and and CC cord-028721-x6f26ahr 469 13 on on IN cord-028721-x6f26ahr 469 14 electron electron NN cord-028721-x6f26ahr 469 15 microscopy microscopy VBP cord-028721-x6f26ahr 469 16 the the DT cord-028721-x6f26ahr 469 17 chromatin chromatin NN cord-028721-x6f26ahr 469 18 masses masse NNS cord-028721-x6f26ahr 469 19 appear appear VBP cord-028721-x6f26ahr 469 20 larger large JJR cord-028721-x6f26ahr 469 21 and and CC cord-028721-x6f26ahr 469 22 less less RBR cord-028721-x6f26ahr 469 23 numerous numerous JJ cord-028721-x6f26ahr 469 24 than than IN cord-028721-x6f26ahr 469 25 in in IN cord-028721-x6f26ahr 469 26 the the DT cord-028721-x6f26ahr 469 27 zygotene zygotene NNP cord-028721-x6f26ahr 469 28 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 469 29 . . . cord-028721-x6f26ahr 470 1 In in IN cord-028721-x6f26ahr 470 2 the the DT cord-028721-x6f26ahr 470 3 diplotene diplotene JJ cord-028721-x6f26ahr 470 4 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 470 5 , , , cord-028721-x6f26ahr 470 6 paired pair VBN cord-028721-x6f26ahr 470 7 homologous homologous JJ cord-028721-x6f26ahr 470 8 chromosomes chromosome NNS cord-028721-x6f26ahr 470 9 begin begin VBP cord-028721-x6f26ahr 470 10 to to TO cord-028721-x6f26ahr 470 11 separate separate VB cord-028721-x6f26ahr 470 12 and and CC cord-028721-x6f26ahr 470 13 remain remain VB cord-028721-x6f26ahr 470 14 joined join VBN cord-028721-x6f26ahr 470 15 by by IN cord-028721-x6f26ahr 470 16 the the DT cord-028721-x6f26ahr 470 17 points point NNS cord-028721-x6f26ahr 470 18 of of IN cord-028721-x6f26ahr 470 19 interchange interchange NN cord-028721-x6f26ahr 470 20 ( ( -LRB- cord-028721-x6f26ahr 470 21 chiasmata chiasmata NNP cord-028721-x6f26ahr 470 22 ) ) -RRB- cord-028721-x6f26ahr 470 23 ; ; : cord-028721-x6f26ahr 470 24 neither neither CC cord-028721-x6f26ahr 470 25 synaptonemal synaptonemal NNP cord-028721-x6f26ahr 470 26 complexes complex NNS cord-028721-x6f26ahr 470 27 nor nor CC cord-028721-x6f26ahr 470 28 sex sex NN cord-028721-x6f26ahr 470 29 pairs pair NNS cord-028721-x6f26ahr 470 30 are be VBP cord-028721-x6f26ahr 470 31 observed observe VBN cord-028721-x6f26ahr 470 32 . . . cord-028721-x6f26ahr 471 1 The the DT cord-028721-x6f26ahr 471 2 diakinesis diakinesis NN cord-028721-x6f26ahr 471 3 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 471 4 shows show VBZ cord-028721-x6f26ahr 471 5 maximal maximal JJ cord-028721-x6f26ahr 471 6 chromosome chromosome NN cord-028721-x6f26ahr 471 7 shortening shortening NN cord-028721-x6f26ahr 471 8 and and CC cord-028721-x6f26ahr 471 9 the the DT cord-028721-x6f26ahr 471 10 chiasmata chiasma NNS cord-028721-x6f26ahr 471 11 begin begin VBP cord-028721-x6f26ahr 471 12 to to TO cord-028721-x6f26ahr 471 13 resolve resolve VB cord-028721-x6f26ahr 471 14 by by IN cord-028721-x6f26ahr 471 15 displacement displacement NN cord-028721-x6f26ahr 471 16 towards towards IN cord-028721-x6f26ahr 471 17 the the DT cord-028721-x6f26ahr 471 18 chromosomal chromosomal JJ cord-028721-x6f26ahr 471 19 ends end NNS cord-028721-x6f26ahr 471 20 . . . cord-028721-x6f26ahr 472 1 The the DT cord-028721-x6f26ahr 472 2 nuclear nuclear JJ cord-028721-x6f26ahr 472 3 envelope envelope NN cord-028721-x6f26ahr 472 4 and and CC cord-028721-x6f26ahr 472 5 the the DT cord-028721-x6f26ahr 472 6 nucleolus nucleolus NN cord-028721-x6f26ahr 472 7 disintegrate disintegrate VBP cord-028721-x6f26ahr 472 8 . . . cord-028721-x6f26ahr 473 1 The the DT cord-028721-x6f26ahr 473 2 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 473 3 completes complete VBZ cord-028721-x6f26ahr 473 4 the the DT cord-028721-x6f26ahr 473 5 other other JJ cord-028721-x6f26ahr 473 6 phases phase NNS cord-028721-x6f26ahr 473 7 of of IN cord-028721-x6f26ahr 473 8 the the DT cord-028721-x6f26ahr 473 9 fi fi NNP cord-028721-x6f26ahr 473 10 rst rst NNP cord-028721-x6f26ahr 473 11 meiotic meiotic JJ cord-028721-x6f26ahr 473 12 division division NN cord-028721-x6f26ahr 473 13 ( ( -LRB- cord-028721-x6f26ahr 473 14 metaphase metaphase NN cord-028721-x6f26ahr 473 15 , , , cord-028721-x6f26ahr 473 16 anaphase anaphase VB cord-028721-x6f26ahr 473 17 and and CC cord-028721-x6f26ahr 473 18 telophase telophase NN cord-028721-x6f26ahr 473 19 ) ) -RRB- cord-028721-x6f26ahr 473 20 , , , cord-028721-x6f26ahr 473 21 forming form VBG cord-028721-x6f26ahr 473 22 two two CD cord-028721-x6f26ahr 473 23 secondary secondary JJ cord-028721-x6f26ahr 473 24 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 473 25 ; ; : cord-028721-x6f26ahr 473 26 the the DT cord-028721-x6f26ahr 473 27 fi fi NNP cord-028721-x6f26ahr 473 28 rst rst NNP cord-028721-x6f26ahr 473 29 meiotic meiotic JJ cord-028721-x6f26ahr 473 30 division division NN cord-028721-x6f26ahr 473 31 lasts last VBZ cord-028721-x6f26ahr 473 32 24 24 CD cord-028721-x6f26ahr 473 33 days day NNS cord-028721-x6f26ahr 473 34 . . . cord-028721-x6f26ahr 474 1 156 156 CD cord-028721-x6f26ahr 474 2 Secondary secondary JJ cord-028721-x6f26ahr 474 3 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 474 4 are be VBP cord-028721-x6f26ahr 474 5 haploid haploid JJ cord-028721-x6f26ahr 474 6 cells cell NNS cord-028721-x6f26ahr 474 7 , , , cord-028721-x6f26ahr 474 8 smaller small JJR cord-028721-x6f26ahr 474 9 than than IN cord-028721-x6f26ahr 474 10 primary primary JJ cord-028721-x6f26ahr 474 11 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 474 12 , , , cord-028721-x6f26ahr 474 13 and and CC cord-028721-x6f26ahr 474 14 show show VBP cord-028721-x6f26ahr 474 15 coarse coarse JJ cord-028721-x6f26ahr 474 16 chromatin chromatin NN cord-028721-x6f26ahr 474 17 granules granule NNS cord-028721-x6f26ahr 474 18 and and CC cord-028721-x6f26ahr 474 19 abundant abundant JJ cord-028721-x6f26ahr 474 20 rough rough JJ cord-028721-x6f26ahr 474 21 endoplasmic endoplasmic NN cord-028721-x6f26ahr 474 22 reticulum reticulum NN cord-028721-x6f26ahr 474 23 cisternae cisternae NNP cord-028721-x6f26ahr 474 24 . . . cord-028721-x6f26ahr 475 1 157 157 CD cord-028721-x6f26ahr 476 1 These these DT cord-028721-x6f26ahr 476 2 cells cell NNS cord-028721-x6f26ahr 476 3 rapidly rapidly RB cord-028721-x6f26ahr 476 4 undergo undergo VBP cord-028721-x6f26ahr 476 5 the the DT cord-028721-x6f26ahr 476 6 second second JJ cord-028721-x6f26ahr 476 7 meiotic meiotic JJ cord-028721-x6f26ahr 476 8 division division NN cord-028721-x6f26ahr 476 9 and and CC cord-028721-x6f26ahr 476 10 within within IN cord-028721-x6f26ahr 476 11 8 8 CD cord-028721-x6f26ahr 476 12 hours hour NNS cord-028721-x6f26ahr 476 13 give give VBP cord-028721-x6f26ahr 476 14 rise rise NN cord-028721-x6f26ahr 476 15 to to IN cord-028721-x6f26ahr 476 16 two two CD cord-028721-x6f26ahr 476 17 spermatids spermatid NNS cord-028721-x6f26ahr 476 18 . . . cord-028721-x6f26ahr 477 1 The the DT cord-028721-x6f26ahr 477 2 newly newly RB cord-028721-x6f26ahr 477 3 formed form VBN cord-028721-x6f26ahr 477 4 spermatids spermatid NNS cord-028721-x6f26ahr 477 5 differ differ VBP cord-028721-x6f26ahr 477 6 from from IN cord-028721-x6f26ahr 477 7 secondary secondary JJ cord-028721-x6f26ahr 477 8 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 477 9 , , , cord-028721-x6f26ahr 477 10 having have VBG cord-028721-x6f26ahr 477 11 smaller small JJR cord-028721-x6f26ahr 477 12 nuclei nucleus NNS cord-028721-x6f26ahr 477 13 with with IN cord-028721-x6f26ahr 477 14 homogeneously homogeneously RB cord-028721-x6f26ahr 477 15 distributed distribute VBN cord-028721-x6f26ahr 477 16 chromatin chromatin NN cord-028721-x6f26ahr 477 17 . . . cord-028721-x6f26ahr 478 1 Spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 479 1 The the DT cord-028721-x6f26ahr 479 2 transformation transformation NN cord-028721-x6f26ahr 479 3 of of IN cord-028721-x6f26ahr 479 4 spermatids spermatid NNS cord-028721-x6f26ahr 479 5 into into IN cord-028721-x6f26ahr 479 6 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 479 7 is be VBZ cord-028721-x6f26ahr 479 8 called call VBN cord-028721-x6f26ahr 479 9 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 479 10 . . . cord-028721-x6f26ahr 480 1 During during IN cord-028721-x6f26ahr 480 2 this this DT cord-028721-x6f26ahr 480 3 process process NN cord-028721-x6f26ahr 480 4 pronounced pronounce VBN cord-028721-x6f26ahr 480 5 changes change NNS cord-028721-x6f26ahr 480 6 occur occur VBP cord-028721-x6f26ahr 480 7 in in IN cord-028721-x6f26ahr 480 8 the the DT cord-028721-x6f26ahr 480 9 nucleus nucleus NN cord-028721-x6f26ahr 480 10 and and CC cord-028721-x6f26ahr 480 11 cytoplasm cytoplasm JJ cord-028721-x6f26ahr 480 12 . . . cord-028721-x6f26ahr 481 1 158 158 CD cord-028721-x6f26ahr 482 1 The the DT cord-028721-x6f26ahr 482 2 nucleus nucleus NN cord-028721-x6f26ahr 482 3 becomes become VBZ cord-028721-x6f26ahr 482 4 progressively progressively RB cord-028721-x6f26ahr 482 5 darker dark JJR cord-028721-x6f26ahr 482 6 and and CC cord-028721-x6f26ahr 482 7 elongated elongated JJ cord-028721-x6f26ahr 482 8 . . . cord-028721-x6f26ahr 483 1 159 159 CD cord-028721-x6f26ahr 484 1 The the DT cord-028721-x6f26ahr 484 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 484 3 develops develop VBZ cord-028721-x6f26ahr 484 4 the the DT cord-028721-x6f26ahr 484 5 acrosome acrosome NN cord-028721-x6f26ahr 484 6 and and CC cord-028721-x6f26ahr 484 7 fl fl NNP cord-028721-x6f26ahr 484 8 agellum agellum NNP cord-028721-x6f26ahr 484 9 , , , cord-028721-x6f26ahr 485 1 160 160 CD cord-028721-x6f26ahr 485 2 the the DT cord-028721-x6f26ahr 485 3 mitochondria mitochondrion NNS cord-028721-x6f26ahr 485 4 cluster cluster NN cord-028721-x6f26ahr 485 5 around around IN cord-028721-x6f26ahr 485 6 the the DT cord-028721-x6f26ahr 485 7 fi fi NN cord-028721-x6f26ahr 485 8 rst rst NN cord-028721-x6f26ahr 485 9 portion portion NN cord-028721-x6f26ahr 485 10 of of IN cord-028721-x6f26ahr 485 11 the the DT cord-028721-x6f26ahr 485 12 spermatozoon spermatozoon NN cord-028721-x6f26ahr 485 13 tail tail NN cord-028721-x6f26ahr 485 14 , , , cord-028721-x6f26ahr 485 15 and and CC cord-028721-x6f26ahr 485 16 the the DT cord-028721-x6f26ahr 485 17 remaining remain VBG cord-028721-x6f26ahr 485 18 cytoplasm cytoplasm NN cord-028721-x6f26ahr 485 19 is be VBZ cord-028721-x6f26ahr 485 20 phagocytosed phagocytose VBN cord-028721-x6f26ahr 485 21 by by IN cord-028721-x6f26ahr 485 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 485 23 cells cell NNS cord-028721-x6f26ahr 485 24 . . . cord-028721-x6f26ahr 486 1 161 161 CD cord-028721-x6f26ahr 486 2 , , , cord-028721-x6f26ahr 486 3 162 162 CD cord-028721-x6f26ahr 487 1 By by IN cord-028721-x6f26ahr 487 2 electron electron NN cord-028721-x6f26ahr 487 3 microscopy microscopy NNS cord-028721-x6f26ahr 487 4 , , , cord-028721-x6f26ahr 487 5 there there EX cord-028721-x6f26ahr 487 6 are be VBP cord-028721-x6f26ahr 487 7 four four CD cord-028721-x6f26ahr 487 8 tran tran JJ cord-028721-x6f26ahr 487 9 - - HYPH cord-028721-x6f26ahr 487 10 sient sient NN cord-028721-x6f26ahr 487 11 stages stage NNS cord-028721-x6f26ahr 487 12 of of IN cord-028721-x6f26ahr 487 13 spermatid spermatid NNP cord-028721-x6f26ahr 487 14 development development NN cord-028721-x6f26ahr 487 15 : : : cord-028721-x6f26ahr 487 16 Golgi Golgi NNP cord-028721-x6f26ahr 487 17 , , , cord-028721-x6f26ahr 487 18 cap cap NN cord-028721-x6f26ahr 487 19 , , , cord-028721-x6f26ahr 487 20 acrosome acrosome NN cord-028721-x6f26ahr 487 21 , , , cord-028721-x6f26ahr 487 22 and and CC cord-028721-x6f26ahr 487 23 maturation maturation NN cord-028721-x6f26ahr 487 24 . . . cord-028721-x6f26ahr 488 1 These these DT cord-028721-x6f26ahr 488 2 correspond correspond VBP cord-028721-x6f26ahr 488 3 to to IN cord-028721-x6f26ahr 488 4 those those DT cord-028721-x6f26ahr 488 5 defi defi NNP cord-028721-x6f26ahr 488 6 ned ned NNP cord-028721-x6f26ahr 488 7 by by IN cord-028721-x6f26ahr 488 8 light light JJ cord-028721-x6f26ahr 488 9 microscopy microscopy NNS cord-028721-x6f26ahr 488 10 of of IN cord-028721-x6f26ahr 488 11 nuclear nuclear JJ cord-028721-x6f26ahr 488 12 morphology morphology NN cord-028721-x6f26ahr 488 13 : : : cord-028721-x6f26ahr 488 14 Sa Sa NNP cord-028721-x6f26ahr 488 15 , , , cord-028721-x6f26ahr 488 16 Sb Sb NNP cord-028721-x6f26ahr 488 17 , , , cord-028721-x6f26ahr 488 18 Sb Sb NNP cord-028721-x6f26ahr 488 19 1 1 CD cord-028721-x6f26ahr 488 20 , , , cord-028721-x6f26ahr 488 21 Sb Sb NNP cord-028721-x6f26ahr 488 22 2 2 CD cord-028721-x6f26ahr 488 23 , , , cord-028721-x6f26ahr 488 24 Sc Sc NNP cord-028721-x6f26ahr 488 25 , , , cord-028721-x6f26ahr 488 26 Sd Sd NNP cord-028721-x6f26ahr 488 27 1 1 CD cord-028721-x6f26ahr 488 28 and and CC cord-028721-x6f26ahr 488 29 Sd Sd NNP cord-028721-x6f26ahr 488 30 2 2 CD cord-028721-x6f26ahr 488 31 . . . cord-028721-x6f26ahr 488 32 163 163 CD cord-028721-x6f26ahr 488 33 , , , cord-028721-x6f26ahr 488 34 164 164 CD cord-028721-x6f26ahr 489 1 These these DT cord-028721-x6f26ahr 489 2 phases phase NNS cord-028721-x6f26ahr 489 3 may may MD cord-028721-x6f26ahr 489 4 be be VB cord-028721-x6f26ahr 489 5 grouped group VBN cord-028721-x6f26ahr 489 6 as as RB cord-028721-x6f26ahr 489 7 early early JJ cord-028721-x6f26ahr 489 8 ( ( -LRB- cord-028721-x6f26ahr 489 9 or or CC cord-028721-x6f26ahr 489 10 round round JJ cord-028721-x6f26ahr 489 11 ) ) -RRB- cord-028721-x6f26ahr 489 12 spermatids spermatid NNS cord-028721-x6f26ahr 489 13 that that WDT cord-028721-x6f26ahr 489 14 comprise comprise VBP cord-028721-x6f26ahr 489 15 the the DT cord-028721-x6f26ahr 489 16 stages stage NNS cord-028721-x6f26ahr 489 17 with with IN cord-028721-x6f26ahr 489 18 round round JJ cord-028721-x6f26ahr 489 19 nuclei nucleus NNS cord-028721-x6f26ahr 489 20 ( ( -LRB- cord-028721-x6f26ahr 489 21 Sa Sa NNP cord-028721-x6f26ahr 489 22 and and CC cord-028721-x6f26ahr 489 23 Sb Sb NNP cord-028721-x6f26ahr 489 24 ) ) -RRB- cord-028721-x6f26ahr 489 25 , , , cord-028721-x6f26ahr 489 26 and and CC cord-028721-x6f26ahr 489 27 as as IN cord-028721-x6f26ahr 489 28 late late JJ cord-028721-x6f26ahr 489 29 ( ( -LRB- cord-028721-x6f26ahr 489 30 or or CC cord-028721-x6f26ahr 489 31 elongated elongated JJ cord-028721-x6f26ahr 489 32 ) ) -RRB- cord-028721-x6f26ahr 489 33 spermatids spermatid NNS cord-028721-x6f26ahr 489 34 that that WDT cord-028721-x6f26ahr 489 35 comprise comprise VBP cord-028721-x6f26ahr 489 36 the the DT cord-028721-x6f26ahr 489 37 stages stage NNS cord-028721-x6f26ahr 489 38 with with IN cord-028721-x6f26ahr 489 39 elongated elongated JJ cord-028721-x6f26ahr 489 40 nuclei nucleus NNS cord-028721-x6f26ahr 489 41 ( ( -LRB- cord-028721-x6f26ahr 489 42 Sc Sc NNP cord-028721-x6f26ahr 489 43 and and CC cord-028721-x6f26ahr 489 44 Sd Sd NNP cord-028721-x6f26ahr 489 45 ) ) -RRB- cord-028721-x6f26ahr 489 46 . . . cord-028721-x6f26ahr 490 1 Mature mature JJ cord-028721-x6f26ahr 490 2 spermatids spermatid NNS cord-028721-x6f26ahr 490 3 ( ( -LRB- cord-028721-x6f26ahr 490 4 Sd Sd NNP cord-028721-x6f26ahr 490 5 2 2 CD cord-028721-x6f26ahr 490 6 ) ) -RRB- cord-028721-x6f26ahr 490 7 are be VBP cord-028721-x6f26ahr 490 8 the the DT cord-028721-x6f26ahr 490 9 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 490 10 that that WDT cord-028721-x6f26ahr 490 11 are be VBP cord-028721-x6f26ahr 490 12 released release VBN cord-028721-x6f26ahr 490 13 into into IN cord-028721-x6f26ahr 490 14 the the DT cord-028721-x6f26ahr 490 15 tubular tubular JJ cord-028721-x6f26ahr 490 16 lumen lumen NN cord-028721-x6f26ahr 490 17 ( ( -LRB- cord-028721-x6f26ahr 490 18 spermiation spermiation NNP cord-028721-x6f26ahr 490 19 ) ) -RRB- cord-028721-x6f26ahr 490 20 . . . cord-028721-x6f26ahr 491 1 All all PDT cord-028721-x6f26ahr 491 2 the the DT cord-028721-x6f26ahr 491 3 germ germ NN cord-028721-x6f26ahr 491 4 cells cell NNS cord-028721-x6f26ahr 491 5 derived derive VBN cord-028721-x6f26ahr 491 6 from from IN cord-028721-x6f26ahr 491 7 the the DT cord-028721-x6f26ahr 491 8 same same JJ cord-028721-x6f26ahr 491 9 stem stem NN cord-028721-x6f26ahr 491 10 cell cell NN cord-028721-x6f26ahr 491 11 remain remain VBP cord-028721-x6f26ahr 491 12 interconnected interconnect VBN cord-028721-x6f26ahr 491 13 by by IN cord-028721-x6f26ahr 491 14 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 491 15 bridges bridge NNS cord-028721-x6f26ahr 491 16 that that WDT cord-028721-x6f26ahr 491 17 ensure ensure VBP cord-028721-x6f26ahr 491 18 synchronous synchronous JJ cord-028721-x6f26ahr 491 19 maturation maturation NN cord-028721-x6f26ahr 491 20 during during IN cord-028721-x6f26ahr 491 21 the the DT cord-028721-x6f26ahr 491 22 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 491 23 process process NN cord-028721-x6f26ahr 491 24 . . . cord-028721-x6f26ahr 492 1 165 165 CD cord-028721-x6f26ahr 492 2 Cycle cycle NN cord-028721-x6f26ahr 492 3 of of IN cord-028721-x6f26ahr 492 4 the the DT cord-028721-x6f26ahr 492 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 492 6 epithelium epithelium NN cord-028721-x6f26ahr 492 7 At at IN cord-028721-x6f26ahr 492 8 fi fi NN cord-028721-x6f26ahr 492 9 rst rst NN cord-028721-x6f26ahr 492 10 glance glance NN cord-028721-x6f26ahr 492 11 , , , cord-028721-x6f26ahr 492 12 the the DT cord-028721-x6f26ahr 492 13 arrangement arrangement NN cord-028721-x6f26ahr 492 14 of of IN cord-028721-x6f26ahr 492 15 the the DT cord-028721-x6f26ahr 492 16 germ germ NN cord-028721-x6f26ahr 492 17 cells cell NNS cord-028721-x6f26ahr 492 18 in in IN cord-028721-x6f26ahr 492 19 the the DT cord-028721-x6f26ahr 492 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 492 21 tubules tubule NNS cord-028721-x6f26ahr 492 22 appears appear VBZ cord-028721-x6f26ahr 492 23 disorderly disorderly JJ cord-028721-x6f26ahr 492 24 . . . cord-028721-x6f26ahr 493 1 However however RB cord-028721-x6f26ahr 493 2 , , , cord-028721-x6f26ahr 493 3 closer close JJR cord-028721-x6f26ahr 493 4 study study NN cord-028721-x6f26ahr 493 5 reveals reveal VBZ cord-028721-x6f26ahr 493 6 that that IN cord-028721-x6f26ahr 493 7 these these DT cord-028721-x6f26ahr 493 8 cells cell NNS cord-028721-x6f26ahr 493 9 are be VBP cord-028721-x6f26ahr 493 10 grouped group VBN cord-028721-x6f26ahr 493 11 into into IN cord-028721-x6f26ahr 493 12 six six CD cord-028721-x6f26ahr 493 13 successive successive JJ cord-028721-x6f26ahr 493 14 associations association NNS cord-028721-x6f26ahr 493 15 , , , cord-028721-x6f26ahr 493 16 designated designate VBN cord-028721-x6f26ahr 493 17 I I NNP cord-028721-x6f26ahr 493 18 - - HYPH cord-028721-x6f26ahr 493 19 VI VI NNP cord-028721-x6f26ahr 493 20 . . . cord-028721-x6f26ahr 494 1 In in IN cord-028721-x6f26ahr 494 2 contrast contrast NN cord-028721-x6f26ahr 494 3 to to IN cord-028721-x6f26ahr 494 4 other other JJ cord-028721-x6f26ahr 494 5 mammals mammal NNS cord-028721-x6f26ahr 494 6 , , , cord-028721-x6f26ahr 494 7 in in IN cord-028721-x6f26ahr 494 8 humans human NNS cord-028721-x6f26ahr 494 9 the the DT cord-028721-x6f26ahr 494 10 volume volume NN cord-028721-x6f26ahr 494 11 occupied occupy VBN cord-028721-x6f26ahr 494 12 by by IN cord-028721-x6f26ahr 494 13 each each DT cord-028721-x6f26ahr 494 14 association association NN cord-028721-x6f26ahr 494 15 is be VBZ cord-028721-x6f26ahr 494 16 small small JJ cord-028721-x6f26ahr 494 17 , , , cord-028721-x6f26ahr 494 18 so so IN cord-028721-x6f26ahr 494 19 that that IN cord-028721-x6f26ahr 494 20 several several JJ cord-028721-x6f26ahr 494 21 associations association NNS cord-028721-x6f26ahr 494 22 may may MD cord-028721-x6f26ahr 494 23 be be VB cord-028721-x6f26ahr 494 24 observed observe VBN cord-028721-x6f26ahr 494 25 in in IN cord-028721-x6f26ahr 494 26 the the DT cord-028721-x6f26ahr 494 27 same same JJ cord-028721-x6f26ahr 494 28 tubular tubular JJ cord-028721-x6f26ahr 494 29 cross cross NN cord-028721-x6f26ahr 494 30 - - NN cord-028721-x6f26ahr 494 31 section section NN cord-028721-x6f26ahr 494 32 . . . cord-028721-x6f26ahr 495 1 Stereological stereological JJ cord-028721-x6f26ahr 495 2 studies study NNS cord-028721-x6f26ahr 495 3 have have VBP cord-028721-x6f26ahr 495 4 shown show VBN cord-028721-x6f26ahr 495 5 that that IN cord-028721-x6f26ahr 495 6 the the DT cord-028721-x6f26ahr 495 7 successive successive JJ cord-028721-x6f26ahr 495 8 associations association NNS cord-028721-x6f26ahr 495 9 are be VBP cord-028721-x6f26ahr 495 10 organized organize VBN cord-028721-x6f26ahr 495 11 helically helically RB cord-028721-x6f26ahr 495 12 along along IN cord-028721-x6f26ahr 495 13 the the DT cord-028721-x6f26ahr 495 14 length length NN cord-028721-x6f26ahr 495 15 of of IN cord-028721-x6f26ahr 495 16 the the DT cord-028721-x6f26ahr 495 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 495 18 tubule tubule NNP cord-028721-x6f26ahr 495 19 . . . cord-028721-x6f26ahr 496 1 126 126 CD cord-028721-x6f26ahr 496 2 , , , cord-028721-x6f26ahr 496 3 [ [ -LRB- cord-028721-x6f26ahr 496 4 165 165 CD cord-028721-x6f26ahr 496 5 ] ] -RRB- cord-028721-x6f26ahr 496 6 [ [ -LRB- cord-028721-x6f26ahr 496 7 166 166 CD cord-028721-x6f26ahr 496 8 ] ] -RRB- cord-028721-x6f26ahr 497 1 [ [ -LRB- cord-028721-x6f26ahr 497 2 167 167 CD cord-028721-x6f26ahr 497 3 ] ] -RRB- cord-028721-x6f26ahr 498 1 Each each DT cord-028721-x6f26ahr 498 2 association association NN cord-028721-x6f26ahr 498 3 persists persist VBZ cord-028721-x6f26ahr 498 4 for for IN cord-028721-x6f26ahr 498 5 a a DT cord-028721-x6f26ahr 498 6 specifi specifi NN cord-028721-x6f26ahr 498 7 c c NN cord-028721-x6f26ahr 498 8 number number NN cord-028721-x6f26ahr 498 9 of of IN cord-028721-x6f26ahr 498 10 days day NNS cord-028721-x6f26ahr 498 11 ( ( -LRB- cord-028721-x6f26ahr 498 12 I -PRON- PRP cord-028721-x6f26ahr 498 13 , , , cord-028721-x6f26ahr 498 14 4.8 4.8 CD cord-028721-x6f26ahr 498 15 days day NNS cord-028721-x6f26ahr 498 16 ; ; : cord-028721-x6f26ahr 498 17 II II NNP cord-028721-x6f26ahr 498 18 , , , cord-028721-x6f26ahr 498 19 3.1 3.1 CD cord-028721-x6f26ahr 498 20 days day NNS cord-028721-x6f26ahr 498 21 ; ; : cord-028721-x6f26ahr 498 22 III III NNP cord-028721-x6f26ahr 498 23 , , , cord-028721-x6f26ahr 498 24 1 1 CD cord-028721-x6f26ahr 498 25 day day NN cord-028721-x6f26ahr 498 26 ; ; : cord-028721-x6f26ahr 498 27 IV IV NNP cord-028721-x6f26ahr 498 28 , , , cord-028721-x6f26ahr 498 29 1.2 1.2 CD cord-028721-x6f26ahr 498 30 days day NNS cord-028721-x6f26ahr 498 31 ; ; : cord-028721-x6f26ahr 498 32 V v NN cord-028721-x6f26ahr 498 33 , , , cord-028721-x6f26ahr 498 34 5 5 CD cord-028721-x6f26ahr 498 35 days day NNS cord-028721-x6f26ahr 498 36 ; ; : cord-028721-x6f26ahr 498 37 and and CC cord-028721-x6f26ahr 498 38 VI VI NNP cord-028721-x6f26ahr 498 39 , , , cord-028721-x6f26ahr 498 40 0.8 0.8 CD cord-028721-x6f26ahr 498 41 days day NNS cord-028721-x6f26ahr 498 42 ) ) -RRB- cord-028721-x6f26ahr 498 43 , , , cord-028721-x6f26ahr 498 44 and and CC cord-028721-x6f26ahr 498 45 each each DT cord-028721-x6f26ahr 498 46 successively successively RB cord-028721-x6f26ahr 498 47 transforms transform VBZ cord-028721-x6f26ahr 498 48 into into IN cord-028721-x6f26ahr 498 49 the the DT cord-028721-x6f26ahr 498 50 following follow VBG cord-028721-x6f26ahr 498 51 one one CD cord-028721-x6f26ahr 498 52 . . . cord-028721-x6f26ahr 499 1 Finally finally RB cord-028721-x6f26ahr 499 2 , , , cord-028721-x6f26ahr 499 3 at at IN cord-028721-x6f26ahr 499 4 the the DT cord-028721-x6f26ahr 499 5 end end NN cord-028721-x6f26ahr 499 6 of of IN cord-028721-x6f26ahr 499 7 association association NN cord-028721-x6f26ahr 499 8 VI VI NNP cord-028721-x6f26ahr 499 9 , , , cord-028721-x6f26ahr 499 10 the the DT cord-028721-x6f26ahr 499 11 cycle cycle NN cord-028721-x6f26ahr 499 12 is be VBZ cord-028721-x6f26ahr 499 13 repeated repeat VBN cord-028721-x6f26ahr 499 14 ; ; : cord-028721-x6f26ahr 499 15 the the DT cord-028721-x6f26ahr 499 16 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 499 17 process process NN cord-028721-x6f26ahr 499 18 requires require VBZ cord-028721-x6f26ahr 499 19 4.6 4.6 CD cord-028721-x6f26ahr 499 20 cycles cycle NNS cord-028721-x6f26ahr 499 21 . . . cord-028721-x6f26ahr 500 1 168 168 CD cord-028721-x6f26ahr 501 1 Because because IN cord-028721-x6f26ahr 501 2 each each DT cord-028721-x6f26ahr 501 3 cycle cycle NN cord-028721-x6f26ahr 501 4 lasts last VBZ cord-028721-x6f26ahr 501 5 15.9 15.9 CD cord-028721-x6f26ahr 501 6 days day NNS cord-028721-x6f26ahr 501 7 , , , cord-028721-x6f26ahr 501 8 the the DT cord-028721-x6f26ahr 501 9 transformation transformation NN cord-028721-x6f26ahr 501 10 of of IN cord-028721-x6f26ahr 501 11 spermatogonium spermatogonium NN cord-028721-x6f26ahr 501 12 into into IN cord-028721-x6f26ahr 501 13 spermatozoon spermatozoon NN cord-028721-x6f26ahr 501 14 takes take VBZ cord-028721-x6f26ahr 501 15 74 74 CD cord-028721-x6f26ahr 501 16 days day NNS cord-028721-x6f26ahr 501 17 ( ( -LRB- cord-028721-x6f26ahr 501 18 Fig Fig NNP cord-028721-x6f26ahr 501 19 . . . cord-028721-x6f26ahr 501 20 12 12 CD cord-028721-x6f26ahr 501 21 - - SYM cord-028721-x6f26ahr 501 22 22 22 CD cord-028721-x6f26ahr 501 23 ) ) -RRB- cord-028721-x6f26ahr 501 24 . . . cord-028721-x6f26ahr 502 1 The the DT cord-028721-x6f26ahr 502 2 succession succession NN cord-028721-x6f26ahr 502 3 of of IN cord-028721-x6f26ahr 502 4 different different JJ cord-028721-x6f26ahr 502 5 associations association NNS cord-028721-x6f26ahr 502 6 probably probably RB cord-028721-x6f26ahr 502 7 depends depend VBZ cord-028721-x6f26ahr 502 8 on on IN cord-028721-x6f26ahr 502 9 cyclic cyclic JJ cord-028721-x6f26ahr 502 10 Sertoli sertoli JJ cord-028721-x6f26ahr 502 11 cell cell NN cord-028721-x6f26ahr 502 12 activity activity NN cord-028721-x6f26ahr 502 13 . . . cord-028721-x6f26ahr 503 1 Cyclic cyclic JJ cord-028721-x6f26ahr 503 2 changes change NNS cord-028721-x6f26ahr 503 3 in in IN cord-028721-x6f26ahr 503 4 the the DT cord-028721-x6f26ahr 503 5 mitochondria mitochondrion NNS cord-028721-x6f26ahr 503 6 , , , cord-028721-x6f26ahr 503 7 rough rough JJ cord-028721-x6f26ahr 503 8 endoplasmic endoplasmic NN cord-028721-x6f26ahr 503 9 reticulum reticulum NN cord-028721-x6f26ahr 503 10 , , , cord-028721-x6f26ahr 503 11 Golgi Golgi NNP cord-028721-x6f26ahr 503 12 complex complex NN cord-028721-x6f26ahr 503 13 , , , cord-028721-x6f26ahr 503 14 lysosomes lysosome NNS cord-028721-x6f26ahr 503 15 , , , cord-028721-x6f26ahr 503 16 and and CC cord-028721-x6f26ahr 503 17 lipid lipid NN cord-028721-x6f26ahr 503 18 droplets droplet NNS cord-028721-x6f26ahr 503 19 have have VBP cord-028721-x6f26ahr 503 20 been be VBN cord-028721-x6f26ahr 503 21 reported report VBN cord-028721-x6f26ahr 503 22 . . . cord-028721-x6f26ahr 504 1 [ [ -LRB- cord-028721-x6f26ahr 504 2 169 169 CD cord-028721-x6f26ahr 504 3 ] ] -RRB- cord-028721-x6f26ahr 504 4 [ [ -LRB- cord-028721-x6f26ahr 504 5 170 170 CD cord-028721-x6f26ahr 504 6 ] ] -RRB- cord-028721-x6f26ahr 504 7 [ [ -LRB- cord-028721-x6f26ahr 504 8 171 171 CD cord-028721-x6f26ahr 504 9 ] ] -RRB- cord-028721-x6f26ahr 505 1 This this DT cord-028721-x6f26ahr 505 2 cyclic cyclic JJ cord-028721-x6f26ahr 505 3 activity activity NN cord-028721-x6f26ahr 505 4 is be VBZ cord-028721-x6f26ahr 505 5 probably probably RB cord-028721-x6f26ahr 505 6 regulated regulate VBN cord-028721-x6f26ahr 505 7 by by IN cord-028721-x6f26ahr 505 8 germ germ NN cord-028721-x6f26ahr 505 9 cell cell NN cord-028721-x6f26ahr 505 10 signals signal NNS cord-028721-x6f26ahr 505 11 . . . cord-028721-x6f26ahr 506 1 172 172 CD cord-028721-x6f26ahr 507 1 The the DT cord-028721-x6f26ahr 507 2 yield yield NN cord-028721-x6f26ahr 507 3 of of IN cord-028721-x6f26ahr 507 4 human human JJ cord-028721-x6f26ahr 507 5 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 507 6 is be VBZ cord-028721-x6f26ahr 507 7 lower low JJR cord-028721-x6f26ahr 507 8 than than IN cord-028721-x6f26ahr 507 9 that that DT cord-028721-x6f26ahr 507 10 of of IN cord-028721-x6f26ahr 507 11 Embryology embryology NN cord-028721-x6f26ahr 507 12 and and CC cord-028721-x6f26ahr 507 13 anatomy anatomy NN cord-028721-x6f26ahr 507 14 of of IN cord-028721-x6f26ahr 507 15 the the DT cord-028721-x6f26ahr 507 16 testis testis NN cord-028721-x6f26ahr 507 17 _SP cord-028721-x6f26ahr 508 1 The the DT cord-028721-x6f26ahr 508 2 six six CD cord-028721-x6f26ahr 508 3 different different JJ cord-028721-x6f26ahr 508 4 germ germ NN cord-028721-x6f26ahr 508 5 cell cell NN cord-028721-x6f26ahr 508 6 associations association NNS cord-028721-x6f26ahr 508 7 of of IN cord-028721-x6f26ahr 508 8 the the DT cord-028721-x6f26ahr 508 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 508 10 tubules tubule NNS cord-028721-x6f26ahr 508 11 and and CC cord-028721-x6f26ahr 508 12 the the DT cord-028721-x6f26ahr 508 13 sequence sequence NN cord-028721-x6f26ahr 508 14 of of IN cord-028721-x6f26ahr 508 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 508 16 . . . cord-028721-x6f26ahr 509 1 Completion completion NN cord-028721-x6f26ahr 509 2 of of IN cord-028721-x6f26ahr 509 3 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 509 4 requires require VBZ cord-028721-x6f26ahr 509 5 more more JJR cord-028721-x6f26ahr 509 6 than than IN cord-028721-x6f26ahr 509 7 four four CD cord-028721-x6f26ahr 509 8 cycles cycle NNS cord-028721-x6f26ahr 509 9 and and CC cord-028721-x6f26ahr 509 10 lasts last VBZ cord-028721-x6f26ahr 509 11 for for IN cord-028721-x6f26ahr 509 12 approximately approximately RB cord-028721-x6f26ahr 509 13 74 74 CD cord-028721-x6f26ahr 509 14 days day NNS cord-028721-x6f26ahr 509 15 . . . cord-028721-x6f26ahr 510 1 Each each DT cord-028721-x6f26ahr 510 2 association association NN cord-028721-x6f26ahr 510 3 is be VBZ cord-028721-x6f26ahr 510 4 indicated indicate VBN cord-028721-x6f26ahr 510 5 by by IN cord-028721-x6f26ahr 510 6 Roman roman JJ cord-028721-x6f26ahr 510 7 numerals numeral NNS cord-028721-x6f26ahr 510 8 with with IN cord-028721-x6f26ahr 510 9 its -PRON- PRP$ cord-028721-x6f26ahr 510 10 corresponding corresponding JJ cord-028721-x6f26ahr 510 11 duration duration NN cord-028721-x6f26ahr 510 12 . . . cord-028721-x6f26ahr 511 1 Ad ad NN cord-028721-x6f26ahr 511 2 : : : cord-028721-x6f26ahr 511 3 dark dark JJ cord-028721-x6f26ahr 511 4 type type NN cord-028721-x6f26ahr 511 5 of of IN cord-028721-x6f26ahr 511 6 A a DT cord-028721-x6f26ahr 511 7 spermatogonia spermatogonia NN cord-028721-x6f26ahr 511 8 ; ; : cord-028721-x6f26ahr 511 9 Ap ap NN cord-028721-x6f26ahr 511 10 : : : cord-028721-x6f26ahr 511 11 pale pale JJ cord-028721-x6f26ahr 511 12 type type NN cord-028721-x6f26ahr 511 13 of of IN cord-028721-x6f26ahr 511 14 a a DT cord-028721-x6f26ahr 511 15 spermatogonia spermatogonia NN cord-028721-x6f26ahr 511 16 ; ; : cord-028721-x6f26ahr 511 17 B b NN cord-028721-x6f26ahr 511 18 : : : cord-028721-x6f26ahr 511 19 B B NNP cord-028721-x6f26ahr 511 20 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 511 21 ; ; : cord-028721-x6f26ahr 511 22 I -PRON- PRP cord-028721-x6f26ahr 511 23 : : : cord-028721-x6f26ahr 511 24 interphase interphase NN cord-028721-x6f26ahr 511 25 primary primary JJ cord-028721-x6f26ahr 511 26 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 511 27 ; ; : cord-028721-x6f26ahr 511 28 L l NN cord-028721-x6f26ahr 511 29 : : : cord-028721-x6f26ahr 511 30 leptotene leptotene NNP cord-028721-x6f26ahr 511 31 primary primary JJ cord-028721-x6f26ahr 511 32 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 511 33 ; ; : cord-028721-x6f26ahr 511 34 Z z NN cord-028721-x6f26ahr 511 35 : : : cord-028721-x6f26ahr 511 36 zygotene zygotene NNP cord-028721-x6f26ahr 511 37 primary primary JJ cord-028721-x6f26ahr 511 38 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 511 39 ; ; : cord-028721-x6f26ahr 511 40 P p NN cord-028721-x6f26ahr 511 41 : : : cord-028721-x6f26ahr 511 42 pachytene pachytene NNP cord-028721-x6f26ahr 511 43 primary primary JJ cord-028721-x6f26ahr 511 44 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 511 45 ; ; : cord-028721-x6f26ahr 511 46 II II NNP cord-028721-x6f26ahr 511 47 : : : cord-028721-x6f26ahr 511 48 secondary secondary JJ cord-028721-x6f26ahr 511 49 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 511 50 ( ( -LRB- cord-028721-x6f26ahr 511 51 only only RB cord-028721-x6f26ahr 511 52 in in IN cord-028721-x6f26ahr 511 53 stage stage NN cord-028721-x6f26ahr 511 54 VI VI NNP cord-028721-x6f26ahr 511 55 ) ) -RRB- cord-028721-x6f26ahr 511 56 . . . cord-028721-x6f26ahr 512 1 S S NNP cord-028721-x6f26ahr 512 2 a a NNP cord-028721-x6f26ahr 512 3 , , , cord-028721-x6f26ahr 512 4 S S NNP cord-028721-x6f26ahr 512 5 b1 b1 NN cord-028721-x6f26ahr 512 6 , , , cord-028721-x6f26ahr 512 7 S S NNP cord-028721-x6f26ahr 512 8 b2 b2 NN cord-028721-x6f26ahr 512 9 , , , cord-028721-x6f26ahr 512 10 S S NNP cord-028721-x6f26ahr 512 11 c c NN cord-028721-x6f26ahr 512 12 , , , cord-028721-x6f26ahr 512 13 S S NNP cord-028721-x6f26ahr 512 14 d1 d1 NN cord-028721-x6f26ahr 512 15 , , , cord-028721-x6f26ahr 512 16 and and CC cord-028721-x6f26ahr 512 17 S S NNP cord-028721-x6f26ahr 512 18 d2 d2 NNP cord-028721-x6f26ahr 512 19 represent represent VBP cord-028721-x6f26ahr 512 20 the the DT cord-028721-x6f26ahr 512 21 progressive progressive JJ cord-028721-x6f26ahr 512 22 stages stage NNS cord-028721-x6f26ahr 512 23 of of IN cord-028721-x6f26ahr 512 24 spermatid spermatid JJ cord-028721-x6f26ahr 512 25 differentiation differentiation NN cord-028721-x6f26ahr 512 26 into into IN cord-028721-x6f26ahr 512 27 spermatozoa spermatozoa NN cord-028721-x6f26ahr 512 28 . . . cord-028721-x6f26ahr 513 1 most most JJS cord-028721-x6f26ahr 513 2 mammalian mammalian JJ cord-028721-x6f26ahr 513 3 species specie NNS cord-028721-x6f26ahr 513 4 , , , cord-028721-x6f26ahr 513 5 including include VBG cord-028721-x6f26ahr 513 6 primates primate NNS cord-028721-x6f26ahr 513 7 , , , cord-028721-x6f26ahr 513 8 with with IN cord-028721-x6f26ahr 513 9 maximal maximal JJ cord-028721-x6f26ahr 513 10 cell cell NN cord-028721-x6f26ahr 513 11 degeneration degeneration NN cord-028721-x6f26ahr 513 12 occurring occur VBG cord-028721-x6f26ahr 513 13 at at IN cord-028721-x6f26ahr 513 14 the the DT cord-028721-x6f26ahr 513 15 end end NN cord-028721-x6f26ahr 513 16 of of IN cord-028721-x6f26ahr 513 17 meiosis meiosis NN cord-028721-x6f26ahr 513 18 . . . cord-028721-x6f26ahr 514 1 173 173 CD cord-028721-x6f26ahr 514 2 _SP cord-028721-x6f26ahr 515 1 The the DT cord-028721-x6f26ahr 515 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 515 3 tubule tubule NN cord-028721-x6f26ahr 515 4 is be VBZ cord-028721-x6f26ahr 515 5 surrounded surround VBN cord-028721-x6f26ahr 515 6 by by IN cord-028721-x6f26ahr 515 7 a a DT cord-028721-x6f26ahr 515 8 6 6 CD cord-028721-x6f26ahr 515 9 µm µm NN cord-028721-x6f26ahr 515 10 thick thick JJ cord-028721-x6f26ahr 515 11 lamina lamina JJ cord-028721-x6f26ahr 515 12 propria propria FW cord-028721-x6f26ahr 515 13 ( ( -LRB- cord-028721-x6f26ahr 515 14 tunica tunica NNP cord-028721-x6f26ahr 515 15 propria propria NNP cord-028721-x6f26ahr 515 16 ) ) -RRB- cord-028721-x6f26ahr 515 17 consisting consist VBG cord-028721-x6f26ahr 515 18 of of IN cord-028721-x6f26ahr 515 19 a a DT cord-028721-x6f26ahr 515 20 basement basement NN cord-028721-x6f26ahr 515 21 membrane membrane NN cord-028721-x6f26ahr 515 22 , , , cord-028721-x6f26ahr 515 23 myofi myofi NNP cord-028721-x6f26ahr 515 24 broblasts broblasts NNP cord-028721-x6f26ahr 515 25 , , , cord-028721-x6f26ahr 515 26 fi fi NNP cord-028721-x6f26ahr 515 27 broblasts broblasts NNP cord-028721-x6f26ahr 515 28 , , , cord-028721-x6f26ahr 515 29 collagen collagen NN cord-028721-x6f26ahr 515 30 and and CC cord-028721-x6f26ahr 515 31 elastic elastic JJ cord-028721-x6f26ahr 515 32 fi fi NN cord-028721-x6f26ahr 515 33 bers ber NNS cord-028721-x6f26ahr 515 34 , , , cord-028721-x6f26ahr 515 35 and and CC cord-028721-x6f26ahr 515 36 extracellular extracellular JJ cord-028721-x6f26ahr 515 37 matrix matrix NN cord-028721-x6f26ahr 515 38 . . . cord-028721-x6f26ahr 516 1 174 174 CD cord-028721-x6f26ahr 516 2 , , , cord-028721-x6f26ahr 516 3 175 175 CD cord-028721-x6f26ahr 517 1 The the DT cord-028721-x6f26ahr 517 2 basement basement NN cord-028721-x6f26ahr 517 3 membrane membrane NN cord-028721-x6f26ahr 517 4 measures measure VBZ cord-028721-x6f26ahr 517 5 100 100 CD cord-028721-x6f26ahr 517 6 - - SYM cord-028721-x6f26ahr 517 7 200 200 CD cord-028721-x6f26ahr 517 8 nm nm NN cord-028721-x6f26ahr 517 9 in in IN cord-028721-x6f26ahr 517 10 thickness thickness NN cord-028721-x6f26ahr 517 11 , , , cord-028721-x6f26ahr 517 12 and and CC cord-028721-x6f26ahr 517 13 displays display VBZ cord-028721-x6f26ahr 517 14 three three CD cord-028721-x6f26ahr 517 15 layers layer NNS cord-028721-x6f26ahr 517 16 : : : cord-028721-x6f26ahr 517 17 lamina lamina NNP cord-028721-x6f26ahr 517 18 lucida lucida NNP cord-028721-x6f26ahr 517 19 ( ( -LRB- cord-028721-x6f26ahr 517 20 beneath beneath IN cord-028721-x6f26ahr 517 21 the the DT cord-028721-x6f26ahr 517 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 517 23 cells cell NNS cord-028721-x6f26ahr 517 24 ) ) -RRB- cord-028721-x6f26ahr 517 25 , , , cord-028721-x6f26ahr 517 26 lamina lamina NNP cord-028721-x6f26ahr 517 27 densa densa NNP cord-028721-x6f26ahr 517 28 ( ( -LRB- cord-028721-x6f26ahr 517 29 basal basal NNP cord-028721-x6f26ahr 517 30 lamina lamina NNP cord-028721-x6f26ahr 517 31 ) ) -RRB- cord-028721-x6f26ahr 517 32 , , , cord-028721-x6f26ahr 517 33 and and CC cord-028721-x6f26ahr 517 34 lamina lamina NNP cord-028721-x6f26ahr 517 35 reticularis reticularis NNPS cord-028721-x6f26ahr 517 36 ( ( -LRB- cord-028721-x6f26ahr 517 37 a a DT cord-028721-x6f26ahr 517 38 discontinuous discontinuous JJ cord-028721-x6f26ahr 517 39 layer layer NN cord-028721-x6f26ahr 517 40 containing contain VBG cord-028721-x6f26ahr 517 41 fi fi NNP cord-028721-x6f26ahr 517 42 bers ber NNS cord-028721-x6f26ahr 517 43 ) ) -RRB- cord-028721-x6f26ahr 517 44 . . . cord-028721-x6f26ahr 518 1 The the DT cord-028721-x6f26ahr 518 2 basal basal NN cord-028721-x6f26ahr 518 3 lamina lamina NN cord-028721-x6f26ahr 518 4 contains contain VBZ cord-028721-x6f26ahr 518 5 laminin laminin NN cord-028721-x6f26ahr 518 6 , , , cord-028721-x6f26ahr 518 7 type type NN cord-028721-x6f26ahr 518 8 IV IV NNP cord-028721-x6f26ahr 518 9 collagen collagen NN cord-028721-x6f26ahr 518 10 , , , cord-028721-x6f26ahr 518 11 entactin entactin NNP cord-028721-x6f26ahr 518 12 ( ( -LRB- cord-028721-x6f26ahr 518 13 nidogen nidogen NNP cord-028721-x6f26ahr 518 14 ) ) -RRB- cord-028721-x6f26ahr 518 15 , , , cord-028721-x6f26ahr 518 16 and and CC cord-028721-x6f26ahr 518 17 heparan heparan NN cord-028721-x6f26ahr 518 18 sulfate sulfate NN cord-028721-x6f26ahr 518 19 . . . cord-028721-x6f26ahr 519 1 176 176 CD cord-028721-x6f26ahr 519 2 External External NNP cord-028721-x6f26ahr 519 3 to to IN cord-028721-x6f26ahr 519 4 the the DT cord-028721-x6f26ahr 519 5 basal basal NN cord-028721-x6f26ahr 519 6 lamina lamina NN cord-028721-x6f26ahr 519 7 there there EX cord-028721-x6f26ahr 519 8 are be VBP cord-028721-x6f26ahr 519 9 fi fi NNP cord-028721-x6f26ahr 519 10 ve ve VBD cord-028721-x6f26ahr 519 11 to to IN cord-028721-x6f26ahr 519 12 seven seven CD cord-028721-x6f26ahr 519 13 layers layer NNS cord-028721-x6f26ahr 519 14 of of IN cord-028721-x6f26ahr 519 15 fl fl NNP cord-028721-x6f26ahr 520 1 attened attene VBN cord-028721-x6f26ahr 520 2 , , , cord-028721-x6f26ahr 520 3 elongated elongated JJ cord-028721-x6f26ahr 520 4 peritubular peritubular JJ cord-028721-x6f26ahr 520 5 cells cell NNS cord-028721-x6f26ahr 520 6 that that WDT cord-028721-x6f26ahr 520 7 have have VBP cord-028721-x6f26ahr 520 8 important important JJ cord-028721-x6f26ahr 520 9 secretory secretory JJ cord-028721-x6f26ahr 520 10 functions function NNS cord-028721-x6f26ahr 520 11 ( ( -LRB- cord-028721-x6f26ahr 520 12 Table Table NNP cord-028721-x6f26ahr 520 13 12 12 CD cord-028721-x6f26ahr 520 14 - - SYM cord-028721-x6f26ahr 520 15 3 3 CD cord-028721-x6f26ahr 520 16 ) ) -RRB- cord-028721-x6f26ahr 520 17 . . . cord-028721-x6f26ahr 521 1 177 177 CD cord-028721-x6f26ahr 522 1 The the DT cord-028721-x6f26ahr 522 2 cells cell NNS cord-028721-x6f26ahr 522 3 forming form VBG cord-028721-x6f26ahr 522 4 the the DT cord-028721-x6f26ahr 522 5 three three CD cord-028721-x6f26ahr 522 6 to to TO cord-028721-x6f26ahr 522 7 fi fi VB cord-028721-x6f26ahr 522 8 ve ve VBD cord-028721-x6f26ahr 522 9 innermost innermost JJ cord-028721-x6f26ahr 522 10 layers layer NNS cord-028721-x6f26ahr 522 11 are be VBP cord-028721-x6f26ahr 522 12 myofi myofi NNP cord-028721-x6f26ahr 522 13 broblasts broblasts NNP cord-028721-x6f26ahr 522 14 containing contain VBG cord-028721-x6f26ahr 522 15 numerous numerous JJ cord-028721-x6f26ahr 522 16 actin actin NN cord-028721-x6f26ahr 522 17 , , , cord-028721-x6f26ahr 522 18 myosin myosin NNS cord-028721-x6f26ahr 522 19 , , , cord-028721-x6f26ahr 522 20 and and CC cord-028721-x6f26ahr 522 21 desmin desmin NNP cord-028721-x6f26ahr 522 22 fi fi NNP cord-028721-x6f26ahr 522 23 laments lament NNS cord-028721-x6f26ahr 522 24 . . . cord-028721-x6f26ahr 523 1 These these DT cord-028721-x6f26ahr 523 2 cells cell NNS cord-028721-x6f26ahr 523 3 play play VBP cord-028721-x6f26ahr 523 4 an an DT cord-028721-x6f26ahr 523 5 important important JJ cord-028721-x6f26ahr 523 6 role role NN cord-028721-x6f26ahr 523 7 in in IN cord-028721-x6f26ahr 523 8 the the DT cord-028721-x6f26ahr 523 9 rhythmic rhythmic JJ cord-028721-x6f26ahr 523 10 tubular tubular JJ cord-028721-x6f26ahr 523 11 contractions contraction NNS cord-028721-x6f26ahr 523 12 that that WDT cord-028721-x6f26ahr 523 13 propel propel VBP cord-028721-x6f26ahr 523 14 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 523 15 toward toward IN cord-028721-x6f26ahr 523 16 the the DT cord-028721-x6f26ahr 523 17 rete rete NN cord-028721-x6f26ahr 523 18 testis testis NN cord-028721-x6f26ahr 523 19 . . . cord-028721-x6f26ahr 524 1 178 178 CD cord-028721-x6f26ahr 524 2 , , , cord-028721-x6f26ahr 524 3 179 179 CD cord-028721-x6f26ahr 525 1 The the DT cord-028721-x6f26ahr 525 2 two two CD cord-028721-x6f26ahr 525 3 outermost outermost JJ cord-028721-x6f26ahr 525 4 cell cell NN cord-028721-x6f26ahr 525 5 layers layer NNS cord-028721-x6f26ahr 525 6 consist consist VBP cord-028721-x6f26ahr 525 7 of of IN cord-028721-x6f26ahr 525 8 fi fi NNP cord-028721-x6f26ahr 525 9 broblasts broblasts NNP cord-028721-x6f26ahr 525 10 without without IN cord-028721-x6f26ahr 525 11 desmin desmin NNP cord-028721-x6f26ahr 525 12 fi fi NNP cord-028721-x6f26ahr 525 13 laments lament VBZ cord-028721-x6f26ahr 525 14 , , , cord-028721-x6f26ahr 525 15 and and CC cord-028721-x6f26ahr 525 16 with with IN cord-028721-x6f26ahr 525 17 less less JJR cord-028721-x6f26ahr 525 18 actin actin NN cord-028721-x6f26ahr 525 19 and and CC cord-028721-x6f26ahr 525 20 myosin myosin NNS cord-028721-x6f26ahr 525 21 than than IN cord-028721-x6f26ahr 525 22 the the DT cord-028721-x6f26ahr 525 23 myofi myofi NNP cord-028721-x6f26ahr 525 24 broblasts broblasts NNP cord-028721-x6f26ahr 525 25 . . . cord-028721-x6f26ahr 526 1 Collagen collagen NN cord-028721-x6f26ahr 526 2 fi fi NN cord-028721-x6f26ahr 526 3 bers ber NNS cord-028721-x6f26ahr 526 4 are be VBP cord-028721-x6f26ahr 526 5 present present JJ cord-028721-x6f26ahr 526 6 among among IN cord-028721-x6f26ahr 526 7 the the DT cord-028721-x6f26ahr 526 8 peritubular peritubular JJ cord-028721-x6f26ahr 526 9 cells cell NNS cord-028721-x6f26ahr 526 10 and and CC cord-028721-x6f26ahr 526 11 are be VBP cord-028721-x6f26ahr 526 12 abundant abundant JJ cord-028721-x6f26ahr 526 13 between between IN cord-028721-x6f26ahr 526 14 the the DT cord-028721-x6f26ahr 526 15 basal basal NN cord-028721-x6f26ahr 526 16 lamina lamina NN cord-028721-x6f26ahr 526 17 and and CC cord-028721-x6f26ahr 526 18 the the DT cord-028721-x6f26ahr 526 19 peritubular peritubular NNP cord-028721-x6f26ahr 526 20 cells cell NNS cord-028721-x6f26ahr 526 21 . . . cord-028721-x6f26ahr 527 1 Elastic elastic JJ cord-028721-x6f26ahr 527 2 fi fi NN cord-028721-x6f26ahr 527 3 bers ber NNS cord-028721-x6f26ahr 527 4 are be VBP cord-028721-x6f26ahr 527 5 located locate VBN cord-028721-x6f26ahr 527 6 mainly mainly RB cord-028721-x6f26ahr 527 7 at at IN cord-028721-x6f26ahr 527 8 the the DT cord-028721-x6f26ahr 527 9 periphery periphery NN cord-028721-x6f26ahr 527 10 of of IN cord-028721-x6f26ahr 527 11 peritubular peritubular JJ cord-028721-x6f26ahr 527 12 cells cell NNS cord-028721-x6f26ahr 527 13 . . . cord-028721-x6f26ahr 528 1 Because because IN cord-028721-x6f26ahr 528 2 elastic elastic JJ cord-028721-x6f26ahr 528 3 fi fi NN cord-028721-x6f26ahr 528 4 bers ber NNS cord-028721-x6f26ahr 528 5 appear appear VBP cord-028721-x6f26ahr 528 6 at at IN cord-028721-x6f26ahr 528 7 puberty puberty NN cord-028721-x6f26ahr 528 8 , , , cord-028721-x6f26ahr 528 9 their -PRON- PRP$ cord-028721-x6f26ahr 528 10 absence absence NN cord-028721-x6f26ahr 528 11 in in IN cord-028721-x6f26ahr 528 12 adults adult NNS cord-028721-x6f26ahr 528 13 is be VBZ cord-028721-x6f26ahr 528 14 a a DT cord-028721-x6f26ahr 528 15 sign sign NN cord-028721-x6f26ahr 528 16 of of IN cord-028721-x6f26ahr 528 17 tubular tubular JJ cord-028721-x6f26ahr 528 18 immaturity immaturity NN cord-028721-x6f26ahr 528 19 or or CC cord-028721-x6f26ahr 528 20 dysgenesis dysgenesis NN cord-028721-x6f26ahr 528 21 . . . cord-028721-x6f26ahr 529 1 180 180 CD cord-028721-x6f26ahr 530 1 The the DT cord-028721-x6f26ahr 530 2 extracellular extracellular JJ cord-028721-x6f26ahr 530 3 matrix matrix NN cord-028721-x6f26ahr 530 4 contains contain VBZ cord-028721-x6f26ahr 530 5 proteoglycans proteoglycan NNS cord-028721-x6f26ahr 530 6 and and CC cord-028721-x6f26ahr 530 7 fi fi NNP cord-028721-x6f26ahr 530 8 bronectin bronectin NNP cord-028721-x6f26ahr 530 9 . . . cord-028721-x6f26ahr 531 1 In in IN cord-028721-x6f26ahr 531 2 addition addition NN cord-028721-x6f26ahr 531 3 , , , cord-028721-x6f26ahr 531 4 the the DT cord-028721-x6f26ahr 531 5 tubular tubular JJ cord-028721-x6f26ahr 531 6 wall wall NN cord-028721-x6f26ahr 531 7 contains contain VBZ cord-028721-x6f26ahr 531 8 capillaries capillary NNS cord-028721-x6f26ahr 531 9 and and CC cord-028721-x6f26ahr 531 10 Leydig leydig NN cord-028721-x6f26ahr 531 11 cells cell NNS cord-028721-x6f26ahr 531 12 . . . cord-028721-x6f26ahr 532 1 These these DT cord-028721-x6f26ahr 532 2 are be VBP cord-028721-x6f26ahr 532 3 very very RB cord-028721-x6f26ahr 532 4 similar similar JJ cord-028721-x6f26ahr 532 5 to to IN cord-028721-x6f26ahr 532 6 the the DT cord-028721-x6f26ahr 532 7 interstitial interstitial JJ cord-028721-x6f26ahr 532 8 Leydig Leydig NNP cord-028721-x6f26ahr 532 9 cells cell NNS cord-028721-x6f26ahr 532 10 and and CC cord-028721-x6f26ahr 532 11 are be VBP cord-028721-x6f26ahr 532 12 named name VBN cord-028721-x6f26ahr 532 13 peritubular peritubular NNP cord-028721-x6f26ahr 532 14 Leydig Leydig NNP cord-028721-x6f26ahr 532 15 cells cell NNS cord-028721-x6f26ahr 532 16 . . . cord-028721-x6f26ahr 533 1 The the DT cord-028721-x6f26ahr 533 2 most most RBS cord-028721-x6f26ahr 533 3 important important JJ cord-028721-x6f26ahr 533 4 functions function NNS cord-028721-x6f26ahr 533 5 of of IN cord-028721-x6f26ahr 533 6 myofi myofi NNP cord-028721-x6f26ahr 533 7 broblasts broblasts NNP cord-028721-x6f26ahr 533 8 are be VBP cord-028721-x6f26ahr 533 9 contraction contraction NN cord-028721-x6f26ahr 533 10 of of IN cord-028721-x6f26ahr 533 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 533 12 tubules tubule NNS cord-028721-x6f26ahr 533 13 and and CC cord-028721-x6f26ahr 533 14 control control NN cord-028721-x6f26ahr 533 15 of of IN cord-028721-x6f26ahr 533 16 Sertoli Sertoli NNP cord-028721-x6f26ahr 533 17 cells cell NNS cord-028721-x6f26ahr 533 18 . . . cord-028721-x6f26ahr 534 1 181 181 CD cord-028721-x6f26ahr 535 1 Myofi Myofi NNP cord-028721-x6f26ahr 535 2 broblasts broblast NNS cord-028721-x6f26ahr 535 3 have have VBP cord-028721-x6f26ahr 535 4 α α NN cord-028721-x6f26ahr 535 5 and and CC cord-028721-x6f26ahr 535 6 β β NN cord-028721-x6f26ahr 535 7 adrenergic adrenergic JJ cord-028721-x6f26ahr 535 8 and and CC cord-028721-x6f26ahr 535 9 muscarinic muscarinic JJ cord-028721-x6f26ahr 535 10 receptors receptor NNS cord-028721-x6f26ahr 535 11 . . . cord-028721-x6f26ahr 536 1 182 182 CD cord-028721-x6f26ahr 537 1 Contractility Contractility NNP cord-028721-x6f26ahr 537 2 depends depend VBZ cord-028721-x6f26ahr 537 3 on on IN cord-028721-x6f26ahr 537 4 several several JJ cord-028721-x6f26ahr 537 5 factors factor NNS cord-028721-x6f26ahr 537 6 produced produce VBN cord-028721-x6f26ahr 537 7 in in IN cord-028721-x6f26ahr 537 8 the the DT cord-028721-x6f26ahr 537 9 testis testis NN cord-028721-x6f26ahr 537 10 ( ( -LRB- cord-028721-x6f26ahr 537 11 endothelin-1 endothelin-1 NNP cord-028721-x6f26ahr 537 12 , , , cord-028721-x6f26ahr 537 13 vasopressin vasopressin NN cord-028721-x6f26ahr 537 14 , , , cord-028721-x6f26ahr 537 15 oxytocin oxytocin NN cord-028721-x6f26ahr 537 16 , , , cord-028721-x6f26ahr 537 17 and and CC cord-028721-x6f26ahr 537 18 TGF TGF NNP cord-028721-x6f26ahr 537 19 - - HYPH cord-028721-x6f26ahr 537 20 β β NNP cord-028721-x6f26ahr 537 21 ) ) -RRB- cord-028721-x6f26ahr 537 22 and and CC cord-028721-x6f26ahr 537 23 prostaglandins prostaglandin NNS cord-028721-x6f26ahr 537 24 . . . cord-028721-x6f26ahr 538 1 Relaxation relaxation NN cord-028721-x6f26ahr 538 2 can can MD cord-028721-x6f26ahr 538 3 be be VB cord-028721-x6f26ahr 538 4 facilitated facilitate VBN cord-028721-x6f26ahr 538 5 by by IN cord-028721-x6f26ahr 538 6 the the DT cord-028721-x6f26ahr 538 7 NO NO NNP cord-028721-x6f26ahr 538 8 / / SYM cord-028721-x6f26ahr 538 9 cGMP cGMP NNP cord-028721-x6f26ahr 538 10 system system NN cord-028721-x6f26ahr 538 11 because because IN cord-028721-x6f26ahr 538 12 myofi myofi NNP cord-028721-x6f26ahr 538 13 broblasts broblasts NNP cord-028721-x6f26ahr 538 14 are be VBP cord-028721-x6f26ahr 538 15 also also RB cord-028721-x6f26ahr 538 16 able able JJ cord-028721-x6f26ahr 538 17 to to TO cord-028721-x6f26ahr 538 18 synthesize synthesize VB cord-028721-x6f26ahr 538 19 nitric nitric NN cord-028721-x6f26ahr 538 20 oxide oxide NN cord-028721-x6f26ahr 538 21 . . . cord-028721-x6f26ahr 539 1 Sertoli sertoli JJ cord-028721-x6f26ahr 539 2 cell cell NN cord-028721-x6f26ahr 539 3 control control NN cord-028721-x6f26ahr 539 4 by by IN cord-028721-x6f26ahr 539 5 myofibroblasts myofibroblast NNS cord-028721-x6f26ahr 539 6 is be VBZ cord-028721-x6f26ahr 539 7 facilitated facilitate VBN cord-028721-x6f26ahr 539 8 by by IN cord-028721-x6f26ahr 539 9 the the DT cord-028721-x6f26ahr 539 10 production production NN cord-028721-x6f26ahr 539 11 of of IN cord-028721-x6f26ahr 539 12 P p NN cord-028721-x6f26ahr 539 13 - - HYPH cord-028721-x6f26ahr 539 14 Mod Mod NNP cord-028721-x6f26ahr 539 15 - - HYPH cord-028721-x6f26ahr 539 16 S S NNP cord-028721-x6f26ahr 539 17 , , , cord-028721-x6f26ahr 539 18 which which WDT cord-028721-x6f26ahr 539 19 activates activate VBZ cord-028721-x6f26ahr 539 20 aromatase aromatase NN cord-028721-x6f26ahr 539 21 activity activity NN cord-028721-x6f26ahr 539 22 , , , cord-028721-x6f26ahr 539 23 inhibin inhibin NN cord-028721-x6f26ahr 539 24 production production NN cord-028721-x6f26ahr 539 25 , , , cord-028721-x6f26ahr 539 26 and and CC cord-028721-x6f26ahr 539 27 the the DT cord-028721-x6f26ahr 539 28 secretion secretion NN cord-028721-x6f26ahr 539 29 of of IN cord-028721-x6f26ahr 539 30 androgen androgen NN cord-028721-x6f26ahr 539 31 - - HYPH cord-028721-x6f26ahr 539 32 binding bind VBG cord-028721-x6f26ahr 539 33 protein protein NN cord-028721-x6f26ahr 539 34 and and CC cord-028721-x6f26ahr 539 35 transferrin transferrin NN cord-028721-x6f26ahr 539 36 . . . cord-028721-x6f26ahr 540 1 The the DT cord-028721-x6f26ahr 540 2 interstitium interstitium NN cord-028721-x6f26ahr 540 3 between between IN cord-028721-x6f26ahr 540 4 the the DT cord-028721-x6f26ahr 540 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 540 6 tubules tubule NNS cord-028721-x6f26ahr 540 7 contain contain VBP cord-028721-x6f26ahr 540 8 Leydig leydig NN cord-028721-x6f26ahr 540 9 cells cell NNS cord-028721-x6f26ahr 540 10 , , , cord-028721-x6f26ahr 540 11 macrophages macrophage NNS cord-028721-x6f26ahr 540 12 , , , cord-028721-x6f26ahr 540 13 neuron neuron NN cord-028721-x6f26ahr 540 14 - - HYPH cord-028721-x6f26ahr 540 15 like like JJ cord-028721-x6f26ahr 540 16 cells cell NNS cord-028721-x6f26ahr 540 17 , , , cord-028721-x6f26ahr 540 18 mast mast NN cord-028721-x6f26ahr 540 19 cells cell NNS cord-028721-x6f26ahr 540 20 , , , cord-028721-x6f26ahr 540 21 blood blood NN cord-028721-x6f26ahr 540 22 vessels vessel NNS cord-028721-x6f26ahr 540 23 , , , cord-028721-x6f26ahr 540 24 lymphatic lymphatic JJ cord-028721-x6f26ahr 540 25 vessels vessel NNS cord-028721-x6f26ahr 540 26 , , , cord-028721-x6f26ahr 540 27 and and CC cord-028721-x6f26ahr 540 28 nerves nerve NNS cord-028721-x6f26ahr 540 29 , , , cord-028721-x6f26ahr 540 30 accounting account VBG cord-028721-x6f26ahr 540 31 for for IN cord-028721-x6f26ahr 540 32 12 12 CD cord-028721-x6f26ahr 540 33 - - SYM cord-028721-x6f26ahr 540 34 20 20 CD cord-028721-x6f26ahr 540 35 % % NN cord-028721-x6f26ahr 540 36 of of IN cord-028721-x6f26ahr 540 37 testicular testicular JJ cord-028721-x6f26ahr 540 38 volume volume NN cord-028721-x6f26ahr 540 39 . . . cord-028721-x6f26ahr 541 1 183 183 CD cord-028721-x6f26ahr 541 2 _SP cord-028721-x6f26ahr 542 1 The the DT cord-028721-x6f26ahr 542 2 most most RBS cord-028721-x6f26ahr 542 3 numerous numerous JJ cord-028721-x6f26ahr 542 4 connective connective JJ cord-028721-x6f26ahr 542 5 tissue tissue NN cord-028721-x6f26ahr 542 6 cells cell NNS cord-028721-x6f26ahr 542 7 are be VBP cord-028721-x6f26ahr 542 8 fi fi IN cord-028721-x6f26ahr 542 9 broblasts broblasts NNP cord-028721-x6f26ahr 542 10 and and CC cord-028721-x6f26ahr 542 11 myofi myofi NNP cord-028721-x6f26ahr 542 12 broblasts broblasts NNP cord-028721-x6f26ahr 542 13 . . . cord-028721-x6f26ahr 543 1 The the DT cord-028721-x6f26ahr 543 2 former former JJ cord-028721-x6f26ahr 543 3 are be VBP cord-028721-x6f26ahr 543 4 also also RB cord-028721-x6f26ahr 543 5 known know VBN cord-028721-x6f26ahr 543 6 as as IN cord-028721-x6f26ahr 543 7 interstitial interstitial JJ cord-028721-x6f26ahr 543 8 dendritic dendritic JJ cord-028721-x6f26ahr 543 9 cells cell NNS cord-028721-x6f26ahr 543 10 or or CC cord-028721-x6f26ahr 543 11 CD34-positive cd34-positive CD cord-028721-x6f26ahr 543 12 stromal stromal NN cord-028721-x6f26ahr 543 13 cells cell NNS cord-028721-x6f26ahr 543 14 . . . cord-028721-x6f26ahr 544 1 They -PRON- PRP cord-028721-x6f26ahr 544 2 display display VBP cord-028721-x6f26ahr 544 3 a a DT cord-028721-x6f26ahr 544 4 network network NN cord-028721-x6f26ahr 544 5 around around IN cord-028721-x6f26ahr 544 6 the the DT cord-028721-x6f26ahr 544 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 544 8 tubules tubule NNS cord-028721-x6f26ahr 544 9 and and CC cord-028721-x6f26ahr 544 10 Leydig Leydig NNP cord-028721-x6f26ahr 544 11 cells cell NNS cord-028721-x6f26ahr 544 12 , , , cord-028721-x6f26ahr 544 13 and and CC cord-028721-x6f26ahr 544 14 also also RB cord-028721-x6f26ahr 544 15 form form VB cord-028721-x6f26ahr 544 16 the the DT cord-028721-x6f26ahr 544 17 outermost outermost JJ cord-028721-x6f26ahr 544 18 layers layer NNS cord-028721-x6f26ahr 544 19 of of IN cord-028721-x6f26ahr 544 20 the the DT cord-028721-x6f26ahr 544 21 tubular tubular JJ cord-028721-x6f26ahr 544 22 wall wall NN cord-028721-x6f26ahr 544 23 . . . cord-028721-x6f26ahr 545 1 184 184 CD cord-028721-x6f26ahr 546 1 This this DT cord-028721-x6f26ahr 546 2 distribution distribution NN cord-028721-x6f26ahr 546 3 begins begin VBZ cord-028721-x6f26ahr 546 4 in in IN cord-028721-x6f26ahr 546 5 fetal fetal JJ cord-028721-x6f26ahr 546 6 life life NN cord-028721-x6f26ahr 546 7 . . . cord-028721-x6f26ahr 547 1 Some some DT cord-028721-x6f26ahr 547 2 of of IN cord-028721-x6f26ahr 547 3 these these DT cord-028721-x6f26ahr 547 4 cells cell NNS cord-028721-x6f26ahr 547 5 are be VBP cord-028721-x6f26ahr 547 6 in in IN cord-028721-x6f26ahr 547 7 contact contact NN cord-028721-x6f26ahr 547 8 with with IN cord-028721-x6f26ahr 547 9 typical typical JJ cord-028721-x6f26ahr 547 10 macrophages macrophage NNS cord-028721-x6f26ahr 547 11 , , , cord-028721-x6f26ahr 547 12 so so CC cord-028721-x6f26ahr 547 13 it -PRON- PRP cord-028721-x6f26ahr 547 14 has have VBZ cord-028721-x6f26ahr 547 15 been be VBN cord-028721-x6f26ahr 547 16 suggested suggest VBN cord-028721-x6f26ahr 547 17 that that IN cord-028721-x6f26ahr 547 18 they -PRON- PRP cord-028721-x6f26ahr 547 19 might may MD cord-028721-x6f26ahr 547 20 be be VB cord-028721-x6f26ahr 547 21 involved involve VBN cord-028721-x6f26ahr 547 22 in in IN cord-028721-x6f26ahr 547 23 immune immune JJ cord-028721-x6f26ahr 547 24 surveillance surveillance NN cord-028721-x6f26ahr 547 25 . . . cord-028721-x6f26ahr 548 1 Myofibroblasts myofibroblast NNS cord-028721-x6f26ahr 548 2 , , , cord-028721-x6f26ahr 548 3 in in IN cord-028721-x6f26ahr 548 4 addition addition NN cord-028721-x6f26ahr 548 5 to to IN cord-028721-x6f26ahr 548 6 their -PRON- PRP$ cord-028721-x6f26ahr 548 7 presence presence NN cord-028721-x6f26ahr 548 8 in in IN cord-028721-x6f26ahr 548 9 the the DT cord-028721-x6f26ahr 548 10 inner inner JJ cord-028721-x6f26ahr 548 11 layer layer NN cord-028721-x6f26ahr 548 12 of of IN cord-028721-x6f26ahr 548 13 the the DT cord-028721-x6f26ahr 548 14 tubular tubular JJ cord-028721-x6f26ahr 548 15 wall wall NN cord-028721-x6f26ahr 548 16 , , , cord-028721-x6f26ahr 548 17 are be VBP cord-028721-x6f26ahr 548 18 numerous numerous JJ cord-028721-x6f26ahr 548 19 in in IN cord-028721-x6f26ahr 548 20 the the DT cord-028721-x6f26ahr 548 21 tunica tunica NNP cord-028721-x6f26ahr 548 22 albuginea albuginea NNP cord-028721-x6f26ahr 548 23 . . . cord-028721-x6f26ahr 549 1 Leydig leydig NN cord-028721-x6f26ahr 549 2 cells cell NNS cord-028721-x6f26ahr 549 3 are be VBP cord-028721-x6f26ahr 549 4 distributed distribute VBN cord-028721-x6f26ahr 549 5 single single JJ cord-028721-x6f26ahr 549 6 or or CC cord-028721-x6f26ahr 549 7 in in IN cord-028721-x6f26ahr 549 8 clusters cluster NNS cord-028721-x6f26ahr 549 9 , , , cord-028721-x6f26ahr 549 10 and and CC cord-028721-x6f26ahr 549 11 form form VBP cord-028721-x6f26ahr 549 12 about about RB cord-028721-x6f26ahr 549 13 3.8 3.8 CD cord-028721-x6f26ahr 549 14 % % NN cord-028721-x6f26ahr 549 15 of of IN cord-028721-x6f26ahr 549 16 testicular testicular JJ cord-028721-x6f26ahr 549 17 volume volume NN cord-028721-x6f26ahr 549 18 . . . cord-028721-x6f26ahr 550 1 Most Most JJS cord-028721-x6f26ahr 550 2 are be VBP cord-028721-x6f26ahr 550 3 in in IN cord-028721-x6f26ahr 550 4 the the DT cord-028721-x6f26ahr 550 5 testicular testicular NNP cord-028721-x6f26ahr 550 6 interstitium interstitium NN cord-028721-x6f26ahr 550 7 , , , cord-028721-x6f26ahr 550 8 although although IN cord-028721-x6f26ahr 550 9 they -PRON- PRP cord-028721-x6f26ahr 550 10 may may MD cord-028721-x6f26ahr 550 11 also also RB cord-028721-x6f26ahr 550 12 be be VB cord-028721-x6f26ahr 550 13 found find VBN cord-028721-x6f26ahr 550 14 in in IN cord-028721-x6f26ahr 550 15 the the DT cord-028721-x6f26ahr 550 16 tubular tubular JJ cord-028721-x6f26ahr 550 17 tunica tunica NNP cord-028721-x6f26ahr 550 18 propria propria FW cord-028721-x6f26ahr 550 19 , , , cord-028721-x6f26ahr 550 20 mediastinum mediastinum FW cord-028721-x6f26ahr 550 21 testis testis NN cord-028721-x6f26ahr 550 22 , , , cord-028721-x6f26ahr 550 23 tunica tunica NNP cord-028721-x6f26ahr 550 24 albuginea albuginea NNP cord-028721-x6f26ahr 550 25 , , , cord-028721-x6f26ahr 550 26 epididymis epididymis NN cord-028721-x6f26ahr 550 27 , , , cord-028721-x6f26ahr 550 28 and and CC cord-028721-x6f26ahr 550 29 spermatic spermatic JJ cord-028721-x6f26ahr 550 30 cord cord NN cord-028721-x6f26ahr 550 31 . . . cord-028721-x6f26ahr 551 1 Extratesticular Extratesticular NNP cord-028721-x6f26ahr 551 2 Leydig Leydig NNP cord-028721-x6f26ahr 551 3 cells cell NNS cord-028721-x6f26ahr 551 4 are be VBP cord-028721-x6f26ahr 551 5 usually usually RB cord-028721-x6f26ahr 551 6 seen see VBN cord-028721-x6f26ahr 551 7 within within IN cord-028721-x6f26ahr 551 8 or or CC cord-028721-x6f26ahr 551 9 near near IN cord-028721-x6f26ahr 551 10 nerve nerve NN cord-028721-x6f26ahr 551 11 trunks trunk NNS cord-028721-x6f26ahr 551 12 . . . cord-028721-x6f26ahr 552 1 [ [ -LRB- cord-028721-x6f26ahr 552 2 185 185 CD cord-028721-x6f26ahr 552 3 ] ] -RRB- cord-028721-x6f26ahr 552 4 [ [ -LRB- cord-028721-x6f26ahr 552 5 186 186 CD cord-028721-x6f26ahr 552 6 ] ] -RRB- cord-028721-x6f26ahr 552 7 [ [ -LRB- cord-028721-x6f26ahr 552 8 187 187 CD cord-028721-x6f26ahr 552 9 ] ] -RRB- cord-028721-x6f26ahr 553 1 Leydig leydig NN cord-028721-x6f26ahr 553 2 cells cell NNS cord-028721-x6f26ahr 553 3 have have VBP cord-028721-x6f26ahr 553 4 spherical spherical JJ cord-028721-x6f26ahr 553 5 eccentric eccentric JJ cord-028721-x6f26ahr 553 6 nuclei nucleus NNS cord-028721-x6f26ahr 553 7 with with IN cord-028721-x6f26ahr 553 8 one one CD cord-028721-x6f26ahr 553 9 or or CC cord-028721-x6f26ahr 553 10 two two CD cord-028721-x6f26ahr 553 11 eccentric eccentric JJ cord-028721-x6f26ahr 553 12 nucleoli nucleolus NNS cord-028721-x6f26ahr 553 13 and and CC cord-028721-x6f26ahr 553 14 prominent prominent JJ cord-028721-x6f26ahr 553 15 nuclear nuclear JJ cord-028721-x6f26ahr 553 16 lamina lamina NN cord-028721-x6f26ahr 553 17 . . . cord-028721-x6f26ahr 554 1 The the DT cord-028721-x6f26ahr 554 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 554 3 is be VBZ cord-028721-x6f26ahr 554 4 abundant abundant JJ cord-028721-x6f26ahr 554 5 , , , cord-028721-x6f26ahr 554 6 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 554 7 , , , cord-028721-x6f26ahr 554 8 and and CC cord-028721-x6f26ahr 554 9 contains contain VBZ cord-028721-x6f26ahr 554 10 lipid lipid NN cord-028721-x6f26ahr 554 11 droplets droplet NNS cord-028721-x6f26ahr 554 12 and and CC cord-028721-x6f26ahr 554 13 lipofuscin lipofuscin NN cord-028721-x6f26ahr 554 14 granules granule NNS cord-028721-x6f26ahr 554 15 ( ( -LRB- cord-028721-x6f26ahr 554 16 residual residual JJ cord-028721-x6f26ahr 554 17 bodies body NNS cord-028721-x6f26ahr 554 18 ) ) -RRB- cord-028721-x6f26ahr 555 1 ( ( -LRB- cord-028721-x6f26ahr 555 2 Fig Fig NNP cord-028721-x6f26ahr 555 3 . . . cord-028721-x6f26ahr 555 4 12 12 CD cord-028721-x6f26ahr 555 5 - - SYM cord-028721-x6f26ahr 555 6 23 23 CD cord-028721-x6f26ahr 555 7 ) ) -RRB- cord-028721-x6f26ahr 555 8 . . . cord-028721-x6f26ahr 556 1 Reinke Reinke NNP cord-028721-x6f26ahr 556 2 's 's POS cord-028721-x6f26ahr 556 3 crystalloids crystalloid NNS cord-028721-x6f26ahr 556 4 are be VBP cord-028721-x6f26ahr 556 5 found find VBN cord-028721-x6f26ahr 556 6 only only RB cord-028721-x6f26ahr 556 7 in in IN cord-028721-x6f26ahr 556 8 the the DT cord-028721-x6f26ahr 556 9 Leydig Leydig NNP cord-028721-x6f26ahr 556 10 cells cell NNS cord-028721-x6f26ahr 556 11 of of IN cord-028721-x6f26ahr 556 12 adults adult NNS cord-028721-x6f26ahr 556 13 and and CC cord-028721-x6f26ahr 556 14 , , , cord-028721-x6f26ahr 556 15 although although IN cord-028721-x6f26ahr 556 16 it -PRON- PRP cord-028721-x6f26ahr 556 17 was be VBD cord-028721-x6f26ahr 556 18 believed believe VBN cord-028721-x6f26ahr 556 19 that that IN cord-028721-x6f26ahr 556 20 these these DT cord-028721-x6f26ahr 556 21 crystals crystal NNS cord-028721-x6f26ahr 556 22 were be VBD cord-028721-x6f26ahr 556 23 present present JJ cord-028721-x6f26ahr 556 24 exclusively exclusively RB cord-028721-x6f26ahr 556 25 in in IN cord-028721-x6f26ahr 556 26 humans human NNS cord-028721-x6f26ahr 556 27 , , , cord-028721-x6f26ahr 556 28 they -PRON- PRP cord-028721-x6f26ahr 556 29 have have VBP cord-028721-x6f26ahr 556 30 also also RB cord-028721-x6f26ahr 556 31 been be VBN cord-028721-x6f26ahr 556 32 observed observe VBN cord-028721-x6f26ahr 556 33 in in IN cord-028721-x6f26ahr 556 34 the the DT cord-028721-x6f26ahr 556 35 wild wild JJ cord-028721-x6f26ahr 556 36 bush bush NNP cord-028721-x6f26ahr 556 37 rat rat NN cord-028721-x6f26ahr 556 38 . . . cord-028721-x6f26ahr 557 1 Reinke Reinke NNP cord-028721-x6f26ahr 557 2 's 's POS cord-028721-x6f26ahr 557 3 crystalloids crystalloid NNS cord-028721-x6f26ahr 557 4 are be VBP cord-028721-x6f26ahr 557 5 up up IN cord-028721-x6f26ahr 557 6 to to TO cord-028721-x6f26ahr 557 7 20 20 CD cord-028721-x6f26ahr 557 8 µm µm NN cord-028721-x6f26ahr 557 9 long long JJ cord-028721-x6f26ahr 557 10 and and CC cord-028721-x6f26ahr 557 11 2 2 CD cord-028721-x6f26ahr 557 12 - - SYM cord-028721-x6f26ahr 557 13 3 3 CD cord-028721-x6f26ahr 557 14 µm µm NN cord-028721-x6f26ahr 557 15 wide wide JJ cord-028721-x6f26ahr 557 16 , , , cord-028721-x6f26ahr 557 17 consisting consist VBG cord-028721-x6f26ahr 557 18 of of IN cord-028721-x6f26ahr 557 19 a a DT cord-028721-x6f26ahr 557 20 complicated complicated JJ cord-028721-x6f26ahr 557 21 meshwork meshwork NN cord-028721-x6f26ahr 557 22 of of IN cord-028721-x6f26ahr 557 23 5 5 CD cord-028721-x6f26ahr 557 24 nm nm NN cord-028721-x6f26ahr 557 25 fi fi NNP cord-028721-x6f26ahr 557 26 laments lament VBZ cord-028721-x6f26ahr 557 27 with with IN cord-028721-x6f26ahr 557 28 a a DT cord-028721-x6f26ahr 557 29 trigonal trigonal JJ cord-028721-x6f26ahr 557 30 lattice lattice NN cord-028721-x6f26ahr 557 31 arrangement arrangement NN cord-028721-x6f26ahr 557 32 . . . cord-028721-x6f26ahr 558 1 Depending depend VBG cord-028721-x6f26ahr 558 2 on on IN cord-028721-x6f26ahr 558 3 the the DT cord-028721-x6f26ahr 558 4 plane plane NN cord-028721-x6f26ahr 558 5 of of IN cord-028721-x6f26ahr 558 6 section section NN cord-028721-x6f26ahr 558 7 , , , cord-028721-x6f26ahr 558 8 three three CD cord-028721-x6f26ahr 558 9 basic basic JJ cord-028721-x6f26ahr 558 10 aspects aspect NNS cord-028721-x6f26ahr 558 11 of of IN cord-028721-x6f26ahr 558 12 this this DT cord-028721-x6f26ahr 558 13 lattice lattice NN cord-028721-x6f26ahr 558 14 can can MD cord-028721-x6f26ahr 558 15 be be VB cord-028721-x6f26ahr 558 16 discerned discern VBN cord-028721-x6f26ahr 558 17 . . . cord-028721-x6f26ahr 559 1 Frequently frequently RB cord-028721-x6f26ahr 559 2 , , , cord-028721-x6f26ahr 559 3 the the DT cord-028721-x6f26ahr 559 4 crystalloids crystalloids NNP cord-028721-x6f26ahr 559 5 display display NN cord-028721-x6f26ahr 559 6 pale pale JJ cord-028721-x6f26ahr 559 7 lines line NNS cord-028721-x6f26ahr 559 8 , , , cord-028721-x6f26ahr 559 9 con- con- NN cord-028721-x6f26ahr 559 10 sidered sidere VBD cord-028721-x6f26ahr 559 11 to to TO cord-028721-x6f26ahr 559 12 be be VB cord-028721-x6f26ahr 559 13 potential potential JJ cord-028721-x6f26ahr 559 14 planes plane NNS cord-028721-x6f26ahr 559 15 of of IN cord-028721-x6f26ahr 559 16 cleavage cleavage NN cord-028721-x6f26ahr 559 17 . . . cord-028721-x6f26ahr 560 1 The the DT cord-028721-x6f26ahr 560 2 fi fi NN cord-028721-x6f26ahr 560 3 laments lament NNS cord-028721-x6f26ahr 560 4 are be VBP cord-028721-x6f26ahr 560 5 grouped group VBN cord-028721-x6f26ahr 560 6 into into IN cord-028721-x6f26ahr 560 7 19 19 CD cord-028721-x6f26ahr 560 8 nm nm JJ cord-028721-x6f26ahr 560 9 - - HYPH cord-028721-x6f26ahr 560 10 wide wide JJ cord-028721-x6f26ahr 560 11 hexagons hexagon NNS cord-028721-x6f26ahr 560 12 visible visible JJ cord-028721-x6f26ahr 560 13 on on IN cord-028721-x6f26ahr 560 14 cross cross NN cord-028721-x6f26ahr 560 15 - - NN cord-028721-x6f26ahr 560 16 section section NN cord-028721-x6f26ahr 560 17 . . . cord-028721-x6f26ahr 561 1 In in IN cord-028721-x6f26ahr 561 2 some some DT cord-028721-x6f26ahr 561 3 areas area NNS cord-028721-x6f26ahr 561 4 there there EX cord-028721-x6f26ahr 561 5 are be VBP cord-028721-x6f26ahr 561 6 aggregates aggregate NNS cord-028721-x6f26ahr 561 7 of of IN cord-028721-x6f26ahr 561 8 electron electron NN cord-028721-x6f26ahr 561 9 - - HYPH cord-028721-x6f26ahr 561 10 dense dense JJ cord-028721-x6f26ahr 561 11 , , , cord-028721-x6f26ahr 561 12 rodshaped rodshaped JJ cord-028721-x6f26ahr 561 13 structures structure NNS cord-028721-x6f26ahr 561 14 . . . cord-028721-x6f26ahr 562 1 Some some DT cord-028721-x6f26ahr 562 2 Leydig Leydig NNP cord-028721-x6f26ahr 562 3 cells cell NNS cord-028721-x6f26ahr 562 4 contain contain VBP cord-028721-x6f26ahr 562 5 other other JJ cord-028721-x6f26ahr 562 6 types type NNS cord-028721-x6f26ahr 562 7 of of IN cord-028721-x6f26ahr 562 8 paracrystalline paracrystalline NN cord-028721-x6f26ahr 562 9 inclusion inclusion NN cord-028721-x6f26ahr 562 10 , , , cord-028721-x6f26ahr 562 11 the the DT cord-028721-x6f26ahr 562 12 most most RBS cord-028721-x6f26ahr 562 13 common common JJ cord-028721-x6f26ahr 562 14 of of IN cord-028721-x6f26ahr 562 15 which which WDT cord-028721-x6f26ahr 562 16 consists consist VBZ cord-028721-x6f26ahr 562 17 of of IN cord-028721-x6f26ahr 562 18 multiple multiple JJ cord-028721-x6f26ahr 562 19 parallel parallel NN cord-028721-x6f26ahr 562 20 - - HYPH cord-028721-x6f26ahr 562 21 folded fold VBN cord-028721-x6f26ahr 562 22 laminae laminae NN cord-028721-x6f26ahr 562 23 . . . cord-028721-x6f26ahr 563 1 188 188 CD cord-028721-x6f26ahr 563 2 Leydig Leydig NNP cord-028721-x6f26ahr 563 3 cells cell NNS cord-028721-x6f26ahr 563 4 contain contain VBP cord-028721-x6f26ahr 563 5 abundant abundant JJ cord-028721-x6f26ahr 563 6 well well RB cord-028721-x6f26ahr 563 7 - - HYPH cord-028721-x6f26ahr 563 8 developed develop VBN cord-028721-x6f26ahr 563 9 smooth smooth JJ cord-028721-x6f26ahr 563 10 endoplasmic endoplasmic NN cord-028721-x6f26ahr 563 11 reticulum reticulum NN cord-028721-x6f26ahr 563 12 , , , cord-028721-x6f26ahr 563 13 pleomorphic pleomorphic JJ cord-028721-x6f26ahr 563 14 mitochondria mitochondrion NNS cord-028721-x6f26ahr 563 15 with with IN cord-028721-x6f26ahr 563 16 tubular tubular JJ cord-028721-x6f26ahr 563 17 cristae cristae NN cord-028721-x6f26ahr 563 18 , , , cord-028721-x6f26ahr 563 19 lysosomes lysosome NNS cord-028721-x6f26ahr 563 20 , , , cord-028721-x6f26ahr 563 21 and and CC cord-028721-x6f26ahr 563 22 peroxisomes peroxisome NNS cord-028721-x6f26ahr 563 23 . . . cord-028721-x6f26ahr 564 1 Leydig leydig NN cord-028721-x6f26ahr 564 2 cells cell NNS cord-028721-x6f26ahr 564 3 react react VBP cord-028721-x6f26ahr 564 4 with with IN cord-028721-x6f26ahr 564 5 antibodies antibody NNS cord-028721-x6f26ahr 564 6 to to IN cord-028721-x6f26ahr 564 7 S100 s100 NN cord-028721-x6f26ahr 564 8 protein protein NN cord-028721-x6f26ahr 564 9 and and CC cord-028721-x6f26ahr 564 10 neuron neuron NN cord-028721-x6f26ahr 564 11 - - HYPH cord-028721-x6f26ahr 564 12 specifi specifi NN cord-028721-x6f26ahr 564 13 c c NN cord-028721-x6f26ahr 564 14 enolase enolase NN cord-028721-x6f26ahr 564 15 . . . cord-028721-x6f26ahr 565 1 189 189 CD cord-028721-x6f26ahr 565 2 Leydig Leydig NNP cord-028721-x6f26ahr 565 3 cells cell NNS cord-028721-x6f26ahr 565 4 immunoreact immunoreact VBP cord-028721-x6f26ahr 565 5 to to IN cord-028721-x6f26ahr 565 6 LH LH NNP cord-028721-x6f26ahr 565 7 receptors receptor NNS cord-028721-x6f26ahr 565 8 , , , cord-028721-x6f26ahr 566 1 3-β 3-β CD cord-028721-x6f26ahr 566 2 - - HYPH cord-028721-x6f26ahr 566 3 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 566 4 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 566 5 ( ( -LRB- cord-028721-x6f26ahr 566 6 3-β 3-β CD cord-028721-x6f26ahr 566 7 - - HYPH cord-028721-x6f26ahr 566 8 ΗSD ΗSD NNP cord-028721-x6f26ahr 566 9 ) ) -RRB- cord-028721-x6f26ahr 566 10 , , , cord-028721-x6f26ahr 566 11 relaxin relaxin NN cord-028721-x6f26ahr 566 12 - - HYPH cord-028721-x6f26ahr 566 13 like like JJ cord-028721-x6f26ahr 566 14 factor factor NN cord-028721-x6f26ahr 566 15 , , , cord-028721-x6f26ahr 566 16 190 190 CD cord-028721-x6f26ahr 566 17 inhibin inhibin NN cord-028721-x6f26ahr 566 18 , , , cord-028721-x6f26ahr 566 19 and and CC cord-028721-x6f26ahr 566 20 ghrelin ghrelin NN cord-028721-x6f26ahr 566 21 . . . cord-028721-x6f26ahr 567 1 191 191 CD cord-028721-x6f26ahr 567 2 Relaxin Relaxin NNP cord-028721-x6f26ahr 567 3 - - HYPH cord-028721-x6f26ahr 567 4 like like JJ cord-028721-x6f26ahr 567 5 factor factor NN cord-028721-x6f26ahr 567 6 , , , cord-028721-x6f26ahr 567 7 also also RB cord-028721-x6f26ahr 567 8 known know VBN cord-028721-x6f26ahr 567 9 as as IN cord-028721-x6f26ahr 567 10 insulin insulin NN cord-028721-x6f26ahr 567 11 - - HYPH cord-028721-x6f26ahr 567 12 like like JJ cord-028721-x6f26ahr 567 13 factor factor NN cord-028721-x6f26ahr 567 14 3 3 CD cord-028721-x6f26ahr 567 15 ( ( -LRB- cord-028721-x6f26ahr 567 16 INSF-3 INSF-3 NNP cord-028721-x6f26ahr 567 17 ) ) -RRB- cord-028721-x6f26ahr 567 18 , , , cord-028721-x6f26ahr 567 19 is be VBZ cord-028721-x6f26ahr 567 20 a a DT cord-028721-x6f26ahr 567 21 peptide peptide NN cord-028721-x6f26ahr 567 22 that that WDT cord-028721-x6f26ahr 567 23 is be VBZ cord-028721-x6f26ahr 567 24 involved involve VBN cord-028721-x6f26ahr 567 25 in in IN cord-028721-x6f26ahr 567 26 testicular testicular JJ cord-028721-x6f26ahr 567 27 descent descent NN cord-028721-x6f26ahr 567 28 and and CC cord-028721-x6f26ahr 567 29 can can MD cord-028721-x6f26ahr 567 30 be be VB cord-028721-x6f26ahr 567 31 found find VBN cord-028721-x6f26ahr 567 32 in in IN cord-028721-x6f26ahr 567 33 serum serum NN cord-028721-x6f26ahr 567 34 . . . cord-028721-x6f26ahr 568 1 Its -PRON- PRP$ cord-028721-x6f26ahr 568 2 concentration concentration NN cord-028721-x6f26ahr 568 3 is be VBZ cord-028721-x6f26ahr 568 4 a a DT cord-028721-x6f26ahr 568 5 maker maker NN cord-028721-x6f26ahr 568 6 of of IN cord-028721-x6f26ahr 568 7 the the DT cord-028721-x6f26ahr 568 8 Leydig Leydig NNP cord-028721-x6f26ahr 568 9 cell cell NN cord-028721-x6f26ahr 568 10 functional functional JJ cord-028721-x6f26ahr 568 11 status status NN cord-028721-x6f26ahr 568 12 . . . cord-028721-x6f26ahr 569 1 As as IN cord-028721-x6f26ahr 569 2 occurs occur VBZ cord-028721-x6f26ahr 569 3 with with IN cord-028721-x6f26ahr 569 4 testosterone testosterone NN cord-028721-x6f26ahr 569 5 , , , cord-028721-x6f26ahr 569 6 INSF-3 insf-3 CD cord-028721-x6f26ahr 569 7 production production NN cord-028721-x6f26ahr 569 8 is be VBZ cord-028721-x6f26ahr 569 9 associated associate VBN cord-028721-x6f26ahr 569 10 with with IN cord-028721-x6f26ahr 569 11 that that DT cord-028721-x6f26ahr 569 12 of of IN cord-028721-x6f26ahr 569 13 LH LH NNP cord-028721-x6f26ahr 569 14 . . . cord-028721-x6f26ahr 570 1 192 192 CD cord-028721-x6f26ahr 570 2 Leydig Leydig NNP cord-028721-x6f26ahr 570 3 cells cell NNS cord-028721-x6f26ahr 570 4 immunoreact immunoreact VBP cord-028721-x6f26ahr 570 5 with with IN cord-028721-x6f26ahr 570 6 calretinin calretinin NNP cord-028721-x6f26ahr 570 7 , , , cord-028721-x6f26ahr 570 8 a a DT cord-028721-x6f26ahr 570 9 29 29 CD cord-028721-x6f26ahr 570 10 kDa kDa NNP cord-028721-x6f26ahr 570 11 calcium calcium NN cord-028721-x6f26ahr 570 12 - - HYPH cord-028721-x6f26ahr 570 13 binding bind VBG cord-028721-x6f26ahr 570 14 protein protein NN cord-028721-x6f26ahr 570 15 that that WDT cord-028721-x6f26ahr 570 16 has have VBZ cord-028721-x6f26ahr 570 17 a a DT cord-028721-x6f26ahr 570 18 buffering buffering NN cord-028721-x6f26ahr 570 19 effect effect NN cord-028721-x6f26ahr 570 20 to to TO cord-028721-x6f26ahr 570 21 avoid avoid VB cord-028721-x6f26ahr 570 22 abnormal abnormal JJ cord-028721-x6f26ahr 570 23 increases increase NNS cord-028721-x6f26ahr 570 24 in in IN cord-028721-x6f26ahr 570 25 intracellular intracellular JJ cord-028721-x6f26ahr 570 26 calcium calcium NN cord-028721-x6f26ahr 570 27 . . . cord-028721-x6f26ahr 571 1 193 193 CD cord-028721-x6f26ahr 571 2 Calretinin Calretinin NNP cord-028721-x6f26ahr 571 3 is be VBZ cord-028721-x6f26ahr 571 4 a a DT cord-028721-x6f26ahr 571 5 more more RBR cord-028721-x6f26ahr 571 6 sensitive sensitive JJ cord-028721-x6f26ahr 571 7 marker marker NN cord-028721-x6f26ahr 571 8 than than IN cord-028721-x6f26ahr 571 9 inhibin inhibin NNP cord-028721-x6f26ahr 571 10 , , , cord-028721-x6f26ahr 571 11 albeit albeit IN cord-028721-x6f26ahr 571 12 less less JJR cord-028721-x6f26ahr 571 13 specifi specifi NN cord-028721-x6f26ahr 571 14 c c NN cord-028721-x6f26ahr 572 1 ( ( -LRB- cord-028721-x6f26ahr 572 2 Fig Fig NNP cord-028721-x6f26ahr 572 3 . . . cord-028721-x6f26ahr 572 4 _SP cord-028721-x6f26ahr 572 5 12 12 CD cord-028721-x6f26ahr 572 6 - - SYM cord-028721-x6f26ahr 572 7 24 24 CD cord-028721-x6f26ahr 572 8 ) ) -RRB- cord-028721-x6f26ahr 572 9 . . . cord-028721-x6f26ahr 573 1 194 194 CD cord-028721-x6f26ahr 573 2 Leydig leydig NN cord-028721-x6f26ahr 573 3 cells cell NNS cord-028721-x6f26ahr 573 4 also also RB cord-028721-x6f26ahr 573 5 contain contain VBP cord-028721-x6f26ahr 573 6 VEGF VEGF NNP cord-028721-x6f26ahr 573 7 and and CC cord-028721-x6f26ahr 573 8 its -PRON- PRP$ cord-028721-x6f26ahr 573 9 two two CD cord-028721-x6f26ahr 573 10 receptors receptor NNS cord-028721-x6f26ahr 573 11 ( ( -LRB- cord-028721-x6f26ahr 573 12 Flt-1 Flt-1 NNP cord-028721-x6f26ahr 573 13 and and CC cord-028721-x6f26ahr 573 14 KDR KDR NNP cord-028721-x6f26ahr 573 15 ) ) -RRB- cord-028721-x6f26ahr 573 16 , , , cord-028721-x6f26ahr 573 17 and and CC cord-028721-x6f26ahr 573 18 endothelin endothelin NNP cord-028721-x6f26ahr 573 19 and and CC cord-028721-x6f26ahr 573 20 its -PRON- PRP$ cord-028721-x6f26ahr 573 21 two two CD cord-028721-x6f26ahr 573 22 receptors receptor NNS cord-028721-x6f26ahr 573 23 ( ( -LRB- cord-028721-x6f26ahr 573 24 α α NN cord-028721-x6f26ahr 573 25 and and CC cord-028721-x6f26ahr 573 26 β β NN cord-028721-x6f26ahr 573 27 ) ) -RRB- cord-028721-x6f26ahr 573 28 . . . cord-028721-x6f26ahr 574 1 VEGF VEGF NNP cord-028721-x6f26ahr 574 2 and and CC cord-028721-x6f26ahr 574 3 endothelin endothelin NNP cord-028721-x6f26ahr 574 4 are be VBP cord-028721-x6f26ahr 574 5 involved involve VBN cord-028721-x6f26ahr 574 6 in in IN cord-028721-x6f26ahr 574 7 paracrine paracrine NN cord-028721-x6f26ahr 574 8 and and CC cord-028721-x6f26ahr 574 9 autocrine autocrine JJ cord-028721-x6f26ahr 574 10 control control NN cord-028721-x6f26ahr 574 11 of of IN cord-028721-x6f26ahr 574 12 Leydig Leydig NNP cord-028721-x6f26ahr 574 13 cells cell NNS cord-028721-x6f26ahr 574 14 . . . cord-028721-x6f26ahr 575 1 Leydig leydig NN cord-028721-x6f26ahr 575 2 cells cell NNS cord-028721-x6f26ahr 575 3 near near IN cord-028721-x6f26ahr 575 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 575 5 tubules tubule NNS cord-028721-x6f26ahr 575 6 show show VBP cord-028721-x6f26ahr 575 7 immunoreactivity immunoreactivity NN cord-028721-x6f26ahr 575 8 for for IN cord-028721-x6f26ahr 575 9 glial glial JJ cord-028721-x6f26ahr 575 10 fi fi NNP cord-028721-x6f26ahr 575 11 brillar brillar JJ cord-028721-x6f26ahr 575 12 acid acid NN cord-028721-x6f26ahr 575 13 protein protein NN cord-028721-x6f26ahr 575 14 ( ( -LRB- cord-028721-x6f26ahr 575 15 GFAP GFAP NNP cord-028721-x6f26ahr 575 16 ) ) -RRB- cord-028721-x6f26ahr 575 17 195 195 CD cord-028721-x6f26ahr 576 1 ( ( -LRB- cord-028721-x6f26ahr 576 2 Fig Fig NNP cord-028721-x6f26ahr 576 3 . . . cord-028721-x6f26ahr 576 4 12 12 CD cord-028721-x6f26ahr 576 5 - - SYM cord-028721-x6f26ahr 576 6 24 24 CD cord-028721-x6f26ahr 576 7 ) ) -RRB- cord-028721-x6f26ahr 576 8 . . . cord-028721-x6f26ahr 577 1 The the DT cord-028721-x6f26ahr 577 2 demonstration demonstration NN cord-028721-x6f26ahr 577 3 of of IN cord-028721-x6f26ahr 577 4 several several JJ cord-028721-x6f26ahr 577 5 substances substance NNS cord-028721-x6f26ahr 577 6 that that WDT cord-028721-x6f26ahr 577 7 are be VBP cord-028721-x6f26ahr 577 8 characteristic characteristic JJ cord-028721-x6f26ahr 577 9 of of IN cord-028721-x6f26ahr 577 10 nerve nerve NN cord-028721-x6f26ahr 577 11 cells cell NNS cord-028721-x6f26ahr 577 12 , , , cord-028721-x6f26ahr 577 13 such such JJ cord-028721-x6f26ahr 577 14 as as IN cord-028721-x6f26ahr 577 15 substance substance NN cord-028721-x6f26ahr 577 16 P p NN cord-028721-x6f26ahr 577 17 , , , cord-028721-x6f26ahr 577 18 neurofi neurofi NNP cord-028721-x6f26ahr 577 19 lament lament NN cord-028721-x6f26ahr 577 20 triplet triplet NN cord-028721-x6f26ahr 577 21 proteins protein NNS cord-028721-x6f26ahr 577 22 ( ( -LRB- cord-028721-x6f26ahr 577 23 NF NF NNP cord-028721-x6f26ahr 577 24 - - HYPH cord-028721-x6f26ahr 577 25 L L NNP cord-028721-x6f26ahr 577 26 , , , cord-028721-x6f26ahr 577 27 NF NF NNP cord-028721-x6f26ahr 577 28 - - HYPH cord-028721-x6f26ahr 577 29 M M NNP cord-028721-x6f26ahr 577 30 and and CC cord-028721-x6f26ahr 577 31 NF NF NNP cord-028721-x6f26ahr 577 32 - - HYPH cord-028721-x6f26ahr 577 33 H H NNP cord-028721-x6f26ahr 577 34 ) ) -RRB- cord-028721-x6f26ahr 577 35 , , , cord-028721-x6f26ahr 577 36 and and CC cord-028721-x6f26ahr 577 37 the the DT cord-028721-x6f26ahr 577 38 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 577 39 observation observation NN cord-028721-x6f26ahr 577 40 of of IN cord-028721-x6f26ahr 577 41 microtubules microtubule NNS cord-028721-x6f26ahr 577 42 , , , cord-028721-x6f26ahr 577 43 intermediate intermediate JJ cord-028721-x6f26ahr 577 44 fi fi NN cord-028721-x6f26ahr 577 45 laments lament NNS cord-028721-x6f26ahr 577 46 , , , cord-028721-x6f26ahr 577 47 and and CC cord-028721-x6f26ahr 577 48 clear clear JJ cord-028721-x6f26ahr 577 49 and and CC cord-028721-x6f26ahr 577 50 dense dense JJ cord-028721-x6f26ahr 577 51 core core NN cord-028721-x6f26ahr 577 52 vesicles vesicle NNS cord-028721-x6f26ahr 577 53 , , , cord-028721-x6f26ahr 577 54 qualifi qualifi NNP cord-028721-x6f26ahr 577 55 es es NNP cord-028721-x6f26ahr 577 56 Leydig Leydig NNP cord-028721-x6f26ahr 577 57 cells cell NNS cord-028721-x6f26ahr 577 58 for for IN cord-028721-x6f26ahr 577 59 inclusion inclusion NN cord-028721-x6f26ahr 577 60 within within IN cord-028721-x6f26ahr 577 61 the the DT cord-028721-x6f26ahr 577 62 family family NN cord-028721-x6f26ahr 577 63 of of IN cord-028721-x6f26ahr 577 64 the the DT cord-028721-x6f26ahr 577 65 diffuse diffuse JJ cord-028721-x6f26ahr 577 66 endocrine endocrine JJ cord-028721-x6f26ahr 577 67 system system NN cord-028721-x6f26ahr 577 68 or or CC cord-028721-x6f26ahr 577 69 paraneurons paraneuron NNS cord-028721-x6f26ahr 577 70 . . . cord-028721-x6f26ahr 578 1 196 196 CD cord-028721-x6f26ahr 578 2 , , , cord-028721-x6f26ahr 578 3 197 197 CD cord-028721-x6f26ahr 578 4 Leydig Leydig NNP cord-028721-x6f26ahr 578 5 cells cell NNS cord-028721-x6f26ahr 578 6 of of IN cord-028721-x6f26ahr 578 7 the the DT cord-028721-x6f26ahr 578 8 adult adult NN cord-028721-x6f26ahr 578 9 testis testis NN cord-028721-x6f26ahr 578 10 originate originate VBP cord-028721-x6f26ahr 578 11 from from IN cord-028721-x6f26ahr 578 12 fi fi NNP cord-028721-x6f26ahr 578 13 broblastic broblastic JJ cord-028721-x6f26ahr 578 14 precursor precursor NN cord-028721-x6f26ahr 578 15 cells cell NNS cord-028721-x6f26ahr 578 16 at at IN cord-028721-x6f26ahr 578 17 puberty puberty NN cord-028721-x6f26ahr 578 18 under under IN cord-028721-x6f26ahr 578 19 LH LH NNP cord-028721-x6f26ahr 578 20 stimulation stimulation NN cord-028721-x6f26ahr 578 21 . . . cord-028721-x6f26ahr 579 1 198 198 CD cord-028721-x6f26ahr 579 2 Experimental experimental JJ cord-028721-x6f26ahr 579 3 studies study NNS cord-028721-x6f26ahr 579 4 in in IN cord-028721-x6f26ahr 579 5 rats rat NNS cord-028721-x6f26ahr 579 6 have have VBP cord-028721-x6f26ahr 579 7 shown show VBN cord-028721-x6f26ahr 579 8 that that IN cord-028721-x6f26ahr 579 9 adult adult NN cord-028721-x6f26ahr 579 10 Leydig Leydig NNP cord-028721-x6f26ahr 579 11 cells cell NNS cord-028721-x6f26ahr 579 12 differentiate differentiate VBP cord-028721-x6f26ahr 579 13 from from IN cord-028721-x6f26ahr 579 14 peritubular peritubular NNP cord-028721-x6f26ahr 579 15 cells cell NNS cord-028721-x6f26ahr 579 16 ( ( -LRB- cord-028721-x6f26ahr 579 17 myofi myofi NNP cord-028721-x6f26ahr 579 18 broblasts broblasts NNP cord-028721-x6f26ahr 579 19 and and CC cord-028721-x6f26ahr 579 20 blood blood NN cord-028721-x6f26ahr 579 21 capillary capillary JJ cord-028721-x6f26ahr 579 22 pericytes pericyte NNS cord-028721-x6f26ahr 579 23 ) ) -RRB- cord-028721-x6f26ahr 579 24 . . . cord-028721-x6f26ahr 580 1 Precursor Precursor NNP cord-028721-x6f26ahr 580 2 Leydig Leydig NNP cord-028721-x6f26ahr 580 3 cells cell NNS cord-028721-x6f26ahr 580 4 are be VBP cord-028721-x6f26ahr 580 5 reminiscent reminiscent JJ cord-028721-x6f26ahr 580 6 of of IN cord-028721-x6f26ahr 580 7 neural neural JJ cord-028721-x6f26ahr 580 8 stem stem NN cord-028721-x6f26ahr 580 9 cells cell NNS cord-028721-x6f26ahr 580 10 because because IN cord-028721-x6f26ahr 580 11 they -PRON- PRP cord-028721-x6f26ahr 580 12 express express VBP cord-028721-x6f26ahr 580 13 nestin nestin NNP cord-028721-x6f26ahr 580 14 and and CC cord-028721-x6f26ahr 580 15 eventually eventually RB cord-028721-x6f26ahr 580 16 acquire acquire VBP cord-028721-x6f26ahr 580 17 properties property NNS cord-028721-x6f26ahr 580 18 of of IN cord-028721-x6f26ahr 580 19 neurons neuron NNS cord-028721-x6f26ahr 580 20 and and CC cord-028721-x6f26ahr 580 21 glial glial JJ cord-028721-x6f26ahr 580 22 cells cell NNS cord-028721-x6f26ahr 580 23 . . . cord-028721-x6f26ahr 581 1 199 199 CD cord-028721-x6f26ahr 582 1 The the DT cord-028721-x6f26ahr 582 2 human human JJ cord-028721-x6f26ahr 582 3 testis testis NN cord-028721-x6f26ahr 582 4 contains contain VBZ cord-028721-x6f26ahr 582 5 about about RB cord-028721-x6f26ahr 582 6 200 200 CD cord-028721-x6f26ahr 582 7 million million CD cord-028721-x6f26ahr 582 8 Leydig Leydig NNP cord-028721-x6f26ahr 582 9 cells cell NNS cord-028721-x6f26ahr 582 10 . . . cord-028721-x6f26ahr 583 1 This this DT cord-028721-x6f26ahr 583 2 number number NN cord-028721-x6f26ahr 583 3 decreases decrease VBZ cord-028721-x6f26ahr 583 4 with with IN cord-028721-x6f26ahr 583 5 age age NN cord-028721-x6f26ahr 583 6 : : : cord-028721-x6f26ahr 583 7 the the DT cord-028721-x6f26ahr 583 8 testes testis NNS cord-028721-x6f26ahr 583 9 of of IN cord-028721-x6f26ahr 583 10 60-year 60-year JJ cord-028721-x6f26ahr 583 11 - - HYPH cord-028721-x6f26ahr 583 12 old old JJ cord-028721-x6f26ahr 583 13 men man NNS cord-028721-x6f26ahr 583 14 contain contain VBP cord-028721-x6f26ahr 583 15 about about IN cord-028721-x6f26ahr 583 16 half half PDT cord-028721-x6f26ahr 583 17 as as RB cord-028721-x6f26ahr 583 18 many many JJ cord-028721-x6f26ahr 583 19 as as IN cord-028721-x6f26ahr 583 20 those those DT cord-028721-x6f26ahr 583 21 of of IN cord-028721-x6f26ahr 583 22 20-year 20-year JJ cord-028721-x6f26ahr 583 23 - - HYPH cord-028721-x6f26ahr 583 24 old old JJ cord-028721-x6f26ahr 583 25 men man NNS cord-028721-x6f26ahr 583 26 . . . cord-028721-x6f26ahr 584 1 [ [ -LRB- cord-028721-x6f26ahr 584 2 202 202 CD cord-028721-x6f26ahr 584 3 ] ] -RRB- cord-028721-x6f26ahr 584 4 [ [ -LRB- cord-028721-x6f26ahr 584 5 203 203 CD cord-028721-x6f26ahr 584 6 ] ] -RRB- cord-028721-x6f26ahr 584 7 Mitotic mitotic NN cord-028721-x6f26ahr 584 8 fi fi NN cord-028721-x6f26ahr 584 9 gures gure NNS cord-028721-x6f26ahr 584 10 are be VBP cord-028721-x6f26ahr 584 11 seen see VBN cord-028721-x6f26ahr 584 12 occasionally occasionally RB cord-028721-x6f26ahr 584 13 in in IN cord-028721-x6f26ahr 584 14 normal normal JJ cord-028721-x6f26ahr 584 15 Leydig Leydig NNP cord-028721-x6f26ahr 584 16 cells cell NNS cord-028721-x6f26ahr 584 17 . . . cord-028721-x6f26ahr 585 1 204 204 CD cord-028721-x6f26ahr 585 2 Leydig leydig NN cord-028721-x6f26ahr 585 3 cells cell NNS cord-028721-x6f26ahr 585 4 are be VBP cord-028721-x6f26ahr 585 5 the the DT cord-028721-x6f26ahr 585 6 target target NN cord-028721-x6f26ahr 585 7 cell cell NN cord-028721-x6f26ahr 585 8 of of IN cord-028721-x6f26ahr 585 9 LH LH NNP cord-028721-x6f26ahr 585 10 , , , cord-028721-x6f26ahr 585 11 in in IN cord-028721-x6f26ahr 585 12 response response NN cord-028721-x6f26ahr 585 13 to to TO cord-028721-x6f26ahr 585 14 which which WDT cord-028721-x6f26ahr 585 15 they -PRON- PRP cord-028721-x6f26ahr 585 16 produce produce VBP cord-028721-x6f26ahr 585 17 testosterone testosterone NN cord-028721-x6f26ahr 585 18 and and CC cord-028721-x6f26ahr 585 19 other other JJ cord-028721-x6f26ahr 585 20 androgens androgen NNS cord-028721-x6f26ahr 585 21 necessary necessary JJ cord-028721-x6f26ahr 585 22 for for IN cord-028721-x6f26ahr 585 23 the the DT cord-028721-x6f26ahr 585 24 maintenance maintenance NN cord-028721-x6f26ahr 585 25 of of IN cord-028721-x6f26ahr 585 26 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 585 27 and and CC cord-028721-x6f26ahr 585 28 many many JJ cord-028721-x6f26ahr 585 29 structures structure NNS cord-028721-x6f26ahr 585 30 of of IN cord-028721-x6f26ahr 585 31 the the DT cord-028721-x6f26ahr 585 32 male male JJ cord-028721-x6f26ahr 585 33 genital genital JJ cord-028721-x6f26ahr 585 34 tract tract NN cord-028721-x6f26ahr 585 35 , , , cord-028721-x6f26ahr 585 36 as as RB cord-028721-x6f26ahr 585 37 well well RB cord-028721-x6f26ahr 585 38 as as IN cord-028721-x6f26ahr 585 39 other other JJ cord-028721-x6f26ahr 585 40 tissues tissue NNS cord-028721-x6f26ahr 585 41 such such JJ cord-028721-x6f26ahr 585 42 as as IN cord-028721-x6f26ahr 585 43 bone bone NN cord-028721-x6f26ahr 585 44 , , , cord-028721-x6f26ahr 585 45 muscle muscle NN cord-028721-x6f26ahr 585 46 , , , cord-028721-x6f26ahr 585 47 and and CC cord-028721-x6f26ahr 585 48 skin skin NN cord-028721-x6f26ahr 585 49 . . . cord-028721-x6f26ahr 586 1 [ [ -LRB- cord-028721-x6f26ahr 586 2 205 205 CD cord-028721-x6f26ahr 586 3 ] ] -RRB- cord-028721-x6f26ahr 586 4 [ [ -LRB- cord-028721-x6f26ahr 586 5 206 206 CD cord-028721-x6f26ahr 586 6 ] ] -RRB- cord-028721-x6f26ahr 587 1 [ [ -LRB- cord-028721-x6f26ahr 587 2 207 207 CD cord-028721-x6f26ahr 587 3 ] ] -RRB- cord-028721-x6f26ahr 587 4 [ [ -LRB- cord-028721-x6f26ahr 587 5 208 208 CD cord-028721-x6f26ahr 587 6 ] ] -RRB- cord-028721-x6f26ahr 588 1 Testosterone testosterone NN cord-028721-x6f26ahr 588 2 acts act VBZ cord-028721-x6f26ahr 588 3 on on IN cord-028721-x6f26ahr 588 4 the the DT cord-028721-x6f26ahr 588 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 588 6 cells cell NNS cord-028721-x6f26ahr 588 7 , , , cord-028721-x6f26ahr 588 8 either either CC cord-028721-x6f26ahr 588 9 directly directly RB cord-028721-x6f26ahr 588 10 209 209 CD cord-028721-x6f26ahr 588 11 or or CC cord-028721-x6f26ahr 588 12 via via IN cord-028721-x6f26ahr 588 13 the the DT cord-028721-x6f26ahr 588 14 P p NN cord-028721-x6f26ahr 588 15 - - HYPH cord-028721-x6f26ahr 588 16 mod mod NN cord-028721-x6f26ahr 588 17 - - HYPH cord-028721-x6f26ahr 588 18 S s NN cord-028721-x6f26ahr 588 19 factor factor NN cord-028721-x6f26ahr 588 20 secreted secrete VBN cord-028721-x6f26ahr 588 21 by by IN cord-028721-x6f26ahr 588 22 the the DT cord-028721-x6f26ahr 588 23 myofi myofi NNP cord-028721-x6f26ahr 588 24 broblasts broblasts NNP cord-028721-x6f26ahr 588 25 in in IN cord-028721-x6f26ahr 588 26 the the DT cord-028721-x6f26ahr 588 27 tunica tunica NNP cord-028721-x6f26ahr 588 28 propria propria FW cord-028721-x6f26ahr 588 29 . . . cord-028721-x6f26ahr 589 1 [ [ -LRB- cord-028721-x6f26ahr 589 2 210 210 CD cord-028721-x6f26ahr 589 3 ] ] -RRB- cord-028721-x6f26ahr 589 4 [ [ -LRB- cord-028721-x6f26ahr 589 5 211 211 CD cord-028721-x6f26ahr 589 6 ] ] -RRB- cord-028721-x6f26ahr 589 7 [ [ -LRB- cord-028721-x6f26ahr 589 8 212 212 CD cord-028721-x6f26ahr 589 9 ] ] -RRB- cord-028721-x6f26ahr 589 10 Leydig leydig NN cord-028721-x6f26ahr 589 11 cells cell NNS cord-028721-x6f26ahr 589 12 also also RB cord-028721-x6f26ahr 589 13 secrete secrete VBP cord-028721-x6f26ahr 589 14 numerous numerous JJ cord-028721-x6f26ahr 589 15 non non JJ cord-028721-x6f26ahr 589 16 - - JJ cord-028721-x6f26ahr 589 17 steroidal steroidal JJ cord-028721-x6f26ahr 589 18 factors factor NNS cord-028721-x6f26ahr 589 19 , , , cord-028721-x6f26ahr 589 20 including include VBG cord-028721-x6f26ahr 589 21 oxytocin oxytocin NNS cord-028721-x6f26ahr 589 22 , , , cord-028721-x6f26ahr 589 23 which which WDT cord-028721-x6f26ahr 589 24 acts act VBZ cord-028721-x6f26ahr 589 25 on on IN cord-028721-x6f26ahr 589 26 myofi myofi NNP cord-028721-x6f26ahr 589 27 broblasts broblasts NNP cord-028721-x6f26ahr 589 28 and and CC cord-028721-x6f26ahr 589 29 stimulates stimulate VBZ cord-028721-x6f26ahr 589 30 seminiferous seminiferous JJ cord-028721-x6f26ahr 589 31 tubule tubule NNP cord-028721-x6f26ahr 589 32 contraction contraction NN cord-028721-x6f26ahr 589 33 ; ; : cord-028721-x6f26ahr 589 34 β β NNP cord-028721-x6f26ahr 589 35 endorphin endorphin NN cord-028721-x6f26ahr 589 36 , , , cord-028721-x6f26ahr 589 37 which which WDT cord-028721-x6f26ahr 589 38 inhibits inhibit VBZ cord-028721-x6f26ahr 589 39 Sertoli sertoli JJ cord-028721-x6f26ahr 589 40 cell cell NN cord-028721-x6f26ahr 589 41 proliferation proliferation NN cord-028721-x6f26ahr 589 42 and and CC cord-028721-x6f26ahr 589 43 function function NN cord-028721-x6f26ahr 589 44 ; ; : cord-028721-x6f26ahr 589 45 EGF EGF NNP cord-028721-x6f26ahr 589 46 , , , cord-028721-x6f26ahr 589 47 which which WDT cord-028721-x6f26ahr 589 48 regulates regulate VBZ cord-028721-x6f26ahr 589 49 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 589 50 ; ; : cord-028721-x6f26ahr 589 51 and and CC cord-028721-x6f26ahr 589 52 other other JJ cord-028721-x6f26ahr 589 53 factors factor NNS cord-028721-x6f26ahr 589 54 with with IN cord-028721-x6f26ahr 589 55 less less RBR cord-028721-x6f26ahr 589 56 known know VBN cord-028721-x6f26ahr 589 57 actions action NNS cord-028721-x6f26ahr 589 58 , , , cord-028721-x6f26ahr 589 59 such such JJ cord-028721-x6f26ahr 589 60 as as IN cord-028721-x6f26ahr 589 61 angiotensin angiotensin NN cord-028721-x6f26ahr 589 62 , , , cord-028721-x6f26ahr 589 63 pro pro JJ cord-028721-x6f26ahr 589 64 - - JJ cord-028721-x6f26ahr 589 65 opiomelanocortin opiomelanocortin JJ cord-028721-x6f26ahr 589 66 , , , cord-028721-x6f26ahr 589 67 and and CC cord-028721-x6f26ahr 589 68 α α NN cord-028721-x6f26ahr 589 69 - - HYPH cord-028721-x6f26ahr 589 70 melanotropic melanotropic JJ cord-028721-x6f26ahr 589 71 stimulating stimulate VBG cord-028721-x6f26ahr 589 72 hormone hormone NN cord-028721-x6f26ahr 590 1 ( ( -LRB- cord-028721-x6f26ahr 590 2 Table Table NNP cord-028721-x6f26ahr 590 3 12 12 CD cord-028721-x6f26ahr 590 4 - - SYM cord-028721-x6f26ahr 590 5 4 4 CD cord-028721-x6f26ahr 590 6 ) ) -RRB- cord-028721-x6f26ahr 590 7 . . . cord-028721-x6f26ahr 591 1 Together together RB cord-028721-x6f26ahr 591 2 with with IN cord-028721-x6f26ahr 591 3 Sertoli Sertoli NNP cord-028721-x6f26ahr 591 4 cells cell NNS cord-028721-x6f26ahr 591 5 , , , cord-028721-x6f26ahr 591 6 peritubular peritubular NNP cord-028721-x6f26ahr 591 7 cells cell NNS cord-028721-x6f26ahr 591 8 , , , cord-028721-x6f26ahr 591 9 and and CC cord-028721-x6f26ahr 591 10 endothelial endothelial JJ cord-028721-x6f26ahr 591 11 cells cell NNS cord-028721-x6f26ahr 591 12 , , , cord-028721-x6f26ahr 591 13 Leydig leydig NN cord-028721-x6f26ahr 591 14 cells cell NNS cord-028721-x6f26ahr 591 15 produce produce VBP cord-028721-x6f26ahr 591 16 nitric nitric NN cord-028721-x6f26ahr 591 17 oxide oxide NN cord-028721-x6f26ahr 591 18 , , , cord-028721-x6f26ahr 591 19 which which WDT cord-028721-x6f26ahr 591 20 has have VBZ cord-028721-x6f26ahr 591 21 a a DT cord-028721-x6f26ahr 591 22 relaxing relaxing JJ cord-028721-x6f26ahr 591 23 effect effect NN cord-028721-x6f26ahr 591 24 on on IN cord-028721-x6f26ahr 591 25 smooth smooth JJ cord-028721-x6f26ahr 591 26 muscle muscle NN cord-028721-x6f26ahr 591 27 . . . cord-028721-x6f26ahr 592 1 213 213 CD cord-028721-x6f26ahr 592 2 Leydig Leydig NNP cord-028721-x6f26ahr 592 3 cells cell NNS cord-028721-x6f26ahr 592 4 are be VBP cord-028721-x6f26ahr 592 5 associated associate VBN cord-028721-x6f26ahr 592 6 with with IN cord-028721-x6f26ahr 592 7 cholinergic cholinergic JJ cord-028721-x6f26ahr 592 8 and and CC cord-028721-x6f26ahr 592 9 adrenergic adrenergic JJ cord-028721-x6f26ahr 592 10 nerve nerve NN cord-028721-x6f26ahr 592 11 fi fi NN cord-028721-x6f26ahr 592 12 bers ber NNS cord-028721-x6f26ahr 592 13 . . . cord-028721-x6f26ahr 593 1 186 186 CD cord-028721-x6f26ahr 593 2 Varicosities varicosity NNS cord-028721-x6f26ahr 593 3 containing contain VBG cord-028721-x6f26ahr 593 4 synaptic synaptic JJ cord-028721-x6f26ahr 593 5 vesicles vesicle NNS cord-028721-x6f26ahr 593 6 in in IN cord-028721-x6f26ahr 593 7 the the DT cord-028721-x6f26ahr 593 8 proximity proximity NN cord-028721-x6f26ahr 593 9 of of IN cord-028721-x6f26ahr 593 10 Leydig Leydig NNP cord-028721-x6f26ahr 593 11 cells cell NNS cord-028721-x6f26ahr 593 12 and and CC cord-028721-x6f26ahr 593 13 nerve nerve NN cord-028721-x6f26ahr 593 14 endings ending NNS cord-028721-x6f26ahr 593 15 in in IN cord-028721-x6f26ahr 593 16 direct direct JJ cord-028721-x6f26ahr 593 17 contact contact NN cord-028721-x6f26ahr 593 18 with with IN cord-028721-x6f26ahr 593 19 Leydig Leydig NNP cord-028721-x6f26ahr 593 20 cells cell NNS cord-028721-x6f26ahr 593 21 have have VBP cord-028721-x6f26ahr 593 22 been be VBN cord-028721-x6f26ahr 593 23 reported report VBN cord-028721-x6f26ahr 593 24 , , , cord-028721-x6f26ahr 593 25 although although IN cord-028721-x6f26ahr 593 26 the the DT cord-028721-x6f26ahr 593 27 functional functional JJ cord-028721-x6f26ahr 593 28 signifi signifi NNP cord-028721-x6f26ahr 593 29 cance cance NN cord-028721-x6f26ahr 593 30 of of IN cord-028721-x6f26ahr 593 31 this this DT cord-028721-x6f26ahr 593 32 innervation innervation NN cord-028721-x6f26ahr 593 33 is be VBZ cord-028721-x6f26ahr 593 34 unknown unknown JJ cord-028721-x6f26ahr 593 35 . . . cord-028721-x6f26ahr 594 1 214 214 CD cord-028721-x6f26ahr 595 1 , , , cord-028721-x6f26ahr 595 2 215 215 CD cord-028721-x6f26ahr 595 3 Macrophages macrophage NNS cord-028721-x6f26ahr 595 4 , , , cord-028721-x6f26ahr 595 5 neuron neuron NN cord-028721-x6f26ahr 595 6 - - HYPH cord-028721-x6f26ahr 595 7 like like JJ cord-028721-x6f26ahr 595 8 cells cell NNS cord-028721-x6f26ahr 595 9 , , , cord-028721-x6f26ahr 595 10 and and CC cord-028721-x6f26ahr 595 11 mast mast NN cord-028721-x6f26ahr 595 12 cells cell NNS cord-028721-x6f26ahr 595 13 Macrophages macrophage NNS cord-028721-x6f26ahr 595 14 are be VBP cord-028721-x6f26ahr 595 15 a a DT cord-028721-x6f26ahr 595 16 normal normal JJ cord-028721-x6f26ahr 595 17 component component NN cord-028721-x6f26ahr 595 18 of of IN cord-028721-x6f26ahr 595 19 the the DT cord-028721-x6f26ahr 595 20 testis testis NN cord-028721-x6f26ahr 595 21 216 216 CD cord-028721-x6f26ahr 595 22 - - SYM cord-028721-x6f26ahr 595 23 218 218 CD cord-028721-x6f26ahr 595 24 and and CC cord-028721-x6f26ahr 595 25 can can MD cord-028721-x6f26ahr 595 26 be be VB cord-028721-x6f26ahr 595 27 classifi classifi NNP cord-028721-x6f26ahr 595 28 ed ed NN cord-028721-x6f26ahr 595 29 into into IN cord-028721-x6f26ahr 595 30 two two CD cord-028721-x6f26ahr 595 31 groups group NNS cord-028721-x6f26ahr 595 32 : : : cord-028721-x6f26ahr 595 33 resident resident NN cord-028721-x6f26ahr 595 34 and and CC cord-028721-x6f26ahr 595 35 activated activate VBN cord-028721-x6f26ahr 595 36 . . . cord-028721-x6f26ahr 596 1 Resident resident JJ cord-028721-x6f26ahr 596 2 macrophages macrophage NNS cord-028721-x6f26ahr 596 3 are be VBP cord-028721-x6f26ahr 596 4 an an DT cord-028721-x6f26ahr 596 5 essential essential JJ cord-028721-x6f26ahr 596 6 cell cell NN cord-028721-x6f26ahr 596 7 type type NN cord-028721-x6f26ahr 596 8 of of IN cord-028721-x6f26ahr 596 9 the the DT cord-028721-x6f26ahr 596 10 testicular testicular NNP cord-028721-x6f26ahr 596 11 interstitium interstitium NN cord-028721-x6f26ahr 596 12 ( ( -LRB- cord-028721-x6f26ahr 596 13 about about RB cord-028721-x6f26ahr 596 14 25 25 CD cord-028721-x6f26ahr 596 15 % % NN cord-028721-x6f26ahr 596 16 of of IN cord-028721-x6f26ahr 596 17 interstitial interstitial JJ cord-028721-x6f26ahr 596 18 cells cell NNS cord-028721-x6f26ahr 596 19 in in IN cord-028721-x6f26ahr 596 20 mouse mouse NN cord-028721-x6f26ahr 596 21 testis testis NN cord-028721-x6f26ahr 596 22 ) ) -RRB- cord-028721-x6f26ahr 596 23 . . . cord-028721-x6f26ahr 597 1 219 219 CD cord-028721-x6f26ahr 598 1 In in IN cord-028721-x6f26ahr 598 2 young young JJ cord-028721-x6f26ahr 598 3 adult adult NN cord-028721-x6f26ahr 598 4 men man NNS cord-028721-x6f26ahr 598 5 , , , cord-028721-x6f26ahr 598 6 there there EX cord-028721-x6f26ahr 598 7 is be VBZ cord-028721-x6f26ahr 598 8 one one CD cord-028721-x6f26ahr 598 9 macrophage macrophage NN cord-028721-x6f26ahr 598 10 per per IN cord-028721-x6f26ahr 598 11 10 10 CD cord-028721-x6f26ahr 598 12 - - SYM cord-028721-x6f26ahr 598 13 15 15 CD cord-028721-x6f26ahr 598 14 Leydig Leydig NNP cord-028721-x6f26ahr 598 15 cells cell NNS cord-028721-x6f26ahr 598 16 , , , cord-028721-x6f26ahr 598 17 and and CC cord-028721-x6f26ahr 598 18 this this DT cord-028721-x6f26ahr 598 19 number number NN cord-028721-x6f26ahr 598 20 increases increase VBZ cord-028721-x6f26ahr 598 21 with with IN cord-028721-x6f26ahr 598 22 age age NN cord-028721-x6f26ahr 598 23 . . . cord-028721-x6f26ahr 599 1 Macrophages macrophage NNS cord-028721-x6f26ahr 599 2 are be VBP cord-028721-x6f26ahr 599 3 closely closely RB cord-028721-x6f26ahr 599 4 related relate VBN cord-028721-x6f26ahr 599 5 to to IN cord-028721-x6f26ahr 599 6 Leydig leydig NN cord-028721-x6f26ahr 599 7 cells cell NNS cord-028721-x6f26ahr 599 8 and and CC cord-028721-x6f26ahr 599 9 play play VBP cord-028721-x6f26ahr 599 10 a a DT cord-028721-x6f26ahr 599 11 role role NN cord-028721-x6f26ahr 599 12 in in IN cord-028721-x6f26ahr 599 13 proliferation proliferation NN cord-028721-x6f26ahr 599 14 and and CC cord-028721-x6f26ahr 599 15 differentiation differentiation NN cord-028721-x6f26ahr 599 16 of of IN cord-028721-x6f26ahr 599 17 Leydig Leydig NNP cord-028721-x6f26ahr 599 18 cell cell NN cord-028721-x6f26ahr 599 19 fi fi NN cord-028721-x6f26ahr 599 20 broblastic broblastic JJ cord-028721-x6f26ahr 599 21 precursors precursor NNS cord-028721-x6f26ahr 599 22 . . . cord-028721-x6f26ahr 600 1 220 220 CD cord-028721-x6f26ahr 600 2 Interaction interaction NN cord-028721-x6f26ahr 600 3 between between IN cord-028721-x6f26ahr 600 4 macrophages macrophage NNS cord-028721-x6f26ahr 600 5 and and CC cord-028721-x6f26ahr 600 6 Leydig leydig NN cord-028721-x6f26ahr 600 7 cells cell NNS cord-028721-x6f26ahr 600 8 is be VBZ cord-028721-x6f26ahr 600 9 an an DT cord-028721-x6f26ahr 600 10 example example NN cord-028721-x6f26ahr 600 11 of of IN cord-028721-x6f26ahr 600 12 paracrine paracrine JJ cord-028721-x6f26ahr 600 13 function function NN cord-028721-x6f26ahr 600 14 . . . cord-028721-x6f26ahr 601 1 In in IN cord-028721-x6f26ahr 601 2 the the DT cord-028721-x6f26ahr 601 3 rat rat NN cord-028721-x6f26ahr 601 4 , , , cord-028721-x6f26ahr 601 5 testicular testicular JJ cord-028721-x6f26ahr 601 6 macrophages macrophage NNS cord-028721-x6f26ahr 601 7 produce produce VBP cord-028721-x6f26ahr 601 8 25-hydroxycholesterol 25-hydroxycholesterol CD cord-028721-x6f26ahr 601 9 ( ( -LRB- cord-028721-x6f26ahr 601 10 25-HC 25-hc CD cord-028721-x6f26ahr 601 11 ) ) -RRB- cord-028721-x6f26ahr 601 12 and and CC cord-028721-x6f26ahr 601 13 express express VB cord-028721-x6f26ahr 601 14 25-hydroxylase 25-hydroxylase CD cord-028721-x6f26ahr 601 15 , , , cord-028721-x6f26ahr 601 16 which which WDT cord-028721-x6f26ahr 601 17 transforms transform VBZ cord-028721-x6f26ahr 601 18 cholesterol cholesterol NN cord-028721-x6f26ahr 601 19 into into IN cord-028721-x6f26ahr 601 20 25-HC 25-hc CD cord-028721-x6f26ahr 601 21 . . . cord-028721-x6f26ahr 602 1 221,222 221,222 CD cord-028721-x6f26ahr 602 2 Activated activate VBN cord-028721-x6f26ahr 602 3 macrophages macrophage NNS cord-028721-x6f26ahr 602 4 produce produce VBP cord-028721-x6f26ahr 602 5 interleukins interleukin NNS cord-028721-x6f26ahr 602 6 1 1 CD cord-028721-x6f26ahr 602 7 and and CC cord-028721-x6f26ahr 602 8 6 6 CD cord-028721-x6f26ahr 602 9 ( ( -LRB- cord-028721-x6f26ahr 602 10 IL-1 IL-1 NNP cord-028721-x6f26ahr 602 11 and and CC cord-028721-x6f26ahr 602 12 IL-6 IL-6 NNP cord-028721-x6f26ahr 602 13 ) ) -RRB- cord-028721-x6f26ahr 602 14 , , , cord-028721-x6f26ahr 602 15 tumor tumor NN cord-028721-x6f26ahr 602 16 necrotizing necrotize VBG cord-028721-x6f26ahr 602 17 factor factor NN cord-028721-x6f26ahr 602 18 - - HYPH cord-028721-x6f26ahr 602 19 α α NN cord-028721-x6f26ahr 602 20 ( ( -LRB- cord-028721-x6f26ahr 602 21 TNF TNF NNP cord-028721-x6f26ahr 602 22 - - HYPH cord-028721-x6f26ahr 602 23 α α NNP cord-028721-x6f26ahr 602 24 ) ) -RRB- cord-028721-x6f26ahr 602 25 , , , cord-028721-x6f26ahr 602 26 and and CC cord-028721-x6f26ahr 602 27 transforming transform VBG cord-028721-x6f26ahr 602 28 growth growth NN cord-028721-x6f26ahr 602 29 factor factor NN cord-028721-x6f26ahr 602 30 - - HYPH cord-028721-x6f26ahr 602 31 α α NN cord-028721-x6f26ahr 602 32 ( ( -LRB- cord-028721-x6f26ahr 602 33 TGF TGF NNP cord-028721-x6f26ahr 602 34 - - HYPH cord-028721-x6f26ahr 602 35 α α NNP cord-028721-x6f26ahr 602 36 ) ) -RRB- cord-028721-x6f26ahr 602 37 . . . cord-028721-x6f26ahr 603 1 Immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 603 2 techniques technique NNS cord-028721-x6f26ahr 603 3 have have VBP cord-028721-x6f26ahr 603 4 demonstrated demonstrate VBN cord-028721-x6f26ahr 603 5 neuron neuron NN cord-028721-x6f26ahr 603 6 - - HYPH cord-028721-x6f26ahr 603 7 like like JJ cord-028721-x6f26ahr 603 8 cells cell NNS cord-028721-x6f26ahr 603 9 in in IN cord-028721-x6f26ahr 603 10 the the DT cord-028721-x6f26ahr 603 11 testicular testicular NNP cord-028721-x6f26ahr 603 12 interstitium interstitium NN cord-028721-x6f26ahr 603 13 . . . cord-028721-x6f26ahr 604 1 223 223 CD cord-028721-x6f26ahr 605 1 These these DT cord-028721-x6f26ahr 605 2 cells cell NNS cord-028721-x6f26ahr 605 3 are be VBP cord-028721-x6f26ahr 605 4 an an DT cord-028721-x6f26ahr 605 5 important important JJ cord-028721-x6f26ahr 605 6 source source NN cord-028721-x6f26ahr 605 7 of of IN cord-028721-x6f26ahr 605 8 intratesticular intratesticular NNP cord-028721-x6f26ahr 605 9 cate cate NNP cord-028721-x6f26ahr 605 10 - - HYPH cord-028721-x6f26ahr 605 11 cholamines cholamines NNP cord-028721-x6f26ahr 605 12 , , , cord-028721-x6f26ahr 605 13 which which WDT cord-028721-x6f26ahr 605 14 appear appear VBP cord-028721-x6f26ahr 605 15 to to TO cord-028721-x6f26ahr 605 16 be be VB cord-028721-x6f26ahr 605 17 increased increase VBN cord-028721-x6f26ahr 605 18 in in IN cord-028721-x6f26ahr 605 19 some some DT cord-028721-x6f26ahr 605 20 disorders disorder NNS cord-028721-x6f26ahr 605 21 such such JJ cord-028721-x6f26ahr 605 22 as as IN cord-028721-x6f26ahr 605 23 the the DT cord-028721-x6f26ahr 605 24 Sertoli sertoli JJ cord-028721-x6f26ahr 605 25 cell cell NN cord-028721-x6f26ahr 605 26 - - HYPH cord-028721-x6f26ahr 605 27 only only JJ cord-028721-x6f26ahr 605 28 syndrome syndrome NN cord-028721-x6f26ahr 605 29 , , , cord-028721-x6f26ahr 605 30 and and CC cord-028721-x6f26ahr 605 31 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 605 32 . . . cord-028721-x6f26ahr 606 1 Mast mast NN cord-028721-x6f26ahr 606 2 cells cell NNS cord-028721-x6f26ahr 606 3 are be VBP cord-028721-x6f26ahr 606 4 a a DT cord-028721-x6f26ahr 606 5 normal normal JJ cord-028721-x6f26ahr 606 6 component component NN cord-028721-x6f26ahr 606 7 of of IN cord-028721-x6f26ahr 606 8 the the DT cord-028721-x6f26ahr 606 9 testicular testicular NNP cord-028721-x6f26ahr 606 10 interstitium interstitium NN cord-028721-x6f26ahr 606 11 , , , cord-028721-x6f26ahr 606 12 where where WRB cord-028721-x6f26ahr 606 13 they -PRON- PRP cord-028721-x6f26ahr 606 14 are be VBP cord-028721-x6f26ahr 606 15 often often RB cord-028721-x6f26ahr 606 16 found find VBN cord-028721-x6f26ahr 606 17 near near IN cord-028721-x6f26ahr 606 18 blood blood NN cord-028721-x6f26ahr 606 19 vessels vessel NNS cord-028721-x6f26ahr 606 20 . . . cord-028721-x6f26ahr 607 1 Their -PRON- PRP$ cord-028721-x6f26ahr 607 2 number number NN cord-028721-x6f26ahr 607 3 increases increase NNS cord-028721-x6f26ahr 607 4 in in IN cord-028721-x6f26ahr 607 5 several several JJ cord-028721-x6f26ahr 607 6 diseases disease NNS cord-028721-x6f26ahr 607 7 . . . cord-028721-x6f26ahr 608 1 224 224 CD cord-028721-x6f26ahr 609 1 The the DT cord-028721-x6f26ahr 609 2 testis testis NN cord-028721-x6f26ahr 609 3 is be VBZ cord-028721-x6f26ahr 609 4 supplied supply VBN cord-028721-x6f26ahr 609 5 by by IN cord-028721-x6f26ahr 609 6 the the DT cord-028721-x6f26ahr 609 7 testicular testicular NN cord-028721-x6f26ahr 609 8 artery artery NN cord-028721-x6f26ahr 609 9 , , , cord-028721-x6f26ahr 609 10 which which WDT cord-028721-x6f26ahr 609 11 arises arise VBZ cord-028721-x6f26ahr 609 12 from from IN cord-028721-x6f26ahr 609 13 the the DT cord-028721-x6f26ahr 609 14 abdominal abdominal JJ cord-028721-x6f26ahr 609 15 aorta aorta NN cord-028721-x6f26ahr 609 16 . . . cord-028721-x6f26ahr 610 1 In in IN cord-028721-x6f26ahr 610 2 the the DT cord-028721-x6f26ahr 610 3 spermatic spermatic JJ cord-028721-x6f26ahr 610 4 cord cord NN cord-028721-x6f26ahr 610 5 , , , cord-028721-x6f26ahr 610 6 the the DT cord-028721-x6f26ahr 610 7 testicular testicular JJ cord-028721-x6f26ahr 610 8 artery artery NN cord-028721-x6f26ahr 610 9 gives give VBZ cord-028721-x6f26ahr 610 10 rise rise NN cord-028721-x6f26ahr 610 11 to to IN cord-028721-x6f26ahr 610 12 two two CD cord-028721-x6f26ahr 610 13 or or CC cord-028721-x6f26ahr 610 14 three three CD cord-028721-x6f26ahr 610 15 branches branch NNS cord-028721-x6f26ahr 610 16 that that WDT cord-028721-x6f26ahr 610 17 obliquely obliquely RB cord-028721-x6f26ahr 610 18 penetrate penetrate VBP cord-028721-x6f26ahr 610 19 the the DT cord-028721-x6f26ahr 610 20 tunica tunica NNP cord-028721-x6f26ahr 610 21 albuginea albuginea NNP cord-028721-x6f26ahr 610 22 testis testis NN cord-028721-x6f26ahr 610 23 and and CC cord-028721-x6f26ahr 610 24 to to IN cord-028721-x6f26ahr 610 25 multiple multiple JJ cord-028721-x6f26ahr 610 26 branches branch NNS cord-028721-x6f26ahr 610 27 that that WDT cord-028721-x6f26ahr 610 28 run run VBP cord-028721-x6f26ahr 610 29 along along IN cord-028721-x6f26ahr 610 30 the the DT cord-028721-x6f26ahr 610 31 intralobular intralobular NNP cord-028721-x6f26ahr 610 32 septa septa NNP cord-028721-x6f26ahr 610 33 of of IN cord-028721-x6f26ahr 610 34 the the DT cord-028721-x6f26ahr 610 35 testis testis NN cord-028721-x6f26ahr 610 36 . . . cord-028721-x6f26ahr 611 1 225 225 CD cord-028721-x6f26ahr 612 1 These these DT cord-028721-x6f26ahr 612 2 centripetal centripetal JJ cord-028721-x6f26ahr 612 3 arteries artery NNS cord-028721-x6f26ahr 612 4 lead lead VBP cord-028721-x6f26ahr 612 5 to to IN cord-028721-x6f26ahr 612 6 the the DT cord-028721-x6f26ahr 612 7 mediastinum mediastinum JJ cord-028721-x6f26ahr 612 8 testis testis NN cord-028721-x6f26ahr 612 9 . . . cord-028721-x6f26ahr 613 1 Along along IN cord-028721-x6f26ahr 613 2 their -PRON- PRP$ cord-028721-x6f26ahr 613 3 course course NN cord-028721-x6f26ahr 613 4 , , , cord-028721-x6f26ahr 613 5 the the DT cord-028721-x6f26ahr 613 6 centripetal centripetal JJ cord-028721-x6f26ahr 613 7 arteries artery NNS cord-028721-x6f26ahr 613 8 give give VBP cord-028721-x6f26ahr 613 9 off off RP cord-028721-x6f26ahr 613 10 branches branch NNS cord-028721-x6f26ahr 613 11 that that WDT cord-028721-x6f26ahr 613 12 abruptly abruptly RB cord-028721-x6f26ahr 613 13 reverse reverse VBP cord-028721-x6f26ahr 613 14 direction direction NN cord-028721-x6f26ahr 613 15 ; ; : cord-028721-x6f26ahr 613 16 these these DT cord-028721-x6f26ahr 613 17 are be VBP cord-028721-x6f26ahr 613 18 called call VBN cord-028721-x6f26ahr 613 19 centrifugal centrifugal JJ cord-028721-x6f26ahr 613 20 arteries artery NNS cord-028721-x6f26ahr 613 21 . . . cord-028721-x6f26ahr 614 1 At at IN cord-028721-x6f26ahr 614 2 puberty puberty NN cord-028721-x6f26ahr 614 3 , , , cord-028721-x6f26ahr 614 4 both both CC cord-028721-x6f26ahr 614 5 the the DT cord-028721-x6f26ahr 614 6 centripetal centripetal NN cord-028721-x6f26ahr 614 7 and and CC cord-028721-x6f26ahr 614 8 the the DT cord-028721-x6f26ahr 614 9 centrifugal centrifugal JJ cord-028721-x6f26ahr 614 10 arteries artery NNS cord-028721-x6f26ahr 614 11 develop develop VBP cord-028721-x6f26ahr 614 12 a a DT cord-028721-x6f26ahr 614 13 pronounced pronounce VBN cord-028721-x6f26ahr 614 14 spiral spiral JJ cord-028721-x6f26ahr 614 15 architecture architecture NN cord-028721-x6f26ahr 614 16 . . . cord-028721-x6f26ahr 615 1 226,227 226,227 CD cord-028721-x6f26ahr 616 1 The the DT cord-028721-x6f26ahr 616 2 centrifugal centrifugal JJ cord-028721-x6f26ahr 616 3 arteries artery NNS cord-028721-x6f26ahr 616 4 develop develop VBP cord-028721-x6f26ahr 616 5 additional additional JJ cord-028721-x6f26ahr 616 6 branches branch NNS cord-028721-x6f26ahr 616 7 in in IN cord-028721-x6f26ahr 616 8 the the DT cord-028721-x6f26ahr 616 9 testicular testicular NNP cord-028721-x6f26ahr 616 10 interstitium interstitium NN cord-028721-x6f26ahr 616 11 , , , cord-028721-x6f26ahr 616 12 giving give VBG cord-028721-x6f26ahr 616 13 rise rise NN cord-028721-x6f26ahr 616 14 to to IN cord-028721-x6f26ahr 616 15 arterioles arteriole NNS cord-028721-x6f26ahr 616 16 and and CC cord-028721-x6f26ahr 616 17 capillaries capillary NNS cord-028721-x6f26ahr 616 18 that that WDT cord-028721-x6f26ahr 616 19 form form VBP cord-028721-x6f26ahr 616 20 intertubular intertubular JJ cord-028721-x6f26ahr 616 21 plexuses plexus NNS cord-028721-x6f26ahr 616 22 , , , cord-028721-x6f26ahr 616 23 some some DT cord-028721-x6f26ahr 616 24 of of IN cord-028721-x6f26ahr 616 25 which which WDT cord-028721-x6f26ahr 616 26 are be VBP cord-028721-x6f26ahr 616 27 apposed appose VBN cord-028721-x6f26ahr 616 28 to to IN cord-028721-x6f26ahr 616 29 the the DT cord-028721-x6f26ahr 616 30 tunica tunica NNP cord-028721-x6f26ahr 616 31 propria propria FW cord-028721-x6f26ahr 616 32 . . . cord-028721-x6f26ahr 617 1 228 228 CD cord-028721-x6f26ahr 617 2 , , , cord-028721-x6f26ahr 617 3 229 229 CD cord-028721-x6f26ahr 617 4 Capillaries capillary NNS cord-028721-x6f26ahr 617 5 are be VBP cord-028721-x6f26ahr 617 6 of of IN cord-028721-x6f26ahr 617 7 the the DT cord-028721-x6f26ahr 617 8 continuous continuous JJ cord-028721-x6f26ahr 617 9 type type NN cord-028721-x6f26ahr 617 10 , , , cord-028721-x6f26ahr 617 11 except except IN cord-028721-x6f26ahr 617 12 for for IN cord-028721-x6f26ahr 617 13 the the DT cord-028721-x6f26ahr 617 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 617 15 tubule tubule NN cord-028721-x6f26ahr 617 16 capillaries capillary NNS cord-028721-x6f26ahr 617 17 , , , cord-028721-x6f26ahr 617 18 which which WDT cord-028721-x6f26ahr 617 19 are be VBP cord-028721-x6f26ahr 617 20 partially partially RB cord-028721-x6f26ahr 617 21 fenestrated fenestrate VBN cord-028721-x6f26ahr 617 22 , , , cord-028721-x6f26ahr 617 23 230 230 CD cord-028721-x6f26ahr 617 24 and and CC cord-028721-x6f26ahr 617 25 their -PRON- PRP$ cord-028721-x6f26ahr 617 26 endothelial endothelial JJ cord-028721-x6f26ahr 617 27 cells cell NNS cord-028721-x6f26ahr 617 28 are be VBP cord-028721-x6f26ahr 617 29 similar similar JJ cord-028721-x6f26ahr 617 30 to to IN cord-028721-x6f26ahr 617 31 those those DT cord-028721-x6f26ahr 617 32 of of IN cord-028721-x6f26ahr 617 33 brain brain NN cord-028721-x6f26ahr 617 34 capillaries capillary NNS cord-028721-x6f26ahr 617 35 , , , cord-028721-x6f26ahr 617 36 with with IN cord-028721-x6f26ahr 617 37 scant scant JJ cord-028721-x6f26ahr 617 38 pinocytosis pinocytosis NN cord-028721-x6f26ahr 617 39 , , , cord-028721-x6f26ahr 617 40 intercellular intercellular JJ cord-028721-x6f26ahr 617 41 junctions junction NNS cord-028721-x6f26ahr 617 42 of of IN cord-028721-x6f26ahr 617 43 the the DT cord-028721-x6f26ahr 617 44 fascia fascia NN cord-028721-x6f26ahr 617 45 adherens adherens NNP cord-028721-x6f26ahr 617 46 type type NN cord-028721-x6f26ahr 617 47 , , , cord-028721-x6f26ahr 617 48 and and CC cord-028721-x6f26ahr 617 49 low low JJ cord-028721-x6f26ahr 617 50 permeability permeability NN cord-028721-x6f26ahr 617 51 . . . cord-028721-x6f26ahr 618 1 The the DT cord-028721-x6f26ahr 618 2 mediastinum mediastinum NN cord-028721-x6f26ahr 618 3 testis testis NN cord-028721-x6f26ahr 618 4 is be VBZ cord-028721-x6f26ahr 618 5 poorly poorly RB cord-028721-x6f26ahr 618 6 vascularized vascularized JJ cord-028721-x6f26ahr 618 7 . . . cord-028721-x6f26ahr 619 1 The the DT cord-028721-x6f26ahr 619 2 inner inner JJ cord-028721-x6f26ahr 619 3 two two CD cord-028721-x6f26ahr 619 4 - - HYPH cord-028721-x6f26ahr 619 5 thirds third NNS cord-028721-x6f26ahr 619 6 of of IN cord-028721-x6f26ahr 619 7 the the DT cord-028721-x6f26ahr 619 8 testicular testicular JJ cord-028721-x6f26ahr 619 9 parenchyma parenchyma NN cord-028721-x6f26ahr 619 10 is be VBZ cord-028721-x6f26ahr 619 11 drained drain VBN cord-028721-x6f26ahr 619 12 by by IN cord-028721-x6f26ahr 619 13 veins vein NNS cord-028721-x6f26ahr 619 14 that that WDT cord-028721-x6f26ahr 619 15 follow follow VBP cord-028721-x6f26ahr 619 16 the the DT cord-028721-x6f26ahr 619 17 interlobular interlobular NNP cord-028721-x6f26ahr 619 18 septa septa NNP cord-028721-x6f26ahr 619 19 to to IN cord-028721-x6f26ahr 619 20 the the DT cord-028721-x6f26ahr 619 21 mediastinum mediastinum FW cord-028721-x6f26ahr 619 22 testis testis NN cord-028721-x6f26ahr 619 23 ( ( -LRB- cord-028721-x6f26ahr 619 24 centripetal centripetal JJ cord-028721-x6f26ahr 619 25 veins vein NNS cord-028721-x6f26ahr 619 26 ) ) -RRB- cord-028721-x6f26ahr 619 27 . . . cord-028721-x6f26ahr 620 1 The the DT cord-028721-x6f26ahr 620 2 outer outer JJ cord-028721-x6f26ahr 620 3 third third NN cord-028721-x6f26ahr 620 4 is be VBZ cord-028721-x6f26ahr 620 5 drained drain VBN cord-028721-x6f26ahr 620 6 by by IN cord-028721-x6f26ahr 620 7 veins vein NNS cord-028721-x6f26ahr 620 8 that that WDT cord-028721-x6f26ahr 620 9 lead lead VBP cord-028721-x6f26ahr 620 10 to to IN cord-028721-x6f26ahr 620 11 the the DT cord-028721-x6f26ahr 620 12 tunica tunica NNP cord-028721-x6f26ahr 620 13 albuginea albuginea NNP cord-028721-x6f26ahr 620 14 ( ( -LRB- cord-028721-x6f26ahr 620 15 centrifugal centrifugal JJ cord-028721-x6f26ahr 620 16 veins vein NNS cord-028721-x6f26ahr 620 17 ) ) -RRB- cord-028721-x6f26ahr 620 18 . . . cord-028721-x6f26ahr 621 1 Both both DT cord-028721-x6f26ahr 621 2 centripetal centripetal JJ cord-028721-x6f26ahr 621 3 and and CC cord-028721-x6f26ahr 621 4 centrifugal centrifugal JJ cord-028721-x6f26ahr 621 5 veins vein NNS cord-028721-x6f26ahr 621 6 join join VBP cord-028721-x6f26ahr 621 7 to to TO cord-028721-x6f26ahr 621 8 form form VB cord-028721-x6f26ahr 621 9 the the DT cord-028721-x6f26ahr 621 10 pampiniform pampiniform NNP cord-028721-x6f26ahr 621 11 plexus plexus NNP cord-028721-x6f26ahr 621 12 , , , cord-028721-x6f26ahr 621 13 which which WDT cord-028721-x6f26ahr 621 14 drains drain VBZ cord-028721-x6f26ahr 621 15 the the DT cord-028721-x6f26ahr 621 16 testis testis NN cord-028721-x6f26ahr 621 17 via via IN cord-028721-x6f26ahr 621 18 the the DT cord-028721-x6f26ahr 621 19 spermatic spermatic JJ cord-028721-x6f26ahr 621 20 cord cord NN cord-028721-x6f26ahr 621 21 . . . cord-028721-x6f26ahr 622 1 Lymphatic lymphatic JJ cord-028721-x6f26ahr 622 2 vessels vessel NNS cord-028721-x6f26ahr 622 3 are be VBP cord-028721-x6f26ahr 622 4 poorly poorly RB cord-028721-x6f26ahr 622 5 developed develop VBN cord-028721-x6f26ahr 622 6 in in IN cord-028721-x6f26ahr 622 7 the the DT cord-028721-x6f26ahr 622 8 testis testis NN cord-028721-x6f26ahr 622 9 and and CC cord-028721-x6f26ahr 622 10 limited limit VBN cord-028721-x6f26ahr 622 11 to to IN cord-028721-x6f26ahr 622 12 the the DT cord-028721-x6f26ahr 622 13 tunica tunica NNP cord-028721-x6f26ahr 622 14 vasculosa vasculosa NNP cord-028721-x6f26ahr 622 15 and and CC cord-028721-x6f26ahr 622 16 interlobular interlobular NNP cord-028721-x6f26ahr 622 17 septa septa NNP cord-028721-x6f26ahr 622 18 , , , cord-028721-x6f26ahr 622 19 231 231 CD cord-028721-x6f26ahr 622 20 where where WRB cord-028721-x6f26ahr 622 21 they -PRON- PRP cord-028721-x6f26ahr 622 22 accompany accompany VBP cord-028721-x6f26ahr 622 23 arterioles arteriole NNS cord-028721-x6f26ahr 622 24 and and CC cord-028721-x6f26ahr 622 25 venules venule NNS cord-028721-x6f26ahr 622 26 . . . cord-028721-x6f26ahr 623 1 Prelymphatic prelymphatic JJ cord-028721-x6f26ahr 623 2 vessels vessel NNS cord-028721-x6f26ahr 623 3 have have VBP cord-028721-x6f26ahr 623 4 been be VBN cord-028721-x6f26ahr 623 5 reported report VBN cord-028721-x6f26ahr 623 6 in in IN cord-028721-x6f26ahr 623 7 the the DT cord-028721-x6f26ahr 623 8 interstitium interstitium NN cord-028721-x6f26ahr 623 9 and and CC cord-028721-x6f26ahr 623 10 probably probably RB cord-028721-x6f26ahr 623 11 drain drain VB cord-028721-x6f26ahr 623 12 interstitial interstitial JJ cord-028721-x6f26ahr 623 13 fl fl NNP cord-028721-x6f26ahr 623 14 uid uid NN cord-028721-x6f26ahr 623 15 into into IN cord-028721-x6f26ahr 623 16 the the DT cord-028721-x6f26ahr 623 17 true true JJ cord-028721-x6f26ahr 623 18 interlobular interlobular JJ cord-028721-x6f26ahr 623 19 lymphatic lymphatic JJ cord-028721-x6f26ahr 623 20 vessels vessel NNS cord-028721-x6f26ahr 623 21 . . . cord-028721-x6f26ahr 624 1 Efferent Efferent NNP cord-028721-x6f26ahr 624 2 innervation innervation NN cord-028721-x6f26ahr 624 3 of of IN cord-028721-x6f26ahr 624 4 the the DT cord-028721-x6f26ahr 624 5 testis testis NN cord-028721-x6f26ahr 624 6 is be VBZ cord-028721-x6f26ahr 624 7 mainly mainly RB cord-028721-x6f26ahr 624 8 supplied supply VBN cord-028721-x6f26ahr 624 9 by by IN cord-028721-x6f26ahr 624 10 neurons neuron NNS cord-028721-x6f26ahr 624 11 of of IN cord-028721-x6f26ahr 624 12 the the DT cord-028721-x6f26ahr 624 13 pelvic pelvic JJ cord-028721-x6f26ahr 624 14 ganglia ganglion NNS cord-028721-x6f26ahr 624 15 , , , cord-028721-x6f26ahr 624 16 where where WRB cord-028721-x6f26ahr 624 17 contralateral contralateral JJ cord-028721-x6f26ahr 624 18 and and CC cord-028721-x6f26ahr 624 19 bilateral bilateral JJ cord-028721-x6f26ahr 624 20 neural neural JJ cord-028721-x6f26ahr 624 21 connections connection NNS cord-028721-x6f26ahr 624 22 occur occur VBP cord-028721-x6f26ahr 624 23 . . . cord-028721-x6f26ahr 625 1 Postganglionic postganglionic JJ cord-028721-x6f26ahr 625 2 nerve nerve NN cord-028721-x6f26ahr 625 3 fi fi NN cord-028721-x6f26ahr 625 4 bers ber NNS cord-028721-x6f26ahr 625 5 enter enter VBP cord-028721-x6f26ahr 625 6 the the DT cord-028721-x6f26ahr 625 7 testis testis NN cord-028721-x6f26ahr 625 8 via via IN cord-028721-x6f26ahr 625 9 the the DT cord-028721-x6f26ahr 625 10 pelvic pelvic JJ cord-028721-x6f26ahr 625 11 nerves nerve NNS cord-028721-x6f26ahr 625 12 , , , cord-028721-x6f26ahr 625 13 extend extend VB cord-028721-x6f26ahr 625 14 throughout throughout IN cord-028721-x6f26ahr 625 15 the the DT cord-028721-x6f26ahr 625 16 tunica tunica NNP cord-028721-x6f26ahr 625 17 vasculosa vasculosa NNP cord-028721-x6f26ahr 625 18 , , , cord-028721-x6f26ahr 625 19 and and CC cord-028721-x6f26ahr 625 20 follow follow VB cord-028721-x6f26ahr 625 21 the the DT cord-028721-x6f26ahr 625 22 interlobular interlobular NNP cord-028721-x6f26ahr 625 23 septa septa NNP cord-028721-x6f26ahr 625 24 to to TO cord-028721-x6f26ahr 625 25 reach reach VB cord-028721-x6f26ahr 625 26 the the DT cord-028721-x6f26ahr 625 27 interstitium interstitium NN cord-028721-x6f26ahr 625 28 . . . cord-028721-x6f26ahr 626 1 These these DT cord-028721-x6f26ahr 626 2 nerve nerve NN cord-028721-x6f26ahr 626 3 fi fi NN cord-028721-x6f26ahr 626 4 bers ber NNS cord-028721-x6f26ahr 626 5 end end VB cord-028721-x6f26ahr 626 6 in in IN cord-028721-x6f26ahr 626 7 the the DT cord-028721-x6f26ahr 626 8 wall wall NN cord-028721-x6f26ahr 626 9 of of IN cord-028721-x6f26ahr 626 10 arterioles arteriole NNS cord-028721-x6f26ahr 626 11 , , , cord-028721-x6f26ahr 626 12 the the DT cord-028721-x6f26ahr 626 13 wall wall NN cord-028721-x6f26ahr 626 14 of of IN cord-028721-x6f26ahr 626 15 seminiferous seminiferous JJ cord-028721-x6f26ahr 626 16 tubules tubule NNS cord-028721-x6f26ahr 626 17 , , , cord-028721-x6f26ahr 626 18 and and CC cord-028721-x6f26ahr 626 19 the the DT cord-028721-x6f26ahr 626 20 Leydig Leydig NNP cord-028721-x6f26ahr 626 21 cells cell NNS cord-028721-x6f26ahr 626 22 . . . cord-028721-x6f26ahr 627 1 232 232 CD cord-028721-x6f26ahr 627 2 Adrenergic Adrenergic NNP cord-028721-x6f26ahr 627 3 nerve nerve NN cord-028721-x6f26ahr 627 4 fi fi NN cord-028721-x6f26ahr 627 5 bers ber NNS cord-028721-x6f26ahr 627 6 innervate innervate VB cord-028721-x6f26ahr 627 7 the the DT cord-028721-x6f26ahr 627 8 tunica tunica NNP cord-028721-x6f26ahr 627 9 albuginea albuginea NNP cord-028721-x6f26ahr 627 10 and and CC cord-028721-x6f26ahr 627 11 the the DT cord-028721-x6f26ahr 627 12 blood blood NN cord-028721-x6f26ahr 627 13 vessels vessel NNS cord-028721-x6f26ahr 627 14 of of IN cord-028721-x6f26ahr 627 15 the the DT cord-028721-x6f26ahr 627 16 tunica tunica NNP cord-028721-x6f26ahr 627 17 vasculosa vasculosa NNP cord-028721-x6f26ahr 627 18 . . . cord-028721-x6f26ahr 628 1 233 233 CD cord-028721-x6f26ahr 628 2 Peptidergic Peptidergic NNP cord-028721-x6f26ahr 628 3 nerve nerve NN cord-028721-x6f26ahr 628 4 endings ending NNS cord-028721-x6f26ahr 628 5 are be VBP cord-028721-x6f26ahr 628 6 uncommon uncommon JJ cord-028721-x6f26ahr 628 7 . . . cord-028721-x6f26ahr 629 1 Afferent afferent JJ cord-028721-x6f26ahr 629 2 nerve nerve NN cord-028721-x6f26ahr 629 3 endings ending NNS cord-028721-x6f26ahr 629 4 form form VBP cord-028721-x6f26ahr 629 5 corpuscles corpuscle NNS cord-028721-x6f26ahr 629 6 similar similar JJ cord-028721-x6f26ahr 629 7 to to IN cord-028721-x6f26ahr 629 8 those those DT cord-028721-x6f26ahr 629 9 of of IN cord-028721-x6f26ahr 629 10 Meissner Meissner NNP cord-028721-x6f26ahr 629 11 and and CC cord-028721-x6f26ahr 629 12 Pacini Pacini NNP cord-028721-x6f26ahr 629 13 in in IN cord-028721-x6f26ahr 629 14 the the DT cord-028721-x6f26ahr 629 15 tunica tunica NNP cord-028721-x6f26ahr 629 16 albuginea albuginea NNP cord-028721-x6f26ahr 629 17 . . . cord-028721-x6f26ahr 630 1 The the DT cord-028721-x6f26ahr 630 2 rete rete NN cord-028721-x6f26ahr 630 3 testis testis NN cord-028721-x6f26ahr 630 4 is be VBZ cord-028721-x6f26ahr 630 5 a a DT cord-028721-x6f26ahr 630 6 network network NN cord-028721-x6f26ahr 630 7 of of IN cord-028721-x6f26ahr 630 8 channels channel NNS cord-028721-x6f26ahr 630 9 and and CC cord-028721-x6f26ahr 630 10 cavities cavity NNS cord-028721-x6f26ahr 630 11 that that WDT cord-028721-x6f26ahr 630 12 connects connect VBZ cord-028721-x6f26ahr 630 13 the the DT cord-028721-x6f26ahr 630 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 630 15 tubules tubule NNS cord-028721-x6f26ahr 630 16 with with IN cord-028721-x6f26ahr 630 17 the the DT cord-028721-x6f26ahr 630 18 ductuli ductuli NNP cord-028721-x6f26ahr 630 19 efferentes efferentes NNP cord-028721-x6f26ahr 630 20 . . . cord-028721-x6f26ahr 631 1 Differences difference NNS cord-028721-x6f26ahr 631 2 in in IN cord-028721-x6f26ahr 631 3 the the DT cord-028721-x6f26ahr 631 4 confi confi NN cord-028721-x6f26ahr 631 5 guration guration NN cord-028721-x6f26ahr 631 6 and and CC cord-028721-x6f26ahr 631 7 size size NN cord-028721-x6f26ahr 631 8 of of IN cord-028721-x6f26ahr 631 9 channels channel NNS cord-028721-x6f26ahr 631 10 and and CC cord-028721-x6f26ahr 631 11 cavities cavity NNS cord-028721-x6f26ahr 631 12 distinguish distinguish VBP cord-028721-x6f26ahr 631 13 three three CD cord-028721-x6f26ahr 631 14 portions portion NNS cord-028721-x6f26ahr 631 15 of of IN cord-028721-x6f26ahr 631 16 the the DT cord-028721-x6f26ahr 631 17 rete rete NNP cord-028721-x6f26ahr 631 18 testis testis NN cord-028721-x6f26ahr 631 19 : : : cord-028721-x6f26ahr 631 20 septal septal JJ cord-028721-x6f26ahr 631 21 ( ( -LRB- cord-028721-x6f26ahr 631 22 intralobular intralobular NNP cord-028721-x6f26ahr 631 23 ) ) -RRB- cord-028721-x6f26ahr 631 24 , , , cord-028721-x6f26ahr 631 25 composed compose VBN cord-028721-x6f26ahr 631 26 of of IN cord-028721-x6f26ahr 631 27 the the DT cord-028721-x6f26ahr 631 28 tubuli tubuli NNP cord-028721-x6f26ahr 631 29 recti recti NNP cord-028721-x6f26ahr 631 30 ; ; : cord-028721-x6f26ahr 631 31 mediastinal mediastinal JJ cord-028721-x6f26ahr 631 32 , , , cord-028721-x6f26ahr 631 33 composed compose VBN cord-028721-x6f26ahr 631 34 of of IN cord-028721-x6f26ahr 631 35 a a DT cord-028721-x6f26ahr 631 36 network network NN cord-028721-x6f26ahr 631 37 of of IN cord-028721-x6f26ahr 631 38 interconnected interconnected JJ cord-028721-x6f26ahr 631 39 channels channel NNS cord-028721-x6f26ahr 631 40 ; ; : cord-028721-x6f26ahr 631 41 and and CC cord-028721-x6f26ahr 631 42 extratesticular extratesticular NNP cord-028721-x6f26ahr 631 43 , , , cord-028721-x6f26ahr 631 44 composed compose VBN cord-028721-x6f26ahr 631 45 of of IN cord-028721-x6f26ahr 631 46 dilated dilated JJ cord-028721-x6f26ahr 631 47 cavities cavity NNS cord-028721-x6f26ahr 631 48 ( ( -LRB- cord-028721-x6f26ahr 631 49 up up IN cord-028721-x6f26ahr 631 50 to to TO cord-028721-x6f26ahr 631 51 3 3 CD cord-028721-x6f26ahr 631 52 mm mm NN cord-028721-x6f26ahr 631 53 in in IN cord-028721-x6f26ahr 631 54 diameter diameter NN cord-028721-x6f26ahr 631 55 ) ) -RRB- cord-028721-x6f26ahr 631 56 termed term VBD cord-028721-x6f26ahr 631 57 the the DT cord-028721-x6f26ahr 631 58 bullae bulla NNS cord-028721-x6f26ahr 631 59 retis retis NN cord-028721-x6f26ahr 631 60 . . . cord-028721-x6f26ahr 632 1 The the DT cord-028721-x6f26ahr 632 2 tubuli tubuli NNP cord-028721-x6f26ahr 632 3 recti recti NNP cord-028721-x6f26ahr 632 4 are be VBP cord-028721-x6f26ahr 632 5 short short JJ cord-028721-x6f26ahr 632 6 tubules tubule NNS cord-028721-x6f26ahr 632 7 ( ( -LRB- cord-028721-x6f26ahr 632 8 0.5 0.5 CD cord-028721-x6f26ahr 632 9 - - SYM cord-028721-x6f26ahr 632 10 1 1 CD cord-028721-x6f26ahr 632 11 mm mm NN cord-028721-x6f26ahr 632 12 long long RB cord-028721-x6f26ahr 632 13 ) ) -RRB- cord-028721-x6f26ahr 632 14 that that WDT cord-028721-x6f26ahr 632 15 connect connect VBP cord-028721-x6f26ahr 632 16 the the DT cord-028721-x6f26ahr 632 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 632 18 tubules tubule NNS cord-028721-x6f26ahr 632 19 to to IN cord-028721-x6f26ahr 632 20 the the DT cord-028721-x6f26ahr 632 21 mediastinal mediastinal JJ cord-028721-x6f26ahr 632 22 rete rete NN cord-028721-x6f26ahr 632 23 , , , cord-028721-x6f26ahr 632 24 although although IN cord-028721-x6f26ahr 632 25 some some DT cord-028721-x6f26ahr 632 26 seminiferous seminiferous JJ cord-028721-x6f26ahr 632 27 tubules tubule NNS cord-028721-x6f26ahr 632 28 may may MD cord-028721-x6f26ahr 632 29 connect connect VB cord-028721-x6f26ahr 632 30 directly directly RB cord-028721-x6f26ahr 632 31 to to IN cord-028721-x6f26ahr 632 32 the the DT cord-028721-x6f26ahr 632 33 mediastinal mediastinal JJ cord-028721-x6f26ahr 632 34 rete rete NN cord-028721-x6f26ahr 632 35 , , , cord-028721-x6f26ahr 632 36 principally principally RB cord-028721-x6f26ahr 632 37 those those DT cord-028721-x6f26ahr 632 38 in in IN cord-028721-x6f26ahr 632 39 the the DT cord-028721-x6f26ahr 632 40 central central JJ cord-028721-x6f26ahr 632 41 region region NN cord-028721-x6f26ahr 632 42 of of IN cord-028721-x6f26ahr 632 43 the the DT cord-028721-x6f26ahr 632 44 testis testis NN cord-028721-x6f26ahr 632 45 . . . cord-028721-x6f26ahr 633 1 The the DT cord-028721-x6f26ahr 633 2 tubuli tubuli NNP cord-028721-x6f26ahr 633 3 recti recti NNP cord-028721-x6f26ahr 633 4 are be VBP cord-028721-x6f26ahr 633 5 lined line VBN cord-028721-x6f26ahr 633 6 by by IN cord-028721-x6f26ahr 633 7 cuboidal cuboidal JJ cord-028721-x6f26ahr 633 8 epithelium epithelium NN cord-028721-x6f26ahr 633 9 . . . cord-028721-x6f26ahr 634 1 There there EX cord-028721-x6f26ahr 634 2 are be VBP cord-028721-x6f26ahr 634 3 approximately approximately RB cord-028721-x6f26ahr 634 4 1500 1500 CD cord-028721-x6f26ahr 634 5 tubuli tubuli NNP cord-028721-x6f26ahr 634 6 recti recti NNP cord-028721-x6f26ahr 634 7 ( ( -LRB- cord-028721-x6f26ahr 634 8 or or CC cord-028721-x6f26ahr 634 9 their -PRON- PRP$ cord-028721-x6f26ahr 634 10 analogous analogous JJ cord-028721-x6f26ahr 634 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 634 12 tubule tubule NN cord-028721-x6f26ahr 634 13 segments segment NNS cord-028721-x6f26ahr 634 14 ) ) -RRB- cord-028721-x6f26ahr 634 15 . . . cord-028721-x6f26ahr 635 1 The the DT cord-028721-x6f26ahr 635 2 tubuli tubuli NNP cord-028721-x6f26ahr 635 3 recti recti NN cord-028721-x6f26ahr 635 4 in in IN cord-028721-x6f26ahr 635 5 the the DT cord-028721-x6f26ahr 635 6 cranial cranial JJ cord-028721-x6f26ahr 635 7 , , , cord-028721-x6f26ahr 635 8 central central JJ cord-028721-x6f26ahr 635 9 , , , cord-028721-x6f26ahr 635 10 and and CC cord-028721-x6f26ahr 635 11 anterior anterior JJ cord-028721-x6f26ahr 635 12 testis testis NN cord-028721-x6f26ahr 635 13 are be VBP cord-028721-x6f26ahr 635 14 perpendicular perpendicular JJ cord-028721-x6f26ahr 635 15 to to IN cord-028721-x6f26ahr 635 16 the the DT cord-028721-x6f26ahr 635 17 mediastinal mediastinal JJ cord-028721-x6f26ahr 635 18 rete rete FW cord-028721-x6f26ahr 635 19 testis testis NN cord-028721-x6f26ahr 635 20 channel channel NN cord-028721-x6f26ahr 635 21 into into IN cord-028721-x6f26ahr 635 22 which which WDT cord-028721-x6f26ahr 635 23 they -PRON- PRP cord-028721-x6f26ahr 635 24 drain drain VBP cord-028721-x6f26ahr 635 25 , , , cord-028721-x6f26ahr 635 26 and and CC cord-028721-x6f26ahr 635 27 those those DT cord-028721-x6f26ahr 635 28 in in IN cord-028721-x6f26ahr 635 29 the the DT cord-028721-x6f26ahr 635 30 caudal caudal JJ cord-028721-x6f26ahr 635 31 testicular testicular JJ cord-028721-x6f26ahr 635 32 region region NN cord-028721-x6f26ahr 635 33 are be VBP cord-028721-x6f26ahr 635 34 parallel parallel JJ cord-028721-x6f26ahr 635 35 to to IN cord-028721-x6f26ahr 635 36 their -PRON- PRP$ cord-028721-x6f26ahr 635 37 respective respective JJ cord-028721-x6f26ahr 635 38 channels channel NNS cord-028721-x6f26ahr 635 39 . . . cord-028721-x6f26ahr 636 1 The the DT cord-028721-x6f26ahr 636 2 transitional transitional JJ cord-028721-x6f26ahr 636 3 segments segment NNS cord-028721-x6f26ahr 636 4 between between IN cord-028721-x6f26ahr 636 5 the the DT cord-028721-x6f26ahr 636 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 636 7 tubules tubule NNS cord-028721-x6f26ahr 636 8 and and CC cord-028721-x6f26ahr 636 9 the the DT cord-028721-x6f26ahr 636 10 tubuli tubuli NNP cord-028721-x6f26ahr 636 11 recti recti NNP cord-028721-x6f26ahr 636 12 are be VBP cord-028721-x6f26ahr 636 13 formed form VBN cord-028721-x6f26ahr 636 14 by by IN cord-028721-x6f26ahr 636 15 modifi modifi NNPS cord-028721-x6f26ahr 636 16 ed ed NNP cord-028721-x6f26ahr 636 17 Sertoli Sertoli NNP cord-028721-x6f26ahr 636 18 cells cell NNS cord-028721-x6f26ahr 636 19 . . . cord-028721-x6f26ahr 637 1 234 234 CD cord-028721-x6f26ahr 638 1 The the DT cord-028721-x6f26ahr 638 2 epithelium epithelium NN cord-028721-x6f26ahr 638 3 of of IN cord-028721-x6f26ahr 638 4 the the DT cord-028721-x6f26ahr 638 5 mediastinal mediastinal JJ cord-028721-x6f26ahr 638 6 rete rete NNP cord-028721-x6f26ahr 638 7 testis testis NN cord-028721-x6f26ahr 638 8 consists consist VBZ cord-028721-x6f26ahr 638 9 of of IN cord-028721-x6f26ahr 638 10 fl fl NNP cord-028721-x6f26ahr 638 11 attened attene VBN cord-028721-x6f26ahr 638 12 cells cell NNS cord-028721-x6f26ahr 638 13 interspersed intersperse VBN cord-028721-x6f26ahr 638 14 with with IN cord-028721-x6f26ahr 638 15 small small JJ cord-028721-x6f26ahr 638 16 areas area NNS cord-028721-x6f26ahr 638 17 of of IN cord-028721-x6f26ahr 638 18 columnar columnar JJ cord-028721-x6f26ahr 638 19 cells cell NNS cord-028721-x6f26ahr 638 20 . . . cord-028721-x6f26ahr 639 1 Both both DT cord-028721-x6f26ahr 639 2 cell cell NN cord-028721-x6f26ahr 639 3 types type NNS cord-028721-x6f26ahr 639 4 have have VBP cord-028721-x6f26ahr 639 5 single single JJ cord-028721-x6f26ahr 639 6 centrally centrally RB cord-028721-x6f26ahr 639 7 located locate VBN cord-028721-x6f26ahr 639 8 cilia cilium NNS cord-028721-x6f26ahr 639 9 and and CC cord-028721-x6f26ahr 639 10 numerous numerous JJ cord-028721-x6f26ahr 639 11 microvilli microvilli NN cord-028721-x6f26ahr 639 12 on on IN cord-028721-x6f26ahr 639 13 their -PRON- PRP$ cord-028721-x6f26ahr 639 14 free free JJ cord-028721-x6f26ahr 639 15 surfaces surface NNS cord-028721-x6f26ahr 639 16 , , , cord-028721-x6f26ahr 639 17 and and CC cord-028721-x6f26ahr 639 18 contain contain VBP cord-028721-x6f26ahr 639 19 keratin keratin NN cord-028721-x6f26ahr 639 20 and and CC cord-028721-x6f26ahr 639 21 vimentin vimentin NN cord-028721-x6f26ahr 639 22 fi fi NN cord-028721-x6f26ahr 639 23 laments lament NNS cord-028721-x6f26ahr 639 24 . . . cord-028721-x6f26ahr 640 1 235 235 CD cord-028721-x6f26ahr 641 1 There there EX cord-028721-x6f26ahr 641 2 are be VBP cord-028721-x6f26ahr 641 3 interdigitations interdigitation NNS cord-028721-x6f26ahr 641 4 between between IN cord-028721-x6f26ahr 641 5 adjacent adjacent JJ cord-028721-x6f26ahr 641 6 cells cell NNS cord-028721-x6f26ahr 641 7 . . . cord-028721-x6f26ahr 642 1 The the DT cord-028721-x6f26ahr 642 2 epithelium epithelium NN cord-028721-x6f26ahr 642 3 rests rest VBZ cord-028721-x6f26ahr 642 4 on on IN cord-028721-x6f26ahr 642 5 a a DT cord-028721-x6f26ahr 642 6 basal basal NN cord-028721-x6f26ahr 642 7 lamina lamina NN cord-028721-x6f26ahr 642 8 , , , cord-028721-x6f26ahr 642 9 surrounded surround VBN cord-028721-x6f26ahr 642 10 by by IN cord-028721-x6f26ahr 642 11 a a DT cord-028721-x6f26ahr 642 12 layer layer NN cord-028721-x6f26ahr 642 13 of of IN cord-028721-x6f26ahr 642 14 myofi myofi NNP cord-028721-x6f26ahr 642 15 broblasts broblasts NNP cord-028721-x6f26ahr 642 16 and and CC cord-028721-x6f26ahr 642 17 a a DT cord-028721-x6f26ahr 642 18 more more RBR cord-028721-x6f26ahr 642 19 peripheral peripheral JJ cord-028721-x6f26ahr 642 20 layer layer NN cord-028721-x6f26ahr 642 21 of of IN cord-028721-x6f26ahr 642 22 fi fi NN cord-028721-x6f26ahr 642 23 broblasts broblast NNS cord-028721-x6f26ahr 642 24 and and CC cord-028721-x6f26ahr 642 25 collagen collagen NN cord-028721-x6f26ahr 642 26 and and CC cord-028721-x6f26ahr 642 27 elastic elastic JJ cord-028721-x6f26ahr 642 28 fi fi NN cord-028721-x6f26ahr 642 29 bers ber NNS cord-028721-x6f26ahr 642 30 . . . cord-028721-x6f26ahr 643 1 The the DT cord-028721-x6f26ahr 643 2 rete rete NN cord-028721-x6f26ahr 643 3 channels channel NNS cord-028721-x6f26ahr 643 4 and and CC cord-028721-x6f26ahr 643 5 cavities cavity NNS cord-028721-x6f26ahr 643 6 are be VBP cord-028721-x6f26ahr 643 7 traversed traverse VBN cord-028721-x6f26ahr 643 8 by by IN cord-028721-x6f26ahr 643 9 the the DT cord-028721-x6f26ahr 643 10 chordae chordae NNP cord-028721-x6f26ahr 643 11 rete rete NN cord-028721-x6f26ahr 643 12 , , , cord-028721-x6f26ahr 643 13 columns column NNS cord-028721-x6f26ahr 643 14 from from IN cord-028721-x6f26ahr 643 15 15 15 CD cord-028721-x6f26ahr 643 16 µm µm CD cord-028721-x6f26ahr 643 17 to to IN cord-028721-x6f26ahr 643 18 100 100 CD cord-028721-x6f26ahr 643 19 µm µm NNS cord-028721-x6f26ahr 643 20 long long JJ cord-028721-x6f26ahr 643 21 and and CC cord-028721-x6f26ahr 643 22 from from IN cord-028721-x6f26ahr 643 23 5 5 CD cord-028721-x6f26ahr 643 24 µm µm CD cord-028721-x6f26ahr 643 25 to to IN cord-028721-x6f26ahr 643 26 40 40 CD cord-028721-x6f26ahr 643 27 µm µm CD cord-028721-x6f26ahr 643 28 wide wide JJ cord-028721-x6f26ahr 643 29 , , , cord-028721-x6f26ahr 643 30 arranged arrange VBD cord-028721-x6f26ahr 643 31 obliquely obliquely RB cord-028721-x6f26ahr 643 32 to to IN cord-028721-x6f26ahr 643 33 the the DT cord-028721-x6f26ahr 643 34 long long JJ cord-028721-x6f26ahr 643 35 axis axis NN cord-028721-x6f26ahr 643 36 of of IN cord-028721-x6f26ahr 643 37 the the DT cord-028721-x6f26ahr 643 38 cavity cavity NN cord-028721-x6f26ahr 643 39 . . . cord-028721-x6f26ahr 644 1 The the DT cord-028721-x6f26ahr 644 2 chordae chordae NN cord-028721-x6f26ahr 644 3 consist consist VBP cord-028721-x6f26ahr 644 4 of of IN cord-028721-x6f26ahr 644 5 fi fi NNP cord-028721-x6f26ahr 644 6 brous brous JJ cord-028721-x6f26ahr 644 7 connective connective JJ cord-028721-x6f26ahr 644 8 tissue tissue NN cord-028721-x6f26ahr 644 9 with with IN cord-028721-x6f26ahr 644 10 fi fi NNP cord-028721-x6f26ahr 644 11 broblasts broblast NNS cord-028721-x6f26ahr 644 12 and and CC cord-028721-x6f26ahr 644 13 are be VBP cord-028721-x6f26ahr 644 14 covered cover VBN cord-028721-x6f26ahr 644 15 by by IN cord-028721-x6f26ahr 644 16 fl fl NNP cord-028721-x6f26ahr 644 17 attened attene VBN cord-028721-x6f26ahr 644 18 epithelium epithelium NN cord-028721-x6f26ahr 644 19 ; ; : cord-028721-x6f26ahr 644 20 the the DT cord-028721-x6f26ahr 644 21 widest wide JJS cord-028721-x6f26ahr 644 22 contain contain VBP cord-028721-x6f26ahr 644 23 capillaries capillary NNS cord-028721-x6f26ahr 644 24 . . . cord-028721-x6f26ahr 645 1 The the DT cord-028721-x6f26ahr 645 2 rete rete NN cord-028721-x6f26ahr 645 3 testis testis NN cord-028721-x6f26ahr 645 4 probably probably RB cord-028721-x6f26ahr 645 5 has have VBZ cord-028721-x6f26ahr 645 6 the the DT cord-028721-x6f26ahr 645 7 following follow VBG cord-028721-x6f26ahr 645 8 functions function NNS cord-028721-x6f26ahr 645 9 : : : cord-028721-x6f26ahr 645 10 damping damp VBG cord-028721-x6f26ahr 645 11 differences difference NNS cord-028721-x6f26ahr 645 12 in in IN cord-028721-x6f26ahr 645 13 pressure pressure NN cord-028721-x6f26ahr 645 14 between between IN cord-028721-x6f26ahr 645 15 the the DT cord-028721-x6f26ahr 645 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 645 17 tubules tubule NNS cord-028721-x6f26ahr 645 18 and and CC cord-028721-x6f26ahr 645 19 ductuli ductuli NNP cord-028721-x6f26ahr 645 20 efferentes efferentes NNPS cord-028721-x6f26ahr 645 21 ; ; : cord-028721-x6f26ahr 645 22 reabsorption reabsorption NN cord-028721-x6f26ahr 645 23 of of IN cord-028721-x6f26ahr 645 24 protein protein NN cord-028721-x6f26ahr 645 25 and and CC cord-028721-x6f26ahr 645 26 potassium potassium NN cord-028721-x6f26ahr 645 27 from from IN cord-028721-x6f26ahr 645 28 tubular tubular JJ cord-028721-x6f26ahr 645 29 fl fl NNP cord-028721-x6f26ahr 645 30 uid uid NN cord-028721-x6f26ahr 645 31 ; ; : cord-028721-x6f26ahr 645 32 and and CC cord-028721-x6f26ahr 645 33 , , , cord-028721-x6f26ahr 645 34 occasionally occasionally RB cord-028721-x6f26ahr 645 35 , , , cord-028721-x6f26ahr 645 36 phagocytosis phagocytosis NN cord-028721-x6f26ahr 645 37 of of IN cord-028721-x6f26ahr 645 38 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 645 39 . . . cord-028721-x6f26ahr 646 1 Anorchidism Anorchidism NNP cord-028721-x6f26ahr 646 2 refers refer VBZ cord-028721-x6f26ahr 646 3 to to IN cord-028721-x6f26ahr 646 4 the the DT cord-028721-x6f26ahr 646 5 absence absence NN cord-028721-x6f26ahr 646 6 of of IN cord-028721-x6f26ahr 646 7 one one CD cord-028721-x6f26ahr 646 8 ( ( -LRB- cord-028721-x6f26ahr 646 9 monorchidism monorchidism NN cord-028721-x6f26ahr 646 10 ) ) -RRB- cord-028721-x6f26ahr 646 11 or or CC cord-028721-x6f26ahr 646 12 both both DT cord-028721-x6f26ahr 646 13 testes testis NNS cord-028721-x6f26ahr 646 14 ( ( -LRB- cord-028721-x6f26ahr 646 15 testicular testicular JJ cord-028721-x6f26ahr 646 16 regression regression NN cord-028721-x6f26ahr 646 17 syndrome syndrome NN cord-028721-x6f26ahr 646 18 ) ) -RRB- cord-028721-x6f26ahr 646 19 . . . cord-028721-x6f26ahr 647 1 Monorchidism Monorchidism NNP cord-028721-x6f26ahr 647 2 is be VBZ cord-028721-x6f26ahr 647 3 estimated estimate VBN cord-028721-x6f26ahr 647 4 to to TO cord-028721-x6f26ahr 647 5 occur occur VB cord-028721-x6f26ahr 647 6 in in IN cord-028721-x6f26ahr 647 7 about about RB cord-028721-x6f26ahr 647 8 4.5 4.5 CD cord-028721-x6f26ahr 647 9 % % NN cord-028721-x6f26ahr 647 10 of of IN cord-028721-x6f26ahr 647 11 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 647 12 testes testis NNS cord-028721-x6f26ahr 647 13 , , , cord-028721-x6f26ahr 647 14 236 236 CD cord-028721-x6f26ahr 647 15 40 40 CD cord-028721-x6f26ahr 647 16 % % NN cord-028721-x6f26ahr 647 17 of of IN cord-028721-x6f26ahr 647 18 the the DT cord-028721-x6f26ahr 647 19 testes testis NNS cord-028721-x6f26ahr 647 20 that that WDT cord-028721-x6f26ahr 647 21 are be VBP cord-028721-x6f26ahr 647 22 impalpable impalpable JJ cord-028721-x6f26ahr 647 23 in in IN cord-028721-x6f26ahr 647 24 physical physical JJ cord-028721-x6f26ahr 647 25 examination examination NN cord-028721-x6f26ahr 647 26 , , , cord-028721-x6f26ahr 647 27 237 237 CD cord-028721-x6f26ahr 647 28 or or CC cord-028721-x6f26ahr 647 29 1 1 CD cord-028721-x6f26ahr 647 30 in in IN cord-028721-x6f26ahr 647 31 5000 5000 CD cord-028721-x6f26ahr 647 32 males male NNS cord-028721-x6f26ahr 647 33 . . . cord-028721-x6f26ahr 648 1 Bilateral bilateral JJ cord-028721-x6f26ahr 648 2 anorchidism anorchidism NN cord-028721-x6f26ahr 648 3 occurs occur VBZ cord-028721-x6f26ahr 648 4 in in IN cord-028721-x6f26ahr 648 5 approximately approximately RB cord-028721-x6f26ahr 648 6 1 1 CD cord-028721-x6f26ahr 648 7 in in IN cord-028721-x6f26ahr 648 8 20 20 CD cord-028721-x6f26ahr 648 9 000 000 CD cord-028721-x6f26ahr 648 10 males male NNS cord-028721-x6f26ahr 648 11 . . . cord-028721-x6f26ahr 649 1 238 238 CD cord-028721-x6f26ahr 649 2 Monorchidism Monorchidism NNP cord-028721-x6f26ahr 650 1 The the DT cord-028721-x6f26ahr 650 2 hormonal hormonal JJ cord-028721-x6f26ahr 650 3 pattern pattern NN cord-028721-x6f26ahr 650 4 in in IN cord-028721-x6f26ahr 650 5 prepubertal prepubertal JJ cord-028721-x6f26ahr 650 6 patients patient NNS cord-028721-x6f26ahr 650 7 with with IN cord-028721-x6f26ahr 650 8 monorchidism monorchidism NN cord-028721-x6f26ahr 650 9 does do VBZ cord-028721-x6f26ahr 650 10 not not RB cord-028721-x6f26ahr 650 11 differ differ VB cord-028721-x6f26ahr 650 12 from from IN cord-028721-x6f26ahr 650 13 that that DT cord-028721-x6f26ahr 650 14 of of IN cord-028721-x6f26ahr 650 15 normal normal JJ cord-028721-x6f26ahr 650 16 children child NNS cord-028721-x6f26ahr 650 17 , , , cord-028721-x6f26ahr 650 18 whereas whereas IN cord-028721-x6f26ahr 650 19 children child NNS cord-028721-x6f26ahr 650 20 lacking lack VBG cord-028721-x6f26ahr 650 21 both both DT cord-028721-x6f26ahr 650 22 testes testis NNS cord-028721-x6f26ahr 650 23 have have VBP cord-028721-x6f26ahr 650 24 elevated elevate VBN cord-028721-x6f26ahr 650 25 levels level NNS cord-028721-x6f26ahr 650 26 of of IN cord-028721-x6f26ahr 650 27 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 650 28 and and CC cord-028721-x6f26ahr 650 29 fail fail VB cord-028721-x6f26ahr 650 30 to to TO cord-028721-x6f26ahr 650 31 respond respond VB cord-028721-x6f26ahr 650 32 to to IN cord-028721-x6f26ahr 650 33 stimulation stimulation NN cord-028721-x6f26ahr 650 34 with with IN cord-028721-x6f26ahr 650 35 hCG hCG NNP cord-028721-x6f26ahr 650 36 . . . cord-028721-x6f26ahr 651 1 [ [ -LRB- cord-028721-x6f26ahr 651 2 238 238 CD cord-028721-x6f26ahr 651 3 ] ] -RRB- cord-028721-x6f26ahr 651 4 [ [ -LRB- cord-028721-x6f26ahr 651 5 239 239 CD cord-028721-x6f26ahr 651 6 ] ] -RRB- cord-028721-x6f26ahr 651 7 [ [ -LRB- cord-028721-x6f26ahr 651 8 240 240 CD cord-028721-x6f26ahr 651 9 ] ] -RRB- cord-028721-x6f26ahr 652 1 Although although IN cord-028721-x6f26ahr 652 2 the the DT cord-028721-x6f26ahr 652 3 hCG hCG NNP cord-028721-x6f26ahr 652 4 stimulation stimulation NN cord-028721-x6f26ahr 652 5 test test NN cord-028721-x6f26ahr 652 6 is be VBZ cord-028721-x6f26ahr 652 7 often often RB cord-028721-x6f26ahr 652 8 positive positive JJ cord-028721-x6f26ahr 652 9 in in IN cord-028721-x6f26ahr 652 10 children child NNS cord-028721-x6f26ahr 652 11 with with IN cord-028721-x6f26ahr 652 12 bilateral bilateral JJ cord-028721-x6f26ahr 652 13 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 652 14 , , , cord-028721-x6f26ahr 652 15 it -PRON- PRP cord-028721-x6f26ahr 652 16 is be VBZ cord-028721-x6f26ahr 652 17 negative negative JJ cord-028721-x6f26ahr 652 18 in in IN cord-028721-x6f26ahr 652 19 some some DT cord-028721-x6f26ahr 652 20 children child NNS cord-028721-x6f26ahr 652 21 with with IN cord-028721-x6f26ahr 652 22 bilateral bilateral JJ cord-028721-x6f26ahr 652 23 intra intra JJ cord-028721-x6f26ahr 652 24 - - JJ cord-028721-x6f26ahr 652 25 abdominal abdominal JJ cord-028721-x6f26ahr 652 26 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 652 27 and and CC cord-028721-x6f26ahr 652 28 this this DT cord-028721-x6f26ahr 652 29 further further RB cord-028721-x6f26ahr 652 30 complicates complicate VBZ cord-028721-x6f26ahr 652 31 the the DT cord-028721-x6f26ahr 652 32 differential differential JJ cord-028721-x6f26ahr 652 33 diagnosis diagnosis NN cord-028721-x6f26ahr 652 34 between between IN cord-028721-x6f26ahr 652 35 anorchidism anorchidism NN cord-028721-x6f26ahr 652 36 and and CC cord-028721-x6f26ahr 652 37 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 652 38 . . . cord-028721-x6f26ahr 653 1 241 241 CD cord-028721-x6f26ahr 654 1 For for IN cord-028721-x6f26ahr 654 2 unknown unknown JJ cord-028721-x6f26ahr 654 3 reasons reason NNS cord-028721-x6f26ahr 654 4 , , , cord-028721-x6f26ahr 654 5 the the DT cord-028721-x6f26ahr 654 6 left left JJ cord-028721-x6f26ahr 654 7 testis testis NN cord-028721-x6f26ahr 654 8 is be VBZ cord-028721-x6f26ahr 654 9 more more RBR cord-028721-x6f26ahr 654 10 frequently frequently RB cord-028721-x6f26ahr 654 11 absent absent JJ cord-028721-x6f26ahr 654 12 ( ( -LRB- cord-028721-x6f26ahr 654 13 68.7 68.7 CD cord-028721-x6f26ahr 654 14 % % NN cord-028721-x6f26ahr 654 15 ) ) -RRB- cord-028721-x6f26ahr 654 16 than than IN cord-028721-x6f26ahr 654 17 the the DT cord-028721-x6f26ahr 654 18 right right NN cord-028721-x6f26ahr 654 19 . . . cord-028721-x6f26ahr 655 1 In in IN cord-028721-x6f26ahr 655 2 such such JJ cord-028721-x6f26ahr 655 3 cases case NNS cord-028721-x6f26ahr 655 4 the the DT cord-028721-x6f26ahr 655 5 contralateral contralateral JJ cord-028721-x6f26ahr 655 6 scrotal scrotal JJ cord-028721-x6f26ahr 655 7 testis testis NN cord-028721-x6f26ahr 655 8 undergoes undergo VBZ cord-028721-x6f26ahr 655 9 compensatory compensatory JJ cord-028721-x6f26ahr 655 10 hypertrophy hypertrophy NN cord-028721-x6f26ahr 655 11 and and CC cord-028721-x6f26ahr 655 12 its -PRON- PRP$ cord-028721-x6f26ahr 655 13 volume volume NN cord-028721-x6f26ahr 655 14 increases increase VBZ cord-028721-x6f26ahr 655 15 to to IN cord-028721-x6f26ahr 655 16 more more JJR cord-028721-x6f26ahr 655 17 than than IN cord-028721-x6f26ahr 655 18 2 2 CD cord-028721-x6f26ahr 655 19 mL. mL. NNS cord-028721-x6f26ahr 655 20 242 242 CD cord-028721-x6f26ahr 655 21 Compensatory compensatory JJ cord-028721-x6f26ahr 655 22 hypertrophy hypertrophy NN cord-028721-x6f26ahr 655 23 has have VBZ cord-028721-x6f26ahr 655 24 also also RB cord-028721-x6f26ahr 655 25 been be VBN cord-028721-x6f26ahr 655 26 reported report VBN cord-028721-x6f26ahr 655 27 in in IN cord-028721-x6f26ahr 655 28 association association NN cord-028721-x6f26ahr 655 29 with with IN cord-028721-x6f26ahr 655 30 abdominal abdominal JJ cord-028721-x6f26ahr 655 31 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 655 32 testis testis NN cord-028721-x6f26ahr 655 33 . . . cord-028721-x6f26ahr 656 1 243 243 CD cord-028721-x6f26ahr 657 1 The the DT cord-028721-x6f26ahr 657 2 absence absence NN cord-028721-x6f26ahr 657 3 of of IN cord-028721-x6f26ahr 657 4 testicular testicular JJ cord-028721-x6f26ahr 657 5 parenchyma parenchyma NNS cord-028721-x6f26ahr 657 6 should should MD cord-028721-x6f26ahr 657 7 be be VB cord-028721-x6f26ahr 657 8 confi confi NNP cord-028721-x6f26ahr 657 9 rmed rme VBN cord-028721-x6f26ahr 657 10 before before IN cord-028721-x6f26ahr 657 11 diagnosing diagnose VBG cord-028721-x6f26ahr 657 12 monorchidism monorchidism NN cord-028721-x6f26ahr 657 13 . . . cord-028721-x6f26ahr 658 1 At at IN cord-028721-x6f26ahr 658 2 exploration exploration NN cord-028721-x6f26ahr 658 3 , , , cord-028721-x6f26ahr 658 4 the the DT cord-028721-x6f26ahr 658 5 fi fi NNP cord-028721-x6f26ahr 658 6 nding nding NN cord-028721-x6f26ahr 658 7 of of IN cord-028721-x6f26ahr 658 8 a a DT cord-028721-x6f26ahr 658 9 vas vas FW cord-028721-x6f26ahr 658 10 deferens deferen NNS cord-028721-x6f26ahr 658 11 ending end VBG cord-028721-x6f26ahr 658 12 near near RB cord-028721-x6f26ahr 658 13 or or CC cord-028721-x6f26ahr 658 14 in in IN cord-028721-x6f26ahr 658 15 a a DT cord-028721-x6f26ahr 658 16 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 658 17 epididymis epididymis NN cord-028721-x6f26ahr 658 18 is be VBZ cord-028721-x6f26ahr 658 19 not not RB cord-028721-x6f26ahr 658 20 suffi suffi NNP cord-028721-x6f26ahr 658 21 cient cient NN cord-028721-x6f26ahr 658 22 for for IN cord-028721-x6f26ahr 658 23 the the DT cord-028721-x6f26ahr 658 24 diagnosis diagnosis NN cord-028721-x6f26ahr 658 25 of of IN cord-028721-x6f26ahr 658 26 monorchidism monorchidism NN cord-028721-x6f26ahr 658 27 . . . cord-028721-x6f26ahr 659 1 The the DT cord-028721-x6f26ahr 659 2 only only JJ cord-028721-x6f26ahr 659 3 acceptable acceptable JJ cord-028721-x6f26ahr 659 4 fi fi NN cord-028721-x6f26ahr 659 5 nding nding NN cord-028721-x6f26ahr 659 6 is be VBZ cord-028721-x6f26ahr 659 7 blind blind RB cord-028721-x6f26ahr 659 8 - - HYPH cord-028721-x6f26ahr 659 9 ending end VBG cord-028721-x6f26ahr 659 10 spermatic spermatic JJ cord-028721-x6f26ahr 659 11 vessels vessel NNS cord-028721-x6f26ahr 659 12 . . . cord-028721-x6f26ahr 660 1 If if IN cord-028721-x6f26ahr 660 2 inguinoscrotal inguinoscrotal JJ cord-028721-x6f26ahr 660 3 exploration exploration NN cord-028721-x6f26ahr 660 4 fails fail VBZ cord-028721-x6f26ahr 660 5 to to TO cord-028721-x6f26ahr 660 6 identify identify VB cord-028721-x6f26ahr 660 7 these these DT cord-028721-x6f26ahr 660 8 vessels vessel NNS cord-028721-x6f26ahr 660 9 , , , cord-028721-x6f26ahr 660 10 intra intra JJ cord-028721-x6f26ahr 660 11 - - JJ cord-028721-x6f26ahr 660 12 abdominal abdominal JJ cord-028721-x6f26ahr 660 13 exploration exploration NN cord-028721-x6f26ahr 660 14 is be VBZ cord-028721-x6f26ahr 660 15 required require VBN cord-028721-x6f26ahr 660 16 to to TO cord-028721-x6f26ahr 660 17 insure insure VB cord-028721-x6f26ahr 660 18 against against IN cord-028721-x6f26ahr 660 19 an an DT cord-028721-x6f26ahr 660 20 undescended undescended JJ cord-028721-x6f26ahr 660 21 testis testis NN cord-028721-x6f26ahr 660 22 and and CC cord-028721-x6f26ahr 660 23 avoid avoid VB cord-028721-x6f26ahr 660 24 the the DT cord-028721-x6f26ahr 660 25 development development NN cord-028721-x6f26ahr 660 26 of of IN cord-028721-x6f26ahr 660 27 a a DT cord-028721-x6f26ahr 660 28 testicular testicular JJ cord-028721-x6f26ahr 660 29 tumor tumor NN cord-028721-x6f26ahr 660 30 . . . cord-028721-x6f26ahr 661 1 224 224 CD cord-028721-x6f26ahr 662 1 All all DT cord-028721-x6f26ahr 662 2 remnants remnant NNS cord-028721-x6f26ahr 662 3 found find VBN cord-028721-x6f26ahr 662 4 at at IN cord-028721-x6f26ahr 662 5 exploration exploration NN cord-028721-x6f26ahr 662 6 should should MD cord-028721-x6f26ahr 662 7 be be VB cord-028721-x6f26ahr 662 8 removed remove VBN cord-028721-x6f26ahr 662 9 . . . cord-028721-x6f26ahr 663 1 245 245 CD cord-028721-x6f26ahr 663 2 Testicular Testicular NNP cord-028721-x6f26ahr 663 3 regression regression NN cord-028721-x6f26ahr 663 4 syndrome syndrome NN cord-028721-x6f26ahr 664 1 Testicular testicular JJ cord-028721-x6f26ahr 664 2 regression regression NN cord-028721-x6f26ahr 664 3 syndrome syndrome NN cord-028721-x6f26ahr 664 4 refers refer VBZ cord-028721-x6f26ahr 664 5 to to IN cord-028721-x6f26ahr 664 6 a a DT cord-028721-x6f26ahr 664 7 variety variety NN cord-028721-x6f26ahr 664 8 of of IN cord-028721-x6f26ahr 664 9 conditions condition NNS cord-028721-x6f26ahr 664 10 , , , cord-028721-x6f26ahr 664 11 including include VBG cord-028721-x6f26ahr 664 12 agonadism agonadism NN cord-028721-x6f26ahr 664 13 , , , cord-028721-x6f26ahr 664 14 anorchidism anorchidism NN cord-028721-x6f26ahr 664 15 , , , cord-028721-x6f26ahr 664 16 testicular testicular NN cord-028721-x6f26ahr 664 17 agenesis agenesis NN cord-028721-x6f26ahr 664 18 , , , cord-028721-x6f26ahr 664 19 rudimentary rudimentary JJ cord-028721-x6f26ahr 664 20 testes testis NNS cord-028721-x6f26ahr 664 21 , , , cord-028721-x6f26ahr 664 22 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 664 23 testes testis NNS cord-028721-x6f26ahr 664 24 , , , cord-028721-x6f26ahr 664 25 and and CC cord-028721-x6f26ahr 664 26 embryonal embryonal NNP cord-028721-x6f26ahr 664 27 testicular testicular NNP cord-028721-x6f26ahr 664 28 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 664 29 . . . cord-028721-x6f26ahr 665 1 246 246 CD cord-028721-x6f26ahr 666 1 Each each DT cord-028721-x6f26ahr 666 2 of of IN cord-028721-x6f26ahr 666 3 these these DT cord-028721-x6f26ahr 666 4 syndromes syndrome NNS cord-028721-x6f26ahr 666 5 shares share VBZ cord-028721-x6f26ahr 666 6 a a DT cord-028721-x6f26ahr 666 7 complete complete JJ cord-028721-x6f26ahr 666 8 absence absence NN cord-028721-x6f26ahr 666 9 or or CC cord-028721-x6f26ahr 666 10 involution involution NN cord-028721-x6f26ahr 666 11 of of IN cord-028721-x6f26ahr 666 12 both both DT cord-028721-x6f26ahr 666 13 testes testis NNS cord-028721-x6f26ahr 666 14 247 247 CD cord-028721-x6f26ahr 666 15 but but CC cord-028721-x6f26ahr 666 16 differ differ VBP cord-028721-x6f26ahr 666 17 in in IN cord-028721-x6f26ahr 666 18 the the DT cord-028721-x6f26ahr 666 19 time time NN cord-028721-x6f26ahr 666 20 of of IN cord-028721-x6f26ahr 666 21 testicular testicular JJ cord-028721-x6f26ahr 666 22 disappearance disappearance NN cord-028721-x6f26ahr 666 23 during during IN cord-028721-x6f26ahr 666 24 development development NN cord-028721-x6f26ahr 666 25 . . . cord-028721-x6f26ahr 667 1 The the DT cord-028721-x6f26ahr 667 2 most most RBS cord-028721-x6f26ahr 667 3 frequently frequently RB cord-028721-x6f26ahr 667 4 observed observe VBN cord-028721-x6f26ahr 667 5 are be VBP cord-028721-x6f26ahr 667 6 Swyer Swyer NNP cord-028721-x6f26ahr 667 7 's 's POS cord-028721-x6f26ahr 667 8 syndrome syndrome NN cord-028721-x6f26ahr 667 9 ( ( -LRB- cord-028721-x6f26ahr 667 10 see see VB cord-028721-x6f26ahr 667 11 discussion discussion NN cord-028721-x6f26ahr 667 12 on on IN cord-028721-x6f26ahr 667 13 gonadal gonadal JJ cord-028721-x6f26ahr 667 14 dysgenesis dysgenesis FW cord-028721-x6f26ahr 667 15 below below IN cord-028721-x6f26ahr 667 16 ) ) -RRB- cord-028721-x6f26ahr 667 17 , , , cord-028721-x6f26ahr 667 18 true true JJ cord-028721-x6f26ahr 667 19 agonadism agonadism NN cord-028721-x6f26ahr 667 20 , , , cord-028721-x6f26ahr 667 21 rudimentary rudimentary JJ cord-028721-x6f26ahr 667 22 testes testis NNS cord-028721-x6f26ahr 667 23 , , , cord-028721-x6f26ahr 667 24 bilateral bilateral JJ cord-028721-x6f26ahr 667 25 anorchidism anorchidism NN cord-028721-x6f26ahr 667 26 , , , cord-028721-x6f26ahr 667 27 vanishing vanish VBG cord-028721-x6f26ahr 667 28 testes testis NNS cord-028721-x6f26ahr 667 29 syndrome syndrome NN cord-028721-x6f26ahr 667 30 , , , cord-028721-x6f26ahr 667 31 and and CC cord-028721-x6f26ahr 667 32 Leydig Leydig NNP cord-028721-x6f26ahr 667 33 cell cell NN cord-028721-x6f26ahr 667 34 - - HYPH cord-028721-x6f26ahr 667 35 only only JJ cord-028721-x6f26ahr 667 36 syndrome syndrome NN cord-028721-x6f26ahr 667 37 ( ( -LRB- cord-028721-x6f26ahr 667 38 Table Table NNP cord-028721-x6f26ahr 667 39 12 12 CD cord-028721-x6f26ahr 667 40 - - SYM cord-028721-x6f26ahr 667 41 5 5 CD cord-028721-x6f26ahr 667 42 ) ) -RRB- cord-028721-x6f26ahr 667 43 . . . cord-028721-x6f26ahr 668 1 True true JJ cord-028721-x6f26ahr 668 2 agonadism agonadism NN cord-028721-x6f26ahr 668 3 ( ( -LRB- cord-028721-x6f26ahr 668 4 46XY 46xy CD cord-028721-x6f26ahr 668 5 gonadal gonadal NNP cord-028721-x6f26ahr 668 6 agenesis agenesis NNP cord-028721-x6f26ahr 668 7 syndrome syndrome NN cord-028721-x6f26ahr 668 8 ) ) -RRB- cord-028721-x6f26ahr 669 1 Patients patient NNS cord-028721-x6f26ahr 669 2 with with IN cord-028721-x6f26ahr 669 3 true true JJ cord-028721-x6f26ahr 669 4 agonadism agonadism NN cord-028721-x6f26ahr 669 5 have have VBP cord-028721-x6f26ahr 669 6 ambiguous ambiguous JJ cord-028721-x6f26ahr 669 7 external external JJ cord-028721-x6f26ahr 669 8 genitalia genitalia NNS cord-028721-x6f26ahr 669 9 , , , cord-028721-x6f26ahr 669 10 fusion fusion NN cord-028721-x6f26ahr 669 11 of of IN cord-028721-x6f26ahr 669 12 the the DT cord-028721-x6f26ahr 669 13 labia labium NNS cord-028721-x6f26ahr 669 14 , , , cord-028721-x6f26ahr 669 15 and and CC cord-028721-x6f26ahr 669 16 a a DT cord-028721-x6f26ahr 669 17 short short JJ cord-028721-x6f26ahr 669 18 vagina vagina NN cord-028721-x6f26ahr 669 19 , , , cord-028721-x6f26ahr 669 20 refl refl NNP cord-028721-x6f26ahr 669 21 ecting ecte VBG cord-028721-x6f26ahr 669 22 very very RB cord-028721-x6f26ahr 669 23 early early JJ cord-028721-x6f26ahr 669 24 testicular testicular JJ cord-028721-x6f26ahr 669 25 regression regression NN cord-028721-x6f26ahr 669 26 ( ( -LRB- cord-028721-x6f26ahr 669 27 between between IN cord-028721-x6f26ahr 669 28 the the DT cord-028721-x6f26ahr 669 29 eighth eighth JJ cord-028721-x6f26ahr 669 30 and and CC cord-028721-x6f26ahr 669 31 12th 12th JJ cord-028721-x6f26ahr 669 32 weeks week NNS cord-028721-x6f26ahr 669 33 of of IN cord-028721-x6f26ahr 669 34 embryonal embryonal JJ cord-028721-x6f26ahr 669 35 development development NN cord-028721-x6f26ahr 669 36 ) ) -RRB- cord-028721-x6f26ahr 669 37 . . . cord-028721-x6f26ahr 670 1 The the DT cord-028721-x6f26ahr 670 2 internal internal JJ cord-028721-x6f26ahr 670 3 genitalia genitalia NNS cord-028721-x6f26ahr 670 4 consist consist VBP cord-028721-x6f26ahr 670 5 of of IN cord-028721-x6f26ahr 670 6 a a DT cord-028721-x6f26ahr 670 7 uterus uterus NN cord-028721-x6f26ahr 670 8 and and CC cord-028721-x6f26ahr 670 9 two two CD cord-028721-x6f26ahr 670 10 uterine uterine JJ cord-028721-x6f26ahr 670 11 tubes tube NNS cord-028721-x6f26ahr 670 12 , , , cord-028721-x6f26ahr 670 13 although although IN cord-028721-x6f26ahr 670 14 both both DT cord-028721-x6f26ahr 670 15 müllerian müllerian JJ cord-028721-x6f26ahr 670 16 and and CC cord-028721-x6f26ahr 670 17 wolffi wolffi NNP cord-028721-x6f26ahr 670 18 an an DT cord-028721-x6f26ahr 670 19 derivatives derivative NNS cord-028721-x6f26ahr 670 20 may may MD cord-028721-x6f26ahr 670 21 be be VB cord-028721-x6f26ahr 670 22 absent absent JJ cord-028721-x6f26ahr 670 23 . . . cord-028721-x6f26ahr 671 1 No no DT cord-028721-x6f26ahr 671 2 gonads gonad NNS cord-028721-x6f26ahr 671 3 ( ( -LRB- cord-028721-x6f26ahr 671 4 not not RB cord-028721-x6f26ahr 671 5 even even RB cord-028721-x6f26ahr 671 6 in in IN cord-028721-x6f26ahr 671 7 an an DT cord-028721-x6f26ahr 671 8 ectopic ectopic JJ cord-028721-x6f26ahr 671 9 location location NN cord-028721-x6f26ahr 671 10 ) ) -RRB- cord-028721-x6f26ahr 671 11 are be VBP cord-028721-x6f26ahr 671 12 found find VBN cord-028721-x6f26ahr 671 13 . . . cord-028721-x6f26ahr 672 1 Patients patient NNS cord-028721-x6f26ahr 672 2 are be VBP cord-028721-x6f26ahr 672 3 phenotypically phenotypically RB cord-028721-x6f26ahr 672 4 girls girl NNS cord-028721-x6f26ahr 672 5 , , , cord-028721-x6f26ahr 672 6 and and CC cord-028721-x6f26ahr 672 7 the the DT cord-028721-x6f26ahr 672 8 male male JJ cord-028721-x6f26ahr 672 9 gender gender NN cord-028721-x6f26ahr 672 10 may may MD cord-028721-x6f26ahr 672 11 be be VB cord-028721-x6f26ahr 672 12 discovered discover VBN cord-028721-x6f26ahr 672 13 only only RB cord-028721-x6f26ahr 672 14 at at IN cord-028721-x6f26ahr 672 15 the the DT cord-028721-x6f26ahr 672 16 time time NN cord-028721-x6f26ahr 672 17 of of IN cord-028721-x6f26ahr 672 18 referral referral NN cord-028721-x6f26ahr 672 19 for for IN cord-028721-x6f26ahr 672 20 other other JJ cord-028721-x6f26ahr 672 21 symptoms symptom NNS cord-028721-x6f26ahr 672 22 . . . cord-028721-x6f26ahr 673 1 248 248 CD cord-028721-x6f26ahr 674 1 Both both DT cord-028721-x6f26ahr 674 2 sporadic sporadic JJ cord-028721-x6f26ahr 674 3 and and CC cord-028721-x6f26ahr 674 4 familial familial JJ cord-028721-x6f26ahr 674 5 cases case NNS cord-028721-x6f26ahr 674 6 with with IN cord-028721-x6f26ahr 674 7 associated associated JJ cord-028721-x6f26ahr 674 8 extragenital extragenital JJ cord-028721-x6f26ahr 674 9 anomalies anomaly NNS cord-028721-x6f26ahr 674 10 have have VBP cord-028721-x6f26ahr 674 11 been be VBN cord-028721-x6f26ahr 674 12 reported report VBN cord-028721-x6f26ahr 674 13 . . . cord-028721-x6f26ahr 675 1 In in IN cord-028721-x6f26ahr 675 2 some some DT cord-028721-x6f26ahr 675 3 cases case NNS cord-028721-x6f26ahr 675 4 the the DT cord-028721-x6f26ahr 675 5 cause cause NN cord-028721-x6f26ahr 675 6 is be VBZ cord-028721-x6f26ahr 675 7 a a DT cord-028721-x6f26ahr 675 8 heterozygous heterozygous JJ cord-028721-x6f26ahr 675 9 mutation mutation NN cord-028721-x6f26ahr 675 10 of of IN cord-028721-x6f26ahr 675 11 WT1 WT1 NNP cord-028721-x6f26ahr 675 12 . . . cord-028721-x6f26ahr 676 1 249 249 CD cord-028721-x6f26ahr 677 1 In in IN cord-028721-x6f26ahr 677 2 most most JJS cord-028721-x6f26ahr 677 3 familial familial JJ cord-028721-x6f26ahr 677 4 cases case NNS cord-028721-x6f26ahr 677 5 inheritance inheritance NN cord-028721-x6f26ahr 677 6 is be VBZ cord-028721-x6f26ahr 677 7 either either CC cord-028721-x6f26ahr 677 8 recessive recessive JJ cord-028721-x6f26ahr 677 9 autonomic autonomic JJ cord-028721-x6f26ahr 677 10 or or CC cord-028721-x6f26ahr 677 11 X X NNS cord-028721-x6f26ahr 677 12 - - HYPH cord-028721-x6f26ahr 677 13 linked link VBN cord-028721-x6f26ahr 677 14 , , , cord-028721-x6f26ahr 677 15 and and CC cord-028721-x6f26ahr 677 16 the the DT cord-028721-x6f26ahr 677 17 cause cause NN cord-028721-x6f26ahr 677 18 seems seem VBZ cord-028721-x6f26ahr 677 19 to to TO cord-028721-x6f26ahr 677 20 be be VB cord-028721-x6f26ahr 677 21 either either CC cord-028721-x6f26ahr 677 22 unknown unknown JJ cord-028721-x6f26ahr 677 23 anomalies anomaly NNS cord-028721-x6f26ahr 677 24 in in IN cord-028721-x6f26ahr 677 25 the the DT cord-028721-x6f26ahr 677 26 WT1 WT1 NNP cord-028721-x6f26ahr 677 27 gene gene NN cord-028721-x6f26ahr 677 28 or or CC cord-028721-x6f26ahr 677 29 known know VBN cord-028721-x6f26ahr 677 30 anomalies anomaly NNS cord-028721-x6f26ahr 677 31 in in IN cord-028721-x6f26ahr 677 32 other other JJ cord-028721-x6f26ahr 677 33 genes gene NNS cord-028721-x6f26ahr 677 34 involved involve VBN cord-028721-x6f26ahr 677 35 in in IN cord-028721-x6f26ahr 677 36 development development NN cord-028721-x6f26ahr 677 37 . . . cord-028721-x6f26ahr 678 1 250 250 CD cord-028721-x6f26ahr 679 1 A a DT cord-028721-x6f26ahr 679 2 SRY SRY NNP cord-028721-x6f26ahr 679 3 molecular molecular JJ cord-028721-x6f26ahr 679 4 defect defect NN cord-028721-x6f26ahr 679 5 has have VBZ cord-028721-x6f26ahr 679 6 never never RB cord-028721-x6f26ahr 679 7 been be VBN cord-028721-x6f26ahr 679 8 observed observe VBN cord-028721-x6f26ahr 679 9 . . . cord-028721-x6f26ahr 680 1 251 251 CD cord-028721-x6f26ahr 680 2 Agonadism Agonadism NNP cord-028721-x6f26ahr 680 3 may may MD cord-028721-x6f26ahr 680 4 be be VB cord-028721-x6f26ahr 680 5 associ associ VBN cord-028721-x6f26ahr 680 6 - - HYPH cord-028721-x6f26ahr 680 7 ated ate VBN cord-028721-x6f26ahr 680 8 with with IN cord-028721-x6f26ahr 680 9 several several JJ cord-028721-x6f26ahr 680 10 syndromes syndrome NNS cord-028721-x6f26ahr 680 11 , , , cord-028721-x6f26ahr 680 12 including include VBG cord-028721-x6f26ahr 680 13 those those DT cord-028721-x6f26ahr 680 14 of of IN cord-028721-x6f26ahr 680 15 PAGOD PAGOD NNP cord-028721-x6f26ahr 680 16 ( ( -LRB- cord-028721-x6f26ahr 680 17 hypoplasia hypoplasia NN cord-028721-x6f26ahr 680 18 of of IN cord-028721-x6f26ahr 680 19 lungs lung NNS cord-028721-x6f26ahr 680 20 and and CC cord-028721-x6f26ahr 680 21 pulmonary pulmonary JJ cord-028721-x6f26ahr 680 22 artery artery NN cord-028721-x6f26ahr 680 23 , , , cord-028721-x6f26ahr 680 24 agonadism agonadism NN cord-028721-x6f26ahr 680 25 , , , cord-028721-x6f26ahr 680 26 omphalocele omphalocele NNP cord-028721-x6f26ahr 680 27 / / SYM cord-028721-x6f26ahr 680 28 diaphragmatic diaphragmatic JJ cord-028721-x6f26ahr 680 29 defect defect NN cord-028721-x6f26ahr 680 30 , , , cord-028721-x6f26ahr 680 31 dextrocardia dextrocardia FW cord-028721-x6f26ahr 680 32 ) ) -RRB- cord-028721-x6f26ahr 680 33 , , , cord-028721-x6f26ahr 680 34 252 252 CD cord-028721-x6f26ahr 680 35 Kennerknecht Kennerknecht NNP cord-028721-x6f26ahr 680 36 , , , cord-028721-x6f26ahr 680 37 253 253 CD cord-028721-x6f26ahr 680 38 Seckel Seckel NNP cord-028721-x6f26ahr 680 39 , , , cord-028721-x6f26ahr 680 40 254 254 CD cord-028721-x6f26ahr 680 41 and and CC cord-028721-x6f26ahr 680 42 CHARGE charge NN cord-028721-x6f26ahr 680 43 . . . cord-028721-x6f26ahr 681 1 255 255 CD cord-028721-x6f26ahr 681 2 Rudimentary rudimentary JJ cord-028721-x6f26ahr 681 3 testes testis NNS cord-028721-x6f26ahr 681 4 syndrome syndrome NN cord-028721-x6f26ahr 681 5 Patients patient NNS cord-028721-x6f26ahr 681 6 with with IN cord-028721-x6f26ahr 681 7 rudimentary rudimentary JJ cord-028721-x6f26ahr 681 8 testes testis NNS cord-028721-x6f26ahr 681 9 have have VBP cord-028721-x6f26ahr 681 10 a a DT cord-028721-x6f26ahr 681 11 normal normal JJ cord-028721-x6f26ahr 681 12 male male JJ cord-028721-x6f26ahr 681 13 phenotype phenotype NN cord-028721-x6f26ahr 681 14 . . . cord-028721-x6f26ahr 682 1 Müllerian müllerian JJ cord-028721-x6f26ahr 682 2 remnants remnant NNS cord-028721-x6f26ahr 682 3 are be VBP cord-028721-x6f26ahr 682 4 absent absent JJ cord-028721-x6f26ahr 682 5 and and CC cord-028721-x6f26ahr 682 6 wolffi wolffi NNP cord-028721-x6f26ahr 682 7 an an DT cord-028721-x6f26ahr 682 8 derivatives derivative NNS cord-028721-x6f26ahr 682 9 usually usually RB cord-028721-x6f26ahr 682 10 are be VBP cord-028721-x6f26ahr 682 11 found find VBN cord-028721-x6f26ahr 682 12 . . . cord-028721-x6f26ahr 683 1 The the DT cord-028721-x6f26ahr 683 2 testes testis NNS cord-028721-x6f26ahr 683 3 are be VBP cord-028721-x6f26ahr 683 4 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 683 5 and and CC cord-028721-x6f26ahr 683 6 very very RB cord-028721-x6f26ahr 683 7 small small JJ cord-028721-x6f26ahr 683 8 , , , cord-028721-x6f26ahr 683 9 less less JJR cord-028721-x6f26ahr 683 10 than than IN cord-028721-x6f26ahr 683 11 0.5 0.5 CD cord-028721-x6f26ahr 683 12 cm cm NNS cord-028721-x6f26ahr 683 13 long long RB cord-028721-x6f26ahr 683 14 . . . cord-028721-x6f26ahr 684 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 684 2 tubules tubule NNS cord-028721-x6f26ahr 684 3 are be VBP cord-028721-x6f26ahr 684 4 few few JJ cord-028721-x6f26ahr 685 1 ( ( -LRB- cord-028721-x6f26ahr 685 2 Fig Fig NNP cord-028721-x6f26ahr 685 3 . . . cord-028721-x6f26ahr 685 4 12 12 CD cord-028721-x6f26ahr 685 5 - - SYM cord-028721-x6f26ahr 685 6 25 25 CD cord-028721-x6f26ahr 685 7 ) ) -RRB- cord-028721-x6f26ahr 685 8 . . . cord-028721-x6f26ahr 686 1 The the DT cord-028721-x6f26ahr 686 2 testicular testicular JJ cord-028721-x6f26ahr 686 3 regression regression NN cord-028721-x6f26ahr 686 4 occurs occur VBZ cord-028721-x6f26ahr 686 5 between between IN cord-028721-x6f26ahr 686 6 the the DT cord-028721-x6f26ahr 686 7 14th 14th JJ cord-028721-x6f26ahr 686 8 and and CC cord-028721-x6f26ahr 686 9 20th 20th JJ cord-028721-x6f26ahr 686 10 weeks week NNS cord-028721-x6f26ahr 686 11 of of IN cord-028721-x6f26ahr 686 12 gestation gestation NN cord-028721-x6f26ahr 686 13 . . . cord-028721-x6f26ahr 687 1 This this DT cord-028721-x6f26ahr 687 2 syndrome syndrome NN cord-028721-x6f26ahr 687 3 has have VBZ cord-028721-x6f26ahr 687 4 been be VBN cord-028721-x6f26ahr 687 5 reported report VBN cord-028721-x6f26ahr 687 6 in in IN cord-028721-x6f26ahr 687 7 several several JJ cord-028721-x6f26ahr 687 8 members member NNS cord-028721-x6f26ahr 687 9 of of IN cord-028721-x6f26ahr 687 10 the the DT cord-028721-x6f26ahr 687 11 same same JJ cord-028721-x6f26ahr 687 12 family family NN cord-028721-x6f26ahr 687 13 , , , cord-028721-x6f26ahr 687 14 256 256 CD cord-028721-x6f26ahr 687 15 suggesting suggest VBG cord-028721-x6f26ahr 687 16 genetic genetic JJ cord-028721-x6f26ahr 687 17 transmission transmission NN cord-028721-x6f26ahr 687 18 , , , cord-028721-x6f26ahr 687 19 but but CC cord-028721-x6f26ahr 687 20 this this DT cord-028721-x6f26ahr 687 21 is be VBZ cord-028721-x6f26ahr 687 22 not not RB cord-028721-x6f26ahr 687 23 a a DT cord-028721-x6f26ahr 687 24 constant constant JJ cord-028721-x6f26ahr 687 25 feature feature NN cord-028721-x6f26ahr 687 26 . . . cord-028721-x6f26ahr 688 1 257 257 CD cord-028721-x6f26ahr 688 2 , , , cord-028721-x6f26ahr 688 3 258 258 CD cord-028721-x6f26ahr 688 4 Congenital congenital JJ cord-028721-x6f26ahr 688 5 bilateral bilateral JJ cord-028721-x6f26ahr 688 6 anorchidism anorchidism NN cord-028721-x6f26ahr 688 7 Congenital congenital JJ cord-028721-x6f26ahr 688 8 bilateral bilateral JJ cord-028721-x6f26ahr 688 9 anorchidism anorchidism NN cord-028721-x6f26ahr 688 10 occurs occur VBZ cord-028721-x6f26ahr 688 11 in in IN cord-028721-x6f26ahr 688 12 1 1 CD cord-028721-x6f26ahr 688 13 in in IN cord-028721-x6f26ahr 688 14 20 20 CD cord-028721-x6f26ahr 688 15 000 000 CD cord-028721-x6f26ahr 688 16 newborns newborn NNS cord-028721-x6f26ahr 688 17 . . . cord-028721-x6f26ahr 689 1 The the DT cord-028721-x6f26ahr 689 2 patients patient NNS cord-028721-x6f26ahr 689 3 have have VBP cord-028721-x6f26ahr 689 4 male male JJ cord-028721-x6f26ahr 689 5 external external JJ cord-028721-x6f26ahr 689 6 genitalia genitalia NNS cord-028721-x6f26ahr 689 7 , , , cord-028721-x6f26ahr 689 8 but but CC cord-028721-x6f26ahr 689 9 the the DT cord-028721-x6f26ahr 689 10 internal internal JJ cord-028721-x6f26ahr 689 11 genitalia genitalia NNS cord-028721-x6f26ahr 689 12 consist consist VBP cord-028721-x6f26ahr 689 13 only only RB cord-028721-x6f26ahr 689 14 of of IN cord-028721-x6f26ahr 689 15 normal normal JJ cord-028721-x6f26ahr 689 16 wolffi wolffi NN cord-028721-x6f26ahr 689 17 an an DT cord-028721-x6f26ahr 689 18 derivatives derivative NNS cord-028721-x6f26ahr 689 19 without without IN cord-028721-x6f26ahr 689 20 müllerian müllerian JJ cord-028721-x6f26ahr 689 21 derivatives derivative NNS cord-028721-x6f26ahr 689 22 , , , cord-028721-x6f26ahr 689 23 suggesting suggest VBG cord-028721-x6f26ahr 689 24 that that IN cord-028721-x6f26ahr 689 25 the the DT cord-028721-x6f26ahr 689 26 testes testis NNS cord-028721-x6f26ahr 689 27 were be VBD cord-028721-x6f26ahr 689 28 present present JJ cord-028721-x6f26ahr 689 29 and and CC cord-028721-x6f26ahr 689 30 functionally functionally RB cord-028721-x6f26ahr 689 31 active active JJ cord-028721-x6f26ahr 689 32 up up IN cord-028721-x6f26ahr 689 33 to to IN cord-028721-x6f26ahr 689 34 approximately approximately RB cord-028721-x6f26ahr 689 35 the the DT cord-028721-x6f26ahr 689 36 20th 20th JJ cord-028721-x6f26ahr 689 37 week week NN cord-028721-x6f26ahr 689 38 of of IN cord-028721-x6f26ahr 689 39 gestation gestation NN cord-028721-x6f26ahr 689 40 . . . cord-028721-x6f26ahr 690 1 Patients patient NNS cord-028721-x6f26ahr 690 2 have have VBP cord-028721-x6f26ahr 690 3 male male JJ cord-028721-x6f26ahr 690 4 external external JJ cord-028721-x6f26ahr 690 5 genitalia genitalia NNS cord-028721-x6f26ahr 690 6 with with IN cord-028721-x6f26ahr 690 7 hypoplasia hypoplasia NN cord-028721-x6f26ahr 690 8 of of IN cord-028721-x6f26ahr 690 9 both both CC cord-028721-x6f26ahr 690 10 the the DT cord-028721-x6f26ahr 690 11 scrotum scrotum NN cord-028721-x6f26ahr 690 12 and and CC cord-028721-x6f26ahr 690 13 penis penis NN cord-028721-x6f26ahr 690 14 . . . cord-028721-x6f26ahr 691 1 The the DT cord-028721-x6f26ahr 691 2 karyotype karyotype NN cord-028721-x6f26ahr 691 3 is be VBZ cord-028721-x6f26ahr 691 4 the the DT cord-028721-x6f26ahr 691 5 normal normal JJ cord-028721-x6f26ahr 691 6 male male NN cord-028721-x6f26ahr 691 7 . . . cord-028721-x6f26ahr 692 1 The the DT cord-028721-x6f26ahr 692 2 disorder disorder NN cord-028721-x6f26ahr 692 3 may may MD cord-028721-x6f26ahr 692 4 be be VB cord-028721-x6f26ahr 692 5 associated associate VBN cord-028721-x6f26ahr 692 6 with with IN cord-028721-x6f26ahr 692 7 other other JJ cord-028721-x6f26ahr 692 8 malformations malformation NNS cord-028721-x6f26ahr 692 9 , , , cord-028721-x6f26ahr 692 10 such such JJ cord-028721-x6f26ahr 692 11 as as IN cord-028721-x6f26ahr 692 12 anal anal JJ cord-028721-x6f26ahr 692 13 atresia atresia NN cord-028721-x6f26ahr 692 14 , , , cord-028721-x6f26ahr 692 15 rectourethral rectourethral JJ cord-028721-x6f26ahr 692 16 and and CC cord-028721-x6f26ahr 692 17 rectovaginal rectovaginal NNP cord-028721-x6f26ahr 692 18 fi fi NNP cord-028721-x6f26ahr 692 19 stula stula NN cord-028721-x6f26ahr 692 20 , , , cord-028721-x6f26ahr 692 21 and and CC cord-028721-x6f26ahr 692 22 urinary urinary JJ cord-028721-x6f26ahr 692 23 exstrophy exstrophy NN cord-028721-x6f26ahr 692 24 . . . cord-028721-x6f26ahr 693 1 Patients patient NNS cord-028721-x6f26ahr 693 2 diagnosed diagnose VBN cord-028721-x6f26ahr 693 3 at at IN cord-028721-x6f26ahr 693 4 adulthood adulthood NN cord-028721-x6f26ahr 693 5 have have VBP cord-028721-x6f26ahr 693 6 male male JJ cord-028721-x6f26ahr 693 7 phenotype phenotype NN cord-028721-x6f26ahr 693 8 , , , cord-028721-x6f26ahr 693 9 androgen androgen NN cord-028721-x6f26ahr 693 10 insuffi insuffi NN cord-028721-x6f26ahr 693 11 ciency ciency NN cord-028721-x6f26ahr 693 12 symptoms symptom NNS cord-028721-x6f26ahr 693 13 , , , cord-028721-x6f26ahr 693 14 and and CC cord-028721-x6f26ahr 693 15 elevated elevated JJ cord-028721-x6f26ahr 693 16 levels level NNS cord-028721-x6f26ahr 693 17 of of IN cord-028721-x6f26ahr 693 18 both both CC cord-028721-x6f26ahr 693 19 FSH fsh NN cord-028721-x6f26ahr 693 20 and and CC cord-028721-x6f26ahr 693 21 LH lh NN cord-028721-x6f26ahr 693 22 . . . cord-028721-x6f26ahr 694 1 259 259 CD cord-028721-x6f26ahr 694 2 , , , cord-028721-x6f26ahr 694 3 260 260 CD cord-028721-x6f26ahr 694 4 Familial familial JJ cord-028721-x6f26ahr 694 5 incidence incidence NN cord-028721-x6f26ahr 694 6 in in IN cord-028721-x6f26ahr 694 7 some some DT cord-028721-x6f26ahr 694 8 cases case NNS cord-028721-x6f26ahr 694 9 suggests suggest VBZ cord-028721-x6f26ahr 694 10 SRY SRY NNP cord-028721-x6f26ahr 694 11 gene gene NN cord-028721-x6f26ahr 694 12 mutation mutation NN cord-028721-x6f26ahr 694 13 , , , cord-028721-x6f26ahr 694 14 but but CC cord-028721-x6f26ahr 694 15 this this DT cord-028721-x6f26ahr 694 16 has have VBZ cord-028721-x6f26ahr 694 17 not not RB cord-028721-x6f26ahr 694 18 been be VBN cord-028721-x6f26ahr 694 19 confi confi VBN cord-028721-x6f26ahr 694 20 rmed rmed NNP cord-028721-x6f26ahr 694 21 . . . cord-028721-x6f26ahr 695 1 261 261 CD cord-028721-x6f26ahr 696 1 , , , cord-028721-x6f26ahr 696 2 262 262 CD cord-028721-x6f26ahr 696 3 Vanishing vanish VBG cord-028721-x6f26ahr 696 4 testes testis NNS cord-028721-x6f26ahr 696 5 syndrome syndrome NN cord-028721-x6f26ahr 697 1 This this DT cord-028721-x6f26ahr 697 2 term term NN cord-028721-x6f26ahr 697 3 refers refer VBZ cord-028721-x6f26ahr 697 4 to to IN cord-028721-x6f26ahr 697 5 the the DT cord-028721-x6f26ahr 697 6 disappearance disappearance NN cord-028721-x6f26ahr 697 7 of of IN cord-028721-x6f26ahr 697 8 one one CD cord-028721-x6f26ahr 697 9 or or CC cord-028721-x6f26ahr 697 10 both both DT cord-028721-x6f26ahr 697 11 testes testis NNS cord-028721-x6f26ahr 697 12 between between IN cord-028721-x6f26ahr 697 13 the the DT cord-028721-x6f26ahr 697 14 last last JJ cord-028721-x6f26ahr 697 15 months month NNS cord-028721-x6f26ahr 697 16 of of IN cord-028721-x6f26ahr 697 17 intrauterine intrauterine JJ cord-028721-x6f26ahr 697 18 life life NN cord-028721-x6f26ahr 697 19 and and CC cord-028721-x6f26ahr 697 20 the the DT cord-028721-x6f26ahr 697 21 beginning beginning NN cord-028721-x6f26ahr 697 22 of of IN cord-028721-x6f26ahr 697 23 puberty puberty NN cord-028721-x6f26ahr 697 24 . . . cord-028721-x6f26ahr 698 1 [ [ -LRB- cord-028721-x6f26ahr 698 2 263 263 CD cord-028721-x6f26ahr 698 3 ] ] -RRB- cord-028721-x6f26ahr 698 4 [ [ -LRB- cord-028721-x6f26ahr 698 5 264 264 CD cord-028721-x6f26ahr 698 6 ] ] -RRB- cord-028721-x6f26ahr 699 1 [ [ -LRB- cord-028721-x6f26ahr 699 2 265 265 CD cord-028721-x6f26ahr 699 3 ] ] -RRB- cord-028721-x6f26ahr 700 1 As as IN cord-028721-x6f26ahr 700 2 testicular testicular JJ cord-028721-x6f26ahr 700 3 regression regression NN cord-028721-x6f26ahr 700 4 occurs occur VBZ cord-028721-x6f26ahr 700 5 after after IN cord-028721-x6f26ahr 700 6 the the DT cord-028721-x6f26ahr 700 7 seventh seventh JJ cord-028721-x6f26ahr 700 8 month month NN cord-028721-x6f26ahr 700 9 , , , cord-028721-x6f26ahr 700 10 exploration exploration NN cord-028721-x6f26ahr 700 11 fi fi NNP cord-028721-x6f26ahr 700 12 nds nds NNP cord-028721-x6f26ahr 700 13 the the DT cord-028721-x6f26ahr 700 14 vas vas NNP cord-028721-x6f26ahr 700 15 deferens deferen NNS cord-028721-x6f26ahr 700 16 in in IN cord-028721-x6f26ahr 700 17 the the DT cord-028721-x6f26ahr 700 18 inguinal inguinal JJ cord-028721-x6f26ahr 700 19 canal canal NN cord-028721-x6f26ahr 700 20 or or CC cord-028721-x6f26ahr 700 21 high high JJ cord-028721-x6f26ahr 700 22 in in IN cord-028721-x6f26ahr 700 23 the the DT cord-028721-x6f26ahr 700 24 scrotum scrotum NN cord-028721-x6f26ahr 700 25 ; ; : cord-028721-x6f26ahr 700 26 it -PRON- PRP cord-028721-x6f26ahr 700 27 may may MD cord-028721-x6f26ahr 700 28 be be VB cord-028721-x6f26ahr 700 29 accompanied accompany VBN cord-028721-x6f26ahr 700 30 by by IN cord-028721-x6f26ahr 700 31 the the DT cord-028721-x6f26ahr 700 32 epididymis epididymis NN cord-028721-x6f26ahr 700 33 and and CC cord-028721-x6f26ahr 700 34 , , , cord-028721-x6f26ahr 700 35 less less RBR cord-028721-x6f26ahr 700 36 frequently frequently RB cord-028721-x6f26ahr 700 37 , , , cord-028721-x6f26ahr 700 38 by by IN cord-028721-x6f26ahr 700 39 testicular testicular JJ cord-028721-x6f26ahr 700 40 remnants remnant NNS cord-028721-x6f26ahr 700 41 consisting consist VBG cord-028721-x6f26ahr 700 42 of of IN cord-028721-x6f26ahr 700 43 small small JJ cord-028721-x6f26ahr 700 44 groups group NNS cord-028721-x6f26ahr 700 45 of of IN cord-028721-x6f26ahr 700 46 seminiferous seminiferous JJ cord-028721-x6f26ahr 700 47 tubules tubule NNS cord-028721-x6f26ahr 700 48 ( ( -LRB- cord-028721-x6f26ahr 700 49 Fig Fig NNP cord-028721-x6f26ahr 700 50 . . . cord-028721-x6f26ahr 700 51 12 12 CD cord-028721-x6f26ahr 700 52 - - SYM cord-028721-x6f26ahr 700 53 26 26 CD cord-028721-x6f26ahr 700 54 ) ) -RRB- cord-028721-x6f26ahr 700 55 . . . cord-028721-x6f26ahr 701 1 Patients patient NNS cord-028721-x6f26ahr 701 2 lacking lack VBG cord-028721-x6f26ahr 701 3 both both DT cord-028721-x6f26ahr 701 4 testes testis NNS cord-028721-x6f26ahr 701 5 develop develop VBP cord-028721-x6f26ahr 701 6 hypergonadotropic hypergonadotropic JJ cord-028721-x6f26ahr 701 7 hypogonadism hypogonadism NN cord-028721-x6f26ahr 701 8 after after IN cord-028721-x6f26ahr 701 9 puberty puberty NN cord-028721-x6f26ahr 701 10 , , , cord-028721-x6f26ahr 701 11 with with IN cord-028721-x6f26ahr 701 12 gynecomastia gynecomastia NN cord-028721-x6f26ahr 701 13 , , , cord-028721-x6f26ahr 701 14 infantile infantile JJ cord-028721-x6f26ahr 701 15 phallus phallus NN cord-028721-x6f26ahr 701 16 , , , cord-028721-x6f26ahr 701 17 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 701 18 scrotum scrotum NN cord-028721-x6f26ahr 701 19 , , , cord-028721-x6f26ahr 701 20 and and CC cord-028721-x6f26ahr 701 21 impalpable impalpable JJ cord-028721-x6f26ahr 701 22 prostate prostate NN cord-028721-x6f26ahr 701 23 . . . cord-028721-x6f26ahr 702 1 The the DT cord-028721-x6f26ahr 702 2 condition condition NN cord-028721-x6f26ahr 702 3 is be VBZ cord-028721-x6f26ahr 702 4 usually usually RB cord-028721-x6f26ahr 702 5 secondary secondary JJ cord-028721-x6f26ahr 702 6 to to IN cord-028721-x6f26ahr 702 7 a a DT cord-028721-x6f26ahr 702 8 perinatal perinatal JJ cord-028721-x6f26ahr 702 9 scrotal scrotal JJ cord-028721-x6f26ahr 702 10 torsion torsion NN cord-028721-x6f26ahr 702 11 , , , cord-028721-x6f26ahr 702 12 266 266 CD cord-028721-x6f26ahr 702 13 although although IN cord-028721-x6f26ahr 702 14 rarely rarely RB cord-028721-x6f26ahr 702 15 there there EX cord-028721-x6f26ahr 702 16 is be VBZ cord-028721-x6f26ahr 702 17 a a DT cord-028721-x6f26ahr 702 18 genetic genetic JJ cord-028721-x6f26ahr 702 19 cause cause NN cord-028721-x6f26ahr 702 20 . . . cord-028721-x6f26ahr 703 1 267 267 CD cord-028721-x6f26ahr 703 2 , , , cord-028721-x6f26ahr 703 3 268 268 CD cord-028721-x6f26ahr 704 1 Leydig leydig NN cord-028721-x6f26ahr 704 2 cell cell NN cord-028721-x6f26ahr 704 3 - - HYPH cord-028721-x6f26ahr 704 4 only only RB cord-028721-x6f26ahr 704 5 syndrome syndrome NN cord-028721-x6f26ahr 704 6 Patients patient NNS cord-028721-x6f26ahr 704 7 with with IN cord-028721-x6f26ahr 704 8 Leydig Leydig NNP cord-028721-x6f26ahr 704 9 cell cell NN cord-028721-x6f26ahr 704 10 - - HYPH cord-028721-x6f26ahr 704 11 only only JJ cord-028721-x6f26ahr 704 12 syndrome syndrome NN cord-028721-x6f26ahr 704 13 have have VBP cord-028721-x6f26ahr 704 14 agonadism agonadism NN cord-028721-x6f26ahr 704 15 without without IN cord-028721-x6f26ahr 704 16 eunuchoidism eunuchoidism NN cord-028721-x6f26ahr 704 17 and and CC cord-028721-x6f26ahr 704 18 a a DT cord-028721-x6f26ahr 704 19 normal normal JJ cord-028721-x6f26ahr 704 20 male male JJ cord-028721-x6f26ahr 704 21 phenotype phenotype NN cord-028721-x6f26ahr 704 22 , , , cord-028721-x6f26ahr 704 23 although although IN cord-028721-x6f26ahr 704 24 meticulous meticulous JJ cord-028721-x6f26ahr 704 25 surgical surgical JJ cord-028721-x6f26ahr 704 26 exploration exploration NN cord-028721-x6f26ahr 704 27 fails fail VBZ cord-028721-x6f26ahr 704 28 to to TO cord-028721-x6f26ahr 704 29 fi fi VB cord-028721-x6f26ahr 704 30 nd nd NNP cord-028721-x6f26ahr 704 31 testicular testicular NN cord-028721-x6f26ahr 704 32 remnants remnant NNS cord-028721-x6f26ahr 704 33 . . . cord-028721-x6f26ahr 705 1 Study study NN cord-028721-x6f26ahr 705 2 of of IN cord-028721-x6f26ahr 705 3 serial serial JJ cord-028721-x6f26ahr 705 4 sections section NNS cord-028721-x6f26ahr 705 5 from from IN cord-028721-x6f26ahr 705 6 the the DT cord-028721-x6f26ahr 705 7 spermatic spermatic JJ cord-028721-x6f26ahr 705 8 cord cord NN cord-028721-x6f26ahr 705 9 reveals reveal VBZ cord-028721-x6f26ahr 705 10 clusters cluster NNS cord-028721-x6f26ahr 705 11 of of IN cord-028721-x6f26ahr 705 12 Leydig Leydig NNP cord-028721-x6f26ahr 705 13 cells cell NNS cord-028721-x6f26ahr 705 14 . . . cord-028721-x6f26ahr 706 1 269 269 CD cord-028721-x6f26ahr 706 2 Detection detection NN cord-028721-x6f26ahr 706 3 of of IN cord-028721-x6f26ahr 706 4 testosterone testosterone NN cord-028721-x6f26ahr 706 5 in in IN cord-028721-x6f26ahr 706 6 spermatic spermatic JJ cord-028721-x6f26ahr 706 7 vein vein NN cord-028721-x6f26ahr 706 8 blood blood NN cord-028721-x6f26ahr 706 9 indicates indicate VBZ cord-028721-x6f26ahr 706 10 that that IN cord-028721-x6f26ahr 706 11 these these DT cord-028721-x6f26ahr 706 12 ectopic ectopic JJ cord-028721-x6f26ahr 706 13 Leydig Leydig NNP cord-028721-x6f26ahr 706 14 cells cell NNS cord-028721-x6f26ahr 706 15 are be VBP cord-028721-x6f26ahr 706 16 functionally functionally RB cord-028721-x6f26ahr 706 17 active active JJ cord-028721-x6f26ahr 706 18 and and CC cord-028721-x6f26ahr 706 19 synthesize synthesize VB cord-028721-x6f26ahr 706 20 testosterone testosterone NN cord-028721-x6f26ahr 706 21 in in IN cord-028721-x6f26ahr 706 22 amounts amount NNS cord-028721-x6f26ahr 706 23 suffi suffi NNP cord-028721-x6f26ahr 706 24 cient cient NNP cord-028721-x6f26ahr 706 25 to to TO cord-028721-x6f26ahr 706 26 induce induce VB cord-028721-x6f26ahr 706 27 a a DT cord-028721-x6f26ahr 706 28 rudimentary rudimentary JJ cord-028721-x6f26ahr 706 29 male male JJ cord-028721-x6f26ahr 706 30 phenotype phenotype NN cord-028721-x6f26ahr 706 31 but but CC cord-028721-x6f26ahr 706 32 insuffi insuffi NNP cord-028721-x6f26ahr 706 33 cient cient NNP cord-028721-x6f26ahr 706 34 to to TO cord-028721-x6f26ahr 706 35 support support VB cord-028721-x6f26ahr 706 36 the the DT cord-028721-x6f26ahr 706 37 complete complete JJ cord-028721-x6f26ahr 706 38 development development NN cord-028721-x6f26ahr 706 39 of of IN cord-028721-x6f26ahr 706 40 secondary secondary JJ cord-028721-x6f26ahr 706 41 sex sex NN cord-028721-x6f26ahr 706 42 characteristics characteristic NNS cord-028721-x6f26ahr 706 43 . . . cord-028721-x6f26ahr 707 1 The the DT cord-028721-x6f26ahr 707 2 morphology morphology NN cord-028721-x6f26ahr 707 3 of of IN cord-028721-x6f26ahr 707 4 spermatic spermatic JJ cord-028721-x6f26ahr 707 5 cord cord NN cord-028721-x6f26ahr 707 6 remnants remnant NNS cord-028721-x6f26ahr 707 7 is be VBZ cord-028721-x6f26ahr 707 8 similar similar JJ cord-028721-x6f26ahr 707 9 in in IN cord-028721-x6f26ahr 707 10 monorchidism monorchidism NN cord-028721-x6f26ahr 707 11 and and CC cord-028721-x6f26ahr 707 12 testicular testicular JJ cord-028721-x6f26ahr 707 13 regression regression NN cord-028721-x6f26ahr 707 14 syndrome syndrome NN cord-028721-x6f26ahr 707 15 occurring occur VBG cord-028721-x6f26ahr 707 16 after after IN cord-028721-x6f26ahr 707 17 the the DT cord-028721-x6f26ahr 707 18 20th 20th JJ cord-028721-x6f26ahr 707 19 week week NN cord-028721-x6f26ahr 707 20 of of IN cord-028721-x6f26ahr 707 21 gestation gestation NN cord-028721-x6f26ahr 707 22 . . . cord-028721-x6f26ahr 708 1 [ [ -LRB- cord-028721-x6f26ahr 708 2 270 270 CD cord-028721-x6f26ahr 708 3 ] ] -RRB- cord-028721-x6f26ahr 708 4 [ [ -LRB- cord-028721-x6f26ahr 708 5 271 271 CD cord-028721-x6f26ahr 708 6 ] ] -RRB- cord-028721-x6f26ahr 709 1 [ [ -LRB- cord-028721-x6f26ahr 709 2 272 272 CD cord-028721-x6f26ahr 709 3 ] ] -RRB- cord-028721-x6f26ahr 710 1 Grossly grossly RB cord-028721-x6f26ahr 710 2 , , , cord-028721-x6f26ahr 710 3 a a DT cord-028721-x6f26ahr 710 4 small small JJ cord-028721-x6f26ahr 710 5 , , , cord-028721-x6f26ahr 710 6 fi fi NNP cord-028721-x6f26ahr 710 7 rm rm NNP cord-028721-x6f26ahr 710 8 mass mass NNP cord-028721-x6f26ahr 710 9 is be VBZ cord-028721-x6f26ahr 710 10 found find VBN cord-028721-x6f26ahr 710 11 at at IN cord-028721-x6f26ahr 710 12 the the DT cord-028721-x6f26ahr 710 13 end end NN cord-028721-x6f26ahr 710 14 of of IN cord-028721-x6f26ahr 710 15 the the DT cord-028721-x6f26ahr 710 16 cord cord NN cord-028721-x6f26ahr 710 17 ( ( -LRB- cord-028721-x6f26ahr 710 18 Fig fig NN cord-028721-x6f26ahr 710 19 . . . cord-028721-x6f26ahr 711 1 12 12 CD cord-028721-x6f26ahr 711 2 - - SYM cord-028721-x6f26ahr 711 3 27 27 CD cord-028721-x6f26ahr 711 4 ) ) -RRB- cord-028721-x6f26ahr 711 5 . . . cord-028721-x6f26ahr 712 1 Histologic Histologic NNP cord-028721-x6f26ahr 712 2 examination examination NN cord-028721-x6f26ahr 712 3 reveals reveal VBZ cord-028721-x6f26ahr 712 4 vas vas NNP cord-028721-x6f26ahr 712 5 deferens deferen NNS cord-028721-x6f26ahr 712 6 , , , cord-028721-x6f26ahr 712 7 epididymis epididymis NN cord-028721-x6f26ahr 712 8 , , , cord-028721-x6f26ahr 712 9 or or CC cord-028721-x6f26ahr 712 10 small small JJ cord-028721-x6f26ahr 712 11 groups group NNS cord-028721-x6f26ahr 712 12 of of IN cord-028721-x6f26ahr 712 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 712 14 tubules tubule NNS cord-028721-x6f26ahr 712 15 in in IN cord-028721-x6f26ahr 712 16 69 69 CD cord-028721-x6f26ahr 712 17 - - SYM cord-028721-x6f26ahr 712 18 83 83 CD cord-028721-x6f26ahr 712 19 % % NN cord-028721-x6f26ahr 712 20 of of IN cord-028721-x6f26ahr 712 21 cases case NNS cord-028721-x6f26ahr 712 22 . . . cord-028721-x6f26ahr 713 1 273 273 CD cord-028721-x6f26ahr 713 2 Vas Vas NNP cord-028721-x6f26ahr 713 3 deferens deferens NN cord-028721-x6f26ahr 713 4 is be VBZ cord-028721-x6f26ahr 713 5 the the DT cord-028721-x6f26ahr 713 6 most most RBS cord-028721-x6f26ahr 713 7 constant constant JJ cord-028721-x6f26ahr 713 8 fi fi NN cord-028721-x6f26ahr 713 9 nding nding NN cord-028721-x6f26ahr 713 10 ( ( -LRB- cord-028721-x6f26ahr 713 11 79 79 CD cord-028721-x6f26ahr 713 12 % % NN cord-028721-x6f26ahr 713 13 ) ) -RRB- cord-028721-x6f26ahr 713 14 , , , cord-028721-x6f26ahr 713 15 followed follow VBN cord-028721-x6f26ahr 713 16 by by IN cord-028721-x6f26ahr 713 17 epididymis epididymis NN cord-028721-x6f26ahr 713 18 ( ( -LRB- cord-028721-x6f26ahr 713 19 36 36 CD cord-028721-x6f26ahr 713 20 % % NN cord-028721-x6f26ahr 713 21 ) ) -RRB- cord-028721-x6f26ahr 713 22 and and CC cord-028721-x6f26ahr 713 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 713 24 tubules tubule NNS cord-028721-x6f26ahr 713 25 ( ( -LRB- cord-028721-x6f26ahr 713 26 5 5 CD cord-028721-x6f26ahr 713 27 - - SYM cord-028721-x6f26ahr 713 28 13 13 CD cord-028721-x6f26ahr 713 29 % % NN cord-028721-x6f26ahr 713 30 ) ) -RRB- cord-028721-x6f26ahr 713 31 . . . cord-028721-x6f26ahr 714 1 The the DT cord-028721-x6f26ahr 714 2 spermatic spermatic JJ cord-028721-x6f26ahr 714 3 vessels vessel NNS cord-028721-x6f26ahr 714 4 are be VBP cord-028721-x6f26ahr 714 5 abnormally abnormally RB cord-028721-x6f26ahr 714 6 small small JJ cord-028721-x6f26ahr 714 7 in in IN cord-028721-x6f26ahr 714 8 83 83 CD cord-028721-x6f26ahr 714 9 % % NN cord-028721-x6f26ahr 714 10 of of IN cord-028721-x6f26ahr 714 11 cases case NNS cord-028721-x6f26ahr 714 12 . . . cord-028721-x6f26ahr 715 1 245 245 CD cord-028721-x6f26ahr 715 2 , , , cord-028721-x6f26ahr 715 3 274 274 CD cord-028721-x6f26ahr 715 4 Areas area NNS cord-028721-x6f26ahr 715 5 of of IN cord-028721-x6f26ahr 715 6 dystrophic dystrophic NNP cord-028721-x6f26ahr 715 7 calcifi calcifi NNP cord-028721-x6f26ahr 715 8 cation cation NNP cord-028721-x6f26ahr 715 9 , , , cord-028721-x6f26ahr 715 10 hemosiderin hemosiderin NNP cord-028721-x6f26ahr 715 11 deposition deposition NN cord-028721-x6f26ahr 715 12 , , , cord-028721-x6f26ahr 715 13 and and CC cord-028721-x6f26ahr 715 14 giant giant JJ cord-028721-x6f26ahr 715 15 cell cell NN cord-028721-x6f26ahr 715 16 reaction reaction NN cord-028721-x6f26ahr 715 17 may may MD cord-028721-x6f26ahr 715 18 be be VB cord-028721-x6f26ahr 715 19 found find VBN cord-028721-x6f26ahr 715 20 within within IN cord-028721-x6f26ahr 715 21 the the DT cord-028721-x6f26ahr 715 22 mass mass NN cord-028721-x6f26ahr 715 23 in in IN cord-028721-x6f26ahr 715 24 place place NN cord-028721-x6f26ahr 715 25 of of IN cord-028721-x6f26ahr 715 26 the the DT cord-028721-x6f26ahr 715 27 testis testis NN cord-028721-x6f26ahr 715 28 . . . cord-028721-x6f26ahr 716 1 Other other JJ cord-028721-x6f26ahr 716 2 fi fi NN cord-028721-x6f26ahr 716 3 ndings nding NNS cord-028721-x6f26ahr 716 4 include include VBP cord-028721-x6f26ahr 716 5 arterial arterial JJ cord-028721-x6f26ahr 716 6 and and CC cord-028721-x6f26ahr 716 7 venous venous JJ cord-028721-x6f26ahr 716 8 vessels vessel NNS cord-028721-x6f26ahr 716 9 ( ( -LRB- cord-028721-x6f26ahr 716 10 88 88 CD cord-028721-x6f26ahr 716 11 % % NN cord-028721-x6f26ahr 716 12 ) ) -RRB- cord-028721-x6f26ahr 716 13 , , , cord-028721-x6f26ahr 716 14 fat fat JJ cord-028721-x6f26ahr 716 15 ( ( -LRB- cord-028721-x6f26ahr 716 16 44 44 CD cord-028721-x6f26ahr 716 17 % % NN cord-028721-x6f26ahr 716 18 ) ) -RRB- cord-028721-x6f26ahr 716 19 , , , cord-028721-x6f26ahr 716 20 and and CC cord-028721-x6f26ahr 716 21 nerves nerve NNS cord-028721-x6f26ahr 716 22 that that WDT cord-028721-x6f26ahr 716 23 may may MD cord-028721-x6f26ahr 716 24 resemble resemble VB cord-028721-x6f26ahr 716 25 traumatic traumatic JJ cord-028721-x6f26ahr 716 26 neuroma neuroma NN cord-028721-x6f26ahr 716 27 ( ( -LRB- cord-028721-x6f26ahr 716 28 56 56 CD cord-028721-x6f26ahr 716 29 % % NN cord-028721-x6f26ahr 716 30 ) ) -RRB- cord-028721-x6f26ahr 716 31 . . . cord-028721-x6f26ahr 717 1 The the DT cord-028721-x6f26ahr 717 2 minimal minimal JJ cord-028721-x6f26ahr 717 3 requirement requirement NN cord-028721-x6f26ahr 717 4 to to TO cord-028721-x6f26ahr 717 5 diagnose diagnose VB cord-028721-x6f26ahr 717 6 vanishing vanish VBG cord-028721-x6f26ahr 717 7 testis testis NN cord-028721-x6f26ahr 717 8 is be VBZ cord-028721-x6f26ahr 717 9 to to TO cord-028721-x6f26ahr 717 10 fi fi VB cord-028721-x6f26ahr 717 11 nd nd NNP cord-028721-x6f26ahr 717 12 either either CC cord-028721-x6f26ahr 717 13 a a DT cord-028721-x6f26ahr 717 14 vascularized vascularized JJ cord-028721-x6f26ahr 717 15 fi fi NN cord-028721-x6f26ahr 717 16 brous brous JJ cord-028721-x6f26ahr 717 17 nodule nodule NN cord-028721-x6f26ahr 717 18 with with IN cord-028721-x6f26ahr 717 19 calcifi calcifi NNP cord-028721-x6f26ahr 717 20 cation cation NNP cord-028721-x6f26ahr 717 21 or or CC cord-028721-x6f26ahr 717 22 hemosiderin hemosiderin NNP cord-028721-x6f26ahr 717 23 , , , cord-028721-x6f26ahr 717 24 or or CC cord-028721-x6f26ahr 717 25 a a DT cord-028721-x6f26ahr 717 26 fi fi NN cord-028721-x6f26ahr 717 27 brous brous JJ cord-028721-x6f26ahr 717 28 nodule nodule NN cord-028721-x6f26ahr 717 29 with with IN cord-028721-x6f26ahr 717 30 cord cord NN cord-028721-x6f26ahr 717 31 elements element NNS cord-028721-x6f26ahr 717 32 . . . cord-028721-x6f26ahr 718 1 275 275 CD cord-028721-x6f26ahr 719 1 It -PRON- PRP cord-028721-x6f26ahr 719 2 has have VBZ cord-028721-x6f26ahr 719 3 been be VBN cord-028721-x6f26ahr 719 4 proposed propose VBN cord-028721-x6f26ahr 719 5 that that IN cord-028721-x6f26ahr 719 6 removal removal NN cord-028721-x6f26ahr 719 7 of of IN cord-028721-x6f26ahr 719 8 the the DT cord-028721-x6f26ahr 719 9 testicular testicular JJ cord-028721-x6f26ahr 719 10 nubbin nubbin NN cord-028721-x6f26ahr 719 11 in in IN cord-028721-x6f26ahr 719 12 this this DT cord-028721-x6f26ahr 719 13 syndrome syndrome NN cord-028721-x6f26ahr 719 14 may may MD cord-028721-x6f26ahr 719 15 not not RB cord-028721-x6f26ahr 719 16 be be VB cord-028721-x6f26ahr 719 17 required require VBN cord-028721-x6f26ahr 719 18 because because IN cord-028721-x6f26ahr 719 19 the the DT cord-028721-x6f26ahr 719 20 percentage percentage NN cord-028721-x6f26ahr 719 21 of of IN cord-028721-x6f26ahr 719 22 seminiferous seminiferous JJ cord-028721-x6f26ahr 719 23 tubules tubule NNS cord-028721-x6f26ahr 719 24 is be VBZ cord-028721-x6f26ahr 719 25 very very RB cord-028721-x6f26ahr 719 26 low low JJ cord-028721-x6f26ahr 719 27 and and CC cord-028721-x6f26ahr 719 28 the the DT cord-028721-x6f26ahr 719 29 presence presence NN cord-028721-x6f26ahr 719 30 of of IN cord-028721-x6f26ahr 719 31 germ germ NN cord-028721-x6f26ahr 719 32 cells cell NNS cord-028721-x6f26ahr 719 33 low low JJ cord-028721-x6f26ahr 719 34 , , , cord-028721-x6f26ahr 719 35 and and CC cord-028721-x6f26ahr 719 36 thus thus RB cord-028721-x6f26ahr 719 37 the the DT cord-028721-x6f26ahr 719 38 probability probability NN cord-028721-x6f26ahr 719 39 of of IN cord-028721-x6f26ahr 719 40 a a DT cord-028721-x6f26ahr 719 41 tumor tumor NN cord-028721-x6f26ahr 719 42 is be VBZ cord-028721-x6f26ahr 719 43 minimal minimal JJ cord-028721-x6f26ahr 719 44 . . . cord-028721-x6f26ahr 720 1 276 276 CD cord-028721-x6f26ahr 720 2 , , , cord-028721-x6f26ahr 720 3 277 277 CD cord-028721-x6f26ahr 721 1 The the DT cord-028721-x6f26ahr 721 2 general general JJ cord-028721-x6f26ahr 721 3 recommendation recommendation NN cord-028721-x6f26ahr 721 4 is be VBZ cord-028721-x6f26ahr 721 5 scrotal scrotal JJ cord-028721-x6f26ahr 721 6 exploration exploration NN cord-028721-x6f26ahr 721 7 as as IN cord-028721-x6f26ahr 721 8 a a DT cord-028721-x6f26ahr 721 9 fi fi NN cord-028721-x6f26ahr 721 10 rst rst NN cord-028721-x6f26ahr 721 11 step step NN cord-028721-x6f26ahr 721 12 , , , cord-028721-x6f26ahr 721 13 reserving reserve VBG cord-028721-x6f26ahr 721 14 laparoscopy laparoscopy NN cord-028721-x6f26ahr 721 15 for for IN cord-028721-x6f26ahr 721 16 cases case NNS cord-028721-x6f26ahr 721 17 in in IN cord-028721-x6f26ahr 721 18 which which WDT cord-028721-x6f26ahr 721 19 either either CC cord-028721-x6f26ahr 721 20 the the DT cord-028721-x6f26ahr 721 21 atrophic atrophic JJ cord-028721-x6f26ahr 721 22 remnant remnant NN cord-028721-x6f26ahr 721 23 can can MD cord-028721-x6f26ahr 721 24 not not RB cord-028721-x6f26ahr 721 25 be be VB cord-028721-x6f26ahr 721 26 identifi identifi VBN cord-028721-x6f26ahr 721 27 ed ed NN cord-028721-x6f26ahr 721 28 during during IN cord-028721-x6f26ahr 721 29 scrotal scrotal JJ cord-028721-x6f26ahr 721 30 exploration exploration NN cord-028721-x6f26ahr 721 31 or or CC cord-028721-x6f26ahr 721 32 has have VBZ cord-028721-x6f26ahr 721 33 a a DT cord-028721-x6f26ahr 721 34 patent patent NN cord-028721-x6f26ahr 721 35 vaginal vaginal JJ cord-028721-x6f26ahr 721 36 process process NN cord-028721-x6f26ahr 721 37 . . . cord-028721-x6f26ahr 722 1 266 266 CD cord-028721-x6f26ahr 722 2 _SP cord-028721-x6f26ahr 723 1 The the DT cord-028721-x6f26ahr 723 2 histologic histologic JJ cord-028721-x6f26ahr 723 3 fi fi NN cord-028721-x6f26ahr 723 4 ndings nding NNS cord-028721-x6f26ahr 723 5 suggest suggest VBP cord-028721-x6f26ahr 723 6 that that IN cord-028721-x6f26ahr 723 7 most most JJS cord-028721-x6f26ahr 723 8 cases case NNS cord-028721-x6f26ahr 723 9 of of IN cord-028721-x6f26ahr 723 10 unilateral unilateral JJ cord-028721-x6f26ahr 723 11 and and CC cord-028721-x6f26ahr 723 12 bilateral bilateral JJ cord-028721-x6f26ahr 723 13 anorchidism anorchidism NN cord-028721-x6f26ahr 723 14 are be VBP cord-028721-x6f26ahr 723 15 produced produce VBN cord-028721-x6f26ahr 723 16 during during IN cord-028721-x6f26ahr 723 17 the the DT cord-028721-x6f26ahr 723 18 fetal fetal JJ cord-028721-x6f26ahr 723 19 period period NN cord-028721-x6f26ahr 723 20 after after IN cord-028721-x6f26ahr 723 21 the the DT cord-028721-x6f26ahr 723 22 testis testis NN cord-028721-x6f26ahr 723 23 has have VBZ cord-028721-x6f26ahr 723 24 inhibited inhibit VBN cord-028721-x6f26ahr 723 25 the the DT cord-028721-x6f26ahr 723 26 müllerian müllerian JJ cord-028721-x6f26ahr 723 27 ducts duct NNS cord-028721-x6f26ahr 723 28 and and CC cord-028721-x6f26ahr 723 29 induced induce VBN cord-028721-x6f26ahr 723 30 differentiation differentiation NN cord-028721-x6f26ahr 723 31 of of IN cord-028721-x6f26ahr 723 32 wolffi wolffi NNP cord-028721-x6f26ahr 723 33 an an DT cord-028721-x6f26ahr 723 34 duct duct NN cord-028721-x6f26ahr 723 35 derivatives derivative NNS cord-028721-x6f26ahr 723 36 . . . cord-028721-x6f26ahr 724 1 Two two CD cord-028721-x6f26ahr 724 2 hypotheses hypothesis NNS cord-028721-x6f26ahr 724 3 account account VBP cord-028721-x6f26ahr 724 4 for for IN cord-028721-x6f26ahr 724 5 the the DT cord-028721-x6f26ahr 724 6 disappearance disappearance NN cord-028721-x6f26ahr 724 7 of of IN cord-028721-x6f26ahr 724 8 the the DT cord-028721-x6f26ahr 724 9 testes testis NNS cord-028721-x6f26ahr 724 10 : : : cord-028721-x6f26ahr 724 11 primary primary JJ cord-028721-x6f26ahr 724 12 anomaly anomaly NN cord-028721-x6f26ahr 724 13 of of IN cord-028721-x6f26ahr 724 14 the the DT cord-028721-x6f26ahr 724 15 gonad gonad NN cord-028721-x6f26ahr 724 16 ; ; : cord-028721-x6f26ahr 724 17 and and CC cord-028721-x6f26ahr 724 18 atrophy atrophy NN cord-028721-x6f26ahr 724 19 secondary secondary JJ cord-028721-x6f26ahr 724 20 to to IN cord-028721-x6f26ahr 724 21 a a DT cord-028721-x6f26ahr 724 22 vascular vascular JJ cord-028721-x6f26ahr 724 23 lesion lesion NN cord-028721-x6f26ahr 724 24 such such JJ cord-028721-x6f26ahr 724 25 as as IN cord-028721-x6f26ahr 724 26 thrombosis thrombosis NN cord-028721-x6f26ahr 724 27 or or CC cord-028721-x6f26ahr 724 28 intrauterine intrauterine JJ cord-028721-x6f26ahr 724 29 torsion torsion NN cord-028721-x6f26ahr 724 30 . . . cord-028721-x6f26ahr 725 1 The the DT cord-028721-x6f26ahr 725 2 presence presence NN cord-028721-x6f26ahr 725 3 of of IN cord-028721-x6f26ahr 725 4 macrophages macrophage NNS cord-028721-x6f26ahr 725 5 with with IN cord-028721-x6f26ahr 725 6 hemosiderin hemosiderin NNP cord-028721-x6f26ahr 725 7 and and CC cord-028721-x6f26ahr 725 8 dystrophic dystrophic NNP cord-028721-x6f26ahr 725 9 calcifi calcifi NNP cord-028721-x6f26ahr 725 10 cation cation NNP cord-028721-x6f26ahr 725 11 supports support VBZ cord-028721-x6f26ahr 725 12 the the DT cord-028721-x6f26ahr 725 13 latter latter JJ cord-028721-x6f26ahr 725 14 . . . cord-028721-x6f26ahr 726 1 Absence absence NN cord-028721-x6f26ahr 726 2 of of IN cord-028721-x6f26ahr 726 3 one one CD cord-028721-x6f26ahr 726 4 testis testis NN cord-028721-x6f26ahr 726 5 may may MD cord-028721-x6f26ahr 726 6 be be VB cord-028721-x6f26ahr 726 7 associated associate VBN cord-028721-x6f26ahr 726 8 with with IN cord-028721-x6f26ahr 726 9 malformations malformation NNS cord-028721-x6f26ahr 726 10 of of IN cord-028721-x6f26ahr 726 11 the the DT cord-028721-x6f26ahr 726 12 urogenital urogenital JJ cord-028721-x6f26ahr 726 13 system system NN cord-028721-x6f26ahr 726 14 , , , cord-028721-x6f26ahr 726 15 such such JJ cord-028721-x6f26ahr 726 16 as as IN cord-028721-x6f26ahr 726 17 absence absence NN cord-028721-x6f26ahr 726 18 of of IN cord-028721-x6f26ahr 726 19 the the DT cord-028721-x6f26ahr 726 20 kidney kidney NN cord-028721-x6f26ahr 726 21 , , , cord-028721-x6f26ahr 726 22 cystic cystic JJ cord-028721-x6f26ahr 726 23 seminal seminal JJ cord-028721-x6f26ahr 726 24 vesicles vesicle NNS cord-028721-x6f26ahr 726 25 , , , cord-028721-x6f26ahr 726 26 and and CC cord-028721-x6f26ahr 726 27 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 726 28 renal renal JJ cord-028721-x6f26ahr 726 29 dysgenesis dysgenesis NN cord-028721-x6f26ahr 726 30 . . . cord-028721-x6f26ahr 727 1 278 278 CD cord-028721-x6f26ahr 727 2 , , , cord-028721-x6f26ahr 727 3 279 279 CD cord-028721-x6f26ahr 727 4 _SP cord-028721-x6f26ahr 728 1 This this DT cord-028721-x6f26ahr 728 2 clinical clinical JJ cord-028721-x6f26ahr 728 3 term term NN cord-028721-x6f26ahr 728 4 refers refer VBZ cord-028721-x6f26ahr 728 5 to to IN cord-028721-x6f26ahr 728 6 diverse diverse JJ cord-028721-x6f26ahr 728 7 conditions condition NNS cord-028721-x6f26ahr 728 8 ( ( -LRB- cord-028721-x6f26ahr 728 9 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 728 10 's 's POS cord-028721-x6f26ahr 728 11 syndrome syndrome NN cord-028721-x6f26ahr 728 12 , , , cord-028721-x6f26ahr 728 13 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 728 14 hypogonadism hypogonadism NN cord-028721-x6f26ahr 728 15 , , , cord-028721-x6f26ahr 728 16 rudimentary rudimentary JJ cord-028721-x6f26ahr 728 17 testes testis NNS cord-028721-x6f26ahr 728 18 syndrome syndrome NN cord-028721-x6f26ahr 728 19 , , , cord-028721-x6f26ahr 728 20 bilateral bilateral JJ cord-028721-x6f26ahr 728 21 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 728 22 , , , cord-028721-x6f26ahr 728 23 etc etc FW cord-028721-x6f26ahr 728 24 . . . cord-028721-x6f26ahr 728 25 ) ) -RRB- cord-028721-x6f26ahr 729 1 that that DT cord-028721-x6f26ahr 729 2 share share VBP cord-028721-x6f26ahr 729 3 small small JJ cord-028721-x6f26ahr 729 4 testicular testicular JJ cord-028721-x6f26ahr 729 5 size size NN cord-028721-x6f26ahr 729 6 . . . cord-028721-x6f26ahr 730 1 280 280 CD cord-028721-x6f26ahr 730 2 , , , cord-028721-x6f26ahr 730 3 281 281 CD cord-028721-x6f26ahr 730 4 A a DT cord-028721-x6f26ahr 730 5 peculiar peculiar JJ cord-028721-x6f26ahr 730 6 case case NN cord-028721-x6f26ahr 730 7 is be VBZ cord-028721-x6f26ahr 730 8 presented present VBN cord-028721-x6f26ahr 730 9 by by IN cord-028721-x6f26ahr 730 10 some some DT cord-028721-x6f26ahr 730 11 patients patient NNS cord-028721-x6f26ahr 730 12 with with IN cord-028721-x6f26ahr 730 13 Kenny Kenny NNP cord-028721-x6f26ahr 730 14 - - HYPH cord-028721-x6f26ahr 730 15 Caffey Caffey NNP cord-028721-x6f26ahr 730 16 syndrome syndrome NN cord-028721-x6f26ahr 730 17 : : : cord-028721-x6f26ahr 730 18 short short JJ cord-028721-x6f26ahr 730 19 stature stature NN cord-028721-x6f26ahr 730 20 , , , cord-028721-x6f26ahr 730 21 cortical cortical JJ cord-028721-x6f26ahr 730 22 thickening thickening NN cord-028721-x6f26ahr 730 23 and and CC cord-028721-x6f26ahr 730 24 medullary medullary JJ cord-028721-x6f26ahr 730 25 stenosis stenosis NN cord-028721-x6f26ahr 730 26 of of IN cord-028721-x6f26ahr 730 27 long long JJ cord-028721-x6f26ahr 730 28 bones bone NNS cord-028721-x6f26ahr 730 29 , , , cord-028721-x6f26ahr 730 30 delayed delay VBN cord-028721-x6f26ahr 730 31 closure closure NN cord-028721-x6f26ahr 730 32 of of IN cord-028721-x6f26ahr 730 33 anterior anterior JJ cord-028721-x6f26ahr 730 34 fontanelles fontanelle NNS cord-028721-x6f26ahr 730 35 , , , cord-028721-x6f26ahr 730 36 hypoparathyroidism hypoparathyroidism NNP cord-028721-x6f26ahr 730 37 , , , cord-028721-x6f26ahr 730 38 and and CC cord-028721-x6f26ahr 730 39 several several JJ cord-028721-x6f26ahr 730 40 ocular ocular JJ cord-028721-x6f26ahr 730 41 alterations alteration NNS cord-028721-x6f26ahr 730 42 . . . cord-028721-x6f26ahr 731 1 FSH fsh NN cord-028721-x6f26ahr 731 2 serum serum NN cord-028721-x6f26ahr 731 3 levels level NNS cord-028721-x6f26ahr 731 4 are be VBP cord-028721-x6f26ahr 731 5 elevated elevate VBN cord-028721-x6f26ahr 731 6 , , , cord-028721-x6f26ahr 731 7 but but CC cord-028721-x6f26ahr 731 8 only only RB cord-028721-x6f26ahr 731 9 in in IN cord-028721-x6f26ahr 731 10 some some DT cord-028721-x6f26ahr 731 11 cases case NNS cord-028721-x6f26ahr 731 12 , , , cord-028721-x6f26ahr 731 13 whereas whereas IN cord-028721-x6f26ahr 731 14 LH lh NN cord-028721-x6f26ahr 731 15 and and CC cord-028721-x6f26ahr 731 16 testosterone testosterone NN cord-028721-x6f26ahr 731 17 are be VBP cord-028721-x6f26ahr 731 18 normal normal JJ cord-028721-x6f26ahr 731 19 . . . cord-028721-x6f26ahr 732 1 Adult adult NN cord-028721-x6f26ahr 732 2 testes testis NNS cord-028721-x6f26ahr 732 3 are be VBP cord-028721-x6f26ahr 732 4 small small JJ cord-028721-x6f26ahr 732 5 , , , cord-028721-x6f26ahr 732 6 with with IN cord-028721-x6f26ahr 732 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 732 8 tubules tubule NNS cord-028721-x6f26ahr 732 9 showing show VBG cord-028721-x6f26ahr 732 10 complete complete JJ cord-028721-x6f26ahr 732 11 but but CC cord-028721-x6f26ahr 732 12 diminished diminish VBD cord-028721-x6f26ahr 732 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 732 14 . . . cord-028721-x6f26ahr 733 1 Leydig leydig NN cord-028721-x6f26ahr 733 2 are be VBP cord-028721-x6f26ahr 733 3 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 733 4 . . . cord-028721-x6f26ahr 734 1 Unlike unlike IN cord-028721-x6f26ahr 734 2 patients patient NNS cord-028721-x6f26ahr 734 3 with with IN cord-028721-x6f26ahr 734 4 the the DT cord-028721-x6f26ahr 734 5 rudimentary rudimentary JJ cord-028721-x6f26ahr 734 6 testes testis NNS cord-028721-x6f26ahr 734 7 syndrome syndrome NN cord-028721-x6f26ahr 734 8 , , , cord-028721-x6f26ahr 734 9 microorchidism microorchidism NN cord-028721-x6f26ahr 734 10 patients patient NNS cord-028721-x6f26ahr 734 11 have have VBP cord-028721-x6f26ahr 734 12 a a DT cord-028721-x6f26ahr 734 13 normal normal JJ cord-028721-x6f26ahr 734 14 - - HYPH cord-028721-x6f26ahr 734 15 sized sized JJ cord-028721-x6f26ahr 734 16 penis penis NN cord-028721-x6f26ahr 734 17 and and CC cord-028721-x6f26ahr 734 18 no no DT cord-028721-x6f26ahr 734 19 epididymal epididymal JJ cord-028721-x6f26ahr 734 20 or or CC cord-028721-x6f26ahr 734 21 prostatic prostatic JJ cord-028721-x6f26ahr 734 22 atrophy atrophy NN cord-028721-x6f26ahr 734 23 . . . cord-028721-x6f26ahr 735 1 282 282 CD cord-028721-x6f26ahr 735 2 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 735 3 is be VBZ cord-028721-x6f26ahr 735 4 a a DT cord-028721-x6f26ahr 735 5 rare rare JJ cord-028721-x6f26ahr 735 6 condition condition NN cord-028721-x6f26ahr 735 7 , , , cord-028721-x6f26ahr 735 8 with with IN cord-028721-x6f26ahr 735 9 approximately approximately RB cord-028721-x6f26ahr 735 10 100 100 CD cord-028721-x6f26ahr 735 11 reported report VBN cord-028721-x6f26ahr 735 12 cases case NNS cord-028721-x6f26ahr 735 13 . . . cord-028721-x6f26ahr 736 1 283 283 CD cord-028721-x6f26ahr 736 2 , , , cord-028721-x6f26ahr 736 3 284 284 CD cord-028721-x6f26ahr 737 1 It -PRON- PRP cord-028721-x6f26ahr 737 2 was be VBD cord-028721-x6f26ahr 737 3 fi fi NNP cord-028721-x6f26ahr 737 4 rst rst NNP cord-028721-x6f26ahr 737 5 described describe VBN cord-028721-x6f26ahr 737 6 in in IN cord-028721-x6f26ahr 737 7 a a DT cord-028721-x6f26ahr 737 8 postmortem postmortem JJ cord-028721-x6f26ahr 737 9 study study NN cord-028721-x6f26ahr 737 10 in in IN cord-028721-x6f26ahr 737 11 1880 1880 CD cord-028721-x6f26ahr 737 12 , , , cord-028721-x6f26ahr 737 13 285 285 CD cord-028721-x6f26ahr 737 14 and and CC cord-028721-x6f26ahr 737 15 the the DT cord-028721-x6f26ahr 737 16 fi fi NN cord-028721-x6f26ahr 737 17 rst rst NN cord-028721-x6f26ahr 737 18 case case NN cord-028721-x6f26ahr 737 19 treated treat VBN cord-028721-x6f26ahr 737 20 surgically surgically RB cord-028721-x6f26ahr 737 21 and and CC cord-028721-x6f26ahr 737 22 confi confi NNP cord-028721-x6f26ahr 737 23 rmed rmed NNP cord-028721-x6f26ahr 737 24 histologically histologically RB cord-028721-x6f26ahr 737 25 was be VBD cord-028721-x6f26ahr 737 26 reported report VBN cord-028721-x6f26ahr 737 27 in in IN cord-028721-x6f26ahr 737 28 1895 1895 CD cord-028721-x6f26ahr 737 29 . . . cord-028721-x6f26ahr 738 1 286 286 CD cord-028721-x6f26ahr 739 1 Although although IN cord-028721-x6f26ahr 739 2 three three CD cord-028721-x6f26ahr 739 3 testes testis NNS cord-028721-x6f26ahr 739 4 are be VBP cord-028721-x6f26ahr 739 5 the the DT cord-028721-x6f26ahr 739 6 most most RBS cord-028721-x6f26ahr 739 7 common common JJ cord-028721-x6f26ahr 739 8 , , , cord-028721-x6f26ahr 739 9 287 287 CD cord-028721-x6f26ahr 739 10 four four CD cord-028721-x6f26ahr 739 11 testes testis NNS cord-028721-x6f26ahr 739 12 have have VBP cord-028721-x6f26ahr 739 13 been be VBN cord-028721-x6f26ahr 739 14 reported report VBN cord-028721-x6f26ahr 739 15 in in IN cord-028721-x6f26ahr 739 16 six six CD cord-028721-x6f26ahr 739 17 patients patient NNS cord-028721-x6f26ahr 739 18 , , , cord-028721-x6f26ahr 739 19 [ [ -LRB- cord-028721-x6f26ahr 739 20 288 288 CD cord-028721-x6f26ahr 739 21 ] ] -RRB- cord-028721-x6f26ahr 739 22 [ [ -LRB- cord-028721-x6f26ahr 739 23 289 289 CD cord-028721-x6f26ahr 739 24 ] ] -RRB- cord-028721-x6f26ahr 739 25 [ [ -LRB- cord-028721-x6f26ahr 739 26 290 290 CD cord-028721-x6f26ahr 739 27 ] ] -RRB- cord-028721-x6f26ahr 739 28 [ [ -LRB- cord-028721-x6f26ahr 739 29 291 291 CD cord-028721-x6f26ahr 739 30 ] ] -RRB- cord-028721-x6f26ahr 739 31 [ [ -LRB- cord-028721-x6f26ahr 739 32 292 292 CD cord-028721-x6f26ahr 739 33 ] ] -RRB- cord-028721-x6f26ahr 739 34 and and CC cord-028721-x6f26ahr 739 35 fi fi NNP cord-028721-x6f26ahr 739 36 ve ve VBD cord-028721-x6f26ahr 739 37 in in IN cord-028721-x6f26ahr 739 38 one one CD cord-028721-x6f26ahr 739 39 case case NN cord-028721-x6f26ahr 739 40 but but CC cord-028721-x6f26ahr 739 41 without without IN cord-028721-x6f26ahr 739 42 histologic histologic JJ cord-028721-x6f26ahr 739 43 confi confi NN cord-028721-x6f26ahr 739 44 rmation rmation NN cord-028721-x6f26ahr 739 45 . . . cord-028721-x6f26ahr 740 1 293 293 CD cord-028721-x6f26ahr 740 2 Age age NN cord-028721-x6f26ahr 740 3 of of IN cord-028721-x6f26ahr 740 4 diagnosis diagnosis NN cord-028721-x6f26ahr 740 5 varies vary VBZ cord-028721-x6f26ahr 740 6 from from IN cord-028721-x6f26ahr 740 7 newborn newborn JJ cord-028721-x6f26ahr 740 8 to to IN cord-028721-x6f26ahr 740 9 74 74 CD cord-028721-x6f26ahr 740 10 years year NNS cord-028721-x6f26ahr 740 11 , , , cord-028721-x6f26ahr 740 12 with with IN cord-028721-x6f26ahr 740 13 a a DT cord-028721-x6f26ahr 740 14 mean mean NN cord-028721-x6f26ahr 740 15 of of IN cord-028721-x6f26ahr 740 16 17 17 CD cord-028721-x6f26ahr 740 17 years year NNS cord-028721-x6f26ahr 740 18 . . . cord-028721-x6f26ahr 741 1 Testicular testicular JJ cord-028721-x6f26ahr 741 2 duplication duplication NN cord-028721-x6f26ahr 741 3 is be VBZ cord-028721-x6f26ahr 741 4 usually usually RB cord-028721-x6f26ahr 741 5 an an DT cord-028721-x6f26ahr 741 6 incidental incidental JJ cord-028721-x6f26ahr 741 7 fi fi NN cord-028721-x6f26ahr 741 8 nding nding NN cord-028721-x6f26ahr 741 9 during during IN cord-028721-x6f26ahr 741 10 surgery surgery NN cord-028721-x6f26ahr 741 11 for for IN cord-028721-x6f26ahr 741 12 inguinal inguinal JJ cord-028721-x6f26ahr 741 13 hernia hernia NN cord-028721-x6f26ahr 741 14 , , , cord-028721-x6f26ahr 741 15 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 741 16 , , , cord-028721-x6f26ahr 741 17 or or CC cord-028721-x6f26ahr 741 18 testicular testicular JJ cord-028721-x6f26ahr 741 19 torsion torsion NN cord-028721-x6f26ahr 741 20 , , , cord-028721-x6f26ahr 741 21 but but CC cord-028721-x6f26ahr 741 22 has have VBZ cord-028721-x6f26ahr 741 23 also also RB cord-028721-x6f26ahr 741 24 been be VBN cord-028721-x6f26ahr 741 25 detected detect VBN cord-028721-x6f26ahr 741 26 in in IN cord-028721-x6f26ahr 741 27 patients patient NNS cord-028721-x6f26ahr 741 28 with with IN cord-028721-x6f26ahr 741 29 infertility infertility NN cord-028721-x6f26ahr 741 30 or or CC cord-028721-x6f26ahr 741 31 unexplained unexplained JJ cord-028721-x6f26ahr 741 32 fertility fertility NN cord-028721-x6f26ahr 741 33 after after IN cord-028721-x6f26ahr 741 34 bilateral bilateral JJ cord-028721-x6f26ahr 741 35 vasectomy vasectomy NN cord-028721-x6f26ahr 741 36 . . . cord-028721-x6f26ahr 742 1 294 294 CD cord-028721-x6f26ahr 743 1 The the DT cord-028721-x6f26ahr 743 2 extra extra JJ cord-028721-x6f26ahr 743 3 testis testis NN cord-028721-x6f26ahr 743 4 is be VBZ cord-028721-x6f26ahr 743 5 often often RB cord-028721-x6f26ahr 743 6 intrascrotal intrascrotal JJ cord-028721-x6f26ahr 743 7 ( ( -LRB- cord-028721-x6f26ahr 743 8 75 75 CD cord-028721-x6f26ahr 743 9 % % NN cord-028721-x6f26ahr 743 10 ) ) -RRB- cord-028721-x6f26ahr 743 11 and and CC cord-028721-x6f26ahr 743 12 less less RBR cord-028721-x6f26ahr 743 13 frequently frequently RB cord-028721-x6f26ahr 743 14 inguinal inguinal JJ cord-028721-x6f26ahr 743 15 ( ( -LRB- cord-028721-x6f26ahr 743 16 20 20 CD cord-028721-x6f26ahr 743 17 % % NN cord-028721-x6f26ahr 743 18 ) ) -RRB- cord-028721-x6f26ahr 743 19 , , , cord-028721-x6f26ahr 743 20 abdominal abdominal JJ cord-028721-x6f26ahr 743 21 , , , cord-028721-x6f26ahr 743 22 295 295 CD cord-028721-x6f26ahr 743 23 or or CC cord-028721-x6f26ahr 743 24 retroperitoneal retroperitoneal JJ cord-028721-x6f26ahr 743 25 ( ( -LRB- cord-028721-x6f26ahr 743 26 5 5 CD cord-028721-x6f26ahr 743 27 % % NN cord-028721-x6f26ahr 743 28 ) ) -RRB- cord-028721-x6f26ahr 743 29 . . . cord-028721-x6f26ahr 744 1 296 296 CD cord-028721-x6f26ahr 744 2 , , , cord-028721-x6f26ahr 744 3 297 297 CD cord-028721-x6f26ahr 744 4 Duplication duplication NN cord-028721-x6f26ahr 744 5 is be VBZ cord-028721-x6f26ahr 744 6 three three CD cord-028721-x6f26ahr 744 7 times time NNS cord-028721-x6f26ahr 744 8 more more RBR cord-028721-x6f26ahr 744 9 frequent frequent JJ cord-028721-x6f26ahr 744 10 on on IN cord-028721-x6f26ahr 744 11 the the DT cord-028721-x6f26ahr 744 12 left left NN cord-028721-x6f26ahr 744 13 than than IN cord-028721-x6f26ahr 744 14 on on IN cord-028721-x6f26ahr 744 15 the the DT cord-028721-x6f26ahr 744 16 right right NN cord-028721-x6f26ahr 744 17 . . . cord-028721-x6f26ahr 745 1 298 298 CD cord-028721-x6f26ahr 745 2 High high JJ cord-028721-x6f26ahr 745 3 - - HYPH cord-028721-x6f26ahr 745 4 resolution resolution NN cord-028721-x6f26ahr 745 5 ultrasound ultrasound NN cord-028721-x6f26ahr 745 6 is be VBZ cord-028721-x6f26ahr 745 7 the the DT cord-028721-x6f26ahr 745 8 appropriate appropriate JJ cord-028721-x6f26ahr 745 9 diagnostic diagnostic JJ cord-028721-x6f26ahr 745 10 technique technique NN cord-028721-x6f26ahr 745 11 . . . cord-028721-x6f26ahr 746 1 284 284 CD cord-028721-x6f26ahr 746 2 , , , cord-028721-x6f26ahr 746 3 299 299 CD cord-028721-x6f26ahr 746 4 Testicular testicular JJ cord-028721-x6f26ahr 746 5 maldescent maldescent NN cord-028721-x6f26ahr 746 6 ( ( -LRB- cord-028721-x6f26ahr 746 7 40 40 CD cord-028721-x6f26ahr 746 8 % % NN cord-028721-x6f26ahr 746 9 ) ) -RRB- cord-028721-x6f26ahr 746 10 , , , cord-028721-x6f26ahr 746 11 inguinal inguinal JJ cord-028721-x6f26ahr 746 12 hernia hernia NN cord-028721-x6f26ahr 746 13 ( ( -LRB- cord-028721-x6f26ahr 746 14 30 30 CD cord-028721-x6f26ahr 746 15 % % NN cord-028721-x6f26ahr 746 16 ) ) -RRB- cord-028721-x6f26ahr 746 17 , , , cord-028721-x6f26ahr 746 18 hydrocele hydrocele NN cord-028721-x6f26ahr 746 19 , , , cord-028721-x6f26ahr 746 20 varicocele varicocele NN cord-028721-x6f26ahr 746 21 , , , cord-028721-x6f26ahr 746 22 and and CC cord-028721-x6f26ahr 746 23 contralateral contralateral JJ cord-028721-x6f26ahr 746 24 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 746 25 are be VBP cord-028721-x6f26ahr 746 26 the the DT cord-028721-x6f26ahr 746 27 most most RBS cord-028721-x6f26ahr 746 28 frequently frequently RB cord-028721-x6f26ahr 746 29 associated associate VBN cord-028721-x6f26ahr 746 30 anomalies anomaly NNS cord-028721-x6f26ahr 746 31 . . . cord-028721-x6f26ahr 747 1 [ [ -LRB- cord-028721-x6f26ahr 747 2 300 300 CD cord-028721-x6f26ahr 747 3 ] ] -RRB- cord-028721-x6f26ahr 747 4 [ [ -LRB- cord-028721-x6f26ahr 747 5 301 301 CD cord-028721-x6f26ahr 747 6 ] ] -RRB- cord-028721-x6f26ahr 747 7 [ [ -LRB- cord-028721-x6f26ahr 747 8 302 302 CD cord-028721-x6f26ahr 747 9 ] ] -RRB- cord-028721-x6f26ahr 747 10 Testicular testicular JJ cord-028721-x6f26ahr 747 11 torsion torsion NN cord-028721-x6f26ahr 747 12 ( ( -LRB- cord-028721-x6f26ahr 747 13 13 13 CD cord-028721-x6f26ahr 747 14 % % NN cord-028721-x6f26ahr 747 15 ) ) -RRB- cord-028721-x6f26ahr 747 16 303 303 CD cord-028721-x6f26ahr 747 17 and and CC cord-028721-x6f26ahr 747 18 testicular testicular JJ cord-028721-x6f26ahr 747 19 cancer cancer NN cord-028721-x6f26ahr 747 20 ( ( -LRB- cord-028721-x6f26ahr 747 21 5.4 5.4 CD cord-028721-x6f26ahr 747 22 % % NN cord-028721-x6f26ahr 747 23 ) ) -RRB- cord-028721-x6f26ahr 747 24 are be VBP cord-028721-x6f26ahr 747 25 occasional occasional JJ cord-028721-x6f26ahr 747 26 complications complication NNS cord-028721-x6f26ahr 747 27 . . . cord-028721-x6f26ahr 748 1 Although although IN cord-028721-x6f26ahr 748 2 the the DT cord-028721-x6f26ahr 748 3 extra extra JJ cord-028721-x6f26ahr 748 4 testis testis NN cord-028721-x6f26ahr 748 5 may may MD cord-028721-x6f26ahr 748 6 be be VB cord-028721-x6f26ahr 748 7 histologically histologically RB cord-028721-x6f26ahr 748 8 normal normal JJ cord-028721-x6f26ahr 748 9 , , , cord-028721-x6f26ahr 748 10 304 304 CD cord-028721-x6f26ahr 748 11 - - SYM cord-028721-x6f26ahr 748 12 306 306 CD cord-028721-x6f26ahr 748 13 usually usually RB cord-028721-x6f26ahr 748 14 it -PRON- PRP cord-028721-x6f26ahr 748 15 is be VBZ cord-028721-x6f26ahr 748 16 not not RB cord-028721-x6f26ahr 748 17 , , , cord-028721-x6f26ahr 748 18 300 300 CD cord-028721-x6f26ahr 748 19 , , , cord-028721-x6f26ahr 748 20 307 307 CD cord-028721-x6f26ahr 748 21 and and CC cord-028721-x6f26ahr 748 22 displays display VBZ cord-028721-x6f26ahr 748 23 lesions lesion NNS cord-028721-x6f26ahr 748 24 such such JJ cord-028721-x6f26ahr 748 25 as as IN cord-028721-x6f26ahr 748 26 Sertoli sertoli JJ cord-028721-x6f26ahr 748 27 cell cell NN cord-028721-x6f26ahr 748 28 - - HYPH cord-028721-x6f26ahr 748 29 only only RB cord-028721-x6f26ahr 748 30 tubules tubule NNS cord-028721-x6f26ahr 748 31 , , , cord-028721-x6f26ahr 748 32 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 748 33 , , , cord-028721-x6f26ahr 748 34 or or CC cord-028721-x6f26ahr 748 35 maturation maturation NN cord-028721-x6f26ahr 748 36 arrest arrest NN cord-028721-x6f26ahr 748 37 . . . cord-028721-x6f26ahr 749 1 The the DT cord-028721-x6f26ahr 749 2 lack lack NN cord-028721-x6f26ahr 749 3 of of IN cord-028721-x6f26ahr 749 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 749 5 has have VBZ cord-028721-x6f26ahr 749 6 been be VBN cord-028721-x6f26ahr 749 7 attributed attribute VBN cord-028721-x6f26ahr 749 8 to to IN cord-028721-x6f26ahr 749 9 the the DT cord-028721-x6f26ahr 749 10 anomalous anomalous JJ cord-028721-x6f26ahr 749 11 location location NN cord-028721-x6f26ahr 749 12 of of IN cord-028721-x6f26ahr 749 13 the the DT cord-028721-x6f26ahr 749 14 testis testis NN cord-028721-x6f26ahr 749 15 and and CC cord-028721-x6f26ahr 749 16 the the DT cord-028721-x6f26ahr 749 17 absence absence NN cord-028721-x6f26ahr 749 18 of of IN cord-028721-x6f26ahr 749 19 communication communication NN cord-028721-x6f26ahr 749 20 between between IN cord-028721-x6f26ahr 749 21 the the DT cord-028721-x6f26ahr 749 22 testis testis NN cord-028721-x6f26ahr 749 23 and and CC cord-028721-x6f26ahr 749 24 excretory excretory JJ cord-028721-x6f26ahr 749 25 ducts duct NNS cord-028721-x6f26ahr 749 26 . . . cord-028721-x6f26ahr 750 1 308 308 CD cord-028721-x6f26ahr 751 1 The the DT cord-028721-x6f26ahr 751 2 embryologic embryologic JJ cord-028721-x6f26ahr 751 3 origin origin NN cord-028721-x6f26ahr 751 4 of of IN cord-028721-x6f26ahr 751 5 polyorchidism polyorchidism NN cord-028721-x6f26ahr 751 6 remains remain VBZ cord-028721-x6f26ahr 751 7 uncertain uncertain JJ cord-028721-x6f26ahr 751 8 , , , cord-028721-x6f26ahr 751 9 and and CC cord-028721-x6f26ahr 751 10 the the DT cord-028721-x6f26ahr 751 11 following follow VBG cord-028721-x6f26ahr 751 12 have have VBP cord-028721-x6f26ahr 751 13 been be VBN cord-028721-x6f26ahr 751 14 proposed propose VBN cord-028721-x6f26ahr 751 15 to to TO cord-028721-x6f26ahr 751 16 account account VB cord-028721-x6f26ahr 751 17 for for IN cord-028721-x6f26ahr 751 18 the the DT cord-028721-x6f26ahr 751 19 variety variety NN cord-028721-x6f26ahr 751 20 of of IN cord-028721-x6f26ahr 751 21 fi fi NNP cord-028721-x6f26ahr 751 22 ndings nding NNS cord-028721-x6f26ahr 751 23 in in IN cord-028721-x6f26ahr 751 24 different different JJ cord-028721-x6f26ahr 751 25 cases case NNS cord-028721-x6f26ahr 752 1 ( ( -LRB- cord-028721-x6f26ahr 752 2 Fig Fig NNP cord-028721-x6f26ahr 752 3 . . . cord-028721-x6f26ahr 752 4 12 12 CD cord-028721-x6f26ahr 752 5 - - SYM cord-028721-x6f26ahr 752 6 28 28 CD cord-028721-x6f26ahr 752 7 The the DT cord-028721-x6f26ahr 752 8 clinical clinical JJ cord-028721-x6f26ahr 752 9 differential differential JJ cord-028721-x6f26ahr 752 10 diagnosis diagnosis NN cord-028721-x6f26ahr 752 11 of of IN cord-028721-x6f26ahr 752 12 polyorchidism polyorchidism NN cord-028721-x6f26ahr 752 13 includes include VBZ cord-028721-x6f26ahr 752 14 most most JJS cord-028721-x6f26ahr 752 15 of of IN cord-028721-x6f26ahr 752 16 pathologic pathologic JJ cord-028721-x6f26ahr 752 17 conditions condition NNS cord-028721-x6f26ahr 752 18 that that WDT cord-028721-x6f26ahr 752 19 enlarge enlarge VBP cord-028721-x6f26ahr 752 20 the the DT cord-028721-x6f26ahr 752 21 scrotum scrotum NN cord-028721-x6f26ahr 752 22 and and CC cord-028721-x6f26ahr 752 23 spermatic spermatic JJ cord-028721-x6f26ahr 752 24 cords cord NNS cord-028721-x6f26ahr 752 25 : : : cord-028721-x6f26ahr 752 26 spermatocele spermatocele NNP cord-028721-x6f26ahr 752 27 , , , cord-028721-x6f26ahr 752 28 hydrocele hydrocele NNP cord-028721-x6f26ahr 752 29 , , , cord-028721-x6f26ahr 752 30 cysts cyst NNS cord-028721-x6f26ahr 752 31 and and CC cord-028721-x6f26ahr 752 32 tumors tumor NNS cord-028721-x6f26ahr 752 33 of of IN cord-028721-x6f26ahr 752 34 the the DT cord-028721-x6f26ahr 752 35 spermatic spermatic JJ cord-028721-x6f26ahr 752 36 cord cord NN cord-028721-x6f26ahr 752 37 , , , cord-028721-x6f26ahr 752 38 crossed cross VBD cord-028721-x6f26ahr 752 39 testicular testicular NN cord-028721-x6f26ahr 752 40 ectopia ectopia NN cord-028721-x6f26ahr 752 41 , , , cord-028721-x6f26ahr 752 42 adrenal adrenal JJ cord-028721-x6f26ahr 752 43 cortical cortical JJ cord-028721-x6f26ahr 752 44 ectopia ectopia NN cord-028721-x6f26ahr 752 45 , , , cord-028721-x6f26ahr 752 46 and and CC cord-028721-x6f26ahr 752 47 splenogonadal splenogonadal JJ cord-028721-x6f26ahr 752 48 fusion fusion NN cord-028721-x6f26ahr 752 49 . . . cord-028721-x6f26ahr 753 1 Orchidectomy Orchidectomy NNP cord-028721-x6f26ahr 753 2 used use VBD cord-028721-x6f26ahr 753 3 to to TO cord-028721-x6f26ahr 753 4 be be VB cord-028721-x6f26ahr 753 5 the the DT cord-028721-x6f26ahr 753 6 treatment treatment NN cord-028721-x6f26ahr 753 7 of of IN cord-028721-x6f26ahr 753 8 choice choice NN cord-028721-x6f26ahr 753 9 for for IN cord-028721-x6f26ahr 753 10 all all DT cord-028721-x6f26ahr 753 11 atrophic atrophic JJ cord-028721-x6f26ahr 753 12 and and CC cord-028721-x6f26ahr 753 13 non non JJ cord-028721-x6f26ahr 753 14 - - JJ cord-028721-x6f26ahr 753 15 scrotal scrotal JJ cord-028721-x6f26ahr 753 16 testes testis NNS cord-028721-x6f26ahr 753 17 . . . cord-028721-x6f26ahr 754 1 Today today NN cord-028721-x6f26ahr 754 2 , , , cord-028721-x6f26ahr 754 3 most most JJS cord-028721-x6f26ahr 754 4 surgeons surgeon NNS cord-028721-x6f26ahr 754 5 undertake undertake VBP cord-028721-x6f26ahr 754 6 fi fi NN cord-028721-x6f26ahr 754 7 xation xation NN cord-028721-x6f26ahr 754 8 of of IN cord-028721-x6f26ahr 754 9 the the DT cord-028721-x6f26ahr 754 10 testis testis NN cord-028721-x6f26ahr 754 11 to to IN cord-028721-x6f26ahr 754 12 the the DT cord-028721-x6f26ahr 754 13 scrotal scrotal JJ cord-028721-x6f26ahr 754 14 pouch pouch NN cord-028721-x6f26ahr 754 15 and and CC cord-028721-x6f26ahr 754 16 the the DT cord-028721-x6f26ahr 754 17 re re NN cord-028721-x6f26ahr 754 18 - - NN cord-028721-x6f26ahr 754 19 creation creation NN cord-028721-x6f26ahr 754 20 of of IN cord-028721-x6f26ahr 754 21 a a DT cord-028721-x6f26ahr 754 22 ' ' `` cord-028721-x6f26ahr 754 23 simple simple JJ cord-028721-x6f26ahr 754 24 testis testis NN cord-028721-x6f26ahr 754 25 ' ' '' cord-028721-x6f26ahr 754 26 if if IN cord-028721-x6f26ahr 754 27 it -PRON- PRP cord-028721-x6f26ahr 754 28 is be VBZ cord-028721-x6f26ahr 754 29 permitted permit VBN cord-028721-x6f26ahr 754 30 by by IN cord-028721-x6f26ahr 754 31 the the DT cord-028721-x6f26ahr 754 32 anatomical anatomical JJ cord-028721-x6f26ahr 754 33 condition condition NN cord-028721-x6f26ahr 754 34 and and CC cord-028721-x6f26ahr 754 35 malignancy malignancy NN cord-028721-x6f26ahr 754 36 has have VBZ cord-028721-x6f26ahr 754 37 been be VBN cord-028721-x6f26ahr 754 38 precluded preclude VBN cord-028721-x6f26ahr 754 39 . . . cord-028721-x6f26ahr 755 1 This this DT cord-028721-x6f26ahr 755 2 treatment treatment NN cord-028721-x6f26ahr 755 3 may may MD cord-028721-x6f26ahr 755 4 allow allow VB cord-028721-x6f26ahr 755 5 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 755 6 as as RB cord-028721-x6f26ahr 755 7 well well RB cord-028721-x6f26ahr 755 8 as as IN cord-028721-x6f26ahr 755 9 additional additional JJ cord-028721-x6f26ahr 755 10 psychologic psychologic JJ cord-028721-x6f26ahr 755 11 and and CC cord-028721-x6f26ahr 755 12 cosmetic cosmetic JJ cord-028721-x6f26ahr 755 13 benefi benefi NN cord-028721-x6f26ahr 755 14 ts ts NN cord-028721-x6f26ahr 755 15 . . . cord-028721-x6f26ahr 756 1 313 313 CD cord-028721-x6f26ahr 757 1 Intrascrotal Intrascrotal NNP cord-028721-x6f26ahr 757 2 rhabdomyosarcoma rhabdomyosarcoma NNP cord-028721-x6f26ahr 757 3 , , , cord-028721-x6f26ahr 757 4 testicular testicular JJ cord-028721-x6f26ahr 757 5 teratoma teratoma NN cord-028721-x6f26ahr 757 6 , , , cord-028721-x6f26ahr 757 7 and and CC cord-028721-x6f26ahr 757 8 seminoma seminoma NN cord-028721-x6f26ahr 757 9 have have VBP cord-028721-x6f26ahr 757 10 been be VBN cord-028721-x6f26ahr 757 11 reported report VBN cord-028721-x6f26ahr 757 12 in in IN cord-028721-x6f26ahr 757 13 patients patient NNS cord-028721-x6f26ahr 757 14 with with IN cord-028721-x6f26ahr 757 15 polyorchidism polyorchidism NN cord-028721-x6f26ahr 757 16 . . . cord-028721-x6f26ahr 758 1 314 314 CD cord-028721-x6f26ahr 758 2 , , , cord-028721-x6f26ahr 758 3 315 315 CD cord-028721-x6f26ahr 758 4 _SP cord-028721-x6f26ahr 758 5 Macro Macro NNP cord-028721-x6f26ahr 758 6 - - HYPH cord-028721-x6f26ahr 758 7 orchidism orchidism NN cord-028721-x6f26ahr 758 8 may may MD cord-028721-x6f26ahr 758 9 be be VB cord-028721-x6f26ahr 758 10 uni uni NN cord-028721-x6f26ahr 758 11 - - HYPH cord-028721-x6f26ahr 758 12 or or CC cord-028721-x6f26ahr 758 13 bilateral bilateral JJ cord-028721-x6f26ahr 758 14 and and CC cord-028721-x6f26ahr 758 15 be be VB cord-028721-x6f26ahr 758 16 associated associate VBN cord-028721-x6f26ahr 758 17 with with IN cord-028721-x6f26ahr 758 18 chromosomal chromosomal JJ cord-028721-x6f26ahr 758 19 anomalies anomaly NNS cord-028721-x6f26ahr 758 20 or or CC cord-028721-x6f26ahr 758 21 endocrine endocrine JJ cord-028721-x6f26ahr 758 22 alterations alteration NNS cord-028721-x6f26ahr 758 23 . . . cord-028721-x6f26ahr 759 1 An an DT cord-028721-x6f26ahr 759 2 increase increase NN cord-028721-x6f26ahr 759 3 in in IN cord-028721-x6f26ahr 759 4 the the DT cord-028721-x6f26ahr 759 5 testicular testicular JJ cord-028721-x6f26ahr 759 6 parenchyma parenchyma NN cord-028721-x6f26ahr 759 7 occurs occur VBZ cord-028721-x6f26ahr 759 8 in in IN cord-028721-x6f26ahr 759 9 several several JJ cord-028721-x6f26ahr 759 10 conditions condition NNS cord-028721-x6f26ahr 759 11 , , , cord-028721-x6f26ahr 759 12 316 316 CD cord-028721-x6f26ahr 759 13 including include VBG cord-028721-x6f26ahr 759 14 congenital congenital JJ cord-028721-x6f26ahr 759 15 Leydig Leydig NNP cord-028721-x6f26ahr 759 16 cell cell NN cord-028721-x6f26ahr 759 17 hyperplasia hyperplasia NN cord-028721-x6f26ahr 759 18 , , , cord-028721-x6f26ahr 759 19 compensatory compensatory JJ cord-028721-x6f26ahr 759 20 hypertrophy hypertrophy NN cord-028721-x6f26ahr 759 21 , , , cord-028721-x6f26ahr 759 22 benign benign JJ cord-028721-x6f26ahr 759 23 idiopathic idiopathic JJ cord-028721-x6f26ahr 759 24 macroorchidism macroorchidism NN cord-028721-x6f26ahr 759 25 , , , cord-028721-x6f26ahr 759 26 bilateral bilateral JJ cord-028721-x6f26ahr 759 27 megalotestes megaloteste NNS cord-028721-x6f26ahr 759 28 with with IN cord-028721-x6f26ahr 759 29 low low JJ cord-028721-x6f26ahr 759 30 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 759 31 , , , cord-028721-x6f26ahr 759 32 fragile fragile JJ cord-028721-x6f26ahr 759 33 X x NN cord-028721-x6f26ahr 759 34 chromosome chromosome NN cord-028721-x6f26ahr 759 35 , , , cord-028721-x6f26ahr 759 36 and and CC cord-028721-x6f26ahr 759 37 the the DT cord-028721-x6f26ahr 759 38 testicular testicular JJ cord-028721-x6f26ahr 759 39 hypertrophy hypertrophy NN cord-028721-x6f26ahr 759 40 observed observe VBN cord-028721-x6f26ahr 759 41 in in IN cord-028721-x6f26ahr 759 42 juvenile juvenile JJ cord-028721-x6f26ahr 759 43 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 759 44 . . . cord-028721-x6f26ahr 760 1 Congenital congenital JJ cord-028721-x6f26ahr 760 2 Leydig Leydig NNP cord-028721-x6f26ahr 760 3 cell cell NN cord-028721-x6f26ahr 760 4 hyperplasia hyperplasia NN cord-028721-x6f26ahr 760 5 is be VBZ cord-028721-x6f26ahr 760 6 uncommon uncommon JJ cord-028721-x6f26ahr 760 7 and and CC cord-028721-x6f26ahr 760 8 may may MD cord-028721-x6f26ahr 760 9 be be VB cord-028721-x6f26ahr 760 10 diffuse diffuse JJ cord-028721-x6f26ahr 760 11 or or CC cord-028721-x6f26ahr 760 12 nodular nodular JJ cord-028721-x6f26ahr 760 13 . . . cord-028721-x6f26ahr 761 1 The the DT cord-028721-x6f26ahr 761 2 diagnosis diagnosis NN cord-028721-x6f26ahr 761 3 of of IN cord-028721-x6f26ahr 761 4 diffuse diffuse JJ cord-028721-x6f26ahr 761 5 Leydig Leydig NNP cord-028721-x6f26ahr 761 6 cell cell NN cord-028721-x6f26ahr 761 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 761 8 requires require VBZ cord-028721-x6f26ahr 761 9 quantifi quantifi NNP cord-028721-x6f26ahr 761 10 cation cation NN cord-028721-x6f26ahr 761 11 of of IN cord-028721-x6f26ahr 761 12 Leydig Leydig NNP cord-028721-x6f26ahr 761 13 cells cell NNS cord-028721-x6f26ahr 761 14 by by IN cord-028721-x6f26ahr 761 15 morphometry morphometry NNP cord-028721-x6f26ahr 761 16 , , , cord-028721-x6f26ahr 761 17 using use VBG cord-028721-x6f26ahr 761 18 normal normal JJ cord-028721-x6f26ahr 761 19 newborn newborn JJ cord-028721-x6f26ahr 761 20 testes testis NNS cord-028721-x6f26ahr 761 21 as as IN cord-028721-x6f26ahr 761 22 controls control NNS cord-028721-x6f26ahr 761 23 ( ( -LRB- cord-028721-x6f26ahr 761 24 Fig Fig NNP cord-028721-x6f26ahr 761 25 . . . cord-028721-x6f26ahr 761 26 _SP cord-028721-x6f26ahr 762 1 12 12 CD cord-028721-x6f26ahr 762 2 - - SYM cord-028721-x6f26ahr 762 3 29 29 CD cord-028721-x6f26ahr 762 4 ) ) -RRB- cord-028721-x6f26ahr 762 5 . . . cord-028721-x6f26ahr 763 1 Nodular Nodular NNP cord-028721-x6f26ahr 763 2 Leydig Leydig NNP cord-028721-x6f26ahr 763 3 cell cell NN cord-028721-x6f26ahr 763 4 hyperplasia hyperplasia NN cord-028721-x6f26ahr 763 5 is be VBZ cord-028721-x6f26ahr 763 6 characterized characterize VBN cord-028721-x6f26ahr 763 7 by by IN cord-028721-x6f26ahr 763 8 the the DT cord-028721-x6f26ahr 763 9 presence presence NN cord-028721-x6f26ahr 763 10 of of IN cord-028721-x6f26ahr 763 11 non non JJ cord-028721-x6f26ahr 763 12 - - JJ cord-028721-x6f26ahr 763 13 encapsulated encapsulated JJ cord-028721-x6f26ahr 763 14 Leydig Leydig NNP cord-028721-x6f26ahr 763 15 cell cell NN cord-028721-x6f26ahr 763 16 nodules nodule NNS cord-028721-x6f26ahr 763 17 in in IN cord-028721-x6f26ahr 763 18 the the DT cord-028721-x6f26ahr 763 19 mediastinum mediastinum NN cord-028721-x6f26ahr 763 20 testis testis NN cord-028721-x6f26ahr 763 21 , , , cord-028721-x6f26ahr 763 22 adjacent adjacent JJ cord-028721-x6f26ahr 763 23 testicular testicular JJ cord-028721-x6f26ahr 763 24 parenchyma parenchyma NN cord-028721-x6f26ahr 763 25 and and CC cord-028721-x6f26ahr 763 26 connective connective JJ cord-028721-x6f26ahr 763 27 tissue tissue NN cord-028721-x6f26ahr 763 28 among among IN cord-028721-x6f26ahr 763 29 the the DT cord-028721-x6f26ahr 763 30 ductuli ductuli NNP cord-028721-x6f26ahr 763 31 efferentes efferentes NNP cord-028721-x6f26ahr 763 32 ( ( -LRB- cord-028721-x6f26ahr 763 33 Fig Fig NNP cord-028721-x6f26ahr 763 34 . . . cord-028721-x6f26ahr 763 35 12 12 CD cord-028721-x6f26ahr 763 36 - - SYM cord-028721-x6f26ahr 763 37 30 30 CD cord-028721-x6f26ahr 763 38 ) ) -RRB- cord-028721-x6f26ahr 763 39 . . . cord-028721-x6f26ahr 764 1 The the DT cord-028721-x6f26ahr 764 2 differential differential JJ cord-028721-x6f26ahr 764 3 diagnosis diagnosis NN cord-028721-x6f26ahr 764 4 of of IN cord-028721-x6f26ahr 764 5 nodular nodular JJ cord-028721-x6f26ahr 764 6 Leydig Leydig NNP cord-028721-x6f26ahr 764 7 cell cell NN cord-028721-x6f26ahr 764 8 hyperplasia hyperplasia NN cord-028721-x6f26ahr 764 9 includes include VBZ cord-028721-x6f26ahr 764 10 intratesticular intratesticular JJ cord-028721-x6f26ahr 764 11 adrenal adrenal JJ cord-028721-x6f26ahr 764 12 rests rest NNS cord-028721-x6f26ahr 764 13 and and CC cord-028721-x6f26ahr 764 14 bilateral bilateral JJ cord-028721-x6f26ahr 764 15 Leydig Leydig NNP cord-028721-x6f26ahr 764 16 cell cell NN cord-028721-x6f26ahr 764 17 tumor tumor NN cord-028721-x6f26ahr 764 18 . . . cord-028721-x6f26ahr 765 1 Except except IN cord-028721-x6f26ahr 765 2 for for IN cord-028721-x6f26ahr 765 3 patients patient NNS cord-028721-x6f26ahr 765 4 with with IN cord-028721-x6f26ahr 765 5 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 765 6 syndrome syndrome NN cord-028721-x6f26ahr 765 7 , , , cord-028721-x6f26ahr 765 8 intratesticular intratesticular JJ cord-028721-x6f26ahr 765 9 adrenal adrenal JJ cord-028721-x6f26ahr 765 10 rests rest NNS cord-028721-x6f26ahr 765 11 are be VBP cord-028721-x6f26ahr 765 12 rare rare JJ cord-028721-x6f26ahr 765 13 . . . cord-028721-x6f26ahr 766 1 These these DT cord-028721-x6f26ahr 766 2 rests rest NNS cord-028721-x6f26ahr 766 3 are be VBP cord-028721-x6f26ahr 766 4 encapsulated encapsulate VBN cord-028721-x6f26ahr 766 5 , , , cord-028721-x6f26ahr 766 6 with with IN cord-028721-x6f26ahr 766 7 the the DT cord-028721-x6f26ahr 766 8 exception exception NN cord-028721-x6f26ahr 766 9 of of IN cord-028721-x6f26ahr 766 10 the the DT cord-028721-x6f26ahr 766 11 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 766 12 tumors tumor NNS cord-028721-x6f26ahr 766 13 , , , cord-028721-x6f26ahr 766 14 and and CC cord-028721-x6f26ahr 766 15 consist consist VBP cord-028721-x6f26ahr 766 16 of of IN cord-028721-x6f26ahr 766 17 radially radially RB cord-028721-x6f26ahr 766 18 arranged arrange VBN cord-028721-x6f26ahr 766 19 cells cell NNS cord-028721-x6f26ahr 766 20 with with IN cord-028721-x6f26ahr 766 21 vesicular vesicular JJ cord-028721-x6f26ahr 766 22 nuclei nucleus NNS cord-028721-x6f26ahr 766 23 and and CC cord-028721-x6f26ahr 766 24 small small JJ cord-028721-x6f26ahr 766 25 nucleoli nucleolus NNS cord-028721-x6f26ahr 766 26 displacing displace VBG cord-028721-x6f26ahr 766 27 the the DT cord-028721-x6f26ahr 766 28 rete rete NNP cord-028721-x6f26ahr 766 29 testis testis NN cord-028721-x6f26ahr 766 30 or or CC cord-028721-x6f26ahr 766 31 seminiferous seminiferous JJ cord-028721-x6f26ahr 766 32 tubules tubule NNS cord-028721-x6f26ahr 766 33 . . . cord-028721-x6f26ahr 767 1 Leydig leydig NN cord-028721-x6f26ahr 767 2 cell cell NN cord-028721-x6f26ahr 767 3 tumors tumor NNS cord-028721-x6f26ahr 767 4 may may MD cord-028721-x6f26ahr 767 5 be be VB cord-028721-x6f26ahr 767 6 bilateral bilateral JJ cord-028721-x6f26ahr 767 7 , , , cord-028721-x6f26ahr 767 8 poorly poorly RB cord-028721-x6f26ahr 767 9 circumscribed circumscribed JJ cord-028721-x6f26ahr 767 10 , , , cord-028721-x6f26ahr 767 11 and and CC cord-028721-x6f26ahr 767 12 surrounded surround VBN cord-028721-x6f26ahr 767 13 by by IN cord-028721-x6f26ahr 767 14 testicular testicular JJ cord-028721-x6f26ahr 767 15 parenchyma parenchyma NNS cord-028721-x6f26ahr 767 16 , , , cord-028721-x6f26ahr 767 17 features feature VBZ cord-028721-x6f26ahr 767 18 making make VBG cord-028721-x6f26ahr 767 19 it -PRON- PRP cord-028721-x6f26ahr 767 20 diffi diffi JJ cord-028721-x6f26ahr 767 21 cult cult NN cord-028721-x6f26ahr 767 22 to to TO cord-028721-x6f26ahr 767 23 distinguish distinguish VB cord-028721-x6f26ahr 767 24 from from IN cord-028721-x6f26ahr 767 25 Leydig Leydig NNP cord-028721-x6f26ahr 767 26 cell cell NN cord-028721-x6f26ahr 767 27 hyper hyper NN cord-028721-x6f26ahr 767 28 - - JJ cord-028721-x6f26ahr 767 29 plasia plasia JJ cord-028721-x6f26ahr 767 30 . . . cord-028721-x6f26ahr 768 1 However however RB cord-028721-x6f26ahr 768 2 , , , cord-028721-x6f26ahr 768 3 Leydig leydig NN cord-028721-x6f26ahr 768 4 cell cell NN cord-028721-x6f26ahr 768 5 tumors tumor NNS cord-028721-x6f26ahr 768 6 are be VBP cord-028721-x6f26ahr 768 7 rarely rarely RB cord-028721-x6f26ahr 768 8 congenital congenital JJ cord-028721-x6f26ahr 768 9 , , , cord-028721-x6f26ahr 768 10 whereas whereas IN cord-028721-x6f26ahr 768 11 those those DT cord-028721-x6f26ahr 768 12 occurring occur VBG cord-028721-x6f26ahr 768 13 at at IN cord-028721-x6f26ahr 768 14 infancy infancy NN cord-028721-x6f26ahr 768 15 often often RB cord-028721-x6f26ahr 768 16 induce induce VBP cord-028721-x6f26ahr 768 17 precocious precocious JJ cord-028721-x6f26ahr 768 18 maturation maturation NN cord-028721-x6f26ahr 768 19 of of IN cord-028721-x6f26ahr 768 20 the the DT cord-028721-x6f26ahr 768 21 adjacent adjacent JJ cord-028721-x6f26ahr 768 22 seminiferous seminiferous JJ cord-028721-x6f26ahr 768 23 tubules tubule NNS cord-028721-x6f26ahr 768 24 and and CC cord-028721-x6f26ahr 768 25 early early JJ cord-028721-x6f26ahr 768 26 macrogenitosomia macrogenitosomia NN cord-028721-x6f26ahr 768 27 . . . cord-028721-x6f26ahr 769 1 Leydig leydig NN cord-028721-x6f26ahr 769 2 cell cell NN cord-028721-x6f26ahr 769 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 769 4 is be VBZ cord-028721-x6f26ahr 769 5 caused cause VBN cord-028721-x6f26ahr 769 6 by by IN cord-028721-x6f26ahr 769 7 large large JJ cord-028721-x6f26ahr 769 8 quantities quantity NNS cord-028721-x6f26ahr 769 9 of of IN cord-028721-x6f26ahr 769 10 hCG hcg NN cord-028721-x6f26ahr 769 11 entering enter VBG cord-028721-x6f26ahr 769 12 the the DT cord-028721-x6f26ahr 769 13 fetal fetal JJ cord-028721-x6f26ahr 769 14 circulation circulation NN cord-028721-x6f26ahr 769 15 . . . cord-028721-x6f26ahr 770 1 Diabetic diabetic JJ cord-028721-x6f26ahr 770 2 mothers mother NNS cord-028721-x6f26ahr 770 3 , , , cord-028721-x6f26ahr 770 4 particularly particularly RB cord-028721-x6f26ahr 770 5 those those DT cord-028721-x6f26ahr 770 6 with with IN cord-028721-x6f26ahr 770 7 hypertension hypertension NN cord-028721-x6f26ahr 770 8 , , , cord-028721-x6f26ahr 770 9 may may MD cord-028721-x6f26ahr 770 10 develop develop VB cord-028721-x6f26ahr 770 11 hyperplacentosis hyperplacentosis NN cord-028721-x6f26ahr 770 12 ; ; : cord-028721-x6f26ahr 770 13 the the DT cord-028721-x6f26ahr 770 14 resulting result VBG cord-028721-x6f26ahr 770 15 edema edema NN cord-028721-x6f26ahr 770 16 in in IN cord-028721-x6f26ahr 770 17 the the DT cord-028721-x6f26ahr 770 18 placental placental JJ cord-028721-x6f26ahr 770 19 villi villi NN cord-028721-x6f26ahr 770 20 alters alter VBZ cord-028721-x6f26ahr 770 21 the the DT cord-028721-x6f26ahr 770 22 vascular vascular JJ cord-028721-x6f26ahr 770 23 permeability permeability NN cord-028721-x6f26ahr 770 24 and and CC cord-028721-x6f26ahr 770 25 allows allow VBZ cord-028721-x6f26ahr 770 26 the the DT cord-028721-x6f26ahr 770 27 passage passage NN cord-028721-x6f26ahr 770 28 of of IN cord-028721-x6f26ahr 770 29 hCG hcg NN cord-028721-x6f26ahr 770 30 to to IN cord-028721-x6f26ahr 770 31 the the DT cord-028721-x6f26ahr 770 32 fetus fetus NN cord-028721-x6f26ahr 770 33 . . . cord-028721-x6f26ahr 771 1 Congenital congenital JJ cord-028721-x6f26ahr 771 2 Leydig Leydig NNP cord-028721-x6f26ahr 771 3 cell cell NN cord-028721-x6f26ahr 771 4 hyperplasia hyperplasia NN cord-028721-x6f26ahr 771 5 decreases decrease VBZ cord-028721-x6f26ahr 771 6 rapidly rapidly RB cord-028721-x6f26ahr 771 7 during during IN cord-028721-x6f26ahr 771 8 the the DT cord-028721-x6f26ahr 771 9 fi fi NNP cord-028721-x6f26ahr 771 10 rst rst NNP cord-028721-x6f26ahr 771 11 months month NNS cord-028721-x6f26ahr 771 12 of of IN cord-028721-x6f26ahr 771 13 postnatal postnatal JJ cord-028721-x6f26ahr 771 14 life life NN cord-028721-x6f26ahr 771 15 , , , cord-028721-x6f26ahr 771 16 after after IN cord-028721-x6f26ahr 771 17 maternal maternal JJ cord-028721-x6f26ahr 771 18 human human JJ cord-028721-x6f26ahr 771 19 chorionic chorionic JJ cord-028721-x6f26ahr 771 20 gonadotropin gonadotropin NN cord-028721-x6f26ahr 771 21 is be VBZ cord-028721-x6f26ahr 771 22 gone go VBN cord-028721-x6f26ahr 771 23 . . . cord-028721-x6f26ahr 772 1 Combined combine VBN cord-028721-x6f26ahr 772 2 diffuse diffuse JJ cord-028721-x6f26ahr 772 3 and and CC cord-028721-x6f26ahr 772 4 nodular nodular JJ cord-028721-x6f26ahr 772 5 Leydig Leydig NNP cord-028721-x6f26ahr 772 6 cell cell NN cord-028721-x6f26ahr 772 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 772 8 occurs occur VBZ cord-028721-x6f26ahr 772 9 in in IN cord-028721-x6f26ahr 772 10 several several JJ cord-028721-x6f26ahr 772 11 malformative malformative JJ cord-028721-x6f26ahr 772 12 syndromes syndrome NNS cord-028721-x6f26ahr 772 13 , , , cord-028721-x6f26ahr 772 14 such such JJ cord-028721-x6f26ahr 772 15 as as IN cord-028721-x6f26ahr 772 16 Beckwith Beckwith NNP cord-028721-x6f26ahr 772 17 - - HYPH cord-028721-x6f26ahr 772 18 Wiederman Wiederman NNP cord-028721-x6f26ahr 772 19 , , , cord-028721-x6f26ahr 772 20 leprechaunism leprechaunism NN cord-028721-x6f26ahr 772 21 , , , cord-028721-x6f26ahr 772 22 triploid triploid JJ cord-028721-x6f26ahr 772 23 fetuses fetus NNS cord-028721-x6f26ahr 772 24 , , , cord-028721-x6f26ahr 772 25 fetuses fetus NNS cord-028721-x6f26ahr 772 26 with with IN cord-028721-x6f26ahr 772 27 Rh Rh NNP cord-028721-x6f26ahr 772 28 isoimmunization isoimmunization NN cord-028721-x6f26ahr 772 29 , , , cord-028721-x6f26ahr 772 30 317 317 CD cord-028721-x6f26ahr 772 31 and and CC cord-028721-x6f26ahr 772 32 in in IN cord-028721-x6f26ahr 772 33 several several JJ cord-028721-x6f26ahr 772 34 complications complication NNS cord-028721-x6f26ahr 772 35 of of IN cord-028721-x6f26ahr 772 36 pregnancy pregnancy NN cord-028721-x6f26ahr 772 37 . . . cord-028721-x6f26ahr 773 1 Compensatory compensatory JJ cord-028721-x6f26ahr 773 2 hypertrophy hypertrophy NN cord-028721-x6f26ahr 773 3 has have VBZ cord-028721-x6f26ahr 773 4 been be VBN cord-028721-x6f26ahr 773 5 observed observe VBN cord-028721-x6f26ahr 773 6 in in IN cord-028721-x6f26ahr 773 7 monorchidism monorchidism NN cord-028721-x6f26ahr 773 8 , , , cord-028721-x6f26ahr 773 9 318 318 CD cord-028721-x6f26ahr 773 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 774 1 319 319 CD cord-028721-x6f26ahr 774 2 ( ( -LRB- cord-028721-x6f26ahr 774 3 Fig fig NN cord-028721-x6f26ahr 774 4 . . . cord-028721-x6f26ahr 775 1 12 12 CD cord-028721-x6f26ahr 775 2 - - SYM cord-028721-x6f26ahr 775 3 31 31 CD cord-028721-x6f26ahr 775 4 ) ) -RRB- cord-028721-x6f26ahr 775 5 , , , cord-028721-x6f26ahr 775 6 varicocele varicocele NN cord-028721-x6f26ahr 775 7 , , , cord-028721-x6f26ahr 775 8 320 320 CD cord-028721-x6f26ahr 775 9 and and CC cord-028721-x6f26ahr 775 10 after after IN cord-028721-x6f26ahr 775 11 testicular testicular JJ cord-028721-x6f26ahr 775 12 injury injury NN cord-028721-x6f26ahr 775 13 . . . cord-028721-x6f26ahr 776 1 Hypertrophy hypertrophy NN cord-028721-x6f26ahr 776 2 persists persist VBZ cord-028721-x6f26ahr 776 3 and and CC cord-028721-x6f26ahr 776 4 may may MD cord-028721-x6f26ahr 776 5 increase increase VB cord-028721-x6f26ahr 776 6 during during IN cord-028721-x6f26ahr 776 7 childhood childhood NN cord-028721-x6f26ahr 776 8 and and CC cord-028721-x6f26ahr 776 9 puberty puberty NN cord-028721-x6f26ahr 776 10 , , , cord-028721-x6f26ahr 776 11 but but CC cord-028721-x6f26ahr 776 12 ceases cease VBZ cord-028721-x6f26ahr 776 13 thereafter thereafter RB cord-028721-x6f26ahr 776 14 ; ; : cord-028721-x6f26ahr 776 15 the the DT cord-028721-x6f26ahr 776 16 hypertrophied hypertrophied JJ cord-028721-x6f26ahr 776 17 testis testis NN cord-028721-x6f26ahr 776 18 then then RB cord-028721-x6f26ahr 776 19 becomes become VBZ cord-028721-x6f26ahr 776 20 normal normal JJ cord-028721-x6f26ahr 776 21 or or CC cord-028721-x6f26ahr 776 22 remains remain VBZ cord-028721-x6f26ahr 776 23 slightly slightly RB cord-028721-x6f26ahr 776 24 enlarged enlarged JJ cord-028721-x6f26ahr 776 25 . . . cord-028721-x6f26ahr 777 1 321 321 CD cord-028721-x6f26ahr 777 2 , , , cord-028721-x6f26ahr 777 3 322 322 CD cord-028721-x6f26ahr 777 4 The the DT cord-028721-x6f26ahr 777 5 degree degree NN cord-028721-x6f26ahr 777 6 of of IN cord-028721-x6f26ahr 777 7 hypertrophy hypertrophy NN cord-028721-x6f26ahr 777 8 is be VBZ cord-028721-x6f26ahr 777 9 determined determine VBN cord-028721-x6f26ahr 777 10 by by IN cord-028721-x6f26ahr 777 11 three three CD cord-028721-x6f26ahr 777 12 factors factor NNS cord-028721-x6f26ahr 777 13 : : : cord-028721-x6f26ahr 777 14 the the DT cord-028721-x6f26ahr 777 15 volume volume NN cord-028721-x6f26ahr 777 16 of of IN cord-028721-x6f26ahr 777 17 the the DT cord-028721-x6f26ahr 777 18 remaining remain VBG cord-028721-x6f26ahr 777 19 testicular testicular JJ cord-028721-x6f26ahr 777 20 parenchyma parenchyma NN cord-028721-x6f26ahr 777 21 , , , cord-028721-x6f26ahr 777 22 the the DT cord-028721-x6f26ahr 777 23 age age NN cord-028721-x6f26ahr 777 24 at at IN cord-028721-x6f26ahr 777 25 which which WDT cord-028721-x6f26ahr 777 26 the the DT cord-028721-x6f26ahr 777 27 injury injury NN cord-028721-x6f26ahr 777 28 occurred occur VBD cord-028721-x6f26ahr 777 29 , , , cord-028721-x6f26ahr 777 30 and and CC cord-028721-x6f26ahr 777 31 the the DT cord-028721-x6f26ahr 777 32 functional functional JJ cord-028721-x6f26ahr 777 33 ability ability NN cord-028721-x6f26ahr 777 34 of of IN cord-028721-x6f26ahr 777 35 the the DT cord-028721-x6f26ahr 777 36 descended descend VBN cord-028721-x6f26ahr 777 37 testis testis NN cord-028721-x6f26ahr 777 38 . . . cord-028721-x6f26ahr 778 1 323 323 CD cord-028721-x6f26ahr 779 1 Compensatory compensatory JJ cord-028721-x6f26ahr 779 2 hypertrophy hypertrophy NN cord-028721-x6f26ahr 779 3 results result NNS cord-028721-x6f26ahr 779 4 from from IN cord-028721-x6f26ahr 779 5 an an DT cord-028721-x6f26ahr 779 6 alteration alteration NN cord-028721-x6f26ahr 779 7 in in IN cord-028721-x6f26ahr 779 8 the the DT cord-028721-x6f26ahr 779 9 hypophyseal hypophyseal NNP cord-028721-x6f26ahr 779 10 hormonal hormonal JJ cord-028721-x6f26ahr 779 11 feedback feedback NN cord-028721-x6f26ahr 779 12 mechanism mechanism NN cord-028721-x6f26ahr 779 13 , , , cord-028721-x6f26ahr 779 14 followed follow VBN cord-028721-x6f26ahr 779 15 by by IN cord-028721-x6f26ahr 779 16 an an DT cord-028721-x6f26ahr 779 17 increase increase NN cord-028721-x6f26ahr 779 18 in in IN cord-028721-x6f26ahr 779 19 secretion secretion NN cord-028721-x6f26ahr 779 20 of of IN cord-028721-x6f26ahr 779 21 FSH fsh NN cord-028721-x6f26ahr 779 22 , , , cord-028721-x6f26ahr 779 23 evidence evidence NN cord-028721-x6f26ahr 779 24 that that IN cord-028721-x6f26ahr 779 25 the the DT cord-028721-x6f26ahr 779 26 contralateral contralateral JJ cord-028721-x6f26ahr 779 27 testis testis NN cord-028721-x6f26ahr 779 28 is be VBZ cord-028721-x6f26ahr 779 29 normal normal JJ cord-028721-x6f26ahr 779 30 . . . cord-028721-x6f26ahr 780 1 In in IN cord-028721-x6f26ahr 780 2 monorchidism monorchidism NN cord-028721-x6f26ahr 780 3 , , , cord-028721-x6f26ahr 780 4 the the DT cord-028721-x6f26ahr 780 5 testis testis NN cord-028721-x6f26ahr 780 6 is be VBZ cord-028721-x6f26ahr 780 7 initially initially RB cord-028721-x6f26ahr 780 8 normal normal JJ cord-028721-x6f26ahr 780 9 . . . cord-028721-x6f26ahr 781 1 237 237 CD cord-028721-x6f26ahr 782 1 When when WRB cord-028721-x6f26ahr 782 2 a a DT cord-028721-x6f26ahr 782 3 50 50 CD cord-028721-x6f26ahr 782 4 % % NN cord-028721-x6f26ahr 782 5 reduction reduction NN cord-028721-x6f26ahr 782 6 of of IN cord-028721-x6f26ahr 782 7 testicular testicular JJ cord-028721-x6f26ahr 782 8 mass mass NN cord-028721-x6f26ahr 782 9 occurs occur VBZ cord-028721-x6f26ahr 782 10 ( ( -LRB- cord-028721-x6f26ahr 782 11 probably probably RB cord-028721-x6f26ahr 782 12 before before IN cord-028721-x6f26ahr 782 13 birth birth NN cord-028721-x6f26ahr 782 14 ) ) -RRB- cord-028721-x6f26ahr 782 15 , , , cord-028721-x6f26ahr 782 16 the the DT cord-028721-x6f26ahr 782 17 endocrine endocrine NN cord-028721-x6f26ahr 782 18 feedback feedback NN cord-028721-x6f26ahr 782 19 changes change NNS cord-028721-x6f26ahr 782 20 and and CC cord-028721-x6f26ahr 782 21 the the DT cord-028721-x6f26ahr 782 22 resulting result VBG cord-028721-x6f26ahr 782 23 secretion secretion NN cord-028721-x6f26ahr 782 24 of of IN cord-028721-x6f26ahr 782 25 FSH fsh NN cord-028721-x6f26ahr 782 26 ( ( -LRB- cord-028721-x6f26ahr 782 27 before before RB cord-028721-x6f26ahr 782 28 or or CC cord-028721-x6f26ahr 782 29 immediately immediately RB cord-028721-x6f26ahr 782 30 after after IN cord-028721-x6f26ahr 782 31 birth birth NN cord-028721-x6f26ahr 782 32 ) ) -RRB- cord-028721-x6f26ahr 782 33 causes cause NNS cord-028721-x6f26ahr 782 34 accelerated accelerate VBN cord-028721-x6f26ahr 782 35 growth growth NN cord-028721-x6f26ahr 782 36 of of IN cord-028721-x6f26ahr 782 37 the the DT cord-028721-x6f26ahr 782 38 contralateral contralateral JJ cord-028721-x6f26ahr 782 39 testis testis NN cord-028721-x6f26ahr 782 40 . . . cord-028721-x6f26ahr 783 1 In in IN cord-028721-x6f26ahr 783 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 783 3 , , , cord-028721-x6f26ahr 783 4 the the DT cord-028721-x6f26ahr 783 5 reduction reduction NN cord-028721-x6f26ahr 783 6 in in IN cord-028721-x6f26ahr 783 7 testicular testicular JJ cord-028721-x6f26ahr 783 8 mass mass NN cord-028721-x6f26ahr 783 9 is be VBZ cord-028721-x6f26ahr 783 10 less less RBR cord-028721-x6f26ahr 783 11 severe severe JJ cord-028721-x6f26ahr 783 12 than than IN cord-028721-x6f26ahr 783 13 in in IN cord-028721-x6f26ahr 783 14 monorchidism monorchidism NN cord-028721-x6f26ahr 783 15 , , , cord-028721-x6f26ahr 783 16 and and CC cord-028721-x6f26ahr 783 17 the the DT cord-028721-x6f26ahr 783 18 scrotal scrotal JJ cord-028721-x6f26ahr 783 19 testis testis NN cord-028721-x6f26ahr 783 20 may may MD cord-028721-x6f26ahr 783 21 also also RB cord-028721-x6f26ahr 783 22 be be VB cord-028721-x6f26ahr 783 23 abnormal abnormal JJ cord-028721-x6f26ahr 783 24 , , , cord-028721-x6f26ahr 783 25 inducing induce VBG cord-028721-x6f26ahr 783 26 a a DT cord-028721-x6f26ahr 783 27 lesser less JJR cord-028721-x6f26ahr 783 28 compensatory compensatory JJ cord-028721-x6f26ahr 783 29 hypertrophy hypertrophy NN cord-028721-x6f26ahr 783 30 . . . cord-028721-x6f26ahr 784 1 Compen- Compen- NNP cord-028721-x6f26ahr 785 1 satory satory JJ cord-028721-x6f26ahr 785 2 hypertrophy hypertrophy NN cord-028721-x6f26ahr 785 3 develops develop VBZ cord-028721-x6f26ahr 785 4 between between IN cord-028721-x6f26ahr 785 5 birth birth NN cord-028721-x6f26ahr 785 6 and and CC cord-028721-x6f26ahr 785 7 3 3 CD cord-028721-x6f26ahr 785 8 years year NNS cord-028721-x6f26ahr 785 9 of of IN cord-028721-x6f26ahr 785 10 age age NN cord-028721-x6f26ahr 785 11 , , , cord-028721-x6f26ahr 785 12 and and CC cord-028721-x6f26ahr 785 13 the the DT cord-028721-x6f26ahr 785 14 testis testis NN cord-028721-x6f26ahr 785 15 may may MD cord-028721-x6f26ahr 785 16 reach reach VB cord-028721-x6f26ahr 785 17 a a DT cord-028721-x6f26ahr 785 18 volume volume NN cord-028721-x6f26ahr 785 19 twice twice RB cord-028721-x6f26ahr 785 20 normal normal JJ cord-028721-x6f26ahr 785 21 when when WRB cord-028721-x6f26ahr 785 22 the the DT cord-028721-x6f26ahr 785 23 other other JJ cord-028721-x6f26ahr 785 24 testis testis NN cord-028721-x6f26ahr 785 25 is be VBZ cord-028721-x6f26ahr 785 26 absent absent JJ cord-028721-x6f26ahr 785 27 . . . cord-028721-x6f26ahr 786 1 243 243 CD cord-028721-x6f26ahr 787 1 Some some DT cord-028721-x6f26ahr 787 2 prepubertal prepubertal JJ cord-028721-x6f26ahr 787 3 and and CC cord-028721-x6f26ahr 787 4 pubertal pubertal JJ cord-028721-x6f26ahr 787 5 patients patient NNS cord-028721-x6f26ahr 787 6 have have VBP cord-028721-x6f26ahr 787 7 pronounced pronounce VBN cord-028721-x6f26ahr 787 8 unilateral unilateral JJ cord-028721-x6f26ahr 787 9 324 324 CD cord-028721-x6f26ahr 787 10 or or CC cord-028721-x6f26ahr 787 11 bilateral bilateral JJ cord-028721-x6f26ahr 787 12 [ [ -LRB- cord-028721-x6f26ahr 787 13 325 325 CD cord-028721-x6f26ahr 787 14 ] ] -RRB- cord-028721-x6f26ahr 787 15 [ [ -LRB- cord-028721-x6f26ahr 787 16 326 326 CD cord-028721-x6f26ahr 787 17 ] ] -RRB- cord-028721-x6f26ahr 787 18 [ [ -LRB- cord-028721-x6f26ahr 787 19 327 327 CD cord-028721-x6f26ahr 787 20 ] ] -RRB- cord-028721-x6f26ahr 787 21 testicular testicular JJ cord-028721-x6f26ahr 787 22 hypertrophy hypertrophy NN cord-028721-x6f26ahr 787 23 in in IN cord-028721-x6f26ahr 787 24 the the DT cord-028721-x6f26ahr 787 25 absence absence NN cord-028721-x6f26ahr 787 26 of of IN cord-028721-x6f26ahr 787 27 other other JJ cord-028721-x6f26ahr 787 28 pathologic pathologic JJ cord-028721-x6f26ahr 787 29 fi fi NN cord-028721-x6f26ahr 787 30 ndings nding NNS cord-028721-x6f26ahr 787 31 . . . cord-028721-x6f26ahr 788 1 This this DT cord-028721-x6f26ahr 788 2 probably probably RB cord-028721-x6f26ahr 788 3 results result VBZ cord-028721-x6f26ahr 788 4 from from IN cord-028721-x6f26ahr 788 5 hormonal hormonal JJ cord-028721-x6f26ahr 788 6 receptivity receptivity NN cord-028721-x6f26ahr 788 7 in in IN cord-028721-x6f26ahr 788 8 the the DT cord-028721-x6f26ahr 788 9 testicular testicular JJ cord-028721-x6f26ahr 788 10 parenchyma parenchyma NN cord-028721-x6f26ahr 788 11 . . . cord-028721-x6f26ahr 789 1 Morphometric morphometric JJ cord-028721-x6f26ahr 789 2 studies study NNS cord-028721-x6f26ahr 789 3 have have VBP cord-028721-x6f26ahr 789 4 shown show VBN cord-028721-x6f26ahr 789 5 that that IN cord-028721-x6f26ahr 789 6 the the DT cord-028721-x6f26ahr 789 7 testicular testicular JJ cord-028721-x6f26ahr 789 8 enlargement enlargement NN cord-028721-x6f26ahr 789 9 is be VBZ cord-028721-x6f26ahr 789 10 chiefl chiefl NNP cord-028721-x6f26ahr 789 11 y y NNP cord-028721-x6f26ahr 789 12 due due JJ cord-028721-x6f26ahr 789 13 to to IN cord-028721-x6f26ahr 789 14 an an DT cord-028721-x6f26ahr 789 15 increase increase NN cord-028721-x6f26ahr 789 16 in in IN cord-028721-x6f26ahr 789 17 the the DT cord-028721-x6f26ahr 789 18 length length NN cord-028721-x6f26ahr 789 19 of of IN cord-028721-x6f26ahr 789 20 the the DT cord-028721-x6f26ahr 789 21 seminiferous seminiferous JJ cord-028721-x6f26ahr 789 22 tubules tubule NNS cord-028721-x6f26ahr 789 23 , , , cord-028721-x6f26ahr 789 24 although although IN cord-028721-x6f26ahr 789 25 increases increase NNS cord-028721-x6f26ahr 789 26 in in IN cord-028721-x6f26ahr 789 27 tubular tubular JJ cord-028721-x6f26ahr 789 28 diameter diameter NN cord-028721-x6f26ahr 789 29 and and CC cord-028721-x6f26ahr 789 30 Sertoli sertoli JJ cord-028721-x6f26ahr 789 31 cell cell NN cord-028721-x6f26ahr 789 32 numbers number NNS cord-028721-x6f26ahr 789 33 have have VBP cord-028721-x6f26ahr 789 34 also also RB cord-028721-x6f26ahr 789 35 been be VBN cord-028721-x6f26ahr 789 36 observed observe VBN cord-028721-x6f26ahr 789 37 . . . cord-028721-x6f26ahr 790 1 Elevated elevated JJ cord-028721-x6f26ahr 790 2 FSH fsh NN cord-028721-x6f26ahr 790 3 serum serum NN cord-028721-x6f26ahr 790 4 levels level NNS cord-028721-x6f26ahr 790 5 , , , cord-028721-x6f26ahr 790 6 reported report VBN cord-028721-x6f26ahr 790 7 in in IN cord-028721-x6f26ahr 790 8 some some DT cord-028721-x6f26ahr 790 9 cases case NNS cord-028721-x6f26ahr 790 10 , , , cord-028721-x6f26ahr 790 11 or or CC cord-028721-x6f26ahr 790 12 hyperactive hyperactive JJ cord-028721-x6f26ahr 790 13 FSH fsh NN cord-028721-x6f26ahr 790 14 receptors receptor NNS cord-028721-x6f26ahr 790 15 might may MD cord-028721-x6f26ahr 790 16 be be VB cord-028721-x6f26ahr 790 17 the the DT cord-028721-x6f26ahr 790 18 cause cause NN cord-028721-x6f26ahr 790 19 of of IN cord-028721-x6f26ahr 790 20 the the DT cord-028721-x6f26ahr 790 21 excessive excessive JJ cord-028721-x6f26ahr 790 22 Sertoli sertoli JJ cord-028721-x6f26ahr 790 23 cell cell NN cord-028721-x6f26ahr 790 24 proliferation proliferation NN cord-028721-x6f26ahr 790 25 and and CC cord-028721-x6f26ahr 790 26 the the DT cord-028721-x6f26ahr 790 27 lengthening lengthening NN cord-028721-x6f26ahr 790 28 and and CC cord-028721-x6f26ahr 790 29 thickening thickening NN cord-028721-x6f26ahr 790 30 of of IN cord-028721-x6f26ahr 790 31 seminiferous seminiferous JJ cord-028721-x6f26ahr 790 32 tubules tubule NNS cord-028721-x6f26ahr 790 33 . . . cord-028721-x6f26ahr 791 1 [ [ -LRB- cord-028721-x6f26ahr 791 2 328 328 CD cord-028721-x6f26ahr 791 3 ] ] -RRB- cord-028721-x6f26ahr 791 4 [ [ -LRB- cord-028721-x6f26ahr 791 5 329 329 CD cord-028721-x6f26ahr 791 6 ] ] -RRB- cord-028721-x6f26ahr 791 7 [ [ -LRB- cord-028721-x6f26ahr 791 8 330 330 CD cord-028721-x6f26ahr 791 9 ] ] -RRB- cord-028721-x6f26ahr 792 1 In in IN cord-028721-x6f26ahr 792 2 addition addition NN cord-028721-x6f26ahr 792 3 , , , cord-028721-x6f26ahr 792 4 Leydig leydig NN cord-028721-x6f26ahr 792 5 cell cell NN cord-028721-x6f26ahr 792 6 hyperplasia hyperplasia NN cord-028721-x6f26ahr 792 7 and and CC cord-028721-x6f26ahr 792 8 defi defi NNP cord-028721-x6f26ahr 792 9 cient cient NNP cord-028721-x6f26ahr 792 10 spermatogenesis spermatogenesis NNP cord-028721-x6f26ahr 792 11 are be VBP cord-028721-x6f26ahr 792 12 frequent frequent JJ cord-028721-x6f26ahr 792 13 fi fi NN cord-028721-x6f26ahr 792 14 ndings nding NNS cord-028721-x6f26ahr 792 15 in in IN cord-028721-x6f26ahr 792 16 adult adult NN cord-028721-x6f26ahr 792 17 life life NN cord-028721-x6f26ahr 792 18 . . . cord-028721-x6f26ahr 793 1 As as IN cord-028721-x6f26ahr 793 2 the the DT cord-028721-x6f26ahr 793 3 development development NN cord-028721-x6f26ahr 793 4 of of IN cord-028721-x6f26ahr 793 5 the the DT cord-028721-x6f26ahr 793 6 two two CD cord-028721-x6f26ahr 793 7 testes testis NNS cord-028721-x6f26ahr 793 8 may may MD cord-028721-x6f26ahr 793 9 be be VB cord-028721-x6f26ahr 793 10 asynchronous asynchronous JJ cord-028721-x6f26ahr 793 11 during during IN cord-028721-x6f26ahr 793 12 puberty puberty NN cord-028721-x6f26ahr 793 13 , , , cord-028721-x6f26ahr 793 14 some some DT cord-028721-x6f26ahr 793 15 unilateral unilateral JJ cord-028721-x6f26ahr 793 16 macroorchidisms macroorchidism NNS cord-028721-x6f26ahr 793 17 may may MD cord-028721-x6f26ahr 793 18 represent represent VB cord-028721-x6f26ahr 793 19 cases case NNS cord-028721-x6f26ahr 793 20 in in IN cord-028721-x6f26ahr 793 21 which which WDT cord-028721-x6f26ahr 793 22 these these DT cord-028721-x6f26ahr 793 23 differences difference NNS cord-028721-x6f26ahr 793 24 are be VBP cord-028721-x6f26ahr 793 25 unusually unusually RB cord-028721-x6f26ahr 793 26 exaggerated exaggerated JJ cord-028721-x6f26ahr 793 27 . . . cord-028721-x6f26ahr 794 1 About about RB cord-028721-x6f26ahr 794 2 2 2 CD cord-028721-x6f26ahr 794 3 % % NN cord-028721-x6f26ahr 794 4 of of IN cord-028721-x6f26ahr 794 5 adults adult NNS cord-028721-x6f26ahr 794 6 with with IN cord-028721-x6f26ahr 794 7 fertility fertility NN cord-028721-x6f26ahr 794 8 problems problem NNS cord-028721-x6f26ahr 794 9 have have VBP cord-028721-x6f26ahr 794 10 enlarged enlarge VBN cord-028721-x6f26ahr 794 11 testes testis NNS cord-028721-x6f26ahr 794 12 , , , cord-028721-x6f26ahr 794 13 with with IN cord-028721-x6f26ahr 794 14 volumes volume NNS cord-028721-x6f26ahr 794 15 over over IN cord-028721-x6f26ahr 794 16 25 25 CD cord-028721-x6f26ahr 794 17 mL ml NN cord-028721-x6f26ahr 794 18 , , , cord-028721-x6f26ahr 794 19 and and CC cord-028721-x6f26ahr 794 20 low low JJ cord-028721-x6f26ahr 794 21 levels level NNS cord-028721-x6f26ahr 794 22 of of IN cord-028721-x6f26ahr 794 23 FSH fsh NN cord-028721-x6f26ahr 794 24 , , , cord-028721-x6f26ahr 794 25 LH lh NN cord-028721-x6f26ahr 794 26 , , , cord-028721-x6f26ahr 794 27 testosterone testosterone NN cord-028721-x6f26ahr 794 28 , , , cord-028721-x6f26ahr 794 29 prolactin prolactin NN cord-028721-x6f26ahr 794 30 , , , cord-028721-x6f26ahr 794 31 and and CC cord-028721-x6f26ahr 794 32 estradiol estradiol NN cord-028721-x6f26ahr 794 33 . . . cord-028721-x6f26ahr 795 1 331 331 CD cord-028721-x6f26ahr 796 1 Despite despite IN cord-028721-x6f26ahr 796 2 the the DT cord-028721-x6f26ahr 796 3 important important JJ cord-028721-x6f26ahr 796 4 hormonal hormonal JJ cord-028721-x6f26ahr 796 5 changes change NNS cord-028721-x6f26ahr 796 6 , , , cord-028721-x6f26ahr 796 7 sperm sperm NN cord-028721-x6f26ahr 796 8 concentrations concentration NNS cord-028721-x6f26ahr 796 9 and and CC cord-028721-x6f26ahr 796 10 total total JJ cord-028721-x6f26ahr 796 11 numbers number NNS cord-028721-x6f26ahr 796 12 of of IN cord-028721-x6f26ahr 796 13 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 796 14 are be VBP cord-028721-x6f26ahr 796 15 higher high JJR cord-028721-x6f26ahr 796 16 than than IN cord-028721-x6f26ahr 796 17 normal normal JJ cord-028721-x6f26ahr 796 18 . . . cord-028721-x6f26ahr 797 1 Low low JJ cord-028721-x6f26ahr 797 2 FSH fsh NN cord-028721-x6f26ahr 797 3 levels level NNS cord-028721-x6f26ahr 797 4 may may MD cord-028721-x6f26ahr 797 5 be be VB cord-028721-x6f26ahr 797 6 attributable attributable JJ cord-028721-x6f26ahr 797 7 to to IN cord-028721-x6f26ahr 797 8 increased increase VBN cord-028721-x6f26ahr 797 9 inhibin inhibin NN cord-028721-x6f26ahr 797 10 secretion secretion NN cord-028721-x6f26ahr 797 11 because because IN cord-028721-x6f26ahr 797 12 the the DT cord-028721-x6f26ahr 797 13 number number NN cord-028721-x6f26ahr 797 14 of of IN cord-028721-x6f26ahr 797 15 Sertoli sertoli JJ cord-028721-x6f26ahr 797 16 cells cell NNS cord-028721-x6f26ahr 797 17 is be VBZ cord-028721-x6f26ahr 797 18 elevated elevate VBN cord-028721-x6f26ahr 797 19 in in IN cord-028721-x6f26ahr 797 20 these these DT cord-028721-x6f26ahr 797 21 testes testis NNS cord-028721-x6f26ahr 797 22 , , , cord-028721-x6f26ahr 797 23 but but CC cord-028721-x6f26ahr 797 24 no no DT cord-028721-x6f26ahr 797 25 explanation explanation NN cord-028721-x6f26ahr 797 26 for for IN cord-028721-x6f26ahr 797 27 the the DT cord-028721-x6f26ahr 797 28 reduction reduction NN cord-028721-x6f26ahr 797 29 in in IN cord-028721-x6f26ahr 797 30 the the DT cord-028721-x6f26ahr 797 31 other other JJ cord-028721-x6f26ahr 797 32 hormone hormone NN cord-028721-x6f26ahr 797 33 levels level NNS cord-028721-x6f26ahr 797 34 has have VBZ cord-028721-x6f26ahr 797 35 been be VBN cord-028721-x6f26ahr 797 36 found find VBN cord-028721-x6f26ahr 797 37 . . . cord-028721-x6f26ahr 798 1 Fragile fragile JJ cord-028721-x6f26ahr 798 2 X x NN cord-028721-x6f26ahr 798 3 chromosome chromosome NN cord-028721-x6f26ahr 798 4 is be VBZ cord-028721-x6f26ahr 798 5 the the DT cord-028721-x6f26ahr 798 6 best well RBS cord-028721-x6f26ahr 798 7 - - HYPH cord-028721-x6f26ahr 798 8 known know VBN cord-028721-x6f26ahr 798 9 form form NN cord-028721-x6f26ahr 798 10 of of IN cord-028721-x6f26ahr 798 11 inherited inherit VBN cord-028721-x6f26ahr 798 12 mental mental JJ cord-028721-x6f26ahr 798 13 retardation retardation NN cord-028721-x6f26ahr 798 14 , , , cord-028721-x6f26ahr 798 15 with with IN cord-028721-x6f26ahr 798 16 an an DT cord-028721-x6f26ahr 798 17 incidence incidence NN cord-028721-x6f26ahr 798 18 of of IN cord-028721-x6f26ahr 798 19 1 1 CD cord-028721-x6f26ahr 798 20 in in IN cord-028721-x6f26ahr 798 21 1500 1500 CD cord-028721-x6f26ahr 798 22 males male NNS cord-028721-x6f26ahr 798 23 and and CC cord-028721-x6f26ahr 798 24 1 1 CD cord-028721-x6f26ahr 798 25 in in IN cord-028721-x6f26ahr 798 26 2500 2500 CD cord-028721-x6f26ahr 798 27 females female NNS cord-028721-x6f26ahr 798 28 . . . cord-028721-x6f26ahr 799 1 332 332 CD cord-028721-x6f26ahr 800 1 In in IN cord-028721-x6f26ahr 800 2 addition addition NN cord-028721-x6f26ahr 800 3 to to IN cord-028721-x6f26ahr 800 4 facial facial JJ cord-028721-x6f26ahr 800 5 dysmorphia dysmorphia NN cord-028721-x6f26ahr 800 6 ( ( -LRB- cord-028721-x6f26ahr 800 7 large large JJ cord-028721-x6f26ahr 800 8 ears ear NNS cord-028721-x6f26ahr 800 9 , , , cord-028721-x6f26ahr 800 10 prognathism prognathism NN cord-028721-x6f26ahr 800 11 , , , cord-028721-x6f26ahr 800 12 high high JJ cord-028721-x6f26ahr 800 13 forehead forehead NN cord-028721-x6f26ahr 800 14 , , , cord-028721-x6f26ahr 800 15 and and CC cord-028721-x6f26ahr 800 16 arched arched JJ cord-028721-x6f26ahr 800 17 palate palate NN cord-028721-x6f26ahr 800 18 ) ) -RRB- cord-028721-x6f26ahr 800 19 , , , cord-028721-x6f26ahr 800 20 macroorchidism macroorchidism NNP cord-028721-x6f26ahr 800 21 ( ( -LRB- cord-028721-x6f26ahr 800 22 Martin Martin NNP cord-028721-x6f26ahr 800 23 - - HYPH cord-028721-x6f26ahr 800 24 Bell Bell NNP cord-028721-x6f26ahr 800 25 syndrome syndrome NN cord-028721-x6f26ahr 800 26 ) ) -RRB- cord-028721-x6f26ahr 800 27 is be VBZ cord-028721-x6f26ahr 800 28 often often RB cord-028721-x6f26ahr 800 29 an an DT cord-028721-x6f26ahr 800 30 associated associated JJ cord-028721-x6f26ahr 800 31 fi fi NN cord-028721-x6f26ahr 800 32 nding nding NN cord-028721-x6f26ahr 800 33 . . . cord-028721-x6f26ahr 801 1 [ [ -LRB- cord-028721-x6f26ahr 801 2 333 333 CD cord-028721-x6f26ahr 801 3 ] ] -RRB- cord-028721-x6f26ahr 801 4 [ [ -LRB- cord-028721-x6f26ahr 801 5 334 334 CD cord-028721-x6f26ahr 801 6 ] ] -RRB- cord-028721-x6f26ahr 801 7 [ [ -LRB- cord-028721-x6f26ahr 801 8 335 335 CD cord-028721-x6f26ahr 801 9 ] ] -RRB- cord-028721-x6f26ahr 801 10 [ [ -LRB- cord-028721-x6f26ahr 801 11 336 336 CD cord-028721-x6f26ahr 801 12 ] ] -RRB- cord-028721-x6f26ahr 801 13 [ [ -LRB- cord-028721-x6f26ahr 801 14 337 337 CD cord-028721-x6f26ahr 801 15 ] ] -RRB- cord-028721-x6f26ahr 802 1 The the DT cord-028721-x6f26ahr 802 2 impaired impaired JJ cord-028721-x6f26ahr 802 3 gene gene NN cord-028721-x6f26ahr 802 4 ( ( -LRB- cord-028721-x6f26ahr 802 5 FMR1 FMR1 NNP cord-028721-x6f26ahr 802 6 gene gene NN cord-028721-x6f26ahr 802 7 ) ) -RRB- cord-028721-x6f26ahr 802 8 is be VBZ cord-028721-x6f26ahr 802 9 mapped map VBN cord-028721-x6f26ahr 802 10 to to IN cord-028721-x6f26ahr 802 11 Xq27,3 Xq27,3 NNP cord-028721-x6f26ahr 802 12 which which WDT cord-028721-x6f26ahr 802 13 is be VBZ cord-028721-x6f26ahr 802 14 genetically genetically RB cord-028721-x6f26ahr 802 15 fragile fragile JJ cord-028721-x6f26ahr 802 16 . . . cord-028721-x6f26ahr 803 1 The the DT cord-028721-x6f26ahr 803 2 gene gene NN cord-028721-x6f26ahr 803 3 alteration alteration NN cord-028721-x6f26ahr 803 4 is be VBZ cord-028721-x6f26ahr 803 5 due due JJ cord-028721-x6f26ahr 803 6 to to IN cord-028721-x6f26ahr 803 7 a a DT cord-028721-x6f26ahr 803 8 lengthening lengthening NN cord-028721-x6f26ahr 803 9 of of IN cord-028721-x6f26ahr 803 10 a a DT cord-028721-x6f26ahr 803 11 trinucleotide trinucleotide JJ cord-028721-x6f26ahr 803 12 CGG CGG NNP cord-028721-x6f26ahr 803 13 repeat repeat NN cord-028721-x6f26ahr 803 14 that that WDT cord-028721-x6f26ahr 803 15 results result VBZ cord-028721-x6f26ahr 803 16 in in IN cord-028721-x6f26ahr 803 17 FMR1 FMR1 NNP cord-028721-x6f26ahr 803 18 gene gene NN cord-028721-x6f26ahr 803 19 silencing silencing NN cord-028721-x6f26ahr 803 20 . . . cord-028721-x6f26ahr 804 1 If if IN cord-028721-x6f26ahr 804 2 the the DT cord-028721-x6f26ahr 804 3 CGG CGG NNP cord-028721-x6f26ahr 804 4 sequence sequence NN cord-028721-x6f26ahr 804 5 is be VBZ cord-028721-x6f26ahr 804 6 repeated repeat VBN cord-028721-x6f26ahr 804 7 fewer few JJR cord-028721-x6f26ahr 804 8 than than IN cord-028721-x6f26ahr 804 9 200 200 CD cord-028721-x6f26ahr 804 10 times time NNS cord-028721-x6f26ahr 804 11 , , , cord-028721-x6f26ahr 804 12 the the DT cord-028721-x6f26ahr 804 13 disorder disorder NN cord-028721-x6f26ahr 804 14 is be VBZ cord-028721-x6f26ahr 804 15 considered consider VBN cord-028721-x6f26ahr 804 16 a a DT cord-028721-x6f26ahr 804 17 premutation premutation NN cord-028721-x6f26ahr 804 18 and and CC cord-028721-x6f26ahr 804 19 males male NNS cord-028721-x6f26ahr 804 20 show show VBP cord-028721-x6f26ahr 804 21 no no DT cord-028721-x6f26ahr 804 22 symptoms symptom NNS cord-028721-x6f26ahr 804 23 ; ; : cord-028721-x6f26ahr 804 24 if if IN cord-028721-x6f26ahr 804 25 the the DT cord-028721-x6f26ahr 804 26 number number NN cord-028721-x6f26ahr 804 27 of of IN cord-028721-x6f26ahr 804 28 repetitions repetition NNS cord-028721-x6f26ahr 804 29 exceeds exceed VBZ cord-028721-x6f26ahr 804 30 200 200 CD cord-028721-x6f26ahr 804 31 , , , cord-028721-x6f26ahr 804 32 mutation mutation NN cord-028721-x6f26ahr 804 33 is be VBZ cord-028721-x6f26ahr 804 34 complete complete JJ cord-028721-x6f26ahr 804 35 and and CC cord-028721-x6f26ahr 804 36 all all DT cord-028721-x6f26ahr 804 37 show show VBP cord-028721-x6f26ahr 804 38 the the DT cord-028721-x6f26ahr 804 39 disorder disorder NN cord-028721-x6f26ahr 804 40 . . . cord-028721-x6f26ahr 805 1 [ [ -LRB- cord-028721-x6f26ahr 805 2 338 338 CD cord-028721-x6f26ahr 805 3 ] ] -RRB- cord-028721-x6f26ahr 805 4 [ [ -LRB- cord-028721-x6f26ahr 805 5 339 339 CD cord-028721-x6f26ahr 805 6 ] ] -RRB- cord-028721-x6f26ahr 805 7 [ [ -LRB- cord-028721-x6f26ahr 805 8 340 340 CD cord-028721-x6f26ahr 805 9 ] ] -RRB- cord-028721-x6f26ahr 806 1 In in IN cord-028721-x6f26ahr 806 2 men man NNS cord-028721-x6f26ahr 806 3 with with IN cord-028721-x6f26ahr 806 4 this this DT cord-028721-x6f26ahr 806 5 syndrome syndrome NN cord-028721-x6f26ahr 806 6 , , , cord-028721-x6f26ahr 806 7 the the DT cord-028721-x6f26ahr 806 8 average average JJ cord-028721-x6f26ahr 806 9 testicular testicular JJ cord-028721-x6f26ahr 806 10 volume volume NN cord-028721-x6f26ahr 806 11 is be VBZ cord-028721-x6f26ahr 807 1 more more JJR cord-028721-x6f26ahr 807 2 than than IN cord-028721-x6f26ahr 807 3 70 70 CD cord-028721-x6f26ahr 807 4 mL ml NN cord-028721-x6f26ahr 807 5 ( ( -LRB- cord-028721-x6f26ahr 807 6 four four CD cord-028721-x6f26ahr 807 7 times time NNS cord-028721-x6f26ahr 807 8 greater great JJR cord-028721-x6f26ahr 807 9 than than IN cord-028721-x6f26ahr 807 10 normal normal JJ cord-028721-x6f26ahr 807 11 ) ) -RRB- cord-028721-x6f26ahr 807 12 . . . cord-028721-x6f26ahr 808 1 The the DT cord-028721-x6f26ahr 808 2 penis penis NN cord-028721-x6f26ahr 808 3 also also RB cord-028721-x6f26ahr 808 4 is be VBZ cord-028721-x6f26ahr 808 5 larger large JJR cord-028721-x6f26ahr 808 6 than than IN cord-028721-x6f26ahr 808 7 normal normal JJ cord-028721-x6f26ahr 808 8 , , , cord-028721-x6f26ahr 808 9 and and CC cord-028721-x6f26ahr 808 10 both both DT cord-028721-x6f26ahr 808 11 anomalies anomaly NNS cord-028721-x6f26ahr 808 12 are be VBP cord-028721-x6f26ahr 808 13 apparent apparent JJ cord-028721-x6f26ahr 808 14 in in IN cord-028721-x6f26ahr 808 15 infancy infancy NN cord-028721-x6f26ahr 808 16 . . . cord-028721-x6f26ahr 809 1 The the DT cord-028721-x6f26ahr 809 2 scrotum scrotum NN cord-028721-x6f26ahr 809 3 is be VBZ cord-028721-x6f26ahr 809 4 also also RB cord-028721-x6f26ahr 809 5 enlarged enlarge VBN cord-028721-x6f26ahr 809 6 and and CC cord-028721-x6f26ahr 809 7 prematurely prematurely RB cord-028721-x6f26ahr 809 8 pigmented pigmented JJ cord-028721-x6f26ahr 809 9 . . . cord-028721-x6f26ahr 810 1 This this DT cord-028721-x6f26ahr 810 2 precocious precocious JJ cord-028721-x6f26ahr 810 3 genital genital JJ cord-028721-x6f26ahr 810 4 development development NN cord-028721-x6f26ahr 810 5 is be VBZ cord-028721-x6f26ahr 810 6 diffi diffi JJ cord-028721-x6f26ahr 810 7 cult cult NN cord-028721-x6f26ahr 810 8 to to TO cord-028721-x6f26ahr 810 9 explain explain VB cord-028721-x6f26ahr 810 10 because because IN cord-028721-x6f26ahr 810 11 the the DT cord-028721-x6f26ahr 810 12 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 810 13 axis axis NN cord-028721-x6f26ahr 810 14 is be VBZ cord-028721-x6f26ahr 810 15 normal normal JJ cord-028721-x6f26ahr 810 16 , , , cord-028721-x6f26ahr 810 17 but but CC cord-028721-x6f26ahr 810 18 it -PRON- PRP cord-028721-x6f26ahr 810 19 may may MD cord-028721-x6f26ahr 810 20 be be VB cord-028721-x6f26ahr 810 21 caused cause VBN cord-028721-x6f26ahr 810 22 by by IN cord-028721-x6f26ahr 810 23 increased increase VBN cord-028721-x6f26ahr 810 24 sensitivity sensitivity NN cord-028721-x6f26ahr 810 25 to to IN cord-028721-x6f26ahr 810 26 stimulation stimulation NN cord-028721-x6f26ahr 810 27 by by IN cord-028721-x6f26ahr 810 28 FSH fsh NN cord-028721-x6f26ahr 810 29 . . . cord-028721-x6f26ahr 811 1 341 341 CD cord-028721-x6f26ahr 811 2 Testicular Testicular NNP cord-028721-x6f26ahr 811 3 biopsies biopsy NNS cord-028721-x6f26ahr 811 4 from from IN cord-028721-x6f26ahr 811 5 adults adult NNS cord-028721-x6f26ahr 811 6 may may MD cord-028721-x6f26ahr 811 7 be be VB cord-028721-x6f26ahr 811 8 normal normal JJ cord-028721-x6f26ahr 811 9 or or CC cord-028721-x6f26ahr 811 10 show show VB cord-028721-x6f26ahr 811 11 interstitial interstitial JJ cord-028721-x6f26ahr 811 12 edema edema NN cord-028721-x6f26ahr 811 13 and and CC cord-028721-x6f26ahr 811 14 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 812 1 ( ( -LRB- cord-028721-x6f26ahr 812 2 Fig Fig NNP cord-028721-x6f26ahr 812 3 . . . cord-028721-x6f26ahr 812 4 12 12 CD cord-028721-x6f26ahr 812 5 - - SYM cord-028721-x6f26ahr 812 6 32 32 CD cord-028721-x6f26ahr 812 7 ) ) -RRB- cord-028721-x6f26ahr 812 8 . . . cord-028721-x6f26ahr 813 1 Usually usually RB cord-028721-x6f26ahr 813 2 , , , cord-028721-x6f26ahr 813 3 there there EX cord-028721-x6f26ahr 813 4 is be VBZ cord-028721-x6f26ahr 813 5 normal normal JJ cord-028721-x6f26ahr 813 6 testicular testicular JJ cord-028721-x6f26ahr 813 7 parenchyma parenchyma NN cord-028721-x6f26ahr 813 8 with with IN cord-028721-x6f26ahr 813 9 focal focal JJ cord-028721-x6f26ahr 813 10 reduced reduced JJ cord-028721-x6f26ahr 813 11 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 813 12 and and CC cord-028721-x6f26ahr 813 13 Sertoli sertoli JJ cord-028721-x6f26ahr 813 14 cell cell NN cord-028721-x6f26ahr 813 15 hyperplasia hyperplasia NN cord-028721-x6f26ahr 814 1 ( ( -LRB- cord-028721-x6f26ahr 814 2 Fig Fig NNP cord-028721-x6f26ahr 814 3 . . . cord-028721-x6f26ahr 814 4 _SP cord-028721-x6f26ahr 814 5 12 12 CD cord-028721-x6f26ahr 814 6 -33 -33 NNS cord-028721-x6f26ahr 814 7 ) ) -RRB- cord-028721-x6f26ahr 814 8 or or CC cord-028721-x6f26ahr 814 9 tubules tubule NNS cord-028721-x6f26ahr 814 10 containing contain VBG cord-028721-x6f26ahr 814 11 only only RB cord-028721-x6f26ahr 814 12 immature immature JJ cord-028721-x6f26ahr 814 13 Sertoli Sertoli NNP cord-028721-x6f26ahr 814 14 cells cell NNS cord-028721-x6f26ahr 814 15 . . . cord-028721-x6f26ahr 815 1 Morphometry Morphometry NNP cord-028721-x6f26ahr 815 2 indicates indicate VBZ cord-028721-x6f26ahr 815 3 that that IN cord-028721-x6f26ahr 815 4 testicular testicular JJ cord-028721-x6f26ahr 815 5 enlargement enlargement NN cord-028721-x6f26ahr 815 6 is be VBZ cord-028721-x6f26ahr 815 7 chiefl chiefl NNP cord-028721-x6f26ahr 815 8 y y NNP cord-028721-x6f26ahr 815 9 the the DT cord-028721-x6f26ahr 815 10 result result NN cord-028721-x6f26ahr 815 11 of of IN cord-028721-x6f26ahr 815 12 lengthening lengthening NN cord-028721-x6f26ahr 815 13 of of IN cord-028721-x6f26ahr 815 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 815 15 tubules tubule NNS cord-028721-x6f26ahr 815 16 . . . cord-028721-x6f26ahr 816 1 328 328 CD cord-028721-x6f26ahr 817 1 The the DT cord-028721-x6f26ahr 817 2 low low JJ cord-028721-x6f26ahr 817 3 number number NN cord-028721-x6f26ahr 817 4 of of IN cord-028721-x6f26ahr 817 5 spermatids spermatid NNS cord-028721-x6f26ahr 817 6 is be VBZ cord-028721-x6f26ahr 817 7 attributed attribute VBN cord-028721-x6f26ahr 817 8 to to IN cord-028721-x6f26ahr 817 9 atrophy atrophy NN cord-028721-x6f26ahr 817 10 caused cause VBN cord-028721-x6f26ahr 817 11 by by IN cord-028721-x6f26ahr 817 12 compression compression NN cord-028721-x6f26ahr 817 13 of of IN cord-028721-x6f26ahr 817 14 the the DT cord-028721-x6f26ahr 817 15 seminiferous seminiferous JJ cord-028721-x6f26ahr 817 16 epithelium epithelium NN cord-028721-x6f26ahr 817 17 by by IN cord-028721-x6f26ahr 817 18 marked marked JJ cord-028721-x6f26ahr 817 19 increase increase NN cord-028721-x6f26ahr 817 20 in in IN cord-028721-x6f26ahr 817 21 intratubular intratubular NNP cord-028721-x6f26ahr 817 22 fl fl NNP cord-028721-x6f26ahr 817 23 uid uid NN cord-028721-x6f26ahr 817 24 . . . cord-028721-x6f26ahr 818 1 342 342 CD cord-028721-x6f26ahr 818 2 Meiotic meiotic JJ cord-028721-x6f26ahr 818 3 anomalies anomaly NNS cord-028721-x6f26ahr 818 4 have have VBP cord-028721-x6f26ahr 818 5 been be VBN cord-028721-x6f26ahr 818 6 excluded exclude VBN cord-028721-x6f26ahr 818 7 . . . cord-028721-x6f26ahr 819 1 343 343 CD cord-028721-x6f26ahr 820 1 The the DT cord-028721-x6f26ahr 820 2 fragile fragile JJ cord-028721-x6f26ahr 820 3 X x NN cord-028721-x6f26ahr 820 4 syndrome syndrome NN cord-028721-x6f26ahr 820 5 is be VBZ cord-028721-x6f26ahr 820 6 second second JJ cord-028721-x6f26ahr 820 7 in in IN cord-028721-x6f26ahr 820 8 frequency frequency NN cord-028721-x6f26ahr 820 9 only only RB cord-028721-x6f26ahr 820 10 to to IN cord-028721-x6f26ahr 820 11 Down Down NNP cord-028721-x6f26ahr 820 12 's 's POS cord-028721-x6f26ahr 820 13 syndrome syndrome NN cord-028721-x6f26ahr 820 14 as as IN cord-028721-x6f26ahr 820 15 a a DT cord-028721-x6f26ahr 820 16 cause cause NN cord-028721-x6f26ahr 820 17 of of IN cord-028721-x6f26ahr 820 18 mental mental JJ cord-028721-x6f26ahr 820 19 retardation retardation NN cord-028721-x6f26ahr 820 20 . . . cord-028721-x6f26ahr 821 1 [ [ -LRB- cord-028721-x6f26ahr 821 2 344 344 CD cord-028721-x6f26ahr 821 3 ] ] -RRB- cord-028721-x6f26ahr 821 4 [ [ -LRB- cord-028721-x6f26ahr 821 5 345 345 CD cord-028721-x6f26ahr 821 6 ] ] -RRB- cord-028721-x6f26ahr 821 7 [ [ -LRB- cord-028721-x6f26ahr 821 8 346 346 CD cord-028721-x6f26ahr 821 9 ] ] -RRB- cord-028721-x6f26ahr 822 1 However however RB cord-028721-x6f26ahr 822 2 , , , cord-028721-x6f26ahr 822 3 this this DT cord-028721-x6f26ahr 822 4 chromosomal chromosomal JJ cord-028721-x6f26ahr 822 5 anomaly anomaly NN cord-028721-x6f26ahr 822 6 is be VBZ cord-028721-x6f26ahr 822 7 not not RB cord-028721-x6f26ahr 822 8 always always RB cord-028721-x6f26ahr 822 9 associated associate VBN cord-028721-x6f26ahr 822 10 with with IN cord-028721-x6f26ahr 822 11 mental mental JJ cord-028721-x6f26ahr 822 12 retardation retardation NN cord-028721-x6f26ahr 822 13 or or CC cord-028721-x6f26ahr 822 14 macroorchidism macroorchidism NN cord-028721-x6f26ahr 822 15 , , , cord-028721-x6f26ahr 822 16 and and CC cord-028721-x6f26ahr 822 17 there there EX cord-028721-x6f26ahr 822 18 are be VBP cord-028721-x6f26ahr 822 19 men man NNS cord-028721-x6f26ahr 822 20 with with IN cord-028721-x6f26ahr 822 21 fragile fragile JJ cord-028721-x6f26ahr 822 22 X x NN cord-028721-x6f26ahr 822 23 syndrome syndrome NN cord-028721-x6f26ahr 822 24 who who WP cord-028721-x6f26ahr 822 25 are be VBP cord-028721-x6f26ahr 822 26 otherwise otherwise RB cord-028721-x6f26ahr 822 27 normal normal JJ cord-028721-x6f26ahr 822 28 . . . cord-028721-x6f26ahr 823 1 347 347 CD cord-028721-x6f26ahr 824 1 The the DT cord-028721-x6f26ahr 824 2 terms term NNS cord-028721-x6f26ahr 824 3 ' ' POS cord-028721-x6f26ahr 824 4 fragile fragile JJ cord-028721-x6f26ahr 824 5 X x NN cord-028721-x6f26ahr 824 6 - - JJ cord-028721-x6f26ahr 824 7 negative negative JJ cord-028721-x6f26ahr 824 8 Martin Martin NNP cord-028721-x6f26ahr 824 9 - - HYPH cord-028721-x6f26ahr 824 10 Bell Bell NNP cord-028721-x6f26ahr 824 11 syndrome syndrome NN cord-028721-x6f26ahr 824 12 ' ' '' cord-028721-x6f26ahr 824 13 or or CC cord-028721-x6f26ahr 824 14 ' ' `` cord-028721-x6f26ahr 824 15 mental mental JJ cord-028721-x6f26ahr 824 16 retardation retardation NN cord-028721-x6f26ahr 824 17 - - HYPH cord-028721-x6f26ahr 824 18 macro macro NN cord-028721-x6f26ahr 824 19 - - HYPH cord-028721-x6f26ahr 824 20 orchidism orchidism NN cord-028721-x6f26ahr 824 21 ' ' '' cord-028721-x6f26ahr 824 22 refer refer NN cord-028721-x6f26ahr 824 23 to to IN cord-028721-x6f26ahr 824 24 X x NN cord-028721-x6f26ahr 824 25 - - VBN cord-028721-x6f26ahr 824 26 linked link VBN cord-028721-x6f26ahr 824 27 ( ( -LRB- cord-028721-x6f26ahr 824 28 MRMO MRMO NNP cord-028721-x6f26ahr 824 29 ) ) -RRB- cord-028721-x6f26ahr 824 30 or or CC cord-028721-x6f26ahr 824 31 XLMR+MO xlmr+mo CD cord-028721-x6f26ahr 824 32 patients patient NNS cord-028721-x6f26ahr 824 33 who who WP cord-028721-x6f26ahr 824 34 have have VBP cord-028721-x6f26ahr 824 35 the the DT cord-028721-x6f26ahr 824 36 Martin Martin NNP cord-028721-x6f26ahr 824 37 - - HYPH cord-028721-x6f26ahr 824 38 Bell Bell NNP cord-028721-x6f26ahr 824 39 syndrome syndrome NN cord-028721-x6f26ahr 824 40 phenotype phenotype NN cord-028721-x6f26ahr 824 41 but but CC cord-028721-x6f26ahr 824 42 do do VBP cord-028721-x6f26ahr 824 43 not not RB cord-028721-x6f26ahr 824 44 present present VB cord-028721-x6f26ahr 824 45 the the DT cord-028721-x6f26ahr 824 46 fragile fragile JJ cord-028721-x6f26ahr 824 47 X x NN cord-028721-x6f26ahr 824 48 site site NN cord-028721-x6f26ahr 824 49 . . . cord-028721-x6f26ahr 825 1 The the DT cord-028721-x6f26ahr 825 2 gene gene NN cord-028721-x6f26ahr 825 3 responsible responsible JJ cord-028721-x6f26ahr 825 4 for for IN cord-028721-x6f26ahr 825 5 this this DT cord-028721-x6f26ahr 825 6 disorder disorder NN cord-028721-x6f26ahr 825 7 is be VBZ cord-028721-x6f26ahr 825 8 mapped map VBN cord-028721-x6f26ahr 825 9 to to IN cord-028721-x6f26ahr 825 10 Xq12-q21 xq12-q21 NN cord-028721-x6f26ahr 825 11 . . . cord-028721-x6f26ahr 826 1 348 348 CD cord-028721-x6f26ahr 826 2 starts start NNS cord-028721-x6f26ahr 826 3 . . . cord-028721-x6f26ahr 827 1 353 353 CD cord-028721-x6f26ahr 827 2 , , , cord-028721-x6f26ahr 827 3 358 358 CD cord-028721-x6f26ahr 827 4 , , , cord-028721-x6f26ahr 827 5 359 359 CD cord-028721-x6f26ahr 828 1 The the DT cord-028721-x6f26ahr 828 2 etiopathogenesis etiopathogenesis NN cord-028721-x6f26ahr 828 3 has have VBZ cord-028721-x6f26ahr 828 4 been be VBN cord-028721-x6f26ahr 828 5 explained explain VBN cord-028721-x6f26ahr 828 6 by by IN cord-028721-x6f26ahr 828 7 three three CD cord-028721-x6f26ahr 828 8 hypotheses hypothesis NNS cord-028721-x6f26ahr 828 9 : : : cord-028721-x6f26ahr 828 10 an an DT cord-028721-x6f26ahr 828 11 increase increase NN cord-028721-x6f26ahr 828 12 in in IN cord-028721-x6f26ahr 828 13 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 828 14 secretion secretion NN cord-028721-x6f26ahr 828 15 caused cause VBN cord-028721-x6f26ahr 828 16 by by IN cord-028721-x6f26ahr 828 17 TRH TRH NNP cord-028721-x6f26ahr 828 18 stimulation stimulation NN cord-028721-x6f26ahr 828 19 of of IN cord-028721-x6f26ahr 828 20 gonadotropic gonadotropic NNP cord-028721-x6f26ahr 828 21 cells cell NNS cord-028721-x6f26ahr 828 22 ; ; : cord-028721-x6f26ahr 828 23 360,361 360,361 CD cord-028721-x6f26ahr 828 24 a a DT cord-028721-x6f26ahr 828 25 direct direct JJ cord-028721-x6f26ahr 828 26 TSH tsh NN cord-028721-x6f26ahr 828 27 effect effect NN cord-028721-x6f26ahr 828 28 on on IN cord-028721-x6f26ahr 828 29 the the DT cord-028721-x6f26ahr 828 30 testis testis NN cord-028721-x6f26ahr 828 31 due due IN cord-028721-x6f26ahr 828 32 to to IN cord-028721-x6f26ahr 828 33 the the DT cord-028721-x6f26ahr 828 34 structural structural JJ cord-028721-x6f26ahr 828 35 similarity similarity NN cord-028721-x6f26ahr 828 36 between between IN cord-028721-x6f26ahr 828 37 TSH TSH NNP cord-028721-x6f26ahr 828 38 receptors receptor NNS cord-028721-x6f26ahr 828 39 and and CC cord-028721-x6f26ahr 828 40 FSH fsh NN cord-028721-x6f26ahr 828 41 receptors receptor NNS cord-028721-x6f26ahr 828 42 present present JJ cord-028721-x6f26ahr 828 43 in in IN cord-028721-x6f26ahr 828 44 the the DT cord-028721-x6f26ahr 828 45 testis testis NN cord-028721-x6f26ahr 828 46 ; ; : cord-028721-x6f26ahr 828 47 362 362 CD cord-028721-x6f26ahr 828 48 and and CC cord-028721-x6f26ahr 828 49 a a DT cord-028721-x6f26ahr 828 50 lack lack NN cord-028721-x6f26ahr 828 51 of of IN cord-028721-x6f26ahr 828 52 steroid steroid NN cord-028721-x6f26ahr 828 53 hormones hormone NNS cord-028721-x6f26ahr 828 54 that that WDT cord-028721-x6f26ahr 828 55 are be VBP cord-028721-x6f26ahr 828 56 required require VBN cord-028721-x6f26ahr 828 57 for for IN cord-028721-x6f26ahr 828 58 testicular testicular JJ cord-028721-x6f26ahr 828 59 maturation maturation NN cord-028721-x6f26ahr 828 60 ( ( -LRB- cord-028721-x6f26ahr 828 61 in in IN cord-028721-x6f26ahr 828 62 their -PRON- PRP$ cord-028721-x6f26ahr 828 63 absence absence NN cord-028721-x6f26ahr 828 64 , , , cord-028721-x6f26ahr 828 65 Sertoli sertoli JJ cord-028721-x6f26ahr 828 66 cell cell NN cord-028721-x6f26ahr 828 67 proliferation proliferation NN cord-028721-x6f26ahr 828 68 is be VBZ cord-028721-x6f26ahr 828 69 excessive excessive JJ cord-028721-x6f26ahr 828 70 , , , cord-028721-x6f26ahr 828 71 giving give VBG cord-028721-x6f26ahr 828 72 rise rise NN cord-028721-x6f26ahr 828 73 to to IN cord-028721-x6f26ahr 828 74 testicular testicular JJ cord-028721-x6f26ahr 828 75 enlargement enlargement NN cord-028721-x6f26ahr 828 76 ) ) -RRB- cord-028721-x6f26ahr 828 77 . . . cord-028721-x6f26ahr 829 1 [ [ -LRB- cord-028721-x6f26ahr 829 2 363 363 CD cord-028721-x6f26ahr 829 3 ] ] -RRB- cord-028721-x6f26ahr 829 4 [ [ -LRB- cord-028721-x6f26ahr 829 5 364 364 CD cord-028721-x6f26ahr 829 6 ] ] -RRB- cord-028721-x6f26ahr 830 1 [ [ -LRB- cord-028721-x6f26ahr 830 2 365 365 CD cord-028721-x6f26ahr 830 3 ] ] -RRB- cord-028721-x6f26ahr 830 4 [ [ -LRB- cord-028721-x6f26ahr 830 5 366 366 CD cord-028721-x6f26ahr 830 6 ] ] -RRB- cord-028721-x6f26ahr 830 7 Precocious precocious JJ cord-028721-x6f26ahr 830 8 puberty puberty NN cord-028721-x6f26ahr 831 1 Precocious precocious JJ cord-028721-x6f26ahr 831 2 puberty puberty NN cord-028721-x6f26ahr 831 3 is be VBZ cord-028721-x6f26ahr 831 4 defi defi NNP cord-028721-x6f26ahr 831 5 ned ned NNP cord-028721-x6f26ahr 831 6 by by IN cord-028721-x6f26ahr 831 7 onset onset NN cord-028721-x6f26ahr 831 8 of of IN cord-028721-x6f26ahr 831 9 secondary secondary JJ cord-028721-x6f26ahr 831 10 sex sex NN cord-028721-x6f26ahr 831 11 characteristics characteristic NNS cord-028721-x6f26ahr 831 12 at at IN cord-028721-x6f26ahr 831 13 a a DT cord-028721-x6f26ahr 831 14 chronologic chronologic NN cord-028721-x6f26ahr 831 15 age age NN cord-028721-x6f26ahr 831 16 that that WDT cord-028721-x6f26ahr 831 17 is be VBZ cord-028721-x6f26ahr 831 18 below below IN cord-028721-x6f26ahr 831 19 the the DT cord-028721-x6f26ahr 831 20 mean mean JJ cord-028721-x6f26ahr 831 21 middle middle JJ cord-028721-x6f26ahr 831 22 age age NN cord-028721-x6f26ahr 831 23 for for IN cord-028721-x6f26ahr 831 24 the the DT cord-028721-x6f26ahr 831 25 population population NN cord-028721-x6f26ahr 831 26 . . . cord-028721-x6f26ahr 832 1 For for IN cord-028721-x6f26ahr 832 2 practical practical JJ cord-028721-x6f26ahr 832 3 purposes purpose NNS cord-028721-x6f26ahr 832 4 , , , cord-028721-x6f26ahr 832 5 this this DT cord-028721-x6f26ahr 832 6 is be VBZ cord-028721-x6f26ahr 832 7 considered consider VBN cord-028721-x6f26ahr 832 8 to to TO cord-028721-x6f26ahr 832 9 be be VB cord-028721-x6f26ahr 832 10 before before IN cord-028721-x6f26ahr 832 11 8 8 CD cord-028721-x6f26ahr 832 12 years year NNS cord-028721-x6f26ahr 832 13 of of IN cord-028721-x6f26ahr 832 14 age age NN cord-028721-x6f26ahr 832 15 in in IN cord-028721-x6f26ahr 832 16 girls girl NNS cord-028721-x6f26ahr 832 17 and and CC cord-028721-x6f26ahr 832 18 9 9 CD cord-028721-x6f26ahr 832 19 years year NNS cord-028721-x6f26ahr 832 20 in in IN cord-028721-x6f26ahr 832 21 boys boy NNS cord-028721-x6f26ahr 832 22 . . . cord-028721-x6f26ahr 833 1 The the DT cord-028721-x6f26ahr 833 2 incidence incidence NN cord-028721-x6f26ahr 833 3 is be VBZ cord-028721-x6f26ahr 833 4 estimated estimate VBN cord-028721-x6f26ahr 833 5 at at IN cord-028721-x6f26ahr 833 6 between between IN cord-028721-x6f26ahr 833 7 1 1 CD cord-028721-x6f26ahr 833 8 in in IN cord-028721-x6f26ahr 833 9 5000 5000 CD cord-028721-x6f26ahr 833 10 and and CC cord-028721-x6f26ahr 833 11 1 1 CD cord-028721-x6f26ahr 833 12 in in IN cord-028721-x6f26ahr 833 13 10 10 CD cord-028721-x6f26ahr 833 14 000 000 CD cord-028721-x6f26ahr 833 15 , , , cord-028721-x6f26ahr 833 16 with with IN cord-028721-x6f26ahr 833 17 a a DT cord-028721-x6f26ahr 833 18 female female JJ cord-028721-x6f26ahr 833 19 : : : cord-028721-x6f26ahr 833 20 male male JJ cord-028721-x6f26ahr 833 21 ratio ratio NN cord-028721-x6f26ahr 833 22 higher high JJR cord-028721-x6f26ahr 833 23 than than IN cord-028721-x6f26ahr 833 24 20 20 CD cord-028721-x6f26ahr 833 25 : : SYM cord-028721-x6f26ahr 833 26 1 1 CD cord-028721-x6f26ahr 833 27 . . . cord-028721-x6f26ahr 834 1 In in IN cord-028721-x6f26ahr 834 2 boys boy NNS cord-028721-x6f26ahr 834 3 , , , cord-028721-x6f26ahr 834 4 the the DT cord-028721-x6f26ahr 834 5 fi fi NN cord-028721-x6f26ahr 834 6 rst rst NN cord-028721-x6f26ahr 834 7 symptom symptom NN cord-028721-x6f26ahr 834 8 is be VBZ cord-028721-x6f26ahr 834 9 rapid rapid JJ cord-028721-x6f26ahr 834 10 testicular testicular JJ cord-028721-x6f26ahr 834 11 enlargement enlargement NN cord-028721-x6f26ahr 834 12 followed follow VBN cord-028721-x6f26ahr 834 13 by by IN cord-028721-x6f26ahr 834 14 growth growth NN cord-028721-x6f26ahr 834 15 of of IN cord-028721-x6f26ahr 834 16 pubic pubic NN cord-028721-x6f26ahr 834 17 and and CC cord-028721-x6f26ahr 834 18 axillary axillary JJ cord-028721-x6f26ahr 834 19 hair hair NN cord-028721-x6f26ahr 834 20 , , , cord-028721-x6f26ahr 834 21 enlargement enlargement NN cord-028721-x6f26ahr 834 22 of of IN cord-028721-x6f26ahr 834 23 the the DT cord-028721-x6f26ahr 834 24 penis penis NN cord-028721-x6f26ahr 834 25 , , , cord-028721-x6f26ahr 834 26 and and CC cord-028721-x6f26ahr 834 27 acceleration acceleration NN cord-028721-x6f26ahr 834 28 of of IN cord-028721-x6f26ahr 834 29 skeletal skeletal JJ cord-028721-x6f26ahr 834 30 growth growth NN cord-028721-x6f26ahr 834 31 . . . cord-028721-x6f26ahr 835 1 367 367 CD cord-028721-x6f26ahr 836 1 According accord VBG cord-028721-x6f26ahr 836 2 to to IN cord-028721-x6f26ahr 836 3 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 836 4 - - HYPH cord-028721-x6f26ahr 836 5 gonadal gonadal JJ cord-028721-x6f26ahr 836 6 axis axis NN cord-028721-x6f26ahr 836 7 function function NN cord-028721-x6f26ahr 836 8 , , , cord-028721-x6f26ahr 836 9 precocious precocious JJ cord-028721-x6f26ahr 836 10 puberty puberty NN cord-028721-x6f26ahr 836 11 can can MD cord-028721-x6f26ahr 836 12 be be VB cord-028721-x6f26ahr 836 13 classifi classifi NNP cord-028721-x6f26ahr 836 14 ed ed NN cord-028721-x6f26ahr 836 15 into into IN cord-028721-x6f26ahr 836 16 three three CD cord-028721-x6f26ahr 836 17 groups group NNS cord-028721-x6f26ahr 836 18 : : : cord-028721-x6f26ahr 836 19 central central JJ cord-028721-x6f26ahr 836 20 or or CC cord-028721-x6f26ahr 836 21 gonadotropin gonadotropin NN cord-028721-x6f26ahr 836 22 - - HYPH cord-028721-x6f26ahr 836 23 dependent dependent JJ cord-028721-x6f26ahr 836 24 , , , cord-028721-x6f26ahr 836 25 which which WDT cord-028721-x6f26ahr 836 26 results result VBZ cord-028721-x6f26ahr 836 27 from from IN cord-028721-x6f26ahr 836 28 the the DT cord-028721-x6f26ahr 836 29 activation activation NN cord-028721-x6f26ahr 836 30 of of IN cord-028721-x6f26ahr 836 31 this this DT cord-028721-x6f26ahr 836 32 axis axis NN cord-028721-x6f26ahr 836 33 ; ; : cord-028721-x6f26ahr 836 34 peripheral peripheral JJ cord-028721-x6f26ahr 836 35 or or CC cord-028721-x6f26ahr 836 36 gonadotropinindependent gonadotropinindependent NN cord-028721-x6f26ahr 836 37 , , , cord-028721-x6f26ahr 836 38 mediated mediate VBN cord-028721-x6f26ahr 836 39 by by IN cord-028721-x6f26ahr 836 40 sex sex NN cord-028721-x6f26ahr 836 41 steroid steroid NN cord-028721-x6f26ahr 836 42 hormones hormone NNS cord-028721-x6f26ahr 836 43 secreted secrete VBN cord-028721-x6f26ahr 836 44 by by IN cord-028721-x6f26ahr 836 45 the the DT cord-028721-x6f26ahr 836 46 testis testis NN cord-028721-x6f26ahr 836 47 or or CC cord-028721-x6f26ahr 836 48 adrenal adrenal JJ cord-028721-x6f26ahr 836 49 glands gland NNS cord-028721-x6f26ahr 836 50 ; ; : cord-028721-x6f26ahr 836 51 and and CC cord-028721-x6f26ahr 836 52 a a DT cord-028721-x6f26ahr 836 53 mixed mixed JJ cord-028721-x6f26ahr 836 54 group group NN cord-028721-x6f26ahr 836 55 that that WDT cord-028721-x6f26ahr 836 56 fi fi NNP cord-028721-x6f26ahr 836 57 rst rst NNP cord-028721-x6f26ahr 836 58 appears appear VBZ cord-028721-x6f26ahr 836 59 as as IN cord-028721-x6f26ahr 836 60 peripheral peripheral JJ cord-028721-x6f26ahr 836 61 precocious precocious JJ cord-028721-x6f26ahr 836 62 puberty puberty NN cord-028721-x6f26ahr 836 63 and and CC cord-028721-x6f26ahr 836 64 thereafter thereafter RB cord-028721-x6f26ahr 836 65 , , , cord-028721-x6f26ahr 836 66 because because IN cord-028721-x6f26ahr 836 67 of of IN cord-028721-x6f26ahr 836 68 the the DT cord-028721-x6f26ahr 836 69 secondary secondary JJ cord-028721-x6f26ahr 836 70 response response NN cord-028721-x6f26ahr 836 71 of of IN cord-028721-x6f26ahr 836 72 the the DT cord-028721-x6f26ahr 836 73 hypothalamus hypothalamus NN cord-028721-x6f26ahr 836 74 , , , cord-028721-x6f26ahr 836 75 becomes become VBZ cord-028721-x6f26ahr 836 76 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 836 77 dependent dependent JJ cord-028721-x6f26ahr 836 78 . . . cord-028721-x6f26ahr 837 1 Other other JJ cord-028721-x6f26ahr 837 2 possible possible JJ cord-028721-x6f26ahr 837 3 causes cause NNS cord-028721-x6f26ahr 837 4 of of IN cord-028721-x6f26ahr 837 5 precocious precocious JJ cord-028721-x6f26ahr 837 6 puberty puberty NN cord-028721-x6f26ahr 837 7 are be VBP cord-028721-x6f26ahr 837 8 hypoprolactinemia hypoprolactinemia NN cord-028721-x6f26ahr 837 9 , , , cord-028721-x6f26ahr 837 10 pituitary pituitary JJ cord-028721-x6f26ahr 837 11 tumor tumor NN cord-028721-x6f26ahr 837 12 , , , cord-028721-x6f26ahr 837 13 and and CC cord-028721-x6f26ahr 837 14 alteration alteration NN cord-028721-x6f26ahr 837 15 of of IN cord-028721-x6f26ahr 837 16 testicular testicular JJ cord-028721-x6f26ahr 837 17 steroid steroid NN cord-028721-x6f26ahr 837 18 metabolism metabolism NN cord-028721-x6f26ahr 837 19 . . . cord-028721-x6f26ahr 838 1 Central central JJ cord-028721-x6f26ahr 838 2 precocious precocious JJ cord-028721-x6f26ahr 838 3 puberty puberty NN cord-028721-x6f26ahr 838 4 ( ( -LRB- cord-028721-x6f26ahr 838 5 CPP CPP NNP cord-028721-x6f26ahr 838 6 ) ) -RRB- cord-028721-x6f26ahr 839 1 Central central JJ cord-028721-x6f26ahr 839 2 precocious precocious JJ cord-028721-x6f26ahr 839 3 puberty puberty NN cord-028721-x6f26ahr 839 4 , , , cord-028721-x6f26ahr 839 5 also also RB cord-028721-x6f26ahr 839 6 known know VBN cord-028721-x6f26ahr 839 7 as as IN cord-028721-x6f26ahr 839 8 true true JJ cord-028721-x6f26ahr 839 9 precocious precocious JJ cord-028721-x6f26ahr 839 10 puberty puberty NN cord-028721-x6f26ahr 839 11 , , , cord-028721-x6f26ahr 839 12 is be VBZ cord-028721-x6f26ahr 839 13 isosexual isosexual JJ cord-028721-x6f26ahr 839 14 . . . cord-028721-x6f26ahr 840 1 It -PRON- PRP cord-028721-x6f26ahr 840 2 is be VBZ cord-028721-x6f26ahr 840 3 the the DT cord-028721-x6f26ahr 840 4 most most RBS cord-028721-x6f26ahr 840 5 common common JJ cord-028721-x6f26ahr 840 6 form form NN cord-028721-x6f26ahr 840 7 of of IN cord-028721-x6f26ahr 840 8 precocious precocious JJ cord-028721-x6f26ahr 840 9 puberty puberty NN cord-028721-x6f26ahr 840 10 in in IN cord-028721-x6f26ahr 840 11 girls girl NNS cord-028721-x6f26ahr 840 12 and and CC cord-028721-x6f26ahr 840 13 accounts account NNS cord-028721-x6f26ahr 840 14 for for IN cord-028721-x6f26ahr 840 15 more more JJR cord-028721-x6f26ahr 840 16 than than IN cord-028721-x6f26ahr 840 17 50 50 CD cord-028721-x6f26ahr 840 18 % % NN cord-028721-x6f26ahr 840 19 of of IN cord-028721-x6f26ahr 840 20 cases case NNS cord-028721-x6f26ahr 840 21 in in IN cord-028721-x6f26ahr 840 22 boys boy NNS cord-028721-x6f26ahr 840 23 . . . cord-028721-x6f26ahr 841 1 The the DT cord-028721-x6f26ahr 841 2 age age NN cord-028721-x6f26ahr 841 3 of of IN cord-028721-x6f26ahr 841 4 presentation presentation NN cord-028721-x6f26ahr 841 5 is be VBZ cord-028721-x6f26ahr 841 6 between between IN cord-028721-x6f26ahr 841 7 4 4 CD cord-028721-x6f26ahr 841 8 and and CC cord-028721-x6f26ahr 841 9 10 10 CD cord-028721-x6f26ahr 841 10 years year NNS cord-028721-x6f26ahr 841 11 . . . cord-028721-x6f26ahr 842 1 368 368 CD cord-028721-x6f26ahr 843 1 The the DT cord-028721-x6f26ahr 843 2 cause cause NN cord-028721-x6f26ahr 843 3 is be VBZ cord-028721-x6f26ahr 843 4 only only RB cord-028721-x6f26ahr 843 5 known know VBN cord-028721-x6f26ahr 843 6 in in IN cord-028721-x6f26ahr 843 7 60 60 CD cord-028721-x6f26ahr 843 8 % % NN cord-028721-x6f26ahr 843 9 of of IN cord-028721-x6f26ahr 843 10 cases case NNS cord-028721-x6f26ahr 843 11 ; ; : cord-028721-x6f26ahr 843 12 most most JJS cord-028721-x6f26ahr 843 13 are be VBP cord-028721-x6f26ahr 843 14 related relate VBN cord-028721-x6f26ahr 843 15 to to IN cord-028721-x6f26ahr 843 16 lesions lesion NNS cord-028721-x6f26ahr 843 17 in in IN cord-028721-x6f26ahr 843 18 the the DT cord-028721-x6f26ahr 843 19 central central JJ cord-028721-x6f26ahr 843 20 nervous nervous JJ cord-028721-x6f26ahr 843 21 system system NN cord-028721-x6f26ahr 843 22 , , , cord-028721-x6f26ahr 843 23 whereas whereas IN cord-028721-x6f26ahr 843 24 the the DT cord-028721-x6f26ahr 843 25 others other NNS cord-028721-x6f26ahr 843 26 are be VBP cord-028721-x6f26ahr 843 27 usually usually RB cord-028721-x6f26ahr 843 28 idiopathic idiopathic JJ cord-028721-x6f26ahr 843 29 . . . cord-028721-x6f26ahr 844 1 Lesions lesion NNS cord-028721-x6f26ahr 844 2 in in IN cord-028721-x6f26ahr 844 3 the the DT cord-028721-x6f26ahr 844 4 central central JJ cord-028721-x6f26ahr 844 5 nervous nervous JJ cord-028721-x6f26ahr 844 6 system system NN cord-028721-x6f26ahr 844 7 that that WDT cord-028721-x6f26ahr 844 8 causes cause VBZ cord-028721-x6f26ahr 844 9 CPP CPP NNP cord-028721-x6f26ahr 844 10 share share NN cord-028721-x6f26ahr 844 11 alterations alteration NNS cord-028721-x6f26ahr 844 12 of of IN cord-028721-x6f26ahr 844 13 specifi specifi NN cord-028721-x6f26ahr 844 14 c c NN cord-028721-x6f26ahr 844 15 areas area NNS cord-028721-x6f26ahr 844 16 , , , cord-028721-x6f26ahr 844 17 including include VBG cord-028721-x6f26ahr 844 18 the the DT cord-028721-x6f26ahr 844 19 posterior posterior JJ cord-028721-x6f26ahr 844 20 hypothalamus hypothalamus NN cord-028721-x6f26ahr 844 21 ( ( -LRB- cord-028721-x6f26ahr 844 22 eminencia eminencia NNP cord-028721-x6f26ahr 844 23 media medium NNS cord-028721-x6f26ahr 844 24 and and CC cord-028721-x6f26ahr 844 25 tuber tuber NN cord-028721-x6f26ahr 844 26 cinereum cinereum NNP cord-028721-x6f26ahr 844 27 ) ) -RRB- cord-028721-x6f26ahr 844 28 , , , cord-028721-x6f26ahr 844 29 mammillary mammillary JJ cord-028721-x6f26ahr 844 30 bodies body NNS cord-028721-x6f26ahr 844 31 , , , cord-028721-x6f26ahr 844 32 the the DT cord-028721-x6f26ahr 844 33 bottom bottom NN cord-028721-x6f26ahr 844 34 of of IN cord-028721-x6f26ahr 844 35 the the DT cord-028721-x6f26ahr 844 36 third third JJ cord-028721-x6f26ahr 844 37 ventricle ventricle NN cord-028721-x6f26ahr 844 38 , , , cord-028721-x6f26ahr 844 39 or or CC cord-028721-x6f26ahr 844 40 the the DT cord-028721-x6f26ahr 844 41 pineal pineal NN cord-028721-x6f26ahr 844 42 gland gland NN cord-028721-x6f26ahr 844 43 . . . cord-028721-x6f26ahr 845 1 369 369 CD cord-028721-x6f26ahr 845 2 _SP cord-028721-x6f26ahr 846 1 Testicular testicular JJ cord-028721-x6f26ahr 846 2 hypertrophy hypertrophy NN cord-028721-x6f26ahr 846 3 appears appear VBZ cord-028721-x6f26ahr 846 4 associated associate VBN cord-028721-x6f26ahr 846 5 with with IN cord-028721-x6f26ahr 846 6 FSH fsh NN cord-028721-x6f26ahr 846 7 - - HYPH cord-028721-x6f26ahr 846 8 secreting secrete VBG cord-028721-x6f26ahr 846 9 pituitary pituitary JJ cord-028721-x6f26ahr 846 10 adenoma adenoma NN cord-028721-x6f26ahr 846 11 , , , cord-028721-x6f26ahr 846 12 349 349 CD cord-028721-x6f26ahr 846 13 hyperprolactinemia hyperprolactinemia NN cord-028721-x6f26ahr 846 14 , , , cord-028721-x6f26ahr 846 15 hypoprolactinemia hypoprolactinemia NN cord-028721-x6f26ahr 846 16 , , , cord-028721-x6f26ahr 846 17 and and CC cord-028721-x6f26ahr 846 18 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 846 19 . . . cord-028721-x6f26ahr 847 1 350 350 CD cord-028721-x6f26ahr 847 2 , , , cord-028721-x6f26ahr 847 3 351 351 CD cord-028721-x6f26ahr 847 4 The the DT cord-028721-x6f26ahr 847 5 most most RBS cord-028721-x6f26ahr 847 6 frequent frequent JJ cord-028721-x6f26ahr 847 7 association association NN cord-028721-x6f26ahr 847 8 of of IN cord-028721-x6f26ahr 847 9 testicular testicular JJ cord-028721-x6f26ahr 847 10 hypertrophy hypertrophy NN cord-028721-x6f26ahr 847 11 is be VBZ cord-028721-x6f26ahr 847 12 with with IN cord-028721-x6f26ahr 847 13 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 847 14 . . . cord-028721-x6f26ahr 848 1 Children child NNS cord-028721-x6f26ahr 848 2 with with IN cord-028721-x6f26ahr 848 3 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 848 4 often often RB cord-028721-x6f26ahr 848 5 show show VBP cord-028721-x6f26ahr 848 6 testicular testicular JJ cord-028721-x6f26ahr 848 7 enlargement enlargement NN cord-028721-x6f26ahr 848 8 without without IN cord-028721-x6f26ahr 848 9 virilization virilization NN cord-028721-x6f26ahr 848 10 . . . cord-028721-x6f26ahr 849 1 350 350 CD cord-028721-x6f26ahr 849 2 About about RB cord-028721-x6f26ahr 849 3 80 80 CD cord-028721-x6f26ahr 849 4 % % NN cord-028721-x6f26ahr 849 5 have have VBP cord-028721-x6f26ahr 849 6 macroorchidism macroorchidism NN cord-028721-x6f26ahr 849 7 , , , cord-028721-x6f26ahr 849 8 352 352 CD cord-028721-x6f26ahr 849 9 most most JJS cord-028721-x6f26ahr 849 10 have have VBP cord-028721-x6f26ahr 849 11 elevated elevate VBN cord-028721-x6f26ahr 849 12 FSH fsh NN cord-028721-x6f26ahr 849 13 levels level NNS cord-028721-x6f26ahr 849 14 , , , cord-028721-x6f26ahr 849 15 and and CC cord-028721-x6f26ahr 849 16 half half NN cord-028721-x6f26ahr 849 17 have have VBP cord-028721-x6f26ahr 849 18 increased increase VBN cord-028721-x6f26ahr 849 19 LH LH NNP cord-028721-x6f26ahr 849 20 levels level NNS cord-028721-x6f26ahr 849 21 . . . cord-028721-x6f26ahr 850 1 353 353 CD cord-028721-x6f26ahr 850 2 , , , cord-028721-x6f26ahr 850 3 354 354 CD cord-028721-x6f26ahr 850 4 Testosterone testosterone NN cord-028721-x6f26ahr 850 5 levels level NNS cord-028721-x6f26ahr 850 6 are be VBP cord-028721-x6f26ahr 850 7 normal normal JJ cord-028721-x6f26ahr 850 8 during during IN cord-028721-x6f26ahr 850 9 infancy infancy NN cord-028721-x6f26ahr 850 10 . . . cord-028721-x6f26ahr 851 1 The the DT cord-028721-x6f26ahr 851 2 response response NN cord-028721-x6f26ahr 851 3 of of IN cord-028721-x6f26ahr 851 4 FSH FSH NNP cord-028721-x6f26ahr 851 5 and and CC cord-028721-x6f26ahr 851 6 LH LH NNP cord-028721-x6f26ahr 851 7 to to IN cord-028721-x6f26ahr 851 8 GnRH GnRH NNP cord-028721-x6f26ahr 851 9 is be VBZ cord-028721-x6f26ahr 851 10 altered alter VBN cord-028721-x6f26ahr 851 11 and and CC cord-028721-x6f26ahr 851 12 no no DT cord-028721-x6f26ahr 851 13 pulsatile pulsatile JJ cord-028721-x6f26ahr 851 14 LH lh NN cord-028721-x6f26ahr 851 15 release release NN cord-028721-x6f26ahr 851 16 occurs occur VBZ cord-028721-x6f26ahr 851 17 ( ( -LRB- cord-028721-x6f26ahr 851 18 Fig Fig NNP cord-028721-x6f26ahr 851 19 . . . cord-028721-x6f26ahr 851 20 12 12 CD cord-028721-x6f26ahr 851 21 - - SYM cord-028721-x6f26ahr 851 22 34 34 CD cord-028721-x6f26ahr 851 23 ) ) -RRB- cord-028721-x6f26ahr 851 24 . . . cord-028721-x6f26ahr 852 1 355 355 CD cord-028721-x6f26ahr 852 2 Testicular Testicular NNP cord-028721-x6f26ahr 852 3 biopsies biopsy NNS cord-028721-x6f26ahr 852 4 before before IN cord-028721-x6f26ahr 852 5 puberty puberty NNS cord-028721-x6f26ahr 852 6 show show VBP cord-028721-x6f26ahr 852 7 an an DT cord-028721-x6f26ahr 852 8 accelerated accelerate VBN cord-028721-x6f26ahr 852 9 development development NN cord-028721-x6f26ahr 852 10 of of IN cord-028721-x6f26ahr 852 11 the the DT cord-028721-x6f26ahr 852 12 testis testis NN cord-028721-x6f26ahr 852 13 with with IN cord-028721-x6f26ahr 852 14 pubertal pubertal JJ cord-028721-x6f26ahr 852 15 maturation maturation NN cord-028721-x6f26ahr 852 16 of of IN cord-028721-x6f26ahr 852 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 852 18 tubules tubule NNS cord-028721-x6f26ahr 852 19 but but CC cord-028721-x6f26ahr 852 20 not not RB cord-028721-x6f26ahr 852 21 Leydig leydig NN cord-028721-x6f26ahr 852 22 cells cell NNS cord-028721-x6f26ahr 852 23 . . . cord-028721-x6f26ahr 853 1 Testicular testicular JJ cord-028721-x6f26ahr 853 2 biopsies biopsy NNS cord-028721-x6f26ahr 853 3 in in IN cord-028721-x6f26ahr 853 4 untreated untreated JJ cord-028721-x6f26ahr 853 5 adults adult NNS cord-028721-x6f26ahr 853 6 show show VBP cord-028721-x6f26ahr 853 7 tubular tubular JJ cord-028721-x6f26ahr 853 8 and and CC cord-028721-x6f26ahr 853 9 interstitial interstitial JJ cord-028721-x6f26ahr 853 10 hyalinization hyalinization NN cord-028721-x6f26ahr 853 11 with with IN cord-028721-x6f26ahr 853 12 few few JJ cord-028721-x6f26ahr 853 13 Leydig Leydig NNP cord-028721-x6f26ahr 853 14 cells cell NNS cord-028721-x6f26ahr 853 15 . . . cord-028721-x6f26ahr 854 1 356 356 CD cord-028721-x6f26ahr 854 2 , , , cord-028721-x6f26ahr 854 3 357 357 CD cord-028721-x6f26ahr 854 4 Testicular Testicular NNP cord-028721-x6f26ahr 854 5 size size NN cord-028721-x6f26ahr 854 6 in in IN cord-028721-x6f26ahr 854 7 this this DT cord-028721-x6f26ahr 854 8 type type NN cord-028721-x6f26ahr 854 9 of of IN cord-028721-x6f26ahr 854 10 macroorchidism macroorchidism NN cord-028721-x6f26ahr 854 11 diminishes diminish VBZ cord-028721-x6f26ahr 854 12 as as RB cord-028721-x6f26ahr 854 13 soon soon RB cord-028721-x6f26ahr 854 14 as as IN cord-028721-x6f26ahr 854 15 the the DT cord-028721-x6f26ahr 854 16 substitutive substitutive JJ cord-028721-x6f26ahr 854 17 therapy therapy NN cord-028721-x6f26ahr 854 18 • • NNP cord-028721-x6f26ahr 855 1 Hereditary hereditary JJ cord-028721-x6f26ahr 855 2 diseases disease NNS cord-028721-x6f26ahr 855 3 as as IN cord-028721-x6f26ahr 855 4 neurofi neurofi NNP cord-028721-x6f26ahr 855 5 bromatosis bromatosis NNP cord-028721-x6f26ahr 855 6 and and CC cord-028721-x6f26ahr 855 7 tuberous tuberous JJ cord-028721-x6f26ahr 855 8 sclerosis sclerosis NN cord-028721-x6f26ahr 855 9 . . . cord-028721-x6f26ahr 856 1 Children child NNS cord-028721-x6f26ahr 856 2 with with IN cord-028721-x6f26ahr 856 3 type type NN cord-028721-x6f26ahr 857 1 I -PRON- PRP cord-028721-x6f26ahr 857 2 neurofi neurofi VBP cord-028721-x6f26ahr 857 3 bromatosis bromatosis NNP cord-028721-x6f26ahr 857 4 often often RB cord-028721-x6f26ahr 857 5 have have VBP cord-028721-x6f26ahr 857 6 also also RB cord-028721-x6f26ahr 857 7 optic optic JJ cord-028721-x6f26ahr 857 8 pathway pathway NN cord-028721-x6f26ahr 857 9 tumors tumor NNS cord-028721-x6f26ahr 857 10 . . . cord-028721-x6f26ahr 858 1 • • NNP cord-028721-x6f26ahr 859 1 Cerebral cerebral JJ cord-028721-x6f26ahr 859 2 irradiation irradiation NN cord-028721-x6f26ahr 859 3 , , , cord-028721-x6f26ahr 859 4 as as IN cord-028721-x6f26ahr 859 5 occurs occur VBZ cord-028721-x6f26ahr 859 6 in in IN cord-028721-x6f26ahr 859 7 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 859 8 selective selective JJ cord-028721-x6f26ahr 859 9 irradiation irradiation NN cord-028721-x6f26ahr 859 10 , , , cord-028721-x6f26ahr 859 11 378 378 CD cord-028721-x6f26ahr 859 12 prophylactic prophylactic JJ cord-028721-x6f26ahr 859 13 irradiation irradiation NN cord-028721-x6f26ahr 859 14 in in IN cord-028721-x6f26ahr 859 15 children child NNS cord-028721-x6f26ahr 859 16 with with IN cord-028721-x6f26ahr 859 17 acute acute JJ cord-028721-x6f26ahr 859 18 lymphoblastic lymphoblastic JJ cord-028721-x6f26ahr 859 19 leukemia leukemia NN cord-028721-x6f26ahr 859 20 , , , cord-028721-x6f26ahr 859 21 379 379 CD cord-028721-x6f26ahr 859 22 and and CC cord-028721-x6f26ahr 859 23 irradiation irradiation NN cord-028721-x6f26ahr 859 24 of of IN cord-028721-x6f26ahr 859 25 cerebral cerebral JJ cord-028721-x6f26ahr 859 26 tumor tumor NN cord-028721-x6f26ahr 859 27 that that WDT cord-028721-x6f26ahr 859 28 is be VBZ cord-028721-x6f26ahr 859 29 far far RB cord-028721-x6f26ahr 859 30 from from IN cord-028721-x6f26ahr 859 31 the the DT cord-028721-x6f26ahr 859 32 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 859 33 region region NN cord-028721-x6f26ahr 859 34 . . . cord-028721-x6f26ahr 860 1 The the DT cord-028721-x6f26ahr 860 2 diagnosis diagnosis NN cord-028721-x6f26ahr 860 3 of of IN cord-028721-x6f26ahr 860 4 central central JJ cord-028721-x6f26ahr 860 5 precocious precocious JJ cord-028721-x6f26ahr 860 6 puberty puberty NN cord-028721-x6f26ahr 860 7 is be VBZ cord-028721-x6f26ahr 860 8 easy easy JJ cord-028721-x6f26ahr 860 9 if if IN cord-028721-x6f26ahr 860 10 the the DT cord-028721-x6f26ahr 860 11 hormonal hormonal JJ cord-028721-x6f26ahr 860 12 fi fi NNP cord-028721-x6f26ahr 860 13 ndings nding NNS cord-028721-x6f26ahr 860 14 show show VBP cord-028721-x6f26ahr 860 15 elevated elevated JJ cord-028721-x6f26ahr 860 16 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 860 17 levels level NNS cord-028721-x6f26ahr 860 18 ( ( -LRB- cord-028721-x6f26ahr 860 19 both both DT cord-028721-x6f26ahr 860 20 basal basal JJ cord-028721-x6f26ahr 860 21 values value NNS cord-028721-x6f26ahr 860 22 and and CC cord-028721-x6f26ahr 860 23 in in IN cord-028721-x6f26ahr 860 24 response response NN cord-028721-x6f26ahr 860 25 to to IN cord-028721-x6f26ahr 860 26 GnRH GnRH NNP cord-028721-x6f26ahr 860 27 ) ) -RRB- cord-028721-x6f26ahr 860 28 , , , cord-028721-x6f26ahr 860 29 associated associate VBN cord-028721-x6f26ahr 860 30 with with IN cord-028721-x6f26ahr 860 31 high high JJ cord-028721-x6f26ahr 860 32 testosterone testosterone NN cord-028721-x6f26ahr 860 33 levels level NNS cord-028721-x6f26ahr 860 34 and and CC cord-028721-x6f26ahr 860 35 an an DT cord-028721-x6f26ahr 860 36 increase increase NN cord-028721-x6f26ahr 860 37 in in IN cord-028721-x6f26ahr 860 38 either either DT cord-028721-x6f26ahr 860 39 LH LH NNP cord-028721-x6f26ahr 860 40 / / SYM cord-028721-x6f26ahr 860 41 FSH fsh NN cord-028721-x6f26ahr 860 42 ratio ratio NN cord-028721-x6f26ahr 860 43 or or CC cord-028721-x6f26ahr 860 44 in in IN cord-028721-x6f26ahr 860 45 LH LH NNP cord-028721-x6f26ahr 860 46 and and CC cord-028721-x6f26ahr 860 47 FSH fsh NN cord-028721-x6f26ahr 860 48 values value NNS cord-028721-x6f26ahr 860 49 after after IN cord-028721-x6f26ahr 860 50 stimulation stimulation NN cord-028721-x6f26ahr 860 51 with with IN cord-028721-x6f26ahr 860 52 GnRH GnRH NNP cord-028721-x6f26ahr 860 53 agonists agonist NNS cord-028721-x6f26ahr 860 54 . . . cord-028721-x6f26ahr 861 1 However however RB cord-028721-x6f26ahr 861 2 , , , cord-028721-x6f26ahr 861 3 in in IN cord-028721-x6f26ahr 861 4 some some DT cord-028721-x6f26ahr 861 5 cases case NNS cord-028721-x6f26ahr 861 6 it -PRON- PRP cord-028721-x6f26ahr 861 7 is be VBZ cord-028721-x6f26ahr 861 8 necessary necessary JJ cord-028721-x6f26ahr 861 9 to to TO cord-028721-x6f26ahr 861 10 measure measure VB cord-028721-x6f26ahr 861 11 nocturnal nocturnal JJ cord-028721-x6f26ahr 861 12 LH LH NNP cord-028721-x6f26ahr 861 13 secretion secretion NN cord-028721-x6f26ahr 861 14 to to IN cord-028721-x6f26ahr 861 15 fi fi NN cord-028721-x6f26ahr 861 16 nd nd NNP cord-028721-x6f26ahr 861 17 secretion secretion NN cord-028721-x6f26ahr 861 18 pulses pulse NNS cord-028721-x6f26ahr 861 19 before before IN cord-028721-x6f26ahr 861 20 a a DT cord-028721-x6f26ahr 861 21 dynamic dynamic JJ cord-028721-x6f26ahr 861 22 test test NN cord-028721-x6f26ahr 861 23 can can MD cord-028721-x6f26ahr 861 24 reveal reveal VB cord-028721-x6f26ahr 861 25 the the DT cord-028721-x6f26ahr 861 26 pubertal pubertal JJ cord-028721-x6f26ahr 861 27 pattern pattern NN cord-028721-x6f26ahr 861 28 . . . cord-028721-x6f26ahr 862 1 Knowledge knowledge NN cord-028721-x6f26ahr 862 2 of of IN cord-028721-x6f26ahr 862 3 the the DT cord-028721-x6f26ahr 862 4 etiology etiology NN cord-028721-x6f26ahr 862 5 in in IN cord-028721-x6f26ahr 862 6 males male NNS cord-028721-x6f26ahr 862 7 has have VBZ cord-028721-x6f26ahr 862 8 improved improve VBN cord-028721-x6f26ahr 862 9 with with IN cord-028721-x6f26ahr 862 10 the the DT cord-028721-x6f26ahr 862 11 use use NN cord-028721-x6f26ahr 862 12 of of IN cord-028721-x6f26ahr 862 13 CT CT NNP cord-028721-x6f26ahr 862 14 and and CC cord-028721-x6f26ahr 862 15 MRI MRI NNP cord-028721-x6f26ahr 862 16 . . . cord-028721-x6f26ahr 863 1 380 380 CD cord-028721-x6f26ahr 863 2 , , , cord-028721-x6f26ahr 863 3 381 381 CD cord-028721-x6f26ahr 863 4 One one CD cord-028721-x6f26ahr 863 5 of of IN cord-028721-x6f26ahr 863 6 the the DT cord-028721-x6f26ahr 863 7 most most RBS cord-028721-x6f26ahr 863 8 important important JJ cord-028721-x6f26ahr 863 9 contributions contribution NNS cord-028721-x6f26ahr 863 10 of of IN cord-028721-x6f26ahr 863 11 these these DT cord-028721-x6f26ahr 863 12 techniques technique NNS cord-028721-x6f26ahr 863 13 is be VBZ cord-028721-x6f26ahr 863 14 the the DT cord-028721-x6f26ahr 863 15 fi fi NNP cord-028721-x6f26ahr 863 16 nding nding NN cord-028721-x6f26ahr 863 17 of of IN cord-028721-x6f26ahr 863 18 a a DT cord-028721-x6f26ahr 863 19 high high JJ cord-028721-x6f26ahr 863 20 number number NN cord-028721-x6f26ahr 863 21 of of IN cord-028721-x6f26ahr 863 22 hamartomas hamartomas NNP cord-028721-x6f26ahr 863 23 in in IN cord-028721-x6f26ahr 863 24 children child NNS cord-028721-x6f26ahr 863 25 with with IN cord-028721-x6f26ahr 863 26 precocious precocious JJ cord-028721-x6f26ahr 863 27 puberty puberty NN cord-028721-x6f26ahr 863 28 . . . cord-028721-x6f26ahr 864 1 [ [ -LRB- cord-028721-x6f26ahr 864 2 382 382 CD cord-028721-x6f26ahr 864 3 ] ] -RRB- cord-028721-x6f26ahr 864 4 [ [ -LRB- cord-028721-x6f26ahr 864 5 383 383 CD cord-028721-x6f26ahr 864 6 ] ] -RRB- cord-028721-x6f26ahr 864 7 [ [ -LRB- cord-028721-x6f26ahr 864 8 384 384 CD cord-028721-x6f26ahr 864 9 ] ] -RRB- cord-028721-x6f26ahr 865 1 These these DT cord-028721-x6f26ahr 865 2 lesions lesion NNS cord-028721-x6f26ahr 865 3 , , , cord-028721-x6f26ahr 865 4 also also RB cord-028721-x6f26ahr 865 5 known know VBN cord-028721-x6f26ahr 865 6 as as IN cord-028721-x6f26ahr 865 7 gangliocytomas gangliocytomas NNP cord-028721-x6f26ahr 865 8 , , , cord-028721-x6f26ahr 865 9 consist consist VBP cord-028721-x6f26ahr 865 10 of of IN cord-028721-x6f26ahr 865 11 abnormally abnormally RB cord-028721-x6f26ahr 865 12 located locate VBN cord-028721-x6f26ahr 865 13 neurons neuron NNS cord-028721-x6f26ahr 865 14 and and CC cord-028721-x6f26ahr 865 15 glial glial JJ cord-028721-x6f26ahr 865 16 cells cell NNS cord-028721-x6f26ahr 865 17 . . . cord-028721-x6f26ahr 866 1 Lesions lesion NNS cord-028721-x6f26ahr 866 2 are be VBP cord-028721-x6f26ahr 866 3 usually usually RB cord-028721-x6f26ahr 866 4 multiple multiple JJ cord-028721-x6f26ahr 866 5 , , , cord-028721-x6f26ahr 866 6 small small JJ cord-028721-x6f26ahr 866 7 , , , cord-028721-x6f26ahr 866 8 and and CC cord-028721-x6f26ahr 866 9 located locate VBN cord-028721-x6f26ahr 866 10 on on IN cord-028721-x6f26ahr 866 11 the the DT cord-028721-x6f26ahr 866 12 hypothalamus hypothalamus NN cord-028721-x6f26ahr 866 13 between between IN cord-028721-x6f26ahr 866 14 the the DT cord-028721-x6f26ahr 866 15 anterior anterior JJ cord-028721-x6f26ahr 866 16 part part NN cord-028721-x6f26ahr 866 17 of of IN cord-028721-x6f26ahr 866 18 the the DT cord-028721-x6f26ahr 866 19 mammillary mammillary JJ cord-028721-x6f26ahr 866 20 body body NN cord-028721-x6f26ahr 866 21 and and CC cord-028721-x6f26ahr 866 22 the the DT cord-028721-x6f26ahr 866 23 posterior posterior JJ cord-028721-x6f26ahr 866 24 part part NN cord-028721-x6f26ahr 866 25 of of IN cord-028721-x6f26ahr 866 26 the the DT cord-028721-x6f26ahr 866 27 tuber tuber NN cord-028721-x6f26ahr 866 28 cinereum cinereum NN cord-028721-x6f26ahr 866 29 . . . cord-028721-x6f26ahr 867 1 These these DT cord-028721-x6f26ahr 867 2 neurons neuron NNS cord-028721-x6f26ahr 867 3 contain contain VBP cord-028721-x6f26ahr 867 4 LHRH LHRH NNP cord-028721-x6f26ahr 867 5 - - HYPH cord-028721-x6f26ahr 867 6 positive positive JJ cord-028721-x6f26ahr 867 7 neurosecretory neurosecretory NN cord-028721-x6f26ahr 867 8 granules granule NNS cord-028721-x6f26ahr 867 9 , , , cord-028721-x6f26ahr 867 10 suggesting suggest VBG cord-028721-x6f26ahr 867 11 that that IN cord-028721-x6f26ahr 867 12 this this DT cord-028721-x6f26ahr 867 13 hormone hormone NN cord-028721-x6f26ahr 867 14 can can MD cord-028721-x6f26ahr 867 15 be be VB cord-028721-x6f26ahr 867 16 released release VBN cord-028721-x6f26ahr 867 17 into into IN cord-028721-x6f26ahr 867 18 the the DT cord-028721-x6f26ahr 867 19 blood blood NN cord-028721-x6f26ahr 867 20 draining drain VBG cord-028721-x6f26ahr 867 21 the the DT cord-028721-x6f26ahr 867 22 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 867 23 portal portal NNP cord-028721-x6f26ahr 867 24 system system NN cord-028721-x6f26ahr 867 25 and and CC cord-028721-x6f26ahr 867 26 reach reach VB cord-028721-x6f26ahr 867 27 the the DT cord-028721-x6f26ahr 867 28 gonadotropic gonadotropic NNP cord-028721-x6f26ahr 867 29 cells cell NNS cord-028721-x6f26ahr 867 30 . . . cord-028721-x6f26ahr 868 1 385 385 CD cord-028721-x6f26ahr 868 2 Precocious precocious JJ cord-028721-x6f26ahr 868 3 puberty puberty NN cord-028721-x6f26ahr 868 4 owing owe VBG cord-028721-x6f26ahr 868 5 to to IN cord-028721-x6f26ahr 868 6 cerebral cerebral JJ cord-028721-x6f26ahr 868 7 tumors tumor NNS cord-028721-x6f26ahr 868 8 usually usually RB cord-028721-x6f26ahr 868 9 occurs occur VBZ cord-028721-x6f26ahr 868 10 with with IN cord-028721-x6f26ahr 868 11 advanced advanced JJ cord-028721-x6f26ahr 868 12 stage stage NN cord-028721-x6f26ahr 868 13 of of IN cord-028721-x6f26ahr 868 14 the the DT cord-028721-x6f26ahr 868 15 tumor tumor NN cord-028721-x6f26ahr 868 16 , , , cord-028721-x6f26ahr 868 17 preceded precede VBN cord-028721-x6f26ahr 868 18 by by IN cord-028721-x6f26ahr 868 19 cerebral cerebral JJ cord-028721-x6f26ahr 868 20 symptoms symptom NNS cord-028721-x6f26ahr 868 21 such such JJ cord-028721-x6f26ahr 868 22 as as IN cord-028721-x6f26ahr 868 23 hydrocephaly hydrocephaly NNP cord-028721-x6f26ahr 868 24 , , , cord-028721-x6f26ahr 868 25 papillary papillary JJ cord-028721-x6f26ahr 868 26 edema edema NN cord-028721-x6f26ahr 868 27 , , , cord-028721-x6f26ahr 868 28 or or CC cord-028721-x6f26ahr 868 29 psychic psychic JJ cord-028721-x6f26ahr 868 30 alterations alteration NNS cord-028721-x6f26ahr 868 31 . . . cord-028721-x6f26ahr 869 1 The the DT cord-028721-x6f26ahr 869 2 same same JJ cord-028721-x6f26ahr 869 3 occurs occur VBZ cord-028721-x6f26ahr 869 4 when when WRB cord-028721-x6f26ahr 869 5 precocious precocious JJ cord-028721-x6f26ahr 869 6 puberty puberty NN cord-028721-x6f26ahr 869 7 results result NNS cord-028721-x6f26ahr 869 8 from from IN cord-028721-x6f26ahr 869 9 cerebral cerebral JJ cord-028721-x6f26ahr 869 10 infl infl NN cord-028721-x6f26ahr 869 11 ammation ammation NNP cord-028721-x6f26ahr 869 12 or or CC cord-028721-x6f26ahr 869 13 cerebral cerebral JJ cord-028721-x6f26ahr 869 14 malformation malformation NN cord-028721-x6f26ahr 869 15 . . . cord-028721-x6f26ahr 870 1 Although although IN cord-028721-x6f26ahr 870 2 pineal pineal NN cord-028721-x6f26ahr 870 3 gland gland NN cord-028721-x6f26ahr 870 4 tumor tumor NN cord-028721-x6f26ahr 870 5 is be VBZ cord-028721-x6f26ahr 870 6 rare rare JJ cord-028721-x6f26ahr 870 7 in in IN cord-028721-x6f26ahr 870 8 children child NNS cord-028721-x6f26ahr 870 9 , , , cord-028721-x6f26ahr 870 10 30 30 CD cord-028721-x6f26ahr 870 11 % % NN cord-028721-x6f26ahr 870 12 produce produce VBP cord-028721-x6f26ahr 870 13 precocious precocious JJ cord-028721-x6f26ahr 870 14 puberty puberty NN cord-028721-x6f26ahr 870 15 , , , cord-028721-x6f26ahr 870 16 principally principally RB cord-028721-x6f26ahr 870 17 in in IN cord-028721-x6f26ahr 870 18 boys boy NNS cord-028721-x6f26ahr 870 19 . . . cord-028721-x6f26ahr 871 1 This this DT cord-028721-x6f26ahr 871 2 tumor tumor NN cord-028721-x6f26ahr 871 3 is be VBZ cord-028721-x6f26ahr 871 4 usually usually RB cord-028721-x6f26ahr 871 5 a a DT cord-028721-x6f26ahr 871 6 teratoma teratoma NN cord-028721-x6f26ahr 871 7 or or CC cord-028721-x6f26ahr 871 8 non non JJ cord-028721-x6f26ahr 871 9 - - JJ cord-028721-x6f26ahr 871 10 parenchymatous parenchymatous JJ cord-028721-x6f26ahr 871 11 tumor tumor NN cord-028721-x6f26ahr 871 12 that that WDT cord-028721-x6f26ahr 871 13 destroys destroy VBZ cord-028721-x6f26ahr 871 14 the the DT cord-028721-x6f26ahr 871 15 pineal pineal NN cord-028721-x6f26ahr 871 16 gland gland NN cord-028721-x6f26ahr 871 17 , , , cord-028721-x6f26ahr 871 18 hindering hinder VBG cord-028721-x6f26ahr 871 19 its -PRON- PRP$ cord-028721-x6f26ahr 871 20 antigonadotropic antigonadotropic JJ cord-028721-x6f26ahr 871 21 action action NN cord-028721-x6f26ahr 871 22 and and CC cord-028721-x6f26ahr 871 23 initiating initiate VBG cord-028721-x6f26ahr 871 24 puberty puberty NN cord-028721-x6f26ahr 871 25 . . . cord-028721-x6f26ahr 872 1 386 386 CD cord-028721-x6f26ahr 873 1 In in IN cord-028721-x6f26ahr 873 2 contrast contrast NN cord-028721-x6f26ahr 873 3 , , , cord-028721-x6f26ahr 873 4 pinealocytederived pinealocytederived JJ cord-028721-x6f26ahr 873 5 tumor tumor NN cord-028721-x6f26ahr 873 6 secretes secrete VBZ cord-028721-x6f26ahr 873 7 great great JJ cord-028721-x6f26ahr 873 8 amounts amount NNS cord-028721-x6f26ahr 873 9 of of IN cord-028721-x6f26ahr 873 10 melatonin melatonin NN cord-028721-x6f26ahr 873 11 that that WDT cord-028721-x6f26ahr 873 12 delay delay VBP cord-028721-x6f26ahr 873 13 the the DT cord-028721-x6f26ahr 873 14 onset onset NN cord-028721-x6f26ahr 873 15 of of IN cord-028721-x6f26ahr 873 16 puberty puberty NN cord-028721-x6f26ahr 873 17 . . . cord-028721-x6f26ahr 874 1 Peripheral peripheral JJ cord-028721-x6f26ahr 874 2 precocious precocious JJ cord-028721-x6f26ahr 874 3 puberty puberty NN cord-028721-x6f26ahr 874 4 ( ( -LRB- cord-028721-x6f26ahr 874 5 PPP PPP NNP cord-028721-x6f26ahr 874 6 ) ) -RRB- cord-028721-x6f26ahr 874 7 Peripheral peripheral JJ cord-028721-x6f26ahr 874 8 precocious precocious JJ cord-028721-x6f26ahr 874 9 puberty puberty NN cord-028721-x6f26ahr 874 10 is be VBZ cord-028721-x6f26ahr 874 11 also also RB cord-028721-x6f26ahr 874 12 known know VBN cord-028721-x6f26ahr 874 13 as as IN cord-028721-x6f26ahr 874 14 precocious precocious JJ cord-028721-x6f26ahr 874 15 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 874 16 . . . cord-028721-x6f26ahr 875 1 It -PRON- PRP cord-028721-x6f26ahr 875 2 may may MD cord-028721-x6f26ahr 875 3 be be VB cord-028721-x6f26ahr 875 4 caused cause VBN cord-028721-x6f26ahr 875 5 by by IN cord-028721-x6f26ahr 875 6 a a DT cord-028721-x6f26ahr 875 7 primary primary JJ cord-028721-x6f26ahr 875 8 testicular testicular JJ cord-028721-x6f26ahr 875 9 disorder disorder NN cord-028721-x6f26ahr 875 10 , , , cord-028721-x6f26ahr 875 11 a a DT cord-028721-x6f26ahr 875 12 lesion lesion NN cord-028721-x6f26ahr 875 13 in in IN cord-028721-x6f26ahr 875 14 other other JJ cord-028721-x6f26ahr 875 15 endocrine endocrine JJ cord-028721-x6f26ahr 875 16 glands gland NNS cord-028721-x6f26ahr 875 17 , , , cord-028721-x6f26ahr 875 18 or or CC cord-028721-x6f26ahr 875 19 hormonal hormonal JJ cord-028721-x6f26ahr 875 20 treatment treatment NN cord-028721-x6f26ahr 875 21 . . . cord-028721-x6f26ahr 876 1 Primary primary JJ cord-028721-x6f26ahr 876 2 testicular testicular JJ cord-028721-x6f26ahr 876 3 disorders disorder NNS cord-028721-x6f26ahr 876 4 causing cause VBG cord-028721-x6f26ahr 876 5 precocious precocious JJ cord-028721-x6f26ahr 876 6 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 876 7 include include VBP cord-028721-x6f26ahr 876 8 familial familial JJ cord-028721-x6f26ahr 876 9 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 876 10 , , , cord-028721-x6f26ahr 876 11 functioning function VBG cord-028721-x6f26ahr 876 12 testicular testicular JJ cord-028721-x6f26ahr 876 13 tumor tumor NN cord-028721-x6f26ahr 876 14 , , , cord-028721-x6f26ahr 876 15 excessive excessive JJ cord-028721-x6f26ahr 876 16 aromatase aromatase NN cord-028721-x6f26ahr 876 17 activity activity NN cord-028721-x6f26ahr 876 18 , , , cord-028721-x6f26ahr 876 19 or or CC cord-028721-x6f26ahr 876 20 Leydig Leydig NNP cord-028721-x6f26ahr 876 21 cell cell NN cord-028721-x6f26ahr 876 22 hyperplasia hyperplasia NN cord-028721-x6f26ahr 876 23 with with IN cord-028721-x6f26ahr 876 24 focal focal JJ cord-028721-x6f26ahr 876 25 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 876 26 . . . cord-028721-x6f26ahr 877 1 The the DT cord-028721-x6f26ahr 877 2 principal principal JJ cord-028721-x6f26ahr 877 3 secondary secondary JJ cord-028721-x6f26ahr 877 4 anomalies anomaly NNS cord-028721-x6f26ahr 877 5 include include VBP cord-028721-x6f26ahr 877 6 adrenal adrenal JJ cord-028721-x6f26ahr 877 7 cortical cortical JJ cord-028721-x6f26ahr 877 8 anomaly anomaly NN cord-028721-x6f26ahr 877 9 ( ( -LRB- cord-028721-x6f26ahr 877 10 congenital congenital JJ cord-028721-x6f26ahr 877 11 adrenal adrenal JJ cord-028721-x6f26ahr 877 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 877 13 , , , cord-028721-x6f26ahr 877 14 virilizing virilize VBG cord-028721-x6f26ahr 877 15 tumor tumor NN cord-028721-x6f26ahr 877 16 of of IN cord-028721-x6f26ahr 877 17 the the DT cord-028721-x6f26ahr 877 18 adrenal adrenal NN cord-028721-x6f26ahr 877 19 , , , cord-028721-x6f26ahr 877 20 and and CC cord-028721-x6f26ahr 877 21 Nelson Nelson NNP cord-028721-x6f26ahr 877 22 's 's POS cord-028721-x6f26ahr 877 23 syndrome syndrome NN cord-028721-x6f26ahr 877 24 ) ) -RRB- cord-028721-x6f26ahr 877 25 , , , cord-028721-x6f26ahr 877 26 and and CC cord-028721-x6f26ahr 877 27 lesion lesion NN cord-028721-x6f26ahr 877 28 secondary secondary JJ cord-028721-x6f26ahr 877 29 to to IN cord-028721-x6f26ahr 877 30 hCG hcg NN cord-028721-x6f26ahr 877 31 - - HYPH cord-028721-x6f26ahr 877 32 secreting secrete VBG cord-028721-x6f26ahr 877 33 tumor tumor NN cord-028721-x6f26ahr 877 34 ( ( -LRB- cord-028721-x6f26ahr 877 35 hepatoblastoma hepatoblastoma NNP cord-028721-x6f26ahr 877 36 accounts account VBZ cord-028721-x6f26ahr 877 37 for for IN cord-028721-x6f26ahr 877 38 half half NN cord-028721-x6f26ahr 877 39 of of IN cord-028721-x6f26ahr 877 40 precocious precocious JJ cord-028721-x6f26ahr 877 41 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 877 42 cases case NNS cord-028721-x6f26ahr 877 43 , , , cord-028721-x6f26ahr 877 44 and and CC cord-028721-x6f26ahr 877 45 testicular testicular JJ cord-028721-x6f26ahr 877 46 germ germ NN cord-028721-x6f26ahr 877 47 cell cell NN cord-028721-x6f26ahr 877 48 tumor tumor NN cord-028721-x6f26ahr 877 49 and and CC cord-028721-x6f26ahr 877 50 the the DT cord-028721-x6f26ahr 877 51 tumors tumor NNS cord-028721-x6f26ahr 877 52 of of IN cord-028721-x6f26ahr 877 53 the the DT cord-028721-x6f26ahr 877 54 retroperitoneum retroperitoneum NN cord-028721-x6f26ahr 877 55 , , , cord-028721-x6f26ahr 877 56 mediastinum mediastinum FW cord-028721-x6f26ahr 877 57 , , , cord-028721-x6f26ahr 877 58 and and CC cord-028721-x6f26ahr 877 59 pineal pineal NN cord-028721-x6f26ahr 877 60 gland gland NN cord-028721-x6f26ahr 877 61 are be VBP cord-028721-x6f26ahr 877 62 responsible responsible JJ cord-028721-x6f26ahr 877 63 for for IN cord-028721-x6f26ahr 877 64 the the DT cord-028721-x6f26ahr 877 65 other other JJ cord-028721-x6f26ahr 877 66 half half NN cord-028721-x6f26ahr 877 67 of of IN cord-028721-x6f26ahr 877 68 cases case NNS cord-028721-x6f26ahr 877 69 ) ) -RRB- cord-028721-x6f26ahr 877 70 . . . cord-028721-x6f26ahr 878 1 387 387 CD cord-028721-x6f26ahr 878 2 Familial familial JJ cord-028721-x6f26ahr 878 3 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 878 4 : : : cord-028721-x6f26ahr 878 5 gonadotropin gonadotropin NN cord-028721-x6f26ahr 878 6 - - HYPH cord-028721-x6f26ahr 878 7 independent independent JJ cord-028721-x6f26ahr 878 8 precocious precocious JJ cord-028721-x6f26ahr 878 9 puberty puberty NN cord-028721-x6f26ahr 878 10 ( ( -LRB- cord-028721-x6f26ahr 878 11 GIPP GIPP NNP cord-028721-x6f26ahr 878 12 ) ) -RRB- cord-028721-x6f26ahr 878 13 or or CC cord-028721-x6f26ahr 878 14 familial familial JJ cord-028721-x6f26ahr 878 15 male male NN cord-028721-x6f26ahr 878 16 - - HYPH cord-028721-x6f26ahr 878 17 limited limit VBN cord-028721-x6f26ahr 878 18 precocious precocious JJ cord-028721-x6f26ahr 878 19 puberty puberty NN cord-028721-x6f26ahr 878 20 ( ( -LRB- cord-028721-x6f26ahr 878 21 FMPP FMPP NNP cord-028721-x6f26ahr 878 22 ) ) -RRB- cord-028721-x6f26ahr 879 1 Familial familial JJ cord-028721-x6f26ahr 879 2 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 879 3 is be VBZ cord-028721-x6f26ahr 879 4 a a DT cord-028721-x6f26ahr 879 5 form form NN cord-028721-x6f26ahr 879 6 of of IN cord-028721-x6f26ahr 879 7 male male JJ cord-028721-x6f26ahr 879 8 sexual sexual JJ cord-028721-x6f26ahr 879 9 precocity precocity NN cord-028721-x6f26ahr 879 10 characterized characterize VBN cord-028721-x6f26ahr 879 11 by by IN cord-028721-x6f26ahr 879 12 early early JJ cord-028721-x6f26ahr 879 13 differentiation differentiation NN cord-028721-x6f26ahr 879 14 of of IN cord-028721-x6f26ahr 879 15 Leydig Leydig NNP cord-028721-x6f26ahr 879 16 cells cell NNS cord-028721-x6f26ahr 879 17 and and CC cord-028721-x6f26ahr 879 18 the the DT cord-028721-x6f26ahr 879 19 initiation initiation NN cord-028721-x6f26ahr 879 20 of of IN cord-028721-x6f26ahr 879 21 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 879 22 in in IN cord-028721-x6f26ahr 879 23 the the DT cord-028721-x6f26ahr 879 24 absence absence NN cord-028721-x6f26ahr 879 25 of of IN cord-028721-x6f26ahr 879 26 stimulation stimulation NN cord-028721-x6f26ahr 879 27 by by IN cord-028721-x6f26ahr 879 28 pituitary pituitary JJ cord-028721-x6f26ahr 879 29 gonadotropin gonadotropin NN cord-028721-x6f26ahr 879 30 . . . cord-028721-x6f26ahr 880 1 This this DT cord-028721-x6f26ahr 880 2 is be VBZ cord-028721-x6f26ahr 880 3 a a DT cord-028721-x6f26ahr 880 4 primary primary JJ cord-028721-x6f26ahr 880 5 testicular testicular JJ cord-028721-x6f26ahr 880 6 abnormality abnormality NN cord-028721-x6f26ahr 880 7 with with IN cord-028721-x6f26ahr 880 8 autosomal autosomal JJ cord-028721-x6f26ahr 880 9 dominant dominant JJ cord-028721-x6f26ahr 880 10 inheritance inheritance NN cord-028721-x6f26ahr 880 11 . . . cord-028721-x6f26ahr 881 1 388 388 CD cord-028721-x6f26ahr 881 2 , , , cord-028721-x6f26ahr 881 3 389 389 CD cord-028721-x6f26ahr 881 4 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 881 5 studies study NNS cord-028721-x6f26ahr 882 1 confi confi NNP cord-028721-x6f26ahr 882 2 rm rm NNP cord-028721-x6f26ahr 883 1 an an DT cord-028721-x6f26ahr 883 2 adult adult NN cord-028721-x6f26ahr 883 3 Leydig Leydig NNP cord-028721-x6f26ahr 883 4 cell cell NN cord-028721-x6f26ahr 883 5 pattern pattern NN cord-028721-x6f26ahr 883 6 and and CC cord-028721-x6f26ahr 883 7 complete complete JJ cord-028721-x6f26ahr 883 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 883 9 , , , cord-028721-x6f26ahr 883 10 although although IN cord-028721-x6f26ahr 883 11 many many JJ cord-028721-x6f26ahr 883 12 spermatids spermatid NNS cord-028721-x6f26ahr 883 13 are be VBP cord-028721-x6f26ahr 883 14 abnormal abnormal JJ cord-028721-x6f26ahr 883 15 . . . cord-028721-x6f26ahr 884 1 390 390 CD cord-028721-x6f26ahr 885 1 The the DT cord-028721-x6f26ahr 885 2 cause cause NN cord-028721-x6f26ahr 885 3 of of IN cord-028721-x6f26ahr 885 4 familial familial JJ cord-028721-x6f26ahr 885 5 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 885 6 is be VBZ cord-028721-x6f26ahr 885 7 a a DT cord-028721-x6f26ahr 885 8 constitutive constitutive JJ cord-028721-x6f26ahr 885 9 activating activate VBG cord-028721-x6f26ahr 885 10 mutation mutation NN cord-028721-x6f26ahr 885 11 of of IN cord-028721-x6f26ahr 885 12 the the DT cord-028721-x6f26ahr 885 13 LH LH NNP cord-028721-x6f26ahr 885 14 receptor receptor NN cord-028721-x6f26ahr 885 15 gene gene NN cord-028721-x6f26ahr 885 16 . . . cord-028721-x6f26ahr 886 1 391 391 CD cord-028721-x6f26ahr 887 1 This this DT cord-028721-x6f26ahr 887 2 gene gene NN cord-028721-x6f26ahr 887 3 comprises comprise VBZ cord-028721-x6f26ahr 887 4 11 11 CD cord-028721-x6f26ahr 887 5 exons exon NNS cord-028721-x6f26ahr 887 6 and and CC cord-028721-x6f26ahr 887 7 has have VBZ cord-028721-x6f26ahr 887 8 been be VBN cord-028721-x6f26ahr 887 9 mapped map VBN cord-028721-x6f26ahr 887 10 to to IN cord-028721-x6f26ahr 887 11 2p21 2p21 CD cord-028721-x6f26ahr 887 12 . . . cord-028721-x6f26ahr 888 1 Hormonal hormonal JJ cord-028721-x6f26ahr 888 2 measurements measurement NNS cord-028721-x6f26ahr 888 3 show show VBP cord-028721-x6f26ahr 888 4 elevated elevated JJ cord-028721-x6f26ahr 888 5 serum serum NN cord-028721-x6f26ahr 888 6 levels level NNS cord-028721-x6f26ahr 888 7 of of IN cord-028721-x6f26ahr 888 8 testosterone testosterone NN cord-028721-x6f26ahr 888 9 , , , cord-028721-x6f26ahr 888 10 and and CC cord-028721-x6f26ahr 888 11 low low JJ cord-028721-x6f26ahr 888 12 levels level NNS cord-028721-x6f26ahr 888 13 of of IN cord-028721-x6f26ahr 888 14 dihydroepiandrosterone dihydroepiandrosterone NN cord-028721-x6f26ahr 888 15 sulfate sulfate NN cord-028721-x6f26ahr 888 16 , , , cord-028721-x6f26ahr 888 17 androstenedione androstenedione NN cord-028721-x6f26ahr 888 18 , , , cord-028721-x6f26ahr 888 19 17-hydroxyprogesterone 17-hydroxyprogesterone CD cord-028721-x6f26ahr 888 20 , , , cord-028721-x6f26ahr 888 21 gonadotropin gonadotropin NN cord-028721-x6f26ahr 888 22 - - HYPH cord-028721-x6f26ahr 888 23 releasing release VBG cord-028721-x6f26ahr 888 24 hormone hormone NN cord-028721-x6f26ahr 888 25 ( ( -LRB- cord-028721-x6f26ahr 888 26 GRH GRH NNP cord-028721-x6f26ahr 888 27 ) ) -RRB- cord-028721-x6f26ahr 888 28 , , , cord-028721-x6f26ahr 888 29 and and CC cord-028721-x6f26ahr 888 30 LH LH NNP cord-028721-x6f26ahr 888 31 , , , cord-028721-x6f26ahr 888 32 as as RB cord-028721-x6f26ahr 888 33 well well RB cord-028721-x6f26ahr 888 34 as as IN cord-028721-x6f26ahr 888 35 absence absence NN cord-028721-x6f26ahr 888 36 of of IN cord-028721-x6f26ahr 888 37 a a DT cord-028721-x6f26ahr 888 38 pulsatile pulsatile JJ cord-028721-x6f26ahr 888 39 pattern pattern NN cord-028721-x6f26ahr 888 40 . . . cord-028721-x6f26ahr 889 1 In in IN cord-028721-x6f26ahr 889 2 addition addition NN cord-028721-x6f26ahr 889 3 , , , cord-028721-x6f26ahr 889 4 serum serum NN cord-028721-x6f26ahr 889 5 levels level NNS cord-028721-x6f26ahr 889 6 of of IN cord-028721-x6f26ahr 889 7 inhibin inhibin NNP cord-028721-x6f26ahr 889 8 B B NNP cord-028721-x6f26ahr 889 9 appear appear VB cord-028721-x6f26ahr 889 10 elevated elevate VBN cord-028721-x6f26ahr 889 11 before before IN cord-028721-x6f26ahr 889 12 the the DT cord-028721-x6f26ahr 889 13 normal normal JJ cord-028721-x6f26ahr 889 14 age age NN cord-028721-x6f26ahr 889 15 of of IN cord-028721-x6f26ahr 889 16 onset onset NN cord-028721-x6f26ahr 889 17 of of IN cord-028721-x6f26ahr 889 18 puberty puberty NN cord-028721-x6f26ahr 889 19 . . . cord-028721-x6f26ahr 890 1 392 392 CD cord-028721-x6f26ahr 891 1 In in IN cord-028721-x6f26ahr 891 2 some some DT cord-028721-x6f26ahr 891 3 patients patient NNS cord-028721-x6f26ahr 891 4 , , , cord-028721-x6f26ahr 891 5 a a DT cord-028721-x6f26ahr 891 6 mutation mutation NN cord-028721-x6f26ahr 891 7 in in IN cord-028721-x6f26ahr 891 8 LH LH NNP cord-028721-x6f26ahr 891 9 receptor receptor NN cord-028721-x6f26ahr 891 10 induces induce VBZ cord-028721-x6f26ahr 891 11 Leydig Leydig NNP cord-028721-x6f26ahr 891 12 cell cell NN cord-028721-x6f26ahr 891 13 adenoma adenoma NN cord-028721-x6f26ahr 891 14 . . . cord-028721-x6f26ahr 892 1 393 393 CD cord-028721-x6f26ahr 892 2 Precocious precocious JJ cord-028721-x6f26ahr 892 3 puberty puberty NN cord-028721-x6f26ahr 892 4 secondary secondary JJ cord-028721-x6f26ahr 892 5 to to IN cord-028721-x6f26ahr 892 6 functioning function VBG cord-028721-x6f26ahr 892 7 testicular testicular JJ cord-028721-x6f26ahr 892 8 tumor tumor NN cord-028721-x6f26ahr 893 1 A a DT cord-028721-x6f26ahr 893 2 syndrome syndrome NN cord-028721-x6f26ahr 893 3 of of IN cord-028721-x6f26ahr 893 4 precocious precocious JJ cord-028721-x6f26ahr 893 5 puberty puberty NN cord-028721-x6f26ahr 893 6 can can MD cord-028721-x6f26ahr 893 7 be be VB cord-028721-x6f26ahr 893 8 the the DT cord-028721-x6f26ahr 893 9 result result NN cord-028721-x6f26ahr 893 10 of of IN cord-028721-x6f26ahr 893 11 different different JJ cord-028721-x6f26ahr 893 12 tumors tumor NNS cord-028721-x6f26ahr 893 13 , , , cord-028721-x6f26ahr 893 14 including include VBG cord-028721-x6f26ahr 893 15 Leydig leydig NN cord-028721-x6f26ahr 893 16 cell cell NN cord-028721-x6f26ahr 893 17 tumor tumor NN cord-028721-x6f26ahr 893 18 , , , cord-028721-x6f26ahr 893 19 sex sex NN cord-028721-x6f26ahr 893 20 cord cord NN cord-028721-x6f26ahr 893 21 tumor tumor NN cord-028721-x6f26ahr 893 22 , , , cord-028721-x6f26ahr 893 23 adrenal adrenal JJ cord-028721-x6f26ahr 893 24 cortex cortex NN cord-028721-x6f26ahr 893 25 virilizing virilizing NN cord-028721-x6f26ahr 893 26 carcinoma carcinoma NN cord-028721-x6f26ahr 893 27 , , , cord-028721-x6f26ahr 893 28 and and CC cord-028721-x6f26ahr 893 29 extratesticular extratesticular JJ cord-028721-x6f26ahr 893 30 hCG hcg NN cord-028721-x6f26ahr 893 31 - - HYPH cord-028721-x6f26ahr 893 32 secreting secrete VBG cord-028721-x6f26ahr 893 33 germ germ NN cord-028721-x6f26ahr 893 34 cell cell NN cord-028721-x6f26ahr 893 35 tumor tumor NN cord-028721-x6f26ahr 893 36 . . . cord-028721-x6f26ahr 894 1 Leydig leydig NN cord-028721-x6f26ahr 894 2 cell cell NN cord-028721-x6f26ahr 894 3 tumor tumor NN cord-028721-x6f26ahr 894 4 may may MD cord-028721-x6f26ahr 894 5 cause cause VB cord-028721-x6f26ahr 894 6 precocious precocious JJ cord-028721-x6f26ahr 894 7 puberty puberty NN cord-028721-x6f26ahr 894 8 . . . cord-028721-x6f26ahr 895 1 The the DT cord-028721-x6f26ahr 895 2 testis testis NN cord-028721-x6f26ahr 895 3 is be VBZ cord-028721-x6f26ahr 895 4 enlarged enlarge VBN cord-028721-x6f26ahr 895 5 owing owe VBG cord-028721-x6f26ahr 895 6 to to IN cord-028721-x6f26ahr 895 7 tumor tumor NN cord-028721-x6f26ahr 895 8 growth growth NN cord-028721-x6f26ahr 895 9 and and CC cord-028721-x6f26ahr 895 10 maturation maturation NN cord-028721-x6f26ahr 895 11 of of IN cord-028721-x6f26ahr 895 12 the the DT cord-028721-x6f26ahr 895 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 895 14 tubules tubule NNS cord-028721-x6f26ahr 895 15 adjacent adjacent JJ cord-028721-x6f26ahr 895 16 to to IN cord-028721-x6f26ahr 895 17 the the DT cord-028721-x6f26ahr 895 18 tumor tumor NN cord-028721-x6f26ahr 895 19 ; ; : cord-028721-x6f26ahr 895 20 such such JJ cord-028721-x6f26ahr 895 21 maturation maturation NN cord-028721-x6f26ahr 895 22 results result NNS cord-028721-x6f26ahr 895 23 from from IN cord-028721-x6f26ahr 895 24 androgen androgen NN cord-028721-x6f26ahr 895 25 secretion secretion NN cord-028721-x6f26ahr 895 26 by by IN cord-028721-x6f26ahr 895 27 tumor tumor NN cord-028721-x6f26ahr 895 28 cells cell NNS cord-028721-x6f26ahr 895 29 ( ( -LRB- cord-028721-x6f26ahr 895 30 Fig Fig NNP cord-028721-x6f26ahr 895 31 . . . cord-028721-x6f26ahr 895 32 12 12 CD cord-028721-x6f26ahr 895 33 - - SYM cord-028721-x6f26ahr 895 34 35 35 CD cord-028721-x6f26ahr 895 35 ) ) -RRB- cord-028721-x6f26ahr 895 36 . . . cord-028721-x6f26ahr 896 1 In in IN cord-028721-x6f26ahr 896 2 most most JJS cord-028721-x6f26ahr 896 3 cases case NNS cord-028721-x6f26ahr 896 4 , , , cord-028721-x6f26ahr 896 5 the the DT cord-028721-x6f26ahr 896 6 contralateral contralateral JJ cord-028721-x6f26ahr 896 7 testis testis NN cord-028721-x6f26ahr 896 8 is be VBZ cord-028721-x6f26ahr 896 9 not not RB cord-028721-x6f26ahr 896 10 enlarged enlarge VBN cord-028721-x6f26ahr 896 11 . . . cord-028721-x6f26ahr 897 1 394 394 CD cord-028721-x6f26ahr 897 2 , , , cord-028721-x6f26ahr 897 3 395 395 CD cord-028721-x6f26ahr 897 4 Sex sex NN cord-028721-x6f26ahr 897 5 cord cord NN cord-028721-x6f26ahr 897 6 tumor tumor NN cord-028721-x6f26ahr 897 7 with with IN cord-028721-x6f26ahr 897 8 annular annular JJ cord-028721-x6f26ahr 897 9 tubules tubule NNS cord-028721-x6f26ahr 897 10 and and CC cord-028721-x6f26ahr 897 11 large large JJ cord-028721-x6f26ahr 897 12 cell cell NN cord-028721-x6f26ahr 898 1 calcifying calcify VBG cord-028721-x6f26ahr 898 2 Sertoli sertoli JJ cord-028721-x6f26ahr 898 3 cell cell NN cord-028721-x6f26ahr 898 4 tumor tumor NN cord-028721-x6f26ahr 898 5 may may MD cord-028721-x6f26ahr 898 6 give give VB cord-028721-x6f26ahr 898 7 rise rise NN cord-028721-x6f26ahr 898 8 to to IN cord-028721-x6f26ahr 898 9 precocious precocious JJ cord-028721-x6f26ahr 898 10 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 898 11 that that WDT cord-028721-x6f26ahr 898 12 is be VBZ cord-028721-x6f26ahr 898 13 isosexual isosexual JJ cord-028721-x6f26ahr 898 14 ( ( -LRB- cord-028721-x6f26ahr 898 15 development development NN cord-028721-x6f26ahr 898 16 of of IN cord-028721-x6f26ahr 898 17 musculature musculature NN cord-028721-x6f26ahr 898 18 and and CC cord-028721-x6f26ahr 898 19 axillary axillary JJ cord-028721-x6f26ahr 898 20 and and CC cord-028721-x6f26ahr 898 21 pubic pubic JJ cord-028721-x6f26ahr 898 22 hair hair NN cord-028721-x6f26ahr 898 23 ) ) -RRB- cord-028721-x6f26ahr 898 24 and and CC cord-028721-x6f26ahr 898 25 heterosexual heterosexual JJ cord-028721-x6f26ahr 898 26 ( ( -LRB- cord-028721-x6f26ahr 898 27 gynecomastia gynecomastia NN cord-028721-x6f26ahr 898 28 ) ) -RRB- cord-028721-x6f26ahr 898 29 . . . cord-028721-x6f26ahr 899 1 This this DT cord-028721-x6f26ahr 899 2 precocious precocious JJ cord-028721-x6f26ahr 899 3 testicular testicular JJ cord-028721-x6f26ahr 899 4 maturation maturation NN cord-028721-x6f26ahr 899 5 and and CC cord-028721-x6f26ahr 899 6 the the DT cord-028721-x6f26ahr 899 7 development development NN cord-028721-x6f26ahr 899 8 of of IN cord-028721-x6f26ahr 899 9 the the DT cord-028721-x6f26ahr 899 10 tumor tumor NN cord-028721-x6f26ahr 899 11 itself -PRON- PRP cord-028721-x6f26ahr 899 12 cause cause VBP cord-028721-x6f26ahr 899 13 testicular testicular JJ cord-028721-x6f26ahr 899 14 enlargement enlargement NN cord-028721-x6f26ahr 899 15 . . . cord-028721-x6f26ahr 900 1 It -PRON- PRP cord-028721-x6f26ahr 900 2 has have VBZ cord-028721-x6f26ahr 900 3 been be VBN cord-028721-x6f26ahr 900 4 suggested suggest VBN cord-028721-x6f26ahr 900 5 that that IN cord-028721-x6f26ahr 900 6 tumor tumor NN cord-028721-x6f26ahr 900 7 cells cell NNS cord-028721-x6f26ahr 900 8 stimulate stimulate VBP cord-028721-x6f26ahr 900 9 Leydig leydig NN cord-028721-x6f26ahr 900 10 cells cell NNS cord-028721-x6f26ahr 900 11 to to TO cord-028721-x6f26ahr 900 12 produce produce VB cord-028721-x6f26ahr 900 13 androgens androgen NNS cord-028721-x6f26ahr 900 14 that that WDT cord-028721-x6f26ahr 900 15 are be VBP cord-028721-x6f26ahr 900 16 aromatized aromatize VBN cord-028721-x6f26ahr 900 17 to to IN cord-028721-x6f26ahr 900 18 estrogens estrogen NNS cord-028721-x6f26ahr 900 19 by by IN cord-028721-x6f26ahr 900 20 the the DT cord-028721-x6f26ahr 900 21 tumor tumor NN cord-028721-x6f26ahr 900 22 cells cell NNS cord-028721-x6f26ahr 900 23 themselves -PRON- PRP cord-028721-x6f26ahr 900 24 , , , cord-028721-x6f26ahr 900 25 thus thus RB cord-028721-x6f26ahr 900 26 accounting account VBG cord-028721-x6f26ahr 900 27 for for IN cord-028721-x6f26ahr 900 28 the the DT cord-028721-x6f26ahr 900 29 clinical clinical JJ cord-028721-x6f26ahr 900 30 symptoms symptom NNS cord-028721-x6f26ahr 900 31 . . . cord-028721-x6f26ahr 901 1 These these DT cord-028721-x6f26ahr 901 2 tumors tumor NNS cord-028721-x6f26ahr 901 3 are be VBP cord-028721-x6f26ahr 901 4 frequently frequently RB cord-028721-x6f26ahr 901 5 observed observe VBN cord-028721-x6f26ahr 901 6 in in IN cord-028721-x6f26ahr 901 7 Peutz Peutz NNP cord-028721-x6f26ahr 901 8 - - HYPH cord-028721-x6f26ahr 901 9 Jeghers Jeghers NNP cord-028721-x6f26ahr 901 10 syndrome syndrome NN cord-028721-x6f26ahr 901 11 396,397 396,397 CD cord-028721-x6f26ahr 901 12 and and CC cord-028721-x6f26ahr 901 13 Carney Carney NNP cord-028721-x6f26ahr 901 14 's 's POS cord-028721-x6f26ahr 901 15 complex complex NN cord-028721-x6f26ahr 901 16 . . . cord-028721-x6f26ahr 902 1 398 398 CD cord-028721-x6f26ahr 902 2 Most Most JJS cord-028721-x6f26ahr 902 3 infants infant NNS cord-028721-x6f26ahr 902 4 with with IN cord-028721-x6f26ahr 902 5 adrenal adrenal JJ cord-028721-x6f26ahr 902 6 cortex cortex NN cord-028721-x6f26ahr 902 7 virilizing virilizing NN cord-028721-x6f26ahr 902 8 tumors tumor NNS cord-028721-x6f26ahr 902 9 have have VBP cord-028721-x6f26ahr 902 10 small small JJ cord-028721-x6f26ahr 902 11 testes testis NNS cord-028721-x6f26ahr 902 12 , , , cord-028721-x6f26ahr 902 13 but but CC cord-028721-x6f26ahr 902 14 some some DT cord-028721-x6f26ahr 902 15 cases case NNS cord-028721-x6f26ahr 902 16 of of IN cord-028721-x6f26ahr 902 17 testicular testicular JJ cord-028721-x6f26ahr 902 18 hypertrophy hypertrophy NN cord-028721-x6f26ahr 902 19 have have VBP cord-028721-x6f26ahr 902 20 also also RB cord-028721-x6f26ahr 902 21 been be VBN cord-028721-x6f26ahr 902 22 observed observe VBN cord-028721-x6f26ahr 902 23 . . . cord-028721-x6f26ahr 903 1 399 399 CD cord-028721-x6f26ahr 903 2 Testicular Testicular NNP cord-028721-x6f26ahr 903 3 development development NN cord-028721-x6f26ahr 903 4 in in IN cord-028721-x6f26ahr 903 5 these these DT cord-028721-x6f26ahr 903 6 cases case NNS cord-028721-x6f26ahr 903 7 is be VBZ cord-028721-x6f26ahr 903 8 attributed attribute VBN cord-028721-x6f26ahr 903 9 to to IN cord-028721-x6f26ahr 903 10 adrenal adrenal JJ cord-028721-x6f26ahr 903 11 androgenic androgenic JJ cord-028721-x6f26ahr 903 12 action action NN cord-028721-x6f26ahr 903 13 on on IN cord-028721-x6f26ahr 903 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 903 15 tubules tubule NNS cord-028721-x6f26ahr 903 16 . . . cord-028721-x6f26ahr 904 1 400 400 CD cord-028721-x6f26ahr 905 1 In in IN cord-028721-x6f26ahr 905 2 untreated untreated JJ cord-028721-x6f26ahr 905 3 ( ( -LRB- cord-028721-x6f26ahr 905 4 or or CC cord-028721-x6f26ahr 905 5 maltreated maltreated JJ cord-028721-x6f26ahr 905 6 ) ) -RRB- cord-028721-x6f26ahr 905 7 congenital congenital JJ cord-028721-x6f26ahr 905 8 adrenal adrenal JJ cord-028721-x6f26ahr 905 9 hyperplasia hyperplasia NN cord-028721-x6f26ahr 905 10 , , , cord-028721-x6f26ahr 905 11 both both DT cord-028721-x6f26ahr 905 12 testes testis NNS cord-028721-x6f26ahr 905 13 can can MD cord-028721-x6f26ahr 905 14 be be VB cord-028721-x6f26ahr 905 15 enlarged enlarge VBN cord-028721-x6f26ahr 905 16 because because IN cord-028721-x6f26ahr 905 17 they -PRON- PRP cord-028721-x6f26ahr 905 18 contain contain VBP cord-028721-x6f26ahr 905 19 growing grow VBG cord-028721-x6f26ahr 905 20 masses masse NNS cord-028721-x6f26ahr 905 21 of of IN cord-028721-x6f26ahr 905 22 adrenal adrenal JJ cord-028721-x6f26ahr 905 23 cortex cortex NN cord-028721-x6f26ahr 905 24 - - HYPH cord-028721-x6f26ahr 905 25 like like JJ cord-028721-x6f26ahr 905 26 cells cell NNS cord-028721-x6f26ahr 905 27 . . . cord-028721-x6f26ahr 906 1 401 401 CD cord-028721-x6f26ahr 907 1 A a DT cord-028721-x6f26ahr 907 2 similar similar JJ cord-028721-x6f26ahr 907 3 condition condition NN cord-028721-x6f26ahr 907 4 is be VBZ cord-028721-x6f26ahr 907 5 observed observe VBN cord-028721-x6f26ahr 907 6 in in IN cord-028721-x6f26ahr 907 7 Nelson Nelson NNP cord-028721-x6f26ahr 907 8 's 's POS cord-028721-x6f26ahr 907 9 syndrome syndrome NN cord-028721-x6f26ahr 907 10 . . . cord-028721-x6f26ahr 908 1 Testicular testicular JJ cord-028721-x6f26ahr 908 2 enlargement enlargement NN cord-028721-x6f26ahr 908 3 is be VBZ cord-028721-x6f26ahr 908 4 modest modest JJ cord-028721-x6f26ahr 908 5 in in IN cord-028721-x6f26ahr 908 6 paraneoplastic paraneoplastic JJ cord-028721-x6f26ahr 908 7 precocious precocious JJ cord-028721-x6f26ahr 908 8 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 908 9 secondary secondary JJ cord-028721-x6f26ahr 908 10 to to IN cord-028721-x6f26ahr 908 11 hepatoblastoma hepatoblastoma NNP cord-028721-x6f26ahr 908 12 402 402 CD cord-028721-x6f26ahr 908 13 or or CC cord-028721-x6f26ahr 908 14 extratesticular extratesticular JJ cord-028721-x6f26ahr 908 15 hCG hcg NN cord-028721-x6f26ahr 908 16 - - HYPH cord-028721-x6f26ahr 908 17 secreting secrete VBG cord-028721-x6f26ahr 908 18 germ germ NN cord-028721-x6f26ahr 908 19 cell cell NN cord-028721-x6f26ahr 908 20 tumor tumor NN cord-028721-x6f26ahr 908 21 , , , cord-028721-x6f26ahr 908 22 although although IN cord-028721-x6f26ahr 908 23 nodular nodular JJ cord-028721-x6f26ahr 908 24 or or CC cord-028721-x6f26ahr 908 25 diffuse diffuse VB cord-028721-x6f26ahr 908 26 precocious precocious JJ cord-028721-x6f26ahr 908 27 maturation maturation NN cord-028721-x6f26ahr 908 28 has have VBZ cord-028721-x6f26ahr 908 29 been be VBN cord-028721-x6f26ahr 908 30 occasionally occasionally RB cord-028721-x6f26ahr 908 31 reported report VBN cord-028721-x6f26ahr 908 32 . . . cord-028721-x6f26ahr 909 1 403 403 CD cord-028721-x6f26ahr 910 1 Precocious precocious JJ cord-028721-x6f26ahr 910 2 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 910 3 secondary secondary JJ cord-028721-x6f26ahr 910 4 to to IN cord-028721-x6f26ahr 910 5 excessive excessive JJ cord-028721-x6f26ahr 910 6 aromatase aromatase NN cord-028721-x6f26ahr 910 7 activity activity NN cord-028721-x6f26ahr 911 1 Biosynthesis Biosynthesis NNP cord-028721-x6f26ahr 911 2 of of IN cord-028721-x6f26ahr 911 3 C18 C18 NNP cord-028721-x6f26ahr 911 4 estrogens estrogen NNS cord-028721-x6f26ahr 911 5 from from IN cord-028721-x6f26ahr 911 6 C19 C19 NNP cord-028721-x6f26ahr 911 7 androgens androgen NNS cord-028721-x6f26ahr 911 8 occurs occur VBZ cord-028721-x6f26ahr 911 9 by by IN cord-028721-x6f26ahr 911 10 three three CD cord-028721-x6f26ahr 911 11 consecutive consecutive JJ cord-028721-x6f26ahr 911 12 oxidative oxidative JJ cord-028721-x6f26ahr 911 13 reactions reaction NNS cord-028721-x6f26ahr 911 14 that that WDT cord-028721-x6f26ahr 911 15 are be VBP cord-028721-x6f26ahr 911 16 catalyzed catalyze VBN cord-028721-x6f26ahr 911 17 by by IN cord-028721-x6f26ahr 911 18 an an DT cord-028721-x6f26ahr 911 19 enzymatic enzymatic JJ cord-028721-x6f26ahr 911 20 complex complex NN cord-028721-x6f26ahr 911 21 known know VBN cord-028721-x6f26ahr 911 22 as as IN cord-028721-x6f26ahr 911 23 estrogen estrogen NN cord-028721-x6f26ahr 911 24 synthetase synthetase NN cord-028721-x6f26ahr 911 25 or or CC cord-028721-x6f26ahr 911 26 aromatase aromatase NN cord-028721-x6f26ahr 911 27 . . . cord-028721-x6f26ahr 912 1 404 404 CD cord-028721-x6f26ahr 913 1 This this DT cord-028721-x6f26ahr 913 2 complex complex NN cord-028721-x6f26ahr 913 3 has have VBZ cord-028721-x6f26ahr 913 4 two two CD cord-028721-x6f26ahr 913 5 components component NNS cord-028721-x6f26ahr 913 6 : : : cord-028721-x6f26ahr 913 7 P450 p450 JJ cord-028721-x6f26ahr 913 8 arom arom NN cord-028721-x6f26ahr 913 9 ( ( -LRB- cord-028721-x6f26ahr 913 10 a a DT cord-028721-x6f26ahr 913 11 product product NN cord-028721-x6f26ahr 913 12 from from IN cord-028721-x6f26ahr 913 13 the the DT cord-028721-x6f26ahr 913 14 CYP19 cyp19 NN cord-028721-x6f26ahr 913 15 gene gene NN cord-028721-x6f26ahr 913 16 located locate VBN cord-028721-x6f26ahr 913 17 on on IN cord-028721-x6f26ahr 913 18 15p21.1 15p21.1 CD cord-028721-x6f26ahr 913 19 ) ) -RRB- cord-028721-x6f26ahr 913 20 , , , cord-028721-x6f26ahr 913 21 405 405 CD cord-028721-x6f26ahr 913 22 which which WDT cord-028721-x6f26ahr 913 23 joins join VBZ cord-028721-x6f26ahr 913 24 C19 C19 NNP cord-028721-x6f26ahr 913 25 substrate substrate NN cord-028721-x6f26ahr 913 26 and and CC cord-028721-x6f26ahr 913 27 catalyzes catalyze VBZ cord-028721-x6f26ahr 913 28 the the DT cord-028721-x6f26ahr 913 29 insertion insertion NN cord-028721-x6f26ahr 913 30 of of IN cord-028721-x6f26ahr 913 31 oxygen oxygen NN cord-028721-x6f26ahr 913 32 in in IN cord-028721-x6f26ahr 913 33 C19 C19 NNP cord-028721-x6f26ahr 913 34 to to TO cord-028721-x6f26ahr 913 35 form form VB cord-028721-x6f26ahr 913 36 C18 C18 NNP cord-028721-x6f26ahr 913 37 estrogens estrogen NNS cord-028721-x6f26ahr 913 38 ; ; : cord-028721-x6f26ahr 913 39 and and CC cord-028721-x6f26ahr 913 40 NADPH nadph NN cord-028721-x6f26ahr 913 41 - - HYPH cord-028721-x6f26ahr 913 42 cytochrome cytochrome JJ cord-028721-x6f26ahr 913 43 P450 p450 JJ cord-028721-x6f26ahr 913 44 reductase reductase NN cord-028721-x6f26ahr 913 45 , , , cord-028721-x6f26ahr 913 46 a a DT cord-028721-x6f26ahr 913 47 ubiquitous ubiquitous JJ cord-028721-x6f26ahr 913 48 fl fl NNP cord-028721-x6f26ahr 913 49 avoprotein avoprotein NNP cord-028721-x6f26ahr 913 50 that that WDT cord-028721-x6f26ahr 913 51 conveys convey VBZ cord-028721-x6f26ahr 913 52 reducing reduce VBG cord-028721-x6f26ahr 913 53 equivalents equivalent NNS cord-028721-x6f26ahr 913 54 to to IN cord-028721-x6f26ahr 913 55 any any DT cord-028721-x6f26ahr 913 56 form form NN cord-028721-x6f26ahr 913 57 of of IN cord-028721-x6f26ahr 913 58 cytochrome cytochrome NN cord-028721-x6f26ahr 913 59 P450 p450 NN cord-028721-x6f26ahr 913 60 it -PRON- PRP cord-028721-x6f26ahr 913 61 meets meet VBZ cord-028721-x6f26ahr 913 62 . . . cord-028721-x6f26ahr 914 1 Aromatase aromatase NN cord-028721-x6f26ahr 914 2 is be VBZ cord-028721-x6f26ahr 914 3 in in IN cord-028721-x6f26ahr 914 4 the the DT cord-028721-x6f26ahr 914 5 endoplasmic endoplasmic NN cord-028721-x6f26ahr 914 6 reticulum reticulum NN cord-028721-x6f26ahr 914 7 of of IN cord-028721-x6f26ahr 914 8 estrogensynthesizing estrogensynthesize VBG cord-028721-x6f26ahr 914 9 cells cell NNS cord-028721-x6f26ahr 914 10 and and CC cord-028721-x6f26ahr 914 11 expressed express VBN cord-028721-x6f26ahr 914 12 in in IN cord-028721-x6f26ahr 914 13 placenta placenta NN cord-028721-x6f26ahr 914 14 , , , cord-028721-x6f26ahr 914 15 ovarian ovarian JJ cord-028721-x6f26ahr 914 16 granulosa granulosa NN cord-028721-x6f26ahr 914 17 , , , cord-028721-x6f26ahr 914 18 Sertoli sertoli JJ cord-028721-x6f26ahr 914 19 cells cell NNS cord-028721-x6f26ahr 914 20 , , , cord-028721-x6f26ahr 914 21 Leydig leydig NN cord-028721-x6f26ahr 914 22 cells cell NNS cord-028721-x6f26ahr 914 23 , , , cord-028721-x6f26ahr 914 24 adipose adipose JJ cord-028721-x6f26ahr 914 25 tissue tissue NN cord-028721-x6f26ahr 914 26 , , , cord-028721-x6f26ahr 914 27 and and CC cord-028721-x6f26ahr 914 28 several several JJ cord-028721-x6f26ahr 914 29 central central JJ cord-028721-x6f26ahr 914 30 nervous nervous JJ cord-028721-x6f26ahr 914 31 system system NN cord-028721-x6f26ahr 914 32 regions region NNS cord-028721-x6f26ahr 914 33 , , , cord-028721-x6f26ahr 914 34 including include VBG cord-028721-x6f26ahr 914 35 the the DT cord-028721-x6f26ahr 914 36 hypothalamus hypothalamus NN cord-028721-x6f26ahr 914 37 , , , cord-028721-x6f26ahr 914 38 amygdala amygdala NN cord-028721-x6f26ahr 914 39 , , , cord-028721-x6f26ahr 914 40 and and CC cord-028721-x6f26ahr 914 41 hippocampus hippocampus NN cord-028721-x6f26ahr 914 42 . . . cord-028721-x6f26ahr 915 1 Excessive excessive JJ cord-028721-x6f26ahr 915 2 aromatase aromatase NN cord-028721-x6f26ahr 915 3 causes cause VBZ cord-028721-x6f26ahr 915 4 excessive excessive JJ cord-028721-x6f26ahr 915 5 conversion conversion NN cord-028721-x6f26ahr 915 6 of of IN cord-028721-x6f26ahr 915 7 androgens androgen NNS cord-028721-x6f26ahr 915 8 to to IN cord-028721-x6f26ahr 915 9 estrogen estrogen NN cord-028721-x6f26ahr 915 10 , , , cord-028721-x6f26ahr 915 11 406 406 CD cord-028721-x6f26ahr 915 12 and and CC cord-028721-x6f26ahr 915 13 is be VBZ cord-028721-x6f26ahr 915 14 a a DT cord-028721-x6f26ahr 915 15 heterogeneous heterogeneous JJ cord-028721-x6f26ahr 915 16 genetic genetic JJ cord-028721-x6f26ahr 915 17 disorder disorder NN cord-028721-x6f26ahr 915 18 with with IN cord-028721-x6f26ahr 915 19 an an DT cord-028721-x6f26ahr 915 20 autosomal autosomal JJ cord-028721-x6f26ahr 915 21 dominant dominant JJ cord-028721-x6f26ahr 915 22 inheritance inheritance NN cord-028721-x6f26ahr 915 23 . . . cord-028721-x6f26ahr 916 1 The the DT cord-028721-x6f26ahr 916 2 disorder disorder NN cord-028721-x6f26ahr 916 3 leads lead VBZ cord-028721-x6f26ahr 916 4 to to IN cord-028721-x6f26ahr 916 5 heterosexual heterosexual JJ cord-028721-x6f26ahr 916 6 precocious precocious JJ cord-028721-x6f26ahr 916 7 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 916 8 with with IN cord-028721-x6f26ahr 916 9 gynecomastia gynecomastia NN cord-028721-x6f26ahr 916 10 in in IN cord-028721-x6f26ahr 916 11 males male NNS cord-028721-x6f26ahr 916 12 , , , cord-028721-x6f26ahr 916 13 and and CC cord-028721-x6f26ahr 916 14 to to IN cord-028721-x6f26ahr 916 15 isosexual isosexual JJ cord-028721-x6f26ahr 916 16 precocity precocity NN cord-028721-x6f26ahr 916 17 and and CC cord-028721-x6f26ahr 916 18 macromastia macromastia NN cord-028721-x6f26ahr 916 19 in in IN cord-028721-x6f26ahr 916 20 females female NNS cord-028721-x6f26ahr 916 21 . . . cord-028721-x6f26ahr 917 1 Ultimately ultimately RB cord-028721-x6f26ahr 917 2 , , , cord-028721-x6f26ahr 917 3 patient patient JJ cord-028721-x6f26ahr 917 4 stature stature NN cord-028721-x6f26ahr 917 5 is be VBZ cord-028721-x6f26ahr 917 6 short short JJ cord-028721-x6f26ahr 917 7 because because IN cord-028721-x6f26ahr 917 8 of of IN cord-028721-x6f26ahr 917 9 the the DT cord-028721-x6f26ahr 917 10 potent potent JJ cord-028721-x6f26ahr 917 11 ability ability NN cord-028721-x6f26ahr 917 12 of of IN cord-028721-x6f26ahr 917 13 androgens androgen NNS cord-028721-x6f26ahr 917 14 to to TO cord-028721-x6f26ahr 917 15 accelerate accelerate VB cord-028721-x6f26ahr 917 16 epiphyseal epiphyseal JJ cord-028721-x6f26ahr 917 17 closure closure NN cord-028721-x6f26ahr 917 18 . . . cord-028721-x6f26ahr 918 1 Most Most JJS cord-028721-x6f26ahr 918 2 males male NNS cord-028721-x6f26ahr 918 3 are be VBP cord-028721-x6f26ahr 918 4 fertile fertile JJ cord-028721-x6f26ahr 918 5 and and CC cord-028721-x6f26ahr 918 6 have have VBP cord-028721-x6f26ahr 918 7 normal normal JJ cord-028721-x6f26ahr 918 8 libido libido NN cord-028721-x6f26ahr 918 9 . . . cord-028721-x6f26ahr 919 1 407 407 CD cord-028721-x6f26ahr 920 1 Generally generally RB cord-028721-x6f26ahr 920 2 , , , cord-028721-x6f26ahr 920 3 the the DT cord-028721-x6f26ahr 920 4 inhibitory inhibitory JJ cord-028721-x6f26ahr 920 5 estrogenic estrogenic JJ cord-028721-x6f26ahr 920 6 effect effect NN cord-028721-x6f26ahr 920 7 on on IN cord-028721-x6f26ahr 920 8 testicular testicular JJ cord-028721-x6f26ahr 920 9 function function NN cord-028721-x6f26ahr 920 10 is be VBZ cord-028721-x6f26ahr 920 11 less less JJR cord-028721-x6f26ahr 920 12 than than IN cord-028721-x6f26ahr 920 13 that that DT cord-028721-x6f26ahr 920 14 observed observe VBN cord-028721-x6f26ahr 920 15 with with IN cord-028721-x6f26ahr 920 16 estrogen estrogen NN cord-028721-x6f26ahr 920 17 - - HYPH cord-028721-x6f26ahr 920 18 producing produce VBG cord-028721-x6f26ahr 920 19 tumors tumor NNS cord-028721-x6f26ahr 920 20 or or CC cord-028721-x6f26ahr 920 21 in in IN cord-028721-x6f26ahr 920 22 patients patient NNS cord-028721-x6f26ahr 920 23 treated treat VBN cord-028721-x6f26ahr 920 24 with with IN cord-028721-x6f26ahr 920 25 exogen exogen NNP cord-028721-x6f26ahr 920 26 estrogens estrogen NNS cord-028721-x6f26ahr 920 27 . . . cord-028721-x6f26ahr 921 1 Excessive excessive JJ cord-028721-x6f26ahr 921 2 aromatase aromatase NN cord-028721-x6f26ahr 921 3 caused cause VBN cord-028721-x6f26ahr 921 4 by by IN cord-028721-x6f26ahr 921 5 P450 p450 JJ cord-028721-x6f26ahr 921 6 mutation mutation NN cord-028721-x6f26ahr 921 7 induces induce VBZ cord-028721-x6f26ahr 921 8 alterations alteration NNS cord-028721-x6f26ahr 921 9 in in IN cord-028721-x6f26ahr 921 10 both both DT cord-028721-x6f26ahr 921 11 males male NNS cord-028721-x6f26ahr 921 12 and and CC cord-028721-x6f26ahr 921 13 females female NNS cord-028721-x6f26ahr 921 14 . . . cord-028721-x6f26ahr 922 1 In in IN cord-028721-x6f26ahr 922 2 females female NNS cord-028721-x6f26ahr 922 3 lacking lack VBG cord-028721-x6f26ahr 922 4 estrogens estrogen NNS cord-028721-x6f26ahr 922 5 owing owe VBG cord-028721-x6f26ahr 922 6 to to IN cord-028721-x6f26ahr 922 7 desmolase desmolase NNP cord-028721-x6f26ahr 922 8 defi defi NNP cord-028721-x6f26ahr 922 9 ciency ciency NNP cord-028721-x6f26ahr 922 10 , , , cord-028721-x6f26ahr 922 11 excessive excessive JJ cord-028721-x6f26ahr 922 12 aromatase aromatase NN cord-028721-x6f26ahr 922 13 leads lead VBZ cord-028721-x6f26ahr 922 14 to to IN cord-028721-x6f26ahr 922 15 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 922 16 and and CC cord-028721-x6f26ahr 922 17 progressive progressive JJ cord-028721-x6f26ahr 922 18 virilization virilization NN cord-028721-x6f26ahr 922 19 at at IN cord-028721-x6f26ahr 922 20 puberty puberty NN cord-028721-x6f26ahr 922 21 ; ; : cord-028721-x6f26ahr 922 22 conversely conversely RB cord-028721-x6f26ahr 922 23 , , , cord-028721-x6f26ahr 922 24 pubertal pubertal JJ cord-028721-x6f26ahr 922 25 development development NN cord-028721-x6f26ahr 922 26 is be VBZ cord-028721-x6f26ahr 922 27 normal normal JJ cord-028721-x6f26ahr 922 28 in in IN cord-028721-x6f26ahr 922 29 males male NNS cord-028721-x6f26ahr 922 30 . . . cord-028721-x6f26ahr 923 1 In in IN cord-028721-x6f26ahr 923 2 children child NNS cord-028721-x6f26ahr 923 3 , , , cord-028721-x6f26ahr 923 4 FSH fsh NN cord-028721-x6f26ahr 923 5 and and CC cord-028721-x6f26ahr 923 6 LH LH NNP cord-028721-x6f26ahr 923 7 levels level NNS cord-028721-x6f26ahr 923 8 and and CC cord-028721-x6f26ahr 923 9 gonadotropin gonadotropin NN cord-028721-x6f26ahr 923 10 response response NN cord-028721-x6f26ahr 923 11 to to IN cord-028721-x6f26ahr 923 12 GnRH GnRH NNP cord-028721-x6f26ahr 923 13 are be VBP cord-028721-x6f26ahr 923 14 normal normal JJ cord-028721-x6f26ahr 923 15 , , , cord-028721-x6f26ahr 923 16 suggesting suggest VBG cord-028721-x6f26ahr 923 17 that that IN cord-028721-x6f26ahr 923 18 the the DT cord-028721-x6f26ahr 923 19 role role NN cord-028721-x6f26ahr 923 20 of of IN cord-028721-x6f26ahr 923 21 estrogens estrogen NNS cord-028721-x6f26ahr 923 22 in in IN cord-028721-x6f26ahr 923 23 pituitary pituitary JJ cord-028721-x6f26ahr 923 24 regulation regulation NN cord-028721-x6f26ahr 923 25 is be VBZ cord-028721-x6f26ahr 923 26 weak weak JJ cord-028721-x6f26ahr 923 27 during during IN cord-028721-x6f26ahr 923 28 infancy infancy NN cord-028721-x6f26ahr 923 29 . . . cord-028721-x6f26ahr 924 1 408 408 CD cord-028721-x6f26ahr 925 1 In in IN cord-028721-x6f26ahr 925 2 both both DT cord-028721-x6f26ahr 925 3 genders gender NNS cord-028721-x6f26ahr 925 4 , , , cord-028721-x6f26ahr 925 5 epiphyseal epiphyseal NN cord-028721-x6f26ahr 925 6 closure closure NN cord-028721-x6f26ahr 925 7 is be VBZ cord-028721-x6f26ahr 925 8 delayed delay VBN cord-028721-x6f26ahr 925 9 and and CC cord-028721-x6f26ahr 925 10 a a DT cord-028721-x6f26ahr 925 11 eunuchoid eunuchoid JJ cord-028721-x6f26ahr 925 12 habitus habitus NN cord-028721-x6f26ahr 925 13 results result NNS cord-028721-x6f26ahr 925 14 . . . cord-028721-x6f26ahr 926 1 Adult adult NN cord-028721-x6f26ahr 926 2 males male NNS cord-028721-x6f26ahr 926 3 have have VBP cord-028721-x6f26ahr 926 4 small small JJ cord-028721-x6f26ahr 926 5 testes testis NNS cord-028721-x6f26ahr 926 6 , , , cord-028721-x6f26ahr 926 7 severe severe JJ cord-028721-x6f26ahr 926 8 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 926 9 , , , cord-028721-x6f26ahr 926 10 and and CC cord-028721-x6f26ahr 926 11 complete complete JJ cord-028721-x6f26ahr 926 12 asthenozoospermia asthenozoospermia NN cord-028721-x6f26ahr 926 13 ; ; : cord-028721-x6f26ahr 926 14 FSH fsh NN cord-028721-x6f26ahr 926 15 and and CC cord-028721-x6f26ahr 926 16 LH LH NNP cord-028721-x6f26ahr 926 17 levels level NNS cord-028721-x6f26ahr 926 18 are be VBP cord-028721-x6f26ahr 926 19 high high JJ cord-028721-x6f26ahr 926 20 , , , cord-028721-x6f26ahr 926 21 testosterone testosterone NN cord-028721-x6f26ahr 926 22 levels level NNS cord-028721-x6f26ahr 926 23 are be VBP cord-028721-x6f26ahr 926 24 normal normal JJ cord-028721-x6f26ahr 926 25 , , , cord-028721-x6f26ahr 926 26 and and CC cord-028721-x6f26ahr 926 27 serum serum NN cord-028721-x6f26ahr 926 28 estrogen estrogen NN cord-028721-x6f26ahr 926 29 levels level NNS cord-028721-x6f26ahr 926 30 are be VBP cord-028721-x6f26ahr 926 31 very very RB cord-028721-x6f26ahr 926 32 low low JJ cord-028721-x6f26ahr 926 33 . . . cord-028721-x6f26ahr 927 1 All all DT cord-028721-x6f26ahr 927 2 patients patient NNS cord-028721-x6f26ahr 927 3 with with IN cord-028721-x6f26ahr 927 4 excessive excessive JJ cord-028721-x6f26ahr 927 5 aromatase aromatase NN cord-028721-x6f26ahr 927 6 have have VBP cord-028721-x6f26ahr 927 7 short short JJ cord-028721-x6f26ahr 927 8 stature stature NN cord-028721-x6f26ahr 927 9 , , , cord-028721-x6f26ahr 927 10 with with IN cord-028721-x6f26ahr 927 11 continuing continue VBG cord-028721-x6f26ahr 927 12 linear linear JJ cord-028721-x6f26ahr 927 13 growth growth NN cord-028721-x6f26ahr 927 14 into into IN cord-028721-x6f26ahr 927 15 adulthood adulthood NN cord-028721-x6f26ahr 927 16 , , , cord-028721-x6f26ahr 927 17 unfused unfused JJ cord-028721-x6f26ahr 927 18 epiphyses epiphysis NNS cord-028721-x6f26ahr 927 19 , , , cord-028721-x6f26ahr 927 20 osteoporosis osteoporosis NN cord-028721-x6f26ahr 927 21 , , , cord-028721-x6f26ahr 927 22 bilateral bilateral JJ cord-028721-x6f26ahr 927 23 genu genu NNP cord-028721-x6f26ahr 927 24 valgum valgum NNP cord-028721-x6f26ahr 927 25 , , , cord-028721-x6f26ahr 927 26 and and CC cord-028721-x6f26ahr 927 27 eunuchoid eunuchoid JJ cord-028721-x6f26ahr 927 28 proportions proportion NNS cord-028721-x6f26ahr 927 29 . . . cord-028721-x6f26ahr 928 1 The the DT cord-028721-x6f26ahr 928 2 testes testis NNS cord-028721-x6f26ahr 928 3 show show VBP cord-028721-x6f26ahr 928 4 macroorchidism macroorchidism NN cord-028721-x6f26ahr 928 5 with with IN cord-028721-x6f26ahr 928 6 normal normal JJ cord-028721-x6f26ahr 928 7 testicular testicular JJ cord-028721-x6f26ahr 928 8 consistency consistency NN cord-028721-x6f26ahr 928 9 in in IN cord-028721-x6f26ahr 928 10 some some DT cord-028721-x6f26ahr 928 11 cases case NNS cord-028721-x6f26ahr 928 12 , , , cord-028721-x6f26ahr 928 13 409 409 CD cord-028721-x6f26ahr 928 14 and and CC cord-028721-x6f26ahr 928 15 are be VBP cord-028721-x6f26ahr 928 16 small small JJ cord-028721-x6f26ahr 928 17 with with IN cord-028721-x6f26ahr 928 18 severe severe JJ cord-028721-x6f26ahr 928 19 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 928 20 and and CC cord-028721-x6f26ahr 928 21 100 100 CD cord-028721-x6f26ahr 928 22 % % NN cord-028721-x6f26ahr 928 23 immotile immotile NN cord-028721-x6f26ahr 928 24 spermatozoa spermatozoa VBG cord-028721-x6f26ahr 928 25 in in IN cord-028721-x6f26ahr 928 26 other other JJ cord-028721-x6f26ahr 928 27 cases case NNS cord-028721-x6f26ahr 928 28 . . . cord-028721-x6f26ahr 929 1 410 410 CD cord-028721-x6f26ahr 929 2 A a DT cord-028721-x6f26ahr 929 3 syndrome syndrome NN cord-028721-x6f26ahr 929 4 similar similar JJ cord-028721-x6f26ahr 929 5 to to IN cord-028721-x6f26ahr 929 6 that that DT cord-028721-x6f26ahr 929 7 of of IN cord-028721-x6f26ahr 929 8 excessive excessive JJ cord-028721-x6f26ahr 929 9 aromatase aromatase JJ cord-028721-x6f26ahr 929 10 production production NN cord-028721-x6f26ahr 929 11 is be VBZ cord-028721-x6f26ahr 929 12 found find VBN cord-028721-x6f26ahr 929 13 in in IN cord-028721-x6f26ahr 929 14 patients patient NNS cord-028721-x6f26ahr 929 15 with with IN cord-028721-x6f26ahr 929 16 estrogen estrogen NN cord-028721-x6f26ahr 929 17 resistance resistance NN cord-028721-x6f26ahr 929 18 caused cause VBN cord-028721-x6f26ahr 929 19 by by IN cord-028721-x6f26ahr 929 20 disruptive disruptive JJ cord-028721-x6f26ahr 929 21 mutations mutation NNS cord-028721-x6f26ahr 929 22 of of IN cord-028721-x6f26ahr 929 23 the the DT cord-028721-x6f26ahr 929 24 ER ER NNP cord-028721-x6f26ahr 929 25 gene gene NN cord-028721-x6f26ahr 929 26 . . . cord-028721-x6f26ahr 930 1 These these DT cord-028721-x6f26ahr 930 2 patients patient NNS cord-028721-x6f26ahr 930 3 show show VBP cord-028721-x6f26ahr 930 4 macroorchidism macroorchidism NN cord-028721-x6f26ahr 930 5 , , , cord-028721-x6f26ahr 930 6 elevated elevated JJ cord-028721-x6f26ahr 930 7 testosterone testosterone NN cord-028721-x6f26ahr 930 8 levels level NNS cord-028721-x6f26ahr 930 9 , , , cord-028721-x6f26ahr 930 10 and and CC cord-028721-x6f26ahr 930 11 increased increase VBN cord-028721-x6f26ahr 930 12 levels level NNS cord-028721-x6f26ahr 930 13 of of IN cord-028721-x6f26ahr 930 14 FSH fsh NN cord-028721-x6f26ahr 930 15 , , , cord-028721-x6f26ahr 930 16 LH LH NNP cord-028721-x6f26ahr 930 17 , , , cord-028721-x6f26ahr 930 18 estradiol estradiol NN cord-028721-x6f26ahr 930 19 , , , cord-028721-x6f26ahr 930 20 and and CC cord-028721-x6f26ahr 930 21 estrona estrona NNP cord-028721-x6f26ahr 930 22 . . . cord-028721-x6f26ahr 931 1 411 411 CD cord-028721-x6f26ahr 932 1 Precocious precocious JJ cord-028721-x6f26ahr 932 2 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 932 3 secondary secondary JJ cord-028721-x6f26ahr 932 4 to to IN cord-028721-x6f26ahr 932 5 Leydig leydig NN cord-028721-x6f26ahr 932 6 cell cell NN cord-028721-x6f26ahr 932 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 932 8 with with IN cord-028721-x6f26ahr 932 9 focal focal JJ cord-028721-x6f26ahr 932 10 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 932 11 This this DT cord-028721-x6f26ahr 932 12 entity entity NN cord-028721-x6f26ahr 932 13 can can MD cord-028721-x6f26ahr 932 14 present present VB cord-028721-x6f26ahr 932 15 with with IN cord-028721-x6f26ahr 932 16 clinical clinical JJ cord-028721-x6f26ahr 932 17 symptoms symptom NNS cord-028721-x6f26ahr 932 18 similar similar JJ cord-028721-x6f26ahr 932 19 to to IN cord-028721-x6f26ahr 932 20 those those DT cord-028721-x6f26ahr 932 21 of of IN cord-028721-x6f26ahr 932 22 a a DT cord-028721-x6f26ahr 932 23 functioning function VBG cord-028721-x6f26ahr 932 24 Leydig Leydig NNP cord-028721-x6f26ahr 932 25 cell cell NN cord-028721-x6f26ahr 932 26 tumor tumor NN cord-028721-x6f26ahr 932 27 ; ; : cord-028721-x6f26ahr 932 28 this this DT cord-028721-x6f26ahr 932 29 is be VBZ cord-028721-x6f26ahr 932 30 a a DT cord-028721-x6f26ahr 932 31 precocious precocious JJ cord-028721-x6f26ahr 932 32 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 932 33 with with IN cord-028721-x6f26ahr 932 34 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 932 35 testicular testicular JJ cord-028721-x6f26ahr 932 36 enlargement enlargement NN cord-028721-x6f26ahr 932 37 . . . cord-028721-x6f26ahr 933 1 412 412 CD cord-028721-x6f26ahr 934 1 The the DT cord-028721-x6f26ahr 934 2 testes testis NNS cord-028721-x6f26ahr 934 3 contains contain VBZ cord-028721-x6f26ahr 934 4 hypertrophic hypertrophic JJ cord-028721-x6f26ahr 934 5 Leydig Leydig NNP cord-028721-x6f26ahr 934 6 cell cell NN cord-028721-x6f26ahr 934 7 nests nest NNS cord-028721-x6f26ahr 934 8 in in IN cord-028721-x6f26ahr 934 9 association association NN cord-028721-x6f26ahr 934 10 with with IN cord-028721-x6f26ahr 934 11 normal normal JJ cord-028721-x6f26ahr 934 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 934 13 . . . cord-028721-x6f26ahr 935 1 No no DT cord-028721-x6f26ahr 935 2 tumoral tumoral JJ cord-028721-x6f26ahr 935 3 mass mass NN cord-028721-x6f26ahr 935 4 is be VBZ cord-028721-x6f26ahr 935 5 seen see VBN cord-028721-x6f26ahr 935 6 . . . cord-028721-x6f26ahr 936 1 Leydig leydig NN cord-028721-x6f26ahr 936 2 cells cell NNS cord-028721-x6f26ahr 936 3 do do VBP cord-028721-x6f26ahr 936 4 not not RB cord-028721-x6f26ahr 936 5 contain contain VB cord-028721-x6f26ahr 936 6 Reinke Reinke NNP cord-028721-x6f26ahr 936 7 's 's POS cord-028721-x6f26ahr 936 8 crystalloids crystalloid NNS cord-028721-x6f26ahr 936 9 and and CC cord-028721-x6f26ahr 936 10 do do VBP cord-028721-x6f26ahr 936 11 not not RB cord-028721-x6f26ahr 936 12 compress compress VB cord-028721-x6f26ahr 936 13 the the DT cord-028721-x6f26ahr 936 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 936 15 tubules tubule NNS cord-028721-x6f26ahr 936 16 . . . cord-028721-x6f26ahr 937 1 There there EX cord-028721-x6f26ahr 937 2 is be VBZ cord-028721-x6f26ahr 937 3 a a DT cord-028721-x6f26ahr 937 4 clear clear JJ cord-028721-x6f26ahr 937 5 delimitation delimitation NN cord-028721-x6f26ahr 937 6 between between IN cord-028721-x6f26ahr 937 7 tubules tubule NNS cord-028721-x6f26ahr 937 8 with with IN cord-028721-x6f26ahr 937 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 937 10 and and CC cord-028721-x6f26ahr 937 11 infantile infantile JJ cord-028721-x6f26ahr 937 12 immature immature JJ cord-028721-x6f26ahr 937 13 tubules tubule NNS cord-028721-x6f26ahr 937 14 . . . cord-028721-x6f26ahr 938 1 The the DT cord-028721-x6f26ahr 938 2 differential differential JJ cord-028721-x6f26ahr 938 3 diagnosis diagnosis NN cord-028721-x6f26ahr 938 4 between between IN cord-028721-x6f26ahr 938 5 this this DT cord-028721-x6f26ahr 938 6 entity entity NN cord-028721-x6f26ahr 938 7 and and CC cord-028721-x6f26ahr 938 8 Leydig Leydig NNP cord-028721-x6f26ahr 938 9 cell cell NN cord-028721-x6f26ahr 938 10 tumor tumor NN cord-028721-x6f26ahr 938 11 with with IN cord-028721-x6f26ahr 938 12 precocious precocious JJ cord-028721-x6f26ahr 938 13 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 938 14 is be VBZ cord-028721-x6f26ahr 938 15 based base VBN cord-028721-x6f26ahr 938 16 on on IN cord-028721-x6f26ahr 938 17 the the DT cord-028721-x6f26ahr 938 18 histological histological JJ cord-028721-x6f26ahr 938 19 pattern pattern NN cord-028721-x6f26ahr 938 20 . . . cord-028721-x6f26ahr 939 1 Open Open NNP cord-028721-x6f26ahr 939 2 excisional excisional JJ cord-028721-x6f26ahr 939 3 testicular testicular JJ cord-028721-x6f26ahr 939 4 biopsy biopsy NN cord-028721-x6f26ahr 939 5 is be VBZ cord-028721-x6f26ahr 939 6 recommended recommend VBN cord-028721-x6f26ahr 939 7 ; ; : cord-028721-x6f26ahr 939 8 if if IN cord-028721-x6f26ahr 939 9 there there EX cord-028721-x6f26ahr 939 10 is be VBZ cord-028721-x6f26ahr 939 11 Leydig Leydig NNP cord-028721-x6f26ahr 939 12 cell cell NN cord-028721-x6f26ahr 939 13 tumor tumor NN cord-028721-x6f26ahr 939 14 , , , cord-028721-x6f26ahr 939 15 or or CC cord-028721-x6f26ahr 939 16 the the DT cord-028721-x6f26ahr 939 17 diagnosis diagnosis NN cord-028721-x6f26ahr 939 18 by by IN cord-028721-x6f26ahr 939 19 frozen frozen JJ cord-028721-x6f26ahr 939 20 section section NN cord-028721-x6f26ahr 939 21 is be VBZ cord-028721-x6f26ahr 939 22 not not RB cord-028721-x6f26ahr 939 23 conclusive conclusive JJ cord-028721-x6f26ahr 939 24 , , , cord-028721-x6f26ahr 939 25 removal removal NN cord-028721-x6f26ahr 939 26 is be VBZ cord-028721-x6f26ahr 939 27 advisable advisable JJ cord-028721-x6f26ahr 939 28 . . . cord-028721-x6f26ahr 940 1 413 413 CD cord-028721-x6f26ahr 941 1 There there EX cord-028721-x6f26ahr 941 2 are be VBP cord-028721-x6f26ahr 941 3 no no DT cord-028721-x6f26ahr 941 4 data data NN cord-028721-x6f26ahr 941 5 to to TO cord-028721-x6f26ahr 941 6 suggest suggest VB cord-028721-x6f26ahr 941 7 that that IN cord-028721-x6f26ahr 941 8 this this DT cord-028721-x6f26ahr 941 9 hyperplasia hyperplasia NN cord-028721-x6f26ahr 941 10 might may MD cord-028721-x6f26ahr 941 11 develop develop VB cord-028721-x6f26ahr 941 12 into into IN cord-028721-x6f26ahr 941 13 Leydig Leydig NNP cord-028721-x6f26ahr 941 14 cell cell NN cord-028721-x6f26ahr 941 15 tumor tumor NN cord-028721-x6f26ahr 941 16 . . . cord-028721-x6f26ahr 942 1 Mixed mixed JJ cord-028721-x6f26ahr 942 2 precocious precocious JJ cord-028721-x6f26ahr 942 3 puberty puberty NN cord-028721-x6f26ahr 943 1 The the DT cord-028721-x6f26ahr 943 2 best well RBS cord-028721-x6f26ahr 943 3 known know VBN cord-028721-x6f26ahr 943 4 form form NN cord-028721-x6f26ahr 943 5 is be VBZ cord-028721-x6f26ahr 943 6 the the DT cord-028721-x6f26ahr 943 7 McCune McCune NNP cord-028721-x6f26ahr 943 8 - - HYPH cord-028721-x6f26ahr 943 9 Albright Albright NNP cord-028721-x6f26ahr 943 10 syndrome syndrome NN cord-028721-x6f26ahr 943 11 ( ( -LRB- cord-028721-x6f26ahr 943 12 MAS MAS NNP cord-028721-x6f26ahr 943 13 ) ) -RRB- cord-028721-x6f26ahr 943 14 , , , cord-028721-x6f26ahr 943 15 characterized characterize VBN cord-028721-x6f26ahr 943 16 by by IN cord-028721-x6f26ahr 943 17 the the DT cord-028721-x6f26ahr 943 18 association association NNP cord-028721-x6f26ahr 943 19 of of IN cord-028721-x6f26ahr 943 20 ' ' `` cord-028721-x6f26ahr 943 21 coffee coffee NN cord-028721-x6f26ahr 943 22 and and CC cord-028721-x6f26ahr 943 23 milk milk NN cord-028721-x6f26ahr 943 24 ' ' POS cord-028721-x6f26ahr 943 25 pigmentary pigmentary JJ cord-028721-x6f26ahr 943 26 lesions lesion NNS cord-028721-x6f26ahr 943 27 in in IN cord-028721-x6f26ahr 943 28 the the DT cord-028721-x6f26ahr 943 29 skin skin NN cord-028721-x6f26ahr 943 30 , , , cord-028721-x6f26ahr 943 31 bone bone NN cord-028721-x6f26ahr 943 32 lesions lesion NNS cord-028721-x6f26ahr 943 33 ( ( -LRB- cord-028721-x6f26ahr 943 34 polyostotic polyostotic NNP cord-028721-x6f26ahr 943 35 fi fi NNP cord-028721-x6f26ahr 943 36 brous brous JJ cord-028721-x6f26ahr 943 37 dysplasia dysplasia NNP cord-028721-x6f26ahr 943 38 ) ) -RRB- cord-028721-x6f26ahr 943 39 , , , cord-028721-x6f26ahr 943 40 enlarged enlarged JJ cord-028721-x6f26ahr 943 41 testes testis NNS cord-028721-x6f26ahr 943 42 , , , cord-028721-x6f26ahr 943 43 prepubertal prepubertal JJ cord-028721-x6f26ahr 943 44 size size NN cord-028721-x6f26ahr 943 45 of of IN cord-028721-x6f26ahr 943 46 the the DT cord-028721-x6f26ahr 943 47 penis penis NN cord-028721-x6f26ahr 943 48 , , , cord-028721-x6f26ahr 943 49 and and CC cord-028721-x6f26ahr 943 50 absence absence NN cord-028721-x6f26ahr 943 51 of of IN cord-028721-x6f26ahr 943 52 pubic pubic NN cord-028721-x6f26ahr 943 53 and and CC cord-028721-x6f26ahr 943 54 axillary axillary JJ cord-028721-x6f26ahr 943 55 hair hair NN cord-028721-x6f26ahr 943 56 . . . cord-028721-x6f26ahr 944 1 Although although IN cord-028721-x6f26ahr 944 2 testicular testicular JJ cord-028721-x6f26ahr 944 3 enlargement enlargement NN cord-028721-x6f26ahr 944 4 is be VBZ cord-028721-x6f26ahr 944 5 usually usually RB cord-028721-x6f26ahr 944 6 bilateral bilateral JJ cord-028721-x6f26ahr 944 7 , , , cord-028721-x6f26ahr 944 8 unilateral unilateral JJ cord-028721-x6f26ahr 944 9 macroorchidism macroorchidism NN cord-028721-x6f26ahr 944 10 may may MD cord-028721-x6f26ahr 944 11 be be VB cord-028721-x6f26ahr 944 12 the the DT cord-028721-x6f26ahr 944 13 fi fi NN cord-028721-x6f26ahr 944 14 rst rst NN cord-028721-x6f26ahr 944 15 symptom symptom NN cord-028721-x6f26ahr 944 16 . . . cord-028721-x6f26ahr 945 1 414 414 CD cord-028721-x6f26ahr 946 1 An an DT cord-028721-x6f26ahr 946 2 interesting interesting JJ cord-028721-x6f26ahr 946 3 fi fi NN cord-028721-x6f26ahr 946 4 nding nding NN cord-028721-x6f26ahr 946 5 is be VBZ cord-028721-x6f26ahr 946 6 that that IN cord-028721-x6f26ahr 946 7 the the DT cord-028721-x6f26ahr 946 8 onset onset NN cord-028721-x6f26ahr 946 9 of of IN cord-028721-x6f26ahr 946 10 testicular testicular JJ cord-028721-x6f26ahr 946 11 maturation maturation NN cord-028721-x6f26ahr 946 12 is be VBZ cord-028721-x6f26ahr 946 13 induced induce VBN cord-028721-x6f26ahr 946 14 by by IN cord-028721-x6f26ahr 946 15 the the DT cord-028721-x6f26ahr 946 16 testis testis NN cord-028721-x6f26ahr 946 17 itself -PRON- PRP cord-028721-x6f26ahr 946 18 , , , cord-028721-x6f26ahr 946 19 which which WDT cord-028721-x6f26ahr 946 20 produces produce VBZ cord-028721-x6f26ahr 946 21 steroid steroid NN cord-028721-x6f26ahr 946 22 secretion secretion NN cord-028721-x6f26ahr 946 23 due due IN cord-028721-x6f26ahr 946 24 to to IN cord-028721-x6f26ahr 946 25 autonomous autonomous JJ cord-028721-x6f26ahr 946 26 hyperfunction hyperfunction NN cord-028721-x6f26ahr 946 27 of of IN cord-028721-x6f26ahr 946 28 Sertoli Sertoli NNP cord-028721-x6f26ahr 946 29 cells cell NNS cord-028721-x6f26ahr 946 30 without without IN cord-028721-x6f26ahr 946 31 evidence evidence NN cord-028721-x6f26ahr 946 32 of of IN cord-028721-x6f26ahr 946 33 Leydig Leydig NNP cord-028721-x6f26ahr 946 34 cell cell NN cord-028721-x6f26ahr 946 35 involvement involvement NN cord-028721-x6f26ahr 946 36 . . . cord-028721-x6f26ahr 947 1 415 415 CD cord-028721-x6f26ahr 948 1 This this DT cord-028721-x6f26ahr 948 2 secretion secretion NN cord-028721-x6f26ahr 948 3 causes cause VBZ cord-028721-x6f26ahr 948 4 early early JJ cord-028721-x6f26ahr 948 5 maturation maturation NN cord-028721-x6f26ahr 948 6 of of IN cord-028721-x6f26ahr 948 7 the the DT cord-028721-x6f26ahr 948 8 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 948 9 - - HYPH cord-028721-x6f26ahr 948 10 testicular testicular JJ cord-028721-x6f26ahr 948 11 axis axis NN cord-028721-x6f26ahr 948 12 and and CC cord-028721-x6f26ahr 948 13 , , , cord-028721-x6f26ahr 948 14 subsequently subsequently RB cord-028721-x6f26ahr 948 15 , , , cord-028721-x6f26ahr 948 16 true true JJ cord-028721-x6f26ahr 948 17 precocious precocious JJ cord-028721-x6f26ahr 948 18 puberty puberty NN cord-028721-x6f26ahr 948 19 . . . cord-028721-x6f26ahr 949 1 416 416 CD cord-028721-x6f26ahr 950 1 Serum serum NN cord-028721-x6f26ahr 950 2 levels level NNS cord-028721-x6f26ahr 950 3 of of IN cord-028721-x6f26ahr 950 4 testosterone testosterone NN cord-028721-x6f26ahr 950 5 are be VBP cord-028721-x6f26ahr 950 6 low low JJ cord-028721-x6f26ahr 950 7 , , , cord-028721-x6f26ahr 950 8 but but CC cord-028721-x6f26ahr 950 9 those those DT cord-028721-x6f26ahr 950 10 of of IN cord-028721-x6f26ahr 950 11 inhibin inhibin NNP cord-028721-x6f26ahr 950 12 B B NNP cord-028721-x6f26ahr 950 13 and and CC cord-028721-x6f26ahr 950 14 AMH AMH NNP cord-028721-x6f26ahr 950 15 are be VBP cord-028721-x6f26ahr 950 16 abnormally abnormally RB cord-028721-x6f26ahr 950 17 increased increase VBN cord-028721-x6f26ahr 950 18 . . . cord-028721-x6f26ahr 951 1 This this DT cord-028721-x6f26ahr 951 2 syndrome syndrome NN cord-028721-x6f26ahr 951 3 is be VBZ cord-028721-x6f26ahr 951 4 caused cause VBN cord-028721-x6f26ahr 951 5 by by IN cord-028721-x6f26ahr 951 6 mutations mutation NNS cord-028721-x6f26ahr 951 7 that that WDT cord-028721-x6f26ahr 951 8 activate activate VBP cord-028721-x6f26ahr 951 9 the the DT cord-028721-x6f26ahr 951 10 GNAS-1 GNAS-1 NNP cord-028721-x6f26ahr 951 11 gene gene NN cord-028721-x6f26ahr 951 12 , , , cord-028721-x6f26ahr 951 13 which which WDT cord-028721-x6f26ahr 951 14 encodes encode VBZ cord-028721-x6f26ahr 951 15 the the DT cord-028721-x6f26ahr 951 16 α α NNP cord-028721-x6f26ahr 951 17 subunit subunit NN cord-028721-x6f26ahr 951 18 of of IN cord-028721-x6f26ahr 951 19 the the DT cord-028721-x6f26ahr 951 20 trimeric trimeric NNP cord-028721-x6f26ahr 951 21 G g NN cord-028721-x6f26ahr 951 22 - - HYPH cord-028721-x6f26ahr 951 23 protein protein NN cord-028721-x6f26ahr 951 24 . . . cord-028721-x6f26ahr 952 1 Because because IN cord-028721-x6f26ahr 952 2 mutations mutation NNS cord-028721-x6f26ahr 952 3 are be VBP cord-028721-x6f26ahr 952 4 lethal lethal JJ cord-028721-x6f26ahr 952 5 in in IN cord-028721-x6f26ahr 952 6 the the DT cord-028721-x6f26ahr 952 7 uterus uterus NN cord-028721-x6f26ahr 952 8 , , , cord-028721-x6f26ahr 952 9 those those DT cord-028721-x6f26ahr 952 10 subjects subject NNS cord-028721-x6f26ahr 952 11 producing produce VBG cord-028721-x6f26ahr 952 12 AMH AMH NNP cord-028721-x6f26ahr 952 13 bear bear VBP cord-028721-x6f26ahr 952 14 a a DT cord-028721-x6f26ahr 952 15 mosaicism mosaicism NN cord-028721-x6f26ahr 952 16 chromosomal chromosomal JJ cord-028721-x6f26ahr 952 17 constitution constitution NN cord-028721-x6f26ahr 952 18 for for IN cord-028721-x6f26ahr 952 19 this this DT cord-028721-x6f26ahr 952 20 defi defi NNP cord-028721-x6f26ahr 952 21 ciency ciency NNP cord-028721-x6f26ahr 952 22 . . . cord-028721-x6f26ahr 953 1 A a DT cord-028721-x6f26ahr 953 2 testis testis NN cord-028721-x6f26ahr 953 3 is be VBZ cord-028721-x6f26ahr 953 4 ectopic ectopic JJ cord-028721-x6f26ahr 953 5 when when WRB cord-028721-x6f26ahr 953 6 it -PRON- PRP cord-028721-x6f26ahr 953 7 is be VBZ cord-028721-x6f26ahr 953 8 in in IN cord-028721-x6f26ahr 953 9 a a DT cord-028721-x6f26ahr 953 10 location location NN cord-028721-x6f26ahr 953 11 outside outside IN cord-028721-x6f26ahr 953 12 the the DT cord-028721-x6f26ahr 953 13 normal normal JJ cord-028721-x6f26ahr 953 14 path path NN cord-028721-x6f26ahr 953 15 of of IN cord-028721-x6f26ahr 953 16 descent descent NN cord-028721-x6f26ahr 953 17 . . . cord-028721-x6f26ahr 954 1 Unlike unlike IN cord-028721-x6f26ahr 954 2 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 954 3 testes testis NNS cord-028721-x6f26ahr 954 4 , , , cord-028721-x6f26ahr 954 5 ectopic ectopic JJ cord-028721-x6f26ahr 954 6 testes testis NNS cord-028721-x6f26ahr 954 7 are be VBP cord-028721-x6f26ahr 954 8 nearly nearly RB cord-028721-x6f26ahr 954 9 normal normal JJ cord-028721-x6f26ahr 954 10 in in IN cord-028721-x6f26ahr 954 11 size size NN cord-028721-x6f26ahr 954 12 and and CC cord-028721-x6f26ahr 954 13 are be VBP cord-028721-x6f26ahr 954 14 accompanied accompany VBN cord-028721-x6f26ahr 954 15 by by IN cord-028721-x6f26ahr 954 16 a a DT cord-028721-x6f26ahr 954 17 spermatic spermatic JJ cord-028721-x6f26ahr 954 18 cord cord NN cord-028721-x6f26ahr 954 19 that that WDT cord-028721-x6f26ahr 954 20 is be VBZ cord-028721-x6f26ahr 954 21 normal normal JJ cord-028721-x6f26ahr 954 22 or or CC cord-028721-x6f26ahr 954 23 even even RB cord-028721-x6f26ahr 954 24 longer long RBR cord-028721-x6f26ahr 954 25 than than IN cord-028721-x6f26ahr 954 26 normal normal JJ cord-028721-x6f26ahr 954 27 , , , cord-028721-x6f26ahr 954 28 and and CC cord-028721-x6f26ahr 954 29 by by IN cord-028721-x6f26ahr 954 30 a a DT cord-028721-x6f26ahr 954 31 normal normal JJ cord-028721-x6f26ahr 954 32 scrotum scrotum NN cord-028721-x6f26ahr 954 33 . . . cord-028721-x6f26ahr 955 1 417 417 CD cord-028721-x6f26ahr 955 2 Testicular Testicular NNP cord-028721-x6f26ahr 955 3 ectopia ectopia NNP cord-028721-x6f26ahr 955 4 is be VBZ cord-028721-x6f26ahr 955 5 classifi classifi NNP cord-028721-x6f26ahr 955 6 ed ed NNP cord-028721-x6f26ahr 956 1 according accord VBG cord-028721-x6f26ahr 956 2 to to IN cord-028721-x6f26ahr 956 3 location location NN cord-028721-x6f26ahr 956 4 ; ; : cord-028721-x6f26ahr 956 5 [ [ -LRB- cord-028721-x6f26ahr 956 6 418 418 CD cord-028721-x6f26ahr 956 7 ] ] -RRB- cord-028721-x6f26ahr 956 8 [ [ -LRB- cord-028721-x6f26ahr 956 9 419 419 CD cord-028721-x6f26ahr 956 10 ] ] -RRB- cord-028721-x6f26ahr 956 11 [ [ -LRB- cord-028721-x6f26ahr 956 12 420 420 CD cord-028721-x6f26ahr 956 13 ] ] -RRB- cord-028721-x6f26ahr 957 1 [ [ -LRB- cord-028721-x6f26ahr 957 2 421 421 CD cord-028721-x6f26ahr 957 3 ] ] -RRB- cord-028721-x6f26ahr 957 4 [ [ -LRB- cord-028721-x6f26ahr 957 5 422 422 CD cord-028721-x6f26ahr 957 6 ] ] -RRB- cord-028721-x6f26ahr 957 7 in in IN cord-028721-x6f26ahr 957 8 decreasing decrease VBG cord-028721-x6f26ahr 957 9 order order NN cord-028721-x6f26ahr 957 10 of of IN cord-028721-x6f26ahr 957 11 frequency frequency NN cord-028721-x6f26ahr 957 12 , , , cord-028721-x6f26ahr 957 13 the the DT cord-028721-x6f26ahr 957 14 major major JJ cord-028721-x6f26ahr 957 15 types type NNS cord-028721-x6f26ahr 957 16 are be VBP cord-028721-x6f26ahr 957 17 : : : cord-028721-x6f26ahr 957 18 • • XX cord-028721-x6f26ahr 958 1 Interstitial interstitial JJ cord-028721-x6f26ahr 958 2 or or CC cord-028721-x6f26ahr 958 3 inguinal inguinal JJ cord-028721-x6f26ahr 958 4 superfi superfi NNS cord-028721-x6f26ahr 959 1 cial cial NNP cord-028721-x6f26ahr 959 2 ectopia ectopia NNP cord-028721-x6f26ahr 959 3 . . . cord-028721-x6f26ahr 960 1 This this DT cord-028721-x6f26ahr 960 2 is be VBZ cord-028721-x6f26ahr 960 3 the the DT cord-028721-x6f26ahr 960 4 most most RBS cord-028721-x6f26ahr 960 5 frequent frequent JJ cord-028721-x6f26ahr 960 6 form form NN cord-028721-x6f26ahr 960 7 and and CC cord-028721-x6f26ahr 960 8 may may MD cord-028721-x6f26ahr 960 9 be be VB cord-028721-x6f26ahr 960 10 confused confuse VBN cord-028721-x6f26ahr 960 11 with with IN cord-028721-x6f26ahr 960 12 inguinal inguinal JJ cord-028721-x6f26ahr 960 13 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 960 14 . . . cord-028721-x6f26ahr 961 1 After after IN cord-028721-x6f26ahr 961 2 passing pass VBG cord-028721-x6f26ahr 961 3 through through IN cord-028721-x6f26ahr 961 4 the the DT cord-028721-x6f26ahr 961 5 outer outer JJ cord-028721-x6f26ahr 961 6 genital genital NN cord-028721-x6f26ahr 961 7 opening opening NN cord-028721-x6f26ahr 961 8 , , , cord-028721-x6f26ahr 961 9 the the DT cord-028721-x6f26ahr 961 10 testis testis NN cord-028721-x6f26ahr 961 11 ascends ascend VBZ cord-028721-x6f26ahr 961 12 to to IN cord-028721-x6f26ahr 961 13 the the DT cord-028721-x6f26ahr 961 14 anterosuperior anterosuperior NNP cord-028721-x6f26ahr 961 15 iliac iliac NNP cord-028721-x6f26ahr 961 16 spine spine NN cord-028721-x6f26ahr 961 17 and and CC cord-028721-x6f26ahr 961 18 remains remain VBZ cord-028721-x6f26ahr 961 19 on on IN cord-028721-x6f26ahr 961 20 the the DT cord-028721-x6f26ahr 961 21 aponeurosis aponeurosis NN cord-028721-x6f26ahr 961 22 of of IN cord-028721-x6f26ahr 961 23 the the DT cord-028721-x6f26ahr 961 24 major major JJ cord-028721-x6f26ahr 961 25 oblique oblique JJ cord-028721-x6f26ahr 961 26 muscle muscle NN cord-028721-x6f26ahr 961 27 . . . cord-028721-x6f26ahr 962 1 These these DT cord-028721-x6f26ahr 962 2 testes testis NNS cord-028721-x6f26ahr 962 3 often often RB cord-028721-x6f26ahr 962 4 are be VBP cord-028721-x6f26ahr 962 5 more more RBR cord-028721-x6f26ahr 962 6 nearly nearly RB cord-028721-x6f26ahr 962 7 normal normal JJ cord-028721-x6f26ahr 962 8 histologically histologically RB cord-028721-x6f26ahr 962 9 than than IN cord-028721-x6f26ahr 962 10 are be VBP cord-028721-x6f26ahr 962 11 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 962 12 testes testis NNS cord-028721-x6f26ahr 962 13 . . . cord-028721-x6f26ahr 963 1 • • NNP cord-028721-x6f26ahr 964 1 Femoral femoral JJ cord-028721-x6f26ahr 964 2 or or CC cord-028721-x6f26ahr 964 3 crural crural JJ cord-028721-x6f26ahr 964 4 ectopia ectopia NN cord-028721-x6f26ahr 964 5 . . . cord-028721-x6f26ahr 965 1 After after IN cord-028721-x6f26ahr 965 2 passing pass VBG cord-028721-x6f26ahr 965 3 through through IN cord-028721-x6f26ahr 965 4 the the DT cord-028721-x6f26ahr 965 5 inguinal inguinal JJ cord-028721-x6f26ahr 965 6 canal canal NN cord-028721-x6f26ahr 965 7 , , , cord-028721-x6f26ahr 965 8 the the DT cord-028721-x6f26ahr 965 9 testis testis NN cord-028721-x6f26ahr 965 10 lodges lodge NNS cord-028721-x6f26ahr 965 11 in in IN cord-028721-x6f26ahr 965 12 the the DT cord-028721-x6f26ahr 965 13 high high JJ cord-028721-x6f26ahr 965 14 crural crural JJ cord-028721-x6f26ahr 965 15 cone cone NN cord-028721-x6f26ahr 965 16 in in IN cord-028721-x6f26ahr 965 17 Scarpa Scarpa NNP cord-028721-x6f26ahr 965 18 's 's POS cord-028721-x6f26ahr 965 19 triangle triangle NN cord-028721-x6f26ahr 965 20 . . . cord-028721-x6f26ahr 966 1 • • NNP cord-028721-x6f26ahr 967 1 Perineal Perineal NNP cord-028721-x6f26ahr 967 2 . . . cord-028721-x6f26ahr 968 1 The the DT cord-028721-x6f26ahr 968 2 testis testis NN cord-028721-x6f26ahr 968 3 is be VBZ cord-028721-x6f26ahr 968 4 located locate VBN cord-028721-x6f26ahr 968 5 between between IN cord-028721-x6f26ahr 968 6 the the DT cord-028721-x6f26ahr 968 7 raphe raphe NN cord-028721-x6f26ahr 968 8 and and CC cord-028721-x6f26ahr 968 9 the the DT cord-028721-x6f26ahr 968 10 genitocrural genitocrural NN cord-028721-x6f26ahr 968 11 fold fold NN cord-028721-x6f26ahr 968 12 . . . cord-028721-x6f26ahr 969 1 • • NNP cord-028721-x6f26ahr 970 1 Transverse transverse JJ cord-028721-x6f26ahr 970 2 or or CC cord-028721-x6f26ahr 970 3 crossed cross VBD cord-028721-x6f26ahr 970 4 ectopia ectopia NN cord-028721-x6f26ahr 970 5 . . . cord-028721-x6f26ahr 971 1 Both both DT cord-028721-x6f26ahr 971 2 testes testis NNS cord-028721-x6f26ahr 971 3 descend descend VBP cord-028721-x6f26ahr 971 4 through through IN cord-028721-x6f26ahr 971 5 the the DT cord-028721-x6f26ahr 971 6 same same JJ cord-028721-x6f26ahr 971 7 inguinal inguinal JJ cord-028721-x6f26ahr 971 8 canal canal NN cord-028721-x6f26ahr 971 9 and and CC cord-028721-x6f26ahr 971 10 lodge lodge VB cord-028721-x6f26ahr 971 11 in in IN cord-028721-x6f26ahr 971 12 the the DT cord-028721-x6f26ahr 971 13 same same JJ cord-028721-x6f26ahr 971 14 scrotal scrotal JJ cord-028721-x6f26ahr 971 15 pouch pouch NN cord-028721-x6f26ahr 971 16 . . . cord-028721-x6f26ahr 972 1 Each each DT cord-028721-x6f26ahr 972 2 possesses possess VBZ cord-028721-x6f26ahr 972 3 its -PRON- PRP$ cord-028721-x6f26ahr 972 4 own own JJ cord-028721-x6f26ahr 972 5 vascular vascular JJ cord-028721-x6f26ahr 972 6 supply supply NN cord-028721-x6f26ahr 972 7 , , , cord-028721-x6f26ahr 972 8 epididymis epididymis NN cord-028721-x6f26ahr 972 9 , , , cord-028721-x6f26ahr 972 10 and and CC cord-028721-x6f26ahr 972 11 vas vas NNP cord-028721-x6f26ahr 972 12 deferens deferen NNS cord-028721-x6f26ahr 972 13 . . . cord-028721-x6f26ahr 973 1 In in IN cord-028721-x6f26ahr 973 2 addition addition NN cord-028721-x6f26ahr 973 3 , , , cord-028721-x6f26ahr 973 4 there there EX cord-028721-x6f26ahr 973 5 is be VBZ cord-028721-x6f26ahr 973 6 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 973 7 hernia hernia NN cord-028721-x6f26ahr 973 8 . . . cord-028721-x6f26ahr 974 1 [ [ -LRB- cord-028721-x6f26ahr 974 2 423 423 CD cord-028721-x6f26ahr 974 3 ] ] -RRB- cord-028721-x6f26ahr 974 4 [ [ -LRB- cord-028721-x6f26ahr 974 5 424 424 CD cord-028721-x6f26ahr 974 6 ] ] -RRB- cord-028721-x6f26ahr 974 7 [ [ -LRB- cord-028721-x6f26ahr 974 8 425 425 CD cord-028721-x6f26ahr 974 9 ] ] -RRB- cord-028721-x6f26ahr 974 10 [ [ -LRB- cord-028721-x6f26ahr 974 11 426 426 CD cord-028721-x6f26ahr 974 12 ] ] -RRB- cord-028721-x6f26ahr 974 13 [ [ -LRB- cord-028721-x6f26ahr 974 14 427 427 CD cord-028721-x6f26ahr 974 15 ] ] -RRB- cord-028721-x6f26ahr 974 16 [ [ -LRB- cord-028721-x6f26ahr 974 17 428 428 CD cord-028721-x6f26ahr 974 18 ] ] -RRB- cord-028721-x6f26ahr 974 19 [ [ -LRB- cord-028721-x6f26ahr 974 20 429 429 CD cord-028721-x6f26ahr 974 21 ] ] -RRB- cord-028721-x6f26ahr 974 22 [ [ -LRB- cord-028721-x6f26ahr 974 23 430 430 CD cord-028721-x6f26ahr 974 24 ] ] -RRB- cord-028721-x6f26ahr 975 1 Between between IN cord-028721-x6f26ahr 975 2 20 20 CD cord-028721-x6f26ahr 975 3 % % NN cord-028721-x6f26ahr 975 4 and and CC cord-028721-x6f26ahr 975 5 40 40 CD cord-028721-x6f26ahr 975 6 % % NN cord-028721-x6f26ahr 975 7 of of IN cord-028721-x6f26ahr 975 8 patients patient NNS cord-028721-x6f26ahr 975 9 with with IN cord-028721-x6f26ahr 975 10 this this DT cord-028721-x6f26ahr 975 11 ectopia ectopia NN cord-028721-x6f26ahr 975 12 have have VBP cord-028721-x6f26ahr 975 13 persistent persistent JJ cord-028721-x6f26ahr 975 14 müllerian müllerian JJ cord-028721-x6f26ahr 975 15 duct duct NN cord-028721-x6f26ahr 975 16 syndrome syndrome NN cord-028721-x6f26ahr 975 17 [ [ -LRB- cord-028721-x6f26ahr 975 18 431 431 CD cord-028721-x6f26ahr 975 19 ] ] -RRB- cord-028721-x6f26ahr 975 20 [ [ -LRB- cord-028721-x6f26ahr 975 21 432 432 CD cord-028721-x6f26ahr 975 22 ] ] -RRB- cord-028721-x6f26ahr 975 23 and and CC cord-028721-x6f26ahr 975 24 show show VBP cord-028721-x6f26ahr 975 25 a a DT cord-028721-x6f26ahr 975 26 high high JJ cord-028721-x6f26ahr 975 27 incidence incidence NN cord-028721-x6f26ahr 975 28 of of IN cord-028721-x6f26ahr 975 29 testicular testicular JJ cord-028721-x6f26ahr 975 30 germ germ NN cord-028721-x6f26ahr 975 31 cell cell NN cord-028721-x6f26ahr 975 32 tumor tumor NN cord-028721-x6f26ahr 975 33 . . . cord-028721-x6f26ahr 976 1 433 433 CD cord-028721-x6f26ahr 976 2 • • NNS cord-028721-x6f26ahr 977 1 Pubopenile Pubopenile NNP cord-028721-x6f26ahr 977 2 ectopia ectopia NN cord-028721-x6f26ahr 977 3 . . . cord-028721-x6f26ahr 978 1 The the DT cord-028721-x6f26ahr 978 2 ectopic ectopic JJ cord-028721-x6f26ahr 978 3 testis testis NN cord-028721-x6f26ahr 978 4 is be VBZ cord-028721-x6f26ahr 978 5 on on IN cord-028721-x6f26ahr 978 6 the the DT cord-028721-x6f26ahr 978 7 back back NN cord-028721-x6f26ahr 978 8 of of IN cord-028721-x6f26ahr 978 9 the the DT cord-028721-x6f26ahr 978 10 penis penis NN cord-028721-x6f26ahr 978 11 near near IN cord-028721-x6f26ahr 978 12 the the DT cord-028721-x6f26ahr 978 13 symphysis symphysis NN cord-028721-x6f26ahr 978 14 pubis pubis NN cord-028721-x6f26ahr 978 15 . . . cord-028721-x6f26ahr 979 1 434 434 CD cord-028721-x6f26ahr 979 2 • • CD cord-028721-x6f26ahr 979 3 Pelvic Pelvic NNP cord-028721-x6f26ahr 979 4 ectopia ectopia NN cord-028721-x6f26ahr 979 5 . . . cord-028721-x6f26ahr 980 1 The the DT cord-028721-x6f26ahr 980 2 testis testis NN cord-028721-x6f26ahr 980 3 is be VBZ cord-028721-x6f26ahr 980 4 in in IN cord-028721-x6f26ahr 980 5 the the DT cord-028721-x6f26ahr 980 6 pelvis pelvi NNS cord-028721-x6f26ahr 980 7 , , , cord-028721-x6f26ahr 980 8 usually usually RB cord-028721-x6f26ahr 980 9 in in IN cord-028721-x6f26ahr 980 10 the the DT cord-028721-x6f26ahr 980 11 depth depth NN cord-028721-x6f26ahr 980 12 of of IN cord-028721-x6f26ahr 980 13 Douglas Douglas NNP cord-028721-x6f26ahr 980 14 ' ' POS cord-028721-x6f26ahr 980 15 cul cul NN cord-028721-x6f26ahr 980 16 - - HYPH cord-028721-x6f26ahr 980 17 de de JJ cord-028721-x6f26ahr 980 18 - - HYPH cord-028721-x6f26ahr 980 19 sac sac NN cord-028721-x6f26ahr 980 20 . . . cord-028721-x6f26ahr 981 1 • • NNP cord-028721-x6f26ahr 982 1 Other other JJ cord-028721-x6f26ahr 982 2 unusual unusual JJ cord-028721-x6f26ahr 982 3 testicular testicular NN cord-028721-x6f26ahr 982 4 ectopias ectopia NNS cord-028721-x6f26ahr 982 5 include include VBP cord-028721-x6f26ahr 982 6 retroumbilical retroumbilical JJ cord-028721-x6f26ahr 982 7 , , , cord-028721-x6f26ahr 982 8 craniolateral craniolateral JJ cord-028721-x6f26ahr 982 9 to to IN cord-028721-x6f26ahr 982 10 the the DT cord-028721-x6f26ahr 982 11 inner inner JJ cord-028721-x6f26ahr 982 12 inguinal inguinal JJ cord-028721-x6f26ahr 982 13 opening opening NN cord-028721-x6f26ahr 982 14 between between IN cord-028721-x6f26ahr 982 15 the the DT cord-028721-x6f26ahr 982 16 outer outer JJ cord-028721-x6f26ahr 982 17 and and CC cord-028721-x6f26ahr 982 18 inner inner JJ cord-028721-x6f26ahr 982 19 oblique oblique JJ cord-028721-x6f26ahr 982 20 muscles muscle NNS cord-028721-x6f26ahr 982 21 , , , cord-028721-x6f26ahr 982 22 and and CC cord-028721-x6f26ahr 982 23 subumbilical subumbilical NNP cord-028721-x6f26ahr 982 24 . . . cord-028721-x6f26ahr 983 1 435 435 CD cord-028721-x6f26ahr 984 1 Rarely rarely RB cord-028721-x6f26ahr 984 2 , , , cord-028721-x6f26ahr 984 3 the the DT cord-028721-x6f26ahr 984 4 testis testis NN cord-028721-x6f26ahr 984 5 and and CC cord-028721-x6f26ahr 984 6 its -PRON- PRP$ cord-028721-x6f26ahr 984 7 spermatic spermatic JJ cord-028721-x6f26ahr 984 8 cord cord NN cord-028721-x6f26ahr 984 9 may may MD cord-028721-x6f26ahr 984 10 protrude protrude VB cord-028721-x6f26ahr 984 11 through through IN cord-028721-x6f26ahr 984 12 a a DT cord-028721-x6f26ahr 984 13 defect defect NN cord-028721-x6f26ahr 984 14 in in IN cord-028721-x6f26ahr 984 15 the the DT cord-028721-x6f26ahr 984 16 scrotal scrotal JJ cord-028721-x6f26ahr 984 17 skin skin NN cord-028721-x6f26ahr 984 18 , , , cord-028721-x6f26ahr 984 19 a a DT cord-028721-x6f26ahr 984 20 condition condition NN cord-028721-x6f26ahr 984 21 called call VBN cord-028721-x6f26ahr 984 22 testicular testicular NNP cord-028721-x6f26ahr 984 23 exstrophy exstrophy NNP cord-028721-x6f26ahr 984 24 . . . cord-028721-x6f26ahr 985 1 436 436 CD cord-028721-x6f26ahr 986 1 The the DT cord-028721-x6f26ahr 986 2 term term NN cord-028721-x6f26ahr 986 3 testicular testicular JJ cord-028721-x6f26ahr 986 4 dislocation dislocation NN cord-028721-x6f26ahr 986 5 refers refer VBZ cord-028721-x6f26ahr 986 6 to to IN cord-028721-x6f26ahr 986 7 testes testis NNS cord-028721-x6f26ahr 986 8 that that WDT cord-028721-x6f26ahr 986 9 secondarily secondarily RB cord-028721-x6f26ahr 986 10 disappear disappear VBP cord-028721-x6f26ahr 986 11 from from IN cord-028721-x6f26ahr 986 12 the the DT cord-028721-x6f26ahr 986 13 scrotum scrotum NN cord-028721-x6f26ahr 986 14 and and CC cord-028721-x6f26ahr 986 15 lodge lodge VB cord-028721-x6f26ahr 986 16 around around IN cord-028721-x6f26ahr 986 17 the the DT cord-028721-x6f26ahr 986 18 superfi superfi NNS cord-028721-x6f26ahr 986 19 cial cial JJ cord-028721-x6f26ahr 986 20 inguinal inguinal JJ cord-028721-x6f26ahr 986 21 ring ring NN cord-028721-x6f26ahr 986 22 , , , cord-028721-x6f26ahr 986 23 within within IN cord-028721-x6f26ahr 986 24 the the DT cord-028721-x6f26ahr 986 25 inguinal inguinal JJ cord-028721-x6f26ahr 986 26 ring ring NN cord-028721-x6f26ahr 986 27 , , , cord-028721-x6f26ahr 986 28 or or CC cord-028721-x6f26ahr 986 29 inside inside IN cord-028721-x6f26ahr 986 30 the the DT cord-028721-x6f26ahr 986 31 abdominal abdominal JJ cord-028721-x6f26ahr 986 32 cavity cavity NN cord-028721-x6f26ahr 986 33 as as IN cord-028721-x6f26ahr 986 34 a a DT cord-028721-x6f26ahr 986 35 result result NN cord-028721-x6f26ahr 986 36 of of IN cord-028721-x6f26ahr 986 37 testicular testicular JJ cord-028721-x6f26ahr 986 38 trauma trauma NN cord-028721-x6f26ahr 986 39 . . . cord-028721-x6f26ahr 987 1 The the DT cord-028721-x6f26ahr 987 2 formation formation NN cord-028721-x6f26ahr 987 3 of of IN cord-028721-x6f26ahr 987 4 canalicular canalicular JJ cord-028721-x6f26ahr 987 5 and and CC cord-028721-x6f26ahr 987 6 intra intra JJ cord-028721-x6f26ahr 987 7 - - JJ cord-028721-x6f26ahr 987 8 abdominal abdominal JJ cord-028721-x6f26ahr 987 9 dislocation dislocation NN cord-028721-x6f26ahr 987 10 requires require VBZ cord-028721-x6f26ahr 987 11 the the DT cord-028721-x6f26ahr 987 12 presence presence NN cord-028721-x6f26ahr 987 13 of of IN cord-028721-x6f26ahr 987 14 previous previous JJ cord-028721-x6f26ahr 987 15 inguinal inguinal JJ cord-028721-x6f26ahr 987 16 hernia hernia NN cord-028721-x6f26ahr 987 17 . . . cord-028721-x6f26ahr 988 1 437 437 CD cord-028721-x6f26ahr 988 2 _SP cord-028721-x6f26ahr 989 1 Testicular testicular JJ cord-028721-x6f26ahr 989 2 fusion fusion NN cord-028721-x6f26ahr 989 3 is be VBZ cord-028721-x6f26ahr 989 4 a a DT cord-028721-x6f26ahr 989 5 rare rare JJ cord-028721-x6f26ahr 989 6 anomaly anomaly NN cord-028721-x6f26ahr 989 7 characterized characterize VBN cord-028721-x6f26ahr 989 8 by by IN cord-028721-x6f26ahr 989 9 fusion fusion NN cord-028721-x6f26ahr 989 10 of of IN cord-028721-x6f26ahr 989 11 the the DT cord-028721-x6f26ahr 989 12 testes testis NNS cord-028721-x6f26ahr 989 13 to to TO cord-028721-x6f26ahr 989 14 form form VB cord-028721-x6f26ahr 989 15 a a DT cord-028721-x6f26ahr 989 16 single single JJ cord-028721-x6f26ahr 989 17 structure structure NN cord-028721-x6f26ahr 989 18 , , , cord-028721-x6f26ahr 989 19 usually usually RB cord-028721-x6f26ahr 989 20 in in IN cord-028721-x6f26ahr 989 21 the the DT cord-028721-x6f26ahr 989 22 midline midline NN cord-028721-x6f26ahr 989 23 . . . cord-028721-x6f26ahr 990 1 Each each DT cord-028721-x6f26ahr 990 2 has have VBZ cord-028721-x6f26ahr 990 3 its -PRON- PRP$ cord-028721-x6f26ahr 990 4 own own JJ cord-028721-x6f26ahr 990 5 epididymis epididymis NN cord-028721-x6f26ahr 990 6 and and CC cord-028721-x6f26ahr 990 7 vas vas NNP cord-028721-x6f26ahr 990 8 deferens deferen NNS cord-028721-x6f26ahr 990 9 . . . cord-028721-x6f26ahr 991 1 This this DT cord-028721-x6f26ahr 991 2 anomaly anomaly NN cord-028721-x6f26ahr 991 3 is be VBZ cord-028721-x6f26ahr 991 4 often often RB cord-028721-x6f26ahr 991 5 associated associate VBN cord-028721-x6f26ahr 991 6 with with IN cord-028721-x6f26ahr 991 7 other other JJ cord-028721-x6f26ahr 991 8 malformations malformation NNS cord-028721-x6f26ahr 991 9 , , , cord-028721-x6f26ahr 991 10 such such JJ cord-028721-x6f26ahr 991 11 as as IN cord-028721-x6f26ahr 991 12 fusion fusion NN cord-028721-x6f26ahr 991 13 of of IN cord-028721-x6f26ahr 991 14 the the DT cord-028721-x6f26ahr 991 15 adrenal adrenal JJ cord-028721-x6f26ahr 991 16 glands gland NNS cord-028721-x6f26ahr 991 17 or or CC cord-028721-x6f26ahr 991 18 horseshoe horseshoe NN cord-028721-x6f26ahr 991 19 kidney kidney NN cord-028721-x6f26ahr 991 20 . . . cord-028721-x6f26ahr 992 1 Cystic cystic JJ cord-028721-x6f26ahr 992 2 dysplasia dysplasia NN cord-028721-x6f26ahr 992 3 of of IN cord-028721-x6f26ahr 992 4 the the DT cord-028721-x6f26ahr 992 5 testis testis NN cord-028721-x6f26ahr 992 6 is be VBZ cord-028721-x6f26ahr 992 7 a a DT cord-028721-x6f26ahr 992 8 congenital congenital JJ cord-028721-x6f26ahr 992 9 lesion lesion NN cord-028721-x6f26ahr 992 10 characterized characterize VBN cord-028721-x6f26ahr 992 11 by by IN cord-028721-x6f26ahr 992 12 cystic cystic JJ cord-028721-x6f26ahr 992 13 transformation transformation NN cord-028721-x6f26ahr 992 14 of of IN cord-028721-x6f26ahr 992 15 an an DT cord-028721-x6f26ahr 992 16 excessively excessively RB cord-028721-x6f26ahr 992 17 developed develop VBN cord-028721-x6f26ahr 992 18 rete rete NN cord-028721-x6f26ahr 992 19 testis testis NN cord-028721-x6f26ahr 992 20 that that WDT cord-028721-x6f26ahr 992 21 may may MD cord-028721-x6f26ahr 992 22 extend extend VB cord-028721-x6f26ahr 992 23 to to IN cord-028721-x6f26ahr 992 24 the the DT cord-028721-x6f26ahr 992 25 tunica tunica NNP cord-028721-x6f26ahr 992 26 albuginea albuginea NNP cord-028721-x6f26ahr 992 27 of of IN cord-028721-x6f26ahr 992 28 the the DT cord-028721-x6f26ahr 992 29 opposite opposite JJ cord-028721-x6f26ahr 992 30 pole pole NN cord-028721-x6f26ahr 992 31 . . . cord-028721-x6f26ahr 993 1 438 438 CD cord-028721-x6f26ahr 994 1 To to IN cord-028721-x6f26ahr 994 2 date date NN cord-028721-x6f26ahr 994 3 , , , cord-028721-x6f26ahr 994 4 fewer few JJR cord-028721-x6f26ahr 994 5 than than IN cord-028721-x6f26ahr 994 6 40 40 CD cord-028721-x6f26ahr 994 7 cases case NNS cord-028721-x6f26ahr 994 8 have have VBP cord-028721-x6f26ahr 994 9 been be VBN cord-028721-x6f26ahr 994 10 reported report VBN cord-028721-x6f26ahr 994 11 . . . cord-028721-x6f26ahr 995 1 439 439 CD cord-028721-x6f26ahr 995 2 , , , cord-028721-x6f26ahr 995 3 440 440 CD cord-028721-x6f26ahr 996 1 The the DT cord-028721-x6f26ahr 996 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 996 3 tubules tubule NNS cord-028721-x6f26ahr 996 4 may may MD cord-028721-x6f26ahr 996 5 be be VB cord-028721-x6f26ahr 996 6 dilated dilated JJ cord-028721-x6f26ahr 996 7 and and CC cord-028721-x6f26ahr 996 8 atrophic atrophic JJ cord-028721-x6f26ahr 996 9 ; ; : cord-028721-x6f26ahr 996 10 this this DT cord-028721-x6f26ahr 996 11 is be VBZ cord-028721-x6f26ahr 996 12 more more RBR cord-028721-x6f26ahr 996 13 evident evident JJ cord-028721-x6f26ahr 996 14 after after IN cord-028721-x6f26ahr 996 15 puberty puberty NN cord-028721-x6f26ahr 996 16 . . . cord-028721-x6f26ahr 997 1 Ultrasound ultrasound NN cord-028721-x6f26ahr 997 2 images image NNS cord-028721-x6f26ahr 997 3 are be VBP cord-028721-x6f26ahr 997 4 characteristic characteristic JJ cord-028721-x6f26ahr 997 5 . . . cord-028721-x6f26ahr 998 1 441 441 CD cord-028721-x6f26ahr 998 2 , , , cord-028721-x6f26ahr 998 3 442 442 CD cord-028721-x6f26ahr 998 4 Cysts cyst NNS cord-028721-x6f26ahr 998 5 arise arise VBP cord-028721-x6f26ahr 998 6 in in IN cord-028721-x6f26ahr 998 7 the the DT cord-028721-x6f26ahr 998 8 septal septal JJ cord-028721-x6f26ahr 998 9 and and CC cord-028721-x6f26ahr 998 10 mediastinal mediastinal JJ cord-028721-x6f26ahr 998 11 rete rete FW cord-028721-x6f26ahr 998 12 testis testis NN cord-028721-x6f26ahr 998 13 ( ( -LRB- cord-028721-x6f26ahr 998 14 Fig Fig NNP cord-028721-x6f26ahr 998 15 . . . cord-028721-x6f26ahr 998 16 12 12 CD cord-028721-x6f26ahr 998 17 -36 -36 NN cord-028721-x6f26ahr 998 18 ) ) -RRB- cord-028721-x6f26ahr 998 19 ; ; : cord-028721-x6f26ahr 998 20 they -PRON- PRP cord-028721-x6f26ahr 998 21 are be VBP cord-028721-x6f26ahr 998 22 interconnected interconnect VBN cord-028721-x6f26ahr 998 23 and and CC cord-028721-x6f26ahr 998 24 contain contain VBP cord-028721-x6f26ahr 998 25 acellular acellular JJ cord-028721-x6f26ahr 998 26 , , , cord-028721-x6f26ahr 998 27 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 998 28 , , , cord-028721-x6f26ahr 998 29 periodic periodic JJ cord-028721-x6f26ahr 998 30 acid acid NN cord-028721-x6f26ahr 998 31 - - HYPH cord-028721-x6f26ahr 998 32 Schiffpositive Schiffpositive NNP cord-028721-x6f26ahr 998 33 material material NN cord-028721-x6f26ahr 998 34 . . . cord-028721-x6f26ahr 999 1 They -PRON- PRP cord-028721-x6f26ahr 999 2 are be VBP cord-028721-x6f26ahr 999 3 lined line VBN cord-028721-x6f26ahr 999 4 by by IN cord-028721-x6f26ahr 999 5 cuboidal cuboidal JJ cord-028721-x6f26ahr 999 6 cells cell NNS cord-028721-x6f26ahr 999 7 that that WDT cord-028721-x6f26ahr 999 8 resemble resemble VBP cord-028721-x6f26ahr 999 9 those those DT cord-028721-x6f26ahr 999 10 of of IN cord-028721-x6f26ahr 999 11 the the DT cord-028721-x6f26ahr 999 12 normal normal JJ cord-028721-x6f26ahr 999 13 rete rete NN cord-028721-x6f26ahr 999 14 testis testis NN cord-028721-x6f26ahr 999 15 . . . cord-028721-x6f26ahr 1000 1 [ [ -LRB- cord-028721-x6f26ahr 1000 2 443 443 CD cord-028721-x6f26ahr 1000 3 ] ] -RRB- cord-028721-x6f26ahr 1000 4 [ [ -LRB- cord-028721-x6f26ahr 1000 5 444 444 CD cord-028721-x6f26ahr 1000 6 ] ] -RRB- cord-028721-x6f26ahr 1000 7 [ [ -LRB- cord-028721-x6f26ahr 1000 8 445 445 CD cord-028721-x6f26ahr 1000 9 ] ] -RRB- cord-028721-x6f26ahr 1001 1 The the DT cord-028721-x6f26ahr 1001 2 connective connective JJ cord-028721-x6f26ahr 1001 3 tissue tissue NN cord-028721-x6f26ahr 1001 4 between between IN cord-028721-x6f26ahr 1001 5 the the DT cord-028721-x6f26ahr 1001 6 cysts cyst NNS cord-028721-x6f26ahr 1001 7 is be VBZ cord-028721-x6f26ahr 1001 8 scant scant JJ cord-028721-x6f26ahr 1001 9 and and CC cord-028721-x6f26ahr 1001 10 histologically histologically RB cord-028721-x6f26ahr 1001 11 similar similar JJ cord-028721-x6f26ahr 1001 12 to to IN cord-028721-x6f26ahr 1001 13 the the DT cord-028721-x6f26ahr 1001 14 interstitial interstitial JJ cord-028721-x6f26ahr 1001 15 connective connective JJ cord-028721-x6f26ahr 1001 16 tissue tissue NN cord-028721-x6f26ahr 1001 17 . . . cord-028721-x6f26ahr 1002 1 There there EX cord-028721-x6f26ahr 1002 2 may may MD cord-028721-x6f26ahr 1002 3 be be VB cord-028721-x6f26ahr 1002 4 small small JJ cord-028721-x6f26ahr 1002 5 groups group NNS cord-028721-x6f26ahr 1002 6 of of IN cord-028721-x6f26ahr 1002 7 cysts cyst NNS cord-028721-x6f26ahr 1002 8 limited limit VBN cord-028721-x6f26ahr 1002 9 to to IN cord-028721-x6f26ahr 1002 10 the the DT cord-028721-x6f26ahr 1002 11 region region NN cord-028721-x6f26ahr 1002 12 of of IN cord-028721-x6f26ahr 1002 13 the the DT cord-028721-x6f26ahr 1002 14 mediastinum mediastinum NNP cord-028721-x6f26ahr 1002 15 testis testis NN cord-028721-x6f26ahr 1002 16 , , , cord-028721-x6f26ahr 1002 17 or or CC cord-028721-x6f26ahr 1002 18 cysts cyst NNS cord-028721-x6f26ahr 1002 19 extending extend VBG cord-028721-x6f26ahr 1002 20 throughout throughout IN cord-028721-x6f26ahr 1002 21 the the DT cord-028721-x6f26ahr 1002 22 entire entire JJ cord-028721-x6f26ahr 1002 23 testis testis NN cord-028721-x6f26ahr 1002 24 . . . cord-028721-x6f26ahr 1003 1 In in IN cord-028721-x6f26ahr 1003 2 extensive extensive JJ cord-028721-x6f26ahr 1003 3 cases case NNS cord-028721-x6f26ahr 1003 4 , , , cord-028721-x6f26ahr 1003 5 residual residual JJ cord-028721-x6f26ahr 1003 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 1003 7 tubules tubule NNS cord-028721-x6f26ahr 1003 8 occupy occupy VBP cord-028721-x6f26ahr 1003 9 only only RB cord-028721-x6f26ahr 1003 10 a a DT cord-028721-x6f26ahr 1003 11 small small JJ cord-028721-x6f26ahr 1003 12 crescent crescent NN cord-028721-x6f26ahr 1003 13 beneath beneath IN cord-028721-x6f26ahr 1003 14 the the DT cord-028721-x6f26ahr 1003 15 tunica tunica NNP cord-028721-x6f26ahr 1003 16 albuginea albuginea NNP cord-028721-x6f26ahr 1003 17 and and CC cord-028721-x6f26ahr 1003 18 the the DT cord-028721-x6f26ahr 1003 19 testis testis NN cord-028721-x6f26ahr 1003 20 is be VBZ cord-028721-x6f26ahr 1003 21 grossly grossly RB cord-028721-x6f26ahr 1003 22 spongy spongy JJ cord-028721-x6f26ahr 1003 23 . . . cord-028721-x6f26ahr 1004 1 Cystic cystic JJ cord-028721-x6f26ahr 1004 2 dysplasia dysplasia NN cord-028721-x6f26ahr 1004 3 occurs occur VBZ cord-028721-x6f26ahr 1004 4 in in IN cord-028721-x6f26ahr 1004 5 normally normally RB cord-028721-x6f26ahr 1004 6 descended descend VBN cord-028721-x6f26ahr 1004 7 and and CC cord-028721-x6f26ahr 1004 8 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1004 9 testes testis NNS cord-028721-x6f26ahr 1004 10 in in IN cord-028721-x6f26ahr 1004 11 children child NNS cord-028721-x6f26ahr 1004 12 and and CC cord-028721-x6f26ahr 1004 13 adults adult NNS cord-028721-x6f26ahr 1004 14 , , , cord-028721-x6f26ahr 1004 15 and and CC cord-028721-x6f26ahr 1004 16 may may MD cord-028721-x6f26ahr 1004 17 affect affect VB cord-028721-x6f26ahr 1004 18 one one CD cord-028721-x6f26ahr 1004 19 or or CC cord-028721-x6f26ahr 1004 20 both both DT cord-028721-x6f26ahr 1004 21 testes testis NNS cord-028721-x6f26ahr 1004 22 . . . cord-028721-x6f26ahr 1005 1 446 446 CD cord-028721-x6f26ahr 1006 1 In in IN cord-028721-x6f26ahr 1006 2 adults adult NNS cord-028721-x6f26ahr 1006 3 , , , cord-028721-x6f26ahr 1006 4 the the DT cord-028721-x6f26ahr 1006 5 residual residual JJ cord-028721-x6f26ahr 1006 6 parenchyma parenchyma NN cord-028721-x6f26ahr 1006 7 often often RB cord-028721-x6f26ahr 1006 8 shows show VBZ cord-028721-x6f26ahr 1006 9 complete complete JJ cord-028721-x6f26ahr 1006 10 tubular tubular JJ cord-028721-x6f26ahr 1006 11 sclerosis sclerosis NN cord-028721-x6f26ahr 1006 12 or or CC cord-028721-x6f26ahr 1006 13 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 1006 14 with with IN cord-028721-x6f26ahr 1006 15 intratubular intratubular NNP cord-028721-x6f26ahr 1006 16 accumulation accumulation NN cord-028721-x6f26ahr 1006 17 of of IN cord-028721-x6f26ahr 1006 18 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 1006 19 and and CC cord-028721-x6f26ahr 1006 20 Leydig Leydig NNP cord-028721-x6f26ahr 1006 21 cell cell NN cord-028721-x6f26ahr 1006 22 pseudohyperplasia pseudohyperplasia NNS cord-028721-x6f26ahr 1006 23 . . . cord-028721-x6f26ahr 1007 1 In in IN cord-028721-x6f26ahr 1007 2 most most JJS cord-028721-x6f26ahr 1007 3 cases case NNS cord-028721-x6f26ahr 1007 4 the the DT cord-028721-x6f26ahr 1007 5 epididymis epididymis NN cord-028721-x6f26ahr 1007 6 is be VBZ cord-028721-x6f26ahr 1007 7 altered alter VBN cord-028721-x6f26ahr 1007 8 . . . cord-028721-x6f26ahr 1008 1 447 447 CD cord-028721-x6f26ahr 1009 1 The the DT cord-028721-x6f26ahr 1009 2 head head NN cord-028721-x6f26ahr 1009 3 of of IN cord-028721-x6f26ahr 1009 4 the the DT cord-028721-x6f26ahr 1009 5 epididymis epididymis NN cord-028721-x6f26ahr 1009 6 is be VBZ cord-028721-x6f26ahr 1009 7 small small JJ cord-028721-x6f26ahr 1009 8 and and CC cord-028721-x6f26ahr 1009 9 contains contain VBZ cord-028721-x6f26ahr 1009 10 few few JJ cord-028721-x6f26ahr 1009 11 ductuli ductuli NNP cord-028721-x6f26ahr 1009 12 efferentes efferente NNS cord-028721-x6f26ahr 1009 13 with with IN cord-028721-x6f26ahr 1009 14 irregular irregular JJ cord-028721-x6f26ahr 1009 15 , , , cord-028721-x6f26ahr 1009 16 usually usually RB cord-028721-x6f26ahr 1009 17 dilated dilated JJ cord-028721-x6f26ahr 1009 18 lumina lumina NNP cord-028721-x6f26ahr 1009 19 . . . cord-028721-x6f26ahr 1010 1 The the DT cord-028721-x6f26ahr 1010 2 ductus ductus NN cord-028721-x6f26ahr 1010 3 epididymidis epididymidis NN cord-028721-x6f26ahr 1010 4 is be VBZ cord-028721-x6f26ahr 1010 5 dilated dilate VBN cord-028721-x6f26ahr 1010 6 , , , cord-028721-x6f26ahr 1010 7 has have VBZ cord-028721-x6f26ahr 1010 8 an an DT cord-028721-x6f26ahr 1010 9 atrophic atrophic JJ cord-028721-x6f26ahr 1010 10 epithelium epithelium NN cord-028721-x6f26ahr 1010 11 , , , cord-028721-x6f26ahr 1010 12 and and CC cord-028721-x6f26ahr 1010 13 thick thick JJ cord-028721-x6f26ahr 1010 14 connective connective JJ cord-028721-x6f26ahr 1010 15 tissue tissue NN cord-028721-x6f26ahr 1010 16 replaces replace VBZ cord-028721-x6f26ahr 1010 17 the the DT cord-028721-x6f26ahr 1010 18 muscular muscular JJ cord-028721-x6f26ahr 1010 19 layer layer NN cord-028721-x6f26ahr 1010 20 ( ( -LRB- cord-028721-x6f26ahr 1010 21 Fig Fig NNP cord-028721-x6f26ahr 1010 22 . . . cord-028721-x6f26ahr 1010 23 12 12 CD cord-028721-x6f26ahr 1010 24 - - SYM cord-028721-x6f26ahr 1010 25 37 37 CD cord-028721-x6f26ahr 1010 26 ) ) -RRB- cord-028721-x6f26ahr 1010 27 . . . cord-028721-x6f26ahr 1011 1 Testicular testicular JJ cord-028721-x6f26ahr 1011 2 cystic cystic JJ cord-028721-x6f26ahr 1011 3 dysplasia dysplasia NN cord-028721-x6f26ahr 1011 4 is be VBZ cord-028721-x6f26ahr 1011 5 frequently frequently RB cord-028721-x6f26ahr 1011 6 associated associate VBN cord-028721-x6f26ahr 1011 7 with with IN cord-028721-x6f26ahr 1011 8 severe severe JJ cord-028721-x6f26ahr 1011 9 anomalies anomaly NNS cord-028721-x6f26ahr 1011 10 of of IN cord-028721-x6f26ahr 1011 11 the the DT cord-028721-x6f26ahr 1011 12 urinary urinary JJ cord-028721-x6f26ahr 1011 13 system system NN cord-028721-x6f26ahr 1011 14 . . . cord-028721-x6f26ahr 1012 1 Renal renal JJ cord-028721-x6f26ahr 1012 2 agenesis agenesis NN cord-028721-x6f26ahr 1012 3 , , , cord-028721-x6f26ahr 1012 4 [ [ -LRB- cord-028721-x6f26ahr 1012 5 446 446 CD cord-028721-x6f26ahr 1012 6 ] ] -RRB- cord-028721-x6f26ahr 1012 7 [ [ -LRB- cord-028721-x6f26ahr 1012 8 447 447 CD cord-028721-x6f26ahr 1012 9 ] ] -RRB- cord-028721-x6f26ahr 1012 10 [ [ -LRB- cord-028721-x6f26ahr 1012 11 448 448 CD cord-028721-x6f26ahr 1012 12 ] ] -RRB- cord-028721-x6f26ahr 1012 13 [ [ -LRB- cord-028721-x6f26ahr 1012 14 449 449 CD cord-028721-x6f26ahr 1012 15 ] ] -RRB- cord-028721-x6f26ahr 1012 16 renal renal JJ cord-028721-x6f26ahr 1012 17 dysplasia dysplasia NN cord-028721-x6f26ahr 1012 18 , , , cord-028721-x6f26ahr 1012 19 446 446 CD cord-028721-x6f26ahr 1012 20 hydroureter hydroureter NN cord-028721-x6f26ahr 1012 21 , , , cord-028721-x6f26ahr 1012 22 and and CC cord-028721-x6f26ahr 1012 23 urethral urethral JJ cord-028721-x6f26ahr 1012 24 stenosis stenosis NN cord-028721-x6f26ahr 1012 25 450 450 CD cord-028721-x6f26ahr 1012 26 have have VBP cord-028721-x6f26ahr 1012 27 been be VBN cord-028721-x6f26ahr 1012 28 reported report VBN cord-028721-x6f26ahr 1012 29 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 1012 30 to to IN cord-028721-x6f26ahr 1012 31 cystic cystic JJ cord-028721-x6f26ahr 1012 32 dysplasia dysplasia NN cord-028721-x6f26ahr 1012 33 . . . cord-028721-x6f26ahr 1013 1 The the DT cord-028721-x6f26ahr 1013 2 clinical clinical JJ cord-028721-x6f26ahr 1013 3 differential differential NN cord-028721-x6f26ahr 1013 4 diagnosis diagnosis NN cord-028721-x6f26ahr 1013 5 should should MD cord-028721-x6f26ahr 1013 6 consider consider VB cord-028721-x6f26ahr 1013 7 all all DT cord-028721-x6f26ahr 1013 8 cystic cystic JJ cord-028721-x6f26ahr 1013 9 testicular testicular JJ cord-028721-x6f26ahr 1013 10 lesions lesion NNS cord-028721-x6f26ahr 1013 11 impairing impair VBG cord-028721-x6f26ahr 1013 12 prepubertal prepubertal JJ cord-028721-x6f26ahr 1013 13 testes testis NNS cord-028721-x6f26ahr 1013 14 , , , cord-028721-x6f26ahr 1013 15 including include VBG cord-028721-x6f26ahr 1013 16 epidermoid epidermoid JJ cord-028721-x6f26ahr 1013 17 cyst cyst NN cord-028721-x6f26ahr 1013 18 , , , cord-028721-x6f26ahr 1013 19 cystic cystic JJ cord-028721-x6f26ahr 1013 20 teratoma teratoma NN cord-028721-x6f26ahr 1013 21 , , , cord-028721-x6f26ahr 1013 22 juvenile juvenile JJ cord-028721-x6f26ahr 1013 23 granulosa granulosa JJ cord-028721-x6f26ahr 1013 24 cell cell NN cord-028721-x6f26ahr 1013 25 tumor tumor NN cord-028721-x6f26ahr 1013 26 , , , cord-028721-x6f26ahr 1013 27 testicular testicular NNP cord-028721-x6f26ahr 1013 28 lymphangiectasis lymphangiectasis NNP cord-028721-x6f26ahr 1013 29 , , , cord-028721-x6f26ahr 1013 30 and and CC cord-028721-x6f26ahr 1013 31 simple simple JJ cord-028721-x6f26ahr 1013 32 cyst cyst NN cord-028721-x6f26ahr 1013 33 of of IN cord-028721-x6f26ahr 1013 34 the the DT cord-028721-x6f26ahr 1013 35 testis testis NN cord-028721-x6f26ahr 1013 36 . . . cord-028721-x6f26ahr 1014 1 451 451 CD cord-028721-x6f26ahr 1015 1 The the DT cord-028721-x6f26ahr 1015 2 presence presence NN cord-028721-x6f26ahr 1015 3 of of IN cord-028721-x6f26ahr 1015 4 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 1015 5 renal renal JJ cord-028721-x6f26ahr 1015 6 anomalies anomaly NNS cord-028721-x6f26ahr 1015 7 during during IN cord-028721-x6f26ahr 1015 8 ultrasound ultrasound NN cord-028721-x6f26ahr 1015 9 exploration exploration NN cord-028721-x6f26ahr 1015 10 provides provide VBZ cord-028721-x6f26ahr 1015 11 an an DT cord-028721-x6f26ahr 1015 12 important important JJ cord-028721-x6f26ahr 1015 13 diagnostic diagnostic JJ cord-028721-x6f26ahr 1015 14 clue clue NN cord-028721-x6f26ahr 1015 15 . . . cord-028721-x6f26ahr 1016 1 452 452 CD cord-028721-x6f26ahr 1017 1 Previously previously RB cord-028721-x6f26ahr 1017 2 , , , cord-028721-x6f26ahr 1017 3 orchidectomy orchidectomy NN cord-028721-x6f26ahr 1017 4 was be VBD cord-028721-x6f26ahr 1017 5 the the DT cord-028721-x6f26ahr 1017 6 treatment treatment NN cord-028721-x6f26ahr 1017 7 of of IN cord-028721-x6f26ahr 1017 8 choice choice NN cord-028721-x6f26ahr 1017 9 , , , cord-028721-x6f26ahr 1017 10 but but CC cord-028721-x6f26ahr 1017 11 testis testis NN cord-028721-x6f26ahr 1017 12 - - HYPH cord-028721-x6f26ahr 1017 13 sparing spare VBG cord-028721-x6f26ahr 1017 14 surgery surgery NN cord-028721-x6f26ahr 1017 15 453 453 CD cord-028721-x6f26ahr 1017 16 is be VBZ cord-028721-x6f26ahr 1017 17 now now RB cord-028721-x6f26ahr 1017 18 recommended recommend VBN cord-028721-x6f26ahr 1017 19 . . . cord-028721-x6f26ahr 1018 1 454 454 CD cord-028721-x6f26ahr 1018 2 , , , cord-028721-x6f26ahr 1018 3 455 455 CD cord-028721-x6f26ahr 1019 1 The the DT cord-028721-x6f26ahr 1019 2 etiology etiology NN cord-028721-x6f26ahr 1019 3 and and CC cord-028721-x6f26ahr 1019 4 pathogenesis pathogenesis NN cord-028721-x6f26ahr 1019 5 of of IN cord-028721-x6f26ahr 1019 6 cystic cystic JJ cord-028721-x6f26ahr 1019 7 dysplasia dysplasia NN cord-028721-x6f26ahr 1019 8 are be VBP cord-028721-x6f26ahr 1019 9 uncertain uncertain JJ cord-028721-x6f26ahr 1019 10 . . . cord-028721-x6f26ahr 1020 1 Given give VBN cord-028721-x6f26ahr 1020 2 that that IN cord-028721-x6f26ahr 1020 3 the the DT cord-028721-x6f26ahr 1020 4 rete rete NN cord-028721-x6f26ahr 1020 5 testis testis NN cord-028721-x6f26ahr 1020 6 is be VBZ cord-028721-x6f26ahr 1020 7 a a DT cord-028721-x6f26ahr 1020 8 mesonephric mesonephric JJ cord-028721-x6f26ahr 1020 9 derivative derivative JJ cord-028721-x6f26ahr 1020 10 and and CC cord-028721-x6f26ahr 1020 11 most most JJS cord-028721-x6f26ahr 1020 12 of of IN cord-028721-x6f26ahr 1020 13 the the DT cord-028721-x6f26ahr 1020 14 associated associate VBN cord-028721-x6f26ahr 1020 15 renal renal JJ cord-028721-x6f26ahr 1020 16 malformations malformation NNS cord-028721-x6f26ahr 1020 17 are be VBP cord-028721-x6f26ahr 1020 18 apparently apparently RB cord-028721-x6f26ahr 1020 19 caused cause VBN cord-028721-x6f26ahr 1020 20 by by IN cord-028721-x6f26ahr 1020 21 failure failure NN cord-028721-x6f26ahr 1020 22 in in IN cord-028721-x6f26ahr 1020 23 the the DT cord-028721-x6f26ahr 1020 24 induction induction NN cord-028721-x6f26ahr 1020 25 of of IN cord-028721-x6f26ahr 1020 26 renal renal JJ cord-028721-x6f26ahr 1020 27 blastema blastema NN cord-028721-x6f26ahr 1020 28 by by IN cord-028721-x6f26ahr 1020 29 the the DT cord-028721-x6f26ahr 1020 30 mesonephros mesonephros NNP cord-028721-x6f26ahr 1020 31 , , , cord-028721-x6f26ahr 1020 32 cystic cystic JJ cord-028721-x6f26ahr 1020 33 dysplasia dysplasia NN cord-028721-x6f26ahr 1020 34 is be VBZ cord-028721-x6f26ahr 1020 35 considered consider VBN cord-028721-x6f26ahr 1020 36 to to TO cord-028721-x6f26ahr 1020 37 be be VB cord-028721-x6f26ahr 1020 38 the the DT cord-028721-x6f26ahr 1020 39 result result NN cord-028721-x6f26ahr 1020 40 of of IN cord-028721-x6f26ahr 1020 41 an an DT cord-028721-x6f26ahr 1020 42 abnormal abnormal JJ cord-028721-x6f26ahr 1020 43 mesonephros mesonephro NNS cord-028721-x6f26ahr 1020 44 . . . cord-028721-x6f26ahr 1021 1 During during IN cord-028721-x6f26ahr 1021 2 childhood childhood NN cord-028721-x6f26ahr 1021 3 , , , cord-028721-x6f26ahr 1021 4 the the DT cord-028721-x6f26ahr 1021 5 normal normal JJ cord-028721-x6f26ahr 1021 6 rete rete NN cord-028721-x6f26ahr 1021 7 testis testis NN cord-028721-x6f26ahr 1021 8 has have VBZ cord-028721-x6f26ahr 1021 9 no no DT cord-028721-x6f26ahr 1021 10 lumina lumina NN cord-028721-x6f26ahr 1021 11 , , , cord-028721-x6f26ahr 1021 12 and and CC cord-028721-x6f26ahr 1021 13 these these DT cord-028721-x6f26ahr 1021 14 form form NN cord-028721-x6f26ahr 1021 15 during during IN cord-028721-x6f26ahr 1021 16 puberty puberty NN cord-028721-x6f26ahr 1021 17 . . . cord-028721-x6f26ahr 1022 1 The the DT cord-028721-x6f26ahr 1022 2 adult adult NN cord-028721-x6f26ahr 1022 3 rete rete NN cord-028721-x6f26ahr 1022 4 testis testis NN cord-028721-x6f26ahr 1022 5 is be VBZ cord-028721-x6f26ahr 1022 6 a a DT cord-028721-x6f26ahr 1022 7 conduit conduit NN cord-028721-x6f26ahr 1022 8 for for IN cord-028721-x6f26ahr 1022 9 the the DT cord-028721-x6f26ahr 1022 10 passage passage NN cord-028721-x6f26ahr 1022 11 of of IN cord-028721-x6f26ahr 1022 12 tubular tubular JJ cord-028721-x6f26ahr 1022 13 fl fl NNP cord-028721-x6f26ahr 1022 14 uid uid NNS cord-028721-x6f26ahr 1022 15 and and CC cord-028721-x6f26ahr 1022 16 spermatozoa spermatozoa NN cord-028721-x6f26ahr 1022 17 and and CC cord-028721-x6f26ahr 1022 18 also also RB cord-028721-x6f26ahr 1022 19 actively actively RB cord-028721-x6f26ahr 1022 20 reabsorbs reabsorb VBZ cord-028721-x6f26ahr 1022 21 part part NN cord-028721-x6f26ahr 1022 22 of of IN cord-028721-x6f26ahr 1022 23 this this DT cord-028721-x6f26ahr 1022 24 fl fl NNP cord-028721-x6f26ahr 1022 25 uid uid NN cord-028721-x6f26ahr 1022 26 while while IN cord-028721-x6f26ahr 1022 27 adding add VBG cord-028721-x6f26ahr 1022 28 ions ion NNS cord-028721-x6f26ahr 1022 29 , , , cord-028721-x6f26ahr 1022 30 proteins protein NNS cord-028721-x6f26ahr 1022 31 and and CC cord-028721-x6f26ahr 1022 32 steroids steroid NNS cord-028721-x6f26ahr 1022 33 to to IN cord-028721-x6f26ahr 1022 34 it -PRON- PRP cord-028721-x6f26ahr 1022 35 . . . cord-028721-x6f26ahr 1023 1 Malfunction malfunction NN cord-028721-x6f26ahr 1023 2 of of IN cord-028721-x6f26ahr 1023 3 the the DT cord-028721-x6f26ahr 1023 4 rete rete NN cord-028721-x6f26ahr 1023 5 testis testis NN cord-028721-x6f26ahr 1023 6 cells cell NNS cord-028721-x6f26ahr 1023 7 may may MD cord-028721-x6f26ahr 1023 8 cause cause VB cord-028721-x6f26ahr 1023 9 the the DT cord-028721-x6f26ahr 1023 10 formation formation NN cord-028721-x6f26ahr 1023 11 of of IN cord-028721-x6f26ahr 1023 12 excessive excessive JJ cord-028721-x6f26ahr 1023 13 fl fl JJ cord-028721-x6f26ahr 1023 14 uid uid NN cord-028721-x6f26ahr 1023 15 of of IN cord-028721-x6f26ahr 1023 16 abnormal abnormal JJ cord-028721-x6f26ahr 1023 17 composition composition NN cord-028721-x6f26ahr 1023 18 , , , cord-028721-x6f26ahr 1023 19 resulting result VBG cord-028721-x6f26ahr 1023 20 in in IN cord-028721-x6f26ahr 1023 21 a a DT cord-028721-x6f26ahr 1023 22 condition condition NN cord-028721-x6f26ahr 1023 23 morphologically morphologically RB cord-028721-x6f26ahr 1023 24 similar similar JJ cord-028721-x6f26ahr 1023 25 to to IN cord-028721-x6f26ahr 1023 26 cystic cystic JJ cord-028721-x6f26ahr 1023 27 dysplasia dysplasia NN cord-028721-x6f26ahr 1023 28 of of IN cord-028721-x6f26ahr 1023 29 the the DT cord-028721-x6f26ahr 1023 30 rete rete NN cord-028721-x6f26ahr 1023 31 testis testis NN cord-028721-x6f26ahr 1023 32 induced induce VBN cord-028721-x6f26ahr 1023 33 in in IN cord-028721-x6f26ahr 1023 34 fowl fowl NN cord-028721-x6f26ahr 1023 35 by by IN cord-028721-x6f26ahr 1023 36 sodium sodium NN cord-028721-x6f26ahr 1023 37 intoxication intoxication NN cord-028721-x6f26ahr 1023 38 or or CC cord-028721-x6f26ahr 1023 39 the the DT cord-028721-x6f26ahr 1023 40 administration administration NN cord-028721-x6f26ahr 1023 41 of of IN cord-028721-x6f26ahr 1023 42 the the DT cord-028721-x6f26ahr 1023 43 saltretaining saltretaine VBG cord-028721-x6f26ahr 1023 44 hormone hormone NN cord-028721-x6f26ahr 1023 45 deoxycorticosterone deoxycorticosterone NNP cord-028721-x6f26ahr 1023 46 acetate acetate NNP cord-028721-x6f26ahr 1023 47 . . . cord-028721-x6f26ahr 1024 1 Gonadoblastoid gonadoblastoid JJ cord-028721-x6f26ahr 1024 2 testicular testicular JJ cord-028721-x6f26ahr 1024 3 dysplasia dysplasia NN cord-028721-x6f26ahr 1024 4 refers refer VBZ cord-028721-x6f26ahr 1024 5 to to IN cord-028721-x6f26ahr 1024 6 an an DT cord-028721-x6f26ahr 1024 7 abnormally abnormally RB cord-028721-x6f26ahr 1024 8 differentiated differentiate VBN cord-028721-x6f26ahr 1024 9 testicular testicular JJ cord-028721-x6f26ahr 1024 10 parenchyma parenchyma NN cord-028721-x6f26ahr 1024 11 beneath beneath IN cord-028721-x6f26ahr 1024 12 the the DT cord-028721-x6f26ahr 1024 13 tunica tunica NNP cord-028721-x6f26ahr 1024 14 albuginea albuginea NNP cord-028721-x6f26ahr 1024 15 . . . cord-028721-x6f26ahr 1025 1 456 456 CD cord-028721-x6f26ahr 1026 1 The the DT cord-028721-x6f26ahr 1026 2 anomaly anomaly NN cord-028721-x6f26ahr 1026 3 consists consist VBZ cord-028721-x6f26ahr 1026 4 of of IN cord-028721-x6f26ahr 1026 5 large large JJ cord-028721-x6f26ahr 1026 6 tubular tubular JJ cord-028721-x6f26ahr 1026 7 or or CC cord-028721-x6f26ahr 1026 8 nodular nodular JJ cord-028721-x6f26ahr 1026 9 structures structure NNS cord-028721-x6f26ahr 1026 10 within within IN cord-028721-x6f26ahr 1026 11 a a DT cord-028721-x6f26ahr 1026 12 dense dense JJ cord-028721-x6f26ahr 1026 13 stroma stroma NN cord-028721-x6f26ahr 1026 14 , , , cord-028721-x6f26ahr 1026 15 reminiscent reminiscent JJ cord-028721-x6f26ahr 1026 16 of of IN cord-028721-x6f26ahr 1026 17 ovarian ovarian JJ cord-028721-x6f26ahr 1026 18 stroma stroma NN cord-028721-x6f26ahr 1026 19 ( ( -LRB- cord-028721-x6f26ahr 1026 20 Fig Fig NNP cord-028721-x6f26ahr 1026 21 . . . cord-028721-x6f26ahr 1026 22 12 12 CD cord-028721-x6f26ahr 1026 23 - - SYM cord-028721-x6f26ahr 1026 24 38 38 CD cord-028721-x6f26ahr 1026 25 ) ) -RRB- cord-028721-x6f26ahr 1026 26 . . . cord-028721-x6f26ahr 1027 1 Each each DT cord-028721-x6f26ahr 1027 2 structure structure NN cord-028721-x6f26ahr 1027 3 is be VBZ cord-028721-x6f26ahr 1027 4 composed compose VBN cord-028721-x6f26ahr 1027 5 of of IN cord-028721-x6f26ahr 1027 6 three three CD cord-028721-x6f26ahr 1027 7 cell cell NN cord-028721-x6f26ahr 1027 8 types type NNS cord-028721-x6f26ahr 1027 9 : : : cord-028721-x6f26ahr 1027 10 cells cell NNS cord-028721-x6f26ahr 1027 11 with with IN cord-028721-x6f26ahr 1027 12 vesicular vesicular JJ cord-028721-x6f26ahr 1027 13 nuclei nucleus NNS cord-028721-x6f26ahr 1027 14 and and CC cord-028721-x6f26ahr 1027 15 vacuolated vacuolate VBN cord-028721-x6f26ahr 1027 16 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1027 17 ; ; : cord-028721-x6f26ahr 1027 18 cells cell NNS cord-028721-x6f26ahr 1027 19 with with IN cord-028721-x6f26ahr 1027 20 hyperchromatic hyperchromatic JJ cord-028721-x6f26ahr 1027 21 nuclei nucleus NNS cord-028721-x6f26ahr 1027 22 ; ; : cord-028721-x6f26ahr 1027 23 and and CC cord-028721-x6f26ahr 1027 24 germ germ NN cord-028721-x6f26ahr 1027 25 cell cell NN cord-028721-x6f26ahr 1027 26 - - HYPH cord-028721-x6f26ahr 1027 27 like like JJ cord-028721-x6f26ahr 1027 28 cells cell NNS cord-028721-x6f26ahr 1027 29 . . . cord-028721-x6f26ahr 1028 1 The the DT cord-028721-x6f26ahr 1028 2 former former JJ cord-028721-x6f26ahr 1028 3 two two CD cord-028721-x6f26ahr 1028 4 types type NNS cord-028721-x6f26ahr 1028 5 are be VBP cord-028721-x6f26ahr 1028 6 arranged arrange VBN cord-028721-x6f26ahr 1028 7 at at IN cord-028721-x6f26ahr 1028 8 the the DT cord-028721-x6f26ahr 1028 9 periphery periphery NN cord-028721-x6f26ahr 1028 10 , , , cord-028721-x6f26ahr 1028 11 forming form VBG cord-028721-x6f26ahr 1028 12 a a DT cord-028721-x6f26ahr 1028 13 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 1028 14 ed ed NN cord-028721-x6f26ahr 1028 15 epithelium epithelium NN cord-028721-x6f26ahr 1028 16 . . . cord-028721-x6f26ahr 1029 1 The the DT cord-028721-x6f26ahr 1029 2 third third JJ cord-028721-x6f26ahr 1029 3 type type NN cord-028721-x6f26ahr 1029 4 resembles resemble VBZ cord-028721-x6f26ahr 1029 5 fetal fetal JJ cord-028721-x6f26ahr 1029 6 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1029 7 and and CC cord-028721-x6f26ahr 1029 8 are be VBP cord-028721-x6f26ahr 1029 9 fewer few JJR cord-028721-x6f26ahr 1029 10 in in IN cord-028721-x6f26ahr 1029 11 number number NN cord-028721-x6f26ahr 1029 12 . . . cord-028721-x6f26ahr 1030 1 These these DT cord-028721-x6f26ahr 1030 2 structures structure NNS cord-028721-x6f26ahr 1030 3 contain contain VBP cord-028721-x6f26ahr 1030 4 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 1030 5 , , , cord-028721-x6f26ahr 1030 6 periodic periodic JJ cord-028721-x6f26ahr 1030 7 acid acid NN cord-028721-x6f26ahr 1030 8 - - HYPH cord-028721-x6f26ahr 1030 9 Schiff Schiff NNP cord-028721-x6f26ahr 1030 10 - - HYPH cord-028721-x6f26ahr 1030 11 positive positive JJ cord-028721-x6f26ahr 1030 12 material material NN cord-028721-x6f26ahr 1030 13 , , , cord-028721-x6f26ahr 1030 14 similar similar JJ cord-028721-x6f26ahr 1030 15 to to IN cord-028721-x6f26ahr 1030 16 Call call VB cord-028721-x6f26ahr 1030 17 - - HYPH cord-028721-x6f26ahr 1030 18 Exner exner NN cord-028721-x6f26ahr 1030 19 bodies body NNS cord-028721-x6f26ahr 1030 20 ( ( -LRB- cord-028721-x6f26ahr 1030 21 Fig Fig NNP cord-028721-x6f26ahr 1030 22 . . . cord-028721-x6f26ahr 1030 23 12 12 CD cord-028721-x6f26ahr 1030 24 - - SYM cord-028721-x6f26ahr 1030 25 39 39 CD cord-028721-x6f26ahr 1030 26 ) ) -RRB- cord-028721-x6f26ahr 1030 27 . . . cord-028721-x6f26ahr 1031 1 There there EX cord-028721-x6f26ahr 1031 2 may may MD cord-028721-x6f26ahr 1031 3 be be VB cord-028721-x6f26ahr 1031 4 continuity continuity NN cord-028721-x6f26ahr 1031 5 between between IN cord-028721-x6f26ahr 1031 6 these these DT cord-028721-x6f26ahr 1031 7 structures structure NNS cord-028721-x6f26ahr 1031 8 and and CC cord-028721-x6f26ahr 1031 9 normal normal JJ cord-028721-x6f26ahr 1031 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 1031 11 tubules tubule NNS cord-028721-x6f26ahr 1031 12 . . . cord-028721-x6f26ahr 1032 1 The the DT cord-028721-x6f26ahr 1032 2 differential differential JJ cord-028721-x6f26ahr 1032 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1032 4 includes include VBZ cord-028721-x6f26ahr 1032 5 conditions condition NNS cord-028721-x6f26ahr 1032 6 showing show VBG cord-028721-x6f26ahr 1032 7 anomalous anomalous JJ cord-028721-x6f26ahr 1032 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 1032 9 tubules tubule NNS cord-028721-x6f26ahr 1032 10 at at IN cord-028721-x6f26ahr 1032 11 the the DT cord-028721-x6f26ahr 1032 12 gonadal gonadal JJ cord-028721-x6f26ahr 1032 13 periphery periphery NN cord-028721-x6f26ahr 1032 14 , , , cord-028721-x6f26ahr 1032 15 including include VBG cord-028721-x6f26ahr 1032 16 testicular testicular NN cord-028721-x6f26ahr 1032 17 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1032 18 and and CC cord-028721-x6f26ahr 1032 19 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1032 20 . . . cord-028721-x6f26ahr 1033 1 Testicular testicular NN cord-028721-x6f26ahr 1033 2 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1033 3 also also RB cord-028721-x6f26ahr 1033 4 presents present VBZ cord-028721-x6f26ahr 1033 5 tubular tubular JJ cord-028721-x6f26ahr 1033 6 or or CC cord-028721-x6f26ahr 1033 7 cord cord NN cord-028721-x6f26ahr 1033 8 - - HYPH cord-028721-x6f26ahr 1033 9 like like JJ cord-028721-x6f26ahr 1033 10 structures structure NNS cord-028721-x6f26ahr 1033 11 , , , cord-028721-x6f26ahr 1033 12 but but CC cord-028721-x6f26ahr 1033 13 these these DT cord-028721-x6f26ahr 1033 14 are be VBP cord-028721-x6f26ahr 1033 15 differentiated differentiate VBN cord-028721-x6f26ahr 1033 16 ( ( -LRB- cord-028721-x6f26ahr 1033 17 some some DT cord-028721-x6f26ahr 1033 18 form form NN cord-028721-x6f26ahr 1033 19 true true JJ cord-028721-x6f26ahr 1033 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 1033 21 tubules tubule NNS cord-028721-x6f26ahr 1033 22 ) ) -RRB- cord-028721-x6f26ahr 1033 23 and and CC cord-028721-x6f26ahr 1033 24 may may MD cord-028721-x6f26ahr 1033 25 also also RB cord-028721-x6f26ahr 1033 26 be be VB cord-028721-x6f26ahr 1033 27 present present JJ cord-028721-x6f26ahr 1033 28 within within IN cord-028721-x6f26ahr 1033 29 a a DT cord-028721-x6f26ahr 1033 30 poorly poorly RB cord-028721-x6f26ahr 1033 31 collagenized collagenize VBN cord-028721-x6f26ahr 1033 32 tunica tunica NNP cord-028721-x6f26ahr 1033 33 albuginea albuginea NNP cord-028721-x6f26ahr 1033 34 ; ; : cord-028721-x6f26ahr 1033 35 patients patient NNS cord-028721-x6f26ahr 1033 36 with with IN cord-028721-x6f26ahr 1033 37 testicular testicular JJ cord-028721-x6f26ahr 1033 38 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1033 39 are be VBP cord-028721-x6f26ahr 1033 40 male male JJ cord-028721-x6f26ahr 1033 41 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 1033 42 with with IN cord-028721-x6f26ahr 1033 43 müllerian müllerian JJ cord-028721-x6f26ahr 1033 44 remnants remnant NNS cord-028721-x6f26ahr 1033 45 . . . cord-028721-x6f26ahr 1034 1 Gonadoblastoma Gonadoblastoma NNP cord-028721-x6f26ahr 1034 2 usually usually RB cord-028721-x6f26ahr 1034 3 appears appear VBZ cord-028721-x6f26ahr 1034 4 in in IN cord-028721-x6f26ahr 1034 5 a a DT cord-028721-x6f26ahr 1034 6 streak streak NN cord-028721-x6f26ahr 1034 7 gonad gonad NN cord-028721-x6f26ahr 1034 8 or or CC cord-028721-x6f26ahr 1034 9 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1034 10 gonad gonad NN cord-028721-x6f26ahr 1034 11 and and CC cord-028721-x6f26ahr 1034 12 contains contain VBZ cord-028721-x6f26ahr 1034 13 granulosa granulosa NN cord-028721-x6f26ahr 1034 14 - - HYPH cord-028721-x6f26ahr 1034 15 Sertoli sertoli JJ cord-028721-x6f26ahr 1034 16 cells cell NNS cord-028721-x6f26ahr 1034 17 and and CC cord-028721-x6f26ahr 1034 18 germ germ NN cord-028721-x6f26ahr 1034 19 cells cell NNS cord-028721-x6f26ahr 1034 20 that that WDT cord-028721-x6f26ahr 1034 21 are be VBP cord-028721-x6f26ahr 1034 22 similar similar JJ cord-028721-x6f26ahr 1034 23 to to IN cord-028721-x6f26ahr 1034 24 those those DT cord-028721-x6f26ahr 1034 25 of of IN cord-028721-x6f26ahr 1034 26 dysgerminoma dysgerminoma NN cord-028721-x6f26ahr 1034 27 or or CC cord-028721-x6f26ahr 1034 28 seminoma seminoma NN cord-028721-x6f26ahr 1034 29 ; ; : cord-028721-x6f26ahr 1034 30 these these DT cord-028721-x6f26ahr 1034 31 cells cell NNS cord-028721-x6f26ahr 1034 32 are be VBP cord-028721-x6f26ahr 1034 33 absent absent JJ cord-028721-x6f26ahr 1034 34 in in IN cord-028721-x6f26ahr 1034 35 gonadoblastoid gonadoblastoid JJ cord-028721-x6f26ahr 1034 36 testicular testicular JJ cord-028721-x6f26ahr 1034 37 dysplasia dysplasia NN cord-028721-x6f26ahr 1034 38 . . . cord-028721-x6f26ahr 1035 1 Several several JJ cord-028721-x6f26ahr 1035 2 cases case NNS cord-028721-x6f26ahr 1035 3 with with IN cord-028721-x6f26ahr 1035 4 this this DT cord-028721-x6f26ahr 1035 5 disorder disorder NN cord-028721-x6f26ahr 1035 6 have have VBP cord-028721-x6f26ahr 1035 7 been be VBN cord-028721-x6f26ahr 1035 8 reported report VBN cord-028721-x6f26ahr 1035 9 in in IN cord-028721-x6f26ahr 1035 10 patients patient NNS cord-028721-x6f26ahr 1035 11 with with IN cord-028721-x6f26ahr 1035 12 Walker Walker NNP cord-028721-x6f26ahr 1035 13 - - HYPH cord-028721-x6f26ahr 1035 14 Warburg Warburg NNP cord-028721-x6f26ahr 1035 15 syndrome syndrome NN cord-028721-x6f26ahr 1035 16 . . . cord-028721-x6f26ahr 1036 1 457 457 CD cord-028721-x6f26ahr 1036 2 , , , cord-028721-x6f26ahr 1036 3 458 458 CD cord-028721-x6f26ahr 1036 4 _SP cord-028721-x6f26ahr 1037 1 This this DT cord-028721-x6f26ahr 1037 2 disorder disorder NN cord-028721-x6f26ahr 1037 3 refers refer VBZ cord-028721-x6f26ahr 1037 4 to to IN cord-028721-x6f26ahr 1037 5 the the DT cord-028721-x6f26ahr 1037 6 presence presence NN cord-028721-x6f26ahr 1037 7 , , , cord-028721-x6f26ahr 1037 8 in in IN cord-028721-x6f26ahr 1037 9 an an DT cord-028721-x6f26ahr 1037 10 adult adult NN cord-028721-x6f26ahr 1037 11 testis testis NN cord-028721-x6f26ahr 1037 12 , , , cord-028721-x6f26ahr 1037 13 of of IN cord-028721-x6f26ahr 1037 14 one one CD cord-028721-x6f26ahr 1037 15 or or CC cord-028721-x6f26ahr 1037 16 several several JJ cord-028721-x6f26ahr 1037 17 foci foci NN cord-028721-x6f26ahr 1037 18 of of IN cord-028721-x6f26ahr 1037 19 infantile infantile JJ cord-028721-x6f26ahr 1037 20 ( ( -LRB- cord-028721-x6f26ahr 1037 21 immature immature JJ cord-028721-x6f26ahr 1037 22 ) ) -RRB- cord-028721-x6f26ahr 1037 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 1037 24 tubules tubule NNS cord-028721-x6f26ahr 1037 25 . . . cord-028721-x6f26ahr 1038 1 Each each DT cord-028721-x6f26ahr 1038 2 group group NN cord-028721-x6f26ahr 1038 3 of of IN cord-028721-x6f26ahr 1038 4 tubules tubule NNS cord-028721-x6f26ahr 1038 5 appears appear VBZ cord-028721-x6f26ahr 1038 6 well well RB cord-028721-x6f26ahr 1038 7 delimited delimited JJ cord-028721-x6f26ahr 1038 8 but but CC cord-028721-x6f26ahr 1038 9 unencapsulated unencapsulated JJ cord-028721-x6f26ahr 1038 10 . . . cord-028721-x6f26ahr 1039 1 Nodule nodule NN cord-028721-x6f26ahr 1039 2 size size NN cord-028721-x6f26ahr 1039 3 varies vary VBZ cord-028721-x6f26ahr 1039 4 from from IN cord-028721-x6f26ahr 1039 5 microscopic microscopic JJ cord-028721-x6f26ahr 1039 6 to to IN cord-028721-x6f26ahr 1039 7 5 5 CD cord-028721-x6f26ahr 1039 8 mm mm NNS cord-028721-x6f26ahr 1039 9 . . . cord-028721-x6f26ahr 1040 1 On on IN cord-028721-x6f26ahr 1040 2 section section NN cord-028721-x6f26ahr 1040 3 , , , cord-028721-x6f26ahr 1040 4 each each DT cord-028721-x6f26ahr 1040 5 nodule nodule NN cord-028721-x6f26ahr 1040 6 is be VBZ cord-028721-x6f26ahr 1040 7 distinguished distinguish VBN cord-028721-x6f26ahr 1040 8 by by IN cord-028721-x6f26ahr 1040 9 its -PRON- PRP$ cord-028721-x6f26ahr 1040 10 whitish whitish JJ cord-028721-x6f26ahr 1040 11 color color NN cord-028721-x6f26ahr 1040 12 . . . cord-028721-x6f26ahr 1041 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1041 2 cell cell NN cord-028721-x6f26ahr 1041 3 nodule nodule NN cord-028721-x6f26ahr 1041 4 is be VBZ cord-028721-x6f26ahr 1041 5 found find VBN cord-028721-x6f26ahr 1041 6 in in IN cord-028721-x6f26ahr 1041 7 most most JJS cord-028721-x6f26ahr 1041 8 adult adult NN cord-028721-x6f26ahr 1041 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1041 10 testes testis NNS cord-028721-x6f26ahr 1041 11 , , , cord-028721-x6f26ahr 1041 12 regardless regardless RB cord-028721-x6f26ahr 1041 13 of of IN cord-028721-x6f26ahr 1041 14 when when WRB cord-028721-x6f26ahr 1041 15 the the DT cord-028721-x6f26ahr 1041 16 testes testis NNS cord-028721-x6f26ahr 1041 17 descended descend VBD cord-028721-x6f26ahr 1041 18 . . . cord-028721-x6f26ahr 1042 1 It -PRON- PRP cord-028721-x6f26ahr 1042 2 is be VBZ cord-028721-x6f26ahr 1042 3 also also RB cord-028721-x6f26ahr 1042 4 present present JJ cord-028721-x6f26ahr 1042 5 in in IN cord-028721-x6f26ahr 1042 6 22 22 CD cord-028721-x6f26ahr 1042 7 % % NN cord-028721-x6f26ahr 1042 8 of of IN cord-028721-x6f26ahr 1042 9 normal normal JJ cord-028721-x6f26ahr 1042 10 scrotal scrotal JJ cord-028721-x6f26ahr 1042 11 testes testis NNS cord-028721-x6f26ahr 1042 12 in in IN cord-028721-x6f26ahr 1042 13 some some DT cord-028721-x6f26ahr 1042 14 series series NN cord-028721-x6f26ahr 1042 15 , , , cord-028721-x6f26ahr 1042 16 459 459 CD cord-028721-x6f26ahr 1042 17 and and CC cord-028721-x6f26ahr 1042 18 is be VBZ cord-028721-x6f26ahr 1042 19 an an DT cord-028721-x6f26ahr 1042 20 occasional occasional JJ cord-028721-x6f26ahr 1042 21 fi fi NN cord-028721-x6f26ahr 1042 22 nding nding NN cord-028721-x6f26ahr 1042 23 in in IN cord-028721-x6f26ahr 1042 24 males male NNS cord-028721-x6f26ahr 1042 25 with with IN cord-028721-x6f26ahr 1042 26 idiopathic idiopathic JJ cord-028721-x6f26ahr 1042 27 infertility infertility NN cord-028721-x6f26ahr 1042 28 . . . cord-028721-x6f26ahr 1043 1 The the DT cord-028721-x6f26ahr 1043 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1043 3 tubules tubule NNS cord-028721-x6f26ahr 1043 4 have have VBP cord-028721-x6f26ahr 1043 5 a a DT cord-028721-x6f26ahr 1043 6 prepubertal prepubertal JJ cord-028721-x6f26ahr 1043 7 diameter diameter NN cord-028721-x6f26ahr 1043 8 and and CC cord-028721-x6f26ahr 1043 9 may may MD cord-028721-x6f26ahr 1043 10 be be VB cord-028721-x6f26ahr 1043 11 anastomotic anastomotic VBN cord-028721-x6f26ahr 1043 12 . . . cord-028721-x6f26ahr 1044 1 The the DT cord-028721-x6f26ahr 1044 2 epithelium epithelium NN cord-028721-x6f26ahr 1044 3 is be VBZ cord-028721-x6f26ahr 1044 4 columnar columnar JJ cord-028721-x6f26ahr 1044 5 or or CC cord-028721-x6f26ahr 1044 6 pseudostratifi pseudostratifi JJ cord-028721-x6f26ahr 1044 7 ed ed NN cord-028721-x6f26ahr 1044 8 , , , cord-028721-x6f26ahr 1044 9 devoid devoid JJ cord-028721-x6f26ahr 1044 10 of of IN cord-028721-x6f26ahr 1044 11 lumina lumina NNP cord-028721-x6f26ahr 1044 12 , , , cord-028721-x6f26ahr 1044 13 and and CC cord-028721-x6f26ahr 1044 14 usually usually RB cord-028721-x6f26ahr 1044 15 consists consist VBZ cord-028721-x6f26ahr 1044 16 only only RB cord-028721-x6f26ahr 1044 17 of of IN cord-028721-x6f26ahr 1044 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 1044 19 cells cell NNS cord-028721-x6f26ahr 1044 20 ( ( -LRB- cord-028721-x6f26ahr 1044 21 Fig Fig NNP cord-028721-x6f26ahr 1044 22 . . . cord-028721-x6f26ahr 1044 23 12 12 CD cord-028721-x6f26ahr 1044 24 - - SYM cord-028721-x6f26ahr 1044 25 40 40 CD cord-028721-x6f26ahr 1044 26 ) ) -RRB- cord-028721-x6f26ahr 1044 27 . . . cord-028721-x6f26ahr 1045 1 The the DT cord-028721-x6f26ahr 1045 2 cells cell NNS cord-028721-x6f26ahr 1045 3 have have VBP cord-028721-x6f26ahr 1045 4 elongated elongate VBN cord-028721-x6f26ahr 1045 5 hyperchromatic hyperchromatic JJ cord-028721-x6f26ahr 1045 6 nuclei nucleus NNS cord-028721-x6f26ahr 1045 7 with with IN cord-028721-x6f26ahr 1045 8 one one CD cord-028721-x6f26ahr 1045 9 or or CC cord-028721-x6f26ahr 1045 10 several several JJ cord-028721-x6f26ahr 1045 11 peripherally peripherally RB cord-028721-x6f26ahr 1045 12 placed place VBD cord-028721-x6f26ahr 1045 13 small small JJ cord-028721-x6f26ahr 1045 14 nucleoli nucleolus NNS cord-028721-x6f26ahr 1045 15 . . . cord-028721-x6f26ahr 1046 1 459 459 CD cord-028721-x6f26ahr 1047 1 The the DT cord-028721-x6f26ahr 1047 2 interstitium interstitium NN cord-028721-x6f26ahr 1047 3 varies vary VBZ cord-028721-x6f26ahr 1047 4 from from IN cord-028721-x6f26ahr 1047 5 scant scant JJ cord-028721-x6f26ahr 1047 6 to to IN cord-028721-x6f26ahr 1047 7 well well RB cord-028721-x6f26ahr 1047 8 collagenized collagenized JJ cord-028721-x6f26ahr 1047 9 . . . cord-028721-x6f26ahr 1048 1 Leydig leydig NN cord-028721-x6f26ahr 1048 2 cells cell NNS cord-028721-x6f26ahr 1048 3 are be VBP cord-028721-x6f26ahr 1048 4 usually usually RB cord-028721-x6f26ahr 1048 5 absent absent JJ cord-028721-x6f26ahr 1048 6 in in IN cord-028721-x6f26ahr 1048 7 these these DT cord-028721-x6f26ahr 1048 8 areas area NNS cord-028721-x6f26ahr 1048 9 and and CC cord-028721-x6f26ahr 1048 10 , , , cord-028721-x6f26ahr 1048 11 if if IN cord-028721-x6f26ahr 1048 12 present present JJ cord-028721-x6f26ahr 1048 13 , , , cord-028721-x6f26ahr 1048 14 their -PRON- PRP$ cord-028721-x6f26ahr 1048 15 numbers number NNS cord-028721-x6f26ahr 1048 16 are be VBP cord-028721-x6f26ahr 1048 17 low low JJ cord-028721-x6f26ahr 1048 18 . . . cord-028721-x6f26ahr 1049 1 Study study NN cord-028721-x6f26ahr 1049 2 of of IN cord-028721-x6f26ahr 1049 3 serial serial JJ cord-028721-x6f26ahr 1049 4 sections section NNS cord-028721-x6f26ahr 1049 5 reveals reveal VBZ cord-028721-x6f26ahr 1049 6 continuity continuity NN cord-028721-x6f26ahr 1049 7 between between IN cord-028721-x6f26ahr 1049 8 some some DT cord-028721-x6f26ahr 1049 9 of of IN cord-028721-x6f26ahr 1049 10 these these DT cord-028721-x6f26ahr 1049 11 tubules tubule NNS cord-028721-x6f26ahr 1049 12 and and CC cord-028721-x6f26ahr 1049 13 normal normal JJ cord-028721-x6f26ahr 1049 14 tubules tubule NNS cord-028721-x6f26ahr 1049 15 . . . cord-028721-x6f26ahr 1050 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1050 2 cell cell NN cord-028721-x6f26ahr 1050 3 nodule nodule NN cord-028721-x6f26ahr 1050 4 changes change VBZ cord-028721-x6f26ahr 1050 5 with with IN cord-028721-x6f26ahr 1050 6 advancing advance VBG cord-028721-x6f26ahr 1050 7 age age NN cord-028721-x6f26ahr 1050 8 . . . cord-028721-x6f26ahr 1051 1 The the DT cord-028721-x6f26ahr 1051 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 1051 3 cells cell NNS cord-028721-x6f26ahr 1051 4 produce produce VBP cord-028721-x6f26ahr 1051 5 large large JJ cord-028721-x6f26ahr 1051 6 amounts amount NNS cord-028721-x6f26ahr 1051 7 of of IN cord-028721-x6f26ahr 1051 8 basal basal NN cord-028721-x6f26ahr 1051 9 lamina lamina NN cord-028721-x6f26ahr 1051 10 that that WDT cord-028721-x6f26ahr 1051 11 protrudes protrude VBZ cord-028721-x6f26ahr 1051 12 inside inside IN cord-028721-x6f26ahr 1051 13 the the DT cord-028721-x6f26ahr 1051 14 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1051 15 tubules tubule NNS cord-028721-x6f26ahr 1051 16 . . . cord-028721-x6f26ahr 1052 1 In in IN cord-028721-x6f26ahr 1052 2 transverse transverse JJ cord-028721-x6f26ahr 1052 3 and and CC cord-028721-x6f26ahr 1052 4 oblique oblique JJ cord-028721-x6f26ahr 1052 5 sections section NNS cord-028721-x6f26ahr 1052 6 , , , cord-028721-x6f26ahr 1052 7 these these DT cord-028721-x6f26ahr 1052 8 protrusions protrusion NNS cord-028721-x6f26ahr 1052 9 might may MD cord-028721-x6f26ahr 1052 10 be be VB cord-028721-x6f26ahr 1052 11 misinterpreted misinterpret VBN cord-028721-x6f26ahr 1052 12 as as IN cord-028721-x6f26ahr 1052 13 intratubular intratubular JJ cord-028721-x6f26ahr 1052 14 accumulations accumulation NNS cord-028721-x6f26ahr 1052 15 of of IN cord-028721-x6f26ahr 1052 16 basal basal NN cord-028721-x6f26ahr 1052 17 lamina lamina JJ cord-028721-x6f26ahr 1052 18 material material NN cord-028721-x6f26ahr 1052 19 ( ( -LRB- cord-028721-x6f26ahr 1052 20 Fig Fig NNP cord-028721-x6f26ahr 1052 21 . . . cord-028721-x6f26ahr 1052 22 12 12 CD cord-028721-x6f26ahr 1052 23 - - SYM cord-028721-x6f26ahr 1052 24 41 41 CD cord-028721-x6f26ahr 1052 25 ) ) -RRB- cord-028721-x6f26ahr 1052 26 . . . cord-028721-x6f26ahr 1053 1 This this DT cord-028721-x6f26ahr 1053 2 material material NN cord-028721-x6f26ahr 1053 3 can can MD cord-028721-x6f26ahr 1053 4 undergo undergo VB cord-028721-x6f26ahr 1053 5 calcifi calcifi NNP cord-028721-x6f26ahr 1053 6 cation cation NN cord-028721-x6f26ahr 1053 7 to to TO cord-028721-x6f26ahr 1053 8 form form VB cord-028721-x6f26ahr 1053 9 microliths microlith NNS cord-028721-x6f26ahr 1053 10 . . . cord-028721-x6f26ahr 1054 1 Immunohistochemical Immunohistochemical NNP cord-028721-x6f26ahr 1054 2 study study NN cord-028721-x6f26ahr 1054 3 reveals reveal VBZ cord-028721-x6f26ahr 1054 4 two two CD cord-028721-x6f26ahr 1054 5 basic basic JJ cord-028721-x6f26ahr 1054 6 components component NNS cord-028721-x6f26ahr 1054 7 of of IN cord-028721-x6f26ahr 1054 8 the the DT cord-028721-x6f26ahr 1054 9 basal basal NN cord-028721-x6f26ahr 1054 10 lamina lamina NN cord-028721-x6f26ahr 1054 11 ( ( -LRB- cord-028721-x6f26ahr 1054 12 collagen collagen NNP cord-028721-x6f26ahr 1054 13 IV IV NNP cord-028721-x6f26ahr 1054 14 and and CC cord-028721-x6f26ahr 1054 15 laminin laminin NNP cord-028721-x6f26ahr 1054 16 ) ) -RRB- cord-028721-x6f26ahr 1054 17 , , , cord-028721-x6f26ahr 1054 18 confi confi NNP cord-028721-x6f26ahr 1054 19 rming rme VBG cord-028721-x6f26ahr 1054 20 its -PRON- PRP$ cord-028721-x6f26ahr 1054 21 extracellular extracellular JJ cord-028721-x6f26ahr 1054 22 origin origin NN cord-028721-x6f26ahr 1054 23 ; ; : cord-028721-x6f26ahr 1054 24 the the DT cord-028721-x6f26ahr 1054 25 protrusions protrusion NNS cord-028721-x6f26ahr 1054 26 consist consist VBP cord-028721-x6f26ahr 1054 27 mainly mainly RB cord-028721-x6f26ahr 1054 28 of of IN cord-028721-x6f26ahr 1054 29 laminin laminin NN cord-028721-x6f26ahr 1054 30 , , , cord-028721-x6f26ahr 1054 31 whereas whereas IN cord-028721-x6f26ahr 1054 32 collagen collagen NNP cord-028721-x6f26ahr 1054 33 IV IV NNP cord-028721-x6f26ahr 1054 34 delimits delimit VBZ cord-028721-x6f26ahr 1054 35 the the DT cord-028721-x6f26ahr 1054 36 outer outer JJ cord-028721-x6f26ahr 1054 37 profi profi NNP cord-028721-x6f26ahr 1054 38 le le NNP cord-028721-x6f26ahr 1054 39 of of IN cord-028721-x6f26ahr 1054 40 the the DT cord-028721-x6f26ahr 1054 41 seminiferous seminiferous JJ cord-028721-x6f26ahr 1054 42 tubules tubule NNS cord-028721-x6f26ahr 1054 43 . . . cord-028721-x6f26ahr 1055 1 So so RB cord-028721-x6f26ahr 1055 2 , , , cord-028721-x6f26ahr 1055 3 while while IN cord-028721-x6f26ahr 1055 4 the the DT cord-028721-x6f26ahr 1055 5 amount amount NN cord-028721-x6f26ahr 1055 6 of of IN cord-028721-x6f26ahr 1055 7 collagen collagen NN cord-028721-x6f26ahr 1055 8 IV IV NNP cord-028721-x6f26ahr 1055 9 is be VBZ cord-028721-x6f26ahr 1055 10 uniform uniform JJ cord-028721-x6f26ahr 1055 11 around around IN cord-028721-x6f26ahr 1055 12 the the DT cord-028721-x6f26ahr 1055 13 tubules tubule NNS cord-028721-x6f26ahr 1055 14 , , , cord-028721-x6f26ahr 1055 15 the the DT cord-028721-x6f26ahr 1055 16 depth depth NN cord-028721-x6f26ahr 1055 17 of of IN cord-028721-x6f26ahr 1055 18 laminin laminin NN cord-028721-x6f26ahr 1055 19 varies vary VBZ cord-028721-x6f26ahr 1055 20 within within IN cord-028721-x6f26ahr 1055 21 the the DT cord-028721-x6f26ahr 1055 22 same same JJ cord-028721-x6f26ahr 1055 23 tubule tubule NN cord-028721-x6f26ahr 1055 24 . . . cord-028721-x6f26ahr 1056 1 Tubular tubular JJ cord-028721-x6f26ahr 1056 2 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1056 3 is be VBZ cord-028721-x6f26ahr 1056 4 assumed assume VBN cord-028721-x6f26ahr 1056 5 to to TO cord-028721-x6f26ahr 1056 6 be be VB cord-028721-x6f26ahr 1056 7 a a DT cord-028721-x6f26ahr 1056 8 primary primary JJ cord-028721-x6f26ahr 1056 9 testicular testicular JJ cord-028721-x6f26ahr 1056 10 lesion lesion NN cord-028721-x6f26ahr 1056 11 , , , cord-028721-x6f26ahr 1056 12 and and CC cord-028721-x6f26ahr 1056 13 refers refer VBZ cord-028721-x6f26ahr 1056 14 to to IN cord-028721-x6f26ahr 1056 15 the the DT cord-028721-x6f26ahr 1056 16 presence presence NN cord-028721-x6f26ahr 1056 17 of of IN cord-028721-x6f26ahr 1056 18 seminiferous seminiferous JJ cord-028721-x6f26ahr 1056 19 tubules tubule NNS cord-028721-x6f26ahr 1056 20 that that WDT cord-028721-x6f26ahr 1056 21 are be VBP cord-028721-x6f26ahr 1056 22 unable unable JJ cord-028721-x6f26ahr 1056 23 to to TO cord-028721-x6f26ahr 1056 24 undergo undergo VB cord-028721-x6f26ahr 1056 25 pubertal pubertal JJ cord-028721-x6f26ahr 1056 26 development development NN cord-028721-x6f26ahr 1056 27 despite despite IN cord-028721-x6f26ahr 1056 28 the the DT cord-028721-x6f26ahr 1056 29 same same JJ cord-028721-x6f26ahr 1056 30 hormonal hormonal JJ cord-028721-x6f26ahr 1056 31 stimuli stimulus NNS cord-028721-x6f26ahr 1056 32 of of IN cord-028721-x6f26ahr 1056 33 adjacent adjacent JJ cord-028721-x6f26ahr 1056 34 normal normal JJ cord-028721-x6f26ahr 1056 35 tubules tubule NNS cord-028721-x6f26ahr 1056 36 . . . cord-028721-x6f26ahr 1057 1 This this DT cord-028721-x6f26ahr 1057 2 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1057 3 includes include VBZ cord-028721-x6f26ahr 1057 4 immature immature JJ cord-028721-x6f26ahr 1057 5 Sertoli sertoli JJ cord-028721-x6f26ahr 1057 6 cell cell NN cord-028721-x6f26ahr 1057 7 pattern pattern NN cord-028721-x6f26ahr 1057 8 , , , cord-028721-x6f26ahr 1057 9 low low JJ cord-028721-x6f26ahr 1057 10 inhibin inhibin NN cord-028721-x6f26ahr 1057 11 secretion secretion NN cord-028721-x6f26ahr 1057 12 , , , cord-028721-x6f26ahr 1057 13 absence absence NN cord-028721-x6f26ahr 1057 14 of of IN cord-028721-x6f26ahr 1057 15 androgen androgen NN cord-028721-x6f26ahr 1057 16 receptors receptor NNS cord-028721-x6f26ahr 1057 17 , , , cord-028721-x6f26ahr 1057 18 460 460 CD cord-028721-x6f26ahr 1057 19 and and CC cord-028721-x6f26ahr 1057 20 lack lack NN cord-028721-x6f26ahr 1057 21 of of IN cord-028721-x6f26ahr 1057 22 maturation maturation NN cord-028721-x6f26ahr 1057 23 of of IN cord-028721-x6f26ahr 1057 24 peritubular peritubular NNP cord-028721-x6f26ahr 1057 25 myoid myoid NNP cord-028721-x6f26ahr 1057 26 cells cell NNS cord-028721-x6f26ahr 1057 27 that that WDT cord-028721-x6f26ahr 1057 28 fail fail VBP cord-028721-x6f26ahr 1057 29 to to TO cord-028721-x6f26ahr 1057 30 synthesize synthesize VB cord-028721-x6f26ahr 1057 31 elastic elastic JJ cord-028721-x6f26ahr 1057 32 fi fi NN cord-028721-x6f26ahr 1057 33 bers ber NNS cord-028721-x6f26ahr 1057 34 . . . cord-028721-x6f26ahr 1058 1 The the DT cord-028721-x6f26ahr 1058 2 presence presence NN cord-028721-x6f26ahr 1058 3 of of IN cord-028721-x6f26ahr 1058 4 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1058 5 zones zone NNS cord-028721-x6f26ahr 1058 6 in in IN cord-028721-x6f26ahr 1058 7 a a DT cord-028721-x6f26ahr 1058 8 testicular testicular JJ cord-028721-x6f26ahr 1058 9 biopsy biopsy NN cord-028721-x6f26ahr 1058 10 is be VBZ cord-028721-x6f26ahr 1058 11 an an DT cord-028721-x6f26ahr 1058 12 adverse adverse JJ cord-028721-x6f26ahr 1058 13 prognostic prognostic JJ cord-028721-x6f26ahr 1058 14 sign sign NN cord-028721-x6f26ahr 1058 15 for for IN cord-028721-x6f26ahr 1058 16 fertility fertility NN cord-028721-x6f26ahr 1058 17 . . . cord-028721-x6f26ahr 1059 1 The the DT cord-028721-x6f26ahr 1059 2 differential differential JJ cord-028721-x6f26ahr 1059 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1059 4 includes include VBZ cord-028721-x6f26ahr 1059 5 tubular tubular JJ cord-028721-x6f26ahr 1059 6 hamartoma hamartoma NN cord-028721-x6f26ahr 1059 7 in in IN cord-028721-x6f26ahr 1059 8 androgen androgen NN cord-028721-x6f26ahr 1059 9 insensitivity insensitivity NN cord-028721-x6f26ahr 1059 10 syndrome syndrome NN cord-028721-x6f26ahr 1059 11 , , , cord-028721-x6f26ahr 1059 12 sex sex NN cord-028721-x6f26ahr 1059 13 cord cord NN cord-028721-x6f26ahr 1059 14 tumor tumor NN cord-028721-x6f26ahr 1059 15 with with IN cord-028721-x6f26ahr 1059 16 annular annular JJ cord-028721-x6f26ahr 1059 17 tubules tubule NNS cord-028721-x6f26ahr 1059 18 , , , cord-028721-x6f26ahr 1059 19 and and CC cord-028721-x6f26ahr 1059 20 mixed mixed JJ cord-028721-x6f26ahr 1059 21 atrophy atrophy NN cord-028721-x6f26ahr 1059 22 of of IN cord-028721-x6f26ahr 1059 23 the the DT cord-028721-x6f26ahr 1059 24 testis testis NN cord-028721-x6f26ahr 1059 25 . . . cord-028721-x6f26ahr 1060 1 Tubular tubular JJ cord-028721-x6f26ahr 1060 2 hamartoma hamartoma NN cord-028721-x6f26ahr 1060 3 in in IN cord-028721-x6f26ahr 1060 4 androgen androgen NN cord-028721-x6f26ahr 1060 5 insensitivity insensitivity NN cord-028721-x6f26ahr 1060 6 syndrome syndrome NN cord-028721-x6f26ahr 1060 7 is be VBZ cord-028721-x6f26ahr 1060 8 multiple multiple JJ cord-028721-x6f26ahr 1060 9 , , , cord-028721-x6f26ahr 1060 10 similar similar JJ cord-028721-x6f26ahr 1060 11 to to IN cord-028721-x6f26ahr 1060 12 the the DT cord-028721-x6f26ahr 1060 13 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1060 14 zones zone NNS cord-028721-x6f26ahr 1060 15 of of IN cord-028721-x6f26ahr 1060 16 tubular tubular JJ cord-028721-x6f26ahr 1060 17 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1060 18 ; ; : cord-028721-x6f26ahr 1060 19 however however RB cord-028721-x6f26ahr 1060 20 , , , cord-028721-x6f26ahr 1060 21 the the DT cord-028721-x6f26ahr 1060 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 1060 23 - - HYPH cord-028721-x6f26ahr 1060 24 like like JJ cord-028721-x6f26ahr 1060 25 cells cell NNS cord-028721-x6f26ahr 1060 26 of of IN cord-028721-x6f26ahr 1060 27 hamartoma hamartoma NNP cord-028721-x6f26ahr 1060 28 have have VBP cord-028721-x6f26ahr 1060 29 spherical spherical JJ cord-028721-x6f26ahr 1060 30 nuclei nucleus NNS cord-028721-x6f26ahr 1060 31 ( ( -LRB- cord-028721-x6f26ahr 1060 32 rather rather RB cord-028721-x6f26ahr 1060 33 of of IN cord-028721-x6f26ahr 1060 34 elongated elongated JJ cord-028721-x6f26ahr 1060 35 nuclei nucleus NNS cord-028721-x6f26ahr 1060 36 ) ) -RRB- cord-028721-x6f26ahr 1060 37 , , , cord-028721-x6f26ahr 1060 38 form form VB cord-028721-x6f26ahr 1060 39 a a DT cord-028721-x6f26ahr 1060 40 cuboidal cuboidal JJ cord-028721-x6f26ahr 1060 41 epithelium epithelium NN cord-028721-x6f26ahr 1060 42 , , , cord-028721-x6f26ahr 1060 43 and and CC cord-028721-x6f26ahr 1060 44 contain contain VBP cord-028721-x6f26ahr 1060 45 numerous numerous JJ cord-028721-x6f26ahr 1060 46 Leydig Leydig NNP cord-028721-x6f26ahr 1060 47 cells cell NNS cord-028721-x6f26ahr 1060 48 among among IN cord-028721-x6f26ahr 1060 49 the the DT cord-028721-x6f26ahr 1060 50 tubules tubule NNS cord-028721-x6f26ahr 1060 51 ( ( -LRB- cord-028721-x6f26ahr 1060 52 see see VB cord-028721-x6f26ahr 1060 53 Androgen androgen NN cord-028721-x6f26ahr 1060 54 insensitivity insensitivity NN cord-028721-x6f26ahr 1060 55 syndrome syndrome NN cord-028721-x6f26ahr 1060 56 , , , cord-028721-x6f26ahr 1060 57 below below RB cord-028721-x6f26ahr 1060 58 ) ) -RRB- cord-028721-x6f26ahr 1060 59 . . . cord-028721-x6f26ahr 1061 1 Sex sex NN cord-028721-x6f26ahr 1061 2 cord cord NN cord-028721-x6f26ahr 1061 3 tumor tumor NN cord-028721-x6f26ahr 1061 4 with with IN cord-028721-x6f26ahr 1061 5 annular annular JJ cord-028721-x6f26ahr 1061 6 tubules tubule NNS cord-028721-x6f26ahr 1061 7 may may MD cord-028721-x6f26ahr 1061 8 present present VB cord-028721-x6f26ahr 1061 9 with with IN cord-028721-x6f26ahr 1061 10 multiple multiple JJ cord-028721-x6f26ahr 1061 11 foci focus NNS cord-028721-x6f26ahr 1061 12 of of IN cord-028721-x6f26ahr 1061 13 intratubular intratubular JJ cord-028721-x6f26ahr 1061 14 neoplasia neoplasia NN cord-028721-x6f26ahr 1061 15 , , , cord-028721-x6f26ahr 1061 16 similar similar JJ cord-028721-x6f26ahr 1061 17 in in IN cord-028721-x6f26ahr 1061 18 distribution distribution NN cord-028721-x6f26ahr 1061 19 to to IN cord-028721-x6f26ahr 1061 20 that that DT cord-028721-x6f26ahr 1061 21 of of IN cord-028721-x6f26ahr 1061 22 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1061 23 zones zone NNS cord-028721-x6f26ahr 1061 24 ; ; : cord-028721-x6f26ahr 1061 25 however however RB cord-028721-x6f26ahr 1061 26 , , , cord-028721-x6f26ahr 1061 27 sex sex NN cord-028721-x6f26ahr 1061 28 cord cord NN cord-028721-x6f26ahr 1061 29 tumor tumor NN cord-028721-x6f26ahr 1061 30 appears appear VBZ cord-028721-x6f26ahr 1061 31 in in IN cord-028721-x6f26ahr 1061 32 undescended undescended JJ cord-028721-x6f26ahr 1061 33 testes testis NNS cord-028721-x6f26ahr 1061 34 , , , cord-028721-x6f26ahr 1061 35 and and CC cord-028721-x6f26ahr 1061 36 in in IN cord-028721-x6f26ahr 1061 37 patients patient NNS cord-028721-x6f26ahr 1061 38 with with IN cord-028721-x6f26ahr 1061 39 Peutz Peutz NNP cord-028721-x6f26ahr 1061 40 - - HYPH cord-028721-x6f26ahr 1061 41 Jeghers Jeghers NNP cord-028721-x6f26ahr 1061 42 syndrome syndrome NN cord-028721-x6f26ahr 1061 43 , , , cord-028721-x6f26ahr 1061 44 and and CC cord-028721-x6f26ahr 1061 45 consists consist VBZ cord-028721-x6f26ahr 1061 46 of of IN cord-028721-x6f26ahr 1061 47 cuboidal cuboidal JJ cord-028721-x6f26ahr 1061 48 or or CC cord-028721-x6f26ahr 1061 49 spherical spherical JJ cord-028721-x6f26ahr 1061 50 cells cell NNS cord-028721-x6f26ahr 1061 51 that that WDT cord-028721-x6f26ahr 1061 52 express express VBP cord-028721-x6f26ahr 1061 53 cytokeratins cytokeratin NNS cord-028721-x6f26ahr 1061 54 that that WDT cord-028721-x6f26ahr 1061 55 are be VBP cord-028721-x6f26ahr 1061 56 not not RB cord-028721-x6f26ahr 1061 57 expressed express VBN cord-028721-x6f26ahr 1061 58 in in IN cord-028721-x6f26ahr 1061 59 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1061 60 tubules tubule NNS cord-028721-x6f26ahr 1061 61 . . . cord-028721-x6f26ahr 1062 1 It -PRON- PRP cord-028721-x6f26ahr 1062 2 is be VBZ cord-028721-x6f26ahr 1062 3 possible possible JJ cord-028721-x6f26ahr 1062 4 that that IN cord-028721-x6f26ahr 1062 5 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1062 6 tubules tubule NNS cord-028721-x6f26ahr 1062 7 contain contain VBP cord-028721-x6f26ahr 1062 8 some some DT cord-028721-x6f26ahr 1062 9 germ germ NN cord-028721-x6f26ahr 1062 10 cells cell NNS cord-028721-x6f26ahr 1062 11 that that WDT cord-028721-x6f26ahr 1062 12 may may MD cord-028721-x6f26ahr 1062 13 be be VB cord-028721-x6f26ahr 1062 14 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1062 15 or or CC cord-028721-x6f26ahr 1062 16 gonocytes gonocyte NNS cord-028721-x6f26ahr 1062 17 . . . cord-028721-x6f26ahr 1063 1 There there EX cord-028721-x6f26ahr 1063 2 are be VBP cord-028721-x6f26ahr 1063 3 scant scant JJ cord-028721-x6f26ahr 1063 4 spermatogonia spermatogonia NN cord-028721-x6f26ahr 1063 5 that that WDT cord-028721-x6f26ahr 1063 6 fail fail VBP cord-028721-x6f26ahr 1063 7 to to TO cord-028721-x6f26ahr 1063 8 display display VB cord-028721-x6f26ahr 1063 9 signs sign NNS cord-028721-x6f26ahr 1063 10 of of IN cord-028721-x6f26ahr 1063 11 maturation maturation NN cord-028721-x6f26ahr 1063 12 or or CC cord-028721-x6f26ahr 1063 13 proliferation proliferation NN cord-028721-x6f26ahr 1063 14 . . . cord-028721-x6f26ahr 1064 1 Also also RB cord-028721-x6f26ahr 1064 2 , , , cord-028721-x6f26ahr 1064 3 some some DT cord-028721-x6f26ahr 1064 4 of of IN cord-028721-x6f26ahr 1064 5 the the DT cord-028721-x6f26ahr 1064 6 tubules tubule NNS cord-028721-x6f26ahr 1064 7 contain contain VBP cord-028721-x6f26ahr 1064 8 intratubular intratubular JJ cord-028721-x6f26ahr 1064 9 undifferentiated undifferentiated JJ cord-028721-x6f26ahr 1064 10 germ germ NN cord-028721-x6f26ahr 1064 11 cell cell NN cord-028721-x6f26ahr 1064 12 neoplasia neoplasia NN cord-028721-x6f26ahr 1064 13 that that WDT cord-028721-x6f26ahr 1064 14 usually usually RB cord-028721-x6f26ahr 1064 15 also also RB cord-028721-x6f26ahr 1064 16 appears appear VBZ cord-028721-x6f26ahr 1064 17 in in IN cord-028721-x6f26ahr 1064 18 the the DT cord-028721-x6f26ahr 1064 19 adjacent adjacent JJ cord-028721-x6f26ahr 1064 20 , , , cord-028721-x6f26ahr 1064 21 non non JJ cord-028721-x6f26ahr 1064 22 - - JJ cord-028721-x6f26ahr 1064 23 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1064 24 seminiferous seminiferous JJ cord-028721-x6f26ahr 1064 25 tubules tubule NNS cord-028721-x6f26ahr 1064 26 . . . cord-028721-x6f26ahr 1065 1 The the DT cord-028721-x6f26ahr 1065 2 histologic histologic JJ cord-028721-x6f26ahr 1065 3 picture picture NN cord-028721-x6f26ahr 1065 4 is be VBZ cord-028721-x6f26ahr 1065 5 similar similar JJ cord-028721-x6f26ahr 1065 6 to to IN cord-028721-x6f26ahr 1065 7 that that DT cord-028721-x6f26ahr 1065 8 of of IN cord-028721-x6f26ahr 1065 9 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1065 10 , , , cord-028721-x6f26ahr 1065 11 but but CC cord-028721-x6f26ahr 1065 12 such such PDT cord-028721-x6f26ahr 1065 13 a a DT cord-028721-x6f26ahr 1065 14 tumor tumor NN cord-028721-x6f26ahr 1065 15 can can MD cord-028721-x6f26ahr 1065 16 be be VB cord-028721-x6f26ahr 1065 17 easily easily RB cord-028721-x6f26ahr 1065 18 excluded exclude VBN cord-028721-x6f26ahr 1065 19 because because IN cord-028721-x6f26ahr 1065 20 it -PRON- PRP cord-028721-x6f26ahr 1065 21 arises arise VBZ cord-028721-x6f26ahr 1065 22 in in IN cord-028721-x6f26ahr 1065 23 malformed malformed JJ cord-028721-x6f26ahr 1065 24 gonads gonad NNS cord-028721-x6f26ahr 1065 25 ( ( -LRB- cord-028721-x6f26ahr 1065 26 gonadal gonadal JJ cord-028721-x6f26ahr 1065 27 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1065 28 and and CC cord-028721-x6f26ahr 1065 29 testicular testicular NNP cord-028721-x6f26ahr 1065 30 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 1065 31 ) ) -RRB- cord-028721-x6f26ahr 1065 32 characteristic characteristic NN cord-028721-x6f26ahr 1065 33 of of IN cord-028721-x6f26ahr 1065 34 intersex intersex NN cord-028721-x6f26ahr 1065 35 stages stage NNS cord-028721-x6f26ahr 1065 36 , , , cord-028721-x6f26ahr 1065 37 unlike unlike IN cord-028721-x6f26ahr 1065 38 patients patient NNS cord-028721-x6f26ahr 1065 39 with with IN cord-028721-x6f26ahr 1065 40 tubular tubular JJ cord-028721-x6f26ahr 1065 41 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1065 42 . . . cord-028721-x6f26ahr 1066 1 Congenital Congenital NNP cord-028721-x6f26ahr 1066 2 testicular testicular NNP cord-028721-x6f26ahr 1066 3 lymphangiectasis lymphangiectasis NNP cord-028721-x6f26ahr 1066 4 is be VBZ cord-028721-x6f26ahr 1066 5 characterized characterize VBN cord-028721-x6f26ahr 1066 6 by by IN cord-028721-x6f26ahr 1066 7 abnormal abnormal JJ cord-028721-x6f26ahr 1066 8 and and CC cord-028721-x6f26ahr 1066 9 excessive excessive JJ cord-028721-x6f26ahr 1066 10 development development NN cord-028721-x6f26ahr 1066 11 of of IN cord-028721-x6f26ahr 1066 12 lymphatic lymphatic JJ cord-028721-x6f26ahr 1066 13 vessels vessel NNS cord-028721-x6f26ahr 1066 14 in in IN cord-028721-x6f26ahr 1066 15 the the DT cord-028721-x6f26ahr 1066 16 tunica tunica NNP cord-028721-x6f26ahr 1066 17 albuginea albuginea NNP cord-028721-x6f26ahr 1066 18 , , , cord-028721-x6f26ahr 1066 19 mediastinum mediastinum FW cord-028721-x6f26ahr 1066 20 testis testis NN cord-028721-x6f26ahr 1066 21 , , , cord-028721-x6f26ahr 1066 22 interlobular interlobular NNP cord-028721-x6f26ahr 1066 23 septa septa NNP cord-028721-x6f26ahr 1066 24 , , , cord-028721-x6f26ahr 1066 25 and and CC cord-028721-x6f26ahr 1066 26 testicular testicular NNP cord-028721-x6f26ahr 1066 27 interstitium interstitium NN cord-028721-x6f26ahr 1066 28 . . . cord-028721-x6f26ahr 1067 1 [ [ -LRB- cord-028721-x6f26ahr 1067 2 461 461 CD cord-028721-x6f26ahr 1067 3 ] ] -RRB- cord-028721-x6f26ahr 1067 4 [ [ -LRB- cord-028721-x6f26ahr 1067 5 462 462 CD cord-028721-x6f26ahr 1067 6 ] ] -RRB- cord-028721-x6f26ahr 1067 7 [ [ -LRB- cord-028721-x6f26ahr 1067 8 463 463 CD cord-028721-x6f26ahr 1067 9 ] ] -RRB- cord-028721-x6f26ahr 1068 1 Ultrastructurally Ultrastructurally NNP cord-028721-x6f26ahr 1068 2 these these DT cord-028721-x6f26ahr 1068 3 dilated dilated JJ cord-028721-x6f26ahr 1068 4 vessels vessel NNS cord-028721-x6f26ahr 1068 5 are be VBP cord-028721-x6f26ahr 1068 6 similar similar JJ cord-028721-x6f26ahr 1068 7 to to IN cord-028721-x6f26ahr 1068 8 normal normal JJ cord-028721-x6f26ahr 1068 9 lymphatic lymphatic JJ cord-028721-x6f26ahr 1068 10 capillaries capillary NNS cord-028721-x6f26ahr 1068 11 , , , cord-028721-x6f26ahr 1068 12 although although IN cord-028721-x6f26ahr 1068 13 some some DT cord-028721-x6f26ahr 1068 14 are be VBP cord-028721-x6f26ahr 1068 15 markedly markedly RB cord-028721-x6f26ahr 1068 16 dilated dilated JJ cord-028721-x6f26ahr 1068 17 and and CC cord-028721-x6f26ahr 1068 18 the the DT cord-028721-x6f26ahr 1068 19 testicular testicular JJ cord-028721-x6f26ahr 1068 20 interstitium interstitium NN cord-028721-x6f26ahr 1068 21 is be VBZ cord-028721-x6f26ahr 1068 22 slightly slightly RB cord-028721-x6f26ahr 1068 23 edematous edematous JJ cord-028721-x6f26ahr 1068 24 ( ( -LRB- cord-028721-x6f26ahr 1068 25 Fig fig NN cord-028721-x6f26ahr 1068 26 . . . cord-028721-x6f26ahr 1068 27 12 12 CD cord-028721-x6f26ahr 1068 28 - - SYM cord-028721-x6f26ahr 1068 29 42 42 CD cord-028721-x6f26ahr 1068 30 ) ) -RRB- cord-028721-x6f26ahr 1068 31 . . . cord-028721-x6f26ahr 1069 1 Testicular testicular JJ cord-028721-x6f26ahr 1069 2 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 1069 3 occurs occur VBZ cord-028721-x6f26ahr 1069 4 in in IN cord-028721-x6f26ahr 1069 5 both both CC cord-028721-x6f26ahr 1069 6 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1069 7 and and CC cord-028721-x6f26ahr 1069 8 scrotal scrotal JJ cord-028721-x6f26ahr 1069 9 testes testis NNS cord-028721-x6f26ahr 1069 10 ; ; : cord-028721-x6f26ahr 1069 11 in in IN cord-028721-x6f26ahr 1069 12 one one CD cord-028721-x6f26ahr 1069 13 of of IN cord-028721-x6f26ahr 1069 14 the the DT cord-028721-x6f26ahr 1069 15 latter latter JJ cord-028721-x6f26ahr 1069 16 cases case NNS cord-028721-x6f26ahr 1069 17 , , , cord-028721-x6f26ahr 1069 18 the the DT cord-028721-x6f26ahr 1069 19 patient patient NN cord-028721-x6f26ahr 1069 20 had have VBD cord-028721-x6f26ahr 1069 21 Noonan Noonan NNP cord-028721-x6f26ahr 1069 22 's 's POS cord-028721-x6f26ahr 1069 23 syndrome syndrome NN cord-028721-x6f26ahr 1069 24 . . . cord-028721-x6f26ahr 1070 1 The the DT cord-028721-x6f26ahr 1070 2 disease disease NN cord-028721-x6f26ahr 1070 3 does do VBZ cord-028721-x6f26ahr 1070 4 not not RB cord-028721-x6f26ahr 1070 5 seem seem VB cord-028721-x6f26ahr 1070 6 to to TO cord-028721-x6f26ahr 1070 7 affect affect VB cord-028721-x6f26ahr 1070 8 the the DT cord-028721-x6f26ahr 1070 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 1070 10 tubules tubule NNS cord-028721-x6f26ahr 1070 11 , , , cord-028721-x6f26ahr 1070 12 and and CC cord-028721-x6f26ahr 1070 13 low low JJ cord-028721-x6f26ahr 1070 14 numbers number NNS cord-028721-x6f26ahr 1070 15 of of IN cord-028721-x6f26ahr 1070 16 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1070 17 and and CC cord-028721-x6f26ahr 1070 18 reduced reduce VBN cord-028721-x6f26ahr 1070 19 tubular tubular JJ cord-028721-x6f26ahr 1070 20 diameters diameter NNS cord-028721-x6f26ahr 1070 21 are be VBP cord-028721-x6f26ahr 1070 22 observed observe VBN cord-028721-x6f26ahr 1070 23 only only RB cord-028721-x6f26ahr 1070 24 in in IN cord-028721-x6f26ahr 1070 25 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1070 26 testes testis NNS cord-028721-x6f26ahr 1070 27 . . . cord-028721-x6f26ahr 1071 1 The the DT cord-028721-x6f26ahr 1071 2 epididymis epididymis NN cord-028721-x6f26ahr 1071 3 and and CC cord-028721-x6f26ahr 1071 4 spermatic spermatic JJ cord-028721-x6f26ahr 1071 5 cord cord NN cord-028721-x6f26ahr 1071 6 are be VBP cord-028721-x6f26ahr 1071 7 not not RB cord-028721-x6f26ahr 1071 8 affected affect VBN cord-028721-x6f26ahr 1071 9 , , , cord-028721-x6f26ahr 1071 10 and and CC cord-028721-x6f26ahr 1071 11 congenital congenital JJ cord-028721-x6f26ahr 1071 12 testicular testicular NNP cord-028721-x6f26ahr 1071 13 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 1071 14 is be VBZ cord-028721-x6f26ahr 1071 15 not not RB cord-028721-x6f26ahr 1071 16 associated associate VBN cord-028721-x6f26ahr 1071 17 with with IN cord-028721-x6f26ahr 1071 18 pulmonary pulmonary JJ cord-028721-x6f26ahr 1071 19 , , , cord-028721-x6f26ahr 1071 20 intestinal intestinal JJ cord-028721-x6f26ahr 1071 21 , , , cord-028721-x6f26ahr 1071 22 or or CC cord-028721-x6f26ahr 1071 23 systemic systemic JJ cord-028721-x6f26ahr 1071 24 lymphangiectasis lymphangiectasi NNS cord-028721-x6f26ahr 1071 25 . . . cord-028721-x6f26ahr 1072 1 During during IN cord-028721-x6f26ahr 1072 2 fetal fetal JJ cord-028721-x6f26ahr 1072 3 life life NN cord-028721-x6f26ahr 1072 4 , , , cord-028721-x6f26ahr 1072 5 lymphatic lymphatic JJ cord-028721-x6f26ahr 1072 6 vessels vessel NNS cord-028721-x6f26ahr 1072 7 are be VBP cord-028721-x6f26ahr 1072 8 visible visible JJ cord-028721-x6f26ahr 1072 9 only only RB cord-028721-x6f26ahr 1072 10 immediately immediately RB cord-028721-x6f26ahr 1072 11 beneath beneath IN cord-028721-x6f26ahr 1072 12 the the DT cord-028721-x6f26ahr 1072 13 tunica tunica NNP cord-028721-x6f26ahr 1072 14 albuginea albuginea NNP cord-028721-x6f26ahr 1072 15 and and CC cord-028721-x6f26ahr 1072 16 in in IN cord-028721-x6f26ahr 1072 17 the the DT cord-028721-x6f26ahr 1072 18 interlobular interlobular JJ cord-028721-x6f26ahr 1072 19 septa septa NNP cord-028721-x6f26ahr 1072 20 . . . cord-028721-x6f26ahr 1073 1 464 464 CD cord-028721-x6f26ahr 1074 1 During during IN cord-028721-x6f26ahr 1074 2 childhood childhood NN cord-028721-x6f26ahr 1074 3 , , , cord-028721-x6f26ahr 1074 4 the the DT cord-028721-x6f26ahr 1074 5 number number NN cord-028721-x6f26ahr 1074 6 and and CC cord-028721-x6f26ahr 1074 7 size size NN cord-028721-x6f26ahr 1074 8 of of IN cord-028721-x6f26ahr 1074 9 the the DT cord-028721-x6f26ahr 1074 10 septal septal JJ cord-028721-x6f26ahr 1074 11 lymphatic lymphatic JJ cord-028721-x6f26ahr 1074 12 vessels vessel NNS cord-028721-x6f26ahr 1074 13 decreases decrease VBZ cord-028721-x6f26ahr 1074 14 ; ; : cord-028721-x6f26ahr 1074 15 465 465 CD cord-028721-x6f26ahr 1074 16 by by IN cord-028721-x6f26ahr 1074 17 adulthood adulthood NN cord-028721-x6f26ahr 1074 18 they -PRON- PRP cord-028721-x6f26ahr 1074 19 are be VBP cord-028721-x6f26ahr 1074 20 inconspicuous inconspicuous JJ cord-028721-x6f26ahr 1074 21 . . . cord-028721-x6f26ahr 1075 1 466 466 CD cord-028721-x6f26ahr 1076 1 In in IN cord-028721-x6f26ahr 1076 2 lymphangiectasis lymphangiectasi NNS cord-028721-x6f26ahr 1076 3 , , , cord-028721-x6f26ahr 1076 4 the the DT cord-028721-x6f26ahr 1076 5 septal septal JJ cord-028721-x6f26ahr 1076 6 lymphatic lymphatic JJ cord-028721-x6f26ahr 1076 7 vessels vessel NNS cord-028721-x6f26ahr 1076 8 are be VBP cord-028721-x6f26ahr 1076 9 large large JJ cord-028721-x6f26ahr 1076 10 and and CC cord-028721-x6f26ahr 1076 11 often often RB cord-028721-x6f26ahr 1076 12 massively massively RB cord-028721-x6f26ahr 1076 13 dilated dilated JJ cord-028721-x6f26ahr 1076 14 . . . cord-028721-x6f26ahr 1077 1 Testicular testicular JJ cord-028721-x6f26ahr 1077 2 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 1077 3 occurs occur VBZ cord-028721-x6f26ahr 1077 4 only only RB cord-028721-x6f26ahr 1077 5 in in IN cord-028721-x6f26ahr 1077 6 the the DT cord-028721-x6f26ahr 1077 7 childhood childhood NN cord-028721-x6f26ahr 1077 8 testis testis NN cord-028721-x6f26ahr 1077 9 , , , cord-028721-x6f26ahr 1077 10 suggesting suggest VBG cord-028721-x6f26ahr 1077 11 that that IN cord-028721-x6f26ahr 1077 12 these these DT cord-028721-x6f26ahr 1077 13 dilated dilated JJ cord-028721-x6f26ahr 1077 14 vessels vessel NNS cord-028721-x6f26ahr 1077 15 undergo undergo VBP cord-028721-x6f26ahr 1077 16 involution involution NN cord-028721-x6f26ahr 1077 17 at at IN cord-028721-x6f26ahr 1077 18 puberty puberty NN cord-028721-x6f26ahr 1077 19 or or CC cord-028721-x6f26ahr 1077 20 that that IN cord-028721-x6f26ahr 1077 21 pubertal pubertal JJ cord-028721-x6f26ahr 1077 22 development development NN cord-028721-x6f26ahr 1077 23 of of IN cord-028721-x6f26ahr 1077 24 the the DT cord-028721-x6f26ahr 1077 25 seminiferous seminiferous JJ cord-028721-x6f26ahr 1077 26 tubules tubule NNS cord-028721-x6f26ahr 1077 27 masks mask VBZ cord-028721-x6f26ahr 1077 28 the the DT cord-028721-x6f26ahr 1077 29 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 1077 30 . . . cord-028721-x6f26ahr 1078 1 One one CD cord-028721-x6f26ahr 1078 2 exceptional exceptional JJ cord-028721-x6f26ahr 1078 3 case case NN cord-028721-x6f26ahr 1078 4 of of IN cord-028721-x6f26ahr 1078 5 epididymal epididymal JJ cord-028721-x6f26ahr 1078 6 lymphangiectasis lymphangiectasis NNP cord-028721-x6f26ahr 1078 7 , , , cord-028721-x6f26ahr 1078 8 with with IN cord-028721-x6f26ahr 1078 9 dilated dilated JJ cord-028721-x6f26ahr 1078 10 epididymal epididymal JJ cord-028721-x6f26ahr 1078 11 blood blood NN cord-028721-x6f26ahr 1078 12 vessels vessel NNS cord-028721-x6f26ahr 1078 13 , , , cord-028721-x6f26ahr 1078 14 was be VBD cord-028721-x6f26ahr 1078 15 reported report VBN cord-028721-x6f26ahr 1078 16 in in IN cord-028721-x6f26ahr 1078 17 a a DT cord-028721-x6f26ahr 1078 18 59-year 59-year JJ cord-028721-x6f26ahr 1078 19 - - HYPH cord-028721-x6f26ahr 1078 20 old old JJ cord-028721-x6f26ahr 1078 21 man man NN cord-028721-x6f26ahr 1078 22 . . . cord-028721-x6f26ahr 1079 1 467 467 CD cord-028721-x6f26ahr 1080 1 The the DT cord-028721-x6f26ahr 1080 2 vessels vessel NNS cord-028721-x6f26ahr 1080 3 distort distort VBP cord-028721-x6f26ahr 1080 4 the the DT cord-028721-x6f26ahr 1080 5 architecture architecture NN cord-028721-x6f26ahr 1080 6 of of IN cord-028721-x6f26ahr 1080 7 the the DT cord-028721-x6f26ahr 1080 8 ductuli ductuli NNP cord-028721-x6f26ahr 1080 9 efferentes efferentes NNP cord-028721-x6f26ahr 1080 10 , , , cord-028721-x6f26ahr 1080 11 which which WDT cord-028721-x6f26ahr 1080 12 in in IN cord-028721-x6f26ahr 1080 13 turn turn NN cord-028721-x6f26ahr 1080 14 become become VBP cord-028721-x6f26ahr 1080 15 irregularly irregularly RB cord-028721-x6f26ahr 1080 16 dilated dilate VBN cord-028721-x6f26ahr 1080 17 by by IN cord-028721-x6f26ahr 1080 18 mechanical mechanical JJ cord-028721-x6f26ahr 1080 19 compression compression NN cord-028721-x6f26ahr 1080 20 . . . cord-028721-x6f26ahr 1081 1 Other other JJ cord-028721-x6f26ahr 1081 2 hamartomas hamartomas NN cord-028721-x6f26ahr 1081 3 of of IN cord-028721-x6f26ahr 1081 4 the the DT cord-028721-x6f26ahr 1081 5 testis testis NN cord-028721-x6f26ahr 1081 6 include include VBP cord-028721-x6f26ahr 1081 7 hamartoma hamartoma NN cord-028721-x6f26ahr 1081 8 of of IN cord-028721-x6f26ahr 1081 9 the the DT cord-028721-x6f26ahr 1081 10 rete rete NNP cord-028721-x6f26ahr 1081 11 testis testis NN cord-028721-x6f26ahr 1081 12 and and CC cord-028721-x6f26ahr 1081 13 smooth smooth JJ cord-028721-x6f26ahr 1081 14 muscle muscle NN cord-028721-x6f26ahr 1081 15 hamartoma hamartoma NN cord-028721-x6f26ahr 1081 16 . . . cord-028721-x6f26ahr 1082 1 Hamartoma Hamartoma NNP cord-028721-x6f26ahr 1082 2 of of IN cord-028721-x6f26ahr 1082 3 the the DT cord-028721-x6f26ahr 1082 4 rete rete NN cord-028721-x6f26ahr 1082 5 testis testis NN cord-028721-x6f26ahr 1082 6 is be VBZ cord-028721-x6f26ahr 1082 7 a a DT cord-028721-x6f26ahr 1082 8 disordered disordered JJ cord-028721-x6f26ahr 1082 9 proliferation proliferation NN cord-028721-x6f26ahr 1082 10 of of IN cord-028721-x6f26ahr 1082 11 tubular tubular JJ cord-028721-x6f26ahr 1082 12 structures structure NNS cord-028721-x6f26ahr 1082 13 in in IN cord-028721-x6f26ahr 1082 14 a a DT cord-028721-x6f26ahr 1082 15 loose loose JJ cord-028721-x6f26ahr 1082 16 connective connective JJ cord-028721-x6f26ahr 1082 17 tissue tissue NN cord-028721-x6f26ahr 1082 18 . . . cord-028721-x6f26ahr 1083 1 468 468 CD cord-028721-x6f26ahr 1083 2 Cystic cystic JJ cord-028721-x6f26ahr 1083 3 transformation transformation NN cord-028721-x6f26ahr 1083 4 of of IN cord-028721-x6f26ahr 1083 5 the the DT cord-028721-x6f26ahr 1083 6 rete rete NN cord-028721-x6f26ahr 1083 7 testis testis NN cord-028721-x6f26ahr 1083 8 associated associate VBN cord-028721-x6f26ahr 1083 9 with with IN cord-028721-x6f26ahr 1083 10 proliferation proliferation NN cord-028721-x6f26ahr 1083 11 of of IN cord-028721-x6f26ahr 1083 12 smooth smooth JJ cord-028721-x6f26ahr 1083 13 muscle muscle NN cord-028721-x6f26ahr 1083 14 cells cell NNS cord-028721-x6f26ahr 1083 15 and and CC cord-028721-x6f26ahr 1083 16 abundant abundant JJ cord-028721-x6f26ahr 1083 17 myxoid myxoid NN cord-028721-x6f26ahr 1083 18 stroma stroma NN cord-028721-x6f26ahr 1083 19 was be VBD cord-028721-x6f26ahr 1083 20 reported report VBN cord-028721-x6f26ahr 1083 21 in in IN cord-028721-x6f26ahr 1083 22 a a DT cord-028721-x6f26ahr 1083 23 26-year 26-year JJ cord-028721-x6f26ahr 1083 24 - - HYPH cord-028721-x6f26ahr 1083 25 old old JJ cord-028721-x6f26ahr 1083 26 man man NN cord-028721-x6f26ahr 1083 27 . . . cord-028721-x6f26ahr 1084 1 469 469 CD cord-028721-x6f26ahr 1084 2 Smooth smooth JJ cord-028721-x6f26ahr 1084 3 muscle muscle NN cord-028721-x6f26ahr 1084 4 hamartoma hamartoma NN cord-028721-x6f26ahr 1084 5 is be VBZ cord-028721-x6f26ahr 1084 6 located locate VBN cord-028721-x6f26ahr 1084 7 in in IN cord-028721-x6f26ahr 1084 8 the the DT cord-028721-x6f26ahr 1084 9 inferior inferior JJ cord-028721-x6f26ahr 1084 10 testicular testicular NNP cord-028721-x6f26ahr 1084 11 pole pole NN cord-028721-x6f26ahr 1084 12 , , , cord-028721-x6f26ahr 1084 13 the the DT cord-028721-x6f26ahr 1084 14 cauda cauda NN cord-028721-x6f26ahr 1084 15 of of IN cord-028721-x6f26ahr 1084 16 the the DT cord-028721-x6f26ahr 1084 17 epididymis epididymis NN cord-028721-x6f26ahr 1084 18 , , , cord-028721-x6f26ahr 1084 19 and and CC cord-028721-x6f26ahr 1084 20 the the DT cord-028721-x6f26ahr 1084 21 proximal proximal JJ cord-028721-x6f26ahr 1084 22 segment segment NN cord-028721-x6f26ahr 1084 23 of of IN cord-028721-x6f26ahr 1084 24 the the DT cord-028721-x6f26ahr 1084 25 vas vas FW cord-028721-x6f26ahr 1084 26 deferens deferen NNS cord-028721-x6f26ahr 1084 27 ( ( -LRB- cord-028721-x6f26ahr 1084 28 Fig Fig NNP cord-028721-x6f26ahr 1084 29 . . . cord-028721-x6f26ahr 1084 30 12 12 CD cord-028721-x6f26ahr 1084 31 - - SYM cord-028721-x6f26ahr 1084 32 43 43 CD cord-028721-x6f26ahr 1084 33 ) ) -RRB- cord-028721-x6f26ahr 1084 34 , , , cord-028721-x6f26ahr 1084 35 470 470 CD cord-028721-x6f26ahr 1084 36 and and CC cord-028721-x6f26ahr 1084 37 is be VBZ cord-028721-x6f26ahr 1084 38 similar similar JJ cord-028721-x6f26ahr 1084 39 to to IN cord-028721-x6f26ahr 1084 40 that that DT cord-028721-x6f26ahr 1084 41 reported report VBN cord-028721-x6f26ahr 1084 42 in in IN cord-028721-x6f26ahr 1084 43 the the DT cord-028721-x6f26ahr 1084 44 digestive digestive JJ cord-028721-x6f26ahr 1084 45 and and CC cord-028721-x6f26ahr 1084 46 respiratory respiratory JJ cord-028721-x6f26ahr 1084 47 tracts tract NNS cord-028721-x6f26ahr 1084 48 . . . cord-028721-x6f26ahr 1085 1 471 471 CD cord-028721-x6f26ahr 1085 2 , , , cord-028721-x6f26ahr 1085 3 472 472 CD cord-028721-x6f26ahr 1085 4 Smooth smooth JJ cord-028721-x6f26ahr 1085 5 muscle muscle NN cord-028721-x6f26ahr 1085 6 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1085 7 also also RB cord-028721-x6f26ahr 1085 8 occurs occur VBZ cord-028721-x6f26ahr 1085 9 in in IN cord-028721-x6f26ahr 1085 10 the the DT cord-028721-x6f26ahr 1085 11 androgen androgen NN cord-028721-x6f26ahr 1085 12 insensitivity insensitivity NN cord-028721-x6f26ahr 1085 13 syndrome syndrome NN cord-028721-x6f26ahr 1085 14 , , , cord-028721-x6f26ahr 1085 15 forming form VBG cord-028721-x6f26ahr 1085 16 nodules nodule NNS cord-028721-x6f26ahr 1085 17 up up IN cord-028721-x6f26ahr 1085 18 to to IN cord-028721-x6f26ahr 1085 19 1 1 CD cord-028721-x6f26ahr 1085 20 cm cm NNS cord-028721-x6f26ahr 1085 21 in in IN cord-028721-x6f26ahr 1085 22 diameter diameter NN cord-028721-x6f26ahr 1085 23 . . . cord-028721-x6f26ahr 1086 1 The the DT cord-028721-x6f26ahr 1086 2 muscular muscular JJ cord-028721-x6f26ahr 1086 3 proliferation proliferation NN cord-028721-x6f26ahr 1086 4 is be VBZ cord-028721-x6f26ahr 1086 5 located locate VBN cord-028721-x6f26ahr 1086 6 in in IN cord-028721-x6f26ahr 1086 7 the the DT cord-028721-x6f26ahr 1086 8 lower low JJR cord-028721-x6f26ahr 1086 9 testicular testicular JJ cord-028721-x6f26ahr 1086 10 pole pole NN cord-028721-x6f26ahr 1086 11 , , , cord-028721-x6f26ahr 1086 12 and and CC cord-028721-x6f26ahr 1086 13 involves involve VBZ cord-028721-x6f26ahr 1086 14 the the DT cord-028721-x6f26ahr 1086 15 tunica tunica NNP cord-028721-x6f26ahr 1086 16 albuginea albuginea NNP cord-028721-x6f26ahr 1086 17 and and CC cord-028721-x6f26ahr 1086 18 adjacent adjacent JJ cord-028721-x6f26ahr 1086 19 soft soft JJ cord-028721-x6f26ahr 1086 20 tissues tissue NNS cord-028721-x6f26ahr 1086 21 . . . cord-028721-x6f26ahr 1087 1 This this DT cord-028721-x6f26ahr 1087 2 infrequent infrequent JJ cord-028721-x6f26ahr 1087 3 fi fi NN cord-028721-x6f26ahr 1087 4 nding nding NN cord-028721-x6f26ahr 1087 5 has have VBZ cord-028721-x6f26ahr 1087 6 been be VBN cord-028721-x6f26ahr 1087 7 observed observe VBN cord-028721-x6f26ahr 1087 8 in in IN cord-028721-x6f26ahr 1087 9 newborns newborn NNS cord-028721-x6f26ahr 1087 10 and and CC cord-028721-x6f26ahr 1087 11 consists consist VBZ cord-028721-x6f26ahr 1087 12 of of IN cord-028721-x6f26ahr 1087 13 gonadal gonadal JJ cord-028721-x6f26ahr 1087 14 blastema blastema NNP cord-028721-x6f26ahr 1087 15 in in IN cord-028721-x6f26ahr 1087 16 otherwise otherwise RB cord-028721-x6f26ahr 1087 17 normal normal JJ cord-028721-x6f26ahr 1087 18 testes testis NNS cord-028721-x6f26ahr 1087 19 . . . cord-028721-x6f26ahr 1088 1 The the DT cord-028721-x6f26ahr 1088 2 blastema blastema NNP cord-028721-x6f26ahr 1088 3 is be VBZ cord-028721-x6f26ahr 1088 4 located locate VBN cord-028721-x6f26ahr 1088 5 in in IN cord-028721-x6f26ahr 1088 6 the the DT cord-028721-x6f26ahr 1088 7 vicinity vicinity NN cord-028721-x6f26ahr 1088 8 of of IN cord-028721-x6f26ahr 1088 9 the the DT cord-028721-x6f26ahr 1088 10 upper upper JJ cord-028721-x6f26ahr 1088 11 testicular testicular NNP cord-028721-x6f26ahr 1088 12 pole pole NN cord-028721-x6f26ahr 1088 13 , , , cord-028721-x6f26ahr 1088 14 near near IN cord-028721-x6f26ahr 1088 15 the the DT cord-028721-x6f26ahr 1088 16 implantation implantation NN cord-028721-x6f26ahr 1088 17 of of IN cord-028721-x6f26ahr 1088 18 the the DT cord-028721-x6f26ahr 1088 19 caput caput NN cord-028721-x6f26ahr 1088 20 of of IN cord-028721-x6f26ahr 1088 21 the the DT cord-028721-x6f26ahr 1088 22 epididymis epididymis NN cord-028721-x6f26ahr 1088 23 , , , cord-028721-x6f26ahr 1088 24 displays display VBZ cord-028721-x6f26ahr 1088 25 a a DT cord-028721-x6f26ahr 1088 26 crescent crescent NN cord-028721-x6f26ahr 1088 27 shape shape NN cord-028721-x6f26ahr 1088 28 , , , cord-028721-x6f26ahr 1088 29 and and CC cord-028721-x6f26ahr 1088 30 extends extend VBZ cord-028721-x6f26ahr 1088 31 throughout throughout IN cord-028721-x6f26ahr 1088 32 the the DT cord-028721-x6f26ahr 1088 33 depth depth NN cord-028721-x6f26ahr 1088 34 of of IN cord-028721-x6f26ahr 1088 35 the the DT cord-028721-x6f26ahr 1088 36 tunica tunica NNP cord-028721-x6f26ahr 1088 37 albuginea albuginea NNP cord-028721-x6f26ahr 1088 38 and and CC cord-028721-x6f26ahr 1088 39 the the DT cord-028721-x6f26ahr 1088 40 adjacent adjacent JJ cord-028721-x6f26ahr 1088 41 testicular testicular JJ cord-028721-x6f26ahr 1088 42 parenchyma parenchyma NN cord-028721-x6f26ahr 1088 43 . . . cord-028721-x6f26ahr 1089 1 The the DT cord-028721-x6f26ahr 1089 2 blastema blastema NN cord-028721-x6f26ahr 1089 3 consists consist VBZ cord-028721-x6f26ahr 1089 4 of of IN cord-028721-x6f26ahr 1089 5 epithelial epithelial JJ cord-028721-x6f26ahr 1089 6 cords cord NNS cord-028721-x6f26ahr 1089 7 of of IN cord-028721-x6f26ahr 1089 8 cells cell NNS cord-028721-x6f26ahr 1089 9 or or CC cord-028721-x6f26ahr 1089 10 solid solid JJ cord-028721-x6f26ahr 1089 11 masses masse NNS cord-028721-x6f26ahr 1089 12 in in IN cord-028721-x6f26ahr 1089 13 continuity continuity NN cord-028721-x6f26ahr 1089 14 with with IN cord-028721-x6f26ahr 1089 15 the the DT cord-028721-x6f26ahr 1089 16 mesothelium mesothelium NN cord-028721-x6f26ahr 1090 1 ( ( -LRB- cord-028721-x6f26ahr 1090 2 Fig Fig NNP cord-028721-x6f26ahr 1090 3 . . . cord-028721-x6f26ahr 1090 4 12 12 CD cord-028721-x6f26ahr 1090 5 - - SYM cord-028721-x6f26ahr 1090 6 44 44 CD cord-028721-x6f26ahr 1090 7 ) ) -RRB- cord-028721-x6f26ahr 1090 8 . . . cord-028721-x6f26ahr 1091 1 These these DT cord-028721-x6f26ahr 1091 2 cells cell NNS cord-028721-x6f26ahr 1091 3 are be VBP cord-028721-x6f26ahr 1091 4 intermingled intermingle VBN cord-028721-x6f26ahr 1091 5 with with IN cord-028721-x6f26ahr 1091 6 others other NNS cord-028721-x6f26ahr 1091 7 that that WDT cord-028721-x6f26ahr 1091 8 are be VBP cord-028721-x6f26ahr 1091 9 larger large JJR cord-028721-x6f26ahr 1091 10 , , , cord-028721-x6f26ahr 1091 11 with with IN cord-028721-x6f26ahr 1091 12 pale pale JJ cord-028721-x6f26ahr 1091 13 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1091 14 , , , cord-028721-x6f26ahr 1091 15 vesicular vesicular JJ cord-028721-x6f26ahr 1091 16 nuclei nucleus NNS cord-028721-x6f26ahr 1091 17 , , , cord-028721-x6f26ahr 1091 18 and and CC cord-028721-x6f26ahr 1091 19 prominent prominent JJ cord-028721-x6f26ahr 1091 20 nucleoli nucleolus NNS cord-028721-x6f26ahr 1091 21 . . . cord-028721-x6f26ahr 1092 1 The the DT cord-028721-x6f26ahr 1092 2 blastematous blastematous JJ cord-028721-x6f26ahr 1092 3 epithelial epithelial JJ cord-028721-x6f26ahr 1092 4 cells cell NNS cord-028721-x6f26ahr 1092 5 display display VBP cord-028721-x6f26ahr 1092 6 immunoreactivity immunoreactivity NN cord-028721-x6f26ahr 1092 7 for for IN cord-028721-x6f26ahr 1092 8 vimentin vimentin NNS cord-028721-x6f26ahr 1092 9 , , , cord-028721-x6f26ahr 1092 10 laminin laminin NN cord-028721-x6f26ahr 1092 11 , , , cord-028721-x6f26ahr 1092 12 type type NN cord-028721-x6f26ahr 1092 13 IV IV NNP cord-028721-x6f26ahr 1092 14 collagen collagen NN cord-028721-x6f26ahr 1092 15 , , , cord-028721-x6f26ahr 1092 16 and and CC cord-028721-x6f26ahr 1092 17 cytokeratin cytokeratin NNP cord-028721-x6f26ahr 1092 18 ; ; : cord-028721-x6f26ahr 1092 19 the the DT cord-028721-x6f26ahr 1092 20 expression expression NN cord-028721-x6f26ahr 1092 21 of of IN cord-028721-x6f26ahr 1092 22 the the DT cord-028721-x6f26ahr 1092 23 latter latter JJ cord-028721-x6f26ahr 1092 24 in in IN cord-028721-x6f26ahr 1092 25 the the DT cord-028721-x6f26ahr 1092 26 most most JJS cord-028721-x6f26ahr 1092 27 superfi superfi NNS cord-028721-x6f26ahr 1092 28 cial cial JJ cord-028721-x6f26ahr 1092 29 cells cell NNS cord-028721-x6f26ahr 1092 30 is be VBZ cord-028721-x6f26ahr 1092 31 similar similar JJ cord-028721-x6f26ahr 1092 32 to to IN cord-028721-x6f26ahr 1092 33 that that DT cord-028721-x6f26ahr 1092 34 of of IN cord-028721-x6f26ahr 1092 35 mesothelial mesothelial JJ cord-028721-x6f26ahr 1092 36 cells cell NNS cord-028721-x6f26ahr 1092 37 and and CC cord-028721-x6f26ahr 1092 38 decreases decrease NNS cord-028721-x6f26ahr 1092 39 in in IN cord-028721-x6f26ahr 1092 40 intensity intensity NN cord-028721-x6f26ahr 1092 41 in in IN cord-028721-x6f26ahr 1092 42 the the DT cord-028721-x6f26ahr 1092 43 deeper deep JJR cord-028721-x6f26ahr 1092 44 cells cell NNS cord-028721-x6f26ahr 1092 45 . . . cord-028721-x6f26ahr 1093 1 This this DT cord-028721-x6f26ahr 1093 2 suggests suggest VBZ cord-028721-x6f26ahr 1093 3 that that IN cord-028721-x6f26ahr 1093 4 these these DT cord-028721-x6f26ahr 1093 5 may may MD cord-028721-x6f26ahr 1093 6 be be VB cord-028721-x6f26ahr 1093 7 pre pre JJ cord-028721-x6f26ahr 1093 8 - - JJ cord-028721-x6f26ahr 1093 9 Sertoli sertoli JJ cord-028721-x6f26ahr 1093 10 cells cell NNS cord-028721-x6f26ahr 1093 11 . . . cord-028721-x6f26ahr 1094 1 The the DT cord-028721-x6f26ahr 1094 2 cord cord NN cord-028721-x6f26ahr 1094 3 - - HYPH cord-028721-x6f26ahr 1094 4 like like JJ cord-028721-x6f26ahr 1094 5 structures structure NNS cord-028721-x6f26ahr 1094 6 are be VBP cord-028721-x6f26ahr 1094 7 delimited delimit VBN cord-028721-x6f26ahr 1094 8 by by IN cord-028721-x6f26ahr 1094 9 laminin laminin NN cord-028721-x6f26ahr 1094 10 and and CC cord-028721-x6f26ahr 1094 11 type type NN cord-028721-x6f26ahr 1094 12 IV IV NNP cord-028721-x6f26ahr 1094 13 collagen collagen NN cord-028721-x6f26ahr 1094 14 . . . cord-028721-x6f26ahr 1095 1 The the DT cord-028721-x6f26ahr 1095 2 second second JJ cord-028721-x6f26ahr 1095 3 larger large JJR cord-028721-x6f26ahr 1095 4 cell cell NN cord-028721-x6f26ahr 1095 5 type type NN cord-028721-x6f26ahr 1095 6 is be VBZ cord-028721-x6f26ahr 1095 7 immunoreactive immunoreactive JJ cord-028721-x6f26ahr 1095 8 for for IN cord-028721-x6f26ahr 1095 9 placenta placenta NN cord-028721-x6f26ahr 1095 10 - - HYPH cord-028721-x6f26ahr 1095 11 like like JJ cord-028721-x6f26ahr 1095 12 alkaline alkaline JJ cord-028721-x6f26ahr 1095 13 phosphatase phosphatase NN cord-028721-x6f26ahr 1095 14 ( ( -LRB- cord-028721-x6f26ahr 1095 15 PLAP PLAP NNP cord-028721-x6f26ahr 1095 16 ) ) -RRB- cord-028721-x6f26ahr 1095 17 on on IN cord-028721-x6f26ahr 1095 18 the the DT cord-028721-x6f26ahr 1095 19 surface surface NN cord-028721-x6f26ahr 1095 20 , , , cord-028721-x6f26ahr 1095 21 suggesting suggest VBG cord-028721-x6f26ahr 1095 22 that that IN cord-028721-x6f26ahr 1095 23 it -PRON- PRP cord-028721-x6f26ahr 1095 24 is be VBZ cord-028721-x6f26ahr 1095 25 related relate VBN cord-028721-x6f26ahr 1095 26 to to IN cord-028721-x6f26ahr 1095 27 the the DT cord-028721-x6f26ahr 1095 28 gonocyte gonocyte NNP cord-028721-x6f26ahr 1095 29 . . . cord-028721-x6f26ahr 1096 1 Leydig leydig NN cord-028721-x6f26ahr 1096 2 cells cell NNS cord-028721-x6f26ahr 1096 3 have have VBP cord-028721-x6f26ahr 1096 4 not not RB cord-028721-x6f26ahr 1096 5 been be VBN cord-028721-x6f26ahr 1096 6 observed observe VBN cord-028721-x6f26ahr 1096 7 among among IN cord-028721-x6f26ahr 1096 8 the the DT cord-028721-x6f26ahr 1096 9 cords cord NNS cord-028721-x6f26ahr 1096 10 of of IN cord-028721-x6f26ahr 1096 11 gonadal gonadal JJ cord-028721-x6f26ahr 1096 12 blastema blastema NNP cord-028721-x6f26ahr 1096 13 . . . cord-028721-x6f26ahr 1097 1 The the DT cord-028721-x6f26ahr 1097 2 differential differential JJ cord-028721-x6f26ahr 1097 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1097 4 of of IN cord-028721-x6f26ahr 1097 5 gonadal gonadal JJ cord-028721-x6f26ahr 1097 6 blastema blastema NNP cord-028721-x6f26ahr 1097 7 ectopia ectopia NNP cord-028721-x6f26ahr 1097 8 is be VBZ cord-028721-x6f26ahr 1097 9 with with IN cord-028721-x6f26ahr 1097 10 ovotestes ovotestis NNS cord-028721-x6f26ahr 1097 11 . . . cord-028721-x6f26ahr 1098 1 The the DT cord-028721-x6f26ahr 1098 2 small small JJ cord-028721-x6f26ahr 1098 3 size size NN cord-028721-x6f26ahr 1098 4 of of IN cord-028721-x6f26ahr 1098 5 the the DT cord-028721-x6f26ahr 1098 6 gonocytes gonocyte NNS cord-028721-x6f26ahr 1098 7 distinguishes distinguish VBZ cord-028721-x6f26ahr 1098 8 them -PRON- PRP cord-028721-x6f26ahr 1098 9 from from IN cord-028721-x6f26ahr 1098 10 ovocytes ovocyte NNS cord-028721-x6f26ahr 1098 11 , , , cord-028721-x6f26ahr 1098 12 which which WDT cord-028721-x6f26ahr 1098 13 are be VBP cord-028721-x6f26ahr 1098 14 several several JJ cord-028721-x6f26ahr 1098 15 times time NNS cord-028721-x6f26ahr 1098 16 larger large JJR cord-028721-x6f26ahr 1098 17 . . . cord-028721-x6f26ahr 1099 1 In in IN cord-028721-x6f26ahr 1099 2 addition addition NN cord-028721-x6f26ahr 1099 3 , , , cord-028721-x6f26ahr 1099 4 no no DT cord-028721-x6f26ahr 1099 5 intersex intersex NN cord-028721-x6f26ahr 1099 6 condition condition NN cord-028721-x6f26ahr 1099 7 is be VBZ cord-028721-x6f26ahr 1099 8 observed observe VBN cord-028721-x6f26ahr 1099 9 . . . cord-028721-x6f26ahr 1100 1 The the DT cord-028721-x6f26ahr 1100 2 presence presence NN cord-028721-x6f26ahr 1100 3 of of IN cord-028721-x6f26ahr 1100 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 1100 5 tubules tubule NNS cord-028721-x6f26ahr 1100 6 within within IN cord-028721-x6f26ahr 1100 7 the the DT cord-028721-x6f26ahr 1100 8 tunica tunica NNP cord-028721-x6f26ahr 1100 9 albuginea albuginea NNP cord-028721-x6f26ahr 1100 10 is be VBZ cord-028721-x6f26ahr 1100 11 rare rare JJ cord-028721-x6f26ahr 1100 12 and and CC cord-028721-x6f26ahr 1100 13 usually usually RB cord-028721-x6f26ahr 1100 14 an an DT cord-028721-x6f26ahr 1100 15 incidental incidental JJ cord-028721-x6f26ahr 1100 16 histologic histologic JJ cord-028721-x6f26ahr 1100 17 fi fi NN cord-028721-x6f26ahr 1100 18 nding nding NN cord-028721-x6f26ahr 1100 19 . . . cord-028721-x6f26ahr 1101 1 473 473 CD cord-028721-x6f26ahr 1101 2 Ectopic ectopic JJ cord-028721-x6f26ahr 1101 3 tubules tubule NNS cord-028721-x6f26ahr 1101 4 are be VBP cord-028721-x6f26ahr 1101 5 present present JJ cord-028721-x6f26ahr 1101 6 in in IN cord-028721-x6f26ahr 1101 7 approximately approximately RB cord-028721-x6f26ahr 1101 8 0.8 0.8 CD cord-028721-x6f26ahr 1101 9 % % NN cord-028721-x6f26ahr 1101 10 of of IN cord-028721-x6f26ahr 1101 11 pediatric pediatric JJ cord-028721-x6f26ahr 1101 12 autopsies autopsy NNS cord-028721-x6f26ahr 1101 13 and and CC cord-028721-x6f26ahr 1101 14 0.3 0.3 CD cord-028721-x6f26ahr 1101 15 % % NN cord-028721-x6f26ahr 1101 16 of of IN cord-028721-x6f26ahr 1101 17 adult adult NN cord-028721-x6f26ahr 1101 18 autopsies autopsy NNS cord-028721-x6f26ahr 1101 19 . . . cord-028721-x6f26ahr 1102 1 The the DT cord-028721-x6f26ahr 1102 2 lower low JJR cord-028721-x6f26ahr 1102 3 inci- inci- NN cord-028721-x6f26ahr 1102 4 dence dence NN cord-028721-x6f26ahr 1102 5 in in IN cord-028721-x6f26ahr 1102 6 adults adult NNS cord-028721-x6f26ahr 1102 7 may may MD cord-028721-x6f26ahr 1102 8 be be VB cord-028721-x6f26ahr 1102 9 explained explain VBN cord-028721-x6f26ahr 1102 10 by by IN cord-028721-x6f26ahr 1102 11 proportionally proportionally RB cord-028721-x6f26ahr 1102 12 less less JJR cord-028721-x6f26ahr 1102 13 sampling sampling NN cord-028721-x6f26ahr 1102 14 . . . cord-028721-x6f26ahr 1103 1 The the DT cord-028721-x6f26ahr 1103 2 lesion lesion NN cord-028721-x6f26ahr 1103 3 ranges range VBZ cord-028721-x6f26ahr 1103 4 from from IN cord-028721-x6f26ahr 1103 5 microscopic microscopic JJ cord-028721-x6f26ahr 1103 6 size size NN cord-028721-x6f26ahr 1103 7 to to IN cord-028721-x6f26ahr 1103 8 a a DT cord-028721-x6f26ahr 1103 9 few few JJ cord-028721-x6f26ahr 1103 10 millimeters millimeter NNS cord-028721-x6f26ahr 1103 11 in in IN cord-028721-x6f26ahr 1103 12 diameter diameter NN cord-028721-x6f26ahr 1103 13 , , , cord-028721-x6f26ahr 1103 14 and and CC cord-028721-x6f26ahr 1103 15 may may MD cord-028721-x6f26ahr 1103 16 be be VB cord-028721-x6f26ahr 1103 17 visible visible JJ cord-028721-x6f26ahr 1103 18 as as IN cord-028721-x6f26ahr 1103 19 minute minute NN cord-028721-x6f26ahr 1103 20 bulges bulge NNS cord-028721-x6f26ahr 1103 21 in in IN cord-028721-x6f26ahr 1103 22 which which WDT cord-028721-x6f26ahr 1103 23 multiple multiple JJ cord-028721-x6f26ahr 1103 24 small small JJ cord-028721-x6f26ahr 1103 25 vesicles vesicle NNS cord-028721-x6f26ahr 1103 26 protrude protrude VBP cord-028721-x6f26ahr 1103 27 through through IN cord-028721-x6f26ahr 1103 28 a a DT cord-028721-x6f26ahr 1103 29 thin thin JJ cord-028721-x6f26ahr 1103 30 tunica tunica NNP cord-028721-x6f26ahr 1103 31 albuginea albuginea NNP cord-028721-x6f26ahr 1103 32 . . . cord-028721-x6f26ahr 1104 1 474 474 CD cord-028721-x6f26ahr 1104 2 Histologically histologically RB cord-028721-x6f26ahr 1104 3 there there EX cord-028721-x6f26ahr 1104 4 are be VBP cord-028721-x6f26ahr 1104 5 groups group NNS cord-028721-x6f26ahr 1104 6 of of IN cord-028721-x6f26ahr 1104 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 1104 8 tubules tubule NNS cord-028721-x6f26ahr 1104 9 in in IN cord-028721-x6f26ahr 1104 10 the the DT cord-028721-x6f26ahr 1104 11 tunica tunica NNP cord-028721-x6f26ahr 1104 12 albuginea albuginea NNP cord-028721-x6f26ahr 1104 13 , , , cord-028721-x6f26ahr 1104 14 sometimes sometimes RB cord-028721-x6f26ahr 1104 15 accompanied accompany VBN cord-028721-x6f26ahr 1104 16 by by IN cord-028721-x6f26ahr 1104 17 Leydig Leydig NNP cord-028721-x6f26ahr 1104 18 cells cell NNS cord-028721-x6f26ahr 1104 19 . . . cord-028721-x6f26ahr 1105 1 In in IN cord-028721-x6f26ahr 1105 2 children child NNS cord-028721-x6f26ahr 1105 3 , , , cord-028721-x6f26ahr 1105 4 the the DT cord-028721-x6f26ahr 1105 5 ectopic ectopic JJ cord-028721-x6f26ahr 1105 6 tubules tubule NNS cord-028721-x6f26ahr 1105 7 appear appear VBP cord-028721-x6f26ahr 1105 8 normal normal JJ cord-028721-x6f26ahr 1105 9 ( ( -LRB- cord-028721-x6f26ahr 1105 10 Fig Fig NNP cord-028721-x6f26ahr 1105 11 . . . cord-028721-x6f26ahr 1105 12 12 12 CD cord-028721-x6f26ahr 1105 13 - - SYM cord-028721-x6f26ahr 1105 14 45 45 CD cord-028721-x6f26ahr 1105 15 ) ) -RRB- cord-028721-x6f26ahr 1105 16 , , , cord-028721-x6f26ahr 1105 17 whereas whereas IN cord-028721-x6f26ahr 1105 18 in in IN cord-028721-x6f26ahr 1105 19 adults adult NNS cord-028721-x6f26ahr 1105 20 they -PRON- PRP cord-028721-x6f26ahr 1105 21 are be VBP cord-028721-x6f26ahr 1105 22 usually usually RB cord-028721-x6f26ahr 1105 23 slightly slightly RB cord-028721-x6f26ahr 1105 24 dilated dilated JJ cord-028721-x6f26ahr 1105 25 , , , cord-028721-x6f26ahr 1105 26 although although IN cord-028721-x6f26ahr 1105 27 some some DT cord-028721-x6f26ahr 1105 28 may may MD cord-028721-x6f26ahr 1105 29 be be VB cord-028721-x6f26ahr 1105 30 hyalinized hyalinize VBN cord-028721-x6f26ahr 1105 31 . . . cord-028721-x6f26ahr 1106 1 Serial serial JJ cord-028721-x6f26ahr 1106 2 sections section NNS cord-028721-x6f26ahr 1106 3 reveal reveal VBP cord-028721-x6f26ahr 1106 4 continuity continuity NN cord-028721-x6f26ahr 1106 5 with with IN cord-028721-x6f26ahr 1106 6 the the DT cord-028721-x6f26ahr 1106 7 intraparenchymatous intraparenchymatous JJ cord-028721-x6f26ahr 1106 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 1106 9 tubules tubule NNS cord-028721-x6f26ahr 1106 10 . . . cord-028721-x6f26ahr 1107 1 Ectopia ectopia NN cord-028721-x6f26ahr 1107 2 of of IN cord-028721-x6f26ahr 1107 3 the the DT cord-028721-x6f26ahr 1107 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 1107 5 tubule tubule NNP cord-028721-x6f26ahr 1107 6 is be VBZ cord-028721-x6f26ahr 1107 7 probably probably RB cord-028721-x6f26ahr 1107 8 congenital congenital JJ cord-028721-x6f26ahr 1107 9 , , , cord-028721-x6f26ahr 1107 10 although although IN cord-028721-x6f26ahr 1107 11 it -PRON- PRP cord-028721-x6f26ahr 1107 12 has have VBZ cord-028721-x6f26ahr 1107 13 been be VBN cord-028721-x6f26ahr 1107 14 found find VBN cord-028721-x6f26ahr 1107 15 in in IN cord-028721-x6f26ahr 1107 16 elderly elderly JJ cord-028721-x6f26ahr 1107 17 men man NNS cord-028721-x6f26ahr 1107 18 . . . cord-028721-x6f26ahr 1108 1 475 475 CD cord-028721-x6f26ahr 1109 1 It -PRON- PRP cord-028721-x6f26ahr 1109 2 does do VBZ cord-028721-x6f26ahr 1109 3 not not RB cord-028721-x6f26ahr 1109 4 appear appear VB cord-028721-x6f26ahr 1109 5 to to TO cord-028721-x6f26ahr 1109 6 be be VB cord-028721-x6f26ahr 1109 7 the the DT cord-028721-x6f26ahr 1109 8 result result NN cord-028721-x6f26ahr 1109 9 of of IN cord-028721-x6f26ahr 1109 10 trauma trauma NN cord-028721-x6f26ahr 1109 11 . . . cord-028721-x6f26ahr 1110 1 The the DT cord-028721-x6f26ahr 1110 2 malformation malformation NN cord-028721-x6f26ahr 1110 3 probably probably RB cord-028721-x6f26ahr 1110 4 arises arise VBZ cord-028721-x6f26ahr 1110 5 in in IN cord-028721-x6f26ahr 1110 6 the the DT cord-028721-x6f26ahr 1110 7 sixth sixth JJ cord-028721-x6f26ahr 1110 8 week week NN cord-028721-x6f26ahr 1110 9 of of IN cord-028721-x6f26ahr 1110 10 gestation gestation NN cord-028721-x6f26ahr 1110 11 , , , cord-028721-x6f26ahr 1110 12 when when WRB cord-028721-x6f26ahr 1110 13 the the DT cord-028721-x6f26ahr 1110 14 primordial primordial JJ cord-028721-x6f26ahr 1110 15 sex sex NN cord-028721-x6f26ahr 1110 16 cords cord NNS cord-028721-x6f26ahr 1110 17 have have VBP cord-028721-x6f26ahr 1110 18 formed form VBN cord-028721-x6f26ahr 1110 19 and and CC cord-028721-x6f26ahr 1110 20 are be VBP cord-028721-x6f26ahr 1110 21 branching branch VBG cord-028721-x6f26ahr 1110 22 toward toward IN cord-028721-x6f26ahr 1110 23 the the DT cord-028721-x6f26ahr 1110 24 gonadal gonadal JJ cord-028721-x6f26ahr 1110 25 surface surface NN cord-028721-x6f26ahr 1110 26 , , , cord-028721-x6f26ahr 1110 27 and and CC cord-028721-x6f26ahr 1110 28 the the DT cord-028721-x6f26ahr 1110 29 developing develop VBG cord-028721-x6f26ahr 1110 30 testes testis NNS cord-028721-x6f26ahr 1110 31 is be VBZ cord-028721-x6f26ahr 1110 32 covered cover VBN cord-028721-x6f26ahr 1110 33 by by IN cord-028721-x6f26ahr 1110 34 only only RB cord-028721-x6f26ahr 1110 35 one one CD cord-028721-x6f26ahr 1110 36 to to IN cord-028721-x6f26ahr 1110 37 three three CD cord-028721-x6f26ahr 1110 38 layers layer NNS cord-028721-x6f26ahr 1110 39 of of IN cord-028721-x6f26ahr 1110 40 celomic celomic JJ cord-028721-x6f26ahr 1110 41 epithelium epithelium NN cord-028721-x6f26ahr 1110 42 . . . cord-028721-x6f26ahr 1111 1 Later later RBR cord-028721-x6f26ahr 1111 2 , , , cord-028721-x6f26ahr 1111 3 the the DT cord-028721-x6f26ahr 1111 4 tunica tunica NNP cord-028721-x6f26ahr 1111 5 albuginea albuginea NNP cord-028721-x6f26ahr 1111 6 forms form VBZ cord-028721-x6f26ahr 1111 7 around around IN cord-028721-x6f26ahr 1111 8 the the DT cord-028721-x6f26ahr 1111 9 sex sex NN cord-028721-x6f26ahr 1111 10 cords cord NNS cord-028721-x6f26ahr 1111 11 and and CC cord-028721-x6f26ahr 1111 12 under under IN cord-028721-x6f26ahr 1111 13 the the DT cord-028721-x6f26ahr 1111 14 celomic celomic JJ cord-028721-x6f26ahr 1111 15 epithelium epithelium NN cord-028721-x6f26ahr 1111 16 . . . cord-028721-x6f26ahr 1112 1 Failure failure NN cord-028721-x6f26ahr 1112 2 of of IN cord-028721-x6f26ahr 1112 3 insertion insertion NN cord-028721-x6f26ahr 1112 4 of of IN cord-028721-x6f26ahr 1112 5 the the DT cord-028721-x6f26ahr 1112 6 tunica tunica NNP cord-028721-x6f26ahr 1112 7 albuginea albuginea NNP cord-028721-x6f26ahr 1112 8 between between IN cord-028721-x6f26ahr 1112 9 the the DT cord-028721-x6f26ahr 1112 10 sex sex NN cord-028721-x6f26ahr 1112 11 cords cord NNS cord-028721-x6f26ahr 1112 12 and and CC cord-028721-x6f26ahr 1112 13 celomic celomic JJ cord-028721-x6f26ahr 1112 14 epithelium epithelium NN cord-028721-x6f26ahr 1112 15 may may MD cord-028721-x6f26ahr 1112 16 entrap entrap VB cord-028721-x6f26ahr 1112 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 1112 18 tubules tubule NNS cord-028721-x6f26ahr 1112 19 . . . cord-028721-x6f26ahr 1113 1 Ectopia Ectopia NNP cord-028721-x6f26ahr 1113 2 differs differ VBZ cord-028721-x6f26ahr 1113 3 from from IN cord-028721-x6f26ahr 1113 4 testicular testicular JJ cord-028721-x6f26ahr 1113 5 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1113 6 , , , cord-028721-x6f26ahr 1113 7 a a DT cord-028721-x6f26ahr 1113 8 distinctive distinctive JJ cord-028721-x6f26ahr 1113 9 form form NN cord-028721-x6f26ahr 1113 10 of of IN cord-028721-x6f26ahr 1113 11 male male JJ cord-028721-x6f26ahr 1113 12 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1113 13 with with IN cord-028721-x6f26ahr 1113 14 müllerian müllerian JJ cord-028721-x6f26ahr 1113 15 remnants remnant NNS cord-028721-x6f26ahr 1113 16 . . . cord-028721-x6f26ahr 1114 1 Numerous numerous JJ cord-028721-x6f26ahr 1114 2 features feature NNS cord-028721-x6f26ahr 1114 3 , , , cord-028721-x6f26ahr 1114 4 characteristic characteristic JJ cord-028721-x6f26ahr 1114 5 of of IN cord-028721-x6f26ahr 1114 6 ectopic ectopic JJ cord-028721-x6f26ahr 1114 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 1114 8 tubules tubule NNS cord-028721-x6f26ahr 1114 9 , , , cord-028721-x6f26ahr 1114 10 distinguish distinguish VB cord-028721-x6f26ahr 1114 11 it -PRON- PRP cord-028721-x6f26ahr 1114 12 from from IN cord-028721-x6f26ahr 1114 13 other other JJ cord-028721-x6f26ahr 1114 14 conditions condition NNS cord-028721-x6f26ahr 1114 15 , , , cord-028721-x6f26ahr 1114 16 including include VBG cord-028721-x6f26ahr 1114 17 normal normal JJ cord-028721-x6f26ahr 1114 18 thickness thickness NN cord-028721-x6f26ahr 1114 19 and and CC cord-028721-x6f26ahr 1114 20 collagenization collagenization NN cord-028721-x6f26ahr 1114 21 of of IN cord-028721-x6f26ahr 1114 22 the the DT cord-028721-x6f26ahr 1114 23 tunica tunica NNP cord-028721-x6f26ahr 1114 24 albuginea albuginea NNP cord-028721-x6f26ahr 1114 25 , , , cord-028721-x6f26ahr 1114 26 absence absence NN cord-028721-x6f26ahr 1114 27 of of IN cord-028721-x6f26ahr 1114 28 interstitial interstitial JJ cord-028721-x6f26ahr 1114 29 tissue tissue NN cord-028721-x6f26ahr 1114 30 resembling resemble VBG cord-028721-x6f26ahr 1114 31 ovarian ovarian JJ cord-028721-x6f26ahr 1114 32 stroma stroma NN cord-028721-x6f26ahr 1114 33 ( ( -LRB- cord-028721-x6f26ahr 1114 34 characteristic characteristic NN cord-028721-x6f26ahr 1114 35 of of IN cord-028721-x6f26ahr 1114 36 testicular testicular JJ cord-028721-x6f26ahr 1114 37 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 1114 38 ) ) -RRB- cord-028721-x6f26ahr 1114 39 , , , cord-028721-x6f26ahr 1114 40 and and CC cord-028721-x6f26ahr 1114 41 clear clear JJ cord-028721-x6f26ahr 1114 42 delimitation delimitation NN cord-028721-x6f26ahr 1114 43 of of IN cord-028721-x6f26ahr 1114 44 the the DT cord-028721-x6f26ahr 1114 45 tunica tunica NNP cord-028721-x6f26ahr 1114 46 albuginea albuginea NNP cord-028721-x6f26ahr 1114 47 and and CC cord-028721-x6f26ahr 1114 48 testicular testicular JJ cord-028721-x6f26ahr 1114 49 parenchyma parenchyma NNS cord-028721-x6f26ahr 1114 50 ( ( -LRB- cord-028721-x6f26ahr 1114 51 see see VB cord-028721-x6f26ahr 1114 52 discussion discussion NN cord-028721-x6f26ahr 1114 53 on on IN cord-028721-x6f26ahr 1114 54 male male JJ cord-028721-x6f26ahr 1114 55 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1114 56 with with IN cord-028721-x6f26ahr 1114 57 müllerian müllerian JJ cord-028721-x6f26ahr 1114 58 remnants remnant NNS cord-028721-x6f26ahr 1114 59 , , , cord-028721-x6f26ahr 1114 60 below below RB cord-028721-x6f26ahr 1114 61 ) ) -RRB- cord-028721-x6f26ahr 1114 62 . . . cord-028721-x6f26ahr 1115 1 In in IN cord-028721-x6f26ahr 1115 2 a a DT cord-028721-x6f26ahr 1115 3 unique unique JJ cord-028721-x6f26ahr 1115 4 case case NN cord-028721-x6f26ahr 1115 5 , , , cord-028721-x6f26ahr 1115 6 there there EX cord-028721-x6f26ahr 1115 7 were be VBD cord-028721-x6f26ahr 1115 8 multiple multiple JJ cord-028721-x6f26ahr 1115 9 clusters cluster NNS cord-028721-x6f26ahr 1115 10 of of IN cord-028721-x6f26ahr 1115 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 1115 12 tubules tubule NNS cord-028721-x6f26ahr 1115 13 in in IN cord-028721-x6f26ahr 1115 14 the the DT cord-028721-x6f26ahr 1115 15 wall wall NN cord-028721-x6f26ahr 1115 16 of of IN cord-028721-x6f26ahr 1115 17 a a DT cord-028721-x6f26ahr 1115 18 hernia hernia NN cord-028721-x6f26ahr 1115 19 sac sac NN cord-028721-x6f26ahr 1115 20 that that WDT cord-028721-x6f26ahr 1115 21 accompanied accompany VBD cord-028721-x6f26ahr 1115 22 an an DT cord-028721-x6f26ahr 1115 23 undescended undescended JJ cord-028721-x6f26ahr 1115 24 testis testis NN cord-028721-x6f26ahr 1115 25 removed remove VBN cord-028721-x6f26ahr 1115 26 from from IN cord-028721-x6f26ahr 1115 27 an an DT cord-028721-x6f26ahr 1115 28 adult adult NN cord-028721-x6f26ahr 1115 29 man man NN cord-028721-x6f26ahr 1115 30 . . . cord-028721-x6f26ahr 1116 1 The the DT cord-028721-x6f26ahr 1116 2 ectopic ectopic JJ cord-028721-x6f26ahr 1116 3 tubules tubule NNS cord-028721-x6f26ahr 1116 4 were be VBD cord-028721-x6f26ahr 1116 5 not not RB cord-028721-x6f26ahr 1116 6 surrounded surround VBN cord-028721-x6f26ahr 1116 7 by by IN cord-028721-x6f26ahr 1116 8 tunica tunica NNP cord-028721-x6f26ahr 1116 9 albuginea albuginea NNP cord-028721-x6f26ahr 1116 10 and and CC cord-028721-x6f26ahr 1116 11 were be VBD cord-028721-x6f26ahr 1116 12 similar similar JJ cord-028721-x6f26ahr 1116 13 to to IN cord-028721-x6f26ahr 1116 14 those those DT cord-028721-x6f26ahr 1116 15 in in IN cord-028721-x6f26ahr 1116 16 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1116 17 testicular testicular JJ cord-028721-x6f26ahr 1116 18 parenchyma parenchyma NNS cord-028721-x6f26ahr 1116 19 with with IN cord-028721-x6f26ahr 1116 20 only only JJ cord-028721-x6f26ahr 1116 21 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1116 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 1116 23 cells cell NNS cord-028721-x6f26ahr 1116 24 . . . cord-028721-x6f26ahr 1117 1 Leydig leydig NN cord-028721-x6f26ahr 1117 2 cells cell NNS cord-028721-x6f26ahr 1117 3 occur occur VBP cord-028721-x6f26ahr 1117 4 normally normally RB cord-028721-x6f26ahr 1117 5 in in IN cord-028721-x6f26ahr 1117 6 the the DT cord-028721-x6f26ahr 1117 7 testicular testicular NNP cord-028721-x6f26ahr 1117 8 interstitium interstitium NN cord-028721-x6f26ahr 1117 9 ( ( -LRB- cord-028721-x6f26ahr 1117 10 interstitial interstitial JJ cord-028721-x6f26ahr 1117 11 Leydig Leydig NNP cord-028721-x6f26ahr 1117 12 cells cell NNS cord-028721-x6f26ahr 1117 13 ) ) -RRB- cord-028721-x6f26ahr 1117 14 and and CC cord-028721-x6f26ahr 1117 15 in in IN cord-028721-x6f26ahr 1117 16 the the DT cord-028721-x6f26ahr 1117 17 wall wall NN cord-028721-x6f26ahr 1117 18 of of IN cord-028721-x6f26ahr 1117 19 the the DT cord-028721-x6f26ahr 1117 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 1117 21 tubules tubule NNS cord-028721-x6f26ahr 1117 22 ( ( -LRB- cord-028721-x6f26ahr 1117 23 peritubular peritubular NNP cord-028721-x6f26ahr 1117 24 Leydig Leydig NNP cord-028721-x6f26ahr 1117 25 cells cell NNS cord-028721-x6f26ahr 1117 26 ) ) -RRB- cord-028721-x6f26ahr 1117 27 . . . cord-028721-x6f26ahr 1118 1 However however RB cord-028721-x6f26ahr 1118 2 , , , cord-028721-x6f26ahr 1118 3 clusters cluster NNS cord-028721-x6f26ahr 1118 4 of of IN cord-028721-x6f26ahr 1118 5 Leydig Leydig NNP cord-028721-x6f26ahr 1118 6 cells cell NNS cord-028721-x6f26ahr 1118 7 are be VBP cord-028721-x6f26ahr 1118 8 often often RB cord-028721-x6f26ahr 1118 9 observed observe VBN cord-028721-x6f26ahr 1118 10 in in IN cord-028721-x6f26ahr 1118 11 other other JJ cord-028721-x6f26ahr 1118 12 locations location NNS cord-028721-x6f26ahr 1118 13 in in IN cord-028721-x6f26ahr 1118 14 the the DT cord-028721-x6f26ahr 1118 15 testis testis NN cord-028721-x6f26ahr 1118 16 , , , cord-028721-x6f26ahr 1118 17 or or CC cord-028721-x6f26ahr 1118 18 in in IN cord-028721-x6f26ahr 1118 19 the the DT cord-028721-x6f26ahr 1118 20 epididymis epididymis NN cord-028721-x6f26ahr 1118 21 or or CC cord-028721-x6f26ahr 1118 22 spermatic spermatic JJ cord-028721-x6f26ahr 1118 23 cord cord NN cord-028721-x6f26ahr 1118 24 . . . cord-028721-x6f26ahr 1119 1 476 476 CD cord-028721-x6f26ahr 1119 2 Ectopic Ectopic NNP cord-028721-x6f26ahr 1119 3 Leydig Leydig NNP cord-028721-x6f26ahr 1119 4 cells cell NNS cord-028721-x6f26ahr 1119 5 may may MD cord-028721-x6f26ahr 1119 6 be be VB cord-028721-x6f26ahr 1119 7 found find VBN cord-028721-x6f26ahr 1119 8 in in IN cord-028721-x6f26ahr 1119 9 the the DT cord-028721-x6f26ahr 1119 10 interlobular interlobular NNP cord-028721-x6f26ahr 1119 11 septa septa NNP cord-028721-x6f26ahr 1119 12 , , , cord-028721-x6f26ahr 1119 13 477 477 CD cord-028721-x6f26ahr 1119 14 - - SYM cord-028721-x6f26ahr 1119 15 479 479 CD cord-028721-x6f26ahr 1119 16 rete rete NN cord-028721-x6f26ahr 1119 17 testis testis NN cord-028721-x6f26ahr 1119 18 , , , cord-028721-x6f26ahr 1119 19 tunica tunica NNP cord-028721-x6f26ahr 1119 20 albuginea albuginea NNP cord-028721-x6f26ahr 1119 21 , , , cord-028721-x6f26ahr 1119 22 [ [ -LRB- cord-028721-x6f26ahr 1119 23 480 480 CD cord-028721-x6f26ahr 1119 24 ] ] -RRB- cord-028721-x6f26ahr 1119 25 [ [ -LRB- cord-028721-x6f26ahr 1119 26 481 481 CD cord-028721-x6f26ahr 1119 27 ] ] -RRB- cord-028721-x6f26ahr 1119 28 [ [ -LRB- cord-028721-x6f26ahr 1119 29 482 482 CD cord-028721-x6f26ahr 1119 30 ] ] -RRB- cord-028721-x6f26ahr 1119 31 or or CC cord-028721-x6f26ahr 1119 32 within within IN cord-028721-x6f26ahr 1119 33 hyalinized hyalinize VBN cord-028721-x6f26ahr 1119 34 seminiferous seminiferous JJ cord-028721-x6f26ahr 1119 35 tubules tubule NNS cord-028721-x6f26ahr 1119 36 . . . cord-028721-x6f26ahr 1120 1 478 478 CD cord-028721-x6f26ahr 1120 2 , , , cord-028721-x6f26ahr 1120 3 [ [ -LRB- cord-028721-x6f26ahr 1120 4 483 483 CD cord-028721-x6f26ahr 1120 5 ] ] -RRB- cord-028721-x6f26ahr 1120 6 [ [ -LRB- cord-028721-x6f26ahr 1120 7 484 484 CD cord-028721-x6f26ahr 1120 8 ] ] -RRB- cord-028721-x6f26ahr 1120 9 [ [ -LRB- cord-028721-x6f26ahr 1120 10 485 485 CD cord-028721-x6f26ahr 1120 11 ] ] -RRB- cord-028721-x6f26ahr 1120 12 Intratubular Intratubular NNP cord-028721-x6f26ahr 1120 13 Leydig Leydig NNP cord-028721-x6f26ahr 1120 14 cells cell NNS cord-028721-x6f26ahr 1120 15 are be VBP cord-028721-x6f26ahr 1120 16 found find VBN cord-028721-x6f26ahr 1120 17 only only RB cord-028721-x6f26ahr 1120 18 in in IN cord-028721-x6f26ahr 1120 19 tubules tubule NNS cord-028721-x6f26ahr 1120 20 with with IN cord-028721-x6f26ahr 1120 21 advanced advanced JJ cord-028721-x6f26ahr 1120 22 atrophy atrophy NN cord-028721-x6f26ahr 1120 23 and and CC cord-028721-x6f26ahr 1120 24 marked mark VBN cord-028721-x6f26ahr 1120 25 thickening thickening NN cord-028721-x6f26ahr 1120 26 of of IN cord-028721-x6f26ahr 1120 27 the the DT cord-028721-x6f26ahr 1120 28 tunica tunica NNP cord-028721-x6f26ahr 1120 29 propria propria NNP cord-028721-x6f26ahr 1120 30 , , , cord-028721-x6f26ahr 1120 31 including include VBG cord-028721-x6f26ahr 1120 32 the the DT cord-028721-x6f26ahr 1120 33 tubules tubule NNS cord-028721-x6f26ahr 1120 34 in in IN cord-028721-x6f26ahr 1120 35 adult adult NN cord-028721-x6f26ahr 1120 36 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1120 37 testes testis NNS cord-028721-x6f26ahr 1120 38 , , , cord-028721-x6f26ahr 1120 39 those those DT cord-028721-x6f26ahr 1120 40 of of IN cord-028721-x6f26ahr 1120 41 men man NNS cord-028721-x6f26ahr 1120 42 with with IN cord-028721-x6f26ahr 1120 43 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 1120 44 's 's POS cord-028721-x6f26ahr 1120 45 syndrome syndrome NN cord-028721-x6f26ahr 1120 46 , , , cord-028721-x6f26ahr 1120 47 and and CC cord-028721-x6f26ahr 1120 48 in in IN cord-028721-x6f26ahr 1120 49 some some DT cord-028721-x6f26ahr 1120 50 other other JJ cord-028721-x6f26ahr 1120 51 primary primary JJ cord-028721-x6f26ahr 1120 52 hypogonadisms hypogonadism NNS cord-028721-x6f26ahr 1120 53 ( ( -LRB- cord-028721-x6f26ahr 1120 54 Fig Fig NNP cord-028721-x6f26ahr 1120 55 . . . cord-028721-x6f26ahr 1120 56 12 12 CD cord-028721-x6f26ahr 1120 57 - - SYM cord-028721-x6f26ahr 1120 58 46 46 CD cord-028721-x6f26ahr 1120 59 ) ) -RRB- cord-028721-x6f26ahr 1120 60 . . . cord-028721-x6f26ahr 1121 1 Immunohistochemical Immunohistochemical NNP cord-028721-x6f26ahr 1121 2 studies study NNS cord-028721-x6f26ahr 1121 3 suggest suggest VBP cord-028721-x6f26ahr 1121 4 that that IN cord-028721-x6f26ahr 1121 5 the the DT cord-028721-x6f26ahr 1121 6 endocrine endocrine JJ cord-028721-x6f26ahr 1121 7 function function NN cord-028721-x6f26ahr 1121 8 of of IN cord-028721-x6f26ahr 1121 9 these these DT cord-028721-x6f26ahr 1121 10 Leydig Leydig NNP cord-028721-x6f26ahr 1121 11 cells cell NNS cord-028721-x6f26ahr 1121 12 is be VBZ cord-028721-x6f26ahr 1121 13 low low JJ cord-028721-x6f26ahr 1121 14 . . . cord-028721-x6f26ahr 1122 1 486 486 CD cord-028721-x6f26ahr 1123 1 Several several JJ cord-028721-x6f26ahr 1123 2 theories theory NNS cord-028721-x6f26ahr 1123 3 have have VBP cord-028721-x6f26ahr 1123 4 been be VBN cord-028721-x6f26ahr 1123 5 offered offer VBN cord-028721-x6f26ahr 1123 6 to to TO cord-028721-x6f26ahr 1123 7 account account VB cord-028721-x6f26ahr 1123 8 for for IN cord-028721-x6f26ahr 1123 9 these these DT cord-028721-x6f26ahr 1123 10 ectopic ectopic JJ cord-028721-x6f26ahr 1123 11 cells cell NNS cord-028721-x6f26ahr 1123 12 , , , cord-028721-x6f26ahr 1123 13 including include VBG cord-028721-x6f26ahr 1123 14 in in IN cord-028721-x6f26ahr 1123 15 situ situ JJ cord-028721-x6f26ahr 1123 16 differentiation differentiation NN cord-028721-x6f26ahr 1123 17 , , , cord-028721-x6f26ahr 1123 18 migration migration NN cord-028721-x6f26ahr 1123 19 from from IN cord-028721-x6f26ahr 1123 20 the the DT cord-028721-x6f26ahr 1123 21 testicular testicular NNP cord-028721-x6f26ahr 1123 22 interstitium interstitium NN cord-028721-x6f26ahr 1123 23 , , , cord-028721-x6f26ahr 1123 24 and and CC cord-028721-x6f26ahr 1123 25 trapping trapping NN cord-028721-x6f26ahr 1123 26 of of IN cord-028721-x6f26ahr 1123 27 peritubular peritubular JJ cord-028721-x6f26ahr 1123 28 Leydig Leydig NNP cord-028721-x6f26ahr 1123 29 cells cell NNS cord-028721-x6f26ahr 1123 30 in in IN cord-028721-x6f26ahr 1123 31 the the DT cord-028721-x6f26ahr 1123 32 tunica tunica NNP cord-028721-x6f26ahr 1123 33 propria propria FW cord-028721-x6f26ahr 1123 34 during during IN cord-028721-x6f26ahr 1123 35 its -PRON- PRP$ cord-028721-x6f26ahr 1123 36 thickening thickening NN cord-028721-x6f26ahr 1123 37 . . . cord-028721-x6f26ahr 1124 1 487 487 CD cord-028721-x6f26ahr 1124 2 Leydig Leydig NNP cord-028721-x6f26ahr 1124 3 cells cell NNS cord-028721-x6f26ahr 1124 4 are be VBP cord-028721-x6f26ahr 1124 5 commonly commonly RB cord-028721-x6f26ahr 1124 6 found find VBN cord-028721-x6f26ahr 1124 7 in in IN cord-028721-x6f26ahr 1124 8 the the DT cord-028721-x6f26ahr 1124 9 epididymis epididymis NN cord-028721-x6f26ahr 1124 10 487 487 CD cord-028721-x6f26ahr 1124 11 and and CC cord-028721-x6f26ahr 1124 12 spermatic spermatic JJ cord-028721-x6f26ahr 1124 13 cord cord NN cord-028721-x6f26ahr 1124 14 ; ; : cord-028721-x6f26ahr 1124 15 488,489 488,489 CD cord-028721-x6f26ahr 1124 16 26 26 CD cord-028721-x6f26ahr 1124 17 of of IN cord-028721-x6f26ahr 1124 18 64 64 CD cord-028721-x6f26ahr 1124 19 autopsies autopsy NNS cord-028721-x6f26ahr 1124 20 had have VBD cord-028721-x6f26ahr 1124 21 such such JJ cord-028721-x6f26ahr 1124 22 foci focus NNS cord-028721-x6f26ahr 1124 23 . . . cord-028721-x6f26ahr 1125 1 490 490 CD cord-028721-x6f26ahr 1126 1 Extratesticular Extratesticular NNP cord-028721-x6f26ahr 1126 2 Leydig Leydig NNP cord-028721-x6f26ahr 1126 3 cells cell NNS cord-028721-x6f26ahr 1126 4 usually usually RB cord-028721-x6f26ahr 1126 5 form form VBP cord-028721-x6f26ahr 1126 6 small small JJ cord-028721-x6f26ahr 1126 7 groups group NNS cord-028721-x6f26ahr 1126 8 within within IN cord-028721-x6f26ahr 1126 9 or or CC cord-028721-x6f26ahr 1126 10 adjacent adjacent JJ cord-028721-x6f26ahr 1126 11 to to IN cord-028721-x6f26ahr 1126 12 nerves nerve NNS cord-028721-x6f26ahr 1127 1 ( ( -LRB- cord-028721-x6f26ahr 1127 2 Fig Fig NNP cord-028721-x6f26ahr 1127 3 . . . cord-028721-x6f26ahr 1127 4 12 12 CD cord-028721-x6f26ahr 1127 5 - - SYM cord-028721-x6f26ahr 1127 6 47 47 CD cord-028721-x6f26ahr 1127 7 ) ) -RRB- cord-028721-x6f26ahr 1127 8 . . . cord-028721-x6f26ahr 1128 1 477 477 CD cord-028721-x6f26ahr 1128 2 , , , cord-028721-x6f26ahr 1128 3 490 490 CD cord-028721-x6f26ahr 1129 1 The the DT cord-028721-x6f26ahr 1129 2 occurrence occurrence NN cord-028721-x6f26ahr 1129 3 of of IN cord-028721-x6f26ahr 1129 4 ectopic ectopic JJ cord-028721-x6f26ahr 1129 5 Leydig Leydig NNP cord-028721-x6f26ahr 1129 6 cells cell NNS cord-028721-x6f26ahr 1129 7 in in IN cord-028721-x6f26ahr 1129 8 the the DT cord-028721-x6f26ahr 1129 9 albuginea albuginea NN cord-028721-x6f26ahr 1129 10 , , , cord-028721-x6f26ahr 1129 11 epididymis epididymis NN cord-028721-x6f26ahr 1129 12 , , , cord-028721-x6f26ahr 1129 13 or or CC cord-028721-x6f26ahr 1129 14 spermatic spermatic JJ cord-028721-x6f26ahr 1129 15 cord cord NN cord-028721-x6f26ahr 1129 16 may may MD cord-028721-x6f26ahr 1129 17 account account VB cord-028721-x6f26ahr 1129 18 for for IN cord-028721-x6f26ahr 1129 19 the the DT cord-028721-x6f26ahr 1129 20 rare rare JJ cord-028721-x6f26ahr 1129 21 cases case NNS cord-028721-x6f26ahr 1129 22 of of IN cord-028721-x6f26ahr 1129 23 Leydig Leydig NNP cord-028721-x6f26ahr 1129 24 cell cell NN cord-028721-x6f26ahr 1129 25 tumor tumor NN cord-028721-x6f26ahr 1129 26 in in IN cord-028721-x6f26ahr 1129 27 these these DT cord-028721-x6f26ahr 1129 28 paratesticular paratesticular JJ cord-028721-x6f26ahr 1129 29 structures structure NNS cord-028721-x6f26ahr 1129 30 . . . cord-028721-x6f26ahr 1130 1 Ectopic Ectopic NNP cord-028721-x6f26ahr 1130 2 Leydig Leydig NNP cord-028721-x6f26ahr 1130 3 cells cell NNS cord-028721-x6f26ahr 1130 4 should should MD cord-028721-x6f26ahr 1130 5 not not RB cord-028721-x6f26ahr 1130 6 be be VB cord-028721-x6f26ahr 1130 7 misinterpreted misinterpret VBN cord-028721-x6f26ahr 1130 8 as as IN cord-028721-x6f26ahr 1130 9 tumor tumor NN cord-028721-x6f26ahr 1130 10 cells cell NNS cord-028721-x6f26ahr 1130 11 ( ( -LRB- cord-028721-x6f26ahr 1130 12 infi infi NNP cord-028721-x6f26ahr 1130 13 ltration ltration NNP cord-028721-x6f26ahr 1130 14 or or CC cord-028721-x6f26ahr 1130 15 metastasis metastasis NN cord-028721-x6f26ahr 1130 16 ) ) -RRB- cord-028721-x6f26ahr 1130 17 when when WRB cord-028721-x6f26ahr 1130 18 malignancy malignancy NN cord-028721-x6f26ahr 1130 19 of of IN cord-028721-x6f26ahr 1130 20 a a DT cord-028721-x6f26ahr 1130 21 testicular testicular JJ cord-028721-x6f26ahr 1130 22 Leydig Leydig NNP cord-028721-x6f26ahr 1130 23 cell cell NN cord-028721-x6f26ahr 1130 24 tumor tumor NN cord-028721-x6f26ahr 1130 25 is be VBZ cord-028721-x6f26ahr 1130 26 suspected suspect VBN cord-028721-x6f26ahr 1130 27 . . . cord-028721-x6f26ahr 1131 1 Other other JJ cord-028721-x6f26ahr 1131 2 rare rare JJ cord-028721-x6f26ahr 1131 3 forms form NNS cord-028721-x6f26ahr 1131 4 of of IN cord-028721-x6f26ahr 1131 5 ectopia ectopia NN cord-028721-x6f26ahr 1131 6 are be VBP cord-028721-x6f26ahr 1131 7 found find VBN cord-028721-x6f26ahr 1131 8 within within IN cord-028721-x6f26ahr 1131 9 and and CC cord-028721-x6f26ahr 1131 10 outside outside IN cord-028721-x6f26ahr 1131 11 the the DT cord-028721-x6f26ahr 1131 12 testis testis NN cord-028721-x6f26ahr 1131 13 . . . cord-028721-x6f26ahr 1132 1 Intratesticular Intratesticular NNP cord-028721-x6f26ahr 1132 2 ectopia ectopia NNP cord-028721-x6f26ahr 1132 3 includes include VBZ cord-028721-x6f26ahr 1132 4 adrenal adrenal JJ cord-028721-x6f26ahr 1132 5 cortical cortical JJ cord-028721-x6f26ahr 1132 6 ectopia ectopia NN cord-028721-x6f26ahr 1132 7 , , , cord-028721-x6f26ahr 1132 8 osseous osseous JJ cord-028721-x6f26ahr 1132 9 and and CC cord-028721-x6f26ahr 1132 10 adipose adipose JJ cord-028721-x6f26ahr 1132 11 tissue tissue NN cord-028721-x6f26ahr 1132 12 heterotopia heterotopia NN cord-028721-x6f26ahr 1132 13 , , , cord-028721-x6f26ahr 1132 14 and and CC cord-028721-x6f26ahr 1132 15 ectopia ectopia NN cord-028721-x6f26ahr 1132 16 of of IN cord-028721-x6f26ahr 1132 17 the the DT cord-028721-x6f26ahr 1132 18 ductus ductus NN cord-028721-x6f26ahr 1132 19 epididymidis epididymidis NN cord-028721-x6f26ahr 1132 20 . . . cord-028721-x6f26ahr 1133 1 Extratesticular Extratesticular NNP cord-028721-x6f26ahr 1133 2 ectopia ectopia NN cord-028721-x6f26ahr 1133 3 includes include VBZ cord-028721-x6f26ahr 1133 4 splenic splenic JJ cord-028721-x6f26ahr 1133 5 ectopia ectopia NN cord-028721-x6f26ahr 1133 6 ( ( -LRB- cord-028721-x6f26ahr 1133 7 splenogonadal splenogonadal JJ cord-028721-x6f26ahr 1133 8 fusion fusion NN cord-028721-x6f26ahr 1133 9 ) ) -RRB- cord-028721-x6f26ahr 1133 10 , , , cord-028721-x6f26ahr 1133 11 hepatic hepatic JJ cord-028721-x6f26ahr 1133 12 ectopia ectopia NN cord-028721-x6f26ahr 1133 13 ( ( -LRB- cord-028721-x6f26ahr 1133 14 hepatotes- hepatotes- JJ cord-028721-x6f26ahr 1133 15 Adrenal adrenal JJ cord-028721-x6f26ahr 1133 16 cortical cortical JJ cord-028721-x6f26ahr 1133 17 ectopia ectopia NN cord-028721-x6f26ahr 1133 18 may may MD cord-028721-x6f26ahr 1133 19 be be VB cord-028721-x6f26ahr 1133 20 important important JJ cord-028721-x6f26ahr 1133 21 in in IN cord-028721-x6f26ahr 1133 22 two two CD cord-028721-x6f26ahr 1133 23 conditions condition NNS cord-028721-x6f26ahr 1133 24 that that WDT cord-028721-x6f26ahr 1133 25 develop develop VBP cord-028721-x6f26ahr 1133 26 tumoral tumoral JJ cord-028721-x6f26ahr 1133 27 masses masse NNS cord-028721-x6f26ahr 1133 28 : : : cord-028721-x6f26ahr 1133 29 adrenogenital adrenogenital NNP cord-028721-x6f26ahr 1133 30 syndrome syndrome NN cord-028721-x6f26ahr 1133 31 and and CC cord-028721-x6f26ahr 1133 32 Nelson Nelson NNP cord-028721-x6f26ahr 1133 33 's 's POS cord-028721-x6f26ahr 1133 34 syndrome syndrome NN cord-028721-x6f26ahr 1133 35 . . . cord-028721-x6f26ahr 1134 1 Tumors tumor NNS cord-028721-x6f26ahr 1134 2 in in IN cord-028721-x6f26ahr 1134 3 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 1134 4 syndrome syndrome NN cord-028721-x6f26ahr 1134 5 appear appear VBP cord-028721-x6f26ahr 1134 6 in in IN cord-028721-x6f26ahr 1134 7 8.2 8.2 CD cord-028721-x6f26ahr 1134 8 % % NN cord-028721-x6f26ahr 1134 9 of of IN cord-028721-x6f26ahr 1134 10 patients patient NNS cord-028721-x6f26ahr 1134 11 with with IN cord-028721-x6f26ahr 1134 12 congenital congenital JJ cord-028721-x6f26ahr 1134 13 adrenal adrenal JJ cord-028721-x6f26ahr 1134 14 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1134 15 , , , cord-028721-x6f26ahr 1134 16 appearing appear VBG cord-028721-x6f26ahr 1134 17 as as IN cord-028721-x6f26ahr 1134 18 bilateral bilateral JJ cord-028721-x6f26ahr 1134 19 testicular testicular JJ cord-028721-x6f26ahr 1134 20 masses masse NNS cord-028721-x6f26ahr 1134 21 of of IN cord-028721-x6f26ahr 1134 22 synchronous synchronous JJ cord-028721-x6f26ahr 1134 23 growth growth NN cord-028721-x6f26ahr 1134 24 . . . cord-028721-x6f26ahr 1135 1 These these DT cord-028721-x6f26ahr 1135 2 tumors tumor NNS cord-028721-x6f26ahr 1135 3 consist consist VBP cord-028721-x6f26ahr 1135 4 of of IN cord-028721-x6f26ahr 1135 5 well well RB cord-028721-x6f26ahr 1135 6 delimited delimited JJ cord-028721-x6f26ahr 1135 7 but but CC cord-028721-x6f26ahr 1135 8 non non JJ cord-028721-x6f26ahr 1135 9 - - JJ cord-028721-x6f26ahr 1135 10 encapsulated encapsulated JJ cord-028721-x6f26ahr 1135 11 yellow yellow JJ cord-028721-x6f26ahr 1135 12 nodules nodule NNS cord-028721-x6f26ahr 1135 13 , , , cord-028721-x6f26ahr 1135 14 several several JJ cord-028721-x6f26ahr 1135 15 centimeters centimeter NNS cord-028721-x6f26ahr 1135 16 long long RB cord-028721-x6f26ahr 1135 17 , , , cord-028721-x6f26ahr 1135 18 composed compose VBN cord-028721-x6f26ahr 1135 19 of of IN cord-028721-x6f26ahr 1135 20 large large JJ cord-028721-x6f26ahr 1135 21 microvacuolated microvacuolate VBN cord-028721-x6f26ahr 1135 22 cells cell NNS cord-028721-x6f26ahr 1135 23 . . . cord-028721-x6f26ahr 1136 1 The the DT cord-028721-x6f26ahr 1136 2 cause cause NN cord-028721-x6f26ahr 1136 3 seems seem VBZ cord-028721-x6f26ahr 1136 4 to to TO cord-028721-x6f26ahr 1136 5 be be VB cord-028721-x6f26ahr 1136 6 prolonged prolong VBN cord-028721-x6f26ahr 1136 7 stimulation stimulation NN cord-028721-x6f26ahr 1136 8 by by IN cord-028721-x6f26ahr 1136 9 elevated elevate VBN cord-028721-x6f26ahr 1136 10 ACTH ACTH NNP cord-028721-x6f26ahr 1136 11 secretion secretion NN cord-028721-x6f26ahr 1136 12 . . . cord-028721-x6f26ahr 1137 1 The the DT cord-028721-x6f26ahr 1137 2 differential differential JJ cord-028721-x6f26ahr 1137 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1137 4 includes include VBZ cord-028721-x6f26ahr 1137 5 Leydig Leydig NNP cord-028721-x6f26ahr 1137 6 cell cell NN cord-028721-x6f26ahr 1137 7 tumor tumor NN cord-028721-x6f26ahr 1137 8 . . . cord-028721-x6f26ahr 1138 1 The the DT cord-028721-x6f26ahr 1138 2 diagnosis diagnosis NN cord-028721-x6f26ahr 1138 3 of of IN cord-028721-x6f26ahr 1138 4 tumors tumor NNS cord-028721-x6f26ahr 1138 5 in in IN cord-028721-x6f26ahr 1138 6 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 1138 7 syndrome syndrome NN cord-028721-x6f26ahr 1138 8 is be VBZ cord-028721-x6f26ahr 1138 9 supported support VBN cord-028721-x6f26ahr 1138 10 by by IN cord-028721-x6f26ahr 1138 11 a a DT cord-028721-x6f26ahr 1138 12 family family NN cord-028721-x6f26ahr 1138 13 or or CC cord-028721-x6f26ahr 1138 14 personal personal JJ cord-028721-x6f26ahr 1138 15 history history NN cord-028721-x6f26ahr 1138 16 of of IN cord-028721-x6f26ahr 1138 17 salt salt NN cord-028721-x6f26ahr 1138 18 - - HYPH cord-028721-x6f26ahr 1138 19 lost lose VBN cord-028721-x6f26ahr 1138 20 syndrome syndrome NN cord-028721-x6f26ahr 1138 21 or or CC cord-028721-x6f26ahr 1138 22 hypertension hypertension NN cord-028721-x6f26ahr 1138 23 , , , cord-028721-x6f26ahr 1138 24 demonstration demonstration NN cord-028721-x6f26ahr 1138 25 of of IN cord-028721-x6f26ahr 1138 26 11 11 CD cord-028721-x6f26ahr 1138 27 β β NNP cord-028721-x6f26ahr 1138 28 - - HYPH cord-028721-x6f26ahr 1138 29 hydroxysteroids hydroxysteroids NNP cord-028721-x6f26ahr 1138 30 ( ( -LRB- cord-028721-x6f26ahr 1138 31 a a DT cord-028721-x6f26ahr 1138 32 specifi specifi NN cord-028721-x6f26ahr 1138 33 c c NN cord-028721-x6f26ahr 1138 34 marker marker NN cord-028721-x6f26ahr 1138 35 for for IN cord-028721-x6f26ahr 1138 36 adrenal adrenal JJ cord-028721-x6f26ahr 1138 37 cortex cortex NNS cord-028721-x6f26ahr 1138 38 ) ) -RRB- cord-028721-x6f26ahr 1138 39 in in IN cord-028721-x6f26ahr 1138 40 spermatic spermatic JJ cord-028721-x6f26ahr 1138 41 vein vein NN cord-028721-x6f26ahr 1138 42 blood blood NN cord-028721-x6f26ahr 1138 43 , , , cord-028721-x6f26ahr 1138 44 or or CC cord-028721-x6f26ahr 1138 45 a a DT cord-028721-x6f26ahr 1138 46 rapid rapid JJ cord-028721-x6f26ahr 1138 47 positive positive JJ cord-028721-x6f26ahr 1138 48 response response NN cord-028721-x6f26ahr 1138 49 of of IN cord-028721-x6f26ahr 1138 50 tumor tumor NN cord-028721-x6f26ahr 1138 51 to to IN cord-028721-x6f26ahr 1138 52 corticoid corticoid NN cord-028721-x6f26ahr 1138 53 treatment treatment NN cord-028721-x6f26ahr 1138 54 . . . cord-028721-x6f26ahr 1139 1 Nelson Nelson NNP cord-028721-x6f26ahr 1139 2 's 's POS cord-028721-x6f26ahr 1139 3 syndrome syndrome NN cord-028721-x6f26ahr 1139 4 occurs occur VBZ cord-028721-x6f26ahr 1139 5 in in IN cord-028721-x6f26ahr 1139 6 patients patient NNS cord-028721-x6f26ahr 1139 7 who who WP cord-028721-x6f26ahr 1139 8 , , , cord-028721-x6f26ahr 1139 9 after after IN cord-028721-x6f26ahr 1139 10 adrenalectomy adrenalectomy NN cord-028721-x6f26ahr 1139 11 for for IN cord-028721-x6f26ahr 1139 12 treatment treatment NN cord-028721-x6f26ahr 1139 13 of of IN cord-028721-x6f26ahr 1139 14 Cushing Cushing NNP cord-028721-x6f26ahr 1139 15 's 's POS cord-028721-x6f26ahr 1139 16 syndrome syndrome NN cord-028721-x6f26ahr 1139 17 , , , cord-028721-x6f26ahr 1139 18 develop develop VB cord-028721-x6f26ahr 1139 19 an an DT cord-028721-x6f26ahr 1139 20 ACTH ACTH NNP cord-028721-x6f26ahr 1139 21 - - HYPH cord-028721-x6f26ahr 1139 22 secreting secrete VBG cord-028721-x6f26ahr 1139 23 pituitary pituitary JJ cord-028721-x6f26ahr 1139 24 adenoma adenoma NN cord-028721-x6f26ahr 1139 25 . . . cord-028721-x6f26ahr 1140 1 These these DT cord-028721-x6f26ahr 1140 2 patients patient NNS cord-028721-x6f26ahr 1140 3 may may MD cord-028721-x6f26ahr 1140 4 develop develop VB cord-028721-x6f26ahr 1140 5 testicular testicular JJ cord-028721-x6f26ahr 1140 6 tumor tumor NN cord-028721-x6f26ahr 1140 7 growth growth NN cord-028721-x6f26ahr 1140 8 similar similar JJ cord-028721-x6f26ahr 1140 9 to to IN cord-028721-x6f26ahr 1140 10 that that DT cord-028721-x6f26ahr 1140 11 in in IN cord-028721-x6f26ahr 1140 12 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 1140 13 syndrome syndrome NN cord-028721-x6f26ahr 1140 14 . . . cord-028721-x6f26ahr 1141 1 Most Most JJS cord-028721-x6f26ahr 1141 2 Nelson Nelson NNP cord-028721-x6f26ahr 1141 3 's 's POS cord-028721-x6f26ahr 1141 4 syndrome syndrome NN cord-028721-x6f26ahr 1141 5 tumors tumor NNS cord-028721-x6f26ahr 1141 6 do do VBP cord-028721-x6f26ahr 1141 7 not not RB cord-028721-x6f26ahr 1141 8 respond respond VB cord-028721-x6f26ahr 1141 9 to to IN cord-028721-x6f26ahr 1141 10 dexametasone dexametasone CD cord-028721-x6f26ahr 1141 11 treatment treatment NN cord-028721-x6f26ahr 1141 12 . . . cord-028721-x6f26ahr 1142 1 Cartilaginous Cartilaginous NNP cord-028721-x6f26ahr 1142 2 heterotopia heterotopia NNP cord-028721-x6f26ahr 1142 3 may may MD cord-028721-x6f26ahr 1142 4 be be VB cord-028721-x6f26ahr 1142 5 found find VBN cord-028721-x6f26ahr 1142 6 in in IN cord-028721-x6f26ahr 1142 7 the the DT cord-028721-x6f26ahr 1142 8 caput caput NN cord-028721-x6f26ahr 1142 9 of of IN cord-028721-x6f26ahr 1142 10 the the DT cord-028721-x6f26ahr 1142 11 epididymis epididymis NN cord-028721-x6f26ahr 1142 12 and and CC cord-028721-x6f26ahr 1142 13 has have VBZ cord-028721-x6f26ahr 1142 14 been be VBN cord-028721-x6f26ahr 1142 15 attributed attribute VBN cord-028721-x6f26ahr 1142 16 to to IN cord-028721-x6f26ahr 1142 17 metaplasia metaplasia NN cord-028721-x6f26ahr 1142 18 of of IN cord-028721-x6f26ahr 1142 19 metanephric metanephric JJ cord-028721-x6f26ahr 1142 20 rests rest NNS cord-028721-x6f26ahr 1142 21 . . . cord-028721-x6f26ahr 1143 1 Osseous Osseous NNP cord-028721-x6f26ahr 1143 2 heterotopia heterotopia NN cord-028721-x6f26ahr 1143 3 ( ( -LRB- cord-028721-x6f26ahr 1143 4 testicular testicular JJ cord-028721-x6f26ahr 1143 5 osteoma osteoma NNP cord-028721-x6f26ahr 1143 6 ) ) -RRB- cord-028721-x6f26ahr 1143 7 is be VBZ cord-028721-x6f26ahr 1143 8 a a DT cord-028721-x6f26ahr 1143 9 metaplasia metaplasia NN cord-028721-x6f26ahr 1143 10 occurring occur VBG cord-028721-x6f26ahr 1143 11 in in IN cord-028721-x6f26ahr 1143 12 areas area NNS cord-028721-x6f26ahr 1143 13 of of IN cord-028721-x6f26ahr 1143 14 the the DT cord-028721-x6f26ahr 1143 15 testicular testicular JJ cord-028721-x6f26ahr 1143 16 parenchyma parenchyma NNS cord-028721-x6f26ahr 1143 17 with with IN cord-028721-x6f26ahr 1143 18 fi fi NNP cord-028721-x6f26ahr 1143 19 brosis brosis NN cord-028721-x6f26ahr 1143 20 or or CC cord-028721-x6f26ahr 1143 21 ischemia ischemia NN cord-028721-x6f26ahr 1143 22 . . . cord-028721-x6f26ahr 1144 1 491 491 CD cord-028721-x6f26ahr 1145 1 Adipose adipose JJ cord-028721-x6f26ahr 1145 2 metaplasia metaplasia NN cord-028721-x6f26ahr 1145 3 is be VBZ cord-028721-x6f26ahr 1145 4 frequent frequent JJ cord-028721-x6f26ahr 1145 5 in in IN cord-028721-x6f26ahr 1145 6 undescended undescended JJ cord-028721-x6f26ahr 1145 7 testis testis NN cord-028721-x6f26ahr 1145 8 , , , cord-028721-x6f26ahr 1145 9 elderly elderly JJ cord-028721-x6f26ahr 1145 10 men man NNS cord-028721-x6f26ahr 1145 11 , , , cord-028721-x6f26ahr 1145 12 and and CC cord-028721-x6f26ahr 1145 13 those those DT cord-028721-x6f26ahr 1145 14 with with IN cord-028721-x6f26ahr 1145 15 Cowden Cowden NNP cord-028721-x6f26ahr 1145 16 's 's POS cord-028721-x6f26ahr 1145 17 syndrome syndrome NN cord-028721-x6f26ahr 1145 18 ( ( -LRB- cord-028721-x6f26ahr 1145 19 Fig Fig NNP cord-028721-x6f26ahr 1145 20 . . . cord-028721-x6f26ahr 1145 21 12 12 CD cord-028721-x6f26ahr 1145 22 - - SYM cord-028721-x6f26ahr 1145 23 48 48 CD cord-028721-x6f26ahr 1145 24 ) ) -RRB- cord-028721-x6f26ahr 1145 25 . . . cord-028721-x6f26ahr 1146 1 492 492 CD cord-028721-x6f26ahr 1146 2 Groups group NNS cord-028721-x6f26ahr 1146 3 of of IN cord-028721-x6f26ahr 1146 4 tubular tubular JJ cord-028721-x6f26ahr 1146 5 formations formation NNS cord-028721-x6f26ahr 1146 6 that that WDT cord-028721-x6f26ahr 1146 7 resembles resemble VBZ cord-028721-x6f26ahr 1146 8 the the DT cord-028721-x6f26ahr 1146 9 epididymis epididymis NN cord-028721-x6f26ahr 1146 10 have have VBP cord-028721-x6f26ahr 1146 11 been be VBN cord-028721-x6f26ahr 1146 12 reported report VBN cord-028721-x6f26ahr 1146 13 inside inside IN cord-028721-x6f26ahr 1146 14 the the DT cord-028721-x6f26ahr 1146 15 testicular testicular JJ cord-028721-x6f26ahr 1146 16 parenchyma parenchyma NN cord-028721-x6f26ahr 1146 17 in in IN cord-028721-x6f26ahr 1146 18 testes testis NNS cord-028721-x6f26ahr 1146 19 with with IN cord-028721-x6f26ahr 1146 20 marked marked JJ cord-028721-x6f26ahr 1146 21 tubular tubular JJ cord-028721-x6f26ahr 1146 22 atrophy atrophy NN cord-028721-x6f26ahr 1146 23 , , , cord-028721-x6f26ahr 1146 24 and and CC cord-028721-x6f26ahr 1146 25 probably probably RB cord-028721-x6f26ahr 1146 26 represent represent VBP cord-028721-x6f26ahr 1146 27 a a DT cord-028721-x6f26ahr 1146 28 rare rare JJ cord-028721-x6f26ahr 1146 29 form form NN cord-028721-x6f26ahr 1146 30 of of IN cord-028721-x6f26ahr 1146 31 metaplasia metaplasia NN cord-028721-x6f26ahr 1146 32 . . . cord-028721-x6f26ahr 1147 1 493 493 CD cord-028721-x6f26ahr 1147 2 Testicular testicular JJ cord-028721-x6f26ahr 1147 3 descent descent NN cord-028721-x6f26ahr 1147 4 is be VBZ cord-028721-x6f26ahr 1147 5 not not RB cord-028721-x6f26ahr 1147 6 always always RB cord-028721-x6f26ahr 1147 7 complete complete JJ cord-028721-x6f26ahr 1147 8 at at IN cord-028721-x6f26ahr 1147 9 birth birth NN cord-028721-x6f26ahr 1147 10 , , , cord-028721-x6f26ahr 1147 11 and and CC cord-028721-x6f26ahr 1147 12 about about RB cord-028721-x6f26ahr 1147 13 3.2 3.2 CD cord-028721-x6f26ahr 1147 14 % % NN cord-028721-x6f26ahr 1147 15 of of IN cord-028721-x6f26ahr 1147 16 full full JJ cord-028721-x6f26ahr 1147 17 - - HYPH cord-028721-x6f26ahr 1147 18 term term NN cord-028721-x6f26ahr 1147 19 newborns newborn NNS cord-028721-x6f26ahr 1147 20 have have VBP cord-028721-x6f26ahr 1147 21 incompletely incompletely RB cord-028721-x6f26ahr 1147 22 descended descend VBN cord-028721-x6f26ahr 1147 23 testes testis NNS cord-028721-x6f26ahr 1147 24 . . . cord-028721-x6f26ahr 1148 1 Most Most JJS cord-028721-x6f26ahr 1148 2 of of IN cord-028721-x6f26ahr 1148 3 these these DT cord-028721-x6f26ahr 1148 4 descend descend VBP cord-028721-x6f26ahr 1148 5 within within IN cord-028721-x6f26ahr 1148 6 3 3 CD cord-028721-x6f26ahr 1148 7 months month NNS cord-028721-x6f26ahr 1148 8 , , , cord-028721-x6f26ahr 1148 9 and and CC cord-028721-x6f26ahr 1148 10 only only RB cord-028721-x6f26ahr 1148 11 0.8 0.8 CD cord-028721-x6f26ahr 1148 12 % % NN cord-028721-x6f26ahr 1148 13 of of IN cord-028721-x6f26ahr 1148 14 infants infant NNS cord-028721-x6f26ahr 1148 15 have have VBP cord-028721-x6f26ahr 1148 16 incompletely incompletely RB cord-028721-x6f26ahr 1148 17 descended descend VBN cord-028721-x6f26ahr 1148 18 testes testis NNS cord-028721-x6f26ahr 1148 19 12 12 CD cord-028721-x6f26ahr 1148 20 months month NNS cord-028721-x6f26ahr 1148 21 after after IN cord-028721-x6f26ahr 1148 22 birth birth NN cord-028721-x6f26ahr 1148 23 . . . cord-028721-x6f26ahr 1149 1 Spontaneous spontaneous JJ cord-028721-x6f26ahr 1149 2 testicular testicular JJ cord-028721-x6f26ahr 1149 3 descent descent NN cord-028721-x6f26ahr 1149 4 is be VBZ cord-028721-x6f26ahr 1149 5 exceptional exceptional JJ cord-028721-x6f26ahr 1149 6 after after IN cord-028721-x6f26ahr 1149 7 the the DT cord-028721-x6f26ahr 1149 8 fi fi NNP cord-028721-x6f26ahr 1149 9 rst rst NN cord-028721-x6f26ahr 1149 10 year year NN cord-028721-x6f26ahr 1149 11 . . . cord-028721-x6f26ahr 1150 1 In in IN cord-028721-x6f26ahr 1150 2 recent recent JJ cord-028721-x6f26ahr 1150 3 decades decade NNS cord-028721-x6f26ahr 1150 4 , , , cord-028721-x6f26ahr 1150 5 a a DT cord-028721-x6f26ahr 1150 6 signifi signifi NN cord-028721-x6f26ahr 1150 7 ca can MD cord-028721-x6f26ahr 1150 8 nt not RB cord-028721-x6f26ahr 1150 9 increase increase VB cord-028721-x6f26ahr 1150 10 in in IN cord-028721-x6f26ahr 1150 11 the the DT cord-028721-x6f26ahr 1150 12 incidence incidence NN cord-028721-x6f26ahr 1150 13 of of IN cord-028721-x6f26ahr 1150 14 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1150 15 has have VBZ cord-028721-x6f26ahr 1150 16 been be VBN cord-028721-x6f26ahr 1150 17 detected detect VBN cord-028721-x6f26ahr 1150 18 . . . cord-028721-x6f26ahr 1151 1 494 494 CD cord-028721-x6f26ahr 1152 1 Only only RB cord-028721-x6f26ahr 1152 2 5 5 CD cord-028721-x6f26ahr 1152 3 % % NN cord-028721-x6f26ahr 1152 4 of of IN cord-028721-x6f26ahr 1152 5 patients patient NNS cord-028721-x6f26ahr 1152 6 with with IN cord-028721-x6f26ahr 1152 7 impalpable impalpable JJ cord-028721-x6f26ahr 1152 8 testes testis NNS cord-028721-x6f26ahr 1152 9 are be VBP cord-028721-x6f26ahr 1152 10 actually actually RB cord-028721-x6f26ahr 1152 11 devoid devoid JJ cord-028721-x6f26ahr 1152 12 of of IN cord-028721-x6f26ahr 1152 13 testes testis NNS cord-028721-x6f26ahr 1152 14 . . . cord-028721-x6f26ahr 1153 1 Other other JJ cord-028721-x6f26ahr 1153 2 causes cause NNS cord-028721-x6f26ahr 1153 3 include include VBP cord-028721-x6f26ahr 1153 4 true true JJ cord-028721-x6f26ahr 1153 5 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1153 6 , , , cord-028721-x6f26ahr 1153 7 testicular testicular JJ cord-028721-x6f26ahr 1153 8 ectopia ectopia NN cord-028721-x6f26ahr 1153 9 , , , cord-028721-x6f26ahr 1153 10 and and CC cord-028721-x6f26ahr 1153 11 retractile retractile JJ cord-028721-x6f26ahr 1153 12 testes testis NNS cord-028721-x6f26ahr 1153 13 . . . cord-028721-x6f26ahr 1154 1 True true JJ cord-028721-x6f26ahr 1154 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1154 3 includes include VBZ cord-028721-x6f26ahr 1154 4 abdominal abdominal JJ cord-028721-x6f26ahr 1154 5 , , , cord-028721-x6f26ahr 1154 6 inguinal inguinal JJ cord-028721-x6f26ahr 1154 7 , , , cord-028721-x6f26ahr 1154 8 and and CC cord-028721-x6f26ahr 1154 9 high high JJ cord-028721-x6f26ahr 1154 10 scrotal scrotal JJ cord-028721-x6f26ahr 1154 11 testes testis NNS cord-028721-x6f26ahr 1154 12 that that WDT cord-028721-x6f26ahr 1154 13 can can MD cord-028721-x6f26ahr 1154 14 not not RB cord-028721-x6f26ahr 1154 15 be be VB cord-028721-x6f26ahr 1154 16 moved move VBN cord-028721-x6f26ahr 1154 17 to to IN cord-028721-x6f26ahr 1154 18 the the DT cord-028721-x6f26ahr 1154 19 scrotum scrotum NN cord-028721-x6f26ahr 1154 20 . . . cord-028721-x6f26ahr 1155 1 Ectopic ectopic JJ cord-028721-x6f26ahr 1155 2 testes testis NNS cord-028721-x6f26ahr 1155 3 are be VBP cord-028721-x6f26ahr 1155 4 those those DT cord-028721-x6f26ahr 1155 5 located locate VBN cord-028721-x6f26ahr 1155 6 out out IN cord-028721-x6f26ahr 1155 7 of of IN cord-028721-x6f26ahr 1155 8 the the DT cord-028721-x6f26ahr 1155 9 normal normal JJ cord-028721-x6f26ahr 1155 10 path path NN cord-028721-x6f26ahr 1155 11 of of IN cord-028721-x6f26ahr 1155 12 testicular testicular JJ cord-028721-x6f26ahr 1155 13 descent descent NN cord-028721-x6f26ahr 1155 14 ; ; : cord-028721-x6f26ahr 1155 15 the the DT cord-028721-x6f26ahr 1155 16 most most RBS cord-028721-x6f26ahr 1155 17 frequent frequent JJ cord-028721-x6f26ahr 1155 18 site site NN cord-028721-x6f26ahr 1155 19 is be VBZ cord-028721-x6f26ahr 1155 20 the the DT cord-028721-x6f26ahr 1155 21 superfi superfi NNP cord-028721-x6f26ahr 1155 22 cial cial JJ cord-028721-x6f26ahr 1155 23 inguinal inguinal JJ cord-028721-x6f26ahr 1155 24 pouch pouch NN cord-028721-x6f26ahr 1155 25 . . . cord-028721-x6f26ahr 1156 1 Other other JJ cord-028721-x6f26ahr 1156 2 rare rare JJ cord-028721-x6f26ahr 1156 3 locations location NNS cord-028721-x6f26ahr 1156 4 of of IN cord-028721-x6f26ahr 1156 5 ectopia ectopia NN cord-028721-x6f26ahr 1156 6 include include VBP cord-028721-x6f26ahr 1156 7 the the DT cord-028721-x6f26ahr 1156 8 abdominal abdominal JJ cord-028721-x6f26ahr 1156 9 wall wall NN cord-028721-x6f26ahr 1156 10 , , , cord-028721-x6f26ahr 1156 11 the the DT cord-028721-x6f26ahr 1156 12 upper upper JJ cord-028721-x6f26ahr 1156 13 thigh thigh NN cord-028721-x6f26ahr 1156 14 , , , cord-028721-x6f26ahr 1156 15 the the DT cord-028721-x6f26ahr 1156 16 perineum perineum NN cord-028721-x6f26ahr 1156 17 , , , cord-028721-x6f26ahr 1156 18 and and CC cord-028721-x6f26ahr 1156 19 the the DT cord-028721-x6f26ahr 1156 20 base base NN cord-028721-x6f26ahr 1156 21 of of IN cord-028721-x6f26ahr 1156 22 the the DT cord-028721-x6f26ahr 1156 23 penis penis NN cord-028721-x6f26ahr 1156 24 . . . cord-028721-x6f26ahr 1157 1 Retractile Retractile NNP cord-028721-x6f26ahr 1157 2 testes testis NNS cord-028721-x6f26ahr 1157 3 may may MD cord-028721-x6f26ahr 1157 4 be be VB cord-028721-x6f26ahr 1157 5 moved move VBN cord-028721-x6f26ahr 1157 6 to to IN cord-028721-x6f26ahr 1157 7 the the DT cord-028721-x6f26ahr 1157 8 scrotum scrotum NN cord-028721-x6f26ahr 1157 9 at at IN cord-028721-x6f26ahr 1157 10 exploration exploration NN cord-028721-x6f26ahr 1157 11 and and CC cord-028721-x6f26ahr 1157 12 account account VBP cord-028721-x6f26ahr 1157 13 for for IN cord-028721-x6f26ahr 1157 14 about about RB cord-028721-x6f26ahr 1157 15 one one CD cord-028721-x6f26ahr 1157 16 third third NN cord-028721-x6f26ahr 1157 17 of of IN cord-028721-x6f26ahr 1157 18 undescended undescended JJ cord-028721-x6f26ahr 1157 19 testes testis NNS cord-028721-x6f26ahr 1157 20 . . . cord-028721-x6f26ahr 1158 1 Patients patient NNS cord-028721-x6f26ahr 1158 2 with with IN cord-028721-x6f26ahr 1158 3 true true JJ cord-028721-x6f26ahr 1158 4 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1158 5 account account NN cord-028721-x6f26ahr 1158 6 for for IN cord-028721-x6f26ahr 1158 7 about about RB cord-028721-x6f26ahr 1158 8 25 25 CD cord-028721-x6f26ahr 1158 9 % % NN cord-028721-x6f26ahr 1158 10 of of IN cord-028721-x6f26ahr 1158 11 cases case NNS cord-028721-x6f26ahr 1158 12 of of IN cord-028721-x6f26ahr 1158 13 empty empty JJ cord-028721-x6f26ahr 1158 14 scrotum scrotum NN cord-028721-x6f26ahr 1158 15 . . . cord-028721-x6f26ahr 1159 1 These these DT cord-028721-x6f26ahr 1159 2 testes testis NNS cord-028721-x6f26ahr 1159 3 most most RBS cord-028721-x6f26ahr 1159 4 frequently frequently RB cord-028721-x6f26ahr 1159 5 are be VBP cord-028721-x6f26ahr 1159 6 found find VBN cord-028721-x6f26ahr 1159 7 in in IN cord-028721-x6f26ahr 1159 8 the the DT cord-028721-x6f26ahr 1159 9 inguinal inguinal JJ cord-028721-x6f26ahr 1159 10 canal canal NN cord-028721-x6f26ahr 1159 11 or or CC cord-028721-x6f26ahr 1159 12 upper upper JJ cord-028721-x6f26ahr 1159 13 scrotum scrotum NN cord-028721-x6f26ahr 1159 14 ; ; : cord-028721-x6f26ahr 1159 15 arrest arrest NN cord-028721-x6f26ahr 1159 16 within within IN cord-028721-x6f26ahr 1159 17 the the DT cord-028721-x6f26ahr 1159 18 abdomen abdomen NN cord-028721-x6f26ahr 1159 19 is be VBZ cord-028721-x6f26ahr 1159 20 less less RBR cord-028721-x6f26ahr 1159 21 frequent frequent JJ cord-028721-x6f26ahr 1159 22 . . . cord-028721-x6f26ahr 1160 1 Cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1160 2 is be VBZ cord-028721-x6f26ahr 1160 3 slightly slightly RB cord-028721-x6f26ahr 1160 4 more more RBR cord-028721-x6f26ahr 1160 5 frequent frequent JJ cord-028721-x6f26ahr 1160 6 on on IN cord-028721-x6f26ahr 1160 7 the the DT cord-028721-x6f26ahr 1160 8 right right NN cord-028721-x6f26ahr 1160 9 than than IN cord-028721-x6f26ahr 1160 10 the the DT cord-028721-x6f26ahr 1160 11 left left NN cord-028721-x6f26ahr 1160 12 , , , cord-028721-x6f26ahr 1160 13 and and CC cord-028721-x6f26ahr 1160 14 in in IN cord-028721-x6f26ahr 1160 15 approximately approximately RB cord-028721-x6f26ahr 1160 16 18 18 CD cord-028721-x6f26ahr 1160 17 % % NN cord-028721-x6f26ahr 1160 18 of of IN cord-028721-x6f26ahr 1160 19 cases case NNS cord-028721-x6f26ahr 1160 20 is be VBZ cord-028721-x6f26ahr 1160 21 bilateral bilateral JJ cord-028721-x6f26ahr 1160 22 . . . cord-028721-x6f26ahr 1161 1 There there EX cord-028721-x6f26ahr 1161 2 is be VBZ cord-028721-x6f26ahr 1161 3 a a DT cord-028721-x6f26ahr 1161 4 family family NN cord-028721-x6f26ahr 1161 5 history history NN cord-028721-x6f26ahr 1161 6 of of IN cord-028721-x6f26ahr 1161 7 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1161 8 in in IN cord-028721-x6f26ahr 1161 9 14 14 CD cord-028721-x6f26ahr 1161 10 % % NN cord-028721-x6f26ahr 1161 11 of of IN cord-028721-x6f26ahr 1161 12 cases case NNS cord-028721-x6f26ahr 1161 13 . . . cord-028721-x6f26ahr 1162 1 495 495 CD cord-028721-x6f26ahr 1163 1 The the DT cord-028721-x6f26ahr 1163 2 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1163 3 testis testis NN cord-028721-x6f26ahr 1163 4 is be VBZ cord-028721-x6f26ahr 1163 5 usually usually RB cord-028721-x6f26ahr 1163 6 smaller small JJR cord-028721-x6f26ahr 1163 7 than than IN cord-028721-x6f26ahr 1163 8 the the DT cord-028721-x6f26ahr 1163 9 contralateral contralateral JJ cord-028721-x6f26ahr 1163 10 one one NN cord-028721-x6f26ahr 1163 11 , , , cord-028721-x6f26ahr 1163 12 and and CC cord-028721-x6f26ahr 1163 13 this this DT cord-028721-x6f26ahr 1163 14 difference difference NN cord-028721-x6f26ahr 1163 15 is be VBZ cord-028721-x6f26ahr 1163 16 often often RB cord-028721-x6f26ahr 1163 17 discernible discernible JJ cord-028721-x6f26ahr 1163 18 at at IN cord-028721-x6f26ahr 1163 19 6 6 CD cord-028721-x6f26ahr 1163 20 months month NNS cord-028721-x6f26ahr 1163 21 of of IN cord-028721-x6f26ahr 1163 22 age age NN cord-028721-x6f26ahr 1163 23 . . . cord-028721-x6f26ahr 1164 1 496 496 CD cord-028721-x6f26ahr 1165 1 One one CD cord-028721-x6f26ahr 1165 2 - - HYPH cord-028721-x6f26ahr 1165 3 third third NN cord-028721-x6f26ahr 1165 4 of of IN cord-028721-x6f26ahr 1165 5 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1165 6 testes testis NNS cord-028721-x6f26ahr 1165 7 are be VBP cord-028721-x6f26ahr 1165 8 soft soft JJ cord-028721-x6f26ahr 1165 9 . . . cord-028721-x6f26ahr 1166 1 Several several JJ cord-028721-x6f26ahr 1166 2 conditions condition NNS cord-028721-x6f26ahr 1166 3 are be VBP cord-028721-x6f26ahr 1166 4 predictive predictive JJ cord-028721-x6f26ahr 1166 5 of of IN cord-028721-x6f26ahr 1166 6 high high JJ cord-028721-x6f26ahr 1166 7 risk risk NN cord-028721-x6f26ahr 1166 8 of of IN cord-028721-x6f26ahr 1166 9 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1166 10 , , , cord-028721-x6f26ahr 1166 11 including include VBG cord-028721-x6f26ahr 1166 12 increased increase VBN cord-028721-x6f26ahr 1166 13 maternal maternal JJ cord-028721-x6f26ahr 1166 14 age age NN cord-028721-x6f26ahr 1166 15 , , , cord-028721-x6f26ahr 1166 16 maternal maternal JJ cord-028721-x6f26ahr 1166 17 obesity obesity NN cord-028721-x6f26ahr 1166 18 , , , cord-028721-x6f26ahr 1166 19 pregnancy pregnancy NN cord-028721-x6f26ahr 1166 20 toxemia toxemia NN cord-028721-x6f26ahr 1166 21 , , , cord-028721-x6f26ahr 1166 22 bleeding bleed VBG cord-028721-x6f26ahr 1166 23 during during IN cord-028721-x6f26ahr 1166 24 late late JJ cord-028721-x6f26ahr 1166 25 pregnancy pregnancy NN cord-028721-x6f26ahr 1166 26 , , , cord-028721-x6f26ahr 1166 27 and and CC cord-028721-x6f26ahr 1166 28 smoking smoking NN cord-028721-x6f26ahr 1166 29 , , , cord-028721-x6f26ahr 1166 30 tallness tallness NN cord-028721-x6f26ahr 1166 31 , , , cord-028721-x6f26ahr 1166 32 subfertility subfertility NN cord-028721-x6f26ahr 1166 33 antecedents antecedent NNS cord-028721-x6f26ahr 1166 34 , , , cord-028721-x6f26ahr 1166 35 cesarean cesarean NN cord-028721-x6f26ahr 1166 36 birth birth NN cord-028721-x6f26ahr 1166 37 , , , cord-028721-x6f26ahr 1166 38 low low JJ cord-028721-x6f26ahr 1166 39 birthweight birthweight JJ cord-028721-x6f26ahr 1166 40 , , , cord-028721-x6f26ahr 1166 41 preterm preterm NNS cord-028721-x6f26ahr 1166 42 newborn newborn JJ cord-028721-x6f26ahr 1166 43 , , , cord-028721-x6f26ahr 1166 44 twin twin JJ cord-028721-x6f26ahr 1166 45 birth birth NN cord-028721-x6f26ahr 1166 46 , , , cord-028721-x6f26ahr 1166 47 hypospadias hypospadia NNS cord-028721-x6f26ahr 1166 48 497 497 CD cord-028721-x6f26ahr 1166 49 and and CC cord-028721-x6f26ahr 1166 50 other other JJ cord-028721-x6f26ahr 1166 51 congenital congenital JJ cord-028721-x6f26ahr 1166 52 malformations malformation NNS cord-028721-x6f26ahr 1166 53 , , , cord-028721-x6f26ahr 1166 54 and and CC cord-028721-x6f26ahr 1166 55 children child NNS cord-028721-x6f26ahr 1166 56 born bear VBN cord-028721-x6f26ahr 1166 57 from from IN cord-028721-x6f26ahr 1166 58 September September NNP cord-028721-x6f26ahr 1166 59 to to IN cord-028721-x6f26ahr 1166 60 November November NNP cord-028721-x6f26ahr 1166 61 , , , cord-028721-x6f26ahr 1166 62 and and CC cord-028721-x6f26ahr 1166 63 in in IN cord-028721-x6f26ahr 1166 64 May May NNP cord-028721-x6f26ahr 1166 65 and and CC cord-028721-x6f26ahr 1166 66 June June NNP cord-028721-x6f26ahr 1166 67 . . . cord-028721-x6f26ahr 1167 1 498 498 CD cord-028721-x6f26ahr 1167 2 , , , cord-028721-x6f26ahr 1167 3 499 499 CD cord-028721-x6f26ahr 1167 4 Of of IN cord-028721-x6f26ahr 1167 5 these these DT cord-028721-x6f26ahr 1167 6 associations association NNS cord-028721-x6f26ahr 1167 7 , , , cord-028721-x6f26ahr 1167 8 low low JJ cord-028721-x6f26ahr 1167 9 birth birth NN cord-028721-x6f26ahr 1167 10 weight weight NN cord-028721-x6f26ahr 1167 11 seems seem VBZ cord-028721-x6f26ahr 1167 12 to to TO cord-028721-x6f26ahr 1167 13 be be VB cord-028721-x6f26ahr 1167 14 the the DT cord-028721-x6f26ahr 1167 15 most most RBS cord-028721-x6f26ahr 1167 16 important important JJ cord-028721-x6f26ahr 1167 17 . . . cord-028721-x6f26ahr 1168 1 500 500 CD cord-028721-x6f26ahr 1169 1 There there EX cord-028721-x6f26ahr 1169 2 are be VBP cord-028721-x6f26ahr 1169 3 two two CD cord-028721-x6f26ahr 1169 4 types type NNS cord-028721-x6f26ahr 1169 5 of of IN cord-028721-x6f26ahr 1169 6 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1169 7 : : : cord-028721-x6f26ahr 1170 1 congenital congenital JJ cord-028721-x6f26ahr 1170 2 and and CC cord-028721-x6f26ahr 1170 3 acquired acquire VBD cord-028721-x6f26ahr 1170 4 . . . cord-028721-x6f26ahr 1171 1 This this DT cord-028721-x6f26ahr 1171 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1171 3 is be VBZ cord-028721-x6f26ahr 1171 4 caused cause VBN cord-028721-x6f26ahr 1171 5 by by IN cord-028721-x6f26ahr 1171 6 anomalies anomaly NNS cord-028721-x6f26ahr 1171 7 in in IN cord-028721-x6f26ahr 1171 8 anatomic anatomic JJ cord-028721-x6f26ahr 1171 9 development development NN cord-028721-x6f26ahr 1171 10 or or CC cord-028721-x6f26ahr 1171 11 hormonal hormonal JJ cord-028721-x6f26ahr 1171 12 mechanisms mechanism NNS cord-028721-x6f26ahr 1171 13 involved involve VBN cord-028721-x6f26ahr 1171 14 in in IN cord-028721-x6f26ahr 1171 15 testicular testicular JJ cord-028721-x6f26ahr 1171 16 descent descent NN cord-028721-x6f26ahr 1171 17 ( ( -LRB- cord-028721-x6f26ahr 1171 18 described describe VBN cord-028721-x6f26ahr 1171 19 above above RB cord-028721-x6f26ahr 1171 20 ) ) -RRB- cord-028721-x6f26ahr 1171 21 . . . cord-028721-x6f26ahr 1172 1 Impalpable impalpable JJ cord-028721-x6f26ahr 1172 2 undescended undescended JJ cord-028721-x6f26ahr 1172 3 testes testis NNS cord-028721-x6f26ahr 1172 4 are be VBP cord-028721-x6f26ahr 1172 5 infrequent infrequent JJ cord-028721-x6f26ahr 1172 6 because because IN cord-028721-x6f26ahr 1172 7 the the DT cord-028721-x6f26ahr 1172 8 transabdominal transabdominal JJ cord-028721-x6f26ahr 1172 9 phase phase NN cord-028721-x6f26ahr 1172 10 follows follow VBZ cord-028721-x6f26ahr 1172 11 the the DT cord-028721-x6f26ahr 1172 12 simple simple JJ cord-028721-x6f26ahr 1172 13 mechanism mechanism NN cord-028721-x6f26ahr 1172 14 of of IN cord-028721-x6f26ahr 1172 15 relative relative JJ cord-028721-x6f26ahr 1172 16 movement movement NN cord-028721-x6f26ahr 1172 17 of of IN cord-028721-x6f26ahr 1172 18 the the DT cord-028721-x6f26ahr 1172 19 testis testis NN cord-028721-x6f26ahr 1172 20 , , , cord-028721-x6f26ahr 1172 21 whereas whereas IN cord-028721-x6f26ahr 1172 22 displacement displacement NN cord-028721-x6f26ahr 1172 23 of of IN cord-028721-x6f26ahr 1172 24 the the DT cord-028721-x6f26ahr 1172 25 ovary ovary NN cord-028721-x6f26ahr 1172 26 is be VBZ cord-028721-x6f26ahr 1172 27 more more RBR cord-028721-x6f26ahr 1172 28 complex complex JJ cord-028721-x6f26ahr 1172 29 . . . cord-028721-x6f26ahr 1173 1 501 501 CD cord-028721-x6f26ahr 1174 1 Conversely conversely RB cord-028721-x6f26ahr 1174 2 , , , cord-028721-x6f26ahr 1174 3 palpable palpable JJ cord-028721-x6f26ahr 1174 4 undescended undescended JJ cord-028721-x6f26ahr 1174 5 testes testis NNS cord-028721-x6f26ahr 1174 6 are be VBP cord-028721-x6f26ahr 1174 7 more more RBR cord-028721-x6f26ahr 1174 8 frequent frequent JJ cord-028721-x6f26ahr 1174 9 because because IN cord-028721-x6f26ahr 1174 10 the the DT cord-028721-x6f26ahr 1174 11 second second JJ cord-028721-x6f26ahr 1174 12 phase phase NN cord-028721-x6f26ahr 1174 13 of of IN cord-028721-x6f26ahr 1174 14 testicular testicular JJ cord-028721-x6f26ahr 1174 15 descent descent NN cord-028721-x6f26ahr 1174 16 is be VBZ cord-028721-x6f26ahr 1174 17 more more RBR cord-028721-x6f26ahr 1174 18 complex complex JJ cord-028721-x6f26ahr 1174 19 . . . cord-028721-x6f26ahr 1175 1 Unilateral unilateral JJ cord-028721-x6f26ahr 1175 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1175 3 may may MD cord-028721-x6f26ahr 1175 4 be be VB cord-028721-x6f26ahr 1175 5 caused cause VBN cord-028721-x6f26ahr 1175 6 by by IN cord-028721-x6f26ahr 1175 7 androgen androgen NN cord-028721-x6f26ahr 1175 8 failure failure NN cord-028721-x6f26ahr 1175 9 , , , cord-028721-x6f26ahr 1175 10 which which WDT cord-028721-x6f26ahr 1175 11 leads lead VBZ cord-028721-x6f26ahr 1175 12 to to IN cord-028721-x6f26ahr 1175 13 either either CC cord-028721-x6f26ahr 1175 14 an an DT cord-028721-x6f26ahr 1175 15 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 1175 16 lesion lesion NN cord-028721-x6f26ahr 1175 17 in in IN cord-028721-x6f26ahr 1175 18 the the DT cord-028721-x6f26ahr 1175 19 development development NN cord-028721-x6f26ahr 1175 20 of of IN cord-028721-x6f26ahr 1175 21 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 1175 22 nerve nerve NN cord-028721-x6f26ahr 1175 23 neurons neuron NNS cord-028721-x6f26ahr 1175 24 or or CC cord-028721-x6f26ahr 1175 25 a a DT cord-028721-x6f26ahr 1175 26 defect defect NN cord-028721-x6f26ahr 1175 27 in in IN cord-028721-x6f26ahr 1175 28 CGRP cgrp NN cord-028721-x6f26ahr 1175 29 release release NN cord-028721-x6f26ahr 1175 30 that that WDT cord-028721-x6f26ahr 1175 31 hinders hinder VBZ cord-028721-x6f26ahr 1175 32 normal normal JJ cord-028721-x6f26ahr 1175 33 migration migration NN cord-028721-x6f26ahr 1175 34 of of IN cord-028721-x6f26ahr 1175 35 the the DT cord-028721-x6f26ahr 1175 36 gubernaculum gubernaculum NN cord-028721-x6f26ahr 1175 37 . . . cord-028721-x6f26ahr 1176 1 A a DT cord-028721-x6f26ahr 1176 2 normally normally RB cord-028721-x6f26ahr 1176 3 descended descend VBN cord-028721-x6f26ahr 1176 4 testis testis NN cord-028721-x6f26ahr 1176 5 may may MD cord-028721-x6f26ahr 1176 6 become become VB cord-028721-x6f26ahr 1176 7 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1176 8 and and CC cord-028721-x6f26ahr 1176 9 locate locate VB cord-028721-x6f26ahr 1176 10 even even RB cord-028721-x6f26ahr 1176 11 in in IN cord-028721-x6f26ahr 1176 12 the the DT cord-028721-x6f26ahr 1176 13 abdominal abdominal JJ cord-028721-x6f26ahr 1176 14 cavity cavity NN cord-028721-x6f26ahr 1176 15 . . . cord-028721-x6f26ahr 1177 1 Two two CD cord-028721-x6f26ahr 1177 2 categories category NNS cord-028721-x6f26ahr 1177 3 of of IN cord-028721-x6f26ahr 1177 4 acquired acquire VBN cord-028721-x6f26ahr 1177 5 undescended undescended JJ cord-028721-x6f26ahr 1177 6 testis testis NN cord-028721-x6f26ahr 1177 7 have have VBP cord-028721-x6f26ahr 1177 8 been be VBN cord-028721-x6f26ahr 1177 9 described describe VBN cord-028721-x6f26ahr 1177 10 . . . cord-028721-x6f26ahr 1178 1 The the DT cord-028721-x6f26ahr 1178 2 postoperative postoperative JJ cord-028721-x6f26ahr 1178 3 trapped trap VBN cord-028721-x6f26ahr 1178 4 testis testis NN cord-028721-x6f26ahr 1178 5 502 502 CD cord-028721-x6f26ahr 1178 6 is be VBZ cord-028721-x6f26ahr 1178 7 a a DT cord-028721-x6f26ahr 1178 8 normally normally RB cord-028721-x6f26ahr 1178 9 descended descend VBN cord-028721-x6f26ahr 1178 10 testis testis NN cord-028721-x6f26ahr 1178 11 that that WDT cord-028721-x6f26ahr 1178 12 leaves leave VBZ cord-028721-x6f26ahr 1178 13 the the DT cord-028721-x6f26ahr 1178 14 scrotal scrotal JJ cord-028721-x6f26ahr 1178 15 pouch pouch NN cord-028721-x6f26ahr 1178 16 after after IN cord-028721-x6f26ahr 1178 17 surgery surgery NN cord-028721-x6f26ahr 1178 18 owing owe VBG cord-028721-x6f26ahr 1178 19 to to IN cord-028721-x6f26ahr 1178 20 an an DT cord-028721-x6f26ahr 1178 21 inguinal inguinal JJ cord-028721-x6f26ahr 1178 22 hernia hernia NN cord-028721-x6f26ahr 1178 23 or or CC cord-028721-x6f26ahr 1178 24 hydrocele hydrocele NN cord-028721-x6f26ahr 1178 25 . . . cord-028721-x6f26ahr 1179 1 [ [ -LRB- cord-028721-x6f26ahr 1179 2 503 503 CD cord-028721-x6f26ahr 1179 3 ] ] -RRB- cord-028721-x6f26ahr 1179 4 [ [ -LRB- cord-028721-x6f26ahr 1179 5 504 504 CD cord-028721-x6f26ahr 1179 6 ] ] -RRB- cord-028721-x6f26ahr 1180 1 [ [ -LRB- cord-028721-x6f26ahr 1180 2 505 505 CD cord-028721-x6f26ahr 1180 3 ] ] -RRB- cord-028721-x6f26ahr 1181 1 This this DT cord-028721-x6f26ahr 1181 2 iatrogenic iatrogenic JJ cord-028721-x6f26ahr 1181 3 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1181 4 occurs occur VBZ cord-028721-x6f26ahr 1181 5 in in IN cord-028721-x6f26ahr 1181 6 1.2 1.2 CD cord-028721-x6f26ahr 1181 7 % % NN cord-028721-x6f26ahr 1181 8 of of IN cord-028721-x6f26ahr 1181 9 children child NNS cord-028721-x6f26ahr 1181 10 after after IN cord-028721-x6f26ahr 1181 11 herniotomy herniotomy NN cord-028721-x6f26ahr 1181 12 . . . cord-028721-x6f26ahr 1182 1 Adherence adherence NN cord-028721-x6f26ahr 1182 2 of of IN cord-028721-x6f26ahr 1182 3 the the DT cord-028721-x6f26ahr 1182 4 testis testis NN cord-028721-x6f26ahr 1182 5 or or CC cord-028721-x6f26ahr 1182 6 the the DT cord-028721-x6f26ahr 1182 7 cremasteric cremasteric JJ cord-028721-x6f26ahr 1182 8 muscle muscle NN cord-028721-x6f26ahr 1182 9 to to IN cord-028721-x6f26ahr 1182 10 the the DT cord-028721-x6f26ahr 1182 11 surgical surgical JJ cord-028721-x6f26ahr 1182 12 incision incision NN cord-028721-x6f26ahr 1182 13 causes cause VBZ cord-028721-x6f26ahr 1182 14 testicular testicular NN cord-028721-x6f26ahr 1182 15 ascent ascent NN cord-028721-x6f26ahr 1182 16 when when WRB cord-028721-x6f26ahr 1182 17 the the DT cord-028721-x6f26ahr 1182 18 incision incision NN cord-028721-x6f26ahr 1182 19 heals heal VBZ cord-028721-x6f26ahr 1182 20 and and CC cord-028721-x6f26ahr 1182 21 undergoes undergo VBZ cord-028721-x6f26ahr 1182 22 retraction retraction NN cord-028721-x6f26ahr 1182 23 . . . cord-028721-x6f26ahr 1183 1 Spontaneous spontaneous JJ cord-028721-x6f26ahr 1183 2 ascent ascent NN cord-028721-x6f26ahr 1183 3 from from IN cord-028721-x6f26ahr 1183 4 unknown unknown JJ cord-028721-x6f26ahr 1183 5 causes cause NNS cord-028721-x6f26ahr 1183 6 . . . cord-028721-x6f26ahr 1184 1 Various various JJ cord-028721-x6f26ahr 1184 2 mechanisms mechanism NNS cord-028721-x6f26ahr 1184 3 have have VBP cord-028721-x6f26ahr 1184 4 been be VBN cord-028721-x6f26ahr 1184 5 proposed propose VBN cord-028721-x6f26ahr 1184 6 , , , cord-028721-x6f26ahr 1184 7 including include VBG cord-028721-x6f26ahr 1184 8 inability inability NN cord-028721-x6f26ahr 1184 9 of of IN cord-028721-x6f26ahr 1184 10 the the DT cord-028721-x6f26ahr 1184 11 spermatic spermatic JJ cord-028721-x6f26ahr 1184 12 blood blood NN cord-028721-x6f26ahr 1184 13 vessels vessel NNS cord-028721-x6f26ahr 1184 14 to to TO cord-028721-x6f26ahr 1184 15 grow grow VB cord-028721-x6f26ahr 1184 16 adequately adequately RB cord-028721-x6f26ahr 1184 17 , , , cord-028721-x6f26ahr 1184 18 506 506 CD cord-028721-x6f26ahr 1184 19 anomalous anomalous JJ cord-028721-x6f26ahr 1184 20 insertion insertion NN cord-028721-x6f26ahr 1184 21 of of IN cord-028721-x6f26ahr 1184 22 the the DT cord-028721-x6f26ahr 1184 23 gubernaculum gubernaculum NN cord-028721-x6f26ahr 1184 24 , , , cord-028721-x6f26ahr 1184 25 507 507 CD cord-028721-x6f26ahr 1184 26 failure failure NN cord-028721-x6f26ahr 1184 27 in in IN cord-028721-x6f26ahr 1184 28 reabsorption reabsorption NN cord-028721-x6f26ahr 1184 29 of of IN cord-028721-x6f26ahr 1184 30 the the DT cord-028721-x6f26ahr 1184 31 vaginal vaginal JJ cord-028721-x6f26ahr 1184 32 process process NN cord-028721-x6f26ahr 1184 33 508 508 CD cord-028721-x6f26ahr 1184 34 , , , cord-028721-x6f26ahr 1184 35 509 509 CD cord-028721-x6f26ahr 1184 36 and and CC cord-028721-x6f26ahr 1184 37 failure failure NN cord-028721-x6f26ahr 1184 38 in in IN cord-028721-x6f26ahr 1184 39 postnatal postnatal JJ cord-028721-x6f26ahr 1184 40 elongation elongation NN cord-028721-x6f26ahr 1184 41 of of IN cord-028721-x6f26ahr 1184 42 the the DT cord-028721-x6f26ahr 1184 43 spermatic spermatic JJ cord-028721-x6f26ahr 1184 44 cord cord NN cord-028721-x6f26ahr 1184 45 . . . cord-028721-x6f26ahr 1185 1 510 510 CD cord-028721-x6f26ahr 1185 2 , , , cord-028721-x6f26ahr 1185 3 511 511 CD cord-028721-x6f26ahr 1186 1 The the DT cord-028721-x6f26ahr 1186 2 spermatic spermatic JJ cord-028721-x6f26ahr 1186 3 cord cord NN cord-028721-x6f26ahr 1186 4 measures measure NNS cord-028721-x6f26ahr 1186 5 4 4 CD cord-028721-x6f26ahr 1186 6 - - SYM cord-028721-x6f26ahr 1186 7 5 5 CD cord-028721-x6f26ahr 1186 8 cm cm NNS cord-028721-x6f26ahr 1186 9 at at IN cord-028721-x6f26ahr 1186 10 birth birth NN cord-028721-x6f26ahr 1186 11 and and CC cord-028721-x6f26ahr 1186 12 reaches reach VBZ cord-028721-x6f26ahr 1186 13 8 8 CD cord-028721-x6f26ahr 1186 14 - - SYM cord-028721-x6f26ahr 1186 15 10 10 CD cord-028721-x6f26ahr 1186 16 cm cm NNS cord-028721-x6f26ahr 1186 17 at at IN cord-028721-x6f26ahr 1186 18 10 10 CD cord-028721-x6f26ahr 1186 19 years year NNS cord-028721-x6f26ahr 1186 20 of of IN cord-028721-x6f26ahr 1186 21 age age NN cord-028721-x6f26ahr 1186 22 . . . cord-028721-x6f26ahr 1187 1 This this DT cord-028721-x6f26ahr 1187 2 growth growth NN cord-028721-x6f26ahr 1187 3 does do VBZ cord-028721-x6f26ahr 1187 4 not not RB cord-028721-x6f26ahr 1187 5 occur occur VB cord-028721-x6f26ahr 1187 6 if if IN cord-028721-x6f26ahr 1187 7 the the DT cord-028721-x6f26ahr 1187 8 peritoneal peritoneal JJ cord-028721-x6f26ahr 1187 9 - - HYPH cord-028721-x6f26ahr 1187 10 vaginal vaginal JJ cord-028721-x6f26ahr 1187 11 duct duct NN cord-028721-x6f26ahr 1187 12 has have VBZ cord-028721-x6f26ahr 1187 13 become become VBN cord-028721-x6f26ahr 1187 14 a a DT cord-028721-x6f26ahr 1187 15 fi fi NN cord-028721-x6f26ahr 1187 16 brous brous JJ cord-028721-x6f26ahr 1187 17 remnant remnant NN cord-028721-x6f26ahr 1187 18 . . . cord-028721-x6f26ahr 1188 1 The the DT cord-028721-x6f26ahr 1188 2 cause cause NN cord-028721-x6f26ahr 1188 3 might may MD cord-028721-x6f26ahr 1188 4 be be VB cord-028721-x6f26ahr 1188 5 a a DT cord-028721-x6f26ahr 1188 6 defect defect NN cord-028721-x6f26ahr 1188 7 in in IN cord-028721-x6f26ahr 1188 8 postnatal postnatal JJ cord-028721-x6f26ahr 1188 9 CGRP cgrp NN cord-028721-x6f26ahr 1188 10 release release NN cord-028721-x6f26ahr 1188 11 by by IN cord-028721-x6f26ahr 1188 12 the the DT cord-028721-x6f26ahr 1188 13 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 1188 14 nerve nerve NN cord-028721-x6f26ahr 1188 15 . . . cord-028721-x6f26ahr 1189 1 501 501 CD cord-028721-x6f26ahr 1189 2 , , , cord-028721-x6f26ahr 1189 3 512 512 CD cord-028721-x6f26ahr 1190 1 , , , cord-028721-x6f26ahr 1190 2 513 513 CD cord-028721-x6f26ahr 1190 3 Pathogenesis pathogenesis NN cord-028721-x6f26ahr 1191 1 The the DT cord-028721-x6f26ahr 1191 2 most most RBS cord-028721-x6f26ahr 1191 3 frequent frequent JJ cord-028721-x6f26ahr 1191 4 fi fi NN cord-028721-x6f26ahr 1191 5 ndings nding NNS cord-028721-x6f26ahr 1191 6 in in IN cord-028721-x6f26ahr 1191 7 congenital congenital JJ cord-028721-x6f26ahr 1191 8 and and CC cord-028721-x6f26ahr 1191 9 acquired acquire VBD cord-028721-x6f26ahr 1191 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1191 11 at at IN cord-028721-x6f26ahr 1191 12 infancy infancy NN cord-028721-x6f26ahr 1191 13 are be VBP cord-028721-x6f26ahr 1191 14 decreased decrease VBN cord-028721-x6f26ahr 1191 15 germ germ NN cord-028721-x6f26ahr 1191 16 cell cell NN cord-028721-x6f26ahr 1191 17 numbers number NNS cord-028721-x6f26ahr 1191 18 and and CC cord-028721-x6f26ahr 1191 19 diminished diminish VBD cord-028721-x6f26ahr 1191 20 tubular tubular JJ cord-028721-x6f26ahr 1191 21 diameter diameter NN cord-028721-x6f26ahr 1191 22 . . . cord-028721-x6f26ahr 1192 1 514 514 CD cord-028721-x6f26ahr 1192 2 , , , cord-028721-x6f26ahr 1192 3 515 515 CD cord-028721-x6f26ahr 1192 4 There there EX cord-028721-x6f26ahr 1192 5 are be VBP cord-028721-x6f26ahr 1192 6 multiple multiple JJ cord-028721-x6f26ahr 1192 7 causes cause NNS cord-028721-x6f26ahr 1192 8 of of IN cord-028721-x6f26ahr 1192 9 testicular testicular JJ cord-028721-x6f26ahr 1192 10 maldescent maldescent NN cord-028721-x6f26ahr 1192 11 , , , cord-028721-x6f26ahr 1192 12 including include VBG cord-028721-x6f26ahr 1192 13 anatomical anatomical JJ cord-028721-x6f26ahr 1192 14 anomalies anomaly NNS cord-028721-x6f26ahr 1192 15 of of IN cord-028721-x6f26ahr 1192 16 the the DT cord-028721-x6f26ahr 1192 17 gubernaculum gubernaculum NN cord-028721-x6f26ahr 1192 18 testis testis NN cord-028721-x6f26ahr 1192 19 , , , cord-028721-x6f26ahr 1192 20 hormonal hormonal JJ cord-028721-x6f26ahr 1192 21 dysfunction dysfunction NN cord-028721-x6f26ahr 1192 22 ( ( -LRB- cord-028721-x6f26ahr 1192 23 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 1192 24 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 1192 25 ) ) -RRB- cord-028721-x6f26ahr 1192 26 , , , cord-028721-x6f26ahr 1192 27 mechanical mechanical JJ cord-028721-x6f26ahr 1192 28 impairment impairment NN cord-028721-x6f26ahr 1192 29 ( ( -LRB- cord-028721-x6f26ahr 1192 30 insuffi insuffi NNP cord-028721-x6f26ahr 1192 31 cient cient NNP cord-028721-x6f26ahr 1192 32 intra intra JJ cord-028721-x6f26ahr 1192 33 - - JJ cord-028721-x6f26ahr 1192 34 abdominal abdominal JJ cord-028721-x6f26ahr 1192 35 pressure pressure NN cord-028721-x6f26ahr 1192 36 , , , cord-028721-x6f26ahr 1192 37 short short JJ cord-028721-x6f26ahr 1192 38 spermatic spermatic JJ cord-028721-x6f26ahr 1192 39 cord cord NN cord-028721-x6f26ahr 1192 40 , , , cord-028721-x6f26ahr 1192 41 underdeveloped underdeveloped JJ cord-028721-x6f26ahr 1192 42 processus processus NNP cord-028721-x6f26ahr 1192 43 vaginalis vaginalis NN cord-028721-x6f26ahr 1192 44 ) ) -RRB- cord-028721-x6f26ahr 1192 45 , , , cord-028721-x6f26ahr 1192 46 dysgenetic dysgenetic NNP cord-028721-x6f26ahr 1192 47 ( ( -LRB- cord-028721-x6f26ahr 1192 48 primary primary JJ cord-028721-x6f26ahr 1192 49 anomaly anomaly NN cord-028721-x6f26ahr 1192 50 of of IN cord-028721-x6f26ahr 1192 51 the the DT cord-028721-x6f26ahr 1192 52 testis testis NN cord-028721-x6f26ahr 1192 53 ) ) -RRB- cord-028721-x6f26ahr 1192 54 , , , cord-028721-x6f26ahr 1192 55 and and CC cord-028721-x6f26ahr 1192 56 heredity heredity NN cord-028721-x6f26ahr 1192 57 . . . cord-028721-x6f26ahr 1193 1 Most Most JJS cord-028721-x6f26ahr 1193 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1193 3 appears appear VBZ cord-028721-x6f26ahr 1193 4 to to TO cord-028721-x6f26ahr 1193 5 be be VB cord-028721-x6f26ahr 1193 6 caused cause VBN cord-028721-x6f26ahr 1193 7 by by IN cord-028721-x6f26ahr 1193 8 either either CC cord-028721-x6f26ahr 1193 9 a a DT cord-028721-x6f26ahr 1193 10 defi defi NNP cord-028721-x6f26ahr 1193 11 cit cit NN cord-028721-x6f26ahr 1193 12 of of IN cord-028721-x6f26ahr 1193 13 fetal fetal JJ cord-028721-x6f26ahr 1193 14 androgens androgen NNS cord-028721-x6f26ahr 1193 15 or or CC cord-028721-x6f26ahr 1193 16 an an DT cord-028721-x6f26ahr 1193 17 excess excess NN cord-028721-x6f26ahr 1193 18 of of IN cord-028721-x6f26ahr 1193 19 maternal maternal JJ cord-028721-x6f26ahr 1193 20 estrogens estrogen NNS cord-028721-x6f26ahr 1193 21 . . . cord-028721-x6f26ahr 1194 1 Androgen Androgen NNP cord-028721-x6f26ahr 1194 2 insuffi insuffi NNP cord-028721-x6f26ahr 1194 3 ciency ciency NN cord-028721-x6f26ahr 1194 4 seems seem VBZ cord-028721-x6f26ahr 1194 5 to to TO cord-028721-x6f26ahr 1194 6 be be VB cord-028721-x6f26ahr 1194 7 slight slight JJ cord-028721-x6f26ahr 1194 8 and and CC cord-028721-x6f26ahr 1194 9 transient transient JJ cord-028721-x6f26ahr 1194 10 because because IN cord-028721-x6f26ahr 1194 11 anomalies anomaly NNS cord-028721-x6f26ahr 1194 12 other other JJ cord-028721-x6f26ahr 1194 13 than than IN cord-028721-x6f26ahr 1194 14 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1194 15 of of IN cord-028721-x6f26ahr 1194 16 the the DT cord-028721-x6f26ahr 1194 17 epididymis epididymis NN cord-028721-x6f26ahr 1194 18 are be VBP cord-028721-x6f26ahr 1194 19 not not RB cord-028721-x6f26ahr 1194 20 seen see VBN cord-028721-x6f26ahr 1194 21 . . . cord-028721-x6f26ahr 1195 1 Elevated elevated JJ cord-028721-x6f26ahr 1195 2 maternal maternal JJ cord-028721-x6f26ahr 1195 3 estrogens estrogen NNS cord-028721-x6f26ahr 1195 4 level level NN cord-028721-x6f26ahr 1195 5 could could MD cord-028721-x6f26ahr 1195 6 cause cause VB cord-028721-x6f26ahr 1195 7 diminution diminution NN cord-028721-x6f26ahr 1195 8 of of IN cord-028721-x6f26ahr 1195 9 FSH fsh NN cord-028721-x6f26ahr 1195 10 secretion secretion NN cord-028721-x6f26ahr 1195 11 by by IN cord-028721-x6f26ahr 1195 12 the the DT cord-028721-x6f26ahr 1195 13 fetal fetal JJ cord-028721-x6f26ahr 1195 14 pituitary pituitary NN cord-028721-x6f26ahr 1195 15 , , , cord-028721-x6f26ahr 1195 16 inducing induce VBG cord-028721-x6f26ahr 1195 17 low low JJ cord-028721-x6f26ahr 1195 18 müllerian müllerian NN cord-028721-x6f26ahr 1195 19 - - HYPH cord-028721-x6f26ahr 1195 20 inhibiting inhibit VBG cord-028721-x6f26ahr 1195 21 hormone hormone NN cord-028721-x6f26ahr 1195 22 production production NN cord-028721-x6f26ahr 1195 23 that that WDT cord-028721-x6f26ahr 1195 24 would would MD cord-028721-x6f26ahr 1195 25 hinder hinder VB cord-028721-x6f26ahr 1195 26 testicular testicular JJ cord-028721-x6f26ahr 1195 27 descent descent NN cord-028721-x6f26ahr 1195 28 . . . cord-028721-x6f26ahr 1196 1 516 516 CD cord-028721-x6f26ahr 1196 2 Three three CD cord-028721-x6f26ahr 1196 3 mechanisms mechanism NNS cord-028721-x6f26ahr 1196 4 seem seem VBP cord-028721-x6f26ahr 1196 5 to to TO cord-028721-x6f26ahr 1196 6 be be VB cord-028721-x6f26ahr 1196 7 involved involve VBN cord-028721-x6f26ahr 1196 8 in in IN cord-028721-x6f26ahr 1196 9 the the DT cord-028721-x6f26ahr 1196 10 process process NN cord-028721-x6f26ahr 1196 11 : : : cord-028721-x6f26ahr 1196 12 • • XX cord-028721-x6f26ahr 1197 1 Primary primary JJ cord-028721-x6f26ahr 1197 2 testicular testicular NN cord-028721-x6f26ahr 1197 3 anomaly anomaly NN cord-028721-x6f26ahr 1197 4 . . . cord-028721-x6f26ahr 1198 1 Cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1198 2 testes testis NNS cord-028721-x6f26ahr 1198 3 may may MD cord-028721-x6f26ahr 1198 4 bear bear VB cord-028721-x6f26ahr 1198 5 an an DT cord-028721-x6f26ahr 1198 6 anomalous anomalous JJ cord-028721-x6f26ahr 1198 7 germ germ NN cord-028721-x6f26ahr 1198 8 cell cell NN cord-028721-x6f26ahr 1198 9 population population NN cord-028721-x6f26ahr 1198 10 , , , cord-028721-x6f26ahr 1198 11 as as IN cord-028721-x6f26ahr 1198 12 suggested suggest VBD cord-028721-x6f26ahr 1198 13 many many JJ cord-028721-x6f26ahr 1198 14 years year NNS cord-028721-x6f26ahr 1198 15 ago ago RB cord-028721-x6f26ahr 1198 16 . . . cord-028721-x6f26ahr 1199 1 517 517 CD cord-028721-x6f26ahr 1199 2 More More JJR cord-028721-x6f26ahr 1199 3 than than IN cord-028721-x6f26ahr 1199 4 40 40 CD cord-028721-x6f26ahr 1199 5 % % NN cord-028721-x6f26ahr 1199 6 of of IN cord-028721-x6f26ahr 1199 7 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1199 8 patients patient NNS cord-028721-x6f26ahr 1199 9 have have VBP cord-028721-x6f26ahr 1199 10 a a DT cord-028721-x6f26ahr 1199 11 marked marked JJ cord-028721-x6f26ahr 1199 12 decrease decrease NN cord-028721-x6f26ahr 1199 13 in in IN cord-028721-x6f26ahr 1199 14 the the DT cord-028721-x6f26ahr 1199 15 tubular tubular JJ cord-028721-x6f26ahr 1199 16 fertility fertility NN cord-028721-x6f26ahr 1199 17 index index NN cord-028721-x6f26ahr 1199 18 , , , cord-028721-x6f26ahr 1199 19 518 518 CD cord-028721-x6f26ahr 1200 1 In in IN cord-028721-x6f26ahr 1200 2 the the DT cord-028721-x6f26ahr 1200 3 normal normal JJ cord-028721-x6f26ahr 1200 4 testis testis NN cord-028721-x6f26ahr 1200 5 there there EX cord-028721-x6f26ahr 1200 6 is be VBZ cord-028721-x6f26ahr 1200 7 transient transient JJ cord-028721-x6f26ahr 1200 8 formation formation NN cord-028721-x6f26ahr 1200 9 of of IN cord-028721-x6f26ahr 1200 10 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 1200 11 at at IN cord-028721-x6f26ahr 1200 12 4 4 CD cord-028721-x6f26ahr 1200 13 - - SYM cord-028721-x6f26ahr 1200 14 5 5 CD cord-028721-x6f26ahr 1200 15 years year NNS cord-028721-x6f26ahr 1200 16 of of IN cord-028721-x6f26ahr 1200 17 age age NN cord-028721-x6f26ahr 1200 18 . . . cord-028721-x6f26ahr 1201 1 This this DT cord-028721-x6f26ahr 1201 2 meiotic meiotic JJ cord-028721-x6f26ahr 1201 3 attempt attempt NN cord-028721-x6f26ahr 1201 4 is be VBZ cord-028721-x6f26ahr 1201 5 probably probably RB cord-028721-x6f26ahr 1201 6 an an DT cord-028721-x6f26ahr 1201 7 androgenic androgenic JJ cord-028721-x6f26ahr 1201 8 event event NN cord-028721-x6f26ahr 1201 9 that that WDT cord-028721-x6f26ahr 1201 10 does do VBZ cord-028721-x6f26ahr 1201 11 not not RB cord-028721-x6f26ahr 1201 12 occur occur VB cord-028721-x6f26ahr 1201 13 in in IN cord-028721-x6f26ahr 1201 14 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1201 15 testes testis NNS cord-028721-x6f26ahr 1201 16 and and CC cord-028721-x6f26ahr 1201 17 agrees agree VBZ cord-028721-x6f26ahr 1201 18 with with IN cord-028721-x6f26ahr 1201 19 the the DT cord-028721-x6f26ahr 1201 20 characteristic characteristic JJ cord-028721-x6f26ahr 1201 21 low low JJ cord-028721-x6f26ahr 1201 22 numbers number NNS cord-028721-x6f26ahr 1201 23 of of IN cord-028721-x6f26ahr 1201 24 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1201 25 in in IN cord-028721-x6f26ahr 1201 26 the the DT cord-028721-x6f26ahr 1201 27 prepubertal prepubertal JJ cord-028721-x6f26ahr 1201 28 age age NN cord-028721-x6f26ahr 1201 29 . . . cord-028721-x6f26ahr 1202 1 523 523 CD cord-028721-x6f26ahr 1202 2 _SP cord-028721-x6f26ahr 1203 1 Prepubertal Prepubertal NNP cord-028721-x6f26ahr 1203 2 testes testis NNS cord-028721-x6f26ahr 1204 1 Undescended undescended JJ cord-028721-x6f26ahr 1204 2 testes testis NNS cord-028721-x6f26ahr 1204 3 are be VBP cord-028721-x6f26ahr 1204 4 usually usually RB cord-028721-x6f26ahr 1204 5 smaller small JJR cord-028721-x6f26ahr 1204 6 than than IN cord-028721-x6f26ahr 1204 7 the the DT cord-028721-x6f26ahr 1204 8 contralateral contralateral JJ cord-028721-x6f26ahr 1204 9 ones one NNS cord-028721-x6f26ahr 1204 10 . . . cord-028721-x6f26ahr 1205 1 This this DT cord-028721-x6f26ahr 1205 2 difference difference NN cord-028721-x6f26ahr 1205 3 is be VBZ cord-028721-x6f26ahr 1205 4 already already RB cord-028721-x6f26ahr 1205 5 significant significant JJ cord-028721-x6f26ahr 1205 6 at at IN cord-028721-x6f26ahr 1205 7 6 6 CD cord-028721-x6f26ahr 1205 8 months month NNS cord-028721-x6f26ahr 1205 9 of of IN cord-028721-x6f26ahr 1205 10 age age NN cord-028721-x6f26ahr 1205 11 . . . cord-028721-x6f26ahr 1206 1 524 524 CD cord-028721-x6f26ahr 1206 2 , , , cord-028721-x6f26ahr 1206 3 525 525 CD cord-028721-x6f26ahr 1207 1 Although although IN cord-028721-x6f26ahr 1207 2 there there EX cord-028721-x6f26ahr 1207 3 have have VBP cord-028721-x6f26ahr 1207 4 been be VBN cord-028721-x6f26ahr 1207 5 a a DT cord-028721-x6f26ahr 1207 6 number number NN cord-028721-x6f26ahr 1207 7 of of IN cord-028721-x6f26ahr 1207 8 biopsy biopsy NN cord-028721-x6f26ahr 1207 9 studies study NNS cord-028721-x6f26ahr 1207 10 in in IN cord-028721-x6f26ahr 1207 11 the the DT cord-028721-x6f26ahr 1207 12 fi fi NN cord-028721-x6f26ahr 1207 13 rst rst FW cord-028721-x6f26ahr 1207 14 years year NNS cord-028721-x6f26ahr 1207 15 of of IN cord-028721-x6f26ahr 1207 16 life life NN cord-028721-x6f26ahr 1207 17 , , , cord-028721-x6f26ahr 1207 18 there there EX cord-028721-x6f26ahr 1207 19 is be VBZ cord-028721-x6f26ahr 1207 20 no no DT cord-028721-x6f26ahr 1207 21 agreement agreement NN cord-028721-x6f26ahr 1207 22 about about IN cord-028721-x6f26ahr 1207 23 the the DT cord-028721-x6f26ahr 1207 24 severity severity NN cord-028721-x6f26ahr 1207 25 of of IN cord-028721-x6f26ahr 1207 26 damage damage NN cord-028721-x6f26ahr 1207 27 or or CC cord-028721-x6f26ahr 1207 28 the the DT cord-028721-x6f26ahr 1207 29 time time NN cord-028721-x6f26ahr 1207 30 of of IN cord-028721-x6f26ahr 1207 31 its -PRON- PRP$ cord-028721-x6f26ahr 1207 32 onset onset NN cord-028721-x6f26ahr 1207 33 . . . cord-028721-x6f26ahr 1208 1 523 523 CD cord-028721-x6f26ahr 1208 2 , , , cord-028721-x6f26ahr 1208 3 526 526 CD cord-028721-x6f26ahr 1208 4 , , , cord-028721-x6f26ahr 1208 5 527 527 CD cord-028721-x6f26ahr 1209 1 Based base VBN cord-028721-x6f26ahr 1209 2 on on IN cord-028721-x6f26ahr 1209 3 the the DT cord-028721-x6f26ahr 1209 4 tubular tubular JJ cord-028721-x6f26ahr 1209 5 fertility fertility NN cord-028721-x6f26ahr 1209 6 index index NN cord-028721-x6f26ahr 1209 7 ( ( -LRB- cord-028721-x6f26ahr 1209 8 TFI TFI NNP cord-028721-x6f26ahr 1209 9 ) ) -RRB- cord-028721-x6f26ahr 1209 10 and and CC cord-028721-x6f26ahr 1209 11 mean mean VB cord-028721-x6f26ahr 1209 12 tubular tubular JJ cord-028721-x6f26ahr 1209 13 diameter diameter NN cord-028721-x6f26ahr 1209 14 ( ( -LRB- cord-028721-x6f26ahr 1209 15 MTD MTD NNP cord-028721-x6f26ahr 1209 16 ) ) -RRB- cord-028721-x6f26ahr 1209 17 , , , cord-028721-x6f26ahr 1209 18 most most JJS cord-028721-x6f26ahr 1209 19 testicular testicular JJ cord-028721-x6f26ahr 1209 20 biopsies biopsy NNS cord-028721-x6f26ahr 1209 21 from from IN cord-028721-x6f26ahr 1209 22 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1209 23 testes testis NNS cord-028721-x6f26ahr 1209 24 of of IN cord-028721-x6f26ahr 1209 25 children child NNS cord-028721-x6f26ahr 1209 26 can can MD cord-028721-x6f26ahr 1209 27 be be VB cord-028721-x6f26ahr 1209 28 classifi classifi NNP cord-028721-x6f26ahr 1209 29 ed ed NN cord-028721-x6f26ahr 1209 30 into into IN cord-028721-x6f26ahr 1209 31 one one CD cord-028721-x6f26ahr 1209 32 of of IN cord-028721-x6f26ahr 1209 33 three three CD cord-028721-x6f26ahr 1209 34 groups group NNS cord-028721-x6f26ahr 1209 35 : : : cord-028721-x6f26ahr 1210 1 • • NNP cord-028721-x6f26ahr 1211 1 Type type NN cord-028721-x6f26ahr 1211 2 I -PRON- PRP cord-028721-x6f26ahr 1211 3 ( ( -LRB- cord-028721-x6f26ahr 1211 4 testes testis NNS cord-028721-x6f26ahr 1211 5 with with IN cord-028721-x6f26ahr 1211 6 slight slight JJ cord-028721-x6f26ahr 1211 7 alterations alteration NNS cord-028721-x6f26ahr 1211 8 ) ) -RRB- cord-028721-x6f26ahr 1211 9 . . . cord-028721-x6f26ahr 1212 1 The the DT cord-028721-x6f26ahr 1212 2 tubular tubular JJ cord-028721-x6f26ahr 1212 3 fertility fertility NN cord-028721-x6f26ahr 1212 4 index index NN cord-028721-x6f26ahr 1212 5 is be VBZ cord-028721-x6f26ahr 1212 6 higher high JJR cord-028721-x6f26ahr 1212 7 than than IN cord-028721-x6f26ahr 1212 8 50 50 CD cord-028721-x6f26ahr 1212 9 , , , cord-028721-x6f26ahr 1212 10 and and CC cord-028721-x6f26ahr 1212 11 the the DT cord-028721-x6f26ahr 1212 12 mean mean JJ cord-028721-x6f26ahr 1212 13 tubular tubular JJ cord-028721-x6f26ahr 1212 14 diameter diameter NN cord-028721-x6f26ahr 1212 15 is be VBZ cord-028721-x6f26ahr 1212 16 normal normal JJ cord-028721-x6f26ahr 1212 17 or or CC cord-028721-x6f26ahr 1212 18 slightly slightly RB cord-028721-x6f26ahr 1212 19 ( ( -LRB- cord-028721-x6f26ahr 1212 20 < < XX cord-028721-x6f26ahr 1212 21 10 10 CD cord-028721-x6f26ahr 1212 22 % % NN cord-028721-x6f26ahr 1212 23 ) ) -RRB- cord-028721-x6f26ahr 1212 24 decreased decrease VBD cord-028721-x6f26ahr 1212 25 . . . cord-028721-x6f26ahr 1213 1 Approximately approximately RB cord-028721-x6f26ahr 1213 2 31 31 CD cord-028721-x6f26ahr 1213 3 % % NN cord-028721-x6f26ahr 1213 4 of of IN cord-028721-x6f26ahr 1213 5 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1213 6 testes testis NNS cord-028721-x6f26ahr 1213 7 are be VBP cord-028721-x6f26ahr 1213 8 in in IN cord-028721-x6f26ahr 1213 9 this this DT cord-028721-x6f26ahr 1213 10 group group NN cord-028721-x6f26ahr 1213 11 ( ( -LRB- cord-028721-x6f26ahr 1213 12 Fig Fig NNP cord-028721-x6f26ahr 1213 13 . . . cord-028721-x6f26ahr 1213 14 12 12 CD cord-028721-x6f26ahr 1213 15 - - SYM cord-028721-x6f26ahr 1213 16 49 49 CD cord-028721-x6f26ahr 1213 17 ) ) -RRB- cord-028721-x6f26ahr 1213 18 . . . cord-028721-x6f26ahr 1214 1 • • NNP cord-028721-x6f26ahr 1214 2 Type Type NNP cord-028721-x6f26ahr 1214 3 II II NNP cord-028721-x6f26ahr 1214 4 ( ( -LRB- cord-028721-x6f26ahr 1214 5 testes testis NNS cord-028721-x6f26ahr 1214 6 with with IN cord-028721-x6f26ahr 1214 7 marked marked JJ cord-028721-x6f26ahr 1214 8 germinal germinal JJ cord-028721-x6f26ahr 1214 9 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1214 10 ) ) -RRB- cord-028721-x6f26ahr 1214 11 . . . cord-028721-x6f26ahr 1215 1 Tubular tubular JJ cord-028721-x6f26ahr 1215 2 fertility fertility NN cord-028721-x6f26ahr 1215 3 index index NN cord-028721-x6f26ahr 1215 4 is be VBZ cord-028721-x6f26ahr 1215 5 between between IN cord-028721-x6f26ahr 1215 6 30 30 CD cord-028721-x6f26ahr 1215 7 and and CC cord-028721-x6f26ahr 1215 8 50 50 CD cord-028721-x6f26ahr 1215 9 , , , cord-028721-x6f26ahr 1215 10 and and CC cord-028721-x6f26ahr 1215 11 mean mean VB cord-028721-x6f26ahr 1215 12 tubular tubular JJ cord-028721-x6f26ahr 1215 13 diameter diameter NN cord-028721-x6f26ahr 1215 14 is be VBZ cord-028721-x6f26ahr 1215 15 10 10 CD cord-028721-x6f26ahr 1215 16 - - SYM cord-028721-x6f26ahr 1215 17 30 30 CD cord-028721-x6f26ahr 1215 18 % % NN cord-028721-x6f26ahr 1215 19 lower low JJR cord-028721-x6f26ahr 1215 20 than than IN cord-028721-x6f26ahr 1215 21 normal normal JJ cord-028721-x6f26ahr 1215 22 . . . cord-028721-x6f26ahr 1216 1 The the DT cord-028721-x6f26ahr 1216 2 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1216 3 are be VBP cord-028721-x6f26ahr 1216 4 distributed distribute VBN cord-028721-x6f26ahr 1216 5 irregularly irregularly RB cord-028721-x6f26ahr 1216 6 and and CC cord-028721-x6f26ahr 1216 7 most most JJS cord-028721-x6f26ahr 1216 8 are be VBP cord-028721-x6f26ahr 1216 9 in in IN cord-028721-x6f26ahr 1216 10 tubular tubular JJ cord-028721-x6f26ahr 1216 11 sections section NNS cord-028721-x6f26ahr 1216 12 that that WDT cord-028721-x6f26ahr 1216 13 are be VBP cord-028721-x6f26ahr 1216 14 grouped group VBN cord-028721-x6f26ahr 1216 15 in in IN cord-028721-x6f26ahr 1216 16 the the DT cord-028721-x6f26ahr 1216 17 same same JJ cord-028721-x6f26ahr 1216 18 testicular testicular NN cord-028721-x6f26ahr 1216 19 lobule lobule NN cord-028721-x6f26ahr 1216 20 . . . cord-028721-x6f26ahr 1217 1 These these DT cord-028721-x6f26ahr 1217 2 testes testis NNS cord-028721-x6f26ahr 1217 3 comprise comprise VBP cord-028721-x6f26ahr 1217 4 approximately approximately RB cord-028721-x6f26ahr 1217 5 29 29 CD cord-028721-x6f26ahr 1217 6 % % NN cord-028721-x6f26ahr 1217 7 of of IN cord-028721-x6f26ahr 1217 8 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1217 9 testes testis NNS cord-028721-x6f26ahr 1217 10 ( ( -LRB- cord-028721-x6f26ahr 1217 11 Fig Fig NNP cord-028721-x6f26ahr 1217 12 . . . cord-028721-x6f26ahr 1217 13 12 12 CD cord-028721-x6f26ahr 1217 14 - - SYM cord-028721-x6f26ahr 1217 15 50 50 CD cord-028721-x6f26ahr 1217 16 ) ) -RRB- cord-028721-x6f26ahr 1217 17 . . . cord-028721-x6f26ahr 1218 1 528 528 CD cord-028721-x6f26ahr 1218 2 • • NN cord-028721-x6f26ahr 1218 3 Type type NN cord-028721-x6f26ahr 1218 4 III III NNP cord-028721-x6f26ahr 1218 5 ( ( -LRB- cord-028721-x6f26ahr 1218 6 testes testis NNS cord-028721-x6f26ahr 1218 7 with with IN cord-028721-x6f26ahr 1218 8 severe severe JJ cord-028721-x6f26ahr 1218 9 germinal germinal JJ cord-028721-x6f26ahr 1218 10 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1218 11 ) ) -RRB- cord-028721-x6f26ahr 1218 12 . . . cord-028721-x6f26ahr 1219 1 Tubular tubular JJ cord-028721-x6f26ahr 1219 2 fertility fertility NN cord-028721-x6f26ahr 1219 3 index index NN cord-028721-x6f26ahr 1219 4 is be VBZ cord-028721-x6f26ahr 1219 5 less less JJR cord-028721-x6f26ahr 1219 6 than than IN cord-028721-x6f26ahr 1219 7 30 30 CD cord-028721-x6f26ahr 1219 8 , , , cord-028721-x6f26ahr 1219 9 and and CC cord-028721-x6f26ahr 1219 10 mean mean VB cord-028721-x6f26ahr 1219 11 tubular tubular JJ cord-028721-x6f26ahr 1219 12 diameter diameter NN cord-028721-x6f26ahr 1219 13 less less JJR cord-028721-x6f26ahr 1219 14 than than IN cord-028721-x6f26ahr 1219 15 30 30 CD cord-028721-x6f26ahr 1219 16 % % NN cord-028721-x6f26ahr 1219 17 of of IN cord-028721-x6f26ahr 1219 18 normal normal JJ cord-028721-x6f26ahr 1219 19 . . . cord-028721-x6f26ahr 1220 1 Many many JJ cord-028721-x6f26ahr 1220 2 of of IN cord-028721-x6f26ahr 1220 3 the the DT cord-028721-x6f26ahr 1220 4 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1220 5 are be VBP cord-028721-x6f26ahr 1220 6 giant giant JJ cord-028721-x6f26ahr 1220 7 with with IN cord-028721-x6f26ahr 1220 8 dark dark JJ cord-028721-x6f26ahr 1220 9 nuclei nucleus NNS cord-028721-x6f26ahr 1221 1 ( ( -LRB- cord-028721-x6f26ahr 1221 2 Fig Fig NNP cord-028721-x6f26ahr 1221 3 . . . cord-028721-x6f26ahr 1222 1 12 12 CD cord-028721-x6f26ahr 1222 2 -51 -51 NN cord-028721-x6f26ahr 1222 3 ) ) -RRB- cord-028721-x6f26ahr 1222 4 . . . cord-028721-x6f26ahr 1223 1 These these DT cord-028721-x6f26ahr 1223 2 testes testis NNS cord-028721-x6f26ahr 1223 3 often often RB cord-028721-x6f26ahr 1223 4 contain contain VBP cord-028721-x6f26ahr 1223 5 ring ring NN cord-028721-x6f26ahr 1223 6 - - HYPH cord-028721-x6f26ahr 1223 7 shaped shape VBN cord-028721-x6f26ahr 1223 8 tubules tubule NNS cord-028721-x6f26ahr 1223 9 , , , cord-028721-x6f26ahr 1223 10 induced induce VBN cord-028721-x6f26ahr 1223 11 by by IN cord-028721-x6f26ahr 1223 12 increased increase VBN cord-028721-x6f26ahr 1223 13 temperature temperature NN cord-028721-x6f26ahr 1223 14 . . . cord-028721-x6f26ahr 1224 1 527 527 CD cord-028721-x6f26ahr 1224 2 Testes testis NNS cord-028721-x6f26ahr 1224 3 with with IN cord-028721-x6f26ahr 1224 4 type type NN cord-028721-x6f26ahr 1224 5 II II NNP cord-028721-x6f26ahr 1224 6 or or CC cord-028721-x6f26ahr 1224 7 III iii CD cord-028721-x6f26ahr 1224 8 lesions lesion NNS cord-028721-x6f26ahr 1224 9 bear bear VBP cord-028721-x6f26ahr 1224 10 variable variable NN cord-028721-x6f26ahr 1224 11 degrees degree NNS cord-028721-x6f26ahr 1224 12 of of IN cord-028721-x6f26ahr 1224 13 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1224 14 that that IN cord-028721-x6f26ahr 1224 15 , , , cord-028721-x6f26ahr 1224 16 in in IN cord-028721-x6f26ahr 1224 17 addition addition NN cord-028721-x6f26ahr 1224 18 to to IN cord-028721-x6f26ahr 1224 19 germ germ NN cord-028721-x6f26ahr 1224 20 cells cell NNS cord-028721-x6f26ahr 1224 21 , , , cord-028721-x6f26ahr 1224 22 involve involve VBP cord-028721-x6f26ahr 1224 23 Sertoli Sertoli NNP cord-028721-x6f26ahr 1224 24 cells cell NNS cord-028721-x6f26ahr 1224 25 , , , cord-028721-x6f26ahr 1224 26 peritubular peritubular NNP cord-028721-x6f26ahr 1224 27 myofibroblasts myofibroblasts NNP cord-028721-x6f26ahr 1224 28 , , , cord-028721-x6f26ahr 1224 29 and and CC cord-028721-x6f26ahr 1224 30 Leydig Leydig NNP cord-028721-x6f26ahr 1224 31 cells cell NNS cord-028721-x6f26ahr 1224 32 . . . cord-028721-x6f26ahr 1225 1 The the DT cord-028721-x6f26ahr 1225 2 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1225 3 of of IN cord-028721-x6f26ahr 1225 4 these these DT cord-028721-x6f26ahr 1225 5 other other JJ cord-028721-x6f26ahr 1225 6 cell cell NN cord-028721-x6f26ahr 1225 7 types type NNS cord-028721-x6f26ahr 1225 8 is be VBZ cord-028721-x6f26ahr 1225 9 evident evident JJ cord-028721-x6f26ahr 1225 10 only only RB cord-028721-x6f26ahr 1225 11 after after IN cord-028721-x6f26ahr 1225 12 puberty puberty NN cord-028721-x6f26ahr 1225 13 . . . cord-028721-x6f26ahr 1226 1 In in IN cord-028721-x6f26ahr 1226 2 about about RB cord-028721-x6f26ahr 1226 3 25 25 CD cord-028721-x6f26ahr 1226 4 % % NN cord-028721-x6f26ahr 1226 5 of of IN cord-028721-x6f26ahr 1226 6 cases case NNS cord-028721-x6f26ahr 1226 7 the the DT cord-028721-x6f26ahr 1226 8 contralateral contralateral JJ cord-028721-x6f26ahr 1226 9 scrotal scrotal JJ cord-028721-x6f26ahr 1226 10 testis testis NN cord-028721-x6f26ahr 1226 11 also also RB cord-028721-x6f26ahr 1226 12 has have VBZ cord-028721-x6f26ahr 1226 13 histologic histologic JJ cord-028721-x6f26ahr 1226 14 lesions lesion NNS cord-028721-x6f26ahr 1226 15 of of IN cord-028721-x6f26ahr 1226 16 variable variable JJ cord-028721-x6f26ahr 1226 17 severity severity NN cord-028721-x6f26ahr 1226 18 . . . cord-028721-x6f26ahr 1227 1 This this DT cord-028721-x6f26ahr 1227 2 fi fi NN cord-028721-x6f26ahr 1227 3 nding nding NN cord-028721-x6f26ahr 1227 4 supports support VBZ cord-028721-x6f26ahr 1227 5 the the DT cord-028721-x6f26ahr 1227 6 hypothesis hypothesis NN cord-028721-x6f26ahr 1227 7 of of IN cord-028721-x6f26ahr 1227 8 a a DT cord-028721-x6f26ahr 1227 9 bilateral bilateral JJ cord-028721-x6f26ahr 1227 10 defect defect NN cord-028721-x6f26ahr 1227 11 in in IN cord-028721-x6f26ahr 1227 12 many many JJ cord-028721-x6f26ahr 1227 13 cases case NNS cord-028721-x6f26ahr 1227 14 of of IN cord-028721-x6f26ahr 1227 15 unilateral unilateral JJ cord-028721-x6f26ahr 1227 16 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1227 17 . . . cord-028721-x6f26ahr 1228 1 Microdeletions microdeletion NNS cord-028721-x6f26ahr 1228 2 in in IN cord-028721-x6f26ahr 1228 3 the the DT cord-028721-x6f26ahr 1228 4 long long JJ cord-028721-x6f26ahr 1228 5 arm arm NN cord-028721-x6f26ahr 1228 6 of of IN cord-028721-x6f26ahr 1228 7 the the DT cord-028721-x6f26ahr 1228 8 Y Y NNP cord-028721-x6f26ahr 1228 9 chromosome chromosome NN cord-028721-x6f26ahr 1228 10 are be VBP cord-028721-x6f26ahr 1228 11 present present JJ cord-028721-x6f26ahr 1228 12 in in IN cord-028721-x6f26ahr 1228 13 27 27 CD cord-028721-x6f26ahr 1228 14 % % NN cord-028721-x6f26ahr 1228 15 of of IN cord-028721-x6f26ahr 1228 16 patients patient NNS cord-028721-x6f26ahr 1228 17 with with IN cord-028721-x6f26ahr 1228 18 corrected correct VBN cord-028721-x6f26ahr 1228 19 unilateral unilateral JJ cord-028721-x6f26ahr 1228 20 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1228 21 who who WP cord-028721-x6f26ahr 1228 22 present present VBP cord-028721-x6f26ahr 1228 23 with with IN cord-028721-x6f26ahr 1228 24 azoospermia azoospermia NN cord-028721-x6f26ahr 1228 25 or or CC cord-028721-x6f26ahr 1228 26 severe severe JJ cord-028721-x6f26ahr 1228 27 oligospermia oligospermia NN cord-028721-x6f26ahr 1228 28 . . . cord-028721-x6f26ahr 1229 1 530 530 CD cord-028721-x6f26ahr 1230 1 These these DT cord-028721-x6f26ahr 1230 2 fi fi NNP cord-028721-x6f26ahr 1230 3 ndings nding NNS cord-028721-x6f26ahr 1230 4 are be VBP cord-028721-x6f26ahr 1230 5 similar similar JJ cord-028721-x6f26ahr 1230 6 to to IN cord-028721-x6f26ahr 1230 7 those those DT cord-028721-x6f26ahr 1230 8 observed observe VBN cord-028721-x6f26ahr 1230 9 in in IN cord-028721-x6f26ahr 1230 10 patients patient NNS cord-028721-x6f26ahr 1230 11 with with IN cord-028721-x6f26ahr 1230 12 azoospermia azoospermia NN cord-028721-x6f26ahr 1230 13 or or CC cord-028721-x6f26ahr 1230 14 severe severe JJ cord-028721-x6f26ahr 1230 15 idiopathic idiopathic JJ cord-028721-x6f26ahr 1230 16 oligospermia oligospermia NN cord-028721-x6f26ahr 1230 17 . . . cord-028721-x6f26ahr 1231 1 Unilateral unilateral JJ cord-028721-x6f26ahr 1231 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1231 3 with with IN cord-028721-x6f26ahr 1231 4 a a DT cord-028721-x6f26ahr 1231 5 normal normal JJ cord-028721-x6f26ahr 1231 6 contralateral contralateral JJ cord-028721-x6f26ahr 1231 7 testis testis NN cord-028721-x6f26ahr 1231 8 could could MD cord-028721-x6f26ahr 1231 9 be be VB cord-028721-x6f26ahr 1231 10 due due JJ cord-028721-x6f26ahr 1231 11 to to IN cord-028721-x6f26ahr 1231 12 an an DT cord-028721-x6f26ahr 1231 13 end end NN cord-028721-x6f26ahr 1231 14 - - HYPH cord-028721-x6f26ahr 1231 15 organ organ NN cord-028721-x6f26ahr 1231 16 failure failure NN cord-028721-x6f26ahr 1231 17 . . . cord-028721-x6f26ahr 1232 1 531 531 CD cord-028721-x6f26ahr 1233 1 In in IN cord-028721-x6f26ahr 1233 2 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1233 3 secondary secondary JJ cord-028721-x6f26ahr 1233 4 to to IN cord-028721-x6f26ahr 1233 5 spontaneous spontaneous JJ cord-028721-x6f26ahr 1233 6 ascent ascent NN cord-028721-x6f26ahr 1233 7 , , , cord-028721-x6f26ahr 1233 8 lesions lesion NNS cord-028721-x6f26ahr 1233 9 are be VBP cord-028721-x6f26ahr 1233 10 similar similar JJ cord-028721-x6f26ahr 1233 11 to to IN cord-028721-x6f26ahr 1233 12 megatubules megatubules NNP cord-028721-x6f26ahr 1233 13 ( ( -LRB- cord-028721-x6f26ahr 1233 14 with with IN cord-028721-x6f26ahr 1233 15 or or CC cord-028721-x6f26ahr 1233 16 without without IN cord-028721-x6f26ahr 1233 17 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 1233 18 bodies body NNS cord-028721-x6f26ahr 1233 19 or or CC cord-028721-x6f26ahr 1233 20 microliths microlith NNS cord-028721-x6f26ahr 1233 21 ) ) -RRB- cord-028721-x6f26ahr 1233 22 ( ( -LRB- cord-028721-x6f26ahr 1233 23 Fig fig NN cord-028721-x6f26ahr 1233 24 . . . cord-028721-x6f26ahr 1234 1 12 12 CD cord-028721-x6f26ahr 1234 2 - - SYM cord-028721-x6f26ahr 1234 3 52 52 CD cord-028721-x6f26ahr 1234 4 ) ) -RRB- cord-028721-x6f26ahr 1234 5 , , , cord-028721-x6f26ahr 1234 6 and and CC cord-028721-x6f26ahr 1234 7 focal focal JJ cord-028721-x6f26ahr 1234 8 granular granular JJ cord-028721-x6f26ahr 1234 9 changes change NNS cord-028721-x6f26ahr 1234 10 in in IN cord-028721-x6f26ahr 1234 11 the the DT cord-028721-x6f26ahr 1234 12 Sertoli Sertoli NNP cord-028721-x6f26ahr 1234 13 cells cell NNS cord-028721-x6f26ahr 1234 14 ( ( -LRB- cord-028721-x6f26ahr 1234 15 Fig Fig NNP cord-028721-x6f26ahr 1234 16 . . . cord-028721-x6f26ahr 1234 17 12 12 CD cord-028721-x6f26ahr 1234 18 - - SYM cord-028721-x6f26ahr 1234 19 53 53 CD cord-028721-x6f26ahr 1234 20 ) ) -RRB- cord-028721-x6f26ahr 1234 21 . . . cord-028721-x6f26ahr 1235 1 The the DT cord-028721-x6f26ahr 1235 2 testicular testicular JJ cord-028721-x6f26ahr 1235 3 interstitium interstitium NN cord-028721-x6f26ahr 1235 4 is be VBZ cord-028721-x6f26ahr 1235 5 wide wide JJ cord-028721-x6f26ahr 1235 6 and and CC cord-028721-x6f26ahr 1235 7 edematous edematous JJ cord-028721-x6f26ahr 1235 8 . . . cord-028721-x6f26ahr 1236 1 These these DT cord-028721-x6f26ahr 1236 2 comprise comprise VBP cord-028721-x6f26ahr 1236 3 about about RB cord-028721-x6f26ahr 1236 4 40 40 CD cord-028721-x6f26ahr 1236 5 % % NN cord-028721-x6f26ahr 1236 6 of of IN cord-028721-x6f26ahr 1236 7 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1236 8 testes testis NNS cord-028721-x6f26ahr 1236 9 . . . cord-028721-x6f26ahr 1237 1 About about IN cord-028721-x6f26ahr 1237 2 8 8 CD cord-028721-x6f26ahr 1237 3 % % NN cord-028721-x6f26ahr 1237 4 of of IN cord-028721-x6f26ahr 1237 5 tests test NNS cord-028721-x6f26ahr 1237 6 with with IN cord-028721-x6f26ahr 1237 7 type type NN cord-028721-x6f26ahr 1237 8 I -PRON- PRP cord-028721-x6f26ahr 1237 9 lesions lesion NNS cord-028721-x6f26ahr 1237 10 show show VBP cord-028721-x6f26ahr 1237 11 many many JJ cord-028721-x6f26ahr 1237 12 multinucleated multinucleate VBN cord-028721-x6f26ahr 1237 13 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1237 14 ( ( -LRB- cord-028721-x6f26ahr 1237 15 with with IN cord-028721-x6f26ahr 1237 16 three three CD cord-028721-x6f26ahr 1237 17 or or CC cord-028721-x6f26ahr 1237 18 more more JJR cord-028721-x6f26ahr 1237 19 nuclei nucleus NNS cord-028721-x6f26ahr 1237 20 ) ) -RRB- cord-028721-x6f26ahr 1238 1 ( ( -LRB- cord-028721-x6f26ahr 1238 2 Fig Fig NNP cord-028721-x6f26ahr 1238 3 . . . cord-028721-x6f26ahr 1238 4 12 12 CD cord-028721-x6f26ahr 1238 5 - - SYM cord-028721-x6f26ahr 1238 6 54 54 CD cord-028721-x6f26ahr 1238 7 ) ) -RRB- cord-028721-x6f26ahr 1238 8 . . . cord-028721-x6f26ahr 1239 1 529 529 CD cord-028721-x6f26ahr 1240 1 The the DT cord-028721-x6f26ahr 1240 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1240 3 tubules tubule NNS cord-028721-x6f26ahr 1240 4 of of IN cord-028721-x6f26ahr 1240 5 testes testis NNS cord-028721-x6f26ahr 1240 6 with with IN cord-028721-x6f26ahr 1240 7 types type NNS cord-028721-x6f26ahr 1240 8 II II NNP cord-028721-x6f26ahr 1240 9 or or CC cord-028721-x6f26ahr 1240 10 III iii CD cord-028721-x6f26ahr 1240 11 lesions lesion NNS cord-028721-x6f26ahr 1240 12 have have VBP cord-028721-x6f26ahr 1240 13 a a DT cord-028721-x6f26ahr 1240 14 thickened thicken VBN cord-028721-x6f26ahr 1240 15 lamina lamina NN cord-028721-x6f26ahr 1240 16 propria propria NN cord-028721-x6f26ahr 1240 17 during during IN cord-028721-x6f26ahr 1240 18 childhood childhood NN cord-028721-x6f26ahr 1240 19 and and CC cord-028721-x6f26ahr 1240 20 , , , cord-028721-x6f26ahr 1241 1 at at IN cord-028721-x6f26ahr 1241 2 puberty puberty NN cord-028721-x6f26ahr 1241 3 , , , cord-028721-x6f26ahr 1241 4 Sertoli sertoli JJ cord-028721-x6f26ahr 1241 5 cell cell NN cord-028721-x6f26ahr 1241 6 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1241 7 . . . cord-028721-x6f26ahr 1242 1 526 526 CD cord-028721-x6f26ahr 1242 2 Patients patient NNS cord-028721-x6f26ahr 1242 3 with with IN cord-028721-x6f26ahr 1242 4 bilateral bilateral JJ cord-028721-x6f26ahr 1242 5 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1242 6 have have VBP cord-028721-x6f26ahr 1242 7 a a DT cord-028721-x6f26ahr 1242 8 higher high JJR cord-028721-x6f26ahr 1242 9 incidence incidence NN cord-028721-x6f26ahr 1242 10 of of IN cord-028721-x6f26ahr 1242 11 type type NN cord-028721-x6f26ahr 1242 12 II II NNP cord-028721-x6f26ahr 1242 13 and and CC cord-028721-x6f26ahr 1242 14 III iii CD cord-028721-x6f26ahr 1242 15 lesions lesion NNS cord-028721-x6f26ahr 1242 16 than than IN cord-028721-x6f26ahr 1242 17 those those DT cord-028721-x6f26ahr 1242 18 with with IN cord-028721-x6f26ahr 1242 19 unilateral unilateral JJ cord-028721-x6f26ahr 1242 20 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1242 21 . . . cord-028721-x6f26ahr 1243 1 Type type NN cord-028721-x6f26ahr 1243 2 I -PRON- PRP cord-028721-x6f26ahr 1243 3 lesions lesion NNS cord-028721-x6f26ahr 1243 4 are be VBP cord-028721-x6f26ahr 1243 5 comparable comparable JJ cord-028721-x6f26ahr 1243 6 to to IN cord-028721-x6f26ahr 1243 7 those those DT cord-028721-x6f26ahr 1243 8 seen see VBN cord-028721-x6f26ahr 1243 9 in in IN cord-028721-x6f26ahr 1243 10 experimental experimental JJ cord-028721-x6f26ahr 1243 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1243 12 ; ; : cord-028721-x6f26ahr 1243 13 normal normal JJ cord-028721-x6f26ahr 1243 14 testes testis NNS cord-028721-x6f26ahr 1243 15 in in IN cord-028721-x6f26ahr 1243 16 which which WDT cord-028721-x6f26ahr 1243 17 lesions lesion NNS cord-028721-x6f26ahr 1243 18 were be VBD cord-028721-x6f26ahr 1243 19 those those DT cord-028721-x6f26ahr 1243 20 of of IN cord-028721-x6f26ahr 1243 21 congenital congenital JJ cord-028721-x6f26ahr 1243 22 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1243 23 , , , cord-028721-x6f26ahr 1243 24 whereas whereas IN cord-028721-x6f26ahr 1243 25 in in IN cord-028721-x6f26ahr 1243 26 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1243 27 secondary secondary JJ cord-028721-x6f26ahr 1243 28 to to IN cord-028721-x6f26ahr 1243 29 herniotomy herniotomy NN cord-028721-x6f26ahr 1243 30 , , , cord-028721-x6f26ahr 1243 31 germ germ NN cord-028721-x6f26ahr 1243 32 cell cell NN cord-028721-x6f26ahr 1243 33 depletion depletion NN cord-028721-x6f26ahr 1243 34 is be VBZ cord-028721-x6f26ahr 1243 35 slight slight JJ cord-028721-x6f26ahr 1243 36 532 532 CD cord-028721-x6f26ahr 1243 37 and and CC cord-028721-x6f26ahr 1243 38 becomes become VBZ cord-028721-x6f26ahr 1243 39 important important JJ cord-028721-x6f26ahr 1243 40 only only RB cord-028721-x6f26ahr 1243 41 after after IN cord-028721-x6f26ahr 1243 42 5 5 CD cord-028721-x6f26ahr 1243 43 years year NNS cord-028721-x6f26ahr 1243 44 of of IN cord-028721-x6f26ahr 1243 45 age age NN cord-028721-x6f26ahr 1243 46 . . . cord-028721-x6f26ahr 1244 1 533 533 CD cord-028721-x6f26ahr 1244 2 Adult adult NN cord-028721-x6f26ahr 1244 3 testes testis NNS cord-028721-x6f26ahr 1244 4 Most most RBS cord-028721-x6f26ahr 1244 5 pubertal pubertal JJ cord-028721-x6f26ahr 1244 6 and and CC cord-028721-x6f26ahr 1244 7 adult adult JJ cord-028721-x6f26ahr 1244 8 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1244 9 testes testis NNS cord-028721-x6f26ahr 1244 10 have have VBP cord-028721-x6f26ahr 1244 11 anomalies anomaly NNS cord-028721-x6f26ahr 1244 12 in in IN cord-028721-x6f26ahr 1244 13 all all DT cord-028721-x6f26ahr 1244 14 testicular testicular JJ cord-028721-x6f26ahr 1244 15 structures structure NNS cord-028721-x6f26ahr 1244 16 . . . cord-028721-x6f26ahr 1245 1 The the DT cord-028721-x6f26ahr 1245 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1245 3 tubules tubule NNS cord-028721-x6f26ahr 1245 4 have have VBP cord-028721-x6f26ahr 1245 5 decreased decrease VBN cord-028721-x6f26ahr 1245 6 diameters diameter NNS cord-028721-x6f26ahr 1245 7 and and CC cord-028721-x6f26ahr 1245 8 defi defi NNP cord-028721-x6f26ahr 1245 9 cient cient NNP cord-028721-x6f26ahr 1245 10 spermatogenesis spermatogenesis NNP cord-028721-x6f26ahr 1245 11 . . . cord-028721-x6f26ahr 1246 1 In in IN cord-028721-x6f26ahr 1246 2 decreasing decrease VBG cord-028721-x6f26ahr 1246 3 order order NN cord-028721-x6f26ahr 1246 4 of of IN cord-028721-x6f26ahr 1246 5 frequency frequency NN cord-028721-x6f26ahr 1246 6 , , , cord-028721-x6f26ahr 1246 7 the the DT cord-028721-x6f26ahr 1246 8 most most RBS cord-028721-x6f26ahr 1246 9 common common JJ cord-028721-x6f26ahr 1246 10 germ germ NN cord-028721-x6f26ahr 1246 11 cell cell NN cord-028721-x6f26ahr 1246 12 lesions lesion NNS cord-028721-x6f26ahr 1246 13 are be VBP cord-028721-x6f26ahr 1246 14 tubules tubule NNS cord-028721-x6f26ahr 1246 15 with with IN cord-028721-x6f26ahr 1246 16 Sertoli sertoli JJ cord-028721-x6f26ahr 1246 17 cell cell NN cord-028721-x6f26ahr 1246 18 and and CC cord-028721-x6f26ahr 1246 19 spermatogonia spermatogonia NN cord-028721-x6f26ahr 1246 20 - - HYPH cord-028721-x6f26ahr 1246 21 only only JJ cord-028721-x6f26ahr 1246 22 pattern pattern NN cord-028721-x6f26ahr 1246 23 ; ; : cord-028721-x6f26ahr 1246 24 tubules tubule NNS cord-028721-x6f26ahr 1246 25 with with IN cord-028721-x6f26ahr 1246 26 Sertoli Sertoli NNP cord-028721-x6f26ahr 1246 27 cells cell NNS cord-028721-x6f26ahr 1246 28 ( ( -LRB- cord-028721-x6f26ahr 1246 29 dysgenetic dysgenetic NNP cord-028721-x6f26ahr 1246 30 ) ) -RRB- cord-028721-x6f26ahr 1246 31 only only RB cord-028721-x6f26ahr 1246 32 ; ; : cord-028721-x6f26ahr 1246 33 tubular tubular JJ cord-028721-x6f26ahr 1246 34 hyalinization hyalinization NN cord-028721-x6f26ahr 1246 35 ; ; : cord-028721-x6f26ahr 1246 36 and and CC cord-028721-x6f26ahr 1246 37 mixed mixed JJ cord-028721-x6f26ahr 1246 38 atrophy atrophy NN cord-028721-x6f26ahr 1246 39 . . . cord-028721-x6f26ahr 1247 1 The the DT cord-028721-x6f26ahr 1247 2 lamina lamina JJ cord-028721-x6f26ahr 1247 3 propria propria NN cord-028721-x6f26ahr 1247 4 has have VBZ cord-028721-x6f26ahr 1247 5 scant scant JJ cord-028721-x6f26ahr 1247 6 elastic elastic JJ cord-028721-x6f26ahr 1247 7 fi fi NN cord-028721-x6f26ahr 1247 8 bers ber NNS cord-028721-x6f26ahr 1247 9 and and CC cord-028721-x6f26ahr 1247 10 increased increase VBN cord-028721-x6f26ahr 1247 11 collagen collagen NN cord-028721-x6f26ahr 1247 12 fi fi NN cord-028721-x6f26ahr 1247 13 bers ber NNS cord-028721-x6f26ahr 1247 14 . . . cord-028721-x6f26ahr 1248 1 534 534 CD cord-028721-x6f26ahr 1249 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1249 2 cells cell NNS cord-028721-x6f26ahr 1249 3 are be VBP cord-028721-x6f26ahr 1249 4 present present JJ cord-028721-x6f26ahr 1249 5 in in IN cord-028721-x6f26ahr 1249 6 increased increase VBN cord-028721-x6f26ahr 1249 7 numbers number NNS cord-028721-x6f26ahr 1249 8 and and CC cord-028721-x6f26ahr 1249 9 do do VBP cord-028721-x6f26ahr 1249 10 not not RB cord-028721-x6f26ahr 1249 11 mature mature VB cord-028721-x6f26ahr 1249 12 normally normally RB cord-028721-x6f26ahr 1249 13 except except IN cord-028721-x6f26ahr 1249 14 in in IN cord-028721-x6f26ahr 1249 15 tubules tubule NNS cord-028721-x6f26ahr 1249 16 with with IN cord-028721-x6f26ahr 1249 17 germ germ NN cord-028721-x6f26ahr 1249 18 cells cell NNS cord-028721-x6f26ahr 1249 19 ( ( -LRB- cord-028721-x6f26ahr 1249 20 Fig Fig NNP cord-028721-x6f26ahr 1249 21 . . . cord-028721-x6f26ahr 1249 22 12 12 CD cord-028721-x6f26ahr 1249 23 - - SYM cord-028721-x6f26ahr 1249 24 55 55 CD cord-028721-x6f26ahr 1249 25 ) ) -RRB- cord-028721-x6f26ahr 1249 26 . . . cord-028721-x6f26ahr 1250 1 528 528 CD cord-028721-x6f26ahr 1250 2 , , , cord-028721-x6f26ahr 1250 3 535 535 CD cord-028721-x6f26ahr 1251 1 Often often RB cord-028721-x6f26ahr 1251 2 , , , cord-028721-x6f26ahr 1251 3 groups group NNS cord-028721-x6f26ahr 1251 4 of of IN cord-028721-x6f26ahr 1251 5 tubules tubule NNS cord-028721-x6f26ahr 1251 6 containing contain VBG cord-028721-x6f26ahr 1251 7 only only RB cord-028721-x6f26ahr 1251 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 1251 9 cells cell NNS cord-028721-x6f26ahr 1251 10 with with IN cord-028721-x6f26ahr 1251 11 a a DT cord-028721-x6f26ahr 1251 12 prepubertal prepubertal JJ cord-028721-x6f26ahr 1251 13 pattern pattern NN cord-028721-x6f26ahr 1251 14 ( ( -LRB- cord-028721-x6f26ahr 1251 15 very very RB cord-028721-x6f26ahr 1251 16 small small JJ cord-028721-x6f26ahr 1251 17 diameter diameter NN cord-028721-x6f26ahr 1251 18 and and CC cord-028721-x6f26ahr 1251 19 total total JJ cord-028721-x6f26ahr 1251 20 absence absence NN cord-028721-x6f26ahr 1251 21 of of IN cord-028721-x6f26ahr 1251 22 maturation maturation NN cord-028721-x6f26ahr 1251 23 ) ) -RRB- cord-028721-x6f26ahr 1251 24 are be VBP cord-028721-x6f26ahr 1251 25 present present JJ cord-028721-x6f26ahr 1251 26 and and CC cord-028721-x6f26ahr 1251 27 are be VBP cord-028721-x6f26ahr 1251 28 considered consider VBN cord-028721-x6f26ahr 1251 29 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1251 30 , , , cord-028721-x6f26ahr 1251 31 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1251 32 , , , cord-028721-x6f26ahr 1251 33 or or CC cord-028721-x6f26ahr 1251 34 hamartomatous hamartomatous JJ cord-028721-x6f26ahr 1251 35 . . . cord-028721-x6f26ahr 1252 1 Areas area NNS cord-028721-x6f26ahr 1252 2 of of IN cord-028721-x6f26ahr 1252 3 apparent apparent JJ cord-028721-x6f26ahr 1253 1 Leydig leydig NN cord-028721-x6f26ahr 1253 2 cell cell NN cord-028721-x6f26ahr 1253 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1253 4 are be VBP cord-028721-x6f26ahr 1253 5 frequent frequent JJ cord-028721-x6f26ahr 1253 6 , , , cord-028721-x6f26ahr 1253 7 and and CC cord-028721-x6f26ahr 1253 8 many many JJ cord-028721-x6f26ahr 1253 9 of of IN cord-028721-x6f26ahr 1253 10 these these DT cord-028721-x6f26ahr 1253 11 cells cell NNS cord-028721-x6f26ahr 1253 12 contain contain VBP cord-028721-x6f26ahr 1253 13 vacuolated vacuolated JJ cord-028721-x6f26ahr 1253 14 lipid lipid NN cord-028721-x6f26ahr 1253 15 - - HYPH cord-028721-x6f26ahr 1253 16 laden laden NN cord-028721-x6f26ahr 1253 17 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1253 18 ( ( -LRB- cord-028721-x6f26ahr 1253 19 Fig Fig NNP cord-028721-x6f26ahr 1253 20 . . . cord-028721-x6f26ahr 1253 21 12 12 CD cord-028721-x6f26ahr 1253 22 - - SYM cord-028721-x6f26ahr 1253 23 56 56 CD cord-028721-x6f26ahr 1253 24 ) ) -RRB- cord-028721-x6f26ahr 1253 25 . . . cord-028721-x6f26ahr 1254 1 The the DT cord-028721-x6f26ahr 1254 2 rete rete NN cord-028721-x6f26ahr 1254 3 testis testis NN cord-028721-x6f26ahr 1254 4 is be VBZ cord-028721-x6f26ahr 1254 5 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1254 6 in in IN cord-028721-x6f26ahr 1254 7 most most JJS cord-028721-x6f26ahr 1254 8 cases case NNS cord-028721-x6f26ahr 1254 9 and and CC cord-028721-x6f26ahr 1254 10 is be VBZ cord-028721-x6f26ahr 1254 11 lined line VBN cord-028721-x6f26ahr 1254 12 by by IN cord-028721-x6f26ahr 1254 13 columnar columnar JJ cord-028721-x6f26ahr 1254 14 epithelium epithelium NN cord-028721-x6f26ahr 1254 15 with with IN cord-028721-x6f26ahr 1254 16 rare rare JJ cord-028721-x6f26ahr 1254 17 areas area NNS cord-028721-x6f26ahr 1254 18 of of IN cord-028721-x6f26ahr 1254 19 fl fl NNP cord-028721-x6f26ahr 1254 20 attened attene VBD cord-028721-x6f26ahr 1254 21 cells cell NNS cord-028721-x6f26ahr 1254 22 . . . cord-028721-x6f26ahr 1255 1 Cystic cystic JJ cord-028721-x6f26ahr 1255 2 dilation dilation NN cord-028721-x6f26ahr 1255 3 is be VBZ cord-028721-x6f26ahr 1255 4 common common JJ cord-028721-x6f26ahr 1255 5 , , , cord-028721-x6f26ahr 1255 6 and and CC cord-028721-x6f26ahr 1255 7 adenomatous adenomatous JJ cord-028721-x6f26ahr 1255 8 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1255 9 has have VBZ cord-028721-x6f26ahr 1255 10 been be VBN cord-028721-x6f26ahr 1255 11 found find VBN cord-028721-x6f26ahr 1255 12 in in IN cord-028721-x6f26ahr 1255 13 some some DT cord-028721-x6f26ahr 1255 14 cases case NNS cord-028721-x6f26ahr 1255 15 . . . cord-028721-x6f26ahr 1256 1 Near near IN cord-028721-x6f26ahr 1256 2 the the DT cord-028721-x6f26ahr 1256 3 rete rete NN cord-028721-x6f26ahr 1256 4 testis testis NN cord-028721-x6f26ahr 1256 5 , , , cord-028721-x6f26ahr 1256 6 the the DT cord-028721-x6f26ahr 1256 7 testicular testicular JJ cord-028721-x6f26ahr 1256 8 parenchyma parenchyma NNS cord-028721-x6f26ahr 1256 9 frequently frequently RB cord-028721-x6f26ahr 1256 10 contains contain VBZ cord-028721-x6f26ahr 1256 11 metaplastic metaplastic JJ cord-028721-x6f26ahr 1256 12 fat fat NN cord-028721-x6f26ahr 1256 13 . . . cord-028721-x6f26ahr 1257 1 In in IN cord-028721-x6f26ahr 1257 2 some some DT cord-028721-x6f26ahr 1257 3 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1257 4 testes testis NNS cord-028721-x6f26ahr 1257 5 , , , cord-028721-x6f26ahr 1257 6 several several JJ cord-028721-x6f26ahr 1257 7 tubular tubular JJ cord-028721-x6f26ahr 1257 8 segments segment NNS cord-028721-x6f26ahr 1257 9 are be VBP cord-028721-x6f26ahr 1257 10 destroyed destroy VBN cord-028721-x6f26ahr 1257 11 by by IN cord-028721-x6f26ahr 1257 12 infl infl NN cord-028721-x6f26ahr 1257 13 ammation ammation NN cord-028721-x6f26ahr 1257 14 that that WDT cord-028721-x6f26ahr 1257 15 probably probably RB cord-028721-x6f26ahr 1257 16 has have VBZ cord-028721-x6f26ahr 1257 17 an an DT cord-028721-x6f26ahr 1257 18 autoimmune autoimmune JJ cord-028721-x6f26ahr 1257 19 cause cause NN cord-028721-x6f26ahr 1257 20 ( ( -LRB- cord-028721-x6f26ahr 1257 21 focal focal JJ cord-028721-x6f26ahr 1257 22 orchitis orchitis NN cord-028721-x6f26ahr 1257 23 ) ) -RRB- cord-028721-x6f26ahr 1257 24 . . . cord-028721-x6f26ahr 1258 1 536 536 CD cord-028721-x6f26ahr 1258 2 Epididymal Epididymal NNP cord-028721-x6f26ahr 1258 3 tubules tubule NNS cord-028721-x6f26ahr 1258 4 are be VBP cord-028721-x6f26ahr 1258 5 poorly poorly RB cord-028721-x6f26ahr 1258 6 developed develop VBN cord-028721-x6f26ahr 1258 7 and and CC cord-028721-x6f26ahr 1258 8 peritubular peritubular JJ cord-028721-x6f26ahr 1258 9 tissue tissue NN cord-028721-x6f26ahr 1258 10 is be VBZ cord-028721-x6f26ahr 1258 11 immature immature JJ cord-028721-x6f26ahr 1258 12 . . . cord-028721-x6f26ahr 1259 1 Blood blood NN cord-028721-x6f26ahr 1259 2 fl fl NNP cord-028721-x6f26ahr 1260 1 ow ow UH cord-028721-x6f26ahr 1260 2 is be VBZ cord-028721-x6f26ahr 1260 3 associated associate VBN cord-028721-x6f26ahr 1260 4 with with IN cord-028721-x6f26ahr 1260 5 testicular testicular JJ cord-028721-x6f26ahr 1260 6 histology histology NN cord-028721-x6f26ahr 1260 7 . . . cord-028721-x6f26ahr 1261 1 For for IN cord-028721-x6f26ahr 1261 2 example example NN cord-028721-x6f26ahr 1261 3 , , , cord-028721-x6f26ahr 1261 4 testicular testicular JJ cord-028721-x6f26ahr 1261 5 volume volume NN cord-028721-x6f26ahr 1261 6 , , , cord-028721-x6f26ahr 1261 7 histologic histologic JJ cord-028721-x6f26ahr 1261 8 pattern pattern NN cord-028721-x6f26ahr 1261 9 , , , cord-028721-x6f26ahr 1261 10 and and CC cord-028721-x6f26ahr 1261 11 testicular testicular JJ cord-028721-x6f26ahr 1261 12 artery artery NN cord-028721-x6f26ahr 1261 13 resistive resistive JJ cord-028721-x6f26ahr 1261 14 index index NN cord-028721-x6f26ahr 1261 15 are be VBP cord-028721-x6f26ahr 1261 16 lower low JJR cord-028721-x6f26ahr 1261 17 in in IN cord-028721-x6f26ahr 1261 18 undescended undescended JJ cord-028721-x6f26ahr 1261 19 testes testis NNS cord-028721-x6f26ahr 1261 20 than than IN cord-028721-x6f26ahr 1261 21 in in IN cord-028721-x6f26ahr 1261 22 controls control NNS cord-028721-x6f26ahr 1261 23 , , , cord-028721-x6f26ahr 1261 24 and and CC cord-028721-x6f26ahr 1261 25 testicular testicular JJ cord-028721-x6f26ahr 1261 26 artery artery NN cord-028721-x6f26ahr 1261 27 resistive resistive JJ cord-028721-x6f26ahr 1261 28 index index NN cord-028721-x6f26ahr 1261 29 is be VBZ cord-028721-x6f26ahr 1261 30 inversely inversely RB cord-028721-x6f26ahr 1261 31 proportional proportional JJ cord-028721-x6f26ahr 1261 32 to to IN cord-028721-x6f26ahr 1261 33 testicular testicular JJ cord-028721-x6f26ahr 1261 34 histology histology NN cord-028721-x6f26ahr 1261 35 score score NN cord-028721-x6f26ahr 1261 36 in in IN cord-028721-x6f26ahr 1261 37 undescended undescended JJ cord-028721-x6f26ahr 1261 38 testes testis NNS cord-028721-x6f26ahr 1261 39 . . . cord-028721-x6f26ahr 1262 1 537 537 CD cord-028721-x6f26ahr 1263 1 There there EX cord-028721-x6f26ahr 1263 2 is be VBZ cord-028721-x6f26ahr 1263 3 also also RB cord-028721-x6f26ahr 1263 4 an an DT cord-028721-x6f26ahr 1263 5 apparent apparent JJ cord-028721-x6f26ahr 1263 6 correlation correlation NN cord-028721-x6f26ahr 1263 7 between between IN cord-028721-x6f26ahr 1263 8 testicular testicular JJ cord-028721-x6f26ahr 1263 9 size size NN cord-028721-x6f26ahr 1263 10 , , , cord-028721-x6f26ahr 1263 11 spermiogram spermiogram NNP cord-028721-x6f26ahr 1263 12 , , , cord-028721-x6f26ahr 1263 13 and and CC cord-028721-x6f26ahr 1263 14 hormone hormone NN cord-028721-x6f26ahr 1263 15 levels level NNS cord-028721-x6f26ahr 1263 16 . . . cord-028721-x6f26ahr 1264 1 Assuming assume VBG cord-028721-x6f26ahr 1264 2 that that IN cord-028721-x6f26ahr 1264 3 a a DT cord-028721-x6f26ahr 1264 4 signifi signifi NN cord-028721-x6f26ahr 1264 5 ca can MD cord-028721-x6f26ahr 1264 6 nt not RB cord-028721-x6f26ahr 1264 7 reduction reduction VB cord-028721-x6f26ahr 1264 8 in in IN cord-028721-x6f26ahr 1264 9 testicular testicular JJ cord-028721-x6f26ahr 1264 10 size size NN cord-028721-x6f26ahr 1264 11 ( ( -LRB- cord-028721-x6f26ahr 1264 12 > > NFP cord-028721-x6f26ahr 1264 13 12 12 CD cord-028721-x6f26ahr 1264 14 mL ml NN cord-028721-x6f26ahr 1264 15 ) ) -RRB- cord-028721-x6f26ahr 1264 16 is be VBZ cord-028721-x6f26ahr 1264 17 only only RB cord-028721-x6f26ahr 1264 18 observed observe VBN cord-028721-x6f26ahr 1264 19 in in IN cord-028721-x6f26ahr 1264 20 9.3 9.3 CD cord-028721-x6f26ahr 1264 21 % % NN cord-028721-x6f26ahr 1264 22 of of IN cord-028721-x6f26ahr 1264 23 cases case NNS cord-028721-x6f26ahr 1264 24 , , , cord-028721-x6f26ahr 1264 25 and and CC cord-028721-x6f26ahr 1264 26 that that IN cord-028721-x6f26ahr 1264 27 serum serum NN cord-028721-x6f26ahr 1264 28 levels level NNS cord-028721-x6f26ahr 1264 29 of of IN cord-028721-x6f26ahr 1264 30 FSH fsh NN cord-028721-x6f26ahr 1264 31 , , , cord-028721-x6f26ahr 1264 32 LH LH NNP cord-028721-x6f26ahr 1264 33 , , , cord-028721-x6f26ahr 1264 34 and and CC cord-028721-x6f26ahr 1264 35 testosterone testosterone NN cord-028721-x6f26ahr 1264 36 are be VBP cord-028721-x6f26ahr 1264 37 normal normal JJ cord-028721-x6f26ahr 1264 38 , , , cord-028721-x6f26ahr 1264 39 an an DT cord-028721-x6f26ahr 1264 40 inverse inverse JJ cord-028721-x6f26ahr 1264 41 correlation correlation NN cord-028721-x6f26ahr 1264 42 is be VBZ cord-028721-x6f26ahr 1264 43 seen see VBN cord-028721-x6f26ahr 1264 44 between between IN cord-028721-x6f26ahr 1264 45 FSH fsh NN cord-028721-x6f26ahr 1264 46 and and CC cord-028721-x6f26ahr 1264 47 testicular testicular NN cord-028721-x6f26ahr 1264 48 volume volume NN cord-028721-x6f26ahr 1264 49 , , , cord-028721-x6f26ahr 1264 50 sperm sperm NN cord-028721-x6f26ahr 1264 51 concentration concentration NN cord-028721-x6f26ahr 1264 52 , , , cord-028721-x6f26ahr 1264 53 sperm sperm NN cord-028721-x6f26ahr 1264 54 motility motility NN cord-028721-x6f26ahr 1264 55 , , , cord-028721-x6f26ahr 1264 56 and and CC cord-028721-x6f26ahr 1264 57 normally normally RB cord-028721-x6f26ahr 1264 58 shaped shape VBN cord-028721-x6f26ahr 1264 59 sperm sperm NN cord-028721-x6f26ahr 1264 60 . . . cord-028721-x6f26ahr 1265 1 In in IN cord-028721-x6f26ahr 1265 2 addition addition NN cord-028721-x6f26ahr 1265 3 , , , cord-028721-x6f26ahr 1265 4 there there EX cord-028721-x6f26ahr 1265 5 is be VBZ cord-028721-x6f26ahr 1265 6 a a DT cord-028721-x6f26ahr 1265 7 direct direct JJ cord-028721-x6f26ahr 1265 8 relation relation NN cord-028721-x6f26ahr 1265 9 between between IN cord-028721-x6f26ahr 1265 10 testicular testicular JJ cord-028721-x6f26ahr 1265 11 volume volume NN cord-028721-x6f26ahr 1265 12 and and CC cord-028721-x6f26ahr 1265 13 sperm sperm NN cord-028721-x6f26ahr 1265 14 concentration concentration NN cord-028721-x6f26ahr 1265 15 , , , cord-028721-x6f26ahr 1265 16 sperm sperm NN cord-028721-x6f26ahr 1265 17 motility motility NN cord-028721-x6f26ahr 1265 18 , , , cord-028721-x6f26ahr 1265 19 and and CC cord-028721-x6f26ahr 1265 20 normally normally RB cord-028721-x6f26ahr 1265 21 shaped shape VBN cord-028721-x6f26ahr 1265 22 sperm sperm NN cord-028721-x6f26ahr 1265 23 . . . cord-028721-x6f26ahr 1266 1 These these DT cord-028721-x6f26ahr 1266 2 fi fi NNP cord-028721-x6f26ahr 1266 3 ndings nding NNS cord-028721-x6f26ahr 1266 4 indicate indicate VBP cord-028721-x6f26ahr 1266 5 the the DT cord-028721-x6f26ahr 1266 6 cause cause NN cord-028721-x6f26ahr 1266 7 of of IN cord-028721-x6f26ahr 1266 8 tubular tubular JJ cord-028721-x6f26ahr 1266 9 impairment impairment NN cord-028721-x6f26ahr 1266 10 in in IN cord-028721-x6f26ahr 1266 11 young young JJ cord-028721-x6f26ahr 1266 12 men man NNS cord-028721-x6f26ahr 1266 13 operated operate VBD cord-028721-x6f26ahr 1266 14 on on IN cord-028721-x6f26ahr 1266 15 in in IN cord-028721-x6f26ahr 1266 16 childhood childhood NN cord-028721-x6f26ahr 1266 17 for for IN cord-028721-x6f26ahr 1266 18 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1266 19 . . . cord-028721-x6f26ahr 1267 1 538 538 CD cord-028721-x6f26ahr 1267 2 Obstructed obstructed JJ cord-028721-x6f26ahr 1267 3 testes testis NNS cord-028721-x6f26ahr 1267 4 are be VBP cord-028721-x6f26ahr 1267 5 located locate VBN cord-028721-x6f26ahr 1267 6 in in IN cord-028721-x6f26ahr 1267 7 the the DT cord-028721-x6f26ahr 1267 8 superfi superfi NNS cord-028721-x6f26ahr 1267 9 cial cial NNP cord-028721-x6f26ahr 1267 10 inguinal inguinal JJ cord-028721-x6f26ahr 1267 11 pouch pouch NN cord-028721-x6f26ahr 1267 12 ( ( -LRB- cord-028721-x6f26ahr 1267 13 Denis Denis NNP cord-028721-x6f26ahr 1267 14 - - HYPH cord-028721-x6f26ahr 1267 15 Browne Browne NNP cord-028721-x6f26ahr 1267 16 pouch pouch NN cord-028721-x6f26ahr 1267 17 ) ) -RRB- cord-028721-x6f26ahr 1267 18 and and CC cord-028721-x6f26ahr 1267 19 are be VBP cord-028721-x6f26ahr 1267 20 considered consider VBN cord-028721-x6f26ahr 1267 21 ectopic ectopic JJ cord-028721-x6f26ahr 1267 22 by by IN cord-028721-x6f26ahr 1267 23 some some DT cord-028721-x6f26ahr 1267 24 authors author NNS cord-028721-x6f26ahr 1267 25 and and CC cord-028721-x6f26ahr 1267 26 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1267 27 by by IN cord-028721-x6f26ahr 1267 28 others other NNS cord-028721-x6f26ahr 1267 29 . . . cord-028721-x6f26ahr 1268 1 539 539 CD cord-028721-x6f26ahr 1268 2 , , , cord-028721-x6f26ahr 1268 3 540 540 CD cord-028721-x6f26ahr 1268 4 Histologic Histologic NNP cord-028721-x6f26ahr 1268 5 studies study NNS cord-028721-x6f26ahr 1268 6 reveal reveal VBP cord-028721-x6f26ahr 1268 7 that that IN cord-028721-x6f26ahr 1268 8 most most RBS cord-028721-x6f26ahr 1268 9 obstructed obstruct VBN cord-028721-x6f26ahr 1268 10 testes testis NNS cord-028721-x6f26ahr 1268 11 bear bear VBP cord-028721-x6f26ahr 1268 12 the the DT cord-028721-x6f26ahr 1268 13 same same JJ cord-028721-x6f26ahr 1268 14 lesions lesion NNS cord-028721-x6f26ahr 1268 15 as as IN cord-028721-x6f26ahr 1268 16 true true JJ cord-028721-x6f26ahr 1268 17 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1268 18 testes testis NNS cord-028721-x6f26ahr 1268 19 . . . cord-028721-x6f26ahr 1269 1 Type type NN cord-028721-x6f26ahr 1269 2 I -PRON- PRP cord-028721-x6f26ahr 1269 3 lesions lesion NNS cord-028721-x6f26ahr 1269 4 are be VBP cord-028721-x6f26ahr 1269 5 observed observe VBN cord-028721-x6f26ahr 1269 6 in in IN cord-028721-x6f26ahr 1269 7 half half NN cord-028721-x6f26ahr 1269 8 , , , cord-028721-x6f26ahr 1269 9 type type NN cord-028721-x6f26ahr 1269 10 II II NNP cord-028721-x6f26ahr 1269 11 in in IN cord-028721-x6f26ahr 1269 12 more more JJR cord-028721-x6f26ahr 1269 13 than than IN cord-028721-x6f26ahr 1269 14 one one CD cord-028721-x6f26ahr 1269 15 - - HYPH cord-028721-x6f26ahr 1269 16 third third NN cord-028721-x6f26ahr 1269 17 , , , cord-028721-x6f26ahr 1269 18 and and CC cord-028721-x6f26ahr 1269 19 the the DT cord-028721-x6f26ahr 1269 20 remainder remainder NN cord-028721-x6f26ahr 1269 21 show show NN cord-028721-x6f26ahr 1269 22 type type NN cord-028721-x6f26ahr 1269 23 III iii CD cord-028721-x6f26ahr 1269 24 lesions lesion NNS cord-028721-x6f26ahr 1269 25 . . . cord-028721-x6f26ahr 1270 1 The the DT cord-028721-x6f26ahr 1270 2 higher high JJR cord-028721-x6f26ahr 1270 3 proportion proportion NN cord-028721-x6f26ahr 1270 4 of of IN cord-028721-x6f26ahr 1270 5 type type NN cord-028721-x6f26ahr 1270 6 I -PRON- PRP cord-028721-x6f26ahr 1270 7 lesions lesion NNS cord-028721-x6f26ahr 1270 8 suggests suggest VBZ cord-028721-x6f26ahr 1270 9 a a DT cord-028721-x6f26ahr 1270 10 better well JJR cord-028721-x6f26ahr 1270 11 prognosis prognosis NN cord-028721-x6f26ahr 1270 12 than than IN cord-028721-x6f26ahr 1270 13 in in IN cord-028721-x6f26ahr 1270 14 true true JJ cord-028721-x6f26ahr 1270 15 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1270 16 testes testis NNS cord-028721-x6f26ahr 1270 17 . . . cord-028721-x6f26ahr 1271 1 Some some DT cord-028721-x6f26ahr 1271 2 authors author NNS cord-028721-x6f26ahr 1271 3 assume assume VBP cord-028721-x6f26ahr 1271 4 that that IN cord-028721-x6f26ahr 1271 5 retractile retractile JJ cord-028721-x6f26ahr 1271 6 testes testis NNS cord-028721-x6f26ahr 1271 7 are be VBP cord-028721-x6f26ahr 1271 8 normal normal JJ cord-028721-x6f26ahr 1271 9 and and CC cord-028721-x6f26ahr 1271 10 exclude exclude VB cord-028721-x6f26ahr 1271 11 them -PRON- PRP cord-028721-x6f26ahr 1271 12 from from IN cord-028721-x6f26ahr 1271 13 studies study NNS cord-028721-x6f26ahr 1271 14 of of IN cord-028721-x6f26ahr 1271 15 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1271 16 . . . cord-028721-x6f26ahr 1272 1 541 541 CD cord-028721-x6f26ahr 1272 2 , , , cord-028721-x6f26ahr 1272 3 542 542 CD cord-028721-x6f26ahr 1273 1 However however RB cord-028721-x6f26ahr 1273 2 , , , cord-028721-x6f26ahr 1273 3 these these DT cord-028721-x6f26ahr 1273 4 testes testis NNS cord-028721-x6f26ahr 1273 5 may may MD cord-028721-x6f26ahr 1273 6 present present VB cord-028721-x6f26ahr 1273 7 important important JJ cord-028721-x6f26ahr 1273 8 lesions lesion NNS cord-028721-x6f26ahr 1273 9 and and CC cord-028721-x6f26ahr 1273 10 many many JJ cord-028721-x6f26ahr 1273 11 consider consider VBP cord-028721-x6f26ahr 1273 12 them -PRON- PRP cord-028721-x6f26ahr 1273 13 to to TO cord-028721-x6f26ahr 1273 14 be be VB cord-028721-x6f26ahr 1273 15 a a DT cord-028721-x6f26ahr 1273 16 form form NN cord-028721-x6f26ahr 1273 17 of of IN cord-028721-x6f26ahr 1273 18 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1273 19 . . . cord-028721-x6f26ahr 1274 1 [ [ -LRB- cord-028721-x6f26ahr 1274 2 543 543 CD cord-028721-x6f26ahr 1274 3 ] ] -RRB- cord-028721-x6f26ahr 1274 4 [ [ -LRB- cord-028721-x6f26ahr 1274 5 544 544 CD cord-028721-x6f26ahr 1274 6 ] ] -RRB- cord-028721-x6f26ahr 1275 1 [ [ -LRB- cord-028721-x6f26ahr 1275 2 545 545 CD cord-028721-x6f26ahr 1275 3 ] ] -RRB- cord-028721-x6f26ahr 1276 1 Retractile Retractile NNP cord-028721-x6f26ahr 1276 2 testes testis NNS cord-028721-x6f26ahr 1276 3 may may MD cord-028721-x6f26ahr 1276 4 not not RB cord-028721-x6f26ahr 1276 5 always always RB cord-028721-x6f26ahr 1276 6 be be VB cord-028721-x6f26ahr 1276 7 movable movable JJ cord-028721-x6f26ahr 1276 8 to to IN cord-028721-x6f26ahr 1276 9 the the DT cord-028721-x6f26ahr 1276 10 lower low JJR cord-028721-x6f26ahr 1276 11 scrotum scrotum NN cord-028721-x6f26ahr 1276 12 ( ( -LRB- cord-028721-x6f26ahr 1276 13 70 70 CD cord-028721-x6f26ahr 1276 14 - - SYM cord-028721-x6f26ahr 1276 15 75 75 CD cord-028721-x6f26ahr 1276 16 mm mm NN cord-028721-x6f26ahr 1276 17 from from IN cord-028721-x6f26ahr 1276 18 the the DT cord-028721-x6f26ahr 1276 19 pubic pubic NNP cord-028721-x6f26ahr 1276 20 tubercle tubercle NN cord-028721-x6f26ahr 1276 21 ) ) -RRB- cord-028721-x6f26ahr 1276 22 and and CC cord-028721-x6f26ahr 1276 23 in in IN cord-028721-x6f26ahr 1276 24 50 50 CD cord-028721-x6f26ahr 1276 25 % % NN cord-028721-x6f26ahr 1276 26 of of IN cord-028721-x6f26ahr 1276 27 cases case NNS cord-028721-x6f26ahr 1276 28 are be VBP cord-028721-x6f26ahr 1276 29 smaller small JJR cord-028721-x6f26ahr 1276 30 than than IN cord-028721-x6f26ahr 1276 31 scrotal scrotal JJ cord-028721-x6f26ahr 1276 32 testes testis NNS cord-028721-x6f26ahr 1276 33 . . . cord-028721-x6f26ahr 1277 1 Approximately approximately RB cord-028721-x6f26ahr 1277 2 50 50 CD cord-028721-x6f26ahr 1277 3 % % NN cord-028721-x6f26ahr 1277 4 of of IN cord-028721-x6f26ahr 1277 5 retractile retractile JJ cord-028721-x6f26ahr 1277 6 testes testis NNS cord-028721-x6f26ahr 1277 7 remain remain VBP cord-028721-x6f26ahr 1277 8 high high JJ cord-028721-x6f26ahr 1277 9 after after IN cord-028721-x6f26ahr 1277 10 age age NN cord-028721-x6f26ahr 1277 11 6 6 CD cord-028721-x6f26ahr 1277 12 years year NNS cord-028721-x6f26ahr 1277 13 , , , cord-028721-x6f26ahr 1277 14 when when WRB cord-028721-x6f26ahr 1277 15 cremasteric cremasteric JJ cord-028721-x6f26ahr 1277 16 activity activity NN cord-028721-x6f26ahr 1277 17 declines decline VBZ cord-028721-x6f26ahr 1277 18 . . . cord-028721-x6f26ahr 1278 1 546 546 CD cord-028721-x6f26ahr 1279 1 Retractile Retractile NNP cord-028721-x6f26ahr 1279 2 testes testis NNS cord-028721-x6f26ahr 1279 3 have have VBP cord-028721-x6f26ahr 1279 4 a a DT cord-028721-x6f26ahr 1279 5 32 32 CD cord-028721-x6f26ahr 1279 6 % % NN cord-028721-x6f26ahr 1279 7 risk risk NN cord-028721-x6f26ahr 1279 8 of of IN cord-028721-x6f26ahr 1279 9 becoming become VBG cord-028721-x6f26ahr 1279 10 ascending ascend VBG cord-028721-x6f26ahr 1279 11 or or CC cord-028721-x6f26ahr 1279 12 acquired acquire VBN cord-028721-x6f26ahr 1279 13 undescended undescended JJ cord-028721-x6f26ahr 1279 14 testes testis NNS cord-028721-x6f26ahr 1279 15 . . . cord-028721-x6f26ahr 1280 1 The the DT cord-028721-x6f26ahr 1280 2 risk risk NN cord-028721-x6f26ahr 1280 3 is be VBZ cord-028721-x6f26ahr 1280 4 higher high JJR cord-028721-x6f26ahr 1280 5 in in IN cord-028721-x6f26ahr 1280 6 boys boy NNS cord-028721-x6f26ahr 1280 7 younger young JJR cord-028721-x6f26ahr 1280 8 than than IN cord-028721-x6f26ahr 1280 9 7 7 CD cord-028721-x6f26ahr 1280 10 years year NNS cord-028721-x6f26ahr 1280 11 , , , cord-028721-x6f26ahr 1280 12 or or CC cord-028721-x6f26ahr 1280 13 when when WRB cord-028721-x6f26ahr 1280 14 the the DT cord-028721-x6f26ahr 1280 15 spermatic spermatic JJ cord-028721-x6f26ahr 1280 16 cord cord NN cord-028721-x6f26ahr 1280 17 is be VBZ cord-028721-x6f26ahr 1280 18 tight tight JJ cord-028721-x6f26ahr 1280 19 or or CC cord-028721-x6f26ahr 1280 20 inelastic inelastic JJ cord-028721-x6f26ahr 1280 21 . . . cord-028721-x6f26ahr 1281 1 547 547 CD cord-028721-x6f26ahr 1282 1 During during IN cord-028721-x6f26ahr 1282 2 childhood childhood NN cord-028721-x6f26ahr 1282 3 , , , cord-028721-x6f26ahr 1282 4 tubular tubular JJ cord-028721-x6f26ahr 1282 5 diameter diameter NN cord-028721-x6f26ahr 1282 6 and and CC cord-028721-x6f26ahr 1282 7 tubular tubular JJ cord-028721-x6f26ahr 1282 8 fertility fertility NN cord-028721-x6f26ahr 1282 9 index index NN cord-028721-x6f26ahr 1282 10 decrease decrease NN cord-028721-x6f26ahr 1282 11 . . . cord-028721-x6f26ahr 1283 1 544 544 CD cord-028721-x6f26ahr 1283 2 Adults Adults NNPS cord-028721-x6f26ahr 1283 3 with with IN cord-028721-x6f26ahr 1283 4 retractile retractile JJ cord-028721-x6f26ahr 1283 5 testes testis NNS cord-028721-x6f26ahr 1283 6 that that WDT cord-028721-x6f26ahr 1283 7 descended descend VBD cord-028721-x6f26ahr 1283 8 spontaneously spontaneously RB cord-028721-x6f26ahr 1283 9 but but CC cord-028721-x6f26ahr 1283 10 late late JJ cord-028721-x6f26ahr 1283 11 may may MD cord-028721-x6f26ahr 1283 12 be be VB cord-028721-x6f26ahr 1283 13 fertile fertile JJ cord-028721-x6f26ahr 1283 14 548 548 CD cord-028721-x6f26ahr 1283 15 or or CC cord-028721-x6f26ahr 1283 16 infertile infertile JJ cord-028721-x6f26ahr 1283 17 . . . cord-028721-x6f26ahr 1284 1 549 549 CD cord-028721-x6f26ahr 1285 1 Usually usually RB cord-028721-x6f26ahr 1285 2 there there EX cord-028721-x6f26ahr 1285 3 is be VBZ cord-028721-x6f26ahr 1285 4 germ germ NN cord-028721-x6f26ahr 1285 5 cell cell NN cord-028721-x6f26ahr 1285 6 atrophy atrophy NN cord-028721-x6f26ahr 1285 7 that that WDT cord-028721-x6f26ahr 1285 8 varies vary VBZ cord-028721-x6f26ahr 1285 9 in in IN cord-028721-x6f26ahr 1285 10 severity severity NN cord-028721-x6f26ahr 1285 11 from from IN cord-028721-x6f26ahr 1285 12 lobule lobule NN cord-028721-x6f26ahr 1285 13 to to IN cord-028721-x6f26ahr 1285 14 lobule lobule NN cord-028721-x6f26ahr 1285 15 . . . cord-028721-x6f26ahr 1286 1 544 544 CD cord-028721-x6f26ahr 1286 2 Regular regular JJ cord-028721-x6f26ahr 1286 3 examination examination NN cord-028721-x6f26ahr 1286 4 of of IN cord-028721-x6f26ahr 1286 5 retractile retractile JJ cord-028721-x6f26ahr 1286 6 testes testis NNS cord-028721-x6f26ahr 1286 7 is be VBZ cord-028721-x6f26ahr 1286 8 advisable advisable JJ cord-028721-x6f26ahr 1286 9 during during IN cord-028721-x6f26ahr 1286 10 childhood childhood NN cord-028721-x6f26ahr 1286 11 and and CC cord-028721-x6f26ahr 1286 12 , , , cord-028721-x6f26ahr 1286 13 if if IN cord-028721-x6f26ahr 1286 14 complete complete JJ cord-028721-x6f26ahr 1286 15 testicular testicular JJ cord-028721-x6f26ahr 1286 16 descent descent NN cord-028721-x6f26ahr 1286 17 does do VBZ cord-028721-x6f26ahr 1286 18 not not RB cord-028721-x6f26ahr 1286 19 occur occur VB cord-028721-x6f26ahr 1286 20 , , , cord-028721-x6f26ahr 1286 21 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 1286 22 is be VBZ cord-028721-x6f26ahr 1286 23 indicated indicate VBN cord-028721-x6f26ahr 1286 24 . . . cord-028721-x6f26ahr 1287 1 Most Most JJS cord-028721-x6f26ahr 1287 2 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1287 3 patients patient NNS cord-028721-x6f26ahr 1287 4 have have VBP cord-028721-x6f26ahr 1287 5 a a DT cord-028721-x6f26ahr 1287 6 patent patent NN cord-028721-x6f26ahr 1287 7 processus processus NNP cord-028721-x6f26ahr 1287 8 vaginalis vaginalis NNP cord-028721-x6f26ahr 1287 9 , , , cord-028721-x6f26ahr 1287 10 and and CC cord-028721-x6f26ahr 1287 11 65 65 CD cord-028721-x6f26ahr 1287 12 - - SYM cord-028721-x6f26ahr 1287 13 75 75 CD cord-028721-x6f26ahr 1287 14 % % NN cord-028721-x6f26ahr 1287 15 have have VBP cord-028721-x6f26ahr 1287 16 a a DT cord-028721-x6f26ahr 1287 17 hernia hernia NN cord-028721-x6f26ahr 1287 18 sac sac NN cord-028721-x6f26ahr 1287 19 , , , cord-028721-x6f26ahr 1287 20 although although IN cord-028721-x6f26ahr 1287 21 most most JJS cord-028721-x6f26ahr 1287 22 hernias hernia NNS cord-028721-x6f26ahr 1287 23 are be VBP cord-028721-x6f26ahr 1287 24 not not RB cord-028721-x6f26ahr 1287 25 clinically clinically RB cord-028721-x6f26ahr 1287 26 visible visible JJ cord-028721-x6f26ahr 1287 27 . . . cord-028721-x6f26ahr 1288 1 Urologic urologic JJ cord-028721-x6f26ahr 1288 2 anomalies anomaly NNS cord-028721-x6f26ahr 1288 3 are be VBP cord-028721-x6f26ahr 1288 4 present present JJ cord-028721-x6f26ahr 1288 5 in in IN cord-028721-x6f26ahr 1288 6 10.5 10.5 CD cord-028721-x6f26ahr 1288 7 % % NN cord-028721-x6f26ahr 1288 8 of of IN cord-028721-x6f26ahr 1288 9 patients patient NNS cord-028721-x6f26ahr 1288 10 , , , cord-028721-x6f26ahr 1288 11 the the DT cord-028721-x6f26ahr 1288 12 most most RBS cord-028721-x6f26ahr 1288 13 frequent frequent JJ cord-028721-x6f26ahr 1288 14 being be VBG cord-028721-x6f26ahr 1288 15 hypospadias hypospadia NNS cord-028721-x6f26ahr 1288 16 , , , cord-028721-x6f26ahr 1288 17 complete complete JJ cord-028721-x6f26ahr 1288 18 duplication duplication NN cord-028721-x6f26ahr 1288 19 of of IN cord-028721-x6f26ahr 1288 20 the the DT cord-028721-x6f26ahr 1288 21 urinary urinary JJ cord-028721-x6f26ahr 1288 22 tract tract NN cord-028721-x6f26ahr 1288 23 , , , cord-028721-x6f26ahr 1288 24 non non JJ cord-028721-x6f26ahr 1288 25 - - JJ cord-028721-x6f26ahr 1288 26 obstructive obstructive JJ cord-028721-x6f26ahr 1288 27 ureteral ureteral JJ cord-028721-x6f26ahr 1288 28 dilatation dilatation NN cord-028721-x6f26ahr 1288 29 , , , cord-028721-x6f26ahr 1288 30 kidney kidney NN cord-028721-x6f26ahr 1288 31 malrotation malrotation NN cord-028721-x6f26ahr 1288 32 , , , cord-028721-x6f26ahr 1288 33 and and CC cord-028721-x6f26ahr 1288 34 posterior posterior JJ cord-028721-x6f26ahr 1288 35 urethral urethral JJ cord-028721-x6f26ahr 1288 36 valves valve NNS cord-028721-x6f26ahr 1288 37 . . . cord-028721-x6f26ahr 1289 1 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 1289 2 is be VBZ cord-028721-x6f26ahr 1289 3 more more RBR cord-028721-x6f26ahr 1289 4 frequent frequent JJ cord-028721-x6f26ahr 1289 5 in in IN cord-028721-x6f26ahr 1289 6 patients patient NNS cord-028721-x6f26ahr 1289 7 with with IN cord-028721-x6f26ahr 1289 8 microcephaly microcephaly NNS cord-028721-x6f26ahr 1289 9 , , , cord-028721-x6f26ahr 1289 10 myelomeningocele myelomeningocele NNP cord-028721-x6f26ahr 1289 11 , , , cord-028721-x6f26ahr 1289 12 bifi bifi NNP cord-028721-x6f26ahr 1289 13 d d NNP cord-028721-x6f26ahr 1289 14 spine spine NN cord-028721-x6f26ahr 1289 15 , , , cord-028721-x6f26ahr 1289 16 omphalocele omphalocele NNP cord-028721-x6f26ahr 1289 17 , , , cord-028721-x6f26ahr 1289 18 gastroschisis gastroschisis NNP cord-028721-x6f26ahr 1289 19 , , , cord-028721-x6f26ahr 1289 20 micropenis micropeni NNS cord-028721-x6f26ahr 1289 21 , , , cord-028721-x6f26ahr 1289 22 and and CC cord-028721-x6f26ahr 1289 23 imperforate imperforate JJ cord-028721-x6f26ahr 1289 24 anus anus NN cord-028721-x6f26ahr 1289 25 . . . cord-028721-x6f26ahr 1290 1 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 1290 2 may may MD cord-028721-x6f26ahr 1290 3 appear appear VB cord-028721-x6f26ahr 1290 4 isolated isolate VBN cord-028721-x6f26ahr 1290 5 or or CC cord-028721-x6f26ahr 1290 6 associated associate VBN cord-028721-x6f26ahr 1290 7 with with IN cord-028721-x6f26ahr 1290 8 congenital congenital JJ cord-028721-x6f26ahr 1290 9 anomalies anomaly NNS cord-028721-x6f26ahr 1290 10 , , , cord-028721-x6f26ahr 1290 11 endocrine endocrine JJ cord-028721-x6f26ahr 1290 12 dysfunction dysfunction NN cord-028721-x6f26ahr 1290 13 , , , cord-028721-x6f26ahr 1290 14 chromosomal chromosomal JJ cord-028721-x6f26ahr 1290 15 disorders disorder NNS cord-028721-x6f26ahr 1290 16 , , , cord-028721-x6f26ahr 1290 17 or or CC cord-028721-x6f26ahr 1290 18 intersex intersex NN cord-028721-x6f26ahr 1290 19 conditions condition NNS cord-028721-x6f26ahr 1290 20 . . . cord-028721-x6f26ahr 1291 1 Thus thus RB cord-028721-x6f26ahr 1291 2 , , , cord-028721-x6f26ahr 1291 3 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1291 4 is be VBZ cord-028721-x6f26ahr 1291 5 found find VBN cord-028721-x6f26ahr 1291 6 in in IN cord-028721-x6f26ahr 1291 7 the the DT cord-028721-x6f26ahr 1291 8 Kallmann Kallmann NNP cord-028721-x6f26ahr 1291 9 , , , cord-028721-x6f26ahr 1291 10 Prader Prader NNP cord-028721-x6f26ahr 1291 11 - - HYPH cord-028721-x6f26ahr 1291 12 Willi Willi NNP cord-028721-x6f26ahr 1291 13 , , , cord-028721-x6f26ahr 1291 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 1291 15 , , , cord-028721-x6f26ahr 1291 16 Noonan Noonan NNP cord-028721-x6f26ahr 1291 17 , , , cord-028721-x6f26ahr 1291 18 Smith Smith NNP cord-028721-x6f26ahr 1291 19 - - HYPH cord-028721-x6f26ahr 1291 20 Lemli Lemli NNP cord-028721-x6f26ahr 1291 21 - - HYPH cord-028721-x6f26ahr 1291 22 Opitz Opitz NNP cord-028721-x6f26ahr 1291 23 , , , cord-028721-x6f26ahr 1291 24 Aarskog Aarskog NNP cord-028721-x6f26ahr 1291 25 - - HYPH cord-028721-x6f26ahr 1291 26 Scott Scott NNP cord-028721-x6f26ahr 1291 27 , , , cord-028721-x6f26ahr 1291 28 Rubinstein Rubinstein NNP cord-028721-x6f26ahr 1291 29 - - HYPH cord-028721-x6f26ahr 1291 30 Taybi Taybi NNP cord-028721-x6f26ahr 1291 31 , , , cord-028721-x6f26ahr 1291 32 prune prune VB cord-028721-x6f26ahr 1291 33 belly belly NN cord-028721-x6f26ahr 1291 34 , , , cord-028721-x6f26ahr 1291 35 and and CC cord-028721-x6f26ahr 1291 36 caudal caudal JJ cord-028721-x6f26ahr 1291 37 regression regression NN cord-028721-x6f26ahr 1291 38 syndromes syndrome NNS cord-028721-x6f26ahr 1291 39 , , , cord-028721-x6f26ahr 1291 40 anomalies anomaly NNS cord-028721-x6f26ahr 1291 41 of of IN cord-028721-x6f26ahr 1291 42 the the DT cord-028721-x6f26ahr 1291 43 androgen androgen NN cord-028721-x6f26ahr 1291 44 receptor receptor NN cord-028721-x6f26ahr 1291 45 , , , cord-028721-x6f26ahr 1291 46 absence absence NN cord-028721-x6f26ahr 1291 47 of of IN cord-028721-x6f26ahr 1291 48 anti anti JJ cord-028721-x6f26ahr 1291 49 - - JJ cord-028721-x6f26ahr 1291 50 müllerian müllerian JJ cord-028721-x6f26ahr 1291 51 hormone hormone NN cord-028721-x6f26ahr 1291 52 , , , cord-028721-x6f26ahr 1291 53 CHARGE CHARGE NNP cord-028721-x6f26ahr 1291 54 association association NNP cord-028721-x6f26ahr 1291 55 , , , cord-028721-x6f26ahr 1291 56 and and CC cord-028721-x6f26ahr 1291 57 trisomies trisomy NNS cord-028721-x6f26ahr 1291 58 13 13 CD cord-028721-x6f26ahr 1291 59 , , , cord-028721-x6f26ahr 1291 60 18 18 CD cord-028721-x6f26ahr 1291 61 , , , cord-028721-x6f26ahr 1291 62 and and CC cord-028721-x6f26ahr 1291 63 21 21 CD cord-028721-x6f26ahr 1291 64 . . . cord-028721-x6f26ahr 1292 1 Sperm sperm JJ cord-028721-x6f26ahr 1292 2 excretory excretory JJ cord-028721-x6f26ahr 1292 3 duct duct NN cord-028721-x6f26ahr 1292 4 anomalies anomaly NNS cord-028721-x6f26ahr 1292 5 occur occur VBP cord-028721-x6f26ahr 1292 6 in in IN cord-028721-x6f26ahr 1292 7 9 9 CD cord-028721-x6f26ahr 1292 8 - - SYM cord-028721-x6f26ahr 1292 9 36 36 CD cord-028721-x6f26ahr 1292 10 % % NN cord-028721-x6f26ahr 1292 11 of of IN cord-028721-x6f26ahr 1292 12 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1292 13 patients patient NNS cord-028721-x6f26ahr 1292 14 , , , cord-028721-x6f26ahr 1292 15 550 550 CD cord-028721-x6f26ahr 1292 16 , , , cord-028721-x6f26ahr 1292 17 551 551 CD cord-028721-x6f26ahr 1292 18 and and CC cord-028721-x6f26ahr 1292 19 are be VBP cord-028721-x6f26ahr 1292 20 classifi classifi NNP cord-028721-x6f26ahr 1292 21 ed ed NN cord-028721-x6f26ahr 1292 22 into into IN cord-028721-x6f26ahr 1292 23 three three CD cord-028721-x6f26ahr 1292 24 types type NNS cord-028721-x6f26ahr 1292 25 : : : cord-028721-x6f26ahr 1292 26 552 552 CD cord-028721-x6f26ahr 1293 1 • • NNP cord-028721-x6f26ahr 1294 1 Ductal Ductal NNP cord-028721-x6f26ahr 1294 2 fusion fusion NN cord-028721-x6f26ahr 1294 3 anomalies anomaly NNS cord-028721-x6f26ahr 1294 4 ( ( -LRB- cord-028721-x6f26ahr 1294 5 25 25 CD cord-028721-x6f26ahr 1294 6 % % NN cord-028721-x6f26ahr 1294 7 of of IN cord-028721-x6f26ahr 1294 8 cases case NNS cord-028721-x6f26ahr 1294 9 ) ) -RRB- cord-028721-x6f26ahr 1294 10 . . . cord-028721-x6f26ahr 1295 1 These these DT cord-028721-x6f26ahr 1295 2 consist consist VBP cord-028721-x6f26ahr 1295 3 of of IN cord-028721-x6f26ahr 1295 4 anomalous anomalous JJ cord-028721-x6f26ahr 1295 5 fusion fusion NN cord-028721-x6f26ahr 1295 6 of of IN cord-028721-x6f26ahr 1295 7 the the DT cord-028721-x6f26ahr 1295 8 caput caput NN cord-028721-x6f26ahr 1295 9 of of IN cord-028721-x6f26ahr 1295 10 the the DT cord-028721-x6f26ahr 1295 11 epididymis epididymis NN cord-028721-x6f26ahr 1295 12 to to IN cord-028721-x6f26ahr 1295 13 the the DT cord-028721-x6f26ahr 1295 14 testis testis NN cord-028721-x6f26ahr 1295 15 or or CC cord-028721-x6f26ahr 1295 16 segmental segmental JJ cord-028721-x6f26ahr 1295 17 atresia atresia NN cord-028721-x6f26ahr 1295 18 of of IN cord-028721-x6f26ahr 1295 19 the the DT cord-028721-x6f26ahr 1295 20 epididymis epididymis NN cord-028721-x6f26ahr 1295 21 and and CC cord-028721-x6f26ahr 1295 22 vas vas NNP cord-028721-x6f26ahr 1295 23 deferens deferen NNS cord-028721-x6f26ahr 1295 24 . . . cord-028721-x6f26ahr 1296 1 This this DT cord-028721-x6f26ahr 1296 2 is be VBZ cord-028721-x6f26ahr 1296 3 chiefl chiefl NNP cord-028721-x6f26ahr 1296 4 y y NNP cord-028721-x6f26ahr 1296 5 associated associate VBN cord-028721-x6f26ahr 1296 6 with with IN cord-028721-x6f26ahr 1296 7 intraabdominal intraabdominal JJ cord-028721-x6f26ahr 1296 8 or or CC cord-028721-x6f26ahr 1296 9 high high JJ cord-028721-x6f26ahr 1296 10 scrotal scrotal JJ cord-028721-x6f26ahr 1296 11 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1296 12 testes testis NNS cord-028721-x6f26ahr 1296 13 . . . cord-028721-x6f26ahr 1297 1 • • NNP cord-028721-x6f26ahr 1298 1 Ductal Ductal NNP cord-028721-x6f26ahr 1298 2 suspension suspension NN cord-028721-x6f26ahr 1298 3 anomalies anomaly NNS cord-028721-x6f26ahr 1298 4 ( ( -LRB- cord-028721-x6f26ahr 1298 5 59 59 CD cord-028721-x6f26ahr 1298 6 % % NN cord-028721-x6f26ahr 1298 7 of of IN cord-028721-x6f26ahr 1298 8 cases case NNS cord-028721-x6f26ahr 1298 9 ) ) -RRB- cord-028721-x6f26ahr 1298 10 . . . cord-028721-x6f26ahr 1299 1 The the DT cord-028721-x6f26ahr 1299 2 caput caput NN cord-028721-x6f26ahr 1299 3 of of IN cord-028721-x6f26ahr 1299 4 the the DT cord-028721-x6f26ahr 1299 5 epididymis epididymis NN cord-028721-x6f26ahr 1299 6 is be VBZ cord-028721-x6f26ahr 1299 7 attached attach VBN cord-028721-x6f26ahr 1299 8 to to IN cord-028721-x6f26ahr 1299 9 the the DT cord-028721-x6f26ahr 1299 10 testis testis NN cord-028721-x6f26ahr 1299 11 , , , cord-028721-x6f26ahr 1299 12 whereas whereas IN cord-028721-x6f26ahr 1299 13 the the DT cord-028721-x6f26ahr 1299 14 corpus corpus NN cord-028721-x6f26ahr 1299 15 and and CC cord-028721-x6f26ahr 1299 16 the the DT cord-028721-x6f26ahr 1299 17 cauda cauda NN cord-028721-x6f26ahr 1299 18 of of IN cord-028721-x6f26ahr 1299 19 the the DT cord-028721-x6f26ahr 1299 20 epididymis epididymis NN cord-028721-x6f26ahr 1299 21 are be VBP cord-028721-x6f26ahr 1299 22 separated separate VBN cord-028721-x6f26ahr 1299 23 from from IN cord-028721-x6f26ahr 1299 24 the the DT cord-028721-x6f26ahr 1299 25 testis testis NN cord-028721-x6f26ahr 1299 26 by by IN cord-028721-x6f26ahr 1299 27 a a DT cord-028721-x6f26ahr 1299 28 mesentery mesentery NN cord-028721-x6f26ahr 1299 29 . . . cord-028721-x6f26ahr 1300 1 A a DT cord-028721-x6f26ahr 1300 2 variant variant NN cord-028721-x6f26ahr 1300 3 consists consist VBZ cord-028721-x6f26ahr 1300 4 of of IN cord-028721-x6f26ahr 1300 5 an an DT cord-028721-x6f26ahr 1300 6 excessively excessively RB cord-028721-x6f26ahr 1300 7 long long JJ cord-028721-x6f26ahr 1300 8 cauda cauda NN cord-028721-x6f26ahr 1300 9 of of IN cord-028721-x6f26ahr 1300 10 the the DT cord-028721-x6f26ahr 1300 11 epididymis epididymis NN cord-028721-x6f26ahr 1300 12 that that WDT cord-028721-x6f26ahr 1300 13 descends descend VBZ cord-028721-x6f26ahr 1300 14 along along IN cord-028721-x6f26ahr 1300 15 the the DT cord-028721-x6f26ahr 1300 16 inguinal inguinal JJ cord-028721-x6f26ahr 1300 17 duct duct NN cord-028721-x6f26ahr 1300 18 to to IN cord-028721-x6f26ahr 1300 19 the the DT cord-028721-x6f26ahr 1300 20 scrotum scrotum NN cord-028721-x6f26ahr 1300 21 . . . cord-028721-x6f26ahr 1301 1 • • NNP cord-028721-x6f26ahr 1302 1 Anomalies anomaly NNS cord-028721-x6f26ahr 1302 2 associated associate VBN cord-028721-x6f26ahr 1302 3 with with IN cord-028721-x6f26ahr 1302 4 absent absent JJ cord-028721-x6f26ahr 1302 5 or or CC cord-028721-x6f26ahr 1302 6 vanishing vanish VBG cord-028721-x6f26ahr 1302 7 testes testis NNS cord-028721-x6f26ahr 1302 8 ( ( -LRB- cord-028721-x6f26ahr 1302 9 16 16 CD cord-028721-x6f26ahr 1302 10 % % NN cord-028721-x6f26ahr 1302 11 of of IN cord-028721-x6f26ahr 1302 12 cases case NNS cord-028721-x6f26ahr 1302 13 ) ) -RRB- cord-028721-x6f26ahr 1302 14 . . . cord-028721-x6f26ahr 1303 1 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 1303 2 is be VBZ cord-028721-x6f26ahr 1303 3 part part NN cord-028721-x6f26ahr 1303 4 of of IN cord-028721-x6f26ahr 1303 5 the the DT cord-028721-x6f26ahr 1303 6 testicular testicular NNP cord-028721-x6f26ahr 1303 7 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 1303 8 syndrome syndrome NN cord-028721-x6f26ahr 1303 9 . . . cord-028721-x6f26ahr 1304 1 This this DT cord-028721-x6f26ahr 1304 2 consists consist VBZ cord-028721-x6f26ahr 1304 3 of of IN cord-028721-x6f26ahr 1304 4 abnormal abnormal JJ cord-028721-x6f26ahr 1304 5 testicular testicular JJ cord-028721-x6f26ahr 1304 6 development development NN cord-028721-x6f26ahr 1304 7 that that WDT cord-028721-x6f26ahr 1304 8 predisposes predispose VBZ cord-028721-x6f26ahr 1304 9 to to IN cord-028721-x6f26ahr 1304 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1304 11 , , , cord-028721-x6f26ahr 1304 12 hypospadias hypospadia NNS cord-028721-x6f26ahr 1304 13 , , , cord-028721-x6f26ahr 1304 14 spermatogenetic spermatogenetic NN cord-028721-x6f26ahr 1304 15 alterations alteration NNS cord-028721-x6f26ahr 1304 16 , , , cord-028721-x6f26ahr 1304 17 and and CC cord-028721-x6f26ahr 1304 18 testicular testicular JJ cord-028721-x6f26ahr 1304 19 cancer cancer NN cord-028721-x6f26ahr 1304 20 . . . cord-028721-x6f26ahr 1305 1 The the DT cord-028721-x6f26ahr 1305 2 association association NN cord-028721-x6f26ahr 1305 3 of of IN cord-028721-x6f26ahr 1305 4 these these DT cord-028721-x6f26ahr 1305 5 disorders disorder NNS cord-028721-x6f26ahr 1305 6 with with IN cord-028721-x6f26ahr 1305 7 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1305 8 has have VBZ cord-028721-x6f26ahr 1305 9 been be VBN cord-028721-x6f26ahr 1305 10 corroborated corroborate VBN cord-028721-x6f26ahr 1305 11 by by IN cord-028721-x6f26ahr 1305 12 numerous numerous JJ cord-028721-x6f26ahr 1305 13 clinical clinical JJ cord-028721-x6f26ahr 1305 14 , , , cord-028721-x6f26ahr 1305 15 epidemiological epidemiological JJ cord-028721-x6f26ahr 1305 16 and and CC cord-028721-x6f26ahr 1305 17 genetic genetic JJ cord-028721-x6f26ahr 1305 18 studies study NNS cord-028721-x6f26ahr 1305 19 . . . cord-028721-x6f26ahr 1306 1 The the DT cord-028721-x6f26ahr 1306 2 least least JJS cord-028721-x6f26ahr 1306 3 severe severe JJ cord-028721-x6f26ahr 1306 4 form form NN cord-028721-x6f26ahr 1306 5 of of IN cord-028721-x6f26ahr 1306 6 this this DT cord-028721-x6f26ahr 1306 7 syndrome syndrome NN cord-028721-x6f26ahr 1306 8 is be VBZ cord-028721-x6f26ahr 1306 9 a a DT cord-028721-x6f26ahr 1306 10 defect defect NN cord-028721-x6f26ahr 1306 11 in in IN cord-028721-x6f26ahr 1306 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1306 13 ; ; : cord-028721-x6f26ahr 1306 14 the the DT cord-028721-x6f26ahr 1306 15 most most RBS cord-028721-x6f26ahr 1306 16 severe severe JJ cord-028721-x6f26ahr 1306 17 is be VBZ cord-028721-x6f26ahr 1306 18 testicular testicular JJ cord-028721-x6f26ahr 1306 19 cancer cancer NN cord-028721-x6f26ahr 1306 20 . . . cord-028721-x6f26ahr 1307 1 A a DT cord-028721-x6f26ahr 1307 2 constellation constellation NN cord-028721-x6f26ahr 1307 3 of of IN cord-028721-x6f26ahr 1307 4 histologic histologic JJ cord-028721-x6f26ahr 1307 5 lesions lesion NNS cord-028721-x6f26ahr 1307 6 is be VBZ cord-028721-x6f26ahr 1307 7 common common JJ cord-028721-x6f26ahr 1307 8 in in IN cord-028721-x6f26ahr 1307 9 the the DT cord-028721-x6f26ahr 1307 10 testes testis NNS cord-028721-x6f26ahr 1307 11 of of IN cord-028721-x6f26ahr 1307 12 men man NNS cord-028721-x6f26ahr 1307 13 with with IN cord-028721-x6f26ahr 1307 14 testicular testicular JJ cord-028721-x6f26ahr 1307 15 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1307 16 ; ; : cord-028721-x6f26ahr 1307 17 these these DT cord-028721-x6f26ahr 1307 18 lesions lesion NNS cord-028721-x6f26ahr 1307 19 include include VBP cord-028721-x6f26ahr 1307 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 1307 21 cellonly cellonly NN cord-028721-x6f26ahr 1307 22 pattern pattern NN cord-028721-x6f26ahr 1307 23 , , , cord-028721-x6f26ahr 1307 24 mixed mixed JJ cord-028721-x6f26ahr 1307 25 atrophy atrophy NN cord-028721-x6f26ahr 1307 26 , , , cord-028721-x6f26ahr 1307 27 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1307 28 tubules tubule NNS cord-028721-x6f26ahr 1307 29 ( ( -LRB- cord-028721-x6f26ahr 1307 30 Sertoli sertoli JJ cord-028721-x6f26ahr 1307 31 cell cell NN cord-028721-x6f26ahr 1307 32 nodules nodule NNS cord-028721-x6f26ahr 1307 33 ) ) -RRB- cord-028721-x6f26ahr 1307 34 , , , cord-028721-x6f26ahr 1307 35 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1307 36 , , , cord-028721-x6f26ahr 1307 37 malformed malformed JJ cord-028721-x6f26ahr 1307 38 tubules tubule NNS cord-028721-x6f26ahr 1307 39 , , , cord-028721-x6f26ahr 1307 40 granular granular JJ cord-028721-x6f26ahr 1307 41 changes change NNS cord-028721-x6f26ahr 1307 42 in in IN cord-028721-x6f26ahr 1307 43 Sertoli Sertoli NNP cord-028721-x6f26ahr 1307 44 cells cell NNS cord-028721-x6f26ahr 1307 45 , , , cord-028721-x6f26ahr 1307 46 nodular nodular JJ cord-028721-x6f26ahr 1307 47 Leydig Leydig NNP cord-028721-x6f26ahr 1307 48 cell cell NN cord-028721-x6f26ahr 1307 49 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1307 50 , , , cord-028721-x6f26ahr 1307 51 and and CC cord-028721-x6f26ahr 1307 52 intratubular intratubular JJ cord-028721-x6f26ahr 1307 53 germ germ NN cord-028721-x6f26ahr 1307 54 cell cell NN cord-028721-x6f26ahr 1307 55 neoplasia neoplasia NN cord-028721-x6f26ahr 1307 56 . . . cord-028721-x6f26ahr 1308 1 It -PRON- PRP cord-028721-x6f26ahr 1308 2 is be VBZ cord-028721-x6f26ahr 1308 3 assumed assume VBN cord-028721-x6f26ahr 1308 4 that that IN cord-028721-x6f26ahr 1308 5 there there EX cord-028721-x6f26ahr 1308 6 is be VBZ cord-028721-x6f26ahr 1308 7 a a DT cord-028721-x6f26ahr 1308 8 prenatal prenatal JJ cord-028721-x6f26ahr 1308 9 development development NN cord-028721-x6f26ahr 1308 10 of of IN cord-028721-x6f26ahr 1308 11 the the DT cord-028721-x6f26ahr 1308 12 lesions lesion NNS cord-028721-x6f26ahr 1308 13 as as IN cord-028721-x6f26ahr 1308 14 a a DT cord-028721-x6f26ahr 1308 15 result result NN cord-028721-x6f26ahr 1308 16 of of IN cord-028721-x6f26ahr 1308 17 several several JJ cord-028721-x6f26ahr 1308 18 genetic genetic JJ cord-028721-x6f26ahr 1308 19 , , , cord-028721-x6f26ahr 1308 20 environmental environmental JJ cord-028721-x6f26ahr 1308 21 , , , cord-028721-x6f26ahr 1308 22 or or CC cord-028721-x6f26ahr 1308 23 endocrine endocrine JJ cord-028721-x6f26ahr 1308 24 disruptor disruptor NN cord-028721-x6f26ahr 1308 25 factors factor NNS cord-028721-x6f26ahr 1308 26 that that WDT cord-028721-x6f26ahr 1308 27 would would MD cord-028721-x6f26ahr 1308 28 interfere interfere VB cord-028721-x6f26ahr 1308 29 with with IN cord-028721-x6f26ahr 1308 30 the the DT cord-028721-x6f26ahr 1308 31 estrogen estrogen NN cord-028721-x6f26ahr 1308 32 / / SYM cord-028721-x6f26ahr 1308 33 androgen androgen NN cord-028721-x6f26ahr 1308 34 ratio ratio NN cord-028721-x6f26ahr 1308 35 . . . cord-028721-x6f26ahr 1309 1 [ [ -LRB- cord-028721-x6f26ahr 1309 2 553 553 CD cord-028721-x6f26ahr 1309 3 ] ] -RRB- cord-028721-x6f26ahr 1309 4 [ [ -LRB- cord-028721-x6f26ahr 1309 5 554 554 CD cord-028721-x6f26ahr 1309 6 ] ] -RRB- cord-028721-x6f26ahr 1310 1 [ [ -LRB- cord-028721-x6f26ahr 1310 2 555 555 CD cord-028721-x6f26ahr 1310 3 ] ] -RRB- cord-028721-x6f26ahr 1311 1 [ [ -LRB- cord-028721-x6f26ahr 1311 2 556 556 CD cord-028721-x6f26ahr 1311 3 ] ] -RRB- cord-028721-x6f26ahr 1311 4 _SP cord-028721-x6f26ahr 1312 1 The the DT cord-028721-x6f26ahr 1312 2 main main JJ cord-028721-x6f26ahr 1312 3 complications complication NNS cord-028721-x6f26ahr 1312 4 of of IN cord-028721-x6f26ahr 1312 5 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1312 6 are be VBP cord-028721-x6f26ahr 1312 7 testicular testicular JJ cord-028721-x6f26ahr 1312 8 cancer cancer NN cord-028721-x6f26ahr 1312 9 , , , cord-028721-x6f26ahr 1312 10 infertility infertility NN cord-028721-x6f26ahr 1312 11 , , , cord-028721-x6f26ahr 1312 12 testicular testicular NN cord-028721-x6f26ahr 1312 13 torsion torsion NN cord-028721-x6f26ahr 1312 14 , , , cord-028721-x6f26ahr 1312 15 and and CC cord-028721-x6f26ahr 1312 16 psychological psychological JJ cord-028721-x6f26ahr 1312 17 problems problem NNS cord-028721-x6f26ahr 1312 18 . . . cord-028721-x6f26ahr 1313 1 Approximately approximately RB cord-028721-x6f26ahr 1313 2 0.8 0.8 CD cord-028721-x6f26ahr 1313 3 % % NN cord-028721-x6f26ahr 1313 4 of of IN cord-028721-x6f26ahr 1313 5 1-year 1-year CD cord-028721-x6f26ahr 1313 6 - - HYPH cord-028721-x6f26ahr 1313 7 old old JJ cord-028721-x6f26ahr 1313 8 males male NNS cord-028721-x6f26ahr 1313 9 have have VBP cord-028721-x6f26ahr 1313 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1313 11 , , , cord-028721-x6f26ahr 1313 12 and and CC cord-028721-x6f26ahr 1313 13 about about RB cord-028721-x6f26ahr 1313 14 10 10 CD cord-028721-x6f26ahr 1313 15 % % NN cord-028721-x6f26ahr 1313 16 of of IN cord-028721-x6f26ahr 1313 17 testicular testicular JJ cord-028721-x6f26ahr 1313 18 cancer cancer NN cord-028721-x6f26ahr 1313 19 patients patient NNS cord-028721-x6f26ahr 1313 20 had have VBD cord-028721-x6f26ahr 1313 21 cryptorchidism cryptorchidism NNS cord-028721-x6f26ahr 1313 22 . . . cord-028721-x6f26ahr 1314 1 The the DT cord-028721-x6f26ahr 1314 2 risk risk NN cord-028721-x6f26ahr 1314 3 of of IN cord-028721-x6f26ahr 1314 4 testicular testicular JJ cord-028721-x6f26ahr 1314 5 cancer cancer NN cord-028721-x6f26ahr 1314 6 in in IN cord-028721-x6f26ahr 1314 7 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1314 8 males male NNS cord-028721-x6f26ahr 1314 9 is be VBZ cord-028721-x6f26ahr 1314 10 four four CD cord-028721-x6f26ahr 1314 11 to10 to10 NN cord-028721-x6f26ahr 1314 12 times time NNS cord-028721-x6f26ahr 1314 13 higher high JJR cord-028721-x6f26ahr 1314 14 than than IN cord-028721-x6f26ahr 1314 15 that that DT cord-028721-x6f26ahr 1314 16 of of IN cord-028721-x6f26ahr 1314 17 the the DT cord-028721-x6f26ahr 1314 18 general general JJ cord-028721-x6f26ahr 1314 19 population population NN cord-028721-x6f26ahr 1314 20 . . . cord-028721-x6f26ahr 1315 1 Testes testis NNS cord-028721-x6f26ahr 1315 2 with with IN cord-028721-x6f26ahr 1315 3 elevated elevated JJ cord-028721-x6f26ahr 1315 4 number number NN cord-028721-x6f26ahr 1315 5 of of IN cord-028721-x6f26ahr 1315 6 multinucleated multinucleated JJ cord-028721-x6f26ahr 1315 7 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1315 8 seem seem VBP cord-028721-x6f26ahr 1315 9 to to TO cord-028721-x6f26ahr 1315 10 have have VB cord-028721-x6f26ahr 1315 11 a a DT cord-028721-x6f26ahr 1315 12 higher high JJR cord-028721-x6f26ahr 1315 13 risk risk NN cord-028721-x6f26ahr 1315 14 of of IN cord-028721-x6f26ahr 1315 15 cancer cancer NN cord-028721-x6f26ahr 1315 16 and and CC cord-028721-x6f26ahr 1315 17 adulthood adulthood NN cord-028721-x6f26ahr 1315 18 . . . cord-028721-x6f26ahr 1316 1 557 557 CD cord-028721-x6f26ahr 1317 1 About about RB cord-028721-x6f26ahr 1317 2 5 5 CD cord-028721-x6f26ahr 1317 3 % % NN cord-028721-x6f26ahr 1317 4 of of IN cord-028721-x6f26ahr 1317 5 biopsies biopsy NNS cord-028721-x6f26ahr 1317 6 in in IN cord-028721-x6f26ahr 1317 7 children child NNS cord-028721-x6f26ahr 1317 8 contain contain VBP cord-028721-x6f26ahr 1317 9 cells cell NNS cord-028721-x6f26ahr 1317 10 similar similar JJ cord-028721-x6f26ahr 1317 11 to to IN cord-028721-x6f26ahr 1317 12 those those DT cord-028721-x6f26ahr 1317 13 seen see VBN cord-028721-x6f26ahr 1317 14 in in IN cord-028721-x6f26ahr 1317 15 undifferentiated undifferentiated JJ cord-028721-x6f26ahr 1317 16 intratubular intratubular JJ cord-028721-x6f26ahr 1317 17 germ germ NN cord-028721-x6f26ahr 1317 18 cell cell NN cord-028721-x6f26ahr 1317 19 neoplasia neoplasia NN cord-028721-x6f26ahr 1317 20 , , , cord-028721-x6f26ahr 1317 21 and and CC cord-028721-x6f26ahr 1317 22 these these DT cord-028721-x6f26ahr 1317 23 cells cell NNS cord-028721-x6f26ahr 1317 24 may may MD cord-028721-x6f26ahr 1317 25 evolve evolve VB cord-028721-x6f26ahr 1317 26 toward toward IN cord-028721-x6f26ahr 1317 27 germ germ NN cord-028721-x6f26ahr 1317 28 cell cell NN cord-028721-x6f26ahr 1317 29 tumor tumor NN cord-028721-x6f26ahr 1317 30 ( ( -LRB- cord-028721-x6f26ahr 1317 31 Fig Fig NNP cord-028721-x6f26ahr 1317 32 . . . cord-028721-x6f26ahr 1317 33 _SP cord-028721-x6f26ahr 1318 1 12 12 CD cord-028721-x6f26ahr 1318 2 - - SYM cord-028721-x6f26ahr 1318 3 57 57 CD cord-028721-x6f26ahr 1318 4 ) ) -RRB- cord-028721-x6f26ahr 1318 5 . . . cord-028721-x6f26ahr 1319 1 558 558 CD cord-028721-x6f26ahr 1320 1 The the DT cord-028721-x6f26ahr 1320 2 most most RBS cord-028721-x6f26ahr 1320 3 frequent frequent JJ cord-028721-x6f26ahr 1320 4 tumor tumor NN cord-028721-x6f26ahr 1320 5 in in IN cord-028721-x6f26ahr 1320 6 undescended undescended JJ cord-028721-x6f26ahr 1320 7 testes testis NNS cord-028721-x6f26ahr 1320 8 is be VBZ cord-028721-x6f26ahr 1320 9 seminoma seminoma NN cord-028721-x6f26ahr 1320 10 . . . cord-028721-x6f26ahr 1321 1 559 559 CD cord-028721-x6f26ahr 1321 2 , , , cord-028721-x6f26ahr 1321 3 560 560 CD cord-028721-x6f26ahr 1321 4 Regardless regardless RB cord-028721-x6f26ahr 1321 5 of of IN cord-028721-x6f26ahr 1321 6 timing timing NN cord-028721-x6f26ahr 1321 7 , , , cord-028721-x6f26ahr 1321 8 orchidopexy orchidopexy NN cord-028721-x6f26ahr 1321 9 does do VBZ cord-028721-x6f26ahr 1321 10 not not RB cord-028721-x6f26ahr 1321 11 reduce reduce VB cord-028721-x6f26ahr 1321 12 the the DT cord-028721-x6f26ahr 1321 13 risk risk NN cord-028721-x6f26ahr 1321 14 of of IN cord-028721-x6f26ahr 1321 15 cancer cancer NN cord-028721-x6f26ahr 1321 16 , , , cord-028721-x6f26ahr 1321 17 although although IN cord-028721-x6f26ahr 1321 18 it -PRON- PRP cord-028721-x6f26ahr 1321 19 facilitates facilitate VBZ cord-028721-x6f26ahr 1321 20 early early JJ cord-028721-x6f26ahr 1321 21 detection detection NN cord-028721-x6f26ahr 1321 22 as as IN cord-028721-x6f26ahr 1321 23 the the DT cord-028721-x6f26ahr 1321 24 intrascrotal intrascrotal JJ cord-028721-x6f26ahr 1321 25 testis testis NN cord-028721-x6f26ahr 1321 26 is be VBZ cord-028721-x6f26ahr 1321 27 palpable palpable JJ cord-028721-x6f26ahr 1321 28 . . . cord-028721-x6f26ahr 1322 1 One one CD cord-028721-x6f26ahr 1322 2 in in IN cord-028721-x6f26ahr 1322 3 fi fi NNP cord-028721-x6f26ahr 1322 4 ve ve NNP cord-028721-x6f26ahr 1322 5 testicular testicular JJ cord-028721-x6f26ahr 1322 6 tumors tumor NNS cord-028721-x6f26ahr 1322 7 arises arise VBZ cord-028721-x6f26ahr 1322 8 in in IN cord-028721-x6f26ahr 1322 9 properly properly RB cord-028721-x6f26ahr 1322 10 descended descend VBN cord-028721-x6f26ahr 1322 11 testes testis NNS cord-028721-x6f26ahr 1322 12 contralateral contralateral JJ cord-028721-x6f26ahr 1322 13 to to IN cord-028721-x6f26ahr 1322 14 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1322 15 testes testis NNS cord-028721-x6f26ahr 1322 16 , , , cord-028721-x6f26ahr 1322 17 suggesting suggest VBG cord-028721-x6f26ahr 1322 18 that that IN cord-028721-x6f26ahr 1322 19 there there EX cord-028721-x6f26ahr 1322 20 is be VBZ cord-028721-x6f26ahr 1322 21 a a DT cord-028721-x6f26ahr 1322 22 primary primary JJ cord-028721-x6f26ahr 1322 23 bilateral bilateral JJ cord-028721-x6f26ahr 1322 24 testicular testicular JJ cord-028721-x6f26ahr 1322 25 anomaly anomaly NN cord-028721-x6f26ahr 1322 26 in in IN cord-028721-x6f26ahr 1322 27 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1322 28 . . . cord-028721-x6f26ahr 1323 1 Intra intra JJ cord-028721-x6f26ahr 1323 2 - - JJ cord-028721-x6f26ahr 1323 3 abdominal abdominal JJ cord-028721-x6f26ahr 1323 4 testes testis NNS cord-028721-x6f26ahr 1323 5 also also RB cord-028721-x6f26ahr 1323 6 have have VBP cord-028721-x6f26ahr 1323 7 a a DT cord-028721-x6f26ahr 1323 8 higher high JJR cord-028721-x6f26ahr 1323 9 incidence incidence NN cord-028721-x6f26ahr 1323 10 of of IN cord-028721-x6f26ahr 1323 11 tumors tumor NNS cord-028721-x6f26ahr 1323 12 . . . cord-028721-x6f26ahr 1324 1 560 560 CD cord-028721-x6f26ahr 1324 2 Infertility Infertility NNP cord-028721-x6f26ahr 1324 3 Infertility Infertility NNP cord-028721-x6f26ahr 1324 4 is be VBZ cord-028721-x6f26ahr 1324 5 the the DT cord-028721-x6f26ahr 1324 6 most most RBS cord-028721-x6f26ahr 1324 7 frequent frequent JJ cord-028721-x6f26ahr 1324 8 problem problem NN cord-028721-x6f26ahr 1324 9 caused cause VBN cord-028721-x6f26ahr 1324 10 by by IN cord-028721-x6f26ahr 1324 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1324 12 . . . cord-028721-x6f26ahr 1325 1 In in IN cord-028721-x6f26ahr 1325 2 a a DT cord-028721-x6f26ahr 1325 3 series series NN cord-028721-x6f26ahr 1325 4 of of IN cord-028721-x6f26ahr 1325 5 patients patient NNS cord-028721-x6f26ahr 1325 6 with with IN cord-028721-x6f26ahr 1325 7 infertility infertility NN cord-028721-x6f26ahr 1325 8 , , , cord-028721-x6f26ahr 1325 9 nearly nearly RB cord-028721-x6f26ahr 1325 10 9 9 CD cord-028721-x6f26ahr 1325 11 % % NN cord-028721-x6f26ahr 1325 12 had have VBD cord-028721-x6f26ahr 1325 13 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1325 14 . . . cord-028721-x6f26ahr 1326 1 561 561 CD cord-028721-x6f26ahr 1326 2 Infertility Infertility NNP cord-028721-x6f26ahr 1326 3 is be VBZ cord-028721-x6f26ahr 1326 4 infl infl NN cord-028721-x6f26ahr 1326 5 uenced uence VBN cord-028721-x6f26ahr 1326 6 by by IN cord-028721-x6f26ahr 1326 7 several several JJ cord-028721-x6f26ahr 1326 8 factors factor NNS cord-028721-x6f26ahr 1326 9 , , , cord-028721-x6f26ahr 1326 10 including include VBG cord-028721-x6f26ahr 1326 11 bilaterality bilaterality NN cord-028721-x6f26ahr 1326 12 , , , cord-028721-x6f26ahr 1326 13 number number NN cord-028721-x6f26ahr 1326 14 of of IN cord-028721-x6f26ahr 1326 15 germ germ NN cord-028721-x6f26ahr 1326 16 cells cell NNS cord-028721-x6f26ahr 1326 17 , , , cord-028721-x6f26ahr 1326 18 location location NN cord-028721-x6f26ahr 1326 19 and and CC cord-028721-x6f26ahr 1326 20 size size NN cord-028721-x6f26ahr 1326 21 of of IN cord-028721-x6f26ahr 1326 22 the the DT cord-028721-x6f26ahr 1326 23 testis testis NN cord-028721-x6f26ahr 1326 24 , , , cord-028721-x6f26ahr 1326 25 and and CC cord-028721-x6f26ahr 1326 26 age age NN cord-028721-x6f26ahr 1326 27 at at IN cord-028721-x6f26ahr 1326 28 time time NN cord-028721-x6f26ahr 1326 29 of of IN cord-028721-x6f26ahr 1326 30 orchidopexy orchidopexy NN cord-028721-x6f26ahr 1326 31 . . . cord-028721-x6f26ahr 1327 1 The the DT cord-028721-x6f26ahr 1327 2 most most RBS cord-028721-x6f26ahr 1327 3 important important JJ cord-028721-x6f26ahr 1327 4 risk risk NN cord-028721-x6f26ahr 1327 5 factors factor NNS cord-028721-x6f26ahr 1327 6 are be VBP cord-028721-x6f26ahr 1327 7 bilaterality bilaterality NN cord-028721-x6f26ahr 1327 8 and and CC cord-028721-x6f26ahr 1327 9 germ germ NN cord-028721-x6f26ahr 1327 10 cell cell NN cord-028721-x6f26ahr 1327 11 number number NN cord-028721-x6f26ahr 1327 12 . . . cord-028721-x6f26ahr 1328 1 Only only RB cord-028721-x6f26ahr 1328 2 16 16 CD cord-028721-x6f26ahr 1328 3 % % NN cord-028721-x6f26ahr 1328 4 562 562 CD cord-028721-x6f26ahr 1328 5 to to TO cord-028721-x6f26ahr 1328 6 25 25 CD cord-028721-x6f26ahr 1328 7 % % NN cord-028721-x6f26ahr 1328 8 563 563 CD cord-028721-x6f26ahr 1328 9 of of IN cord-028721-x6f26ahr 1328 10 men man NNS cord-028721-x6f26ahr 1328 11 with with IN cord-028721-x6f26ahr 1328 12 bilateral bilateral JJ cord-028721-x6f26ahr 1328 13 cryptorchidism cryptorchidism NNS cord-028721-x6f26ahr 1328 14 have have VBP cord-028721-x6f26ahr 1328 15 normal normal JJ cord-028721-x6f26ahr 1328 16 sperm sperm NN cord-028721-x6f26ahr 1328 17 counts count NNS cord-028721-x6f26ahr 1328 18 ( ( -LRB- cord-028721-x6f26ahr 1328 19 20 20 CD cord-028721-x6f26ahr 1328 20 million million CD cord-028721-x6f26ahr 1328 21 / / SYM cord-028721-x6f26ahr 1328 22 mL ml NN cord-028721-x6f26ahr 1328 23 or or CC cord-028721-x6f26ahr 1328 24 more more JJR cord-028721-x6f26ahr 1328 25 ) ) -RRB- cord-028721-x6f26ahr 1328 26 . . . cord-028721-x6f26ahr 1329 1 The the DT cord-028721-x6f26ahr 1329 2 highest high JJS cord-028721-x6f26ahr 1329 3 sperm sperm NN cord-028721-x6f26ahr 1329 4 counts count NNS cord-028721-x6f26ahr 1329 5 occur occur VBP cord-028721-x6f26ahr 1329 6 with with IN cord-028721-x6f26ahr 1329 7 testes testis NNS cord-028721-x6f26ahr 1329 8 in in IN cord-028721-x6f26ahr 1329 9 the the DT cord-028721-x6f26ahr 1329 10 superfi superfi NNS cord-028721-x6f26ahr 1329 11 cial cial NNP cord-028721-x6f26ahr 1329 12 inguinal inguinal JJ cord-028721-x6f26ahr 1329 13 pouch pouch NN cord-028721-x6f26ahr 1329 14 . . . cord-028721-x6f26ahr 1330 1 Patients patient NNS cord-028721-x6f26ahr 1330 2 with with IN cord-028721-x6f26ahr 1330 3 bilaterally bilaterally RB cord-028721-x6f26ahr 1330 4 impalpable impalpable JJ cord-028721-x6f26ahr 1330 5 testes testis NNS cord-028721-x6f26ahr 1330 6 are be VBP cord-028721-x6f26ahr 1330 7 usually usually RB cord-028721-x6f26ahr 1330 8 azoospermic azoospermic JJ cord-028721-x6f26ahr 1330 9 . . . cord-028721-x6f26ahr 1331 1 563 563 CD cord-028721-x6f26ahr 1331 2 Fertility fertility NN cord-028721-x6f26ahr 1331 3 rates rate NNS cord-028721-x6f26ahr 1331 4 in in IN cord-028721-x6f26ahr 1331 5 unilateral unilateral JJ cord-028721-x6f26ahr 1331 6 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1331 7 vary vary VBP cord-028721-x6f26ahr 1331 8 from from IN cord-028721-x6f26ahr 1331 9 25 25 CD cord-028721-x6f26ahr 1331 10 % % NN cord-028721-x6f26ahr 1331 11 to to IN cord-028721-x6f26ahr 1331 12 81 81 CD cord-028721-x6f26ahr 1331 13 % % NN cord-028721-x6f26ahr 1331 14 . . . cord-028721-x6f26ahr 1332 1 564 564 CD cord-028721-x6f26ahr 1333 1 The the DT cord-028721-x6f26ahr 1333 2 number number NN cord-028721-x6f26ahr 1333 3 of of IN cord-028721-x6f26ahr 1333 4 germ germ NN cord-028721-x6f26ahr 1333 5 cells cell NNS cord-028721-x6f26ahr 1333 6 per per IN cord-028721-x6f26ahr 1333 7 cross cross JJ cord-028721-x6f26ahr 1333 8 - - JJ cord-028721-x6f26ahr 1333 9 sectioned sectioned JJ cord-028721-x6f26ahr 1333 10 tubule tubule NN cord-028721-x6f26ahr 1333 11 is be VBZ cord-028721-x6f26ahr 1333 12 the the DT cord-028721-x6f26ahr 1333 13 most most RBS cord-028721-x6f26ahr 1333 14 important important JJ cord-028721-x6f26ahr 1333 15 prognostic prognostic JJ cord-028721-x6f26ahr 1333 16 factor factor NN cord-028721-x6f26ahr 1333 17 . . . cord-028721-x6f26ahr 1334 1 Patients patient NNS cord-028721-x6f26ahr 1334 2 with with IN cord-028721-x6f26ahr 1334 3 no no DT cord-028721-x6f26ahr 1334 4 increase increase NN cord-028721-x6f26ahr 1334 5 in in IN cord-028721-x6f26ahr 1334 6 inhibin inhibin NNP cord-028721-x6f26ahr 1334 7 B B NNP cord-028721-x6f26ahr 1334 8 during during IN cord-028721-x6f26ahr 1334 9 the the DT cord-028721-x6f26ahr 1334 10 postoperative postoperative JJ cord-028721-x6f26ahr 1334 11 period period NN cord-028721-x6f26ahr 1334 12 usually usually RB cord-028721-x6f26ahr 1334 13 have have VBP cord-028721-x6f26ahr 1334 14 a a DT cord-028721-x6f26ahr 1334 15 low low JJ cord-028721-x6f26ahr 1334 16 number number NN cord-028721-x6f26ahr 1334 17 of of IN cord-028721-x6f26ahr 1334 18 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1334 19 per per IN cord-028721-x6f26ahr 1334 20 cross cross JJ cord-028721-x6f26ahr 1334 21 - - JJ cord-028721-x6f26ahr 1334 22 sectioned section VBN cord-028721-x6f26ahr 1334 23 tubule tubule NN cord-028721-x6f26ahr 1334 24 and and CC cord-028721-x6f26ahr 1334 25 a a DT cord-028721-x6f26ahr 1334 26 low low JJ cord-028721-x6f26ahr 1334 27 tubular tubular JJ cord-028721-x6f26ahr 1334 28 fertility fertility NN cord-028721-x6f26ahr 1334 29 index index NN cord-028721-x6f26ahr 1334 30 . . . cord-028721-x6f26ahr 1335 1 In in IN cord-028721-x6f26ahr 1335 2 unilateral unilateral JJ cord-028721-x6f26ahr 1335 3 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1335 4 , , , cord-028721-x6f26ahr 1335 5 fertility fertility NN cord-028721-x6f26ahr 1335 6 depends depend VBZ cord-028721-x6f26ahr 1335 7 on on IN cord-028721-x6f26ahr 1335 8 the the DT cord-028721-x6f26ahr 1335 9 number number NN cord-028721-x6f26ahr 1335 10 of of IN cord-028721-x6f26ahr 1335 11 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1335 12 in in IN cord-028721-x6f26ahr 1335 13 the the DT cord-028721-x6f26ahr 1335 14 contralateral contralateral JJ cord-028721-x6f26ahr 1335 15 testis testis NN cord-028721-x6f26ahr 1335 16 . . . cord-028721-x6f26ahr 1336 1 However however RB cord-028721-x6f26ahr 1336 2 , , , cord-028721-x6f26ahr 1336 3 if if IN cord-028721-x6f26ahr 1336 4 the the DT cord-028721-x6f26ahr 1336 5 number number NN cord-028721-x6f26ahr 1336 6 of of IN cord-028721-x6f26ahr 1336 7 germ germ NN cord-028721-x6f26ahr 1336 8 cells cell NNS cord-028721-x6f26ahr 1336 9 per per IN cord-028721-x6f26ahr 1336 10 cross cross JJ cord-028721-x6f26ahr 1336 11 - - JJ cord-028721-x6f26ahr 1336 12 sectioned sectioned JJ cord-028721-x6f26ahr 1336 13 tubule tubule NN cord-028721-x6f26ahr 1336 14 in in IN cord-028721-x6f26ahr 1336 15 the the DT cord-028721-x6f26ahr 1336 16 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1336 17 testis testis NN cord-028721-x6f26ahr 1336 18 is be VBZ cord-028721-x6f26ahr 1336 19 lower low JJR cord-028721-x6f26ahr 1336 20 than than IN cord-028721-x6f26ahr 1336 21 1 1 CD cord-028721-x6f26ahr 1336 22 % % NN cord-028721-x6f26ahr 1336 23 of of IN cord-028721-x6f26ahr 1336 24 normal normal JJ cord-028721-x6f26ahr 1336 25 , , , cord-028721-x6f26ahr 1336 26 the the DT cord-028721-x6f26ahr 1336 27 risk risk NN cord-028721-x6f26ahr 1336 28 of of IN cord-028721-x6f26ahr 1336 29 infertility infertility NN cord-028721-x6f26ahr 1336 30 is be VBZ cord-028721-x6f26ahr 1336 31 33 33 CD cord-028721-x6f26ahr 1336 32 % % NN cord-028721-x6f26ahr 1336 33 . . . cord-028721-x6f26ahr 1337 1 In in IN cord-028721-x6f26ahr 1337 2 bilateral bilateral JJ cord-028721-x6f26ahr 1337 3 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1337 4 the the DT cord-028721-x6f26ahr 1337 5 risk risk NN cord-028721-x6f26ahr 1337 6 of of IN cord-028721-x6f26ahr 1337 7 infertility infertility NN cord-028721-x6f26ahr 1337 8 rises rise VBZ cord-028721-x6f26ahr 1337 9 from from IN cord-028721-x6f26ahr 1337 10 75 75 CD cord-028721-x6f26ahr 1337 11 % % NN cord-028721-x6f26ahr 1337 12 to to TO cord-028721-x6f26ahr 1337 13 100 100 CD cord-028721-x6f26ahr 1337 14 % % NN cord-028721-x6f26ahr 1337 15 when when WRB cord-028721-x6f26ahr 1337 16 one one CD cord-028721-x6f26ahr 1337 17 or or CC cord-028721-x6f26ahr 1337 18 both both DT cord-028721-x6f26ahr 1337 19 testes testis NNS cord-028721-x6f26ahr 1337 20 have have VBP cord-028721-x6f26ahr 1337 21 less less JJR cord-028721-x6f26ahr 1337 22 than than IN cord-028721-x6f26ahr 1337 23 1 1 CD cord-028721-x6f26ahr 1337 24 % % NN cord-028721-x6f26ahr 1337 25 of of IN cord-028721-x6f26ahr 1337 26 germ germ NN cord-028721-x6f26ahr 1337 27 cells cell NNS cord-028721-x6f26ahr 1337 28 per per IN cord-028721-x6f26ahr 1337 29 cross cross JJ cord-028721-x6f26ahr 1337 30 - - JJ cord-028721-x6f26ahr 1337 31 sectioned section VBN cord-028721-x6f26ahr 1337 32 tubule tubule NN cord-028721-x6f26ahr 1337 33 . . . cord-028721-x6f26ahr 1338 1 Neither neither CC cord-028721-x6f26ahr 1338 2 the the DT cord-028721-x6f26ahr 1338 3 preoperative preoperative JJ cord-028721-x6f26ahr 1338 4 location location NN cord-028721-x6f26ahr 1338 5 of of IN cord-028721-x6f26ahr 1338 6 the the DT cord-028721-x6f26ahr 1338 7 testis testis NN cord-028721-x6f26ahr 1338 8 in in IN cord-028721-x6f26ahr 1338 9 patients patient NNS cord-028721-x6f26ahr 1338 10 with with IN cord-028721-x6f26ahr 1338 11 unilateral unilateral JJ cord-028721-x6f26ahr 1338 12 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1338 13 nor nor CC cord-028721-x6f26ahr 1338 14 the the DT cord-028721-x6f26ahr 1338 15 small small JJ cord-028721-x6f26ahr 1338 16 size size NN cord-028721-x6f26ahr 1338 17 of of IN cord-028721-x6f26ahr 1338 18 the the DT cord-028721-x6f26ahr 1338 19 testis testis NN cord-028721-x6f26ahr 1338 20 at at IN cord-028721-x6f26ahr 1338 21 the the DT cord-028721-x6f26ahr 1338 22 time time NN cord-028721-x6f26ahr 1338 23 of of IN cord-028721-x6f26ahr 1338 24 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 1338 25 is be VBZ cord-028721-x6f26ahr 1338 26 relevant relevant JJ cord-028721-x6f26ahr 1338 27 for for IN cord-028721-x6f26ahr 1338 28 fertility fertility NN cord-028721-x6f26ahr 1338 29 . . . cord-028721-x6f26ahr 1339 1 [ [ -LRB- cord-028721-x6f26ahr 1339 2 565 565 CD cord-028721-x6f26ahr 1339 3 ] ] -RRB- cord-028721-x6f26ahr 1339 4 [ [ -LRB- cord-028721-x6f26ahr 1339 5 566 566 CD cord-028721-x6f26ahr 1339 6 ] ] -RRB- cord-028721-x6f26ahr 1340 1 [ [ -LRB- cord-028721-x6f26ahr 1340 2 567 567 CD cord-028721-x6f26ahr 1340 3 ] ] -RRB- cord-028721-x6f26ahr 1341 1 An an DT cord-028721-x6f26ahr 1341 2 important important JJ cord-028721-x6f26ahr 1341 3 fertility fertility NN cord-028721-x6f26ahr 1341 4 factor factor NN cord-028721-x6f26ahr 1341 5 is be VBZ cord-028721-x6f26ahr 1341 6 the the DT cord-028721-x6f26ahr 1341 7 permeability permeability NN cord-028721-x6f26ahr 1341 8 of of IN cord-028721-x6f26ahr 1341 9 sperm sperm NN cord-028721-x6f26ahr 1341 10 excretory excretory JJ cord-028721-x6f26ahr 1341 11 ducts duct NNS cord-028721-x6f26ahr 1341 12 . . . cord-028721-x6f26ahr 1342 1 The the DT cord-028721-x6f26ahr 1342 2 age age NN cord-028721-x6f26ahr 1342 3 at at IN cord-028721-x6f26ahr 1342 4 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 1342 5 may may MD cord-028721-x6f26ahr 1342 6 also also RB cord-028721-x6f26ahr 1342 7 infl infl VB cord-028721-x6f26ahr 1342 8 uence uence NN cord-028721-x6f26ahr 1342 9 fertility fertility NN cord-028721-x6f26ahr 1342 10 , , , cord-028721-x6f26ahr 1342 11 although although IN cord-028721-x6f26ahr 1342 12 this this DT cord-028721-x6f26ahr 1342 13 has have VBZ cord-028721-x6f26ahr 1342 14 not not RB cord-028721-x6f26ahr 1342 15 been be VBN cord-028721-x6f26ahr 1342 16 proven prove VBN cord-028721-x6f26ahr 1342 17 . . . cord-028721-x6f26ahr 1343 1 In in IN cord-028721-x6f26ahr 1343 2 patients patient NNS cord-028721-x6f26ahr 1343 3 over over IN cord-028721-x6f26ahr 1343 4 4 4 CD cord-028721-x6f26ahr 1343 5 years year NNS cord-028721-x6f26ahr 1343 6 of of IN cord-028721-x6f26ahr 1343 7 age age NN cord-028721-x6f26ahr 1343 8 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 1343 9 does do VBZ cord-028721-x6f26ahr 1343 10 not not RB cord-028721-x6f26ahr 1343 11 enhance enhance VB cord-028721-x6f26ahr 1343 12 fertility fertility NN cord-028721-x6f26ahr 1343 13 . . . cord-028721-x6f26ahr 1344 1 568 568 CD cord-028721-x6f26ahr 1344 2 , , , cord-028721-x6f26ahr 1344 3 569 569 CD cord-028721-x6f26ahr 1344 4 Benefi Benefi NNP cord-028721-x6f26ahr 1344 5 t t NN cord-028721-x6f26ahr 1344 6 of of IN cord-028721-x6f26ahr 1344 7 testicular testicular JJ cord-028721-x6f26ahr 1344 8 biopsy biopsy NN cord-028721-x6f26ahr 1344 9 in in IN cord-028721-x6f26ahr 1344 10 patients patient NNS cord-028721-x6f26ahr 1344 11 with with IN cord-028721-x6f26ahr 1344 12 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1344 13 Testicular testicular JJ cord-028721-x6f26ahr 1344 14 biopsies biopsy NNS cord-028721-x6f26ahr 1344 15 of of IN cord-028721-x6f26ahr 1344 16 infantile infantile JJ cord-028721-x6f26ahr 1344 17 testes testis NNS cord-028721-x6f26ahr 1344 18 at at IN cord-028721-x6f26ahr 1344 19 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 1344 20 are be VBP cord-028721-x6f26ahr 1344 21 useful useful JJ cord-028721-x6f26ahr 1344 22 for for IN cord-028721-x6f26ahr 1344 23 determining determine VBG cord-028721-x6f26ahr 1344 24 baseline baseline JJ cord-028721-x6f26ahr 1344 25 germ germ NN cord-028721-x6f26ahr 1344 26 cell cell NN cord-028721-x6f26ahr 1344 27 status status NN cord-028721-x6f26ahr 1344 28 and and CC cord-028721-x6f26ahr 1344 29 whether whether IN cord-028721-x6f26ahr 1344 30 surgery surgery NN cord-028721-x6f26ahr 1344 31 should should MD cord-028721-x6f26ahr 1344 32 be be VB cord-028721-x6f26ahr 1344 33 completed complete VBN cord-028721-x6f26ahr 1344 34 with with IN cord-028721-x6f26ahr 1344 35 hormonal hormonal JJ cord-028721-x6f26ahr 1344 36 treatment treatment NN cord-028721-x6f26ahr 1344 37 . . . cord-028721-x6f26ahr 1345 1 570 570 CD cord-028721-x6f26ahr 1346 1 However however RB cord-028721-x6f26ahr 1346 2 , , , cord-028721-x6f26ahr 1346 3 even even RB cord-028721-x6f26ahr 1346 4 if if IN cord-028721-x6f26ahr 1346 5 biopsy biopsy NN cord-028721-x6f26ahr 1346 6 supplies supply VBZ cord-028721-x6f26ahr 1346 7 important important JJ cord-028721-x6f26ahr 1346 8 data datum NNS cord-028721-x6f26ahr 1346 9 , , , cord-028721-x6f26ahr 1346 10 it -PRON- PRP cord-028721-x6f26ahr 1346 11 is be VBZ cord-028721-x6f26ahr 1346 12 not not RB cord-028721-x6f26ahr 1346 13 considered consider VBN cord-028721-x6f26ahr 1346 14 a a DT cord-028721-x6f26ahr 1346 15 routine routine JJ cord-028721-x6f26ahr 1346 16 procedure procedure NN cord-028721-x6f26ahr 1346 17 . . . cord-028721-x6f26ahr 1347 1 Even even RB cord-028721-x6f26ahr 1347 2 in in IN cord-028721-x6f26ahr 1347 3 the the DT cord-028721-x6f26ahr 1347 4 best good JJS cord-028721-x6f26ahr 1347 5 cases case NNS cord-028721-x6f26ahr 1347 6 when when WRB cord-028721-x6f26ahr 1347 7 the the DT cord-028721-x6f26ahr 1347 8 number number NN cord-028721-x6f26ahr 1347 9 of of IN cord-028721-x6f26ahr 1347 10 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1347 11 is be VBZ cord-028721-x6f26ahr 1347 12 nearly nearly RB cord-028721-x6f26ahr 1347 13 normal normal JJ cord-028721-x6f26ahr 1347 14 , , , cord-028721-x6f26ahr 1347 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1347 16 may may MD cord-028721-x6f26ahr 1347 17 never never RB cord-028721-x6f26ahr 1347 18 occur occur VB cord-028721-x6f26ahr 1347 19 owing owe VBG cord-028721-x6f26ahr 1347 20 to to IN cord-028721-x6f26ahr 1347 21 defi defi NNP cord-028721-x6f26ahr 1347 22 cient cient NNP cord-028721-x6f26ahr 1347 23 spermatogonium spermatogonium NNP cord-028721-x6f26ahr 1347 24 development development NN cord-028721-x6f26ahr 1347 25 during during IN cord-028721-x6f26ahr 1347 26 childhood childhood NN cord-028721-x6f26ahr 1347 27 , , , cord-028721-x6f26ahr 1347 28 failure failure NN cord-028721-x6f26ahr 1347 29 of of IN cord-028721-x6f26ahr 1347 30 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1347 31 at at IN cord-028721-x6f26ahr 1347 32 puberty puberty NN cord-028721-x6f26ahr 1347 33 , , , cord-028721-x6f26ahr 1347 34 and and CC cord-028721-x6f26ahr 1347 35 , , , cord-028721-x6f26ahr 1347 36 if if IN cord-028721-x6f26ahr 1347 37 complete complete JJ cord-028721-x6f26ahr 1347 38 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1347 39 occurs occur VBZ cord-028721-x6f26ahr 1347 40 , , , cord-028721-x6f26ahr 1347 41 this this DT cord-028721-x6f26ahr 1347 42 might may MD cord-028721-x6f26ahr 1347 43 be be VB cord-028721-x6f26ahr 1347 44 associated associate VBN cord-028721-x6f26ahr 1347 45 with with IN cord-028721-x6f26ahr 1347 46 obstruction obstruction NN cord-028721-x6f26ahr 1347 47 of of IN cord-028721-x6f26ahr 1347 48 sperm sperm NN cord-028721-x6f26ahr 1347 49 excretory excretory JJ cord-028721-x6f26ahr 1347 50 ducts duct NNS cord-028721-x6f26ahr 1347 51 . . . cord-028721-x6f26ahr 1348 1 In in IN cord-028721-x6f26ahr 1348 2 childhood childhood NN cord-028721-x6f26ahr 1348 3 , , , cord-028721-x6f26ahr 1348 4 the the DT cord-028721-x6f26ahr 1348 5 chance chance NN cord-028721-x6f26ahr 1348 6 of of IN cord-028721-x6f26ahr 1348 7 a a DT cord-028721-x6f26ahr 1348 8 biopsy biopsy NN cord-028721-x6f26ahr 1348 9 fi fi NN cord-028721-x6f26ahr 1348 10 nding nde VBG cord-028721-x6f26ahr 1348 11 an an DT cord-028721-x6f26ahr 1348 12 occult occult JJ cord-028721-x6f26ahr 1348 13 cancer cancer NN cord-028721-x6f26ahr 1348 14 or or CC cord-028721-x6f26ahr 1348 15 precancer precancer NN cord-028721-x6f26ahr 1348 16 is be VBZ cord-028721-x6f26ahr 1348 17 low low JJ cord-028721-x6f26ahr 1348 18 because because IN cord-028721-x6f26ahr 1348 19 intratubular intratubular JJ cord-028721-x6f26ahr 1348 20 germ germ NN cord-028721-x6f26ahr 1348 21 cell cell NN cord-028721-x6f26ahr 1348 22 neoplasia neoplasia NN cord-028721-x6f26ahr 1348 23 is be VBZ cord-028721-x6f26ahr 1348 24 not not RB cord-028721-x6f26ahr 1348 25 diffusely diffusely RB cord-028721-x6f26ahr 1348 26 distributed distribute VBN cord-028721-x6f26ahr 1348 27 throughout throughout IN cord-028721-x6f26ahr 1348 28 the the DT cord-028721-x6f26ahr 1348 29 testis testis NN cord-028721-x6f26ahr 1348 30 . . . cord-028721-x6f26ahr 1349 1 Testicular testicular JJ cord-028721-x6f26ahr 1349 2 biopsy biopsy NN cord-028721-x6f26ahr 1349 3 is be VBZ cord-028721-x6f26ahr 1349 4 recommended recommend VBN cord-028721-x6f26ahr 1349 5 in in IN cord-028721-x6f26ahr 1349 6 patients patient NNS cord-028721-x6f26ahr 1349 7 with with IN cord-028721-x6f26ahr 1349 8 intra intra JJ cord-028721-x6f26ahr 1349 9 - - JJ cord-028721-x6f26ahr 1349 10 abdominal abdominal JJ cord-028721-x6f26ahr 1349 11 testes testis NNS cord-028721-x6f26ahr 1349 12 , , , cord-028721-x6f26ahr 1349 13 abnormal abnormal JJ cord-028721-x6f26ahr 1349 14 external external JJ cord-028721-x6f26ahr 1349 15 genitalia genitalia NNS cord-028721-x6f26ahr 1349 16 , , , cord-028721-x6f26ahr 1349 17 or or CC cord-028721-x6f26ahr 1349 18 abnormal abnormal JJ cord-028721-x6f26ahr 1349 19 karyotype karyotype NN cord-028721-x6f26ahr 1349 20 . . . cord-028721-x6f26ahr 1350 1 571 571 CD cord-028721-x6f26ahr 1351 1 The the DT cord-028721-x6f26ahr 1351 2 situation situation NN cord-028721-x6f26ahr 1351 3 is be VBZ cord-028721-x6f26ahr 1351 4 different different JJ cord-028721-x6f26ahr 1351 5 in in IN cord-028721-x6f26ahr 1351 6 adults adult NNS cord-028721-x6f26ahr 1351 7 because because IN cord-028721-x6f26ahr 1351 8 intratubular intratubular JJ cord-028721-x6f26ahr 1351 9 germ germ NN cord-028721-x6f26ahr 1351 10 cell cell NN cord-028721-x6f26ahr 1351 11 neoplasia neoplasia NN cord-028721-x6f26ahr 1351 12 is be VBZ cord-028721-x6f26ahr 1351 13 present present JJ cord-028721-x6f26ahr 1351 14 in in IN cord-028721-x6f26ahr 1351 15 2 2 CD cord-028721-x6f26ahr 1351 16 - - SYM cord-028721-x6f26ahr 1351 17 3 3 CD cord-028721-x6f26ahr 1351 18 % % NN cord-028721-x6f26ahr 1351 19 of of IN cord-028721-x6f26ahr 1351 20 cases case NNS cord-028721-x6f26ahr 1351 21 and and CC cord-028721-x6f26ahr 1351 22 is be VBZ cord-028721-x6f26ahr 1351 23 diffuse diffuse JJ cord-028721-x6f26ahr 1351 24 . . . cord-028721-x6f26ahr 1352 1 572 572 CD cord-028721-x6f26ahr 1352 2 , , , cord-028721-x6f26ahr 1352 3 573 573 CD cord-028721-x6f26ahr 1353 1 When when WRB cord-028721-x6f26ahr 1353 2 intratubular intratubular JJ cord-028721-x6f26ahr 1353 3 germ germ NN cord-028721-x6f26ahr 1353 4 cell cell NN cord-028721-x6f26ahr 1353 5 neoplasia neoplasia NN cord-028721-x6f26ahr 1353 6 is be VBZ cord-028721-x6f26ahr 1353 7 detected detect VBN cord-028721-x6f26ahr 1353 8 in in IN cord-028721-x6f26ahr 1353 9 a a DT cord-028721-x6f26ahr 1353 10 child child NN cord-028721-x6f26ahr 1353 11 , , , cord-028721-x6f26ahr 1353 12 further further JJ cord-028721-x6f26ahr 1353 13 examination examination NN cord-028721-x6f26ahr 1353 14 of of IN cord-028721-x6f26ahr 1353 15 the the DT cord-028721-x6f26ahr 1353 16 testis testis NN cord-028721-x6f26ahr 1353 17 and and CC cord-028721-x6f26ahr 1353 18 rebiopsy rebiopsy NN cord-028721-x6f26ahr 1353 19 after after IN cord-028721-x6f26ahr 1353 20 puberty puberty NN cord-028721-x6f26ahr 1353 21 are be VBP cord-028721-x6f26ahr 1353 22 recommended recommend VBN cord-028721-x6f26ahr 1353 23 . . . cord-028721-x6f26ahr 1354 1 574 574 CD cord-028721-x6f26ahr 1355 1 In in IN cord-028721-x6f26ahr 1355 2 adults adult NNS cord-028721-x6f26ahr 1355 3 , , , cord-028721-x6f26ahr 1355 4 if if IN cord-028721-x6f26ahr 1355 5 intratubular intratubular JJ cord-028721-x6f26ahr 1355 6 germ germ NN cord-028721-x6f26ahr 1355 7 cell cell NN cord-028721-x6f26ahr 1355 8 neoplasia neoplasia NN cord-028721-x6f26ahr 1355 9 is be VBZ cord-028721-x6f26ahr 1355 10 unilateral unilateral JJ cord-028721-x6f26ahr 1355 11 orchidectomy orchidectomy NN cord-028721-x6f26ahr 1355 12 should should MD cord-028721-x6f26ahr 1355 13 be be VB cord-028721-x6f26ahr 1355 14 performed perform VBN cord-028721-x6f26ahr 1355 15 , , , cord-028721-x6f26ahr 1355 16 but but CC cord-028721-x6f26ahr 1355 17 if if IN cord-028721-x6f26ahr 1355 18 it -PRON- PRP cord-028721-x6f26ahr 1355 19 is be VBZ cord-028721-x6f26ahr 1355 20 bilateral bilateral JJ cord-028721-x6f26ahr 1355 21 , , , cord-028721-x6f26ahr 1355 22 radiation radiation NN cord-028721-x6f26ahr 1355 23 may may MD cord-028721-x6f26ahr 1355 24 be be VB cord-028721-x6f26ahr 1355 25 used use VBN cord-028721-x6f26ahr 1355 26 to to TO cord-028721-x6f26ahr 1355 27 eradicate eradicate VB cord-028721-x6f26ahr 1355 28 the the DT cord-028721-x6f26ahr 1355 29 neoplasia neoplasia NN cord-028721-x6f26ahr 1355 30 while while IN cord-028721-x6f26ahr 1355 31 maintaining maintain VBG cord-028721-x6f26ahr 1355 32 Leydig Leydig NNP cord-028721-x6f26ahr 1355 33 cell cell NN cord-028721-x6f26ahr 1355 34 function function NN cord-028721-x6f26ahr 1355 35 . . . cord-028721-x6f26ahr 1356 1 575 575 CD cord-028721-x6f26ahr 1356 2 Testicular Testicular NNP cord-028721-x6f26ahr 1356 3 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1356 4 ( ( -LRB- cord-028721-x6f26ahr 1356 5 TM TM NNP cord-028721-x6f26ahr 1356 6 ) ) -RRB- cord-028721-x6f26ahr 1356 7 is be VBZ cord-028721-x6f26ahr 1356 8 characterized characterize VBN cord-028721-x6f26ahr 1356 9 by by IN cord-028721-x6f26ahr 1356 10 the the DT cord-028721-x6f26ahr 1356 11 presence presence NN cord-028721-x6f26ahr 1356 12 of of IN cord-028721-x6f26ahr 1356 13 numerous numerous JJ cord-028721-x6f26ahr 1356 14 calcifi calcifi NN cord-028721-x6f26ahr 1356 15 cations cation NNS cord-028721-x6f26ahr 1356 16 diffusely diffusely RB cord-028721-x6f26ahr 1356 17 distributed distribute VBN cord-028721-x6f26ahr 1356 18 throughout throughout IN cord-028721-x6f26ahr 1356 19 the the DT cord-028721-x6f26ahr 1356 20 testicular testicular JJ cord-028721-x6f26ahr 1356 21 parenchyma parenchyma NN cord-028721-x6f26ahr 1356 22 . . . cord-028721-x6f26ahr 1357 1 The the DT cord-028721-x6f26ahr 1357 2 number number NN cord-028721-x6f26ahr 1357 3 and and CC cord-028721-x6f26ahr 1357 4 size size NN cord-028721-x6f26ahr 1357 5 of of IN cord-028721-x6f26ahr 1357 6 the the DT cord-028721-x6f26ahr 1357 7 calcifi calcifi NN cord-028721-x6f26ahr 1357 8 cations cation NNS cord-028721-x6f26ahr 1357 9 often often RB cord-028721-x6f26ahr 1357 10 is be VBZ cord-028721-x6f26ahr 1357 11 great great JJ cord-028721-x6f26ahr 1357 12 enough enough RB cord-028721-x6f26ahr 1357 13 to to TO cord-028721-x6f26ahr 1357 14 be be VB cord-028721-x6f26ahr 1357 15 detected detect VBN cord-028721-x6f26ahr 1357 16 radiographically radiographically RB cord-028721-x6f26ahr 1357 17 or or CC cord-028721-x6f26ahr 1357 18 by by IN cord-028721-x6f26ahr 1357 19 ultrasound ultrasound NN cord-028721-x6f26ahr 1357 20 . . . cord-028721-x6f26ahr 1358 1 576 576 CD cord-028721-x6f26ahr 1358 2 Isolated isolate VBN cord-028721-x6f26ahr 1358 3 microliths microlith NNS cord-028721-x6f26ahr 1358 4 have have VBP cord-028721-x6f26ahr 1358 5 been be VBN cord-028721-x6f26ahr 1358 6 reported report VBN cord-028721-x6f26ahr 1358 7 in in IN cord-028721-x6f26ahr 1358 8 undescended undescended JJ cord-028721-x6f26ahr 1358 9 testes testis NNS cord-028721-x6f26ahr 1358 10 , , , cord-028721-x6f26ahr 1358 11 prepubertal prepubertal JJ cord-028721-x6f26ahr 1358 12 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 1358 13 's 's POS cord-028721-x6f26ahr 1358 14 syndrome syndrome NN cord-028721-x6f26ahr 1358 15 , , , cord-028721-x6f26ahr 1358 16 male male JJ cord-028721-x6f26ahr 1358 17 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1358 18 , , , cord-028721-x6f26ahr 1358 19 and and CC cord-028721-x6f26ahr 1358 20 otherwise otherwise RB cord-028721-x6f26ahr 1358 21 normal normal JJ cord-028721-x6f26ahr 1358 22 children child NNS cord-028721-x6f26ahr 1358 23 and and CC cord-028721-x6f26ahr 1358 24 patients patient NNS cord-028721-x6f26ahr 1358 25 studied study VBD cord-028721-x6f26ahr 1358 26 for for IN cord-028721-x6f26ahr 1358 27 other other JJ cord-028721-x6f26ahr 1358 28 diseases disease NNS cord-028721-x6f26ahr 1358 29 . . . cord-028721-x6f26ahr 1359 1 577 577 CD cord-028721-x6f26ahr 1360 1 In in IN cord-028721-x6f26ahr 1360 2 adults adult NNS cord-028721-x6f26ahr 1360 3 , , , cord-028721-x6f26ahr 1360 4 microliths microlith NNS cord-028721-x6f26ahr 1360 5 are be VBP cord-028721-x6f26ahr 1360 6 frequently frequently RB cord-028721-x6f26ahr 1360 7 observed observe VBN cord-028721-x6f26ahr 1360 8 in in IN cord-028721-x6f26ahr 1360 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1360 10 and and CC cord-028721-x6f26ahr 1360 11 ex ex JJ cord-028721-x6f26ahr 1360 12 - - JJ cord-028721-x6f26ahr 1360 13 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1360 14 testes testis NNS cord-028721-x6f26ahr 1360 15 , , , cord-028721-x6f26ahr 1360 16 578 578 CD cord-028721-x6f26ahr 1360 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 1360 18 tubules tubule NNS cord-028721-x6f26ahr 1360 19 located locate VBN cord-028721-x6f26ahr 1360 20 at at IN cord-028721-x6f26ahr 1360 21 the the DT cord-028721-x6f26ahr 1360 22 periphery periphery NN cord-028721-x6f26ahr 1360 23 of of IN cord-028721-x6f26ahr 1360 24 germ germ NN cord-028721-x6f26ahr 1360 25 cell cell NN cord-028721-x6f26ahr 1360 26 tumor tumor NN cord-028721-x6f26ahr 1360 27 , , , cord-028721-x6f26ahr 1360 28 579 579 CD cord-028721-x6f26ahr 1360 29 infertile infertile JJ cord-028721-x6f26ahr 1360 30 patients patient NNS cord-028721-x6f26ahr 1360 31 , , , cord-028721-x6f26ahr 1360 32 [ [ -LRB- cord-028721-x6f26ahr 1360 33 580 580 CD cord-028721-x6f26ahr 1360 34 ] ] -RRB- cord-028721-x6f26ahr 1360 35 [ [ -LRB- cord-028721-x6f26ahr 1360 36 581 581 CD cord-028721-x6f26ahr 1360 37 ] ] -RRB- cord-028721-x6f26ahr 1360 38 [ [ -LRB- cord-028721-x6f26ahr 1360 39 582 582 CD cord-028721-x6f26ahr 1360 40 ] ] -RRB- cord-028721-x6f26ahr 1360 41 and and CC cord-028721-x6f26ahr 1360 42 in in IN cord-028721-x6f26ahr 1360 43 some some DT cord-028721-x6f26ahr 1360 44 patients patient NNS cord-028721-x6f26ahr 1360 45 complaining complain VBG cord-028721-x6f26ahr 1360 46 of of IN cord-028721-x6f26ahr 1360 47 orchialgia orchialgia NNP cord-028721-x6f26ahr 1360 48 583 583 CD cord-028721-x6f26ahr 1360 49 , , , cord-028721-x6f26ahr 1360 50 584 584 CD cord-028721-x6f26ahr 1360 51 or or CC cord-028721-x6f26ahr 1360 52 testicular testicular JJ cord-028721-x6f26ahr 1360 53 asymmetry asymmetry NN cord-028721-x6f26ahr 1360 54 . . . cord-028721-x6f26ahr 1361 1 585 585 CD cord-028721-x6f26ahr 1361 2 Testicular Testicular NNP cord-028721-x6f26ahr 1361 3 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1361 4 occurs occur VBZ cord-028721-x6f26ahr 1361 5 in in IN cord-028721-x6f26ahr 1361 6 0.3 0.3 CD cord-028721-x6f26ahr 1361 7 % % NN cord-028721-x6f26ahr 1361 8 of of IN cord-028721-x6f26ahr 1361 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1361 10 testes testis NNS cord-028721-x6f26ahr 1361 11 and and CC cord-028721-x6f26ahr 1361 12 is be VBZ cord-028721-x6f26ahr 1361 13 slightly slightly RB cord-028721-x6f26ahr 1361 14 more more RBR cord-028721-x6f26ahr 1361 15 common common JJ cord-028721-x6f26ahr 1361 16 in in IN cord-028721-x6f26ahr 1361 17 prepubertal prepubertal JJ cord-028721-x6f26ahr 1361 18 than than IN cord-028721-x6f26ahr 1361 19 adult adult NN cord-028721-x6f26ahr 1361 20 testes testis NNS cord-028721-x6f26ahr 1361 21 . . . cord-028721-x6f26ahr 1362 1 In in IN cord-028721-x6f26ahr 1362 2 adults adult NNS cord-028721-x6f26ahr 1362 3 , , , cord-028721-x6f26ahr 1362 4 it -PRON- PRP cord-028721-x6f26ahr 1362 5 usually usually RB cord-028721-x6f26ahr 1362 6 is be VBZ cord-028721-x6f26ahr 1362 7 diagnosed diagnose VBN cord-028721-x6f26ahr 1362 8 when when WRB cord-028721-x6f26ahr 1362 9 men man NNS cord-028721-x6f26ahr 1362 10 seek seek VBP cord-028721-x6f26ahr 1362 11 help help NN cord-028721-x6f26ahr 1362 12 for for IN cord-028721-x6f26ahr 1362 13 infertility infertility NN cord-028721-x6f26ahr 1362 14 , , , cord-028721-x6f26ahr 1362 15 pain pain NN cord-028721-x6f26ahr 1362 16 , , , cord-028721-x6f26ahr 1362 17 or or CC cord-028721-x6f26ahr 1362 18 testicular testicular JJ cord-028721-x6f26ahr 1362 19 asymmetry asymmetry NN cord-028721-x6f26ahr 1362 20 . . . cord-028721-x6f26ahr 1363 1 581 581 CD cord-028721-x6f26ahr 1364 1 Microlithiasis Microlithiasis NNP cord-028721-x6f26ahr 1364 2 has have VBZ cord-028721-x6f26ahr 1364 3 been be VBN cord-028721-x6f26ahr 1364 4 observed observe VBN cord-028721-x6f26ahr 1364 5 in in IN cord-028721-x6f26ahr 1364 6 1.4 1.4 CD cord-028721-x6f26ahr 1364 7 - - SYM cord-028721-x6f26ahr 1364 8 2 2 CD cord-028721-x6f26ahr 1364 9 % % NN cord-028721-x6f26ahr 1364 10 of of IN cord-028721-x6f26ahr 1364 11 testicular testicular JJ cord-028721-x6f26ahr 1364 12 echographies echography NNS cord-028721-x6f26ahr 1364 13 of of IN cord-028721-x6f26ahr 1364 14 different different JJ cord-028721-x6f26ahr 1364 15 disorders disorder NNS cord-028721-x6f26ahr 1364 16 . . . cord-028721-x6f26ahr 1365 1 586 586 CD cord-028721-x6f26ahr 1365 2 , , , cord-028721-x6f26ahr 1365 3 587 587 CD cord-028721-x6f26ahr 1366 1 In in IN cord-028721-x6f26ahr 1366 2 infertile infertile JJ cord-028721-x6f26ahr 1366 3 patients patient NNS cord-028721-x6f26ahr 1366 4 the the DT cord-028721-x6f26ahr 1366 5 incidence incidence NN cord-028721-x6f26ahr 1366 6 is be VBZ cord-028721-x6f26ahr 1366 7 slightly slightly RB cord-028721-x6f26ahr 1366 8 higher high JJR cord-028721-x6f26ahr 1366 9 . . . cord-028721-x6f26ahr 1367 1 Microlithiasis Microlithiasis NNP cord-028721-x6f26ahr 1367 2 is be VBZ cord-028721-x6f26ahr 1367 3 present present JJ cord-028721-x6f26ahr 1367 4 in in IN cord-028721-x6f26ahr 1367 5 35 35 CD cord-028721-x6f26ahr 1367 6 % % NN cord-028721-x6f26ahr 1367 7 of of IN cord-028721-x6f26ahr 1367 8 testis testis NN cord-028721-x6f26ahr 1367 9 having have VBG cord-028721-x6f26ahr 1367 10 a a DT cord-028721-x6f26ahr 1367 11 malignant malignant JJ cord-028721-x6f26ahr 1367 12 tumor tumor NN cord-028721-x6f26ahr 1367 13 . . . cord-028721-x6f26ahr 1368 1 588 588 CD cord-028721-x6f26ahr 1369 1 Ultrasound ultrasound NN cord-028721-x6f26ahr 1369 2 studies study NNS cord-028721-x6f26ahr 1369 3 reveal reveal VBP cord-028721-x6f26ahr 1369 4 two two CD cord-028721-x6f26ahr 1369 5 types type NNS cord-028721-x6f26ahr 1369 6 of of IN cord-028721-x6f26ahr 1369 7 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1369 8 : : : cord-028721-x6f26ahr 1369 9 classic classic JJ cord-028721-x6f26ahr 1369 10 TM TM NNP cord-028721-x6f26ahr 1369 11 , , , cord-028721-x6f26ahr 1369 12 in in IN cord-028721-x6f26ahr 1369 13 which which WDT cord-028721-x6f26ahr 1369 14 the the DT cord-028721-x6f26ahr 1369 15 number number NN cord-028721-x6f26ahr 1369 16 of of IN cord-028721-x6f26ahr 1369 17 microliths microlith NNS cord-028721-x6f26ahr 1369 18 is be VBZ cord-028721-x6f26ahr 1369 19 fi fi NNP cord-028721-x6f26ahr 1369 20 ve ve VBN cord-028721-x6f26ahr 1369 21 or or CC cord-028721-x6f26ahr 1369 22 more more JJR cord-028721-x6f26ahr 1369 23 ; ; : cord-028721-x6f26ahr 1369 24 and and CC cord-028721-x6f26ahr 1369 25 limited limit VBD cord-028721-x6f26ahr 1369 26 TM TM NNP cord-028721-x6f26ahr 1369 27 , , , cord-028721-x6f26ahr 1369 28 when when WRB cord-028721-x6f26ahr 1369 29 there there EX cord-028721-x6f26ahr 1369 30 are be VBP cord-028721-x6f26ahr 1369 31 fewer few JJR cord-028721-x6f26ahr 1369 32 than than IN cord-028721-x6f26ahr 1369 33 fi fi NNP cord-028721-x6f26ahr 1369 34 ve ve FW cord-028721-x6f26ahr 1369 35 microliths microliths NNP cord-028721-x6f26ahr 1369 36 ( ( -LRB- cord-028721-x6f26ahr 1369 37 Fig Fig NNP cord-028721-x6f26ahr 1369 38 . . . cord-028721-x6f26ahr 1369 39 12 12 CD cord-028721-x6f26ahr 1369 40 - - SYM cord-028721-x6f26ahr 1369 41 58 58 CD cord-028721-x6f26ahr 1369 42 ) ) -RRB- cord-028721-x6f26ahr 1369 43 . . . cord-028721-x6f26ahr 1370 1 The the DT cord-028721-x6f26ahr 1370 2 incidences incidence NNS cord-028721-x6f26ahr 1370 3 of of IN cord-028721-x6f26ahr 1370 4 TM TM NNP cord-028721-x6f26ahr 1370 5 in in IN cord-028721-x6f26ahr 1370 6 these these DT cord-028721-x6f26ahr 1370 7 studies study NNS cord-028721-x6f26ahr 1370 8 are be VBP cord-028721-x6f26ahr 1370 9 lower low JJR cord-028721-x6f26ahr 1370 10 than than IN cord-028721-x6f26ahr 1370 11 1 1 CD cord-028721-x6f26ahr 1370 12 % % NN cord-028721-x6f26ahr 1370 13 in in IN cord-028721-x6f26ahr 1370 14 infants infant NNS cord-028721-x6f26ahr 1370 15 , , , cord-028721-x6f26ahr 1370 16 5.6 5.6 CD cord-028721-x6f26ahr 1370 17 % % NN cord-028721-x6f26ahr 1370 18 in in IN cord-028721-x6f26ahr 1370 19 the the DT cord-028721-x6f26ahr 1370 20 general general JJ cord-028721-x6f26ahr 1370 21 population population NN cord-028721-x6f26ahr 1370 22 aged age VBN cord-028721-x6f26ahr 1370 23 between between IN cord-028721-x6f26ahr 1370 24 18 18 CD cord-028721-x6f26ahr 1370 25 and and CC cord-028721-x6f26ahr 1370 26 35 35 CD cord-028721-x6f26ahr 1370 27 years year NNS cord-028721-x6f26ahr 1370 28 ( ( -LRB- cord-028721-x6f26ahr 1370 29 bilateral bilateral JJ cord-028721-x6f26ahr 1370 30 in in IN cord-028721-x6f26ahr 1370 31 66 66 CD cord-028721-x6f26ahr 1370 32 % % NN cord-028721-x6f26ahr 1370 33 of of IN cord-028721-x6f26ahr 1370 34 patients patient NNS cord-028721-x6f26ahr 1370 35 showing show VBG cord-028721-x6f26ahr 1370 36 microliths microlith NNS cord-028721-x6f26ahr 1370 37 , , , cord-028721-x6f26ahr 1370 38 589 589 CD cord-028721-x6f26ahr 1370 39 0.68 0.68 CD cord-028721-x6f26ahr 1370 40 - - SYM cord-028721-x6f26ahr 1370 41 4.1 4.1 CD cord-028721-x6f26ahr 1370 42 % % NN cord-028721-x6f26ahr 1370 43 in in IN cord-028721-x6f26ahr 1370 44 patients patient NNS cord-028721-x6f26ahr 1370 45 with with IN cord-028721-x6f26ahr 1370 46 other other JJ cord-028721-x6f26ahr 1370 47 disorders disorder NNS cord-028721-x6f26ahr 1370 48 , , , cord-028721-x6f26ahr 1370 49 586,587,590 586,587,590 CD cord-028721-x6f26ahr 1370 50 - - SYM cord-028721-x6f26ahr 1370 51 592 592 CD cord-028721-x6f26ahr 1370 52 from from IN cord-028721-x6f26ahr 1370 53 4.6 4.6 CD cord-028721-x6f26ahr 1370 54 % % NN cord-028721-x6f26ahr 1370 55 593 593 CD cord-028721-x6f26ahr 1370 56 to to TO cord-028721-x6f26ahr 1370 57 20 20 CD cord-028721-x6f26ahr 1370 58 % % NN cord-028721-x6f26ahr 1370 59 594 594 CD cord-028721-x6f26ahr 1370 60 in in IN cord-028721-x6f26ahr 1370 61 subfertile subfertile NN cord-028721-x6f26ahr 1370 62 patients patient NNS cord-028721-x6f26ahr 1370 63 , , , cord-028721-x6f26ahr 1370 64 9.52 9.52 CD cord-028721-x6f26ahr 1370 65 % % NN cord-028721-x6f26ahr 1370 66 in in IN cord-028721-x6f26ahr 1370 67 ex ex JJ cord-028721-x6f26ahr 1370 68 - - JJ cord-028721-x6f26ahr 1370 69 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1370 70 testes testis NNS cord-028721-x6f26ahr 1370 71 , , , cord-028721-x6f26ahr 1370 72 595 595 CD cord-028721-x6f26ahr 1370 73 and and CC cord-028721-x6f26ahr 1370 74 more more JJR cord-028721-x6f26ahr 1370 75 than than IN cord-028721-x6f26ahr 1370 76 30 30 CD cord-028721-x6f26ahr 1370 77 % % NN cord-028721-x6f26ahr 1370 78 in in IN cord-028721-x6f26ahr 1370 79 adult adult NN cord-028721-x6f26ahr 1370 80 testes testis NNS cord-028721-x6f26ahr 1370 81 with with IN cord-028721-x6f26ahr 1370 82 germ germ NN cord-028721-x6f26ahr 1370 83 cell cell NN cord-028721-x6f26ahr 1370 84 tumors tumor NNS cord-028721-x6f26ahr 1370 85 ) ) -RRB- cord-028721-x6f26ahr 1370 86 . . . cord-028721-x6f26ahr 1371 1 588,596 588,596 CD cord-028721-x6f26ahr 1371 2 - - SYM cord-028721-x6f26ahr 1371 3 599 599 CD cord-028721-x6f26ahr 1371 4 Several several JJ cord-028721-x6f26ahr 1371 5 cases case NNS cord-028721-x6f26ahr 1371 6 of of IN cord-028721-x6f26ahr 1371 7 testicular testicular JJ cord-028721-x6f26ahr 1371 8 microlithiasis microlithiasi NNS cord-028721-x6f26ahr 1371 9 have have VBP cord-028721-x6f26ahr 1371 10 also also RB cord-028721-x6f26ahr 1371 11 been be VBN cord-028721-x6f26ahr 1371 12 observed observe VBN cord-028721-x6f26ahr 1371 13 in in IN cord-028721-x6f26ahr 1371 14 infant infant NN cord-028721-x6f26ahr 1371 15 testes testis NNS cord-028721-x6f26ahr 1371 16 with with IN cord-028721-x6f26ahr 1371 17 germ germ NN cord-028721-x6f26ahr 1371 18 cell cell NN cord-028721-x6f26ahr 1371 19 tumor tumor NN cord-028721-x6f26ahr 1371 20 or or CC cord-028721-x6f26ahr 1371 21 gonadal gonadal JJ cord-028721-x6f26ahr 1371 22 stroma stroma NN cord-028721-x6f26ahr 1371 23 tumor tumor NN cord-028721-x6f26ahr 1371 24 . . . cord-028721-x6f26ahr 1372 1 600 600 CD cord-028721-x6f26ahr 1372 2 , , , cord-028721-x6f26ahr 1372 3 601 601 CD cord-028721-x6f26ahr 1373 1 The the DT cord-028721-x6f26ahr 1373 2 incidence incidence NN cord-028721-x6f26ahr 1373 3 is be VBZ cord-028721-x6f26ahr 1373 4 higher high JJR cord-028721-x6f26ahr 1373 5 in in IN cord-028721-x6f26ahr 1373 6 whites white NNS cord-028721-x6f26ahr 1373 7 than than IN cord-028721-x6f26ahr 1373 8 in in IN cord-028721-x6f26ahr 1373 9 blacks black NNS cord-028721-x6f26ahr 1373 10 . . . cord-028721-x6f26ahr 1374 1 Pain pain NN cord-028721-x6f26ahr 1374 2 is be VBZ cord-028721-x6f26ahr 1374 3 the the DT cord-028721-x6f26ahr 1374 4 most most RBS cord-028721-x6f26ahr 1374 5 common common JJ cord-028721-x6f26ahr 1374 6 clinical clinical JJ cord-028721-x6f26ahr 1374 7 symptom symptom NN cord-028721-x6f26ahr 1374 8 in in IN cord-028721-x6f26ahr 1374 9 patients patient NNS cord-028721-x6f26ahr 1374 10 without without IN cord-028721-x6f26ahr 1374 11 a a DT cord-028721-x6f26ahr 1374 12 palpable palpable JJ cord-028721-x6f26ahr 1374 13 testicular testicular NN cord-028721-x6f26ahr 1374 14 mass mass NN cord-028721-x6f26ahr 1374 15 , , , cord-028721-x6f26ahr 1374 16 and and CC cord-028721-x6f26ahr 1374 17 has have VBZ cord-028721-x6f26ahr 1374 18 been be VBN cord-028721-x6f26ahr 1374 19 attributed attribute VBN cord-028721-x6f26ahr 1374 20 to to IN cord-028721-x6f26ahr 1374 21 dilation dilation NN cord-028721-x6f26ahr 1374 22 of of IN cord-028721-x6f26ahr 1374 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 1374 24 tubules tubule NNS cord-028721-x6f26ahr 1374 25 secondary secondary JJ cord-028721-x6f26ahr 1374 26 to to IN cord-028721-x6f26ahr 1374 27 obstruction obstruction NN cord-028721-x6f26ahr 1374 28 by by IN cord-028721-x6f26ahr 1374 29 microliths microlith NNS cord-028721-x6f26ahr 1374 30 . . . cord-028721-x6f26ahr 1375 1 Microliths Microliths NNP cord-028721-x6f26ahr 1375 2 are be VBP cord-028721-x6f26ahr 1375 3 made make VBN cord-028721-x6f26ahr 1375 4 by by IN cord-028721-x6f26ahr 1375 5 hydroxyapatite hydroxyapatite NN cord-028721-x6f26ahr 1375 6 , , , cord-028721-x6f26ahr 1375 7 according accord VBG cord-028721-x6f26ahr 1375 8 to to IN cord-028721-x6f26ahr 1375 9 X x NN cord-028721-x6f26ahr 1375 10 - - NN cord-028721-x6f26ahr 1375 11 ray ray NN cord-028721-x6f26ahr 1375 12 diffraction diffraction NN cord-028721-x6f26ahr 1375 13 studies study NNS cord-028721-x6f26ahr 1375 14 602 602 CD cord-028721-x6f26ahr 1375 15 and and CC cord-028721-x6f26ahr 1375 16 Raman Raman NNP cord-028721-x6f26ahr 1375 17 spectroscopy spectroscopy NN cord-028721-x6f26ahr 1375 18 . . . cord-028721-x6f26ahr 1376 1 603 603 CD cord-028721-x6f26ahr 1377 1 In in IN cord-028721-x6f26ahr 1377 2 the the DT cord-028721-x6f26ahr 1377 3 prepubertal prepubertal JJ cord-028721-x6f26ahr 1377 4 testis testis NN cord-028721-x6f26ahr 1377 5 , , , cord-028721-x6f26ahr 1377 6 microliths microlith NNS cord-028721-x6f26ahr 1377 7 are be VBP cord-028721-x6f26ahr 1377 8 surrounded surround VBN cord-028721-x6f26ahr 1377 9 by by IN cord-028721-x6f26ahr 1377 10 a a DT cord-028721-x6f26ahr 1377 11 double double JJ cord-028721-x6f26ahr 1377 12 layer layer NN cord-028721-x6f26ahr 1377 13 of of IN cord-028721-x6f26ahr 1377 14 Sertoli sertoli JJ cord-028721-x6f26ahr 1377 15 cells cell NNS cord-028721-x6f26ahr 1377 16 and and CC cord-028721-x6f26ahr 1377 17 measure measure VB cord-028721-x6f26ahr 1377 18 up up RP cord-028721-x6f26ahr 1377 19 to to TO cord-028721-x6f26ahr 1377 20 300 300 CD cord-028721-x6f26ahr 1377 21 µm µm NN cord-028721-x6f26ahr 1377 22 in in IN cord-028721-x6f26ahr 1377 23 diameter diameter NN cord-028721-x6f26ahr 1377 24 . . . cord-028721-x6f26ahr 1378 1 When when WRB cord-028721-x6f26ahr 1378 2 they -PRON- PRP cord-028721-x6f26ahr 1378 3 are be VBP cord-028721-x6f26ahr 1378 4 very very RB cord-028721-x6f26ahr 1378 5 large large JJ cord-028721-x6f26ahr 1378 6 , , , cord-028721-x6f26ahr 1378 7 the the DT cord-028721-x6f26ahr 1378 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 1378 9 epithelium epithelium NN cord-028721-x6f26ahr 1378 10 may may MD cord-028721-x6f26ahr 1378 11 be be VB cord-028721-x6f26ahr 1378 12 destroyed destroy VBN cord-028721-x6f26ahr 1378 13 and and CC cord-028721-x6f26ahr 1378 14 the the DT cord-028721-x6f26ahr 1378 15 microlith microlith NN cord-028721-x6f26ahr 1378 16 is be VBZ cord-028721-x6f26ahr 1378 17 surrounded surround VBN cord-028721-x6f26ahr 1378 18 by by IN cord-028721-x6f26ahr 1378 19 peritubular peritubular NNP cord-028721-x6f26ahr 1378 20 cells cell NNS cord-028721-x6f26ahr 1378 21 ( ( -LRB- cord-028721-x6f26ahr 1378 22 Fig Fig NNP cord-028721-x6f26ahr 1378 23 . . . cord-028721-x6f26ahr 1378 24 12 12 CD cord-028721-x6f26ahr 1378 25 - - SYM cord-028721-x6f26ahr 1378 26 59 59 CD cord-028721-x6f26ahr 1378 27 ) ) -RRB- cord-028721-x6f26ahr 1378 28 . . . cord-028721-x6f26ahr 1379 1 Testes testis NNS cord-028721-x6f26ahr 1379 2 with with IN cord-028721-x6f26ahr 1379 3 microliths microlith NNS cord-028721-x6f26ahr 1379 4 have have VBP cord-028721-x6f26ahr 1379 5 subnormal subnormal JJ cord-028721-x6f26ahr 1379 6 mean mean JJ cord-028721-x6f26ahr 1379 7 tubular tubular JJ cord-028721-x6f26ahr 1379 8 diameters diameter NNS cord-028721-x6f26ahr 1379 9 and and CC cord-028721-x6f26ahr 1379 10 tubular tubular JJ cord-028721-x6f26ahr 1379 11 fertility fertility NN cord-028721-x6f26ahr 1379 12 index index NN cord-028721-x6f26ahr 1379 13 . . . cord-028721-x6f26ahr 1380 1 604 604 CD cord-028721-x6f26ahr 1381 1 In in IN cord-028721-x6f26ahr 1381 2 adult adult NN cord-028721-x6f26ahr 1381 3 testes testis NNS cord-028721-x6f26ahr 1381 4 with with IN cord-028721-x6f26ahr 1381 5 microliths microlith NNS cord-028721-x6f26ahr 1381 6 there there EX cord-028721-x6f26ahr 1381 7 is be VBZ cord-028721-x6f26ahr 1381 8 incomplete incomplete JJ cord-028721-x6f26ahr 1381 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1381 10 . . . cord-028721-x6f26ahr 1382 1 Some some DT cord-028721-x6f26ahr 1382 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1382 3 tubules tubule NNS cord-028721-x6f26ahr 1382 4 with with IN cord-028721-x6f26ahr 1382 5 microliths microlith NNS cord-028721-x6f26ahr 1382 6 are be VBP cord-028721-x6f26ahr 1382 7 cystically cystically RB cord-028721-x6f26ahr 1382 8 dilated dilate VBN cord-028721-x6f26ahr 1382 9 ( ( -LRB- cord-028721-x6f26ahr 1382 10 Fig fig NN cord-028721-x6f26ahr 1382 11 . . . cord-028721-x6f26ahr 1382 12 12 12 CD cord-028721-x6f26ahr 1382 13 - - SYM cord-028721-x6f26ahr 1382 14 60 60 CD cord-028721-x6f26ahr 1382 15 ) ) -RRB- cord-028721-x6f26ahr 1382 16 . . . cord-028721-x6f26ahr 1383 1 Microliths microlith NNS cord-028721-x6f26ahr 1383 2 arise arise VBP cord-028721-x6f26ahr 1383 3 as as IN cord-028721-x6f26ahr 1383 4 extratubular extratubular JJ cord-028721-x6f26ahr 1383 5 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 1383 6 bodies body NNS cord-028721-x6f26ahr 1383 7 that that WDT cord-028721-x6f26ahr 1383 8 mineralize mineralize VBP cord-028721-x6f26ahr 1383 9 and and CC cord-028721-x6f26ahr 1383 10 pass pass VB cord-028721-x6f26ahr 1383 11 into into IN cord-028721-x6f26ahr 1383 12 the the DT cord-028721-x6f26ahr 1383 13 tubular tubular JJ cord-028721-x6f26ahr 1383 14 lumina lumina NNP cord-028721-x6f26ahr 1383 15 . . . cord-028721-x6f26ahr 1384 1 605 605 CD cord-028721-x6f26ahr 1385 1 Microlithiasis Microlithiasis NNP cord-028721-x6f26ahr 1385 2 may may MD cord-028721-x6f26ahr 1385 3 be be VB cord-028721-x6f26ahr 1385 4 a a DT cord-028721-x6f26ahr 1385 5 disorder disorder NN cord-028721-x6f26ahr 1385 6 of of IN cord-028721-x6f26ahr 1385 7 the the DT cord-028721-x6f26ahr 1385 8 tunica tunica NNP cord-028721-x6f26ahr 1385 9 propria propria NNP cord-028721-x6f26ahr 1385 10 . . . cord-028721-x6f26ahr 1386 1 Also also RB cord-028721-x6f26ahr 1386 2 , , , cord-028721-x6f26ahr 1386 3 testicular testicular NNP cord-028721-x6f26ahr 1386 4 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1386 5 is be VBZ cord-028721-x6f26ahr 1386 6 occasionally occasionally RB cord-028721-x6f26ahr 1386 7 associated associate VBN cord-028721-x6f26ahr 1386 8 with with IN cord-028721-x6f26ahr 1386 9 pulmonary pulmonary JJ cord-028721-x6f26ahr 1386 10 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1386 11 and and CC cord-028721-x6f26ahr 1386 12 with with IN cord-028721-x6f26ahr 1386 13 calcifi calcifi NN cord-028721-x6f26ahr 1386 14 cations cation NNS cord-028721-x6f26ahr 1386 15 in in IN cord-028721-x6f26ahr 1386 16 the the DT cord-028721-x6f26ahr 1386 17 parasympathetic parasympathetic JJ cord-028721-x6f26ahr 1386 18 nervous nervous JJ cord-028721-x6f26ahr 1386 19 system system NN cord-028721-x6f26ahr 1386 20 . . . cord-028721-x6f26ahr 1387 1 606 606 CD cord-028721-x6f26ahr 1387 2 , , , cord-028721-x6f26ahr 1387 3 607 607 CD cord-028721-x6f26ahr 1388 1 The the DT cord-028721-x6f26ahr 1388 2 association association NN cord-028721-x6f26ahr 1388 3 of of IN cord-028721-x6f26ahr 1388 4 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1388 5 and and CC cord-028721-x6f26ahr 1388 6 testicular testicular JJ cord-028721-x6f26ahr 1388 7 cancer cancer NN cord-028721-x6f26ahr 1388 8 is be VBZ cord-028721-x6f26ahr 1388 9 controversial controversial JJ cord-028721-x6f26ahr 1388 10 . . . cord-028721-x6f26ahr 1389 1 608 608 CD cord-028721-x6f26ahr 1389 2 , , , cord-028721-x6f26ahr 1389 3 609 609 CD cord-028721-x6f26ahr 1390 1 Although although IN cord-028721-x6f26ahr 1390 2 the the DT cord-028721-x6f26ahr 1390 3 development development NN cord-028721-x6f26ahr 1390 4 of of IN cord-028721-x6f26ahr 1390 5 testicular testicular JJ cord-028721-x6f26ahr 1390 6 cancer cancer NN cord-028721-x6f26ahr 1390 7 has have VBZ cord-028721-x6f26ahr 1390 8 been be VBN cord-028721-x6f26ahr 1390 9 observed observe VBN cord-028721-x6f26ahr 1390 10 in in IN cord-028721-x6f26ahr 1390 11 several several JJ cord-028721-x6f26ahr 1390 12 patients patient NNS cord-028721-x6f26ahr 1390 13 whose whose WP$ cord-028721-x6f26ahr 1390 14 testicular testicular NNP cord-028721-x6f26ahr 1390 15 microlithiasis microlithiasi NNS cord-028721-x6f26ahr 1390 16 had have VBD cord-028721-x6f26ahr 1390 17 been be VBN cord-028721-x6f26ahr 1390 18 previously previously RB cord-028721-x6f26ahr 1390 19 diagnosed diagnose VBN cord-028721-x6f26ahr 1390 20 by by IN cord-028721-x6f26ahr 1390 21 ultrasound ultrasound NN cord-028721-x6f26ahr 1390 22 studies study NNS cord-028721-x6f26ahr 1390 23 , , , cord-028721-x6f26ahr 1390 24 [ [ -LRB- cord-028721-x6f26ahr 1390 25 610 610 CD cord-028721-x6f26ahr 1390 26 ] ] -RRB- cord-028721-x6f26ahr 1390 27 [ [ -LRB- cord-028721-x6f26ahr 1390 28 611 611 CD cord-028721-x6f26ahr 1390 29 ] ] -RRB- cord-028721-x6f26ahr 1391 1 [ [ -LRB- cord-028721-x6f26ahr 1391 2 612 612 CD cord-028721-x6f26ahr 1391 3 ] ] -RRB- cord-028721-x6f26ahr 1391 4 [ [ -LRB- cord-028721-x6f26ahr 1391 5 613 613 CD cord-028721-x6f26ahr 1391 6 ] ] -RRB- cord-028721-x6f26ahr 1392 1 [ [ -LRB- cord-028721-x6f26ahr 1392 2 614 614 CD cord-028721-x6f26ahr 1392 3 ] ] -RRB- cord-028721-x6f26ahr 1392 4 it -PRON- PRP cord-028721-x6f26ahr 1392 5 is be VBZ cord-028721-x6f26ahr 1392 6 also also RB cord-028721-x6f26ahr 1392 7 thought think VBN cord-028721-x6f26ahr 1392 8 that that IN cord-028721-x6f26ahr 1392 9 patients patient NNS cord-028721-x6f26ahr 1392 10 with with IN cord-028721-x6f26ahr 1392 11 testicular testicular JJ cord-028721-x6f26ahr 1392 12 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1392 13 not not RB cord-028721-x6f26ahr 1392 14 associated associate VBN cord-028721-x6f26ahr 1392 15 with with IN cord-028721-x6f26ahr 1392 16 other other JJ cord-028721-x6f26ahr 1392 17 disorder disorder NN cord-028721-x6f26ahr 1392 18 do do VBP cord-028721-x6f26ahr 1392 19 not not RB cord-028721-x6f26ahr 1392 20 require require VB cord-028721-x6f26ahr 1392 21 any any DT cord-028721-x6f26ahr 1392 22 follow follow NN cord-028721-x6f26ahr 1392 23 - - HYPH cord-028721-x6f26ahr 1392 24 up up NN cord-028721-x6f26ahr 1392 25 . . . cord-028721-x6f26ahr 1393 1 615 615 CD cord-028721-x6f26ahr 1394 1 When when WRB cord-028721-x6f26ahr 1394 2 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1394 3 is be VBZ cord-028721-x6f26ahr 1394 4 associated associate VBN cord-028721-x6f26ahr 1394 5 with with IN cord-028721-x6f26ahr 1394 6 infertility infertility NN cord-028721-x6f26ahr 1394 7 the the DT cord-028721-x6f26ahr 1394 8 incidence incidence NN cord-028721-x6f26ahr 1394 9 of of IN cord-028721-x6f26ahr 1394 10 cancer cancer NN cord-028721-x6f26ahr 1394 11 varies vary VBZ cord-028721-x6f26ahr 1394 12 according accord VBG cord-028721-x6f26ahr 1394 13 to to IN cord-028721-x6f26ahr 1394 14 the the DT cord-028721-x6f26ahr 1394 15 unilaterality unilaterality NN cord-028721-x6f26ahr 1394 16 or or CC cord-028721-x6f26ahr 1394 17 bilaterality bilaterality NN cord-028721-x6f26ahr 1394 18 of of IN cord-028721-x6f26ahr 1394 19 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1394 20 : : : cord-028721-x6f26ahr 1395 1 594 594 CD cord-028721-x6f26ahr 1395 2 subfertile subfertile NN cord-028721-x6f26ahr 1395 3 patients patient NNS cord-028721-x6f26ahr 1395 4 with with IN cord-028721-x6f26ahr 1395 5 unilateral unilateral JJ cord-028721-x6f26ahr 1395 6 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1395 7 show show VBP cord-028721-x6f26ahr 1395 8 no no DT cord-028721-x6f26ahr 1395 9 intratubular intratubular JJ cord-028721-x6f26ahr 1395 10 germ germ NN cord-028721-x6f26ahr 1395 11 cell cell NN cord-028721-x6f26ahr 1395 12 neoplasia neoplasia NN cord-028721-x6f26ahr 1395 13 , , , cord-028721-x6f26ahr 1395 14 whereas whereas IN cord-028721-x6f26ahr 1395 15 this this DT cord-028721-x6f26ahr 1395 16 is be VBZ cord-028721-x6f26ahr 1395 17 present present JJ cord-028721-x6f26ahr 1395 18 in in IN cord-028721-x6f26ahr 1395 19 20 20 CD cord-028721-x6f26ahr 1395 20 % % NN cord-028721-x6f26ahr 1395 21 of of IN cord-028721-x6f26ahr 1395 22 those those DT cord-028721-x6f26ahr 1395 23 with with IN cord-028721-x6f26ahr 1395 24 bilateral bilateral JJ cord-028721-x6f26ahr 1395 25 microlithiasis microlithiasi NNS cord-028721-x6f26ahr 1395 26 . . . cord-028721-x6f26ahr 1396 1 The the DT cord-028721-x6f26ahr 1396 2 risk risk NN cord-028721-x6f26ahr 1396 3 of of IN cord-028721-x6f26ahr 1396 4 malignancy malignancy NN cord-028721-x6f26ahr 1396 5 is be VBZ cord-028721-x6f26ahr 1396 6 higher high JJR cord-028721-x6f26ahr 1396 7 in in IN cord-028721-x6f26ahr 1396 8 classic classic JJ cord-028721-x6f26ahr 1396 9 than than IN cord-028721-x6f26ahr 1396 10 in in IN cord-028721-x6f26ahr 1396 11 limited limited JJ cord-028721-x6f26ahr 1396 12 TM TM NNP cord-028721-x6f26ahr 1396 13 . . . cord-028721-x6f26ahr 1397 1 616 616 CD cord-028721-x6f26ahr 1398 1 The the DT cord-028721-x6f26ahr 1398 2 nexus nexus NN cord-028721-x6f26ahr 1398 3 between between IN cord-028721-x6f26ahr 1398 4 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1398 5 and and CC cord-028721-x6f26ahr 1398 6 cancer cancer NN cord-028721-x6f26ahr 1398 7 does do VBZ cord-028721-x6f26ahr 1398 8 not not RB cord-028721-x6f26ahr 1398 9 seem seem VB cord-028721-x6f26ahr 1398 10 to to TO cord-028721-x6f26ahr 1398 11 be be VB cord-028721-x6f26ahr 1398 12 the the DT cord-028721-x6f26ahr 1398 13 predisposition predisposition NN cord-028721-x6f26ahr 1398 14 of of IN cord-028721-x6f26ahr 1398 15 one one CD cord-028721-x6f26ahr 1398 16 disorder disorder NN cord-028721-x6f26ahr 1398 17 towards towards IN cord-028721-x6f26ahr 1398 18 the the DT cord-028721-x6f26ahr 1398 19 other other JJ cord-028721-x6f26ahr 1398 20 but but CC cord-028721-x6f26ahr 1398 21 rather rather RB cord-028721-x6f26ahr 1398 22 the the DT cord-028721-x6f26ahr 1398 23 predisposition predisposition NN cord-028721-x6f26ahr 1398 24 of of IN cord-028721-x6f26ahr 1398 25 both both DT cord-028721-x6f26ahr 1398 26 to to TO cord-028721-x6f26ahr 1398 27 develop develop VB cord-028721-x6f26ahr 1398 28 in in IN cord-028721-x6f26ahr 1398 29 abnormal abnormal JJ cord-028721-x6f26ahr 1398 30 testes testis NNS cord-028721-x6f26ahr 1398 31 . . . cord-028721-x6f26ahr 1399 1 This this DT cord-028721-x6f26ahr 1399 2 may may MD cord-028721-x6f26ahr 1399 3 also also RB cord-028721-x6f26ahr 1399 4 explain explain VB cord-028721-x6f26ahr 1399 5 the the DT cord-028721-x6f26ahr 1399 6 association association NN cord-028721-x6f26ahr 1399 7 between between IN cord-028721-x6f26ahr 1399 8 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 1399 9 and and CC cord-028721-x6f26ahr 1399 10 infertility infertility NN cord-028721-x6f26ahr 1399 11 . . . cord-028721-x6f26ahr 1400 1 Yearly yearly JJ cord-028721-x6f26ahr 1400 2 ultrasound ultrasound NN cord-028721-x6f26ahr 1400 3 examination examination NN cord-028721-x6f26ahr 1400 4 , , , cord-028721-x6f26ahr 1400 5 perhaps perhaps RB cord-028721-x6f26ahr 1400 6 with with IN cord-028721-x6f26ahr 1400 7 testicular testicular JJ cord-028721-x6f26ahr 1400 8 biopsy biopsy NN cord-028721-x6f26ahr 1400 9 , , , cord-028721-x6f26ahr 1400 10 is be VBZ cord-028721-x6f26ahr 1400 11 recommended recommend VBN cord-028721-x6f26ahr 1400 12 in in IN cord-028721-x6f26ahr 1400 13 those those DT cord-028721-x6f26ahr 1400 14 with with IN cord-028721-x6f26ahr 1400 15 testicular testicular JJ cord-028721-x6f26ahr 1400 16 microlithiasis microlithiasis NN cord-028721-x6f26ahr 1400 17 associated associate VBN cord-028721-x6f26ahr 1400 18 with with IN cord-028721-x6f26ahr 1400 19 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1400 20 , , , cord-028721-x6f26ahr 1400 21 infertility infertility NN cord-028721-x6f26ahr 1400 22 , , , cord-028721-x6f26ahr 1400 23 atrophic atrophic JJ cord-028721-x6f26ahr 1400 24 testes testis NNS cord-028721-x6f26ahr 1400 25 , , , cord-028721-x6f26ahr 1400 26 or or CC cord-028721-x6f26ahr 1400 27 contralateral contralateral JJ cord-028721-x6f26ahr 1400 28 testis testis NN cord-028721-x6f26ahr 1400 29 bearing bear VBG cord-028721-x6f26ahr 1400 30 germ germ NN cord-028721-x6f26ahr 1400 31 cell cell NN cord-028721-x6f26ahr 1400 32 tumor tumor NN cord-028721-x6f26ahr 1400 33 . . . cord-028721-x6f26ahr 1401 1 617 617 CD cord-028721-x6f26ahr 1402 1 Microlithiasis Microlithiasis NNP cord-028721-x6f26ahr 1402 2 also also RB cord-028721-x6f26ahr 1402 3 occurs occur VBZ cord-028721-x6f26ahr 1402 4 in in IN cord-028721-x6f26ahr 1402 5 the the DT cord-028721-x6f26ahr 1402 6 rete rete NN cord-028721-x6f26ahr 1402 7 testis testis NN cord-028721-x6f26ahr 1402 8 or or CC cord-028721-x6f26ahr 1402 9 sperm sperm NN cord-028721-x6f26ahr 1402 10 excretory excretory JJ cord-028721-x6f26ahr 1402 11 ducts duct NNS cord-028721-x6f26ahr 1402 12 . . . cord-028721-x6f26ahr 1403 1 Epididymal Epididymal NNP cord-028721-x6f26ahr 1403 2 rupture rupture NN cord-028721-x6f26ahr 1403 3 and and CC cord-028721-x6f26ahr 1403 4 extravasation extravasation NN cord-028721-x6f26ahr 1403 5 of of IN cord-028721-x6f26ahr 1403 6 microliths microlith NNS cord-028721-x6f26ahr 1403 7 into into IN cord-028721-x6f26ahr 1403 8 the the DT cord-028721-x6f26ahr 1403 9 interductal interductal JJ cord-028721-x6f26ahr 1403 10 tissue tissue NN cord-028721-x6f26ahr 1403 11 may may MD cord-028721-x6f26ahr 1403 12 cause cause VB cord-028721-x6f26ahr 1403 13 a a DT cord-028721-x6f26ahr 1403 14 histiocytic histiocytic JJ cord-028721-x6f26ahr 1403 15 reaction reaction NN cord-028721-x6f26ahr 1403 16 resembling resemble VBG cord-028721-x6f26ahr 1403 17 malakoplakia malakoplakia NNP cord-028721-x6f26ahr 1403 18 ( ( -LRB- cord-028721-x6f26ahr 1403 19 Fig Fig NNP cord-028721-x6f26ahr 1403 20 . . . cord-028721-x6f26ahr 1403 21 12 12 CD cord-028721-x6f26ahr 1403 22 - - SYM cord-028721-x6f26ahr 1403 23 61 61 CD cord-028721-x6f26ahr 1403 24 ) ) -RRB- cord-028721-x6f26ahr 1403 25 . . . cord-028721-x6f26ahr 1404 1 The the DT cord-028721-x6f26ahr 1404 2 disorder disorder NN cord-028721-x6f26ahr 1404 3 is be VBZ cord-028721-x6f26ahr 1404 4 asymptomatic asymptomatic JJ cord-028721-x6f26ahr 1404 5 and and CC cord-028721-x6f26ahr 1404 6 not not RB cord-028721-x6f26ahr 1404 7 associated associate VBN cord-028721-x6f26ahr 1404 8 with with IN cord-028721-x6f26ahr 1404 9 testicular testicular JJ cord-028721-x6f26ahr 1404 10 cancer cancer NN cord-028721-x6f26ahr 1404 11 . . . cord-028721-x6f26ahr 1405 1 618 618 CD cord-028721-x6f26ahr 1405 2 _SP cord-028721-x6f26ahr 1406 1 Gonadal Gonadal NNP cord-028721-x6f26ahr 1406 2 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1406 3 refers refer VBZ cord-028721-x6f26ahr 1406 4 to to IN cord-028721-x6f26ahr 1406 5 disorders disorder NNS cord-028721-x6f26ahr 1406 6 characterized characterize VBN cord-028721-x6f26ahr 1406 7 by by IN cord-028721-x6f26ahr 1406 8 amenorrhea amenorrhea NN cord-028721-x6f26ahr 1406 9 and and CC cord-028721-x6f26ahr 1406 10 streak streak NN cord-028721-x6f26ahr 1406 11 gonads gonad NNS cord-028721-x6f26ahr 1406 12 in in IN cord-028721-x6f26ahr 1406 13 phenotypically phenotypically RB cord-028721-x6f26ahr 1406 14 female female JJ cord-028721-x6f26ahr 1406 15 patients patient NNS cord-028721-x6f26ahr 1406 16 . . . cord-028721-x6f26ahr 1407 1 In in IN cord-028721-x6f26ahr 1407 2 adults adult NNS cord-028721-x6f26ahr 1407 3 , , , cord-028721-x6f26ahr 1407 4 streak streak NN cord-028721-x6f26ahr 1407 5 gonads gonad NNS cord-028721-x6f26ahr 1407 6 are be VBP cord-028721-x6f26ahr 1407 7 elongated elongated JJ cord-028721-x6f26ahr 1407 8 masses masse NNS cord-028721-x6f26ahr 1407 9 of of IN cord-028721-x6f26ahr 1407 10 fi fi NN cord-028721-x6f26ahr 1407 11 brous brous JJ cord-028721-x6f26ahr 1407 12 tissue tissue NN cord-028721-x6f26ahr 1407 13 resembling resemble VBG cord-028721-x6f26ahr 1407 14 ovarian ovarian JJ cord-028721-x6f26ahr 1407 15 stroma stroma NN cord-028721-x6f26ahr 1407 16 ( ( -LRB- cord-028721-x6f26ahr 1407 17 Fig Fig NNP cord-028721-x6f26ahr 1407 18 . . . cord-028721-x6f26ahr 1407 19 12 12 CD cord-028721-x6f26ahr 1407 20 - - SYM cord-028721-x6f26ahr 1407 21 62 62 CD cord-028721-x6f26ahr 1407 22 ) ) -RRB- cord-028721-x6f26ahr 1407 23 . . . cord-028721-x6f26ahr 1408 1 They -PRON- PRP cord-028721-x6f26ahr 1408 2 may may MD cord-028721-x6f26ahr 1408 3 contain contain VB cord-028721-x6f26ahr 1408 4 hilar hilar JJ cord-028721-x6f26ahr 1408 5 cells cell NNS cord-028721-x6f26ahr 1408 6 and and CC cord-028721-x6f26ahr 1408 7 rete rete NN cord-028721-x6f26ahr 1408 8 or or CC cord-028721-x6f26ahr 1408 9 epithelial epithelial JJ cord-028721-x6f26ahr 1408 10 cords cord NNS cord-028721-x6f26ahr 1408 11 with with IN cord-028721-x6f26ahr 1408 12 variable variable JJ cord-028721-x6f26ahr 1408 13 degrees degree NNS cord-028721-x6f26ahr 1408 14 of of IN cord-028721-x6f26ahr 1408 15 maturation maturation NN cord-028721-x6f26ahr 1408 16 , , , cord-028721-x6f26ahr 1408 17 and and CC cord-028721-x6f26ahr 1408 18 may may MD cord-028721-x6f26ahr 1408 19 result result VB cord-028721-x6f26ahr 1408 20 from from IN cord-028721-x6f26ahr 1408 21 failure failure NN cord-028721-x6f26ahr 1408 22 in in IN cord-028721-x6f26ahr 1408 23 gonad gonad NN cord-028721-x6f26ahr 1408 24 formation formation NN cord-028721-x6f26ahr 1408 25 , , , cord-028721-x6f26ahr 1408 26 failure failure NN cord-028721-x6f26ahr 1408 27 of of IN cord-028721-x6f26ahr 1408 28 gonadal gonadal JJ cord-028721-x6f26ahr 1408 29 differentiation differentiation NN cord-028721-x6f26ahr 1408 30 to to IN cord-028721-x6f26ahr 1408 31 ovary ovary NN cord-028721-x6f26ahr 1408 32 , , , cord-028721-x6f26ahr 1408 33 or or CC cord-028721-x6f26ahr 1408 34 failure failure NN cord-028721-x6f26ahr 1408 35 of of IN cord-028721-x6f26ahr 1408 36 gonadal gonadal JJ cord-028721-x6f26ahr 1408 37 differentiation differentiation NN cord-028721-x6f26ahr 1408 38 to to IN cord-028721-x6f26ahr 1408 39 testis testis NN cord-028721-x6f26ahr 1408 40 . . . cord-028721-x6f26ahr 1409 1 Some some DT cord-028721-x6f26ahr 1409 2 streak streak NN cord-028721-x6f26ahr 1409 3 gonads gonad NNS cord-028721-x6f26ahr 1409 4 contain contain VBP cord-028721-x6f26ahr 1409 5 a a DT cord-028721-x6f26ahr 1409 6 few few JJ cord-028721-x6f26ahr 1409 7 ovocytes ovocyte NNS cord-028721-x6f26ahr 1409 8 or or CC cord-028721-x6f26ahr 1409 9 primordial primordial JJ cord-028721-x6f26ahr 1409 10 follicles follicle NNS cord-028721-x6f26ahr 1409 11 , , , cord-028721-x6f26ahr 1409 12 but but CC cord-028721-x6f26ahr 1409 13 all all DT cord-028721-x6f26ahr 1409 14 germ germ NN cord-028721-x6f26ahr 1409 15 cells cell NNS cord-028721-x6f26ahr 1409 16 disappear disappear VBP cord-028721-x6f26ahr 1409 17 at at IN cord-028721-x6f26ahr 1409 18 puberty puberty NN cord-028721-x6f26ahr 1409 19 . . . cord-028721-x6f26ahr 1410 1 Patients patient NNS cord-028721-x6f26ahr 1410 2 with with IN cord-028721-x6f26ahr 1410 3 streak streak NN cord-028721-x6f26ahr 1410 4 gonads gonad NNS cord-028721-x6f26ahr 1410 5 have have VBP cord-028721-x6f26ahr 1410 6 a a DT cord-028721-x6f26ahr 1410 7 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1410 8 uterus uterus NN cord-028721-x6f26ahr 1410 9 and and CC cord-028721-x6f26ahr 1410 10 fallopian fallopian JJ cord-028721-x6f26ahr 1410 11 tubes tube NNS cord-028721-x6f26ahr 1410 12 . . . cord-028721-x6f26ahr 1411 1 Four four CD cord-028721-x6f26ahr 1411 2 types type NNS cord-028721-x6f26ahr 1411 3 of of IN cord-028721-x6f26ahr 1411 4 gonadal gonadal JJ cord-028721-x6f26ahr 1411 5 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1411 6 have have VBP cord-028721-x6f26ahr 1411 7 been be VBN cord-028721-x6f26ahr 1411 8 described describe VBN cord-028721-x6f26ahr 1411 9 : : : cord-028721-x6f26ahr 1411 10 46XY 46xy CD cord-028721-x6f26ahr 1411 11 pure pure JJ cord-028721-x6f26ahr 1411 12 , , , cord-028721-x6f26ahr 1411 13 46XX 46xx CD cord-028721-x6f26ahr 1411 14 pure pure NN cord-028721-x6f26ahr 1411 15 , , , cord-028721-x6f26ahr 1411 16 45X0 45x0 CD cord-028721-x6f26ahr 1411 17 , , , cord-028721-x6f26ahr 1411 18 and and CC cord-028721-x6f26ahr 1411 19 mixed mix VBN cord-028721-x6f26ahr 1411 20 . . . cord-028721-x6f26ahr 1412 1 46XY 46xy CD cord-028721-x6f26ahr 1412 2 gonadal gonadal NNP cord-028721-x6f26ahr 1412 3 dysgenesis dysgenesis FW cord-028721-x6f26ahr 1412 4 ( ( -LRB- cord-028721-x6f26ahr 1412 5 Swyer Swyer NNP cord-028721-x6f26ahr 1412 6 's 's POS cord-028721-x6f26ahr 1412 7 syndrome syndrome NN cord-028721-x6f26ahr 1412 8 ) ) -RRB- cord-028721-x6f26ahr 1412 9 is be VBZ cord-028721-x6f26ahr 1412 10 characterized characterize VBN cord-028721-x6f26ahr 1412 11 by by IN cord-028721-x6f26ahr 1412 12 female female JJ cord-028721-x6f26ahr 1412 13 phenotype phenotype NN cord-028721-x6f26ahr 1412 14 , , , cord-028721-x6f26ahr 1412 15 absence absence NN cord-028721-x6f26ahr 1412 16 of of IN cord-028721-x6f26ahr 1412 17 Turnerian turnerian JJ cord-028721-x6f26ahr 1412 18 stigmata stigmata NN cord-028721-x6f26ahr 1412 19 , , , cord-028721-x6f26ahr 1412 20 and and CC cord-028721-x6f26ahr 1412 21 female female JJ cord-028721-x6f26ahr 1412 22 external external JJ cord-028721-x6f26ahr 1412 23 genitalia genitalia NNS cord-028721-x6f26ahr 1412 24 , , , cord-028721-x6f26ahr 1412 25 sometimes sometimes RB cord-028721-x6f26ahr 1412 26 with with IN cord-028721-x6f26ahr 1412 27 fused fuse VBN cord-028721-x6f26ahr 1412 28 labia labia NN cord-028721-x6f26ahr 1412 29 majora majora NN cord-028721-x6f26ahr 1412 30 , , , cord-028721-x6f26ahr 1412 31 a a DT cord-028721-x6f26ahr 1412 32 hypertrophic hypertrophic JJ cord-028721-x6f26ahr 1412 33 clitoris clitoris NN cord-028721-x6f26ahr 1412 34 , , , cord-028721-x6f26ahr 1412 35 and and CC cord-028721-x6f26ahr 1412 36 hypospadias hypospadia NNS cord-028721-x6f26ahr 1412 37 . . . cord-028721-x6f26ahr 1413 1 The the DT cord-028721-x6f26ahr 1413 2 breasts breast NNS cord-028721-x6f26ahr 1413 3 develop develop VBP cord-028721-x6f26ahr 1413 4 at at IN cord-028721-x6f26ahr 1413 5 puberty puberty NN cord-028721-x6f26ahr 1413 6 . . . cord-028721-x6f26ahr 1414 1 Sexual sexual JJ cord-028721-x6f26ahr 1414 2 infantilism infantilism NN cord-028721-x6f26ahr 1414 3 persists persist VBZ cord-028721-x6f26ahr 1414 4 in in IN cord-028721-x6f26ahr 1414 5 adulthood adulthood NN cord-028721-x6f26ahr 1414 6 , , , cord-028721-x6f26ahr 1414 7 and and CC cord-028721-x6f26ahr 1414 8 eunuchoidism eunuchoidism NN cord-028721-x6f26ahr 1414 9 and and CC cord-028721-x6f26ahr 1414 10 amenorrhea amenorrhea NN cord-028721-x6f26ahr 1414 11 appear appear VBP cord-028721-x6f26ahr 1414 12 . . . cord-028721-x6f26ahr 1415 1 These these DT cord-028721-x6f26ahr 1415 2 patients patient NNS cord-028721-x6f26ahr 1415 3 have have VBP cord-028721-x6f26ahr 1415 4 elevated elevate VBN cord-028721-x6f26ahr 1415 5 serum serum NN cord-028721-x6f26ahr 1415 6 gonadotropin gonadotropin NN cord-028721-x6f26ahr 1415 7 levels level NNS cord-028721-x6f26ahr 1415 8 and and CC cord-028721-x6f26ahr 1415 9 low low JJ cord-028721-x6f26ahr 1415 10 serum serum NN cord-028721-x6f26ahr 1415 11 estradiol estradiol NN cord-028721-x6f26ahr 1415 12 . . . cord-028721-x6f26ahr 1416 1 There there EX cord-028721-x6f26ahr 1416 2 are be VBP cord-028721-x6f26ahr 1416 3 two two CD cord-028721-x6f26ahr 1416 4 types type NNS cord-028721-x6f26ahr 1416 5 of of IN cord-028721-x6f26ahr 1416 6 gonadal gonadal JJ cord-028721-x6f26ahr 1416 7 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1416 8 : : : cord-028721-x6f26ahr 1416 9 complete complete JJ cord-028721-x6f26ahr 1416 10 and and CC cord-028721-x6f26ahr 1416 11 incomplete incomplete JJ cord-028721-x6f26ahr 1416 12 . . . cord-028721-x6f26ahr 1417 1 Patients patient NNS cord-028721-x6f26ahr 1417 2 with with IN cord-028721-x6f26ahr 1417 3 the the DT cord-028721-x6f26ahr 1417 4 complete complete JJ cord-028721-x6f26ahr 1417 5 type type NN cord-028721-x6f26ahr 1417 6 have have VBP cord-028721-x6f26ahr 1417 7 female female JJ cord-028721-x6f26ahr 1417 8 external external JJ cord-028721-x6f26ahr 1417 9 genitalia genitalia NNS cord-028721-x6f26ahr 1417 10 and and CC cord-028721-x6f26ahr 1417 11 classic classic JJ cord-028721-x6f26ahr 1417 12 streak streak NN cord-028721-x6f26ahr 1417 13 gonads gonad NNS cord-028721-x6f26ahr 1417 14 , , , cord-028721-x6f26ahr 1417 15 although although IN cord-028721-x6f26ahr 1417 16 cases case NNS cord-028721-x6f26ahr 1417 17 with with IN cord-028721-x6f26ahr 1417 18 ovarian ovarian JJ cord-028721-x6f26ahr 1417 19 tissue tissue NN cord-028721-x6f26ahr 1417 20 have have VBP cord-028721-x6f26ahr 1417 21 been be VBN cord-028721-x6f26ahr 1417 22 reported report VBN cord-028721-x6f26ahr 1417 23 . . . cord-028721-x6f26ahr 1418 1 The the DT cord-028721-x6f26ahr 1418 2 cause cause NN cord-028721-x6f26ahr 1418 3 is be VBZ cord-028721-x6f26ahr 1418 4 unknown unknown JJ cord-028721-x6f26ahr 1418 5 in in IN cord-028721-x6f26ahr 1418 6 about about RB cord-028721-x6f26ahr 1418 7 80 80 CD cord-028721-x6f26ahr 1418 8 % % NN cord-028721-x6f26ahr 1418 9 of of IN cord-028721-x6f26ahr 1418 10 cases case NNS cord-028721-x6f26ahr 1418 11 , , , cord-028721-x6f26ahr 1418 12 619 619 CD cord-028721-x6f26ahr 1418 13 and and CC cord-028721-x6f26ahr 1418 14 is be VBZ cord-028721-x6f26ahr 1418 15 due due JJ cord-028721-x6f26ahr 1418 16 to to IN cord-028721-x6f26ahr 1418 17 alterations alteration NNS cord-028721-x6f26ahr 1418 18 in in IN cord-028721-x6f26ahr 1418 19 the the DT cord-028721-x6f26ahr 1418 20 SRY SRY NNP cord-028721-x6f26ahr 1418 21 gene gene NN cord-028721-x6f26ahr 1418 22 in in IN cord-028721-x6f26ahr 1418 23 the the DT cord-028721-x6f26ahr 1418 24 remainder remainder NN cord-028721-x6f26ahr 1418 25 ( ( -LRB- cord-028721-x6f26ahr 1418 26 a a DT cord-028721-x6f26ahr 1418 27 mutation mutation NN cord-028721-x6f26ahr 1418 28 in in IN cord-028721-x6f26ahr 1418 29 10 10 CD cord-028721-x6f26ahr 1418 30 - - SYM cord-028721-x6f26ahr 1418 31 15 15 CD cord-028721-x6f26ahr 1418 32 % % NN cord-028721-x6f26ahr 1418 33 of of IN cord-028721-x6f26ahr 1418 34 cases case NNS cord-028721-x6f26ahr 1418 35 , , , cord-028721-x6f26ahr 1418 36 and and CC cord-028721-x6f26ahr 1418 37 a a DT cord-028721-x6f26ahr 1418 38 SRY SRY NNP cord-028721-x6f26ahr 1418 39 deletion deletion NN cord-028721-x6f26ahr 1418 40 as as IN cord-028721-x6f26ahr 1418 41 a a DT cord-028721-x6f26ahr 1418 42 result result NN cord-028721-x6f26ahr 1418 43 of of IN cord-028721-x6f26ahr 1418 44 an an DT cord-028721-x6f26ahr 1418 45 aberrant aberrant JJ cord-028721-x6f26ahr 1418 46 X x NN cord-028721-x6f26ahr 1418 47 / / SYM cord-028721-x6f26ahr 1418 48 Y Y NNP cord-028721-x6f26ahr 1418 49 interchange interchange NN cord-028721-x6f26ahr 1418 50 in in IN cord-028721-x6f26ahr 1418 51 10 10 CD cord-028721-x6f26ahr 1418 52 - - SYM cord-028721-x6f26ahr 1418 53 15 15 CD cord-028721-x6f26ahr 1418 54 % % NN cord-028721-x6f26ahr 1418 55 ) ) -RRB- cord-028721-x6f26ahr 1418 56 . . . cord-028721-x6f26ahr 1419 1 620 620 CD cord-028721-x6f26ahr 1420 1 The the DT cord-028721-x6f26ahr 1420 2 consequence consequence NN cord-028721-x6f26ahr 1420 3 of of IN cord-028721-x6f26ahr 1420 4 failure failure NN cord-028721-x6f26ahr 1420 5 is be VBZ cord-028721-x6f26ahr 1420 6 very very RB cord-028721-x6f26ahr 1420 7 early early JJ cord-028721-x6f26ahr 1420 8 gonadal gonadal JJ cord-028721-x6f26ahr 1420 9 alteration alteration NN cord-028721-x6f26ahr 1420 10 ( ( -LRB- cord-028721-x6f26ahr 1420 11 sixth sixth JJ cord-028721-x6f26ahr 1420 12 to to IN cord-028721-x6f26ahr 1420 13 eighth eighth JJ cord-028721-x6f26ahr 1420 14 week week NN cord-028721-x6f26ahr 1420 15 of of IN cord-028721-x6f26ahr 1420 16 gestation gestation NN cord-028721-x6f26ahr 1420 17 ) ) -RRB- cord-028721-x6f26ahr 1420 18 . . . cord-028721-x6f26ahr 1421 1 With with IN cord-028721-x6f26ahr 1421 2 the the DT cord-028721-x6f26ahr 1421 3 subsequent subsequent JJ cord-028721-x6f26ahr 1421 4 absence absence NN cord-028721-x6f26ahr 1421 5 of of IN cord-028721-x6f26ahr 1421 6 müllerian müllerian JJ cord-028721-x6f26ahr 1421 7 inhibiting inhibit VBG cord-028721-x6f26ahr 1421 8 factor factor NN cord-028721-x6f26ahr 1421 9 , , , cord-028721-x6f26ahr 1421 10 testosterone testosterone NN cord-028721-x6f26ahr 1421 11 , , , cord-028721-x6f26ahr 1421 12 and and CC cord-028721-x6f26ahr 1421 13 dihydrotestosterone dihydrotestosterone NN cord-028721-x6f26ahr 1421 14 , , , cord-028721-x6f26ahr 1421 15 a a DT cord-028721-x6f26ahr 1421 16 female female JJ cord-028721-x6f26ahr 1421 17 phenotype phenotype NN cord-028721-x6f26ahr 1421 18 develops develop VBZ cord-028721-x6f26ahr 1421 19 . . . cord-028721-x6f26ahr 1422 1 Patients patient NNS cord-028721-x6f26ahr 1422 2 with with IN cord-028721-x6f26ahr 1422 3 incomplete incomplete JJ cord-028721-x6f26ahr 1422 4 46XY 46xy CD cord-028721-x6f26ahr 1422 5 gonadal gonadal JJ cord-028721-x6f26ahr 1422 6 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1422 7 have have VBP cord-028721-x6f26ahr 1422 8 ambiguous ambiguous JJ cord-028721-x6f26ahr 1422 9 external external JJ cord-028721-x6f26ahr 1422 10 genitalia genitalia NNS cord-028721-x6f26ahr 1422 11 and and CC cord-028721-x6f26ahr 1422 12 variable variable JJ cord-028721-x6f26ahr 1422 13 degree degree NN cord-028721-x6f26ahr 1422 14 of of IN cord-028721-x6f26ahr 1422 15 development development NN cord-028721-x6f26ahr 1422 16 of of IN cord-028721-x6f26ahr 1422 17 the the DT cord-028721-x6f26ahr 1422 18 müllerian müllerian JJ cord-028721-x6f26ahr 1422 19 and and CC cord-028721-x6f26ahr 1422 20 wolffi wolffi NNP cord-028721-x6f26ahr 1422 21 an an DT cord-028721-x6f26ahr 1422 22 structures structure NNS cord-028721-x6f26ahr 1422 23 . . . cord-028721-x6f26ahr 1423 1 Although although IN cord-028721-x6f26ahr 1423 2 they -PRON- PRP cord-028721-x6f26ahr 1423 3 have have VBP cord-028721-x6f26ahr 1423 4 streak streak NN cord-028721-x6f26ahr 1423 5 gonads gonad NNS cord-028721-x6f26ahr 1423 6 , , , cord-028721-x6f26ahr 1423 7 testicular testicular JJ cord-028721-x6f26ahr 1423 8 development development NN cord-028721-x6f26ahr 1423 9 is be VBZ cord-028721-x6f26ahr 1423 10 usually usually RB cord-028721-x6f26ahr 1423 11 observed observe VBN cord-028721-x6f26ahr 1423 12 . . . cord-028721-x6f26ahr 1424 1 This this DT cord-028721-x6f26ahr 1424 2 gonadal gonadal JJ cord-028721-x6f26ahr 1424 3 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1424 4 does do VBZ cord-028721-x6f26ahr 1424 5 not not RB cord-028721-x6f26ahr 1424 6 seem seem VB cord-028721-x6f26ahr 1424 7 to to TO cord-028721-x6f26ahr 1424 8 be be VB cord-028721-x6f26ahr 1424 9 caused cause VBN cord-028721-x6f26ahr 1424 10 by by IN cord-028721-x6f26ahr 1424 11 SRY SRY NNP cord-028721-x6f26ahr 1424 12 alterations alteration NNS cord-028721-x6f26ahr 1424 13 . . . cord-028721-x6f26ahr 1425 1 621 621 CD cord-028721-x6f26ahr 1426 1 These these DT cord-028721-x6f26ahr 1426 2 fi fi NN cord-028721-x6f26ahr 1426 3 ndings nding NNS cord-028721-x6f26ahr 1426 4 suggest suggest VBP cord-028721-x6f26ahr 1426 5 that that IN cord-028721-x6f26ahr 1426 6 in in IN cord-028721-x6f26ahr 1426 7 the the DT cord-028721-x6f26ahr 1426 8 fi fi NN cord-028721-x6f26ahr 1426 9 rst rst NN cord-028721-x6f26ahr 1426 10 type type NN cord-028721-x6f26ahr 1426 11 ovarian ovarian JJ cord-028721-x6f26ahr 1426 12 differentiation differentiation NN cord-028721-x6f26ahr 1426 13 was be VBD cord-028721-x6f26ahr 1426 14 canceled cancel VBN cord-028721-x6f26ahr 1426 15 , , , cord-028721-x6f26ahr 1426 16 and and CC cord-028721-x6f26ahr 1426 17 that that IN cord-028721-x6f26ahr 1426 18 in in IN cord-028721-x6f26ahr 1426 19 the the DT cord-028721-x6f26ahr 1426 20 second second JJ cord-028721-x6f26ahr 1426 21 type type NN cord-028721-x6f26ahr 1426 22 testicular testicular JJ cord-028721-x6f26ahr 1426 23 differentiation differentiation NN cord-028721-x6f26ahr 1426 24 failed fail VBD cord-028721-x6f26ahr 1426 25 . . . cord-028721-x6f26ahr 1427 1 The the DT cord-028721-x6f26ahr 1427 2 fi fi NN cord-028721-x6f26ahr 1427 3 rst rst NNP cord-028721-x6f26ahr 1427 4 is be VBZ cord-028721-x6f26ahr 1427 5 similar similar JJ cord-028721-x6f26ahr 1427 6 to to IN cord-028721-x6f26ahr 1427 7 the the DT cord-028721-x6f26ahr 1427 8 gonad gonad NN cord-028721-x6f26ahr 1427 9 of of IN cord-028721-x6f26ahr 1427 10 45X0 45x0 CD cord-028721-x6f26ahr 1427 11 Turner Turner NNP cord-028721-x6f26ahr 1427 12 's 's POS cord-028721-x6f26ahr 1427 13 syndrome syndrome NN cord-028721-x6f26ahr 1427 14 , , , cord-028721-x6f26ahr 1427 15 whereas whereas IN cord-028721-x6f26ahr 1427 16 the the DT cord-028721-x6f26ahr 1427 17 second second JJ cord-028721-x6f26ahr 1427 18 resembles resemble VBZ cord-028721-x6f26ahr 1427 19 the the DT cord-028721-x6f26ahr 1427 20 gonad gonad NN cord-028721-x6f26ahr 1427 21 of of IN cord-028721-x6f26ahr 1427 22 mixed mixed JJ cord-028721-x6f26ahr 1427 23 gonadal gonadal JJ cord-028721-x6f26ahr 1427 24 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1427 25 . . . cord-028721-x6f26ahr 1428 1 622 622 CD cord-028721-x6f26ahr 1429 1 The the DT cord-028721-x6f26ahr 1429 2 clitoromegaly clitoromegaly NNS cord-028721-x6f26ahr 1429 3 may may MD cord-028721-x6f26ahr 1429 4 be be VB cord-028721-x6f26ahr 1429 5 caused cause VBN cord-028721-x6f26ahr 1429 6 by by IN cord-028721-x6f26ahr 1429 7 androgens androgen NNS cord-028721-x6f26ahr 1429 8 secreted secrete VBN cord-028721-x6f26ahr 1429 9 by by IN cord-028721-x6f26ahr 1429 10 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 1429 11 Leydig Leydig NNP cord-028721-x6f26ahr 1429 12 cells cell NNS cord-028721-x6f26ahr 1429 13 in in IN cord-028721-x6f26ahr 1429 14 the the DT cord-028721-x6f26ahr 1429 15 streak streak NN cord-028721-x6f26ahr 1429 16 gonad gonad NN cord-028721-x6f26ahr 1429 17 . . . cord-028721-x6f26ahr 1430 1 Some some DT cord-028721-x6f26ahr 1430 2 patients patient NNS cord-028721-x6f26ahr 1430 3 with with IN cord-028721-x6f26ahr 1430 4 46XY 46xy CD cord-028721-x6f26ahr 1430 5 gonadal gonadal JJ cord-028721-x6f26ahr 1430 6 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1430 7 present present JJ cord-028721-x6f26ahr 1430 8 with with IN cord-028721-x6f26ahr 1430 9 extragonadal extragonadal JJ cord-028721-x6f26ahr 1430 10 anomalies anomaly NNS cord-028721-x6f26ahr 1430 11 and and CC cord-028721-x6f26ahr 1430 12 multiple multiple JJ cord-028721-x6f26ahr 1430 13 syndromes syndrome NNS cord-028721-x6f26ahr 1430 14 , , , cord-028721-x6f26ahr 1430 15 including include VBG cord-028721-x6f26ahr 1430 16 camptomelic camptomelic JJ cord-028721-x6f26ahr 1430 17 dysplasia dysplasia NN cord-028721-x6f26ahr 1430 18 and and CC cord-028721-x6f26ahr 1430 19 renal renal JJ cord-028721-x6f26ahr 1430 20 disorder disorder NN cord-028721-x6f26ahr 1430 21 , , , cord-028721-x6f26ahr 1430 22 623 623 CD cord-028721-x6f26ahr 1430 23 myotonic myotonic JJ cord-028721-x6f26ahr 1430 24 dystrophy dystrophy NN cord-028721-x6f26ahr 1430 25 and and CC cord-028721-x6f26ahr 1430 26 terminal terminal JJ cord-028721-x6f26ahr 1430 27 renal renal JJ cord-028721-x6f26ahr 1430 28 disease disease NN cord-028721-x6f26ahr 1430 29 , , , cord-028721-x6f26ahr 1430 30 624 624 CD cord-028721-x6f26ahr 1430 31 without without IN cord-028721-x6f26ahr 1430 32 631 631 CD cord-028721-x6f26ahr 1430 33 facial facial JJ cord-028721-x6f26ahr 1430 34 anomalies anomaly NNS cord-028721-x6f26ahr 1430 35 or or CC cord-028721-x6f26ahr 1430 36 short short JJ cord-028721-x6f26ahr 1430 37 stature stature NN cord-028721-x6f26ahr 1430 38 , , , cord-028721-x6f26ahr 1430 39 632 632 CD cord-028721-x6f26ahr 1430 40 renal renal JJ cord-028721-x6f26ahr 1430 41 insufficiency insufficiency NN cord-028721-x6f26ahr 1430 42 and and CC cord-028721-x6f26ahr 1430 43 Wilms Wilms NNP cord-028721-x6f26ahr 1430 44 ' ' POS cord-028721-x6f26ahr 1430 45 tumor tumor NN cord-028721-x6f26ahr 1430 46 ( ( -LRB- cord-028721-x6f26ahr 1430 47 Denys Denys NNP cord-028721-x6f26ahr 1430 48 - - HYPH cord-028721-x6f26ahr 1430 49 Drash Drash NNP cord-028721-x6f26ahr 1430 50 syndrome syndrome NN cord-028721-x6f26ahr 1430 51 ) ) -RRB- cord-028721-x6f26ahr 1430 52 , , , cord-028721-x6f26ahr 1430 53 the the DT cord-028721-x6f26ahr 1430 54 combination combination NN cord-028721-x6f26ahr 1430 55 of of IN cord-028721-x6f26ahr 1430 56 cleft cleft NN cord-028721-x6f26ahr 1430 57 palate palate NN cord-028721-x6f26ahr 1430 58 , , , cord-028721-x6f26ahr 1430 59 micrognathia micrognathia NNP cord-028721-x6f26ahr 1430 60 , , , cord-028721-x6f26ahr 1430 61 kyphosis kyphosis NN cord-028721-x6f26ahr 1430 62 , , , cord-028721-x6f26ahr 1430 63 scoliosis scoliosis NN cord-028721-x6f26ahr 1430 64 , , , cord-028721-x6f26ahr 1430 65 and and CC cord-028721-x6f26ahr 1430 66 clubfoot clubfoot NN cord-028721-x6f26ahr 1430 67 ( ( -LRB- cord-028721-x6f26ahr 1430 68 Gardner Gardner NNP cord-028721-x6f26ahr 1430 69 - - HYPH cord-028721-x6f26ahr 1430 70 Silengo Silengo NNP cord-028721-x6f26ahr 1430 71 - - HYPH cord-028721-x6f26ahr 1430 72 Wachtel Wachtel NNP cord-028721-x6f26ahr 1430 73 syndrome syndrome NN cord-028721-x6f26ahr 1430 74 or or CC cord-028721-x6f26ahr 1430 75 genitopalatocardiac genitopalatocardiac NNP cord-028721-x6f26ahr 1430 76 syndrome syndrome NNP cord-028721-x6f26ahr 1430 77 ) ) -RRB- cord-028721-x6f26ahr 1430 78 , , , cord-028721-x6f26ahr 1430 79 633 633 CD cord-028721-x6f26ahr 1430 80 pterygium pterygium NN cord-028721-x6f26ahr 1430 81 multiple multiple JJ cord-028721-x6f26ahr 1430 82 syndrome syndrome NN cord-028721-x6f26ahr 1430 83 , , , cord-028721-x6f26ahr 1430 84 634 634 CD cord-028721-x6f26ahr 1430 85 Graves Graves NNPS cord-028721-x6f26ahr 1430 86 ' ' POS cord-028721-x6f26ahr 1430 87 disease disease NN cord-028721-x6f26ahr 1430 88 , , , cord-028721-x6f26ahr 1430 89 635 635 CD cord-028721-x6f26ahr 1430 90 , , , cord-028721-x6f26ahr 1430 91 636 636 CD cord-028721-x6f26ahr 1430 92 and and CC cord-028721-x6f26ahr 1430 93 congenital congenital JJ cord-028721-x6f26ahr 1430 94 universalis universalis NN cord-028721-x6f26ahr 1430 95 alopecia alopecia NN cord-028721-x6f26ahr 1430 96 , , , cord-028721-x6f26ahr 1430 97 microcephaly microcephaly NNS cord-028721-x6f26ahr 1430 98 , , , cord-028721-x6f26ahr 1430 99 cutis cutis NNP cord-028721-x6f26ahr 1430 100 marmorata marmorata NNP cord-028721-x6f26ahr 1430 101 , , , cord-028721-x6f26ahr 1430 102 and and CC cord-028721-x6f26ahr 1430 103 short short JJ cord-028721-x6f26ahr 1430 104 stature stature NN cord-028721-x6f26ahr 1430 105 . . . cord-028721-x6f26ahr 1431 1 637 637 CD cord-028721-x6f26ahr 1431 2 , , , cord-028721-x6f26ahr 1431 3 638 638 CD cord-028721-x6f26ahr 1431 4 Most Most JJS cord-028721-x6f26ahr 1431 5 cases case NNS cord-028721-x6f26ahr 1431 6 are be VBP cord-028721-x6f26ahr 1431 7 sporadic sporadic JJ cord-028721-x6f26ahr 1431 8 , , , cord-028721-x6f26ahr 1431 9 639 639 CD cord-028721-x6f26ahr 1431 10 although although IN cord-028721-x6f26ahr 1431 11 the the DT cord-028721-x6f26ahr 1431 12 syndrome syndrome NN cord-028721-x6f26ahr 1431 13 has have VBZ cord-028721-x6f26ahr 1431 14 been be VBN cord-028721-x6f26ahr 1431 15 reported report VBN cord-028721-x6f26ahr 1431 16 in in IN cord-028721-x6f26ahr 1431 17 several several JJ cord-028721-x6f26ahr 1431 18 members member NNS cord-028721-x6f26ahr 1431 19 of of IN cord-028721-x6f26ahr 1431 20 the the DT cord-028721-x6f26ahr 1431 21 same same JJ cord-028721-x6f26ahr 1431 22 family family NN cord-028721-x6f26ahr 1431 23 , , , cord-028721-x6f26ahr 1431 24 [ [ -LRB- cord-028721-x6f26ahr 1431 25 640 640 CD cord-028721-x6f26ahr 1431 26 ] ] -RRB- cord-028721-x6f26ahr 1432 1 [ [ -LRB- cord-028721-x6f26ahr 1432 2 641 641 CD cord-028721-x6f26ahr 1432 3 ] ] -RRB- cord-028721-x6f26ahr 1432 4 [ [ -LRB- cord-028721-x6f26ahr 1432 5 642 642 CD cord-028721-x6f26ahr 1432 6 ] ] -RRB- cord-028721-x6f26ahr 1432 7 [ [ -LRB- cord-028721-x6f26ahr 1432 8 643 643 CD cord-028721-x6f26ahr 1432 9 ] ] -RRB- cord-028721-x6f26ahr 1432 10 and and CC cord-028721-x6f26ahr 1432 11 several several JJ cord-028721-x6f26ahr 1432 12 forms form NNS cord-028721-x6f26ahr 1432 13 of of IN cord-028721-x6f26ahr 1432 14 inheritance inheritance NN cord-028721-x6f26ahr 1433 1 ( ( -LRB- cord-028721-x6f26ahr 1433 2 X x NN cord-028721-x6f26ahr 1433 3 - - HYPH cord-028721-x6f26ahr 1433 4 linked link VBN cord-028721-x6f26ahr 1433 5 , , , cord-028721-x6f26ahr 1433 6 autosomal autosomal JJ cord-028721-x6f26ahr 1433 7 recessive recessive JJ cord-028721-x6f26ahr 1433 8 , , , cord-028721-x6f26ahr 1433 9 and and CC cord-028721-x6f26ahr 1433 10 male male NN cord-028721-x6f26ahr 1433 11 - - HYPH cord-028721-x6f26ahr 1433 12 limited limit VBN cord-028721-x6f26ahr 1433 13 autosomal autosomal JJ cord-028721-x6f26ahr 1433 14 dominant dominant NN cord-028721-x6f26ahr 1433 15 ) ) -RRB- cord-028721-x6f26ahr 1433 16 have have VBP cord-028721-x6f26ahr 1433 17 been be VBN cord-028721-x6f26ahr 1433 18 proposed propose VBN cord-028721-x6f26ahr 1433 19 . . . cord-028721-x6f26ahr 1434 1 644 644 CD cord-028721-x6f26ahr 1435 1 In in IN cord-028721-x6f26ahr 1435 2 addition addition NN cord-028721-x6f26ahr 1435 3 to to IN cord-028721-x6f26ahr 1435 4 infertility infertility NN cord-028721-x6f26ahr 1435 5 , , , cord-028721-x6f26ahr 1435 6 patients patient NNS cord-028721-x6f26ahr 1435 7 with with IN cord-028721-x6f26ahr 1435 8 46XY 46xy CD cord-028721-x6f26ahr 1435 9 gonadal gonadal JJ cord-028721-x6f26ahr 1435 10 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1435 11 have have VBP cord-028721-x6f26ahr 1435 12 a a DT cord-028721-x6f26ahr 1435 13 high high JJ cord-028721-x6f26ahr 1435 14 risk risk NN cord-028721-x6f26ahr 1435 15 of of IN cord-028721-x6f26ahr 1435 16 germ germ NN cord-028721-x6f26ahr 1435 17 cell cell NN cord-028721-x6f26ahr 1435 18 tumor tumor NN cord-028721-x6f26ahr 1435 19 . . . cord-028721-x6f26ahr 1436 1 This this DT cord-028721-x6f26ahr 1436 2 risk risk NN cord-028721-x6f26ahr 1436 3 is be VBZ cord-028721-x6f26ahr 1436 4 about about RB cord-028721-x6f26ahr 1436 5 5 5 CD cord-028721-x6f26ahr 1436 6 % % NN cord-028721-x6f26ahr 1436 7 in in IN cord-028721-x6f26ahr 1436 8 the the DT cord-028721-x6f26ahr 1436 9 fi fi NN cord-028721-x6f26ahr 1436 10 rst rst NN cord-028721-x6f26ahr 1436 11 decade decade NN cord-028721-x6f26ahr 1436 12 of of IN cord-028721-x6f26ahr 1436 13 life life NN cord-028721-x6f26ahr 1436 14 , , , cord-028721-x6f26ahr 1436 15 and and CC cord-028721-x6f26ahr 1436 16 25 25 CD cord-028721-x6f26ahr 1436 17 - - SYM cord-028721-x6f26ahr 1436 18 30 30 CD cord-028721-x6f26ahr 1436 19 % % NN cord-028721-x6f26ahr 1436 20 overall overall JJ cord-028721-x6f26ahr 1436 21 , , , cord-028721-x6f26ahr 1436 22 [ [ -LRB- cord-028721-x6f26ahr 1436 23 645 645 CD cord-028721-x6f26ahr 1436 24 ] ] -RRB- cord-028721-x6f26ahr 1436 25 [ [ -LRB- cord-028721-x6f26ahr 1436 26 646 646 CD cord-028721-x6f26ahr 1436 27 ] ] -RRB- cord-028721-x6f26ahr 1436 28 [ [ -LRB- cord-028721-x6f26ahr 1436 29 647 647 CD cord-028721-x6f26ahr 1436 30 ] ] -RRB- cord-028721-x6f26ahr 1437 1 [ [ -LRB- cord-028721-x6f26ahr 1437 2 648 648 CD cord-028721-x6f26ahr 1437 3 ] ] -RRB- cord-028721-x6f26ahr 1437 4 and and CC cord-028721-x6f26ahr 1437 5 , , , cord-028721-x6f26ahr 1437 6 thus thus RB cord-028721-x6f26ahr 1437 7 , , , cord-028721-x6f26ahr 1437 8 prophylactic prophylactic JJ cord-028721-x6f26ahr 1437 9 gonadectomy gonadectomy NN cord-028721-x6f26ahr 1437 10 is be VBZ cord-028721-x6f26ahr 1437 11 recommended recommend VBN cord-028721-x6f26ahr 1437 12 . . . cord-028721-x6f26ahr 1438 1 Patients patient NNS cord-028721-x6f26ahr 1438 2 with with IN cord-028721-x6f26ahr 1438 3 46XX 46xx CD cord-028721-x6f26ahr 1438 4 gonadal gonadal NN cord-028721-x6f26ahr 1438 5 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1438 6 have have VBP cord-028721-x6f26ahr 1438 7 normal normal JJ cord-028721-x6f26ahr 1438 8 stature stature NN cord-028721-x6f26ahr 1438 9 , , , cord-028721-x6f26ahr 1438 10 female female JJ cord-028721-x6f26ahr 1438 11 phenotype phenotype NN cord-028721-x6f26ahr 1438 12 , , , cord-028721-x6f26ahr 1438 13 well well RB cord-028721-x6f26ahr 1438 14 - - HYPH cord-028721-x6f26ahr 1438 15 developed develop VBN cord-028721-x6f26ahr 1438 16 external external JJ cord-028721-x6f26ahr 1438 17 genitalia genitalia NNS cord-028721-x6f26ahr 1438 18 , , , cord-028721-x6f26ahr 1438 19 and and CC cord-028721-x6f26ahr 1438 20 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1438 21 ovaries ovary NNS cord-028721-x6f26ahr 1438 22 rather rather RB cord-028721-x6f26ahr 1438 23 than than IN cord-028721-x6f26ahr 1438 24 streak streak NN cord-028721-x6f26ahr 1438 25 gonads gonad NNS cord-028721-x6f26ahr 1438 26 ( ( -LRB- cord-028721-x6f26ahr 1438 27 Fig Fig NNP cord-028721-x6f26ahr 1438 28 . . . cord-028721-x6f26ahr 1438 29 12 12 CD cord-028721-x6f26ahr 1438 30 - - SYM cord-028721-x6f26ahr 1438 31 65 65 CD cord-028721-x6f26ahr 1438 32 ) ) -RRB- cord-028721-x6f26ahr 1438 33 . . . cord-028721-x6f26ahr 1439 1 The the DT cord-028721-x6f26ahr 1439 2 anomaly anomaly NN cord-028721-x6f26ahr 1439 3 is be VBZ cord-028721-x6f26ahr 1439 4 usually usually RB cord-028721-x6f26ahr 1439 5 detected detect VBN cord-028721-x6f26ahr 1439 6 when when WRB cord-028721-x6f26ahr 1439 7 patients patient NNS cord-028721-x6f26ahr 1439 8 present present JJ cord-028721-x6f26ahr 1439 9 with with IN cord-028721-x6f26ahr 1439 10 primary primary JJ cord-028721-x6f26ahr 1439 11 amenorrhea amenorrhea NN cord-028721-x6f26ahr 1439 12 or or CC cord-028721-x6f26ahr 1439 13 infertility infertility NN cord-028721-x6f26ahr 1439 14 . . . cord-028721-x6f26ahr 1440 1 This this DT cord-028721-x6f26ahr 1440 2 syndrome syndrome NN cord-028721-x6f26ahr 1440 3 is be VBZ cord-028721-x6f26ahr 1440 4 sporadic sporadic JJ cord-028721-x6f26ahr 1440 5 and and CC cord-028721-x6f26ahr 1440 6 familial familial JJ cord-028721-x6f26ahr 1440 7 , , , cord-028721-x6f26ahr 1440 8 and and CC cord-028721-x6f26ahr 1440 9 it -PRON- PRP cord-028721-x6f26ahr 1440 10 may may MD cord-028721-x6f26ahr 1440 11 be be VB cord-028721-x6f26ahr 1440 12 linked link VBN cord-028721-x6f26ahr 1440 13 to to IN cord-028721-x6f26ahr 1440 14 recessive recessive JJ cord-028721-x6f26ahr 1440 15 autosomal autosomal JJ cord-028721-x6f26ahr 1440 16 inheritance inheritance NN cord-028721-x6f26ahr 1440 17 . . . cord-028721-x6f26ahr 1441 1 649 649 CD cord-028721-x6f26ahr 1441 2 , , , cord-028721-x6f26ahr 1441 3 650 650 CD cord-028721-x6f26ahr 1441 4 Patients patient NNS cord-028721-x6f26ahr 1441 5 have have VBP cord-028721-x6f26ahr 1441 6 no no DT cord-028721-x6f26ahr 1441 7 predisposition predisposition NN cord-028721-x6f26ahr 1441 8 to to IN cord-028721-x6f26ahr 1441 9 gonadal gonadal JJ cord-028721-x6f26ahr 1441 10 neoplasia neoplasia NN cord-028721-x6f26ahr 1441 11 . . . cord-028721-x6f26ahr 1442 1 Associated associated JJ cord-028721-x6f26ahr 1442 2 somatic somatic JJ cord-028721-x6f26ahr 1442 3 anomalies anomaly NNS cord-028721-x6f26ahr 1442 4 such such JJ cord-028721-x6f26ahr 1442 5 as as IN cord-028721-x6f26ahr 1442 6 neurosensory neurosensory NN cord-028721-x6f26ahr 1442 7 hearing hear VBG cord-028721-x6f26ahr 1442 8 loss loss NN cord-028721-x6f26ahr 1442 9 ( ( -LRB- cord-028721-x6f26ahr 1442 10 Perrault Perrault NNP cord-028721-x6f26ahr 1442 11 's 's POS cord-028721-x6f26ahr 1442 12 syndrome syndrome NN cord-028721-x6f26ahr 1442 13 ) ) -RRB- cord-028721-x6f26ahr 1442 14 are be VBP cord-028721-x6f26ahr 1442 15 rare rare JJ cord-028721-x6f26ahr 1442 16 . . . cord-028721-x6f26ahr 1443 1 Some some DT cord-028721-x6f26ahr 1443 2 familial familial JJ cord-028721-x6f26ahr 1443 3 cases case NNS cord-028721-x6f26ahr 1443 4 have have VBP cord-028721-x6f26ahr 1443 5 shown show VBN cord-028721-x6f26ahr 1443 6 a a DT cord-028721-x6f26ahr 1443 7 balanced balanced JJ cord-028721-x6f26ahr 1443 8 translocation translocation NN cord-028721-x6f26ahr 1443 9 of of IN cord-028721-x6f26ahr 1443 10 the the DT cord-028721-x6f26ahr 1443 11 X x NN cord-028721-x6f26ahr 1443 12 chromosome chromosome NN cord-028721-x6f26ahr 1443 13 ( ( -LRB- cord-028721-x6f26ahr 1443 14 from from IN cord-028721-x6f26ahr 1443 15 the the DT cord-028721-x6f26ahr 1443 16 long long JJ cord-028721-x6f26ahr 1443 17 arm arm NN cord-028721-x6f26ahr 1443 18 to to IN cord-028721-x6f26ahr 1443 19 the the DT cord-028721-x6f26ahr 1443 20 short short JJ cord-028721-x6f26ahr 1443 21 arm arm NN cord-028721-x6f26ahr 1443 22 ) ) -RRB- cord-028721-x6f26ahr 1443 23 651 651 CD cord-028721-x6f26ahr 1443 24 , , , cord-028721-x6f26ahr 1443 25 652 652 CD cord-028721-x6f26ahr 1443 26 or or CC cord-028721-x6f26ahr 1443 27 between between IN cord-028721-x6f26ahr 1443 28 chromosomes chromosome NNS cord-028721-x6f26ahr 1443 29 1 1 CD cord-028721-x6f26ahr 1443 30 and and CC cord-028721-x6f26ahr 1443 31 11 11 CD cord-028721-x6f26ahr 1443 32 . . . cord-028721-x6f26ahr 1444 1 653 653 CD cord-028721-x6f26ahr 1445 1 Because because IN cord-028721-x6f26ahr 1445 2 the the DT cord-028721-x6f26ahr 1445 3 development development NN cord-028721-x6f26ahr 1445 4 of of IN cord-028721-x6f26ahr 1445 5 ovarian ovarian JJ cord-028721-x6f26ahr 1445 6 follicles follicle NNS cord-028721-x6f26ahr 1445 7 requires require VBZ cord-028721-x6f26ahr 1445 8 FSH fsh NN cord-028721-x6f26ahr 1445 9 , , , cord-028721-x6f26ahr 1445 10 mutations mutation NNS cord-028721-x6f26ahr 1445 11 have have VBP cord-028721-x6f26ahr 1445 12 been be VBN cord-028721-x6f26ahr 1445 13 sought seek VBN cord-028721-x6f26ahr 1445 14 in in IN cord-028721-x6f26ahr 1445 15 the the DT cord-028721-x6f26ahr 1445 16 FSHR FSHR NNP cord-028721-x6f26ahr 1445 17 gene gene NN cord-028721-x6f26ahr 1445 18 . . . cord-028721-x6f26ahr 1446 1 Mutations mutation NNS cord-028721-x6f26ahr 1446 2 have have VBP cord-028721-x6f26ahr 1446 3 been be VBN cord-028721-x6f26ahr 1446 4 detected detect VBN cord-028721-x6f26ahr 1446 5 in in IN cord-028721-x6f26ahr 1446 6 familial familial JJ cord-028721-x6f26ahr 1446 7 cases case NNS cord-028721-x6f26ahr 1446 8 and and CC cord-028721-x6f26ahr 1446 9 also also RB cord-028721-x6f26ahr 1446 10 in in IN cord-028721-x6f26ahr 1446 11 unrelated unrelated JJ cord-028721-x6f26ahr 1446 12 patients patient NNS cord-028721-x6f26ahr 1446 13 , , , cord-028721-x6f26ahr 1446 14 654 654 CD cord-028721-x6f26ahr 1446 15 , , , cord-028721-x6f26ahr 1446 16 655 655 CD cord-028721-x6f26ahr 1446 17 whereas whereas IN cord-028721-x6f26ahr 1446 18 other other JJ cord-028721-x6f26ahr 1446 19 patients patient NNS cord-028721-x6f26ahr 1446 20 have have VBP cord-028721-x6f26ahr 1446 21 shown show VBN cord-028721-x6f26ahr 1446 22 no no DT cord-028721-x6f26ahr 1446 23 mutations mutation NNS cord-028721-x6f26ahr 1446 24 in in IN cord-028721-x6f26ahr 1446 25 this this DT cord-028721-x6f26ahr 1446 26 gene gene NN cord-028721-x6f26ahr 1446 27 . . . cord-028721-x6f26ahr 1447 1 656 656 CD cord-028721-x6f26ahr 1448 1 The the DT cord-028721-x6f26ahr 1448 2 incidence incidence NN cord-028721-x6f26ahr 1448 3 of of IN cord-028721-x6f26ahr 1448 4 tumors tumor NNS cord-028721-x6f26ahr 1448 5 in in IN cord-028721-x6f26ahr 1448 6 these these DT cord-028721-x6f26ahr 1448 7 patients patient NNS cord-028721-x6f26ahr 1448 8 is be VBZ cord-028721-x6f26ahr 1448 9 very very RB cord-028721-x6f26ahr 1448 10 low low JJ cord-028721-x6f26ahr 1448 11 , , , cord-028721-x6f26ahr 1448 12 and and CC cord-028721-x6f26ahr 1448 13 the the DT cord-028721-x6f26ahr 1448 14 most most RBS cord-028721-x6f26ahr 1448 15 common common JJ cord-028721-x6f26ahr 1448 16 is be VBZ cord-028721-x6f26ahr 1448 17 dysgerminoma dysgerminoma NNP cord-028721-x6f26ahr 1448 18 . . . cord-028721-x6f26ahr 1449 1 [ [ -LRB- cord-028721-x6f26ahr 1449 2 657 657 CD cord-028721-x6f26ahr 1449 3 ] ] -RRB- cord-028721-x6f26ahr 1449 4 [ [ -LRB- cord-028721-x6f26ahr 1449 5 658 658 CD cord-028721-x6f26ahr 1449 6 ] ] -RRB- cord-028721-x6f26ahr 1449 7 [ [ -LRB- cord-028721-x6f26ahr 1449 8 659 659 CD cord-028721-x6f26ahr 1449 9 ] ] -RRB- cord-028721-x6f26ahr 1449 10 _SP cord-028721-x6f26ahr 1450 1 This this DT cord-028721-x6f26ahr 1450 2 is be VBZ cord-028721-x6f26ahr 1450 3 one one CD cord-028721-x6f26ahr 1450 4 of of IN cord-028721-x6f26ahr 1450 5 the the DT cord-028721-x6f26ahr 1450 6 most most RBS cord-028721-x6f26ahr 1450 7 common common JJ cord-028721-x6f26ahr 1450 8 chromosomal chromosomal JJ cord-028721-x6f26ahr 1450 9 anomalies anomaly NNS cord-028721-x6f26ahr 1450 10 ( ( -LRB- cord-028721-x6f26ahr 1450 11 from from IN cord-028721-x6f26ahr 1450 12 1/2500 1/2500 CD cord-028721-x6f26ahr 1450 13 to to IN cord-028721-x6f26ahr 1450 14 1/5000 1/5000 CD cord-028721-x6f26ahr 1450 15 in in IN cord-028721-x6f26ahr 1450 16 female female JJ cord-028721-x6f26ahr 1450 17 newborns newborn NNS cord-028721-x6f26ahr 1450 18 ) ) -RRB- cord-028721-x6f26ahr 1450 19 , , , cord-028721-x6f26ahr 1450 20 660 660 CD cord-028721-x6f26ahr 1450 21 although although IN cord-028721-x6f26ahr 1450 22 99 99 CD cord-028721-x6f26ahr 1450 23 % % NN cord-028721-x6f26ahr 1450 24 of of IN cord-028721-x6f26ahr 1450 25 zygotes zygote NNS cord-028721-x6f26ahr 1450 26 with with IN cord-028721-x6f26ahr 1450 27 this this DT cord-028721-x6f26ahr 1450 28 karyotype karyotype NN cord-028721-x6f26ahr 1450 29 are be VBP cord-028721-x6f26ahr 1450 30 aborted abort VBN cord-028721-x6f26ahr 1450 31 in in IN cord-028721-x6f26ahr 1450 32 the the DT cord-028721-x6f26ahr 1450 33 fi fi NN cord-028721-x6f26ahr 1450 34 rst rst NN cord-028721-x6f26ahr 1450 35 stages stage NNS cord-028721-x6f26ahr 1450 36 of of IN cord-028721-x6f26ahr 1450 37 embryonal embryonal JJ cord-028721-x6f26ahr 1450 38 development development NN cord-028721-x6f26ahr 1450 39 . . . cord-028721-x6f26ahr 1451 1 661 661 CD cord-028721-x6f26ahr 1451 2 Patients patient NNS cord-028721-x6f26ahr 1451 3 with with IN cord-028721-x6f26ahr 1451 4 45XO 45xo CD cord-028721-x6f26ahr 1451 5 gonadal gonadal JJ cord-028721-x6f26ahr 1451 6 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1451 7 have have VBP cord-028721-x6f26ahr 1451 8 characteristic characteristic JJ cord-028721-x6f26ahr 1451 9 stigmata stigmata NN cord-028721-x6f26ahr 1451 10 of of IN cord-028721-x6f26ahr 1451 11 Turner Turner NNP cord-028721-x6f26ahr 1451 12 's 's POS cord-028721-x6f26ahr 1451 13 syndrome syndrome NN cord-028721-x6f26ahr 1451 14 , , , cord-028721-x6f26ahr 1451 15 including include VBG cord-028721-x6f26ahr 1451 16 short short JJ cord-028721-x6f26ahr 1451 17 stature stature NN cord-028721-x6f26ahr 1451 18 , , , cord-028721-x6f26ahr 1451 19 pterygium pterygium NN cord-028721-x6f26ahr 1451 20 coli coli NNS cord-028721-x6f26ahr 1451 21 , , , cord-028721-x6f26ahr 1451 22 lymphedema lymphedema NN cord-028721-x6f26ahr 1451 23 , , , cord-028721-x6f26ahr 1451 24 and and CC cord-028721-x6f26ahr 1451 25 cardiac cardiac JJ cord-028721-x6f26ahr 1451 26 malformations malformation NNS cord-028721-x6f26ahr 1451 27 . . . cord-028721-x6f26ahr 1452 1 The the DT cord-028721-x6f26ahr 1452 2 external external JJ cord-028721-x6f26ahr 1452 3 genitalia genitalia NNS cord-028721-x6f26ahr 1452 4 are be VBP cord-028721-x6f26ahr 1452 5 female female JJ cord-028721-x6f26ahr 1452 6 and and CC cord-028721-x6f26ahr 1452 7 infantile infantile JJ cord-028721-x6f26ahr 1452 8 ; ; : cord-028721-x6f26ahr 1452 9 the the DT cord-028721-x6f26ahr 1452 10 gonads gonad NNS cord-028721-x6f26ahr 1452 11 are be VBP cord-028721-x6f26ahr 1452 12 typical typical JJ cord-028721-x6f26ahr 1452 13 streak streak NN cord-028721-x6f26ahr 1452 14 gonads gonad NNS cord-028721-x6f26ahr 1452 15 . . . cord-028721-x6f26ahr 1453 1 Today today NN cord-028721-x6f26ahr 1453 2 , , , cord-028721-x6f26ahr 1453 3 Turner Turner NNP cord-028721-x6f26ahr 1453 4 's 's POS cord-028721-x6f26ahr 1453 5 syndrome syndrome NN cord-028721-x6f26ahr 1453 6 is be VBZ cord-028721-x6f26ahr 1453 7 defi defi NNP cord-028721-x6f26ahr 1453 8 ned ned NNP cord-028721-x6f26ahr 1453 9 by by IN cord-028721-x6f26ahr 1453 10 the the DT cord-028721-x6f26ahr 1453 11 combination combination NN cord-028721-x6f26ahr 1453 12 of of IN cord-028721-x6f26ahr 1453 13 physical physical JJ cord-028721-x6f26ahr 1453 14 features feature NNS cord-028721-x6f26ahr 1453 15 and and CC cord-028721-x6f26ahr 1453 16 the the DT cord-028721-x6f26ahr 1453 17 complete complete JJ cord-028721-x6f26ahr 1453 18 or or CC cord-028721-x6f26ahr 1453 19 partial partial JJ cord-028721-x6f26ahr 1453 20 absence absence NN cord-028721-x6f26ahr 1453 21 of of IN cord-028721-x6f26ahr 1453 22 one one CD cord-028721-x6f26ahr 1453 23 of of IN cord-028721-x6f26ahr 1453 24 both both CC cord-028721-x6f26ahr 1453 25 X x NN cord-028721-x6f26ahr 1453 26 chromosomes chromosome NNS cord-028721-x6f26ahr 1453 27 , , , cord-028721-x6f26ahr 1453 28 frequently frequently RB cord-028721-x6f26ahr 1453 29 associated associate VBN cord-028721-x6f26ahr 1453 30 with with IN cord-028721-x6f26ahr 1453 31 mosaicism mosaicism NN cord-028721-x6f26ahr 1453 32 . . . cord-028721-x6f26ahr 1454 1 Turnerian turnerian JJ cord-028721-x6f26ahr 1454 2 stigmata stigmata NN cord-028721-x6f26ahr 1454 3 may may MD cord-028721-x6f26ahr 1454 4 be be VB cord-028721-x6f26ahr 1454 5 classifi classifi NNP cord-028721-x6f26ahr 1454 6 ed ed NNP cord-028721-x6f26ahr 1454 7 into into IN cord-028721-x6f26ahr 1454 8 four four CD cord-028721-x6f26ahr 1454 9 groups group NNS cord-028721-x6f26ahr 1454 10 : : : cord-028721-x6f26ahr 1454 11 662 662 CD cord-028721-x6f26ahr 1454 12 skeletal skeletal JJ cord-028721-x6f26ahr 1454 13 anomalies anomaly NNS cord-028721-x6f26ahr 1454 14 such such JJ cord-028721-x6f26ahr 1454 15 as as IN cord-028721-x6f26ahr 1454 16 cubitus cubitus NN cord-028721-x6f26ahr 1454 17 valgus valgus NNP cord-028721-x6f26ahr 1454 18 , , , cord-028721-x6f26ahr 1454 19 shortening shortening NN cord-028721-x6f26ahr 1454 20 of of IN cord-028721-x6f26ahr 1454 21 the the DT cord-028721-x6f26ahr 1454 22 fourth fourth JJ cord-028721-x6f26ahr 1454 23 metacarpal metacarpal NN cord-028721-x6f26ahr 1454 24 and and CC cord-028721-x6f26ahr 1454 25 Madelund Madelund NNP cord-028721-x6f26ahr 1454 26 's 's POS cord-028721-x6f26ahr 1454 27 deformity deformity NN cord-028721-x6f26ahr 1454 28 characteristic characteristic NN cord-028721-x6f26ahr 1454 29 of of IN cord-028721-x6f26ahr 1454 30 Leri Leri NNP cord-028721-x6f26ahr 1454 31 - - HYPH cord-028721-x6f26ahr 1454 32 Weill Weill NNP cord-028721-x6f26ahr 1454 33 dyschondrosteosis dyschondrosteosis NN cord-028721-x6f26ahr 1454 34 ; ; : cord-028721-x6f26ahr 1454 35 soft soft JJ cord-028721-x6f26ahr 1454 36 tissue tissue NN cord-028721-x6f26ahr 1454 37 anomalies anomaly NNS cord-028721-x6f26ahr 1454 38 such such JJ cord-028721-x6f26ahr 1454 39 as as IN cord-028721-x6f26ahr 1454 40 webbed webbed JJ cord-028721-x6f26ahr 1454 41 neck neck NN cord-028721-x6f26ahr 1454 42 , , , cord-028721-x6f26ahr 1454 43 low low JJ cord-028721-x6f26ahr 1454 44 posterior posterior JJ cord-028721-x6f26ahr 1454 45 hair hair NN cord-028721-x6f26ahr 1454 46 line line NN cord-028721-x6f26ahr 1454 47 , , , cord-028721-x6f26ahr 1454 48 and and CC cord-028721-x6f26ahr 1454 49 puffy puffy JJ cord-028721-x6f26ahr 1454 50 hands hand NNS cord-028721-x6f26ahr 1454 51 and and CC cord-028721-x6f26ahr 1454 52 feet foot NNS cord-028721-x6f26ahr 1454 53 ; ; : cord-028721-x6f26ahr 1454 54 visceral visceral JJ cord-028721-x6f26ahr 1454 55 anomalies anomaly NNS cord-028721-x6f26ahr 1454 56 such such JJ cord-028721-x6f26ahr 1454 57 as as IN cord-028721-x6f26ahr 1454 58 aortic aortic JJ cord-028721-x6f26ahr 1454 59 coarctation coarctation NN cord-028721-x6f26ahr 1454 60 , , , cord-028721-x6f26ahr 1454 61 horseshoe horseshoe NN cord-028721-x6f26ahr 1454 62 kidney kidney NN cord-028721-x6f26ahr 1454 63 , , , cord-028721-x6f26ahr 1454 64 polycystic polycystic JJ cord-028721-x6f26ahr 1454 65 kidney kidney NN cord-028721-x6f26ahr 1454 66 , , , cord-028721-x6f26ahr 1454 67 urethral urethral JJ cord-028721-x6f26ahr 1454 68 stenosis stenosis NN cord-028721-x6f26ahr 1454 69 and and CC cord-028721-x6f26ahr 1454 70 vesicourethral vesicourethral NNP cord-028721-x6f26ahr 1454 71 refl refl NNP cord-028721-x6f26ahr 1454 72 ux ux NNP cord-028721-x6f26ahr 1454 73 ; ; : cord-028721-x6f26ahr 1454 74 and and CC cord-028721-x6f26ahr 1454 75 miscellaneous miscellaneous JJ cord-028721-x6f26ahr 1454 76 anomalies anomaly NNS cord-028721-x6f26ahr 1454 77 such such JJ cord-028721-x6f26ahr 1454 78 as as IN cord-028721-x6f26ahr 1454 79 nevus nevus NN cord-028721-x6f26ahr 1454 80 pigmentosus pigmentosus NNP cord-028721-x6f26ahr 1454 81 . . . cord-028721-x6f26ahr 1455 1 663 663 CD cord-028721-x6f26ahr 1456 1 During during IN cord-028721-x6f26ahr 1456 2 embryonic embryonic JJ cord-028721-x6f26ahr 1456 3 life life NN cord-028721-x6f26ahr 1456 4 , , , cord-028721-x6f26ahr 1456 5 these these DT cord-028721-x6f26ahr 1456 6 gonads gonad NNS cord-028721-x6f26ahr 1456 7 show show VBP cord-028721-x6f26ahr 1456 8 normal normal JJ cord-028721-x6f26ahr 1456 9 germ germ NN cord-028721-x6f26ahr 1456 10 cell cell NN cord-028721-x6f26ahr 1456 11 numbers number NNS cord-028721-x6f26ahr 1456 12 up up IN cord-028721-x6f26ahr 1456 13 to to IN cord-028721-x6f26ahr 1456 14 the the DT cord-028721-x6f26ahr 1456 15 third third JJ cord-028721-x6f26ahr 1456 16 month month NN cord-028721-x6f26ahr 1456 17 , , , cord-028721-x6f26ahr 1456 18 when when WRB cord-028721-x6f26ahr 1456 19 germ germ NN cord-028721-x6f26ahr 1456 20 cell cell NN cord-028721-x6f26ahr 1456 21 proliferation proliferation NN cord-028721-x6f26ahr 1456 22 ceases cease VBZ cord-028721-x6f26ahr 1456 23 . . . cord-028721-x6f26ahr 1457 1 665 665 CD cord-028721-x6f26ahr 1457 2 , , , cord-028721-x6f26ahr 1457 3 666 666 CD cord-028721-x6f26ahr 1457 4 Ovogenesis Ovogenesis NNP cord-028721-x6f26ahr 1457 5 stops stop VBZ cord-028721-x6f26ahr 1457 6 in in IN cord-028721-x6f26ahr 1457 7 meiosis meiosis NN cord-028721-x6f26ahr 1458 1 I -PRON- PRP cord-028721-x6f26ahr 1458 2 , , , cord-028721-x6f26ahr 1458 3 usually usually RB cord-028721-x6f26ahr 1458 4 before before IN cord-028721-x6f26ahr 1458 5 the the DT cord-028721-x6f26ahr 1458 6 pachytene pachytene JJ cord-028721-x6f26ahr 1458 7 stage stage NN cord-028721-x6f26ahr 1458 8 . . . cord-028721-x6f26ahr 1459 1 The the DT cord-028721-x6f26ahr 1459 2 cause cause NN cord-028721-x6f26ahr 1459 3 seems seem VBZ cord-028721-x6f26ahr 1459 4 to to TO cord-028721-x6f26ahr 1459 5 be be VB cord-028721-x6f26ahr 1459 6 generalized generalize VBN cord-028721-x6f26ahr 1459 7 meiotic meiotic JJ cord-028721-x6f26ahr 1459 8 pairing pairing NN cord-028721-x6f26ahr 1459 9 errors error NNS cord-028721-x6f26ahr 1459 10 with with IN cord-028721-x6f26ahr 1459 11 the the DT cord-028721-x6f26ahr 1459 12 start start NN cord-028721-x6f26ahr 1459 13 of of IN cord-028721-x6f26ahr 1459 14 an an DT cord-028721-x6f26ahr 1459 15 apoptotic apoptotic JJ cord-028721-x6f26ahr 1459 16 mechanism mechanism NN cord-028721-x6f26ahr 1459 17 to to TO cord-028721-x6f26ahr 1459 18 avoid avoid VB cord-028721-x6f26ahr 1459 19 the the DT cord-028721-x6f26ahr 1459 20 formation formation NN cord-028721-x6f26ahr 1459 21 of of IN cord-028721-x6f26ahr 1459 22 abnormal abnormal JJ cord-028721-x6f26ahr 1459 23 gametes gamete NNS cord-028721-x6f26ahr 1459 24 . . . cord-028721-x6f26ahr 1460 1 667 667 CD cord-028721-x6f26ahr 1460 2 Massive massive JJ cord-028721-x6f26ahr 1460 3 apoptosis apoptosis NN cord-028721-x6f26ahr 1460 4 of of IN cord-028721-x6f26ahr 1460 5 ovocytes ovocyte NNS cord-028721-x6f26ahr 1460 6 occurs occur VBZ cord-028721-x6f26ahr 1460 7 between between IN cord-028721-x6f26ahr 1460 8 the the DT cord-028721-x6f26ahr 1460 9 15th 15th NN cord-028721-x6f26ahr 1460 10 and and CC cord-028721-x6f26ahr 1460 11 the the DT cord-028721-x6f26ahr 1460 12 20th 20th JJ cord-028721-x6f26ahr 1460 13 weeks week NNS cord-028721-x6f26ahr 1460 14 . . . cord-028721-x6f26ahr 1461 1 668 668 CD cord-028721-x6f26ahr 1461 2 Surviving survive VBG cord-028721-x6f26ahr 1461 3 germ germ NN cord-028721-x6f26ahr 1461 4 cells cell NNS cord-028721-x6f26ahr 1461 5 disappear disappear VBP cord-028721-x6f26ahr 1461 6 throughout throughout IN cord-028721-x6f26ahr 1461 7 fetal fetal JJ cord-028721-x6f26ahr 1461 8 life life NN cord-028721-x6f26ahr 1461 9 , , , cord-028721-x6f26ahr 1461 10 and and CC cord-028721-x6f26ahr 1461 11 their -PRON- PRP$ cord-028721-x6f26ahr 1461 12 numbers number NNS cord-028721-x6f26ahr 1461 13 at at IN cord-028721-x6f26ahr 1461 14 birth birth NN cord-028721-x6f26ahr 1461 15 are be VBP cord-028721-x6f26ahr 1461 16 usually usually RB cord-028721-x6f26ahr 1461 17 low low JJ cord-028721-x6f26ahr 1462 1 ( ( -LRB- cord-028721-x6f26ahr 1462 2 Fig Fig NNP cord-028721-x6f26ahr 1462 3 . . . cord-028721-x6f26ahr 1462 4 _SP cord-028721-x6f26ahr 1462 5 12 12 CD cord-028721-x6f26ahr 1462 6 - - SYM cord-028721-x6f26ahr 1462 7 66 66 CD cord-028721-x6f26ahr 1462 8 ) ) -RRB- cord-028721-x6f26ahr 1462 9 . . . cord-028721-x6f26ahr 1463 1 669 669 CD cord-028721-x6f26ahr 1463 2 Patients patient NNS cord-028721-x6f26ahr 1463 3 with with IN cord-028721-x6f26ahr 1463 4 mosaicism mosaicism NN cord-028721-x6f26ahr 1463 5 have have VBP cord-028721-x6f26ahr 1463 6 fewer few JJR cord-028721-x6f26ahr 1463 7 anomalies anomaly NNS cord-028721-x6f26ahr 1463 8 than than IN cord-028721-x6f26ahr 1463 9 pure pure JJ cord-028721-x6f26ahr 1463 10 45X0 45x0 CD cord-028721-x6f26ahr 1463 11 individuals individual NNS cord-028721-x6f26ahr 1463 12 ; ; : cord-028721-x6f26ahr 1463 13 12 12 CD cord-028721-x6f26ahr 1463 14 % % NN cord-028721-x6f26ahr 1463 15 have have VBP cord-028721-x6f26ahr 1463 16 menstruation menstruation NN cord-028721-x6f26ahr 1463 17 ( ( -LRB- cord-028721-x6f26ahr 1463 18 compared compare VBN cord-028721-x6f26ahr 1463 19 to to IN cord-028721-x6f26ahr 1463 20 3 3 CD cord-028721-x6f26ahr 1463 21 % % NN cord-028721-x6f26ahr 1463 22 of of IN cord-028721-x6f26ahr 1463 23 pure pure JJ cord-028721-x6f26ahr 1463 24 45X0 45x0 CD cord-028721-x6f26ahr 1463 25 patients patient NNS cord-028721-x6f26ahr 1463 26 ) ) -RRB- cord-028721-x6f26ahr 1463 27 , , , cord-028721-x6f26ahr 1463 28 and and CC cord-028721-x6f26ahr 1463 29 18 18 CD cord-028721-x6f26ahr 1463 30 % % NN cord-028721-x6f26ahr 1463 31 have have VBP cord-028721-x6f26ahr 1463 32 breast breast NN cord-028721-x6f26ahr 1463 33 development development NN cord-028721-x6f26ahr 1463 34 ( ( -LRB- cord-028721-x6f26ahr 1463 35 compared compare VBN cord-028721-x6f26ahr 1463 36 to to IN cord-028721-x6f26ahr 1463 37 5 5 CD cord-028721-x6f26ahr 1463 38 % % NN cord-028721-x6f26ahr 1463 39 of of IN cord-028721-x6f26ahr 1463 40 pure pure JJ cord-028721-x6f26ahr 1463 41 45X0 45x0 CD cord-028721-x6f26ahr 1463 42 patients patient NNS cord-028721-x6f26ahr 1463 43 ) ) -RRB- cord-028721-x6f26ahr 1463 44 . . . cord-028721-x6f26ahr 1464 1 In in IN cord-028721-x6f26ahr 1464 2 10 10 CD cord-028721-x6f26ahr 1464 3 - - SYM cord-028721-x6f26ahr 1464 4 20 20 CD cord-028721-x6f26ahr 1464 5 % % NN cord-028721-x6f26ahr 1464 6 of of IN cord-028721-x6f26ahr 1464 7 45X0 45x0 CD cord-028721-x6f26ahr 1464 8 patients patient NNS cord-028721-x6f26ahr 1464 9 the the DT cord-028721-x6f26ahr 1464 10 SRY SRY NNP cord-028721-x6f26ahr 1464 11 gene gene NN cord-028721-x6f26ahr 1464 12 is be VBZ cord-028721-x6f26ahr 1464 13 demonstrable demonstrable JJ cord-028721-x6f26ahr 1464 14 by by IN cord-028721-x6f26ahr 1464 15 in in IN cord-028721-x6f26ahr 1464 16 - - HYPH cord-028721-x6f26ahr 1464 17 situ situ NN cord-028721-x6f26ahr 1464 18 hybridization hybridization NN cord-028721-x6f26ahr 1464 19 . . . cord-028721-x6f26ahr 1465 1 It -PRON- PRP cord-028721-x6f26ahr 1465 2 has have VBZ cord-028721-x6f26ahr 1465 3 been be VBN cord-028721-x6f26ahr 1465 4 proposed propose VBN cord-028721-x6f26ahr 1465 5 that that IN cord-028721-x6f26ahr 1465 6 patients patient NNS cord-028721-x6f26ahr 1465 7 with with IN cord-028721-x6f26ahr 1465 8 SRY SRY NNP cord-028721-x6f26ahr 1465 9 expression expression NN cord-028721-x6f26ahr 1465 10 should should MD cord-028721-x6f26ahr 1465 11 undergo undergo VB cord-028721-x6f26ahr 1465 12 gonadectomy gonadectomy NN cord-028721-x6f26ahr 1465 13 , , , cord-028721-x6f26ahr 1465 14 because because IN cord-028721-x6f26ahr 1465 15 this this DT cord-028721-x6f26ahr 1465 16 gene gene NN cord-028721-x6f26ahr 1465 17 is be VBZ cord-028721-x6f26ahr 1465 18 also also RB cord-028721-x6f26ahr 1465 19 a a DT cord-028721-x6f26ahr 1465 20 marker marker NN cord-028721-x6f26ahr 1465 21 of of IN cord-028721-x6f26ahr 1465 22 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1465 23 . . . cord-028721-x6f26ahr 1466 1 670 670 CD cord-028721-x6f26ahr 1467 1 These these DT cord-028721-x6f26ahr 1467 2 patients patient NNS cord-028721-x6f26ahr 1467 3 may may MD cord-028721-x6f26ahr 1467 4 develop develop VB cord-028721-x6f26ahr 1467 5 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1467 6 , , , cord-028721-x6f26ahr 1467 7 dysgerminoma dysgerminoma NN cord-028721-x6f26ahr 1467 8 , , , cord-028721-x6f26ahr 1467 9 and and CC cord-028721-x6f26ahr 1467 10 mixed mixed JJ cord-028721-x6f26ahr 1467 11 germ germ NN cord-028721-x6f26ahr 1467 12 cell cell NN cord-028721-x6f26ahr 1467 13 tumor tumor NN cord-028721-x6f26ahr 1467 14 . . . cord-028721-x6f26ahr 1468 1 670 670 CD cord-028721-x6f26ahr 1468 2 , , , cord-028721-x6f26ahr 1468 3 671 671 CD cord-028721-x6f26ahr 1468 4 _SP cord-028721-x6f26ahr 1468 5 Mixed mixed JJ cord-028721-x6f26ahr 1468 6 gonadal gonadal JJ cord-028721-x6f26ahr 1468 7 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1468 8 is be VBZ cord-028721-x6f26ahr 1468 9 characterized characterize VBN cord-028721-x6f26ahr 1468 10 by by IN cord-028721-x6f26ahr 1468 11 the the DT cord-028721-x6f26ahr 1468 12 presence presence NN cord-028721-x6f26ahr 1468 13 of of IN cord-028721-x6f26ahr 1468 14 a a DT cord-028721-x6f26ahr 1468 15 streak streak NN cord-028721-x6f26ahr 1468 16 gonad gonad NN cord-028721-x6f26ahr 1468 17 and and CC cord-028721-x6f26ahr 1468 18 a a DT cord-028721-x6f26ahr 1468 19 contralateral contralateral JJ cord-028721-x6f26ahr 1468 20 testis testis NN cord-028721-x6f26ahr 1468 21 ( ( -LRB- cord-028721-x6f26ahr 1468 22 often often RB cord-028721-x6f26ahr 1468 23 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1468 24 ) ) -RRB- cord-028721-x6f26ahr 1468 25 or or CC cord-028721-x6f26ahr 1468 26 streak streak NN cord-028721-x6f26ahr 1468 27 testis testis NN cord-028721-x6f26ahr 1468 28 ( ( -LRB- cord-028721-x6f26ahr 1468 29 see see VB cord-028721-x6f26ahr 1468 30 discussion discussion NN cord-028721-x6f26ahr 1468 31 on on IN cord-028721-x6f26ahr 1468 32 male male JJ cord-028721-x6f26ahr 1468 33 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1468 34 with with IN cord-028721-x6f26ahr 1468 35 müllerian müllerian JJ cord-028721-x6f26ahr 1468 36 remnants remnant NNS cord-028721-x6f26ahr 1468 37 , , , cord-028721-x6f26ahr 1468 38 below below RB cord-028721-x6f26ahr 1468 39 ) ) -RRB- cord-028721-x6f26ahr 1468 40 . . . cord-028721-x6f26ahr 1469 1 True true JJ cord-028721-x6f26ahr 1469 2 hermaphroditism hermaphroditism NN cord-028721-x6f26ahr 1469 3 is be VBZ cord-028721-x6f26ahr 1469 4 a a DT cord-028721-x6f26ahr 1469 5 disorder disorder NN cord-028721-x6f26ahr 1469 6 of of IN cord-028721-x6f26ahr 1469 7 gonadal gonadal JJ cord-028721-x6f26ahr 1469 8 differentiation differentiation NN cord-028721-x6f26ahr 1469 9 characterized characterize VBN cord-028721-x6f26ahr 1469 10 by by IN cord-028721-x6f26ahr 1469 11 the the DT cord-028721-x6f26ahr 1469 12 presence presence NN cord-028721-x6f26ahr 1469 13 in in IN cord-028721-x6f26ahr 1469 14 the the DT cord-028721-x6f26ahr 1469 15 same same JJ cord-028721-x6f26ahr 1469 16 individual individual NN cord-028721-x6f26ahr 1469 17 of of IN cord-028721-x6f26ahr 1469 18 both both DT cord-028721-x6f26ahr 1469 19 testicular testicular JJ cord-028721-x6f26ahr 1469 20 and and CC cord-028721-x6f26ahr 1469 21 ovarian ovarian JJ cord-028721-x6f26ahr 1469 22 tissue tissue NN cord-028721-x6f26ahr 1469 23 . . . cord-028721-x6f26ahr 1470 1 This this DT cord-028721-x6f26ahr 1470 2 condition condition NN cord-028721-x6f26ahr 1470 3 is be VBZ cord-028721-x6f26ahr 1470 4 rare rare JJ cord-028721-x6f26ahr 1470 5 and and CC cord-028721-x6f26ahr 1470 6 usually usually RB cord-028721-x6f26ahr 1470 7 diffi diffi JJ cord-028721-x6f26ahr 1470 8 cult cult NN cord-028721-x6f26ahr 1470 9 to to TO cord-028721-x6f26ahr 1470 10 diagnose diagnose VB cord-028721-x6f26ahr 1470 11 , , , cord-028721-x6f26ahr 1470 12 so so RB cord-028721-x6f26ahr 1470 13 only only RB cord-028721-x6f26ahr 1470 14 25 25 CD cord-028721-x6f26ahr 1470 15 % % NN cord-028721-x6f26ahr 1470 16 of of IN cord-028721-x6f26ahr 1470 17 male male JJ cord-028721-x6f26ahr 1470 18 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1470 19 are be VBP cord-028721-x6f26ahr 1470 20 diagnosed diagnose VBN cord-028721-x6f26ahr 1470 21 before before IN cord-028721-x6f26ahr 1470 22 age age NN cord-028721-x6f26ahr 1470 23 20 20 CD cord-028721-x6f26ahr 1470 24 . . . cord-028721-x6f26ahr 1471 1 672 672 CD cord-028721-x6f26ahr 1471 2 Failure failure NN cord-028721-x6f26ahr 1471 3 to to TO cord-028721-x6f26ahr 1471 4 recognize recognize VB cord-028721-x6f26ahr 1471 5 this this DT cord-028721-x6f26ahr 1471 6 disorder disorder NN cord-028721-x6f26ahr 1471 7 may may MD cord-028721-x6f26ahr 1471 8 lead lead VB cord-028721-x6f26ahr 1471 9 to to IN cord-028721-x6f26ahr 1471 10 surgical surgical JJ cord-028721-x6f26ahr 1471 11 intervention intervention NN cord-028721-x6f26ahr 1471 12 for for IN cord-028721-x6f26ahr 1471 13 hernia hernia NN cord-028721-x6f26ahr 1471 14 repair repair NNP cord-028721-x6f26ahr 1471 15 or or CC cord-028721-x6f26ahr 1471 16 orchidopexy orchidopexy NN cord-028721-x6f26ahr 1471 17 . . . cord-028721-x6f26ahr 1472 1 Most Most JJS cord-028721-x6f26ahr 1472 2 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1472 3 raised raise VBN cord-028721-x6f26ahr 1472 4 as as IN cord-028721-x6f26ahr 1472 5 males male NNS cord-028721-x6f26ahr 1472 6 display display VBP cord-028721-x6f26ahr 1472 7 symptoms symptom NNS cord-028721-x6f26ahr 1472 8 for for IN cord-028721-x6f26ahr 1472 9 the the DT cord-028721-x6f26ahr 1472 10 fi fi NNP cord-028721-x6f26ahr 1472 11 rst rst NN cord-028721-x6f26ahr 1472 12 time time NN cord-028721-x6f26ahr 1472 13 at at IN cord-028721-x6f26ahr 1472 14 puberty puberty NN cord-028721-x6f26ahr 1472 15 because because IN cord-028721-x6f26ahr 1472 16 of of IN cord-028721-x6f26ahr 1472 17 breast breast NN cord-028721-x6f26ahr 1472 18 development development NN cord-028721-x6f26ahr 1472 19 673 673 CD cord-028721-x6f26ahr 1472 20 ( ( -LRB- cord-028721-x6f26ahr 1472 21 95 95 CD cord-028721-x6f26ahr 1472 22 % % NN cord-028721-x6f26ahr 1472 23 of of IN cord-028721-x6f26ahr 1472 24 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1472 25 have have VBP cord-028721-x6f26ahr 1472 26 some some DT cord-028721-x6f26ahr 1472 27 degree degree NN cord-028721-x6f26ahr 1472 28 of of IN cord-028721-x6f26ahr 1472 29 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1472 30 ) ) -RRB- cord-028721-x6f26ahr 1472 31 , , , cord-028721-x6f26ahr 1472 32 periodic periodic JJ cord-028721-x6f26ahr 1472 33 hematuria hematuria NN cord-028721-x6f26ahr 1472 34 674 674 CD cord-028721-x6f26ahr 1473 1 ( ( -LRB- cord-028721-x6f26ahr 1473 2 if if IN cord-028721-x6f26ahr 1473 3 they -PRON- PRP cord-028721-x6f26ahr 1473 4 have have VBP cord-028721-x6f26ahr 1473 5 a a DT cord-028721-x6f26ahr 1473 6 uterus uterus NN cord-028721-x6f26ahr 1473 7 ending end VBG cord-028721-x6f26ahr 1473 8 in in IN cord-028721-x6f26ahr 1473 9 the the DT cord-028721-x6f26ahr 1473 10 urinary urinary JJ cord-028721-x6f26ahr 1473 11 tract tract NN cord-028721-x6f26ahr 1473 12 ) ) -RRB- cord-028721-x6f26ahr 1473 13 , , , cord-028721-x6f26ahr 1473 14 or or CC cord-028721-x6f26ahr 1473 15 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1473 16 . . . cord-028721-x6f26ahr 1474 1 675 675 CD cord-028721-x6f26ahr 1474 2 Hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1474 3 raised raise VBN cord-028721-x6f26ahr 1474 4 as as IN cord-028721-x6f26ahr 1474 5 females female NNS cord-028721-x6f26ahr 1474 6 initially initially RB cord-028721-x6f26ahr 1474 7 present present JJ cord-028721-x6f26ahr 1474 8 with with IN cord-028721-x6f26ahr 1474 9 irregular irregular JJ cord-028721-x6f26ahr 1474 10 menstruation menstruation NN cord-028721-x6f26ahr 1474 11 or or CC cord-028721-x6f26ahr 1474 12 clitoromegaly clitoromegaly NN cord-028721-x6f26ahr 1474 13 . . . cord-028721-x6f26ahr 1475 1 True true JJ cord-028721-x6f26ahr 1475 2 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1475 3 should should MD cord-028721-x6f26ahr 1475 4 be be VB cord-028721-x6f26ahr 1475 5 suspected suspect VBN cord-028721-x6f26ahr 1475 6 in in IN cord-028721-x6f26ahr 1475 7 all all DT cord-028721-x6f26ahr 1475 8 children child NNS cord-028721-x6f26ahr 1475 9 with with IN cord-028721-x6f26ahr 1475 10 ambiguous ambiguous JJ cord-028721-x6f26ahr 1475 11 sex sex NN cord-028721-x6f26ahr 1475 12 characteristics characteristic NNS cord-028721-x6f26ahr 1475 13 ( ( -LRB- cord-028721-x6f26ahr 1475 14 Fig Fig NNP cord-028721-x6f26ahr 1475 15 . . . cord-028721-x6f26ahr 1475 16 12 12 CD cord-028721-x6f26ahr 1475 17 - - SYM cord-028721-x6f26ahr 1475 18 67 67 CD cord-028721-x6f26ahr 1475 19 ) ) -RRB- cord-028721-x6f26ahr 1475 20 . . . cord-028721-x6f26ahr 1476 1 The the DT cord-028721-x6f26ahr 1476 2 gonads gonad NNS cord-028721-x6f26ahr 1476 3 of of IN cord-028721-x6f26ahr 1476 4 these these DT cord-028721-x6f26ahr 1476 5 patients patient NNS cord-028721-x6f26ahr 1476 6 are be VBP cord-028721-x6f26ahr 1476 7 ovotestes ovotestis NNS cord-028721-x6f26ahr 1476 8 , , , cord-028721-x6f26ahr 1476 9 ovaries ovary NNS cord-028721-x6f26ahr 1476 10 , , , cord-028721-x6f26ahr 1476 11 or or CC cord-028721-x6f26ahr 1476 12 testes testis NNS cord-028721-x6f26ahr 1476 13 , , , cord-028721-x6f26ahr 1476 14 with with IN cord-028721-x6f26ahr 1476 15 all all DT cord-028721-x6f26ahr 1476 16 possible possible JJ cord-028721-x6f26ahr 1476 17 combinations combination NNS cord-028721-x6f26ahr 1476 18 . . . cord-028721-x6f26ahr 1477 1 676 676 CD cord-028721-x6f26ahr 1478 1 True true JJ cord-028721-x6f26ahr 1478 2 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1478 3 can can MD cord-028721-x6f26ahr 1478 4 be be VB cord-028721-x6f26ahr 1478 5 ( ( -LRB- cord-028721-x6f26ahr 1478 6 1 1 LS cord-028721-x6f26ahr 1478 7 ) ) -RRB- cord-028721-x6f26ahr 1478 8 unilateral unilateral JJ cord-028721-x6f26ahr 1478 9 , , , cord-028721-x6f26ahr 1478 10 if if IN cord-028721-x6f26ahr 1478 11 there there EX cord-028721-x6f26ahr 1478 12 are be VBP cord-028721-x6f26ahr 1478 13 both both DT cord-028721-x6f26ahr 1478 14 testicular testicular JJ cord-028721-x6f26ahr 1478 15 and and CC cord-028721-x6f26ahr 1478 16 ovarian ovarian JJ cord-028721-x6f26ahr 1478 17 tissues tissue NNS cord-028721-x6f26ahr 1478 18 ( ( -LRB- cord-028721-x6f26ahr 1478 19 forming form VBG cord-028721-x6f26ahr 1478 20 one one CD cord-028721-x6f26ahr 1478 21 ovotestes ovotestis NNS cord-028721-x6f26ahr 1478 22 or or CC cord-028721-x6f26ahr 1478 23 two two CD cord-028721-x6f26ahr 1478 24 separated separated JJ cord-028721-x6f26ahr 1478 25 gonads gonad NNS cord-028721-x6f26ahr 1478 26 ) ) -RRB- cord-028721-x6f26ahr 1478 27 on on IN cord-028721-x6f26ahr 1478 28 one one CD cord-028721-x6f26ahr 1478 29 side side NN cord-028721-x6f26ahr 1478 30 , , , cord-028721-x6f26ahr 1478 31 and and CC cord-028721-x6f26ahr 1478 32 a a DT cord-028721-x6f26ahr 1478 33 testis testis NN cord-028721-x6f26ahr 1478 34 or or CC cord-028721-x6f26ahr 1478 35 an an DT cord-028721-x6f26ahr 1478 36 ovary ovary NN cord-028721-x6f26ahr 1478 37 in in IN cord-028721-x6f26ahr 1478 38 the the DT cord-028721-x6f26ahr 1478 39 other other JJ cord-028721-x6f26ahr 1478 40 side side NN cord-028721-x6f26ahr 1478 41 ; ; : cord-028721-x6f26ahr 1478 42 if if IN cord-028721-x6f26ahr 1478 43 there there EX cord-028721-x6f26ahr 1478 44 is be VBZ cord-028721-x6f26ahr 1478 45 no no DT cord-028721-x6f26ahr 1478 46 gonadal gonadal JJ cord-028721-x6f26ahr 1478 47 tissue tissue NN cord-028721-x6f26ahr 1478 48 in in IN cord-028721-x6f26ahr 1478 49 this this DT cord-028721-x6f26ahr 1478 50 latter latter JJ cord-028721-x6f26ahr 1478 51 side side NN cord-028721-x6f26ahr 1478 52 , , , cord-028721-x6f26ahr 1478 53 unilateral unilateral JJ cord-028721-x6f26ahr 1478 54 hermaphroditism hermaphroditism NN cord-028721-x6f26ahr 1478 55 is be VBZ cord-028721-x6f26ahr 1478 56 incomplete incomplete JJ cord-028721-x6f26ahr 1478 57 ; ; : cord-028721-x6f26ahr 1478 58 ( ( -LRB- cord-028721-x6f26ahr 1478 59 2 2 LS cord-028721-x6f26ahr 1478 60 ) ) -RRB- cord-028721-x6f26ahr 1478 61 bilateral bilateral JJ cord-028721-x6f26ahr 1478 62 , , , cord-028721-x6f26ahr 1478 63 if if IN cord-028721-x6f26ahr 1478 64 testicular testicular NN cord-028721-x6f26ahr 1478 65 and and CC cord-028721-x6f26ahr 1478 66 ovarian ovarian JJ cord-028721-x6f26ahr 1478 67 tissues tissue NNS cord-028721-x6f26ahr 1478 68 are be VBP cord-028721-x6f26ahr 1478 69 present present JJ cord-028721-x6f26ahr 1478 70 on on IN cord-028721-x6f26ahr 1478 71 both both DT cord-028721-x6f26ahr 1478 72 sides side NNS cord-028721-x6f26ahr 1478 73 of of IN cord-028721-x6f26ahr 1478 74 the the DT cord-028721-x6f26ahr 1478 75 body body NN cord-028721-x6f26ahr 1478 76 ; ; : cord-028721-x6f26ahr 1478 77 and and CC cord-028721-x6f26ahr 1478 78 ( ( -LRB- cord-028721-x6f26ahr 1478 79 3 3 LS cord-028721-x6f26ahr 1478 80 ) ) -RRB- cord-028721-x6f26ahr 1478 81 alternate alternate JJ cord-028721-x6f26ahr 1478 82 , , , cord-028721-x6f26ahr 1478 83 if if IN cord-028721-x6f26ahr 1478 84 there there EX cord-028721-x6f26ahr 1478 85 is be VBZ cord-028721-x6f26ahr 1478 86 a a DT cord-028721-x6f26ahr 1478 87 testis testis NN cord-028721-x6f26ahr 1478 88 on on IN cord-028721-x6f26ahr 1478 89 one one CD cord-028721-x6f26ahr 1478 90 side side NN cord-028721-x6f26ahr 1478 91 , , , cord-028721-x6f26ahr 1478 92 and and CC cord-028721-x6f26ahr 1478 93 an an DT cord-028721-x6f26ahr 1478 94 ovary ovary NN cord-028721-x6f26ahr 1478 95 on on IN cord-028721-x6f26ahr 1478 96 the the DT cord-028721-x6f26ahr 1478 97 other other JJ cord-028721-x6f26ahr 1478 98 side side NN cord-028721-x6f26ahr 1478 99 . . . cord-028721-x6f26ahr 1479 1 Ovotestis Ovotestis NNP cord-028721-x6f26ahr 1479 2 is be VBZ cord-028721-x6f26ahr 1479 3 the the DT cord-028721-x6f26ahr 1479 4 most most RBS cord-028721-x6f26ahr 1479 5 frequent frequent JJ cord-028721-x6f26ahr 1479 6 gonadal gonadal JJ cord-028721-x6f26ahr 1479 7 type type NN cord-028721-x6f26ahr 1479 8 in in IN cord-028721-x6f26ahr 1479 9 true true JJ cord-028721-x6f26ahr 1479 10 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1479 11 . . . cord-028721-x6f26ahr 1480 1 It -PRON- PRP cord-028721-x6f26ahr 1480 2 is be VBZ cord-028721-x6f26ahr 1480 3 more more RBR cord-028721-x6f26ahr 1480 4 frequent frequent JJ cord-028721-x6f26ahr 1480 5 on on IN cord-028721-x6f26ahr 1480 6 the the DT cord-028721-x6f26ahr 1480 7 right right JJ cord-028721-x6f26ahr 1480 8 side side NN cord-028721-x6f26ahr 1480 9 and and CC cord-028721-x6f26ahr 1480 10 is be VBZ cord-028721-x6f26ahr 1480 11 located locate VBN cord-028721-x6f26ahr 1480 12 in in IN cord-028721-x6f26ahr 1480 13 the the DT cord-028721-x6f26ahr 1480 14 abdomen abdoman NNS cord-028721-x6f26ahr 1480 15 ( ( -LRB- cord-028721-x6f26ahr 1480 16 50 50 CD cord-028721-x6f26ahr 1480 17 % % NN cord-028721-x6f26ahr 1480 18 of of IN cord-028721-x6f26ahr 1480 19 cases case NNS cord-028721-x6f26ahr 1480 20 ) ) -RRB- cord-028721-x6f26ahr 1480 21 , , , cord-028721-x6f26ahr 1480 22 labioscrotal labioscrotal NNP cord-028721-x6f26ahr 1480 23 folds fold VBZ cord-028721-x6f26ahr 1480 24 , , , cord-028721-x6f26ahr 1480 25 inguinal inguinal JJ cord-028721-x6f26ahr 1480 26 canal canal NN cord-028721-x6f26ahr 1480 27 , , , cord-028721-x6f26ahr 1480 28 or or CC cord-028721-x6f26ahr 1480 29 the the DT cord-028721-x6f26ahr 1480 30 external external JJ cord-028721-x6f26ahr 1480 31 inguinal inguinal JJ cord-028721-x6f26ahr 1480 32 ring ring NN cord-028721-x6f26ahr 1480 33 . . . cord-028721-x6f26ahr 1481 1 The the DT cord-028721-x6f26ahr 1481 2 ovotestis ovotestis NN cord-028721-x6f26ahr 1481 3 has have VBZ cord-028721-x6f26ahr 1481 4 a a DT cord-028721-x6f26ahr 1481 5 bilobated bilobate VBN cord-028721-x6f26ahr 1481 6 or or CC cord-028721-x6f26ahr 1481 7 ovoid ovoid JJ cord-028721-x6f26ahr 1481 8 shape shape NN cord-028721-x6f26ahr 1481 9 ( ( -LRB- cord-028721-x6f26ahr 1481 10 Fig Fig NNP cord-028721-x6f26ahr 1481 11 . . . cord-028721-x6f26ahr 1481 12 12 12 CD cord-028721-x6f26ahr 1481 13 - - SYM cord-028721-x6f26ahr 1481 14 68 68 CD cord-028721-x6f26ahr 1481 15 ) ) -RRB- cord-028721-x6f26ahr 1481 16 . . . cord-028721-x6f26ahr 1482 1 In in IN cord-028721-x6f26ahr 1482 2 the the DT cord-028721-x6f26ahr 1482 3 bilobated bilobated JJ cord-028721-x6f26ahr 1482 4 ovotestis ovotestis NN cord-028721-x6f26ahr 1482 5 the the DT cord-028721-x6f26ahr 1482 6 testis testis NN cord-028721-x6f26ahr 1482 7 and and CC cord-028721-x6f26ahr 1482 8 ovary ovary NN cord-028721-x6f26ahr 1482 9 are be VBP cord-028721-x6f26ahr 1482 10 connected connect VBN cord-028721-x6f26ahr 1482 11 by by IN cord-028721-x6f26ahr 1482 12 a a DT cord-028721-x6f26ahr 1482 13 pedicle pedicle NN cord-028721-x6f26ahr 1482 14 , , , cord-028721-x6f26ahr 1482 15 whereas whereas IN cord-028721-x6f26ahr 1482 16 in in IN cord-028721-x6f26ahr 1482 17 the the DT cord-028721-x6f26ahr 1482 18 ovoid ovoid JJ cord-028721-x6f26ahr 1482 19 ovotestis ovotestis NN cord-028721-x6f26ahr 1482 20 the the DT cord-028721-x6f26ahr 1482 21 ovarian ovarian JJ cord-028721-x6f26ahr 1482 22 tissue tissue NN cord-028721-x6f26ahr 1482 23 forms form VBZ cord-028721-x6f26ahr 1482 24 a a DT cord-028721-x6f26ahr 1482 25 crescent crescent NN cord-028721-x6f26ahr 1482 26 capping cap VBG cord-028721-x6f26ahr 1482 27 the the DT cord-028721-x6f26ahr 1482 28 testicular testicular JJ cord-028721-x6f26ahr 1482 29 parenchyma parenchyma NN cord-028721-x6f26ahr 1482 30 . . . cord-028721-x6f26ahr 1483 1 The the DT cord-028721-x6f26ahr 1483 2 proportion proportion NN cord-028721-x6f26ahr 1483 3 of of IN cord-028721-x6f26ahr 1483 4 ovary ovary NN cord-028721-x6f26ahr 1483 5 to to IN cord-028721-x6f26ahr 1483 6 testis testis NN cord-028721-x6f26ahr 1483 7 varies vary VBZ cord-028721-x6f26ahr 1483 8 widely widely RB cord-028721-x6f26ahr 1483 9 ( ( -LRB- cord-028721-x6f26ahr 1483 10 Fig Fig NNP cord-028721-x6f26ahr 1483 11 . . . cord-028721-x6f26ahr 1483 12 12 12 CD cord-028721-x6f26ahr 1483 13 - - SYM cord-028721-x6f26ahr 1483 14 69 69 CD cord-028721-x6f26ahr 1483 15 ) ) -RRB- cord-028721-x6f26ahr 1483 16 . . . cord-028721-x6f26ahr 1484 1 At at IN cord-028721-x6f26ahr 1484 2 adulthood adulthood NN cord-028721-x6f26ahr 1484 3 , , , cord-028721-x6f26ahr 1484 4 the the DT cord-028721-x6f26ahr 1484 5 ovarian ovarian JJ cord-028721-x6f26ahr 1484 6 follicles follicle NNS cord-028721-x6f26ahr 1484 7 mature mature VBP cord-028721-x6f26ahr 1484 8 and and CC cord-028721-x6f26ahr 1484 9 corpora corpora JJ cord-028721-x6f26ahr 1484 10 lutea lutea NN cord-028721-x6f26ahr 1484 11 or or CC cord-028721-x6f26ahr 1484 12 corpora corpora NN cord-028721-x6f26ahr 1484 13 albicantia albicantia NN cord-028721-x6f26ahr 1484 14 may may MD cord-028721-x6f26ahr 1484 15 be be VB cord-028721-x6f26ahr 1484 16 seen see VBN cord-028721-x6f26ahr 1484 17 . . . cord-028721-x6f26ahr 1485 1 The the DT cord-028721-x6f26ahr 1485 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1485 3 tubules tubule NNS cord-028721-x6f26ahr 1485 4 rarely rarely RB cord-028721-x6f26ahr 1485 5 develop develop VBP cord-028721-x6f26ahr 1485 6 complete complete JJ cord-028721-x6f26ahr 1485 7 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1485 8 . . . cord-028721-x6f26ahr 1486 1 The the DT cord-028721-x6f26ahr 1486 2 interstitium interstitium NN cord-028721-x6f26ahr 1486 3 usually usually RB cord-028721-x6f26ahr 1486 4 contains contain VBZ cord-028721-x6f26ahr 1486 5 Leydig leydig NN cord-028721-x6f26ahr 1486 6 cells cell NNS cord-028721-x6f26ahr 1486 7 . . . cord-028721-x6f26ahr 1487 1 Ovotestis Ovotestis NNP cord-028721-x6f26ahr 1487 2 is be VBZ cord-028721-x6f26ahr 1487 3 associated associate VBN cord-028721-x6f26ahr 1487 4 with with IN cord-028721-x6f26ahr 1487 5 a a DT cord-028721-x6f26ahr 1487 6 fallopian fallopian JJ cord-028721-x6f26ahr 1487 7 tube tube NN cord-028721-x6f26ahr 1487 8 in in IN cord-028721-x6f26ahr 1487 9 65 65 CD cord-028721-x6f26ahr 1487 10 % % NN cord-028721-x6f26ahr 1487 11 of of IN cord-028721-x6f26ahr 1487 12 cases case NNS cord-028721-x6f26ahr 1487 13 , , , cord-028721-x6f26ahr 1487 14 and and CC cord-028721-x6f26ahr 1487 15 with with IN cord-028721-x6f26ahr 1487 16 a a DT cord-028721-x6f26ahr 1487 17 vas vas FW cord-028721-x6f26ahr 1487 18 deferens deferen NNS cord-028721-x6f26ahr 1487 19 in in IN cord-028721-x6f26ahr 1487 20 the the DT cord-028721-x6f26ahr 1487 21 remainder remainder NN cord-028721-x6f26ahr 1487 22 . . . cord-028721-x6f26ahr 1488 1 If if IN cord-028721-x6f26ahr 1488 2 the the DT cord-028721-x6f26ahr 1488 3 patient patient NN cord-028721-x6f26ahr 1488 4 has have VBZ cord-028721-x6f26ahr 1488 5 ovotestis ovotestis NNP cord-028721-x6f26ahr 1488 6 / / SYM cord-028721-x6f26ahr 1488 7 ovary ovary NN cord-028721-x6f26ahr 1488 8 , , , cord-028721-x6f26ahr 1488 9 a a DT cord-028721-x6f26ahr 1488 10 completely completely RB cord-028721-x6f26ahr 1488 11 developed develop VBN cord-028721-x6f26ahr 1488 12 uterus uterus NN cord-028721-x6f26ahr 1488 13 is be VBZ cord-028721-x6f26ahr 1488 14 present present JJ cord-028721-x6f26ahr 1488 15 . . . cord-028721-x6f26ahr 1489 1 If if IN cord-028721-x6f26ahr 1489 2 the the DT cord-028721-x6f26ahr 1489 3 patient patient NN cord-028721-x6f26ahr 1489 4 has have VBZ cord-028721-x6f26ahr 1489 5 bilateral bilateral JJ cord-028721-x6f26ahr 1489 6 ovotestis ovotestis NN cord-028721-x6f26ahr 1489 7 ( ( -LRB- cord-028721-x6f26ahr 1489 8 13 13 CD cord-028721-x6f26ahr 1489 9 % % NN cord-028721-x6f26ahr 1489 10 ) ) -RRB- cord-028721-x6f26ahr 1489 11 , , , cord-028721-x6f26ahr 1489 12 uterine uterine JJ cord-028721-x6f26ahr 1489 13 agenesis agenesis NN cord-028721-x6f26ahr 1489 14 is be VBZ cord-028721-x6f26ahr 1489 15 frequent frequent JJ cord-028721-x6f26ahr 1489 16 ( ( -LRB- cord-028721-x6f26ahr 1489 17 Fig Fig NNP cord-028721-x6f26ahr 1489 18 . . . cord-028721-x6f26ahr 1489 19 12 12 CD cord-028721-x6f26ahr 1489 20 - - SYM cord-028721-x6f26ahr 1489 21 70 70 CD cord-028721-x6f26ahr 1489 22 ) ) -RRB- cord-028721-x6f26ahr 1489 23 . . . cord-028721-x6f26ahr 1490 1 677 677 CD cord-028721-x6f26ahr 1491 1 The the DT cord-028721-x6f26ahr 1491 2 testis testis NN cord-028721-x6f26ahr 1491 3 of of IN cord-028721-x6f26ahr 1491 4 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1491 5 is be VBZ cord-028721-x6f26ahr 1491 6 most most RBS cord-028721-x6f26ahr 1491 7 often often RB cord-028721-x6f26ahr 1491 8 on on IN cord-028721-x6f26ahr 1491 9 the the DT cord-028721-x6f26ahr 1491 10 right right JJ cord-028721-x6f26ahr 1491 11 side side NN cord-028721-x6f26ahr 1491 12 ( ( -LRB- cord-028721-x6f26ahr 1491 13 60 60 CD cord-028721-x6f26ahr 1491 14 % % NN cord-028721-x6f26ahr 1491 15 ) ) -RRB- cord-028721-x6f26ahr 1491 16 and and CC cord-028721-x6f26ahr 1491 17 is be VBZ cord-028721-x6f26ahr 1491 18 located locate VBN cord-028721-x6f26ahr 1491 19 anywhere anywhere RB cord-028721-x6f26ahr 1491 20 from from IN cord-028721-x6f26ahr 1491 21 the the DT cord-028721-x6f26ahr 1491 22 abdomen abdomen NN cord-028721-x6f26ahr 1491 23 to to IN cord-028721-x6f26ahr 1491 24 the the DT cord-028721-x6f26ahr 1491 25 scrotum scrotum NN cord-028721-x6f26ahr 1491 26 . . . cord-028721-x6f26ahr 1492 1 These these DT cord-028721-x6f26ahr 1492 2 testes testis NNS cord-028721-x6f26ahr 1492 3 have have VBP cord-028721-x6f26ahr 1492 4 low low JJ cord-028721-x6f26ahr 1492 5 tubular tubular JJ cord-028721-x6f26ahr 1492 6 fertility fertility NN cord-028721-x6f26ahr 1492 7 indices index NNS cord-028721-x6f26ahr 1492 8 during during IN cord-028721-x6f26ahr 1492 9 childhood childhood NN cord-028721-x6f26ahr 1492 10 . . . cord-028721-x6f26ahr 1493 1 After after IN cord-028721-x6f26ahr 1493 2 puberty puberty NN cord-028721-x6f26ahr 1493 3 , , , cord-028721-x6f26ahr 1493 4 the the DT cord-028721-x6f26ahr 1493 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 1493 6 tubules tubule NNS cord-028721-x6f26ahr 1493 7 remain remain VBP cord-028721-x6f26ahr 1493 8 small small JJ cord-028721-x6f26ahr 1493 9 , , , cord-028721-x6f26ahr 1493 10 often often RB cord-028721-x6f26ahr 1493 11 containing contain VBG cord-028721-x6f26ahr 1493 12 only only RB cord-028721-x6f26ahr 1493 13 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1493 14 Sertoli Sertoli NNP cord-028721-x6f26ahr 1493 15 cells cell NNS cord-028721-x6f26ahr 1493 16 , , , cord-028721-x6f26ahr 1493 17 similar similar JJ cord-028721-x6f26ahr 1493 18 to to IN cord-028721-x6f26ahr 1493 19 the the DT cord-028721-x6f26ahr 1493 20 tubules tubule NNS cord-028721-x6f26ahr 1493 21 of of IN cord-028721-x6f26ahr 1493 22 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1493 23 testes testis NNS cord-028721-x6f26ahr 1493 24 . . . cord-028721-x6f26ahr 1494 1 Incomplete incomplete JJ cord-028721-x6f26ahr 1494 2 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1494 3 has have VBZ cord-028721-x6f26ahr 1494 4 been be VBN cord-028721-x6f26ahr 1494 5 reported report VBN cord-028721-x6f26ahr 1494 6 , , , cord-028721-x6f26ahr 1494 7 but but CC cord-028721-x6f26ahr 1494 8 complete complete JJ cord-028721-x6f26ahr 1494 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1494 10 is be VBZ cord-028721-x6f26ahr 1494 11 exceptional exceptional JJ cord-028721-x6f26ahr 1494 12 . . . cord-028721-x6f26ahr 1495 1 The the DT cord-028721-x6f26ahr 1495 2 ovary ovary NN cord-028721-x6f26ahr 1495 3 of of IN cord-028721-x6f26ahr 1495 4 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1495 5 is be VBZ cord-028721-x6f26ahr 1495 6 most most RBS cord-028721-x6f26ahr 1495 7 frequently frequently RB cord-028721-x6f26ahr 1495 8 on on IN cord-028721-x6f26ahr 1495 9 the the DT cord-028721-x6f26ahr 1495 10 left left JJ cord-028721-x6f26ahr 1495 11 side side NN cord-028721-x6f26ahr 1495 12 ( ( -LRB- cord-028721-x6f26ahr 1495 13 63 63 CD cord-028721-x6f26ahr 1495 14 % % NN cord-028721-x6f26ahr 1495 15 ) ) -RRB- cord-028721-x6f26ahr 1495 16 and and CC cord-028721-x6f26ahr 1495 17 usually usually RB cord-028721-x6f26ahr 1495 18 is be VBZ cord-028721-x6f26ahr 1495 19 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1495 20 with with IN cord-028721-x6f26ahr 1495 21 few few JJ cord-028721-x6f26ahr 1495 22 primordial primordial JJ cord-028721-x6f26ahr 1495 23 follicles follicle NNS cord-028721-x6f26ahr 1495 24 . . . cord-028721-x6f26ahr 1496 1 However however RB cord-028721-x6f26ahr 1496 2 , , , cord-028721-x6f26ahr 1496 3 in in IN cord-028721-x6f26ahr 1496 4 occasional occasional JJ cord-028721-x6f26ahr 1496 5 patients patient NNS cord-028721-x6f26ahr 1496 6 the the DT cord-028721-x6f26ahr 1496 7 ovary ovary NN cord-028721-x6f26ahr 1496 8 is be VBZ cord-028721-x6f26ahr 1496 9 histologically histologically RB cord-028721-x6f26ahr 1496 10 and and CC cord-028721-x6f26ahr 1496 11 functionally functionally RB cord-028721-x6f26ahr 1496 12 normal normal JJ cord-028721-x6f26ahr 1496 13 . . . cord-028721-x6f26ahr 1497 1 The the DT cord-028721-x6f26ahr 1497 2 most most RBS cord-028721-x6f26ahr 1497 3 frequent frequent JJ cord-028721-x6f26ahr 1497 4 karyotype karyotype NN cord-028721-x6f26ahr 1497 5 is be VBZ cord-028721-x6f26ahr 1497 6 46XX 46xx CD cord-028721-x6f26ahr 1497 7 ( ( -LRB- cord-028721-x6f26ahr 1497 8 60 60 CD cord-028721-x6f26ahr 1497 9 % % NN cord-028721-x6f26ahr 1497 10 ) ) -RRB- cord-028721-x6f26ahr 1497 11 , , , cord-028721-x6f26ahr 1497 12 followed follow VBN cord-028721-x6f26ahr 1497 13 by by IN cord-028721-x6f26ahr 1497 14 several several JJ cord-028721-x6f26ahr 1497 15 mosaicisms mosaicism NNS cord-028721-x6f26ahr 1497 16 ( ( -LRB- cord-028721-x6f26ahr 1497 17 33 33 CD cord-028721-x6f26ahr 1497 18 % % NN cord-028721-x6f26ahr 1497 19 ) ) -RRB- cord-028721-x6f26ahr 1497 20 which which WDT cord-028721-x6f26ahr 1497 21 , , , cord-028721-x6f26ahr 1497 22 in in IN cord-028721-x6f26ahr 1497 23 decreasing decrease VBG cord-028721-x6f26ahr 1497 24 order order NN cord-028721-x6f26ahr 1497 25 of of IN cord-028721-x6f26ahr 1497 26 frequency frequency NN cord-028721-x6f26ahr 1497 27 , , , cord-028721-x6f26ahr 1497 28 are be VBP cord-028721-x6f26ahr 1497 29 46XX/46XY 46xx/46xy CD cord-028721-x6f26ahr 1497 30 , , , cord-028721-x6f26ahr 1497 31 46XY/47XXY 46xy/47xxy CD cord-028721-x6f26ahr 1497 32 , , , cord-028721-x6f26ahr 1497 33 45X0/46XY 45x0/46xy CD cord-028721-x6f26ahr 1497 34 , , , cord-028721-x6f26ahr 1497 35 46XX/47XXY 46xx/47xxy CD cord-028721-x6f26ahr 1497 36 . . . cord-028721-x6f26ahr 1498 1 The the DT cord-028721-x6f26ahr 1498 2 46XY 46xy CD cord-028721-x6f26ahr 1498 3 karyotype karyotype NN cord-028721-x6f26ahr 1498 4 is be VBZ cord-028721-x6f26ahr 1498 5 the the DT cord-028721-x6f26ahr 1498 6 least least JJS cord-028721-x6f26ahr 1498 7 common common JJ cord-028721-x6f26ahr 1498 8 ( ( -LRB- cord-028721-x6f26ahr 1498 9 7 7 CD cord-028721-x6f26ahr 1498 10 % % NN cord-028721-x6f26ahr 1498 11 ) ) -RRB- cord-028721-x6f26ahr 1498 12 . . . cord-028721-x6f26ahr 1499 1 There there EX cord-028721-x6f26ahr 1499 2 is be VBZ cord-028721-x6f26ahr 1499 3 variation variation NN cord-028721-x6f26ahr 1499 4 in in IN cord-028721-x6f26ahr 1499 5 the the DT cord-028721-x6f26ahr 1499 6 incidence incidence NN cord-028721-x6f26ahr 1499 7 of of IN cord-028721-x6f26ahr 1499 8 some some DT cord-028721-x6f26ahr 1499 9 karyotypes karyotype NNS cord-028721-x6f26ahr 1499 10 around around IN cord-028721-x6f26ahr 1499 11 the the DT cord-028721-x6f26ahr 1499 12 world world NN cord-028721-x6f26ahr 1499 13 . . . cord-028721-x6f26ahr 1500 1 Mosaicism Mosaicism NNP cord-028721-x6f26ahr 1500 2 is be VBZ cord-028721-x6f26ahr 1500 3 found find VBN cord-028721-x6f26ahr 1500 4 in in IN cord-028721-x6f26ahr 1500 5 40.5 40.5 CD cord-028721-x6f26ahr 1500 6 % % NN cord-028721-x6f26ahr 1500 7 of of IN cord-028721-x6f26ahr 1500 8 European european JJ cord-028721-x6f26ahr 1500 9 cases case NNS cord-028721-x6f26ahr 1500 10 , , , cord-028721-x6f26ahr 1500 11 but but CC cord-028721-x6f26ahr 1500 12 in in IN cord-028721-x6f26ahr 1500 13 only only RB cord-028721-x6f26ahr 1500 14 21 21 CD cord-028721-x6f26ahr 1500 15 % % NN cord-028721-x6f26ahr 1500 16 of of IN cord-028721-x6f26ahr 1500 17 North North NNP cord-028721-x6f26ahr 1500 18 America America NNP cord-028721-x6f26ahr 1500 19 cases case NNS cord-028721-x6f26ahr 1500 20 . . . cord-028721-x6f26ahr 1501 1 Conversely conversely RB cord-028721-x6f26ahr 1501 2 , , , cord-028721-x6f26ahr 1501 3 most most JJS cord-028721-x6f26ahr 1501 4 African african JJ cord-028721-x6f26ahr 1501 5 true true JJ cord-028721-x6f26ahr 1501 6 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1501 7 ( ( -LRB- cord-028721-x6f26ahr 1501 8 97 97 CD cord-028721-x6f26ahr 1501 9 % % NN cord-028721-x6f26ahr 1501 10 ) ) -RRB- cord-028721-x6f26ahr 1501 11 have have VBP cord-028721-x6f26ahr 1501 12 46XX 46xx CD cord-028721-x6f26ahr 1501 13 karyotype karyotype NN cord-028721-x6f26ahr 1501 14 . . . cord-028721-x6f26ahr 1502 1 The the DT cord-028721-x6f26ahr 1502 2 karyotype karyotype NN cord-028721-x6f26ahr 1502 3 46XY 46xy CD cord-028721-x6f26ahr 1502 4 is be VBZ cord-028721-x6f26ahr 1502 5 rare rare JJ cord-028721-x6f26ahr 1502 6 and and CC cord-028721-x6f26ahr 1502 7 its -PRON- PRP$ cord-028721-x6f26ahr 1502 8 frequency frequency NN cord-028721-x6f26ahr 1502 9 is be VBZ cord-028721-x6f26ahr 1502 10 similar similar JJ cord-028721-x6f26ahr 1502 11 in in IN cord-028721-x6f26ahr 1502 12 Europe Europe NNP cord-028721-x6f26ahr 1502 13 , , , cord-028721-x6f26ahr 1502 14 Asia Asia NNP cord-028721-x6f26ahr 1502 15 , , , cord-028721-x6f26ahr 1502 16 and and CC cord-028721-x6f26ahr 1502 17 North North NNP cord-028721-x6f26ahr 1502 18 America America NNP cord-028721-x6f26ahr 1502 19 . . . cord-028721-x6f26ahr 1503 1 678 678 CD cord-028721-x6f26ahr 1504 1 , , , cord-028721-x6f26ahr 1504 2 679 679 CD cord-028721-x6f26ahr 1504 3 Most Most JJS cord-028721-x6f26ahr 1504 4 cases case NNS cord-028721-x6f26ahr 1504 5 are be VBP cord-028721-x6f26ahr 1504 6 sporadic sporadic JJ cord-028721-x6f26ahr 1504 7 , , , cord-028721-x6f26ahr 1504 8 and and CC cord-028721-x6f26ahr 1504 9 families family NNS cord-028721-x6f26ahr 1504 10 with with IN cord-028721-x6f26ahr 1504 11 several several JJ cord-028721-x6f26ahr 1504 12 affected affect VBN cord-028721-x6f26ahr 1504 13 members member NNS cord-028721-x6f26ahr 1504 14 also also RB cord-028721-x6f26ahr 1504 15 have have VBP cord-028721-x6f26ahr 1504 16 46XX 46xx CD cord-028721-x6f26ahr 1504 17 males male NNS cord-028721-x6f26ahr 1504 18 . . . cord-028721-x6f26ahr 1505 1 This this DT cord-028721-x6f26ahr 1505 2 fi fi NN cord-028721-x6f26ahr 1505 3 nding nding NN cord-028721-x6f26ahr 1505 4 suggests suggest VBZ cord-028721-x6f26ahr 1505 5 that that IN cord-028721-x6f26ahr 1505 6 both both DT cord-028721-x6f26ahr 1505 7 genetic genetic JJ cord-028721-x6f26ahr 1505 8 anomalies anomaly NNS cord-028721-x6f26ahr 1505 9 are be VBP cord-028721-x6f26ahr 1505 10 alternative alternative JJ cord-028721-x6f26ahr 1505 11 forms form NNS cord-028721-x6f26ahr 1505 12 of of IN cord-028721-x6f26ahr 1505 13 a a DT cord-028721-x6f26ahr 1505 14 single single JJ cord-028721-x6f26ahr 1505 15 genetic genetic JJ cord-028721-x6f26ahr 1505 16 defect defect NN cord-028721-x6f26ahr 1505 17 . . . cord-028721-x6f26ahr 1506 1 680 680 CD cord-028721-x6f26ahr 1507 1 The the DT cord-028721-x6f26ahr 1507 2 following follow VBG cord-028721-x6f26ahr 1507 3 mechanisms mechanism NNS cord-028721-x6f26ahr 1507 4 681 681 CD cord-028721-x6f26ahr 1507 5 , , , cord-028721-x6f26ahr 1507 6 682 682 CD cord-028721-x6f26ahr 1507 7 have have VBP cord-028721-x6f26ahr 1507 8 been be VBN cord-028721-x6f26ahr 1507 9 proposed propose VBN cord-028721-x6f26ahr 1507 10 to to TO cord-028721-x6f26ahr 1507 11 explain explain VB cord-028721-x6f26ahr 1507 12 the the DT cord-028721-x6f26ahr 1507 13 occurrence occurrence NN cord-028721-x6f26ahr 1507 14 of of IN cord-028721-x6f26ahr 1507 15 testicular testicular JJ cord-028721-x6f26ahr 1507 16 parenchyma parenchyma NNS cord-028721-x6f26ahr 1507 17 : : : cord-028721-x6f26ahr 1507 18 true true JJ cord-028721-x6f26ahr 1507 19 hermaphroditism hermaphroditism NN cord-028721-x6f26ahr 1507 20 46XX 46xx CD cord-028721-x6f26ahr 1507 21 , , , cord-028721-x6f26ahr 1507 22 a a DT cord-028721-x6f26ahr 1507 23 hidden hide VBN cord-028721-x6f26ahr 1507 24 mosaicism mosaicism NN cord-028721-x6f26ahr 1507 25 with with IN cord-028721-x6f26ahr 1507 26 a a DT cord-028721-x6f26ahr 1507 27 cell cell NN cord-028721-x6f26ahr 1507 28 line line NN cord-028721-x6f26ahr 1507 29 having have VBG cord-028721-x6f26ahr 1507 30 a a DT cord-028721-x6f26ahr 1507 31 Y Y NNP cord-028721-x6f26ahr 1507 32 chromosome chromosome NN cord-028721-x6f26ahr 1507 33 ; ; : cord-028721-x6f26ahr 1507 34 transfer transfer NN cord-028721-x6f26ahr 1507 35 from from IN cord-028721-x6f26ahr 1507 36 a a DT cord-028721-x6f26ahr 1507 37 Y Y NNP cord-028721-x6f26ahr 1507 38 chromosome chromosome NN cord-028721-x6f26ahr 1507 39 fragment fragment NN cord-028721-x6f26ahr 1507 40 ( ( -LRB- cord-028721-x6f26ahr 1507 41 including include VBG cord-028721-x6f26ahr 1507 42 SRY SRY NNP cord-028721-x6f26ahr 1507 43 gene gene NN cord-028721-x6f26ahr 1507 44 ) ) -RRB- cord-028721-x6f26ahr 1507 45 to to IN cord-028721-x6f26ahr 1507 46 the the DT cord-028721-x6f26ahr 1507 47 X x NN cord-028721-x6f26ahr 1507 48 chromosome chromosome NN cord-028721-x6f26ahr 1507 49 ; ; , cord-028721-x6f26ahr 1507 50 autosomal autosomal JJ cord-028721-x6f26ahr 1507 51 mutation mutation NN cord-028721-x6f26ahr 1507 52 of of IN cord-028721-x6f26ahr 1507 53 variable variable JJ cord-028721-x6f26ahr 1507 54 penetrance penetrance NN cord-028721-x6f26ahr 1507 55 ; ; : cord-028721-x6f26ahr 1507 56 and and CC cord-028721-x6f26ahr 1507 57 X X NNS cord-028721-x6f26ahr 1507 58 - - HYPH cord-028721-x6f26ahr 1507 59 linked link VBN cord-028721-x6f26ahr 1507 60 mutation mutation NN cord-028721-x6f26ahr 1507 61 coupled couple VBN cord-028721-x6f26ahr 1507 62 with with IN cord-028721-x6f26ahr 1507 63 rare rare JJ cord-028721-x6f26ahr 1507 64 X x NN cord-028721-x6f26ahr 1507 65 inactivation inactivation NN cord-028721-x6f26ahr 1507 66 or or CC cord-028721-x6f26ahr 1507 67 X x NN cord-028721-x6f26ahr 1507 68 mutation mutation NN cord-028721-x6f26ahr 1507 69 that that WDT cord-028721-x6f26ahr 1507 70 permits permit VBZ cord-028721-x6f26ahr 1507 71 testicular testicular JJ cord-028721-x6f26ahr 1507 72 differentiation differentiation NN cord-028721-x6f26ahr 1507 73 in in IN cord-028721-x6f26ahr 1507 74 the the DT cord-028721-x6f26ahr 1507 75 absence absence NN cord-028721-x6f26ahr 1507 76 of of IN cord-028721-x6f26ahr 1507 77 SRY SRY NNP cord-028721-x6f26ahr 1507 78 . . . cord-028721-x6f26ahr 1508 1 Some some DT cord-028721-x6f26ahr 1508 2 46XX 46xx CD cord-028721-x6f26ahr 1508 3 hermaphrodites hermaphrodites VBP cord-028721-x6f26ahr 1508 4 with with IN cord-028721-x6f26ahr 1508 5 SRY sry JJ cord-028721-x6f26ahr 1508 6 - - HYPH cord-028721-x6f26ahr 1508 7 negative negative JJ cord-028721-x6f26ahr 1508 8 leukocytes leukocyte NNS cord-028721-x6f26ahr 1508 9 are be VBP cord-028721-x6f26ahr 1508 10 positive positive JJ cord-028721-x6f26ahr 1508 11 for for IN cord-028721-x6f26ahr 1508 12 this this DT cord-028721-x6f26ahr 1508 13 gene gene NN cord-028721-x6f26ahr 1508 14 in in IN cord-028721-x6f26ahr 1508 15 DNA DNA NNP cord-028721-x6f26ahr 1508 16 from from IN cord-028721-x6f26ahr 1508 17 the the DT cord-028721-x6f26ahr 1508 18 testicular testicular JJ cord-028721-x6f26ahr 1508 19 parenchyma parenchyma NN cord-028721-x6f26ahr 1508 20 in in IN cord-028721-x6f26ahr 1508 21 the the DT cord-028721-x6f26ahr 1508 22 ovotestis ovotestis NN cord-028721-x6f26ahr 1508 23 . . . cord-028721-x6f26ahr 1509 1 683 683 CD cord-028721-x6f26ahr 1510 1 Over over IN cord-028721-x6f26ahr 1510 2 22 22 CD cord-028721-x6f26ahr 1510 3 pregnancies pregnancy NNS cord-028721-x6f26ahr 1510 4 in in IN cord-028721-x6f26ahr 1510 5 true true JJ cord-028721-x6f26ahr 1510 6 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 1510 7 have have VBP cord-028721-x6f26ahr 1510 8 been be VBN cord-028721-x6f26ahr 1510 9 reported report VBN cord-028721-x6f26ahr 1510 10 , , , cord-028721-x6f26ahr 1510 11 684 684 CD cord-028721-x6f26ahr 1510 12 in in IN cord-028721-x6f26ahr 1510 13 contrast contrast NN cord-028721-x6f26ahr 1510 14 to to IN cord-028721-x6f26ahr 1510 15 the the DT cord-028721-x6f26ahr 1510 16 exceptional exceptional JJ cord-028721-x6f26ahr 1510 17 cases case NNS cord-028721-x6f26ahr 1510 18 of of IN cord-028721-x6f26ahr 1510 19 paternity paternity NN cord-028721-x6f26ahr 1510 20 . . . cord-028721-x6f26ahr 1511 1 Ovules Ovules NNP cord-028721-x6f26ahr 1511 2 may may MD cord-028721-x6f26ahr 1511 3 arise arise VB cord-028721-x6f26ahr 1511 4 from from IN cord-028721-x6f26ahr 1511 5 the the DT cord-028721-x6f26ahr 1511 6 ovotestes ovotestis NNS cord-028721-x6f26ahr 1511 7 or or CC cord-028721-x6f26ahr 1511 8 the the DT cord-028721-x6f26ahr 1511 9 ovary ovary NN cord-028721-x6f26ahr 1511 10 . . . cord-028721-x6f26ahr 1512 1 Management management NN cord-028721-x6f26ahr 1512 2 of of IN cord-028721-x6f26ahr 1512 3 true true JJ cord-028721-x6f26ahr 1512 4 hermaphroditism hermaphroditism NN cord-028721-x6f26ahr 1512 5 depends depend VBZ cord-028721-x6f26ahr 1512 6 on on IN cord-028721-x6f26ahr 1512 7 the the DT cord-028721-x6f26ahr 1512 8 patient patient NN cord-028721-x6f26ahr 1512 9 's 's POS cord-028721-x6f26ahr 1512 10 age age NN cord-028721-x6f26ahr 1512 11 at at IN cord-028721-x6f26ahr 1512 12 the the DT cord-028721-x6f26ahr 1512 13 time time NN cord-028721-x6f26ahr 1512 14 of of IN cord-028721-x6f26ahr 1512 15 diagnosis diagnosis NN cord-028721-x6f26ahr 1512 16 , , , cord-028721-x6f26ahr 1512 17 the the DT cord-028721-x6f26ahr 1512 18 nature nature NN cord-028721-x6f26ahr 1512 19 and and CC cord-028721-x6f26ahr 1512 20 location location NN cord-028721-x6f26ahr 1512 21 of of IN cord-028721-x6f26ahr 1512 22 the the DT cord-028721-x6f26ahr 1512 23 gonads gonad NNS cord-028721-x6f26ahr 1512 24 , , , cord-028721-x6f26ahr 1512 25 and and CC cord-028721-x6f26ahr 1512 26 the the DT cord-028721-x6f26ahr 1512 27 developmental developmental JJ cord-028721-x6f26ahr 1512 28 stage stage NN cord-028721-x6f26ahr 1512 29 of of IN cord-028721-x6f26ahr 1512 30 the the DT cord-028721-x6f26ahr 1512 31 external external JJ cord-028721-x6f26ahr 1512 32 genitalia genitalia NNS cord-028721-x6f26ahr 1512 33 . . . cord-028721-x6f26ahr 1513 1 Although although IN cord-028721-x6f26ahr 1513 2 bilateral bilateral JJ cord-028721-x6f26ahr 1513 3 castration castration NN cord-028721-x6f26ahr 1513 4 may may MD cord-028721-x6f26ahr 1513 5 be be VB cord-028721-x6f26ahr 1513 6 justifi justifi NNP cord-028721-x6f26ahr 1513 7 ed ed NN cord-028721-x6f26ahr 1513 8 in in IN cord-028721-x6f26ahr 1513 9 order order NN cord-028721-x6f26ahr 1513 10 to to TO cord-028721-x6f26ahr 1513 11 avoid avoid VB cord-028721-x6f26ahr 1513 12 the the DT cord-028721-x6f26ahr 1513 13 risk risk NN cord-028721-x6f26ahr 1513 14 of of IN cord-028721-x6f26ahr 1513 15 neoplasia neoplasia NN cord-028721-x6f26ahr 1513 16 , , , cord-028721-x6f26ahr 1513 17 gonadal gonadal JJ cord-028721-x6f26ahr 1513 18 preservation preservation NN cord-028721-x6f26ahr 1513 19 may may MD cord-028721-x6f26ahr 1513 20 be be VB cord-028721-x6f26ahr 1513 21 desirable desirable JJ cord-028721-x6f26ahr 1513 22 until until IN cord-028721-x6f26ahr 1513 23 adulthood adulthood NN cord-028721-x6f26ahr 1513 24 . . . cord-028721-x6f26ahr 1514 1 In in IN cord-028721-x6f26ahr 1514 2 this this DT cord-028721-x6f26ahr 1514 3 case case NN cord-028721-x6f26ahr 1514 4 , , , cord-028721-x6f26ahr 1514 5 if if IN cord-028721-x6f26ahr 1514 6 the the DT cord-028721-x6f26ahr 1514 7 patient patient NN cord-028721-x6f26ahr 1514 8 is be VBZ cord-028721-x6f26ahr 1514 9 raised raise VBN cord-028721-x6f26ahr 1514 10 as as IN cord-028721-x6f26ahr 1514 11 a a DT cord-028721-x6f26ahr 1514 12 girl girl NN cord-028721-x6f26ahr 1514 13 , , , cord-028721-x6f26ahr 1514 14 puberty puberty NN cord-028721-x6f26ahr 1514 15 will will MD cord-028721-x6f26ahr 1514 16 occur occur VB cord-028721-x6f26ahr 1514 17 spontaneously spontaneously RB cord-028721-x6f26ahr 1514 18 and and CC cord-028721-x6f26ahr 1514 19 there there EX cord-028721-x6f26ahr 1514 20 is be VBZ cord-028721-x6f26ahr 1514 21 a a DT cord-028721-x6f26ahr 1514 22 small small JJ cord-028721-x6f26ahr 1514 23 chance chance NN cord-028721-x6f26ahr 1514 24 of of IN cord-028721-x6f26ahr 1514 25 fertility fertility NN cord-028721-x6f26ahr 1514 26 . . . cord-028721-x6f26ahr 1515 1 685 685 CD cord-028721-x6f26ahr 1516 1 However however RB cord-028721-x6f26ahr 1516 2 , , , cord-028721-x6f26ahr 1516 3 the the DT cord-028721-x6f26ahr 1516 4 high high JJ cord-028721-x6f26ahr 1516 5 risk risk NN cord-028721-x6f26ahr 1516 6 of of IN cord-028721-x6f26ahr 1516 7 malignancy malignancy NN cord-028721-x6f26ahr 1516 8 ( ( -LRB- cord-028721-x6f26ahr 1516 9 estimated estimate VBN cord-028721-x6f26ahr 1516 10 at at IN cord-028721-x6f26ahr 1516 11 4.6 4.6 CD cord-028721-x6f26ahr 1516 12 % % NN cord-028721-x6f26ahr 1516 13 ) ) -RRB- cord-028721-x6f26ahr 1516 14 should should MD cord-028721-x6f26ahr 1516 15 be be VB cord-028721-x6f26ahr 1516 16 taken take VBN cord-028721-x6f26ahr 1516 17 into into IN cord-028721-x6f26ahr 1516 18 account account NN cord-028721-x6f26ahr 1516 19 . . . cord-028721-x6f26ahr 1517 1 The the DT cord-028721-x6f26ahr 1517 2 most most RBS cord-028721-x6f26ahr 1517 3 frequent frequent JJ cord-028721-x6f26ahr 1517 4 tumors tumor NNS cord-028721-x6f26ahr 1517 5 are be VBP cord-028721-x6f26ahr 1517 6 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1517 7 , , , cord-028721-x6f26ahr 1517 8 dysgerminoma dysgerminoma NNP cord-028721-x6f26ahr 1517 9 , , , cord-028721-x6f26ahr 1517 10 and and CC cord-028721-x6f26ahr 1517 11 yolk yolk NN cord-028721-x6f26ahr 1517 12 sac sac NN cord-028721-x6f26ahr 1517 13 tumor tumor NN cord-028721-x6f26ahr 1517 14 . . . cord-028721-x6f26ahr 1518 1 676 676 CD cord-028721-x6f26ahr 1519 1 The the DT cord-028721-x6f26ahr 1519 2 risk risk NN cord-028721-x6f26ahr 1519 3 of of IN cord-028721-x6f26ahr 1519 4 cancer cancer NN cord-028721-x6f26ahr 1519 5 may may MD cord-028721-x6f26ahr 1519 6 be be VB cord-028721-x6f26ahr 1519 7 reduced reduce VBN cord-028721-x6f26ahr 1519 8 if if IN cord-028721-x6f26ahr 1519 9 some some DT cord-028721-x6f26ahr 1519 10 precautions precaution NNS cord-028721-x6f26ahr 1519 11 are be VBP cord-028721-x6f26ahr 1519 12 taken take VBN cord-028721-x6f26ahr 1519 13 , , , cord-028721-x6f26ahr 1519 14 including include VBG cord-028721-x6f26ahr 1519 15 removal removal NN cord-028721-x6f26ahr 1519 16 of of IN cord-028721-x6f26ahr 1519 17 the the DT cord-028721-x6f26ahr 1519 18 testis testis NN cord-028721-x6f26ahr 1519 19 if if IN cord-028721-x6f26ahr 1519 20 it -PRON- PRP cord-028721-x6f26ahr 1519 21 has have VBZ cord-028721-x6f26ahr 1519 22 not not RB cord-028721-x6f26ahr 1519 23 descended descend VBN cord-028721-x6f26ahr 1519 24 and and CC cord-028721-x6f26ahr 1519 25 surveillance surveillance NN cord-028721-x6f26ahr 1519 26 of of IN cord-028721-x6f26ahr 1519 27 the the DT cord-028721-x6f26ahr 1519 28 residual residual JJ cord-028721-x6f26ahr 1519 29 gonad gonad NN cord-028721-x6f26ahr 1519 30 with with IN cord-028721-x6f26ahr 1519 31 periodic periodic JJ cord-028721-x6f26ahr 1519 32 ultrasound ultrasound NN cord-028721-x6f26ahr 1519 33 studies study NNS cord-028721-x6f26ahr 1519 34 , , , cord-028721-x6f26ahr 1519 35 especially especially RB cord-028721-x6f26ahr 1519 36 in in IN cord-028721-x6f26ahr 1519 37 cases case NNS cord-028721-x6f26ahr 1519 38 of of IN cord-028721-x6f26ahr 1519 39 chromosomal chromosomal JJ cord-028721-x6f26ahr 1519 40 mosaicisms mosaicism NNS cord-028721-x6f26ahr 1519 41 . . . cord-028721-x6f26ahr 1520 1 Normal normal JJ cord-028721-x6f26ahr 1520 2 male male JJ cord-028721-x6f26ahr 1520 3 development development NN cord-028721-x6f26ahr 1520 4 requires require VBZ cord-028721-x6f26ahr 1520 5 adequate adequate JJ cord-028721-x6f26ahr 1520 6 differentiation differentiation NN cord-028721-x6f26ahr 1520 7 of of IN cord-028721-x6f26ahr 1520 8 the the DT cord-028721-x6f26ahr 1520 9 testes testis NNS cord-028721-x6f26ahr 1520 10 in in IN cord-028721-x6f26ahr 1520 11 the the DT cord-028721-x6f26ahr 1520 12 fetal fetal JJ cord-028721-x6f26ahr 1520 13 period period NN cord-028721-x6f26ahr 1520 14 , , , cord-028721-x6f26ahr 1520 15 synthesis synthesis NN cord-028721-x6f26ahr 1520 16 and and CC cord-028721-x6f26ahr 1520 17 secretion secretion NN cord-028721-x6f26ahr 1520 18 of of IN cord-028721-x6f26ahr 1520 19 testicular testicular JJ cord-028721-x6f26ahr 1520 20 hormones hormone NNS cord-028721-x6f26ahr 1520 21 , , , cord-028721-x6f26ahr 1520 22 and and CC cord-028721-x6f26ahr 1520 23 proper proper JJ cord-028721-x6f26ahr 1520 24 response response NN cord-028721-x6f26ahr 1520 25 of of IN cord-028721-x6f26ahr 1520 26 target target NN cord-028721-x6f26ahr 1520 27 organs organ NNS cord-028721-x6f26ahr 1520 28 to to IN cord-028721-x6f26ahr 1520 29 these these DT cord-028721-x6f26ahr 1520 30 hormones hormone NNS cord-028721-x6f26ahr 1520 31 . . . cord-028721-x6f26ahr 1521 1 Anti anti JJ cord-028721-x6f26ahr 1521 2 - - JJ cord-028721-x6f26ahr 1521 3 müllerian müllerian JJ cord-028721-x6f26ahr 1521 4 hormone hormone NN cord-028721-x6f26ahr 1521 5 produced produce VBN cord-028721-x6f26ahr 1521 6 by by IN cord-028721-x6f26ahr 1521 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 1521 8 cells cell NNS cord-028721-x6f26ahr 1521 9 inhibits inhibit VBZ cord-028721-x6f26ahr 1521 10 the the DT cord-028721-x6f26ahr 1521 11 development development NN cord-028721-x6f26ahr 1521 12 of of IN cord-028721-x6f26ahr 1521 13 müllerian müllerian JJ cord-028721-x6f26ahr 1521 14 derivatives derivative NNS cord-028721-x6f26ahr 1521 15 that that WDT cord-028721-x6f26ahr 1521 16 would would MD cord-028721-x6f26ahr 1521 17 otherwise otherwise RB cord-028721-x6f26ahr 1521 18 form form VB cord-028721-x6f26ahr 1521 19 the the DT cord-028721-x6f26ahr 1521 20 uterus uterus NN cord-028721-x6f26ahr 1521 21 and and CC cord-028721-x6f26ahr 1521 22 fallopian fallopian JJ cord-028721-x6f26ahr 1521 23 tubes tube NNS cord-028721-x6f26ahr 1521 24 . . . cord-028721-x6f26ahr 1522 1 Testosterone testosterone NN cord-028721-x6f26ahr 1522 2 produced produce VBN cord-028721-x6f26ahr 1522 3 by by IN cord-028721-x6f26ahr 1522 4 Leydig Leydig NNP cord-028721-x6f26ahr 1522 5 cells cell NNS cord-028721-x6f26ahr 1522 6 stimulates stimulate VBZ cord-028721-x6f26ahr 1522 7 differentiation differentiation NN cord-028721-x6f26ahr 1522 8 of of IN cord-028721-x6f26ahr 1522 9 the the DT cord-028721-x6f26ahr 1522 10 wolffi wolffi NN cord-028721-x6f26ahr 1522 11 an an DT cord-028721-x6f26ahr 1522 12 ducts duct NNS cord-028721-x6f26ahr 1522 13 into into IN cord-028721-x6f26ahr 1522 14 male male JJ cord-028721-x6f26ahr 1522 15 genital genital JJ cord-028721-x6f26ahr 1522 16 ducts duct NNS cord-028721-x6f26ahr 1522 17 . . . cord-028721-x6f26ahr 1523 1 The the DT cord-028721-x6f26ahr 1523 2 conversion conversion NN cord-028721-x6f26ahr 1523 3 of of IN cord-028721-x6f26ahr 1523 4 testosterone testosterone NN cord-028721-x6f26ahr 1523 5 into into IN cord-028721-x6f26ahr 1523 6 dihydrotestosterone dihydrotestosterone NN cord-028721-x6f26ahr 1523 7 by by IN cord-028721-x6f26ahr 1523 8 the the DT cord-028721-x6f26ahr 1523 9 enzyme enzyme NN cord-028721-x6f26ahr 1523 10 5α 5α CD cord-028721-x6f26ahr 1523 11 - - HYPH cord-028721-x6f26ahr 1523 12 reductase reductase NN cord-028721-x6f26ahr 1523 13 ensures ensure VBZ cord-028721-x6f26ahr 1523 14 the the DT cord-028721-x6f26ahr 1523 15 development development NN cord-028721-x6f26ahr 1523 16 of of IN cord-028721-x6f26ahr 1523 17 male male JJ cord-028721-x6f26ahr 1523 18 external external JJ cord-028721-x6f26ahr 1523 19 genitalia genitalia NNS cord-028721-x6f26ahr 1523 20 . . . cord-028721-x6f26ahr 1524 1 Alterations alteration NNS cord-028721-x6f26ahr 1524 2 in in IN cord-028721-x6f26ahr 1524 3 these these DT cord-028721-x6f26ahr 1524 4 processes process NNS cord-028721-x6f26ahr 1524 5 may may MD cord-028721-x6f26ahr 1524 6 cause cause VB cord-028721-x6f26ahr 1524 7 male male JJ cord-028721-x6f26ahr 1524 8 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1524 9 . . . cord-028721-x6f26ahr 1525 1 Androgen androgen NN cord-028721-x6f26ahr 1525 2 synthesis synthesis NN cord-028721-x6f26ahr 1525 3 defi defi NNP cord-028721-x6f26ahr 1525 4 ciencies ciencies NNP cord-028721-x6f26ahr 1526 1 These these DT cord-028721-x6f26ahr 1526 2 autosomal autosomal JJ cord-028721-x6f26ahr 1526 3 recessive recessive JJ cord-028721-x6f26ahr 1526 4 syndromes syndrome NNS cord-028721-x6f26ahr 1526 5 are be VBP cord-028721-x6f26ahr 1526 6 characterized characterize VBN cord-028721-x6f26ahr 1526 7 by by IN cord-028721-x6f26ahr 1526 8 an an DT cord-028721-x6f26ahr 1526 9 error error NN cord-028721-x6f26ahr 1526 10 in in IN cord-028721-x6f26ahr 1526 11 testosterone testosterone NN cord-028721-x6f26ahr 1526 12 synthesis synthesis NN cord-028721-x6f26ahr 1526 13 that that WDT cord-028721-x6f26ahr 1526 14 results result VBZ cord-028721-x6f26ahr 1526 15 in in IN cord-028721-x6f26ahr 1526 16 incomplete incomplete JJ cord-028721-x6f26ahr 1526 17 or or CC cord-028721-x6f26ahr 1526 18 absent absent JJ cord-028721-x6f26ahr 1526 19 virilization virilization NN cord-028721-x6f26ahr 1526 20 . . . cord-028721-x6f26ahr 1527 1 Cholesterol cholesterol NN cord-028721-x6f26ahr 1527 2 is be VBZ cord-028721-x6f26ahr 1527 3 the the DT cord-028721-x6f26ahr 1527 4 source source NN cord-028721-x6f26ahr 1527 5 for for IN cord-028721-x6f26ahr 1527 6 the the DT cord-028721-x6f26ahr 1527 7 synthesis synthesis NN cord-028721-x6f26ahr 1527 8 of of IN cord-028721-x6f26ahr 1527 9 androgens androgen NNS cord-028721-x6f26ahr 1527 10 , , , cord-028721-x6f26ahr 1527 11 estrogens estrogen NNS cord-028721-x6f26ahr 1527 12 , , , cord-028721-x6f26ahr 1527 13 and and CC cord-028721-x6f26ahr 1527 14 other other JJ cord-028721-x6f26ahr 1527 15 steroid steroid NN cord-028721-x6f26ahr 1527 16 hormones hormone NNS cord-028721-x6f26ahr 1527 17 through through IN cord-028721-x6f26ahr 1527 18 multiple multiple JJ cord-028721-x6f26ahr 1527 19 steps step NNS cord-028721-x6f26ahr 1527 20 . . . cord-028721-x6f26ahr 1528 1 First first RB cord-028721-x6f26ahr 1528 2 , , , cord-028721-x6f26ahr 1528 3 the the DT cord-028721-x6f26ahr 1528 4 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 1528 5 acute acute JJ cord-028721-x6f26ahr 1528 6 regulatory regulatory JJ cord-028721-x6f26ahr 1528 7 protein protein NN cord-028721-x6f26ahr 1528 8 ( ( -LRB- cord-028721-x6f26ahr 1528 9 StAR StAR NNP cord-028721-x6f26ahr 1528 10 ) ) -RRB- cord-028721-x6f26ahr 1528 11 generates generate VBZ cord-028721-x6f26ahr 1528 12 cholesterol cholesterol NN cord-028721-x6f26ahr 1528 13 into into IN cord-028721-x6f26ahr 1528 14 mitochondria mitochondrion NNS cord-028721-x6f26ahr 1528 15 ; ; : cord-028721-x6f26ahr 1528 16 StAR StAR NNP cord-028721-x6f26ahr 1528 17 gene gene NN cord-028721-x6f26ahr 1528 18 mutations mutation NNS cord-028721-x6f26ahr 1528 19 cause cause VBP cord-028721-x6f26ahr 1528 20 congenital congenital JJ cord-028721-x6f26ahr 1528 21 lipoid lipoid JJ cord-028721-x6f26ahr 1528 22 adrenal adrenal JJ cord-028721-x6f26ahr 1528 23 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1528 24 . . . cord-028721-x6f26ahr 1529 1 Second second RB cord-028721-x6f26ahr 1529 2 , , , cord-028721-x6f26ahr 1529 3 within within IN cord-028721-x6f26ahr 1529 4 mitochondria mitochondrion NNS cord-028721-x6f26ahr 1529 5 , , , cord-028721-x6f26ahr 1529 6 the the DT cord-028721-x6f26ahr 1529 7 cholesterol cholesterol NN cord-028721-x6f26ahr 1529 8 sidechain sidechain NN cord-028721-x6f26ahr 1529 9 cleavage cleavage NN cord-028721-x6f26ahr 1529 10 enzyme enzyme NN cord-028721-x6f26ahr 1529 11 P450scc p450scc POS cord-028721-x6f26ahr 1529 12 transforms transform VBZ cord-028721-x6f26ahr 1529 13 cholesterol cholesterol NN cord-028721-x6f26ahr 1529 14 into into IN cord-028721-x6f26ahr 1529 15 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1529 16 ; ; : cord-028721-x6f26ahr 1529 17 a a DT cord-028721-x6f26ahr 1529 18 disorder disorder NN cord-028721-x6f26ahr 1529 19 in in IN cord-028721-x6f26ahr 1529 20 this this DT cord-028721-x6f26ahr 1529 21 enzyme enzyme NN cord-028721-x6f26ahr 1529 22 is be VBZ cord-028721-x6f26ahr 1529 23 rare rare JJ cord-028721-x6f26ahr 1529 24 because because IN cord-028721-x6f26ahr 1529 25 it -PRON- PRP cord-028721-x6f26ahr 1529 26 is be VBZ cord-028721-x6f26ahr 1529 27 highly highly RB cord-028721-x6f26ahr 1529 28 lethal lethal JJ cord-028721-x6f26ahr 1529 29 in in IN cord-028721-x6f26ahr 1529 30 embryonic embryonic JJ cord-028721-x6f26ahr 1529 31 life life NN cord-028721-x6f26ahr 1529 32 . . . cord-028721-x6f26ahr 1530 1 Third third RB cord-028721-x6f26ahr 1530 2 , , , cord-028721-x6f26ahr 1530 3 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1530 4 undergoes undergo VBZ cord-028721-x6f26ahr 1530 5 17α 17α CD cord-028721-x6f26ahr 1530 6 - - HYPH cord-028721-x6f26ahr 1530 7 hydroxylation hydroxylation NN cord-028721-x6f26ahr 1530 8 by by IN cord-028721-x6f26ahr 1530 9 microsomal microsomal NNP cord-028721-x6f26ahr 1530 10 P450c17 P450c17 NNP cord-028721-x6f26ahr 1530 11 ; ; : cord-028721-x6f26ahr 1530 12 defi defi NNP cord-028721-x6f26ahr 1530 13 ciency ciency NNP cord-028721-x6f26ahr 1530 14 in in IN cord-028721-x6f26ahr 1530 15 17α 17α CD cord-028721-x6f26ahr 1530 16 - - HYPH cord-028721-x6f26ahr 1530 17 hydroxylase hydroxylase NN cord-028721-x6f26ahr 1530 18 causes cause VBZ cord-028721-x6f26ahr 1530 19 female female JJ cord-028721-x6f26ahr 1530 20 sexual sexual JJ cord-028721-x6f26ahr 1530 21 infantilism infantilism NN cord-028721-x6f26ahr 1530 22 and and CC cord-028721-x6f26ahr 1530 23 hypertension hypertension NN cord-028721-x6f26ahr 1530 24 . . . cord-028721-x6f26ahr 1531 1 Fourth fourth RB cord-028721-x6f26ahr 1531 2 , , , cord-028721-x6f26ahr 1531 3 17-OH 17-oh CD cord-028721-x6f26ahr 1531 4 - - HYPH cord-028721-x6f26ahr 1531 5 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1531 6 is be VBZ cord-028721-x6f26ahr 1531 7 converted convert VBN cord-028721-x6f26ahr 1531 8 into into IN cord-028721-x6f26ahr 1531 9 DHEA DHEA NNP cord-028721-x6f26ahr 1531 10 by by IN cord-028721-x6f26ahr 1531 11 17,20-lyase 17,20-lyase CD cord-028721-x6f26ahr 1531 12 activity activity NN cord-028721-x6f26ahr 1531 13 of of IN cord-028721-x6f26ahr 1531 14 P450c17 p450c17 NN cord-028721-x6f26ahr 1531 15 . . . cord-028721-x6f26ahr 1532 1 The the DT cord-028721-x6f26ahr 1532 2 ratio ratio NN cord-028721-x6f26ahr 1532 3 of of IN cord-028721-x6f26ahr 1532 4 17,20-lyase 17,20-lyase CD cord-028721-x6f26ahr 1532 5 to to IN cord-028721-x6f26ahr 1532 6 17α 17α CD cord-028721-x6f26ahr 1532 7 - - HYPH cord-028721-x6f26ahr 1532 8 hydroxylase hydroxylase NN cord-028721-x6f26ahr 1532 9 activity activity NN cord-028721-x6f26ahr 1532 10 of of IN cord-028721-x6f26ahr 1532 11 P450c17 p450c17 NN cord-028721-x6f26ahr 1532 12 determines determine VBZ cord-028721-x6f26ahr 1532 13 the the DT cord-028721-x6f26ahr 1532 14 ratio ratio NN cord-028721-x6f26ahr 1532 15 of of IN cord-028721-x6f26ahr 1532 16 C21 C21 NNP cord-028721-x6f26ahr 1532 17 to to IN cord-028721-x6f26ahr 1532 18 C19 C19 NNP cord-028721-x6f26ahr 1532 19 steroids steroid NNS cord-028721-x6f26ahr 1532 20 produced produce VBN cord-028721-x6f26ahr 1532 21 . . . cord-028721-x6f26ahr 1533 1 The the DT cord-028721-x6f26ahr 1533 2 ratio ratio NN cord-028721-x6f26ahr 1533 3 is be VBZ cord-028721-x6f26ahr 1533 4 regulated regulate VBN cord-028721-x6f26ahr 1533 5 by by IN cord-028721-x6f26ahr 1533 6 at at RB cord-028721-x6f26ahr 1533 7 least least RBS cord-028721-x6f26ahr 1533 8 three three CD cord-028721-x6f26ahr 1533 9 factors factor NNS cord-028721-x6f26ahr 1533 10 , , , cord-028721-x6f26ahr 1533 11 including include VBG cord-028721-x6f26ahr 1533 12 the the DT cord-028721-x6f26ahr 1533 13 electrondonating electrondonate VBG cord-028721-x6f26ahr 1533 14 protein protein NN cord-028721-x6f26ahr 1533 15 P450 P450 NNPS cord-028721-x6f26ahr 1533 16 oxidoreductase oxidoreductase NN cord-028721-x6f26ahr 1533 17 ( ( -LRB- cord-028721-x6f26ahr 1533 18 POR POR NNP cord-028721-x6f26ahr 1533 19 ) ) -RRB- cord-028721-x6f26ahr 1533 20 , , , cord-028721-x6f26ahr 1533 21 cytochrome cytochrome NN cord-028721-x6f26ahr 1533 22 b5 b5 NN cord-028721-x6f26ahr 1533 23 , , , cord-028721-x6f26ahr 1533 24 and and CC cord-028721-x6f26ahr 1533 25 serine serine NN cord-028721-x6f26ahr 1533 26 phosphorylation phosphorylation NN cord-028721-x6f26ahr 1533 27 of of IN cord-028721-x6f26ahr 1533 28 P450c17 p450c17 NN cord-028721-x6f26ahr 1533 29 . . . cord-028721-x6f26ahr 1534 1 Mutations mutation NNS cord-028721-x6f26ahr 1534 2 in in IN cord-028721-x6f26ahr 1534 3 POR POR NNP cord-028721-x6f26ahr 1534 4 are be VBP cord-028721-x6f26ahr 1534 5 present present JJ cord-028721-x6f26ahr 1534 6 in in IN cord-028721-x6f26ahr 1534 7 the the DT cord-028721-x6f26ahr 1534 8 Antley Antley NNP cord-028721-x6f26ahr 1534 9 - - HYPH cord-028721-x6f26ahr 1534 10 Bixler Bixler NNP cord-028721-x6f26ahr 1534 11 skeletal skeletal JJ cord-028721-x6f26ahr 1534 12 dysplasia dysplasia NN cord-028721-x6f26ahr 1534 13 syndrome syndrome NN cord-028721-x6f26ahr 1534 14 as as RB cord-028721-x6f26ahr 1534 15 well well RB cord-028721-x6f26ahr 1534 16 as as IN cord-028721-x6f26ahr 1534 17 a a DT cord-028721-x6f26ahr 1534 18 variant variant NN cord-028721-x6f26ahr 1534 19 of of IN cord-028721-x6f26ahr 1534 20 polycystic polycystic JJ cord-028721-x6f26ahr 1534 21 ovarian ovarian JJ cord-028721-x6f26ahr 1534 22 syndrome syndrome NN cord-028721-x6f26ahr 1534 23 . . . cord-028721-x6f26ahr 1535 1 Figure figure NN cord-028721-x6f26ahr 1535 2 12 12 CD cord-028721-x6f26ahr 1535 3 -71 -71 NN cord-028721-x6f26ahr 1535 4 shows show NNS cord-028721-x6f26ahr 1535 5 the the DT cord-028721-x6f26ahr 1535 6 enzymes enzyme NNS cord-028721-x6f26ahr 1535 7 involved involve VBN cord-028721-x6f26ahr 1535 8 in in IN cord-028721-x6f26ahr 1535 9 the the DT cord-028721-x6f26ahr 1535 10 abovementioned abovementioned JJ cord-028721-x6f26ahr 1535 11 steps step NNS cord-028721-x6f26ahr 1535 12 . . . cord-028721-x6f26ahr 1536 1 The the DT cord-028721-x6f26ahr 1536 2 enzyme enzyme NN cord-028721-x6f26ahr 1536 3 3β 3β NN cord-028721-x6f26ahr 1536 4 - - HYPH cord-028721-x6f26ahr 1536 5 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 1536 6 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 1536 7 transforms transform VBZ cord-028721-x6f26ahr 1536 8 DHEA DHEA NNP cord-028721-x6f26ahr 1536 9 to to IN cord-028721-x6f26ahr 1536 10 androstenedione androstenedione NN cord-028721-x6f26ahr 1536 11 , , , cord-028721-x6f26ahr 1536 12 and and CC cord-028721-x6f26ahr 1536 13 the the DT cord-028721-x6f26ahr 1536 14 enzymatic enzymatic JJ cord-028721-x6f26ahr 1536 15 complex complex NN cord-028721-x6f26ahr 1536 16 called call VBN cord-028721-x6f26ahr 1536 17 aromatase aromatase NN cord-028721-x6f26ahr 1536 18 transforms transform VBZ cord-028721-x6f26ahr 1536 19 androstenedione androstenedione NN cord-028721-x6f26ahr 1536 20 into into IN cord-028721-x6f26ahr 1536 21 estrone estrone NN cord-028721-x6f26ahr 1536 22 and and CC cord-028721-x6f26ahr 1536 23 testosterone testosterone NN cord-028721-x6f26ahr 1536 24 into into IN cord-028721-x6f26ahr 1536 25 estradiol estradiol NN cord-028721-x6f26ahr 1536 26 . . . cord-028721-x6f26ahr 1537 1 In in IN cord-028721-x6f26ahr 1537 2 some some DT cord-028721-x6f26ahr 1537 3 patients patient NNS cord-028721-x6f26ahr 1537 4 cholesterol cholesterol NN cord-028721-x6f26ahr 1537 5 synthesis synthesis NN cord-028721-x6f26ahr 1537 6 is be VBZ cord-028721-x6f26ahr 1537 7 also also RB cord-028721-x6f26ahr 1537 8 impaired impaired JJ cord-028721-x6f26ahr 1537 9 , , , cord-028721-x6f26ahr 1537 10 and and CC cord-028721-x6f26ahr 1537 11 congenital congenital JJ cord-028721-x6f26ahr 1537 12 adrenal adrenal JJ cord-028721-x6f26ahr 1537 13 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1537 14 is be VBZ cord-028721-x6f26ahr 1537 15 superimposed superimpose VBN cord-028721-x6f26ahr 1537 16 on on IN cord-028721-x6f26ahr 1537 17 androgen androgen NN cord-028721-x6f26ahr 1537 18 defi defi NNP cord-028721-x6f26ahr 1537 19 ciency ciency NNP cord-028721-x6f26ahr 1537 20 . . . cord-028721-x6f26ahr 1538 1 Defi Defi NNP cord-028721-x6f26ahr 1538 2 cient cient NN cord-028721-x6f26ahr 1538 3 testosterone testosterone NN cord-028721-x6f26ahr 1538 4 synthesis synthesis NN cord-028721-x6f26ahr 1538 5 may may MD cord-028721-x6f26ahr 1538 6 result result VB cord-028721-x6f26ahr 1538 7 from from IN cord-028721-x6f26ahr 1538 8 abnormalities abnormality NNS cord-028721-x6f26ahr 1538 9 in in IN cord-028721-x6f26ahr 1538 10 the the DT cord-028721-x6f26ahr 1538 11 enzymes enzyme NNS cord-028721-x6f26ahr 1538 12 involved involve VBN cord-028721-x6f26ahr 1538 13 in in IN cord-028721-x6f26ahr 1538 14 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1538 15 formation formation NN cord-028721-x6f26ahr 1538 16 ( ( -LRB- cord-028721-x6f26ahr 1538 17 congenital congenital JJ cord-028721-x6f26ahr 1538 18 lipoid lipoid NNP cord-028721-x6f26ahr 1538 19 adrenal adrenal JJ cord-028721-x6f26ahr 1538 20 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1538 21 ) ) -RRB- cord-028721-x6f26ahr 1538 22 , , , cord-028721-x6f26ahr 1538 23 including include VBG cord-028721-x6f26ahr 1538 24 3β 3β NNP cord-028721-x6f26ahr 1538 25 hydroxysteroid hydroxysteroid NNP cord-028721-x6f26ahr 1538 26 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 1538 27 , , , cord-028721-x6f26ahr 1538 28 17αhydroxylase 17αhydroxylase CD cord-028721-x6f26ahr 1538 29 , , , cord-028721-x6f26ahr 1538 30 17,20-desmolase 17,20-desmolase CD cord-028721-x6f26ahr 1538 31 , , , cord-028721-x6f26ahr 1538 32 and and CC cord-028721-x6f26ahr 1538 33 17β 17β NNS cord-028721-x6f26ahr 1538 34 - - HYPH cord-028721-x6f26ahr 1538 35 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 1538 36 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 1538 37 ( ( -LRB- cord-028721-x6f26ahr 1538 38 Fig Fig NNP cord-028721-x6f26ahr 1538 39 . . . cord-028721-x6f26ahr 1538 40 12 12 CD cord-028721-x6f26ahr 1538 41 - - SYM cord-028721-x6f26ahr 1538 42 71 71 CD cord-028721-x6f26ahr 1538 43 ) ) -RRB- cord-028721-x6f26ahr 1538 44 . . . cord-028721-x6f26ahr 1539 1 Congenital congenital JJ cord-028721-x6f26ahr 1539 2 lipoid lipoid NNP cord-028721-x6f26ahr 1540 1 adrenal adrenal JJ cord-028721-x6f26ahr 1540 2 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1540 3 is be VBZ cord-028721-x6f26ahr 1540 4 the the DT cord-028721-x6f26ahr 1540 5 most most RBS cord-028721-x6f26ahr 1540 6 severe severe JJ cord-028721-x6f26ahr 1540 7 form form NN cord-028721-x6f26ahr 1540 8 of of IN cord-028721-x6f26ahr 1540 9 congenital congenital JJ cord-028721-x6f26ahr 1540 10 adrenal adrenal JJ cord-028721-x6f26ahr 1540 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1540 12 . . . cord-028721-x6f26ahr 1541 1 686 686 CD cord-028721-x6f26ahr 1542 1 The the DT cord-028721-x6f26ahr 1542 2 disorder disorder NN cord-028721-x6f26ahr 1542 3 is be VBZ cord-028721-x6f26ahr 1542 4 characterized characterize VBN cord-028721-x6f26ahr 1542 5 by by IN cord-028721-x6f26ahr 1542 6 a a DT cord-028721-x6f26ahr 1542 7 defi defi NNP cord-028721-x6f26ahr 1542 8 cit cit NNP cord-028721-x6f26ahr 1542 9 in in IN cord-028721-x6f26ahr 1542 10 steroid steroid JJ cord-028721-x6f26ahr 1542 11 hormone hormone NN cord-028721-x6f26ahr 1542 12 synthesis synthesis NN cord-028721-x6f26ahr 1542 13 in in IN cord-028721-x6f26ahr 1542 14 the the DT cord-028721-x6f26ahr 1542 15 adrenal adrenal JJ cord-028721-x6f26ahr 1542 16 cortex cortex NNS cord-028721-x6f26ahr 1542 17 and and CC cord-028721-x6f26ahr 1542 18 gonads gonad NNS cord-028721-x6f26ahr 1542 19 , , , cord-028721-x6f26ahr 1542 20 producing produce VBG cord-028721-x6f26ahr 1542 21 a a DT cord-028721-x6f26ahr 1542 22 female female JJ cord-028721-x6f26ahr 1542 23 phenotype phenotype NN cord-028721-x6f26ahr 1542 24 with with IN cord-028721-x6f26ahr 1542 25 severe severe JJ cord-028721-x6f26ahr 1542 26 salt salt NN cord-028721-x6f26ahr 1542 27 - - HYPH cord-028721-x6f26ahr 1542 28 loss loss NN cord-028721-x6f26ahr 1542 29 syndrome syndrome NN cord-028721-x6f26ahr 1542 30 . . . cord-028721-x6f26ahr 1543 1 Conversion conversion NN cord-028721-x6f26ahr 1543 2 of of IN cord-028721-x6f26ahr 1543 3 cholesterol cholesterol NN cord-028721-x6f26ahr 1543 4 to to IN cord-028721-x6f26ahr 1543 5 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1543 6 requires require VBZ cord-028721-x6f26ahr 1543 7 the the DT cord-028721-x6f26ahr 1543 8 enzymes enzyme NNS cord-028721-x6f26ahr 1543 9 20α 20α NNS cord-028721-x6f26ahr 1543 10 - - : cord-028721-x6f26ahr 1543 11 hydroxylase hydroxylase NN cord-028721-x6f26ahr 1543 12 , , , cord-028721-x6f26ahr 1543 13 20,22desmolase 20,22desmolase CD cord-028721-x6f26ahr 1543 14 , , , cord-028721-x6f26ahr 1543 15 and and CC cord-028721-x6f26ahr 1543 16 22α 22α CD cord-028721-x6f26ahr 1543 17 - - HYPH cord-028721-x6f26ahr 1543 18 hydroxylase hydroxylase NN cord-028721-x6f26ahr 1543 19 . . . cord-028721-x6f26ahr 1544 1 Failure failure NN cord-028721-x6f26ahr 1544 2 of of IN cord-028721-x6f26ahr 1544 3 any any DT cord-028721-x6f26ahr 1544 4 of of IN cord-028721-x6f26ahr 1544 5 these these DT cord-028721-x6f26ahr 1544 6 leads lead NNS cord-028721-x6f26ahr 1544 7 to to IN cord-028721-x6f26ahr 1544 8 defi defi NNP cord-028721-x6f26ahr 1544 9 cits cits NNP cord-028721-x6f26ahr 1544 10 in in IN cord-028721-x6f26ahr 1544 11 cortisol cortisol NN cord-028721-x6f26ahr 1544 12 , , , cord-028721-x6f26ahr 1544 13 aldosterone aldosterone NN cord-028721-x6f26ahr 1544 14 , , , cord-028721-x6f26ahr 1544 15 and and CC cord-028721-x6f26ahr 1544 16 testosterone testosterone NN cord-028721-x6f26ahr 1544 17 . . . cord-028721-x6f26ahr 1545 1 687 687 CD cord-028721-x6f26ahr 1546 1 The the DT cord-028721-x6f26ahr 1546 2 enzymatic enzymatic JJ cord-028721-x6f26ahr 1546 3 defect defect NN cord-028721-x6f26ahr 1546 4 is be VBZ cord-028721-x6f26ahr 1546 5 usually usually RB cord-028721-x6f26ahr 1546 6 is be VBZ cord-028721-x6f26ahr 1546 7 caused cause VBN cord-028721-x6f26ahr 1546 8 by by IN cord-028721-x6f26ahr 1546 9 a a DT cord-028721-x6f26ahr 1546 10 defi defi NNP cord-028721-x6f26ahr 1546 11 cit cit NNP cord-028721-x6f26ahr 1546 12 in in IN cord-028721-x6f26ahr 1546 13 the the DT cord-028721-x6f26ahr 1546 14 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 1546 15 acute acute NNP cord-028721-x6f26ahr 1546 16 regulatory regulatory JJ cord-028721-x6f26ahr 1546 17 ( ( -LRB- cord-028721-x6f26ahr 1546 18 StAR StAR NNP cord-028721-x6f26ahr 1546 19 ) ) -RRB- cord-028721-x6f26ahr 1546 20 protein protein NN cord-028721-x6f26ahr 1546 21 ; ; : cord-028721-x6f26ahr 1546 22 in in IN cord-028721-x6f26ahr 1546 23 other other JJ cord-028721-x6f26ahr 1546 24 cases case NNS cord-028721-x6f26ahr 1546 25 , , , cord-028721-x6f26ahr 1546 26 the the DT cord-028721-x6f26ahr 1546 27 defi defi NNP cord-028721-x6f26ahr 1546 28 cit cit NNP cord-028721-x6f26ahr 1546 29 is be VBZ cord-028721-x6f26ahr 1546 30 in in IN cord-028721-x6f26ahr 1546 31 P450ssc P450ssc NNS cord-028721-x6f26ahr 1546 32 . . . cord-028721-x6f26ahr 1547 1 The the DT cord-028721-x6f26ahr 1547 2 mitochondrial mitochondrial JJ cord-028721-x6f26ahr 1547 3 protein protein NN cord-028721-x6f26ahr 1547 4 StAR StAR NNP cord-028721-x6f26ahr 1547 5 promotes promote VBZ cord-028721-x6f26ahr 1547 6 cholesterol cholesterol NN cord-028721-x6f26ahr 1547 7 transfer transfer NN cord-028721-x6f26ahr 1547 8 from from IN cord-028721-x6f26ahr 1547 9 the the DT cord-028721-x6f26ahr 1547 10 outer outer NN cord-028721-x6f26ahr 1547 11 to to IN cord-028721-x6f26ahr 1547 12 inner inner JJ cord-028721-x6f26ahr 1547 13 mitochondrial mitochondrial NN cord-028721-x6f26ahr 1547 14 membrane membrane NN cord-028721-x6f26ahr 1547 15 , , , cord-028721-x6f26ahr 1547 16 where where WRB cord-028721-x6f26ahr 1547 17 cholesterol cholesterol NN cord-028721-x6f26ahr 1547 18 serves serve VBZ cord-028721-x6f26ahr 1547 19 as as IN cord-028721-x6f26ahr 1547 20 a a DT cord-028721-x6f26ahr 1547 21 substrate substrate NN cord-028721-x6f26ahr 1547 22 for for IN cord-028721-x6f26ahr 1547 23 P450scc P450scc NNS cord-028721-x6f26ahr 1547 24 and and CC cord-028721-x6f26ahr 1547 25 initiates initiate VBZ cord-028721-x6f26ahr 1547 26 steroidogenesis steroidogenesis NN cord-028721-x6f26ahr 1547 27 . . . cord-028721-x6f26ahr 1548 1 More More JJR cord-028721-x6f26ahr 1548 2 than than IN cord-028721-x6f26ahr 1548 3 35 35 CD cord-028721-x6f26ahr 1548 4 different different JJ cord-028721-x6f26ahr 1548 5 mutations mutation NNS cord-028721-x6f26ahr 1548 6 in in IN cord-028721-x6f26ahr 1548 7 the the DT cord-028721-x6f26ahr 1548 8 StAR StAR NNP cord-028721-x6f26ahr 1548 9 gene gene NN cord-028721-x6f26ahr 1548 10 have have VBP cord-028721-x6f26ahr 1548 11 been be VBN cord-028721-x6f26ahr 1548 12 identifi identifi VBN cord-028721-x6f26ahr 1548 13 ed ed NN cord-028721-x6f26ahr 1548 14 . . . cord-028721-x6f26ahr 1549 1 690 690 CD cord-028721-x6f26ahr 1550 1 As as IN cord-028721-x6f26ahr 1550 2 a a DT cord-028721-x6f26ahr 1550 3 result result NN cord-028721-x6f26ahr 1550 4 , , , cord-028721-x6f26ahr 1550 5 cholesterol cholesterol NN cord-028721-x6f26ahr 1550 6 is be VBZ cord-028721-x6f26ahr 1550 7 not not RB cord-028721-x6f26ahr 1550 8 converted convert VBN cord-028721-x6f26ahr 1550 9 to to IN cord-028721-x6f26ahr 1550 10 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1550 11 , , , cord-028721-x6f26ahr 1550 12 which which WDT cord-028721-x6f26ahr 1550 13 is be VBZ cord-028721-x6f26ahr 1550 14 required require VBN cord-028721-x6f26ahr 1550 15 for for IN cord-028721-x6f26ahr 1550 16 the the DT cord-028721-x6f26ahr 1550 17 synthesis synthesis NN cord-028721-x6f26ahr 1550 18 of of IN cord-028721-x6f26ahr 1550 19 mineralocorticoids mineralocorticoids NNP cord-028721-x6f26ahr 1550 20 , , , cord-028721-x6f26ahr 1550 21 glucocorticoids glucocorticoid NNS cord-028721-x6f26ahr 1550 22 , , , cord-028721-x6f26ahr 1550 23 and and CC cord-028721-x6f26ahr 1550 24 sex sex NN cord-028721-x6f26ahr 1550 25 hormones hormone NNS cord-028721-x6f26ahr 1550 26 . . . cord-028721-x6f26ahr 1551 1 The the DT cord-028721-x6f26ahr 1551 2 disorder disorder NN cord-028721-x6f26ahr 1551 3 is be VBZ cord-028721-x6f26ahr 1551 4 rare rare JJ cord-028721-x6f26ahr 1551 5 in in IN cord-028721-x6f26ahr 1551 6 most most JJS cord-028721-x6f26ahr 1551 7 countries country NNS cord-028721-x6f26ahr 1551 8 , , , cord-028721-x6f26ahr 1551 9 but but CC cord-028721-x6f26ahr 1551 10 is be VBZ cord-028721-x6f26ahr 1551 11 common common JJ cord-028721-x6f26ahr 1551 12 in in IN cord-028721-x6f26ahr 1551 13 Japan Japan NNP cord-028721-x6f26ahr 1551 14 , , , cord-028721-x6f26ahr 1551 15 Korea Korea NNP cord-028721-x6f26ahr 1551 16 , , , cord-028721-x6f26ahr 1551 17 and and CC cord-028721-x6f26ahr 1551 18 the the DT cord-028721-x6f26ahr 1551 19 Arabian arabian JJ cord-028721-x6f26ahr 1551 20 countries country NNS cord-028721-x6f26ahr 1551 21 . . . cord-028721-x6f26ahr 1552 1 691 691 CD cord-028721-x6f26ahr 1552 2 , , , cord-028721-x6f26ahr 1552 3 692 692 CD cord-028721-x6f26ahr 1552 4 Patients patient NNS cord-028721-x6f26ahr 1552 5 usually usually RB cord-028721-x6f26ahr 1552 6 present present JJ cord-028721-x6f26ahr 1552 7 with with IN cord-028721-x6f26ahr 1552 8 salt salt NN cord-028721-x6f26ahr 1552 9 - - HYPH cord-028721-x6f26ahr 1552 10 losing lose VBG cord-028721-x6f26ahr 1552 11 crisis crisis NN cord-028721-x6f26ahr 1552 12 in in IN cord-028721-x6f26ahr 1552 13 the the DT cord-028721-x6f26ahr 1552 14 fi fi NN cord-028721-x6f26ahr 1552 15 rst rst NNP cord-028721-x6f26ahr 1552 16 2 2 CD cord-028721-x6f26ahr 1552 17 months month NNS cord-028721-x6f26ahr 1552 18 of of IN cord-028721-x6f26ahr 1552 19 life life NN cord-028721-x6f26ahr 1552 20 . . . cord-028721-x6f26ahr 1553 1 693 693 CD cord-028721-x6f26ahr 1554 1 , , , cord-028721-x6f26ahr 1554 2 694 694 CD cord-028721-x6f26ahr 1555 1 In in IN cord-028721-x6f26ahr 1555 2 most most JJS cord-028721-x6f26ahr 1555 3 cases case NNS cord-028721-x6f26ahr 1555 4 , , , cord-028721-x6f26ahr 1555 5 males male NNS cord-028721-x6f26ahr 1555 6 have have VBP cord-028721-x6f26ahr 1555 7 female female JJ cord-028721-x6f26ahr 1555 8 or or CC cord-028721-x6f26ahr 1555 9 ambiguous ambiguous JJ cord-028721-x6f26ahr 1555 10 external external JJ cord-028721-x6f26ahr 1555 11 genitalia genitalia NNS cord-028721-x6f26ahr 1555 12 and and CC cord-028721-x6f26ahr 1555 13 a a DT cord-028721-x6f26ahr 1555 14 blind blind JJ cord-028721-x6f26ahr 1555 15 - - HYPH cord-028721-x6f26ahr 1555 16 sac sac NN cord-028721-x6f26ahr 1555 17 vagina vagina NN cord-028721-x6f26ahr 1555 18 , , , cord-028721-x6f26ahr 1555 19 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1555 20 wolffi wolffi NN cord-028721-x6f26ahr 1556 1 an an DT cord-028721-x6f26ahr 1556 2 derivatives derivative NNS cord-028721-x6f26ahr 1556 3 , , , cord-028721-x6f26ahr 1556 4 absence absence NN cord-028721-x6f26ahr 1556 5 of of IN cord-028721-x6f26ahr 1556 6 müllerian müllerian JJ cord-028721-x6f26ahr 1556 7 structures structure NNS cord-028721-x6f26ahr 1556 8 , , , cord-028721-x6f26ahr 1556 9 and and CC cord-028721-x6f26ahr 1556 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1556 11 . . . cord-028721-x6f26ahr 1557 1 695 695 CD cord-028721-x6f26ahr 1558 1 The the DT cord-028721-x6f26ahr 1558 2 adrenals adrenal NNS cord-028721-x6f26ahr 1558 3 usually usually RB cord-028721-x6f26ahr 1558 4 appear appear VBP cord-028721-x6f26ahr 1558 5 enlarged enlarge VBN cord-028721-x6f26ahr 1558 6 and and CC cord-028721-x6f26ahr 1558 7 contain contain VBP cord-028721-x6f26ahr 1558 8 lipid lipid NN cord-028721-x6f26ahr 1558 9 accumulations accumulation NNS cord-028721-x6f26ahr 1558 10 , , , cord-028721-x6f26ahr 1558 11 696,697 696,697 CD cord-028721-x6f26ahr 1558 12 but but CC cord-028721-x6f26ahr 1558 13 these these DT cord-028721-x6f26ahr 1558 14 diminish diminish VBP cord-028721-x6f26ahr 1558 15 with with IN cord-028721-x6f26ahr 1558 16 age age NN cord-028721-x6f26ahr 1558 17 and and CC cord-028721-x6f26ahr 1558 18 the the DT cord-028721-x6f26ahr 1558 19 adrenals adrenal NNS cord-028721-x6f26ahr 1558 20 shrink shrink VBP cord-028721-x6f26ahr 1558 21 . . . cord-028721-x6f26ahr 1559 1 In in IN cord-028721-x6f26ahr 1559 2 the the DT cord-028721-x6f26ahr 1559 3 testes testis NNS cord-028721-x6f26ahr 1559 4 , , , cord-028721-x6f26ahr 1559 5 lipid lipid NN cord-028721-x6f26ahr 1559 6 accumulations accumulation NNS cord-028721-x6f26ahr 1559 7 may may MD cord-028721-x6f26ahr 1559 8 be be VB cord-028721-x6f26ahr 1559 9 present present JJ cord-028721-x6f26ahr 1559 10 or or CC cord-028721-x6f26ahr 1559 11 absent absent JJ cord-028721-x6f26ahr 1559 12 in in IN cord-028721-x6f26ahr 1559 13 Leydig Leydig NNP cord-028721-x6f26ahr 1559 14 cells cell NNS cord-028721-x6f26ahr 1559 15 686 686 CD cord-028721-x6f26ahr 1559 16 , , , cord-028721-x6f26ahr 1559 17 696 696 CD cord-028721-x6f26ahr 1559 18 , , , cord-028721-x6f26ahr 1559 19 [ [ -LRB- cord-028721-x6f26ahr 1559 20 698 698 CD cord-028721-x6f26ahr 1559 21 ] ] -RRB- cord-028721-x6f26ahr 1559 22 [ [ -LRB- cord-028721-x6f26ahr 1559 23 699 699 CD cord-028721-x6f26ahr 1559 24 ] ] -RRB- cord-028721-x6f26ahr 1559 25 [ [ -LRB- cord-028721-x6f26ahr 1559 26 700 700 CD cord-028721-x6f26ahr 1559 27 ] ] -RRB- cord-028721-x6f26ahr 1559 28 [ [ -LRB- cord-028721-x6f26ahr 1559 29 701 701 CD cord-028721-x6f26ahr 1559 30 ] ] -RRB- cord-028721-x6f26ahr 1559 31 [ [ -LRB- cord-028721-x6f26ahr 1559 32 702 702 CD cord-028721-x6f26ahr 1559 33 ] ] -RRB- cord-028721-x6f26ahr 1559 34 or or CC cord-028721-x6f26ahr 1559 35 Sertoli Sertoli NNP cord-028721-x6f26ahr 1559 36 cells cell NNS cord-028721-x6f26ahr 1559 37 . . . cord-028721-x6f26ahr 1560 1 703 703 CD cord-028721-x6f26ahr 1561 1 An an DT cord-028721-x6f26ahr 1561 2 8-year 8-year JJ cord-028721-x6f26ahr 1561 3 - - HYPH cord-028721-x6f26ahr 1561 4 old old JJ cord-028721-x6f26ahr 1561 5 child child NN cord-028721-x6f26ahr 1561 6 had have VBD cord-028721-x6f26ahr 1561 7 partially partially RB cord-028721-x6f26ahr 1561 8 hyalinized hyalinize VBN cord-028721-x6f26ahr 1561 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 1561 10 tubules tubule NNS cord-028721-x6f26ahr 1561 11 with with IN cord-028721-x6f26ahr 1561 12 Sertoli sertoli JJ cord-028721-x6f26ahr 1561 13 cell cell NN cord-028721-x6f26ahr 1561 14 - - HYPH cord-028721-x6f26ahr 1561 15 only only RB cord-028721-x6f26ahr 1561 16 pattern pattern NN cord-028721-x6f26ahr 1561 17 . . . cord-028721-x6f26ahr 1562 1 704 704 CD cord-028721-x6f26ahr 1563 1 The the DT cord-028721-x6f26ahr 1563 2 testes testis NNS cord-028721-x6f26ahr 1563 3 of of IN cord-028721-x6f26ahr 1563 4 pubertal pubertal JJ cord-028721-x6f26ahr 1563 5 patients patient NNS cord-028721-x6f26ahr 1563 6 are be VBP cord-028721-x6f26ahr 1563 7 usually usually RB cord-028721-x6f26ahr 1563 8 normal normal JJ cord-028721-x6f26ahr 1563 9 for for IN cord-028721-x6f26ahr 1563 10 age age NN cord-028721-x6f26ahr 1563 11 . . . cord-028721-x6f26ahr 1564 1 701 701 CD cord-028721-x6f26ahr 1564 2 , , , cord-028721-x6f26ahr 1564 3 702 702 CD cord-028721-x6f26ahr 1564 4 Intratubular Intratubular NNP cord-028721-x6f26ahr 1564 5 germ germ NN cord-028721-x6f26ahr 1564 6 cell cell NN cord-028721-x6f26ahr 1564 7 neoplasia neoplasia NN cord-028721-x6f26ahr 1564 8 has have VBZ cord-028721-x6f26ahr 1564 9 been be VBN cord-028721-x6f26ahr 1564 10 reported report VBN cord-028721-x6f26ahr 1564 11 in in IN cord-028721-x6f26ahr 1564 12 one one CD cord-028721-x6f26ahr 1564 13 case case NN cord-028721-x6f26ahr 1564 14 . . . cord-028721-x6f26ahr 1565 1 705 705 CD cord-028721-x6f26ahr 1566 1 Most Most JJS cord-028721-x6f26ahr 1566 2 patients patient NNS cord-028721-x6f26ahr 1566 3 die die VBP cord-028721-x6f26ahr 1566 4 from from IN cord-028721-x6f26ahr 1566 5 adrenal adrenal JJ cord-028721-x6f26ahr 1566 6 insuffi insuffi NNP cord-028721-x6f26ahr 1566 7 ciency ciency NNP cord-028721-x6f26ahr 1566 8 . . . cord-028721-x6f26ahr 1567 1 Survivors survivor NNS cord-028721-x6f26ahr 1567 2 have have VBP cord-028721-x6f26ahr 1567 3 female female JJ cord-028721-x6f26ahr 1567 4 phenotype phenotype NN cord-028721-x6f26ahr 1567 5 704 704 CD cord-028721-x6f26ahr 1567 6 and and CC cord-028721-x6f26ahr 1567 7 require require VB cord-028721-x6f26ahr 1567 8 the the DT cord-028721-x6f26ahr 1567 9 administration administration NN cord-028721-x6f26ahr 1567 10 of of IN cord-028721-x6f26ahr 1567 11 glucocorticoids glucocorticoids NNP cord-028721-x6f26ahr 1567 12 , , , cord-028721-x6f26ahr 1567 13 mineralocorticoids mineralocorticoids NNP cord-028721-x6f26ahr 1567 14 , , , cord-028721-x6f26ahr 1567 15 and and CC cord-028721-x6f26ahr 1567 16 gonadal gonadal JJ cord-028721-x6f26ahr 1567 17 steroids steroid NNS cord-028721-x6f26ahr 1567 18 . . . cord-028721-x6f26ahr 1568 1 703 703 CD cord-028721-x6f26ahr 1569 1 3β 3β CD cord-028721-x6f26ahr 1569 2 - - : cord-028721-x6f26ahr 1569 3 Hydroxysteroid hydroxysteroid JJ cord-028721-x6f26ahr 1569 4 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 1569 5 defi defi XX cord-028721-x6f26ahr 1569 6 ciency ciency NN cord-028721-x6f26ahr 1569 7 Patients patient NNS cord-028721-x6f26ahr 1569 8 with with IN cord-028721-x6f26ahr 1569 9 this this DT cord-028721-x6f26ahr 1569 10 defect defect NN cord-028721-x6f26ahr 1569 11 have have VBP cord-028721-x6f26ahr 1569 12 two two CD cord-028721-x6f26ahr 1569 13 main main JJ cord-028721-x6f26ahr 1569 14 problems problem NNS cord-028721-x6f26ahr 1569 15 : : : cord-028721-x6f26ahr 1569 16 salt salt NN cord-028721-x6f26ahr 1569 17 - - HYPH cord-028721-x6f26ahr 1569 18 loss loss NN cord-028721-x6f26ahr 1569 19 syndrome syndrome NN cord-028721-x6f26ahr 1569 20 produced produce VBN cord-028721-x6f26ahr 1569 21 by by IN cord-028721-x6f26ahr 1569 22 reduced reduce VBN cord-028721-x6f26ahr 1569 23 aldosterone aldosterone NN cord-028721-x6f26ahr 1569 24 secretion secretion NN cord-028721-x6f26ahr 1569 25 , , , cord-028721-x6f26ahr 1569 26 and and CC cord-028721-x6f26ahr 1569 27 incomplete incomplete JJ cord-028721-x6f26ahr 1569 28 virilization virilization NN cord-028721-x6f26ahr 1569 29 . . . cord-028721-x6f26ahr 1570 1 706 706 CD cord-028721-x6f26ahr 1571 1 At at IN cord-028721-x6f26ahr 1571 2 puberty puberty NN cord-028721-x6f26ahr 1571 3 , , , cord-028721-x6f26ahr 1571 4 virilization virilization NN cord-028721-x6f26ahr 1571 5 increases increase NNS cord-028721-x6f26ahr 1571 6 and and CC cord-028721-x6f26ahr 1571 7 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1571 8 develops develop VBZ cord-028721-x6f26ahr 1571 9 . . . cord-028721-x6f26ahr 1572 1 707 707 CD cord-028721-x6f26ahr 1572 2 , , , cord-028721-x6f26ahr 1572 3 708 708 CD cord-028721-x6f26ahr 1573 1 The the DT cord-028721-x6f26ahr 1573 2 enzyme enzyme NN cord-028721-x6f26ahr 1573 3 3BHSD 3bhsd CD cord-028721-x6f26ahr 1573 4 catalyzes catalyze VBZ cord-028721-x6f26ahr 1573 5 the the DT cord-028721-x6f26ahr 1573 6 conversion conversion NN cord-028721-x6f26ahr 1573 7 of of IN cord-028721-x6f26ahr 1573 8 5 5 CD cord-028721-x6f26ahr 1573 9 - - SYM cord-028721-x6f26ahr 1573 10 3βhydroxysteroids 3βhydroxysteroids CD cord-028721-x6f26ahr 1573 11 such such JJ cord-028721-x6f26ahr 1573 12 as as IN cord-028721-x6f26ahr 1573 13 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1573 14 , , , cord-028721-x6f26ahr 1573 15 17-hydroxypregnenolone 17-hydroxypregnenolone CD cord-028721-x6f26ahr 1573 16 , , , cord-028721-x6f26ahr 1573 17 and and CC cord-028721-x6f26ahr 1573 18 dehydroepiandrosterone dehydroepiandrosterone NN cord-028721-x6f26ahr 1573 19 into into IN cord-028721-x6f26ahr 1573 20 respectively respectively RB cord-028721-x6f26ahr 1573 21 4 4 CD cord-028721-x6f26ahr 1573 22 - - HYPH cord-028721-x6f26ahr 1573 23 3β 3β CD cord-028721-x6f26ahr 1573 24 - - HYPH cord-028721-x6f26ahr 1573 25 ketosteroid ketosteroid NNP cord-028721-x6f26ahr 1573 26 , , , cord-028721-x6f26ahr 1573 27 progesterone progesterone NN cord-028721-x6f26ahr 1573 28 , , , cord-028721-x6f26ahr 1573 29 17-hydroxyprogesterone 17-hydroxyprogesterone CD cord-028721-x6f26ahr 1573 30 , , , cord-028721-x6f26ahr 1573 31 and and CC cord-028721-x6f26ahr 1573 32 androstenedione androstenedione NN cord-028721-x6f26ahr 1573 33 . . . cord-028721-x6f26ahr 1574 1 709 709 CD cord-028721-x6f26ahr 1575 1 There there EX cord-028721-x6f26ahr 1575 2 are be VBP cord-028721-x6f26ahr 1575 3 two two CD cord-028721-x6f26ahr 1575 4 3BHSD 3bhsd CD cord-028721-x6f26ahr 1575 5 genes gene NNS cord-028721-x6f26ahr 1575 6 located locate VBN cord-028721-x6f26ahr 1575 7 on on IN cord-028721-x6f26ahr 1575 8 the the DT cord-028721-x6f26ahr 1575 9 p11-p13 p11-p13 NNP cord-028721-x6f26ahr 1575 10 region region NN cord-028721-x6f26ahr 1575 11 of of IN cord-028721-x6f26ahr 1575 12 chromosome chromosome NN cord-028721-x6f26ahr 1575 13 1 1 CD cord-028721-x6f26ahr 1575 14 . . . cord-028721-x6f26ahr 1576 1 The the DT cord-028721-x6f26ahr 1576 2 type type NN cord-028721-x6f26ahr 1576 3 I -PRON- PRP cord-028721-x6f26ahr 1576 4 gene gene NN cord-028721-x6f26ahr 1576 5 is be VBZ cord-028721-x6f26ahr 1576 6 expressed express VBN cord-028721-x6f26ahr 1576 7 in in IN cord-028721-x6f26ahr 1576 8 the the DT cord-028721-x6f26ahr 1576 9 placenta placenta NN cord-028721-x6f26ahr 1576 10 , , , cord-028721-x6f26ahr 1576 11 kidney kidney NN cord-028721-x6f26ahr 1576 12 , , , cord-028721-x6f26ahr 1576 13 and and CC cord-028721-x6f26ahr 1576 14 skin skin NN cord-028721-x6f26ahr 1576 15 , , , cord-028721-x6f26ahr 1576 16 whereas whereas IN cord-028721-x6f26ahr 1576 17 the the DT cord-028721-x6f26ahr 1576 18 type type NN cord-028721-x6f26ahr 1576 19 II II NNP cord-028721-x6f26ahr 1576 20 gene gene NN cord-028721-x6f26ahr 1576 21 3BHSD 3BHSD NNP cord-028721-x6f26ahr 1576 22 is be VBZ cord-028721-x6f26ahr 1576 23 expressed express VBN cord-028721-x6f26ahr 1576 24 only only RB cord-028721-x6f26ahr 1576 25 in in IN cord-028721-x6f26ahr 1576 26 the the DT cord-028721-x6f26ahr 1576 27 gonads gonad NNS cord-028721-x6f26ahr 1576 28 and and CC cord-028721-x6f26ahr 1576 29 adrenal adrenal JJ cord-028721-x6f26ahr 1576 30 glands gland NNS cord-028721-x6f26ahr 1576 31 . . . cord-028721-x6f26ahr 1577 1 Complete complete JJ cord-028721-x6f26ahr 1577 2 absence absence NN cord-028721-x6f26ahr 1577 3 of of IN cord-028721-x6f26ahr 1577 4 the the DT cord-028721-x6f26ahr 1577 5 3BHSD 3bhsd CD cord-028721-x6f26ahr 1577 6 gene gene NN cord-028721-x6f26ahr 1577 7 is be VBZ cord-028721-x6f26ahr 1577 8 lethal lethal JJ cord-028721-x6f26ahr 1577 9 ; ; : cord-028721-x6f26ahr 1577 10 therefore therefore RB cord-028721-x6f26ahr 1577 11 , , , cord-028721-x6f26ahr 1577 12 most most RBS cord-028721-x6f26ahr 1577 13 reported report VBN cord-028721-x6f26ahr 1577 14 cases case NNS cord-028721-x6f26ahr 1577 15 have have VBP cord-028721-x6f26ahr 1577 16 only only RB cord-028721-x6f26ahr 1577 17 partial partial JJ cord-028721-x6f26ahr 1577 18 3BHSD 3bhsd CD cord-028721-x6f26ahr 1577 19 deficits deficit NNS cord-028721-x6f26ahr 1577 20 . . . cord-028721-x6f26ahr 1578 1 [ [ -LRB- cord-028721-x6f26ahr 1578 2 710 710 CD cord-028721-x6f26ahr 1578 3 ] ] -RRB- cord-028721-x6f26ahr 1578 4 [ [ -LRB- cord-028721-x6f26ahr 1578 5 711 711 CD cord-028721-x6f26ahr 1578 6 ] ] -RRB- cord-028721-x6f26ahr 1578 7 [ [ -LRB- cord-028721-x6f26ahr 1578 8 712 712 CD cord-028721-x6f26ahr 1578 9 ] ] -RRB- cord-028721-x6f26ahr 1579 1 It -PRON- PRP cord-028721-x6f26ahr 1579 2 is be VBZ cord-028721-x6f26ahr 1579 3 assumed assume VBN cord-028721-x6f26ahr 1579 4 that that IN cord-028721-x6f26ahr 1579 5 these these DT cord-028721-x6f26ahr 1579 6 defi defi NNP cord-028721-x6f26ahr 1579 7 cits cits NNP cord-028721-x6f26ahr 1579 8 account account VBP cord-028721-x6f26ahr 1579 9 for for IN cord-028721-x6f26ahr 1579 10 10 10 CD cord-028721-x6f26ahr 1579 11 % % NN cord-028721-x6f26ahr 1579 12 of of IN cord-028721-x6f26ahr 1579 13 cases case NNS cord-028721-x6f26ahr 1579 14 of of IN cord-028721-x6f26ahr 1579 15 congenital congenital JJ cord-028721-x6f26ahr 1579 16 adrenal adrenal JJ cord-028721-x6f26ahr 1579 17 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1579 18 . . . cord-028721-x6f26ahr 1580 1 The the DT cord-028721-x6f26ahr 1580 2 classic classic JJ cord-028721-x6f26ahr 1580 3 form form NN cord-028721-x6f26ahr 1580 4 of of IN cord-028721-x6f26ahr 1580 5 salt salt NN cord-028721-x6f26ahr 1580 6 - - HYPH cord-028721-x6f26ahr 1580 7 losing lose VBG cord-028721-x6f26ahr 1580 8 3BHSD 3bhsd CD cord-028721-x6f26ahr 1580 9 defi defi NNP cord-028721-x6f26ahr 1580 10 cit cit NNP cord-028721-x6f26ahr 1580 11 is be VBZ cord-028721-x6f26ahr 1580 12 diagnosed diagnose VBN cord-028721-x6f26ahr 1580 13 in in IN cord-028721-x6f26ahr 1580 14 the the DT cord-028721-x6f26ahr 1580 15 fi fi NNP cord-028721-x6f26ahr 1580 16 rst rst NNP cord-028721-x6f26ahr 1580 17 months month NNS cord-028721-x6f26ahr 1580 18 of of IN cord-028721-x6f26ahr 1580 19 life life NN cord-028721-x6f26ahr 1580 20 because because IN cord-028721-x6f26ahr 1580 21 of of IN cord-028721-x6f26ahr 1580 22 insuffi insuffi NNP cord-028721-x6f26ahr 1580 23 cient cient NNP cord-028721-x6f26ahr 1580 24 aldosterone aldosterone NNP cord-028721-x6f26ahr 1580 25 synthesis synthesis NNP cord-028721-x6f26ahr 1580 26 and and CC cord-028721-x6f26ahr 1580 27 subsequent subsequent JJ cord-028721-x6f26ahr 1580 28 loss loss NN cord-028721-x6f26ahr 1580 29 of of IN cord-028721-x6f26ahr 1580 30 salt salt NN cord-028721-x6f26ahr 1580 31 . . . cord-028721-x6f26ahr 1581 1 The the DT cord-028721-x6f26ahr 1581 2 other other JJ cord-028721-x6f26ahr 1581 3 3BHSD 3bhsd CD cord-028721-x6f26ahr 1581 4 defi defi NNP cord-028721-x6f26ahr 1581 5 cit cit NNP cord-028721-x6f26ahr 1581 6 , , , cord-028721-x6f26ahr 1581 7 without without IN cord-028721-x6f26ahr 1581 8 salt salt NN cord-028721-x6f26ahr 1581 9 loss loss NN cord-028721-x6f26ahr 1581 10 , , , cord-028721-x6f26ahr 1581 11 is be VBZ cord-028721-x6f26ahr 1581 12 due due JJ cord-028721-x6f26ahr 1581 13 to to IN cord-028721-x6f26ahr 1581 14 mutations mutation NNS cord-028721-x6f26ahr 1581 15 in in IN cord-028721-x6f26ahr 1581 16 the the DT cord-028721-x6f26ahr 1581 17 type type NN cord-028721-x6f26ahr 1581 18 II II NNP cord-028721-x6f26ahr 1581 19 3BHSD 3bhsd CD cord-028721-x6f26ahr 1581 20 gene gene NN cord-028721-x6f26ahr 1581 21 708 708 CD cord-028721-x6f26ahr 1581 22 and and CC cord-028721-x6f26ahr 1581 23 its -PRON- PRP$ cord-028721-x6f26ahr 1581 24 diagnosis diagnosis NN cord-028721-x6f26ahr 1581 25 may may MD cord-028721-x6f26ahr 1581 26 be be VB cord-028721-x6f26ahr 1581 27 delayed delay VBN cord-028721-x6f26ahr 1581 28 until until IN cord-028721-x6f26ahr 1581 29 puberty puberty NN cord-028721-x6f26ahr 1581 30 . . . cord-028721-x6f26ahr 1582 1 Severe severe JJ cord-028721-x6f26ahr 1582 2 forms form NNS cord-028721-x6f26ahr 1582 3 of of IN cord-028721-x6f26ahr 1582 4 3BHSD 3bhsd CD cord-028721-x6f26ahr 1582 5 defi defi NNP cord-028721-x6f26ahr 1582 6 ciency ciency NNP cord-028721-x6f26ahr 1582 7 are be VBP cord-028721-x6f26ahr 1582 8 associated associate VBN cord-028721-x6f26ahr 1582 9 with with IN cord-028721-x6f26ahr 1582 10 defi defi NNP cord-028721-x6f26ahr 1582 11 cits cits NNP cord-028721-x6f26ahr 1582 12 in in IN cord-028721-x6f26ahr 1582 13 aldosterone aldosterone NN cord-028721-x6f26ahr 1582 14 , , , cord-028721-x6f26ahr 1582 15 cortisol cortisol NN cord-028721-x6f26ahr 1582 16 , , , cord-028721-x6f26ahr 1582 17 and and CC cord-028721-x6f26ahr 1582 18 estradiol estradiol NN cord-028721-x6f26ahr 1582 19 . . . cord-028721-x6f26ahr 1583 1 Symptoms symptom NNS cord-028721-x6f26ahr 1583 2 may may MD cord-028721-x6f26ahr 1583 3 vary vary VB cord-028721-x6f26ahr 1583 4 widely widely RB cord-028721-x6f26ahr 1583 5 , , , cord-028721-x6f26ahr 1583 6 as as IN cord-028721-x6f26ahr 1583 7 enzymatic enzymatic JJ cord-028721-x6f26ahr 1583 8 activity activity NN cord-028721-x6f26ahr 1583 9 in in IN cord-028721-x6f26ahr 1583 10 the the DT cord-028721-x6f26ahr 1583 11 adrenal adrenal JJ cord-028721-x6f26ahr 1583 12 gland gland NN cord-028721-x6f26ahr 1583 13 is be VBZ cord-028721-x6f26ahr 1583 14 not not RB cord-028721-x6f26ahr 1583 15 the the DT cord-028721-x6f26ahr 1583 16 same same JJ cord-028721-x6f26ahr 1583 17 as as IN cord-028721-x6f26ahr 1583 18 in in IN cord-028721-x6f26ahr 1583 19 the the DT cord-028721-x6f26ahr 1583 20 testis testis NN cord-028721-x6f26ahr 1583 21 . . . cord-028721-x6f26ahr 1584 1 Most Most JJS cord-028721-x6f26ahr 1584 2 patients patient NNS cord-028721-x6f26ahr 1584 3 show show VBP cord-028721-x6f26ahr 1584 4 salt salt NN cord-028721-x6f26ahr 1584 5 loss loss NN cord-028721-x6f26ahr 1584 6 and and CC cord-028721-x6f26ahr 1584 7 adrenal adrenal JJ cord-028721-x6f26ahr 1584 8 crisis crisis NN cord-028721-x6f26ahr 1584 9 ; ; : cord-028721-x6f26ahr 1584 10 they -PRON- PRP cord-028721-x6f26ahr 1584 11 have have VBP cord-028721-x6f26ahr 1584 12 incomplete incomplete JJ cord-028721-x6f26ahr 1584 13 masculinization masculinization NN cord-028721-x6f26ahr 1584 14 and and CC cord-028721-x6f26ahr 1584 15 may may MD cord-028721-x6f26ahr 1584 16 develop develop VB cord-028721-x6f26ahr 1584 17 spontaneous spontaneous JJ cord-028721-x6f26ahr 1584 18 puberty puberty NN cord-028721-x6f26ahr 1584 19 and and CC cord-028721-x6f26ahr 1584 20 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1584 21 . . . cord-028721-x6f26ahr 1585 1 706 706 CD cord-028721-x6f26ahr 1585 2 , , , cord-028721-x6f26ahr 1585 3 707 707 CD cord-028721-x6f26ahr 1585 4 , , , cord-028721-x6f26ahr 1585 5 713 713 CD cord-028721-x6f26ahr 1585 6 Patients patient NNS cord-028721-x6f26ahr 1585 7 with with IN cord-028721-x6f26ahr 1585 8 mild mild JJ cord-028721-x6f26ahr 1585 9 forms form NNS cord-028721-x6f26ahr 1585 10 have have VBP cord-028721-x6f26ahr 1585 11 normal normal JJ cord-028721-x6f26ahr 1585 12 genitalia genitalia NNS cord-028721-x6f26ahr 1585 13 and and CC cord-028721-x6f26ahr 1585 14 normal normal JJ cord-028721-x6f26ahr 1585 15 mineralocorticoid mineralocorticoid NN cord-028721-x6f26ahr 1585 16 levels level NNS cord-028721-x6f26ahr 1585 17 . . . cord-028721-x6f26ahr 1586 1 Some some DT cord-028721-x6f26ahr 1586 2 patients patient NNS cord-028721-x6f26ahr 1586 3 have have VBP cord-028721-x6f26ahr 1586 4 only only RB cord-028721-x6f26ahr 1586 5 hypospadias hypospadia NNS cord-028721-x6f26ahr 1586 6 714 714 CD cord-028721-x6f26ahr 1586 7 or or CC cord-028721-x6f26ahr 1586 8 micropenis micropenis NN cord-028721-x6f26ahr 1586 9 . . . cord-028721-x6f26ahr 1587 1 715 715 CD cord-028721-x6f26ahr 1588 1 The the DT cord-028721-x6f26ahr 1588 2 testes testis NNS cord-028721-x6f26ahr 1588 3 are be VBP cord-028721-x6f26ahr 1588 4 smaller small JJR cord-028721-x6f26ahr 1588 5 and and CC cord-028721-x6f26ahr 1588 6 softer soft JJR cord-028721-x6f26ahr 1588 7 than than IN cord-028721-x6f26ahr 1588 8 normal normal JJ cord-028721-x6f26ahr 1588 9 . . . cord-028721-x6f26ahr 1589 1 17α 17α CD cord-028721-x6f26ahr 1589 2 - - HYPH cord-028721-x6f26ahr 1589 3 Hydroxylase hydroxylase NN cord-028721-x6f26ahr 1589 4 defi defi NN cord-028721-x6f26ahr 1589 5 ciency ciency NN cord-028721-x6f26ahr 1590 1 The the DT cord-028721-x6f26ahr 1590 2 cause cause NN cord-028721-x6f26ahr 1590 3 of of IN cord-028721-x6f26ahr 1590 4 defi defi NNP cord-028721-x6f26ahr 1590 5 cits cits NNP cord-028721-x6f26ahr 1590 6 in in IN cord-028721-x6f26ahr 1590 7 the the DT cord-028721-x6f26ahr 1590 8 enzymes enzyme NNS cord-028721-x6f26ahr 1590 9 17α 17α CD cord-028721-x6f26ahr 1590 10 - - HYPH cord-028721-x6f26ahr 1590 11 hydroxylase hydroxylase NN cord-028721-x6f26ahr 1590 12 and and CC cord-028721-x6f26ahr 1590 13 17,20-lyase 17,20-lyase NNP cord-028721-x6f26ahr 1590 14 are be VBP cord-028721-x6f26ahr 1590 15 mutations mutation NNS cord-028721-x6f26ahr 1590 16 of of IN cord-028721-x6f26ahr 1590 17 the the DT cord-028721-x6f26ahr 1590 18 CYP17 CYP17 NNP cord-028721-x6f26ahr 1590 19 gene gene NN cord-028721-x6f26ahr 1590 20 that that WDT cord-028721-x6f26ahr 1590 21 encodes encode VBZ cord-028721-x6f26ahr 1590 22 cytochrome cytochrome NN cord-028721-x6f26ahr 1590 23 P450c17 p450c17 NN cord-028721-x6f26ahr 1590 24 . . . cord-028721-x6f26ahr 1591 1 716 716 CD cord-028721-x6f26ahr 1592 1 The the DT cord-028721-x6f26ahr 1592 2 CYP17 CYP17 NNP cord-028721-x6f26ahr 1592 3 gene gene NN cord-028721-x6f26ahr 1592 4 is be VBZ cord-028721-x6f26ahr 1592 5 located locate VBN cord-028721-x6f26ahr 1592 6 on on IN cord-028721-x6f26ahr 1592 7 chromosome chromosome NN cord-028721-x6f26ahr 1592 8 10q24-q25 10q24-q25 CD cord-028721-x6f26ahr 1592 9 , , , cord-028721-x6f26ahr 1592 10 717 717 CD cord-028721-x6f26ahr 1592 11 and and CC cord-028721-x6f26ahr 1592 12 50 50 CD cord-028721-x6f26ahr 1592 13 different different JJ cord-028721-x6f26ahr 1592 14 mutations mutation NNS cord-028721-x6f26ahr 1592 15 have have VBP cord-028721-x6f26ahr 1592 16 been be VBN cord-028721-x6f26ahr 1592 17 described describe VBN cord-028721-x6f26ahr 1592 18 . . . cord-028721-x6f26ahr 1593 1 718 718 CD cord-028721-x6f26ahr 1594 1 P450c17 P450c17 NNP cord-028721-x6f26ahr 1594 2 catalyzes catalyze VBZ cord-028721-x6f26ahr 1594 3 the the DT cord-028721-x6f26ahr 1594 4 17α 17α CD cord-028721-x6f26ahr 1594 5 - - HYPH cord-028721-x6f26ahr 1594 6 hydroxylation hydroxylation NN cord-028721-x6f26ahr 1594 7 of of IN cord-028721-x6f26ahr 1594 8 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1594 9 to to IN cord-028721-x6f26ahr 1594 10 17OHpregnenolone 17ohpregnenolone CD cord-028721-x6f26ahr 1594 11 and and CC cord-028721-x6f26ahr 1594 12 of of IN cord-028721-x6f26ahr 1594 13 progesterone progesterone NN cord-028721-x6f26ahr 1594 14 to to IN cord-028721-x6f26ahr 1594 15 17α 17α CD cord-028721-x6f26ahr 1594 16 - - : cord-028721-x6f26ahr 1594 17 OH oh NN cord-028721-x6f26ahr 1594 18 - - HYPH cord-028721-x6f26ahr 1594 19 progesterone progesterone NN cord-028721-x6f26ahr 1594 20 . . . cord-028721-x6f26ahr 1595 1 This this DT cord-028721-x6f26ahr 1595 2 enzyme enzyme NN cord-028721-x6f26ahr 1595 3 also also RB cord-028721-x6f26ahr 1595 4 catalyzes catalyze VBZ cord-028721-x6f26ahr 1595 5 17,20-lyase 17,20-lyase CD cord-028721-x6f26ahr 1595 6 activity activity NN cord-028721-x6f26ahr 1595 7 , , , cord-028721-x6f26ahr 1595 8 transforming transform VBG cord-028721-x6f26ahr 1595 9 17OH 17oh CD cord-028721-x6f26ahr 1595 10 - - HYPH cord-028721-x6f26ahr 1595 11 pregnenolone pregnenolone NN cord-028721-x6f26ahr 1595 12 to to IN cord-028721-x6f26ahr 1595 13 DHEA DHEA NNP cord-028721-x6f26ahr 1595 14 . . . cord-028721-x6f26ahr 1596 1 The the DT cord-028721-x6f26ahr 1596 2 classic classic JJ cord-028721-x6f26ahr 1596 3 form form NN cord-028721-x6f26ahr 1596 4 of of IN cord-028721-x6f26ahr 1596 5 17αhydroxylase 17αhydroxylase CD cord-028721-x6f26ahr 1596 6 defi defi NNP cord-028721-x6f26ahr 1596 7 cit cit NNP cord-028721-x6f26ahr 1596 8 is be VBZ cord-028721-x6f26ahr 1596 9 caused cause VBN cord-028721-x6f26ahr 1596 10 by by IN cord-028721-x6f26ahr 1596 11 severe severe JJ cord-028721-x6f26ahr 1596 12 defi defi NN cord-028721-x6f26ahr 1596 13 ciencies ciencie NNS cord-028721-x6f26ahr 1596 14 in in IN cord-028721-x6f26ahr 1596 15 CYP17 CYP17 NNP cord-028721-x6f26ahr 1596 16 ; ; : cord-028721-x6f26ahr 1596 17 less less JJR cord-028721-x6f26ahr 1596 18 severe severe JJ cord-028721-x6f26ahr 1596 19 defects defect NNS cord-028721-x6f26ahr 1596 20 give give VBP cord-028721-x6f26ahr 1596 21 rise rise NN cord-028721-x6f26ahr 1596 22 to to IN cord-028721-x6f26ahr 1596 23 the the DT cord-028721-x6f26ahr 1596 24 isolated isolate VBN cord-028721-x6f26ahr 1596 25 17,20-lyase 17,20-lyase NNP cord-028721-x6f26ahr 1596 26 defi defi NNP cord-028721-x6f26ahr 1596 27 cit cit NN cord-028721-x6f26ahr 1596 28 . . . cord-028721-x6f26ahr 1597 1 17α 17α CD cord-028721-x6f26ahr 1597 2 - - HYPH cord-028721-x6f26ahr 1597 3 Hydroxylase hydroxylase NN cord-028721-x6f26ahr 1597 4 defi defi NNP cord-028721-x6f26ahr 1597 5 cit cit NNP cord-028721-x6f26ahr 1597 6 impairs impair VBZ cord-028721-x6f26ahr 1597 7 the the DT cord-028721-x6f26ahr 1597 8 synthesis synthesis NN cord-028721-x6f26ahr 1597 9 of of IN cord-028721-x6f26ahr 1597 10 both both CC cord-028721-x6f26ahr 1597 11 cortisol cortisol NN cord-028721-x6f26ahr 1597 12 and and CC cord-028721-x6f26ahr 1597 13 testosterone testosterone NN cord-028721-x6f26ahr 1597 14 . . . cord-028721-x6f26ahr 1598 1 719 719 CD cord-028721-x6f26ahr 1598 2 Low low JJ cord-028721-x6f26ahr 1598 3 cortisol cortisol NN cord-028721-x6f26ahr 1598 4 levels level NNS cord-028721-x6f26ahr 1598 5 stimulate stimulate VBP cord-028721-x6f26ahr 1598 6 ACTH ACTH NNP cord-028721-x6f26ahr 1598 7 secretion secretion NN cord-028721-x6f26ahr 1598 8 , , , cord-028721-x6f26ahr 1598 9 causing cause VBG cord-028721-x6f26ahr 1598 10 hypersecretion hypersecretion NN cord-028721-x6f26ahr 1598 11 of of IN cord-028721-x6f26ahr 1598 12 aldosterone aldosterone NN cord-028721-x6f26ahr 1598 13 precursors precursor NNS cord-028721-x6f26ahr 1598 14 and and CC cord-028721-x6f26ahr 1598 15 the the DT cord-028721-x6f26ahr 1598 16 development development NN cord-028721-x6f26ahr 1598 17 of of IN cord-028721-x6f26ahr 1598 18 hypokalemic hypokalemic NNP cord-028721-x6f26ahr 1598 19 hypertension hypertension NN cord-028721-x6f26ahr 1598 20 and and CC cord-028721-x6f26ahr 1598 21 male male JJ cord-028721-x6f26ahr 1598 22 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1598 23 in in IN cord-028721-x6f26ahr 1598 24 males male NNS cord-028721-x6f26ahr 1598 25 . . . cord-028721-x6f26ahr 1599 1 720 720 CD cord-028721-x6f26ahr 1599 2 Patients patient NNS cord-028721-x6f26ahr 1599 3 usually usually RB cord-028721-x6f26ahr 1599 4 have have VBP cord-028721-x6f26ahr 1599 5 hypospadias hypospadia NNS cord-028721-x6f26ahr 1599 6 and and CC cord-028721-x6f26ahr 1599 7 develop develop VB cord-028721-x6f26ahr 1599 8 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1599 9 at at IN cord-028721-x6f26ahr 1599 10 puberty puberty NN cord-028721-x6f26ahr 1599 11 . . . cord-028721-x6f26ahr 1600 1 721 721 CD cord-028721-x6f26ahr 1600 2 _SP cord-028721-x6f26ahr 1601 1 The the DT cord-028721-x6f26ahr 1601 2 enzyme enzyme NN cord-028721-x6f26ahr 1601 3 17,20-desmolase 17,20-desmolase NNP cord-028721-x6f26ahr 1601 4 cleaves cleave VBZ cord-028721-x6f26ahr 1601 5 the the DT cord-028721-x6f26ahr 1601 6 side side NN cord-028721-x6f26ahr 1601 7 chain chain NN cord-028721-x6f26ahr 1601 8 of of IN cord-028721-x6f26ahr 1601 9 17-hydroxypregnenolone 17-hydroxypregnenolone CD cord-028721-x6f26ahr 1601 10 and and CC cord-028721-x6f26ahr 1601 11 17hydroxyprogesterone 17hydroxyprogesterone CD cord-028721-x6f26ahr 1601 12 to to TO cord-028721-x6f26ahr 1601 13 form form VB cord-028721-x6f26ahr 1601 14 dehydroepiandrosterone dehydroepiandrosterone NN cord-028721-x6f26ahr 1601 15 and and CC cord-028721-x6f26ahr 1601 16 androstenedione androstenedione NN cord-028721-x6f26ahr 1601 17 , , , cord-028721-x6f26ahr 1601 18 respectively respectively RB cord-028721-x6f26ahr 1601 19 . . . cord-028721-x6f26ahr 1602 1 Varying vary VBG cord-028721-x6f26ahr 1602 2 degrees degree NNS cord-028721-x6f26ahr 1602 3 of of IN cord-028721-x6f26ahr 1602 4 17,20desmolase 17,20desmolase CD cord-028721-x6f26ahr 1602 5 defi defi NNP cord-028721-x6f26ahr 1602 6 ciency ciency NNP cord-028721-x6f26ahr 1602 7 are be VBP cord-028721-x6f26ahr 1602 8 seen see VBN cord-028721-x6f26ahr 1602 9 , , , cord-028721-x6f26ahr 1602 10 resulting result VBG cord-028721-x6f26ahr 1602 11 in in IN cord-028721-x6f26ahr 1602 12 varied varied JJ cord-028721-x6f26ahr 1602 13 development development NN cord-028721-x6f26ahr 1602 14 of of IN cord-028721-x6f26ahr 1602 15 external external JJ cord-028721-x6f26ahr 1602 16 genitalia genitalia NNS cord-028721-x6f26ahr 1602 17 , , , cord-028721-x6f26ahr 1602 18 ranging range VBG cord-028721-x6f26ahr 1602 19 from from IN cord-028721-x6f26ahr 1602 20 female female JJ cord-028721-x6f26ahr 1602 21 phenotype phenotype NN cord-028721-x6f26ahr 1602 22 to to IN cord-028721-x6f26ahr 1602 23 virilization virilization NN cord-028721-x6f26ahr 1602 24 with with IN cord-028721-x6f26ahr 1602 25 microphallus microphallus NN cord-028721-x6f26ahr 1602 26 , , , cord-028721-x6f26ahr 1602 27 bifi bifi NN cord-028721-x6f26ahr 1602 28 d d NN cord-028721-x6f26ahr 1602 29 scrotum scrotum NN cord-028721-x6f26ahr 1602 30 , , , cord-028721-x6f26ahr 1602 31 and and CC cord-028721-x6f26ahr 1602 32 perineal perineal JJ cord-028721-x6f26ahr 1602 33 hypospadias hypospadia NNS cord-028721-x6f26ahr 1602 34 . . . cord-028721-x6f26ahr 1603 1 In in IN cord-028721-x6f26ahr 1603 2 childhood childhood NN cord-028721-x6f26ahr 1603 3 , , , cord-028721-x6f26ahr 1603 4 the the DT cord-028721-x6f26ahr 1603 5 testes testis NNS cord-028721-x6f26ahr 1603 6 contain contain VBP cord-028721-x6f26ahr 1603 7 reduced reduce VBN cord-028721-x6f26ahr 1603 8 numbers number NNS cord-028721-x6f26ahr 1603 9 of of IN cord-028721-x6f26ahr 1603 10 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1603 11 ( ( -LRB- cord-028721-x6f26ahr 1603 12 Figs Figs NNP cord-028721-x6f26ahr 1603 13 12 12 CD cord-028721-x6f26ahr 1603 14 - - SYM cord-028721-x6f26ahr 1603 15 72 72 CD cord-028721-x6f26ahr 1603 16 , , , cord-028721-x6f26ahr 1603 17 12 12 CD cord-028721-x6f26ahr 1603 18 - - SYM cord-028721-x6f26ahr 1603 19 73 73 CD cord-028721-x6f26ahr 1603 20 ) ) -RRB- cord-028721-x6f26ahr 1603 21 . . . cord-028721-x6f26ahr 1604 1 722 722 CD cord-028721-x6f26ahr 1604 2 , , , cord-028721-x6f26ahr 1604 3 723 723 CD cord-028721-x6f26ahr 1605 1 The the DT cord-028721-x6f26ahr 1605 2 cause cause NN cord-028721-x6f26ahr 1605 3 may may MD cord-028721-x6f26ahr 1605 4 be be VB cord-028721-x6f26ahr 1605 5 mutations mutation NNS cord-028721-x6f26ahr 1605 6 in in IN cord-028721-x6f26ahr 1605 7 one one CD cord-028721-x6f26ahr 1605 8 of of IN cord-028721-x6f26ahr 1605 9 the the DT cord-028721-x6f26ahr 1605 10 genetic genetic JJ cord-028721-x6f26ahr 1605 11 loci locus NNS cord-028721-x6f26ahr 1605 12 encoding encoding NN cord-028721-x6f26ahr 1606 1 P450c17 P450c17 NNP cord-028721-x6f26ahr 1606 2 , , , cord-028721-x6f26ahr 1606 3 fl fl NNP cord-028721-x6f26ahr 1606 4 avoprotein avoprotein NNP cord-028721-x6f26ahr 1606 5 OR OR NNP cord-028721-x6f26ahr 1606 6 or or CC cord-028721-x6f26ahr 1606 7 b5 b5 NNP cord-028721-x6f26ahr 1606 8 . . . cord-028721-x6f26ahr 1607 1 724 724 CD cord-028721-x6f26ahr 1607 2 17β 17β CD cord-028721-x6f26ahr 1608 1 -Hydroxysteroid -Hydroxysteroid NNP cord-028721-x6f26ahr 1608 2 dehydrogenase dehydrogenase NNP cord-028721-x6f26ahr 1608 3 defi defi NNP cord-028721-x6f26ahr 1608 4 ciency ciency NNP cord-028721-x6f26ahr 1609 1 This this DT cord-028721-x6f26ahr 1609 2 enzyme enzyme NN cord-028721-x6f26ahr 1609 3 transforms transform VBZ cord-028721-x6f26ahr 1609 4 androstenedione androstenedione NN cord-028721-x6f26ahr 1609 5 into into IN cord-028721-x6f26ahr 1609 6 testosterone testosterone NN cord-028721-x6f26ahr 1609 7 and and CC cord-028721-x6f26ahr 1609 8 also also RB cord-028721-x6f26ahr 1609 9 converts convert VBZ cord-028721-x6f26ahr 1609 10 estrone estrone NN cord-028721-x6f26ahr 1609 11 into into IN cord-028721-x6f26ahr 1609 12 estradiol estradiol NN cord-028721-x6f26ahr 1609 13 . . . cord-028721-x6f26ahr 1610 1 The the DT cord-028721-x6f26ahr 1610 2 enzymatic enzymatic JJ cord-028721-x6f26ahr 1610 3 defects defect NNS cord-028721-x6f26ahr 1610 4 are be VBP cord-028721-x6f26ahr 1610 5 sexlinked sexlinke VBN cord-028721-x6f26ahr 1610 6 . . . cord-028721-x6f26ahr 1611 1 Most Most JJS cord-028721-x6f26ahr 1611 2 patients patient NNS cord-028721-x6f26ahr 1611 3 have have VBP cord-028721-x6f26ahr 1611 4 female female JJ cord-028721-x6f26ahr 1611 5 phenotype phenotype NN cord-028721-x6f26ahr 1611 6 at at IN cord-028721-x6f26ahr 1611 7 birth birth NN cord-028721-x6f26ahr 1611 8 and and CC cord-028721-x6f26ahr 1611 9 are be VBP cord-028721-x6f26ahr 1611 10 raised raise VBN cord-028721-x6f26ahr 1611 11 as as IN cord-028721-x6f26ahr 1611 12 girls girl NNS cord-028721-x6f26ahr 1611 13 , , , cord-028721-x6f26ahr 1611 14 but but CC cord-028721-x6f26ahr 1611 15 at at IN cord-028721-x6f26ahr 1611 16 puberty puberty NN cord-028721-x6f26ahr 1611 17 undergo undergo VBP cord-028721-x6f26ahr 1611 18 virilization virilization NN cord-028721-x6f26ahr 1611 19 . . . cord-028721-x6f26ahr 1612 1 725 725 CD cord-028721-x6f26ahr 1612 2 One one CD cord-028721-x6f26ahr 1612 3 or or CC cord-028721-x6f26ahr 1612 4 both both DT cord-028721-x6f26ahr 1612 5 testes testis NNS cord-028721-x6f26ahr 1612 6 may may MD cord-028721-x6f26ahr 1612 7 be be VB cord-028721-x6f26ahr 1612 8 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1612 9 or or CC cord-028721-x6f26ahr 1612 10 are be VBP cord-028721-x6f26ahr 1612 11 located locate VBN cord-028721-x6f26ahr 1612 12 in in IN cord-028721-x6f26ahr 1612 13 the the DT cord-028721-x6f26ahr 1612 14 labia labium NNS cord-028721-x6f26ahr 1612 15 majora majora NNP cord-028721-x6f26ahr 1612 16 . . . cord-028721-x6f26ahr 1613 1 Normal normal JJ cord-028721-x6f26ahr 1613 2 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1613 3 has have VBZ cord-028721-x6f26ahr 1613 4 never never RB cord-028721-x6f26ahr 1613 5 been be VBN cord-028721-x6f26ahr 1613 6 observed observe VBN cord-028721-x6f26ahr 1613 7 . . . cord-028721-x6f26ahr 1614 1 The the DT cord-028721-x6f26ahr 1614 2 most most RBS cord-028721-x6f26ahr 1614 3 common common JJ cord-028721-x6f26ahr 1614 4 testicular testicular JJ cord-028721-x6f26ahr 1614 5 patterns pattern NNS cord-028721-x6f26ahr 1614 6 are be VBP cord-028721-x6f26ahr 1614 7 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1614 8 or or CC cord-028721-x6f26ahr 1614 9 absence absence NN cord-028721-x6f26ahr 1614 10 of of IN cord-028721-x6f26ahr 1614 11 germ germ NN cord-028721-x6f26ahr 1614 12 cells cell NNS cord-028721-x6f26ahr 1614 13 and and CC cord-028721-x6f26ahr 1614 14 Leydig Leydig NNP cord-028721-x6f26ahr 1614 15 cell cell NN cord-028721-x6f26ahr 1614 16 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1614 17 . . . cord-028721-x6f26ahr 1615 1 726 726 CD cord-028721-x6f26ahr 1616 1 The the DT cord-028721-x6f26ahr 1616 2 germ germ NN cord-028721-x6f26ahr 1616 3 cell cell NN cord-028721-x6f26ahr 1616 4 injury injury NN cord-028721-x6f26ahr 1616 5 was be VBD cord-028721-x6f26ahr 1616 6 initially initially RB cord-028721-x6f26ahr 1616 7 attributed attribute VBN cord-028721-x6f26ahr 1616 8 to to IN cord-028721-x6f26ahr 1616 9 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1616 10 , , , cord-028721-x6f26ahr 1616 11 but but CC cord-028721-x6f26ahr 1616 12 it -PRON- PRP cord-028721-x6f26ahr 1616 13 is be VBZ cord-028721-x6f26ahr 1616 14 now now RB cord-028721-x6f26ahr 1616 15 thought think VBN cord-028721-x6f26ahr 1616 16 to to TO cord-028721-x6f26ahr 1616 17 be be VB cord-028721-x6f26ahr 1616 18 a a DT cord-028721-x6f26ahr 1616 19 primary primary JJ cord-028721-x6f26ahr 1616 20 testicular testicular JJ cord-028721-x6f26ahr 1616 21 lesion lesion NN cord-028721-x6f26ahr 1616 22 because because IN cord-028721-x6f26ahr 1616 23 even even RB cord-028721-x6f26ahr 1616 24 very very RB cord-028721-x6f26ahr 1616 25 young young JJ cord-028721-x6f26ahr 1616 26 patients patient NNS cord-028721-x6f26ahr 1616 27 lack lack VBP cord-028721-x6f26ahr 1616 28 germ germ NN cord-028721-x6f26ahr 1616 29 cells cell NNS cord-028721-x6f26ahr 1616 30 . . . cord-028721-x6f26ahr 1617 1 727 727 CD cord-028721-x6f26ahr 1618 1 This this DT cord-028721-x6f26ahr 1618 2 defi defi FW cord-028721-x6f26ahr 1618 3 cit cit NNP cord-028721-x6f26ahr 1618 4 is be VBZ cord-028721-x6f26ahr 1618 5 due due JJ cord-028721-x6f26ahr 1618 6 to to IN cord-028721-x6f26ahr 1618 7 mutations mutation NNS cord-028721-x6f26ahr 1618 8 in in IN cord-028721-x6f26ahr 1618 9 the the DT cord-028721-x6f26ahr 1618 10 HSD17B3 HSD17B3 NNP cord-028721-x6f26ahr 1618 11 gene gene NN cord-028721-x6f26ahr 1618 12 located locate VBN cord-028721-x6f26ahr 1618 13 on on IN cord-028721-x6f26ahr 1618 14 9q22 9q22 CD cord-028721-x6f26ahr 1618 15 . . . cord-028721-x6f26ahr 1619 1 728 728 CD cord-028721-x6f26ahr 1619 2 , , , cord-028721-x6f26ahr 1619 3 729 729 CD cord-028721-x6f26ahr 1619 4 Leydig leydig NN cord-028721-x6f26ahr 1619 5 cell cell NN cord-028721-x6f26ahr 1619 6 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1620 1 This this DT cord-028721-x6f26ahr 1620 2 variant variant NN cord-028721-x6f26ahr 1620 3 of of IN cord-028721-x6f26ahr 1620 4 male male JJ cord-028721-x6f26ahr 1620 5 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1620 6 is be VBZ cord-028721-x6f26ahr 1620 7 defi defi NNP cord-028721-x6f26ahr 1620 8 ned ned NNP cord-028721-x6f26ahr 1620 9 by by IN cord-028721-x6f26ahr 1620 10 insuffi insuffi NNP cord-028721-x6f26ahr 1620 11 cient cient NNP cord-028721-x6f26ahr 1620 12 testosterone testosterone NN cord-028721-x6f26ahr 1620 13 secretion secretion NN cord-028721-x6f26ahr 1620 14 422 422 CD cord-028721-x6f26ahr 1620 15 and and CC cord-028721-x6f26ahr 1620 16 the the DT cord-028721-x6f26ahr 1620 17 following follow VBG cord-028721-x6f26ahr 1620 18 characteristics characteristic NNS cord-028721-x6f26ahr 1620 19 : : : cord-028721-x6f26ahr 1620 20 predominance predominance NN cord-028721-x6f26ahr 1620 21 of of IN cord-028721-x6f26ahr 1620 22 female female JJ cord-028721-x6f26ahr 1620 23 external external JJ cord-028721-x6f26ahr 1620 24 genitalia genitalia NNS cord-028721-x6f26ahr 1620 25 ; ; : cord-028721-x6f26ahr 1620 26 absence absence NN cord-028721-x6f26ahr 1620 27 of of IN cord-028721-x6f26ahr 1620 28 male male JJ cord-028721-x6f26ahr 1620 29 secondary secondary JJ cord-028721-x6f26ahr 1620 30 sex sex NN cord-028721-x6f26ahr 1620 31 characteristics characteristic NNS cord-028721-x6f26ahr 1620 32 at at IN cord-028721-x6f26ahr 1620 33 puberty puberty NN cord-028721-x6f26ahr 1620 34 ; ; . cord-028721-x6f26ahr 1621 1 absence absence NN cord-028721-x6f26ahr 1621 2 of of IN cord-028721-x6f26ahr 1621 3 uterus uterus NN cord-028721-x6f26ahr 1621 4 and and CC cord-028721-x6f26ahr 1621 5 fallopian fallopian JJ cord-028721-x6f26ahr 1621 6 tubes tube NNS cord-028721-x6f26ahr 1621 7 and and CC cord-028721-x6f26ahr 1621 8 the the DT cord-028721-x6f26ahr 1621 9 presence presence NN cord-028721-x6f26ahr 1621 10 of of IN cord-028721-x6f26ahr 1621 11 epididymis epididymis NN cord-028721-x6f26ahr 1621 12 and and CC cord-028721-x6f26ahr 1621 13 vas vas NNP cord-028721-x6f26ahr 1621 14 deferens deferens NNP cord-028721-x6f26ahr 1622 1 ; ; : cord-028721-x6f26ahr 1622 2 46XY 46xy CD cord-028721-x6f26ahr 1622 3 karyotype karyotype NN cord-028721-x6f26ahr 1622 4 ; ; : cord-028721-x6f26ahr 1622 5 lack lack NN cord-028721-x6f26ahr 1622 6 of of IN cord-028721-x6f26ahr 1622 7 response response NN cord-028721-x6f26ahr 1622 8 to to IN cord-028721-x6f26ahr 1622 9 human human JJ cord-028721-x6f26ahr 1622 10 chorionic chorionic JJ cord-028721-x6f26ahr 1622 11 gonadotropin gonadotropin NN cord-028721-x6f26ahr 1622 12 stimulation stimulation NN cord-028721-x6f26ahr 1622 13 ; ; : cord-028721-x6f26ahr 1622 14 absence absence NN cord-028721-x6f26ahr 1622 15 of of IN cord-028721-x6f26ahr 1622 16 an an DT cord-028721-x6f26ahr 1622 17 enzymatic enzymatic JJ cord-028721-x6f26ahr 1622 18 defect defect NN cord-028721-x6f26ahr 1622 19 in in IN cord-028721-x6f26ahr 1622 20 testosterone testosterone NN cord-028721-x6f26ahr 1622 21 synthesis synthesis NN cord-028721-x6f26ahr 1622 22 ; ; , cord-028721-x6f26ahr 1622 23 and and CC cord-028721-x6f26ahr 1622 24 small small JJ cord-028721-x6f26ahr 1622 25 undescended undescended JJ cord-028721-x6f26ahr 1622 26 testes testis NNS cord-028721-x6f26ahr 1622 27 that that WDT cord-028721-x6f26ahr 1622 28 are be VBP cord-028721-x6f26ahr 1622 29 gray gray JJ cord-028721-x6f26ahr 1622 30 and and CC cord-028721-x6f26ahr 1622 31 mucous mucous JJ cord-028721-x6f26ahr 1622 32 on on IN cord-028721-x6f26ahr 1622 33 section section NN cord-028721-x6f26ahr 1622 34 . . . cord-028721-x6f26ahr 1623 1 [ [ -LRB- cord-028721-x6f26ahr 1623 2 730 730 CD cord-028721-x6f26ahr 1623 3 ] ] -RRB- cord-028721-x6f26ahr 1623 4 [ [ -LRB- cord-028721-x6f26ahr 1623 5 731 731 CD cord-028721-x6f26ahr 1623 6 ] ] -RRB- cord-028721-x6f26ahr 1623 7 [ [ -LRB- cord-028721-x6f26ahr 1623 8 732 732 CD cord-028721-x6f26ahr 1623 9 ] ] -RRB- cord-028721-x6f26ahr 1624 1 [ [ -LRB- cord-028721-x6f26ahr 1624 2 733 733 CD cord-028721-x6f26ahr 1624 3 ] ] -RRB- cord-028721-x6f26ahr 1625 1 Age age NN cord-028721-x6f26ahr 1625 2 at at IN cord-028721-x6f26ahr 1625 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1625 4 varies vary VBZ cord-028721-x6f26ahr 1625 5 from from IN cord-028721-x6f26ahr 1625 6 4 4 CD cord-028721-x6f26ahr 1625 7 months month NNS cord-028721-x6f26ahr 1625 8 to to IN cord-028721-x6f26ahr 1625 9 35 35 CD cord-028721-x6f26ahr 1625 10 years year NNS cord-028721-x6f26ahr 1625 11 . . . cord-028721-x6f26ahr 1626 1 The the DT cord-028721-x6f26ahr 1626 2 syndrome syndrome NN cord-028721-x6f26ahr 1626 3 is be VBZ cord-028721-x6f26ahr 1626 4 sporadic sporadic JJ cord-028721-x6f26ahr 1626 5 and and CC cord-028721-x6f26ahr 1626 6 familial familial JJ cord-028721-x6f26ahr 1626 7 . . . cord-028721-x6f26ahr 1627 1 734 734 CD cord-028721-x6f26ahr 1627 2 , , , cord-028721-x6f26ahr 1627 3 735 735 CD cord-028721-x6f26ahr 1628 1 The the DT cord-028721-x6f26ahr 1628 2 best well RBS cord-028721-x6f26ahr 1628 3 - - HYPH cord-028721-x6f26ahr 1628 4 known know VBN cord-028721-x6f26ahr 1628 5 cause cause NN cord-028721-x6f26ahr 1628 6 of of IN cord-028721-x6f26ahr 1628 7 Leydig Leydig NNP cord-028721-x6f26ahr 1628 8 cell cell NN cord-028721-x6f26ahr 1628 9 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1628 10 is be VBZ cord-028721-x6f26ahr 1628 11 inactivating inactivate VBG cord-028721-x6f26ahr 1628 12 mutation mutation NN cord-028721-x6f26ahr 1628 13 of of IN cord-028721-x6f26ahr 1628 14 the the DT cord-028721-x6f26ahr 1628 15 LH LH NNP cord-028721-x6f26ahr 1628 16 receptor receptor NN cord-028721-x6f26ahr 1628 17 in in IN cord-028721-x6f26ahr 1628 18 these these DT cord-028721-x6f26ahr 1628 19 cells cell NNS cord-028721-x6f26ahr 1628 20 . . . cord-028721-x6f26ahr 1629 1 [ [ -LRB- cord-028721-x6f26ahr 1629 2 736 736 CD cord-028721-x6f26ahr 1629 3 ] ] -RRB- cord-028721-x6f26ahr 1629 4 [ [ -LRB- cord-028721-x6f26ahr 1629 5 737 737 CD cord-028721-x6f26ahr 1629 6 ] ] -RRB- cord-028721-x6f26ahr 1629 7 [ [ -LRB- cord-028721-x6f26ahr 1629 8 738 738 CD cord-028721-x6f26ahr 1629 9 ] ] -RRB- cord-028721-x6f26ahr 1630 1 During during IN cord-028721-x6f26ahr 1630 2 fetal fetal JJ cord-028721-x6f26ahr 1630 3 life life NN cord-028721-x6f26ahr 1630 4 , , , cord-028721-x6f26ahr 1630 5 there there EX cord-028721-x6f26ahr 1630 6 is be VBZ cord-028721-x6f26ahr 1630 7 an an DT cord-028721-x6f26ahr 1630 8 inadequate inadequate JJ cord-028721-x6f26ahr 1630 9 response response NN cord-028721-x6f26ahr 1630 10 to to IN cord-028721-x6f26ahr 1630 11 placental placental JJ cord-028721-x6f26ahr 1630 12 hCG hcg NN cord-028721-x6f26ahr 1630 13 initially initially RB cord-028721-x6f26ahr 1630 14 and and CC cord-028721-x6f26ahr 1630 15 to to IN cord-028721-x6f26ahr 1630 16 pituitary pituitary NN cord-028721-x6f26ahr 1630 17 LH LH NNP cord-028721-x6f26ahr 1630 18 subsequently subsequently RB cord-028721-x6f26ahr 1630 19 . . . cord-028721-x6f26ahr 1631 1 Phenotypes phenotype NNS cord-028721-x6f26ahr 1631 2 vary vary VBP cord-028721-x6f26ahr 1631 3 widely widely RB cord-028721-x6f26ahr 1631 4 according accord VBG cord-028721-x6f26ahr 1631 5 to to IN cord-028721-x6f26ahr 1631 6 the the DT cord-028721-x6f26ahr 1631 7 presence presence NN cord-028721-x6f26ahr 1631 8 of of IN cord-028721-x6f26ahr 1631 9 complete complete JJ cord-028721-x6f26ahr 1631 10 or or CC cord-028721-x6f26ahr 1631 11 partial partial JJ cord-028721-x6f26ahr 1631 12 loss loss NN cord-028721-x6f26ahr 1631 13 of of IN cord-028721-x6f26ahr 1631 14 receptor receptor NN cord-028721-x6f26ahr 1631 15 function function NN cord-028721-x6f26ahr 1631 16 . . . cord-028721-x6f26ahr 1632 1 These these DT cord-028721-x6f26ahr 1632 2 changes change NNS cord-028721-x6f26ahr 1632 3 range range VBP cord-028721-x6f26ahr 1632 4 from from IN cord-028721-x6f26ahr 1632 5 male male JJ cord-028721-x6f26ahr 1632 6 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1632 7 with with IN cord-028721-x6f26ahr 1632 8 female female JJ cord-028721-x6f26ahr 1632 9 external external JJ cord-028721-x6f26ahr 1632 10 genitalia genitalia NNS cord-028721-x6f26ahr 1632 11 ( ( -LRB- cord-028721-x6f26ahr 1632 12 type type NN cord-028721-x6f26ahr 1632 13 I -PRON- PRP cord-028721-x6f26ahr 1632 14 of of IN cord-028721-x6f26ahr 1632 15 Leydig Leydig NNP cord-028721-x6f26ahr 1632 16 cell cell NN cord-028721-x6f26ahr 1632 17 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1632 18 ) ) -RRB- cord-028721-x6f26ahr 1632 19 to to IN cord-028721-x6f26ahr 1632 20 male male JJ cord-028721-x6f26ahr 1632 21 phenotype phenotype NN cord-028721-x6f26ahr 1632 22 with with IN cord-028721-x6f26ahr 1632 23 micropenis micropeni NNS cord-028721-x6f26ahr 1632 24 , , , cord-028721-x6f26ahr 1632 25 hypospadias hypospadia NNS cord-028721-x6f26ahr 1632 26 , , , cord-028721-x6f26ahr 1632 27 pubertal pubertal JJ cord-028721-x6f26ahr 1632 28 delay delay NN cord-028721-x6f26ahr 1632 29 , , , cord-028721-x6f26ahr 1632 30 and and CC cord-028721-x6f26ahr 1632 31 primary primary JJ cord-028721-x6f26ahr 1632 32 hypogonadism hypogonadism NN cord-028721-x6f26ahr 1632 33 ( ( -LRB- cord-028721-x6f26ahr 1632 34 type type NN cord-028721-x6f26ahr 1632 35 II II NNP cord-028721-x6f26ahr 1632 36 of of IN cord-028721-x6f26ahr 1632 37 Leydig Leydig NNP cord-028721-x6f26ahr 1632 38 cell cell NN cord-028721-x6f26ahr 1632 39 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1632 40 ) ) -RRB- cord-028721-x6f26ahr 1632 41 . . . cord-028721-x6f26ahr 1633 1 In in IN cord-028721-x6f26ahr 1633 2 type type NN cord-028721-x6f26ahr 1633 3 I -PRON- PRP cord-028721-x6f26ahr 1633 4 hypoplasia hypoplasia VBP cord-028721-x6f26ahr 1633 5 , , , cord-028721-x6f26ahr 1633 6 the the DT cord-028721-x6f26ahr 1633 7 testes testis NNS cord-028721-x6f26ahr 1633 8 contain contain VBP cord-028721-x6f26ahr 1633 9 small small JJ cord-028721-x6f26ahr 1633 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 1633 11 tubules tubule NNS cord-028721-x6f26ahr 1633 12 with with IN cord-028721-x6f26ahr 1633 13 Sertoli Sertoli NNP cord-028721-x6f26ahr 1633 14 cells cell NNS cord-028721-x6f26ahr 1633 15 , , , cord-028721-x6f26ahr 1633 16 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1633 17 , , , cord-028721-x6f26ahr 1633 18 and and CC cord-028721-x6f26ahr 1633 19 thickened thickened JJ cord-028721-x6f26ahr 1633 20 basement basement NN cord-028721-x6f26ahr 1633 21 membranes membrane NNS cord-028721-x6f26ahr 1633 22 . . . cord-028721-x6f26ahr 1634 1 Leydig leydig NN cord-028721-x6f26ahr 1634 2 cells cell NNS cord-028721-x6f26ahr 1634 3 are be VBP cord-028721-x6f26ahr 1634 4 rare rare JJ cord-028721-x6f26ahr 1634 5 or or CC cord-028721-x6f26ahr 1634 6 absent absent JJ cord-028721-x6f26ahr 1634 7 , , , cord-028721-x6f26ahr 1634 8 in in IN cord-028721-x6f26ahr 1634 9 contrast contrast NN cord-028721-x6f26ahr 1634 10 to to IN cord-028721-x6f26ahr 1634 11 Leydig leydig NN cord-028721-x6f26ahr 1634 12 cell cell NN cord-028721-x6f26ahr 1634 13 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1634 14 seen see VBN cord-028721-x6f26ahr 1634 15 in in IN cord-028721-x6f26ahr 1634 16 other other JJ cord-028721-x6f26ahr 1634 17 types type NNS cord-028721-x6f26ahr 1634 18 of of IN cord-028721-x6f26ahr 1634 19 male male JJ cord-028721-x6f26ahr 1634 20 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1634 21 , , , cord-028721-x6f26ahr 1634 22 such such JJ cord-028721-x6f26ahr 1634 23 as as IN cord-028721-x6f26ahr 1634 24 those those DT cord-028721-x6f26ahr 1634 25 arising arise VBG cord-028721-x6f26ahr 1634 26 from from IN cord-028721-x6f26ahr 1634 27 defects defect NNS cord-028721-x6f26ahr 1634 28 in in IN cord-028721-x6f26ahr 1634 29 androgen androgen NN cord-028721-x6f26ahr 1634 30 synthesis synthesis NN cord-028721-x6f26ahr 1634 31 or or CC cord-028721-x6f26ahr 1634 32 androgen androgen NN cord-028721-x6f26ahr 1634 33 action action NN cord-028721-x6f26ahr 1634 34 on on IN cord-028721-x6f26ahr 1634 35 peripheral peripheral JJ cord-028721-x6f26ahr 1634 36 tissues tissue NNS cord-028721-x6f26ahr 1634 37 . . . cord-028721-x6f26ahr 1635 1 739 739 CD cord-028721-x6f26ahr 1635 2 , , , cord-028721-x6f26ahr 1635 3 740 740 CD cord-028721-x6f26ahr 1635 4 Leydig Leydig NNP cord-028721-x6f26ahr 1635 5 cell cell NN cord-028721-x6f26ahr 1635 6 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1635 7 accounts account VBZ cord-028721-x6f26ahr 1635 8 for for IN cord-028721-x6f26ahr 1635 9 low low JJ cord-028721-x6f26ahr 1635 10 serum serum NN cord-028721-x6f26ahr 1635 11 testosterone testosterone NN cord-028721-x6f26ahr 1635 12 levels level NNS cord-028721-x6f26ahr 1635 13 , , , cord-028721-x6f26ahr 1635 14 lack lack NN cord-028721-x6f26ahr 1635 15 of of IN cord-028721-x6f26ahr 1635 16 virilization virilization NN cord-028721-x6f26ahr 1635 17 , , , cord-028721-x6f26ahr 1635 18 and and CC cord-028721-x6f26ahr 1635 19 lack lack NN cord-028721-x6f26ahr 1635 20 of of IN cord-028721-x6f26ahr 1635 21 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1635 22 . . . cord-028721-x6f26ahr 1636 1 The the DT cord-028721-x6f26ahr 1636 2 absence absence NN cord-028721-x6f26ahr 1636 3 of of IN cord-028721-x6f26ahr 1636 4 müllerian müllerian JJ cord-028721-x6f26ahr 1636 5 derivatives derivative NNS cord-028721-x6f26ahr 1636 6 suggests suggest VBZ cord-028721-x6f26ahr 1636 7 a a DT cord-028721-x6f26ahr 1636 8 normal normal JJ cord-028721-x6f26ahr 1636 9 function function NN cord-028721-x6f26ahr 1636 10 of of IN cord-028721-x6f26ahr 1636 11 Sertoli Sertoli NNP cord-028721-x6f26ahr 1636 12 cells cell NNS cord-028721-x6f26ahr 1636 13 , , , cord-028721-x6f26ahr 1636 14 which which WDT cord-028721-x6f26ahr 1636 15 synthesize synthesize VBP cord-028721-x6f26ahr 1636 16 müllerian müllerian JJ cord-028721-x6f26ahr 1636 17 inhibiting inhibit VBG cord-028721-x6f26ahr 1636 18 factor factor NN cord-028721-x6f26ahr 1636 19 . . . cord-028721-x6f26ahr 1637 1 In in IN cord-028721-x6f26ahr 1637 2 type type NN cord-028721-x6f26ahr 1637 3 II ii CD cord-028721-x6f26ahr 1637 4 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1637 5 , , , cord-028721-x6f26ahr 1637 6 adult adult NN cord-028721-x6f26ahr 1637 7 testes testis NNS cord-028721-x6f26ahr 1637 8 show show VBP cord-028721-x6f26ahr 1637 9 maturation maturation NN cord-028721-x6f26ahr 1637 10 arrest arrest NN cord-028721-x6f26ahr 1637 11 of of IN cord-028721-x6f26ahr 1637 12 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1637 13 and and CC cord-028721-x6f26ahr 1637 14 a a DT cord-028721-x6f26ahr 1637 15 few few JJ cord-028721-x6f26ahr 1637 16 incompletely incompletely RB cord-028721-x6f26ahr 1637 17 differentiated differentiate VBN cord-028721-x6f26ahr 1637 18 Leydig Leydig NNP cord-028721-x6f26ahr 1637 19 cells cell NNS cord-028721-x6f26ahr 1637 20 . . . cord-028721-x6f26ahr 1638 1 741 741 CD cord-028721-x6f26ahr 1638 2 , , , cord-028721-x6f26ahr 1638 3 742 742 CD cord-028721-x6f26ahr 1638 4 _SP cord-028721-x6f26ahr 1638 5 Resistance Resistance NNP cord-028721-x6f26ahr 1638 6 to to IN cord-028721-x6f26ahr 1638 7 androgen androgen NN cord-028721-x6f26ahr 1638 8 stimulation stimulation NN cord-028721-x6f26ahr 1638 9 is be VBZ cord-028721-x6f26ahr 1638 10 the the DT cord-028721-x6f26ahr 1638 11 cause cause NN cord-028721-x6f26ahr 1638 12 of of IN cord-028721-x6f26ahr 1638 13 several several JJ cord-028721-x6f26ahr 1638 14 syndromes syndrome NNS cord-028721-x6f26ahr 1638 15 with with IN cord-028721-x6f26ahr 1638 16 phenotypes phenotype NNS cord-028721-x6f26ahr 1638 17 varying vary VBG cord-028721-x6f26ahr 1638 18 from from IN cord-028721-x6f26ahr 1638 19 complete complete JJ cord-028721-x6f26ahr 1638 20 testicular testicular JJ cord-028721-x6f26ahr 1638 21 feminization feminization NN cord-028721-x6f26ahr 1638 22 743 743 CD cord-028721-x6f26ahr 1638 23 to to IN cord-028721-x6f26ahr 1638 24 normal normal JJ cord-028721-x6f26ahr 1638 25 male male NN cord-028721-x6f26ahr 1638 26 . . . cord-028721-x6f26ahr 1639 1 744 744 CD cord-028721-x6f26ahr 1639 2 , , , cord-028721-x6f26ahr 1639 3 745 745 CD cord-028721-x6f26ahr 1640 1 These these DT cord-028721-x6f26ahr 1640 2 syndromes syndrome NNS cord-028721-x6f26ahr 1640 3 are be VBP cord-028721-x6f26ahr 1640 4 caused cause VBN cord-028721-x6f26ahr 1640 5 by by IN cord-028721-x6f26ahr 1640 6 partial partial JJ cord-028721-x6f26ahr 1640 7 or or CC cord-028721-x6f26ahr 1640 8 complete complete JJ cord-028721-x6f26ahr 1640 9 lack lack NN cord-028721-x6f26ahr 1640 10 of of IN cord-028721-x6f26ahr 1640 11 response response NN cord-028721-x6f26ahr 1640 12 of of IN cord-028721-x6f26ahr 1640 13 the the DT cord-028721-x6f26ahr 1640 14 target target NN cord-028721-x6f26ahr 1640 15 organs organ NNS cord-028721-x6f26ahr 1640 16 to to TO cord-028721-x6f26ahr 1640 17 androgens androgens VB cord-028721-x6f26ahr 1640 18 746 746 CD cord-028721-x6f26ahr 1640 19 due due IN cord-028721-x6f26ahr 1640 20 to to IN cord-028721-x6f26ahr 1640 21 the the DT cord-028721-x6f26ahr 1640 22 absence absence NN cord-028721-x6f26ahr 1640 23 , , , cord-028721-x6f26ahr 1640 24 diminution diminution NN cord-028721-x6f26ahr 1640 25 , , , cord-028721-x6f26ahr 1640 26 or or CC cord-028721-x6f26ahr 1640 27 impairment impairment NN cord-028721-x6f26ahr 1640 28 of of IN cord-028721-x6f26ahr 1640 29 androgen androgen NN cord-028721-x6f26ahr 1640 30 receptors receptor NNS cord-028721-x6f26ahr 1640 31 or or CC cord-028721-x6f26ahr 1640 32 postreceptor postreceptor NN cord-028721-x6f26ahr 1640 33 anomaly anomaly NN cord-028721-x6f26ahr 1640 34 . . . cord-028721-x6f26ahr 1641 1 740 740 CD cord-028721-x6f26ahr 1642 1 The the DT cord-028721-x6f26ahr 1642 2 gene gene NN cord-028721-x6f26ahr 1642 3 for for IN cord-028721-x6f26ahr 1642 4 the the DT cord-028721-x6f26ahr 1642 5 androgen androgen NN cord-028721-x6f26ahr 1642 6 receptor receptor NN cord-028721-x6f26ahr 1642 7 is be VBZ cord-028721-x6f26ahr 1642 8 located locate VBN cord-028721-x6f26ahr 1642 9 on on IN cord-028721-x6f26ahr 1642 10 the the DT cord-028721-x6f26ahr 1642 11 X x NN cord-028721-x6f26ahr 1642 12 chromosome chromosome NN cord-028721-x6f26ahr 1642 13 ( ( -LRB- cord-028721-x6f26ahr 1642 14 Xq11-q12 Xq11-q12 NNP cord-028721-x6f26ahr 1642 15 ) ) -RRB- cord-028721-x6f26ahr 1642 16 , , , cord-028721-x6f26ahr 1642 17 and and CC cord-028721-x6f26ahr 1642 18 X X NNS cord-028721-x6f26ahr 1642 19 - - HYPH cord-028721-x6f26ahr 1642 20 linked link VBN cord-028721-x6f26ahr 1642 21 transmission transmission NN cord-028721-x6f26ahr 1642 22 occurs occur VBZ cord-028721-x6f26ahr 1642 23 in in IN cord-028721-x6f26ahr 1642 24 two two CD cord-028721-x6f26ahr 1642 25 - - HYPH cord-028721-x6f26ahr 1642 26 thirds third NNS cord-028721-x6f26ahr 1642 27 of of IN cord-028721-x6f26ahr 1642 28 cases case NNS cord-028721-x6f26ahr 1642 29 . . . cord-028721-x6f26ahr 1643 1 The the DT cord-028721-x6f26ahr 1643 2 karyotype karyotype NN cord-028721-x6f26ahr 1643 3 is be VBZ cord-028721-x6f26ahr 1643 4 usually usually RB cord-028721-x6f26ahr 1643 5 46XY 46xy CD cord-028721-x6f26ahr 1643 6 , , , cord-028721-x6f26ahr 1643 7 but but CC cord-028721-x6f26ahr 1643 8 47XXY 47xxy CD cord-028721-x6f26ahr 1643 9 and and CC cord-028721-x6f26ahr 1643 10 several several JJ cord-028721-x6f26ahr 1643 11 mosaicisms mosaicism NNS cord-028721-x6f26ahr 1643 12 have have VBP cord-028721-x6f26ahr 1643 13 been be VBN cord-028721-x6f26ahr 1643 14 observed observe VBN cord-028721-x6f26ahr 1643 15 . . . cord-028721-x6f26ahr 1644 1 747 747 CD cord-028721-x6f26ahr 1645 1 These these DT cord-028721-x6f26ahr 1645 2 syndromes syndrome NNS cord-028721-x6f26ahr 1645 3 affect affect VBP cord-028721-x6f26ahr 1645 4 1 1 CD cord-028721-x6f26ahr 1645 5 : : SYM cord-028721-x6f26ahr 1645 6 20 20 CD cord-028721-x6f26ahr 1645 7 000 000 CD cord-028721-x6f26ahr 1645 8 - - HYPH cord-028721-x6f26ahr 1645 9 1 1 CD cord-028721-x6f26ahr 1645 10 : : SYM cord-028721-x6f26ahr 1645 11 40 40 CD cord-028721-x6f26ahr 1645 12 000 000 CD cord-028721-x6f26ahr 1645 13 newborns newborn NNS cord-028721-x6f26ahr 1645 14 . . . cord-028721-x6f26ahr 1646 1 The the DT cord-028721-x6f26ahr 1646 2 diverse diverse JJ cord-028721-x6f26ahr 1646 3 phenotypes phenotype NNS cord-028721-x6f26ahr 1646 4 associated associate VBN cord-028721-x6f26ahr 1646 5 with with IN cord-028721-x6f26ahr 1646 6 androgen androgen NN cord-028721-x6f26ahr 1646 7 insensitivity insensitivity NN cord-028721-x6f26ahr 1646 8 may may MD cord-028721-x6f26ahr 1646 9 be be VB cord-028721-x6f26ahr 1646 10 classifi classifi NNP cord-028721-x6f26ahr 1646 11 ed ed NNP cord-028721-x6f26ahr 1646 12 as as IN cord-028721-x6f26ahr 1646 13 : : : cord-028721-x6f26ahr 1646 14 complete complete VB cord-028721-x6f26ahr 1646 15 androgen androgen NN cord-028721-x6f26ahr 1646 16 insensitivity insensitivity NN cord-028721-x6f26ahr 1646 17 syndrome syndrome NN cord-028721-x6f26ahr 1646 18 ( ( -LRB- cord-028721-x6f26ahr 1646 19 CAIS CAIS NNP cord-028721-x6f26ahr 1646 20 ) ) -RRB- cord-028721-x6f26ahr 1646 21 or or CC cord-028721-x6f26ahr 1646 22 testicular testicular JJ cord-028721-x6f26ahr 1646 23 feminization feminization NN cord-028721-x6f26ahr 1646 24 syndrome syndrome NN cord-028721-x6f26ahr 1646 25 ; ; , cord-028721-x6f26ahr 1646 26 partial partial JJ cord-028721-x6f26ahr 1646 27 androgen androgen NN cord-028721-x6f26ahr 1646 28 insensitivity insensitivity NN cord-028721-x6f26ahr 1646 29 syndrome syndrome NN cord-028721-x6f26ahr 1646 30 ( ( -LRB- cord-028721-x6f26ahr 1646 31 PAIS PAIS NNP cord-028721-x6f26ahr 1646 32 ) ) -RRB- cord-028721-x6f26ahr 1646 33 or or CC cord-028721-x6f26ahr 1646 34 partial partial JJ cord-028721-x6f26ahr 1646 35 testicular testicular JJ cord-028721-x6f26ahr 1646 36 feminization feminization NN cord-028721-x6f26ahr 1646 37 syndrome syndrome NN cord-028721-x6f26ahr 1646 38 , , , cord-028721-x6f26ahr 1646 39 which which WDT cord-028721-x6f26ahr 1646 40 includes include VBZ cord-028721-x6f26ahr 1646 41 the the DT cord-028721-x6f26ahr 1646 42 syndromes syndrome NNS cord-028721-x6f26ahr 1646 43 of of IN cord-028721-x6f26ahr 1646 44 Lubs Lubs NNP cord-028721-x6f26ahr 1646 45 , , , cord-028721-x6f26ahr 1646 46 Gilbert Gilbert NNP cord-028721-x6f26ahr 1646 47 - - HYPH cord-028721-x6f26ahr 1646 48 Dreyfus Dreyfus NNP cord-028721-x6f26ahr 1646 49 , , , cord-028721-x6f26ahr 1646 50 Reifenstein Reifenstein NNP cord-028721-x6f26ahr 1646 51 , , , cord-028721-x6f26ahr 1646 52 and and CC cord-028721-x6f26ahr 1646 53 Rossewater Rossewater NNP cord-028721-x6f26ahr 1646 54 ; ; : cord-028721-x6f26ahr 1646 55 and and CC cord-028721-x6f26ahr 1646 56 mild mild JJ cord-028721-x6f26ahr 1646 57 androgen androgen NN cord-028721-x6f26ahr 1646 58 insensitivity insensitivity NN cord-028721-x6f26ahr 1646 59 syndrome syndrome NN cord-028721-x6f26ahr 1646 60 ( ( -LRB- cord-028721-x6f26ahr 1646 61 MAIS MAIS NNP cord-028721-x6f26ahr 1646 62 ) ) -RRB- cord-028721-x6f26ahr 1646 63 , , , cord-028721-x6f26ahr 1646 64 infertile infertile JJ cord-028721-x6f26ahr 1646 65 men man NNS cord-028721-x6f26ahr 1646 66 with with IN cord-028721-x6f26ahr 1646 67 light light JJ cord-028721-x6f26ahr 1646 68 androgen androgen NN cord-028721-x6f26ahr 1646 69 insensitivity insensitivity NN cord-028721-x6f26ahr 1646 70 , , , cord-028721-x6f26ahr 1646 71 and and CC cord-028721-x6f26ahr 1646 72 Kennedy Kennedy NNP cord-028721-x6f26ahr 1646 73 's 's POS cord-028721-x6f26ahr 1646 74 disease disease NN cord-028721-x6f26ahr 1646 75 . . . cord-028721-x6f26ahr 1647 1 Complete complete JJ cord-028721-x6f26ahr 1647 2 androgen androgen NN cord-028721-x6f26ahr 1647 3 insensitivity insensitivity NN cord-028721-x6f26ahr 1647 4 syndrome syndrome NN cord-028721-x6f26ahr 1647 5 ( ( -LRB- cord-028721-x6f26ahr 1647 6 complete complete JJ cord-028721-x6f26ahr 1647 7 testicular testicular JJ cord-028721-x6f26ahr 1647 8 feminization feminization NN cord-028721-x6f26ahr 1647 9 syndrome syndrome NN cord-028721-x6f26ahr 1647 10 ) ) -RRB- cord-028721-x6f26ahr 1648 1 This this DT cord-028721-x6f26ahr 1648 2 form form NN cord-028721-x6f26ahr 1648 3 of of IN cord-028721-x6f26ahr 1648 4 male male JJ cord-028721-x6f26ahr 1648 5 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1648 6 is be VBZ cord-028721-x6f26ahr 1648 7 characterized characterize VBN cord-028721-x6f26ahr 1648 8 by by IN cord-028721-x6f26ahr 1648 9 female female JJ cord-028721-x6f26ahr 1648 10 phenotype phenotype NN cord-028721-x6f26ahr 1648 11 with with IN cord-028721-x6f26ahr 1648 12 testes testis NNS cord-028721-x6f26ahr 1648 13 . . . cord-028721-x6f26ahr 1649 1 Complete complete JJ cord-028721-x6f26ahr 1649 2 testicular testicular JJ cord-028721-x6f26ahr 1649 3 feminization feminization NN cord-028721-x6f26ahr 1649 4 syndrome syndrome NN cord-028721-x6f26ahr 1649 5 is be VBZ cord-028721-x6f26ahr 1649 6 rarely rarely RB cord-028721-x6f26ahr 1649 7 diagnosed diagnose VBN cord-028721-x6f26ahr 1649 8 during during IN cord-028721-x6f26ahr 1649 9 childhood childhood NN cord-028721-x6f26ahr 1649 10 except except IN cord-028721-x6f26ahr 1649 11 in in IN cord-028721-x6f26ahr 1649 12 patients patient NNS cord-028721-x6f26ahr 1649 13 who who WP cord-028721-x6f26ahr 1649 14 present present VBP cord-028721-x6f26ahr 1649 15 with with IN cord-028721-x6f26ahr 1649 16 hernia hernia NN cord-028721-x6f26ahr 1649 17 , , , cord-028721-x6f26ahr 1649 18 inguinal inguinal JJ cord-028721-x6f26ahr 1649 19 tumor tumor NN cord-028721-x6f26ahr 1649 20 , , , cord-028721-x6f26ahr 1649 21 or or CC cord-028721-x6f26ahr 1649 22 with with IN cord-028721-x6f26ahr 1649 23 a a DT cord-028721-x6f26ahr 1649 24 family family NN cord-028721-x6f26ahr 1649 25 history history NN cord-028721-x6f26ahr 1649 26 of of IN cord-028721-x6f26ahr 1649 27 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1649 28 . . . cord-028721-x6f26ahr 1650 1 Primary primary JJ cord-028721-x6f26ahr 1650 2 amenorrhea amenorrhea NN cord-028721-x6f26ahr 1650 3 is be VBZ cord-028721-x6f26ahr 1650 4 the the DT cord-028721-x6f26ahr 1650 5 principal principal JJ cord-028721-x6f26ahr 1650 6 presentation presentation NN cord-028721-x6f26ahr 1650 7 in in IN cord-028721-x6f26ahr 1650 8 adults adult NNS cord-028721-x6f26ahr 1650 9 . . . cord-028721-x6f26ahr 1651 1 The the DT cord-028721-x6f26ahr 1651 2 testes testis NNS cord-028721-x6f26ahr 1651 3 may may MD cord-028721-x6f26ahr 1651 4 be be VB cord-028721-x6f26ahr 1651 5 in in IN cord-028721-x6f26ahr 1651 6 the the DT cord-028721-x6f26ahr 1651 7 abdomen abdomen NN cord-028721-x6f26ahr 1651 8 , , , cord-028721-x6f26ahr 1651 9 inguinal inguinal JJ cord-028721-x6f26ahr 1651 10 canal canal NN cord-028721-x6f26ahr 1651 11 , , , cord-028721-x6f26ahr 1651 12 or or CC cord-028721-x6f26ahr 1651 13 labia labia NNP cord-028721-x6f26ahr 1651 14 majora majora NNP cord-028721-x6f26ahr 1651 15 , , , cord-028721-x6f26ahr 1651 16 and and CC cord-028721-x6f26ahr 1651 17 during during IN cord-028721-x6f26ahr 1651 18 the the DT cord-028721-x6f26ahr 1651 19 fi fi NNP cord-028721-x6f26ahr 1651 20 rst rst NN cord-028721-x6f26ahr 1651 21 year year NN cord-028721-x6f26ahr 1651 22 of of IN cord-028721-x6f26ahr 1651 23 life life NN cord-028721-x6f26ahr 1651 24 may may MD cord-028721-x6f26ahr 1651 25 be be VB cord-028721-x6f26ahr 1651 26 normal normal JJ cord-028721-x6f26ahr 1651 27 histologically histologically RB cord-028721-x6f26ahr 1651 28 except except IN cord-028721-x6f26ahr 1651 29 for for IN cord-028721-x6f26ahr 1651 30 reduced reduce VBN cord-028721-x6f26ahr 1651 31 tubular tubular JJ cord-028721-x6f26ahr 1651 32 diameter diameter NN cord-028721-x6f26ahr 1651 33 and and CC cord-028721-x6f26ahr 1651 34 low low JJ cord-028721-x6f26ahr 1651 35 tubular tubular JJ cord-028721-x6f26ahr 1651 36 fertility fertility NN cord-028721-x6f26ahr 1651 37 index index NN cord-028721-x6f26ahr 1651 38 . . . cord-028721-x6f26ahr 1652 1 After after IN cord-028721-x6f26ahr 1652 2 the the DT cord-028721-x6f26ahr 1652 3 fi fi NNP cord-028721-x6f26ahr 1652 4 rst rst NNP cord-028721-x6f26ahr 1652 5 year year NN cord-028721-x6f26ahr 1652 6 , , , cord-028721-x6f26ahr 1652 7 decreased decrease VBD cord-028721-x6f26ahr 1652 8 germ germ NN cord-028721-x6f26ahr 1652 9 cell cell NN cord-028721-x6f26ahr 1652 10 numbers number NNS cord-028721-x6f26ahr 1652 11 become become VBP cord-028721-x6f26ahr 1652 12 evident evident JJ cord-028721-x6f26ahr 1652 13 and and CC cord-028721-x6f26ahr 1652 14 the the DT cord-028721-x6f26ahr 1652 15 few few JJ cord-028721-x6f26ahr 1652 16 remaining remain VBG cord-028721-x6f26ahr 1652 17 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1652 18 are be VBP cord-028721-x6f26ahr 1652 19 concentrated concentrate VBN cord-028721-x6f26ahr 1652 20 in in IN cord-028721-x6f26ahr 1652 21 clusters cluster NNS cord-028721-x6f26ahr 1652 22 of of IN cord-028721-x6f26ahr 1652 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 1652 24 tubules tubule NNS cord-028721-x6f26ahr 1652 25 . . . cord-028721-x6f26ahr 1653 1 The the DT cord-028721-x6f26ahr 1653 2 testicular testicular JJ cord-028721-x6f26ahr 1653 3 interstitium interstitium NN cord-028721-x6f26ahr 1653 4 contains contain VBZ cord-028721-x6f26ahr 1653 5 numerous numerous JJ cord-028721-x6f26ahr 1653 6 spindle spindle NN cord-028721-x6f26ahr 1653 7 cells cell NNS cord-028721-x6f26ahr 1653 8 arranged arrange VBN cord-028721-x6f26ahr 1653 9 in in IN cord-028721-x6f26ahr 1653 10 bundles bundle NNS cord-028721-x6f26ahr 1653 11 , , , cord-028721-x6f26ahr 1653 12 and and CC cord-028721-x6f26ahr 1653 13 during during IN cord-028721-x6f26ahr 1653 14 the the DT cord-028721-x6f26ahr 1653 15 fi fi NNP cord-028721-x6f26ahr 1653 16 rst rst NN cord-028721-x6f26ahr 1653 17 year year NN cord-028721-x6f26ahr 1653 18 of of IN cord-028721-x6f26ahr 1653 19 life life NN cord-028721-x6f26ahr 1653 20 has have VBZ cord-028721-x6f26ahr 1653 21 Leydig leydig NN cord-028721-x6f26ahr 1653 22 cells cell NNS cord-028721-x6f26ahr 1653 23 with with IN cord-028721-x6f26ahr 1653 24 abundant abundant JJ cord-028721-x6f26ahr 1653 25 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 1653 26 or or CC cord-028721-x6f26ahr 1653 27 vacuolated vacuolated JJ cord-028721-x6f26ahr 1653 28 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1653 29 . . . cord-028721-x6f26ahr 1654 1 At at IN cord-028721-x6f26ahr 1654 2 puberty puberty NN cord-028721-x6f26ahr 1654 3 , , , cord-028721-x6f26ahr 1654 4 patients patient NNS cord-028721-x6f26ahr 1654 5 have have VBP cord-028721-x6f26ahr 1654 6 female female JJ cord-028721-x6f26ahr 1654 7 external external JJ cord-028721-x6f26ahr 1654 8 genitalia genitalia NNS cord-028721-x6f26ahr 1654 9 , , , cord-028721-x6f26ahr 1654 10 a a DT cord-028721-x6f26ahr 1654 11 short short JJ cord-028721-x6f26ahr 1654 12 blind blind NN cord-028721-x6f26ahr 1654 13 - - HYPH cord-028721-x6f26ahr 1654 14 ended ended JJ cord-028721-x6f26ahr 1654 15 vagina vagina NN cord-028721-x6f26ahr 1654 16 , , , cord-028721-x6f26ahr 1654 17 feminine feminine JJ cord-028721-x6f26ahr 1654 18 breast breast NN cord-028721-x6f26ahr 1654 19 development development NN cord-028721-x6f26ahr 1654 20 ; ; : cord-028721-x6f26ahr 1654 21 and and CC cord-028721-x6f26ahr 1654 22 scarce scarce JJ cord-028721-x6f26ahr 1654 23 pubic pubic NN cord-028721-x6f26ahr 1654 24 and and CC cord-028721-x6f26ahr 1654 25 axillary axillary JJ cord-028721-x6f26ahr 1654 26 hair hair NN cord-028721-x6f26ahr 1654 27 . . . cord-028721-x6f26ahr 1655 1 Serum serum NN cord-028721-x6f26ahr 1655 2 testosterone testosterone NN cord-028721-x6f26ahr 1655 3 is be VBZ cord-028721-x6f26ahr 1655 4 at at IN cord-028721-x6f26ahr 1655 5 the the DT cord-028721-x6f26ahr 1655 6 normal normal JJ cord-028721-x6f26ahr 1655 7 male male JJ cord-028721-x6f26ahr 1655 8 level level NN cord-028721-x6f26ahr 1655 9 and and CC cord-028721-x6f26ahr 1655 10 LH lh NN cord-028721-x6f26ahr 1655 11 is be VBZ cord-028721-x6f26ahr 1655 12 markedly markedly RB cord-028721-x6f26ahr 1655 13 increased increase VBN cord-028721-x6f26ahr 1655 14 . . . cord-028721-x6f26ahr 1656 1 In in IN cord-028721-x6f26ahr 1656 2 adults adult NNS cord-028721-x6f26ahr 1656 3 , , , cord-028721-x6f26ahr 1656 4 the the DT cord-028721-x6f26ahr 1656 5 testes testis NNS cord-028721-x6f26ahr 1656 6 vary vary VBP cord-028721-x6f26ahr 1656 7 in in IN cord-028721-x6f26ahr 1656 8 size size NN cord-028721-x6f26ahr 1656 9 from from IN cord-028721-x6f26ahr 1656 10 small small JJ cord-028721-x6f26ahr 1656 11 to to TO cord-028721-x6f26ahr 1656 12 large large JJ cord-028721-x6f26ahr 1656 13 , , , cord-028721-x6f26ahr 1656 14 are be VBP cord-028721-x6f26ahr 1656 15 tan tan JJ cord-028721-x6f26ahr 1656 16 - - HYPH cord-028721-x6f26ahr 1656 17 brown brown JJ cord-028721-x6f26ahr 1656 18 , , , cord-028721-x6f26ahr 1656 19 and and CC cord-028721-x6f26ahr 1656 20 contain contain VBP cord-028721-x6f26ahr 1656 21 small small JJ cord-028721-x6f26ahr 1656 22 seminiferous seminiferous JJ cord-028721-x6f26ahr 1656 23 tubules tubule NNS cord-028721-x6f26ahr 1656 24 without without IN cord-028721-x6f26ahr 1656 25 lumina lumina NNP cord-028721-x6f26ahr 1656 26 which which WDT cord-028721-x6f26ahr 1656 27 usually usually RB cord-028721-x6f26ahr 1656 28 contain contain VBP cord-028721-x6f26ahr 1656 29 only only RB cord-028721-x6f26ahr 1656 30 Sertoli sertoli JJ cord-028721-x6f26ahr 1656 31 cells cell NNS cord-028721-x6f26ahr 1656 32 . . . cord-028721-x6f26ahr 1657 1 748 748 CD cord-028721-x6f26ahr 1657 2 , , , cord-028721-x6f26ahr 1657 3 749 749 CD cord-028721-x6f26ahr 1658 1 In in IN cord-028721-x6f26ahr 1658 2 one one CD cord-028721-x6f26ahr 1658 3 - - HYPH cord-028721-x6f26ahr 1658 4 third third NN cord-028721-x6f26ahr 1658 5 of of IN cord-028721-x6f26ahr 1658 6 patients patient NNS cord-028721-x6f26ahr 1658 7 both both CC cord-028721-x6f26ahr 1658 8 Sertoli sertoli JJ cord-028721-x6f26ahr 1658 9 cells cell NNS cord-028721-x6f26ahr 1658 10 and and CC cord-028721-x6f26ahr 1658 11 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1658 12 are be VBP cord-028721-x6f26ahr 1658 13 present present JJ cord-028721-x6f26ahr 1658 14 . . . cord-028721-x6f26ahr 1659 1 750 750 CD cord-028721-x6f26ahr 1659 2 Ultrastructurally Ultrastructurally NNP cord-028721-x6f26ahr 1659 3 , , , cord-028721-x6f26ahr 1659 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 1659 5 cells cell NNS cord-028721-x6f26ahr 1659 6 lack lack VBP cord-028721-x6f26ahr 1659 7 Charcot Charcot NNP cord-028721-x6f26ahr 1659 8 - - HYPH cord-028721-x6f26ahr 1659 9 Böttcher Böttcher NNP cord-028721-x6f26ahr 1659 10 crystals crystal NNS cord-028721-x6f26ahr 1659 11 and and CC cord-028721-x6f26ahr 1659 12 annulated annulated JJ cord-028721-x6f26ahr 1659 13 lamellae lamella NNS cord-028721-x6f26ahr 1659 14 ; ; : cord-028721-x6f26ahr 1659 15 inter inter JJ cord-028721-x6f26ahr 1659 16 - - JJ cord-028721-x6f26ahr 1659 17 Sertoli sertoli JJ cord-028721-x6f26ahr 1659 18 cell cell NN cord-028721-x6f26ahr 1659 19 specialized specialize VBN cord-028721-x6f26ahr 1659 20 junctions junction NNS cord-028721-x6f26ahr 1659 21 are be VBP cord-028721-x6f26ahr 1659 22 not not RB cord-028721-x6f26ahr 1659 23 well well RB cord-028721-x6f26ahr 1659 24 developed develop VBN cord-028721-x6f26ahr 1659 25 , , , cord-028721-x6f26ahr 1659 26 and and CC cord-028721-x6f26ahr 1659 27 in in IN cord-028721-x6f26ahr 1659 28 cryofracture cryofracture NNP cord-028721-x6f26ahr 1659 29 studies study VBZ cord-028721-x6f26ahr 1659 30 the the DT cord-028721-x6f26ahr 1659 31 arrangement arrangement NN cord-028721-x6f26ahr 1659 32 of of IN cord-028721-x6f26ahr 1659 33 membrane membrane NN cord-028721-x6f26ahr 1659 34 particles particle NNS cord-028721-x6f26ahr 1659 35 has have VBZ cord-028721-x6f26ahr 1659 36 an an DT cord-028721-x6f26ahr 1659 37 immature immature JJ cord-028721-x6f26ahr 1659 38 pattern pattern NN cord-028721-x6f26ahr 1659 39 . . . cord-028721-x6f26ahr 1660 1 751 751 CD cord-028721-x6f26ahr 1660 2 Leydig Leydig NNP cord-028721-x6f26ahr 1660 3 cells cell NNS cord-028721-x6f26ahr 1660 4 are be VBP cord-028721-x6f26ahr 1660 5 abundant abundant JJ cord-028721-x6f26ahr 1660 6 , , , cord-028721-x6f26ahr 1660 7 but but CC cord-028721-x6f26ahr 1660 8 few few JJ cord-028721-x6f26ahr 1660 9 contain contain VBP cord-028721-x6f26ahr 1660 10 Reinke Reinke NNP cord-028721-x6f26ahr 1660 11 's 's POS cord-028721-x6f26ahr 1660 12 crystalloids crystalloid NNS cord-028721-x6f26ahr 1660 13 . . . cord-028721-x6f26ahr 1661 1 Often often RB cord-028721-x6f26ahr 1661 2 , , , cord-028721-x6f26ahr 1661 3 there there EX cord-028721-x6f26ahr 1661 4 are be VBP cord-028721-x6f26ahr 1661 5 areas area NNS cord-028721-x6f26ahr 1661 6 resembling resemble VBG cord-028721-x6f26ahr 1661 7 ovarian ovarian JJ cord-028721-x6f26ahr 1661 8 stroma stroma NN cord-028721-x6f26ahr 1661 9 in in IN cord-028721-x6f26ahr 1661 10 the the DT cord-028721-x6f26ahr 1661 11 testicular testicular NNP cord-028721-x6f26ahr 1661 12 interstitium interstitium NN cord-028721-x6f26ahr 1661 13 . . . cord-028721-x6f26ahr 1662 1 In in IN cord-028721-x6f26ahr 1662 2 about about RB cord-028721-x6f26ahr 1662 3 two two CD cord-028721-x6f26ahr 1662 4 - - HYPH cord-028721-x6f26ahr 1662 5 thirds third NNS cord-028721-x6f26ahr 1662 6 of of IN cord-028721-x6f26ahr 1662 7 cases case NNS cord-028721-x6f26ahr 1662 8 the the DT cord-028721-x6f26ahr 1662 9 testes testis NNS cord-028721-x6f26ahr 1662 10 contain contain VBP cord-028721-x6f26ahr 1662 11 grossly grossly RB cord-028721-x6f26ahr 1662 12 visible visible JJ cord-028721-x6f26ahr 1662 13 white white JJ cord-028721-x6f26ahr 1662 14 nodules nodule NNS cord-028721-x6f26ahr 1662 15 that that WDT cord-028721-x6f26ahr 1662 16 stand stand VBP cord-028721-x6f26ahr 1662 17 out out RP cord-028721-x6f26ahr 1662 18 from from IN cord-028721-x6f26ahr 1662 19 the the DT cord-028721-x6f26ahr 1662 20 surrounding surround VBG cord-028721-x6f26ahr 1662 21 testicular testicular JJ cord-028721-x6f26ahr 1662 22 parenchyma parenchyma NNS cord-028721-x6f26ahr 1662 23 ( ( -LRB- cord-028721-x6f26ahr 1662 24 Figs Figs NNP cord-028721-x6f26ahr 1662 25 12 12 CD cord-028721-x6f26ahr 1662 26 - - SYM cord-028721-x6f26ahr 1662 27 74 74 CD cord-028721-x6f26ahr 1662 28 , , , cord-028721-x6f26ahr 1662 29 21 21 CD cord-028721-x6f26ahr 1662 30 - - SYM cord-028721-x6f26ahr 1662 31 75 75 CD cord-028721-x6f26ahr 1662 32 ) ) -RRB- cord-028721-x6f26ahr 1662 33 . . . cord-028721-x6f26ahr 1663 1 Histologically histologically RB cord-028721-x6f26ahr 1663 2 , , , cord-028721-x6f26ahr 1663 3 the the DT cord-028721-x6f26ahr 1663 4 nodules nodule NNS cord-028721-x6f26ahr 1663 5 consist consist VBP cord-028721-x6f26ahr 1663 6 of of IN cord-028721-x6f26ahr 1663 7 clusters cluster NNS cord-028721-x6f26ahr 1663 8 of of IN cord-028721-x6f26ahr 1663 9 small small JJ cord-028721-x6f26ahr 1663 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 1663 11 tubules tubule NNS cord-028721-x6f26ahr 1663 12 with with IN cord-028721-x6f26ahr 1663 13 immature immature JJ cord-028721-x6f26ahr 1663 14 Sertoli Sertoli NNP cord-028721-x6f26ahr 1663 15 cells cell NNS cord-028721-x6f26ahr 1663 16 , , , cord-028721-x6f26ahr 1663 17 hyalinized hyalinize VBN cord-028721-x6f26ahr 1663 18 lamina lamina NNP cord-028721-x6f26ahr 1663 19 propria propria NN cord-028721-x6f26ahr 1663 20 , , , cord-028721-x6f26ahr 1663 21 numerous numerous JJ cord-028721-x6f26ahr 1663 22 Leydig Leydig NNP cord-028721-x6f26ahr 1663 23 cells cell NNS cord-028721-x6f26ahr 1663 24 , , , cord-028721-x6f26ahr 1663 25 and and CC cord-028721-x6f26ahr 1663 26 an an DT cord-028721-x6f26ahr 1663 27 absence absence NN cord-028721-x6f26ahr 1663 28 of of IN cord-028721-x6f26ahr 1663 29 elastic elastic JJ cord-028721-x6f26ahr 1663 30 fi fi NN cord-028721-x6f26ahr 1663 31 bers ber NNS cord-028721-x6f26ahr 1663 32 ( ( -LRB- cord-028721-x6f26ahr 1663 33 Fig Fig NNP cord-028721-x6f26ahr 1663 34 . . . cord-028721-x6f26ahr 1663 35 _SP cord-028721-x6f26ahr 1664 1 12 12 CD cord-028721-x6f26ahr 1664 2 - - SYM cord-028721-x6f26ahr 1664 3 76 76 CD cord-028721-x6f26ahr 1664 4 ) ) -RRB- cord-028721-x6f26ahr 1664 5 . . . cord-028721-x6f26ahr 1665 1 These these DT cord-028721-x6f26ahr 1665 2 have have VBP cord-028721-x6f26ahr 1665 3 been be VBN cord-028721-x6f26ahr 1665 4 referred refer VBN cord-028721-x6f26ahr 1665 5 to to IN cord-028721-x6f26ahr 1665 6 as as IN cord-028721-x6f26ahr 1665 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 1665 8 - - HYPH cord-028721-x6f26ahr 1665 9 Leydig leydig NN cord-028721-x6f26ahr 1665 10 cell cell NN cord-028721-x6f26ahr 1665 11 hamartoma hamartoma NN cord-028721-x6f26ahr 1665 12 . . . cord-028721-x6f26ahr 1666 1 About about RB cord-028721-x6f26ahr 1666 2 25 25 CD cord-028721-x6f26ahr 1666 3 % % NN cord-028721-x6f26ahr 1666 4 of of IN cord-028721-x6f26ahr 1666 5 testes testis NNS cord-028721-x6f26ahr 1666 6 have have VBP cord-028721-x6f26ahr 1666 7 Sertoli sertoli JJ cord-028721-x6f26ahr 1666 8 cell cell NN cord-028721-x6f26ahr 1666 9 adenoma adenoma NN cord-028721-x6f26ahr 1666 10 , , , cord-028721-x6f26ahr 1666 11 sometimes sometimes RB cord-028721-x6f26ahr 1666 12 very very RB cord-028721-x6f26ahr 1666 13 large large JJ cord-028721-x6f26ahr 1666 14 , , , cord-028721-x6f26ahr 1666 15 consisting consist VBG cord-028721-x6f26ahr 1666 16 of of IN cord-028721-x6f26ahr 1666 17 tubules tubule NNS cord-028721-x6f26ahr 1666 18 resembling resemble VBG cord-028721-x6f26ahr 1666 19 infantile infantile JJ cord-028721-x6f26ahr 1666 20 testis testis NN cord-028721-x6f26ahr 1666 21 but but CC cord-028721-x6f26ahr 1666 22 lacking lack VBG cord-028721-x6f26ahr 1666 23 in in IN cord-028721-x6f26ahr 1666 24 germ germ NN cord-028721-x6f26ahr 1666 25 cells cell NNS cord-028721-x6f26ahr 1666 26 and and CC cord-028721-x6f26ahr 1666 27 peritubular peritubular NNP cord-028721-x6f26ahr 1666 28 myofi myofi NNP cord-028721-x6f26ahr 1666 29 broblasts broblasts NNP cord-028721-x6f26ahr 1666 30 . . . cord-028721-x6f26ahr 1667 1 No no DT cord-028721-x6f26ahr 1667 2 Leydig Leydig NNP cord-028721-x6f26ahr 1667 3 cells cell NNS cord-028721-x6f26ahr 1667 4 are be VBP cord-028721-x6f26ahr 1667 5 present present JJ cord-028721-x6f26ahr 1667 6 between between IN cord-028721-x6f26ahr 1667 7 the the DT cord-028721-x6f26ahr 1667 8 tubules tubule NNS cord-028721-x6f26ahr 1667 9 ( ( -LRB- cord-028721-x6f26ahr 1667 10 Figs Figs NNP cord-028721-x6f26ahr 1667 11 12 12 CD cord-028721-x6f26ahr 1667 12 - - SYM cord-028721-x6f26ahr 1667 13 77 77 CD cord-028721-x6f26ahr 1667 14 , , , cord-028721-x6f26ahr 1667 15 12 12 CD cord-028721-x6f26ahr 1667 16 - - SYM cord-028721-x6f26ahr 1667 17 78 78 CD cord-028721-x6f26ahr 1667 18 ) ) -RRB- cord-028721-x6f26ahr 1667 19 . . . cord-028721-x6f26ahr 1668 1 752 752 CD cord-028721-x6f26ahr 1669 1 Other other JJ cord-028721-x6f26ahr 1669 2 benign benign JJ cord-028721-x6f26ahr 1669 3 tumors tumor NNS cord-028721-x6f26ahr 1669 4 include include VBP cord-028721-x6f26ahr 1669 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 1669 6 cell cell NN cord-028721-x6f26ahr 1669 7 tumor tumor NN cord-028721-x6f26ahr 1669 8 ( ( -LRB- cord-028721-x6f26ahr 1669 9 large large JJ cord-028721-x6f26ahr 1669 10 cell cell NN cord-028721-x6f26ahr 1669 11 calcifying calcify VBG cord-028721-x6f26ahr 1669 12 Sertoli sertoli JJ cord-028721-x6f26ahr 1669 13 cell cell NN cord-028721-x6f26ahr 1669 14 tumor tumor NN cord-028721-x6f26ahr 1669 15 and and CC cord-028721-x6f26ahr 1669 16 sex sex NN cord-028721-x6f26ahr 1669 17 cord cord NN cord-028721-x6f26ahr 1669 18 tumor tumor NN cord-028721-x6f26ahr 1669 19 with with IN cord-028721-x6f26ahr 1669 20 annular annular JJ cord-028721-x6f26ahr 1669 21 tubules tubule NNS cord-028721-x6f26ahr 1669 22 ) ) -RRB- cord-028721-x6f26ahr 1669 23 , , , cord-028721-x6f26ahr 1669 24 Leydig leydig NN cord-028721-x6f26ahr 1669 25 cell cell NN cord-028721-x6f26ahr 1669 26 tumor tumor NN cord-028721-x6f26ahr 1669 27 , , , cord-028721-x6f26ahr 1669 28 leiomyoma leiomyoma NNP cord-028721-x6f26ahr 1669 29 , , , cord-028721-x6f26ahr 1669 30 and and CC cord-028721-x6f26ahr 1669 31 fi fi NNP cord-028721-x6f26ahr 1669 32 broma broma NNP cord-028721-x6f26ahr 1669 33 . . . cord-028721-x6f26ahr 1670 1 746 746 CD cord-028721-x6f26ahr 1671 1 Approximately approximately RB cord-028721-x6f26ahr 1671 2 60 60 CD cord-028721-x6f26ahr 1671 3 % % NN cord-028721-x6f26ahr 1671 4 of of IN cord-028721-x6f26ahr 1671 5 cases case NNS cord-028721-x6f26ahr 1671 6 have have VBP cord-028721-x6f26ahr 1671 7 small small JJ cord-028721-x6f26ahr 1671 8 cystic cystic JJ cord-028721-x6f26ahr 1671 9 structures structure NNS cord-028721-x6f26ahr 1671 10 closely closely RB cord-028721-x6f26ahr 1671 11 apposed apposed JJ cord-028721-x6f26ahr 1671 12 to to IN cord-028721-x6f26ahr 1671 13 the the DT cord-028721-x6f26ahr 1671 14 testes testis NNS cord-028721-x6f26ahr 1671 15 , , , cord-028721-x6f26ahr 1671 16 and and CC cord-028721-x6f26ahr 1671 17 about about RB cord-028721-x6f26ahr 1671 18 80 80 CD cord-028721-x6f26ahr 1671 19 % % NN cord-028721-x6f26ahr 1671 20 of of IN cord-028721-x6f26ahr 1671 21 patients patient NNS cord-028721-x6f26ahr 1671 22 have have VBP cord-028721-x6f26ahr 1671 23 thick thick JJ cord-028721-x6f26ahr 1671 24 bundles bundle NNS cord-028721-x6f26ahr 1671 25 of of IN cord-028721-x6f26ahr 1671 26 smooth smooth JJ cord-028721-x6f26ahr 1671 27 muscle muscle NN cord-028721-x6f26ahr 1671 28 fi fi NN cord-028721-x6f26ahr 1671 29 bers ber NNS cord-028721-x6f26ahr 1671 30 resembling resemble VBG cord-028721-x6f26ahr 1671 31 myo- myo- NNP cord-028721-x6f26ahr 1671 32 metrium metrium NNP cord-028721-x6f26ahr 1671 33 near near IN cord-028721-x6f26ahr 1671 34 the the DT cord-028721-x6f26ahr 1671 35 testis testis NN cord-028721-x6f26ahr 1671 36 . . . cord-028721-x6f26ahr 1672 1 True true JJ cord-028721-x6f26ahr 1672 2 myometrium myometrium NN cord-028721-x6f26ahr 1672 3 has have VBZ cord-028721-x6f26ahr 1672 4 been be VBN cord-028721-x6f26ahr 1672 5 demonstrated demonstrate VBN cord-028721-x6f26ahr 1672 6 in in IN cord-028721-x6f26ahr 1672 7 only only RB cord-028721-x6f26ahr 1672 8 one one CD cord-028721-x6f26ahr 1672 9 case case NN cord-028721-x6f26ahr 1672 10 . . . cord-028721-x6f26ahr 1673 1 Hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1673 2 fallopian fallopian NN cord-028721-x6f26ahr 1673 3 tubes tube NNS cord-028721-x6f26ahr 1673 4 are be VBP cord-028721-x6f26ahr 1673 5 present present JJ cord-028721-x6f26ahr 1673 6 in in IN cord-028721-x6f26ahr 1673 7 about about RB cord-028721-x6f26ahr 1673 8 one one CD cord-028721-x6f26ahr 1673 9 - - HYPH cord-028721-x6f26ahr 1673 10 third third NN cord-028721-x6f26ahr 1673 11 of of IN cord-028721-x6f26ahr 1673 12 cases case NNS cord-028721-x6f26ahr 1673 13 . . . cord-028721-x6f26ahr 1674 1 In in IN cord-028721-x6f26ahr 1674 2 about about RB cord-028721-x6f26ahr 1674 3 70 70 CD cord-028721-x6f26ahr 1674 4 % % NN cord-028721-x6f26ahr 1674 5 of of IN cord-028721-x6f26ahr 1674 6 patients patient NNS cord-028721-x6f26ahr 1674 7 the the DT cord-028721-x6f26ahr 1674 8 epididymis epididymis NN cord-028721-x6f26ahr 1674 9 and and CC cord-028721-x6f26ahr 1674 10 vas vas NNP cord-028721-x6f26ahr 1674 11 deferens deferen NNS cord-028721-x6f26ahr 1674 12 are be VBP cord-028721-x6f26ahr 1674 13 rudimentary rudimentary JJ cord-028721-x6f26ahr 1674 14 ; ; : cord-028721-x6f26ahr 1674 15 the the DT cord-028721-x6f26ahr 1674 16 only only JJ cord-028721-x6f26ahr 1674 17 explanation explanation NN cord-028721-x6f26ahr 1674 18 for for IN cord-028721-x6f26ahr 1674 19 this this DT cord-028721-x6f26ahr 1674 20 is be VBZ cord-028721-x6f26ahr 1674 21 residual residual JJ cord-028721-x6f26ahr 1674 22 activity activity NN cord-028721-x6f26ahr 1674 23 of of IN cord-028721-x6f26ahr 1674 24 the the DT cord-028721-x6f26ahr 1674 25 mutated mutate VBN cord-028721-x6f26ahr 1674 26 androgen androgen NN cord-028721-x6f26ahr 1674 27 receptor receptor NN cord-028721-x6f26ahr 1674 28 . . . cord-028721-x6f26ahr 1675 1 753 753 CD cord-028721-x6f26ahr 1675 2 Approximately approximately RB cord-028721-x6f26ahr 1675 3 10 10 CD cord-028721-x6f26ahr 1675 4 % % NN cord-028721-x6f26ahr 1675 5 of of IN cord-028721-x6f26ahr 1675 6 testes testis NNS cord-028721-x6f26ahr 1675 7 from from IN cord-028721-x6f26ahr 1675 8 patients patient NNS cord-028721-x6f26ahr 1675 9 with with IN cord-028721-x6f26ahr 1675 10 testicular testicular JJ cord-028721-x6f26ahr 1675 11 feminization feminization NN cord-028721-x6f26ahr 1675 12 syndrome syndrome NN cord-028721-x6f26ahr 1675 13 develop develop VB cord-028721-x6f26ahr 1675 14 cancer cancer NN cord-028721-x6f26ahr 1675 15 . . . cord-028721-x6f26ahr 1676 1 The the DT cord-028721-x6f26ahr 1676 2 frequency frequency NN cord-028721-x6f26ahr 1676 3 increases increase VBZ cord-028721-x6f26ahr 1676 4 with with IN cord-028721-x6f26ahr 1676 5 age age NN cord-028721-x6f26ahr 1676 6 , , , cord-028721-x6f26ahr 1676 7 but but CC cord-028721-x6f26ahr 1676 8 tumors tumor NNS cord-028721-x6f26ahr 1676 9 rarely rarely RB cord-028721-x6f26ahr 1676 10 appear appear VBP cord-028721-x6f26ahr 1676 11 before before IN cord-028721-x6f26ahr 1676 12 puberty puberty NN cord-028721-x6f26ahr 1676 13 . . . cord-028721-x6f26ahr 1677 1 These these DT cord-028721-x6f26ahr 1677 2 tumors tumor NNS cord-028721-x6f26ahr 1677 3 include include VBP cord-028721-x6f26ahr 1677 4 intratubular intratubular JJ cord-028721-x6f26ahr 1677 5 germ germ NN cord-028721-x6f26ahr 1677 6 cell cell NN cord-028721-x6f26ahr 1677 7 neoplasia neoplasia NN cord-028721-x6f26ahr 1677 8 ( ( -LRB- cord-028721-x6f26ahr 1677 9 Fig fig NN cord-028721-x6f26ahr 1677 10 . . . cord-028721-x6f26ahr 1677 11 12 12 CD cord-028721-x6f26ahr 1677 12 - - SYM cord-028721-x6f26ahr 1677 13 79 79 CD cord-028721-x6f26ahr 1677 14 ) ) -RRB- cord-028721-x6f26ahr 1677 15 , , , cord-028721-x6f26ahr 1677 16 749 749 CD cord-028721-x6f26ahr 1677 17 several several JJ cord-028721-x6f26ahr 1677 18 types type NNS cord-028721-x6f26ahr 1677 19 of of IN cord-028721-x6f26ahr 1677 20 germ germ NN cord-028721-x6f26ahr 1677 21 cell cell NN cord-028721-x6f26ahr 1677 22 tumor tumor NN cord-028721-x6f26ahr 1677 23 , , , cord-028721-x6f26ahr 1677 24 750 750 CD cord-028721-x6f26ahr 1677 25 , , , cord-028721-x6f26ahr 1677 26 754 754 CD cord-028721-x6f26ahr 1677 27 and and CC cord-028721-x6f26ahr 1677 28 sex sex NN cord-028721-x6f26ahr 1677 29 cord cord NN cord-028721-x6f26ahr 1677 30 tumor tumor NN cord-028721-x6f26ahr 1677 31 . . . cord-028721-x6f26ahr 1678 1 441 441 CD cord-028721-x6f26ahr 1679 1 Thus thus RB cord-028721-x6f26ahr 1679 2 , , , cord-028721-x6f26ahr 1679 3 the the DT cord-028721-x6f26ahr 1679 4 gonads gonad NNS cord-028721-x6f26ahr 1679 5 should should MD cord-028721-x6f26ahr 1679 6 be be VB cord-028721-x6f26ahr 1679 7 removed remove VBN cord-028721-x6f26ahr 1679 8 immediately immediately RB cord-028721-x6f26ahr 1679 9 after after IN cord-028721-x6f26ahr 1679 10 puberty puberty NN cord-028721-x6f26ahr 1679 11 . . . cord-028721-x6f26ahr 1680 1 755 755 CD cord-028721-x6f26ahr 1680 2 Partial partial JJ cord-028721-x6f26ahr 1680 3 androgen androgen NN cord-028721-x6f26ahr 1680 4 insensitivity insensitivity NN cord-028721-x6f26ahr 1680 5 syndrome syndrome NN cord-028721-x6f26ahr 1680 6 ( ( -LRB- cord-028721-x6f26ahr 1680 7 partial partial JJ cord-028721-x6f26ahr 1680 8 testicular testicular JJ cord-028721-x6f26ahr 1680 9 feminization feminization NN cord-028721-x6f26ahr 1680 10 syndrome syndrome NN cord-028721-x6f26ahr 1680 11 ) ) -RRB- cord-028721-x6f26ahr 1681 1 The the DT cord-028721-x6f26ahr 1681 2 phenotype phenotype NN cord-028721-x6f26ahr 1681 3 of of IN cord-028721-x6f26ahr 1681 4 patients patient NNS cord-028721-x6f26ahr 1681 5 with with IN cord-028721-x6f26ahr 1681 6 partial partial JJ cord-028721-x6f26ahr 1681 7 testicular testicular JJ cord-028721-x6f26ahr 1681 8 feminization feminization NN cord-028721-x6f26ahr 1681 9 varies vary VBZ cord-028721-x6f26ahr 1681 10 from from IN cord-028721-x6f26ahr 1681 11 normal normal JJ cord-028721-x6f26ahr 1681 12 female female NN cord-028721-x6f26ahr 1681 13 to to IN cord-028721-x6f26ahr 1681 14 normal normal JJ cord-028721-x6f26ahr 1681 15 male male NN cord-028721-x6f26ahr 1681 16 . . . cord-028721-x6f26ahr 1682 1 The the DT cord-028721-x6f26ahr 1682 2 disorder disorder NN cord-028721-x6f26ahr 1682 3 includes include VBZ cord-028721-x6f26ahr 1682 4 four four CD cord-028721-x6f26ahr 1682 5 classic classic JJ cord-028721-x6f26ahr 1682 6 syndromes syndrome NNS cord-028721-x6f26ahr 1682 7 : : : cord-028721-x6f26ahr 1683 1 Lubs Lubs NNP cord-028721-x6f26ahr 1683 2 ' ' POS cord-028721-x6f26ahr 1683 3 syndrome syndrome NN cord-028721-x6f26ahr 1683 4 , , , cord-028721-x6f26ahr 1683 5 756 756 CD cord-028721-x6f26ahr 1683 6 characterized characterize VBN cord-028721-x6f26ahr 1683 7 by by IN cord-028721-x6f26ahr 1683 8 partial partial JJ cord-028721-x6f26ahr 1683 9 fusion fusion NN cord-028721-x6f26ahr 1683 10 of of IN cord-028721-x6f26ahr 1683 11 labioscrotal labioscrotal JJ cord-028721-x6f26ahr 1683 12 folds fold VBZ cord-028721-x6f26ahr 1683 13 , , , cord-028721-x6f26ahr 1683 14 a a DT cord-028721-x6f26ahr 1683 15 defi defi FW cord-028721-x6f26ahr 1683 16 nitive nitive JJ cord-028721-x6f26ahr 1683 17 introitus introitus NN cord-028721-x6f26ahr 1683 18 , , , cord-028721-x6f26ahr 1683 19 clitoromegaly clitoromegaly NNP cord-028721-x6f26ahr 1683 20 , , , cord-028721-x6f26ahr 1683 21 pubic pubic NN cord-028721-x6f26ahr 1683 22 and and CC cord-028721-x6f26ahr 1683 23 axillary axillary JJ cord-028721-x6f26ahr 1683 24 hair hair NN cord-028721-x6f26ahr 1683 25 , , , cord-028721-x6f26ahr 1683 26 and and CC cord-028721-x6f26ahr 1683 27 poor poor JJ cord-028721-x6f26ahr 1683 28 breast breast NN cord-028721-x6f26ahr 1683 29 development development NN cord-028721-x6f26ahr 1683 30 ; ; : cord-028721-x6f26ahr 1683 31 757 757 NNP cord-028721-x6f26ahr 1683 32 Gilbert Gilbert NNP cord-028721-x6f26ahr 1683 33 - - HYPH cord-028721-x6f26ahr 1683 34 Dreyfus Dreyfus NNP cord-028721-x6f26ahr 1683 35 syndrome syndrome NN cord-028721-x6f26ahr 1683 36 , , , cord-028721-x6f26ahr 1683 37 characterized characterize VBN cord-028721-x6f26ahr 1683 38 by by IN cord-028721-x6f26ahr 1683 39 progressively progressively RB cord-028721-x6f26ahr 1683 40 greater great JJR cord-028721-x6f26ahr 1683 41 male male JJ cord-028721-x6f26ahr 1683 42 phenotypic phenotypic NN cord-028721-x6f26ahr 1683 43 features feature NNS cord-028721-x6f26ahr 1683 44 that that WDT cord-028721-x6f26ahr 1683 45 include include VBP cord-028721-x6f26ahr 1683 46 small small JJ cord-028721-x6f26ahr 1683 47 phallus phallus NN cord-028721-x6f26ahr 1683 48 , , , cord-028721-x6f26ahr 1683 49 hypospadias hypospadia NNS cord-028721-x6f26ahr 1683 50 , , , cord-028721-x6f26ahr 1683 51 incomplete incomplete JJ cord-028721-x6f26ahr 1683 52 development development NN cord-028721-x6f26ahr 1683 53 of of IN cord-028721-x6f26ahr 1683 54 wolffi wolffi NNP cord-028721-x6f26ahr 1683 55 an an DT cord-028721-x6f26ahr 1683 56 derivatives derivative NNS cord-028721-x6f26ahr 1683 57 , , , cord-028721-x6f26ahr 1683 58 and and CC cord-028721-x6f26ahr 1683 59 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1683 60 ; ; : cord-028721-x6f26ahr 1683 61 758 758 CD cord-028721-x6f26ahr 1683 62 Reifenstein Reifenstein NNP cord-028721-x6f26ahr 1683 63 's 's POS cord-028721-x6f26ahr 1683 64 syndrome syndrome NN cord-028721-x6f26ahr 1683 65 , , , cord-028721-x6f26ahr 1683 66 characterized characterize VBN cord-028721-x6f26ahr 1683 67 by by IN cord-028721-x6f26ahr 1683 68 hypospadias hypospadia NNS cord-028721-x6f26ahr 1683 69 , , , cord-028721-x6f26ahr 1683 70 weak weak JJ cord-028721-x6f26ahr 1683 71 or or CC cord-028721-x6f26ahr 1683 72 absent absent JJ cord-028721-x6f26ahr 1683 73 virilization virilization NN cord-028721-x6f26ahr 1683 74 , , , cord-028721-x6f26ahr 1683 75 testicular testicular JJ cord-028721-x6f26ahr 1683 76 atrophy atrophy NN cord-028721-x6f26ahr 1683 77 , , , cord-028721-x6f26ahr 1683 78 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1683 79 , , , cord-028721-x6f26ahr 1683 80 azoospermia azoospermia NN cord-028721-x6f26ahr 1683 81 , , , cord-028721-x6f26ahr 1683 82 and and CC cord-028721-x6f26ahr 1683 83 infertility infertility NN cord-028721-x6f26ahr 1683 84 ; ; : cord-028721-x6f26ahr 1683 85 759 759 CD cord-028721-x6f26ahr 1683 86 and and CC cord-028721-x6f26ahr 1683 87 Rosewater Rosewater NNP cord-028721-x6f26ahr 1683 88 - - HYPH cord-028721-x6f26ahr 1683 89 Gwinup Gwinup NNP cord-028721-x6f26ahr 1683 90 - - HYPH cord-028721-x6f26ahr 1683 91 Hamwi Hamwi NNP cord-028721-x6f26ahr 1683 92 syndrome syndrome NN cord-028721-x6f26ahr 1683 93 , , , cord-028721-x6f26ahr 1683 94 characterized characterize VBN cord-028721-x6f26ahr 1683 95 by by IN cord-028721-x6f26ahr 1683 96 infertile infertile JJ cord-028721-x6f26ahr 1683 97 men man NNS cord-028721-x6f26ahr 1683 98 whose whose WP$ cord-028721-x6f26ahr 1683 99 only only JJ cord-028721-x6f26ahr 1683 100 abnormal abnormal JJ cord-028721-x6f26ahr 1683 101 feature feature NN cord-028721-x6f26ahr 1683 102 is be VBZ cord-028721-x6f26ahr 1683 103 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1683 104 . . . cord-028721-x6f26ahr 1684 1 760 760 CD cord-028721-x6f26ahr 1684 2 Mild mild JJ cord-028721-x6f26ahr 1684 3 androgen androgen NN cord-028721-x6f26ahr 1684 4 insensitivity insensitivity NN cord-028721-x6f26ahr 1684 5 syndrome syndrome NN cord-028721-x6f26ahr 1684 6 Spermatogenesis Spermatogenesis NNP cord-028721-x6f26ahr 1684 7 requires require VBZ cord-028721-x6f26ahr 1684 8 high high JJ cord-028721-x6f26ahr 1684 9 levels level NNS cord-028721-x6f26ahr 1684 10 of of IN cord-028721-x6f26ahr 1684 11 intratesticular intratesticular JJ cord-028721-x6f26ahr 1684 12 testosterone testosterone NN cord-028721-x6f26ahr 1684 13 . . . cord-028721-x6f26ahr 1685 1 A a DT cord-028721-x6f26ahr 1685 2 minor minor JJ cord-028721-x6f26ahr 1685 3 form form NN cord-028721-x6f26ahr 1685 4 of of IN cord-028721-x6f26ahr 1685 5 androgen androgen NN cord-028721-x6f26ahr 1685 6 insensitivity insensitivity NN cord-028721-x6f26ahr 1685 7 may may MD cord-028721-x6f26ahr 1685 8 be be VB cord-028721-x6f26ahr 1685 9 observed observe VBN cord-028721-x6f26ahr 1685 10 in in IN cord-028721-x6f26ahr 1685 11 some some DT cord-028721-x6f26ahr 1685 12 patients patient NNS cord-028721-x6f26ahr 1685 13 with with IN cord-028721-x6f26ahr 1685 14 male male JJ cord-028721-x6f26ahr 1685 15 phenotype phenotype NN cord-028721-x6f26ahr 1685 16 who who WP cord-028721-x6f26ahr 1685 17 present present VBP cord-028721-x6f26ahr 1685 18 with with IN cord-028721-x6f26ahr 1685 19 infertility infertility NN cord-028721-x6f26ahr 1685 20 . . . cord-028721-x6f26ahr 1686 1 761 761 CD cord-028721-x6f26ahr 1687 1 The the DT cord-028721-x6f26ahr 1687 2 frequency frequency NN cord-028721-x6f26ahr 1687 3 of of IN cord-028721-x6f26ahr 1687 4 androgen androgen NN cord-028721-x6f26ahr 1687 5 resistance resistance NN cord-028721-x6f26ahr 1687 6 among among IN cord-028721-x6f26ahr 1687 7 azoospermic azoospermic NNP cord-028721-x6f26ahr 1687 8 and and CC cord-028721-x6f26ahr 1687 9 oligozoospermic oligozoospermic NNP cord-028721-x6f26ahr 1687 10 men man NNS cord-028721-x6f26ahr 1687 11 is be VBZ cord-028721-x6f26ahr 1687 12 estimated estimate VBN cord-028721-x6f26ahr 1687 13 at at IN cord-028721-x6f26ahr 1687 14 about about RB cord-028721-x6f26ahr 1687 15 19 19 CD cord-028721-x6f26ahr 1687 16 % % NN cord-028721-x6f26ahr 1687 17 762 762 CD cord-028721-x6f26ahr 1687 18 or or CC cord-028721-x6f26ahr 1687 19 lower low JJR cord-028721-x6f26ahr 1687 20 . . . cord-028721-x6f26ahr 1688 1 763 763 CD cord-028721-x6f26ahr 1688 2 , , , cord-028721-x6f26ahr 1688 3 764 764 CD cord-028721-x6f26ahr 1689 1 Some some DT cord-028721-x6f26ahr 1689 2 patients patient NNS cord-028721-x6f26ahr 1689 3 have have VBP cord-028721-x6f26ahr 1689 4 lost lose VBN cord-028721-x6f26ahr 1689 5 exon exon NN cord-028721-x6f26ahr 1689 6 4 4 CD cord-028721-x6f26ahr 1689 7 765 765 CD cord-028721-x6f26ahr 1689 8 or or CC cord-028721-x6f26ahr 1689 9 mutated mutate VBN cord-028721-x6f26ahr 1689 10 exons exon NNS cord-028721-x6f26ahr 1689 11 6 6 CD cord-028721-x6f26ahr 1689 12 764 764 CD cord-028721-x6f26ahr 1689 13 or or CC cord-028721-x6f26ahr 1689 14 7 7 CD cord-028721-x6f26ahr 1689 15 . . . cord-028721-x6f26ahr 1690 1 766 766 CD cord-028721-x6f26ahr 1691 1 Kennedy Kennedy NNP cord-028721-x6f26ahr 1691 2 's 's POS cord-028721-x6f26ahr 1691 3 disease disease NN cord-028721-x6f26ahr 1691 4 Kennedy Kennedy NNP cord-028721-x6f26ahr 1691 5 's 's POS cord-028721-x6f26ahr 1691 6 disease disease NN cord-028721-x6f26ahr 1691 7 ( ( -LRB- cord-028721-x6f26ahr 1691 8 spinal spinal JJ cord-028721-x6f26ahr 1691 9 and and CC cord-028721-x6f26ahr 1691 10 bulbar bulbar JJ cord-028721-x6f26ahr 1691 11 muscular muscular JJ cord-028721-x6f26ahr 1691 12 atrophy atrophy NN cord-028721-x6f26ahr 1691 13 , , , cord-028721-x6f26ahr 1691 14 SBMA SBMA NNP cord-028721-x6f26ahr 1691 15 ) ) -RRB- cord-028721-x6f26ahr 1691 16 is be VBZ cord-028721-x6f26ahr 1691 17 an an DT cord-028721-x6f26ahr 1691 18 X x NN cord-028721-x6f26ahr 1691 19 - - HYPH cord-028721-x6f26ahr 1691 20 linked link VBN cord-028721-x6f26ahr 1691 21 recessive recessive JJ cord-028721-x6f26ahr 1691 22 disorder disorder NN cord-028721-x6f26ahr 1691 23 of of IN cord-028721-x6f26ahr 1691 24 the the DT cord-028721-x6f26ahr 1691 25 adult adult NN cord-028721-x6f26ahr 1691 26 male male NN cord-028721-x6f26ahr 1691 27 767,768 767,768 CD cord-028721-x6f26ahr 1691 28 characterized characterize VBN cord-028721-x6f26ahr 1691 29 by by IN cord-028721-x6f26ahr 1691 30 loss loss NN cord-028721-x6f26ahr 1691 31 of of IN cord-028721-x6f26ahr 1691 32 motor motor NN cord-028721-x6f26ahr 1691 33 neurons neuron NNS cord-028721-x6f26ahr 1691 34 in in IN cord-028721-x6f26ahr 1691 35 the the DT cord-028721-x6f26ahr 1691 36 spinal spinal JJ cord-028721-x6f26ahr 1691 37 cord cord NN cord-028721-x6f26ahr 1691 38 and and CC cord-028721-x6f26ahr 1691 39 brain brain NN cord-028721-x6f26ahr 1691 40 stem stem NN cord-028721-x6f26ahr 1691 41 and and CC cord-028721-x6f26ahr 1691 42 associated associate VBN cord-028721-x6f26ahr 1691 43 with with IN cord-028721-x6f26ahr 1691 44 less less RBR cord-028721-x6f26ahr 1691 45 important important JJ cord-028721-x6f26ahr 1691 46 loss loss NN cord-028721-x6f26ahr 1691 47 of of IN cord-028721-x6f26ahr 1691 48 sensory sensory JJ cord-028721-x6f26ahr 1691 49 neurons neuron NNS cord-028721-x6f26ahr 1691 50 and and CC cord-028721-x6f26ahr 1691 51 atrophy atrophy NN cord-028721-x6f26ahr 1691 52 caused cause VBN cord-028721-x6f26ahr 1691 53 by by IN cord-028721-x6f26ahr 1691 54 skeletal skeletal JJ cord-028721-x6f26ahr 1691 55 muscle muscle NN cord-028721-x6f26ahr 1691 56 denervation denervation NN cord-028721-x6f26ahr 1691 57 . . . cord-028721-x6f26ahr 1692 1 767 767 CD cord-028721-x6f26ahr 1692 2 , , , cord-028721-x6f26ahr 1692 3 769 769 CD cord-028721-x6f26ahr 1692 4 Disease Disease NNP cord-028721-x6f26ahr 1692 5 onset onset NN cord-028721-x6f26ahr 1693 1 around around IN cord-028721-x6f26ahr 1693 2 20 20 CD cord-028721-x6f26ahr 1693 3 years year NNS cord-028721-x6f26ahr 1693 4 of of IN cord-028721-x6f26ahr 1693 5 age age NN cord-028721-x6f26ahr 1693 6 includes include VBZ cord-028721-x6f26ahr 1693 7 muscular muscular JJ cord-028721-x6f26ahr 1693 8 weakness weakness NN cord-028721-x6f26ahr 1693 9 , , , cord-028721-x6f26ahr 1693 10 cramps cramp NNS cord-028721-x6f26ahr 1693 11 , , , cord-028721-x6f26ahr 1693 12 and and CC cord-028721-x6f26ahr 1693 13 fasciculations fasciculation NNS cord-028721-x6f26ahr 1693 14 . . . cord-028721-x6f26ahr 1694 1 770 770 CD cord-028721-x6f26ahr 1695 1 In in IN cord-028721-x6f26ahr 1695 2 most most JJS cord-028721-x6f26ahr 1695 3 cases case NNS cord-028721-x6f26ahr 1695 4 the the DT cord-028721-x6f26ahr 1695 5 male male JJ cord-028721-x6f26ahr 1695 6 reproductive reproductive JJ cord-028721-x6f26ahr 1695 7 system system NN cord-028721-x6f26ahr 1695 8 is be VBZ cord-028721-x6f26ahr 1695 9 impaired impair VBN cord-028721-x6f26ahr 1695 10 . . . cord-028721-x6f26ahr 1696 1 [ [ -LRB- cord-028721-x6f26ahr 1696 2 770 770 CD cord-028721-x6f26ahr 1696 3 ] ] -RRB- cord-028721-x6f26ahr 1696 4 [ [ -LRB- cord-028721-x6f26ahr 1696 5 771 771 CD cord-028721-x6f26ahr 1696 6 ] ] -RRB- cord-028721-x6f26ahr 1697 1 [ [ -LRB- cord-028721-x6f26ahr 1697 2 772 772 CD cord-028721-x6f26ahr 1697 3 ] ] -RRB- cord-028721-x6f26ahr 1698 1 The the DT cord-028721-x6f26ahr 1698 2 testes testis NNS cord-028721-x6f26ahr 1698 3 may may MD cord-028721-x6f26ahr 1698 4 be be VB cord-028721-x6f26ahr 1698 5 normal normal JJ cord-028721-x6f26ahr 1698 6 in in IN cord-028721-x6f26ahr 1698 7 the the DT cord-028721-x6f26ahr 1698 8 initial initial JJ cord-028721-x6f26ahr 1698 9 stages stage NNS cord-028721-x6f26ahr 1698 10 of of IN cord-028721-x6f26ahr 1698 11 the the DT cord-028721-x6f26ahr 1698 12 disease disease NN cord-028721-x6f26ahr 1698 13 , , , cord-028721-x6f26ahr 1698 14 and and CC cord-028721-x6f26ahr 1698 15 many many JJ cord-028721-x6f26ahr 1698 16 patients patient NNS cord-028721-x6f26ahr 1698 17 are be VBP cord-028721-x6f26ahr 1698 18 fertile fertile JJ cord-028721-x6f26ahr 1698 19 ; ; : cord-028721-x6f26ahr 1698 20 however however RB cord-028721-x6f26ahr 1698 21 , , , cord-028721-x6f26ahr 1698 22 with with IN cord-028721-x6f26ahr 1698 23 progression progression NN cord-028721-x6f26ahr 1698 24 , , , cord-028721-x6f26ahr 1698 25 there there EX cord-028721-x6f26ahr 1698 26 is be VBZ cord-028721-x6f26ahr 1698 27 onset onset NN cord-028721-x6f26ahr 1698 28 of of IN cord-028721-x6f26ahr 1698 29 secondary secondary JJ cord-028721-x6f26ahr 1698 30 testicular testicular JJ cord-028721-x6f26ahr 1698 31 atrophy atrophy NN cord-028721-x6f26ahr 1698 32 and and CC cord-028721-x6f26ahr 1698 33 gynecomastia gynecomastia NN cord-028721-x6f26ahr 1698 34 . . . cord-028721-x6f26ahr 1699 1 Testosterone testosterone NN cord-028721-x6f26ahr 1699 2 levels level NNS cord-028721-x6f26ahr 1699 3 are be VBP cord-028721-x6f26ahr 1699 4 decreased decrease VBN cord-028721-x6f26ahr 1699 5 in in IN cord-028721-x6f26ahr 1699 6 some some DT cord-028721-x6f26ahr 1699 7 cases case NNS cord-028721-x6f26ahr 1699 8 . . . cord-028721-x6f26ahr 1700 1 The the DT cord-028721-x6f26ahr 1700 2 disease disease NN cord-028721-x6f26ahr 1700 3 results result VBZ cord-028721-x6f26ahr 1700 4 from from IN cord-028721-x6f26ahr 1700 5 mutations mutation NNS cord-028721-x6f26ahr 1700 6 in in IN cord-028721-x6f26ahr 1700 7 the the DT cord-028721-x6f26ahr 1700 8 fi fi NNP cord-028721-x6f26ahr 1700 9 rst rst NN cord-028721-x6f26ahr 1700 10 exon exon NN cord-028721-x6f26ahr 1700 11 of of IN cord-028721-x6f26ahr 1700 12 the the DT cord-028721-x6f26ahr 1700 13 androgen androgen NN cord-028721-x6f26ahr 1700 14 receptor receptor NN cord-028721-x6f26ahr 1700 15 ( ( -LRB- cord-028721-x6f26ahr 1700 16 AR AR NNP cord-028721-x6f26ahr 1700 17 ) ) -RRB- cord-028721-x6f26ahr 1700 18 gene gene NN cord-028721-x6f26ahr 1700 19 . . . cord-028721-x6f26ahr 1701 1 773 773 CD cord-028721-x6f26ahr 1702 1 The the DT cord-028721-x6f26ahr 1702 2 SMBA SMBA NNP cord-028721-x6f26ahr 1702 3 gene gene NN cord-028721-x6f26ahr 1702 4 , , , cord-028721-x6f26ahr 1702 5 located locate VBN cord-028721-x6f26ahr 1702 6 on on IN cord-028721-x6f26ahr 1702 7 Xq11 Xq11 NNP cord-028721-x6f26ahr 1702 8 - - HYPH cord-028721-x6f26ahr 1702 9 12 12 CD cord-028721-x6f26ahr 1702 10 , , , cord-028721-x6f26ahr 1702 11 has have VBZ cord-028721-x6f26ahr 1702 12 expansion expansion NN cord-028721-x6f26ahr 1702 13 of of IN cord-028721-x6f26ahr 1702 14 a a DT cord-028721-x6f26ahr 1702 15 repetitive repetitive JJ cord-028721-x6f26ahr 1702 16 CAG CAG NNP cord-028721-x6f26ahr 1702 17 sequence sequence NN cord-028721-x6f26ahr 1702 18 in in IN cord-028721-x6f26ahr 1702 19 exon exon NN cord-028721-x6f26ahr 1702 20 A. a. NN cord-028721-x6f26ahr 1703 1 The the DT cord-028721-x6f26ahr 1703 2 number number NN cord-028721-x6f26ahr 1703 3 of of IN cord-028721-x6f26ahr 1703 4 CAG CAG NNP cord-028721-x6f26ahr 1703 5 repeats repeat VBZ cord-028721-x6f26ahr 1703 6 is be VBZ cord-028721-x6f26ahr 1703 7 21 21 CD cord-028721-x6f26ahr 1704 1 ( ( -LRB- cord-028721-x6f26ahr 1704 2 range range NN cord-028721-x6f26ahr 1704 3 , , , cord-028721-x6f26ahr 1704 4 17 17 CD cord-028721-x6f26ahr 1704 5 - - SYM cord-028721-x6f26ahr 1704 6 26 26 CD cord-028721-x6f26ahr 1704 7 ) ) -RRB- cord-028721-x6f26ahr 1704 8 in in IN cord-028721-x6f26ahr 1704 9 control control NN cord-028721-x6f26ahr 1704 10 men man NNS cord-028721-x6f26ahr 1704 11 and and CC cord-028721-x6f26ahr 1704 12 more more JJR cord-028721-x6f26ahr 1704 13 than than IN cord-028721-x6f26ahr 1704 14 40 40 CD cord-028721-x6f26ahr 1704 15 in in IN cord-028721-x6f26ahr 1704 16 men man NNS cord-028721-x6f26ahr 1704 17 with with IN cord-028721-x6f26ahr 1704 18 Kennedy Kennedy NNP cord-028721-x6f26ahr 1704 19 's 's POS cord-028721-x6f26ahr 1704 20 disease disease NN cord-028721-x6f26ahr 1704 21 . . . cord-028721-x6f26ahr 1705 1 768 768 CD cord-028721-x6f26ahr 1705 2 , , , cord-028721-x6f26ahr 1705 3 [ [ -LRB- cord-028721-x6f26ahr 1705 4 774 774 CD cord-028721-x6f26ahr 1705 5 ] ] -RRB- cord-028721-x6f26ahr 1705 6 [ [ -LRB- cord-028721-x6f26ahr 1705 7 775 775 CD cord-028721-x6f26ahr 1705 8 ] ] -RRB- cord-028721-x6f26ahr 1705 9 [ [ -LRB- cord-028721-x6f26ahr 1705 10 776 776 CD cord-028721-x6f26ahr 1705 11 ] ] -RRB- cord-028721-x6f26ahr 1705 12 [ [ -LRB- cord-028721-x6f26ahr 1705 13 777 777 CD cord-028721-x6f26ahr 1705 14 ] ] -RRB- cord-028721-x6f26ahr 1705 15 _SP cord-028721-x6f26ahr 1706 1 This this DT cord-028721-x6f26ahr 1706 2 disorder disorder NN cord-028721-x6f26ahr 1706 3 is be VBZ cord-028721-x6f26ahr 1706 4 a a DT cord-028721-x6f26ahr 1706 5 variant variant NN cord-028721-x6f26ahr 1706 6 of of IN cord-028721-x6f26ahr 1706 7 male male JJ cord-028721-x6f26ahr 1706 8 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1706 9 caused cause VBN cord-028721-x6f26ahr 1706 10 by by IN cord-028721-x6f26ahr 1706 11 a a DT cord-028721-x6f26ahr 1706 12 lack lack NN cord-028721-x6f26ahr 1706 13 of of IN cord-028721-x6f26ahr 1706 14 the the DT cord-028721-x6f26ahr 1706 15 enzyme enzyme NN cord-028721-x6f26ahr 1706 16 5α 5α CD cord-028721-x6f26ahr 1706 17 - - HYPH cord-028721-x6f26ahr 1706 18 reductase reductase NN cord-028721-x6f26ahr 1706 19 with with IN cord-028721-x6f26ahr 1706 20 failure failure NN cord-028721-x6f26ahr 1706 21 of of IN cord-028721-x6f26ahr 1706 22 conversion conversion NN cord-028721-x6f26ahr 1706 23 of of IN cord-028721-x6f26ahr 1706 24 testosterone testosterone NN cord-028721-x6f26ahr 1706 25 to to IN cord-028721-x6f26ahr 1706 26 dihydrotestosterone dihydrotestosterone NN cord-028721-x6f26ahr 1706 27 . . . cord-028721-x6f26ahr 1707 1 778 778 CD cord-028721-x6f26ahr 1708 1 In in IN cord-028721-x6f26ahr 1708 2 patients patient NNS cord-028721-x6f26ahr 1708 3 with with IN cord-028721-x6f26ahr 1708 4 the the DT cord-028721-x6f26ahr 1708 5 46XY 46xy CD cord-028721-x6f26ahr 1708 6 karyotype karyotype NN cord-028721-x6f26ahr 1708 7 there there EX cord-028721-x6f26ahr 1708 8 are be VBP cord-028721-x6f26ahr 1708 9 two two CD cord-028721-x6f26ahr 1708 10 isoenzymes isoenzyme NNS cord-028721-x6f26ahr 1708 11 : : : cord-028721-x6f26ahr 1708 12 isoenzyme isoenzyme NNP cord-028721-x6f26ahr 1708 13 1 1 CD cord-028721-x6f26ahr 1708 14 is be VBZ cord-028721-x6f26ahr 1708 15 encoded encode VBN cord-028721-x6f26ahr 1708 16 by by IN cord-028721-x6f26ahr 1708 17 the the DT cord-028721-x6f26ahr 1708 18 gene gene NN cord-028721-x6f26ahr 1708 19 SRD5A srd5a NN cord-028721-x6f26ahr 1708 20 , , , cord-028721-x6f26ahr 1708 21 located locate VBN cord-028721-x6f26ahr 1708 22 on on IN cord-028721-x6f26ahr 1708 23 5p15 5p15 CD cord-028721-x6f26ahr 1708 24 , , , cord-028721-x6f26ahr 1708 25 and and CC cord-028721-x6f26ahr 1708 26 isoenzyme isoenzyme NNS cord-028721-x6f26ahr 1708 27 2 2 CD cord-028721-x6f26ahr 1708 28 is be VBZ cord-028721-x6f26ahr 1708 29 encoded encode VBN cord-028721-x6f26ahr 1708 30 by by IN cord-028721-x6f26ahr 1708 31 the the DT cord-028721-x6f26ahr 1708 32 gene gene NN cord-028721-x6f26ahr 1708 33 SRD5A2 SRD5A2 NNP cord-028721-x6f26ahr 1708 34 on on IN cord-028721-x6f26ahr 1708 35 2p23 2p23 CD cord-028721-x6f26ahr 1708 36 . . . cord-028721-x6f26ahr 1709 1 Most most RBS cord-028721-x6f26ahr 1709 2 reported report VBN cord-028721-x6f26ahr 1709 3 cases case NNS cord-028721-x6f26ahr 1709 4 result result VBP cord-028721-x6f26ahr 1709 5 from from IN cord-028721-x6f26ahr 1709 6 defects defect NNS cord-028721-x6f26ahr 1709 7 in in IN cord-028721-x6f26ahr 1709 8 SRD5A2 SRD5A2 NNP cord-028721-x6f26ahr 1709 9 . . . cord-028721-x6f26ahr 1710 1 779 779 CD cord-028721-x6f26ahr 1710 2 Many many JJ cord-028721-x6f26ahr 1710 3 mutations mutation NNS cord-028721-x6f26ahr 1710 4 in in IN cord-028721-x6f26ahr 1710 5 different different JJ cord-028721-x6f26ahr 1710 6 exons exon NNS cord-028721-x6f26ahr 1710 7 have have VBP cord-028721-x6f26ahr 1710 8 been be VBN cord-028721-x6f26ahr 1710 9 reported report VBN cord-028721-x6f26ahr 1710 10 . . . cord-028721-x6f26ahr 1711 1 [ [ -LRB- cord-028721-x6f26ahr 1711 2 780 780 CD cord-028721-x6f26ahr 1711 3 ] ] -RRB- cord-028721-x6f26ahr 1711 4 [ [ -LRB- cord-028721-x6f26ahr 1711 5 781 781 CD cord-028721-x6f26ahr 1711 6 ] ] -RRB- cord-028721-x6f26ahr 1711 7 [ [ -LRB- cord-028721-x6f26ahr 1711 8 782 782 CD cord-028721-x6f26ahr 1711 9 ] ] -RRB- cord-028721-x6f26ahr 1712 1 [ [ -LRB- cord-028721-x6f26ahr 1712 2 783 783 CD cord-028721-x6f26ahr 1712 3 ] ] -RRB- cord-028721-x6f26ahr 1712 4 [ [ -LRB- cord-028721-x6f26ahr 1712 5 784 784 CD cord-028721-x6f26ahr 1712 6 ] ] -RRB- cord-028721-x6f26ahr 1713 1 During during IN cord-028721-x6f26ahr 1713 2 childhood childhood NN cord-028721-x6f26ahr 1713 3 , , , cord-028721-x6f26ahr 1713 4 patients patient NNS cord-028721-x6f26ahr 1713 5 have have VBP cord-028721-x6f26ahr 1713 6 a a DT cord-028721-x6f26ahr 1713 7 clitoriform clitoriform NN cord-028721-x6f26ahr 1713 8 penis penis NN cord-028721-x6f26ahr 1713 9 , , , cord-028721-x6f26ahr 1713 10 bifi bifi NN cord-028721-x6f26ahr 1713 11 d d NN cord-028721-x6f26ahr 1713 12 scrotum scrotum NN cord-028721-x6f26ahr 1713 13 , , , cord-028721-x6f26ahr 1713 14 urogenital urogenital JJ cord-028721-x6f26ahr 1713 15 sinus sinus NN cord-028721-x6f26ahr 1713 16 , , , cord-028721-x6f26ahr 1713 17 and and CC cord-028721-x6f26ahr 1713 18 testes testis NNS cord-028721-x6f26ahr 1713 19 in in IN cord-028721-x6f26ahr 1713 20 the the DT cord-028721-x6f26ahr 1713 21 inguinal inguinal JJ cord-028721-x6f26ahr 1713 22 canal canal NNP cord-028721-x6f26ahr 1713 23 or or CC cord-028721-x6f26ahr 1713 24 labioscrotal labioscrotal NNP cord-028721-x6f26ahr 1713 25 folds fold VBZ cord-028721-x6f26ahr 1714 1 ( ( -LRB- cord-028721-x6f26ahr 1714 2 Fig Fig NNP cord-028721-x6f26ahr 1714 3 . . . cord-028721-x6f26ahr 1714 4 12 12 CD cord-028721-x6f26ahr 1714 5 - - SYM cord-028721-x6f26ahr 1714 6 80 80 CD cord-028721-x6f26ahr 1714 7 ) ) -RRB- cord-028721-x6f26ahr 1714 8 . . . cord-028721-x6f26ahr 1715 1 Müllerian müllerian JJ cord-028721-x6f26ahr 1715 2 derivatives derivative NNS cord-028721-x6f26ahr 1715 3 are be VBP cord-028721-x6f26ahr 1715 4 absent absent JJ cord-028721-x6f26ahr 1715 5 . . . cord-028721-x6f26ahr 1716 1 At at IN cord-028721-x6f26ahr 1716 2 puberty puberty NN cord-028721-x6f26ahr 1716 3 they -PRON- PRP cord-028721-x6f26ahr 1716 4 acquire acquire VBP cord-028721-x6f26ahr 1716 5 the the DT cord-028721-x6f26ahr 1716 6 male male JJ cord-028721-x6f26ahr 1716 7 phenotype phenotype NN cord-028721-x6f26ahr 1716 8 , , , cord-028721-x6f26ahr 1716 9 with with IN cord-028721-x6f26ahr 1716 10 development development NN cord-028721-x6f26ahr 1716 11 of of IN cord-028721-x6f26ahr 1716 12 the the DT cord-028721-x6f26ahr 1716 13 penis penis NN cord-028721-x6f26ahr 1716 14 and and CC cord-028721-x6f26ahr 1716 15 scrotum scrotum NN cord-028721-x6f26ahr 1716 16 . . . cord-028721-x6f26ahr 1717 1 Adults adult NNS cord-028721-x6f26ahr 1717 2 have have VBP cord-028721-x6f26ahr 1717 3 erections erection NNS cord-028721-x6f26ahr 1717 4 , , , cord-028721-x6f26ahr 1717 5 ejaculations ejaculation NNS cord-028721-x6f26ahr 1717 6 , , , cord-028721-x6f26ahr 1717 7 and and CC cord-028721-x6f26ahr 1717 8 normal normal JJ cord-028721-x6f26ahr 1717 9 libido libido NN cord-028721-x6f26ahr 1717 10 , , , cord-028721-x6f26ahr 1717 11 scant scant JJ cord-028721-x6f26ahr 1717 12 body body NN cord-028721-x6f26ahr 1717 13 hair hair NN cord-028721-x6f26ahr 1717 14 and and CC cord-028721-x6f26ahr 1717 15 a a DT cord-028721-x6f26ahr 1717 16 thin thin JJ cord-028721-x6f26ahr 1717 17 beard beard NN cord-028721-x6f26ahr 1717 18 , , , cord-028721-x6f26ahr 1717 19 a a DT cord-028721-x6f26ahr 1717 20 very very RB cord-028721-x6f26ahr 1717 21 small small JJ cord-028721-x6f26ahr 1717 22 prostate prostate NN cord-028721-x6f26ahr 1717 23 , , , cord-028721-x6f26ahr 1717 24 and and CC cord-028721-x6f26ahr 1717 25 lack lack NN cord-028721-x6f26ahr 1717 26 of of IN cord-028721-x6f26ahr 1717 27 temporal temporal JJ cord-028721-x6f26ahr 1717 28 hairline hairline NN cord-028721-x6f26ahr 1717 29 recession recession NN cord-028721-x6f26ahr 1717 30 ( ( -LRB- cord-028721-x6f26ahr 1717 31 male male JJ cord-028721-x6f26ahr 1717 32 pattern pattern NN cord-028721-x6f26ahr 1717 33 baldness baldness NN cord-028721-x6f26ahr 1717 34 ) ) -RRB- cord-028721-x6f26ahr 1717 35 . . . cord-028721-x6f26ahr 1718 1 Serum serum NN cord-028721-x6f26ahr 1718 2 levels level NNS cord-028721-x6f26ahr 1718 3 of of IN cord-028721-x6f26ahr 1718 4 FSH fsh NN cord-028721-x6f26ahr 1718 5 , , , cord-028721-x6f26ahr 1718 6 LH LH NNP cord-028721-x6f26ahr 1718 7 , , , cord-028721-x6f26ahr 1718 8 and and CC cord-028721-x6f26ahr 1718 9 testosterone testosterone NN cord-028721-x6f26ahr 1718 10 are be VBP cord-028721-x6f26ahr 1718 11 increased increase VBN cord-028721-x6f26ahr 1718 12 , , , cord-028721-x6f26ahr 1718 13 but but CC cord-028721-x6f26ahr 1718 14 dihydrotestosterone dihydrotestosterone NN cord-028721-x6f26ahr 1718 15 is be VBZ cord-028721-x6f26ahr 1718 16 decreased decrease VBN cord-028721-x6f26ahr 1718 17 . . . cord-028721-x6f26ahr 1719 1 785 785 CD cord-028721-x6f26ahr 1719 2 , , , cord-028721-x6f26ahr 1719 3 786 786 CD cord-028721-x6f26ahr 1720 1 The the DT cord-028721-x6f26ahr 1720 2 disorder disorder NN cord-028721-x6f26ahr 1720 3 is be VBZ cord-028721-x6f26ahr 1720 4 autosomal autosomal JJ cord-028721-x6f26ahr 1720 5 recessive recessive JJ cord-028721-x6f26ahr 1720 6 and and CC cord-028721-x6f26ahr 1720 7 has have VBZ cord-028721-x6f26ahr 1720 8 been be VBN cord-028721-x6f26ahr 1720 9 observed observe VBN cord-028721-x6f26ahr 1720 10 in in IN cord-028721-x6f26ahr 1720 11 many many JJ cord-028721-x6f26ahr 1720 12 consanguineous consanguineous JJ cord-028721-x6f26ahr 1720 13 families family NNS cord-028721-x6f26ahr 1720 14 from from IN cord-028721-x6f26ahr 1720 15 the the DT cord-028721-x6f26ahr 1720 16 Dominican Dominican NNP cord-028721-x6f26ahr 1720 17 Republic Republic NNP cord-028721-x6f26ahr 1720 18 . . . cord-028721-x6f26ahr 1721 1 787 787 CD cord-028721-x6f26ahr 1722 1 This this DT cord-028721-x6f26ahr 1722 2 group group NN cord-028721-x6f26ahr 1722 3 of of IN cord-028721-x6f26ahr 1722 4 male male JJ cord-028721-x6f26ahr 1722 5 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 1722 6 is be VBZ cord-028721-x6f26ahr 1722 7 characterized characterize VBN cord-028721-x6f26ahr 1722 8 by by IN cord-028721-x6f26ahr 1722 9 the the DT cord-028721-x6f26ahr 1722 10 presence presence NN cord-028721-x6f26ahr 1722 11 of of IN cord-028721-x6f26ahr 1722 12 müllerian müllerian JJ cord-028721-x6f26ahr 1722 13 derivatives derivative NNS cord-028721-x6f26ahr 1722 14 and and CC cord-028721-x6f26ahr 1722 15 unilateral unilateral JJ cord-028721-x6f26ahr 1722 16 or or CC cord-028721-x6f26ahr 1722 17 bilateral bilateral JJ cord-028721-x6f26ahr 1722 18 testicular testicular NN cord-028721-x6f26ahr 1722 19 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1722 20 . . . cord-028721-x6f26ahr 1723 1 These these DT cord-028721-x6f26ahr 1723 2 two two CD cord-028721-x6f26ahr 1723 3 features feature NNS cord-028721-x6f26ahr 1723 4 depend depend VBP cord-028721-x6f26ahr 1723 5 on on IN cord-028721-x6f26ahr 1723 6 anti anti JJ cord-028721-x6f26ahr 1723 7 - - JJ cord-028721-x6f26ahr 1723 8 müllerian müllerian JJ cord-028721-x6f26ahr 1723 9 hormone hormone NN cord-028721-x6f26ahr 1723 10 gene gene NN cord-028721-x6f26ahr 1723 11 mutations mutation NNS cord-028721-x6f26ahr 1723 12 and and CC cord-028721-x6f26ahr 1723 13 end end NN cord-028721-x6f26ahr 1723 14 - - HYPH cord-028721-x6f26ahr 1723 15 organ organ NN cord-028721-x6f26ahr 1723 16 insensitivity insensitivity NN cord-028721-x6f26ahr 1723 17 . . . cord-028721-x6f26ahr 1724 1 [ [ -LRB- cord-028721-x6f26ahr 1724 2 788 788 CD cord-028721-x6f26ahr 1724 3 ] ] -RRB- cord-028721-x6f26ahr 1724 4 [ [ -LRB- cord-028721-x6f26ahr 1724 5 789 789 CD cord-028721-x6f26ahr 1724 6 ] ] -RRB- cord-028721-x6f26ahr 1724 7 [ [ -LRB- cord-028721-x6f26ahr 1724 8 790 790 CD cord-028721-x6f26ahr 1724 9 ] ] -RRB- cord-028721-x6f26ahr 1725 1 [ [ -LRB- cord-028721-x6f26ahr 1725 2 791 791 CD cord-028721-x6f26ahr 1725 3 ] ] -RRB- cord-028721-x6f26ahr 1726 1 In in IN cord-028721-x6f26ahr 1726 2 normal normal JJ cord-028721-x6f26ahr 1726 3 development development NN cord-028721-x6f26ahr 1726 4 , , , cord-028721-x6f26ahr 1726 5 anti anti JJ cord-028721-x6f26ahr 1726 6 - - JJ cord-028721-x6f26ahr 1726 7 müllerian müllerian JJ cord-028721-x6f26ahr 1726 8 hormone hormone NN cord-028721-x6f26ahr 1726 9 is be VBZ cord-028721-x6f26ahr 1726 10 responsible responsible JJ cord-028721-x6f26ahr 1726 11 for for IN cord-028721-x6f26ahr 1726 12 inhibition inhibition NN cord-028721-x6f26ahr 1726 13 of of IN cord-028721-x6f26ahr 1726 14 the the DT cord-028721-x6f26ahr 1726 15 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 1726 16 müllerian müllerian JJ cord-028721-x6f26ahr 1726 17 ducts duct NNS cord-028721-x6f26ahr 1726 18 and and CC cord-028721-x6f26ahr 1726 19 collagenization collagenization NN cord-028721-x6f26ahr 1726 20 of of IN cord-028721-x6f26ahr 1726 21 the the DT cord-028721-x6f26ahr 1726 22 tunica tunica NNP cord-028721-x6f26ahr 1726 23 albuginea albuginea NNP cord-028721-x6f26ahr 1726 24 . . . cord-028721-x6f26ahr 1727 1 Patients patient NNS cord-028721-x6f26ahr 1727 2 with with IN cord-028721-x6f26ahr 1727 3 defi defi NNP cord-028721-x6f26ahr 1727 4 cient cient NN cord-028721-x6f26ahr 1727 5 secretion secretion NN cord-028721-x6f26ahr 1727 6 of of IN cord-028721-x6f26ahr 1727 7 this this DT cord-028721-x6f26ahr 1727 8 hormone hormone NN cord-028721-x6f26ahr 1727 9 may may MD cord-028721-x6f26ahr 1727 10 also also RB cord-028721-x6f26ahr 1727 11 have have VB cord-028721-x6f26ahr 1727 12 androgen androgen NN cord-028721-x6f26ahr 1727 13 defi defi NNP cord-028721-x6f26ahr 1727 14 ciency ciency NNP cord-028721-x6f26ahr 1727 15 . . . cord-028721-x6f26ahr 1728 1 Three three CD cord-028721-x6f26ahr 1728 2 variants variant NNS cord-028721-x6f26ahr 1728 3 of of IN cord-028721-x6f26ahr 1728 4 defective defective JJ cord-028721-x6f26ahr 1728 5 müllerian müllerian JJ cord-028721-x6f26ahr 1728 6 duct duct NN cord-028721-x6f26ahr 1728 7 regression regression NN cord-028721-x6f26ahr 1728 8 have have VBP cord-028721-x6f26ahr 1728 9 been be VBN cord-028721-x6f26ahr 1728 10 reported report VBN cord-028721-x6f26ahr 1728 11 : : : cord-028721-x6f26ahr 1728 12 mixed mix VBN cord-028721-x6f26ahr 1728 13 gonadal gonadal JJ cord-028721-x6f26ahr 1728 14 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1728 15 , , , cord-028721-x6f26ahr 1728 16 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1728 17 male male JJ cord-028721-x6f26ahr 1728 18 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1728 19 , , , cord-028721-x6f26ahr 1728 20 and and CC cord-028721-x6f26ahr 1728 21 persistent persistent JJ cord-028721-x6f26ahr 1728 22 müllerian müllerian JJ cord-028721-x6f26ahr 1728 23 duct duct NN cord-028721-x6f26ahr 1728 24 syndrome syndrome NN cord-028721-x6f26ahr 1728 25 . . . cord-028721-x6f26ahr 1729 1 Mixed mixed JJ cord-028721-x6f26ahr 1729 2 gonadal gonadal NN cord-028721-x6f26ahr 1729 3 dysgenesis dysgenesis FW cord-028721-x6f26ahr 1729 4 ( ( -LRB- cord-028721-x6f26ahr 1729 5 asymmetric asymmetric JJ cord-028721-x6f26ahr 1729 6 gonadal gonadal JJ cord-028721-x6f26ahr 1729 7 differentiation differentiation NN cord-028721-x6f26ahr 1729 8 ) ) -RRB- cord-028721-x6f26ahr 1729 9 is be VBZ cord-028721-x6f26ahr 1729 10 characterized characterize VBN cord-028721-x6f26ahr 1729 11 by by IN cord-028721-x6f26ahr 1729 12 the the DT cord-028721-x6f26ahr 1729 13 presence presence NN cord-028721-x6f26ahr 1729 14 of of IN cord-028721-x6f26ahr 1729 15 a a DT cord-028721-x6f26ahr 1729 16 testis testis NN cord-028721-x6f26ahr 1729 17 on on IN cord-028721-x6f26ahr 1729 18 one one CD cord-028721-x6f26ahr 1729 19 side side NN cord-028721-x6f26ahr 1729 20 of of IN cord-028721-x6f26ahr 1729 21 the the DT cord-028721-x6f26ahr 1729 22 body body NN cord-028721-x6f26ahr 1729 23 and and CC cord-028721-x6f26ahr 1729 24 a a DT cord-028721-x6f26ahr 1729 25 streak streak NN cord-028721-x6f26ahr 1729 26 gonad gonad NN cord-028721-x6f26ahr 1729 27 on on IN cord-028721-x6f26ahr 1729 28 the the DT cord-028721-x6f26ahr 1729 29 other other JJ cord-028721-x6f26ahr 1729 30 . . . cord-028721-x6f26ahr 1730 1 792 792 CD cord-028721-x6f26ahr 1731 1 If if IN cord-028721-x6f26ahr 1731 2 the the DT cord-028721-x6f26ahr 1731 3 gonads gonad NNS cord-028721-x6f26ahr 1731 4 are be VBP cord-028721-x6f26ahr 1731 5 intra intra JJ cord-028721-x6f26ahr 1731 6 - - JJ cord-028721-x6f26ahr 1731 7 abdominal abdominal JJ cord-028721-x6f26ahr 1731 8 , , , cord-028721-x6f26ahr 1731 9 the the DT cord-028721-x6f26ahr 1731 10 labioscrotal labioscrotal JJ cord-028721-x6f26ahr 1731 11 folds fold NNS cord-028721-x6f26ahr 1731 12 may may MD cord-028721-x6f26ahr 1731 13 appear appear VB cord-028721-x6f26ahr 1731 14 as as IN cord-028721-x6f26ahr 1731 15 either either DT cord-028721-x6f26ahr 1731 16 normal normal JJ cord-028721-x6f26ahr 1731 17 labia labium NNS cord-028721-x6f26ahr 1731 18 or or CC cord-028721-x6f26ahr 1731 19 empty empty JJ cord-028721-x6f26ahr 1731 20 scrotal scrotal JJ cord-028721-x6f26ahr 1731 21 sacs sac NNS cord-028721-x6f26ahr 1732 1 ( ( -LRB- cord-028721-x6f26ahr 1732 2 Fig Fig NNP cord-028721-x6f26ahr 1732 3 . . . cord-028721-x6f26ahr 1732 4 12 12 CD cord-028721-x6f26ahr 1732 5 - - SYM cord-028721-x6f26ahr 1732 6 81 81 CD cord-028721-x6f26ahr 1732 7 ) ) -RRB- cord-028721-x6f26ahr 1732 8 . . . cord-028721-x6f26ahr 1733 1 In in IN cord-028721-x6f26ahr 1733 2 the the DT cord-028721-x6f26ahr 1733 3 former former JJ cord-028721-x6f26ahr 1733 4 , , , cord-028721-x6f26ahr 1733 5 the the DT cord-028721-x6f26ahr 1733 6 syndrome syndrome NN cord-028721-x6f26ahr 1733 7 can can MD cord-028721-x6f26ahr 1733 8 not not RB cord-028721-x6f26ahr 1733 9 be be VB cord-028721-x6f26ahr 1733 10 recognized recognize VBN cord-028721-x6f26ahr 1733 11 in in IN cord-028721-x6f26ahr 1733 12 the the DT cord-028721-x6f26ahr 1733 13 newborn newborn NN cord-028721-x6f26ahr 1733 14 unless unless IN cord-028721-x6f26ahr 1733 15 a a DT cord-028721-x6f26ahr 1733 16 peniform peniform NN cord-028721-x6f26ahr 1733 17 clitoris clitoris NN cord-028721-x6f26ahr 1733 18 is be VBZ cord-028721-x6f26ahr 1733 19 present present JJ cord-028721-x6f26ahr 1733 20 . . . cord-028721-x6f26ahr 1734 1 If if IN cord-028721-x6f26ahr 1734 2 the the DT cord-028721-x6f26ahr 1734 3 gonad gonad NN cord-028721-x6f26ahr 1734 4 is be VBZ cord-028721-x6f26ahr 1734 5 descended descend VBN cord-028721-x6f26ahr 1734 6 , , , cord-028721-x6f26ahr 1734 7 it -PRON- PRP cord-028721-x6f26ahr 1734 8 is be VBZ cord-028721-x6f26ahr 1734 9 usually usually RB cord-028721-x6f26ahr 1734 10 a a DT cord-028721-x6f26ahr 1734 11 testis testis NN cord-028721-x6f26ahr 1734 12 . . . cord-028721-x6f26ahr 1735 1 Müllerian müllerian JJ cord-028721-x6f26ahr 1735 2 derivatives derivative NNS cord-028721-x6f26ahr 1735 3 such such JJ cord-028721-x6f26ahr 1735 4 as as IN cord-028721-x6f26ahr 1735 5 fallopian fallopian JJ cord-028721-x6f26ahr 1735 6 tubes tube NNS cord-028721-x6f26ahr 1735 7 are be VBP cord-028721-x6f26ahr 1735 8 usually usually RB cord-028721-x6f26ahr 1735 9 associated associate VBN cord-028721-x6f26ahr 1735 10 with with IN cord-028721-x6f26ahr 1735 11 streak streak NN cord-028721-x6f26ahr 1735 12 gonad gonad NN cord-028721-x6f26ahr 1735 13 ( ( -LRB- cord-028721-x6f26ahr 1735 14 95 95 CD cord-028721-x6f26ahr 1735 15 % % NN cord-028721-x6f26ahr 1735 16 of of IN cord-028721-x6f26ahr 1735 17 cases case NNS cord-028721-x6f26ahr 1735 18 ) ) -RRB- cord-028721-x6f26ahr 1735 19 , , , cord-028721-x6f26ahr 1735 20 but but CC cord-028721-x6f26ahr 1735 21 may may MD cord-028721-x6f26ahr 1735 22 also also RB cord-028721-x6f26ahr 1735 23 be be VB cord-028721-x6f26ahr 1735 24 associated associate VBN cord-028721-x6f26ahr 1735 25 with with IN cord-028721-x6f26ahr 1735 26 testicular testicular JJ cord-028721-x6f26ahr 1735 27 tissue tissue NN cord-028721-x6f26ahr 1735 28 ( ( -LRB- cord-028721-x6f26ahr 1735 29 74 74 CD cord-028721-x6f26ahr 1735 30 % % NN cord-028721-x6f26ahr 1735 31 ) ) -RRB- cord-028721-x6f26ahr 1735 32 . . . cord-028721-x6f26ahr 1736 1 Ipsilateral Ipsilateral NNP cord-028721-x6f26ahr 1736 2 to to IN cord-028721-x6f26ahr 1736 3 the the DT cord-028721-x6f26ahr 1736 4 testis testis NN cord-028721-x6f26ahr 1736 5 there there EX cord-028721-x6f26ahr 1736 6 is be VBZ cord-028721-x6f26ahr 1736 7 one one CD cord-028721-x6f26ahr 1736 8 epididymis epididymis NN cord-028721-x6f26ahr 1736 9 and and CC cord-028721-x6f26ahr 1736 10 one one CD cord-028721-x6f26ahr 1736 11 vas vas NN cord-028721-x6f26ahr 1736 12 deferens deferen NNS cord-028721-x6f26ahr 1736 13 . . . cord-028721-x6f26ahr 1737 1 On on IN cord-028721-x6f26ahr 1737 2 the the DT cord-028721-x6f26ahr 1737 3 contralateral contralateral JJ cord-028721-x6f26ahr 1737 4 side side NN cord-028721-x6f26ahr 1737 5 , , , cord-028721-x6f26ahr 1737 6 no no DT cord-028721-x6f26ahr 1737 7 gonad gonad NN cord-028721-x6f26ahr 1737 8 or or CC cord-028721-x6f26ahr 1737 9 a a DT cord-028721-x6f26ahr 1737 10 streak streak NN cord-028721-x6f26ahr 1737 11 gonad gonad NN cord-028721-x6f26ahr 1737 12 and and CC cord-028721-x6f26ahr 1737 13 a a DT cord-028721-x6f26ahr 1737 14 fallopian fallopian JJ cord-028721-x6f26ahr 1737 15 tube tube NN cord-028721-x6f26ahr 1737 16 are be VBP cord-028721-x6f26ahr 1737 17 present present JJ cord-028721-x6f26ahr 1737 18 . . . cord-028721-x6f26ahr 1738 1 A a DT cord-028721-x6f26ahr 1738 2 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1738 3 uterus uterus NN cord-028721-x6f26ahr 1738 4 and and CC cord-028721-x6f26ahr 1738 5 a a DT cord-028721-x6f26ahr 1738 6 poorly poorly RB cord-028721-x6f26ahr 1738 7 developed develop VBN cord-028721-x6f26ahr 1738 8 vagina vagina NN cord-028721-x6f26ahr 1738 9 are be VBP cord-028721-x6f26ahr 1738 10 frequent frequent JJ cord-028721-x6f26ahr 1738 11 fi fi NN cord-028721-x6f26ahr 1738 12 ndings nding NNS cord-028721-x6f26ahr 1738 13 . . . cord-028721-x6f26ahr 1739 1 This this DT cord-028721-x6f26ahr 1739 2 syndrome syndrome NN cord-028721-x6f26ahr 1739 3 accounts account VBZ cord-028721-x6f26ahr 1739 4 for for IN cord-028721-x6f26ahr 1739 5 about about RB cord-028721-x6f26ahr 1739 6 15 15 CD cord-028721-x6f26ahr 1739 7 % % NN cord-028721-x6f26ahr 1739 8 of of IN cord-028721-x6f26ahr 1739 9 intersex intersex NN cord-028721-x6f26ahr 1739 10 conditions condition NNS cord-028721-x6f26ahr 1739 11 . . . cord-028721-x6f26ahr 1740 1 Some some DT cord-028721-x6f26ahr 1740 2 patients patient NNS cord-028721-x6f26ahr 1740 3 are be VBP cord-028721-x6f26ahr 1740 4 raised raise VBN cord-028721-x6f26ahr 1740 5 as as IN cord-028721-x6f26ahr 1740 6 males male NNS cord-028721-x6f26ahr 1740 7 , , , cord-028721-x6f26ahr 1740 8 although although IN cord-028721-x6f26ahr 1740 9 their -PRON- PRP$ cord-028721-x6f26ahr 1740 10 external external JJ cord-028721-x6f26ahr 1740 11 genitalia genitalia NNS cord-028721-x6f26ahr 1740 12 are be VBP cord-028721-x6f26ahr 1740 13 usually usually RB cord-028721-x6f26ahr 1740 14 ambiguous ambiguous JJ cord-028721-x6f26ahr 1740 15 as as IN cord-028721-x6f26ahr 1740 16 a a DT cord-028721-x6f26ahr 1740 17 result result NN cord-028721-x6f26ahr 1740 18 of of IN cord-028721-x6f26ahr 1740 19 fetal fetal JJ cord-028721-x6f26ahr 1740 20 virilization virilization NN cord-028721-x6f26ahr 1740 21 . . . cord-028721-x6f26ahr 1741 1 The the DT cord-028721-x6f26ahr 1741 2 penis penis NN cord-028721-x6f26ahr 1741 3 is be VBZ cord-028721-x6f26ahr 1741 4 clitoriform clitoriform NN cord-028721-x6f26ahr 1741 5 , , , cord-028721-x6f26ahr 1741 6 and and CC cord-028721-x6f26ahr 1741 7 the the DT cord-028721-x6f26ahr 1741 8 urethra urethra NN cord-028721-x6f26ahr 1741 9 opens open VBZ cord-028721-x6f26ahr 1741 10 in in IN cord-028721-x6f26ahr 1741 11 the the DT cord-028721-x6f26ahr 1741 12 perineum perineum NN cord-028721-x6f26ahr 1741 13 . . . cord-028721-x6f26ahr 1742 1 Most Most JJS cord-028721-x6f26ahr 1742 2 have have VBP cord-028721-x6f26ahr 1742 3 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1742 4 testes testis NNS cord-028721-x6f26ahr 1742 5 and and CC cord-028721-x6f26ahr 1742 6 are be VBP cord-028721-x6f26ahr 1742 7 raised raise VBN cord-028721-x6f26ahr 1742 8 as as IN cord-028721-x6f26ahr 1742 9 girls girl NNS cord-028721-x6f26ahr 1742 10 , , , cord-028721-x6f26ahr 1742 11 becoming become VBG cord-028721-x6f26ahr 1742 12 virilized virilize VBN cord-028721-x6f26ahr 1742 13 at at IN cord-028721-x6f26ahr 1742 14 puberty puberty NN cord-028721-x6f26ahr 1742 15 . . . cord-028721-x6f26ahr 1743 1 Infertility infertility NN cord-028721-x6f26ahr 1743 2 is be VBZ cord-028721-x6f26ahr 1743 3 a a DT cord-028721-x6f26ahr 1743 4 common common JJ cord-028721-x6f26ahr 1743 5 symptom symptom NN cord-028721-x6f26ahr 1743 6 . . . cord-028721-x6f26ahr 1744 1 793 793 CD cord-028721-x6f26ahr 1745 1 The the DT cord-028721-x6f26ahr 1745 2 etiology etiology NN cord-028721-x6f26ahr 1745 3 is be VBZ cord-028721-x6f26ahr 1745 4 heterogeneous heterogeneous JJ cord-028721-x6f26ahr 1745 5 : : : cord-028721-x6f26ahr 1745 6 794 794 CD cord-028721-x6f26ahr 1745 7 one one CD cord-028721-x6f26ahr 1745 8 - - HYPH cord-028721-x6f26ahr 1745 9 third third NN cord-028721-x6f26ahr 1745 10 of of IN cord-028721-x6f26ahr 1745 11 patients patient NNS cord-028721-x6f26ahr 1745 12 have have VBP cord-028721-x6f26ahr 1745 13 turnerian turnerian NN cord-028721-x6f26ahr 1745 14 features feature NNS cord-028721-x6f26ahr 1745 15 , , , cord-028721-x6f26ahr 1745 16 in in IN cord-028721-x6f26ahr 1745 17 accordance accordance NN cord-028721-x6f26ahr 1745 18 with with IN cord-028721-x6f26ahr 1745 19 the the DT cord-028721-x6f26ahr 1745 20 presence presence NN cord-028721-x6f26ahr 1745 21 of of IN cord-028721-x6f26ahr 1745 22 the the DT cord-028721-x6f26ahr 1745 23 45X0/46XY 45x0/46xy CD cord-028721-x6f26ahr 1745 24 karyotype karyotype NN cord-028721-x6f26ahr 1745 25 in in IN cord-028721-x6f26ahr 1745 26 more more JJR cord-028721-x6f26ahr 1745 27 than than IN cord-028721-x6f26ahr 1745 28 50 50 CD cord-028721-x6f26ahr 1745 29 % % NN cord-028721-x6f26ahr 1745 30 of of IN cord-028721-x6f26ahr 1745 31 patients patient NNS cord-028721-x6f26ahr 1745 32 . . . cord-028721-x6f26ahr 1746 1 Other other JJ cord-028721-x6f26ahr 1746 2 observed observed JJ cord-028721-x6f26ahr 1746 3 karyotypes karyotype NNS cord-028721-x6f26ahr 1746 4 are be VBP cord-028721-x6f26ahr 1746 5 46XY 46xy CD cord-028721-x6f26ahr 1746 6 and and CC cord-028721-x6f26ahr 1746 7 45X0/47XYY 45x0/47xyy CD cord-028721-x6f26ahr 1746 8 . . . cord-028721-x6f26ahr 1747 1 Approximately approximately RB cord-028721-x6f26ahr 1747 2 81 81 CD cord-028721-x6f26ahr 1747 3 % % NN cord-028721-x6f26ahr 1747 4 of of IN cord-028721-x6f26ahr 1747 5 patients patient NNS cord-028721-x6f26ahr 1747 6 have have VBP cord-028721-x6f26ahr 1747 7 one one CD cord-028721-x6f26ahr 1747 8 Y Y NNP cord-028721-x6f26ahr 1747 9 chromosome chromosome NN cord-028721-x6f26ahr 1747 10 . . . cord-028721-x6f26ahr 1748 1 Mutation mutation NN cord-028721-x6f26ahr 1748 2 in in IN cord-028721-x6f26ahr 1748 3 the the DT cord-028721-x6f26ahr 1748 4 SRY SRY NNP cord-028721-x6f26ahr 1748 5 gene gene NN cord-028721-x6f26ahr 1748 6 has have VBZ cord-028721-x6f26ahr 1748 7 not not RB cord-028721-x6f26ahr 1748 8 been be VBN cord-028721-x6f26ahr 1748 9 found find VBN cord-028721-x6f26ahr 1748 10 . . . cord-028721-x6f26ahr 1749 1 795 795 CD cord-028721-x6f26ahr 1750 1 The the DT cord-028721-x6f26ahr 1750 2 testes testis NNS cord-028721-x6f26ahr 1750 3 can can MD cord-028721-x6f26ahr 1750 4 show show VB cord-028721-x6f26ahr 1750 5 two two CD cord-028721-x6f26ahr 1750 6 different different JJ cord-028721-x6f26ahr 1750 7 patterns pattern NNS cord-028721-x6f26ahr 1750 8 : : : cord-028721-x6f26ahr 1750 9 testicular testicular JJ cord-028721-x6f26ahr 1750 10 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1750 11 and and CC cord-028721-x6f26ahr 1750 12 streak streak NN cord-028721-x6f26ahr 1750 13 testis testis NN cord-028721-x6f26ahr 1750 14 . . . cord-028721-x6f26ahr 1751 1 Testicular testicular NN cord-028721-x6f26ahr 1751 2 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1751 3 is be VBZ cord-028721-x6f26ahr 1751 4 characterized characterize VBN cord-028721-x6f26ahr 1751 5 by by IN cord-028721-x6f26ahr 1751 6 a a DT cord-028721-x6f26ahr 1751 7 tunica tunica NNP cord-028721-x6f26ahr 1751 8 albuginea albuginea NNP cord-028721-x6f26ahr 1751 9 that that WDT cord-028721-x6f26ahr 1751 10 varies vary VBZ cord-028721-x6f26ahr 1751 11 in in IN cord-028721-x6f26ahr 1751 12 width width NN cord-028721-x6f26ahr 1751 13 and and CC cord-028721-x6f26ahr 1751 14 is be VBZ cord-028721-x6f26ahr 1751 15 reminiscent reminiscent JJ cord-028721-x6f26ahr 1751 16 of of IN cord-028721-x6f26ahr 1751 17 ovarian ovarian JJ cord-028721-x6f26ahr 1751 18 stroma stroma NN cord-028721-x6f26ahr 1751 19 by by IN cord-028721-x6f26ahr 1751 20 the the DT cord-028721-x6f26ahr 1751 21 storiform storiform JJ cord-028721-x6f26ahr 1751 22 distribution distribution NN cord-028721-x6f26ahr 1751 23 of of IN cord-028721-x6f26ahr 1751 24 cells cell NNS cord-028721-x6f26ahr 1751 25 and and CC cord-028721-x6f26ahr 1751 26 fi fi NN cord-028721-x6f26ahr 1751 27 bers ber NNS cord-028721-x6f26ahr 1751 28 ; ; : cord-028721-x6f26ahr 1751 29 there there EX cord-028721-x6f26ahr 1751 30 are be VBP cord-028721-x6f26ahr 1751 31 also also RB cord-028721-x6f26ahr 1751 32 malformed malformed JJ cord-028721-x6f26ahr 1751 33 seminiferous seminiferous JJ cord-028721-x6f26ahr 1751 34 tubules tubule NNS cord-028721-x6f26ahr 1751 35 ( ( -LRB- cord-028721-x6f26ahr 1751 36 Fig Fig NNP cord-028721-x6f26ahr 1751 37 . . . cord-028721-x6f26ahr 1751 38 _SP cord-028721-x6f26ahr 1752 1 12 12 CD cord-028721-x6f26ahr 1752 2 - - SYM cord-028721-x6f26ahr 1752 3 82 82 CD cord-028721-x6f26ahr 1752 4 ) ) -RRB- cord-028721-x6f26ahr 1753 1 that that WDT cord-028721-x6f26ahr 1753 2 are be VBP cord-028721-x6f26ahr 1753 3 small small JJ cord-028721-x6f26ahr 1753 4 , , , cord-028721-x6f26ahr 1753 5 usually usually RB cord-028721-x6f26ahr 1753 6 lack lack VBP cord-028721-x6f26ahr 1753 7 lumina lumina NNP cord-028721-x6f26ahr 1753 8 , , , cord-028721-x6f26ahr 1753 9 and and CC cord-028721-x6f26ahr 1753 10 contain contain VBP cord-028721-x6f26ahr 1753 11 only only RB cord-028721-x6f26ahr 1753 12 immature immature JJ cord-028721-x6f26ahr 1753 13 Sertoli Sertoli NNP cord-028721-x6f26ahr 1753 14 cells cell NNS cord-028721-x6f26ahr 1753 15 . . . cord-028721-x6f26ahr 1754 1 In in IN cord-028721-x6f26ahr 1754 2 adults adult NNS cord-028721-x6f26ahr 1754 3 , , , cord-028721-x6f26ahr 1754 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1754 5 has have VBZ cord-028721-x6f26ahr 1754 6 been be VBN cord-028721-x6f26ahr 1754 7 observed observe VBN cord-028721-x6f26ahr 1754 8 occasionally occasionally RB cord-028721-x6f26ahr 1754 9 . . . cord-028721-x6f26ahr 1755 1 The the DT cord-028721-x6f26ahr 1755 2 testicular testicular JJ cord-028721-x6f26ahr 1755 3 interstitium interstitium NN cord-028721-x6f26ahr 1755 4 contains contain VBZ cord-028721-x6f26ahr 1755 5 increased increase VBN cord-028721-x6f26ahr 1755 6 numbers number NNS cord-028721-x6f26ahr 1755 7 of of IN cord-028721-x6f26ahr 1755 8 Leydig Leydig NNP cord-028721-x6f26ahr 1755 9 cells cell NNS cord-028721-x6f26ahr 1755 10 . . . cord-028721-x6f26ahr 1756 1 Streak streak NN cord-028721-x6f26ahr 1756 2 testes testis NNS cord-028721-x6f26ahr 1756 3 are be VBP cord-028721-x6f26ahr 1756 4 complex complex JJ cord-028721-x6f26ahr 1756 5 gonads gonad NNS cord-028721-x6f26ahr 1756 6 in in IN cord-028721-x6f26ahr 1756 7 which which WDT cord-028721-x6f26ahr 1756 8 testicular testicular NN cord-028721-x6f26ahr 1756 9 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1756 10 is be VBZ cord-028721-x6f26ahr 1756 11 associated associate VBN cord-028721-x6f26ahr 1756 12 with with IN cord-028721-x6f26ahr 1756 13 a a DT cord-028721-x6f26ahr 1756 14 fi fi NNP cord-028721-x6f26ahr 1756 15 brous brous JJ cord-028721-x6f26ahr 1756 16 streak streak NN cord-028721-x6f26ahr 1756 17 . . . cord-028721-x6f26ahr 1757 1 Most Most JJS cord-028721-x6f26ahr 1757 2 of of IN cord-028721-x6f26ahr 1757 3 the the DT cord-028721-x6f26ahr 1757 4 gonad gonad NN cord-028721-x6f26ahr 1757 5 consists consist VBZ cord-028721-x6f26ahr 1757 6 of of IN cord-028721-x6f26ahr 1757 7 a a DT cord-028721-x6f26ahr 1757 8 testis testis NN cord-028721-x6f26ahr 1757 9 showing show VBG cord-028721-x6f26ahr 1757 10 the the DT cord-028721-x6f26ahr 1757 11 characteristic characteristic JJ cord-028721-x6f26ahr 1757 12 lesions lesion NNS cord-028721-x6f26ahr 1757 13 of of IN cord-028721-x6f26ahr 1757 14 testicular testicular JJ cord-028721-x6f26ahr 1757 15 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1757 16 . . . cord-028721-x6f26ahr 1758 1 In in IN cord-028721-x6f26ahr 1758 2 a a DT cord-028721-x6f26ahr 1758 3 pole pole NN cord-028721-x6f26ahr 1758 4 of of IN cord-028721-x6f26ahr 1758 5 the the DT cord-028721-x6f26ahr 1758 6 gonad gonad NN cord-028721-x6f26ahr 1758 7 , , , cord-028721-x6f26ahr 1758 8 or or CC cord-028721-x6f26ahr 1758 9 in in IN cord-028721-x6f26ahr 1758 10 continuity continuity NN cord-028721-x6f26ahr 1758 11 with with IN cord-028721-x6f26ahr 1758 12 it -PRON- PRP cord-028721-x6f26ahr 1758 13 , , , cord-028721-x6f26ahr 1758 14 there there EX cord-028721-x6f26ahr 1758 15 is be VBZ cord-028721-x6f26ahr 1758 16 a a DT cord-028721-x6f26ahr 1758 17 fi fi NNP cord-028721-x6f26ahr 1758 18 brous brous JJ cord-028721-x6f26ahr 1758 19 streak streak NN cord-028721-x6f26ahr 1758 20 whose whose WP$ cord-028721-x6f26ahr 1758 21 structure structure NN cord-028721-x6f26ahr 1758 22 may may MD cord-028721-x6f26ahr 1758 23 correspond correspond VB cord-028721-x6f26ahr 1758 24 to to IN cord-028721-x6f26ahr 1758 25 any any DT cord-028721-x6f26ahr 1758 26 of of IN cord-028721-x6f26ahr 1758 27 the the DT cord-028721-x6f26ahr 1758 28 varieties variety NNS cord-028721-x6f26ahr 1758 29 mentioned mention VBN cord-028721-x6f26ahr 1758 30 above above RB cord-028721-x6f26ahr 1758 31 ( ( -LRB- cord-028721-x6f26ahr 1758 32 Fig Fig NNP cord-028721-x6f26ahr 1758 33 . . . cord-028721-x6f26ahr 1758 34 12 12 CD cord-028721-x6f26ahr 1758 35 - - SYM cord-028721-x6f26ahr 1758 36 83 83 CD cord-028721-x6f26ahr 1758 37 ) ) -RRB- cord-028721-x6f26ahr 1758 38 . . . cord-028721-x6f26ahr 1759 1 This this DT cord-028721-x6f26ahr 1759 2 peculiar peculiar JJ cord-028721-x6f26ahr 1759 3 gonad gonad NN cord-028721-x6f26ahr 1759 4 can can MD cord-028721-x6f26ahr 1759 5 also also RB cord-028721-x6f26ahr 1759 6 be be VB cord-028721-x6f26ahr 1759 7 observed observe VBN cord-028721-x6f26ahr 1759 8 in in IN cord-028721-x6f26ahr 1759 9 some some DT cord-028721-x6f26ahr 1759 10 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1759 11 male male JJ cord-028721-x6f26ahr 1759 12 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 1759 13 as as RB cord-028721-x6f26ahr 1759 14 well well RB cord-028721-x6f26ahr 1759 15 as as IN cord-028721-x6f26ahr 1759 16 in in IN cord-028721-x6f26ahr 1759 17 the the DT cord-028721-x6f26ahr 1759 18 persistent persistent JJ cord-028721-x6f26ahr 1759 19 mül- mül- NNP cord-028721-x6f26ahr 1759 20 lerian lerian NNP cord-028721-x6f26ahr 1759 21 duct duct NN cord-028721-x6f26ahr 1759 22 syndrome syndrome NN cord-028721-x6f26ahr 1759 23 . . . cord-028721-x6f26ahr 1760 1 In in IN cord-028721-x6f26ahr 1760 2 these these DT cord-028721-x6f26ahr 1760 3 cases case NNS cord-028721-x6f26ahr 1760 4 , , , cord-028721-x6f26ahr 1760 5 the the DT cord-028721-x6f26ahr 1760 6 streak streak NN cord-028721-x6f26ahr 1760 7 contains contain VBZ cord-028721-x6f26ahr 1760 8 no no DT cord-028721-x6f26ahr 1760 9 ovocytes ovocyte NNS cord-028721-x6f26ahr 1760 10 . . . cord-028721-x6f26ahr 1761 1 Light light JJ cord-028721-x6f26ahr 1761 2 microscopy microscopy NN cord-028721-x6f26ahr 1761 3 indicates indicate VBZ cord-028721-x6f26ahr 1761 4 a a DT cord-028721-x6f26ahr 1761 5 wide wide JJ cord-028721-x6f26ahr 1761 6 spectrum spectrum NN cord-028721-x6f26ahr 1761 7 of of IN cord-028721-x6f26ahr 1761 8 testicular testicular JJ cord-028721-x6f26ahr 1761 9 lesions lesion NNS cord-028721-x6f26ahr 1761 10 , , , cord-028721-x6f26ahr 1761 11 ranging range VBG cord-028721-x6f26ahr 1761 12 from from IN cord-028721-x6f26ahr 1761 13 those those DT cord-028721-x6f26ahr 1761 14 of of IN cord-028721-x6f26ahr 1761 15 patients patient NNS cord-028721-x6f26ahr 1761 16 with with IN cord-028721-x6f26ahr 1761 17 46XY 46xy CD cord-028721-x6f26ahr 1761 18 pure pure JJ cord-028721-x6f26ahr 1761 19 gonadal gonadal JJ cord-028721-x6f26ahr 1761 20 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1761 21 to to IN cord-028721-x6f26ahr 1761 22 true true JJ cord-028721-x6f26ahr 1761 23 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1761 24 . . . cord-028721-x6f26ahr 1762 1 Differentiation differentiation NN cord-028721-x6f26ahr 1762 2 of of IN cord-028721-x6f26ahr 1762 3 the the DT cord-028721-x6f26ahr 1762 4 ovocyte ovocyte NN cord-028721-x6f26ahr 1762 5 - - HYPH cord-028721-x6f26ahr 1762 6 containing contain VBG cord-028721-x6f26ahr 1762 7 streak streak NN cord-028721-x6f26ahr 1762 8 testis testis NN cord-028721-x6f26ahr 1762 9 and and CC cord-028721-x6f26ahr 1762 10 ovotestis ovotestis NNP cord-028721-x6f26ahr 1762 11 remains remain VBZ cord-028721-x6f26ahr 1762 12 controversial controversial JJ cord-028721-x6f26ahr 1762 13 . . . cord-028721-x6f26ahr 1763 1 796 796 CD cord-028721-x6f26ahr 1763 2 , , , cord-028721-x6f26ahr 1763 3 797 797 CD cord-028721-x6f26ahr 1764 1 The the DT cord-028721-x6f26ahr 1764 2 testes testis NNS cord-028721-x6f26ahr 1764 3 in in IN cord-028721-x6f26ahr 1764 4 mixed mixed JJ cord-028721-x6f26ahr 1764 5 gonadal gonadal JJ cord-028721-x6f26ahr 1764 6 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1764 7 are be VBP cord-028721-x6f26ahr 1764 8 incapable incapable JJ cord-028721-x6f26ahr 1764 9 of of IN cord-028721-x6f26ahr 1764 10 müllerian müllerian JJ cord-028721-x6f26ahr 1764 11 duct duct NN cord-028721-x6f26ahr 1764 12 inhibition inhibition NN cord-028721-x6f26ahr 1764 13 and and CC cord-028721-x6f26ahr 1764 14 allow allow VB cord-028721-x6f26ahr 1764 15 complete complete JJ cord-028721-x6f26ahr 1764 16 differentiation differentiation NN cord-028721-x6f26ahr 1764 17 of of IN cord-028721-x6f26ahr 1764 18 wolffi wolffi NNP cord-028721-x6f26ahr 1764 19 an an DT cord-028721-x6f26ahr 1764 20 derivatives derivative NNS cord-028721-x6f26ahr 1764 21 , , , cord-028721-x6f26ahr 1764 22 virilization virilization NN cord-028721-x6f26ahr 1764 23 of of IN cord-028721-x6f26ahr 1764 24 external external JJ cord-028721-x6f26ahr 1764 25 genitalia genitalia NNS cord-028721-x6f26ahr 1764 26 , , , cord-028721-x6f26ahr 1764 27 and and CC cord-028721-x6f26ahr 1764 28 , , , cord-028721-x6f26ahr 1764 29 in in IN cord-028721-x6f26ahr 1764 30 most most JJS cord-028721-x6f26ahr 1764 31 cases case NNS cord-028721-x6f26ahr 1764 32 , , , cord-028721-x6f26ahr 1764 33 testicular testicular JJ cord-028721-x6f26ahr 1764 34 descent descent NN cord-028721-x6f26ahr 1764 35 . . . cord-028721-x6f26ahr 1765 1 The the DT cord-028721-x6f26ahr 1765 2 risk risk NN cord-028721-x6f26ahr 1765 3 of of IN cord-028721-x6f26ahr 1765 4 germ germ NN cord-028721-x6f26ahr 1765 5 cell cell NN cord-028721-x6f26ahr 1765 6 neoplasia neoplasia NN cord-028721-x6f26ahr 1765 7 reaches reach VBZ cord-028721-x6f26ahr 1765 8 50 50 CD cord-028721-x6f26ahr 1765 9 % % NN cord-028721-x6f26ahr 1765 10 in in IN cord-028721-x6f26ahr 1765 11 the the DT cord-028721-x6f26ahr 1765 12 third third JJ cord-028721-x6f26ahr 1765 13 decade decade NN cord-028721-x6f26ahr 1765 14 of of IN cord-028721-x6f26ahr 1765 15 life life NN cord-028721-x6f26ahr 1765 16 , , , cord-028721-x6f26ahr 1765 17 usually usually RB cord-028721-x6f26ahr 1765 18 beginning begin VBG cord-028721-x6f26ahr 1765 19 with with IN cord-028721-x6f26ahr 1765 20 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1765 21 . . . cord-028721-x6f26ahr 1766 1 The the DT cord-028721-x6f26ahr 1766 2 testes testis NNS cord-028721-x6f26ahr 1766 3 should should MD cord-028721-x6f26ahr 1766 4 be be VB cord-028721-x6f26ahr 1766 5 removed remove VBN cord-028721-x6f26ahr 1766 6 after after IN cord-028721-x6f26ahr 1766 7 puberty puberty NN cord-028721-x6f26ahr 1766 8 . . . cord-028721-x6f26ahr 1767 1 Dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1767 2 male male JJ cord-028721-x6f26ahr 1767 3 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1767 4 is be VBZ cord-028721-x6f26ahr 1767 5 a a DT cord-028721-x6f26ahr 1767 6 disorder disorder NN cord-028721-x6f26ahr 1767 7 of of IN cord-028721-x6f26ahr 1767 8 sexual sexual JJ cord-028721-x6f26ahr 1767 9 differentiation differentiation NN cord-028721-x6f26ahr 1767 10 characterized characterize VBN cord-028721-x6f26ahr 1767 11 by by IN cord-028721-x6f26ahr 1767 12 bilateral bilateral JJ cord-028721-x6f26ahr 1767 13 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1767 14 testes testis NNS cord-028721-x6f26ahr 1767 15 or or CC cord-028721-x6f26ahr 1767 16 streak streak NN cord-028721-x6f26ahr 1767 17 testis testis NN cord-028721-x6f26ahr 1767 18 , , , cord-028721-x6f26ahr 1767 19 persistent persistent JJ cord-028721-x6f26ahr 1767 20 müllerian müllerian JJ cord-028721-x6f26ahr 1767 21 structures structure NNS cord-028721-x6f26ahr 1767 22 , , , cord-028721-x6f26ahr 1767 23 and and CC cord-028721-x6f26ahr 1767 24 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1767 25 . . . cord-028721-x6f26ahr 1768 1 This this DT cord-028721-x6f26ahr 1768 2 syndrome syndrome NN cord-028721-x6f26ahr 1768 3 is be VBZ cord-028721-x6f26ahr 1768 4 considered consider VBN cord-028721-x6f26ahr 1768 5 a a DT cord-028721-x6f26ahr 1768 6 variant variant NN cord-028721-x6f26ahr 1768 7 of of IN cord-028721-x6f26ahr 1768 8 mixed mixed JJ cord-028721-x6f26ahr 1768 9 gonadal gonadal JJ cord-028721-x6f26ahr 1768 10 dysgenesis dysgenesis FW cord-028721-x6f26ahr 1768 11 ( ( -LRB- cord-028721-x6f26ahr 1768 12 Fig Fig NNP cord-028721-x6f26ahr 1768 13 . . . cord-028721-x6f26ahr 1768 14 12 12 CD cord-028721-x6f26ahr 1768 15 - - SYM cord-028721-x6f26ahr 1768 16 84 84 CD cord-028721-x6f26ahr 1768 17 ) ) -RRB- cord-028721-x6f26ahr 1768 18 . . . cord-028721-x6f26ahr 1769 1 791 791 CD cord-028721-x6f26ahr 1769 2 , , , cord-028721-x6f26ahr 1769 3 798 798 CD cord-028721-x6f26ahr 1770 1 The the DT cord-028721-x6f26ahr 1770 2 karyotype karyotype NN cord-028721-x6f26ahr 1770 3 may may MD cord-028721-x6f26ahr 1770 4 be be VB cord-028721-x6f26ahr 1770 5 46XY 46xy CD cord-028721-x6f26ahr 1770 6 or or CC cord-028721-x6f26ahr 1770 7 45X0/46XY 45x0/46xy CD cord-028721-x6f26ahr 1770 8 , , , cord-028721-x6f26ahr 1770 9 and and CC cord-028721-x6f26ahr 1770 10 turnerian turnerian NN cord-028721-x6f26ahr 1770 11 stigmata stigmata NN cord-028721-x6f26ahr 1770 12 may may MD cord-028721-x6f26ahr 1770 13 be be VB cord-028721-x6f26ahr 1770 14 present present JJ cord-028721-x6f26ahr 1770 15 . . . cord-028721-x6f26ahr 1771 1 The the DT cord-028721-x6f26ahr 1771 2 uterus uterus NN cord-028721-x6f26ahr 1771 3 and and CC cord-028721-x6f26ahr 1771 4 fallopian fallopian JJ cord-028721-x6f26ahr 1771 5 tubes tube NNS cord-028721-x6f26ahr 1771 6 are be VBP cord-028721-x6f26ahr 1771 7 present present JJ cord-028721-x6f26ahr 1771 8 and and CC cord-028721-x6f26ahr 1771 9 both both DT cord-028721-x6f26ahr 1771 10 are be VBP cord-028721-x6f26ahr 1771 11 usually usually RB cord-028721-x6f26ahr 1771 12 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 1772 1 ( ( -LRB- cord-028721-x6f26ahr 1772 2 Fig Fig NNP cord-028721-x6f26ahr 1772 3 . . . cord-028721-x6f26ahr 1772 4 12 12 CD cord-028721-x6f26ahr 1772 5 - - SYM cord-028721-x6f26ahr 1772 6 85 85 CD cord-028721-x6f26ahr 1772 7 ) ) -RRB- cord-028721-x6f26ahr 1772 8 . . . cord-028721-x6f26ahr 1773 1 799 799 CD cord-028721-x6f26ahr 1774 1 The the DT cord-028721-x6f26ahr 1774 2 testes testis NNS cord-028721-x6f26ahr 1774 3 show show VBP cord-028721-x6f26ahr 1774 4 lesions lesion NNS cord-028721-x6f26ahr 1774 5 characteristic characteristic JJ cord-028721-x6f26ahr 1774 6 of of IN cord-028721-x6f26ahr 1774 7 testicular testicular JJ cord-028721-x6f26ahr 1774 8 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 1774 9 , , , cord-028721-x6f26ahr 1774 10 with with IN cord-028721-x6f26ahr 1774 11 few few JJ cord-028721-x6f26ahr 1774 12 germ germ NN cord-028721-x6f26ahr 1774 13 cells cell NNS cord-028721-x6f26ahr 1774 14 during during IN cord-028721-x6f26ahr 1774 15 childhood childhood NN cord-028721-x6f26ahr 1774 16 ( ( -LRB- cord-028721-x6f26ahr 1774 17 Fig Fig NNP cord-028721-x6f26ahr 1774 18 . . . cord-028721-x6f26ahr 1774 19 12 12 CD cord-028721-x6f26ahr 1774 20 - - SYM cord-028721-x6f26ahr 1774 21 85 85 CD cord-028721-x6f26ahr 1774 22 ) ) -RRB- cord-028721-x6f26ahr 1774 23 . . . cord-028721-x6f26ahr 1775 1 799 799 CD cord-028721-x6f26ahr 1776 1 In in IN cord-028721-x6f26ahr 1776 2 adults adult NNS cord-028721-x6f26ahr 1776 3 , , , cord-028721-x6f26ahr 1776 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1776 5 is be VBZ cord-028721-x6f26ahr 1776 6 poorly poorly RB cord-028721-x6f26ahr 1776 7 developed develop VBN cord-028721-x6f26ahr 1776 8 and and CC cord-028721-x6f26ahr 1776 9 the the DT cord-028721-x6f26ahr 1776 10 testicular testicular JJ cord-028721-x6f26ahr 1776 11 interstitium interstitium NN cord-028721-x6f26ahr 1776 12 shows show VBZ cord-028721-x6f26ahr 1776 13 Leydig Leydig NNP cord-028721-x6f26ahr 1776 14 cell cell NN cord-028721-x6f26ahr 1776 15 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1776 16 . . . cord-028721-x6f26ahr 1777 1 About about RB cord-028721-x6f26ahr 1777 2 25 25 CD cord-028721-x6f26ahr 1777 3 % % NN cord-028721-x6f26ahr 1777 4 of of IN cord-028721-x6f26ahr 1777 5 patients patient NNS cord-028721-x6f26ahr 1777 6 develop develop VB cord-028721-x6f26ahr 1777 7 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1777 8 . . . cord-028721-x6f26ahr 1778 1 800 800 CD cord-028721-x6f26ahr 1779 1 Persistent persistent JJ cord-028721-x6f26ahr 1779 2 müllerian müllerian JJ cord-028721-x6f26ahr 1779 3 duct duct NN cord-028721-x6f26ahr 1779 4 syndrome syndrome NN cord-028721-x6f26ahr 1779 5 has have VBZ cord-028721-x6f26ahr 1779 6 many many JJ cord-028721-x6f26ahr 1779 7 names name NNS cord-028721-x6f26ahr 1779 8 , , , cord-028721-x6f26ahr 1779 9 including include VBG cord-028721-x6f26ahr 1779 10 male male JJ cord-028721-x6f26ahr 1779 11 with with IN cord-028721-x6f26ahr 1779 12 uterus uterus NN cord-028721-x6f26ahr 1779 13 , , , cord-028721-x6f26ahr 1779 14 tubular tubular JJ cord-028721-x6f26ahr 1779 15 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1779 16 , , , cord-028721-x6f26ahr 1779 17 persistent persistent JJ cord-028721-x6f26ahr 1779 18 oviduct oviduct NN cord-028721-x6f26ahr 1779 19 syndrome syndrome NN cord-028721-x6f26ahr 1779 20 , , , cord-028721-x6f26ahr 1779 21 and and CC cord-028721-x6f26ahr 1779 22 hernia hernia NNP cord-028721-x6f26ahr 1779 23 uteri uterus NNS cord-028721-x6f26ahr 1779 24 inguinalis inguinalis NNP cord-028721-x6f26ahr 1779 25 . . . cord-028721-x6f26ahr 1780 1 801 801 CD cord-028721-x6f26ahr 1781 1 It -PRON- PRP cord-028721-x6f26ahr 1781 2 is be VBZ cord-028721-x6f26ahr 1781 3 a a DT cord-028721-x6f26ahr 1781 4 rare rare JJ cord-028721-x6f26ahr 1781 5 form form NN cord-028721-x6f26ahr 1781 6 of of IN cord-028721-x6f26ahr 1781 7 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1781 8 , , , cord-028721-x6f26ahr 1781 9 with with IN cord-028721-x6f26ahr 1781 10 müllerian müllerian JJ cord-028721-x6f26ahr 1781 11 derivatives derivative NNS cord-028721-x6f26ahr 1781 12 in in IN cord-028721-x6f26ahr 1781 13 an an DT cord-028721-x6f26ahr 1781 14 otherwise otherwise RB cord-028721-x6f26ahr 1781 15 phenotypically phenotypically RB cord-028721-x6f26ahr 1781 16 normal normal JJ cord-028721-x6f26ahr 1781 17 male male NN cord-028721-x6f26ahr 1781 18 , , , cord-028721-x6f26ahr 1781 19 and and CC cord-028721-x6f26ahr 1781 20 is be VBZ cord-028721-x6f26ahr 1781 21 the the DT cord-028721-x6f26ahr 1781 22 most most RBS cord-028721-x6f26ahr 1781 23 characteristic characteristic JJ cord-028721-x6f26ahr 1781 24 form form NN cord-028721-x6f26ahr 1781 25 of of IN cord-028721-x6f26ahr 1781 26 isolated isolated JJ cord-028721-x6f26ahr 1781 27 anti anti JJ cord-028721-x6f26ahr 1781 28 - - JJ cord-028721-x6f26ahr 1781 29 müllerian müllerian JJ cord-028721-x6f26ahr 1781 30 hormone hormone NN cord-028721-x6f26ahr 1781 31 defi defi NNP cord-028721-x6f26ahr 1781 32 ciency ciency NNP cord-028721-x6f26ahr 1781 33 . . . cord-028721-x6f26ahr 1782 1 The the DT cord-028721-x6f26ahr 1782 2 molecular molecular JJ cord-028721-x6f26ahr 1782 3 basis basis NN cord-028721-x6f26ahr 1782 4 of of IN cord-028721-x6f26ahr 1782 5 this this DT cord-028721-x6f26ahr 1782 6 syndrome syndrome NN cord-028721-x6f26ahr 1782 7 is be VBZ cord-028721-x6f26ahr 1782 8 heterogeneous heterogeneous JJ cord-028721-x6f26ahr 1782 9 . . . cord-028721-x6f26ahr 1783 1 Three three CD cord-028721-x6f26ahr 1783 2 hypotheses hypothesis NNS cord-028721-x6f26ahr 1783 3 have have VBP cord-028721-x6f26ahr 1783 4 been be VBN cord-028721-x6f26ahr 1783 5 proposed propose VBN cord-028721-x6f26ahr 1783 6 , , , cord-028721-x6f26ahr 1783 7 including include VBG cord-028721-x6f26ahr 1783 8 a a DT cord-028721-x6f26ahr 1783 9 defect defect NN cord-028721-x6f26ahr 1783 10 in in IN cord-028721-x6f26ahr 1783 11 anti anti JJ cord-028721-x6f26ahr 1783 12 - - JJ cord-028721-x6f26ahr 1783 13 müllerian müllerian JJ cord-028721-x6f26ahr 1783 14 hormone hormone NN cord-028721-x6f26ahr 1783 15 synthesis synthesis NN cord-028721-x6f26ahr 1783 16 , , , cord-028721-x6f26ahr 1783 17 caused cause VBN cord-028721-x6f26ahr 1783 18 by by IN cord-028721-x6f26ahr 1783 19 mutation mutation NN cord-028721-x6f26ahr 1783 20 in in IN cord-028721-x6f26ahr 1783 21 the the DT cord-028721-x6f26ahr 1783 22 anti anti JJ cord-028721-x6f26ahr 1783 23 - - JJ cord-028721-x6f26ahr 1783 24 müllerian müllerian JJ cord-028721-x6f26ahr 1783 25 hormone hormone NN cord-028721-x6f26ahr 1783 26 gene gene NN cord-028721-x6f26ahr 1783 27 ( ( -LRB- cord-028721-x6f26ahr 1783 28 45 45 CD cord-028721-x6f26ahr 1783 29 % % NN cord-028721-x6f26ahr 1783 30 of of IN cord-028721-x6f26ahr 1783 31 cases case NNS cord-028721-x6f26ahr 1783 32 ) ) -RRB- cord-028721-x6f26ahr 1783 33 ; ; : cord-028721-x6f26ahr 1783 34 resistance resistance NN cord-028721-x6f26ahr 1783 35 of of IN cord-028721-x6f26ahr 1783 36 target target NN cord-028721-x6f26ahr 1783 37 organs organ NNS cord-028721-x6f26ahr 1783 38 to to IN cord-028721-x6f26ahr 1783 39 this this DT cord-028721-x6f26ahr 1783 40 hormone hormone NN cord-028721-x6f26ahr 1783 41 , , , cord-028721-x6f26ahr 1783 42 caused cause VBN cord-028721-x6f26ahr 1783 43 by by IN cord-028721-x6f26ahr 1783 44 mutation mutation NN cord-028721-x6f26ahr 1783 45 in in IN cord-028721-x6f26ahr 1783 46 the the DT cord-028721-x6f26ahr 1783 47 receptor receptor NN cord-028721-x6f26ahr 1783 48 II II NNP cord-028721-x6f26ahr 1783 49 for for IN cord-028721-x6f26ahr 1783 50 this this DT cord-028721-x6f26ahr 1783 51 hormone hormone NN cord-028721-x6f26ahr 1783 52 ( ( -LRB- cord-028721-x6f26ahr 1783 53 39 39 CD cord-028721-x6f26ahr 1783 54 % % NN cord-028721-x6f26ahr 1783 55 of of IN cord-028721-x6f26ahr 1783 56 cases case NNS cord-028721-x6f26ahr 1783 57 ) ) -RRB- cord-028721-x6f26ahr 1783 58 ; ; : cord-028721-x6f26ahr 1783 59 and and CC cord-028721-x6f26ahr 1783 60 failure failure NN cord-028721-x6f26ahr 1783 61 in in IN cord-028721-x6f26ahr 1783 62 the the DT cord-028721-x6f26ahr 1783 63 action action NN cord-028721-x6f26ahr 1783 64 of of IN cord-028721-x6f26ahr 1783 65 this this DT cord-028721-x6f26ahr 1783 66 hormone hormone NN cord-028721-x6f26ahr 1783 67 immediately immediately RB cord-028721-x6f26ahr 1783 68 before before IN cord-028721-x6f26ahr 1783 69 the the DT cord-028721-x6f26ahr 1783 70 eighth eighth JJ cord-028721-x6f26ahr 1783 71 week week NN cord-028721-x6f26ahr 1783 72 of of IN cord-028721-x6f26ahr 1783 73 gestation gestation NN cord-028721-x6f26ahr 1783 74 ( ( -LRB- cord-028721-x6f26ahr 1783 75 16 16 CD cord-028721-x6f26ahr 1783 76 % % NN cord-028721-x6f26ahr 1783 77 of of IN cord-028721-x6f26ahr 1783 78 cases case NNS cord-028721-x6f26ahr 1783 79 ) ) -RRB- cord-028721-x6f26ahr 1783 80 . . . cord-028721-x6f26ahr 1784 1 802 802 CD cord-028721-x6f26ahr 1785 1 Although although IN cord-028721-x6f26ahr 1785 2 the the DT cord-028721-x6f26ahr 1785 3 external external JJ cord-028721-x6f26ahr 1785 4 genitalia genitalia NNS cord-028721-x6f26ahr 1785 5 are be VBP cord-028721-x6f26ahr 1785 6 male male JJ cord-028721-x6f26ahr 1785 7 , , , cord-028721-x6f26ahr 1785 8 one one CD cord-028721-x6f26ahr 1785 9 ( ( -LRB- cord-028721-x6f26ahr 1785 10 35 35 CD cord-028721-x6f26ahr 1785 11 % % NN cord-028721-x6f26ahr 1785 12 of of IN cord-028721-x6f26ahr 1785 13 cases case NNS cord-028721-x6f26ahr 1785 14 ) ) -RRB- cord-028721-x6f26ahr 1785 15 or or CC cord-028721-x6f26ahr 1785 16 both both DT cord-028721-x6f26ahr 1785 17 testes testis NNS cord-028721-x6f26ahr 1785 18 ( ( -LRB- cord-028721-x6f26ahr 1785 19 75 75 CD cord-028721-x6f26ahr 1785 20 % % NN cord-028721-x6f26ahr 1785 21 of of IN cord-028721-x6f26ahr 1785 22 cases case NNS cord-028721-x6f26ahr 1785 23 ) ) -RRB- cord-028721-x6f26ahr 1785 24 are be VBP cord-028721-x6f26ahr 1785 25 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1785 26 . . . cord-028721-x6f26ahr 1786 1 The the DT cord-028721-x6f26ahr 1786 2 syndrome syndrome NN cord-028721-x6f26ahr 1786 3 usually usually RB cord-028721-x6f26ahr 1786 4 also also RB cord-028721-x6f26ahr 1786 5 includes include VBZ cord-028721-x6f26ahr 1786 6 inguinal inguinal JJ cord-028721-x6f26ahr 1786 7 hernia hernia NN cord-028721-x6f26ahr 1786 8 contralateral contralateral NN cord-028721-x6f26ahr 1786 9 to to IN cord-028721-x6f26ahr 1786 10 the the DT cord-028721-x6f26ahr 1786 11 undescended undescended JJ cord-028721-x6f26ahr 1786 12 testis testis NN cord-028721-x6f26ahr 1786 13 , , , cord-028721-x6f26ahr 1786 14 with with IN cord-028721-x6f26ahr 1786 15 a a DT cord-028721-x6f26ahr 1786 16 uterus uterus NN cord-028721-x6f26ahr 1786 17 and and CC cord-028721-x6f26ahr 1786 18 fallopian fallopian JJ cord-028721-x6f26ahr 1786 19 tubes tube NNS cord-028721-x6f26ahr 1786 20 within within IN cord-028721-x6f26ahr 1786 21 the the DT cord-028721-x6f26ahr 1786 22 hernia hernia NN cord-028721-x6f26ahr 1786 23 sac sac NN cord-028721-x6f26ahr 1786 24 ( ( -LRB- cord-028721-x6f26ahr 1786 25 Figs Figs NNP cord-028721-x6f26ahr 1786 26 12 12 CD cord-028721-x6f26ahr 1786 27 - - SYM cord-028721-x6f26ahr 1786 28 86 86 CD cord-028721-x6f26ahr 1786 29 , , , cord-028721-x6f26ahr 1786 30 12 12 CD cord-028721-x6f26ahr 1786 31 - - SYM cord-028721-x6f26ahr 1786 32 87 87 CD cord-028721-x6f26ahr 1786 33 ) ) -RRB- cord-028721-x6f26ahr 1786 34 . . . cord-028721-x6f26ahr 1787 1 803 803 CD cord-028721-x6f26ahr 1787 2 Several several JJ cord-028721-x6f26ahr 1787 3 cases case NNS cord-028721-x6f26ahr 1787 4 with with IN cord-028721-x6f26ahr 1787 5 transverse transverse JJ cord-028721-x6f26ahr 1787 6 testicular testicular JJ cord-028721-x6f26ahr 1787 7 ectopia ectopia NN cord-028721-x6f26ahr 1787 8 and and CC cord-028721-x6f26ahr 1787 9 persistent persistent JJ cord-028721-x6f26ahr 1787 10 müllerian müllerian JJ cord-028721-x6f26ahr 1787 11 duct duct NN cord-028721-x6f26ahr 1787 12 structures structure NNS cord-028721-x6f26ahr 1787 13 have have VBP cord-028721-x6f26ahr 1787 14 been be VBN cord-028721-x6f26ahr 1787 15 reported report VBN cord-028721-x6f26ahr 1787 16 . . . cord-028721-x6f26ahr 1788 1 804 804 CD cord-028721-x6f26ahr 1788 2 , , , cord-028721-x6f26ahr 1788 3 805 805 CD cord-028721-x6f26ahr 1789 1 Patients patient NNS cord-028721-x6f26ahr 1789 2 usually usually RB cord-028721-x6f26ahr 1789 3 have have VBP cord-028721-x6f26ahr 1789 4 inguinal inguinal JJ cord-028721-x6f26ahr 1789 5 hernia hernia NN cord-028721-x6f26ahr 1789 6 , , , cord-028721-x6f26ahr 1789 7 but but CC cord-028721-x6f26ahr 1789 8 others other NNS cord-028721-x6f26ahr 1789 9 have have VBP cord-028721-x6f26ahr 1789 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1789 11 , , , cord-028721-x6f26ahr 1789 12 infertility infertility NN cord-028721-x6f26ahr 1789 13 , , , cord-028721-x6f26ahr 1789 14 806 806 CD cord-028721-x6f26ahr 1789 15 and and CC cord-028721-x6f26ahr 1789 16 testicular testicular JJ cord-028721-x6f26ahr 1789 17 tumor tumor NN cord-028721-x6f26ahr 1789 18 . . . cord-028721-x6f26ahr 1790 1 807 807 CD cord-028721-x6f26ahr 1791 1 In in IN cord-028721-x6f26ahr 1791 2 childhood childhood NN cord-028721-x6f26ahr 1791 3 , , , cord-028721-x6f26ahr 1791 4 the the DT cord-028721-x6f26ahr 1791 5 testes testis NNS cord-028721-x6f26ahr 1791 6 have have VBP cord-028721-x6f26ahr 1791 7 a a DT cord-028721-x6f26ahr 1791 8 low low JJ cord-028721-x6f26ahr 1791 9 tubular tubular JJ cord-028721-x6f26ahr 1791 10 fertility fertility NN cord-028721-x6f26ahr 1791 11 index index NN cord-028721-x6f26ahr 1791 12 and and CC cord-028721-x6f26ahr 1791 13 decreased decrease VBD cord-028721-x6f26ahr 1791 14 tubular tubular JJ cord-028721-x6f26ahr 1791 15 diameter diameter NN cord-028721-x6f26ahr 1791 16 . . . cord-028721-x6f26ahr 1792 1 In in IN cord-028721-x6f26ahr 1792 2 adults adult NNS cord-028721-x6f26ahr 1792 3 , , , cord-028721-x6f26ahr 1792 4 the the DT cord-028721-x6f26ahr 1792 5 tunica tunica NNP cord-028721-x6f26ahr 1792 6 albu- albu- NNP cord-028721-x6f26ahr 1792 7 ginea ginea NNP cord-028721-x6f26ahr 1792 8 is be VBZ cord-028721-x6f26ahr 1792 9 variably variably RB cord-028721-x6f26ahr 1792 10 thickened thicken VBN cord-028721-x6f26ahr 1792 11 , , , cord-028721-x6f26ahr 1792 12 contains contain VBZ cord-028721-x6f26ahr 1792 13 connective connective JJ cord-028721-x6f26ahr 1792 14 tissue tissue NN cord-028721-x6f26ahr 1792 15 resembling resemble VBG cord-028721-x6f26ahr 1792 16 ovarian ovarian JJ cord-028721-x6f26ahr 1792 17 stroma stroma NN cord-028721-x6f26ahr 1792 18 , , , cord-028721-x6f26ahr 1792 19 and and CC cord-028721-x6f26ahr 1792 20 may may MD cord-028721-x6f26ahr 1792 21 contain contain VB cord-028721-x6f26ahr 1792 22 tubular tubular JJ cord-028721-x6f26ahr 1792 23 structures structure NNS cord-028721-x6f26ahr 1792 24 -alterations -alteration VBZ cord-028721-x6f26ahr 1792 25 typical typical JJ cord-028721-x6f26ahr 1792 26 of of IN cord-028721-x6f26ahr 1792 27 testicular testicular JJ cord-028721-x6f26ahr 1792 28 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1792 29 . . . cord-028721-x6f26ahr 1793 1 The the DT cord-028721-x6f26ahr 1793 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1793 3 tubules tubule NNS cord-028721-x6f26ahr 1793 4 are be VBP cord-028721-x6f26ahr 1793 5 usually usually RB cord-028721-x6f26ahr 1793 6 atrophic atrophic JJ cord-028721-x6f26ahr 1793 7 and and CC cord-028721-x6f26ahr 1793 8 hyalinized hyalinized JJ cord-028721-x6f26ahr 1793 9 . . . cord-028721-x6f26ahr 1794 1 Tubules Tubules NNP cord-028721-x6f26ahr 1794 2 with with IN cord-028721-x6f26ahr 1794 3 reduced reduce VBN cord-028721-x6f26ahr 1794 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1794 5 or or CC cord-028721-x6f26ahr 1794 6 patterns pattern NNS cord-028721-x6f26ahr 1794 7 suggesting suggest VBG cord-028721-x6f26ahr 1794 8 mixed mixed JJ cord-028721-x6f26ahr 1794 9 atrophy atrophy NN cord-028721-x6f26ahr 1794 10 ( ( -LRB- cord-028721-x6f26ahr 1794 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 1794 12 tubules tubule NNS cord-028721-x6f26ahr 1794 13 with with IN cord-028721-x6f26ahr 1794 14 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1794 15 intermingled intermingle VBN cord-028721-x6f26ahr 1794 16 with with IN cord-028721-x6f26ahr 1794 17 Sertoli sertoli JJ cord-028721-x6f26ahr 1794 18 cell cell NN cord-028721-x6f26ahr 1794 19 - - HYPH cord-028721-x6f26ahr 1794 20 only only RB cord-028721-x6f26ahr 1794 21 tubules tubule NNS cord-028721-x6f26ahr 1794 22 ) ) -RRB- cord-028721-x6f26ahr 1794 23 have have VBP cord-028721-x6f26ahr 1794 24 also also RB cord-028721-x6f26ahr 1794 25 been be VBN cord-028721-x6f26ahr 1794 26 reported report VBN cord-028721-x6f26ahr 1794 27 . . . cord-028721-x6f26ahr 1795 1 The the DT cord-028721-x6f26ahr 1795 2 Leydig Leydig NNP cord-028721-x6f26ahr 1795 3 cells cell NNS cord-028721-x6f26ahr 1795 4 appear appear VBP cord-028721-x6f26ahr 1795 5 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 1795 6 . . . cord-028721-x6f26ahr 1796 1 Azoospermia azoospermia NN cord-028721-x6f26ahr 1796 2 or or CC cord-028721-x6f26ahr 1796 3 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 1796 4 are be VBP cord-028721-x6f26ahr 1796 5 common common JJ cord-028721-x6f26ahr 1796 6 , , , cord-028721-x6f26ahr 1796 7 and and CC cord-028721-x6f26ahr 1796 8 paternity paternity NN cord-028721-x6f26ahr 1796 9 is be VBZ cord-028721-x6f26ahr 1796 10 exceptional exceptional JJ cord-028721-x6f26ahr 1796 11 . . . cord-028721-x6f26ahr 1797 1 808 808 CD cord-028721-x6f26ahr 1798 1 The the DT cord-028721-x6f26ahr 1798 2 syndrome syndrome NN cord-028721-x6f26ahr 1798 3 is be VBZ cord-028721-x6f26ahr 1798 4 sporadic sporadic JJ cord-028721-x6f26ahr 1798 5 or or CC cord-028721-x6f26ahr 1798 6 familial familial JJ cord-028721-x6f26ahr 1798 7 , , , cord-028721-x6f26ahr 1798 8 with with IN cord-028721-x6f26ahr 1798 9 autosomal autosomal JJ cord-028721-x6f26ahr 1798 10 recessive recessive JJ cord-028721-x6f26ahr 1798 11 or or CC cord-028721-x6f26ahr 1798 12 X X NNS cord-028721-x6f26ahr 1798 13 - - HYPH cord-028721-x6f26ahr 1798 14 linked link VBN cord-028721-x6f26ahr 1798 15 inheritance inheritance NN cord-028721-x6f26ahr 1798 16 . . . cord-028721-x6f26ahr 1799 1 809 809 CD cord-028721-x6f26ahr 1799 2 , , , cord-028721-x6f26ahr 1799 3 810 810 CD cord-028721-x6f26ahr 1800 1 These these DT cord-028721-x6f26ahr 1800 2 patients patient NNS cord-028721-x6f26ahr 1800 3 have have VBP cord-028721-x6f26ahr 1800 4 a a DT cord-028721-x6f26ahr 1800 5 higher high JJR cord-028721-x6f26ahr 1800 6 risk risk NN cord-028721-x6f26ahr 1800 7 of of IN cord-028721-x6f26ahr 1800 8 testicular testicular JJ cord-028721-x6f26ahr 1800 9 tumor tumor NN cord-028721-x6f26ahr 1800 10 than than IN cord-028721-x6f26ahr 1800 11 that that DT cord-028721-x6f26ahr 1800 12 attributed attribute VBN cord-028721-x6f26ahr 1800 13 to to IN cord-028721-x6f26ahr 1800 14 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1800 15 , , , cord-028721-x6f26ahr 1800 16 811 811 CD cord-028721-x6f26ahr 1800 17 and and CC cord-028721-x6f26ahr 1800 18 all all DT cord-028721-x6f26ahr 1800 19 types type NNS cord-028721-x6f26ahr 1800 20 of of IN cord-028721-x6f26ahr 1800 21 germ germ NN cord-028721-x6f26ahr 1800 22 cell cell NN cord-028721-x6f26ahr 1800 23 tumor tumor NN cord-028721-x6f26ahr 1800 24 have have VBP cord-028721-x6f26ahr 1800 25 been be VBN cord-028721-x6f26ahr 1800 26 observed observe VBN cord-028721-x6f26ahr 1800 27 . . . cord-028721-x6f26ahr 1801 1 812 812 CD cord-028721-x6f26ahr 1801 2 , , , cord-028721-x6f26ahr 1801 3 813 813 CD cord-028721-x6f26ahr 1801 4 Other other JJ cord-028721-x6f26ahr 1801 5 forms form NNS cord-028721-x6f26ahr 1801 6 of of IN cord-028721-x6f26ahr 1801 7 male male JJ cord-028721-x6f26ahr 1801 8 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1801 9 Of of IN cord-028721-x6f26ahr 1801 10 the the DT cord-028721-x6f26ahr 1801 11 dysmorphic dysmorphic JJ cord-028721-x6f26ahr 1801 12 syndromes syndrome NNS cord-028721-x6f26ahr 1801 13 associated associate VBN cord-028721-x6f26ahr 1801 14 with with IN cord-028721-x6f26ahr 1801 15 incomplete incomplete JJ cord-028721-x6f26ahr 1801 16 virilization virilization NN cord-028721-x6f26ahr 1801 17 of of IN cord-028721-x6f26ahr 1801 18 external external JJ cord-028721-x6f26ahr 1801 19 genitalia genitalia NNS cord-028721-x6f26ahr 1801 20 , , , cord-028721-x6f26ahr 1801 21 the the DT cord-028721-x6f26ahr 1801 22 best well RBS cord-028721-x6f26ahr 1801 23 - - HYPH cord-028721-x6f26ahr 1801 24 known know VBN cord-028721-x6f26ahr 1801 25 are be VBP cord-028721-x6f26ahr 1801 26 those those DT cord-028721-x6f26ahr 1801 27 of of IN cord-028721-x6f26ahr 1801 28 RSH rsh NN cord-028721-x6f26ahr 1801 29 , , , cord-028721-x6f26ahr 1801 30 Denys Denys NNP cord-028721-x6f26ahr 1801 31 - - HYPH cord-028721-x6f26ahr 1801 32 Drash Drash NNP cord-028721-x6f26ahr 1801 33 , , , cord-028721-x6f26ahr 1801 34 WAGR WAGR NNP cord-028721-x6f26ahr 1801 35 , , , cord-028721-x6f26ahr 1801 36 Opiz Opiz NNP cord-028721-x6f26ahr 1801 37 , , , cord-028721-x6f26ahr 1801 38 camptomelic camptomelic JJ cord-028721-x6f26ahr 1801 39 dysplasia dysplasia NN cord-028721-x6f26ahr 1801 40 , , , cord-028721-x6f26ahr 1801 41 ATR ATR NNP cord-028721-x6f26ahr 1801 42 - - HYPH cord-028721-x6f26ahr 1801 43 X X NNP cord-028721-x6f26ahr 1801 44 , , , cord-028721-x6f26ahr 1801 45 Gardner Gardner NNP cord-028721-x6f26ahr 1801 46 - - HYPH cord-028721-x6f26ahr 1801 47 Silengo Silengo NNP cord-028721-x6f26ahr 1801 48 - - HYPH cord-028721-x6f26ahr 1801 49 Wachtel Wachtel NNP cord-028721-x6f26ahr 1801 50 , , , cord-028721-x6f26ahr 1801 51 Meckel Meckel NNP cord-028721-x6f26ahr 1801 52 , , , cord-028721-x6f26ahr 1801 53 branchioskeletal branchioskeletal JJ cord-028721-x6f26ahr 1801 54 - - HYPH cord-028721-x6f26ahr 1801 55 genital genital JJ cord-028721-x6f26ahr 1801 56 , , , cord-028721-x6f26ahr 1801 57 Down Down NNP cord-028721-x6f26ahr 1801 58 's 's POS cord-028721-x6f26ahr 1801 59 , , , cord-028721-x6f26ahr 1801 60 and and CC cord-028721-x6f26ahr 1801 61 other other JJ cord-028721-x6f26ahr 1801 62 trisomies trisomy NNS cord-028721-x6f26ahr 1801 63 . . . cord-028721-x6f26ahr 1802 1 RSH RSH NNP cord-028721-x6f26ahr 1802 2 ( ( -LRB- cord-028721-x6f26ahr 1802 3 Smith Smith NNP cord-028721-x6f26ahr 1802 4 - - HYPH cord-028721-x6f26ahr 1802 5 Lemli Lemli NNP cord-028721-x6f26ahr 1802 6 - - HYPH cord-028721-x6f26ahr 1802 7 Opitz Opitz NNP cord-028721-x6f26ahr 1802 8 ) ) -RRB- cord-028721-x6f26ahr 1802 9 syndrome syndrome NN cord-028721-x6f26ahr 1802 10 is be VBZ cord-028721-x6f26ahr 1802 11 a a DT cord-028721-x6f26ahr 1802 12 malformative malformative JJ cord-028721-x6f26ahr 1802 13 recessive recessive JJ cord-028721-x6f26ahr 1802 14 autosomal autosomal JJ cord-028721-x6f26ahr 1802 15 syndrome syndrome NN cord-028721-x6f26ahr 1802 16 caused cause VBN cord-028721-x6f26ahr 1802 17 by by IN cord-028721-x6f26ahr 1802 18 mutations mutation NNS cord-028721-x6f26ahr 1802 19 in in IN cord-028721-x6f26ahr 1802 20 the the DT cord-028721-x6f26ahr 1802 21 gene gene NN cord-028721-x6f26ahr 1802 22 encoding encoding NN cord-028721-x6f26ahr 1802 23 for for IN cord-028721-x6f26ahr 1802 24 7-dehydrocholesterol 7-dehydrocholesterol CD cord-028721-x6f26ahr 1802 25 reductase reductase NN cord-028721-x6f26ahr 1802 26 ( ( -LRB- cord-028721-x6f26ahr 1802 27 DHCR7 DHCR7 NNP cord-028721-x6f26ahr 1802 28 ) ) -RRB- cord-028721-x6f26ahr 1802 29 , , , cord-028721-x6f26ahr 1802 30 responsible responsible JJ cord-028721-x6f26ahr 1802 31 for for IN cord-028721-x6f26ahr 1802 32 the the DT cord-028721-x6f26ahr 1802 33 synthesis synthesis NN cord-028721-x6f26ahr 1802 34 of of IN cord-028721-x6f26ahr 1802 35 cholesterol cholesterol NN cord-028721-x6f26ahr 1802 36 from from IN cord-028721-x6f26ahr 1802 37 its -PRON- PRP$ cord-028721-x6f26ahr 1802 38 immediate immediate JJ cord-028721-x6f26ahr 1802 39 precursor precursor NN cord-028721-x6f26ahr 1802 40 7-dehydrocholesterol 7-dehydrocholesterol CD cord-028721-x6f26ahr 1802 41 . . . cord-028721-x6f26ahr 1803 1 [ [ -LRB- cord-028721-x6f26ahr 1803 2 814 814 CD cord-028721-x6f26ahr 1803 3 ] ] -RRB- cord-028721-x6f26ahr 1803 4 [ [ -LRB- cord-028721-x6f26ahr 1803 5 815 815 CD cord-028721-x6f26ahr 1803 6 ] ] -RRB- cord-028721-x6f26ahr 1803 7 [ [ -LRB- cord-028721-x6f26ahr 1803 8 816 816 CD cord-028721-x6f26ahr 1803 9 ] ] -RRB- cord-028721-x6f26ahr 1804 1 The the DT cord-028721-x6f26ahr 1804 2 disorder disorder NN cord-028721-x6f26ahr 1804 3 is be VBZ cord-028721-x6f26ahr 1804 4 common common JJ cord-028721-x6f26ahr 1804 5 in in IN cord-028721-x6f26ahr 1804 6 Europe Europe NNP cord-028721-x6f26ahr 1804 7 and and CC cord-028721-x6f26ahr 1804 8 rare rare JJ cord-028721-x6f26ahr 1804 9 in in IN cord-028721-x6f26ahr 1804 10 other other JJ cord-028721-x6f26ahr 1804 11 countries country NNS cord-028721-x6f26ahr 1804 12 . . . cord-028721-x6f26ahr 1805 1 817 817 CD cord-028721-x6f26ahr 1805 2 The the DT cord-028721-x6f26ahr 1805 3 most most RBS cord-028721-x6f26ahr 1805 4 severe severe JJ cord-028721-x6f26ahr 1805 5 form form NN cord-028721-x6f26ahr 1805 6 is be VBZ cord-028721-x6f26ahr 1805 7 lethal lethal JJ cord-028721-x6f26ahr 1805 8 before before IN cord-028721-x6f26ahr 1805 9 birth birth NN cord-028721-x6f26ahr 1805 10 . . . cord-028721-x6f26ahr 1806 1 Fetuses fetus NNS cord-028721-x6f26ahr 1806 2 show show VBP cord-028721-x6f26ahr 1806 3 postaxial postaxial NNP cord-028721-x6f26ahr 1806 4 oligodactyly oligodactyly NNP cord-028721-x6f26ahr 1806 5 ( ( -LRB- cord-028721-x6f26ahr 1806 6 instead instead RB cord-028721-x6f26ahr 1806 7 of of IN cord-028721-x6f26ahr 1806 8 polydactyly polydactyly NNP cord-028721-x6f26ahr 1806 9 ) ) -RRB- cord-028721-x6f26ahr 1806 10 and and CC cord-028721-x6f26ahr 1806 11 sometimes sometimes RB cord-028721-x6f26ahr 1806 12 severe severe JJ cord-028721-x6f26ahr 1806 13 hydrops hydrop NNS cord-028721-x6f26ahr 1806 14 . . . cord-028721-x6f26ahr 1807 1 818 818 CD cord-028721-x6f26ahr 1807 2 Non non JJ cord-028721-x6f26ahr 1807 3 - - JJ cord-028721-x6f26ahr 1807 4 lethal lethal JJ cord-028721-x6f26ahr 1807 5 forms form NNS cord-028721-x6f26ahr 1807 6 are be VBP cord-028721-x6f26ahr 1807 7 characterized characterize VBN cord-028721-x6f26ahr 1807 8 after after IN cord-028721-x6f26ahr 1807 9 birth birth NN cord-028721-x6f26ahr 1807 10 by by IN cord-028721-x6f26ahr 1807 11 severe severe JJ cord-028721-x6f26ahr 1807 12 growth growth NN cord-028721-x6f26ahr 1807 13 failure failure NN cord-028721-x6f26ahr 1807 14 ; ; : cord-028721-x6f26ahr 1807 15 a a DT cord-028721-x6f26ahr 1807 16 semi semi JJ cord-028721-x6f26ahr 1807 17 - - JJ cord-028721-x6f26ahr 1807 18 obtunded obtunded JJ cord-028721-x6f26ahr 1807 19 state state NN cord-028721-x6f26ahr 1807 20 ; ; , cord-028721-x6f26ahr 1807 21 absence absence NN cord-028721-x6f26ahr 1807 22 of of IN cord-028721-x6f26ahr 1807 23 psychomotor psychomotor JJ cord-028721-x6f26ahr 1807 24 development development NN cord-028721-x6f26ahr 1807 25 ; ; : cord-028721-x6f26ahr 1807 26 microcephaly microcephaly NNS cord-028721-x6f26ahr 1807 27 ; ; : cord-028721-x6f26ahr 1807 28 congenital congenital JJ cord-028721-x6f26ahr 1807 29 cataracts cataract NNS cord-028721-x6f26ahr 1807 30 ; ; : cord-028721-x6f26ahr 1807 31 peculiar peculiar JJ cord-028721-x6f26ahr 1807 32 facies facie NNS cord-028721-x6f26ahr 1807 33 ; ; : cord-028721-x6f26ahr 1807 34 broad broad RB cord-028721-x6f26ahr 1807 35 anteriorly anteriorly RB cord-028721-x6f26ahr 1807 36 rugose rugose JJ cord-028721-x6f26ahr 1807 37 alveolar alveolar JJ cord-028721-x6f26ahr 1807 38 ridges ridge NNS cord-028721-x6f26ahr 1807 39 with with IN cord-028721-x6f26ahr 1807 40 cleft cleft NN cord-028721-x6f26ahr 1807 41 palate palate NN cord-028721-x6f26ahr 1807 42 , , , cord-028721-x6f26ahr 1807 43 edema edema NN cord-028721-x6f26ahr 1807 44 of of IN cord-028721-x6f26ahr 1807 45 the the DT cord-028721-x6f26ahr 1807 46 nape nape NN cord-028721-x6f26ahr 1807 47 of of IN cord-028721-x6f26ahr 1807 48 the the DT cord-028721-x6f26ahr 1807 49 neck neck NN cord-028721-x6f26ahr 1807 50 , , , cord-028721-x6f26ahr 1807 51 and and CC cord-028721-x6f26ahr 1807 52 unilobulate unilobulate JJ cord-028721-x6f26ahr 1807 53 lungs lung NNS cord-028721-x6f26ahr 1807 54 ; ; : cord-028721-x6f26ahr 1807 55 male male JJ cord-028721-x6f26ahr 1807 56 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1807 57 or or CC cord-028721-x6f26ahr 1807 58 female female JJ cord-028721-x6f26ahr 1807 59 external external JJ cord-028721-x6f26ahr 1807 60 genitalia genitalia NNS cord-028721-x6f26ahr 1807 61 in in IN cord-028721-x6f26ahr 1807 62 46,XY 46,xy CD cord-028721-x6f26ahr 1807 63 patients patient NNS cord-028721-x6f26ahr 1807 64 ; ; : cord-028721-x6f26ahr 1807 65 postaxial postaxial JJ cord-028721-x6f26ahr 1807 66 polydactyly polydactyly NNS cord-028721-x6f26ahr 1807 67 of of IN cord-028721-x6f26ahr 1807 68 the the DT cord-028721-x6f26ahr 1807 69 hands hand NNS cord-028721-x6f26ahr 1807 70 and and CC cord-028721-x6f26ahr 1807 71 feet foot NNS cord-028721-x6f26ahr 1807 72 ; ; : cord-028721-x6f26ahr 1807 73 congenital congenital JJ cord-028721-x6f26ahr 1807 74 heart heart NN cord-028721-x6f26ahr 1807 75 defects defect NNS cord-028721-x6f26ahr 1807 76 ; ; , cord-028721-x6f26ahr 1807 77 and and CC cord-028721-x6f26ahr 1807 78 renal renal JJ cord-028721-x6f26ahr 1807 79 anomalies anomaly NNS cord-028721-x6f26ahr 1807 80 . . . cord-028721-x6f26ahr 1808 1 819 819 CD cord-028721-x6f26ahr 1808 2 Hepatic hepatic JJ cord-028721-x6f26ahr 1808 3 and and CC cord-028721-x6f26ahr 1808 4 renal renal JJ cord-028721-x6f26ahr 1808 5 insuffi insuffi NN cord-028721-x6f26ahr 1808 6 ciencies ciencie NNS cord-028721-x6f26ahr 1808 7 are be VBP cord-028721-x6f26ahr 1808 8 frequent frequent JJ cord-028721-x6f26ahr 1808 9 . . . cord-028721-x6f26ahr 1809 1 820 820 CD cord-028721-x6f26ahr 1810 1 The the DT cord-028721-x6f26ahr 1810 2 less less RBR cord-028721-x6f26ahr 1810 3 severe severe JJ cord-028721-x6f26ahr 1810 4 forms form NNS cord-028721-x6f26ahr 1810 5 in in IN cord-028721-x6f26ahr 1810 6 the the DT cord-028721-x6f26ahr 1810 7 male male NN cord-028721-x6f26ahr 1810 8 have have VBP cord-028721-x6f26ahr 1810 9 genital genital JJ cord-028721-x6f26ahr 1810 10 anomalies anomaly NNS cord-028721-x6f26ahr 1810 11 ( ( -LRB- cord-028721-x6f26ahr 1810 12 70 70 CD cord-028721-x6f26ahr 1810 13 % % NN cord-028721-x6f26ahr 1810 14 ) ) -RRB- cord-028721-x6f26ahr 1810 15 varying vary VBG cord-028721-x6f26ahr 1810 16 from from IN cord-028721-x6f26ahr 1810 17 normal normal JJ cord-028721-x6f26ahr 1810 18 genitalia genitalia NNS cord-028721-x6f26ahr 1810 19 to to IN cord-028721-x6f26ahr 1810 20 severe severe JJ cord-028721-x6f26ahr 1810 21 hypospadias hypospadia NNS cord-028721-x6f26ahr 1810 22 with with IN cord-028721-x6f26ahr 1810 23 or or CC cord-028721-x6f26ahr 1810 24 without without IN cord-028721-x6f26ahr 1810 25 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 1810 26 , , , cord-028721-x6f26ahr 1810 27 and and CC cord-028721-x6f26ahr 1810 28 numerous numerous JJ cord-028721-x6f26ahr 1810 29 small small JJ cord-028721-x6f26ahr 1810 30 anomalies anomaly NNS cord-028721-x6f26ahr 1810 31 whose whose WP$ cord-028721-x6f26ahr 1810 32 collection collection NN cord-028721-x6f26ahr 1810 33 characterizes characterize VBZ cord-028721-x6f26ahr 1810 34 the the DT cord-028721-x6f26ahr 1810 35 syndrome syndrome NN cord-028721-x6f26ahr 1810 36 . . . cord-028721-x6f26ahr 1811 1 Most Most JJS cord-028721-x6f26ahr 1811 2 patients patient NNS cord-028721-x6f26ahr 1811 3 also also RB cord-028721-x6f26ahr 1811 4 show show VBP cord-028721-x6f26ahr 1811 5 mental mental JJ cord-028721-x6f26ahr 1811 6 retardation retardation NN cord-028721-x6f26ahr 1811 7 and and CC cord-028721-x6f26ahr 1811 8 severe severe JJ cord-028721-x6f26ahr 1811 9 behavioral behavioral JJ cord-028721-x6f26ahr 1811 10 problems problem NNS cord-028721-x6f26ahr 1811 11 . . . cord-028721-x6f26ahr 1812 1 821 821 CD cord-028721-x6f26ahr 1813 1 The the DT cord-028721-x6f26ahr 1813 2 DHCR7 dhcr7 NN cord-028721-x6f26ahr 1813 3 gene gene NN cord-028721-x6f26ahr 1813 4 maps map NNS cord-028721-x6f26ahr 1813 5 to to IN cord-028721-x6f26ahr 1813 6 chromosome chromosome NN cord-028721-x6f26ahr 1814 1 11q12 11q12 CD cord-028721-x6f26ahr 1814 2 - - SYM cord-028721-x6f26ahr 1814 3 13 13 CD cord-028721-x6f26ahr 1814 4 . . . cord-028721-x6f26ahr 1815 1 Its -PRON- PRP$ cord-028721-x6f26ahr 1815 2 product product NN cord-028721-x6f26ahr 1815 3 is be VBZ cord-028721-x6f26ahr 1815 4 a a DT cord-028721-x6f26ahr 1815 5 microsomal microsomal NN cord-028721-x6f26ahr 1815 6 , , , cord-028721-x6f26ahr 1815 7 membrane membrane NN cord-028721-x6f26ahr 1815 8 - - HYPH cord-028721-x6f26ahr 1815 9 bound bind VBN cord-028721-x6f26ahr 1815 10 protein protein NN cord-028721-x6f26ahr 1815 11 . . . cord-028721-x6f26ahr 1816 1 Many many JJ cord-028721-x6f26ahr 1816 2 different different JJ cord-028721-x6f26ahr 1816 3 missense missense NN cord-028721-x6f26ahr 1816 4 , , , cord-028721-x6f26ahr 1816 5 nonsense nonsense NN cord-028721-x6f26ahr 1816 6 , , , cord-028721-x6f26ahr 1816 7 and and CC cord-028721-x6f26ahr 1816 8 splice splice NN cord-028721-x6f26ahr 1816 9 - - HYPH cord-028721-x6f26ahr 1816 10 site site NN cord-028721-x6f26ahr 1816 11 mutations mutation NNS cord-028721-x6f26ahr 1816 12 as as RB cord-028721-x6f26ahr 1816 13 well well RB cord-028721-x6f26ahr 1816 14 as as IN cord-028721-x6f26ahr 1816 15 duplications duplication NNS cord-028721-x6f26ahr 1816 16 and and CC cord-028721-x6f26ahr 1816 17 deletions deletion NNS cord-028721-x6f26ahr 1816 18 have have VBP cord-028721-x6f26ahr 1816 19 been be VBN cord-028721-x6f26ahr 1816 20 reported report VBN cord-028721-x6f26ahr 1816 21 . . . cord-028721-x6f26ahr 1817 1 [ [ -LRB- cord-028721-x6f26ahr 1817 2 822 822 CD cord-028721-x6f26ahr 1817 3 ] ] -RRB- cord-028721-x6f26ahr 1817 4 [ [ -LRB- cord-028721-x6f26ahr 1817 5 823 823 CD cord-028721-x6f26ahr 1817 6 ] ] -RRB- cord-028721-x6f26ahr 1818 1 [ [ -LRB- cord-028721-x6f26ahr 1818 2 824 824 CD cord-028721-x6f26ahr 1818 3 ] ] -RRB- cord-028721-x6f26ahr 1819 1 [ [ -LRB- cord-028721-x6f26ahr 1819 2 825 825 CD cord-028721-x6f26ahr 1819 3 ] ] -RRB- cord-028721-x6f26ahr 1819 4 [ [ -LRB- cord-028721-x6f26ahr 1819 5 826 826 CD cord-028721-x6f26ahr 1819 6 ] ] -RRB- cord-028721-x6f26ahr 1820 1 [ [ -LRB- cord-028721-x6f26ahr 1820 2 827 827 CD cord-028721-x6f26ahr 1820 3 ] ] -RRB- cord-028721-x6f26ahr 1821 1 Prenatal prenatal JJ cord-028721-x6f26ahr 1821 2 diagnosis diagnosis NN cord-028721-x6f26ahr 1821 3 is be VBZ cord-028721-x6f26ahr 1821 4 possible possible JJ cord-028721-x6f26ahr 1821 5 by by IN cord-028721-x6f26ahr 1821 6 relating relate VBG cord-028721-x6f26ahr 1821 7 ultrasound ultrasound NN cord-028721-x6f26ahr 1821 8 and and CC cord-028721-x6f26ahr 1821 9 cytogenetic cytogenetic JJ cord-028721-x6f26ahr 1821 10 studies study NNS cord-028721-x6f26ahr 1821 11 and and CC cord-028721-x6f26ahr 1821 12 carrying carry VBG cord-028721-x6f26ahr 1821 13 out out RP cord-028721-x6f26ahr 1821 14 a a DT cord-028721-x6f26ahr 1821 15 biochemical biochemical JJ cord-028721-x6f26ahr 1821 16 analysis analysis NN cord-028721-x6f26ahr 1821 17 in in IN cord-028721-x6f26ahr 1821 18 the the DT cord-028721-x6f26ahr 1821 19 second second JJ cord-028721-x6f26ahr 1821 20 trimester trimester NN cord-028721-x6f26ahr 1821 21 in in IN cord-028721-x6f26ahr 1821 22 those those DT cord-028721-x6f26ahr 1821 23 pregnant pregnant JJ cord-028721-x6f26ahr 1821 24 women woman NNS cord-028721-x6f26ahr 1821 25 who who WP cord-028721-x6f26ahr 1821 26 have have VBP cord-028721-x6f26ahr 1821 27 low low JJ cord-028721-x6f26ahr 1821 28 levels level NNS cord-028721-x6f26ahr 1821 29 or or CC cord-028721-x6f26ahr 1821 30 no no DT cord-028721-x6f26ahr 1821 31 conjugated conjugate VBN cord-028721-x6f26ahr 1821 32 estriol estriol NN cord-028721-x6f26ahr 1821 33 . . . cord-028721-x6f26ahr 1822 1 828 828 CD cord-028721-x6f26ahr 1823 1 In in IN cord-028721-x6f26ahr 1823 2 Denys Denys NNP cord-028721-x6f26ahr 1823 3 - - HYPH cord-028721-x6f26ahr 1823 4 Drash Drash NNP cord-028721-x6f26ahr 1823 5 syndrome syndrome NN cord-028721-x6f26ahr 1823 6 , , , cord-028721-x6f26ahr 1823 7 male male JJ cord-028721-x6f26ahr 1823 8 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1823 9 is be VBZ cord-028721-x6f26ahr 1823 10 associated associate VBN cord-028721-x6f26ahr 1823 11 with with IN cord-028721-x6f26ahr 1823 12 nephroblastoma nephroblastoma NNS cord-028721-x6f26ahr 1823 13 and and CC cord-028721-x6f26ahr 1823 14 renal renal JJ cord-028721-x6f26ahr 1823 15 insufficiency insufficiency NN cord-028721-x6f26ahr 1823 16 . . . cord-028721-x6f26ahr 1824 1 829 829 CD cord-028721-x6f26ahr 1825 1 The the DT cord-028721-x6f26ahr 1825 2 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1825 3 is be VBZ cord-028721-x6f26ahr 1825 4 usually usually RB cord-028721-x6f26ahr 1825 5 either either CC cord-028721-x6f26ahr 1825 6 mixed mixed JJ cord-028721-x6f26ahr 1825 7 gonadal gonadal JJ cord-028721-x6f26ahr 1825 8 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1825 9 , , , cord-028721-x6f26ahr 1825 10 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1825 11 male male JJ cord-028721-x6f26ahr 1825 12 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 1825 13 , , , cord-028721-x6f26ahr 1825 14 46XY 46xy CD cord-028721-x6f26ahr 1825 15 pure pure JJ cord-028721-x6f26ahr 1825 16 gonadal gonadal JJ cord-028721-x6f26ahr 1825 17 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1825 18 , , , cord-028721-x6f26ahr 1825 19 or or CC cord-028721-x6f26ahr 1825 20 true true JJ cord-028721-x6f26ahr 1825 21 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 1825 22 . . . cord-028721-x6f26ahr 1826 1 830 830 CD cord-028721-x6f26ahr 1827 1 The the DT cord-028721-x6f26ahr 1827 2 most most RBS cord-028721-x6f26ahr 1827 3 common common JJ cord-028721-x6f26ahr 1827 4 nephropathy nephropathy NN cord-028721-x6f26ahr 1827 5 is be VBZ cord-028721-x6f26ahr 1827 6 diffuse diffuse JJ cord-028721-x6f26ahr 1827 7 mesangial mesangial JJ cord-028721-x6f26ahr 1827 8 sclerosis sclerosis NN cord-028721-x6f26ahr 1827 9 . . . cord-028721-x6f26ahr 1828 1 831 831 CD cord-028721-x6f26ahr 1829 1 Most Most JJS cord-028721-x6f26ahr 1829 2 patients patient NNS cord-028721-x6f26ahr 1829 3 have have VBP cord-028721-x6f26ahr 1829 4 mutations mutation NNS cord-028721-x6f26ahr 1829 5 in in IN cord-028721-x6f26ahr 1829 6 the the DT cord-028721-x6f26ahr 1829 7 WT-1 WT-1 NNP cord-028721-x6f26ahr 1829 8 gene gene NN cord-028721-x6f26ahr 1829 9 , , , cord-028721-x6f26ahr 1829 10 832 832 CD cord-028721-x6f26ahr 1829 11 which which WDT cord-028721-x6f26ahr 1829 12 is be VBZ cord-028721-x6f26ahr 1829 13 expressed express VBN cord-028721-x6f26ahr 1829 14 in in IN cord-028721-x6f26ahr 1829 15 the the DT cord-028721-x6f26ahr 1829 16 genital genital JJ cord-028721-x6f26ahr 1829 17 ridge ridge NN cord-028721-x6f26ahr 1829 18 in in IN cord-028721-x6f26ahr 1829 19 the the DT cord-028721-x6f26ahr 1829 20 sixth sixth JJ cord-028721-x6f26ahr 1829 21 week week NN cord-028721-x6f26ahr 1829 22 of of IN cord-028721-x6f26ahr 1829 23 gestation gestation NN cord-028721-x6f26ahr 1829 24 and and CC cord-028721-x6f26ahr 1829 25 gives give VBZ cord-028721-x6f26ahr 1829 26 rise rise NN cord-028721-x6f26ahr 1829 27 to to IN cord-028721-x6f26ahr 1829 28 either either CC cord-028721-x6f26ahr 1829 29 streak streak NN cord-028721-x6f26ahr 1829 30 gonads gonad NNS cord-028721-x6f26ahr 1829 31 or or CC cord-028721-x6f26ahr 1829 32 testicular testicular NN cord-028721-x6f26ahr 1829 33 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1829 34 , , , cord-028721-x6f26ahr 1829 35 but but CC cord-028721-x6f26ahr 1829 36 , , , cord-028721-x6f26ahr 1829 37 if if IN cord-028721-x6f26ahr 1829 38 a a DT cord-028721-x6f26ahr 1829 39 delay delay NN cord-028721-x6f26ahr 1829 40 in in IN cord-028721-x6f26ahr 1829 41 testicular testicular JJ cord-028721-x6f26ahr 1829 42 determination determination NN cord-028721-x6f26ahr 1829 43 occurs occur VBZ cord-028721-x6f26ahr 1829 44 , , , cord-028721-x6f26ahr 1829 45 normal normal JJ cord-028721-x6f26ahr 1829 46 testes testis NNS cord-028721-x6f26ahr 1829 47 are be VBP cord-028721-x6f26ahr 1829 48 formed form VBN cord-028721-x6f26ahr 1829 49 . . . cord-028721-x6f26ahr 1830 1 833 833 CD cord-028721-x6f26ahr 1831 1 The the DT cord-028721-x6f26ahr 1831 2 term term NN cord-028721-x6f26ahr 1831 3 WAGR WAGR NNP cord-028721-x6f26ahr 1831 4 syndrome syndrome NN cord-028721-x6f26ahr 1831 5 refers refer VBZ cord-028721-x6f26ahr 1831 6 to to IN cord-028721-x6f26ahr 1831 7 Wilms Wilms NNP cord-028721-x6f26ahr 1831 8 ' ' POS cord-028721-x6f26ahr 1831 9 tumor tumor NN cord-028721-x6f26ahr 1831 10 , , , cord-028721-x6f26ahr 1831 11 aniridia aniridia NNP cord-028721-x6f26ahr 1831 12 , , , cord-028721-x6f26ahr 1831 13 genital genital JJ cord-028721-x6f26ahr 1831 14 anomalies anomaly NNS cord-028721-x6f26ahr 1831 15 , , , cord-028721-x6f26ahr 1831 16 and and CC cord-028721-x6f26ahr 1831 17 mental mental JJ cord-028721-x6f26ahr 1831 18 retardation retardation NN cord-028721-x6f26ahr 1831 19 . . . cord-028721-x6f26ahr 1832 1 Prevalence prevalence NN cord-028721-x6f26ahr 1832 2 is be VBZ cord-028721-x6f26ahr 1832 3 estimated estimate VBN cord-028721-x6f26ahr 1832 4 at at IN cord-028721-x6f26ahr 1832 5 between between IN cord-028721-x6f26ahr 1832 6 0.75 0.75 CD cord-028721-x6f26ahr 1832 7 % % NN cord-028721-x6f26ahr 1832 8 and and CC cord-028721-x6f26ahr 1832 9 2 2 CD cord-028721-x6f26ahr 1832 10 % % NN cord-028721-x6f26ahr 1832 11 of of IN cord-028721-x6f26ahr 1832 12 Wilms Wilms NNP cord-028721-x6f26ahr 1832 13 ' ' POS cord-028721-x6f26ahr 1832 14 tumor tumor NN cord-028721-x6f26ahr 1832 15 patients patient NNS cord-028721-x6f26ahr 1832 16 . . . cord-028721-x6f26ahr 1833 1 The the DT cord-028721-x6f26ahr 1833 2 syndrome syndrome NN cord-028721-x6f26ahr 1833 3 is be VBZ cord-028721-x6f26ahr 1833 4 related relate VBN cord-028721-x6f26ahr 1833 5 to to IN cord-028721-x6f26ahr 1833 6 the the DT cord-028721-x6f26ahr 1833 7 syndrome syndrome NN cord-028721-x6f26ahr 1833 8 of of IN cord-028721-x6f26ahr 1833 9 Denys Denys NNP cord-028721-x6f26ahr 1833 10 - - HYPH cord-028721-x6f26ahr 1833 11 Drash Drash NNP cord-028721-x6f26ahr 1833 12 and and CC cord-028721-x6f26ahr 1833 13 that that DT cord-028721-x6f26ahr 1833 14 of of IN cord-028721-x6f26ahr 1833 15 Frasier Frasier NNP cord-028721-x6f26ahr 1833 16 ( ( -LRB- cord-028721-x6f26ahr 1833 17 a a DT cord-028721-x6f26ahr 1833 18 variety variety NN cord-028721-x6f26ahr 1833 19 of of IN cord-028721-x6f26ahr 1833 20 46,XY 46,xy CD cord-028721-x6f26ahr 1833 21 gonadal gonadal JJ cord-028721-x6f26ahr 1833 22 dysgenesis dysgenesis NN cord-028721-x6f26ahr 1833 23 ) ) -RRB- cord-028721-x6f26ahr 1833 24 . . . cord-028721-x6f26ahr 1834 1 834 834 CD cord-028721-x6f26ahr 1834 2 , , , cord-028721-x6f26ahr 1834 3 835 835 CD cord-028721-x6f26ahr 1834 4 All all DT cord-028721-x6f26ahr 1834 5 have have VBP cord-028721-x6f26ahr 1834 6 in in IN cord-028721-x6f26ahr 1834 7 common common JJ cord-028721-x6f26ahr 1834 8 mutations mutation NNS cord-028721-x6f26ahr 1834 9 in in IN cord-028721-x6f26ahr 1834 10 the the DT cord-028721-x6f26ahr 1834 11 WT-1 WT-1 NNP cord-028721-x6f26ahr 1834 12 gene gene NN cord-028721-x6f26ahr 1834 13 located locate VBN cord-028721-x6f26ahr 1834 14 on on IN cord-028721-x6f26ahr 1834 15 chromosome chromosome NN cord-028721-x6f26ahr 1834 16 11 11 CD cord-028721-x6f26ahr 1834 17 ( ( -LRB- cord-028721-x6f26ahr 1834 18 11p13 11p13 CD cord-028721-x6f26ahr 1834 19 ) ) -RRB- cord-028721-x6f26ahr 1834 20 . . . cord-028721-x6f26ahr 1835 1 WT-1 WT-1 NNP cord-028721-x6f26ahr 1835 2 product product NN cord-028721-x6f26ahr 1835 3 is be VBZ cord-028721-x6f26ahr 1835 4 a a DT cord-028721-x6f26ahr 1835 5 transcription transcription NN cord-028721-x6f26ahr 1835 6 factor factor NN cord-028721-x6f26ahr 1835 7 expressed express VBN cord-028721-x6f26ahr 1835 8 in in IN cord-028721-x6f26ahr 1835 9 different different JJ cord-028721-x6f26ahr 1835 10 tissues tissue NNS cord-028721-x6f26ahr 1835 11 that that WDT cord-028721-x6f26ahr 1835 12 participates participate VBZ cord-028721-x6f26ahr 1835 13 in in IN cord-028721-x6f26ahr 1835 14 embryogenesis embryogenesis NN cord-028721-x6f26ahr 1835 15 and and CC cord-028721-x6f26ahr 1835 16 cell cell NN cord-028721-x6f26ahr 1835 17 differentiation differentiation NN cord-028721-x6f26ahr 1835 18 . . . cord-028721-x6f26ahr 1836 1 Mutations mutation NNS cord-028721-x6f26ahr 1836 2 lead lead VBP cord-028721-x6f26ahr 1836 3 to to IN cord-028721-x6f26ahr 1836 4 the the DT cord-028721-x6f26ahr 1836 5 production production NN cord-028721-x6f26ahr 1836 6 of of IN cord-028721-x6f26ahr 1836 7 an an DT cord-028721-x6f26ahr 1836 8 anomalous anomalous JJ cord-028721-x6f26ahr 1836 9 protein protein NN cord-028721-x6f26ahr 1836 10 that that WDT cord-028721-x6f26ahr 1836 11 causes cause VBZ cord-028721-x6f26ahr 1836 12 alterations alteration NNS cord-028721-x6f26ahr 1836 13 in in IN cord-028721-x6f26ahr 1836 14 renal renal JJ cord-028721-x6f26ahr 1836 15 function function NN cord-028721-x6f26ahr 1836 16 , , , cord-028721-x6f26ahr 1836 17 gonadal gonadal JJ cord-028721-x6f26ahr 1836 18 anomalies anomaly NNS cord-028721-x6f26ahr 1836 19 , , , cord-028721-x6f26ahr 1836 20 and and CC cord-028721-x6f26ahr 1836 21 the the DT cord-028721-x6f26ahr 1836 22 loss loss NN cord-028721-x6f26ahr 1836 23 of of IN cord-028721-x6f26ahr 1836 24 tumor tumor NN cord-028721-x6f26ahr 1836 25 suppressor suppressor NN cord-028721-x6f26ahr 1836 26 function function NN cord-028721-x6f26ahr 1836 27 . . . cord-028721-x6f26ahr 1837 1 Six six CD cord-028721-x6f26ahr 1837 2 variants variant NNS cord-028721-x6f26ahr 1837 3 of of IN cord-028721-x6f26ahr 1837 4 alleles allele NNS cord-028721-x6f26ahr 1837 5 have have VBP cord-028721-x6f26ahr 1837 6 been be VBN cord-028721-x6f26ahr 1837 7 described describe VBN cord-028721-x6f26ahr 1837 8 : : : cord-028721-x6f26ahr 1837 9 isolated isolate VBN cord-028721-x6f26ahr 1837 10 Wilms Wilms NNP cord-028721-x6f26ahr 1837 11 ' ' POS cord-028721-x6f26ahr 1837 12 tumor tumor NN cord-028721-x6f26ahr 1837 13 , , , cord-028721-x6f26ahr 1837 14 mesothelioma mesothelioma NN cord-028721-x6f26ahr 1837 15 , , , cord-028721-x6f26ahr 1837 16 isolated isolate VBN cord-028721-x6f26ahr 1837 17 diffuse diffuse JJ cord-028721-x6f26ahr 1837 18 mesangial mesangial JJ cord-028721-x6f26ahr 1837 19 sclerosis sclerosis NN cord-028721-x6f26ahr 1837 20 , , , cord-028721-x6f26ahr 1837 21 Denis Denis NNP cord-028721-x6f26ahr 1837 22 - - HYPH cord-028721-x6f26ahr 1837 23 Drash Drash NNP cord-028721-x6f26ahr 1837 24 syndrome syndrome NN cord-028721-x6f26ahr 1837 25 , , , cord-028721-x6f26ahr 1837 26 Frasier Frasier NNP cord-028721-x6f26ahr 1837 27 syndrome syndrome NN cord-028721-x6f26ahr 1837 28 , , , cord-028721-x6f26ahr 1837 29 and and CC cord-028721-x6f26ahr 1837 30 WAGR WAGR NNP cord-028721-x6f26ahr 1837 31 syndrome syndrome NN cord-028721-x6f26ahr 1837 32 . . . cord-028721-x6f26ahr 1838 1 Frasier Frasier NNP cord-028721-x6f26ahr 1838 2 syndrome syndrome NN cord-028721-x6f26ahr 1838 3 is be VBZ cord-028721-x6f26ahr 1838 4 caused cause VBN cord-028721-x6f26ahr 1838 5 by by IN cord-028721-x6f26ahr 1838 6 mutations mutation NNS cord-028721-x6f26ahr 1838 7 in in IN cord-028721-x6f26ahr 1838 8 the the DT cord-028721-x6f26ahr 1838 9 donor donor NN cord-028721-x6f26ahr 1838 10 zone zone NN cord-028721-x6f26ahr 1838 11 of of IN cord-028721-x6f26ahr 1838 12 the the DT cord-028721-x6f26ahr 1838 13 intron intron NN cord-028721-x6f26ahr 1838 14 9 9 CD cord-028721-x6f26ahr 1838 15 link link NN cord-028721-x6f26ahr 1838 16 , , , cord-028721-x6f26ahr 1838 17 with with IN cord-028721-x6f26ahr 1838 18 the the DT cord-028721-x6f26ahr 1838 19 subsequent subsequent JJ cord-028721-x6f26ahr 1838 20 loss loss NN cord-028721-x6f26ahr 1838 21 of of IN cord-028721-x6f26ahr 1838 22 the the DT cord-028721-x6f26ahr 1838 23 + + JJ cord-028721-x6f26ahr 1838 24 KTS KTS NNP cord-028721-x6f26ahr 1838 25 isoform isoform NN cord-028721-x6f26ahr 1838 26 ( ( -LRB- cord-028721-x6f26ahr 1838 27 the the DT cord-028721-x6f26ahr 1838 28 patient patient NN cord-028721-x6f26ahr 1838 29 has have VBZ cord-028721-x6f26ahr 1838 30 an an DT cord-028721-x6f26ahr 1838 31 imbalance imbalance NN cord-028721-x6f26ahr 1838 32 in in IN cord-028721-x6f26ahr 1838 33 KTS KTS NNP cord-028721-x6f26ahr 1838 34 isoforms isoform NNS cord-028721-x6f26ahr 1838 35 ) ) -RRB- cord-028721-x6f26ahr 1838 36 , , , cord-028721-x6f26ahr 1838 37 whereas whereas IN cord-028721-x6f26ahr 1838 38 large large JJ cord-028721-x6f26ahr 1838 39 deletions deletion NNS cord-028721-x6f26ahr 1838 40 or or CC cord-028721-x6f26ahr 1838 41 loss loss NN cord-028721-x6f26ahr 1838 42 of of IN cord-028721-x6f26ahr 1838 43 genetic genetic JJ cord-028721-x6f26ahr 1838 44 material material NN cord-028721-x6f26ahr 1838 45 that that WDT cord-028721-x6f26ahr 1838 46 comprises comprise VBZ cord-028721-x6f26ahr 1838 47 the the DT cord-028721-x6f26ahr 1838 48 WT-1 WT-1 NNP cord-028721-x6f26ahr 1838 49 gene gene NN cord-028721-x6f26ahr 1838 50 and and CC cord-028721-x6f26ahr 1838 51 other other JJ cord-028721-x6f26ahr 1838 52 contiguous contiguous JJ cord-028721-x6f26ahr 1838 53 genes gene NNS cord-028721-x6f26ahr 1838 54 ( ( -LRB- cord-028721-x6f26ahr 1838 55 PAX6 PAX6 NNP cord-028721-x6f26ahr 1838 56 or or CC cord-028721-x6f26ahr 1838 57 AN AN NNP cord-028721-x6f26ahr 1838 58 ) ) -RRB- cord-028721-x6f26ahr 1838 59 lead lead NN cord-028721-x6f26ahr 1838 60 to to IN cord-028721-x6f26ahr 1838 61 the the DT cord-028721-x6f26ahr 1838 62 WAGR WAGR NNP cord-028721-x6f26ahr 1838 63 syndrome syndrome NN cord-028721-x6f26ahr 1838 64 . . . cord-028721-x6f26ahr 1839 1 836 836 CD cord-028721-x6f26ahr 1839 2 , , , cord-028721-x6f26ahr 1839 3 837 837 CD cord-028721-x6f26ahr 1839 4 Patients patient NNS cord-028721-x6f26ahr 1839 5 with with IN cord-028721-x6f26ahr 1839 6 Opitz Opitz NNP cord-028721-x6f26ahr 1839 7 's 's POS cord-028721-x6f26ahr 1839 8 syndrome syndrome NN cord-028721-x6f26ahr 1839 9 are be VBP cord-028721-x6f26ahr 1839 10 mainly mainly RB cord-028721-x6f26ahr 1839 11 boys boy NNS cord-028721-x6f26ahr 1839 12 with with IN cord-028721-x6f26ahr 1839 13 hypertelorism hypertelorism NNP cord-028721-x6f26ahr 1839 14 and and CC cord-028721-x6f26ahr 1839 15 , , , cord-028721-x6f26ahr 1839 16 in in IN cord-028721-x6f26ahr 1839 17 the the DT cord-028721-x6f26ahr 1839 18 severe severe JJ cord-028721-x6f26ahr 1839 19 forms form NNS cord-028721-x6f26ahr 1839 20 , , , cord-028721-x6f26ahr 1839 21 unilateral unilateral JJ cord-028721-x6f26ahr 1839 22 or or CC cord-028721-x6f26ahr 1839 23 bilateral bilateral JJ cord-028721-x6f26ahr 1839 24 lip lip NN cord-028721-x6f26ahr 1839 25 cleft cleft NN cord-028721-x6f26ahr 1839 26 , , , cord-028721-x6f26ahr 1839 27 laryngeal laryngeal NN cord-028721-x6f26ahr 1839 28 cleft cleft NN cord-028721-x6f26ahr 1839 29 , , , cord-028721-x6f26ahr 1839 30 severe severe JJ cord-028721-x6f26ahr 1839 31 dysphagia dysphagia NN cord-028721-x6f26ahr 1839 32 with with IN cord-028721-x6f26ahr 1839 33 more more JJR cord-028721-x6f26ahr 1839 34 or or CC cord-028721-x6f26ahr 1839 35 less less JJR cord-028721-x6f26ahr 1839 36 life life NN cord-028721-x6f26ahr 1839 37 - - HYPH cord-028721-x6f26ahr 1839 38 threatening threaten VBG cord-028721-x6f26ahr 1839 39 aspiration aspiration NN cord-028721-x6f26ahr 1839 40 , , , cord-028721-x6f26ahr 1839 41 hypospadias hypospadia NNS cord-028721-x6f26ahr 1839 42 and and CC cord-028721-x6f26ahr 1839 43 , , , cord-028721-x6f26ahr 1839 44 occasionally occasionally RB cord-028721-x6f26ahr 1839 45 , , , cord-028721-x6f26ahr 1839 46 imperforate imperforate JJ cord-028721-x6f26ahr 1839 47 anus anus NN cord-028721-x6f26ahr 1839 48 . . . cord-028721-x6f26ahr 1840 1 The the DT cord-028721-x6f26ahr 1840 2 most most RBS cord-028721-x6f26ahr 1840 3 important important JJ cord-028721-x6f26ahr 1840 4 internal internal JJ cord-028721-x6f26ahr 1840 5 anomalies anomaly NNS cord-028721-x6f26ahr 1840 6 are be VBP cord-028721-x6f26ahr 1840 7 those those DT cord-028721-x6f26ahr 1840 8 in in IN cord-028721-x6f26ahr 1840 9 the the DT cord-028721-x6f26ahr 1840 10 tracheobronchial tracheobronchial JJ cord-028721-x6f26ahr 1840 11 tree tree NN cord-028721-x6f26ahr 1840 12 , , , cord-028721-x6f26ahr 1840 13 cardiovascular cardiovascular JJ cord-028721-x6f26ahr 1840 14 system system NN cord-028721-x6f26ahr 1840 15 ( ( -LRB- cord-028721-x6f26ahr 1840 16 defects defect NNS cord-028721-x6f26ahr 1840 17 in in IN cord-028721-x6f26ahr 1840 18 cardiac cardiac JJ cord-028721-x6f26ahr 1840 19 septation septation NN cord-028721-x6f26ahr 1840 20 ) ) -RRB- cord-028721-x6f26ahr 1840 21 , , , cord-028721-x6f26ahr 1840 22 and and CC cord-028721-x6f26ahr 1840 23 gallbladder gallbladder NN cord-028721-x6f26ahr 1840 24 , , , cord-028721-x6f26ahr 1840 25 with with IN cord-028721-x6f26ahr 1840 26 a a DT cord-028721-x6f26ahr 1840 27 subjacent subjacent JJ cord-028721-x6f26ahr 1840 28 defect defect NN cord-028721-x6f26ahr 1840 29 of of IN cord-028721-x6f26ahr 1840 30 the the DT cord-028721-x6f26ahr 1840 31 developing develop VBG cord-028721-x6f26ahr 1840 32 embryonal embryonal JJ cord-028721-x6f26ahr 1840 33 ventral ventral JJ cord-028721-x6f26ahr 1840 34 midline midline NN cord-028721-x6f26ahr 1840 35 . . . cord-028721-x6f26ahr 1841 1 The the DT cord-028721-x6f26ahr 1841 2 syndrome syndrome NN cord-028721-x6f26ahr 1841 3 is be VBZ cord-028721-x6f26ahr 1841 4 genetically genetically RB cord-028721-x6f26ahr 1841 5 heterogeneous heterogeneous JJ cord-028721-x6f26ahr 1841 6 and and CC cord-028721-x6f26ahr 1841 7 consists consist VBZ cord-028721-x6f26ahr 1841 8 of of IN cord-028721-x6f26ahr 1841 9 two two CD cord-028721-x6f26ahr 1841 10 entities entity NNS cord-028721-x6f26ahr 1841 11 that that WDT cord-028721-x6f26ahr 1841 12 were be VBD cord-028721-x6f26ahr 1841 13 described describe VBN cord-028721-x6f26ahr 1841 14 as as RB cord-028721-x6f26ahr 1841 15 different different JJ cord-028721-x6f26ahr 1841 16 in in IN cord-028721-x6f26ahr 1841 17 the the DT cord-028721-x6f26ahr 1841 18 past past NN cord-028721-x6f26ahr 1841 19 : : : cord-028721-x6f26ahr 1841 20 ADOS ADOS NNP cord-028721-x6f26ahr 1841 21 , , , cord-028721-x6f26ahr 1841 22 or or CC cord-028721-x6f26ahr 1841 23 autosomal autosomal JJ cord-028721-x6f26ahr 1841 24 dominant dominant JJ cord-028721-x6f26ahr 1841 25 Opitz Opitz NNP cord-028721-x6f26ahr 1841 26 syndrome syndrome NN cord-028721-x6f26ahr 1841 27 or or CC cord-028721-x6f26ahr 1841 28 G g NN cord-028721-x6f26ahr 1841 29 syn- syn- NN cord-028721-x6f26ahr 1841 30 drome drome NN cord-028721-x6f26ahr 1841 31 838 838 CD cord-028721-x6f26ahr 1841 32 with with IN cord-028721-x6f26ahr 1841 33 a a DT cord-028721-x6f26ahr 1841 34 mutated mutate VBN cord-028721-x6f26ahr 1841 35 gene gene NN cord-028721-x6f26ahr 1841 36 that that WDT cord-028721-x6f26ahr 1841 37 maps map VBZ cord-028721-x6f26ahr 1841 38 to to IN cord-028721-x6f26ahr 1841 39 22q11.2 22q11.2 CD cord-028721-x6f26ahr 1841 40 ; ; : cord-028721-x6f26ahr 1841 41 and and CC cord-028721-x6f26ahr 1841 42 XLOS XLOS NNP cord-028721-x6f26ahr 1841 43 , , , cord-028721-x6f26ahr 1841 44 or or CC cord-028721-x6f26ahr 1841 45 X X NNS cord-028721-x6f26ahr 1841 46 - - HYPH cord-028721-x6f26ahr 1841 47 linked link VBN cord-028721-x6f26ahr 1841 48 Opitz Opitz NNP cord-028721-x6f26ahr 1841 49 syndrome syndrome NN cord-028721-x6f26ahr 1841 50 or or CC cord-028721-x6f26ahr 1841 51 BBB BBB NNP cord-028721-x6f26ahr 1841 52 syndrome syndrome NN cord-028721-x6f26ahr 1841 53 839 839 CD cord-028721-x6f26ahr 1841 54 with with IN cord-028721-x6f26ahr 1841 55 a a DT cord-028721-x6f26ahr 1841 56 mutated mutate VBN cord-028721-x6f26ahr 1841 57 gene gene NN cord-028721-x6f26ahr 1841 58 that that WDT cord-028721-x6f26ahr 1841 59 maps map VBZ cord-028721-x6f26ahr 1841 60 to to IN cord-028721-x6f26ahr 1841 61 Xp22.3 Xp22.3 NNP cord-028721-x6f26ahr 1841 62 . . . cord-028721-x6f26ahr 1842 1 840 840 CD cord-028721-x6f26ahr 1842 2 , , , cord-028721-x6f26ahr 1842 3 841 841 CD cord-028721-x6f26ahr 1842 4 Camptomelic Camptomelic NNP cord-028721-x6f26ahr 1842 5 dysplasia dysplasia NN cord-028721-x6f26ahr 1842 6 is be VBZ cord-028721-x6f26ahr 1842 7 an an DT cord-028721-x6f26ahr 1842 8 autosomal autosomal JJ cord-028721-x6f26ahr 1842 9 dominant dominant JJ cord-028721-x6f26ahr 1842 10 syndrome syndrome NN cord-028721-x6f26ahr 1842 11 with with IN cord-028721-x6f26ahr 1842 12 multiple multiple JJ cord-028721-x6f26ahr 1842 13 osseous osseous JJ cord-028721-x6f26ahr 1842 14 malformations malformation NNS cord-028721-x6f26ahr 1842 15 . . . cord-028721-x6f26ahr 1843 1 Patients patient NNS cord-028721-x6f26ahr 1843 2 have have VBP cord-028721-x6f26ahr 1843 3 46XY 46xy CD cord-028721-x6f26ahr 1843 4 karyotype karyotype NN cord-028721-x6f26ahr 1843 5 and and CC cord-028721-x6f26ahr 1843 6 external external JJ cord-028721-x6f26ahr 1843 7 genitalia genitalia NNS cord-028721-x6f26ahr 1843 8 that that WDT cord-028721-x6f26ahr 1843 9 are be VBP cord-028721-x6f26ahr 1843 10 ambiguous ambiguous JJ cord-028721-x6f26ahr 1843 11 or or CC cord-028721-x6f26ahr 1843 12 female female JJ cord-028721-x6f26ahr 1843 13 . . . cord-028721-x6f26ahr 1844 1 Gonadal gonadal NN cord-028721-x6f26ahr 1844 2 histology histology NN cord-028721-x6f26ahr 1844 3 varies vary VBZ cord-028721-x6f26ahr 1844 4 from from IN cord-028721-x6f26ahr 1844 5 testes testis NNS cord-028721-x6f26ahr 1844 6 to to IN cord-028721-x6f26ahr 1844 7 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1844 8 ovaries ovary NNS cord-028721-x6f26ahr 1844 9 with with IN cord-028721-x6f26ahr 1844 10 primary primary JJ cord-028721-x6f26ahr 1844 11 follicles follicle NNS cord-028721-x6f26ahr 1844 12 . . . cord-028721-x6f26ahr 1845 1 The the DT cord-028721-x6f26ahr 1845 2 cause cause NN cord-028721-x6f26ahr 1845 3 is be VBZ cord-028721-x6f26ahr 1845 4 a a DT cord-028721-x6f26ahr 1845 5 haploinsufficiency haploinsufficiency NN cord-028721-x6f26ahr 1845 6 of of IN cord-028721-x6f26ahr 1845 7 SOX9 SOX9 NNP cord-028721-x6f26ahr 1845 8 , , , cord-028721-x6f26ahr 1845 9 located locate VBN cord-028721-x6f26ahr 1845 10 on on IN cord-028721-x6f26ahr 1845 11 17q 17q CD cord-028721-x6f26ahr 1845 12 . . . cord-028721-x6f26ahr 1846 1 842 842 CD cord-028721-x6f26ahr 1847 1 The the DT cord-028721-x6f26ahr 1847 2 incidence incidence NN cord-028721-x6f26ahr 1847 3 of of IN cord-028721-x6f26ahr 1847 4 gonadoblastoma gonadoblastoma NNP cord-028721-x6f26ahr 1847 5 is be VBZ cord-028721-x6f26ahr 1847 6 low low JJ cord-028721-x6f26ahr 1847 7 . . . cord-028721-x6f26ahr 1848 1 ATR ATR NNP cord-028721-x6f26ahr 1848 2 - - HYPH cord-028721-x6f26ahr 1848 3 X x NN cord-028721-x6f26ahr 1848 4 syndrome syndrome NN cord-028721-x6f26ahr 1848 5 is be VBZ cord-028721-x6f26ahr 1848 6 characterized characterize VBN cord-028721-x6f26ahr 1848 7 by by IN cord-028721-x6f26ahr 1848 8 mild mild JJ cord-028721-x6f26ahr 1848 9 α α NN cord-028721-x6f26ahr 1848 10 - - HYPH cord-028721-x6f26ahr 1848 11 thalassemia thalassemia NN cord-028721-x6f26ahr 1848 12 , , , cord-028721-x6f26ahr 1848 13 mental mental JJ cord-028721-x6f26ahr 1848 14 retardation retardation NN cord-028721-x6f26ahr 1848 15 , , , cord-028721-x6f26ahr 1848 16 facial facial JJ cord-028721-x6f26ahr 1848 17 dysmorphism dysmorphism NN cord-028721-x6f26ahr 1848 18 , , , cord-028721-x6f26ahr 1848 19 and and CC cord-028721-x6f26ahr 1848 20 hypospadias hypospadia NNS cord-028721-x6f26ahr 1848 21 . . . cord-028721-x6f26ahr 1849 1 843 843 CD cord-028721-x6f26ahr 1849 2 , , , cord-028721-x6f26ahr 1849 3 844 844 CD cord-028721-x6f26ahr 1850 1 The the DT cord-028721-x6f26ahr 1850 2 disorder disorder NN cord-028721-x6f26ahr 1850 3 is be VBZ cord-028721-x6f26ahr 1850 4 X x NN cord-028721-x6f26ahr 1850 5 - - VBN cord-028721-x6f26ahr 1850 6 linked link VBN cord-028721-x6f26ahr 1850 7 , , , cord-028721-x6f26ahr 1850 8 and and CC cord-028721-x6f26ahr 1850 9 is be VBZ cord-028721-x6f26ahr 1850 10 caused cause VBN cord-028721-x6f26ahr 1850 11 by by IN cord-028721-x6f26ahr 1850 12 mutation mutation NN cord-028721-x6f26ahr 1850 13 in in IN cord-028721-x6f26ahr 1850 14 the the DT cord-028721-x6f26ahr 1850 15 ART art NN cord-028721-x6f26ahr 1850 16 - - HYPH cord-028721-x6f26ahr 1850 17 X x NN cord-028721-x6f26ahr 1850 18 gene gene NN cord-028721-x6f26ahr 1850 19 ( ( -LRB- cord-028721-x6f26ahr 1850 20 synonymous synonymous JJ cord-028721-x6f26ahr 1850 21 XNP XNP NNP cord-028721-x6f26ahr 1850 22 , , , cord-028721-x6f26ahr 1850 23 HX2 HX2 NNP cord-028721-x6f26ahr 1850 24 ) ) -RRB- cord-028721-x6f26ahr 1850 25 . . . cord-028721-x6f26ahr 1851 1 845 845 CD cord-028721-x6f26ahr 1851 2 Testicular Testicular NNP cord-028721-x6f26ahr 1851 3 biopsy biopsy NN cord-028721-x6f26ahr 1851 4 to to TO cord-028721-x6f26ahr 1851 5 diagnose diagnose VB cord-028721-x6f26ahr 1851 6 infertility infertility NN cord-028721-x6f26ahr 1851 7 began begin VBD cord-028721-x6f26ahr 1851 8 in in IN cord-028721-x6f26ahr 1851 9 the the DT cord-028721-x6f26ahr 1851 10 1940s 1940 NNS cord-028721-x6f26ahr 1851 11 , , , cord-028721-x6f26ahr 1851 12 846 846 CD cord-028721-x6f26ahr 1851 13 , , , cord-028721-x6f26ahr 1851 14 847 847 CD cord-028721-x6f26ahr 1851 15 and and CC cord-028721-x6f26ahr 1851 16 most most JJS cord-028721-x6f26ahr 1851 17 of of IN cord-028721-x6f26ahr 1851 18 the the DT cord-028721-x6f26ahr 1851 19 diagnostic diagnostic JJ cord-028721-x6f26ahr 1851 20 terms term NNS cord-028721-x6f26ahr 1851 21 used use VBN cord-028721-x6f26ahr 1851 22 today today NN cord-028721-x6f26ahr 1851 23 were be VBD cord-028721-x6f26ahr 1851 24 created create VBN cord-028721-x6f26ahr 1851 25 then then RB cord-028721-x6f26ahr 1851 26 . . . cord-028721-x6f26ahr 1852 1 848 848 CD cord-028721-x6f26ahr 1853 1 These these DT cord-028721-x6f26ahr 1853 2 terms term NNS cord-028721-x6f26ahr 1853 3 are be VBP cord-028721-x6f26ahr 1853 4 usually usually RB cord-028721-x6f26ahr 1853 5 descriptive descriptive JJ cord-028721-x6f26ahr 1853 6 and and CC cord-028721-x6f26ahr 1853 7 , , , cord-028721-x6f26ahr 1853 8 except except IN cord-028721-x6f26ahr 1853 9 for for IN cord-028721-x6f26ahr 1853 10 a a DT cord-028721-x6f26ahr 1853 11 few few JJ cord-028721-x6f26ahr 1853 12 ( ( -LRB- cord-028721-x6f26ahr 1853 13 normal normal JJ cord-028721-x6f26ahr 1853 14 testes testis NNS cord-028721-x6f26ahr 1853 15 , , , cord-028721-x6f26ahr 1853 16 Sertoli sertoli JJ cord-028721-x6f26ahr 1853 17 cell cell NN cord-028721-x6f26ahr 1853 18 - - HYPH cord-028721-x6f26ahr 1853 19 only only RB cord-028721-x6f26ahr 1853 20 tubules tubule NNS cord-028721-x6f26ahr 1853 21 , , , cord-028721-x6f26ahr 1853 22 tubular tubular JJ cord-028721-x6f26ahr 1853 23 hyalinization hyalinization NN cord-028721-x6f26ahr 1853 24 , , , cord-028721-x6f26ahr 1853 25 for for IN cord-028721-x6f26ahr 1853 26 example example NN cord-028721-x6f26ahr 1853 27 ) ) -RRB- cord-028721-x6f26ahr 1853 28 , , , cord-028721-x6f26ahr 1853 29 do do VBP cord-028721-x6f26ahr 1853 30 not not RB cord-028721-x6f26ahr 1853 31 specify specify VB cord-028721-x6f26ahr 1853 32 the the DT cord-028721-x6f26ahr 1853 33 degree degree NN cord-028721-x6f26ahr 1853 34 of of IN cord-028721-x6f26ahr 1853 35 tubular tubular JJ cord-028721-x6f26ahr 1853 36 abnormality abnormality NN cord-028721-x6f26ahr 1853 37 that that WDT cord-028721-x6f26ahr 1853 38 is be VBZ cord-028721-x6f26ahr 1853 39 evaluated evaluate VBN cord-028721-x6f26ahr 1853 40 by by IN cord-028721-x6f26ahr 1853 41 each each DT cord-028721-x6f26ahr 1853 42 pathologist pathologist NN cord-028721-x6f26ahr 1853 43 subjectively subjectively RB cord-028721-x6f26ahr 1853 44 . . . cord-028721-x6f26ahr 1854 1 The the DT cord-028721-x6f26ahr 1854 2 terms term NNS cord-028721-x6f26ahr 1854 3 maturation maturation NN cord-028721-x6f26ahr 1854 4 arrest arrest NN cord-028721-x6f26ahr 1854 5 and and CC cord-028721-x6f26ahr 1854 6 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 1854 7 have have VBP cord-028721-x6f26ahr 1854 8 been be VBN cord-028721-x6f26ahr 1854 9 applied apply VBN cord-028721-x6f26ahr 1854 10 to to IN cord-028721-x6f26ahr 1854 11 biopsies biopsy NNS cord-028721-x6f26ahr 1854 12 in in IN cord-028721-x6f26ahr 1854 13 more more JJR cord-028721-x6f26ahr 1854 14 than than IN cord-028721-x6f26ahr 1854 15 50 50 CD cord-028721-x6f26ahr 1854 16 % % NN cord-028721-x6f26ahr 1854 17 of of IN cord-028721-x6f26ahr 1854 18 cases case NNS cord-028721-x6f26ahr 1854 19 of of IN cord-028721-x6f26ahr 1854 20 infertility infertility NN cord-028721-x6f26ahr 1854 21 , , , cord-028721-x6f26ahr 1854 22 849 849 CD cord-028721-x6f26ahr 1854 23 - - SYM cord-028721-x6f26ahr 1854 24 851 851 CD cord-028721-x6f26ahr 1854 25 but but CC cord-028721-x6f26ahr 1854 26 the the DT cord-028721-x6f26ahr 1854 27 criteria criterion NNS cord-028721-x6f26ahr 1854 28 for for IN cord-028721-x6f26ahr 1854 29 these these DT cord-028721-x6f26ahr 1854 30 vary vary VBP cord-028721-x6f26ahr 1854 31 widely widely RB cord-028721-x6f26ahr 1854 32 among among IN cord-028721-x6f26ahr 1854 33 pathologists pathologist NNS cord-028721-x6f26ahr 1854 34 . . . cord-028721-x6f26ahr 1855 1 Two two CD cord-028721-x6f26ahr 1855 2 forms form NNS cord-028721-x6f26ahr 1855 3 of of IN cord-028721-x6f26ahr 1855 4 maturation maturation NN cord-028721-x6f26ahr 1855 5 arrest arrest NN cord-028721-x6f26ahr 1855 6 have have VBP cord-028721-x6f26ahr 1855 7 been be VBN cord-028721-x6f26ahr 1855 8 described describe VBN cord-028721-x6f26ahr 1855 9 : : : cord-028721-x6f26ahr 1855 10 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 1855 11 arrest arrest NN cord-028721-x6f26ahr 1855 12 , , , cord-028721-x6f26ahr 1855 13 and and CC cord-028721-x6f26ahr 1855 14 spermatocytic spermatocytic JJ cord-028721-x6f26ahr 1855 15 arrest arrest NN cord-028721-x6f26ahr 1855 16 , , , cord-028721-x6f26ahr 1855 17 or or CC cord-028721-x6f26ahr 1855 18 its -PRON- PRP$ cord-028721-x6f26ahr 1855 19 equivalent equivalent JJ cord-028721-x6f26ahr 1855 20 , , , cord-028721-x6f26ahr 1855 21 meiotic meiotic JJ cord-028721-x6f26ahr 1855 22 arrest arrest NN cord-028721-x6f26ahr 1855 23 . . . cord-028721-x6f26ahr 1856 1 True true JJ cord-028721-x6f26ahr 1856 2 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 1856 3 arrest arrest NN cord-028721-x6f26ahr 1856 4 is be VBZ cord-028721-x6f26ahr 1856 5 rare rare JJ cord-028721-x6f26ahr 1856 6 because because IN cord-028721-x6f26ahr 1856 7 germ germ NN cord-028721-x6f26ahr 1856 8 cell cell NN cord-028721-x6f26ahr 1856 9 maturation maturation NN cord-028721-x6f26ahr 1856 10 usually usually RB cord-028721-x6f26ahr 1856 11 does do VBZ cord-028721-x6f26ahr 1856 12 not not RB cord-028721-x6f26ahr 1856 13 arrest arrest VB cord-028721-x6f26ahr 1856 14 at at IN cord-028721-x6f26ahr 1856 15 the the DT cord-028721-x6f26ahr 1856 16 level level NN cord-028721-x6f26ahr 1856 17 of of IN cord-028721-x6f26ahr 1856 18 a a DT cord-028721-x6f26ahr 1856 19 defi defi NNP cord-028721-x6f26ahr 1856 20 ned ned NNP cord-028721-x6f26ahr 1856 21 germ germ NN cord-028721-x6f26ahr 1856 22 cell cell NN cord-028721-x6f26ahr 1856 23 type type NN cord-028721-x6f26ahr 1856 24 . . . cord-028721-x6f26ahr 1857 1 852 852 CD cord-028721-x6f26ahr 1858 1 To to TO cord-028721-x6f26ahr 1858 2 avoid avoid VB cord-028721-x6f26ahr 1858 3 confusion confusion NN cord-028721-x6f26ahr 1858 4 the the DT cord-028721-x6f26ahr 1858 5 term term NN cord-028721-x6f26ahr 1858 6 irregular irregular JJ cord-028721-x6f26ahr 1858 7 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 1858 8 has have VBZ cord-028721-x6f26ahr 1858 9 been be VBN cord-028721-x6f26ahr 1858 10 proposed propose VBN cord-028721-x6f26ahr 1858 11 853 853 CD cord-028721-x6f26ahr 1858 12 for for IN cord-028721-x6f26ahr 1858 13 testicular testicular JJ cord-028721-x6f26ahr 1858 14 biopsies biopsy NNS cord-028721-x6f26ahr 1858 15 with with IN cord-028721-x6f26ahr 1858 16 decreased decreased JJ cord-028721-x6f26ahr 1858 17 numbers number NNS cord-028721-x6f26ahr 1858 18 of of IN cord-028721-x6f26ahr 1858 19 germ germ NN cord-028721-x6f26ahr 1858 20 cells cell NNS cord-028721-x6f26ahr 1858 21 , , , cord-028721-x6f26ahr 1858 22 subclassifi subclassifi IN cord-028721-x6f26ahr 1858 23 ed ed NN cord-028721-x6f26ahr 1858 24 as as IN cord-028721-x6f26ahr 1858 25 slight slight JJ cord-028721-x6f26ahr 1858 26 , , , cord-028721-x6f26ahr 1858 27 moderate moderate JJ cord-028721-x6f26ahr 1858 28 , , , cord-028721-x6f26ahr 1858 29 or or CC cord-028721-x6f26ahr 1858 30 severe severe JJ cord-028721-x6f26ahr 1858 31 . . . cord-028721-x6f26ahr 1859 1 However however RB cord-028721-x6f26ahr 1859 2 , , , cord-028721-x6f26ahr 1859 3 this this DT cord-028721-x6f26ahr 1859 4 diagnosis diagnosis NN cord-028721-x6f26ahr 1859 5 is be VBZ cord-028721-x6f26ahr 1859 6 of of IN cord-028721-x6f26ahr 1859 7 little little JJ cord-028721-x6f26ahr 1859 8 help help NN cord-028721-x6f26ahr 1859 9 to to IN cord-028721-x6f26ahr 1859 10 clinicians clinician NNS cord-028721-x6f26ahr 1859 11 . . . cord-028721-x6f26ahr 1860 1 The the DT cord-028721-x6f26ahr 1860 2 reported reported JJ cord-028721-x6f26ahr 1860 3 frequency frequency NN cord-028721-x6f26ahr 1860 4 of of IN cord-028721-x6f26ahr 1860 5 spermatocytic spermatocytic NNP cord-028721-x6f26ahr 1860 6 ( ( -LRB- cord-028721-x6f26ahr 1860 7 meiotic meiotic JJ cord-028721-x6f26ahr 1860 8 ) ) -RRB- cord-028721-x6f26ahr 1860 9 arrest arrest VB cord-028721-x6f26ahr 1860 10 in in IN cord-028721-x6f26ahr 1860 11 infertile infertile JJ cord-028721-x6f26ahr 1860 12 men man NNS cord-028721-x6f26ahr 1860 13 varies vary VBZ cord-028721-x6f26ahr 1860 14 from from IN cord-028721-x6f26ahr 1860 15 12 12 CD cord-028721-x6f26ahr 1860 16 % % NN cord-028721-x6f26ahr 1860 17 854 854 CD cord-028721-x6f26ahr 1860 18 to to IN cord-028721-x6f26ahr 1860 19 32.1 32.1 CD cord-028721-x6f26ahr 1860 20 % % NN cord-028721-x6f26ahr 1860 21 855 855 CD cord-028721-x6f26ahr 1860 22 and and CC cord-028721-x6f26ahr 1860 23 is be VBZ cord-028721-x6f26ahr 1860 24 present present JJ cord-028721-x6f26ahr 1860 25 in in IN cord-028721-x6f26ahr 1860 26 one one CD cord-028721-x6f26ahr 1860 27 or or CC cord-028721-x6f26ahr 1860 28 both both DT cord-028721-x6f26ahr 1860 29 testes testis NNS cord-028721-x6f26ahr 1860 30 of of IN cord-028721-x6f26ahr 1860 31 about about IN cord-028721-x6f26ahr 1860 32 18 18 CD cord-028721-x6f26ahr 1860 33 % % NN cord-028721-x6f26ahr 1860 34 of of IN cord-028721-x6f26ahr 1860 35 oligozoospermic oligozoospermic NNP cord-028721-x6f26ahr 1860 36 or or CC cord-028721-x6f26ahr 1860 37 azoospermic azoospermic NNP cord-028721-x6f26ahr 1860 38 patients patient NNS cord-028721-x6f26ahr 1860 39 . . . cord-028721-x6f26ahr 1861 1 856 856 CD cord-028721-x6f26ahr 1862 1 If if IN cord-028721-x6f26ahr 1862 2 observed observe VBN cord-028721-x6f26ahr 1862 3 in in IN cord-028721-x6f26ahr 1862 4 only only RB cord-028721-x6f26ahr 1862 5 one one CD cord-028721-x6f26ahr 1862 6 testis testis NN cord-028721-x6f26ahr 1862 7 , , , cord-028721-x6f26ahr 1862 8 the the DT cord-028721-x6f26ahr 1862 9 contralateral contralateral JJ cord-028721-x6f26ahr 1862 10 testis testis NN cord-028721-x6f26ahr 1862 11 may may MD cord-028721-x6f26ahr 1862 12 show show VB cord-028721-x6f26ahr 1862 13 histologic histologic JJ cord-028721-x6f26ahr 1862 14 changes change NNS cord-028721-x6f26ahr 1862 15 ranging range VBG cord-028721-x6f26ahr 1862 16 from from IN cord-028721-x6f26ahr 1862 17 normal normal JJ cord-028721-x6f26ahr 1862 18 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1862 19 to to IN cord-028721-x6f26ahr 1862 20 hyalinized hyalinize VBN cord-028721-x6f26ahr 1862 21 tubules tubule NNS cord-028721-x6f26ahr 1862 22 . . . cord-028721-x6f26ahr 1863 1 Disorganization disorganization NN cord-028721-x6f26ahr 1863 2 of of IN cord-028721-x6f26ahr 1863 3 the the DT cord-028721-x6f26ahr 1863 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 1863 5 tubular tubular JJ cord-028721-x6f26ahr 1863 6 cell cell NN cord-028721-x6f26ahr 1863 7 layers layer NNS cord-028721-x6f26ahr 1863 8 is be VBZ cord-028721-x6f26ahr 1863 9 another another DT cord-028721-x6f26ahr 1863 10 frequent frequent JJ cord-028721-x6f26ahr 1863 11 diagnosis diagnosis NN cord-028721-x6f26ahr 1863 12 in in IN cord-028721-x6f26ahr 1863 13 testicular testicular JJ cord-028721-x6f26ahr 1863 14 biopsies biopsy NNS cord-028721-x6f26ahr 1863 15 , , , cord-028721-x6f26ahr 1863 16 848,857,858 848,857,858 CD cord-028721-x6f26ahr 1863 17 but but CC cord-028721-x6f26ahr 1863 18 this this DT cord-028721-x6f26ahr 1863 19 term term NN cord-028721-x6f26ahr 1863 20 is be VBZ cord-028721-x6f26ahr 1863 21 rejected reject VBN cord-028721-x6f26ahr 1863 22 by by IN cord-028721-x6f26ahr 1863 23 many many JJ cord-028721-x6f26ahr 1863 24 pathologists pathologist NNS cord-028721-x6f26ahr 1863 25 . . . cord-028721-x6f26ahr 1864 1 Actual actual JJ cord-028721-x6f26ahr 1864 2 disorganization disorganization NN cord-028721-x6f26ahr 1864 3 of of IN cord-028721-x6f26ahr 1864 4 the the DT cord-028721-x6f26ahr 1864 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 1864 6 tubular tubular JJ cord-028721-x6f26ahr 1864 7 cells cell NNS cord-028721-x6f26ahr 1864 8 is be VBZ cord-028721-x6f26ahr 1864 9 unlikely unlikely JJ cord-028721-x6f26ahr 1864 10 and and CC cord-028721-x6f26ahr 1864 11 has have VBZ cord-028721-x6f26ahr 1864 12 not not RB cord-028721-x6f26ahr 1864 13 been be VBN cord-028721-x6f26ahr 1864 14 demonstrated demonstrate VBN cord-028721-x6f26ahr 1864 15 in in IN cord-028721-x6f26ahr 1864 16 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 1864 17 studies study NNS cord-028721-x6f26ahr 1864 18 . . . cord-028721-x6f26ahr 1865 1 In in IN cord-028721-x6f26ahr 1865 2 most most JJS cord-028721-x6f26ahr 1865 3 cases case NNS cord-028721-x6f26ahr 1865 4 , , , cord-028721-x6f26ahr 1865 5 the the DT cord-028721-x6f26ahr 1865 6 apparent apparent JJ cord-028721-x6f26ahr 1865 7 disorganization disorganization NN cord-028721-x6f26ahr 1865 8 is be VBZ cord-028721-x6f26ahr 1865 9 an an DT cord-028721-x6f26ahr 1865 10 artifact artifact NN cord-028721-x6f26ahr 1865 11 induced induce VBN cord-028721-x6f26ahr 1865 12 by by IN cord-028721-x6f26ahr 1865 13 handling handle VBG cord-028721-x6f26ahr 1865 14 or or CC cord-028721-x6f26ahr 1865 15 fi fi NN cord-028721-x6f26ahr 1865 16 xation xation NN cord-028721-x6f26ahr 1865 17 . . . cord-028721-x6f26ahr 1866 1 859 859 CD cord-028721-x6f26ahr 1866 2 , , , cord-028721-x6f26ahr 1866 3 860 860 CD cord-028721-x6f26ahr 1867 1 The the DT cord-028721-x6f26ahr 1867 2 term term NN cord-028721-x6f26ahr 1867 3 tubular tubular JJ cord-028721-x6f26ahr 1867 4 blockage blockage NN cord-028721-x6f26ahr 1867 5 was be VBD cord-028721-x6f26ahr 1867 6 introduced introduce VBN cord-028721-x6f26ahr 1867 7 by by IN cord-028721-x6f26ahr 1867 8 Meinhard Meinhard NNP cord-028721-x6f26ahr 1867 9 and and CC cord-028721-x6f26ahr 1867 10 co co NNS cord-028721-x6f26ahr 1867 11 - - NNS cord-028721-x6f26ahr 1867 12 workers worker NNS cord-028721-x6f26ahr 1867 13 858 858 CD cord-028721-x6f26ahr 1867 14 for for IN cord-028721-x6f26ahr 1867 15 testes testis NNS cord-028721-x6f26ahr 1867 16 with with IN cord-028721-x6f26ahr 1867 17 at at RB cord-028721-x6f26ahr 1867 18 least least JJS cord-028721-x6f26ahr 1867 19 50 50 CD cord-028721-x6f26ahr 1867 20 % % NN cord-028721-x6f26ahr 1867 21 of of IN cord-028721-x6f26ahr 1867 22 seminiferous seminiferous JJ cord-028721-x6f26ahr 1867 23 tubules tubule NNS cord-028721-x6f26ahr 1867 24 devoid devoid JJ cord-028721-x6f26ahr 1867 25 of of IN cord-028721-x6f26ahr 1867 26 a a DT cord-028721-x6f26ahr 1867 27 central central JJ cord-028721-x6f26ahr 1867 28 lumen lumen NN cord-028721-x6f26ahr 1867 29 and and CC cord-028721-x6f26ahr 1867 30 showing show VBG cord-028721-x6f26ahr 1867 31 spatial spatial JJ cord-028721-x6f26ahr 1867 32 disorganization disorganization NN cord-028721-x6f26ahr 1867 33 of of IN cord-028721-x6f26ahr 1867 34 germ germ NN cord-028721-x6f26ahr 1867 35 cells cell NNS cord-028721-x6f26ahr 1867 36 . . . cord-028721-x6f26ahr 1868 1 This this DT cord-028721-x6f26ahr 1868 2 morphology morphology NN cord-028721-x6f26ahr 1868 3 was be VBD cord-028721-x6f26ahr 1868 4 found find VBN cord-028721-x6f26ahr 1868 5 in in IN cord-028721-x6f26ahr 1868 6 28 28 CD cord-028721-x6f26ahr 1868 7 % % NN cord-028721-x6f26ahr 1868 8 of of IN cord-028721-x6f26ahr 1868 9 testicular testicular JJ cord-028721-x6f26ahr 1868 10 biopsies biopsy NNS cord-028721-x6f26ahr 1868 11 from from IN cord-028721-x6f26ahr 1868 12 infertile infertile JJ cord-028721-x6f26ahr 1868 13 men man NNS cord-028721-x6f26ahr 1868 14 , , , cord-028721-x6f26ahr 1868 15 mainly mainly RB cord-028721-x6f26ahr 1868 16 those those DT cord-028721-x6f26ahr 1868 17 with with IN cord-028721-x6f26ahr 1868 18 obstructive obstructive JJ cord-028721-x6f26ahr 1868 19 azoospermia azoospermia NN cord-028721-x6f26ahr 1868 20 . . . cord-028721-x6f26ahr 1869 1 861 861 CD cord-028721-x6f26ahr 1870 1 Although although IN cord-028721-x6f26ahr 1870 2 this this DT cord-028721-x6f26ahr 1870 3 appearance appearance NN cord-028721-x6f26ahr 1870 4 can can MD cord-028721-x6f26ahr 1870 5 result result VB cord-028721-x6f26ahr 1870 6 from from IN cord-028721-x6f26ahr 1870 7 improper improper JJ cord-028721-x6f26ahr 1870 8 fi fi NN cord-028721-x6f26ahr 1870 9 xation xation NN cord-028721-x6f26ahr 1870 10 , , , cord-028721-x6f26ahr 1870 11 862 862 CD cord-028721-x6f26ahr 1870 12 the the DT cord-028721-x6f26ahr 1870 13 accumulation accumulation NN cord-028721-x6f26ahr 1870 14 of of IN cord-028721-x6f26ahr 1870 15 Sertoli sertoli JJ cord-028721-x6f26ahr 1870 16 cells cell NNS cord-028721-x6f26ahr 1870 17 and and CC cord-028721-x6f26ahr 1870 18 immature immature JJ cord-028721-x6f26ahr 1870 19 germ germ NN cord-028721-x6f26ahr 1870 20 cells cell NNS cord-028721-x6f26ahr 1870 21 in in IN cord-028721-x6f26ahr 1870 22 the the DT cord-028721-x6f26ahr 1870 23 centers center NNS cord-028721-x6f26ahr 1870 24 of of IN cord-028721-x6f26ahr 1870 25 tubules tubule NNS cord-028721-x6f26ahr 1870 26 suggests suggest VBZ cord-028721-x6f26ahr 1870 27 a a DT cord-028721-x6f26ahr 1870 28 specifi specifi NN cord-028721-x6f26ahr 1870 29 c c NN cord-028721-x6f26ahr 1870 30 lesion lesion NN cord-028721-x6f26ahr 1870 31 , , , cord-028721-x6f26ahr 1870 32 a a DT cord-028721-x6f26ahr 1870 33 variant variant NN cord-028721-x6f26ahr 1870 34 of of IN cord-028721-x6f26ahr 1870 35 germ germ NN cord-028721-x6f26ahr 1870 36 cell cell NN cord-028721-x6f26ahr 1870 37 sloughing slough VBG cord-028721-x6f26ahr 1870 38 . . . cord-028721-x6f26ahr 1871 1 Diagnostic diagnostic JJ cord-028721-x6f26ahr 1871 2 confusion confusion NN cord-028721-x6f26ahr 1871 3 decreased decrease VBD cord-028721-x6f26ahr 1871 4 the the DT cord-028721-x6f26ahr 1871 5 interest interest NN cord-028721-x6f26ahr 1871 6 and and CC cord-028721-x6f26ahr 1871 7 trust trust NN cord-028721-x6f26ahr 1871 8 of of IN cord-028721-x6f26ahr 1871 9 urologists urologist NNS cord-028721-x6f26ahr 1871 10 and and CC cord-028721-x6f26ahr 1871 11 andrologists andrologist NNS cord-028721-x6f26ahr 1871 12 in in IN cord-028721-x6f26ahr 1871 13 the the DT cord-028721-x6f26ahr 1871 14 study study NN cord-028721-x6f26ahr 1871 15 of of IN cord-028721-x6f26ahr 1871 16 testicular testicular JJ cord-028721-x6f26ahr 1871 17 biopsies biopsy NNS cord-028721-x6f26ahr 1871 18 . . . cord-028721-x6f26ahr 1872 1 Subsequent subsequent JJ cord-028721-x6f26ahr 1872 2 studies study NNS cord-028721-x6f26ahr 1872 3 attempted attempt VBD cord-028721-x6f26ahr 1872 4 to to TO cord-028721-x6f26ahr 1872 5 correlate correlate VB cord-028721-x6f26ahr 1872 6 semen semen NN cord-028721-x6f26ahr 1872 7 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 1872 8 concentration concentration NN cord-028721-x6f26ahr 1872 9 with with IN cord-028721-x6f26ahr 1872 10 testicular testicular JJ cord-028721-x6f26ahr 1872 11 size size NN cord-028721-x6f26ahr 1872 12 and and CC cord-028721-x6f26ahr 1872 13 biochemical biochemical JJ cord-028721-x6f26ahr 1872 14 fi fi NN cord-028721-x6f26ahr 1872 15 ndings nding NNS cord-028721-x6f26ahr 1872 16 such such JJ cord-028721-x6f26ahr 1872 17 as as IN cord-028721-x6f26ahr 1872 18 serum serum NN cord-028721-x6f26ahr 1872 19 levels level NNS cord-028721-x6f26ahr 1872 20 of of IN cord-028721-x6f26ahr 1872 21 FSH fsh NN cord-028721-x6f26ahr 1872 22 , , , cord-028721-x6f26ahr 1872 23 and and CC cord-028721-x6f26ahr 1872 24 testicular testicular JJ cord-028721-x6f26ahr 1872 25 biopsies biopsy NNS cord-028721-x6f26ahr 1872 26 were be VBD cord-028721-x6f26ahr 1872 27 undertaken undertake VBN cord-028721-x6f26ahr 1872 28 in in IN cord-028721-x6f26ahr 1872 29 only only RB cord-028721-x6f26ahr 1872 30 a a DT cord-028721-x6f26ahr 1872 31 limited limited JJ cord-028721-x6f26ahr 1872 32 number number NN cord-028721-x6f26ahr 1872 33 of of IN cord-028721-x6f26ahr 1872 34 oligozoospermic oligozoospermic NNP cord-028721-x6f26ahr 1872 35 and and CC cord-028721-x6f26ahr 1872 36 azoospermic azoospermic NNP cord-028721-x6f26ahr 1872 37 patients patient NNS cord-028721-x6f26ahr 1872 38 . . . cord-028721-x6f26ahr 1873 1 859 859 CD cord-028721-x6f26ahr 1873 2 , , , cord-028721-x6f26ahr 1873 3 862 862 CD cord-028721-x6f26ahr 1873 4 , , , cord-028721-x6f26ahr 1873 5 863 863 CD cord-028721-x6f26ahr 1874 1 However however RB cord-028721-x6f26ahr 1874 2 , , , cord-028721-x6f26ahr 1874 3 these these DT cord-028721-x6f26ahr 1874 4 studies study NNS cord-028721-x6f26ahr 1874 5 were be VBD cord-028721-x6f26ahr 1874 6 also also RB cord-028721-x6f26ahr 1874 7 discouraging discouraging JJ cord-028721-x6f26ahr 1874 8 because because IN cord-028721-x6f26ahr 1874 9 FSH FSH NNP cord-028721-x6f26ahr 1874 10 was be VBD cord-028721-x6f26ahr 1874 11 found find VBN cord-028721-x6f26ahr 1874 12 to to TO cord-028721-x6f26ahr 1874 13 correlate correlate VB cord-028721-x6f26ahr 1874 14 poorly poorly RB cord-028721-x6f26ahr 1874 15 with with IN cord-028721-x6f26ahr 1874 16 numbers number NNS cord-028721-x6f26ahr 1874 17 of of IN cord-028721-x6f26ahr 1874 18 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 1874 19 in in IN cord-028721-x6f26ahr 1874 20 the the DT cord-028721-x6f26ahr 1874 21 semen semen NN cord-028721-x6f26ahr 1874 22 but but CC cord-028721-x6f26ahr 1874 23 better well JJR cord-028721-x6f26ahr 1874 24 with with IN cord-028721-x6f26ahr 1874 25 numbers number NNS cord-028721-x6f26ahr 1874 26 of of IN cord-028721-x6f26ahr 1874 27 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1874 28 in in IN cord-028721-x6f26ahr 1874 29 the the DT cord-028721-x6f26ahr 1874 30 seminiferous seminiferous JJ cord-028721-x6f26ahr 1874 31 tubules tubule NNS cord-028721-x6f26ahr 1874 32 , , , cord-028721-x6f26ahr 1875 1 864 864 CD cord-028721-x6f26ahr 1875 2 and and CC cord-028721-x6f26ahr 1875 3 normal normal JJ cord-028721-x6f26ahr 1875 4 numbers number NNS cord-028721-x6f26ahr 1875 5 of of IN cord-028721-x6f26ahr 1875 6 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 1875 7 can can MD cord-028721-x6f26ahr 1875 8 be be VB cord-028721-x6f26ahr 1875 9 produced produce VBN cord-028721-x6f26ahr 1875 10 by by IN cord-028721-x6f26ahr 1875 11 relatively relatively RB cord-028721-x6f26ahr 1875 12 small small JJ cord-028721-x6f26ahr 1875 13 testes testis NNS cord-028721-x6f26ahr 1875 14 whereas whereas IN cord-028721-x6f26ahr 1875 15 some some DT cord-028721-x6f26ahr 1875 16 large large JJ cord-028721-x6f26ahr 1875 17 testes testis NNS cord-028721-x6f26ahr 1875 18 have have VBP cord-028721-x6f26ahr 1875 19 no no DT cord-028721-x6f26ahr 1875 20 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1875 21 . . . cord-028721-x6f26ahr 1876 1 In in IN cord-028721-x6f26ahr 1876 2 recent recent JJ cord-028721-x6f26ahr 1876 3 years year NNS cord-028721-x6f26ahr 1876 4 , , , cord-028721-x6f26ahr 1876 5 serum serum NN cord-028721-x6f26ahr 1876 6 levels level NNS cord-028721-x6f26ahr 1876 7 of of IN cord-028721-x6f26ahr 1876 8 inhibin inhibin NNP cord-028721-x6f26ahr 1876 9 B B NNP cord-028721-x6f26ahr 1876 10 have have VBP cord-028721-x6f26ahr 1876 11 been be VBN cord-028721-x6f26ahr 1876 12 shown show VBN cord-028721-x6f26ahr 1876 13 to to TO cord-028721-x6f26ahr 1876 14 have have VB cord-028721-x6f26ahr 1876 15 a a DT cord-028721-x6f26ahr 1876 16 positive positive JJ cord-028721-x6f26ahr 1876 17 correlation correlation NN cord-028721-x6f26ahr 1876 18 with with IN cord-028721-x6f26ahr 1876 19 spermatozoon spermatozoon NN cord-028721-x6f26ahr 1876 20 numbers number NNS cord-028721-x6f26ahr 1876 21 and and CC cord-028721-x6f26ahr 1876 22 serum serum NN cord-028721-x6f26ahr 1876 23 FSH fsh NN cord-028721-x6f26ahr 1876 24 level level NN cord-028721-x6f26ahr 1876 25 . . . cord-028721-x6f26ahr 1877 1 865 865 CD cord-028721-x6f26ahr 1877 2 , , , cord-028721-x6f26ahr 1877 3 866 866 CD cord-028721-x6f26ahr 1878 1 The the DT cord-028721-x6f26ahr 1878 2 development development NN cord-028721-x6f26ahr 1878 3 of of IN cord-028721-x6f26ahr 1878 4 morphometry morphometry NN cord-028721-x6f26ahr 1878 5 caused cause VBD cord-028721-x6f26ahr 1878 6 a a DT cord-028721-x6f26ahr 1878 7 resurgence resurgence NN cord-028721-x6f26ahr 1878 8 of of IN cord-028721-x6f26ahr 1878 9 interest interest NN cord-028721-x6f26ahr 1878 10 in in IN cord-028721-x6f26ahr 1878 11 biopsies biopsy NNS cord-028721-x6f26ahr 1878 12 . . . cord-028721-x6f26ahr 1879 1 Many many JJ cord-028721-x6f26ahr 1879 2 semiquantitative semiquantitative JJ cord-028721-x6f26ahr 1879 3 853,867 853,867 CD cord-028721-x6f26ahr 1879 4 - - SYM cord-028721-x6f26ahr 1879 5 869 869 CD cord-028721-x6f26ahr 1879 6 and and CC cord-028721-x6f26ahr 1879 7 quantitative quantitative JJ cord-028721-x6f26ahr 1879 8 [ [ -LRB- cord-028721-x6f26ahr 1879 9 870 870 CD cord-028721-x6f26ahr 1879 10 ] ] -RRB- cord-028721-x6f26ahr 1879 11 [ [ -LRB- cord-028721-x6f26ahr 1879 12 871 871 CD cord-028721-x6f26ahr 1879 13 ] ] -RRB- cord-028721-x6f26ahr 1879 14 [ [ -LRB- cord-028721-x6f26ahr 1879 15 872 872 CD cord-028721-x6f26ahr 1879 16 ] ] -RRB- cord-028721-x6f26ahr 1879 17 [ [ -LRB- cord-028721-x6f26ahr 1879 18 873 873 CD cord-028721-x6f26ahr 1879 19 ] ] -RRB- cord-028721-x6f26ahr 1879 20 [ [ -LRB- cord-028721-x6f26ahr 1879 21 874 874 CD cord-028721-x6f26ahr 1879 22 ] ] -RRB- cord-028721-x6f26ahr 1880 1 [ [ -LRB- cord-028721-x6f26ahr 1880 2 875 875 CD cord-028721-x6f26ahr 1880 3 ] ] -RRB- cord-028721-x6f26ahr 1880 4 studies study NNS cord-028721-x6f26ahr 1880 5 were be VBD cord-028721-x6f26ahr 1880 6 carried carry VBN cord-028721-x6f26ahr 1880 7 out out RP cord-028721-x6f26ahr 1880 8 . . . cord-028721-x6f26ahr 1881 1 The the DT cord-028721-x6f26ahr 1881 2 greatest great JJS cord-028721-x6f26ahr 1881 3 achievements achievement NNS cord-028721-x6f26ahr 1881 4 of of IN cord-028721-x6f26ahr 1881 5 these these DT cord-028721-x6f26ahr 1881 6 studies study NNS cord-028721-x6f26ahr 1881 7 were be VBD cord-028721-x6f26ahr 1881 8 enhancement enhancement NN cord-028721-x6f26ahr 1881 9 of of IN cord-028721-x6f26ahr 1881 10 the the DT cord-028721-x6f26ahr 1881 11 reproducibility reproducibility NN cord-028721-x6f26ahr 1881 12 of of IN cord-028721-x6f26ahr 1881 13 results result NNS cord-028721-x6f26ahr 1881 14 and and CC cord-028721-x6f26ahr 1881 15 better well JJR cord-028721-x6f26ahr 1881 16 evaluation evaluation NN cord-028721-x6f26ahr 1881 17 of of IN cord-028721-x6f26ahr 1881 18 the the DT cord-028721-x6f26ahr 1881 19 reversibility reversibility NN cord-028721-x6f26ahr 1881 20 of of IN cord-028721-x6f26ahr 1881 21 lesions lesion NNS cord-028721-x6f26ahr 1881 22 . . . cord-028721-x6f26ahr 1882 1 Morphometry Morphometry NNP cord-028721-x6f26ahr 1882 2 emerged emerge VBD cord-028721-x6f26ahr 1882 3 as as IN cord-028721-x6f26ahr 1882 4 the the DT cord-028721-x6f26ahr 1882 5 best good JJS cord-028721-x6f26ahr 1882 6 method method NN cord-028721-x6f26ahr 1882 7 to to TO cord-028721-x6f26ahr 1882 8 objectively objectively RB cord-028721-x6f26ahr 1882 9 evaluate evaluate VB cord-028721-x6f26ahr 1882 10 the the DT cord-028721-x6f26ahr 1882 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 1882 12 tubular tubular JJ cord-028721-x6f26ahr 1882 13 cells cell NNS cord-028721-x6f26ahr 1882 14 . . . cord-028721-x6f26ahr 1883 1 876 876 CD cord-028721-x6f26ahr 1884 1 The the DT cord-028721-x6f26ahr 1884 2 scoring scoring NN cord-028721-x6f26ahr 1884 3 method method NN cord-028721-x6f26ahr 1884 4 of of IN cord-028721-x6f26ahr 1884 5 Johnsen Johnsen NNP cord-028721-x6f26ahr 1884 6 , , , cord-028721-x6f26ahr 1884 7 868 868 CD cord-028721-x6f26ahr 1884 8 estimation estimation NN cord-028721-x6f26ahr 1884 9 of of IN cord-028721-x6f26ahr 1884 10 the the DT cord-028721-x6f26ahr 1884 11 germ germ NN cord-028721-x6f26ahr 1884 12 cell/ cell/ POS cord-028721-x6f26ahr 1884 13 Sertoli sertoli JJ cord-028721-x6f26ahr 1884 14 cell cell NN cord-028721-x6f26ahr 1884 15 ratio ratio NN cord-028721-x6f26ahr 1884 16 for for IN cord-028721-x6f26ahr 1884 17 each each DT cord-028721-x6f26ahr 1884 18 germ germ NN cord-028721-x6f26ahr 1884 19 cell cell NN cord-028721-x6f26ahr 1884 20 type type NN cord-028721-x6f26ahr 1884 21 , , , cord-028721-x6f26ahr 1884 22 871 871 CD cord-028721-x6f26ahr 1884 23 and and CC cord-028721-x6f26ahr 1884 24 calculation calculation NN cord-028721-x6f26ahr 1884 25 of of IN cord-028721-x6f26ahr 1884 26 germ germ NN cord-028721-x6f26ahr 1884 27 cell cell NN cord-028721-x6f26ahr 1884 28 number number NN cord-028721-x6f26ahr 1884 29 per per IN cord-028721-x6f26ahr 1884 30 unit unit NN cord-028721-x6f26ahr 1884 31 length length NN cord-028721-x6f26ahr 1884 32 of of IN cord-028721-x6f26ahr 1884 33 seminiferous seminiferous JJ cord-028721-x6f26ahr 1884 34 tubules tubule NNS cord-028721-x6f26ahr 1884 35 870 870 CD cord-028721-x6f26ahr 1884 36 are be VBP cord-028721-x6f26ahr 1884 37 reliable reliable JJ cord-028721-x6f26ahr 1884 38 and and CC cord-028721-x6f26ahr 1884 39 useful useful JJ cord-028721-x6f26ahr 1884 40 . . . cord-028721-x6f26ahr 1885 1 Several several JJ cord-028721-x6f26ahr 1885 2 methods method NNS cord-028721-x6f26ahr 1885 3 are be VBP cord-028721-x6f26ahr 1885 4 available available JJ cord-028721-x6f26ahr 1885 5 to to TO cord-028721-x6f26ahr 1885 6 evaluate evaluate VB cord-028721-x6f26ahr 1885 7 the the DT cord-028721-x6f26ahr 1885 8 Leydig Leydig NNP cord-028721-x6f26ahr 1885 9 cell cell NN cord-028721-x6f26ahr 1885 10 population population NN cord-028721-x6f26ahr 1885 11 , , , cord-028721-x6f26ahr 1885 12 including include VBG cord-028721-x6f26ahr 1885 13 the the DT cord-028721-x6f26ahr 1885 14 mean mean JJ cord-028721-x6f26ahr 1885 15 number number NN cord-028721-x6f26ahr 1885 16 of of IN cord-028721-x6f26ahr 1885 17 cells cell NNS cord-028721-x6f26ahr 1885 18 per per IN cord-028721-x6f26ahr 1885 19 seminiferous seminiferous JJ cord-028721-x6f26ahr 1885 20 tubule tubule NN cord-028721-x6f26ahr 1885 21 and and CC cord-028721-x6f26ahr 1885 22 per per IN cord-028721-x6f26ahr 1885 23 cell cell NN cord-028721-x6f26ahr 1885 24 cluster cluster NN cord-028721-x6f26ahr 1885 25 ; ; : cord-028721-x6f26ahr 1885 26 the the DT cord-028721-x6f26ahr 1885 27 mean mean JJ cord-028721-x6f26ahr 1885 28 number number NN cord-028721-x6f26ahr 1885 29 of of IN cord-028721-x6f26ahr 1885 30 Leydig Leydig NNP cord-028721-x6f26ahr 1885 31 cell cell NN cord-028721-x6f26ahr 1885 32 clusters cluster NNS cord-028721-x6f26ahr 1885 33 per per IN cord-028721-x6f26ahr 1885 34 seminiferous seminiferous JJ cord-028721-x6f26ahr 1885 35 tubule tubule NN cord-028721-x6f26ahr 1885 36 ; ; : cord-028721-x6f26ahr 1885 37 the the DT cord-028721-x6f26ahr 1885 38 ratio ratio NN cord-028721-x6f26ahr 1885 39 of of IN cord-028721-x6f26ahr 1885 40 Leydig Leydig NNP cord-028721-x6f26ahr 1885 41 cell cell NN cord-028721-x6f26ahr 1885 42 area area NN cord-028721-x6f26ahr 1885 43 to to IN cord-028721-x6f26ahr 1885 44 seminiferous seminiferous JJ cord-028721-x6f26ahr 1885 45 tubule tubule NNP cord-028721-x6f26ahr 1885 46 area area NN cord-028721-x6f26ahr 1885 47 ; ; : cord-028721-x6f26ahr 1885 48 877 877 CD cord-028721-x6f26ahr 1885 49 and and CC cord-028721-x6f26ahr 1885 50 the the DT cord-028721-x6f26ahr 1885 51 ratio ratio NN cord-028721-x6f26ahr 1885 52 of of IN cord-028721-x6f26ahr 1885 53 Leydig Leydig NNP cord-028721-x6f26ahr 1885 54 cells cell NNS cord-028721-x6f26ahr 1885 55 to to IN cord-028721-x6f26ahr 1885 56 Sertoli sertoli JJ cord-028721-x6f26ahr 1885 57 cells cell NNS cord-028721-x6f26ahr 1885 58 . . . cord-028721-x6f26ahr 1886 1 878 878 CD cord-028721-x6f26ahr 1887 1 These these DT cord-028721-x6f26ahr 1887 2 methods method NNS cord-028721-x6f26ahr 1887 3 have have VBP cord-028721-x6f26ahr 1887 4 shown show VBN cord-028721-x6f26ahr 1887 5 that that IN cord-028721-x6f26ahr 1887 6 the the DT cord-028721-x6f26ahr 1887 7 appearance appearance NN cord-028721-x6f26ahr 1887 8 of of IN cord-028721-x6f26ahr 1887 9 Leydig Leydig NNP cord-028721-x6f26ahr 1887 10 cell cell NN cord-028721-x6f26ahr 1887 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1887 12 described describe VBN cord-028721-x6f26ahr 1887 13 in in IN cord-028721-x6f26ahr 1887 14 many many JJ cord-028721-x6f26ahr 1887 15 conditions condition NNS cord-028721-x6f26ahr 1887 16 is be VBZ cord-028721-x6f26ahr 1887 17 false false JJ cord-028721-x6f26ahr 1887 18 , , , cord-028721-x6f26ahr 1887 19 and and CC cord-028721-x6f26ahr 1887 20 that that IN cord-028721-x6f26ahr 1887 21 true true JJ cord-028721-x6f26ahr 1887 22 Leydig Leydig NNP cord-028721-x6f26ahr 1887 23 cell cell NN cord-028721-x6f26ahr 1887 24 hyperplasia hyperplasia NN cord-028721-x6f26ahr 1887 25 is be VBZ cord-028721-x6f26ahr 1887 26 extremely extremely RB cord-028721-x6f26ahr 1887 27 rare rare JJ cord-028721-x6f26ahr 1887 28 . . . cord-028721-x6f26ahr 1888 1 Optimal optimal JJ cord-028721-x6f26ahr 1888 2 interpretation interpretation NN cord-028721-x6f26ahr 1888 3 of of IN cord-028721-x6f26ahr 1888 4 testicular testicular JJ cord-028721-x6f26ahr 1888 5 biopsies biopsy NNS cord-028721-x6f26ahr 1888 6 depends depend VBZ cord-028721-x6f26ahr 1888 7 on on IN cord-028721-x6f26ahr 1888 8 the the DT cord-028721-x6f26ahr 1888 9 surgical surgical JJ cord-028721-x6f26ahr 1888 10 technique technique NN cord-028721-x6f26ahr 1888 11 by by IN cord-028721-x6f26ahr 1888 12 which which WDT cord-028721-x6f26ahr 1888 13 the the DT cord-028721-x6f26ahr 1888 14 tissue tissue NN cord-028721-x6f26ahr 1888 15 sample sample NN cord-028721-x6f26ahr 1888 16 is be VBZ cord-028721-x6f26ahr 1888 17 taken take VBN cord-028721-x6f26ahr 1888 18 , , , cord-028721-x6f26ahr 1888 19 the the DT cord-028721-x6f26ahr 1888 20 care care NN cord-028721-x6f26ahr 1888 21 and and CC cord-028721-x6f26ahr 1888 22 delicacy delicacy NN cord-028721-x6f26ahr 1888 23 with with IN cord-028721-x6f26ahr 1888 24 which which WDT cord-028721-x6f26ahr 1888 25 the the DT cord-028721-x6f26ahr 1888 26 specimen specimen NN cord-028721-x6f26ahr 1888 27 is be VBZ cord-028721-x6f26ahr 1888 28 manipulated manipulate VBN cord-028721-x6f26ahr 1888 29 , , , cord-028721-x6f26ahr 1888 30 and and CC cord-028721-x6f26ahr 1888 31 proper proper JJ cord-028721-x6f26ahr 1888 32 fi fi NN cord-028721-x6f26ahr 1888 33 xation xation NN cord-028721-x6f26ahr 1888 34 and and CC cord-028721-x6f26ahr 1888 35 processing processing NN cord-028721-x6f26ahr 1888 36 of of IN cord-028721-x6f26ahr 1888 37 the the DT cord-028721-x6f26ahr 1888 38 tissue tissue NN cord-028721-x6f26ahr 1888 39 . . . cord-028721-x6f26ahr 1889 1 The the DT cord-028721-x6f26ahr 1889 2 size size NN cord-028721-x6f26ahr 1889 3 of of IN cord-028721-x6f26ahr 1889 4 the the DT cord-028721-x6f26ahr 1889 5 biopsy biopsy NN cord-028721-x6f26ahr 1889 6 should should MD cord-028721-x6f26ahr 1889 7 not not RB cord-028721-x6f26ahr 1889 8 be be VB cord-028721-x6f26ahr 1889 9 greater great JJR cord-028721-x6f26ahr 1889 10 than than IN cord-028721-x6f26ahr 1889 11 a a DT cord-028721-x6f26ahr 1889 12 grain grain NN cord-028721-x6f26ahr 1889 13 of of IN cord-028721-x6f26ahr 1889 14 rice rice NN cord-028721-x6f26ahr 1889 15 : : : cord-028721-x6f26ahr 1889 16 that that RB cord-028721-x6f26ahr 1889 17 is is RB cord-028721-x6f26ahr 1889 18 , , , cord-028721-x6f26ahr 1889 19 no no DT cord-028721-x6f26ahr 1889 20 diameter diameter NN cord-028721-x6f26ahr 1889 21 should should MD cord-028721-x6f26ahr 1889 22 be be VB cord-028721-x6f26ahr 1889 23 greater great JJR cord-028721-x6f26ahr 1889 24 than than IN cord-028721-x6f26ahr 1889 25 3 3 CD cord-028721-x6f26ahr 1889 26 mm mm NN cord-028721-x6f26ahr 1889 27 . . . cord-028721-x6f26ahr 1890 1 This this DT cord-028721-x6f26ahr 1890 2 amounts amount VBZ cord-028721-x6f26ahr 1890 3 to to IN cord-028721-x6f26ahr 1890 4 about about RB cord-028721-x6f26ahr 1890 5 0.12 0.12 CD cord-028721-x6f26ahr 1890 6 % % NN cord-028721-x6f26ahr 1890 7 of of IN cord-028721-x6f26ahr 1890 8 testicular testicular JJ cord-028721-x6f26ahr 1890 9 volume volume NN cord-028721-x6f26ahr 1891 1 ( ( -LRB- cord-028721-x6f26ahr 1891 2 normal normal JJ cord-028721-x6f26ahr 1891 3 volume volume NN cord-028721-x6f26ahr 1891 4 is be VBZ cord-028721-x6f26ahr 1891 5 approximately approximately RB cord-028721-x6f26ahr 1891 6 20 20 CD cord-028721-x6f26ahr 1891 7 mL ml NN cord-028721-x6f26ahr 1891 8 ) ) -RRB- cord-028721-x6f26ahr 1891 9 . . . cord-028721-x6f26ahr 1892 1 The the DT cord-028721-x6f26ahr 1892 2 biopsy biopsy NN cord-028721-x6f26ahr 1892 3 should should MD cord-028721-x6f26ahr 1892 4 be be VB cord-028721-x6f26ahr 1892 5 bilateral bilateral JJ cord-028721-x6f26ahr 1892 6 because because IN cord-028721-x6f26ahr 1892 7 in in IN cord-028721-x6f26ahr 1892 8 more more JJR cord-028721-x6f26ahr 1892 9 than than IN cord-028721-x6f26ahr 1892 10 28 28 CD cord-028721-x6f26ahr 1892 11 % % NN cord-028721-x6f26ahr 1892 12 of of IN cord-028721-x6f26ahr 1892 13 patients patient NNS cord-028721-x6f26ahr 1892 14 the the DT cord-028721-x6f26ahr 1892 15 fi fi NNP cord-028721-x6f26ahr 1892 16 ndings nding NNS cord-028721-x6f26ahr 1892 17 differ differ VBP cord-028721-x6f26ahr 1892 18 between between IN cord-028721-x6f26ahr 1892 19 the the DT cord-028721-x6f26ahr 1892 20 testes testis NNS cord-028721-x6f26ahr 1892 21 . . . cord-028721-x6f26ahr 1893 1 At at IN cord-028721-x6f26ahr 1893 2 the the DT cord-028721-x6f26ahr 1893 3 time time NN cord-028721-x6f26ahr 1893 4 of of IN cord-028721-x6f26ahr 1893 5 biopsy biopsy NN cord-028721-x6f26ahr 1893 6 , , , cord-028721-x6f26ahr 1893 7 the the DT cord-028721-x6f26ahr 1893 8 testicular testicular JJ cord-028721-x6f26ahr 1893 9 axes axis NNS cord-028721-x6f26ahr 1893 10 should should MD cord-028721-x6f26ahr 1893 11 be be VB cord-028721-x6f26ahr 1893 12 measured measure VBN cord-028721-x6f26ahr 1893 13 as as IN cord-028721-x6f26ahr 1893 14 the the DT cord-028721-x6f26ahr 1893 15 basis basis NN cord-028721-x6f26ahr 1893 16 of of IN cord-028721-x6f26ahr 1893 17 quantitative quantitative JJ cord-028721-x6f26ahr 1893 18 studies study NNS cord-028721-x6f26ahr 1893 19 . . . cord-028721-x6f26ahr 1894 1 The the DT cord-028721-x6f26ahr 1894 2 tissue tissue NN cord-028721-x6f26ahr 1894 3 should should MD cord-028721-x6f26ahr 1894 4 be be VB cord-028721-x6f26ahr 1894 5 taken take VBN cord-028721-x6f26ahr 1894 6 opposite opposite RB cord-028721-x6f26ahr 1894 7 to to IN cord-028721-x6f26ahr 1894 8 the the DT cord-028721-x6f26ahr 1894 9 rete rete NN cord-028721-x6f26ahr 1894 10 testis testis NN cord-028721-x6f26ahr 1894 11 through through IN cord-028721-x6f26ahr 1894 12 a a DT cord-028721-x6f26ahr 1894 13 4 4 CD cord-028721-x6f26ahr 1894 14 - - SYM cord-028721-x6f26ahr 1894 15 5 5 CD cord-028721-x6f26ahr 1894 16 mm mm CD cord-028721-x6f26ahr 1894 17 incision incision NN cord-028721-x6f26ahr 1894 18 in in IN cord-028721-x6f26ahr 1894 19 the the DT cord-028721-x6f26ahr 1894 20 tunica tunica NNP cord-028721-x6f26ahr 1894 21 albuginea albuginea NNP cord-028721-x6f26ahr 1894 22 . . . cord-028721-x6f26ahr 1895 1 This this DT cord-028721-x6f26ahr 1895 2 parenchyma parenchyma NN cord-028721-x6f26ahr 1895 3 herniates herniate VBZ cord-028721-x6f26ahr 1895 4 through through IN cord-028721-x6f26ahr 1895 5 the the DT cord-028721-x6f26ahr 1895 6 incision incision NN cord-028721-x6f26ahr 1895 7 and and CC cord-028721-x6f26ahr 1895 8 can can MD cord-028721-x6f26ahr 1895 9 be be VB cord-028721-x6f26ahr 1895 10 carefully carefully RB cord-028721-x6f26ahr 1895 11 snipped snip VBN cord-028721-x6f26ahr 1895 12 off off RP cord-028721-x6f26ahr 1895 13 . . . cord-028721-x6f26ahr 1896 1 If if IN cord-028721-x6f26ahr 1896 2 only only RB cord-028721-x6f26ahr 1896 3 light light JJ cord-028721-x6f26ahr 1896 4 microscopy microscopy NN cord-028721-x6f26ahr 1896 5 is be VBZ cord-028721-x6f26ahr 1896 6 to to TO cord-028721-x6f26ahr 1896 7 be be VB cord-028721-x6f26ahr 1896 8 performed perform VBN cord-028721-x6f26ahr 1896 9 , , , cord-028721-x6f26ahr 1896 10 the the DT cord-028721-x6f26ahr 1896 11 specimen specimen NN cord-028721-x6f26ahr 1896 12 should should MD cord-028721-x6f26ahr 1896 13 be be VB cord-028721-x6f26ahr 1896 14 fi fi FW cord-028721-x6f26ahr 1896 15 xed xed FW cord-028721-x6f26ahr 1896 16 in in IN cord-028721-x6f26ahr 1896 17 Bouin Bouin NNP cord-028721-x6f26ahr 1896 18 's 's POS cord-028721-x6f26ahr 1896 19 fl fl NNP cord-028721-x6f26ahr 1896 20 uid uid NN cord-028721-x6f26ahr 1896 21 for for IN cord-028721-x6f26ahr 1896 22 24 24 CD cord-028721-x6f26ahr 1896 23 hours hour NNS cord-028721-x6f26ahr 1896 24 . . . cord-028721-x6f26ahr 1897 1 If if IN cord-028721-x6f26ahr 1897 2 electron electron NN cord-028721-x6f26ahr 1897 3 microscopy microscopy NN cord-028721-x6f26ahr 1897 4 is be VBZ cord-028721-x6f26ahr 1897 5 indicated indicate VBN cord-028721-x6f26ahr 1897 6 , , , cord-028721-x6f26ahr 1897 7 a a DT cord-028721-x6f26ahr 1897 8 small small JJ cord-028721-x6f26ahr 1897 9 biopsy biopsy NN cord-028721-x6f26ahr 1897 10 fragment fragment NN cord-028721-x6f26ahr 1897 11 should should MD cord-028721-x6f26ahr 1897 12 be be VB cord-028721-x6f26ahr 1897 13 fi fi FW cord-028721-x6f26ahr 1897 14 xed xed FW cord-028721-x6f26ahr 1897 15 in in IN cord-028721-x6f26ahr 1897 16 glutaraldehyde glutaraldehyde NN cord-028721-x6f26ahr 1897 17 - - HYPH cord-028721-x6f26ahr 1897 18 osmium osmium NN cord-028721-x6f26ahr 1897 19 tetroxide tetroxide NN cord-028721-x6f26ahr 1897 20 or or CC cord-028721-x6f26ahr 1897 21 a a DT cord-028721-x6f26ahr 1897 22 similar similar JJ cord-028721-x6f26ahr 1897 23 fi fi NN cord-028721-x6f26ahr 1897 24 xative xative NN cord-028721-x6f26ahr 1897 25 . . . cord-028721-x6f26ahr 1898 1 To to TO cord-028721-x6f26ahr 1898 2 perform perform VB cord-028721-x6f26ahr 1898 3 meiotic meiotic JJ cord-028721-x6f26ahr 1898 4 studies study NNS cord-028721-x6f26ahr 1898 5 , , , cord-028721-x6f26ahr 1898 6 testicular testicular JJ cord-028721-x6f26ahr 1898 7 biopsy biopsy NN cord-028721-x6f26ahr 1898 8 should should MD cord-028721-x6f26ahr 1898 9 be be VB cord-028721-x6f26ahr 1898 10 processed process VBN cord-028721-x6f26ahr 1898 11 by by IN cord-028721-x6f26ahr 1898 12 air air NN cord-028721-x6f26ahr 1898 13 - - HYPH cord-028721-x6f26ahr 1898 14 drying drying NN cord-028721-x6f26ahr 1898 15 or or CC cord-028721-x6f26ahr 1898 16 surface surface NN cord-028721-x6f26ahr 1898 17 - - HYPH cord-028721-x6f26ahr 1898 18 spreading spread VBG cord-028721-x6f26ahr 1898 19 methods method NNS cord-028721-x6f26ahr 1898 20 . . . cord-028721-x6f26ahr 1899 1 The the DT cord-028721-x6f26ahr 1899 2 examination examination NN cord-028721-x6f26ahr 1899 3 of of IN cord-028721-x6f26ahr 1899 4 testicular testicular JJ cord-028721-x6f26ahr 1899 5 biopsies biopsy NNS cord-028721-x6f26ahr 1899 6 includes include VBZ cord-028721-x6f26ahr 1899 7 qualitative qualitative JJ cord-028721-x6f26ahr 1899 8 and and CC cord-028721-x6f26ahr 1899 9 quantitative quantitative JJ cord-028721-x6f26ahr 1899 10 evaluation evaluation NN cord-028721-x6f26ahr 1899 11 of of IN cord-028721-x6f26ahr 1899 12 the the DT cord-028721-x6f26ahr 1899 13 testis testis NN cord-028721-x6f26ahr 1899 14 and and CC cord-028721-x6f26ahr 1899 15 correlation correlation NN cord-028721-x6f26ahr 1899 16 between between IN cord-028721-x6f26ahr 1899 17 the the DT cord-028721-x6f26ahr 1899 18 biopsy biopsy NN cord-028721-x6f26ahr 1899 19 and and CC cord-028721-x6f26ahr 1899 20 spermiogram spermiogram NNP cord-028721-x6f26ahr 1899 21 . . . cord-028721-x6f26ahr 1900 1 Light light JJ cord-028721-x6f26ahr 1900 2 microscopy microscopy NN cord-028721-x6f26ahr 1900 3 immediately immediately RB cord-028721-x6f26ahr 1900 4 reveals reveal VBZ cord-028721-x6f26ahr 1900 5 whether whether IN cord-028721-x6f26ahr 1900 6 the the DT cord-028721-x6f26ahr 1900 7 lesion lesion NN cord-028721-x6f26ahr 1900 8 is be VBZ cord-028721-x6f26ahr 1900 9 focal focal JJ cord-028721-x6f26ahr 1900 10 or or CC cord-028721-x6f26ahr 1900 11 diffuse diffuse JJ cord-028721-x6f26ahr 1900 12 . . . cord-028721-x6f26ahr 1901 1 If if IN cord-028721-x6f26ahr 1901 2 focal focal JJ cord-028721-x6f26ahr 1901 3 , , , cord-028721-x6f26ahr 1901 4 the the DT cord-028721-x6f26ahr 1901 5 percentage percentage NN cord-028721-x6f26ahr 1901 6 of of IN cord-028721-x6f26ahr 1901 7 tubules tubule NNS cord-028721-x6f26ahr 1901 8 showing show VBG cord-028721-x6f26ahr 1901 9 each each DT cord-028721-x6f26ahr 1901 10 lesion lesion NN cord-028721-x6f26ahr 1901 11 ( ( -LRB- cord-028721-x6f26ahr 1901 12 Sertoli sertoli JJ cord-028721-x6f26ahr 1901 13 cell cell NN cord-028721-x6f26ahr 1901 14 - - HYPH cord-028721-x6f26ahr 1901 15 only only RB cord-028721-x6f26ahr 1901 16 , , , cord-028721-x6f26ahr 1901 17 hyalinization hyalinization NN cord-028721-x6f26ahr 1901 18 , , , cord-028721-x6f26ahr 1901 19 tubular tubular JJ cord-028721-x6f26ahr 1901 20 hypoplasia hypoplasia NN cord-028721-x6f26ahr 1901 21 , , , cord-028721-x6f26ahr 1901 22 etc etc FW cord-028721-x6f26ahr 1901 23 . . . cord-028721-x6f26ahr 1901 24 ) ) -RRB- cord-028721-x6f26ahr 1901 25 should should MD cord-028721-x6f26ahr 1901 26 be be VB cord-028721-x6f26ahr 1901 27 calculated calculate VBN cord-028721-x6f26ahr 1901 28 . . . cord-028721-x6f26ahr 1902 1 It -PRON- PRP cord-028721-x6f26ahr 1902 2 is be VBZ cord-028721-x6f26ahr 1902 3 useful useful JJ cord-028721-x6f26ahr 1902 4 to to TO cord-028721-x6f26ahr 1902 5 evaluate evaluate VB cord-028721-x6f26ahr 1902 6 elastic elastic JJ cord-028721-x6f26ahr 1902 7 fi fi NN cord-028721-x6f26ahr 1902 8 bers ber NNS cord-028721-x6f26ahr 1902 9 with with IN cord-028721-x6f26ahr 1902 10 a a DT cord-028721-x6f26ahr 1902 11 special special JJ cord-028721-x6f26ahr 1902 12 stain stain NN cord-028721-x6f26ahr 1902 13 because because IN cord-028721-x6f26ahr 1902 14 this this DT cord-028721-x6f26ahr 1902 15 highlights highlight VBZ cord-028721-x6f26ahr 1902 16 groups group NNS cord-028721-x6f26ahr 1902 17 of of IN cord-028721-x6f26ahr 1902 18 small small JJ cord-028721-x6f26ahr 1902 19 tubules tubule NNS cord-028721-x6f26ahr 1902 20 that that WDT cord-028721-x6f26ahr 1902 21 may may MD cord-028721-x6f26ahr 1902 22 be be VB cord-028721-x6f26ahr 1902 23 missed miss VBN cord-028721-x6f26ahr 1902 24 with with IN cord-028721-x6f26ahr 1902 25 hematoxylin hematoxylin NNP cord-028721-x6f26ahr 1902 26 and and CC cord-028721-x6f26ahr 1902 27 eosin eosin NNP cord-028721-x6f26ahr 1902 28 . . . cord-028721-x6f26ahr 1903 1 A a DT cord-028721-x6f26ahr 1903 2 minimum minimum NN cord-028721-x6f26ahr 1903 3 of of IN cord-028721-x6f26ahr 1903 4 30 30 CD cord-028721-x6f26ahr 1903 5 cross cross NN cord-028721-x6f26ahr 1903 6 - - JJ cord-028721-x6f26ahr 1903 7 sectioned section VBN cord-028721-x6f26ahr 1903 8 tubules tubule NNS cord-028721-x6f26ahr 1903 9 should should MD cord-028721-x6f26ahr 1903 10 be be VB cord-028721-x6f26ahr 1903 11 studied study VBN cord-028721-x6f26ahr 1903 12 ( ( -LRB- cord-028721-x6f26ahr 1903 13 this this DT cord-028721-x6f26ahr 1903 14 is be VBZ cord-028721-x6f26ahr 1903 15 usually usually RB cord-028721-x6f26ahr 1903 16 possible possible JJ cord-028721-x6f26ahr 1903 17 when when WRB cord-028721-x6f26ahr 1903 18 fi fi NNP cord-028721-x6f26ahr 1903 19 ve ve VBD cord-028721-x6f26ahr 1903 20 or or CC cord-028721-x6f26ahr 1903 21 six six CD cord-028721-x6f26ahr 1903 22 histological histological JJ cord-028721-x6f26ahr 1903 23 sections section NNS cord-028721-x6f26ahr 1903 24 are be VBP cord-028721-x6f26ahr 1903 25 available available JJ cord-028721-x6f26ahr 1903 26 ) ) -RRB- cord-028721-x6f26ahr 1903 27 . . . cord-028721-x6f26ahr 1904 1 The the DT cord-028721-x6f26ahr 1904 2 diameter diameter NN cord-028721-x6f26ahr 1904 3 of of IN cord-028721-x6f26ahr 1904 4 each each DT cord-028721-x6f26ahr 1904 5 tubule tubule NN cord-028721-x6f26ahr 1904 6 should should MD cord-028721-x6f26ahr 1904 7 be be VB cord-028721-x6f26ahr 1904 8 measured measure VBN cord-028721-x6f26ahr 1904 9 , , , cord-028721-x6f26ahr 1904 10 and and CC cord-028721-x6f26ahr 1904 11 the the DT cord-028721-x6f26ahr 1904 12 number number NN cord-028721-x6f26ahr 1904 13 of of IN cord-028721-x6f26ahr 1904 14 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1904 15 , , , cord-028721-x6f26ahr 1904 16 primary primary JJ cord-028721-x6f26ahr 1904 17 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 1904 18 , , , cord-028721-x6f26ahr 1904 19 young young JJ cord-028721-x6f26ahr 1904 20 spermatids spermatid NNS cord-028721-x6f26ahr 1904 21 ( ( -LRB- cord-028721-x6f26ahr 1904 22 also also RB cord-028721-x6f26ahr 1904 23 called call VBN cord-028721-x6f26ahr 1904 24 round round JJ cord-028721-x6f26ahr 1904 25 spermatids spermatid NNS cord-028721-x6f26ahr 1904 26 or or CC cord-028721-x6f26ahr 1904 27 S S NNP cord-028721-x6f26ahr 1904 28 a a NNP cord-028721-x6f26ahr 1904 29 + + CC cord-028721-x6f26ahr 1904 30 S s NN cord-028721-x6f26ahr 1904 31 b b NN cord-028721-x6f26ahr 1904 32 spermatids spermatids NNP cord-028721-x6f26ahr 1904 33 ) ) -RRB- cord-028721-x6f26ahr 1904 34 , , , cord-028721-x6f26ahr 1904 35 mature mature NNP cord-028721-x6f26ahr 1904 36 spermatids spermatid NNS cord-028721-x6f26ahr 1904 37 ( ( -LRB- cord-028721-x6f26ahr 1904 38 also also RB cord-028721-x6f26ahr 1904 39 called call VBN cord-028721-x6f26ahr 1904 40 elongated elongated JJ cord-028721-x6f26ahr 1904 41 or or CC cord-028721-x6f26ahr 1904 42 S s NN cord-028721-x6f26ahr 1904 43 c c NN cord-028721-x6f26ahr 1904 44 + + CC cord-028721-x6f26ahr 1904 45 S s NN cord-028721-x6f26ahr 1904 46 d d NNP cord-028721-x6f26ahr 1904 47 spermatids spermatids NNP cord-028721-x6f26ahr 1904 48 ) ) -RRB- cord-028721-x6f26ahr 1904 49 , , , cord-028721-x6f26ahr 1904 50 Sertoli Sertoli NNP cord-028721-x6f26ahr 1904 51 cells cell NNS cord-028721-x6f26ahr 1904 52 , , , cord-028721-x6f26ahr 1904 53 and and CC cord-028721-x6f26ahr 1904 54 , , , cord-028721-x6f26ahr 1904 55 in in IN cord-028721-x6f26ahr 1904 56 some some DT cord-028721-x6f26ahr 1904 57 cases case NNS cord-028721-x6f26ahr 1904 58 , , , cord-028721-x6f26ahr 1904 59 peritubular peritubular NNP cord-028721-x6f26ahr 1904 60 cells cell NNS cord-028721-x6f26ahr 1904 61 counted count VBD cord-028721-x6f26ahr 1904 62 . . . cord-028721-x6f26ahr 1905 1 The the DT cord-028721-x6f26ahr 1905 2 presence presence NN cord-028721-x6f26ahr 1905 3 of of IN cord-028721-x6f26ahr 1905 4 tubular tubular JJ cord-028721-x6f26ahr 1905 5 diverticula diverticulum NNS cord-028721-x6f26ahr 1905 6 , , , cord-028721-x6f26ahr 1905 7 879 879 CD cord-028721-x6f26ahr 1905 8 _SP cord-028721-x6f26ahr 1906 1 The the DT cord-028721-x6f26ahr 1906 2 most most RBS cord-028721-x6f26ahr 1906 3 frequently frequently RB cord-028721-x6f26ahr 1906 4 observed observed JJ cord-028721-x6f26ahr 1906 5 lesions lesion NNS cord-028721-x6f26ahr 1906 6 are be VBP cord-028721-x6f26ahr 1906 7 Sertoli sertoli JJ cord-028721-x6f26ahr 1906 8 cell cell NN cord-028721-x6f26ahr 1906 9 - - HYPH cord-028721-x6f26ahr 1906 10 only only RB cord-028721-x6f26ahr 1906 11 tubules tubule NNS cord-028721-x6f26ahr 1906 12 , , , cord-028721-x6f26ahr 1906 13 tubular tubular JJ cord-028721-x6f26ahr 1906 14 hyalinization hyalinization NN cord-028721-x6f26ahr 1906 15 , , , cord-028721-x6f26ahr 1906 16 alterations alteration NNS cord-028721-x6f26ahr 1906 17 in in IN cord-028721-x6f26ahr 1906 18 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1906 19 in in IN cord-028721-x6f26ahr 1906 20 either either CC cord-028721-x6f26ahr 1906 21 the the DT cord-028721-x6f26ahr 1906 22 adluminal adluminal NNP cord-028721-x6f26ahr 1906 23 or or CC cord-028721-x6f26ahr 1906 24 the the DT cord-028721-x6f26ahr 1906 25 basal basal NN cord-028721-x6f26ahr 1906 26 compartments compartment NNS cord-028721-x6f26ahr 1906 27 of of IN cord-028721-x6f26ahr 1906 28 seminiferous seminiferous JJ cord-028721-x6f26ahr 1906 29 tubules tubule NNS cord-028721-x6f26ahr 1906 30 , , , cord-028721-x6f26ahr 1906 31 and and CC cord-028721-x6f26ahr 1906 32 mixed mix VBD cord-028721-x6f26ahr 1906 33 tubular tubular JJ cord-028721-x6f26ahr 1906 34 atrophy atrophy NN cord-028721-x6f26ahr 1906 35 . . . cord-028721-x6f26ahr 1907 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1907 2 cell cell NN cord-028721-x6f26ahr 1907 3 - - HYPH cord-028721-x6f26ahr 1907 4 only only RB cord-028721-x6f26ahr 1907 5 syndrome syndrome NN cord-028721-x6f26ahr 1907 6 includes include VBZ cord-028721-x6f26ahr 1907 7 all all DT cord-028721-x6f26ahr 1907 8 azoospermias azoospermia NNS cord-028721-x6f26ahr 1907 9 in in IN cord-028721-x6f26ahr 1907 10 which which WDT cord-028721-x6f26ahr 1907 11 the the DT cord-028721-x6f26ahr 1907 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 1907 13 epithelium epithelium NN cord-028721-x6f26ahr 1907 14 consists consist VBZ cord-028721-x6f26ahr 1907 15 only only RB cord-028721-x6f26ahr 1907 16 of of IN cord-028721-x6f26ahr 1907 17 Sertoli Sertoli NNP cord-028721-x6f26ahr 1907 18 cells cell NNS cord-028721-x6f26ahr 1907 19 . . . cord-028721-x6f26ahr 1908 1 To to TO cord-028721-x6f26ahr 1908 2 better well RBR cord-028721-x6f26ahr 1908 3 understand understand VB cord-028721-x6f26ahr 1908 4 this this DT cord-028721-x6f26ahr 1908 5 syndrome syndrome NN cord-028721-x6f26ahr 1908 6 , , , cord-028721-x6f26ahr 1908 7 it -PRON- PRP cord-028721-x6f26ahr 1908 8 is be VBZ cord-028721-x6f26ahr 1908 9 necessary necessary JJ cord-028721-x6f26ahr 1908 10 to to TO cord-028721-x6f26ahr 1908 11 consider consider VB cord-028721-x6f26ahr 1908 12 the the DT cord-028721-x6f26ahr 1908 13 morphological morphological JJ cord-028721-x6f26ahr 1908 14 and and CC cord-028721-x6f26ahr 1908 15 functional functional JJ cord-028721-x6f26ahr 1908 16 changes change NNS cord-028721-x6f26ahr 1908 17 induced induce VBN cord-028721-x6f26ahr 1908 18 in in IN cord-028721-x6f26ahr 1908 19 the the DT cord-028721-x6f26ahr 1908 20 Sertoli sertoli JJ cord-028721-x6f26ahr 1908 21 cell cell NN cord-028721-x6f26ahr 1908 22 by by IN cord-028721-x6f26ahr 1908 23 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 1908 24 gonadotropin gonadotropin NN cord-028721-x6f26ahr 1908 25 secretion secretion NN cord-028721-x6f26ahr 1908 26 during during IN cord-028721-x6f26ahr 1908 27 puberty puberty NN cord-028721-x6f26ahr 1908 28 . . . cord-028721-x6f26ahr 1909 1 During during IN cord-028721-x6f26ahr 1909 2 childhood childhood NN cord-028721-x6f26ahr 1909 3 , , , cord-028721-x6f26ahr 1909 4 Sertoli sertoli JJ cord-028721-x6f26ahr 1909 5 cells cell NNS cord-028721-x6f26ahr 1909 6 are be VBP cord-028721-x6f26ahr 1909 7 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 1909 8 ed ed NN cord-028721-x6f26ahr 1909 9 and and CC cord-028721-x6f26ahr 1909 10 their -PRON- PRP$ cord-028721-x6f26ahr 1909 11 nuclei nucleus NNS cord-028721-x6f26ahr 1909 12 are be VBP cord-028721-x6f26ahr 1909 13 dark dark JJ cord-028721-x6f26ahr 1909 14 , , , cord-028721-x6f26ahr 1909 15 small small JJ cord-028721-x6f26ahr 1909 16 , , , cord-028721-x6f26ahr 1909 17 and and CC cord-028721-x6f26ahr 1909 18 round round JJ cord-028721-x6f26ahr 1909 19 or or CC cord-028721-x6f26ahr 1909 20 elongated elongated JJ cord-028721-x6f26ahr 1909 21 , , , cord-028721-x6f26ahr 1909 22 with with IN cord-028721-x6f26ahr 1909 23 regular regular JJ cord-028721-x6f26ahr 1909 24 outlines outline NNS cord-028721-x6f26ahr 1909 25 and and CC cord-028721-x6f26ahr 1909 26 one one CD cord-028721-x6f26ahr 1909 27 or or CC cord-028721-x6f26ahr 1909 28 two two CD cord-028721-x6f26ahr 1909 29 small small JJ cord-028721-x6f26ahr 1909 30 peripherally peripherally RB cord-028721-x6f26ahr 1909 31 placed place VBD cord-028721-x6f26ahr 1909 32 nucleoli nucleoli NNP cord-028721-x6f26ahr 1909 33 . . . cord-028721-x6f26ahr 1910 1 The the DT cord-028721-x6f26ahr 1910 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1910 3 lacks lack VBZ cord-028721-x6f26ahr 1910 4 specialized specialized JJ cord-028721-x6f26ahr 1910 5 organelles organelle NNS cord-028721-x6f26ahr 1910 6 . . . cord-028721-x6f26ahr 1911 1 881 881 CD cord-028721-x6f26ahr 1911 2 Adult Adult NNP cord-028721-x6f26ahr 1911 3 Sertoli Sertoli NNP cord-028721-x6f26ahr 1911 4 cells cell NNS cord-028721-x6f26ahr 1911 5 have have VBP cord-028721-x6f26ahr 1911 6 characteristically characteristically RB cord-028721-x6f26ahr 1911 7 pale pale JJ cord-028721-x6f26ahr 1911 8 , , , cord-028721-x6f26ahr 1911 9 triangular triangular JJ cord-028721-x6f26ahr 1911 10 nuclei nucleus NNS cord-028721-x6f26ahr 1911 11 with with IN cord-028721-x6f26ahr 1911 12 irregular irregular JJ cord-028721-x6f26ahr 1911 13 , , , cord-028721-x6f26ahr 1911 14 indented indented JJ cord-028721-x6f26ahr 1911 15 outlines outline NNS cord-028721-x6f26ahr 1911 16 . . . cord-028721-x6f26ahr 1912 1 The the DT cord-028721-x6f26ahr 1912 2 nucleoli nucleolus NNS cord-028721-x6f26ahr 1912 3 are be VBP cord-028721-x6f26ahr 1912 4 large large JJ cord-028721-x6f26ahr 1912 5 and and CC cord-028721-x6f26ahr 1912 6 have have VBP cord-028721-x6f26ahr 1912 7 tripartite tripartite JJ cord-028721-x6f26ahr 1912 8 structures structure NNS cord-028721-x6f26ahr 1912 9 . . . cord-028721-x6f26ahr 1913 1 The the DT cord-028721-x6f26ahr 1913 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1913 3 contains contain VBZ cord-028721-x6f26ahr 1913 4 abundant abundant JJ cord-028721-x6f26ahr 1913 5 smooth smooth JJ cord-028721-x6f26ahr 1913 6 endoplasmic endoplasmic NN cord-028721-x6f26ahr 1913 7 reticulum reticulum NN cord-028721-x6f26ahr 1913 8 and and CC cord-028721-x6f26ahr 1913 9 specialized specialized JJ cord-028721-x6f26ahr 1913 10 structures structure NNS cord-028721-x6f26ahr 1913 11 , , , cord-028721-x6f26ahr 1913 12 including include VBG cord-028721-x6f26ahr 1913 13 annulate annulate NN cord-028721-x6f26ahr 1913 14 lamellae lamella NNS cord-028721-x6f26ahr 1913 15 , , , cord-028721-x6f26ahr 1913 16 Charcot Charcot NNP cord-028721-x6f26ahr 1913 17 - - HYPH cord-028721-x6f26ahr 1913 18 Böttcher Böttcher NNP cord-028721-x6f26ahr 1913 19 crystals crystal NNS cord-028721-x6f26ahr 1913 20 , , , cord-028721-x6f26ahr 1913 21 and and CC cord-028721-x6f26ahr 1913 22 specialized specialized JJ cord-028721-x6f26ahr 1913 23 junctional junctional JJ cord-028721-x6f26ahr 1913 24 complexes complex NNS cord-028721-x6f26ahr 1913 25 with with IN cord-028721-x6f26ahr 1913 26 other other JJ cord-028721-x6f26ahr 1913 27 Sertoli Sertoli NNP cord-028721-x6f26ahr 1913 28 cells cell NNS cord-028721-x6f26ahr 1913 29 . . . cord-028721-x6f26ahr 1914 1 The the DT cord-028721-x6f26ahr 1914 2 pubertal pubertal JJ cord-028721-x6f26ahr 1914 3 increase increase NN cord-028721-x6f26ahr 1914 4 in in IN cord-028721-x6f26ahr 1914 5 length length NN cord-028721-x6f26ahr 1914 6 and and CC cord-028721-x6f26ahr 1914 7 width width NN cord-028721-x6f26ahr 1914 8 of of IN cord-028721-x6f26ahr 1914 9 the the DT cord-028721-x6f26ahr 1914 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 1914 11 tubules tubule NNS cord-028721-x6f26ahr 1914 12 replaces replace VBZ cord-028721-x6f26ahr 1914 13 the the DT cord-028721-x6f26ahr 1914 14 infantile infantile JJ cord-028721-x6f26ahr 1914 15 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 1914 16 ed ed NN cord-028721-x6f26ahr 1914 17 pattern pattern NN cord-028721-x6f26ahr 1914 18 with with IN cord-028721-x6f26ahr 1914 19 a a DT cord-028721-x6f26ahr 1914 20 simple simple JJ cord-028721-x6f26ahr 1914 21 columnar columnar JJ cord-028721-x6f26ahr 1914 22 distribution distribution NN cord-028721-x6f26ahr 1914 23 . . . cord-028721-x6f26ahr 1915 1 Five five CD cord-028721-x6f26ahr 1915 2 variants variant NNS cord-028721-x6f26ahr 1915 3 of of IN cord-028721-x6f26ahr 1915 4 the the DT cord-028721-x6f26ahr 1915 5 Sertoli sertoli JJ cord-028721-x6f26ahr 1915 6 cell cell NN cord-028721-x6f26ahr 1915 7 - - HYPH cord-028721-x6f26ahr 1915 8 only only JJ cord-028721-x6f26ahr 1915 9 syndrome syndrome NN cord-028721-x6f26ahr 1915 10 are be VBP cord-028721-x6f26ahr 1915 11 identifi identifi VBN cord-028721-x6f26ahr 1915 12 ed ed NN cord-028721-x6f26ahr 1915 13 by by IN cord-028721-x6f26ahr 1915 14 Sertoli sertoli JJ cord-028721-x6f26ahr 1915 15 cell cell NN cord-028721-x6f26ahr 1915 16 morphology morphology NN cord-028721-x6f26ahr 1915 17 , , , cord-028721-x6f26ahr 1915 18 the the DT cord-028721-x6f26ahr 1915 19 degree degree NN cord-028721-x6f26ahr 1915 20 of of IN cord-028721-x6f26ahr 1915 21 development development NN cord-028721-x6f26ahr 1915 22 of of IN cord-028721-x6f26ahr 1915 23 the the DT cord-028721-x6f26ahr 1915 24 seminiferous seminiferous JJ cord-028721-x6f26ahr 1915 25 tubules tubule NNS cord-028721-x6f26ahr 1915 26 , , , cord-028721-x6f26ahr 1915 27 and and CC cord-028721-x6f26ahr 1915 28 the the DT cord-028721-x6f26ahr 1915 29 presence presence NN cord-028721-x6f26ahr 1915 30 or or CC cord-028721-x6f26ahr 1915 31 absence absence NN cord-028721-x6f26ahr 1915 32 of of IN cord-028721-x6f26ahr 1915 33 interstitial interstitial JJ cord-028721-x6f26ahr 1915 34 lesions lesion NNS cord-028721-x6f26ahr 1915 35 . . . cord-028721-x6f26ahr 1916 1 882 882 CD cord-028721-x6f26ahr 1917 1 These these DT cord-028721-x6f26ahr 1917 2 variants variant NNS cord-028721-x6f26ahr 1917 3 are be VBP cord-028721-x6f26ahr 1917 4 designated designate VBN cord-028721-x6f26ahr 1917 5 by by IN cord-028721-x6f26ahr 1917 6 the the DT cord-028721-x6f26ahr 1917 7 appearance appearance NN cord-028721-x6f26ahr 1917 8 of of IN cord-028721-x6f26ahr 1917 9 the the DT cord-028721-x6f26ahr 1917 10 predominant predominant JJ cord-028721-x6f26ahr 1917 11 Sertoli sertoli JJ cord-028721-x6f26ahr 1917 12 cell cell NN cord-028721-x6f26ahr 1917 13 population population NN cord-028721-x6f26ahr 1917 14 : : : cord-028721-x6f26ahr 1917 15 immature immature JJ cord-028721-x6f26ahr 1917 16 Sertoli sertoli JJ cord-028721-x6f26ahr 1917 17 cells cell NNS cord-028721-x6f26ahr 1917 18 , , , cord-028721-x6f26ahr 1917 19 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1917 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 1917 21 cells cell NNS cord-028721-x6f26ahr 1917 22 , , , cord-028721-x6f26ahr 1917 23 adult adult NN cord-028721-x6f26ahr 1917 24 Sertoli Sertoli NNP cord-028721-x6f26ahr 1917 25 cells cell NNS cord-028721-x6f26ahr 1917 26 , , , cord-028721-x6f26ahr 1917 27 involuting involute VBG cord-028721-x6f26ahr 1917 28 Sertoli sertoli JJ cord-028721-x6f26ahr 1917 29 cells cell NNS cord-028721-x6f26ahr 1917 30 , , , cord-028721-x6f26ahr 1917 31 and and CC cord-028721-x6f26ahr 1917 32 dedifferentiated dedifferentiate VBN cord-028721-x6f26ahr 1917 33 Sertoli Sertoli NNP cord-028721-x6f26ahr 1917 34 cells cell NNS cord-028721-x6f26ahr 1917 35 ( ( -LRB- cord-028721-x6f26ahr 1917 36 Fig Fig NNP cord-028721-x6f26ahr 1917 37 . . . cord-028721-x6f26ahr 1917 38 12 12 CD cord-028721-x6f26ahr 1917 39 - - SYM cord-028721-x6f26ahr 1917 40 88 88 CD cord-028721-x6f26ahr 1917 41 ) ) -RRB- cord-028721-x6f26ahr 1917 42 . . . cord-028721-x6f26ahr 1918 1 Each each DT cord-028721-x6f26ahr 1918 2 type type NN cord-028721-x6f26ahr 1918 3 is be VBZ cord-028721-x6f26ahr 1918 4 associated associate VBN cord-028721-x6f26ahr 1918 5 with with IN cord-028721-x6f26ahr 1918 6 other other JJ cord-028721-x6f26ahr 1918 7 tubular tubular JJ cord-028721-x6f26ahr 1918 8 and and CC cord-028721-x6f26ahr 1918 9 interstitial interstitial JJ cord-028721-x6f26ahr 1918 10 alterations alteration NNS cord-028721-x6f26ahr 1918 11 ( ( -LRB- cord-028721-x6f26ahr 1918 12 Table Table NNP cord-028721-x6f26ahr 1918 13 12 12 CD cord-028721-x6f26ahr 1918 14 - - SYM cord-028721-x6f26ahr 1918 15 7 7 CD cord-028721-x6f26ahr 1918 16 ) ) -RRB- cord-028721-x6f26ahr 1918 17 . . . cord-028721-x6f26ahr 1919 1 The the DT cord-028721-x6f26ahr 1919 2 most most RBS cord-028721-x6f26ahr 1919 3 frequent frequent JJ cord-028721-x6f26ahr 1919 4 types type NNS cord-028721-x6f26ahr 1919 5 of of IN cord-028721-x6f26ahr 1919 6 Sertoli sertoli JJ cord-028721-x6f26ahr 1919 7 cell cell NN cord-028721-x6f26ahr 1919 8 - - HYPH cord-028721-x6f26ahr 1919 9 only only JJ cord-028721-x6f26ahr 1919 10 syndrome syndrome NN cord-028721-x6f26ahr 1919 11 in in IN cord-028721-x6f26ahr 1919 12 infertility infertility NN cord-028721-x6f26ahr 1919 13 patients patient NNS cord-028721-x6f26ahr 1919 14 are be VBP cord-028721-x6f26ahr 1919 15 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1919 16 Sertoli Sertoli NNP cord-028721-x6f26ahr 1919 17 cells cell NNS cord-028721-x6f26ahr 1919 18 , , , cord-028721-x6f26ahr 1919 19 adult adult NN cord-028721-x6f26ahr 1919 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 1919 21 cells cell NNS cord-028721-x6f26ahr 1919 22 , , , cord-028721-x6f26ahr 1919 23 and and CC cord-028721-x6f26ahr 1919 24 involuting involute VBG cord-028721-x6f26ahr 1919 25 Sertoli sertoli JJ cord-028721-x6f26ahr 1919 26 cells cell NNS cord-028721-x6f26ahr 1919 27 . . . cord-028721-x6f26ahr 1920 1 The the DT cord-028721-x6f26ahr 1920 2 clinical clinical JJ cord-028721-x6f26ahr 1920 3 manifestations manifestation NNS cord-028721-x6f26ahr 1920 4 are be VBP cord-028721-x6f26ahr 1920 5 similar similar JJ cord-028721-x6f26ahr 1920 6 , , , cord-028721-x6f26ahr 1920 7 including include VBG cord-028721-x6f26ahr 1920 8 normal normal JJ cord-028721-x6f26ahr 1920 9 external external JJ cord-028721-x6f26ahr 1920 10 genitalia genitalia NNS cord-028721-x6f26ahr 1920 11 , , , cord-028721-x6f26ahr 1920 12 welldeveloped welldeveloped JJ cord-028721-x6f26ahr 1920 13 secondary secondary JJ cord-028721-x6f26ahr 1920 14 male male JJ cord-028721-x6f26ahr 1920 15 characteristics characteristic NNS cord-028721-x6f26ahr 1920 16 , , , cord-028721-x6f26ahr 1920 17 azoospermia azoospermia NN cord-028721-x6f26ahr 1920 18 , , , cord-028721-x6f26ahr 1920 19 elevated elevated JJ cord-028721-x6f26ahr 1920 20 serum serum NN cord-028721-x6f26ahr 1920 21 FSH fsh NN cord-028721-x6f26ahr 1920 22 level level NN cord-028721-x6f26ahr 1920 23 , , , cord-028721-x6f26ahr 1920 24 normal normal JJ cord-028721-x6f26ahr 1920 25 or or CC cord-028721-x6f26ahr 1920 26 elevated elevated JJ cord-028721-x6f26ahr 1920 27 serum serum NN cord-028721-x6f26ahr 1920 28 LH lh NN cord-028721-x6f26ahr 1920 29 level level NN cord-028721-x6f26ahr 1920 30 , , , cord-028721-x6f26ahr 1920 31 and and CC cord-028721-x6f26ahr 1920 32 normal normal JJ cord-028721-x6f26ahr 1920 33 or or CC cord-028721-x6f26ahr 1920 34 slightly slightly RB cord-028721-x6f26ahr 1920 35 low low JJ cord-028721-x6f26ahr 1920 36 testosterone testosterone NN cord-028721-x6f26ahr 1920 37 . . . cord-028721-x6f26ahr 1921 1 These these DT cord-028721-x6f26ahr 1921 2 clinical clinical JJ cord-028721-x6f26ahr 1921 3 and and CC cord-028721-x6f26ahr 1921 4 histologic histologic JJ cord-028721-x6f26ahr 1921 5 features feature NNS cord-028721-x6f26ahr 1921 6 were be VBD cord-028721-x6f26ahr 1921 7 long long RB cord-028721-x6f26ahr 1921 8 thought think VBN cord-028721-x6f26ahr 1921 9 to to TO cord-028721-x6f26ahr 1921 10 constitute constitute VB cord-028721-x6f26ahr 1921 11 a a DT cord-028721-x6f26ahr 1921 12 single single JJ cord-028721-x6f26ahr 1921 13 syndrome syndrome NN cord-028721-x6f26ahr 1921 14 , , , cord-028721-x6f26ahr 1921 15 Del Del NNP cord-028721-x6f26ahr 1921 16 Castillo Castillo NNP cord-028721-x6f26ahr 1921 17 's 's POS cord-028721-x6f26ahr 1921 18 syndrome syndrome NN cord-028721-x6f26ahr 1921 19 , , , cord-028721-x6f26ahr 1921 20 but but CC cord-028721-x6f26ahr 1921 21 recent recent JJ cord-028721-x6f26ahr 1921 22 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 1921 23 , , , cord-028721-x6f26ahr 1921 24 histochemical histochemical JJ cord-028721-x6f26ahr 1921 25 , , , cord-028721-x6f26ahr 1921 26 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 1921 27 , , , cord-028721-x6f26ahr 1921 28 and and CC cord-028721-x6f26ahr 1921 29 cytogenetic cytogenetic JJ cord-028721-x6f26ahr 1921 30 studies study NNS cord-028721-x6f26ahr 1921 31 have have VBP cord-028721-x6f26ahr 1921 32 shown show VBN cord-028721-x6f26ahr 1921 33 that that IN cord-028721-x6f26ahr 1921 34 this this DT cord-028721-x6f26ahr 1921 35 results result VBZ cord-028721-x6f26ahr 1921 36 from from IN cord-028721-x6f26ahr 1921 37 a a DT cord-028721-x6f26ahr 1921 38 variety variety NN cord-028721-x6f26ahr 1921 39 of of IN cord-028721-x6f26ahr 1921 40 syndromes syndrome NNS cord-028721-x6f26ahr 1921 41 that that WDT cord-028721-x6f26ahr 1921 42 may may MD cord-028721-x6f26ahr 1921 43 have have VB cord-028721-x6f26ahr 1921 44 primary primary JJ cord-028721-x6f26ahr 1921 45 or or CC cord-028721-x6f26ahr 1921 46 secondary secondary JJ cord-028721-x6f26ahr 1921 47 causes cause NNS cord-028721-x6f26ahr 1921 48 ( ( -LRB- cord-028721-x6f26ahr 1921 49 Table Table NNP cord-028721-x6f26ahr 1921 50 _SP cord-028721-x6f26ahr 1921 51 12 12 CD cord-028721-x6f26ahr 1921 52 - - SYM cord-028721-x6f26ahr 1921 53 7 7 CD cord-028721-x6f26ahr 1921 54 ) ) -RRB- cord-028721-x6f26ahr 1921 55 . . . cord-028721-x6f26ahr 1922 1 [ [ -LRB- cord-028721-x6f26ahr 1922 2 883 883 CD cord-028721-x6f26ahr 1922 3 ] ] -RRB- cord-028721-x6f26ahr 1922 4 [ [ -LRB- cord-028721-x6f26ahr 1922 5 884 884 CD cord-028721-x6f26ahr 1922 6 ] ] -RRB- cord-028721-x6f26ahr 1922 7 [ [ -LRB- cord-028721-x6f26ahr 1922 8 885 885 CD cord-028721-x6f26ahr 1922 9 ] ] -RRB- cord-028721-x6f26ahr 1923 1 [ [ -LRB- cord-028721-x6f26ahr 1923 2 886 886 CD cord-028721-x6f26ahr 1923 3 ] ] -RRB- cord-028721-x6f26ahr 1924 1 [ [ -LRB- cord-028721-x6f26ahr 1924 2 887 887 CD cord-028721-x6f26ahr 1924 3 ] ] -RRB- cord-028721-x6f26ahr 1925 1 Some some DT cord-028721-x6f26ahr 1925 2 patients patient NNS cord-028721-x6f26ahr 1925 3 with with IN cord-028721-x6f26ahr 1925 4 the the DT cord-028721-x6f26ahr 1925 5 adult adult NN cord-028721-x6f26ahr 1925 6 or or CC cord-028721-x6f26ahr 1925 7 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1925 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 1925 9 cellonly cellonly NN cord-028721-x6f26ahr 1925 10 syndrome syndrome NN cord-028721-x6f26ahr 1925 11 variants variant NNS cord-028721-x6f26ahr 1925 12 have have VBP cord-028721-x6f26ahr 1925 13 a a DT cord-028721-x6f26ahr 1925 14 few few JJ cord-028721-x6f26ahr 1925 15 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 1925 16 in in IN cord-028721-x6f26ahr 1925 17 their -PRON- PRP$ cord-028721-x6f26ahr 1925 18 spermiograms spermiogram NNS cord-028721-x6f26ahr 1925 19 . . . cord-028721-x6f26ahr 1926 1 This this DT cord-028721-x6f26ahr 1926 2 discrepancy discrepancy NN cord-028721-x6f26ahr 1926 3 between between IN cord-028721-x6f26ahr 1926 4 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 1926 5 and and CC cord-028721-x6f26ahr 1926 6 the the DT cord-028721-x6f26ahr 1926 7 biopsy biopsy NNP cord-028721-x6f26ahr 1926 8 histology histology NN cord-028721-x6f26ahr 1926 9 is be VBZ cord-028721-x6f26ahr 1926 10 caused cause VBN cord-028721-x6f26ahr 1926 11 by by IN cord-028721-x6f26ahr 1926 12 the the DT cord-028721-x6f26ahr 1926 13 presence presence NN cord-028721-x6f26ahr 1926 14 of of IN cord-028721-x6f26ahr 1926 15 some some DT cord-028721-x6f26ahr 1926 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 1926 17 tubules tubule NNS cord-028721-x6f26ahr 1926 18 with with IN cord-028721-x6f26ahr 1926 19 complete complete JJ cord-028721-x6f26ahr 1926 20 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1926 21 elsewhere elsewhere RB cord-028721-x6f26ahr 1926 22 in in IN cord-028721-x6f26ahr 1926 23 the the DT cord-028721-x6f26ahr 1926 24 testicular testicular JJ cord-028721-x6f26ahr 1926 25 parenchyma parenchyma NN cord-028721-x6f26ahr 1926 26 . . . cord-028721-x6f26ahr 1927 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1927 2 cell cell NN cord-028721-x6f26ahr 1927 3 - - HYPH cord-028721-x6f26ahr 1927 4 only only JJ cord-028721-x6f26ahr 1927 5 syndrome syndrome NN cord-028721-x6f26ahr 1927 6 with with IN cord-028721-x6f26ahr 1927 7 immature immature JJ cord-028721-x6f26ahr 1927 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 1927 9 cells cell NNS cord-028721-x6f26ahr 1928 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1928 2 cells cell NNS cord-028721-x6f26ahr 1928 3 in in IN cord-028721-x6f26ahr 1928 4 adult adult NN cord-028721-x6f26ahr 1928 5 testes testis NNS cord-028721-x6f26ahr 1928 6 with with IN cord-028721-x6f26ahr 1928 7 this this DT cord-028721-x6f26ahr 1928 8 variant variant NN cord-028721-x6f26ahr 1928 9 of of IN cord-028721-x6f26ahr 1928 10 Sertoli Sertoli NNP cord-028721-x6f26ahr 1928 11 cell cell NN cord-028721-x6f26ahr 1928 12 - - HYPH cord-028721-x6f26ahr 1928 13 only only JJ cord-028721-x6f26ahr 1928 14 syndrome syndrome NN cord-028721-x6f26ahr 1928 15 have have VBP cord-028721-x6f26ahr 1928 16 an an DT cord-028721-x6f26ahr 1928 17 immature immature JJ cord-028721-x6f26ahr 1928 18 prepubertal prepubertal JJ cord-028721-x6f26ahr 1928 19 appearance appearance NN cord-028721-x6f26ahr 1928 20 with with IN cord-028721-x6f26ahr 1928 21 pseudostratifi pseudostratifi NNP cord-028721-x6f26ahr 1928 22 cation cation NNP cord-028721-x6f26ahr 1928 23 . . . cord-028721-x6f26ahr 1929 1 The the DT cord-028721-x6f26ahr 1929 2 number number NN cord-028721-x6f26ahr 1929 3 of of IN cord-028721-x6f26ahr 1929 4 cells cell NNS cord-028721-x6f26ahr 1929 5 per per IN cord-028721-x6f26ahr 1929 6 cross cross JJ cord-028721-x6f26ahr 1929 7 - - JJ cord-028721-x6f26ahr 1929 8 sectioned sectioned JJ cord-028721-x6f26ahr 1929 9 tubule tubule NN cord-028721-x6f26ahr 1929 10 is be VBZ cord-028721-x6f26ahr 1929 11 greater great JJR cord-028721-x6f26ahr 1929 12 than than IN cord-028721-x6f26ahr 1929 13 normal normal JJ cord-028721-x6f26ahr 1929 14 . . . cord-028721-x6f26ahr 1930 1 Other other JJ cord-028721-x6f26ahr 1930 2 tubular tubular JJ cord-028721-x6f26ahr 1930 3 and and CC cord-028721-x6f26ahr 1930 4 interstitial interstitial JJ cord-028721-x6f26ahr 1930 5 features feature NNS cord-028721-x6f26ahr 1930 6 suggest suggest VBP cord-028721-x6f26ahr 1930 7 immaturity immaturity NN cord-028721-x6f26ahr 1930 8 , , , cord-028721-x6f26ahr 1930 9 including include VBG cord-028721-x6f26ahr 1930 10 small small JJ cord-028721-x6f26ahr 1930 11 tubular tubular JJ cord-028721-x6f26ahr 1930 12 diame diame NN cord-028721-x6f26ahr 1930 13 - - HYPH cord-028721-x6f26ahr 1930 14 ters ters NNPS cord-028721-x6f26ahr 1930 15 ( ( -LRB- cord-028721-x6f26ahr 1930 16 < < XX cord-028721-x6f26ahr 1930 17 80 80 CD cord-028721-x6f26ahr 1930 18 µm µm CD cord-028721-x6f26ahr 1930 19 ) ) -RRB- cord-028721-x6f26ahr 1930 20 , , , cord-028721-x6f26ahr 1930 21 tubules tubule NNS cord-028721-x6f26ahr 1930 22 lacking lack VBG cord-028721-x6f26ahr 1930 23 central central JJ cord-028721-x6f26ahr 1930 24 lumina lumina NNP cord-028721-x6f26ahr 1930 25 , , , cord-028721-x6f26ahr 1930 26 thin thin JJ cord-028721-x6f26ahr 1930 27 lamina lamina NN cord-028721-x6f26ahr 1930 28 propria propria NN cord-028721-x6f26ahr 1930 29 lacking lack VBG cord-028721-x6f26ahr 1930 30 elastic elastic JJ cord-028721-x6f26ahr 1930 31 fi fi NN cord-028721-x6f26ahr 1930 32 bers ber NNS cord-028721-x6f26ahr 1930 33 , , , cord-028721-x6f26ahr 1930 34 and and CC cord-028721-x6f26ahr 1930 35 interstitium interstitium NN cord-028721-x6f26ahr 1930 36 lacking lack VBG cord-028721-x6f26ahr 1930 37 mature mature JJ cord-028721-x6f26ahr 1930 38 Leydig Leydig NNP cord-028721-x6f26ahr 1930 39 cells cell NNS cord-028721-x6f26ahr 1930 40 . . . cord-028721-x6f26ahr 1931 1 [ [ -LRB- cord-028721-x6f26ahr 1931 2 888 888 CD cord-028721-x6f26ahr 1931 3 ] ] -RRB- cord-028721-x6f26ahr 1931 4 [ [ -LRB- cord-028721-x6f26ahr 1931 5 889 889 CD cord-028721-x6f26ahr 1931 6 ] ] -RRB- cord-028721-x6f26ahr 1932 1 [ [ -LRB- cord-028721-x6f26ahr 1932 2 890 890 CD cord-028721-x6f26ahr 1932 3 ] ] -RRB- cord-028721-x6f26ahr 1933 1 This this DT cord-028721-x6f26ahr 1933 2 syndrome syndrome NN cord-028721-x6f26ahr 1933 3 is be VBZ cord-028721-x6f26ahr 1933 4 caused cause VBN cord-028721-x6f26ahr 1933 5 by by IN cord-028721-x6f26ahr 1933 6 a a DT cord-028721-x6f26ahr 1933 7 defi defi NN cord-028721-x6f26ahr 1933 8 ciency ciency NN cord-028721-x6f26ahr 1933 9 of of IN cord-028721-x6f26ahr 1933 10 both both CC cord-028721-x6f26ahr 1933 11 FSH FSH NNP cord-028721-x6f26ahr 1933 12 and and CC cord-028721-x6f26ahr 1933 13 LH LH NNP cord-028721-x6f26ahr 1933 14 which which WDT cord-028721-x6f26ahr 1933 15 begins begin VBZ cord-028721-x6f26ahr 1933 16 in in IN cord-028721-x6f26ahr 1933 17 childhood childhood NN cord-028721-x6f26ahr 1933 18 and and CC cord-028721-x6f26ahr 1933 19 is be VBZ cord-028721-x6f26ahr 1933 20 responsible responsible JJ cord-028721-x6f26ahr 1933 21 for for IN cord-028721-x6f26ahr 1933 22 the the DT cord-028721-x6f26ahr 1933 23 lack lack NN cord-028721-x6f26ahr 1933 24 of of IN cord-028721-x6f26ahr 1933 25 maturation maturation NN cord-028721-x6f26ahr 1933 26 of of IN cord-028721-x6f26ahr 1933 27 the the DT cord-028721-x6f26ahr 1933 28 Sertoli Sertoli NNP cord-028721-x6f26ahr 1933 29 cells cell NNS cord-028721-x6f26ahr 1933 30 , , , cord-028721-x6f26ahr 1933 31 tubular tubular JJ cord-028721-x6f26ahr 1933 32 walls wall NNS cord-028721-x6f26ahr 1933 33 , , , cord-028721-x6f26ahr 1933 34 and and CC cord-028721-x6f26ahr 1933 35 interstitium interstitium NN cord-028721-x6f26ahr 1933 36 . . . cord-028721-x6f26ahr 1934 1 Subsequently subsequently RB cord-028721-x6f26ahr 1934 2 , , , cord-028721-x6f26ahr 1934 3 there there EX cord-028721-x6f26ahr 1934 4 is be VBZ cord-028721-x6f26ahr 1934 5 no no DT cord-028721-x6f26ahr 1934 6 renewal renewal NN cord-028721-x6f26ahr 1934 7 or or CC cord-028721-x6f26ahr 1934 8 differentiation differentiation NN cord-028721-x6f26ahr 1934 9 of of IN cord-028721-x6f26ahr 1934 10 germ germ NN cord-028721-x6f26ahr 1934 11 cells cell NNS cord-028721-x6f26ahr 1934 12 , , , cord-028721-x6f26ahr 1934 13 and and CC cord-028721-x6f26ahr 1934 14 these these DT cord-028721-x6f26ahr 1934 15 eventually eventually RB cord-028721-x6f26ahr 1934 16 disappear disappear VBP cord-028721-x6f26ahr 1934 17 . . . cord-028721-x6f26ahr 1935 1 When when WRB cord-028721-x6f26ahr 1935 2 these these DT cord-028721-x6f26ahr 1935 3 patients patient NNS cord-028721-x6f26ahr 1935 4 are be VBP cord-028721-x6f26ahr 1935 5 treated treat VBN cord-028721-x6f26ahr 1935 6 with with IN cord-028721-x6f26ahr 1935 7 hormones hormone NNS cord-028721-x6f26ahr 1935 8 , , , cord-028721-x6f26ahr 1935 9 the the DT cord-028721-x6f26ahr 1935 10 biopsy biopsy NN cord-028721-x6f26ahr 1935 11 may may MD cord-028721-x6f26ahr 1935 12 show show VB cord-028721-x6f26ahr 1935 13 some some DT cord-028721-x6f26ahr 1935 14 degree degree NN cord-028721-x6f26ahr 1935 15 of of IN cord-028721-x6f26ahr 1935 16 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1935 17 or or CC cord-028721-x6f26ahr 1935 18 thickening thickening NN cord-028721-x6f26ahr 1935 19 and and CC cord-028721-x6f26ahr 1935 20 hyalinization hyalinization NN cord-028721-x6f26ahr 1935 21 of of IN cord-028721-x6f26ahr 1935 22 the the DT cord-028721-x6f26ahr 1935 23 tubular tubular JJ cord-028721-x6f26ahr 1935 24 basement basement NN cord-028721-x6f26ahr 1935 25 membrane membrane NN cord-028721-x6f26ahr 1935 26 . . . cord-028721-x6f26ahr 1936 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1936 2 cell cell NN cord-028721-x6f26ahr 1936 3 - - HYPH cord-028721-x6f26ahr 1936 4 only only JJ cord-028721-x6f26ahr 1936 5 syndrome syndrome NN cord-028721-x6f26ahr 1936 6 with with IN cord-028721-x6f26ahr 1936 7 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1936 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 1936 9 cells cell NNS cord-028721-x6f26ahr 1936 10 Dysgenetic Dysgenetic NNP cord-028721-x6f26ahr 1936 11 Sertoli Sertoli NNP cord-028721-x6f26ahr 1936 12 cells cell NNS cord-028721-x6f26ahr 1936 13 begin begin VBP cord-028721-x6f26ahr 1936 14 pubertal pubertal JJ cord-028721-x6f26ahr 1936 15 differentiation differentiation NN cord-028721-x6f26ahr 1936 16 but but CC cord-028721-x6f26ahr 1936 17 variably variably RB cord-028721-x6f26ahr 1936 18 deviate deviate VBP cord-028721-x6f26ahr 1936 19 from from IN cord-028721-x6f26ahr 1936 20 normal normal JJ cord-028721-x6f26ahr 1936 21 maturation maturation NN cord-028721-x6f26ahr 1936 22 , , , cord-028721-x6f26ahr 1936 23 so so IN cord-028721-x6f26ahr 1936 24 that that IN cord-028721-x6f26ahr 1936 25 the the DT cord-028721-x6f26ahr 1936 26 morphology morphology NN cord-028721-x6f26ahr 1936 27 of of IN cord-028721-x6f26ahr 1936 28 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1936 29 Sertoli Sertoli NNP cord-028721-x6f26ahr 1936 30 cells cell NNS cord-028721-x6f26ahr 1936 31 differs differ VBZ cord-028721-x6f26ahr 1936 32 among among IN cord-028721-x6f26ahr 1936 33 tubules tubule NNS cord-028721-x6f26ahr 1936 34 and and CC cord-028721-x6f26ahr 1936 35 even even RB cord-028721-x6f26ahr 1936 36 among among IN cord-028721-x6f26ahr 1936 37 Sertoli Sertoli NNP cord-028721-x6f26ahr 1936 38 cells cell NNS cord-028721-x6f26ahr 1936 39 within within IN cord-028721-x6f26ahr 1936 40 the the DT cord-028721-x6f26ahr 1936 41 same same JJ cord-028721-x6f26ahr 1936 42 tubule tubule NN cord-028721-x6f26ahr 1936 43 . . . cord-028721-x6f26ahr 1937 1 Nuclei nuclei NN cord-028721-x6f26ahr 1937 2 usually usually RB cord-028721-x6f26ahr 1937 3 have have VBP cord-028721-x6f26ahr 1937 4 both both DT cord-028721-x6f26ahr 1937 5 mature mature JJ cord-028721-x6f26ahr 1937 6 features feature NNS cord-028721-x6f26ahr 1937 7 ( ( -LRB- cord-028721-x6f26ahr 1937 8 pale pale JJ cord-028721-x6f26ahr 1937 9 chromatin chromatin NN cord-028721-x6f26ahr 1937 10 and and CC cord-028721-x6f26ahr 1937 11 a a DT cord-028721-x6f26ahr 1937 12 centrally centrally RB cord-028721-x6f26ahr 1937 13 located locate VBN cord-028721-x6f26ahr 1937 14 , , , cord-028721-x6f26ahr 1937 15 tripartite tripartite JJ cord-028721-x6f26ahr 1937 16 nucleolus nucleolus NN cord-028721-x6f26ahr 1937 17 ) ) -RRB- cord-028721-x6f26ahr 1937 18 and and CC cord-028721-x6f26ahr 1937 19 features feature NNS cord-028721-x6f26ahr 1937 20 of of IN cord-028721-x6f26ahr 1937 21 immaturity immaturity NN cord-028721-x6f26ahr 1937 22 ( ( -LRB- cord-028721-x6f26ahr 1937 23 ovoid ovoid JJ cord-028721-x6f26ahr 1937 24 or or CC cord-028721-x6f26ahr 1937 25 round round JJ cord-028721-x6f26ahr 1937 26 shape shape NN cord-028721-x6f26ahr 1937 27 ; ; : cord-028721-x6f26ahr 1937 28 regular regular JJ cord-028721-x6f26ahr 1937 29 outline outline NN cord-028721-x6f26ahr 1937 30 ; ; : cord-028721-x6f26ahr 1937 31 and and CC cord-028721-x6f26ahr 1937 32 small small JJ cord-028721-x6f26ahr 1937 33 , , , cord-028721-x6f26ahr 1937 34 dense dense JJ cord-028721-x6f26ahr 1937 35 chromatin chromatin NN cord-028721-x6f26ahr 1937 36 granules granule NNS cord-028721-x6f26ahr 1937 37 ) ) -RRB- cord-028721-x6f26ahr 1938 1 ( ( -LRB- cord-028721-x6f26ahr 1938 2 Fig Fig NNP cord-028721-x6f26ahr 1938 3 . . . cord-028721-x6f26ahr 1938 4 12 12 CD cord-028721-x6f26ahr 1938 5 - - SYM cord-028721-x6f26ahr 1938 6 89 89 CD cord-028721-x6f26ahr 1938 7 ) ) -RRB- cord-028721-x6f26ahr 1938 8 . . . cord-028721-x6f26ahr 1939 1 891 891 CD cord-028721-x6f26ahr 1940 1 In in IN cord-028721-x6f26ahr 1940 2 addition addition NN cord-028721-x6f26ahr 1940 3 to to IN cord-028721-x6f26ahr 1940 4 vimentin vimentin NNS cord-028721-x6f26ahr 1940 5 , , , cord-028721-x6f26ahr 1940 6 Sertoli Sertoli NNP cord-028721-x6f26ahr 1940 7 cells cell VBZ cord-028721-x6f26ahr 1940 8 immunoexpress immunoexpress JJ cord-028721-x6f26ahr 1940 9 anti anti JJ cord-028721-x6f26ahr 1940 10 - - JJ cord-028721-x6f26ahr 1940 11 müllerian müllerian JJ cord-028721-x6f26ahr 1940 12 hormone hormone NN cord-028721-x6f26ahr 1940 13 ( ( -LRB- cord-028721-x6f26ahr 1940 14 AMH amh NN cord-028721-x6f26ahr 1940 15 ) ) -RRB- cord-028721-x6f26ahr 1941 1 892 892 CD cord-028721-x6f26ahr 1941 2 and and CC cord-028721-x6f26ahr 1941 3 cytokeratin cytokeratin NNP cord-028721-x6f26ahr 1941 4 18 18 CD cord-028721-x6f26ahr 1941 5 . . . cord-028721-x6f26ahr 1942 1 893 893 CD cord-028721-x6f26ahr 1942 2 Immunoreaction Immunoreaction NNP cord-028721-x6f26ahr 1942 3 to to IN cord-028721-x6f26ahr 1942 4 these these DT cord-028721-x6f26ahr 1942 5 two two CD cord-028721-x6f26ahr 1942 6 substances substance NNS cord-028721-x6f26ahr 1942 7 is be VBZ cord-028721-x6f26ahr 1942 8 assumed assume VBN cord-028721-x6f26ahr 1942 9 to to TO cord-028721-x6f26ahr 1942 10 be be VB cord-028721-x6f26ahr 1942 11 a a DT cord-028721-x6f26ahr 1942 12 sign sign NN cord-028721-x6f26ahr 1942 13 of of IN cord-028721-x6f26ahr 1942 14 immaturity immaturity NN cord-028721-x6f26ahr 1942 15 , , , cord-028721-x6f26ahr 1942 16 as as IN cord-028721-x6f26ahr 1942 17 under under IN cord-028721-x6f26ahr 1942 18 normal normal JJ cord-028721-x6f26ahr 1942 19 conditions condition NNS cord-028721-x6f26ahr 1942 20 it -PRON- PRP cord-028721-x6f26ahr 1942 21 is be VBZ cord-028721-x6f26ahr 1942 22 not not RB cord-028721-x6f26ahr 1942 23 detected detect VBN cord-028721-x6f26ahr 1942 24 after after IN cord-028721-x6f26ahr 1942 25 puberty puberty NN cord-028721-x6f26ahr 1942 26 . . . cord-028721-x6f26ahr 1943 1 Other other JJ cord-028721-x6f26ahr 1943 2 signs sign NNS cord-028721-x6f26ahr 1943 3 of of IN cord-028721-x6f26ahr 1943 4 immaturity immaturity NN cord-028721-x6f26ahr 1943 5 are be VBP cord-028721-x6f26ahr 1943 6 poor poor JJ cord-028721-x6f26ahr 1943 7 development development NN cord-028721-x6f26ahr 1943 8 of of IN cord-028721-x6f26ahr 1943 9 the the DT cord-028721-x6f26ahr 1943 10 hematotesticular hematotesticular NNP cord-028721-x6f26ahr 1943 11 barrier barrier NNP cord-028721-x6f26ahr 1943 12 894 894 CD cord-028721-x6f26ahr 1943 13 and and CC cord-028721-x6f26ahr 1943 14 the the DT cord-028721-x6f26ahr 1943 15 absence absence NN cord-028721-x6f26ahr 1943 16 of of IN cord-028721-x6f26ahr 1943 17 tubular tubular JJ cord-028721-x6f26ahr 1943 18 lumina lumina NNP cord-028721-x6f26ahr 1943 19 . . . cord-028721-x6f26ahr 1944 1 Tubular tubular JJ cord-028721-x6f26ahr 1944 2 lumina lumen NNS cord-028721-x6f26ahr 1944 3 are be VBP cord-028721-x6f26ahr 1944 4 very very RB cord-028721-x6f26ahr 1944 5 small small JJ cord-028721-x6f26ahr 1944 6 or or CC cord-028721-x6f26ahr 1944 7 absent absent JJ cord-028721-x6f26ahr 1944 8 in in IN cord-028721-x6f26ahr 1944 9 most most RBS cord-028721-x6f26ahr 1944 10 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1944 11 Sertoli sertoli JJ cord-028721-x6f26ahr 1944 12 cell cell NN cord-028721-x6f26ahr 1944 13 - - HYPH cord-028721-x6f26ahr 1944 14 containing contain VBG cord-028721-x6f26ahr 1944 15 tubules tubule NNS cord-028721-x6f26ahr 1944 16 , , , cord-028721-x6f26ahr 1944 17 because because IN cord-028721-x6f26ahr 1944 18 the the DT cord-028721-x6f26ahr 1944 19 ability ability NN cord-028721-x6f26ahr 1944 20 to to TO cord-028721-x6f26ahr 1944 21 produce produce VB cord-028721-x6f26ahr 1944 22 testicular testicular JJ cord-028721-x6f26ahr 1944 23 fl fl NNP cord-028721-x6f26ahr 1944 24 uid uid NN cord-028721-x6f26ahr 1944 25 is be VBZ cord-028721-x6f26ahr 1944 26 greatly greatly RB cord-028721-x6f26ahr 1944 27 reduced reduce VBN cord-028721-x6f26ahr 1944 28 . . . cord-028721-x6f26ahr 1945 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1945 2 cell cell NN cord-028721-x6f26ahr 1945 3 numbers number NNS cord-028721-x6f26ahr 1945 4 per per IN cord-028721-x6f26ahr 1945 5 cross cross JJ cord-028721-x6f26ahr 1945 6 - - JJ cord-028721-x6f26ahr 1945 7 sectioned sectioned JJ cord-028721-x6f26ahr 1945 8 tubule tubule NN cord-028721-x6f26ahr 1945 9 are be VBP cord-028721-x6f26ahr 1945 10 very very RB cord-028721-x6f26ahr 1945 11 high high JJ cord-028721-x6f26ahr 1945 12 , , , cord-028721-x6f26ahr 1945 13 and and CC cord-028721-x6f26ahr 1945 14 mean mean VB cord-028721-x6f26ahr 1945 15 tubular tubular JJ cord-028721-x6f26ahr 1945 16 diameter diameter NN cord-028721-x6f26ahr 1945 17 is be VBZ cord-028721-x6f26ahr 1945 18 lower low JJR cord-028721-x6f26ahr 1945 19 than than IN cord-028721-x6f26ahr 1945 20 120 120 CD cord-028721-x6f26ahr 1945 21 µm µm NN cord-028721-x6f26ahr 1945 22 . . . cord-028721-x6f26ahr 1946 1 The the DT cord-028721-x6f26ahr 1946 2 tubular tubular JJ cord-028721-x6f26ahr 1946 3 walls wall NNS cord-028721-x6f26ahr 1946 4 have have VBP cord-028721-x6f26ahr 1946 5 few few JJ cord-028721-x6f26ahr 1946 6 elastic elastic JJ cord-028721-x6f26ahr 1946 7 fi fi NN cord-028721-x6f26ahr 1946 8 bers ber NNS cord-028721-x6f26ahr 1946 9 , , , cord-028721-x6f26ahr 1946 10 534 534 CD cord-028721-x6f26ahr 1946 11 and and CC cord-028721-x6f26ahr 1946 12 most most JJS cord-028721-x6f26ahr 1946 13 tubules tubule NNS cord-028721-x6f26ahr 1946 14 show show VBP cord-028721-x6f26ahr 1946 15 a a DT cord-028721-x6f26ahr 1946 16 variable variable JJ cord-028721-x6f26ahr 1946 17 degree degree NN cord-028721-x6f26ahr 1946 18 of of IN cord-028721-x6f26ahr 1946 19 tunica tunica FW cord-028721-x6f26ahr 1946 20 propria propria NNP cord-028721-x6f26ahr 1946 21 hyalinization hyalinization NNP cord-028721-x6f26ahr 1946 22 . . . cord-028721-x6f26ahr 1947 1 Completely completely RB cord-028721-x6f26ahr 1947 2 hyalinized hyalinize VBN cord-028721-x6f26ahr 1947 3 tubules tubule NNS cord-028721-x6f26ahr 1947 4 are be VBP cord-028721-x6f26ahr 1947 5 frequent frequent JJ cord-028721-x6f26ahr 1947 6 . . . cord-028721-x6f26ahr 1948 1 The the DT cord-028721-x6f26ahr 1948 2 testicular testicular JJ cord-028721-x6f26ahr 1948 3 interstitium interstitium NN cord-028721-x6f26ahr 1948 4 contains contain VBZ cord-028721-x6f26ahr 1948 5 a a DT cord-028721-x6f26ahr 1948 6 variable variable JJ cord-028721-x6f26ahr 1948 7 number number NN cord-028721-x6f26ahr 1948 8 of of IN cord-028721-x6f26ahr 1948 9 Leydig Leydig NNP cord-028721-x6f26ahr 1948 10 cells cell NNS cord-028721-x6f26ahr 1948 11 ( ( -LRB- cord-028721-x6f26ahr 1948 12 normal normal JJ cord-028721-x6f26ahr 1948 13 , , , cord-028721-x6f26ahr 1948 14 decreased decrease VBD cord-028721-x6f26ahr 1948 15 , , , cord-028721-x6f26ahr 1948 16 or or CC cord-028721-x6f26ahr 1948 17 apparently apparently RB cord-028721-x6f26ahr 1948 18 increased increase VBN cord-028721-x6f26ahr 1948 19 ) ) -RRB- cord-028721-x6f26ahr 1948 20 , , , cord-028721-x6f26ahr 1948 21 many many JJ cord-028721-x6f26ahr 1948 22 of of IN cord-028721-x6f26ahr 1948 23 which which WDT cord-028721-x6f26ahr 1948 24 are be VBP cord-028721-x6f26ahr 1948 25 pleomorphic pleomorphic JJ cord-028721-x6f26ahr 1948 26 with with IN cord-028721-x6f26ahr 1948 27 abundant abundant JJ cord-028721-x6f26ahr 1948 28 paracrystalline paracrystalline NN cord-028721-x6f26ahr 1948 29 inclusions inclusion NNS cord-028721-x6f26ahr 1948 30 . . . cord-028721-x6f26ahr 1949 1 895 895 CD cord-028721-x6f26ahr 1949 2 , , , cord-028721-x6f26ahr 1949 3 896 896 CD cord-028721-x6f26ahr 1949 4 Most Most JJS cord-028721-x6f26ahr 1949 5 patients patient NNS cord-028721-x6f26ahr 1949 6 have have VBP cord-028721-x6f26ahr 1949 7 normal normal JJ cord-028721-x6f26ahr 1949 8 or or CC cord-028721-x6f26ahr 1949 9 slightly slightly RB cord-028721-x6f26ahr 1949 10 subnormal subnormal JJ cord-028721-x6f26ahr 1949 11 testosterone testosterone NN cord-028721-x6f26ahr 1949 12 level level NN cord-028721-x6f26ahr 1949 13 and and CC cord-028721-x6f26ahr 1949 14 elevated elevated JJ cord-028721-x6f26ahr 1949 15 levels level NNS cord-028721-x6f26ahr 1949 16 of of IN cord-028721-x6f26ahr 1949 17 FSH fsh NN cord-028721-x6f26ahr 1949 18 and and CC cord-028721-x6f26ahr 1949 19 LH LH NNP cord-028721-x6f26ahr 1949 20 . . . cord-028721-x6f26ahr 1950 1 This this DT cord-028721-x6f26ahr 1950 2 syndrome syndrome NN cord-028721-x6f26ahr 1950 3 can can MD cord-028721-x6f26ahr 1950 4 be be VB cord-028721-x6f26ahr 1950 5 observed observe VBN cord-028721-x6f26ahr 1950 6 in in IN cord-028721-x6f26ahr 1950 7 men man NNS cord-028721-x6f26ahr 1950 8 with with IN cord-028721-x6f26ahr 1950 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1950 10 testes testis NNS cord-028721-x6f26ahr 1950 11 , , , cord-028721-x6f26ahr 1950 12 at at IN cord-028721-x6f26ahr 1950 13 the the DT cord-028721-x6f26ahr 1950 14 periphery periphery NN cord-028721-x6f26ahr 1950 15 of of IN cord-028721-x6f26ahr 1950 16 germ germ NN cord-028721-x6f26ahr 1950 17 cell cell NN cord-028721-x6f26ahr 1950 18 tumors tumor NNS cord-028721-x6f26ahr 1950 19 , , , cord-028721-x6f26ahr 1950 20 in in IN cord-028721-x6f26ahr 1950 21 men man NNS cord-028721-x6f26ahr 1950 22 with with IN cord-028721-x6f26ahr 1950 23 idiopathic idiopathic JJ cord-028721-x6f26ahr 1950 24 infertility infertility NN cord-028721-x6f26ahr 1950 25 , , , cord-028721-x6f26ahr 1950 26 897 897 CD cord-028721-x6f26ahr 1950 27 and and CC cord-028721-x6f26ahr 1950 28 in in IN cord-028721-x6f26ahr 1950 29 men man NNS cord-028721-x6f26ahr 1950 30 with with IN cord-028721-x6f26ahr 1950 31 Y Y NNP cord-028721-x6f26ahr 1950 32 chromosome chromosome NN cord-028721-x6f26ahr 1950 33 anomalies anomaly NNS cord-028721-x6f26ahr 1950 34 . . . cord-028721-x6f26ahr 1951 1 898 898 CD cord-028721-x6f26ahr 1951 2 Sertoli sertoli JJ cord-028721-x6f26ahr 1951 3 cell cell NN cord-028721-x6f26ahr 1951 4 - - HYPH cord-028721-x6f26ahr 1951 5 only only JJ cord-028721-x6f26ahr 1951 6 syndrome syndrome NN cord-028721-x6f26ahr 1951 7 with with IN cord-028721-x6f26ahr 1951 8 mature mature JJ cord-028721-x6f26ahr 1951 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 1951 10 cells cell NNS cord-028721-x6f26ahr 1951 11 In in IN cord-028721-x6f26ahr 1951 12 this this DT cord-028721-x6f26ahr 1951 13 variant variant NN cord-028721-x6f26ahr 1951 14 , , , cord-028721-x6f26ahr 1951 15 most most JJS cord-028721-x6f26ahr 1951 16 Sertoli sertoli JJ cord-028721-x6f26ahr 1951 17 cells cell NNS cord-028721-x6f26ahr 1951 18 appear appear VBP cord-028721-x6f26ahr 1951 19 mature mature JJ cord-028721-x6f26ahr 1951 20 but but CC cord-028721-x6f26ahr 1951 21 are be VBP cord-028721-x6f26ahr 1951 22 present present JJ cord-028721-x6f26ahr 1951 23 in in IN cord-028721-x6f26ahr 1951 24 increased increase VBN cord-028721-x6f26ahr 1951 25 numbers number NNS cord-028721-x6f26ahr 1951 26 ( ( -LRB- cord-028721-x6f26ahr 1951 27 14 14 CD cord-028721-x6f26ahr 1951 28 ± ± CD cord-028721-x6f26ahr 1951 29 0.8 0.8 CD cord-028721-x6f26ahr 1951 30 per per IN cord-028721-x6f26ahr 1951 31 cross cross JJ cord-028721-x6f26ahr 1951 32 - - JJ cord-028721-x6f26ahr 1951 33 sectioned sectioned JJ cord-028721-x6f26ahr 1951 34 tubule tubule NN cord-028721-x6f26ahr 1951 35 ) ) -RRB- cord-028721-x6f26ahr 1951 36 . . . cord-028721-x6f26ahr 1952 1 The the DT cord-028721-x6f26ahr 1952 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 1952 3 tubules tubule NNS cord-028721-x6f26ahr 1952 4 have have VBP cord-028721-x6f26ahr 1952 5 small small JJ cord-028721-x6f26ahr 1952 6 diameters diameter NNS cord-028721-x6f26ahr 1952 7 , , , cord-028721-x6f26ahr 1952 8 but but CC cord-028721-x6f26ahr 1952 9 are be VBP cord-028721-x6f26ahr 1952 10 still still RB cord-028721-x6f26ahr 1952 11 larger large JJR cord-028721-x6f26ahr 1952 12 than than IN cord-028721-x6f26ahr 1952 13 in in IN cord-028721-x6f26ahr 1952 14 the the DT cord-028721-x6f26ahr 1952 15 two two CD cord-028721-x6f26ahr 1952 16 variants variant NNS cord-028721-x6f26ahr 1952 17 described describe VBN cord-028721-x6f26ahr 1952 18 above above RB cord-028721-x6f26ahr 1952 19 , , , cord-028721-x6f26ahr 1952 20 and and CC cord-028721-x6f26ahr 1952 21 central central NNP cord-028721-x6f26ahr 1952 22 lumina lumina NNP cord-028721-x6f26ahr 1952 23 are be VBP cord-028721-x6f26ahr 1952 24 visible visible JJ cord-028721-x6f26ahr 1952 25 . . . cord-028721-x6f26ahr 1953 1 The the DT cord-028721-x6f26ahr 1953 2 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1953 3 contains contain VBZ cord-028721-x6f26ahr 1953 4 abundant abundant JJ cord-028721-x6f26ahr 1953 5 vacuoles vacuole NNS cord-028721-x6f26ahr 1953 6 that that WDT cord-028721-x6f26ahr 1953 7 communicate communicate VBP cord-028721-x6f26ahr 1953 8 with with IN cord-028721-x6f26ahr 1953 9 the the DT cord-028721-x6f26ahr 1953 10 tubular tubular JJ cord-028721-x6f26ahr 1953 11 lumina lumina NNP cord-028721-x6f26ahr 1953 12 ( ( -LRB- cord-028721-x6f26ahr 1953 13 Fig Fig NNP cord-028721-x6f26ahr 1953 14 . . . cord-028721-x6f26ahr 1953 15 12 12 CD cord-028721-x6f26ahr 1953 16 - - SYM cord-028721-x6f26ahr 1953 17 90 90 CD cord-028721-x6f26ahr 1953 18 ) ) -RRB- cord-028721-x6f26ahr 1953 19 . . . cord-028721-x6f26ahr 1954 1 The the DT cord-028721-x6f26ahr 1954 2 lateral lateral JJ cord-028721-x6f26ahr 1954 3 cell cell NN cord-028721-x6f26ahr 1954 4 surfaces surface NNS cord-028721-x6f26ahr 1954 5 have have VBP cord-028721-x6f26ahr 1954 6 many many JJ cord-028721-x6f26ahr 1954 7 unfolding unfold VBG cord-028721-x6f26ahr 1954 8 and and CC cord-028721-x6f26ahr 1954 9 extensive extensive JJ cord-028721-x6f26ahr 1954 10 specialized specialized JJ cord-028721-x6f26ahr 1954 11 junctions junction NNS cord-028721-x6f26ahr 1954 12 with with IN cord-028721-x6f26ahr 1954 13 other other JJ cord-028721-x6f26ahr 1954 14 Sertoli Sertoli NNP cord-028721-x6f26ahr 1954 15 cells cell NNS cord-028721-x6f26ahr 1954 16 ( ( -LRB- cord-028721-x6f26ahr 1954 17 from from IN cord-028721-x6f26ahr 1954 18 the the DT cord-028721-x6f26ahr 1954 19 basement basement NN cord-028721-x6f26ahr 1954 20 membrane membrane NN cord-028721-x6f26ahr 1954 21 to to IN cord-028721-x6f26ahr 1954 22 the the DT cord-028721-x6f26ahr 1954 23 apical apical JJ cord-028721-x6f26ahr 1954 24 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 1954 25 portion portion NN cord-028721-x6f26ahr 1954 26 ) ) -RRB- cord-028721-x6f26ahr 1954 27 . . . cord-028721-x6f26ahr 1955 1 Lipid lipid NN cord-028721-x6f26ahr 1955 2 droplets droplet NNS cord-028721-x6f26ahr 1955 3 , , , cord-028721-x6f26ahr 1955 4 usually usually RB cord-028721-x6f26ahr 1955 5 derived derive VBN cord-028721-x6f26ahr 1955 6 from from IN cord-028721-x6f26ahr 1955 7 phagocytosis phagocytosis NN cord-028721-x6f26ahr 1955 8 of of IN cord-028721-x6f26ahr 1955 9 spermatid spermatid NNP cord-028721-x6f26ahr 1955 10 tubulobulbar tubulobulbar NN cord-028721-x6f26ahr 1955 11 complexes complex NNS cord-028721-x6f26ahr 1955 12 and and CC cord-028721-x6f26ahr 1955 13 dead dead JJ cord-028721-x6f26ahr 1955 14 germ germ NN cord-028721-x6f26ahr 1955 15 cells cell NNS cord-028721-x6f26ahr 1955 16 , , , cord-028721-x6f26ahr 1955 17 are be VBP cord-028721-x6f26ahr 1955 18 scant scant JJ cord-028721-x6f26ahr 1955 19 . . . cord-028721-x6f26ahr 1956 1 884 884 CD cord-028721-x6f26ahr 1957 1 Vimentin Vimentin NNP cord-028721-x6f26ahr 1957 2 fi fi NNP cord-028721-x6f26ahr 1957 3 laments lament NNS cord-028721-x6f26ahr 1957 4 are be VBP cord-028721-x6f26ahr 1957 5 abundant abundant JJ cord-028721-x6f26ahr 1957 6 in in IN cord-028721-x6f26ahr 1957 7 the the DT cord-028721-x6f26ahr 1957 8 basal basal NN cord-028721-x6f26ahr 1957 9 and and CC cord-028721-x6f26ahr 1957 10 perinuclear perinuclear NNP cord-028721-x6f26ahr 1957 11 cytoplasm cytoplasm NN cord-028721-x6f26ahr 1957 12 . . . cord-028721-x6f26ahr 1958 1 899 899 CD cord-028721-x6f26ahr 1959 1 The the DT cord-028721-x6f26ahr 1959 2 lamina lamina JJ cord-028721-x6f26ahr 1959 3 propria propria NN cord-028721-x6f26ahr 1959 4 is be VBZ cord-028721-x6f26ahr 1959 5 normal normal JJ cord-028721-x6f26ahr 1959 6 or or CC cord-028721-x6f26ahr 1959 7 slightly slightly RB cord-028721-x6f26ahr 1959 8 thickened thickened JJ cord-028721-x6f26ahr 1959 9 . . . cord-028721-x6f26ahr 1960 1 Leydig leydig NN cord-028721-x6f26ahr 1960 2 cells cell NNS cord-028721-x6f26ahr 1960 3 are be VBP cord-028721-x6f26ahr 1960 4 normal normal JJ cord-028721-x6f26ahr 1960 5 . . . cord-028721-x6f26ahr 1961 1 Serum serum NN cord-028721-x6f26ahr 1961 2 testosterone testosterone NN cord-028721-x6f26ahr 1961 3 level level NN cord-028721-x6f26ahr 1961 4 is be VBZ cord-028721-x6f26ahr 1961 5 normal normal JJ cord-028721-x6f26ahr 1961 6 or or CC cord-028721-x6f26ahr 1961 7 nearly nearly RB cord-028721-x6f26ahr 1961 8 normal normal JJ cord-028721-x6f26ahr 1961 9 , , , cord-028721-x6f26ahr 1961 10 and and CC cord-028721-x6f26ahr 1961 11 FSH fsh NN cord-028721-x6f26ahr 1961 12 and and CC cord-028721-x6f26ahr 1961 13 LH LH NNP cord-028721-x6f26ahr 1961 14 levels level NNS cord-028721-x6f26ahr 1961 15 are be VBP cord-028721-x6f26ahr 1961 16 elevated elevated JJ cord-028721-x6f26ahr 1961 17 . . . cord-028721-x6f26ahr 1962 1 [ [ -LRB- cord-028721-x6f26ahr 1962 2 900 900 CD cord-028721-x6f26ahr 1962 3 ] ] -RRB- cord-028721-x6f26ahr 1962 4 [ [ -LRB- cord-028721-x6f26ahr 1962 5 901 901 CD cord-028721-x6f26ahr 1962 6 ] ] -RRB- cord-028721-x6f26ahr 1962 7 [ [ -LRB- cord-028721-x6f26ahr 1962 8 902 902 CD cord-028721-x6f26ahr 1962 9 ] ] -RRB- cord-028721-x6f26ahr 1963 1 This this DT cord-028721-x6f26ahr 1963 2 syndrome syndrome NN cord-028721-x6f26ahr 1963 3 is be VBZ cord-028721-x6f26ahr 1963 4 probably probably RB cord-028721-x6f26ahr 1963 5 caused cause VBN cord-028721-x6f26ahr 1963 6 by by IN cord-028721-x6f26ahr 1963 7 failure failure NN cord-028721-x6f26ahr 1963 8 of of IN cord-028721-x6f26ahr 1963 9 migration migration NN cord-028721-x6f26ahr 1963 10 of of IN cord-028721-x6f26ahr 1963 11 primordial primordial JJ cord-028721-x6f26ahr 1963 12 germ germ NN cord-028721-x6f26ahr 1963 13 cells cell NNS cord-028721-x6f26ahr 1963 14 from from IN cord-028721-x6f26ahr 1963 15 the the DT cord-028721-x6f26ahr 1963 16 primitive primitive JJ cord-028721-x6f26ahr 1963 17 yolk yolk NN cord-028721-x6f26ahr 1963 18 sac sac NN cord-028721-x6f26ahr 1963 19 to to IN cord-028721-x6f26ahr 1963 20 the the DT cord-028721-x6f26ahr 1963 21 gonadal gonadal JJ cord-028721-x6f26ahr 1963 22 ridge ridge NN cord-028721-x6f26ahr 1963 23 . . . cord-028721-x6f26ahr 1964 1 903 903 CD cord-028721-x6f26ahr 1965 1 This this DT cord-028721-x6f26ahr 1965 2 failure failure NN cord-028721-x6f26ahr 1965 3 may may MD cord-028721-x6f26ahr 1965 4 be be VB cord-028721-x6f26ahr 1965 5 due due JJ cord-028721-x6f26ahr 1965 6 to to IN cord-028721-x6f26ahr 1965 7 a a DT cord-028721-x6f26ahr 1965 8 deletion deletion NN cord-028721-x6f26ahr 1965 9 in in IN cord-028721-x6f26ahr 1965 10 the the DT cord-028721-x6f26ahr 1965 11 AZFa AZFa NNS cord-028721-x6f26ahr 1965 12 region region NN cord-028721-x6f26ahr 1965 13 in in IN cord-028721-x6f26ahr 1965 14 Yq11 Yq11 NNP cord-028721-x6f26ahr 1965 15 904 904 CD cord-028721-x6f26ahr 1965 16 or or CC cord-028721-x6f26ahr 1965 17 a a DT cord-028721-x6f26ahr 1965 18 mutation mutation NN cord-028721-x6f26ahr 1965 19 in in IN cord-028721-x6f26ahr 1965 20 the the DT cord-028721-x6f26ahr 1965 21 genes gene NNS cord-028721-x6f26ahr 1965 22 that that WDT cord-028721-x6f26ahr 1965 23 encodes encode VBZ cord-028721-x6f26ahr 1965 24 c c NN cord-028721-x6f26ahr 1965 25 - - HYPH cord-028721-x6f26ahr 1965 26 KIT kit NN cord-028721-x6f26ahr 1965 27 or or CC cord-028721-x6f26ahr 1965 28 its -PRON- PRP$ cord-028721-x6f26ahr 1965 29 ligand ligand NN cord-028721-x6f26ahr 1965 30 ( ( -LRB- cord-028721-x6f26ahr 1965 31 stem stem NN cord-028721-x6f26ahr 1965 32 cell cell NN cord-028721-x6f26ahr 1965 33 factor factor NN cord-028721-x6f26ahr 1965 34 ) ) -RRB- cord-028721-x6f26ahr 1965 35 , , , cord-028721-x6f26ahr 1965 36 responsible responsible JJ cord-028721-x6f26ahr 1965 37 for for IN cord-028721-x6f26ahr 1965 38 migration migration NN cord-028721-x6f26ahr 1965 39 , , , cord-028721-x6f26ahr 1965 40 proliferation proliferation NN cord-028721-x6f26ahr 1965 41 , , , cord-028721-x6f26ahr 1965 42 and and CC cord-028721-x6f26ahr 1965 43 survival survival NN cord-028721-x6f26ahr 1965 44 of of IN cord-028721-x6f26ahr 1965 45 germ germ NN cord-028721-x6f26ahr 1965 46 cells cell NNS cord-028721-x6f26ahr 1965 47 . . . cord-028721-x6f26ahr 1966 1 Testes testis NNS cord-028721-x6f26ahr 1966 2 with with IN cord-028721-x6f26ahr 1966 3 this this DT cord-028721-x6f26ahr 1966 4 variant variant NN cord-028721-x6f26ahr 1966 5 of of IN cord-028721-x6f26ahr 1966 6 Sertoli Sertoli NNP cord-028721-x6f26ahr 1966 7 cell cell NN cord-028721-x6f26ahr 1966 8 - - HYPH cord-028721-x6f26ahr 1966 9 only only JJ cord-028721-x6f26ahr 1966 10 syndrome syndrome NN cord-028721-x6f26ahr 1966 11 have have VBP cord-028721-x6f26ahr 1966 12 numerous numerous JJ cord-028721-x6f26ahr 1966 13 changes change NNS cord-028721-x6f26ahr 1966 14 . . . cord-028721-x6f26ahr 1967 1 Sertoli sertoli JJ cord-028721-x6f26ahr 1967 2 cell cell NN cord-028721-x6f26ahr 1967 3 nuclei nucleus NNS cord-028721-x6f26ahr 1967 4 may may MD cord-028721-x6f26ahr 1967 5 have have VB cord-028721-x6f26ahr 1967 6 lobulated lobulate VBN cord-028721-x6f26ahr 1967 7 shapes shape NNS cord-028721-x6f26ahr 1967 8 with with IN cord-028721-x6f26ahr 1967 9 irregular irregular JJ cord-028721-x6f26ahr 1967 10 outlines outline NNS cord-028721-x6f26ahr 1967 11 , , , cord-028721-x6f26ahr 1967 12 coarse coarse JJ cord-028721-x6f26ahr 1967 13 chromatin chromatin NN cord-028721-x6f26ahr 1967 14 granules granule NNS cord-028721-x6f26ahr 1967 15 , , , cord-028721-x6f26ahr 1967 16 and and CC cord-028721-x6f26ahr 1967 17 inconspicuous inconspicuous JJ cord-028721-x6f26ahr 1967 18 nucleoli nucleolus NNS cord-028721-x6f26ahr 1967 19 . . . cord-028721-x6f26ahr 1968 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 1968 2 tubules tubule NNS cord-028721-x6f26ahr 1968 3 have have VBP cord-028721-x6f26ahr 1968 4 central central JJ cord-028721-x6f26ahr 1968 5 lumina lumina NNP cord-028721-x6f26ahr 1968 6 , , , cord-028721-x6f26ahr 1968 7 decreased decrease VBD cord-028721-x6f26ahr 1968 8 diameters diameter NNS cord-028721-x6f26ahr 1968 9 , , , cord-028721-x6f26ahr 1968 10 and and CC cord-028721-x6f26ahr 1968 11 variable variable JJ cord-028721-x6f26ahr 1968 12 thickening thickening NN cord-028721-x6f26ahr 1968 13 of of IN cord-028721-x6f26ahr 1968 14 the the DT cord-028721-x6f26ahr 1968 15 basement basement NN cord-028721-x6f26ahr 1968 16 membrane membrane NN cord-028721-x6f26ahr 1968 17 ( ( -LRB- cord-028721-x6f26ahr 1968 18 Fig Fig NNP cord-028721-x6f26ahr 1968 19 . . . cord-028721-x6f26ahr 1968 20 12 12 CD cord-028721-x6f26ahr 1968 21 - - SYM cord-028721-x6f26ahr 1968 22 91 91 CD cord-028721-x6f26ahr 1968 23 ) ) -RRB- cord-028721-x6f26ahr 1968 24 . . . cord-028721-x6f26ahr 1969 1 Elastic elastic JJ cord-028721-x6f26ahr 1969 2 fi fi NN cord-028721-x6f26ahr 1969 3 bers ber NNS cord-028721-x6f26ahr 1969 4 are be VBP cord-028721-x6f26ahr 1969 5 present present JJ cord-028721-x6f26ahr 1969 6 in in IN cord-028721-x6f26ahr 1969 7 normal normal JJ cord-028721-x6f26ahr 1969 8 or or CC cord-028721-x6f26ahr 1969 9 diminished diminished JJ cord-028721-x6f26ahr 1969 10 amounts amount NNS cord-028721-x6f26ahr 1969 11 . . . cord-028721-x6f26ahr 1970 1 Leydig leydig NN cord-028721-x6f26ahr 1970 2 cells cell NNS cord-028721-x6f26ahr 1970 3 are be VBP cord-028721-x6f26ahr 1970 4 variably variably RB cord-028721-x6f26ahr 1970 5 involuted involuted JJ cord-028721-x6f26ahr 1970 6 . . . cord-028721-x6f26ahr 1971 1 This this DT cord-028721-x6f26ahr 1971 2 syndrome syndrome NN cord-028721-x6f26ahr 1971 3 may may MD cord-028721-x6f26ahr 1971 4 be be VB cord-028721-x6f26ahr 1971 5 a a DT cord-028721-x6f26ahr 1971 6 primary primary JJ cord-028721-x6f26ahr 1971 7 disorder disorder NN cord-028721-x6f26ahr 1971 8 or or CC cord-028721-x6f26ahr 1971 9 secondary secondary JJ cord-028721-x6f26ahr 1971 10 to to IN cord-028721-x6f26ahr 1971 11 irradiation irradiation NN cord-028721-x6f26ahr 1971 12 or or CC cord-028721-x6f26ahr 1971 13 cytotoxic cytotoxic JJ cord-028721-x6f26ahr 1971 14 therapy therapy NN cord-028721-x6f26ahr 1971 15 , , , cord-028721-x6f26ahr 1971 16 such such JJ cord-028721-x6f26ahr 1971 17 as as IN cord-028721-x6f26ahr 1971 18 cancer cancer NN cord-028721-x6f26ahr 1971 19 chemotherapy chemotherapy NN cord-028721-x6f26ahr 1971 20 or or CC cord-028721-x6f26ahr 1971 21 treatment treatment NN cord-028721-x6f26ahr 1971 22 for for IN cord-028721-x6f26ahr 1971 23 nephrotic nephrotic JJ cord-028721-x6f26ahr 1971 24 syndrome syndrome NN cord-028721-x6f26ahr 1971 25 . . . cord-028721-x6f26ahr 1972 1 905 905 CD cord-028721-x6f26ahr 1973 1 It -PRON- PRP cord-028721-x6f26ahr 1973 2 is be VBZ cord-028721-x6f26ahr 1973 3 not not RB cord-028721-x6f26ahr 1973 4 usually usually RB cord-028721-x6f26ahr 1973 5 possible possible JJ cord-028721-x6f26ahr 1973 6 to to TO cord-028721-x6f26ahr 1973 7 determine determine VB cord-028721-x6f26ahr 1973 8 the the DT cord-028721-x6f26ahr 1973 9 etiology etiology NN cord-028721-x6f26ahr 1973 10 from from IN cord-028721-x6f26ahr 1973 11 the the DT cord-028721-x6f26ahr 1973 12 biopsy biopsy NN cord-028721-x6f26ahr 1973 13 fi fi NN cord-028721-x6f26ahr 1973 14 ndings nding NNS cord-028721-x6f26ahr 1973 15 alone alone JJ cord-028721-x6f26ahr 1973 16 . . . cord-028721-x6f26ahr 1974 1 Changes change NNS cord-028721-x6f26ahr 1974 2 in in IN cord-028721-x6f26ahr 1974 3 the the DT cord-028721-x6f26ahr 1974 4 tubular tubular JJ cord-028721-x6f26ahr 1974 5 walls wall NNS cord-028721-x6f26ahr 1974 6 are be VBP cord-028721-x6f26ahr 1974 7 more more RBR cord-028721-x6f26ahr 1974 8 pronounced pronounced JJ cord-028721-x6f26ahr 1974 9 in in IN cord-028721-x6f26ahr 1974 10 patients patient NNS cord-028721-x6f26ahr 1974 11 with with IN cord-028721-x6f26ahr 1974 12 a a DT cord-028721-x6f26ahr 1974 13 history history NN cord-028721-x6f26ahr 1974 14 of of IN cord-028721-x6f26ahr 1974 15 cyclophosphamide cyclophosphamide JJ cord-028721-x6f26ahr 1974 16 treatment treatment NN cord-028721-x6f26ahr 1974 17 , , , cord-028721-x6f26ahr 1974 18 combination combination NN cord-028721-x6f26ahr 1974 19 chemotherapy chemotherapy NN cord-028721-x6f26ahr 1974 20 , , , cord-028721-x6f26ahr 1974 21 or or CC cord-028721-x6f26ahr 1974 22 radiotherapy radiotherapy NN cord-028721-x6f26ahr 1974 23 . . . cord-028721-x6f26ahr 1975 1 The the DT cord-028721-x6f26ahr 1975 2 testicular testicular JJ cord-028721-x6f26ahr 1975 3 interstitium interstitium NN cord-028721-x6f26ahr 1975 4 may may MD cord-028721-x6f26ahr 1975 5 be be VB cord-028721-x6f26ahr 1975 6 fi fi NNP cord-028721-x6f26ahr 1975 7 brotic brotic VBN cord-028721-x6f26ahr 1975 8 in in IN cord-028721-x6f26ahr 1975 9 patients patient NNS cord-028721-x6f26ahr 1975 10 treated treat VBN cord-028721-x6f26ahr 1975 11 with with IN cord-028721-x6f26ahr 1975 12 cis cis NNP cord-028721-x6f26ahr 1975 13 - - HYPH cord-028721-x6f26ahr 1975 14 platinum platinum NN cord-028721-x6f26ahr 1975 15 or or CC cord-028721-x6f26ahr 1975 16 cyclophosphamide cyclophosphamide NN cord-028721-x6f26ahr 1975 17 . . . cord-028721-x6f26ahr 1976 1 906 906 CD cord-028721-x6f26ahr 1977 1 Some some DT cord-028721-x6f26ahr 1977 2 syndromes syndrome NNS cord-028721-x6f26ahr 1977 3 with with IN cord-028721-x6f26ahr 1977 4 involuting involute VBG cord-028721-x6f26ahr 1977 5 Sertoli sertoli JJ cord-028721-x6f26ahr 1977 6 cells cell NNS cord-028721-x6f26ahr 1977 7 , , , cord-028721-x6f26ahr 1977 8 mainly mainly RB cord-028721-x6f26ahr 1977 9 those those DT cord-028721-x6f26ahr 1977 10 associated associate VBN cord-028721-x6f26ahr 1977 11 with with IN cord-028721-x6f26ahr 1977 12 decreased decrease VBN cord-028721-x6f26ahr 1977 13 number number NN cord-028721-x6f26ahr 1977 14 of of IN cord-028721-x6f26ahr 1977 15 elastic elastic JJ cord-028721-x6f26ahr 1977 16 fi fi NN cord-028721-x6f26ahr 1977 17 bers ber NNS cord-028721-x6f26ahr 1977 18 , , , cord-028721-x6f26ahr 1977 19 probably probably RB cord-028721-x6f26ahr 1977 20 express express VB cord-028721-x6f26ahr 1977 21 a a DT cord-028721-x6f26ahr 1977 22 primary primary JJ cord-028721-x6f26ahr 1977 23 testicular testicular JJ cord-028721-x6f26ahr 1977 24 anomaly anomaly NN cord-028721-x6f26ahr 1977 25 with with IN cord-028721-x6f26ahr 1977 26 involuting involute VBG cord-028721-x6f26ahr 1977 27 and and CC cord-028721-x6f26ahr 1977 28 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1977 29 Sertoli Sertoli NNP cord-028721-x6f26ahr 1977 30 cells cell NNS cord-028721-x6f26ahr 1977 31 within within IN cord-028721-x6f26ahr 1977 32 the the DT cord-028721-x6f26ahr 1977 33 same same JJ cord-028721-x6f26ahr 1977 34 tubule tubule NN cord-028721-x6f26ahr 1977 35 . . . cord-028721-x6f26ahr 1978 1 The the DT cord-028721-x6f26ahr 1978 2 presence presence NN cord-028721-x6f26ahr 1978 3 of of IN cord-028721-x6f26ahr 1978 4 immature immature RB cord-028721-x6f26ahr 1978 5 - - HYPH cord-028721-x6f26ahr 1978 6 appearing appear VBG cord-028721-x6f26ahr 1978 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 1978 8 cells cell NNS cord-028721-x6f26ahr 1978 9 in in IN cord-028721-x6f26ahr 1978 10 The the DT cord-028721-x6f26ahr 1978 11 tubular tubular JJ cord-028721-x6f26ahr 1978 12 wall wall NN cord-028721-x6f26ahr 1978 13 is be VBZ cord-028721-x6f26ahr 1978 14 thickened thicken VBN cord-028721-x6f26ahr 1978 15 and and CC cord-028721-x6f26ahr 1978 16 contains contain VBZ cord-028721-x6f26ahr 1978 17 elastic elastic JJ cord-028721-x6f26ahr 1978 18 fi fi NN cord-028721-x6f26ahr 1978 19 bers ber NNS cord-028721-x6f26ahr 1978 20 , , , cord-028721-x6f26ahr 1978 21 increased increase VBD cord-028721-x6f26ahr 1978 22 amounts amount NNS cord-028721-x6f26ahr 1978 23 of of IN cord-028721-x6f26ahr 1978 24 collagen collagen NN cord-028721-x6f26ahr 1978 25 fi fi NNP cord-028721-x6f26ahr 1978 26 bers ber NNS cord-028721-x6f26ahr 1978 27 , , , cord-028721-x6f26ahr 1978 28 and and CC cord-028721-x6f26ahr 1978 29 elevated elevated JJ cord-028721-x6f26ahr 1978 30 numbers number NNS cord-028721-x6f26ahr 1978 31 of of IN cord-028721-x6f26ahr 1978 32 peritubular peritubular JJ cord-028721-x6f26ahr 1978 33 cells cell NNS cord-028721-x6f26ahr 1978 34 as as IN cord-028721-x6f26ahr 1978 35 a a DT cord-028721-x6f26ahr 1978 36 result result NN cord-028721-x6f26ahr 1978 37 of of IN cord-028721-x6f26ahr 1978 38 tubular tubular JJ cord-028721-x6f26ahr 1978 39 shortening shortening NN cord-028721-x6f26ahr 1978 40 . . . cord-028721-x6f26ahr 1979 1 Mean mean JJ cord-028721-x6f26ahr 1979 2 tubular tubular JJ cord-028721-x6f26ahr 1979 3 diameter diameter NN cord-028721-x6f26ahr 1979 4 is be VBZ cord-028721-x6f26ahr 1979 5 markedly markedly RB cord-028721-x6f26ahr 1979 6 decreased decrease VBN cord-028721-x6f26ahr 1979 7 to to IN cord-028721-x6f26ahr 1979 8 less less JJR cord-028721-x6f26ahr 1979 9 than than IN cord-028721-x6f26ahr 1979 10 90 90 CD cord-028721-x6f26ahr 1979 11 µm µm NN cord-028721-x6f26ahr 1979 12 . . . cord-028721-x6f26ahr 1980 1 The the DT cord-028721-x6f26ahr 1980 2 testicular testicular JJ cord-028721-x6f26ahr 1980 3 interstitium interstitium NN cord-028721-x6f26ahr 1980 4 contains contain VBZ cord-028721-x6f26ahr 1980 5 few few JJ cord-028721-x6f26ahr 1980 6 Leydig Leydig NNP cord-028721-x6f26ahr 1980 7 cells cell NNS cord-028721-x6f26ahr 1980 8 , , , cord-028721-x6f26ahr 1980 9 and and CC cord-028721-x6f26ahr 1980 10 these these DT cord-028721-x6f26ahr 1980 11 appear appear VBP cord-028721-x6f26ahr 1980 12 dedifferentiated dedifferentiate VBN cord-028721-x6f26ahr 1980 13 or or CC cord-028721-x6f26ahr 1980 14 contain contain VB cord-028721-x6f26ahr 1980 15 an an DT cord-028721-x6f26ahr 1980 16 increased increase VBN cord-028721-x6f26ahr 1980 17 amount amount NN cord-028721-x6f26ahr 1980 18 of of IN cord-028721-x6f26ahr 1980 19 lipofuscin lipofuscin NNS cord-028721-x6f26ahr 1980 20 . . . cord-028721-x6f26ahr 1981 1 This this DT cord-028721-x6f26ahr 1981 2 variant variant NN cord-028721-x6f26ahr 1981 3 has have VBZ cord-028721-x6f26ahr 1981 4 been be VBN cord-028721-x6f26ahr 1981 5 observed observe VBN cord-028721-x6f26ahr 1981 6 in in IN cord-028721-x6f26ahr 1981 7 surgical surgical JJ cord-028721-x6f26ahr 1981 8 specimens specimen NNS cord-028721-x6f26ahr 1981 9 from from IN cord-028721-x6f26ahr 1981 10 patients patient NNS cord-028721-x6f26ahr 1981 11 receiving receive VBG cord-028721-x6f26ahr 1981 12 androgen androgen NN cord-028721-x6f26ahr 1981 13 deprivation deprivation NN cord-028721-x6f26ahr 1981 14 therapy therapy NN cord-028721-x6f26ahr 1981 15 for for IN cord-028721-x6f26ahr 1981 16 prostatic prostatic JJ cord-028721-x6f26ahr 1981 17 cancer cancer NN cord-028721-x6f26ahr 1981 18 , , , cord-028721-x6f26ahr 1981 19 estrogen estrogen NN cord-028721-x6f26ahr 1981 20 treatment treatment NN cord-028721-x6f26ahr 1981 21 for for IN cord-028721-x6f26ahr 1981 22 transsexuality transsexuality NN cord-028721-x6f26ahr 1981 23 , , , cord-028721-x6f26ahr 1981 24 and and CC cord-028721-x6f26ahr 1981 25 cancer cancer NN cord-028721-x6f26ahr 1981 26 chemotherapy chemotherapy NN cord-028721-x6f26ahr 1981 27 with with IN cord-028721-x6f26ahr 1981 28 cis cis NNP cord-028721-x6f26ahr 1981 29 - - HYPH cord-028721-x6f26ahr 1981 30 platinum platinum NNP cord-028721-x6f26ahr 1981 31 . . . cord-028721-x6f26ahr 1982 1 There there EX cord-028721-x6f26ahr 1982 2 is be VBZ cord-028721-x6f26ahr 1982 3 a a DT cord-028721-x6f26ahr 1982 4 correlation correlation NN cord-028721-x6f26ahr 1982 5 between between IN cord-028721-x6f26ahr 1982 6 the the DT cord-028721-x6f26ahr 1982 7 degree degree NN cord-028721-x6f26ahr 1982 8 of of IN cord-028721-x6f26ahr 1982 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 1982 10 cell cell NN cord-028721-x6f26ahr 1982 11 dedifferentiation dedifferentiation NN cord-028721-x6f26ahr 1982 12 and and CC cord-028721-x6f26ahr 1982 13 the the DT cord-028721-x6f26ahr 1982 14 dose dose NN cord-028721-x6f26ahr 1982 15 and and CC cord-028721-x6f26ahr 1982 16 timing timing NN cord-028721-x6f26ahr 1982 17 of of IN cord-028721-x6f26ahr 1982 18 treatment treatment NN cord-028721-x6f26ahr 1982 19 with with IN cord-028721-x6f26ahr 1982 20 estrogens estrogen NNS cord-028721-x6f26ahr 1982 21 or or CC cord-028721-x6f26ahr 1982 22 anti anti NNS cord-028721-x6f26ahr 1982 23 - - NNS cord-028721-x6f26ahr 1982 24 androgens androgen NNS cord-028721-x6f26ahr 1982 25 . . . cord-028721-x6f26ahr 1983 1 Brief brief JJ cord-028721-x6f26ahr 1983 2 treatment treatment NN cord-028721-x6f26ahr 1983 3 induces induce VBZ cord-028721-x6f26ahr 1983 4 germ germ NN cord-028721-x6f26ahr 1983 5 cell cell NN cord-028721-x6f26ahr 1983 6 loss loss NN cord-028721-x6f26ahr 1983 7 and and CC cord-028721-x6f26ahr 1983 8 inconspicuous inconspicuous JJ cord-028721-x6f26ahr 1983 9 Sertoli sertoli JJ cord-028721-x6f26ahr 1983 10 cell cell NN cord-028721-x6f26ahr 1983 11 changes change NNS cord-028721-x6f26ahr 1983 12 ; ; : cord-028721-x6f26ahr 1983 13 long long JJ cord-028721-x6f26ahr 1983 14 - - HYPH cord-028721-x6f26ahr 1983 15 term term NN cord-028721-x6f26ahr 1983 16 treatment treatment NN cord-028721-x6f26ahr 1983 17 causes cause NNS cord-028721-x6f26ahr 1983 18 pronounced pronounce VBN cord-028721-x6f26ahr 1983 19 Sertoli sertoli JJ cord-028721-x6f26ahr 1983 20 cell cell NN cord-028721-x6f26ahr 1983 21 changes change NNS cord-028721-x6f26ahr 1983 22 , , , cord-028721-x6f26ahr 1983 23 including include VBG cord-028721-x6f26ahr 1983 24 initial initial JJ cord-028721-x6f26ahr 1983 25 nuclear nuclear JJ cord-028721-x6f26ahr 1983 26 rounding rounding NN cord-028721-x6f26ahr 1983 27 followed follow VBN cord-028721-x6f26ahr 1983 28 by by IN cord-028721-x6f26ahr 1983 29 nuclear nuclear JJ cord-028721-x6f26ahr 1983 30 elongation elongation NN cord-028721-x6f26ahr 1983 31 and and CC cord-028721-x6f26ahr 1983 32 the the DT cord-028721-x6f26ahr 1983 33 development development NN cord-028721-x6f26ahr 1983 34 of of IN cord-028721-x6f26ahr 1983 35 dark dark JJ cord-028721-x6f26ahr 1983 36 chromatin chromatin NN cord-028721-x6f26ahr 1983 37 masses masse NNS cord-028721-x6f26ahr 1983 38 . . . cord-028721-x6f26ahr 1984 1 907 907 CD cord-028721-x6f26ahr 1984 2 Eventually eventually RB cord-028721-x6f26ahr 1984 3 , , , cord-028721-x6f26ahr 1984 4 the the DT cord-028721-x6f26ahr 1984 5 nuclei nucleus NNS cord-028721-x6f26ahr 1984 6 come come VBP cord-028721-x6f26ahr 1984 7 to to TO cord-028721-x6f26ahr 1984 8 resemble resemble VB cord-028721-x6f26ahr 1984 9 those those DT cord-028721-x6f26ahr 1984 10 of of IN cord-028721-x6f26ahr 1984 11 infantile infantile JJ cord-028721-x6f26ahr 1984 12 Sertoli sertoli JJ cord-028721-x6f26ahr 1984 13 cells cell NNS cord-028721-x6f26ahr 1984 14 , , , cord-028721-x6f26ahr 1984 15 including include VBG cord-028721-x6f26ahr 1984 16 pseudostratifi pseudostratifi NNP cord-028721-x6f26ahr 1984 17 cation cation NN cord-028721-x6f26ahr 1984 18 . . . cord-028721-x6f26ahr 1985 1 At at IN cord-028721-x6f26ahr 1985 2 the the DT cord-028721-x6f26ahr 1985 3 same same JJ cord-028721-x6f26ahr 1985 4 time time NN cord-028721-x6f26ahr 1985 5 , , , cord-028721-x6f26ahr 1985 6 the the DT cord-028721-x6f26ahr 1985 7 tubules tubule NNS cord-028721-x6f26ahr 1985 8 become become VBP cord-028721-x6f26ahr 1985 9 hyalinized hyalinized JJ cord-028721-x6f26ahr 1985 10 and and CC cord-028721-x6f26ahr 1985 11 peritubular peritubular NNP cord-028721-x6f26ahr 1985 12 cells cell NNS cord-028721-x6f26ahr 1985 13 increase increase VBP cord-028721-x6f26ahr 1985 14 whereas whereas IN cord-028721-x6f26ahr 1985 15 Leydig leydig NN cord-028721-x6f26ahr 1985 16 cells cell NNS cord-028721-x6f26ahr 1985 17 disappear disappear VBP cord-028721-x6f26ahr 1985 18 . . . cord-028721-x6f26ahr 1986 1 908 908 CD cord-028721-x6f26ahr 1986 2 , , , cord-028721-x6f26ahr 1986 3 909 909 CD cord-028721-x6f26ahr 1986 4 Estrogens Estrogens NNP cord-028721-x6f26ahr 1986 5 act act NN cord-028721-x6f26ahr 1986 6 on on IN cord-028721-x6f26ahr 1986 7 the the DT cord-028721-x6f26ahr 1986 8 pituitary pituitary NN cord-028721-x6f26ahr 1986 9 by by IN cord-028721-x6f26ahr 1986 10 inhibiting inhibit VBG cord-028721-x6f26ahr 1986 11 LH LH NNP cord-028721-x6f26ahr 1986 12 secretion secretion NN cord-028721-x6f26ahr 1986 13 , , , cord-028721-x6f26ahr 1986 14 and and CC cord-028721-x6f26ahr 1986 15 on on IN cord-028721-x6f26ahr 1986 16 Leydig Leydig NNP cord-028721-x6f26ahr 1986 17 cells cell NNS cord-028721-x6f26ahr 1986 18 . . . cord-028721-x6f26ahr 1987 1 910 910 CD cord-028721-x6f26ahr 1988 1 The the DT cord-028721-x6f26ahr 1988 2 action action NN cord-028721-x6f26ahr 1988 3 of of IN cord-028721-x6f26ahr 1988 4 gonadotropin gonadotropin NN cord-028721-x6f26ahr 1988 5 - - HYPH cord-028721-x6f26ahr 1988 6 releasing release VBG cord-028721-x6f26ahr 1988 7 hormone hormone NN cord-028721-x6f26ahr 1988 8 agonist agonist NN cord-028721-x6f26ahr 1988 9 analogs analogs NN cord-028721-x6f26ahr 1988 10 is be VBZ cord-028721-x6f26ahr 1988 11 only only RB cord-028721-x6f26ahr 1988 12 on on IN cord-028721-x6f26ahr 1988 13 the the DT cord-028721-x6f26ahr 1988 14 pituitary pituitary NN cord-028721-x6f26ahr 1988 15 , , , cord-028721-x6f26ahr 1988 16 whereas whereas IN cord-028721-x6f26ahr 1988 17 cis cis NNP cord-028721-x6f26ahr 1988 18 - - HYPH cord-028721-x6f26ahr 1988 19 platinum platinum NN cord-028721-x6f26ahr 1988 20 acts act NNS cord-028721-x6f26ahr 1988 21 only only RB cord-028721-x6f26ahr 1988 22 on on IN cord-028721-x6f26ahr 1988 23 the the DT cord-028721-x6f26ahr 1988 24 testis testis NN cord-028721-x6f26ahr 1988 25 . . . cord-028721-x6f26ahr 1989 1 The the DT cord-028721-x6f26ahr 1989 2 most most RBS cord-028721-x6f26ahr 1989 3 common common JJ cord-028721-x6f26ahr 1989 4 causes cause NNS cord-028721-x6f26ahr 1989 5 of of IN cord-028721-x6f26ahr 1989 6 tubular tubular JJ cord-028721-x6f26ahr 1989 7 hyalinization hyalinization NN cord-028721-x6f26ahr 1989 8 include include VBP cord-028721-x6f26ahr 1989 9 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1989 10 hyalinization hyalinization NN cord-028721-x6f26ahr 1989 11 , , , cord-028721-x6f26ahr 1989 12 hormonal hormonal JJ cord-028721-x6f26ahr 1989 13 defi defi NNP cord-028721-x6f26ahr 1989 14 cit cit NNP cord-028721-x6f26ahr 1989 15 , , , cord-028721-x6f26ahr 1989 16 ischemia ischemia NN cord-028721-x6f26ahr 1989 17 , , , cord-028721-x6f26ahr 1989 18 obstruction obstruction NN cord-028721-x6f26ahr 1989 19 , , , cord-028721-x6f26ahr 1989 20 infl infl NN cord-028721-x6f26ahr 1989 21 ammation ammation NNP cord-028721-x6f26ahr 1989 22 , , , cord-028721-x6f26ahr 1989 23 and and CC cord-028721-x6f26ahr 1989 24 physical physical JJ cord-028721-x6f26ahr 1989 25 or or CC cord-028721-x6f26ahr 1989 26 chemical chemical JJ cord-028721-x6f26ahr 1989 27 agents agent NNS cord-028721-x6f26ahr 1989 28 . . . cord-028721-x6f26ahr 1990 1 The the DT cord-028721-x6f26ahr 1990 2 differential differential JJ cord-028721-x6f26ahr 1990 3 diagnosis diagnosis NN cord-028721-x6f26ahr 1990 4 is be VBZ cord-028721-x6f26ahr 1990 5 given give VBN cord-028721-x6f26ahr 1990 6 in in IN cord-028721-x6f26ahr 1990 7 Table Table NNP cord-028721-x6f26ahr 1990 8 12 12 CD cord-028721-x6f26ahr 1990 9 -8 -8 NNS cord-028721-x6f26ahr 1990 10 . . . cord-028721-x6f26ahr 1991 1 Dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1991 2 hyalinization hyalinization NN cord-028721-x6f26ahr 1992 1 Dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1992 2 hyalinization hyalinization NN cord-028721-x6f26ahr 1992 3 is be VBZ cord-028721-x6f26ahr 1992 4 a a DT cord-028721-x6f26ahr 1992 5 diffuse diffuse JJ cord-028721-x6f26ahr 1992 6 lesion lesion NN cord-028721-x6f26ahr 1992 7 in in IN cord-028721-x6f26ahr 1992 8 which which WDT cord-028721-x6f26ahr 1992 9 most most JJS cord-028721-x6f26ahr 1992 10 tubules tubule NNS cord-028721-x6f26ahr 1992 11 are be VBP cord-028721-x6f26ahr 1992 12 uniformly uniformly RB cord-028721-x6f26ahr 1992 13 hyalinized hyalinize VBN cord-028721-x6f26ahr 1992 14 ( ( -LRB- cord-028721-x6f26ahr 1992 15 Fig Fig NNP cord-028721-x6f26ahr 1992 16 . . . cord-028721-x6f26ahr 1992 17 _SP cord-028721-x6f26ahr 1993 1 12 12 CD cord-028721-x6f26ahr 1993 2 - - SYM cord-028721-x6f26ahr 1993 3 92 92 CD cord-028721-x6f26ahr 1993 4 ) ) -RRB- cord-028721-x6f26ahr 1993 5 . . . cord-028721-x6f26ahr 1994 1 Tubules Tubules NNP cord-028721-x6f26ahr 1994 2 lack lack VBP cord-028721-x6f26ahr 1994 3 seminiferous seminiferous JJ cord-028721-x6f26ahr 1994 4 tubular tubular JJ cord-028721-x6f26ahr 1994 5 cells cell NNS cord-028721-x6f26ahr 1994 6 and and CC cord-028721-x6f26ahr 1994 7 have have VBP cord-028721-x6f26ahr 1994 8 a a DT cord-028721-x6f26ahr 1994 9 reduced reduce VBN cord-028721-x6f26ahr 1994 10 number number NN cord-028721-x6f26ahr 1994 11 of of IN cord-028721-x6f26ahr 1994 12 peritubular peritubular JJ cord-028721-x6f26ahr 1994 13 cells cell NNS cord-028721-x6f26ahr 1994 14 . . . cord-028721-x6f26ahr 1995 1 The the DT cord-028721-x6f26ahr 1995 2 few few JJ cord-028721-x6f26ahr 1995 3 preserved preserve VBN cord-028721-x6f26ahr 1995 4 tubules tubule NNS cord-028721-x6f26ahr 1995 5 usually usually RB cord-028721-x6f26ahr 1995 6 contain contain VBP cord-028721-x6f26ahr 1995 7 only only RB cord-028721-x6f26ahr 1995 8 Sertoli sertoli JJ cord-028721-x6f26ahr 1995 9 cells cell NNS cord-028721-x6f26ahr 1995 10 , , , cord-028721-x6f26ahr 1995 11 although although IN cord-028721-x6f26ahr 1995 12 rarely rarely RB cord-028721-x6f26ahr 1995 13 a a DT cord-028721-x6f26ahr 1995 14 few few JJ cord-028721-x6f26ahr 1995 15 with with IN cord-028721-x6f26ahr 1995 16 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 1995 17 are be VBP cord-028721-x6f26ahr 1995 18 present present JJ cord-028721-x6f26ahr 1995 19 . . . cord-028721-x6f26ahr 1996 1 Dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1996 2 hyalinization hyalinization NN cord-028721-x6f26ahr 1996 3 is be VBZ cord-028721-x6f26ahr 1996 4 seen see VBN cord-028721-x6f26ahr 1996 5 in in IN cord-028721-x6f26ahr 1996 6 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 1996 7 's 's POS cord-028721-x6f26ahr 1996 8 syndrome syndrome NN cord-028721-x6f26ahr 1996 9 , , , cord-028721-x6f26ahr 1996 10 testes testis NNS cord-028721-x6f26ahr 1996 11 that that WDT cord-028721-x6f26ahr 1996 12 remain remain VBP cord-028721-x6f26ahr 1996 13 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 1996 14 through through IN cord-028721-x6f26ahr 1996 15 puberty puberty NN cord-028721-x6f26ahr 1996 16 , , , cord-028721-x6f26ahr 1996 17 and and CC cord-028721-x6f26ahr 1996 18 some some DT cord-028721-x6f26ahr 1996 19 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 1996 20 hypogonadisms hypogonadisms NNP cord-028721-x6f26ahr 1996 21 associated associate VBN cord-028721-x6f26ahr 1996 22 with with IN cord-028721-x6f26ahr 1996 23 myopathy myopathy NN cord-028721-x6f26ahr 1996 24 . . . cord-028721-x6f26ahr 1997 1 Focal focal JJ cord-028721-x6f26ahr 1997 2 lesions lesion NNS cord-028721-x6f26ahr 1997 3 are be VBP cord-028721-x6f26ahr 1997 4 seen see VBN cord-028721-x6f26ahr 1997 5 in in IN cord-028721-x6f26ahr 1997 6 mixed mixed JJ cord-028721-x6f26ahr 1997 7 atrophy atrophy NN cord-028721-x6f26ahr 1997 8 of of IN cord-028721-x6f26ahr 1997 9 the the DT cord-028721-x6f26ahr 1997 10 testis testis NN cord-028721-x6f26ahr 1997 11 . . . cord-028721-x6f26ahr 1998 1 Tubular tubular JJ cord-028721-x6f26ahr 1998 2 hyalinization hyalinization NN cord-028721-x6f26ahr 1998 3 is be VBZ cord-028721-x6f26ahr 1998 4 pronounced pronounce VBN cord-028721-x6f26ahr 1998 5 in in IN cord-028721-x6f26ahr 1998 6 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 1998 7 's 's POS cord-028721-x6f26ahr 1998 8 syndrome syndrome NN cord-028721-x6f26ahr 1998 9 , , , cord-028721-x6f26ahr 1998 10 and and CC cord-028721-x6f26ahr 1998 11 from from IN cord-028721-x6f26ahr 1998 12 infancy infancy NN cord-028721-x6f26ahr 1998 13 the the DT cord-028721-x6f26ahr 1998 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 1998 15 tubules tubule NNS cord-028721-x6f26ahr 1998 16 are be VBP cord-028721-x6f26ahr 1998 17 small small JJ cord-028721-x6f26ahr 1998 18 , , , cord-028721-x6f26ahr 1998 19 containing contain VBG cord-028721-x6f26ahr 1998 20 reduced reduce VBN cord-028721-x6f26ahr 1998 21 numbers number NNS cord-028721-x6f26ahr 1998 22 of of IN cord-028721-x6f26ahr 1998 23 Sertoli sertoli JJ cord-028721-x6f26ahr 1998 24 cells cell NNS cord-028721-x6f26ahr 1998 25 and and CC cord-028721-x6f26ahr 1998 26 few few JJ cord-028721-x6f26ahr 1998 27 or or CC cord-028721-x6f26ahr 1998 28 no no DT cord-028721-x6f26ahr 1998 29 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 1998 30 . . . cord-028721-x6f26ahr 1999 1 At at IN cord-028721-x6f26ahr 1999 2 puberty puberty NN cord-028721-x6f26ahr 1999 3 , , , cord-028721-x6f26ahr 1999 4 the the DT cord-028721-x6f26ahr 1999 5 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 1999 6 Sertoli Sertoli NNP cord-028721-x6f26ahr 1999 7 cells cell NNS cord-028721-x6f26ahr 1999 8 fail fail VBP cord-028721-x6f26ahr 1999 9 to to IN cord-028721-x6f26ahr 1999 10 Infertility infertility NN cord-028721-x6f26ahr 1999 11 mature mature JJ cord-028721-x6f26ahr 1999 12 and and CC cord-028721-x6f26ahr 1999 13 soon soon RB cord-028721-x6f26ahr 1999 14 disappear disappear VBP cord-028721-x6f26ahr 1999 15 . . . cord-028721-x6f26ahr 2000 1 The the DT cord-028721-x6f26ahr 2000 2 tubules tubule NNS cord-028721-x6f26ahr 2000 3 collapse collapse VBP cord-028721-x6f26ahr 2000 4 , , , cord-028721-x6f26ahr 2000 5 giving give VBG cord-028721-x6f26ahr 2000 6 the the DT cord-028721-x6f26ahr 2000 7 appearance appearance NN cord-028721-x6f26ahr 2000 8 of of IN cord-028721-x6f26ahr 2000 9 phantom phantom JJ cord-028721-x6f26ahr 2000 10 tubules tubule NNS cord-028721-x6f26ahr 2000 11 . . . cord-028721-x6f26ahr 2001 1 911 911 CD cord-028721-x6f26ahr 2001 2 Peritubular Peritubular NNP cord-028721-x6f26ahr 2001 3 cells cell NNS cord-028721-x6f26ahr 2001 4 fail fail VBP cord-028721-x6f26ahr 2001 5 to to TO cord-028721-x6f26ahr 2001 6 differentiate differentiate VB cord-028721-x6f26ahr 2001 7 and and CC cord-028721-x6f26ahr 2001 8 their -PRON- PRP$ cord-028721-x6f26ahr 2001 9 number number NN cord-028721-x6f26ahr 2001 10 is be VBZ cord-028721-x6f26ahr 2001 11 low low JJ cord-028721-x6f26ahr 2001 12 . . . cord-028721-x6f26ahr 2002 1 912 912 CD cord-028721-x6f26ahr 2003 1 They -PRON- PRP cord-028721-x6f26ahr 2003 2 form form VBP cord-028721-x6f26ahr 2003 3 a a DT cord-028721-x6f26ahr 2003 4 discontinuous discontinuous JJ cord-028721-x6f26ahr 2003 5 ring ring NN cord-028721-x6f26ahr 2003 6 around around IN cord-028721-x6f26ahr 2003 7 the the DT cord-028721-x6f26ahr 2003 8 hyalinized hyalinize VBN cord-028721-x6f26ahr 2003 9 tubules tubule NNS cord-028721-x6f26ahr 2003 10 and and CC cord-028721-x6f26ahr 2003 11 are be VBP cord-028721-x6f26ahr 2003 12 incapable incapable JJ cord-028721-x6f26ahr 2003 13 of of IN cord-028721-x6f26ahr 2003 14 synthesizing synthesize VBG cord-028721-x6f26ahr 2003 15 elastic elastic JJ cord-028721-x6f26ahr 2003 16 fi fi NN cord-028721-x6f26ahr 2003 17 bers ber NNS cord-028721-x6f26ahr 2003 18 and and CC cord-028721-x6f26ahr 2003 19 other other JJ cord-028721-x6f26ahr 2003 20 components component NNS cord-028721-x6f26ahr 2003 21 of of IN cord-028721-x6f26ahr 2003 22 the the DT cord-028721-x6f26ahr 2003 23 lamina lamina JJ cord-028721-x6f26ahr 2003 24 propria propria NN cord-028721-x6f26ahr 2003 25 . . . cord-028721-x6f26ahr 2004 1 Dysgenesis Dysgenesis NNP cord-028721-x6f26ahr 2004 2 also also RB cord-028721-x6f26ahr 2004 3 involves involve VBZ cord-028721-x6f26ahr 2004 4 the the DT cord-028721-x6f26ahr 2004 5 interstitium interstitium NN cord-028721-x6f26ahr 2004 6 : : : cord-028721-x6f26ahr 2004 7 Leydig leydig NN cord-028721-x6f26ahr 2004 8 cells cell NNS cord-028721-x6f26ahr 2004 9 exhibit exhibit VBP cord-028721-x6f26ahr 2004 10 a a DT cord-028721-x6f26ahr 2004 11 characteristic characteristic JJ cord-028721-x6f26ahr 2004 12 adenomatous adenomatous JJ cord-028721-x6f26ahr 2004 13 pattern pattern NN cord-028721-x6f26ahr 2004 14 , , , cord-028721-x6f26ahr 2004 15 although although IN cord-028721-x6f26ahr 2004 16 their -PRON- PRP$ cord-028721-x6f26ahr 2004 17 total total JJ cord-028721-x6f26ahr 2004 18 number number NN cord-028721-x6f26ahr 2004 19 is be VBZ cord-028721-x6f26ahr 2004 20 decreased decrease VBN cord-028721-x6f26ahr 2004 21 . . . cord-028721-x6f26ahr 2005 1 The the DT cord-028721-x6f26ahr 2005 2 morphology morphology NN cord-028721-x6f26ahr 2005 3 of of IN cord-028721-x6f26ahr 2005 4 the the DT cord-028721-x6f26ahr 2005 5 Leydig Leydig NNP cord-028721-x6f26ahr 2005 6 cell cell NN cord-028721-x6f26ahr 2005 7 is be VBZ cord-028721-x6f26ahr 2005 8 not not RB cord-028721-x6f26ahr 2005 9 uniform uniform JJ cord-028721-x6f26ahr 2005 10 , , , cord-028721-x6f26ahr 2005 11 and and CC cord-028721-x6f26ahr 2005 12 there there EX cord-028721-x6f26ahr 2005 13 are be VBP cord-028721-x6f26ahr 2005 14 shrunken shrunken JJ cord-028721-x6f26ahr 2005 15 , , , cord-028721-x6f26ahr 2005 16 normal normal JJ cord-028721-x6f26ahr 2005 17 , , , cord-028721-x6f26ahr 2005 18 and and CC cord-028721-x6f26ahr 2005 19 large large JJ cord-028721-x6f26ahr 2005 20 forms form NNS cord-028721-x6f26ahr 2005 21 . . . cord-028721-x6f26ahr 2006 1 Most Most JJS cord-028721-x6f26ahr 2006 2 contain contain VBP cord-028721-x6f26ahr 2006 3 reduced reduce VBN cord-028721-x6f26ahr 2006 4 amounts amount NNS cord-028721-x6f26ahr 2006 5 of of IN cord-028721-x6f26ahr 2006 6 lipofuscin lipofuscin NNS cord-028721-x6f26ahr 2006 7 granules granule NNS cord-028721-x6f26ahr 2006 8 and and CC cord-028721-x6f26ahr 2006 9 lipid lipid NN cord-028721-x6f26ahr 2006 10 droplets droplet NNS cord-028721-x6f26ahr 2006 11 . . . cord-028721-x6f26ahr 2007 1 Reinke Reinke NNP cord-028721-x6f26ahr 2007 2 's 's POS cord-028721-x6f26ahr 2007 3 crystalloids crystalloid NNS cord-028721-x6f26ahr 2007 4 are be VBP cord-028721-x6f26ahr 2007 5 uncommon uncommon JJ cord-028721-x6f26ahr 2007 6 , , , cord-028721-x6f26ahr 2007 7 and and CC cord-028721-x6f26ahr 2007 8 paracrystalline paracrystalline NN cord-028721-x6f26ahr 2007 9 inclusions inclusion NNS cord-028721-x6f26ahr 2007 10 are be VBP cord-028721-x6f26ahr 2007 11 abundant abundant JJ cord-028721-x6f26ahr 2007 12 . . . cord-028721-x6f26ahr 2008 1 896 896 CD cord-028721-x6f26ahr 2009 1 In in IN cord-028721-x6f26ahr 2009 2 spite spite NN cord-028721-x6f26ahr 2009 3 of of IN cord-028721-x6f26ahr 2009 4 the the DT cord-028721-x6f26ahr 2009 5 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 2009 6 adenomatous adenomatous JJ cord-028721-x6f26ahr 2009 7 appearance appearance NN cord-028721-x6f26ahr 2009 8 of of IN cord-028721-x6f26ahr 2009 9 the the DT cord-028721-x6f26ahr 2009 10 Leydig Leydig NNP cord-028721-x6f26ahr 2009 11 cells cell NNS cord-028721-x6f26ahr 2009 12 , , , cord-028721-x6f26ahr 2009 13 testosterone testosterone NN cord-028721-x6f26ahr 2009 14 secretion secretion NN cord-028721-x6f26ahr 2009 15 is be VBZ cord-028721-x6f26ahr 2009 16 markedly markedly RB cord-028721-x6f26ahr 2009 17 decreased decrease VBN cord-028721-x6f26ahr 2009 18 , , , cord-028721-x6f26ahr 2009 19 and and CC cord-028721-x6f26ahr 2009 20 the the DT cord-028721-x6f26ahr 2009 21 resulting result VBG cord-028721-x6f26ahr 2009 22 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2009 23 is be VBZ cord-028721-x6f26ahr 2009 24 the the DT cord-028721-x6f26ahr 2009 25 most most RBS cord-028721-x6f26ahr 2009 26 important important JJ cord-028721-x6f26ahr 2009 27 clinical clinical JJ cord-028721-x6f26ahr 2009 28 feature feature NN cord-028721-x6f26ahr 2009 29 of of IN cord-028721-x6f26ahr 2009 30 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2009 31 's 's POS cord-028721-x6f26ahr 2009 32 syndrome syndrome NN cord-028721-x6f26ahr 2009 33 . . . cord-028721-x6f26ahr 2010 1 Tubular tubular JJ cord-028721-x6f26ahr 2010 2 hyalinization hyalinization NN cord-028721-x6f26ahr 2010 3 in in IN cord-028721-x6f26ahr 2010 4 the the DT cord-028721-x6f26ahr 2010 5 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 2010 6 testis testis NN cord-028721-x6f26ahr 2010 7 is be VBZ cord-028721-x6f26ahr 2010 8 also also RB cord-028721-x6f26ahr 2010 9 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2010 10 . . . cord-028721-x6f26ahr 2011 1 However however RB cord-028721-x6f26ahr 2011 2 , , , cord-028721-x6f26ahr 2011 3 in in IN cord-028721-x6f26ahr 2011 4 contrast contrast NN cord-028721-x6f26ahr 2011 5 to to IN cord-028721-x6f26ahr 2011 6 the the DT cord-028721-x6f26ahr 2011 7 atrophic atrophic JJ cord-028721-x6f26ahr 2011 8 collapse collapse NN cord-028721-x6f26ahr 2011 9 seen see VBN cord-028721-x6f26ahr 2011 10 in in IN cord-028721-x6f26ahr 2011 11 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2011 12 's 's POS cord-028721-x6f26ahr 2011 13 syndrome syndrome NN cord-028721-x6f26ahr 2011 14 , , , cord-028721-x6f26ahr 2011 15 cross cross NN cord-028721-x6f26ahr 2011 16 - - NNS cord-028721-x6f26ahr 2011 17 sections section NNS cord-028721-x6f26ahr 2011 18 of of IN cord-028721-x6f26ahr 2011 19 the the DT cord-028721-x6f26ahr 2011 20 hyalinized hyalinize VBN cord-028721-x6f26ahr 2011 21 tubules tubule NNS cord-028721-x6f26ahr 2011 22 in in IN cord-028721-x6f26ahr 2011 23 cryptorchidism cryptorchidism NNS cord-028721-x6f26ahr 2011 24 are be VBP cord-028721-x6f26ahr 2011 25 targetoid targetoid JJ cord-028721-x6f26ahr 2011 26 . . . cord-028721-x6f26ahr 2012 1 This this DT cord-028721-x6f26ahr 2012 2 results result VBZ cord-028721-x6f26ahr 2012 3 from from IN cord-028721-x6f26ahr 2012 4 the the DT cord-028721-x6f26ahr 2012 5 arrangement arrangement NN cord-028721-x6f26ahr 2012 6 of of IN cord-028721-x6f26ahr 2012 7 the the DT cord-028721-x6f26ahr 2012 8 peritubular peritubular NNP cord-028721-x6f26ahr 2012 9 cells cell NNS cord-028721-x6f26ahr 2012 10 into into IN cord-028721-x6f26ahr 2012 11 two two CD cord-028721-x6f26ahr 2012 12 layers layer NNS cord-028721-x6f26ahr 2012 13 , , , cord-028721-x6f26ahr 2012 14 suggesting suggest VBG cord-028721-x6f26ahr 2012 15 an an DT cord-028721-x6f26ahr 2012 16 atrophic atrophic JJ cord-028721-x6f26ahr 2012 17 process process NN cord-028721-x6f26ahr 2012 18 that that WDT cord-028721-x6f26ahr 2012 19 has have VBZ cord-028721-x6f26ahr 2012 20 evolved evolve VBN cord-028721-x6f26ahr 2012 21 over over IN cord-028721-x6f26ahr 2012 22 a a DT cord-028721-x6f26ahr 2012 23 longer long JJR cord-028721-x6f26ahr 2012 24 period period NN cord-028721-x6f26ahr 2012 25 than than IN cord-028721-x6f26ahr 2012 26 in in IN cord-028721-x6f26ahr 2012 27 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2012 28 's 's POS cord-028721-x6f26ahr 2012 29 syndrome syndrome NN cord-028721-x6f26ahr 2012 30 , , , cord-028721-x6f26ahr 2012 31 or or CC cord-028721-x6f26ahr 2012 32 a a DT cord-028721-x6f26ahr 2012 33 lower low JJR cord-028721-x6f26ahr 2012 34 degree degree NN cord-028721-x6f26ahr 2012 35 of of IN cord-028721-x6f26ahr 2012 36 dysgenesis dysgenesis NN cord-028721-x6f26ahr 2012 37 . . . cord-028721-x6f26ahr 2013 1 913 913 CD cord-028721-x6f26ahr 2014 1 Elastic elastic JJ cord-028721-x6f26ahr 2014 2 fi fi NN cord-028721-x6f26ahr 2014 3 bers ber NNS cord-028721-x6f26ahr 2014 4 are be VBP cord-028721-x6f26ahr 2014 5 diminished diminish VBN cord-028721-x6f26ahr 2014 6 . . . cord-028721-x6f26ahr 2015 1 534 534 CD cord-028721-x6f26ahr 2016 1 In in IN cord-028721-x6f26ahr 2016 2 the the DT cord-028721-x6f26ahr 2016 3 interstitium interstitium JJ cord-028721-x6f26ahr 2016 4 Leydig Leydig NNP cord-028721-x6f26ahr 2016 5 cells cell NNS cord-028721-x6f26ahr 2016 6 appear appear VBP cord-028721-x6f26ahr 2016 7 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 2016 8 , , , cord-028721-x6f26ahr 2016 9 forming form VBG cord-028721-x6f26ahr 2016 10 large large JJ cord-028721-x6f26ahr 2016 11 aggregates aggregate NNS cord-028721-x6f26ahr 2016 12 , , , cord-028721-x6f26ahr 2016 13 although although IN cord-028721-x6f26ahr 2016 14 their -PRON- PRP$ cord-028721-x6f26ahr 2016 15 absolute absolute JJ cord-028721-x6f26ahr 2016 16 numbers number NNS cord-028721-x6f26ahr 2016 17 are be VBP cord-028721-x6f26ahr 2016 18 decreased decrease VBN cord-028721-x6f26ahr 2016 19 . . . cord-028721-x6f26ahr 2017 1 Leydig leydig NN cord-028721-x6f26ahr 2017 2 cell cell NN cord-028721-x6f26ahr 2017 3 pleomorphism pleomorphism NN cord-028721-x6f26ahr 2017 4 is be VBZ cord-028721-x6f26ahr 2017 5 less less RBR cord-028721-x6f26ahr 2017 6 intense intense JJ cord-028721-x6f26ahr 2017 7 than than IN cord-028721-x6f26ahr 2017 8 in in IN cord-028721-x6f26ahr 2017 9 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2017 10 's 's POS cord-028721-x6f26ahr 2017 11 syndrome syndrome NN cord-028721-x6f26ahr 2017 12 . . . cord-028721-x6f26ahr 2018 1 Many many JJ cord-028721-x6f26ahr 2018 2 Leydig leydig NN cord-028721-x6f26ahr 2018 3 cells cell NNS cord-028721-x6f26ahr 2018 4 have have VBP cord-028721-x6f26ahr 2018 5 abundant abundant JJ cord-028721-x6f26ahr 2018 6 vacuolated vacuolate VBN cord-028721-x6f26ahr 2018 7 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2018 8 . . . cord-028721-x6f26ahr 2019 1 Whereas whereas IN cord-028721-x6f26ahr 2019 2 tubular tubular JJ cord-028721-x6f26ahr 2019 3 hyalinization hyalinization NN cord-028721-x6f26ahr 2019 4 in in IN cord-028721-x6f26ahr 2019 5 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2019 6 's 's POS cord-028721-x6f26ahr 2019 7 syndrome syndrome NN cord-028721-x6f26ahr 2019 8 is be VBZ cord-028721-x6f26ahr 2019 9 secondary secondary JJ cord-028721-x6f26ahr 2019 10 to to IN cord-028721-x6f26ahr 2019 11 the the DT cord-028721-x6f26ahr 2019 12 effect effect NN cord-028721-x6f26ahr 2019 13 of of IN cord-028721-x6f26ahr 2019 14 pubertal pubertal JJ cord-028721-x6f26ahr 2019 15 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 2019 16 secretion secretion NN cord-028721-x6f26ahr 2019 17 on on IN cord-028721-x6f26ahr 2019 18 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2019 19 tubules tubule NNS cord-028721-x6f26ahr 2019 20 , , , cord-028721-x6f26ahr 2019 21 tubular tubular JJ cord-028721-x6f26ahr 2019 22 hyalinization hyalinization NN cord-028721-x6f26ahr 2019 23 in in IN cord-028721-x6f26ahr 2019 24 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2019 25 probably probably RB cord-028721-x6f26ahr 2019 26 results result VBZ cord-028721-x6f26ahr 2019 27 from from IN cord-028721-x6f26ahr 2019 28 the the DT cord-028721-x6f26ahr 2019 29 effect effect NN cord-028721-x6f26ahr 2019 30 of of IN cord-028721-x6f26ahr 2019 31 increased increase VBN cord-028721-x6f26ahr 2019 32 temperature temperature NN cord-028721-x6f26ahr 2019 33 on on IN cord-028721-x6f26ahr 2019 34 the the DT cord-028721-x6f26ahr 2019 35 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2019 36 tubules tubule NNS cord-028721-x6f26ahr 2019 37 . . . cord-028721-x6f26ahr 2020 1 However however RB cord-028721-x6f26ahr 2020 2 , , , cord-028721-x6f26ahr 2020 3 other other JJ cord-028721-x6f26ahr 2020 4 mechanisms mechanism NNS cord-028721-x6f26ahr 2020 5 are be VBP cord-028721-x6f26ahr 2020 6 also also RB cord-028721-x6f26ahr 2020 7 involved involve VBN cord-028721-x6f26ahr 2020 8 in in IN cord-028721-x6f26ahr 2020 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 2020 10 tubular tubular JJ cord-028721-x6f26ahr 2020 11 hyalinization hyalinization NN cord-028721-x6f26ahr 2020 12 , , , cord-028721-x6f26ahr 2020 13 including include VBG cord-028721-x6f26ahr 2020 14 obstruction obstruction NN cord-028721-x6f26ahr 2020 15 of of IN cord-028721-x6f26ahr 2020 16 sperm sperm NN cord-028721-x6f26ahr 2020 17 excretory excretory JJ cord-028721-x6f26ahr 2020 18 ducts duct NNS cord-028721-x6f26ahr 2020 19 ( ( -LRB- cord-028721-x6f26ahr 2020 20 anomalies anomaly NNS cord-028721-x6f26ahr 2020 21 in in IN cord-028721-x6f26ahr 2020 22 these these DT cord-028721-x6f26ahr 2020 23 ducts duct NNS cord-028721-x6f26ahr 2020 24 are be VBP cord-028721-x6f26ahr 2020 25 frequent frequent JJ cord-028721-x6f26ahr 2020 26 in in IN cord-028721-x6f26ahr 2020 27 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2020 28 ) ) -RRB- cord-028721-x6f26ahr 2020 29 and and CC cord-028721-x6f26ahr 2020 30 ischemia ischemia NN cord-028721-x6f26ahr 2020 31 ( ( -LRB- cord-028721-x6f26ahr 2020 32 principally principally RB cord-028721-x6f26ahr 2020 33 in in IN cord-028721-x6f26ahr 2020 34 testes testis NNS cord-028721-x6f26ahr 2020 35 that that WDT cord-028721-x6f26ahr 2020 36 could could MD cord-028721-x6f26ahr 2020 37 only only RB cord-028721-x6f26ahr 2020 38 be be VB cord-028721-x6f26ahr 2020 39 incompletely incompletely RB cord-028721-x6f26ahr 2020 40 descended descend VBN cord-028721-x6f26ahr 2020 41 by by IN cord-028721-x6f26ahr 2020 42 surgery surgery NN cord-028721-x6f26ahr 2020 43 ) ) -RRB- cord-028721-x6f26ahr 2020 44 . . . cord-028721-x6f26ahr 2021 1 Hyalinization hyalinization NN cord-028721-x6f26ahr 2021 2 caused cause VBN cord-028721-x6f26ahr 2021 3 by by IN cord-028721-x6f26ahr 2021 4 hormonal hormonal JJ cord-028721-x6f26ahr 2021 5 defi defi NNP cord-028721-x6f26ahr 2021 6 cit cit NNP cord-028721-x6f26ahr 2021 7 Hormonal Hormonal NNP cord-028721-x6f26ahr 2021 8 defi defi NNP cord-028721-x6f26ahr 2021 9 cit cit NNP cord-028721-x6f26ahr 2021 10 causes cause VBZ cord-028721-x6f26ahr 2021 11 diffuse diffuse VBP cord-028721-x6f26ahr 2021 12 tubular tubular JJ cord-028721-x6f26ahr 2021 13 hyalinization hyalinization NN cord-028721-x6f26ahr 2021 14 , , , cord-028721-x6f26ahr 2021 15 although although IN cord-028721-x6f26ahr 2021 16 the the DT cord-028721-x6f26ahr 2021 17 tubules tubule NNS cord-028721-x6f26ahr 2021 18 may may MD cord-028721-x6f26ahr 2021 19 be be VB cord-028721-x6f26ahr 2021 20 recognized recognize VBN cord-028721-x6f26ahr 2021 21 for for IN cord-028721-x6f26ahr 2021 22 a a DT cord-028721-x6f26ahr 2021 23 time time NN cord-028721-x6f26ahr 2021 24 as as IN cord-028721-x6f26ahr 2021 25 cellular cellular JJ cord-028721-x6f26ahr 2021 26 cords cord NNS cord-028721-x6f26ahr 2021 27 surrounded surround VBN cord-028721-x6f26ahr 2021 28 by by IN cord-028721-x6f26ahr 2021 29 hyaline hyaline JJ cord-028721-x6f26ahr 2021 30 material material NN cord-028721-x6f26ahr 2021 31 . . . cord-028721-x6f26ahr 2022 1 Sertoli sertoli JJ cord-028721-x6f26ahr 2022 2 cell cell NN cord-028721-x6f26ahr 2022 3 , , , cord-028721-x6f26ahr 2022 4 a a DT cord-028721-x6f26ahr 2022 5 few few JJ cord-028721-x6f26ahr 2022 6 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2022 7 , , , cord-028721-x6f26ahr 2022 8 and and CC cord-028721-x6f26ahr 2022 9 rare rare JJ cord-028721-x6f26ahr 2022 10 primary primary JJ cord-028721-x6f26ahr 2022 11 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2022 12 may may MD cord-028721-x6f26ahr 2022 13 be be VB cord-028721-x6f26ahr 2022 14 identifi identifi VBN cord-028721-x6f26ahr 2022 15 ed ed NN cord-028721-x6f26ahr 2022 16 in in IN cord-028721-x6f26ahr 2022 17 these these DT cord-028721-x6f26ahr 2022 18 cords cord NNS cord-028721-x6f26ahr 2022 19 . . . cord-028721-x6f26ahr 2023 1 When when WRB cord-028721-x6f26ahr 2023 2 hyalinization hyalinization NN cord-028721-x6f26ahr 2023 3 is be VBZ cord-028721-x6f26ahr 2023 4 complete complete JJ cord-028721-x6f26ahr 2023 5 , , , cord-028721-x6f26ahr 2023 6 only only RB cord-028721-x6f26ahr 2023 7 the the DT cord-028721-x6f26ahr 2023 8 elastic elastic JJ cord-028721-x6f26ahr 2023 9 fi fi NN cord-028721-x6f26ahr 2023 10 bers ber NNS cord-028721-x6f26ahr 2023 11 in in IN cord-028721-x6f26ahr 2023 12 the the DT cord-028721-x6f26ahr 2023 13 lamina lamina JJ cord-028721-x6f26ahr 2023 14 propria propria NNP cord-028721-x6f26ahr 2023 15 indicate indicate VBP cord-028721-x6f26ahr 2023 16 the the DT cord-028721-x6f26ahr 2023 17 structure structure NN cord-028721-x6f26ahr 2023 18 of of IN cord-028721-x6f26ahr 2023 19 the the DT cord-028721-x6f26ahr 2023 20 previously previously RB cord-028721-x6f26ahr 2023 21 normal normal JJ cord-028721-x6f26ahr 2023 22 adult adult NN cord-028721-x6f26ahr 2023 23 testis testis NN cord-028721-x6f26ahr 2023 24 . . . cord-028721-x6f26ahr 2024 1 Peritubular Peritubular NNP cord-028721-x6f26ahr 2024 2 myofi myofi NNP cord-028721-x6f26ahr 2024 3 broblasts broblasts NNP cord-028721-x6f26ahr 2024 4 decrease decrease VBP cord-028721-x6f26ahr 2024 5 in in IN cord-028721-x6f26ahr 2024 6 number number NN cord-028721-x6f26ahr 2024 7 and and CC cord-028721-x6f26ahr 2024 8 form form VB cord-028721-x6f26ahr 2024 9 a a DT cord-028721-x6f26ahr 2024 10 ring ring NN cord-028721-x6f26ahr 2024 11 at at IN cord-028721-x6f26ahr 2024 12 the the DT cord-028721-x6f26ahr 2024 13 periphery periphery NN cord-028721-x6f26ahr 2024 14 of of IN cord-028721-x6f26ahr 2024 15 the the DT cord-028721-x6f26ahr 2024 16 lamina lamina JJ cord-028721-x6f26ahr 2024 17 propria propria NN cord-028721-x6f26ahr 2024 18 . . . cord-028721-x6f26ahr 2025 1 Leydig leydig NN cord-028721-x6f26ahr 2025 2 cells cell NNS cord-028721-x6f26ahr 2025 3 disappear disappear VBP cord-028721-x6f26ahr 2025 4 as as IN cord-028721-x6f26ahr 2025 5 hyalinization hyalinization NN cord-028721-x6f26ahr 2025 6 progresses progress VBZ cord-028721-x6f26ahr 2025 7 , , , cord-028721-x6f26ahr 2025 8 and and CC cord-028721-x6f26ahr 2025 9 the the DT cord-028721-x6f26ahr 2025 10 few few JJ cord-028721-x6f26ahr 2025 11 that that WDT cord-028721-x6f26ahr 2025 12 remain remain VBP cord-028721-x6f26ahr 2025 13 have have VBP cord-028721-x6f26ahr 2025 14 pyknotic pyknotic JJ cord-028721-x6f26ahr 2025 15 nuclei nucleus NNS cord-028721-x6f26ahr 2025 16 and and CC cord-028721-x6f26ahr 2025 17 shrunken shrunken JJ cord-028721-x6f26ahr 2025 18 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2025 19 with with IN cord-028721-x6f26ahr 2025 20 abundant abundant JJ cord-028721-x6f26ahr 2025 21 lipofuscin lipofuscin NNS cord-028721-x6f26ahr 2025 22 granules granule NNS cord-028721-x6f26ahr 2025 23 . . . cord-028721-x6f26ahr 2026 1 This this DT cord-028721-x6f26ahr 2026 2 process process NN cord-028721-x6f26ahr 2026 3 manifests manifest VBZ cord-028721-x6f26ahr 2026 4 clinically clinically RB cord-028721-x6f26ahr 2026 5 as as IN cord-028721-x6f26ahr 2026 6 postpubertal postpubertal JJ cord-028721-x6f26ahr 2026 7 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2026 8 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2026 9 and and CC cord-028721-x6f26ahr 2026 10 is be VBZ cord-028721-x6f26ahr 2026 11 usually usually RB cord-028721-x6f26ahr 2026 12 caused cause VBN cord-028721-x6f26ahr 2026 13 by by IN cord-028721-x6f26ahr 2026 14 a a DT cord-028721-x6f26ahr 2026 15 lesion lesion NN cord-028721-x6f26ahr 2026 16 in in IN cord-028721-x6f26ahr 2026 17 or or CC cord-028721-x6f26ahr 2026 18 near near IN cord-028721-x6f26ahr 2026 19 the the DT cord-028721-x6f26ahr 2026 20 pituitary pituitary NN cord-028721-x6f26ahr 2026 21 , , , cord-028721-x6f26ahr 2026 22 such such JJ cord-028721-x6f26ahr 2026 23 as as IN cord-028721-x6f26ahr 2026 24 pituitary pituitary JJ cord-028721-x6f26ahr 2026 25 adenoma adenoma NN cord-028721-x6f26ahr 2026 26 , , , cord-028721-x6f26ahr 2026 27 craniopharyngioma craniopharyngioma NNP cord-028721-x6f26ahr 2026 28 , , , cord-028721-x6f26ahr 2026 29 and and CC cord-028721-x6f26ahr 2026 30 trauma trauma NN cord-028721-x6f26ahr 2026 31 to to IN cord-028721-x6f26ahr 2026 32 the the DT cord-028721-x6f26ahr 2026 33 cranial cranial JJ cord-028721-x6f26ahr 2026 34 base base NN cord-028721-x6f26ahr 2026 35 or or CC cord-028721-x6f26ahr 2026 36 sella sella NNP cord-028721-x6f26ahr 2026 37 turcica turcica NNP cord-028721-x6f26ahr 2026 38 ( ( -LRB- cord-028721-x6f26ahr 2026 39 see see VB cord-028721-x6f26ahr 2026 40 discussion discussion NN cord-028721-x6f26ahr 2026 41 on on IN cord-028721-x6f26ahr 2026 42 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2026 43 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2026 44 in in IN cord-028721-x6f26ahr 2026 45 this this DT cord-028721-x6f26ahr 2026 46 chapter chapter NN cord-028721-x6f26ahr 2026 47 ) ) -RRB- cord-028721-x6f26ahr 2026 48 . . . cord-028721-x6f26ahr 2027 1 Ischemic ischemic JJ cord-028721-x6f26ahr 2027 2 hyalinization hyalinization NN cord-028721-x6f26ahr 2028 1 Ischemic ischemic JJ cord-028721-x6f26ahr 2028 2 atrophy atrophy NN cord-028721-x6f26ahr 2028 3 is be VBZ cord-028721-x6f26ahr 2028 4 usually usually RB cord-028721-x6f26ahr 2028 5 caused cause VBN cord-028721-x6f26ahr 2028 6 by by IN cord-028721-x6f26ahr 2028 7 torsion torsion NN cord-028721-x6f26ahr 2028 8 of of IN cord-028721-x6f26ahr 2028 9 the the DT cord-028721-x6f26ahr 2028 10 spermatic spermatic JJ cord-028721-x6f26ahr 2028 11 cord cord NN cord-028721-x6f26ahr 2028 12 , , , cord-028721-x6f26ahr 2028 13 vascular vascular JJ cord-028721-x6f26ahr 2028 14 injury injury NN cord-028721-x6f26ahr 2028 15 during during IN cord-028721-x6f26ahr 2028 16 inguinal inguinal JJ cord-028721-x6f26ahr 2028 17 surgery surgery NN cord-028721-x6f26ahr 2028 18 , , , cord-028721-x6f26ahr 2028 19 914 914 CD cord-028721-x6f26ahr 2028 20 polyarteritis polyarteritis NN cord-028721-x6f26ahr 2028 21 nodosa nodosa RB cord-028721-x6f26ahr 2028 22 , , , cord-028721-x6f26ahr 2028 23 and and CC cord-028721-x6f26ahr 2028 24 severe severe JJ cord-028721-x6f26ahr 2028 25 arteriosclerosis arteriosclerosis NN cord-028721-x6f26ahr 2028 26 . . . cord-028721-x6f26ahr 2029 1 915 915 CD cord-028721-x6f26ahr 2030 1 Except except IN cord-028721-x6f26ahr 2030 2 for for IN cord-028721-x6f26ahr 2030 3 cases case NNS cord-028721-x6f26ahr 2030 4 caused cause VBN cord-028721-x6f26ahr 2030 5 by by IN cord-028721-x6f26ahr 2030 6 torsion torsion NN cord-028721-x6f26ahr 2030 7 of of IN cord-028721-x6f26ahr 2030 8 the the DT cord-028721-x6f26ahr 2030 9 cord cord NN cord-028721-x6f26ahr 2030 10 , , , cord-028721-x6f26ahr 2030 11 these these DT cord-028721-x6f26ahr 2030 12 patients patient NNS cord-028721-x6f26ahr 2030 13 usually usually RB cord-028721-x6f26ahr 2030 14 are be VBP cord-028721-x6f26ahr 2030 15 not not RB cord-028721-x6f26ahr 2030 16 referred refer VBN cord-028721-x6f26ahr 2030 17 to to IN cord-028721-x6f26ahr 2030 18 infertility infertility NN cord-028721-x6f26ahr 2030 19 clinics clinic NNS cord-028721-x6f26ahr 2030 20 . . . cord-028721-x6f26ahr 2031 1 Torsion torsion NN cord-028721-x6f26ahr 2031 2 of of IN cord-028721-x6f26ahr 2031 3 the the DT cord-028721-x6f26ahr 2031 4 spermatic spermatic JJ cord-028721-x6f26ahr 2031 5 cord cord NN cord-028721-x6f26ahr 2031 6 often often RB cord-028721-x6f26ahr 2031 7 is be VBZ cord-028721-x6f26ahr 2031 8 not not RB cord-028721-x6f26ahr 2031 9 listed list VBN cord-028721-x6f26ahr 2031 10 as as IN cord-028721-x6f26ahr 2031 11 a a DT cord-028721-x6f26ahr 2031 12 cause cause NN cord-028721-x6f26ahr 2031 13 in in IN cord-028721-x6f26ahr 2031 14 large large JJ cord-028721-x6f26ahr 2031 15 series series NN cord-028721-x6f26ahr 2031 16 of of IN cord-028721-x6f26ahr 2031 17 infertile infertile JJ cord-028721-x6f26ahr 2031 18 patients patient NNS cord-028721-x6f26ahr 2031 19 . . . cord-028721-x6f26ahr 2032 1 However however RB cord-028721-x6f26ahr 2032 2 , , , cord-028721-x6f26ahr 2032 3 follow follow NN cord-028721-x6f26ahr 2032 4 - - HYPH cord-028721-x6f26ahr 2032 5 up up NN cord-028721-x6f26ahr 2032 6 of of IN cord-028721-x6f26ahr 2032 7 men man NNS cord-028721-x6f26ahr 2032 8 with with IN cord-028721-x6f26ahr 2032 9 torsion torsion NN cord-028721-x6f26ahr 2032 10 reveals reveal VBZ cord-028721-x6f26ahr 2032 11 marked marked JJ cord-028721-x6f26ahr 2032 12 alteration alteration NN cord-028721-x6f26ahr 2032 13 in in IN cord-028721-x6f26ahr 2032 14 their -PRON- PRP$ cord-028721-x6f26ahr 2032 15 spermiograms spermiogram NNS cord-028721-x6f26ahr 2032 16 . . . cord-028721-x6f26ahr 2033 1 Several several JJ cord-028721-x6f26ahr 2033 2 hypotheses hypothesis NNS cord-028721-x6f26ahr 2033 3 have have VBP cord-028721-x6f26ahr 2033 4 been be VBN cord-028721-x6f26ahr 2033 5 offered offer VBN cord-028721-x6f26ahr 2033 6 to to TO cord-028721-x6f26ahr 2033 7 explain explain VB cord-028721-x6f26ahr 2033 8 the the DT cord-028721-x6f26ahr 2033 9 low low JJ cord-028721-x6f26ahr 2033 10 number number NN cord-028721-x6f26ahr 2033 11 of of IN cord-028721-x6f26ahr 2033 12 sperm sperm NN cord-028721-x6f26ahr 2033 13 produced produce VBN cord-028721-x6f26ahr 2033 14 by by IN cord-028721-x6f26ahr 2033 15 the the DT cord-028721-x6f26ahr 2033 16 contralateral contralateral JJ cord-028721-x6f26ahr 2033 17 normal normal JJ cord-028721-x6f26ahr 2033 18 testis testis NN cord-028721-x6f26ahr 2033 19 ; ; : cord-028721-x6f26ahr 2033 20 the the DT cord-028721-x6f26ahr 2033 21 most most RBS cord-028721-x6f26ahr 2033 22 promising promising JJ cord-028721-x6f26ahr 2033 23 include include VBP cord-028721-x6f26ahr 2033 24 response response NN cord-028721-x6f26ahr 2033 25 to to IN cord-028721-x6f26ahr 2033 26 the the DT cord-028721-x6f26ahr 2033 27 release release NN cord-028721-x6f26ahr 2033 28 of of IN cord-028721-x6f26ahr 2033 29 antigens antigen NNS cord-028721-x6f26ahr 2033 30 by by IN cord-028721-x6f26ahr 2033 31 the the DT cord-028721-x6f26ahr 2033 32 ischemic ischemic JJ cord-028721-x6f26ahr 2033 33 testis testis NN cord-028721-x6f26ahr 2033 34 , , , cord-028721-x6f26ahr 2033 35 and and CC cord-028721-x6f26ahr 2033 36 primary primary JJ cord-028721-x6f26ahr 2033 37 lesions lesion NNS cord-028721-x6f26ahr 2033 38 of of IN cord-028721-x6f26ahr 2033 39 the the DT cord-028721-x6f26ahr 2033 40 contralateral contralateral JJ cord-028721-x6f26ahr 2033 41 testis testis NN cord-028721-x6f26ahr 2033 42 916 916 CD cord-028721-x6f26ahr 2033 43 ( ( -LRB- cord-028721-x6f26ahr 2033 44 see see VB cord-028721-x6f26ahr 2033 45 discussion discussion NN cord-028721-x6f26ahr 2033 46 on on IN cord-028721-x6f26ahr 2033 47 testicular testicular JJ cord-028721-x6f26ahr 2033 48 torsion torsion NN cord-028721-x6f26ahr 2033 49 in in IN cord-028721-x6f26ahr 2033 50 this this DT cord-028721-x6f26ahr 2033 51 chapter chapter NN cord-028721-x6f26ahr 2033 52 ) ) -RRB- cord-028721-x6f26ahr 2033 53 . . . cord-028721-x6f26ahr 2034 1 Testicular testicular JJ cord-028721-x6f26ahr 2034 2 anoxia anoxia NN cord-028721-x6f26ahr 2034 3 caused cause VBN cord-028721-x6f26ahr 2034 4 by by IN cord-028721-x6f26ahr 2034 5 torsion torsion NN cord-028721-x6f26ahr 2034 6 rapidly rapidly RB cord-028721-x6f26ahr 2034 7 produces produce VBZ cord-028721-x6f26ahr 2034 8 severe severe JJ cord-028721-x6f26ahr 2034 9 lesions lesion NNS cord-028721-x6f26ahr 2034 10 that that WDT cord-028721-x6f26ahr 2034 11 are be VBP cord-028721-x6f26ahr 2034 12 irreversible irreversible JJ cord-028721-x6f26ahr 2034 13 without without IN cord-028721-x6f26ahr 2034 14 adequate adequate JJ cord-028721-x6f26ahr 2034 15 treatment treatment NN cord-028721-x6f26ahr 2034 16 . . . cord-028721-x6f26ahr 2035 1 Eight eight CD cord-028721-x6f26ahr 2035 2 hours hour NNS cord-028721-x6f26ahr 2035 3 after after IN cord-028721-x6f26ahr 2035 4 torsion torsion NN cord-028721-x6f26ahr 2035 5 , , , cord-028721-x6f26ahr 2035 6 there there EX cord-028721-x6f26ahr 2035 7 is be VBZ cord-028721-x6f26ahr 2035 8 intense intense JJ cord-028721-x6f26ahr 2035 9 hemorrhagic hemorrhagic JJ cord-028721-x6f26ahr 2035 10 infarction infarction NN cord-028721-x6f26ahr 2035 11 of of IN cord-028721-x6f26ahr 2035 12 the the DT cord-028721-x6f26ahr 2035 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2035 14 tubular tubular JJ cord-028721-x6f26ahr 2035 15 cells cell NNS cord-028721-x6f26ahr 2035 16 . . . cord-028721-x6f26ahr 2036 1 Chronic chronic JJ cord-028721-x6f26ahr 2036 2 anoxia anoxia NN cord-028721-x6f26ahr 2036 3 leads lead VBZ cord-028721-x6f26ahr 2036 4 to to IN cord-028721-x6f26ahr 2036 5 tubular tubular JJ cord-028721-x6f26ahr 2036 6 hyalinization hyalinization NN cord-028721-x6f26ahr 2036 7 and and CC cord-028721-x6f26ahr 2036 8 loss loss NN cord-028721-x6f26ahr 2036 9 of of IN cord-028721-x6f26ahr 2036 10 Leydig leydig NN cord-028721-x6f26ahr 2036 11 cells cell NNS cord-028721-x6f26ahr 2036 12 ( ( -LRB- cord-028721-x6f26ahr 2036 13 Fig fig NN cord-028721-x6f26ahr 2036 14 . . . cord-028721-x6f26ahr 2036 15 _SP cord-028721-x6f26ahr 2037 1 12 12 CD cord-028721-x6f26ahr 2037 2 - - SYM cord-028721-x6f26ahr 2037 3 93 93 CD cord-028721-x6f26ahr 2037 4 ) ) -RRB- cord-028721-x6f26ahr 2037 5 . . . cord-028721-x6f26ahr 2038 1 Testicular testicular JJ cord-028721-x6f26ahr 2038 2 atrophy atrophy NN cord-028721-x6f26ahr 2038 3 secondary secondary JJ cord-028721-x6f26ahr 2038 4 to to IN cord-028721-x6f26ahr 2038 5 inguinal inguinal JJ cord-028721-x6f26ahr 2038 6 hernia hernia NN cord-028721-x6f26ahr 2038 7 surgery surgery NN cord-028721-x6f26ahr 2038 8 occurs occur VBZ cord-028721-x6f26ahr 2038 9 in in IN cord-028721-x6f26ahr 2038 10 0.03 0.03 CD cord-028721-x6f26ahr 2038 11 - - SYM cord-028721-x6f26ahr 2038 12 0.5 0.5 CD cord-028721-x6f26ahr 2038 13 % % NN cord-028721-x6f26ahr 2038 14 of of IN cord-028721-x6f26ahr 2038 15 patents patent NNS cord-028721-x6f26ahr 2038 16 in in IN cord-028721-x6f26ahr 2038 17 the the DT cord-028721-x6f26ahr 2038 18 fi fi NN cord-028721-x6f26ahr 2038 19 rst rst NN cord-028721-x6f26ahr 2038 20 repair repair NN cord-028721-x6f26ahr 2038 21 , , , cord-028721-x6f26ahr 2038 22 and and CC cord-028721-x6f26ahr 2038 23 in in IN cord-028721-x6f26ahr 2038 24 0.8 0.8 CD cord-028721-x6f26ahr 2038 25 - - SYM cord-028721-x6f26ahr 2038 26 5 5 CD cord-028721-x6f26ahr 2038 27 % % NN cord-028721-x6f26ahr 2038 28 in in IN cord-028721-x6f26ahr 2038 29 surgery surgery NN cord-028721-x6f26ahr 2038 30 for for IN cord-028721-x6f26ahr 2038 31 recurrent recurrent JJ cord-028721-x6f26ahr 2038 32 hernia hernia NN cord-028721-x6f26ahr 2038 33 . . . cord-028721-x6f26ahr 2039 1 Atrophy atrophy NN cord-028721-x6f26ahr 2039 2 is be VBZ cord-028721-x6f26ahr 2039 3 most most RBS cord-028721-x6f26ahr 2039 4 fre- fre- JJ cord-028721-x6f26ahr 2040 1 Postobstructive postobstructive JJ cord-028721-x6f26ahr 2040 2 hyalinization hyalinization NN cord-028721-x6f26ahr 2040 3 Obstruction obstruction NN cord-028721-x6f26ahr 2040 4 of of IN cord-028721-x6f26ahr 2040 5 sperm sperm NN cord-028721-x6f26ahr 2040 6 excretory excretory JJ cord-028721-x6f26ahr 2040 7 ducts duct NNS cord-028721-x6f26ahr 2040 8 may may MD cord-028721-x6f26ahr 2040 9 cause cause VB cord-028721-x6f26ahr 2040 10 atrophy atrophy NN cord-028721-x6f26ahr 2040 11 of of IN cord-028721-x6f26ahr 2040 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 2040 13 tubules tubule NNS cord-028721-x6f26ahr 2040 14 . . . cord-028721-x6f26ahr 2041 1 In in IN cord-028721-x6f26ahr 2041 2 order order NN cord-028721-x6f26ahr 2041 3 to to TO cord-028721-x6f26ahr 2041 4 produce produce VB cord-028721-x6f26ahr 2041 5 tubular tubular JJ cord-028721-x6f26ahr 2041 6 hyalinization hyalinization NN cord-028721-x6f26ahr 2041 7 , , , cord-028721-x6f26ahr 2041 8 the the DT cord-028721-x6f26ahr 2041 9 obstruction obstruction NN cord-028721-x6f26ahr 2041 10 must must MD cord-028721-x6f26ahr 2041 11 be be VB cord-028721-x6f26ahr 2041 12 close close JJ cord-028721-x6f26ahr 2041 13 to to IN cord-028721-x6f26ahr 2041 14 the the DT cord-028721-x6f26ahr 2041 15 testis testis NN cord-028721-x6f26ahr 2041 16 because because IN cord-028721-x6f26ahr 2041 17 the the DT cord-028721-x6f26ahr 2041 18 ductuli ductuli NNP cord-028721-x6f26ahr 2041 19 efferentes efferentes NNP cord-028721-x6f26ahr 2041 20 in in IN cord-028721-x6f26ahr 2041 21 the the DT cord-028721-x6f26ahr 2041 22 caput caput NN cord-028721-x6f26ahr 2041 23 epididymis epididymis NN cord-028721-x6f26ahr 2041 24 absorb absorb VB cord-028721-x6f26ahr 2041 25 about about RB cord-028721-x6f26ahr 2041 26 90 90 CD cord-028721-x6f26ahr 2041 27 % % NN cord-028721-x6f26ahr 2041 28 of of IN cord-028721-x6f26ahr 2041 29 tubular tubular JJ cord-028721-x6f26ahr 2041 30 fl fl JJ cord-028721-x6f26ahr 2041 31 uid uid NN cord-028721-x6f26ahr 2041 32 and and CC cord-028721-x6f26ahr 2041 33 protect protect VB cord-028721-x6f26ahr 2041 34 the the DT cord-028721-x6f26ahr 2041 35 testis testis NN cord-028721-x6f26ahr 2041 36 from from IN cord-028721-x6f26ahr 2041 37 excessive excessive JJ cord-028721-x6f26ahr 2041 38 intratubular intratubular JJ cord-028721-x6f26ahr 2041 39 pressure pressure NN cord-028721-x6f26ahr 2041 40 . . . cord-028721-x6f26ahr 2042 1 Obstructive obstructive JJ cord-028721-x6f26ahr 2042 2 tubular tubular JJ cord-028721-x6f26ahr 2042 3 hyalinization hyalinization NN cord-028721-x6f26ahr 2042 4 is be VBZ cord-028721-x6f26ahr 2042 5 usually usually RB cord-028721-x6f26ahr 2042 6 focal focal JJ cord-028721-x6f26ahr 2042 7 and and CC cord-028721-x6f26ahr 2042 8 secondary secondary JJ cord-028721-x6f26ahr 2042 9 to to IN cord-028721-x6f26ahr 2042 10 varicocele varicocele NN cord-028721-x6f26ahr 2042 11 and and CC cord-028721-x6f26ahr 2042 12 other other JJ cord-028721-x6f26ahr 2042 13 disorders disorder NNS cord-028721-x6f26ahr 2042 14 involving involve VBG cord-028721-x6f26ahr 2042 15 dilation dilation NN cord-028721-x6f26ahr 2042 16 of of IN cord-028721-x6f26ahr 2042 17 the the DT cord-028721-x6f26ahr 2042 18 channels channel NNS cord-028721-x6f26ahr 2042 19 of of IN cord-028721-x6f26ahr 2042 20 the the DT cord-028721-x6f26ahr 2042 21 rete rete NN cord-028721-x6f26ahr 2042 22 testis testis NN cord-028721-x6f26ahr 2042 23 . . . cord-028721-x6f26ahr 2043 1 These these DT cord-028721-x6f26ahr 2043 2 may may MD cord-028721-x6f26ahr 2043 3 be be VB cord-028721-x6f26ahr 2043 4 congenital congenital JJ cord-028721-x6f26ahr 2043 5 , , , cord-028721-x6f26ahr 2043 6 as as IN cord-028721-x6f26ahr 2043 7 in in IN cord-028721-x6f26ahr 2043 8 epididymis epididymis NN cord-028721-x6f26ahr 2043 9 - - HYPH cord-028721-x6f26ahr 2043 10 testis testis NN cord-028721-x6f26ahr 2043 11 dissociation dissociation NN cord-028721-x6f26ahr 2043 12 , , , cord-028721-x6f26ahr 2043 13 or or CC cord-028721-x6f26ahr 2043 14 acquired acquire VBD cord-028721-x6f26ahr 2043 15 , , , cord-028721-x6f26ahr 2043 16 as as IN cord-028721-x6f26ahr 2043 17 in in IN cord-028721-x6f26ahr 2043 18 rete rete NNP cord-028721-x6f26ahr 2043 19 testis testis NN cord-028721-x6f26ahr 2043 20 dilation dilation NN cord-028721-x6f26ahr 2043 21 secondary secondary JJ cord-028721-x6f26ahr 2043 22 to to IN cord-028721-x6f26ahr 2043 23 epididymal epididymal JJ cord-028721-x6f26ahr 2043 24 atrophy atrophy NN cord-028721-x6f26ahr 2043 25 caused cause VBN cord-028721-x6f26ahr 2043 26 by by IN cord-028721-x6f26ahr 2043 27 arteritis arteritis NN cord-028721-x6f26ahr 2043 28 , , , cord-028721-x6f26ahr 2043 29 arteriosclerosis arteriosclerosis NN cord-028721-x6f26ahr 2043 30 , , , cord-028721-x6f26ahr 2043 31 or or CC cord-028721-x6f26ahr 2043 32 androgen androgen NN cord-028721-x6f26ahr 2043 33 insuffi insuffi NNP cord-028721-x6f26ahr 2043 34 ciency ciency NN cord-028721-x6f26ahr 2043 35 . . . cord-028721-x6f26ahr 2044 1 Obstructive obstructive JJ cord-028721-x6f26ahr 2044 2 tubular tubular JJ cord-028721-x6f26ahr 2044 3 hyalinization hyalinization NN cord-028721-x6f26ahr 2044 4 also also RB cord-028721-x6f26ahr 2044 5 occurs occur VBZ cord-028721-x6f26ahr 2044 6 in in IN cord-028721-x6f26ahr 2044 7 the the DT cord-028721-x6f26ahr 2044 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 2044 9 tubules tubule NNS cord-028721-x6f26ahr 2044 10 at at IN cord-028721-x6f26ahr 2044 11 the the DT cord-028721-x6f26ahr 2044 12 periphery periphery NN cord-028721-x6f26ahr 2044 13 of of IN cord-028721-x6f26ahr 2044 14 the the DT cord-028721-x6f26ahr 2044 15 testis testis NN cord-028721-x6f26ahr 2044 16 in in IN cord-028721-x6f26ahr 2044 17 patients patient NNS cord-028721-x6f26ahr 2044 18 who who WP cord-028721-x6f26ahr 2044 19 have have VBP cord-028721-x6f26ahr 2044 20 had have VBN cord-028721-x6f26ahr 2044 21 orchitis orchiti NNS cord-028721-x6f26ahr 2044 22 . . . cord-028721-x6f26ahr 2045 1 917 917 CD cord-028721-x6f26ahr 2045 2 Obstructive obstructive JJ cord-028721-x6f26ahr 2045 3 hyalinization hyalinization NN cord-028721-x6f26ahr 2045 4 has have VBZ cord-028721-x6f26ahr 2045 5 a a DT cord-028721-x6f26ahr 2045 6 mosaic mosaic JJ cord-028721-x6f26ahr 2045 7 distribution distribution NN cord-028721-x6f26ahr 2045 8 : : : cord-028721-x6f26ahr 2045 9 lobules lobule NNS cord-028721-x6f26ahr 2045 10 of of IN cord-028721-x6f26ahr 2045 11 completely completely RB cord-028721-x6f26ahr 2045 12 hyalinized hyalinize VBN cord-028721-x6f26ahr 2045 13 tubules tubule NNS cord-028721-x6f26ahr 2045 14 are be VBP cord-028721-x6f26ahr 2045 15 intermingled intermingle VBN cord-028721-x6f26ahr 2045 16 with with IN cord-028721-x6f26ahr 2045 17 lobules lobule NNS cord-028721-x6f26ahr 2045 18 of of IN cord-028721-x6f26ahr 2045 19 normal normal JJ cord-028721-x6f26ahr 2045 20 tubules tubule NNS cord-028721-x6f26ahr 2045 21 ( ( -LRB- cord-028721-x6f26ahr 2045 22 Fig Fig NNP cord-028721-x6f26ahr 2045 23 . . . cord-028721-x6f26ahr 2045 24 12 12 CD cord-028721-x6f26ahr 2045 25 - - SYM cord-028721-x6f26ahr 2045 26 94 94 CD cord-028721-x6f26ahr 2045 27 ) ) -RRB- cord-028721-x6f26ahr 2045 28 . . . cord-028721-x6f26ahr 2046 1 The the DT cord-028721-x6f26ahr 2046 2 diameter diameter NN cord-028721-x6f26ahr 2046 3 of of IN cord-028721-x6f26ahr 2046 4 the the DT cord-028721-x6f26ahr 2046 5 hyalinized hyalinize VBN cord-028721-x6f26ahr 2046 6 tubules tubule NNS cord-028721-x6f26ahr 2046 7 is be VBZ cord-028721-x6f26ahr 2046 8 not not RB cord-028721-x6f26ahr 2046 9 as as RB cord-028721-x6f26ahr 2046 10 small small JJ cord-028721-x6f26ahr 2046 11 as as IN cord-028721-x6f26ahr 2046 12 in in IN cord-028721-x6f26ahr 2046 13 other other JJ cord-028721-x6f26ahr 2046 14 causes cause NNS cord-028721-x6f26ahr 2046 15 of of IN cord-028721-x6f26ahr 2046 16 hyalinization hyalinization NN cord-028721-x6f26ahr 2046 17 , , , cord-028721-x6f26ahr 2046 18 and and CC cord-028721-x6f26ahr 2046 19 the the DT cord-028721-x6f26ahr 2046 20 tubules tubule NNS cord-028721-x6f26ahr 2046 21 occasionally occasionally RB cord-028721-x6f26ahr 2046 22 contain contain VBP cord-028721-x6f26ahr 2046 23 Sertoli sertoli JJ cord-028721-x6f26ahr 2046 24 cells cell NNS cord-028721-x6f26ahr 2046 25 . . . cord-028721-x6f26ahr 2047 1 In in IN cord-028721-x6f26ahr 2047 2 the the DT cord-028721-x6f26ahr 2047 3 centers center NNS cord-028721-x6f26ahr 2047 4 of of IN cord-028721-x6f26ahr 2047 5 many many JJ cord-028721-x6f26ahr 2047 6 of of IN cord-028721-x6f26ahr 2047 7 the the DT cord-028721-x6f26ahr 2047 8 tubules tubule NNS cord-028721-x6f26ahr 2047 9 there there EX cord-028721-x6f26ahr 2047 10 is be VBZ cord-028721-x6f26ahr 2047 11 a a DT cord-028721-x6f26ahr 2047 12 small small JJ cord-028721-x6f26ahr 2047 13 lumen lumen NN cord-028721-x6f26ahr 2047 14 or or CC cord-028721-x6f26ahr 2047 15 vacuole vacuole NN cord-028721-x6f26ahr 2047 16 , , , cord-028721-x6f26ahr 2047 17 the the DT cord-028721-x6f26ahr 2047 18 latter latter JJ cord-028721-x6f26ahr 2047 19 in in IN cord-028721-x6f26ahr 2047 20 the the DT cord-028721-x6f26ahr 2047 21 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2047 22 of of IN cord-028721-x6f26ahr 2047 23 a a DT cord-028721-x6f26ahr 2047 24 residual residual JJ cord-028721-x6f26ahr 2047 25 Sertoli sertoli JJ cord-028721-x6f26ahr 2047 26 cell cell NN cord-028721-x6f26ahr 2047 27 . . . cord-028721-x6f26ahr 2048 1 918 918 CD cord-028721-x6f26ahr 2049 1 The the DT cord-028721-x6f26ahr 2049 2 lamina lamina JJ cord-028721-x6f26ahr 2049 3 propria propria NN cord-028721-x6f26ahr 2049 4 is be VBZ cord-028721-x6f26ahr 2049 5 thick thick JJ cord-028721-x6f26ahr 2049 6 and and CC cord-028721-x6f26ahr 2049 7 contains contain VBZ cord-028721-x6f26ahr 2049 8 hypertrophic hypertrophic JJ cord-028721-x6f26ahr 2049 9 peritubular peritubular JJ cord-028721-x6f26ahr 2049 10 cells cell NNS cord-028721-x6f26ahr 2049 11 and and CC cord-028721-x6f26ahr 2049 12 abundant abundant JJ cord-028721-x6f26ahr 2049 13 extracellular extracellular JJ cord-028721-x6f26ahr 2049 14 material material NN cord-028721-x6f26ahr 2049 15 . . . cord-028721-x6f26ahr 2050 1 Finally finally RB cord-028721-x6f26ahr 2050 2 , , , cord-028721-x6f26ahr 2050 3 the the DT cord-028721-x6f26ahr 2050 4 peritubular peritubular NNP cord-028721-x6f26ahr 2050 5 cells cell VBZ cord-028721-x6f26ahr 2050 6 dedifferentiate dedifferentiate NNP cord-028721-x6f26ahr 2050 7 and and CC cord-028721-x6f26ahr 2050 8 only only RB cord-028721-x6f26ahr 2050 9 fi fi NN cord-028721-x6f26ahr 2050 10 broblasts broblast NNS cord-028721-x6f26ahr 2050 11 remain remain VBP cord-028721-x6f26ahr 2050 12 . . . cord-028721-x6f26ahr 2051 1 919 919 CD cord-028721-x6f26ahr 2052 1 The the DT cord-028721-x6f26ahr 2052 2 interstitium interstitium NN cord-028721-x6f26ahr 2052 3 contains contain VBZ cord-028721-x6f26ahr 2052 4 a a DT cord-028721-x6f26ahr 2052 5 normal normal JJ cord-028721-x6f26ahr 2052 6 number number NN cord-028721-x6f26ahr 2052 7 of of IN cord-028721-x6f26ahr 2052 8 Leydig Leydig NNP cord-028721-x6f26ahr 2052 9 cells cell NNS cord-028721-x6f26ahr 2052 10 forming form VBG cord-028721-x6f26ahr 2052 11 small small JJ cord-028721-x6f26ahr 2052 12 clusters cluster NNS cord-028721-x6f26ahr 2052 13 , , , cord-028721-x6f26ahr 2052 14 some some DT cord-028721-x6f26ahr 2052 15 of of IN cord-028721-x6f26ahr 2052 16 which which WDT cord-028721-x6f26ahr 2052 17 are be VBP cord-028721-x6f26ahr 2052 18 among among IN cord-028721-x6f26ahr 2052 19 hyalinized hyalinize VBN cord-028721-x6f26ahr 2052 20 tubules tubule NNS cord-028721-x6f26ahr 2052 21 . . . cord-028721-x6f26ahr 2053 1 This this DT cord-028721-x6f26ahr 2053 2 is be VBZ cord-028721-x6f26ahr 2053 3 not not RB cord-028721-x6f26ahr 2053 4 seen see VBN cord-028721-x6f26ahr 2053 5 in in IN cord-028721-x6f26ahr 2053 6 other other JJ cord-028721-x6f26ahr 2053 7 patterns pattern NNS cord-028721-x6f26ahr 2053 8 such such JJ cord-028721-x6f26ahr 2053 9 as as IN cord-028721-x6f26ahr 2053 10 ischemic ischemic JJ cord-028721-x6f26ahr 2053 11 hyalinization hyalinization NN cord-028721-x6f26ahr 2053 12 . . . cord-028721-x6f26ahr 2054 1 In in IN cord-028721-x6f26ahr 2054 2 addition addition NN cord-028721-x6f26ahr 2054 3 , , , cord-028721-x6f26ahr 2054 4 dilated dilated JJ cord-028721-x6f26ahr 2054 5 veins vein NNS cord-028721-x6f26ahr 2054 6 with with IN cord-028721-x6f26ahr 2054 7 eccentrically eccentrically RB cord-028721-x6f26ahr 2054 8 hyalinized hyalinize VBN cord-028721-x6f26ahr 2054 9 walls wall NNS cord-028721-x6f26ahr 2054 10 can can MD cord-028721-x6f26ahr 2054 11 be be VB cord-028721-x6f26ahr 2054 12 seen see VBN cord-028721-x6f26ahr 2054 13 in in IN cord-028721-x6f26ahr 2054 14 testes testis NNS cord-028721-x6f26ahr 2054 15 associated associate VBN cord-028721-x6f26ahr 2054 16 with with IN cord-028721-x6f26ahr 2054 17 varicocele varicocele NN cord-028721-x6f26ahr 2054 18 . . . cord-028721-x6f26ahr 2055 1 This this DT cord-028721-x6f26ahr 2055 2 lobular lobular JJ cord-028721-x6f26ahr 2055 3 pattern pattern NN cord-028721-x6f26ahr 2055 4 of of IN cord-028721-x6f26ahr 2055 5 tubular tubular JJ cord-028721-x6f26ahr 2055 6 atrophy atrophy NN cord-028721-x6f26ahr 2055 7 causes cause VBZ cord-028721-x6f26ahr 2055 8 a a DT cord-028721-x6f26ahr 2055 9 peculiar peculiar JJ cord-028721-x6f26ahr 2055 10 ultrasound ultrasound NN cord-028721-x6f26ahr 2055 11 image image NN cord-028721-x6f26ahr 2055 12 which which WDT cord-028721-x6f26ahr 2055 13 has have VBZ cord-028721-x6f26ahr 2055 14 been be VBN cord-028721-x6f26ahr 2055 15 described describe VBN cord-028721-x6f26ahr 2055 16 as as IN cord-028721-x6f26ahr 2055 17 a a DT cord-028721-x6f26ahr 2055 18 striated striated JJ cord-028721-x6f26ahr 2055 19 pattern pattern NN cord-028721-x6f26ahr 2055 20 . . . cord-028721-x6f26ahr 2056 1 920 920 CD cord-028721-x6f26ahr 2056 2 , , , cord-028721-x6f26ahr 2056 3 921 921 CD cord-028721-x6f26ahr 2056 4 Postinfl Postinfl NNP cord-028721-x6f26ahr 2056 5 ammatory ammatory NN cord-028721-x6f26ahr 2056 6 hyalinization hyalinization NN cord-028721-x6f26ahr 2057 1 Many many JJ cord-028721-x6f26ahr 2057 2 infections infection NNS cord-028721-x6f26ahr 2057 3 of of IN cord-028721-x6f26ahr 2057 4 the the DT cord-028721-x6f26ahr 2057 5 testis testis NN cord-028721-x6f26ahr 2057 6 cause cause VB cord-028721-x6f26ahr 2057 7 irreversible irreversible JJ cord-028721-x6f26ahr 2057 8 lesions lesion NNS cord-028721-x6f26ahr 2057 9 in in IN cord-028721-x6f26ahr 2057 10 the the DT cord-028721-x6f26ahr 2057 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 2057 12 tubules tubule NNS cord-028721-x6f26ahr 2057 13 . . . cord-028721-x6f26ahr 2058 1 In in IN cord-028721-x6f26ahr 2058 2 bacterial bacterial JJ cord-028721-x6f26ahr 2058 3 infection infection NN cord-028721-x6f26ahr 2058 4 the the DT cord-028721-x6f26ahr 2058 5 epididymis epididymis NN cord-028721-x6f26ahr 2058 6 is be VBZ cord-028721-x6f26ahr 2058 7 usually usually RB cord-028721-x6f26ahr 2058 8 involved involve VBN cord-028721-x6f26ahr 2058 9 , , , cord-028721-x6f26ahr 2058 10 resulting result VBG cord-028721-x6f26ahr 2058 11 in in IN cord-028721-x6f26ahr 2058 12 obstructive obstructive JJ cord-028721-x6f26ahr 2058 13 azoospermia azoospermia NN cord-028721-x6f26ahr 2058 14 . . . cord-028721-x6f26ahr 2059 1 In in IN cord-028721-x6f26ahr 2059 2 viral viral JJ cord-028721-x6f26ahr 2059 3 infection infection NN cord-028721-x6f26ahr 2059 4 the the DT cord-028721-x6f26ahr 2059 5 testis testis NN cord-028721-x6f26ahr 2059 6 is be VBZ cord-028721-x6f26ahr 2059 7 often often RB cord-028721-x6f26ahr 2059 8 affected affect VBN cord-028721-x6f26ahr 2059 9 , , , cord-028721-x6f26ahr 2059 10 even even RB cord-028721-x6f26ahr 2059 11 without without IN cord-028721-x6f26ahr 2059 12 symptoms symptom NNS cord-028721-x6f26ahr 2059 13 . . . cord-028721-x6f26ahr 2060 1 Two two CD cord-028721-x6f26ahr 2060 2 types type NNS cord-028721-x6f26ahr 2060 3 of of IN cord-028721-x6f26ahr 2060 4 viral viral JJ cord-028721-x6f26ahr 2060 5 orchitis orchiti NNS cord-028721-x6f26ahr 2060 6 often often RB cord-028721-x6f26ahr 2060 7 cause cause VBP cord-028721-x6f26ahr 2060 8 infertility infertility NN cord-028721-x6f26ahr 2060 9 , , , cord-028721-x6f26ahr 2060 10 including include VBG cord-028721-x6f26ahr 2060 11 mumps mumps NN cord-028721-x6f26ahr 2060 12 orchitis orchitis NN cord-028721-x6f26ahr 2060 13 and and CC cord-028721-x6f26ahr 2060 14 Coxsackie Coxsackie NNP cord-028721-x6f26ahr 2060 15 B B NNP cord-028721-x6f26ahr 2060 16 orchitis orchitis NN cord-028721-x6f26ahr 2060 17 . . . cord-028721-x6f26ahr 2061 1 Tubular tubular JJ cord-028721-x6f26ahr 2061 2 atrophy atrophy NN cord-028721-x6f26ahr 2061 3 caused cause VBN cord-028721-x6f26ahr 2061 4 by by IN cord-028721-x6f26ahr 2061 5 viral viral JJ cord-028721-x6f26ahr 2061 6 infection infection NN cord-028721-x6f26ahr 2061 7 has have VBZ cord-028721-x6f26ahr 2061 8 a a DT cord-028721-x6f26ahr 2061 9 mosaic mosaic JJ cord-028721-x6f26ahr 2061 10 topography topography NN cord-028721-x6f26ahr 2061 11 in in IN cord-028721-x6f26ahr 2061 12 which which WDT cord-028721-x6f26ahr 2061 13 hyalinized hyalinize VBN cord-028721-x6f26ahr 2061 14 and and CC cord-028721-x6f26ahr 2061 15 normal normal JJ cord-028721-x6f26ahr 2061 16 tubules tubule NNS cord-028721-x6f26ahr 2061 17 are be VBP cord-028721-x6f26ahr 2061 18 intermingled intermingle VBN cord-028721-x6f26ahr 2061 19 . . . cord-028721-x6f26ahr 2062 1 In in IN cord-028721-x6f26ahr 2062 2 fully fully RB cord-028721-x6f26ahr 2062 3 hyalinized hyalinize VBN cord-028721-x6f26ahr 2062 4 tubules tubule NNS cord-028721-x6f26ahr 2062 5 , , , cord-028721-x6f26ahr 2062 6 the the DT cord-028721-x6f26ahr 2062 7 only only JJ cord-028721-x6f26ahr 2062 8 recognizable recognizable JJ cord-028721-x6f26ahr 2062 9 cells cell NNS cord-028721-x6f26ahr 2062 10 are be VBP cord-028721-x6f26ahr 2062 11 peritubular peritubular JJ cord-028721-x6f26ahr 2062 12 cells cell NNS cord-028721-x6f26ahr 2062 13 that that WDT cord-028721-x6f26ahr 2062 14 form form VBP cord-028721-x6f26ahr 2062 15 an an DT cord-028721-x6f26ahr 2062 16 incomplete incomplete JJ cord-028721-x6f26ahr 2062 17 , , , cord-028721-x6f26ahr 2062 18 peripheral peripheral JJ cord-028721-x6f26ahr 2062 19 ring ring NN cord-028721-x6f26ahr 2062 20 around around IN cord-028721-x6f26ahr 2062 21 the the DT cord-028721-x6f26ahr 2062 22 hyalinized hyalinize VBN cord-028721-x6f26ahr 2062 23 material material NN cord-028721-x6f26ahr 2062 24 . . . cord-028721-x6f26ahr 2063 1 The the DT cord-028721-x6f26ahr 2063 2 presence presence NN cord-028721-x6f26ahr 2063 3 of of IN cord-028721-x6f26ahr 2063 4 elastic elastic JJ cord-028721-x6f26ahr 2063 5 fi fi NN cord-028721-x6f26ahr 2063 6 bers ber NNS cord-028721-x6f26ahr 2063 7 in in IN cord-028721-x6f26ahr 2063 8 these these DT cord-028721-x6f26ahr 2063 9 tubules tubule NNS cord-028721-x6f26ahr 2063 10 distinguishes distinguish VBZ cord-028721-x6f26ahr 2063 11 this this DT cord-028721-x6f26ahr 2063 12 from from IN cord-028721-x6f26ahr 2063 13 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2063 14 hyalinization hyalinization NN cord-028721-x6f26ahr 2063 15 . . . cord-028721-x6f26ahr 2064 1 Leydig leydig NN cord-028721-x6f26ahr 2064 2 cells cell NNS cord-028721-x6f26ahr 2064 3 form form VBP cord-028721-x6f26ahr 2064 4 clusters cluster NNS cord-028721-x6f26ahr 2064 5 of of IN cord-028721-x6f26ahr 2064 6 variable variable JJ cord-028721-x6f26ahr 2064 7 size size NN cord-028721-x6f26ahr 2064 8 , , , cord-028721-x6f26ahr 2064 9 but but CC cord-028721-x6f26ahr 2064 10 their -PRON- PRP$ cord-028721-x6f26ahr 2064 11 total total JJ cord-028721-x6f26ahr 2064 12 number number NN cord-028721-x6f26ahr 2064 13 is be VBZ cord-028721-x6f26ahr 2064 14 normal normal JJ cord-028721-x6f26ahr 2064 15 . . . cord-028721-x6f26ahr 2065 1 In in IN cord-028721-x6f26ahr 2065 2 bacterial bacterial JJ cord-028721-x6f26ahr 2065 3 infection infection NN cord-028721-x6f26ahr 2065 4 the the DT cord-028721-x6f26ahr 2065 5 pattern pattern NN cord-028721-x6f26ahr 2065 6 of of IN cord-028721-x6f26ahr 2065 7 tubular tubular JJ cord-028721-x6f26ahr 2065 8 hyalinization hyalinization NN cord-028721-x6f26ahr 2065 9 is be VBZ cord-028721-x6f26ahr 2065 10 variable variable JJ cord-028721-x6f26ahr 2065 11 . . . cord-028721-x6f26ahr 2066 1 Tubular tubular JJ cord-028721-x6f26ahr 2066 2 atrophy atrophy NN cord-028721-x6f26ahr 2066 3 of of IN cord-028721-x6f26ahr 2066 4 unknown unknown JJ cord-028721-x6f26ahr 2066 5 etiology etiology NN cord-028721-x6f26ahr 2066 6 may may MD cord-028721-x6f26ahr 2066 7 be be VB cord-028721-x6f26ahr 2066 8 caused cause VBN cord-028721-x6f26ahr 2066 9 by by IN cord-028721-x6f26ahr 2066 10 an an DT cord-028721-x6f26ahr 2066 11 autoimmune autoimmune JJ cord-028721-x6f26ahr 2066 12 response response NN cord-028721-x6f26ahr 2066 13 . . . cord-028721-x6f26ahr 2067 1 This this DT cord-028721-x6f26ahr 2067 2 appears appear VBZ cord-028721-x6f26ahr 2067 3 to to TO cord-028721-x6f26ahr 2067 4 occur occur VB cord-028721-x6f26ahr 2067 5 in in IN cord-028721-x6f26ahr 2067 6 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2067 7 associated associate VBN cord-028721-x6f26ahr 2067 8 with with IN cord-028721-x6f26ahr 2067 9 disorders disorder NNS cord-028721-x6f26ahr 2067 10 in in IN cord-028721-x6f26ahr 2067 11 other other JJ cord-028721-x6f26ahr 2067 12 endocrine endocrine JJ cord-028721-x6f26ahr 2067 13 glands gland NNS cord-028721-x6f26ahr 2067 14 , , , cord-028721-x6f26ahr 2067 15 such such JJ cord-028721-x6f26ahr 2067 16 as as IN cord-028721-x6f26ahr 2067 17 Addison Addison NNP cord-028721-x6f26ahr 2067 18 's 's POS cord-028721-x6f26ahr 2067 19 disease disease NN cord-028721-x6f26ahr 2067 20 associated associate VBN cord-028721-x6f26ahr 2067 21 with with IN cord-028721-x6f26ahr 2067 22 gonadal gonadal JJ cord-028721-x6f26ahr 2067 23 insufficiency insufficiency NN cord-028721-x6f26ahr 2067 24 ; ; : cord-028721-x6f26ahr 2067 25 adrenal adrenal JJ cord-028721-x6f26ahr 2067 26 - - HYPH cord-028721-x6f26ahr 2067 27 thyroid thyroid NN cord-028721-x6f26ahr 2067 28 - - HYPH cord-028721-x6f26ahr 2067 29 gonadal gonadal JJ cord-028721-x6f26ahr 2067 30 insuffi insuffi NN cord-028721-x6f26ahr 2067 31 ciency ciency NNP cord-028721-x6f26ahr 2067 32 ; ; : cord-028721-x6f26ahr 2067 33 and and CC cord-028721-x6f26ahr 2067 34 the the DT cord-028721-x6f26ahr 2067 35 association association NN cord-028721-x6f26ahr 2067 36 of of IN cord-028721-x6f26ahr 2067 37 diabetes diabetes NNP cord-028721-x6f26ahr 2067 38 , , , cord-028721-x6f26ahr 2067 39 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2067 40 , , , cord-028721-x6f26ahr 2067 41 adrenal adrenal JJ cord-028721-x6f26ahr 2067 42 insuffi insuffi NNP cord-028721-x6f26ahr 2067 43 ciency ciency NNP cord-028721-x6f26ahr 2067 44 , , , cord-028721-x6f26ahr 2067 45 and and CC cord-028721-x6f26ahr 2067 46 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 2067 47 . . . cord-028721-x6f26ahr 2068 1 The the DT cord-028721-x6f26ahr 2068 2 testicular testicular JJ cord-028721-x6f26ahr 2068 3 lesions lesion NNS cord-028721-x6f26ahr 2068 4 are be VBP cord-028721-x6f26ahr 2068 5 morphologically morphologically RB cord-028721-x6f26ahr 2068 6 similar similar JJ cord-028721-x6f26ahr 2068 7 to to IN cord-028721-x6f26ahr 2068 8 those those DT cord-028721-x6f26ahr 2068 9 seen see VBN cord-028721-x6f26ahr 2068 10 in in IN cord-028721-x6f26ahr 2068 11 the the DT cord-028721-x6f26ahr 2068 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 2068 13 tubules tubule NNS cord-028721-x6f26ahr 2068 14 at at IN cord-028721-x6f26ahr 2068 15 the the DT cord-028721-x6f26ahr 2068 16 periphery periphery NN cord-028721-x6f26ahr 2068 17 of of IN cord-028721-x6f26ahr 2068 18 germ germ NN cord-028721-x6f26ahr 2068 19 cell cell NN cord-028721-x6f26ahr 2068 20 tumor tumor NN cord-028721-x6f26ahr 2068 21 and and CC cord-028721-x6f26ahr 2068 22 in in IN cord-028721-x6f26ahr 2068 23 testes testis NNS cord-028721-x6f26ahr 2068 24 with with IN cord-028721-x6f26ahr 2068 25 burn burn NN cord-028721-x6f26ahr 2068 26 - - HYPH cord-028721-x6f26ahr 2068 27 out out RP cord-028721-x6f26ahr 2068 28 germinal germinal JJ cord-028721-x6f26ahr 2068 29 cancer cancer NN cord-028721-x6f26ahr 2068 30 . . . cord-028721-x6f26ahr 2069 1 In in IN cord-028721-x6f26ahr 2069 2 the the DT cord-028721-x6f26ahr 2069 3 initial initial JJ cord-028721-x6f26ahr 2069 4 stages stage NNS cord-028721-x6f26ahr 2069 5 of of IN cord-028721-x6f26ahr 2069 6 hyalinization hyalinization NN cord-028721-x6f26ahr 2069 7 associated associate VBN cord-028721-x6f26ahr 2069 8 with with IN cord-028721-x6f26ahr 2069 9 germ germ NN cord-028721-x6f26ahr 2069 10 cell cell NN cord-028721-x6f26ahr 2069 11 neoplasm neoplasm NN cord-028721-x6f26ahr 2069 12 , , , cord-028721-x6f26ahr 2069 13 the the DT cord-028721-x6f26ahr 2069 14 tubules tubule NNS cord-028721-x6f26ahr 2069 15 are be VBP cord-028721-x6f26ahr 2069 16 small small JJ cord-028721-x6f26ahr 2069 17 , , , cord-028721-x6f26ahr 2069 18 contain contain VBP cord-028721-x6f26ahr 2069 19 intratubular intratubular JJ cord-028721-x6f26ahr 2069 20 germ germ NN cord-028721-x6f26ahr 2069 21 cell cell NN cord-028721-x6f26ahr 2069 22 neoplasia neoplasia NN cord-028721-x6f26ahr 2069 23 and and CC cord-028721-x6f26ahr 2069 24 dedifferentiating dedifferentiate VBG cord-028721-x6f26ahr 2069 25 Sertoli Sertoli NNP cord-028721-x6f26ahr 2069 26 cells cell NNS cord-028721-x6f26ahr 2069 27 , , , cord-028721-x6f26ahr 2069 28 and and CC cord-028721-x6f26ahr 2069 29 the the DT cord-028721-x6f26ahr 2069 30 lamina lamina JJ cord-028721-x6f26ahr 2069 31 propria propria NNP cord-028721-x6f26ahr 2069 32 is be VBZ cord-028721-x6f26ahr 2069 33 infi infi NNP cord-028721-x6f26ahr 2069 34 ltrated ltrated NNP cord-028721-x6f26ahr 2069 35 by by IN cord-028721-x6f26ahr 2069 36 macrophages macrophage NNS cord-028721-x6f26ahr 2069 37 , , , cord-028721-x6f26ahr 2069 38 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 2069 39 , , , cord-028721-x6f26ahr 2069 40 and and CC cord-028721-x6f26ahr 2069 41 plasma plasma NN cord-028721-x6f26ahr 2069 42 cells cell NNS cord-028721-x6f26ahr 2069 43 . . . cord-028721-x6f26ahr 2070 1 In in IN cord-028721-x6f26ahr 2070 2 the the DT cord-028721-x6f26ahr 2070 3 fi fi NN cord-028721-x6f26ahr 2070 4 nal nal FW cord-028721-x6f26ahr 2070 5 stages stage NNS cord-028721-x6f26ahr 2070 6 , , , cord-028721-x6f26ahr 2070 7 the the DT cord-028721-x6f26ahr 2070 8 intratubular intratubular JJ cord-028721-x6f26ahr 2070 9 cells cell NNS cord-028721-x6f26ahr 2070 10 have have VBP cord-028721-x6f26ahr 2070 11 degenerated degenerate VBN cord-028721-x6f26ahr 2070 12 , , , cord-028721-x6f26ahr 2070 13 the the DT cord-028721-x6f26ahr 2070 14 infl infl NN cord-028721-x6f26ahr 2070 15 ammation ammation NNP cord-028721-x6f26ahr 2070 16 has have VBZ cord-028721-x6f26ahr 2070 17 disappeared disappear VBN cord-028721-x6f26ahr 2070 18 , , , cord-028721-x6f26ahr 2070 19 and and CC cord-028721-x6f26ahr 2070 20 the the DT cord-028721-x6f26ahr 2070 21 seminiferous seminiferous JJ cord-028721-x6f26ahr 2070 22 tubules tubule NNS cord-028721-x6f26ahr 2070 23 are be VBP cord-028721-x6f26ahr 2070 24 replaced replace VBN cord-028721-x6f26ahr 2070 25 by by IN cord-028721-x6f26ahr 2070 26 areas area NNS cord-028721-x6f26ahr 2070 27 of of IN cord-028721-x6f26ahr 2070 28 hypocellular hypocellular NN cord-028721-x6f26ahr 2070 29 or or CC cord-028721-x6f26ahr 2070 30 acellular acellular JJ cord-028721-x6f26ahr 2070 31 fi fi NN cord-028721-x6f26ahr 2070 32 brosis brosis NN cord-028721-x6f26ahr 2070 33 ( ( -LRB- cord-028721-x6f26ahr 2070 34 Fig Fig NNP cord-028721-x6f26ahr 2070 35 . . . cord-028721-x6f26ahr 2070 36 12 12 CD cord-028721-x6f26ahr 2070 37 - - SYM cord-028721-x6f26ahr 2070 38 95 95 CD cord-028721-x6f26ahr 2070 39 ) ) -RRB- cord-028721-x6f26ahr 2070 40 . . . cord-028721-x6f26ahr 2071 1 It -PRON- PRP cord-028721-x6f26ahr 2071 2 should should MD cord-028721-x6f26ahr 2071 3 be be VB cord-028721-x6f26ahr 2071 4 noted note VBN cord-028721-x6f26ahr 2071 5 that that IN cord-028721-x6f26ahr 2071 6 autoimmune autoimmune JJ cord-028721-x6f26ahr 2071 7 hyalinization hyalinization NN cord-028721-x6f26ahr 2071 8 is be VBZ cord-028721-x6f26ahr 2071 9 not not RB cord-028721-x6f26ahr 2071 10 the the DT cord-028721-x6f26ahr 2071 11 most most RBS cord-028721-x6f26ahr 2071 12 common common JJ cord-028721-x6f26ahr 2071 13 type type NN cord-028721-x6f26ahr 2071 14 of of IN cord-028721-x6f26ahr 2071 15 hyalinization hyalinization NN cord-028721-x6f26ahr 2071 16 associated associate VBN cord-028721-x6f26ahr 2071 17 with with IN cord-028721-x6f26ahr 2071 18 testicular testicular JJ cord-028721-x6f26ahr 2071 19 tumors tumor NNS cord-028721-x6f26ahr 2071 20 : : : cord-028721-x6f26ahr 2071 21 the the DT cord-028721-x6f26ahr 2071 22 obstructive obstructive JJ cord-028721-x6f26ahr 2071 23 , , , cord-028721-x6f26ahr 2071 24 ischemic ischemic JJ cord-028721-x6f26ahr 2071 25 , , , cord-028721-x6f26ahr 2071 26 and and CC cord-028721-x6f26ahr 2071 27 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2071 28 variants variant NNS cord-028721-x6f26ahr 2071 29 are be VBP cord-028721-x6f26ahr 2071 30 more more RBR cord-028721-x6f26ahr 2071 31 common common JJ cord-028721-x6f26ahr 2071 32 . . . cord-028721-x6f26ahr 2072 1 Radiation radiation NN cord-028721-x6f26ahr 2072 2 and and CC cord-028721-x6f26ahr 2072 3 a a DT cord-028721-x6f26ahr 2072 4 wide wide JJ cord-028721-x6f26ahr 2072 5 variety variety NN cord-028721-x6f26ahr 2072 6 of of IN cord-028721-x6f26ahr 2072 7 chemicals chemical NNS cord-028721-x6f26ahr 2072 8 cause cause VBP cord-028721-x6f26ahr 2072 9 tubular tubular JJ cord-028721-x6f26ahr 2072 10 hyalinization hyalinization NN cord-028721-x6f26ahr 2072 11 . . . cord-028721-x6f26ahr 2073 1 Lengthy lengthy JJ cord-028721-x6f26ahr 2073 2 cancer cancer NN cord-028721-x6f26ahr 2073 3 chemotherapy chemotherapy NN cord-028721-x6f26ahr 2073 4 combined combine VBN cord-028721-x6f26ahr 2073 5 with with IN cord-028721-x6f26ahr 2073 6 Infertility Infertility NNP cord-028721-x6f26ahr 2073 7 radiotherapy radiotherapy NN cord-028721-x6f26ahr 2073 8 invariably invariably RB cord-028721-x6f26ahr 2073 9 causes cause VBZ cord-028721-x6f26ahr 2073 10 hyalinization hyalinization NN cord-028721-x6f26ahr 2073 11 . . . cord-028721-x6f26ahr 2074 1 Children child NNS cord-028721-x6f26ahr 2074 2 's 's POS cord-028721-x6f26ahr 2074 3 testes testis NNS cord-028721-x6f26ahr 2074 4 are be VBP cord-028721-x6f26ahr 2074 5 more more RBR cord-028721-x6f26ahr 2074 6 sensitive sensitive JJ cord-028721-x6f26ahr 2074 7 to to IN cord-028721-x6f26ahr 2074 8 radiation radiation NN cord-028721-x6f26ahr 2074 9 than than IN cord-028721-x6f26ahr 2074 10 those those DT cord-028721-x6f26ahr 2074 11 of of IN cord-028721-x6f26ahr 2074 12 adults adult NNS cord-028721-x6f26ahr 2074 13 . . . cord-028721-x6f26ahr 2075 1 Radiation radiation NN cord-028721-x6f26ahr 2075 2 for for IN cord-028721-x6f26ahr 2075 3 testicular testicular JJ cord-028721-x6f26ahr 2075 4 leukemia leukemia NN cord-028721-x6f26ahr 2075 5 frequently frequently RB cord-028721-x6f26ahr 2075 6 causes cause VBZ cord-028721-x6f26ahr 2075 7 tubular tubular JJ cord-028721-x6f26ahr 2075 8 hyalinization hyalinization NN cord-028721-x6f26ahr 2075 9 . . . cord-028721-x6f26ahr 2076 1 In in IN cord-028721-x6f26ahr 2076 2 addition addition NN cord-028721-x6f26ahr 2076 3 , , , cord-028721-x6f26ahr 2076 4 radiation radiation NN cord-028721-x6f26ahr 2076 5 induces induce VBZ cord-028721-x6f26ahr 2076 6 dense dense JJ cord-028721-x6f26ahr 2076 7 interstitial interstitial JJ cord-028721-x6f26ahr 2076 8 fi fi NN cord-028721-x6f26ahr 2076 9 brosis brosis NN cord-028721-x6f26ahr 2076 10 and and CC cord-028721-x6f26ahr 2076 11 loss loss NN cord-028721-x6f26ahr 2076 12 of of IN cord-028721-x6f26ahr 2076 13 peritubular peritubular NNP cord-028721-x6f26ahr 2076 14 cells cell NNS cord-028721-x6f26ahr 2076 15 , , , cord-028721-x6f26ahr 2076 16 obscuring obscure VBG cord-028721-x6f26ahr 2076 17 the the DT cord-028721-x6f26ahr 2076 18 borders border NNS cord-028721-x6f26ahr 2076 19 between between IN cord-028721-x6f26ahr 2076 20 the the DT cord-028721-x6f26ahr 2076 21 interstitium interstitium NN cord-028721-x6f26ahr 2076 22 and and CC cord-028721-x6f26ahr 2076 23 the the DT cord-028721-x6f26ahr 2076 24 tubules tubule NNS cord-028721-x6f26ahr 2076 25 . . . cord-028721-x6f26ahr 2077 1 This this DT cord-028721-x6f26ahr 2077 2 makes make VBZ cord-028721-x6f26ahr 2077 3 the the DT cord-028721-x6f26ahr 2077 4 tubules tubule NNS cord-028721-x6f26ahr 2077 5 hard hard JJ cord-028721-x6f26ahr 2077 6 to to TO cord-028721-x6f26ahr 2077 7 see see VB cord-028721-x6f26ahr 2077 8 in in IN cord-028721-x6f26ahr 2077 9 hematoxylin hematoxylin JJ cord-028721-x6f26ahr 2077 10 - - HYPH cord-028721-x6f26ahr 2077 11 eosin eosin NN cord-028721-x6f26ahr 2077 12 - - HYPH cord-028721-x6f26ahr 2077 13 stained stain VBN cord-028721-x6f26ahr 2077 14 sections section NNS cord-028721-x6f26ahr 2077 15 . . . cord-028721-x6f26ahr 2078 1 Leydig leydig NN cord-028721-x6f26ahr 2078 2 cells cell NNS cord-028721-x6f26ahr 2078 3 are be VBP cord-028721-x6f26ahr 2078 4 atrophic atrophic JJ cord-028721-x6f26ahr 2078 5 and and CC cord-028721-x6f26ahr 2078 6 decreased decrease VBD cord-028721-x6f26ahr 2078 7 in in IN cord-028721-x6f26ahr 2078 8 number number NN cord-028721-x6f26ahr 2078 9 . . . cord-028721-x6f26ahr 2079 1 Ischemia ischemia NN cord-028721-x6f26ahr 2079 2 secondary secondary JJ cord-028721-x6f26ahr 2079 3 to to IN cord-028721-x6f26ahr 2079 4 radiation radiation NN cord-028721-x6f26ahr 2079 5 - - HYPH cord-028721-x6f26ahr 2079 6 induced induce VBN cord-028721-x6f26ahr 2079 7 vascular vascular JJ cord-028721-x6f26ahr 2079 8 injury injury NN cord-028721-x6f26ahr 2079 9 also also RB cord-028721-x6f26ahr 2079 10 contributes contribute VBZ cord-028721-x6f26ahr 2079 11 to to IN cord-028721-x6f26ahr 2079 12 hyalinization hyalinization NN cord-028721-x6f26ahr 2079 13 . . . cord-028721-x6f26ahr 2080 1 In in IN cord-028721-x6f26ahr 2080 2 tubular tubular JJ cord-028721-x6f26ahr 2080 3 hyalinization hyalinization NN cord-028721-x6f26ahr 2080 4 associated associate VBN cord-028721-x6f26ahr 2080 5 with with IN cord-028721-x6f26ahr 2080 6 cancer cancer NN cord-028721-x6f26ahr 2080 7 chemotherapy chemotherapy NN cord-028721-x6f26ahr 2080 8 , , , cord-028721-x6f26ahr 2080 9 in in IN cord-028721-x6f26ahr 2080 10 addition addition NN cord-028721-x6f26ahr 2080 11 to to IN cord-028721-x6f26ahr 2080 12 the the DT cord-028721-x6f26ahr 2080 13 direct direct JJ cord-028721-x6f26ahr 2080 14 toxicity toxicity NN cord-028721-x6f26ahr 2080 15 of of IN cord-028721-x6f26ahr 2080 16 drugs drug NNS cord-028721-x6f26ahr 2080 17 on on IN cord-028721-x6f26ahr 2080 18 seminiferous seminiferous JJ cord-028721-x6f26ahr 2080 19 tubular tubular JJ cord-028721-x6f26ahr 2080 20 cells cell NNS cord-028721-x6f26ahr 2080 21 ( ( -LRB- cord-028721-x6f26ahr 2080 22 see see VB cord-028721-x6f26ahr 2080 23 discussion discussion NN cord-028721-x6f26ahr 2080 24 on on IN cord-028721-x6f26ahr 2080 25 Sertoli sertoli JJ cord-028721-x6f26ahr 2080 26 cell cell NN cord-028721-x6f26ahr 2080 27 - - HYPH cord-028721-x6f26ahr 2080 28 only only JJ cord-028721-x6f26ahr 2080 29 syndrome syndrome NN cord-028721-x6f26ahr 2080 30 with with IN cord-028721-x6f26ahr 2080 31 involuting involute VBG cord-028721-x6f26ahr 2080 32 Sertoli Sertoli NNP cord-028721-x6f26ahr 2080 33 cells cell NNS cord-028721-x6f26ahr 2080 34 in in IN cord-028721-x6f26ahr 2080 35 this this DT cord-028721-x6f26ahr 2080 36 chapter chapter NN cord-028721-x6f26ahr 2080 37 ) ) -RRB- cord-028721-x6f26ahr 2080 38 , , , cord-028721-x6f26ahr 2080 39 nutritional nutritional JJ cord-028721-x6f26ahr 2080 40 defi defi NNP cord-028721-x6f26ahr 2080 41 ciencies ciencies NNP cord-028721-x6f26ahr 2080 42 cause cause IN cord-028721-x6f26ahr 2080 43 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2080 44 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2080 45 . . . cord-028721-x6f26ahr 2081 1 922 922 CD cord-028721-x6f26ahr 2081 2 , , , cord-028721-x6f26ahr 2081 3 923 923 CD cord-028721-x6f26ahr 2081 4 _SP cord-028721-x6f26ahr 2082 1 Histophysiological Histophysiological NNP cord-028721-x6f26ahr 2082 2 studies study NNS cord-028721-x6f26ahr 2082 3 have have VBP cord-028721-x6f26ahr 2082 4 distinguished distinguish VBN cord-028721-x6f26ahr 2082 5 two two CD cord-028721-x6f26ahr 2082 6 compartments compartment NNS cord-028721-x6f26ahr 2082 7 in in IN cord-028721-x6f26ahr 2082 8 the the DT cord-028721-x6f26ahr 2082 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 2082 10 tubules tubule NNS cord-028721-x6f26ahr 2082 11 : : : cord-028721-x6f26ahr 2082 12 basal basal NN cord-028721-x6f26ahr 2082 13 and and CC cord-028721-x6f26ahr 2082 14 adluminal adluminal NNP cord-028721-x6f26ahr 2082 15 . . . cord-028721-x6f26ahr 2083 1 The the DT cord-028721-x6f26ahr 2083 2 blood blood NN cord-028721-x6f26ahr 2083 3 - - HYPH cord-028721-x6f26ahr 2083 4 testis testis NN cord-028721-x6f26ahr 2083 5 barrier barrier NN cord-028721-x6f26ahr 2083 6 separates separate VBZ cord-028721-x6f26ahr 2083 7 these these DT cord-028721-x6f26ahr 2083 8 , , , cord-028721-x6f26ahr 2083 9 and and CC cord-028721-x6f26ahr 2083 10 each each DT cord-028721-x6f26ahr 2083 11 contains contain VBZ cord-028721-x6f26ahr 2083 12 different different JJ cord-028721-x6f26ahr 2083 13 cell cell NN cord-028721-x6f26ahr 2083 14 types type NNS cord-028721-x6f26ahr 2083 15 with with IN cord-028721-x6f26ahr 2083 16 diverse diverse JJ cord-028721-x6f26ahr 2083 17 hormonal hormonal JJ cord-028721-x6f26ahr 2083 18 and and CC cord-028721-x6f26ahr 2083 19 nutritional nutritional JJ cord-028721-x6f26ahr 2083 20 requirements requirement NNS cord-028721-x6f26ahr 2083 21 . . . cord-028721-x6f26ahr 2084 1 On on IN cord-028721-x6f26ahr 2084 2 this this DT cord-028721-x6f26ahr 2084 3 basis basis NN cord-028721-x6f26ahr 2084 4 , , , cord-028721-x6f26ahr 2084 5 lesions lesion NNS cord-028721-x6f26ahr 2084 6 may may MD cord-028721-x6f26ahr 2084 7 be be VB cord-028721-x6f26ahr 2084 8 classifi classifi NNP cord-028721-x6f26ahr 2084 9 ed ed NN cord-028721-x6f26ahr 2084 10 as as IN cord-028721-x6f26ahr 2084 11 involving involve VBG cord-028721-x6f26ahr 2084 12 only only RB cord-028721-x6f26ahr 2084 13 the the DT cord-028721-x6f26ahr 2084 14 adluminal adluminal NNP cord-028721-x6f26ahr 2084 15 compartment compartment NNP cord-028721-x6f26ahr 2084 16 or or CC cord-028721-x6f26ahr 2084 17 both both CC cord-028721-x6f26ahr 2084 18 the the DT cord-028721-x6f26ahr 2084 19 basal basal NN cord-028721-x6f26ahr 2084 20 and and CC cord-028721-x6f26ahr 2084 21 the the DT cord-028721-x6f26ahr 2084 22 adluminal adluminal NNP cord-028721-x6f26ahr 2084 23 compartments compartment NNS cord-028721-x6f26ahr 2084 24 . . . cord-028721-x6f26ahr 2085 1 The the DT cord-028721-x6f26ahr 2085 2 following follow VBG cord-028721-x6f26ahr 2085 3 discussion discussion NN cord-028721-x6f26ahr 2085 4 of of IN cord-028721-x6f26ahr 2085 5 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 2085 6 lesions lesion NNS cord-028721-x6f26ahr 2085 7 uses use VBZ cord-028721-x6f26ahr 2085 8 this this DT cord-028721-x6f26ahr 2085 9 new new JJ cord-028721-x6f26ahr 2085 10 concept concept NN cord-028721-x6f26ahr 2085 11 of of IN cord-028721-x6f26ahr 2085 12 tubular tubular JJ cord-028721-x6f26ahr 2085 13 pathophysiology pathophysiology NN cord-028721-x6f26ahr 2085 14 , , , cord-028721-x6f26ahr 2085 15 conserving conserve VBG cord-028721-x6f26ahr 2085 16 as as RB cord-028721-x6f26ahr 2085 17 much much RB cord-028721-x6f26ahr 2085 18 as as IN cord-028721-x6f26ahr 2085 19 possible possible JJ cord-028721-x6f26ahr 2085 20 of of IN cord-028721-x6f26ahr 2085 21 the the DT cord-028721-x6f26ahr 2085 22 classic classic JJ cord-028721-x6f26ahr 2085 23 terminology terminology NN cord-028721-x6f26ahr 2085 24 . . . cord-028721-x6f26ahr 2086 1 This this DT cord-028721-x6f26ahr 2086 2 category category NN cord-028721-x6f26ahr 2086 3 includes include VBZ cord-028721-x6f26ahr 2086 4 all all DT cord-028721-x6f26ahr 2086 5 infertile infertile JJ cord-028721-x6f26ahr 2086 6 testes testis NNS cord-028721-x6f26ahr 2086 7 with with IN cord-028721-x6f26ahr 2086 8 normal normal JJ cord-028721-x6f26ahr 2086 9 numbers number NNS cord-028721-x6f26ahr 2086 10 of of IN cord-028721-x6f26ahr 2086 11 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2086 12 per per IN cord-028721-x6f26ahr 2086 13 cross cross JJ cord-028721-x6f26ahr 2086 14 - - JJ cord-028721-x6f26ahr 2086 15 sectioned sectioned JJ cord-028721-x6f26ahr 2086 16 tubule tubule NN cord-028721-x6f26ahr 2086 17 , , , cord-028721-x6f26ahr 2086 18 normal normal JJ cord-028721-x6f26ahr 2086 19 or or CC cord-028721-x6f26ahr 2086 20 decreased decrease VBD cord-028721-x6f26ahr 2086 21 numbers number NNS cord-028721-x6f26ahr 2086 22 of of IN cord-028721-x6f26ahr 2086 23 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2086 24 and and CC cord-028721-x6f26ahr 2086 25 young young JJ cord-028721-x6f26ahr 2086 26 spermatids spermatid NNS cord-028721-x6f26ahr 2086 27 , , , cord-028721-x6f26ahr 2086 28 and and CC cord-028721-x6f26ahr 2086 29 variable variable JJ cord-028721-x6f26ahr 2086 30 numbers number NNS cord-028721-x6f26ahr 2086 31 of of IN cord-028721-x6f26ahr 2086 32 adult adult NN cord-028721-x6f26ahr 2086 33 spermatids spermatid NNS cord-028721-x6f26ahr 2086 34 . . . cord-028721-x6f26ahr 2087 1 A a DT cord-028721-x6f26ahr 2087 2 descriptive descriptive JJ cord-028721-x6f26ahr 2087 3 term term NN cord-028721-x6f26ahr 2087 4 for for IN cord-028721-x6f26ahr 2087 5 this this DT cord-028721-x6f26ahr 2087 6 disorder disorder NN cord-028721-x6f26ahr 2087 7 is be VBZ cord-028721-x6f26ahr 2087 8 immature immature JJ cord-028721-x6f26ahr 2087 9 germ germ NN cord-028721-x6f26ahr 2087 10 cell cell NN cord-028721-x6f26ahr 2087 11 sloughing slough VBG cord-028721-x6f26ahr 2087 12 . . . cord-028721-x6f26ahr 2088 1 A a DT cord-028721-x6f26ahr 2088 2 few few JJ cord-028721-x6f26ahr 2088 3 immature immature JJ cord-028721-x6f26ahr 2088 4 germ germ NN cord-028721-x6f26ahr 2088 5 cells cell NNS cord-028721-x6f26ahr 2088 6 are be VBP cord-028721-x6f26ahr 2088 7 normally normally RB cord-028721-x6f26ahr 2088 8 found find VBN cord-028721-x6f26ahr 2088 9 in in IN cord-028721-x6f26ahr 2088 10 the the DT cord-028721-x6f26ahr 2088 11 lumina lumina NNP cord-028721-x6f26ahr 2088 12 of of IN cord-028721-x6f26ahr 2088 13 the the DT cord-028721-x6f26ahr 2088 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 2088 15 tubules tubule NNS cord-028721-x6f26ahr 2088 16 , , , cord-028721-x6f26ahr 2088 17 923 923 CD cord-028721-x6f26ahr 2088 18 a a DT cord-028721-x6f26ahr 2088 19 fi fi NN cord-028721-x6f26ahr 2088 20 nding nding NN cord-028721-x6f26ahr 2088 21 that that WDT cord-028721-x6f26ahr 2088 22 correlates correlate VBZ cord-028721-x6f26ahr 2088 23 with with IN cord-028721-x6f26ahr 2088 24 their -PRON- PRP$ cord-028721-x6f26ahr 2088 25 presence presence NN cord-028721-x6f26ahr 2088 26 in in IN cord-028721-x6f26ahr 2088 27 the the DT cord-028721-x6f26ahr 2088 28 ejaculates ejaculate NNS cord-028721-x6f26ahr 2088 29 of of IN cord-028721-x6f26ahr 2088 30 fertile fertile JJ cord-028721-x6f26ahr 2088 31 men man NNS cord-028721-x6f26ahr 2088 32 . . . cord-028721-x6f26ahr 2089 1 924 924 CD cord-028721-x6f26ahr 2090 1 When when WRB cord-028721-x6f26ahr 2090 2 these these DT cord-028721-x6f26ahr 2090 3 cells cell NNS cord-028721-x6f26ahr 2090 4 make make VBP cord-028721-x6f26ahr 2090 5 up up RP cord-028721-x6f26ahr 2090 6 more more JJR cord-028721-x6f26ahr 2090 7 than than IN cord-028721-x6f26ahr 2090 8 4 4 CD cord-028721-x6f26ahr 2090 9 % % NN cord-028721-x6f26ahr 2090 10 of of IN cord-028721-x6f26ahr 2090 11 the the DT cord-028721-x6f26ahr 2090 12 cells cell NNS cord-028721-x6f26ahr 2090 13 in in IN cord-028721-x6f26ahr 2090 14 the the DT cord-028721-x6f26ahr 2090 15 ejaculate ejaculate NN cord-028721-x6f26ahr 2090 16 , , , cord-028721-x6f26ahr 2090 17 it -PRON- PRP cord-028721-x6f26ahr 2090 18 is be VBZ cord-028721-x6f26ahr 2090 19 abnormal abnormal JJ cord-028721-x6f26ahr 2090 20 and and CC cord-028721-x6f26ahr 2090 21 the the DT cord-028721-x6f26ahr 2090 22 result result NN cord-028721-x6f26ahr 2090 23 of of IN cord-028721-x6f26ahr 2090 24 premature premature JJ cord-028721-x6f26ahr 2090 25 sloughing sloughing NN cord-028721-x6f26ahr 2090 26 of of IN cord-028721-x6f26ahr 2090 27 spermatids spermatid NNS cord-028721-x6f26ahr 2090 28 and and CC cord-028721-x6f26ahr 2090 29 , , , cord-028721-x6f26ahr 2090 30 in in IN cord-028721-x6f26ahr 2090 31 some some DT cord-028721-x6f26ahr 2090 32 cases case NNS cord-028721-x6f26ahr 2090 33 , , , cord-028721-x6f26ahr 2090 34 of of IN cord-028721-x6f26ahr 2090 35 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2090 36 . . . cord-028721-x6f26ahr 2091 1 925 925 CD cord-028721-x6f26ahr 2091 2 , , , cord-028721-x6f26ahr 2091 3 926 926 CD cord-028721-x6f26ahr 2092 1 Some some DT cord-028721-x6f26ahr 2092 2 authors author NNS cord-028721-x6f26ahr 2092 3 have have VBP cord-028721-x6f26ahr 2092 4 attempted attempt VBN cord-028721-x6f26ahr 2092 5 to to TO cord-028721-x6f26ahr 2092 6 establish establish VB cord-028721-x6f26ahr 2092 7 a a DT cord-028721-x6f26ahr 2092 8 correlation correlation NN cord-028721-x6f26ahr 2092 9 between between IN cord-028721-x6f26ahr 2092 10 the the DT cord-028721-x6f26ahr 2092 11 number number NN cord-028721-x6f26ahr 2092 12 of of IN cord-028721-x6f26ahr 2092 13 sloughed slough VBN cord-028721-x6f26ahr 2092 14 immature immature JJ cord-028721-x6f26ahr 2092 15 germ germ NN cord-028721-x6f26ahr 2092 16 cells cell NNS cord-028721-x6f26ahr 2092 17 and and CC cord-028721-x6f26ahr 2092 18 the the DT cord-028721-x6f26ahr 2092 19 severity severity NN cord-028721-x6f26ahr 2092 20 of of IN cord-028721-x6f26ahr 2092 21 lesions lesion NNS cord-028721-x6f26ahr 2092 22 of of IN cord-028721-x6f26ahr 2092 23 the the DT cord-028721-x6f26ahr 2092 24 seminiferous seminiferous JJ cord-028721-x6f26ahr 2092 25 tubules tubule NNS cord-028721-x6f26ahr 2092 26 using use VBG cord-028721-x6f26ahr 2092 27 light light JJ cord-028721-x6f26ahr 2092 28 927 927 CD cord-028721-x6f26ahr 2092 29 and and CC cord-028721-x6f26ahr 2092 30 electron electron NN cord-028721-x6f26ahr 2092 31 928 928 CD cord-028721-x6f26ahr 2092 32 microscopy microscopy NN cord-028721-x6f26ahr 2092 33 . . . cord-028721-x6f26ahr 2093 1 Lesions lesion NNS cord-028721-x6f26ahr 2093 2 in in IN cord-028721-x6f26ahr 2093 3 the the DT cord-028721-x6f26ahr 2093 4 adluminal adluminal NNP cord-028721-x6f26ahr 2093 5 compartment compartment NNP cord-028721-x6f26ahr 2093 6 are be VBP cord-028721-x6f26ahr 2093 7 classifi classifi NNP cord-028721-x6f26ahr 2093 8 ed ed NNP cord-028721-x6f26ahr 2094 1 according accord VBG cord-028721-x6f26ahr 2094 2 to to IN cord-028721-x6f26ahr 2094 3 the the DT cord-028721-x6f26ahr 2094 4 most most RBS cord-028721-x6f26ahr 2094 5 abundant abundant JJ cord-028721-x6f26ahr 2094 6 type type NN cord-028721-x6f26ahr 2094 7 of of IN cord-028721-x6f26ahr 2094 8 germ germ NN cord-028721-x6f26ahr 2094 9 cell cell NN cord-028721-x6f26ahr 2094 10 whose whose WP$ cord-028721-x6f26ahr 2094 11 maturation maturation NN cord-028721-x6f26ahr 2094 12 is be VBZ cord-028721-x6f26ahr 2094 13 arrested arrest VBN cord-028721-x6f26ahr 2094 14 and and CC cord-028721-x6f26ahr 2094 15 which which WDT cord-028721-x6f26ahr 2094 16 then then RB cord-028721-x6f26ahr 2094 17 sloughs slough VBZ cord-028721-x6f26ahr 2094 18 : : : cord-028721-x6f26ahr 2094 19 young young JJ cord-028721-x6f26ahr 2094 20 spermatids spermatid NNS cord-028721-x6f26ahr 2094 21 , , , cord-028721-x6f26ahr 2094 22 late late JJ cord-028721-x6f26ahr 2094 23 primary primary JJ cord-028721-x6f26ahr 2094 24 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2094 25 , , , cord-028721-x6f26ahr 2094 26 or or CC cord-028721-x6f26ahr 2094 27 early early JJ cord-028721-x6f26ahr 2094 28 primary primary JJ cord-028721-x6f26ahr 2094 29 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2094 30 ( ( -LRB- cord-028721-x6f26ahr 2094 31 Fig Fig NNP cord-028721-x6f26ahr 2094 32 . . . cord-028721-x6f26ahr 2094 33 12 12 CD cord-028721-x6f26ahr 2094 34 - - SYM cord-028721-x6f26ahr 2094 35 96 96 CD cord-028721-x6f26ahr 2094 36 ) ) -RRB- cord-028721-x6f26ahr 2094 37 . . . cord-028721-x6f26ahr 2095 1 Young young JJ cord-028721-x6f26ahr 2095 2 spermatid spermatid NN cord-028721-x6f26ahr 2095 3 sloughing slough VBG cord-028721-x6f26ahr 2095 4 Young young JJ cord-028721-x6f26ahr 2095 5 spermatid spermatid JJ cord-028721-x6f26ahr 2095 6 sloughing sloughing NN cord-028721-x6f26ahr 2095 7 is be VBZ cord-028721-x6f26ahr 2095 8 present present JJ cord-028721-x6f26ahr 2095 9 when when WRB cord-028721-x6f26ahr 2095 10 the the DT cord-028721-x6f26ahr 2095 11 ratio ratio NN cord-028721-x6f26ahr 2095 12 of of IN cord-028721-x6f26ahr 2095 13 elongated elongated JJ cord-028721-x6f26ahr 2095 14 ( ( -LRB- cord-028721-x6f26ahr 2095 15 S s NN cord-028721-x6f26ahr 2095 16 c c NN cord-028721-x6f26ahr 2095 17 + + CC cord-028721-x6f26ahr 2095 18 S s NN cord-028721-x6f26ahr 2095 19 d d NN cord-028721-x6f26ahr 2095 20 ) ) -RRB- cord-028721-x6f26ahr 2095 21 spermatids spermatid NNS cord-028721-x6f26ahr 2095 22 to to TO cord-028721-x6f26ahr 2095 23 round round VB cord-028721-x6f26ahr 2095 24 ( ( -LRB- cord-028721-x6f26ahr 2095 25 S S NNP cord-028721-x6f26ahr 2095 26 a a DT cord-028721-x6f26ahr 2095 27 + + CC cord-028721-x6f26ahr 2095 28 S s NN cord-028721-x6f26ahr 2095 29 b b NN cord-028721-x6f26ahr 2095 30 ) ) -RRB- cord-028721-x6f26ahr 2095 31 spermatids spermatids NNP cord-028721-x6f26ahr 2095 32 is be VBZ cord-028721-x6f26ahr 2095 33 lower low JJR cord-028721-x6f26ahr 2095 34 than than IN cord-028721-x6f26ahr 2095 35 normal normal JJ cord-028721-x6f26ahr 2095 36 . . . cord-028721-x6f26ahr 2096 1 The the DT cord-028721-x6f26ahr 2096 2 implication implication NN cord-028721-x6f26ahr 2096 3 of of IN cord-028721-x6f26ahr 2096 4 this this DT cord-028721-x6f26ahr 2096 5 pattern pattern NN cord-028721-x6f26ahr 2096 6 is be VBZ cord-028721-x6f26ahr 2096 7 that that IN cord-028721-x6f26ahr 2096 8 many many JJ cord-028721-x6f26ahr 2096 9 round round JJ cord-028721-x6f26ahr 2096 10 spermatids spermatid NNS cord-028721-x6f26ahr 2096 11 are be VBP cord-028721-x6f26ahr 2096 12 incapable incapable JJ cord-028721-x6f26ahr 2096 13 of of IN cord-028721-x6f26ahr 2096 14 further further JJ cord-028721-x6f26ahr 2096 15 differentiation differentiation NN cord-028721-x6f26ahr 2096 16 and and CC cord-028721-x6f26ahr 2096 17 are be VBP cord-028721-x6f26ahr 2096 18 sloughed slough VBN cord-028721-x6f26ahr 2096 19 ( ( -LRB- cord-028721-x6f26ahr 2096 20 Fig Fig NNP cord-028721-x6f26ahr 2096 21 . . . cord-028721-x6f26ahr 2096 22 _SP cord-028721-x6f26ahr 2096 23 12 12 CD cord-028721-x6f26ahr 2096 24 - - SYM cord-028721-x6f26ahr 2096 25 97 97 CD cord-028721-x6f26ahr 2096 26 ) ) -RRB- cord-028721-x6f26ahr 2096 27 . . . cord-028721-x6f26ahr 2097 1 Late late JJ cord-028721-x6f26ahr 2097 2 primary primary JJ cord-028721-x6f26ahr 2097 3 spermatocyte spermatocyte NN cord-028721-x6f26ahr 2097 4 sloughing slough VBG cord-028721-x6f26ahr 2097 5 In in IN cord-028721-x6f26ahr 2097 6 this this DT cord-028721-x6f26ahr 2097 7 condition condition NN cord-028721-x6f26ahr 2097 8 , , , cord-028721-x6f26ahr 2097 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2097 10 develops develop VBZ cord-028721-x6f26ahr 2097 11 normally normally RB cord-028721-x6f26ahr 2097 12 up up IN cord-028721-x6f26ahr 2097 13 to to IN cord-028721-x6f26ahr 2097 14 the the DT cord-028721-x6f26ahr 2097 15 level level NN cord-028721-x6f26ahr 2097 16 of of IN cord-028721-x6f26ahr 2097 17 interphase interphase NN cord-028721-x6f26ahr 2097 18 primary primary JJ cord-028721-x6f26ahr 2097 19 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2097 20 , , , cord-028721-x6f26ahr 2097 21 and and CC cord-028721-x6f26ahr 2097 22 these these DT cord-028721-x6f26ahr 2097 23 are be VBP cord-028721-x6f26ahr 2097 24 present present JJ cord-028721-x6f26ahr 2097 25 in in IN cord-028721-x6f26ahr 2097 26 normal normal JJ cord-028721-x6f26ahr 2097 27 numbers number NNS cord-028721-x6f26ahr 2097 28 . . . cord-028721-x6f26ahr 2098 1 Afterwards afterwards RB cord-028721-x6f26ahr 2098 2 , , , cord-028721-x6f26ahr 2098 3 these these DT cord-028721-x6f26ahr 2098 4 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2098 5 degenerate degenerate VBP cord-028721-x6f26ahr 2098 6 without without IN cord-028721-x6f26ahr 2098 7 achieving achieve VBG cord-028721-x6f26ahr 2098 8 meiosis meiosis NN cord-028721-x6f26ahr 2098 9 and and CC cord-028721-x6f26ahr 2098 10 slough slough VB cord-028721-x6f26ahr 2098 11 into into IN cord-028721-x6f26ahr 2098 12 the the DT cord-028721-x6f26ahr 2098 13 tubular tubular JJ cord-028721-x6f26ahr 2098 14 lumen lumen NN cord-028721-x6f26ahr 2098 15 . . . cord-028721-x6f26ahr 2099 1 All all DT cord-028721-x6f26ahr 2099 2 types type NNS cord-028721-x6f26ahr 2099 3 of of IN cord-028721-x6f26ahr 2099 4 spermatid spermatid NNP cord-028721-x6f26ahr 2099 5 are be VBP cord-028721-x6f26ahr 2099 6 greatly greatly RB cord-028721-x6f26ahr 2099 7 reduced reduce VBN cord-028721-x6f26ahr 2099 8 in in IN cord-028721-x6f26ahr 2099 9 number number NN cord-028721-x6f26ahr 2099 10 . . . cord-028721-x6f26ahr 2100 1 When when WRB cord-028721-x6f26ahr 2100 2 biopsies biopsy NNS cord-028721-x6f26ahr 2100 3 of of IN cord-028721-x6f26ahr 2100 4 these these DT cord-028721-x6f26ahr 2100 5 testes testis NNS cord-028721-x6f26ahr 2100 6 are be VBP cord-028721-x6f26ahr 2100 7 not not RB cord-028721-x6f26ahr 2100 8 properly properly RB cord-028721-x6f26ahr 2100 9 fi fi FW cord-028721-x6f26ahr 2100 10 xed xed FW cord-028721-x6f26ahr 2100 11 , , , cord-028721-x6f26ahr 2100 12 the the DT cord-028721-x6f26ahr 2100 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2100 14 tubules tubule NNS cord-028721-x6f26ahr 2100 15 may may MD cord-028721-x6f26ahr 2100 16 have have VB cord-028721-x6f26ahr 2100 17 a a DT cord-028721-x6f26ahr 2100 18 target target NN cord-028721-x6f26ahr 2100 19 - - HYPH cord-028721-x6f26ahr 2100 20 like like JJ cord-028721-x6f26ahr 2100 21 appearance appearance NN cord-028721-x6f26ahr 2100 22 , , , cord-028721-x6f26ahr 2100 23 with with IN cord-028721-x6f26ahr 2100 24 numerous numerous JJ cord-028721-x6f26ahr 2100 25 cells cell NNS cord-028721-x6f26ahr 2100 26 in in IN cord-028721-x6f26ahr 2100 27 the the DT cord-028721-x6f26ahr 2100 28 lumen lumen NN cord-028721-x6f26ahr 2100 29 . . . cord-028721-x6f26ahr 2101 1 This this DT cord-028721-x6f26ahr 2101 2 appearance appearance NN cord-028721-x6f26ahr 2101 3 sometimes sometimes RB cord-028721-x6f26ahr 2101 4 has have VBZ cord-028721-x6f26ahr 2101 5 been be VBN cord-028721-x6f26ahr 2101 6 referred refer VBN cord-028721-x6f26ahr 2101 7 to to IN cord-028721-x6f26ahr 2101 8 as as RB cord-028721-x6f26ahr 2101 9 tubular tubular JJ cord-028721-x6f26ahr 2101 10 blockage blockage NN cord-028721-x6f26ahr 2101 11 . . . cord-028721-x6f26ahr 2102 1 Another another DT cord-028721-x6f26ahr 2102 2 descriptive descriptive JJ cord-028721-x6f26ahr 2102 3 term term NN cord-028721-x6f26ahr 2102 4 , , , cord-028721-x6f26ahr 2102 5 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 2102 6 arrest arrest NN cord-028721-x6f26ahr 2102 7 , , , cord-028721-x6f26ahr 2102 8 also also RB cord-028721-x6f26ahr 2102 9 has have VBZ cord-028721-x6f26ahr 2102 10 been be VBN cord-028721-x6f26ahr 2102 11 applied apply VBN cord-028721-x6f26ahr 2102 12 to to IN cord-028721-x6f26ahr 2102 13 this this DT cord-028721-x6f26ahr 2102 14 morphology morphology NN cord-028721-x6f26ahr 2102 15 . . . cord-028721-x6f26ahr 2103 1 The the DT cord-028721-x6f26ahr 2103 2 latter latter JJ cord-028721-x6f26ahr 2103 3 term term NN cord-028721-x6f26ahr 2103 4 is be VBZ cord-028721-x6f26ahr 2103 5 inadequate inadequate JJ cord-028721-x6f26ahr 2103 6 in in IN cord-028721-x6f26ahr 2103 7 most most JJS cord-028721-x6f26ahr 2103 8 cases case NNS cord-028721-x6f26ahr 2103 9 , , , cord-028721-x6f26ahr 2103 10 because because IN cord-028721-x6f26ahr 2103 11 some some DT cord-028721-x6f26ahr 2103 12 spermatids spermatid NNS cord-028721-x6f26ahr 2103 13 are be VBP cord-028721-x6f26ahr 2103 14 present present JJ cord-028721-x6f26ahr 2103 15 , , , cord-028721-x6f26ahr 2103 16 and and CC cord-028721-x6f26ahr 2103 17 the the DT cord-028721-x6f26ahr 2103 18 number number NN cord-028721-x6f26ahr 2103 19 of of IN cord-028721-x6f26ahr 2103 20 primary primary JJ cord-028721-x6f26ahr 2103 21 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2103 22 is be VBZ cord-028721-x6f26ahr 2103 23 usually usually RB cord-028721-x6f26ahr 2103 24 not not RB cord-028721-x6f26ahr 2103 25 increased increase VBN cord-028721-x6f26ahr 2103 26 as as IN cord-028721-x6f26ahr 2103 27 would would MD cord-028721-x6f26ahr 2103 28 occur occur VB cord-028721-x6f26ahr 2103 29 if if IN cord-028721-x6f26ahr 2103 30 the the DT cord-028721-x6f26ahr 2103 31 transformation transformation NN cord-028721-x6f26ahr 2103 32 of of IN cord-028721-x6f26ahr 2103 33 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2103 34 into into IN cord-028721-x6f26ahr 2103 35 spermatid spermatid NNP cord-028721-x6f26ahr 2103 36 were be VBD cord-028721-x6f26ahr 2103 37 blocked block VBN cord-028721-x6f26ahr 2103 38 ( ( -LRB- cord-028721-x6f26ahr 2103 39 Fig Fig NNP cord-028721-x6f26ahr 2103 40 . . . cord-028721-x6f26ahr 2103 41 12 12 CD cord-028721-x6f26ahr 2103 42 - - SYM cord-028721-x6f26ahr 2103 43 98 98 CD cord-028721-x6f26ahr 2103 44 ) ) -RRB- cord-028721-x6f26ahr 2103 45 . . . cord-028721-x6f26ahr 2104 1 Late late JJ cord-028721-x6f26ahr 2104 2 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 2104 3 sloughing sloughing NN cord-028721-x6f26ahr 2104 4 is be VBZ cord-028721-x6f26ahr 2104 5 a a DT cord-028721-x6f26ahr 2104 6 more more RBR cord-028721-x6f26ahr 2104 7 accurate accurate JJ cord-028721-x6f26ahr 2104 8 term term NN cord-028721-x6f26ahr 2104 9 for for IN cord-028721-x6f26ahr 2104 10 this this DT cord-028721-x6f26ahr 2104 11 condition condition NN cord-028721-x6f26ahr 2104 12 and and CC cord-028721-x6f26ahr 2104 13 is be VBZ cord-028721-x6f26ahr 2104 14 preferred prefer VBN cord-028721-x6f26ahr 2104 15 . . . cord-028721-x6f26ahr 2105 1 Primary primary JJ cord-028721-x6f26ahr 2105 2 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 2105 3 sloughing sloughing NN cord-028721-x6f26ahr 2105 4 occurs occur VBZ cord-028721-x6f26ahr 2105 5 at at IN cord-028721-x6f26ahr 2105 6 the the DT cord-028721-x6f26ahr 2105 7 pachytene pachytene NNP cord-028721-x6f26ahr 2105 8 or or CC cord-028721-x6f26ahr 2105 9 diplotene diplotene JJ cord-028721-x6f26ahr 2105 10 stage stage NN cord-028721-x6f26ahr 2105 11 of of IN cord-028721-x6f26ahr 2105 12 meiosis meiosis NN cord-028721-x6f26ahr 2105 13 . . . cord-028721-x6f26ahr 2106 1 Early early JJ cord-028721-x6f26ahr 2106 2 primary primary JJ cord-028721-x6f26ahr 2106 3 spermatocyte spermatocyte NN cord-028721-x6f26ahr 2106 4 sloughing slough VBG cord-028721-x6f26ahr 2106 5 This this DT cord-028721-x6f26ahr 2106 6 lesion lesion NN cord-028721-x6f26ahr 2106 7 is be VBZ cord-028721-x6f26ahr 2106 8 characterized characterize VBN cord-028721-x6f26ahr 2106 9 by by IN cord-028721-x6f26ahr 2106 10 the the DT cord-028721-x6f26ahr 2106 11 presence presence NN cord-028721-x6f26ahr 2106 12 of of IN cord-028721-x6f26ahr 2106 13 a a DT cord-028721-x6f26ahr 2106 14 normal normal JJ cord-028721-x6f26ahr 2106 15 number number NN cord-028721-x6f26ahr 2106 16 of of IN cord-028721-x6f26ahr 2106 17 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2106 18 and and CC cord-028721-x6f26ahr 2106 19 decreased decrease VBD cord-028721-x6f26ahr 2106 20 numbers number NNS cord-028721-x6f26ahr 2106 21 of of IN cord-028721-x6f26ahr 2106 22 primary primary JJ cord-028721-x6f26ahr 2106 23 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2106 24 ( ( -LRB- cord-028721-x6f26ahr 2106 25 Fig Fig NNP cord-028721-x6f26ahr 2106 26 . . . cord-028721-x6f26ahr 2106 27 12 12 CD cord-028721-x6f26ahr 2106 28 - - SYM cord-028721-x6f26ahr 2106 29 99 99 CD cord-028721-x6f26ahr 2106 30 ) ) -RRB- cord-028721-x6f26ahr 2106 31 . . . cord-028721-x6f26ahr 2107 1 The the DT cord-028721-x6f26ahr 2107 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 2107 3 tubules tubule NNS cord-028721-x6f26ahr 2107 4 may may MD cord-028721-x6f26ahr 2107 5 contain contain VB cord-028721-x6f26ahr 2107 6 a a DT cord-028721-x6f26ahr 2107 7 few few JJ cord-028721-x6f26ahr 2107 8 spermatids spermatid NNS cord-028721-x6f26ahr 2107 9 . . . cord-028721-x6f26ahr 2108 1 The the DT cord-028721-x6f26ahr 2108 2 term term NN cord-028721-x6f26ahr 2108 3 early early JJ cord-028721-x6f26ahr 2108 4 primary primary JJ cord-028721-x6f26ahr 2108 5 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2108 6 sloughing sloughing NN cord-028721-x6f26ahr 2108 7 does do VBZ cord-028721-x6f26ahr 2108 8 not not RB cord-028721-x6f26ahr 2108 9 necessarily necessarily RB cord-028721-x6f26ahr 2108 10 imply imply VB cord-028721-x6f26ahr 2108 11 an an DT cord-028721-x6f26ahr 2108 12 early early JJ cord-028721-x6f26ahr 2108 13 meiotic meiotic JJ cord-028721-x6f26ahr 2108 14 lesion lesion NN cord-028721-x6f26ahr 2108 15 , , , cord-028721-x6f26ahr 2108 16 which which WDT cord-028721-x6f26ahr 2108 17 is be VBZ cord-028721-x6f26ahr 2108 18 quite quite RB cord-028721-x6f26ahr 2108 19 rare rare JJ cord-028721-x6f26ahr 2108 20 . . . cord-028721-x6f26ahr 2109 1 856 856 CD cord-028721-x6f26ahr 2109 2 , , , cord-028721-x6f26ahr 2110 1 926 926 CD cord-028721-x6f26ahr 2111 1 Rather rather RB cord-028721-x6f26ahr 2111 2 , , , cord-028721-x6f26ahr 2111 3 it -PRON- PRP cord-028721-x6f26ahr 2111 4 refers refer VBZ cord-028721-x6f26ahr 2111 5 to to IN cord-028721-x6f26ahr 2111 6 the the DT cord-028721-x6f26ahr 2111 7 sloughing sloughing NN cord-028721-x6f26ahr 2111 8 of of IN cord-028721-x6f26ahr 2111 9 newly newly RB cord-028721-x6f26ahr 2111 10 formed form VBN cord-028721-x6f26ahr 2111 11 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2111 12 . . . cord-028721-x6f26ahr 2112 1 The the DT cord-028721-x6f26ahr 2112 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 2112 3 cells cell NNS cord-028721-x6f26ahr 2112 4 may may MD cord-028721-x6f26ahr 2112 5 show show VB cord-028721-x6f26ahr 2112 6 vacuolation vacuolation NN cord-028721-x6f26ahr 2112 7 of of IN cord-028721-x6f26ahr 2112 8 the the DT cord-028721-x6f26ahr 2112 9 apical apical JJ cord-028721-x6f26ahr 2112 10 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2112 11 as as IN cord-028721-x6f26ahr 2112 12 an an DT cord-028721-x6f26ahr 2112 13 expression expression NN cord-028721-x6f26ahr 2112 14 of of IN cord-028721-x6f26ahr 2112 15 germ germ NN cord-028721-x6f26ahr 2112 16 cell cell NN cord-028721-x6f26ahr 2112 17 loss loss NN cord-028721-x6f26ahr 2112 18 . . . cord-028721-x6f26ahr 2113 1 This this DT cord-028721-x6f26ahr 2113 2 lesion lesion NN cord-028721-x6f26ahr 2113 3 is be VBZ cord-028721-x6f26ahr 2113 4 more more RBR cord-028721-x6f26ahr 2113 5 severe severe JJ cord-028721-x6f26ahr 2113 6 than than IN cord-028721-x6f26ahr 2113 7 that that DT cord-028721-x6f26ahr 2113 8 in in IN cord-028721-x6f26ahr 2113 9 testes testis NNS cord-028721-x6f26ahr 2113 10 with with IN cord-028721-x6f26ahr 2113 11 late late JJ cord-028721-x6f26ahr 2113 12 primary primary JJ cord-028721-x6f26ahr 2113 13 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2113 14 sloughing sloughing NN cord-028721-x6f26ahr 2113 15 , , , cord-028721-x6f26ahr 2113 16 and and CC cord-028721-x6f26ahr 2113 17 is be VBZ cord-028721-x6f26ahr 2113 18 considered consider VBN cord-028721-x6f26ahr 2113 19 to to TO cord-028721-x6f26ahr 2113 20 result result VB cord-028721-x6f26ahr 2113 21 from from IN cord-028721-x6f26ahr 2113 22 failure failure NN cord-028721-x6f26ahr 2113 23 of of IN cord-028721-x6f26ahr 2113 24 the the DT cord-028721-x6f26ahr 2113 25 Sertoli Sertoli NNP cord-028721-x6f26ahr 2113 26 cells cell NNS cord-028721-x6f26ahr 2113 27 to to TO cord-028721-x6f26ahr 2113 28 maintain maintain VB cord-028721-x6f26ahr 2113 29 the the DT cord-028721-x6f26ahr 2113 30 adluminal adluminal NNP cord-028721-x6f26ahr 2113 31 compartment compartment NNP cord-028721-x6f26ahr 2113 32 . . . cord-028721-x6f26ahr 2114 1 Etiology etiology NN cord-028721-x6f26ahr 2115 1 The the DT cord-028721-x6f26ahr 2115 2 mechanisms mechanism NNS cord-028721-x6f26ahr 2115 3 causing cause VBG cord-028721-x6f26ahr 2115 4 adluminal adluminal JJ cord-028721-x6f26ahr 2115 5 compartment compartment NN cord-028721-x6f26ahr 2115 6 lesions lesion NNS cord-028721-x6f26ahr 2115 7 can can MD cord-028721-x6f26ahr 2115 8 be be VB cord-028721-x6f26ahr 2115 9 classifi classifi NNP cord-028721-x6f26ahr 2115 10 ed ed NNP cord-028721-x6f26ahr 2115 11 into into IN cord-028721-x6f26ahr 2115 12 obstructive obstructive JJ cord-028721-x6f26ahr 2115 13 and and CC cord-028721-x6f26ahr 2115 14 nonobstructive nonobstructive JJ cord-028721-x6f26ahr 2115 15 . . . cord-028721-x6f26ahr 2116 1 Obstruction obstruction NN cord-028721-x6f26ahr 2116 2 is be VBZ cord-028721-x6f26ahr 2116 3 present present JJ cord-028721-x6f26ahr 2116 4 in in IN cord-028721-x6f26ahr 2116 5 more more JJR cord-028721-x6f26ahr 2116 6 than than IN cord-028721-x6f26ahr 2116 7 70 70 CD cord-028721-x6f26ahr 2116 8 % % NN cord-028721-x6f26ahr 2116 9 of of IN cord-028721-x6f26ahr 2116 10 cases case NNS cord-028721-x6f26ahr 2116 11 , , , cord-028721-x6f26ahr 2116 12 and and CC cord-028721-x6f26ahr 2116 13 is be VBZ cord-028721-x6f26ahr 2116 14 characterized characterize VBN cord-028721-x6f26ahr 2116 15 by by IN cord-028721-x6f26ahr 2116 16 variability variability NN cord-028721-x6f26ahr 2116 17 of of IN cord-028721-x6f26ahr 2116 18 involvement involvement NN cord-028721-x6f26ahr 2116 19 among among IN cord-028721-x6f26ahr 2116 20 lobules lobule NNS cord-028721-x6f26ahr 2116 21 and and CC cord-028721-x6f26ahr 2116 22 the the DT cord-028721-x6f26ahr 2116 23 presence presence NN cord-028721-x6f26ahr 2116 24 of of IN cord-028721-x6f26ahr 2116 25 at at RB cord-028721-x6f26ahr 2116 26 least least RBS cord-028721-x6f26ahr 2116 27 two two CD cord-028721-x6f26ahr 2116 28 of of IN cord-028721-x6f26ahr 2116 29 the the DT cord-028721-x6f26ahr 2116 30 following follow VBG cord-028721-x6f26ahr 2116 31 abnormalities abnormality NNS cord-028721-x6f26ahr 2116 32 : : : cord-028721-x6f26ahr 2116 33 enlargement enlargement NN cord-028721-x6f26ahr 2116 34 of of IN cord-028721-x6f26ahr 2116 35 tubular tubular JJ cord-028721-x6f26ahr 2116 36 diameter diameter NN cord-028721-x6f26ahr 2116 37 and and CC cord-028721-x6f26ahr 2116 38 a a DT cord-028721-x6f26ahr 2116 39 lumen lumen NN cord-028721-x6f26ahr 2116 40 with with IN cord-028721-x6f26ahr 2116 41 remarkable remarkable JJ cord-028721-x6f26ahr 2116 42 differences difference NNS cord-028721-x6f26ahr 2116 43 among among IN cord-028721-x6f26ahr 2116 44 lobules lobule NNS cord-028721-x6f26ahr 2116 45 ; ; : cord-028721-x6f26ahr 2116 46 Sertoli sertoli JJ cord-028721-x6f26ahr 2116 47 cells cell NNS cord-028721-x6f26ahr 2116 48 with with IN cord-028721-x6f26ahr 2116 49 adherens adherens NNP cord-028721-x6f26ahr 2116 50 germ germ NN cord-028721-x6f26ahr 2116 51 cells cell NNS cord-028721-x6f26ahr 2116 52 protruding protrude VBG cord-028721-x6f26ahr 2116 53 into into IN cord-028721-x6f26ahr 2116 54 the the DT cord-028721-x6f26ahr 2116 55 lumen lumen NN cord-028721-x6f26ahr 2116 56 , , , cord-028721-x6f26ahr 2116 57 giving give VBG cord-028721-x6f26ahr 2116 58 an an DT cord-028721-x6f26ahr 2116 59 indented indented JJ cord-028721-x6f26ahr 2116 60 outline outline NN cord-028721-x6f26ahr 2116 61 ; ; : cord-028721-x6f26ahr 2116 62 intense intense JJ cord-028721-x6f26ahr 2116 63 apical apical JJ cord-028721-x6f26ahr 2116 64 vacuolation vacuolation NN cord-028721-x6f26ahr 2116 65 of of IN cord-028721-x6f26ahr 2116 66 Sertoli sertoli JJ cord-028721-x6f26ahr 2116 67 cell cell NN cord-028721-x6f26ahr 2116 68 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2116 69 ; ; : cord-028721-x6f26ahr 2116 70 accumulation accumulation NN cord-028721-x6f26ahr 2116 71 of of IN cord-028721-x6f26ahr 2116 72 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2116 73 in in IN cord-028721-x6f26ahr 2116 74 the the DT cord-028721-x6f26ahr 2116 75 lumen lumen NN cord-028721-x6f26ahr 2116 76 of of IN cord-028721-x6f26ahr 2116 77 some some DT cord-028721-x6f26ahr 2116 78 tubules tubule NNS cord-028721-x6f26ahr 2116 79 ; ; : cord-028721-x6f26ahr 2116 80 or or CC cord-028721-x6f26ahr 2116 81 number number NN cord-028721-x6f26ahr 2116 82 of of IN cord-028721-x6f26ahr 2116 83 spermatids spermatids NNP cord-028721-x6f26ahr 2116 84 S S NNP cord-028721-x6f26ahr 2116 85 c c NN cord-028721-x6f26ahr 2116 86 + + CC cord-028721-x6f26ahr 2116 87 S s NN cord-028721-x6f26ahr 2116 88 d d NN cord-028721-x6f26ahr 2116 89 is be VBZ cord-028721-x6f26ahr 2116 90 higher high JJR cord-028721-x6f26ahr 2116 91 that that IN cord-028721-x6f26ahr 2116 92 that that DT cord-028721-x6f26ahr 2116 93 of of IN cord-028721-x6f26ahr 2116 94 S S NNP cord-028721-x6f26ahr 2116 95 a a DT cord-028721-x6f26ahr 2117 1 + + CC cord-028721-x6f26ahr 2117 2 S s NN cord-028721-x6f26ahr 2117 3 b b NNP cord-028721-x6f26ahr 2117 4 ( ( -LRB- cord-028721-x6f26ahr 2117 5 see see VB cord-028721-x6f26ahr 2118 1 Testicular testicular JJ cord-028721-x6f26ahr 2118 2 lesions lesion NNS cord-028721-x6f26ahr 2118 3 resulting result VBG cord-028721-x6f26ahr 2118 4 from from IN cord-028721-x6f26ahr 2118 5 obstruction obstruction NN cord-028721-x6f26ahr 2118 6 of of IN cord-028721-x6f26ahr 2118 7 sperm sperm NN cord-028721-x6f26ahr 2118 8 excretory excretory JJ cord-028721-x6f26ahr 2118 9 ducts duct NNS cord-028721-x6f26ahr 2118 10 ) ) -RRB- cord-028721-x6f26ahr 2118 11 . . . cord-028721-x6f26ahr 2119 1 929 929 CD cord-028721-x6f26ahr 2120 1 The the DT cord-028721-x6f26ahr 2120 2 three three CD cord-028721-x6f26ahr 2120 3 levels level NNS cord-028721-x6f26ahr 2120 4 of of IN cord-028721-x6f26ahr 2120 5 severity severity NN cord-028721-x6f26ahr 2120 6 of of IN cord-028721-x6f26ahr 2120 7 adluminal adluminal NNP cord-028721-x6f26ahr 2120 8 compartment compartment NN cord-028721-x6f26ahr 2120 9 lesions lesion NNS cord-028721-x6f26ahr 2120 10 emphasized emphasize VBN cord-028721-x6f26ahr 2120 11 by by IN cord-028721-x6f26ahr 2120 12 the the DT cord-028721-x6f26ahr 2120 13 terms term NNS cord-028721-x6f26ahr 2120 14 young young JJ cord-028721-x6f26ahr 2120 15 spermatid spermatid NN cord-028721-x6f26ahr 2120 16 sloughing slough VBG cord-028721-x6f26ahr 2120 17 , , , cord-028721-x6f26ahr 2120 18 later later JJ cord-028721-x6f26ahr 2120 19 primary primary JJ cord-028721-x6f26ahr 2120 20 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2120 21 sloughing slough VBG cord-028721-x6f26ahr 2120 22 , , , cord-028721-x6f26ahr 2120 23 and and CC cord-028721-x6f26ahr 2120 24 early early JJ cord-028721-x6f26ahr 2120 25 primary primary JJ cord-028721-x6f26ahr 2120 26 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2120 27 sloughing sloughing NN cord-028721-x6f26ahr 2120 28 , , , cord-028721-x6f26ahr 2120 29 depend depend VB cord-028721-x6f26ahr 2120 30 on on IN cord-028721-x6f26ahr 2120 31 the the DT cord-028721-x6f26ahr 2120 32 degree degree NN cord-028721-x6f26ahr 2120 33 ( ( -LRB- cord-028721-x6f26ahr 2120 34 total total JJ cord-028721-x6f26ahr 2120 35 or or CC cord-028721-x6f26ahr 2120 36 partial partial JJ cord-028721-x6f26ahr 2120 37 ) ) -RRB- cord-028721-x6f26ahr 2120 38 of of IN cord-028721-x6f26ahr 2120 39 obstruction obstruction NN cord-028721-x6f26ahr 2120 40 and and CC cord-028721-x6f26ahr 2120 41 the the DT cord-028721-x6f26ahr 2120 42 level level NN cord-028721-x6f26ahr 2120 43 of of IN cord-028721-x6f26ahr 2120 44 sperm sperm NN cord-028721-x6f26ahr 2120 45 excretory excretory JJ cord-028721-x6f26ahr 2120 46 duct duct NN cord-028721-x6f26ahr 2120 47 obstruction obstruction NN cord-028721-x6f26ahr 2120 48 : : : cord-028721-x6f26ahr 2120 49 as as IN cord-028721-x6f26ahr 2120 50 the the DT cord-028721-x6f26ahr 2120 51 obstruction obstruction NN cord-028721-x6f26ahr 2120 52 gets get VBZ cord-028721-x6f26ahr 2120 53 nearer near JJR cord-028721-x6f26ahr 2120 54 to to IN cord-028721-x6f26ahr 2120 55 the the DT cord-028721-x6f26ahr 2120 56 testis testis NN cord-028721-x6f26ahr 2120 57 , , , cord-028721-x6f26ahr 2120 58 the the DT cord-028721-x6f26ahr 2120 59 greater great JJR cord-028721-x6f26ahr 2120 60 the the DT cord-028721-x6f26ahr 2120 61 severity severity NN cord-028721-x6f26ahr 2120 62 . . . cord-028721-x6f26ahr 2121 1 Obstruction obstruction NN cord-028721-x6f26ahr 2121 2 may may MD cord-028721-x6f26ahr 2121 3 be be VB cord-028721-x6f26ahr 2121 4 extratesticular extratesticular JJ cord-028721-x6f26ahr 2121 5 ( ( -LRB- cord-028721-x6f26ahr 2121 6 epididymis epididymis NN cord-028721-x6f26ahr 2121 7 , , , cord-028721-x6f26ahr 2121 8 vas vas NNP cord-028721-x6f26ahr 2121 9 deferens deferens NNP cord-028721-x6f26ahr 2121 10 , , , cord-028721-x6f26ahr 2121 11 and and CC cord-028721-x6f26ahr 2121 12 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2121 13 ducts duct NNS cord-028721-x6f26ahr 2121 14 ) ) -RRB- cord-028721-x6f26ahr 2121 15 or or CC cord-028721-x6f26ahr 2121 16 intratesticular intratesticular NNP cord-028721-x6f26ahr 2121 17 ( ( -LRB- cord-028721-x6f26ahr 2121 18 rete rete FW cord-028721-x6f26ahr 2121 19 testis testis NN cord-028721-x6f26ahr 2121 20 or or CC cord-028721-x6f26ahr 2121 21 any any DT cord-028721-x6f26ahr 2121 22 level level NN cord-028721-x6f26ahr 2121 23 of of IN cord-028721-x6f26ahr 2121 24 the the DT cord-028721-x6f26ahr 2121 25 seminiferous seminiferous JJ cord-028721-x6f26ahr 2121 26 tubule tubule NN cord-028721-x6f26ahr 2121 27 length length NN cord-028721-x6f26ahr 2121 28 ) ) -RRB- cord-028721-x6f26ahr 2121 29 . . . cord-028721-x6f26ahr 2122 1 The the DT cord-028721-x6f26ahr 2122 2 most most RBS cord-028721-x6f26ahr 2122 3 frequent frequent JJ cord-028721-x6f26ahr 2122 4 causes cause NNS cord-028721-x6f26ahr 2122 5 of of IN cord-028721-x6f26ahr 2122 6 extratesticular extratesticular JJ cord-028721-x6f26ahr 2122 7 excretory excretory JJ cord-028721-x6f26ahr 2122 8 duct duct NN cord-028721-x6f26ahr 2122 9 obstruction obstruction NN cord-028721-x6f26ahr 2122 10 are be VBP cord-028721-x6f26ahr 2122 11 vasectomy vasectomy NN cord-028721-x6f26ahr 2122 12 , , , cord-028721-x6f26ahr 2122 13 infl infl NNP cord-028721-x6f26ahr 2122 14 ammation ammation NNP cord-028721-x6f26ahr 2122 15 ( ( -LRB- cord-028721-x6f26ahr 2122 16 epididymitis epididymitis NN cord-028721-x6f26ahr 2122 17 , , , cord-028721-x6f26ahr 2122 18 prostatitis prostatitis NN cord-028721-x6f26ahr 2122 19 ) ) -RRB- cord-028721-x6f26ahr 2122 20 , , , cord-028721-x6f26ahr 2122 21 mucoviscidosis mucoviscidosis NNP cord-028721-x6f26ahr 2122 22 ( ( -LRB- cord-028721-x6f26ahr 2122 23 congenital congenital JJ cord-028721-x6f26ahr 2122 24 bilateral bilateral JJ cord-028721-x6f26ahr 2122 25 absence absence NN cord-028721-x6f26ahr 2122 26 of of IN cord-028721-x6f26ahr 2122 27 vas vas NNP cord-028721-x6f26ahr 2122 28 deferens deferens NNP cord-028721-x6f26ahr 2122 29 ) ) -RRB- cord-028721-x6f26ahr 2122 30 , , , cord-028721-x6f26ahr 2122 31 and and CC cord-028721-x6f26ahr 2122 32 testis testis NN cord-028721-x6f26ahr 2122 33 - - HYPH cord-028721-x6f26ahr 2122 34 epididymis epididymis NN cord-028721-x6f26ahr 2122 35 dissociation dissociation NN cord-028721-x6f26ahr 2122 36 . . . cord-028721-x6f26ahr 2123 1 Rete Rete NNP cord-028721-x6f26ahr 2123 2 testis testis NN cord-028721-x6f26ahr 2123 3 obstruction obstruction NN cord-028721-x6f26ahr 2123 4 . . . cord-028721-x6f26ahr 2124 1 Varicocele Varicocele NNP cord-028721-x6f26ahr 2124 2 is be VBZ cord-028721-x6f26ahr 2124 3 the the DT cord-028721-x6f26ahr 2124 4 most most RBS cord-028721-x6f26ahr 2124 5 frequent frequent JJ cord-028721-x6f26ahr 2124 6 cause cause NN cord-028721-x6f26ahr 2124 7 of of IN cord-028721-x6f26ahr 2124 8 obstruction obstruction NN cord-028721-x6f26ahr 2124 9 of of IN cord-028721-x6f26ahr 2124 10 the the DT cord-028721-x6f26ahr 2124 11 rete rete NN cord-028721-x6f26ahr 2124 12 testis testis NN cord-028721-x6f26ahr 2124 13 . . . cord-028721-x6f26ahr 2125 1 More More JJR cord-028721-x6f26ahr 2125 2 than than IN cord-028721-x6f26ahr 2125 3 50 50 CD cord-028721-x6f26ahr 2125 4 % % NN cord-028721-x6f26ahr 2125 5 of of IN cord-028721-x6f26ahr 2125 6 testes testis NNS cord-028721-x6f26ahr 2125 7 with with IN cord-028721-x6f26ahr 2125 8 Varicocele Varicocele NNP cord-028721-x6f26ahr 2125 9 patients patient NNS cord-028721-x6f26ahr 2125 10 also also RB cord-028721-x6f26ahr 2125 11 often often RB cord-028721-x6f26ahr 2125 12 have have VBP cord-028721-x6f26ahr 2125 13 spermatozoa spermatozoa VBN cord-028721-x6f26ahr 2125 14 with with IN cord-028721-x6f26ahr 2125 15 characteristically characteristically RB cord-028721-x6f26ahr 2125 16 elongated elongated JJ cord-028721-x6f26ahr 2125 17 heads head NNS cord-028721-x6f26ahr 2125 18 with with IN cord-028721-x6f26ahr 2125 19 thin thin JJ cord-028721-x6f26ahr 2125 20 bases basis NNS cord-028721-x6f26ahr 2125 21 . . . cord-028721-x6f26ahr 2126 1 930 930 CD cord-028721-x6f26ahr 2126 2 Initially initially RB cord-028721-x6f26ahr 2126 3 , , , cord-028721-x6f26ahr 2126 4 abnormalities abnormality NNS cord-028721-x6f26ahr 2126 5 are be VBP cord-028721-x6f26ahr 2126 6 confi confi NNP cord-028721-x6f26ahr 2126 7 ned ned NNP cord-028721-x6f26ahr 2126 8 to to IN cord-028721-x6f26ahr 2126 9 the the DT cord-028721-x6f26ahr 2126 10 testis testis NN cord-028721-x6f26ahr 2126 11 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2126 12 to to IN cord-028721-x6f26ahr 2126 13 the the DT cord-028721-x6f26ahr 2126 14 varicocele varicocele NN cord-028721-x6f26ahr 2126 15 , , , cord-028721-x6f26ahr 2126 16 but but CC cord-028721-x6f26ahr 2126 17 eventually eventually RB cord-028721-x6f26ahr 2126 18 both both DT cord-028721-x6f26ahr 2126 19 testes testis NNS cord-028721-x6f26ahr 2126 20 are be VBP cord-028721-x6f26ahr 2126 21 affected affect VBN cord-028721-x6f26ahr 2126 22 , , , cord-028721-x6f26ahr 2126 23 although although IN cord-028721-x6f26ahr 2126 24 abnormalities abnormality NNS cord-028721-x6f26ahr 2126 25 are be VBP cord-028721-x6f26ahr 2126 26 more more RBR cord-028721-x6f26ahr 2126 27 severe severe JJ cord-028721-x6f26ahr 2126 28 in in IN cord-028721-x6f26ahr 2126 29 the the DT cord-028721-x6f26ahr 2126 30 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2126 31 testis testis NN cord-028721-x6f26ahr 2126 32 . . . cord-028721-x6f26ahr 2127 1 Elevated elevated JJ cord-028721-x6f26ahr 2127 2 pressure pressure NN cord-028721-x6f26ahr 2127 3 in in IN cord-028721-x6f26ahr 2127 4 the the DT cord-028721-x6f26ahr 2127 5 pampiniform pampiniform NNP cord-028721-x6f26ahr 2127 6 plexus plexus NNP cord-028721-x6f26ahr 2127 7 is be VBZ cord-028721-x6f26ahr 2127 8 transmitted transmit VBN cord-028721-x6f26ahr 2127 9 to to IN cord-028721-x6f26ahr 2127 10 the the DT cord-028721-x6f26ahr 2127 11 veins vein NNS cord-028721-x6f26ahr 2127 12 within within IN cord-028721-x6f26ahr 2127 13 the the DT cord-028721-x6f26ahr 2127 14 testes testis NNS cord-028721-x6f26ahr 2127 15 , , , cord-028721-x6f26ahr 2127 16 principally principally RB cord-028721-x6f26ahr 2127 17 to to IN cord-028721-x6f26ahr 2127 18 the the DT cord-028721-x6f26ahr 2127 19 centripetal centripetal JJ cord-028721-x6f26ahr 2127 20 veins vein NNS cord-028721-x6f26ahr 2127 21 that that WDT cord-028721-x6f26ahr 2127 22 cross cross VBP cord-028721-x6f26ahr 2127 23 the the DT cord-028721-x6f26ahr 2127 24 testicular testicular NN cord-028721-x6f26ahr 2127 25 mediastinum mediastinum NN cord-028721-x6f26ahr 2127 26 and and CC cord-028721-x6f26ahr 2127 27 drain drain VB cord-028721-x6f26ahr 2127 28 most most JJS cord-028721-x6f26ahr 2127 29 of of IN cord-028721-x6f26ahr 2127 30 the the DT cord-028721-x6f26ahr 2127 31 testicular testicular JJ cord-028721-x6f26ahr 2127 32 parenchyma parenchyma NN cord-028721-x6f26ahr 2128 1 ( ( -LRB- cord-028721-x6f26ahr 2128 2 Fig Fig NNP cord-028721-x6f26ahr 2128 3 . . . cord-028721-x6f26ahr 2128 4 12 12 CD cord-028721-x6f26ahr 2128 5 - - SYM cord-028721-x6f26ahr 2128 6 100 100 CD cord-028721-x6f26ahr 2128 7 ) ) -RRB- cord-028721-x6f26ahr 2128 8 . . . cord-028721-x6f26ahr 2129 1 931 931 CD cord-028721-x6f26ahr 2130 1 The the DT cord-028721-x6f26ahr 2130 2 dilated dilated JJ cord-028721-x6f26ahr 2130 3 centripetal centripetal JJ cord-028721-x6f26ahr 2130 4 veins vein NNS cord-028721-x6f26ahr 2130 5 compress compress VBP cord-028721-x6f26ahr 2130 6 the the DT cord-028721-x6f26ahr 2130 7 intratesticular intratesticular JJ cord-028721-x6f26ahr 2130 8 sperm sperm NN cord-028721-x6f26ahr 2130 9 excretory excretory JJ cord-028721-x6f26ahr 2130 10 ducts duct NNS cord-028721-x6f26ahr 2130 11 , , , cord-028721-x6f26ahr 2130 12 explaining explain VBG cord-028721-x6f26ahr 2130 13 the the DT cord-028721-x6f26ahr 2130 14 mosaic mosaic JJ cord-028721-x6f26ahr 2130 15 distribution distribution NN cord-028721-x6f26ahr 2130 16 of of IN cord-028721-x6f26ahr 2130 17 the the DT cord-028721-x6f26ahr 2130 18 tubular tubular JJ cord-028721-x6f26ahr 2130 19 lesions lesion NNS cord-028721-x6f26ahr 2130 20 . . . cord-028721-x6f26ahr 2131 1 932 932 CD cord-028721-x6f26ahr 2131 2 Seminiferous seminiferous JJ cord-028721-x6f26ahr 2131 3 tubule tubule NN cord-028721-x6f26ahr 2131 4 obstruction obstruction NN cord-028721-x6f26ahr 2131 5 . . . cord-028721-x6f26ahr 2132 1 Obstruction obstruction NN cord-028721-x6f26ahr 2132 2 at at IN cord-028721-x6f26ahr 2132 3 the the DT cord-028721-x6f26ahr 2132 4 level level NN cord-028721-x6f26ahr 2132 5 of of IN cord-028721-x6f26ahr 2132 6 the the DT cord-028721-x6f26ahr 2132 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 2132 8 tubules tubule NNS cord-028721-x6f26ahr 2132 9 can can MD cord-028721-x6f26ahr 2132 10 be be VB cord-028721-x6f26ahr 2132 11 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2132 12 or or CC cord-028721-x6f26ahr 2132 13 post post JJ cord-028721-x6f26ahr 2132 14 - - JJ cord-028721-x6f26ahr 2132 15 orchitic orchitic JJ cord-028721-x6f26ahr 2132 16 . . . cord-028721-x6f26ahr 2133 1 A a DT cord-028721-x6f26ahr 2133 2 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2133 3 cause cause NN cord-028721-x6f26ahr 2133 4 may may MD cord-028721-x6f26ahr 2133 5 be be VB cord-028721-x6f26ahr 2133 6 suspected suspect VBN cord-028721-x6f26ahr 2133 7 in in IN cord-028721-x6f26ahr 2133 8 specimens specimen NNS cord-028721-x6f26ahr 2133 9 with with IN cord-028721-x6f26ahr 2133 10 a a DT cord-028721-x6f26ahr 2133 11 mosaic mosaic JJ cord-028721-x6f26ahr 2133 12 distribution distribution NN cord-028721-x6f26ahr 2133 13 of of IN cord-028721-x6f26ahr 2133 14 lesions lesion NNS cord-028721-x6f26ahr 2133 15 and and CC cord-028721-x6f26ahr 2133 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 2133 17 tubules tubule NNS cord-028721-x6f26ahr 2133 18 with with IN cord-028721-x6f26ahr 2133 19 small small JJ cord-028721-x6f26ahr 2133 20 diameters diameter NNS cord-028721-x6f26ahr 2133 21 , , , cord-028721-x6f26ahr 2133 22 thickened thicken VBN cord-028721-x6f26ahr 2133 23 lamina lamina NN cord-028721-x6f26ahr 2133 24 propria propria NN cord-028721-x6f26ahr 2133 25 , , , cord-028721-x6f26ahr 2133 26 and and CC cord-028721-x6f26ahr 2133 27 an an DT cord-028721-x6f26ahr 2133 28 unusual unusual JJ cord-028721-x6f26ahr 2133 29 seminiferous seminiferous JJ cord-028721-x6f26ahr 2133 30 tubular tubular JJ cord-028721-x6f26ahr 2133 31 cell cell NN cord-028721-x6f26ahr 2133 32 layer layer NN cord-028721-x6f26ahr 2133 33 consisting consist VBG cord-028721-x6f26ahr 2133 34 of of IN cord-028721-x6f26ahr 2133 35 cuboidal cuboidal JJ cord-028721-x6f26ahr 2133 36 Sertoli sertoli JJ cord-028721-x6f26ahr 2133 37 cells cell NNS cord-028721-x6f26ahr 2133 38 and and CC cord-028721-x6f26ahr 2133 39 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2133 40 that that WDT cord-028721-x6f26ahr 2133 41 clog clog VBP cord-028721-x6f26ahr 2133 42 the the DT cord-028721-x6f26ahr 2133 43 lumina lumina NNP cord-028721-x6f26ahr 2133 44 ( ( -LRB- cord-028721-x6f26ahr 2133 45 Fig Fig NNP cord-028721-x6f26ahr 2133 46 . . . cord-028721-x6f26ahr 2133 47 12 12 CD cord-028721-x6f26ahr 2133 48 - - SYM cord-028721-x6f26ahr 2133 49 101 101 CD cord-028721-x6f26ahr 2133 50 ) ) -RRB- cord-028721-x6f26ahr 2133 51 . . . cord-028721-x6f26ahr 2134 1 The the DT cord-028721-x6f26ahr 2134 2 diagnosis diagnosis NN cord-028721-x6f26ahr 2134 3 is be VBZ cord-028721-x6f26ahr 2134 4 confi confi NNP cord-028721-x6f26ahr 2134 5 rmed rme VBN cord-028721-x6f26ahr 2134 6 if if IN cord-028721-x6f26ahr 2134 7 study study NN cord-028721-x6f26ahr 2134 8 of of IN cord-028721-x6f26ahr 2134 9 serial serial JJ cord-028721-x6f26ahr 2134 10 sections section NNS cord-028721-x6f26ahr 2134 11 demonstrates demonstrate VBZ cord-028721-x6f26ahr 2134 12 continuity continuity NN cord-028721-x6f26ahr 2134 13 between between IN cord-028721-x6f26ahr 2134 14 these these DT cord-028721-x6f26ahr 2134 15 tubules tubule NNS cord-028721-x6f26ahr 2134 16 and and CC cord-028721-x6f26ahr 2134 17 those those DT cord-028721-x6f26ahr 2134 18 with with IN cord-028721-x6f26ahr 2134 19 conserved conserved JJ cord-028721-x6f26ahr 2134 20 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2134 21 . . . cord-028721-x6f26ahr 2135 1 The the DT cord-028721-x6f26ahr 2135 2 structure structure NN cord-028721-x6f26ahr 2135 3 of of IN cord-028721-x6f26ahr 2135 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 2135 5 tubules tubule NNS cord-028721-x6f26ahr 2135 6 has have VBZ cord-028721-x6f26ahr 2135 7 been be VBN cord-028721-x6f26ahr 2135 8 observed observe VBN cord-028721-x6f26ahr 2135 9 with with IN cord-028721-x6f26ahr 2135 10 scanning scanning NN cord-028721-x6f26ahr 2135 11 microscopy microscopy NNS cord-028721-x6f26ahr 2135 12 at at IN cord-028721-x6f26ahr 2135 13 such such JJ cord-028721-x6f26ahr 2135 14 points point NNS cord-028721-x6f26ahr 2135 15 of of IN cord-028721-x6f26ahr 2135 16 continuity continuity NN cord-028721-x6f26ahr 2135 17 . . . cord-028721-x6f26ahr 2136 1 858 858 CD cord-028721-x6f26ahr 2136 2 , , , cord-028721-x6f26ahr 2136 3 933 933 CD cord-028721-x6f26ahr 2136 4 Tubular tubular JJ cord-028721-x6f26ahr 2136 5 stenosis stenosis NN cord-028721-x6f26ahr 2136 6 appears appear VBZ cord-028721-x6f26ahr 2136 7 to to TO cord-028721-x6f26ahr 2136 8 be be VB cord-028721-x6f26ahr 2136 9 due due JJ cord-028721-x6f26ahr 2136 10 to to IN cord-028721-x6f26ahr 2136 11 a a DT cord-028721-x6f26ahr 2136 12 primary primary JJ cord-028721-x6f26ahr 2136 13 anomaly anomaly NN cord-028721-x6f26ahr 2136 14 of of IN cord-028721-x6f26ahr 2136 15 Sertoli Sertoli NNP cord-028721-x6f26ahr 2136 16 cells cell NNS cord-028721-x6f26ahr 2136 17 and and CC cord-028721-x6f26ahr 2136 18 peritubular peritubular JJ cord-028721-x6f26ahr 2136 19 cells cell NNS cord-028721-x6f26ahr 2136 20 . . . cord-028721-x6f26ahr 2137 1 Post post JJ cord-028721-x6f26ahr 2137 2 - - JJ cord-028721-x6f26ahr 2137 3 orchitic orchitic JJ cord-028721-x6f26ahr 2137 4 obstruction obstruction NN cord-028721-x6f26ahr 2137 5 should should MD cord-028721-x6f26ahr 2137 6 be be VB cord-028721-x6f26ahr 2137 7 suspected suspect VBN cord-028721-x6f26ahr 2137 8 in in IN cord-028721-x6f26ahr 2137 9 cases case NNS cord-028721-x6f26ahr 2137 10 of of IN cord-028721-x6f26ahr 2137 11 tubular tubular JJ cord-028721-x6f26ahr 2137 12 atrophy atrophy NN cord-028721-x6f26ahr 2137 13 with with IN cord-028721-x6f26ahr 2137 14 a a DT cord-028721-x6f26ahr 2137 15 mosaic mosaic JJ cord-028721-x6f26ahr 2137 16 pattern pattern NN cord-028721-x6f26ahr 2137 17 without without IN cord-028721-x6f26ahr 2137 18 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2137 19 tubules tubule NNS cord-028721-x6f26ahr 2137 20 or or CC cord-028721-x6f26ahr 2137 21 varicocele varicocele NN cord-028721-x6f26ahr 2137 22 . . . cord-028721-x6f26ahr 2138 1 Some some DT cord-028721-x6f26ahr 2138 2 patients patient NNS cord-028721-x6f26ahr 2138 3 have have VBP cord-028721-x6f26ahr 2138 4 a a DT cord-028721-x6f26ahr 2138 5 history history NN cord-028721-x6f26ahr 2138 6 of of IN cord-028721-x6f26ahr 2138 7 orchitis orchitis NN cord-028721-x6f26ahr 2138 8 associated associate VBN cord-028721-x6f26ahr 2138 9 with with IN cord-028721-x6f26ahr 2138 10 parotiditis parotiditis NNP cord-028721-x6f26ahr 2138 11 ; ; : cord-028721-x6f26ahr 2138 12 934 934 CD cord-028721-x6f26ahr 2138 13 in in IN cord-028721-x6f26ahr 2138 14 others other NNS cord-028721-x6f26ahr 2138 15 the the DT cord-028721-x6f26ahr 2138 16 only only JJ cord-028721-x6f26ahr 2138 17 fi fi NNP cord-028721-x6f26ahr 2138 18 ndings nding NNS cord-028721-x6f26ahr 2138 19 are be VBP cord-028721-x6f26ahr 2138 20 oligozoospermia oligozoospermia JJ cord-028721-x6f26ahr 2138 21 and and CC cord-028721-x6f26ahr 2138 22 small small JJ cord-028721-x6f26ahr 2138 23 testes testis NNS cord-028721-x6f26ahr 2138 24 . . . cord-028721-x6f26ahr 2139 1 Testicular testicular JJ cord-028721-x6f26ahr 2139 2 biopsy biopsy NN cord-028721-x6f26ahr 2139 3 , , , cord-028721-x6f26ahr 2139 4 sampling sample VBG cord-028721-x6f26ahr 2139 5 only only RB cord-028721-x6f26ahr 2139 6 the the DT cord-028721-x6f26ahr 2139 7 testicular testicular NN cord-028721-x6f26ahr 2139 8 periphery periphery NN cord-028721-x6f26ahr 2139 9 , , , cord-028721-x6f26ahr 2139 10 reveals reveal VBZ cord-028721-x6f26ahr 2139 11 only only RB cord-028721-x6f26ahr 2139 12 the the DT cord-028721-x6f26ahr 2139 13 consequences consequence NNS cord-028721-x6f26ahr 2139 14 of of IN cord-028721-x6f26ahr 2139 15 obstruction obstruction NN cord-028721-x6f26ahr 2139 16 , , , cord-028721-x6f26ahr 2139 17 lesions lesion NNS cord-028721-x6f26ahr 2139 18 similar similar JJ cord-028721-x6f26ahr 2139 19 to to IN cord-028721-x6f26ahr 2139 20 those those DT cord-028721-x6f26ahr 2139 21 observed observe VBN cord-028721-x6f26ahr 2139 22 with with IN cord-028721-x6f26ahr 2139 23 varicocele varicocele NN cord-028721-x6f26ahr 2139 24 . . . cord-028721-x6f26ahr 2140 1 However however RB cord-028721-x6f26ahr 2140 2 , , , cord-028721-x6f26ahr 2140 3 some some DT cord-028721-x6f26ahr 2140 4 postinfl postinfl NN cord-028721-x6f26ahr 2140 5 ammatory ammatory NN cord-028721-x6f26ahr 2140 6 changes change NNS cord-028721-x6f26ahr 2140 7 should should MD cord-028721-x6f26ahr 2140 8 also also RB cord-028721-x6f26ahr 2140 9 be be VB cord-028721-x6f26ahr 2140 10 present present JJ cord-028721-x6f26ahr 2140 11 , , , cord-028721-x6f26ahr 2140 12 including include VBG cord-028721-x6f26ahr 2140 13 hyalinized hyalinize VBN cord-028721-x6f26ahr 2140 14 tubules tubule NNS cord-028721-x6f26ahr 2140 15 , , , cord-028721-x6f26ahr 2140 16 dilated dilated JJ cord-028721-x6f26ahr 2140 17 tubules tubule NNS cord-028721-x6f26ahr 2140 18 lined line VBN cord-028721-x6f26ahr 2140 19 by by IN cord-028721-x6f26ahr 2140 20 cuboidal cuboidal JJ cord-028721-x6f26ahr 2140 21 Sertoli sertoli JJ cord-028721-x6f26ahr 2140 22 cells cell NNS cord-028721-x6f26ahr 2140 23 , , , cord-028721-x6f26ahr 2140 24 or or CC cord-028721-x6f26ahr 2140 25 complete complete JJ cord-028721-x6f26ahr 2140 26 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2140 27 . . . cord-028721-x6f26ahr 2141 1 Occasionally occasionally RB cord-028721-x6f26ahr 2141 2 , , , cord-028721-x6f26ahr 2141 3 there there EX cord-028721-x6f26ahr 2141 4 is be VBZ cord-028721-x6f26ahr 2141 5 modest modest JJ cord-028721-x6f26ahr 2141 6 perivascular perivascular JJ cord-028721-x6f26ahr 2141 7 or or CC cord-028721-x6f26ahr 2141 8 peritubular peritubular NNP cord-028721-x6f26ahr 2141 9 infl infl NNP cord-028721-x6f26ahr 2141 10 ammation ammation NNP cord-028721-x6f26ahr 2141 11 and and CC cord-028721-x6f26ahr 2141 12 angiectasis angiectasis NN cord-028721-x6f26ahr 2141 13 . . . cord-028721-x6f26ahr 2142 1 935 935 CD cord-028721-x6f26ahr 2142 2 , , , cord-028721-x6f26ahr 2142 3 936 936 CD cord-028721-x6f26ahr 2142 4 About about IN cord-028721-x6f26ahr 2142 5 30 30 CD cord-028721-x6f26ahr 2142 6 % % NN cord-028721-x6f26ahr 2142 7 of of IN cord-028721-x6f26ahr 2142 8 testes testis NNS cord-028721-x6f26ahr 2142 9 with with IN cord-028721-x6f26ahr 2142 10 lesions lesion NNS cord-028721-x6f26ahr 2142 11 in in IN cord-028721-x6f26ahr 2142 12 the the DT cord-028721-x6f26ahr 2142 13 adluminal adluminal NNP cord-028721-x6f26ahr 2142 14 compartment compartment NNP cord-028721-x6f26ahr 2142 15 have have VBP cord-028721-x6f26ahr 2142 16 no no DT cord-028721-x6f26ahr 2142 17 obstruction obstruction NN cord-028721-x6f26ahr 2142 18 , , , cord-028721-x6f26ahr 2142 19 and and CC cord-028721-x6f26ahr 2142 20 most most JJS cord-028721-x6f26ahr 2142 21 have have VBP cord-028721-x6f26ahr 2142 22 primary primary JJ cord-028721-x6f26ahr 2142 23 anomalies anomaly NNS cord-028721-x6f26ahr 2142 24 of of IN cord-028721-x6f26ahr 2142 25 germ germ NN cord-028721-x6f26ahr 2142 26 cells cell NNS cord-028721-x6f26ahr 2142 27 . . . cord-028721-x6f26ahr 2143 1 This this DT cord-028721-x6f26ahr 2143 2 claim claim NN cord-028721-x6f26ahr 2143 3 is be VBZ cord-028721-x6f26ahr 2143 4 supported support VBN cord-028721-x6f26ahr 2143 5 by by IN cord-028721-x6f26ahr 2143 6 the the DT cord-028721-x6f26ahr 2143 7 following follow VBG cord-028721-x6f26ahr 2143 8 : : : cord-028721-x6f26ahr 2143 9 pronounced pronounce VBN cord-028721-x6f26ahr 2143 10 decrease decrease NN cord-028721-x6f26ahr 2143 11 of of IN cord-028721-x6f26ahr 2143 12 germ germ NN cord-028721-x6f26ahr 2143 13 cell cell NN cord-028721-x6f26ahr 2143 14 type type NN cord-028721-x6f26ahr 2143 15 when when WRB cord-028721-x6f26ahr 2143 16 the the DT cord-028721-x6f26ahr 2143 17 preceding precede VBG cord-028721-x6f26ahr 2143 18 type type NN cord-028721-x6f26ahr 2143 19 is be VBZ cord-028721-x6f26ahr 2143 20 greatly greatly RB cord-028721-x6f26ahr 2143 21 increased increase VBN cord-028721-x6f26ahr 2143 22 in in IN cord-028721-x6f26ahr 2143 23 number number NN cord-028721-x6f26ahr 2143 24 ; ; , cord-028721-x6f26ahr 2143 25 normal normal JJ cord-028721-x6f26ahr 2143 26 correlation correlation NN cord-028721-x6f26ahr 2143 27 between between IN cord-028721-x6f26ahr 2143 28 the the DT cord-028721-x6f26ahr 2143 29 number number NN cord-028721-x6f26ahr 2143 30 of of IN cord-028721-x6f26ahr 2143 31 mature mature JJ cord-028721-x6f26ahr 2143 32 spermatids spermatid NNS cord-028721-x6f26ahr 2143 33 in in IN cord-028721-x6f26ahr 2143 34 biopsy biopsy NN cord-028721-x6f26ahr 2143 35 and and CC cord-028721-x6f26ahr 2143 36 number number NN cord-028721-x6f26ahr 2143 37 of of IN cord-028721-x6f26ahr 2143 38 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2143 39 in in IN cord-028721-x6f26ahr 2143 40 the the DT cord-028721-x6f26ahr 2143 41 spermiogram spermiogram NNP cord-028721-x6f26ahr 2143 42 ; ; : cord-028721-x6f26ahr 2143 43 and and CC cord-028721-x6f26ahr 2143 44 the the DT cord-028721-x6f26ahr 2143 45 presence presence NN cord-028721-x6f26ahr 2143 46 of of IN cord-028721-x6f26ahr 2143 47 numerous numerous JJ cord-028721-x6f26ahr 2143 48 malformed malformed JJ cord-028721-x6f26ahr 2143 49 germ germ NN cord-028721-x6f26ahr 2143 50 cells cell NNS cord-028721-x6f26ahr 2143 51 in in IN cord-028721-x6f26ahr 2143 52 the the DT cord-028721-x6f26ahr 2143 53 adluminal adluminal NNP cord-028721-x6f26ahr 2143 54 compartment compartment NNP cord-028721-x6f26ahr 2143 55 . . . cord-028721-x6f26ahr 2144 1 Decrease decrease VB cord-028721-x6f26ahr 2144 2 in in IN cord-028721-x6f26ahr 2144 3 the the DT cord-028721-x6f26ahr 2144 4 number number NN cord-028721-x6f26ahr 2144 5 of of IN cord-028721-x6f26ahr 2144 6 a a DT cord-028721-x6f26ahr 2144 7 germ germ NN cord-028721-x6f26ahr 2144 8 cell cell NN cord-028721-x6f26ahr 2144 9 type type NN cord-028721-x6f26ahr 2144 10 may may MD cord-028721-x6f26ahr 2144 11 be be VB cord-028721-x6f26ahr 2144 12 so so RB cord-028721-x6f26ahr 2144 13 important important JJ cord-028721-x6f26ahr 2144 14 that that IN cord-028721-x6f26ahr 2144 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2144 16 is be VBZ cord-028721-x6f26ahr 2144 17 arrested arrest VBN cord-028721-x6f26ahr 2144 18 , , , cord-028721-x6f26ahr 2144 19 with with IN cord-028721-x6f26ahr 2144 20 subsequent subsequent JJ cord-028721-x6f26ahr 2144 21 azoospermia azoospermia NN cord-028721-x6f26ahr 2144 22 . . . cord-028721-x6f26ahr 2145 1 In in IN cord-028721-x6f26ahr 2145 2 some some DT cord-028721-x6f26ahr 2145 3 cases case NNS cord-028721-x6f26ahr 2145 4 , , , cord-028721-x6f26ahr 2145 5 maturation maturation NN cord-028721-x6f26ahr 2145 6 arrest arrest NN cord-028721-x6f26ahr 2145 7 is be VBZ cord-028721-x6f26ahr 2145 8 only only RB cord-028721-x6f26ahr 2145 9 partial partial JJ cord-028721-x6f26ahr 2145 10 and and CC cord-028721-x6f26ahr 2145 11 results result NNS cord-028721-x6f26ahr 2145 12 in in IN cord-028721-x6f26ahr 2145 13 severe severe JJ cord-028721-x6f26ahr 2145 14 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2145 15 . . . cord-028721-x6f26ahr 2146 1 This this DT cord-028721-x6f26ahr 2146 2 maturation maturation NN cord-028721-x6f26ahr 2146 3 arrest arrest NN cord-028721-x6f26ahr 2146 4 is be VBZ cord-028721-x6f26ahr 2146 5 observed observe VBN cord-028721-x6f26ahr 2146 6 mainly mainly RB cord-028721-x6f26ahr 2146 7 in in IN cord-028721-x6f26ahr 2146 8 primary primary JJ cord-028721-x6f26ahr 2146 9 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2146 10 and and CC cord-028721-x6f26ahr 2146 11 young young JJ cord-028721-x6f26ahr 2146 12 spermatids spermatid NNS cord-028721-x6f26ahr 2146 13 . . . cord-028721-x6f26ahr 2147 1 Primary primary JJ cord-028721-x6f26ahr 2147 2 spermatocyte spermatocyte NN cord-028721-x6f26ahr 2147 3 sloughing sloughing NN cord-028721-x6f26ahr 2147 4 may may MD cord-028721-x6f26ahr 2147 5 also also RB cord-028721-x6f26ahr 2147 6 be be VB cord-028721-x6f26ahr 2147 7 owing owe VBG cord-028721-x6f26ahr 2147 8 to to IN cord-028721-x6f26ahr 2147 9 meiotic meiotic JJ cord-028721-x6f26ahr 2147 10 anomalies anomaly NNS cord-028721-x6f26ahr 2147 11 ( ( -LRB- cord-028721-x6f26ahr 2147 12 Fig Fig NNP cord-028721-x6f26ahr 2147 13 . . . cord-028721-x6f26ahr 2147 14 12 12 CD cord-028721-x6f26ahr 2147 15 - - SYM cord-028721-x6f26ahr 2147 16 102 102 CD cord-028721-x6f26ahr 2147 17 ) ) -RRB- cord-028721-x6f26ahr 2147 18 . . . cord-028721-x6f26ahr 2148 1 The the DT cord-028721-x6f26ahr 2148 2 observation observation NN cord-028721-x6f26ahr 2148 3 of of IN cord-028721-x6f26ahr 2148 4 increased increase VBN cord-028721-x6f26ahr 2148 5 numbers number NNS cord-028721-x6f26ahr 2148 6 of of IN cord-028721-x6f26ahr 2148 7 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2148 8 arrested arrest VBN cord-028721-x6f26ahr 2148 9 in in IN cord-028721-x6f26ahr 2148 10 preleptotene preleptotene JJ cord-028721-x6f26ahr 2148 11 - - HYPH cord-028721-x6f26ahr 2148 12 leptotene leptotene NNP cord-028721-x6f26ahr 2148 13 926 926 CD cord-028721-x6f26ahr 2149 1 or or CC cord-028721-x6f26ahr 2149 2 , , , cord-028721-x6f26ahr 2149 3 more more RBR cord-028721-x6f26ahr 2149 4 frequently frequently RB cord-028721-x6f26ahr 2149 5 , , , cord-028721-x6f26ahr 2149 6 pachytene pachytene NNP cord-028721-x6f26ahr 2149 7 856 856 CD cord-028721-x6f26ahr 2149 8 suggests suggest VBZ cord-028721-x6f26ahr 2149 9 the the DT cord-028721-x6f26ahr 2149 10 diagnosis diagnosis NN cord-028721-x6f26ahr 2149 11 . . . cord-028721-x6f26ahr 2150 1 The the DT cord-028721-x6f26ahr 2150 2 lesion lesion NN cord-028721-x6f26ahr 2150 3 is be VBZ cord-028721-x6f26ahr 2150 4 always always RB cord-028721-x6f26ahr 2150 5 bilateral bilateral JJ cord-028721-x6f26ahr 2150 6 . . . cord-028721-x6f26ahr 2151 1 Spermatocytes Spermatocytes NNP cord-028721-x6f26ahr 2151 2 arrested arrest VBN cord-028721-x6f26ahr 2151 3 in in IN cord-028721-x6f26ahr 2151 4 pachytene pachytene NN cord-028721-x6f26ahr 2151 5 are be VBP cord-028721-x6f26ahr 2151 6 usually usually RB cord-028721-x6f26ahr 2151 7 increased increase VBN cord-028721-x6f26ahr 2151 8 in in IN cord-028721-x6f26ahr 2151 9 size size NN cord-028721-x6f26ahr 2151 10 and and CC cord-028721-x6f26ahr 2151 11 later later RB cord-028721-x6f26ahr 2151 12 degenerate degenerate JJ cord-028721-x6f26ahr 2151 13 . . . cord-028721-x6f26ahr 2152 1 In in IN cord-028721-x6f26ahr 2152 2 addition addition NN cord-028721-x6f26ahr 2152 3 , , , cord-028721-x6f26ahr 2152 4 some some DT cord-028721-x6f26ahr 2152 5 spermatids spermatid NNS cord-028721-x6f26ahr 2152 6 have have VBP cord-028721-x6f26ahr 2152 7 large large JJ cord-028721-x6f26ahr 2152 8 , , , cord-028721-x6f26ahr 2152 9 diploid diploid JJ cord-028721-x6f26ahr 2152 10 , , , cord-028721-x6f26ahr 2152 11 spherical spherical JJ cord-028721-x6f26ahr 2152 12 , , , cord-028721-x6f26ahr 2152 13 hyperchromatic hyperchromatic JJ cord-028721-x6f26ahr 2152 14 nuclei nucleus NNS cord-028721-x6f26ahr 2152 15 . . . cord-028721-x6f26ahr 2153 1 The the DT cord-028721-x6f26ahr 2153 2 anomaly anomaly NN cord-028721-x6f26ahr 2153 3 does do VBZ cord-028721-x6f26ahr 2153 4 not not RB cord-028721-x6f26ahr 2153 5 always always RB cord-028721-x6f26ahr 2153 6 affect affect VB cord-028721-x6f26ahr 2153 7 all all DT cord-028721-x6f26ahr 2153 8 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2153 9 , , , cord-028721-x6f26ahr 2153 10 and and CC cord-028721-x6f26ahr 2153 11 then then RB cord-028721-x6f26ahr 2153 12 a a DT cord-028721-x6f26ahr 2153 13 higher high JJR cord-028721-x6f26ahr 2153 14 number number NN cord-028721-x6f26ahr 2153 15 of of IN cord-028721-x6f26ahr 2153 16 spermatids spermatid NNS cord-028721-x6f26ahr 2153 17 are be VBP cord-028721-x6f26ahr 2153 18 produced produce VBN cord-028721-x6f26ahr 2153 19 . . . cord-028721-x6f26ahr 2154 1 856 856 CD cord-028721-x6f26ahr 2154 2 Young young JJ cord-028721-x6f26ahr 2154 3 spermatid spermatid NN cord-028721-x6f26ahr 2154 4 sloughing slough VBG cord-028721-x6f26ahr 2154 5 not not RB cord-028721-x6f26ahr 2154 6 associated associate VBN cord-028721-x6f26ahr 2154 7 with with IN cord-028721-x6f26ahr 2154 8 obstruction obstruction NN cord-028721-x6f26ahr 2154 9 may may MD cord-028721-x6f26ahr 2154 10 be be VB cord-028721-x6f26ahr 2154 11 due due JJ cord-028721-x6f26ahr 2154 12 to to IN cord-028721-x6f26ahr 2154 13 either either DT cord-028721-x6f26ahr 2154 14 meiotic meiotic JJ cord-028721-x6f26ahr 2154 15 anomalies anomaly NNS cord-028721-x6f26ahr 2154 16 or or CC cord-028721-x6f26ahr 2154 17 defective defective JJ cord-028721-x6f26ahr 2154 18 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 2154 19 . . . cord-028721-x6f26ahr 2155 1 The the DT cord-028721-x6f26ahr 2155 2 former former JJ cord-028721-x6f26ahr 2155 3 gives give VBZ cord-028721-x6f26ahr 2155 4 rises rise VBZ cord-028721-x6f26ahr 2155 5 to to IN cord-028721-x6f26ahr 2155 6 the the DT cord-028721-x6f26ahr 2155 7 appearance appearance NN cord-028721-x6f26ahr 2155 8 of of IN cord-028721-x6f26ahr 2155 9 many many JJ cord-028721-x6f26ahr 2155 10 multinucleate multinucleate NN cord-028721-x6f26ahr 2155 11 , , , cord-028721-x6f26ahr 2155 12 polyploid polyploid JJ cord-028721-x6f26ahr 2155 13 , , , cord-028721-x6f26ahr 2155 14 hyperchromatic hyperchromatic JJ cord-028721-x6f26ahr 2155 15 young young JJ cord-028721-x6f26ahr 2155 16 spermatids spermatid NNS cord-028721-x6f26ahr 2155 17 . . . cord-028721-x6f26ahr 2156 1 In in IN cord-028721-x6f26ahr 2156 2 the the DT cord-028721-x6f26ahr 2156 3 second second JJ cord-028721-x6f26ahr 2156 4 cause cause NN cord-028721-x6f26ahr 2156 5 , , , cord-028721-x6f26ahr 2156 6 young young JJ cord-028721-x6f26ahr 2156 7 spermatids spermatid NNS cord-028721-x6f26ahr 2156 8 are be VBP cord-028721-x6f26ahr 2156 9 incapable incapable JJ cord-028721-x6f26ahr 2156 10 of of IN cord-028721-x6f26ahr 2156 11 transforming transform VBG cord-028721-x6f26ahr 2156 12 into into IN cord-028721-x6f26ahr 2156 13 mature mature JJ cord-028721-x6f26ahr 2156 14 spermatids spermatid NNS cord-028721-x6f26ahr 2156 15 , , , cord-028721-x6f26ahr 2156 16 and and CC cord-028721-x6f26ahr 2156 17 only only RB cord-028721-x6f26ahr 2156 18 round round JJ cord-028721-x6f26ahr 2156 19 spermatids spermatid NNS cord-028721-x6f26ahr 2156 20 appear appear VBP cord-028721-x6f26ahr 2156 21 in in IN cord-028721-x6f26ahr 2156 22 the the DT cord-028721-x6f26ahr 2156 23 ejaculate ejaculate NN cord-028721-x6f26ahr 2156 24 . . . cord-028721-x6f26ahr 2156 25 _SP cord-028721-x6f26ahr 2157 1 Lesions lesion NNS cord-028721-x6f26ahr 2157 2 in in IN cord-028721-x6f26ahr 2157 3 the the DT cord-028721-x6f26ahr 2157 4 basal basal NN cord-028721-x6f26ahr 2157 5 and and CC cord-028721-x6f26ahr 2157 6 adluminal adluminal JJ cord-028721-x6f26ahr 2157 7 compartments compartment NNS cord-028721-x6f26ahr 2157 8 of of IN cord-028721-x6f26ahr 2157 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 2157 10 tubules tubule NNS cord-028721-x6f26ahr 2157 11 are be VBP cord-028721-x6f26ahr 2157 12 the the DT cord-028721-x6f26ahr 2157 13 most most RBS cord-028721-x6f26ahr 2157 14 frequent frequent JJ cord-028721-x6f26ahr 2157 15 histological histological JJ cord-028721-x6f26ahr 2157 16 fi fi NN cord-028721-x6f26ahr 2157 17 ndings nding NNS cord-028721-x6f26ahr 2157 18 in in IN cord-028721-x6f26ahr 2157 19 testicular testicular JJ cord-028721-x6f26ahr 2157 20 biopsies biopsy NNS cord-028721-x6f26ahr 2157 21 from from IN cord-028721-x6f26ahr 2157 22 infertile infertile JJ cord-028721-x6f26ahr 2157 23 men man NNS cord-028721-x6f26ahr 2157 24 . . . cord-028721-x6f26ahr 2158 1 These these DT cord-028721-x6f26ahr 2158 2 testes testis NNS cord-028721-x6f26ahr 2158 3 may may MD cord-028721-x6f26ahr 2158 4 be be VB cord-028721-x6f26ahr 2158 5 classifi classifi NNP cord-028721-x6f26ahr 2158 6 ed ed NN cord-028721-x6f26ahr 2158 7 into into IN cord-028721-x6f26ahr 2158 8 two two CD cord-028721-x6f26ahr 2158 9 major major JJ cord-028721-x6f26ahr 2158 10 subgroups subgroup NNS cord-028721-x6f26ahr 2158 11 : : : cord-028721-x6f26ahr 2158 12 hypospermatogenesis hypospermatogenesis NNP cord-028721-x6f26ahr 2158 13 and and CC cord-028721-x6f26ahr 2158 14 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2158 15 maturation maturation NN cord-028721-x6f26ahr 2158 16 arrest arrest NN cord-028721-x6f26ahr 2158 17 ( ( -LRB- cord-028721-x6f26ahr 2158 18 Fig Fig NNP cord-028721-x6f26ahr 2158 19 . . . cord-028721-x6f26ahr 2158 20 _SP cord-028721-x6f26ahr 2158 21 12 12 CD cord-028721-x6f26ahr 2158 22 - - SYM cord-028721-x6f26ahr 2158 23 103 103 CD cord-028721-x6f26ahr 2158 24 ) ) -RRB- cord-028721-x6f26ahr 2158 25 . . . cord-028721-x6f26ahr 2159 1 Hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2159 2 : : : cord-028721-x6f26ahr 2160 1 Types type NNS cord-028721-x6f26ahr 2160 2 and and CC cord-028721-x6f26ahr 2160 3 etiology etiology NN cord-028721-x6f26ahr 2160 4 Hypospermatogenesis Hypospermatogenesis NNP cord-028721-x6f26ahr 2160 5 is be VBZ cord-028721-x6f26ahr 2160 6 defi defi NNP cord-028721-x6f26ahr 2160 7 ned ned NNP cord-028721-x6f26ahr 2160 8 as as IN cord-028721-x6f26ahr 2160 9 a a DT cord-028721-x6f26ahr 2160 10 reduced reduce VBN cord-028721-x6f26ahr 2160 11 number number NN cord-028721-x6f26ahr 2160 12 of of IN cord-028721-x6f26ahr 2160 13 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2160 14 and and CC cord-028721-x6f26ahr 2160 15 primary primary JJ cord-028721-x6f26ahr 2160 16 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2160 17 , , , cord-028721-x6f26ahr 2160 18 with with IN cord-028721-x6f26ahr 2160 19 primary primary JJ cord-028721-x6f26ahr 2160 20 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2160 21 outnumbering outnumber VBG cord-028721-x6f26ahr 2160 22 the the DT cord-028721-x6f26ahr 2160 23 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2160 24 . . . cord-028721-x6f26ahr 2161 1 Most Most JJS cord-028721-x6f26ahr 2161 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 2161 3 tubules tubule NNS cord-028721-x6f26ahr 2161 4 contain contain VBP cord-028721-x6f26ahr 2161 5 few few JJ cord-028721-x6f26ahr 2161 6 spermatids spermatid NNS cord-028721-x6f26ahr 2161 7 . . . cord-028721-x6f26ahr 2162 1 About about IN cord-028721-x6f26ahr 2162 2 8 8 CD cord-028721-x6f26ahr 2162 3 % % NN cord-028721-x6f26ahr 2162 4 of of IN cord-028721-x6f26ahr 2162 5 patients patient NNS cord-028721-x6f26ahr 2162 6 with with IN cord-028721-x6f26ahr 2162 7 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2162 8 have have VBP cord-028721-x6f26ahr 2162 9 focal focal JJ cord-028721-x6f26ahr 2162 10 tubular tubular JJ cord-028721-x6f26ahr 2162 11 hyalinization hyalinization NN cord-028721-x6f26ahr 2162 12 . . . cord-028721-x6f26ahr 2163 1 937 937 CD cord-028721-x6f26ahr 2164 1 Two two CD cord-028721-x6f26ahr 2164 2 variants variant NNS cord-028721-x6f26ahr 2164 3 of of IN cord-028721-x6f26ahr 2164 4 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2164 5 have have VBP cord-028721-x6f26ahr 2164 6 been be VBN cord-028721-x6f26ahr 2164 7 quantitatively quantitatively RB cord-028721-x6f26ahr 2164 8 distinguished distinguished JJ cord-028721-x6f26ahr 2164 9 : : : cord-028721-x6f26ahr 2164 10 pure pure JJ cord-028721-x6f26ahr 2164 11 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2164 12 , , , cord-028721-x6f26ahr 2164 13 and and CC cord-028721-x6f26ahr 2164 14 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2164 15 associated associate VBN cord-028721-x6f26ahr 2164 16 with with IN cord-028721-x6f26ahr 2164 17 sloughing slough VBG cord-028721-x6f26ahr 2164 18 of of IN cord-028721-x6f26ahr 2164 19 primary primary JJ cord-028721-x6f26ahr 2164 20 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2164 21 . . . cord-028721-x6f26ahr 2165 1 Pure pure JJ cord-028721-x6f26ahr 2165 2 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2165 3 is be VBZ cord-028721-x6f26ahr 2165 4 defi defi NNP cord-028721-x6f26ahr 2165 5 ned ned NNP cord-028721-x6f26ahr 2165 6 as as IN cord-028721-x6f26ahr 2165 7 a a DT cord-028721-x6f26ahr 2165 8 proportionate proportionate JJ cord-028721-x6f26ahr 2165 9 decrease decrease NN cord-028721-x6f26ahr 2165 10 in in IN cord-028721-x6f26ahr 2165 11 the the DT cord-028721-x6f26ahr 2165 12 number number NN cord-028721-x6f26ahr 2165 13 of of IN cord-028721-x6f26ahr 2165 14 all all DT cord-028721-x6f26ahr 2165 15 types type NNS cord-028721-x6f26ahr 2165 16 of of IN cord-028721-x6f26ahr 2165 17 germ germ NN cord-028721-x6f26ahr 2165 18 cell cell NN cord-028721-x6f26ahr 2165 19 . . . cord-028721-x6f26ahr 2166 1 The the DT cord-028721-x6f26ahr 2166 2 number number NN cord-028721-x6f26ahr 2166 3 of of IN cord-028721-x6f26ahr 2166 4 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2166 5 per per IN cord-028721-x6f26ahr 2166 6 cross cross JJ cord-028721-x6f26ahr 2166 7 - - JJ cord-028721-x6f26ahr 2166 8 sectioned sectioned JJ cord-028721-x6f26ahr 2166 9 tubule tubule NN cord-028721-x6f26ahr 2166 10 is be VBZ cord-028721-x6f26ahr 2166 11 less less JJR cord-028721-x6f26ahr 2166 12 than than IN cord-028721-x6f26ahr 2166 13 17 17 CD cord-028721-x6f26ahr 2166 14 and and CC cord-028721-x6f26ahr 2166 15 usually usually RB cord-028721-x6f26ahr 2166 16 more more JJR cord-028721-x6f26ahr 2166 17 than than IN cord-028721-x6f26ahr 2166 18 10 10 CD cord-028721-x6f26ahr 2166 19 . . . cord-028721-x6f26ahr 2167 1 The the DT cord-028721-x6f26ahr 2167 2 number number NN cord-028721-x6f26ahr 2167 3 of of IN cord-028721-x6f26ahr 2167 4 primary primary JJ cord-028721-x6f26ahr 2167 5 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2167 6 is be VBZ cord-028721-x6f26ahr 2167 7 equal equal JJ cord-028721-x6f26ahr 2167 8 to to IN cord-028721-x6f26ahr 2167 9 or or CC cord-028721-x6f26ahr 2167 10 higher high JJR cord-028721-x6f26ahr 2167 11 than than IN cord-028721-x6f26ahr 2167 12 that that DT cord-028721-x6f26ahr 2167 13 of of IN cord-028721-x6f26ahr 2167 14 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2167 15 . . . cord-028721-x6f26ahr 2168 1 The the DT cord-028721-x6f26ahr 2168 2 number number NN cord-028721-x6f26ahr 2168 3 of of IN cord-028721-x6f26ahr 2168 4 round round JJ cord-028721-x6f26ahr 2168 5 spermatids spermatid NNS cord-028721-x6f26ahr 2168 6 is be VBZ cord-028721-x6f26ahr 2168 7 higher high JJR cord-028721-x6f26ahr 2168 8 than than IN cord-028721-x6f26ahr 2168 9 that that DT cord-028721-x6f26ahr 2168 10 of of IN cord-028721-x6f26ahr 2168 11 primary primary JJ cord-028721-x6f26ahr 2168 12 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2168 13 , , , cord-028721-x6f26ahr 2168 14 and and CC cord-028721-x6f26ahr 2168 15 the the DT cord-028721-x6f26ahr 2168 16 number number NN cord-028721-x6f26ahr 2168 17 of of IN cord-028721-x6f26ahr 2168 18 elongated elongated JJ cord-028721-x6f26ahr 2168 19 spermatids spermatid NNS cord-028721-x6f26ahr 2168 20 is be VBZ cord-028721-x6f26ahr 2168 21 similar similar JJ cord-028721-x6f26ahr 2168 22 to to IN cord-028721-x6f26ahr 2168 23 that that DT cord-028721-x6f26ahr 2168 24 of of IN cord-028721-x6f26ahr 2168 25 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2169 1 ( ( -LRB- cord-028721-x6f26ahr 2169 2 Fig Fig NNP cord-028721-x6f26ahr 2169 3 . . . cord-028721-x6f26ahr 2169 4 _SP cord-028721-x6f26ahr 2169 5 12 12 CD cord-028721-x6f26ahr 2169 6 - - SYM cord-028721-x6f26ahr 2169 7 104 104 CD cord-028721-x6f26ahr 2169 8 ) ) -RRB- cord-028721-x6f26ahr 2169 9 . . . cord-028721-x6f26ahr 2170 1 Hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2170 2 associated associate VBN cord-028721-x6f26ahr 2170 3 with with IN cord-028721-x6f26ahr 2170 4 primary primary JJ cord-028721-x6f26ahr 2170 5 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2170 6 sloughing sloughing NN cord-028721-x6f26ahr 2170 7 is be VBZ cord-028721-x6f26ahr 2170 8 characterized characterize VBN cord-028721-x6f26ahr 2170 9 by by IN cord-028721-x6f26ahr 2170 10 two two CD cord-028721-x6f26ahr 2170 11 features feature NNS cord-028721-x6f26ahr 2170 12 : : : cord-028721-x6f26ahr 2170 13 low low JJ cord-028721-x6f26ahr 2170 14 numbers number NNS cord-028721-x6f26ahr 2170 15 of of IN cord-028721-x6f26ahr 2170 16 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2170 17 and and CC cord-028721-x6f26ahr 2170 18 primary primary JJ cord-028721-x6f26ahr 2170 19 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2170 20 ( ( -LRB- cord-028721-x6f26ahr 2170 21 with with IN cord-028721-x6f26ahr 2170 22 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2170 23 more more RBR cord-028721-x6f26ahr 2170 24 numerous numerous JJ cord-028721-x6f26ahr 2170 25 than than IN cord-028721-x6f26ahr 2170 26 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2170 27 ) ) -RRB- cord-028721-x6f26ahr 2170 28 , , , cord-028721-x6f26ahr 2170 29 and and CC cord-028721-x6f26ahr 2170 30 degeneration degeneration NN cord-028721-x6f26ahr 2170 31 and and CC cord-028721-x6f26ahr 2170 32 sloughing sloughing NN cord-028721-x6f26ahr 2170 33 of of IN cord-028721-x6f26ahr 2170 34 many many JJ cord-028721-x6f26ahr 2170 35 primary primary JJ cord-028721-x6f26ahr 2170 36 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2170 37 . . . cord-028721-x6f26ahr 2171 1 The the DT cord-028721-x6f26ahr 2171 2 remaining remain VBG cord-028721-x6f26ahr 2171 3 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2171 4 give give VBP cord-028721-x6f26ahr 2171 5 rise rise NN cord-028721-x6f26ahr 2171 6 to to IN cord-028721-x6f26ahr 2171 7 the the DT cord-028721-x6f26ahr 2171 8 few few JJ cord-028721-x6f26ahr 2171 9 spermatids spermatid NNS cord-028721-x6f26ahr 2171 10 observed observe VBN cord-028721-x6f26ahr 2171 11 in in IN cord-028721-x6f26ahr 2171 12 the the DT cord-028721-x6f26ahr 2171 13 tubules tubule NNS cord-028721-x6f26ahr 2171 14 ( ( -LRB- cord-028721-x6f26ahr 2171 15 Fig Fig NNP cord-028721-x6f26ahr 2171 16 . . . cord-028721-x6f26ahr 2171 17 12 12 CD cord-028721-x6f26ahr 2171 18 - - SYM cord-028721-x6f26ahr 2171 19 105 105 CD cord-028721-x6f26ahr 2171 20 ) ) -RRB- cord-028721-x6f26ahr 2171 21 . . . cord-028721-x6f26ahr 2172 1 Etiology etiology NN cord-028721-x6f26ahr 2172 2 of of IN cord-028721-x6f26ahr 2172 3 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2172 4 . . . cord-028721-x6f26ahr 2173 1 Hypospermatogenesis Hypospermatogenesis NNP cord-028721-x6f26ahr 2173 2 may may MD cord-028721-x6f26ahr 2173 3 result result VB cord-028721-x6f26ahr 2173 4 from from IN cord-028721-x6f26ahr 2173 5 hormonal hormonal JJ cord-028721-x6f26ahr 2173 6 dysfunction dysfunction NN cord-028721-x6f26ahr 2173 7 , , , cord-028721-x6f26ahr 2173 8 congenital congenital JJ cord-028721-x6f26ahr 2173 9 germ germ NN cord-028721-x6f26ahr 2173 10 cell cell NN cord-028721-x6f26ahr 2173 11 defi defi NN cord-028721-x6f26ahr 2173 12 ciency ciency NNP cord-028721-x6f26ahr 2173 13 , , , cord-028721-x6f26ahr 2173 14 Sertoli sertoli JJ cord-028721-x6f26ahr 2173 15 cell cell NN cord-028721-x6f26ahr 2173 16 dysfunction dysfunction NN cord-028721-x6f26ahr 2173 17 , , , cord-028721-x6f26ahr 2173 18 Leydig Leydig NNP cord-028721-x6f26ahr 2173 19 cell cell NN cord-028721-x6f26ahr 2173 20 dysfunction dysfunction NN cord-028721-x6f26ahr 2173 21 , , , cord-028721-x6f26ahr 2173 22 Infertility Infertility NNP cord-028721-x6f26ahr 2173 23 androgen androgen NN cord-028721-x6f26ahr 2173 24 insensitivity insensitivity NN cord-028721-x6f26ahr 2173 25 , , , cord-028721-x6f26ahr 2173 26 exposure exposure NN cord-028721-x6f26ahr 2173 27 to to IN cord-028721-x6f26ahr 2173 28 chemical chemical JJ cord-028721-x6f26ahr 2173 29 or or CC cord-028721-x6f26ahr 2173 30 physical physical JJ cord-028721-x6f26ahr 2173 31 agents agent NNS cord-028721-x6f26ahr 2173 32 , , , cord-028721-x6f26ahr 2173 33 and and CC cord-028721-x6f26ahr 2173 34 vascular vascular JJ cord-028721-x6f26ahr 2173 35 malfunction malfunction NN cord-028721-x6f26ahr 2173 36 . . . cord-028721-x6f26ahr 2174 1 Hormonal hormonal JJ cord-028721-x6f26ahr 2174 2 dysregulation dysregulation NN cord-028721-x6f26ahr 2174 3 . . . cord-028721-x6f26ahr 2175 1 Although although IN cord-028721-x6f26ahr 2175 2 complete complete JJ cord-028721-x6f26ahr 2175 3 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2175 4 may may MD cord-028721-x6f26ahr 2175 5 be be VB cord-028721-x6f26ahr 2175 6 observed observe VBN cord-028721-x6f26ahr 2175 7 in in IN cord-028721-x6f26ahr 2175 8 men man NNS cord-028721-x6f26ahr 2175 9 with with IN cord-028721-x6f26ahr 2175 10 low low JJ cord-028721-x6f26ahr 2175 11 levels level NNS cord-028721-x6f26ahr 2175 12 of of IN cord-028721-x6f26ahr 2175 13 FSH fsh NN cord-028721-x6f26ahr 2175 14 and and CC cord-028721-x6f26ahr 2175 15 LH LH NNP cord-028721-x6f26ahr 2175 16 , , , cord-028721-x6f26ahr 2175 17 the the DT cord-028721-x6f26ahr 2175 18 production production NN cord-028721-x6f26ahr 2175 19 of of IN cord-028721-x6f26ahr 2175 20 a a DT cord-028721-x6f26ahr 2175 21 normal normal JJ cord-028721-x6f26ahr 2175 22 number number NN cord-028721-x6f26ahr 2175 23 of of IN cord-028721-x6f26ahr 2175 24 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2175 25 requires require VBZ cord-028721-x6f26ahr 2175 26 normal normal JJ cord-028721-x6f26ahr 2175 27 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 2175 28 levels level NNS cord-028721-x6f26ahr 2175 29 . . . cord-028721-x6f26ahr 2176 1 Hypospermatogenesis Hypospermatogenesis NNP cord-028721-x6f26ahr 2176 2 has have VBZ cord-028721-x6f26ahr 2176 3 been be VBN cord-028721-x6f26ahr 2176 4 reported report VBN cord-028721-x6f26ahr 2176 5 in in IN cord-028721-x6f26ahr 2176 6 patients patient NNS cord-028721-x6f26ahr 2176 7 with with IN cord-028721-x6f26ahr 2176 8 abnormal abnormal JJ cord-028721-x6f26ahr 2176 9 pulsatile pulsatile JJ cord-028721-x6f26ahr 2176 10 secretion secretion NN cord-028721-x6f26ahr 2176 11 of of IN cord-028721-x6f26ahr 2176 12 FSH fsh NN cord-028721-x6f26ahr 2176 13 and and CC cord-028721-x6f26ahr 2176 14 LH LH NNP cord-028721-x6f26ahr 2176 15 , , , cord-028721-x6f26ahr 2176 16 938 938 CD cord-028721-x6f26ahr 2176 17 low low JJ cord-028721-x6f26ahr 2176 18 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2176 19 secretion secretion NN cord-028721-x6f26ahr 2176 20 , , , cord-028721-x6f26ahr 2176 21 939 939 CD cord-028721-x6f26ahr 2176 22 biologically biologically RB cord-028721-x6f26ahr 2176 23 inactive inactive JJ cord-028721-x6f26ahr 2176 24 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 2176 25 , , , cord-028721-x6f26ahr 2176 26 mutation mutation NN cord-028721-x6f26ahr 2176 27 in in IN cord-028721-x6f26ahr 2176 28 the the DT cord-028721-x6f26ahr 2176 29 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2176 30 β β NNP cord-028721-x6f26ahr 2176 31 subunit subunit NN cord-028721-x6f26ahr 2176 32 , , , cord-028721-x6f26ahr 2176 33 940 940 CD cord-028721-x6f26ahr 2176 34 inactivating inactivate VBG cord-028721-x6f26ahr 2176 35 mutation mutation NN cord-028721-x6f26ahr 2176 36 of of IN cord-028721-x6f26ahr 2176 37 FSH FSH NNP cord-028721-x6f26ahr 2176 38 receptor receptor NN cord-028721-x6f26ahr 2176 39 gene gene NN cord-028721-x6f26ahr 2176 40 , , , cord-028721-x6f26ahr 2176 41 941 941 CD cord-028721-x6f26ahr 2176 42 hyperprolactinemia hyperprolactinemia NN cord-028721-x6f26ahr 2176 43 , , , cord-028721-x6f26ahr 2176 44 and and CC cord-028721-x6f26ahr 2176 45 adrenal adrenal JJ cord-028721-x6f26ahr 2176 46 and and CC cord-028721-x6f26ahr 2176 47 thyroid thyroid NN cord-028721-x6f26ahr 2176 48 dysfunction dysfunction NN cord-028721-x6f26ahr 2176 49 ( ( -LRB- cord-028721-x6f26ahr 2176 50 see see VB cord-028721-x6f26ahr 2176 51 discussion discussion NN cord-028721-x6f26ahr 2176 52 on on IN cord-028721-x6f26ahr 2176 53 hypogonadisms hypogonadisms NNP cord-028721-x6f26ahr 2176 54 secondary secondary JJ cord-028721-x6f26ahr 2176 55 to to IN cord-028721-x6f26ahr 2176 56 endocrine endocrine JJ cord-028721-x6f26ahr 2176 57 gland gland NN cord-028721-x6f26ahr 2176 58 dysfunction dysfunction NN cord-028721-x6f26ahr 2176 59 in in IN cord-028721-x6f26ahr 2176 60 this this DT cord-028721-x6f26ahr 2176 61 chapter chapter NN cord-028721-x6f26ahr 2176 62 ) ) -RRB- cord-028721-x6f26ahr 2176 63 . . . cord-028721-x6f26ahr 2177 1 Congenital congenital JJ cord-028721-x6f26ahr 2177 2 germ germ NN cord-028721-x6f26ahr 2177 3 cell cell NN cord-028721-x6f26ahr 2177 4 defi defi NNP cord-028721-x6f26ahr 2177 5 ciency ciency NNP cord-028721-x6f26ahr 2177 6 . . . cord-028721-x6f26ahr 2178 1 Biopsy biopsy NN cord-028721-x6f26ahr 2178 2 of of IN cord-028721-x6f26ahr 2178 3 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 2178 4 patients patient NNS cord-028721-x6f26ahr 2178 5 after after IN cord-028721-x6f26ahr 2178 6 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 2178 7 reveals reveal VBZ cord-028721-x6f26ahr 2178 8 that that IN cord-028721-x6f26ahr 2178 9 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2178 10 proliferation proliferation NN cord-028721-x6f26ahr 2178 11 is be VBZ cord-028721-x6f26ahr 2178 12 decreased decrease VBN cord-028721-x6f26ahr 2178 13 and and CC cord-028721-x6f26ahr 2178 14 germ germ NN cord-028721-x6f26ahr 2178 15 cell cell NN cord-028721-x6f26ahr 2178 16 development development NN cord-028721-x6f26ahr 2178 17 is be VBZ cord-028721-x6f26ahr 2178 18 insufficient insufficient JJ cord-028721-x6f26ahr 2178 19 in in IN cord-028721-x6f26ahr 2178 20 adulthood adulthood NN cord-028721-x6f26ahr 2178 21 even even RB cord-028721-x6f26ahr 2178 22 if if IN cord-028721-x6f26ahr 2178 23 the the DT cord-028721-x6f26ahr 2178 24 number number NN cord-028721-x6f26ahr 2178 25 of of IN cord-028721-x6f26ahr 2178 26 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2178 27 was be VBD cord-028721-x6f26ahr 2178 28 normal normal JJ cord-028721-x6f26ahr 2178 29 in in IN cord-028721-x6f26ahr 2178 30 infancy infancy NN cord-028721-x6f26ahr 2178 31 . . . cord-028721-x6f26ahr 2179 1 Is be VBZ cord-028721-x6f26ahr 2179 2 it -PRON- PRP cord-028721-x6f26ahr 2179 3 likely likely JJ cord-028721-x6f26ahr 2179 4 that that IN cord-028721-x6f26ahr 2179 5 this this DT cord-028721-x6f26ahr 2179 6 poorly poorly RB cord-028721-x6f26ahr 2179 7 understood understand VBN cord-028721-x6f26ahr 2179 8 primary primary JJ cord-028721-x6f26ahr 2179 9 anomaly anomaly NN cord-028721-x6f26ahr 2179 10 of of IN cord-028721-x6f26ahr 2179 11 germ germ NN cord-028721-x6f26ahr 2179 12 cells cell NNS cord-028721-x6f26ahr 2179 13 is be VBZ cord-028721-x6f26ahr 2179 14 present present JJ cord-028721-x6f26ahr 2179 15 in in IN cord-028721-x6f26ahr 2179 16 some some DT cord-028721-x6f26ahr 2179 17 cases case NNS cord-028721-x6f26ahr 2179 18 of of IN cord-028721-x6f26ahr 2179 19 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2179 20 . . . cord-028721-x6f26ahr 2180 1 Sertoli sertoli JJ cord-028721-x6f26ahr 2180 2 cell cell NN cord-028721-x6f26ahr 2180 3 dysfunction dysfunction NN cord-028721-x6f26ahr 2180 4 . . . cord-028721-x6f26ahr 2181 1 For for IN cord-028721-x6f26ahr 2181 2 many many JJ cord-028721-x6f26ahr 2181 3 years year NNS cord-028721-x6f26ahr 2181 4 , , , cord-028721-x6f26ahr 2181 5 primary primary JJ cord-028721-x6f26ahr 2181 6 germ germ NN cord-028721-x6f26ahr 2181 7 cell cell NN cord-028721-x6f26ahr 2181 8 defi defi NNP cord-028721-x6f26ahr 2181 9 ciency ciency NNP cord-028721-x6f26ahr 2181 10 was be VBD cord-028721-x6f26ahr 2181 11 considered consider VBN cord-028721-x6f26ahr 2181 12 the the DT cord-028721-x6f26ahr 2181 13 most most RBS cord-028721-x6f26ahr 2181 14 common common JJ cord-028721-x6f26ahr 2181 15 cause cause NN cord-028721-x6f26ahr 2181 16 of of IN cord-028721-x6f26ahr 2181 17 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2181 18 ; ; : cord-028721-x6f26ahr 2181 19 today today NN cord-028721-x6f26ahr 2181 20 , , , cord-028721-x6f26ahr 2181 21 it -PRON- PRP cord-028721-x6f26ahr 2181 22 is be VBZ cord-028721-x6f26ahr 2181 23 known know VBN cord-028721-x6f26ahr 2181 24 that that IN cord-028721-x6f26ahr 2181 25 Sertoli sertoli JJ cord-028721-x6f26ahr 2181 26 cell cell NN cord-028721-x6f26ahr 2181 27 failure failure NN cord-028721-x6f26ahr 2181 28 is be VBZ cord-028721-x6f26ahr 2181 29 the the DT cord-028721-x6f26ahr 2181 30 cause cause NN cord-028721-x6f26ahr 2181 31 of of IN cord-028721-x6f26ahr 2181 32 many many JJ cord-028721-x6f26ahr 2181 33 cases case NNS cord-028721-x6f26ahr 2181 34 of of IN cord-028721-x6f26ahr 2181 35 germ germ NN cord-028721-x6f26ahr 2181 36 cell cell NN cord-028721-x6f26ahr 2181 37 defi defi NNP cord-028721-x6f26ahr 2181 38 ciency ciency NNP cord-028721-x6f26ahr 2181 39 . . . cord-028721-x6f26ahr 2182 1 This this DT cord-028721-x6f26ahr 2182 2 conclusion conclusion NN cord-028721-x6f26ahr 2182 3 is be VBZ cord-028721-x6f26ahr 2182 4 based base VBN cord-028721-x6f26ahr 2182 5 on on IN cord-028721-x6f26ahr 2182 6 several several JJ cord-028721-x6f26ahr 2182 7 fi fi NN cord-028721-x6f26ahr 2182 8 ndings nding NNS cord-028721-x6f26ahr 2182 9 . . . cord-028721-x6f26ahr 2183 1 Sertoli sertoli JJ cord-028721-x6f26ahr 2183 2 cells cell NNS cord-028721-x6f26ahr 2183 3 in in IN cord-028721-x6f26ahr 2183 4 many many JJ cord-028721-x6f26ahr 2183 5 infertile infertile JJ cord-028721-x6f26ahr 2183 6 patients patient NNS cord-028721-x6f26ahr 2183 7 are be VBP cord-028721-x6f26ahr 2183 8 markedly markedly RB cord-028721-x6f26ahr 2183 9 abnormal abnormal JJ cord-028721-x6f26ahr 2183 10 , , , cord-028721-x6f26ahr 2183 11 with with IN cord-028721-x6f26ahr 2183 12 an an DT cord-028721-x6f26ahr 2183 13 increase increase NN cord-028721-x6f26ahr 2183 14 in in IN cord-028721-x6f26ahr 2183 15 the the DT cord-028721-x6f26ahr 2183 16 number number NN cord-028721-x6f26ahr 2183 17 of of IN cord-028721-x6f26ahr 2183 18 glycogen glycogen NN cord-028721-x6f26ahr 2183 19 granules granule NNS cord-028721-x6f26ahr 2183 20 942 942 CD cord-028721-x6f26ahr 2183 21 and and CC cord-028721-x6f26ahr 2183 22 acid acid JJ cord-028721-x6f26ahr 2183 23 phosphatase phosphatase NN cord-028721-x6f26ahr 2183 24 activity activity NN cord-028721-x6f26ahr 2183 25 ; ; : cord-028721-x6f26ahr 2183 26 884 884 CD cord-028721-x6f26ahr 2183 27 a a DT cord-028721-x6f26ahr 2183 28 decrease decrease NN cord-028721-x6f26ahr 2183 29 in in IN cord-028721-x6f26ahr 2183 30 the the DT cord-028721-x6f26ahr 2183 31 number number NN cord-028721-x6f26ahr 2183 32 of of IN cord-028721-x6f26ahr 2183 33 lipid lipid NN cord-028721-x6f26ahr 2183 34 droplets droplet NNS cord-028721-x6f26ahr 2183 35 ; ; : cord-028721-x6f26ahr 2183 36 and and CC cord-028721-x6f26ahr 2183 37 alterations alteration NNS cord-028721-x6f26ahr 2183 38 in in IN cord-028721-x6f26ahr 2183 39 the the DT cord-028721-x6f26ahr 2183 40 cytoskeleton cytoskeleton NN cord-028721-x6f26ahr 2183 41 , , , cord-028721-x6f26ahr 2183 42 943 943 CD cord-028721-x6f26ahr 2183 43 the the DT cord-028721-x6f26ahr 2183 44 nucleus nucleus NN cord-028721-x6f26ahr 2183 45 , , , cord-028721-x6f26ahr 2183 46 944 944 CD cord-028721-x6f26ahr 2183 47 and and CC cord-028721-x6f26ahr 2183 48 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2183 49 organelles organelle NNS cord-028721-x6f26ahr 2183 50 . . . cord-028721-x6f26ahr 2184 1 945 945 CD cord-028721-x6f26ahr 2185 1 In in IN cord-028721-x6f26ahr 2185 2 some some DT cord-028721-x6f26ahr 2185 3 cases case NNS cord-028721-x6f26ahr 2185 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 2185 5 cells cell NNS cord-028721-x6f26ahr 2185 6 have have VBP cord-028721-x6f26ahr 2185 7 abnormal abnormal JJ cord-028721-x6f26ahr 2185 8 maturation maturation NN cord-028721-x6f26ahr 2185 9 , , , cord-028721-x6f26ahr 2185 10 with with IN cord-028721-x6f26ahr 2185 11 elongated elongated JJ cord-028721-x6f26ahr 2185 12 nuclei nucleus NNS cord-028721-x6f26ahr 2185 13 containing contain VBG cord-028721-x6f26ahr 2185 14 coarse coarse RB cord-028721-x6f26ahr 2185 15 clumped clumped JJ cord-028721-x6f26ahr 2185 16 chromatin chromatin NN cord-028721-x6f26ahr 2185 17 instead instead RB cord-028721-x6f26ahr 2185 18 of of IN cord-028721-x6f26ahr 2185 19 triangular triangular JJ cord-028721-x6f26ahr 2185 20 - - HYPH cord-028721-x6f26ahr 2185 21 shaped shaped JJ cord-028721-x6f26ahr 2185 22 nuclei nucleus NNS cord-028721-x6f26ahr 2185 23 with with IN cord-028721-x6f26ahr 2185 24 pale pale JJ cord-028721-x6f26ahr 2185 25 chromatin chromatin NN cord-028721-x6f26ahr 2185 26 . . . cord-028721-x6f26ahr 2186 1 Anomalies anomaly NNS cord-028721-x6f26ahr 2186 2 in in IN cord-028721-x6f26ahr 2186 3 Sertoli sertoli JJ cord-028721-x6f26ahr 2186 4 cell cell NN cord-028721-x6f26ahr 2186 5 FSH fsh NN cord-028721-x6f26ahr 2186 6 receptors receptor NNS cord-028721-x6f26ahr 2186 7 may may MD cord-028721-x6f26ahr 2186 8 be be VB cord-028721-x6f26ahr 2186 9 present present JJ cord-028721-x6f26ahr 2186 10 in in IN cord-028721-x6f26ahr 2186 11 idiopathic idiopathic JJ cord-028721-x6f26ahr 2186 12 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2186 13 associated associate VBN cord-028721-x6f26ahr 2186 14 with with IN cord-028721-x6f26ahr 2186 15 elevated elevated JJ cord-028721-x6f26ahr 2186 16 levels level NNS cord-028721-x6f26ahr 2186 17 of of IN cord-028721-x6f26ahr 2186 18 FSH fsh NN cord-028721-x6f26ahr 2186 19 . . . cord-028721-x6f26ahr 2187 1 946 946 CD cord-028721-x6f26ahr 2188 1 Serum serum NN cord-028721-x6f26ahr 2188 2 inhibin inhibin NN cord-028721-x6f26ahr 2188 3 B B NNP cord-028721-x6f26ahr 2188 4 concentration concentration NN cord-028721-x6f26ahr 2188 5 may may MD cord-028721-x6f26ahr 2188 6 be be VB cord-028721-x6f26ahr 2188 7 used use VBN cord-028721-x6f26ahr 2188 8 as as IN cord-028721-x6f26ahr 2188 9 a a DT cord-028721-x6f26ahr 2188 10 marker marker NN cord-028721-x6f26ahr 2188 11 to to TO cord-028721-x6f26ahr 2188 12 estimate estimate VB cord-028721-x6f26ahr 2188 13 Sertoli Sertoli NNP cord-028721-x6f26ahr 2188 14 cell cell NN cord-028721-x6f26ahr 2188 15 function function NN cord-028721-x6f26ahr 2188 16 . . . cord-028721-x6f26ahr 2189 1 947 947 CD cord-028721-x6f26ahr 2189 2 Leydig Leydig NNP cord-028721-x6f26ahr 2189 3 cell cell NN cord-028721-x6f26ahr 2189 4 dysfunction dysfunction NN cord-028721-x6f26ahr 2189 5 . . . cord-028721-x6f26ahr 2190 1 Testosterone testosterone NN cord-028721-x6f26ahr 2190 2 synthesis synthesis NN cord-028721-x6f26ahr 2190 3 by by IN cord-028721-x6f26ahr 2190 4 Leydig leydig NN cord-028721-x6f26ahr 2190 5 cells cell NNS cord-028721-x6f26ahr 2190 6 is be VBZ cord-028721-x6f26ahr 2190 7 necessary necessary JJ cord-028721-x6f26ahr 2190 8 for for IN cord-028721-x6f26ahr 2190 9 normal normal JJ cord-028721-x6f26ahr 2190 10 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2190 11 , , , cord-028721-x6f26ahr 2190 12 948 948 CD cord-028721-x6f26ahr 2190 13 and and CC cord-028721-x6f26ahr 2190 14 abnormal abnormal JJ cord-028721-x6f26ahr 2190 15 Leydig Leydig NNP cord-028721-x6f26ahr 2190 16 cell cell NN cord-028721-x6f26ahr 2190 17 function function NN cord-028721-x6f26ahr 2190 18 is be VBZ cord-028721-x6f26ahr 2190 19 a a DT cord-028721-x6f26ahr 2190 20 frequent frequent JJ cord-028721-x6f26ahr 2190 21 fi fi NN cord-028721-x6f26ahr 2190 22 nding nding NN cord-028721-x6f26ahr 2190 23 in in IN cord-028721-x6f26ahr 2190 24 idiopathic idiopathic JJ cord-028721-x6f26ahr 2190 25 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2190 26 . . . cord-028721-x6f26ahr 2191 1 [ [ -LRB- cord-028721-x6f26ahr 2191 2 949 949 CD cord-028721-x6f26ahr 2191 3 ] ] -RRB- cord-028721-x6f26ahr 2191 4 [ [ -LRB- cord-028721-x6f26ahr 2191 5 950 950 CD cord-028721-x6f26ahr 2191 6 ] ] -RRB- cord-028721-x6f26ahr 2191 7 [ [ -LRB- cord-028721-x6f26ahr 2191 8 951 951 CD cord-028721-x6f26ahr 2191 9 ] ] -RRB- cord-028721-x6f26ahr 2192 1 Leydig leydig NN cord-028721-x6f26ahr 2192 2 cell cell NN cord-028721-x6f26ahr 2192 3 dysfunction dysfunction NN cord-028721-x6f26ahr 2192 4 should should MD cord-028721-x6f26ahr 2192 5 be be VB cord-028721-x6f26ahr 2192 6 suspected suspect VBN cord-028721-x6f26ahr 2192 7 when when WRB cord-028721-x6f26ahr 2192 8 the the DT cord-028721-x6f26ahr 2192 9 cells cell NNS cord-028721-x6f26ahr 2192 10 appear appear VBP cord-028721-x6f26ahr 2192 11 diffusely diffusely RB cord-028721-x6f26ahr 2192 12 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 2192 13 . . . cord-028721-x6f26ahr 2193 1 Patients patient NNS cord-028721-x6f26ahr 2193 2 have have VBP cord-028721-x6f26ahr 2193 3 elevated elevate VBN cord-028721-x6f26ahr 2193 4 serum serum NN cord-028721-x6f26ahr 2193 5 LH lh NN cord-028721-x6f26ahr 2193 6 level level NN cord-028721-x6f26ahr 2193 7 with with IN cord-028721-x6f26ahr 2193 8 depletion depletion NN cord-028721-x6f26ahr 2193 9 of of IN cord-028721-x6f26ahr 2193 10 rapid rapid JJ cord-028721-x6f26ahr 2193 11 - - HYPH cord-028721-x6f26ahr 2193 12 release release NN cord-028721-x6f26ahr 2193 13 testosterone testosterone NN cord-028721-x6f26ahr 2193 14 , , , cord-028721-x6f26ahr 2193 15 revealing reveal VBG cord-028721-x6f26ahr 2193 16 a a DT cord-028721-x6f26ahr 2193 17 lack lack NN cord-028721-x6f26ahr 2193 18 of of IN cord-028721-x6f26ahr 2193 19 early early JJ cord-028721-x6f26ahr 2193 20 response response NN cord-028721-x6f26ahr 2193 21 of of IN cord-028721-x6f26ahr 2193 22 Leydig Leydig NNP cord-028721-x6f26ahr 2193 23 cells cell NNS cord-028721-x6f26ahr 2193 24 to to IN cord-028721-x6f26ahr 2193 25 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2193 26 - - HYPH cord-028721-x6f26ahr 2193 27 releasing release VBG cord-028721-x6f26ahr 2193 28 hormone hormone NN cord-028721-x6f26ahr 2193 29 stimulation stimulation NN cord-028721-x6f26ahr 2193 30 . . . cord-028721-x6f26ahr 2194 1 The the DT cord-028721-x6f26ahr 2194 2 ratio ratio NN cord-028721-x6f26ahr 2194 3 of of IN cord-028721-x6f26ahr 2194 4 testosterone testosterone NN cord-028721-x6f26ahr 2194 5 to to IN cord-028721-x6f26ahr 2194 6 LH LH NNP cord-028721-x6f26ahr 2194 7 in in IN cord-028721-x6f26ahr 2194 8 the the DT cord-028721-x6f26ahr 2194 9 plasma plasma NN cord-028721-x6f26ahr 2194 10 indicates indicate VBZ cord-028721-x6f26ahr 2194 11 the the DT cord-028721-x6f26ahr 2194 12 degree degree NN cord-028721-x6f26ahr 2194 13 of of IN cord-028721-x6f26ahr 2194 14 Leydig Leydig NNP cord-028721-x6f26ahr 2194 15 cell cell NN cord-028721-x6f26ahr 2194 16 dysfunction dysfunction NN cord-028721-x6f26ahr 2194 17 . . . cord-028721-x6f26ahr 2195 1 Decreased decrease VBN cord-028721-x6f26ahr 2195 2 ratio ratio NN cord-028721-x6f26ahr 2195 3 with with IN cord-028721-x6f26ahr 2195 4 normal normal JJ cord-028721-x6f26ahr 2195 5 testosterone testosterone NN cord-028721-x6f26ahr 2195 6 level level NN cord-028721-x6f26ahr 2195 7 suggests suggest VBZ cord-028721-x6f26ahr 2195 8 compensated compensate VBN cord-028721-x6f26ahr 2195 9 dysfunction dysfunction NN cord-028721-x6f26ahr 2195 10 . . . cord-028721-x6f26ahr 2196 1 Patients patient NNS cord-028721-x6f26ahr 2196 2 with with IN cord-028721-x6f26ahr 2196 3 a a DT cord-028721-x6f26ahr 2196 4 ratio ratio NN cord-028721-x6f26ahr 2196 5 of of IN cord-028721-x6f26ahr 2196 6 less less JJR cord-028721-x6f26ahr 2196 7 than than IN cord-028721-x6f26ahr 2196 8 1 1 CD cord-028721-x6f26ahr 2196 9 : : SYM cord-028721-x6f26ahr 2196 10 5 5 CD cord-028721-x6f26ahr 2196 11 and and CC cord-028721-x6f26ahr 2196 12 normal normal JJ cord-028721-x6f26ahr 2196 13 other other JJ cord-028721-x6f26ahr 2196 14 parameters parameter NNS cord-028721-x6f26ahr 2196 15 may may MD cord-028721-x6f26ahr 2196 16 have have VB cord-028721-x6f26ahr 2196 17 complete complete JJ cord-028721-x6f26ahr 2196 18 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2196 19 . . . cord-028721-x6f26ahr 2197 1 951 951 CD cord-028721-x6f26ahr 2197 2 Androgen androgen NN cord-028721-x6f26ahr 2197 3 insensitivity insensitivity NN cord-028721-x6f26ahr 2197 4 . . . cord-028721-x6f26ahr 2198 1 Some some DT cord-028721-x6f26ahr 2198 2 patients patient NNS cord-028721-x6f26ahr 2198 3 with with IN cord-028721-x6f26ahr 2198 4 severe severe JJ cord-028721-x6f26ahr 2198 5 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2198 6 or or CC cord-028721-x6f26ahr 2198 7 azoospermia azoospermia NN cord-028721-x6f26ahr 2198 8 have have VBP cord-028721-x6f26ahr 2198 9 a a DT cord-028721-x6f26ahr 2198 10 defect defect NN cord-028721-x6f26ahr 2198 11 in in IN cord-028721-x6f26ahr 2198 12 androgen androgen NN cord-028721-x6f26ahr 2198 13 receptor receptor NN cord-028721-x6f26ahr 2198 14 responsiveness responsiveness NN cord-028721-x6f26ahr 2198 15 , , , cord-028721-x6f26ahr 2198 16 similar similar JJ cord-028721-x6f26ahr 2198 17 to to IN cord-028721-x6f26ahr 2198 18 that that DT cord-028721-x6f26ahr 2198 19 in in IN cord-028721-x6f26ahr 2198 20 Reifenstein Reifenstein NNP cord-028721-x6f26ahr 2198 21 's 's POS cord-028721-x6f26ahr 2198 22 syndrome syndrome NN cord-028721-x6f26ahr 2198 23 . . . cord-028721-x6f26ahr 2199 1 [ [ -LRB- cord-028721-x6f26ahr 2199 2 952 952 CD cord-028721-x6f26ahr 2199 3 ] ] -RRB- cord-028721-x6f26ahr 2199 4 [ [ -LRB- cord-028721-x6f26ahr 2199 5 953 953 CD cord-028721-x6f26ahr 2199 6 ] ] -RRB- cord-028721-x6f26ahr 2199 7 [ [ -LRB- cord-028721-x6f26ahr 2199 8 954 954 CD cord-028721-x6f26ahr 2199 9 ] ] -RRB- cord-028721-x6f26ahr 2200 1 The the DT cord-028721-x6f26ahr 2200 2 abnormality abnormality NN cord-028721-x6f26ahr 2200 3 may may MD cord-028721-x6f26ahr 2200 4 arise arise VB cord-028721-x6f26ahr 2200 5 from from IN cord-028721-x6f26ahr 2200 6 a a DT cord-028721-x6f26ahr 2200 7 genetic genetic JJ cord-028721-x6f26ahr 2200 8 defect defect NN cord-028721-x6f26ahr 2200 9 in in IN cord-028721-x6f26ahr 2200 10 the the DT cord-028721-x6f26ahr 2200 11 eight eight CD cord-028721-x6f26ahr 2200 12 exons exon NNS cord-028721-x6f26ahr 2200 13 that that WDT cord-028721-x6f26ahr 2200 14 code code NN cord-028721-x6f26ahr 2200 15 for for IN cord-028721-x6f26ahr 2200 16 this this DT cord-028721-x6f26ahr 2200 17 receptor receptor NN cord-028721-x6f26ahr 2200 18 , , , cord-028721-x6f26ahr 2200 19 mapped map VBN cord-028721-x6f26ahr 2200 20 to to IN cord-028721-x6f26ahr 2200 21 Xq11 Xq11 NNP cord-028721-x6f26ahr 2200 22 - - HYPH cord-028721-x6f26ahr 2200 23 12 12 CD cord-028721-x6f26ahr 2200 24 , , , cord-028721-x6f26ahr 2200 25 955 955 CD cord-028721-x6f26ahr 2200 26 or or CC cord-028721-x6f26ahr 2200 27 from from IN cord-028721-x6f26ahr 2200 28 post post JJ cord-028721-x6f26ahr 2200 29 - - JJ cord-028721-x6f26ahr 2200 30 translational translational JJ cord-028721-x6f26ahr 2200 31 errors error NNS cord-028721-x6f26ahr 2200 32 . . . cord-028721-x6f26ahr 2201 1 956 956 CD cord-028721-x6f26ahr 2201 2 , , , cord-028721-x6f26ahr 2201 3 957 957 CD cord-028721-x6f26ahr 2202 1 This this DT cord-028721-x6f26ahr 2202 2 defect defect NN cord-028721-x6f26ahr 2202 3 is be VBZ cord-028721-x6f26ahr 2202 4 also also RB cord-028721-x6f26ahr 2202 5 referred refer VBN cord-028721-x6f26ahr 2202 6 to to IN cord-028721-x6f26ahr 2202 7 as as RB cord-028721-x6f26ahr 2202 8 infertile infertile JJ cord-028721-x6f26ahr 2202 9 male male JJ cord-028721-x6f26ahr 2202 10 syndrome syndrome NN cord-028721-x6f26ahr 2202 11 and and CC cord-028721-x6f26ahr 2202 12 mild mild JJ cord-028721-x6f26ahr 2202 13 androgen androgen NN cord-028721-x6f26ahr 2202 14 insensitivity insensitivity NN cord-028721-x6f26ahr 2202 15 , , , cord-028721-x6f26ahr 2202 16 and and CC cord-028721-x6f26ahr 2202 17 the the DT cord-028721-x6f26ahr 2202 18 patients patient NNS cord-028721-x6f26ahr 2202 19 have have VBP cord-028721-x6f26ahr 2202 20 male male JJ cord-028721-x6f26ahr 2202 21 phenotype phenotype NN cord-028721-x6f26ahr 2202 22 with with IN cord-028721-x6f26ahr 2202 23 somatic somatic JJ cord-028721-x6f26ahr 2202 24 features feature NNS cord-028721-x6f26ahr 2202 25 of of IN cord-028721-x6f26ahr 2202 26 slight slight JJ cord-028721-x6f26ahr 2202 27 androgen androgen NN cord-028721-x6f26ahr 2202 28 defi defi NNP cord-028721-x6f26ahr 2202 29 cit cit NNP cord-028721-x6f26ahr 2202 30 . . . cord-028721-x6f26ahr 2203 1 958 958 CD cord-028721-x6f26ahr 2203 2 Histologically Histologically NNP cord-028721-x6f26ahr 2203 3 , , , cord-028721-x6f26ahr 2203 4 the the DT cord-028721-x6f26ahr 2203 5 testis testis NN cord-028721-x6f26ahr 2203 6 is be VBZ cord-028721-x6f26ahr 2203 7 similar similar JJ cord-028721-x6f26ahr 2203 8 to to IN cord-028721-x6f26ahr 2203 9 that that DT cord-028721-x6f26ahr 2203 10 observed observe VBN cord-028721-x6f26ahr 2203 11 with with IN cord-028721-x6f26ahr 2203 12 Leydig Leydig NNP cord-028721-x6f26ahr 2203 13 cell cell NN cord-028721-x6f26ahr 2203 14 dysfunction dysfunction NN cord-028721-x6f26ahr 2203 15 or or CC cord-028721-x6f26ahr 2203 16 mixed mixed JJ cord-028721-x6f26ahr 2203 17 atrophy atrophy NN cord-028721-x6f26ahr 2203 18 , , , cord-028721-x6f26ahr 2203 19 although although IN cord-028721-x6f26ahr 2203 20 the the DT cord-028721-x6f26ahr 2203 21 mechanism mechanism NN cord-028721-x6f26ahr 2203 22 causing cause VBG cord-028721-x6f26ahr 2203 23 the the DT cord-028721-x6f26ahr 2203 24 Leydig Leydig NNP cord-028721-x6f26ahr 2203 25 cell cell NN cord-028721-x6f26ahr 2203 26 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2203 27 is be VBZ cord-028721-x6f26ahr 2203 28 quite quite RB cord-028721-x6f26ahr 2203 29 different different JJ cord-028721-x6f26ahr 2203 30 ( ( -LRB- cord-028721-x6f26ahr 2203 31 Fig fig NN cord-028721-x6f26ahr 2203 32 . . . cord-028721-x6f26ahr 2203 33 _SP cord-028721-x6f26ahr 2204 1 12 12 CD cord-028721-x6f26ahr 2204 2 - - SYM cord-028721-x6f26ahr 2204 3 106 106 CD cord-028721-x6f26ahr 2204 4 ) ) -RRB- cord-028721-x6f26ahr 2204 5 . . . cord-028721-x6f26ahr 2205 1 Peripheral peripheral JJ cord-028721-x6f26ahr 2205 2 resistance resistance NN cord-028721-x6f26ahr 2205 3 to to IN cord-028721-x6f26ahr 2205 4 testosterone testosterone NN cord-028721-x6f26ahr 2205 5 action action NN cord-028721-x6f26ahr 2205 6 alters alter VBZ cord-028721-x6f26ahr 2205 7 regulation regulation NN cord-028721-x6f26ahr 2205 8 of of IN cord-028721-x6f26ahr 2205 9 the the DT cord-028721-x6f26ahr 2205 10 hypothalamohypophyseal hypothalamohypophyseal NN cord-028721-x6f26ahr 2205 11 - - HYPH cord-028721-x6f26ahr 2205 12 testicular testicular JJ cord-028721-x6f26ahr 2205 13 axis axis NN cord-028721-x6f26ahr 2205 14 , , , cord-028721-x6f26ahr 2205 15 and and CC cord-028721-x6f26ahr 2205 16 LH lh NN cord-028721-x6f26ahr 2205 17 and and CC cord-028721-x6f26ahr 2205 18 testosterone testosterone NN cord-028721-x6f26ahr 2205 19 levels level NNS cord-028721-x6f26ahr 2205 20 are be VBP cord-028721-x6f26ahr 2205 21 elevated elevated JJ cord-028721-x6f26ahr 2205 22 . . . cord-028721-x6f26ahr 2206 1 Androgen androgen NN cord-028721-x6f26ahr 2206 2 insensitivity insensitivity NN cord-028721-x6f26ahr 2206 3 causes cause VBZ cord-028721-x6f26ahr 2206 4 between between IN cord-028721-x6f26ahr 2206 5 10 10 CD cord-028721-x6f26ahr 2206 6 % % NN cord-028721-x6f26ahr 2206 7 959 959 CD cord-028721-x6f26ahr 2206 8 and and CC cord-028721-x6f26ahr 2206 9 40 40 CD cord-028721-x6f26ahr 2206 10 % % NN cord-028721-x6f26ahr 2206 11 960 960 CD cord-028721-x6f26ahr 2206 12 of of IN cord-028721-x6f26ahr 2206 13 all all DT cord-028721-x6f26ahr 2206 14 cases case NNS cord-028721-x6f26ahr 2206 15 of of IN cord-028721-x6f26ahr 2206 16 severe severe JJ cord-028721-x6f26ahr 2206 17 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2206 18 or or CC cord-028721-x6f26ahr 2206 19 azoospermia azoospermia NN cord-028721-x6f26ahr 2206 20 . . . cord-028721-x6f26ahr 2207 1 In in IN cord-028721-x6f26ahr 2207 2 such such JJ cord-028721-x6f26ahr 2207 3 cases case NNS cord-028721-x6f26ahr 2207 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2207 5 improves improve VBZ cord-028721-x6f26ahr 2207 6 with with IN cord-028721-x6f26ahr 2207 7 the the DT cord-028721-x6f26ahr 2207 8 administration administration NN cord-028721-x6f26ahr 2207 9 of of IN cord-028721-x6f26ahr 2207 10 tamoxifen tamoxifen NNP cord-028721-x6f26ahr 2207 11 citrate citrate NNP cord-028721-x6f26ahr 2207 12 , , , cord-028721-x6f26ahr 2207 13 960 960 CD cord-028721-x6f26ahr 2207 14 clomiphene clomiphene NNP cord-028721-x6f26ahr 2207 15 citrate citrate NN cord-028721-x6f26ahr 2207 16 , , , cord-028721-x6f26ahr 2207 17 or or CC cord-028721-x6f26ahr 2207 18 androgen androgen NN cord-028721-x6f26ahr 2207 19 therapy therapy NN cord-028721-x6f26ahr 2207 20 . . . cord-028721-x6f26ahr 2208 1 961 961 CD cord-028721-x6f26ahr 2208 2 , , , cord-028721-x6f26ahr 2208 3 962 962 CD cord-028721-x6f26ahr 2208 4 Calculation Calculation NNP cord-028721-x6f26ahr 2208 5 of of IN cord-028721-x6f26ahr 2208 6 the the DT cord-028721-x6f26ahr 2208 7 index index NN cord-028721-x6f26ahr 2208 8 of of IN cord-028721-x6f26ahr 2208 9 androgen androgen NN cord-028721-x6f26ahr 2208 10 insensitivity insensitivity NN cord-028721-x6f26ahr 2208 11 can can MD cord-028721-x6f26ahr 2208 12 be be VB cord-028721-x6f26ahr 2208 13 helpful helpful JJ cord-028721-x6f26ahr 2208 14 : : : cord-028721-x6f26ahr 2208 15 plasma plasma NN cord-028721-x6f26ahr 2208 16 LH LH NNP cord-028721-x6f26ahr 2208 17 ( ( -LRB- cord-028721-x6f26ahr 2208 18 mIU mIU NNP cord-028721-x6f26ahr 2208 19 / / SYM cord-028721-x6f26ahr 2208 20 mL ml NN cord-028721-x6f26ahr 2208 21 ) ) -RRB- cord-028721-x6f26ahr 2208 22 × × NN cord-028721-x6f26ahr 2208 23 plasma plasma NN cord-028721-x6f26ahr 2208 24 testosterone testosterone NN cord-028721-x6f26ahr 2208 25 levels level NNS cord-028721-x6f26ahr 2208 26 ( ( -LRB- cord-028721-x6f26ahr 2208 27 ng ng NN cord-028721-x6f26ahr 2208 28 / / SYM cord-028721-x6f26ahr 2208 29 mL mL NNP cord-028721-x6f26ahr 2208 30 ) ) -RRB- cord-028721-x6f26ahr 2208 31 . . . cord-028721-x6f26ahr 2209 1 In in IN cord-028721-x6f26ahr 2209 2 patients patient NNS cord-028721-x6f26ahr 2209 3 with with IN cord-028721-x6f26ahr 2209 4 androgen androgen NN cord-028721-x6f26ahr 2209 5 insensitivity insensitivity NN cord-028721-x6f26ahr 2209 6 , , , cord-028721-x6f26ahr 2209 7 the the DT cord-028721-x6f26ahr 2209 8 index index NN cord-028721-x6f26ahr 2209 9 is be VBZ cord-028721-x6f26ahr 2209 10 higher high JJR cord-028721-x6f26ahr 2209 11 than than IN cord-028721-x6f26ahr 2209 12 200 200 CD cord-028721-x6f26ahr 2209 13 ( ( -LRB- cord-028721-x6f26ahr 2209 14 normal normal JJ cord-028721-x6f26ahr 2209 15 is be VBZ cord-028721-x6f26ahr 2209 16 about about RB cord-028721-x6f26ahr 2209 17 102 102 CD cord-028721-x6f26ahr 2209 18 ) ) -RRB- cord-028721-x6f26ahr 2209 19 . . . cord-028721-x6f26ahr 2210 1 Physical physical JJ cord-028721-x6f26ahr 2210 2 and and CC cord-028721-x6f26ahr 2210 3 chemical chemical JJ cord-028721-x6f26ahr 2210 4 agents agent NNS cord-028721-x6f26ahr 2210 5 . . . cord-028721-x6f26ahr 2211 1 The the DT cord-028721-x6f26ahr 2211 2 number number NN cord-028721-x6f26ahr 2211 3 of of IN cord-028721-x6f26ahr 2211 4 chemicals chemical NNS cord-028721-x6f26ahr 2211 5 implicated implicate VBN cord-028721-x6f26ahr 2211 6 in in IN cord-028721-x6f26ahr 2211 7 infertility infertility NN cord-028721-x6f26ahr 2211 8 increases increase NNS cord-028721-x6f26ahr 2211 9 daily daily RB cord-028721-x6f26ahr 2211 10 . . . cord-028721-x6f26ahr 2212 1 A a DT cord-028721-x6f26ahr 2212 2 detailed detailed JJ cord-028721-x6f26ahr 2212 3 history history NN cord-028721-x6f26ahr 2212 4 is be VBZ cord-028721-x6f26ahr 2212 5 invaluable invaluable JJ cord-028721-x6f26ahr 2212 6 in in IN cord-028721-x6f26ahr 2212 7 evaluating evaluate VBG cord-028721-x6f26ahr 2212 8 these these DT cord-028721-x6f26ahr 2212 9 patients patient NNS cord-028721-x6f26ahr 2212 10 . . . cord-028721-x6f26ahr 2213 1 The the DT cord-028721-x6f26ahr 2213 2 same same JJ cord-028721-x6f26ahr 2213 3 is be VBZ cord-028721-x6f26ahr 2213 4 true true JJ cord-028721-x6f26ahr 2213 5 of of IN cord-028721-x6f26ahr 2213 6 physical physical JJ cord-028721-x6f26ahr 2213 7 agents agent NNS cord-028721-x6f26ahr 2213 8 such such JJ cord-028721-x6f26ahr 2213 9 as as IN cord-028721-x6f26ahr 2213 10 prolonged prolong VBN cord-028721-x6f26ahr 2213 11 exposure exposure NN cord-028721-x6f26ahr 2213 12 to to IN cord-028721-x6f26ahr 2213 13 heat heat NN cord-028721-x6f26ahr 2213 14 , , , cord-028721-x6f26ahr 2213 15 ionizing ionize VBG cord-028721-x6f26ahr 2213 16 radiation radiation NN cord-028721-x6f26ahr 2213 17 , , , cord-028721-x6f26ahr 2213 18 or or CC cord-028721-x6f26ahr 2213 19 microwave microwave NN cord-028721-x6f26ahr 2213 20 radiation radiation NN cord-028721-x6f26ahr 2213 21 . . . cord-028721-x6f26ahr 2214 1 963 963 CD cord-028721-x6f26ahr 2214 2 Etiology etiology NN cord-028721-x6f26ahr 2214 3 of of IN cord-028721-x6f26ahr 2214 4 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2214 5 associated associate VBN cord-028721-x6f26ahr 2214 6 with with IN cord-028721-x6f26ahr 2214 7 primary primary JJ cord-028721-x6f26ahr 2214 8 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2214 9 sloughing sloughing NN cord-028721-x6f26ahr 2214 10 . . . cord-028721-x6f26ahr 2215 1 Most Most JJS cord-028721-x6f26ahr 2215 2 testes testis NNS cord-028721-x6f26ahr 2215 3 with with IN cord-028721-x6f26ahr 2215 4 primary primary JJ cord-028721-x6f26ahr 2215 5 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2215 6 sloughing sloughing NN cord-028721-x6f26ahr 2215 7 have have VBP cord-028721-x6f26ahr 2215 8 varicocele varicocele NN cord-028721-x6f26ahr 2215 9 , , , cord-028721-x6f26ahr 2215 10 and and CC cord-028721-x6f26ahr 2215 11 this this DT cord-028721-x6f26ahr 2215 12 is be VBZ cord-028721-x6f26ahr 2215 13 commonly commonly RB cord-028721-x6f26ahr 2215 14 associated associate VBN cord-028721-x6f26ahr 2215 15 with with IN cord-028721-x6f26ahr 2215 16 infertility infertility NN cord-028721-x6f26ahr 2215 17 . . . cord-028721-x6f26ahr 2216 1 [ [ -LRB- cord-028721-x6f26ahr 2216 2 964 964 CD cord-028721-x6f26ahr 2216 3 ] ] -RRB- cord-028721-x6f26ahr 2216 4 [ [ -LRB- cord-028721-x6f26ahr 2216 5 965 965 CD cord-028721-x6f26ahr 2216 6 ] ] -RRB- cord-028721-x6f26ahr 2216 7 [ [ -LRB- cord-028721-x6f26ahr 2216 8 966 966 CD cord-028721-x6f26ahr 2216 9 ] ] -RRB- cord-028721-x6f26ahr 2217 1 [ [ -LRB- cord-028721-x6f26ahr 2217 2 967 967 CD cord-028721-x6f26ahr 2217 3 ] ] -RRB- cord-028721-x6f26ahr 2218 1 Varicocele Varicocele NNP cord-028721-x6f26ahr 2218 2 is be VBZ cord-028721-x6f26ahr 2218 3 found find VBN cord-028721-x6f26ahr 2218 4 in in IN cord-028721-x6f26ahr 2218 5 15 15 CD cord-028721-x6f26ahr 2218 6 % % NN cord-028721-x6f26ahr 2218 7 of of IN cord-028721-x6f26ahr 2218 8 the the DT cord-028721-x6f26ahr 2218 9 general general JJ cord-028721-x6f26ahr 2218 10 population population NN cord-028721-x6f26ahr 2218 11 , , , cord-028721-x6f26ahr 2218 12 and and CC cord-028721-x6f26ahr 2218 13 is be VBZ cord-028721-x6f26ahr 2218 14 present present JJ cord-028721-x6f26ahr 2218 15 in in IN cord-028721-x6f26ahr 2218 16 30 30 CD cord-028721-x6f26ahr 2218 17 - - SYM cord-028721-x6f26ahr 2218 18 40 40 CD cord-028721-x6f26ahr 2218 19 % % NN cord-028721-x6f26ahr 2218 20 of of IN cord-028721-x6f26ahr 2218 21 infertile infertile JJ cord-028721-x6f26ahr 2218 22 men man NNS cord-028721-x6f26ahr 2218 23 . . . cord-028721-x6f26ahr 2219 1 The the DT cord-028721-x6f26ahr 2219 2 mechanism mechanism NN cord-028721-x6f26ahr 2219 3 by by IN cord-028721-x6f26ahr 2219 4 which which WDT cord-028721-x6f26ahr 2219 5 varicocele varicocele NN cord-028721-x6f26ahr 2219 6 affects affect VBZ cord-028721-x6f26ahr 2219 7 fertility fertility NN cord-028721-x6f26ahr 2219 8 is be VBZ cord-028721-x6f26ahr 2219 9 unknown unknown JJ cord-028721-x6f26ahr 2219 10 . . . cord-028721-x6f26ahr 2220 1 Clinical clinical JJ cord-028721-x6f26ahr 2220 2 varicocele varicocele NN cord-028721-x6f26ahr 2220 3 may may MD cord-028721-x6f26ahr 2220 4 occur occur VB cord-028721-x6f26ahr 2220 5 without without IN cord-028721-x6f26ahr 2220 6 a a DT cord-028721-x6f26ahr 2220 7 testicular testicular JJ cord-028721-x6f26ahr 2220 8 lesion lesion NN cord-028721-x6f26ahr 2220 9 ( ( -LRB- cord-028721-x6f26ahr 2220 10 or or CC cord-028721-x6f26ahr 2220 11 only only RB cord-028721-x6f26ahr 2220 12 phlebectasis phlebectasis NNP cord-028721-x6f26ahr 2220 13 ) ) -RRB- cord-028721-x6f26ahr 2220 14 , , , cord-028721-x6f26ahr 2220 15 and and CC cord-028721-x6f26ahr 2220 16 subclinical subclinical JJ cord-028721-x6f26ahr 2220 17 varicocele varicocele NN cord-028721-x6f26ahr 2220 18 may may MD cord-028721-x6f26ahr 2220 19 be be VB cord-028721-x6f26ahr 2220 20 associated associate VBN cord-028721-x6f26ahr 2220 21 with with IN cord-028721-x6f26ahr 2220 22 severe severe JJ cord-028721-x6f26ahr 2220 23 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 2220 24 lesions lesion NNS cord-028721-x6f26ahr 2220 25 . . . cord-028721-x6f26ahr 2221 1 Increased increase VBN cord-028721-x6f26ahr 2221 2 testicular testicular NNP cord-028721-x6f26ahr 2221 3 temperature temperature NN cord-028721-x6f26ahr 2221 4 968 968 CD cord-028721-x6f26ahr 2221 5 , , , cord-028721-x6f26ahr 2221 6 969 969 CD cord-028721-x6f26ahr 2221 7 and and CC cord-028721-x6f26ahr 2221 8 compression compression NN cord-028721-x6f26ahr 2221 9 of of IN cord-028721-x6f26ahr 2221 10 intratesticular intratesticular JJ cord-028721-x6f26ahr 2221 11 sperm sperm NN cord-028721-x6f26ahr 2221 12 excretory excretory JJ cord-028721-x6f26ahr 2221 13 ducts duct NNS cord-028721-x6f26ahr 2221 14 by by IN cord-028721-x6f26ahr 2221 15 dilated dilated JJ cord-028721-x6f26ahr 2221 16 veins vein NNS cord-028721-x6f26ahr 2221 17 932 932 CD cord-028721-x6f26ahr 2221 18 are be VBP cord-028721-x6f26ahr 2221 19 the the DT cord-028721-x6f26ahr 2221 20 most most RBS cord-028721-x6f26ahr 2221 21 plausible plausible JJ cord-028721-x6f26ahr 2221 22 mechanisms mechanism NNS cord-028721-x6f26ahr 2221 23 . . . cord-028721-x6f26ahr 2222 1 In in IN cord-028721-x6f26ahr 2222 2 other other JJ cord-028721-x6f26ahr 2222 3 cases case NNS cord-028721-x6f26ahr 2222 4 , , , cord-028721-x6f26ahr 2222 5 primary primary JJ cord-028721-x6f26ahr 2222 6 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2222 7 sloughing slough VBG cord-028721-x6f26ahr 2222 8 results result NNS cord-028721-x6f26ahr 2222 9 from from IN cord-028721-x6f26ahr 2222 10 anomalies anomaly NNS cord-028721-x6f26ahr 2222 11 of of IN cord-028721-x6f26ahr 2222 12 primary primary JJ cord-028721-x6f26ahr 2222 13 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 2222 14 and and CC cord-028721-x6f26ahr 2222 15 spermatids spermatids NNP cord-028721-x6f26ahr 2222 16 , , , cord-028721-x6f26ahr 2222 17 suggesting suggest VBG cord-028721-x6f26ahr 2222 18 a a DT cord-028721-x6f26ahr 2222 19 meiotic meiotic JJ cord-028721-x6f26ahr 2222 20 anomaly anomaly NN cord-028721-x6f26ahr 2222 21 . . . cord-028721-x6f26ahr 2223 1 Finally finally RB cord-028721-x6f26ahr 2223 2 , , , cord-028721-x6f26ahr 2223 3 in in IN cord-028721-x6f26ahr 2223 4 some some DT cord-028721-x6f26ahr 2223 5 patients patient NNS cord-028721-x6f26ahr 2223 6 the the DT cord-028721-x6f26ahr 2223 7 cause cause NN cord-028721-x6f26ahr 2223 8 may may MD cord-028721-x6f26ahr 2223 9 be be VB cord-028721-x6f26ahr 2223 10 the the DT cord-028721-x6f26ahr 2223 11 presence presence NN cord-028721-x6f26ahr 2223 12 of of IN cord-028721-x6f26ahr 2223 13 involuting involute VBG cord-028721-x6f26ahr 2223 14 Sertoli sertoli JJ cord-028721-x6f26ahr 2223 15 cells cell NNS cord-028721-x6f26ahr 2223 16 . . . cord-028721-x6f26ahr 2224 1 Spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2224 2 maturation maturation NN cord-028721-x6f26ahr 2224 3 arrest arrest NN cord-028721-x6f26ahr 2224 4 Spermatogonial Spermatogonial NNP cord-028721-x6f26ahr 2224 5 maturation maturation NN cord-028721-x6f26ahr 2224 6 arrest arrest NN cord-028721-x6f26ahr 2224 7 is be VBZ cord-028721-x6f26ahr 2224 8 a a DT cord-028721-x6f26ahr 2224 9 disorder disorder NN cord-028721-x6f26ahr 2224 10 defi defi NNP cord-028721-x6f26ahr 2224 11 ned ned NNP cord-028721-x6f26ahr 2224 12 by by IN cord-028721-x6f26ahr 2224 13 the the DT cord-028721-x6f26ahr 2224 14 presence presence NN cord-028721-x6f26ahr 2224 15 of of IN cord-028721-x6f26ahr 2224 16 fewer few JJR cord-028721-x6f26ahr 2224 17 than than IN cord-028721-x6f26ahr 2224 18 17 17 CD cord-028721-x6f26ahr 2224 19 spermatogonia spermatogonium NNS cord-028721-x6f26ahr 2224 20 per per IN cord-028721-x6f26ahr 2224 21 cross cross JJ cord-028721-x6f26ahr 2224 22 - - JJ cord-028721-x6f26ahr 2224 23 sectioned section VBN cord-028721-x6f26ahr 2224 24 tubule tubule NN cord-028721-x6f26ahr 2224 25 and and CC cord-028721-x6f26ahr 2224 26 even even RB cord-028721-x6f26ahr 2224 27 fewer few JJR cord-028721-x6f26ahr 2224 28 primary primary JJ cord-028721-x6f26ahr 2224 29 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2224 30 . . . cord-028721-x6f26ahr 2225 1 Spermatids spermatid NNS cord-028721-x6f26ahr 2225 2 are be VBP cord-028721-x6f26ahr 2225 3 usually usually RB cord-028721-x6f26ahr 2225 4 absent absent JJ cord-028721-x6f26ahr 2225 5 . . . cord-028721-x6f26ahr 2226 1 There there EX cord-028721-x6f26ahr 2226 2 have have VBP cord-028721-x6f26ahr 2226 3 been be VBN cord-028721-x6f26ahr 2226 4 attempts attempt NNS cord-028721-x6f26ahr 2226 5 to to TO cord-028721-x6f26ahr 2226 6 correlate correlate VB cord-028721-x6f26ahr 2226 7 the the DT cord-028721-x6f26ahr 2226 8 etiology etiology NN cord-028721-x6f26ahr 2226 9 of of IN cord-028721-x6f26ahr 2226 10 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2226 11 maturation maturation NN cord-028721-x6f26ahr 2226 12 arrest arrest NN cord-028721-x6f26ahr 2226 13 with with IN cord-028721-x6f26ahr 2226 14 the the DT cord-028721-x6f26ahr 2226 15 Sertoli sertoli JJ cord-028721-x6f26ahr 2226 16 cell cell NN cord-028721-x6f26ahr 2226 17 type type NN cord-028721-x6f26ahr 2226 18 present present JJ cord-028721-x6f26ahr 2226 19 . . . cord-028721-x6f26ahr 2227 1 970 970 CD cord-028721-x6f26ahr 2228 1 Immature immature JJ cord-028721-x6f26ahr 2228 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 2228 3 cells cell NNS cord-028721-x6f26ahr 2228 4 are be VBP cord-028721-x6f26ahr 2228 5 characteristic characteristic JJ cord-028721-x6f26ahr 2228 6 of of IN cord-028721-x6f26ahr 2228 7 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2228 8 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2228 9 and and CC cord-028721-x6f26ahr 2228 10 some some DT cord-028721-x6f26ahr 2228 11 syndromes syndrome NNS cord-028721-x6f26ahr 2228 12 with with IN cord-028721-x6f26ahr 2228 13 androgen androgen NN cord-028721-x6f26ahr 2228 14 insensitivity insensitivity NN cord-028721-x6f26ahr 2228 15 ( ( -LRB- cord-028721-x6f26ahr 2228 16 Fig Fig NNP cord-028721-x6f26ahr 2228 17 . . . cord-028721-x6f26ahr 2228 18 12 12 CD cord-028721-x6f26ahr 2228 19 - - SYM cord-028721-x6f26ahr 2228 20 107 107 CD cord-028721-x6f26ahr 2228 21 ) ) -RRB- cord-028721-x6f26ahr 2228 22 . . . cord-028721-x6f26ahr 2229 1 Mature mature JJ cord-028721-x6f26ahr 2229 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 2229 3 cells cell NNS cord-028721-x6f26ahr 2229 4 , , , cord-028721-x6f26ahr 2229 5 if if IN cord-028721-x6f26ahr 2229 6 their -PRON- PRP$ cord-028721-x6f26ahr 2229 7 presence presence NN cord-028721-x6f26ahr 2229 8 is be VBZ cord-028721-x6f26ahr 2229 9 unilateral unilateral JJ cord-028721-x6f26ahr 2229 10 , , , cord-028721-x6f26ahr 2229 11 are be VBP cord-028721-x6f26ahr 2229 12 observed observe VBN cord-028721-x6f26ahr 2229 13 in in IN cord-028721-x6f26ahr 2229 14 varicocele varicocele NN cord-028721-x6f26ahr 2229 15 , , , cord-028721-x6f26ahr 2229 16 epididymitis epididymitis NN cord-028721-x6f26ahr 2229 17 , , , cord-028721-x6f26ahr 2229 18 and and CC cord-028721-x6f26ahr 2229 19 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2229 20 testicular testicular JJ cord-028721-x6f26ahr 2229 21 traumatism traumatism NN cord-028721-x6f26ahr 2229 22 , , , cord-028721-x6f26ahr 2229 23 but but CC cord-028721-x6f26ahr 2229 24 if if IN cord-028721-x6f26ahr 2229 25 they -PRON- PRP cord-028721-x6f26ahr 2229 26 appear appear VBP cord-028721-x6f26ahr 2229 27 in in IN cord-028721-x6f26ahr 2229 28 both both DT cord-028721-x6f26ahr 2229 29 testes testis NNS cord-028721-x6f26ahr 2229 30 the the DT cord-028721-x6f26ahr 2229 31 etiology etiology NN cord-028721-x6f26ahr 2229 32 is be VBZ cord-028721-x6f26ahr 2229 33 unknown unknown JJ cord-028721-x6f26ahr 2229 34 . . . cord-028721-x6f26ahr 2230 1 Involuting Involuting NNP cord-028721-x6f26ahr 2230 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 2230 3 cells cell NNS cord-028721-x6f26ahr 2230 4 are be VBP cord-028721-x6f26ahr 2230 5 usually usually RB cord-028721-x6f26ahr 2230 6 present present JJ cord-028721-x6f26ahr 2230 7 bilaterally bilaterally RB cord-028721-x6f26ahr 2230 8 ; ; : cord-028721-x6f26ahr 2230 9 some some DT cord-028721-x6f26ahr 2230 10 cases case NNS cord-028721-x6f26ahr 2230 11 are be VBP cord-028721-x6f26ahr 2230 12 idiopathic idiopathic JJ cord-028721-x6f26ahr 2230 13 , , , cord-028721-x6f26ahr 2230 14 whereas whereas IN cord-028721-x6f26ahr 2230 15 others other NNS cord-028721-x6f26ahr 2230 16 are be VBP cord-028721-x6f26ahr 2230 17 associated associate VBN cord-028721-x6f26ahr 2230 18 with with IN cord-028721-x6f26ahr 2230 19 a a DT cord-028721-x6f26ahr 2230 20 history history NN cord-028721-x6f26ahr 2230 21 of of IN cord-028721-x6f26ahr 2230 22 alcoholism alcoholism NN cord-028721-x6f26ahr 2230 23 or or CC cord-028721-x6f26ahr 2230 24 chemotherapy chemotherapy NN cord-028721-x6f26ahr 2230 25 . . . cord-028721-x6f26ahr 2231 1 Dedifferentiated dedifferentiated JJ cord-028721-x6f26ahr 2231 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 2231 3 cells cell NNS cord-028721-x6f26ahr 2231 4 are be VBP cord-028721-x6f26ahr 2231 5 found find VBN cord-028721-x6f26ahr 2231 6 in in IN cord-028721-x6f26ahr 2231 7 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2231 8 maturation maturation NN cord-028721-x6f26ahr 2231 9 arrest arrest NN cord-028721-x6f26ahr 2231 10 caused cause VBN cord-028721-x6f26ahr 2231 11 by by IN cord-028721-x6f26ahr 2231 12 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 2231 13 inhibition inhibition NN cord-028721-x6f26ahr 2231 14 in in IN cord-028721-x6f26ahr 2231 15 treatment treatment NN cord-028721-x6f26ahr 2231 16 with with IN cord-028721-x6f26ahr 2231 17 estrogen estrogen NN cord-028721-x6f26ahr 2231 18 , , , cord-028721-x6f26ahr 2231 19 -releasing -release VBG cord-028721-x6f26ahr 2231 20 hormone hormone NN cord-028721-x6f26ahr 2231 21 agonist agonist NN cord-028721-x6f26ahr 2231 22 , , , cord-028721-x6f26ahr 2231 23 or or CC cord-028721-x6f26ahr 2231 24 anti anti JJ cord-028721-x6f26ahr 2231 25 - - NN cord-028721-x6f26ahr 2231 26 androgen androgen JJ cord-028721-x6f26ahr 2231 27 . . . cord-028721-x6f26ahr 2231 28 971 971 CD cord-028721-x6f26ahr 2231 29 _SP cord-028721-x6f26ahr 2232 1 Mixed mixed JJ cord-028721-x6f26ahr 2232 2 atrophy atrophy NN cord-028721-x6f26ahr 2232 3 is be VBZ cord-028721-x6f26ahr 2232 4 a a DT cord-028721-x6f26ahr 2232 5 descriptive descriptive JJ cord-028721-x6f26ahr 2232 6 term term NN cord-028721-x6f26ahr 2232 7 for for IN cord-028721-x6f26ahr 2232 8 the the DT cord-028721-x6f26ahr 2232 9 coexistence coexistence NN cord-028721-x6f26ahr 2232 10 , , , cord-028721-x6f26ahr 2232 11 in in IN cord-028721-x6f26ahr 2232 12 the the DT cord-028721-x6f26ahr 2232 13 same same JJ cord-028721-x6f26ahr 2232 14 testis testis NN cord-028721-x6f26ahr 2232 15 , , , cord-028721-x6f26ahr 2232 16 of of IN cord-028721-x6f26ahr 2232 17 tubules tubule NNS cord-028721-x6f26ahr 2232 18 containing contain VBG cord-028721-x6f26ahr 2232 19 only only RB cord-028721-x6f26ahr 2232 20 Sertoli sertoli JJ cord-028721-x6f26ahr 2232 21 cells cell NNS cord-028721-x6f26ahr 2232 22 and and CC cord-028721-x6f26ahr 2232 23 tubules tubule NNS cord-028721-x6f26ahr 2232 24 with with IN cord-028721-x6f26ahr 2232 25 complete complete JJ cord-028721-x6f26ahr 2232 26 or or CC cord-028721-x6f26ahr 2232 27 incomplete incomplete JJ cord-028721-x6f26ahr 2232 28 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2232 29 . . . cord-028721-x6f26ahr 2233 1 972 972 CD cord-028721-x6f26ahr 2234 1 This this DT cord-028721-x6f26ahr 2234 2 disorder disorder NN cord-028721-x6f26ahr 2234 3 includes include VBZ cord-028721-x6f26ahr 2234 4 patchy patchy JJ cord-028721-x6f26ahr 2234 5 failure failure NN cord-028721-x6f26ahr 2234 6 of of IN cord-028721-x6f26ahr 2234 7 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2234 8 and and CC cord-028721-x6f26ahr 2234 9 partial partial JJ cord-028721-x6f26ahr 2234 10 del del NNP cord-028721-x6f26ahr 2234 11 Castillo Castillo NNP cord-028721-x6f26ahr 2234 12 's 's POS cord-028721-x6f26ahr 2234 13 syndrome syndrome NN cord-028721-x6f26ahr 2234 14 . . . cord-028721-x6f26ahr 2235 1 The the DT cord-028721-x6f26ahr 2235 2 extent extent NN cord-028721-x6f26ahr 2235 3 of of IN cord-028721-x6f26ahr 2235 4 Sertoli sertoli JJ cord-028721-x6f26ahr 2235 5 cell cell NN cord-028721-x6f26ahr 2235 6 - - HYPH cord-028721-x6f26ahr 2235 7 only only RB cord-028721-x6f26ahr 2235 8 tubules tubule NNS cord-028721-x6f26ahr 2235 9 varies vary VBZ cord-028721-x6f26ahr 2235 10 widely widely RB cord-028721-x6f26ahr 2235 11 . . . cord-028721-x6f26ahr 2236 1 Tubules tubule NNS cord-028721-x6f26ahr 2236 2 with with IN cord-028721-x6f26ahr 2236 3 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2236 4 may may MD cord-028721-x6f26ahr 2236 5 be be VB cord-028721-x6f26ahr 2236 6 normal normal JJ cord-028721-x6f26ahr 2236 7 or or CC cord-028721-x6f26ahr 2236 8 partially partially RB cord-028721-x6f26ahr 2236 9 atrophic atrophic JJ cord-028721-x6f26ahr 2236 10 . . . cord-028721-x6f26ahr 2237 1 Tubular tubular JJ cord-028721-x6f26ahr 2237 2 hyalinization hyalinization NN cord-028721-x6f26ahr 2237 3 is be VBZ cord-028721-x6f26ahr 2237 4 occasionally occasionally RB cord-028721-x6f26ahr 2237 5 seen see VBN cord-028721-x6f26ahr 2237 6 ( ( -LRB- cord-028721-x6f26ahr 2237 7 Fig fig NN cord-028721-x6f26ahr 2237 8 . . . cord-028721-x6f26ahr 2237 9 _SP cord-028721-x6f26ahr 2237 10 12 12 CD cord-028721-x6f26ahr 2237 11 - - SYM cord-028721-x6f26ahr 2237 12 108 108 CD cord-028721-x6f26ahr 2237 13 ) ) -RRB- cord-028721-x6f26ahr 2237 14 . . . cord-028721-x6f26ahr 2238 1 Mixed mixed JJ cord-028721-x6f26ahr 2238 2 atrophy atrophy NN cord-028721-x6f26ahr 2238 3 is be VBZ cord-028721-x6f26ahr 2238 4 more more RBR cord-028721-x6f26ahr 2238 5 common common JJ cord-028721-x6f26ahr 2238 6 than than IN cord-028721-x6f26ahr 2238 7 suggested suggest VBN cord-028721-x6f26ahr 2238 8 by by IN cord-028721-x6f26ahr 2238 9 the the DT cord-028721-x6f26ahr 2238 10 literature literature NN cord-028721-x6f26ahr 2238 11 , , , cord-028721-x6f26ahr 2238 12 and and CC cord-028721-x6f26ahr 2238 13 many many JJ cord-028721-x6f26ahr 2238 14 cases case NNS cord-028721-x6f26ahr 2238 15 are be VBP cord-028721-x6f26ahr 2238 16 included include VBN cord-028721-x6f26ahr 2238 17 under under IN cord-028721-x6f26ahr 2238 18 other other JJ cord-028721-x6f26ahr 2238 19 diagnoses diagnosis NNS cord-028721-x6f26ahr 2238 20 , , , cord-028721-x6f26ahr 2238 21 such such JJ cord-028721-x6f26ahr 2238 22 as as IN cord-028721-x6f26ahr 2238 23 ' ' `` cord-028721-x6f26ahr 2238 24 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2238 25 with with IN cord-028721-x6f26ahr 2238 26 a a DT cord-028721-x6f26ahr 2238 27 severe severe JJ cord-028721-x6f26ahr 2238 28 germ germ NN cord-028721-x6f26ahr 2238 29 cell cell NN cord-028721-x6f26ahr 2238 30 depletion depletion NN cord-028721-x6f26ahr 2238 31 in in IN cord-028721-x6f26ahr 2238 32 such such PDT cord-028721-x6f26ahr 2238 33 a a DT cord-028721-x6f26ahr 2238 34 way way NN cord-028721-x6f26ahr 2238 35 that that WDT cord-028721-x6f26ahr 2238 36 some some DT cord-028721-x6f26ahr 2238 37 Sertoli sertoli JJ cord-028721-x6f26ahr 2238 38 cell cell NN cord-028721-x6f26ahr 2238 39 - - HYPH cord-028721-x6f26ahr 2238 40 only only JJ cord-028721-x6f26ahr 2238 41 tubules tubule NNS cord-028721-x6f26ahr 2238 42 are be VBP cord-028721-x6f26ahr 2238 43 seen see VBN cord-028721-x6f26ahr 2238 44 , , , cord-028721-x6f26ahr 2238 45 ' ' '' cord-028721-x6f26ahr 2238 46 859 859 CD cord-028721-x6f26ahr 2238 47 and and CC cord-028721-x6f26ahr 2239 1 ' ' `` cord-028721-x6f26ahr 2239 2 Sertoli sertoli JJ cord-028721-x6f26ahr 2239 3 cell cell NN cord-028721-x6f26ahr 2239 4 - - HYPH cord-028721-x6f26ahr 2239 5 only only RB cord-028721-x6f26ahr 2239 6 syndromes syndrome NNS cord-028721-x6f26ahr 2239 7 with with IN cord-028721-x6f26ahr 2239 8 focal focal JJ cord-028721-x6f26ahr 2239 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2239 10 . . . cord-028721-x6f26ahr 2239 11 ' ' '' cord-028721-x6f26ahr 2240 1 973 973 CD cord-028721-x6f26ahr 2240 2 Serial serial JJ cord-028721-x6f26ahr 2240 3 sections section NNS cord-028721-x6f26ahr 2240 4 from from IN cord-028721-x6f26ahr 2240 5 testes testis NNS cord-028721-x6f26ahr 2240 6 with with IN cord-028721-x6f26ahr 2240 7 mixed mixed JJ cord-028721-x6f26ahr 2240 8 atrophy atrophy NN cord-028721-x6f26ahr 2240 9 reveal reveal VBP cord-028721-x6f26ahr 2240 10 that that IN cord-028721-x6f26ahr 2240 11 the the DT cord-028721-x6f26ahr 2240 12 two two CD cord-028721-x6f26ahr 2240 13 different different JJ cord-028721-x6f26ahr 2240 14 types type NNS cord-028721-x6f26ahr 2240 15 of of IN cord-028721-x6f26ahr 2240 16 tubule tubule NN cord-028721-x6f26ahr 2240 17 are be VBP cord-028721-x6f26ahr 2240 18 grouped group VBN cord-028721-x6f26ahr 2240 19 according accord VBG cord-028721-x6f26ahr 2240 20 to to IN cord-028721-x6f26ahr 2240 21 their -PRON- PRP$ cord-028721-x6f26ahr 2240 22 histologic histologic JJ cord-028721-x6f26ahr 2240 23 pattern pattern NN cord-028721-x6f26ahr 2240 24 , , , cord-028721-x6f26ahr 2240 25 suggesting suggest VBG cord-028721-x6f26ahr 2240 26 that that IN cord-028721-x6f26ahr 2240 27 the the DT cord-028721-x6f26ahr 2240 28 distribution distribution NN cord-028721-x6f26ahr 2240 29 is be VBZ cord-028721-x6f26ahr 2240 30 by by IN cord-028721-x6f26ahr 2240 31 testicular testicular JJ cord-028721-x6f26ahr 2240 32 lobules lobule NNS cord-028721-x6f26ahr 2240 33 . . . cord-028721-x6f26ahr 2241 1 In in IN cord-028721-x6f26ahr 2241 2 cases case NNS cord-028721-x6f26ahr 2241 3 of of IN cord-028721-x6f26ahr 2241 4 mixed mixed JJ cord-028721-x6f26ahr 2241 5 atrophy atrophy NN cord-028721-x6f26ahr 2241 6 , , , cord-028721-x6f26ahr 2241 7 the the DT cord-028721-x6f26ahr 2241 8 percentage percentage NN cord-028721-x6f26ahr 2241 9 of of IN cord-028721-x6f26ahr 2241 10 tubules tubule NNS cord-028721-x6f26ahr 2241 11 with with IN cord-028721-x6f26ahr 2241 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2241 13 , , , cord-028721-x6f26ahr 2241 14 the the DT cord-028721-x6f26ahr 2241 15 degree degree NN cord-028721-x6f26ahr 2241 16 of of IN cord-028721-x6f26ahr 2241 17 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 2241 18 development development NN cord-028721-x6f26ahr 2241 19 in in IN cord-028721-x6f26ahr 2241 20 the the DT cord-028721-x6f26ahr 2241 21 tubules tubule NNS cord-028721-x6f26ahr 2241 22 , , , cord-028721-x6f26ahr 2241 23 and and CC cord-028721-x6f26ahr 2241 24 the the DT cord-028721-x6f26ahr 2241 25 type type NN cord-028721-x6f26ahr 2241 26 of of IN cord-028721-x6f26ahr 2241 27 Sertoli sertoli JJ cord-028721-x6f26ahr 2241 28 cell cell NN cord-028721-x6f26ahr 2241 29 present present NN cord-028721-x6f26ahr 2241 30 should should MD cord-028721-x6f26ahr 2241 31 be be VB cord-028721-x6f26ahr 2241 32 reported report VBN cord-028721-x6f26ahr 2241 33 . . . cord-028721-x6f26ahr 2242 1 Correlation correlation NN cord-028721-x6f26ahr 2242 2 of of IN cord-028721-x6f26ahr 2242 3 the the DT cord-028721-x6f26ahr 2242 4 fi fi NN cord-028721-x6f26ahr 2242 5 rst rst NNP cord-028721-x6f26ahr 2242 6 two two CD cord-028721-x6f26ahr 2242 7 with with IN cord-028721-x6f26ahr 2242 8 the the DT cord-028721-x6f26ahr 2242 9 spermiogram spermiogram NNP cord-028721-x6f26ahr 2242 10 gives give VBZ cord-028721-x6f26ahr 2242 11 an an DT cord-028721-x6f26ahr 2242 12 indication indication NN cord-028721-x6f26ahr 2242 13 of of IN cord-028721-x6f26ahr 2242 14 prognosis prognosis NN cord-028721-x6f26ahr 2242 15 , , , cord-028721-x6f26ahr 2242 16 and and CC cord-028721-x6f26ahr 2242 17 the the DT cord-028721-x6f26ahr 2242 18 Sertoli sertoli JJ cord-028721-x6f26ahr 2242 19 cell cell NN cord-028721-x6f26ahr 2242 20 types type NNS cord-028721-x6f26ahr 2242 21 identifi identifi NNP cord-028721-x6f26ahr 2242 22 es es NNP cord-028721-x6f26ahr 2242 23 the the DT cord-028721-x6f26ahr 2242 24 nature nature NN cord-028721-x6f26ahr 2242 25 ( ( -LRB- cord-028721-x6f26ahr 2242 26 primary primary JJ cord-028721-x6f26ahr 2242 27 or or CC cord-028721-x6f26ahr 2242 28 secondary secondary JJ cord-028721-x6f26ahr 2242 29 ) ) -RRB- cord-028721-x6f26ahr 2242 30 of of IN cord-028721-x6f26ahr 2242 31 the the DT cord-028721-x6f26ahr 2242 32 lesion lesion NN cord-028721-x6f26ahr 2242 33 . . . cord-028721-x6f26ahr 2243 1 974 974 LS cord-028721-x6f26ahr 2243 2 Mixed mix VBN cord-028721-x6f26ahr 2243 3 atrophy atrophy NN cord-028721-x6f26ahr 2243 4 ( ( -LRB- cord-028721-x6f26ahr 2243 5 probably probably RB cord-028721-x6f26ahr 2243 6 primary primary JJ cord-028721-x6f26ahr 2243 7 ) ) -RRB- cord-028721-x6f26ahr 2243 8 is be VBZ cord-028721-x6f26ahr 2243 9 observed observe VBN cord-028721-x6f26ahr 2243 10 in in IN cord-028721-x6f26ahr 2243 11 idiopathic idiopathic JJ cord-028721-x6f26ahr 2243 12 infertility infertility NN cord-028721-x6f26ahr 2243 13 , , , cord-028721-x6f26ahr 2243 14 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2243 15 ( ( -LRB- cord-028721-x6f26ahr 2243 16 even even RB cord-028721-x6f26ahr 2243 17 if if IN cord-028721-x6f26ahr 2243 18 orchidopexy orchidopexy NN cord-028721-x6f26ahr 2243 19 was be VBD cord-028721-x6f26ahr 2243 20 done do VBN cord-028721-x6f26ahr 2243 21 at at IN cord-028721-x6f26ahr 2243 22 infancy infancy NN cord-028721-x6f26ahr 2243 23 , , , cord-028721-x6f26ahr 2243 24 in in IN cord-028721-x6f26ahr 2243 25 both both CC cord-028721-x6f26ahr 2243 26 the the DT cord-028721-x6f26ahr 2243 27 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 2243 28 and and CC cord-028721-x6f26ahr 2243 29 the the DT cord-028721-x6f26ahr 2243 30 contralateral contralateral JJ cord-028721-x6f26ahr 2243 31 descended descend VBN cord-028721-x6f26ahr 2243 32 testis testis NN cord-028721-x6f26ahr 2243 33 ) ) -RRB- cord-028721-x6f26ahr 2243 34 , , , cord-028721-x6f26ahr 2243 35 retractile retractile JJ cord-028721-x6f26ahr 2243 36 testes testis NNS cord-028721-x6f26ahr 2243 37 , , , cord-028721-x6f26ahr 2243 38 macroorchidism macroorchidism NN cord-028721-x6f26ahr 2243 39 , , , cord-028721-x6f26ahr 2243 40 intravaginal intravaginal JJ cord-028721-x6f26ahr 2243 41 torsion torsion NN cord-028721-x6f26ahr 2243 42 of of IN cord-028721-x6f26ahr 2243 43 the the DT cord-028721-x6f26ahr 2243 44 spermatic spermatic JJ cord-028721-x6f26ahr 2243 45 cord cord NN cord-028721-x6f26ahr 2243 46 ( ( -LRB- cord-028721-x6f26ahr 2243 47 in in IN cord-028721-x6f26ahr 2243 48 both both CC cord-028721-x6f26ahr 2243 49 twisted twisted JJ cord-028721-x6f26ahr 2243 50 and and CC cord-028721-x6f26ahr 2243 51 contralateral contralateral JJ cord-028721-x6f26ahr 2243 52 testis testis NN cord-028721-x6f26ahr 2243 53 ) ) -RRB- cord-028721-x6f26ahr 2243 54 , , , cord-028721-x6f26ahr 2243 55 and and CC cord-028721-x6f26ahr 2243 56 chromosomal chromosomal JJ cord-028721-x6f26ahr 2243 57 anomalies anomaly NNS cord-028721-x6f26ahr 2243 58 such such JJ cord-028721-x6f26ahr 2243 59 as as IN cord-028721-x6f26ahr 2243 60 Down Down NNP cord-028721-x6f26ahr 2243 61 's 's POS cord-028721-x6f26ahr 2243 62 syndrome syndrome NN cord-028721-x6f26ahr 2243 63 , , , cord-028721-x6f26ahr 2243 64 47 47 CD cord-028721-x6f26ahr 2243 65 / / SYM cord-028721-x6f26ahr 2243 66 XYY XYY NNP cord-028721-x6f26ahr 2243 67 karyotype karyotype NN cord-028721-x6f26ahr 2243 68 , , , cord-028721-x6f26ahr 2243 69 46 46 CD cord-028721-x6f26ahr 2243 70 / / SYM cord-028721-x6f26ahr 2243 71 XX xx NN cord-028721-x6f26ahr 2243 72 karyotype karyotype NN cord-028721-x6f26ahr 2243 73 , , , cord-028721-x6f26ahr 2243 74 Infertility Infertility NNP cord-028721-x6f26ahr 2243 75 giant giant NN cord-028721-x6f26ahr 2243 76 Y Y NNP cord-028721-x6f26ahr 2243 77 chromosome chromosome NN cord-028721-x6f26ahr 2243 78 , , , cord-028721-x6f26ahr 2243 79 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2243 80 's 's POS cord-028721-x6f26ahr 2243 81 syndrome syndrome NN cord-028721-x6f26ahr 2243 82 with with IN cord-028721-x6f26ahr 2243 83 chromosomal chromosomal JJ cord-028721-x6f26ahr 2243 84 mosaicism mosaicism NN cord-028721-x6f26ahr 2243 85 , , , cord-028721-x6f26ahr 2243 86 partial partial JJ cord-028721-x6f26ahr 2243 87 androgen androgen NN cord-028721-x6f26ahr 2243 88 insensitivity insensitivity NN cord-028721-x6f26ahr 2243 89 , , , cord-028721-x6f26ahr 2243 90 and and CC cord-028721-x6f26ahr 2243 91 some some DT cord-028721-x6f26ahr 2243 92 male male JJ cord-028721-x6f26ahr 2243 93 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 2243 94 . . . cord-028721-x6f26ahr 2244 1 Secondary secondary JJ cord-028721-x6f26ahr 2244 2 mixed mixed JJ cord-028721-x6f26ahr 2244 3 atrophy atrophy NN cord-028721-x6f26ahr 2244 4 may may MD cord-028721-x6f26ahr 2244 5 be be VB cord-028721-x6f26ahr 2244 6 seen see VBN cord-028721-x6f26ahr 2244 7 in in IN cord-028721-x6f26ahr 2244 8 patients patient NNS cord-028721-x6f26ahr 2244 9 undergoing undergo VBG cord-028721-x6f26ahr 2244 10 chemotherapy chemotherapy NN cord-028721-x6f26ahr 2244 11 , , , cord-028721-x6f26ahr 2244 12 corticoid corticoid NN cord-028721-x6f26ahr 2244 13 therapy therapy NN cord-028721-x6f26ahr 2244 14 , , , cord-028721-x6f26ahr 2244 15 975 975 CD cord-028721-x6f26ahr 2244 16 or or CC cord-028721-x6f26ahr 2244 17 in in IN cord-028721-x6f26ahr 2244 18 those those DT cord-028721-x6f26ahr 2244 19 with with IN cord-028721-x6f26ahr 2244 20 a a DT cord-028721-x6f26ahr 2244 21 history history NN cord-028721-x6f26ahr 2244 22 of of IN cord-028721-x6f26ahr 2244 23 viral viral JJ cord-028721-x6f26ahr 2244 24 orchitis orchitis NN cord-028721-x6f26ahr 2244 25 . . . cord-028721-x6f26ahr 2245 1 In in IN cord-028721-x6f26ahr 2245 2 addition addition NN cord-028721-x6f26ahr 2245 3 to to IN cord-028721-x6f26ahr 2245 4 anomalies anomaly NNS cord-028721-x6f26ahr 2245 5 in in IN cord-028721-x6f26ahr 2245 6 the the DT cord-028721-x6f26ahr 2245 7 seminiferous seminiferous JJ cord-028721-x6f26ahr 2245 8 tubules tubule NNS cord-028721-x6f26ahr 2245 9 , , , cord-028721-x6f26ahr 2245 10 examination examination NN cord-028721-x6f26ahr 2245 11 of of IN cord-028721-x6f26ahr 2245 12 the the DT cord-028721-x6f26ahr 2245 13 biopsy biopsy NN cord-028721-x6f26ahr 2245 14 should should MD cord-028721-x6f26ahr 2245 15 include include VB cord-028721-x6f26ahr 2245 16 a a DT cord-028721-x6f26ahr 2245 17 description description NN cord-028721-x6f26ahr 2245 18 of of IN cord-028721-x6f26ahr 2245 19 the the DT cord-028721-x6f26ahr 2245 20 morphology morphology NN cord-028721-x6f26ahr 2245 21 of of IN cord-028721-x6f26ahr 2245 22 the the DT cord-028721-x6f26ahr 2245 23 germ germ NN cord-028721-x6f26ahr 2245 24 cells cell NNS cord-028721-x6f26ahr 2245 25 . . . cord-028721-x6f26ahr 2246 1 Giant giant JJ cord-028721-x6f26ahr 2246 2 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2246 3 are be VBP cord-028721-x6f26ahr 2246 4 a a DT cord-028721-x6f26ahr 2246 5 normal normal JJ cord-028721-x6f26ahr 2246 6 component component NN cord-028721-x6f26ahr 2246 7 of of IN cord-028721-x6f26ahr 2246 8 the the DT cord-028721-x6f26ahr 2246 9 seminiferous seminiferous JJ cord-028721-x6f26ahr 2246 10 epithelium epithelium NN cord-028721-x6f26ahr 2246 11 . . . cord-028721-x6f26ahr 2247 1 These these DT cord-028721-x6f26ahr 2247 2 cells cell NNS cord-028721-x6f26ahr 2247 3 may may MD cord-028721-x6f26ahr 2247 4 be be VB cord-028721-x6f26ahr 2247 5 altered alter VBN cord-028721-x6f26ahr 2247 6 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2247 7 in in IN cord-028721-x6f26ahr 2247 8 the the DT cord-028721-x6f26ahr 2247 9 S S NNP cord-028721-x6f26ahr 2247 10 or or CC cord-028721-x6f26ahr 2247 11 G G NNP cord-028721-x6f26ahr 2247 12 2 2 CD cord-028721-x6f26ahr 2247 13 phases phase NNS cord-028721-x6f26ahr 2247 14 of of IN cord-028721-x6f26ahr 2247 15 the the DT cord-028721-x6f26ahr 2247 16 cell cell NN cord-028721-x6f26ahr 2247 17 cycle cycle NN cord-028721-x6f26ahr 2247 18 . . . cord-028721-x6f26ahr 2248 1 They -PRON- PRP cord-028721-x6f26ahr 2248 2 rest rest VBP cord-028721-x6f26ahr 2248 3 on on IN cord-028721-x6f26ahr 2248 4 the the DT cord-028721-x6f26ahr 2248 5 basal basal NN cord-028721-x6f26ahr 2248 6 lamina lamina NN cord-028721-x6f26ahr 2248 7 and and CC cord-028721-x6f26ahr 2248 8 have have VBP cord-028721-x6f26ahr 2248 9 pale pale JJ cord-028721-x6f26ahr 2248 10 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2248 11 and and CC cord-028721-x6f26ahr 2248 12 an an DT cord-028721-x6f26ahr 2248 13 ovoid ovoid JJ cord-028721-x6f26ahr 2248 14 nucleus nucleus NN cord-028721-x6f26ahr 2248 15 measuring measuring NN cord-028721-x6f26ahr 2249 1 at at RB cord-028721-x6f26ahr 2249 2 least least JJS cord-028721-x6f26ahr 2249 3 13 13 CD cord-028721-x6f26ahr 2249 4 µm µm NN cord-028721-x6f26ahr 2249 5 in in IN cord-028721-x6f26ahr 2249 6 diameter diameter NN cord-028721-x6f26ahr 2249 7 . . . cord-028721-x6f26ahr 2250 1 The the DT cord-028721-x6f26ahr 2250 2 frequency frequency NN cord-028721-x6f26ahr 2250 3 of of IN cord-028721-x6f26ahr 2250 4 these these DT cord-028721-x6f26ahr 2250 5 cells cell NNS cord-028721-x6f26ahr 2250 6 in in IN cord-028721-x6f26ahr 2250 7 normal normal JJ cord-028721-x6f26ahr 2250 8 and and CC cord-028721-x6f26ahr 2250 9 infertile infertile JJ cord-028721-x6f26ahr 2250 10 men man NNS cord-028721-x6f26ahr 2250 11 is be VBZ cord-028721-x6f26ahr 2250 12 about about RB cord-028721-x6f26ahr 2250 13 0.65 0.65 CD cord-028721-x6f26ahr 2250 14 cells cell NNS cord-028721-x6f26ahr 2250 15 per per IN cord-028721-x6f26ahr 2250 16 50 50 CD cord-028721-x6f26ahr 2250 17 cross cross NN cord-028721-x6f26ahr 2250 18 - - JJ cord-028721-x6f26ahr 2250 19 sectioned section VBN cord-028721-x6f26ahr 2250 20 tubules tubule NNS cord-028721-x6f26ahr 2250 21 , , , cord-028721-x6f26ahr 2250 22 although although IN cord-028721-x6f26ahr 2250 23 their -PRON- PRP$ cord-028721-x6f26ahr 2250 24 number number NN cord-028721-x6f26ahr 2250 25 is be VBZ cord-028721-x6f26ahr 2250 26 usually usually RB cord-028721-x6f26ahr 2250 27 higher high JJR cord-028721-x6f26ahr 2250 28 in in IN cord-028721-x6f26ahr 2250 29 mixed mixed JJ cord-028721-x6f26ahr 2250 30 atrophy atrophy NN cord-028721-x6f26ahr 2250 31 . . . cord-028721-x6f26ahr 2251 1 These these DT cord-028721-x6f26ahr 2251 2 cells cell NNS cord-028721-x6f26ahr 2251 3 should should MD cord-028721-x6f26ahr 2251 4 not not RB cord-028721-x6f26ahr 2251 5 be be VB cord-028721-x6f26ahr 2251 6 mistaken mistaken JJ cord-028721-x6f26ahr 2251 7 for for IN cord-028721-x6f26ahr 2251 8 intratubular intratubular JJ cord-028721-x6f26ahr 2251 9 germ germ NN cord-028721-x6f26ahr 2251 10 cell cell NN cord-028721-x6f26ahr 2251 11 neoplasia neoplasia NN cord-028721-x6f26ahr 2251 12 ; ; : cord-028721-x6f26ahr 2251 13 they -PRON- PRP cord-028721-x6f26ahr 2251 14 are be VBP cord-028721-x6f26ahr 2251 15 also also RB cord-028721-x6f26ahr 2251 16 present present JJ cord-028721-x6f26ahr 2251 17 in in IN cord-028721-x6f26ahr 2251 18 normal normal JJ cord-028721-x6f26ahr 2251 19 numbers number NNS cord-028721-x6f26ahr 2251 20 in in IN cord-028721-x6f26ahr 2251 21 tubules tubule NNS cord-028721-x6f26ahr 2251 22 at at IN cord-028721-x6f26ahr 2251 23 the the DT cord-028721-x6f26ahr 2251 24 periphery periphery NN cord-028721-x6f26ahr 2251 25 of of IN cord-028721-x6f26ahr 2251 26 germ germ NN cord-028721-x6f26ahr 2251 27 cell cell NN cord-028721-x6f26ahr 2251 28 tumor tumor NN cord-028721-x6f26ahr 2252 1 ( ( -LRB- cord-028721-x6f26ahr 2252 2 Fig Fig NNP cord-028721-x6f26ahr 2252 3 . . . cord-028721-x6f26ahr 2252 4 12 12 CD cord-028721-x6f26ahr 2252 5 - - SYM cord-028721-x6f26ahr 2252 6 109 109 CD cord-028721-x6f26ahr 2252 7 ) ) -RRB- cord-028721-x6f26ahr 2252 8 . . . cord-028721-x6f26ahr 2253 1 976 976 CD cord-028721-x6f26ahr 2253 2 _SP cord-028721-x6f26ahr 2254 1 Multinucleate Multinucleate NNP cord-028721-x6f26ahr 2254 2 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2254 3 are be VBP cord-028721-x6f26ahr 2254 4 a a DT cord-028721-x6f26ahr 2254 5 common common JJ cord-028721-x6f26ahr 2254 6 fi fi NN cord-028721-x6f26ahr 2254 7 nding nding NN cord-028721-x6f26ahr 2254 8 in in IN cord-028721-x6f26ahr 2254 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 2254 10 testes testis NNS cord-028721-x6f26ahr 2254 11 that that WDT cord-028721-x6f26ahr 2254 12 were be VBD cord-028721-x6f26ahr 2254 13 surgically surgically RB cord-028721-x6f26ahr 2254 14 corrected correct VBN cord-028721-x6f26ahr 2254 15 , , , cord-028721-x6f26ahr 2254 16 infertile infertile JJ cord-028721-x6f26ahr 2254 17 patients patient NNS cord-028721-x6f26ahr 2254 18 , , , cord-028721-x6f26ahr 2254 19 and and CC cord-028721-x6f26ahr 2254 20 old old JJ cord-028721-x6f26ahr 2254 21 men man NNS cord-028721-x6f26ahr 2254 22 . . . cord-028721-x6f26ahr 2255 1 Nuclei nuclei NN cord-028721-x6f26ahr 2255 2 of of IN cord-028721-x6f26ahr 2255 3 both both CC cord-028721-x6f26ahr 2255 4 Ad Ad NNP cord-028721-x6f26ahr 2255 5 and and CC cord-028721-x6f26ahr 2255 6 Ap Ap NNP cord-028721-x6f26ahr 2255 7 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2255 8 types type NNS cord-028721-x6f26ahr 2255 9 may may MD cord-028721-x6f26ahr 2255 10 be be VB cord-028721-x6f26ahr 2255 11 seen see VBN cord-028721-x6f26ahr 2255 12 within within IN cord-028721-x6f26ahr 2255 13 the the DT cord-028721-x6f26ahr 2255 14 same same JJ cord-028721-x6f26ahr 2255 15 cell cell NN cord-028721-x6f26ahr 2255 16 . . . cord-028721-x6f26ahr 2256 1 Normally normally RB cord-028721-x6f26ahr 2256 2 , , , cord-028721-x6f26ahr 2256 3 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2256 4 are be VBP cord-028721-x6f26ahr 2256 5 present present JJ cord-028721-x6f26ahr 2256 6 only only RB cord-028721-x6f26ahr 2256 7 in in IN cord-028721-x6f26ahr 2256 8 the the DT cord-028721-x6f26ahr 2256 9 transition transition NN cord-028721-x6f26ahr 2256 10 zone zone NN cord-028721-x6f26ahr 2256 11 between between IN cord-028721-x6f26ahr 2256 12 the the DT cord-028721-x6f26ahr 2256 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2256 14 tubule tubule NNP cord-028721-x6f26ahr 2256 15 basal basal NNP cord-028721-x6f26ahr 2256 16 layer layer NN cord-028721-x6f26ahr 2256 17 and and CC cord-028721-x6f26ahr 2256 18 the the DT cord-028721-x6f26ahr 2256 19 tubuli tubuli NNP cord-028721-x6f26ahr 2256 20 recti recti NNP cord-028721-x6f26ahr 2256 21 . . . cord-028721-x6f26ahr 2257 1 Dislocated dislocate VBN cord-028721-x6f26ahr 2257 2 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2257 3 have have VBP cord-028721-x6f26ahr 2257 4 been be VBN cord-028721-x6f26ahr 2257 5 found find VBN cord-028721-x6f26ahr 2257 6 throughout throughout IN cord-028721-x6f26ahr 2257 7 the the DT cord-028721-x6f26ahr 2257 8 testis testis NN cord-028721-x6f26ahr 2257 9 in in IN cord-028721-x6f26ahr 2257 10 old old JJ cord-028721-x6f26ahr 2257 11 age age NN cord-028721-x6f26ahr 2257 12 , , , cord-028721-x6f26ahr 2257 13 977 977 CD cord-028721-x6f26ahr 2257 14 in in IN cord-028721-x6f26ahr 2257 15 infertile infertile JJ cord-028721-x6f26ahr 2257 16 patients patient NNS cord-028721-x6f26ahr 2257 17 with with IN cord-028721-x6f26ahr 2257 18 a a DT cord-028721-x6f26ahr 2257 19 variety variety NN cord-028721-x6f26ahr 2257 20 of of IN cord-028721-x6f26ahr 2257 21 lesions lesion NNS cord-028721-x6f26ahr 2257 22 , , , cord-028721-x6f26ahr 2257 23 after after IN cord-028721-x6f26ahr 2257 24 long long JJ cord-028721-x6f26ahr 2257 25 - - HYPH cord-028721-x6f26ahr 2257 26 term term NN cord-028721-x6f26ahr 2257 27 estrogen estrogen NN cord-028721-x6f26ahr 2257 28 therapy therapy NN cord-028721-x6f26ahr 2257 29 , , , cord-028721-x6f26ahr 2257 30 978 978 CD cord-028721-x6f26ahr 2257 31 and and CC cord-028721-x6f26ahr 2257 32 in in IN cord-028721-x6f26ahr 2257 33 seminiferous seminiferous JJ cord-028721-x6f26ahr 2257 34 tubules tubule NNS cord-028721-x6f26ahr 2257 35 with with IN cord-028721-x6f26ahr 2257 36 intratubular intratubular JJ cord-028721-x6f26ahr 2257 37 germ germ NN cord-028721-x6f26ahr 2257 38 cell cell NN cord-028721-x6f26ahr 2257 39 neoplasia neoplasia NN cord-028721-x6f26ahr 2257 40 . . . cord-028721-x6f26ahr 2258 1 979 979 CD cord-028721-x6f26ahr 2258 2 _SP cord-028721-x6f26ahr 2259 1 Megalospermatocytes megalospermatocyte NNS cord-028721-x6f26ahr 2259 2 are be VBP cord-028721-x6f26ahr 2259 3 large large JJ cord-028721-x6f26ahr 2259 4 primary primary JJ cord-028721-x6f26ahr 2259 5 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2259 6 arrested arrest VBN cord-028721-x6f26ahr 2259 7 in in IN cord-028721-x6f26ahr 2259 8 the the DT cord-028721-x6f26ahr 2259 9 leptotene leptotene NN cord-028721-x6f26ahr 2259 10 stage stage NN cord-028721-x6f26ahr 2259 11 ( ( -LRB- cord-028721-x6f26ahr 2259 12 Fig Fig NNP cord-028721-x6f26ahr 2259 13 . . . cord-028721-x6f26ahr 2259 14 12 12 CD cord-028721-x6f26ahr 2259 15 - - SYM cord-028721-x6f26ahr 2259 16 110 110 CD cord-028721-x6f26ahr 2259 17 ) ) -RRB- cord-028721-x6f26ahr 2259 18 980 980 CD cord-028721-x6f26ahr 2259 19 that that WDT cord-028721-x6f26ahr 2259 20 exhibit exhibit VBP cord-028721-x6f26ahr 2259 21 asynapsis asynapsis NN cord-028721-x6f26ahr 2259 22 of of IN cord-028721-x6f26ahr 2259 23 chromosomes chromosome NNS cord-028721-x6f26ahr 2259 24 . . . cord-028721-x6f26ahr 2260 1 981 981 CD cord-028721-x6f26ahr 2261 1 Joined join VBN cord-028721-x6f26ahr 2261 2 by by IN cord-028721-x6f26ahr 2261 3 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2261 4 bridges bridge NNS cord-028721-x6f26ahr 2261 5 , , , cord-028721-x6f26ahr 2261 6 they -PRON- PRP cord-028721-x6f26ahr 2261 7 form form VBP cord-028721-x6f26ahr 2261 8 small small JJ cord-028721-x6f26ahr 2261 9 groups group NNS cord-028721-x6f26ahr 2261 10 . . . cord-028721-x6f26ahr 2262 1 These these DT cord-028721-x6f26ahr 2262 2 cells cell NNS cord-028721-x6f26ahr 2262 3 may may MD cord-028721-x6f26ahr 2262 4 be be VB cord-028721-x6f26ahr 2262 5 clones clone NNS cord-028721-x6f26ahr 2262 6 of of IN cord-028721-x6f26ahr 2262 7 synchronously synchronously RB cord-028721-x6f26ahr 2262 8 degenerating degenerate VBG cord-028721-x6f26ahr 2262 9 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2262 10 . . . cord-028721-x6f26ahr 2263 1 982 982 CD cord-028721-x6f26ahr 2264 1 They -PRON- PRP cord-028721-x6f26ahr 2264 2 are be VBP cord-028721-x6f26ahr 2264 3 frequently frequently RB cord-028721-x6f26ahr 2264 4 found find VBN cord-028721-x6f26ahr 2264 5 in in IN cord-028721-x6f26ahr 2264 6 elderly elderly JJ cord-028721-x6f26ahr 2264 7 men man NNS cord-028721-x6f26ahr 2264 8 and and CC cord-028721-x6f26ahr 2264 9 are be VBP cord-028721-x6f26ahr 2264 10 a a DT cord-028721-x6f26ahr 2264 11 non non JJ cord-028721-x6f26ahr 2264 12 - - JJ cord-028721-x6f26ahr 2264 13 specifi specifi JJ cord-028721-x6f26ahr 2264 14 c c NN cord-028721-x6f26ahr 2264 15 fi fi NN cord-028721-x6f26ahr 2264 16 nding nding NN cord-028721-x6f26ahr 2264 17 in in IN cord-028721-x6f26ahr 2264 18 infertile infertile JJ cord-028721-x6f26ahr 2264 19 patients patient NNS cord-028721-x6f26ahr 2264 20 . . . cord-028721-x6f26ahr 2265 1 The the DT cord-028721-x6f26ahr 2265 2 presence presence NN cord-028721-x6f26ahr 2265 3 of of IN cord-028721-x6f26ahr 2265 4 spermatids spermatid NNS cord-028721-x6f26ahr 2265 5 with with IN cord-028721-x6f26ahr 2265 6 multiple multiple JJ cord-028721-x6f26ahr 2265 7 nuclei nucleus NNS cord-028721-x6f26ahr 2265 8 ( ( -LRB- cord-028721-x6f26ahr 2265 9 from from IN cord-028721-x6f26ahr 2265 10 2 2 CD cord-028721-x6f26ahr 2265 11 to to IN cord-028721-x6f26ahr 2265 12 86 86 CD cord-028721-x6f26ahr 2265 13 ) ) -RRB- cord-028721-x6f26ahr 2265 14 is be VBZ cord-028721-x6f26ahr 2265 15 frequent frequent JJ cord-028721-x6f26ahr 2265 16 is be VBZ cord-028721-x6f26ahr 2265 17 old old JJ cord-028721-x6f26ahr 2265 18 age age NN cord-028721-x6f26ahr 2265 19 . . . cord-028721-x6f26ahr 2266 1 983 983 CD cord-028721-x6f26ahr 2266 2 Similar similar JJ cord-028721-x6f26ahr 2266 3 cells cell NNS cord-028721-x6f26ahr 2266 4 with with IN cord-028721-x6f26ahr 2266 5 fewer few JJR cord-028721-x6f26ahr 2266 6 nuclei nucleus NNS cord-028721-x6f26ahr 2266 7 have have VBP cord-028721-x6f26ahr 2266 8 also also RB cord-028721-x6f26ahr 2266 9 been be VBN cord-028721-x6f26ahr 2266 10 reported report VBN cord-028721-x6f26ahr 2266 11 in in IN cord-028721-x6f26ahr 2266 12 infertility infertility NN cord-028721-x6f26ahr 2266 13 due due IN cord-028721-x6f26ahr 2266 14 to to IN cord-028721-x6f26ahr 2266 15 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2266 16 , , , cord-028721-x6f26ahr 2266 17 984 984 CD cord-028721-x6f26ahr 2266 18 hyperprolactinemia hyperprolactinemia NN cord-028721-x6f26ahr 2266 19 , , , cord-028721-x6f26ahr 2266 20 and and CC cord-028721-x6f26ahr 2266 21 idiopathic idiopathic JJ cord-028721-x6f26ahr 2266 22 infertility infertility NN cord-028721-x6f26ahr 2266 23 ( ( -LRB- cord-028721-x6f26ahr 2266 24 Fig Fig NNP cord-028721-x6f26ahr 2266 25 . . . cord-028721-x6f26ahr 2266 26 _SP cord-028721-x6f26ahr 2267 1 12 12 CD cord-028721-x6f26ahr 2267 2 - - SYM cord-028721-x6f26ahr 2267 3 111 111 CD cord-028721-x6f26ahr 2267 4 ) ) -RRB- cord-028721-x6f26ahr 2267 5 . . . cord-028721-x6f26ahr 2268 1 There there EX cord-028721-x6f26ahr 2268 2 are be VBP cord-028721-x6f26ahr 2268 3 at at RB cord-028721-x6f26ahr 2268 4 least least RBS cord-028721-x6f26ahr 2268 5 four four CD cord-028721-x6f26ahr 2268 6 teratozoospermic teratozoospermic JJ cord-028721-x6f26ahr 2268 7 syndromes syndrome NNS cord-028721-x6f26ahr 2268 8 that that WDT cord-028721-x6f26ahr 2268 9 may may MD cord-028721-x6f26ahr 2268 10 be be VB cord-028721-x6f26ahr 2268 11 easily easily RB cord-028721-x6f26ahr 2268 12 identifi identifi VBN cord-028721-x6f26ahr 2268 13 ed ed NN cord-028721-x6f26ahr 2268 14 by by IN cord-028721-x6f26ahr 2268 15 testicular testicular JJ cord-028721-x6f26ahr 2268 16 biopsy biopsy NN cord-028721-x6f26ahr 2268 17 , , , cord-028721-x6f26ahr 2268 18 although although IN cord-028721-x6f26ahr 2268 19 in in IN cord-028721-x6f26ahr 2268 20 most most JJS cord-028721-x6f26ahr 2268 21 the the DT cord-028721-x6f26ahr 2268 22 diagnosis diagnosis NN cord-028721-x6f26ahr 2268 23 previously previously RB cord-028721-x6f26ahr 2268 24 relied rely VBD cord-028721-x6f26ahr 2268 25 on on IN cord-028721-x6f26ahr 2268 26 morphologic morphologic JJ cord-028721-x6f26ahr 2268 27 study study NN cord-028721-x6f26ahr 2268 28 of of IN cord-028721-x6f26ahr 2268 29 the the DT cord-028721-x6f26ahr 2268 30 spermiogram spermiogram NNP cord-028721-x6f26ahr 2268 31 : : : cord-028721-x6f26ahr 2268 32 ( ( -LRB- cord-028721-x6f26ahr 2268 33 1 1 LS cord-028721-x6f26ahr 2268 34 ) ) -RRB- cord-028721-x6f26ahr 2268 35 round round RB cord-028721-x6f26ahr 2268 36 - - HYPH cord-028721-x6f26ahr 2268 37 headed headed JJ cord-028721-x6f26ahr 2268 38 spermatids spermatid NNS cord-028721-x6f26ahr 2268 39 ( ( -LRB- cord-028721-x6f26ahr 2268 40 characteristic characteristic NN cord-028721-x6f26ahr 2268 41 of of IN cord-028721-x6f26ahr 2268 42 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 2268 43 lacking lack VBG cord-028721-x6f26ahr 2268 44 acrosomes acrosome NNS cord-028721-x6f26ahr 2268 45 ) ) -RRB- cord-028721-x6f26ahr 2269 1 ( ( -LRB- cord-028721-x6f26ahr 2269 2 Fig Fig NNP cord-028721-x6f26ahr 2269 3 . . . cord-028721-x6f26ahr 2270 1 12 12 CD cord-028721-x6f26ahr 2270 2 - - SYM cord-028721-x6f26ahr 2270 3 112 112 CD cord-028721-x6f26ahr 2270 4 ) ) -RRB- cord-028721-x6f26ahr 2270 5 , , , cord-028721-x6f26ahr 2270 6 ( ( -LRB- cord-028721-x6f26ahr 2270 7 2 2 LS cord-028721-x6f26ahr 2270 8 ) ) -RRB- cord-028721-x6f26ahr 2270 9 S s NN cord-028721-x6f26ahr 2270 10 c c NN cord-028721-x6f26ahr 2270 11 + + CC cord-028721-x6f26ahr 2270 12 S s NN cord-028721-x6f26ahr 2270 13 d d NN cord-028721-x6f26ahr 2270 14 spermatids spermatid NNS cord-028721-x6f26ahr 2270 15 with with IN cord-028721-x6f26ahr 2270 16 a a DT cord-028721-x6f26ahr 2270 17 very very RB cord-028721-x6f26ahr 2270 18 elongated elongated JJ cord-028721-x6f26ahr 2270 19 head head NN cord-028721-x6f26ahr 2270 20 ( ( -LRB- cord-028721-x6f26ahr 2270 21 characteristic characteristic NN cord-028721-x6f26ahr 2270 22 of of IN cord-028721-x6f26ahr 2270 23 varicocele varicocele NN cord-028721-x6f26ahr 2270 24 ) ) -RRB- cord-028721-x6f26ahr 2271 1 ( ( -LRB- cord-028721-x6f26ahr 2271 2 Fig Fig NNP cord-028721-x6f26ahr 2271 3 . . . cord-028721-x6f26ahr 2272 1 12 12 CD cord-028721-x6f26ahr 2272 2 - - SYM cord-028721-x6f26ahr 2272 3 113 113 CD cord-028721-x6f26ahr 2272 4 ) ) -RRB- cord-028721-x6f26ahr 2272 5 , , , cord-028721-x6f26ahr 2272 6 ( ( -LRB- cord-028721-x6f26ahr 2272 7 3 3 LS cord-028721-x6f26ahr 2272 8 ) ) -RRB- cord-028721-x6f26ahr 2272 9 macrocephalic macrocephalic NNP cord-028721-x6f26ahr 2272 10 S S NNP cord-028721-x6f26ahr 2272 11 c c NN cord-028721-x6f26ahr 2272 12 + + CC cord-028721-x6f26ahr 2272 13 S s NN cord-028721-x6f26ahr 2272 14 d d NN cord-028721-x6f26ahr 2272 15 spermatids spermatid NNS cord-028721-x6f26ahr 2273 1 whose whose WP$ cord-028721-x6f26ahr 2273 2 DNA dna NN cord-028721-x6f26ahr 2273 3 content content NN cord-028721-x6f26ahr 2273 4 suggests suggest VBZ cord-028721-x6f26ahr 2273 5 an an DT cord-028721-x6f26ahr 2273 6 anomaly anomaly NN cord-028721-x6f26ahr 2273 7 in in IN cord-028721-x6f26ahr 2273 8 the the DT cord-028721-x6f26ahr 2273 9 fi fi NNP cord-028721-x6f26ahr 2273 10 rst rst NNP cord-028721-x6f26ahr 2273 11 meiotic meiotic JJ cord-028721-x6f26ahr 2273 12 division division NN cord-028721-x6f26ahr 2273 13 , , , cord-028721-x6f26ahr 2273 14 and and CC cord-028721-x6f26ahr 2274 1 ( ( -LRB- cord-028721-x6f26ahr 2274 2 4 4 LS cord-028721-x6f26ahr 2274 3 ) ) -RRB- cord-028721-x6f26ahr 2274 4 S s NN cord-028721-x6f26ahr 2274 5 c c NN cord-028721-x6f26ahr 2274 6 + + CC cord-028721-x6f26ahr 2275 1 S S NNP cord-028721-x6f26ahr 2275 2 d d IN cord-028721-x6f26ahr 2275 3 spermatids spermatid NNS cord-028721-x6f26ahr 2275 4 with with IN cord-028721-x6f26ahr 2275 5 voluminous voluminous JJ cord-028721-x6f26ahr 2275 6 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 2275 7 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2275 8 droplets droplet NNS cord-028721-x6f26ahr 2275 9 ( ( -LRB- cord-028721-x6f26ahr 2275 10 syndrome syndrome NN cord-028721-x6f26ahr 2275 11 of of IN cord-028721-x6f26ahr 2275 12 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2275 13 with with IN cord-028721-x6f26ahr 2275 14 short short JJ cord-028721-x6f26ahr 2275 15 thick thick NNP cord-028721-x6f26ahr 2275 16 fl fl NNP cord-028721-x6f26ahr 2275 17 agella agella NNP cord-028721-x6f26ahr 2275 18 985 985 CD cord-028721-x6f26ahr 2275 19 or or CC cord-028721-x6f26ahr 2275 20 fi fi IN cord-028721-x6f26ahr 2275 21 brous brous JJ cord-028721-x6f26ahr 2275 22 sheath sheath NN cord-028721-x6f26ahr 2275 23 dysplasia dysplasia NN cord-028721-x6f26ahr 2275 24 ) ) -RRB- cord-028721-x6f26ahr 2275 25 . . . cord-028721-x6f26ahr 2276 1 In in IN cord-028721-x6f26ahr 2276 2 some some DT cord-028721-x6f26ahr 2276 3 patients patient NNS cord-028721-x6f26ahr 2276 4 , , , cord-028721-x6f26ahr 2276 5 S S NNP cord-028721-x6f26ahr 2276 6 a a DT cord-028721-x6f26ahr 2276 7 + + CC cord-028721-x6f26ahr 2276 8 S s NN cord-028721-x6f26ahr 2276 9 b b NN cord-028721-x6f26ahr 2276 10 spermatids spermatids NNP cord-028721-x6f26ahr 2276 11 rest rest NN cord-028721-x6f26ahr 2276 12 in in IN cord-028721-x6f26ahr 2276 13 these these DT cord-028721-x6f26ahr 2276 14 initial initial JJ cord-028721-x6f26ahr 2276 15 phases phase NNS cord-028721-x6f26ahr 2276 16 of of IN cord-028721-x6f26ahr 2276 17 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 2276 18 and and CC cord-028721-x6f26ahr 2276 19 eventually eventually RB cord-028721-x6f26ahr 2276 20 become become VB cord-028721-x6f26ahr 2276 21 sloughed slough VBN cord-028721-x6f26ahr 2276 22 in in IN cord-028721-x6f26ahr 2276 23 the the DT cord-028721-x6f26ahr 2276 24 tubular tubular JJ cord-028721-x6f26ahr 2276 25 lumina lumina NNP cord-028721-x6f26ahr 2276 26 . . . cord-028721-x6f26ahr 2277 1 986 986 CD cord-028721-x6f26ahr 2278 1 In in IN cord-028721-x6f26ahr 2278 2 other other JJ cord-028721-x6f26ahr 2278 3 testes testis NNS cord-028721-x6f26ahr 2278 4 there there EX cord-028721-x6f26ahr 2278 5 are be VBP cord-028721-x6f26ahr 2278 6 macrocephalic macrocephalic NNP cord-028721-x6f26ahr 2278 7 S S NNP cord-028721-x6f26ahr 2278 8 c c NN cord-028721-x6f26ahr 2278 9 and and CC cord-028721-x6f26ahr 2278 10 S S NNP cord-028721-x6f26ahr 2278 11 d d NNP cord-028721-x6f26ahr 2278 12 spermatids spermatids NNP cord-028721-x6f26ahr 2278 13 with with IN cord-028721-x6f26ahr 2278 14 anomalous anomalous JJ cord-028721-x6f26ahr 2278 15 DNA dna NN cord-028721-x6f26ahr 2278 16 content content NN cord-028721-x6f26ahr 2278 17 , , , cord-028721-x6f26ahr 2278 18 suggesting suggest VBG cord-028721-x6f26ahr 2278 19 an an DT cord-028721-x6f26ahr 2278 20 anomaly anomaly NN cord-028721-x6f26ahr 2278 21 in in IN cord-028721-x6f26ahr 2278 22 the the DT cord-028721-x6f26ahr 2278 23 fi fi NNP cord-028721-x6f26ahr 2278 24 rst rst NNP cord-028721-x6f26ahr 2278 25 meiotic meiotic JJ cord-028721-x6f26ahr 2278 26 division division NN cord-028721-x6f26ahr 2278 27 . . . cord-028721-x6f26ahr 2279 1 Ultrastructural ultrastructural JJ cord-028721-x6f26ahr 2279 2 study study NN cord-028721-x6f26ahr 2279 3 of of IN cord-028721-x6f26ahr 2279 4 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2279 5 is be VBZ cord-028721-x6f26ahr 2279 6 sometimes sometimes RB cord-028721-x6f26ahr 2279 7 necessary necessary JJ cord-028721-x6f26ahr 2279 8 to to TO cord-028721-x6f26ahr 2279 9 determine determine VB cord-028721-x6f26ahr 2279 10 the the DT cord-028721-x6f26ahr 2279 11 cause cause NN cord-028721-x6f26ahr 2279 12 of of IN cord-028721-x6f26ahr 2279 13 male male JJ cord-028721-x6f26ahr 2279 14 infertility infertility NN cord-028721-x6f26ahr 2279 15 . . . cord-028721-x6f26ahr 2280 1 A a DT cord-028721-x6f26ahr 2280 2 number number NN cord-028721-x6f26ahr 2280 3 of of IN cord-028721-x6f26ahr 2280 4 mor mor JJ cord-028721-x6f26ahr 2280 5 - - JJ cord-028721-x6f26ahr 2280 6 phologically phologically JJ cord-028721-x6f26ahr 2280 7 abnormal abnormal JJ cord-028721-x6f26ahr 2280 8 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2280 9 are be VBP cord-028721-x6f26ahr 2280 10 present present JJ cord-028721-x6f26ahr 2280 11 in in IN cord-028721-x6f26ahr 2280 12 all all DT cord-028721-x6f26ahr 2280 13 semen semen NN cord-028721-x6f26ahr 2280 14 samples sample NNS cord-028721-x6f26ahr 2280 15 , , , cord-028721-x6f26ahr 2280 16 including include VBG cord-028721-x6f26ahr 2280 17 those those DT cord-028721-x6f26ahr 2280 18 from from IN cord-028721-x6f26ahr 2280 19 fertile fertile JJ cord-028721-x6f26ahr 2280 20 men man NNS cord-028721-x6f26ahr 2280 21 , , , cord-028721-x6f26ahr 2280 22 but but CC cord-028721-x6f26ahr 2280 23 abnormal abnormal JJ cord-028721-x6f26ahr 2280 24 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2280 25 are be VBP cord-028721-x6f26ahr 2280 26 very very RB cord-028721-x6f26ahr 2280 27 numerous numerous JJ cord-028721-x6f26ahr 2280 28 in in IN cord-028721-x6f26ahr 2280 29 infertile infertile JJ cord-028721-x6f26ahr 2280 30 patients patient NNS cord-028721-x6f26ahr 2280 31 . . . cord-028721-x6f26ahr 2281 1 Ultrastructural ultrastructural JJ cord-028721-x6f26ahr 2281 2 study study NN cord-028721-x6f26ahr 2281 3 is be VBZ cord-028721-x6f26ahr 2281 4 advised advise VBN cord-028721-x6f26ahr 2281 5 in in IN cord-028721-x6f26ahr 2281 6 all all DT cord-028721-x6f26ahr 2281 7 cases case NNS cord-028721-x6f26ahr 2281 8 of of IN cord-028721-x6f26ahr 2281 9 asthenozoospermia asthenozoospermia NN cord-028721-x6f26ahr 2281 10 , , , cord-028721-x6f26ahr 2281 11 in in IN cord-028721-x6f26ahr 2281 12 teratozoospermia teratozoospermia NN cord-028721-x6f26ahr 2281 13 when when WRB cord-028721-x6f26ahr 2281 14 the the DT cord-028721-x6f26ahr 2281 15 number number NN cord-028721-x6f26ahr 2281 16 of of IN cord-028721-x6f26ahr 2281 17 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2281 18 showing show VBG cord-028721-x6f26ahr 2281 19 the the DT cord-028721-x6f26ahr 2281 20 same same JJ cord-028721-x6f26ahr 2281 21 morphological morphological JJ cord-028721-x6f26ahr 2281 22 anomaly anomaly NN cord-028721-x6f26ahr 2281 23 is be VBZ cord-028721-x6f26ahr 2281 24 high high JJ cord-028721-x6f26ahr 2281 25 , , , cord-028721-x6f26ahr 2281 26 and and CC cord-028721-x6f26ahr 2281 27 in in IN cord-028721-x6f26ahr 2281 28 cases case NNS cord-028721-x6f26ahr 2281 29 with with IN cord-028721-x6f26ahr 2281 30 apparently apparently RB cord-028721-x6f26ahr 2281 31 normal normal JJ cord-028721-x6f26ahr 2281 32 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2281 33 that that WDT cord-028721-x6f26ahr 2281 34 fail fail VBP cord-028721-x6f26ahr 2281 35 to to TO cord-028721-x6f26ahr 2281 36 fertilize fertilize VB cord-028721-x6f26ahr 2281 37 in in IN cord-028721-x6f26ahr 2281 38 vitro vitro FW cord-028721-x6f26ahr 2281 39 . . . cord-028721-x6f26ahr 2282 1 987 987 CD cord-028721-x6f26ahr 2283 1 The the DT cord-028721-x6f26ahr 2283 2 classifi classifi NN cord-028721-x6f26ahr 2283 3 cation cation NN cord-028721-x6f26ahr 2283 4 of of IN cord-028721-x6f26ahr 2283 5 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 2283 6 anomalies anomaly NNS cord-028721-x6f26ahr 2283 7 in in IN cord-028721-x6f26ahr 2283 8 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2283 9 is be VBZ cord-028721-x6f26ahr 2283 10 based base VBN cord-028721-x6f26ahr 2283 11 on on IN cord-028721-x6f26ahr 2283 12 light light JJ cord-028721-x6f26ahr 2283 13 microscopy microscopy NNS cord-028721-x6f26ahr 2283 14 fi fi NN cord-028721-x6f26ahr 2283 15 ndings nding NNS cord-028721-x6f26ahr 2283 16 988 988 CD cord-028721-x6f26ahr 2283 17 of of IN cord-028721-x6f26ahr 2283 18 lesions lesion NNS cord-028721-x6f26ahr 2283 19 in in IN cord-028721-x6f26ahr 2283 20 the the DT cord-028721-x6f26ahr 2283 21 head head NN cord-028721-x6f26ahr 2283 22 and and CC cord-028721-x6f26ahr 2283 23 tail tail NN cord-028721-x6f26ahr 2283 24 . . . cord-028721-x6f26ahr 2284 1 Anomalies anomaly NNS cord-028721-x6f26ahr 2284 2 of of IN cord-028721-x6f26ahr 2284 3 the the DT cord-028721-x6f26ahr 2284 4 spermatozoal spermatozoal NNP cord-028721-x6f26ahr 2284 5 head head NN cord-028721-x6f26ahr 2285 1 These these DT cord-028721-x6f26ahr 2285 2 are be VBP cord-028721-x6f26ahr 2285 3 defi defi NNP cord-028721-x6f26ahr 2285 4 ned ned NNP cord-028721-x6f26ahr 2285 5 by by IN cord-028721-x6f26ahr 2285 6 changes change NNS cord-028721-x6f26ahr 2285 7 in in IN cord-028721-x6f26ahr 2285 8 the the DT cord-028721-x6f26ahr 2285 9 shape shape NN cord-028721-x6f26ahr 2285 10 of of IN cord-028721-x6f26ahr 2285 11 the the DT cord-028721-x6f26ahr 2285 12 head head NN cord-028721-x6f26ahr 2285 13 , , , cord-028721-x6f26ahr 2285 14 and and CC cord-028721-x6f26ahr 2285 15 usually usually RB cord-028721-x6f26ahr 2285 16 involve involve VBP cord-028721-x6f26ahr 2285 17 both both CC cord-028721-x6f26ahr 2285 18 the the DT cord-028721-x6f26ahr 2285 19 nucleus nucleus NN cord-028721-x6f26ahr 2285 20 and and CC cord-028721-x6f26ahr 2285 21 the the DT cord-028721-x6f26ahr 2285 22 acrosome acrosome NN cord-028721-x6f26ahr 2285 23 . . . cord-028721-x6f26ahr 2286 1 Some some DT cord-028721-x6f26ahr 2286 2 anomalies anomaly NNS cord-028721-x6f26ahr 2286 3 , , , cord-028721-x6f26ahr 2286 4 such such JJ cord-028721-x6f26ahr 2286 5 as as IN cord-028721-x6f26ahr 2286 6 pear pear NN cord-028721-x6f26ahr 2286 7 - - HYPH cord-028721-x6f26ahr 2286 8 shaped shaped JJ cord-028721-x6f26ahr 2286 9 , , , cord-028721-x6f26ahr 2286 10 candle candle NN cord-028721-x6f26ahr 2286 11 - - HYPH cord-028721-x6f26ahr 2286 12 shaped shape VBN cord-028721-x6f26ahr 2286 13 , , , cord-028721-x6f26ahr 2286 14 or or CC cord-028721-x6f26ahr 2286 15 egg egg NN cord-028721-x6f26ahr 2286 16 - - HYPH cord-028721-x6f26ahr 2286 17 shaped shape VBN cord-028721-x6f26ahr 2286 18 heads head NNS cord-028721-x6f26ahr 2286 19 , , , cord-028721-x6f26ahr 2286 20 989,990 989,990 CD cord-028721-x6f26ahr 2286 21 are be VBP cord-028721-x6f26ahr 2286 22 regarded regard VBN cord-028721-x6f26ahr 2286 23 as as IN cord-028721-x6f26ahr 2286 24 minor minor JJ cord-028721-x6f26ahr 2286 25 variants variant NNS cord-028721-x6f26ahr 2286 26 of of IN cord-028721-x6f26ahr 2286 27 normal normal JJ cord-028721-x6f26ahr 2286 28 . . . cord-028721-x6f26ahr 2287 1 More More JJR cord-028721-x6f26ahr 2287 2 signifi signifi NNP cord-028721-x6f26ahr 2287 3 ca can MD cord-028721-x6f26ahr 2287 4 nt not RB cord-028721-x6f26ahr 2287 5 abnormalities abnormality NNS cord-028721-x6f26ahr 2287 6 are be VBP cord-028721-x6f26ahr 2287 7 the the DT cord-028721-x6f26ahr 2287 8 elongated elongated JJ cord-028721-x6f26ahr 2287 9 , , , cord-028721-x6f26ahr 2287 10 microcephalic microcephalic JJ cord-028721-x6f26ahr 2287 11 , , , cord-028721-x6f26ahr 2287 12 macrocephalic macrocephalic JJ cord-028721-x6f26ahr 2287 13 , , , cord-028721-x6f26ahr 2287 14 and and CC cord-028721-x6f26ahr 2287 15 crater crater NN cord-028721-x6f26ahr 2287 16 - - HYPH cord-028721-x6f26ahr 2287 17 defect defect NN cord-028721-x6f26ahr 2287 18 forms form NNS cord-028721-x6f26ahr 2287 19 . . . cord-028721-x6f26ahr 2288 1 The the DT cord-028721-x6f26ahr 2288 2 most most RBS cord-028721-x6f26ahr 2288 3 frequent frequent JJ cord-028721-x6f26ahr 2288 4 abnormal abnormal JJ cord-028721-x6f26ahr 2288 5 head head NN cord-028721-x6f26ahr 2288 6 shape shape NN cord-028721-x6f26ahr 2288 7 is be VBZ cord-028721-x6f26ahr 2288 8 elongated elongated JJ cord-028721-x6f26ahr 2288 9 with with IN cord-028721-x6f26ahr 2288 10 a a DT cord-028721-x6f26ahr 2288 11 narrow narrow JJ cord-028721-x6f26ahr 2288 12 base base NN cord-028721-x6f26ahr 2288 13 ( ( -LRB- cord-028721-x6f26ahr 2288 14 tapered tapered JJ cord-028721-x6f26ahr 2288 15 head head NN cord-028721-x6f26ahr 2288 16 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2288 17 ) ) -RRB- cord-028721-x6f26ahr 2288 18 . . . cord-028721-x6f26ahr 2289 1 This this DT cord-028721-x6f26ahr 2289 2 anomaly anomaly NN cord-028721-x6f26ahr 2289 3 is be VBZ cord-028721-x6f26ahr 2289 4 frequently frequently RB cord-028721-x6f26ahr 2289 5 associated associate VBN cord-028721-x6f26ahr 2289 6 with with IN cord-028721-x6f26ahr 2289 7 varicocele varicocele NN cord-028721-x6f26ahr 2289 8 . . . cord-028721-x6f26ahr 2290 1 991 991 CD cord-028721-x6f26ahr 2291 1 Microcephalic Microcephalic NNP cord-028721-x6f26ahr 2291 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2291 3 have have VBP cord-028721-x6f26ahr 2291 4 spherical spherical JJ cord-028721-x6f26ahr 2291 5 ( ( -LRB- cord-028721-x6f26ahr 2291 6 globozoospermia globozoospermia NN cord-028721-x6f26ahr 2291 7 ) ) -RRB- cord-028721-x6f26ahr 2291 8 or or CC cord-028721-x6f26ahr 2291 9 irregularly irregularly RB cord-028721-x6f26ahr 2291 10 shaped shape VBN cord-028721-x6f26ahr 2291 11 heads head NNS cord-028721-x6f26ahr 2291 12 . . . cord-028721-x6f26ahr 2292 1 The the DT cord-028721-x6f26ahr 2292 2 former former JJ cord-028721-x6f26ahr 2292 3 have have VBP cord-028721-x6f26ahr 2292 4 spherical spherical JJ cord-028721-x6f26ahr 2292 5 nuclei nucleus NNS cord-028721-x6f26ahr 2292 6 with with IN cord-028721-x6f26ahr 2292 7 poorly poorly RB cord-028721-x6f26ahr 2292 8 condensed condense VBN cord-028721-x6f26ahr 2292 9 chromatin chromatin NN cord-028721-x6f26ahr 2292 10 and and CC cord-028721-x6f26ahr 2292 11 lack lack NN cord-028721-x6f26ahr 2292 12 acrosomes acrosome NNS cord-028721-x6f26ahr 2292 13 , , , cord-028721-x6f26ahr 2292 14 postacrosomal postacrosomal JJ cord-028721-x6f26ahr 2292 15 sheaths sheath NNS cord-028721-x6f26ahr 2292 16 , , , cord-028721-x6f26ahr 2292 17 and and CC cord-028721-x6f26ahr 2292 18 a a DT cord-028721-x6f26ahr 2292 19 nuclear nuclear JJ cord-028721-x6f26ahr 2292 20 ring ring NN cord-028721-x6f26ahr 2292 21 ( ( -LRB- cord-028721-x6f26ahr 2292 22 Fig fig NN cord-028721-x6f26ahr 2292 23 . . . cord-028721-x6f26ahr 2292 24 _SP cord-028721-x6f26ahr 2292 25 12 12 CD cord-028721-x6f26ahr 2292 26 - - SYM cord-028721-x6f26ahr 2292 27 114 114 CD cord-028721-x6f26ahr 2292 28 ) ) -RRB- cord-028721-x6f26ahr 2292 29 . . . cord-028721-x6f26ahr 2293 1 Most Most JJS cord-028721-x6f26ahr 2293 2 cases case NNS cord-028721-x6f26ahr 2293 3 are be VBP cord-028721-x6f26ahr 2293 4 sporadic sporadic JJ cord-028721-x6f26ahr 2293 5 , , , cord-028721-x6f26ahr 2293 6 but but CC cord-028721-x6f26ahr 2293 7 this this DT cord-028721-x6f26ahr 2293 8 lesion lesion NN cord-028721-x6f26ahr 2293 9 was be VBD cord-028721-x6f26ahr 2293 10 also also RB cord-028721-x6f26ahr 2293 11 reported report VBN cord-028721-x6f26ahr 2293 12 in in IN cord-028721-x6f26ahr 2293 13 two two CD cord-028721-x6f26ahr 2293 14 pairs pair NNS cord-028721-x6f26ahr 2293 15 of of IN cord-028721-x6f26ahr 2293 16 infertile infertile JJ cord-028721-x6f26ahr 2293 17 brothers brother NNS cord-028721-x6f26ahr 2293 18 . . . cord-028721-x6f26ahr 2294 1 992 992 CD cord-028721-x6f26ahr 2294 2 , , , cord-028721-x6f26ahr 2294 3 993 993 CD cord-028721-x6f26ahr 2294 4 Microcephalic Microcephalic NNP cord-028721-x6f26ahr 2294 5 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2294 6 with with IN cord-028721-x6f26ahr 2294 7 irregularly irregularly RB cord-028721-x6f26ahr 2294 8 shaped shape VBN cord-028721-x6f26ahr 2294 9 heads head NNS cord-028721-x6f26ahr 2294 10 have have VBP cord-028721-x6f26ahr 2294 11 small small JJ cord-028721-x6f26ahr 2294 12 and and CC cord-028721-x6f26ahr 2294 13 irregularly irregularly RB cord-028721-x6f26ahr 2294 14 shaped shape VBN cord-028721-x6f26ahr 2294 15 acrosomes acrosome NNS cord-028721-x6f26ahr 2294 16 that that WDT cord-028721-x6f26ahr 2294 17 usually usually RB cord-028721-x6f26ahr 2294 18 are be VBP cord-028721-x6f26ahr 2294 19 not not RB cord-028721-x6f26ahr 2294 20 in in IN cord-028721-x6f26ahr 2294 21 contact contact NN cord-028721-x6f26ahr 2294 22 with with IN cord-028721-x6f26ahr 2294 23 the the DT cord-028721-x6f26ahr 2294 24 nucleus nucleus NN cord-028721-x6f26ahr 2294 25 . . . cord-028721-x6f26ahr 2295 1 This this DT cord-028721-x6f26ahr 2295 2 anomaly anomaly NN cord-028721-x6f26ahr 2295 3 may may MD cord-028721-x6f26ahr 2295 4 be be VB cord-028721-x6f26ahr 2295 5 congenital congenital JJ cord-028721-x6f26ahr 2295 6 , , , cord-028721-x6f26ahr 2295 7 as as IN cord-028721-x6f26ahr 2295 8 in in IN cord-028721-x6f26ahr 2295 9 Aarskog Aarskog NNP cord-028721-x6f26ahr 2295 10 - - HYPH cord-028721-x6f26ahr 2295 11 Scott Scott NNP cord-028721-x6f26ahr 2295 12 syndrome syndrome NN cord-028721-x6f26ahr 2295 13 , , , cord-028721-x6f26ahr 2295 14 994 994 CD cord-028721-x6f26ahr 2295 15 or or CC cord-028721-x6f26ahr 2295 16 secondary secondary JJ cord-028721-x6f26ahr 2295 17 to to TO cord-028721-x6f26ahr 2295 18 heat heat VB cord-028721-x6f26ahr 2295 19 exposure exposure NN cord-028721-x6f26ahr 2295 20 or or CC cord-028721-x6f26ahr 2295 21 hashish hashish NN cord-028721-x6f26ahr 2295 22 smoking smoking NN cord-028721-x6f26ahr 2295 23 . . . cord-028721-x6f26ahr 2296 1 In in IN cord-028721-x6f26ahr 2296 2 both both DT cord-028721-x6f26ahr 2296 3 types type NNS cord-028721-x6f26ahr 2296 4 of of IN cord-028721-x6f26ahr 2296 5 microcephaly microcephaly NNS cord-028721-x6f26ahr 2296 6 loss loss NN cord-028721-x6f26ahr 2296 7 of of IN cord-028721-x6f26ahr 2296 8 connection connection NN cord-028721-x6f26ahr 2296 9 between between IN cord-028721-x6f26ahr 2296 10 the the DT cord-028721-x6f26ahr 2296 11 acrosomal acrosomal JJ cord-028721-x6f26ahr 2296 12 vesicle vesicle NN cord-028721-x6f26ahr 2296 13 and and CC cord-028721-x6f26ahr 2296 14 the the DT cord-028721-x6f26ahr 2296 15 spermatozoal spermatozoal NNP cord-028721-x6f26ahr 2296 16 head head NN cord-028721-x6f26ahr 2296 17 is be VBZ cord-028721-x6f26ahr 2296 18 attributed attribute VBN cord-028721-x6f26ahr 2296 19 to to IN cord-028721-x6f26ahr 2296 20 a a DT cord-028721-x6f26ahr 2296 21 defi defi NNP cord-028721-x6f26ahr 2296 22 ciency ciency NN cord-028721-x6f26ahr 2296 23 in in IN cord-028721-x6f26ahr 2296 24 basic basic JJ cord-028721-x6f26ahr 2296 25 proteins protein NNS cord-028721-x6f26ahr 2296 26 of of IN cord-028721-x6f26ahr 2296 27 the the DT cord-028721-x6f26ahr 2296 28 sperm sperm NN cord-028721-x6f26ahr 2296 29 perinuclear perinuclear NNP cord-028721-x6f26ahr 2296 30 theca theca NNP cord-028721-x6f26ahr 2296 31 that that WDT cord-028721-x6f26ahr 2296 32 promotes promote VBZ cord-028721-x6f26ahr 2296 33 nuclear nuclear JJ cord-028721-x6f26ahr 2296 34 envelope envelope NN cord-028721-x6f26ahr 2296 35 organization organization NN cord-028721-x6f26ahr 2296 36 and and CC cord-028721-x6f26ahr 2296 37 adhesion adhesion NN cord-028721-x6f26ahr 2296 38 of of IN cord-028721-x6f26ahr 2296 39 the the DT cord-028721-x6f26ahr 2296 40 acrosomal acrosomal JJ cord-028721-x6f26ahr 2296 41 vesicle vesicle NN cord-028721-x6f26ahr 2296 42 . . . cord-028721-x6f26ahr 2297 1 995 995 CD cord-028721-x6f26ahr 2297 2 Acrosin Acrosin NNP cord-028721-x6f26ahr 2297 3 is be VBZ cord-028721-x6f26ahr 2297 4 reduced reduce VBN cord-028721-x6f26ahr 2297 5 or or CC cord-028721-x6f26ahr 2297 6 absent absent JJ cord-028721-x6f26ahr 2297 7 in in IN cord-028721-x6f26ahr 2297 8 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 2297 9 lacking lack VBG cord-028721-x6f26ahr 2297 10 acrosomes acrosome NNS cord-028721-x6f26ahr 2297 11 and and CC cord-028721-x6f26ahr 2297 12 those those DT cord-028721-x6f26ahr 2297 13 with with IN cord-028721-x6f26ahr 2297 14 small small JJ cord-028721-x6f26ahr 2297 15 acrosomes acrosome NNS cord-028721-x6f26ahr 2297 16 . . . cord-028721-x6f26ahr 2298 1 996 996 CD cord-028721-x6f26ahr 2298 2 Motility motility NN cord-028721-x6f26ahr 2298 3 may may MD cord-028721-x6f26ahr 2298 4 be be VB cord-028721-x6f26ahr 2298 5 Infertility Infertility NNP cord-028721-x6f26ahr 2298 6 normal normal JJ cord-028721-x6f26ahr 2298 7 . . . cord-028721-x6f26ahr 2299 1 The the DT cord-028721-x6f26ahr 2299 2 occurrence occurrence NN cord-028721-x6f26ahr 2299 3 of of IN cord-028721-x6f26ahr 2299 4 aneuploidy aneuploidy NN cord-028721-x6f26ahr 2299 5 997 997 CD cord-028721-x6f26ahr 2299 6 and and CC cord-028721-x6f26ahr 2299 7 disomy disomy NN cord-028721-x6f26ahr 2299 8 of of IN cord-028721-x6f26ahr 2299 9 sex sex NN cord-028721-x6f26ahr 2299 10 chromosomes chromosome NNS cord-028721-x6f26ahr 2299 11 998 998 CD cord-028721-x6f26ahr 2299 12 , , , cord-028721-x6f26ahr 2299 13 999 999 CD cord-028721-x6f26ahr 2299 14 in in IN cord-028721-x6f26ahr 2299 15 some some DT cord-028721-x6f26ahr 2299 16 cases case NNS cord-028721-x6f26ahr 2299 17 should should MD cord-028721-x6f26ahr 2299 18 be be VB cord-028721-x6f26ahr 2299 19 evaluated evaluate VBN cord-028721-x6f26ahr 2299 20 before before IN cord-028721-x6f26ahr 2299 21 performing perform VBG cord-028721-x6f26ahr 2299 22 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 2299 23 sperm sperm NN cord-028721-x6f26ahr 2299 24 injection injection NN cord-028721-x6f26ahr 2299 25 ( ( -LRB- cord-028721-x6f26ahr 2299 26 ICSI ICSI NNP cord-028721-x6f26ahr 2299 27 ) ) -RRB- cord-028721-x6f26ahr 2299 28 . . . cord-028721-x6f26ahr 2300 1 The the DT cord-028721-x6f26ahr 2300 2 cause cause NN cord-028721-x6f26ahr 2300 3 of of IN cord-028721-x6f26ahr 2300 4 round round NN cord-028721-x6f26ahr 2300 5 - - HYPH cord-028721-x6f26ahr 2300 6 headed headed JJ cord-028721-x6f26ahr 2300 7 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2300 8 might may MD cord-028721-x6f26ahr 2300 9 be be VB cord-028721-x6f26ahr 2300 10 the the DT cord-028721-x6f26ahr 2300 11 lack lack NN cord-028721-x6f26ahr 2300 12 of of IN cord-028721-x6f26ahr 2300 13 Golgi Golgi NNP cord-028721-x6f26ahr 2300 14 - - HYPH cord-028721-x6f26ahr 2300 15 associated associate VBN cord-028721-x6f26ahr 2300 16 protein protein NN cord-028721-x6f26ahr 2300 17 known know VBN cord-028721-x6f26ahr 2300 18 in in IN cord-028721-x6f26ahr 2300 19 male male JJ cord-028721-x6f26ahr 2300 20 mice mouse NNS cord-028721-x6f26ahr 2300 21 as as IN cord-028721-x6f26ahr 2300 22 Golgi Golgi NNP cord-028721-x6f26ahr 2300 23 - - HYPH cord-028721-x6f26ahr 2300 24 associated associate VBN cord-028721-x6f26ahr 2300 25 PDZ PDZ NNP cord-028721-x6f26ahr 2300 26 - - : cord-028721-x6f26ahr 2300 27 and and CC cord-028721-x6f26ahr 2300 28 coiled coil VBN cord-028721-x6f26ahr 2300 29 - - HYPH cord-028721-x6f26ahr 2300 30 coil coil NN cord-028721-x6f26ahr 2300 31 motif motif NN cord-028721-x6f26ahr 2300 32 - - HYPH cord-028721-x6f26ahr 2300 33 containing contain VBG cord-028721-x6f26ahr 2300 34 protein protein NN cord-028721-x6f26ahr 2300 35 ( ( -LRB- cord-028721-x6f26ahr 2300 36 GOPC GOPC NNP cord-028721-x6f26ahr 2300 37 ) ) -RRB- cord-028721-x6f26ahr 2300 38 . . . cord-028721-x6f26ahr 2301 1 This this DT cord-028721-x6f26ahr 2301 2 protein protein NN cord-028721-x6f26ahr 2301 3 is be VBZ cord-028721-x6f26ahr 2301 4 principally principally RB cord-028721-x6f26ahr 2301 5 localized localize VBN cord-028721-x6f26ahr 2301 6 in in IN cord-028721-x6f26ahr 2301 7 the the DT cord-028721-x6f26ahr 2301 8 trans trans JJ cord-028721-x6f26ahr 2301 9 - - NNP cord-028721-x6f26ahr 2301 10 Golgi Golgi NNP cord-028721-x6f26ahr 2301 11 region region NN cord-028721-x6f26ahr 2301 12 in in IN cord-028721-x6f26ahr 2301 13 round round JJ cord-028721-x6f26ahr 2301 14 spermatids spermatid NNS cord-028721-x6f26ahr 2301 15 , , , cord-028721-x6f26ahr 2301 16 and and CC cord-028721-x6f26ahr 2301 17 its -PRON- PRP$ cord-028721-x6f26ahr 2301 18 loss loss NN cord-028721-x6f26ahr 2301 19 produces produce VBZ cord-028721-x6f26ahr 2301 20 globozoospermia globozoospermia NN cord-028721-x6f26ahr 2301 21 . . . cord-028721-x6f26ahr 2302 1 The the DT cord-028721-x6f26ahr 2302 2 primary primary JJ cord-028721-x6f26ahr 2302 3 defect defect NN cord-028721-x6f26ahr 2302 4 consists consist VBZ cord-028721-x6f26ahr 2302 5 of of IN cord-028721-x6f26ahr 2302 6 an an DT cord-028721-x6f26ahr 2302 7 inability inability NN cord-028721-x6f26ahr 2302 8 of of IN cord-028721-x6f26ahr 2302 9 acrosomal acrosomal JJ cord-028721-x6f26ahr 2302 10 vesicles vesicle NNS cord-028721-x6f26ahr 2302 11 to to TO cord-028721-x6f26ahr 2302 12 fuse fuse VB cord-028721-x6f26ahr 2302 13 to to IN cord-028721-x6f26ahr 2302 14 each each DT cord-028721-x6f26ahr 2302 15 other other JJ cord-028721-x6f26ahr 2302 16 to to TO cord-028721-x6f26ahr 2302 17 create create VB cord-028721-x6f26ahr 2302 18 the the DT cord-028721-x6f26ahr 2302 19 acrosome acrosome NN cord-028721-x6f26ahr 2302 20 . . . cord-028721-x6f26ahr 2303 1 1000 1000 CD cord-028721-x6f26ahr 2303 2 Macrocephalic Macrocephalic NNP cord-028721-x6f26ahr 2303 3 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2303 4 ( ( -LRB- cord-028721-x6f26ahr 2303 5 macronuclear macronuclear NNP cord-028721-x6f26ahr 2303 6 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2303 7 ) ) -RRB- cord-028721-x6f26ahr 2303 8 have have VBP cord-028721-x6f26ahr 2303 9 enlarged enlarge VBN cord-028721-x6f26ahr 2303 10 , , , cord-028721-x6f26ahr 2303 11 irregularly irregularly RB cord-028721-x6f26ahr 2303 12 shaped shape VBN cord-028721-x6f26ahr 2303 13 heads head NNS cord-028721-x6f26ahr 2303 14 and and CC cord-028721-x6f26ahr 2303 15 defi defi NNP cord-028721-x6f26ahr 2303 16 cient cient NNP cord-028721-x6f26ahr 2303 17 chromatin chromatin NNP cord-028721-x6f26ahr 2303 18 condensation condensation NN cord-028721-x6f26ahr 2303 19 . . . cord-028721-x6f26ahr 2304 1 There there EX cord-028721-x6f26ahr 2304 2 are be VBP cord-028721-x6f26ahr 2304 3 two two CD cord-028721-x6f26ahr 2304 4 types type NNS cord-028721-x6f26ahr 2304 5 ( ( -LRB- cord-028721-x6f26ahr 2304 6 multiple multiple JJ cord-028721-x6f26ahr 2304 7 tails tail NNS cord-028721-x6f26ahr 2304 8 1001 1001 CD cord-028721-x6f26ahr 2304 9 , , , cord-028721-x6f26ahr 2304 10 1002 1002 CD cord-028721-x6f26ahr 2304 11 and and CC cord-028721-x6f26ahr 2304 12 afl afl NNP cord-028721-x6f26ahr 2304 13 agellate agellate NNP cord-028721-x6f26ahr 2304 14 ) ) -RRB- cord-028721-x6f26ahr 2304 15 , , , cord-028721-x6f26ahr 2304 16 both both DT cord-028721-x6f26ahr 2304 17 of of IN cord-028721-x6f26ahr 2304 18 which which WDT cord-028721-x6f26ahr 2304 19 have have VBP cord-028721-x6f26ahr 2304 20 abnormal abnormal JJ cord-028721-x6f26ahr 2304 21 DNA dna NN cord-028721-x6f26ahr 2304 22 content content NN cord-028721-x6f26ahr 2304 23 ( ( -LRB- cord-028721-x6f26ahr 2304 24 many many JJ cord-028721-x6f26ahr 2304 25 are be VBP cord-028721-x6f26ahr 2304 26 tetraploid tetraploid JJ cord-028721-x6f26ahr 2304 27 ) ) -RRB- cord-028721-x6f26ahr 2304 28 , , , cord-028721-x6f26ahr 2304 29 suggesting suggest VBG cord-028721-x6f26ahr 2304 30 a a DT cord-028721-x6f26ahr 2304 31 meiotic meiotic JJ cord-028721-x6f26ahr 2304 32 anomaly anomaly NN cord-028721-x6f26ahr 2304 33 . . . cord-028721-x6f26ahr 2305 1 1003 1003 CD cord-028721-x6f26ahr 2305 2 , , , cord-028721-x6f26ahr 2306 1 1004 1004 CD cord-028721-x6f26ahr 2306 2 Irregularly irregularly RB cord-028721-x6f26ahr 2306 3 shaped shape VBN cord-028721-x6f26ahr 2306 4 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2306 5 are be VBP cord-028721-x6f26ahr 2306 6 characterized characterize VBN cord-028721-x6f26ahr 2306 7 by by IN cord-028721-x6f26ahr 2306 8 irregularity irregularity NN cord-028721-x6f26ahr 2306 9 in in IN cord-028721-x6f26ahr 2306 10 the the DT cord-028721-x6f26ahr 2306 11 shape shape NN cord-028721-x6f26ahr 2306 12 of of IN cord-028721-x6f26ahr 2306 13 the the DT cord-028721-x6f26ahr 2306 14 nucleus nucleus NN cord-028721-x6f26ahr 2306 15 or or CC cord-028721-x6f26ahr 2306 16 acrosome acrosome NN cord-028721-x6f26ahr 2306 17 . . . cord-028721-x6f26ahr 2307 1 1005 1005 CD cord-028721-x6f26ahr 2308 1 In in IN cord-028721-x6f26ahr 2308 2 the the DT cord-028721-x6f26ahr 2308 3 crater crater NN cord-028721-x6f26ahr 2308 4 defect defect NN cord-028721-x6f26ahr 2308 5 syndrome syndrome NN cord-028721-x6f26ahr 2308 6 , , , cord-028721-x6f26ahr 2308 7 there there EX cord-028721-x6f26ahr 2308 8 is be VBZ cord-028721-x6f26ahr 2308 9 invagination invagination NN cord-028721-x6f26ahr 2308 10 of of IN cord-028721-x6f26ahr 2308 11 the the DT cord-028721-x6f26ahr 2308 12 nuclear nuclear JJ cord-028721-x6f26ahr 2308 13 envelope envelope NN cord-028721-x6f26ahr 2308 14 in in IN cord-028721-x6f26ahr 2308 15 which which WDT cord-028721-x6f26ahr 2308 16 the the DT cord-028721-x6f26ahr 2308 17 acrosome acrosome NN cord-028721-x6f26ahr 2308 18 penetrates penetrate VBZ cord-028721-x6f26ahr 2308 19 . . . cord-028721-x6f26ahr 2309 1 The the DT cord-028721-x6f26ahr 2309 2 tail tail NN cord-028721-x6f26ahr 2309 3 is be VBZ cord-028721-x6f26ahr 2309 4 morphologically morphologically RB cord-028721-x6f26ahr 2309 5 normal normal JJ cord-028721-x6f26ahr 2309 6 , , , cord-028721-x6f26ahr 2309 7 and and CC cord-028721-x6f26ahr 2309 8 motility motility NN cord-028721-x6f26ahr 2309 9 is be VBZ cord-028721-x6f26ahr 2309 10 only only RB cord-028721-x6f26ahr 2309 11 slightly slightly RB cord-028721-x6f26ahr 2309 12 reduced reduce VBN cord-028721-x6f26ahr 2309 13 . . . cord-028721-x6f26ahr 2310 1 In in IN cord-028721-x6f26ahr 2310 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2310 3 with with IN cord-028721-x6f26ahr 2310 4 spoon spoon NN cord-028721-x6f26ahr 2310 5 - - HYPH cord-028721-x6f26ahr 2310 6 shaped shape VBN cord-028721-x6f26ahr 2310 7 nuclei nucleus NNS cord-028721-x6f26ahr 2310 8 , , , cord-028721-x6f26ahr 2310 9 the the DT cord-028721-x6f26ahr 2310 10 defect defect NN cord-028721-x6f26ahr 2310 11 is be VBZ cord-028721-x6f26ahr 2310 12 probably probably RB cord-028721-x6f26ahr 2310 13 genetic genetic JJ cord-028721-x6f26ahr 2310 14 . . . cord-028721-x6f26ahr 2311 1 Other other JJ cord-028721-x6f26ahr 2311 2 anomalies anomaly NNS cord-028721-x6f26ahr 2311 3 include include VBP cord-028721-x6f26ahr 2311 4 double double JJ cord-028721-x6f26ahr 2311 5 - - HYPH cord-028721-x6f26ahr 2311 6 headed headed JJ cord-028721-x6f26ahr 2311 7 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2311 8 with with IN cord-028721-x6f26ahr 2311 9 two two CD cord-028721-x6f26ahr 2311 10 nuclei nucleus NNS cord-028721-x6f26ahr 2311 11 sharing share VBG cord-028721-x6f26ahr 2311 12 a a DT cord-028721-x6f26ahr 2311 13 single single JJ cord-028721-x6f26ahr 2311 14 acrosome acrosome NN cord-028721-x6f26ahr 2311 15 . . . cord-028721-x6f26ahr 2312 1 1006 1006 CD cord-028721-x6f26ahr 2312 2 Anomalies Anomalies NNPS cord-028721-x6f26ahr 2312 3 in in IN cord-028721-x6f26ahr 2312 4 the the DT cord-028721-x6f26ahr 2312 5 spermatozoal spermatozoal NN cord-028721-x6f26ahr 2312 6 tail tail NN cord-028721-x6f26ahr 2312 7 Spermatozoal Spermatozoal NNP cord-028721-x6f26ahr 2312 8 tail tail NN cord-028721-x6f26ahr 2312 9 anomalies anomaly NNS cord-028721-x6f26ahr 2312 10 are be VBP cord-028721-x6f26ahr 2312 11 classifi classifi NNS cord-028721-x6f26ahr 2312 12 ed ed NN cord-028721-x6f26ahr 2312 13 as as IN cord-028721-x6f26ahr 2312 14 generalized generalized JJ cord-028721-x6f26ahr 2312 15 anomalies anomaly NNS cord-028721-x6f26ahr 2312 16 of of IN cord-028721-x6f26ahr 2312 17 the the DT cord-028721-x6f26ahr 2312 18 tail tail NN cord-028721-x6f26ahr 2312 19 or or CC cord-028721-x6f26ahr 2312 20 anomalies anomaly NNS cord-028721-x6f26ahr 2312 21 in in IN cord-028721-x6f26ahr 2312 22 defi defi NNP cord-028721-x6f26ahr 2312 23 ned ned NNP cord-028721-x6f26ahr 2312 24 tail tail NN cord-028721-x6f26ahr 2312 25 components component NNS cord-028721-x6f26ahr 2312 26 , , , cord-028721-x6f26ahr 2312 27 such such JJ cord-028721-x6f26ahr 2312 28 as as IN cord-028721-x6f26ahr 2312 29 the the DT cord-028721-x6f26ahr 2312 30 connecting connect VBG cord-028721-x6f26ahr 2312 31 piece piece NN cord-028721-x6f26ahr 2312 32 , , , cord-028721-x6f26ahr 2312 33 the the DT cord-028721-x6f26ahr 2312 34 axoneme axoneme NN cord-028721-x6f26ahr 2312 35 , , , cord-028721-x6f26ahr 2312 36 or or CC cord-028721-x6f26ahr 2312 37 the the DT cord-028721-x6f26ahr 2312 38 periaxonemal periaxonemal JJ cord-028721-x6f26ahr 2312 39 structure structure NN cord-028721-x6f26ahr 2312 40 . . . cord-028721-x6f26ahr 2313 1 1007 1007 CD cord-028721-x6f26ahr 2313 2 Generalized generalized JJ cord-028721-x6f26ahr 2313 3 anomalies anomaly NNS cord-028721-x6f26ahr 2313 4 in in IN cord-028721-x6f26ahr 2313 5 the the DT cord-028721-x6f26ahr 2313 6 tail tail NN cord-028721-x6f26ahr 2313 7 Cytoplasmic Cytoplasmic NNP cord-028721-x6f26ahr 2313 8 remnants remnant NNS cord-028721-x6f26ahr 2313 9 . . . cord-028721-x6f26ahr 2314 1 The the DT cord-028721-x6f26ahr 2314 2 presence presence NN cord-028721-x6f26ahr 2314 3 of of IN cord-028721-x6f26ahr 2314 4 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2314 5 droplets droplet NNS cord-028721-x6f26ahr 2314 6 is be VBZ cord-028721-x6f26ahr 2314 7 normal normal JJ cord-028721-x6f26ahr 2314 8 during during IN cord-028721-x6f26ahr 2314 9 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 2314 10 . . . cord-028721-x6f26ahr 2315 1 An an DT cord-028721-x6f26ahr 2315 2 elevated elevated JJ cord-028721-x6f26ahr 2315 3 number number NN cord-028721-x6f26ahr 2315 4 of of IN cord-028721-x6f26ahr 2315 5 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2315 6 with with IN cord-028721-x6f26ahr 2315 7 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2315 8 droplets droplet NNS cord-028721-x6f26ahr 2315 9 in in IN cord-028721-x6f26ahr 2315 10 semen semen NN cord-028721-x6f26ahr 2315 11 is be VBZ cord-028721-x6f26ahr 2315 12 associated associate VBN cord-028721-x6f26ahr 2315 13 with with IN cord-028721-x6f26ahr 2315 14 premature premature JJ cord-028721-x6f26ahr 2315 15 sloughing sloughing NN cord-028721-x6f26ahr 2315 16 of of IN cord-028721-x6f26ahr 2315 17 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2315 18 , , , cord-028721-x6f26ahr 2315 19 as as IN cord-028721-x6f26ahr 2315 20 occurs occur VBZ cord-028721-x6f26ahr 2315 21 in in IN cord-028721-x6f26ahr 2315 22 varicocele varicocele NN cord-028721-x6f26ahr 2315 23 , , , cord-028721-x6f26ahr 2315 24 and and CC cord-028721-x6f26ahr 2315 25 should should MD cord-028721-x6f26ahr 2315 26 not not RB cord-028721-x6f26ahr 2315 27 be be VB cord-028721-x6f26ahr 2315 28 misinterpreted misinterpret VBN cord-028721-x6f26ahr 2315 29 as as IN cord-028721-x6f26ahr 2315 30 spermatozoa spermatozoa VBN cord-028721-x6f26ahr 2315 31 with with IN cord-028721-x6f26ahr 2315 32 excess excess JJ cord-028721-x6f26ahr 2315 33 residual residual JJ cord-028721-x6f26ahr 2315 34 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2315 35 . . . cord-028721-x6f26ahr 2316 1 1008 1008 CD cord-028721-x6f26ahr 2317 1 These these DT cord-028721-x6f26ahr 2317 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2317 3 are be VBP cord-028721-x6f26ahr 2317 4 very very RB cord-028721-x6f26ahr 2317 5 often often RB cord-028721-x6f26ahr 2317 6 abnormal abnormal JJ cord-028721-x6f26ahr 2317 7 and and CC cord-028721-x6f26ahr 2317 8 the the DT cord-028721-x6f26ahr 2317 9 residual residual JJ cord-028721-x6f26ahr 2317 10 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2317 11 may may MD cord-028721-x6f26ahr 2317 12 be be VB cord-028721-x6f26ahr 2317 13 located locate VBN cord-028721-x6f26ahr 2317 14 around around IN cord-028721-x6f26ahr 2317 15 the the DT cord-028721-x6f26ahr 2317 16 intermediate intermediate JJ cord-028721-x6f26ahr 2317 17 piece piece NN cord-028721-x6f26ahr 2317 18 or or CC cord-028721-x6f26ahr 2317 19 surrounding surround VBG cord-028721-x6f26ahr 2317 20 the the DT cord-028721-x6f26ahr 2317 21 head head NN cord-028721-x6f26ahr 2317 22 . . . cord-028721-x6f26ahr 2318 1 These these DT cord-028721-x6f26ahr 2318 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2318 3 also also RB cord-028721-x6f26ahr 2318 4 have have VBP cord-028721-x6f26ahr 2318 5 other other JJ cord-028721-x6f26ahr 2318 6 fl fl NNP cord-028721-x6f26ahr 2318 7 agellar agellar JJ cord-028721-x6f26ahr 2318 8 anomalies anomaly NNS cord-028721-x6f26ahr 2318 9 . . . cord-028721-x6f26ahr 2319 1 Bent bent JJ cord-028721-x6f26ahr 2319 2 tail tail NN cord-028721-x6f26ahr 2319 3 . . . cord-028721-x6f26ahr 2320 1 A a DT cord-028721-x6f26ahr 2320 2 bend bend NN cord-028721-x6f26ahr 2320 3 in in IN cord-028721-x6f26ahr 2320 4 the the DT cord-028721-x6f26ahr 2320 5 tail tail NN cord-028721-x6f26ahr 2320 6 may may MD cord-028721-x6f26ahr 2320 7 occur occur VB cord-028721-x6f26ahr 2320 8 at at IN cord-028721-x6f26ahr 2320 9 the the DT cord-028721-x6f26ahr 2320 10 level level NN cord-028721-x6f26ahr 2320 11 of of IN cord-028721-x6f26ahr 2320 12 the the DT cord-028721-x6f26ahr 2320 13 connecting connect VBG cord-028721-x6f26ahr 2320 14 piece piece NN cord-028721-x6f26ahr 2320 15 or or CC cord-028721-x6f26ahr 2320 16 the the DT cord-028721-x6f26ahr 2320 17 intermediate intermediate JJ cord-028721-x6f26ahr 2320 18 piece piece NN cord-028721-x6f26ahr 2320 19 . . . cord-028721-x6f26ahr 2321 1 In in IN cord-028721-x6f26ahr 2321 2 bends bend NNS cord-028721-x6f26ahr 2321 3 of of IN cord-028721-x6f26ahr 2321 4 the the DT cord-028721-x6f26ahr 2321 5 connecting connect VBG cord-028721-x6f26ahr 2321 6 piece piece NN cord-028721-x6f26ahr 2321 7 , , , cord-028721-x6f26ahr 2321 8 the the DT cord-028721-x6f26ahr 2321 9 tail tail NN cord-028721-x6f26ahr 2321 10 is be VBZ cord-028721-x6f26ahr 2321 11 laterally laterally RB cord-028721-x6f26ahr 2321 12 implanted implant VBN cord-028721-x6f26ahr 2321 13 and and CC cord-028721-x6f26ahr 2321 14 forms form VBZ cord-028721-x6f26ahr 2321 15 an an DT cord-028721-x6f26ahr 2321 16 angle angle NN cord-028721-x6f26ahr 2321 17 with with IN cord-028721-x6f26ahr 2321 18 a a DT cord-028721-x6f26ahr 2321 19 nucleus nucleus NN cord-028721-x6f26ahr 2321 20 that that WDT cord-028721-x6f26ahr 2321 21 displays display VBZ cord-028721-x6f26ahr 2321 22 a a DT cord-028721-x6f26ahr 2321 23 thin thin JJ cord-028721-x6f26ahr 2321 24 base base NN cord-028721-x6f26ahr 2321 25 . . . cord-028721-x6f26ahr 2322 1 Bends bend NNS cord-028721-x6f26ahr 2322 2 of of IN cord-028721-x6f26ahr 2322 3 the the DT cord-028721-x6f26ahr 2322 4 intermediate intermediate JJ cord-028721-x6f26ahr 2322 5 piece piece NN cord-028721-x6f26ahr 2322 6 are be VBP cord-028721-x6f26ahr 2322 7 associated associate VBN cord-028721-x6f26ahr 2322 8 with with IN cord-028721-x6f26ahr 2322 9 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2322 10 droplets droplet NNS cord-028721-x6f26ahr 2322 11 , , , cord-028721-x6f26ahr 2322 12 malposition malposition NN cord-028721-x6f26ahr 2322 13 of of IN cord-028721-x6f26ahr 2322 14 mitochondria mitochondrion NNS cord-028721-x6f26ahr 2322 15 , , , cord-028721-x6f26ahr 2322 16 and and CC cord-028721-x6f26ahr 2322 17 loss loss NN cord-028721-x6f26ahr 2322 18 of of IN cord-028721-x6f26ahr 2322 19 the the DT cord-028721-x6f26ahr 2322 20 parallel parallel JJ cord-028721-x6f26ahr 2322 21 arrangement arrangement NN cord-028721-x6f26ahr 2322 22 of of IN cord-028721-x6f26ahr 2322 23 the the DT cord-028721-x6f26ahr 2322 24 dense dense JJ cord-028721-x6f26ahr 2322 25 outer outer JJ cord-028721-x6f26ahr 2322 26 fi fi NN cord-028721-x6f26ahr 2322 27 bers ber NNS cord-028721-x6f26ahr 2322 28 . . . cord-028721-x6f26ahr 2323 1 Coiled coiled JJ cord-028721-x6f26ahr 2323 2 tail tail NN cord-028721-x6f26ahr 2323 3 . . . cord-028721-x6f26ahr 2324 1 Spermatozoa Spermatozoa VBN cord-028721-x6f26ahr 2324 2 with with IN cord-028721-x6f26ahr 2324 3 a a DT cord-028721-x6f26ahr 2324 4 coiled coiled JJ cord-028721-x6f26ahr 2324 5 tail tail NN cord-028721-x6f26ahr 2324 6 are be VBP cord-028721-x6f26ahr 2324 7 a a DT cord-028721-x6f26ahr 2324 8 frequent frequent JJ cord-028721-x6f26ahr 2324 9 fi fi NN cord-028721-x6f26ahr 2324 10 nding nding NN cord-028721-x6f26ahr 2324 11 in in IN cord-028721-x6f26ahr 2324 12 centrifuged centrifuge VBN cord-028721-x6f26ahr 2324 13 semen semen NN cord-028721-x6f26ahr 2324 14 , , , cord-028721-x6f26ahr 2324 15 but but CC cord-028721-x6f26ahr 2324 16 they -PRON- PRP cord-028721-x6f26ahr 2324 17 may may MD cord-028721-x6f26ahr 2324 18 also also RB cord-028721-x6f26ahr 2324 19 be be VB cord-028721-x6f26ahr 2324 20 a a DT cord-028721-x6f26ahr 2324 21 true true JJ cord-028721-x6f26ahr 2324 22 abnormality abnormality NN cord-028721-x6f26ahr 2324 23 . . . cord-028721-x6f26ahr 2325 1 These these DT cord-028721-x6f26ahr 2325 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2325 3 have have VBP cord-028721-x6f26ahr 2325 4 a a DT cord-028721-x6f26ahr 2325 5 perinuclear perinuclear JJ cord-028721-x6f26ahr 2325 6 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2325 7 remnant remnant NN cord-028721-x6f26ahr 2325 8 containing contain VBG cord-028721-x6f26ahr 2325 9 a a DT cord-028721-x6f26ahr 2325 10 fl fl NNP cord-028721-x6f26ahr 2325 11 agellum agellum NN cord-028721-x6f26ahr 2325 12 that that WDT cord-028721-x6f26ahr 2325 13 is be VBZ cord-028721-x6f26ahr 2325 14 coiled coil VBN cord-028721-x6f26ahr 2325 15 around around IN cord-028721-x6f26ahr 2325 16 the the DT cord-028721-x6f26ahr 2325 17 nucleus nucleus NN cord-028721-x6f26ahr 2325 18 and and CC cord-028721-x6f26ahr 2325 19 along along IN cord-028721-x6f26ahr 2325 20 the the DT cord-028721-x6f26ahr 2325 21 middle middle JJ cord-028721-x6f26ahr 2325 22 or or CC cord-028721-x6f26ahr 2325 23 principal principal JJ cord-028721-x6f26ahr 2325 24 pieces piece NNS cord-028721-x6f26ahr 2326 1 ( ( -LRB- cord-028721-x6f26ahr 2326 2 Fig Fig NNP cord-028721-x6f26ahr 2326 3 . . . cord-028721-x6f26ahr 2326 4 _SP cord-028721-x6f26ahr 2326 5 12 12 CD cord-028721-x6f26ahr 2326 6 - - SYM cord-028721-x6f26ahr 2326 7 115 115 CD cord-028721-x6f26ahr 2326 8 ) ) -RRB- cord-028721-x6f26ahr 2326 9 . . . cord-028721-x6f26ahr 2327 1 This this DT cord-028721-x6f26ahr 2327 2 is be VBZ cord-028721-x6f26ahr 2327 3 frequently frequently RB cord-028721-x6f26ahr 2327 4 associated associate VBN cord-028721-x6f26ahr 2327 5 with with IN cord-028721-x6f26ahr 2327 6 abnormalities abnormality NNS cord-028721-x6f26ahr 2327 7 of of IN cord-028721-x6f26ahr 2327 8 the the DT cord-028721-x6f26ahr 2327 9 periaxonemal periaxonemal JJ cord-028721-x6f26ahr 2327 10 structures structure NNS cord-028721-x6f26ahr 2327 11 . . . cord-028721-x6f26ahr 2328 1 Tail tail NN cord-028721-x6f26ahr 2328 2 stump stump NN cord-028721-x6f26ahr 2328 3 ( ( -LRB- cord-028721-x6f26ahr 2328 4 short short JJ cord-028721-x6f26ahr 2328 5 - - HYPH cord-028721-x6f26ahr 2328 6 tail tail NN cord-028721-x6f26ahr 2328 7 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2328 8 ) ) -RRB- cord-028721-x6f26ahr 2328 9 . . . cord-028721-x6f26ahr 2329 1 The the DT cord-028721-x6f26ahr 2329 2 presence presence NN cord-028721-x6f26ahr 2329 3 of of IN cord-028721-x6f26ahr 2329 4 many many JJ cord-028721-x6f26ahr 2329 5 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2329 6 with with IN cord-028721-x6f26ahr 2329 7 short short JJ cord-028721-x6f26ahr 2329 8 , , , cord-028721-x6f26ahr 2329 9 thick thick JJ cord-028721-x6f26ahr 2329 10 tails tail NNS cord-028721-x6f26ahr 2329 11 in in IN cord-028721-x6f26ahr 2329 12 semen semen NN cord-028721-x6f26ahr 2329 13 represents represent VBZ cord-028721-x6f26ahr 2329 14 a a DT cord-028721-x6f26ahr 2329 15 well well JJ cord-028721-x6f26ahr 2329 16 - - HYPH cord-028721-x6f26ahr 2329 17 defi defi NN cord-028721-x6f26ahr 2329 18 ned ned NNP cord-028721-x6f26ahr 2329 19 teratozoospermic teratozoospermic NNP cord-028721-x6f26ahr 2329 20 syndrome syndrome NNP cord-028721-x6f26ahr 2329 21 . . . cord-028721-x6f26ahr 2330 1 1009 1009 CD cord-028721-x6f26ahr 2331 1 Ultrastructural ultrastructural JJ cord-028721-x6f26ahr 2331 2 examination examination NN cord-028721-x6f26ahr 2331 3 reveals reveal VBZ cord-028721-x6f26ahr 2331 4 hypertrophy hypertrophy NN cord-028721-x6f26ahr 2331 5 and and CC cord-028721-x6f26ahr 2331 6 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2331 7 of of IN cord-028721-x6f26ahr 2331 8 the the DT cord-028721-x6f26ahr 2331 9 fi fi NNP cord-028721-x6f26ahr 2331 10 brous brous JJ cord-028721-x6f26ahr 2331 11 sheath sheath NN cord-028721-x6f26ahr 2331 12 , , , cord-028721-x6f26ahr 2331 13 1010 1010 CD cord-028721-x6f26ahr 2331 14 hence hence RB cord-028721-x6f26ahr 2331 15 this this DT cord-028721-x6f26ahr 2331 16 syndrome syndrome NN cord-028721-x6f26ahr 2331 17 has have VBZ cord-028721-x6f26ahr 2331 18 also also RB cord-028721-x6f26ahr 2331 19 been be VBN cord-028721-x6f26ahr 2331 20 termed term VBN cord-028721-x6f26ahr 2331 21 ' ' `` cord-028721-x6f26ahr 2331 22 fi fi NN cord-028721-x6f26ahr 2331 23 brous brous JJ cord-028721-x6f26ahr 2331 24 sheath sheath NN cord-028721-x6f26ahr 2331 25 dysplasia dysplasia NN cord-028721-x6f26ahr 2331 26 . . . cord-028721-x6f26ahr 2331 27 ' ' '' cord-028721-x6f26ahr 2332 1 1011 1011 CD cord-028721-x6f26ahr 2332 2 Additional additional JJ cord-028721-x6f26ahr 2332 3 axonemal axonemal JJ cord-028721-x6f26ahr 2332 4 malformations malformation NNS cord-028721-x6f26ahr 2332 5 , , , cord-028721-x6f26ahr 2332 6 including include VBG cord-028721-x6f26ahr 2332 7 absence absence NN cord-028721-x6f26ahr 2332 8 of of IN cord-028721-x6f26ahr 2332 9 the the DT cord-028721-x6f26ahr 2332 10 central central JJ cord-028721-x6f26ahr 2332 11 pair pair NN cord-028721-x6f26ahr 2332 12 of of IN cord-028721-x6f26ahr 2332 13 microtu microtu NNP cord-028721-x6f26ahr 2332 14 - - HYPH cord-028721-x6f26ahr 2332 15 bules bules NNP cord-028721-x6f26ahr 2332 16 ( ( -LRB- cord-028721-x6f26ahr 2332 17 Fig Fig NNP cord-028721-x6f26ahr 2332 18 . . . cord-028721-x6f26ahr 2332 19 12 12 CD cord-028721-x6f26ahr 2332 20 - - SYM cord-028721-x6f26ahr 2332 21 116 116 CD cord-028721-x6f26ahr 2332 22 ) ) -RRB- cord-028721-x6f26ahr 2332 23 1012 1012 CD cord-028721-x6f26ahr 2332 24 and and CC cord-028721-x6f26ahr 2332 25 , , , cord-028721-x6f26ahr 2332 26 less less RBR cord-028721-x6f26ahr 2332 27 frequently frequently RB cord-028721-x6f26ahr 2332 28 , , , cord-028721-x6f26ahr 2332 29 lack lack NN cord-028721-x6f26ahr 2332 30 of of IN cord-028721-x6f26ahr 2332 31 dynein dynein JJ cord-028721-x6f26ahr 2332 32 arms arm NNS cord-028721-x6f26ahr 2332 33 , , , cord-028721-x6f26ahr 2332 34 are be VBP cord-028721-x6f26ahr 2332 35 observed observe VBN cord-028721-x6f26ahr 2332 36 in in IN cord-028721-x6f26ahr 2332 37 50 50 CD cord-028721-x6f26ahr 2332 38 % % NN cord-028721-x6f26ahr 2332 39 of of IN cord-028721-x6f26ahr 2332 40 cases case NNS cord-028721-x6f26ahr 2332 41 . . . cord-028721-x6f26ahr 2333 1 About about RB cord-028721-x6f26ahr 2333 2 24 24 CD cord-028721-x6f26ahr 2333 3 % % NN cord-028721-x6f26ahr 2333 4 of of IN cord-028721-x6f26ahr 2333 5 patients patient NNS cord-028721-x6f26ahr 2333 6 have have VBP cord-028721-x6f26ahr 2333 7 respiratory respiratory JJ cord-028721-x6f26ahr 2333 8 disease disease NN cord-028721-x6f26ahr 2333 9 , , , cord-028721-x6f26ahr 2333 10 such such JJ cord-028721-x6f26ahr 2333 11 as as IN cord-028721-x6f26ahr 2333 12 rhinosinusitis rhinosinusitis NNP cord-028721-x6f26ahr 2333 13 , , , cord-028721-x6f26ahr 2333 14 bronchitis bronchitis NN cord-028721-x6f26ahr 2333 15 , , , cord-028721-x6f26ahr 2333 16 and and CC cord-028721-x6f26ahr 2333 17 bronchiectasis bronchiectasis NN cord-028721-x6f26ahr 2333 18 from from IN cord-028721-x6f26ahr 2333 19 an an DT cord-028721-x6f26ahr 2333 20 early early JJ cord-028721-x6f26ahr 2333 21 age age NN cord-028721-x6f26ahr 2333 22 . . . cord-028721-x6f26ahr 2334 1 Similar similar JJ cord-028721-x6f26ahr 2334 2 fi fi IN cord-028721-x6f26ahr 2334 3 ndings nding NNS cord-028721-x6f26ahr 2334 4 have have VBP cord-028721-x6f26ahr 2334 5 been be VBN cord-028721-x6f26ahr 2334 6 reported report VBN cord-028721-x6f26ahr 2334 7 in in IN cord-028721-x6f26ahr 2334 8 the the DT cord-028721-x6f26ahr 2334 9 cilia cilia NN cord-028721-x6f26ahr 2334 10 of of IN cord-028721-x6f26ahr 2334 11 the the DT cord-028721-x6f26ahr 2334 12 upper upper JJ cord-028721-x6f26ahr 2334 13 respiratory respiratory JJ cord-028721-x6f26ahr 2334 14 tract tract NN cord-028721-x6f26ahr 2334 15 , , , cord-028721-x6f26ahr 2334 16 and and CC cord-028721-x6f26ahr 2334 17 thus thus RB cord-028721-x6f26ahr 2334 18 a a DT cord-028721-x6f26ahr 2334 19 relationship relationship NN cord-028721-x6f26ahr 2334 20 between between IN cord-028721-x6f26ahr 2334 21 fi fi NNP cord-028721-x6f26ahr 2334 22 brous brous JJ cord-028721-x6f26ahr 2334 23 sheath sheath NN cord-028721-x6f26ahr 2334 24 dysplasia dysplasia NNP cord-028721-x6f26ahr 2334 25 and and CC cord-028721-x6f26ahr 2334 26 immotile immotile NNP cord-028721-x6f26ahr 2334 27 cilia cilia NNP cord-028721-x6f26ahr 2334 28 syndrome syndrome NN cord-028721-x6f26ahr 2334 29 has have VBZ cord-028721-x6f26ahr 2334 30 been be VBN cord-028721-x6f26ahr 2334 31 assumed assume VBN cord-028721-x6f26ahr 2334 32 . . . cord-028721-x6f26ahr 2335 1 Clinical clinical JJ cord-028721-x6f26ahr 2335 2 presentation presentation NN cord-028721-x6f26ahr 2335 3 may may MD cord-028721-x6f26ahr 2335 4 be be VB cord-028721-x6f26ahr 2335 5 sporadic sporadic JJ cord-028721-x6f26ahr 2335 6 or or CC cord-028721-x6f26ahr 2335 7 familial familial JJ cord-028721-x6f26ahr 2335 8 . . . cord-028721-x6f26ahr 2336 1 The the DT cord-028721-x6f26ahr 2336 2 cause cause NN cord-028721-x6f26ahr 2336 3 of of IN cord-028721-x6f26ahr 2336 4 fi fi NN cord-028721-x6f26ahr 2336 5 brous brous JJ cord-028721-x6f26ahr 2336 6 sheath sheath NN cord-028721-x6f26ahr 2336 7 dysplasia dysplasia NN cord-028721-x6f26ahr 2336 8 and and CC cord-028721-x6f26ahr 2336 9 the the DT cord-028721-x6f26ahr 2336 10 subsequent subsequent JJ cord-028721-x6f26ahr 2336 11 lack lack NN cord-028721-x6f26ahr 2336 12 of of IN cord-028721-x6f26ahr 2336 13 motility motility NN cord-028721-x6f26ahr 2336 14 in in IN cord-028721-x6f26ahr 2336 15 these these DT cord-028721-x6f26ahr 2336 16 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2336 17 is be VBZ cord-028721-x6f26ahr 2336 18 probably probably RB cord-028721-x6f26ahr 2336 19 related relate VBN cord-028721-x6f26ahr 2336 20 to to IN cord-028721-x6f26ahr 2336 21 the the DT cord-028721-x6f26ahr 2336 22 occurrence occurrence NN cord-028721-x6f26ahr 2336 23 of of IN cord-028721-x6f26ahr 2336 24 deletions deletion NNS cord-028721-x6f26ahr 2336 25 in in IN cord-028721-x6f26ahr 2336 26 Akap3 Akap3 NNS cord-028721-x6f26ahr 2336 27 and and CC cord-028721-x6f26ahr 2336 28 Akap4 akap4 JJ cord-028721-x6f26ahr 2336 29 genes gene NNS cord-028721-x6f26ahr 2336 30 , , , cord-028721-x6f26ahr 2336 31 as as RB cord-028721-x6f26ahr 2336 32 well well RB cord-028721-x6f26ahr 2336 33 as as IN cord-028721-x6f26ahr 2336 34 the the DT cord-028721-x6f26ahr 2336 35 absence absence NN cord-028721-x6f26ahr 2336 36 of of IN cord-028721-x6f26ahr 2336 37 Akp4 Akp4 NNP cord-028721-x6f26ahr 2336 38 protein protein NN cord-028721-x6f26ahr 2336 39 in in IN cord-028721-x6f26ahr 2336 40 the the DT cord-028721-x6f26ahr 2336 41 fi fi NNP cord-028721-x6f26ahr 2336 42 brous brous JJ cord-028721-x6f26ahr 2336 43 sheath sheath NN cord-028721-x6f26ahr 2336 44 . . . cord-028721-x6f26ahr 2337 1 1013 1013 CD cord-028721-x6f26ahr 2337 2 Multiple multiple JJ cord-028721-x6f26ahr 2337 3 tails tail NNS cord-028721-x6f26ahr 2337 4 . . . cord-028721-x6f26ahr 2338 1 The the DT cord-028721-x6f26ahr 2338 2 presence presence NN cord-028721-x6f26ahr 2338 3 of of IN cord-028721-x6f26ahr 2338 4 more more JJR cord-028721-x6f26ahr 2338 5 than than IN cord-028721-x6f26ahr 2338 6 two two CD cord-028721-x6f26ahr 2338 7 tails tail NNS cord-028721-x6f26ahr 2338 8 is be VBZ cord-028721-x6f26ahr 2338 9 associated associate VBN cord-028721-x6f26ahr 2338 10 with with IN cord-028721-x6f26ahr 2338 11 macrocephalic macrocephalic NNP cord-028721-x6f26ahr 2338 12 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2338 13 . . . cord-028721-x6f26ahr 2339 1 1014 1014 CD cord-028721-x6f26ahr 2339 2 Sperm Sperm NNP cord-028721-x6f26ahr 2339 3 tail tail NN cord-028721-x6f26ahr 2339 4 agenesis agenesis NN cord-028721-x6f26ahr 2339 5 . . . cord-028721-x6f26ahr 2340 1 Teratozoospermia teratozoospermia NN cord-028721-x6f26ahr 2340 2 with with IN cord-028721-x6f26ahr 2340 3 100 100 CD cord-028721-x6f26ahr 2340 4 % % NN cord-028721-x6f26ahr 2340 5 sperm sperm NN cord-028721-x6f26ahr 2340 6 tail tail NN cord-028721-x6f26ahr 2340 7 agenesis agenesis NN cord-028721-x6f26ahr 2340 8 has have VBZ cord-028721-x6f26ahr 2340 9 been be VBN cord-028721-x6f26ahr 2340 10 reported report VBN cord-028721-x6f26ahr 2340 11 in in IN cord-028721-x6f26ahr 2340 12 patients patient NNS cord-028721-x6f26ahr 2340 13 with with IN cord-028721-x6f26ahr 2340 14 a a DT cord-028721-x6f26ahr 2340 15 high high JJ cord-028721-x6f26ahr 2340 16 degree degree NN cord-028721-x6f26ahr 2340 17 of of IN cord-028721-x6f26ahr 2340 18 consanguinity consanguinity NN cord-028721-x6f26ahr 2340 19 . . . cord-028721-x6f26ahr 2341 1 These these DT cord-028721-x6f26ahr 2341 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2341 3 also also RB cord-028721-x6f26ahr 2341 4 have have VBP cord-028721-x6f26ahr 2341 5 defects defect NNS cord-028721-x6f26ahr 2341 6 in in IN cord-028721-x6f26ahr 2341 7 chromatin chromatin NN cord-028721-x6f26ahr 2341 8 condensation condensation NN cord-028721-x6f26ahr 2341 9 and and CC cord-028721-x6f26ahr 2341 10 residual residual JJ cord-028721-x6f26ahr 2341 11 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2341 12 droplets droplet NNS cord-028721-x6f26ahr 2341 13 . . . cord-028721-x6f26ahr 2342 1 1015 1015 CD cord-028721-x6f26ahr 2342 2 Anomalies anomaly NNS cord-028721-x6f26ahr 2342 3 of of IN cord-028721-x6f26ahr 2342 4 the the DT cord-028721-x6f26ahr 2342 5 connecting connect VBG cord-028721-x6f26ahr 2342 6 piece piece NN cord-028721-x6f26ahr 2342 7 Anomalies anomaly NNS cord-028721-x6f26ahr 2342 8 of of IN cord-028721-x6f26ahr 2342 9 the the DT cord-028721-x6f26ahr 2342 10 connecting connect VBG cord-028721-x6f26ahr 2342 11 piece piece NN cord-028721-x6f26ahr 2342 12 are be VBP cord-028721-x6f26ahr 2342 13 classifi classifi NNP cord-028721-x6f26ahr 2342 14 ed ed NNP cord-028721-x6f26ahr 2342 15 as as IN cord-028721-x6f26ahr 2342 16 acephalic acephalic NNP cord-028721-x6f26ahr 2342 17 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2342 18 , , , cord-028721-x6f26ahr 2342 19 defi defi NNP cord-028721-x6f26ahr 2342 20 cient cient NNP cord-028721-x6f26ahr 2342 21 organization organization NNP cord-028721-x6f26ahr 2342 22 of of IN cord-028721-x6f26ahr 2342 23 the the DT cord-028721-x6f26ahr 2342 24 connecting connect VBG cord-028721-x6f26ahr 2342 25 piece piece NN cord-028721-x6f26ahr 2342 26 , , , cord-028721-x6f26ahr 2342 27 and and CC cord-028721-x6f26ahr 2342 28 separation separation NN cord-028721-x6f26ahr 2342 29 between between IN cord-028721-x6f26ahr 2342 30 the the DT cord-028721-x6f26ahr 2342 31 head head NN cord-028721-x6f26ahr 2342 32 and and CC cord-028721-x6f26ahr 2342 33 the the DT cord-028721-x6f26ahr 2342 34 tail tail NN cord-028721-x6f26ahr 2342 35 . . . cord-028721-x6f26ahr 2343 1 Acephalic Acephalic NNP cord-028721-x6f26ahr 2343 2 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2343 3 are be VBP cord-028721-x6f26ahr 2343 4 known know VBN cord-028721-x6f26ahr 2343 5 as as IN cord-028721-x6f26ahr 2343 6 ' ' `` cord-028721-x6f26ahr 2343 7 pin pin NN cord-028721-x6f26ahr 2343 8 - - HYPH cord-028721-x6f26ahr 2343 9 headed headed JJ cord-028721-x6f26ahr 2343 10 , , , cord-028721-x6f26ahr 2343 11 ' ' '' cord-028721-x6f26ahr 2343 12 although although IN cord-028721-x6f26ahr 2343 13 they -PRON- PRP cord-028721-x6f26ahr 2343 14 lack lack VBP cord-028721-x6f26ahr 2343 15 a a DT cord-028721-x6f26ahr 2343 16 true true JJ cord-028721-x6f26ahr 2343 17 head head NN cord-028721-x6f26ahr 2343 18 ; ; : cord-028721-x6f26ahr 2343 19 the the DT cord-028721-x6f26ahr 2343 20 small small JJ cord-028721-x6f26ahr 2343 21 cephalic cephalic JJ cord-028721-x6f26ahr 2343 22 knob knob NN cord-028721-x6f26ahr 2343 23 - - HYPH cord-028721-x6f26ahr 2343 24 like like JJ cord-028721-x6f26ahr 2343 25 thickening thickening NN cord-028721-x6f26ahr 2343 26 is be VBZ cord-028721-x6f26ahr 2343 27 actually actually RB cord-028721-x6f26ahr 2343 28 a a DT cord-028721-x6f26ahr 2343 29 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 2343 30 droplet droplet NN cord-028721-x6f26ahr 2343 31 with with IN cord-028721-x6f26ahr 2343 32 a a DT cord-028721-x6f26ahr 2343 33 variable variable JJ cord-028721-x6f26ahr 2343 34 degree degree NN cord-028721-x6f26ahr 2343 35 of of IN cord-028721-x6f26ahr 2343 36 mitochondrial mitochondrial JJ cord-028721-x6f26ahr 2343 37 organization organization NN cord-028721-x6f26ahr 2343 38 giving give VBG cord-028721-x6f26ahr 2343 39 rise rise NN cord-028721-x6f26ahr 2343 40 to to IN cord-028721-x6f26ahr 2343 41 a a DT cord-028721-x6f26ahr 2343 42 variable variable JJ cord-028721-x6f26ahr 2343 43 degree degree NN cord-028721-x6f26ahr 2343 44 of of IN cord-028721-x6f26ahr 2343 45 motility motility NN cord-028721-x6f26ahr 2343 46 . . . cord-028721-x6f26ahr 2344 1 1016 1016 CD cord-028721-x6f26ahr 2345 1 This this DT cord-028721-x6f26ahr 2345 2 anomaly anomaly NN cord-028721-x6f26ahr 2345 3 is be VBZ cord-028721-x6f26ahr 2345 4 due due JJ cord-028721-x6f26ahr 2345 5 to to IN cord-028721-x6f26ahr 2345 6 an an DT cord-028721-x6f26ahr 2345 7 early early JJ cord-028721-x6f26ahr 2345 8 failure failure NN cord-028721-x6f26ahr 2345 9 in in IN cord-028721-x6f26ahr 2345 10 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 2345 11 . . . cord-028721-x6f26ahr 2346 1 It -PRON- PRP cord-028721-x6f26ahr 2346 2 may may MD cord-028721-x6f26ahr 2346 3 be be VB cord-028721-x6f26ahr 2346 4 familial familial JJ cord-028721-x6f26ahr 2346 5 in in IN cord-028721-x6f26ahr 2346 6 some some DT cord-028721-x6f26ahr 2346 7 cases case NNS cord-028721-x6f26ahr 2346 8 . . . cord-028721-x6f26ahr 2347 1 1017 1017 CD cord-028721-x6f26ahr 2347 2 , , , cord-028721-x6f26ahr 2347 3 1018 1018 CD cord-028721-x6f26ahr 2347 4 Spermatozoa Spermatozoa NNP cord-028721-x6f26ahr 2347 5 with with IN cord-028721-x6f26ahr 2347 6 defi defi NNP cord-028721-x6f26ahr 2347 7 cient cient NNP cord-028721-x6f26ahr 2347 8 organization organization NNP cord-028721-x6f26ahr 2347 9 of of IN cord-028721-x6f26ahr 2347 10 the the DT cord-028721-x6f26ahr 2347 11 connecting connect VBG cord-028721-x6f26ahr 2347 12 piece piece NN cord-028721-x6f26ahr 2347 13 have have VBP cord-028721-x6f26ahr 2347 14 narrowing narrow VBG cord-028721-x6f26ahr 2347 15 at at IN cord-028721-x6f26ahr 2347 16 this this DT cord-028721-x6f26ahr 2347 17 level level NN cord-028721-x6f26ahr 2347 18 , , , cord-028721-x6f26ahr 2347 19 with with IN cord-028721-x6f26ahr 2347 20 loss loss NN cord-028721-x6f26ahr 2347 21 of of IN cord-028721-x6f26ahr 2347 22 alignment alignment NN cord-028721-x6f26ahr 2347 23 of of IN cord-028721-x6f26ahr 2347 24 the the DT cord-028721-x6f26ahr 2347 25 head head NN cord-028721-x6f26ahr 2347 26 and and CC cord-028721-x6f26ahr 2347 27 fl fl NNP cord-028721-x6f26ahr 2347 28 agellum agellum NNP cord-028721-x6f26ahr 2347 29 axes axes NNP cord-028721-x6f26ahr 2347 30 . . . cord-028721-x6f26ahr 2348 1 Spermatozoa Spermatozoa VBN cord-028721-x6f26ahr 2348 2 with with IN cord-028721-x6f26ahr 2348 3 a a DT cord-028721-x6f26ahr 2348 4 separated separated JJ cord-028721-x6f26ahr 2348 5 head head NN cord-028721-x6f26ahr 2348 6 and and CC cord-028721-x6f26ahr 2348 7 fl fl NNP cord-028721-x6f26ahr 2348 8 agellum agellum NN cord-028721-x6f26ahr 2348 9 , , , cord-028721-x6f26ahr 2348 10 known know VBN cord-028721-x6f26ahr 2348 11 as as IN cord-028721-x6f26ahr 2348 12 decapitated decapitate VBN cord-028721-x6f26ahr 2348 13 and and CC cord-028721-x6f26ahr 2348 14 decaudated decaudated JJ cord-028721-x6f26ahr 2348 15 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2348 16 , , , cord-028721-x6f26ahr 2348 17 are be VBP cord-028721-x6f26ahr 2348 18 also also RB cord-028721-x6f26ahr 2348 19 the the DT cord-028721-x6f26ahr 2348 20 result result NN cord-028721-x6f26ahr 2348 21 of of IN cord-028721-x6f26ahr 2348 22 an an DT cord-028721-x6f26ahr 2348 23 anomaly anomaly NN cord-028721-x6f26ahr 2348 24 in in IN cord-028721-x6f26ahr 2348 25 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 2348 26 , , , cord-028721-x6f26ahr 2348 27 but but CC cord-028721-x6f26ahr 2348 28 the the DT cord-028721-x6f26ahr 2348 29 separation separation NN cord-028721-x6f26ahr 2348 30 between between IN cord-028721-x6f26ahr 2348 31 heads head NNS cord-028721-x6f26ahr 2348 32 and and CC cord-028721-x6f26ahr 2348 33 tails tail NNS cord-028721-x6f26ahr 2348 34 can can MD cord-028721-x6f26ahr 2348 35 occur occur VB cord-028721-x6f26ahr 2348 36 during during IN cord-028721-x6f26ahr 2348 37 spermiation spermiation NN cord-028721-x6f26ahr 2348 38 or or CC cord-028721-x6f26ahr 2348 39 at at IN cord-028721-x6f26ahr 2348 40 any any DT cord-028721-x6f26ahr 2348 41 level level NN cord-028721-x6f26ahr 2348 42 of of IN cord-028721-x6f26ahr 2348 43 the the DT cord-028721-x6f26ahr 2348 44 sperm sperm NN cord-028721-x6f26ahr 2348 45 excretory excretory JJ cord-028721-x6f26ahr 2348 46 ducts duct NNS cord-028721-x6f26ahr 2348 47 . . . cord-028721-x6f26ahr 2349 1 1019 1019 CD cord-028721-x6f26ahr 2349 2 , , , cord-028721-x6f26ahr 2349 3 1020 1020 CD cord-028721-x6f26ahr 2349 4 Anomalies Anomalies NNPS cord-028721-x6f26ahr 2349 5 in in IN cord-028721-x6f26ahr 2349 6 axoneme axoneme NNP cord-028721-x6f26ahr 2349 7 Abnormalities Abnormalities NNPS cord-028721-x6f26ahr 2349 8 of of IN cord-028721-x6f26ahr 2349 9 the the DT cord-028721-x6f26ahr 2349 10 axoneme axoneme NNP cord-028721-x6f26ahr 2349 11 are be VBP cord-028721-x6f26ahr 2349 12 classifi classifi NNP cord-028721-x6f26ahr 2349 13 ed ed NNP cord-028721-x6f26ahr 2349 14 as as IN cord-028721-x6f26ahr 2349 15 numerical numerical JJ cord-028721-x6f26ahr 2349 16 anomalies anomaly NNS cord-028721-x6f26ahr 2349 17 , , , cord-028721-x6f26ahr 2349 18 microtubular microtubular NNP cord-028721-x6f26ahr 2349 19 ectopia ectopia NNP cord-028721-x6f26ahr 2349 20 , , , cord-028721-x6f26ahr 2349 21 and and CC cord-028721-x6f26ahr 2349 22 immotile immotile NNP cord-028721-x6f26ahr 2349 23 cilia cilia NNP cord-028721-x6f26ahr 2349 24 syndrome syndrome NN cord-028721-x6f26ahr 2349 25 . . . cord-028721-x6f26ahr 2350 1 The the DT cord-028721-x6f26ahr 2350 2 most most RBS cord-028721-x6f26ahr 2350 3 common common JJ cord-028721-x6f26ahr 2350 4 numerical numerical JJ cord-028721-x6f26ahr 2350 5 anomalies anomaly NNS cord-028721-x6f26ahr 2350 6 are be VBP cord-028721-x6f26ahr 2350 7 the the DT cord-028721-x6f26ahr 2350 8 absence absence NN cord-028721-x6f26ahr 2350 9 of of IN cord-028721-x6f26ahr 2350 10 one one CD cord-028721-x6f26ahr 2350 11 or or CC cord-028721-x6f26ahr 2350 12 both both DT cord-028721-x6f26ahr 2350 13 microtubules microtubule NNS cord-028721-x6f26ahr 2350 14 of of IN cord-028721-x6f26ahr 2350 15 the the DT cord-028721-x6f26ahr 2350 16 central central JJ cord-028721-x6f26ahr 2350 17 pair pair NN cord-028721-x6f26ahr 2350 18 and and CC cord-028721-x6f26ahr 2350 19 complete complete JJ cord-028721-x6f26ahr 2350 20 lack lack NN cord-028721-x6f26ahr 2350 21 of of IN cord-028721-x6f26ahr 2350 22 the the DT cord-028721-x6f26ahr 2350 23 axoneme axoneme NN cord-028721-x6f26ahr 2350 24 . . . cord-028721-x6f26ahr 2351 1 Spermatozoa Spermatozoa NNP cord-028721-x6f26ahr 2351 2 lacking lack VBG cord-028721-x6f26ahr 2351 3 the the DT cord-028721-x6f26ahr 2351 4 central central JJ cord-028721-x6f26ahr 2351 5 microtubule microtubule JJ cord-028721-x6f26ahr 2351 6 pair pair NN cord-028721-x6f26ahr 2351 7 also also RB cord-028721-x6f26ahr 2351 8 lack lack VBP cord-028721-x6f26ahr 2351 9 the the DT cord-028721-x6f26ahr 2351 10 central central JJ cord-028721-x6f26ahr 2351 11 sheath sheath NN cord-028721-x6f26ahr 2351 12 and and CC cord-028721-x6f26ahr 2351 13 are be VBP cord-028721-x6f26ahr 2351 14 immotile immotile NNP cord-028721-x6f26ahr 2351 15 , , , cord-028721-x6f26ahr 2351 16 although although IN cord-028721-x6f26ahr 2351 17 they -PRON- PRP cord-028721-x6f26ahr 2351 18 are be VBP cord-028721-x6f26ahr 2351 19 normal normal JJ cord-028721-x6f26ahr 2351 20 by by IN cord-028721-x6f26ahr 2351 21 light light JJ cord-028721-x6f26ahr 2351 22 microscopy microscopy NNS cord-028721-x6f26ahr 2351 23 . . . cord-028721-x6f26ahr 2352 1 Familial familial JJ cord-028721-x6f26ahr 2352 2 cases case NNS cord-028721-x6f26ahr 2352 3 have have VBP cord-028721-x6f26ahr 2352 4 been be VBN cord-028721-x6f26ahr 2352 5 reported report VBN cord-028721-x6f26ahr 2352 6 . . . cord-028721-x6f26ahr 2353 1 1021 1021 CD cord-028721-x6f26ahr 2354 1 This this DT cord-028721-x6f26ahr 2354 2 anomaly anomaly NN cord-028721-x6f26ahr 2354 3 may may MD cord-028721-x6f26ahr 2354 4 be be VB cord-028721-x6f26ahr 2354 5 associated associate VBN cord-028721-x6f26ahr 2354 6 with with IN cord-028721-x6f26ahr 2354 7 ciliary ciliary JJ cord-028721-x6f26ahr 2354 8 dyskinesia dyskinesia NN cord-028721-x6f26ahr 2354 9 . . . cord-028721-x6f26ahr 2355 1 1022 1022 CD cord-028721-x6f26ahr 2355 2 Immotile Immotile NNP cord-028721-x6f26ahr 2355 3 cilia cilia NN cord-028721-x6f26ahr 2355 4 syndrome syndrome NN cord-028721-x6f26ahr 2355 5 ( ( -LRB- cord-028721-x6f26ahr 2355 6 primary primary JJ cord-028721-x6f26ahr 2355 7 ciliary ciliary NN cord-028721-x6f26ahr 2355 8 dyskinesia dyskinesia NN cord-028721-x6f26ahr 2355 9 ) ) -RRB- cord-028721-x6f26ahr 2355 10 1023 1023 CD cord-028721-x6f26ahr 2355 11 refers refer VBZ cord-028721-x6f26ahr 2355 12 to to IN cord-028721-x6f26ahr 2355 13 patients patient NNS cord-028721-x6f26ahr 2355 14 having have VBG cord-028721-x6f26ahr 2355 15 low low JJ cord-028721-x6f26ahr 2355 16 mucociliary mucociliary JJ cord-028721-x6f26ahr 2355 17 clearance clearance NN cord-028721-x6f26ahr 2355 18 associated associate VBN cord-028721-x6f26ahr 2355 19 with with IN cord-028721-x6f26ahr 2355 20 otitis otitis NN cord-028721-x6f26ahr 2355 21 , , , cord-028721-x6f26ahr 2355 22 sinusitis sinusitis NN cord-028721-x6f26ahr 2355 23 , , , cord-028721-x6f26ahr 2355 24 bronchitis bronchitis NN cord-028721-x6f26ahr 2355 25 , , , cord-028721-x6f26ahr 2355 26 bronchiectasis bronchiectasis NN cord-028721-x6f26ahr 2355 27 , , , cord-028721-x6f26ahr 2355 28 and and CC cord-028721-x6f26ahr 2355 29 immotile immotile NNP cord-028721-x6f26ahr 2355 30 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2355 31 . . . cord-028721-x6f26ahr 2356 1 Most Most JJS cord-028721-x6f26ahr 2356 2 patients patient NNS cord-028721-x6f26ahr 2356 3 have have VBP cord-028721-x6f26ahr 2356 4 the the DT cord-028721-x6f26ahr 2356 5 same same JJ cord-028721-x6f26ahr 2356 6 defect defect NN cord-028721-x6f26ahr 2356 7 in in IN cord-028721-x6f26ahr 2356 8 the the DT cord-028721-x6f26ahr 2356 9 axoneme axoneme NN cord-028721-x6f26ahr 2356 10 and and CC cord-028721-x6f26ahr 2356 11 cilia cilium NNS cord-028721-x6f26ahr 2356 12 of of IN cord-028721-x6f26ahr 2356 13 the the DT cord-028721-x6f26ahr 2356 14 respiratory respiratory JJ cord-028721-x6f26ahr 2356 15 mucosa mucosa NN cord-028721-x6f26ahr 2356 16 . . . cord-028721-x6f26ahr 2357 1 The the DT cord-028721-x6f26ahr 2357 2 frequency frequency NN cord-028721-x6f26ahr 2357 3 of of IN cord-028721-x6f26ahr 2357 4 this this DT cord-028721-x6f26ahr 2357 5 syndrome syndrome NN cord-028721-x6f26ahr 2357 6 is be VBZ cord-028721-x6f26ahr 2357 7 estimated estimate VBN cord-028721-x6f26ahr 2357 8 at at IN cord-028721-x6f26ahr 2357 9 between between IN cord-028721-x6f26ahr 2357 10 1 1 CD cord-028721-x6f26ahr 2357 11 in in IN cord-028721-x6f26ahr 2357 12 20 20 CD cord-028721-x6f26ahr 2357 13 000 000 CD cord-028721-x6f26ahr 2357 14 and and CC cord-028721-x6f26ahr 2357 15 1 1 CD cord-028721-x6f26ahr 2357 16 in in IN cord-028721-x6f26ahr 2357 17 60 60 CD cord-028721-x6f26ahr 2357 18 000 000 CD cord-028721-x6f26ahr 2357 19 men man NNS cord-028721-x6f26ahr 2357 20 . . . cord-028721-x6f26ahr 2358 1 Clinical clinical JJ cord-028721-x6f26ahr 2358 2 symptoms symptom NNS cord-028721-x6f26ahr 2358 3 consist consist VBP cord-028721-x6f26ahr 2358 4 of of IN cord-028721-x6f26ahr 2358 5 reduced reduce VBN cord-028721-x6f26ahr 2358 6 clearance clearance NN cord-028721-x6f26ahr 2358 7 of of IN cord-028721-x6f26ahr 2358 8 ciliary ciliary JJ cord-028721-x6f26ahr 2358 9 mucus mucus NN cord-028721-x6f26ahr 2358 10 in in IN cord-028721-x6f26ahr 2358 11 the the DT cord-028721-x6f26ahr 2358 12 airway airway NN cord-028721-x6f26ahr 2358 13 , , , cord-028721-x6f26ahr 2358 14 with with IN cord-028721-x6f26ahr 2358 15 onset onset NN cord-028721-x6f26ahr 2358 16 at at IN cord-028721-x6f26ahr 2358 17 infancy infancy NN cord-028721-x6f26ahr 2358 18 . . . cord-028721-x6f26ahr 2359 1 In in IN cord-028721-x6f26ahr 2359 2 order order NN cord-028721-x6f26ahr 2359 3 to to TO cord-028721-x6f26ahr 2359 4 prevent prevent VB cord-028721-x6f26ahr 2359 5 the the DT cord-028721-x6f26ahr 2359 6 later later JJ cord-028721-x6f26ahr 2359 7 development development NN cord-028721-x6f26ahr 2359 8 of of IN cord-028721-x6f26ahr 2359 9 bronchiectasis bronchiectasis NN cord-028721-x6f26ahr 2359 10 , , , cord-028721-x6f26ahr 2359 11 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 2359 12 study study NN cord-028721-x6f26ahr 2359 13 of of IN cord-028721-x6f26ahr 2359 14 the the DT cord-028721-x6f26ahr 2359 15 respiratory respiratory JJ cord-028721-x6f26ahr 2359 16 mucosa mucosa NN cord-028721-x6f26ahr 2359 17 is be VBZ cord-028721-x6f26ahr 2359 18 advisable advisable JJ cord-028721-x6f26ahr 2359 19 if if IN cord-028721-x6f26ahr 2359 20 other other JJ cord-028721-x6f26ahr 2359 21 disorders disorder NNS cord-028721-x6f26ahr 2359 22 have have VBP cord-028721-x6f26ahr 2359 23 been be VBN cord-028721-x6f26ahr 2359 24 excluded exclude VBN cord-028721-x6f26ahr 2359 25 , , , cord-028721-x6f26ahr 2359 26 including include VBG cord-028721-x6f26ahr 2359 27 cystic cystic NN cord-028721-x6f26ahr 2359 28 fi fi NNP cord-028721-x6f26ahr 2359 29 brosis brosis NN cord-028721-x6f26ahr 2359 30 , , , cord-028721-x6f26ahr 2359 31 allergy allergy NN cord-028721-x6f26ahr 2359 32 and and CC cord-028721-x6f26ahr 2359 33 other other JJ cord-028721-x6f26ahr 2359 34 immune immune JJ cord-028721-x6f26ahr 2359 35 disorders disorder NNS cord-028721-x6f26ahr 2359 36 , , , cord-028721-x6f26ahr 2359 37 α α NN cord-028721-x6f26ahr 2359 38 1antitrypsin 1antitrypsin CD cord-028721-x6f26ahr 2359 39 defi defi NNP cord-028721-x6f26ahr 2359 40 ciency ciency NNP cord-028721-x6f26ahr 2359 41 , , , cord-028721-x6f26ahr 2359 42 and and CC cord-028721-x6f26ahr 2359 43 cardiovascular cardiovascular JJ cord-028721-x6f26ahr 2359 44 and and CC cord-028721-x6f26ahr 2359 45 metabolic metabolic JJ cord-028721-x6f26ahr 2359 46 diseases disease NNS cord-028721-x6f26ahr 2359 47 . . . cord-028721-x6f26ahr 2360 1 1024 1024 CD cord-028721-x6f26ahr 2361 1 The the DT cord-028721-x6f26ahr 2361 2 most most RBS cord-028721-x6f26ahr 2361 3 frequent frequent JJ cord-028721-x6f26ahr 2361 4 anomalies anomaly NNS cord-028721-x6f26ahr 2361 5 of of IN cord-028721-x6f26ahr 2361 6 this this DT cord-028721-x6f26ahr 2361 7 syndrome syndrome NN cord-028721-x6f26ahr 2361 8 are be VBP cord-028721-x6f26ahr 2361 9 the the DT cord-028721-x6f26ahr 2361 10 absence absence NN cord-028721-x6f26ahr 2361 11 of of IN cord-028721-x6f26ahr 2361 12 microtubule microtubule JJ cord-028721-x6f26ahr 2361 13 doublets doublet NNS cord-028721-x6f26ahr 2361 14 and and CC cord-028721-x6f26ahr 2361 15 peripheral peripheral JJ cord-028721-x6f26ahr 2361 16 junctions junction NNS cord-028721-x6f26ahr 2361 17 , , , cord-028721-x6f26ahr 2361 18 the the DT cord-028721-x6f26ahr 2361 19 central central JJ cord-028721-x6f26ahr 2361 20 microtubule microtubule JJ cord-028721-x6f26ahr 2361 21 pair pair NN cord-028721-x6f26ahr 2361 22 , , , cord-028721-x6f26ahr 2361 23 the the DT cord-028721-x6f26ahr 2361 24 outer outer JJ cord-028721-x6f26ahr 2361 25 dynein dynein JJ cord-028721-x6f26ahr 2361 26 arms arm NNS cord-028721-x6f26ahr 2361 27 , , , cord-028721-x6f26ahr 2361 28 the the DT cord-028721-x6f26ahr 2361 29 central central JJ cord-028721-x6f26ahr 2361 30 junctions junction NNS cord-028721-x6f26ahr 2361 31 , , , cord-028721-x6f26ahr 2361 32 the the DT cord-028721-x6f26ahr 2361 33 two two CD cord-028721-x6f26ahr 2361 34 dynein dynein JJ cord-028721-x6f26ahr 2361 35 arms arm NNS cord-028721-x6f26ahr 2361 36 , , , cord-028721-x6f26ahr 2361 37 and and CC cord-028721-x6f26ahr 2361 38 the the DT cord-028721-x6f26ahr 2361 39 inner inner JJ cord-028721-x6f26ahr 2361 40 dynein dynein JJ cord-028721-x6f26ahr 2361 41 arm arm NN cord-028721-x6f26ahr 2361 42 plus plus CC cord-028721-x6f26ahr 2361 43 the the DT cord-028721-x6f26ahr 2361 44 peripheral peripheral JJ cord-028721-x6f26ahr 2361 45 junctions junction NNS cord-028721-x6f26ahr 2362 1 ( ( -LRB- cord-028721-x6f26ahr 2362 2 Fig Fig NNP cord-028721-x6f26ahr 2362 3 . . . cord-028721-x6f26ahr 2362 4 12 12 CD cord-028721-x6f26ahr 2362 5 - - SYM cord-028721-x6f26ahr 2362 6 117 117 CD cord-028721-x6f26ahr 2362 7 ) ) -RRB- cord-028721-x6f26ahr 2362 8 . . . cord-028721-x6f26ahr 2363 1 Spermatozoa spermatozoa NN cord-028721-x6f26ahr 2363 2 lacking lack VBG cord-028721-x6f26ahr 2363 3 the the DT cord-028721-x6f26ahr 2363 4 two two CD cord-028721-x6f26ahr 2363 5 dynein dynein JJ cord-028721-x6f26ahr 2363 6 arms arm NNS cord-028721-x6f26ahr 2363 7 or or CC cord-028721-x6f26ahr 2363 8 the the DT cord-028721-x6f26ahr 2363 9 peripheral peripheral JJ cord-028721-x6f26ahr 2363 10 junctions junction NNS cord-028721-x6f26ahr 2363 11 are be VBP cord-028721-x6f26ahr 2363 12 immotile immotile NNP cord-028721-x6f26ahr 2363 13 . . . cord-028721-x6f26ahr 2364 1 Reduced reduced JJ cord-028721-x6f26ahr 2364 2 motility motility NN cord-028721-x6f26ahr 2364 3 is be VBZ cord-028721-x6f26ahr 2364 4 seen see VBN cord-028721-x6f26ahr 2364 5 in in IN cord-028721-x6f26ahr 2364 6 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2364 7 with with IN cord-028721-x6f26ahr 2364 8 only only RB cord-028721-x6f26ahr 2364 9 one one CD cord-028721-x6f26ahr 2364 10 dynein dynein JJ cord-028721-x6f26ahr 2364 11 arm arm NN cord-028721-x6f26ahr 2364 12 . . . cord-028721-x6f26ahr 2365 1 Kartagener Kartagener NNP cord-028721-x6f26ahr 2365 2 's 's POS cord-028721-x6f26ahr 2365 3 syndrome syndrome NN cord-028721-x6f26ahr 2365 4 is be VBZ cord-028721-x6f26ahr 2365 5 a a DT cord-028721-x6f26ahr 2365 6 variant variant NN cord-028721-x6f26ahr 2365 7 of of IN cord-028721-x6f26ahr 2365 8 the the DT cord-028721-x6f26ahr 2365 9 immotile immotile NNP cord-028721-x6f26ahr 2365 10 cilia cilia NNP cord-028721-x6f26ahr 2365 11 syndrome syndrome NN cord-028721-x6f26ahr 2365 12 characterized characterize VBN cord-028721-x6f26ahr 2365 13 by by IN cord-028721-x6f26ahr 2365 14 the the DT cord-028721-x6f26ahr 2365 15 classic classic NNP cord-028721-x6f26ahr 2365 16 triad triad NNP cord-028721-x6f26ahr 2365 17 of of IN cord-028721-x6f26ahr 2365 18 situs situs NN cord-028721-x6f26ahr 2365 19 inversus inversus NN cord-028721-x6f26ahr 2365 20 , , , cord-028721-x6f26ahr 2365 21 bronchiectasis bronchiectasis NN cord-028721-x6f26ahr 2365 22 , , , cord-028721-x6f26ahr 2365 23 and and CC cord-028721-x6f26ahr 2365 24 chronic chronic JJ cord-028721-x6f26ahr 2365 25 sinusitis sinusitis NN cord-028721-x6f26ahr 2365 26 . . . cord-028721-x6f26ahr 2366 1 The the DT cord-028721-x6f26ahr 2366 2 syndrome syndrome NN cord-028721-x6f26ahr 2366 3 has have VBZ cord-028721-x6f26ahr 2366 4 autosomal autosomal JJ cord-028721-x6f26ahr 2366 5 recessive recessive JJ cord-028721-x6f26ahr 2366 6 inheritance inheritance NN cord-028721-x6f26ahr 2366 7 1025 1025 CD cord-028721-x6f26ahr 2366 8 and and CC cord-028721-x6f26ahr 2366 9 is be VBZ cord-028721-x6f26ahr 2366 10 found find VBN cord-028721-x6f26ahr 2366 11 in in IN cord-028721-x6f26ahr 2366 12 20 20 CD cord-028721-x6f26ahr 2366 13 - - SYM cord-028721-x6f26ahr 2366 14 25 25 CD cord-028721-x6f26ahr 2366 15 % % NN cord-028721-x6f26ahr 2366 16 of of IN cord-028721-x6f26ahr 2366 17 patients patient NNS cord-028721-x6f26ahr 2366 18 with with IN cord-028721-x6f26ahr 2366 19 situs situs NN cord-028721-x6f26ahr 2366 20 inversus inversus NN cord-028721-x6f26ahr 2366 21 . . . cord-028721-x6f26ahr 2367 1 1026 1026 CD cord-028721-x6f26ahr 2367 2 Anomalies anomaly NNS cord-028721-x6f26ahr 2367 3 in in IN cord-028721-x6f26ahr 2367 4 periaxonemal periaxonemal JJ cord-028721-x6f26ahr 2367 5 structures structure NNS cord-028721-x6f26ahr 2367 6 Periaxonemal Periaxonemal NNP cord-028721-x6f26ahr 2367 7 abnormalities abnormality NNS cord-028721-x6f26ahr 2367 8 include include VBP cord-028721-x6f26ahr 2367 9 mitochondrial mitochondrial JJ cord-028721-x6f26ahr 2367 10 sheath sheath NN cord-028721-x6f26ahr 2367 11 defects defect NNS cord-028721-x6f26ahr 2367 12 , , , cord-028721-x6f26ahr 2367 13 1027 1027 CD cord-028721-x6f26ahr 2367 14 malposition malposition NN cord-028721-x6f26ahr 2367 15 of of IN cord-028721-x6f26ahr 2367 16 the the DT cord-028721-x6f26ahr 2367 17 annulus annulus NN cord-028721-x6f26ahr 2367 18 , , , cord-028721-x6f26ahr 2367 19 alteration alteration NN cord-028721-x6f26ahr 2367 20 in in IN cord-028721-x6f26ahr 2367 21 number number NN cord-028721-x6f26ahr 2367 22 , , , cord-028721-x6f26ahr 2367 23 shape shape NN cord-028721-x6f26ahr 2367 24 , , , cord-028721-x6f26ahr 2367 25 or or CC cord-028721-x6f26ahr 2367 26 length length NN cord-028721-x6f26ahr 2367 27 of of IN cord-028721-x6f26ahr 2367 28 the the DT cord-028721-x6f26ahr 2367 29 outer outer JJ cord-028721-x6f26ahr 2367 30 dense dense JJ cord-028721-x6f26ahr 2367 31 fi fi NN cord-028721-x6f26ahr 2367 32 bers ber NNS cord-028721-x6f26ahr 2367 33 , , , cord-028721-x6f26ahr 2367 34 and and CC cord-028721-x6f26ahr 2367 35 absence absence NN cord-028721-x6f26ahr 2367 36 , , , cord-028721-x6f26ahr 2367 37 thickening thickening NN cord-028721-x6f26ahr 2367 38 , , , cord-028721-x6f26ahr 2367 39 or or CC cord-028721-x6f26ahr 2367 40 disruption disruption NN cord-028721-x6f26ahr 2367 41 of of IN cord-028721-x6f26ahr 2367 42 the the DT cord-028721-x6f26ahr 2367 43 fi fi NNP cord-028721-x6f26ahr 2367 44 brous brous JJ cord-028721-x6f26ahr 2367 45 sheath sheath NN cord-028721-x6f26ahr 2367 46 . . . cord-028721-x6f26ahr 2368 1 1011 1011 CD cord-028721-x6f26ahr 2368 2 , , , cord-028721-x6f26ahr 2368 3 1028 1028 CD cord-028721-x6f26ahr 2368 4 Many many JJ cord-028721-x6f26ahr 2368 5 cases case NNS cord-028721-x6f26ahr 2368 6 of of IN cord-028721-x6f26ahr 2368 7 asthenozoospermia asthenozoospermia NN cord-028721-x6f26ahr 2368 8 , , , cord-028721-x6f26ahr 2368 9 present present JJ cord-028721-x6f26ahr 2368 10 in in IN cord-028721-x6f26ahr 2368 11 30 30 CD cord-028721-x6f26ahr 2368 12 % % NN cord-028721-x6f26ahr 2368 13 of of IN cord-028721-x6f26ahr 2368 14 infertile infertile JJ cord-028721-x6f26ahr 2368 15 men man NNS cord-028721-x6f26ahr 2368 16 , , , cord-028721-x6f26ahr 2368 17 may may MD cord-028721-x6f26ahr 2368 18 be be VB cord-028721-x6f26ahr 2368 19 attributable attributable JJ cord-028721-x6f26ahr 2368 20 to to IN cord-028721-x6f26ahr 2368 21 defi defi NNP cord-028721-x6f26ahr 2368 22 cient cient NNP cord-028721-x6f26ahr 2368 23 mitochondrial mitochondrial NN cord-028721-x6f26ahr 2368 24 function function NN cord-028721-x6f26ahr 2368 25 , , , cord-028721-x6f26ahr 2368 26 possibly possibly RB cord-028721-x6f26ahr 2368 27 caused cause VBN cord-028721-x6f26ahr 2368 28 by by IN cord-028721-x6f26ahr 2368 29 mutations mutation NNS cord-028721-x6f26ahr 2368 30 in in IN cord-028721-x6f26ahr 2368 31 their -PRON- PRP$ cord-028721-x6f26ahr 2368 32 DNA dna NN cord-028721-x6f26ahr 2368 33 . . . cord-028721-x6f26ahr 2369 1 1029 1029 CD cord-028721-x6f26ahr 2369 2 Abnormalities abnormality NNS cord-028721-x6f26ahr 2369 3 of of IN cord-028721-x6f26ahr 2369 4 the the DT cord-028721-x6f26ahr 2369 5 dense dense JJ cord-028721-x6f26ahr 2369 6 fi fi NN cord-028721-x6f26ahr 2369 7 bers ber NNS cord-028721-x6f26ahr 2369 8 are be VBP cord-028721-x6f26ahr 2369 9 associated associate VBN cord-028721-x6f26ahr 2369 10 with with IN cord-028721-x6f26ahr 2369 11 deficient deficient JJ cord-028721-x6f26ahr 2369 12 motility motility NN cord-028721-x6f26ahr 2369 13 . . . cord-028721-x6f26ahr 2370 1 Abnormalities abnormality NNS cord-028721-x6f26ahr 2370 2 of of IN cord-028721-x6f26ahr 2370 3 the the DT cord-028721-x6f26ahr 2370 4 fi fi NNP cord-028721-x6f26ahr 2370 5 brous brous JJ cord-028721-x6f26ahr 2370 6 sheath sheath NN cord-028721-x6f26ahr 2370 7 include include VBP cord-028721-x6f26ahr 2370 8 , , , cord-028721-x6f26ahr 2370 9 in in IN cord-028721-x6f26ahr 2370 10 addition addition NN cord-028721-x6f26ahr 2370 11 to to IN cord-028721-x6f26ahr 2370 12 the the DT cord-028721-x6f26ahr 2370 13 abovementioned abovementioned JJ cord-028721-x6f26ahr 2370 14 dysplasia dysplasia NN cord-028721-x6f26ahr 2370 15 of of IN cord-028721-x6f26ahr 2370 16 the the DT cord-028721-x6f26ahr 2370 17 fi fi NNP cord-028721-x6f26ahr 2370 18 brous brous JJ cord-028721-x6f26ahr 2370 19 sheath sheath NN cord-028721-x6f26ahr 2370 20 , , , cord-028721-x6f26ahr 2370 21 absence absence NN cord-028721-x6f26ahr 2370 22 of of IN cord-028721-x6f26ahr 2370 23 the the DT cord-028721-x6f26ahr 2370 24 fi fi NNP cord-028721-x6f26ahr 2370 25 brous brous JJ cord-028721-x6f26ahr 2370 26 sheath sheath NN cord-028721-x6f26ahr 2370 27 , , , cord-028721-x6f26ahr 2370 28 and and CC cord-028721-x6f26ahr 2370 29 redundant redundant JJ cord-028721-x6f26ahr 2370 30 fi fi NN cord-028721-x6f26ahr 2370 31 brous brous JJ cord-028721-x6f26ahr 2370 32 sheath sheath NN cord-028721-x6f26ahr 2370 33 material material NN cord-028721-x6f26ahr 2370 34 associated associate VBN cord-028721-x6f26ahr 2370 35 with with IN cord-028721-x6f26ahr 2370 36 a a DT cord-028721-x6f26ahr 2370 37 defi defi NNP cord-028721-x6f26ahr 2370 38 cit cit NN cord-028721-x6f26ahr 2370 39 or or CC cord-028721-x6f26ahr 2370 40 lack lack NN cord-028721-x6f26ahr 2370 41 of of IN cord-028721-x6f26ahr 2370 42 mitochondria mitochondrion NNS cord-028721-x6f26ahr 2370 43 . . . cord-028721-x6f26ahr 2371 1 1030 1030 CD cord-028721-x6f26ahr 2372 1 The the DT cord-028721-x6f26ahr 2372 2 three three CD cord-028721-x6f26ahr 2372 3 defects defect NNS cord-028721-x6f26ahr 2372 4 are be VBP cord-028721-x6f26ahr 2372 5 probably probably RB cord-028721-x6f26ahr 2372 6 inherited inherit VBN cord-028721-x6f26ahr 2372 7 . . . cord-028721-x6f26ahr 2373 1 The the DT cord-028721-x6f26ahr 2373 2 incidence incidence NN cord-028721-x6f26ahr 2373 3 of of IN cord-028721-x6f26ahr 2373 4 intratubular intratubular JJ cord-028721-x6f26ahr 2373 5 germ germ NN cord-028721-x6f26ahr 2373 6 cell cell NN cord-028721-x6f26ahr 2373 7 neoplasia neoplasia NN cord-028721-x6f26ahr 2373 8 ( ( -LRB- cord-028721-x6f26ahr 2373 9 IGCN IGCN NNP cord-028721-x6f26ahr 2373 10 ) ) -RRB- cord-028721-x6f26ahr 2373 11 in in IN cord-028721-x6f26ahr 2373 12 infertile infertile JJ cord-028721-x6f26ahr 2373 13 patient patient NN cord-028721-x6f26ahr 2373 14 is be VBZ cord-028721-x6f26ahr 2373 15 0.4 0.4 CD cord-028721-x6f26ahr 2373 16 % % NN cord-028721-x6f26ahr 2373 17 in in IN cord-028721-x6f26ahr 2373 18 England England NNP cord-028721-x6f26ahr 2373 19 , , , cord-028721-x6f26ahr 2373 20 1031 1031 CD cord-028721-x6f26ahr 2373 21 0.7 0.7 CD cord-028721-x6f26ahr 2373 22 % % NN cord-028721-x6f26ahr 2373 23 in in IN cord-028721-x6f26ahr 2373 24 Spain Spain NNP cord-028721-x6f26ahr 2373 25 , , , cord-028721-x6f26ahr 2373 26 1932 1932 CD cord-028721-x6f26ahr 2373 27 0.73 0.73 CD cord-028721-x6f26ahr 2373 28 % % NN cord-028721-x6f26ahr 2373 29 in in IN cord-028721-x6f26ahr 2373 30 Germany Germany NNP cord-028721-x6f26ahr 2373 31 , , , cord-028721-x6f26ahr 2373 32 1033 1033 CD cord-028721-x6f26ahr 2373 33 and and CC cord-028721-x6f26ahr 2373 34 1.1 1.1 CD cord-028721-x6f26ahr 2373 35 % % NN cord-028721-x6f26ahr 2373 36 in in IN cord-028721-x6f26ahr 2373 37 Denmark Denmark NNP cord-028721-x6f26ahr 2373 38 . . . cord-028721-x6f26ahr 2374 1 1034 1034 CD cord-028721-x6f26ahr 2375 1 A a DT cord-028721-x6f26ahr 2375 2 higher high JJR cord-028721-x6f26ahr 2375 3 risk risk NN cord-028721-x6f26ahr 2375 4 occurs occur VBZ cord-028721-x6f26ahr 2375 5 in in IN cord-028721-x6f26ahr 2375 6 patients patient NNS cord-028721-x6f26ahr 2375 7 with with IN cord-028721-x6f26ahr 2375 8 severe severe JJ cord-028721-x6f26ahr 2375 9 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2375 10 ( ( -LRB- cord-028721-x6f26ahr 2375 11 fewer few JJR cord-028721-x6f26ahr 2375 12 than than IN cord-028721-x6f26ahr 2375 13 10 10 CD cord-028721-x6f26ahr 2375 14 million million CD cord-028721-x6f26ahr 2375 15 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2375 16 per per IN cord-028721-x6f26ahr 2375 17 milliliter milliliter NN cord-028721-x6f26ahr 2375 18 ) ) -RRB- cord-028721-x6f26ahr 2375 19 , , , cord-028721-x6f26ahr 2375 20 azoospermia azoospermia NN cord-028721-x6f26ahr 2375 21 associated associate VBN cord-028721-x6f26ahr 2375 22 with with IN cord-028721-x6f26ahr 2375 23 unilaterally unilaterally RB cord-028721-x6f26ahr 2375 24 or or CC cord-028721-x6f26ahr 2375 25 bilaterally bilaterally RB cord-028721-x6f26ahr 2375 26 diminished diminish VBN cord-028721-x6f26ahr 2375 27 testicular testicular JJ cord-028721-x6f26ahr 2375 28 volume volume NN cord-028721-x6f26ahr 2375 29 , , , cord-028721-x6f26ahr 2375 30 1035 1035 CD cord-028721-x6f26ahr 2375 31 a a DT cord-028721-x6f26ahr 2375 32 history history NN cord-028721-x6f26ahr 2375 33 of of IN cord-028721-x6f26ahr 2375 34 testicular testicular JJ cord-028721-x6f26ahr 2375 35 maldescent maldescent NN cord-028721-x6f26ahr 2375 36 , , , cord-028721-x6f26ahr 2375 37 1036 1036 CD cord-028721-x6f26ahr 2375 38 , , , cord-028721-x6f26ahr 2375 39 1037 1037 CD cord-028721-x6f26ahr 2375 40 or or CC cord-028721-x6f26ahr 2375 41 unilateral unilateral JJ cord-028721-x6f26ahr 2375 42 testicular testicular JJ cord-028721-x6f26ahr 2375 43 cancer cancer NN cord-028721-x6f26ahr 2375 44 . . . cord-028721-x6f26ahr 2376 1 1038 1038 CD cord-028721-x6f26ahr 2377 1 The the DT cord-028721-x6f26ahr 2377 2 cells cell NNS cord-028721-x6f26ahr 2377 3 of of IN cord-028721-x6f26ahr 2377 4 IGCN IGCN NNS cord-028721-x6f26ahr 2377 5 are be VBP cord-028721-x6f26ahr 2377 6 located locate VBN cord-028721-x6f26ahr 2377 7 in in IN cord-028721-x6f26ahr 2377 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 2377 9 tubules tubule NNS cord-028721-x6f26ahr 2377 10 with with IN cord-028721-x6f26ahr 2377 11 decreased decrease VBN cord-028721-x6f26ahr 2377 12 tubular tubular JJ cord-028721-x6f26ahr 2377 13 diameter diameter NN cord-028721-x6f26ahr 2377 14 and and CC cord-028721-x6f26ahr 2377 15 lacking lack VBG cord-028721-x6f26ahr 2377 16 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2377 17 . . . cord-028721-x6f26ahr 2378 1 These these DT cord-028721-x6f26ahr 2378 2 cells cell NNS cord-028721-x6f26ahr 2378 3 are be VBP cord-028721-x6f26ahr 2378 4 large large JJ cord-028721-x6f26ahr 2378 5 and and CC cord-028721-x6f26ahr 2378 6 have have VBP cord-028721-x6f26ahr 2378 7 pale pale JJ cord-028721-x6f26ahr 2378 8 cytoplasm cytoplasm NN cord-028721-x6f26ahr 2378 9 and and CC cord-028721-x6f26ahr 2378 10 large large JJ cord-028721-x6f26ahr 2378 11 and and CC cord-028721-x6f26ahr 2378 12 irregularly irregularly RB cord-028721-x6f26ahr 2378 13 outlined outline VBN cord-028721-x6f26ahr 2378 14 nuclei nucleus NNS cord-028721-x6f26ahr 2378 15 , , , cord-028721-x6f26ahr 2378 16 with with IN cord-028721-x6f26ahr 2378 17 one one CD cord-028721-x6f26ahr 2378 18 or or CC cord-028721-x6f26ahr 2378 19 several several JJ cord-028721-x6f26ahr 2378 20 prominent prominent JJ cord-028721-x6f26ahr 2378 21 nucleoli nucleolus NNS cord-028721-x6f26ahr 2378 22 . . . cord-028721-x6f26ahr 2379 1 They -PRON- PRP cord-028721-x6f26ahr 2379 2 stain stain VBP cord-028721-x6f26ahr 2379 3 intensely intensely RB cord-028721-x6f26ahr 2379 4 with with IN cord-028721-x6f26ahr 2379 5 periodic periodic JJ cord-028721-x6f26ahr 2379 6 acid acid NN cord-028721-x6f26ahr 2379 7 - - HYPH cord-028721-x6f26ahr 2379 8 Schiff Schiff NNP cord-028721-x6f26ahr 2379 9 and and CC cord-028721-x6f26ahr 2379 10 express express JJ cord-028721-x6f26ahr 2379 11 placenta placenta NN cord-028721-x6f26ahr 2379 12 - - HYPH cord-028721-x6f26ahr 2379 13 like like JJ cord-028721-x6f26ahr 2379 14 alkaline alkaline JJ cord-028721-x6f26ahr 2379 15 phosphatase phosphatase NN cord-028721-x6f26ahr 2379 16 , , , cord-028721-x6f26ahr 2379 17 c c NN cord-028721-x6f26ahr 2379 18 - - HYPH cord-028721-x6f26ahr 2379 19 kit kit NN cord-028721-x6f26ahr 2379 20 , , , cord-028721-x6f26ahr 2379 21 and and CC cord-028721-x6f26ahr 2379 22 the the DT cord-028721-x6f26ahr 2379 23 cell cell NN cord-028721-x6f26ahr 2379 24 adhesion adhesion NN cord-028721-x6f26ahr 2379 25 molecule molecule NN cord-028721-x6f26ahr 2379 26 CD44 CD44 NNP cord-028721-x6f26ahr 2379 27 . . . cord-028721-x6f26ahr 2380 1 1039 1039 CD cord-028721-x6f26ahr 2381 1 A a DT cord-028721-x6f26ahr 2381 2 reduction reduction NN cord-028721-x6f26ahr 2381 3 in in IN cord-028721-x6f26ahr 2381 4 the the DT cord-028721-x6f26ahr 2381 5 number number NN cord-028721-x6f26ahr 2381 6 or or CC cord-028721-x6f26ahr 2381 7 absence absence NN cord-028721-x6f26ahr 2381 8 of of IN cord-028721-x6f26ahr 2381 9 Leydig Leydig NNP cord-028721-x6f26ahr 2381 10 cells cell NNS cord-028721-x6f26ahr 2381 11 is be VBZ cord-028721-x6f26ahr 2381 12 infrequent infrequent JJ cord-028721-x6f26ahr 2381 13 in in IN cord-028721-x6f26ahr 2381 14 infertility infertility NN cord-028721-x6f26ahr 2381 15 , , , cord-028721-x6f26ahr 2381 16 and and CC cord-028721-x6f26ahr 2381 17 only only RB cord-028721-x6f26ahr 2381 18 occurs occur VBZ cord-028721-x6f26ahr 2381 19 in in IN cord-028721-x6f26ahr 2381 20 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2381 21 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2381 22 secondary secondary JJ cord-028721-x6f26ahr 2381 23 to to IN cord-028721-x6f26ahr 2381 24 LH LH NNP cord-028721-x6f26ahr 2381 25 defi defi NNP cord-028721-x6f26ahr 2381 26 cit cit NNP cord-028721-x6f26ahr 2381 27 and and CC cord-028721-x6f26ahr 2381 28 in in IN cord-028721-x6f26ahr 2381 29 patients patient NNS cord-028721-x6f26ahr 2381 30 Infertility Infertility NNP cord-028721-x6f26ahr 2381 31 with with IN cord-028721-x6f26ahr 2381 32 biologically biologically RB cord-028721-x6f26ahr 2381 33 inactive inactive JJ cord-028721-x6f26ahr 2381 34 LH lh NN cord-028721-x6f26ahr 2381 35 . . . cord-028721-x6f26ahr 2382 1 Leydig leydig NN cord-028721-x6f26ahr 2382 2 cell cell NN cord-028721-x6f26ahr 2382 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2382 4 is be VBZ cord-028721-x6f26ahr 2382 5 very very RB cord-028721-x6f26ahr 2382 6 common common JJ cord-028721-x6f26ahr 2382 7 , , , cord-028721-x6f26ahr 2382 8 1040 1040 CD cord-028721-x6f26ahr 2382 9 and and CC cord-028721-x6f26ahr 2382 10 has have VBZ cord-028721-x6f26ahr 2382 11 been be VBN cord-028721-x6f26ahr 2382 12 observed observe VBN cord-028721-x6f26ahr 2382 13 in in IN cord-028721-x6f26ahr 2382 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2382 15 's 's POS cord-028721-x6f26ahr 2382 16 syndrome syndrome NN cord-028721-x6f26ahr 2382 17 , , , cord-028721-x6f26ahr 2382 18 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2382 19 , , , cord-028721-x6f26ahr 2382 20 male male JJ cord-028721-x6f26ahr 2382 21 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 2382 22 , , , cord-028721-x6f26ahr 2382 23 minor minor JJ cord-028721-x6f26ahr 2382 24 androgen androgen NN cord-028721-x6f26ahr 2382 25 insensitivity insensitivity NN cord-028721-x6f26ahr 2382 26 , , , cord-028721-x6f26ahr 2382 27 infertility infertility NN cord-028721-x6f26ahr 2382 28 secondary secondary JJ cord-028721-x6f26ahr 2382 29 to to IN cord-028721-x6f26ahr 2382 30 Leydig leydig NN cord-028721-x6f26ahr 2382 31 cell cell NN cord-028721-x6f26ahr 2382 32 dysfunction dysfunction NN cord-028721-x6f26ahr 2382 33 , , , cord-028721-x6f26ahr 2382 34 varicocele varicocele NN cord-028721-x6f26ahr 2382 35 , , , cord-028721-x6f26ahr 2382 36 after after IN cord-028721-x6f26ahr 2382 37 treatment treatment NN cord-028721-x6f26ahr 2382 38 with with IN cord-028721-x6f26ahr 2382 39 5αreductase 5αreductase CD cord-028721-x6f26ahr 2382 40 inhibitors inhibitor NNS cord-028721-x6f26ahr 2382 41 or or CC cord-028721-x6f26ahr 2382 42 non non JJ cord-028721-x6f26ahr 2382 43 - - JJ cord-028721-x6f26ahr 2382 44 steroidal steroidal JJ cord-028721-x6f26ahr 2382 45 anti anti JJ cord-028721-x6f26ahr 2382 46 - - NNS cord-028721-x6f26ahr 2382 47 androgens androgen NNS cord-028721-x6f26ahr 2382 48 , , , cord-028721-x6f26ahr 2382 49 and and CC cord-028721-x6f26ahr 2382 50 in in IN cord-028721-x6f26ahr 2382 51 some some DT cord-028721-x6f26ahr 2382 52 elderly elderly JJ cord-028721-x6f26ahr 2382 53 men man NNS cord-028721-x6f26ahr 2382 54 . . . cord-028721-x6f26ahr 2383 1 Such such JJ cord-028721-x6f26ahr 2383 2 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2383 3 may may MD cord-028721-x6f26ahr 2383 4 give give VB cord-028721-x6f26ahr 2383 5 rise rise NN cord-028721-x6f26ahr 2383 6 to to IN cord-028721-x6f26ahr 2383 7 hypoechoic hypoechoic NNP cord-028721-x6f26ahr 2383 8 or or CC cord-028721-x6f26ahr 2383 9 hyperechoic hyperechoic NNP cord-028721-x6f26ahr 2383 10 images image NNS cord-028721-x6f26ahr 2383 11 that that WDT cord-028721-x6f26ahr 2383 12 may may MD cord-028721-x6f26ahr 2383 13 be be VB cord-028721-x6f26ahr 2383 14 misdiagnosed misdiagnose VBN cord-028721-x6f26ahr 2383 15 as as IN cord-028721-x6f26ahr 2383 16 tumor tumor NN cord-028721-x6f26ahr 2383 17 . . . cord-028721-x6f26ahr 2384 1 1041 1041 CD cord-028721-x6f26ahr 2384 2 There there EX cord-028721-x6f26ahr 2384 3 is be VBZ cord-028721-x6f26ahr 2384 4 a a DT cord-028721-x6f26ahr 2384 5 close close JJ cord-028721-x6f26ahr 2384 6 relationship relationship NN cord-028721-x6f26ahr 2384 7 between between IN cord-028721-x6f26ahr 2384 8 testicular testicular JJ cord-028721-x6f26ahr 2384 9 dysfunction dysfunction NN cord-028721-x6f26ahr 2384 10 and and CC cord-028721-x6f26ahr 2384 11 elevated elevated JJ cord-028721-x6f26ahr 2384 12 mast mast JJ cord-028721-x6f26ahr 2384 13 cell cell NN cord-028721-x6f26ahr 2384 14 numbers number NNS cord-028721-x6f26ahr 2384 15 in in IN cord-028721-x6f26ahr 2384 16 the the DT cord-028721-x6f26ahr 2384 17 testis testis NN cord-028721-x6f26ahr 2384 18 . . . cord-028721-x6f26ahr 2385 1 An an DT cord-028721-x6f26ahr 2385 2 increase increase NN cord-028721-x6f26ahr 2385 3 in in IN cord-028721-x6f26ahr 2385 4 interstitial interstitial JJ cord-028721-x6f26ahr 2385 5 and and CC cord-028721-x6f26ahr 2385 6 peritubular peritubular NNP cord-028721-x6f26ahr 2385 7 mast mast NN cord-028721-x6f26ahr 2385 8 cells cell NNS cord-028721-x6f26ahr 2385 9 occasionally occasionally RB cord-028721-x6f26ahr 2385 10 occurs occur VBZ cord-028721-x6f26ahr 2385 11 in in IN cord-028721-x6f26ahr 2385 12 infertile infertile JJ cord-028721-x6f26ahr 2385 13 patients patient NNS cord-028721-x6f26ahr 2385 14 . . . cord-028721-x6f26ahr 2386 1 1042 1042 CD cord-028721-x6f26ahr 2386 2 , , , cord-028721-x6f26ahr 2386 3 1043 1043 CD cord-028721-x6f26ahr 2387 1 This this DT cord-028721-x6f26ahr 2387 2 increase increase NN cord-028721-x6f26ahr 2387 3 is be VBZ cord-028721-x6f26ahr 2387 4 higher high JJR cord-028721-x6f26ahr 2387 5 than than IN cord-028721-x6f26ahr 2387 6 that that DT cord-028721-x6f26ahr 2387 7 observed observe VBD cord-028721-x6f26ahr 2387 8 in in IN cord-028721-x6f26ahr 2387 9 infl infl NNP cord-028721-x6f26ahr 2387 10 ammatory ammatory NNP cord-028721-x6f26ahr 2387 11 or or CC cord-028721-x6f26ahr 2387 12 neoplastic neoplastic JJ cord-028721-x6f26ahr 2387 13 process process NN cord-028721-x6f26ahr 2387 14 . . . cord-028721-x6f26ahr 2388 1 1044 1044 CD cord-028721-x6f26ahr 2389 1 Daily Daily NNP cord-028721-x6f26ahr 2389 2 administration administration NN cord-028721-x6f26ahr 2389 3 of of IN cord-028721-x6f26ahr 2389 4 ketotifen ketotifen NNP cord-028721-x6f26ahr 2389 5 , , , cord-028721-x6f26ahr 2389 6 an an DT cord-028721-x6f26ahr 2389 7 antihistamine antihistamine NN cord-028721-x6f26ahr 2389 8 - - HYPH cord-028721-x6f26ahr 2389 9 like like JJ cord-028721-x6f26ahr 2389 10 drug drug NN cord-028721-x6f26ahr 2389 11 with with IN cord-028721-x6f26ahr 2389 12 a a DT cord-028721-x6f26ahr 2389 13 mast mast JJ cord-028721-x6f26ahr 2389 14 cell cell NN cord-028721-x6f26ahr 2389 15 - - HYPH cord-028721-x6f26ahr 2389 16 stabilizing stabilize VBG cord-028721-x6f26ahr 2389 17 effect effect NN cord-028721-x6f26ahr 2389 18 , , , cord-028721-x6f26ahr 2389 19 signifi signifi NNP cord-028721-x6f26ahr 2389 20 cantly cantly NNP cord-028721-x6f26ahr 2389 21 improves improve VBZ cord-028721-x6f26ahr 2389 22 the the DT cord-028721-x6f26ahr 2389 23 spermiogram spermiogram NNP cord-028721-x6f26ahr 2389 24 parameters parameter NNS cord-028721-x6f26ahr 2389 25 in in IN cord-028721-x6f26ahr 2389 26 some some DT cord-028721-x6f26ahr 2389 27 patients patient NNS cord-028721-x6f26ahr 2389 28 . . . cord-028721-x6f26ahr 2390 1 1045 1045 CD cord-028721-x6f26ahr 2391 1 For for IN cord-028721-x6f26ahr 2391 2 effective effective JJ cord-028721-x6f26ahr 2391 3 therapy therapy NN cord-028721-x6f26ahr 2391 4 , , , cord-028721-x6f26ahr 2391 5 it -PRON- PRP cord-028721-x6f26ahr 2391 6 is be VBZ cord-028721-x6f26ahr 2391 7 important important JJ cord-028721-x6f26ahr 2391 8 to to TO cord-028721-x6f26ahr 2391 9 know know VB cord-028721-x6f26ahr 2391 10 whether whether IN cord-028721-x6f26ahr 2391 11 or or CC cord-028721-x6f26ahr 2391 12 not not RB cord-028721-x6f26ahr 2391 13 the the DT cord-028721-x6f26ahr 2391 14 azoospermia azoospermia NN cord-028721-x6f26ahr 2391 15 or or CC cord-028721-x6f26ahr 2391 16 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2391 17 is be VBZ cord-028721-x6f26ahr 2391 18 the the DT cord-028721-x6f26ahr 2391 19 result result NN cord-028721-x6f26ahr 2391 20 of of IN cord-028721-x6f26ahr 2391 21 obstruction obstruction NN cord-028721-x6f26ahr 2391 22 . . . cord-028721-x6f26ahr 2392 1 863 863 CD cord-028721-x6f26ahr 2392 2 , , , cord-028721-x6f26ahr 2392 3 1046 1046 CD cord-028721-x6f26ahr 2392 4 Obstructive obstructive JJ cord-028721-x6f26ahr 2392 5 azoospermia azoospermia NN cord-028721-x6f26ahr 2392 6 and and CC cord-028721-x6f26ahr 2392 7 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2392 8 Azoospermia Azoospermia NNP cord-028721-x6f26ahr 2392 9 caused cause VBN cord-028721-x6f26ahr 2392 10 by by IN cord-028721-x6f26ahr 2392 11 obstruction obstruction NN cord-028721-x6f26ahr 2392 12 is be VBZ cord-028721-x6f26ahr 2392 13 usually usually RB cord-028721-x6f26ahr 2392 14 easily easily RB cord-028721-x6f26ahr 2392 15 diagnosed diagnose VBN cord-028721-x6f26ahr 2392 16 , , , cord-028721-x6f26ahr 2392 17 but but CC cord-028721-x6f26ahr 2392 18 this this DT cord-028721-x6f26ahr 2392 19 determination determination NN cord-028721-x6f26ahr 2392 20 is be VBZ cord-028721-x6f26ahr 2392 21 more more RBR cord-028721-x6f26ahr 2392 22 diffi diffi JJ cord-028721-x6f26ahr 2392 23 cult cult NN cord-028721-x6f26ahr 2392 24 with with IN cord-028721-x6f26ahr 2392 25 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2392 26 . . . cord-028721-x6f26ahr 2393 1 Obstruction obstruction NN cord-028721-x6f26ahr 2393 2 of of IN cord-028721-x6f26ahr 2393 3 the the DT cord-028721-x6f26ahr 2393 4 ductal ductal JJ cord-028721-x6f26ahr 2393 5 system system NN cord-028721-x6f26ahr 2393 6 should should MD cord-028721-x6f26ahr 2393 7 be be VB cord-028721-x6f26ahr 2393 8 suspected suspect VBN cord-028721-x6f26ahr 2393 9 when when WRB cord-028721-x6f26ahr 2393 10 there there EX cord-028721-x6f26ahr 2393 11 are be VBP cord-028721-x6f26ahr 2393 12 more more JJR cord-028721-x6f26ahr 2393 13 than than IN cord-028721-x6f26ahr 2393 14 20 20 CD cord-028721-x6f26ahr 2393 15 mature mature JJ cord-028721-x6f26ahr 2393 16 spermatids spermatid NNS cord-028721-x6f26ahr 2393 17 ( ( -LRB- cord-028721-x6f26ahr 2393 18 S s NN cord-028721-x6f26ahr 2393 19 c c NN cord-028721-x6f26ahr 2393 20 + + CC cord-028721-x6f26ahr 2393 21 S s NN cord-028721-x6f26ahr 2393 22 d d NN cord-028721-x6f26ahr 2393 23 ) ) -RRB- cord-028721-x6f26ahr 2393 24 per per IN cord-028721-x6f26ahr 2393 25 cross cross JJ cord-028721-x6f26ahr 2393 26 - - JJ cord-028721-x6f26ahr 2393 27 sectioned section VBN cord-028721-x6f26ahr 2393 28 tubule tubule NN cord-028721-x6f26ahr 2393 29 and and CC cord-028721-x6f26ahr 2393 30 fewer few JJR cord-028721-x6f26ahr 2393 31 than than IN cord-028721-x6f26ahr 2393 32 10 10 CD cord-028721-x6f26ahr 2393 33 million million CD cord-028721-x6f26ahr 2393 34 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2393 35 in in IN cord-028721-x6f26ahr 2393 36 the the DT cord-028721-x6f26ahr 2393 37 spermiogram spermiogram NNP cord-028721-x6f26ahr 2393 38 ( ( -LRB- cord-028721-x6f26ahr 2393 39 Fig Fig NNP cord-028721-x6f26ahr 2393 40 . . . cord-028721-x6f26ahr 2393 41 12 12 CD cord-028721-x6f26ahr 2393 42 - - SYM cord-028721-x6f26ahr 2393 43 118 118 CD cord-028721-x6f26ahr 2393 44 ) ) -RRB- cord-028721-x6f26ahr 2393 45 . . . cord-028721-x6f26ahr 2394 1 1047 1047 CD cord-028721-x6f26ahr 2394 2 , , , cord-028721-x6f26ahr 2394 3 1048 1048 CD cord-028721-x6f26ahr 2394 4 Obstructive obstructive JJ cord-028721-x6f26ahr 2394 5 azoospermia azoospermia NN cord-028721-x6f26ahr 2394 6 is be VBZ cord-028721-x6f26ahr 2394 7 implicated implicate VBN cord-028721-x6f26ahr 2394 8 in in IN cord-028721-x6f26ahr 2394 9 7.4 7.4 CD cord-028721-x6f26ahr 2394 10 - - HYPH cord-028721-x6f26ahr 2394 11 14.3 14.3 CD cord-028721-x6f26ahr 2394 12 % % NN cord-028721-x6f26ahr 2394 13 of of IN cord-028721-x6f26ahr 2394 14 cases case NNS cord-028721-x6f26ahr 2394 15 of of IN cord-028721-x6f26ahr 2394 16 male male JJ cord-028721-x6f26ahr 2394 17 infertility infertility NN cord-028721-x6f26ahr 2394 18 . . . cord-028721-x6f26ahr 2395 1 Obstruction obstruction NN cord-028721-x6f26ahr 2395 2 is be VBZ cord-028721-x6f26ahr 2395 3 classifi classifi NNP cord-028721-x6f26ahr 2395 4 ed ed NNP cord-028721-x6f26ahr 2395 5 as as IN cord-028721-x6f26ahr 2395 6 proximal proximal JJ cord-028721-x6f26ahr 2395 7 , , , cord-028721-x6f26ahr 2395 8 distal distal JJ cord-028721-x6f26ahr 2395 9 , , , cord-028721-x6f26ahr 2395 10 and and CC cord-028721-x6f26ahr 2395 11 mixed mixed JJ cord-028721-x6f26ahr 2395 12 , , , cord-028721-x6f26ahr 2395 13 according accord VBG cord-028721-x6f26ahr 2395 14 to to IN cord-028721-x6f26ahr 2395 15 the the DT cord-028721-x6f26ahr 2395 16 distance distance NN cord-028721-x6f26ahr 2395 17 from from IN cord-028721-x6f26ahr 2395 18 the the DT cord-028721-x6f26ahr 2395 19 testis testis NN cord-028721-x6f26ahr 2395 20 to to IN cord-028721-x6f26ahr 2395 21 the the DT cord-028721-x6f26ahr 2395 22 point point NN cord-028721-x6f26ahr 2395 23 of of IN cord-028721-x6f26ahr 2395 24 obstruction obstruction NN cord-028721-x6f26ahr 2395 25 in in IN cord-028721-x6f26ahr 2395 26 the the DT cord-028721-x6f26ahr 2395 27 ductal ductal JJ cord-028721-x6f26ahr 2395 28 system system NN cord-028721-x6f26ahr 2395 29 . . . cord-028721-x6f26ahr 2396 1 Proximal proximal JJ cord-028721-x6f26ahr 2396 2 obstruction obstruction NN cord-028721-x6f26ahr 2396 3 Obstruction obstruction NN cord-028721-x6f26ahr 2396 4 is be VBZ cord-028721-x6f26ahr 2396 5 considered consider VBN cord-028721-x6f26ahr 2396 6 proximal proximal JJ cord-028721-x6f26ahr 2396 7 when when WRB cord-028721-x6f26ahr 2396 8 the the DT cord-028721-x6f26ahr 2396 9 lesion lesion NN cord-028721-x6f26ahr 2396 10 lies lie VBZ cord-028721-x6f26ahr 2396 11 between between IN cord-028721-x6f26ahr 2396 12 the the DT cord-028721-x6f26ahr 2396 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2396 14 tubules tubule NNS cord-028721-x6f26ahr 2396 15 and and CC cord-028721-x6f26ahr 2396 16 the the DT cord-028721-x6f26ahr 2396 17 distal distal JJ cord-028721-x6f26ahr 2396 18 end end NN cord-028721-x6f26ahr 2396 19 of of IN cord-028721-x6f26ahr 2396 20 the the DT cord-028721-x6f26ahr 2396 21 ampulla ampulla NN cord-028721-x6f26ahr 2396 22 of of IN cord-028721-x6f26ahr 2396 23 the the DT cord-028721-x6f26ahr 2396 24 vas vas NNP cord-028721-x6f26ahr 2396 25 deferens deferen NNS cord-028721-x6f26ahr 2396 26 . . . cord-028721-x6f26ahr 2397 1 Epididymal Epididymal NNP cord-028721-x6f26ahr 2397 2 obstruction obstruction NN cord-028721-x6f26ahr 2397 3 , , , cord-028721-x6f26ahr 2397 4 principally principally RB cord-028721-x6f26ahr 2397 5 of of IN cord-028721-x6f26ahr 2397 6 the the DT cord-028721-x6f26ahr 2397 7 caput caput NNP cord-028721-x6f26ahr 2397 8 - - HYPH cord-028721-x6f26ahr 2397 9 corpus corpus NNP cord-028721-x6f26ahr 2397 10 transition transition NN cord-028721-x6f26ahr 2397 11 zone zone NN cord-028721-x6f26ahr 2397 12 , , , cord-028721-x6f26ahr 2397 13 accounts account VBZ cord-028721-x6f26ahr 2397 14 for for IN cord-028721-x6f26ahr 2397 15 66 66 CD cord-028721-x6f26ahr 2397 16 % % NN cord-028721-x6f26ahr 2397 17 of of IN cord-028721-x6f26ahr 2397 18 cases case NNS cord-028721-x6f26ahr 2397 19 . . . cord-028721-x6f26ahr 2398 1 Rarely rarely RB cord-028721-x6f26ahr 2398 2 , , , cord-028721-x6f26ahr 2398 3 there there EX cord-028721-x6f26ahr 2398 4 is be VBZ cord-028721-x6f26ahr 2398 5 a a DT cord-028721-x6f26ahr 2398 6 defective defective JJ cord-028721-x6f26ahr 2398 7 connection connection NN cord-028721-x6f26ahr 2398 8 between between IN cord-028721-x6f26ahr 2398 9 the the DT cord-028721-x6f26ahr 2398 10 rete rete NN cord-028721-x6f26ahr 2398 11 testis testis NN cord-028721-x6f26ahr 2398 12 and and CC cord-028721-x6f26ahr 2398 13 epididymal epididymal NNP cord-028721-x6f26ahr 2398 14 ductuli ductuli NNP cord-028721-x6f26ahr 2398 15 efferentes efferentes NNPS cord-028721-x6f26ahr 2398 16 . . . cord-028721-x6f26ahr 2399 1 Because because IN cord-028721-x6f26ahr 2399 2 the the DT cord-028721-x6f26ahr 2399 3 seminal seminal JJ cord-028721-x6f26ahr 2399 4 vesicles vesicle NNS cord-028721-x6f26ahr 2399 5 are be VBP cord-028721-x6f26ahr 2399 6 normal normal JJ cord-028721-x6f26ahr 2399 7 , , , cord-028721-x6f26ahr 2399 8 men man NNS cord-028721-x6f26ahr 2399 9 with with IN cord-028721-x6f26ahr 2399 10 proximal proximal JJ cord-028721-x6f26ahr 2399 11 obstruction obstruction NN cord-028721-x6f26ahr 2399 12 have have VBP cord-028721-x6f26ahr 2399 13 a a DT cord-028721-x6f26ahr 2399 14 normal normal JJ cord-028721-x6f26ahr 2399 15 volume volume NN cord-028721-x6f26ahr 2399 16 of of IN cord-028721-x6f26ahr 2399 17 semen semen NN cord-028721-x6f26ahr 2399 18 ( ( -LRB- cord-028721-x6f26ahr 2399 19 the the DT cord-028721-x6f26ahr 2399 20 testicular testicular JJ cord-028721-x6f26ahr 2399 21 contribution contribution NN cord-028721-x6f26ahr 2399 22 to to IN cord-028721-x6f26ahr 2399 23 semen semen NN cord-028721-x6f26ahr 2399 24 is be VBZ cord-028721-x6f26ahr 2399 25 about about RB cord-028721-x6f26ahr 2399 26 5 5 CD cord-028721-x6f26ahr 2399 27 % % NN cord-028721-x6f26ahr 2399 28 of of IN cord-028721-x6f26ahr 2399 29 the the DT cord-028721-x6f26ahr 2399 30 total total JJ cord-028721-x6f26ahr 2399 31 volume volume NN cord-028721-x6f26ahr 2399 32 ) ) -RRB- cord-028721-x6f26ahr 2399 33 . . . cord-028721-x6f26ahr 2400 1 When when WRB cord-028721-x6f26ahr 2400 2 obstruction obstruction NN cord-028721-x6f26ahr 2400 3 is be VBZ cord-028721-x6f26ahr 2400 4 in in IN cord-028721-x6f26ahr 2400 5 the the DT cord-028721-x6f26ahr 2400 6 cauda cauda NN cord-028721-x6f26ahr 2400 7 of of IN cord-028721-x6f26ahr 2400 8 the the DT cord-028721-x6f26ahr 2400 9 epididymis epididymis NN cord-028721-x6f26ahr 2400 10 , , , cord-028721-x6f26ahr 2400 11 epididymal epididymal JJ cord-028721-x6f26ahr 2400 12 markers marker NNS cord-028721-x6f26ahr 2400 13 , , , cord-028721-x6f26ahr 2400 14 including include VBG cord-028721-x6f26ahr 2400 15 carnitine carnitine NN cord-028721-x6f26ahr 2400 16 , , , cord-028721-x6f26ahr 2400 17 glycerophosphorylcholine glycerophosphorylcholine NN cord-028721-x6f26ahr 2400 18 and and CC cord-028721-x6f26ahr 2400 19 α α NN cord-028721-x6f26ahr 2400 20 - - HYPH cord-028721-x6f26ahr 2400 21 glycosidase glycosidase NN cord-028721-x6f26ahr 2400 22 are be VBP cord-028721-x6f26ahr 2400 23 low low JJ cord-028721-x6f26ahr 2400 24 . . . cord-028721-x6f26ahr 2401 1 1049 1049 CD cord-028721-x6f26ahr 2402 1 The the DT cord-028721-x6f26ahr 2402 2 nearer near JJR cord-028721-x6f26ahr 2402 3 the the DT cord-028721-x6f26ahr 2402 4 obstruction obstruction NN cord-028721-x6f26ahr 2402 5 is be VBZ cord-028721-x6f26ahr 2402 6 to to IN cord-028721-x6f26ahr 2402 7 the the DT cord-028721-x6f26ahr 2402 8 caput caput NN cord-028721-x6f26ahr 2402 9 of of IN cord-028721-x6f26ahr 2402 10 the the DT cord-028721-x6f26ahr 2402 11 epididymis epididymis NN cord-028721-x6f26ahr 2402 12 , , , cord-028721-x6f26ahr 2402 13 the the DT cord-028721-x6f26ahr 2402 14 higher high JJR cord-028721-x6f26ahr 2402 15 the the DT cord-028721-x6f26ahr 2402 16 level level NN cord-028721-x6f26ahr 2402 17 of of IN cord-028721-x6f26ahr 2402 18 these these DT cord-028721-x6f26ahr 2402 19 markers marker NNS cord-028721-x6f26ahr 2402 20 . . . cord-028721-x6f26ahr 2403 1 Distal distal JJ cord-028721-x6f26ahr 2403 2 obstruction obstruction NN cord-028721-x6f26ahr 2403 3 Distal distal JJ cord-028721-x6f26ahr 2403 4 obstruction obstruction NN cord-028721-x6f26ahr 2403 5 is be VBZ cord-028721-x6f26ahr 2403 6 located locate VBN cord-028721-x6f26ahr 2403 7 between between IN cord-028721-x6f26ahr 2403 8 the the DT cord-028721-x6f26ahr 2403 9 ampulla ampulla NN cord-028721-x6f26ahr 2403 10 of of IN cord-028721-x6f26ahr 2403 11 the the DT cord-028721-x6f26ahr 2403 12 vas vas NNP cord-028721-x6f26ahr 2403 13 deferens deferens NNP cord-028721-x6f26ahr 2403 14 and and CC cord-028721-x6f26ahr 2403 15 the the DT cord-028721-x6f26ahr 2403 16 junction junction NN cord-028721-x6f26ahr 2403 17 of of IN cord-028721-x6f26ahr 2403 18 the the DT cord-028721-x6f26ahr 2403 19 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2403 20 ducts duct NNS cord-028721-x6f26ahr 2403 21 and and CC cord-028721-x6f26ahr 2403 22 urethra urethra NN cord-028721-x6f26ahr 2403 23 . . . cord-028721-x6f26ahr 2404 1 These these DT cord-028721-x6f26ahr 2404 2 patients patient NNS cord-028721-x6f26ahr 2404 3 present present JJ cord-028721-x6f26ahr 2404 4 with with IN cord-028721-x6f26ahr 2404 5 sacral sacral JJ cord-028721-x6f26ahr 2404 6 , , , cord-028721-x6f26ahr 2404 7 perineal perineal NN cord-028721-x6f26ahr 2404 8 , , , cord-028721-x6f26ahr 2404 9 or or CC cord-028721-x6f26ahr 2404 10 scrotal scrotal JJ cord-028721-x6f26ahr 2404 11 pain pain NN cord-028721-x6f26ahr 2404 12 on on IN cord-028721-x6f26ahr 2404 13 ejaculation ejaculation NN cord-028721-x6f26ahr 2404 14 . . . cord-028721-x6f26ahr 2405 1 Rectal rectal JJ cord-028721-x6f26ahr 2405 2 examination examination NN cord-028721-x6f26ahr 2405 3 often often RB cord-028721-x6f26ahr 2405 4 reveals reveal VBZ cord-028721-x6f26ahr 2405 5 enlarged enlarge VBN cord-028721-x6f26ahr 2405 6 seminal seminal JJ cord-028721-x6f26ahr 2405 7 vesicles vesicle NNS cord-028721-x6f26ahr 2405 8 . . . cord-028721-x6f26ahr 2406 1 The the DT cord-028721-x6f26ahr 2406 2 volume volume NN cord-028721-x6f26ahr 2406 3 of of IN cord-028721-x6f26ahr 2406 4 semen semen NN cord-028721-x6f26ahr 2406 5 is be VBZ cord-028721-x6f26ahr 2406 6 low low JJ cord-028721-x6f26ahr 2406 7 and and CC cord-028721-x6f26ahr 2406 8 consists consist VBZ cord-028721-x6f26ahr 2406 9 of of IN cord-028721-x6f26ahr 2406 10 watery watery JJ cord-028721-x6f26ahr 2406 11 fl fl JJ cord-028721-x6f26ahr 2406 12 uid uid NN cord-028721-x6f26ahr 2406 13 that that WDT cord-028721-x6f26ahr 2406 14 fails fail VBZ cord-028721-x6f26ahr 2406 15 to to TO cord-028721-x6f26ahr 2406 16 coagulate coagulate VB cord-028721-x6f26ahr 2406 17 . . . cord-028721-x6f26ahr 2407 1 Seminal seminal JJ cord-028721-x6f26ahr 2407 2 vesicle vesicle NN cord-028721-x6f26ahr 2407 3 secretions secretion NNS cord-028721-x6f26ahr 2407 4 are be VBP cord-028721-x6f26ahr 2407 5 lacking lack VBG cord-028721-x6f26ahr 2407 6 . . . cord-028721-x6f26ahr 2408 1 The the DT cord-028721-x6f26ahr 2408 2 concentration concentration NN cord-028721-x6f26ahr 2408 3 of of IN cord-028721-x6f26ahr 2408 4 prostatic prostatic JJ cord-028721-x6f26ahr 2408 5 secretions secretion NNS cord-028721-x6f26ahr 2408 6 , , , cord-028721-x6f26ahr 2408 7 such such JJ cord-028721-x6f26ahr 2408 8 as as IN cord-028721-x6f26ahr 2408 9 acid acid NN cord-028721-x6f26ahr 2408 10 phosphatase phosphatase NN cord-028721-x6f26ahr 2408 11 and and CC cord-028721-x6f26ahr 2408 12 citric citric NN cord-028721-x6f26ahr 2408 13 acid acid NN cord-028721-x6f26ahr 2408 14 , , , cord-028721-x6f26ahr 2408 15 is be VBZ cord-028721-x6f26ahr 2408 16 increased increase VBN cord-028721-x6f26ahr 2408 17 owing owe VBG cord-028721-x6f26ahr 2408 18 to to IN cord-028721-x6f26ahr 2408 19 the the DT cord-028721-x6f26ahr 2408 20 lack lack NN cord-028721-x6f26ahr 2408 21 of of IN cord-028721-x6f26ahr 2408 22 semen semen NN cord-028721-x6f26ahr 2408 23 dilution dilution NN cord-028721-x6f26ahr 2408 24 . . . cord-028721-x6f26ahr 2409 1 Vasography Vasography NNP cord-028721-x6f26ahr 2409 2 may may MD cord-028721-x6f26ahr 2409 3 help help VB cord-028721-x6f26ahr 2409 4 in in IN cord-028721-x6f26ahr 2409 5 diagnosis diagnosis NN cord-028721-x6f26ahr 2409 6 , , , cord-028721-x6f26ahr 2409 7 as as IN cord-028721-x6f26ahr 2409 8 higher high JJR cord-028721-x6f26ahr 2409 9 segments segment NNS cord-028721-x6f26ahr 2409 10 fail fail VBP cord-028721-x6f26ahr 2409 11 to to TO cord-028721-x6f26ahr 2409 12 fi fi VB cord-028721-x6f26ahr 2409 13 ll will NNP cord-028721-x6f26ahr 2409 14 . . . cord-028721-x6f26ahr 2410 1 1050 1050 CD cord-028721-x6f26ahr 2411 1 Transrectal transrectal JJ cord-028721-x6f26ahr 2411 2 ultrasonography ultrasonography NN cord-028721-x6f26ahr 2411 3 is be VBZ cord-028721-x6f26ahr 2411 4 the the DT cord-028721-x6f26ahr 2411 5 most most RBS cord-028721-x6f26ahr 2411 6 accurate accurate JJ cord-028721-x6f26ahr 2411 7 imaging imaging NN cord-028721-x6f26ahr 2411 8 modality modality NN cord-028721-x6f26ahr 2411 9 for for IN cord-028721-x6f26ahr 2411 10 the the DT cord-028721-x6f26ahr 2411 11 diagnosis diagnosis NN cord-028721-x6f26ahr 2411 12 of of IN cord-028721-x6f26ahr 2411 13 ejaculatory ejaculatory NNP cord-028721-x6f26ahr 2411 14 duct duct NN cord-028721-x6f26ahr 2411 15 obstruction obstruction NN cord-028721-x6f26ahr 2411 16 . . . cord-028721-x6f26ahr 2412 1 Needle needle NN cord-028721-x6f26ahr 2412 2 aspiration aspiration NN cord-028721-x6f26ahr 2412 3 of of IN cord-028721-x6f26ahr 2412 4 seminal seminal JJ cord-028721-x6f26ahr 2412 5 vesicle vesicle NN cord-028721-x6f26ahr 2412 6 fl fl NNP cord-028721-x6f26ahr 2412 7 uid uid NN cord-028721-x6f26ahr 2412 8 may may MD cord-028721-x6f26ahr 2412 9 show show VB cord-028721-x6f26ahr 2412 10 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2412 11 that that WDT cord-028721-x6f26ahr 2412 12 have have VBP cord-028721-x6f26ahr 2412 13 entered enter VBN cord-028721-x6f26ahr 2412 14 the the DT cord-028721-x6f26ahr 2412 15 seminal seminal JJ cord-028721-x6f26ahr 2412 16 vesicles vesicle NNS cord-028721-x6f26ahr 2412 17 by by IN cord-028721-x6f26ahr 2412 18 refl refl NNP cord-028721-x6f26ahr 2412 19 ux ux NNP cord-028721-x6f26ahr 2412 20 . . . cord-028721-x6f26ahr 2413 1 Mixed mixed JJ cord-028721-x6f26ahr 2413 2 obstruction obstruction NN cord-028721-x6f26ahr 2413 3 Mixed mixed JJ cord-028721-x6f26ahr 2413 4 obstruction obstruction NN cord-028721-x6f26ahr 2413 5 refers refer VBZ cord-028721-x6f26ahr 2413 6 to to IN cord-028721-x6f26ahr 2413 7 lack lack NN cord-028721-x6f26ahr 2413 8 of of IN cord-028721-x6f26ahr 2413 9 patency patency NN cord-028721-x6f26ahr 2413 10 of of IN cord-028721-x6f26ahr 2413 11 the the DT cord-028721-x6f26ahr 2413 12 vas vas NNP cord-028721-x6f26ahr 2413 13 deferens deferen NNS cord-028721-x6f26ahr 2413 14 or or CC cord-028721-x6f26ahr 2413 15 the the DT cord-028721-x6f26ahr 2413 16 epididymis epididymis NN cord-028721-x6f26ahr 2413 17 and and CC cord-028721-x6f26ahr 2413 18 alterations alteration NNS cord-028721-x6f26ahr 2413 19 in in IN cord-028721-x6f26ahr 2413 20 the the DT cord-028721-x6f26ahr 2413 21 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2413 22 ducts duct NNS cord-028721-x6f26ahr 2413 23 or or CC cord-028721-x6f26ahr 2413 24 seminal seminal JJ cord-028721-x6f26ahr 2413 25 vesicles vesicle NNS cord-028721-x6f26ahr 2413 26 ( ( -LRB- cord-028721-x6f26ahr 2413 27 low low JJ cord-028721-x6f26ahr 2413 28 ejaculate ejaculate NN cord-028721-x6f26ahr 2413 29 volume volume NN cord-028721-x6f26ahr 2413 30 , , , cord-028721-x6f26ahr 2413 31 and and CC cord-028721-x6f26ahr 2413 32 absence absence NN cord-028721-x6f26ahr 2413 33 of of IN cord-028721-x6f26ahr 2413 34 fructose fructose NN cord-028721-x6f26ahr 2413 35 ) ) -RRB- cord-028721-x6f26ahr 2413 36 . . . cord-028721-x6f26ahr 2414 1 The the DT cord-028721-x6f26ahr 2414 2 most most RBS cord-028721-x6f26ahr 2414 3 frequent frequent JJ cord-028721-x6f26ahr 2414 4 cause cause NN cord-028721-x6f26ahr 2414 5 is be VBZ cord-028721-x6f26ahr 2414 6 mucoviscidosis mucoviscidosis NN cord-028721-x6f26ahr 2414 7 . . . cord-028721-x6f26ahr 2415 1 One one CD cord-028721-x6f26ahr 2415 2 - - HYPH cord-028721-x6f26ahr 2415 3 third third NN cord-028721-x6f26ahr 2415 4 of of IN cord-028721-x6f26ahr 2415 5 patients patient NNS cord-028721-x6f26ahr 2415 6 with with IN cord-028721-x6f26ahr 2415 7 congenital congenital JJ cord-028721-x6f26ahr 2415 8 bilateral bilateral JJ cord-028721-x6f26ahr 2415 9 absence absence NN cord-028721-x6f26ahr 2415 10 of of IN cord-028721-x6f26ahr 2415 11 the the DT cord-028721-x6f26ahr 2415 12 vas vas NNP cord-028721-x6f26ahr 2415 13 deferens deferen NNS cord-028721-x6f26ahr 2415 14 have have VBP cord-028721-x6f26ahr 2415 15 agenesis agenesis NN cord-028721-x6f26ahr 2415 16 or or CC cord-028721-x6f26ahr 2415 17 hypoplasia hypoplasia NN cord-028721-x6f26ahr 2415 18 of of IN cord-028721-x6f26ahr 2415 19 the the DT cord-028721-x6f26ahr 2415 20 seminal seminal JJ cord-028721-x6f26ahr 2415 21 vesicles vesicle NNS cord-028721-x6f26ahr 2415 22 . . . cord-028721-x6f26ahr 2416 1 The the DT cord-028721-x6f26ahr 2416 2 cause cause NN cord-028721-x6f26ahr 2416 3 of of IN cord-028721-x6f26ahr 2416 4 epididymal epididymal JJ cord-028721-x6f26ahr 2416 5 obstruction obstruction NN cord-028721-x6f26ahr 2416 6 in in IN cord-028721-x6f26ahr 2416 7 patients patient NNS cord-028721-x6f26ahr 2416 8 with with IN cord-028721-x6f26ahr 2416 9 anomalies anomaly NNS cord-028721-x6f26ahr 2416 10 of of IN cord-028721-x6f26ahr 2416 11 the the DT cord-028721-x6f26ahr 2416 12 prostate prostate NN cord-028721-x6f26ahr 2416 13 - - HYPH cord-028721-x6f26ahr 2416 14 vesiculo vesiculo NN cord-028721-x6f26ahr 2416 15 - - HYPH cord-028721-x6f26ahr 2416 16 deferential deferential JJ cord-028721-x6f26ahr 2416 17 junctions junction NNS cord-028721-x6f26ahr 2416 18 is be VBZ cord-028721-x6f26ahr 2416 19 diffi diffi JJ cord-028721-x6f26ahr 2416 20 cult cult NN cord-028721-x6f26ahr 2416 21 to to TO cord-028721-x6f26ahr 2416 22 determine determine VB cord-028721-x6f26ahr 2416 23 . . . cord-028721-x6f26ahr 2417 1 Etiology etiology NN cord-028721-x6f26ahr 2417 2 of of IN cord-028721-x6f26ahr 2417 3 obstructive obstructive JJ cord-028721-x6f26ahr 2417 4 azoospermia azoospermia NN cord-028721-x6f26ahr 2417 5 Obstructive obstructive JJ cord-028721-x6f26ahr 2417 6 azoospermia azoospermia NN cord-028721-x6f26ahr 2417 7 may may MD cord-028721-x6f26ahr 2417 8 be be VB cord-028721-x6f26ahr 2417 9 caused cause VBN cord-028721-x6f26ahr 2417 10 by by IN cord-028721-x6f26ahr 2417 11 congenital congenital JJ cord-028721-x6f26ahr 2417 12 or or CC cord-028721-x6f26ahr 2417 13 acquired acquire VBN cord-028721-x6f26ahr 2417 14 lesions lesion NNS cord-028721-x6f26ahr 2417 15 . . . cord-028721-x6f26ahr 2418 1 Congenital congenital JJ cord-028721-x6f26ahr 2418 2 azoospermia azoospermia NN cord-028721-x6f26ahr 2419 1 The the DT cord-028721-x6f26ahr 2419 2 most most RBS cord-028721-x6f26ahr 2419 3 frequent frequent JJ cord-028721-x6f26ahr 2419 4 anomalies anomaly NNS cord-028721-x6f26ahr 2419 5 associated associate VBN cord-028721-x6f26ahr 2419 6 with with IN cord-028721-x6f26ahr 2419 7 congenital congenital JJ cord-028721-x6f26ahr 2419 8 azoospermia azoospermia NN cord-028721-x6f26ahr 2419 9 are be VBP cord-028721-x6f26ahr 2419 10 testis testis NN cord-028721-x6f26ahr 2419 11 - - HYPH cord-028721-x6f26ahr 2419 12 epididymis epididymis NN cord-028721-x6f26ahr 2419 13 dissociation dissociation NN cord-028721-x6f26ahr 2419 14 , , , cord-028721-x6f26ahr 2419 15 epididymal epididymal JJ cord-028721-x6f26ahr 2419 16 malformation malformation NN cord-028721-x6f26ahr 2419 17 in in IN cord-028721-x6f26ahr 2419 18 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2419 19 , , , cord-028721-x6f26ahr 2419 20 bilateral bilateral JJ cord-028721-x6f26ahr 2419 21 absence absence NN cord-028721-x6f26ahr 2419 22 of of IN cord-028721-x6f26ahr 2419 23 the the DT cord-028721-x6f26ahr 2419 24 vas vas NNP cord-028721-x6f26ahr 2419 25 deferens deferen NNS cord-028721-x6f26ahr 2419 26 , , , cord-028721-x6f26ahr 2419 27 congenital congenital JJ cord-028721-x6f26ahr 2419 28 unilateral unilateral JJ cord-028721-x6f26ahr 2419 29 absence absence NN cord-028721-x6f26ahr 2419 30 of of IN cord-028721-x6f26ahr 2419 31 the the DT cord-028721-x6f26ahr 2419 32 vas vas FW cord-028721-x6f26ahr 2419 33 deferens deferen NNS cord-028721-x6f26ahr 2419 34 associated associate VBN cord-028721-x6f26ahr 2419 35 with with IN cord-028721-x6f26ahr 2419 36 pathology pathology NN cord-028721-x6f26ahr 2419 37 of of IN cord-028721-x6f26ahr 2419 38 the the DT cord-028721-x6f26ahr 2419 39 contralateral contralateral JJ cord-028721-x6f26ahr 2419 40 testis testis NN cord-028721-x6f26ahr 2419 41 or or CC cord-028721-x6f26ahr 2419 42 its -PRON- PRP$ cord-028721-x6f26ahr 2419 43 sperm sperm NN cord-028721-x6f26ahr 2419 44 excretory excretory JJ cord-028721-x6f26ahr 2419 45 ducts duct NNS cord-028721-x6f26ahr 2419 46 , , , cord-028721-x6f26ahr 2419 47 seminal seminal JJ cord-028721-x6f26ahr 2419 48 vesicle vesicle NN cord-028721-x6f26ahr 2419 49 agenesis agenesis NN cord-028721-x6f26ahr 2419 50 , , , cord-028721-x6f26ahr 2419 51 and and CC cord-028721-x6f26ahr 2419 52 ejaculatory ejaculatory JJ cord-028721-x6f26ahr 2419 53 duct duct NN cord-028721-x6f26ahr 2419 54 obstruction obstruction NN cord-028721-x6f26ahr 2420 1 ( ( -LRB- cord-028721-x6f26ahr 2420 2 Table table NN cord-028721-x6f26ahr 2420 3 _SP cord-028721-x6f26ahr 2420 4 12 12 CD cord-028721-x6f26ahr 2420 5 - - SYM cord-028721-x6f26ahr 2420 6 9 9 CD cord-028721-x6f26ahr 2420 7 ) ) -RRB- cord-028721-x6f26ahr 2420 8 . . . cord-028721-x6f26ahr 2421 1 Agenesis Agenesis NNP cord-028721-x6f26ahr 2421 2 of of IN cord-028721-x6f26ahr 2421 3 all all DT cord-028721-x6f26ahr 2421 4 mesonephric mesonephric JJ cord-028721-x6f26ahr 2421 5 duct duct NN cord-028721-x6f26ahr 2421 6 derivatives derivative NNS cord-028721-x6f26ahr 2421 7 . . . cord-028721-x6f26ahr 2422 1 Agenesis Agenesis NNP cord-028721-x6f26ahr 2422 2 of of IN cord-028721-x6f26ahr 2422 3 all all DT cord-028721-x6f26ahr 2422 4 mesonephric mesonephric JJ cord-028721-x6f26ahr 2422 5 duct duct NN cord-028721-x6f26ahr 2422 6 derivatives derivative NNS cord-028721-x6f26ahr 2422 7 is be VBZ cord-028721-x6f26ahr 2422 8 a a DT cord-028721-x6f26ahr 2422 9 rare rare JJ cord-028721-x6f26ahr 2422 10 disorder disorder NN cord-028721-x6f26ahr 2422 11 that that WDT cord-028721-x6f26ahr 2422 12 gives give VBZ cord-028721-x6f26ahr 2422 13 rise rise NN cord-028721-x6f26ahr 2422 14 to to IN cord-028721-x6f26ahr 2422 15 varied varied JJ cord-028721-x6f26ahr 2422 16 anatomical anatomical JJ cord-028721-x6f26ahr 2422 17 anomalies anomaly NNS cord-028721-x6f26ahr 2422 18 , , , cord-028721-x6f26ahr 2422 19 depending depend VBG cord-028721-x6f26ahr 2422 20 on on IN cord-028721-x6f26ahr 2422 21 the the DT cord-028721-x6f26ahr 2422 22 stage stage NN cord-028721-x6f26ahr 2422 23 of of IN cord-028721-x6f26ahr 2422 24 embryonic embryonic JJ cord-028721-x6f26ahr 2422 25 development development NN cord-028721-x6f26ahr 2422 26 at at IN cord-028721-x6f26ahr 2422 27 which which WDT cord-028721-x6f26ahr 2422 28 the the DT cord-028721-x6f26ahr 2422 29 mesonephric mesonephric JJ cord-028721-x6f26ahr 2422 30 duct duct NN cord-028721-x6f26ahr 2422 31 derivatives derivative NNS cord-028721-x6f26ahr 2422 32 disappear disappear VBP cord-028721-x6f26ahr 2422 33 . . . cord-028721-x6f26ahr 2423 1 If if IN cord-028721-x6f26ahr 2423 2 failure failure NN cord-028721-x6f26ahr 2423 3 occurs occur VBZ cord-028721-x6f26ahr 2423 4 before before IN cord-028721-x6f26ahr 2423 5 the the DT cord-028721-x6f26ahr 2423 6 fourth fourth JJ cord-028721-x6f26ahr 2423 7 week week NN cord-028721-x6f26ahr 2423 8 the the DT cord-028721-x6f26ahr 2423 9 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2423 10 kidney kidney NN cord-028721-x6f26ahr 2423 11 and and CC cord-028721-x6f26ahr 2423 12 ureter ureter NN cord-028721-x6f26ahr 2423 13 are be VBP cord-028721-x6f26ahr 2423 14 absent absent JJ cord-028721-x6f26ahr 2423 15 , , , cord-028721-x6f26ahr 2423 16 although although IN cord-028721-x6f26ahr 2423 17 the the DT cord-028721-x6f26ahr 2423 18 testis testis NN cord-028721-x6f26ahr 2423 19 may may MD cord-028721-x6f26ahr 2423 20 be be VB cord-028721-x6f26ahr 2423 21 present present JJ cord-028721-x6f26ahr 2423 22 , , , cord-028721-x6f26ahr 2423 23 or or CC cord-028721-x6f26ahr 2423 24 there there EX cord-028721-x6f26ahr 2423 25 may may MD cord-028721-x6f26ahr 2423 26 be be VB cord-028721-x6f26ahr 2423 27 other other JJ cord-028721-x6f26ahr 2423 28 renal renal JJ cord-028721-x6f26ahr 2423 29 anomalies anomaly NNS cord-028721-x6f26ahr 2423 30 . . . cord-028721-x6f26ahr 2424 1 If if IN cord-028721-x6f26ahr 2424 2 failure failure NN cord-028721-x6f26ahr 2424 3 occurs occur VBZ cord-028721-x6f26ahr 2424 4 in in IN cord-028721-x6f26ahr 2424 5 the the DT cord-028721-x6f26ahr 2424 6 fourth fourth JJ cord-028721-x6f26ahr 2424 7 week week NN cord-028721-x6f26ahr 2424 8 , , , cord-028721-x6f26ahr 2424 9 and and CC cord-028721-x6f26ahr 2424 10 the the DT cord-028721-x6f26ahr 2424 11 ureteral ureteral JJ cord-028721-x6f26ahr 2424 12 bud bud NN cord-028721-x6f26ahr 2424 13 is be VBZ cord-028721-x6f26ahr 2424 14 already already RB cord-028721-x6f26ahr 2424 15 formed form VBN cord-028721-x6f26ahr 2424 16 , , , cord-028721-x6f26ahr 2424 17 the the DT cord-028721-x6f26ahr 2424 18 ureter ureter NN cord-028721-x6f26ahr 2424 19 and and CC cord-028721-x6f26ahr 2424 20 kidney kidney NN cord-028721-x6f26ahr 2424 21 may may MD cord-028721-x6f26ahr 2424 22 develop develop VB cord-028721-x6f26ahr 2424 23 normally normally RB cord-028721-x6f26ahr 2424 24 . . . cord-028721-x6f26ahr 2425 1 If if IN cord-028721-x6f26ahr 2425 2 failure failure NN cord-028721-x6f26ahr 2425 3 occurs occur VBZ cord-028721-x6f26ahr 2425 4 between between IN cord-028721-x6f26ahr 2425 5 the the DT cord-028721-x6f26ahr 2425 6 fourth fourth JJ cord-028721-x6f26ahr 2425 7 and and CC cord-028721-x6f26ahr 2425 8 the the DT cord-028721-x6f26ahr 2425 9 13th 13th JJ cord-028721-x6f26ahr 2425 10 weeks week NNS cord-028721-x6f26ahr 2425 11 , , , cord-028721-x6f26ahr 2425 12 there there EX cord-028721-x6f26ahr 2425 13 is be VBZ cord-028721-x6f26ahr 2425 14 a a DT cord-028721-x6f26ahr 2425 15 variable variable JJ cord-028721-x6f26ahr 2425 16 constellation constellation NN cord-028721-x6f26ahr 2425 17 of of IN cord-028721-x6f26ahr 2425 18 anomalies anomaly NNS cord-028721-x6f26ahr 2425 19 that that WDT cord-028721-x6f26ahr 2425 20 most most RBS cord-028721-x6f26ahr 2425 21 frequently frequently RB cord-028721-x6f26ahr 2425 22 include include VBP cord-028721-x6f26ahr 2425 23 normal normal JJ cord-028721-x6f26ahr 2425 24 development development NN cord-028721-x6f26ahr 2425 25 of of IN cord-028721-x6f26ahr 2425 26 the the DT cord-028721-x6f26ahr 2425 27 testis testis NN cord-028721-x6f26ahr 2425 28 and and CC cord-028721-x6f26ahr 2425 29 globus globus NNP cord-028721-x6f26ahr 2425 30 major major NN cord-028721-x6f26ahr 2425 31 and and CC cord-028721-x6f26ahr 2425 32 hypoplasia hypoplasia NN cord-028721-x6f26ahr 2425 33 of of IN cord-028721-x6f26ahr 2425 34 the the DT cord-028721-x6f26ahr 2425 35 other other JJ cord-028721-x6f26ahr 2425 36 excretory excretory JJ cord-028721-x6f26ahr 2425 37 duct duct NN cord-028721-x6f26ahr 2425 38 segments segment NNS cord-028721-x6f26ahr 2425 39 , , , cord-028721-x6f26ahr 2425 40 or or CC cord-028721-x6f26ahr 2425 41 agenesis agenesis NN cord-028721-x6f26ahr 2425 42 of of IN cord-028721-x6f26ahr 2425 43 an an DT cord-028721-x6f26ahr 2425 44 excretory excretory JJ cord-028721-x6f26ahr 2425 45 duct duct NN cord-028721-x6f26ahr 2425 46 segment segment NN cord-028721-x6f26ahr 2425 47 ( ( -LRB- cord-028721-x6f26ahr 2425 48 epididymis epididymis NN cord-028721-x6f26ahr 2425 49 , , , cord-028721-x6f26ahr 2425 50 vas vas NNP cord-028721-x6f26ahr 2425 51 deferens deferen NNS cord-028721-x6f26ahr 2425 52 , , , cord-028721-x6f26ahr 2425 53 or or CC cord-028721-x6f26ahr 2425 54 seminal seminal JJ cord-028721-x6f26ahr 2425 55 vesicle vesicle NN cord-028721-x6f26ahr 2425 56 ) ) -RRB- cord-028721-x6f26ahr 2425 57 . . . cord-028721-x6f26ahr 2426 1 Epididymal Epididymal NNP cord-028721-x6f26ahr 2426 2 anomalies anomaly NNS cord-028721-x6f26ahr 2426 3 . . . cord-028721-x6f26ahr 2427 1 The the DT cord-028721-x6f26ahr 2427 2 most most RBS cord-028721-x6f26ahr 2427 3 frequent frequent JJ cord-028721-x6f26ahr 2427 4 epididymal epididymal JJ cord-028721-x6f26ahr 2427 5 anomalies anomaly NNS cord-028721-x6f26ahr 2427 6 are be VBP cord-028721-x6f26ahr 2427 7 absence absence NN cord-028721-x6f26ahr 2427 8 of of IN cord-028721-x6f26ahr 2427 9 the the DT cord-028721-x6f26ahr 2427 10 epididymis epididymis NN cord-028721-x6f26ahr 2427 11 , , , cord-028721-x6f26ahr 2427 12 testis testis NN cord-028721-x6f26ahr 2427 13 - - HYPH cord-028721-x6f26ahr 2427 14 epididymis epididymis NN cord-028721-x6f26ahr 2427 15 dissociation dissociation NN cord-028721-x6f26ahr 2427 16 , , , cord-028721-x6f26ahr 2427 17 defective defective JJ cord-028721-x6f26ahr 2427 18 connection connection NN cord-028721-x6f26ahr 2427 19 of of IN cord-028721-x6f26ahr 2427 20 the the DT cord-028721-x6f26ahr 2427 21 vas vas FW cord-028721-x6f26ahr 2427 22 deferens deferen NNS cord-028721-x6f26ahr 2427 23 and and CC cord-028721-x6f26ahr 2427 24 epididymis epididymis NN cord-028721-x6f26ahr 2427 25 , , , cord-028721-x6f26ahr 2427 26 epididymal epididymal JJ cord-028721-x6f26ahr 2427 27 cyst cyst NN cord-028721-x6f26ahr 2427 28 , , , cord-028721-x6f26ahr 2427 29 and and CC cord-028721-x6f26ahr 2427 30 anatomical anatomical JJ cord-028721-x6f26ahr 2427 31 abnormalities abnormality NNS cord-028721-x6f26ahr 2427 32 of of IN cord-028721-x6f26ahr 2427 33 the the DT cord-028721-x6f26ahr 2427 34 epididymis epididymis NN cord-028721-x6f26ahr 2427 35 . . . cord-028721-x6f26ahr 2428 1 Complete complete JJ cord-028721-x6f26ahr 2428 2 absence absence NN cord-028721-x6f26ahr 2428 3 of of IN cord-028721-x6f26ahr 2428 4 the the DT cord-028721-x6f26ahr 2428 5 epididymis epididymis NN cord-028721-x6f26ahr 2428 6 is be VBZ cord-028721-x6f26ahr 2428 7 frequent frequent JJ cord-028721-x6f26ahr 2428 8 in in IN cord-028721-x6f26ahr 2428 9 monorchidism monorchidism NN cord-028721-x6f26ahr 2428 10 and and CC cord-028721-x6f26ahr 2428 11 anorchidism anorchidism NN cord-028721-x6f26ahr 2428 12 . . . cord-028721-x6f26ahr 2429 1 The the DT cord-028721-x6f26ahr 2429 2 epididymis epididymis NN cord-028721-x6f26ahr 2429 3 is be VBZ cord-028721-x6f26ahr 2429 4 replaced replace VBN cord-028721-x6f26ahr 2429 5 by by IN cord-028721-x6f26ahr 2429 6 a a DT cord-028721-x6f26ahr 2429 7 small small JJ cord-028721-x6f26ahr 2429 8 mass mass NN cord-028721-x6f26ahr 2429 9 of of IN cord-028721-x6f26ahr 2429 10 cellular cellular JJ cord-028721-x6f26ahr 2429 11 connective connective JJ cord-028721-x6f26ahr 2429 12 tissue tissue NN cord-028721-x6f26ahr 2429 13 with with IN cord-028721-x6f26ahr 2429 14 abundant abundant JJ cord-028721-x6f26ahr 2429 15 blood blood NN cord-028721-x6f26ahr 2429 16 vessels vessel NNS cord-028721-x6f26ahr 2429 17 at at IN cord-028721-x6f26ahr 2429 18 the the DT cord-028721-x6f26ahr 2429 19 blind blind JJ cord-028721-x6f26ahr 2429 20 end end NN cord-028721-x6f26ahr 2429 21 of of IN cord-028721-x6f26ahr 2429 22 the the DT cord-028721-x6f26ahr 2429 23 vas vas FW cord-028721-x6f26ahr 2429 24 deferens deferen NNS cord-028721-x6f26ahr 2429 25 . . . cord-028721-x6f26ahr 2430 1 Partial partial JJ cord-028721-x6f26ahr 2430 2 absence absence NN cord-028721-x6f26ahr 2430 3 of of IN cord-028721-x6f26ahr 2430 4 the the DT cord-028721-x6f26ahr 2430 5 epididymis epididymis NN cord-028721-x6f26ahr 2430 6 is be VBZ cord-028721-x6f26ahr 2430 7 more more RBR cord-028721-x6f26ahr 2430 8 frequent frequent JJ cord-028721-x6f26ahr 2430 9 than than IN cord-028721-x6f26ahr 2430 10 complete complete JJ cord-028721-x6f26ahr 2430 11 absence absence NN cord-028721-x6f26ahr 2430 12 . . . cord-028721-x6f26ahr 2431 1 Absence absence NN cord-028721-x6f26ahr 2431 2 of of IN cord-028721-x6f26ahr 2431 3 the the DT cord-028721-x6f26ahr 2431 4 corpus corpus NN cord-028721-x6f26ahr 2431 5 of of IN cord-028721-x6f26ahr 2431 6 the the DT cord-028721-x6f26ahr 2431 7 epididymis epididymis NN cord-028721-x6f26ahr 2431 8 gives give VBZ cord-028721-x6f26ahr 2431 9 rise rise NN cord-028721-x6f26ahr 2431 10 to to IN cord-028721-x6f26ahr 2431 11 a a DT cord-028721-x6f26ahr 2431 12 characteristic characteristic JJ cord-028721-x6f26ahr 2431 13 malformation malformation NN cord-028721-x6f26ahr 2431 14 called call VBN cord-028721-x6f26ahr 2431 15 bilobated bilobated JJ cord-028721-x6f26ahr 2431 16 epididymis epididymis NNP cord-028721-x6f26ahr 2431 17 . . . cord-028721-x6f26ahr 2432 1 This this DT cord-028721-x6f26ahr 2432 2 varies vary VBZ cord-028721-x6f26ahr 2432 3 from from IN cord-028721-x6f26ahr 2432 4 simple simple JJ cord-028721-x6f26ahr 2432 5 strangulation strangulation NN cord-028721-x6f26ahr 2432 6 to to TO cord-028721-x6f26ahr 2432 7 complete complete JJ cord-028721-x6f26ahr 2432 8 separation separation NN cord-028721-x6f26ahr 2432 9 of of IN cord-028721-x6f26ahr 2432 10 the the DT cord-028721-x6f26ahr 2432 11 caput caput NN cord-028721-x6f26ahr 2432 12 and and CC cord-028721-x6f26ahr 2432 13 cauda cauda NN cord-028721-x6f26ahr 2432 14 . . . cord-028721-x6f26ahr 2433 1 These these DT cord-028721-x6f26ahr 2433 2 anomalies anomaly NNS cord-028721-x6f26ahr 2433 3 are be VBP cord-028721-x6f26ahr 2433 4 often often RB cord-028721-x6f26ahr 2433 5 associated associate VBN cord-028721-x6f26ahr 2433 6 with with IN cord-028721-x6f26ahr 2433 7 absence absence NN cord-028721-x6f26ahr 2433 8 of of IN cord-028721-x6f26ahr 2433 9 the the DT cord-028721-x6f26ahr 2433 10 vas vas NNP cord-028721-x6f26ahr 2433 11 deferens deferen NNS cord-028721-x6f26ahr 2433 12 . . . cord-028721-x6f26ahr 2434 1 Testis testis NN cord-028721-x6f26ahr 2434 2 - - HYPH cord-028721-x6f26ahr 2434 3 epididymis epididymis NN cord-028721-x6f26ahr 2434 4 dissociation dissociation NN cord-028721-x6f26ahr 2434 5 is be VBZ cord-028721-x6f26ahr 2434 6 found find VBN cord-028721-x6f26ahr 2434 7 in in IN cord-028721-x6f26ahr 2434 8 1 1 CD cord-028721-x6f26ahr 2434 9 % % NN cord-028721-x6f26ahr 2434 10 of of IN cord-028721-x6f26ahr 2434 11 cases case NNS cord-028721-x6f26ahr 2434 12 of of IN cord-028721-x6f26ahr 2434 13 obstructive obstructive JJ cord-028721-x6f26ahr 2434 14 azoospermia azoospermia NN cord-028721-x6f26ahr 2434 15 and and CC cord-028721-x6f26ahr 2434 16 is be VBZ cord-028721-x6f26ahr 2434 17 usually usually RB cord-028721-x6f26ahr 2434 18 associated associate VBN cord-028721-x6f26ahr 2434 19 with with IN cord-028721-x6f26ahr 2434 20 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2434 21 . . . cord-028721-x6f26ahr 2435 1 Defects defect NNS cord-028721-x6f26ahr 2435 2 in in IN cord-028721-x6f26ahr 2435 3 connection connection NN cord-028721-x6f26ahr 2435 4 between between IN cord-028721-x6f26ahr 2435 5 the the DT cord-028721-x6f26ahr 2435 6 ductuli ductuli NNP cord-028721-x6f26ahr 2435 7 efferentes efferentes NNPS cord-028721-x6f26ahr 2435 8 and and CC cord-028721-x6f26ahr 2435 9 the the DT cord-028721-x6f26ahr 2435 10 ductus ductus NN cord-028721-x6f26ahr 2435 11 epididymidis epididymidis NN cord-028721-x6f26ahr 2435 12 are be VBP cord-028721-x6f26ahr 2435 13 rarely rarely RB cord-028721-x6f26ahr 2435 14 complete complete JJ cord-028721-x6f26ahr 2435 15 . . . cord-028721-x6f26ahr 2436 1 In in IN cord-028721-x6f26ahr 2436 2 the the DT cord-028721-x6f26ahr 2436 3 incomplete incomplete JJ cord-028721-x6f26ahr 2436 4 form form NN cord-028721-x6f26ahr 2436 5 , , , cord-028721-x6f26ahr 2436 6 some some DT cord-028721-x6f26ahr 2436 7 of of IN cord-028721-x6f26ahr 2436 8 the the DT cord-028721-x6f26ahr 2436 9 fi fi NNP cord-028721-x6f26ahr 2436 10 ve ve VBD cord-028721-x6f26ahr 2436 11 to to IN cord-028721-x6f26ahr 2436 12 30 30 CD cord-028721-x6f26ahr 2436 13 ductuli ductuli NNP cord-028721-x6f26ahr 2436 14 efferentes efferente NNS cord-028721-x6f26ahr 2436 15 in in IN cord-028721-x6f26ahr 2436 16 the the DT cord-028721-x6f26ahr 2436 17 epididymis epididymis NN cord-028721-x6f26ahr 2436 18 are be VBP cord-028721-x6f26ahr 2436 19 short short JJ cord-028721-x6f26ahr 2436 20 and and CC cord-028721-x6f26ahr 2436 21 end end VB cord-028721-x6f26ahr 2436 22 blindly blindly RB cord-028721-x6f26ahr 2436 23 . . . cord-028721-x6f26ahr 2437 1 Epididymal Epididymal NNP cord-028721-x6f26ahr 2437 2 cysts cyst NNS cord-028721-x6f26ahr 2437 3 usually usually RB cord-028721-x6f26ahr 2437 4 arise arise VBP cord-028721-x6f26ahr 2437 5 from from IN cord-028721-x6f26ahr 2437 6 blind blind RB cord-028721-x6f26ahr 2437 7 - - HYPH cord-028721-x6f26ahr 2437 8 ended ended JJ cord-028721-x6f26ahr 2437 9 ductuli ductuli NNP cord-028721-x6f26ahr 2437 10 efferentes efferentes NNPS cord-028721-x6f26ahr 2437 11 and and CC cord-028721-x6f26ahr 2437 12 contain contain VBP cord-028721-x6f26ahr 2437 13 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2437 14 . . . cord-028721-x6f26ahr 2438 1 These these DT cord-028721-x6f26ahr 2438 2 spermatoceles spermatocele NNS cord-028721-x6f26ahr 2438 3 retain retain VBP cord-028721-x6f26ahr 2438 4 their -PRON- PRP$ cord-028721-x6f26ahr 2438 5 epithelial epithelial JJ cord-028721-x6f26ahr 2438 6 lining lining NN cord-028721-x6f26ahr 2438 7 , , , cord-028721-x6f26ahr 2438 8 although although IN cord-028721-x6f26ahr 2438 9 it -PRON- PRP cord-028721-x6f26ahr 2438 10 becomes become VBZ cord-028721-x6f26ahr 2438 11 atrophic atrophic JJ cord-028721-x6f26ahr 2438 12 ( ( -LRB- cord-028721-x6f26ahr 2438 13 Fig fig NN cord-028721-x6f26ahr 2438 14 . . . cord-028721-x6f26ahr 2438 15 12 12 CD cord-028721-x6f26ahr 2438 16 - - SYM cord-028721-x6f26ahr 2438 17 119 119 CD cord-028721-x6f26ahr 2438 18 ) ) -RRB- cord-028721-x6f26ahr 2438 19 . . . cord-028721-x6f26ahr 2439 1 Spermatozoa Spermatozoa NNP cord-028721-x6f26ahr 2439 2 may may MD cord-028721-x6f26ahr 2439 3 be be VB cord-028721-x6f26ahr 2439 4 obtained obtain VBN cord-028721-x6f26ahr 2439 5 from from IN cord-028721-x6f26ahr 2439 6 these these DT cord-028721-x6f26ahr 2439 7 cysts cyst NNS cord-028721-x6f26ahr 2439 8 . . . cord-028721-x6f26ahr 2440 1 Some some DT cord-028721-x6f26ahr 2440 2 epididymal epididymal JJ cord-028721-x6f26ahr 2440 3 cysts cyst NNS cord-028721-x6f26ahr 2440 4 arise arise VBP cord-028721-x6f26ahr 2440 5 from from IN cord-028721-x6f26ahr 2440 6 embryonic embryonic JJ cord-028721-x6f26ahr 2440 7 remnants remnant NNS cord-028721-x6f26ahr 2440 8 , , , cord-028721-x6f26ahr 2440 9 do do VBP cord-028721-x6f26ahr 2440 10 not not RB cord-028721-x6f26ahr 2440 11 contain contain VB cord-028721-x6f26ahr 2440 12 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 2440 13 , , , cord-028721-x6f26ahr 2440 14 and and CC cord-028721-x6f26ahr 2440 15 are be VBP cord-028721-x6f26ahr 2440 16 lined line VBN cord-028721-x6f26ahr 2440 17 by by IN cord-028721-x6f26ahr 2440 18 columnar columnar JJ cord-028721-x6f26ahr 2440 19 or or CC cord-028721-x6f26ahr 2440 20 pseudostratifi pseudostratifi NN cord-028721-x6f26ahr 2440 21 ed ed NN cord-028721-x6f26ahr 2440 22 epithelium epithelium NN cord-028721-x6f26ahr 2440 23 . . . cord-028721-x6f26ahr 2441 1 Wolffi Wolffi NNP cord-028721-x6f26ahr 2441 2 an an DT cord-028721-x6f26ahr 2441 3 cyst cyst NN cord-028721-x6f26ahr 2441 4 , , , cord-028721-x6f26ahr 2441 5 unlike unlike IN cord-028721-x6f26ahr 2441 6 müllerian müllerian JJ cord-028721-x6f26ahr 2441 7 cyst cyst NN cord-028721-x6f26ahr 2441 8 , , , cord-028721-x6f26ahr 2441 9 is be VBZ cord-028721-x6f26ahr 2441 10 immunoreactive immunoreactive JJ cord-028721-x6f26ahr 2441 11 in in IN cord-028721-x6f26ahr 2441 12 the the DT cord-028721-x6f26ahr 2441 13 apical apical JJ cord-028721-x6f26ahr 2441 14 border border NN cord-028721-x6f26ahr 2441 15 of of IN cord-028721-x6f26ahr 2441 16 epithelial epithelial JJ cord-028721-x6f26ahr 2441 17 cells cell NNS cord-028721-x6f26ahr 2441 18 with with IN cord-028721-x6f26ahr 2441 19 CD10 CD10 NNP cord-028721-x6f26ahr 2441 20 . . . cord-028721-x6f26ahr 2442 1 1051 1051 CD cord-028721-x6f26ahr 2442 2 Cyst Cyst NNP cord-028721-x6f26ahr 2442 3 lined line VBN cord-028721-x6f26ahr 2442 4 by by IN cord-028721-x6f26ahr 2442 5 clear clear JJ cord-028721-x6f26ahr 2442 6 cells cell NNS cord-028721-x6f26ahr 2442 7 with with IN cord-028721-x6f26ahr 2442 8 or or CC cord-028721-x6f26ahr 2442 9 without without IN cord-028721-x6f26ahr 2442 10 papillae papilla NNS cord-028721-x6f26ahr 2442 11 raises raise VBZ cord-028721-x6f26ahr 2442 12 concern concern NN cord-028721-x6f26ahr 2442 13 for for IN cord-028721-x6f26ahr 2442 14 von von NNP cord-028721-x6f26ahr 2442 15 Hippel Hippel NNP cord-028721-x6f26ahr 2442 16 - - HYPH cord-028721-x6f26ahr 2442 17 Lindau Lindau NNP cord-028721-x6f26ahr 2442 18 disease disease NN cord-028721-x6f26ahr 2442 19 . . . cord-028721-x6f26ahr 2443 1 1052 1052 CD cord-028721-x6f26ahr 2443 2 Large large JJ cord-028721-x6f26ahr 2443 3 epididymal epididymal JJ cord-028721-x6f26ahr 2443 4 cyst cyst NN cord-028721-x6f26ahr 2443 5 requires require VBZ cord-028721-x6f26ahr 2443 6 removal removal NN cord-028721-x6f26ahr 2443 7 and and CC cord-028721-x6f26ahr 2443 8 must must MD cord-028721-x6f26ahr 2443 9 be be VB cord-028721-x6f26ahr 2443 10 excised excise VBN cord-028721-x6f26ahr 2443 11 with with IN cord-028721-x6f26ahr 2443 12 great great JJ cord-028721-x6f26ahr 2443 13 care care NN cord-028721-x6f26ahr 2443 14 to to TO cord-028721-x6f26ahr 2443 15 avoid avoid VB cord-028721-x6f26ahr 2443 16 damaging damage VBG cord-028721-x6f26ahr 2443 17 the the DT cord-028721-x6f26ahr 2443 18 ductuli ductuli NNP cord-028721-x6f26ahr 2443 19 efferentes efferentes NNPS cord-028721-x6f26ahr 2443 20 and and CC cord-028721-x6f26ahr 2443 21 resulting result VBG cord-028721-x6f26ahr 2443 22 in in IN cord-028721-x6f26ahr 2443 23 obstruction obstruction NN cord-028721-x6f26ahr 2443 24 . . . cord-028721-x6f26ahr 2444 1 Epididymal Epididymal NNP cord-028721-x6f26ahr 2444 2 cyst cyst NN cord-028721-x6f26ahr 2444 3 is be VBZ cord-028721-x6f26ahr 2444 4 present present JJ cord-028721-x6f26ahr 2444 5 in in IN cord-028721-x6f26ahr 2444 6 about about RB cord-028721-x6f26ahr 2444 7 5 5 CD cord-028721-x6f26ahr 2444 8 % % NN cord-028721-x6f26ahr 2444 9 of of IN cord-028721-x6f26ahr 2444 10 males male NNS cord-028721-x6f26ahr 2444 11 , , , cord-028721-x6f26ahr 2444 12 and and CC cord-028721-x6f26ahr 2444 13 the the DT cord-028721-x6f26ahr 2444 14 incidence incidence NN cord-028721-x6f26ahr 2444 15 is be VBZ cord-028721-x6f26ahr 2444 16 high high JJ cord-028721-x6f26ahr 2444 17 ( ( -LRB- cord-028721-x6f26ahr 2444 18 21 21 CD cord-028721-x6f26ahr 2444 19 % % NN cord-028721-x6f26ahr 2444 20 ) ) -RRB- cord-028721-x6f26ahr 2444 21 in in IN cord-028721-x6f26ahr 2444 22 those those DT cord-028721-x6f26ahr 2444 23 exposed expose VBN cord-028721-x6f26ahr 2444 24 to to IN cord-028721-x6f26ahr 2444 25 diethylstilbestrol diethylstilbestrol NN cord-028721-x6f26ahr 2444 26 during during IN cord-028721-x6f26ahr 2444 27 gestation gestation NN cord-028721-x6f26ahr 2444 28 . . . cord-028721-x6f26ahr 2445 1 The the DT cord-028721-x6f26ahr 2445 2 incidence incidence NN cord-028721-x6f26ahr 2445 3 of of IN cord-028721-x6f26ahr 2445 4 epididymal epididymal JJ cord-028721-x6f26ahr 2445 5 cyst cyst NN cord-028721-x6f26ahr 2445 6 in in IN cord-028721-x6f26ahr 2445 7 those those DT cord-028721-x6f26ahr 2445 8 with with IN cord-028721-x6f26ahr 2445 9 hepatorenal hepatorenal NNP cord-028721-x6f26ahr 2445 10 polycystosis polycystosis NNP cord-028721-x6f26ahr 2445 11 is be VBZ cord-028721-x6f26ahr 2445 12 similar similar JJ cord-028721-x6f26ahr 2445 13 to to IN cord-028721-x6f26ahr 2445 14 that that DT cord-028721-x6f26ahr 2445 15 in in IN cord-028721-x6f26ahr 2445 16 the the DT cord-028721-x6f26ahr 2445 17 general general JJ cord-028721-x6f26ahr 2445 18 population population NN cord-028721-x6f26ahr 2445 19 . . . cord-028721-x6f26ahr 2446 1 1053 1053 CD cord-028721-x6f26ahr 2446 2 Anomalies anomaly NNS cord-028721-x6f26ahr 2446 3 in in IN cord-028721-x6f26ahr 2446 4 epididymal epididymal JJ cord-028721-x6f26ahr 2446 5 confi confi NN cord-028721-x6f26ahr 2446 6 guration guration NN cord-028721-x6f26ahr 2446 7 , , , cord-028721-x6f26ahr 2446 8 altering alter VBG cord-028721-x6f26ahr 2446 9 its -PRON- PRP$ cord-028721-x6f26ahr 2446 10 shape shape NN cord-028721-x6f26ahr 2446 11 and and CC cord-028721-x6f26ahr 2446 12 location location NN cord-028721-x6f26ahr 2446 13 , , , cord-028721-x6f26ahr 2446 14 are be VBP cord-028721-x6f26ahr 2446 15 frequent frequent JJ cord-028721-x6f26ahr 2446 16 in in IN cord-028721-x6f26ahr 2446 17 men man NNS cord-028721-x6f26ahr 2446 18 with with IN cord-028721-x6f26ahr 2446 19 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2446 20 and and CC cord-028721-x6f26ahr 2446 21 uncommon uncommon JJ cord-028721-x6f26ahr 2446 22 with with IN cord-028721-x6f26ahr 2446 23 descended descended JJ cord-028721-x6f26ahr 2446 24 testes testis NNS cord-028721-x6f26ahr 2446 25 . . . cord-028721-x6f26ahr 2447 1 The the DT cord-028721-x6f26ahr 2447 2 most most RBS cord-028721-x6f26ahr 2447 3 common common JJ cord-028721-x6f26ahr 2447 4 malformations malformation NNS cord-028721-x6f26ahr 2447 5 are be VBP cord-028721-x6f26ahr 2447 6 elongated elongated JJ cord-028721-x6f26ahr 2447 7 epididymis epididymis NN cord-028721-x6f26ahr 2447 8 , , , cord-028721-x6f26ahr 2447 9 angulated angulated JJ cord-028721-x6f26ahr 2447 10 epididymis epididymis NN cord-028721-x6f26ahr 2447 11 , , , cord-028721-x6f26ahr 2447 12 and and CC cord-028721-x6f26ahr 2447 13 free free JJ cord-028721-x6f26ahr 2447 14 epididymis epididymis NN cord-028721-x6f26ahr 2447 15 . . . cord-028721-x6f26ahr 2448 1 Elongated elongated JJ cord-028721-x6f26ahr 2448 2 epididymis epididymis NN cord-028721-x6f26ahr 2448 3 is be VBZ cord-028721-x6f26ahr 2448 4 found find VBN cord-028721-x6f26ahr 2448 5 in in IN cord-028721-x6f26ahr 2448 6 approximately approximately RB cord-028721-x6f26ahr 2448 7 68 68 CD cord-028721-x6f26ahr 2448 8 % % NN cord-028721-x6f26ahr 2448 9 of of IN cord-028721-x6f26ahr 2448 10 undescended undescended JJ cord-028721-x6f26ahr 2448 11 testes testis NNS cord-028721-x6f26ahr 2448 12 . . . cord-028721-x6f26ahr 2449 1 The the DT cord-028721-x6f26ahr 2449 2 length length NN cord-028721-x6f26ahr 2449 3 of of IN cord-028721-x6f26ahr 2449 4 the the DT cord-028721-x6f26ahr 2449 5 epididymis epididymis NN cord-028721-x6f26ahr 2449 6 may may MD cord-028721-x6f26ahr 2449 7 be be VB cord-028721-x6f26ahr 2449 8 several several JJ cord-028721-x6f26ahr 2449 9 times time NNS cord-028721-x6f26ahr 2449 10 that that DT cord-028721-x6f26ahr 2449 11 of of IN cord-028721-x6f26ahr 2449 12 the the DT cord-028721-x6f26ahr 2449 13 testis testis NN cord-028721-x6f26ahr 2449 14 , , , cord-028721-x6f26ahr 2449 15 and and CC cord-028721-x6f26ahr 2449 16 , , , cord-028721-x6f26ahr 2449 17 in in IN cord-028721-x6f26ahr 2449 18 abdominal abdominal JJ cord-028721-x6f26ahr 2449 19 or or CC cord-028721-x6f26ahr 2449 20 inguinal inguinal JJ cord-028721-x6f26ahr 2449 21 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2449 22 , , , cord-028721-x6f26ahr 2449 23 the the DT cord-028721-x6f26ahr 2449 24 epididymis epididymis NN cord-028721-x6f26ahr 2449 25 extends extend VBZ cord-028721-x6f26ahr 2449 26 several several JJ cord-028721-x6f26ahr 2449 27 centimeters centimeter NNS cord-028721-x6f26ahr 2449 28 below below IN cord-028721-x6f26ahr 2449 29 the the DT cord-028721-x6f26ahr 2449 30 testis testis NN cord-028721-x6f26ahr 2449 31 . . . cord-028721-x6f26ahr 2450 1 Angulated Angulated NNP cord-028721-x6f26ahr 2450 2 epididymis epididymis NN cord-028721-x6f26ahr 2450 3 is be VBZ cord-028721-x6f26ahr 2450 4 characterized characterize VBN cord-028721-x6f26ahr 2450 5 by by IN cord-028721-x6f26ahr 2450 6 a a DT cord-028721-x6f26ahr 2450 7 long long JJ cord-028721-x6f26ahr 2450 8 epididymis epididymis NN cord-028721-x6f26ahr 2450 9 that that WDT cord-028721-x6f26ahr 2450 10 has have VBZ cord-028721-x6f26ahr 2450 11 a a DT cord-028721-x6f26ahr 2450 12 sharp sharp JJ cord-028721-x6f26ahr 2450 13 bend bend NN cord-028721-x6f26ahr 2450 14 in in IN cord-028721-x6f26ahr 2450 15 the the DT cord-028721-x6f26ahr 2450 16 corpus corpus NN cord-028721-x6f26ahr 2450 17 with with IN cord-028721-x6f26ahr 2450 18 or or CC cord-028721-x6f26ahr 2450 19 without without IN cord-028721-x6f26ahr 2450 20 stenosis stenosis NN cord-028721-x6f26ahr 2450 21 . . . cord-028721-x6f26ahr 2451 1 With with IN cord-028721-x6f26ahr 2451 2 free free JJ cord-028721-x6f26ahr 2451 3 epididymis epididymis NN cord-028721-x6f26ahr 2451 4 , , , cord-028721-x6f26ahr 2451 5 all all DT cord-028721-x6f26ahr 2451 6 or or CC cord-028721-x6f26ahr 2451 7 part part NN cord-028721-x6f26ahr 2451 8 of of IN cord-028721-x6f26ahr 2451 9 the the DT cord-028721-x6f26ahr 2451 10 epididymis epididymis NN cord-028721-x6f26ahr 2451 11 is be VBZ cord-028721-x6f26ahr 2451 12 unattached unattached JJ cord-028721-x6f26ahr 2451 13 to to IN cord-028721-x6f26ahr 2451 14 the the DT cord-028721-x6f26ahr 2451 15 testis testis NN cord-028721-x6f26ahr 2451 16 . . . cord-028721-x6f26ahr 2452 1 The the DT cord-028721-x6f26ahr 2452 2 most most RBS cord-028721-x6f26ahr 2452 3 common common JJ cord-028721-x6f26ahr 2452 4 variant variant NN cord-028721-x6f26ahr 2452 5 is be VBZ cord-028721-x6f26ahr 2452 6 epididymis epididymis NN cord-028721-x6f26ahr 2452 7 with with IN cord-028721-x6f26ahr 2452 8 free free JJ cord-028721-x6f26ahr 2452 9 cauda cauda NN cord-028721-x6f26ahr 2452 10 . . . cord-028721-x6f26ahr 2453 1 Vas Vas NNP cord-028721-x6f26ahr 2453 2 deferens deferens NN cord-028721-x6f26ahr 2453 3 anomalies anomaly NNS cord-028721-x6f26ahr 2453 4 . . . cord-028721-x6f26ahr 2454 1 The the DT cord-028721-x6f26ahr 2454 2 most most RBS cord-028721-x6f26ahr 2454 3 frequent frequent JJ cord-028721-x6f26ahr 2454 4 anomalies anomaly NNS cord-028721-x6f26ahr 2454 5 are be VBP cord-028721-x6f26ahr 2454 6 of of IN cord-028721-x6f26ahr 2454 7 the the DT cord-028721-x6f26ahr 2454 8 vas vas NNP cord-028721-x6f26ahr 2454 9 deferens deferen NNS cord-028721-x6f26ahr 2454 10 are be VBP cord-028721-x6f26ahr 2454 11 congenital congenital JJ cord-028721-x6f26ahr 2454 12 absence absence NN cord-028721-x6f26ahr 2454 13 , , , cord-028721-x6f26ahr 2454 14 segmental segmental JJ cord-028721-x6f26ahr 2454 15 aplasia aplasia NNP cord-028721-x6f26ahr 2454 16 , , , cord-028721-x6f26ahr 2454 17 ectopia ectopia NN cord-028721-x6f26ahr 2454 18 , , , cord-028721-x6f26ahr 2454 19 duplication duplication NN cord-028721-x6f26ahr 2454 20 , , , cord-028721-x6f26ahr 2454 21 diverticula diverticula NN cord-028721-x6f26ahr 2454 22 , , , cord-028721-x6f26ahr 2454 23 and and CC cord-028721-x6f26ahr 2454 24 crossed cross VBD cord-028721-x6f26ahr 2454 25 dystopia dystopia NN cord-028721-x6f26ahr 2454 26 . . . cord-028721-x6f26ahr 2455 1 1054 1054 CD cord-028721-x6f26ahr 2455 2 Congenital congenital JJ cord-028721-x6f26ahr 2455 3 absence absence NN cord-028721-x6f26ahr 2455 4 is be VBZ cord-028721-x6f26ahr 2455 5 defi defi NNP cord-028721-x6f26ahr 2455 6 ned ned NNP cord-028721-x6f26ahr 2455 7 as as IN cord-028721-x6f26ahr 2455 8 unilateral unilateral JJ cord-028721-x6f26ahr 2455 9 or or CC cord-028721-x6f26ahr 2455 10 bilateral bilateral JJ cord-028721-x6f26ahr 2455 11 absence absence NN cord-028721-x6f26ahr 2455 12 of of IN cord-028721-x6f26ahr 2455 13 either either CC cord-028721-x6f26ahr 2455 14 the the DT cord-028721-x6f26ahr 2455 15 whole whole JJ cord-028721-x6f26ahr 2455 16 vas vas NNP cord-028721-x6f26ahr 2455 17 deferens deferen NNS cord-028721-x6f26ahr 2455 18 or or CC cord-028721-x6f26ahr 2455 19 only only RB cord-028721-x6f26ahr 2455 20 a a DT cord-028721-x6f26ahr 2455 21 segment segment NN cord-028721-x6f26ahr 2455 22 . . . cord-028721-x6f26ahr 2456 1 Obviously obviously RB cord-028721-x6f26ahr 2456 2 , , , cord-028721-x6f26ahr 2456 3 azoospermia azoospermia NN cord-028721-x6f26ahr 2456 4 occurs occur VBZ cord-028721-x6f26ahr 2456 5 with with IN cord-028721-x6f26ahr 2456 6 bilateral bilateral JJ cord-028721-x6f26ahr 2456 7 absence absence NN cord-028721-x6f26ahr 2456 8 . . . cord-028721-x6f26ahr 2457 1 The the DT cord-028721-x6f26ahr 2457 2 frequency frequency NN cord-028721-x6f26ahr 2457 3 of of IN cord-028721-x6f26ahr 2457 4 this this DT cord-028721-x6f26ahr 2457 5 malformation malformation NN cord-028721-x6f26ahr 2457 6 varies vary VBZ cord-028721-x6f26ahr 2457 7 among among IN cord-028721-x6f26ahr 2457 8 populations population NNS cord-028721-x6f26ahr 2457 9 . . . cord-028721-x6f26ahr 2458 1 At at IN cord-028721-x6f26ahr 2458 2 autopsy autopsy NN cord-028721-x6f26ahr 2458 3 , , , cord-028721-x6f26ahr 2458 4 the the DT cord-028721-x6f26ahr 2458 5 prevalence prevalence NN cord-028721-x6f26ahr 2458 6 is be VBZ cord-028721-x6f26ahr 2458 7 0.5 0.5 CD cord-028721-x6f26ahr 2458 8 % % NN cord-028721-x6f26ahr 2458 9 , , , cord-028721-x6f26ahr 2458 10 but but CC cord-028721-x6f26ahr 2458 11 the the DT cord-028721-x6f26ahr 2458 12 clinical clinical JJ cord-028721-x6f26ahr 2458 13 incidence incidence NN cord-028721-x6f26ahr 2458 14 Infertility Infertility NNP cord-028721-x6f26ahr 2458 15 is be VBZ cord-028721-x6f26ahr 2458 16 1 1 CD cord-028721-x6f26ahr 2458 17 - - SYM cord-028721-x6f26ahr 2458 18 1.3 1.3 CD cord-028721-x6f26ahr 2458 19 % % NN cord-028721-x6f26ahr 2458 20 in in IN cord-028721-x6f26ahr 2458 21 infertile infertile JJ cord-028721-x6f26ahr 2458 22 men man NNS cord-028721-x6f26ahr 2458 23 1055 1055 CD cord-028721-x6f26ahr 2458 24 and and CC cord-028721-x6f26ahr 2458 25 10 10 CD cord-028721-x6f26ahr 2458 26 - - SYM cord-028721-x6f26ahr 2458 27 25 25 CD cord-028721-x6f26ahr 2458 28 % % NN cord-028721-x6f26ahr 2458 29 in in IN cord-028721-x6f26ahr 2458 30 patients patient NNS cord-028721-x6f26ahr 2458 31 with with IN cord-028721-x6f26ahr 2458 32 obstructive obstructive JJ cord-028721-x6f26ahr 2458 33 azoospermia azoospermia NN cord-028721-x6f26ahr 2458 34 . . . cord-028721-x6f26ahr 2459 1 Unilateral unilateral JJ cord-028721-x6f26ahr 2459 2 complete complete JJ cord-028721-x6f26ahr 2459 3 absence absence NN cord-028721-x6f26ahr 2459 4 is be VBZ cord-028721-x6f26ahr 2459 5 three three CD cord-028721-x6f26ahr 2459 6 times time NNS cord-028721-x6f26ahr 2459 7 more more RBR cord-028721-x6f26ahr 2459 8 frequent frequent JJ cord-028721-x6f26ahr 2459 9 than than IN cord-028721-x6f26ahr 2459 10 bilateral bilateral JJ cord-028721-x6f26ahr 2459 11 absence absence NN cord-028721-x6f26ahr 2459 12 , , , cord-028721-x6f26ahr 2459 13 and and CC cord-028721-x6f26ahr 2459 14 absence absence NN cord-028721-x6f26ahr 2459 15 of of IN cord-028721-x6f26ahr 2459 16 only only RB cord-028721-x6f26ahr 2459 17 a a DT cord-028721-x6f26ahr 2459 18 segment segment NN cord-028721-x6f26ahr 2459 19 is be VBZ cord-028721-x6f26ahr 2459 20 even even RB cord-028721-x6f26ahr 2459 21 more more RBR cord-028721-x6f26ahr 2459 22 frequent frequent JJ cord-028721-x6f26ahr 2459 23 . . . cord-028721-x6f26ahr 2460 1 The the DT cord-028721-x6f26ahr 2460 2 affected affected JJ cord-028721-x6f26ahr 2460 3 segment segment NN cord-028721-x6f26ahr 2460 4 may may MD cord-028721-x6f26ahr 2460 5 be be VB cord-028721-x6f26ahr 2460 6 absent absent JJ cord-028721-x6f26ahr 2460 7 or or CC cord-028721-x6f26ahr 2460 8 reduced reduce VBN cord-028721-x6f26ahr 2460 9 to to IN cord-028721-x6f26ahr 2460 10 a a DT cord-028721-x6f26ahr 2460 11 fi fi NN cord-028721-x6f26ahr 2460 12 brous brous JJ cord-028721-x6f26ahr 2460 13 cord cord NN cord-028721-x6f26ahr 2460 14 . . . cord-028721-x6f26ahr 2461 1 Absence absence NN cord-028721-x6f26ahr 2461 2 of of IN cord-028721-x6f26ahr 2461 3 the the DT cord-028721-x6f26ahr 2461 4 vas vas FW cord-028721-x6f26ahr 2461 5 deferens deferen NNS cord-028721-x6f26ahr 2461 6 may may MD cord-028721-x6f26ahr 2461 7 be be VB cord-028721-x6f26ahr 2461 8 associated associate VBN cord-028721-x6f26ahr 2461 9 with with IN cord-028721-x6f26ahr 2461 10 other other JJ cord-028721-x6f26ahr 2461 11 malformations malformation NNS cord-028721-x6f26ahr 2461 12 of of IN cord-028721-x6f26ahr 2461 13 the the DT cord-028721-x6f26ahr 2461 14 sperm sperm NN cord-028721-x6f26ahr 2461 15 excretory excretory JJ cord-028721-x6f26ahr 2461 16 ducts duct NNS cord-028721-x6f26ahr 2461 17 or or CC cord-028721-x6f26ahr 2461 18 urinary urinary JJ cord-028721-x6f26ahr 2461 19 system system NN cord-028721-x6f26ahr 2461 20 . . . cord-028721-x6f26ahr 2462 1 The the DT cord-028721-x6f26ahr 2462 2 most most RBS cord-028721-x6f26ahr 2462 3 frequent frequent JJ cord-028721-x6f26ahr 2462 4 malformations malformation NNS cord-028721-x6f26ahr 2462 5 of of IN cord-028721-x6f26ahr 2462 6 the the DT cord-028721-x6f26ahr 2462 7 excretory excretory JJ cord-028721-x6f26ahr 2462 8 ducts duct NNS cord-028721-x6f26ahr 2462 9 are be VBP cord-028721-x6f26ahr 2462 10 absence absence NN cord-028721-x6f26ahr 2462 11 of of IN cord-028721-x6f26ahr 2462 12 the the DT cord-028721-x6f26ahr 2462 13 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2462 14 ducts duct NNS cord-028721-x6f26ahr 2462 15 ( ( -LRB- cord-028721-x6f26ahr 2462 16 33 33 CD cord-028721-x6f26ahr 2462 17 % % NN cord-028721-x6f26ahr 2462 18 of of IN cord-028721-x6f26ahr 2462 19 cases case NNS cord-028721-x6f26ahr 2462 20 ) ) -RRB- cord-028721-x6f26ahr 2462 21 and and CC cord-028721-x6f26ahr 2462 22 , , , cord-028721-x6f26ahr 2462 23 less less RBR cord-028721-x6f26ahr 2462 24 frequently frequently RB cord-028721-x6f26ahr 2462 25 , , , cord-028721-x6f26ahr 2462 26 absence absence NN cord-028721-x6f26ahr 2462 27 of of IN cord-028721-x6f26ahr 2462 28 the the DT cord-028721-x6f26ahr 2462 29 seminal seminal JJ cord-028721-x6f26ahr 2462 30 vesicles vesicle NNS cord-028721-x6f26ahr 2462 31 . . . cord-028721-x6f26ahr 2463 1 About about RB cord-028721-x6f26ahr 2463 2 71 71 CD cord-028721-x6f26ahr 2463 3 % % NN cord-028721-x6f26ahr 2463 4 of of IN cord-028721-x6f26ahr 2463 5 patients patient NNS cord-028721-x6f26ahr 2463 6 with with IN cord-028721-x6f26ahr 2463 7 bilateral bilateral JJ cord-028721-x6f26ahr 2463 8 absence absence NN cord-028721-x6f26ahr 2463 9 of of IN cord-028721-x6f26ahr 2463 10 the the DT cord-028721-x6f26ahr 2463 11 vas vas NNP cord-028721-x6f26ahr 2463 12 deferens deferen NNS cord-028721-x6f26ahr 2463 13 have have VBP cord-028721-x6f26ahr 2463 14 partial partial JJ cord-028721-x6f26ahr 2463 15 aplasia aplasia NNS cord-028721-x6f26ahr 2463 16 of of IN cord-028721-x6f26ahr 2463 17 the the DT cord-028721-x6f26ahr 2463 18 epididymis epididymis NN cord-028721-x6f26ahr 2463 19 . . . cord-028721-x6f26ahr 2464 1 The the DT cord-028721-x6f26ahr 2464 2 most most RBS cord-028721-x6f26ahr 2464 3 frequent frequent JJ cord-028721-x6f26ahr 2464 4 malformations malformation NNS cord-028721-x6f26ahr 2464 5 of of IN cord-028721-x6f26ahr 2464 6 the the DT cord-028721-x6f26ahr 2464 7 urinary urinary JJ cord-028721-x6f26ahr 2464 8 system system NN cord-028721-x6f26ahr 2464 9 are be VBP cord-028721-x6f26ahr 2464 10 absence absence NN cord-028721-x6f26ahr 2464 11 of of IN cord-028721-x6f26ahr 2464 12 the the DT cord-028721-x6f26ahr 2464 13 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2464 14 kidney kidney NN cord-028721-x6f26ahr 2464 15 and and CC cord-028721-x6f26ahr 2464 16 other other JJ cord-028721-x6f26ahr 2464 17 renal renal JJ cord-028721-x6f26ahr 2464 18 anomalies anomaly NNS cord-028721-x6f26ahr 2464 19 . . . cord-028721-x6f26ahr 2465 1 Complete complete JJ cord-028721-x6f26ahr 2465 2 or or CC cord-028721-x6f26ahr 2465 3 partial partial JJ cord-028721-x6f26ahr 2465 4 absence absence NN cord-028721-x6f26ahr 2465 5 of of IN cord-028721-x6f26ahr 2465 6 the the DT cord-028721-x6f26ahr 2465 7 vas vas NNP cord-028721-x6f26ahr 2465 8 deferens deferens NN cord-028721-x6f26ahr 2465 9 occurs occur VBZ cord-028721-x6f26ahr 2465 10 frequently frequently RB cord-028721-x6f26ahr 2465 11 in in IN cord-028721-x6f26ahr 2465 12 patients patient NNS cord-028721-x6f26ahr 2465 13 with with IN cord-028721-x6f26ahr 2465 14 cystic cystic NN cord-028721-x6f26ahr 2465 15 fi fi NN cord-028721-x6f26ahr 2465 16 brosis brosis NN cord-028721-x6f26ahr 2465 17 . . . cord-028721-x6f26ahr 2466 1 Persistent persistent JJ cord-028721-x6f26ahr 2466 2 mesonephric mesonephric JJ cord-028721-x6f26ahr 2466 3 duct duct NN cord-028721-x6f26ahr 2466 4 consists consist VBZ cord-028721-x6f26ahr 2466 5 of of IN cord-028721-x6f26ahr 2466 6 the the DT cord-028721-x6f26ahr 2466 7 ureter ureter NN cord-028721-x6f26ahr 2466 8 joined join VBD cord-028721-x6f26ahr 2466 9 to to IN cord-028721-x6f26ahr 2466 10 the the DT cord-028721-x6f26ahr 2466 11 vas vas NNP cord-028721-x6f26ahr 2466 12 deferens deferens NNP cord-028721-x6f26ahr 2466 13 , , , cord-028721-x6f26ahr 2466 14 forming form VBG cord-028721-x6f26ahr 2466 15 a a DT cord-028721-x6f26ahr 2466 16 single single JJ cord-028721-x6f26ahr 2466 17 duct duct NN cord-028721-x6f26ahr 2466 18 that that WDT cord-028721-x6f26ahr 2466 19 opens open VBZ cord-028721-x6f26ahr 2466 20 in in IN cord-028721-x6f26ahr 2466 21 an an DT cord-028721-x6f26ahr 2466 22 ectopic ectopic JJ cord-028721-x6f26ahr 2466 23 orifi orifi FW cord-028721-x6f26ahr 2466 24 ce ce NN cord-028721-x6f26ahr 2466 25 between between IN cord-028721-x6f26ahr 2466 26 the the DT cord-028721-x6f26ahr 2466 27 trigone trigone NN cord-028721-x6f26ahr 2466 28 and and CC cord-028721-x6f26ahr 2466 29 the the DT cord-028721-x6f26ahr 2466 30 verumontanum verumontanum NN cord-028721-x6f26ahr 2466 31 . . . cord-028721-x6f26ahr 2467 1 This this DT cord-028721-x6f26ahr 2467 2 malformation malformation NN cord-028721-x6f26ahr 2467 3 may may MD cord-028721-x6f26ahr 2467 4 be be VB cord-028721-x6f26ahr 2467 5 associated associate VBN cord-028721-x6f26ahr 2467 6 with with IN cord-028721-x6f26ahr 2467 7 cystic cystic JJ cord-028721-x6f26ahr 2467 8 transformation transformation NN cord-028721-x6f26ahr 2467 9 or or CC cord-028721-x6f26ahr 2467 10 absence absence NN cord-028721-x6f26ahr 2467 11 of of IN cord-028721-x6f26ahr 2467 12 the the DT cord-028721-x6f26ahr 2467 13 seminal seminal JJ cord-028721-x6f26ahr 2467 14 vesicle vesicle NN cord-028721-x6f26ahr 2467 15 . . . cord-028721-x6f26ahr 2468 1 The the DT cord-028721-x6f26ahr 2468 2 kidney kidney NN cord-028721-x6f26ahr 2468 3 may may MD cord-028721-x6f26ahr 2468 4 be be VB cord-028721-x6f26ahr 2468 5 normal normal JJ cord-028721-x6f26ahr 2468 6 or or CC cord-028721-x6f26ahr 2468 7 dysplastic dysplastic JJ cord-028721-x6f26ahr 2468 8 . . . cord-028721-x6f26ahr 2469 1 Anomalies anomaly NNS cord-028721-x6f26ahr 2469 2 of of IN cord-028721-x6f26ahr 2469 3 seminal seminal JJ cord-028721-x6f26ahr 2469 4 vesicle vesicle NN cord-028721-x6f26ahr 2469 5 and and CC cord-028721-x6f26ahr 2469 6 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2469 7 duct duct NN cord-028721-x6f26ahr 2469 8 . . . cord-028721-x6f26ahr 2470 1 The the DT cord-028721-x6f26ahr 2470 2 most most RBS cord-028721-x6f26ahr 2470 3 frequent frequent JJ cord-028721-x6f26ahr 2470 4 anomalies anomaly NNS cord-028721-x6f26ahr 2470 5 are be VBP cord-028721-x6f26ahr 2470 6 agenesis agenesis NN cord-028721-x6f26ahr 2470 7 of of IN cord-028721-x6f26ahr 2470 8 the the DT cord-028721-x6f26ahr 2470 9 seminal seminal JJ cord-028721-x6f26ahr 2470 10 vesicles vesicle NNS cord-028721-x6f26ahr 2470 11 or or CC cord-028721-x6f26ahr 2470 12 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2470 13 ducts duct NNS cord-028721-x6f26ahr 2470 14 , , , cord-028721-x6f26ahr 2470 15 cyst cyst NN cord-028721-x6f26ahr 2470 16 of of IN cord-028721-x6f26ahr 2470 17 the the DT cord-028721-x6f26ahr 2470 18 seminal seminal JJ cord-028721-x6f26ahr 2470 19 vesicle vesicle NN cord-028721-x6f26ahr 2470 20 , , , cord-028721-x6f26ahr 2470 21 and and CC cord-028721-x6f26ahr 2470 22 ectopic ectopic JJ cord-028721-x6f26ahr 2470 23 opening opening NN cord-028721-x6f26ahr 2470 24 of of IN cord-028721-x6f26ahr 2470 25 the the DT cord-028721-x6f26ahr 2470 26 ureter ureter NN cord-028721-x6f26ahr 2470 27 into into IN cord-028721-x6f26ahr 2470 28 the the DT cord-028721-x6f26ahr 2470 29 seminal seminal JJ cord-028721-x6f26ahr 2470 30 vesicle vesicle NN cord-028721-x6f26ahr 2470 31 . . . cord-028721-x6f26ahr 2471 1 The the DT cord-028721-x6f26ahr 2471 2 last last JJ cord-028721-x6f26ahr 2471 3 is be VBZ cord-028721-x6f26ahr 2471 4 the the DT cord-028721-x6f26ahr 2471 5 most most RBS cord-028721-x6f26ahr 2471 6 common common JJ cord-028721-x6f26ahr 2471 7 and and CC cord-028721-x6f26ahr 2471 8 often often RB cord-028721-x6f26ahr 2471 9 is be VBZ cord-028721-x6f26ahr 2471 10 associated associate VBN cord-028721-x6f26ahr 2471 11 with with IN cord-028721-x6f26ahr 2471 12 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 2471 13 renal renal JJ cord-028721-x6f26ahr 2471 14 dysplasia dysplasia NN cord-028721-x6f26ahr 2471 15 . . . cord-028721-x6f26ahr 2472 1 Acquired acquire VBN cord-028721-x6f26ahr 2472 2 azoospermia azoospermia NN cord-028721-x6f26ahr 2473 1 Infl Infl NNP cord-028721-x6f26ahr 2473 2 ammation ammation NN cord-028721-x6f26ahr 2473 3 and and CC cord-028721-x6f26ahr 2473 4 trauma trauma NN cord-028721-x6f26ahr 2473 5 are be VBP cord-028721-x6f26ahr 2473 6 the the DT cord-028721-x6f26ahr 2473 7 main main JJ cord-028721-x6f26ahr 2473 8 causes cause NNS cord-028721-x6f26ahr 2473 9 of of IN cord-028721-x6f26ahr 2473 10 acquired acquire VBN cord-028721-x6f26ahr 2473 11 azoospermia azoospermia NN cord-028721-x6f26ahr 2473 12 . . . cord-028721-x6f26ahr 2474 1 Epididymitis epididymitis NN cord-028721-x6f26ahr 2474 2 is be VBZ cord-028721-x6f26ahr 2474 3 a a DT cord-028721-x6f26ahr 2474 4 frequent frequent JJ cord-028721-x6f26ahr 2474 5 cause cause NN cord-028721-x6f26ahr 2474 6 ; ; : cord-028721-x6f26ahr 2474 7 Chlamydia Chlamydia NNP cord-028721-x6f26ahr 2474 8 trachomatis trachomatis NN cord-028721-x6f26ahr 2474 9 1056 1056 CD cord-028721-x6f26ahr 2474 10 , , , cord-028721-x6f26ahr 2474 11 1057 1057 CD cord-028721-x6f26ahr 2474 12 and and CC cord-028721-x6f26ahr 2474 13 Escherichia Escherichia NNP cord-028721-x6f26ahr 2474 14 coli coli NNS cord-028721-x6f26ahr 2474 15 are be VBP cord-028721-x6f26ahr 2474 16 the the DT cord-028721-x6f26ahr 2474 17 most most RBS cord-028721-x6f26ahr 2474 18 common common JJ cord-028721-x6f26ahr 2474 19 infectious infectious JJ cord-028721-x6f26ahr 2474 20 causes cause NNS cord-028721-x6f26ahr 2474 21 in in IN cord-028721-x6f26ahr 2474 22 developed develop VBN cord-028721-x6f26ahr 2474 23 countries country NNS cord-028721-x6f26ahr 2474 24 . . . cord-028721-x6f26ahr 2475 1 1958 1958 CD cord-028721-x6f26ahr 2475 2 Infections infection NNS cord-028721-x6f26ahr 2475 3 with with IN cord-028721-x6f26ahr 2475 4 Neisseria Neisseria NNP cord-028721-x6f26ahr 2475 5 gonorrheae gonorrheae NN cord-028721-x6f26ahr 2475 6 and and CC cord-028721-x6f26ahr 2475 7 mycobacteria mycobacterium NNS cord-028721-x6f26ahr 2475 8 are be VBP cord-028721-x6f26ahr 2475 9 also also RB cord-028721-x6f26ahr 2475 10 implicated implicate VBN cord-028721-x6f26ahr 2475 11 , , , cord-028721-x6f26ahr 2475 12 and and CC cord-028721-x6f26ahr 2475 13 non non JJ cord-028721-x6f26ahr 2475 14 - - JJ cord-028721-x6f26ahr 2475 15 specifi specifi JJ cord-028721-x6f26ahr 2475 16 c c NN cord-028721-x6f26ahr 2475 17 epididymitis epididymitis NN cord-028721-x6f26ahr 2475 18 is be VBZ cord-028721-x6f26ahr 2475 19 important important JJ cord-028721-x6f26ahr 2475 20 . . . cord-028721-x6f26ahr 2476 1 1059 1059 CD cord-028721-x6f26ahr 2477 1 Apart apart RB cord-028721-x6f26ahr 2477 2 from from IN cord-028721-x6f26ahr 2477 3 elective elective JJ cord-028721-x6f26ahr 2477 4 vasectomy vasectomy NN cord-028721-x6f26ahr 2477 5 , , , cord-028721-x6f26ahr 2477 6 the the DT cord-028721-x6f26ahr 2477 7 most most RBS cord-028721-x6f26ahr 2477 8 frequent frequent JJ cord-028721-x6f26ahr 2477 9 traumatic traumatic JJ cord-028721-x6f26ahr 2477 10 causes cause NNS cord-028721-x6f26ahr 2477 11 of of IN cord-028721-x6f26ahr 2477 12 azoospermia azoospermia NN cord-028721-x6f26ahr 2477 13 are be VBP cord-028721-x6f26ahr 2477 14 surgical surgical JJ cord-028721-x6f26ahr 2477 15 accidents accident NNS cord-028721-x6f26ahr 2477 16 during during IN cord-028721-x6f26ahr 2477 17 herniorrhaphy herniorrhaphy NNP cord-028721-x6f26ahr 2477 18 in in IN cord-028721-x6f26ahr 2477 19 chidren chidren NNP cord-028721-x6f26ahr 2477 20 , , , cord-028721-x6f26ahr 2477 21 1060 1060 CD cord-028721-x6f26ahr 2477 22 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 2477 23 , , , cord-028721-x6f26ahr 2477 24 varicocelectomy varicocelectomy NNP cord-028721-x6f26ahr 2477 25 , , , cord-028721-x6f26ahr 2477 26 hydrocelectomy hydrocelectomy NNP cord-028721-x6f26ahr 2477 27 , , , cord-028721-x6f26ahr 2477 28 deferentography deferentography NN cord-028721-x6f26ahr 2477 29 , , , cord-028721-x6f26ahr 2477 30 1061 1061 CD cord-028721-x6f26ahr 2477 31 and and CC cord-028721-x6f26ahr 2477 32 removal removal NN cord-028721-x6f26ahr 2477 33 of of IN cord-028721-x6f26ahr 2477 34 epididymal epididymal JJ cord-028721-x6f26ahr 2477 35 cyst cyst NN cord-028721-x6f26ahr 2477 36 . . . cord-028721-x6f26ahr 2478 1 Obstructive obstructive JJ cord-028721-x6f26ahr 2478 2 azoospermia azoospermia NN cord-028721-x6f26ahr 2478 3 may may MD cord-028721-x6f26ahr 2478 4 also also RB cord-028721-x6f26ahr 2478 5 result result VB cord-028721-x6f26ahr 2478 6 from from IN cord-028721-x6f26ahr 2478 7 blockage blockage NN cord-028721-x6f26ahr 2478 8 of of IN cord-028721-x6f26ahr 2478 9 the the DT cord-028721-x6f26ahr 2478 10 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2478 11 ducts duct NNS cord-028721-x6f26ahr 2478 12 following follow VBG cord-028721-x6f26ahr 2478 13 transurethral transurethral NN cord-028721-x6f26ahr 2478 14 resection resection NN cord-028721-x6f26ahr 2478 15 , , , cord-028721-x6f26ahr 2478 16 or or CC cord-028721-x6f26ahr 2478 17 as as IN cord-028721-x6f26ahr 2478 18 a a DT cord-028721-x6f26ahr 2478 19 result result NN cord-028721-x6f26ahr 2478 20 of of IN cord-028721-x6f26ahr 2478 21 chronic chronic JJ cord-028721-x6f26ahr 2478 22 urethral urethral JJ cord-028721-x6f26ahr 2478 23 catheterization catheterization NN cord-028721-x6f26ahr 2478 24 . . . cord-028721-x6f26ahr 2479 1 Lesions lesion NNS cord-028721-x6f26ahr 2479 2 of of IN cord-028721-x6f26ahr 2479 3 the the DT cord-028721-x6f26ahr 2479 4 testis testis NN cord-028721-x6f26ahr 2479 5 and and CC cord-028721-x6f26ahr 2479 6 epididymis epididymis NN cord-028721-x6f26ahr 2479 7 may may MD cord-028721-x6f26ahr 2479 8 result result VB cord-028721-x6f26ahr 2479 9 from from IN cord-028721-x6f26ahr 2479 10 obstructed obstruct VBN cord-028721-x6f26ahr 2479 11 sperm sperm NN cord-028721-x6f26ahr 2479 12 excretory excretory JJ cord-028721-x6f26ahr 2479 13 ducts duct NNS cord-028721-x6f26ahr 2479 14 , , , cord-028721-x6f26ahr 2479 15 depending depend VBG cord-028721-x6f26ahr 2479 16 on on IN cord-028721-x6f26ahr 2479 17 the the DT cord-028721-x6f26ahr 2479 18 location location NN cord-028721-x6f26ahr 2479 19 , , , cord-028721-x6f26ahr 2479 20 origin origin NN cord-028721-x6f26ahr 2479 21 ( ( -LRB- cord-028721-x6f26ahr 2479 22 congenital congenital JJ cord-028721-x6f26ahr 2479 23 or or CC cord-028721-x6f26ahr 2479 24 acquired acquire VBN cord-028721-x6f26ahr 2479 25 ) ) -RRB- cord-028721-x6f26ahr 2479 26 , , , cord-028721-x6f26ahr 2479 27 and and CC cord-028721-x6f26ahr 2479 28 duration duration NN cord-028721-x6f26ahr 2479 29 of of IN cord-028721-x6f26ahr 2479 30 the the DT cord-028721-x6f26ahr 2479 31 obstruction obstruction NN cord-028721-x6f26ahr 2479 32 . . . cord-028721-x6f26ahr 2480 1 Location location NN cord-028721-x6f26ahr 2480 2 of of IN cord-028721-x6f26ahr 2480 3 obstruction obstruction NN cord-028721-x6f26ahr 2480 4 Obstruction obstruction NN cord-028721-x6f26ahr 2480 5 at at IN cord-028721-x6f26ahr 2480 6 the the DT cord-028721-x6f26ahr 2480 7 level level NN cord-028721-x6f26ahr 2480 8 of of IN cord-028721-x6f26ahr 2480 9 the the DT cord-028721-x6f26ahr 2480 10 ampulla ampulla NN cord-028721-x6f26ahr 2480 11 of of IN cord-028721-x6f26ahr 2480 12 the the DT cord-028721-x6f26ahr 2480 13 vas vas NNP cord-028721-x6f26ahr 2480 14 deferens deferen NNS cord-028721-x6f26ahr 2480 15 , , , cord-028721-x6f26ahr 2480 16 seminal seminal JJ cord-028721-x6f26ahr 2480 17 vesicles vesicle NNS cord-028721-x6f26ahr 2480 18 , , , cord-028721-x6f26ahr 2480 19 or or CC cord-028721-x6f26ahr 2480 20 ejaculatory ejaculatory NN cord-028721-x6f26ahr 2480 21 ducts duct NNS cord-028721-x6f26ahr 2480 22 does do VBZ cord-028721-x6f26ahr 2480 23 not not RB cord-028721-x6f26ahr 2480 24 usually usually RB cord-028721-x6f26ahr 2480 25 cause cause VB cord-028721-x6f26ahr 2480 26 signifi signifi NNP cord-028721-x6f26ahr 2480 27 ca can MD cord-028721-x6f26ahr 2480 28 nt not RB cord-028721-x6f26ahr 2480 29 lesions lesion NNS cord-028721-x6f26ahr 2480 30 in in IN cord-028721-x6f26ahr 2480 31 the the DT cord-028721-x6f26ahr 2480 32 testis testis NN cord-028721-x6f26ahr 2480 33 or or CC cord-028721-x6f26ahr 2480 34 epididymis epididymis NN cord-028721-x6f26ahr 2480 35 . . . cord-028721-x6f26ahr 2481 1 More more RBR cord-028721-x6f26ahr 2481 2 proximal proximal JJ cord-028721-x6f26ahr 2481 3 obstruction obstruction NN cord-028721-x6f26ahr 2481 4 at at IN cord-028721-x6f26ahr 2481 5 the the DT cord-028721-x6f26ahr 2481 6 level level NN cord-028721-x6f26ahr 2481 7 of of IN cord-028721-x6f26ahr 2481 8 the the DT cord-028721-x6f26ahr 2481 9 vas vas FW cord-028721-x6f26ahr 2481 10 deferens deferen NNS cord-028721-x6f26ahr 2481 11 , , , cord-028721-x6f26ahr 2481 12 epididymis epididymis NN cord-028721-x6f26ahr 2481 13 , , , cord-028721-x6f26ahr 2481 14 or or CC cord-028721-x6f26ahr 2481 15 testis testis NN cord-028721-x6f26ahr 2481 16 - - HYPH cord-028721-x6f26ahr 2481 17 epididymis epididymis NN cord-028721-x6f26ahr 2481 18 junction junction NN cord-028721-x6f26ahr 2481 19 usually usually RB cord-028721-x6f26ahr 2481 20 causes cause VBZ cord-028721-x6f26ahr 2481 21 severe severe JJ cord-028721-x6f26ahr 2481 22 lesions lesion NNS cord-028721-x6f26ahr 2481 23 in in IN cord-028721-x6f26ahr 2481 24 both both CC cord-028721-x6f26ahr 2481 25 the the DT cord-028721-x6f26ahr 2481 26 sperm sperm NN cord-028721-x6f26ahr 2481 27 excretory excretory JJ cord-028721-x6f26ahr 2481 28 ducts duct NNS cord-028721-x6f26ahr 2481 29 and and CC cord-028721-x6f26ahr 2481 30 the the DT cord-028721-x6f26ahr 2481 31 testicular testicular JJ cord-028721-x6f26ahr 2481 32 parenchyma parenchyma NN cord-028721-x6f26ahr 2481 33 . . . cord-028721-x6f26ahr 2482 1 Obstruction obstruction NN cord-028721-x6f26ahr 2482 2 of of IN cord-028721-x6f26ahr 2482 3 the the DT cord-028721-x6f26ahr 2482 4 vas vas FW cord-028721-x6f26ahr 2482 5 deferens deferen NNS cord-028721-x6f26ahr 2482 6 causes cause NNS cord-028721-x6f26ahr 2482 7 increased increase VBN cord-028721-x6f26ahr 2482 8 pressure pressure NN cord-028721-x6f26ahr 2482 9 within within IN cord-028721-x6f26ahr 2482 10 the the DT cord-028721-x6f26ahr 2482 11 ductus ductus NN cord-028721-x6f26ahr 2482 12 epididymis epididymis NN cord-028721-x6f26ahr 2482 13 . . . cord-028721-x6f26ahr 2483 1 As as IN cord-028721-x6f26ahr 2483 2 a a DT cord-028721-x6f26ahr 2483 3 result result NN cord-028721-x6f26ahr 2483 4 , , , cord-028721-x6f26ahr 2483 5 epididymal epididymal JJ cord-028721-x6f26ahr 2483 6 lumina lumina NNP cord-028721-x6f26ahr 2483 7 dilate dilate VBP cord-028721-x6f26ahr 2483 8 , , , cord-028721-x6f26ahr 2483 9 the the DT cord-028721-x6f26ahr 2483 10 epithelium epithelium NN cord-028721-x6f26ahr 2483 11 atrophies atrophy VBZ cord-028721-x6f26ahr 2483 12 , , , cord-028721-x6f26ahr 2483 13 and and CC cord-028721-x6f26ahr 2483 14 fl fl NNP cord-028721-x6f26ahr 2483 15 uid uid NN cord-028721-x6f26ahr 2483 16 containing contain VBG cord-028721-x6f26ahr 2483 17 few few JJ cord-028721-x6f26ahr 2483 18 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2483 19 and and CC cord-028721-x6f26ahr 2483 20 some some DT cord-028721-x6f26ahr 2483 21 spermiophages spermiophage NNS cord-028721-x6f26ahr 2483 22 accumulates accumulate VBZ cord-028721-x6f26ahr 2483 23 in in IN cord-028721-x6f26ahr 2483 24 the the DT cord-028721-x6f26ahr 2483 25 lumen lumen NN cord-028721-x6f26ahr 2484 1 ( ( -LRB- cord-028721-x6f26ahr 2484 2 Fig Fig NNP cord-028721-x6f26ahr 2484 3 . . . cord-028721-x6f26ahr 2484 4 12 12 CD cord-028721-x6f26ahr 2484 5 - - SYM cord-028721-x6f26ahr 2484 6 120 120 CD cord-028721-x6f26ahr 2484 7 ) ) -RRB- cord-028721-x6f26ahr 2484 8 . . . cord-028721-x6f26ahr 2485 1 The the DT cord-028721-x6f26ahr 2485 2 most most RBS cord-028721-x6f26ahr 2485 3 dilated dilated JJ cord-028721-x6f26ahr 2485 4 epididymal epididymal JJ cord-028721-x6f26ahr 2485 5 segment segment NN cord-028721-x6f26ahr 2485 6 is be VBZ cord-028721-x6f26ahr 2485 7 the the DT cord-028721-x6f26ahr 2485 8 caput caput NN cord-028721-x6f26ahr 2485 9 . . . cord-028721-x6f26ahr 2486 1 The the DT cord-028721-x6f26ahr 2486 2 ductuli ductuli NNP cord-028721-x6f26ahr 2486 3 efferentes efferente NNS cord-028721-x6f26ahr 2486 4 often often RB cord-028721-x6f26ahr 2486 5 become become VBP cord-028721-x6f26ahr 2486 6 cystically cystically RB cord-028721-x6f26ahr 2486 7 dilated dilate VBN cord-028721-x6f26ahr 2486 8 and and CC cord-028721-x6f26ahr 2486 9 fi fi NNP cord-028721-x6f26ahr 2486 10 lled lle VBD cord-028721-x6f26ahr 2486 11 with with IN cord-028721-x6f26ahr 2486 12 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2486 13 and and CC cord-028721-x6f26ahr 2486 14 macrophages macrophage NNS cord-028721-x6f26ahr 2486 15 . . . cord-028721-x6f26ahr 2487 1 From from IN cord-028721-x6f26ahr 2487 2 reabsorption reabsorption NN cord-028721-x6f26ahr 2487 3 and and CC cord-028721-x6f26ahr 2487 4 lysosomal lysosomal JJ cord-028721-x6f26ahr 2487 5 degradation degradation NN cord-028721-x6f26ahr 2487 6 of of IN cord-028721-x6f26ahr 2487 7 this this DT cord-028721-x6f26ahr 2487 8 protein protein NN cord-028721-x6f26ahr 2487 9 - - HYPH cord-028721-x6f26ahr 2487 10 rich rich JJ cord-028721-x6f26ahr 2487 11 fl fl NNP cord-028721-x6f26ahr 2487 12 uid uid NN cord-028721-x6f26ahr 2487 13 , , , cord-028721-x6f26ahr 2487 14 the the DT cord-028721-x6f26ahr 2487 15 epithelium epithelium NN cord-028721-x6f26ahr 2487 16 accumulates accumulate VBZ cord-028721-x6f26ahr 2487 17 lipofuscin lipofuscin NNP cord-028721-x6f26ahr 2487 18 granules granule NNS cord-028721-x6f26ahr 2487 19 or or CC cord-028721-x6f26ahr 2487 20 aquires aquire VBZ cord-028721-x6f26ahr 2487 21 apical apical JJ cord-028721-x6f26ahr 2487 22 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 2487 23 granules granule NNS cord-028721-x6f26ahr 2487 24 ( ( -LRB- cord-028721-x6f26ahr 2487 25 Paneth Paneth NNP cord-028721-x6f26ahr 2487 26 cell cell NN cord-028721-x6f26ahr 2487 27 - - HYPH cord-028721-x6f26ahr 2487 28 like like JJ cord-028721-x6f26ahr 2487 29 change change NN cord-028721-x6f26ahr 2487 30 ) ) -RRB- cord-028721-x6f26ahr 2487 31 . . . cord-028721-x6f26ahr 2488 1 1062 1062 CD cord-028721-x6f26ahr 2488 2 Rupture rupture NN cord-028721-x6f26ahr 2488 3 of of IN cord-028721-x6f26ahr 2488 4 the the DT cord-028721-x6f26ahr 2488 5 vas vas FW cord-028721-x6f26ahr 2488 6 deferens deferens NNP cord-028721-x6f26ahr 2488 7 gives give VBZ cord-028721-x6f26ahr 2488 8 rise rise NN cord-028721-x6f26ahr 2488 9 to to IN cord-028721-x6f26ahr 2488 10 microgranulomas microgranulomas NNP cord-028721-x6f26ahr 2488 11 and and CC cord-028721-x6f26ahr 2488 12 ceroid ceroid NNP cord-028721-x6f26ahr 2488 13 granuloma granuloma NN cord-028721-x6f26ahr 2488 14 ( ( -LRB- cord-028721-x6f26ahr 2488 15 Fig Fig NNP cord-028721-x6f26ahr 2488 16 . . . cord-028721-x6f26ahr 2488 17 12 12 CD cord-028721-x6f26ahr 2488 18 - - SYM cord-028721-x6f26ahr 2488 19 121 121 CD cord-028721-x6f26ahr 2488 20 ) ) -RRB- cord-028721-x6f26ahr 2488 21 . . . cord-028721-x6f26ahr 2489 1 Macrophages macrophage NNS cord-028721-x6f26ahr 2489 2 and and CC cord-028721-x6f26ahr 2489 3 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 2489 4 are be VBP cord-028721-x6f26ahr 2489 5 often often RB cord-028721-x6f26ahr 2489 6 present present JJ cord-028721-x6f26ahr 2489 7 in in IN cord-028721-x6f26ahr 2489 8 the the DT cord-028721-x6f26ahr 2489 9 intertubular intertubular JJ cord-028721-x6f26ahr 2489 10 connective connective JJ cord-028721-x6f26ahr 2489 11 tissue tissue NN cord-028721-x6f26ahr 2489 12 . . . cord-028721-x6f26ahr 2490 1 1063 1063 CD cord-028721-x6f26ahr 2491 1 The the DT cord-028721-x6f26ahr 2491 2 most most RBS cord-028721-x6f26ahr 2491 3 frequent frequent JJ cord-028721-x6f26ahr 2491 4 testicular testicular JJ cord-028721-x6f26ahr 2491 5 lesions lesion NNS cord-028721-x6f26ahr 2491 6 in in IN cord-028721-x6f26ahr 2491 7 proximal proximal JJ cord-028721-x6f26ahr 2491 8 obstruction obstruction NN cord-028721-x6f26ahr 2491 9 involve involve VBP cord-028721-x6f26ahr 2491 10 the the DT cord-028721-x6f26ahr 2491 11 adluminal adluminal NNP cord-028721-x6f26ahr 2491 12 compartment compartment NNP cord-028721-x6f26ahr 2491 13 , , , cord-028721-x6f26ahr 2491 14 and and CC cord-028721-x6f26ahr 2491 15 are be VBP cord-028721-x6f26ahr 2491 16 the the DT cord-028721-x6f26ahr 2491 17 result result NN cord-028721-x6f26ahr 2491 18 of of IN cord-028721-x6f26ahr 2491 19 the the DT cord-028721-x6f26ahr 2491 20 negative negative JJ cord-028721-x6f26ahr 2491 21 effect effect NN cord-028721-x6f26ahr 2491 22 of of IN cord-028721-x6f26ahr 2491 23 hydrostatic hydrostatic JJ cord-028721-x6f26ahr 2491 24 pressure pressure NN cord-028721-x6f26ahr 2491 25 on on IN cord-028721-x6f26ahr 2491 26 the the DT cord-028721-x6f26ahr 2491 27 seminiferous seminiferous JJ cord-028721-x6f26ahr 2491 28 tubular tubular JJ cord-028721-x6f26ahr 2491 29 cell cell NN cord-028721-x6f26ahr 2491 30 layers layer NNS cord-028721-x6f26ahr 2491 31 and and CC cord-028721-x6f26ahr 2491 32 , , , cord-028721-x6f26ahr 2491 33 in in IN cord-028721-x6f26ahr 2491 34 particular particular JJ cord-028721-x6f26ahr 2491 35 , , , cord-028721-x6f26ahr 2491 36 on on IN cord-028721-x6f26ahr 2491 37 the the DT cord-028721-x6f26ahr 2491 38 Sertoli sertoli JJ cord-028721-x6f26ahr 2491 39 cell cell NN cord-028721-x6f26ahr 2491 40 ( ( -LRB- cord-028721-x6f26ahr 2491 41 Figs Figs NNP cord-028721-x6f26ahr 2491 42 12 12 CD cord-028721-x6f26ahr 2491 43 - - HYPH cord-028721-x6f26ahr 2491 44 122 122 CD cord-028721-x6f26ahr 2491 45 - - HYPH cord-028721-x6f26ahr 2491 46 12 12 CD cord-028721-x6f26ahr 2491 47 - - SYM cord-028721-x6f26ahr 2491 48 124 124 CD cord-028721-x6f26ahr 2491 49 ) ) -RRB- cord-028721-x6f26ahr 2491 50 . . . cord-028721-x6f26ahr 2492 1 Etiology etiology NN cord-028721-x6f26ahr 2492 2 of of IN cord-028721-x6f26ahr 2492 3 obstruction obstruction NN cord-028721-x6f26ahr 2492 4 Obstruction obstruction NN cord-028721-x6f26ahr 2492 5 secondary secondary JJ cord-028721-x6f26ahr 2492 6 to to IN cord-028721-x6f26ahr 2492 7 congenital congenital JJ cord-028721-x6f26ahr 2492 8 absence absence NN cord-028721-x6f26ahr 2492 9 of of IN cord-028721-x6f26ahr 2492 10 the the DT cord-028721-x6f26ahr 2492 11 vas vas FW cord-028721-x6f26ahr 2492 12 deferens deferen NNS cord-028721-x6f26ahr 2492 13 usually usually RB cord-028721-x6f26ahr 2492 14 causes cause VBZ cord-028721-x6f26ahr 2492 15 little little JJ cord-028721-x6f26ahr 2492 16 testicular testicular JJ cord-028721-x6f26ahr 2492 17 injury injury NN cord-028721-x6f26ahr 2492 18 , , , cord-028721-x6f26ahr 2492 19 mainly mainly RB cord-028721-x6f26ahr 2492 20 dilation dilation NN cord-028721-x6f26ahr 2492 21 of of IN cord-028721-x6f26ahr 2492 22 the the DT cord-028721-x6f26ahr 2492 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 2492 24 tubules tubule NNS cord-028721-x6f26ahr 2492 25 and and CC cord-028721-x6f26ahr 2492 26 an an DT cord-028721-x6f26ahr 2492 27 increase increase NN cord-028721-x6f26ahr 2492 28 in in IN cord-028721-x6f26ahr 2492 29 the the DT cord-028721-x6f26ahr 2492 30 number number NN cord-028721-x6f26ahr 2492 31 of of IN cord-028721-x6f26ahr 2492 32 mature mature JJ cord-028721-x6f26ahr 2492 33 ( ( -LRB- cord-028721-x6f26ahr 2492 34 S s NN cord-028721-x6f26ahr 2492 35 c c NN cord-028721-x6f26ahr 2492 36 + + CC cord-028721-x6f26ahr 2492 37 S s NN cord-028721-x6f26ahr 2492 38 d d NN cord-028721-x6f26ahr 2492 39 ) ) -RRB- cord-028721-x6f26ahr 2492 40 spermatids spermatid NNS cord-028721-x6f26ahr 2492 41 . . . cord-028721-x6f26ahr 2493 1 1064 1064 CD cord-028721-x6f26ahr 2493 2 Lesions lesion NNS cord-028721-x6f26ahr 2493 3 resulting result VBG cord-028721-x6f26ahr 2493 4 from from IN cord-028721-x6f26ahr 2493 5 vasectomy vasectomy NN cord-028721-x6f26ahr 2493 6 are be VBP cord-028721-x6f26ahr 2493 7 more more RBR cord-028721-x6f26ahr 2493 8 important important JJ cord-028721-x6f26ahr 2493 9 . . . cord-028721-x6f26ahr 2494 1 Increased increase VBN cord-028721-x6f26ahr 2494 2 intraluminal intraluminal JJ cord-028721-x6f26ahr 2494 3 pressure pressure NN cord-028721-x6f26ahr 2494 4 in in IN cord-028721-x6f26ahr 2494 5 the the DT cord-028721-x6f26ahr 2494 6 epididymis epididymis NN cord-028721-x6f26ahr 2494 7 1065 1065 CD cord-028721-x6f26ahr 2494 8 may may MD cord-028721-x6f26ahr 2494 9 give give VB cord-028721-x6f26ahr 2494 10 rise rise NN cord-028721-x6f26ahr 2494 11 to to IN cord-028721-x6f26ahr 2494 12 pain pain NN cord-028721-x6f26ahr 2494 13 ( ( -LRB- cord-028721-x6f26ahr 2494 14 late late JJ cord-028721-x6f26ahr 2494 15 post post JJ cord-028721-x6f26ahr 2494 16 - - JJ cord-028721-x6f26ahr 2494 17 vasectomy vasectomy JJ cord-028721-x6f26ahr 2494 18 syndrome syndrome NN cord-028721-x6f26ahr 2494 19 ) ) -RRB- cord-028721-x6f26ahr 2494 20 . . . cord-028721-x6f26ahr 2495 1 1066 1066 CD cord-028721-x6f26ahr 2496 1 Testicular testicular JJ cord-028721-x6f26ahr 2496 2 lesions lesion NNS cord-028721-x6f26ahr 2496 3 depend depend VBP cord-028721-x6f26ahr 2496 4 on on IN cord-028721-x6f26ahr 2496 5 the the DT cord-028721-x6f26ahr 2496 6 surgical surgical JJ cord-028721-x6f26ahr 2496 7 technique technique NN cord-028721-x6f26ahr 2496 8 used use VBN cord-028721-x6f26ahr 2496 9 : : : cord-028721-x6f26ahr 2496 10 they -PRON- PRP cord-028721-x6f26ahr 2496 11 are be VBP cord-028721-x6f26ahr 2496 12 slight slight JJ cord-028721-x6f26ahr 2496 13 if if IN cord-028721-x6f26ahr 2496 14 the the DT cord-028721-x6f26ahr 2496 15 proximal proximal JJ cord-028721-x6f26ahr 2496 16 end end NN cord-028721-x6f26ahr 2496 17 of of IN cord-028721-x6f26ahr 2496 18 the the DT cord-028721-x6f26ahr 2496 19 vas vas NNP cord-028721-x6f26ahr 2496 20 deferens deferens NN cord-028721-x6f26ahr 2496 21 is be VBZ cord-028721-x6f26ahr 2496 22 not not RB cord-028721-x6f26ahr 2496 23 ligated ligate VBN cord-028721-x6f26ahr 2496 24 or or CC cord-028721-x6f26ahr 2496 25 sperm sperm NN cord-028721-x6f26ahr 2496 26 granuloma granuloma NN cord-028721-x6f26ahr 2496 27 forms form NNS cord-028721-x6f26ahr 2496 28 at at IN cord-028721-x6f26ahr 2496 29 the the DT cord-028721-x6f26ahr 2496 30 site site NN cord-028721-x6f26ahr 2496 31 of of IN cord-028721-x6f26ahr 2496 32 vasectomy vasectomy NN cord-028721-x6f26ahr 2496 33 . . . cord-028721-x6f26ahr 2497 1 The the DT cord-028721-x6f26ahr 2497 2 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 2497 3 rhythm rhythm NN cord-028721-x6f26ahr 2497 4 in in IN cord-028721-x6f26ahr 2497 5 the the DT cord-028721-x6f26ahr 2497 6 testis testis NN cord-028721-x6f26ahr 2497 7 is be VBZ cord-028721-x6f26ahr 2497 8 slower slow JJR cord-028721-x6f26ahr 2497 9 than than IN cord-028721-x6f26ahr 2497 10 before before IN cord-028721-x6f26ahr 2497 11 vasectomy vasectomy NN cord-028721-x6f26ahr 2497 12 , , , cord-028721-x6f26ahr 2497 13 and and CC cord-028721-x6f26ahr 2497 14 lesions lesion NNS cord-028721-x6f26ahr 2497 15 characteristic characteristic JJ cord-028721-x6f26ahr 2497 16 of of IN cord-028721-x6f26ahr 2497 17 testicular testicular JJ cord-028721-x6f26ahr 2497 18 obstruction obstruction NN cord-028721-x6f26ahr 2497 19 develop develop NN cord-028721-x6f26ahr 2497 20 , , , cord-028721-x6f26ahr 2497 21 including include VBG cord-028721-x6f26ahr 2497 22 thickening thickening NN cord-028721-x6f26ahr 2497 23 of of IN cord-028721-x6f26ahr 2497 24 the the DT cord-028721-x6f26ahr 2497 25 lamina lamina JJ cord-028721-x6f26ahr 2497 26 propria propria NNP cord-028721-x6f26ahr 2497 27 and and CC cord-028721-x6f26ahr 2497 28 fi fi NNP cord-028721-x6f26ahr 2497 29 brosis brosis NN cord-028721-x6f26ahr 2497 30 of of IN cord-028721-x6f26ahr 2497 31 the the DT cord-028721-x6f26ahr 2497 32 interstitium interstitium NN cord-028721-x6f26ahr 2497 33 . . . cord-028721-x6f26ahr 2498 1 1067 1067 CD cord-028721-x6f26ahr 2498 2 , , , cord-028721-x6f26ahr 2498 3 1068 1068 CD cord-028721-x6f26ahr 2499 1 In in IN cord-028721-x6f26ahr 2499 2 testicular testicular JJ cord-028721-x6f26ahr 2499 3 obstruction obstruction NN cord-028721-x6f26ahr 2499 4 secondary secondary JJ cord-028721-x6f26ahr 2499 5 to to IN cord-028721-x6f26ahr 2499 6 herniorrhaphy herniorrhaphy NN cord-028721-x6f26ahr 2499 7 in in IN cord-028721-x6f26ahr 2499 8 infancy infancy NN cord-028721-x6f26ahr 2499 9 , , , cord-028721-x6f26ahr 2499 10 testicular testicular JJ cord-028721-x6f26ahr 2499 11 lesions lesion NNS cord-028721-x6f26ahr 2499 12 are be VBP cord-028721-x6f26ahr 2499 13 mild mild JJ cord-028721-x6f26ahr 2499 14 . . . cord-028721-x6f26ahr 2500 1 Testicular testicular JJ cord-028721-x6f26ahr 2500 2 lesions lesion NNS cord-028721-x6f26ahr 2500 3 may may MD cord-028721-x6f26ahr 2500 4 be be VB cord-028721-x6f26ahr 2500 5 important important JJ cord-028721-x6f26ahr 2500 6 if if IN cord-028721-x6f26ahr 2500 7 the the DT cord-028721-x6f26ahr 2500 8 epididymis epididymis NN cord-028721-x6f26ahr 2500 9 is be VBZ cord-028721-x6f26ahr 2500 10 damaged damage VBN cord-028721-x6f26ahr 2500 11 by by IN cord-028721-x6f26ahr 2500 12 hydrocelectomy hydrocelectomy NN cord-028721-x6f26ahr 2500 13 , , , cord-028721-x6f26ahr 2500 14 and and CC cord-028721-x6f26ahr 2500 15 consist consist VBP cord-028721-x6f26ahr 2500 16 mainly mainly RB cord-028721-x6f26ahr 2500 17 of of IN cord-028721-x6f26ahr 2500 18 primary primary JJ cord-028721-x6f26ahr 2500 19 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2500 20 sloughing sloughing NN cord-028721-x6f26ahr 2500 21 . . . cord-028721-x6f26ahr 2501 1 In in IN cord-028721-x6f26ahr 2501 2 addition addition NN cord-028721-x6f26ahr 2501 3 to to IN cord-028721-x6f26ahr 2501 4 these these DT cord-028721-x6f26ahr 2501 5 lesions lesion NNS cord-028721-x6f26ahr 2501 6 , , , cord-028721-x6f26ahr 2501 7 hyalinized hyalinized JJ cord-028721-x6f26ahr 2501 8 tubules tubule NNS cord-028721-x6f26ahr 2501 9 may may MD cord-028721-x6f26ahr 2501 10 be be VB cord-028721-x6f26ahr 2501 11 observed observe VBN cord-028721-x6f26ahr 2501 12 when when WRB cord-028721-x6f26ahr 2501 13 obstruction obstruction NN cord-028721-x6f26ahr 2501 14 is be VBZ cord-028721-x6f26ahr 2501 15 caused cause VBN cord-028721-x6f26ahr 2501 16 by by IN cord-028721-x6f26ahr 2501 17 infl infl NNP cord-028721-x6f26ahr 2501 18 ammation ammation NNP cord-028721-x6f26ahr 2501 19 . . . cord-028721-x6f26ahr 2502 1 In in IN cord-028721-x6f26ahr 2502 2 acquired acquire VBN cord-028721-x6f26ahr 2502 3 obstruction obstruction NN cord-028721-x6f26ahr 2502 4 the the DT cord-028721-x6f26ahr 2502 5 testicular testicular JJ cord-028721-x6f26ahr 2502 6 lesions lesion NNS cord-028721-x6f26ahr 2502 7 worsen worsen VBP cord-028721-x6f26ahr 2502 8 with with IN cord-028721-x6f26ahr 2502 9 time time NN cord-028721-x6f26ahr 2502 10 . . . cord-028721-x6f26ahr 2503 1 Obstruction obstruction NN cord-028721-x6f26ahr 2503 2 in in IN cord-028721-x6f26ahr 2503 3 the the DT cord-028721-x6f26ahr 2503 4 caput caput NN cord-028721-x6f26ahr 2503 5 of of IN cord-028721-x6f26ahr 2503 6 the the DT cord-028721-x6f26ahr 2503 7 epididymis epididymis NN cord-028721-x6f26ahr 2503 8 leads lead VBZ cord-028721-x6f26ahr 2503 9 to to IN cord-028721-x6f26ahr 2503 10 disappearance disappearance NN cord-028721-x6f26ahr 2503 11 of of IN cord-028721-x6f26ahr 2503 12 all all DT cord-028721-x6f26ahr 2503 13 germ germ NN cord-028721-x6f26ahr 2503 14 cells cell NNS cord-028721-x6f26ahr 2503 15 in in IN cord-028721-x6f26ahr 2503 16 the the DT cord-028721-x6f26ahr 2503 17 adluminal adluminal NNP cord-028721-x6f26ahr 2503 18 compartment compartment NNP cord-028721-x6f26ahr 2503 19 of of IN cord-028721-x6f26ahr 2503 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 2503 21 tubules tubule NNS cord-028721-x6f26ahr 2503 22 . . . cord-028721-x6f26ahr 2504 1 The the DT cord-028721-x6f26ahr 2504 2 tubules tubule NNS cord-028721-x6f26ahr 2504 3 become become VBP cord-028721-x6f26ahr 2504 4 dilated dilated JJ cord-028721-x6f26ahr 2504 5 and and CC cord-028721-x6f26ahr 2504 6 Sertoli sertoli JJ cord-028721-x6f26ahr 2504 7 cells cell NNS cord-028721-x6f26ahr 2504 8 appear appear VBP cord-028721-x6f26ahr 2504 9 vacuolated vacuolate VBN cord-028721-x6f26ahr 2504 10 . . . cord-028721-x6f26ahr 2505 1 Testicular testicular JJ cord-028721-x6f26ahr 2505 2 alterations alteration NNS cord-028721-x6f26ahr 2505 3 after after IN cord-028721-x6f26ahr 2505 4 vasectomy vasectomy NN cord-028721-x6f26ahr 2505 5 may may MD cord-028721-x6f26ahr 2505 6 not not RB cord-028721-x6f26ahr 2505 7 be be VB cord-028721-x6f26ahr 2505 8 related relate VBN cord-028721-x6f26ahr 2505 9 to to IN cord-028721-x6f26ahr 2505 10 the the DT cord-028721-x6f26ahr 2505 11 duration duration NN cord-028721-x6f26ahr 2505 12 of of IN cord-028721-x6f26ahr 2505 13 the the DT cord-028721-x6f26ahr 2505 14 obstruction obstruction NN cord-028721-x6f26ahr 2505 15 but but CC cord-028721-x6f26ahr 2505 16 rather rather RB cord-028721-x6f26ahr 2505 17 to to IN cord-028721-x6f26ahr 2505 18 the the DT cord-028721-x6f26ahr 2505 19 initial initial JJ cord-028721-x6f26ahr 2505 20 injury injury NN cord-028721-x6f26ahr 2505 21 , , , cord-028721-x6f26ahr 2505 22 and and CC cord-028721-x6f26ahr 2505 23 may may MD cord-028721-x6f26ahr 2505 24 disappear disappear VB cord-028721-x6f26ahr 2505 25 with with IN cord-028721-x6f26ahr 2505 26 time time NN cord-028721-x6f26ahr 2505 27 as as IN cord-028721-x6f26ahr 2505 28 the the DT cord-028721-x6f26ahr 2505 29 intraluminal intraluminal JJ cord-028721-x6f26ahr 2505 30 pressure pressure NN cord-028721-x6f26ahr 2505 31 decreases decrease VBZ cord-028721-x6f26ahr 2505 32 . . . cord-028721-x6f26ahr 2506 1 1069 1069 CD cord-028721-x6f26ahr 2507 1 However however RB cord-028721-x6f26ahr 2507 2 , , , cord-028721-x6f26ahr 2507 3 if if IN cord-028721-x6f26ahr 2507 4 a a DT cord-028721-x6f26ahr 2507 5 signifi signifi NN cord-028721-x6f26ahr 2507 6 ca can MD cord-028721-x6f26ahr 2507 7 nt not RB cord-028721-x6f26ahr 2507 8 amount amount NN cord-028721-x6f26ahr 2507 9 of of IN cord-028721-x6f26ahr 2507 10 time time NN cord-028721-x6f26ahr 2507 11 has have VBZ cord-028721-x6f26ahr 2507 12 elapsed elapse VBN cord-028721-x6f26ahr 2507 13 after after IN cord-028721-x6f26ahr 2507 14 vasectomy vasectomy NN cord-028721-x6f26ahr 2507 15 , , , cord-028721-x6f26ahr 2507 16 the the DT cord-028721-x6f26ahr 2507 17 possibility possibility NN cord-028721-x6f26ahr 2507 18 of of IN cord-028721-x6f26ahr 2507 19 attaining attain VBG cord-028721-x6f26ahr 2507 20 a a DT cord-028721-x6f26ahr 2507 21 normal normal JJ cord-028721-x6f26ahr 2507 22 spermiogram spermiogram NN cord-028721-x6f26ahr 2507 23 with with IN cord-028721-x6f26ahr 2507 24 vasovasostomy vasovasostomy NN cord-028721-x6f26ahr 2507 25 is be VBZ cord-028721-x6f26ahr 2507 26 very very RB cord-028721-x6f26ahr 2507 27 low low JJ cord-028721-x6f26ahr 2507 28 . . . cord-028721-x6f26ahr 2508 1 Vasal Vasal NNP cord-028721-x6f26ahr 2508 2 patency patency NN cord-028721-x6f26ahr 2508 3 is be VBZ cord-028721-x6f26ahr 2508 4 restored restore VBN cord-028721-x6f26ahr 2508 5 in in IN cord-028721-x6f26ahr 2508 6 most most JJS cord-028721-x6f26ahr 2508 7 cases case NNS cord-028721-x6f26ahr 2508 8 of of IN cord-028721-x6f26ahr 2508 9 reanastomosis reanastomosis NN cord-028721-x6f26ahr 2508 10 , , , cord-028721-x6f26ahr 2508 11 but but CC cord-028721-x6f26ahr 2508 12 paternity paternity NN cord-028721-x6f26ahr 2508 13 rates rate NNS cord-028721-x6f26ahr 2508 14 are be VBP cord-028721-x6f26ahr 2508 15 markedly markedly RB cord-028721-x6f26ahr 2508 16 lower low JJR cord-028721-x6f26ahr 2508 17 ( ( -LRB- cord-028721-x6f26ahr 2508 18 25 25 CD cord-028721-x6f26ahr 2508 19 - - SYM cord-028721-x6f26ahr 2508 20 51 51 CD cord-028721-x6f26ahr 2508 21 % % NN cord-028721-x6f26ahr 2508 22 ) ) -RRB- cord-028721-x6f26ahr 2508 23 1069 1069 CD cord-028721-x6f26ahr 2508 24 than than IN cord-028721-x6f26ahr 2508 25 normal normal JJ cord-028721-x6f26ahr 2508 26 ( ( -LRB- cord-028721-x6f26ahr 2508 27 85 85 CD cord-028721-x6f26ahr 2508 28 % % NN cord-028721-x6f26ahr 2508 29 ) ) -RRB- cord-028721-x6f26ahr 2508 30 . . . cord-028721-x6f26ahr 2509 1 1070 1070 CD cord-028721-x6f26ahr 2509 2 _SP cord-028721-x6f26ahr 2510 1 Some some DT cord-028721-x6f26ahr 2510 2 azoospermic azoospermic NNP cord-028721-x6f26ahr 2510 3 patients patient NNS cord-028721-x6f26ahr 2510 4 have have VBP cord-028721-x6f26ahr 2510 5 testicular testicular JJ cord-028721-x6f26ahr 2510 6 biopsy biopsy JJ cord-028721-x6f26ahr 2510 7 with with IN cord-028721-x6f26ahr 2510 8 minimal minimal JJ cord-028721-x6f26ahr 2510 9 histologic histologic JJ cord-028721-x6f26ahr 2510 10 abnormality abnormality NN cord-028721-x6f26ahr 2510 11 or or CC cord-028721-x6f26ahr 2510 12 minor minor JJ cord-028721-x6f26ahr 2510 13 tubular tubular JJ cord-028721-x6f26ahr 2510 14 dilation dilation NN cord-028721-x6f26ahr 2510 15 without without IN cord-028721-x6f26ahr 2510 16 detectable detectable JJ cord-028721-x6f26ahr 2510 17 excretory excretory JJ cord-028721-x6f26ahr 2510 18 duct duct NN cord-028721-x6f26ahr 2510 19 obstruction obstruction NN cord-028721-x6f26ahr 2510 20 . . . cord-028721-x6f26ahr 2511 1 These these DT cord-028721-x6f26ahr 2511 2 fi fi NNP cord-028721-x6f26ahr 2511 3 ndings nding NNS cord-028721-x6f26ahr 2511 4 are be VBP cord-028721-x6f26ahr 2511 5 characteristic characteristic JJ cord-028721-x6f26ahr 2511 6 of of IN cord-028721-x6f26ahr 2511 7 two two CD cord-028721-x6f26ahr 2511 8 main main JJ cord-028721-x6f26ahr 2511 9 conditions condition NNS cord-028721-x6f26ahr 2511 10 : : : cord-028721-x6f26ahr 2511 11 Young Young NNP cord-028721-x6f26ahr 2511 12 's 's POS cord-028721-x6f26ahr 2511 13 syndrome syndrome NN cord-028721-x6f26ahr 2511 14 , , , cord-028721-x6f26ahr 2511 15 and and CC cord-028721-x6f26ahr 2511 16 alterations alteration NNS cord-028721-x6f26ahr 2511 17 in in IN cord-028721-x6f26ahr 2511 18 spermatozoal spermatozoal NNP cord-028721-x6f26ahr 2511 19 transport transport NN cord-028721-x6f26ahr 2511 20 . . . cord-028721-x6f26ahr 2512 1 Young Young NNP cord-028721-x6f26ahr 2512 2 's 's POS cord-028721-x6f26ahr 2512 3 syndrome syndrome NN cord-028721-x6f26ahr 2512 4 Young Young NNP cord-028721-x6f26ahr 2512 5 's 's POS cord-028721-x6f26ahr 2512 6 syndrome syndrome NN cord-028721-x6f26ahr 2512 7 is be VBZ cord-028721-x6f26ahr 2512 8 defi defi NNP cord-028721-x6f26ahr 2512 9 ned ned NNP cord-028721-x6f26ahr 2512 10 by by IN cord-028721-x6f26ahr 2512 11 the the DT cord-028721-x6f26ahr 2512 12 following follow VBG cord-028721-x6f26ahr 2512 13 constellation constellation NN cord-028721-x6f26ahr 2512 14 of of IN cord-028721-x6f26ahr 2512 15 fi fi NNP cord-028721-x6f26ahr 2512 16 ndings nding NNS cord-028721-x6f26ahr 2512 17 : : : cord-028721-x6f26ahr 2512 18 azoospermia azoospermia NN cord-028721-x6f26ahr 2512 19 , , , cord-028721-x6f26ahr 2512 20 sinusitis sinusitis NN cord-028721-x6f26ahr 2512 21 , , , cord-028721-x6f26ahr 2512 22 bronchitis bronchitis NN cord-028721-x6f26ahr 2512 23 or or CC cord-028721-x6f26ahr 2512 24 bronchiectasis bronchiectasis NN cord-028721-x6f26ahr 2512 25 , , , cord-028721-x6f26ahr 2512 26 and and CC cord-028721-x6f26ahr 2512 27 normal normal JJ cord-028721-x6f26ahr 2512 28 spermatozoal spermatozoal NNP cord-028721-x6f26ahr 2512 29 fl fl NNP cord-028721-x6f26ahr 2512 30 agella agella NNP cord-028721-x6f26ahr 2512 31 . . . cord-028721-x6f26ahr 2513 1 1071 1071 CD cord-028721-x6f26ahr 2514 1 The the DT cord-028721-x6f26ahr 2514 2 incidence incidence NN cord-028721-x6f26ahr 2514 3 is be VBZ cord-028721-x6f26ahr 2514 4 probably probably RB cord-028721-x6f26ahr 2514 5 higher high JJR cord-028721-x6f26ahr 2514 6 than than IN cord-028721-x6f26ahr 2514 7 that that DT cord-028721-x6f26ahr 2514 8 recorded record VBN cord-028721-x6f26ahr 2514 9 in in IN cord-028721-x6f26ahr 2514 10 the the DT cord-028721-x6f26ahr 2514 11 literature literature NN cord-028721-x6f26ahr 2514 12 , , , cord-028721-x6f26ahr 2514 13 and and CC cord-028721-x6f26ahr 2514 14 Young Young NNP cord-028721-x6f26ahr 2514 15 's 's POS cord-028721-x6f26ahr 2514 16 syndrome syndrome NN cord-028721-x6f26ahr 2514 17 should should MD cord-028721-x6f26ahr 2514 18 be be VB cord-028721-x6f26ahr 2514 19 suspected suspect VBN cord-028721-x6f26ahr 2514 20 in in IN cord-028721-x6f26ahr 2514 21 all all DT cord-028721-x6f26ahr 2514 22 patients patient NNS cord-028721-x6f26ahr 2514 23 with with IN cord-028721-x6f26ahr 2514 24 obstructive obstructive JJ cord-028721-x6f26ahr 2514 25 azoospermia azoospermia NN cord-028721-x6f26ahr 2514 26 without without IN cord-028721-x6f26ahr 2514 27 a a DT cord-028721-x6f26ahr 2514 28 history history NN cord-028721-x6f26ahr 2514 29 of of IN cord-028721-x6f26ahr 2514 30 epididymitis epididymitis NN cord-028721-x6f26ahr 2514 31 or or CC cord-028721-x6f26ahr 2514 32 scrotal scrotal JJ cord-028721-x6f26ahr 2514 33 trauma trauma NN cord-028721-x6f26ahr 2514 34 . . . cord-028721-x6f26ahr 2515 1 These these DT cord-028721-x6f26ahr 2515 2 patients patient NNS cord-028721-x6f26ahr 2515 3 have have VBP cord-028721-x6f26ahr 2515 4 a a DT cord-028721-x6f26ahr 2515 5 lesion lesion NN cord-028721-x6f26ahr 2515 6 at at IN cord-028721-x6f26ahr 2515 7 the the DT cord-028721-x6f26ahr 2515 8 junction junction NN cord-028721-x6f26ahr 2515 9 of of IN cord-028721-x6f26ahr 2515 10 the the DT cord-028721-x6f26ahr 2515 11 caput caput NNP cord-028721-x6f26ahr 2515 12 and and CC cord-028721-x6f26ahr 2515 13 corpus corpus NN cord-028721-x6f26ahr 2515 14 of of IN cord-028721-x6f26ahr 2515 15 the the DT cord-028721-x6f26ahr 2515 16 epididymis epididymis NN cord-028721-x6f26ahr 2515 17 that that WDT cord-028721-x6f26ahr 2515 18 gives give VBZ cord-028721-x6f26ahr 2515 19 the the DT cord-028721-x6f26ahr 2515 20 epididymis epididymis NN cord-028721-x6f26ahr 2515 21 a a DT cord-028721-x6f26ahr 2515 22 characteristic characteristic JJ cord-028721-x6f26ahr 2515 23 gross gross JJ cord-028721-x6f26ahr 2515 24 appearance appearance NN cord-028721-x6f26ahr 2515 25 . . . cord-028721-x6f26ahr 2516 1 The the DT cord-028721-x6f26ahr 2516 2 caput caput NN cord-028721-x6f26ahr 2516 3 of of IN cord-028721-x6f26ahr 2516 4 the the DT cord-028721-x6f26ahr 2516 5 epididymis epididymis NN cord-028721-x6f26ahr 2516 6 is be VBZ cord-028721-x6f26ahr 2516 7 distended distend VBN cord-028721-x6f26ahr 2516 8 , , , cord-028721-x6f26ahr 2516 9 the the DT cord-028721-x6f26ahr 2516 10 ductuli ductuli NNP cord-028721-x6f26ahr 2516 11 efferentes efferente NNS cord-028721-x6f26ahr 2516 12 contain contain VBP cord-028721-x6f26ahr 2516 13 yellowish yellowish JJ cord-028721-x6f26ahr 2516 14 fl fl JJ cord-028721-x6f26ahr 2516 15 uid uid NN cord-028721-x6f26ahr 2516 16 and and CC cord-028721-x6f26ahr 2516 17 numerous numerous JJ cord-028721-x6f26ahr 2516 18 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2516 19 , , , cord-028721-x6f26ahr 2516 20 and and CC cord-028721-x6f26ahr 2516 21 the the DT cord-028721-x6f26ahr 2516 22 remaining remain VBG cord-028721-x6f26ahr 2516 23 epididymal epididymal JJ cord-028721-x6f26ahr 2516 24 segments segment NNS cord-028721-x6f26ahr 2516 25 are be VBP cord-028721-x6f26ahr 2516 26 normal normal JJ cord-028721-x6f26ahr 2516 27 . . . cord-028721-x6f26ahr 2517 1 The the DT cord-028721-x6f26ahr 2517 2 ductus ductus NN cord-028721-x6f26ahr 2517 3 epididymidis epididymidis NN cord-028721-x6f26ahr 2517 4 is be VBZ cord-028721-x6f26ahr 2517 5 blocked block VBN cord-028721-x6f26ahr 2517 6 by by IN cord-028721-x6f26ahr 2517 7 thick thick JJ cord-028721-x6f26ahr 2517 8 fl fl NNP cord-028721-x6f26ahr 2517 9 uid uid NN cord-028721-x6f26ahr 2517 10 . . . cord-028721-x6f26ahr 2518 1 1072 1072 CD cord-028721-x6f26ahr 2519 1 Young Young NNP cord-028721-x6f26ahr 2519 2 's 's POS cord-028721-x6f26ahr 2519 3 syndrome syndrome NN cord-028721-x6f26ahr 2519 4 should should MD cord-028721-x6f26ahr 2519 5 be be VB cord-028721-x6f26ahr 2519 6 distinguished distinguish VBN cord-028721-x6f26ahr 2519 7 from from IN cord-028721-x6f26ahr 2519 8 other other JJ cord-028721-x6f26ahr 2519 9 causes cause NNS cord-028721-x6f26ahr 2519 10 of of IN cord-028721-x6f26ahr 2519 11 infertility infertility NN cord-028721-x6f26ahr 2519 12 also also RB cord-028721-x6f26ahr 2519 13 associated associate VBN cord-028721-x6f26ahr 2519 14 with with IN cord-028721-x6f26ahr 2519 15 chronic chronic JJ cord-028721-x6f26ahr 2519 16 sinusitis sinusitis NN cord-028721-x6f26ahr 2519 17 and and CC cord-028721-x6f26ahr 2519 18 pulmonary pulmonary JJ cord-028721-x6f26ahr 2519 19 infections infection NNS cord-028721-x6f26ahr 2519 20 , , , cord-028721-x6f26ahr 2519 21 including include VBG cord-028721-x6f26ahr 2519 22 ciliary ciliary NN cord-028721-x6f26ahr 2519 23 dyskinesia dyskinesia NN cord-028721-x6f26ahr 2519 24 and and CC cord-028721-x6f26ahr 2519 25 cystic cystic NN cord-028721-x6f26ahr 2519 26 fi fi NN cord-028721-x6f26ahr 2519 27 brosis brosis NN cord-028721-x6f26ahr 2519 28 . . . cord-028721-x6f26ahr 2520 1 Ciliary Ciliary NNP cord-028721-x6f26ahr 2520 2 dyskinesia dyskinesia NN cord-028721-x6f26ahr 2520 3 consists consist VBZ cord-028721-x6f26ahr 2520 4 of of IN cord-028721-x6f26ahr 2520 5 morphological morphological JJ cord-028721-x6f26ahr 2520 6 , , , cord-028721-x6f26ahr 2520 7 biochemical biochemical JJ cord-028721-x6f26ahr 2520 8 , , , cord-028721-x6f26ahr 2520 9 and and CC cord-028721-x6f26ahr 2520 10 functional functional JJ cord-028721-x6f26ahr 2520 11 alterations alteration NNS cord-028721-x6f26ahr 2520 12 in in IN cord-028721-x6f26ahr 2520 13 cilia cilium NNS cord-028721-x6f26ahr 2520 14 and and CC cord-028721-x6f26ahr 2520 15 fl fl NNP cord-028721-x6f26ahr 2520 16 agella agella NNP cord-028721-x6f26ahr 2520 17 , , , cord-028721-x6f26ahr 2520 18 and and CC cord-028721-x6f26ahr 2520 19 includes include VBZ cord-028721-x6f26ahr 2520 20 Infertility Infertility NNP cord-028721-x6f26ahr 2520 21 several several JJ cord-028721-x6f26ahr 2520 22 diseases disease NNS cord-028721-x6f26ahr 2520 23 such such JJ cord-028721-x6f26ahr 2520 24 as as IN cord-028721-x6f26ahr 2520 25 the the DT cord-028721-x6f26ahr 2520 26 immotile immotile NNP cord-028721-x6f26ahr 2520 27 cilia cilia NNP cord-028721-x6f26ahr 2520 28 syndrome syndrome NN cord-028721-x6f26ahr 2520 29 , , , cord-028721-x6f26ahr 2520 30 Kartagener Kartagener NNP cord-028721-x6f26ahr 2520 31 's 's POS cord-028721-x6f26ahr 2520 32 syndrome syndrome NN cord-028721-x6f26ahr 2520 33 , , , cord-028721-x6f26ahr 2520 34 and and CC cord-028721-x6f26ahr 2520 35 miscellaneous miscellaneous JJ cord-028721-x6f26ahr 2520 36 syndromes syndrome NNS cord-028721-x6f26ahr 2520 37 characterized characterize VBN cord-028721-x6f26ahr 2520 38 by by IN cord-028721-x6f26ahr 2520 39 imperfectly imperfectly RB cord-028721-x6f26ahr 2520 40 defi defi NNP cord-028721-x6f26ahr 2520 41 ned ned NNP cord-028721-x6f26ahr 2520 42 abnormalities abnormality NNS cord-028721-x6f26ahr 2520 43 of of IN cord-028721-x6f26ahr 2520 44 cilia cilium NNS cord-028721-x6f26ahr 2520 45 and and CC cord-028721-x6f26ahr 2520 46 fl fl NNP cord-028721-x6f26ahr 2520 47 agella agella NNP cord-028721-x6f26ahr 2520 48 . . . cord-028721-x6f26ahr 2521 1 1073 1073 CD cord-028721-x6f26ahr 2522 1 In in IN cord-028721-x6f26ahr 2522 2 Young Young NNP cord-028721-x6f26ahr 2522 3 's 's POS cord-028721-x6f26ahr 2522 4 syndrome syndrome NN cord-028721-x6f26ahr 2522 5 , , , cord-028721-x6f26ahr 2522 6 sinusitis sinusitis NN cord-028721-x6f26ahr 2522 7 and and CC cord-028721-x6f26ahr 2522 8 pulmonary pulmonary JJ cord-028721-x6f26ahr 2522 9 infections infection NNS cord-028721-x6f26ahr 2522 10 develop develop VBP cord-028721-x6f26ahr 2522 11 in in IN cord-028721-x6f26ahr 2522 12 childhood childhood NN cord-028721-x6f26ahr 2522 13 and and CC cord-028721-x6f26ahr 2522 14 stabilize stabilize VB cord-028721-x6f26ahr 2522 15 or or CC cord-028721-x6f26ahr 2522 16 improve improve VB cord-028721-x6f26ahr 2522 17 in in IN cord-028721-x6f26ahr 2522 18 adolescence adolescence NN cord-028721-x6f26ahr 2522 19 ; ; : cord-028721-x6f26ahr 2522 20 in in IN cord-028721-x6f26ahr 2522 21 other other JJ cord-028721-x6f26ahr 2522 22 conditions condition NNS cord-028721-x6f26ahr 2522 23 , , , cord-028721-x6f26ahr 2522 24 the the DT cord-028721-x6f26ahr 2522 25 pulmonary pulmonary JJ cord-028721-x6f26ahr 2522 26 damage damage NN cord-028721-x6f26ahr 2522 27 increases increase NNS cord-028721-x6f26ahr 2522 28 with with IN cord-028721-x6f26ahr 2522 29 age age NN cord-028721-x6f26ahr 2522 30 and and CC cord-028721-x6f26ahr 2522 31 the the DT cord-028721-x6f26ahr 2522 32 cilia cilium NNS cord-028721-x6f26ahr 2522 33 and and CC cord-028721-x6f26ahr 2522 34 fl fl NNP cord-028721-x6f26ahr 2522 35 agella agella NNS cord-028721-x6f26ahr 2522 36 are be VBP cord-028721-x6f26ahr 2522 37 ultrastructurally ultrastructurally RB cord-028721-x6f26ahr 2522 38 abnormal abnormal JJ cord-028721-x6f26ahr 2522 39 . . . cord-028721-x6f26ahr 2523 1 1074 1074 CD cord-028721-x6f26ahr 2523 2 Alterations alteration NNS cord-028721-x6f26ahr 2523 3 in in IN cord-028721-x6f26ahr 2523 4 spermatozoon spermatozoon NN cord-028721-x6f26ahr 2523 5 transport transport NN cord-028721-x6f26ahr 2524 1 Normally normally RB cord-028721-x6f26ahr 2524 2 , , , cord-028721-x6f26ahr 2524 3 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2524 4 detach detach VBP cord-028721-x6f26ahr 2524 5 from from IN cord-028721-x6f26ahr 2524 6 the the DT cord-028721-x6f26ahr 2524 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 2524 8 cells cell NNS cord-028721-x6f26ahr 2524 9 and and CC cord-028721-x6f26ahr 2524 10 are be VBP cord-028721-x6f26ahr 2524 11 transported transport VBN cord-028721-x6f26ahr 2524 12 through through IN cord-028721-x6f26ahr 2524 13 the the DT cord-028721-x6f26ahr 2524 14 intratesticular intratesticular JJ cord-028721-x6f26ahr 2524 15 and and CC cord-028721-x6f26ahr 2524 16 extratesticular extratesticular JJ cord-028721-x6f26ahr 2524 17 excretory excretory JJ cord-028721-x6f26ahr 2524 18 ducts duct NNS cord-028721-x6f26ahr 2524 19 , , , cord-028721-x6f26ahr 2524 20 where where WRB cord-028721-x6f26ahr 2524 21 they -PRON- PRP cord-028721-x6f26ahr 2524 22 are be VBP cord-028721-x6f26ahr 2524 23 stored store VBN cord-028721-x6f26ahr 2524 24 , , , cord-028721-x6f26ahr 2524 25 mainly mainly RB cord-028721-x6f26ahr 2524 26 in in IN cord-028721-x6f26ahr 2524 27 the the DT cord-028721-x6f26ahr 2524 28 cauda cauda NN cord-028721-x6f26ahr 2524 29 of of IN cord-028721-x6f26ahr 2524 30 the the DT cord-028721-x6f26ahr 2524 31 epididymis epididymis NN cord-028721-x6f26ahr 2524 32 , , , cord-028721-x6f26ahr 2524 33 and and CC cord-028721-x6f26ahr 2524 34 fi fi NNP cord-028721-x6f26ahr 2524 35 nally nally RB cord-028721-x6f26ahr 2524 36 released release VBN cord-028721-x6f26ahr 2524 37 from from IN cord-028721-x6f26ahr 2524 38 the the DT cord-028721-x6f26ahr 2524 39 corpus corpus NN cord-028721-x6f26ahr 2524 40 by by IN cord-028721-x6f26ahr 2524 41 ejaculation ejaculation NN cord-028721-x6f26ahr 2524 42 or or CC cord-028721-x6f26ahr 2524 43 eliminated eliminate VBN cord-028721-x6f26ahr 2524 44 by by IN cord-028721-x6f26ahr 2524 45 phagocytosis phagocytosis NN cord-028721-x6f26ahr 2524 46 . . . cord-028721-x6f26ahr 2525 1 Only only RB cord-028721-x6f26ahr 2525 2 about about IN cord-028721-x6f26ahr 2525 3 50 50 CD cord-028721-x6f26ahr 2525 4 % % NN cord-028721-x6f26ahr 2525 5 of of IN cord-028721-x6f26ahr 2525 6 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2525 7 are be VBP cord-028721-x6f26ahr 2525 8 ejaculated ejaculate VBN cord-028721-x6f26ahr 2525 9 . . . cord-028721-x6f26ahr 2526 1 Whereas whereas IN cord-028721-x6f26ahr 2526 2 the the DT cord-028721-x6f26ahr 2526 3 release release NN cord-028721-x6f26ahr 2526 4 of of IN cord-028721-x6f26ahr 2526 5 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 2526 6 from from IN cord-028721-x6f26ahr 2526 7 the the DT cord-028721-x6f26ahr 2526 8 corpus corpus NN cord-028721-x6f26ahr 2526 9 is be VBZ cord-028721-x6f26ahr 2526 10 intermittent intermittent JJ cord-028721-x6f26ahr 2526 11 , , , cord-028721-x6f26ahr 2526 12 their -PRON- PRP$ cord-028721-x6f26ahr 2526 13 transport transport NN cord-028721-x6f26ahr 2526 14 through through IN cord-028721-x6f26ahr 2526 15 the the DT cord-028721-x6f26ahr 2526 16 sperm sperm NN cord-028721-x6f26ahr 2526 17 excretory excretory JJ cord-028721-x6f26ahr 2526 18 ducts duct NNS cord-028721-x6f26ahr 2526 19 is be VBZ cord-028721-x6f26ahr 2526 20 continuous continuous JJ cord-028721-x6f26ahr 2526 21 . . . cord-028721-x6f26ahr 2527 1 Transport transport NN cord-028721-x6f26ahr 2527 2 is be VBZ cord-028721-x6f26ahr 2527 3 accomplished accomplish VBN cord-028721-x6f26ahr 2527 4 by by IN cord-028721-x6f26ahr 2527 5 the the DT cord-028721-x6f26ahr 2527 6 myofi myofi NNP cord-028721-x6f26ahr 2527 7 broblasts broblasts NNP cord-028721-x6f26ahr 2527 8 in in IN cord-028721-x6f26ahr 2527 9 the the DT cord-028721-x6f26ahr 2527 10 wall wall NN cord-028721-x6f26ahr 2527 11 of of IN cord-028721-x6f26ahr 2527 12 the the DT cord-028721-x6f26ahr 2527 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2527 14 tubules tubule NNS cord-028721-x6f26ahr 2527 15 and and CC cord-028721-x6f26ahr 2527 16 ductuli ductuli NNP cord-028721-x6f26ahr 2527 17 efferentes efferentes NNPS cord-028721-x6f26ahr 2527 18 and and CC cord-028721-x6f26ahr 2527 19 the the DT cord-028721-x6f26ahr 2527 20 smooth smooth JJ cord-028721-x6f26ahr 2527 21 muscle muscle NN cord-028721-x6f26ahr 2527 22 cells cell NNS cord-028721-x6f26ahr 2527 23 in in IN cord-028721-x6f26ahr 2527 24 the the DT cord-028721-x6f26ahr 2527 25 wall wall NN cord-028721-x6f26ahr 2527 26 of of IN cord-028721-x6f26ahr 2527 27 the the DT cord-028721-x6f26ahr 2527 28 ductus ductus NNP cord-028721-x6f26ahr 2527 29 epididymidis epididymidis NNP cord-028721-x6f26ahr 2527 30 and and CC cord-028721-x6f26ahr 2527 31 vas vas NNP cord-028721-x6f26ahr 2527 32 deferens deferens NNP cord-028721-x6f26ahr 2527 33 . . . cord-028721-x6f26ahr 2528 1 These these DT cord-028721-x6f26ahr 2528 2 cells cell NNS cord-028721-x6f26ahr 2528 3 cause cause VBP cord-028721-x6f26ahr 2528 4 peristaltic peristaltic JJ cord-028721-x6f26ahr 2528 5 contraction contraction NN cord-028721-x6f26ahr 2528 6 , , , cord-028721-x6f26ahr 2528 7 propelling propel VBG cord-028721-x6f26ahr 2528 8 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2528 9 along along IN cord-028721-x6f26ahr 2528 10 the the DT cord-028721-x6f26ahr 2528 11 length length NN cord-028721-x6f26ahr 2528 12 of of IN cord-028721-x6f26ahr 2528 13 the the DT cord-028721-x6f26ahr 2528 14 epididymis epididymis NN cord-028721-x6f26ahr 2528 15 in in IN cord-028721-x6f26ahr 2528 16 a a DT cord-028721-x6f26ahr 2528 17 mean mean NN cord-028721-x6f26ahr 2528 18 of of IN cord-028721-x6f26ahr 2528 19 12 12 CD cord-028721-x6f26ahr 2528 20 days day NNS cord-028721-x6f26ahr 2528 21 ( ( -LRB- cord-028721-x6f26ahr 2528 22 range range NN cord-028721-x6f26ahr 2528 23 , , , cord-028721-x6f26ahr 2528 24 1 1 CD cord-028721-x6f26ahr 2528 25 - - SYM cord-028721-x6f26ahr 2528 26 21 21 CD cord-028721-x6f26ahr 2528 27 days day NNS cord-028721-x6f26ahr 2528 28 ) ) -RRB- cord-028721-x6f26ahr 2528 29 . . . cord-028721-x6f26ahr 2529 1 The the DT cord-028721-x6f26ahr 2529 2 walls wall NNS cord-028721-x6f26ahr 2529 3 of of IN cord-028721-x6f26ahr 2529 4 the the DT cord-028721-x6f26ahr 2529 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 2529 6 tubules tubule NNS cord-028721-x6f26ahr 2529 7 and and CC cord-028721-x6f26ahr 2529 8 extratesticular extratesticular JJ cord-028721-x6f26ahr 2529 9 excretory excretory JJ cord-028721-x6f26ahr 2529 10 ducts duct NNS cord-028721-x6f26ahr 2529 11 are be VBP cord-028721-x6f26ahr 2529 12 under under IN cord-028721-x6f26ahr 2529 13 hormonal hormonal JJ cord-028721-x6f26ahr 2529 14 and and CC cord-028721-x6f26ahr 2529 15 neural neural JJ cord-028721-x6f26ahr 2529 16 control control NN cord-028721-x6f26ahr 2529 17 . . . cord-028721-x6f26ahr 2530 1 The the DT cord-028721-x6f26ahr 2530 2 myofi myofi JJ cord-028721-x6f26ahr 2530 3 broblasts broblast NNS cord-028721-x6f26ahr 2530 4 in in IN cord-028721-x6f26ahr 2530 5 the the DT cord-028721-x6f26ahr 2530 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 2530 7 tubules tubule NNS cord-028721-x6f26ahr 2530 8 have have VBP cord-028721-x6f26ahr 2530 9 oxytocinic oxytocinic NNP cord-028721-x6f26ahr 2530 10 , , , cord-028721-x6f26ahr 2530 11 α α NN cord-028721-x6f26ahr 2530 12 1 1 CD cord-028721-x6f26ahr 2530 13 -β -β JJS cord-028721-x6f26ahr 2530 14 - - HYPH cord-028721-x6f26ahr 2530 15 adrenergic adrenergic NN cord-028721-x6f26ahr 2530 16 , , , cord-028721-x6f26ahr 2530 17 and and CC cord-028721-x6f26ahr 2530 18 muscarinic muscarinic JJ cord-028721-x6f26ahr 2530 19 receptors receptor NNS cord-028721-x6f26ahr 2530 20 . . . cord-028721-x6f26ahr 2531 1 Unmyelinated unmyelinated JJ cord-028721-x6f26ahr 2531 2 nerve nerve NN cord-028721-x6f26ahr 2531 3 fi fi NN cord-028721-x6f26ahr 2531 4 bers ber NNS cord-028721-x6f26ahr 2531 5 penetrate penetrate VB cord-028721-x6f26ahr 2531 6 the the DT cord-028721-x6f26ahr 2531 7 tubular tubular JJ cord-028721-x6f26ahr 2531 8 lamina lamina NN cord-028721-x6f26ahr 2531 9 propria propria NN cord-028721-x6f26ahr 2531 10 , , , cord-028721-x6f26ahr 2531 11 pass pass VB cord-028721-x6f26ahr 2531 12 among among IN cord-028721-x6f26ahr 2531 13 the the DT cord-028721-x6f26ahr 2531 14 myofi myofi NNP cord-028721-x6f26ahr 2531 15 broblasts broblasts NNP cord-028721-x6f26ahr 2531 16 , , , cord-028721-x6f26ahr 2531 17 and and CC cord-028721-x6f26ahr 2531 18 end end VB cord-028721-x6f26ahr 2531 19 near near IN cord-028721-x6f26ahr 2531 20 the the DT cord-028721-x6f26ahr 2531 21 Sertoli Sertoli NNP cord-028721-x6f26ahr 2531 22 cells cell NNS cord-028721-x6f26ahr 2531 23 . . . cord-028721-x6f26ahr 2532 1 1075 1075 CD cord-028721-x6f26ahr 2533 1 Along along IN cord-028721-x6f26ahr 2533 2 their -PRON- PRP$ cord-028721-x6f26ahr 2533 3 length length NN cord-028721-x6f26ahr 2533 4 these these DT cord-028721-x6f26ahr 2533 5 nerve nerve NN cord-028721-x6f26ahr 2533 6 fi fi NN cord-028721-x6f26ahr 2533 7 bers ber NNS cord-028721-x6f26ahr 2533 8 have have VBP cord-028721-x6f26ahr 2533 9 varicosities varicosity NNS cord-028721-x6f26ahr 2533 10 containing contain VBG cord-028721-x6f26ahr 2533 11 sympathetic sympathetic JJ cord-028721-x6f26ahr 2533 12 vesicles vesicle NNS cord-028721-x6f26ahr 2533 13 . . . cord-028721-x6f26ahr 2534 1 The the DT cord-028721-x6f26ahr 2534 2 ductus ductus NN cord-028721-x6f26ahr 2534 3 epididymis epididymis NN cord-028721-x6f26ahr 2534 4 is be VBZ cord-028721-x6f26ahr 2534 5 innervated innervate VBN cord-028721-x6f26ahr 2534 6 by by IN cord-028721-x6f26ahr 2534 7 sympathetic sympathetic JJ cord-028721-x6f26ahr 2534 8 adrenergic adrenergic JJ cord-028721-x6f26ahr 2534 9 nerve nerve NN cord-028721-x6f26ahr 2534 10 fi fi NN cord-028721-x6f26ahr 2534 11 bers ber NNS cord-028721-x6f26ahr 2534 12 that that DT cord-028721-x6f26ahr 2534 13 end end NN cord-028721-x6f26ahr 2534 14 among among IN cord-028721-x6f26ahr 2534 15 the the DT cord-028721-x6f26ahr 2534 16 smooth smooth JJ cord-028721-x6f26ahr 2534 17 muscle muscle NN cord-028721-x6f26ahr 2534 18 cells cell NNS cord-028721-x6f26ahr 2534 19 . . . cord-028721-x6f26ahr 2535 1 Several several JJ cord-028721-x6f26ahr 2535 2 hormones hormone NNS cord-028721-x6f26ahr 2535 3 , , , cord-028721-x6f26ahr 2535 4 including include VBG cord-028721-x6f26ahr 2535 5 oxytocin oxytocin NN cord-028721-x6f26ahr 2535 6 , , , cord-028721-x6f26ahr 2535 7 endothelin-1 endothelin-1 NNP cord-028721-x6f26ahr 2535 8 , , , cord-028721-x6f26ahr 2535 9 vasopressin vasopressin NN cord-028721-x6f26ahr 2535 10 , , , cord-028721-x6f26ahr 2535 11 and and CC cord-028721-x6f26ahr 2535 12 prostaglandins prostaglandin NNS cord-028721-x6f26ahr 2535 13 , , , cord-028721-x6f26ahr 2535 14 act act VB cord-028721-x6f26ahr 2535 15 on on IN cord-028721-x6f26ahr 2535 16 the the DT cord-028721-x6f26ahr 2535 17 musculature musculature NN cord-028721-x6f26ahr 2535 18 of of IN cord-028721-x6f26ahr 2535 19 the the DT cord-028721-x6f26ahr 2535 20 ductus ductus NN cord-028721-x6f26ahr 2535 21 epididymis epididymis NN cord-028721-x6f26ahr 2535 22 . . . cord-028721-x6f26ahr 2536 1 The the DT cord-028721-x6f26ahr 2536 2 peristaltic peristaltic JJ cord-028721-x6f26ahr 2536 3 contractions contraction NNS cord-028721-x6f26ahr 2536 4 begin begin VBP cord-028721-x6f26ahr 2536 5 in in IN cord-028721-x6f26ahr 2536 6 the the DT cord-028721-x6f26ahr 2536 7 caput caput NN cord-028721-x6f26ahr 2536 8 and and CC cord-028721-x6f26ahr 2536 9 propagate propagate VB cord-028721-x6f26ahr 2536 10 toward toward IN cord-028721-x6f26ahr 2536 11 the the DT cord-028721-x6f26ahr 2536 12 cauda cauda NN cord-028721-x6f26ahr 2536 13 . . . cord-028721-x6f26ahr 2537 1 The the DT cord-028721-x6f26ahr 2537 2 frequency frequency NN cord-028721-x6f26ahr 2537 3 and and CC cord-028721-x6f26ahr 2537 4 amplitude amplitude NN cord-028721-x6f26ahr 2537 5 of of IN cord-028721-x6f26ahr 2537 6 contractions contraction NNS cord-028721-x6f26ahr 2537 7 vary vary VBP cord-028721-x6f26ahr 2537 8 from from IN cord-028721-x6f26ahr 2537 9 region region NN cord-028721-x6f26ahr 2537 10 to to IN cord-028721-x6f26ahr 2537 11 region region NN cord-028721-x6f26ahr 2537 12 , , , cord-028721-x6f26ahr 2537 13 being be VBG cord-028721-x6f26ahr 2537 14 higher high JJR cord-028721-x6f26ahr 2537 15 in in IN cord-028721-x6f26ahr 2537 16 frequency frequency NN cord-028721-x6f26ahr 2537 17 near near IN cord-028721-x6f26ahr 2537 18 the the DT cord-028721-x6f26ahr 2537 19 caput caput NN cord-028721-x6f26ahr 2537 20 and and CC cord-028721-x6f26ahr 2537 21 of of IN cord-028721-x6f26ahr 2537 22 maximal maximal JJ cord-028721-x6f26ahr 2537 23 amplitude amplitude NN cord-028721-x6f26ahr 2537 24 in in IN cord-028721-x6f26ahr 2537 25 the the DT cord-028721-x6f26ahr 2537 26 initial initial JJ cord-028721-x6f26ahr 2537 27 portion portion NN cord-028721-x6f26ahr 2537 28 of of IN cord-028721-x6f26ahr 2537 29 the the DT cord-028721-x6f26ahr 2537 30 cauda cauda NN cord-028721-x6f26ahr 2537 31 . . . cord-028721-x6f26ahr 2538 1 The the DT cord-028721-x6f26ahr 2538 2 progressive progressive JJ cord-028721-x6f26ahr 2538 3 increase increase NN cord-028721-x6f26ahr 2538 4 in in IN cord-028721-x6f26ahr 2538 5 amplitude amplitude NN cord-028721-x6f26ahr 2538 6 parallels parallel VBZ cord-028721-x6f26ahr 2538 7 the the DT cord-028721-x6f26ahr 2538 8 progressive progressive JJ cord-028721-x6f26ahr 2538 9 increase increase NN cord-028721-x6f26ahr 2538 10 in in IN cord-028721-x6f26ahr 2538 11 thickness thickness NN cord-028721-x6f26ahr 2538 12 of of IN cord-028721-x6f26ahr 2538 13 the the DT cord-028721-x6f26ahr 2538 14 muscular muscular JJ cord-028721-x6f26ahr 2538 15 wall wall NN cord-028721-x6f26ahr 2538 16 and and CC cord-028721-x6f26ahr 2538 17 the the DT cord-028721-x6f26ahr 2538 18 requirement requirement NN cord-028721-x6f26ahr 2538 19 for for IN cord-028721-x6f26ahr 2538 20 greater great JJR cord-028721-x6f26ahr 2538 21 force force NN cord-028721-x6f26ahr 2538 22 to to TO cord-028721-x6f26ahr 2538 23 propel propel VB cord-028721-x6f26ahr 2538 24 the the DT cord-028721-x6f26ahr 2538 25 fl fl NNP cord-028721-x6f26ahr 2538 26 uid uid NN cord-028721-x6f26ahr 2538 27 as as IN cord-028721-x6f26ahr 2538 28 it -PRON- PRP cord-028721-x6f26ahr 2538 29 becomes become VBZ cord-028721-x6f26ahr 2538 30 progressively progressively RB cord-028721-x6f26ahr 2538 31 more more RBR cord-028721-x6f26ahr 2538 32 viscous viscous JJ cord-028721-x6f26ahr 2538 33 with with IN cord-028721-x6f26ahr 2538 34 a a DT cord-028721-x6f26ahr 2538 35 higher high JJR cord-028721-x6f26ahr 2538 36 concentration concentration NN cord-028721-x6f26ahr 2538 37 of of IN cord-028721-x6f26ahr 2538 38 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2538 39 . . . cord-028721-x6f26ahr 2539 1 The the DT cord-028721-x6f26ahr 2539 2 distal distal JJ cord-028721-x6f26ahr 2539 3 portion portion NN cord-028721-x6f26ahr 2539 4 of of IN cord-028721-x6f26ahr 2539 5 the the DT cord-028721-x6f26ahr 2539 6 cauda cauda NN cord-028721-x6f26ahr 2539 7 is be VBZ cord-028721-x6f26ahr 2539 8 unusually unusually RB cord-028721-x6f26ahr 2539 9 at at IN cord-028721-x6f26ahr 2539 10 rest rest NN cord-028721-x6f26ahr 2539 11 because because IN cord-028721-x6f26ahr 2539 12 it -PRON- PRP cord-028721-x6f26ahr 2539 13 is be VBZ cord-028721-x6f26ahr 2539 14 the the DT cord-028721-x6f26ahr 2539 15 main main JJ cord-028721-x6f26ahr 2539 16 reservoir reservoir NN cord-028721-x6f26ahr 2539 17 of of IN cord-028721-x6f26ahr 2539 18 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2539 19 between between IN cord-028721-x6f26ahr 2539 20 ejaculations ejaculation NNS cord-028721-x6f26ahr 2539 21 . . . cord-028721-x6f26ahr 2540 1 Several several JJ cord-028721-x6f26ahr 2540 2 times time NNS cord-028721-x6f26ahr 2540 3 daily daily JJ cord-028721-x6f26ahr 2540 4 , , , cord-028721-x6f26ahr 2540 5 vigorous vigorous JJ cord-028721-x6f26ahr 2540 6 contractions contraction NNS cord-028721-x6f26ahr 2540 7 of of IN cord-028721-x6f26ahr 2540 8 the the DT cord-028721-x6f26ahr 2540 9 distal distal JJ cord-028721-x6f26ahr 2540 10 cauda cauda NN cord-028721-x6f26ahr 2540 11 impel impel VBP cord-028721-x6f26ahr 2540 12 the the DT cord-028721-x6f26ahr 2540 13 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2540 14 from from IN cord-028721-x6f26ahr 2540 15 the the DT cord-028721-x6f26ahr 2540 16 cauda cauda NN cord-028721-x6f26ahr 2540 17 toward toward IN cord-028721-x6f26ahr 2540 18 the the DT cord-028721-x6f26ahr 2540 19 vas vas NNP cord-028721-x6f26ahr 2540 20 deferens deferen NNS cord-028721-x6f26ahr 2540 21 . . . cord-028721-x6f26ahr 2541 1 1076 1076 CD cord-028721-x6f26ahr 2542 1 Several several JJ cord-028721-x6f26ahr 2542 2 drugs drug NNS cord-028721-x6f26ahr 2542 3 that that WDT cord-028721-x6f26ahr 2542 4 favor favor VBP cord-028721-x6f26ahr 2542 5 contraction contraction NN cord-028721-x6f26ahr 2542 6 of of IN cord-028721-x6f26ahr 2542 7 the the DT cord-028721-x6f26ahr 2542 8 muscular muscular JJ cord-028721-x6f26ahr 2542 9 wall wall NN cord-028721-x6f26ahr 2542 10 ( ( -LRB- cord-028721-x6f26ahr 2542 11 α α NN cord-028721-x6f26ahr 2542 12 1 1 CD cord-028721-x6f26ahr 2542 13 blocking blocking NN cord-028721-x6f26ahr 2542 14 and and CC cord-028721-x6f26ahr 2542 15 F F NNP cord-028721-x6f26ahr 2542 16 2α 2α CD cord-028721-x6f26ahr 2542 17 prostaglandins prostaglandin NNS cord-028721-x6f26ahr 2542 18 ) ) -RRB- cord-028721-x6f26ahr 2542 19 have have VBP cord-028721-x6f26ahr 2542 20 been be VBN cord-028721-x6f26ahr 2542 21 successfully successfully RB cord-028721-x6f26ahr 2542 22 used use VBN cord-028721-x6f26ahr 2542 23 in in IN cord-028721-x6f26ahr 2542 24 the the DT cord-028721-x6f26ahr 2542 25 treatment treatment NN cord-028721-x6f26ahr 2542 26 of of IN cord-028721-x6f26ahr 2542 27 alterations alteration NNS cord-028721-x6f26ahr 2542 28 in in IN cord-028721-x6f26ahr 2542 29 the the DT cord-028721-x6f26ahr 2542 30 spermatozoon spermatozoon NN cord-028721-x6f26ahr 2542 31 transport transport NN cord-028721-x6f26ahr 2542 32 . . . cord-028721-x6f26ahr 2543 1 1077 1077 CD cord-028721-x6f26ahr 2543 2 Knowledge knowledge NN cord-028721-x6f26ahr 2543 3 of of IN cord-028721-x6f26ahr 2543 4 the the DT cord-028721-x6f26ahr 2543 5 incidence incidence NN cord-028721-x6f26ahr 2543 6 of of IN cord-028721-x6f26ahr 2543 7 chromosomal chromosomal JJ cord-028721-x6f26ahr 2543 8 abnormalities abnormality NNS cord-028721-x6f26ahr 2543 9 in in IN cord-028721-x6f26ahr 2543 10 male male JJ cord-028721-x6f26ahr 2543 11 infertility infertility NN cord-028721-x6f26ahr 2543 12 has have VBZ cord-028721-x6f26ahr 2543 13 progressed progress VBN cord-028721-x6f26ahr 2543 14 in in IN cord-028721-x6f26ahr 2543 15 parallel parallel NN cord-028721-x6f26ahr 2543 16 with with IN cord-028721-x6f26ahr 2543 17 advances advance NNS cord-028721-x6f26ahr 2543 18 in in IN cord-028721-x6f26ahr 2543 19 technology technology NN cord-028721-x6f26ahr 2543 20 : : : cord-028721-x6f26ahr 2543 21 karyotypic karyotypic NNP cord-028721-x6f26ahr 2543 22 studies study NNS cord-028721-x6f26ahr 2543 23 in in IN cord-028721-x6f26ahr 2543 24 peripheral peripheral JJ cord-028721-x6f26ahr 2543 25 blood blood NN cord-028721-x6f26ahr 2543 26 , , , cord-028721-x6f26ahr 2543 27 meiotic meiotic JJ cord-028721-x6f26ahr 2543 28 and and CC cord-028721-x6f26ahr 2543 29 chromosomal chromosomal JJ cord-028721-x6f26ahr 2543 30 studies study NNS cord-028721-x6f26ahr 2543 31 of of IN cord-028721-x6f26ahr 2543 32 testicular testicular JJ cord-028721-x6f26ahr 2543 33 biopsies biopsy NNS cord-028721-x6f26ahr 2543 34 , , , cord-028721-x6f26ahr 2543 35 analysis analysis NN cord-028721-x6f26ahr 2543 36 of of IN cord-028721-x6f26ahr 2543 37 chromosomes chromosome NNS cord-028721-x6f26ahr 2543 38 in in IN cord-028721-x6f26ahr 2543 39 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2543 40 , , , cord-028721-x6f26ahr 2543 41 and and CC cord-028721-x6f26ahr 2543 42 analysis analysis NN cord-028721-x6f26ahr 2543 43 of of IN cord-028721-x6f26ahr 2543 44 DNA dna NN cord-028721-x6f26ahr 2543 45 in in IN cord-028721-x6f26ahr 2543 46 blood blood NN cord-028721-x6f26ahr 2543 47 and and CC cord-028721-x6f26ahr 2543 48 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2543 49 for for IN cord-028721-x6f26ahr 2543 50 the the DT cord-028721-x6f26ahr 2543 51 detection detection NN cord-028721-x6f26ahr 2543 52 of of IN cord-028721-x6f26ahr 2543 53 chromosome chromosome NN cord-028721-x6f26ahr 2543 54 Y Y NNP cord-028721-x6f26ahr 2543 55 deletions deletion NNS cord-028721-x6f26ahr 2543 56 . . . cord-028721-x6f26ahr 2544 1 1078 1078 CD cord-028721-x6f26ahr 2545 1 The the DT cord-028721-x6f26ahr 2545 2 incidence incidence NN cord-028721-x6f26ahr 2545 3 of of IN cord-028721-x6f26ahr 2545 4 chromosomal chromosomal JJ cord-028721-x6f26ahr 2545 5 anomalies anomaly NNS cord-028721-x6f26ahr 2545 6 in in IN cord-028721-x6f26ahr 2545 7 infertile infertile JJ cord-028721-x6f26ahr 2545 8 men man NNS cord-028721-x6f26ahr 2545 9 is be VBZ cord-028721-x6f26ahr 2545 10 2.2 2.2 CD cord-028721-x6f26ahr 2545 11 - - SYM cord-028721-x6f26ahr 2545 12 6.6 6.6 CD cord-028721-x6f26ahr 2545 13 % % NN cord-028721-x6f26ahr 2545 14 , , , cord-028721-x6f26ahr 2545 15 whereas whereas IN cord-028721-x6f26ahr 2545 16 in in IN cord-028721-x6f26ahr 2545 17 the the DT cord-028721-x6f26ahr 2545 18 general general JJ cord-028721-x6f26ahr 2545 19 population population NN cord-028721-x6f26ahr 2545 20 it -PRON- PRP cord-028721-x6f26ahr 2545 21 is be VBZ cord-028721-x6f26ahr 2545 22 lower low JJR cord-028721-x6f26ahr 2545 23 than than IN cord-028721-x6f26ahr 2545 24 0.5 0.5 CD cord-028721-x6f26ahr 2545 25 % % NN cord-028721-x6f26ahr 2545 26 . . . cord-028721-x6f26ahr 2546 1 The the DT cord-028721-x6f26ahr 2546 2 frequency frequency NN cord-028721-x6f26ahr 2546 3 of of IN cord-028721-x6f26ahr 2546 4 chromosomal chromosomal JJ cord-028721-x6f26ahr 2546 5 abnormalities abnormality NNS cord-028721-x6f26ahr 2546 6 increases increase VBZ cord-028721-x6f26ahr 2546 7 with with IN cord-028721-x6f26ahr 2546 8 the the DT cord-028721-x6f26ahr 2546 9 decrease decrease NN cord-028721-x6f26ahr 2546 10 in in IN cord-028721-x6f26ahr 2546 11 number number NN cord-028721-x6f26ahr 2546 12 of of IN cord-028721-x6f26ahr 2546 13 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2546 14 in in IN cord-028721-x6f26ahr 2546 15 the the DT cord-028721-x6f26ahr 2546 16 ejaculate ejaculate NN cord-028721-x6f26ahr 2546 17 . . . cord-028721-x6f26ahr 2547 1 1079 1079 CD cord-028721-x6f26ahr 2548 1 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2548 2 's 's POS cord-028721-x6f26ahr 2548 3 syndrome syndrome NN cord-028721-x6f26ahr 2548 4 Genetic genetic JJ cord-028721-x6f26ahr 2548 5 and and CC cord-028721-x6f26ahr 2548 6 clinical clinical JJ cord-028721-x6f26ahr 2548 7 aspects aspect NNS cord-028721-x6f26ahr 2548 8 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2548 9 's 's POS cord-028721-x6f26ahr 2548 10 syndrome syndrome NN cord-028721-x6f26ahr 2548 11 is be VBZ cord-028721-x6f26ahr 2548 12 characterized characterize VBN cord-028721-x6f26ahr 2548 13 by by IN cord-028721-x6f26ahr 2548 14 an an DT cord-028721-x6f26ahr 2548 15 abnormal abnormal JJ cord-028721-x6f26ahr 2548 16 number number NN cord-028721-x6f26ahr 2548 17 of of IN cord-028721-x6f26ahr 2548 18 X x NN cord-028721-x6f26ahr 2548 19 chromosomes chromosome NNS cord-028721-x6f26ahr 2548 20 and and CC cord-028721-x6f26ahr 2548 21 primary primary JJ cord-028721-x6f26ahr 2548 22 gonadal gonadal NNP cord-028721-x6f26ahr 2548 23 insuffi insuffi NNP cord-028721-x6f26ahr 2548 24 ciency ciency NNP cord-028721-x6f26ahr 2548 25 . . . cord-028721-x6f26ahr 2549 1 The the DT cord-028721-x6f26ahr 2549 2 original original JJ cord-028721-x6f26ahr 2549 3 description description NN cord-028721-x6f26ahr 2549 4 was be VBD cord-028721-x6f26ahr 2549 5 of of IN cord-028721-x6f26ahr 2549 6 a a DT cord-028721-x6f26ahr 2549 7 man man NN cord-028721-x6f26ahr 2549 8 with with IN cord-028721-x6f26ahr 2549 9 eunuchoidism eunuchoidism NN cord-028721-x6f26ahr 2549 10 , , , cord-028721-x6f26ahr 2549 11 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2549 12 , , , cord-028721-x6f26ahr 2549 13 small small JJ cord-028721-x6f26ahr 2549 14 testes testis NNS cord-028721-x6f26ahr 2549 15 , , , cord-028721-x6f26ahr 2549 16 mental mental JJ cord-028721-x6f26ahr 2549 17 retardation retardation NN cord-028721-x6f26ahr 2549 18 , , , cord-028721-x6f26ahr 2549 19 and and CC cord-028721-x6f26ahr 2549 20 elevated elevated JJ cord-028721-x6f26ahr 2549 21 level level NN cord-028721-x6f26ahr 2549 22 of of IN cord-028721-x6f26ahr 2549 23 serum serum NN cord-028721-x6f26ahr 2549 24 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 2549 25 . . . cord-028721-x6f26ahr 2550 1 1080 1080 CD cord-028721-x6f26ahr 2551 1 The the DT cord-028721-x6f26ahr 2551 2 frequency frequency NN cord-028721-x6f26ahr 2551 3 of of IN cord-028721-x6f26ahr 2551 4 this this DT cord-028721-x6f26ahr 2551 5 syndrome syndrome NN cord-028721-x6f26ahr 2551 6 varies vary VBZ cord-028721-x6f26ahr 2551 7 according accord VBG cord-028721-x6f26ahr 2551 8 to to IN cord-028721-x6f26ahr 2551 9 the the DT cord-028721-x6f26ahr 2551 10 population population NN cord-028721-x6f26ahr 2551 11 studied study VBD cord-028721-x6f26ahr 2551 12 : : : cord-028721-x6f26ahr 2551 13 1 1 CD cord-028721-x6f26ahr 2551 14 in in IN cord-028721-x6f26ahr 2551 15 1000 1000 CD cord-028721-x6f26ahr 2551 16 to to IN cord-028721-x6f26ahr 2551 17 1 1 CD cord-028721-x6f26ahr 2551 18 in in IN cord-028721-x6f26ahr 2551 19 1400 1400 CD cord-028721-x6f26ahr 2551 20 surviving survive VBG cord-028721-x6f26ahr 2551 21 newborns newborn NNS cord-028721-x6f26ahr 2551 22 ; ; : cord-028721-x6f26ahr 2551 23 1 1 CD cord-028721-x6f26ahr 2551 24 in in IN cord-028721-x6f26ahr 2551 25 100 100 CD cord-028721-x6f26ahr 2551 26 patients patient NNS cord-028721-x6f26ahr 2551 27 in in IN cord-028721-x6f26ahr 2551 28 mental mental JJ cord-028721-x6f26ahr 2551 29 institution institution NN cord-028721-x6f26ahr 2551 30 ; ; : cord-028721-x6f26ahr 2551 31 3.4 3.4 CD cord-028721-x6f26ahr 2551 32 in in IN cord-028721-x6f26ahr 2551 33 100 100 CD cord-028721-x6f26ahr 2551 34 infertile infertile JJ cord-028721-x6f26ahr 2551 35 men man NNS cord-028721-x6f26ahr 2551 36 ; ; : cord-028721-x6f26ahr 2551 37 and and CC cord-028721-x6f26ahr 2551 38 11 11 CD cord-028721-x6f26ahr 2551 39 % % NN cord-028721-x6f26ahr 2551 40 of of IN cord-028721-x6f26ahr 2551 41 patients patient NNS cord-028721-x6f26ahr 2551 42 who who WP cord-028721-x6f26ahr 2551 43 are be VBP cord-028721-x6f26ahr 2551 44 azoospermic azoospermic JJ cord-028721-x6f26ahr 2551 45 . . . cord-028721-x6f26ahr 2552 1 1081 1081 CD cord-028721-x6f26ahr 2553 1 In in IN cord-028721-x6f26ahr 2553 2 80 80 CD cord-028721-x6f26ahr 2553 3 % % NN cord-028721-x6f26ahr 2553 4 of of IN cord-028721-x6f26ahr 2553 5 cases case NNS cord-028721-x6f26ahr 2553 6 , , , cord-028721-x6f26ahr 2553 7 the the DT cord-028721-x6f26ahr 2553 8 karyotype karyotype NN cord-028721-x6f26ahr 2553 9 is be VBZ cord-028721-x6f26ahr 2553 10 47XXY 47xxy JJ cord-028721-x6f26ahr 2553 11 . . . cord-028721-x6f26ahr 2554 1 The the DT cord-028721-x6f26ahr 2554 2 remaining remain VBG cord-028721-x6f26ahr 2554 3 20 20 CD cord-028721-x6f26ahr 2554 4 % % NN cord-028721-x6f26ahr 2554 5 have have VBP cord-028721-x6f26ahr 2554 6 chromosomal chromosomal JJ cord-028721-x6f26ahr 2554 7 mosaicism mosaicism NN cord-028721-x6f26ahr 2554 8 with with IN cord-028721-x6f26ahr 2554 9 at at RB cord-028721-x6f26ahr 2554 10 least least JJS cord-028721-x6f26ahr 2554 11 two two CD cord-028721-x6f26ahr 2554 12 X x NN cord-028721-x6f26ahr 2554 13 chromosomes chromosome NNS cord-028721-x6f26ahr 2554 14 . . . cord-028721-x6f26ahr 2555 1 The the DT cord-028721-x6f26ahr 2555 2 most most RBS cord-028721-x6f26ahr 2555 3 common common JJ cord-028721-x6f26ahr 2555 4 are be VBP cord-028721-x6f26ahr 2555 5 XY XY NNP cord-028721-x6f26ahr 2555 6 / / SYM cord-028721-x6f26ahr 2555 7 XXY XXY NNP cord-028721-x6f26ahr 2555 8 , , , cord-028721-x6f26ahr 2555 9 XY XY NNP cord-028721-x6f26ahr 2555 10 / / SYM cord-028721-x6f26ahr 2555 11 XXXY XXXY NNP cord-028721-x6f26ahr 2555 12 , , , cord-028721-x6f26ahr 2555 13 XX/ XX/ NNP cord-028721-x6f26ahr 2555 14 XXY XXY NNP cord-028721-x6f26ahr 2555 15 , , , cord-028721-x6f26ahr 2555 16 XXY XXY NNP cord-028721-x6f26ahr 2555 17 / / SYM cord-028721-x6f26ahr 2555 18 XX XX NNP cord-028721-x6f26ahr 2555 19 / / SYM cord-028721-x6f26ahr 2555 20 XY XY NNP cord-028721-x6f26ahr 2555 21 , , , cord-028721-x6f26ahr 2555 22 XY XY NNP cord-028721-x6f26ahr 2555 23 / / SYM cord-028721-x6f26ahr 2555 24 XO XO NNP cord-028721-x6f26ahr 2555 25 / / SYM cord-028721-x6f26ahr 2555 26 XXY XXY NNP cord-028721-x6f26ahr 2555 27 , , , cord-028721-x6f26ahr 2555 28 XX XX NNP cord-028721-x6f26ahr 2555 29 / / SYM cord-028721-x6f26ahr 2555 30 XXY XXY NNP cord-028721-x6f26ahr 2555 31 / / SYM cord-028721-x6f26ahr 2555 32 XXXY XXXY NNP cord-028721-x6f26ahr 2555 33 , , , cord-028721-x6f26ahr 2555 34 and and CC cord-028721-x6f26ahr 2555 35 XXXY/ XXXY/ NNP cord-028721-x6f26ahr 2555 36 XXXXY XXXXY NNP cord-028721-x6f26ahr 2555 37 . . . cord-028721-x6f26ahr 2556 1 The the DT cord-028721-x6f26ahr 2556 2 47XXY 47xxy JJ cord-028721-x6f26ahr 2556 3 lesion lesion NN cord-028721-x6f26ahr 2556 4 is be VBZ cord-028721-x6f26ahr 2556 5 due due JJ cord-028721-x6f26ahr 2556 6 to to IN cord-028721-x6f26ahr 2556 7 non non JJ cord-028721-x6f26ahr 2556 8 - - JJ cord-028721-x6f26ahr 2556 9 disjunction disjunction JJ cord-028721-x6f26ahr 2556 10 in in IN cord-028721-x6f26ahr 2556 11 sex sex NN cord-028721-x6f26ahr 2556 12 chromosome chromosome NN cord-028721-x6f26ahr 2556 13 migration migration NN cord-028721-x6f26ahr 2556 14 during during IN cord-028721-x6f26ahr 2556 15 the the DT cord-028721-x6f26ahr 2556 16 fi fi NNP cord-028721-x6f26ahr 2556 17 rst rst NN cord-028721-x6f26ahr 2556 18 or or CC cord-028721-x6f26ahr 2556 19 second second JJ cord-028721-x6f26ahr 2556 20 meiotic meiotic JJ cord-028721-x6f26ahr 2556 21 division division NN cord-028721-x6f26ahr 2556 22 of of IN cord-028721-x6f26ahr 2556 23 the the DT cord-028721-x6f26ahr 2556 24 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2556 25 or or CC cord-028721-x6f26ahr 2556 26 ovule ovule NN cord-028721-x6f26ahr 2556 27 , , , cord-028721-x6f26ahr 2556 28 or or CC cord-028721-x6f26ahr 2556 29 during during IN cord-028721-x6f26ahr 2556 30 the the DT cord-028721-x6f26ahr 2556 31 fi fi NNP cord-028721-x6f26ahr 2556 32 rst rst NNP cord-028721-x6f26ahr 2556 33 meiotic meiotic JJ cord-028721-x6f26ahr 2556 34 division division NN cord-028721-x6f26ahr 2556 35 of of IN cord-028721-x6f26ahr 2556 36 the the DT cord-028721-x6f26ahr 2556 37 zygote zygote NN cord-028721-x6f26ahr 2556 38 . . . cord-028721-x6f26ahr 2557 1 1082 1082 CD cord-028721-x6f26ahr 2557 2 Study Study NNP cord-028721-x6f26ahr 2557 3 of of IN cord-028721-x6f26ahr 2557 4 the the DT cord-028721-x6f26ahr 2557 5 Xg Xg NNP cord-028721-x6f26ahr 2557 6 antigen antigen NN cord-028721-x6f26ahr 2557 7 in in IN cord-028721-x6f26ahr 2557 8 blood blood NN cord-028721-x6f26ahr 2557 9 revealed reveal VBD cord-028721-x6f26ahr 2557 10 that that IN cord-028721-x6f26ahr 2557 11 the the DT cord-028721-x6f26ahr 2557 12 extra extra JJ cord-028721-x6f26ahr 2557 13 X x NN cord-028721-x6f26ahr 2557 14 chromosome chromosome NN cord-028721-x6f26ahr 2557 15 is be VBZ cord-028721-x6f26ahr 2557 16 from from IN cord-028721-x6f26ahr 2557 17 the the DT cord-028721-x6f26ahr 2557 18 mother mother NN cord-028721-x6f26ahr 2557 19 in in IN cord-028721-x6f26ahr 2557 20 73 73 CD cord-028721-x6f26ahr 2557 21 % % NN cord-028721-x6f26ahr 2557 22 of of IN cord-028721-x6f26ahr 2557 23 cases case NNS cord-028721-x6f26ahr 2557 24 . . . cord-028721-x6f26ahr 2558 1 Advanced advanced JJ cord-028721-x6f26ahr 2558 2 maternal maternal JJ cord-028721-x6f26ahr 2558 3 age age NN cord-028721-x6f26ahr 2558 4 increases increase VBZ cord-028721-x6f26ahr 2558 5 the the DT cord-028721-x6f26ahr 2558 6 incidence incidence NN cord-028721-x6f26ahr 2558 7 of of IN cord-028721-x6f26ahr 2558 8 children child NNS cord-028721-x6f26ahr 2558 9 with with IN cord-028721-x6f26ahr 2558 10 the the DT cord-028721-x6f26ahr 2558 11 47XXY 47xxy CD cord-028721-x6f26ahr 2558 12 karyotype karyotype NN cord-028721-x6f26ahr 2558 13 . . . cord-028721-x6f26ahr 2559 1 In in IN cord-028721-x6f26ahr 2559 2 47XXY 47xxy CD cord-028721-x6f26ahr 2559 3 patients patient NNS cord-028721-x6f26ahr 2559 4 , , , cord-028721-x6f26ahr 2559 5 the the DT cord-028721-x6f26ahr 2559 6 most most RBS cord-028721-x6f26ahr 2559 7 common common JJ cord-028721-x6f26ahr 2559 8 clinical clinical JJ cord-028721-x6f26ahr 2559 9 fi fi NN cord-028721-x6f26ahr 2559 10 ndings nding NNS cord-028721-x6f26ahr 2559 11 are be VBP cord-028721-x6f26ahr 2559 12 : : : cord-028721-x6f26ahr 2559 13 1083 1083 CD cord-028721-x6f26ahr 2560 1 • • NNP cord-028721-x6f26ahr 2561 1 Eunuchoid eunuchoid JJ cord-028721-x6f26ahr 2561 2 phenotype phenotype NN cord-028721-x6f26ahr 2561 3 with with IN cord-028721-x6f26ahr 2561 4 increased increase VBN cord-028721-x6f26ahr 2561 5 stature stature NN cord-028721-x6f26ahr 2561 6 . . . cord-028721-x6f26ahr 2562 1 The the DT cord-028721-x6f26ahr 2562 2 increased increase VBN cord-028721-x6f26ahr 2562 3 height height NN cord-028721-x6f26ahr 2562 4 is be VBZ cord-028721-x6f26ahr 2562 5 due due JJ cord-028721-x6f26ahr 2562 6 to to IN cord-028721-x6f26ahr 2562 7 a a DT cord-028721-x6f26ahr 2562 8 disproportionate disproportionate JJ cord-028721-x6f26ahr 2562 9 lengthening lengthening NN cord-028721-x6f26ahr 2562 10 of of IN cord-028721-x6f26ahr 2562 11 the the DT cord-028721-x6f26ahr 2562 12 lower low JJR cord-028721-x6f26ahr 2562 13 extremities extremity NNS cord-028721-x6f26ahr 2562 14 . . . cord-028721-x6f26ahr 2563 1 The the DT cord-028721-x6f26ahr 2563 2 ratio ratio NN cord-028721-x6f26ahr 2563 3 of of IN cord-028721-x6f26ahr 2563 4 span span NN cord-028721-x6f26ahr 2563 5 to to IN cord-028721-x6f26ahr 2563 6 height height NN cord-028721-x6f26ahr 2563 7 is be VBZ cord-028721-x6f26ahr 2563 8 less less JJR cord-028721-x6f26ahr 2563 9 than than IN cord-028721-x6f26ahr 2563 10 1 1 CD cord-028721-x6f26ahr 2563 11 . . . cord-028721-x6f26ahr 2564 1 • • NNP cord-028721-x6f26ahr 2565 1 Incomplete incomplete JJ cord-028721-x6f26ahr 2565 2 virilization virilization NN cord-028721-x6f26ahr 2565 3 . . . cord-028721-x6f26ahr 2566 1 This this DT cord-028721-x6f26ahr 2566 2 is be VBZ cord-028721-x6f26ahr 2566 3 variable variable JJ cord-028721-x6f26ahr 2566 4 and and CC cord-028721-x6f26ahr 2566 5 ranges range VBZ cord-028721-x6f26ahr 2566 6 from from IN cord-028721-x6f26ahr 2566 7 normal normal JJ cord-028721-x6f26ahr 2566 8 development development NN cord-028721-x6f26ahr 2566 9 to to IN cord-028721-x6f26ahr 2566 10 absence absence NN cord-028721-x6f26ahr 2566 11 of of IN cord-028721-x6f26ahr 2566 12 secondary secondary JJ cord-028721-x6f26ahr 2566 13 sex sex NN cord-028721-x6f26ahr 2566 14 characteristics characteristic NNS cord-028721-x6f26ahr 2566 15 . . . cord-028721-x6f26ahr 2567 1 • • NNP cord-028721-x6f26ahr 2568 1 Gynecomastia gynecomastia NN cord-028721-x6f26ahr 2568 2 , , , cord-028721-x6f26ahr 2568 3 usually usually RB cord-028721-x6f26ahr 2568 4 bilateral bilateral JJ cord-028721-x6f26ahr 2568 5 , , , cord-028721-x6f26ahr 2568 6 present present JJ cord-028721-x6f26ahr 2568 7 in in IN cord-028721-x6f26ahr 2568 8 50 50 CD cord-028721-x6f26ahr 2568 9 % % NN cord-028721-x6f26ahr 2568 10 of of IN cord-028721-x6f26ahr 2568 11 patients patient NNS cord-028721-x6f26ahr 2568 12 . . . cord-028721-x6f26ahr 2569 1 • • NNP cord-028721-x6f26ahr 2570 1 Mental mental JJ cord-028721-x6f26ahr 2570 2 retardation retardation NN cord-028721-x6f26ahr 2570 3 . . . cord-028721-x6f26ahr 2571 1 Other other JJ cord-028721-x6f26ahr 2571 2 commonly commonly RB cord-028721-x6f26ahr 2571 3 associated associate VBN cord-028721-x6f26ahr 2571 4 conditions condition NNS cord-028721-x6f26ahr 2571 5 include include VBP cord-028721-x6f26ahr 2571 6 chronic chronic JJ cord-028721-x6f26ahr 2571 7 bronchitis bronchitis NN cord-028721-x6f26ahr 2571 8 ; ; : cord-028721-x6f26ahr 2571 9 varicose varicose JJ cord-028721-x6f26ahr 2571 10 veins vein NNS cord-028721-x6f26ahr 2571 11 ; ; , cord-028721-x6f26ahr 2571 12 cervical cervical JJ cord-028721-x6f26ahr 2571 13 rib rib NN cord-028721-x6f26ahr 2571 14 ; ; : cord-028721-x6f26ahr 2571 15 kyphosis kyphosis NN cord-028721-x6f26ahr 2571 16 ; ; , cord-028721-x6f26ahr 2571 17 scoliosis scoliosis NN cord-028721-x6f26ahr 2571 18 or or CC cord-028721-x6f26ahr 2571 19 pectus pectus NN cord-028721-x6f26ahr 2571 20 excavatum excavatum NN cord-028721-x6f26ahr 2571 21 ; ; : cord-028721-x6f26ahr 2571 22 and and CC cord-028721-x6f26ahr 2571 23 a a DT cord-028721-x6f26ahr 2571 24 high high JJ cord-028721-x6f26ahr 2571 25 incidence incidence NN cord-028721-x6f26ahr 2571 26 of of IN cord-028721-x6f26ahr 2571 27 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 2571 28 , , , cord-028721-x6f26ahr 2571 29 hypophyseal hypophyseal NN cord-028721-x6f26ahr 2571 30 , , , cord-028721-x6f26ahr 2571 31 thyroid thyroid NN cord-028721-x6f26ahr 2571 32 , , , cord-028721-x6f26ahr 2571 33 and and CC cord-028721-x6f26ahr 2571 34 pancreatic pancreatic JJ cord-028721-x6f26ahr 2571 35 dysfunction dysfunction NN cord-028721-x6f26ahr 2571 36 . . . cord-028721-x6f26ahr 2572 1 1084 1084 CD cord-028721-x6f26ahr 2573 1 The the DT cord-028721-x6f26ahr 2573 2 external external JJ cord-028721-x6f26ahr 2573 3 genitalia genitalia NNS cord-028721-x6f26ahr 2573 4 usually usually RB cord-028721-x6f26ahr 2573 5 are be VBP cord-028721-x6f26ahr 2573 6 normally normally RB cord-028721-x6f26ahr 2573 7 developed develop VBN cord-028721-x6f26ahr 2573 8 . . . cord-028721-x6f26ahr 2574 1 The the DT cord-028721-x6f26ahr 2574 2 testes testis NNS cord-028721-x6f26ahr 2574 3 are be VBP cord-028721-x6f26ahr 2574 4 usually usually RB cord-028721-x6f26ahr 2574 5 less less JJR cord-028721-x6f26ahr 2574 6 than than IN cord-028721-x6f26ahr 2574 7 2.5 2.5 CD cord-028721-x6f26ahr 2574 8 cm cm NNS cord-028721-x6f26ahr 2574 9 long long RB cord-028721-x6f26ahr 2574 10 , , , cord-028721-x6f26ahr 2574 11 although although IN cord-028721-x6f26ahr 2574 12 in in IN cord-028721-x6f26ahr 2574 13 some some DT cord-028721-x6f26ahr 2574 14 cases case NNS cord-028721-x6f26ahr 2574 15 of of IN cord-028721-x6f26ahr 2574 16 chromosomal chromosomal JJ cord-028721-x6f26ahr 2574 17 mosaicism mosaicism NN cord-028721-x6f26ahr 2574 18 they -PRON- PRP cord-028721-x6f26ahr 2574 19 are be VBP cord-028721-x6f26ahr 2574 20 of of IN cord-028721-x6f26ahr 2574 21 normal normal JJ cord-028721-x6f26ahr 2574 22 size size NN cord-028721-x6f26ahr 2574 23 . . . cord-028721-x6f26ahr 2575 1 1085 1085 CD cord-028721-x6f26ahr 2576 1 The the DT cord-028721-x6f26ahr 2576 2 incidence incidence NN cord-028721-x6f26ahr 2576 3 of of IN cord-028721-x6f26ahr 2576 4 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2576 5 is be VBZ cord-028721-x6f26ahr 2576 6 low low JJ cord-028721-x6f26ahr 2576 7 in in IN cord-028721-x6f26ahr 2576 8 47XXY 47xxy CD cord-028721-x6f26ahr 2576 9 patients patient NNS cord-028721-x6f26ahr 2576 10 but but CC cord-028721-x6f26ahr 2576 11 increased increase VBD cord-028721-x6f26ahr 2576 12 in in IN cord-028721-x6f26ahr 2576 13 mosaicism mosaicism NN cord-028721-x6f26ahr 2576 14 . . . cord-028721-x6f26ahr 2577 1 1086 1086 CD cord-028721-x6f26ahr 2577 2 Supernumerary Supernumerary NNP cord-028721-x6f26ahr 2577 3 X x NN cord-028721-x6f26ahr 2577 4 - - NN cord-028721-x6f26ahr 2577 5 chromosome chromosome NN cord-028721-x6f26ahr 2577 6 material material NN cord-028721-x6f26ahr 2577 7 is be VBZ cord-028721-x6f26ahr 2577 8 associated associate VBN cord-028721-x6f26ahr 2577 9 with with IN cord-028721-x6f26ahr 2577 10 a a DT cord-028721-x6f26ahr 2577 11 reduction reduction NN cord-028721-x6f26ahr 2577 12 of of IN cord-028721-x6f26ahr 2577 13 gray gray JJ cord-028721-x6f26ahr 2577 14 matter matter NN cord-028721-x6f26ahr 2577 15 in in IN cord-028721-x6f26ahr 2577 16 the the DT cord-028721-x6f26ahr 2577 17 left left JJ cord-028721-x6f26ahr 2577 18 temporal temporal JJ cord-028721-x6f26ahr 2577 19 lobule lobule NN cord-028721-x6f26ahr 2577 20 , , , cord-028721-x6f26ahr 2577 21 a a DT cord-028721-x6f26ahr 2577 22 fi fi NN cord-028721-x6f26ahr 2577 23 nding nding NN cord-028721-x6f26ahr 2577 24 correlated correlate VBN cord-028721-x6f26ahr 2577 25 with with IN cord-028721-x6f26ahr 2577 26 verbal verbal JJ cord-028721-x6f26ahr 2577 27 and and CC cord-028721-x6f26ahr 2577 28 language language NN cord-028721-x6f26ahr 2577 29 defi defi NNP cord-028721-x6f26ahr 2577 30 cits cits NNP cord-028721-x6f26ahr 2577 31 . . . cord-028721-x6f26ahr 2578 1 1087 1087 CD cord-028721-x6f26ahr 2578 2 Histologically Histologically NNP cord-028721-x6f26ahr 2578 3 , , , cord-028721-x6f26ahr 2578 4 the the DT cord-028721-x6f26ahr 2578 5 testes testis NNS cord-028721-x6f26ahr 2578 6 show show VBP cord-028721-x6f26ahr 2578 7 the the DT cord-028721-x6f26ahr 2578 8 classic classic JJ cord-028721-x6f26ahr 2578 9 picture picture NN cord-028721-x6f26ahr 2578 10 of of IN cord-028721-x6f26ahr 2578 11 tubular tubular JJ cord-028721-x6f26ahr 2578 12 dysgenesis dysgenesis FW cord-028721-x6f26ahr 2578 13 with with IN cord-028721-x6f26ahr 2578 14 small small JJ cord-028721-x6f26ahr 2578 15 hyalinized hyalinize VBN cord-028721-x6f26ahr 2578 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 2578 17 tubules tubule NNS cord-028721-x6f26ahr 2578 18 lacking lack VBG cord-028721-x6f26ahr 2578 19 elastic elastic JJ cord-028721-x6f26ahr 2578 20 fi fi NN cord-028721-x6f26ahr 2578 21 bers ber NNS cord-028721-x6f26ahr 2578 22 and and CC cord-028721-x6f26ahr 2578 23 pseudoadenomatous pseudoadenomatous JJ cord-028721-x6f26ahr 2578 24 clustering clustering NN cord-028721-x6f26ahr 2578 25 of of IN cord-028721-x6f26ahr 2578 26 Leydig Leydig NNP cord-028721-x6f26ahr 2578 27 cells cell NNS cord-028721-x6f26ahr 2578 28 ( ( -LRB- cord-028721-x6f26ahr 2578 29 Figs Figs NNP cord-028721-x6f26ahr 2578 30 12 12 CD cord-028721-x6f26ahr 2578 31 - - SYM cord-028721-x6f26ahr 2578 32 125 125 CD cord-028721-x6f26ahr 2578 33 , , , cord-028721-x6f26ahr 2578 34 12 12 CD cord-028721-x6f26ahr 2578 35 - - SYM cord-028721-x6f26ahr 2578 36 126 126 CD cord-028721-x6f26ahr 2578 37 ) ) -RRB- cord-028721-x6f26ahr 2578 38 . . . cord-028721-x6f26ahr 2579 1 1080 1080 CD cord-028721-x6f26ahr 2580 1 Most Most JJS cord-028721-x6f26ahr 2580 2 biopsies biopsy NNS cord-028721-x6f26ahr 2580 3 show show VBP cord-028721-x6f26ahr 2580 4 some some DT cord-028721-x6f26ahr 2580 5 tubules tubule NNS cord-028721-x6f26ahr 2580 6 with with IN cord-028721-x6f26ahr 2580 7 a a DT cord-028721-x6f26ahr 2580 8 few few JJ cord-028721-x6f26ahr 2580 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 2580 10 cells cell NNS cord-028721-x6f26ahr 2580 11 . . . cord-028721-x6f26ahr 2581 1 1088 1088 CD cord-028721-x6f26ahr 2582 1 These these DT cord-028721-x6f26ahr 2582 2 cells cell NNS cord-028721-x6f26ahr 2582 3 may may MD cord-028721-x6f26ahr 2582 4 be be VB cord-028721-x6f26ahr 2582 5 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2582 6 ( ( -LRB- cord-028721-x6f26ahr 2582 7 pseudostratifi pseudostratifi NNP cord-028721-x6f26ahr 2582 8 ed ed NN cord-028721-x6f26ahr 2582 9 distribution distribution NN cord-028721-x6f26ahr 2582 10 of of IN cord-028721-x6f26ahr 2582 11 nuclei nucleus NNS cord-028721-x6f26ahr 2582 12 that that WDT cord-028721-x6f26ahr 2582 13 are be VBP cord-028721-x6f26ahr 2582 14 dark dark JJ cord-028721-x6f26ahr 2582 15 and and CC cord-028721-x6f26ahr 2582 16 elongate elongate JJ cord-028721-x6f26ahr 2582 17 and and CC cord-028721-x6f26ahr 2582 18 contain contain VB cord-028721-x6f26ahr 2582 19 small small JJ cord-028721-x6f26ahr 2582 20 peripherally peripherally RB cord-028721-x6f26ahr 2582 21 placed place VBN cord-028721-x6f26ahr 2582 22 nucleoli nucleoli NNP cord-028721-x6f26ahr 2582 23 in in IN cord-028721-x6f26ahr 2582 24 tubules tubule NNS cord-028721-x6f26ahr 2582 25 without without IN cord-028721-x6f26ahr 2582 26 apparent apparent JJ cord-028721-x6f26ahr 2582 27 lumina lumina NNP cord-028721-x6f26ahr 2582 28 ) ) -RRB- cord-028721-x6f26ahr 2582 29 . . . cord-028721-x6f26ahr 2583 1 Sex sex NN cord-028721-x6f26ahr 2583 2 chromatin chromatin NN cord-028721-x6f26ahr 2583 3 may may MD cord-028721-x6f26ahr 2583 4 only only RB cord-028721-x6f26ahr 2583 5 be be VB cord-028721-x6f26ahr 2583 6 observed observe VBN cord-028721-x6f26ahr 2583 7 in in IN cord-028721-x6f26ahr 2583 8 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2583 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 2583 10 cells cell NNS cord-028721-x6f26ahr 2583 11 . . . cord-028721-x6f26ahr 2584 1 1089 1089 CD cord-028721-x6f26ahr 2585 1 This this DT cord-028721-x6f26ahr 2585 2 suggests suggest VBZ cord-028721-x6f26ahr 2585 3 that that IN cord-028721-x6f26ahr 2585 4 either either CC cord-028721-x6f26ahr 2585 5 there there EX cord-028721-x6f26ahr 2585 6 is be VBZ cord-028721-x6f26ahr 2585 7 testicular testicular JJ cord-028721-x6f26ahr 2585 8 mosaicism mosaicism NN cord-028721-x6f26ahr 2585 9 of of IN cord-028721-x6f26ahr 2585 10 the the DT cord-028721-x6f26ahr 2585 11 X x NN cord-028721-x6f26ahr 2585 12 chromosome chromosome NN cord-028721-x6f26ahr 2585 13 , , , cord-028721-x6f26ahr 2585 14 or or CC cord-028721-x6f26ahr 2585 15 that that IN cord-028721-x6f26ahr 2585 16 both both DT cord-028721-x6f26ahr 2585 17 X x NN cord-028721-x6f26ahr 2585 18 chromosomes chromosome NNS cord-028721-x6f26ahr 2585 19 are be VBP cord-028721-x6f26ahr 2585 20 heterochromatinized heterochromatinize VBN cord-028721-x6f26ahr 2585 21 . . . cord-028721-x6f26ahr 2586 1 In in IN cord-028721-x6f26ahr 2586 2 mosaicism mosaicism NN cord-028721-x6f26ahr 2586 3 , , , cord-028721-x6f26ahr 2586 4 Sertoli sertoli JJ cord-028721-x6f26ahr 2586 5 cell cell NN cord-028721-x6f26ahr 2586 6 - - HYPH cord-028721-x6f26ahr 2586 7 only only JJ cord-028721-x6f26ahr 2586 8 tubules tubule NNS cord-028721-x6f26ahr 2586 9 may may MD cord-028721-x6f26ahr 2586 10 be be VB cord-028721-x6f26ahr 2586 11 more more RBR cord-028721-x6f26ahr 2586 12 numerous numerous JJ cord-028721-x6f26ahr 2586 13 than than IN cord-028721-x6f26ahr 2586 14 hyalinized hyalinize VBN cord-028721-x6f26ahr 2586 15 ones one NNS cord-028721-x6f26ahr 2586 16 . . . cord-028721-x6f26ahr 2587 1 The the DT cord-028721-x6f26ahr 2587 2 reduced reduce VBN cord-028721-x6f26ahr 2587 3 testicular testicular NN cord-028721-x6f26ahr 2587 4 volume volume NN cord-028721-x6f26ahr 2587 5 gives give VBZ cord-028721-x6f26ahr 2587 6 an an DT cord-028721-x6f26ahr 2587 7 appearance appearance NN cord-028721-x6f26ahr 2587 8 of of IN cord-028721-x6f26ahr 2587 9 Leydig Leydig NNP cord-028721-x6f26ahr 2587 10 cell cell NN cord-028721-x6f26ahr 2587 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2587 12 , , , cord-028721-x6f26ahr 2587 13 1090 1090 CD cord-028721-x6f26ahr 2587 14 although although IN cord-028721-x6f26ahr 2587 15 quantitative quantitative JJ cord-028721-x6f26ahr 2587 16 studies study NNS cord-028721-x6f26ahr 2587 17 have have VBP cord-028721-x6f26ahr 2587 18 shown show VBN cord-028721-x6f26ahr 2587 19 that that IN cord-028721-x6f26ahr 2587 20 the the DT cord-028721-x6f26ahr 2587 21 total total JJ cord-028721-x6f26ahr 2587 22 number number NN cord-028721-x6f26ahr 2587 23 of of IN cord-028721-x6f26ahr 2587 24 Leydig Leydig NNP cord-028721-x6f26ahr 2587 25 cells cell NNS cord-028721-x6f26ahr 2587 26 is be VBZ cord-028721-x6f26ahr 2587 27 lower low JJR cord-028721-x6f26ahr 2587 28 than than IN cord-028721-x6f26ahr 2587 29 normal normal JJ cord-028721-x6f26ahr 2587 30 . . . cord-028721-x6f26ahr 2588 1 1091 1091 CD cord-028721-x6f26ahr 2589 1 Many many JJ cord-028721-x6f26ahr 2589 2 of of IN cord-028721-x6f26ahr 2589 3 the the DT cord-028721-x6f26ahr 2589 4 Leydig Leydig NNP cord-028721-x6f26ahr 2589 5 cells cell NNS cord-028721-x6f26ahr 2589 6 are be VBP cord-028721-x6f26ahr 2589 7 pleomorphic pleomorphic JJ cord-028721-x6f26ahr 2589 8 and and CC cord-028721-x6f26ahr 2589 9 some some DT cord-028721-x6f26ahr 2589 10 are be VBP cord-028721-x6f26ahr 2589 11 multivacuolated multivacuolated JJ cord-028721-x6f26ahr 2589 12 . . . cord-028721-x6f26ahr 2590 1 Immature immature JJ cord-028721-x6f26ahr 2590 2 fi fi NN cord-028721-x6f26ahr 2590 3 broblast broblast JJ cord-028721-x6f26ahr 2590 4 - - HYPH cord-028721-x6f26ahr 2590 5 like like JJ cord-028721-x6f26ahr 2590 6 Leydig Leydig NNP cord-028721-x6f26ahr 2590 7 cells cell NNS cord-028721-x6f26ahr 2590 8 may may MD cord-028721-x6f26ahr 2590 9 be be VB cord-028721-x6f26ahr 2590 10 present present JJ cord-028721-x6f26ahr 2590 11 . . . cord-028721-x6f26ahr 2591 1 The the DT cord-028721-x6f26ahr 2591 2 abnormally abnormally RB cord-028721-x6f26ahr 2591 3 differentiated differentiate VBN cord-028721-x6f26ahr 2591 4 Leydig Leydig NNP cord-028721-x6f26ahr 2591 5 cells cell NNS cord-028721-x6f26ahr 2591 6 have have VBP cord-028721-x6f26ahr 2591 7 nuclei nucleus NNS cord-028721-x6f26ahr 2591 8 with with IN cord-028721-x6f26ahr 2591 9 coarse coarse JJ cord-028721-x6f26ahr 2591 10 masses masse NNS cord-028721-x6f26ahr 2591 11 of of IN cord-028721-x6f26ahr 2591 12 dense dense JJ cord-028721-x6f26ahr 2591 13 chromatin chromatin NN cord-028721-x6f26ahr 2591 14 , , , cord-028721-x6f26ahr 2591 15 deep deep JJ cord-028721-x6f26ahr 2591 16 unfolding unfolding NN cord-028721-x6f26ahr 2591 17 of of IN cord-028721-x6f26ahr 2591 18 the the DT cord-028721-x6f26ahr 2591 19 nuclear nuclear JJ cord-028721-x6f26ahr 2591 20 envelope envelope NN cord-028721-x6f26ahr 2591 21 , , , cord-028721-x6f26ahr 2591 22 multiple multiple JJ cord-028721-x6f26ahr 2591 23 paracrystalline paracrystalline NN cord-028721-x6f26ahr 2591 24 inclusions inclusion NNS cord-028721-x6f26ahr 2591 25 instead instead RB cord-028721-x6f26ahr 2591 26 of of IN cord-028721-x6f26ahr 2591 27 Reinke Reinke NNP cord-028721-x6f26ahr 2591 28 's 's POS cord-028721-x6f26ahr 2591 29 crystalloids crystalloid NNS cord-028721-x6f26ahr 2591 30 , , , cord-028721-x6f26ahr 2591 31 multilayered multilayered JJ cord-028721-x6f26ahr 2591 32 concentric concentric JJ cord-028721-x6f26ahr 2591 33 cisternae cisternae NN cord-028721-x6f26ahr 2591 34 of of IN cord-028721-x6f26ahr 2591 35 smooth smooth JJ cord-028721-x6f26ahr 2591 36 endoplasmic endoplasmic NN cord-028721-x6f26ahr 2591 37 reticulum reticulum NN cord-028721-x6f26ahr 2591 38 , , , cord-028721-x6f26ahr 2591 39 large large JJ cord-028721-x6f26ahr 2591 40 masses masse NNS cord-028721-x6f26ahr 2591 41 of of IN cord-028721-x6f26ahr 2591 42 microfi microfi NNP cord-028721-x6f26ahr 2591 43 laments lament NNS cord-028721-x6f26ahr 2591 44 , , , cord-028721-x6f26ahr 2591 45 and and CC cord-028721-x6f26ahr 2591 46 scant scant JJ cord-028721-x6f26ahr 2591 47 lipid lipid NN cord-028721-x6f26ahr 2591 48 droplets droplet NNS cord-028721-x6f26ahr 2591 49 . . . cord-028721-x6f26ahr 2592 1 1092 1092 CD cord-028721-x6f26ahr 2593 1 Sex sex NN cord-028721-x6f26ahr 2593 2 chromatin chromatin NN cord-028721-x6f26ahr 2593 3 is be VBZ cord-028721-x6f26ahr 2593 4 apparent apparent JJ cord-028721-x6f26ahr 2593 5 in in IN cord-028721-x6f26ahr 2593 6 40 40 CD cord-028721-x6f26ahr 2593 7 - - SYM cord-028721-x6f26ahr 2593 8 70 70 CD cord-028721-x6f26ahr 2593 9 % % NN cord-028721-x6f26ahr 2593 10 of of IN cord-028721-x6f26ahr 2593 11 Leydig Leydig NNP cord-028721-x6f26ahr 2593 12 cells cell NNS cord-028721-x6f26ahr 2593 13 . . . cord-028721-x6f26ahr 2594 1 Leydig leydig NN cord-028721-x6f26ahr 2594 2 cell cell NN cord-028721-x6f26ahr 2594 3 function function NN cord-028721-x6f26ahr 2594 4 is be VBZ cord-028721-x6f26ahr 2594 5 insuffi insuffi NNP cord-028721-x6f26ahr 2594 6 cient cient NN cord-028721-x6f26ahr 2594 7 and and CC cord-028721-x6f26ahr 2594 8 androgen androgen NN cord-028721-x6f26ahr 2594 9 levels level NNS cord-028721-x6f26ahr 2594 10 are be VBP cord-028721-x6f26ahr 2594 11 less less JJR cord-028721-x6f26ahr 2594 12 than than IN cord-028721-x6f26ahr 2594 13 50 50 CD cord-028721-x6f26ahr 2594 14 % % NN cord-028721-x6f26ahr 2594 15 of of IN cord-028721-x6f26ahr 2594 16 normal normal JJ cord-028721-x6f26ahr 2594 17 . . . cord-028721-x6f26ahr 2595 1 Basal basal NN cord-028721-x6f26ahr 2595 2 FSH fsh NN cord-028721-x6f26ahr 2595 3 and and CC cord-028721-x6f26ahr 2595 4 LH LH NNP cord-028721-x6f26ahr 2595 5 are be VBP cord-028721-x6f26ahr 2595 6 markedly markedly RB cord-028721-x6f26ahr 2595 7 increased increase VBN cord-028721-x6f26ahr 2595 8 . . . cord-028721-x6f26ahr 2596 1 1084 1084 CD cord-028721-x6f26ahr 2596 2 , , , cord-028721-x6f26ahr 2596 3 1093 1093 CD cord-028721-x6f26ahr 2596 4 , , , cord-028721-x6f26ahr 2596 5 1094 1094 CD cord-028721-x6f26ahr 2597 1 In in IN cord-028721-x6f26ahr 2597 2 a a DT cord-028721-x6f26ahr 2597 3 few few JJ cord-028721-x6f26ahr 2597 4 patients patient NNS cord-028721-x6f26ahr 2597 5 the the DT cord-028721-x6f26ahr 2597 6 testicular testicular JJ cord-028721-x6f26ahr 2597 7 damage damage NN cord-028721-x6f26ahr 2597 8 is be VBZ cord-028721-x6f26ahr 2597 9 less less RBR cord-028721-x6f26ahr 2597 10 severe severe JJ cord-028721-x6f26ahr 2597 11 , , , cord-028721-x6f26ahr 2597 12 with with IN cord-028721-x6f26ahr 2597 13 some some DT cord-028721-x6f26ahr 2597 14 tubules tubule NNS cord-028721-x6f26ahr 2597 15 showing show VBG cord-028721-x6f26ahr 2597 16 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2597 17 and and CC cord-028721-x6f26ahr 2597 18 less less JJR cord-028721-x6f26ahr 2597 19 prominence prominence NN cord-028721-x6f26ahr 2597 20 of of IN cord-028721-x6f26ahr 2597 21 Leydig Leydig NNP cord-028721-x6f26ahr 2597 22 cells cell NNS cord-028721-x6f26ahr 2597 23 . . . cord-028721-x6f26ahr 2598 1 1095 1095 CD cord-028721-x6f26ahr 2599 1 Exceptionally exceptionally RB cord-028721-x6f26ahr 2599 2 , , , cord-028721-x6f26ahr 2599 3 complete complete JJ cord-028721-x6f26ahr 2599 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2599 5 and and CC cord-028721-x6f26ahr 2599 6 even even RB cord-028721-x6f26ahr 2599 7 paternity paternity NN cord-028721-x6f26ahr 2599 8 have have VBP cord-028721-x6f26ahr 2599 9 been be VBN cord-028721-x6f26ahr 2599 10 reported report VBN cord-028721-x6f26ahr 2599 11 . . . cord-028721-x6f26ahr 2600 1 1096 1096 CD cord-028721-x6f26ahr 2601 1 The the DT cord-028721-x6f26ahr 2601 2 XY XY NNP cord-028721-x6f26ahr 2601 3 / / SYM cord-028721-x6f26ahr 2601 4 XXY XXY NNP cord-028721-x6f26ahr 2601 5 karyotype karyotype NN cord-028721-x6f26ahr 2601 6 is be VBZ cord-028721-x6f26ahr 2601 7 the the DT cord-028721-x6f26ahr 2601 8 most most RBS cord-028721-x6f26ahr 2601 9 frequent frequent JJ cord-028721-x6f26ahr 2601 10 variant variant NN cord-028721-x6f26ahr 2601 11 of of IN cord-028721-x6f26ahr 2601 12 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2601 13 's 's POS cord-028721-x6f26ahr 2601 14 syndrome syndrome NN cord-028721-x6f26ahr 2601 15 with with IN cord-028721-x6f26ahr 2601 16 chromosomal chromosomal JJ cord-028721-x6f26ahr 2601 17 mosaicism mosaicism NN cord-028721-x6f26ahr 2601 18 . . . cord-028721-x6f26ahr 2602 1 In in IN cord-028721-x6f26ahr 2602 2 this this DT cord-028721-x6f26ahr 2602 3 condition condition NN cord-028721-x6f26ahr 2602 4 , , , cord-028721-x6f26ahr 2602 5 the the DT cord-028721-x6f26ahr 2602 6 clinical clinical JJ cord-028721-x6f26ahr 2602 7 abnormalities abnormality NNS cord-028721-x6f26ahr 2602 8 may may MD cord-028721-x6f26ahr 2602 9 be be VB cord-028721-x6f26ahr 2602 10 attenuated attenuate VBN cord-028721-x6f26ahr 2602 11 . . . cord-028721-x6f26ahr 2603 1 Gynecomastia gynecomastia NN cord-028721-x6f26ahr 2603 2 is be VBZ cord-028721-x6f26ahr 2603 3 present present JJ cord-028721-x6f26ahr 2603 4 in in IN cord-028721-x6f26ahr 2603 5 33 33 CD cord-028721-x6f26ahr 2603 6 % % NN cord-028721-x6f26ahr 2603 7 of of IN cord-028721-x6f26ahr 2603 8 cases case NNS cord-028721-x6f26ahr 2603 9 , , , cord-028721-x6f26ahr 2603 10 compared compare VBN cord-028721-x6f26ahr 2603 11 to to IN cord-028721-x6f26ahr 2603 12 a a DT cord-028721-x6f26ahr 2603 13 frequency frequency NN cord-028721-x6f26ahr 2603 14 of of IN cord-028721-x6f26ahr 2603 15 55 55 CD cord-028721-x6f26ahr 2603 16 % % NN cord-028721-x6f26ahr 2603 17 in in IN cord-028721-x6f26ahr 2603 18 men man NNS cord-028721-x6f26ahr 2603 19 with with IN cord-028721-x6f26ahr 2603 20 the the DT cord-028721-x6f26ahr 2603 21 47XXY 47xxy CD cord-028721-x6f26ahr 2603 22 karyotype karyotype NN cord-028721-x6f26ahr 2603 23 . . . cord-028721-x6f26ahr 2604 1 Azoospermia Azoospermia NNP cord-028721-x6f26ahr 2604 2 is be VBZ cord-028721-x6f26ahr 2604 3 found find VBN cord-028721-x6f26ahr 2604 4 in in IN cord-028721-x6f26ahr 2604 5 50 50 CD cord-028721-x6f26ahr 2604 6 % % NN cord-028721-x6f26ahr 2604 7 of of IN cord-028721-x6f26ahr 2604 8 cases case NNS cord-028721-x6f26ahr 2604 9 ( ( -LRB- cord-028721-x6f26ahr 2604 10 93 93 CD cord-028721-x6f26ahr 2604 11 % % NN cord-028721-x6f26ahr 2604 12 in in IN cord-028721-x6f26ahr 2604 13 XXY XXY NNP cord-028721-x6f26ahr 2604 14 men man NNS cord-028721-x6f26ahr 2604 15 ) ) -RRB- cord-028721-x6f26ahr 2604 16 . . . cord-028721-x6f26ahr 2605 1 The the DT cord-028721-x6f26ahr 2605 2 testes testis NNS cord-028721-x6f26ahr 2605 3 are be VBP cord-028721-x6f26ahr 2605 4 larger large JJR cord-028721-x6f26ahr 2605 5 and and CC cord-028721-x6f26ahr 2605 6 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2605 7 is be VBZ cord-028721-x6f26ahr 2605 8 more more RBR cord-028721-x6f26ahr 2605 9 developed develop VBN cord-028721-x6f26ahr 2605 10 in in IN cord-028721-x6f26ahr 2605 11 men man NNS cord-028721-x6f26ahr 2605 12 with with IN cord-028721-x6f26ahr 2605 13 XXY XXY NNP cord-028721-x6f26ahr 2605 14 ( ( -LRB- cord-028721-x6f26ahr 2605 15 Fig Fig NNP cord-028721-x6f26ahr 2605 16 . . . cord-028721-x6f26ahr 2605 17 12 12 CD cord-028721-x6f26ahr 2605 18 - - SYM cord-028721-x6f26ahr 2605 19 127 127 CD cord-028721-x6f26ahr 2605 20 ) ) -RRB- cord-028721-x6f26ahr 2605 21 . . . cord-028721-x6f26ahr 2606 1 Patients patient NNS cord-028721-x6f26ahr 2606 2 with with IN cord-028721-x6f26ahr 2606 3 the the DT cord-028721-x6f26ahr 2606 4 47XXY 47xxy CD cord-028721-x6f26ahr 2606 5 karyotype karyotype NN cord-028721-x6f26ahr 2606 6 who who WP cord-028721-x6f26ahr 2606 7 have have VBP cord-028721-x6f26ahr 2606 8 spermatozoa spermatozoa VBN cord-028721-x6f26ahr 2606 9 in in IN cord-028721-x6f26ahr 2606 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 2606 11 tubules tubule NNS cord-028721-x6f26ahr 2606 12 are be VBP cord-028721-x6f26ahr 2606 13 bearers bearer NNS cord-028721-x6f26ahr 2606 14 of of IN cord-028721-x6f26ahr 2606 15 46XY 46xy CD cord-028721-x6f26ahr 2606 16 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2606 17 and and CC cord-028721-x6f26ahr 2606 18 also also RB cord-028721-x6f26ahr 2606 19 of of IN cord-028721-x6f26ahr 2606 20 47XXY 47xxy CD cord-028721-x6f26ahr 2606 21 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2606 22 , , , cord-028721-x6f26ahr 2606 23 whereas whereas IN cord-028721-x6f26ahr 2606 24 those those DT cord-028721-x6f26ahr 2606 25 who who WP cord-028721-x6f26ahr 2606 26 have have VBP cord-028721-x6f26ahr 2606 27 no no DT cord-028721-x6f26ahr 2606 28 spermatozoa spermatozoa RB cord-028721-x6f26ahr 2606 29 have have VB cord-028721-x6f26ahr 2606 30 47XXY 47xxy CD cord-028721-x6f26ahr 2606 31 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2606 32 only only RB cord-028721-x6f26ahr 2606 33 ; ; : cord-028721-x6f26ahr 2606 34 these these DT cord-028721-x6f26ahr 2606 35 47XXY 47xxy JJ cord-028721-x6f26ahr 2606 36 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2606 37 may may MD cord-028721-x6f26ahr 2606 38 include include VB cord-028721-x6f26ahr 2606 39 some some DT cord-028721-x6f26ahr 2606 40 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2606 41 with with IN cord-028721-x6f26ahr 2606 42 23X 23x CD cord-028721-x6f26ahr 2606 43 or or CC cord-028721-x6f26ahr 2606 44 23Y 23y CD cord-028721-x6f26ahr 2606 45 chromosomal chromosomal JJ cord-028721-x6f26ahr 2606 46 complement complement NN cord-028721-x6f26ahr 2606 47 , , , cord-028721-x6f26ahr 2606 48 elevated elevated JJ cord-028721-x6f26ahr 2606 49 numbers number NNS cord-028721-x6f26ahr 2606 50 of of IN cord-028721-x6f26ahr 2606 51 both both DT cord-028721-x6f26ahr 2606 52 24XY 24xy CD cord-028721-x6f26ahr 2606 53 and and CC cord-028721-x6f26ahr 2606 54 24XX 24xx CD cord-028721-x6f26ahr 2606 55 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2606 56 , , , cord-028721-x6f26ahr 2606 57 and and CC cord-028721-x6f26ahr 2606 58 also also RB cord-028721-x6f26ahr 2606 59 a a DT cord-028721-x6f26ahr 2606 60 high high JJ cord-028721-x6f26ahr 2606 61 frequency frequency NN cord-028721-x6f26ahr 2606 62 of of IN cord-028721-x6f26ahr 2606 63 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2606 64 with with IN cord-028721-x6f26ahr 2606 65 21 21 CD cord-028721-x6f26ahr 2606 66 disomy disomy NN cord-028721-x6f26ahr 2606 67 ; ; : cord-028721-x6f26ahr 2606 68 this this DT cord-028721-x6f26ahr 2606 69 could could MD cord-028721-x6f26ahr 2606 70 be be VB cord-028721-x6f26ahr 2606 71 an an DT cord-028721-x6f26ahr 2606 72 important important JJ cord-028721-x6f26ahr 2606 73 risk risk NN cord-028721-x6f26ahr 2606 74 for for IN cord-028721-x6f26ahr 2606 75 gonosomy gonosomy NNP cord-028721-x6f26ahr 2606 76 1097 1097 CD cord-028721-x6f26ahr 2606 77 and and CC cord-028721-x6f26ahr 2606 78 also also RB cord-028721-x6f26ahr 2606 79 for for IN cord-028721-x6f26ahr 2606 80 trisomy trisomy NN cord-028721-x6f26ahr 2606 81 21 21 CD cord-028721-x6f26ahr 2606 82 . . . cord-028721-x6f26ahr 2607 1 1098 1098 CD cord-028721-x6f26ahr 2608 1 Genetic genetic JJ cord-028721-x6f26ahr 2608 2 counseling counseling NN cord-028721-x6f26ahr 2608 3 is be VBZ cord-028721-x6f26ahr 2608 4 advisable advisable JJ cord-028721-x6f26ahr 2608 5 in in IN cord-028721-x6f26ahr 2608 6 patients patient NNS cord-028721-x6f26ahr 2608 7 seeking seek VBG cord-028721-x6f26ahr 2608 8 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 2608 9 sperm sperm NN cord-028721-x6f26ahr 2608 10 injection injection NN cord-028721-x6f26ahr 2608 11 therapy therapy NN cord-028721-x6f26ahr 2608 12 . . . cord-028721-x6f26ahr 2609 1 Genetic genetic JJ cord-028721-x6f26ahr 2609 2 diagnosis diagnosis NN cord-028721-x6f26ahr 2609 3 before before IN cord-028721-x6f26ahr 2609 4 implantation implantation NN cord-028721-x6f26ahr 2609 5 of of IN cord-028721-x6f26ahr 2609 6 the the DT cord-028721-x6f26ahr 2609 7 zygote zygote NN cord-028721-x6f26ahr 2609 8 or or CC cord-028721-x6f26ahr 2609 9 prenatal prenatal JJ cord-028721-x6f26ahr 2609 10 diagnosis diagnosis NN cord-028721-x6f26ahr 2609 11 have have VBP cord-028721-x6f26ahr 2609 12 been be VBN cord-028721-x6f26ahr 2609 13 recommended recommend VBN cord-028721-x6f26ahr 2609 14 , , , cord-028721-x6f26ahr 2609 15 except except IN cord-028721-x6f26ahr 2609 16 for for IN cord-028721-x6f26ahr 2609 17 parents parent NNS cord-028721-x6f26ahr 2609 18 who who WP cord-028721-x6f26ahr 2609 19 assume assume VBP cord-028721-x6f26ahr 2609 20 the the DT cord-028721-x6f26ahr 2609 21 risk risk NN cord-028721-x6f26ahr 2609 22 of of IN cord-028721-x6f26ahr 2609 23 gonosomy gonosomy NN cord-028721-x6f26ahr 2609 24 . . . cord-028721-x6f26ahr 2609 25 _SP cord-028721-x6f26ahr 2610 1 The the DT cord-028721-x6f26ahr 2610 2 incidence incidence NN cord-028721-x6f26ahr 2610 3 of of IN cord-028721-x6f26ahr 2610 4 the the DT cord-028721-x6f26ahr 2610 5 48XXYY 48xxyy CD cord-028721-x6f26ahr 2610 6 karyotype karyotype NN cord-028721-x6f26ahr 2610 7 is be VBZ cord-028721-x6f26ahr 2610 8 estimated estimate VBN cord-028721-x6f26ahr 2610 9 to to TO cord-028721-x6f26ahr 2610 10 be be VB cord-028721-x6f26ahr 2610 11 0.04 0.04 CD cord-028721-x6f26ahr 2610 12 per per IN cord-028721-x6f26ahr 2610 13 1000 1000 CD cord-028721-x6f26ahr 2610 14 live live JJ cord-028721-x6f26ahr 2610 15 births birth NNS cord-028721-x6f26ahr 2610 16 . . . cord-028721-x6f26ahr 2611 1 [ [ -LRB- cord-028721-x6f26ahr 2611 2 1099 1099 CD cord-028721-x6f26ahr 2611 3 ] ] -RRB- cord-028721-x6f26ahr 2612 1 [ [ -LRB- cord-028721-x6f26ahr 2612 2 1100 1100 CD cord-028721-x6f26ahr 2612 3 ] ] -RRB- cord-028721-x6f26ahr 2613 1 [ [ -LRB- cord-028721-x6f26ahr 2613 2 1101 1101 CD cord-028721-x6f26ahr 2613 3 ] ] -RRB- cord-028721-x6f26ahr 2614 1 [ [ -LRB- cord-028721-x6f26ahr 2614 2 1102 1102 CD cord-028721-x6f26ahr 2614 3 ] ] -RRB- cord-028721-x6f26ahr 2615 1 This this DT cord-028721-x6f26ahr 2615 2 karyotype karyotype NN cord-028721-x6f26ahr 2615 3 may may MD cord-028721-x6f26ahr 2615 4 be be VB cord-028721-x6f26ahr 2615 5 associated associate VBN cord-028721-x6f26ahr 2615 6 with with IN cord-028721-x6f26ahr 2615 7 aggressive aggressive JJ cord-028721-x6f26ahr 2615 8 character character NN cord-028721-x6f26ahr 2615 9 , , , cord-028721-x6f26ahr 2615 10 antisocial antisocial JJ cord-028721-x6f26ahr 2615 11 behavior behavior NN cord-028721-x6f26ahr 2615 12 , , , cord-028721-x6f26ahr 2615 13 more more RBR cord-028721-x6f26ahr 2615 14 severe severe JJ cord-028721-x6f26ahr 2615 15 mental mental JJ cord-028721-x6f26ahr 2615 16 retardation retardation NN cord-028721-x6f26ahr 2615 17 , , , cord-028721-x6f26ahr 2615 18 and and CC cord-028721-x6f26ahr 2615 19 a a DT cord-028721-x6f26ahr 2615 20 higher high JJR cord-028721-x6f26ahr 2615 21 frequency frequency NN cord-028721-x6f26ahr 2615 22 of of IN cord-028721-x6f26ahr 2615 23 congenital congenital JJ cord-028721-x6f26ahr 2615 24 malformations malformation NNS cord-028721-x6f26ahr 2615 25 than than IN cord-028721-x6f26ahr 2615 26 the the DT cord-028721-x6f26ahr 2615 27 47XXY 47xxy JJ cord-028721-x6f26ahr 2615 28 karyotype karyotype NN cord-028721-x6f26ahr 2615 29 . . . cord-028721-x6f26ahr 2616 1 Men man NNS cord-028721-x6f26ahr 2616 2 with with IN cord-028721-x6f26ahr 2616 3 the the DT cord-028721-x6f26ahr 2616 4 48XXYY 48xxyy CD cord-028721-x6f26ahr 2616 5 karyotype karyotype NN cord-028721-x6f26ahr 2616 6 also also RB cord-028721-x6f26ahr 2616 7 have have VBP cord-028721-x6f26ahr 2616 8 characteristic characteristic JJ cord-028721-x6f26ahr 2616 9 dermatoglyphics dermatoglyphic NNS cord-028721-x6f26ahr 2616 10 with with IN cord-028721-x6f26ahr 2616 11 an an DT cord-028721-x6f26ahr 2616 12 increase increase NN cord-028721-x6f26ahr 2616 13 in in IN cord-028721-x6f26ahr 2616 14 arches arch NNS cord-028721-x6f26ahr 2616 15 , , , cord-028721-x6f26ahr 2616 16 a a DT cord-028721-x6f26ahr 2616 17 decrease decrease NN cord-028721-x6f26ahr 2616 18 in in IN cord-028721-x6f26ahr 2616 19 total total JJ cord-028721-x6f26ahr 2616 20 fi fi NNP cord-028721-x6f26ahr 2616 21 nger nger NNP cord-028721-x6f26ahr 2616 22 ridge ridge NNP cord-028721-x6f26ahr 2616 23 count count NNP cord-028721-x6f26ahr 2616 24 , , , cord-028721-x6f26ahr 2616 25 and and CC cord-028721-x6f26ahr 2616 26 ulnar ulnar JJ cord-028721-x6f26ahr 2616 27 triradiuses triradiuse NNS cord-028721-x6f26ahr 2616 28 associated associate VBN cord-028721-x6f26ahr 2616 29 with with IN cord-028721-x6f26ahr 2616 30 changes change NNS cord-028721-x6f26ahr 2616 31 in in IN cord-028721-x6f26ahr 2616 32 the the DT cord-028721-x6f26ahr 2616 33 hypothenar hypothenar NNP cord-028721-x6f26ahr 2616 34 region region NN cord-028721-x6f26ahr 2616 35 . . . cord-028721-x6f26ahr 2617 1 1103 1103 CD cord-028721-x6f26ahr 2617 2 Concentric concentric JJ cord-028721-x6f26ahr 2617 3 lamellae lamella NNS cord-028721-x6f26ahr 2617 4 of of IN cord-028721-x6f26ahr 2617 5 smooth smooth JJ cord-028721-x6f26ahr 2617 6 endoplasmic endoplasmic NN cord-028721-x6f26ahr 2617 7 reticulum reticulum NN cord-028721-x6f26ahr 2617 8 in in IN cord-028721-x6f26ahr 2617 9 Leydig Leydig NNP cord-028721-x6f26ahr 2617 10 cells cell NNS cord-028721-x6f26ahr 2617 11 are be VBP cord-028721-x6f26ahr 2617 12 a a DT cord-028721-x6f26ahr 2617 13 characteristic characteristic JJ cord-028721-x6f26ahr 2617 14 fi fi NN cord-028721-x6f26ahr 2617 15 nding nding NN cord-028721-x6f26ahr 2617 16 ( ( -LRB- cord-028721-x6f26ahr 2617 17 Fig Fig NNP cord-028721-x6f26ahr 2617 18 . . . cord-028721-x6f26ahr 2617 19 12 12 CD cord-028721-x6f26ahr 2617 20 - - SYM cord-028721-x6f26ahr 2617 21 128 128 CD cord-028721-x6f26ahr 2617 22 ) ) -RRB- cord-028721-x6f26ahr 2617 23 . . . cord-028721-x6f26ahr 2618 1 1104 1104 CD cord-028721-x6f26ahr 2618 2 Men man NNS cord-028721-x6f26ahr 2618 3 with with IN cord-028721-x6f26ahr 2618 4 the the DT cord-028721-x6f26ahr 2618 5 48XXXY 48xxxy CD cord-028721-x6f26ahr 2618 6 or or CC cord-028721-x6f26ahr 2618 7 49XXXYY 49xxxyy CD cord-028721-x6f26ahr 2618 8 karyotype karyotype NN cord-028721-x6f26ahr 2618 9 often often RB cord-028721-x6f26ahr 2618 10 have have VBP cord-028721-x6f26ahr 2618 11 skeletal skeletal JJ cord-028721-x6f26ahr 2618 12 malformations malformation NNS cord-028721-x6f26ahr 2618 13 , , , cord-028721-x6f26ahr 2618 14 principally principally RB cord-028721-x6f26ahr 2618 15 radioulnar radioulnar NNP cord-028721-x6f26ahr 2618 16 synostosis synostosis NNP cord-028721-x6f26ahr 2618 17 , , , cord-028721-x6f26ahr 2618 18 and and CC cord-028721-x6f26ahr 2618 19 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2618 20 . . . cord-028721-x6f26ahr 2619 1 1105 1105 CD cord-028721-x6f26ahr 2620 1 In in IN cord-028721-x6f26ahr 2620 2 addition addition NN cord-028721-x6f26ahr 2620 3 to to IN cord-028721-x6f26ahr 2620 4 the the DT cord-028721-x6f26ahr 2620 5 characteristic characteristic JJ cord-028721-x6f26ahr 2620 6 symptoms symptom NNS cord-028721-x6f26ahr 2620 7 of of IN cord-028721-x6f26ahr 2620 8 47XXY 47xxy CD cord-028721-x6f26ahr 2620 9 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2620 10 's 's POS cord-028721-x6f26ahr 2620 11 syndrome syndrome NN cord-028721-x6f26ahr 2620 12 , , , cord-028721-x6f26ahr 2620 13 1106 1106 CD cord-028721-x6f26ahr 2620 14 men man NNS cord-028721-x6f26ahr 2620 15 with with IN cord-028721-x6f26ahr 2620 16 the the DT cord-028721-x6f26ahr 2620 17 49XXXXY 49xxxxy CD cord-028721-x6f26ahr 2620 18 karyotype karyotype NN cord-028721-x6f26ahr 2620 19 have have VBP cord-028721-x6f26ahr 2620 20 other other JJ cord-028721-x6f26ahr 2620 21 abnormalities abnormality NNS cord-028721-x6f26ahr 2620 22 , , , cord-028721-x6f26ahr 2620 23 including include VBG cord-028721-x6f26ahr 2620 24 severe severe JJ cord-028721-x6f26ahr 2620 25 mental mental JJ cord-028721-x6f26ahr 2620 26 retardation retardation NN cord-028721-x6f26ahr 2620 27 , , , cord-028721-x6f26ahr 2620 28 hypoplasia hypoplasia NN cord-028721-x6f26ahr 2620 29 of of IN cord-028721-x6f26ahr 2620 30 external external JJ cord-028721-x6f26ahr 2620 31 genitalia genitalia NNS cord-028721-x6f26ahr 2620 32 , , , cord-028721-x6f26ahr 2620 33 cardiac cardiac JJ cord-028721-x6f26ahr 2620 34 malformations malformation NNS cord-028721-x6f26ahr 2620 35 , , , cord-028721-x6f26ahr 2620 36 radioulnar radioulnar NNP cord-028721-x6f26ahr 2620 37 synostosis synostosis NNP cord-028721-x6f26ahr 2620 38 , , , cord-028721-x6f26ahr 2620 39 microcephaly microcephaly NNS cord-028721-x6f26ahr 2620 40 , , , cord-028721-x6f26ahr 2620 41 and and CC cord-028721-x6f26ahr 2620 42 a a DT cord-028721-x6f26ahr 2620 43 high high JJ cord-028721-x6f26ahr 2620 44 arched arched JJ cord-028721-x6f26ahr 2620 45 palate palate NN cord-028721-x6f26ahr 2620 46 . . . cord-028721-x6f26ahr 2621 1 1107 1107 CD cord-028721-x6f26ahr 2621 2 Association Association NNP cord-028721-x6f26ahr 2621 3 of of IN cord-028721-x6f26ahr 2621 4 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2621 5 's 's POS cord-028721-x6f26ahr 2621 6 syndrome syndrome NN cord-028721-x6f26ahr 2621 7 with with IN cord-028721-x6f26ahr 2621 8 malignancy malignancy NN cord-028721-x6f26ahr 2621 9 Patients patient NNS cord-028721-x6f26ahr 2621 10 with with IN cord-028721-x6f26ahr 2621 11 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2621 12 's 's POS cord-028721-x6f26ahr 2621 13 syndrome syndrome NN cord-028721-x6f26ahr 2621 14 have have VBP cord-028721-x6f26ahr 2621 15 a a DT cord-028721-x6f26ahr 2621 16 higher high JJR cord-028721-x6f26ahr 2621 17 incidence incidence NN cord-028721-x6f26ahr 2621 18 of of IN cord-028721-x6f26ahr 2621 19 malignancy malignancy NN cord-028721-x6f26ahr 2621 20 than than IN cord-028721-x6f26ahr 2621 21 the the DT cord-028721-x6f26ahr 2621 22 general general JJ cord-028721-x6f26ahr 2621 23 population population NN cord-028721-x6f26ahr 2621 24 . . . cord-028721-x6f26ahr 2622 1 The the DT cord-028721-x6f26ahr 2622 2 association association NN cord-028721-x6f26ahr 2622 3 was be VBD cord-028721-x6f26ahr 2622 4 fi fi NNP cord-028721-x6f26ahr 2622 5 rst rst NNP cord-028721-x6f26ahr 2622 6 discovered discover VBN cord-028721-x6f26ahr 2622 7 with with IN cord-028721-x6f26ahr 2622 8 breast breast NN cord-028721-x6f26ahr 2622 9 carcinoma carcinoma NN cord-028721-x6f26ahr 2622 10 , , , cord-028721-x6f26ahr 2622 11 1108 1108 CD cord-028721-x6f26ahr 2622 12 which which WDT cord-028721-x6f26ahr 2622 13 had have VBD cord-028721-x6f26ahr 2622 14 an an DT cord-028721-x6f26ahr 2622 15 incidence incidence NN cord-028721-x6f26ahr 2622 16 20 20 CD cord-028721-x6f26ahr 2622 17 times time NNS cord-028721-x6f26ahr 2622 18 greater great JJR cord-028721-x6f26ahr 2622 19 than than IN cord-028721-x6f26ahr 2622 20 in in IN cord-028721-x6f26ahr 2622 21 the the DT cord-028721-x6f26ahr 2622 22 general general JJ cord-028721-x6f26ahr 2622 23 male male JJ cord-028721-x6f26ahr 2622 24 population population NN cord-028721-x6f26ahr 2622 25 , , , cord-028721-x6f26ahr 2622 26 1109 1109 CD cord-028721-x6f26ahr 2622 27 and and CC cord-028721-x6f26ahr 2622 28 is be VBZ cord-028721-x6f26ahr 2622 29 related relate VBN cord-028721-x6f26ahr 2622 30 to to IN cord-028721-x6f26ahr 2622 31 hormonal hormonal JJ cord-028721-x6f26ahr 2622 32 stimulation stimulation NN cord-028721-x6f26ahr 2622 33 . . . cord-028721-x6f26ahr 2623 1 1110 1110 CD cord-028721-x6f26ahr 2624 1 Although although IN cord-028721-x6f26ahr 2624 2 testicular testicular JJ cord-028721-x6f26ahr 2624 3 germ germ NN cord-028721-x6f26ahr 2624 4 cell cell NN cord-028721-x6f26ahr 2624 5 tumor tumor NN cord-028721-x6f26ahr 2624 6 is be VBZ cord-028721-x6f26ahr 2624 7 rare rare JJ cord-028721-x6f26ahr 2624 8 in in IN cord-028721-x6f26ahr 2624 9 these these DT cord-028721-x6f26ahr 2624 10 patients patient NNS cord-028721-x6f26ahr 2624 11 , , , cord-028721-x6f26ahr 2624 12 1111 1111 CD cord-028721-x6f26ahr 2624 13 extragonadal extragonadal JJ cord-028721-x6f26ahr 2624 14 germ germ NN cord-028721-x6f26ahr 2624 15 cell cell NN cord-028721-x6f26ahr 2624 16 tumor tumor NN cord-028721-x6f26ahr 2624 17 is be VBZ cord-028721-x6f26ahr 2624 18 30 30 CD cord-028721-x6f26ahr 2624 19 - - SYM cord-028721-x6f26ahr 2624 20 40 40 CD cord-028721-x6f26ahr 2624 21 times time NNS cord-028721-x6f26ahr 2624 22 more more RBR cord-028721-x6f26ahr 2624 23 frequent frequent JJ cord-028721-x6f26ahr 2624 24 than than IN cord-028721-x6f26ahr 2624 25 in in IN cord-028721-x6f26ahr 2624 26 the the DT cord-028721-x6f26ahr 2624 27 general general JJ cord-028721-x6f26ahr 2624 28 population population NN cord-028721-x6f26ahr 2624 29 . . . cord-028721-x6f26ahr 2625 1 Most Most JJS cord-028721-x6f26ahr 2625 2 occur occur VBP cord-028721-x6f26ahr 2625 3 in in IN cord-028721-x6f26ahr 2625 4 the the DT cord-028721-x6f26ahr 2625 5 mediastinum mediastinum NN cord-028721-x6f26ahr 2625 6 ( ( -LRB- cord-028721-x6f26ahr 2625 7 about about RB cord-028721-x6f26ahr 2625 8 71 71 CD cord-028721-x6f26ahr 2625 9 % % NN cord-028721-x6f26ahr 2625 10 ) ) -RRB- cord-028721-x6f26ahr 2625 11 and and CC cord-028721-x6f26ahr 2625 12 are be VBP cord-028721-x6f26ahr 2625 13 less less RBR cord-028721-x6f26ahr 2625 14 frequent frequent JJ cord-028721-x6f26ahr 2625 15 in in IN cord-028721-x6f26ahr 2625 16 the the DT cord-028721-x6f26ahr 2625 17 pineal pineal NN cord-028721-x6f26ahr 2625 18 gland gland NN cord-028721-x6f26ahr 2625 19 , , , cord-028721-x6f26ahr 2625 20 central central JJ cord-028721-x6f26ahr 2625 21 nervous nervous JJ cord-028721-x6f26ahr 2625 22 system system NN cord-028721-x6f26ahr 2625 23 , , , cord-028721-x6f26ahr 2625 24 and and CC cord-028721-x6f26ahr 2625 25 retroperitoneum retroperitoneum NN cord-028721-x6f26ahr 2625 26 . . . cord-028721-x6f26ahr 2626 1 The the DT cord-028721-x6f26ahr 2626 2 most most RBS cord-028721-x6f26ahr 2626 3 frequent frequent JJ cord-028721-x6f26ahr 2626 4 types type NNS cord-028721-x6f26ahr 2626 5 are be VBP cord-028721-x6f26ahr 2626 6 teratoma teratoma NN cord-028721-x6f26ahr 2626 7 and and CC cord-028721-x6f26ahr 2626 8 choriocarcinoma choriocarcinoma NN cord-028721-x6f26ahr 2626 9 ; ; : cord-028721-x6f26ahr 2626 10 embryonal embryonal JJ cord-028721-x6f26ahr 2626 11 carcinoma carcinoma NN cord-028721-x6f26ahr 2626 12 and and CC cord-028721-x6f26ahr 2626 13 seminoma seminoma NN cord-028721-x6f26ahr 2626 14 are be VBP cord-028721-x6f26ahr 2626 15 rare rare JJ cord-028721-x6f26ahr 2626 16 . . . cord-028721-x6f26ahr 2627 1 [ [ -LRB- cord-028721-x6f26ahr 2627 2 1112 1112 CD cord-028721-x6f26ahr 2627 3 ] ] -RRB- cord-028721-x6f26ahr 2628 1 [ [ -LRB- cord-028721-x6f26ahr 2628 2 1113 1113 CD cord-028721-x6f26ahr 2628 3 ] ] -RRB- cord-028721-x6f26ahr 2629 1 [ [ -LRB- cord-028721-x6f26ahr 2629 2 1114 1114 CD cord-028721-x6f26ahr 2629 3 ] ] -RRB- cord-028721-x6f26ahr 2630 1 The the DT cord-028721-x6f26ahr 2630 2 extragonadal extragonadal JJ cord-028721-x6f26ahr 2630 3 origin origin NN cord-028721-x6f26ahr 2630 4 of of IN cord-028721-x6f26ahr 2630 5 germ germ NN cord-028721-x6f26ahr 2630 6 cell cell NN cord-028721-x6f26ahr 2630 7 tumors tumor NNS cord-028721-x6f26ahr 2630 8 has have VBZ cord-028721-x6f26ahr 2630 9 been be VBN cord-028721-x6f26ahr 2630 10 attributed attribute VBN cord-028721-x6f26ahr 2630 11 to to IN cord-028721-x6f26ahr 2630 12 abnormal abnormal JJ cord-028721-x6f26ahr 2630 13 germ germ NN cord-028721-x6f26ahr 2630 14 cell cell NN cord-028721-x6f26ahr 2630 15 migration migration NN cord-028721-x6f26ahr 2630 16 from from IN cord-028721-x6f26ahr 2630 17 the the DT cord-028721-x6f26ahr 2630 18 yolk yolk NN cord-028721-x6f26ahr 2630 19 sac sac NN cord-028721-x6f26ahr 2630 20 . . . cord-028721-x6f26ahr 2631 1 The the DT cord-028721-x6f26ahr 2631 2 high high JJ cord-028721-x6f26ahr 2631 3 incidence incidence NN cord-028721-x6f26ahr 2631 4 has have VBZ cord-028721-x6f26ahr 2631 5 been be VBN cord-028721-x6f26ahr 2631 6 attributed attribute VBN cord-028721-x6f26ahr 2631 7 to to IN cord-028721-x6f26ahr 2631 8 elevated elevate VBN cord-028721-x6f26ahr 2631 9 hormone hormone NN cord-028721-x6f26ahr 2631 10 levels level NNS cord-028721-x6f26ahr 2631 11 and and CC cord-028721-x6f26ahr 2631 12 chromosomal chromosomal JJ cord-028721-x6f26ahr 2631 13 anomaly anomaly NN cord-028721-x6f26ahr 2631 14 . . . cord-028721-x6f26ahr 2632 1 1115 1115 CD cord-028721-x6f26ahr 2633 1 In in IN cord-028721-x6f26ahr 2633 2 a a DT cord-028721-x6f26ahr 2633 3 patient patient NN cord-028721-x6f26ahr 2633 4 with with IN cord-028721-x6f26ahr 2633 5 the the DT cord-028721-x6f26ahr 2633 6 XY XY NNP cord-028721-x6f26ahr 2633 7 / / SYM cord-028721-x6f26ahr 2633 8 XXY XXY NNP cord-028721-x6f26ahr 2633 9 chromosomal chromosomal JJ cord-028721-x6f26ahr 2633 10 mosaic mosaic NN cord-028721-x6f26ahr 2633 11 and and CC cord-028721-x6f26ahr 2633 12 bronchogenic bronchogenic JJ cord-028721-x6f26ahr 2633 13 carcinoma carcinoma NN cord-028721-x6f26ahr 2633 14 , , , cord-028721-x6f26ahr 2633 15 cultured cultured JJ cord-028721-x6f26ahr 2633 16 XXY XXY NNP cord-028721-x6f26ahr 2633 17 fi fi NN cord-028721-x6f26ahr 2633 18 broblasts broblasts NNP cord-028721-x6f26ahr 2633 19 transformed transform VBD cord-028721-x6f26ahr 2633 20 three three CD cord-028721-x6f26ahr 2633 21 times time NNS cord-028721-x6f26ahr 2633 22 more more RBR cord-028721-x6f26ahr 2633 23 frequently frequently RB cord-028721-x6f26ahr 2633 24 when when WRB cord-028721-x6f26ahr 2633 25 exposed expose VBN cord-028721-x6f26ahr 2633 26 to to IN cord-028721-x6f26ahr 2633 27 SV40 SV40 NNP cord-028721-x6f26ahr 2633 28 virus virus NN cord-028721-x6f26ahr 2633 29 than than IN cord-028721-x6f26ahr 2633 30 did do VBD cord-028721-x6f26ahr 2633 31 fi fi VB cord-028721-x6f26ahr 2633 32 broblasts broblast NNS cord-028721-x6f26ahr 2633 33 from from IN cord-028721-x6f26ahr 2633 34 normal normal JJ cord-028721-x6f26ahr 2633 35 men man NNS cord-028721-x6f26ahr 2633 36 . . . cord-028721-x6f26ahr 2634 1 1116 1116 CD cord-028721-x6f26ahr 2635 1 Other other JJ cord-028721-x6f26ahr 2635 2 tumors tumor NNS cord-028721-x6f26ahr 2635 3 reported report VBN cord-028721-x6f26ahr 2635 4 in in IN cord-028721-x6f26ahr 2635 5 patients patient NNS cord-028721-x6f26ahr 2635 6 with with IN cord-028721-x6f26ahr 2635 7 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2635 8 's 's POS cord-028721-x6f26ahr 2635 9 syndrome syndrome NN cord-028721-x6f26ahr 2635 10 ( ( -LRB- cord-028721-x6f26ahr 2635 11 lymphoma lymphoma NN cord-028721-x6f26ahr 2635 12 , , , cord-028721-x6f26ahr 2635 13 leukemia leukemia NN cord-028721-x6f26ahr 2635 14 , , , cord-028721-x6f26ahr 2635 15 bronchogenic bronchogenic NNP cord-028721-x6f26ahr 2635 16 carcinoma carcinoma NN cord-028721-x6f26ahr 2635 17 , , , cord-028721-x6f26ahr 2635 18 urothelial urothelial JJ cord-028721-x6f26ahr 2635 19 carcinoma carcinoma NN cord-028721-x6f26ahr 2635 20 of of IN cord-028721-x6f26ahr 2635 21 the the DT cord-028721-x6f26ahr 2635 22 bladder bladder NN cord-028721-x6f26ahr 2635 23 , , , cord-028721-x6f26ahr 2635 24 adrenal adrenal JJ cord-028721-x6f26ahr 2635 25 carcinoma carcinoma NN cord-028721-x6f26ahr 2635 26 , , , cord-028721-x6f26ahr 2635 27 prostatic prostatic JJ cord-028721-x6f26ahr 2635 28 adenocarcinoma adenocarcinoma NN cord-028721-x6f26ahr 2635 29 , , , cord-028721-x6f26ahr 2635 30 testicular testicular JJ cord-028721-x6f26ahr 2635 31 Leydig Leydig NNP cord-028721-x6f26ahr 2635 32 cell cell NN cord-028721-x6f26ahr 2635 33 tumor tumor NN cord-028721-x6f26ahr 2635 34 , , , cord-028721-x6f26ahr 2635 35 and and CC cord-028721-x6f26ahr 2635 36 epidermoid epidermoid JJ cord-028721-x6f26ahr 2635 37 cyst cyst NNP cord-028721-x6f26ahr 2635 38 ) ) -RRB- cord-028721-x6f26ahr 2635 39 do do VBP cord-028721-x6f26ahr 2635 40 not not RB cord-028721-x6f26ahr 2635 41 appear appear VB cord-028721-x6f26ahr 2635 42 to to TO cord-028721-x6f26ahr 2635 43 have have VB cord-028721-x6f26ahr 2635 44 a a DT cord-028721-x6f26ahr 2635 45 higher high JJR cord-028721-x6f26ahr 2635 46 incidence incidence NN cord-028721-x6f26ahr 2635 47 than than IN cord-028721-x6f26ahr 2635 48 in in IN cord-028721-x6f26ahr 2635 49 the the DT cord-028721-x6f26ahr 2635 50 general general JJ cord-028721-x6f26ahr 2635 51 population population NN cord-028721-x6f26ahr 2635 52 . . . cord-028721-x6f26ahr 2636 1 [ [ -LRB- cord-028721-x6f26ahr 2636 2 1117 1117 CD cord-028721-x6f26ahr 2636 3 ] ] -RRB- cord-028721-x6f26ahr 2636 4 [ [ -LRB- cord-028721-x6f26ahr 2636 5 1118 1118 CD cord-028721-x6f26ahr 2636 6 ] ] -RRB- cord-028721-x6f26ahr 2637 1 [ [ -LRB- cord-028721-x6f26ahr 2637 2 1119 1119 CD cord-028721-x6f26ahr 2637 3 ] ] -RRB- cord-028721-x6f26ahr 2638 1 [ [ -LRB- cord-028721-x6f26ahr 2638 2 1120 1120 CD cord-028721-x6f26ahr 2638 3 ] ] -RRB- cord-028721-x6f26ahr 2639 1 Occurrence occurrence NN cord-028721-x6f26ahr 2639 2 of of IN cord-028721-x6f26ahr 2639 3 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2639 4 's 's POS cord-028721-x6f26ahr 2639 5 syndrome syndrome NN cord-028721-x6f26ahr 2639 6 in in IN cord-028721-x6f26ahr 2639 7 childhood childhood NN cord-028721-x6f26ahr 2640 1 Early early JJ cord-028721-x6f26ahr 2640 2 identifi identifi NNP cord-028721-x6f26ahr 2640 3 cation cation NN cord-028721-x6f26ahr 2640 4 of of IN cord-028721-x6f26ahr 2640 5 this this DT cord-028721-x6f26ahr 2640 6 syndrome syndrome NN cord-028721-x6f26ahr 2640 7 is be VBZ cord-028721-x6f26ahr 2640 8 possible possible JJ cord-028721-x6f26ahr 2640 9 with with IN cord-028721-x6f26ahr 2640 10 systematic systematic JJ cord-028721-x6f26ahr 2640 11 cytogenetic cytogenetic JJ cord-028721-x6f26ahr 2640 12 study study NN cord-028721-x6f26ahr 2640 13 of of IN cord-028721-x6f26ahr 2640 14 newborns newborn NNS cord-028721-x6f26ahr 2640 15 with with IN cord-028721-x6f26ahr 2640 16 positive positive JJ cord-028721-x6f26ahr 2640 17 sex sex NN cord-028721-x6f26ahr 2640 18 chromatin chromatin NN cord-028721-x6f26ahr 2640 19 or or CC cord-028721-x6f26ahr 2640 20 mental mental JJ cord-028721-x6f26ahr 2640 21 retardation retardation NN cord-028721-x6f26ahr 2640 22 . . . cord-028721-x6f26ahr 2641 1 1121 1121 CD cord-028721-x6f26ahr 2642 1 Several several JJ cord-028721-x6f26ahr 2642 2 clinical clinical JJ cord-028721-x6f26ahr 2642 3 symptoms symptom NNS cord-028721-x6f26ahr 2642 4 suggest suggest VBP cord-028721-x6f26ahr 2642 5 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2642 6 's 's POS cord-028721-x6f26ahr 2642 7 syndrome syndrome NN cord-028721-x6f26ahr 2642 8 . . . cord-028721-x6f26ahr 2643 1 Initial initial JJ cord-028721-x6f26ahr 2643 2 symptoms symptom NNS cord-028721-x6f26ahr 2643 3 include include VBP cord-028721-x6f26ahr 2643 4 decreased decrease VBN cord-028721-x6f26ahr 2643 5 muscle muscle NN cord-028721-x6f26ahr 2643 6 tone tone NN cord-028721-x6f26ahr 2643 7 , , , cord-028721-x6f26ahr 2643 8 delayed delay VBN cord-028721-x6f26ahr 2643 9 speech speech NN cord-028721-x6f26ahr 2643 10 , , , cord-028721-x6f26ahr 2643 11 and and CC cord-028721-x6f26ahr 2643 12 poor poor JJ cord-028721-x6f26ahr 2643 13 language language NN cord-028721-x6f26ahr 2643 14 skills skill NNS cord-028721-x6f26ahr 2643 15 with with IN cord-028721-x6f26ahr 2643 16 an an DT cord-028721-x6f26ahr 2643 17 increased increase VBN cord-028721-x6f26ahr 2643 18 incidence incidence NN cord-028721-x6f26ahr 2643 19 of of IN cord-028721-x6f26ahr 2643 20 reading read VBG cord-028721-x6f26ahr 2643 21 diffi diffi NNP cord-028721-x6f26ahr 2643 22 culties cultie NNS cord-028721-x6f26ahr 2643 23 and and CC cord-028721-x6f26ahr 2643 24 dyslexia dyslexia NN cord-028721-x6f26ahr 2643 25 . . . cord-028721-x6f26ahr 2644 1 1122 1122 CD cord-028721-x6f26ahr 2645 1 Later later RB cord-028721-x6f26ahr 2645 2 , , , cord-028721-x6f26ahr 2645 3 there there EX cord-028721-x6f26ahr 2645 4 may may MD cord-028721-x6f26ahr 2645 5 be be VB cord-028721-x6f26ahr 2645 6 recognition recognition NN cord-028721-x6f26ahr 2645 7 of of IN cord-028721-x6f26ahr 2645 8 mental mental JJ cord-028721-x6f26ahr 2645 9 retardation retardation NN cord-028721-x6f26ahr 2645 10 , , , cord-028721-x6f26ahr 2645 11 1123 1123 CD cord-028721-x6f26ahr 2645 12 psychiatric psychiatric JJ cord-028721-x6f26ahr 2645 13 problems problem NNS cord-028721-x6f26ahr 2645 14 , , , cord-028721-x6f26ahr 2645 15 excessive excessive JJ cord-028721-x6f26ahr 2645 16 stature stature NN cord-028721-x6f26ahr 2645 17 for for IN cord-028721-x6f26ahr 2645 18 age age NN cord-028721-x6f26ahr 2645 19 , , , cord-028721-x6f26ahr 2645 20 disproportionately disproportionately RB cord-028721-x6f26ahr 2645 21 long long JJ cord-028721-x6f26ahr 2645 22 legs leg NNS cord-028721-x6f26ahr 2645 23 , , , cord-028721-x6f26ahr 2645 24 micropenis micropenis NN cord-028721-x6f26ahr 2645 25 , , , cord-028721-x6f26ahr 2645 26 and and CC cord-028721-x6f26ahr 2645 27 small small JJ cord-028721-x6f26ahr 2645 28 testes testis NNS cord-028721-x6f26ahr 2645 29 . . . cord-028721-x6f26ahr 2646 1 [ [ -LRB- cord-028721-x6f26ahr 2646 2 1124 1124 CD cord-028721-x6f26ahr 2646 3 ] ] -RRB- cord-028721-x6f26ahr 2646 4 [ [ -LRB- cord-028721-x6f26ahr 2646 5 1125 1125 CD cord-028721-x6f26ahr 2646 6 ] ] -RRB- cord-028721-x6f26ahr 2646 7 [ [ -LRB- cord-028721-x6f26ahr 2646 8 1126 1126 CD cord-028721-x6f26ahr 2646 9 ] ] -RRB- cord-028721-x6f26ahr 2646 10 [ [ -LRB- cord-028721-x6f26ahr 2646 11 1127 1127 CD cord-028721-x6f26ahr 2646 12 ] ] -RRB- cord-028721-x6f26ahr 2647 1 Androgen androgen NN cord-028721-x6f26ahr 2647 2 defi defi NNP cord-028721-x6f26ahr 2647 3 ciency ciency NN cord-028721-x6f26ahr 2647 4 is be VBZ cord-028721-x6f26ahr 2647 5 an an DT cord-028721-x6f26ahr 2647 6 early early JJ cord-028721-x6f26ahr 2647 7 fi fi NN cord-028721-x6f26ahr 2647 8 nding nding NN cord-028721-x6f26ahr 2647 9 . . . cord-028721-x6f26ahr 2648 1 1128 1128 CD cord-028721-x6f26ahr 2649 1 Testicular testicular JJ cord-028721-x6f26ahr 2649 2 biopsy biopsy NN cord-028721-x6f26ahr 2649 3 reveals reveal VBZ cord-028721-x6f26ahr 2649 4 scant scant JJ cord-028721-x6f26ahr 2649 5 or or CC cord-028721-x6f26ahr 2649 6 absent absent JJ cord-028721-x6f26ahr 2649 7 germ germ NN cord-028721-x6f26ahr 2649 8 cells cell NNS cord-028721-x6f26ahr 2649 9 . . . cord-028721-x6f26ahr 2650 1 Quantitative quantitative JJ cord-028721-x6f26ahr 2650 2 studies study NNS cord-028721-x6f26ahr 2650 3 indicate indicate VBP cord-028721-x6f26ahr 2650 4 that that IN cord-028721-x6f26ahr 2650 5 the the DT cord-028721-x6f26ahr 2650 6 number number NN cord-028721-x6f26ahr 2650 7 of of IN cord-028721-x6f26ahr 2650 8 germ germ NN cord-028721-x6f26ahr 2650 9 cells cell NNS cord-028721-x6f26ahr 2650 10 in in IN cord-028721-x6f26ahr 2650 11 47XXY 47xxy CD cord-028721-x6f26ahr 2650 12 fetuses fetus NNS cord-028721-x6f26ahr 2650 13 is be VBZ cord-028721-x6f26ahr 2650 14 signifi signifi NNP cord-028721-x6f26ahr 2650 15 cantly cantly RB cord-028721-x6f26ahr 2650 16 lower low JJR cord-028721-x6f26ahr 2650 17 than than IN cord-028721-x6f26ahr 2650 18 in in IN cord-028721-x6f26ahr 2650 19 normal normal JJ cord-028721-x6f26ahr 2650 20 46XY 46xy CD cord-028721-x6f26ahr 2650 21 fetuses fetus NNS cord-028721-x6f26ahr 2650 22 . . . cord-028721-x6f26ahr 2651 1 The the DT cord-028721-x6f26ahr 2651 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 2651 3 tubules tubule NNS cord-028721-x6f26ahr 2651 4 have have VBP cord-028721-x6f26ahr 2651 5 reduced reduce VBN cord-028721-x6f26ahr 2651 6 diameter diameter NN cord-028721-x6f26ahr 2651 7 , , , cord-028721-x6f26ahr 2651 8 particularly particularly RB cord-028721-x6f26ahr 2651 9 those those DT cord-028721-x6f26ahr 2651 10 devoid devoid JJ cord-028721-x6f26ahr 2651 11 of of IN cord-028721-x6f26ahr 2651 12 germ germ NN cord-028721-x6f26ahr 2651 13 cells cell NNS cord-028721-x6f26ahr 2651 14 . . . cord-028721-x6f26ahr 2652 1 The the DT cord-028721-x6f26ahr 2652 2 number number NN cord-028721-x6f26ahr 2652 3 of of IN cord-028721-x6f26ahr 2652 4 Sertoli sertoli JJ cord-028721-x6f26ahr 2652 5 cells cell NNS cord-028721-x6f26ahr 2652 6 per per IN cord-028721-x6f26ahr 2652 7 cross cross JJ cord-028721-x6f26ahr 2652 8 - - JJ cord-028721-x6f26ahr 2652 9 sectioned sectioned JJ cord-028721-x6f26ahr 2652 10 tubule tubule NN cord-028721-x6f26ahr 2652 11 is be VBZ cord-028721-x6f26ahr 2652 12 reduced reduce VBN cord-028721-x6f26ahr 2652 13 . . . cord-028721-x6f26ahr 2653 1 Megatubules Megatubules NNP cord-028721-x6f26ahr 2653 2 , , , cord-028721-x6f26ahr 2653 3 ring ring NN cord-028721-x6f26ahr 2653 4 - - HYPH cord-028721-x6f26ahr 2653 5 shaped shape VBN cord-028721-x6f26ahr 2653 6 tubules tubule NNS cord-028721-x6f26ahr 2653 7 , , , cord-028721-x6f26ahr 2653 8 and and CC cord-028721-x6f26ahr 2653 9 intratubular intratubular JJ cord-028721-x6f26ahr 2653 10 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 2653 11 bodies body NNS cord-028721-x6f26ahr 2653 12 are be VBP cord-028721-x6f26ahr 2653 13 common common JJ cord-028721-x6f26ahr 2653 14 ( ( -LRB- cord-028721-x6f26ahr 2653 15 Fig Fig NNP cord-028721-x6f26ahr 2653 16 . . . cord-028721-x6f26ahr 2653 17 12 12 CD cord-028721-x6f26ahr 2653 18 - - SYM cord-028721-x6f26ahr 2653 19 129 129 CD cord-028721-x6f26ahr 2653 20 ) ) -RRB- cord-028721-x6f26ahr 2653 21 . . . cord-028721-x6f26ahr 2654 1 In in IN cord-028721-x6f26ahr 2654 2 some some DT cord-028721-x6f26ahr 2654 3 cases case NNS cord-028721-x6f26ahr 2654 4 of of IN cord-028721-x6f26ahr 2654 5 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2654 6 's 's POS cord-028721-x6f26ahr 2654 7 syndrome syndrome NN cord-028721-x6f26ahr 2654 8 associated associate VBN cord-028721-x6f26ahr 2654 9 with with IN cord-028721-x6f26ahr 2654 10 Down Down NNP cord-028721-x6f26ahr 2654 11 's 's POS cord-028721-x6f26ahr 2654 12 syndrome syndrome NN cord-028721-x6f26ahr 2654 13 , , , cord-028721-x6f26ahr 2654 14 tubular tubular JJ cord-028721-x6f26ahr 2654 15 hyalinization hyalinization NN cord-028721-x6f26ahr 2654 16 is be VBZ cord-028721-x6f26ahr 2654 17 observed observe VBN cord-028721-x6f26ahr 2654 18 in in IN cord-028721-x6f26ahr 2654 19 childhood childhood NN cord-028721-x6f26ahr 2654 20 . . . cord-028721-x6f26ahr 2655 1 1129 1129 CD cord-028721-x6f26ahr 2656 1 The the DT cord-028721-x6f26ahr 2656 2 interstitium interstitium NN cord-028721-x6f26ahr 2656 3 is be VBZ cord-028721-x6f26ahr 2656 4 wide wide JJ cord-028721-x6f26ahr 2656 5 and and CC cord-028721-x6f26ahr 2656 6 contains contain VBZ cord-028721-x6f26ahr 2656 7 few few JJ cord-028721-x6f26ahr 2656 8 Leydig Leydig NNP cord-028721-x6f26ahr 2656 9 cell cell NN cord-028721-x6f26ahr 2656 10 precursors precursor NNS cord-028721-x6f26ahr 2656 11 . . . cord-028721-x6f26ahr 2657 1 If if IN cord-028721-x6f26ahr 2657 2 one one CD cord-028721-x6f26ahr 2657 3 testis testis NN cord-028721-x6f26ahr 2657 4 is be VBZ cord-028721-x6f26ahr 2657 5 undescended undescended JJ cord-028721-x6f26ahr 2657 6 , , , cord-028721-x6f26ahr 2657 7 its -PRON- PRP$ cord-028721-x6f26ahr 2657 8 histology histology NN cord-028721-x6f26ahr 2657 9 does do VBZ cord-028721-x6f26ahr 2657 10 not not RB cord-028721-x6f26ahr 2657 11 differ differ VB cord-028721-x6f26ahr 2657 12 from from IN cord-028721-x6f26ahr 2657 13 that that DT cord-028721-x6f26ahr 2657 14 of of IN cord-028721-x6f26ahr 2657 15 the the DT cord-028721-x6f26ahr 2657 16 contralateral contralateral JJ cord-028721-x6f26ahr 2657 17 testis testis NN cord-028721-x6f26ahr 2657 18 . . . cord-028721-x6f26ahr 2658 1 The the DT cord-028721-x6f26ahr 2658 2 testicular testicular NN cord-028721-x6f26ahr 2658 3 pattern pattern NN cord-028721-x6f26ahr 2658 4 remains remain VBZ cord-028721-x6f26ahr 2658 5 constant constant JJ cord-028721-x6f26ahr 2658 6 through through IN cord-028721-x6f26ahr 2658 7 childhood childhood NN cord-028721-x6f26ahr 2658 8 . . . cord-028721-x6f26ahr 2659 1 1130 1130 CD cord-028721-x6f26ahr 2660 1 At at IN cord-028721-x6f26ahr 2660 2 puberty puberty NN cord-028721-x6f26ahr 2660 3 , , , cord-028721-x6f26ahr 2660 4 before before IN cord-028721-x6f26ahr 2660 5 maturation maturation NN cord-028721-x6f26ahr 2660 6 of of IN cord-028721-x6f26ahr 2660 7 the the DT cord-028721-x6f26ahr 2660 8 tunica tunica NNP cord-028721-x6f26ahr 2660 9 propria propria NNP cord-028721-x6f26ahr 2660 10 occurs occur VBZ cord-028721-x6f26ahr 2660 11 , , , cord-028721-x6f26ahr 2660 12 the the DT cord-028721-x6f26ahr 2660 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 2660 14 tubules tubule NNS cord-028721-x6f26ahr 2660 15 rapidly rapidly RB cord-028721-x6f26ahr 2660 16 hyalinize hyalinize NNP cord-028721-x6f26ahr 2660 17 and and CC cord-028721-x6f26ahr 2660 18 Leydig Leydig NNP cord-028721-x6f26ahr 2660 19 cell cell NN cord-028721-x6f26ahr 2660 20 precursors precursor NNS cord-028721-x6f26ahr 2660 21 differentiate differentiate VBP cord-028721-x6f26ahr 2660 22 into into IN cord-028721-x6f26ahr 2660 23 Leydig Leydig NNP cord-028721-x6f26ahr 2660 24 cells cell NNS cord-028721-x6f26ahr 2660 25 . . . cord-028721-x6f26ahr 2661 1 1131 1131 CD cord-028721-x6f26ahr 2661 2 Association Association NNP cord-028721-x6f26ahr 2661 3 of of IN cord-028721-x6f26ahr 2661 4 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2661 5 's 's POS cord-028721-x6f26ahr 2661 6 syndrome syndrome NN cord-028721-x6f26ahr 2661 7 with with IN cord-028721-x6f26ahr 2661 8 precocious precocious JJ cord-028721-x6f26ahr 2661 9 puberty puberty NN cord-028721-x6f26ahr 2662 1 Although although IN cord-028721-x6f26ahr 2662 2 precocious precocious JJ cord-028721-x6f26ahr 2662 3 puberty puberty NN cord-028721-x6f26ahr 2662 4 is be VBZ cord-028721-x6f26ahr 2662 5 not not RB cord-028721-x6f26ahr 2662 6 a a DT cord-028721-x6f26ahr 2662 7 characteristic characteristic JJ cord-028721-x6f26ahr 2662 8 fi fi NN cord-028721-x6f26ahr 2662 9 nding nding NN cord-028721-x6f26ahr 2662 10 in in IN cord-028721-x6f26ahr 2662 11 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2662 12 's 's POS cord-028721-x6f26ahr 2662 13 syndrome syndrome NN cord-028721-x6f26ahr 2662 14 , , , cord-028721-x6f26ahr 2662 15 karyotyping karyotype VBG cord-028721-x6f26ahr 2662 16 in in IN cord-028721-x6f26ahr 2662 17 older old JJR cord-028721-x6f26ahr 2662 18 boys boy NNS cord-028721-x6f26ahr 2662 19 with with IN cord-028721-x6f26ahr 2662 20 mental mental JJ cord-028721-x6f26ahr 2662 21 retardation retardation NN cord-028721-x6f26ahr 2662 22 , , , cord-028721-x6f26ahr 2662 23 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2662 24 , , , cord-028721-x6f26ahr 2662 25 small small JJ cord-028721-x6f26ahr 2662 26 testes testis NNS cord-028721-x6f26ahr 2662 27 , , , cord-028721-x6f26ahr 2662 28 and and CC cord-028721-x6f26ahr 2662 29 precocious precocious JJ cord-028721-x6f26ahr 2662 30 puberty puberty NN cord-028721-x6f26ahr 2662 31 is be VBZ cord-028721-x6f26ahr 2662 32 advisable advisable JJ cord-028721-x6f26ahr 2662 33 . . . cord-028721-x6f26ahr 2663 1 In in IN cord-028721-x6f26ahr 2663 2 most most JJS cord-028721-x6f26ahr 2663 3 cases case NNS cord-028721-x6f26ahr 2663 4 , , , cord-028721-x6f26ahr 2663 5 the the DT cord-028721-x6f26ahr 2663 6 cause cause NN cord-028721-x6f26ahr 2663 7 of of IN cord-028721-x6f26ahr 2663 8 precocious precocious JJ cord-028721-x6f26ahr 2663 9 puberty puberty NN cord-028721-x6f26ahr 2663 10 is be VBZ cord-028721-x6f26ahr 2663 11 a a DT cord-028721-x6f26ahr 2663 12 hCG hcg NN cord-028721-x6f26ahr 2663 13 - - HYPH cord-028721-x6f26ahr 2663 14 secreting secrete VBG cord-028721-x6f26ahr 2663 15 germ germ NN cord-028721-x6f26ahr 2663 16 cell cell NN cord-028721-x6f26ahr 2663 17 tumor tumor NN cord-028721-x6f26ahr 2663 18 in in IN cord-028721-x6f26ahr 2663 19 the the DT cord-028721-x6f26ahr 2663 20 mediastinum mediastinum NN cord-028721-x6f26ahr 2663 21 . . . cord-028721-x6f26ahr 2664 1 1132 1132 CD cord-028721-x6f26ahr 2665 1 Infrequently infrequently RB cord-028721-x6f26ahr 2665 2 , , , cord-028721-x6f26ahr 2665 3 precocious precocious JJ cord-028721-x6f26ahr 2665 4 puberty puberty NN cord-028721-x6f26ahr 2665 5 is be VBZ cord-028721-x6f26ahr 2665 6 idiopathic idiopathic JJ cord-028721-x6f26ahr 2665 7 , , , cord-028721-x6f26ahr 2665 8 and and CC cord-028721-x6f26ahr 2665 9 only only RB cord-028721-x6f26ahr 2665 10 in in IN cord-028721-x6f26ahr 2665 11 isolated isolate VBN cord-028721-x6f26ahr 2665 12 cases case NNS cord-028721-x6f26ahr 2665 13 is be VBZ cord-028721-x6f26ahr 2665 14 there there EX cord-028721-x6f26ahr 2665 15 a a DT cord-028721-x6f26ahr 2665 16 hamartoma hamartoma NN cord-028721-x6f26ahr 2665 17 in in IN cord-028721-x6f26ahr 2665 18 the the DT cord-028721-x6f26ahr 2665 19 third third JJ cord-028721-x6f26ahr 2665 20 ventricle ventricle NN cord-028721-x6f26ahr 2665 21 . . . cord-028721-x6f26ahr 2666 1 1133 1133 CD cord-028721-x6f26ahr 2666 2 _SP cord-028721-x6f26ahr 2667 1 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2667 2 's 's POS cord-028721-x6f26ahr 2667 3 syndrome syndrome NN cord-028721-x6f26ahr 2667 4 is be VBZ cord-028721-x6f26ahr 2667 5 often often RB cord-028721-x6f26ahr 2667 6 associated associate VBN cord-028721-x6f26ahr 2667 7 with with IN cord-028721-x6f26ahr 2667 8 pituitary pituitary JJ cord-028721-x6f26ahr 2667 9 disorders disorder NNS cord-028721-x6f26ahr 2667 10 such such JJ cord-028721-x6f26ahr 2667 11 as as IN cord-028721-x6f26ahr 2667 12 panhypopituitarism panhypopituitarism NN cord-028721-x6f26ahr 2667 13 1134 1134 CD cord-028721-x6f26ahr 2667 14 or or CC cord-028721-x6f26ahr 2667 15 incomplete incomplete JJ cord-028721-x6f26ahr 2667 16 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 2667 17 . . . cord-028721-x6f26ahr 2668 1 1135 1135 CD cord-028721-x6f26ahr 2668 2 Defi Defi NNP cord-028721-x6f26ahr 2668 3 cits cit NNS cord-028721-x6f26ahr 2668 4 in in IN cord-028721-x6f26ahr 2668 5 FSH fsh NN cord-028721-x6f26ahr 2668 6 , , , cord-028721-x6f26ahr 2668 7 1136 1136 CD cord-028721-x6f26ahr 2668 8 LH lh NN cord-028721-x6f26ahr 2668 9 , , , cord-028721-x6f26ahr 2668 10 1137 1137 CD cord-028721-x6f26ahr 2668 11 or or CC cord-028721-x6f26ahr 2668 12 both both DT cord-028721-x6f26ahr 2668 13 1138 1138 CD cord-028721-x6f26ahr 2668 14 , , , cord-028721-x6f26ahr 2668 15 1139 1139 CD cord-028721-x6f26ahr 2668 16 have have VBP cord-028721-x6f26ahr 2668 17 been be VBN cord-028721-x6f26ahr 2668 18 reported report VBN cord-028721-x6f26ahr 2668 19 . . . cord-028721-x6f26ahr 2669 1 The the DT cord-028721-x6f26ahr 2669 2 cause cause NN cord-028721-x6f26ahr 2669 3 of of IN cord-028721-x6f26ahr 2669 4 this this DT cord-028721-x6f26ahr 2669 5 association association NN cord-028721-x6f26ahr 2669 6 is be VBZ cord-028721-x6f26ahr 2669 7 unknown unknown JJ cord-028721-x6f26ahr 2669 8 , , , cord-028721-x6f26ahr 2669 9 and and CC cord-028721-x6f26ahr 2669 10 diverse diverse JJ cord-028721-x6f26ahr 2669 11 etiologies etiology NNS cord-028721-x6f26ahr 2669 12 such such JJ cord-028721-x6f26ahr 2669 13 as as IN cord-028721-x6f26ahr 2669 14 trauma trauma NN cord-028721-x6f26ahr 2669 15 , , , cord-028721-x6f26ahr 2669 16 immunologic immunologic JJ cord-028721-x6f26ahr 2669 17 disorders disorder NNS cord-028721-x6f26ahr 2669 18 , , , cord-028721-x6f26ahr 2669 19 and and CC cord-028721-x6f26ahr 2669 20 genetic genetic JJ cord-028721-x6f26ahr 2669 21 defi defi NN cord-028721-x6f26ahr 2669 22 ciencies ciencie NNS cord-028721-x6f26ahr 2669 23 have have VBP cord-028721-x6f26ahr 2669 24 been be VBN cord-028721-x6f26ahr 2669 25 postulated postulate VBN cord-028721-x6f26ahr 2669 26 . . . cord-028721-x6f26ahr 2670 1 Alternatively alternatively RB cord-028721-x6f26ahr 2670 2 , , , cord-028721-x6f26ahr 2670 3 it -PRON- PRP cord-028721-x6f26ahr 2670 4 may may MD cord-028721-x6f26ahr 2670 5 be be VB cord-028721-x6f26ahr 2670 6 due due JJ cord-028721-x6f26ahr 2670 7 to to IN cord-028721-x6f26ahr 2670 8 exhaustion exhaustion NN cord-028721-x6f26ahr 2670 9 of of IN cord-028721-x6f26ahr 2670 10 pituitary pituitary JJ cord-028721-x6f26ahr 2670 11 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2670 12 - - HYPH cord-028721-x6f26ahr 2670 13 secreting secrete VBG cord-028721-x6f26ahr 2670 14 cells cell NNS cord-028721-x6f26ahr 2670 15 after after IN cord-028721-x6f26ahr 2670 16 years year NNS cord-028721-x6f26ahr 2670 17 of of IN cord-028721-x6f26ahr 2670 18 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2670 19 - - HYPH cord-028721-x6f26ahr 2670 20 releasing release VBG cord-028721-x6f26ahr 2670 21 hormone hormone NN cord-028721-x6f26ahr 2670 22 stimulation stimulation NN cord-028721-x6f26ahr 2670 23 . . . cord-028721-x6f26ahr 2671 1 1135 1135 CD cord-028721-x6f26ahr 2672 1 In in IN cord-028721-x6f26ahr 2672 2 patients patient NNS cord-028721-x6f26ahr 2672 3 defi defi NNP cord-028721-x6f26ahr 2672 4 cient cient NNP cord-028721-x6f26ahr 2672 5 in in IN cord-028721-x6f26ahr 2672 6 both both DT cord-028721-x6f26ahr 2672 7 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 2672 8 , , , cord-028721-x6f26ahr 2672 9 testicular testicular JJ cord-028721-x6f26ahr 2672 10 biopsy biopsy NN cord-028721-x6f26ahr 2672 11 shows show NNS cord-028721-x6f26ahr 2672 12 diffuse diffuse VBP cord-028721-x6f26ahr 2672 13 tubular tubular JJ cord-028721-x6f26ahr 2672 14 hyalinization hyalinization NN cord-028721-x6f26ahr 2672 15 and and CC cord-028721-x6f26ahr 2672 16 a a DT cord-028721-x6f26ahr 2672 17 marked marked JJ cord-028721-x6f26ahr 2672 18 reduction reduction NN cord-028721-x6f26ahr 2672 19 in in IN cord-028721-x6f26ahr 2672 20 or or CC cord-028721-x6f26ahr 2672 21 absence absence NN cord-028721-x6f26ahr 2672 22 of of IN cord-028721-x6f26ahr 2672 23 Leydig leydig NN cord-028721-x6f26ahr 2672 24 cells cell NNS cord-028721-x6f26ahr 2672 25 . . . cord-028721-x6f26ahr 2673 1 The the DT cord-028721-x6f26ahr 2673 2 histological histological JJ cord-028721-x6f26ahr 2673 3 picture picture NN cord-028721-x6f26ahr 2673 4 is be VBZ cord-028721-x6f26ahr 2673 5 similar similar JJ cord-028721-x6f26ahr 2673 6 to to IN cord-028721-x6f26ahr 2673 7 that that DT cord-028721-x6f26ahr 2673 8 of of IN cord-028721-x6f26ahr 2673 9 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2673 10 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2673 11 occurring occur VBG cord-028721-x6f26ahr 2673 12 after after IN cord-028721-x6f26ahr 2673 13 puberty puberty NN cord-028721-x6f26ahr 2673 14 , , , cord-028721-x6f26ahr 2673 15 except except IN cord-028721-x6f26ahr 2673 16 for for IN cord-028721-x6f26ahr 2673 17 the the DT cord-028721-x6f26ahr 2673 18 presence presence NN cord-028721-x6f26ahr 2673 19 of of IN cord-028721-x6f26ahr 2673 20 isolated isolate VBN cord-028721-x6f26ahr 2673 21 tubules tubule NNS cord-028721-x6f26ahr 2673 22 containing contain VBG cord-028721-x6f26ahr 2673 23 only only RB cord-028721-x6f26ahr 2673 24 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2673 25 Sertoli Sertoli NNP cord-028721-x6f26ahr 2673 26 cells cell NNS cord-028721-x6f26ahr 2673 27 and and CC cord-028721-x6f26ahr 2673 28 absence absence NN cord-028721-x6f26ahr 2673 29 of of IN cord-028721-x6f26ahr 2673 30 elastic elastic JJ cord-028721-x6f26ahr 2673 31 fi fi NN cord-028721-x6f26ahr 2673 32 bers ber NNS cord-028721-x6f26ahr 2673 33 in in IN cord-028721-x6f26ahr 2673 34 the the DT cord-028721-x6f26ahr 2673 35 hyalinized hyalinize VBN cord-028721-x6f26ahr 2673 36 tubular tubular JJ cord-028721-x6f26ahr 2673 37 wall wall NN cord-028721-x6f26ahr 2674 1 ( ( -LRB- cord-028721-x6f26ahr 2674 2 Fig Fig NNP cord-028721-x6f26ahr 2674 3 . . . cord-028721-x6f26ahr 2674 4 _SP cord-028721-x6f26ahr 2674 5 12 12 CD cord-028721-x6f26ahr 2674 6 - - SYM cord-028721-x6f26ahr 2674 7 130 130 CD cord-028721-x6f26ahr 2674 8 ) ) -RRB- cord-028721-x6f26ahr 2674 9 . . . cord-028721-x6f26ahr 2675 1 1139 1139 CD cord-028721-x6f26ahr 2675 2 Biopsy biopsy NN cord-028721-x6f26ahr 2675 3 of of IN cord-028721-x6f26ahr 2675 4 patients patient NNS cord-028721-x6f26ahr 2675 5 with with IN cord-028721-x6f26ahr 2675 6 a a DT cord-028721-x6f26ahr 2675 7 defi defi NNP cord-028721-x6f26ahr 2675 8 cit cit NN cord-028721-x6f26ahr 2675 9 only only RB cord-028721-x6f26ahr 2675 10 in in IN cord-028721-x6f26ahr 2675 11 FSH FSH NNP cord-028721-x6f26ahr 2675 12 is be VBZ cord-028721-x6f26ahr 2675 13 similar similar JJ cord-028721-x6f26ahr 2675 14 to to IN cord-028721-x6f26ahr 2675 15 that that DT cord-028721-x6f26ahr 2675 16 of of IN cord-028721-x6f26ahr 2675 17 the the DT cord-028721-x6f26ahr 2675 18 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 2675 19 Sertoli Sertoli NNP cord-028721-x6f26ahr 2675 20 cell cell NN cord-028721-x6f26ahr 2675 21 variant variant NN cord-028721-x6f26ahr 2675 22 of of IN cord-028721-x6f26ahr 2675 23 the the DT cord-028721-x6f26ahr 2675 24 Sertoli sertoli JJ cord-028721-x6f26ahr 2675 25 cell cell NN cord-028721-x6f26ahr 2675 26 - - HYPH cord-028721-x6f26ahr 2675 27 only only JJ cord-028721-x6f26ahr 2675 28 syndrome syndrome NN cord-028721-x6f26ahr 2675 29 , , , cord-028721-x6f26ahr 2675 30 although although IN cord-028721-x6f26ahr 2675 31 some some DT cord-028721-x6f26ahr 2675 32 hyalinized hyalinize VBN cord-028721-x6f26ahr 2675 33 tubules tubule NNS cord-028721-x6f26ahr 2675 34 are be VBP cord-028721-x6f26ahr 2675 35 present present JJ cord-028721-x6f26ahr 2675 36 . . . cord-028721-x6f26ahr 2676 1 The the DT cord-028721-x6f26ahr 2676 2 testicular testicular JJ cord-028721-x6f26ahr 2676 3 biopsy biopsy NN cord-028721-x6f26ahr 2676 4 of of IN cord-028721-x6f26ahr 2676 5 patients patient NNS cord-028721-x6f26ahr 2676 6 defi defi NNP cord-028721-x6f26ahr 2676 7 cient cient NNP cord-028721-x6f26ahr 2676 8 only only RB cord-028721-x6f26ahr 2676 9 in in IN cord-028721-x6f26ahr 2676 10 LH LH NNP cord-028721-x6f26ahr 2676 11 resembles resemble VBZ cord-028721-x6f26ahr 2676 12 that that DT cord-028721-x6f26ahr 2676 13 of of IN cord-028721-x6f26ahr 2676 14 men man NNS cord-028721-x6f26ahr 2676 15 with with IN cord-028721-x6f26ahr 2676 16 classic classic JJ cord-028721-x6f26ahr 2676 17 47XXY 47xxy CD cord-028721-x6f26ahr 2676 18 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2676 19 's 's POS cord-028721-x6f26ahr 2676 20 syndrome syndrome NN cord-028721-x6f26ahr 2676 21 . . . cord-028721-x6f26ahr 2677 1 46XX 46xx CD cord-028721-x6f26ahr 2677 2 males male NNS cord-028721-x6f26ahr 2678 1 The the DT cord-028721-x6f26ahr 2678 2 46XX 46xx CD cord-028721-x6f26ahr 2678 3 karyotype karyotype NN cord-028721-x6f26ahr 2678 4 may may MD cord-028721-x6f26ahr 2678 5 be be VB cord-028721-x6f26ahr 2678 6 present present JJ cord-028721-x6f26ahr 2678 7 in in IN cord-028721-x6f26ahr 2678 8 three three CD cord-028721-x6f26ahr 2678 9 phenotypes phenotype NNS cord-028721-x6f26ahr 2678 10 : : : cord-028721-x6f26ahr 2678 11 male male JJ cord-028721-x6f26ahr 2678 12 phenotype phenotype NN cord-028721-x6f26ahr 2678 13 , , , cord-028721-x6f26ahr 2678 14 including include VBG cord-028721-x6f26ahr 2678 15 normal normal JJ cord-028721-x6f26ahr 2678 16 external external JJ cord-028721-x6f26ahr 2678 17 genitalia genitalia NNS cord-028721-x6f26ahr 2678 18 ; ; : cord-028721-x6f26ahr 2678 19 male male JJ cord-028721-x6f26ahr 2678 20 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 2678 21 , , , cord-028721-x6f26ahr 2678 22 with with IN cord-028721-x6f26ahr 2678 23 a a DT cord-028721-x6f26ahr 2678 24 variable variable JJ cord-028721-x6f26ahr 2678 25 degree degree NN cord-028721-x6f26ahr 2678 26 of of IN cord-028721-x6f26ahr 2678 27 ambiguity ambiguity NN cord-028721-x6f26ahr 2678 28 in in IN cord-028721-x6f26ahr 2678 29 external external JJ cord-028721-x6f26ahr 2678 30 genitalia genitalia NNS cord-028721-x6f26ahr 2678 31 , , , cord-028721-x6f26ahr 2678 32 ranging range VBG cord-028721-x6f26ahr 2678 33 from from IN cord-028721-x6f26ahr 2678 34 hypospadias hypospadia NNS cord-028721-x6f26ahr 2678 35 to to IN cord-028721-x6f26ahr 2678 36 micropenis micropenis NN cord-028721-x6f26ahr 2678 37 ; ; : cord-028721-x6f26ahr 2678 38 and and CC cord-028721-x6f26ahr 2678 39 true true JJ cord-028721-x6f26ahr 2678 40 male male JJ cord-028721-x6f26ahr 2678 41 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 2678 42 . . . cord-028721-x6f26ahr 2679 1 46XX 46xx CD cord-028721-x6f26ahr 2679 2 males male NNS cord-028721-x6f26ahr 2679 3 with with IN cord-028721-x6f26ahr 2679 4 male male JJ cord-028721-x6f26ahr 2679 5 phenotype phenotype NN cord-028721-x6f26ahr 2679 6 and and CC cord-028721-x6f26ahr 2679 7 normal normal JJ cord-028721-x6f26ahr 2679 8 external external JJ cord-028721-x6f26ahr 2679 9 genitalia genitalia NNS cord-028721-x6f26ahr 2680 1 Men man NNS cord-028721-x6f26ahr 2680 2 with with IN cord-028721-x6f26ahr 2680 3 the the DT cord-028721-x6f26ahr 2680 4 46XX 46xx CD cord-028721-x6f26ahr 2680 5 karyotype karyotype NN cord-028721-x6f26ahr 2680 6 having have VBG cord-028721-x6f26ahr 2680 7 male male JJ cord-028721-x6f26ahr 2680 8 phenotype phenotype NN cord-028721-x6f26ahr 2680 9 and and CC cord-028721-x6f26ahr 2680 10 normal normal JJ cord-028721-x6f26ahr 2680 11 external external JJ cord-028721-x6f26ahr 2680 12 genitalia genitalia NNS cord-028721-x6f26ahr 2680 13 have have VBP cord-028721-x6f26ahr 2680 14 clinical clinical JJ cord-028721-x6f26ahr 2680 15 features feature NNS cord-028721-x6f26ahr 2680 16 similar similar JJ cord-028721-x6f26ahr 2680 17 to to IN cord-028721-x6f26ahr 2680 18 those those DT cord-028721-x6f26ahr 2680 19 of of IN cord-028721-x6f26ahr 2680 20 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2680 21 's 's POS cord-028721-x6f26ahr 2680 22 syndrome syndrome NN cord-028721-x6f26ahr 2680 23 , , , cord-028721-x6f26ahr 2680 24 including include VBG cord-028721-x6f26ahr 2680 25 small small JJ cord-028721-x6f26ahr 2680 26 testes testis NNS cord-028721-x6f26ahr 2680 27 , , , cord-028721-x6f26ahr 2680 28 small small JJ cord-028721-x6f26ahr 2680 29 or or CC cord-028721-x6f26ahr 2680 30 normal normal JJ cord-028721-x6f26ahr 2680 31 penis penis NN cord-028721-x6f26ahr 2680 32 , , , cord-028721-x6f26ahr 2680 33 azoospermia azoospermia NN cord-028721-x6f26ahr 2680 34 , , , cord-028721-x6f26ahr 2680 35 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2680 36 , , , cord-028721-x6f26ahr 2680 37 and and CC cord-028721-x6f26ahr 2680 38 minimal minimal JJ cord-028721-x6f26ahr 2680 39 development development NN cord-028721-x6f26ahr 2680 40 of of IN cord-028721-x6f26ahr 2680 41 secondary secondary JJ cord-028721-x6f26ahr 2680 42 sex sex NN cord-028721-x6f26ahr 2680 43 characteristics characteristic NNS cord-028721-x6f26ahr 2680 44 . . . cord-028721-x6f26ahr 2681 1 However however RB cord-028721-x6f26ahr 2681 2 , , , cord-028721-x6f26ahr 2681 3 these these DT cord-028721-x6f26ahr 2681 4 men man NNS cord-028721-x6f26ahr 2681 5 have have VBP cord-028721-x6f26ahr 2681 6 harmonious harmonious JJ cord-028721-x6f26ahr 2681 7 body body NN cord-028721-x6f26ahr 2681 8 proportions proportion NNS cord-028721-x6f26ahr 2681 9 , , , cord-028721-x6f26ahr 2681 10 normal normal JJ cord-028721-x6f26ahr 2681 11 or or CC cord-028721-x6f26ahr 2681 12 slightly slightly RB cord-028721-x6f26ahr 2681 13 low low JJ cord-028721-x6f26ahr 2681 14 stature stature NN cord-028721-x6f26ahr 2681 15 , , , cord-028721-x6f26ahr 2681 16 and and CC cord-028721-x6f26ahr 2681 17 normal normal JJ cord-028721-x6f26ahr 2681 18 intelligence intelligence NN cord-028721-x6f26ahr 2681 19 . . . cord-028721-x6f26ahr 2682 1 1140 1140 CD cord-028721-x6f26ahr 2683 1 The the DT cord-028721-x6f26ahr 2683 2 incidence incidence NN cord-028721-x6f26ahr 2683 3 of of IN cord-028721-x6f26ahr 2683 4 46XX 46xx CD cord-028721-x6f26ahr 2683 5 males male NNS cord-028721-x6f26ahr 2683 6 varies vary VBZ cord-028721-x6f26ahr 2683 7 from from IN cord-028721-x6f26ahr 2683 8 1 1 CD cord-028721-x6f26ahr 2683 9 : : SYM cord-028721-x6f26ahr 2683 10 10 10 CD cord-028721-x6f26ahr 2683 11 000 000 CD cord-028721-x6f26ahr 2683 12 to to IN cord-028721-x6f26ahr 2683 13 1 1 CD cord-028721-x6f26ahr 2683 14 : : : cord-028721-x6f26ahr 2683 15 25 25 CD cord-028721-x6f26ahr 2683 16 000 000 CD cord-028721-x6f26ahr 2683 17 live live JJ cord-028721-x6f26ahr 2683 18 births birth NNS cord-028721-x6f26ahr 2683 19 , , , cord-028721-x6f26ahr 2683 20 accounting account VBG cord-028721-x6f26ahr 2683 21 for for IN cord-028721-x6f26ahr 2683 22 about about RB cord-028721-x6f26ahr 2683 23 0.2 0.2 CD cord-028721-x6f26ahr 2683 24 % % NN cord-028721-x6f26ahr 2683 25 of of IN cord-028721-x6f26ahr 2683 26 infertile infertile JJ cord-028721-x6f26ahr 2683 27 men man NNS cord-028721-x6f26ahr 2683 28 . . . cord-028721-x6f26ahr 2684 1 1141 1141 CD cord-028721-x6f26ahr 2684 2 , , , cord-028721-x6f26ahr 2684 3 1142 1142 CD cord-028721-x6f26ahr 2684 4 Males male NNS cord-028721-x6f26ahr 2684 5 with with IN cord-028721-x6f26ahr 2684 6 46XX 46xx CD cord-028721-x6f26ahr 2684 7 karyotype karyotype NN cord-028721-x6f26ahr 2684 8 have have VBP cord-028721-x6f26ahr 2684 9 hypergonadotropic hypergonadotropic JJ cord-028721-x6f26ahr 2684 10 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2684 11 with with IN cord-028721-x6f26ahr 2684 12 elevated elevated JJ cord-028721-x6f26ahr 2684 13 serum serum NN cord-028721-x6f26ahr 2684 14 levels level NNS cord-028721-x6f26ahr 2684 15 of of IN cord-028721-x6f26ahr 2684 16 FSH fsh NN cord-028721-x6f26ahr 2684 17 and and CC cord-028721-x6f26ahr 2684 18 , , , cord-028721-x6f26ahr 2684 19 to to IN cord-028721-x6f26ahr 2684 20 a a DT cord-028721-x6f26ahr 2684 21 lesser less JJR cord-028721-x6f26ahr 2684 22 degree degree NN cord-028721-x6f26ahr 2684 23 , , , cord-028721-x6f26ahr 2684 24 elevated elevated JJ cord-028721-x6f26ahr 2684 25 LH lh NN cord-028721-x6f26ahr 2684 26 , , , cord-028721-x6f26ahr 2684 27 with with IN cord-028721-x6f26ahr 2684 28 normal normal JJ cord-028721-x6f26ahr 2684 29 or or CC cord-028721-x6f26ahr 2684 30 slightly slightly RB cord-028721-x6f26ahr 2684 31 decreased decrease VBD cord-028721-x6f26ahr 2684 32 testosterone testosterone NN cord-028721-x6f26ahr 2684 33 . . . cord-028721-x6f26ahr 2685 1 Familial familial JJ cord-028721-x6f26ahr 2685 2 cases case NNS cord-028721-x6f26ahr 2685 3 have have VBP cord-028721-x6f26ahr 2685 4 been be VBN cord-028721-x6f26ahr 2685 5 reported report VBN cord-028721-x6f26ahr 2685 6 . . . cord-028721-x6f26ahr 2686 1 1143 1143 CD cord-028721-x6f26ahr 2687 1 During during IN cord-028721-x6f26ahr 2687 2 childhood childhood NN cord-028721-x6f26ahr 2687 3 , , , cord-028721-x6f26ahr 2687 4 biopsy biopsy NN cord-028721-x6f26ahr 2687 5 of of IN cord-028721-x6f26ahr 2687 6 46XX 46xx CD cord-028721-x6f26ahr 2687 7 males male NNS cord-028721-x6f26ahr 2687 8 reveals reveal VBZ cord-028721-x6f26ahr 2687 9 decreased decrease VBD cord-028721-x6f26ahr 2687 10 numbers number NNS cord-028721-x6f26ahr 2687 11 of of IN cord-028721-x6f26ahr 2687 12 germ germ NN cord-028721-x6f26ahr 2687 13 cells cell NNS cord-028721-x6f26ahr 2687 14 . . . cord-028721-x6f26ahr 2688 1 1144 1144 CD cord-028721-x6f26ahr 2688 2 , , , cord-028721-x6f26ahr 2688 3 1145 1145 CD cord-028721-x6f26ahr 2688 4 Biopsies biopsy NNS cord-028721-x6f26ahr 2688 5 from from IN cord-028721-x6f26ahr 2688 6 adults adult NNS cord-028721-x6f26ahr 2688 7 show show VBP cord-028721-x6f26ahr 2688 8 one one CD cord-028721-x6f26ahr 2688 9 of of IN cord-028721-x6f26ahr 2688 10 three three CD cord-028721-x6f26ahr 2688 11 patterns pattern NNS cord-028721-x6f26ahr 2688 12 : : : cord-028721-x6f26ahr 2688 13 histology histology NN cord-028721-x6f26ahr 2688 14 similar similar JJ cord-028721-x6f26ahr 2688 15 to to IN cord-028721-x6f26ahr 2688 16 that that DT cord-028721-x6f26ahr 2688 17 of of IN cord-028721-x6f26ahr 2688 18 47XXY 47xxy CD cord-028721-x6f26ahr 2688 19 men man NNS cord-028721-x6f26ahr 2688 20 , , , cord-028721-x6f26ahr 2688 21 including include VBG cord-028721-x6f26ahr 2688 22 diffuse diffuse VBP cord-028721-x6f26ahr 2688 23 tubular tubular JJ cord-028721-x6f26ahr 2688 24 hyalinization hyalinization NN cord-028721-x6f26ahr 2688 25 with with IN cord-028721-x6f26ahr 2688 26 prominent prominent JJ cord-028721-x6f26ahr 2688 27 Leydig Leydig NNP cord-028721-x6f26ahr 2688 28 cells cell NNS cord-028721-x6f26ahr 2688 29 ; ; : cord-028721-x6f26ahr 2688 30 1146 1146 CD cord-028721-x6f26ahr 2688 31 Sertoli sertoli JJ cord-028721-x6f26ahr 2688 32 cell cell NN cord-028721-x6f26ahr 2688 33 - - HYPH cord-028721-x6f26ahr 2688 34 only only JJ cord-028721-x6f26ahr 2688 35 tubules tubule NNS cord-028721-x6f26ahr 2688 36 ; ; : cord-028721-x6f26ahr 2688 37 1147 1147 CD cord-028721-x6f26ahr 2688 38 , , , cord-028721-x6f26ahr 2688 39 1148 1148 CD cord-028721-x6f26ahr 2688 40 and and CC cord-028721-x6f26ahr 2688 41 both both DT cord-028721-x6f26ahr 2688 42 patterns pattern NNS cord-028721-x6f26ahr 2688 43 intermingled intermingle VBN cord-028721-x6f26ahr 2688 44 with with IN cord-028721-x6f26ahr 2688 45 less less RBR cord-028721-x6f26ahr 2688 46 prominent prominent JJ cord-028721-x6f26ahr 2688 47 Leydig Leydig NNP cord-028721-x6f26ahr 2688 48 cells cell NNS cord-028721-x6f26ahr 2688 49 . . . cord-028721-x6f26ahr 2689 1 The the DT cord-028721-x6f26ahr 2689 2 last last JJ cord-028721-x6f26ahr 2689 3 is be VBZ cord-028721-x6f26ahr 2689 4 the the DT cord-028721-x6f26ahr 2689 5 most most RBS cord-028721-x6f26ahr 2689 6 frequent frequent JJ cord-028721-x6f26ahr 2689 7 ( ( -LRB- cord-028721-x6f26ahr 2689 8 Fig Fig NNP cord-028721-x6f26ahr 2689 9 . . . cord-028721-x6f26ahr 2689 10 12 12 CD cord-028721-x6f26ahr 2689 11 - - SYM cord-028721-x6f26ahr 2689 12 131 131 CD cord-028721-x6f26ahr 2689 13 ) ) -RRB- cord-028721-x6f26ahr 2689 14 . . . cord-028721-x6f26ahr 2690 1 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 2690 2 studies study NNS cord-028721-x6f26ahr 2690 3 reveal reveal VBP cord-028721-x6f26ahr 2690 4 an an DT cord-028721-x6f26ahr 2690 5 increase increase NN cord-028721-x6f26ahr 2690 6 in in IN cord-028721-x6f26ahr 2690 7 intermediate intermediate JJ cord-028721-x6f26ahr 2690 8 fi fi NN cord-028721-x6f26ahr 2690 9 laments lament NNS cord-028721-x6f26ahr 2690 10 , , , cord-028721-x6f26ahr 2690 11 absence absence NN cord-028721-x6f26ahr 2690 12 of of IN cord-028721-x6f26ahr 2690 13 annulate annulate NN cord-028721-x6f26ahr 2690 14 lamellae lamella NNS cord-028721-x6f26ahr 2690 15 in in IN cord-028721-x6f26ahr 2690 16 Sertoli Sertoli NNP cord-028721-x6f26ahr 2690 17 cells cell NNS cord-028721-x6f26ahr 2690 18 , , , cord-028721-x6f26ahr 2690 19 1149 1149 CD cord-028721-x6f26ahr 2690 20 absence absence NN cord-028721-x6f26ahr 2690 21 of of IN cord-028721-x6f26ahr 2690 22 Reinke Reinke NNP cord-028721-x6f26ahr 2690 23 's 's POS cord-028721-x6f26ahr 2690 24 crystalloids crystalloid NNS cord-028721-x6f26ahr 2690 25 , , , cord-028721-x6f26ahr 2690 26 and and CC cord-028721-x6f26ahr 2690 27 abundance abundance NN cord-028721-x6f26ahr 2690 28 of of IN cord-028721-x6f26ahr 2690 29 intracytoplasmic intracytoplasmic NNP cord-028721-x6f26ahr 2690 30 and and CC cord-028721-x6f26ahr 2690 31 intranuclear intranuclear NNP cord-028721-x6f26ahr 2690 32 paracrystalline paracrystalline NNP cord-028721-x6f26ahr 2690 33 inclusions inclusion NNS cord-028721-x6f26ahr 2690 34 in in IN cord-028721-x6f26ahr 2690 35 Leydig leydig NN cord-028721-x6f26ahr 2690 36 cells cell NNS cord-028721-x6f26ahr 2690 37 . . . cord-028721-x6f26ahr 2691 1 1147 1147 CD cord-028721-x6f26ahr 2691 2 46XX 46xx CD cord-028721-x6f26ahr 2691 3 males male NNS cord-028721-x6f26ahr 2691 4 with with IN cord-028721-x6f26ahr 2691 5 ambiguous ambiguous JJ cord-028721-x6f26ahr 2691 6 external external JJ cord-028721-x6f26ahr 2691 7 genitalia genitalia NNS cord-028721-x6f26ahr 2692 1 Some some DT cord-028721-x6f26ahr 2692 2 patients patient NNS cord-028721-x6f26ahr 2692 3 with with IN cord-028721-x6f26ahr 2692 4 the the DT cord-028721-x6f26ahr 2692 5 46XX 46xx CD cord-028721-x6f26ahr 2692 6 karyotype karyotype NN cord-028721-x6f26ahr 2692 7 have have VBP cord-028721-x6f26ahr 2692 8 ambiguous ambiguous JJ cord-028721-x6f26ahr 2692 9 external external JJ cord-028721-x6f26ahr 2692 10 genitalia genitalia NNS cord-028721-x6f26ahr 2692 11 or or CC cord-028721-x6f26ahr 2692 12 hypospadias hypospadia NNS cord-028721-x6f26ahr 2692 13 and and CC cord-028721-x6f26ahr 2692 14 are be VBP cord-028721-x6f26ahr 2692 15 assumed assume VBN cord-028721-x6f26ahr 2692 16 to to TO cord-028721-x6f26ahr 2692 17 have have VB cord-028721-x6f26ahr 2692 18 a a DT cord-028721-x6f26ahr 2692 19 variation variation NN cord-028721-x6f26ahr 2692 20 of of IN cord-028721-x6f26ahr 2692 21 male male JJ cord-028721-x6f26ahr 2692 22 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 2692 23 . . . cord-028721-x6f26ahr 2693 1 1150 1150 CD cord-028721-x6f26ahr 2694 1 These these DT cord-028721-x6f26ahr 2694 2 males male NNS cord-028721-x6f26ahr 2694 3 , , , cord-028721-x6f26ahr 2694 4 together together RB cord-028721-x6f26ahr 2694 5 with with IN cord-028721-x6f26ahr 2694 6 true true JJ cord-028721-x6f26ahr 2694 7 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 2694 8 , , , cord-028721-x6f26ahr 2694 9 may may MD cord-028721-x6f26ahr 2694 10 be be VB cord-028721-x6f26ahr 2694 11 found find VBN cord-028721-x6f26ahr 2694 12 in in IN cord-028721-x6f26ahr 2694 13 the the DT cord-028721-x6f26ahr 2694 14 same same JJ cord-028721-x6f26ahr 2694 15 family family NN cord-028721-x6f26ahr 2694 16 , , , cord-028721-x6f26ahr 2694 17 suggesting suggest VBG cord-028721-x6f26ahr 2694 18 that that IN cord-028721-x6f26ahr 2694 19 both both DT cord-028721-x6f26ahr 2694 20 disorders disorder NNS cord-028721-x6f26ahr 2694 21 are be VBP cord-028721-x6f26ahr 2694 22 different different JJ cord-028721-x6f26ahr 2694 23 manifestations manifestation NNS cord-028721-x6f26ahr 2694 24 of of IN cord-028721-x6f26ahr 2694 25 the the DT cord-028721-x6f26ahr 2694 26 same same JJ cord-028721-x6f26ahr 2694 27 genetic genetic JJ cord-028721-x6f26ahr 2694 28 defect defect NN cord-028721-x6f26ahr 2694 29 . . . cord-028721-x6f26ahr 2695 1 The the DT cord-028721-x6f26ahr 2695 2 origin origin NN cord-028721-x6f26ahr 2695 3 of of IN cord-028721-x6f26ahr 2695 4 46XX 46xx CD cord-028721-x6f26ahr 2695 5 males male NNS cord-028721-x6f26ahr 2695 6 may may MD cord-028721-x6f26ahr 2695 7 be be VB cord-028721-x6f26ahr 2695 8 diffi diffi JJ cord-028721-x6f26ahr 2695 9 cult cult NN cord-028721-x6f26ahr 2695 10 to to TO cord-028721-x6f26ahr 2695 11 determine determine VB cord-028721-x6f26ahr 2695 12 . . . cord-028721-x6f26ahr 2696 1 However however RB cord-028721-x6f26ahr 2696 2 , , , cord-028721-x6f26ahr 2696 3 as as IN cord-028721-x6f26ahr 2696 4 testicular testicular JJ cord-028721-x6f26ahr 2696 5 differentiation differentiation NN cord-028721-x6f26ahr 2696 6 requires require VBZ cord-028721-x6f26ahr 2696 7 genes gene NNS cord-028721-x6f26ahr 2696 8 located locate VBN cord-028721-x6f26ahr 2696 9 on on IN cord-028721-x6f26ahr 2696 10 the the DT cord-028721-x6f26ahr 2696 11 Y Y NNP cord-028721-x6f26ahr 2696 12 chromosome chromosome NN cord-028721-x6f26ahr 2696 13 , , , cord-028721-x6f26ahr 2696 14 46XX 46xx CD cord-028721-x6f26ahr 2696 15 males male NNS cord-028721-x6f26ahr 2696 16 have have VBP cord-028721-x6f26ahr 2696 17 been be VBN cord-028721-x6f26ahr 2696 18 classifi classifi NNP cord-028721-x6f26ahr 2696 19 ed ed NNP cord-028721-x6f26ahr 2696 20 by by IN cord-028721-x6f26ahr 2696 21 cytogenetics cytogenetic NNS cord-028721-x6f26ahr 2696 22 as as IN cord-028721-x6f26ahr 2696 23 those those DT cord-028721-x6f26ahr 2696 24 having have VBG cord-028721-x6f26ahr 2696 25 the the DT cord-028721-x6f26ahr 2696 26 SRY SRY NNP cord-028721-x6f26ahr 2696 27 gene gene NN cord-028721-x6f26ahr 2696 28 , , , cord-028721-x6f26ahr 2696 29 those those DT cord-028721-x6f26ahr 2696 30 lacking lack VBG cord-028721-x6f26ahr 2696 31 the the DT cord-028721-x6f26ahr 2696 32 SRY SRY NNP cord-028721-x6f26ahr 2696 33 gene gene NN cord-028721-x6f26ahr 2696 34 , , , cord-028721-x6f26ahr 2696 35 and and CC cord-028721-x6f26ahr 2696 36 XX XX NNP cord-028721-x6f26ahr 2696 37 / / SYM cord-028721-x6f26ahr 2696 38 XY XY NNP cord-028721-x6f26ahr 2696 39 mosaicism mosaicism NN cord-028721-x6f26ahr 2696 40 . . . cord-028721-x6f26ahr 2697 1 Males male NNS cord-028721-x6f26ahr 2697 2 with with IN cord-028721-x6f26ahr 2697 3 the the DT cord-028721-x6f26ahr 2697 4 SRY SRY NNP cord-028721-x6f26ahr 2697 5 gene gene NN cord-028721-x6f26ahr 2697 6 comprise comprise VBP cord-028721-x6f26ahr 2697 7 80 80 CD cord-028721-x6f26ahr 2697 8 % % NN cord-028721-x6f26ahr 2697 9 of of IN cord-028721-x6f26ahr 2697 10 46XX 46xx CD cord-028721-x6f26ahr 2697 11 males male NNS cord-028721-x6f26ahr 2697 12 . . . cord-028721-x6f26ahr 2698 1 1151 1151 CD cord-028721-x6f26ahr 2699 1 It -PRON- PRP cord-028721-x6f26ahr 2699 2 is be VBZ cord-028721-x6f26ahr 2699 3 likely likely JJ cord-028721-x6f26ahr 2699 4 that that IN cord-028721-x6f26ahr 2699 5 this this DT cord-028721-x6f26ahr 2699 6 occurs occur VBZ cord-028721-x6f26ahr 2699 7 when when WRB cord-028721-x6f26ahr 2699 8 the the DT cord-028721-x6f26ahr 2699 9 genetic genetic JJ cord-028721-x6f26ahr 2699 10 material material NN cord-028721-x6f26ahr 2699 11 from from IN cord-028721-x6f26ahr 2699 12 Infertility Infertility NNP cord-028721-x6f26ahr 2699 13 the the DT cord-028721-x6f26ahr 2699 14 short short JJ cord-028721-x6f26ahr 2699 15 arm arm NN cord-028721-x6f26ahr 2699 16 of of IN cord-028721-x6f26ahr 2699 17 the the DT cord-028721-x6f26ahr 2699 18 Y Y NNP cord-028721-x6f26ahr 2699 19 chromosome chromosome NN cord-028721-x6f26ahr 2699 20 is be VBZ cord-028721-x6f26ahr 2699 21 translocated translocate VBN cord-028721-x6f26ahr 2699 22 to to IN cord-028721-x6f26ahr 2699 23 the the DT cord-028721-x6f26ahr 2699 24 X x NN cord-028721-x6f26ahr 2699 25 chromosome chromosome NN cord-028721-x6f26ahr 2699 26 . . . cord-028721-x6f26ahr 2700 1 1152 1152 CD cord-028721-x6f26ahr 2701 1 During during IN cord-028721-x6f26ahr 2701 2 paternal paternal JJ cord-028721-x6f26ahr 2701 3 meiosis meiosis NN cord-028721-x6f26ahr 2701 4 , , , cord-028721-x6f26ahr 2701 5 the the DT cord-028721-x6f26ahr 2701 6 homolog homolog NN cord-028721-x6f26ahr 2701 7 pseudoautosomal pseudoautosomal NN cord-028721-x6f26ahr 2701 8 regions region NNS cord-028721-x6f26ahr 2701 9 of of IN cord-028721-x6f26ahr 2701 10 chromosomes chromosome NNS cord-028721-x6f26ahr 2701 11 X X NNP cord-028721-x6f26ahr 2701 12 and and CC cord-028721-x6f26ahr 2701 13 Y Y NNP cord-028721-x6f26ahr 2701 14 interchange interchange VBP cord-028721-x6f26ahr 2701 15 the the DT cord-028721-x6f26ahr 2701 16 terminal terminal JJ cord-028721-x6f26ahr 2701 17 portions portion NNS cord-028721-x6f26ahr 2701 18 of of IN cord-028721-x6f26ahr 2701 19 their -PRON- PRP$ cord-028721-x6f26ahr 2701 20 short short JJ cord-028721-x6f26ahr 2701 21 arms arm NNS cord-028721-x6f26ahr 2701 22 , , , cord-028721-x6f26ahr 2701 23 giving give VBG cord-028721-x6f26ahr 2701 24 rise rise NN cord-028721-x6f26ahr 2701 25 to to IN cord-028721-x6f26ahr 2701 26 an an DT cord-028721-x6f26ahr 2701 27 X x NN cord-028721-x6f26ahr 2701 28 chromosome chromosome NN cord-028721-x6f26ahr 2701 29 with with IN cord-028721-x6f26ahr 2701 30 the the DT cord-028721-x6f26ahr 2701 31 SRY SRY NNP cord-028721-x6f26ahr 2701 32 gene gene NN cord-028721-x6f26ahr 2701 33 but but CC cord-028721-x6f26ahr 2701 34 lacking lack VBG cord-028721-x6f26ahr 2701 35 the the DT cord-028721-x6f26ahr 2701 36 azoospermia azoospermia NN cord-028721-x6f26ahr 2701 37 factor factor NN cord-028721-x6f26ahr 2701 38 . . . cord-028721-x6f26ahr 2702 1 [ [ -LRB- cord-028721-x6f26ahr 2702 2 1153 1153 CD cord-028721-x6f26ahr 2702 3 ] ] -RRB- cord-028721-x6f26ahr 2702 4 [ [ -LRB- cord-028721-x6f26ahr 2702 5 1154 1154 CD cord-028721-x6f26ahr 2702 6 ] ] -RRB- cord-028721-x6f26ahr 2702 7 [ [ -LRB- cord-028721-x6f26ahr 2702 8 1155 1155 CD cord-028721-x6f26ahr 2702 9 ] ] -RRB- cord-028721-x6f26ahr 2703 1 [ [ -LRB- cord-028721-x6f26ahr 2703 2 1156 1156 CD cord-028721-x6f26ahr 2703 3 ] ] -RRB- cord-028721-x6f26ahr 2703 4 [ [ -LRB- cord-028721-x6f26ahr 2703 5 1157 1157 CD cord-028721-x6f26ahr 2703 6 ] ] -RRB- cord-028721-x6f26ahr 2704 1 [ [ -LRB- cord-028721-x6f26ahr 2704 2 1158 1158 CD cord-028721-x6f26ahr 2704 3 ] ] -RRB- cord-028721-x6f26ahr 2705 1 Alternatively alternatively RB cord-028721-x6f26ahr 2705 2 , , , cord-028721-x6f26ahr 2705 3 the the DT cord-028721-x6f26ahr 2705 4 SRY SRY NNP cord-028721-x6f26ahr 2705 5 region region NN cord-028721-x6f26ahr 2705 6 may may MD cord-028721-x6f26ahr 2705 7 be be VB cord-028721-x6f26ahr 2705 8 inserted insert VBN cord-028721-x6f26ahr 2705 9 in in IN cord-028721-x6f26ahr 2705 10 an an DT cord-028721-x6f26ahr 2705 11 autosome autosome NN cord-028721-x6f26ahr 2705 12 . . . cord-028721-x6f26ahr 2706 1 1159 1159 CD cord-028721-x6f26ahr 2707 1 Most Most JJS cord-028721-x6f26ahr 2707 2 46XX 46xx CD cord-028721-x6f26ahr 2707 3 patients patient NNS cord-028721-x6f26ahr 2707 4 who who WP cord-028721-x6f26ahr 2707 5 are be VBP cord-028721-x6f26ahr 2707 6 SRY sry UH cord-028721-x6f26ahr 2707 7 positive positive JJ cord-028721-x6f26ahr 2707 8 have have VBP cord-028721-x6f26ahr 2707 9 a a DT cord-028721-x6f26ahr 2707 10 normal normal JJ cord-028721-x6f26ahr 2707 11 male male JJ cord-028721-x6f26ahr 2707 12 phenotype phenotype NN cord-028721-x6f26ahr 2707 13 . . . cord-028721-x6f26ahr 2708 1 About about RB cord-028721-x6f26ahr 2708 2 10 10 CD cord-028721-x6f26ahr 2708 3 % % NN cord-028721-x6f26ahr 2708 4 of of IN cord-028721-x6f26ahr 2708 5 46XX 46xx CD cord-028721-x6f26ahr 2708 6 males male NNS cord-028721-x6f26ahr 2708 7 are be VBP cord-028721-x6f26ahr 2708 8 SRY sry UH cord-028721-x6f26ahr 2708 9 negative negative JJ cord-028721-x6f26ahr 2708 10 and and CC cord-028721-x6f26ahr 2708 11 most most JJS cord-028721-x6f26ahr 2708 12 have have VBP cord-028721-x6f26ahr 2708 13 ambiguous ambiguous JJ cord-028721-x6f26ahr 2708 14 genitalia genitalia NNS cord-028721-x6f26ahr 2708 15 . . . cord-028721-x6f26ahr 2709 1 Some some DT cord-028721-x6f26ahr 2709 2 patients patient NNS cord-028721-x6f26ahr 2709 3 have have VBP cord-028721-x6f26ahr 2709 4 a a DT cord-028721-x6f26ahr 2709 5 normal normal JJ cord-028721-x6f26ahr 2709 6 male male JJ cord-028721-x6f26ahr 2709 7 phenotype phenotype NN cord-028721-x6f26ahr 2709 8 1161 1161 CD cord-028721-x6f26ahr 2709 9 and and CC cord-028721-x6f26ahr 2709 10 only only RB cord-028721-x6f26ahr 2709 11 infertility infertility NN cord-028721-x6f26ahr 2709 12 . . . cord-028721-x6f26ahr 2710 1 1162 1162 CD cord-028721-x6f26ahr 2711 1 Although although IN cord-028721-x6f26ahr 2711 2 SRY SRY NNP cord-028721-x6f26ahr 2711 3 is be VBZ cord-028721-x6f26ahr 2711 4 assumed assume VBN cord-028721-x6f26ahr 2711 5 to to TO cord-028721-x6f26ahr 2711 6 be be VB cord-028721-x6f26ahr 2711 7 the the DT cord-028721-x6f26ahr 2711 8 most most RBS cord-028721-x6f26ahr 2711 9 important important JJ cord-028721-x6f26ahr 2711 10 regulator regulator NN cord-028721-x6f26ahr 2711 11 factor factor NN cord-028721-x6f26ahr 2711 12 of of IN cord-028721-x6f26ahr 2711 13 testicular testicular JJ cord-028721-x6f26ahr 2711 14 determination determination NN cord-028721-x6f26ahr 2711 15 , , , cord-028721-x6f26ahr 2711 16 these these DT cord-028721-x6f26ahr 2711 17 patients patient NNS cord-028721-x6f26ahr 2711 18 may may MD cord-028721-x6f26ahr 2711 19 have have VB cord-028721-x6f26ahr 2711 20 mutation mutation NN cord-028721-x6f26ahr 2711 21 of of IN cord-028721-x6f26ahr 2711 22 one one CD cord-028721-x6f26ahr 2711 23 of of IN cord-028721-x6f26ahr 2711 24 the the DT cord-028721-x6f26ahr 2711 25 downstream downstream JJ cord-028721-x6f26ahr 2711 26 non non JJ cord-028721-x6f26ahr 2711 27 - - JJ cord-028721-x6f26ahr 2711 28 Y y JJ cord-028721-x6f26ahr 2711 29 testis testis NN cord-028721-x6f26ahr 2711 30 - - HYPH cord-028721-x6f26ahr 2711 31 determining determine VBG cord-028721-x6f26ahr 2711 32 genes gene NNS cord-028721-x6f26ahr 2711 33 . . . cord-028721-x6f26ahr 2712 1 [ [ -LRB- cord-028721-x6f26ahr 2712 2 1163 1163 CD cord-028721-x6f26ahr 2712 3 ] ] -RRB- cord-028721-x6f26ahr 2712 4 [ [ -LRB- cord-028721-x6f26ahr 2712 5 1164 1164 CD cord-028721-x6f26ahr 2712 6 ] ] -RRB- cord-028721-x6f26ahr 2712 7 [ [ -LRB- cord-028721-x6f26ahr 2712 8 1165 1165 CD cord-028721-x6f26ahr 2712 9 ] ] -RRB- cord-028721-x6f26ahr 2712 10 [ [ -LRB- cord-028721-x6f26ahr 2712 11 1166 1166 CD cord-028721-x6f26ahr 2712 12 ] ] -RRB- cord-028721-x6f26ahr 2712 13 About about IN cord-028721-x6f26ahr 2712 14 10 10 CD cord-028721-x6f26ahr 2712 15 % % NN cord-028721-x6f26ahr 2712 16 of of IN cord-028721-x6f26ahr 2712 17 46XX 46xx CD cord-028721-x6f26ahr 2712 18 males male NNS cord-028721-x6f26ahr 2713 1 have have VB cord-028721-x6f26ahr 2713 2 XX XX NNP cord-028721-x6f26ahr 2713 3 / / SYM cord-028721-x6f26ahr 2713 4 XY XY NNP cord-028721-x6f26ahr 2713 5 mosaicism mosaicism NN cord-028721-x6f26ahr 2713 6 or or CC cord-028721-x6f26ahr 2713 7 other other JJ cord-028721-x6f26ahr 2713 8 karyotype karyotype NN cord-028721-x6f26ahr 2713 9 with with IN cord-028721-x6f26ahr 2713 10 the the DT cord-028721-x6f26ahr 2713 11 chromosomal chromosomal JJ cord-028721-x6f26ahr 2713 12 complement complement NN cord-028721-x6f26ahr 2713 13 Y. y. NN cord-028721-x6f26ahr 2714 1 In in IN cord-028721-x6f26ahr 2714 2 these these DT cord-028721-x6f26ahr 2714 3 cases case NNS cord-028721-x6f26ahr 2714 4 , , , cord-028721-x6f26ahr 2714 5 detection detection NN cord-028721-x6f26ahr 2714 6 of of IN cord-028721-x6f26ahr 2714 7 the the DT cord-028721-x6f26ahr 2714 8 specifi specifi NNP cord-028721-x6f26ahr 2714 9 c c NN cord-028721-x6f26ahr 2714 10 DNA dna NN cord-028721-x6f26ahr 2714 11 sequences sequence NNS cord-028721-x6f26ahr 2714 12 of of IN cord-028721-x6f26ahr 2714 13 Y Y NNP cord-028721-x6f26ahr 2714 14 chromosome chromosome NN cord-028721-x6f26ahr 2714 15 may may MD cord-028721-x6f26ahr 2714 16 be be VB cord-028721-x6f26ahr 2714 17 diffi diffi NNP cord-028721-x6f26ahr 2714 18 cult cult NN cord-028721-x6f26ahr 2714 19 because because IN cord-028721-x6f26ahr 2714 20 this this DT cord-028721-x6f26ahr 2714 21 chromosome chromosome NN cord-028721-x6f26ahr 2714 22 may may MD cord-028721-x6f26ahr 2714 23 be be VB cord-028721-x6f26ahr 2714 24 only only RB cord-028721-x6f26ahr 2714 25 in in IN cord-028721-x6f26ahr 2714 26 some some DT cord-028721-x6f26ahr 2714 27 tissues tissue NNS cord-028721-x6f26ahr 2714 28 and and CC cord-028721-x6f26ahr 2714 29 in in IN cord-028721-x6f26ahr 2714 30 a a DT cord-028721-x6f26ahr 2714 31 small small JJ cord-028721-x6f26ahr 2714 32 number number NN cord-028721-x6f26ahr 2714 33 of of IN cord-028721-x6f26ahr 2714 34 cells cell NNS cord-028721-x6f26ahr 2714 35 . . . cord-028721-x6f26ahr 2715 1 1160 1160 CD cord-028721-x6f26ahr 2715 2 47XYY 47xyy CD cord-028721-x6f26ahr 2715 3 syndrome syndrome NN cord-028721-x6f26ahr 2716 1 The the DT cord-028721-x6f26ahr 2716 2 47XYY 47xyy CD cord-028721-x6f26ahr 2716 3 syndrome syndrome NN cord-028721-x6f26ahr 2716 4 was be VBD cord-028721-x6f26ahr 2716 5 fi fi NNP cord-028721-x6f26ahr 2716 6 rst rst NNP cord-028721-x6f26ahr 2716 7 described describe VBN cord-028721-x6f26ahr 2716 8 in in IN cord-028721-x6f26ahr 2716 9 1961 1961 CD cord-028721-x6f26ahr 2716 10 in in IN cord-028721-x6f26ahr 2716 11 the the DT cord-028721-x6f26ahr 2716 12 father father NN cord-028721-x6f26ahr 2716 13 of of IN cord-028721-x6f26ahr 2716 14 a a DT cord-028721-x6f26ahr 2716 15 girl girl NN cord-028721-x6f26ahr 2716 16 with with IN cord-028721-x6f26ahr 2716 17 Down Down NNP cord-028721-x6f26ahr 2716 18 's 's POS cord-028721-x6f26ahr 2716 19 syndrome syndrome NN cord-028721-x6f26ahr 2716 20 . . . cord-028721-x6f26ahr 2717 1 1167 1167 CD cord-028721-x6f26ahr 2718 1 The the DT cord-028721-x6f26ahr 2718 2 only only JJ cord-028721-x6f26ahr 2718 3 clinical clinical JJ cord-028721-x6f26ahr 2718 4 fi fi NN cord-028721-x6f26ahr 2718 5 ndings nding NNS cord-028721-x6f26ahr 2718 6 were be VBD cord-028721-x6f26ahr 2718 7 excessive excessive JJ cord-028721-x6f26ahr 2718 8 height height NN cord-028721-x6f26ahr 2718 9 and and CC cord-028721-x6f26ahr 2718 10 pustular pustular JJ cord-028721-x6f26ahr 2718 11 acne acne NN cord-028721-x6f26ahr 2718 12 . . . cord-028721-x6f26ahr 2719 1 Study study NN cord-028721-x6f26ahr 2719 2 of of IN cord-028721-x6f26ahr 2719 3 other other JJ cord-028721-x6f26ahr 2719 4 cases case NNS cord-028721-x6f26ahr 2719 5 suggests suggest VBZ cord-028721-x6f26ahr 2719 6 that that IN cord-028721-x6f26ahr 2719 7 these these DT cord-028721-x6f26ahr 2719 8 men man NNS cord-028721-x6f26ahr 2719 9 are be VBP cord-028721-x6f26ahr 2719 10 predisposed predisposed JJ cord-028721-x6f26ahr 2719 11 to to IN cord-028721-x6f26ahr 2719 12 a a DT cord-028721-x6f26ahr 2719 13 psychopathic psychopathic JJ cord-028721-x6f26ahr 2719 14 personality personality NN cord-028721-x6f26ahr 2719 15 and and CC cord-028721-x6f26ahr 2719 16 antisocial antisocial JJ cord-028721-x6f26ahr 2719 17 behavior behavior NN cord-028721-x6f26ahr 2719 18 , , , cord-028721-x6f26ahr 2719 19 although although IN cord-028721-x6f26ahr 2719 20 most most JJS cord-028721-x6f26ahr 2719 21 have have VBP cord-028721-x6f26ahr 2719 22 a a DT cord-028721-x6f26ahr 2719 23 normal normal JJ cord-028721-x6f26ahr 2719 24 personality personality NN cord-028721-x6f26ahr 2719 25 and and CC cord-028721-x6f26ahr 2719 26 are be VBP cord-028721-x6f26ahr 2719 27 socially socially RB cord-028721-x6f26ahr 2719 28 adapted adapt VBN cord-028721-x6f26ahr 2719 29 . . . cord-028721-x6f26ahr 2720 1 The the DT cord-028721-x6f26ahr 2720 2 incidence incidence NN cord-028721-x6f26ahr 2720 3 of of IN cord-028721-x6f26ahr 2720 4 47XYY 47xyy CD cord-028721-x6f26ahr 2720 5 patients patient NNS cord-028721-x6f26ahr 2720 6 is be VBZ cord-028721-x6f26ahr 2720 7 estimated estimate VBN cord-028721-x6f26ahr 2720 8 to to TO cord-028721-x6f26ahr 2720 9 be be VB cord-028721-x6f26ahr 2720 10 0.01 0.01 CD cord-028721-x6f26ahr 2720 11 % % NN cord-028721-x6f26ahr 2720 12 of of IN cord-028721-x6f26ahr 2720 13 the the DT cord-028721-x6f26ahr 2720 14 general general JJ cord-028721-x6f26ahr 2720 15 population population NN cord-028721-x6f26ahr 2720 16 , , , cord-028721-x6f26ahr 2720 17 0.7 0.7 CD cord-028721-x6f26ahr 2720 18 - - SYM cord-028721-x6f26ahr 2720 19 0.9 0.9 CD cord-028721-x6f26ahr 2720 20 % % NN cord-028721-x6f26ahr 2720 21 of of IN cord-028721-x6f26ahr 2720 22 men man NNS cord-028721-x6f26ahr 2720 23 in in IN cord-028721-x6f26ahr 2720 24 prison prison NN cord-028721-x6f26ahr 2720 25 , , , cord-028721-x6f26ahr 2720 26 and and CC cord-028721-x6f26ahr 2720 27 1.8 1.8 CD cord-028721-x6f26ahr 2720 28 % % NN cord-028721-x6f26ahr 2720 29 of of IN cord-028721-x6f26ahr 2720 30 sexual sexual JJ cord-028721-x6f26ahr 2720 31 homicide homicide NN cord-028721-x6f26ahr 2720 32 criminals criminal NNS cord-028721-x6f26ahr 2720 33 . . . cord-028721-x6f26ahr 2721 1 1168 1168 CD cord-028721-x6f26ahr 2722 1 The the DT cord-028721-x6f26ahr 2722 2 extra extra JJ cord-028721-x6f26ahr 2722 3 Y Y NNP cord-028721-x6f26ahr 2722 4 chromosome chromosome NN cord-028721-x6f26ahr 2722 5 originates originate VBZ cord-028721-x6f26ahr 2722 6 from from IN cord-028721-x6f26ahr 2722 7 non non JJ cord-028721-x6f26ahr 2722 8 - - JJ cord-028721-x6f26ahr 2722 9 disjunction disjunction NN cord-028721-x6f26ahr 2722 10 during during IN cord-028721-x6f26ahr 2722 11 the the DT cord-028721-x6f26ahr 2722 12 paternal paternal JJ cord-028721-x6f26ahr 2722 13 second second JJ cord-028721-x6f26ahr 2722 14 meiotic meiotic JJ cord-028721-x6f26ahr 2722 15 division division NN cord-028721-x6f26ahr 2722 16 . . . cord-028721-x6f26ahr 2723 1 In in IN cord-028721-x6f26ahr 2723 2 the the DT cord-028721-x6f26ahr 2723 3 past past JJ cord-028721-x6f26ahr 2723 4 decade decade NN cord-028721-x6f26ahr 2723 5 , , , cord-028721-x6f26ahr 2723 6 many many JJ cord-028721-x6f26ahr 2723 7 cases case NNS cord-028721-x6f26ahr 2723 8 have have VBP cord-028721-x6f26ahr 2723 9 been be VBN cord-028721-x6f26ahr 2723 10 diagnosed diagnose VBN cord-028721-x6f26ahr 2723 11 prenatally prenatally RB cord-028721-x6f26ahr 2723 12 . . . cord-028721-x6f26ahr 2724 1 From from IN cord-028721-x6f26ahr 2724 2 birth birth NN cord-028721-x6f26ahr 2724 3 , , , cord-028721-x6f26ahr 2724 4 the the DT cord-028721-x6f26ahr 2724 5 patients patient NNS cord-028721-x6f26ahr 2724 6 have have VBP cord-028721-x6f26ahr 2724 7 weight weight NN cord-028721-x6f26ahr 2724 8 , , , cord-028721-x6f26ahr 2724 9 stature stature NN cord-028721-x6f26ahr 2724 10 and and CC cord-028721-x6f26ahr 2724 11 cephalic cephalic JJ cord-028721-x6f26ahr 2724 12 circumference circumference NN cord-028721-x6f26ahr 2724 13 above above IN cord-028721-x6f26ahr 2724 14 mean mean JJ cord-028721-x6f26ahr 2724 15 values value NNS cord-028721-x6f26ahr 2724 16 and and CC cord-028721-x6f26ahr 2724 17 a a DT cord-028721-x6f26ahr 2724 18 higher high JJR cord-028721-x6f26ahr 2724 19 risk risk NN cord-028721-x6f26ahr 2724 20 for for IN cord-028721-x6f26ahr 2724 21 delayed delay VBN cord-028721-x6f26ahr 2724 22 language language NN cord-028721-x6f26ahr 2724 23 and/or and/or CC cord-028721-x6f26ahr 2724 24 motor motor NN cord-028721-x6f26ahr 2724 25 development development NN cord-028721-x6f26ahr 2724 26 . . . cord-028721-x6f26ahr 2725 1 About about RB cord-028721-x6f26ahr 2725 2 50 50 CD cord-028721-x6f26ahr 2725 3 % % NN cord-028721-x6f26ahr 2725 4 of of IN cord-028721-x6f26ahr 2725 5 children child NNS cord-028721-x6f26ahr 2725 6 have have VBP cord-028721-x6f26ahr 2725 7 psychological psychological JJ cord-028721-x6f26ahr 2725 8 and and CC cord-028721-x6f26ahr 2725 9 psychiatric psychiatric JJ cord-028721-x6f26ahr 2725 10 problems problem NNS cord-028721-x6f26ahr 2725 11 such such JJ cord-028721-x6f26ahr 2725 12 as as IN cord-028721-x6f26ahr 2725 13 autism autism NN cord-028721-x6f26ahr 2725 14 ; ; : cord-028721-x6f26ahr 2725 15 although although IN cord-028721-x6f26ahr 2725 16 their -PRON- PRP$ cord-028721-x6f26ahr 2725 17 intelligence intelligence NN cord-028721-x6f26ahr 2725 18 is be VBZ cord-028721-x6f26ahr 2725 19 normal normal JJ cord-028721-x6f26ahr 2725 20 , , , cord-028721-x6f26ahr 2725 21 many many JJ cord-028721-x6f26ahr 2725 22 patients patient NNS cord-028721-x6f26ahr 2725 23 are be VBP cord-028721-x6f26ahr 2725 24 referred refer VBN cord-028721-x6f26ahr 2725 25 to to IN cord-028721-x6f26ahr 2725 26 special special JJ cord-028721-x6f26ahr 2725 27 education education NN cord-028721-x6f26ahr 2725 28 programs program NNS cord-028721-x6f26ahr 2725 29 . . . cord-028721-x6f26ahr 2726 1 1169 1169 CD cord-028721-x6f26ahr 2727 1 As as IN cord-028721-x6f26ahr 2727 2 adults adult NNS cord-028721-x6f26ahr 2727 3 , , , cord-028721-x6f26ahr 2727 4 they -PRON- PRP cord-028721-x6f26ahr 2727 5 have have VBP cord-028721-x6f26ahr 2727 6 normal normal JJ cord-028721-x6f26ahr 2727 7 external external JJ cord-028721-x6f26ahr 2727 8 genitalia genitalia NNS cord-028721-x6f26ahr 2727 9 and and CC cord-028721-x6f26ahr 2727 10 secondary secondary JJ cord-028721-x6f26ahr 2727 11 sex sex NN cord-028721-x6f26ahr 2727 12 characteristics characteristic NNS cord-028721-x6f26ahr 2727 13 . . . cord-028721-x6f26ahr 2728 1 Fertility fertility NN cord-028721-x6f26ahr 2728 2 is be VBZ cord-028721-x6f26ahr 2728 3 reduced reduce VBN cord-028721-x6f26ahr 2728 4 , , , cord-028721-x6f26ahr 2728 5 1170 1170 CD cord-028721-x6f26ahr 2728 6 although although IN cord-028721-x6f26ahr 2728 7 many many JJ cord-028721-x6f26ahr 2728 8 have have VBP cord-028721-x6f26ahr 2728 9 been be VBN cord-028721-x6f26ahr 2728 10 fathers father NNS cord-028721-x6f26ahr 2728 11 . . . cord-028721-x6f26ahr 2729 1 Usually usually RB cord-028721-x6f26ahr 2729 2 , , , cord-028721-x6f26ahr 2729 3 testicular testicular JJ cord-028721-x6f26ahr 2729 4 biopsy biopsy NN cord-028721-x6f26ahr 2729 5 reveals reveal VBZ cord-028721-x6f26ahr 2729 6 mixed mixed JJ cord-028721-x6f26ahr 2729 7 atrophy atrophy NN cord-028721-x6f26ahr 2729 8 characterized characterize VBN cord-028721-x6f26ahr 2729 9 by by IN cord-028721-x6f26ahr 2729 10 tubules tubule NNS cord-028721-x6f26ahr 2729 11 with with IN cord-028721-x6f26ahr 2729 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2729 13 associated associate VBN cord-028721-x6f26ahr 2729 14 with with IN cord-028721-x6f26ahr 2729 15 Sertoli sertoli JJ cord-028721-x6f26ahr 2729 16 cell cell NN cord-028721-x6f26ahr 2729 17 - - HYPH cord-028721-x6f26ahr 2729 18 only only JJ cord-028721-x6f26ahr 2729 19 tubules tubule NNS cord-028721-x6f26ahr 2729 20 ( ( -LRB- cord-028721-x6f26ahr 2729 21 Fig Fig NNP cord-028721-x6f26ahr 2729 22 . . . cord-028721-x6f26ahr 2729 23 12 12 CD cord-028721-x6f26ahr 2729 24 - - SYM cord-028721-x6f26ahr 2729 25 132 132 CD cord-028721-x6f26ahr 2729 26 ) ) -RRB- cord-028721-x6f26ahr 2729 27 . . . cord-028721-x6f26ahr 2730 1 1171 1171 CD cord-028721-x6f26ahr 2730 2 , , , cord-028721-x6f26ahr 2730 3 1172 1172 CD cord-028721-x6f26ahr 2731 1 Those those DT cord-028721-x6f26ahr 2731 2 tubules tubule NNS cord-028721-x6f26ahr 2731 3 with with IN cord-028721-x6f26ahr 2731 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2731 5 may may MD cord-028721-x6f26ahr 2731 6 show show VB cord-028721-x6f26ahr 2731 7 normal normal JJ cord-028721-x6f26ahr 2731 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2731 9 or or CC cord-028721-x6f26ahr 2731 10 have have VBP cord-028721-x6f26ahr 2731 11 lesions lesion NNS cord-028721-x6f26ahr 2731 12 in in IN cord-028721-x6f26ahr 2731 13 the the DT cord-028721-x6f26ahr 2731 14 adluminal adluminal JJ cord-028721-x6f26ahr 2731 15 or or CC cord-028721-x6f26ahr 2731 16 basal basal NN cord-028721-x6f26ahr 2731 17 compartments compartment NNS cord-028721-x6f26ahr 2731 18 . . . cord-028721-x6f26ahr 2732 1 In in IN cord-028721-x6f26ahr 2732 2 these these DT cord-028721-x6f26ahr 2732 3 tubules tubule NNS cord-028721-x6f26ahr 2732 4 , , , cord-028721-x6f26ahr 2732 5 many many JJ cord-028721-x6f26ahr 2732 6 XXY XXY NNP cord-028721-x6f26ahr 2732 7 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 2732 8 degenerate degenerate VBP cord-028721-x6f26ahr 2732 9 during during IN cord-028721-x6f26ahr 2732 10 meiosis meiosis NN cord-028721-x6f26ahr 2732 11 . . . cord-028721-x6f26ahr 2733 1 About about RB cord-028721-x6f26ahr 2733 2 64 64 CD cord-028721-x6f26ahr 2733 3 % % NN cord-028721-x6f26ahr 2733 4 of of IN cord-028721-x6f26ahr 2733 5 pachytene pachytene NN cord-028721-x6f26ahr 2733 6 cells cell NNS cord-028721-x6f26ahr 2733 7 have have VBP cord-028721-x6f26ahr 2733 8 three three CD cord-028721-x6f26ahr 2733 9 sex sex NN cord-028721-x6f26ahr 2733 10 chromosomes chromosome NNS cord-028721-x6f26ahr 2733 11 . . . cord-028721-x6f26ahr 2734 1 1173 1173 CD cord-028721-x6f26ahr 2735 1 The the DT cord-028721-x6f26ahr 2735 2 number number NN cord-028721-x6f26ahr 2735 3 of of IN cord-028721-x6f26ahr 2735 4 normal normal JJ cord-028721-x6f26ahr 2735 5 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2735 6 in in IN cord-028721-x6f26ahr 2735 7 the the DT cord-028721-x6f26ahr 2735 8 ejaculate ejaculate NN cord-028721-x6f26ahr 2735 9 is be VBZ cord-028721-x6f26ahr 2735 10 low low JJ cord-028721-x6f26ahr 2735 11 . . . cord-028721-x6f26ahr 2736 1 There there EX cord-028721-x6f26ahr 2736 2 is be VBZ cord-028721-x6f26ahr 2736 3 a a DT cord-028721-x6f26ahr 2736 4 high high JJ cord-028721-x6f26ahr 2736 5 incidence incidence NN cord-028721-x6f26ahr 2736 6 of of IN cord-028721-x6f26ahr 2736 7 both both DT cord-028721-x6f26ahr 2736 8 YY YY NNP cord-028721-x6f26ahr 2736 9 and and CC cord-028721-x6f26ahr 2736 10 XY XY NNP cord-028721-x6f26ahr 2736 11 spermatozoa spermatozoa NN cord-028721-x6f26ahr 2736 12 and and CC cord-028721-x6f26ahr 2736 13 disomy disomy NN cord-028721-x6f26ahr 2736 14 18 18 CD cord-028721-x6f26ahr 2736 15 . . . cord-028721-x6f26ahr 2737 1 The the DT cord-028721-x6f26ahr 2737 2 variability variability NN cord-028721-x6f26ahr 2737 3 in in IN cord-028721-x6f26ahr 2737 4 germ germ NN cord-028721-x6f26ahr 2737 5 cell cell NN cord-028721-x6f26ahr 2737 6 development development NN cord-028721-x6f26ahr 2737 7 is be VBZ cord-028721-x6f26ahr 2737 8 apparently apparently RB cord-028721-x6f26ahr 2737 9 due due JJ cord-028721-x6f26ahr 2737 10 to to IN cord-028721-x6f26ahr 2737 11 elimination elimination NN cord-028721-x6f26ahr 2737 12 of of IN cord-028721-x6f26ahr 2737 13 germ germ NN cord-028721-x6f26ahr 2737 14 cells cell NNS cord-028721-x6f26ahr 2737 15 that that WDT cord-028721-x6f26ahr 2737 16 could could MD cord-028721-x6f26ahr 2737 17 not not RB cord-028721-x6f26ahr 2737 18 pair pair VB cord-028721-x6f26ahr 2737 19 their -PRON- PRP$ cord-028721-x6f26ahr 2737 20 sex sex NN cord-028721-x6f26ahr 2737 21 chromosomes chromosome NNS cord-028721-x6f26ahr 2737 22 during during IN cord-028721-x6f26ahr 2737 23 the the DT cord-028721-x6f26ahr 2737 24 fi fi NN cord-028721-x6f26ahr 2737 25 rst rst NN cord-028721-x6f26ahr 2737 26 or or CC cord-028721-x6f26ahr 2737 27 second second JJ cord-028721-x6f26ahr 2737 28 meiotic meiotic JJ cord-028721-x6f26ahr 2737 29 divisions division NNS cord-028721-x6f26ahr 2737 30 1174 1174 CD cord-028721-x6f26ahr 2737 31 or or CC cord-028721-x6f26ahr 2737 32 , , , cord-028721-x6f26ahr 2737 33 later later RB cord-028721-x6f26ahr 2737 34 , , , cord-028721-x6f26ahr 2737 35 during during IN cord-028721-x6f26ahr 2737 36 the the DT cord-028721-x6f26ahr 2737 37 round round JJ cord-028721-x6f26ahr 2737 38 spermatid spermatid JJ cord-028721-x6f26ahr 2737 39 stage stage NN cord-028721-x6f26ahr 2737 40 . . . cord-028721-x6f26ahr 2738 1 1175 1175 CD cord-028721-x6f26ahr 2738 2 Spermatocytes Spermatocytes NNPS cord-028721-x6f26ahr 2738 3 that that WDT cord-028721-x6f26ahr 2738 4 succeed succeed VBP cord-028721-x6f26ahr 2738 5 in in IN cord-028721-x6f26ahr 2738 6 forming form VBG cord-028721-x6f26ahr 2738 7 trivalent trivalent JJ cord-028721-x6f26ahr 2738 8 chromosomes chromosome NNS cord-028721-x6f26ahr 2738 9 are be VBP cord-028721-x6f26ahr 2738 10 initially initially RB cord-028721-x6f26ahr 2738 11 viable viable JJ cord-028721-x6f26ahr 2738 12 . . . cord-028721-x6f26ahr 2739 1 1176 1176 CD cord-028721-x6f26ahr 2740 1 The the DT cord-028721-x6f26ahr 2740 2 ultimate ultimate JJ cord-028721-x6f26ahr 2740 3 trivalent trivalent JJ cord-028721-x6f26ahr 2740 4 chromosome chromosome NN cord-028721-x6f26ahr 2740 5 segregation segregation NN cord-028721-x6f26ahr 2740 6 yields yield VBZ cord-028721-x6f26ahr 2740 7 aneuploid aneuploid JJ cord-028721-x6f26ahr 2740 8 and and CC cord-028721-x6f26ahr 2740 9 euploid euploid NNP cord-028721-x6f26ahr 2740 10 cells cell NNS cord-028721-x6f26ahr 2740 11 in in IN cord-028721-x6f26ahr 2740 12 equal equal JJ cord-028721-x6f26ahr 2740 13 numbers number NNS cord-028721-x6f26ahr 2740 14 . . . cord-028721-x6f26ahr 2741 1 Sertoli sertoli JJ cord-028721-x6f26ahr 2741 2 cell cell NN cord-028721-x6f26ahr 2741 3 - - HYPH cord-028721-x6f26ahr 2741 4 only only JJ cord-028721-x6f26ahr 2741 5 tubules tubule NNS cord-028721-x6f26ahr 2741 6 are be VBP cord-028721-x6f26ahr 2741 7 attributed attribute VBN cord-028721-x6f26ahr 2741 8 to to IN cord-028721-x6f26ahr 2741 9 either either DT cord-028721-x6f26ahr 2741 10 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2741 11 damage damage NN cord-028721-x6f26ahr 2741 12 by by IN cord-028721-x6f26ahr 2741 13 substances substance NNS cord-028721-x6f26ahr 2741 14 released release VBN cord-028721-x6f26ahr 2741 15 from from IN cord-028721-x6f26ahr 2741 16 degenerated degenerate VBN cord-028721-x6f26ahr 2741 17 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 2741 18 1177 1177 CD cord-028721-x6f26ahr 2741 19 or or CC cord-028721-x6f26ahr 2741 20 absence absence NN cord-028721-x6f26ahr 2741 21 of of IN cord-028721-x6f26ahr 2741 22 testicular testicular JJ cord-028721-x6f26ahr 2741 23 colonization colonization NN cord-028721-x6f26ahr 2741 24 by by IN cord-028721-x6f26ahr 2741 25 primordial primordial JJ cord-028721-x6f26ahr 2741 26 germ germ NN cord-028721-x6f26ahr 2741 27 cells cell NNS cord-028721-x6f26ahr 2741 28 . . . cord-028721-x6f26ahr 2742 1 These these DT cord-028721-x6f26ahr 2742 2 men man NNS cord-028721-x6f26ahr 2742 3 have have VBP cord-028721-x6f26ahr 2742 4 normal normal JJ cord-028721-x6f26ahr 2742 5 serum serum NN cord-028721-x6f26ahr 2742 6 levels level NNS cord-028721-x6f26ahr 2742 7 of of IN cord-028721-x6f26ahr 2742 8 testosterone testosterone NN cord-028721-x6f26ahr 2742 9 and and CC cord-028721-x6f26ahr 2742 10 LH lh NN cord-028721-x6f26ahr 2742 11 . . . cord-028721-x6f26ahr 2743 1 The the DT cord-028721-x6f26ahr 2743 2 latter latter JJ cord-028721-x6f26ahr 2743 3 may may MD cord-028721-x6f26ahr 2743 4 be be VB cord-028721-x6f26ahr 2743 5 slightly slightly RB cord-028721-x6f26ahr 2743 6 increased increase VBN cord-028721-x6f26ahr 2743 7 in in IN cord-028721-x6f26ahr 2743 8 47XYY 47xyy CD cord-028721-x6f26ahr 2743 9 men man NNS cord-028721-x6f26ahr 2743 10 with with IN cord-028721-x6f26ahr 2743 11 severe severe JJ cord-028721-x6f26ahr 2743 12 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 2743 13 alterations alteration NNS cord-028721-x6f26ahr 2743 14 . . . cord-028721-x6f26ahr 2744 1 1178 1178 CD cord-028721-x6f26ahr 2745 1 47XYY 47xyy CD cord-028721-x6f26ahr 2745 2 men man NNS cord-028721-x6f26ahr 2745 3 with with IN cord-028721-x6f26ahr 2745 4 mosaicism mosaicism NN cord-028721-x6f26ahr 2745 5 ( ( -LRB- cord-028721-x6f26ahr 2745 6 47XYY/46XY 47xyy/46xy CD cord-028721-x6f26ahr 2745 7 ) ) -RRB- cord-028721-x6f26ahr 2745 8 have have VB cord-028721-x6f26ahr 2745 9 a a DT cord-028721-x6f26ahr 2745 10 higher high JJR cord-028721-x6f26ahr 2745 11 risk risk NN cord-028721-x6f26ahr 2745 12 of of IN cord-028721-x6f26ahr 2745 13 fathering father VBG cord-028721-x6f26ahr 2745 14 children child NNS cord-028721-x6f26ahr 2745 15 with with IN cord-028721-x6f26ahr 2745 16 hyperdiploid hyperdiploid NNP cord-028721-x6f26ahr 2745 17 chromosomal chromosomal JJ cord-028721-x6f26ahr 2745 18 constitution constitution NN cord-028721-x6f26ahr 2745 19 , , , cord-028721-x6f26ahr 2745 20 and and CC cord-028721-x6f26ahr 2745 21 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2745 22 should should MD cord-028721-x6f26ahr 2745 23 be be VB cord-028721-x6f26ahr 2745 24 studied study VBN cord-028721-x6f26ahr 2745 25 genetically genetically RB cord-028721-x6f26ahr 2745 26 to to TO cord-028721-x6f26ahr 2745 27 evaluate evaluate VB cord-028721-x6f26ahr 2745 28 the the DT cord-028721-x6f26ahr 2745 29 risk risk NN cord-028721-x6f26ahr 2745 30 of of IN cord-028721-x6f26ahr 2745 31 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 2745 32 sperm sperm NN cord-028721-x6f26ahr 2745 33 injection injection NN cord-028721-x6f26ahr 2745 34 . . . cord-028721-x6f26ahr 2746 1 1179 1179 CD cord-028721-x6f26ahr 2746 2 Men Men NNPS cord-028721-x6f26ahr 2746 3 with with IN cord-028721-x6f26ahr 2746 4 three three CD cord-028721-x6f26ahr 2746 5 and and CC cord-028721-x6f26ahr 2746 6 four four CD cord-028721-x6f26ahr 2746 7 Y Y NNP cord-028721-x6f26ahr 2746 8 chromosomes chromosome NNS cord-028721-x6f26ahr 2746 9 have have VBP cord-028721-x6f26ahr 2746 10 been be VBN cord-028721-x6f26ahr 2746 11 reported report VBN cord-028721-x6f26ahr 2746 12 . . . cord-028721-x6f26ahr 2747 1 Men man NNS cord-028721-x6f26ahr 2747 2 with with IN cord-028721-x6f26ahr 2747 3 the the DT cord-028721-x6f26ahr 2747 4 48XYYY 48xyyy CD cord-028721-x6f26ahr 2747 5 karyotype karyotype NN cord-028721-x6f26ahr 2747 6 are be VBP cord-028721-x6f26ahr 2747 7 tall tall JJ cord-028721-x6f26ahr 2747 8 and and CC cord-028721-x6f26ahr 2747 9 have have VBP cord-028721-x6f26ahr 2747 10 normal normal JJ cord-028721-x6f26ahr 2747 11 male male JJ cord-028721-x6f26ahr 2747 12 phenotype phenotype NN cord-028721-x6f26ahr 2747 13 , , , cord-028721-x6f26ahr 2747 14 slight slight JJ cord-028721-x6f26ahr 2747 15 mental mental JJ cord-028721-x6f26ahr 2747 16 retardation retardation NN cord-028721-x6f26ahr 2747 17 , , , cord-028721-x6f26ahr 2747 18 azoospermia azoospermia NN cord-028721-x6f26ahr 2747 19 and and CC cord-028721-x6f26ahr 2747 20 , , , cord-028721-x6f26ahr 2747 21 during during IN cord-028721-x6f26ahr 2747 22 childhood childhood NN cord-028721-x6f26ahr 2747 23 , , , cord-028721-x6f26ahr 2747 24 frequent frequent JJ cord-028721-x6f26ahr 2747 25 infections infection NNS cord-028721-x6f26ahr 2747 26 of of IN cord-028721-x6f26ahr 2747 27 the the DT cord-028721-x6f26ahr 2747 28 upper upper JJ cord-028721-x6f26ahr 2747 29 respiratory respiratory JJ cord-028721-x6f26ahr 2747 30 tract tract NN cord-028721-x6f26ahr 2747 31 . . . cord-028721-x6f26ahr 2748 1 1180 1180 CD cord-028721-x6f26ahr 2749 1 Testicular testicular JJ cord-028721-x6f26ahr 2749 2 biopsy biopsy NN cord-028721-x6f26ahr 2749 3 shows show VBZ cord-028721-x6f26ahr 2749 4 Sertoli sertoli JJ cord-028721-x6f26ahr 2749 5 cell cell NN cord-028721-x6f26ahr 2749 6 - - HYPH cord-028721-x6f26ahr 2749 7 only only RB cord-028721-x6f26ahr 2749 8 tubules tubule NNS cord-028721-x6f26ahr 2749 9 , , , cord-028721-x6f26ahr 2749 10 severe severe JJ cord-028721-x6f26ahr 2749 11 hyalinization hyalinization NN cord-028721-x6f26ahr 2749 12 of of IN cord-028721-x6f26ahr 2749 13 tubular tubular JJ cord-028721-x6f26ahr 2749 14 basement basement NN cord-028721-x6f26ahr 2749 15 membrane membrane NN cord-028721-x6f26ahr 2749 16 , , , cord-028721-x6f26ahr 2749 17 and and CC cord-028721-x6f26ahr 2749 18 diffuse diffuse VB cord-028721-x6f26ahr 2749 19 Leydig Leydig NNP cord-028721-x6f26ahr 2749 20 cell cell NN cord-028721-x6f26ahr 2749 21 hyperplasia hyperplasia NN cord-028721-x6f26ahr 2749 22 . . . cord-028721-x6f26ahr 2750 1 The the DT cord-028721-x6f26ahr 2750 2 chromosomal chromosomal JJ cord-028721-x6f26ahr 2750 3 complement complement NN cord-028721-x6f26ahr 2750 4 of of IN cord-028721-x6f26ahr 2750 5 parents parent NNS cord-028721-x6f26ahr 2750 6 can can MD cord-028721-x6f26ahr 2750 7 be be VB cord-028721-x6f26ahr 2750 8 normal normal JJ cord-028721-x6f26ahr 2750 9 . . . cord-028721-x6f26ahr 2751 1 1181 1181 CD cord-028721-x6f26ahr 2751 2 Men man NNS cord-028721-x6f26ahr 2751 3 with with IN cord-028721-x6f26ahr 2751 4 49XYYYY 49xyyyy CD cord-028721-x6f26ahr 2751 5 also also RB cord-028721-x6f26ahr 2751 6 have have VBP cord-028721-x6f26ahr 2751 7 no no DT cord-028721-x6f26ahr 2751 8 signifi signifi NN cord-028721-x6f26ahr 2751 9 ca can MD cord-028721-x6f26ahr 2751 10 nt not RB cord-028721-x6f26ahr 2751 11 phenotypic phenotypic VB cord-028721-x6f26ahr 2751 12 abnormalities abnormality NNS cord-028721-x6f26ahr 2751 13 ( ( -LRB- cord-028721-x6f26ahr 2751 14 except except IN cord-028721-x6f26ahr 2751 15 for for IN cord-028721-x6f26ahr 2751 16 cases case NNS cord-028721-x6f26ahr 2751 17 of of IN cord-028721-x6f26ahr 2751 18 chromosomal chromosomal JJ cord-028721-x6f26ahr 2751 19 mosaicism mosaicism NN cord-028721-x6f26ahr 2751 20 ) ) -RRB- cord-028721-x6f26ahr 2751 21 . . . cord-028721-x6f26ahr 2752 1 Slight slight JJ cord-028721-x6f26ahr 2752 2 mental mental JJ cord-028721-x6f26ahr 2752 3 retardation retardation NN cord-028721-x6f26ahr 2752 4 , , , cord-028721-x6f26ahr 2752 5 infertility infertility NN cord-028721-x6f26ahr 2752 6 , , , cord-028721-x6f26ahr 2752 7 and and CC cord-028721-x6f26ahr 2752 8 antisocial antisocial JJ cord-028721-x6f26ahr 2752 9 behavior behavior NN cord-028721-x6f26ahr 2752 10 are be VBP cord-028721-x6f26ahr 2752 11 the the DT cord-028721-x6f26ahr 2752 12 most most JJS cord-028721-x6f26ahr 2752 13 signifi signifi NN cord-028721-x6f26ahr 2752 14 ca can MD cord-028721-x6f26ahr 2752 15 nt not RB cord-028721-x6f26ahr 2752 16 clinical clinical JJ cord-028721-x6f26ahr 2752 17 fi fi NN cord-028721-x6f26ahr 2752 18 ndings nding NNS cord-028721-x6f26ahr 2752 19 . . . cord-028721-x6f26ahr 2753 1 1182 1182 CD cord-028721-x6f26ahr 2754 1 Rarely rarely RB cord-028721-x6f26ahr 2754 2 patients patient NNS cord-028721-x6f26ahr 2754 3 have have VBP cord-028721-x6f26ahr 2754 4 facial facial JJ cord-028721-x6f26ahr 2754 5 dysmorphism dysmorphism NN cord-028721-x6f26ahr 2754 6 and and CC cord-028721-x6f26ahr 2754 7 various various JJ cord-028721-x6f26ahr 2754 8 skeletal skeletal JJ cord-028721-x6f26ahr 2754 9 abnormalities abnormality NNS cord-028721-x6f26ahr 2754 10 . . . cord-028721-x6f26ahr 2755 1 1183 1183 CD cord-028721-x6f26ahr 2755 2 _SP cord-028721-x6f26ahr 2756 1 The the DT cord-028721-x6f26ahr 2756 2 Y Y NNP cord-028721-x6f26ahr 2756 3 chromosome chromosome NN cord-028721-x6f26ahr 2756 4 is be VBZ cord-028721-x6f26ahr 2756 5 essential essential JJ cord-028721-x6f26ahr 2756 6 for for IN cord-028721-x6f26ahr 2756 7 gender gender NN cord-028721-x6f26ahr 2756 8 determination determination NN cord-028721-x6f26ahr 2756 9 and and CC cord-028721-x6f26ahr 2756 10 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2756 11 , , , cord-028721-x6f26ahr 2756 12 and and CC cord-028721-x6f26ahr 2756 13 abnormalities abnormality NNS cord-028721-x6f26ahr 2756 14 often often RB cord-028721-x6f26ahr 2756 15 lead lead VBP cord-028721-x6f26ahr 2756 16 to to IN cord-028721-x6f26ahr 2756 17 infertility infertility NN cord-028721-x6f26ahr 2756 18 . . . cord-028721-x6f26ahr 2757 1 The the DT cord-028721-x6f26ahr 2757 2 relationship relationship NN cord-028721-x6f26ahr 2757 3 between between IN cord-028721-x6f26ahr 2757 4 Y Y NNP cord-028721-x6f26ahr 2757 5 chromosome chromosome NN cord-028721-x6f26ahr 2757 6 abnormalities abnormality NNS cord-028721-x6f26ahr 2757 7 and and CC cord-028721-x6f26ahr 2757 8 infertility infertility NN cord-028721-x6f26ahr 2757 9 is be VBZ cord-028721-x6f26ahr 2757 10 best best RB cord-028721-x6f26ahr 2757 11 understood understand VBN cord-028721-x6f26ahr 2757 12 in in IN cord-028721-x6f26ahr 2757 13 azoospermic azoospermic NNP cord-028721-x6f26ahr 2757 14 men man NNS cord-028721-x6f26ahr 2757 15 with with IN cord-028721-x6f26ahr 2757 16 alterations alteration NNS cord-028721-x6f26ahr 2757 17 in in IN cord-028721-x6f26ahr 2757 18 Yq11 Yq11 NNP cord-028721-x6f26ahr 2757 19 , , , cord-028721-x6f26ahr 2757 20 the the DT cord-028721-x6f26ahr 2757 21 distal distal JJ cord-028721-x6f26ahr 2757 22 region region NN cord-028721-x6f26ahr 2757 23 of of IN cord-028721-x6f26ahr 2757 24 the the DT cord-028721-x6f26ahr 2757 25 euchromatic euchromatic JJ cord-028721-x6f26ahr 2757 26 part part NN cord-028721-x6f26ahr 2757 27 of of IN cord-028721-x6f26ahr 2757 28 the the DT cord-028721-x6f26ahr 2757 29 long long JJ cord-028721-x6f26ahr 2757 30 Y Y NNP cord-028721-x6f26ahr 2757 31 arm arm NN cord-028721-x6f26ahr 2757 32 , , , cord-028721-x6f26ahr 2757 33 the the DT cord-028721-x6f26ahr 2757 34 location location NN cord-028721-x6f26ahr 2757 35 of of IN cord-028721-x6f26ahr 2757 36 a a DT cord-028721-x6f26ahr 2757 37 male male JJ cord-028721-x6f26ahr 2757 38 fertility fertility NN cord-028721-x6f26ahr 2757 39 gene gene NN cord-028721-x6f26ahr 2757 40 complex complex NN cord-028721-x6f26ahr 2757 41 called call VBN cord-028721-x6f26ahr 2757 42 azoospermia azoospermia NN cord-028721-x6f26ahr 2757 43 factor factor NN cord-028721-x6f26ahr 2757 44 . . . cord-028721-x6f26ahr 2758 1 Infertility Infertility NNP cord-028721-x6f26ahr 2758 2 may may MD cord-028721-x6f26ahr 2758 3 result result VB cord-028721-x6f26ahr 2758 4 from from IN cord-028721-x6f26ahr 2758 5 deletion deletion NN cord-028721-x6f26ahr 2758 6 of of IN cord-028721-x6f26ahr 2758 7 any any DT cord-028721-x6f26ahr 2758 8 of of IN cord-028721-x6f26ahr 2758 9 four four CD cord-028721-x6f26ahr 2758 10 subregions subregion NNS cord-028721-x6f26ahr 2758 11 in in IN cord-028721-x6f26ahr 2758 12 which which WDT cord-028721-x6f26ahr 2758 13 the the DT cord-028721-x6f26ahr 2758 14 azoospermia azoospermia NN cord-028721-x6f26ahr 2758 15 factor factor NN cord-028721-x6f26ahr 2758 16 has have VBZ cord-028721-x6f26ahr 2758 17 been be VBN cord-028721-x6f26ahr 2758 18 divided divide VBN cord-028721-x6f26ahr 2758 19 ( ( -LRB- cord-028721-x6f26ahr 2758 20 AZFa AZFa NNS cord-028721-x6f26ahr 2758 21 , , , cord-028721-x6f26ahr 2758 22 AZFb AZFb NNS cord-028721-x6f26ahr 2758 23 , , , cord-028721-x6f26ahr 2758 24 AZFc AZFc NNS cord-028721-x6f26ahr 2758 25 and and CC cord-028721-x6f26ahr 2758 26 AZFd AZFd NNS cord-028721-x6f26ahr 2758 27 ) ) -RRB- cord-028721-x6f26ahr 2758 28 . . . cord-028721-x6f26ahr 2759 1 1184 1184 CD cord-028721-x6f26ahr 2759 2 , , , cord-028721-x6f26ahr 2759 3 1185 1185 CD cord-028721-x6f26ahr 2760 1 The the DT cord-028721-x6f26ahr 2760 2 best well RBS cord-028721-x6f26ahr 2760 3 - - HYPH cord-028721-x6f26ahr 2760 4 known know VBN cord-028721-x6f26ahr 2760 5 Y y NN cord-028721-x6f26ahr 2760 6 chromosome chromosome NN cord-028721-x6f26ahr 2760 7 genes gene NNS cord-028721-x6f26ahr 2760 8 involved involve VBN cord-028721-x6f26ahr 2760 9 in in IN cord-028721-x6f26ahr 2760 10 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2760 11 are be VBP cord-028721-x6f26ahr 2760 12 RBM RBM NNP cord-028721-x6f26ahr 2760 13 . . . cord-028721-x6f26ahr 2761 1 DAZ DAZ NNP cord-028721-x6f26ahr 2761 2 , , , cord-028721-x6f26ahr 2761 3 DFFRY DFFRY NNP cord-028721-x6f26ahr 2761 4 , , , cord-028721-x6f26ahr 2761 5 CDY CDY NNP cord-028721-x6f26ahr 2761 6 , , , cord-028721-x6f26ahr 2761 7 SMCY SMCY NNP cord-028721-x6f26ahr 2761 8 , , , cord-028721-x6f26ahr 2761 9 and and CC cord-028721-x6f26ahr 2761 10 ZFY ZFY NNP cord-028721-x6f26ahr 2761 11 . . . cord-028721-x6f26ahr 2762 1 Six six CD cord-028721-x6f26ahr 2762 2 different different JJ cord-028721-x6f26ahr 2762 3 partial partial JJ cord-028721-x6f26ahr 2762 4 deletions deletion NNS cord-028721-x6f26ahr 2762 5 of of IN cord-028721-x6f26ahr 2762 6 this this DT cord-028721-x6f26ahr 2762 7 region region NN cord-028721-x6f26ahr 2762 8 have have VBP cord-028721-x6f26ahr 2762 9 been be VBN cord-028721-x6f26ahr 2762 10 found find VBN cord-028721-x6f26ahr 2762 11 in in IN cord-028721-x6f26ahr 2762 12 azoospermic azoospermic NNP cord-028721-x6f26ahr 2762 13 patients patient NNS cord-028721-x6f26ahr 2762 14 ( ( -LRB- cord-028721-x6f26ahr 2762 15 Table table NN cord-028721-x6f26ahr 2763 1 12- 12- LS cord-028721-x6f26ahr 2764 1 Monocentric Monocentric NNP cord-028721-x6f26ahr 2764 2 deleted delete VBD cord-028721-x6f26ahr 2765 1 Yq Yq NNP cord-028721-x6f26ahr 2765 2 chromosome chromosome NN cord-028721-x6f26ahr 2765 3 Partial partial JJ cord-028721-x6f26ahr 2765 4 deletion deletion NN cord-028721-x6f26ahr 2765 5 of of IN cord-028721-x6f26ahr 2765 6 the the DT cord-028721-x6f26ahr 2765 7 distal distal JJ cord-028721-x6f26ahr 2765 8 portion portion NN cord-028721-x6f26ahr 2765 9 of of IN cord-028721-x6f26ahr 2765 10 the the DT cord-028721-x6f26ahr 2765 11 Yq11 Yq11 NNP cord-028721-x6f26ahr 2765 12 euchromatic euchromatic NNP cord-028721-x6f26ahr 2765 13 region region NN cord-028721-x6f26ahr 2765 14 is be VBZ cord-028721-x6f26ahr 2765 15 associated associate VBN cord-028721-x6f26ahr 2765 16 with with IN cord-028721-x6f26ahr 2765 17 azoospermia azoospermia NN cord-028721-x6f26ahr 2765 18 owing owe VBG cord-028721-x6f26ahr 2765 19 to to IN cord-028721-x6f26ahr 2765 20 loss loss NN cord-028721-x6f26ahr 2765 21 of of IN cord-028721-x6f26ahr 2765 22 the the DT cord-028721-x6f26ahr 2765 23 azoospermia azoospermia NN cord-028721-x6f26ahr 2765 24 factor factor NN cord-028721-x6f26ahr 2765 25 . . . cord-028721-x6f26ahr 2766 1 These these DT cord-028721-x6f26ahr 2766 2 men man NNS cord-028721-x6f26ahr 2766 3 have have VBP cord-028721-x6f26ahr 2766 4 normal normal JJ cord-028721-x6f26ahr 2766 5 external external JJ cord-028721-x6f26ahr 2766 6 genitalia genitalia NNS cord-028721-x6f26ahr 2766 7 except except IN cord-028721-x6f26ahr 2766 8 for for IN cord-028721-x6f26ahr 2766 9 small small JJ cord-028721-x6f26ahr 2766 10 testes testis NNS cord-028721-x6f26ahr 2766 11 , , , cord-028721-x6f26ahr 2766 12 1187 1187 CD cord-028721-x6f26ahr 2766 13 normal normal JJ cord-028721-x6f26ahr 2766 14 testosterone testosterone NN cord-028721-x6f26ahr 2766 15 and and CC cord-028721-x6f26ahr 2766 16 LH LH NNP cord-028721-x6f26ahr 2766 17 serum serum NN cord-028721-x6f26ahr 2766 18 levels level NNS cord-028721-x6f26ahr 2766 19 , , , cord-028721-x6f26ahr 2766 20 and and CC cord-028721-x6f26ahr 2766 21 increased increase VBD cord-028721-x6f26ahr 2766 22 FSH fsh NN cord-028721-x6f26ahr 2766 23 serum serum NN cord-028721-x6f26ahr 2766 24 level level NN cord-028721-x6f26ahr 2766 25 . . . cord-028721-x6f26ahr 2767 1 The the DT cord-028721-x6f26ahr 2767 2 most most RBS cord-028721-x6f26ahr 2767 3 frequent frequent JJ cord-028721-x6f26ahr 2767 4 histological histological JJ cord-028721-x6f26ahr 2767 5 fi fi NN cord-028721-x6f26ahr 2767 6 nding nding NN cord-028721-x6f26ahr 2767 7 is be VBZ cord-028721-x6f26ahr 2767 8 Sertoli sertoli JJ cord-028721-x6f26ahr 2767 9 cell cell NN cord-028721-x6f26ahr 2767 10 - - HYPH cord-028721-x6f26ahr 2767 11 only only JJ cord-028721-x6f26ahr 2767 12 pattern pattern NN cord-028721-x6f26ahr 2767 13 , , , cord-028721-x6f26ahr 2767 14 although although IN cord-028721-x6f26ahr 2767 15 many many JJ cord-028721-x6f26ahr 2767 16 other other JJ cord-028721-x6f26ahr 2767 17 patterns pattern NNS cord-028721-x6f26ahr 2767 18 have have VBP cord-028721-x6f26ahr 2767 19 been be VBN cord-028721-x6f26ahr 2767 20 reported report VBN cord-028721-x6f26ahr 2767 21 . . . cord-028721-x6f26ahr 2768 1 1188 1188 CD cord-028721-x6f26ahr 2769 1 The the DT cord-028721-x6f26ahr 2769 2 number number NN cord-028721-x6f26ahr 2769 3 of of IN cord-028721-x6f26ahr 2769 4 Leydig Leydig NNP cord-028721-x6f26ahr 2769 5 cells cell NNS cord-028721-x6f26ahr 2769 6 is be VBZ cord-028721-x6f26ahr 2769 7 normal normal JJ cord-028721-x6f26ahr 2769 8 or or CC cord-028721-x6f26ahr 2769 9 increased increase VBN cord-028721-x6f26ahr 2769 10 . . . cord-028721-x6f26ahr 2770 1 These these DT cord-028721-x6f26ahr 2770 2 fi fi NN cord-028721-x6f26ahr 2770 3 ndings nding NNS cord-028721-x6f26ahr 2770 4 suggest suggest VBP cord-028721-x6f26ahr 2770 5 that that IN cord-028721-x6f26ahr 2770 6 the the DT cord-028721-x6f26ahr 2770 7 azoospermia azoospermia NN cord-028721-x6f26ahr 2770 8 factor factor NN cord-028721-x6f26ahr 2770 9 is be VBZ cord-028721-x6f26ahr 2770 10 required require VBN cord-028721-x6f26ahr 2770 11 for for IN cord-028721-x6f26ahr 2770 12 early early JJ cord-028721-x6f26ahr 2770 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2770 14 . . . cord-028721-x6f26ahr 2771 1 1189 1189 CD cord-028721-x6f26ahr 2772 1 If if IN cord-028721-x6f26ahr 2772 2 the the DT cord-028721-x6f26ahr 2772 3 breakpoint breakpoint NN cord-028721-x6f26ahr 2772 4 of of IN cord-028721-x6f26ahr 2772 5 Yq11 Yq11 NNP cord-028721-x6f26ahr 2772 6 is be VBZ cord-028721-x6f26ahr 2772 7 proximal proximal JJ cord-028721-x6f26ahr 2772 8 to to IN cord-028721-x6f26ahr 2772 9 the the DT cord-028721-x6f26ahr 2772 10 centromere centromere NN cord-028721-x6f26ahr 2772 11 , , , cord-028721-x6f26ahr 2772 12 patients patient NNS cord-028721-x6f26ahr 2772 13 are be VBP cord-028721-x6f26ahr 2772 14 short short JJ cord-028721-x6f26ahr 2772 15 because because IN cord-028721-x6f26ahr 2772 16 the the DT cord-028721-x6f26ahr 2772 17 gene gene NN cord-028721-x6f26ahr 2772 18 that that WDT cord-028721-x6f26ahr 2772 19 controls control VBZ cord-028721-x6f26ahr 2772 20 stature stature NN cord-028721-x6f26ahr 2772 21 is be VBZ cord-028721-x6f26ahr 2772 22 close close JJ cord-028721-x6f26ahr 2772 23 to to IN cord-028721-x6f26ahr 2772 24 that that DT cord-028721-x6f26ahr 2772 25 for for IN cord-028721-x6f26ahr 2772 26 the the DT cord-028721-x6f26ahr 2772 27 azoospermia azoospermia NN cord-028721-x6f26ahr 2772 28 factor factor NN cord-028721-x6f26ahr 2772 29 . . . cord-028721-x6f26ahr 2773 1 1190 1190 CD cord-028721-x6f26ahr 2774 1 Dicentric Dicentric NNP cord-028721-x6f26ahr 2774 2 Yq Yq NNP cord-028721-x6f26ahr 2774 3 isochromosomes isochromosome NNS cord-028721-x6f26ahr 2775 1 Sterility sterility NN cord-028721-x6f26ahr 2775 2 is be VBZ cord-028721-x6f26ahr 2775 3 frequent frequent JJ cord-028721-x6f26ahr 2775 4 in in IN cord-028721-x6f26ahr 2775 5 men man NNS cord-028721-x6f26ahr 2775 6 with with IN cord-028721-x6f26ahr 2775 7 dicentric dicentric NNP cord-028721-x6f26ahr 2775 8 Yq Yq NNP cord-028721-x6f26ahr 2775 9 isochromosomes isochromosome NNS cord-028721-x6f26ahr 2775 10 . . . cord-028721-x6f26ahr 2776 1 1191 1191 CD cord-028721-x6f26ahr 2777 1 This this DT cord-028721-x6f26ahr 2777 2 anomaly anomaly NN cord-028721-x6f26ahr 2777 3 is be VBZ cord-028721-x6f26ahr 2777 4 usually usually RB cord-028721-x6f26ahr 2777 5 associated associate VBN cord-028721-x6f26ahr 2777 6 with with IN cord-028721-x6f26ahr 2777 7 a a DT cord-028721-x6f26ahr 2777 8 45X 45x CD cord-028721-x6f26ahr 2777 9 cell cell NN cord-028721-x6f26ahr 2777 10 line line NN cord-028721-x6f26ahr 2777 11 . . . cord-028721-x6f26ahr 2778 1 The the DT cord-028721-x6f26ahr 2778 2 proportion proportion NN cord-028721-x6f26ahr 2778 3 of of IN cord-028721-x6f26ahr 2778 4 this this DT cord-028721-x6f26ahr 2778 5 line line NN cord-028721-x6f26ahr 2778 6 varies vary VBZ cord-028721-x6f26ahr 2778 7 between between IN cord-028721-x6f26ahr 2778 8 patients patient NNS cord-028721-x6f26ahr 2778 9 and and CC cord-028721-x6f26ahr 2778 10 between between IN cord-028721-x6f26ahr 2778 11 cell cell NN cord-028721-x6f26ahr 2778 12 types type NNS cord-028721-x6f26ahr 2778 13 ( ( -LRB- cord-028721-x6f26ahr 2778 14 fi fi IN cord-028721-x6f26ahr 2778 15 broblasts broblasts NNP cord-028721-x6f26ahr 2778 16 or or CC cord-028721-x6f26ahr 2778 17 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 2778 18 ) ) -RRB- cord-028721-x6f26ahr 2778 19 . . . cord-028721-x6f26ahr 2779 1 When when WRB cord-028721-x6f26ahr 2779 2 the the DT cord-028721-x6f26ahr 2779 3 point point NN cord-028721-x6f26ahr 2779 4 of of IN cord-028721-x6f26ahr 2779 5 breakage breakage NN cord-028721-x6f26ahr 2779 6 and and CC cord-028721-x6f26ahr 2779 7 fusion fusion NN cord-028721-x6f26ahr 2779 8 of of IN cord-028721-x6f26ahr 2779 9 the the DT cord-028721-x6f26ahr 2779 10 two two CD cord-028721-x6f26ahr 2779 11 Y Y NNP cord-028721-x6f26ahr 2779 12 chromosomes chromosome NNS cord-028721-x6f26ahr 2779 13 is be VBZ cord-028721-x6f26ahr 2779 14 in in IN cord-028721-x6f26ahr 2779 15 the the DT cord-028721-x6f26ahr 2779 16 distal distal JJ cord-028721-x6f26ahr 2779 17 region region NN cord-028721-x6f26ahr 2779 18 Yq11 Yq11 NNP cord-028721-x6f26ahr 2779 19 , , , cord-028721-x6f26ahr 2779 20 and and CC cord-028721-x6f26ahr 2779 21 the the DT cord-028721-x6f26ahr 2779 22 second second JJ cord-028721-x6f26ahr 2779 23 centromere centromere NN cord-028721-x6f26ahr 2779 24 is be VBZ cord-028721-x6f26ahr 2779 25 inactivated inactivate VBN cord-028721-x6f26ahr 2779 26 , , , cord-028721-x6f26ahr 2779 27 the the DT cord-028721-x6f26ahr 2779 28 Y Y NNP cord-028721-x6f26ahr 2779 29 isochromosome isochromosome NN cord-028721-x6f26ahr 2779 30 is be VBZ cord-028721-x6f26ahr 2779 31 normal normal JJ cord-028721-x6f26ahr 2779 32 in in IN cord-028721-x6f26ahr 2779 33 size size NN cord-028721-x6f26ahr 2779 34 but but CC cord-028721-x6f26ahr 2779 35 does do VBZ cord-028721-x6f26ahr 2779 36 not not RB cord-028721-x6f26ahr 2779 37 stain stain VB cord-028721-x6f26ahr 2779 38 with with IN cord-028721-x6f26ahr 2779 39 quinacrine quinacrine NN cord-028721-x6f26ahr 2779 40 , , , cord-028721-x6f26ahr 2779 41 and and CC cord-028721-x6f26ahr 2779 42 thus thus RB cord-028721-x6f26ahr 2779 43 is be VBZ cord-028721-x6f26ahr 2779 44 called call VBN cord-028721-x6f26ahr 2779 45 non non JJ cord-028721-x6f26ahr 2779 46 - - JJ cord-028721-x6f26ahr 2779 47 fl fl JJ cord-028721-x6f26ahr 2779 48 uorescent uorescent NNP cord-028721-x6f26ahr 2779 49 Y Y NNP cord-028721-x6f26ahr 2779 50 chromosome chromosome NN cord-028721-x6f26ahr 2779 51 ( ( -LRB- cord-028721-x6f26ahr 2779 52 Ynf Ynf NNP cord-028721-x6f26ahr 2779 53 ) ) -RRB- cord-028721-x6f26ahr 2779 54 . . . cord-028721-x6f26ahr 2780 1 As as IN cord-028721-x6f26ahr 2780 2 the the DT cord-028721-x6f26ahr 2780 3 breakpoint breakpoint NN cord-028721-x6f26ahr 2780 4 is be VBZ cord-028721-x6f26ahr 2780 5 in in IN cord-028721-x6f26ahr 2780 6 the the DT cord-028721-x6f26ahr 2780 7 Yq11 Yq11 NNP cord-028721-x6f26ahr 2780 8 region region NN cord-028721-x6f26ahr 2780 9 , , , cord-028721-x6f26ahr 2780 10 the the DT cord-028721-x6f26ahr 2780 11 azoospermia azoospermia NN cord-028721-x6f26ahr 2780 12 factor factor NN cord-028721-x6f26ahr 2780 13 function function NN cord-028721-x6f26ahr 2780 14 is be VBZ cord-028721-x6f26ahr 2780 15 altered alter VBN cord-028721-x6f26ahr 2780 16 . . . cord-028721-x6f26ahr 2781 1 Development development NN cord-028721-x6f26ahr 2781 2 of of IN cord-028721-x6f26ahr 2781 3 external external JJ cord-028721-x6f26ahr 2781 4 genitalia genitalia NNS cord-028721-x6f26ahr 2781 5 varies vary VBZ cord-028721-x6f26ahr 2781 6 from from IN cord-028721-x6f26ahr 2781 7 ambiguous ambiguous JJ cord-028721-x6f26ahr 2781 8 to to IN cord-028721-x6f26ahr 2781 9 normal normal JJ cord-028721-x6f26ahr 2781 10 , , , cord-028721-x6f26ahr 2781 11 and and CC cord-028721-x6f26ahr 2781 12 is be VBZ cord-028721-x6f26ahr 2781 13 probably probably RB cord-028721-x6f26ahr 2781 14 related related JJ cord-028721-x6f26ahr 2781 15 to to IN cord-028721-x6f26ahr 2781 16 the the DT cord-028721-x6f26ahr 2781 17 extent extent NN cord-028721-x6f26ahr 2781 18 of of IN cord-028721-x6f26ahr 2781 19 XO XO NNP cord-028721-x6f26ahr 2781 20 present present JJ cord-028721-x6f26ahr 2781 21 . . . cord-028721-x6f26ahr 2782 1 1192 1192 CD cord-028721-x6f26ahr 2782 2 Testicular testicular JJ cord-028721-x6f26ahr 2782 3 biopsies biopsy NNS cord-028721-x6f26ahr 2782 4 are be VBP cord-028721-x6f26ahr 2782 5 similar similar JJ cord-028721-x6f26ahr 2782 6 to to IN cord-028721-x6f26ahr 2782 7 those those DT cord-028721-x6f26ahr 2782 8 of of IN cord-028721-x6f26ahr 2782 9 men man NNS cord-028721-x6f26ahr 2782 10 with with IN cord-028721-x6f26ahr 2782 11 monocentric monocentric JJ cord-028721-x6f26ahr 2782 12 deleted delete VBN cord-028721-x6f26ahr 2782 13 Yq Yq NNP cord-028721-x6f26ahr 2782 14 chromosomes chromosome NNS cord-028721-x6f26ahr 2782 15 ( ( -LRB- cord-028721-x6f26ahr 2782 16 Fig fig NN cord-028721-x6f26ahr 2782 17 . . . cord-028721-x6f26ahr 2782 18 _SP cord-028721-x6f26ahr 2783 1 12 12 CD cord-028721-x6f26ahr 2783 2 - - SYM cord-028721-x6f26ahr 2783 3 133 133 CD cord-028721-x6f26ahr 2783 4 ) ) -RRB- cord-028721-x6f26ahr 2783 5 . . . cord-028721-x6f26ahr 2784 1 1193 1193 CD cord-028721-x6f26ahr 2784 2 , , , cord-028721-x6f26ahr 2784 3 1194 1194 CD cord-028721-x6f26ahr 2784 4 Ring Ring NNP cord-028721-x6f26ahr 2784 5 Y Y NNP cord-028721-x6f26ahr 2784 6 chromosome chromosome NN cord-028721-x6f26ahr 2784 7 Men Men NNPS cord-028721-x6f26ahr 2784 8 with with IN cord-028721-x6f26ahr 2784 9 ring ring NN cord-028721-x6f26ahr 2784 10 Y Y NNP cord-028721-x6f26ahr 2784 11 chromosomes chromosome NNS cord-028721-x6f26ahr 2784 12 have have VBP cord-028721-x6f26ahr 2784 13 normal normal JJ cord-028721-x6f26ahr 2784 14 male male JJ cord-028721-x6f26ahr 2784 15 phenotype phenotype NN cord-028721-x6f26ahr 2784 16 , , , cord-028721-x6f26ahr 2784 17 azoospermia azoospermia NN cord-028721-x6f26ahr 2784 18 , , , cord-028721-x6f26ahr 2784 19 and and CC cord-028721-x6f26ahr 2784 20 , , , cord-028721-x6f26ahr 2784 21 in in IN cord-028721-x6f26ahr 2784 22 some some DT cord-028721-x6f26ahr 2784 23 cases case NNS cord-028721-x6f26ahr 2784 24 , , , cord-028721-x6f26ahr 2784 25 short short JJ cord-028721-x6f26ahr 2784 26 stature stature NN cord-028721-x6f26ahr 2784 27 . . . cord-028721-x6f26ahr 2785 1 Most Most JJS cord-028721-x6f26ahr 2785 2 have have VBP cord-028721-x6f26ahr 2785 3 mosaic mosaic NN cord-028721-x6f26ahr 2785 4 karyotype karyotype NN cord-028721-x6f26ahr 2785 5 with with IN cord-028721-x6f26ahr 2785 6 a a DT cord-028721-x6f26ahr 2785 7 45X 45x CD cord-028721-x6f26ahr 2785 8 line line NN cord-028721-x6f26ahr 2785 9 . . . cord-028721-x6f26ahr 2786 1 In in IN cord-028721-x6f26ahr 2786 2 some some DT cord-028721-x6f26ahr 2786 3 cases case NNS cord-028721-x6f26ahr 2786 4 , , , cord-028721-x6f26ahr 2786 5 testicular testicular JJ cord-028721-x6f26ahr 2786 6 biopsy biopsy NN cord-028721-x6f26ahr 2786 7 resembles resemble VBZ cord-028721-x6f26ahr 2786 8 that that DT cord-028721-x6f26ahr 2786 9 of of IN cord-028721-x6f26ahr 2786 10 men man NNS cord-028721-x6f26ahr 2786 11 with with IN cord-028721-x6f26ahr 2786 12 monocentric monocentric JJ cord-028721-x6f26ahr 2786 13 deleted delete VBN cord-028721-x6f26ahr 2786 14 Yq Yq NNP cord-028721-x6f26ahr 2786 15 chromosome chromosome NN cord-028721-x6f26ahr 2786 16 , , , cord-028721-x6f26ahr 2786 17 but but CC cord-028721-x6f26ahr 2786 18 in in IN cord-028721-x6f26ahr 2786 19 others other NNS cord-028721-x6f26ahr 2786 20 there there EX cord-028721-x6f26ahr 2786 21 is be VBZ cord-028721-x6f26ahr 2786 22 premeiotic premeiotic JJ cord-028721-x6f26ahr 2786 23 arrest arrest NN cord-028721-x6f26ahr 2786 24 of of IN cord-028721-x6f26ahr 2786 25 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 2786 26 maturation maturation NN cord-028721-x6f26ahr 2786 27 . . . cord-028721-x6f26ahr 2787 1 1195 1195 CD cord-028721-x6f26ahr 2788 1 This this DT cord-028721-x6f26ahr 2788 2 is be VBZ cord-028721-x6f26ahr 2788 3 attributed attribute VBN cord-028721-x6f26ahr 2788 4 to to IN cord-028721-x6f26ahr 2788 5 diffi diffi NNP cord-028721-x6f26ahr 2788 6 culty culty NNP cord-028721-x6f26ahr 2788 7 in in IN cord-028721-x6f26ahr 2788 8 pairing pair VBG cord-028721-x6f26ahr 2788 9 the the DT cord-028721-x6f26ahr 2788 10 X X NNP cord-028721-x6f26ahr 2788 11 and and CC cord-028721-x6f26ahr 2788 12 Y Y NNP cord-028721-x6f26ahr 2788 13 chromosomes chromosome NNS cord-028721-x6f26ahr 2788 14 during during IN cord-028721-x6f26ahr 2788 15 meiosis meiosis NN cord-028721-x6f26ahr 2788 16 . . . cord-028721-x6f26ahr 2789 1 Many many JJ cord-028721-x6f26ahr 2789 2 patients patient NNS cord-028721-x6f26ahr 2789 3 have have VBP cord-028721-x6f26ahr 2789 4 deletion deletion NN cord-028721-x6f26ahr 2789 5 of of IN cord-028721-x6f26ahr 2789 6 some some DT cord-028721-x6f26ahr 2789 7 AZF AZF NNP cord-028721-x6f26ahr 2789 8 regions region NNS cord-028721-x6f26ahr 2789 9 . . . cord-028721-x6f26ahr 2790 1 1196 1196 CD cord-028721-x6f26ahr 2790 2 , , , cord-028721-x6f26ahr 2790 3 1197 1197 CD cord-028721-x6f26ahr 2790 4 Y Y NNP cord-028721-x6f26ahr 2790 5 / / SYM cord-028721-x6f26ahr 2790 6 Y Y NNP cord-028721-x6f26ahr 2790 7 translocation translocation NN cord-028721-x6f26ahr 2790 8 chromosome chromosome NN cord-028721-x6f26ahr 2790 9 Patients patient NNS cord-028721-x6f26ahr 2790 10 with with IN cord-028721-x6f26ahr 2790 11 this this DT cord-028721-x6f26ahr 2790 12 anomaly anomaly NN cord-028721-x6f26ahr 2790 13 have have VBP cord-028721-x6f26ahr 2790 14 small small JJ cord-028721-x6f26ahr 2790 15 soft soft JJ cord-028721-x6f26ahr 2790 16 testes testis NNS cord-028721-x6f26ahr 2790 17 and and CC cord-028721-x6f26ahr 2791 1 primary primary JJ cord-028721-x6f26ahr 2791 2 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2791 3 maturation maturation NN cord-028721-x6f26ahr 2791 4 arrest arrest NN cord-028721-x6f26ahr 2791 5 owing owe VBG cord-028721-x6f26ahr 2791 6 to to IN cord-028721-x6f26ahr 2791 7 defective defective JJ cord-028721-x6f26ahr 2791 8 pairing pairing NN cord-028721-x6f26ahr 2791 9 of of IN cord-028721-x6f26ahr 2791 10 the the DT cord-028721-x6f26ahr 2791 11 X x NN cord-028721-x6f26ahr 2791 12 and and CC cord-028721-x6f26ahr 2791 13 Y Y NNP cord-028721-x6f26ahr 2791 14 chromosomes chromosome NNS cord-028721-x6f26ahr 2791 15 . . . cord-028721-x6f26ahr 2792 1 The the DT cord-028721-x6f26ahr 2792 2 karyotype karyotype NN cord-028721-x6f26ahr 2792 3 may may MD cord-028721-x6f26ahr 2792 4 be be VB cord-028721-x6f26ahr 2792 5 mosaic mosaic JJ cord-028721-x6f26ahr 2792 6 with with IN cord-028721-x6f26ahr 2792 7 a a DT cord-028721-x6f26ahr 2792 8 45X 45x CD cord-028721-x6f26ahr 2792 9 line line NN cord-028721-x6f26ahr 2792 10 . . . cord-028721-x6f26ahr 2793 1 1198 1198 CD cord-028721-x6f26ahr 2793 2 Translocation Translocation NNP cord-028721-x6f26ahr 2793 3 of of IN cord-028721-x6f26ahr 2793 4 Y Y NNP cord-028721-x6f26ahr 2793 5 chromosome chromosome NN cord-028721-x6f26ahr 2793 6 to to IN cord-028721-x6f26ahr 2793 7 X x NN cord-028721-x6f26ahr 2793 8 chromosome chromosome NN cord-028721-x6f26ahr 2794 1 Most most RBS cord-028721-x6f26ahr 2794 2 frequently frequently RB cord-028721-x6f26ahr 2794 3 this this DT cord-028721-x6f26ahr 2794 4 translocation translocation NN cord-028721-x6f26ahr 2794 5 is be VBZ cord-028721-x6f26ahr 2794 6 cytogenetically cytogenetically RB cord-028721-x6f26ahr 2794 7 undetectable undetectable JJ cord-028721-x6f26ahr 2794 8 , , , cord-028721-x6f26ahr 2794 9 and and CC cord-028721-x6f26ahr 2794 10 patients patient NNS cord-028721-x6f26ahr 2794 11 present present JJ cord-028721-x6f26ahr 2794 12 with with IN cord-028721-x6f26ahr 2794 13 infertility infertility NN cord-028721-x6f26ahr 2794 14 and and CC cord-028721-x6f26ahr 2794 15 are be VBP cord-028721-x6f26ahr 2794 16 found find VBN cord-028721-x6f26ahr 2794 17 to to TO cord-028721-x6f26ahr 2794 18 have have VB cord-028721-x6f26ahr 2794 19 46XX 46xx CD cord-028721-x6f26ahr 2794 20 karyotype karyotype NN cord-028721-x6f26ahr 2794 21 . . . cord-028721-x6f26ahr 2795 1 1199 1199 CD cord-028721-x6f26ahr 2796 1 The the DT cord-028721-x6f26ahr 2796 2 phenotype phenotype NN cord-028721-x6f26ahr 2796 3 is be VBZ cord-028721-x6f26ahr 2796 4 similar similar JJ cord-028721-x6f26ahr 2796 5 to to IN cord-028721-x6f26ahr 2796 6 that that DT cord-028721-x6f26ahr 2796 7 of of IN cord-028721-x6f26ahr 2796 8 men man NNS cord-028721-x6f26ahr 2796 9 with with IN cord-028721-x6f26ahr 2796 10 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2796 11 's 's POS cord-028721-x6f26ahr 2796 12 syndrome syndrome NN cord-028721-x6f26ahr 2796 13 except except IN cord-028721-x6f26ahr 2796 14 for for IN cord-028721-x6f26ahr 2796 15 shorter short JJR cord-028721-x6f26ahr 2796 16 stature stature NN cord-028721-x6f26ahr 2796 17 , , , cord-028721-x6f26ahr 2796 18 absence absence NN cord-028721-x6f26ahr 2796 19 of of IN cord-028721-x6f26ahr 2796 20 mental mental JJ cord-028721-x6f26ahr 2796 21 retardation retardation NN cord-028721-x6f26ahr 2796 22 , , , cord-028721-x6f26ahr 2796 23 and and CC cord-028721-x6f26ahr 2796 24 smaller small JJR cord-028721-x6f26ahr 2796 25 teeth tooth NNS cord-028721-x6f26ahr 2796 26 . . . cord-028721-x6f26ahr 2797 1 Testicular testicular JJ cord-028721-x6f26ahr 2797 2 biopsy biopsy NN cord-028721-x6f26ahr 2797 3 shows show VBZ cord-028721-x6f26ahr 2797 4 Sertoli sertoli JJ cord-028721-x6f26ahr 2797 5 cell cell NN cord-028721-x6f26ahr 2797 6 - - HYPH cord-028721-x6f26ahr 2797 7 only only RB cord-028721-x6f26ahr 2797 8 pattern pattern NN cord-028721-x6f26ahr 2797 9 . . . cord-028721-x6f26ahr 2798 1 Men man NNS cord-028721-x6f26ahr 2798 2 with with IN cord-028721-x6f26ahr 2798 3 cytogenetically cytogenetically RB cord-028721-x6f26ahr 2798 4 detectable detectable JJ cord-028721-x6f26ahr 2798 5 translocations translocation NNS cord-028721-x6f26ahr 2798 6 have have VBP cord-028721-x6f26ahr 2798 7 short short JJ cord-028721-x6f26ahr 2798 8 stature stature NN cord-028721-x6f26ahr 2798 9 , , , cord-028721-x6f26ahr 2798 10 small small JJ cord-028721-x6f26ahr 2798 11 testes testis NNS cord-028721-x6f26ahr 2798 12 , , , cord-028721-x6f26ahr 2798 13 tubular tubular JJ cord-028721-x6f26ahr 2798 14 hyalinization hyalinization NN cord-028721-x6f26ahr 2798 15 , , , cord-028721-x6f26ahr 2798 16 and and CC cord-028721-x6f26ahr 2798 17 prominent prominent JJ cord-028721-x6f26ahr 2798 18 clustered clustered JJ cord-028721-x6f26ahr 2798 19 Leydig Leydig NNP cord-028721-x6f26ahr 2798 20 cells cell NNS cord-028721-x6f26ahr 2798 21 similar similar JJ cord-028721-x6f26ahr 2798 22 to to IN cord-028721-x6f26ahr 2798 23 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2798 24 's 's POS cord-028721-x6f26ahr 2798 25 syndrome syndrome NN cord-028721-x6f26ahr 2798 26 . . . cord-028721-x6f26ahr 2798 27 _SP cord-028721-x6f26ahr 2799 1 Autosomal autosomal JJ cord-028721-x6f26ahr 2799 2 translocation translocation NN cord-028721-x6f26ahr 2799 3 of of IN cord-028721-x6f26ahr 2799 4 Y Y NNP cord-028721-x6f26ahr 2799 5 chromosome chromosome NN cord-028721-x6f26ahr 2799 6 Translocation translocation NN cord-028721-x6f26ahr 2799 7 of of IN cord-028721-x6f26ahr 2799 8 the the DT cord-028721-x6f26ahr 2799 9 distal distal JJ cord-028721-x6f26ahr 2799 10 heterochromatic heterochromatic JJ cord-028721-x6f26ahr 2799 11 portion portion NN cord-028721-x6f26ahr 2799 12 of of IN cord-028721-x6f26ahr 2799 13 the the DT cord-028721-x6f26ahr 2799 14 Y Y NNP cord-028721-x6f26ahr 2799 15 chromosome chromosome NN cord-028721-x6f26ahr 2799 16 to to IN cord-028721-x6f26ahr 2799 17 the the DT cord-028721-x6f26ahr 2799 18 short short JJ cord-028721-x6f26ahr 2799 19 arm arm NN cord-028721-x6f26ahr 2799 20 of of IN cord-028721-x6f26ahr 2799 21 an an DT cord-028721-x6f26ahr 2799 22 acrocentric acrocentric JJ cord-028721-x6f26ahr 2799 23 chromosome chromosome NN cord-028721-x6f26ahr 2799 24 occurs occur VBZ cord-028721-x6f26ahr 2799 25 occasionally occasionally RB cord-028721-x6f26ahr 2799 26 . . . cord-028721-x6f26ahr 2800 1 The the DT cord-028721-x6f26ahr 2800 2 most most RBS cord-028721-x6f26ahr 2800 3 frequent frequent JJ cord-028721-x6f26ahr 2800 4 are be VBP cord-028721-x6f26ahr 2800 5 translocations translocation NNS cord-028721-x6f26ahr 2800 6 to to IN cord-028721-x6f26ahr 2800 7 chromosomes chromosome NNS cord-028721-x6f26ahr 2800 8 5 5 CD cord-028721-x6f26ahr 2800 9 , , , cord-028721-x6f26ahr 2800 10 18 18 CD cord-028721-x6f26ahr 2800 11 , , , cord-028721-x6f26ahr 2800 12 13 13 CD cord-028721-x6f26ahr 2800 13 , , , cord-028721-x6f26ahr 2800 14 15 15 CD cord-028721-x6f26ahr 2800 15 , , , cord-028721-x6f26ahr 2800 16 and and CC cord-028721-x6f26ahr 2800 17 22 22 CD cord-028721-x6f26ahr 2800 18 . . . cord-028721-x6f26ahr 2801 1 The the DT cord-028721-x6f26ahr 2801 2 fertility fertility NN cord-028721-x6f26ahr 2801 3 of of IN cord-028721-x6f26ahr 2801 4 these these DT cord-028721-x6f26ahr 2801 5 men man NNS cord-028721-x6f26ahr 2801 6 depends depend VBZ cord-028721-x6f26ahr 2801 7 on on IN cord-028721-x6f26ahr 2801 8 the the DT cord-028721-x6f26ahr 2801 9 point point NN cord-028721-x6f26ahr 2801 10 of of IN cord-028721-x6f26ahr 2801 11 breakage breakage NN cord-028721-x6f26ahr 2801 12 . . . cord-028721-x6f26ahr 2802 1 1200 1200 CD cord-028721-x6f26ahr 2802 2 , , , cord-028721-x6f26ahr 2802 3 1201 1201 CD cord-028721-x6f26ahr 2802 4 If if IN cord-028721-x6f26ahr 2802 5 this this DT cord-028721-x6f26ahr 2802 6 occurs occur VBZ cord-028721-x6f26ahr 2802 7 in in IN cord-028721-x6f26ahr 2802 8 the the DT cord-028721-x6f26ahr 2802 9 Yq12 Yq12 `` cord-028721-x6f26ahr 2802 10 heterochromatic heterochromatic JJ cord-028721-x6f26ahr 2802 11 region region NN cord-028721-x6f26ahr 2802 12 , , , cord-028721-x6f26ahr 2802 13 the the DT cord-028721-x6f26ahr 2802 14 patient patient NN cord-028721-x6f26ahr 2802 15 has have VBZ cord-028721-x6f26ahr 2802 16 a a DT cord-028721-x6f26ahr 2802 17 male male JJ cord-028721-x6f26ahr 2802 18 phenotype phenotype NN cord-028721-x6f26ahr 2802 19 and and CC cord-028721-x6f26ahr 2802 20 is be VBZ cord-028721-x6f26ahr 2802 21 fertile fertile JJ cord-028721-x6f26ahr 2802 22 . . . cord-028721-x6f26ahr 2803 1 If if IN cord-028721-x6f26ahr 2803 2 the the DT cord-028721-x6f26ahr 2803 3 point point NN cord-028721-x6f26ahr 2803 4 of of IN cord-028721-x6f26ahr 2803 5 breakage breakage NN cord-028721-x6f26ahr 2803 6 is be VBZ cord-028721-x6f26ahr 2803 7 in in IN cord-028721-x6f26ahr 2803 8 the the DT cord-028721-x6f26ahr 2803 9 Yq11 Yq11 NNP cord-028721-x6f26ahr 2803 10 region region NN cord-028721-x6f26ahr 2803 11 , , , cord-028721-x6f26ahr 2803 12 the the DT cord-028721-x6f26ahr 2803 13 patient patient NN cord-028721-x6f26ahr 2803 14 is be VBZ cord-028721-x6f26ahr 2803 15 infertile infertile JJ cord-028721-x6f26ahr 2803 16 and and CC cord-028721-x6f26ahr 2803 17 has have VBZ cord-028721-x6f26ahr 2803 18 small small JJ cord-028721-x6f26ahr 2803 19 testes testis NNS cord-028721-x6f26ahr 2803 20 . . . cord-028721-x6f26ahr 2804 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 2804 2 tubules tubule NNS cord-028721-x6f26ahr 2804 3 may may MD cord-028721-x6f26ahr 2804 4 show show VB cord-028721-x6f26ahr 2804 5 only only RB cord-028721-x6f26ahr 2804 6 Sertoli Sertoli NNP cord-028721-x6f26ahr 2804 7 cells cell NNS cord-028721-x6f26ahr 2804 8 , , , cord-028721-x6f26ahr 2804 9 spermatogenetic spermatogenetic NN cord-028721-x6f26ahr 2804 10 arrest arrest NN cord-028721-x6f26ahr 2804 11 in in IN cord-028721-x6f26ahr 2804 12 early early JJ cord-028721-x6f26ahr 2804 13 stages stage NNS cord-028721-x6f26ahr 2804 14 of of IN cord-028721-x6f26ahr 2804 15 meiosis meiosis NN cord-028721-x6f26ahr 2804 16 , , , cord-028721-x6f26ahr 2804 17 or or CC cord-028721-x6f26ahr 2804 18 an an DT cord-028721-x6f26ahr 2804 19 infantile infantile JJ cord-028721-x6f26ahr 2804 20 pattern pattern NN cord-028721-x6f26ahr 2804 21 . . . cord-028721-x6f26ahr 2805 1 1202 1202 CD cord-028721-x6f26ahr 2805 2 , , , cord-028721-x6f26ahr 2805 3 1203 1203 CD cord-028721-x6f26ahr 2805 4 Interstitial interstitial JJ cord-028721-x6f26ahr 2805 5 microdeletion microdeletion NN cord-028721-x6f26ahr 2805 6 in in IN cord-028721-x6f26ahr 2806 1 Yq11 Yq11 NNP cord-028721-x6f26ahr 2806 2 Yq11 Yq11 NNP cord-028721-x6f26ahr 2807 1 microdeletion microdeletion NN cord-028721-x6f26ahr 2807 2 is be VBZ cord-028721-x6f26ahr 2807 3 the the DT cord-028721-x6f26ahr 2807 4 most most RBS cord-028721-x6f26ahr 2807 5 frequent frequent JJ cord-028721-x6f26ahr 2807 6 congenital congenital JJ cord-028721-x6f26ahr 2807 7 cause cause NN cord-028721-x6f26ahr 2807 8 of of IN cord-028721-x6f26ahr 2807 9 infertility infertility NN cord-028721-x6f26ahr 2807 10 . . . cord-028721-x6f26ahr 2808 1 The the DT cord-028721-x6f26ahr 2808 2 frequency frequency NN cord-028721-x6f26ahr 2808 3 of of IN cord-028721-x6f26ahr 2808 4 Y Y NNP cord-028721-x6f26ahr 2808 5 chromosome chromosome NN cord-028721-x6f26ahr 2808 6 microdeletion microdeletion NN cord-028721-x6f26ahr 2808 7 in in IN cord-028721-x6f26ahr 2808 8 infertile infertile JJ cord-028721-x6f26ahr 2808 9 patients patient NNS cord-028721-x6f26ahr 2808 10 varies vary VBZ cord-028721-x6f26ahr 2808 11 widely widely RB cord-028721-x6f26ahr 2808 12 ( ( -LRB- cord-028721-x6f26ahr 2808 13 1 1 CD cord-028721-x6f26ahr 2808 14 - - SYM cord-028721-x6f26ahr 2808 15 35 35 CD cord-028721-x6f26ahr 2808 16 % % NN cord-028721-x6f26ahr 2808 17 ) ) -RRB- cord-028721-x6f26ahr 2808 18 . . . cord-028721-x6f26ahr 2809 1 1204 1204 CD cord-028721-x6f26ahr 2810 1 In in IN cord-028721-x6f26ahr 2810 2 azoospermic azoospermic JJ cord-028721-x6f26ahr 2810 3 men man NNS cord-028721-x6f26ahr 2810 4 , , , cord-028721-x6f26ahr 2810 5 the the DT cord-028721-x6f26ahr 2810 6 frequency frequency NN cord-028721-x6f26ahr 2810 7 is be VBZ cord-028721-x6f26ahr 2810 8 between between IN cord-028721-x6f26ahr 2810 9 18 18 CD cord-028721-x6f26ahr 2810 10 % % NN cord-028721-x6f26ahr 2810 11 1205 1205 CD cord-028721-x6f26ahr 2810 12 and and CC cord-028721-x6f26ahr 2810 13 37 37 CD cord-028721-x6f26ahr 2810 14 % % NN cord-028721-x6f26ahr 2810 15 . . . cord-028721-x6f26ahr 2811 1 1206 1206 CD cord-028721-x6f26ahr 2812 1 In in IN cord-028721-x6f26ahr 2812 2 oligozoospermic oligozoospermic JJ cord-028721-x6f26ahr 2812 3 males male NNS cord-028721-x6f26ahr 2812 4 the the DT cord-028721-x6f26ahr 2812 5 incidence incidence NN cord-028721-x6f26ahr 2812 6 drops drop VBZ cord-028721-x6f26ahr 2812 7 . . . cord-028721-x6f26ahr 2813 1 Most Most JJS cord-028721-x6f26ahr 2813 2 microdeletions microdeletion NNS cord-028721-x6f26ahr 2813 3 are be VBP cord-028721-x6f26ahr 2813 4 in in IN cord-028721-x6f26ahr 2813 5 the the DT cord-028721-x6f26ahr 2813 6 AZFc AZFc NNS cord-028721-x6f26ahr 2813 7 subregion subregion NN cord-028721-x6f26ahr 2813 8 . . . cord-028721-x6f26ahr 2814 1 1207 1207 CD cord-028721-x6f26ahr 2814 2 , , , cord-028721-x6f26ahr 2814 3 1208 1208 CD cord-028721-x6f26ahr 2814 4 Testicular Testicular NNP cord-028721-x6f26ahr 2814 5 biopsy biopsy NN cord-028721-x6f26ahr 2814 6 shows show VBZ cord-028721-x6f26ahr 2814 7 only only RB cord-028721-x6f26ahr 2814 8 Sertoli sertoli JJ cord-028721-x6f26ahr 2814 9 cells cell NNS cord-028721-x6f26ahr 2814 10 , , , cord-028721-x6f26ahr 2814 11 maturation maturation NN cord-028721-x6f26ahr 2814 12 arrest arrest NN cord-028721-x6f26ahr 2814 13 , , , cord-028721-x6f26ahr 2814 14 or or CC cord-028721-x6f26ahr 2814 15 mixed mixed JJ cord-028721-x6f26ahr 2814 16 atrophy atrophy NN cord-028721-x6f26ahr 2814 17 . . . cord-028721-x6f26ahr 2815 1 There there EX cord-028721-x6f26ahr 2815 2 is be VBZ cord-028721-x6f26ahr 2815 3 no no DT cord-028721-x6f26ahr 2815 4 correlation correlation NN cord-028721-x6f26ahr 2815 5 between between IN cord-028721-x6f26ahr 2815 6 site site NN cord-028721-x6f26ahr 2815 7 of of IN cord-028721-x6f26ahr 2815 8 AZF AZF NNP cord-028721-x6f26ahr 2815 9 subregion subregion NN cord-028721-x6f26ahr 2815 10 alteration alteration NN cord-028721-x6f26ahr 2815 11 and and CC cord-028721-x6f26ahr 2815 12 histological histological JJ cord-028721-x6f26ahr 2815 13 pattern pattern NN cord-028721-x6f26ahr 2815 14 . . . cord-028721-x6f26ahr 2816 1 1209 1209 CD cord-028721-x6f26ahr 2817 1 There there EX cord-028721-x6f26ahr 2817 2 is be VBZ cord-028721-x6f26ahr 2817 3 no no DT cord-028721-x6f26ahr 2817 4 exact exact JJ cord-028721-x6f26ahr 2817 5 correlation correlation NN cord-028721-x6f26ahr 2817 6 between between IN cord-028721-x6f26ahr 2817 7 genotype genotype NN cord-028721-x6f26ahr 2817 8 and and CC cord-028721-x6f26ahr 2817 9 phenotype phenotype NN cord-028721-x6f26ahr 2817 10 , , , cord-028721-x6f26ahr 2817 11 1209 1209 CD cord-028721-x6f26ahr 2817 12 but but CC cord-028721-x6f26ahr 2817 13 most most JJS cord-028721-x6f26ahr 2817 14 microdeletions microdeletion NNS cord-028721-x6f26ahr 2817 15 in in IN cord-028721-x6f26ahr 2817 16 AZFa AZFa NNS cord-028721-x6f26ahr 2817 17 are be VBP cord-028721-x6f26ahr 2817 18 associated associate VBN cord-028721-x6f26ahr 2817 19 with with IN cord-028721-x6f26ahr 2817 20 azoospermia azoospermia NN cord-028721-x6f26ahr 2817 21 , , , cord-028721-x6f26ahr 2817 22 most most JJS cord-028721-x6f26ahr 2817 23 microdeletions microdeletion NNS cord-028721-x6f26ahr 2817 24 in in IN cord-028721-x6f26ahr 2817 25 AZFb AZFb NNS cord-028721-x6f26ahr 2817 26 are be VBP cord-028721-x6f26ahr 2817 27 associated associate VBN cord-028721-x6f26ahr 2817 28 with with IN cord-028721-x6f26ahr 2817 29 maturation maturation NN cord-028721-x6f26ahr 2817 30 arrest arrest NN cord-028721-x6f26ahr 2817 31 , , , cord-028721-x6f26ahr 2817 32 and and CC cord-028721-x6f26ahr 2817 33 most most JJS cord-028721-x6f26ahr 2817 34 microdeletions microdeletion NNS cord-028721-x6f26ahr 2817 35 of of IN cord-028721-x6f26ahr 2817 36 AZFc AZFc NNPS cord-028721-x6f26ahr 2817 37 are be VBP cord-028721-x6f26ahr 2817 38 associated associate VBN cord-028721-x6f26ahr 2817 39 with with IN cord-028721-x6f26ahr 2817 40 spermatid spermatid JJ cord-028721-x6f26ahr 2817 41 maturation maturation NN cord-028721-x6f26ahr 2817 42 arrest arrest NN cord-028721-x6f26ahr 2817 43 or or CC cord-028721-x6f26ahr 2817 44 mixed mix VBN cord-028721-x6f26ahr 2817 45 testicular testicular JJ cord-028721-x6f26ahr 2817 46 atrophy atrophy NN cord-028721-x6f26ahr 2817 47 . . . cord-028721-x6f26ahr 2818 1 Partial partial JJ cord-028721-x6f26ahr 2818 2 deletion deletion NN cord-028721-x6f26ahr 2818 3 of of IN cord-028721-x6f26ahr 2818 4 AZFc AZFc NNS cord-028721-x6f26ahr 2818 5 has have VBZ cord-028721-x6f26ahr 2818 6 a a DT cord-028721-x6f26ahr 2818 7 mild mild JJ cord-028721-x6f26ahr 2818 8 effect effect NN cord-028721-x6f26ahr 2818 9 on on IN cord-028721-x6f26ahr 2818 10 fertility fertility NN cord-028721-x6f26ahr 2818 11 . . . cord-028721-x6f26ahr 2819 1 1210 1210 CD cord-028721-x6f26ahr 2819 2 External external JJ cord-028721-x6f26ahr 2819 3 genitalia genitalia NNS cord-028721-x6f26ahr 2819 4 in in IN cord-028721-x6f26ahr 2819 5 46XY 46xy CD cord-028721-x6f26ahr 2819 6 patients patient NNS cord-028721-x6f26ahr 2819 7 with with IN cord-028721-x6f26ahr 2819 8 duplication duplication NN cord-028721-x6f26ahr 2819 9 of of IN cord-028721-x6f26ahr 2819 10 distal distal JJ cord-028721-x6f26ahr 2819 11 Xp Xp NNP cord-028721-x6f26ahr 2819 12 vary vary VBP cord-028721-x6f26ahr 2819 13 from from IN cord-028721-x6f26ahr 2819 14 male male JJ cord-028721-x6f26ahr 2819 15 , , , cord-028721-x6f26ahr 2819 16 ambiguous ambiguous JJ cord-028721-x6f26ahr 2819 17 , , , cord-028721-x6f26ahr 2819 18 to to IN cord-028721-x6f26ahr 2819 19 female female JJ cord-028721-x6f26ahr 2819 20 , , , cord-028721-x6f26ahr 2819 21 and and CC cord-028721-x6f26ahr 2819 22 gonadal gonadal JJ cord-028721-x6f26ahr 2819 23 dysgenesis dysgenesis NN cord-028721-x6f26ahr 2819 24 is be VBZ cord-028721-x6f26ahr 2819 25 frequent frequent JJ cord-028721-x6f26ahr 2819 26 . . . cord-028721-x6f26ahr 2820 1 If if IN cord-028721-x6f26ahr 2820 2 the the DT cord-028721-x6f26ahr 2820 3 patient patient NN cord-028721-x6f26ahr 2820 4 has have VBZ cord-028721-x6f26ahr 2820 5 male male JJ cord-028721-x6f26ahr 2820 6 genitalia genitalia NNS cord-028721-x6f26ahr 2820 7 , , , cord-028721-x6f26ahr 2820 8 these these DT cord-028721-x6f26ahr 2820 9 are be VBP cord-028721-x6f26ahr 2820 10 usually usually RB cord-028721-x6f26ahr 2820 11 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 2820 12 with with IN cord-028721-x6f26ahr 2820 13 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2820 14 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2820 15 and and CC cord-028721-x6f26ahr 2820 16 , , , cord-028721-x6f26ahr 2820 17 frequently frequently RB cord-028721-x6f26ahr 2820 18 , , , cord-028721-x6f26ahr 2820 19 multiple multiple JJ cord-028721-x6f26ahr 2820 20 congenital congenital JJ cord-028721-x6f26ahr 2820 21 anomalies anomaly NNS cord-028721-x6f26ahr 2820 22 and and CC cord-028721-x6f26ahr 2820 23 mental mental JJ cord-028721-x6f26ahr 2820 24 retardation retardation NN cord-028721-x6f26ahr 2820 25 . . . cord-028721-x6f26ahr 2821 1 1211 1211 CD cord-028721-x6f26ahr 2821 2 Males male NNS cord-028721-x6f26ahr 2821 3 with with IN cord-028721-x6f26ahr 2821 4 translocation translocation NN cord-028721-x6f26ahr 2821 5 of of IN cord-028721-x6f26ahr 2821 6 the the DT cord-028721-x6f26ahr 2821 7 X x NN cord-028721-x6f26ahr 2821 8 chromosome chromosome NN cord-028721-x6f26ahr 2821 9 to to IN cord-028721-x6f26ahr 2821 10 an an DT cord-028721-x6f26ahr 2821 11 autosome autosome NN cord-028721-x6f26ahr 2821 12 may may MD cord-028721-x6f26ahr 2821 13 have have VB cord-028721-x6f26ahr 2821 14 disturbed disturb VBN cord-028721-x6f26ahr 2821 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2821 16 with with IN cord-028721-x6f26ahr 2821 17 subfertility subfertility NN cord-028721-x6f26ahr 2821 18 or or CC cord-028721-x6f26ahr 2821 19 infertility infertility NN cord-028721-x6f26ahr 2821 20 . . . cord-028721-x6f26ahr 2822 1 1212,1213 1212,1213 CD cord-028721-x6f26ahr 2823 1 47XXX 47xxx CD cord-028721-x6f26ahr 2823 2 males male NNS cord-028721-x6f26ahr 2823 3 show show VBP cord-028721-x6f26ahr 2823 4 mental mental JJ cord-028721-x6f26ahr 2823 5 retardation retardation NN cord-028721-x6f26ahr 2823 6 , , , cord-028721-x6f26ahr 2823 7 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2823 8 , , , cord-028721-x6f26ahr 2823 9 normal normal JJ cord-028721-x6f26ahr 2823 10 stature stature NN cord-028721-x6f26ahr 2823 11 , , , cord-028721-x6f26ahr 2823 12 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 2823 13 scrotum scrotum NN cord-028721-x6f26ahr 2823 14 , , , cord-028721-x6f26ahr 2823 15 a a DT cord-028721-x6f26ahr 2823 16 well well RB cord-028721-x6f26ahr 2823 17 - - HYPH cord-028721-x6f26ahr 2823 18 confi confi NN cord-028721-x6f26ahr 2823 19 gured gured NNP cord-028721-x6f26ahr 2823 20 but but CC cord-028721-x6f26ahr 2823 21 small small JJ cord-028721-x6f26ahr 2823 22 penis penis NN cord-028721-x6f26ahr 2823 23 , , , cord-028721-x6f26ahr 2823 24 small small JJ cord-028721-x6f26ahr 2823 25 testes testis NNS cord-028721-x6f26ahr 2823 26 , , , cord-028721-x6f26ahr 2823 27 and and CC cord-028721-x6f26ahr 2823 28 poorly poorly RB cord-028721-x6f26ahr 2823 29 developed develop VBN cord-028721-x6f26ahr 2823 30 pubic pubic NN cord-028721-x6f26ahr 2823 31 hair hair NN cord-028721-x6f26ahr 2823 32 . . . cord-028721-x6f26ahr 2824 1 Serum serum NN cord-028721-x6f26ahr 2824 2 testosterone testosterone NN cord-028721-x6f26ahr 2824 3 levels level NNS cord-028721-x6f26ahr 2824 4 are be VBP cord-028721-x6f26ahr 2824 5 very very RB cord-028721-x6f26ahr 2824 6 low low JJ cord-028721-x6f26ahr 2824 7 . . . cord-028721-x6f26ahr 2825 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 2825 2 tubules tubule NNS cord-028721-x6f26ahr 2825 3 appear appear VBP cord-028721-x6f26ahr 2825 4 severely severely RB cord-028721-x6f26ahr 2825 5 hyalinized hyalinize VBN cord-028721-x6f26ahr 2825 6 . . . cord-028721-x6f26ahr 2826 1 47XXX 47xxx CD cord-028721-x6f26ahr 2826 2 males male NNS cord-028721-x6f26ahr 2826 3 result result VBP cord-028721-x6f26ahr 2826 4 from from IN cord-028721-x6f26ahr 2826 5 an an DT cord-028721-x6f26ahr 2826 6 abnormal abnormal JJ cord-028721-x6f26ahr 2826 7 X x NN cord-028721-x6f26ahr 2826 8 - - NN cord-028721-x6f26ahr 2826 9 Y Y NNP cord-028721-x6f26ahr 2826 10 interchange interchange NN cord-028721-x6f26ahr 2826 11 during during IN cord-028721-x6f26ahr 2826 12 paternal paternal JJ cord-028721-x6f26ahr 2826 13 meiosis meiosis NN cord-028721-x6f26ahr 2826 14 and and CC cord-028721-x6f26ahr 2827 1 X X NNS cord-028721-x6f26ahr 2827 2 - - JJ cord-028721-x6f26ahr 2827 3 X x JJ cord-028721-x6f26ahr 2827 4 non non JJ cord-028721-x6f26ahr 2827 5 - - JJ cord-028721-x6f26ahr 2827 6 disjunction disjunction JJ cord-028721-x6f26ahr 2827 7 during during IN cord-028721-x6f26ahr 2827 8 maternal maternal JJ cord-028721-x6f26ahr 2827 9 meiosis meiosis NN cord-028721-x6f26ahr 2827 10 . . . cord-028721-x6f26ahr 2828 1 1214 1214 CD cord-028721-x6f26ahr 2829 1 There there EX cord-028721-x6f26ahr 2829 2 have have VBP cord-028721-x6f26ahr 2829 3 been be VBN cord-028721-x6f26ahr 2829 4 many many JJ cord-028721-x6f26ahr 2829 5 reports report NNS cord-028721-x6f26ahr 2829 6 on on IN cord-028721-x6f26ahr 2829 7 the the DT cord-028721-x6f26ahr 2829 8 relationship relationship NN cord-028721-x6f26ahr 2829 9 between between IN cord-028721-x6f26ahr 2829 10 autosomal autosomal JJ cord-028721-x6f26ahr 2829 11 anomalies anomaly NNS cord-028721-x6f26ahr 2829 12 and and CC cord-028721-x6f26ahr 2829 13 infertility infertility NN cord-028721-x6f26ahr 2829 14 , , , cord-028721-x6f26ahr 2829 15 although although IN cord-028721-x6f26ahr 2829 16 the the DT cord-028721-x6f26ahr 2829 17 causes cause NNS cord-028721-x6f26ahr 2829 18 are be VBP cord-028721-x6f26ahr 2829 19 not not RB cord-028721-x6f26ahr 2829 20 fully fully RB cord-028721-x6f26ahr 2829 21 understood understand VBN cord-028721-x6f26ahr 2829 22 because because IN cord-028721-x6f26ahr 2829 23 the the DT cord-028721-x6f26ahr 2829 24 same same JJ cord-028721-x6f26ahr 2829 25 anomaly anomaly NN cord-028721-x6f26ahr 2829 26 is be VBZ cord-028721-x6f26ahr 2829 27 associated associate VBN cord-028721-x6f26ahr 2829 28 with with IN cord-028721-x6f26ahr 2829 29 infertility infertility NN cord-028721-x6f26ahr 2829 30 in in IN cord-028721-x6f26ahr 2829 31 some some DT cord-028721-x6f26ahr 2829 32 patients patient NNS cord-028721-x6f26ahr 2829 33 but but CC cord-028721-x6f26ahr 2829 34 not not RB cord-028721-x6f26ahr 2829 35 in in IN cord-028721-x6f26ahr 2829 36 others other NNS cord-028721-x6f26ahr 2829 37 . . . cord-028721-x6f26ahr 2830 1 Robertsonian robertsonian JJ cord-028721-x6f26ahr 2830 2 translocations translocation NNS cord-028721-x6f26ahr 2830 3 are be VBP cord-028721-x6f26ahr 2830 4 found find VBN cord-028721-x6f26ahr 2830 5 in in IN cord-028721-x6f26ahr 2830 6 0.7 0.7 CD cord-028721-x6f26ahr 2830 7 % % NN cord-028721-x6f26ahr 2830 8 of of IN cord-028721-x6f26ahr 2830 9 infertile infertile JJ cord-028721-x6f26ahr 2830 10 men man NNS cord-028721-x6f26ahr 2830 11 ( ( -LRB- cord-028721-x6f26ahr 2830 12 8.5 8.5 CD cord-028721-x6f26ahr 2830 13 % % NN cord-028721-x6f26ahr 2830 14 higher high JJR cord-028721-x6f26ahr 2830 15 than than IN cord-028721-x6f26ahr 2830 16 in in IN cord-028721-x6f26ahr 2830 17 the the DT cord-028721-x6f26ahr 2830 18 normal normal JJ cord-028721-x6f26ahr 2830 19 population population NN cord-028721-x6f26ahr 2830 20 ) ) -RRB- cord-028721-x6f26ahr 2830 21 and and CC cord-028721-x6f26ahr 2830 22 are be VBP cord-028721-x6f26ahr 2830 23 more more RBR cord-028721-x6f26ahr 2830 24 frequent frequent JJ cord-028721-x6f26ahr 2830 25 in in IN cord-028721-x6f26ahr 2830 26 oligozoospermic oligozoospermic NN cord-028721-x6f26ahr 2830 27 than than IN cord-028721-x6f26ahr 2830 28 in in IN cord-028721-x6f26ahr 2830 29 azoospermic azoospermic NNP cord-028721-x6f26ahr 2830 30 men man NNS cord-028721-x6f26ahr 2830 31 . . . cord-028721-x6f26ahr 2831 1 The the DT cord-028721-x6f26ahr 2831 2 most most RBS cord-028721-x6f26ahr 2831 3 frequent frequent JJ cord-028721-x6f26ahr 2831 4 translocations translocation NNS cord-028721-x6f26ahr 2831 5 are be VBP cord-028721-x6f26ahr 2831 6 13;14 13;14 CD cord-028721-x6f26ahr 2831 7 and and CC cord-028721-x6f26ahr 2831 8 14;21 14;21 CD cord-028721-x6f26ahr 2831 9 . . . cord-028721-x6f26ahr 2832 1 The the DT cord-028721-x6f26ahr 2832 2 incidence incidence NN cord-028721-x6f26ahr 2832 3 of of IN cord-028721-x6f26ahr 2832 4 reciprocal reciprocal JJ cord-028721-x6f26ahr 2832 5 translocations translocation NNS cord-028721-x6f26ahr 2832 6 in in IN cord-028721-x6f26ahr 2832 7 infertile infertile JJ cord-028721-x6f26ahr 2832 8 patients patient NNS cord-028721-x6f26ahr 2832 9 is be VBZ cord-028721-x6f26ahr 2832 10 0.5 0.5 CD cord-028721-x6f26ahr 2832 11 % % NN cord-028721-x6f26ahr 2832 12 ( ( -LRB- cord-028721-x6f26ahr 2832 13 0.1 0.1 CD cord-028721-x6f26ahr 2832 14 % % NN cord-028721-x6f26ahr 2832 15 in in IN cord-028721-x6f26ahr 2832 16 the the DT cord-028721-x6f26ahr 2832 17 general general JJ cord-028721-x6f26ahr 2832 18 population population NN cord-028721-x6f26ahr 2832 19 ) ) -RRB- cord-028721-x6f26ahr 2832 20 and and CC cord-028721-x6f26ahr 2832 21 increases increase VBZ cord-028721-x6f26ahr 2832 22 to to IN cord-028721-x6f26ahr 2832 23 0.8 0.8 CD cord-028721-x6f26ahr 2832 24 % % NN cord-028721-x6f26ahr 2832 25 in in IN cord-028721-x6f26ahr 2832 26 patients patient NNS cord-028721-x6f26ahr 2832 27 with with IN cord-028721-x6f26ahr 2832 28 azoospermia azoospermia NN cord-028721-x6f26ahr 2832 29 or or CC cord-028721-x6f26ahr 2832 30 severe severe JJ cord-028721-x6f26ahr 2832 31 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2832 32 . . . cord-028721-x6f26ahr 2833 1 1215 1215 CD cord-028721-x6f26ahr 2834 1 The the DT cord-028721-x6f26ahr 2834 2 most most RBS cord-028721-x6f26ahr 2834 3 frequent frequent JJ cord-028721-x6f26ahr 2834 4 in in IN cord-028721-x6f26ahr 2834 5 infertile infertile JJ cord-028721-x6f26ahr 2834 6 men man NNS cord-028721-x6f26ahr 2834 7 are be VBP cord-028721-x6f26ahr 2834 8 11;22 11;22 CD cord-028721-x6f26ahr 2834 9 and and CC cord-028721-x6f26ahr 2834 10 17;21 17;21 CD cord-028721-x6f26ahr 2834 11 . . . cord-028721-x6f26ahr 2835 1 Paracentric paracentric NN cord-028721-x6f26ahr 2835 2 and and CC cord-028721-x6f26ahr 2835 3 pericentric pericentric JJ cord-028721-x6f26ahr 2835 4 inversions inversion NNS cord-028721-x6f26ahr 2835 5 ( ( -LRB- cord-028721-x6f26ahr 2835 6 except except IN cord-028721-x6f26ahr 2835 7 for for IN cord-028721-x6f26ahr 2835 8 the the DT cord-028721-x6f26ahr 2835 9 pericentric pericentric JJ cord-028721-x6f26ahr 2835 10 inversion inversion NN cord-028721-x6f26ahr 2835 11 of of IN cord-028721-x6f26ahr 2835 12 the the DT cord-028721-x6f26ahr 2835 13 heterochromatic heterochromatic JJ cord-028721-x6f26ahr 2835 14 region region NN cord-028721-x6f26ahr 2835 15 in in IN cord-028721-x6f26ahr 2835 16 chromosome chromosome NN cord-028721-x6f26ahr 2835 17 9 9 CD cord-028721-x6f26ahr 2835 18 ) ) -RRB- cord-028721-x6f26ahr 2835 19 are be VBP cord-028721-x6f26ahr 2835 20 eight eight CD cord-028721-x6f26ahr 2835 21 times time NNS cord-028721-x6f26ahr 2835 22 greater great JJR cord-028721-x6f26ahr 2835 23 in in IN cord-028721-x6f26ahr 2835 24 infertile infertile JJ cord-028721-x6f26ahr 2835 25 patients patient NNS cord-028721-x6f26ahr 2835 26 ( ( -LRB- cord-028721-x6f26ahr 2835 27 0.16 0.16 CD cord-028721-x6f26ahr 2835 28 % % NN cord-028721-x6f26ahr 2835 29 ) ) -RRB- cord-028721-x6f26ahr 2835 30 than than IN cord-028721-x6f26ahr 2835 31 in in IN cord-028721-x6f26ahr 2835 32 the the DT cord-028721-x6f26ahr 2835 33 general general JJ cord-028721-x6f26ahr 2835 34 population population NN cord-028721-x6f26ahr 2835 35 . . . cord-028721-x6f26ahr 2836 1 The the DT cord-028721-x6f26ahr 2836 2 highest high JJS cord-028721-x6f26ahr 2836 3 risk risk NN cord-028721-x6f26ahr 2836 4 for for IN cord-028721-x6f26ahr 2836 5 infertility infertility NN cord-028721-x6f26ahr 2836 6 occurs occur VBZ cord-028721-x6f26ahr 2836 7 in in IN cord-028721-x6f26ahr 2836 8 the the DT cord-028721-x6f26ahr 2836 9 pericentric pericentric JJ cord-028721-x6f26ahr 2836 10 inversion inversion NN cord-028721-x6f26ahr 2836 11 of of IN cord-028721-x6f26ahr 2836 12 chromosome chromosome NN cord-028721-x6f26ahr 2836 13 1 1 CD cord-028721-x6f26ahr 2836 14 . . . cord-028721-x6f26ahr 2837 1 1216 1216 CD cord-028721-x6f26ahr 2837 2 , , , cord-028721-x6f26ahr 2837 3 1217 1217 CD cord-028721-x6f26ahr 2838 1 The the DT cord-028721-x6f26ahr 2838 2 most most RBS cord-028721-x6f26ahr 2838 3 common common JJ cord-028721-x6f26ahr 2838 4 testicular testicular JJ cord-028721-x6f26ahr 2838 5 lesions lesion NNS cord-028721-x6f26ahr 2838 6 in in IN cord-028721-x6f26ahr 2838 7 men man NNS cord-028721-x6f26ahr 2838 8 with with IN cord-028721-x6f26ahr 2838 9 autosomal autosomal JJ cord-028721-x6f26ahr 2838 10 anomalies anomaly NNS cord-028721-x6f26ahr 2838 11 are be VBP cord-028721-x6f26ahr 2838 12 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 2838 13 maturation maturation NN cord-028721-x6f26ahr 2838 14 arrest arrest NN cord-028721-x6f26ahr 2838 15 , , , cord-028721-x6f26ahr 2838 16 primary primary JJ cord-028721-x6f26ahr 2838 17 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 2838 18 sloughing sloughing NN cord-028721-x6f26ahr 2838 19 sometimes sometimes RB cord-028721-x6f26ahr 2838 20 associated associate VBN cord-028721-x6f26ahr 2838 21 with with IN cord-028721-x6f26ahr 2838 22 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2838 23 , , , cord-028721-x6f26ahr 2838 24 and and CC cord-028721-x6f26ahr 2838 25 Sertoli sertoli JJ cord-028721-x6f26ahr 2838 26 cell cell NN cord-028721-x6f26ahr 2838 27 - - HYPH cord-028721-x6f26ahr 2838 28 only only RB cord-028721-x6f26ahr 2838 29 pattern pattern NN cord-028721-x6f26ahr 2838 30 . . . cord-028721-x6f26ahr 2839 1 1218 1218 CD cord-028721-x6f26ahr 2840 1 The the DT cord-028721-x6f26ahr 2840 2 only only JJ cord-028721-x6f26ahr 2840 3 autosomal autosomal JJ cord-028721-x6f26ahr 2840 4 anomaly anomaly NN cord-028721-x6f26ahr 2840 5 with with IN cord-028721-x6f26ahr 2840 6 prolonged prolong VBN cord-028721-x6f26ahr 2840 7 survival survival NN cord-028721-x6f26ahr 2840 8 is be VBZ cord-028721-x6f26ahr 2840 9 Down Down NNP cord-028721-x6f26ahr 2840 10 's 's POS cord-028721-x6f26ahr 2840 11 syndrome syndrome NN cord-028721-x6f26ahr 2840 12 . . . cord-028721-x6f26ahr 2841 1 In in IN cord-028721-x6f26ahr 2841 2 addition addition NN cord-028721-x6f26ahr 2841 3 to to IN cord-028721-x6f26ahr 2841 4 trisomy trisomy NN cord-028721-x6f26ahr 2841 5 of of IN cord-028721-x6f26ahr 2841 6 chromosome chromosome NN cord-028721-x6f26ahr 2841 7 21 21 CD cord-028721-x6f26ahr 2841 8 and and CC cord-028721-x6f26ahr 2841 9 the the DT cord-028721-x6f26ahr 2841 10 characteristic characteristic JJ cord-028721-x6f26ahr 2841 11 appearance appearance NN cord-028721-x6f26ahr 2841 12 , , , cord-028721-x6f26ahr 2841 13 patients patient NNS cord-028721-x6f26ahr 2841 14 with with IN cord-028721-x6f26ahr 2841 15 Down Down NNP cord-028721-x6f26ahr 2841 16 's 's POS cord-028721-x6f26ahr 2841 17 syndrome syndrome NN cord-028721-x6f26ahr 2841 18 usually usually RB cord-028721-x6f26ahr 2841 19 have have VBP cord-028721-x6f26ahr 2841 20 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2841 21 , , , cord-028721-x6f26ahr 2841 22 small small JJ cord-028721-x6f26ahr 2841 23 testes testis NNS cord-028721-x6f26ahr 2841 24 , , , cord-028721-x6f26ahr 2841 25 hypoplasia hypoplasia NN cord-028721-x6f26ahr 2841 26 of of IN cord-028721-x6f26ahr 2841 27 the the DT cord-028721-x6f26ahr 2841 28 penis penis NN cord-028721-x6f26ahr 2841 29 and and CC cord-028721-x6f26ahr 2841 30 scrotum scrotum NN cord-028721-x6f26ahr 2841 31 , , , cord-028721-x6f26ahr 2841 32 and and CC cord-028721-x6f26ahr 2841 33 hypospadias hypospadia NNS cord-028721-x6f26ahr 2841 34 . . . cord-028721-x6f26ahr 2842 1 1219 1219 LS cord-028721-x6f26ahr 2842 2 Adults adult NNS cord-028721-x6f26ahr 2842 3 have have VBP cord-028721-x6f26ahr 2842 4 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2842 5 or or CC cord-028721-x6f26ahr 2842 6 azoospermia azoospermia NN cord-028721-x6f26ahr 2842 7 secondary secondary JJ cord-028721-x6f26ahr 2842 8 to to IN cord-028721-x6f26ahr 2842 9 primary primary JJ cord-028721-x6f26ahr 2842 10 testicular testicular NNP cord-028721-x6f26ahr 2842 11 defi defi NNP cord-028721-x6f26ahr 2842 12 ciency ciency NNP cord-028721-x6f26ahr 2842 13 . . . cord-028721-x6f26ahr 2843 1 Levels level NNS cord-028721-x6f26ahr 2843 2 of of IN cord-028721-x6f26ahr 2843 3 FSH fsh NN cord-028721-x6f26ahr 2843 4 and and CC cord-028721-x6f26ahr 2843 5 LH LH NNP cord-028721-x6f26ahr 2843 6 are be VBP cord-028721-x6f26ahr 2843 7 elevated elevate VBN cord-028721-x6f26ahr 2843 8 , , , cord-028721-x6f26ahr 2843 9 but but CC cord-028721-x6f26ahr 2843 10 testosterone testosterone NN cord-028721-x6f26ahr 2843 11 is be VBZ cord-028721-x6f26ahr 2843 12 normal normal JJ cord-028721-x6f26ahr 2843 13 or or CC cord-028721-x6f26ahr 2843 14 slightly slightly RB cord-028721-x6f26ahr 2843 15 diminished diminished JJ cord-028721-x6f26ahr 2843 16 . . . cord-028721-x6f26ahr 2844 1 1220 1220 CD cord-028721-x6f26ahr 2845 1 Isolated isolated JJ cord-028721-x6f26ahr 2845 2 cases case NNS cord-028721-x6f26ahr 2845 3 of of IN cord-028721-x6f26ahr 2845 4 paternity paternity NN cord-028721-x6f26ahr 2845 5 have have VBP cord-028721-x6f26ahr 2845 6 been be VBN cord-028721-x6f26ahr 2845 7 reported report VBN cord-028721-x6f26ahr 2845 8 . . . cord-028721-x6f26ahr 2846 1 1221 1221 CD cord-028721-x6f26ahr 2846 2 , , , cord-028721-x6f26ahr 2846 3 1222 1222 CD cord-028721-x6f26ahr 2847 1 In in IN cord-028721-x6f26ahr 2847 2 utero utero NNS cord-028721-x6f26ahr 2847 3 , , , cord-028721-x6f26ahr 2847 4 there there EX cord-028721-x6f26ahr 2847 5 is be VBZ cord-028721-x6f26ahr 2847 6 marked mark VBN cord-028721-x6f26ahr 2847 7 delay delay NN cord-028721-x6f26ahr 2847 8 in in IN cord-028721-x6f26ahr 2847 9 germ germ NN cord-028721-x6f26ahr 2847 10 cell cell NN cord-028721-x6f26ahr 2847 11 development development NN cord-028721-x6f26ahr 2847 12 . . . cord-028721-x6f26ahr 2848 1 1223 1223 CD cord-028721-x6f26ahr 2849 1 Histologic Histologic NNP cord-028721-x6f26ahr 2849 2 studies study NNS cord-028721-x6f26ahr 2849 3 of of IN cord-028721-x6f26ahr 2849 4 prepubertal prepubertal JJ cord-028721-x6f26ahr 2849 5 testes testis NNS cord-028721-x6f26ahr 2849 6 at at IN cord-028721-x6f26ahr 2849 7 autopsy autopsy JJ cord-028721-x6f26ahr 2849 8 reveal reveal VBP cord-028721-x6f26ahr 2849 9 decreased decrease VBD cord-028721-x6f26ahr 2849 10 tubular tubular JJ cord-028721-x6f26ahr 2849 11 diameter diameter NN cord-028721-x6f26ahr 2849 12 and and CC cord-028721-x6f26ahr 2849 13 tubular tubular JJ cord-028721-x6f26ahr 2849 14 fertility fertility NN cord-028721-x6f26ahr 2849 15 index index NN cord-028721-x6f26ahr 2849 16 . . . cord-028721-x6f26ahr 2850 1 Eosinophilic eosinophilic JJ cord-028721-x6f26ahr 2850 2 bodies body NNS cord-028721-x6f26ahr 2850 3 or or CC cord-028721-x6f26ahr 2850 4 microliths microlith NNS cord-028721-x6f26ahr 2850 5 may may MD cord-028721-x6f26ahr 2850 6 be be VB cord-028721-x6f26ahr 2850 7 present present JJ cord-028721-x6f26ahr 2850 8 in in IN cord-028721-x6f26ahr 2850 9 some some DT cord-028721-x6f26ahr 2850 10 tubules tubule NNS cord-028721-x6f26ahr 2850 11 ( ( -LRB- cord-028721-x6f26ahr 2850 12 Fig Fig NNP cord-028721-x6f26ahr 2850 13 . . . cord-028721-x6f26ahr 2850 14 12 12 CD cord-028721-x6f26ahr 2850 15 - - SYM cord-028721-x6f26ahr 2850 16 134 134 CD cord-028721-x6f26ahr 2850 17 ) ) -RRB- cord-028721-x6f26ahr 2850 18 . . . cord-028721-x6f26ahr 2851 1 Adult adult NN cord-028721-x6f26ahr 2851 2 testes testis NNS cord-028721-x6f26ahr 2851 3 have have VBP cord-028721-x6f26ahr 2851 4 defi defi NNP cord-028721-x6f26ahr 2851 5 cient cient NNP cord-028721-x6f26ahr 2851 6 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2851 7 and and CC cord-028721-x6f26ahr 2851 8 mixed mixed JJ cord-028721-x6f26ahr 2851 9 atrophy atrophy NN cord-028721-x6f26ahr 2851 10 , , , cord-028721-x6f26ahr 2851 11 with with IN cord-028721-x6f26ahr 2851 12 some some DT cord-028721-x6f26ahr 2851 13 tubules tubule NNS cord-028721-x6f26ahr 2851 14 showing show VBG cord-028721-x6f26ahr 2851 15 complete complete JJ cord-028721-x6f26ahr 2851 16 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2851 17 and and CC cord-028721-x6f26ahr 2851 18 others other NNS cord-028721-x6f26ahr 2851 19 containing contain VBG cord-028721-x6f26ahr 2851 20 Sertoli sertoli JJ cord-028721-x6f26ahr 2851 21 cellonly cellonly NN cord-028721-x6f26ahr 2851 22 pattern pattern NN cord-028721-x6f26ahr 2851 23 . . . cord-028721-x6f26ahr 2852 1 1224 1224 CD cord-028721-x6f26ahr 2853 1 Hypergonadotropic Hypergonadotropic NNP cord-028721-x6f26ahr 2853 2 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2853 3 is be VBZ cord-028721-x6f26ahr 2853 4 found find VBN cord-028721-x6f26ahr 2853 5 in in IN cord-028721-x6f26ahr 2853 6 several several JJ cord-028721-x6f26ahr 2853 7 myopathies myopathy NNS cord-028721-x6f26ahr 2853 8 ( ( -LRB- cord-028721-x6f26ahr 2853 9 myotonic myotonic JJ cord-028721-x6f26ahr 2853 10 dystrophy dystrophy NN cord-028721-x6f26ahr 2853 11 and and CC cord-028721-x6f26ahr 2853 12 progressive progressive JJ cord-028721-x6f26ahr 2853 13 muscular muscular JJ cord-028721-x6f26ahr 2853 14 Fig fig NN cord-028721-x6f26ahr 2853 15 . . . cord-028721-x6f26ahr 2854 1 12 12 CD cord-028721-x6f26ahr 2854 2 - - SYM cord-028721-x6f26ahr 2854 3 134 134 CD cord-028721-x6f26ahr 2854 4 Prepubertal Prepubertal NNP cord-028721-x6f26ahr 2854 5 testis testis NN cord-028721-x6f26ahr 2854 6 in in IN cord-028721-x6f26ahr 2854 7 Down Down NNP cord-028721-x6f26ahr 2854 8 's 's POS cord-028721-x6f26ahr 2854 9 syndrome syndrome NN cord-028721-x6f26ahr 2854 10 . . . cord-028721-x6f26ahr 2855 1 There there EX cord-028721-x6f26ahr 2855 2 are be VBP cord-028721-x6f26ahr 2855 3 megatubules megatubule NNS cord-028721-x6f26ahr 2855 4 , , , cord-028721-x6f26ahr 2855 5 ring ring NN cord-028721-x6f26ahr 2855 6 - - HYPH cord-028721-x6f26ahr 2855 7 shaped shape VBN cord-028721-x6f26ahr 2855 8 tubules tubule NNS cord-028721-x6f26ahr 2855 9 , , , cord-028721-x6f26ahr 2855 10 and and CC cord-028721-x6f26ahr 2855 11 small small JJ cord-028721-x6f26ahr 2855 12 tubules tubule NNS cord-028721-x6f26ahr 2855 13 . . . cord-028721-x6f26ahr 2856 1 Germ germ NN cord-028721-x6f26ahr 2856 2 cell cell NN cord-028721-x6f26ahr 2856 3 number number NN cord-028721-x6f26ahr 2856 4 is be VBZ cord-028721-x6f26ahr 2856 5 very very RB cord-028721-x6f26ahr 2856 6 low low JJ cord-028721-x6f26ahr 2856 7 in in IN cord-028721-x6f26ahr 2856 8 all all PDT cord-028721-x6f26ahr 2856 9 these these DT cord-028721-x6f26ahr 2856 10 tubules tubule NNS cord-028721-x6f26ahr 2856 11 . . . cord-028721-x6f26ahr 2857 1 Eosinophilic eosinophilic JJ cord-028721-x6f26ahr 2857 2 bodies body NNS cord-028721-x6f26ahr 2857 3 or or CC cord-028721-x6f26ahr 2857 4 microliths microlith NNS cord-028721-x6f26ahr 2857 5 are be VBP cord-028721-x6f26ahr 2857 6 present present JJ cord-028721-x6f26ahr 2857 7 in in IN cord-028721-x6f26ahr 2857 8 some some DT cord-028721-x6f26ahr 2857 9 tubules tubule NNS cord-028721-x6f26ahr 2857 10 . . . cord-028721-x6f26ahr 2858 1 dystrophy dystrophy NNP cord-028721-x6f26ahr 2858 2 ) ) -RRB- cord-028721-x6f26ahr 2858 3 and and CC cord-028721-x6f26ahr 2858 4 dermopathies dermopathie NNS cord-028721-x6f26ahr 2858 5 ( ( -LRB- cord-028721-x6f26ahr 2858 6 Bloom Bloom NNP cord-028721-x6f26ahr 2858 7 's 's POS cord-028721-x6f26ahr 2858 8 , , , cord-028721-x6f26ahr 2858 9 Rothmund Rothmund NNP cord-028721-x6f26ahr 2858 10 - - HYPH cord-028721-x6f26ahr 2858 11 Thomson Thomson NNP cord-028721-x6f26ahr 2858 12 , , , cord-028721-x6f26ahr 2858 13 Werner Werner NNP cord-028721-x6f26ahr 2858 14 's 's POS cord-028721-x6f26ahr 2858 15 , , , cord-028721-x6f26ahr 2858 16 Cockayne Cockayne NNP cord-028721-x6f26ahr 2858 17 's 's POS cord-028721-x6f26ahr 2858 18 , , , cord-028721-x6f26ahr 2858 19 and and CC cord-028721-x6f26ahr 2858 20 Tay Tay NNP cord-028721-x6f26ahr 2858 21 's 's POS cord-028721-x6f26ahr 2858 22 syndromes syndrome NNS cord-028721-x6f26ahr 2858 23 ) ) -RRB- cord-028721-x6f26ahr 2858 24 , , , cord-028721-x6f26ahr 2858 25 with with IN cord-028721-x6f26ahr 2858 26 testicular testicular JJ cord-028721-x6f26ahr 2858 27 histology histology NN cord-028721-x6f26ahr 2858 28 that that WDT cord-028721-x6f26ahr 2858 29 resembles resemble VBZ cord-028721-x6f26ahr 2858 30 that that DT cord-028721-x6f26ahr 2858 31 of of IN cord-028721-x6f26ahr 2858 32 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 2858 33 's 's POS cord-028721-x6f26ahr 2858 34 syndrome syndrome NN cord-028721-x6f26ahr 2858 35 . . . cord-028721-x6f26ahr 2859 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 2859 2 is be VBZ cord-028721-x6f26ahr 2859 3 also also RB cord-028721-x6f26ahr 2859 4 observed observe VBN cord-028721-x6f26ahr 2859 5 in in IN cord-028721-x6f26ahr 2859 6 Noonan Noonan NNP cord-028721-x6f26ahr 2859 7 's 's POS cord-028721-x6f26ahr 2859 8 syndrome syndrome NN cord-028721-x6f26ahr 2859 9 , , , cord-028721-x6f26ahr 2859 10 cerebellar cerebellar JJ cord-028721-x6f26ahr 2859 11 ataxia ataxia NN cord-028721-x6f26ahr 2859 12 ( ( -LRB- cord-028721-x6f26ahr 2859 13 with with IN cord-028721-x6f26ahr 2859 14 milder mild JJR cord-028721-x6f26ahr 2859 15 testicular testicular JJ cord-028721-x6f26ahr 2859 16 lesions lesion NNS cord-028721-x6f26ahr 2859 17 ) ) -RRB- cord-028721-x6f26ahr 2859 18 , , , cord-028721-x6f26ahr 2859 19 and and CC cord-028721-x6f26ahr 2859 20 a a DT cord-028721-x6f26ahr 2859 21 miscellaneous miscellaneous JJ cord-028721-x6f26ahr 2859 22 group group NN cord-028721-x6f26ahr 2859 23 of of IN cord-028721-x6f26ahr 2859 24 syndromes syndrome NNS cord-028721-x6f26ahr 2859 25 with with IN cord-028721-x6f26ahr 2859 26 variable variable JJ cord-028721-x6f26ahr 2859 27 histological histological JJ cord-028721-x6f26ahr 2859 28 fi fi NN cord-028721-x6f26ahr 2859 29 ndings nding NNS cord-028721-x6f26ahr 2859 30 . . . cord-028721-x6f26ahr 2860 1 1225 1225 CD cord-028721-x6f26ahr 2860 2 Myotonic Myotonic NNP cord-028721-x6f26ahr 2860 3 dystrophy dystrophy NN cord-028721-x6f26ahr 2860 4 accounts account VBZ cord-028721-x6f26ahr 2860 5 for for IN cord-028721-x6f26ahr 2860 6 approximately approximately RB cord-028721-x6f26ahr 2860 7 30 30 CD cord-028721-x6f26ahr 2860 8 % % NN cord-028721-x6f26ahr 2860 9 of of IN cord-028721-x6f26ahr 2860 10 men man NNS cord-028721-x6f26ahr 2860 11 with with IN cord-028721-x6f26ahr 2860 12 muscular muscular JJ cord-028721-x6f26ahr 2860 13 disorders disorder NNS cord-028721-x6f26ahr 2860 14 , , , cord-028721-x6f26ahr 2860 15 and and CC cord-028721-x6f26ahr 2860 16 about about RB cord-028721-x6f26ahr 2860 17 80 80 CD cord-028721-x6f26ahr 2860 18 % % NN cord-028721-x6f26ahr 2860 19 have have VBP cord-028721-x6f26ahr 2860 20 testicular testicular JJ cord-028721-x6f26ahr 2860 21 atrophy atrophy NN cord-028721-x6f26ahr 2860 22 . . . cord-028721-x6f26ahr 2861 1 The the DT cord-028721-x6f26ahr 2861 2 estimated estimate VBN cord-028721-x6f26ahr 2861 3 incidence incidence NN cord-028721-x6f26ahr 2861 4 is be VBZ cord-028721-x6f26ahr 2861 5 1 1 CD cord-028721-x6f26ahr 2861 6 in in IN cord-028721-x6f26ahr 2861 7 8000 8000 CD cord-028721-x6f26ahr 2861 8 live live JJ cord-028721-x6f26ahr 2861 9 births birth NNS cord-028721-x6f26ahr 2861 10 . . . cord-028721-x6f26ahr 2862 1 The the DT cord-028721-x6f26ahr 2862 2 abnormality abnormality NN cord-028721-x6f26ahr 2862 3 involves involve VBZ cord-028721-x6f26ahr 2862 4 the the DT cord-028721-x6f26ahr 2862 5 distal distal JJ cord-028721-x6f26ahr 2862 6 muscles muscle NNS cord-028721-x6f26ahr 2862 7 of of IN cord-028721-x6f26ahr 2862 8 the the DT cord-028721-x6f26ahr 2862 9 extremities extremity NNS cord-028721-x6f26ahr 2862 10 . . . cord-028721-x6f26ahr 2863 1 In in IN cord-028721-x6f26ahr 2863 2 addition addition NN cord-028721-x6f26ahr 2863 3 , , , cord-028721-x6f26ahr 2863 4 patients patient NNS cord-028721-x6f26ahr 2863 5 may may MD cord-028721-x6f26ahr 2863 6 have have VB cord-028721-x6f26ahr 2863 7 premature premature JJ cord-028721-x6f26ahr 2863 8 baldness baldness NN cord-028721-x6f26ahr 2863 9 , , , cord-028721-x6f26ahr 2863 10 posterior posterior NNP cord-028721-x6f26ahr 2863 11 subcapsular subcapsular NNP cord-028721-x6f26ahr 2863 12 cataracts cataract NNS cord-028721-x6f26ahr 2863 13 , , , cord-028721-x6f26ahr 2863 14 cardiac cardiac JJ cord-028721-x6f26ahr 2863 15 conduction conduction NN cord-028721-x6f26ahr 2863 16 defects defect NNS cord-028721-x6f26ahr 2863 17 , , , cord-028721-x6f26ahr 2863 18 impotence impotence NN cord-028721-x6f26ahr 2863 19 , , , cord-028721-x6f26ahr 2863 20 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2863 21 ( ( -LRB- cord-028721-x6f26ahr 2863 22 rarely rarely RB cord-028721-x6f26ahr 2863 23 ) ) -RRB- cord-028721-x6f26ahr 2863 24 , , , cord-028721-x6f26ahr 2863 25 and and CC cord-028721-x6f26ahr 2863 26 dementia dementia NN cord-028721-x6f26ahr 2863 27 ( ( -LRB- cord-028721-x6f26ahr 2863 28 at at IN cord-028721-x6f26ahr 2863 29 later later JJ cord-028721-x6f26ahr 2863 30 stages stage NNS cord-028721-x6f26ahr 2863 31 ) ) -RRB- cord-028721-x6f26ahr 2863 32 . . . cord-028721-x6f26ahr 2864 1 Myotonic myotonic JJ cord-028721-x6f26ahr 2864 2 dystrophy dystrophy NN cord-028721-x6f26ahr 2864 3 is be VBZ cord-028721-x6f26ahr 2864 4 an an DT cord-028721-x6f26ahr 2864 5 autosomal autosomal JJ cord-028721-x6f26ahr 2864 6 dominant dominant JJ cord-028721-x6f26ahr 2864 7 inherited inherit VBN cord-028721-x6f26ahr 2864 8 disease disease NN cord-028721-x6f26ahr 2864 9 with with IN cord-028721-x6f26ahr 2864 10 variable variable JJ cord-028721-x6f26ahr 2864 11 penetrance penetrance NN cord-028721-x6f26ahr 2864 12 . . . cord-028721-x6f26ahr 2865 1 Two two CD cord-028721-x6f26ahr 2865 2 loci locus NNS cord-028721-x6f26ahr 2865 3 are be VBP cord-028721-x6f26ahr 2865 4 associated associate VBN cord-028721-x6f26ahr 2865 5 with with IN cord-028721-x6f26ahr 2865 6 the the DT cord-028721-x6f26ahr 2865 7 disease disease NN cord-028721-x6f26ahr 2865 8 phenotype phenotype NN cord-028721-x6f26ahr 2865 9 : : : cord-028721-x6f26ahr 2865 10 DM1 dm1 NN cord-028721-x6f26ahr 2865 11 in in IN cord-028721-x6f26ahr 2865 12 19q13.3 19q13.3 CD cord-028721-x6f26ahr 2865 13 , , , cord-028721-x6f26ahr 2865 14 and and CC cord-028721-x6f26ahr 2865 15 DM2 DM2 NNP cord-028721-x6f26ahr 2865 16 in in IN cord-028721-x6f26ahr 2865 17 chromosome chromosome NN cord-028721-x6f26ahr 2865 18 3 3 CD cord-028721-x6f26ahr 2865 19 . . . cord-028721-x6f26ahr 2866 1 Mutation mutation NN cord-028721-x6f26ahr 2866 2 in in IN cord-028721-x6f26ahr 2866 3 DM1 dm1 NN cord-028721-x6f26ahr 2866 4 results result VBZ cord-028721-x6f26ahr 2866 5 in in IN cord-028721-x6f26ahr 2866 6 a a DT cord-028721-x6f26ahr 2866 7 serine serine NN cord-028721-x6f26ahr 2866 8 / / SYM cord-028721-x6f26ahr 2866 9 threonine threonine NN cord-028721-x6f26ahr 2866 10 protein protein NN cord-028721-x6f26ahr 2866 11 kinase kinase NN cord-028721-x6f26ahr 2866 12 defi defi NNP cord-028721-x6f26ahr 2866 13 ciency ciency NNP cord-028721-x6f26ahr 2866 14 that that WDT cord-028721-x6f26ahr 2866 15 causes cause VBZ cord-028721-x6f26ahr 2866 16 expansion expansion NN cord-028721-x6f26ahr 2866 17 of of IN cord-028721-x6f26ahr 2866 18 a a DT cord-028721-x6f26ahr 2866 19 CTG CTG NNP cord-028721-x6f26ahr 2866 20 repeat repeat NN cord-028721-x6f26ahr 2866 21 ( ( -LRB- cord-028721-x6f26ahr 2866 22 from from IN cord-028721-x6f26ahr 2866 23 50 50 CD cord-028721-x6f26ahr 2866 24 to to IN cord-028721-x6f26ahr 2866 25 several several JJ cord-028721-x6f26ahr 2866 26 hundred hundred CD cord-028721-x6f26ahr 2866 27 repeats repeat NNS cord-028721-x6f26ahr 2866 28 ) ) -RRB- cord-028721-x6f26ahr 2866 29 located locate VBN cord-028721-x6f26ahr 2866 30 on on IN cord-028721-x6f26ahr 2866 31 the the DT cord-028721-x6f26ahr 2866 32 3′-untranslated 3′-untranslated CD cord-028721-x6f26ahr 2866 33 region region NN cord-028721-x6f26ahr 2866 34 of of IN cord-028721-x6f26ahr 2866 35 the the DT cord-028721-x6f26ahr 2866 36 dystrophy dystrophy NN cord-028721-x6f26ahr 2866 37 myotonic myotonic JJ cord-028721-x6f26ahr 2866 38 - - HYPH cord-028721-x6f26ahr 2866 39 protein protein NN cord-028721-x6f26ahr 2866 40 kinase kinase NN cord-028721-x6f26ahr 2866 41 gene gene NN cord-028721-x6f26ahr 2866 42 . . . cord-028721-x6f26ahr 2867 1 The the DT cord-028721-x6f26ahr 2867 2 number number NN cord-028721-x6f26ahr 2867 3 of of IN cord-028721-x6f26ahr 2867 4 repeats repeat NNS cord-028721-x6f26ahr 2867 5 is be VBZ cord-028721-x6f26ahr 2867 6 positively positively RB cord-028721-x6f26ahr 2867 7 correlated correlate VBN cord-028721-x6f26ahr 2867 8 to to IN cord-028721-x6f26ahr 2867 9 severity severity NN cord-028721-x6f26ahr 2867 10 of of IN cord-028721-x6f26ahr 2867 11 the the DT cord-028721-x6f26ahr 2867 12 disease disease NN cord-028721-x6f26ahr 2867 13 and and CC cord-028721-x6f26ahr 2867 14 negatively negatively RB cord-028721-x6f26ahr 2867 15 correlated correlate VBN cord-028721-x6f26ahr 2867 16 to to IN cord-028721-x6f26ahr 2867 17 age age NN cord-028721-x6f26ahr 2867 18 of of IN cord-028721-x6f26ahr 2867 19 clinical clinical JJ cord-028721-x6f26ahr 2867 20 onset onset NN cord-028721-x6f26ahr 2867 21 . . . cord-028721-x6f26ahr 2868 1 [ [ -LRB- cord-028721-x6f26ahr 2868 2 1226 1226 CD cord-028721-x6f26ahr 2868 3 ] ] -RRB- cord-028721-x6f26ahr 2869 1 [ [ -LRB- cord-028721-x6f26ahr 2869 2 1227 1227 CD cord-028721-x6f26ahr 2869 3 ] ] -RRB- cord-028721-x6f26ahr 2869 4 [ [ -LRB- cord-028721-x6f26ahr 2869 5 1228 1228 CD cord-028721-x6f26ahr 2869 6 ] ] -RRB- cord-028721-x6f26ahr 2870 1 DM2 DM2 NNP cord-028721-x6f26ahr 2870 2 is be VBZ cord-028721-x6f26ahr 2870 3 caused cause VBN cord-028721-x6f26ahr 2870 4 by by IN cord-028721-x6f26ahr 2870 5 a a DT cord-028721-x6f26ahr 2870 6 mutation mutation NN cord-028721-x6f26ahr 2870 7 in in IN cord-028721-x6f26ahr 2870 8 3q21.3 3q21.3 CD cord-028721-x6f26ahr 2870 9 of of IN cord-028721-x6f26ahr 2870 10 the the DT cord-028721-x6f26ahr 2870 11 ZNF9 ZNF9 NNP cord-028721-x6f26ahr 2870 12 gene gene NN cord-028721-x6f26ahr 2870 13 and and CC cord-028721-x6f26ahr 2870 14 accounts account NNS cord-028721-x6f26ahr 2870 15 for for IN cord-028721-x6f26ahr 2870 16 CCTG CCTG NNP cord-028721-x6f26ahr 2870 17 - - HYPH cord-028721-x6f26ahr 2870 18 repeat repeat NN cord-028721-x6f26ahr 2870 19 expansion expansion NN cord-028721-x6f26ahr 2870 20 ( ( -LRB- cord-028721-x6f26ahr 2870 21 from from IN cord-028721-x6f26ahr 2870 22 75 75 CD cord-028721-x6f26ahr 2870 23 to to TO cord-028721-x6f26ahr 2870 24 11 11 CD cord-028721-x6f26ahr 2870 25 000 000 CD cord-028721-x6f26ahr 2870 26 repeats repeat NNS cord-028721-x6f26ahr 2870 27 ) ) -RRB- cord-028721-x6f26ahr 2870 28 in in IN cord-028721-x6f26ahr 2870 29 intron intron NN cord-028721-x6f26ahr 2870 30 1 1 CD cord-028721-x6f26ahr 2870 31 of of IN cord-028721-x6f26ahr 2870 32 this this DT cord-028721-x6f26ahr 2870 33 gene gene NN cord-028721-x6f26ahr 2870 34 . . . cord-028721-x6f26ahr 2871 1 The the DT cord-028721-x6f26ahr 2871 2 common common JJ cord-028721-x6f26ahr 2871 3 clinical clinical JJ cord-028721-x6f26ahr 2871 4 symptoms symptom NNS cord-028721-x6f26ahr 2871 5 are be VBP cord-028721-x6f26ahr 2871 6 due due JJ cord-028721-x6f26ahr 2871 7 to to IN cord-028721-x6f26ahr 2871 8 gain gain NN cord-028721-x6f26ahr 2871 9 of of IN cord-028721-x6f26ahr 2871 10 function function NN cord-028721-x6f26ahr 2871 11 of of IN cord-028721-x6f26ahr 2871 12 RNA RNA NNP cord-028721-x6f26ahr 2871 13 mechanism mechanism NN cord-028721-x6f26ahr 2871 14 in in IN cord-028721-x6f26ahr 2871 15 CUG CUG NNP cord-028721-x6f26ahr 2871 16 and and CC cord-028721-x6f26ahr 2871 17 CCUG CCUG NNP cord-028721-x6f26ahr 2871 18 repeats repeat VBZ cord-028721-x6f26ahr 2871 19 altering alter VBG cord-028721-x6f26ahr 2871 20 cellular cellular JJ cord-028721-x6f26ahr 2871 21 function function NN cord-028721-x6f26ahr 2871 22 , , , cord-028721-x6f26ahr 2871 23 including include VBG cord-028721-x6f26ahr 2871 24 alternative alternative JJ cord-028721-x6f26ahr 2871 25 splicing splicing NN cord-028721-x6f26ahr 2871 26 of of IN cord-028721-x6f26ahr 2871 27 various various JJ cord-028721-x6f26ahr 2871 28 genes gene NNS cord-028721-x6f26ahr 2871 29 . . . cord-028721-x6f26ahr 2872 1 1229 1229 CD cord-028721-x6f26ahr 2873 1 The the DT cord-028721-x6f26ahr 2873 2 severity severity NN cord-028721-x6f26ahr 2873 3 of of IN cord-028721-x6f26ahr 2873 4 the the DT cord-028721-x6f26ahr 2873 5 disease disease NN cord-028721-x6f26ahr 2873 6 increases increase VBZ cord-028721-x6f26ahr 2873 7 in in IN cord-028721-x6f26ahr 2873 8 the the DT cord-028721-x6f26ahr 2873 9 successive successive JJ cord-028721-x6f26ahr 2873 10 generations generation NNS cord-028721-x6f26ahr 2873 11 . . . cord-028721-x6f26ahr 2874 1 1230 1230 CD cord-028721-x6f26ahr 2875 1 The the DT cord-028721-x6f26ahr 2875 2 number number NN cord-028721-x6f26ahr 2875 3 of of IN cord-028721-x6f26ahr 2875 4 CTG CTG NNP cord-028721-x6f26ahr 2875 5 repeats repeat VBZ cord-028721-x6f26ahr 2875 6 is be VBZ cord-028721-x6f26ahr 2875 7 not not RB cord-028721-x6f26ahr 2875 8 associated associate VBN cord-028721-x6f26ahr 2875 9 with with IN cord-028721-x6f26ahr 2875 10 male male JJ cord-028721-x6f26ahr 2875 11 subfertility subfertility NN cord-028721-x6f26ahr 2875 12 . . . cord-028721-x6f26ahr 2876 1 1231 1231 CD cord-028721-x6f26ahr 2876 2 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 2876 3 is be VBZ cord-028721-x6f26ahr 2876 4 hypergonadotropic hypergonadotropic JJ cord-028721-x6f26ahr 2876 5 in in IN cord-028721-x6f26ahr 2876 6 most most JJS cord-028721-x6f26ahr 2876 7 cases case NNS cord-028721-x6f26ahr 2876 8 and and CC cord-028721-x6f26ahr 2876 9 is be VBZ cord-028721-x6f26ahr 2876 10 not not RB cord-028721-x6f26ahr 2876 11 related relate VBN cord-028721-x6f26ahr 2876 12 to to IN cord-028721-x6f26ahr 2876 13 the the DT cord-028721-x6f26ahr 2876 14 number number NN cord-028721-x6f26ahr 2876 15 of of IN cord-028721-x6f26ahr 2876 16 CTG CTG NNP cord-028721-x6f26ahr 2876 17 repeats repeat VBZ cord-028721-x6f26ahr 2876 18 . . . cord-028721-x6f26ahr 2877 1 1232 1232 CD cord-028721-x6f26ahr 2877 2 Testicular testicular JJ cord-028721-x6f26ahr 2877 3 lesions lesion NNS cord-028721-x6f26ahr 2877 4 probably probably RB cord-028721-x6f26ahr 2877 5 begin begin VBP cord-028721-x6f26ahr 2877 6 late late RB cord-028721-x6f26ahr 2877 7 because because IN cord-028721-x6f26ahr 2877 8 65 65 CD cord-028721-x6f26ahr 2877 9 % % NN cord-028721-x6f26ahr 2877 10 of of IN cord-028721-x6f26ahr 2877 11 patients patient NNS cord-028721-x6f26ahr 2877 12 are be VBP cord-028721-x6f26ahr 2877 13 fathers father NNS cord-028721-x6f26ahr 2877 14 . . . cord-028721-x6f26ahr 2878 1 Testicular testicular JJ cord-028721-x6f26ahr 2878 2 biopsy biopsy NN cord-028721-x6f26ahr 2878 3 shows show VBZ cord-028721-x6f26ahr 2878 4 different different JJ cord-028721-x6f26ahr 2878 5 degrees degree NNS cord-028721-x6f26ahr 2878 6 of of IN cord-028721-x6f26ahr 2878 7 severity severity NN cord-028721-x6f26ahr 2878 8 , , , cord-028721-x6f26ahr 2878 9 ranging range VBG cord-028721-x6f26ahr 2878 10 from from IN cord-028721-x6f26ahr 2878 11 nearly nearly RB cord-028721-x6f26ahr 2878 12 normal normal JJ cord-028721-x6f26ahr 2878 13 to to TO cord-028721-x6f26ahr 2878 14 fully fully RB cord-028721-x6f26ahr 2878 15 hyalinized hyalinize VBN cord-028721-x6f26ahr 2878 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 2878 17 tubules tubule NNS cord-028721-x6f26ahr 2878 18 , , , cord-028721-x6f26ahr 2878 19 with with IN cord-028721-x6f26ahr 2878 20 the the DT cord-028721-x6f26ahr 2878 21 number number NN cord-028721-x6f26ahr 2878 22 of of IN cord-028721-x6f26ahr 2878 23 Leydig Leydig NNP cord-028721-x6f26ahr 2878 24 cells cell NNS cord-028721-x6f26ahr 2878 25 varying vary VBG cord-028721-x6f26ahr 2878 26 from from IN cord-028721-x6f26ahr 2878 27 increased increase VBN cord-028721-x6f26ahr 2878 28 to to IN cord-028721-x6f26ahr 2878 29 decreased decrease VBN cord-028721-x6f26ahr 2878 30 . . . cord-028721-x6f26ahr 2879 1 In in IN cord-028721-x6f26ahr 2879 2 some some DT cord-028721-x6f26ahr 2879 3 patients patient NNS cord-028721-x6f26ahr 2879 4 the the DT cord-028721-x6f26ahr 2879 5 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2879 6 is be VBZ cord-028721-x6f26ahr 2879 7 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2879 8 , , , cord-028721-x6f26ahr 2879 9 and and CC cord-028721-x6f26ahr 2879 10 the the DT cord-028721-x6f26ahr 2879 11 testes testis NNS cord-028721-x6f26ahr 2879 12 show show VBP cord-028721-x6f26ahr 2879 13 an an DT cord-028721-x6f26ahr 2879 14 infantile infantile JJ cord-028721-x6f26ahr 2879 15 pattern pattern NN cord-028721-x6f26ahr 2879 16 . . . cord-028721-x6f26ahr 2880 1 Infertility infertility NN cord-028721-x6f26ahr 2880 2 may may MD cord-028721-x6f26ahr 2880 3 be be VB cord-028721-x6f26ahr 2880 4 the the DT cord-028721-x6f26ahr 2880 5 fi fi NN cord-028721-x6f26ahr 2880 6 rst rst NN cord-028721-x6f26ahr 2880 7 symptom symptom NN cord-028721-x6f26ahr 2880 8 of of IN cord-028721-x6f26ahr 2880 9 myotonic myotonic JJ cord-028721-x6f26ahr 2880 10 dystrophy dystrophy NN cord-028721-x6f26ahr 2880 11 . . . cord-028721-x6f26ahr 2881 1 1233 1233 CD cord-028721-x6f26ahr 2881 2 Progressive progressive JJ cord-028721-x6f26ahr 2881 3 muscular muscular JJ cord-028721-x6f26ahr 2881 4 dystrophy dystrophy NN cord-028721-x6f26ahr 2881 5 is be VBZ cord-028721-x6f26ahr 2881 6 a a DT cord-028721-x6f26ahr 2881 7 multisystemic multisystemic JJ cord-028721-x6f26ahr 2881 8 X x NN cord-028721-x6f26ahr 2881 9 - - HYPH cord-028721-x6f26ahr 2881 10 linked link VBN cord-028721-x6f26ahr 2881 11 disease disease NN cord-028721-x6f26ahr 2881 12 . . . cord-028721-x6f26ahr 2882 1 It -PRON- PRP cord-028721-x6f26ahr 2882 2 is be VBZ cord-028721-x6f26ahr 2882 3 usually usually RB cord-028721-x6f26ahr 2882 4 associated associate VBN cord-028721-x6f26ahr 2882 5 with with IN cord-028721-x6f26ahr 2882 6 gonadal gonadal JJ cord-028721-x6f26ahr 2882 7 atrophy atrophy NN cord-028721-x6f26ahr 2882 8 caused cause VBN cord-028721-x6f26ahr 2882 9 by by IN cord-028721-x6f26ahr 2882 10 a a DT cord-028721-x6f26ahr 2882 11 defective defective JJ cord-028721-x6f26ahr 2882 12 locus locus NN cord-028721-x6f26ahr 2882 13 in in IN cord-028721-x6f26ahr 2882 14 chromosome chromosome NN cord-028721-x6f26ahr 2882 15 19 19 CD cord-028721-x6f26ahr 2882 16 . . . cord-028721-x6f26ahr 2883 1 Patients patient NNS cord-028721-x6f26ahr 2883 2 rarely rarely RB cord-028721-x6f26ahr 2883 3 live live VBP cord-028721-x6f26ahr 2883 4 more more JJR cord-028721-x6f26ahr 2883 5 than than IN cord-028721-x6f26ahr 2883 6 20 20 CD cord-028721-x6f26ahr 2883 7 years year NNS cord-028721-x6f26ahr 2883 8 . . . cord-028721-x6f26ahr 2884 1 The the DT cord-028721-x6f26ahr 2884 2 incidence incidence NN cord-028721-x6f26ahr 2884 3 is be VBZ cord-028721-x6f26ahr 2884 4 approximately approximately RB cord-028721-x6f26ahr 2884 5 1 1 CD cord-028721-x6f26ahr 2884 6 in in IN cord-028721-x6f26ahr 2884 7 4000 4000 CD cord-028721-x6f26ahr 2884 8 live live JJ cord-028721-x6f26ahr 2884 9 births birth NNS cord-028721-x6f26ahr 2884 10 . . . cord-028721-x6f26ahr 2885 1 In in IN cord-028721-x6f26ahr 2885 2 both both DT cord-028721-x6f26ahr 2885 3 Duchenne Duchenne NNP cord-028721-x6f26ahr 2885 4 and and CC cord-028721-x6f26ahr 2885 5 Becker Becker NNP cord-028721-x6f26ahr 2885 6 forms form VBZ cord-028721-x6f26ahr 2885 7 the the DT cord-028721-x6f26ahr 2885 8 cause cause NN cord-028721-x6f26ahr 2885 9 is be VBZ cord-028721-x6f26ahr 2885 10 a a DT cord-028721-x6f26ahr 2885 11 defect defect NN cord-028721-x6f26ahr 2885 12 in in IN cord-028721-x6f26ahr 2885 13 the the DT cord-028721-x6f26ahr 2885 14 dystrophin dystrophin NN cord-028721-x6f26ahr 2885 15 gene gene NN cord-028721-x6f26ahr 2885 16 . . . cord-028721-x6f26ahr 2886 1 1234 1234 CD cord-028721-x6f26ahr 2886 2 , , , cord-028721-x6f26ahr 2886 3 1235 1235 CD cord-028721-x6f26ahr 2886 4 Bloom Bloom NNP cord-028721-x6f26ahr 2886 5 's 's POS cord-028721-x6f26ahr 2886 6 , , , cord-028721-x6f26ahr 2886 7 Rothmund Rothmund NNP cord-028721-x6f26ahr 2886 8 - - HYPH cord-028721-x6f26ahr 2886 9 Thomson Thomson NNP cord-028721-x6f26ahr 2886 10 , , , cord-028721-x6f26ahr 2886 11 and and CC cord-028721-x6f26ahr 2886 12 Werner Werner NNP cord-028721-x6f26ahr 2886 13 's 's POS cord-028721-x6f26ahr 2886 14 syndromes syndrome NNS cord-028721-x6f26ahr 2886 15 are be VBP cord-028721-x6f26ahr 2886 16 caused cause VBN cord-028721-x6f26ahr 2886 17 by by IN cord-028721-x6f26ahr 2886 18 a a DT cord-028721-x6f26ahr 2886 19 homozygous homozygous JJ cord-028721-x6f26ahr 2886 20 defect defect NN cord-028721-x6f26ahr 2886 21 in in IN cord-028721-x6f26ahr 2886 22 human human JJ cord-028721-x6f26ahr 2886 23 RECEQ RECEQ NNP cord-028721-x6f26ahr 2886 24 helicases helicase NNS cord-028721-x6f26ahr 2886 25 in in IN cord-028721-x6f26ahr 2886 26 chromosome chromosome NN cord-028721-x6f26ahr 2886 27 15 15 CD cord-028721-x6f26ahr 2886 28 . . . cord-028721-x6f26ahr 2887 1 Of of IN cord-028721-x6f26ahr 2887 2 the the DT cord-028721-x6f26ahr 2887 3 fi fi NN cord-028721-x6f26ahr 2887 4 ve ve NNP cord-028721-x6f26ahr 2887 5 members member NNS cord-028721-x6f26ahr 2887 6 of of IN cord-028721-x6f26ahr 2887 7 this this DT cord-028721-x6f26ahr 2887 8 gene gene NN cord-028721-x6f26ahr 2887 9 family family NN cord-028721-x6f26ahr 2887 10 ( ( -LRB- cord-028721-x6f26ahr 2887 11 RECQ1 recq1 NN cord-028721-x6f26ahr 2887 12 , , , cord-028721-x6f26ahr 2887 13 BLM BLM NNP cord-028721-x6f26ahr 2887 14 , , , cord-028721-x6f26ahr 2887 15 WRN WRN NNP cord-028721-x6f26ahr 2887 16 , , , cord-028721-x6f26ahr 2887 17 RECQ4 RECQ4 NNP cord-028721-x6f26ahr 2887 18 , , , cord-028721-x6f26ahr 2887 19 and and CC cord-028721-x6f26ahr 2887 20 RECQ5 RECQ5 NNP cord-028721-x6f26ahr 2887 21 ) ) -RRB- cord-028721-x6f26ahr 2887 22 , , , cord-028721-x6f26ahr 2887 23 three three CD cord-028721-x6f26ahr 2887 24 produce produce VBP cord-028721-x6f26ahr 2887 25 autosomal autosomal JJ cord-028721-x6f26ahr 2887 26 recessive recessive JJ cord-028721-x6f26ahr 2887 27 inherited inherit VBN cord-028721-x6f26ahr 2887 28 diseases disease NNS cord-028721-x6f26ahr 2887 29 . . . cord-028721-x6f26ahr 2888 1 Mutations mutation NNS cord-028721-x6f26ahr 2888 2 of of IN cord-028721-x6f26ahr 2888 3 BLM BLM NNP cord-028721-x6f26ahr 2888 4 have have VBP cord-028721-x6f26ahr 2888 5 been be VBN cord-028721-x6f26ahr 2888 6 identifi identifi VBN cord-028721-x6f26ahr 2888 7 ed ed NN cord-028721-x6f26ahr 2888 8 in in IN cord-028721-x6f26ahr 2888 9 patients patient NNS cord-028721-x6f26ahr 2888 10 with with IN cord-028721-x6f26ahr 2888 11 Bloom Bloom NNP cord-028721-x6f26ahr 2888 12 's 's POS cord-028721-x6f26ahr 2888 13 syndrome syndrome NN cord-028721-x6f26ahr 2888 14 , , , cord-028721-x6f26ahr 2888 15 WRN WRN NNP cord-028721-x6f26ahr 2888 16 has have VBZ cord-028721-x6f26ahr 2888 17 been be VBN cord-028721-x6f26ahr 2888 18 shown show VBN cord-028721-x6f26ahr 2888 19 to to TO cord-028721-x6f26ahr 2888 20 be be VB cord-028721-x6f26ahr 2888 21 mutated mutate VBN cord-028721-x6f26ahr 2888 22 in in IN cord-028721-x6f26ahr 2888 23 Werner Werner NNP cord-028721-x6f26ahr 2888 24 's 's POS cord-028721-x6f26ahr 2888 25 syndrome syndrome NN cord-028721-x6f26ahr 2888 26 , , , cord-028721-x6f26ahr 2888 27 and and CC cord-028721-x6f26ahr 2888 28 mutations mutation NNS cord-028721-x6f26ahr 2888 29 of of IN cord-028721-x6f26ahr 2888 30 RecQ4 RecQ4 NNP cord-028721-x6f26ahr 2888 31 have have VBP cord-028721-x6f26ahr 2888 32 been be VBN cord-028721-x6f26ahr 2888 33 associated associate VBN cord-028721-x6f26ahr 2888 34 with with IN cord-028721-x6f26ahr 2888 35 Rothmund Rothmund NNP cord-028721-x6f26ahr 2888 36 - - HYPH cord-028721-x6f26ahr 2888 37 Thomson Thomson NNP cord-028721-x6f26ahr 2888 38 syndrome syndrome NN cord-028721-x6f26ahr 2888 39 . . . cord-028721-x6f26ahr 2889 1 1236 1236 CD cord-028721-x6f26ahr 2889 2 , , , cord-028721-x6f26ahr 2889 3 1237 1237 CD cord-028721-x6f26ahr 2890 1 Despite despite IN cord-028721-x6f26ahr 2890 2 the the DT cord-028721-x6f26ahr 2890 3 close close JJ cord-028721-x6f26ahr 2890 4 genetic genetic JJ cord-028721-x6f26ahr 2890 5 origin origin NN cord-028721-x6f26ahr 2890 6 of of IN cord-028721-x6f26ahr 2890 7 the the DT cord-028721-x6f26ahr 2890 8 three three CD cord-028721-x6f26ahr 2890 9 syndromes syndrome NNS cord-028721-x6f26ahr 2890 10 , , , cord-028721-x6f26ahr 2890 11 symptoms symptom NNS cord-028721-x6f26ahr 2890 12 are be VBP cord-028721-x6f26ahr 2890 13 very very RB cord-028721-x6f26ahr 2890 14 different different JJ cord-028721-x6f26ahr 2890 15 . . . cord-028721-x6f26ahr 2891 1 Bloom Bloom NNP cord-028721-x6f26ahr 2891 2 's 's POS cord-028721-x6f26ahr 2891 3 syndrome syndrome NN cord-028721-x6f26ahr 2891 4 is be VBZ cord-028721-x6f26ahr 2891 5 characterized characterize VBN cord-028721-x6f26ahr 2891 6 by by IN cord-028721-x6f26ahr 2891 7 short short JJ cord-028721-x6f26ahr 2891 8 stature stature NN cord-028721-x6f26ahr 2891 9 , , , cord-028721-x6f26ahr 2891 10 narrow narrow JJ cord-028721-x6f26ahr 2891 11 face face NN cord-028721-x6f26ahr 2891 12 with with IN cord-028721-x6f26ahr 2891 13 prominent prominent JJ cord-028721-x6f26ahr 2891 14 nose nose NN cord-028721-x6f26ahr 2891 15 , , , cord-028721-x6f26ahr 2891 16 facial facial JJ cord-028721-x6f26ahr 2891 17 ' ' `` cord-028721-x6f26ahr 2891 18 patchy patchy JJ cord-028721-x6f26ahr 2891 19 ' ' '' cord-028721-x6f26ahr 2891 20 skin skin NN cord-028721-x6f26ahr 2891 21 color color NN cord-028721-x6f26ahr 2891 22 changes change NNS cord-028721-x6f26ahr 2891 23 that that WDT cord-028721-x6f26ahr 2891 24 become become VBP cord-028721-x6f26ahr 2891 25 more more RBR cord-028721-x6f26ahr 2891 26 marked marked JJ cord-028721-x6f26ahr 2891 27 with with IN cord-028721-x6f26ahr 2891 28 sun sun NN cord-028721-x6f26ahr 2891 29 light light JJ cord-028721-x6f26ahr 2891 30 exposure exposure NN cord-028721-x6f26ahr 2891 31 , , , cord-028721-x6f26ahr 2891 32 and and CC cord-028721-x6f26ahr 2891 33 increased increase VBN cord-028721-x6f26ahr 2891 34 susceptibility susceptibility NN cord-028721-x6f26ahr 2891 35 to to IN cord-028721-x6f26ahr 2891 36 respiratory respiratory JJ cord-028721-x6f26ahr 2891 37 diseases disease NNS cord-028721-x6f26ahr 2891 38 , , , cord-028721-x6f26ahr 2891 39 cancer cancer NN cord-028721-x6f26ahr 2891 40 and and CC cord-028721-x6f26ahr 2891 41 leukemia leukemia NN cord-028721-x6f26ahr 2891 42 . . . cord-028721-x6f26ahr 2892 1 Severe severe JJ cord-028721-x6f26ahr 2892 2 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2892 3 and and CC cord-028721-x6f26ahr 2892 4 azoospermia azoospermia NN cord-028721-x6f26ahr 2892 5 are be VBP cord-028721-x6f26ahr 2892 6 common common JJ cord-028721-x6f26ahr 2892 7 . . . cord-028721-x6f26ahr 2893 1 Leydig leydig NN cord-028721-x6f26ahr 2893 2 cell cell NN cord-028721-x6f26ahr 2893 3 function function NN cord-028721-x6f26ahr 2893 4 is be VBZ cord-028721-x6f26ahr 2893 5 conserved conserve VBN cord-028721-x6f26ahr 2893 6 . . . cord-028721-x6f26ahr 2894 1 1238 1238 CD cord-028721-x6f26ahr 2894 2 Rothmund Rothmund NNP cord-028721-x6f26ahr 2894 3 - - HYPH cord-028721-x6f26ahr 2894 4 Thomson Thomson NNP cord-028721-x6f26ahr 2894 5 syndrome syndrome NN cord-028721-x6f26ahr 2894 6 presents present VBZ cord-028721-x6f26ahr 2894 7 with with IN cord-028721-x6f26ahr 2894 8 poikiloderma poikiloderma NNS cord-028721-x6f26ahr 2894 9 , , , cord-028721-x6f26ahr 2894 10 juvenile juvenile JJ cord-028721-x6f26ahr 2894 11 cataracts cataract NNS cord-028721-x6f26ahr 2894 12 , , , cord-028721-x6f26ahr 2894 13 sparse sparse JJ cord-028721-x6f26ahr 2894 14 hair hair NN cord-028721-x6f26ahr 2894 15 , , , cord-028721-x6f26ahr 2894 16 short short JJ cord-028721-x6f26ahr 2894 17 stature stature NN cord-028721-x6f26ahr 2894 18 , , , cord-028721-x6f26ahr 2894 19 skeletal skeletal JJ cord-028721-x6f26ahr 2894 20 defects defect NNS cord-028721-x6f26ahr 2894 21 , , , cord-028721-x6f26ahr 2894 22 dystrophic dystrophic JJ cord-028721-x6f26ahr 2894 23 teeth tooth NNS cord-028721-x6f26ahr 2894 24 and and CC cord-028721-x6f26ahr 2894 25 nails nail NNS cord-028721-x6f26ahr 2894 26 , , , cord-028721-x6f26ahr 2894 27 and and CC cord-028721-x6f26ahr 2894 28 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2894 29 . . . cord-028721-x6f26ahr 2895 1 These these DT cord-028721-x6f26ahr 2895 2 patients patient NNS cord-028721-x6f26ahr 2895 3 are be VBP cord-028721-x6f26ahr 2895 4 predisposed predisposed JJ cord-028721-x6f26ahr 2895 5 to to IN cord-028721-x6f26ahr 2895 6 cancer cancer NN cord-028721-x6f26ahr 2895 7 and and CC cord-028721-x6f26ahr 2895 8 osteogenic osteogenic JJ cord-028721-x6f26ahr 2895 9 sarcoma sarcoma NN cord-028721-x6f26ahr 2895 10 . . . cord-028721-x6f26ahr 2896 1 1239 1239 CD cord-028721-x6f26ahr 2897 1 Werner Werner NNP cord-028721-x6f26ahr 2897 2 's 's POS cord-028721-x6f26ahr 2897 3 syndrome syndrome NN cord-028721-x6f26ahr 2897 4 ( ( -LRB- cord-028721-x6f26ahr 2897 5 progeria progeria NNP cord-028721-x6f26ahr 2897 6 ) ) -RRB- cord-028721-x6f26ahr 2897 7 is be VBZ cord-028721-x6f26ahr 2897 8 characterized characterize VBN cord-028721-x6f26ahr 2897 9 by by IN cord-028721-x6f26ahr 2897 10 short short JJ cord-028721-x6f26ahr 2897 11 stature stature NN cord-028721-x6f26ahr 2897 12 , , , cord-028721-x6f26ahr 2897 13 prematurely prematurely RB cord-028721-x6f26ahr 2897 14 graying gray VBG cord-028721-x6f26ahr 2897 15 hair hair NN cord-028721-x6f26ahr 2897 16 , , , cord-028721-x6f26ahr 2897 17 baldness baldness NN cord-028721-x6f26ahr 2897 18 , , , cord-028721-x6f26ahr 2897 19 cataracts cataract NNS cord-028721-x6f26ahr 2897 20 , , , cord-028721-x6f26ahr 2897 21 atrophy atrophy NN cord-028721-x6f26ahr 2897 22 and and CC cord-028721-x6f26ahr 2897 23 calcifi calcifi NN cord-028721-x6f26ahr 2897 24 cation cation NN cord-028721-x6f26ahr 2897 25 of of IN cord-028721-x6f26ahr 2897 26 muscle muscle NN cord-028721-x6f26ahr 2897 27 and and CC cord-028721-x6f26ahr 2897 28 fat fat NN cord-028721-x6f26ahr 2897 29 , , , cord-028721-x6f26ahr 2897 30 wrinkling wrinkle VBG cord-028721-x6f26ahr 2897 31 of of IN cord-028721-x6f26ahr 2897 32 the the DT cord-028721-x6f26ahr 2897 33 skin skin NN cord-028721-x6f26ahr 2897 34 , , , cord-028721-x6f26ahr 2897 35 keratosis keratosis NN cord-028721-x6f26ahr 2897 36 , , , cord-028721-x6f26ahr 2897 37 osteoporosis osteoporosis NN cord-028721-x6f26ahr 2897 38 , , , cord-028721-x6f26ahr 2897 39 telangiectasis telangiectasis NNP cord-028721-x6f26ahr 2897 40 , , , cord-028721-x6f26ahr 2897 41 atheroma atheroma NNP cord-028721-x6f26ahr 2897 42 , , , cord-028721-x6f26ahr 2897 43 diabetes diabetes NN cord-028721-x6f26ahr 2897 44 mellitus mellitus NN cord-028721-x6f26ahr 2897 45 , , , cord-028721-x6f26ahr 2897 46 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2897 47 , , , cord-028721-x6f26ahr 2897 48 and and CC cord-028721-x6f26ahr 2897 49 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 2897 50 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2897 51 . . . cord-028721-x6f26ahr 2898 1 The the DT cord-028721-x6f26ahr 2898 2 lifespan lifespan NN cord-028721-x6f26ahr 2898 3 of of IN cord-028721-x6f26ahr 2898 4 fi fi NN cord-028721-x6f26ahr 2898 5 broblasts broblast NNS cord-028721-x6f26ahr 2898 6 and and CC cord-028721-x6f26ahr 2898 7 other other JJ cord-028721-x6f26ahr 2898 8 cells cell NNS cord-028721-x6f26ahr 2898 9 is be VBZ cord-028721-x6f26ahr 2898 10 shortened shorten VBN cord-028721-x6f26ahr 2898 11 in in IN cord-028721-x6f26ahr 2898 12 this this DT cord-028721-x6f26ahr 2898 13 syndrome syndrome NN cord-028721-x6f26ahr 2898 14 . . . cord-028721-x6f26ahr 2899 1 The the DT cord-028721-x6f26ahr 2899 2 mutation mutation NN cord-028721-x6f26ahr 2899 3 is be VBZ cord-028721-x6f26ahr 2899 4 in in IN cord-028721-x6f26ahr 2899 5 the the DT cord-028721-x6f26ahr 2899 6 RECQ3 RECQ3 NNP cord-028721-x6f26ahr 2899 7 helicase helicase NN cord-028721-x6f26ahr 2899 8 gene gene NN cord-028721-x6f26ahr 2899 9 . . . cord-028721-x6f26ahr 2900 1 Cockayne Cockayne NNP cord-028721-x6f26ahr 2900 2 's 's POS cord-028721-x6f26ahr 2900 3 syndrome syndrome NN cord-028721-x6f26ahr 2900 4 is be VBZ cord-028721-x6f26ahr 2900 5 a a DT cord-028721-x6f26ahr 2900 6 rare rare JJ cord-028721-x6f26ahr 2900 7 autosomal autosomal JJ cord-028721-x6f26ahr 2900 8 recessive recessive JJ cord-028721-x6f26ahr 2900 9 neurodegenerative neurodegenerative JJ cord-028721-x6f26ahr 2900 10 disorder disorder NN cord-028721-x6f26ahr 2900 11 . . . cord-028721-x6f26ahr 2901 1 Signs sign NNS cord-028721-x6f26ahr 2901 2 and and CC cord-028721-x6f26ahr 2901 3 symptoms symptom NNS cord-028721-x6f26ahr 2901 4 include include VBP cord-028721-x6f26ahr 2901 5 infantile infantile JJ cord-028721-x6f26ahr 2901 6 failure failure NN cord-028721-x6f26ahr 2901 7 to to TO cord-028721-x6f26ahr 2901 8 thrive thrive VB cord-028721-x6f26ahr 2901 9 , , , cord-028721-x6f26ahr 2901 10 short short JJ cord-028721-x6f26ahr 2901 11 stature stature NN cord-028721-x6f26ahr 2901 12 , , , cord-028721-x6f26ahr 2901 13 poorly poorly RB cord-028721-x6f26ahr 2901 14 developed develop VBN cord-028721-x6f26ahr 2901 15 trunk trunk NN cord-028721-x6f26ahr 2901 16 , , , cord-028721-x6f26ahr 2901 17 premature premature JJ cord-028721-x6f26ahr 2901 18 aging aging NN cord-028721-x6f26ahr 2901 19 , , , cord-028721-x6f26ahr 2901 20 neurological neurological JJ cord-028721-x6f26ahr 2901 21 alterations alteration NNS cord-028721-x6f26ahr 2901 22 , , , cord-028721-x6f26ahr 2901 23 retinitis retinitis NN cord-028721-x6f26ahr 2901 24 pigmentosa pigmentosa NN cord-028721-x6f26ahr 2901 25 , , , cord-028721-x6f26ahr 2901 26 optic optic JJ cord-028721-x6f26ahr 2901 27 atrophy atrophy NN cord-028721-x6f26ahr 2901 28 , , , cord-028721-x6f26ahr 2901 29 cataract cataract NN cord-028721-x6f26ahr 2901 30 , , , cord-028721-x6f26ahr 2901 31 deafness deafness NN cord-028721-x6f26ahr 2901 32 , , , cord-028721-x6f26ahr 2901 33 microcephaly microcephaly NNS cord-028721-x6f26ahr 2901 34 , , , cord-028721-x6f26ahr 2901 35 micrognathia micrognathia NNP cord-028721-x6f26ahr 2901 36 , , , cord-028721-x6f26ahr 2901 37 photosensitivity photosensitivity NN cord-028721-x6f26ahr 2901 38 , , , cord-028721-x6f26ahr 2901 39 delayed delay VBN cord-028721-x6f26ahr 2901 40 eruption eruption NN cord-028721-x6f26ahr 2901 41 of of IN cord-028721-x6f26ahr 2901 42 primary primary JJ cord-028721-x6f26ahr 2901 43 teeth tooth NNS cord-028721-x6f26ahr 2901 44 , , , cord-028721-x6f26ahr 2901 45 congenital congenital JJ cord-028721-x6f26ahr 2901 46 absence absence NN cord-028721-x6f26ahr 2901 47 of of IN cord-028721-x6f26ahr 2901 48 some some DT cord-028721-x6f26ahr 2901 49 permanent permanent JJ cord-028721-x6f26ahr 2901 50 teeth tooth NNS cord-028721-x6f26ahr 2901 51 , , , cord-028721-x6f26ahr 2901 52 partial partial JJ cord-028721-x6f26ahr 2901 53 macrodontia macrodontia NN cord-028721-x6f26ahr 2901 54 , , , cord-028721-x6f26ahr 2901 55 atrophy atrophy NN cord-028721-x6f26ahr 2901 56 of of IN cord-028721-x6f26ahr 2901 57 the the DT cord-028721-x6f26ahr 2901 58 alveolar alveolar NN cord-028721-x6f26ahr 2901 59 process process NN cord-028721-x6f26ahr 2901 60 and and CC cord-028721-x6f26ahr 2901 61 caries caries NN cord-028721-x6f26ahr 2901 62 , , , cord-028721-x6f26ahr 2901 63 limited limit VBN cord-028721-x6f26ahr 2901 64 articular articular JJ cord-028721-x6f26ahr 2901 65 movements movement NNS cord-028721-x6f26ahr 2901 66 in in IN cord-028721-x6f26ahr 2901 67 elbows elbow NNS cord-028721-x6f26ahr 2901 68 , , , cord-028721-x6f26ahr 2901 69 knees knee NNS cord-028721-x6f26ahr 2901 70 , , , cord-028721-x6f26ahr 2901 71 and and CC cord-028721-x6f26ahr 2901 72 fi fi NNP cord-028721-x6f26ahr 2901 73 ngers nger NNS cord-028721-x6f26ahr 2901 74 , , , cord-028721-x6f26ahr 2901 75 1240 1240 CD cord-028721-x6f26ahr 2901 76 abnormally abnormally RB cord-028721-x6f26ahr 2901 77 small small JJ cord-028721-x6f26ahr 2901 78 eccrine eccrine JJ cord-028721-x6f26ahr 2901 79 glands gland NNS cord-028721-x6f26ahr 2901 80 , , , cord-028721-x6f26ahr 2901 81 1241 1241 CD cord-028721-x6f26ahr 2901 82 and and CC cord-028721-x6f26ahr 2901 83 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 2901 84 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2901 85 . . . cord-028721-x6f26ahr 2902 1 It -PRON- PRP cord-028721-x6f26ahr 2902 2 may may MD cord-028721-x6f26ahr 2902 3 be be VB cord-028721-x6f26ahr 2902 4 caused cause VBN cord-028721-x6f26ahr 2902 5 by by IN cord-028721-x6f26ahr 2902 6 two two CD cord-028721-x6f26ahr 2902 7 gene gene NN cord-028721-x6f26ahr 2902 8 mutations mutation NNS cord-028721-x6f26ahr 2902 9 : : : cord-028721-x6f26ahr 2902 10 CNK1 CNK1 NNP cord-028721-x6f26ahr 2902 11 ( ( -LRB- cord-028721-x6f26ahr 2902 12 ERCC8 ERCC8 NNP cord-028721-x6f26ahr 2902 13 ) ) -RRB- cord-028721-x6f26ahr 2902 14 and and CC cord-028721-x6f26ahr 2902 15 ERCC6 ERCC6 NNS cord-028721-x6f26ahr 2902 16 , , , cord-028721-x6f26ahr 2902 17 located locate VBN cord-028721-x6f26ahr 2902 18 respectively respectively RB cord-028721-x6f26ahr 2902 19 on on IN cord-028721-x6f26ahr 2902 20 chromosomes chromosome NNS cord-028721-x6f26ahr 2902 21 5 5 CD cord-028721-x6f26ahr 2902 22 and and CC cord-028721-x6f26ahr 2902 23 10 10 CD cord-028721-x6f26ahr 2902 24 , , , cord-028721-x6f26ahr 2902 25 and and CC cord-028721-x6f26ahr 2902 26 causing cause VBG cord-028721-x6f26ahr 2902 27 two two CD cord-028721-x6f26ahr 2902 28 variations variation NNS cord-028721-x6f26ahr 2902 29 of of IN cord-028721-x6f26ahr 2902 30 Cockayne Cockayne NNP cord-028721-x6f26ahr 2902 31 's 's POS cord-028721-x6f26ahr 2902 32 syndrome syndrome NN cord-028721-x6f26ahr 2902 33 , , , cord-028721-x6f26ahr 2902 34 including include VBG cord-028721-x6f26ahr 2902 35 CS CS NNP cord-028721-x6f26ahr 2902 36 - - HYPH cord-028721-x6f26ahr 2902 37 A A NNP cord-028721-x6f26ahr 2902 38 , , , cord-028721-x6f26ahr 2902 39 secondary secondary JJ cord-028721-x6f26ahr 2902 40 to to IN cord-028721-x6f26ahr 2902 41 a a DT cord-028721-x6f26ahr 2902 42 ERCC8 ercc8 NN cord-028721-x6f26ahr 2902 43 mutation mutation NN cord-028721-x6f26ahr 2902 44 , , , cord-028721-x6f26ahr 2902 45 and and CC cord-028721-x6f26ahr 2902 46 CS CS NNP cord-028721-x6f26ahr 2902 47 - - HYPH cord-028721-x6f26ahr 2902 48 B B NNP cord-028721-x6f26ahr 2902 49 with with IN cord-028721-x6f26ahr 2902 50 ERCC6 ercc6 NN cord-028721-x6f26ahr 2902 51 mutation mutation NN cord-028721-x6f26ahr 2902 52 . . . cord-028721-x6f26ahr 2903 1 CS CS NNP cord-028721-x6f26ahr 2903 2 - - HYPH cord-028721-x6f26ahr 2903 3 B b NN cord-028721-x6f26ahr 2903 4 patients patient NNS cord-028721-x6f26ahr 2903 5 have have VBP cord-028721-x6f26ahr 2903 6 hypersensitivity hypersensitivity NN cord-028721-x6f26ahr 2903 7 to to IN cord-028721-x6f26ahr 2903 8 ultraviolet ultraviolet JJ cord-028721-x6f26ahr 2903 9 light light NN cord-028721-x6f26ahr 2903 10 secondary secondary JJ cord-028721-x6f26ahr 2903 11 to to IN cord-028721-x6f26ahr 2903 12 a a DT cord-028721-x6f26ahr 2903 13 DNA dna NN cord-028721-x6f26ahr 2903 14 repair repair NN cord-028721-x6f26ahr 2903 15 defect defect NN cord-028721-x6f26ahr 2903 16 . . . cord-028721-x6f26ahr 2904 1 1242 1242 CD cord-028721-x6f26ahr 2904 2 Tay Tay NNP cord-028721-x6f26ahr 2904 3 's 's POS cord-028721-x6f26ahr 2904 4 syndrome syndrome NN cord-028721-x6f26ahr 2904 5 ( ( -LRB- cord-028721-x6f26ahr 2904 6 trichothiodystrophy trichothiodystrophy NNP cord-028721-x6f26ahr 2904 7 ) ) -RRB- cord-028721-x6f26ahr 2904 8 has have VBZ cord-028721-x6f26ahr 2904 9 two two CD cord-028721-x6f26ahr 2904 10 presentations presentation NNS cord-028721-x6f26ahr 2904 11 : : : cord-028721-x6f26ahr 2904 12 IBSD IBSD NNP cord-028721-x6f26ahr 2904 13 ( ( -LRB- cord-028721-x6f26ahr 2904 14 ichthyosis ichthyosis NN cord-028721-x6f26ahr 2904 15 , , , cord-028721-x6f26ahr 2904 16 brittle brittle JJ cord-028721-x6f26ahr 2904 17 hair hair NN cord-028721-x6f26ahr 2904 18 , , , cord-028721-x6f26ahr 2904 19 impaired impair VBN cord-028721-x6f26ahr 2904 20 intelligence intelligence NN cord-028721-x6f26ahr 2904 21 , , , cord-028721-x6f26ahr 2904 22 short short JJ cord-028721-x6f26ahr 2904 23 stature stature NN cord-028721-x6f26ahr 2904 24 ) ) -RRB- cord-028721-x6f26ahr 2904 25 and and CC cord-028721-x6f26ahr 2904 26 IBISD IBISD NNP cord-028721-x6f26ahr 2904 27 ( ( -LRB- cord-028721-x6f26ahr 2904 28 photosensitivity photosensitivity NN cord-028721-x6f26ahr 2904 29 , , , cord-028721-x6f26ahr 2904 30 ichthyosis ichthyosis NN cord-028721-x6f26ahr 2904 31 , , , cord-028721-x6f26ahr 2904 32 brittle brittle JJ cord-028721-x6f26ahr 2904 33 hair hair NN cord-028721-x6f26ahr 2904 34 , , , cord-028721-x6f26ahr 2904 35 impaired impair VBN cord-028721-x6f26ahr 2904 36 intelligence intelligence NN cord-028721-x6f26ahr 2904 37 , , , cord-028721-x6f26ahr 2904 38 short short JJ cord-028721-x6f26ahr 2904 39 stature stature NN cord-028721-x6f26ahr 2904 40 ) ) -RRB- cord-028721-x6f26ahr 2904 41 . . . cord-028721-x6f26ahr 2905 1 In in IN cord-028721-x6f26ahr 2905 2 both both DT cord-028721-x6f26ahr 2905 3 forms form NNS cord-028721-x6f26ahr 2905 4 , , , cord-028721-x6f26ahr 2905 5 patients patient NNS cord-028721-x6f26ahr 2905 6 have have VBP cord-028721-x6f26ahr 2905 7 decreased decrease VBN cord-028721-x6f26ahr 2905 8 fertility fertility NN cord-028721-x6f26ahr 2905 9 . . . cord-028721-x6f26ahr 2906 1 One one CD cord-028721-x6f26ahr 2906 2 case case NN cord-028721-x6f26ahr 2906 3 of of IN cord-028721-x6f26ahr 2906 4 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 2906 5 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2906 6 has have VBZ cord-028721-x6f26ahr 2906 7 been be VBN cord-028721-x6f26ahr 2906 8 reported report VBN cord-028721-x6f26ahr 2906 9 . . . cord-028721-x6f26ahr 2907 1 1243 1243 CD cord-028721-x6f26ahr 2908 1 Noonan Noonan NNP cord-028721-x6f26ahr 2908 2 's 's POS cord-028721-x6f26ahr 2908 3 syndrome syndrome NN cord-028721-x6f26ahr 2908 4 is be VBZ cord-028721-x6f26ahr 2908 5 characterized characterize VBN cord-028721-x6f26ahr 2908 6 by by IN cord-028721-x6f26ahr 2908 7 multiple multiple JJ cord-028721-x6f26ahr 2908 8 malformations malformation NNS cord-028721-x6f26ahr 2908 9 reminiscent reminiscent JJ cord-028721-x6f26ahr 2908 10 of of IN cord-028721-x6f26ahr 2908 11 Turner Turner NNP cord-028721-x6f26ahr 2908 12 's 's POS cord-028721-x6f26ahr 2908 13 syndrome syndrome NN cord-028721-x6f26ahr 2908 14 , , , cord-028721-x6f26ahr 2908 15 including include VBG cord-028721-x6f26ahr 2908 16 short short JJ cord-028721-x6f26ahr 2908 17 statute statute NN cord-028721-x6f26ahr 2908 18 , , , cord-028721-x6f26ahr 2908 19 pterygium pterygium NN cord-028721-x6f26ahr 2908 20 coli coli NNS cord-028721-x6f26ahr 2908 21 , , , cord-028721-x6f26ahr 2908 22 and and CC cord-028721-x6f26ahr 2908 23 cubitus cubitus NNP cord-028721-x6f26ahr 2908 24 valgus valgus NNP cord-028721-x6f26ahr 2908 25 , , , cord-028721-x6f26ahr 2908 26 although although IN cord-028721-x6f26ahr 2908 27 there there EX cord-028721-x6f26ahr 2908 28 is be VBZ cord-028721-x6f26ahr 2908 29 normal normal JJ cord-028721-x6f26ahr 2908 30 male male JJ cord-028721-x6f26ahr 2908 31 karyotype karyotype NN cord-028721-x6f26ahr 2908 32 . . . cord-028721-x6f26ahr 2909 1 The the DT cord-028721-x6f26ahr 2909 2 disease disease NN cord-028721-x6f26ahr 2909 3 has have VBZ cord-028721-x6f26ahr 2909 4 an an DT cord-028721-x6f26ahr 2909 5 incidence incidence NN cord-028721-x6f26ahr 2909 6 of of IN cord-028721-x6f26ahr 2909 7 1 1 CD cord-028721-x6f26ahr 2909 8 in in IN cord-028721-x6f26ahr 2909 9 1000 1000 CD cord-028721-x6f26ahr 2909 10 to to IN cord-028721-x6f26ahr 2909 11 1 1 CD cord-028721-x6f26ahr 2909 12 in in IN cord-028721-x6f26ahr 2909 13 2500 2500 CD cord-028721-x6f26ahr 2909 14 live live JJ cord-028721-x6f26ahr 2909 15 births birth NNS cord-028721-x6f26ahr 2909 16 and and CC cord-028721-x6f26ahr 2909 17 autosomal autosomal JJ cord-028721-x6f26ahr 2909 18 dominant dominant JJ cord-028721-x6f26ahr 2909 19 inheritance inheritance NN cord-028721-x6f26ahr 2909 20 , , , cord-028721-x6f26ahr 2909 21 with with IN cord-028721-x6f26ahr 2909 22 sporadic sporadic JJ cord-028721-x6f26ahr 2909 23 occurrence occurrence NN cord-028721-x6f26ahr 2909 24 in in IN cord-028721-x6f26ahr 2909 25 about about RB cord-028721-x6f26ahr 2909 26 50 50 CD cord-028721-x6f26ahr 2909 27 % % NN cord-028721-x6f26ahr 2909 28 of of IN cord-028721-x6f26ahr 2909 29 cases case NNS cord-028721-x6f26ahr 2909 30 . . . cord-028721-x6f26ahr 2910 1 A a DT cord-028721-x6f26ahr 2910 2 locus locus NN cord-028721-x6f26ahr 2910 3 for for IN cord-028721-x6f26ahr 2910 4 dominant dominant JJ cord-028721-x6f26ahr 2910 5 forms form NNS cord-028721-x6f26ahr 2910 6 has have VBZ cord-028721-x6f26ahr 2910 7 been be VBN cord-028721-x6f26ahr 2910 8 mapped map VBN cord-028721-x6f26ahr 2910 9 to to IN cord-028721-x6f26ahr 2910 10 12q24.1 12q24.1 CD cord-028721-x6f26ahr 2910 11 . . . cord-028721-x6f26ahr 2911 1 1244 1244 CD cord-028721-x6f26ahr 2911 2 Mutation mutation NN cord-028721-x6f26ahr 2911 3 in in IN cord-028721-x6f26ahr 2911 4 PTPN11 ptpn11 XX cord-028721-x6f26ahr 2912 1 ( ( -LRB- cord-028721-x6f26ahr 2912 2 protein protein NN cord-028721-x6f26ahr 2912 3 - - HYPH cord-028721-x6f26ahr 2912 4 tyrosine tyrosine NN cord-028721-x6f26ahr 2912 5 phosphatase phosphatase NN cord-028721-x6f26ahr 2912 6 , , , cord-028721-x6f26ahr 2912 7 nonreceptor nonreceptor NN cord-028721-x6f26ahr 2912 8 - - HYPH cord-028721-x6f26ahr 2912 9 type type NN cord-028721-x6f26ahr 2912 10 11 11 CD cord-028721-x6f26ahr 2912 11 ) ) -RRB- cord-028721-x6f26ahr 2912 12 accounts account VBZ cord-028721-x6f26ahr 2912 13 for for IN cord-028721-x6f26ahr 2912 14 half half NN cord-028721-x6f26ahr 2912 15 of of IN cord-028721-x6f26ahr 2912 16 cases case NNS cord-028721-x6f26ahr 2912 17 , , , cord-028721-x6f26ahr 2912 18 although although IN cord-028721-x6f26ahr 2912 19 similar similar JJ cord-028721-x6f26ahr 2912 20 germline germline NN cord-028721-x6f26ahr 2912 21 mutations mutation NNS cord-028721-x6f26ahr 2912 22 also also RB cord-028721-x6f26ahr 2912 23 cause cause VBP cord-028721-x6f26ahr 2912 24 Leopard Leopard NNP cord-028721-x6f26ahr 2912 25 's 's POS cord-028721-x6f26ahr 2912 26 syndrome syndrome NN cord-028721-x6f26ahr 2912 27 and and CC cord-028721-x6f26ahr 2912 28 certain certain JJ cord-028721-x6f26ahr 2912 29 pediatric pediatric JJ cord-028721-x6f26ahr 2912 30 hematopoietic hematopoietic JJ cord-028721-x6f26ahr 2912 31 malignancies malignancy NNS cord-028721-x6f26ahr 2912 32 . . . cord-028721-x6f26ahr 2913 1 1245 1245 CD cord-028721-x6f26ahr 2914 1 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 2914 2 is be VBZ cord-028721-x6f26ahr 2914 3 present present JJ cord-028721-x6f26ahr 2914 4 in in IN cord-028721-x6f26ahr 2914 5 about about RB cord-028721-x6f26ahr 2914 6 70 70 CD cord-028721-x6f26ahr 2914 7 % % NN cord-028721-x6f26ahr 2914 8 of of IN cord-028721-x6f26ahr 2914 9 cases case NNS cord-028721-x6f26ahr 2914 10 and and CC cord-028721-x6f26ahr 2914 11 is be VBZ cord-028721-x6f26ahr 2914 12 usually usually RB cord-028721-x6f26ahr 2914 13 bilateral bilateral JJ cord-028721-x6f26ahr 2914 14 . . . cord-028721-x6f26ahr 2915 1 During during IN cord-028721-x6f26ahr 2915 2 childhood childhood NN cord-028721-x6f26ahr 2915 3 , , , cord-028721-x6f26ahr 2915 4 testicular testicular JJ cord-028721-x6f26ahr 2915 5 biopsy biopsy NN cord-028721-x6f26ahr 2915 6 shows show VBZ cord-028721-x6f26ahr 2915 7 a a DT cord-028721-x6f26ahr 2915 8 low low JJ cord-028721-x6f26ahr 2915 9 tubular tubular JJ cord-028721-x6f26ahr 2915 10 fertility fertility NN cord-028721-x6f26ahr 2915 11 index index NN cord-028721-x6f26ahr 2915 12 . . . cord-028721-x6f26ahr 2916 1 Puberty puberty NN cord-028721-x6f26ahr 2916 2 is be VBZ cord-028721-x6f26ahr 2916 3 often often RB cord-028721-x6f26ahr 2916 4 delayed delay VBN cord-028721-x6f26ahr 2916 5 , , , cord-028721-x6f26ahr 2916 6 and and CC cord-028721-x6f26ahr 2916 7 , , , cord-028721-x6f26ahr 2916 8 at at IN cord-028721-x6f26ahr 2916 9 adulthood adulthood NN cord-028721-x6f26ahr 2916 10 , , , cord-028721-x6f26ahr 2916 11 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2916 12 or or CC cord-028721-x6f26ahr 2916 13 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 2916 14 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2916 15 occurs occur VBZ cord-028721-x6f26ahr 2916 16 . . . cord-028721-x6f26ahr 2917 1 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 2917 2 studies study NNS cord-028721-x6f26ahr 2917 3 reveal reveal VBP cord-028721-x6f26ahr 2917 4 morphologic morphologic JJ cord-028721-x6f26ahr 2917 5 anomalies anomaly NNS cord-028721-x6f26ahr 2917 6 in in IN cord-028721-x6f26ahr 2917 7 germ germ NN cord-028721-x6f26ahr 2917 8 cells cell NNS cord-028721-x6f26ahr 2917 9 . . . cord-028721-x6f26ahr 2918 1 1246 1246 CD cord-028721-x6f26ahr 2919 1 Although although IN cord-028721-x6f26ahr 2919 2 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2919 3 is be VBZ cord-028721-x6f26ahr 2919 4 generally generally RB cord-028721-x6f26ahr 2919 5 impaired impair VBN cord-028721-x6f26ahr 2919 6 , , , cord-028721-x6f26ahr 2919 7 some some DT cord-028721-x6f26ahr 2919 8 patients patient NNS cord-028721-x6f26ahr 2919 9 have have VBP cord-028721-x6f26ahr 2919 10 been be VBN cord-028721-x6f26ahr 2919 11 fertile fertile JJ cord-028721-x6f26ahr 2919 12 ( ( -LRB- cord-028721-x6f26ahr 2919 13 Fig fig NN cord-028721-x6f26ahr 2919 14 . . . cord-028721-x6f26ahr 2919 15 _SP cord-028721-x6f26ahr 2920 1 12 12 CD cord-028721-x6f26ahr 2920 2 - - SYM cord-028721-x6f26ahr 2920 3 135 135 CD cord-028721-x6f26ahr 2920 4 ) ) -RRB- cord-028721-x6f26ahr 2920 5 . . . cord-028721-x6f26ahr 2921 1 Cerebellar cerebellar JJ cord-028721-x6f26ahr 2921 2 atrophy atrophy NN cord-028721-x6f26ahr 2921 3 may may MD cord-028721-x6f26ahr 2921 4 be be VB cord-028721-x6f26ahr 2921 5 associated associate VBN cord-028721-x6f26ahr 2921 6 with with IN cord-028721-x6f26ahr 2921 7 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2921 8 . . . cord-028721-x6f26ahr 2922 1 Patients patient NNS cord-028721-x6f26ahr 2922 2 are be VBP cord-028721-x6f26ahr 2922 3 infertile infertile JJ cord-028721-x6f26ahr 2922 4 and and CC cord-028721-x6f26ahr 2922 5 have have VBP cord-028721-x6f26ahr 2922 6 moderate moderate JJ cord-028721-x6f26ahr 2922 7 ataxia ataxia NN cord-028721-x6f26ahr 2922 8 without without IN cord-028721-x6f26ahr 2922 9 endocrine endocrine JJ cord-028721-x6f26ahr 2922 10 disorder disorder NN cord-028721-x6f26ahr 2922 11 . . . cord-028721-x6f26ahr 2923 1 Infertility infertility NN cord-028721-x6f26ahr 2923 2 is be VBZ cord-028721-x6f26ahr 2923 3 due due JJ cord-028721-x6f26ahr 2923 4 to to IN cord-028721-x6f26ahr 2923 5 morphological morphological JJ cord-028721-x6f26ahr 2923 6 abnormalities abnormality NNS cord-028721-x6f26ahr 2923 7 of of IN cord-028721-x6f26ahr 2923 8 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 2923 9 caused cause VBN cord-028721-x6f26ahr 2923 10 by by IN cord-028721-x6f26ahr 2923 11 decreased decreased JJ cord-028721-x6f26ahr 2923 12 expression expression NN cord-028721-x6f26ahr 2923 13 of of IN cord-028721-x6f26ahr 2923 14 MAP2 MAP2 NNP cord-028721-x6f26ahr 2923 15 ( ( -LRB- cord-028721-x6f26ahr 2923 16 the the DT cord-028721-x6f26ahr 2923 17 most most RBS cord-028721-x6f26ahr 2923 18 important important JJ cord-028721-x6f26ahr 2923 19 microtubule microtubule NN cord-028721-x6f26ahr 2923 20 - - HYPH cord-028721-x6f26ahr 2923 21 associated associate VBN cord-028721-x6f26ahr 2923 22 protein protein NN cord-028721-x6f26ahr 2923 23 ) ) -RRB- cord-028721-x6f26ahr 2923 24 , , , cord-028721-x6f26ahr 2923 25 and and CC cord-028721-x6f26ahr 2923 26 a a DT cord-028721-x6f26ahr 2923 27 defect defect NN cord-028721-x6f26ahr 2923 28 in in IN cord-028721-x6f26ahr 2923 29 erythroid erythroid JJ cord-028721-x6f26ahr 2923 30 ankyrin ankyrin NN cord-028721-x6f26ahr 2923 31 . . . cord-028721-x6f26ahr 2924 1 1247 1247 CD cord-028721-x6f26ahr 2924 2 , , , cord-028721-x6f26ahr 2924 3 1248 1248 CD cord-028721-x6f26ahr 2924 4 Many many JJ cord-028721-x6f26ahr 2924 5 other other JJ cord-028721-x6f26ahr 2924 6 syndromes syndrome NNS cord-028721-x6f26ahr 2924 7 also also RB cord-028721-x6f26ahr 2924 8 present present JJ cord-028721-x6f26ahr 2924 9 with with IN cord-028721-x6f26ahr 2924 10 primary primary JJ cord-028721-x6f26ahr 2924 11 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2924 12 . . . cord-028721-x6f26ahr 2925 1 The the DT cord-028721-x6f26ahr 2925 2 best well RBS cord-028721-x6f26ahr 2925 3 known know VBN cord-028721-x6f26ahr 2925 4 are be VBP cord-028721-x6f26ahr 2925 5 Alström Alström NNP cord-028721-x6f26ahr 2925 6 's 's POS cord-028721-x6f26ahr 2925 7 , , , cord-028721-x6f26ahr 2925 8 Weinstein Weinstein NNP cord-028721-x6f26ahr 2925 9 's 's POS cord-028721-x6f26ahr 2925 10 , , , cord-028721-x6f26ahr 2925 11 Borjenson Borjenson NNP cord-028721-x6f26ahr 2925 12 - - HYPH cord-028721-x6f26ahr 2925 13 Forssman Forssman NNP cord-028721-x6f26ahr 2925 14 - - HYPH cord-028721-x6f26ahr 2925 15 Lehmann Lehmann NNP cord-028721-x6f26ahr 2925 16 , , , cord-028721-x6f26ahr 2925 17 Marinesco Marinesco NNP cord-028721-x6f26ahr 2925 18 - - HYPH cord-028721-x6f26ahr 2925 19 Sjögren Sjögren NNP cord-028721-x6f26ahr 2925 20 , , , cord-028721-x6f26ahr 2925 21 Richards Richards NNP cord-028721-x6f26ahr 2925 22 - - HYPH cord-028721-x6f26ahr 2925 23 Rundle Rundle NNP cord-028721-x6f26ahr 2925 24 , , , cord-028721-x6f26ahr 2925 25 Robinow Robinow NNP cord-028721-x6f26ahr 2925 26 's 's POS cord-028721-x6f26ahr 2925 27 , , , cord-028721-x6f26ahr 2925 28 and and CC cord-028721-x6f26ahr 2925 29 Silver Silver NNP cord-028721-x6f26ahr 2925 30 - - HYPH cord-028721-x6f26ahr 2925 31 Russell Russell NNP cord-028721-x6f26ahr 2925 32 syndromes syndrome NNS cord-028721-x6f26ahr 2925 33 . . . cord-028721-x6f26ahr 2926 1 Hypogonadotropic Hypogonadotropic NNP cord-028721-x6f26ahr 2926 2 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2926 3 or or CC cord-028721-x6f26ahr 2926 4 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2926 5 of of IN cord-028721-x6f26ahr 2926 6 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 2926 7 - - HYPH cord-028721-x6f26ahr 2926 8 hypophyseal hypophyseal NNP cord-028721-x6f26ahr 2926 9 origin origin NN cord-028721-x6f26ahr 2926 10 is be VBZ cord-028721-x6f26ahr 2926 11 classifi classifi NNP cord-028721-x6f26ahr 2926 12 ed ed NNP cord-028721-x6f26ahr 2927 1 according accord VBG cord-028721-x6f26ahr 2927 2 to to IN cord-028721-x6f26ahr 2927 3 whether whether IN cord-028721-x6f26ahr 2927 4 the the DT cord-028721-x6f26ahr 2927 5 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 2927 6 - - HYPH cord-028721-x6f26ahr 2927 7 hypophyseal hypophyseal NNP cord-028721-x6f26ahr 2927 8 failure failure NN cord-028721-x6f26ahr 2927 9 occurs occur VBZ cord-028721-x6f26ahr 2927 10 before before IN cord-028721-x6f26ahr 2927 11 or or CC cord-028721-x6f26ahr 2927 12 after after IN cord-028721-x6f26ahr 2927 13 puberty puberty NN cord-028721-x6f26ahr 2927 14 . . . cord-028721-x6f26ahr 2928 1 Eunuchoidism Eunuchoidism NNP cord-028721-x6f26ahr 2928 2 , , , cord-028721-x6f26ahr 2928 3 present present JJ cord-028721-x6f26ahr 2928 4 only only RB cord-028721-x6f26ahr 2928 5 in in IN cord-028721-x6f26ahr 2928 6 the the DT cord-028721-x6f26ahr 2928 7 former former JJ cord-028721-x6f26ahr 2928 8 group group NN cord-028721-x6f26ahr 2928 9 , , , cord-028721-x6f26ahr 2928 10 is be VBZ cord-028721-x6f26ahr 2928 11 the the DT cord-028721-x6f26ahr 2928 12 basis basis NN cord-028721-x6f26ahr 2928 13 of of IN cord-028721-x6f26ahr 2928 14 the the DT cord-028721-x6f26ahr 2928 15 distinction distinction NN cord-028721-x6f26ahr 2928 16 . . . cord-028721-x6f26ahr 2929 1 The the DT cord-028721-x6f26ahr 2929 2 most most RBS cord-028721-x6f26ahr 2929 3 frequent frequent JJ cord-028721-x6f26ahr 2929 4 types type NNS cord-028721-x6f26ahr 2929 5 of of IN cord-028721-x6f26ahr 2929 6 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2929 7 caused cause VBN cord-028721-x6f26ahr 2929 8 by by IN cord-028721-x6f26ahr 2929 9 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 2929 10 - - HYPH cord-028721-x6f26ahr 2929 11 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 2929 12 failure failure NN cord-028721-x6f26ahr 2929 13 are be VBP cord-028721-x6f26ahr 2929 14 those those DT cord-028721-x6f26ahr 2929 15 caused cause VBN cord-028721-x6f26ahr 2929 16 by by IN cord-028721-x6f26ahr 2929 17 a a DT cord-028721-x6f26ahr 2929 18 defi defi NNP cord-028721-x6f26ahr 2929 19 cit cit NNP cord-028721-x6f26ahr 2929 20 of of IN cord-028721-x6f26ahr 2929 21 gonadotropinreleasing gonadotropinrelease VBG cord-028721-x6f26ahr 2929 22 hormone hormone NN cord-028721-x6f26ahr 2929 23 , , , cord-028721-x6f26ahr 2929 24 bioinactive bioinactive NNP cord-028721-x6f26ahr 2929 25 FSH FSH NNP cord-028721-x6f26ahr 2929 26 and and CC cord-028721-x6f26ahr 2929 27 LH LH NNP cord-028721-x6f26ahr 2929 28 , , , cord-028721-x6f26ahr 2929 29 defi defi NNP cord-028721-x6f26ahr 2929 30 cit cit NNP cord-028721-x6f26ahr 2929 31 in in IN cord-028721-x6f26ahr 2929 32 growth growth NN cord-028721-x6f26ahr 2929 33 hormone hormone NN cord-028721-x6f26ahr 2929 34 , , , cord-028721-x6f26ahr 2929 35 those those DT cord-028721-x6f26ahr 2929 36 associated associate VBN cord-028721-x6f26ahr 2929 37 with with IN cord-028721-x6f26ahr 2929 38 Prader Prader NNP cord-028721-x6f26ahr 2929 39 - - HYPH cord-028721-x6f26ahr 2929 40 Willi Willi NNP cord-028721-x6f26ahr 2929 41 syndrome syndrome NN cord-028721-x6f26ahr 2929 42 , , , cord-028721-x6f26ahr 2929 43 and and CC cord-028721-x6f26ahr 2929 44 Laurence Laurence NNP cord-028721-x6f26ahr 2929 45 - - HYPH cord-028721-x6f26ahr 2929 46 Moon Moon NNP cord-028721-x6f26ahr 2929 47 - - HYPH cord-028721-x6f26ahr 2929 48 Rozabal Rozabal NNP cord-028721-x6f26ahr 2929 49 - - HYPH cord-028721-x6f26ahr 2929 50 Bardet Bardet NNP cord-028721-x6f26ahr 2929 51 - - HYPH cord-028721-x6f26ahr 2929 52 Biedl Biedl NNP cord-028721-x6f26ahr 2929 53 syndrome syndrome NN cord-028721-x6f26ahr 2929 54 . . . cord-028721-x6f26ahr 2930 1 The the DT cord-028721-x6f26ahr 2930 2 onset onset NN cord-028721-x6f26ahr 2930 3 and and CC cord-028721-x6f26ahr 2930 4 maintenance maintenance NN cord-028721-x6f26ahr 2930 5 of of IN cord-028721-x6f26ahr 2930 6 the the DT cord-028721-x6f26ahr 2930 7 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 2930 8 - - HYPH cord-028721-x6f26ahr 2930 9 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 2930 10 - - HYPH cord-028721-x6f26ahr 2930 11 gonadal gonadal JJ cord-028721-x6f26ahr 2930 12 axis axis NN cord-028721-x6f26ahr 2930 13 is be VBZ cord-028721-x6f26ahr 2930 14 due due JJ cord-028721-x6f26ahr 2930 15 to to IN cord-028721-x6f26ahr 2930 16 pulsatile pulsatile JJ cord-028721-x6f26ahr 2930 17 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2930 18 - - HYPH cord-028721-x6f26ahr 2930 19 releasing release VBG cord-028721-x6f26ahr 2930 20 hormone hormone NN cord-028721-x6f26ahr 2931 1 ( ( -LRB- cord-028721-x6f26ahr 2931 2 GnRH GnRH NNP cord-028721-x6f26ahr 2931 3 ) ) -RRB- cord-028721-x6f26ahr 2931 4 secretion secretion NN cord-028721-x6f26ahr 2931 5 by by IN cord-028721-x6f26ahr 2931 6 neurons neuron NNS cord-028721-x6f26ahr 2931 7 of of IN cord-028721-x6f26ahr 2931 8 the the DT cord-028721-x6f26ahr 2931 9 nucleus nucleus JJ cord-028721-x6f26ahr 2931 10 arcuatus arcuatus NNP cord-028721-x6f26ahr 2931 11 hypothalamus hypothalamus NNP cord-028721-x6f26ahr 2931 12 , , , cord-028721-x6f26ahr 2931 13 with with IN cord-028721-x6f26ahr 2931 14 release release NN cord-028721-x6f26ahr 2931 15 into into IN cord-028721-x6f26ahr 2931 16 the the DT cord-028721-x6f26ahr 2931 17 pituitary pituitary JJ cord-028721-x6f26ahr 2931 18 portal portal NN cord-028721-x6f26ahr 2931 19 system system NN cord-028721-x6f26ahr 2931 20 and and CC cord-028721-x6f26ahr 2931 21 subsequent subsequent JJ cord-028721-x6f26ahr 2931 22 stimulation stimulation NN cord-028721-x6f26ahr 2931 23 of of IN cord-028721-x6f26ahr 2931 24 gonadotropinreleasing gonadotropinrelease VBG cord-028721-x6f26ahr 2931 25 hormone hormone NN cord-028721-x6f26ahr 2931 26 receptors receptor NNS cord-028721-x6f26ahr 2931 27 on on IN cord-028721-x6f26ahr 2931 28 the the DT cord-028721-x6f26ahr 2931 29 surface surface NN cord-028721-x6f26ahr 2931 30 of of IN cord-028721-x6f26ahr 2931 31 gonadotropinsecreting gonadotropinsecreting NN cord-028721-x6f26ahr 2931 32 cells cell NNS cord-028721-x6f26ahr 2931 33 . . . cord-028721-x6f26ahr 2932 1 The the DT cord-028721-x6f26ahr 2932 2 GnRH GnRH NNP cord-028721-x6f26ahr 2932 3 gene gene NN cord-028721-x6f26ahr 2932 4 is be VBZ cord-028721-x6f26ahr 2932 5 located locate VBN cord-028721-x6f26ahr 2932 6 on on IN cord-028721-x6f26ahr 2932 7 4q13 4q13 CD cord-028721-x6f26ahr 2932 8 . . . cord-028721-x6f26ahr 2933 1 1249 1249 CD cord-028721-x6f26ahr 2933 2 Patients patient NNS cord-028721-x6f26ahr 2933 3 with with IN cord-028721-x6f26ahr 2933 4 GnRH GnRH NNP cord-028721-x6f26ahr 2933 5 defi defi NNP cord-028721-x6f26ahr 2933 6 cit cit NNP cord-028721-x6f26ahr 2933 7 have have VBP cord-028721-x6f26ahr 2933 8 partial partial JJ cord-028721-x6f26ahr 2933 9 or or CC cord-028721-x6f26ahr 2933 10 complete complete JJ cord-028721-x6f26ahr 2933 11 absence absence NN cord-028721-x6f26ahr 2933 12 of of IN cord-028721-x6f26ahr 2933 13 GnRH gnrh NN cord-028721-x6f26ahr 2933 14 - - HYPH cord-028721-x6f26ahr 2933 15 induced induce VBN cord-028721-x6f26ahr 2933 16 pulsatile pulsatile JJ cord-028721-x6f26ahr 2933 17 LH LH NNP cord-028721-x6f26ahr 2933 18 secretion secretion NN cord-028721-x6f26ahr 2933 19 , , , cord-028721-x6f26ahr 2933 20 and and CC cord-028721-x6f26ahr 2933 21 normalization normalization NN cord-028721-x6f26ahr 2933 22 of of IN cord-028721-x6f26ahr 2933 23 pituitary pituitary NN cord-028721-x6f26ahr 2933 24 and and CC cord-028721-x6f26ahr 2933 25 gonadal gonadal JJ cord-028721-x6f26ahr 2933 26 secretions secretion NNS cord-028721-x6f26ahr 2933 27 after after IN cord-028721-x6f26ahr 2933 28 exogenous exogenous JJ cord-028721-x6f26ahr 2933 29 GnRH GnRH NNP cord-028721-x6f26ahr 2933 30 administration administration NN cord-028721-x6f26ahr 2933 31 . . . cord-028721-x6f26ahr 2934 1 Imaging imaging NN cord-028721-x6f26ahr 2934 2 studies study NNS cord-028721-x6f26ahr 2934 3 of of IN cord-028721-x6f26ahr 2934 4 the the DT cord-028721-x6f26ahr 2934 5 hypothalamo hypothalamo NNP cord-028721-x6f26ahr 2934 6 - - HYPH cord-028721-x6f26ahr 2934 7 hypophyseal hypophyseal NNP cord-028721-x6f26ahr 2934 8 region region NN cord-028721-x6f26ahr 2934 9 are be VBP cord-028721-x6f26ahr 2934 10 normal normal JJ cord-028721-x6f26ahr 2934 11 . . . cord-028721-x6f26ahr 2935 1 Clinical clinical JJ cord-028721-x6f26ahr 2935 2 symptoms symptom NNS cord-028721-x6f26ahr 2935 3 vary vary VBP cord-028721-x6f26ahr 2935 4 with with IN cord-028721-x6f26ahr 2935 5 age age NN cord-028721-x6f26ahr 2935 6 at at IN cord-028721-x6f26ahr 2935 7 presentation presentation NN cord-028721-x6f26ahr 2935 8 ( ( -LRB- cord-028721-x6f26ahr 2935 9 congenital congenital JJ cord-028721-x6f26ahr 2935 10 or or CC cord-028721-x6f26ahr 2935 11 acquired acquire VBN cord-028721-x6f26ahr 2935 12 ) ) -RRB- cord-028721-x6f26ahr 2935 13 and and CC cord-028721-x6f26ahr 2935 14 severity severity NN cord-028721-x6f26ahr 2935 15 ( ( -LRB- cord-028721-x6f26ahr 2935 16 complete complete JJ cord-028721-x6f26ahr 2935 17 or or CC cord-028721-x6f26ahr 2935 18 partial partial JJ cord-028721-x6f26ahr 2935 19 defi defi NNP cord-028721-x6f26ahr 2935 20 cit cit NNP cord-028721-x6f26ahr 2935 21 ) ) -RRB- cord-028721-x6f26ahr 2935 22 . . . cord-028721-x6f26ahr 2936 1 Clinical clinical JJ cord-028721-x6f26ahr 2936 2 presentations presentation NNS cord-028721-x6f26ahr 2936 3 include include VBP cord-028721-x6f26ahr 2936 4 delayed delay VBN cord-028721-x6f26ahr 2936 5 puberty puberty NN cord-028721-x6f26ahr 2936 6 , , , cord-028721-x6f26ahr 2936 7 idiopathic idiopathic JJ cord-028721-x6f26ahr 2936 8 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2936 9 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2936 10 ( ( -LRB- cord-028721-x6f26ahr 2936 11 isolated isolate VBN cord-028721-x6f26ahr 2936 12 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2936 13 defi defi NNP cord-028721-x6f26ahr 2936 14 cit cit NNP cord-028721-x6f26ahr 2936 15 ) ) -RRB- cord-028721-x6f26ahr 2936 16 , , , cord-028721-x6f26ahr 2936 17 Kallmann Kallmann NNP cord-028721-x6f26ahr 2936 18 's 's POS cord-028721-x6f26ahr 2936 19 syndrome syndrome NN cord-028721-x6f26ahr 2936 20 , , , cord-028721-x6f26ahr 2936 21 isolated isolate VBN cord-028721-x6f26ahr 2936 22 FSH FSH NNP cord-028721-x6f26ahr 2936 23 defi defi NNP cord-028721-x6f26ahr 2936 24 cit cit NNP cord-028721-x6f26ahr 2936 25 , , , cord-028721-x6f26ahr 2936 26 and and CC cord-028721-x6f26ahr 2936 27 isolated isolate VBN cord-028721-x6f26ahr 2936 28 LH LH NNP cord-028721-x6f26ahr 2936 29 defi defi NNP cord-028721-x6f26ahr 2936 30 cit cit NNP cord-028721-x6f26ahr 2936 31 ( ( -LRB- cord-028721-x6f26ahr 2936 32 fertile fertile JJ cord-028721-x6f26ahr 2936 33 eunuch eunuch NNP cord-028721-x6f26ahr 2936 34 syndrome syndrome NN cord-028721-x6f26ahr 2936 35 ) ) -RRB- cord-028721-x6f26ahr 2936 36 . . . cord-028721-x6f26ahr 2937 1 Constitutional constitutional JJ cord-028721-x6f26ahr 2937 2 delayed delay VBN cord-028721-x6f26ahr 2937 3 puberty puberty NN cord-028721-x6f26ahr 2937 4 is be VBZ cord-028721-x6f26ahr 2937 5 assumed assume VBN cord-028721-x6f26ahr 2937 6 to to TO cord-028721-x6f26ahr 2937 7 be be VB cord-028721-x6f26ahr 2937 8 a a DT cord-028721-x6f26ahr 2937 9 minor minor JJ cord-028721-x6f26ahr 2937 10 form form NN cord-028721-x6f26ahr 2937 11 of of IN cord-028721-x6f26ahr 2937 12 GnRH GnRH NNP cord-028721-x6f26ahr 2937 13 defi defi NNP cord-028721-x6f26ahr 2937 14 cit cit NNP cord-028721-x6f26ahr 2937 15 , , , cord-028721-x6f26ahr 2937 16 1250 1250 CD cord-028721-x6f26ahr 2937 17 and and CC cord-028721-x6f26ahr 2937 18 is be VBZ cord-028721-x6f26ahr 2937 19 characterized characterize VBN cord-028721-x6f26ahr 2937 20 by by IN cord-028721-x6f26ahr 2937 21 delayed delay VBN cord-028721-x6f26ahr 2937 22 sexual sexual JJ cord-028721-x6f26ahr 2937 23 maturation maturation NN cord-028721-x6f26ahr 2937 24 in in IN cord-028721-x6f26ahr 2937 25 otherwise otherwise RB cord-028721-x6f26ahr 2937 26 healthy healthy JJ cord-028721-x6f26ahr 2937 27 males male NNS cord-028721-x6f26ahr 2937 28 . . . cord-028721-x6f26ahr 2938 1 Patients patient NNS cord-028721-x6f26ahr 2938 2 are be VBP cord-028721-x6f26ahr 2938 3 short short JJ cord-028721-x6f26ahr 2938 4 and and CC cord-028721-x6f26ahr 2938 5 usually usually RB cord-028721-x6f26ahr 2938 6 have have VBP cord-028721-x6f26ahr 2938 7 a a DT cord-028721-x6f26ahr 2938 8 family family NN cord-028721-x6f26ahr 2938 9 history history NN cord-028721-x6f26ahr 2938 10 of of IN cord-028721-x6f26ahr 2938 11 delayed delay VBN cord-028721-x6f26ahr 2938 12 puberty puberty NN cord-028721-x6f26ahr 2938 13 . . . cord-028721-x6f26ahr 2939 1 Puberty puberty NN cord-028721-x6f26ahr 2939 2 usually usually RB cord-028721-x6f26ahr 2939 3 begins begin VBZ cord-028721-x6f26ahr 2939 4 at at IN cord-028721-x6f26ahr 2939 5 13 13 CD cord-028721-x6f26ahr 2939 6 - - SYM cord-028721-x6f26ahr 2939 7 14 14 CD cord-028721-x6f26ahr 2939 8 years year NNS cord-028721-x6f26ahr 2939 9 of of IN cord-028721-x6f26ahr 2939 10 age age NN cord-028721-x6f26ahr 2939 11 and and CC cord-028721-x6f26ahr 2939 12 progresses progress VBZ cord-028721-x6f26ahr 2939 13 over over IN cord-028721-x6f26ahr 2939 14 2 2 CD cord-028721-x6f26ahr 2939 15 years year NNS cord-028721-x6f26ahr 2939 16 . . . cord-028721-x6f26ahr 2940 1 If if IN cord-028721-x6f26ahr 2940 2 a a DT cord-028721-x6f26ahr 2940 3 14-year 14-year JJ cord-028721-x6f26ahr 2940 4 - - HYPH cord-028721-x6f26ahr 2940 5 old old JJ cord-028721-x6f26ahr 2940 6 boy boy NN cord-028721-x6f26ahr 2940 7 has have VBZ cord-028721-x6f26ahr 2940 8 not not RB cord-028721-x6f26ahr 2940 9 begun begin VBN cord-028721-x6f26ahr 2940 10 pubertal pubertal JJ cord-028721-x6f26ahr 2940 11 changes change NNS cord-028721-x6f26ahr 2940 12 ( ( -LRB- cord-028721-x6f26ahr 2940 13 testicular testicular JJ cord-028721-x6f26ahr 2940 14 enlargement enlargement NN cord-028721-x6f26ahr 2940 15 , , , cord-028721-x6f26ahr 2940 16 growth growth NN cord-028721-x6f26ahr 2940 17 in in IN cord-028721-x6f26ahr 2940 18 height height NN cord-028721-x6f26ahr 2940 19 , , , cord-028721-x6f26ahr 2940 20 and and CC cord-028721-x6f26ahr 2940 21 development development NN cord-028721-x6f26ahr 2940 22 of of IN cord-028721-x6f26ahr 2940 23 secondary secondary JJ cord-028721-x6f26ahr 2940 24 sex sex NN cord-028721-x6f26ahr 2940 25 characteristics characteristic NNS cord-028721-x6f26ahr 2940 26 ) ) -RRB- cord-028721-x6f26ahr 2940 27 , , , cord-028721-x6f26ahr 2940 28 delayed delay VBN cord-028721-x6f26ahr 2940 29 puberty puberty NN cord-028721-x6f26ahr 2940 30 should should MD cord-028721-x6f26ahr 2940 31 be be VB cord-028721-x6f26ahr 2940 32 suspected suspect VBN cord-028721-x6f26ahr 2940 33 . . . cord-028721-x6f26ahr 2941 1 1251 1251 CD cord-028721-x6f26ahr 2942 1 Simple simple JJ cord-028721-x6f26ahr 2942 2 pubertal pubertal JJ cord-028721-x6f26ahr 2942 3 delay delay NN cord-028721-x6f26ahr 2942 4 that that WDT cord-028721-x6f26ahr 2942 5 is be VBZ cord-028721-x6f26ahr 2942 6 overcome overcome VBN cord-028721-x6f26ahr 2942 7 naturally naturally RB cord-028721-x6f26ahr 2942 8 in in IN cord-028721-x6f26ahr 2942 9 a a DT cord-028721-x6f26ahr 2942 10 short short JJ cord-028721-x6f26ahr 2942 11 time time NN cord-028721-x6f26ahr 2942 12 without without IN cord-028721-x6f26ahr 2942 13 treatment treatment NN cord-028721-x6f26ahr 2942 14 must must MD cord-028721-x6f26ahr 2942 15 be be VB cord-028721-x6f26ahr 2942 16 distinguished distinguish VBN cord-028721-x6f26ahr 2942 17 from from IN cord-028721-x6f26ahr 2942 18 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2942 19 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2942 20 . . . cord-028721-x6f26ahr 2943 1 The the DT cord-028721-x6f26ahr 2943 2 latter latter JJ cord-028721-x6f26ahr 2943 3 should should MD cord-028721-x6f26ahr 2943 4 be be VB cord-028721-x6f26ahr 2943 5 suspected suspect VBN cord-028721-x6f26ahr 2943 6 when when WRB cord-028721-x6f26ahr 2943 7 any any DT cord-028721-x6f26ahr 2943 8 of of IN cord-028721-x6f26ahr 2943 9 the the DT cord-028721-x6f26ahr 2943 10 following follow VBG cord-028721-x6f26ahr 2943 11 symptoms symptom NNS cord-028721-x6f26ahr 2943 12 are be VBP cord-028721-x6f26ahr 2943 13 present present JJ cord-028721-x6f26ahr 2943 14 in in IN cord-028721-x6f26ahr 2943 15 the the DT cord-028721-x6f26ahr 2943 16 patient patient NN cord-028721-x6f26ahr 2943 17 or or CC cord-028721-x6f26ahr 2943 18 his -PRON- PRP$ cord-028721-x6f26ahr 2943 19 family family NN cord-028721-x6f26ahr 2943 20 : : : cord-028721-x6f26ahr 2943 21 a a DT cord-028721-x6f26ahr 2943 22 midline midline JJ cord-028721-x6f26ahr 2943 23 defect defect NN cord-028721-x6f26ahr 2943 24 , , , cord-028721-x6f26ahr 2943 25 anosmia anosmia NN cord-028721-x6f26ahr 2943 26 , , , cord-028721-x6f26ahr 2943 27 or or CC cord-028721-x6f26ahr 2943 28 pubic pubic JJ cord-028721-x6f26ahr 2943 29 hair hair NN cord-028721-x6f26ahr 2943 30 without without IN cord-028721-x6f26ahr 2943 31 testicular testicular JJ cord-028721-x6f26ahr 2943 32 development development NN cord-028721-x6f26ahr 2943 33 . . . cord-028721-x6f26ahr 2944 1 Hormone hormone NN cord-028721-x6f26ahr 2944 2 assays assay NNS cord-028721-x6f26ahr 2944 3 may may MD cord-028721-x6f26ahr 2944 4 also also RB cord-028721-x6f26ahr 2944 5 assist assist VB cord-028721-x6f26ahr 2944 6 in in IN cord-028721-x6f26ahr 2944 7 diagnosis diagnosis NN cord-028721-x6f26ahr 2944 8 . . . cord-028721-x6f26ahr 2945 1 If if IN cord-028721-x6f26ahr 2945 2 a a DT cord-028721-x6f26ahr 2945 3 patient patient NN cord-028721-x6f26ahr 2945 4 between between IN cord-028721-x6f26ahr 2945 5 16 16 CD cord-028721-x6f26ahr 2945 6 and and CC cord-028721-x6f26ahr 2945 7 18 18 CD cord-028721-x6f26ahr 2945 8 years year NNS cord-028721-x6f26ahr 2945 9 old old JJ cord-028721-x6f26ahr 2945 10 has have VBZ cord-028721-x6f26ahr 2945 11 prepubertal prepubertal JJ cord-028721-x6f26ahr 2945 12 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 2945 13 levels level NNS cord-028721-x6f26ahr 2945 14 , , , cord-028721-x6f26ahr 2945 15 he -PRON- PRP cord-028721-x6f26ahr 2945 16 probably probably RB cord-028721-x6f26ahr 2945 17 has have VBZ cord-028721-x6f26ahr 2945 18 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2945 19 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2945 20 . . . cord-028721-x6f26ahr 2946 1 A a DT cord-028721-x6f26ahr 2946 2 variant variant NN cord-028721-x6f26ahr 2946 3 of of IN cord-028721-x6f26ahr 2946 4 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2946 5 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2946 6 , , , cord-028721-x6f26ahr 2946 7 isolated isolate VBN cord-028721-x6f26ahr 2946 8 gonadotropin gonadotropin NN cord-028721-x6f26ahr 2946 9 defi defi NNP cord-028721-x6f26ahr 2946 10 cit cit NNP cord-028721-x6f26ahr 2946 11 is be VBZ cord-028721-x6f26ahr 2946 12 characterized characterize VBN cord-028721-x6f26ahr 2946 13 by by IN cord-028721-x6f26ahr 2946 14 defects defect NNS cord-028721-x6f26ahr 2946 15 in in IN cord-028721-x6f26ahr 2946 16 the the DT cord-028721-x6f26ahr 2946 17 synthesis synthesis NN cord-028721-x6f26ahr 2946 18 or or CC cord-028721-x6f26ahr 2946 19 release release NN cord-028721-x6f26ahr 2946 20 of of IN cord-028721-x6f26ahr 2946 21 FSH fsh NN cord-028721-x6f26ahr 2946 22 and and CC cord-028721-x6f26ahr 2946 23 LH LH NNP cord-028721-x6f26ahr 2946 24 ; ; : cord-028721-x6f26ahr 2946 25 other other JJ cord-028721-x6f26ahr 2946 26 hypophyseal hypophyseal NN cord-028721-x6f26ahr 2946 27 functions function NNS cord-028721-x6f26ahr 2946 28 are be VBP cord-028721-x6f26ahr 2946 29 normal normal JJ cord-028721-x6f26ahr 2946 30 . . . cord-028721-x6f26ahr 2947 1 Patients patient NNS cord-028721-x6f26ahr 2947 2 have have VBP cord-028721-x6f26ahr 2947 3 eunuchoid eunuchoid JJ cord-028721-x6f26ahr 2947 4 phenotype phenotype NN cord-028721-x6f26ahr 2947 5 , , , cord-028721-x6f26ahr 2947 6 with with IN cord-028721-x6f26ahr 2947 7 small small JJ cord-028721-x6f26ahr 2947 8 testes testis NNS cord-028721-x6f26ahr 2947 9 and and CC cord-028721-x6f26ahr 2947 10 penis penis NN cord-028721-x6f26ahr 2947 11 , , , cord-028721-x6f26ahr 2947 12 scanty scanty JJ cord-028721-x6f26ahr 2947 13 body body NN cord-028721-x6f26ahr 2947 14 hair hair NN cord-028721-x6f26ahr 2947 15 and and CC cord-028721-x6f26ahr 2947 16 beard beard NN cord-028721-x6f26ahr 2947 17 , , , cord-028721-x6f26ahr 2947 18 a a DT cord-028721-x6f26ahr 2947 19 high high RB cord-028721-x6f26ahr 2947 20 - - HYPH cord-028721-x6f26ahr 2947 21 pitched pitch VBN cord-028721-x6f26ahr 2947 22 voice voice NN cord-028721-x6f26ahr 2947 23 , , , cord-028721-x6f26ahr 2947 24 and and CC cord-028721-x6f26ahr 2947 25 poorly poorly RB cord-028721-x6f26ahr 2947 26 developed develop VBN cord-028721-x6f26ahr 2947 27 muscles muscle NNS cord-028721-x6f26ahr 2947 28 . . . cord-028721-x6f26ahr 2948 1 Presentation presentation NN cord-028721-x6f26ahr 2948 2 may may MD cord-028721-x6f26ahr 2948 3 be be VB cord-028721-x6f26ahr 2948 4 sporadic sporadic JJ cord-028721-x6f26ahr 2948 5 , , , cord-028721-x6f26ahr 2948 6 autosomal autosomal JJ cord-028721-x6f26ahr 2948 7 dominant dominant JJ cord-028721-x6f26ahr 2948 8 , , , cord-028721-x6f26ahr 2948 9 autosomal autosomal JJ cord-028721-x6f26ahr 2948 10 recessive recessive JJ cord-028721-x6f26ahr 2948 11 , , , cord-028721-x6f26ahr 2948 12 or or CC cord-028721-x6f26ahr 2948 13 Xlinked Xlinked NNP cord-028721-x6f26ahr 2948 14 . . . cord-028721-x6f26ahr 2949 1 The the DT cord-028721-x6f26ahr 2949 2 cause cause NN cord-028721-x6f26ahr 2949 3 might may MD cord-028721-x6f26ahr 2949 4 be be VB cord-028721-x6f26ahr 2949 5 a a DT cord-028721-x6f26ahr 2949 6 mutation mutation NN cord-028721-x6f26ahr 2949 7 in in IN cord-028721-x6f26ahr 2949 8 the the DT cord-028721-x6f26ahr 2949 9 GnRH GnRH NNP cord-028721-x6f26ahr 2949 10 receptor receptor NN cord-028721-x6f26ahr 2949 11 gene gene NN cord-028721-x6f26ahr 2949 12 . . . cord-028721-x6f26ahr 2950 1 1252 1252 CD cord-028721-x6f26ahr 2950 2 Patients patient NNS cord-028721-x6f26ahr 2950 3 have have VBP cord-028721-x6f26ahr 2950 4 very very RB cord-028721-x6f26ahr 2950 5 low low JJ cord-028721-x6f26ahr 2950 6 levels level NNS cord-028721-x6f26ahr 2950 7 of of IN cord-028721-x6f26ahr 2950 8 FSH fsh NN cord-028721-x6f26ahr 2950 9 , , , cord-028721-x6f26ahr 2950 10 LH lh NN cord-028721-x6f26ahr 2950 11 , , , cord-028721-x6f26ahr 2950 12 testosterone testosterone NN cord-028721-x6f26ahr 2950 13 , , , cord-028721-x6f26ahr 2950 14 and and CC cord-028721-x6f26ahr 2950 15 estrogen estrogen NN cord-028721-x6f26ahr 2950 16 . . . cord-028721-x6f26ahr 2951 1 Clomiphene Clomiphene NNP cord-028721-x6f26ahr 2951 2 citrate citrate NN cord-028721-x6f26ahr 2951 3 treatment treatment NN cord-028721-x6f26ahr 2951 4 fails fail VBZ cord-028721-x6f26ahr 2951 5 to to TO cord-028721-x6f26ahr 2951 6 stimulate stimulate VB cord-028721-x6f26ahr 2951 7 hormonal hormonal JJ cord-028721-x6f26ahr 2951 8 secretion secretion NN cord-028721-x6f26ahr 2951 9 . . . cord-028721-x6f26ahr 2952 1 1253 1253 CD cord-028721-x6f26ahr 2953 1 Pulsatile Pulsatile NNP cord-028721-x6f26ahr 2953 2 administration administration NN cord-028721-x6f26ahr 2953 3 of of IN cord-028721-x6f26ahr 2953 4 GnRH GnRH NNP cord-028721-x6f26ahr 2953 5 is be VBZ cord-028721-x6f26ahr 2953 6 useful useful JJ cord-028721-x6f26ahr 2953 7 to to TO cord-028721-x6f26ahr 2953 8 promote promote VB cord-028721-x6f26ahr 2953 9 both both CC cord-028721-x6f26ahr 2953 10 androgen androgen JJR cord-028721-x6f26ahr 2953 11 production production NN cord-028721-x6f26ahr 2953 12 and and CC cord-028721-x6f26ahr 2953 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2953 14 . . . cord-028721-x6f26ahr 2954 1 The the DT cord-028721-x6f26ahr 2954 2 LH LH NNP cord-028721-x6f26ahr 2954 3 - - HYPH cord-028721-x6f26ahr 2954 4 Leydig leydig NN cord-028721-x6f26ahr 2954 5 cell cell NN cord-028721-x6f26ahr 2954 6 - - HYPH cord-028721-x6f26ahr 2954 7 testosterone testosterone NN cord-028721-x6f26ahr 2954 8 axis axis NN cord-028721-x6f26ahr 2954 9 is be VBZ cord-028721-x6f26ahr 2954 10 normal normal JJ cord-028721-x6f26ahr 2954 11 in in IN cord-028721-x6f26ahr 2954 12 most most JJS cord-028721-x6f26ahr 2954 13 cases case NNS cord-028721-x6f26ahr 2954 14 , , , cord-028721-x6f26ahr 2954 15 but but CC cord-028721-x6f26ahr 2954 16 normalization normalization NN cord-028721-x6f26ahr 2954 17 of of IN cord-028721-x6f26ahr 2954 18 the the DT cord-028721-x6f26ahr 2954 19 FSH FSH NNP cord-028721-x6f26ahr 2954 20 - - HYPH cord-028721-x6f26ahr 2954 21 Sertoli Sertoli NNP cord-028721-x6f26ahr 2954 22 cell cell NN cord-028721-x6f26ahr 2954 23 - - HYPH cord-028721-x6f26ahr 2954 24 inhibin inhibin NN cord-028721-x6f26ahr 2954 25 axis axis NN cord-028721-x6f26ahr 2954 26 is be VBZ cord-028721-x6f26ahr 2954 27 not not RB cord-028721-x6f26ahr 2954 28 achieved achieve VBN cord-028721-x6f26ahr 2954 29 in in IN cord-028721-x6f26ahr 2954 30 all all DT cord-028721-x6f26ahr 2954 31 cases case NNS cord-028721-x6f26ahr 2954 32 . . . cord-028721-x6f26ahr 2955 1 Basal basal NN cord-028721-x6f26ahr 2955 2 inhibin inhibin NN cord-028721-x6f26ahr 2955 3 levels level NNS cord-028721-x6f26ahr 2955 4 higher high JJR cord-028721-x6f26ahr 2955 5 than than IN cord-028721-x6f26ahr 2955 6 60 60 CD cord-028721-x6f26ahr 2955 7 pg pg NN cord-028721-x6f26ahr 2955 8 / / SYM cord-028721-x6f26ahr 2955 9 mL ml NN cord-028721-x6f26ahr 2955 10 and and CC cord-028721-x6f26ahr 2955 11 absence absence NN cord-028721-x6f26ahr 2955 12 of of IN cord-028721-x6f26ahr 2955 13 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2955 14 are be VBP cord-028721-x6f26ahr 2955 15 favorable favorable JJ cord-028721-x6f26ahr 2955 16 predictor predictor NN cord-028721-x6f26ahr 2955 17 factors factor NNS cord-028721-x6f26ahr 2955 18 for for IN cord-028721-x6f26ahr 2955 19 the the DT cord-028721-x6f26ahr 2955 20 acquisition acquisition NN cord-028721-x6f26ahr 2955 21 of of IN cord-028721-x6f26ahr 2955 22 normal normal JJ cord-028721-x6f26ahr 2955 23 testicular testicular JJ cord-028721-x6f26ahr 2955 24 size size NN cord-028721-x6f26ahr 2955 25 and and CC cord-028721-x6f26ahr 2955 26 acceptable acceptable JJ cord-028721-x6f26ahr 2955 27 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2955 28 . . . cord-028721-x6f26ahr 2956 1 1254 1254 CD cord-028721-x6f26ahr 2957 1 Testicular testicular JJ cord-028721-x6f26ahr 2957 2 biopsy biopsy NN cord-028721-x6f26ahr 2957 3 reveals reveal VBZ cord-028721-x6f26ahr 2957 4 an an DT cord-028721-x6f26ahr 2957 5 immature immature JJ cord-028721-x6f26ahr 2957 6 pattern pattern NN cord-028721-x6f26ahr 2957 7 . . . cord-028721-x6f26ahr 2958 1 The the DT cord-028721-x6f26ahr 2958 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 2958 3 tubules tubule NNS cord-028721-x6f26ahr 2958 4 have have VBP cord-028721-x6f26ahr 2958 5 neither neither CC cord-028721-x6f26ahr 2958 6 lumina lumina NNP cord-028721-x6f26ahr 2958 7 nor nor CC cord-028721-x6f26ahr 2958 8 elastic elastic JJ cord-028721-x6f26ahr 2958 9 fi fi NN cord-028721-x6f26ahr 2958 10 bers ber NNS cord-028721-x6f26ahr 2958 11 ( ( -LRB- cord-028721-x6f26ahr 2958 12 Fig Fig NNP cord-028721-x6f26ahr 2958 13 . . . cord-028721-x6f26ahr 2958 14 _SP cord-028721-x6f26ahr 2959 1 12 12 CD cord-028721-x6f26ahr 2959 2 - - SYM cord-028721-x6f26ahr 2959 3 136 136 CD cord-028721-x6f26ahr 2959 4 ) ) -RRB- cord-028721-x6f26ahr 2959 5 . . . cord-028721-x6f26ahr 2960 1 Sertoli sertoli JJ cord-028721-x6f26ahr 2960 2 cells cell NNS cord-028721-x6f26ahr 2960 3 are be VBP cord-028721-x6f26ahr 2960 4 immature immature JJ cord-028721-x6f26ahr 2960 5 , , , cord-028721-x6f26ahr 2960 6 and and CC cord-028721-x6f26ahr 2960 7 no no DT cord-028721-x6f26ahr 2960 8 differentiated differentiated JJ cord-028721-x6f26ahr 2960 9 Leydig Leydig NNP cord-028721-x6f26ahr 2960 10 cells cell NNS cord-028721-x6f26ahr 2960 11 are be VBP cord-028721-x6f26ahr 2960 12 seen see VBN cord-028721-x6f26ahr 2960 13 . . . cord-028721-x6f26ahr 2961 1 Spermatogonia Spermatogonia NNP cord-028721-x6f26ahr 2961 2 are be VBP cord-028721-x6f26ahr 2961 3 rare rare JJ cord-028721-x6f26ahr 2961 4 . . . cord-028721-x6f26ahr 2962 1 In in IN cord-028721-x6f26ahr 2962 2 some some DT cord-028721-x6f26ahr 2962 3 patients patient NNS cord-028721-x6f26ahr 2962 4 the the DT cord-028721-x6f26ahr 2962 5 pattern pattern NN cord-028721-x6f26ahr 2962 6 is be VBZ cord-028721-x6f26ahr 2962 7 similar similar JJ cord-028721-x6f26ahr 2962 8 to to IN cord-028721-x6f26ahr 2962 9 that that DT cord-028721-x6f26ahr 2962 10 of of IN cord-028721-x6f26ahr 2962 11 Sertoli sertoli JJ cord-028721-x6f26ahr 2962 12 cell cell NN cord-028721-x6f26ahr 2962 13 - - HYPH cord-028721-x6f26ahr 2962 14 only only RB cord-028721-x6f26ahr 2962 15 testes testis NNS cord-028721-x6f26ahr 2962 16 with with IN cord-028721-x6f26ahr 2962 17 immature immature JJ cord-028721-x6f26ahr 2962 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 2962 19 cells cell NNS cord-028721-x6f26ahr 2962 20 . . . cord-028721-x6f26ahr 2963 1 1255 1255 CD cord-028721-x6f26ahr 2963 2 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 2963 3 associated associate VBN cord-028721-x6f26ahr 2963 4 with with IN cord-028721-x6f26ahr 2963 5 anosmia anosmia NN cord-028721-x6f26ahr 2963 6 is be VBZ cord-028721-x6f26ahr 2963 7 also also RB cord-028721-x6f26ahr 2963 8 known know VBN cord-028721-x6f26ahr 2963 9 as as IN cord-028721-x6f26ahr 2963 10 Maestre Maestre NNP cord-028721-x6f26ahr 2963 11 de de FW cord-028721-x6f26ahr 2963 12 San San NNP cord-028721-x6f26ahr 2963 13 Juan Juan NNP cord-028721-x6f26ahr 2963 14 , , , cord-028721-x6f26ahr 2963 15 1256 1256 CD cord-028721-x6f26ahr 2963 16 Kallman Kallman NNP cord-028721-x6f26ahr 2963 17 , , , cord-028721-x6f26ahr 2963 18 1257 1257 CD cord-028721-x6f26ahr 2963 19 abnormalities abnormality NNS cord-028721-x6f26ahr 2963 20 include include VBP cord-028721-x6f26ahr 2963 21 olfactory olfactory JJ cord-028721-x6f26ahr 2963 22 bulb bulb NN cord-028721-x6f26ahr 2963 23 agenesis agenesis NN cord-028721-x6f26ahr 2963 24 , , , cord-028721-x6f26ahr 2963 25 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 2963 26 , , , cord-028721-x6f26ahr 2963 27 mental mental JJ cord-028721-x6f26ahr 2963 28 retardation retardation NN cord-028721-x6f26ahr 2963 29 , , , cord-028721-x6f26ahr 2963 30 color color NN cord-028721-x6f26ahr 2963 31 blindness blindness NN cord-028721-x6f26ahr 2963 32 , , , cord-028721-x6f26ahr 2963 33 facial facial JJ cord-028721-x6f26ahr 2963 34 asymmetry asymmetry NN cord-028721-x6f26ahr 2963 35 , , , cord-028721-x6f26ahr 2963 36 nerve nerve NN cord-028721-x6f26ahr 2963 37 deafness deafness NN cord-028721-x6f26ahr 2963 38 , , , cord-028721-x6f26ahr 2963 39 epilepsy epilepsy NN cord-028721-x6f26ahr 2963 40 , , , cord-028721-x6f26ahr 2963 41 shortening shortening NN cord-028721-x6f26ahr 2963 42 of of IN cord-028721-x6f26ahr 2963 43 the the DT cord-028721-x6f26ahr 2963 44 fourth fourth JJ cord-028721-x6f26ahr 2963 45 metacarpal metacarpal NN cord-028721-x6f26ahr 2963 46 , , , cord-028721-x6f26ahr 2963 47 tarsal tarsal NN cord-028721-x6f26ahr 2963 48 navicular navicular NNP cord-028721-x6f26ahr 2963 49 fi fi NNP cord-028721-x6f26ahr 2963 50 brous brous JJ cord-028721-x6f26ahr 2963 51 dysplasia dysplasia NN cord-028721-x6f26ahr 2963 52 , , , cord-028721-x6f26ahr 2963 53 familial familial JJ cord-028721-x6f26ahr 2963 54 cerebellar cerebellar JJ cord-028721-x6f26ahr 2963 55 ataxia ataxia NN cord-028721-x6f26ahr 2963 56 , , , cord-028721-x6f26ahr 2963 57 diabetes diabetes NN cord-028721-x6f26ahr 2963 58 mellitus mellitus NN cord-028721-x6f26ahr 2963 59 , , , cord-028721-x6f26ahr 2963 60 hyperlipidemia hyperlipidemia NN cord-028721-x6f26ahr 2963 61 , , , cord-028721-x6f26ahr 2963 62 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2963 63 , , , cord-028721-x6f26ahr 2963 64 cleft cleft NN cord-028721-x6f26ahr 2963 65 lip lip NN cord-028721-x6f26ahr 2963 66 , , , cord-028721-x6f26ahr 2963 67 maxillary maxillary JJ cord-028721-x6f26ahr 2963 68 or or CC cord-028721-x6f26ahr 2963 69 palate palate NN cord-028721-x6f26ahr 2963 70 , , , cord-028721-x6f26ahr 2963 71 unilateral unilateral JJ cord-028721-x6f26ahr 2963 72 renal renal JJ cord-028721-x6f26ahr 2963 73 aplasia aplasia NNP cord-028721-x6f26ahr 2963 74 , , , cord-028721-x6f26ahr 2963 75 and and CC cord-028721-x6f26ahr 2963 76 cardiovascular cardiovascular JJ cord-028721-x6f26ahr 2963 77 abnormalities abnormality NNS cord-028721-x6f26ahr 2963 78 . . . cord-028721-x6f26ahr 2964 1 The the DT cord-028721-x6f26ahr 2964 2 syndrome syndrome NN cord-028721-x6f26ahr 2964 3 may may MD cord-028721-x6f26ahr 2964 4 be be VB cord-028721-x6f26ahr 2964 5 Xlinked xlinked JJ cord-028721-x6f26ahr 2964 6 or or CC cord-028721-x6f26ahr 2964 7 autosomal autosomal JJ cord-028721-x6f26ahr 2964 8 . . . cord-028721-x6f26ahr 2965 1 The the DT cord-028721-x6f26ahr 2965 2 gene gene NN cord-028721-x6f26ahr 2965 3 for for IN cord-028721-x6f26ahr 2965 4 the the DT cord-028721-x6f26ahr 2965 5 X x NN cord-028721-x6f26ahr 2965 6 - - HYPH cord-028721-x6f26ahr 2965 7 linked link VBN cord-028721-x6f26ahr 2965 8 form form NN cord-028721-x6f26ahr 2965 9 is be VBZ cord-028721-x6f26ahr 2965 10 mapped map VBN cord-028721-x6f26ahr 2965 11 to to IN cord-028721-x6f26ahr 2965 12 Xp22.3 Xp22.3 NNP cord-028721-x6f26ahr 2965 13 and and CC cord-028721-x6f26ahr 2965 14 may may MD cord-028721-x6f26ahr 2965 15 have have VB cord-028721-x6f26ahr 2965 16 different different JJ cord-028721-x6f26ahr 2965 17 mutations mutation NNS cord-028721-x6f26ahr 2965 18 ( ( -LRB- cord-028721-x6f26ahr 2965 19 termed term VBN cord-028721-x6f26ahr 2965 20 Kal Kal NNP cord-028721-x6f26ahr 2965 21 - - HYPH cord-028721-x6f26ahr 2965 22 X X NNP cord-028721-x6f26ahr 2965 23 , , , cord-028721-x6f26ahr 2965 24 KALIG-1 KALIG-1 NNP cord-028721-x6f26ahr 2965 25 , , , cord-028721-x6f26ahr 2965 26 and and CC cord-028721-x6f26ahr 2965 27 ADMLX ADMLX NNP cord-028721-x6f26ahr 2965 28 ) ) -RRB- cord-028721-x6f26ahr 2965 29 , , , cord-028721-x6f26ahr 2965 30 complete complete JJ cord-028721-x6f26ahr 2965 31 deletion deletion NN cord-028721-x6f26ahr 2965 32 , , , cord-028721-x6f26ahr 2965 33 and and CC cord-028721-x6f26ahr 2965 34 point point NN cord-028721-x6f26ahr 2965 35 mutations mutation NNS cord-028721-x6f26ahr 2965 36 . . . cord-028721-x6f26ahr 2966 1 This this DT cord-028721-x6f26ahr 2966 2 gene gene NN cord-028721-x6f26ahr 2966 3 encodes encode VBZ cord-028721-x6f26ahr 2966 4 the the DT cord-028721-x6f26ahr 2966 5 protein protein NN cord-028721-x6f26ahr 2966 6 anosmina-1 anosmina-1 NNP cord-028721-x6f26ahr 2966 7 , , , cord-028721-x6f26ahr 2966 8 which which WDT cord-028721-x6f26ahr 2966 9 is be VBZ cord-028721-x6f26ahr 2966 10 similar similar JJ cord-028721-x6f26ahr 2966 11 to to IN cord-028721-x6f26ahr 2966 12 other other JJ cord-028721-x6f26ahr 2966 13 nerve nerve NN cord-028721-x6f26ahr 2966 14 cell cell NN cord-028721-x6f26ahr 2966 15 adhesion adhesion NN cord-028721-x6f26ahr 2966 16 molecules molecule NNS cord-028721-x6f26ahr 2966 17 and and CC cord-028721-x6f26ahr 2966 18 is be VBZ cord-028721-x6f26ahr 2966 19 involved involve VBN cord-028721-x6f26ahr 2966 20 in in IN cord-028721-x6f26ahr 2966 21 axonal axonal JJ cord-028721-x6f26ahr 2966 22 growth growth NN cord-028721-x6f26ahr 2966 23 and and CC cord-028721-x6f26ahr 2966 24 development development NN cord-028721-x6f26ahr 2966 25 . . . cord-028721-x6f26ahr 2967 1 KAL KAL NNP cord-028721-x6f26ahr 2967 2 protein protein NN cord-028721-x6f26ahr 2967 3 , , , cord-028721-x6f26ahr 2967 4 secreted secrete VBN cord-028721-x6f26ahr 2967 5 by by IN cord-028721-x6f26ahr 2967 6 mitral mitral JJ cord-028721-x6f26ahr 2967 7 cells cell NNS cord-028721-x6f26ahr 2967 8 , , , cord-028721-x6f26ahr 2967 9 permits permit VBZ cord-028721-x6f26ahr 2967 10 the the DT cord-028721-x6f26ahr 2967 11 passage passage NN cord-028721-x6f26ahr 2967 12 of of IN cord-028721-x6f26ahr 2967 13 olfactory olfactory JJ cord-028721-x6f26ahr 2967 14 neurons neuron NNS cord-028721-x6f26ahr 2967 15 into into IN cord-028721-x6f26ahr 2967 16 the the DT cord-028721-x6f26ahr 2967 17 olfactory olfactory JJ cord-028721-x6f26ahr 2967 18 bulbs bulb NNS cord-028721-x6f26ahr 2967 19 and and CC cord-028721-x6f26ahr 2967 20 is be VBZ cord-028721-x6f26ahr 2967 21 lacking lack VBG cord-028721-x6f26ahr 2967 22 in in IN cord-028721-x6f26ahr 2967 23 Kallmann Kallmann NNP cord-028721-x6f26ahr 2967 24 's 's POS cord-028721-x6f26ahr 2967 25 syndrome syndrome NN cord-028721-x6f26ahr 2967 26 . . . cord-028721-x6f26ahr 2968 1 This this DT cord-028721-x6f26ahr 2968 2 failure failure NN cord-028721-x6f26ahr 2968 3 also also RB cord-028721-x6f26ahr 2968 4 inhibits inhibit VBZ cord-028721-x6f26ahr 2968 5 migration migration NN cord-028721-x6f26ahr 2968 6 of of IN cord-028721-x6f26ahr 2968 7 neuroblasts neuroblast NNS cord-028721-x6f26ahr 2968 8 from from IN cord-028721-x6f26ahr 2968 9 the the DT cord-028721-x6f26ahr 2968 10 olfactory olfactory JJ cord-028721-x6f26ahr 2968 11 epithelium epithelium NN cord-028721-x6f26ahr 2968 12 to to IN cord-028721-x6f26ahr 2968 13 the the DT cord-028721-x6f26ahr 2968 14 hypothalamus hypothalamus NN cord-028721-x6f26ahr 2968 15 to to TO cord-028721-x6f26ahr 2968 16 form form VB cord-028721-x6f26ahr 2968 17 GnRH GnRH NNP cord-028721-x6f26ahr 2968 18 - - HYPH cord-028721-x6f26ahr 2968 19 secreting secrete VBG cord-028721-x6f26ahr 2968 20 neurons neuron NNS cord-028721-x6f26ahr 2968 21 . . . cord-028721-x6f26ahr 2969 1 1259 1259 CD cord-028721-x6f26ahr 2970 1 The the DT cord-028721-x6f26ahr 2970 2 autosomal autosomal JJ cord-028721-x6f26ahr 2970 3 dominant dominant JJ cord-028721-x6f26ahr 2970 4 presentation presentation NN cord-028721-x6f26ahr 2970 5 ( ( -LRB- cord-028721-x6f26ahr 2970 6 occurring occur VBG cord-028721-x6f26ahr 2970 7 in in IN cord-028721-x6f26ahr 2970 8 10 10 CD cord-028721-x6f26ahr 2970 9 % % NN cord-028721-x6f26ahr 2970 10 of of IN cord-028721-x6f26ahr 2970 11 cases case NNS cord-028721-x6f26ahr 2970 12 ) ) -RRB- cord-028721-x6f26ahr 2970 13 is be VBZ cord-028721-x6f26ahr 2970 14 due due JJ cord-028721-x6f26ahr 2970 15 to to IN cord-028721-x6f26ahr 2970 16 loss loss NN cord-028721-x6f26ahr 2970 17 of of IN cord-028721-x6f26ahr 2970 18 function function NN cord-028721-x6f26ahr 2970 19 of of IN cord-028721-x6f26ahr 2970 20 fi fi NN cord-028721-x6f26ahr 2970 21 broblastic broblastic JJ cord-028721-x6f26ahr 2970 22 growth growth NN cord-028721-x6f26ahr 2970 23 factor factor NN cord-028721-x6f26ahr 2970 24 receptor receptor NN cord-028721-x6f26ahr 2970 25 1 1 CD cord-028721-x6f26ahr 2970 26 ( ( -LRB- cord-028721-x6f26ahr 2970 27 FGFR1 FGFR1 NNP cord-028721-x6f26ahr 2970 28 ) ) -RRB- cord-028721-x6f26ahr 2970 29 . . . cord-028721-x6f26ahr 2971 1 1260 1260 CD cord-028721-x6f26ahr 2971 2 Interaction Interaction NNP cord-028721-x6f26ahr 2971 3 between between IN cord-028721-x6f26ahr 2971 4 KAL1 KAL1 NNP cord-028721-x6f26ahr 2971 5 and and CC cord-028721-x6f26ahr 2971 6 FGFR1 FGFR1 NNP cord-028721-x6f26ahr 2971 7 is be VBZ cord-028721-x6f26ahr 2971 8 required require VBN cord-028721-x6f26ahr 2971 9 for for IN cord-028721-x6f26ahr 2971 10 neuronal neuronal JJ cord-028721-x6f26ahr 2971 11 migration migration NN cord-028721-x6f26ahr 2971 12 . . . cord-028721-x6f26ahr 2972 1 1261 1261 CD cord-028721-x6f26ahr 2973 1 Patients patient NNS cord-028721-x6f26ahr 2973 2 are be VBP cord-028721-x6f26ahr 2973 3 classifi classifi NNS cord-028721-x6f26ahr 2973 4 ed ed NN cord-028721-x6f26ahr 2973 5 into into IN cord-028721-x6f26ahr 2973 6 two two CD cord-028721-x6f26ahr 2973 7 groups group NNS cord-028721-x6f26ahr 2973 8 according accord VBG cord-028721-x6f26ahr 2973 9 to to IN cord-028721-x6f26ahr 2973 10 the the DT cord-028721-x6f26ahr 2973 11 partial partial JJ cord-028721-x6f26ahr 2973 12 or or CC cord-028721-x6f26ahr 2973 13 complete complete JJ cord-028721-x6f26ahr 2973 14 absence absence NN cord-028721-x6f26ahr 2973 15 of of IN cord-028721-x6f26ahr 2973 16 GnRH GnRH NNP cord-028721-x6f26ahr 2973 17 . . . cord-028721-x6f26ahr 2974 1 Partial partial JJ cord-028721-x6f26ahr 2974 2 absence absence NN cord-028721-x6f26ahr 2974 3 of of IN cord-028721-x6f26ahr 2974 4 GnRH GnRH NNP cord-028721-x6f26ahr 2974 5 is be VBZ cord-028721-x6f26ahr 2974 6 diagnosed diagnose VBN cord-028721-x6f26ahr 2974 7 by by IN cord-028721-x6f26ahr 2974 8 the the DT cord-028721-x6f26ahr 2974 9 presence presence NN cord-028721-x6f26ahr 2974 10 of of IN cord-028721-x6f26ahr 2974 11 spontaneous spontaneous JJ cord-028721-x6f26ahr 2974 12 pulses pulse NNS cord-028721-x6f26ahr 2974 13 of of IN cord-028721-x6f26ahr 2974 14 LH LH NNP cord-028721-x6f26ahr 2974 15 , , , cord-028721-x6f26ahr 2974 16 FSH fsh NN cord-028721-x6f26ahr 2974 17 , , , cord-028721-x6f26ahr 2974 18 and and CC cord-028721-x6f26ahr 2974 19 testosterone testosterone NN cord-028721-x6f26ahr 2974 20 during during IN cord-028721-x6f26ahr 2974 21 a a DT cord-028721-x6f26ahr 2974 22 24-hour 24-hour JJ cord-028721-x6f26ahr 2974 23 period period NN cord-028721-x6f26ahr 2974 24 . . . cord-028721-x6f26ahr 2975 1 Complete complete JJ cord-028721-x6f26ahr 2975 2 absence absence NN cord-028721-x6f26ahr 2975 3 is be VBZ cord-028721-x6f26ahr 2975 4 diagnosed diagnose VBN cord-028721-x6f26ahr 2975 5 by by IN cord-028721-x6f26ahr 2975 6 the the DT cord-028721-x6f26ahr 2975 7 absence absence NN cord-028721-x6f26ahr 2975 8 of of IN cord-028721-x6f26ahr 2975 9 spontaneous spontaneous JJ cord-028721-x6f26ahr 2975 10 pulses pulse NNS cord-028721-x6f26ahr 2975 11 of of IN cord-028721-x6f26ahr 2975 12 LH LH NNP cord-028721-x6f26ahr 2975 13 , , , cord-028721-x6f26ahr 2975 14 FSH fsh NN cord-028721-x6f26ahr 2975 15 , , , cord-028721-x6f26ahr 2975 16 and and CC cord-028721-x6f26ahr 2975 17 testosterone testosterone NN cord-028721-x6f26ahr 2975 18 during during IN cord-028721-x6f26ahr 2975 19 a a DT cord-028721-x6f26ahr 2975 20 24-hour 24-hour JJ cord-028721-x6f26ahr 2975 21 period period NN cord-028721-x6f26ahr 2975 22 . . . cord-028721-x6f26ahr 2976 1 These these DT cord-028721-x6f26ahr 2976 2 patients patient NNS cord-028721-x6f26ahr 2976 3 show show VBP cord-028721-x6f26ahr 2976 4 an an DT cord-028721-x6f26ahr 2976 5 increase increase NN cord-028721-x6f26ahr 2976 6 in in IN cord-028721-x6f26ahr 2976 7 FSH fsh NN cord-028721-x6f26ahr 2976 8 only only RB cord-028721-x6f26ahr 2976 9 after after IN cord-028721-x6f26ahr 2976 10 GnRH GnRH NNP cord-028721-x6f26ahr 2976 11 administration administration NN cord-028721-x6f26ahr 2976 12 . . . cord-028721-x6f26ahr 2977 1 1262 1262 CD cord-028721-x6f26ahr 2977 2 Testes testis NNS cord-028721-x6f26ahr 2977 3 are be VBP cord-028721-x6f26ahr 2977 4 histologically histologically RB cord-028721-x6f26ahr 2977 5 infantile infantile JJ cord-028721-x6f26ahr 2977 6 ; ; : cord-028721-x6f26ahr 2977 7 the the DT cord-028721-x6f26ahr 2977 8 tubules tubule NNS cord-028721-x6f26ahr 2977 9 have have VBP cord-028721-x6f26ahr 2977 10 a a DT cord-028721-x6f26ahr 2977 11 small small JJ cord-028721-x6f26ahr 2977 12 diameter diameter NN cord-028721-x6f26ahr 2977 13 , , , cord-028721-x6f26ahr 2977 14 lack lack JJ cord-028721-x6f26ahr 2977 15 lumina lumina NNP cord-028721-x6f26ahr 2977 16 , , , cord-028721-x6f26ahr 2977 17 and and CC cord-028721-x6f26ahr 2977 18 contain contain VBP cord-028721-x6f26ahr 2977 19 immature immature JJ cord-028721-x6f26ahr 2977 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 2977 21 cells cell NNS cord-028721-x6f26ahr 2977 22 and and CC cord-028721-x6f26ahr 2977 23 isolated isolate VBN cord-028721-x6f26ahr 2977 24 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 2977 25 . . . cord-028721-x6f26ahr 2978 1 1263 1263 CD cord-028721-x6f26ahr 2979 1 The the DT cord-028721-x6f26ahr 2979 2 interstitium interstitium NN cord-028721-x6f26ahr 2979 3 is be VBZ cord-028721-x6f26ahr 2979 4 wide wide JJ cord-028721-x6f26ahr 2979 5 and and CC cord-028721-x6f26ahr 2979 6 consists consist VBZ cord-028721-x6f26ahr 2979 7 of of IN cord-028721-x6f26ahr 2979 8 acellular acellular JJ cord-028721-x6f26ahr 2979 9 connective connective JJ cord-028721-x6f26ahr 2979 10 tissue tissue NN cord-028721-x6f26ahr 2979 11 with with IN cord-028721-x6f26ahr 2979 12 no no DT cord-028721-x6f26ahr 2979 13 recognizable recognizable JJ cord-028721-x6f26ahr 2979 14 Leydig Leydig NNP cord-028721-x6f26ahr 2979 15 cell cell NN cord-028721-x6f26ahr 2979 16 precursors precursor NNS cord-028721-x6f26ahr 2979 17 ( ( -LRB- cord-028721-x6f26ahr 2979 18 Fig fig NN cord-028721-x6f26ahr 2979 19 . . . cord-028721-x6f26ahr 2979 20 _SP cord-028721-x6f26ahr 2980 1 12 12 CD cord-028721-x6f26ahr 2980 2 - - SYM cord-028721-x6f26ahr 2980 3 137 137 CD cord-028721-x6f26ahr 2980 4 ) ) -RRB- cord-028721-x6f26ahr 2980 5 . . . cord-028721-x6f26ahr 2981 1 1264 1264 CD cord-028721-x6f26ahr 2982 1 Autopsy autopsy JJ cord-028721-x6f26ahr 2982 2 studies study NNS cord-028721-x6f26ahr 2982 3 in in IN cord-028721-x6f26ahr 2982 4 patients patient NNS cord-028721-x6f26ahr 2982 5 with with IN cord-028721-x6f26ahr 2982 6 anosmia anosmia NN cord-028721-x6f26ahr 2982 7 and and CC cord-028721-x6f26ahr 2982 8 hypogonadism hypogonadism NNS cord-028721-x6f26ahr 2982 9 reveal reveal VBP cord-028721-x6f26ahr 2982 10 agenesis agenesis NN cord-028721-x6f26ahr 2982 11 of of IN cord-028721-x6f26ahr 2982 12 the the DT cord-028721-x6f26ahr 2982 13 olfactory olfactory JJ cord-028721-x6f26ahr 2982 14 bulbs bulb NNS cord-028721-x6f26ahr 2982 15 that that WDT cord-028721-x6f26ahr 2982 16 may may MD cord-028721-x6f26ahr 2982 17 be be VB cord-028721-x6f26ahr 2982 18 partial partial JJ cord-028721-x6f26ahr 2982 19 or or CC cord-028721-x6f26ahr 2982 20 complete complete JJ cord-028721-x6f26ahr 2982 21 and and CC cord-028721-x6f26ahr 2982 22 unilateral unilateral JJ cord-028721-x6f26ahr 2982 23 or or CC cord-028721-x6f26ahr 2982 24 bilateral bilateral JJ cord-028721-x6f26ahr 2982 25 , , , cord-028721-x6f26ahr 2982 26 together together RB cord-028721-x6f26ahr 2982 27 with with IN cord-028721-x6f26ahr 2982 28 an an DT cord-028721-x6f26ahr 2982 29 apparently apparently RB cord-028721-x6f26ahr 2982 30 normal normal JJ cord-028721-x6f26ahr 2982 31 hypophysis hypophysis NN cord-028721-x6f26ahr 2982 32 and and CC cord-028721-x6f26ahr 2982 33 normal normal JJ cord-028721-x6f26ahr 2982 34 or or CC cord-028721-x6f26ahr 2982 35 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 2982 36 hypothalamus hypothalamus NN cord-028721-x6f26ahr 2982 37 . . . cord-028721-x6f26ahr 2983 1 This this DT cord-028721-x6f26ahr 2983 2 syndrome syndrome NN cord-028721-x6f26ahr 2983 3 is be VBZ cord-028721-x6f26ahr 2983 4 the the DT cord-028721-x6f26ahr 2983 5 least least JJS cord-028721-x6f26ahr 2983 6 severe severe JJ cord-028721-x6f26ahr 2983 7 form form NN cord-028721-x6f26ahr 2983 8 of of IN cord-028721-x6f26ahr 2983 9 holoprosencephaly holoprosencephaly NN cord-028721-x6f26ahr 2983 10 - - HYPH cord-028721-x6f26ahr 2983 11 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 2983 12 complex complex NN cord-028721-x6f26ahr 2983 13 , , , cord-028721-x6f26ahr 2983 14 a a DT cord-028721-x6f26ahr 2983 15 spectrum spectrum NN cord-028721-x6f26ahr 2983 16 of of IN cord-028721-x6f26ahr 2983 17 developmental developmental JJ cord-028721-x6f26ahr 2983 18 anomalies anomaly NNS cord-028721-x6f26ahr 2983 19 associated associate VBN cord-028721-x6f26ahr 2983 20 with with IN cord-028721-x6f26ahr 2983 21 impaired impaired JJ cord-028721-x6f26ahr 2983 22 midline midline JJ cord-028721-x6f26ahr 2983 23 cleavage cleavage NN cord-028721-x6f26ahr 2983 24 of of IN cord-028721-x6f26ahr 2983 25 the the DT cord-028721-x6f26ahr 2983 26 embryonic embryonic JJ cord-028721-x6f26ahr 2983 27 forebrain forebrain NN cord-028721-x6f26ahr 2983 28 , , , cord-028721-x6f26ahr 2983 29 aplasia aplasia NNP cord-028721-x6f26ahr 2983 30 of of IN cord-028721-x6f26ahr 2983 31 the the DT cord-028721-x6f26ahr 2983 32 olfactory olfactory JJ cord-028721-x6f26ahr 2983 33 bulbs bulb NNS cord-028721-x6f26ahr 2983 34 and and CC cord-028721-x6f26ahr 2983 35 tracts tract NNS cord-028721-x6f26ahr 2983 36 , , , cord-028721-x6f26ahr 2983 37 and and CC cord-028721-x6f26ahr 2983 38 midline midline JJ cord-028721-x6f26ahr 2983 39 dysplasia dysplasia NN cord-028721-x6f26ahr 2983 40 of of IN cord-028721-x6f26ahr 2983 41 the the DT cord-028721-x6f26ahr 2983 42 face face NN cord-028721-x6f26ahr 2983 43 . . . cord-028721-x6f26ahr 2984 1 Testicular testicular JJ cord-028721-x6f26ahr 2984 2 seminoma seminoma NN cord-028721-x6f26ahr 2984 3 has have VBZ cord-028721-x6f26ahr 2984 4 been be VBN cord-028721-x6f26ahr 2984 5 reported report VBN cord-028721-x6f26ahr 2984 6 in in IN cord-028721-x6f26ahr 2984 7 a a DT cord-028721-x6f26ahr 2984 8 patient patient NN cord-028721-x6f26ahr 2984 9 with with IN cord-028721-x6f26ahr 2984 10 anosmia anosmia NN cord-028721-x6f26ahr 2984 11 with with IN cord-028721-x6f26ahr 2984 12 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 2984 13 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 2984 14 . . . cord-028721-x6f26ahr 2985 1 1265 1265 CD cord-028721-x6f26ahr 2986 1 This this DT cord-028721-x6f26ahr 2986 2 rare rare JJ cord-028721-x6f26ahr 2986 3 syndrome syndrome NN cord-028721-x6f26ahr 2986 4 is be VBZ cord-028721-x6f26ahr 2986 5 characterized characterize VBN cord-028721-x6f26ahr 2986 6 by by IN cord-028721-x6f26ahr 2986 7 azoospermia azoospermia NN cord-028721-x6f26ahr 2986 8 or or CC cord-028721-x6f26ahr 2986 9 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 2986 10 in in IN cord-028721-x6f26ahr 2986 11 normally normally RB cord-028721-x6f26ahr 2986 12 virilized virilize VBN cord-028721-x6f26ahr 2986 13 patients patient NNS cord-028721-x6f26ahr 2986 14 with with IN cord-028721-x6f26ahr 2986 15 normal normal JJ cord-028721-x6f26ahr 2986 16 sexual sexual JJ cord-028721-x6f26ahr 2986 17 potency potency NN cord-028721-x6f26ahr 2986 18 . . . cord-028721-x6f26ahr 2987 1 Serum serum NN cord-028721-x6f26ahr 2987 2 levels level NNS cord-028721-x6f26ahr 2987 3 of of IN cord-028721-x6f26ahr 2987 4 LH lh NN cord-028721-x6f26ahr 2987 5 and and CC cord-028721-x6f26ahr 2987 6 testosterone testosterone NN cord-028721-x6f26ahr 2987 7 are be VBP cord-028721-x6f26ahr 2987 8 normal normal JJ cord-028721-x6f26ahr 2987 9 , , , cord-028721-x6f26ahr 2987 10 but but CC cord-028721-x6f26ahr 2987 11 FSH fsh NN cord-028721-x6f26ahr 2987 12 levels level NNS cord-028721-x6f26ahr 2987 13 are be VBP cord-028721-x6f26ahr 2987 14 very very RB cord-028721-x6f26ahr 2987 15 low low JJ cord-028721-x6f26ahr 2987 16 or or CC cord-028721-x6f26ahr 2987 17 undetectable undetectable JJ cord-028721-x6f26ahr 2987 18 . . . cord-028721-x6f26ahr 2988 1 The the DT cord-028721-x6f26ahr 2988 2 clomiphene clomiphene NNP cord-028721-x6f26ahr 2988 3 stimulation stimulation NN cord-028721-x6f26ahr 2988 4 test test NN cord-028721-x6f26ahr 2988 5 gives give VBZ cord-028721-x6f26ahr 2988 6 variable variable JJ cord-028721-x6f26ahr 2988 7 results result NNS cord-028721-x6f26ahr 2988 8 . . . cord-028721-x6f26ahr 2989 1 The the DT cord-028721-x6f26ahr 2989 2 GnRH GnRH NNP cord-028721-x6f26ahr 2989 3 test test NN cord-028721-x6f26ahr 2989 4 induces induce VBZ cord-028721-x6f26ahr 2989 5 a a DT cord-028721-x6f26ahr 2989 6 normal normal JJ cord-028721-x6f26ahr 2989 7 response response NN cord-028721-x6f26ahr 2989 8 only only RB cord-028721-x6f26ahr 2989 9 of of IN cord-028721-x6f26ahr 2989 10 LH LH NNP cord-028721-x6f26ahr 2989 11 . . . cord-028721-x6f26ahr 2990 1 Mutations mutation NNS cord-028721-x6f26ahr 2990 2 in in IN cord-028721-x6f26ahr 2990 3 the the DT cord-028721-x6f26ahr 2990 4 FSH FSH NNP cord-028721-x6f26ahr 2990 5 - - HYPH cord-028721-x6f26ahr 2990 6 β β NN cord-028721-x6f26ahr 2990 7 gene gene NN cord-028721-x6f26ahr 2990 8 are be VBP cord-028721-x6f26ahr 2990 9 exceptional exceptional JJ cord-028721-x6f26ahr 2990 10 . . . cord-028721-x6f26ahr 2991 1 1266 1266 CD cord-028721-x6f26ahr 2992 1 , , , cord-028721-x6f26ahr 2992 2 1267 1267 CD cord-028721-x6f26ahr 2992 3 Testicular Testicular NNP cord-028721-x6f26ahr 2992 4 biopsy biopsy NN cord-028721-x6f26ahr 2992 5 shows show VBZ cord-028721-x6f26ahr 2992 6 maturation maturation NN cord-028721-x6f26ahr 2992 7 arrest arrest NN cord-028721-x6f26ahr 2992 8 at at IN cord-028721-x6f26ahr 2992 9 the the DT cord-028721-x6f26ahr 2992 10 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 2992 11 level level NN cord-028721-x6f26ahr 2992 12 , , , cord-028721-x6f26ahr 2992 13 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 2992 14 , , , cord-028721-x6f26ahr 2992 15 or or CC cord-028721-x6f26ahr 2992 16 partial partial JJ cord-028721-x6f26ahr 2992 17 Sertoli sertoli JJ cord-028721-x6f26ahr 2992 18 cell cell NN cord-028721-x6f26ahr 2992 19 - - HYPH cord-028721-x6f26ahr 2992 20 only only RB cord-028721-x6f26ahr 2992 21 pattern pattern NN cord-028721-x6f26ahr 2992 22 . . . cord-028721-x6f26ahr 2993 1 1268 1268 CD cord-028721-x6f26ahr 2994 1 Gonadotropin gonadotropin JJ cord-028721-x6f26ahr 2994 2 treatment treatment NN cord-028721-x6f26ahr 2994 3 increases increase VBZ cord-028721-x6f26ahr 2994 4 spermatozoal spermatozoal NNP cord-028721-x6f26ahr 2994 5 numbers number NNS cord-028721-x6f26ahr 2994 6 in in IN cord-028721-x6f26ahr 2994 7 most most JJS cord-028721-x6f26ahr 2994 8 cases case NNS cord-028721-x6f26ahr 2994 9 , , , cord-028721-x6f26ahr 2994 10 and and CC cord-028721-x6f26ahr 2994 11 fertility fertility NN cord-028721-x6f26ahr 2994 12 may may MD cord-028721-x6f26ahr 2994 13 be be VB cord-028721-x6f26ahr 2994 14 induced induce VBN cord-028721-x6f26ahr 2994 15 . . . cord-028721-x6f26ahr 2995 1 Isolated isolated JJ cord-028721-x6f26ahr 2995 2 LH LH NNP cord-028721-x6f26ahr 2995 3 defi defi NNP cord-028721-x6f26ahr 2995 4 ciency ciency NNP cord-028721-x6f26ahr 2995 5 , , , cord-028721-x6f26ahr 2995 6 also also RB cord-028721-x6f26ahr 2995 7 known know VBN cord-028721-x6f26ahr 2995 8 as as IN cord-028721-x6f26ahr 2995 9 Pasqualini Pasqualini NNP cord-028721-x6f26ahr 2995 10 's 's POS cord-028721-x6f26ahr 2995 11 or or CC cord-028721-x6f26ahr 2995 12 fertile fertile JJ cord-028721-x6f26ahr 2995 13 eunuch eunuch NN cord-028721-x6f26ahr 2995 14 syndrome syndrome NN cord-028721-x6f26ahr 2995 15 , , , cord-028721-x6f26ahr 2995 16 1269 1269 CD cord-028721-x6f26ahr 2995 17 , , , cord-028721-x6f26ahr 2995 18 1270 1270 CD cord-028721-x6f26ahr 2995 19 is be VBZ cord-028721-x6f26ahr 2995 20 characterized characterize VBN cord-028721-x6f26ahr 2995 21 by by IN cord-028721-x6f26ahr 2995 22 hypogonadism hypogonadism NN cord-028721-x6f26ahr 2995 23 secondary secondary JJ cord-028721-x6f26ahr 2995 24 to to IN cord-028721-x6f26ahr 2995 25 LH LH NNP cord-028721-x6f26ahr 2995 26 defi defi NNP cord-028721-x6f26ahr 2995 27 cit cit NNP cord-028721-x6f26ahr 2995 28 with with IN cord-028721-x6f26ahr 2995 29 preservation preservation NN cord-028721-x6f26ahr 2995 30 of of IN cord-028721-x6f26ahr 2995 31 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 2995 32 . . . cord-028721-x6f26ahr 2996 1 Patients patient NNS cord-028721-x6f26ahr 2996 2 have have VBP cord-028721-x6f26ahr 2996 3 eunuchoid eunuchoid JJ cord-028721-x6f26ahr 2996 4 habitus habitus FW cord-028721-x6f26ahr 2996 5 , , , cord-028721-x6f26ahr 2996 6 small small JJ cord-028721-x6f26ahr 2996 7 testes testis NNS cord-028721-x6f26ahr 2996 8 , , , cord-028721-x6f26ahr 2996 9 decreased decrease VBD cord-028721-x6f26ahr 2996 10 libido libido NN cord-028721-x6f26ahr 2996 11 , , , cord-028721-x6f26ahr 2996 12 female female JJ cord-028721-x6f26ahr 2996 13 distribution distribution NN cord-028721-x6f26ahr 2996 14 of of IN cord-028721-x6f26ahr 2996 15 pubic pubic NN cord-028721-x6f26ahr 2996 16 hair hair NN cord-028721-x6f26ahr 2996 17 , , , cord-028721-x6f26ahr 2996 18 and and CC cord-028721-x6f26ahr 2996 19 a a DT cord-028721-x6f26ahr 2996 20 high high RB cord-028721-x6f26ahr 2996 21 - - HYPH cord-028721-x6f26ahr 2996 22 pitched pitch VBN cord-028721-x6f26ahr 2996 23 voice voice NN cord-028721-x6f26ahr 2996 24 . . . cord-028721-x6f26ahr 2997 1 Other other JJ cord-028721-x6f26ahr 2997 2 frequent frequent JJ cord-028721-x6f26ahr 2997 3 fi fi NN cord-028721-x6f26ahr 2997 4 ndings nding NNS cord-028721-x6f26ahr 2997 5 include include VBP cord-028721-x6f26ahr 2997 6 gynecomastia gynecomastia NN cord-028721-x6f26ahr 2997 7 , , , cord-028721-x6f26ahr 2997 8 anosmia anosmia NN cord-028721-x6f26ahr 2997 9 , , , cord-028721-x6f26ahr 2997 10 ocular ocular JJ cord-028721-x6f26ahr 2997 11 lesions lesion NNS cord-028721-x6f26ahr 2997 12 , , , cord-028721-x6f26ahr 2997 13 and and CC cord-028721-x6f26ahr 2997 14 pituitary pituitary JJ cord-028721-x6f26ahr 2997 15 tumor tumor NN cord-028721-x6f26ahr 2997 16 . . . cord-028721-x6f26ahr 2998 1 1271 1271 CD cord-028721-x6f26ahr 2998 2 FSH fsh NN cord-028721-x6f26ahr 2998 3 level level NN cord-028721-x6f26ahr 2998 4 is be VBZ cord-028721-x6f26ahr 2998 5 normal normal JJ cord-028721-x6f26ahr 2998 6 , , , cord-028721-x6f26ahr 2998 7 but but CC cord-028721-x6f26ahr 2998 8 LH lh NN cord-028721-x6f26ahr 2998 9 and and CC cord-028721-x6f26ahr 2998 10 testosterone testosterone NN cord-028721-x6f26ahr 2998 11 levels level NNS cord-028721-x6f26ahr 2998 12 are be VBP cord-028721-x6f26ahr 2998 13 very very RB cord-028721-x6f26ahr 2998 14 low low JJ cord-028721-x6f26ahr 2998 15 . . . cord-028721-x6f26ahr 2999 1 Mutations mutation NNS cord-028721-x6f26ahr 2999 2 in in IN cord-028721-x6f26ahr 2999 3 the the DT cord-028721-x6f26ahr 2999 4 LH LH NNP cord-028721-x6f26ahr 2999 5 - - HYPH cord-028721-x6f26ahr 2999 6 β β NNP cord-028721-x6f26ahr 2999 7 subunit subunit NN cord-028721-x6f26ahr 2999 8 gene gene NN cord-028721-x6f26ahr 2999 9 1272 1272 CD cord-028721-x6f26ahr 2999 10 and and CC cord-028721-x6f26ahr 2999 11 the the DT cord-028721-x6f26ahr 2999 12 GnRH GnRH NNP cord-028721-x6f26ahr 2999 13 receptor receptor NN cord-028721-x6f26ahr 2999 14 have have VBP cord-028721-x6f26ahr 2999 15 been be VBN cord-028721-x6f26ahr 2999 16 reported report VBN cord-028721-x6f26ahr 2999 17 . . . cord-028721-x6f26ahr 3000 1 1273 1273 CD cord-028721-x6f26ahr 3000 2 _SP cord-028721-x6f26ahr 3001 1 The the DT cord-028721-x6f26ahr 3001 2 clomiphene clomiphene NNP cord-028721-x6f26ahr 3001 3 test test NN cord-028721-x6f26ahr 3001 4 is be VBZ cord-028721-x6f26ahr 3001 5 usually usually RB cord-028721-x6f26ahr 3001 6 negative negative JJ cord-028721-x6f26ahr 3001 7 , , , cord-028721-x6f26ahr 3001 8 and and CC cord-028721-x6f26ahr 3001 9 GnRH gnrh JJ cord-028721-x6f26ahr 3001 10 stimulation stimulation NN cord-028721-x6f26ahr 3001 11 increases increase VBZ cord-028721-x6f26ahr 3001 12 LH LH NNP cord-028721-x6f26ahr 3001 13 and and CC cord-028721-x6f26ahr 3001 14 , , , cord-028721-x6f26ahr 3001 15 to to IN cord-028721-x6f26ahr 3001 16 a a DT cord-028721-x6f26ahr 3001 17 lesser less JJR cord-028721-x6f26ahr 3001 18 degree degree NN cord-028721-x6f26ahr 3001 19 , , , cord-028721-x6f26ahr 3001 20 FSH fsh NN cord-028721-x6f26ahr 3001 21 . . . cord-028721-x6f26ahr 3002 1 Testicular testicular JJ cord-028721-x6f26ahr 3002 2 biopsy biopsy NN cord-028721-x6f26ahr 3002 3 shows show VBZ cord-028721-x6f26ahr 3002 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 3002 5 tubules tubule NNS cord-028721-x6f26ahr 3002 6 with with IN cord-028721-x6f26ahr 3002 7 normal normal JJ cord-028721-x6f26ahr 3002 8 or or CC cord-028721-x6f26ahr 3002 9 slightly slightly RB cord-028721-x6f26ahr 3002 10 decreased decreased JJ cord-028721-x6f26ahr 3002 11 diameters diameter NNS cord-028721-x6f26ahr 3002 12 and and CC cord-028721-x6f26ahr 3002 13 complete complete JJ cord-028721-x6f26ahr 3002 14 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3002 15 ; ; : cord-028721-x6f26ahr 3002 16 however however RB cord-028721-x6f26ahr 3002 17 , , , cord-028721-x6f26ahr 3002 18 the the DT cord-028721-x6f26ahr 3002 19 number number NN cord-028721-x6f26ahr 3002 20 of of IN cord-028721-x6f26ahr 3002 21 all all DT cord-028721-x6f26ahr 3002 22 germ germ NN cord-028721-x6f26ahr 3002 23 cell cell NN cord-028721-x6f26ahr 3002 24 types type NNS cord-028721-x6f26ahr 3002 25 is be VBZ cord-028721-x6f26ahr 3002 26 below below IN cord-028721-x6f26ahr 3002 27 normal normal JJ cord-028721-x6f26ahr 3002 28 . . . cord-028721-x6f26ahr 3003 1 Leydig leydig NN cord-028721-x6f26ahr 3003 2 cells cell NNS cord-028721-x6f26ahr 3003 3 are be VBP cord-028721-x6f26ahr 3003 4 rare rare JJ cord-028721-x6f26ahr 3003 5 or or CC cord-028721-x6f26ahr 3003 6 absent absent JJ cord-028721-x6f26ahr 3004 1 ( ( -LRB- cord-028721-x6f26ahr 3004 2 Fig Fig NNP cord-028721-x6f26ahr 3004 3 . . . cord-028721-x6f26ahr 3004 4 12 12 CD cord-028721-x6f26ahr 3004 5 - - SYM cord-028721-x6f26ahr 3004 6 138 138 CD cord-028721-x6f26ahr 3004 7 ) ) -RRB- cord-028721-x6f26ahr 3004 8 . . . cord-028721-x6f26ahr 3005 1 Maintenance maintenance NN cord-028721-x6f26ahr 3005 2 of of IN cord-028721-x6f26ahr 3005 3 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3005 4 in in IN cord-028721-x6f26ahr 3005 5 the the DT cord-028721-x6f26ahr 3005 6 absence absence NN cord-028721-x6f26ahr 3005 7 of of IN cord-028721-x6f26ahr 3005 8 Leydig leydig NN cord-028721-x6f26ahr 3005 9 cells cell NNS cord-028721-x6f26ahr 3005 10 and and CC cord-028721-x6f26ahr 3005 11 serum serum NN cord-028721-x6f26ahr 3005 12 testosterone testosterone NN cord-028721-x6f26ahr 3005 13 can can MD cord-028721-x6f26ahr 3005 14 only only RB cord-028721-x6f26ahr 3005 15 be be VB cord-028721-x6f26ahr 3005 16 explained explain VBN cord-028721-x6f26ahr 3005 17 by by IN cord-028721-x6f26ahr 3005 18 assuming assume VBG cord-028721-x6f26ahr 3005 19 the the DT cord-028721-x6f26ahr 3005 20 occurrence occurrence NN cord-028721-x6f26ahr 3005 21 of of IN cord-028721-x6f26ahr 3005 22 testosterone testosterone NN cord-028721-x6f26ahr 3005 23 secretion secretion NN cord-028721-x6f26ahr 3005 24 suffi suffi NNP cord-028721-x6f26ahr 3005 25 cient cient NNP cord-028721-x6f26ahr 3005 26 for for IN cord-028721-x6f26ahr 3005 27 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3005 28 but but CC cord-028721-x6f26ahr 3005 29 not not RB cord-028721-x6f26ahr 3005 30 to to TO cord-028721-x6f26ahr 3005 31 be be VB cord-028721-x6f26ahr 3005 32 detectable detectable JJ cord-028721-x6f26ahr 3005 33 in in IN cord-028721-x6f26ahr 3005 34 the the DT cord-028721-x6f26ahr 3005 35 blood blood NN cord-028721-x6f26ahr 3005 36 . . . cord-028721-x6f26ahr 3006 1 In in IN cord-028721-x6f26ahr 3006 2 addition addition NN cord-028721-x6f26ahr 3006 3 to to TO cord-028721-x6f26ahr 3006 4 adequate adequate VB cord-028721-x6f26ahr 3006 5 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 3006 6 function function NN cord-028721-x6f26ahr 3006 7 , , , cord-028721-x6f26ahr 3006 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3006 9 requires require VBZ cord-028721-x6f26ahr 3006 10 that that IN cord-028721-x6f26ahr 3006 11 FSH fsh NN cord-028721-x6f26ahr 3006 12 and and CC cord-028721-x6f26ahr 3006 13 LH LH NNP cord-028721-x6f26ahr 3006 14 are be VBP cord-028721-x6f26ahr 3006 15 biologically biologically RB cord-028721-x6f26ahr 3006 16 active active JJ cord-028721-x6f26ahr 3006 17 . . . cord-028721-x6f26ahr 3007 1 LH LH NNP cord-028721-x6f26ahr 3007 2 is be VBZ cord-028721-x6f26ahr 3007 3 a a DT cord-028721-x6f26ahr 3007 4 heterodimer heterodimer NN cord-028721-x6f26ahr 3007 5 , , , cord-028721-x6f26ahr 3007 6 composed compose VBN cord-028721-x6f26ahr 3007 7 of of IN cord-028721-x6f26ahr 3007 8 two two CD cord-028721-x6f26ahr 3007 9 subunits subunit NNS cord-028721-x6f26ahr 3007 10 : : : cord-028721-x6f26ahr 3007 11 α α NN cord-028721-x6f26ahr 3007 12 ( ( -LRB- cord-028721-x6f26ahr 3007 13 common common JJ cord-028721-x6f26ahr 3007 14 to to IN cord-028721-x6f26ahr 3007 15 FSH FSH NNP cord-028721-x6f26ahr 3007 16 and and CC cord-028721-x6f26ahr 3007 17 LH LH NNP cord-028721-x6f26ahr 3007 18 ) ) -RRB- cord-028721-x6f26ahr 3007 19 and and CC cord-028721-x6f26ahr 3007 20 β β FW cord-028721-x6f26ahr 3007 21 ( ( -LRB- cord-028721-x6f26ahr 3007 22 specifi specifi NNP cord-028721-x6f26ahr 3007 23 c c NN cord-028721-x6f26ahr 3007 24 for for IN cord-028721-x6f26ahr 3007 25 LH LH NNP cord-028721-x6f26ahr 3007 26 ) ) -RRB- cord-028721-x6f26ahr 3007 27 . . . cord-028721-x6f26ahr 3008 1 The the DT cord-028721-x6f26ahr 3008 2 genes gene NNS cord-028721-x6f26ahr 3008 3 for for IN cord-028721-x6f26ahr 3008 4 the the DT cord-028721-x6f26ahr 3008 5 β β NNP cord-028721-x6f26ahr 3008 6 subunit subunit NN cord-028721-x6f26ahr 3008 7 are be VBP cord-028721-x6f26ahr 3008 8 on on IN cord-028721-x6f26ahr 3008 9 19q13.32 19q13.32 CD cord-028721-x6f26ahr 3008 10 . . . cord-028721-x6f26ahr 3009 1 If if IN cord-028721-x6f26ahr 3009 2 both both DT cord-028721-x6f26ahr 3009 3 alleles allele NNS cord-028721-x6f26ahr 3009 4 are be VBP cord-028721-x6f26ahr 3009 5 mutated mutate VBN cord-028721-x6f26ahr 3009 6 for for IN cord-028721-x6f26ahr 3009 7 this this DT cord-028721-x6f26ahr 3009 8 subunit subunit NN cord-028721-x6f26ahr 3009 9 , , , cord-028721-x6f26ahr 3009 10 the the DT cord-028721-x6f26ahr 3009 11 LH LH NNP cord-028721-x6f26ahr 3009 12 produced produce VBD cord-028721-x6f26ahr 3009 13 in in IN cord-028721-x6f26ahr 3009 14 biologically biologically RB cord-028721-x6f26ahr 3009 15 inactive inactive JJ cord-028721-x6f26ahr 3009 16 although although IN cord-028721-x6f26ahr 3009 17 it -PRON- PRP cord-028721-x6f26ahr 3009 18 may may MD cord-028721-x6f26ahr 3009 19 be be VB cord-028721-x6f26ahr 3009 20 detectable detectable JJ cord-028721-x6f26ahr 3009 21 in in IN cord-028721-x6f26ahr 3009 22 standard standard JJ cord-028721-x6f26ahr 3009 23 hormone hormone NN cord-028721-x6f26ahr 3009 24 assay assay NN cord-028721-x6f26ahr 3009 25 . . . cord-028721-x6f26ahr 3010 1 Homozygous Homozygous NNP cord-028721-x6f26ahr 3010 2 patients patient NNS cord-028721-x6f26ahr 3010 3 have have VBP cord-028721-x6f26ahr 3010 4 elevated elevate VBN cord-028721-x6f26ahr 3010 5 serum serum NN cord-028721-x6f26ahr 3010 6 level level NN cord-028721-x6f26ahr 3010 7 of of IN cord-028721-x6f26ahr 3010 8 LH lh NN cord-028721-x6f26ahr 3010 9 and and CC cord-028721-x6f26ahr 3010 10 low low JJ cord-028721-x6f26ahr 3010 11 testosterone testosterone NN cord-028721-x6f26ahr 3010 12 levels level NNS cord-028721-x6f26ahr 3010 13 , , , cord-028721-x6f26ahr 3010 14 lack lack NN cord-028721-x6f26ahr 3010 15 of of IN cord-028721-x6f26ahr 3010 16 puberty puberty NN cord-028721-x6f26ahr 3010 17 , , , cord-028721-x6f26ahr 3010 18 and and CC cord-028721-x6f26ahr 3010 19 infantile infantile JJ cord-028721-x6f26ahr 3010 20 testes testis NNS cord-028721-x6f26ahr 3010 21 . . . cord-028721-x6f26ahr 3011 1 Heterozygous heterozygous JJ cord-028721-x6f26ahr 3011 2 patients patient NNS cord-028721-x6f26ahr 3011 3 are be VBP cord-028721-x6f26ahr 3011 4 only only RB cord-028721-x6f26ahr 3011 5 infertile infertile JJ cord-028721-x6f26ahr 3011 6 . . . cord-028721-x6f26ahr 3012 1 1274 1274 CD cord-028721-x6f26ahr 3012 2 Patients patient NNS cord-028721-x6f26ahr 3012 3 with with IN cord-028721-x6f26ahr 3012 4 mutation mutation NN cord-028721-x6f26ahr 3012 5 in in IN cord-028721-x6f26ahr 3012 6 the the DT cord-028721-x6f26ahr 3012 7 β β NNP cord-028721-x6f26ahr 3012 8 subunit subunit NN cord-028721-x6f26ahr 3012 9 of of IN cord-028721-x6f26ahr 3012 10 the the DT cord-028721-x6f26ahr 3012 11 FSH FSH NNP cord-028721-x6f26ahr 3012 12 gene gene NN cord-028721-x6f26ahr 3012 13 are be VBP cord-028721-x6f26ahr 3012 14 oligozoospermic oligozoospermic JJ cord-028721-x6f26ahr 3012 15 or or CC cord-028721-x6f26ahr 3012 16 azoospermic azoospermic NNP cord-028721-x6f26ahr 3012 17 . . . cord-028721-x6f26ahr 3013 1 1275 1275 CD cord-028721-x6f26ahr 3014 1 Activating activate VBG cord-028721-x6f26ahr 3014 2 and and CC cord-028721-x6f26ahr 3014 3 inactivating inactivate VBG cord-028721-x6f26ahr 3014 4 mutations mutation NNS cord-028721-x6f26ahr 3014 5 of of IN cord-028721-x6f26ahr 3014 6 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 3014 7 receptor receptor NN cord-028721-x6f26ahr 3014 8 genes gene NNS cord-028721-x6f26ahr 3014 9 have have VBP cord-028721-x6f26ahr 3014 10 been be VBN cord-028721-x6f26ahr 3014 11 reported report VBN cord-028721-x6f26ahr 3014 12 . . . cord-028721-x6f26ahr 3015 1 Activating activate VBG cord-028721-x6f26ahr 3015 2 mutation mutation NN cord-028721-x6f26ahr 3015 3 of of IN cord-028721-x6f26ahr 3015 4 the the DT cord-028721-x6f26ahr 3015 5 LH LH NNP cord-028721-x6f26ahr 3015 6 / / SYM cord-028721-x6f26ahr 3015 7 human human JJ cord-028721-x6f26ahr 3015 8 chorionic chorionic JJ cord-028721-x6f26ahr 3015 9 gonadotropin gonadotropin NN cord-028721-x6f26ahr 3015 10 receptor receptor NN cord-028721-x6f26ahr 3015 11 gene gene NN cord-028721-x6f26ahr 3015 12 causes cause VBZ cord-028721-x6f26ahr 3015 13 familial familial JJ cord-028721-x6f26ahr 3015 14 precocious precocious JJ cord-028721-x6f26ahr 3015 15 puberty puberty NN cord-028721-x6f26ahr 3015 16 ( ( -LRB- cord-028721-x6f26ahr 3015 17 see see VB cord-028721-x6f26ahr 3015 18 discussion discussion NN cord-028721-x6f26ahr 3015 19 on on IN cord-028721-x6f26ahr 3015 20 familial familial JJ cord-028721-x6f26ahr 3015 21 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 3015 22 , , , cord-028721-x6f26ahr 3015 23 below below RB cord-028721-x6f26ahr 3015 24 ) ) -RRB- cord-028721-x6f26ahr 3015 25 . . . cord-028721-x6f26ahr 3016 1 Inactivating inactivate VBG cord-028721-x6f26ahr 3016 2 mutation mutation NN cord-028721-x6f26ahr 3016 3 of of IN cord-028721-x6f26ahr 3016 4 this this DT cord-028721-x6f26ahr 3016 5 gene gene NN cord-028721-x6f26ahr 3016 6 causes cause VBZ cord-028721-x6f26ahr 3016 7 male male JJ cord-028721-x6f26ahr 3016 8 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 3016 9 ( ( -LRB- cord-028721-x6f26ahr 3016 10 see see VB cord-028721-x6f26ahr 3016 11 discussion discussion NN cord-028721-x6f26ahr 3016 12 on on IN cord-028721-x6f26ahr 3016 13 Leydig Leydig NNP cord-028721-x6f26ahr 3016 14 cell cell NN cord-028721-x6f26ahr 3016 15 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3016 16 in in IN cord-028721-x6f26ahr 3016 17 this this DT cord-028721-x6f26ahr 3016 18 chapter chapter NN cord-028721-x6f26ahr 3016 19 ) ) -RRB- cord-028721-x6f26ahr 3016 20 . . . cord-028721-x6f26ahr 3017 1 Inactivating inactivate VBG cord-028721-x6f26ahr 3017 2 mutation mutation NN cord-028721-x6f26ahr 3017 3 of of IN cord-028721-x6f26ahr 3017 4 the the DT cord-028721-x6f26ahr 3017 5 FSH FSH NNP cord-028721-x6f26ahr 3017 6 receptor receptor NN cord-028721-x6f26ahr 3017 7 gene gene NN cord-028721-x6f26ahr 3017 8 produces produce VBZ cord-028721-x6f26ahr 3017 9 only only RB cord-028721-x6f26ahr 3017 10 mild mild JJ cord-028721-x6f26ahr 3017 11 spermatogenetic spermatogenetic NN cord-028721-x6f26ahr 3017 12 lesions lesion NNS cord-028721-x6f26ahr 3017 13 , , , cord-028721-x6f26ahr 3017 14 emphasizing emphasize VBG cord-028721-x6f26ahr 3017 15 the the DT cord-028721-x6f26ahr 3017 16 relative relative JJ cord-028721-x6f26ahr 3017 17 value value NN cord-028721-x6f26ahr 3017 18 assumed assume VBN cord-028721-x6f26ahr 3017 19 for for IN cord-028721-x6f26ahr 3017 20 FSH fsh NN cord-028721-x6f26ahr 3017 21 in in IN cord-028721-x6f26ahr 3017 22 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3017 23 . . . cord-028721-x6f26ahr 3018 1 Activating activate VBG cord-028721-x6f26ahr 3018 2 muta muta NN cord-028721-x6f26ahr 3018 3 - - HYPH cord-028721-x6f26ahr 3018 4 tion tion NN cord-028721-x6f26ahr 3018 5 of of IN cord-028721-x6f26ahr 3018 6 this this DT cord-028721-x6f26ahr 3018 7 gene gene NN cord-028721-x6f26ahr 3018 8 gives give VBZ cord-028721-x6f26ahr 3018 9 rise rise NN cord-028721-x6f26ahr 3018 10 to to IN cord-028721-x6f26ahr 3018 11 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3018 12 even even RB cord-028721-x6f26ahr 3018 13 in in IN cord-028721-x6f26ahr 3018 14 the the DT cord-028721-x6f26ahr 3018 15 absence absence NN cord-028721-x6f26ahr 3018 16 of of IN cord-028721-x6f26ahr 3018 17 pituitary pituitary NN cord-028721-x6f26ahr 3018 18 function function NN cord-028721-x6f26ahr 3018 19 . . . cord-028721-x6f26ahr 3019 1 Patients patient NNS cord-028721-x6f26ahr 3019 2 with with IN cord-028721-x6f26ahr 3019 3 isolated isolated JJ cord-028721-x6f26ahr 3019 4 growth growth NN cord-028721-x6f26ahr 3019 5 hormone hormone NN cord-028721-x6f26ahr 3019 6 defi defi NNP cord-028721-x6f26ahr 3019 7 cit cit NNP cord-028721-x6f26ahr 3019 8 and and CC cord-028721-x6f26ahr 3019 9 those those DT cord-028721-x6f26ahr 3019 10 with with IN cord-028721-x6f26ahr 3019 11 resistance resistance NN cord-028721-x6f26ahr 3019 12 to to IN cord-028721-x6f26ahr 3019 13 growth growth NN cord-028721-x6f26ahr 3019 14 hormone hormone NN cord-028721-x6f26ahr 3019 15 action action NN cord-028721-x6f26ahr 3019 16 may may MD cord-028721-x6f26ahr 3019 17 have have VB cord-028721-x6f26ahr 3019 18 delayed delay VBN cord-028721-x6f26ahr 3019 19 puberty puberty NN cord-028721-x6f26ahr 3019 20 and and CC cord-028721-x6f26ahr 3019 21 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3019 22 hypogonadism hypogonadism NNS cord-028721-x6f26ahr 3019 23 . . . cord-028721-x6f26ahr 3020 1 1276 1276 CD cord-028721-x6f26ahr 3021 1 Some some DT cord-028721-x6f26ahr 3021 2 patients patient NNS cord-028721-x6f26ahr 3021 3 with with IN cord-028721-x6f26ahr 3021 4 spermatogenetic spermatogenetic NNP cord-028721-x6f26ahr 3021 5 maturation maturation NN cord-028721-x6f26ahr 3021 6 arrest arrest NN cord-028721-x6f26ahr 3021 7 or or CC cord-028721-x6f26ahr 3021 8 idiopathic idiopathic JJ cord-028721-x6f26ahr 3021 9 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3021 10 have have VBP cord-028721-x6f26ahr 3021 11 a a DT cord-028721-x6f26ahr 3021 12 relative relative JJ cord-028721-x6f26ahr 3021 13 defi defi NNP cord-028721-x6f26ahr 3021 14 cit cit NNP cord-028721-x6f26ahr 3021 15 of of IN cord-028721-x6f26ahr 3021 16 growth growth NN cord-028721-x6f26ahr 3021 17 hormone hormone NN cord-028721-x6f26ahr 3021 18 . . . cord-028721-x6f26ahr 3022 1 This this DT cord-028721-x6f26ahr 3022 2 hormone hormone NN cord-028721-x6f26ahr 3022 3 probably probably RB cord-028721-x6f26ahr 3022 4 acts act VBZ cord-028721-x6f26ahr 3022 5 on on IN cord-028721-x6f26ahr 3022 6 the the DT cord-028721-x6f26ahr 3022 7 testis testis NN cord-028721-x6f26ahr 3022 8 by by IN cord-028721-x6f26ahr 3022 9 stimulating stimulate VBG cord-028721-x6f26ahr 3022 10 local local JJ cord-028721-x6f26ahr 3022 11 secretion secretion NN cord-028721-x6f26ahr 3022 12 of of IN cord-028721-x6f26ahr 3022 13 insulin insulin NN cord-028721-x6f26ahr 3022 14 - - HYPH cord-028721-x6f26ahr 3022 15 like like JJ cord-028721-x6f26ahr 3022 16 growth growth NN cord-028721-x6f26ahr 3022 17 factor-1 factor-1 NNP cord-028721-x6f26ahr 3022 18 , , , cord-028721-x6f26ahr 3022 19 which which WDT cord-028721-x6f26ahr 3022 20 cooperates cooperate VBZ cord-028721-x6f26ahr 3022 21 with with IN cord-028721-x6f26ahr 3022 22 testosterone testosterone NN cord-028721-x6f26ahr 3022 23 . . . cord-028721-x6f26ahr 3023 1 Prader Prader NNP cord-028721-x6f26ahr 3023 2 - - HYPH cord-028721-x6f26ahr 3023 3 Willi Willi NNP cord-028721-x6f26ahr 3023 4 syndrome syndrome NN cord-028721-x6f26ahr 3023 5 is be VBZ cord-028721-x6f26ahr 3023 6 characterized characterize VBN cord-028721-x6f26ahr 3023 7 by by IN cord-028721-x6f26ahr 3023 8 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3023 9 , , , cord-028721-x6f26ahr 3023 10 obesity obesity NN cord-028721-x6f26ahr 3023 11 , , , cord-028721-x6f26ahr 3023 12 muscular muscular JJ cord-028721-x6f26ahr 3023 13 hypotonia hypotonia NNS cord-028721-x6f26ahr 3023 14 , , , cord-028721-x6f26ahr 3023 15 mental mental JJ cord-028721-x6f26ahr 3023 16 and and CC cord-028721-x6f26ahr 3023 17 physical physical JJ cord-028721-x6f26ahr 3023 18 retardation retardation NN cord-028721-x6f26ahr 3023 19 , , , cord-028721-x6f26ahr 3023 20 and and CC cord-028721-x6f26ahr 3023 21 acromicria acromicria NNP cord-028721-x6f26ahr 3023 22 . . . cord-028721-x6f26ahr 3024 1 1277 1277 CD cord-028721-x6f26ahr 3025 1 Other other JJ cord-028721-x6f26ahr 3025 2 frequent frequent JJ cord-028721-x6f26ahr 3025 3 fi fi NN cord-028721-x6f26ahr 3025 4 ndings nding NNS cord-028721-x6f26ahr 3025 5 include include VBP cord-028721-x6f26ahr 3025 6 strabismus strabismus NN cord-028721-x6f26ahr 3025 7 and and CC cord-028721-x6f26ahr 3025 8 non non JJ cord-028721-x6f26ahr 3025 9 - - JJ cord-028721-x6f26ahr 3025 10 insulin insulin JJ cord-028721-x6f26ahr 3025 11 - - HYPH cord-028721-x6f26ahr 3025 12 dependent dependent JJ cord-028721-x6f26ahr 3025 13 diabetes diabetes NN cord-028721-x6f26ahr 3025 14 mellitus mellitus NN cord-028721-x6f26ahr 3025 15 . . . cord-028721-x6f26ahr 3026 1 The the DT cord-028721-x6f26ahr 3026 2 incidence incidence NN cord-028721-x6f26ahr 3026 3 is be VBZ cord-028721-x6f26ahr 3026 4 estimated estimate VBN cord-028721-x6f26ahr 3026 5 at at IN cord-028721-x6f26ahr 3026 6 between between IN cord-028721-x6f26ahr 3026 7 1 1 CD cord-028721-x6f26ahr 3026 8 in in IN cord-028721-x6f26ahr 3026 9 12 12 CD cord-028721-x6f26ahr 3026 10 000 000 CD cord-028721-x6f26ahr 3026 11 and and CC cord-028721-x6f26ahr 3026 12 1 1 CD cord-028721-x6f26ahr 3026 13 in in IN cord-028721-x6f26ahr 3026 14 15 15 CD cord-028721-x6f26ahr 3026 15 000 000 CD cord-028721-x6f26ahr 3026 16 newborns newborn NNS cord-028721-x6f26ahr 3026 17 in in IN cord-028721-x6f26ahr 3026 18 25 25 CD cord-028721-x6f26ahr 3026 19 000 000 CD cord-028721-x6f26ahr 3026 20 live live JJ cord-028721-x6f26ahr 3026 21 births birth NNS cord-028721-x6f26ahr 3026 22 , , , cord-028721-x6f26ahr 3026 23 and and CC cord-028721-x6f26ahr 3026 24 is be VBZ cord-028721-x6f26ahr 3026 25 higher high JJR cord-028721-x6f26ahr 3026 26 in in IN cord-028721-x6f26ahr 3026 27 males male NNS cord-028721-x6f26ahr 3026 28 . . . cord-028721-x6f26ahr 3027 1 Patients patient NNS cord-028721-x6f26ahr 3027 2 have have VBP cord-028721-x6f26ahr 3027 3 low low JJ cord-028721-x6f26ahr 3027 4 serum serum NN cord-028721-x6f26ahr 3027 5 levels level NNS cord-028721-x6f26ahr 3027 6 of of IN cord-028721-x6f26ahr 3027 7 LH lh NN cord-028721-x6f26ahr 3027 8 , , , cord-028721-x6f26ahr 3027 9 testosterone testosterone NN cord-028721-x6f26ahr 3027 10 , , , cord-028721-x6f26ahr 3027 11 estradiol estradiol NN cord-028721-x6f26ahr 3027 12 , , , cord-028721-x6f26ahr 3027 13 and and CC cord-028721-x6f26ahr 3027 14 inhibin inhibin NNP cord-028721-x6f26ahr 3027 15 B B NNP cord-028721-x6f26ahr 3027 16 , , , cord-028721-x6f26ahr 3027 17 and and CC cord-028721-x6f26ahr 3027 18 high high JJ cord-028721-x6f26ahr 3027 19 levels level NNS cord-028721-x6f26ahr 3027 20 of of IN cord-028721-x6f26ahr 3027 21 FSH fsh NN cord-028721-x6f26ahr 3027 22 . . . cord-028721-x6f26ahr 3028 1 These these DT cord-028721-x6f26ahr 3028 2 hormonal hormonal JJ cord-028721-x6f26ahr 3028 3 fi fi NN cord-028721-x6f26ahr 3028 4 ndings nding NNS cord-028721-x6f26ahr 3028 5 suggest suggest VBP cord-028721-x6f26ahr 3028 6 the the DT cord-028721-x6f26ahr 3028 7 occurrence occurrence NN cord-028721-x6f26ahr 3028 8 of of IN cord-028721-x6f26ahr 3028 9 a a DT cord-028721-x6f26ahr 3028 10 mixed mixed JJ cord-028721-x6f26ahr 3028 11 form form NN cord-028721-x6f26ahr 3028 12 of of IN cord-028721-x6f26ahr 3028 13 central central JJ cord-028721-x6f26ahr 3028 14 ( ( -LRB- cord-028721-x6f26ahr 3028 15 low low JJ cord-028721-x6f26ahr 3028 16 LH LH NNP cord-028721-x6f26ahr 3028 17 ) ) -RRB- cord-028721-x6f26ahr 3028 18 and and CC cord-028721-x6f26ahr 3028 19 peripheral peripheral JJ cord-028721-x6f26ahr 3028 20 ( ( -LRB- cord-028721-x6f26ahr 3028 21 low low JJ cord-028721-x6f26ahr 3028 22 inhibin inhibin NN cord-028721-x6f26ahr 3028 23 B b NN cord-028721-x6f26ahr 3028 24 and and CC cord-028721-x6f26ahr 3028 25 high high JJ cord-028721-x6f26ahr 3028 26 FSH fsh NN cord-028721-x6f26ahr 3028 27 ) ) -RRB- cord-028721-x6f26ahr 3028 28 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3028 29 . . . cord-028721-x6f26ahr 3029 1 1278 1278 CD cord-028721-x6f26ahr 3030 1 The the DT cord-028721-x6f26ahr 3030 2 penis penis NN cord-028721-x6f26ahr 3030 3 and and CC cord-028721-x6f26ahr 3030 4 testes testis NNS cord-028721-x6f26ahr 3030 5 are be VBP cord-028721-x6f26ahr 3030 6 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 3030 7 , , , cord-028721-x6f26ahr 3030 8 and and CC cord-028721-x6f26ahr 3030 9 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3030 10 is be VBZ cord-028721-x6f26ahr 3030 11 present present JJ cord-028721-x6f26ahr 3030 12 in in IN cord-028721-x6f26ahr 3030 13 about about RB cord-028721-x6f26ahr 3030 14 70 70 CD cord-028721-x6f26ahr 3030 15 % % NN cord-028721-x6f26ahr 3030 16 of of IN cord-028721-x6f26ahr 3030 17 cases case NNS cord-028721-x6f26ahr 3030 18 ( ( -LRB- cord-028721-x6f26ahr 3030 19 bilateral bilateral JJ cord-028721-x6f26ahr 3030 20 in in IN cord-028721-x6f26ahr 3030 21 45 45 CD cord-028721-x6f26ahr 3030 22 % % NN cord-028721-x6f26ahr 3030 23 of of IN cord-028721-x6f26ahr 3030 24 cases case NNS cord-028721-x6f26ahr 3030 25 ) ) -RRB- cord-028721-x6f26ahr 3031 1 ( ( -LRB- cord-028721-x6f26ahr 3031 2 Fig Fig NNP cord-028721-x6f26ahr 3031 3 . . . cord-028721-x6f26ahr 3031 4 12 12 CD cord-028721-x6f26ahr 3031 5 - - SYM cord-028721-x6f26ahr 3031 6 139 139 CD cord-028721-x6f26ahr 3031 7 ) ) -RRB- cord-028721-x6f26ahr 3031 8 . . . cord-028721-x6f26ahr 3032 1 1279 1279 CD cord-028721-x6f26ahr 3033 1 During during IN cord-028721-x6f26ahr 3033 2 infancy infancy NN cord-028721-x6f26ahr 3033 3 and and CC cord-028721-x6f26ahr 3033 4 childhood childhood NN cord-028721-x6f26ahr 3033 5 , , , cord-028721-x6f26ahr 3033 6 the the DT cord-028721-x6f26ahr 3033 7 testes testis NNS cord-028721-x6f26ahr 3033 8 have have VBP cord-028721-x6f26ahr 3033 9 reduced reduce VBN cord-028721-x6f26ahr 3033 10 tubular tubular JJ cord-028721-x6f26ahr 3033 11 diameters diameter NNS cord-028721-x6f26ahr 3033 12 ; ; : cord-028721-x6f26ahr 3033 13 adults adult NNS cord-028721-x6f26ahr 3033 14 have have VBP cord-028721-x6f26ahr 3033 15 an an DT cord-028721-x6f26ahr 3033 16 infantile infantile JJ cord-028721-x6f26ahr 3033 17 pattern pattern NN cord-028721-x6f26ahr 3033 18 . . . cord-028721-x6f26ahr 3034 1 1280 1280 CD cord-028721-x6f26ahr 3035 1 This this DT cord-028721-x6f26ahr 3035 2 syndrome syndrome NN cord-028721-x6f26ahr 3035 3 is be VBZ cord-028721-x6f26ahr 3035 4 caused cause VBN cord-028721-x6f26ahr 3035 5 by by IN cord-028721-x6f26ahr 3035 6 an an DT cord-028721-x6f26ahr 3035 7 anomaly anomaly NN cord-028721-x6f26ahr 3035 8 of of IN cord-028721-x6f26ahr 3035 9 chromosome chromosome NN cord-028721-x6f26ahr 3035 10 15 15 CD cord-028721-x6f26ahr 3035 11 , , , cord-028721-x6f26ahr 3035 12 usually usually RB cord-028721-x6f26ahr 3035 13 in in IN cord-028721-x6f26ahr 3035 14 the the DT cord-028721-x6f26ahr 3035 15 15p11 15p11 CD cord-028721-x6f26ahr 3035 16 - - SYM cord-028721-x6f26ahr 3035 17 12 12 CD cord-028721-x6f26ahr 3035 18 band band NN cord-028721-x6f26ahr 3035 19 . . . cord-028721-x6f26ahr 3036 1 Other other JJ cord-028721-x6f26ahr 3036 2 chromosomal chromosomal JJ cord-028721-x6f26ahr 3036 3 anomalies anomaly NNS cord-028721-x6f26ahr 3036 4 include include VBP cord-028721-x6f26ahr 3036 5 Robertsonian robertsonian JJ cord-028721-x6f26ahr 3036 6 translocations translocation NNS cord-028721-x6f26ahr 3036 7 , , , cord-028721-x6f26ahr 3036 8 reciprocal reciprocal JJ cord-028721-x6f26ahr 3036 9 translocations translocation NNS cord-028721-x6f26ahr 3036 10 , , , cord-028721-x6f26ahr 3036 11 small small JJ cord-028721-x6f26ahr 3036 12 supernumerary supernumerary JJ cord-028721-x6f26ahr 3036 13 metacentric metacentric JJ cord-028721-x6f26ahr 3036 14 chromosomes chromosome NNS cord-028721-x6f26ahr 3036 15 , , , cord-028721-x6f26ahr 3036 16 and and CC cord-028721-x6f26ahr 3036 17 partial partial JJ cord-028721-x6f26ahr 3036 18 deletion deletion NN cord-028721-x6f26ahr 3036 19 of of IN cord-028721-x6f26ahr 3036 20 the the DT cord-028721-x6f26ahr 3036 21 long long JJ cord-028721-x6f26ahr 3036 22 arm arm NN cord-028721-x6f26ahr 3036 23 of of IN cord-028721-x6f26ahr 3036 24 chromosome chromosome NN cord-028721-x6f26ahr 3036 25 15 15 CD cord-028721-x6f26ahr 3036 26 . . . cord-028721-x6f26ahr 3037 1 This this DT cord-028721-x6f26ahr 3037 2 syndrome syndrome NN cord-028721-x6f26ahr 3037 3 is be VBZ cord-028721-x6f26ahr 3037 4 a a DT cord-028721-x6f26ahr 3037 5 pleiotropic pleiotropic JJ cord-028721-x6f26ahr 3037 6 disorder disorder NN cord-028721-x6f26ahr 3037 7 characterized characterize VBN cord-028721-x6f26ahr 3037 8 by by IN cord-028721-x6f26ahr 3037 9 obesity obesity NN cord-028721-x6f26ahr 3037 10 , , , cord-028721-x6f26ahr 3037 11 infantilism infantilism NN cord-028721-x6f26ahr 3037 12 , , , cord-028721-x6f26ahr 3037 13 short short JJ cord-028721-x6f26ahr 3037 14 stature stature NN cord-028721-x6f26ahr 3037 15 , , , cord-028721-x6f26ahr 3037 16 diabetes diabetes NN cord-028721-x6f26ahr 3037 17 insipidus insipidus NN cord-028721-x6f26ahr 3037 18 , , , cord-028721-x6f26ahr 3037 19 mental mental JJ cord-028721-x6f26ahr 3037 20 retardation retardation NN cord-028721-x6f26ahr 3037 21 , , , cord-028721-x6f26ahr 3037 22 retinitis retinitis NN cord-028721-x6f26ahr 3037 23 pigmentosa pigmentosa NN cord-028721-x6f26ahr 3037 24 , , , cord-028721-x6f26ahr 3037 25 polydactyly polydactyly NN cord-028721-x6f26ahr 3037 26 , , , cord-028721-x6f26ahr 3037 27 and and CC cord-028721-x6f26ahr 3037 28 syndactyly syndactyly RB cord-028721-x6f26ahr 3037 29 . . . cord-028721-x6f26ahr 3038 1 It -PRON- PRP cord-028721-x6f26ahr 3038 2 is be VBZ cord-028721-x6f26ahr 3038 3 more more RBR cord-028721-x6f26ahr 3038 4 frequent frequent JJ cord-028721-x6f26ahr 3038 5 in in IN cord-028721-x6f26ahr 3038 6 males male NNS cord-028721-x6f26ahr 3038 7 than than IN cord-028721-x6f26ahr 3038 8 in in IN cord-028721-x6f26ahr 3038 9 females female NNS cord-028721-x6f26ahr 3038 10 . . . cord-028721-x6f26ahr 3039 1 Men man NNS cord-028721-x6f26ahr 3039 2 with with IN cord-028721-x6f26ahr 3039 3 this this DT cord-028721-x6f26ahr 3039 4 syndrome syndrome NN cord-028721-x6f26ahr 3039 5 are be VBP cord-028721-x6f26ahr 3039 6 infertile infertile JJ cord-028721-x6f26ahr 3039 7 , , , cord-028721-x6f26ahr 3039 8 and and CC cord-028721-x6f26ahr 3039 9 about about RB cord-028721-x6f26ahr 3039 10 74 74 CD cord-028721-x6f26ahr 3039 11 % % NN cord-028721-x6f26ahr 3039 12 show show NN cord-028721-x6f26ahr 3039 13 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3039 14 . . . cord-028721-x6f26ahr 3040 1 The the DT cord-028721-x6f26ahr 3040 2 testes testis NNS cord-028721-x6f26ahr 3040 3 are be VBP cord-028721-x6f26ahr 3040 4 prepubertal prepubertal JJ cord-028721-x6f26ahr 3040 5 , , , cord-028721-x6f26ahr 3040 6 the the DT cord-028721-x6f26ahr 3040 7 scrotum scrotum NN cord-028721-x6f26ahr 3040 8 is be VBZ cord-028721-x6f26ahr 3040 9 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 3040 10 or or CC cord-028721-x6f26ahr 3040 11 bifi bifi NNP cord-028721-x6f26ahr 3040 12 d d NN cord-028721-x6f26ahr 3040 13 , , , cord-028721-x6f26ahr 3040 14 and and CC cord-028721-x6f26ahr 3040 15 the the DT cord-028721-x6f26ahr 3040 16 penis penis NN cord-028721-x6f26ahr 3040 17 is be VBZ cord-028721-x6f26ahr 3040 18 small small JJ cord-028721-x6f26ahr 3040 19 . . . cord-028721-x6f26ahr 3041 1 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 3041 2 is be VBZ cord-028721-x6f26ahr 3041 3 found find VBN cord-028721-x6f26ahr 3041 4 in in IN cord-028721-x6f26ahr 3041 5 42 42 CD cord-028721-x6f26ahr 3041 6 % % NN cord-028721-x6f26ahr 3041 7 of of IN cord-028721-x6f26ahr 3041 8 males male NNS cord-028721-x6f26ahr 3041 9 , , , cord-028721-x6f26ahr 3041 10 and and CC cord-028721-x6f26ahr 3041 11 is be VBZ cord-028721-x6f26ahr 3041 12 bilateral bilateral JJ cord-028721-x6f26ahr 3041 13 in in IN cord-028721-x6f26ahr 3041 14 28 28 CD cord-028721-x6f26ahr 3041 15 % % NN cord-028721-x6f26ahr 3041 16 . . . cord-028721-x6f26ahr 3042 1 At at RB cord-028721-x6f26ahr 3042 2 least least JJS cord-028721-x6f26ahr 3042 3 11 11 CD cord-028721-x6f26ahr 3042 4 genes gene NNS cord-028721-x6f26ahr 3042 5 responsible responsible JJ cord-028721-x6f26ahr 3042 6 for for IN cord-028721-x6f26ahr 3042 7 this this DT cord-028721-x6f26ahr 3042 8 syndrome syndrome NN cord-028721-x6f26ahr 3042 9 have have VBP cord-028721-x6f26ahr 3042 10 been be VBN cord-028721-x6f26ahr 3042 11 cloned clone VBN cord-028721-x6f26ahr 3042 12 , , , cord-028721-x6f26ahr 3042 13 and and CC cord-028721-x6f26ahr 3042 14 it -PRON- PRP cord-028721-x6f26ahr 3042 15 is be VBZ cord-028721-x6f26ahr 3042 16 probable probable JJ cord-028721-x6f26ahr 3042 17 that that IN cord-028721-x6f26ahr 3042 18 additional additional JJ cord-028721-x6f26ahr 3042 19 genes gene NNS cord-028721-x6f26ahr 3042 20 are be VBP cord-028721-x6f26ahr 3042 21 involved involve VBN cord-028721-x6f26ahr 3042 22 . . . cord-028721-x6f26ahr 3043 1 The the DT cord-028721-x6f26ahr 3043 2 function function NN cord-028721-x6f26ahr 3043 3 of of IN cord-028721-x6f26ahr 3043 4 the the DT cord-028721-x6f26ahr 3043 5 products product NNS cord-028721-x6f26ahr 3043 6 of of IN cord-028721-x6f26ahr 3043 7 these these DT cord-028721-x6f26ahr 3043 8 gene gene NN cord-028721-x6f26ahr 3043 9 is be VBZ cord-028721-x6f26ahr 3043 10 to to TO cord-028721-x6f26ahr 3043 11 mediate mediate VB cord-028721-x6f26ahr 3043 12 and and CC cord-028721-x6f26ahr 3043 13 regulate regulate VB cord-028721-x6f26ahr 3043 14 microtubule microtubule NN cord-028721-x6f26ahr 3043 15 - - HYPH cord-028721-x6f26ahr 3043 16 based base VBN cord-028721-x6f26ahr 3043 17 transport transport NN cord-028721-x6f26ahr 3043 18 processes process NNS cord-028721-x6f26ahr 3043 19 . . . cord-028721-x6f26ahr 3044 1 1281 1281 CD cord-028721-x6f26ahr 3044 2 , , , cord-028721-x6f26ahr 3044 3 1282 1282 CD cord-028721-x6f26ahr 3044 4 Hypogonadotropic Hypogonadotropic NNP cord-028721-x6f26ahr 3044 5 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3044 6 associated associate VBN cord-028721-x6f26ahr 3044 7 with with IN cord-028721-x6f26ahr 3044 8 dermatologic dermatologic JJ cord-028721-x6f26ahr 3044 9 diseases disease NNS cord-028721-x6f26ahr 3044 10 Several several JJ cord-028721-x6f26ahr 3044 11 dermatopathies dermatopathie NNS cord-028721-x6f26ahr 3044 12 are be VBP cord-028721-x6f26ahr 3044 13 associated associate VBN cord-028721-x6f26ahr 3044 14 with with IN cord-028721-x6f26ahr 3044 15 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3044 16 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3044 17 , , , cord-028721-x6f26ahr 3044 18 including include VBG cord-028721-x6f26ahr 3044 19 ichthyosis ichthyosis NN cord-028721-x6f26ahr 3044 20 and and CC cord-028721-x6f26ahr 3044 21 Johnson Johnson NNP cord-028721-x6f26ahr 3044 22 's 's POS cord-028721-x6f26ahr 3044 23 neuroectodermic neuroectodermic NNP cord-028721-x6f26ahr 3044 24 syndrome syndrome NN cord-028721-x6f26ahr 3044 25 . . . cord-028721-x6f26ahr 3045 1 Most Most JJS cord-028721-x6f26ahr 3045 2 cases case NNS cord-028721-x6f26ahr 3045 3 of of IN cord-028721-x6f26ahr 3045 4 ichthyosis ichthyosis NN cord-028721-x6f26ahr 3045 5 associated associate VBN cord-028721-x6f26ahr 3045 6 with with IN cord-028721-x6f26ahr 3045 7 hypogonadism hypogonadism NNS cord-028721-x6f26ahr 3045 8 are be VBP cord-028721-x6f26ahr 3045 9 X x NN cord-028721-x6f26ahr 3045 10 - - VBN cord-028721-x6f26ahr 3045 11 linked link VBN cord-028721-x6f26ahr 3045 12 . . . cord-028721-x6f26ahr 3046 1 About about RB cord-028721-x6f26ahr 3046 2 15 15 CD cord-028721-x6f26ahr 3046 3 % % NN cord-028721-x6f26ahr 3046 4 of of IN cord-028721-x6f26ahr 3046 5 these these DT cord-028721-x6f26ahr 3046 6 patients patient NNS cord-028721-x6f26ahr 3046 7 have have VBP cord-028721-x6f26ahr 3046 8 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3046 9 , , , cord-028721-x6f26ahr 3046 10 small small JJ cord-028721-x6f26ahr 3046 11 testes testis NNS cord-028721-x6f26ahr 3046 12 , , , cord-028721-x6f26ahr 3046 13 micropenis micropeni NNS cord-028721-x6f26ahr 3046 14 , , , cord-028721-x6f26ahr 3046 15 and and CC cord-028721-x6f26ahr 3046 16 high high JJ cord-028721-x6f26ahr 3046 17 risk risk NN cord-028721-x6f26ahr 3046 18 of of IN cord-028721-x6f26ahr 3046 19 testicular testicular JJ cord-028721-x6f26ahr 3046 20 cancer cancer NN cord-028721-x6f26ahr 3046 21 . . . cord-028721-x6f26ahr 3047 1 The the DT cord-028721-x6f26ahr 3047 2 cause cause NN cord-028721-x6f26ahr 3047 3 is be VBZ cord-028721-x6f26ahr 3047 4 a a DT cord-028721-x6f26ahr 3047 5 defective defective JJ cord-028721-x6f26ahr 3047 6 microsomal microsomal NN cord-028721-x6f26ahr 3047 7 enzyme enzyme NN cord-028721-x6f26ahr 3047 8 , , , cord-028721-x6f26ahr 3047 9 steroid steroid NN cord-028721-x6f26ahr 3047 10 sulfatase sulfatase NN cord-028721-x6f26ahr 3047 11 , , , cord-028721-x6f26ahr 3047 12 causing cause VBG cord-028721-x6f26ahr 3047 13 the the DT cord-028721-x6f26ahr 3047 14 accumulation accumulation NN cord-028721-x6f26ahr 3047 15 of of IN cord-028721-x6f26ahr 3047 16 cholesterol cholesterol NN cord-028721-x6f26ahr 3047 17 sulfate sulfate NN cord-028721-x6f26ahr 3047 18 that that WDT cord-028721-x6f26ahr 3047 19 hinders hinder VBZ cord-028721-x6f26ahr 3047 20 sloughing slough VBG cord-028721-x6f26ahr 3047 21 of of IN cord-028721-x6f26ahr 3047 22 the the DT cord-028721-x6f26ahr 3047 23 cornifi cornifi NNP cord-028721-x6f26ahr 3047 24 ed ed NNP cord-028721-x6f26ahr 3047 25 layer layer NN cord-028721-x6f26ahr 3047 26 of of IN cord-028721-x6f26ahr 3047 27 the the DT cord-028721-x6f26ahr 3047 28 epidermis epidermis NN cord-028721-x6f26ahr 3047 29 . . . cord-028721-x6f26ahr 3048 1 The the DT cord-028721-x6f26ahr 3048 2 gene gene NN cord-028721-x6f26ahr 3048 3 responsible responsible JJ cord-028721-x6f26ahr 3048 4 for for IN cord-028721-x6f26ahr 3048 5 this this DT cord-028721-x6f26ahr 3048 6 enzyme enzyme NN cord-028721-x6f26ahr 3048 7 is be VBZ cord-028721-x6f26ahr 3048 8 mapped map VBN cord-028721-x6f26ahr 3048 9 to to IN cord-028721-x6f26ahr 3048 10 Xp22,3 Xp22,3 NNP cord-028721-x6f26ahr 3048 11 . . . cord-028721-x6f26ahr 3049 1 Some some DT cord-028721-x6f26ahr 3049 2 of of IN cord-028721-x6f26ahr 3049 3 these these DT cord-028721-x6f26ahr 3049 4 patients patient NNS cord-028721-x6f26ahr 3049 5 also also RB cord-028721-x6f26ahr 3049 6 have have VBP cord-028721-x6f26ahr 3049 7 anosmia anosmia NN cord-028721-x6f26ahr 3049 8 or or CC cord-028721-x6f26ahr 3049 9 hyposmia hyposmia NN cord-028721-x6f26ahr 3049 10 owing owe VBG cord-028721-x6f26ahr 3049 11 to to IN cord-028721-x6f26ahr 3049 12 involvement involvement NN cord-028721-x6f26ahr 3049 13 of of IN cord-028721-x6f26ahr 3049 14 the the DT cord-028721-x6f26ahr 3049 15 neighboring neighboring NN cord-028721-x6f26ahr 3049 16 genes gene NNS cord-028721-x6f26ahr 3049 17 , , , cord-028721-x6f26ahr 3049 18 causing cause VBG cord-028721-x6f26ahr 3049 19 a a DT cord-028721-x6f26ahr 3049 20 contiguous contiguous JJ cord-028721-x6f26ahr 3049 21 gene gene NN cord-028721-x6f26ahr 3049 22 defect defect NN cord-028721-x6f26ahr 3049 23 . . . cord-028721-x6f26ahr 3050 1 1283 1283 CD cord-028721-x6f26ahr 3050 2 Johnson Johnson NNP cord-028721-x6f26ahr 3050 3 - - HYPH cord-028721-x6f26ahr 3050 4 McMillin McMillin NNP cord-028721-x6f26ahr 3050 5 neuroectodermic neuroectodermic NNP cord-028721-x6f26ahr 3050 6 syndrome syndrome NN cord-028721-x6f26ahr 3050 7 is be VBZ cord-028721-x6f26ahr 3050 8 a a DT cord-028721-x6f26ahr 3050 9 rare rare JJ cord-028721-x6f26ahr 3050 10 autosomal autosomal JJ cord-028721-x6f26ahr 3050 11 dominant dominant JJ cord-028721-x6f26ahr 3050 12 disorder disorder NN cord-028721-x6f26ahr 3050 13 characterized characterize VBN cord-028721-x6f26ahr 3050 14 by by IN cord-028721-x6f26ahr 3050 15 alopecia alopecia NNP cord-028721-x6f26ahr 3050 16 , , , cord-028721-x6f26ahr 3050 17 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3050 18 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3050 19 , , , cord-028721-x6f26ahr 3050 20 anosmia anosmia NN cord-028721-x6f26ahr 3050 21 or or CC cord-028721-x6f26ahr 3050 22 hyposmia hyposmia NN cord-028721-x6f26ahr 3050 23 , , , cord-028721-x6f26ahr 3050 24 deafness deafness NN cord-028721-x6f26ahr 3050 25 , , , cord-028721-x6f26ahr 3050 26 prominent prominent JJ cord-028721-x6f26ahr 3050 27 ears ear NNS cord-028721-x6f26ahr 3050 28 , , , cord-028721-x6f26ahr 3050 29 microtia microtia NN cord-028721-x6f26ahr 3050 30 and/or and/or CC cord-028721-x6f26ahr 3050 31 atresia atresia NN cord-028721-x6f26ahr 3050 32 of of IN cord-028721-x6f26ahr 3050 33 the the DT cord-028721-x6f26ahr 3050 34 external external JJ cord-028721-x6f26ahr 3050 35 auditory auditory JJ cord-028721-x6f26ahr 3050 36 meatus meatus NN cord-028721-x6f26ahr 3050 37 , , , cord-028721-x6f26ahr 3050 38 and and CC cord-028721-x6f26ahr 3050 39 a a DT cord-028721-x6f26ahr 3050 40 pronounced pronounced JJ cord-028721-x6f26ahr 3050 41 tendency tendency NN cord-028721-x6f26ahr 3050 42 to to IN cord-028721-x6f26ahr 3050 43 dental dental JJ cord-028721-x6f26ahr 3050 44 caries carie NNS cord-028721-x6f26ahr 3050 45 . . . cord-028721-x6f26ahr 3051 1 1284 1284 CD cord-028721-x6f26ahr 3051 2 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3051 3 associated associate VBN cord-028721-x6f26ahr 3051 4 with with IN cord-028721-x6f26ahr 3051 5 ataxia ataxia NN cord-028721-x6f26ahr 3051 6 is be VBZ cord-028721-x6f26ahr 3051 7 rare rare JJ cord-028721-x6f26ahr 3051 8 . . . cord-028721-x6f26ahr 3052 1 Most Most JJS cord-028721-x6f26ahr 3052 2 patients patient NNS cord-028721-x6f26ahr 3052 3 are be VBP cord-028721-x6f26ahr 3052 4 the the DT cord-028721-x6f26ahr 3052 5 offspring offspring NN cord-028721-x6f26ahr 3052 6 of of IN cord-028721-x6f26ahr 3052 7 a a DT cord-028721-x6f26ahr 3052 8 consanguineous consanguineous JJ cord-028721-x6f26ahr 3052 9 marriage marriage NN cord-028721-x6f26ahr 3052 10 . . . cord-028721-x6f26ahr 3053 1 Inheritance inheritance NN cord-028721-x6f26ahr 3053 2 is be VBZ cord-028721-x6f26ahr 3053 3 autosomal autosomal JJ cord-028721-x6f26ahr 3053 4 recessive recessive JJ cord-028721-x6f26ahr 3053 5 . . . cord-028721-x6f26ahr 3054 1 The the DT cord-028721-x6f26ahr 3054 2 most most RBS cord-028721-x6f26ahr 3054 3 frequent frequent JJ cord-028721-x6f26ahr 3054 4 syndromes syndrome NNS cord-028721-x6f26ahr 3054 5 are be VBP cord-028721-x6f26ahr 3054 6 Louis Louis NNP cord-028721-x6f26ahr 3054 7 - - HYPH cord-028721-x6f26ahr 3054 8 Bar Bar NNP cord-028721-x6f26ahr 3054 9 's 's POS cord-028721-x6f26ahr 3054 10 syndrome syndrome NN cord-028721-x6f26ahr 3054 11 ( ( -LRB- cord-028721-x6f26ahr 3054 12 ataxia ataxia NN cord-028721-x6f26ahr 3054 13 - - HYPH cord-028721-x6f26ahr 3054 14 telangiectasia telangiectasia NN cord-028721-x6f26ahr 3054 15 ) ) -RRB- cord-028721-x6f26ahr 3054 16 and and CC cord-028721-x6f26ahr 3054 17 Friedreich Friedreich NNP cord-028721-x6f26ahr 3054 18 's 's POS cord-028721-x6f26ahr 3054 19 ataxia ataxia NN cord-028721-x6f26ahr 3054 20 . . . cord-028721-x6f26ahr 3055 1 Ataxia ataxia NN cord-028721-x6f26ahr 3055 2 - - HYPH cord-028721-x6f26ahr 3055 3 telangiectasia telangiectasia NNP cord-028721-x6f26ahr 3055 4 is be VBZ cord-028721-x6f26ahr 3055 5 the the DT cord-028721-x6f26ahr 3055 6 most most RBS cord-028721-x6f26ahr 3055 7 common common JJ cord-028721-x6f26ahr 3055 8 inherited inherit VBN cord-028721-x6f26ahr 3055 9 ataxia ataxia NN cord-028721-x6f26ahr 3055 10 and and CC cord-028721-x6f26ahr 3055 11 is be VBZ cord-028721-x6f26ahr 3055 12 characterized characterize VBN cord-028721-x6f26ahr 3055 13 by by IN cord-028721-x6f26ahr 3055 14 cerebellar cerebellar JJ cord-028721-x6f26ahr 3055 15 ataxia ataxia NN cord-028721-x6f26ahr 3055 16 that that WDT cord-028721-x6f26ahr 3055 17 starts start VBZ cord-028721-x6f26ahr 3055 18 in in IN cord-028721-x6f26ahr 3055 19 infancy infancy NN cord-028721-x6f26ahr 3055 20 and and CC cord-028721-x6f26ahr 3055 21 develops develop VBZ cord-028721-x6f26ahr 3055 22 progressively progressively RB cord-028721-x6f26ahr 3055 23 ; ; : cord-028721-x6f26ahr 3055 24 mucocutaneous mucocutaneous NNP cord-028721-x6f26ahr 3055 25 telangiectasis telangiectasis NNP cord-028721-x6f26ahr 3055 26 ; ; : cord-028721-x6f26ahr 3055 27 anomalies anomaly NNS cord-028721-x6f26ahr 3055 28 of of IN cord-028721-x6f26ahr 3055 29 the the DT cord-028721-x6f26ahr 3055 30 immune immune JJ cord-028721-x6f26ahr 3055 31 system system NN cord-028721-x6f26ahr 3055 32 that that WDT cord-028721-x6f26ahr 3055 33 cause cause VBP cord-028721-x6f26ahr 3055 34 pulmonary pulmonary JJ cord-028721-x6f26ahr 3055 35 infection infection NN cord-028721-x6f26ahr 3055 36 ; ; : cord-028721-x6f26ahr 3055 37 hypersensitivity hypersensitivity NN cord-028721-x6f26ahr 3055 38 to to IN cord-028721-x6f26ahr 3055 39 ionizing ionize VBG cord-028721-x6f26ahr 3055 40 radiation radiation NN cord-028721-x6f26ahr 3055 41 owing owe VBG cord-028721-x6f26ahr 3055 42 to to IN cord-028721-x6f26ahr 3055 43 impairment impairment NN cord-028721-x6f26ahr 3055 44 of of IN cord-028721-x6f26ahr 3055 45 DNA dna NN cord-028721-x6f26ahr 3055 46 repair repair NN cord-028721-x6f26ahr 3055 47 ; ; : cord-028721-x6f26ahr 3055 48 and and CC cord-028721-x6f26ahr 3055 49 a a DT cord-028721-x6f26ahr 3055 50 high high JJ cord-028721-x6f26ahr 3055 51 risk risk NN cord-028721-x6f26ahr 3055 52 of of IN cord-028721-x6f26ahr 3055 53 lymphoid lymphoid JJ cord-028721-x6f26ahr 3055 54 neoplasia neoplasia NN cord-028721-x6f26ahr 3055 55 . . . cord-028721-x6f26ahr 3056 1 The the DT cord-028721-x6f26ahr 3056 2 gene gene NN cord-028721-x6f26ahr 3056 3 responsible responsible JJ cord-028721-x6f26ahr 3056 4 is be VBZ cord-028721-x6f26ahr 3056 5 on on IN cord-028721-x6f26ahr 3056 6 11q22-q23.1 11q22-q23.1 CD cord-028721-x6f26ahr 3056 7 . . . cord-028721-x6f26ahr 3057 1 1285 1285 CD cord-028721-x6f26ahr 3058 1 This this DT cord-028721-x6f26ahr 3058 2 ataxia ataxia NN cord-028721-x6f26ahr 3058 3 results result VBZ cord-028721-x6f26ahr 3058 4 from from IN cord-028721-x6f26ahr 3058 5 inactivation inactivation NN cord-028721-x6f26ahr 3058 6 of of IN cord-028721-x6f26ahr 3058 7 the the DT cord-028721-x6f26ahr 3058 8 A A NNP cord-028721-x6f26ahr 3058 9 - - HYPH cord-028721-x6f26ahr 3058 10 T t NN cord-028721-x6f26ahr 3058 11 mutated mutate VBN cord-028721-x6f26ahr 3058 12 ( ( -LRB- cord-028721-x6f26ahr 3058 13 ATM atm NN cord-028721-x6f26ahr 3058 14 ) ) -RRB- cord-028721-x6f26ahr 3058 15 kinase kinase NN cord-028721-x6f26ahr 3058 16 , , , cord-028721-x6f26ahr 3058 17 a a DT cord-028721-x6f26ahr 3058 18 critical critical JJ cord-028721-x6f26ahr 3058 19 protein protein NN cord-028721-x6f26ahr 3058 20 kinase kinase NN cord-028721-x6f26ahr 3058 21 that that WDT cord-028721-x6f26ahr 3058 22 regulates regulate VBZ cord-028721-x6f26ahr 3058 23 the the DT cord-028721-x6f26ahr 3058 24 response response NN cord-028721-x6f26ahr 3058 25 to to TO cord-028721-x6f26ahr 3058 26 DNA dna VB cord-028721-x6f26ahr 3058 27 double double JJ cord-028721-x6f26ahr 3058 28 - - HYPH cord-028721-x6f26ahr 3058 29 strand strand NN cord-028721-x6f26ahr 3058 30 breaks break NNS cord-028721-x6f26ahr 3058 31 by by IN cord-028721-x6f26ahr 3058 32 selective selective JJ cord-028721-x6f26ahr 3058 33 phosphorylation phosphorylation NN cord-028721-x6f26ahr 3058 34 of of IN cord-028721-x6f26ahr 3058 35 a a DT cord-028721-x6f26ahr 3058 36 variety variety NN cord-028721-x6f26ahr 3058 37 of of IN cord-028721-x6f26ahr 3058 38 substrates substrate NNS cord-028721-x6f26ahr 3058 39 . . . cord-028721-x6f26ahr 3059 1 1286 1286 CD cord-028721-x6f26ahr 3060 1 Friedreich Friedreich NNP cord-028721-x6f26ahr 3060 2 's 's POS cord-028721-x6f26ahr 3060 3 ataxia ataxia NN cord-028721-x6f26ahr 3060 4 is be VBZ cord-028721-x6f26ahr 3060 5 a a DT cord-028721-x6f26ahr 3060 6 neurodegenerative neurodegenerative JJ cord-028721-x6f26ahr 3060 7 disorder disorder NN cord-028721-x6f26ahr 3060 8 characterized characterize VBN cord-028721-x6f26ahr 3060 9 by by IN cord-028721-x6f26ahr 3060 10 degeneration degeneration NN cord-028721-x6f26ahr 3060 11 of of IN cord-028721-x6f26ahr 3060 12 dorsal dorsal JJ cord-028721-x6f26ahr 3060 13 root root NN cord-028721-x6f26ahr 3060 14 ganglia ganglion NNS cord-028721-x6f26ahr 3060 15 and and CC cord-028721-x6f26ahr 3060 16 spinocerebellar spinocerebellar JJ cord-028721-x6f26ahr 3060 17 tracts tract NNS cord-028721-x6f26ahr 3060 18 . . . cord-028721-x6f26ahr 3061 1 Hypertrophic hypertrophic JJ cord-028721-x6f26ahr 3061 2 myocardiopathy myocardiopathy NNP cord-028721-x6f26ahr 3061 3 is be VBZ cord-028721-x6f26ahr 3061 4 also also RB cord-028721-x6f26ahr 3061 5 observed observe VBN cord-028721-x6f26ahr 3061 6 in in IN cord-028721-x6f26ahr 3061 7 many many JJ cord-028721-x6f26ahr 3061 8 of of IN cord-028721-x6f26ahr 3061 9 these these DT cord-028721-x6f26ahr 3061 10 patients patient NNS cord-028721-x6f26ahr 3061 11 . . . cord-028721-x6f26ahr 3062 1 The the DT cord-028721-x6f26ahr 3062 2 incidence incidence NN cord-028721-x6f26ahr 3062 3 is be VBZ cord-028721-x6f26ahr 3062 4 estimated estimate VBN cord-028721-x6f26ahr 3062 5 at at IN cord-028721-x6f26ahr 3062 6 1 1 CD cord-028721-x6f26ahr 3062 7 in in IN cord-028721-x6f26ahr 3062 8 40 40 CD cord-028721-x6f26ahr 3062 9 000 000 CD cord-028721-x6f26ahr 3062 10 children child NNS cord-028721-x6f26ahr 3062 11 . . . cord-028721-x6f26ahr 3063 1 It -PRON- PRP cord-028721-x6f26ahr 3063 2 is be VBZ cord-028721-x6f26ahr 3063 3 caused cause VBN cord-028721-x6f26ahr 3063 4 by by IN cord-028721-x6f26ahr 3063 5 defects defect NNS cord-028721-x6f26ahr 3063 6 in in IN cord-028721-x6f26ahr 3063 7 the the DT cord-028721-x6f26ahr 3063 8 gene gene NN cord-028721-x6f26ahr 3063 9 encoding encode VBG cord-028721-x6f26ahr 3063 10 frataxin frataxin NNP cord-028721-x6f26ahr 3063 11 , , , cord-028721-x6f26ahr 3063 12 a a DT cord-028721-x6f26ahr 3063 13 protein protein NN cord-028721-x6f26ahr 3063 14 required require VBN cord-028721-x6f26ahr 3063 15 for for IN cord-028721-x6f26ahr 3063 16 vesicular vesicular JJ cord-028721-x6f26ahr 3063 17 traffi traffi NNP cord-028721-x6f26ahr 3063 18 c c NNP cord-028721-x6f26ahr 3063 19 in in IN cord-028721-x6f26ahr 3063 20 cell cell NN cord-028721-x6f26ahr 3063 21 and and CC cord-028721-x6f26ahr 3063 22 synaptic synaptic JJ cord-028721-x6f26ahr 3063 23 transmission transmission NN cord-028721-x6f26ahr 3063 24 . . . cord-028721-x6f26ahr 3064 1 1287 1287 CD cord-028721-x6f26ahr 3065 1 About about RB cord-028721-x6f26ahr 3065 2 95 95 CD cord-028721-x6f26ahr 3065 3 % % NN cord-028721-x6f26ahr 3065 4 of of IN cord-028721-x6f26ahr 3065 5 patients patient NNS cord-028721-x6f26ahr 3065 6 are be VBP cord-028721-x6f26ahr 3065 7 homozygous homozygous JJ cord-028721-x6f26ahr 3065 8 for for IN cord-028721-x6f26ahr 3065 9 an an DT cord-028721-x6f26ahr 3065 10 unstable unstable JJ cord-028721-x6f26ahr 3065 11 trinucleoid trinucleoid FW cord-028721-x6f26ahr 3065 12 ( ( -LRB- cord-028721-x6f26ahr 3065 13 GAA GAA NNP cord-028721-x6f26ahr 3065 14 ) ) -RRB- cord-028721-x6f26ahr 3065 15 expansion expansion NN cord-028721-x6f26ahr 3065 16 in in IN cord-028721-x6f26ahr 3065 17 intron intron NN cord-028721-x6f26ahr 3065 18 18 18 CD cord-028721-x6f26ahr 3065 19 of of IN cord-028721-x6f26ahr 3065 20 STM7 STM7 NNP cord-028721-x6f26ahr 3065 21 on on IN cord-028721-x6f26ahr 3065 22 9q13 9q13 CD cord-028721-x6f26ahr 3065 23 . . . cord-028721-x6f26ahr 3066 1 The the DT cord-028721-x6f26ahr 3066 2 normal normal JJ cord-028721-x6f26ahr 3066 3 gene gene NN cord-028721-x6f26ahr 3066 4 has have VBZ cord-028721-x6f26ahr 3066 5 up up IN cord-028721-x6f26ahr 3066 6 to to TO cord-028721-x6f26ahr 3066 7 35 35 CD cord-028721-x6f26ahr 3066 8 or or CC cord-028721-x6f26ahr 3066 9 40 40 CD cord-028721-x6f26ahr 3066 10 triplet triplet NN cord-028721-x6f26ahr 3066 11 repeats repeat NNS cord-028721-x6f26ahr 3066 12 , , , cord-028721-x6f26ahr 3066 13 whereas whereas IN cord-028721-x6f26ahr 3066 14 patients patient NNS cord-028721-x6f26ahr 3066 15 with with IN cord-028721-x6f26ahr 3066 16 this this DT cord-028721-x6f26ahr 3066 17 ataxia ataxia NN cord-028721-x6f26ahr 3066 18 carry carry VBP cord-028721-x6f26ahr 3066 19 70 70 CD cord-028721-x6f26ahr 3066 20 to to IN cord-028721-x6f26ahr 3066 21 more more JJR cord-028721-x6f26ahr 3066 22 than than IN cord-028721-x6f26ahr 3066 23 1000 1000 CD cord-028721-x6f26ahr 3066 24 GAA GAA NNP cord-028721-x6f26ahr 3066 25 triplets triplet NNS cord-028721-x6f26ahr 3066 26 . . . cord-028721-x6f26ahr 3067 1 1288 1288 CD cord-028721-x6f26ahr 3068 1 The the DT cord-028721-x6f26ahr 3068 2 normal normal JJ cord-028721-x6f26ahr 3068 3 gene gene NN cord-028721-x6f26ahr 3068 4 has have VBZ cord-028721-x6f26ahr 3068 5 seven seven CD cord-028721-x6f26ahr 3068 6 to to TO cord-028721-x6f26ahr 3068 7 22 22 CD cord-028721-x6f26ahr 3068 8 GAA GAA NNP cord-028721-x6f26ahr 3068 9 repeats repeat VBZ cord-028721-x6f26ahr 3068 10 , , , cord-028721-x6f26ahr 3068 11 whereas whereas IN cord-028721-x6f26ahr 3068 12 the the DT cord-028721-x6f26ahr 3068 13 mutated mutate VBN cord-028721-x6f26ahr 3068 14 gene gene NN cord-028721-x6f26ahr 3068 15 has have VBZ cord-028721-x6f26ahr 3068 16 over over IN cord-028721-x6f26ahr 3068 17 120 120 CD cord-028721-x6f26ahr 3068 18 repeats repeat NNS cord-028721-x6f26ahr 3068 19 . . . cord-028721-x6f26ahr 3069 1 The the DT cord-028721-x6f26ahr 3069 2 extent extent NN cord-028721-x6f26ahr 3069 3 of of IN cord-028721-x6f26ahr 3069 4 the the DT cord-028721-x6f26ahr 3069 5 expanded expand VBN cord-028721-x6f26ahr 3069 6 allele allele NN cord-028721-x6f26ahr 3069 7 is be VBZ cord-028721-x6f26ahr 3069 8 directly directly RB cord-028721-x6f26ahr 3069 9 proportional proportional JJ cord-028721-x6f26ahr 3069 10 to to IN cord-028721-x6f26ahr 3069 11 the the DT cord-028721-x6f26ahr 3069 12 severity severity NN cord-028721-x6f26ahr 3069 13 of of IN cord-028721-x6f26ahr 3069 14 disease disease NN cord-028721-x6f26ahr 3069 15 , , , cord-028721-x6f26ahr 3069 16 early early JJ cord-028721-x6f26ahr 3069 17 onset onset NN cord-028721-x6f26ahr 3069 18 of of IN cord-028721-x6f26ahr 3069 19 disease disease NN cord-028721-x6f26ahr 3069 20 , , , cord-028721-x6f26ahr 3069 21 and and CC cord-028721-x6f26ahr 3069 22 development development NN cord-028721-x6f26ahr 3069 23 of of IN cord-028721-x6f26ahr 3069 24 cardiac cardiac JJ cord-028721-x6f26ahr 3069 25 abnormalities abnormality NNS cord-028721-x6f26ahr 3069 26 . . . cord-028721-x6f26ahr 3070 1 Other other JJ cord-028721-x6f26ahr 3070 2 ataxias ataxias NNP cord-028721-x6f26ahr 3070 3 associated associate VBN cord-028721-x6f26ahr 3070 4 with with IN cord-028721-x6f26ahr 3070 5 hypogonadism hypogonadism NNS cord-028721-x6f26ahr 3070 6 are be VBP cord-028721-x6f26ahr 3070 7 Kearns Kearns NNP cord-028721-x6f26ahr 3070 8 - - HYPH cord-028721-x6f26ahr 3070 9 Sayre Sayre NNP cord-028721-x6f26ahr 3070 10 , , , cord-028721-x6f26ahr 3070 11 Boucher Boucher NNP cord-028721-x6f26ahr 3070 12 - - HYPH cord-028721-x6f26ahr 3070 13 Neuhauser Neuhauser NNP cord-028721-x6f26ahr 3070 14 , , , cord-028721-x6f26ahr 3070 15 and and CC cord-028721-x6f26ahr 3070 16 Gordon Gordon NNP cord-028721-x6f26ahr 3070 17 - - HYPH cord-028721-x6f26ahr 3070 18 Holmes Holmes NNP cord-028721-x6f26ahr 3070 19 syndromes syndrome NNS cord-028721-x6f26ahr 3070 20 . . . cord-028721-x6f26ahr 3071 1 Hypogonadotropic Hypogonadotropic NNP cord-028721-x6f26ahr 3071 2 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3071 3 may may MD cord-028721-x6f26ahr 3071 4 also also RB cord-028721-x6f26ahr 3071 5 be be VB cord-028721-x6f26ahr 3071 6 present present JJ cord-028721-x6f26ahr 3071 7 in in IN cord-028721-x6f26ahr 3071 8 Carpenter Carpenter NNP cord-028721-x6f26ahr 3071 9 's 's POS cord-028721-x6f26ahr 3071 10 , , , cord-028721-x6f26ahr 3071 11 Biemond Biemond NNP cord-028721-x6f26ahr 3071 12 's 's POS cord-028721-x6f26ahr 3071 13 , , , cord-028721-x6f26ahr 3071 14 Fraser Fraser NNP cord-028721-x6f26ahr 3071 15 's 's POS cord-028721-x6f26ahr 3071 16 , , , cord-028721-x6f26ahr 3071 17 and and CC cord-028721-x6f26ahr 3071 18 Moebius Moebius NNP cord-028721-x6f26ahr 3071 19 ' ' POS cord-028721-x6f26ahr 3071 20 syndromes syndrome NNS cord-028721-x6f26ahr 3071 21 , , , cord-028721-x6f26ahr 3071 22 and and CC cord-028721-x6f26ahr 3071 23 in in IN cord-028721-x6f26ahr 3071 24 patients patient NNS cord-028721-x6f26ahr 3071 25 with with IN cord-028721-x6f26ahr 3071 26 mental mental JJ cord-028721-x6f26ahr 3071 27 retardation retardation NN cord-028721-x6f26ahr 3071 28 . . . cord-028721-x6f26ahr 3072 1 Maintenance maintenance NN cord-028721-x6f26ahr 3072 2 of of IN cord-028721-x6f26ahr 3072 3 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3072 4 requires require VBZ cord-028721-x6f26ahr 3072 5 the the DT cord-028721-x6f26ahr 3072 6 harmonious harmonious JJ cord-028721-x6f26ahr 3072 7 cooperation cooperation NN cord-028721-x6f26ahr 3072 8 of of IN cord-028721-x6f26ahr 3072 9 several several JJ cord-028721-x6f26ahr 3072 10 endocrine endocrine JJ cord-028721-x6f26ahr 3072 11 glands gland NNS cord-028721-x6f26ahr 3072 12 and and CC cord-028721-x6f26ahr 3072 13 proper proper JJ cord-028721-x6f26ahr 3072 14 functioning functioning NN cord-028721-x6f26ahr 3072 15 of of IN cord-028721-x6f26ahr 3072 16 other other JJ cord-028721-x6f26ahr 3072 17 tissues tissue NNS cord-028721-x6f26ahr 3072 18 . . . cord-028721-x6f26ahr 3073 1 Symptomatic symptomatic JJ cord-028721-x6f26ahr 3073 2 endocrinopathy endocrinopathy NN cord-028721-x6f26ahr 3073 3 is be VBZ cord-028721-x6f26ahr 3073 4 present present JJ cord-028721-x6f26ahr 3073 5 in in IN cord-028721-x6f26ahr 3073 6 only only RB cord-028721-x6f26ahr 3073 7 1.7 1.7 CD cord-028721-x6f26ahr 3073 8 % % NN cord-028721-x6f26ahr 3073 9 of of IN cord-028721-x6f26ahr 3073 10 infertile infertile JJ cord-028721-x6f26ahr 3073 11 men man NNS cord-028721-x6f26ahr 3073 12 , , , cord-028721-x6f26ahr 3073 13 but but CC cord-028721-x6f26ahr 3073 14 over over IN cord-028721-x6f26ahr 3073 15 9 9 CD cord-028721-x6f26ahr 3073 16 % % NN cord-028721-x6f26ahr 3073 17 of of IN cord-028721-x6f26ahr 3073 18 infertile infertile JJ cord-028721-x6f26ahr 3073 19 patients patient NNS cord-028721-x6f26ahr 3073 20 have have VBP cord-028721-x6f26ahr 3073 21 abnormalities abnormality NNS cord-028721-x6f26ahr 3073 22 in in IN cord-028721-x6f26ahr 3073 23 their -PRON- PRP$ cord-028721-x6f26ahr 3073 24 endocrine endocrine JJ cord-028721-x6f26ahr 3073 25 studies study NNS cord-028721-x6f26ahr 3073 26 . . . cord-028721-x6f26ahr 3074 1 1289 1289 CD cord-028721-x6f26ahr 3074 2 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 3074 3 may may MD cord-028721-x6f26ahr 3074 4 be be VB cord-028721-x6f26ahr 3074 5 present present JJ cord-028721-x6f26ahr 3074 6 in in IN cord-028721-x6f26ahr 3074 7 disorders disorder NNS cord-028721-x6f26ahr 3074 8 involving involve VBG cord-028721-x6f26ahr 3074 9 the the DT cord-028721-x6f26ahr 3074 10 hypothalamus hypothalamus NN cord-028721-x6f26ahr 3074 11 - - HYPH cord-028721-x6f26ahr 3074 12 hypophysis hypophysis NN cord-028721-x6f26ahr 3074 13 , , , cord-028721-x6f26ahr 3074 14 thyroid thyroid NN cord-028721-x6f26ahr 3074 15 , , , cord-028721-x6f26ahr 3074 16 adrenals adrenal NNS cord-028721-x6f26ahr 3074 17 , , , cord-028721-x6f26ahr 3074 18 pancreas pancrea NNS cord-028721-x6f26ahr 3074 19 , , , cord-028721-x6f26ahr 3074 20 liver liver NN cord-028721-x6f26ahr 3074 21 , , , cord-028721-x6f26ahr 3074 22 kidney kidney NN cord-028721-x6f26ahr 3074 23 , , , cord-028721-x6f26ahr 3074 24 and and CC cord-028721-x6f26ahr 3074 25 gastrointestinal gastrointestinal JJ cord-028721-x6f26ahr 3074 26 tract tract NN cord-028721-x6f26ahr 3074 27 , , , cord-028721-x6f26ahr 3074 28 and and CC cord-028721-x6f26ahr 3074 29 may may MD cord-028721-x6f26ahr 3074 30 be be VB cord-028721-x6f26ahr 3074 31 associated associate VBN cord-028721-x6f26ahr 3074 32 with with IN cord-028721-x6f26ahr 3074 33 AIDS AIDS NNP cord-028721-x6f26ahr 3074 34 , , , cord-028721-x6f26ahr 3074 35 chronic chronic JJ cord-028721-x6f26ahr 3074 36 anemia anemia NN cord-028721-x6f26ahr 3074 37 , , , cord-028721-x6f26ahr 3074 38 obesity obesity NN cord-028721-x6f26ahr 3074 39 , , , cord-028721-x6f26ahr 3074 40 lysosomal lysosomal NN cord-028721-x6f26ahr 3074 41 and and CC cord-028721-x6f26ahr 3074 42 peroxisomal peroxisomal JJ cord-028721-x6f26ahr 3074 43 diseases disease NNS cord-028721-x6f26ahr 3074 44 , , , cord-028721-x6f26ahr 3074 45 and and CC cord-028721-x6f26ahr 3074 46 neoplasia neoplasia NN cord-028721-x6f26ahr 3074 47 . . . cord-028721-x6f26ahr 3075 1 Hypogonadotropic Hypogonadotropic NNP cord-028721-x6f26ahr 3075 2 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3075 3 can can MD cord-028721-x6f26ahr 3075 4 also also RB cord-028721-x6f26ahr 3075 5 be be VB cord-028721-x6f26ahr 3075 6 found find VBN cord-028721-x6f26ahr 3075 7 in in IN cord-028721-x6f26ahr 3075 8 some some DT cord-028721-x6f26ahr 3075 9 ( ( -LRB- cord-028721-x6f26ahr 3075 10 usually usually RB cord-028721-x6f26ahr 3075 11 women woman NNS cord-028721-x6f26ahr 3075 12 ) ) -RRB- cord-028721-x6f26ahr 3075 13 who who WP cord-028721-x6f26ahr 3075 14 perform perform VBP cord-028721-x6f26ahr 3075 15 rigorous rigorous JJ cord-028721-x6f26ahr 3075 16 sports sport NNS cord-028721-x6f26ahr 3075 17 ( ( -LRB- cord-028721-x6f26ahr 3075 18 long long JJ cord-028721-x6f26ahr 3075 19 - - HYPH cord-028721-x6f26ahr 3075 20 distance distance NN cord-028721-x6f26ahr 3075 21 runners runner NNS cord-028721-x6f26ahr 3075 22 , , , cord-028721-x6f26ahr 3075 23 swimmers swimmer NNS cord-028721-x6f26ahr 3075 24 , , , cord-028721-x6f26ahr 3075 25 dancers dancer NNS cord-028721-x6f26ahr 3075 26 , , , cord-028721-x6f26ahr 3075 27 and and CC cord-028721-x6f26ahr 3075 28 rhythmic rhythmic JJ cord-028721-x6f26ahr 3075 29 gymnasts gymnast NNS cord-028721-x6f26ahr 3075 30 ) ) -RRB- cord-028721-x6f26ahr 3075 31 . . . cord-028721-x6f26ahr 3076 1 1290 1290 CD cord-028721-x6f26ahr 3076 2 Hypopituitarism Hypopituitarism NNP cord-028721-x6f26ahr 3076 3 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 3076 4 may may MD cord-028721-x6f26ahr 3076 5 result result VB cord-028721-x6f26ahr 3076 6 from from IN cord-028721-x6f26ahr 3076 7 destruction destruction NN cord-028721-x6f26ahr 3076 8 of of IN cord-028721-x6f26ahr 3076 9 the the DT cord-028721-x6f26ahr 3076 10 hypothalamus hypothalamus NN cord-028721-x6f26ahr 3076 11 or or CC cord-028721-x6f26ahr 3076 12 hypophysis hypophysis NN cord-028721-x6f26ahr 3076 13 by by IN cord-028721-x6f26ahr 3076 14 primary primary JJ cord-028721-x6f26ahr 3076 15 or or CC cord-028721-x6f26ahr 3076 16 secondary secondary JJ cord-028721-x6f26ahr 3076 17 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 3076 18 tumor tumor NN cord-028721-x6f26ahr 3076 19 ; ; , cord-028721-x6f26ahr 3076 20 granulomatous granulomatous JJ cord-028721-x6f26ahr 3076 21 disease disease NN cord-028721-x6f26ahr 3076 22 ( ( -LRB- cord-028721-x6f26ahr 3076 23 Fig Fig NNP cord-028721-x6f26ahr 3076 24 . . . cord-028721-x6f26ahr 3076 25 12 12 CD cord-028721-x6f26ahr 3076 26 - - SYM cord-028721-x6f26ahr 3076 27 140 140 CD cord-028721-x6f26ahr 3076 28 ) ) -RRB- cord-028721-x6f26ahr 3076 29 ; ; : cord-028721-x6f26ahr 3076 30 fracture fracture VB cord-028721-x6f26ahr 3076 31 Infertility infertility NN cord-028721-x6f26ahr 3076 32 of of IN cord-028721-x6f26ahr 3076 33 the the DT cord-028721-x6f26ahr 3076 34 cranial cranial JJ cord-028721-x6f26ahr 3076 35 base base NN cord-028721-x6f26ahr 3076 36 ; ; , cord-028721-x6f26ahr 3076 37 radiotherapy radiotherapy NN cord-028721-x6f26ahr 3076 38 for for IN cord-028721-x6f26ahr 3076 39 malignancy malignancy NN cord-028721-x6f26ahr 3076 40 of of IN cord-028721-x6f26ahr 3076 41 the the DT cord-028721-x6f26ahr 3076 42 nasopharynx nasopharynx NN cord-028721-x6f26ahr 3076 43 , , , cord-028721-x6f26ahr 3076 44 central central JJ cord-028721-x6f26ahr 3076 45 nervous nervous JJ cord-028721-x6f26ahr 3076 46 system system NN cord-028721-x6f26ahr 3076 47 , , , cord-028721-x6f26ahr 3076 48 or or CC cord-028721-x6f26ahr 3076 49 the the DT cord-028721-x6f26ahr 3076 50 eye eye NN cord-028721-x6f26ahr 3076 51 orbit orbit NN cord-028721-x6f26ahr 3076 52 ; ; : cord-028721-x6f26ahr 3076 53 pituitary pituitary JJ cord-028721-x6f26ahr 3076 54 adenoma adenoma NN cord-028721-x6f26ahr 3076 55 and and CC cord-028721-x6f26ahr 3076 56 cyst cyst NN cord-028721-x6f26ahr 3076 57 ; ; : cord-028721-x6f26ahr 3076 58 aneurysm aneurysm NN cord-028721-x6f26ahr 3076 59 of of IN cord-028721-x6f26ahr 3076 60 the the DT cord-028721-x6f26ahr 3076 61 inner inner JJ cord-028721-x6f26ahr 3076 62 carotid carotid JJ cord-028721-x6f26ahr 3076 63 artery artery NN cord-028721-x6f26ahr 3076 64 ; ; : cord-028721-x6f26ahr 3076 65 and and CC cord-028721-x6f26ahr 3076 66 chronic chronic JJ cord-028721-x6f26ahr 3076 67 and and CC cord-028721-x6f26ahr 3076 68 nutritional nutritional JJ cord-028721-x6f26ahr 3076 69 disease disease NN cord-028721-x6f26ahr 3076 70 . . . cord-028721-x6f26ahr 3077 1 Many many JJ cord-028721-x6f26ahr 3077 2 of of IN cord-028721-x6f26ahr 3077 3 these these DT cord-028721-x6f26ahr 3077 4 processes process NNS cord-028721-x6f26ahr 3077 5 cause cause VBP cord-028721-x6f26ahr 3077 6 panhypopituitarism panhypopituitarism NN cord-028721-x6f26ahr 3077 7 with with IN cord-028721-x6f26ahr 3077 8 varied varied JJ cord-028721-x6f26ahr 3077 9 symptoms symptom NNS cord-028721-x6f26ahr 3077 10 . . . cord-028721-x6f26ahr 3078 1 1291 1291 CD cord-028721-x6f26ahr 3078 2 Clinical clinical JJ cord-028721-x6f26ahr 3078 3 manifestations manifestation NNS cord-028721-x6f26ahr 3078 4 of of IN cord-028721-x6f26ahr 3078 5 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3078 6 in in IN cord-028721-x6f26ahr 3078 7 patients patient NNS cord-028721-x6f26ahr 3078 8 with with IN cord-028721-x6f26ahr 3078 9 pituitary pituitary JJ cord-028721-x6f26ahr 3078 10 lesions lesion NNS cord-028721-x6f26ahr 3078 11 vary vary VBP cord-028721-x6f26ahr 3078 12 according accord VBG cord-028721-x6f26ahr 3078 13 to to IN cord-028721-x6f26ahr 3078 14 time time NN cord-028721-x6f26ahr 3078 15 of of IN cord-028721-x6f26ahr 3078 16 onset onset NN cord-028721-x6f26ahr 3078 17 ( ( -LRB- cord-028721-x6f26ahr 3078 18 childhood childhood NN cord-028721-x6f26ahr 3078 19 , , , cord-028721-x6f26ahr 3078 20 or or CC cord-028721-x6f26ahr 3078 21 after after IN cord-028721-x6f26ahr 3078 22 puberty puberty NN cord-028721-x6f26ahr 3078 23 ) ) -RRB- cord-028721-x6f26ahr 3078 24 . . . cord-028721-x6f26ahr 3079 1 In in IN cord-028721-x6f26ahr 3079 2 prepubertal prepubertal JJ cord-028721-x6f26ahr 3079 3 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 3079 4 the the DT cord-028721-x6f26ahr 3079 5 testes testis NNS cord-028721-x6f26ahr 3079 6 retain retain VBP cord-028721-x6f26ahr 3079 7 an an DT cord-028721-x6f26ahr 3079 8 infantile infantile JJ cord-028721-x6f26ahr 3079 9 appearance appearance NN cord-028721-x6f26ahr 3079 10 into into IN cord-028721-x6f26ahr 3079 11 adulthood adulthood NN cord-028721-x6f26ahr 3079 12 , , , cord-028721-x6f26ahr 3079 13 and and CC cord-028721-x6f26ahr 3079 14 there there EX cord-028721-x6f26ahr 3079 15 is be VBZ cord-028721-x6f26ahr 3079 16 rarely rarely RB cord-028721-x6f26ahr 3079 17 proliferation proliferation NN cord-028721-x6f26ahr 3079 18 of of IN cord-028721-x6f26ahr 3079 19 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3079 20 and and CC cord-028721-x6f26ahr 3079 21 the the DT cord-028721-x6f26ahr 3079 22 development development NN cord-028721-x6f26ahr 3079 23 of of IN cord-028721-x6f26ahr 3079 24 primary primary JJ cord-028721-x6f26ahr 3079 25 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 3079 26 . . . cord-028721-x6f26ahr 3080 1 Biopsy biopsy NN cord-028721-x6f26ahr 3080 2 shows show VBZ cord-028721-x6f26ahr 3080 3 variable variable JJ cord-028721-x6f26ahr 3080 4 hyalinization hyalinization NN cord-028721-x6f26ahr 3080 5 of of IN cord-028721-x6f26ahr 3080 6 tubules tubule NNS cord-028721-x6f26ahr 3080 7 . . . cord-028721-x6f26ahr 3081 1 In in IN cord-028721-x6f26ahr 3081 2 postpubertal postpubertal JJ cord-028721-x6f26ahr 3081 3 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 3081 4 the the DT cord-028721-x6f26ahr 3081 5 appearance appearance NN cord-028721-x6f26ahr 3081 6 ranges range VBZ cord-028721-x6f26ahr 3081 7 from from IN cord-028721-x6f26ahr 3081 8 complete complete JJ cord-028721-x6f26ahr 3081 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3081 10 to to IN cord-028721-x6f26ahr 3081 11 tubular tubular JJ cord-028721-x6f26ahr 3081 12 hyalinization hyalinization NN cord-028721-x6f26ahr 3082 1 ( ( -LRB- cord-028721-x6f26ahr 3082 2 Fig Fig NNP cord-028721-x6f26ahr 3082 3 . . . cord-028721-x6f26ahr 3082 4 12 12 CD cord-028721-x6f26ahr 3082 5 - - SYM cord-028721-x6f26ahr 3082 6 141 141 CD cord-028721-x6f26ahr 3082 7 ) ) -RRB- cord-028721-x6f26ahr 3082 8 . . . cord-028721-x6f26ahr 3083 1 The the DT cord-028721-x6f26ahr 3083 2 presence presence NN cord-028721-x6f26ahr 3083 3 of of IN cord-028721-x6f26ahr 3083 4 elastic elastic JJ cord-028721-x6f26ahr 3083 5 fi fi NNP cord-028721-x6f26ahr 3083 6 bers ber NNS cord-028721-x6f26ahr 3083 7 in in IN cord-028721-x6f26ahr 3083 8 tubular tubular JJ cord-028721-x6f26ahr 3083 9 walls wall NNS cord-028721-x6f26ahr 3083 10 indicates indicate VBZ cord-028721-x6f26ahr 3083 11 that that IN cord-028721-x6f26ahr 3083 12 pubertal pubertal JJ cord-028721-x6f26ahr 3083 13 maturation maturation NN cord-028721-x6f26ahr 3083 14 occurred occur VBD cord-028721-x6f26ahr 3083 15 before before IN cord-028721-x6f26ahr 3083 16 the the DT cord-028721-x6f26ahr 3083 17 development development NN cord-028721-x6f26ahr 3083 18 of of IN cord-028721-x6f26ahr 3083 19 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 3083 20 . . . cord-028721-x6f26ahr 3084 1 Leydig leydig NN cord-028721-x6f26ahr 3084 2 cells cell NNS cord-028721-x6f26ahr 3084 3 have have VBP cord-028721-x6f26ahr 3084 4 pyknotic pyknotic JJ cord-028721-x6f26ahr 3084 5 nuclei nucleus NNS cord-028721-x6f26ahr 3084 6 and and CC cord-028721-x6f26ahr 3084 7 retracted retract VBN cord-028721-x6f26ahr 3084 8 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3084 9 with with IN cord-028721-x6f26ahr 3084 10 abundant abundant JJ cord-028721-x6f26ahr 3084 11 lipofuscin lipofuscin NNS cord-028721-x6f26ahr 3084 12 . . . cord-028721-x6f26ahr 3085 1 In in IN cord-028721-x6f26ahr 3085 2 some some DT cord-028721-x6f26ahr 3085 3 patients patient NNS cord-028721-x6f26ahr 3085 4 , , , cord-028721-x6f26ahr 3085 5 recovery recovery NN cord-028721-x6f26ahr 3085 6 of of IN cord-028721-x6f26ahr 3085 7 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3085 8 occurs occur VBZ cord-028721-x6f26ahr 3085 9 after after IN cord-028721-x6f26ahr 3085 10 administration administration NN cord-028721-x6f26ahr 3085 11 of of IN cord-028721-x6f26ahr 3085 12 human human JJ cord-028721-x6f26ahr 3085 13 chorionic chorionic JJ cord-028721-x6f26ahr 3085 14 gonadotropin gonadotropin NN cord-028721-x6f26ahr 3085 15 . . . cord-028721-x6f26ahr 3086 1 1292 1292 CD cord-028721-x6f26ahr 3087 1 There there EX cord-028721-x6f26ahr 3087 2 are be VBP cord-028721-x6f26ahr 3087 3 cases case NNS cord-028721-x6f26ahr 3087 4 in in IN cord-028721-x6f26ahr 3087 5 which which WDT cord-028721-x6f26ahr 3087 6 pituitary pituitary JJ cord-028721-x6f26ahr 3087 7 adenoma adenoma NN cord-028721-x6f26ahr 3087 8 secretes secrete VBZ cord-028721-x6f26ahr 3087 9 both both CC cord-028721-x6f26ahr 3087 10 FSH fsh NN cord-028721-x6f26ahr 3087 11 and and CC cord-028721-x6f26ahr 3087 12 LH LH NNP cord-028721-x6f26ahr 3087 13 , , , cord-028721-x6f26ahr 3087 14 inducing induce VBG cord-028721-x6f26ahr 3087 15 testosterone testosterone NN cord-028721-x6f26ahr 3087 16 hypersecretion hypersecretion NN cord-028721-x6f26ahr 3087 17 and and CC cord-028721-x6f26ahr 3087 18 an an DT cord-028721-x6f26ahr 3087 19 elevated elevated JJ cord-028721-x6f26ahr 3087 20 sperm sperm NN cord-028721-x6f26ahr 3087 21 count count NN cord-028721-x6f26ahr 3087 22 . . . cord-028721-x6f26ahr 3088 1 1293 1293 CD cord-028721-x6f26ahr 3088 2 FSH fsh NN cord-028721-x6f26ahr 3088 3 - - HYPH cord-028721-x6f26ahr 3088 4 secreting secrete VBG cord-028721-x6f26ahr 3088 5 pituitary pituitary JJ cord-028721-x6f26ahr 3088 6 adenoma adenoma NN cord-028721-x6f26ahr 3088 7 associated associate VBN cord-028721-x6f26ahr 3088 8 with with IN cord-028721-x6f26ahr 3088 9 large large JJ cord-028721-x6f26ahr 3088 10 testes testis NNS cord-028721-x6f26ahr 3088 11 and and CC cord-028721-x6f26ahr 3088 12 increased increase VBN cord-028721-x6f26ahr 3088 13 serum serum NN cord-028721-x6f26ahr 3088 14 inhibin inhibin NN cord-028721-x6f26ahr 3088 15 concentration concentration NN cord-028721-x6f26ahr 3088 16 has have VBZ cord-028721-x6f26ahr 3088 17 been be VBN cord-028721-x6f26ahr 3088 18 reported report VBN cord-028721-x6f26ahr 3088 19 . . . cord-028721-x6f26ahr 3089 1 1294 1294 CD cord-028721-x6f26ahr 3089 2 Hyperprolactinemia Hyperprolactinemia NNP cord-028721-x6f26ahr 3089 3 Prolactin Prolactin NNP cord-028721-x6f26ahr 3089 4 inhibits inhibit VBZ cord-028721-x6f26ahr 3089 5 GnRH gnrh JJ cord-028721-x6f26ahr 3089 6 secretion secretion NN cord-028721-x6f26ahr 3089 7 and and CC cord-028721-x6f26ahr 3089 8 hence hence RB cord-028721-x6f26ahr 3089 9 FSH FSH NNP cord-028721-x6f26ahr 3089 10 and and CC cord-028721-x6f26ahr 3089 11 LH LH NNP cord-028721-x6f26ahr 3089 12 secretion secretion NN cord-028721-x6f26ahr 3089 13 . . . cord-028721-x6f26ahr 3090 1 In in IN cord-028721-x6f26ahr 3090 2 addition addition NN cord-028721-x6f26ahr 3090 3 , , , cord-028721-x6f26ahr 3090 4 prolactin prolactin NN cord-028721-x6f26ahr 3090 5 has have VBZ cord-028721-x6f26ahr 3090 6 a a DT cord-028721-x6f26ahr 3090 7 direct direct JJ cord-028721-x6f26ahr 3090 8 inhibitory inhibitory JJ cord-028721-x6f26ahr 3090 9 effect effect NN cord-028721-x6f26ahr 3090 10 on on IN cord-028721-x6f26ahr 3090 11 androgens androgen NNS cord-028721-x6f26ahr 3090 12 in in IN cord-028721-x6f26ahr 3090 13 target target NN cord-028721-x6f26ahr 3090 14 tissues tissue NNS cord-028721-x6f26ahr 3090 15 . . . cord-028721-x6f26ahr 3091 1 In in IN cord-028721-x6f26ahr 3091 2 men man NNS cord-028721-x6f26ahr 3091 3 , , , cord-028721-x6f26ahr 3091 4 hyperprolactinemia hyperprolactinemia NN cord-028721-x6f26ahr 3091 5 causes cause VBZ cord-028721-x6f26ahr 3091 6 impairment impairment NN cord-028721-x6f26ahr 3091 7 of of IN cord-028721-x6f26ahr 3091 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3091 9 , , , cord-028721-x6f26ahr 3091 10 impotence impotence NN cord-028721-x6f26ahr 3091 11 , , , cord-028721-x6f26ahr 3091 12 loss loss NN cord-028721-x6f26ahr 3091 13 of of IN cord-028721-x6f26ahr 3091 14 libido libido NN cord-028721-x6f26ahr 3091 15 , , , cord-028721-x6f26ahr 3091 16 and and CC cord-028721-x6f26ahr 3091 17 depressed depressed JJ cord-028721-x6f26ahr 3091 18 serum serum NN cord-028721-x6f26ahr 3091 19 testosterone testosterone NN cord-028721-x6f26ahr 3091 20 . . . cord-028721-x6f26ahr 3092 1 1295 1295 CD cord-028721-x6f26ahr 3093 1 Some some DT cord-028721-x6f26ahr 3093 2 patients patient NNS cord-028721-x6f26ahr 3093 3 seek seek VBP cord-028721-x6f26ahr 3093 4 treatment treatment NN cord-028721-x6f26ahr 3093 5 because because IN cord-028721-x6f26ahr 3093 6 of of IN cord-028721-x6f26ahr 3093 7 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3093 8 and and CC cord-028721-x6f26ahr 3093 9 infertility infertility NN cord-028721-x6f26ahr 3093 10 . . . cord-028721-x6f26ahr 3094 1 Hyperprolactinemia Hyperprolactinemia NNP cord-028721-x6f26ahr 3094 2 is be VBZ cord-028721-x6f26ahr 3094 3 also also RB cord-028721-x6f26ahr 3094 4 associated associate VBN cord-028721-x6f26ahr 3094 5 with with IN cord-028721-x6f26ahr 3094 6 dysfunction dysfunction NN cord-028721-x6f26ahr 3094 7 of of IN cord-028721-x6f26ahr 3094 8 prolactin prolactin NN cord-028721-x6f26ahr 3094 9 receptors receptor NNS cord-028721-x6f26ahr 3094 10 . . . cord-028721-x6f26ahr 3095 1 1296 1296 CD cord-028721-x6f26ahr 3096 1 Spermiograms Spermiograms NNP cord-028721-x6f26ahr 3096 2 usually usually RB cord-028721-x6f26ahr 3096 3 show show VBP cord-028721-x6f26ahr 3096 4 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3096 5 and and CC cord-028721-x6f26ahr 3096 6 an an DT cord-028721-x6f26ahr 3096 7 elevated elevated JJ cord-028721-x6f26ahr 3096 8 level level NN cord-028721-x6f26ahr 3096 9 of of IN cord-028721-x6f26ahr 3096 10 fructose fructose NN cord-028721-x6f26ahr 3096 11 , , , cord-028721-x6f26ahr 3096 12 1287 1287 CD cord-028721-x6f26ahr 3096 13 although although IN cord-028721-x6f26ahr 3096 14 not not RB cord-028721-x6f26ahr 3096 15 all all DT cord-028721-x6f26ahr 3096 16 males male NNS cord-028721-x6f26ahr 3096 17 with with IN cord-028721-x6f26ahr 3096 18 hyperprolactinemia hyperprolactinemia NNP cord-028721-x6f26ahr 3096 19 have have VBP cord-028721-x6f26ahr 3096 20 subnormal subnormal JJ cord-028721-x6f26ahr 3096 21 testicular testicular JJ cord-028721-x6f26ahr 3096 22 function function NN cord-028721-x6f26ahr 3096 23 . . . cord-028721-x6f26ahr 3097 1 1298 1298 CD cord-028721-x6f26ahr 3097 2 Testicular Testicular NNP cord-028721-x6f26ahr 3097 3 biopsy biopsy NN cord-028721-x6f26ahr 3097 4 reveals reveal VBZ cord-028721-x6f26ahr 3097 5 variable variable JJ cord-028721-x6f26ahr 3097 6 testicular testicular JJ cord-028721-x6f26ahr 3097 7 atrophy atrophy NN cord-028721-x6f26ahr 3097 8 . . . cord-028721-x6f26ahr 3098 1 The the DT cord-028721-x6f26ahr 3098 2 most most RBS cord-028721-x6f26ahr 3098 3 frequent frequent JJ cord-028721-x6f26ahr 3098 4 lesion lesion NN cord-028721-x6f26ahr 3098 5 is be VBZ cord-028721-x6f26ahr 3098 6 in in IN cord-028721-x6f26ahr 3098 7 the the DT cord-028721-x6f26ahr 3098 8 tubular tubular JJ cord-028721-x6f26ahr 3098 9 adluminal adluminal NNP cord-028721-x6f26ahr 3098 10 compartment compartment NN cord-028721-x6f26ahr 3098 11 , , , cord-028721-x6f26ahr 3098 12 with with IN cord-028721-x6f26ahr 3098 13 degenerative degenerative JJ cord-028721-x6f26ahr 3098 14 changes change NNS cord-028721-x6f26ahr 3098 15 in in IN cord-028721-x6f26ahr 3098 16 the the DT cord-028721-x6f26ahr 3098 17 apical apical JJ cord-028721-x6f26ahr 3098 18 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3098 19 of of IN cord-028721-x6f26ahr 3098 20 Sertoli sertoli JJ cord-028721-x6f26ahr 3098 21 cells cell NNS cord-028721-x6f26ahr 3098 22 , , , cord-028721-x6f26ahr 3098 23 sloughing slough VBG cord-028721-x6f26ahr 3098 24 of of IN cord-028721-x6f26ahr 3098 25 young young JJ cord-028721-x6f26ahr 3098 26 spermatids spermatid NNS cord-028721-x6f26ahr 3098 27 , , , cord-028721-x6f26ahr 3098 28 1297 1297 CD cord-028721-x6f26ahr 3098 29 and and CC cord-028721-x6f26ahr 3098 30 increased increase VBN cord-028721-x6f26ahr 3098 31 lipid lipid NN cord-028721-x6f26ahr 3098 32 droplets droplet NNS cord-028721-x6f26ahr 3098 33 in in IN cord-028721-x6f26ahr 3098 34 Leydig leydig NN cord-028721-x6f26ahr 3098 35 cells cell NNS cord-028721-x6f26ahr 3098 36 . . . cord-028721-x6f26ahr 3099 1 1299 1299 CD cord-028721-x6f26ahr 3100 1 In in IN cord-028721-x6f26ahr 3100 2 boys boy NNS cord-028721-x6f26ahr 3100 3 , , , cord-028721-x6f26ahr 3100 4 two two CD cord-028721-x6f26ahr 3100 5 different different JJ cord-028721-x6f26ahr 3100 6 conditions condition NNS cord-028721-x6f26ahr 3100 7 associated associate VBN cord-028721-x6f26ahr 3100 8 with with IN cord-028721-x6f26ahr 3100 9 abnormal abnormal JJ cord-028721-x6f26ahr 3100 10 prolactin prolactin NN cord-028721-x6f26ahr 3100 11 secretion secretion NN cord-028721-x6f26ahr 3100 12 have have VBP cord-028721-x6f26ahr 3100 13 been be VBN cord-028721-x6f26ahr 3100 14 reported report VBN cord-028721-x6f26ahr 3100 15 : : : cord-028721-x6f26ahr 3100 16 hyperprolactinemia hyperprolactinemia NNP cord-028721-x6f26ahr 3100 17 , , , cord-028721-x6f26ahr 3100 18 testicular testicular JJ cord-028721-x6f26ahr 3100 19 enlargement enlargement NN cord-028721-x6f26ahr 3100 20 , , , cord-028721-x6f26ahr 3100 21 and and CC cord-028721-x6f26ahr 3100 22 primary primary JJ cord-028721-x6f26ahr 3100 23 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3100 24 ; ; : cord-028721-x6f26ahr 3100 25 and and CC cord-028721-x6f26ahr 3100 26 prolactin prolactin NN cord-028721-x6f26ahr 3100 27 defi defi NNP cord-028721-x6f26ahr 3100 28 ciency ciency NNP cord-028721-x6f26ahr 3100 29 , , , cord-028721-x6f26ahr 3100 30 obesity obesity NN cord-028721-x6f26ahr 3100 31 , , , cord-028721-x6f26ahr 3100 32 and and CC cord-028721-x6f26ahr 3100 33 enlarged enlarged JJ cord-028721-x6f26ahr 3100 34 testes testis NNS cord-028721-x6f26ahr 3100 35 . . . cord-028721-x6f26ahr 3101 1 Infertility infertility NN cord-028721-x6f26ahr 3101 2 caused cause VBN cord-028721-x6f26ahr 3101 3 by by IN cord-028721-x6f26ahr 3101 4 thyroid thyroid NN cord-028721-x6f26ahr 3101 5 gland gland NN cord-028721-x6f26ahr 3101 6 malfunction malfunction NN cord-028721-x6f26ahr 3101 7 is be VBZ cord-028721-x6f26ahr 3101 8 rare rare JJ cord-028721-x6f26ahr 3101 9 but but CC cord-028721-x6f26ahr 3101 10 reversible reversible JJ cord-028721-x6f26ahr 3101 11 . . . cord-028721-x6f26ahr 3102 1 It -PRON- PRP cord-028721-x6f26ahr 3102 2 accounts account VBZ cord-028721-x6f26ahr 3102 3 for for IN cord-028721-x6f26ahr 3102 4 about about RB cord-028721-x6f26ahr 3102 5 0.5 0.5 CD cord-028721-x6f26ahr 3102 6 % % NN cord-028721-x6f26ahr 3102 7 of of IN cord-028721-x6f26ahr 3102 8 male male JJ cord-028721-x6f26ahr 3102 9 infertility infertility NN cord-028721-x6f26ahr 3102 10 Testicular Testicular NNP cord-028721-x6f26ahr 3102 11 function function NN cord-028721-x6f26ahr 3103 1 is be VBZ cord-028721-x6f26ahr 3103 2 impaired impair VBN cord-028721-x6f26ahr 3103 3 more more RBR cord-028721-x6f26ahr 3103 4 by by IN cord-028721-x6f26ahr 3103 5 hypo hypo NN cord-028721-x6f26ahr 3103 6 - - : cord-028721-x6f26ahr 3103 7 than than IN cord-028721-x6f26ahr 3103 8 by by IN cord-028721-x6f26ahr 3103 9 hyperthyroidism hyperthyroidism NN cord-028721-x6f26ahr 3103 10 . . . cord-028721-x6f26ahr 3104 1 Patients patient NNS cord-028721-x6f26ahr 3104 2 with with IN cord-028721-x6f26ahr 3104 3 hyperthyroidism hyperthyroidism NN cord-028721-x6f26ahr 3104 4 may may MD cord-028721-x6f26ahr 3104 5 have have VB cord-028721-x6f26ahr 3104 6 gynecomastia gynecomastia NN cord-028721-x6f26ahr 3104 7 , , , cord-028721-x6f26ahr 3104 8 impotence impotence NN cord-028721-x6f26ahr 3104 9 , , , cord-028721-x6f26ahr 3104 10 and and CC cord-028721-x6f26ahr 3104 11 infertility infertility NN cord-028721-x6f26ahr 3104 12 . . . cord-028721-x6f26ahr 3105 1 Levels level NNS cord-028721-x6f26ahr 3105 2 of of IN cord-028721-x6f26ahr 3105 3 FSH fsh NN cord-028721-x6f26ahr 3105 4 and and CC cord-028721-x6f26ahr 3105 5 LH LH NNP cord-028721-x6f26ahr 3105 6 serum serum NN cord-028721-x6f26ahr 3105 7 are be VBP cord-028721-x6f26ahr 3105 8 normal normal JJ cord-028721-x6f26ahr 3105 9 or or CC cord-028721-x6f26ahr 3105 10 increased increase VBN cord-028721-x6f26ahr 3105 11 , , , cord-028721-x6f26ahr 3105 12 with with IN cord-028721-x6f26ahr 3105 13 elevated elevated JJ cord-028721-x6f26ahr 3105 14 sex sex NN cord-028721-x6f26ahr 3105 15 hormonebinding hormonebinding NN cord-028721-x6f26ahr 3105 16 globulin globulin NN cord-028721-x6f26ahr 3105 17 , , , cord-028721-x6f26ahr 3105 18 increased increase VBD cord-028721-x6f26ahr 3105 19 testosterone testosterone NN cord-028721-x6f26ahr 3105 20 concentration concentration NN cord-028721-x6f26ahr 3105 21 , , , cord-028721-x6f26ahr 3105 22 reduced reduce VBN cord-028721-x6f26ahr 3105 23 non non JJ cord-028721-x6f26ahr 3105 24 - - JJ cord-028721-x6f26ahr 3105 25 sex sex JJ cord-028721-x6f26ahr 3105 26 hormone hormone NN cord-028721-x6f26ahr 3105 27 - - HYPH cord-028721-x6f26ahr 3105 28 binding bind VBG cord-028721-x6f26ahr 3105 29 globulin globulin NN cord-028721-x6f26ahr 3105 30 - - HYPH cord-028721-x6f26ahr 3105 31 bound bind VBN cord-028721-x6f26ahr 3105 32 testosterone testosterone NN cord-028721-x6f26ahr 3105 33 , , , cord-028721-x6f26ahr 3105 34 and and CC cord-028721-x6f26ahr 3105 35 little little JJ cord-028721-x6f26ahr 3105 36 or or CC cord-028721-x6f26ahr 3105 37 no no DT cord-028721-x6f26ahr 3105 38 change change NN cord-028721-x6f26ahr 3105 39 in in IN cord-028721-x6f26ahr 3105 40 free free JJ cord-028721-x6f26ahr 3105 41 testosterone testosterone NN cord-028721-x6f26ahr 3105 42 . . . cord-028721-x6f26ahr 3106 1 1300 1300 CD cord-028721-x6f26ahr 3106 2 , , , cord-028721-x6f26ahr 3106 3 1301 1301 CD cord-028721-x6f26ahr 3107 1 In in IN cord-028721-x6f26ahr 3107 2 Graves Graves NNPS cord-028721-x6f26ahr 3107 3 ' ' POS cord-028721-x6f26ahr 3107 4 disease disease NN cord-028721-x6f26ahr 3107 5 there there EX cord-028721-x6f26ahr 3107 6 is be VBZ cord-028721-x6f26ahr 3107 7 a a DT cord-028721-x6f26ahr 3107 8 pronounced pronounced JJ cord-028721-x6f26ahr 3107 9 inhibition inhibition NN cord-028721-x6f26ahr 3107 10 of of IN cord-028721-x6f26ahr 3107 11 gonadal gonadal JJ cord-028721-x6f26ahr 3107 12 steroidogenesis steroidogenesis NNP cord-028721-x6f26ahr 3107 13 . . . cord-028721-x6f26ahr 3108 1 1302 1302 CD cord-028721-x6f26ahr 3109 1 In in IN cord-028721-x6f26ahr 3109 2 patients patient NNS cord-028721-x6f26ahr 3109 3 with with IN cord-028721-x6f26ahr 3109 4 hyperthyroidism hyperthyroidism NN cord-028721-x6f26ahr 3109 5 , , , cord-028721-x6f26ahr 3109 6 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3109 7 may may MD cord-028721-x6f26ahr 3109 8 be be VB cord-028721-x6f26ahr 3109 9 normal normal JJ cord-028721-x6f26ahr 3109 10 or or CC cord-028721-x6f26ahr 3109 11 reduced reduce VBN cord-028721-x6f26ahr 3109 12 in in IN cord-028721-x6f26ahr 3109 13 number number NN cord-028721-x6f26ahr 3109 14 , , , cord-028721-x6f26ahr 3109 15 and and CC cord-028721-x6f26ahr 3109 16 in in IN cord-028721-x6f26ahr 3109 17 both both DT cord-028721-x6f26ahr 3109 18 cases case NNS cord-028721-x6f26ahr 3109 19 progressive progressive JJ cord-028721-x6f26ahr 3109 20 motility motility NN cord-028721-x6f26ahr 3109 21 is be VBZ cord-028721-x6f26ahr 3109 22 low low JJ cord-028721-x6f26ahr 3109 23 . . . cord-028721-x6f26ahr 3110 1 Prepubertal prepubertal JJ cord-028721-x6f26ahr 3110 2 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3110 3 may may MD cord-028721-x6f26ahr 3110 4 impair impair VB cord-028721-x6f26ahr 3110 5 testicular testicular JJ cord-028721-x6f26ahr 3110 6 function function NN cord-028721-x6f26ahr 3110 7 by by IN cord-028721-x6f26ahr 3110 8 causing cause VBG cord-028721-x6f26ahr 3110 9 precocious precocious JJ cord-028721-x6f26ahr 3110 10 or or CC cord-028721-x6f26ahr 3110 11 delayed delay VBN cord-028721-x6f26ahr 3110 12 puberty puberty NN cord-028721-x6f26ahr 3110 13 . . . cord-028721-x6f26ahr 3111 1 In in IN cord-028721-x6f26ahr 3111 2 delayed delay VBN cord-028721-x6f26ahr 3111 3 puberty puberty NN cord-028721-x6f26ahr 3111 4 , , , cord-028721-x6f26ahr 3111 5 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3111 6 leads lead VBZ cord-028721-x6f26ahr 3111 7 to to IN cord-028721-x6f26ahr 3111 8 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3111 9 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 3111 10 , , , cord-028721-x6f26ahr 3111 11 with with IN cord-028721-x6f26ahr 3111 12 testes testis NNS cord-028721-x6f26ahr 3111 13 showing show VBG cord-028721-x6f26ahr 3111 14 incomplete incomplete JJ cord-028721-x6f26ahr 3111 15 maturation maturation NN cord-028721-x6f26ahr 3111 16 arrest arrest NN cord-028721-x6f26ahr 3111 17 and and CC cord-028721-x6f26ahr 3111 18 , , , cord-028721-x6f26ahr 3111 19 in in IN cord-028721-x6f26ahr 3111 20 severe severe JJ cord-028721-x6f26ahr 3111 21 myxedematous myxedematous JJ cord-028721-x6f26ahr 3111 22 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3111 23 , , , cord-028721-x6f26ahr 3111 24 hydrocele hydrocele NNP cord-028721-x6f26ahr 3111 25 . . . cord-028721-x6f26ahr 3112 1 1303 1303 CD cord-028721-x6f26ahr 3113 1 In in IN cord-028721-x6f26ahr 3113 2 experimental experimental JJ cord-028721-x6f26ahr 3113 3 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3113 4 , , , cord-028721-x6f26ahr 3113 5 testicular testicular JJ cord-028721-x6f26ahr 3113 6 enlargement enlargement NN cord-028721-x6f26ahr 3113 7 is be VBZ cord-028721-x6f26ahr 3113 8 frequently frequently RB cord-028721-x6f26ahr 3113 9 associated associate VBN cord-028721-x6f26ahr 3113 10 with with IN cord-028721-x6f26ahr 3113 11 increased increase VBN cord-028721-x6f26ahr 3113 12 spermatid spermatid JJ cord-028721-x6f26ahr 3113 13 production production NN cord-028721-x6f26ahr 3113 14 . . . cord-028721-x6f26ahr 3114 1 1304 1304 CD cord-028721-x6f26ahr 3114 2 Primary primary JJ cord-028721-x6f26ahr 3114 3 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3114 4 in in IN cord-028721-x6f26ahr 3114 5 adults adult NNS cord-028721-x6f26ahr 3114 6 causes cause VBZ cord-028721-x6f26ahr 3114 7 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 3114 8 , , , cord-028721-x6f26ahr 3114 9 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3114 10 , , , cord-028721-x6f26ahr 3114 11 or or CC cord-028721-x6f26ahr 3114 12 normogonadotropic normogonadotropic NNP cord-028721-x6f26ahr 3114 13 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3114 14 , , , cord-028721-x6f26ahr 3114 15 1305 1305 CD cord-028721-x6f26ahr 3114 16 but but CC cord-028721-x6f26ahr 3114 17 testicular testicular JJ cord-028721-x6f26ahr 3114 18 function function NN cord-028721-x6f26ahr 3114 19 is be VBZ cord-028721-x6f26ahr 3114 20 rarely rarely RB cord-028721-x6f26ahr 3114 21 impaired impaired JJ cord-028721-x6f26ahr 3114 22 and and CC cord-028721-x6f26ahr 3114 23 patients patient NNS cord-028721-x6f26ahr 3114 24 are be VBP cord-028721-x6f26ahr 3114 25 usually usually RB cord-028721-x6f26ahr 3114 26 infertile infertile JJ cord-028721-x6f26ahr 3114 27 . . . cord-028721-x6f26ahr 3115 1 1306 1306 CD cord-028721-x6f26ahr 3116 1 The the DT cord-028721-x6f26ahr 3116 2 cause cause NN cord-028721-x6f26ahr 3116 3 of of IN cord-028721-x6f26ahr 3116 4 testicular testicular JJ cord-028721-x6f26ahr 3116 5 damage damage NN cord-028721-x6f26ahr 3116 6 is be VBZ cord-028721-x6f26ahr 3116 7 decreased decrease VBN cord-028721-x6f26ahr 3116 8 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 3116 9 or or CC cord-028721-x6f26ahr 3116 10 hyperprolactinemia hyperprolactinemia NNP cord-028721-x6f26ahr 3116 11 . . . cord-028721-x6f26ahr 3117 1 1307 1307 CD cord-028721-x6f26ahr 3117 2 Children child NNS cord-028721-x6f26ahr 3117 3 with with IN cord-028721-x6f26ahr 3117 4 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 3117 5 usually usually RB cord-028721-x6f26ahr 3117 6 have have VBP cord-028721-x6f26ahr 3117 7 precocious precocious JJ cord-028721-x6f26ahr 3117 8 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 3117 9 . . . cord-028721-x6f26ahr 3118 1 1308 1308 CD cord-028721-x6f26ahr 3119 1 About about RB cord-028721-x6f26ahr 3119 2 11 11 CD cord-028721-x6f26ahr 3119 3 % % NN cord-028721-x6f26ahr 3119 4 of of IN cord-028721-x6f26ahr 3119 5 infertile infertile JJ cord-028721-x6f26ahr 3119 6 patients patient NNS cord-028721-x6f26ahr 3119 7 reportedly reportedly RB cord-028721-x6f26ahr 3119 8 have have VBP cord-028721-x6f26ahr 3119 9 subclinical subclinical JJ cord-028721-x6f26ahr 3119 10 adrenal adrenal JJ cord-028721-x6f26ahr 3119 11 dysfunction dysfunction NN cord-028721-x6f26ahr 3119 12 , , , cord-028721-x6f26ahr 3119 13 but but CC cord-028721-x6f26ahr 3119 14 the the DT cord-028721-x6f26ahr 3119 15 true true JJ cord-028721-x6f26ahr 3119 16 incidence incidence NN cord-028721-x6f26ahr 3119 17 is be VBZ cord-028721-x6f26ahr 3119 18 probably probably RB cord-028721-x6f26ahr 3119 19 lower low JJR cord-028721-x6f26ahr 3119 20 . . . cord-028721-x6f26ahr 3120 1 Adrenal adrenal JJ cord-028721-x6f26ahr 3120 2 disorders disorder NNS cord-028721-x6f26ahr 3120 3 most most RBS cord-028721-x6f26ahr 3120 4 frequently frequently RB cord-028721-x6f26ahr 3120 5 associated associate VBN cord-028721-x6f26ahr 3120 6 with with IN cord-028721-x6f26ahr 3120 7 infertility infertility NN cord-028721-x6f26ahr 3120 8 are be VBP cord-028721-x6f26ahr 3120 9 adrenal adrenal JJ cord-028721-x6f26ahr 3120 10 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3120 11 , , , cord-028721-x6f26ahr 3120 12 adrenal adrenal JJ cord-028721-x6f26ahr 3120 13 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3120 14 , , , cord-028721-x6f26ahr 3120 15 and and CC cord-028721-x6f26ahr 3120 16 adrenal adrenal JJ cord-028721-x6f26ahr 3120 17 carcinoma carcinoma NN cord-028721-x6f26ahr 3120 18 . . . cord-028721-x6f26ahr 3121 1 Congenital congenital JJ cord-028721-x6f26ahr 3121 2 adrenal adrenal JJ cord-028721-x6f26ahr 3121 3 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3121 4 with with IN cord-028721-x6f26ahr 3121 5 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3121 6 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 3121 7 is be VBZ cord-028721-x6f26ahr 3121 8 an an DT cord-028721-x6f26ahr 3121 9 X x NN cord-028721-x6f26ahr 3121 10 - - HYPH cord-028721-x6f26ahr 3121 11 linked link VBN cord-028721-x6f26ahr 3121 12 recessive recessive JJ cord-028721-x6f26ahr 3121 13 disorder disorder NN cord-028721-x6f26ahr 3121 14 that that WDT cord-028721-x6f26ahr 3121 15 gives give VBZ cord-028721-x6f26ahr 3121 16 rise rise NN cord-028721-x6f26ahr 3121 17 to to IN cord-028721-x6f26ahr 3121 18 adrenal adrenal JJ cord-028721-x6f26ahr 3121 19 insuffi insuffi NNP cord-028721-x6f26ahr 3121 20 ciency ciency NNP cord-028721-x6f26ahr 3121 21 in in IN cord-028721-x6f26ahr 3121 22 the the DT cord-028721-x6f26ahr 3121 23 fi fi NNP cord-028721-x6f26ahr 3121 24 rst rst NNP cord-028721-x6f26ahr 3121 25 months month NNS cord-028721-x6f26ahr 3121 26 of of IN cord-028721-x6f26ahr 3121 27 life life NN cord-028721-x6f26ahr 3121 28 . . . cord-028721-x6f26ahr 3122 1 In in IN cord-028721-x6f26ahr 3122 2 later later JJ cord-028721-x6f26ahr 3122 3 presentations presentation NNS cord-028721-x6f26ahr 3122 4 , , , cord-028721-x6f26ahr 3122 5 patients patient NNS cord-028721-x6f26ahr 3122 6 have have VBP cord-028721-x6f26ahr 3122 7 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3122 8 and and CC cord-028721-x6f26ahr 3122 9 delayed delay VBN cord-028721-x6f26ahr 3122 10 puberty puberty NN cord-028721-x6f26ahr 3122 11 . . . cord-028721-x6f26ahr 3123 1 1309 1309 CD cord-028721-x6f26ahr 3124 1 The the DT cord-028721-x6f26ahr 3124 2 responsible responsible JJ cord-028721-x6f26ahr 3124 3 gene gene NN cord-028721-x6f26ahr 3124 4 , , , cord-028721-x6f26ahr 3124 5 DAX1 DAX1 NNP cord-028721-x6f26ahr 3124 6 on on IN cord-028721-x6f26ahr 3124 7 Xp21 Xp21 NNP cord-028721-x6f26ahr 3124 8 , , , cord-028721-x6f26ahr 3124 9 is be VBZ cord-028721-x6f26ahr 3124 10 expressed express VBN cord-028721-x6f26ahr 3124 11 in in IN cord-028721-x6f26ahr 3124 12 the the DT cord-028721-x6f26ahr 3124 13 adrenals adrenal NNS cord-028721-x6f26ahr 3124 14 , , , cord-028721-x6f26ahr 3124 15 testes testis NNS cord-028721-x6f26ahr 3124 16 , , , cord-028721-x6f26ahr 3124 17 pituitary pituitary NN cord-028721-x6f26ahr 3124 18 , , , cord-028721-x6f26ahr 3124 19 and and CC cord-028721-x6f26ahr 3124 20 hypothalamus hypothalamus NN cord-028721-x6f26ahr 3124 21 . . . cord-028721-x6f26ahr 3125 1 The the DT cord-028721-x6f26ahr 3125 2 resulting result VBG cord-028721-x6f26ahr 3125 3 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3125 4 may may MD cord-028721-x6f26ahr 3125 5 be be VB cord-028721-x6f26ahr 3125 6 either either CC cord-028721-x6f26ahr 3125 7 pure pure JJ cord-028721-x6f26ahr 3125 8 or or CC cord-028721-x6f26ahr 3125 9 mixed mixed JJ cord-028721-x6f26ahr 3125 10 ( ( -LRB- cord-028721-x6f26ahr 3125 11 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 3125 12 and and CC cord-028721-x6f26ahr 3125 13 testicular testicular NNP cord-028721-x6f26ahr 3125 14 ) ) -RRB- cord-028721-x6f26ahr 3125 15 . . . cord-028721-x6f26ahr 3126 1 In in IN cord-028721-x6f26ahr 3126 2 the the DT cord-028721-x6f26ahr 3126 3 last last JJ cord-028721-x6f26ahr 3126 4 case case NN cord-028721-x6f26ahr 3126 5 , , , cord-028721-x6f26ahr 3126 6 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3126 7 is be VBZ cord-028721-x6f26ahr 3126 8 partial partial JJ cord-028721-x6f26ahr 3126 9 . . . cord-028721-x6f26ahr 3127 1 1310 1310 CD cord-028721-x6f26ahr 3127 2 Testicular Testicular NNP cord-028721-x6f26ahr 3127 3 biopsy biopsy NN cord-028721-x6f26ahr 3127 4 from from IN cord-028721-x6f26ahr 3127 5 one one CD cord-028721-x6f26ahr 3127 6 adult adult NN cord-028721-x6f26ahr 3127 7 with with IN cord-028721-x6f26ahr 3127 8 adrenal adrenal JJ cord-028721-x6f26ahr 3127 9 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3127 10 showed show VBD cord-028721-x6f26ahr 3127 11 an an DT cord-028721-x6f26ahr 3127 12 apparent apparent JJ cord-028721-x6f26ahr 3127 13 primary primary JJ cord-028721-x6f26ahr 3127 14 lesion lesion NN cord-028721-x6f26ahr 3127 15 , , , cord-028721-x6f26ahr 3127 16 including include VBG cord-028721-x6f26ahr 3127 17 tubules tubule NNS cord-028721-x6f26ahr 3127 18 with with IN cord-028721-x6f26ahr 3127 19 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 3127 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 3127 21 cells cell NNS cord-028721-x6f26ahr 3127 22 and and CC cord-028721-x6f26ahr 3127 23 others other NNS cord-028721-x6f26ahr 3127 24 with with IN cord-028721-x6f26ahr 3127 25 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 3127 26 maturation maturation NN cord-028721-x6f26ahr 3127 27 arrest arrest NN cord-028721-x6f26ahr 3127 28 in in IN cord-028721-x6f26ahr 3127 29 associated associate VBN cord-028721-x6f26ahr 3127 30 with with IN cord-028721-x6f26ahr 3127 31 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3127 32 and and CC cord-028721-x6f26ahr 3127 33 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3127 34 of of IN cord-028721-x6f26ahr 3127 35 Leydig Leydig NNP cord-028721-x6f26ahr 3127 36 cells cell NNS cord-028721-x6f26ahr 3127 37 . . . cord-028721-x6f26ahr 3128 1 1311 1311 CD cord-028721-x6f26ahr 3128 2 _SP cord-028721-x6f26ahr 3129 1 Infertility infertility NN cord-028721-x6f26ahr 3129 2 is be VBZ cord-028721-x6f26ahr 3129 3 frequent frequent JJ cord-028721-x6f26ahr 3129 4 in in IN cord-028721-x6f26ahr 3129 5 patients patient NNS cord-028721-x6f26ahr 3129 6 with with IN cord-028721-x6f26ahr 3129 7 minor minor JJ cord-028721-x6f26ahr 3129 8 forms form NNS cord-028721-x6f26ahr 3129 9 of of IN cord-028721-x6f26ahr 3129 10 congenital congenital JJ cord-028721-x6f26ahr 3129 11 adrenal adrenal JJ cord-028721-x6f26ahr 3129 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3129 13 . . . cord-028721-x6f26ahr 3130 1 Those those DT cord-028721-x6f26ahr 3130 2 with with IN cord-028721-x6f26ahr 3130 3 defi defi NNP cord-028721-x6f26ahr 3130 4 ciency ciency NN cord-028721-x6f26ahr 3130 5 of of IN cord-028721-x6f26ahr 3130 6 21hydroxylase 21hydroxylase CD cord-028721-x6f26ahr 3130 7 1312 1312 CD cord-028721-x6f26ahr 3130 8 or or CC cord-028721-x6f26ahr 3130 9 11β 11β NNS cord-028721-x6f26ahr 3130 10 - - : cord-028721-x6f26ahr 3130 11 hydroxylase hydroxylase NN cord-028721-x6f26ahr 3130 12 usually usually RB cord-028721-x6f26ahr 3130 13 have have VBP cord-028721-x6f26ahr 3130 14 complete complete JJ cord-028721-x6f26ahr 3130 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3130 16 but but CC cord-028721-x6f26ahr 3130 17 with with IN cord-028721-x6f26ahr 3130 18 reduced reduced JJ cord-028721-x6f26ahr 3130 19 numbers number NNS cord-028721-x6f26ahr 3130 20 of of IN cord-028721-x6f26ahr 3130 21 all all DT cord-028721-x6f26ahr 3130 22 germ germ NN cord-028721-x6f26ahr 3130 23 cells cell NNS cord-028721-x6f26ahr 3130 24 . . . cord-028721-x6f26ahr 3131 1 The the DT cord-028721-x6f26ahr 3131 2 characteristic characteristic JJ cord-028721-x6f26ahr 3131 3 histologic histologic NN cord-028721-x6f26ahr 3131 4 fi fi NN cord-028721-x6f26ahr 3131 5 nding nding NN cord-028721-x6f26ahr 3131 6 is be VBZ cord-028721-x6f26ahr 3131 7 decreased decrease VBN cord-028721-x6f26ahr 3131 8 numbers number NNS cord-028721-x6f26ahr 3131 9 of of IN cord-028721-x6f26ahr 3131 10 Leydig Leydig NNP cord-028721-x6f26ahr 3131 11 cells cell NNS cord-028721-x6f26ahr 3131 12 . . . cord-028721-x6f26ahr 3132 1 [ [ -LRB- cord-028721-x6f26ahr 3132 2 1313 1313 CD cord-028721-x6f26ahr 3132 3 ] ] -RRB- cord-028721-x6f26ahr 3132 4 [ [ -LRB- cord-028721-x6f26ahr 3132 5 1314 1314 CD cord-028721-x6f26ahr 3132 6 ] ] -RRB- cord-028721-x6f26ahr 3133 1 [ [ -LRB- cord-028721-x6f26ahr 3133 2 1315 1315 CD cord-028721-x6f26ahr 3133 3 ] ] -RRB- cord-028721-x6f26ahr 3133 4 [ [ -LRB- cord-028721-x6f26ahr 3133 5 1316 1316 CD cord-028721-x6f26ahr 3133 6 ] ] -RRB- cord-028721-x6f26ahr 3134 1 In in IN cord-028721-x6f26ahr 3134 2 untreated untreated JJ cord-028721-x6f26ahr 3134 3 patients patient NNS cord-028721-x6f26ahr 3134 4 , , , cord-028721-x6f26ahr 3134 5 the the DT cord-028721-x6f26ahr 3134 6 testes testis NNS cord-028721-x6f26ahr 3134 7 become become VBP cord-028721-x6f26ahr 3134 8 enlarged enlarge VBN cord-028721-x6f26ahr 3134 9 by by IN cord-028721-x6f26ahr 3134 10 ' ' `` cord-028721-x6f26ahr 3134 11 tumors tumor NNS cord-028721-x6f26ahr 3134 12 ' ' '' cord-028721-x6f26ahr 3134 13 of of IN cord-028721-x6f26ahr 3134 14 the the DT cord-028721-x6f26ahr 3134 15 adrenogenital adrenogenital JJ cord-028721-x6f26ahr 3134 16 syndrome syndrome NN cord-028721-x6f26ahr 3134 17 that that WDT cord-028721-x6f26ahr 3134 18 consist consist VBP cord-028721-x6f26ahr 3134 19 of of IN cord-028721-x6f26ahr 3134 20 cells cell NNS cord-028721-x6f26ahr 3134 21 similar similar JJ cord-028721-x6f26ahr 3134 22 to to IN cord-028721-x6f26ahr 3134 23 adrenal adrenal JJ cord-028721-x6f26ahr 3134 24 cortical cortical JJ cord-028721-x6f26ahr 3134 25 cells cell NNS cord-028721-x6f26ahr 3134 26 ( ( -LRB- cord-028721-x6f26ahr 3134 27 Fig fig NN cord-028721-x6f26ahr 3134 28 . . . cord-028721-x6f26ahr 3134 29 _SP cord-028721-x6f26ahr 3135 1 12 12 CD cord-028721-x6f26ahr 3135 2 - - SYM cord-028721-x6f26ahr 3135 3 142 142 CD cord-028721-x6f26ahr 3135 4 ) ) -RRB- cord-028721-x6f26ahr 3135 5 . . . cord-028721-x6f26ahr 3136 1 [ [ -LRB- cord-028721-x6f26ahr 3136 2 1316 1316 CD cord-028721-x6f26ahr 3136 3 ] ] -RRB- cord-028721-x6f26ahr 3136 4 [ [ -LRB- cord-028721-x6f26ahr 3136 5 1317 1317 CD cord-028721-x6f26ahr 3136 6 ] ] -RRB- cord-028721-x6f26ahr 3136 7 [ [ -LRB- cord-028721-x6f26ahr 3136 8 1318 1318 CD cord-028721-x6f26ahr 3136 9 ] ] -RRB- cord-028721-x6f26ahr 3137 1 [ [ -LRB- cord-028721-x6f26ahr 3137 2 1319 1319 CD cord-028721-x6f26ahr 3137 3 ] ] -RRB- cord-028721-x6f26ahr 3138 1 Adrenal adrenal JJ cord-028721-x6f26ahr 3138 2 cortical cortical JJ cord-028721-x6f26ahr 3138 3 carcinoma carcinoma NN cord-028721-x6f26ahr 3138 4 Adrenal adrenal JJ cord-028721-x6f26ahr 3138 5 carcinoma carcinoma NN cord-028721-x6f26ahr 3138 6 is be VBZ cord-028721-x6f26ahr 3138 7 often often RB cord-028721-x6f26ahr 3138 8 associated associate VBN cord-028721-x6f26ahr 3138 9 with with IN cord-028721-x6f26ahr 3138 10 excessive excessive JJ cord-028721-x6f26ahr 3138 11 secretion secretion NN cord-028721-x6f26ahr 3138 12 of of IN cord-028721-x6f26ahr 3138 13 several several JJ cord-028721-x6f26ahr 3138 14 hormones hormone NNS cord-028721-x6f26ahr 3138 15 , , , cord-028721-x6f26ahr 3138 16 causing cause VBG cord-028721-x6f26ahr 3138 17 hyperaldosteronism hyperaldosteronism NN cord-028721-x6f26ahr 3138 18 , , , cord-028721-x6f26ahr 3138 19 Cushing Cushing NNP cord-028721-x6f26ahr 3138 20 's 's POS cord-028721-x6f26ahr 3138 21 syndrome syndrome NN cord-028721-x6f26ahr 3138 22 , , , cord-028721-x6f26ahr 3138 23 virilization virilization NN cord-028721-x6f26ahr 3138 24 , , , cord-028721-x6f26ahr 3138 25 or or CC cord-028721-x6f26ahr 3138 26 feminization feminization NN cord-028721-x6f26ahr 3138 27 . . . cord-028721-x6f26ahr 3139 1 Virilizing virilize VBG cord-028721-x6f26ahr 3139 2 tumors tumor NNS cord-028721-x6f26ahr 3139 3 in in IN cord-028721-x6f26ahr 3139 4 infancy infancy NN cord-028721-x6f26ahr 3139 5 have have VBP cord-028721-x6f26ahr 3139 6 their -PRON- PRP$ cord-028721-x6f26ahr 3139 7 own own JJ cord-028721-x6f26ahr 3139 8 characteristics characteristic NNS cord-028721-x6f26ahr 3139 9 , , , cord-028721-x6f26ahr 3139 10 which which WDT cord-028721-x6f26ahr 3139 11 differ differ VBP cord-028721-x6f26ahr 3139 12 from from IN cord-028721-x6f26ahr 3139 13 those those DT cord-028721-x6f26ahr 3139 14 of of IN cord-028721-x6f26ahr 3139 15 the the DT cord-028721-x6f26ahr 3139 16 same same JJ cord-028721-x6f26ahr 3139 17 adult adult NN cord-028721-x6f26ahr 3139 18 tumors tumor NNS cord-028721-x6f26ahr 3139 19 as as IN cord-028721-x6f26ahr 3139 20 the the DT cord-028721-x6f26ahr 3139 21 infantile infantile JJ cord-028721-x6f26ahr 3139 22 form form NN cord-028721-x6f26ahr 3139 23 may may MD cord-028721-x6f26ahr 3139 24 be be VB cord-028721-x6f26ahr 3139 25 associated associate VBN cord-028721-x6f26ahr 3139 26 with with IN cord-028721-x6f26ahr 3139 27 other other JJ cord-028721-x6f26ahr 3139 28 disorders disorder NNS cord-028721-x6f26ahr 3139 29 , , , cord-028721-x6f26ahr 3139 30 such such JJ cord-028721-x6f26ahr 3139 31 as as IN cord-028721-x6f26ahr 3139 32 hemihypertrophy hemihypertrophy NNP cord-028721-x6f26ahr 3139 33 and and CC cord-028721-x6f26ahr 3139 34 Beckwith Beckwith NNP cord-028721-x6f26ahr 3139 35 - - HYPH cord-028721-x6f26ahr 3139 36 Wiederman Wiederman NNP cord-028721-x6f26ahr 3139 37 syndrome syndrome NN cord-028721-x6f26ahr 3139 38 , , , cord-028721-x6f26ahr 3139 39 may may MD cord-028721-x6f26ahr 3139 40 be be VB cord-028721-x6f26ahr 3139 41 included include VBN cord-028721-x6f26ahr 3139 42 in in IN cord-028721-x6f26ahr 3139 43 the the DT cord-028721-x6f26ahr 3139 44 spectrum spectrum NN cord-028721-x6f26ahr 3139 45 of of IN cord-028721-x6f26ahr 3139 46 ' ' `` cord-028721-x6f26ahr 3139 47 families family NNS cord-028721-x6f26ahr 3139 48 with with IN cord-028721-x6f26ahr 3139 49 cancer cancer NN cord-028721-x6f26ahr 3139 50 predisposition predisposition NN cord-028721-x6f26ahr 3139 51 ' ' '' cord-028721-x6f26ahr 3139 52 ( ( -LRB- cord-028721-x6f26ahr 3139 53 mutations mutation NNS cord-028721-x6f26ahr 3139 54 in in IN cord-028721-x6f26ahr 3139 55 p53 p53 NN cord-028721-x6f26ahr 3139 56 gene gene NN cord-028721-x6f26ahr 3139 57 ) ) -RRB- cord-028721-x6f26ahr 3139 58 , , , cord-028721-x6f26ahr 3139 59 and and CC cord-028721-x6f26ahr 3139 60 produce produce VB cord-028721-x6f26ahr 3139 61 precocious precocious JJ cord-028721-x6f26ahr 3139 62 pseudopuberty pseudopuberty NN cord-028721-x6f26ahr 3139 63 syndrome syndrome NN cord-028721-x6f26ahr 3139 64 . . . cord-028721-x6f26ahr 3140 1 In in IN cord-028721-x6f26ahr 3140 2 adults adult NNS cord-028721-x6f26ahr 3140 3 , , , cord-028721-x6f26ahr 3140 4 adrenal adrenal JJ cord-028721-x6f26ahr 3140 5 carcinoma carcinoma NN cord-028721-x6f26ahr 3140 6 may may MD cord-028721-x6f26ahr 3140 7 cause cause VB cord-028721-x6f26ahr 3140 8 marked mark VBN cord-028721-x6f26ahr 3140 9 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 3140 10 depletion depletion NN cord-028721-x6f26ahr 3140 11 owing owe VBG cord-028721-x6f26ahr 3140 12 to to IN cord-028721-x6f26ahr 3140 13 the the DT cord-028721-x6f26ahr 3140 14 conversion conversion NN cord-028721-x6f26ahr 3140 15 of of IN cord-028721-x6f26ahr 3140 16 large large JJ cord-028721-x6f26ahr 3140 17 amounts amount NNS cord-028721-x6f26ahr 3140 18 of of IN cord-028721-x6f26ahr 3140 19 dehydroepiandrosterone dehydroepiandrosterone NN cord-028721-x6f26ahr 3140 20 produced produce VBN cord-028721-x6f26ahr 3140 21 by by IN cord-028721-x6f26ahr 3140 22 the the DT cord-028721-x6f26ahr 3140 23 tumor tumor NN cord-028721-x6f26ahr 3140 24 into into IN cord-028721-x6f26ahr 3140 25 estrogen estrogen NN cord-028721-x6f26ahr 3140 26 . . . cord-028721-x6f26ahr 3141 1 Feminizing feminize VBG cord-028721-x6f26ahr 3141 2 tumor tumor NN cord-028721-x6f26ahr 3141 3 in in IN cord-028721-x6f26ahr 3141 4 infancy infancy NN cord-028721-x6f26ahr 3141 5 causes cause VBZ cord-028721-x6f26ahr 3141 6 gynecomastia gynecomastia NN cord-028721-x6f26ahr 3141 7 and and CC cord-028721-x6f26ahr 3141 8 pubic pubic NN cord-028721-x6f26ahr 3141 9 hair hair NN cord-028721-x6f26ahr 3141 10 development development NN cord-028721-x6f26ahr 3141 11 . . . cord-028721-x6f26ahr 3142 1 1320 1320 CD cord-028721-x6f26ahr 3143 1 Feminizing feminize VBG cord-028721-x6f26ahr 3143 2 tumor tumor NN cord-028721-x6f26ahr 3143 3 presents present VBZ cord-028721-x6f26ahr 3143 4 more more RBR cord-028721-x6f26ahr 3143 5 striking striking JJ cord-028721-x6f26ahr 3143 6 clinical clinical JJ cord-028721-x6f26ahr 3143 7 characteristics characteristic NNS cord-028721-x6f26ahr 3143 8 , , , cord-028721-x6f26ahr 3143 9 including include VBG cord-028721-x6f26ahr 3143 10 progressive progressive JJ cord-028721-x6f26ahr 3143 11 loss loss NN cord-028721-x6f26ahr 3143 12 of of IN cord-028721-x6f26ahr 3143 13 secondary secondary JJ cord-028721-x6f26ahr 3143 14 sex sex NN cord-028721-x6f26ahr 3143 15 characteristics characteristic NNS cord-028721-x6f26ahr 3143 16 and and CC cord-028721-x6f26ahr 3143 17 feminization feminization NN cord-028721-x6f26ahr 3143 18 due due IN cord-028721-x6f26ahr 3143 19 to to IN cord-028721-x6f26ahr 3143 20 elevated elevated JJ cord-028721-x6f26ahr 3143 21 estrogen estrogen NN cord-028721-x6f26ahr 3143 22 . . . cord-028721-x6f26ahr 3144 1 Testicular testicular JJ cord-028721-x6f26ahr 3144 2 atrophy atrophy NN cord-028721-x6f26ahr 3144 3 results result NNS cord-028721-x6f26ahr 3144 4 from from IN cord-028721-x6f26ahr 3144 5 the the DT cord-028721-x6f26ahr 3144 6 inhibitory inhibitory JJ cord-028721-x6f26ahr 3144 7 effect effect NN cord-028721-x6f26ahr 3144 8 of of IN cord-028721-x6f26ahr 3144 9 estrogen estrogen NN cord-028721-x6f26ahr 3144 10 on on IN cord-028721-x6f26ahr 3144 11 pituitary pituitary JJ cord-028721-x6f26ahr 3144 12 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 3144 13 . . . cord-028721-x6f26ahr 3145 1 Similar similar JJ cord-028721-x6f26ahr 3145 2 symptoms symptom NNS cord-028721-x6f26ahr 3145 3 may may MD cord-028721-x6f26ahr 3145 4 be be VB cord-028721-x6f26ahr 3145 5 observed observe VBN cord-028721-x6f26ahr 3145 6 in in IN cord-028721-x6f26ahr 3145 7 patients patient NNS cord-028721-x6f26ahr 3145 8 with with IN cord-028721-x6f26ahr 3145 9 prostatic prostatic JJ cord-028721-x6f26ahr 3145 10 carcinoma carcinoma NN cord-028721-x6f26ahr 3145 11 treated treat VBN cord-028721-x6f26ahr 3145 12 with with IN cord-028721-x6f26ahr 3145 13 estrogens estrogen NNS cord-028721-x6f26ahr 3145 14 ( ( -LRB- cord-028721-x6f26ahr 3145 15 Fig fig NN cord-028721-x6f26ahr 3145 16 . . . cord-028721-x6f26ahr 3145 17 _SP cord-028721-x6f26ahr 3146 1 12 12 CD cord-028721-x6f26ahr 3146 2 - - SYM cord-028721-x6f26ahr 3146 3 143 143 CD cord-028721-x6f26ahr 3146 4 ) ) -RRB- cord-028721-x6f26ahr 3147 1 and and CC cord-028721-x6f26ahr 3147 2 in in IN cord-028721-x6f26ahr 3147 3 other other JJ cord-028721-x6f26ahr 3147 4 conditions condition NNS cord-028721-x6f26ahr 3147 5 with with IN cord-028721-x6f26ahr 3147 6 excessive excessive JJ cord-028721-x6f26ahr 3147 7 estrogen estrogen NN cord-028721-x6f26ahr 3147 8 production production NN cord-028721-x6f26ahr 3147 9 , , , cord-028721-x6f26ahr 3147 10 such such JJ cord-028721-x6f26ahr 3147 11 as as IN cord-028721-x6f26ahr 3147 12 Sertoli sertoli JJ cord-028721-x6f26ahr 3147 13 cell cell NN cord-028721-x6f26ahr 3147 14 or or CC cord-028721-x6f26ahr 3147 15 Leydig Leydig NNP cord-028721-x6f26ahr 3147 16 cell cell NN cord-028721-x6f26ahr 3147 17 tumor tumor NN cord-028721-x6f26ahr 3147 18 . . . cord-028721-x6f26ahr 3148 1 Patients patient NNS cord-028721-x6f26ahr 3148 2 with with IN cord-028721-x6f26ahr 3148 3 Cushing Cushing NNP cord-028721-x6f26ahr 3148 4 's 's POS cord-028721-x6f26ahr 3148 5 syndrome syndrome NN cord-028721-x6f26ahr 3148 6 or or CC cord-028721-x6f26ahr 3148 7 diseases disease NNS cord-028721-x6f26ahr 3148 8 that that WDT cord-028721-x6f26ahr 3148 9 require require VBP cord-028721-x6f26ahr 3148 10 long long JJ cord-028721-x6f26ahr 3148 11 - - HYPH cord-028721-x6f26ahr 3148 12 term term NN cord-028721-x6f26ahr 3148 13 corticoid corticoid NN cord-028721-x6f26ahr 3148 14 therapy therapy NN cord-028721-x6f26ahr 3148 15 , , , cord-028721-x6f26ahr 3148 16 such such JJ cord-028721-x6f26ahr 3148 17 as as IN cord-028721-x6f26ahr 3148 18 ulcerous ulcerous JJ cord-028721-x6f26ahr 3148 19 colitis colitis NN cord-028721-x6f26ahr 3148 20 , , , cord-028721-x6f26ahr 3148 21 rheumatoid rheumatoid NN cord-028721-x6f26ahr 3148 22 arthritis arthritis NN cord-028721-x6f26ahr 3148 23 , , , cord-028721-x6f26ahr 3148 24 or or CC cord-028721-x6f26ahr 3148 25 asthma asthma NN cord-028721-x6f26ahr 3148 26 , , , cord-028721-x6f26ahr 3148 27 have have VBP cord-028721-x6f26ahr 3148 28 reversible reversible JJ cord-028721-x6f26ahr 3148 29 reduction reduction NN cord-028721-x6f26ahr 3148 30 of of IN cord-028721-x6f26ahr 3148 31 fertility fertility NN cord-028721-x6f26ahr 3148 32 . . . cord-028721-x6f26ahr 3149 1 The the DT cord-028721-x6f26ahr 3149 2 explanation explanation NN cord-028721-x6f26ahr 3149 3 for for IN cord-028721-x6f26ahr 3149 4 this this DT cord-028721-x6f26ahr 3149 5 is be VBZ cord-028721-x6f26ahr 3149 6 that that IN cord-028721-x6f26ahr 3149 7 most most JJS cord-028721-x6f26ahr 3149 8 testicular testicular JJ cord-028721-x6f26ahr 3149 9 receptors receptor NNS cord-028721-x6f26ahr 3149 10 for for IN cord-028721-x6f26ahr 3149 11 corticoids corticoid NNS cord-028721-x6f26ahr 3149 12 are be VBP cord-028721-x6f26ahr 3149 13 in in IN cord-028721-x6f26ahr 3149 14 Leydig Leydig NNP cord-028721-x6f26ahr 3149 15 cells cell NNS cord-028721-x6f26ahr 3149 16 , , , cord-028721-x6f26ahr 3149 17 and and CC cord-028721-x6f26ahr 3149 18 thus thus RB cord-028721-x6f26ahr 3149 19 glucocorticoids glucocorticoid NNS cord-028721-x6f26ahr 3149 20 are be VBP cord-028721-x6f26ahr 3149 21 powerful powerful JJ cord-028721-x6f26ahr 3149 22 inhibitors inhibitor NNS cord-028721-x6f26ahr 3149 23 of of IN cord-028721-x6f26ahr 3149 24 testosterone testosterone NN cord-028721-x6f26ahr 3149 25 synthesis synthesis NN cord-028721-x6f26ahr 3149 26 . . . cord-028721-x6f26ahr 3150 1 Alterations alteration NNS cord-028721-x6f26ahr 3150 2 in in IN cord-028721-x6f26ahr 3150 3 the the DT cord-028721-x6f26ahr 3150 4 carbohydrate carbohydrate NN cord-028721-x6f26ahr 3150 5 , , , cord-028721-x6f26ahr 3150 6 lipid lipid NN cord-028721-x6f26ahr 3150 7 and and CC cord-028721-x6f26ahr 3150 8 protein protein NN cord-028721-x6f26ahr 3150 9 metabolism metabolism NN cord-028721-x6f26ahr 3150 10 characteristic characteristic NN cord-028721-x6f26ahr 3150 11 of of IN cord-028721-x6f26ahr 3150 12 diabetes diabetes NN cord-028721-x6f26ahr 3150 13 mellitus mellitus NN cord-028721-x6f26ahr 3150 14 involve involve VBP cord-028721-x6f26ahr 3150 15 the the DT cord-028721-x6f26ahr 3150 16 genital genital JJ cord-028721-x6f26ahr 3150 17 system system NN cord-028721-x6f26ahr 3150 18 , , , cord-028721-x6f26ahr 3150 19 although although IN cord-028721-x6f26ahr 3150 20 most most JJS cord-028721-x6f26ahr 3150 21 diabetic diabetic JJ cord-028721-x6f26ahr 3150 22 patients patient NNS cord-028721-x6f26ahr 3150 23 are be VBP cord-028721-x6f26ahr 3150 24 fertile fertile JJ cord-028721-x6f26ahr 3150 25 . . . cord-028721-x6f26ahr 3151 1 Gonadal gonadal JJ cord-028721-x6f26ahr 3151 2 impairment impairment NN cord-028721-x6f26ahr 3151 3 depends depend VBZ cord-028721-x6f26ahr 3151 4 on on IN cord-028721-x6f26ahr 3151 5 the the DT cord-028721-x6f26ahr 3151 6 type type NN cord-028721-x6f26ahr 3151 7 of of IN cord-028721-x6f26ahr 3151 8 diabetes diabetes NN cord-028721-x6f26ahr 3151 9 and and CC cord-028721-x6f26ahr 3151 10 the the DT cord-028721-x6f26ahr 3151 11 time time NN cord-028721-x6f26ahr 3151 12 of of IN cord-028721-x6f26ahr 3151 13 disease disease NN cord-028721-x6f26ahr 3151 14 onset onset NN cord-028721-x6f26ahr 3151 15 ( ( -LRB- cord-028721-x6f26ahr 3151 16 infancy infancy NN cord-028721-x6f26ahr 3151 17 and and CC cord-028721-x6f26ahr 3151 18 childhood childhood NN cord-028721-x6f26ahr 3151 19 , , , cord-028721-x6f26ahr 3151 20 puberty puberty NN cord-028721-x6f26ahr 3151 21 , , , cord-028721-x6f26ahr 3151 22 or or CC cord-028721-x6f26ahr 3151 23 adulthood adulthood NN cord-028721-x6f26ahr 3151 24 ) ) -RRB- cord-028721-x6f26ahr 3151 25 . . . cord-028721-x6f26ahr 3152 1 1321 1321 CD cord-028721-x6f26ahr 3152 2 , , , cord-028721-x6f26ahr 3152 3 1322 1322 CD cord-028721-x6f26ahr 3152 4 Testicular testicular JJ cord-028721-x6f26ahr 3152 5 lesions lesion NNS cord-028721-x6f26ahr 3152 6 in in IN cord-028721-x6f26ahr 3152 7 newborns newborn NNS cord-028721-x6f26ahr 3152 8 with with IN cord-028721-x6f26ahr 3152 9 diabetic diabetic JJ cord-028721-x6f26ahr 3152 10 mothers mother NNS cord-028721-x6f26ahr 3152 11 are be VBP cord-028721-x6f26ahr 3152 12 discussed discuss VBN cord-028721-x6f26ahr 3152 13 in in IN cord-028721-x6f26ahr 3152 14 the the DT cord-028721-x6f26ahr 3152 15 section section NN cord-028721-x6f26ahr 3152 16 on on IN cord-028721-x6f26ahr 3152 17 congenital congenital JJ cord-028721-x6f26ahr 3152 18 anomalies anomaly NNS cord-028721-x6f26ahr 3152 19 of of IN cord-028721-x6f26ahr 3152 20 the the DT cord-028721-x6f26ahr 3152 21 testis testis NN cord-028721-x6f26ahr 3152 22 . . . cord-028721-x6f26ahr 3153 1 317 317 CD cord-028721-x6f26ahr 3153 2 Puberty Puberty NNP cord-028721-x6f26ahr 3153 3 may may MD cord-028721-x6f26ahr 3153 4 be be VB cord-028721-x6f26ahr 3153 5 delayed delay VBN cord-028721-x6f26ahr 3153 6 in in IN cord-028721-x6f26ahr 3153 7 diabetic diabetic JJ cord-028721-x6f26ahr 3153 8 patients patient NNS cord-028721-x6f26ahr 3153 9 , , , cord-028721-x6f26ahr 3153 10 although although IN cord-028721-x6f26ahr 3153 11 the the DT cord-028721-x6f26ahr 3153 12 cause cause NN cord-028721-x6f26ahr 3153 13 is be VBZ cord-028721-x6f26ahr 3153 14 unknown unknown JJ cord-028721-x6f26ahr 3153 15 . . . cord-028721-x6f26ahr 3154 1 Other other JJ cord-028721-x6f26ahr 3154 2 gonadal gonadal JJ cord-028721-x6f26ahr 3154 3 alterations alteration NNS cord-028721-x6f26ahr 3154 4 appear appear VBP cord-028721-x6f26ahr 3154 5 at at IN cord-028721-x6f26ahr 3154 6 puberty puberty NN cord-028721-x6f26ahr 3154 7 , , , cord-028721-x6f26ahr 3154 8 and and CC cord-028721-x6f26ahr 3154 9 diabetic diabetic JJ cord-028721-x6f26ahr 3154 10 men man NNS cord-028721-x6f26ahr 3154 11 who who WP cord-028721-x6f26ahr 3154 12 have have VBP cord-028721-x6f26ahr 3154 13 not not RB cord-028721-x6f26ahr 3154 14 been be VBN cord-028721-x6f26ahr 3154 15 adequately adequately RB cord-028721-x6f26ahr 3154 16 treated treat VBN cord-028721-x6f26ahr 3154 17 may may MD cord-028721-x6f26ahr 3154 18 be be VB cord-028721-x6f26ahr 3154 19 infertile infertile JJ cord-028721-x6f26ahr 3154 20 and and CC cord-028721-x6f26ahr 3154 21 have have VB cord-028721-x6f26ahr 3154 22 sexual sexual JJ cord-028721-x6f26ahr 3154 23 dysfunction dysfunction NN cord-028721-x6f26ahr 3154 24 . . . cord-028721-x6f26ahr 3155 1 Serum serum NN cord-028721-x6f26ahr 3155 2 levels level NNS cord-028721-x6f26ahr 3155 3 of of IN cord-028721-x6f26ahr 3155 4 FSH fsh NN cord-028721-x6f26ahr 3155 5 , , , cord-028721-x6f26ahr 3155 6 LH LH NNP cord-028721-x6f26ahr 3155 7 , , , cord-028721-x6f26ahr 3155 8 and and CC cord-028721-x6f26ahr 3155 9 testosterone testosterone NN cord-028721-x6f26ahr 3155 10 are be VBP cord-028721-x6f26ahr 3155 11 decreased decrease VBN cord-028721-x6f26ahr 3155 12 . . . cord-028721-x6f26ahr 3156 1 1323 1323 CD cord-028721-x6f26ahr 3157 1 Spermiograms spermiogram NNS cord-028721-x6f26ahr 3157 2 reveal reveal VBP cord-028721-x6f26ahr 3157 3 low low JJ cord-028721-x6f26ahr 3157 4 numbers number NNS cord-028721-x6f26ahr 3157 5 and and CC cord-028721-x6f26ahr 3157 6 poor poor JJ cord-028721-x6f26ahr 3157 7 motility motility NN cord-028721-x6f26ahr 3157 8 of of IN cord-028721-x6f26ahr 3157 9 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3157 10 . . . cord-028721-x6f26ahr 3158 1 1324 1324 CD cord-028721-x6f26ahr 3158 2 Prolactin prolactin NN cord-028721-x6f26ahr 3158 3 levels level NNS cord-028721-x6f26ahr 3158 4 are be VBP cord-028721-x6f26ahr 3158 5 increased increase VBN cord-028721-x6f26ahr 3158 6 and and CC cord-028721-x6f26ahr 3158 7 testosterone testosterone NN cord-028721-x6f26ahr 3158 8 levels level NNS cord-028721-x6f26ahr 3158 9 low low JJ cord-028721-x6f26ahr 3158 10 or or CC cord-028721-x6f26ahr 3158 11 near near IN cord-028721-x6f26ahr 3158 12 normal normal JJ cord-028721-x6f26ahr 3158 13 . . . cord-028721-x6f26ahr 3159 1 The the DT cord-028721-x6f26ahr 3159 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 3159 3 tubules tubule NNS cord-028721-x6f26ahr 3159 4 have have VBP cord-028721-x6f26ahr 3159 5 reduced reduce VBN cord-028721-x6f26ahr 3159 6 diameters diameter NNS cord-028721-x6f26ahr 3159 7 , , , cord-028721-x6f26ahr 3159 8 thickening thickening NN cord-028721-x6f26ahr 3159 9 of of IN cord-028721-x6f26ahr 3159 10 the the DT cord-028721-x6f26ahr 3159 11 lamina lamina JJ cord-028721-x6f26ahr 3159 12 propria propria NN cord-028721-x6f26ahr 3159 13 , , , cord-028721-x6f26ahr 3159 14 and and CC cord-028721-x6f26ahr 3159 15 alterations alteration NNS cord-028721-x6f26ahr 3159 16 in in IN cord-028721-x6f26ahr 3159 17 the the DT cord-028721-x6f26ahr 3159 18 adluminal adluminal NNP cord-028721-x6f26ahr 3159 19 compartment compartment NNP cord-028721-x6f26ahr 3159 20 . . . cord-028721-x6f26ahr 3160 1 These these DT cord-028721-x6f26ahr 3160 2 consist consist VBP cord-028721-x6f26ahr 3160 3 of of IN cord-028721-x6f26ahr 3160 4 degenerative degenerative JJ cord-028721-x6f26ahr 3160 5 changes change NNS cord-028721-x6f26ahr 3160 6 in in IN cord-028721-x6f26ahr 3160 7 the the DT cord-028721-x6f26ahr 3160 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 3160 9 cell cell NN cord-028721-x6f26ahr 3160 10 apical apical JJ cord-028721-x6f26ahr 3160 11 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3160 12 and and CC cord-028721-x6f26ahr 3160 13 sloughing sloughing NN cord-028721-x6f26ahr 3160 14 of of IN cord-028721-x6f26ahr 3160 15 immature immature JJ cord-028721-x6f26ahr 3160 16 germ germ NN cord-028721-x6f26ahr 3160 17 cells cell NNS cord-028721-x6f26ahr 3160 18 . . . cord-028721-x6f26ahr 3161 1 The the DT cord-028721-x6f26ahr 3161 2 major major JJ cord-028721-x6f26ahr 3161 3 lesion lesion NN cord-028721-x6f26ahr 3161 4 is be VBZ cord-028721-x6f26ahr 3161 5 in in IN cord-028721-x6f26ahr 3161 6 the the DT cord-028721-x6f26ahr 3161 7 interstitial interstitial JJ cord-028721-x6f26ahr 3161 8 connective connective JJ cord-028721-x6f26ahr 3161 9 tissue tissue NN cord-028721-x6f26ahr 3161 10 and and CC cord-028721-x6f26ahr 3161 11 Leydig leydig NN cord-028721-x6f26ahr 3161 12 cells cell NNS cord-028721-x6f26ahr 3161 13 . . . cord-028721-x6f26ahr 3162 1 Small small JJ cord-028721-x6f26ahr 3162 2 interstitial interstitial JJ cord-028721-x6f26ahr 3162 3 blood blood NN cord-028721-x6f26ahr 3162 4 vessels vessel NNS cord-028721-x6f26ahr 3162 5 show show VBP cord-028721-x6f26ahr 3162 6 diabetic diabetic JJ cord-028721-x6f26ahr 3162 7 microangiopathy microangiopathy NNP cord-028721-x6f26ahr 3162 8 characterized characterize VBN cord-028721-x6f26ahr 3162 9 by by IN cord-028721-x6f26ahr 3162 10 enlargement enlargement NN cord-028721-x6f26ahr 3162 11 and and CC cord-028721-x6f26ahr 3162 12 duplication duplication NN cord-028721-x6f26ahr 3162 13 of of IN cord-028721-x6f26ahr 3162 14 the the DT cord-028721-x6f26ahr 3162 15 basal basal NN cord-028721-x6f26ahr 3162 16 lamina lamina NNP cord-028721-x6f26ahr 3162 17 , , , cord-028721-x6f26ahr 3162 18 pericyte pericyte NNP cord-028721-x6f26ahr 3162 19 degeneration degeneration NN cord-028721-x6f26ahr 3162 20 , , , cord-028721-x6f26ahr 3162 21 and and CC cord-028721-x6f26ahr 3162 22 endothelial endothelial JJ cord-028721-x6f26ahr 3162 23 cell cell NN cord-028721-x6f26ahr 3162 24 alterations alteration NNS cord-028721-x6f26ahr 3162 25 . . . cord-028721-x6f26ahr 3163 1 The the DT cord-028721-x6f26ahr 3163 2 number number NN cord-028721-x6f26ahr 3163 3 of of IN cord-028721-x6f26ahr 3163 4 fi fi NN cord-028721-x6f26ahr 3163 5 broblasts broblasts NNP cord-028721-x6f26ahr 3163 6 Infertility Infertility NNP cord-028721-x6f26ahr 3163 7 and and CC cord-028721-x6f26ahr 3163 8 the the DT cord-028721-x6f26ahr 3163 9 amount amount NN cord-028721-x6f26ahr 3163 10 of of IN cord-028721-x6f26ahr 3163 11 collagen collagen NN cord-028721-x6f26ahr 3163 12 and and CC cord-028721-x6f26ahr 3163 13 ground ground NN cord-028721-x6f26ahr 3163 14 substance substance NN cord-028721-x6f26ahr 3163 15 in in IN cord-028721-x6f26ahr 3163 16 the the DT cord-028721-x6f26ahr 3163 17 interstitial interstitial JJ cord-028721-x6f26ahr 3163 18 connective connective JJ cord-028721-x6f26ahr 3163 19 tissue tissue NN cord-028721-x6f26ahr 3163 20 are be VBP cord-028721-x6f26ahr 3163 21 increased increase VBN cord-028721-x6f26ahr 3163 22 . . . cord-028721-x6f26ahr 3164 1 1325 1325 CD cord-028721-x6f26ahr 3165 1 Leydig leydig NN cord-028721-x6f26ahr 3165 2 cells cell NNS cord-028721-x6f26ahr 3165 3 are be VBP cord-028721-x6f26ahr 3165 4 decreased decrease VBN cord-028721-x6f26ahr 3165 5 in in IN cord-028721-x6f26ahr 3165 6 number number NN cord-028721-x6f26ahr 3165 7 and and CC cord-028721-x6f26ahr 3165 8 show show NN cord-028721-x6f26ahr 3165 9 increased increase VBN cord-028721-x6f26ahr 3165 10 amounts amount NNS cord-028721-x6f26ahr 3165 11 of of IN cord-028721-x6f26ahr 3165 12 lipid lipid NN cord-028721-x6f26ahr 3165 13 droplets droplet NNS cord-028721-x6f26ahr 3165 14 and and CC cord-028721-x6f26ahr 3165 15 lysosomes lysosome NNS cord-028721-x6f26ahr 3165 16 , , , cord-028721-x6f26ahr 3165 17 accounting account VBG cord-028721-x6f26ahr 3165 18 for for IN cord-028721-x6f26ahr 3165 19 the the DT cord-028721-x6f26ahr 3165 20 reduced reduce VBN cord-028721-x6f26ahr 3165 21 function function NN cord-028721-x6f26ahr 3165 22 of of IN cord-028721-x6f26ahr 3165 23 these these DT cord-028721-x6f26ahr 3165 24 cells cell NNS cord-028721-x6f26ahr 3165 25 . . . cord-028721-x6f26ahr 3166 1 The the DT cord-028721-x6f26ahr 3166 2 tubular tubular JJ cord-028721-x6f26ahr 3166 3 lesions lesion NNS cord-028721-x6f26ahr 3166 4 are be VBP cord-028721-x6f26ahr 3166 5 attributed attribute VBN cord-028721-x6f26ahr 3166 6 to to IN cord-028721-x6f26ahr 3166 7 low low JJ cord-028721-x6f26ahr 3166 8 serum serum NN cord-028721-x6f26ahr 3166 9 testosterone testosterone NN cord-028721-x6f26ahr 3166 10 , , , cord-028721-x6f26ahr 3166 11 probably probably RB cord-028721-x6f26ahr 3166 12 owing owe VBG cord-028721-x6f26ahr 3166 13 to to IN cord-028721-x6f26ahr 3166 14 defi defi NNP cord-028721-x6f26ahr 3166 15 cient cient NNP cord-028721-x6f26ahr 3166 16 Leydig Leydig NNP cord-028721-x6f26ahr 3166 17 cell cell NN cord-028721-x6f26ahr 3166 18 stimulation stimulation NN cord-028721-x6f26ahr 3166 19 by by IN cord-028721-x6f26ahr 3166 20 insulin insulin NN cord-028721-x6f26ahr 3166 21 ( ( -LRB- cord-028721-x6f26ahr 3166 22 or or CC cord-028721-x6f26ahr 3166 23 a a DT cord-028721-x6f26ahr 3166 24 decrease decrease NN cord-028721-x6f26ahr 3166 25 in in IN cord-028721-x6f26ahr 3166 26 insulin insulin NN cord-028721-x6f26ahr 3166 27 - - HYPH cord-028721-x6f26ahr 3166 28 dependent dependent JJ cord-028721-x6f26ahr 3166 29 FSH fsh NN cord-028721-x6f26ahr 3166 30 ) ) -RRB- cord-028721-x6f26ahr 3166 31 and and CC cord-028721-x6f26ahr 3166 32 abnormal abnormal JJ cord-028721-x6f26ahr 3166 33 carbohydrate carbohydrate NN cord-028721-x6f26ahr 3166 34 metabolism metabolism NN cord-028721-x6f26ahr 3166 35 of of IN cord-028721-x6f26ahr 3166 36 Sertoli sertoli JJ cord-028721-x6f26ahr 3166 37 cells cell NNS cord-028721-x6f26ahr 3166 38 . . . cord-028721-x6f26ahr 3167 1 Sexual sexual JJ cord-028721-x6f26ahr 3167 2 dysfunction dysfunction NN cord-028721-x6f26ahr 3167 3 is be VBZ cord-028721-x6f26ahr 3167 4 present present JJ cord-028721-x6f26ahr 3167 5 in in IN cord-028721-x6f26ahr 3167 6 more more JJR cord-028721-x6f26ahr 3167 7 than than IN cord-028721-x6f26ahr 3167 8 half half NN cord-028721-x6f26ahr 3167 9 of of IN cord-028721-x6f26ahr 3167 10 patients patient NNS cord-028721-x6f26ahr 3167 11 and and CC cord-028721-x6f26ahr 3167 12 consists consist VBZ cord-028721-x6f26ahr 3167 13 of of IN cord-028721-x6f26ahr 3167 14 impotence impotence NN cord-028721-x6f26ahr 3167 15 , , , cord-028721-x6f26ahr 3167 16 decreased decrease VBD cord-028721-x6f26ahr 3167 17 libido libido NN cord-028721-x6f26ahr 3167 18 , , , cord-028721-x6f26ahr 3167 19 disorders disorder NNS cord-028721-x6f26ahr 3167 20 of of IN cord-028721-x6f26ahr 3167 21 intercourse intercourse NN cord-028721-x6f26ahr 3167 22 , , , cord-028721-x6f26ahr 3167 23 and and CC cord-028721-x6f26ahr 3167 24 retrograde retrograde JJ cord-028721-x6f26ahr 3167 25 ejaculation ejaculation NN cord-028721-x6f26ahr 3167 26 . . . cord-028721-x6f26ahr 3168 1 The the DT cord-028721-x6f26ahr 3168 2 causes cause NNS cord-028721-x6f26ahr 3168 3 of of IN cord-028721-x6f26ahr 3168 4 impotence impotence NN cord-028721-x6f26ahr 3168 5 are be VBP cord-028721-x6f26ahr 3168 6 multiple multiple JJ cord-028721-x6f26ahr 3168 7 , , , cord-028721-x6f26ahr 3168 8 including include VBG cord-028721-x6f26ahr 3168 9 microangiopathy microangiopathy NNP cord-028721-x6f26ahr 3168 10 and and CC cord-028721-x6f26ahr 3168 11 macroangiopathy macroangiopathy NNP cord-028721-x6f26ahr 3168 12 , , , cord-028721-x6f26ahr 3168 13 hormonal hormonal JJ cord-028721-x6f26ahr 3168 14 defi defi NNP cord-028721-x6f26ahr 3168 15 ciencies ciencie NNS cord-028721-x6f26ahr 3168 16 , , , cord-028721-x6f26ahr 3168 17 psychological psychological JJ cord-028721-x6f26ahr 3168 18 factors factor NNS cord-028721-x6f26ahr 3168 19 , , , cord-028721-x6f26ahr 3168 20 and and CC cord-028721-x6f26ahr 3168 21 autonomic autonomic JJ cord-028721-x6f26ahr 3168 22 neuropathy neuropathy NN cord-028721-x6f26ahr 3168 23 affecting affect VBG cord-028721-x6f26ahr 3168 24 the the DT cord-028721-x6f26ahr 3168 25 parasympathetic parasympathetic JJ cord-028721-x6f26ahr 3168 26 system system NN cord-028721-x6f26ahr 3168 27 . . . cord-028721-x6f26ahr 3169 1 Neuropathy neuropathy NN cord-028721-x6f26ahr 3169 2 is be VBZ cord-028721-x6f26ahr 3169 3 probably probably RB cord-028721-x6f26ahr 3169 4 chiefl chiefl NNP cord-028721-x6f26ahr 3169 5 y y NNP cord-028721-x6f26ahr 3169 6 responsible responsible JJ cord-028721-x6f26ahr 3169 7 for for IN cord-028721-x6f26ahr 3169 8 erectile erectile NN cord-028721-x6f26ahr 3169 9 failure failure NN cord-028721-x6f26ahr 3169 10 in in IN cord-028721-x6f26ahr 3169 11 diabetic diabetic JJ cord-028721-x6f26ahr 3169 12 men man NNS cord-028721-x6f26ahr 3169 13 . . . cord-028721-x6f26ahr 3170 1 1326 1326 CD cord-028721-x6f26ahr 3170 2 Alterations alteration NNS cord-028721-x6f26ahr 3170 3 in in IN cord-028721-x6f26ahr 3170 4 sperm sperm NN cord-028721-x6f26ahr 3170 5 excretory excretory JJ cord-028721-x6f26ahr 3170 6 ducts duct NNS cord-028721-x6f26ahr 3170 7 may may MD cord-028721-x6f26ahr 3170 8 be be VB cord-028721-x6f26ahr 3170 9 associated associate VBN cord-028721-x6f26ahr 3170 10 with with IN cord-028721-x6f26ahr 3170 11 diabetes diabete NNS cord-028721-x6f26ahr 3170 12 . . . cord-028721-x6f26ahr 3171 1 The the DT cord-028721-x6f26ahr 3171 2 most most RBS cord-028721-x6f26ahr 3171 3 frequent frequent JJ cord-028721-x6f26ahr 3171 4 are be VBP cord-028721-x6f26ahr 3171 5 enlarged enlarge VBN cord-028721-x6f26ahr 3171 6 seminal seminal JJ cord-028721-x6f26ahr 3171 7 vesicles vesicle NNS cord-028721-x6f26ahr 3171 8 and and CC cord-028721-x6f26ahr 3171 9 calcifi calcifi NN cord-028721-x6f26ahr 3171 10 cation cation NN cord-028721-x6f26ahr 3171 11 of of IN cord-028721-x6f26ahr 3171 12 both both CC cord-028721-x6f26ahr 3171 13 seminal seminal JJ cord-028721-x6f26ahr 3171 14 vesicles vesicle NNS cord-028721-x6f26ahr 3171 15 and and CC cord-028721-x6f26ahr 3171 16 vasa vasa NNP cord-028721-x6f26ahr 3171 17 deferentia deferentia NNP cord-028721-x6f26ahr 3171 18 . . . cord-028721-x6f26ahr 3172 1 Calcifi Calcifi NNP cord-028721-x6f26ahr 3172 2 cations cation NNS cord-028721-x6f26ahr 3172 3 are be VBP cord-028721-x6f26ahr 3172 4 found find VBN cord-028721-x6f26ahr 3172 5 in in IN cord-028721-x6f26ahr 3172 6 the the DT cord-028721-x6f26ahr 3172 7 muscular muscular JJ cord-028721-x6f26ahr 3172 8 layers layer NNS cord-028721-x6f26ahr 3172 9 and and CC cord-028721-x6f26ahr 3172 10 display display VB cord-028721-x6f26ahr 3172 11 a a DT cord-028721-x6f26ahr 3172 12 concentric concentric JJ cord-028721-x6f26ahr 3172 13 arrangement arrangement NN cord-028721-x6f26ahr 3172 14 ( ( -LRB- cord-028721-x6f26ahr 3172 15 Fig Fig NNP cord-028721-x6f26ahr 3172 16 . . . cord-028721-x6f26ahr 3172 17 12 12 CD cord-028721-x6f26ahr 3172 18 - - SYM cord-028721-x6f26ahr 3172 19 144 144 CD cord-028721-x6f26ahr 3172 20 ) ) -RRB- cord-028721-x6f26ahr 3172 21 . . . cord-028721-x6f26ahr 3173 1 1327 1327 CD cord-028721-x6f26ahr 3174 1 Although although IN cord-028721-x6f26ahr 3174 2 cystic cystic JJ cord-028721-x6f26ahr 3174 3 fi fi NN cord-028721-x6f26ahr 3174 4 brosis brosis NN cord-028721-x6f26ahr 3174 5 ( ( -LRB- cord-028721-x6f26ahr 3174 6 mucoviscidosis mucoviscidosis NNP cord-028721-x6f26ahr 3174 7 ) ) -RRB- cord-028721-x6f26ahr 3174 8 was be VBD cord-028721-x6f26ahr 3174 9 recognized recognize VBN cord-028721-x6f26ahr 3174 10 as as IN cord-028721-x6f26ahr 3174 11 a a DT cord-028721-x6f26ahr 3174 12 disease disease NN cord-028721-x6f26ahr 3174 13 prior prior RB cord-028721-x6f26ahr 3174 14 to to IN cord-028721-x6f26ahr 3174 15 1940 1940 CD cord-028721-x6f26ahr 3174 16 , , , cord-028721-x6f26ahr 3174 17 its -PRON- PRP$ cord-028721-x6f26ahr 3174 18 effects effect NNS cord-028721-x6f26ahr 3174 19 on on IN cord-028721-x6f26ahr 3174 20 the the DT cord-028721-x6f26ahr 3174 21 male male JJ cord-028721-x6f26ahr 3174 22 genital genital NN cord-028721-x6f26ahr 3174 23 system system NN cord-028721-x6f26ahr 3174 24 were be VBD cord-028721-x6f26ahr 3174 25 not not RB cord-028721-x6f26ahr 3174 26 recognized recognize VBN cord-028721-x6f26ahr 3174 27 until until IN cord-028721-x6f26ahr 3174 28 the the DT cord-028721-x6f26ahr 3174 29 1970s 1970s CD cord-028721-x6f26ahr 3174 30 . . . cord-028721-x6f26ahr 3175 1 This this DT cord-028721-x6f26ahr 3175 2 may may MD cord-028721-x6f26ahr 3175 3 be be VB cord-028721-x6f26ahr 3175 4 explained explain VBN cord-028721-x6f26ahr 3175 5 by by IN cord-028721-x6f26ahr 3175 6 improvements improvement NNS cord-028721-x6f26ahr 3175 7 in in IN cord-028721-x6f26ahr 3175 8 medical medical JJ cord-028721-x6f26ahr 3175 9 care care NN cord-028721-x6f26ahr 3175 10 during during IN cord-028721-x6f26ahr 3175 11 childhood childhood NN cord-028721-x6f26ahr 3175 12 , , , cord-028721-x6f26ahr 3175 13 allowing allow VBG cord-028721-x6f26ahr 3175 14 the the DT cord-028721-x6f26ahr 3175 15 survival survival NN cord-028721-x6f26ahr 3175 16 of of IN cord-028721-x6f26ahr 3175 17 many many JJ cord-028721-x6f26ahr 3175 18 patients patient NNS cord-028721-x6f26ahr 3175 19 to to IN cord-028721-x6f26ahr 3175 20 adulthood adulthood NN cord-028721-x6f26ahr 3175 21 , , , cord-028721-x6f26ahr 3175 22 and and CC cord-028721-x6f26ahr 3175 23 the the DT cord-028721-x6f26ahr 3175 24 recognition recognition NN cord-028721-x6f26ahr 3175 25 of of IN cord-028721-x6f26ahr 3175 26 cystic cystic NN cord-028721-x6f26ahr 3175 27 fi fi NN cord-028721-x6f26ahr 3175 28 brosis brosis NN cord-028721-x6f26ahr 3175 29 in in IN cord-028721-x6f26ahr 3175 30 patients patient NNS cord-028721-x6f26ahr 3175 31 who who WP cord-028721-x6f26ahr 3175 32 had have VBD cord-028721-x6f26ahr 3175 33 been be VBN cord-028721-x6f26ahr 3175 34 diagnosed diagnose VBN cord-028721-x6f26ahr 3175 35 with with IN cord-028721-x6f26ahr 3175 36 chronic chronic JJ cord-028721-x6f26ahr 3175 37 bronchitis bronchitis NN cord-028721-x6f26ahr 3175 38 and and CC cord-028721-x6f26ahr 3175 39 hepatic hepatic JJ cord-028721-x6f26ahr 3175 40 or or CC cord-028721-x6f26ahr 3175 41 digestive digestive JJ cord-028721-x6f26ahr 3175 42 dysfunction dysfunction NN cord-028721-x6f26ahr 3175 43 . . . cord-028721-x6f26ahr 3176 1 In in IN cord-028721-x6f26ahr 3176 2 the the DT cord-028721-x6f26ahr 3176 3 US US NNP cord-028721-x6f26ahr 3176 4 , , , cord-028721-x6f26ahr 3176 5 cystic cystic JJ cord-028721-x6f26ahr 3176 6 fi fi NN cord-028721-x6f26ahr 3176 7 brosis brosis NN cord-028721-x6f26ahr 3176 8 is be VBZ cord-028721-x6f26ahr 3176 9 the the DT cord-028721-x6f26ahr 3176 10 most most RBS cord-028721-x6f26ahr 3176 11 lethal lethal JJ cord-028721-x6f26ahr 3176 12 congenital congenital JJ cord-028721-x6f26ahr 3176 13 disease disease NN cord-028721-x6f26ahr 3176 14 , , , cord-028721-x6f26ahr 3176 15 with with IN cord-028721-x6f26ahr 3176 16 a a DT cord-028721-x6f26ahr 3176 17 prevalence prevalence NN cord-028721-x6f26ahr 3176 18 of of IN cord-028721-x6f26ahr 3176 19 1 1 CD cord-028721-x6f26ahr 3176 20 in in IN cord-028721-x6f26ahr 3176 21 2500 2500 CD cord-028721-x6f26ahr 3176 22 children child NNS cord-028721-x6f26ahr 3176 23 , , , cord-028721-x6f26ahr 3176 24 and and CC cord-028721-x6f26ahr 3176 25 a a DT cord-028721-x6f26ahr 3176 26 carrier carrier NN cord-028721-x6f26ahr 3176 27 status status NN cord-028721-x6f26ahr 3176 28 of of IN cord-028721-x6f26ahr 3176 29 1 1 CD cord-028721-x6f26ahr 3176 30 in in IN cord-028721-x6f26ahr 3176 31 25 25 CD cord-028721-x6f26ahr 3176 32 white white JJ cord-028721-x6f26ahr 3176 33 men man NNS cord-028721-x6f26ahr 3176 34 . . . cord-028721-x6f26ahr 3177 1 1328 1328 CD cord-028721-x6f26ahr 3177 2 Lesions lesion NNS cord-028721-x6f26ahr 3177 3 in in IN cord-028721-x6f26ahr 3177 4 sperm sperm NN cord-028721-x6f26ahr 3177 5 excretory excretory JJ cord-028721-x6f26ahr 3177 6 ducts duct NNS cord-028721-x6f26ahr 3177 7 involve involve VBP cord-028721-x6f26ahr 3177 8 ( ( -LRB- cord-028721-x6f26ahr 3177 9 in in IN cord-028721-x6f26ahr 3177 10 decreasing decrease VBG cord-028721-x6f26ahr 3177 11 order order NN cord-028721-x6f26ahr 3177 12 of of IN cord-028721-x6f26ahr 3177 13 frequency frequency NN cord-028721-x6f26ahr 3177 14 ) ) -RRB- cord-028721-x6f26ahr 3178 1 the the DT cord-028721-x6f26ahr 3178 2 vas vas NNP cord-028721-x6f26ahr 3178 3 deferens deferen NNS cord-028721-x6f26ahr 3178 4 ( ( -LRB- cord-028721-x6f26ahr 3178 5 congenital congenital JJ cord-028721-x6f26ahr 3178 6 bilateral bilateral JJ cord-028721-x6f26ahr 3178 7 absence absence NN cord-028721-x6f26ahr 3178 8 , , , cord-028721-x6f26ahr 3178 9 unilateral unilateral JJ cord-028721-x6f26ahr 3178 10 absence absence NN cord-028721-x6f26ahr 3178 11 ) ) -RRB- cord-028721-x6f26ahr 3178 12 , , , cord-028721-x6f26ahr 3178 13 ejaculatory ejaculatory NN cord-028721-x6f26ahr 3178 14 ducts duct NNS cord-028721-x6f26ahr 3178 15 ( ( -LRB- cord-028721-x6f26ahr 3178 16 bilateral bilateral JJ cord-028721-x6f26ahr 3178 17 obstruction obstruction NN cord-028721-x6f26ahr 3178 18 ) ) -RRB- cord-028721-x6f26ahr 3178 19 , , , cord-028721-x6f26ahr 3178 20 epididymis epididymis FW cord-028721-x6f26ahr 3178 21 ( ( -LRB- cord-028721-x6f26ahr 3178 22 diffuse diffuse JJ cord-028721-x6f26ahr 3178 23 or or CC cord-028721-x6f26ahr 3178 24 segmental segmental JJ cord-028721-x6f26ahr 3178 25 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3178 26 ) ) -RRB- cord-028721-x6f26ahr 3178 27 , , , cord-028721-x6f26ahr 3178 28 and and CC cord-028721-x6f26ahr 3178 29 seminal seminal JJ cord-028721-x6f26ahr 3178 30 vesicles vesicle NNS cord-028721-x6f26ahr 3178 31 ( ( -LRB- cord-028721-x6f26ahr 3178 32 incomplete incomplete JJ cord-028721-x6f26ahr 3178 33 development development NN cord-028721-x6f26ahr 3178 34 ) ) -RRB- cord-028721-x6f26ahr 3178 35 . . . cord-028721-x6f26ahr 3179 1 Thus thus RB cord-028721-x6f26ahr 3179 2 , , , cord-028721-x6f26ahr 3179 3 it -PRON- PRP cord-028721-x6f26ahr 3179 4 appears appear VBZ cord-028721-x6f26ahr 3179 5 that that IN cord-028721-x6f26ahr 3179 6 most most JJS cord-028721-x6f26ahr 3179 7 patients patient NNS cord-028721-x6f26ahr 3179 8 with with IN cord-028721-x6f26ahr 3179 9 cystic cystic NN cord-028721-x6f26ahr 3179 10 fi fi NN cord-028721-x6f26ahr 3179 11 brosis brosis NN cord-028721-x6f26ahr 3179 12 have have VBP cord-028721-x6f26ahr 3179 13 infertility infertility NN cord-028721-x6f26ahr 3179 14 due due IN cord-028721-x6f26ahr 3179 15 to to IN cord-028721-x6f26ahr 3179 16 obstruction obstruction NN cord-028721-x6f26ahr 3179 17 . . . cord-028721-x6f26ahr 3180 1 1329 1329 CD cord-028721-x6f26ahr 3180 2 , , , cord-028721-x6f26ahr 3180 3 1330 1330 CD cord-028721-x6f26ahr 3180 4 Histologic Histologic NNP cord-028721-x6f26ahr 3180 5 studies study NNS cord-028721-x6f26ahr 3180 6 in in IN cord-028721-x6f26ahr 3180 7 children child NNS cord-028721-x6f26ahr 3180 8 , , , cord-028721-x6f26ahr 3180 9 even even RB cord-028721-x6f26ahr 3180 10 at at IN cord-028721-x6f26ahr 3180 11 an an DT cord-028721-x6f26ahr 3180 12 early early JJ cord-028721-x6f26ahr 3180 13 age age NN cord-028721-x6f26ahr 3180 14 , , , cord-028721-x6f26ahr 3180 15 reveal reveal VBP cord-028721-x6f26ahr 3180 16 that that IN cord-028721-x6f26ahr 3180 17 the the DT cord-028721-x6f26ahr 3180 18 vas vas NNP cord-028721-x6f26ahr 3180 19 deferens deferen NNS cord-028721-x6f26ahr 3180 20 and and CC cord-028721-x6f26ahr 3180 21 ductus ductus NN cord-028721-x6f26ahr 3180 22 epididymis epididymis NN cord-028721-x6f26ahr 3180 23 are be VBP cord-028721-x6f26ahr 3180 24 absent absent JJ cord-028721-x6f26ahr 3180 25 or or CC cord-028721-x6f26ahr 3180 26 reduced reduce VBN cord-028721-x6f26ahr 3180 27 to to IN cord-028721-x6f26ahr 3180 28 small small JJ cord-028721-x6f26ahr 3180 29 ductuli ductuli NN cord-028721-x6f26ahr 3180 30 with with IN cord-028721-x6f26ahr 3180 31 reduced reduced JJ cord-028721-x6f26ahr 3180 32 or or CC cord-028721-x6f26ahr 3180 33 absent absent JJ cord-028721-x6f26ahr 3180 34 lumina lumina NNP cord-028721-x6f26ahr 3180 35 and and CC cord-028721-x6f26ahr 3180 36 thin thin JJ cord-028721-x6f26ahr 3180 37 , , , cord-028721-x6f26ahr 3180 38 poorly poorly RB cord-028721-x6f26ahr 3180 39 muscular muscular JJ cord-028721-x6f26ahr 3180 40 walls wall NNS cord-028721-x6f26ahr 3180 41 ( ( -LRB- cord-028721-x6f26ahr 3180 42 Fig Fig NNP cord-028721-x6f26ahr 3180 43 . . . cord-028721-x6f26ahr 3180 44 12 12 CD cord-028721-x6f26ahr 3180 45 - - SYM cord-028721-x6f26ahr 3180 46 145 145 CD cord-028721-x6f26ahr 3180 47 ) ) -RRB- cord-028721-x6f26ahr 3180 48 . . . cord-028721-x6f26ahr 3181 1 The the DT cord-028721-x6f26ahr 3181 2 testes testis NNS cord-028721-x6f26ahr 3181 3 are be VBP cord-028721-x6f26ahr 3181 4 normal normal JJ cord-028721-x6f26ahr 3181 5 during during IN cord-028721-x6f26ahr 3181 6 childhood childhood NN cord-028721-x6f26ahr 3181 7 , , , cord-028721-x6f26ahr 3181 8 but but CC cord-028721-x6f26ahr 3181 9 show show VB cord-028721-x6f26ahr 3181 10 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 3181 11 and and CC cord-028721-x6f26ahr 3181 12 spermatid spermatid JJ cord-028721-x6f26ahr 3181 13 malformations malformation NNS cord-028721-x6f26ahr 3181 14 by by IN cord-028721-x6f26ahr 3181 15 adulthood adulthood NN cord-028721-x6f26ahr 3181 16 . . . cord-028721-x6f26ahr 3182 1 The the DT cord-028721-x6f26ahr 3182 2 spermiogram spermiogram NNP cord-028721-x6f26ahr 3182 3 is be VBZ cord-028721-x6f26ahr 3182 4 characteristic characteristic JJ cord-028721-x6f26ahr 3182 5 of of IN cord-028721-x6f26ahr 3182 6 obstructive obstructive JJ cord-028721-x6f26ahr 3182 7 azoospermia azoospermia NN cord-028721-x6f26ahr 3182 8 , , , cord-028721-x6f26ahr 3182 9 with with IN cord-028721-x6f26ahr 3182 10 acid acid NN cord-028721-x6f26ahr 3182 11 pH ph NN cord-028721-x6f26ahr 3182 12 , , , cord-028721-x6f26ahr 3182 13 decreased decrease VBD cord-028721-x6f26ahr 3182 14 semen semen NN cord-028721-x6f26ahr 3182 15 volume volume NN cord-028721-x6f26ahr 3182 16 and and CC cord-028721-x6f26ahr 3182 17 fructose fructose NN cord-028721-x6f26ahr 3182 18 concentration concentration NN cord-028721-x6f26ahr 3182 19 , , , cord-028721-x6f26ahr 3182 20 and and CC cord-028721-x6f26ahr 3182 21 increased increase VBN cord-028721-x6f26ahr 3182 22 citric citric JJ cord-028721-x6f26ahr 3182 23 acid acid NN cord-028721-x6f26ahr 3182 24 and and CC cord-028721-x6f26ahr 3182 25 acid acid NN cord-028721-x6f26ahr 3182 26 phosphatase phosphatase NN cord-028721-x6f26ahr 3182 27 . . . cord-028721-x6f26ahr 3183 1 1331 1331 CD cord-028721-x6f26ahr 3184 1 The the DT cord-028721-x6f26ahr 3184 2 disease disease NN cord-028721-x6f26ahr 3184 3 is be VBZ cord-028721-x6f26ahr 3184 4 a a DT cord-028721-x6f26ahr 3184 5 genetic genetic JJ cord-028721-x6f26ahr 3184 6 disorder disorder NN cord-028721-x6f26ahr 3184 7 with with IN cord-028721-x6f26ahr 3184 8 autosomal autosomal JJ cord-028721-x6f26ahr 3184 9 recessive recessive JJ cord-028721-x6f26ahr 3184 10 inheritance inheritance NN cord-028721-x6f26ahr 3184 11 . . . cord-028721-x6f26ahr 3185 1 The the DT cord-028721-x6f26ahr 3185 2 impaired impaired JJ cord-028721-x6f26ahr 3185 3 gene gene NN cord-028721-x6f26ahr 3185 4 ( ( -LRB- cord-028721-x6f26ahr 3185 5 cystic cystic NNP cord-028721-x6f26ahr 3185 6 fi fi NN cord-028721-x6f26ahr 3185 7 brosis brosis NNP cord-028721-x6f26ahr 3185 8 gene gene NN cord-028721-x6f26ahr 3185 9 ) ) -RRB- cord-028721-x6f26ahr 3185 10 is be VBZ cord-028721-x6f26ahr 3185 11 on on IN cord-028721-x6f26ahr 3185 12 chromosome chromosome NN cord-028721-x6f26ahr 3185 13 7 7 CD cord-028721-x6f26ahr 3185 14 ( ( -LRB- cord-028721-x6f26ahr 3185 15 7q31 7q31 CD cord-028721-x6f26ahr 3185 16 ) ) -RRB- cord-028721-x6f26ahr 3185 17 , , , cord-028721-x6f26ahr 3185 18 1332 1332 CD cord-028721-x6f26ahr 3185 19 and and CC cord-028721-x6f26ahr 3185 20 encodes encode VBZ cord-028721-x6f26ahr 3185 21 a a DT cord-028721-x6f26ahr 3185 22 protein protein NN cord-028721-x6f26ahr 3185 23 termed term VBN cord-028721-x6f26ahr 3185 24 cystic cystic JJ cord-028721-x6f26ahr 3185 25 fi fi NN cord-028721-x6f26ahr 3185 26 brosis brosis NN cord-028721-x6f26ahr 3185 27 transmembrane transmembrane NNP cord-028721-x6f26ahr 3185 28 regulator regulator NN cord-028721-x6f26ahr 3185 29 ( ( -LRB- cord-028721-x6f26ahr 3185 30 CFTR CFTR NNP cord-028721-x6f26ahr 3185 31 ) ) -RRB- cord-028721-x6f26ahr 3185 32 . . . cord-028721-x6f26ahr 3186 1 Alterations alteration NNS cord-028721-x6f26ahr 3186 2 in in IN cord-028721-x6f26ahr 3186 3 this this DT cord-028721-x6f26ahr 3186 4 protein protein NN cord-028721-x6f26ahr 3186 5 cause cause VB cord-028721-x6f26ahr 3186 6 cystic cystic NN cord-028721-x6f26ahr 3186 7 fi fi NN cord-028721-x6f26ahr 3186 8 brosis brosis NN cord-028721-x6f26ahr 3186 9 . . . cord-028721-x6f26ahr 3187 1 Although although IN cord-028721-x6f26ahr 3187 2 more more JJR cord-028721-x6f26ahr 3187 3 than than IN cord-028721-x6f26ahr 3187 4 800 800 CD cord-028721-x6f26ahr 3187 5 mutations mutation NNS cord-028721-x6f26ahr 3187 6 of of IN cord-028721-x6f26ahr 3187 7 this this DT cord-028721-x6f26ahr 3187 8 gene gene NN cord-028721-x6f26ahr 3187 9 have have VBP cord-028721-x6f26ahr 3187 10 been be VBN cord-028721-x6f26ahr 3187 11 identifi identifi VBN cord-028721-x6f26ahr 3187 12 ed ed NNP cord-028721-x6f26ahr 3187 13 , , , cord-028721-x6f26ahr 3187 14 1333 1333 CD cord-028721-x6f26ahr 3187 15 the the DT cord-028721-x6f26ahr 3187 16 most most RBS cord-028721-x6f26ahr 3187 17 frequent frequent JJ cord-028721-x6f26ahr 3187 18 mutation mutation NN cord-028721-x6f26ahr 3187 19 in in IN cord-028721-x6f26ahr 3187 20 Caucasians Caucasians NNPS cord-028721-x6f26ahr 3187 21 is be VBZ cord-028721-x6f26ahr 3187 22 D D NNP cord-028721-x6f26ahr 3187 23 - - HYPH cord-028721-x6f26ahr 3187 24 F508 f508 JJ cord-028721-x6f26ahr 3187 25 , , , cord-028721-x6f26ahr 3187 26 responsible responsible JJ cord-028721-x6f26ahr 3187 27 for for IN cord-028721-x6f26ahr 3187 28 70 70 CD cord-028721-x6f26ahr 3187 29 % % NN cord-028721-x6f26ahr 3187 30 of of IN cord-028721-x6f26ahr 3187 31 cases case NNS cord-028721-x6f26ahr 3187 32 . . . cord-028721-x6f26ahr 3188 1 Congenital congenital JJ cord-028721-x6f26ahr 3188 2 bilateral bilateral JJ cord-028721-x6f26ahr 3188 3 obstructive obstructive JJ cord-028721-x6f26ahr 3188 4 azoospermia azoospermia NN cord-028721-x6f26ahr 3188 5 secondary secondary JJ cord-028721-x6f26ahr 3188 6 to to IN cord-028721-x6f26ahr 3188 7 bilateral bilateral JJ cord-028721-x6f26ahr 3188 8 absence absence NN cord-028721-x6f26ahr 3188 9 of of IN cord-028721-x6f26ahr 3188 10 the the DT cord-028721-x6f26ahr 3188 11 vas vas NNP cord-028721-x6f26ahr 3188 12 deferens deferen NNS cord-028721-x6f26ahr 3188 13 , , , cord-028721-x6f26ahr 3188 14 even even RB cord-028721-x6f26ahr 3188 15 in in IN cord-028721-x6f26ahr 3188 16 the the DT cord-028721-x6f26ahr 3188 17 absence absence NN cord-028721-x6f26ahr 3188 18 of of IN cord-028721-x6f26ahr 3188 19 other other JJ cord-028721-x6f26ahr 3188 20 symptoms symptom NNS cord-028721-x6f26ahr 3188 21 , , , cord-028721-x6f26ahr 3188 22 is be VBZ cord-028721-x6f26ahr 3188 23 often often RB cord-028721-x6f26ahr 3188 24 a a DT cord-028721-x6f26ahr 3188 25 forme forme FW cord-028721-x6f26ahr 3188 26 fruste fruste NN cord-028721-x6f26ahr 3188 27 of of IN cord-028721-x6f26ahr 3188 28 cystic cystic NNP cord-028721-x6f26ahr 3188 29 fi fi NNP cord-028721-x6f26ahr 3188 30 brosis brosis NN cord-028721-x6f26ahr 3188 31 . . . cord-028721-x6f26ahr 3189 1 1334 1334 CD cord-028721-x6f26ahr 3190 1 Before before IN cord-028721-x6f26ahr 3190 2 initiating initiate VBG cord-028721-x6f26ahr 3190 3 treatment treatment NN cord-028721-x6f26ahr 3190 4 for for IN cord-028721-x6f26ahr 3190 5 infertility infertility NN cord-028721-x6f26ahr 3190 6 , , , cord-028721-x6f26ahr 3190 7 the the DT cord-028721-x6f26ahr 3190 8 possibility possibility NN cord-028721-x6f26ahr 3190 9 that that IN cord-028721-x6f26ahr 3190 10 the the DT cord-028721-x6f26ahr 3190 11 patient patient NN cord-028721-x6f26ahr 3190 12 is be VBZ cord-028721-x6f26ahr 3190 13 a a DT cord-028721-x6f26ahr 3190 14 carrier carrier NN cord-028721-x6f26ahr 3190 15 of of IN cord-028721-x6f26ahr 3190 16 the the DT cord-028721-x6f26ahr 3190 17 cystic cystic NN cord-028721-x6f26ahr 3190 18 fi fi NNP cord-028721-x6f26ahr 3190 19 brosis brosis NN cord-028721-x6f26ahr 3190 20 gene gene NN cord-028721-x6f26ahr 3190 21 should should MD cord-028721-x6f26ahr 3190 22 be be VB cord-028721-x6f26ahr 3190 23 evaluated evaluate VBN cord-028721-x6f26ahr 3190 24 . . . cord-028721-x6f26ahr 3191 1 1335 1335 CD cord-028721-x6f26ahr 3191 2 Malformation Malformation NNP cord-028721-x6f26ahr 3191 3 of of IN cord-028721-x6f26ahr 3191 4 the the DT cord-028721-x6f26ahr 3191 5 genital genital JJ cord-028721-x6f26ahr 3191 6 system system NN cord-028721-x6f26ahr 3191 7 plays play VBZ cord-028721-x6f26ahr 3191 8 the the DT cord-028721-x6f26ahr 3191 9 most most RBS cord-028721-x6f26ahr 3191 10 important important JJ cord-028721-x6f26ahr 3191 11 role role NN cord-028721-x6f26ahr 3191 12 in in IN cord-028721-x6f26ahr 3191 13 infertility infertility NN cord-028721-x6f26ahr 3191 14 in in IN cord-028721-x6f26ahr 3191 15 cystic cystic NN cord-028721-x6f26ahr 3191 16 fi fi NN cord-028721-x6f26ahr 3191 17 brosis brosis NN cord-028721-x6f26ahr 3191 18 . . . cord-028721-x6f26ahr 3192 1 1336 1336 CD cord-028721-x6f26ahr 3193 1 The the DT cord-028721-x6f26ahr 3193 2 lesions lesion NNS cord-028721-x6f26ahr 3193 3 begin begin VBP cord-028721-x6f26ahr 3193 4 in in IN cord-028721-x6f26ahr 3193 5 the the DT cord-028721-x6f26ahr 3193 6 10th 10th JJ cord-028721-x6f26ahr 3193 7 week week NN cord-028721-x6f26ahr 3193 8 of of IN cord-028721-x6f26ahr 3193 9 gestation gestation NN cord-028721-x6f26ahr 3193 10 , , , cord-028721-x6f26ahr 3193 11 when when WRB cord-028721-x6f26ahr 3193 12 the the DT cord-028721-x6f26ahr 3193 13 wolffi wolffi NN cord-028721-x6f26ahr 3193 14 an an DT cord-028721-x6f26ahr 3193 15 duct duct NN cord-028721-x6f26ahr 3193 16 forms form VBZ cord-028721-x6f26ahr 3193 17 the the DT cord-028721-x6f26ahr 3193 18 sperm sperm NN cord-028721-x6f26ahr 3193 19 excretory excretory JJ cord-028721-x6f26ahr 3193 20 ducts duct NNS cord-028721-x6f26ahr 3193 21 . . . cord-028721-x6f26ahr 3194 1 1337 1337 CD cord-028721-x6f26ahr 3194 2 Variable variable JJ cord-028721-x6f26ahr 3194 3 penetrance penetrance NN cord-028721-x6f26ahr 3194 4 of of IN cord-028721-x6f26ahr 3194 5 the the DT cord-028721-x6f26ahr 3194 6 cystic cystic NN cord-028721-x6f26ahr 3194 7 fi fi NNP cord-028721-x6f26ahr 3194 8 brosis brosis NNP cord-028721-x6f26ahr 3194 9 gene gene NN cord-028721-x6f26ahr 3194 10 accounts account VBZ cord-028721-x6f26ahr 3194 11 for for IN cord-028721-x6f26ahr 3194 12 the the DT cord-028721-x6f26ahr 3194 13 diversity diversity NN cord-028721-x6f26ahr 3194 14 of of IN cord-028721-x6f26ahr 3194 15 malformations malformation NNS cord-028721-x6f26ahr 3194 16 affecting affect VBG cord-028721-x6f26ahr 3194 17 different different JJ cord-028721-x6f26ahr 3194 18 regions region NNS cord-028721-x6f26ahr 3194 19 of of IN cord-028721-x6f26ahr 3194 20 the the DT cord-028721-x6f26ahr 3194 21 male male JJ cord-028721-x6f26ahr 3194 22 genital genital NN cord-028721-x6f26ahr 3194 23 system system NN cord-028721-x6f26ahr 3194 24 . . . cord-028721-x6f26ahr 3195 1 The the DT cord-028721-x6f26ahr 3195 2 liver liver NN cord-028721-x6f26ahr 3195 3 has have VBZ cord-028721-x6f26ahr 3195 4 a a DT cord-028721-x6f26ahr 3195 5 primary primary JJ cord-028721-x6f26ahr 3195 6 role role NN cord-028721-x6f26ahr 3195 7 in in IN cord-028721-x6f26ahr 3195 8 metabolism metabolism NN cord-028721-x6f26ahr 3195 9 , , , cord-028721-x6f26ahr 3195 10 detoxifi detoxifi NNP cord-028721-x6f26ahr 3195 11 cation cation NNP cord-028721-x6f26ahr 3195 12 , , , cord-028721-x6f26ahr 3195 13 and and CC cord-028721-x6f26ahr 3195 14 excretion excretion NN cord-028721-x6f26ahr 3195 15 of of IN cord-028721-x6f26ahr 3195 16 sex sex NN cord-028721-x6f26ahr 3195 17 steroid steroid NN cord-028721-x6f26ahr 3195 18 hormones hormone NNS cord-028721-x6f26ahr 3195 19 . . . cord-028721-x6f26ahr 3196 1 Chronic chronic JJ cord-028721-x6f26ahr 3196 2 hepatic hepatic JJ cord-028721-x6f26ahr 3196 3 failure failure NN cord-028721-x6f26ahr 3196 4 damages damage VBZ cord-028721-x6f26ahr 3196 5 the the DT cord-028721-x6f26ahr 3196 6 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 3196 7 - - HYPH cord-028721-x6f26ahr 3196 8 hypophyseal hypophyseal JJ cord-028721-x6f26ahr 3196 9 - - HYPH cord-028721-x6f26ahr 3196 10 testicular testicular JJ cord-028721-x6f26ahr 3196 11 axis axis NN cord-028721-x6f26ahr 3196 12 , , , cord-028721-x6f26ahr 3196 13 and and CC cord-028721-x6f26ahr 3196 14 subsequently subsequently RB cord-028721-x6f26ahr 3196 15 all all DT cord-028721-x6f26ahr 3196 16 related relate VBN cord-028721-x6f26ahr 3196 17 endocrine endocrine JJ cord-028721-x6f26ahr 3196 18 glands gland NNS cord-028721-x6f26ahr 3196 19 . . . cord-028721-x6f26ahr 3197 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3197 2 is be VBZ cord-028721-x6f26ahr 3197 3 frequent frequent JJ cord-028721-x6f26ahr 3197 4 in in IN cord-028721-x6f26ahr 3197 5 the the DT cord-028721-x6f26ahr 3197 6 fi fi NN cord-028721-x6f26ahr 3197 7 nal nal FW cord-028721-x6f26ahr 3197 8 stages stage NNS cord-028721-x6f26ahr 3197 9 of of IN cord-028721-x6f26ahr 3197 10 severe severe JJ cord-028721-x6f26ahr 3197 11 chronic chronic JJ cord-028721-x6f26ahr 3197 12 liver liver NN cord-028721-x6f26ahr 3197 13 diseases disease NNS cord-028721-x6f26ahr 3197 14 , , , cord-028721-x6f26ahr 3197 15 including include VBG cord-028721-x6f26ahr 3197 16 alcoholism alcoholism NN cord-028721-x6f26ahr 3197 17 , , , cord-028721-x6f26ahr 3197 18 non non JJ cord-028721-x6f26ahr 3197 19 - - JJ cord-028721-x6f26ahr 3197 20 alcoholic alcoholic JJ cord-028721-x6f26ahr 3197 21 liver liver NN cord-028721-x6f26ahr 3197 22 disease disease NN cord-028721-x6f26ahr 3197 23 , , , cord-028721-x6f26ahr 3197 24 and and CC cord-028721-x6f26ahr 3197 25 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3197 26 . . . cord-028721-x6f26ahr 3198 1 The the DT cord-028721-x6f26ahr 3198 2 association association NN cord-028721-x6f26ahr 3198 3 of of IN cord-028721-x6f26ahr 3198 4 testicular testicular JJ cord-028721-x6f26ahr 3198 5 atrophy atrophy NN cord-028721-x6f26ahr 3198 6 with with IN cord-028721-x6f26ahr 3198 7 gynecomastia gynecomastia NN cord-028721-x6f26ahr 3198 8 and and CC cord-028721-x6f26ahr 3198 9 hepatic hepatic JJ cord-028721-x6f26ahr 3198 10 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3198 11 is be VBZ cord-028721-x6f26ahr 3198 12 well well RB cord-028721-x6f26ahr 3198 13 known know VBN cord-028721-x6f26ahr 3198 14 and and CC cord-028721-x6f26ahr 3198 15 is be VBZ cord-028721-x6f26ahr 3198 16 referred refer VBN cord-028721-x6f26ahr 3198 17 to to IN cord-028721-x6f26ahr 3198 18 as as IN cord-028721-x6f26ahr 3198 19 Silvestrini Silvestrini NNP cord-028721-x6f26ahr 3198 20 - - HYPH cord-028721-x6f26ahr 3198 21 Corda Corda NNP cord-028721-x6f26ahr 3198 22 syndrome syndrome NN cord-028721-x6f26ahr 3198 23 . . . cord-028721-x6f26ahr 3199 1 1338 1338 CD cord-028721-x6f26ahr 3199 2 , , , cord-028721-x6f26ahr 3199 3 1339 1339 CD cord-028721-x6f26ahr 3199 4 Alcohol Alcohol NNP cord-028721-x6f26ahr 3199 5 has have VBZ cord-028721-x6f26ahr 3199 6 a a DT cord-028721-x6f26ahr 3199 7 direct direct JJ cord-028721-x6f26ahr 3199 8 toxic toxic JJ cord-028721-x6f26ahr 3199 9 effect effect NN cord-028721-x6f26ahr 3199 10 on on IN cord-028721-x6f26ahr 3199 11 Leydig Leydig NNP cord-028721-x6f26ahr 3199 12 cells cell NNS cord-028721-x6f26ahr 3199 13 . . . cord-028721-x6f26ahr 3200 1 Acute acute JJ cord-028721-x6f26ahr 3200 2 alcoholic alcoholic JJ cord-028721-x6f26ahr 3200 3 intoxication intoxication NN cord-028721-x6f26ahr 3200 4 suppresses suppress VBZ cord-028721-x6f26ahr 3200 5 serum serum NN cord-028721-x6f26ahr 3200 6 testosterone testosterone NN cord-028721-x6f26ahr 3200 7 in in IN cord-028721-x6f26ahr 3200 8 voluntary voluntary JJ cord-028721-x6f26ahr 3200 9 non non JJ cord-028721-x6f26ahr 3200 10 - - JJ cord-028721-x6f26ahr 3200 11 alcoholic alcoholic JJ cord-028721-x6f26ahr 3200 12 men man NNS cord-028721-x6f26ahr 3200 13 and and CC cord-028721-x6f26ahr 3200 14 laboratory laboratory NN cord-028721-x6f26ahr 3200 15 animals animal NNS cord-028721-x6f26ahr 3200 16 . . . cord-028721-x6f26ahr 3201 1 Chronic chronic JJ cord-028721-x6f26ahr 3201 2 alcohol alcohol NN cord-028721-x6f26ahr 3201 3 ingestion ingestion NN cord-028721-x6f26ahr 3201 4 , , , cord-028721-x6f26ahr 3201 5 even even RB cord-028721-x6f26ahr 3201 6 in in IN cord-028721-x6f26ahr 3201 7 the the DT cord-028721-x6f26ahr 3201 8 absence absence NN cord-028721-x6f26ahr 3201 9 of of IN cord-028721-x6f26ahr 3201 10 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3201 11 , , , cord-028721-x6f26ahr 3201 12 causes cause VBZ cord-028721-x6f26ahr 3201 13 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3201 14 , , , cord-028721-x6f26ahr 3201 15 with with IN cord-028721-x6f26ahr 3201 16 symptoms symptom NNS cord-028721-x6f26ahr 3201 17 of of IN cord-028721-x6f26ahr 3201 18 Leydig Leydig NNP cord-028721-x6f26ahr 3201 19 cell cell NN cord-028721-x6f26ahr 3201 20 failure failure NN cord-028721-x6f26ahr 3201 21 , , , cord-028721-x6f26ahr 3201 22 including include VBG cord-028721-x6f26ahr 3201 23 testicular testicular JJ cord-028721-x6f26ahr 3201 24 atrophy atrophy NN cord-028721-x6f26ahr 3201 25 , , , cord-028721-x6f26ahr 3201 26 infertility infertility NN cord-028721-x6f26ahr 3201 27 , , , cord-028721-x6f26ahr 3201 28 decreased decrease VBD cord-028721-x6f26ahr 3201 29 libido libido NN cord-028721-x6f26ahr 3201 30 , , , cord-028721-x6f26ahr 3201 31 impotence impotence NN cord-028721-x6f26ahr 3201 32 , , , cord-028721-x6f26ahr 3201 33 and and CC cord-028721-x6f26ahr 3201 34 reduced reduce VBN cord-028721-x6f26ahr 3201 35 size size NN cord-028721-x6f26ahr 3201 36 of of IN cord-028721-x6f26ahr 3201 37 the the DT cord-028721-x6f26ahr 3201 38 prostate prostate NN cord-028721-x6f26ahr 3201 39 and and CC cord-028721-x6f26ahr 3201 40 seminal seminal JJ cord-028721-x6f26ahr 3201 41 vesicles vesicle NNS cord-028721-x6f26ahr 3201 42 . . . cord-028721-x6f26ahr 3202 1 1340 1340 CD cord-028721-x6f26ahr 3202 2 Chronic chronic JJ cord-028721-x6f26ahr 3202 3 alcoholic alcoholic JJ cord-028721-x6f26ahr 3202 4 patients patient NNS cord-028721-x6f26ahr 3202 5 with with IN cord-028721-x6f26ahr 3202 6 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3202 7 also also RB cord-028721-x6f26ahr 3202 8 have have VBP cord-028721-x6f26ahr 3202 9 symptoms symptom NNS cord-028721-x6f26ahr 3202 10 of of IN cord-028721-x6f26ahr 3202 11 hyperestrogenism hyperestrogenism NN cord-028721-x6f26ahr 3202 12 , , , cord-028721-x6f26ahr 3202 13 including include VBG cord-028721-x6f26ahr 3202 14 gynecomastia gynecomastia NN cord-028721-x6f26ahr 3202 15 , , , cord-028721-x6f26ahr 3202 16 female female JJ cord-028721-x6f26ahr 3202 17 escutcheon escutcheon NN cord-028721-x6f26ahr 3202 18 , , , cord-028721-x6f26ahr 3202 19 and and CC cord-028721-x6f26ahr 3202 20 female female JJ cord-028721-x6f26ahr 3202 21 fat fat JJ cord-028721-x6f26ahr 3202 22 distribution distribution NN cord-028721-x6f26ahr 3202 23 pattern pattern NN cord-028721-x6f26ahr 3202 24 . . . cord-028721-x6f26ahr 3203 1 Most Most JJS cord-028721-x6f26ahr 3203 2 chronic chronic JJ cord-028721-x6f26ahr 3203 3 alcoholic alcoholic JJ cord-028721-x6f26ahr 3203 4 men man NNS cord-028721-x6f26ahr 3203 5 , , , cord-028721-x6f26ahr 3203 6 with with IN cord-028721-x6f26ahr 3203 7 or or CC cord-028721-x6f26ahr 3203 8 without without IN cord-028721-x6f26ahr 3203 9 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3203 10 , , , cord-028721-x6f26ahr 3203 11 have have VBP cord-028721-x6f26ahr 3203 12 signifi signifi NNP cord-028721-x6f26ahr 3203 13 ca can MD cord-028721-x6f26ahr 3203 14 nt not RB cord-028721-x6f26ahr 3203 15 testicular testicular JJ cord-028721-x6f26ahr 3203 16 lesions lesion NNS cord-028721-x6f26ahr 3203 17 . . . cord-028721-x6f26ahr 3204 1 The the DT cord-028721-x6f26ahr 3204 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 3204 3 tubules tubule NNS cord-028721-x6f26ahr 3204 4 have have VBP cord-028721-x6f26ahr 3204 5 reduced reduce VBN cord-028721-x6f26ahr 3204 6 diameters diameter NNS cord-028721-x6f26ahr 3204 7 , , , cord-028721-x6f26ahr 3204 8 thickened thicken VBN cord-028721-x6f26ahr 3204 9 lamina lamina NN cord-028721-x6f26ahr 3204 10 propria propria NN cord-028721-x6f26ahr 3204 11 , , , cord-028721-x6f26ahr 3204 12 and and CC cord-028721-x6f26ahr 3204 13 decreased decrease VBD cord-028721-x6f26ahr 3204 14 or or CC cord-028721-x6f26ahr 3204 15 absent absent JJ cord-028721-x6f26ahr 3204 16 germ germ NN cord-028721-x6f26ahr 3204 17 cells cell NNS cord-028721-x6f26ahr 3204 18 . . . cord-028721-x6f26ahr 3205 1 Leydig leydig NN cord-028721-x6f26ahr 3205 2 cells cell NNS cord-028721-x6f26ahr 3205 3 are be VBP cord-028721-x6f26ahr 3205 4 reduced reduce VBN cord-028721-x6f26ahr 3205 5 in in IN cord-028721-x6f26ahr 3205 6 number number NN cord-028721-x6f26ahr 3205 7 and and CC cord-028721-x6f26ahr 3205 8 contain contain VB cord-028721-x6f26ahr 3205 9 abundant abundant JJ cord-028721-x6f26ahr 3205 10 lipofuscin lipofuscin NNS cord-028721-x6f26ahr 3205 11 granules granule NNS cord-028721-x6f26ahr 3205 12 ( ( -LRB- cord-028721-x6f26ahr 3205 13 Fig Fig NNP cord-028721-x6f26ahr 3205 14 . . . cord-028721-x6f26ahr 3205 15 12 12 CD cord-028721-x6f26ahr 3205 16 - - SYM cord-028721-x6f26ahr 3205 17 146 146 CD cord-028721-x6f26ahr 3205 18 ) ) -RRB- cord-028721-x6f26ahr 3205 19 . . . cord-028721-x6f26ahr 3206 1 The the DT cord-028721-x6f26ahr 3206 2 epididymis epididymis NN cord-028721-x6f26ahr 3206 3 becomes become VBZ cord-028721-x6f26ahr 3206 4 atrophic atrophic JJ cord-028721-x6f26ahr 3206 5 , , , cord-028721-x6f26ahr 3206 6 mainly mainly RB cord-028721-x6f26ahr 3206 7 in in IN cord-028721-x6f26ahr 3206 8 the the DT cord-028721-x6f26ahr 3206 9 ductuli ductuli NNP cord-028721-x6f26ahr 3206 10 efferentes efferentes NNP cord-028721-x6f26ahr 3206 11 , , , cord-028721-x6f26ahr 3206 12 owing owe VBG cord-028721-x6f26ahr 3206 13 to to IN cord-028721-x6f26ahr 3206 14 androgen androgen NN cord-028721-x6f26ahr 3206 15 deprivation deprivation NN cord-028721-x6f26ahr 3206 16 . . . cord-028721-x6f26ahr 3207 1 The the DT cord-028721-x6f26ahr 3207 2 epithelium epithelium NN cord-028721-x6f26ahr 3207 3 of of IN cord-028721-x6f26ahr 3207 4 the the DT cord-028721-x6f26ahr 3207 5 rete rete NN cord-028721-x6f26ahr 3207 6 testis testis NN cord-028721-x6f26ahr 3207 7 becomes become VBZ cord-028721-x6f26ahr 3207 8 cuboidal cuboidal JJ cord-028721-x6f26ahr 3207 9 or or CC cord-028721-x6f26ahr 3207 10 columnar columnar JJ cord-028721-x6f26ahr 3207 11 due due IN cord-028721-x6f26ahr 3207 12 to to IN cord-028721-x6f26ahr 3207 13 estrogens estrogen NNS cord-028721-x6f26ahr 3207 14 . . . cord-028721-x6f26ahr 3208 1 The the DT cord-028721-x6f26ahr 3208 2 spermiogram spermiogram NNP cord-028721-x6f26ahr 3208 3 correlates correlate VBZ cord-028721-x6f26ahr 3208 4 with with IN cord-028721-x6f26ahr 3208 5 the the DT cord-028721-x6f26ahr 3208 6 variability variability NN cord-028721-x6f26ahr 3208 7 of of IN cord-028721-x6f26ahr 3208 8 histologic histologic JJ cord-028721-x6f26ahr 3208 9 fi fi NN cord-028721-x6f26ahr 3208 10 ndings nding NNS cord-028721-x6f26ahr 3208 11 , , , cord-028721-x6f26ahr 3208 12 usually usually RB cord-028721-x6f26ahr 3208 13 showing show VBG cord-028721-x6f26ahr 3208 14 a a DT cord-028721-x6f26ahr 3208 15 marked marked JJ cord-028721-x6f26ahr 3208 16 reduction reduction NN cord-028721-x6f26ahr 3208 17 in in IN cord-028721-x6f26ahr 3208 18 the the DT cord-028721-x6f26ahr 3208 19 number number NN cord-028721-x6f26ahr 3208 20 and and CC cord-028721-x6f26ahr 3208 21 motility motility NN cord-028721-x6f26ahr 3208 22 of of IN cord-028721-x6f26ahr 3208 23 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3208 24 and and CC cord-028721-x6f26ahr 3208 25 an an DT cord-028721-x6f26ahr 3208 26 increase increase NN cord-028721-x6f26ahr 3208 27 in in IN cord-028721-x6f26ahr 3208 28 the the DT cord-028721-x6f26ahr 3208 29 percentage percentage NN cord-028721-x6f26ahr 3208 30 of of IN cord-028721-x6f26ahr 3208 31 morphologically morphologically RB cord-028721-x6f26ahr 3208 32 abnormal abnormal JJ cord-028721-x6f26ahr 3208 33 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3208 34 . . . cord-028721-x6f26ahr 3209 1 1341 1341 CD cord-028721-x6f26ahr 3209 2 , , , cord-028721-x6f26ahr 3209 3 1342 1342 CD cord-028721-x6f26ahr 3209 4 About about IN cord-028721-x6f26ahr 3209 5 20 20 CD cord-028721-x6f26ahr 3209 6 % % NN cord-028721-x6f26ahr 3209 7 of of IN cord-028721-x6f26ahr 3209 8 patients patient NNS cord-028721-x6f26ahr 3209 9 initially initially RB cord-028721-x6f26ahr 3209 10 have have VBP cord-028721-x6f26ahr 3209 11 an an DT cord-028721-x6f26ahr 3209 12 increase increase NN cord-028721-x6f26ahr 3209 13 in in IN cord-028721-x6f26ahr 3209 14 serum serum NN cord-028721-x6f26ahr 3209 15 testosterone testosterone NN cord-028721-x6f26ahr 3209 16 ; ; : cord-028721-x6f26ahr 3209 17 with with IN cord-028721-x6f26ahr 3209 18 advanced advanced JJ cord-028721-x6f26ahr 3209 19 disease disease NN cord-028721-x6f26ahr 3209 20 , , , cord-028721-x6f26ahr 3209 21 testosterone testosterone NN cord-028721-x6f26ahr 3209 22 level level NN cord-028721-x6f26ahr 3209 23 decreases decrease NNS cord-028721-x6f26ahr 3209 24 . . . cord-028721-x6f26ahr 3210 1 The the DT cord-028721-x6f26ahr 3210 2 initial initial JJ cord-028721-x6f26ahr 3210 3 increase increase NN cord-028721-x6f26ahr 3210 4 is be VBZ cord-028721-x6f26ahr 3210 5 due due JJ cord-028721-x6f26ahr 3210 6 to to IN cord-028721-x6f26ahr 3210 7 an an DT cord-028721-x6f26ahr 3210 8 elevation elevation NN cord-028721-x6f26ahr 3210 9 in in IN cord-028721-x6f26ahr 3210 10 sex sex NN cord-028721-x6f26ahr 3210 11 hormone hormone NN cord-028721-x6f26ahr 3210 12 - - HYPH cord-028721-x6f26ahr 3210 13 binding bind VBG cord-028721-x6f26ahr 3210 14 globulin globulin NN cord-028721-x6f26ahr 3210 15 concentration concentration NN cord-028721-x6f26ahr 3210 16 and and CC cord-028721-x6f26ahr 3210 17 reduced reduce VBN cord-028721-x6f26ahr 3210 18 testosterone testosterone NN cord-028721-x6f26ahr 3210 19 metabolism metabolism NN cord-028721-x6f26ahr 3210 20 by by IN cord-028721-x6f26ahr 3210 21 the the DT cord-028721-x6f26ahr 3210 22 liver liver NN cord-028721-x6f26ahr 3210 23 . . . cord-028721-x6f26ahr 3211 1 1343 1343 CD cord-028721-x6f26ahr 3211 2 Serum serum NN cord-028721-x6f26ahr 3211 3 estrogen estrogen NN cord-028721-x6f26ahr 3211 4 level level NN cord-028721-x6f26ahr 3211 5 also also RB cord-028721-x6f26ahr 3211 6 increases increase VBZ cord-028721-x6f26ahr 3211 7 owing owe VBG cord-028721-x6f26ahr 3211 8 to to IN cord-028721-x6f26ahr 3211 9 increased increase VBN cord-028721-x6f26ahr 3211 10 conversion conversion NN cord-028721-x6f26ahr 3211 11 of of IN cord-028721-x6f26ahr 3211 12 testos testos NN cord-028721-x6f26ahr 3211 13 - - HYPH cord-028721-x6f26ahr 3211 14 terone terone NN cord-028721-x6f26ahr 3211 15 into into IN cord-028721-x6f26ahr 3211 16 estrogen estrogen NN cord-028721-x6f26ahr 3211 17 in in IN cord-028721-x6f26ahr 3211 18 peripheral peripheral JJ cord-028721-x6f26ahr 3211 19 adipose adipose JJ cord-028721-x6f26ahr 3211 20 and and CC cord-028721-x6f26ahr 3211 21 muscular muscular JJ cord-028721-x6f26ahr 3211 22 tissue tissue NN cord-028721-x6f26ahr 3211 23 . . . cord-028721-x6f26ahr 3212 1 1344 1344 CD cord-028721-x6f26ahr 3212 2 _SP cord-028721-x6f26ahr 3213 1 Non non JJ cord-028721-x6f26ahr 3213 2 - - JJ cord-028721-x6f26ahr 3213 3 alcoholic alcoholic JJ cord-028721-x6f26ahr 3213 4 liver liver NN cord-028721-x6f26ahr 3213 5 disease disease NN cord-028721-x6f26ahr 3213 6 impairs impair VBZ cord-028721-x6f26ahr 3213 7 gonadal gonadal JJ cord-028721-x6f26ahr 3213 8 function function NN cord-028721-x6f26ahr 3213 9 according accord VBG cord-028721-x6f26ahr 3213 10 to to IN cord-028721-x6f26ahr 3213 11 the the DT cord-028721-x6f26ahr 3213 12 severity severity NN cord-028721-x6f26ahr 3213 13 of of IN cord-028721-x6f26ahr 3213 14 the the DT cord-028721-x6f26ahr 3213 15 disease disease NN cord-028721-x6f26ahr 3213 16 . . . cord-028721-x6f26ahr 3214 1 1345 1345 CD cord-028721-x6f26ahr 3214 2 Patients patient NNS cord-028721-x6f26ahr 3214 3 have have VBP cord-028721-x6f26ahr 3214 4 decreased decrease VBN cord-028721-x6f26ahr 3214 5 levels level NNS cord-028721-x6f26ahr 3214 6 of of IN cord-028721-x6f26ahr 3214 7 total total NN cord-028721-x6f26ahr 3214 8 and and CC cord-028721-x6f26ahr 3214 9 biologically biologically RB cord-028721-x6f26ahr 3214 10 active active JJ cord-028721-x6f26ahr 3214 11 free free JJ cord-028721-x6f26ahr 3214 12 testosterone testosterone NN cord-028721-x6f26ahr 3214 13 . . . cord-028721-x6f26ahr 3215 1 Hormonal hormonal JJ cord-028721-x6f26ahr 3215 2 alterations alteration NNS cord-028721-x6f26ahr 3215 3 are be VBP cord-028721-x6f26ahr 3215 4 not not RB cord-028721-x6f26ahr 3215 5 as as RB cord-028721-x6f26ahr 3215 6 severe severe JJ cord-028721-x6f26ahr 3215 7 as as IN cord-028721-x6f26ahr 3215 8 in in IN cord-028721-x6f26ahr 3215 9 alcoholic alcoholic JJ cord-028721-x6f26ahr 3215 10 patients patient NNS cord-028721-x6f26ahr 3215 11 , , , cord-028721-x6f26ahr 3215 12 emphasizing emphasize VBG cord-028721-x6f26ahr 3215 13 the the DT cord-028721-x6f26ahr 3215 14 direct direct JJ cord-028721-x6f26ahr 3215 15 action action NN cord-028721-x6f26ahr 3215 16 of of IN cord-028721-x6f26ahr 3215 17 alcohol alcohol NN cord-028721-x6f26ahr 3215 18 on on IN cord-028721-x6f26ahr 3215 19 Leydig Leydig NNP cord-028721-x6f26ahr 3215 20 cells cell NNS cord-028721-x6f26ahr 3215 21 . . . cord-028721-x6f26ahr 3216 1 In in IN cord-028721-x6f26ahr 3216 2 α α NN cord-028721-x6f26ahr 3216 3 1 1 CD cord-028721-x6f26ahr 3216 4 -antitrypsin -antitrypsin NNP cord-028721-x6f26ahr 3216 5 defi defi NNP cord-028721-x6f26ahr 3216 6 ciency ciency NNP cord-028721-x6f26ahr 3216 7 testicular testicular NNP cord-028721-x6f26ahr 3216 8 function function NN cord-028721-x6f26ahr 3216 9 and and CC cord-028721-x6f26ahr 3216 10 fertility fertility NN cord-028721-x6f26ahr 3216 11 are be VBP cord-028721-x6f26ahr 3216 12 conserved conserve VBN cord-028721-x6f26ahr 3216 13 ; ; : cord-028721-x6f26ahr 3216 14 only only RB cord-028721-x6f26ahr 3216 15 in in IN cord-028721-x6f26ahr 3216 16 advanced advanced JJ cord-028721-x6f26ahr 3216 17 stages stage NNS cord-028721-x6f26ahr 3216 18 of of IN cord-028721-x6f26ahr 3216 19 the the DT cord-028721-x6f26ahr 3216 20 disease disease NN cord-028721-x6f26ahr 3216 21 do do VBP cord-028721-x6f26ahr 3216 22 minor minor JJ cord-028721-x6f26ahr 3216 23 biochemical biochemical JJ cord-028721-x6f26ahr 3216 24 alterations alteration NNS cord-028721-x6f26ahr 3216 25 occur occur VBP cord-028721-x6f26ahr 3216 26 . . . cord-028721-x6f26ahr 3217 1 1346 1346 CD cord-028721-x6f26ahr 3218 1 In in IN cord-028721-x6f26ahr 3218 2 Alagille Alagille NNP cord-028721-x6f26ahr 3218 3 's 's POS cord-028721-x6f26ahr 3218 4 syndrome syndrome NN cord-028721-x6f26ahr 3218 5 ( ( -LRB- cord-028721-x6f26ahr 3218 6 intrahepatic intrahepatic JJ cord-028721-x6f26ahr 3218 7 biliary biliary JJ cord-028721-x6f26ahr 3218 8 duct duct NN cord-028721-x6f26ahr 3218 9 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3218 10 ) ) -RRB- cord-028721-x6f26ahr 3218 11 , , , cord-028721-x6f26ahr 3218 12 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3218 13 is be VBZ cord-028721-x6f26ahr 3218 14 associated associate VBN cord-028721-x6f26ahr 3218 15 with with IN cord-028721-x6f26ahr 3218 16 cholestasis cholestasis NN cord-028721-x6f26ahr 3218 17 , , , cord-028721-x6f26ahr 3218 18 frequent frequent JJ cord-028721-x6f26ahr 3218 19 vertebral vertebral JJ cord-028721-x6f26ahr 3218 20 , , , cord-028721-x6f26ahr 3218 21 cardiac cardiac NN cord-028721-x6f26ahr 3218 22 , , , cord-028721-x6f26ahr 3218 23 and and CC cord-028721-x6f26ahr 3218 24 facial facial JJ cord-028721-x6f26ahr 3218 25 malformations malformation NNS cord-028721-x6f26ahr 3218 26 , , , cord-028721-x6f26ahr 3218 27 and and CC cord-028721-x6f26ahr 3218 28 mental mental JJ cord-028721-x6f26ahr 3218 29 retardation retardation NN cord-028721-x6f26ahr 3218 30 . . . cord-028721-x6f26ahr 3219 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3219 2 is be VBZ cord-028721-x6f26ahr 3219 3 manifest manifest JJ cord-028721-x6f26ahr 3219 4 by by IN cord-028721-x6f26ahr 3219 5 small small JJ cord-028721-x6f26ahr 3219 6 testes testis NNS cord-028721-x6f26ahr 3219 7 , , , cord-028721-x6f26ahr 3219 8 delayed delay VBN cord-028721-x6f26ahr 3219 9 puberty puberty NN cord-028721-x6f26ahr 3219 10 , , , cord-028721-x6f26ahr 3219 11 and and CC cord-028721-x6f26ahr 3219 12 , , , cord-028721-x6f26ahr 3219 13 in in IN cord-028721-x6f26ahr 3219 14 adults adult NNS cord-028721-x6f26ahr 3219 15 , , , cord-028721-x6f26ahr 3219 16 lack lack NN cord-028721-x6f26ahr 3219 17 of of IN cord-028721-x6f26ahr 3219 18 germ germ NN cord-028721-x6f26ahr 3219 19 cell cell NN cord-028721-x6f26ahr 3219 20 development development NN cord-028721-x6f26ahr 3219 21 . . . cord-028721-x6f26ahr 3220 1 Hereditary hereditary JJ cord-028721-x6f26ahr 3220 2 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3220 3 is be VBZ cord-028721-x6f26ahr 3220 4 the the DT cord-028721-x6f26ahr 3220 5 most most RBS cord-028721-x6f26ahr 3220 6 frequent frequent JJ cord-028721-x6f26ahr 3220 7 genetic genetic JJ cord-028721-x6f26ahr 3220 8 disease disease NN cord-028721-x6f26ahr 3220 9 in in IN cord-028721-x6f26ahr 3220 10 the the DT cord-028721-x6f26ahr 3220 11 northern northern JJ cord-028721-x6f26ahr 3220 12 hemisphere hemisphere NN cord-028721-x6f26ahr 3220 13 and and CC cord-028721-x6f26ahr 3220 14 results result NNS cord-028721-x6f26ahr 3220 15 from from IN cord-028721-x6f26ahr 3220 16 excessive excessive JJ cord-028721-x6f26ahr 3220 17 iron iron NN cord-028721-x6f26ahr 3220 18 absorption absorption NN cord-028721-x6f26ahr 3220 19 and and CC cord-028721-x6f26ahr 3220 20 accumulation accumulation NN cord-028721-x6f26ahr 3220 21 in in IN cord-028721-x6f26ahr 3220 22 multiple multiple JJ cord-028721-x6f26ahr 3220 23 tissue tissue NN cord-028721-x6f26ahr 3220 24 and and CC cord-028721-x6f26ahr 3220 25 organs organ NNS cord-028721-x6f26ahr 3220 26 , , , cord-028721-x6f26ahr 3220 27 leading lead VBG cord-028721-x6f26ahr 3220 28 to to IN cord-028721-x6f26ahr 3220 29 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3220 30 , , , cord-028721-x6f26ahr 3220 31 diabetes diabetes NN cord-028721-x6f26ahr 3220 32 , , , cord-028721-x6f26ahr 3220 33 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3220 34 , , , cord-028721-x6f26ahr 3220 35 and and CC cord-028721-x6f26ahr 3220 36 arthralgia arthralgia NNP cord-028721-x6f26ahr 3220 37 . . . cord-028721-x6f26ahr 3221 1 Four four CD cord-028721-x6f26ahr 3221 2 types type NNS cord-028721-x6f26ahr 3221 3 of of IN cord-028721-x6f26ahr 3221 4 hereditary hereditary JJ cord-028721-x6f26ahr 3221 5 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3221 6 have have VBP cord-028721-x6f26ahr 3221 7 been be VBN cord-028721-x6f26ahr 3221 8 reported report VBN cord-028721-x6f26ahr 3221 9 . . . cord-028721-x6f26ahr 3222 1 1347 1347 CD cord-028721-x6f26ahr 3222 2 Type Type NNP cord-028721-x6f26ahr 3222 3 1 1 CD cord-028721-x6f26ahr 3222 4 , , , cord-028721-x6f26ahr 3222 5 the the DT cord-028721-x6f26ahr 3222 6 most most RBS cord-028721-x6f26ahr 3222 7 frequent frequent JJ cord-028721-x6f26ahr 3222 8 , , , cord-028721-x6f26ahr 3222 9 is be VBZ cord-028721-x6f26ahr 3222 10 caused cause VBN cord-028721-x6f26ahr 3222 11 by by IN cord-028721-x6f26ahr 3222 12 mutation mutation NN cord-028721-x6f26ahr 3222 13 in in IN cord-028721-x6f26ahr 3222 14 the the DT cord-028721-x6f26ahr 3222 15 HFE HFE NNP cord-028721-x6f26ahr 3222 16 gene gene NN cord-028721-x6f26ahr 3222 17 ( ( -LRB- cord-028721-x6f26ahr 3222 18 C282Y C282Y NNP cord-028721-x6f26ahr 3222 19 ) ) -RRB- cord-028721-x6f26ahr 3222 20 , , , cord-028721-x6f26ahr 3222 21 leading lead VBG cord-028721-x6f26ahr 3222 22 to to IN cord-028721-x6f26ahr 3222 23 increased increase VBN cord-028721-x6f26ahr 3222 24 intestinal intestinal JJ cord-028721-x6f26ahr 3222 25 absorption absorption NN cord-028721-x6f26ahr 3222 26 of of IN cord-028721-x6f26ahr 3222 27 iron iron NN cord-028721-x6f26ahr 3222 28 , , , cord-028721-x6f26ahr 3222 29 supersaturation supersaturation NN cord-028721-x6f26ahr 3222 30 of of IN cord-028721-x6f26ahr 3222 31 iron iron NN cord-028721-x6f26ahr 3222 32 deposits deposit NNS cord-028721-x6f26ahr 3222 33 , , , cord-028721-x6f26ahr 3222 34 and and CC cord-028721-x6f26ahr 3222 35 damage damage NN cord-028721-x6f26ahr 3222 36 in in IN cord-028721-x6f26ahr 3222 37 multiples multiple NNS cord-028721-x6f26ahr 3222 38 organs organ NNS cord-028721-x6f26ahr 3222 39 . . . cord-028721-x6f26ahr 3223 1 The the DT cord-028721-x6f26ahr 3223 2 type type NN cord-028721-x6f26ahr 3223 3 I -PRON- PRP cord-028721-x6f26ahr 3223 4 hereditary hereditary JJ cord-028721-x6f26ahr 3223 5 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3223 6 gene gene NN cord-028721-x6f26ahr 3223 7 ( ( -LRB- cord-028721-x6f26ahr 3223 8 HFE HFE NNP cord-028721-x6f26ahr 3223 9 ) ) -RRB- cord-028721-x6f26ahr 3223 10 is be VBZ cord-028721-x6f26ahr 3223 11 located locate VBN cord-028721-x6f26ahr 3223 12 on on IN cord-028721-x6f26ahr 3223 13 the the DT cord-028721-x6f26ahr 3223 14 short short JJ cord-028721-x6f26ahr 3223 15 arm arm NN cord-028721-x6f26ahr 3223 16 of of IN cord-028721-x6f26ahr 3223 17 chromosome chromosome NN cord-028721-x6f26ahr 3223 18 6 6 CD cord-028721-x6f26ahr 3223 19 , , , cord-028721-x6f26ahr 3223 20 1348,1349 1348,1349 NNP cord-028721-x6f26ahr 3223 21 is be VBZ cord-028721-x6f26ahr 3223 22 present present JJ cord-028721-x6f26ahr 3223 23 in in IN cord-028721-x6f26ahr 3223 24 85 85 CD cord-028721-x6f26ahr 3223 25 - - SYM cord-028721-x6f26ahr 3223 26 100 100 CD cord-028721-x6f26ahr 3223 27 % % NN cord-028721-x6f26ahr 3223 28 of of IN cord-028721-x6f26ahr 3223 29 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3223 30 patients patient NNS cord-028721-x6f26ahr 3223 31 with with IN cord-028721-x6f26ahr 3223 32 northern northern JJ cord-028721-x6f26ahr 3223 33 European european JJ cord-028721-x6f26ahr 3223 34 ancestry ancestry NN cord-028721-x6f26ahr 3223 35 , , , cord-028721-x6f26ahr 3223 36 and and CC cord-028721-x6f26ahr 3223 37 its -PRON- PRP$ cord-028721-x6f26ahr 3223 38 protein protein NN cord-028721-x6f26ahr 3223 39 product product NN cord-028721-x6f26ahr 3223 40 is be VBZ cord-028721-x6f26ahr 3223 41 mainly mainly RB cord-028721-x6f26ahr 3223 42 expressed express VBN cord-028721-x6f26ahr 3223 43 in in IN cord-028721-x6f26ahr 3223 44 the the DT cord-028721-x6f26ahr 3223 45 epithelium epithelium NN cord-028721-x6f26ahr 3223 46 of of IN cord-028721-x6f26ahr 3223 47 Lieberkühn Lieberkühn NNP cord-028721-x6f26ahr 3223 48 crypts crypt NNS cord-028721-x6f26ahr 3223 49 . . . cord-028721-x6f26ahr 3224 1 This this DT cord-028721-x6f26ahr 3224 2 protein protein NN cord-028721-x6f26ahr 3224 3 interacts interact VBZ cord-028721-x6f26ahr 3224 4 with with IN cord-028721-x6f26ahr 3224 5 the the DT cord-028721-x6f26ahr 3224 6 transferrin transferrin NN cord-028721-x6f26ahr 3224 7 receptor receptor NN cord-028721-x6f26ahr 3224 8 , , , cord-028721-x6f26ahr 3224 9 reducing reduce VBG cord-028721-x6f26ahr 3224 10 its -PRON- PRP$ cord-028721-x6f26ahr 3224 11 affi affi NNP cord-028721-x6f26ahr 3224 12 nity nity NN cord-028721-x6f26ahr 3224 13 for for IN cord-028721-x6f26ahr 3224 14 iron iron NN cord-028721-x6f26ahr 3224 15 - - HYPH cord-028721-x6f26ahr 3224 16 bound bind VBN cord-028721-x6f26ahr 3224 17 transferrin transferrin NN cord-028721-x6f26ahr 3224 18 ; ; : cord-028721-x6f26ahr 3224 19 therefore therefore RB cord-028721-x6f26ahr 3224 20 , , , cord-028721-x6f26ahr 3224 21 HFE HFE NNP cord-028721-x6f26ahr 3224 22 becomes become VBZ cord-028721-x6f26ahr 3224 23 a a DT cord-028721-x6f26ahr 3224 24 negative negative JJ cord-028721-x6f26ahr 3224 25 regulator regulator NN cord-028721-x6f26ahr 3224 26 of of IN cord-028721-x6f26ahr 3224 27 transferrinbound transferrinbound JJ cord-028721-x6f26ahr 3224 28 iron iron NN cord-028721-x6f26ahr 3224 29 uptake uptake NN cord-028721-x6f26ahr 3224 30 . . . cord-028721-x6f26ahr 3225 1 Type type NN cord-028721-x6f26ahr 3225 2 2 2 CD cord-028721-x6f26ahr 3225 3 gene gene NN cord-028721-x6f26ahr 3225 4 is be VBZ cord-028721-x6f26ahr 3225 5 a a DT cord-028721-x6f26ahr 3225 6 juvenile juvenile JJ cord-028721-x6f26ahr 3225 7 form form NN cord-028721-x6f26ahr 3225 8 that that WDT cord-028721-x6f26ahr 3225 9 expresses express VBZ cord-028721-x6f26ahr 3225 10 before before IN cord-028721-x6f26ahr 3225 11 the the DT cord-028721-x6f26ahr 3225 12 age age NN cord-028721-x6f26ahr 3225 13 of of IN cord-028721-x6f26ahr 3225 14 30 30 CD cord-028721-x6f26ahr 3225 15 years year NNS cord-028721-x6f26ahr 3225 16 in in IN cord-028721-x6f26ahr 3225 17 both both DT cord-028721-x6f26ahr 3225 18 sexes sex NNS cord-028721-x6f26ahr 3225 19 , , , cord-028721-x6f26ahr 3225 20 and and CC cord-028721-x6f26ahr 3225 21 is be VBZ cord-028721-x6f26ahr 3225 22 associated associate VBN cord-028721-x6f26ahr 3225 23 with with IN cord-028721-x6f26ahr 3225 24 severe severe JJ cord-028721-x6f26ahr 3225 25 cardiomyopathy cardiomyopathy NN cord-028721-x6f26ahr 3225 26 and and CC cord-028721-x6f26ahr 3225 27 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3225 28 . . . cord-028721-x6f26ahr 3226 1 1350 1350 CD cord-028721-x6f26ahr 3227 1 The the DT cord-028721-x6f26ahr 3227 2 type type NN cord-028721-x6f26ahr 3227 3 2 2 CD cord-028721-x6f26ahr 3227 4 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3227 5 locus locus NN cord-028721-x6f26ahr 3227 6 is be VBZ cord-028721-x6f26ahr 3227 7 on on IN cord-028721-x6f26ahr 3227 8 chromosome chromosome NN cord-028721-x6f26ahr 3227 9 1q21 1q21 CD cord-028721-x6f26ahr 3227 10 , , , cord-028721-x6f26ahr 3227 11 but but CC cord-028721-x6f26ahr 3227 12 this this DT cord-028721-x6f26ahr 3227 13 gene gene NN cord-028721-x6f26ahr 3227 14 has have VBZ cord-028721-x6f26ahr 3227 15 not not RB cord-028721-x6f26ahr 3227 16 yet yet RB cord-028721-x6f26ahr 3227 17 been be VBN cord-028721-x6f26ahr 3227 18 isolated isolate VBN cord-028721-x6f26ahr 3227 19 . . . cord-028721-x6f26ahr 3228 1 1351 1351 CD cord-028721-x6f26ahr 3228 2 , , , cord-028721-x6f26ahr 3228 3 1352 1352 CD cord-028721-x6f26ahr 3228 4 Type Type NNP cord-028721-x6f26ahr 3228 5 3 3 CD cord-028721-x6f26ahr 3228 6 is be VBZ cord-028721-x6f26ahr 3228 7 on on IN cord-028721-x6f26ahr 3228 8 chromosome chromosome NN cord-028721-x6f26ahr 3228 9 7q22 7q22 CD cord-028721-x6f26ahr 3228 10 , , , cord-028721-x6f26ahr 3228 11 impairs impair VBZ cord-028721-x6f26ahr 3228 12 the the DT cord-028721-x6f26ahr 3228 13 transferrin transferrin NN cord-028721-x6f26ahr 3228 14 2 2 CD cord-028721-x6f26ahr 3228 15 receptor receptor NN cord-028721-x6f26ahr 3228 16 , , , cord-028721-x6f26ahr 3228 17 and and CC cord-028721-x6f26ahr 3228 18 its -PRON- PRP$ cord-028721-x6f26ahr 3228 19 consequences consequence NNS cord-028721-x6f26ahr 3228 20 are be VBP cord-028721-x6f26ahr 3228 21 similar similar JJ cord-028721-x6f26ahr 3228 22 to to IN cord-028721-x6f26ahr 3228 23 those those DT cord-028721-x6f26ahr 3228 24 of of IN cord-028721-x6f26ahr 3228 25 type type NN cord-028721-x6f26ahr 3228 26 1 1 CD cord-028721-x6f26ahr 3228 27 receptor receptor NN cord-028721-x6f26ahr 3228 28 defect defect NN cord-028721-x6f26ahr 3228 29 . . . cord-028721-x6f26ahr 3229 1 Type type NN cord-028721-x6f26ahr 3229 2 4 4 CD cord-028721-x6f26ahr 3229 3 is be VBZ cord-028721-x6f26ahr 3229 4 autosomal autosomal JJ cord-028721-x6f26ahr 3229 5 dominant dominant JJ cord-028721-x6f26ahr 3229 6 , , , cord-028721-x6f26ahr 3229 7 on on IN cord-028721-x6f26ahr 3229 8 2q32 2q32 CD cord-028721-x6f26ahr 3229 9 , , , cord-028721-x6f26ahr 3229 10 and and CC cord-028721-x6f26ahr 3229 11 affects affect VBZ cord-028721-x6f26ahr 3229 12 the the DT cord-028721-x6f26ahr 3229 13 basolateral basolateral JJ cord-028721-x6f26ahr 3229 14 iron iron NN cord-028721-x6f26ahr 3229 15 carrier carrier NN cord-028721-x6f26ahr 3229 16 ferroportin ferroportin NNP cord-028721-x6f26ahr 3229 17 1 1 CD cord-028721-x6f26ahr 3229 18 , , , cord-028721-x6f26ahr 3229 19 resulting result VBG cord-028721-x6f26ahr 3229 20 in in IN cord-028721-x6f26ahr 3229 21 iron iron NN cord-028721-x6f26ahr 3229 22 deposition deposition NN cord-028721-x6f26ahr 3229 23 in in IN cord-028721-x6f26ahr 3229 24 macrophages macrophage NNS cord-028721-x6f26ahr 3229 25 . . . cord-028721-x6f26ahr 3230 1 Types type NNS cord-028721-x6f26ahr 3230 2 1 1 CD cord-028721-x6f26ahr 3230 3 , , , cord-028721-x6f26ahr 3230 4 2 2 CD cord-028721-x6f26ahr 3230 5 , , , cord-028721-x6f26ahr 3230 6 and and CC cord-028721-x6f26ahr 3230 7 3 3 CD cord-028721-x6f26ahr 3230 8 have have VBP cord-028721-x6f26ahr 3230 9 recessive recessive JJ cord-028721-x6f26ahr 3230 10 autosomal autosomal JJ cord-028721-x6f26ahr 3230 11 inheritance inheritance NN cord-028721-x6f26ahr 3230 12 and and CC cord-028721-x6f26ahr 3230 13 show show VBP cord-028721-x6f26ahr 3230 14 a a DT cord-028721-x6f26ahr 3230 15 similar similar JJ cord-028721-x6f26ahr 3230 16 distribution distribution NN cord-028721-x6f26ahr 3230 17 pattern pattern NN cord-028721-x6f26ahr 3230 18 of of IN cord-028721-x6f26ahr 3230 19 iron iron NN cord-028721-x6f26ahr 3230 20 deposits deposit NNS cord-028721-x6f26ahr 3230 21 . . . cord-028721-x6f26ahr 3231 1 In in IN cord-028721-x6f26ahr 3231 2 these these DT cord-028721-x6f26ahr 3231 3 three three CD cord-028721-x6f26ahr 3231 4 types type NNS cord-028721-x6f26ahr 3231 5 , , , cord-028721-x6f26ahr 3231 6 alteration alteration NN cord-028721-x6f26ahr 3231 7 of of IN cord-028721-x6f26ahr 3231 8 gonadal gonadal JJ cord-028721-x6f26ahr 3231 9 function function NN cord-028721-x6f26ahr 3231 10 has have VBZ cord-028721-x6f26ahr 3231 11 also also RB cord-028721-x6f26ahr 3231 12 been be VBN cord-028721-x6f26ahr 3231 13 reported report VBN cord-028721-x6f26ahr 3231 14 . . . cord-028721-x6f26ahr 3232 1 Iron iron NN cord-028721-x6f26ahr 3232 2 homeostasis homeostasis NN cord-028721-x6f26ahr 3232 3 depends depend VBZ cord-028721-x6f26ahr 3232 4 on on IN cord-028721-x6f26ahr 3232 5 many many JJ cord-028721-x6f26ahr 3232 6 genes gene NNS cord-028721-x6f26ahr 3232 7 that that WDT cord-028721-x6f26ahr 3232 8 act act VBP cord-028721-x6f26ahr 3232 9 in in IN cord-028721-x6f26ahr 3232 10 a a DT cord-028721-x6f26ahr 3232 11 coordinated coordinated JJ cord-028721-x6f26ahr 3232 12 manner manner NN cord-028721-x6f26ahr 3232 13 , , , cord-028721-x6f26ahr 3232 14 and and CC cord-028721-x6f26ahr 3232 15 their -PRON- PRP$ cord-028721-x6f26ahr 3232 16 exact exact JJ cord-028721-x6f26ahr 3232 17 function function NN cord-028721-x6f26ahr 3232 18 is be VBZ cord-028721-x6f26ahr 3232 19 not not RB cord-028721-x6f26ahr 3232 20 well well RB cord-028721-x6f26ahr 3232 21 known known JJ cord-028721-x6f26ahr 3232 22 . . . cord-028721-x6f26ahr 3233 1 It -PRON- PRP cord-028721-x6f26ahr 3233 2 is be VBZ cord-028721-x6f26ahr 3233 3 assumed assume VBN cord-028721-x6f26ahr 3233 4 that that IN cord-028721-x6f26ahr 3233 5 normal normal JJ cord-028721-x6f26ahr 3233 6 individuals individual NNS cord-028721-x6f26ahr 3233 7 absorb absorb VBP cord-028721-x6f26ahr 3233 8 1 1 CD cord-028721-x6f26ahr 3233 9 - - SYM cord-028721-x6f26ahr 3233 10 2 2 CD cord-028721-x6f26ahr 3233 11 mg mg NNP cord-028721-x6f26ahr 3233 12 / / SYM cord-028721-x6f26ahr 3233 13 day day NN cord-028721-x6f26ahr 3233 14 of of IN cord-028721-x6f26ahr 3233 15 iron iron NN cord-028721-x6f26ahr 3233 16 , , , cord-028721-x6f26ahr 3233 17 whereas whereas IN cord-028721-x6f26ahr 3233 18 homozygous homozygous JJ cord-028721-x6f26ahr 3233 19 patients patient NNS cord-028721-x6f26ahr 3233 20 with with IN cord-028721-x6f26ahr 3233 21 hereditary hereditary JJ cord-028721-x6f26ahr 3233 22 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 3233 23 absorb absorb VB cord-028721-x6f26ahr 3233 24 up up IN cord-028721-x6f26ahr 3233 25 to to TO cord-028721-x6f26ahr 3233 26 3 3 CD cord-028721-x6f26ahr 3233 27 - - SYM cord-028721-x6f26ahr 3233 28 4 4 CD cord-028721-x6f26ahr 3233 29 mg mg NNP cord-028721-x6f26ahr 3233 30 / / SYM cord-028721-x6f26ahr 3233 31 day day NN cord-028721-x6f26ahr 3233 32 . . . cord-028721-x6f26ahr 3234 1 Once once IN cord-028721-x6f26ahr 3234 2 iron iron NN cord-028721-x6f26ahr 3234 3 deposits deposit NNS cord-028721-x6f26ahr 3234 4 become become VBP cord-028721-x6f26ahr 3234 5 saturated saturated JJ cord-028721-x6f26ahr 3234 6 ( ( -LRB- cord-028721-x6f26ahr 3234 7 cells cell NNS cord-028721-x6f26ahr 3234 8 of of IN cord-028721-x6f26ahr 3234 9 liver liver NN cord-028721-x6f26ahr 3234 10 , , , cord-028721-x6f26ahr 3234 11 pancreas pancrea NNS cord-028721-x6f26ahr 3234 12 , , , cord-028721-x6f26ahr 3234 13 hypophysis hypophysis NN cord-028721-x6f26ahr 3234 14 , , , cord-028721-x6f26ahr 3234 15 heart heart NN cord-028721-x6f26ahr 3234 16 , , , cord-028721-x6f26ahr 3234 17 adrenals adrenal NNS cord-028721-x6f26ahr 3234 18 , , , cord-028721-x6f26ahr 3234 19 and and CC cord-028721-x6f26ahr 3234 20 gastric gastric JJ cord-028721-x6f26ahr 3234 21 mucosa mucosa NN cord-028721-x6f26ahr 3234 22 ) ) -RRB- cord-028721-x6f26ahr 3234 23 , , , cord-028721-x6f26ahr 3234 24 the the DT cord-028721-x6f26ahr 3234 25 toxic toxic JJ cord-028721-x6f26ahr 3234 26 effects effect NNS cord-028721-x6f26ahr 3234 27 of of IN cord-028721-x6f26ahr 3234 28 iron iron NN cord-028721-x6f26ahr 3234 29 cause cause NN cord-028721-x6f26ahr 3234 30 dysfunction dysfunction NN cord-028721-x6f26ahr 3234 31 of of IN cord-028721-x6f26ahr 3234 32 the the DT cord-028721-x6f26ahr 3234 33 liver liver NN cord-028721-x6f26ahr 3234 34 ( ( -LRB- cord-028721-x6f26ahr 3234 35 cirrhosis cirrhosis NN cord-028721-x6f26ahr 3234 36 and and CC cord-028721-x6f26ahr 3234 37 cancer cancer NN cord-028721-x6f26ahr 3234 38 in in IN cord-028721-x6f26ahr 3234 39 5 5 CD cord-028721-x6f26ahr 3234 40 - - SYM cord-028721-x6f26ahr 3234 41 10 10 CD cord-028721-x6f26ahr 3234 42 % % NN cord-028721-x6f26ahr 3234 43 of of IN cord-028721-x6f26ahr 3234 44 patients patient NNS cord-028721-x6f26ahr 3234 45 ) ) -RRB- cord-028721-x6f26ahr 3234 46 , , , cord-028721-x6f26ahr 3234 47 the the DT cord-028721-x6f26ahr 3234 48 pancreas pancrea NNS cord-028721-x6f26ahr 3234 49 ( ( -LRB- cord-028721-x6f26ahr 3234 50 diabetes diabetes NN cord-028721-x6f26ahr 3234 51 in in IN cord-028721-x6f26ahr 3234 52 80 80 CD cord-028721-x6f26ahr 3234 53 % % NN cord-028721-x6f26ahr 3234 54 of of IN cord-028721-x6f26ahr 3234 55 patients patient NNS cord-028721-x6f26ahr 3234 56 ) ) -RRB- cord-028721-x6f26ahr 3234 57 , , , cord-028721-x6f26ahr 3234 58 the the DT cord-028721-x6f26ahr 3234 59 heart heart NN cord-028721-x6f26ahr 3234 60 ( ( -LRB- cord-028721-x6f26ahr 3234 61 myocardiopathy myocardiopathy NNP cord-028721-x6f26ahr 3234 62 ) ) -RRB- cord-028721-x6f26ahr 3234 63 , , , cord-028721-x6f26ahr 3234 64 musculoskeletal musculoskeletal JJ cord-028721-x6f26ahr 3234 65 system system NN cord-028721-x6f26ahr 3234 66 ( ( -LRB- cord-028721-x6f26ahr 3234 67 arthritis arthritis NN cord-028721-x6f26ahr 3234 68 ) ) -RRB- cord-028721-x6f26ahr 3234 69 , , , cord-028721-x6f26ahr 3234 70 and and CC cord-028721-x6f26ahr 3234 71 hypophysis hypophysis NNP cord-028721-x6f26ahr 3234 72 ( ( -LRB- cord-028721-x6f26ahr 3234 73 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3234 74 ) ) -RRB- cord-028721-x6f26ahr 3235 1 ( ( -LRB- cord-028721-x6f26ahr 3235 2 Fig Fig NNP cord-028721-x6f26ahr 3235 3 . . . cord-028721-x6f26ahr 3235 4 _SP cord-028721-x6f26ahr 3235 5 12 12 CD cord-028721-x6f26ahr 3235 6 - - SYM cord-028721-x6f26ahr 3235 7 147 147 CD cord-028721-x6f26ahr 3235 8 ) ) -RRB- cord-028721-x6f26ahr 3235 9 . . . cord-028721-x6f26ahr 3235 10 _SP cord-028721-x6f26ahr 3236 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3236 2 may may MD cord-028721-x6f26ahr 3236 3 be be VB cord-028721-x6f26ahr 3236 4 the the DT cord-028721-x6f26ahr 3236 5 fi fi NN cord-028721-x6f26ahr 3236 6 rst rst NN cord-028721-x6f26ahr 3236 7 sign sign NN cord-028721-x6f26ahr 3236 8 of of IN cord-028721-x6f26ahr 3236 9 disease disease NN cord-028721-x6f26ahr 3236 10 when when WRB cord-028721-x6f26ahr 3236 11 it -PRON- PRP cord-028721-x6f26ahr 3236 12 starts start VBZ cord-028721-x6f26ahr 3236 13 in in IN cord-028721-x6f26ahr 3236 14 adult adult NN cord-028721-x6f26ahr 3236 15 life life NN cord-028721-x6f26ahr 3236 16 . . . cord-028721-x6f26ahr 3237 1 1353 1353 CD cord-028721-x6f26ahr 3238 1 With with IN cord-028721-x6f26ahr 3238 2 age age NN cord-028721-x6f26ahr 3238 3 , , , cord-028721-x6f26ahr 3238 4 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3238 5 becomes become VBZ cord-028721-x6f26ahr 3238 6 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3238 7 , , , cord-028721-x6f26ahr 3238 8 with with IN cord-028721-x6f26ahr 3238 9 low low JJ cord-028721-x6f26ahr 3238 10 serum serum NN cord-028721-x6f26ahr 3238 11 levels level NNS cord-028721-x6f26ahr 3238 12 of of IN cord-028721-x6f26ahr 3238 13 testosterone testosterone NN cord-028721-x6f26ahr 3238 14 , , , cord-028721-x6f26ahr 3238 15 LH LH NNP cord-028721-x6f26ahr 3238 16 , , , cord-028721-x6f26ahr 3238 17 and and CC cord-028721-x6f26ahr 3238 18 FSH fsh NN cord-028721-x6f26ahr 3238 19 in in IN cord-028721-x6f26ahr 3238 20 more more JJR cord-028721-x6f26ahr 3238 21 than than IN cord-028721-x6f26ahr 3238 22 40 40 CD cord-028721-x6f26ahr 3238 23 % % NN cord-028721-x6f26ahr 3238 24 of of IN cord-028721-x6f26ahr 3238 25 patients patient NNS cord-028721-x6f26ahr 3238 26 , , , cord-028721-x6f26ahr 3238 27 1354 1354 CD cord-028721-x6f26ahr 3238 28 except except IN cord-028721-x6f26ahr 3238 29 if if IN cord-028721-x6f26ahr 3238 30 early early JJ cord-028721-x6f26ahr 3238 31 treatment treatment NN cord-028721-x6f26ahr 3238 32 is be VBZ cord-028721-x6f26ahr 3238 33 initiated initiate VBN cord-028721-x6f26ahr 3238 34 . . . cord-028721-x6f26ahr 3239 1 1355 1355 CD cord-028721-x6f26ahr 3240 1 The the DT cord-028721-x6f26ahr 3240 2 most most RBS cord-028721-x6f26ahr 3240 3 frequent frequent JJ cord-028721-x6f26ahr 3240 4 fi fi NN cord-028721-x6f26ahr 3240 5 ndings nding NNS cord-028721-x6f26ahr 3240 6 are be VBP cord-028721-x6f26ahr 3240 7 testicular testicular JJ cord-028721-x6f26ahr 3240 8 atrophy atrophy NN cord-028721-x6f26ahr 3240 9 with with IN cord-028721-x6f26ahr 3240 10 diminished diminished JJ cord-028721-x6f26ahr 3240 11 tubular tubular JJ cord-028721-x6f26ahr 3240 12 diameter diameter NN cord-028721-x6f26ahr 3240 13 , , , cord-028721-x6f26ahr 3240 14 tubular tubular JJ cord-028721-x6f26ahr 3240 15 wall wall NN cord-028721-x6f26ahr 3240 16 thickening thickening NN cord-028721-x6f26ahr 3240 17 , , , cord-028721-x6f26ahr 3240 18 a a DT cord-028721-x6f26ahr 3240 19 progressive progressive JJ cord-028721-x6f26ahr 3240 20 decrease decrease NN cord-028721-x6f26ahr 3240 21 in in IN cord-028721-x6f26ahr 3240 22 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3240 23 , , , cord-028721-x6f26ahr 3240 24 and and CC cord-028721-x6f26ahr 3240 25 increased increase VBN cord-028721-x6f26ahr 3240 26 lipofuscin lipofuscin NN cord-028721-x6f26ahr 3240 27 granules granule NNS cord-028721-x6f26ahr 3240 28 in in IN cord-028721-x6f26ahr 3240 29 Leydig Leydig NNP cord-028721-x6f26ahr 3240 30 cells cell NNS cord-028721-x6f26ahr 3240 31 . . . cord-028721-x6f26ahr 3241 1 The the DT cord-028721-x6f26ahr 3241 2 cause cause NN cord-028721-x6f26ahr 3241 3 of of IN cord-028721-x6f26ahr 3241 4 these these DT cord-028721-x6f26ahr 3241 5 testicular testicular JJ cord-028721-x6f26ahr 3241 6 disorders disorder NNS cord-028721-x6f26ahr 3241 7 might may MD cord-028721-x6f26ahr 3241 8 be be VB cord-028721-x6f26ahr 3241 9 preferential preferential JJ cord-028721-x6f26ahr 3241 10 deposition deposition NN cord-028721-x6f26ahr 3241 11 of of IN cord-028721-x6f26ahr 3241 12 iron iron NN cord-028721-x6f26ahr 3241 13 in in IN cord-028721-x6f26ahr 3241 14 gonadotropic gonadotropic NNP cord-028721-x6f26ahr 3241 15 cells cell NNS cord-028721-x6f26ahr 3241 16 . . . cord-028721-x6f26ahr 3242 1 1356 1356 CD cord-028721-x6f26ahr 3243 1 Iron iron NN cord-028721-x6f26ahr 3243 2 deposits deposit NNS cord-028721-x6f26ahr 3243 3 are be VBP cord-028721-x6f26ahr 3243 4 not not RB cord-028721-x6f26ahr 3243 5 observed observe VBN cord-028721-x6f26ahr 3243 6 in in IN cord-028721-x6f26ahr 3243 7 the the DT cord-028721-x6f26ahr 3243 8 testis testis NN cord-028721-x6f26ahr 3243 9 . . . cord-028721-x6f26ahr 3244 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3244 2 decreases decrease VBZ cord-028721-x6f26ahr 3244 3 after after IN cord-028721-x6f26ahr 3244 4 aggressive aggressive JJ cord-028721-x6f26ahr 3244 5 therapy therapy NN cord-028721-x6f26ahr 3244 6 . . . cord-028721-x6f26ahr 3245 1 1357 1357 CD cord-028721-x6f26ahr 3246 1 Polycystic polycystic JJ cord-028721-x6f26ahr 3246 2 renal renal JJ cord-028721-x6f26ahr 3246 3 disease disease NN cord-028721-x6f26ahr 3246 4 in in IN cord-028721-x6f26ahr 3246 5 adults adult NNS cord-028721-x6f26ahr 3246 6 is be VBZ cord-028721-x6f26ahr 3246 7 a a DT cord-028721-x6f26ahr 3246 8 dominant dominant JJ cord-028721-x6f26ahr 3246 9 autosomal autosomal JJ cord-028721-x6f26ahr 3246 10 disorder disorder NN cord-028721-x6f26ahr 3246 11 that that WDT cord-028721-x6f26ahr 3246 12 appears appear VBZ cord-028721-x6f26ahr 3246 13 with with IN cord-028721-x6f26ahr 3246 14 1 1 CD cord-028721-x6f26ahr 3246 15 in in IN cord-028721-x6f26ahr 3246 16 1000 1000 CD cord-028721-x6f26ahr 3246 17 frequency frequency NN cord-028721-x6f26ahr 3246 18 in in IN cord-028721-x6f26ahr 3246 19 the the DT cord-028721-x6f26ahr 3246 20 general general JJ cord-028721-x6f26ahr 3246 21 population population NN cord-028721-x6f26ahr 3246 22 . . . cord-028721-x6f26ahr 3247 1 Patients patient NNS cord-028721-x6f26ahr 3247 2 with with IN cord-028721-x6f26ahr 3247 3 this this DT cord-028721-x6f26ahr 3247 4 disease disease NN cord-028721-x6f26ahr 3247 5 comprise comprise VBP cord-028721-x6f26ahr 3247 6 10 10 CD cord-028721-x6f26ahr 3247 7 % % NN cord-028721-x6f26ahr 3247 8 of of IN cord-028721-x6f26ahr 3247 9 end end NN cord-028721-x6f26ahr 3247 10 - - HYPH cord-028721-x6f26ahr 3247 11 stage stage NN cord-028721-x6f26ahr 3247 12 renal renal JJ cord-028721-x6f26ahr 3247 13 failure failure NN cord-028721-x6f26ahr 3247 14 cases case NNS cord-028721-x6f26ahr 3247 15 . . . cord-028721-x6f26ahr 3248 1 1358 1358 CD cord-028721-x6f26ahr 3248 2 Infertility Infertility NNP cord-028721-x6f26ahr 3248 3 is be VBZ cord-028721-x6f26ahr 3248 4 common common JJ cord-028721-x6f26ahr 3248 5 , , , cord-028721-x6f26ahr 3248 6 even even RB cord-028721-x6f26ahr 3248 7 before before IN cord-028721-x6f26ahr 3248 8 the the DT cord-028721-x6f26ahr 3248 9 beginning beginning NN cord-028721-x6f26ahr 3248 10 of of IN cord-028721-x6f26ahr 3248 11 renal renal JJ cord-028721-x6f26ahr 3248 12 insuffi insuffi NNP cord-028721-x6f26ahr 3248 13 ciency ciency NNP cord-028721-x6f26ahr 3248 14 . . . cord-028721-x6f26ahr 3249 1 Oligoteratozoospermia Oligoteratozoospermia NNP cord-028721-x6f26ahr 3249 2 and and CC cord-028721-x6f26ahr 3249 3 necrospermia necrospermia NNP cord-028721-x6f26ahr 3249 4 are be VBP cord-028721-x6f26ahr 3249 5 frequent frequent JJ cord-028721-x6f26ahr 3249 6 fi fi NN cord-028721-x6f26ahr 3249 7 ndings nding NNS cord-028721-x6f26ahr 3249 8 . . . cord-028721-x6f26ahr 3250 1 1359 1359 CD cord-028721-x6f26ahr 3250 2 , , , cord-028721-x6f26ahr 3250 3 1360 1360 CD cord-028721-x6f26ahr 3250 4 Serum serum NN cord-028721-x6f26ahr 3250 5 levels level NNS cord-028721-x6f26ahr 3250 6 of of IN cord-028721-x6f26ahr 3250 7 FSH fsh NN cord-028721-x6f26ahr 3250 8 , , , cord-028721-x6f26ahr 3250 9 LH LH NNP cord-028721-x6f26ahr 3250 10 , , , cord-028721-x6f26ahr 3250 11 prolactin prolactin NN cord-028721-x6f26ahr 3250 12 , , , cord-028721-x6f26ahr 3250 13 testosterone testosterone NN cord-028721-x6f26ahr 3250 14 , , , cord-028721-x6f26ahr 3250 15 and and CC cord-028721-x6f26ahr 3250 16 estradiol estradiol NN cord-028721-x6f26ahr 3250 17 remain remain VBP cord-028721-x6f26ahr 3250 18 normal normal JJ cord-028721-x6f26ahr 3250 19 for for IN cord-028721-x6f26ahr 3250 20 a a DT cord-028721-x6f26ahr 3250 21 long long JJ cord-028721-x6f26ahr 3250 22 time time NN cord-028721-x6f26ahr 3250 23 before before IN cord-028721-x6f26ahr 3250 24 the the DT cord-028721-x6f26ahr 3250 25 onset onset NN cord-028721-x6f26ahr 3250 26 of of IN cord-028721-x6f26ahr 3250 27 renal renal JJ cord-028721-x6f26ahr 3250 28 insuffi insuffi NNP cord-028721-x6f26ahr 3250 29 ciency ciency NNP cord-028721-x6f26ahr 3250 30 . . . cord-028721-x6f26ahr 3251 1 The the DT cord-028721-x6f26ahr 3251 2 causes cause NNS cord-028721-x6f26ahr 3251 3 of of IN cord-028721-x6f26ahr 3251 4 spermiogram spermiogram NNP cord-028721-x6f26ahr 3251 5 alterations alteration NNS cord-028721-x6f26ahr 3251 6 have have VBP cord-028721-x6f26ahr 3251 7 been be VBN cord-028721-x6f26ahr 3251 8 related relate VBN cord-028721-x6f26ahr 3251 9 to to IN cord-028721-x6f26ahr 3251 10 partial partial JJ cord-028721-x6f26ahr 3251 11 obstruction obstruction NN cord-028721-x6f26ahr 3251 12 of of IN cord-028721-x6f26ahr 3251 13 ejaculatory ejaculatory NN cord-028721-x6f26ahr 3251 14 ducts duct NNS cord-028721-x6f26ahr 3251 15 ( ( -LRB- cord-028721-x6f26ahr 3251 16 based base VBN cord-028721-x6f26ahr 3251 17 on on IN cord-028721-x6f26ahr 3251 18 fi fi NNP cord-028721-x6f26ahr 3251 19 nding nde VBG cord-028721-x6f26ahr 3251 20 cystic cystic JJ cord-028721-x6f26ahr 3251 21 dilations dilation NNS cord-028721-x6f26ahr 3251 22 in in IN cord-028721-x6f26ahr 3251 23 seminal seminal JJ cord-028721-x6f26ahr 3251 24 vesicles vesicle NNS cord-028721-x6f26ahr 3251 25 in in IN cord-028721-x6f26ahr 3251 26 60 60 CD cord-028721-x6f26ahr 3251 27 % % NN cord-028721-x6f26ahr 3251 28 of of IN cord-028721-x6f26ahr 3251 29 patients patient NNS cord-028721-x6f26ahr 3251 30 ) ) -RRB- cord-028721-x6f26ahr 3251 31 or or CC cord-028721-x6f26ahr 3251 32 seminal seminal JJ cord-028721-x6f26ahr 3251 33 vesicle vesicle NN cord-028721-x6f26ahr 3251 34 cyst cyst NN cord-028721-x6f26ahr 3251 35 . . . cord-028721-x6f26ahr 3252 1 1361 1361 CD cord-028721-x6f26ahr 3253 1 The the DT cord-028721-x6f26ahr 3253 2 incidence incidence NN cord-028721-x6f26ahr 3253 3 of of IN cord-028721-x6f26ahr 3253 4 these these DT cord-028721-x6f26ahr 3253 5 two two CD cord-028721-x6f26ahr 3253 6 disorders disorder NNS cord-028721-x6f26ahr 3253 7 in in IN cord-028721-x6f26ahr 3253 8 patients patient NNS cord-028721-x6f26ahr 3253 9 with with IN cord-028721-x6f26ahr 3253 10 polycystic polycystic JJ cord-028721-x6f26ahr 3253 11 renal renal JJ cord-028721-x6f26ahr 3253 12 disease disease NN cord-028721-x6f26ahr 3253 13 is be VBZ cord-028721-x6f26ahr 3253 14 very very RB cord-028721-x6f26ahr 3253 15 high high JJ cord-028721-x6f26ahr 3253 16 compared compare VBN cord-028721-x6f26ahr 3253 17 to to IN cord-028721-x6f26ahr 3253 18 andrological andrological JJ cord-028721-x6f26ahr 3253 19 patients patient NNS cord-028721-x6f26ahr 3253 20 without without IN cord-028721-x6f26ahr 3253 21 this this DT cord-028721-x6f26ahr 3253 22 disease disease NN cord-028721-x6f26ahr 3253 23 ( ( -LRB- cord-028721-x6f26ahr 3253 24 5.2 5.2 CD cord-028721-x6f26ahr 3253 25 % % NN cord-028721-x6f26ahr 3253 26 ) ) -RRB- cord-028721-x6f26ahr 3253 27 . . . cord-028721-x6f26ahr 3254 1 1362 1362 CD cord-028721-x6f26ahr 3254 2 Chronic Chronic NNP cord-028721-x6f26ahr 3254 3 renal renal JJ cord-028721-x6f26ahr 3254 4 insuffi insuffi NN cord-028721-x6f26ahr 3254 5 ciency ciency NN cord-028721-x6f26ahr 3254 6 is be VBZ cord-028721-x6f26ahr 3254 7 associated associate VBN cord-028721-x6f26ahr 3254 8 with with IN cord-028721-x6f26ahr 3254 9 disturbed disturbed JJ cord-028721-x6f26ahr 3254 10 endocrine endocrine JJ cord-028721-x6f26ahr 3254 11 function function NN cord-028721-x6f26ahr 3254 12 in in IN cord-028721-x6f26ahr 3254 13 the the DT cord-028721-x6f26ahr 3254 14 pituitary pituitary NN cord-028721-x6f26ahr 3254 15 , , , cord-028721-x6f26ahr 3254 16 thyroid thyroid NN cord-028721-x6f26ahr 3254 17 , , , cord-028721-x6f26ahr 3254 18 parathyroids parathyroid NNS cord-028721-x6f26ahr 3254 19 , , , cord-028721-x6f26ahr 3254 20 and and CC cord-028721-x6f26ahr 3254 21 testes testis NNS cord-028721-x6f26ahr 3254 22 . . . cord-028721-x6f26ahr 3255 1 The the DT cord-028721-x6f26ahr 3255 2 associated associated JJ cord-028721-x6f26ahr 3255 3 sexual sexual JJ cord-028721-x6f26ahr 3255 4 dysfunction dysfunction NN cord-028721-x6f26ahr 3255 5 consists consist VBZ cord-028721-x6f26ahr 3255 6 of of IN cord-028721-x6f26ahr 3255 7 erectile erectile NN cord-028721-x6f26ahr 3255 8 impotence impotence NN cord-028721-x6f26ahr 3255 9 , , , cord-028721-x6f26ahr 3255 10 diminution diminution NN cord-028721-x6f26ahr 3255 11 of of IN cord-028721-x6f26ahr 3255 12 libido libido NN cord-028721-x6f26ahr 3255 13 and and CC cord-028721-x6f26ahr 3255 14 semen semen NN cord-028721-x6f26ahr 3255 15 volume volume NN cord-028721-x6f26ahr 3255 16 , , , cord-028721-x6f26ahr 3255 17 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3255 18 or or CC cord-028721-x6f26ahr 3255 19 azoospermia azoospermia NN cord-028721-x6f26ahr 3255 20 , , , cord-028721-x6f26ahr 3255 21 and and CC cord-028721-x6f26ahr 3255 22 infertility infertility NN cord-028721-x6f26ahr 3255 23 . . . cord-028721-x6f26ahr 3256 1 In in IN cord-028721-x6f26ahr 3256 2 children child NNS cord-028721-x6f26ahr 3256 3 , , , cord-028721-x6f26ahr 3256 4 skeletal skeletal JJ cord-028721-x6f26ahr 3256 5 development development NN cord-028721-x6f26ahr 3256 6 and and CC cord-028721-x6f26ahr 3256 7 puberty puberty NN cord-028721-x6f26ahr 3256 8 are be VBP cord-028721-x6f26ahr 3256 9 delayed delay VBN cord-028721-x6f26ahr 3256 10 . . . cord-028721-x6f26ahr 3257 1 1363 1363 CD cord-028721-x6f26ahr 3257 2 Hormonal hormonal JJ cord-028721-x6f26ahr 3257 3 studies study NNS cord-028721-x6f26ahr 3257 4 reveal reveal VBP cord-028721-x6f26ahr 3257 5 elevated elevated JJ cord-028721-x6f26ahr 3257 6 levels level NNS cord-028721-x6f26ahr 3257 7 of of IN cord-028721-x6f26ahr 3257 8 FSH fsh NN cord-028721-x6f26ahr 3257 9 , , , cord-028721-x6f26ahr 3257 10 LH LH NNP cord-028721-x6f26ahr 3257 11 , , , cord-028721-x6f26ahr 3257 12 and and CC cord-028721-x6f26ahr 3257 13 prolactin prolactin NN cord-028721-x6f26ahr 3257 14 , , , cord-028721-x6f26ahr 3257 15 but but CC cord-028721-x6f26ahr 3257 16 testosterone testosterone NN cord-028721-x6f26ahr 3257 17 levels level NNS cord-028721-x6f26ahr 3257 18 are be VBP cord-028721-x6f26ahr 3257 19 low low JJ cord-028721-x6f26ahr 3257 20 . . . cord-028721-x6f26ahr 3258 1 1364 1364 CD cord-028721-x6f26ahr 3258 2 Testicular Testicular NNP cord-028721-x6f26ahr 3258 3 biopsy biopsy NN cord-028721-x6f26ahr 3258 4 shows show VBZ cord-028721-x6f26ahr 3258 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 3258 6 tubules tubule NNS cord-028721-x6f26ahr 3258 7 with with IN cord-028721-x6f26ahr 3258 8 reduced reduced JJ cord-028721-x6f26ahr 3258 9 diameters diameter NNS cord-028721-x6f26ahr 3258 10 and and CC cord-028721-x6f26ahr 3258 11 reduced reduce VBN cord-028721-x6f26ahr 3258 12 or or CC cord-028721-x6f26ahr 3258 13 absent absent JJ cord-028721-x6f26ahr 3258 14 germ germ NN cord-028721-x6f26ahr 3258 15 cells cell NNS cord-028721-x6f26ahr 3258 16 ( ( -LRB- cord-028721-x6f26ahr 3258 17 Fig Fig NNP cord-028721-x6f26ahr 3258 18 . . . cord-028721-x6f26ahr 3258 19 12 12 CD cord-028721-x6f26ahr 3258 20 - - SYM cord-028721-x6f26ahr 3258 21 148 148 CD cord-028721-x6f26ahr 3258 22 ) ) -RRB- cord-028721-x6f26ahr 3258 23 . . . cord-028721-x6f26ahr 3259 1 1365 1365 CD cord-028721-x6f26ahr 3259 2 , , , cord-028721-x6f26ahr 3259 3 1366 1366 CD cord-028721-x6f26ahr 3260 1 The the DT cord-028721-x6f26ahr 3260 2 interstitium interstitium NN cord-028721-x6f26ahr 3260 3 contains contain VBZ cord-028721-x6f26ahr 3260 4 a a DT cord-028721-x6f26ahr 3260 5 normal normal JJ cord-028721-x6f26ahr 3260 6 number number NN cord-028721-x6f26ahr 3260 7 of of IN cord-028721-x6f26ahr 3260 8 Leydig Leydig NNP cord-028721-x6f26ahr 3260 9 cells cell NNS cord-028721-x6f26ahr 3260 10 and and CC cord-028721-x6f26ahr 3260 11 increased increase VBN cord-028721-x6f26ahr 3260 12 numbers number NNS cord-028721-x6f26ahr 3260 13 of of IN cord-028721-x6f26ahr 3260 14 macrophages macrophage NNS cord-028721-x6f26ahr 3260 15 . . . cord-028721-x6f26ahr 3261 1 Additionally additionally RB cord-028721-x6f26ahr 3261 2 , , , cord-028721-x6f26ahr 3261 3 patients patient NNS cord-028721-x6f26ahr 3261 4 with with IN cord-028721-x6f26ahr 3261 5 chronic chronic JJ cord-028721-x6f26ahr 3261 6 renal renal JJ cord-028721-x6f26ahr 3261 7 insuffi insuffi NN cord-028721-x6f26ahr 3261 8 ciency ciency NN cord-028721-x6f26ahr 3261 9 due due IN cord-028721-x6f26ahr 3261 10 to to IN cord-028721-x6f26ahr 3261 11 glomerulonephritis glomerulonephritis NN cord-028721-x6f26ahr 3261 12 have have VBP cord-028721-x6f26ahr 3261 13 thickening thickening NN cord-028721-x6f26ahr 3261 14 of of IN cord-028721-x6f26ahr 3261 15 the the DT cord-028721-x6f26ahr 3261 16 tubular tubular JJ cord-028721-x6f26ahr 3261 17 lamina lamina NN cord-028721-x6f26ahr 3261 18 propria propria NN cord-028721-x6f26ahr 3261 19 and and CC cord-028721-x6f26ahr 3261 20 decreased decrease VBD cord-028721-x6f26ahr 3261 21 number number NN cord-028721-x6f26ahr 3261 22 of of IN cord-028721-x6f26ahr 3261 23 Leydig Leydig NNP cord-028721-x6f26ahr 3261 24 cells cell NNS cord-028721-x6f26ahr 3261 25 . . . cord-028721-x6f26ahr 3262 1 Patients patient NNS cord-028721-x6f26ahr 3262 2 with with IN cord-028721-x6f26ahr 3262 3 end end NN cord-028721-x6f26ahr 3262 4 - - HYPH cord-028721-x6f26ahr 3262 5 stage stage NN cord-028721-x6f26ahr 3262 6 renal renal JJ cord-028721-x6f26ahr 3262 7 disease disease NN cord-028721-x6f26ahr 3262 8 who who WP cord-028721-x6f26ahr 3262 9 undergo undergo VBP cord-028721-x6f26ahr 3262 10 dialysis dialysis NN cord-028721-x6f26ahr 3262 11 show show VBP cord-028721-x6f26ahr 3262 12 calcifi calcifi NN cord-028721-x6f26ahr 3262 13 cations cation NNS cord-028721-x6f26ahr 3262 14 in in IN cord-028721-x6f26ahr 3262 15 several several JJ cord-028721-x6f26ahr 3262 16 organs organ NNS cord-028721-x6f26ahr 3262 17 and and CC cord-028721-x6f26ahr 3262 18 tissues tissue NNS cord-028721-x6f26ahr 3262 19 , , , cord-028721-x6f26ahr 3262 20 including include VBG cord-028721-x6f26ahr 3262 21 the the DT cord-028721-x6f26ahr 3262 22 male male JJ cord-028721-x6f26ahr 3262 23 genital genital NN cord-028721-x6f26ahr 3262 24 system system NN cord-028721-x6f26ahr 3262 25 ( ( -LRB- cord-028721-x6f26ahr 3262 26 epididymidis epididymidis NNP cord-028721-x6f26ahr 3262 27 , , , cord-028721-x6f26ahr 3262 28 tunica tunica NNP cord-028721-x6f26ahr 3262 29 albuginea albuginea NNP cord-028721-x6f26ahr 3262 30 , , , cord-028721-x6f26ahr 3262 31 and and CC cord-028721-x6f26ahr 3262 32 cavernous cavernous JJ cord-028721-x6f26ahr 3262 33 tissue tissue NN cord-028721-x6f26ahr 3262 34 ) ) -RRB- cord-028721-x6f26ahr 3262 35 in in IN cord-028721-x6f26ahr 3262 36 87 87 CD cord-028721-x6f26ahr 3262 37 % % NN cord-028721-x6f26ahr 3262 38 of of IN cord-028721-x6f26ahr 3262 39 cases case NNS cord-028721-x6f26ahr 3262 40 , , , cord-028721-x6f26ahr 3262 41 and and CC cord-028721-x6f26ahr 3262 42 , , , cord-028721-x6f26ahr 3262 43 in in IN cord-028721-x6f26ahr 3262 44 isolated isolated JJ cord-028721-x6f26ahr 3262 45 cases case NNS cord-028721-x6f26ahr 3262 46 , , , cord-028721-x6f26ahr 3262 47 calcifi calcifi NNP cord-028721-x6f26ahr 3262 48 cation cation NN cord-028721-x6f26ahr 3262 49 of of IN cord-028721-x6f26ahr 3262 50 the the DT cord-028721-x6f26ahr 3262 51 testicular testicular JJ cord-028721-x6f26ahr 3262 52 parenchyma parenchyma NN cord-028721-x6f26ahr 3262 53 and and CC cord-028721-x6f26ahr 3262 54 microlithiasis microlithiasis NN cord-028721-x6f26ahr 3262 55 . . . cord-028721-x6f26ahr 3263 1 1367 1367 CD cord-028721-x6f26ahr 3263 2 Elevated elevated JJ cord-028721-x6f26ahr 3263 3 serum serum NN cord-028721-x6f26ahr 3263 4 levels level NNS cord-028721-x6f26ahr 3263 5 of of IN cord-028721-x6f26ahr 3263 6 phosphorus phosphorus NN cord-028721-x6f26ahr 3263 7 , , , cord-028721-x6f26ahr 3263 8 increased increase VBN cord-028721-x6f26ahr 3263 9 calciumphosphorus calciumphosphorus JJ cord-028721-x6f26ahr 3263 10 product product NN cord-028721-x6f26ahr 3263 11 , , , cord-028721-x6f26ahr 3263 12 severe severe JJ cord-028721-x6f26ahr 3263 13 hyperparathyroidism hyperparathyroidism NN cord-028721-x6f26ahr 3263 14 secondary secondary JJ cord-028721-x6f26ahr 3263 15 to to IN cord-028721-x6f26ahr 3263 16 other other JJ cord-028721-x6f26ahr 3263 17 disorders disorder NNS cord-028721-x6f26ahr 3263 18 , , , cord-028721-x6f26ahr 3263 19 older old JJR cord-028721-x6f26ahr 3263 20 age age NN cord-028721-x6f26ahr 3263 21 , , , cord-028721-x6f26ahr 3263 22 and and CC cord-028721-x6f26ahr 3263 23 prolonged prolong VBN cord-028721-x6f26ahr 3263 24 time time NN cord-028721-x6f26ahr 3263 25 on on IN cord-028721-x6f26ahr 3263 26 dialysis dialysis NN cord-028721-x6f26ahr 3263 27 contribute contribute VBP cord-028721-x6f26ahr 3263 28 to to IN cord-028721-x6f26ahr 3263 29 this this DT cord-028721-x6f26ahr 3263 30 disorder disorder NN cord-028721-x6f26ahr 3263 31 . . . cord-028721-x6f26ahr 3264 1 Uremic uremic JJ cord-028721-x6f26ahr 3264 2 calcifi calcifi NNP cord-028721-x6f26ahr 3264 3 cation cation NN cord-028721-x6f26ahr 3264 4 is be VBZ cord-028721-x6f26ahr 3264 5 a a DT cord-028721-x6f26ahr 3264 6 cell cell NN cord-028721-x6f26ahr 3264 7 - - HYPH cord-028721-x6f26ahr 3264 8 mediated mediate VBN cord-028721-x6f26ahr 3264 9 process process NN cord-028721-x6f26ahr 3264 10 in in IN cord-028721-x6f26ahr 3264 11 which which WDT cord-028721-x6f26ahr 3264 12 elevated elevated JJ cord-028721-x6f26ahr 3264 13 levels level NNS cord-028721-x6f26ahr 3264 14 of of IN cord-028721-x6f26ahr 3264 15 TGF TGF NNP cord-028721-x6f26ahr 3264 16 , , , cord-028721-x6f26ahr 3264 17 vitamin vitamin NN cord-028721-x6f26ahr 3264 18 K k NN cord-028721-x6f26ahr 3264 19 - - HYPH cord-028721-x6f26ahr 3264 20 dependent dependent JJ cord-028721-x6f26ahr 3264 21 proteins protein NNS cord-028721-x6f26ahr 3264 22 such such JJ cord-028721-x6f26ahr 3264 23 as as IN cord-028721-x6f26ahr 3264 24 osteocalcin osteocalcin NN cord-028721-x6f26ahr 3264 25 and and CC cord-028721-x6f26ahr 3264 26 atherocalcin atherocalcin NNS cord-028721-x6f26ahr 3264 27 , , , cord-028721-x6f26ahr 3264 28 and and CC cord-028721-x6f26ahr 3264 29 defects defect NNS cord-028721-x6f26ahr 3264 30 in in IN cord-028721-x6f26ahr 3264 31 calcium calcium NN cord-028721-x6f26ahr 3264 32 - - HYPH cord-028721-x6f26ahr 3264 33 regulatory regulatory JJ cord-028721-x6f26ahr 3264 34 proteins protein NNS cord-028721-x6f26ahr 3264 35 such such JJ cord-028721-x6f26ahr 3264 36 as as IN cord-028721-x6f26ahr 3264 37 fetuin fetuin NNP cord-028721-x6f26ahr 3264 38 are be VBP cord-028721-x6f26ahr 3264 39 implicated implicate VBN cord-028721-x6f26ahr 3264 40 . . . cord-028721-x6f26ahr 3265 1 1368 1368 CD cord-028721-x6f26ahr 3266 1 When when WRB cord-028721-x6f26ahr 3266 2 these these DT cord-028721-x6f26ahr 3266 3 patients patient NNS cord-028721-x6f26ahr 3266 4 are be VBP cord-028721-x6f26ahr 3266 5 dialyzed dialyze VBN cord-028721-x6f26ahr 3266 6 , , , cord-028721-x6f26ahr 3266 7 accumulations accumulation NNS cord-028721-x6f26ahr 3266 8 of of IN cord-028721-x6f26ahr 3266 9 urate urate NN cord-028721-x6f26ahr 3266 10 and and CC cord-028721-x6f26ahr 3266 11 oxalate oxalate NN cord-028721-x6f26ahr 3266 12 crystals crystal NNS cord-028721-x6f26ahr 3266 13 are be VBP cord-028721-x6f26ahr 3266 14 deposited deposit VBN cord-028721-x6f26ahr 3266 15 in in IN cord-028721-x6f26ahr 3266 16 the the DT cord-028721-x6f26ahr 3266 17 rete rete NN cord-028721-x6f26ahr 3266 18 testes testis NNS cord-028721-x6f26ahr 3266 19 and and CC cord-028721-x6f26ahr 3266 20 ductuli ductuli NNP cord-028721-x6f26ahr 3266 21 efferentes efferentes NNP cord-028721-x6f26ahr 3266 22 . . . cord-028721-x6f26ahr 3267 1 These these DT cord-028721-x6f26ahr 3267 2 crystals crystal NNS cord-028721-x6f26ahr 3267 3 are be VBP cord-028721-x6f26ahr 3267 4 deposited deposit VBN cord-028721-x6f26ahr 3267 5 beneath beneath IN cord-028721-x6f26ahr 3267 6 the the DT cord-028721-x6f26ahr 3267 7 epithelium epithelium NN cord-028721-x6f26ahr 3267 8 and and CC cord-028721-x6f26ahr 3267 9 often often RB cord-028721-x6f26ahr 3267 10 sloughed slough VBN cord-028721-x6f26ahr 3267 11 into into IN cord-028721-x6f26ahr 3267 12 the the DT cord-028721-x6f26ahr 3267 13 lumen lumen NN cord-028721-x6f26ahr 3267 14 . . . cord-028721-x6f26ahr 3268 1 Reactive reactive JJ cord-028721-x6f26ahr 3268 2 changes change NNS cord-028721-x6f26ahr 3268 3 in in IN cord-028721-x6f26ahr 3268 4 the the DT cord-028721-x6f26ahr 3268 5 rete rete NN cord-028721-x6f26ahr 3268 6 testis testis NN cord-028721-x6f26ahr 3268 7 , , , cord-028721-x6f26ahr 3268 8 including include VBG cord-028721-x6f26ahr 3268 9 cystic cystic JJ cord-028721-x6f26ahr 3268 10 transformation transformation NN cord-028721-x6f26ahr 3268 11 , , , cord-028721-x6f26ahr 3268 12 are be VBP cord-028721-x6f26ahr 3268 13 frequent frequent JJ cord-028721-x6f26ahr 3268 14 ( ( -LRB- cord-028721-x6f26ahr 3268 15 see see VB cord-028721-x6f26ahr 3268 16 Disorders disorder NNS cord-028721-x6f26ahr 3268 17 of of IN cord-028721-x6f26ahr 3268 18 the the DT cord-028721-x6f26ahr 3268 19 rete rete NN cord-028721-x6f26ahr 3268 20 testis testis NN cord-028721-x6f26ahr 3268 21 ) ) -RRB- cord-028721-x6f26ahr 3268 22 . . . cord-028721-x6f26ahr 3269 1 1369 1369 CD cord-028721-x6f26ahr 3270 1 The the DT cord-028721-x6f26ahr 3270 2 cause cause NN cord-028721-x6f26ahr 3270 3 of of IN cord-028721-x6f26ahr 3270 4 gonadal gonadal JJ cord-028721-x6f26ahr 3270 5 dysfunction dysfunction NN cord-028721-x6f26ahr 3270 6 is be VBZ cord-028721-x6f26ahr 3270 7 unclear unclear JJ cord-028721-x6f26ahr 3270 8 and and CC cord-028721-x6f26ahr 3270 9 probably probably RB cord-028721-x6f26ahr 3270 10 involves involve VBZ cord-028721-x6f26ahr 3270 11 several several JJ cord-028721-x6f26ahr 3270 12 factors factor NNS cord-028721-x6f26ahr 3270 13 , , , cord-028721-x6f26ahr 3270 14 including include VBG cord-028721-x6f26ahr 3270 15 impaired impair VBN cord-028721-x6f26ahr 3270 16 testicular testicular JJ cord-028721-x6f26ahr 3270 17 steroidogenesis steroidogenesis NN cord-028721-x6f26ahr 3270 18 , , , cord-028721-x6f26ahr 3270 19 1370 1370 CD cord-028721-x6f26ahr 3270 20 reduced reduced JJ cord-028721-x6f26ahr 3270 21 clearance clearance NN cord-028721-x6f26ahr 3270 22 of of IN cord-028721-x6f26ahr 3270 23 pituitary pituitary JJ cord-028721-x6f26ahr 3270 24 hormones hormone NNS cord-028721-x6f26ahr 3270 25 , , , cord-028721-x6f26ahr 3270 26 1371 1371 CD cord-028721-x6f26ahr 3270 27 and and CC cord-028721-x6f26ahr 3270 28 secretory secretory JJ cord-028721-x6f26ahr 3270 29 defects defect NNS cord-028721-x6f26ahr 3270 30 of of IN cord-028721-x6f26ahr 3270 31 the the DT cord-028721-x6f26ahr 3270 32 pituitary pituitary NN cord-028721-x6f26ahr 3270 33 and and CC cord-028721-x6f26ahr 3270 34 hypothalamus hypothalamus NN cord-028721-x6f26ahr 3270 35 . . . cord-028721-x6f26ahr 3271 1 1372 1372 CD cord-028721-x6f26ahr 3271 2 Dialysis Dialysis NNP cord-028721-x6f26ahr 3271 3 does do VBZ cord-028721-x6f26ahr 3271 4 not not RB cord-028721-x6f26ahr 3271 5 improve improve VB cord-028721-x6f26ahr 3271 6 testicular testicular JJ cord-028721-x6f26ahr 3271 7 function function NN cord-028721-x6f26ahr 3271 8 . . . cord-028721-x6f26ahr 3272 1 The the DT cord-028721-x6f26ahr 3272 2 response response NN cord-028721-x6f26ahr 3272 3 to to IN cord-028721-x6f26ahr 3272 4 renal renal JJ cord-028721-x6f26ahr 3272 5 transplantation transplantation NN cord-028721-x6f26ahr 3272 6 is be VBZ cord-028721-x6f26ahr 3272 7 not not RB cord-028721-x6f26ahr 3272 8 immediate immediate JJ cord-028721-x6f26ahr 3272 9 and and CC cord-028721-x6f26ahr 3272 10 is be VBZ cord-028721-x6f26ahr 3272 11 related relate VBN cord-028721-x6f26ahr 3272 12 to to IN cord-028721-x6f26ahr 3272 13 the the DT cord-028721-x6f26ahr 3272 14 glomerular glomerular JJ cord-028721-x6f26ahr 3272 15 fi fi NN cord-028721-x6f26ahr 3272 16 ltration ltration NN cord-028721-x6f26ahr 3272 17 rate rate NN cord-028721-x6f26ahr 3272 18 . . . cord-028721-x6f26ahr 3273 1 Patients patient NNS cord-028721-x6f26ahr 3273 2 with with IN cord-028721-x6f26ahr 3273 3 rates rate NNS cord-028721-x6f26ahr 3273 4 lower low JJR cord-028721-x6f26ahr 3273 5 than than IN cord-028721-x6f26ahr 3273 6 50 50 CD cord-028721-x6f26ahr 3273 7 mL ml NN cord-028721-x6f26ahr 3273 8 / / SYM cord-028721-x6f26ahr 3273 9 min min NN cord-028721-x6f26ahr 3273 10 develop develop VBP cord-028721-x6f26ahr 3273 11 atrophy atrophy NN cord-028721-x6f26ahr 3273 12 of of IN cord-028721-x6f26ahr 3273 13 the the DT cord-028721-x6f26ahr 3273 14 seminiferous seminiferous JJ cord-028721-x6f26ahr 3273 15 tubular tubular JJ cord-028721-x6f26ahr 3273 16 cells cell NNS cord-028721-x6f26ahr 3273 17 . . . cord-028721-x6f26ahr 3274 1 1370 1370 CD cord-028721-x6f26ahr 3274 2 _SP cord-028721-x6f26ahr 3275 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3275 2 is be VBZ cord-028721-x6f26ahr 3275 3 a a DT cord-028721-x6f26ahr 3275 4 frequent frequent JJ cord-028721-x6f26ahr 3275 5 fi fi NN cord-028721-x6f26ahr 3275 6 nding nding NN cord-028721-x6f26ahr 3275 7 in in IN cord-028721-x6f26ahr 3275 8 men man NNS cord-028721-x6f26ahr 3275 9 with with IN cord-028721-x6f26ahr 3275 10 celiac celiac JJ cord-028721-x6f26ahr 3275 11 disease disease NN cord-028721-x6f26ahr 3275 12 , , , cord-028721-x6f26ahr 3275 13 and and CC cord-028721-x6f26ahr 3275 14 results result NNS cord-028721-x6f26ahr 3275 15 in in IN cord-028721-x6f26ahr 3275 16 clinical clinical JJ cord-028721-x6f26ahr 3275 17 symptoms symptom NNS cord-028721-x6f26ahr 3275 18 in in IN cord-028721-x6f26ahr 3275 19 5 5 CD cord-028721-x6f26ahr 3275 20 - - SYM cord-028721-x6f26ahr 3275 21 10 10 CD cord-028721-x6f26ahr 3275 22 % % NN cord-028721-x6f26ahr 3275 23 of of IN cord-028721-x6f26ahr 3275 24 untreated untreated JJ cord-028721-x6f26ahr 3275 25 patients patient NNS cord-028721-x6f26ahr 3275 26 . . . cord-028721-x6f26ahr 3276 1 Celiac celiac JJ cord-028721-x6f26ahr 3276 2 disease disease NN cord-028721-x6f26ahr 3276 3 causes cause VBZ cord-028721-x6f26ahr 3276 4 infertility infertility NN cord-028721-x6f26ahr 3276 5 in in IN cord-028721-x6f26ahr 3276 6 some some DT cord-028721-x6f26ahr 3276 7 cases case NNS cord-028721-x6f26ahr 3276 8 . . . cord-028721-x6f26ahr 3277 1 Spermiograms spermiogram NNS cord-028721-x6f26ahr 3277 2 show show VBP cord-028721-x6f26ahr 3277 3 reduced reduce VBN cord-028721-x6f26ahr 3277 4 motility motility NN cord-028721-x6f26ahr 3277 5 and and CC cord-028721-x6f26ahr 3277 6 numerous numerous JJ cord-028721-x6f26ahr 3277 7 morphologic morphologic JJ cord-028721-x6f26ahr 3277 8 anomalies anomaly NNS cord-028721-x6f26ahr 3277 9 in in IN cord-028721-x6f26ahr 3277 10 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3277 11 . . . cord-028721-x6f26ahr 3278 1 Hormonal hormonal JJ cord-028721-x6f26ahr 3278 2 studies study NNS cord-028721-x6f26ahr 3278 3 show show VBP cord-028721-x6f26ahr 3278 4 elevated elevated JJ cord-028721-x6f26ahr 3278 5 serum serum NN cord-028721-x6f26ahr 3278 6 FSH fsh NN cord-028721-x6f26ahr 3278 7 levels level NNS cord-028721-x6f26ahr 3278 8 in in IN cord-028721-x6f26ahr 3278 9 more more JJR cord-028721-x6f26ahr 3278 10 than than IN cord-028721-x6f26ahr 3278 11 25 25 CD cord-028721-x6f26ahr 3278 12 % % NN cord-028721-x6f26ahr 3278 13 of of IN cord-028721-x6f26ahr 3278 14 men man NNS cord-028721-x6f26ahr 3278 15 with with IN cord-028721-x6f26ahr 3278 16 celiac celiac JJ cord-028721-x6f26ahr 3278 17 disease disease NN cord-028721-x6f26ahr 3278 18 . . . cord-028721-x6f26ahr 3279 1 LH LH NNP cord-028721-x6f26ahr 3279 2 also also RB cord-028721-x6f26ahr 3279 3 is be VBZ cord-028721-x6f26ahr 3279 4 increased increase VBN cord-028721-x6f26ahr 3279 5 in in IN cord-028721-x6f26ahr 3279 6 more more JJR cord-028721-x6f26ahr 3279 7 than than IN cord-028721-x6f26ahr 3279 8 50 50 CD cord-028721-x6f26ahr 3279 9 % % NN cord-028721-x6f26ahr 3279 10 of of IN cord-028721-x6f26ahr 3279 11 these these DT cord-028721-x6f26ahr 3279 12 men man NNS cord-028721-x6f26ahr 3279 13 . . . cord-028721-x6f26ahr 3280 1 The the DT cord-028721-x6f26ahr 3280 2 response response NN cord-028721-x6f26ahr 3280 3 of of IN cord-028721-x6f26ahr 3280 4 FSH FSH NNP cord-028721-x6f26ahr 3280 5 and and CC cord-028721-x6f26ahr 3280 6 LH LH NNP cord-028721-x6f26ahr 3280 7 to to IN cord-028721-x6f26ahr 3280 8 GnRH gnrh JJ cord-028721-x6f26ahr 3280 9 stimulation stimulation NN cord-028721-x6f26ahr 3280 10 is be VBZ cord-028721-x6f26ahr 3280 11 excessive excessive JJ cord-028721-x6f26ahr 3280 12 . . . cord-028721-x6f26ahr 3281 1 The the DT cord-028721-x6f26ahr 3281 2 cause cause NN cord-028721-x6f26ahr 3281 3 of of IN cord-028721-x6f26ahr 3281 4 this this DT cord-028721-x6f26ahr 3281 5 pituitary pituitary JJ cord-028721-x6f26ahr 3281 6 derangement derangement NN cord-028721-x6f26ahr 3281 7 is be VBZ cord-028721-x6f26ahr 3281 8 unknown unknown JJ cord-028721-x6f26ahr 3281 9 . . . cord-028721-x6f26ahr 3282 1 Sperm sperm NN cord-028721-x6f26ahr 3282 2 anomalies anomaly NNS cord-028721-x6f26ahr 3282 3 are be VBP cord-028721-x6f26ahr 3282 4 not not RB cord-028721-x6f26ahr 3282 5 always always RB cord-028721-x6f26ahr 3282 6 corrected correct VBN cord-028721-x6f26ahr 3282 7 by by IN cord-028721-x6f26ahr 3282 8 a a DT cord-028721-x6f26ahr 3282 9 gluten gluten NN cord-028721-x6f26ahr 3282 10 - - HYPH cord-028721-x6f26ahr 3282 11 free free JJ cord-028721-x6f26ahr 3282 12 diet diet NN cord-028721-x6f26ahr 3282 13 . . . cord-028721-x6f26ahr 3283 1 Studies study NNS cord-028721-x6f26ahr 3283 2 in in IN cord-028721-x6f26ahr 3283 3 patients patient NNS cord-028721-x6f26ahr 3283 4 with with IN cord-028721-x6f26ahr 3283 5 ulcerative ulcerative JJ cord-028721-x6f26ahr 3283 6 colitis colitis NN cord-028721-x6f26ahr 3283 7 and and CC cord-028721-x6f26ahr 3283 8 regional regional JJ cord-028721-x6f26ahr 3283 9 enteritis enteritis NN cord-028721-x6f26ahr 3283 10 reveal reveal VBP cord-028721-x6f26ahr 3283 11 a a DT cord-028721-x6f26ahr 3283 12 low low JJ cord-028721-x6f26ahr 3283 13 sperm sperm NN cord-028721-x6f26ahr 3283 14 count count NN cord-028721-x6f26ahr 3283 15 , , , cord-028721-x6f26ahr 3283 16 impaired impaired JJ cord-028721-x6f26ahr 3283 17 motility motility NN cord-028721-x6f26ahr 3283 18 , , , cord-028721-x6f26ahr 3283 19 and and CC cord-028721-x6f26ahr 3283 20 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 3283 21 alterations alteration NNS cord-028721-x6f26ahr 3283 22 , , , cord-028721-x6f26ahr 3283 23 including include VBG cord-028721-x6f26ahr 3283 24 nuclear nuclear JJ cord-028721-x6f26ahr 3283 25 pleomorphism pleomorphism NN cord-028721-x6f26ahr 3283 26 and and CC cord-028721-x6f26ahr 3283 27 chromatin chromatin NN cord-028721-x6f26ahr 3283 28 malcondensation malcondensation NN cord-028721-x6f26ahr 3283 29 and and CC cord-028721-x6f26ahr 3283 30 decondensation decondensation NN cord-028721-x6f26ahr 3283 31 . . . cord-028721-x6f26ahr 3284 1 Zinc zinc NN cord-028721-x6f26ahr 3284 2 defi defi NN cord-028721-x6f26ahr 3284 3 cit cit NNP cord-028721-x6f26ahr 3284 4 may may MD cord-028721-x6f26ahr 3284 5 be be VB cord-028721-x6f26ahr 3284 6 responsible responsible JJ cord-028721-x6f26ahr 3284 7 for for IN cord-028721-x6f26ahr 3284 8 these these DT cord-028721-x6f26ahr 3284 9 alterations alteration NNS cord-028721-x6f26ahr 3284 10 in in IN cord-028721-x6f26ahr 3284 11 Crohn Crohn NNP cord-028721-x6f26ahr 3284 12 's 's POS cord-028721-x6f26ahr 3284 13 disease disease NN cord-028721-x6f26ahr 3284 14 . . . cord-028721-x6f26ahr 3285 1 1373 1373 CD cord-028721-x6f26ahr 3286 1 The the DT cord-028721-x6f26ahr 3286 2 alterations alteration NNS cord-028721-x6f26ahr 3286 3 apparently apparently RB cord-028721-x6f26ahr 3286 4 are be VBP cord-028721-x6f26ahr 3286 5 related relate VBN cord-028721-x6f26ahr 3286 6 to to IN cord-028721-x6f26ahr 3286 7 the the DT cord-028721-x6f26ahr 3286 8 extent extent NN cord-028721-x6f26ahr 3286 9 of of IN cord-028721-x6f26ahr 3286 10 the the DT cord-028721-x6f26ahr 3286 11 intestinal intestinal JJ cord-028721-x6f26ahr 3286 12 lesions lesion NNS cord-028721-x6f26ahr 3286 13 and and CC cord-028721-x6f26ahr 3286 14 the the DT cord-028721-x6f26ahr 3286 15 severity severity NN cord-028721-x6f26ahr 3286 16 of of IN cord-028721-x6f26ahr 3286 17 symptoms symptom NNS cord-028721-x6f26ahr 3286 18 . . . cord-028721-x6f26ahr 3287 1 1374 1374 CD cord-028721-x6f26ahr 3287 2 Patients patient NNS cord-028721-x6f26ahr 3287 3 with with IN cord-028721-x6f26ahr 3287 4 ulcerative ulcerative JJ cord-028721-x6f26ahr 3287 5 colitis colitis NN cord-028721-x6f26ahr 3287 6 treated treat VBN cord-028721-x6f26ahr 3287 7 with with IN cord-028721-x6f26ahr 3287 8 salazopyrine salazopyrine NNP cord-028721-x6f26ahr 3287 9 , , , cord-028721-x6f26ahr 3287 10 1375 1375 CD cord-028721-x6f26ahr 3287 11 mesalazine mesalazine NN cord-028721-x6f26ahr 3287 12 1376 1376 CD cord-028721-x6f26ahr 3287 13 or or CC cord-028721-x6f26ahr 3287 14 fasalazine fasalazine NN cord-028721-x6f26ahr 3287 15 1377 1377 CD cord-028721-x6f26ahr 3287 16 present present NN cord-028721-x6f26ahr 3287 17 with with IN cord-028721-x6f26ahr 3287 18 signifi signifi NNP cord-028721-x6f26ahr 3288 1 ca can MD cord-028721-x6f26ahr 3288 2 nt not RB cord-028721-x6f26ahr 3288 3 impairment impairment NN cord-028721-x6f26ahr 3288 4 of of IN cord-028721-x6f26ahr 3288 5 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3288 6 and and CC cord-028721-x6f26ahr 3288 7 subfertility subfertility NN cord-028721-x6f26ahr 3288 8 . . . cord-028721-x6f26ahr 3289 1 Spermiogram Spermiogram NNP cord-028721-x6f26ahr 3289 2 parameters parameter NNS cord-028721-x6f26ahr 3289 3 improve improve VBP cord-028721-x6f26ahr 3289 4 when when WRB cord-028721-x6f26ahr 3289 5 treatment treatment NN cord-028721-x6f26ahr 3289 6 ceases cease VBZ cord-028721-x6f26ahr 3289 7 . . . cord-028721-x6f26ahr 3290 1 More More JJR cord-028721-x6f26ahr 3290 2 than than IN cord-028721-x6f26ahr 3290 3 17 17 CD cord-028721-x6f26ahr 3290 4 % % NN cord-028721-x6f26ahr 3290 5 of of IN cord-028721-x6f26ahr 3290 6 HIV HIV NNP cord-028721-x6f26ahr 3290 7 - - HYPH cord-028721-x6f26ahr 3290 8 infected infect VBN cord-028721-x6f26ahr 3290 9 men man NNS cord-028721-x6f26ahr 3290 10 have have VBP cord-028721-x6f26ahr 3290 11 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3290 12 , , , cord-028721-x6f26ahr 3290 13 1378 1378 CD cord-028721-x6f26ahr 3290 14 which which WDT cord-028721-x6f26ahr 3290 15 can can MD cord-028721-x6f26ahr 3290 16 be be VB cord-028721-x6f26ahr 3290 17 observed observe VBN cord-028721-x6f26ahr 3290 18 even even RB cord-028721-x6f26ahr 3290 19 in in IN cord-028721-x6f26ahr 3290 20 those those DT cord-028721-x6f26ahr 3290 21 whose whose WP$ cord-028721-x6f26ahr 3290 22 viral viral JJ cord-028721-x6f26ahr 3290 23 replication replication NN cord-028721-x6f26ahr 3290 24 is be VBZ cord-028721-x6f26ahr 3290 25 under under IN cord-028721-x6f26ahr 3290 26 control control NN cord-028721-x6f26ahr 3290 27 and and CC cord-028721-x6f26ahr 3290 28 show show VB cord-028721-x6f26ahr 3290 29 normal normal JJ cord-028721-x6f26ahr 3290 30 numbers number NNS cord-028721-x6f26ahr 3290 31 of of IN cord-028721-x6f26ahr 3290 32 CD4 CD4 NNP cord-028721-x6f26ahr 3290 33 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3290 34 . . . cord-028721-x6f26ahr 3291 1 Patients patient NNS cord-028721-x6f26ahr 3291 2 frequently frequently RB cord-028721-x6f26ahr 3291 3 develop develop VBP cord-028721-x6f26ahr 3291 4 ' ' `` cord-028721-x6f26ahr 3291 5 early early JJ cord-028721-x6f26ahr 3291 6 andropause andropause NN cord-028721-x6f26ahr 3291 7 , , , cord-028721-x6f26ahr 3291 8 ' ' '' cord-028721-x6f26ahr 3291 9 marked mark VBN cord-028721-x6f26ahr 3291 10 by by IN cord-028721-x6f26ahr 3291 11 dysregulation dysregulation NN cord-028721-x6f26ahr 3291 12 of of IN cord-028721-x6f26ahr 3291 13 the the DT cord-028721-x6f26ahr 3291 14 hypothalamopituitary hypothalamopituitary JJ cord-028721-x6f26ahr 3291 15 - - HYPH cord-028721-x6f26ahr 3291 16 testicular testicular JJ cord-028721-x6f26ahr 3291 17 axis axis NN cord-028721-x6f26ahr 3291 18 . . . cord-028721-x6f26ahr 3292 1 1379 1379 CD cord-028721-x6f26ahr 3292 2 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 3292 3 is be VBZ cord-028721-x6f26ahr 3292 4 more more RBR cord-028721-x6f26ahr 3292 5 frequent frequent JJ cord-028721-x6f26ahr 3292 6 in in IN cord-028721-x6f26ahr 3292 7 HIV HIV NNP cord-028721-x6f26ahr 3292 8 - - HYPH cord-028721-x6f26ahr 3292 9 infected infect VBN cord-028721-x6f26ahr 3292 10 men man NNS cord-028721-x6f26ahr 3292 11 with with IN cord-028721-x6f26ahr 3292 12 wasting waste VBG cord-028721-x6f26ahr 3292 13 syndrome syndrome NN cord-028721-x6f26ahr 3292 14 , , , cord-028721-x6f26ahr 3292 15 and and CC cord-028721-x6f26ahr 3292 16 therefore therefore RB cord-028721-x6f26ahr 3292 17 these these DT cord-028721-x6f26ahr 3292 18 patients patient NNS cord-028721-x6f26ahr 3292 19 should should MD cord-028721-x6f26ahr 3292 20 undergo undergo VB cord-028721-x6f26ahr 3292 21 screening screening NN cord-028721-x6f26ahr 3292 22 for for IN cord-028721-x6f26ahr 3292 23 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3292 24 and and CC cord-028721-x6f26ahr 3292 25 , , , cord-028721-x6f26ahr 3292 26 if if IN cord-028721-x6f26ahr 3292 27 necessary necessary JJ cord-028721-x6f26ahr 3292 28 , , , cord-028721-x6f26ahr 3292 29 physiologic physiologic JJ cord-028721-x6f26ahr 3292 30 androgen androgen NN cord-028721-x6f26ahr 3292 31 replacement replacement NN cord-028721-x6f26ahr 3292 32 therapy therapy NN cord-028721-x6f26ahr 3292 33 . . . cord-028721-x6f26ahr 3293 1 [ [ -LRB- cord-028721-x6f26ahr 3293 2 1380 1380 CD cord-028721-x6f26ahr 3293 3 ] ] -RRB- cord-028721-x6f26ahr 3293 4 [ [ -LRB- cord-028721-x6f26ahr 3293 5 1381 1381 CD cord-028721-x6f26ahr 3293 6 ] ] -RRB- cord-028721-x6f26ahr 3294 1 [ [ -LRB- cord-028721-x6f26ahr 3294 2 1382 1382 CD cord-028721-x6f26ahr 3294 3 ] ] -RRB- cord-028721-x6f26ahr 3295 1 [ [ -LRB- cord-028721-x6f26ahr 3295 2 1383 1383 CD cord-028721-x6f26ahr 3295 3 ] ] -RRB- cord-028721-x6f26ahr 3296 1 The the DT cord-028721-x6f26ahr 3296 2 incidence incidence NN cord-028721-x6f26ahr 3296 3 of of IN cord-028721-x6f26ahr 3296 4 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3296 5 in in IN cord-028721-x6f26ahr 3296 6 males male NNS cord-028721-x6f26ahr 3296 7 with with IN cord-028721-x6f26ahr 3296 8 AIDS AIDS NNP cord-028721-x6f26ahr 3296 9 is be VBZ cord-028721-x6f26ahr 3296 10 estimated estimate VBN cord-028721-x6f26ahr 3296 11 to to TO cord-028721-x6f26ahr 3296 12 be be VB cord-028721-x6f26ahr 3296 13 50 50 CD cord-028721-x6f26ahr 3296 14 % % NN cord-028721-x6f26ahr 3296 15 . . . cord-028721-x6f26ahr 3297 1 1384 1384 CD cord-028721-x6f26ahr 3297 2 , , , cord-028721-x6f26ahr 3297 3 1385 1385 CD cord-028721-x6f26ahr 3298 1 According accord VBG cord-028721-x6f26ahr 3298 2 to to IN cord-028721-x6f26ahr 3298 3 autopsy autopsy JJ cord-028721-x6f26ahr 3298 4 studies study NNS cord-028721-x6f26ahr 3298 5 this this DT cord-028721-x6f26ahr 3298 6 increases increase VBZ cord-028721-x6f26ahr 3298 7 to to IN cord-028721-x6f26ahr 3298 8 100 100 CD cord-028721-x6f26ahr 3298 9 % % NN cord-028721-x6f26ahr 3298 10 in in IN cord-028721-x6f26ahr 3298 11 the the DT cord-028721-x6f26ahr 3298 12 3 3 CD cord-028721-x6f26ahr 3298 13 - - SYM cord-028721-x6f26ahr 3298 14 24 24 CD cord-028721-x6f26ahr 3298 15 months month NNS cord-028721-x6f26ahr 3298 16 prior prior RB cord-028721-x6f26ahr 3298 17 to to IN cord-028721-x6f26ahr 3298 18 death death NN cord-028721-x6f26ahr 3298 19 . . . cord-028721-x6f26ahr 3299 1 1386 1386 CD cord-028721-x6f26ahr 3299 2 Histological Histological NNP cord-028721-x6f26ahr 3299 3 studies study NNS cord-028721-x6f26ahr 3299 4 reveal reveal VBP cord-028721-x6f26ahr 3299 5 that that IN cord-028721-x6f26ahr 3299 6 28 28 CD cord-028721-x6f26ahr 3299 7 % % NN cord-028721-x6f26ahr 3299 8 have have VBP cord-028721-x6f26ahr 3299 9 complete complete JJ cord-028721-x6f26ahr 3299 10 but but CC cord-028721-x6f26ahr 3299 11 quantitatively quantitatively RB cord-028721-x6f26ahr 3299 12 abnormal abnormal JJ cord-028721-x6f26ahr 3299 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3299 14 , , , cord-028721-x6f26ahr 3299 15 and and CC cord-028721-x6f26ahr 3299 16 the the DT cord-028721-x6f26ahr 3299 17 remainder remainder NN cord-028721-x6f26ahr 3299 18 have have VBP cord-028721-x6f26ahr 3299 19 spermatocytic spermatocytic VBN cord-028721-x6f26ahr 3299 20 arrest arrest NN cord-028721-x6f26ahr 3299 21 or or CC cord-028721-x6f26ahr 3299 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 3299 23 cell cell NN cord-028721-x6f26ahr 3299 24 - - HYPH cord-028721-x6f26ahr 3299 25 only only RB cord-028721-x6f26ahr 3299 26 pattern pattern NN cord-028721-x6f26ahr 3299 27 . . . cord-028721-x6f26ahr 3300 1 Patients patient NNS cord-028721-x6f26ahr 3300 2 with with IN cord-028721-x6f26ahr 3300 3 chronic chronic JJ cord-028721-x6f26ahr 3300 4 anemia anemia NN cord-028721-x6f26ahr 3300 5 requiring require VBG cord-028721-x6f26ahr 3300 6 multiple multiple JJ cord-028721-x6f26ahr 3300 7 transfusions transfusion NNS cord-028721-x6f26ahr 3300 8 develop develop VB cord-028721-x6f26ahr 3300 9 iron iron NN cord-028721-x6f26ahr 3300 10 deposits deposit NNS cord-028721-x6f26ahr 3300 11 in in IN cord-028721-x6f26ahr 3300 12 the the DT cord-028721-x6f26ahr 3300 13 pituitary pituitary NN cord-028721-x6f26ahr 3300 14 and and CC cord-028721-x6f26ahr 3300 15 polyglandular polyglandular NNP cord-028721-x6f26ahr 3300 16 insuffi insuffi NNP cord-028721-x6f26ahr 3300 17 ciency ciency NNP cord-028721-x6f26ahr 3300 18 , , , cord-028721-x6f26ahr 3300 19 with with IN cord-028721-x6f26ahr 3300 20 atrophy atrophy NN cord-028721-x6f26ahr 3300 21 of of IN cord-028721-x6f26ahr 3300 22 the the DT cord-028721-x6f26ahr 3300 23 thyroid thyroid NN cord-028721-x6f26ahr 3300 24 , , , cord-028721-x6f26ahr 3300 25 adrenals adrenal NNS cord-028721-x6f26ahr 3300 26 , , , cord-028721-x6f26ahr 3300 27 and and CC cord-028721-x6f26ahr 3300 28 testes testis NNS cord-028721-x6f26ahr 3300 29 ( ( -LRB- cord-028721-x6f26ahr 3300 30 Fig Fig NNP cord-028721-x6f26ahr 3300 31 . . . cord-028721-x6f26ahr 3300 32 12 12 CD cord-028721-x6f26ahr 3300 33 - - SYM cord-028721-x6f26ahr 3300 34 149 149 CD cord-028721-x6f26ahr 3300 35 ) ) -RRB- cord-028721-x6f26ahr 3300 36 . . . cord-028721-x6f26ahr 3301 1 The the DT cord-028721-x6f26ahr 3301 2 most most RBS cord-028721-x6f26ahr 3301 3 frequent frequent JJ cord-028721-x6f26ahr 3301 4 conditions condition NNS cord-028721-x6f26ahr 3301 5 are be VBP cord-028721-x6f26ahr 3301 6 βthalassemia βthalassemia NN cord-028721-x6f26ahr 3301 7 and and CC cord-028721-x6f26ahr 3301 8 sickle sickle NN cord-028721-x6f26ahr 3301 9 cell cell NN cord-028721-x6f26ahr 3301 10 anemia anemia NN cord-028721-x6f26ahr 3301 11 ( ( -LRB- cord-028721-x6f26ahr 3301 12 see see VB cord-028721-x6f26ahr 3301 13 Fig Fig NNP cord-028721-x6f26ahr 3301 14 . . . cord-028721-x6f26ahr 3301 15 12 12 CD cord-028721-x6f26ahr 3301 16 - - SYM cord-028721-x6f26ahr 3301 17 119 119 CD cord-028721-x6f26ahr 3301 18 ) ) -RRB- cord-028721-x6f26ahr 3301 19 . . . cord-028721-x6f26ahr 3302 1 β β NN cord-028721-x6f26ahr 3302 2 - - HYPH cord-028721-x6f26ahr 3302 3 Thalassemia Thalassemia NNP cord-028721-x6f26ahr 3302 4 is be VBZ cord-028721-x6f26ahr 3302 5 an an DT cord-028721-x6f26ahr 3302 6 autosomal autosomal JJ cord-028721-x6f26ahr 3302 7 dominant dominant JJ cord-028721-x6f26ahr 3302 8 disease disease NN cord-028721-x6f26ahr 3302 9 with with IN cord-028721-x6f26ahr 3302 10 three three CD cord-028721-x6f26ahr 3302 11 types type NNS cord-028721-x6f26ahr 3302 12 : : : cord-028721-x6f26ahr 3302 13 thalassemia thalassemia NN cord-028721-x6f26ahr 3302 14 trait trait NN cord-028721-x6f26ahr 3302 15 ( ( -LRB- cord-028721-x6f26ahr 3302 16 heterozygous heterozygous JJ cord-028721-x6f26ahr 3302 17 β β NN cord-028721-x6f26ahr 3302 18 - - HYPH cord-028721-x6f26ahr 3302 19 thalassemia thalassemia NN cord-028721-x6f26ahr 3302 20 ) ) -RRB- cord-028721-x6f26ahr 3302 21 , , , cord-028721-x6f26ahr 3302 22 intermediate intermediate JJ cord-028721-x6f26ahr 3302 23 thalassemia thalassemia NN cord-028721-x6f26ahr 3302 24 , , , cord-028721-x6f26ahr 3302 25 and and CC cord-028721-x6f26ahr 3302 26 major major JJ cord-028721-x6f26ahr 3302 27 β β NN cord-028721-x6f26ahr 3302 28 - - HYPH cord-028721-x6f26ahr 3302 29 thalassemia thalassemia NN cord-028721-x6f26ahr 3302 30 . . . cord-028721-x6f26ahr 3303 1 The the DT cord-028721-x6f26ahr 3303 2 cause cause NN cord-028721-x6f26ahr 3303 3 is be VBZ cord-028721-x6f26ahr 3303 4 mutation mutation NN cord-028721-x6f26ahr 3303 5 in in IN cord-028721-x6f26ahr 3303 6 the the DT cord-028721-x6f26ahr 3303 7 β β NN cord-028721-x6f26ahr 3303 8 - - HYPH cord-028721-x6f26ahr 3303 9 globin globin NN cord-028721-x6f26ahr 3303 10 gene gene NN cord-028721-x6f26ahr 3303 11 resulting result VBG cord-028721-x6f26ahr 3303 12 in in IN cord-028721-x6f26ahr 3303 13 ineffective ineffective JJ cord-028721-x6f26ahr 3303 14 erythropoiesis erythropoiesis NN cord-028721-x6f26ahr 3303 15 , , , cord-028721-x6f26ahr 3303 16 hemolysis hemolysis NN cord-028721-x6f26ahr 3303 17 , , , cord-028721-x6f26ahr 3303 18 and and CC cord-028721-x6f26ahr 3303 19 anemia anemia NN cord-028721-x6f26ahr 3303 20 . . . cord-028721-x6f26ahr 3304 1 Nearly nearly RB cord-028721-x6f26ahr 3304 2 20 20 CD cord-028721-x6f26ahr 3304 3 % % NN cord-028721-x6f26ahr 3304 4 of of IN cord-028721-x6f26ahr 3304 5 patients patient NNS cord-028721-x6f26ahr 3304 6 with with IN cord-028721-x6f26ahr 3304 7 major major JJ cord-028721-x6f26ahr 3304 8 thalassemia thalassemia NN cord-028721-x6f26ahr 3304 9 have have VBP cord-028721-x6f26ahr 3304 10 delayed delay VBN cord-028721-x6f26ahr 3304 11 puberty puberty NN cord-028721-x6f26ahr 3304 12 , , , cord-028721-x6f26ahr 3304 13 [ [ -LRB- cord-028721-x6f26ahr 3304 14 1387 1387 CD cord-028721-x6f26ahr 3304 15 ] ] -RRB- cord-028721-x6f26ahr 3304 16 [ [ -LRB- cord-028721-x6f26ahr 3304 17 1388 1388 CD cord-028721-x6f26ahr 3304 18 ] ] -RRB- cord-028721-x6f26ahr 3304 19 [ [ -LRB- cord-028721-x6f26ahr 3304 20 1389 1389 CD cord-028721-x6f26ahr 3304 21 ] ] -RRB- cord-028721-x6f26ahr 3304 22 and and CC cord-028721-x6f26ahr 3304 23 69 69 CD cord-028721-x6f26ahr 3304 24 % % NN cord-028721-x6f26ahr 3304 25 have have VBP cord-028721-x6f26ahr 3304 26 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3304 27 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3304 28 . . . cord-028721-x6f26ahr 3305 1 1390 1390 CD cord-028721-x6f26ahr 3306 1 Gonadal Gonadal NNP cord-028721-x6f26ahr 3306 2 dysfunction dysfunction NN cord-028721-x6f26ahr 3306 3 persists persist VBZ cord-028721-x6f26ahr 3306 4 in in IN cord-028721-x6f26ahr 3306 5 most most JJS cord-028721-x6f26ahr 3306 6 patients patient NNS cord-028721-x6f26ahr 3306 7 after after IN cord-028721-x6f26ahr 3306 8 healing healing NN cord-028721-x6f26ahr 3306 9 of of IN cord-028721-x6f26ahr 3306 10 the the DT cord-028721-x6f26ahr 3306 11 thalassemia thalassemia NN cord-028721-x6f26ahr 3306 12 . . . cord-028721-x6f26ahr 3307 1 1391 1391 CD cord-028721-x6f26ahr 3307 2 Sickle Sickle NNP cord-028721-x6f26ahr 3307 3 cell cell NN cord-028721-x6f26ahr 3307 4 anemia anemia NN cord-028721-x6f26ahr 3307 5 is be VBZ cord-028721-x6f26ahr 3307 6 an an DT cord-028721-x6f26ahr 3307 7 autosomal autosomal JJ cord-028721-x6f26ahr 3307 8 recessive recessive JJ cord-028721-x6f26ahr 3307 9 disorder disorder NN cord-028721-x6f26ahr 3307 10 with with IN cord-028721-x6f26ahr 3307 11 a a DT cord-028721-x6f26ahr 3307 12 constellation constellation NN cord-028721-x6f26ahr 3307 13 of of IN cord-028721-x6f26ahr 3307 14 fi fi NN cord-028721-x6f26ahr 3307 15 ndings nding NNS cord-028721-x6f26ahr 3307 16 resulting result VBG cord-028721-x6f26ahr 3307 17 from from IN cord-028721-x6f26ahr 3307 18 abnormal abnormal JJ cord-028721-x6f26ahr 3307 19 synthesis synthesis NN cord-028721-x6f26ahr 3307 20 of of IN cord-028721-x6f26ahr 3307 21 hemoglobin hemoglobin NN cord-028721-x6f26ahr 3307 22 , , , cord-028721-x6f26ahr 3307 23 with with IN cord-028721-x6f26ahr 3307 24 over over IN cord-028721-x6f26ahr 3307 25 90 90 CD cord-028721-x6f26ahr 3307 26 % % NN cord-028721-x6f26ahr 3307 27 of of IN cord-028721-x6f26ahr 3307 28 hemoglobin hemoglobin NN cord-028721-x6f26ahr 3307 29 being being NN cord-028721-x6f26ahr 3307 30 type type NN cord-028721-x6f26ahr 3308 1 A. a. LS cord-028721-x6f26ahr 3308 2 Most Most JJS cord-028721-x6f26ahr 3308 3 patients patient NNS cord-028721-x6f26ahr 3308 4 have have VBP cord-028721-x6f26ahr 3308 5 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3308 6 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3308 7 . . . cord-028721-x6f26ahr 3309 1 1392 1392 CD cord-028721-x6f26ahr 3310 1 The the DT cord-028721-x6f26ahr 3310 2 majority majority NN cord-028721-x6f26ahr 3310 3 of of IN cord-028721-x6f26ahr 3310 4 people people NNS cord-028721-x6f26ahr 3310 5 in in IN cord-028721-x6f26ahr 3310 6 developed develop VBN cord-028721-x6f26ahr 3310 7 countries country NNS cord-028721-x6f26ahr 3310 8 are be VBP cord-028721-x6f26ahr 3310 9 currently currently RB cord-028721-x6f26ahr 3310 10 overweight overweight JJ cord-028721-x6f26ahr 3310 11 , , , cord-028721-x6f26ahr 3310 12 and and CC cord-028721-x6f26ahr 3310 13 the the DT cord-028721-x6f26ahr 3310 14 incidence incidence NN cord-028721-x6f26ahr 3310 15 of of IN cord-028721-x6f26ahr 3310 16 obesity obesity NN cord-028721-x6f26ahr 3310 17 seems seem VBZ cord-028721-x6f26ahr 3310 18 to to TO cord-028721-x6f26ahr 3310 19 be be VB cord-028721-x6f26ahr 3310 20 increasing increase VBG cord-028721-x6f26ahr 3310 21 . . . cord-028721-x6f26ahr 3311 1 Infertility infertility NN cord-028721-x6f26ahr 3311 2 is be VBZ cord-028721-x6f26ahr 3311 3 frequently frequently RB cord-028721-x6f26ahr 3311 4 associated associate VBN cord-028721-x6f26ahr 3311 5 with with IN cord-028721-x6f26ahr 3311 6 obesity obesity NN cord-028721-x6f26ahr 3311 7 . . . cord-028721-x6f26ahr 3312 1 Very very RB cord-028721-x6f26ahr 3312 2 obese obese JJ cord-028721-x6f26ahr 3312 3 males male NNS cord-028721-x6f26ahr 3312 4 have have VBP cord-028721-x6f26ahr 3312 5 increased increase VBN cord-028721-x6f26ahr 3312 6 levels level NNS cord-028721-x6f26ahr 3312 7 of of IN cord-028721-x6f26ahr 3312 8 serum serum NN cord-028721-x6f26ahr 3312 9 estradiol estradiol NN cord-028721-x6f26ahr 3312 10 and and CC cord-028721-x6f26ahr 3312 11 decreased decrease VBD cord-028721-x6f26ahr 3312 12 levels level NNS cord-028721-x6f26ahr 3312 13 of of IN cord-028721-x6f26ahr 3312 14 free free JJ cord-028721-x6f26ahr 3312 15 testosterone testosterone NN cord-028721-x6f26ahr 3312 16 and and CC cord-028721-x6f26ahr 3312 17 inhibin inhibin NNP cord-028721-x6f26ahr 3312 18 B. B. NNP cord-028721-x6f26ahr 3312 19 1393 1393 CD cord-028721-x6f26ahr 3313 1 Testosterone testosterone NN cord-028721-x6f26ahr 3313 2 reduction reduction NN cord-028721-x6f26ahr 3313 3 is be VBZ cord-028721-x6f26ahr 3313 4 not not RB cord-028721-x6f26ahr 3313 5 followed follow VBN cord-028721-x6f26ahr 3313 6 by by IN cord-028721-x6f26ahr 3313 7 a a DT cord-028721-x6f26ahr 3313 8 compensatory compensatory JJ cord-028721-x6f26ahr 3313 9 increase increase NN cord-028721-x6f26ahr 3313 10 in in IN cord-028721-x6f26ahr 3313 11 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 3313 12 , , , cord-028721-x6f26ahr 3313 13 resulting result VBG cord-028721-x6f26ahr 3313 14 in in IN cord-028721-x6f26ahr 3313 15 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3313 16 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3313 17 . . . cord-028721-x6f26ahr 3314 1 1394 1394 CD cord-028721-x6f26ahr 3314 2 , , , cord-028721-x6f26ahr 3314 3 1395 1395 CD cord-028721-x6f26ahr 3314 4 Testicular Testicular NNP cord-028721-x6f26ahr 3314 5 abnormalities abnormality NNS cord-028721-x6f26ahr 3314 6 begin begin VBP cord-028721-x6f26ahr 3314 7 with with IN cord-028721-x6f26ahr 3314 8 the the DT cord-028721-x6f26ahr 3314 9 adluminal adluminal NNP cord-028721-x6f26ahr 3314 10 compartment compartment NNP cord-028721-x6f26ahr 3314 11 and and CC cord-028721-x6f26ahr 3314 12 later later RB cord-028721-x6f26ahr 3314 13 involve involve VBP cord-028721-x6f26ahr 3314 14 the the DT cord-028721-x6f26ahr 3314 15 basal basal NN cord-028721-x6f26ahr 3314 16 compartment compartment NN cord-028721-x6f26ahr 3314 17 ; ; : cord-028721-x6f26ahr 3314 18 also also RB cord-028721-x6f26ahr 3314 19 , , , cord-028721-x6f26ahr 3314 20 there there EX cord-028721-x6f26ahr 3314 21 are be VBP cord-028721-x6f26ahr 3314 22 Leydig leydig NN cord-028721-x6f26ahr 3314 23 cell cell NN cord-028721-x6f26ahr 3314 24 atrophy atrophy NN cord-028721-x6f26ahr 3314 25 , , , cord-028721-x6f26ahr 3314 26 cuboidal cuboidal JJ cord-028721-x6f26ahr 3314 27 metaplasia metaplasia NN cord-028721-x6f26ahr 3314 28 of of IN cord-028721-x6f26ahr 3314 29 the the DT cord-028721-x6f26ahr 3314 30 rete rete NNP cord-028721-x6f26ahr 3314 31 testis testis NN cord-028721-x6f26ahr 3314 32 , , , cord-028721-x6f26ahr 3314 33 and and CC cord-028721-x6f26ahr 3314 34 epididymal epididymal JJ cord-028721-x6f26ahr 3314 35 atrophy atrophy NN cord-028721-x6f26ahr 3314 36 . . . cord-028721-x6f26ahr 3315 1 There there EX cord-028721-x6f26ahr 3315 2 are be VBP cord-028721-x6f26ahr 3315 3 three three CD cord-028721-x6f26ahr 3315 4 types type NNS cord-028721-x6f26ahr 3315 5 of of IN cord-028721-x6f26ahr 3315 6 autoimmune autoimmune JJ cord-028721-x6f26ahr 3315 7 polyglandular polyglandular NNP cord-028721-x6f26ahr 3315 8 insufficiency insufficiency NNP cord-028721-x6f26ahr 3315 9 syndrome syndrome NN cord-028721-x6f26ahr 3315 10 . . . cord-028721-x6f26ahr 3316 1 Type type NN cord-028721-x6f26ahr 3317 1 I -PRON- PRP cord-028721-x6f26ahr 3317 2 is be VBZ cord-028721-x6f26ahr 3317 3 defi defi NNP cord-028721-x6f26ahr 3317 4 ned ned NNP cord-028721-x6f26ahr 3317 5 by by IN cord-028721-x6f26ahr 3317 6 the the DT cord-028721-x6f26ahr 3317 7 presence presence NN cord-028721-x6f26ahr 3317 8 of of IN cord-028721-x6f26ahr 3317 9 at at RB cord-028721-x6f26ahr 3317 10 least least RBS cord-028721-x6f26ahr 3317 11 two two CD cord-028721-x6f26ahr 3317 12 of of IN cord-028721-x6f26ahr 3317 13 three three CD cord-028721-x6f26ahr 3317 14 characteristic characteristic JJ cord-028721-x6f26ahr 3317 15 features feature NNS cord-028721-x6f26ahr 3317 16 : : : cord-028721-x6f26ahr 3317 17 Addison Addison NNP cord-028721-x6f26ahr 3317 18 's 's POS cord-028721-x6f26ahr 3317 19 disease disease NN cord-028721-x6f26ahr 3317 20 , , , cord-028721-x6f26ahr 3317 21 hypoparathyroidism hypoparathyroidism NN cord-028721-x6f26ahr 3317 22 , , , cord-028721-x6f26ahr 3317 23 and and CC cord-028721-x6f26ahr 3317 24 chronic chronic JJ cord-028721-x6f26ahr 3317 25 mucocutaneous mucocutaneous JJ cord-028721-x6f26ahr 3317 26 candidiasis candidiasi NNS cord-028721-x6f26ahr 3317 27 . . . cord-028721-x6f26ahr 3318 1 The the DT cord-028721-x6f26ahr 3318 2 AIRE AIRE NNP cord-028721-x6f26ahr 3318 3 gene gene NN cord-028721-x6f26ahr 3318 4 ( ( -LRB- cord-028721-x6f26ahr 3318 5 autoimmune autoimmune JJ cord-028721-x6f26ahr 3318 6 regulator regulator NN cord-028721-x6f26ahr 3318 7 ) ) -RRB- cord-028721-x6f26ahr 3318 8 , , , cord-028721-x6f26ahr 3318 9 responsible responsible JJ cord-028721-x6f26ahr 3318 10 for for IN cord-028721-x6f26ahr 3318 11 type type NN cord-028721-x6f26ahr 3318 12 l l NNP cord-028721-x6f26ahr 3318 13 disease disease NN cord-028721-x6f26ahr 3318 14 , , , cord-028721-x6f26ahr 3318 15 is be VBZ cord-028721-x6f26ahr 3318 16 on on IN cord-028721-x6f26ahr 3318 17 21q22.3 21q22.3 CD cord-028721-x6f26ahr 3318 18 , , , cord-028721-x6f26ahr 3318 19 1396,1397 1396,1397 CD cord-028721-x6f26ahr 3318 20 and and CC cord-028721-x6f26ahr 3318 21 the the DT cord-028721-x6f26ahr 3318 22 disorder disorder NN cord-028721-x6f26ahr 3318 23 is be VBZ cord-028721-x6f26ahr 3318 24 recessive recessive JJ cord-028721-x6f26ahr 3318 25 autosomal autosomal JJ cord-028721-x6f26ahr 3318 26 . . . cord-028721-x6f26ahr 3319 1 Hypergonadotropic Hypergonadotropic NNP cord-028721-x6f26ahr 3319 2 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3319 3 is be VBZ cord-028721-x6f26ahr 3319 4 frequent frequent JJ cord-028721-x6f26ahr 3319 5 . . . cord-028721-x6f26ahr 3320 1 1398 1398 CD cord-028721-x6f26ahr 3320 2 Patients patient NNS cord-028721-x6f26ahr 3320 3 with with IN cord-028721-x6f26ahr 3320 4 type type NN cord-028721-x6f26ahr 3320 5 I -PRON- PRP cord-028721-x6f26ahr 3320 6 syndrome syndrome NN cord-028721-x6f26ahr 3320 7 have have VBP cord-028721-x6f26ahr 3320 8 antibodies antibody NNS cord-028721-x6f26ahr 3320 9 against against IN cord-028721-x6f26ahr 3320 10 many many JJ cord-028721-x6f26ahr 3320 11 autoantigens autoantigen NNS cord-028721-x6f26ahr 3320 12 , , , cord-028721-x6f26ahr 3320 13 intracellular intracellular JJ cord-028721-x6f26ahr 3320 14 enzymes enzyme NNS cord-028721-x6f26ahr 3320 15 including include VBG cord-028721-x6f26ahr 3320 16 the the DT cord-028721-x6f26ahr 3320 17 P450 p450 JJ cord-028721-x6f26ahr 3320 18 side side NN cord-028721-x6f26ahr 3320 19 - - HYPH cord-028721-x6f26ahr 3320 20 chain chain NN cord-028721-x6f26ahr 3320 21 cleavage cleavage NN cord-028721-x6f26ahr 3320 22 enzyme enzyme NN cord-028721-x6f26ahr 3320 23 , , , cord-028721-x6f26ahr 3320 24 17α 17α CD cord-028721-x6f26ahr 3320 25 - - HYPH cord-028721-x6f26ahr 3320 26 hydroxylase hydroxylase NN cord-028721-x6f26ahr 3320 27 1399 1399 CD cord-028721-x6f26ahr 3320 28 , , , cord-028721-x6f26ahr 3320 29 1400 1400 CD cord-028721-x6f26ahr 3320 30 and and CC cord-028721-x6f26ahr 3320 31 21-hydroxylase 21-hydroxylase CD cord-028721-x6f26ahr 3320 32 , , , cord-028721-x6f26ahr 3320 33 glutamic glutamic NN cord-028721-x6f26ahr 3320 34 acid acid NN cord-028721-x6f26ahr 3320 35 decarboxylase decarboxylase NNP cord-028721-x6f26ahr 3320 36 65 65 CD cord-028721-x6f26ahr 3320 37 , , , cord-028721-x6f26ahr 3320 38 aromatic aromatic JJ cord-028721-x6f26ahr 3320 39 L l NN cord-028721-x6f26ahr 3320 40 - - HYPH cord-028721-x6f26ahr 3320 41 amino amino NN cord-028721-x6f26ahr 3320 42 acid acid NN cord-028721-x6f26ahr 3320 43 decarboxylase decarboxylase NN cord-028721-x6f26ahr 3320 44 , , , cord-028721-x6f26ahr 3320 45 tyrosine tyrosine NN cord-028721-x6f26ahr 3320 46 phosphataselike phosphataselike JJ cord-028721-x6f26ahr 3320 47 protein protein NN cord-028721-x6f26ahr 3320 48 IA-2 IA-2 NNP cord-028721-x6f26ahr 3320 49 , , , cord-028721-x6f26ahr 3321 1 tryptophan tryptophan NN cord-028721-x6f26ahr 3321 2 hydroxylase hydroxylase NN cord-028721-x6f26ahr 3321 3 ( ( -LRB- cord-028721-x6f26ahr 3321 4 TPH TPH NNP cord-028721-x6f26ahr 3321 5 ) ) -RRB- cord-028721-x6f26ahr 3321 6 , , , cord-028721-x6f26ahr 3321 7 tyrosine tyrosine NN cord-028721-x6f26ahr 3321 8 hydroxylase hydroxylase NN cord-028721-x6f26ahr 3321 9 , , , cord-028721-x6f26ahr 3321 10 and and CC cord-028721-x6f26ahr 3321 11 cytochrome cytochrome NN cord-028721-x6f26ahr 3321 12 P450 p450 JJ cord-028721-x6f26ahr 3321 13 1A2 1a2 CD cord-028721-x6f26ahr 3321 14 . . . cord-028721-x6f26ahr 3322 1 1401 1401 CD cord-028721-x6f26ahr 3322 2 Type Type NNP cord-028721-x6f26ahr 3322 3 II II NNP cord-028721-x6f26ahr 3322 4 autoimmune autoimmune JJ cord-028721-x6f26ahr 3322 5 polyglandular polyglandular NNP cord-028721-x6f26ahr 3322 6 syndrome syndrome NN cord-028721-x6f26ahr 3322 7 is be VBZ cord-028721-x6f26ahr 3322 8 characterized characterize VBN cord-028721-x6f26ahr 3322 9 by by IN cord-028721-x6f26ahr 3322 10 the the DT cord-028721-x6f26ahr 3322 11 presence presence NN cord-028721-x6f26ahr 3322 12 of of IN cord-028721-x6f26ahr 3322 13 diabetes diabetes NN cord-028721-x6f26ahr 3322 14 mellitus mellitus NN cord-028721-x6f26ahr 3322 15 , , , cord-028721-x6f26ahr 3322 16 hyperthyroid- hyperthyroid- XX cord-028721-x6f26ahr 3323 1 Infertility infertility NN cord-028721-x6f26ahr 3323 2 ism ism NN cord-028721-x6f26ahr 3323 3 , , , cord-028721-x6f26ahr 3323 4 Hashimoto Hashimoto NNP cord-028721-x6f26ahr 3323 5 's 's POS cord-028721-x6f26ahr 3323 6 thyroiditis thyroiditis NN cord-028721-x6f26ahr 3323 7 , , , cord-028721-x6f26ahr 3323 8 Addison Addison NNP cord-028721-x6f26ahr 3323 9 's 's POS cord-028721-x6f26ahr 3323 10 disease disease NN cord-028721-x6f26ahr 3323 11 , , , cord-028721-x6f26ahr 3323 12 vitiligo vitiligo NN cord-028721-x6f26ahr 3323 13 , , , cord-028721-x6f26ahr 3323 14 alopecia alopecia NN cord-028721-x6f26ahr 3323 15 , , , cord-028721-x6f26ahr 3323 16 pernicious pernicious JJ cord-028721-x6f26ahr 3323 17 anemia anemia NN cord-028721-x6f26ahr 3323 18 , , , cord-028721-x6f26ahr 3323 19 and and CC cord-028721-x6f26ahr 3323 20 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3323 21 ( ( -LRB- cord-028721-x6f26ahr 3323 22 listed list VBN cord-028721-x6f26ahr 3323 23 in in IN cord-028721-x6f26ahr 3323 24 decreasing decrease VBG cord-028721-x6f26ahr 3323 25 order order NN cord-028721-x6f26ahr 3323 26 of of IN cord-028721-x6f26ahr 3323 27 frequency frequency NN cord-028721-x6f26ahr 3323 28 ) ) -RRB- cord-028721-x6f26ahr 3323 29 . . . cord-028721-x6f26ahr 3324 1 Type Type NNP cord-028721-x6f26ahr 3324 2 III III NNP cord-028721-x6f26ahr 3324 3 syndrome syndrome NN cord-028721-x6f26ahr 3324 4 includes include VBZ cord-028721-x6f26ahr 3324 5 thyroiditis thyroiditis NN cord-028721-x6f26ahr 3324 6 , , , cord-028721-x6f26ahr 3324 7 diabetes diabetes NN cord-028721-x6f26ahr 3324 8 mellitus mellitus NN cord-028721-x6f26ahr 3324 9 , , , cord-028721-x6f26ahr 3324 10 pernicious pernicious JJ cord-028721-x6f26ahr 3324 11 anemia anemia NN cord-028721-x6f26ahr 3324 12 , , , cord-028721-x6f26ahr 3324 13 and and CC cord-028721-x6f26ahr 3324 14 vitiligo vitiligo NN cord-028721-x6f26ahr 3324 15 or or CC cord-028721-x6f26ahr 3324 16 alopecia alopecia NN cord-028721-x6f26ahr 3324 17 . . . cord-028721-x6f26ahr 3325 1 About about RB cord-028721-x6f26ahr 3325 2 14 14 CD cord-028721-x6f26ahr 3325 3 % % NN cord-028721-x6f26ahr 3325 4 of of IN cord-028721-x6f26ahr 3325 5 patients patient NNS cord-028721-x6f26ahr 3325 6 have have VBP cord-028721-x6f26ahr 3325 7 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3325 8 owing owe VBG cord-028721-x6f26ahr 3325 9 to to IN cord-028721-x6f26ahr 3325 10 autoimmune autoimmune JJ cord-028721-x6f26ahr 3325 11 destruction destruction NN cord-028721-x6f26ahr 3325 12 of of IN cord-028721-x6f26ahr 3325 13 the the DT cord-028721-x6f26ahr 3325 14 testis testis NN cord-028721-x6f26ahr 3325 15 or or CC cord-028721-x6f26ahr 3325 16 pituitary pituitary JJ cord-028721-x6f26ahr 3325 17 gonadotropin gonadotropin NN cord-028721-x6f26ahr 3325 18 - - HYPH cord-028721-x6f26ahr 3325 19 secreting secrete VBG cord-028721-x6f26ahr 3325 20 cells cell NNS cord-028721-x6f26ahr 3326 1 ( ( -LRB- cord-028721-x6f26ahr 3326 2 Fig Fig NNP cord-028721-x6f26ahr 3326 3 . . . cord-028721-x6f26ahr 3326 4 12 12 CD cord-028721-x6f26ahr 3326 5 - - SYM cord-028721-x6f26ahr 3326 6 150 150 CD cord-028721-x6f26ahr 3326 7 ) ) -RRB- cord-028721-x6f26ahr 3326 8 . . . cord-028721-x6f26ahr 3327 1 1402 1402 CD cord-028721-x6f26ahr 3327 2 , , , cord-028721-x6f26ahr 3327 3 1403 1403 CD cord-028721-x6f26ahr 3327 4 _SP cord-028721-x6f26ahr 3328 1 There there EX cord-028721-x6f26ahr 3328 2 are be VBP cord-028721-x6f26ahr 3328 3 at at IN cord-028721-x6f26ahr 3328 4 least least JJS cord-028721-x6f26ahr 3328 5 four four CD cord-028721-x6f26ahr 3328 6 diseases disease NNS cord-028721-x6f26ahr 3328 7 caused cause VBN cord-028721-x6f26ahr 3328 8 by by IN cord-028721-x6f26ahr 3328 9 metabolic metabolic JJ cord-028721-x6f26ahr 3328 10 deposits deposit NNS cord-028721-x6f26ahr 3328 11 in in IN cord-028721-x6f26ahr 3328 12 lysosomes lysosome NNS cord-028721-x6f26ahr 3328 13 or or CC cord-028721-x6f26ahr 3328 14 peroxisomes peroxisome NNS cord-028721-x6f26ahr 3328 15 associated associate VBN cord-028721-x6f26ahr 3328 16 with with IN cord-028721-x6f26ahr 3328 17 testicular testicular JJ cord-028721-x6f26ahr 3328 18 alterations alteration NNS cord-028721-x6f26ahr 3328 19 , , , cord-028721-x6f26ahr 3328 20 including include VBG cord-028721-x6f26ahr 3328 21 Fabry Fabry NNP cord-028721-x6f26ahr 3328 22 's 's POS cord-028721-x6f26ahr 3328 23 disease disease NN cord-028721-x6f26ahr 3328 24 , , , cord-028721-x6f26ahr 3328 25 adrenal adrenal JJ cord-028721-x6f26ahr 3328 26 leukodystrophy leukodystrophy NN cord-028721-x6f26ahr 3328 27 , , , cord-028721-x6f26ahr 3328 28 Wolman Wolman NNP cord-028721-x6f26ahr 3328 29 's 's POS cord-028721-x6f26ahr 3328 30 disease disease NN cord-028721-x6f26ahr 3328 31 , , , cord-028721-x6f26ahr 3328 32 and and CC cord-028721-x6f26ahr 3328 33 cystinosis cystinosis NNP cord-028721-x6f26ahr 3328 34 . . . cord-028721-x6f26ahr 3329 1 Fabry Fabry NNP cord-028721-x6f26ahr 3329 2 's 's POS cord-028721-x6f26ahr 3329 3 disease disease NN cord-028721-x6f26ahr 3329 4 is be VBZ cord-028721-x6f26ahr 3329 5 an an DT cord-028721-x6f26ahr 3329 6 X x NN cord-028721-x6f26ahr 3329 7 - - HYPH cord-028721-x6f26ahr 3329 8 linked link VBN cord-028721-x6f26ahr 3329 9 metabolic metabolic JJ cord-028721-x6f26ahr 3329 10 disorder disorder NN cord-028721-x6f26ahr 3329 11 characterized characterize VBN cord-028721-x6f26ahr 3329 12 by by IN cord-028721-x6f26ahr 3329 13 intralysosomal intralysosomal JJ cord-028721-x6f26ahr 3329 14 deposits deposit NNS cord-028721-x6f26ahr 3329 15 of of IN cord-028721-x6f26ahr 3329 16 globotriaosylceramide globotriaosylceramide NNP cord-028721-x6f26ahr 3329 17 ( ( -LRB- cord-028721-x6f26ahr 3329 18 Gb3 gb3 NN cord-028721-x6f26ahr 3329 19 ) ) -RRB- cord-028721-x6f26ahr 3329 20 owing owe VBG cord-028721-x6f26ahr 3329 21 to to IN cord-028721-x6f26ahr 3329 22 α α NN cord-028721-x6f26ahr 3329 23 - - HYPH cord-028721-x6f26ahr 3329 24 galactosidase galactosidase NN cord-028721-x6f26ahr 3329 25 defi defi NNP cord-028721-x6f26ahr 3329 26 ciency ciency NNP cord-028721-x6f26ahr 3329 27 . . . cord-028721-x6f26ahr 3330 1 Clinical clinical JJ cord-028721-x6f26ahr 3330 2 symptoms symptom NNS cord-028721-x6f26ahr 3330 3 begin begin VBP cord-028721-x6f26ahr 3330 4 with with IN cord-028721-x6f26ahr 3330 5 painful painful JJ cord-028721-x6f26ahr 3330 6 neuropathy neuropathy NN cord-028721-x6f26ahr 3330 7 and and CC cord-028721-x6f26ahr 3330 8 progressive progressive JJ cord-028721-x6f26ahr 3330 9 renal renal JJ cord-028721-x6f26ahr 3330 10 , , , cord-028721-x6f26ahr 3330 11 cardiovascular cardiovascular JJ cord-028721-x6f26ahr 3330 12 , , , cord-028721-x6f26ahr 3330 13 and and CC cord-028721-x6f26ahr 3330 14 cerebrovascular cerebrovascular JJ cord-028721-x6f26ahr 3330 15 dysfunction dysfunction NN cord-028721-x6f26ahr 3330 16 . . . cord-028721-x6f26ahr 3331 1 All all DT cord-028721-x6f26ahr 3331 2 endocrine endocrine JJ cord-028721-x6f26ahr 3331 3 glands gland NNS cord-028721-x6f26ahr 3331 4 may may MD cord-028721-x6f26ahr 3331 5 accumulate accumulate VB cord-028721-x6f26ahr 3331 6 Gb3 gb3 NN cord-028721-x6f26ahr 3331 7 as as IN cord-028721-x6f26ahr 3331 8 a a DT cord-028721-x6f26ahr 3331 9 result result NN cord-028721-x6f26ahr 3331 10 of of IN cord-028721-x6f26ahr 3331 11 welldeveloped welldeveloped NNS cord-028721-x6f26ahr 3331 12 vasculature vasculature NN cord-028721-x6f26ahr 3331 13 and and CC cord-028721-x6f26ahr 3331 14 low low JJ cord-028721-x6f26ahr 3331 15 rate rate NN cord-028721-x6f26ahr 3331 16 of of IN cord-028721-x6f26ahr 3331 17 cell cell NN cord-028721-x6f26ahr 3331 18 proliferation proliferation NN cord-028721-x6f26ahr 3331 19 . . . cord-028721-x6f26ahr 3332 1 1404 1404 CD cord-028721-x6f26ahr 3332 2 Testes testis NNS cord-028721-x6f26ahr 3332 3 and and CC cord-028721-x6f26ahr 3332 4 sperm sperm NN cord-028721-x6f26ahr 3332 5 excretory excretory JJ cord-028721-x6f26ahr 3332 6 ducts duct NNS cord-028721-x6f26ahr 3332 7 are be VBP cord-028721-x6f26ahr 3332 8 always always RB cord-028721-x6f26ahr 3332 9 damaged damage VBN cord-028721-x6f26ahr 3332 10 . . . cord-028721-x6f26ahr 3333 1 Some some DT cord-028721-x6f26ahr 3333 2 alterations alteration NNS cord-028721-x6f26ahr 3333 3 , , , cord-028721-x6f26ahr 3333 4 including include VBG cord-028721-x6f26ahr 3333 5 those those DT cord-028721-x6f26ahr 3333 6 of of IN cord-028721-x6f26ahr 3333 7 endothelial endothelial JJ cord-028721-x6f26ahr 3333 8 cells cell NNS cord-028721-x6f26ahr 3333 9 , , , cord-028721-x6f26ahr 3333 10 smooth smooth JJ cord-028721-x6f26ahr 3333 11 muscle muscle NN cord-028721-x6f26ahr 3333 12 cells cell NNS cord-028721-x6f26ahr 3333 13 , , , cord-028721-x6f26ahr 3333 14 and and CC cord-028721-x6f26ahr 3333 15 fi fi NNP cord-028721-x6f26ahr 3333 16 broblasts broblasts NNP cord-028721-x6f26ahr 3333 17 , , , cord-028721-x6f26ahr 3333 18 are be VBP cord-028721-x6f26ahr 3333 19 non non JJ cord-028721-x6f26ahr 3333 20 - - JJ cord-028721-x6f26ahr 3333 21 specifi specifi JJ cord-028721-x6f26ahr 3333 22 c c NN cord-028721-x6f26ahr 3333 23 ; ; : cord-028721-x6f26ahr 3333 24 others other NNS cord-028721-x6f26ahr 3333 25 , , , cord-028721-x6f26ahr 3333 26 such such JJ cord-028721-x6f26ahr 3333 27 as as IN cord-028721-x6f26ahr 3333 28 those those DT cord-028721-x6f26ahr 3333 29 of of IN cord-028721-x6f26ahr 3333 30 myofi myofi NNP cord-028721-x6f26ahr 3333 31 broblasts broblasts NNP cord-028721-x6f26ahr 3333 32 , , , cord-028721-x6f26ahr 3333 33 Leydig leydig NN cord-028721-x6f26ahr 3333 34 cells cell NNS cord-028721-x6f26ahr 3333 35 , , , cord-028721-x6f26ahr 3333 36 and and CC cord-028721-x6f26ahr 3333 37 epididymal epididymal JJ cord-028721-x6f26ahr 3333 38 epithelium epithelium NN cord-028721-x6f26ahr 3333 39 , , , cord-028721-x6f26ahr 3333 40 are be VBP cord-028721-x6f26ahr 3333 41 specifi specifi VBN cord-028721-x6f26ahr 3333 42 c c NN cord-028721-x6f26ahr 3334 1 ( ( -LRB- cord-028721-x6f26ahr 3334 2 Figs Figs NNP cord-028721-x6f26ahr 3334 3 12 12 CD cord-028721-x6f26ahr 3334 4 - - SYM cord-028721-x6f26ahr 3334 5 151 151 CD cord-028721-x6f26ahr 3334 6 , , , cord-028721-x6f26ahr 3334 7 12 12 CD cord-028721-x6f26ahr 3334 8 - - SYM cord-028721-x6f26ahr 3334 9 152 152 CD cord-028721-x6f26ahr 3334 10 ) ) -RRB- cord-028721-x6f26ahr 3334 11 . . . cord-028721-x6f26ahr 3335 1 Spermatogenesis Spermatogenesis NNP cord-028721-x6f26ahr 3335 2 is be VBZ cord-028721-x6f26ahr 3335 3 defi defi NNP cord-028721-x6f26ahr 3335 4 cient cient NNP cord-028721-x6f26ahr 3335 5 . . . cord-028721-x6f26ahr 3336 1 1405 1405 CD cord-028721-x6f26ahr 3336 2 Enzyme enzyme NN cord-028721-x6f26ahr 3336 3 replacement replacement NN cord-028721-x6f26ahr 3336 4 therapy therapy NN cord-028721-x6f26ahr 3336 5 with with IN cord-028721-x6f26ahr 3336 6 recombinant recombinant JJ cord-028721-x6f26ahr 3336 7 human human NN cord-028721-x6f26ahr 3336 8 α α NN cord-028721-x6f26ahr 3336 9 - - HYPH cord-028721-x6f26ahr 3336 10 galactosidase galactosidase NN cord-028721-x6f26ahr 3336 11 eliminates eliminate VBZ cord-028721-x6f26ahr 3336 12 existing exist VBG cord-028721-x6f26ahr 3336 13 glycosphingolipid glycosphingolipid NN cord-028721-x6f26ahr 3336 14 deposits deposit NNS cord-028721-x6f26ahr 3336 15 and and CC cord-028721-x6f26ahr 3336 16 blocks block VBZ cord-028721-x6f26ahr 3336 17 new new JJ cord-028721-x6f26ahr 3336 18 ones one NNS cord-028721-x6f26ahr 3336 19 , , , cord-028721-x6f26ahr 3336 20 and and CC cord-028721-x6f26ahr 3336 21 is be VBZ cord-028721-x6f26ahr 3336 22 thus thus RB cord-028721-x6f26ahr 3336 23 recommended recommend VBN cord-028721-x6f26ahr 3336 24 for for IN cord-028721-x6f26ahr 3336 25 implementation implementation NN cord-028721-x6f26ahr 3336 26 as as RB cord-028721-x6f26ahr 3336 27 soon soon RB cord-028721-x6f26ahr 3336 28 as as IN cord-028721-x6f26ahr 3336 29 possible possible JJ cord-028721-x6f26ahr 3336 30 after after IN cord-028721-x6f26ahr 3336 31 diagnosis diagnosis NN cord-028721-x6f26ahr 3336 32 . . . cord-028721-x6f26ahr 3337 1 [ [ -LRB- cord-028721-x6f26ahr 3337 2 1406 1406 CD cord-028721-x6f26ahr 3337 3 ] ] -RRB- cord-028721-x6f26ahr 3337 4 [ [ -LRB- cord-028721-x6f26ahr 3337 5 1407 1407 CD cord-028721-x6f26ahr 3337 6 ] ] -RRB- cord-028721-x6f26ahr 3338 1 [ [ -LRB- cord-028721-x6f26ahr 3338 2 1408 1408 CD cord-028721-x6f26ahr 3338 3 ] ] -RRB- cord-028721-x6f26ahr 3339 1 Adrenoleukodystrophy Adrenoleukodystrophy NNP cord-028721-x6f26ahr 3339 2 ( ( -LRB- cord-028721-x6f26ahr 3339 3 adrenal adrenal JJ cord-028721-x6f26ahr 3339 4 testicular testicular NN cord-028721-x6f26ahr 3339 5 myeloneuropathy myeloneuropathy NNP cord-028721-x6f26ahr 3339 6 ) ) -RRB- cord-028721-x6f26ahr 3340 1 This this DT cord-028721-x6f26ahr 3340 2 disorder disorder NN cord-028721-x6f26ahr 3340 3 is be VBZ cord-028721-x6f26ahr 3340 4 caused cause VBN cord-028721-x6f26ahr 3340 5 by by IN cord-028721-x6f26ahr 3340 6 mutation mutation NN cord-028721-x6f26ahr 3340 7 in in IN cord-028721-x6f26ahr 3340 8 the the DT cord-028721-x6f26ahr 3340 9 adrenoleukodystrophy adrenoleukodystrophy NN cord-028721-x6f26ahr 3340 10 gene gene NN cord-028721-x6f26ahr 3340 11 on on IN cord-028721-x6f26ahr 3340 12 Xq28 Xq28 NNP cord-028721-x6f26ahr 3340 13 . . . cord-028721-x6f26ahr 3341 1 1409 1409 CD cord-028721-x6f26ahr 3342 1 Mutation mutation NN cord-028721-x6f26ahr 3342 2 at at IN cord-028721-x6f26ahr 3342 3 this this DT cord-028721-x6f26ahr 3342 4 site site NN cord-028721-x6f26ahr 3342 5 produces produce VBZ cord-028721-x6f26ahr 3342 6 three three CD cord-028721-x6f26ahr 3342 7 peroxisomal peroxisomal JJ cord-028721-x6f26ahr 3342 8 diseases disease NNS cord-028721-x6f26ahr 3342 9 : : : cord-028721-x6f26ahr 3342 10 adrenoleukodystrophy adrenoleukodystrophy NN cord-028721-x6f26ahr 3342 11 , , , cord-028721-x6f26ahr 3342 12 adrenomyeloneuropathy adrenomyeloneuropathy NNP cord-028721-x6f26ahr 3342 13 , , , cord-028721-x6f26ahr 3342 14 and and CC cord-028721-x6f26ahr 3342 15 Addison Addison NNP cord-028721-x6f26ahr 3342 16 's 's POS cord-028721-x6f26ahr 3342 17 disease disease NN cord-028721-x6f26ahr 3342 18 . . . cord-028721-x6f26ahr 3343 1 Adrenoleukodystrophy Adrenoleukodystrophy NNP cord-028721-x6f26ahr 3343 2 is be VBZ cord-028721-x6f26ahr 3343 3 characterized characterize VBN cord-028721-x6f26ahr 3343 4 by by IN cord-028721-x6f26ahr 3343 5 progressive progressive JJ cord-028721-x6f26ahr 3343 6 demyelinization demyelinization NN cord-028721-x6f26ahr 3343 7 of of IN cord-028721-x6f26ahr 3343 8 the the DT cord-028721-x6f26ahr 3343 9 central central JJ cord-028721-x6f26ahr 3343 10 nervous nervous JJ cord-028721-x6f26ahr 3343 11 system system NN cord-028721-x6f26ahr 3343 12 , , , cord-028721-x6f26ahr 3343 13 usually usually RB cord-028721-x6f26ahr 3343 14 in in IN cord-028721-x6f26ahr 3343 15 children child NNS cord-028721-x6f26ahr 3343 16 and and CC cord-028721-x6f26ahr 3343 17 young young JJ cord-028721-x6f26ahr 3343 18 adults adult NNS cord-028721-x6f26ahr 3343 19 , , , cord-028721-x6f26ahr 3343 20 often often RB cord-028721-x6f26ahr 3343 21 with with IN cord-028721-x6f26ahr 3343 22 adrenal adrenal JJ cord-028721-x6f26ahr 3343 23 insuffi insuffi NNP cord-028721-x6f26ahr 3343 24 ciency ciency NNP cord-028721-x6f26ahr 3343 25 and and CC cord-028721-x6f26ahr 3343 26 testicular testicular JJ cord-028721-x6f26ahr 3343 27 failure failure NN cord-028721-x6f26ahr 3343 28 . . . cord-028721-x6f26ahr 3344 1 Peroxisomal Peroxisomal NNP cord-028721-x6f26ahr 3344 2 β β NN cord-028721-x6f26ahr 3344 3 - - HYPH cord-028721-x6f26ahr 3344 4 oxidation oxidation NN cord-028721-x6f26ahr 3344 5 is be VBZ cord-028721-x6f26ahr 3344 6 defi defi NNP cord-028721-x6f26ahr 3344 7 cient cient NNP cord-028721-x6f26ahr 3344 8 and and CC cord-028721-x6f26ahr 3344 9 , , , cord-028721-x6f26ahr 3344 10 as as IN cord-028721-x6f26ahr 3344 11 a a DT cord-028721-x6f26ahr 3344 12 result result NN cord-028721-x6f26ahr 3344 13 , , , cord-028721-x6f26ahr 3344 14 very very RB cord-028721-x6f26ahr 3344 15 long long JJ cord-028721-x6f26ahr 3344 16 - - HYPH cord-028721-x6f26ahr 3344 17 chain chain NN cord-028721-x6f26ahr 3344 18 fatty fatty JJ cord-028721-x6f26ahr 3344 19 acids acid NNS cord-028721-x6f26ahr 3344 20 accumulate accumulate VBP cord-028721-x6f26ahr 3344 21 inside inside IN cord-028721-x6f26ahr 3344 22 peroxisomes peroxisome NNS cord-028721-x6f26ahr 3344 23 in in IN cord-028721-x6f26ahr 3344 24 many many JJ cord-028721-x6f26ahr 3344 25 tissues tissue NNS cord-028721-x6f26ahr 3344 26 , , , cord-028721-x6f26ahr 3344 27 causing cause VBG cord-028721-x6f26ahr 3344 28 the the DT cord-028721-x6f26ahr 3344 29 signs sign NNS cord-028721-x6f26ahr 3344 30 and and CC cord-028721-x6f26ahr 3344 31 symptoms symptom NNS cord-028721-x6f26ahr 3344 32 of of IN cord-028721-x6f26ahr 3344 33 the the DT cord-028721-x6f26ahr 3344 34 disease disease NN cord-028721-x6f26ahr 3344 35 . . . cord-028721-x6f26ahr 3345 1 1410 1410 CD cord-028721-x6f26ahr 3345 2 , , , cord-028721-x6f26ahr 3345 3 1411 1411 CD cord-028721-x6f26ahr 3346 1 Adrenomyeloneuropathy Adrenomyeloneuropathy NNP cord-028721-x6f26ahr 3346 2 begins begin VBZ cord-028721-x6f26ahr 3346 3 at at IN cord-028721-x6f26ahr 3346 4 a a DT cord-028721-x6f26ahr 3346 5 later later JJ cord-028721-x6f26ahr 3346 6 age age NN cord-028721-x6f26ahr 3346 7 ( ( -LRB- cord-028721-x6f26ahr 3346 8 about about RB cord-028721-x6f26ahr 3346 9 30 30 CD cord-028721-x6f26ahr 3346 10 years year NNS cord-028721-x6f26ahr 3346 11 ) ) -RRB- cord-028721-x6f26ahr 3346 12 with with IN cord-028721-x6f26ahr 3346 13 progressive progressive JJ cord-028721-x6f26ahr 3346 14 paraparesis paraparesis NN cord-028721-x6f26ahr 3346 15 , , , cord-028721-x6f26ahr 3346 16 peripheral peripheral JJ cord-028721-x6f26ahr 3346 17 neuropathy neuropathy NN cord-028721-x6f26ahr 3346 18 , , , cord-028721-x6f26ahr 3346 19 and and CC cord-028721-x6f26ahr 3346 20 adrenal adrenal JJ cord-028721-x6f26ahr 3346 21 cortical cortical JJ cord-028721-x6f26ahr 3346 22 failure failure NN cord-028721-x6f26ahr 3346 23 . . . cord-028721-x6f26ahr 3347 1 Males male NNS cord-028721-x6f26ahr 3347 2 usually usually RB cord-028721-x6f26ahr 3347 3 have have VBP cord-028721-x6f26ahr 3347 4 gonadal gonadal JJ cord-028721-x6f26ahr 3347 5 dysfunction dysfunction NN cord-028721-x6f26ahr 3347 6 with with IN cord-028721-x6f26ahr 3347 7 oligozoospermia oligozoospermia NNP cord-028721-x6f26ahr 3347 8 or or CC cord-028721-x6f26ahr 3347 9 azoospermia azoospermia NN cord-028721-x6f26ahr 3347 10 and and CC cord-028721-x6f26ahr 3347 11 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 3347 12 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 3347 13 . . . cord-028721-x6f26ahr 3348 1 1412 1412 CD cord-028721-x6f26ahr 3348 2 Testicular testicular JJ cord-028721-x6f26ahr 3348 3 atrophy atrophy NN cord-028721-x6f26ahr 3348 4 develops develop VBZ cord-028721-x6f26ahr 3348 5 slowly slowly RB cord-028721-x6f26ahr 3348 6 , , , cord-028721-x6f26ahr 3348 7 the the DT cord-028721-x6f26ahr 3348 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 3348 9 epithelium epithelium NN cord-028721-x6f26ahr 3348 10 disappear disappear VBP cord-028721-x6f26ahr 3348 11 , , , cord-028721-x6f26ahr 3348 12 and and CC cord-028721-x6f26ahr 3348 13 Leydig leydig NN cord-028721-x6f26ahr 3348 14 cells cell NNS cord-028721-x6f26ahr 3348 15 contain contain VBP cord-028721-x6f26ahr 3348 16 characteristic characteristic JJ cord-028721-x6f26ahr 3348 17 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 3348 18 lamellar lamellar JJ cord-028721-x6f26ahr 3348 19 inclusions inclusion NNS cord-028721-x6f26ahr 3348 20 , , , cord-028721-x6f26ahr 3348 21 with with IN cord-028721-x6f26ahr 3348 22 similar similar JJ cord-028721-x6f26ahr 3348 23 inclusions inclusion NNS cord-028721-x6f26ahr 3348 24 in in IN cord-028721-x6f26ahr 3348 25 adrenal adrenal JJ cord-028721-x6f26ahr 3348 26 cortical cortical JJ cord-028721-x6f26ahr 3348 27 cells cell NNS cord-028721-x6f26ahr 3348 28 and and CC cord-028721-x6f26ahr 3348 29 cerebral cerebral JJ cord-028721-x6f26ahr 3348 30 cells cell NNS cord-028721-x6f26ahr 3348 31 . . . cord-028721-x6f26ahr 3349 1 1413 1413 CD cord-028721-x6f26ahr 3349 2 _SP cord-028721-x6f26ahr 3350 1 Wolman Wolman NNP cord-028721-x6f26ahr 3350 2 's 's POS cord-028721-x6f26ahr 3350 3 disease disease NN cord-028721-x6f26ahr 3350 4 is be VBZ cord-028721-x6f26ahr 3350 5 a a DT cord-028721-x6f26ahr 3350 6 rare rare JJ cord-028721-x6f26ahr 3350 7 inherited inherit VBN cord-028721-x6f26ahr 3350 8 lysosomal lysosomal JJ cord-028721-x6f26ahr 3350 9 disease disease NN cord-028721-x6f26ahr 3350 10 characterized characterize VBN cord-028721-x6f26ahr 3350 11 by by IN cord-028721-x6f26ahr 3350 12 a a DT cord-028721-x6f26ahr 3350 13 defi defi NNP cord-028721-x6f26ahr 3350 14 cit cit NNP cord-028721-x6f26ahr 3350 15 in in IN cord-028721-x6f26ahr 3350 16 acid acid JJ cord-028721-x6f26ahr 3350 17 lipase lipase NNP cord-028721-x6f26ahr 3350 18 / / SYM cord-028721-x6f26ahr 3350 19 cholesteryl cholesteryl NNP cord-028721-x6f26ahr 3350 20 ester ester NNP cord-028721-x6f26ahr 3350 21 hydrolase hydrolase NNP cord-028721-x6f26ahr 3350 22 . . . cord-028721-x6f26ahr 3351 1 The the DT cord-028721-x6f26ahr 3351 2 genetic genetic JJ cord-028721-x6f26ahr 3351 3 mutation mutation NN cord-028721-x6f26ahr 3351 4 has have VBZ cord-028721-x6f26ahr 3351 5 been be VBN cord-028721-x6f26ahr 3351 6 mapped map VBN cord-028721-x6f26ahr 3351 7 to to IN cord-028721-x6f26ahr 3351 8 10q23.2-q23.3 10q23.2-q23.3 CD cord-028721-x6f26ahr 3351 9 . . . cord-028721-x6f26ahr 3352 1 1414 1414 CD cord-028721-x6f26ahr 3353 1 Complete complete JJ cord-028721-x6f26ahr 3353 2 enzymatic enzymatic JJ cord-028721-x6f26ahr 3353 3 defi defi NN cord-028721-x6f26ahr 3353 4 ciency ciency NN cord-028721-x6f26ahr 3354 1 ( ( -LRB- cord-028721-x6f26ahr 3354 2 Wolman Wolman NNP cord-028721-x6f26ahr 3354 3 's 's POS cord-028721-x6f26ahr 3354 4 disease disease NN cord-028721-x6f26ahr 3354 5 ) ) -RRB- cord-028721-x6f26ahr 3354 6 causes cause VBZ cord-028721-x6f26ahr 3354 7 death death NN cord-028721-x6f26ahr 3354 8 in in IN cord-028721-x6f26ahr 3354 9 infancy infancy NN cord-028721-x6f26ahr 3354 10 as as IN cord-028721-x6f26ahr 3354 11 a a DT cord-028721-x6f26ahr 3354 12 result result NN cord-028721-x6f26ahr 3354 13 of of IN cord-028721-x6f26ahr 3354 14 the the DT cord-028721-x6f26ahr 3354 15 accumulation accumulation NN cord-028721-x6f26ahr 3354 16 of of IN cord-028721-x6f26ahr 3354 17 cholesterol cholesterol NN cord-028721-x6f26ahr 3354 18 esters ester NNS cord-028721-x6f26ahr 3354 19 and and CC cord-028721-x6f26ahr 3354 20 triglycerides triglyceride NNS cord-028721-x6f26ahr 3354 21 in in IN cord-028721-x6f26ahr 3354 22 numerous numerous JJ cord-028721-x6f26ahr 3354 23 organs organ NNS cord-028721-x6f26ahr 3354 24 such such JJ cord-028721-x6f26ahr 3354 25 as as IN cord-028721-x6f26ahr 3354 26 the the DT cord-028721-x6f26ahr 3354 27 liver liver NN cord-028721-x6f26ahr 3354 28 , , , cord-028721-x6f26ahr 3354 29 adrenal adrenal JJ cord-028721-x6f26ahr 3354 30 cortex cortex NN cord-028721-x6f26ahr 3354 31 , , , cord-028721-x6f26ahr 3354 32 and and CC cord-028721-x6f26ahr 3354 33 intestines intestine NNS cord-028721-x6f26ahr 3354 34 . . . cord-028721-x6f26ahr 3355 1 1415 1415 CD cord-028721-x6f26ahr 3356 1 Partial partial JJ cord-028721-x6f26ahr 3356 2 defi defi NN cord-028721-x6f26ahr 3356 3 ciency ciency NNP cord-028721-x6f26ahr 3356 4 is be VBZ cord-028721-x6f26ahr 3356 5 known know VBN cord-028721-x6f26ahr 3356 6 as as IN cord-028721-x6f26ahr 3356 7 cholesteryl cholesteryl NNP cord-028721-x6f26ahr 3356 8 ester ester NNP cord-028721-x6f26ahr 3356 9 storage storage NN cord-028721-x6f26ahr 3356 10 disease disease NN cord-028721-x6f26ahr 3356 11 , , , cord-028721-x6f26ahr 3356 12 and and CC cord-028721-x6f26ahr 3356 13 the the DT cord-028721-x6f26ahr 3356 14 testis testis NN cord-028721-x6f26ahr 3356 15 accumulates accumulate VBZ cord-028721-x6f26ahr 3356 16 triglycerides triglyceride NNS cord-028721-x6f26ahr 3356 17 and and CC cord-028721-x6f26ahr 3356 18 cholesterol cholesterol NN cord-028721-x6f26ahr 3356 19 in in IN cord-028721-x6f26ahr 3356 20 Leydig Leydig NNP cord-028721-x6f26ahr 3356 21 cells cell NNS cord-028721-x6f26ahr 3356 22 and and CC cord-028721-x6f26ahr 3356 23 , , , cord-028721-x6f26ahr 3356 24 to to IN cord-028721-x6f26ahr 3356 25 a a DT cord-028721-x6f26ahr 3356 26 lesser less JJR cord-028721-x6f26ahr 3356 27 degree degree NN cord-028721-x6f26ahr 3356 28 , , , cord-028721-x6f26ahr 3356 29 in in IN cord-028721-x6f26ahr 3356 30 interstitial interstitial JJ cord-028721-x6f26ahr 3356 31 macrophages macrophage NNS cord-028721-x6f26ahr 3356 32 . . . cord-028721-x6f26ahr 3357 1 Delayed delayed JJ cord-028721-x6f26ahr 3357 2 disruption disruption NN cord-028721-x6f26ahr 3357 3 of of IN cord-028721-x6f26ahr 3357 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3357 5 by by IN cord-028721-x6f26ahr 3357 6 this this DT cord-028721-x6f26ahr 3357 7 storage storage NN cord-028721-x6f26ahr 3357 8 disease disease NN cord-028721-x6f26ahr 3357 9 probably probably RB cord-028721-x6f26ahr 3357 10 accounts account VBZ cord-028721-x6f26ahr 3357 11 for for IN cord-028721-x6f26ahr 3357 12 the the DT cord-028721-x6f26ahr 3357 13 frequent frequent JJ cord-028721-x6f26ahr 3357 14 lack lack NN cord-028721-x6f26ahr 3357 15 of of IN cord-028721-x6f26ahr 3357 16 fertility fertility NN cord-028721-x6f26ahr 3357 17 problems problem NNS cord-028721-x6f26ahr 3357 18 in in IN cord-028721-x6f26ahr 3357 19 men man NNS cord-028721-x6f26ahr 3357 20 with with IN cord-028721-x6f26ahr 3357 21 this this DT cord-028721-x6f26ahr 3357 22 disease disease NN cord-028721-x6f26ahr 3357 23 . . . cord-028721-x6f26ahr 3358 1 1416 1416 CD cord-028721-x6f26ahr 3359 1 Early early JJ cord-028721-x6f26ahr 3359 2 treatment treatment NN cord-028721-x6f26ahr 3359 3 of of IN cord-028721-x6f26ahr 3359 4 children child NNS cord-028721-x6f26ahr 3359 5 with with IN cord-028721-x6f26ahr 3359 6 Wolman Wolman NNP cord-028721-x6f26ahr 3359 7 's 's POS cord-028721-x6f26ahr 3359 8 disease disease NN cord-028721-x6f26ahr 3359 9 by by IN cord-028721-x6f26ahr 3359 10 transplantation transplantation NN cord-028721-x6f26ahr 3359 11 of of IN cord-028721-x6f26ahr 3359 12 umbilical umbilical JJ cord-028721-x6f26ahr 3359 13 cord cord NN cord-028721-x6f26ahr 3359 14 blood blood NN cord-028721-x6f26ahr 3359 15 - - HYPH cord-028721-x6f26ahr 3359 16 derived derive VBN cord-028721-x6f26ahr 3359 17 stem stem NN cord-028721-x6f26ahr 3359 18 cells cell NNS cord-028721-x6f26ahr 3359 19 may may MD cord-028721-x6f26ahr 3359 20 successfully successfully RB cord-028721-x6f26ahr 3359 21 restore restore VB cord-028721-x6f26ahr 3359 22 acid acid NN cord-028721-x6f26ahr 3359 23 lipase lipase NN cord-028721-x6f26ahr 3359 24 level level NN cord-028721-x6f26ahr 3359 25 in in IN cord-028721-x6f26ahr 3359 26 some some DT cord-028721-x6f26ahr 3359 27 . . . cord-028721-x6f26ahr 3360 1 1417 1417 CD cord-028721-x6f26ahr 3360 2 _SP cord-028721-x6f26ahr 3361 1 Cystinosis Cystinosis NNP cord-028721-x6f26ahr 3361 2 is be VBZ cord-028721-x6f26ahr 3361 3 an an DT cord-028721-x6f26ahr 3361 4 autosomal autosomal JJ cord-028721-x6f26ahr 3361 5 recessive recessive JJ cord-028721-x6f26ahr 3361 6 metabolopathy metabolopathy NN cord-028721-x6f26ahr 3361 7 characterized characterize VBN cord-028721-x6f26ahr 3361 8 by by IN cord-028721-x6f26ahr 3361 9 alterations alteration NNS cord-028721-x6f26ahr 3361 10 in in IN cord-028721-x6f26ahr 3361 11 cystine cystine NN cord-028721-x6f26ahr 3361 12 transport transport NN cord-028721-x6f26ahr 3361 13 from from IN cord-028721-x6f26ahr 3361 14 the the DT cord-028721-x6f26ahr 3361 15 lysosomes lysosome NNS cord-028721-x6f26ahr 3361 16 to to IN cord-028721-x6f26ahr 3361 17 the the DT cord-028721-x6f26ahr 3361 18 cytosol cytosol NN cord-028721-x6f26ahr 3361 19 that that WDT cord-028721-x6f26ahr 3361 20 results result VBZ cord-028721-x6f26ahr 3361 21 in in IN cord-028721-x6f26ahr 3361 22 intralysosomal intralysosomal JJ cord-028721-x6f26ahr 3361 23 accumulation accumulation NN cord-028721-x6f26ahr 3361 24 of of IN cord-028721-x6f26ahr 3361 25 cystine cystine NN cord-028721-x6f26ahr 3361 26 . . . cord-028721-x6f26ahr 3362 1 There there EX cord-028721-x6f26ahr 3362 2 are be VBP cord-028721-x6f26ahr 3362 3 several several JJ cord-028721-x6f26ahr 3362 4 genes gene NNS cord-028721-x6f26ahr 3362 5 responsible responsible JJ cord-028721-x6f26ahr 3362 6 , , , cord-028721-x6f26ahr 3362 7 all all DT cord-028721-x6f26ahr 3362 8 on on IN cord-028721-x6f26ahr 3362 9 chromosome chromosome NN cord-028721-x6f26ahr 3362 10 17p13 17p13 CD cord-028721-x6f26ahr 3362 11 . . . cord-028721-x6f26ahr 3363 1 Cystine cystine JJ cord-028721-x6f26ahr 3363 2 storage storage NN cord-028721-x6f26ahr 3363 3 occurs occur VBZ cord-028721-x6f26ahr 3363 4 in in IN cord-028721-x6f26ahr 3363 5 all all DT cord-028721-x6f26ahr 3363 6 body body NN cord-028721-x6f26ahr 3363 7 tissues tissue NNS cord-028721-x6f26ahr 3363 8 . . . cord-028721-x6f26ahr 3364 1 Deposits deposit NNS cord-028721-x6f26ahr 3364 2 in in IN cord-028721-x6f26ahr 3364 3 the the DT cord-028721-x6f26ahr 3364 4 renal renal JJ cord-028721-x6f26ahr 3364 5 parenchyma parenchyma NNS cord-028721-x6f26ahr 3364 6 cause cause VBP cord-028721-x6f26ahr 3364 7 the the DT cord-028721-x6f26ahr 3364 8 main main JJ cord-028721-x6f26ahr 3364 9 complication complication NN cord-028721-x6f26ahr 3364 10 of of IN cord-028721-x6f26ahr 3364 11 cystinosis cystinosis NN cord-028721-x6f26ahr 3364 12 , , , cord-028721-x6f26ahr 3364 13 namely namely RB cord-028721-x6f26ahr 3364 14 renal renal JJ cord-028721-x6f26ahr 3364 15 insuffi insuffi NNP cord-028721-x6f26ahr 3364 16 ciency ciency NNP cord-028721-x6f26ahr 3364 17 ( ( -LRB- cord-028721-x6f26ahr 3364 18 nephropathic nephropathic NNP cord-028721-x6f26ahr 3364 19 cystinosis cystinosis NNP cord-028721-x6f26ahr 3364 20 ) ) -RRB- cord-028721-x6f26ahr 3364 21 . . . cord-028721-x6f26ahr 3365 1 Patients patient NNS cord-028721-x6f26ahr 3365 2 also also RB cord-028721-x6f26ahr 3365 3 develop develop VBP cord-028721-x6f26ahr 3365 4 hypergonadotropic hypergonadotropic JJ cord-028721-x6f26ahr 3365 5 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3365 6 . . . cord-028721-x6f26ahr 3366 1 Testicular testicular JJ cord-028721-x6f26ahr 3366 2 involvement involvement NN cord-028721-x6f26ahr 3366 3 may may MD cord-028721-x6f26ahr 3366 4 be be VB cord-028721-x6f26ahr 3366 5 massive massive JJ cord-028721-x6f26ahr 3366 6 , , , cord-028721-x6f26ahr 3366 7 with with IN cord-028721-x6f26ahr 3366 8 interstitial interstitial JJ cord-028721-x6f26ahr 3366 9 macrophages macrophage NNS cord-028721-x6f26ahr 3366 10 fi fi NNP cord-028721-x6f26ahr 3366 11 lled lle VBN cord-028721-x6f26ahr 3366 12 with with IN cord-028721-x6f26ahr 3366 13 cystine cystine NN cord-028721-x6f26ahr 3366 14 crystals crystal NNS cord-028721-x6f26ahr 3366 15 that that WDT cord-028721-x6f26ahr 3366 16 are be VBP cord-028721-x6f26ahr 3366 17 visible visible JJ cord-028721-x6f26ahr 3366 18 by by IN cord-028721-x6f26ahr 3366 19 polarized polarized JJ cord-028721-x6f26ahr 3366 20 light light NN cord-028721-x6f26ahr 3366 21 . . . cord-028721-x6f26ahr 3367 1 1418 1418 CD cord-028721-x6f26ahr 3367 2 _SP cord-028721-x6f26ahr 3368 1 Niemann Niemann NNP cord-028721-x6f26ahr 3368 2 - - HYPH cord-028721-x6f26ahr 3368 3 Pick Pick NNP cord-028721-x6f26ahr 3368 4 disease disease NN cord-028721-x6f26ahr 3368 5 consists consist VBZ cord-028721-x6f26ahr 3368 6 of of IN cord-028721-x6f26ahr 3368 7 a a DT cord-028721-x6f26ahr 3368 8 heterogeneous heterogeneous JJ cord-028721-x6f26ahr 3368 9 group group NN cord-028721-x6f26ahr 3368 10 of of IN cord-028721-x6f26ahr 3368 11 inherited inherit VBN cord-028721-x6f26ahr 3368 12 recessive recessive JJ cord-028721-x6f26ahr 3368 13 autosomal autosomal JJ cord-028721-x6f26ahr 3368 14 diseases disease NNS cord-028721-x6f26ahr 3368 15 characterized characterize VBN cord-028721-x6f26ahr 3368 16 by by IN cord-028721-x6f26ahr 3368 17 deposition deposition NN cord-028721-x6f26ahr 3368 18 of of IN cord-028721-x6f26ahr 3368 19 lipids lipid NNS cord-028721-x6f26ahr 3368 20 in in IN cord-028721-x6f26ahr 3368 21 macrophages macrophage NNS cord-028721-x6f26ahr 3368 22 and and CC cord-028721-x6f26ahr 3368 23 other other JJ cord-028721-x6f26ahr 3368 24 tissues tissue NNS cord-028721-x6f26ahr 3368 25 . . . cord-028721-x6f26ahr 3369 1 There there EX cord-028721-x6f26ahr 3369 2 are be VBP cord-028721-x6f26ahr 3369 3 four four CD cord-028721-x6f26ahr 3369 4 reported report VBN cord-028721-x6f26ahr 3369 5 types type NNS cord-028721-x6f26ahr 3369 6 ( ( -LRB- cord-028721-x6f26ahr 3369 7 A A NNP cord-028721-x6f26ahr 3369 8 , , , cord-028721-x6f26ahr 3369 9 B B NNP cord-028721-x6f26ahr 3369 10 , , , cord-028721-x6f26ahr 3369 11 C C NNP cord-028721-x6f26ahr 3369 12 , , , cord-028721-x6f26ahr 3369 13 D D NNP cord-028721-x6f26ahr 3369 14 ) ) -RRB- cord-028721-x6f26ahr 3369 15 . . . cord-028721-x6f26ahr 3370 1 The the DT cord-028721-x6f26ahr 3370 2 most most RBS cord-028721-x6f26ahr 3370 3 common common JJ cord-028721-x6f26ahr 3370 4 , , , cord-028721-x6f26ahr 3370 5 type type NN cord-028721-x6f26ahr 3370 6 A a NN cord-028721-x6f26ahr 3370 7 , , , cord-028721-x6f26ahr 3370 8 results result NNS cord-028721-x6f26ahr 3370 9 from from IN cord-028721-x6f26ahr 3370 10 excessive excessive JJ cord-028721-x6f26ahr 3370 11 storage storage NN cord-028721-x6f26ahr 3370 12 of of IN cord-028721-x6f26ahr 3370 13 sphingomyelin sphingomyelin NN cord-028721-x6f26ahr 3370 14 owing owe VBG cord-028721-x6f26ahr 3370 15 to to IN cord-028721-x6f26ahr 3370 16 a a DT cord-028721-x6f26ahr 3370 17 mutation mutation NN cord-028721-x6f26ahr 3370 18 in in IN cord-028721-x6f26ahr 3370 19 the the DT cord-028721-x6f26ahr 3370 20 acid acid NN cord-028721-x6f26ahr 3370 21 sphingomyelin sphingomyelin NN cord-028721-x6f26ahr 3370 22 gene gene NN cord-028721-x6f26ahr 3370 23 that that WDT cord-028721-x6f26ahr 3370 24 encodes encode VBZ cord-028721-x6f26ahr 3370 25 a a DT cord-028721-x6f26ahr 3370 26 lysosomal lysosomal JJ cord-028721-x6f26ahr 3370 27 hydrolase hydrolase NN cord-028721-x6f26ahr 3370 28 , , , cord-028721-x6f26ahr 3370 29 located locate VBN cord-028721-x6f26ahr 3370 30 on on IN cord-028721-x6f26ahr 3370 31 11p15.1 11p15.1 CD cord-028721-x6f26ahr 3370 32 - - SYM cord-028721-x6f26ahr 3370 33 4 4 CD cord-028721-x6f26ahr 3370 34 region region NN cord-028721-x6f26ahr 3370 35 . . . cord-028721-x6f26ahr 3371 1 1419 1419 CD cord-028721-x6f26ahr 3371 2 Interstitial interstitial JJ cord-028721-x6f26ahr 3371 3 macrophages macrophage NNS cord-028721-x6f26ahr 3371 4 in in IN cord-028721-x6f26ahr 3371 5 the the DT cord-028721-x6f26ahr 3371 6 testes testis NNS cord-028721-x6f26ahr 3371 7 have have VBP cord-028721-x6f26ahr 3371 8 wide wide RB cord-028721-x6f26ahr 3371 9 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 3371 10 , , , cord-028721-x6f26ahr 3371 11 granular granular JJ cord-028721-x6f26ahr 3371 12 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3371 13 . . . cord-028721-x6f26ahr 3372 1 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 3372 2 studies study NNS cord-028721-x6f26ahr 3372 3 reveal reveal VBP cord-028721-x6f26ahr 3372 4 a a DT cord-028721-x6f26ahr 3372 5 large large JJ cord-028721-x6f26ahr 3372 6 number number NN cord-028721-x6f26ahr 3372 7 of of IN cord-028721-x6f26ahr 3372 8 lysosomes lysosome NNS cord-028721-x6f26ahr 3372 9 fi fi NNP cord-028721-x6f26ahr 3372 10 lled lle VBN cord-028721-x6f26ahr 3372 11 with with IN cord-028721-x6f26ahr 3372 12 laminate laminate NN cord-028721-x6f26ahr 3372 13 bodies body NNS cord-028721-x6f26ahr 3372 14 . . . cord-028721-x6f26ahr 3373 1 Physical physical JJ cord-028721-x6f26ahr 3373 2 and and CC cord-028721-x6f26ahr 3373 3 chemical chemical JJ cord-028721-x6f26ahr 3373 4 agents agent NNS cord-028721-x6f26ahr 3373 5 may may MD cord-028721-x6f26ahr 3373 6 impair impair VB cord-028721-x6f26ahr 3373 7 testicular testicular JJ cord-028721-x6f26ahr 3373 8 function function NN cord-028721-x6f26ahr 3373 9 by by IN cord-028721-x6f26ahr 3373 10 direct direct JJ cord-028721-x6f26ahr 3373 11 action action NN cord-028721-x6f26ahr 3373 12 on on IN cord-028721-x6f26ahr 3373 13 the the DT cord-028721-x6f26ahr 3373 14 pituitary pituitary NN cord-028721-x6f26ahr 3373 15 , , , cord-028721-x6f26ahr 3373 16 the the DT cord-028721-x6f26ahr 3373 17 testis testis NN cord-028721-x6f26ahr 3373 18 , , , cord-028721-x6f26ahr 3373 19 or or CC cord-028721-x6f26ahr 3373 20 the the DT cord-028721-x6f26ahr 3373 21 sperm sperm NN cord-028721-x6f26ahr 3373 22 excretory excretory JJ cord-028721-x6f26ahr 3373 23 ducts duct NNS cord-028721-x6f26ahr 3373 24 . . . cord-028721-x6f26ahr 3374 1 In in IN cord-028721-x6f26ahr 3374 2 the the DT cord-028721-x6f26ahr 3374 3 pituitary pituitary NN cord-028721-x6f26ahr 3374 4 , , , cord-028721-x6f26ahr 3374 5 damage damage NN cord-028721-x6f26ahr 3374 6 to to IN cord-028721-x6f26ahr 3374 7 gonadotropic gonadotropic NNP cord-028721-x6f26ahr 3374 8 cells cell NNS cord-028721-x6f26ahr 3374 9 may may MD cord-028721-x6f26ahr 3374 10 be be VB cord-028721-x6f26ahr 3374 11 caused cause VBN cord-028721-x6f26ahr 3374 12 by by IN cord-028721-x6f26ahr 3374 13 estrogen estrogen NN cord-028721-x6f26ahr 3374 14 . . . cord-028721-x6f26ahr 3375 1 In in IN cord-028721-x6f26ahr 3375 2 the the DT cord-028721-x6f26ahr 3375 3 testes testis NNS cord-028721-x6f26ahr 3375 4 , , , cord-028721-x6f26ahr 3375 5 gonadotoxic gonadotoxic JJ cord-028721-x6f26ahr 3375 6 agents agent NNS cord-028721-x6f26ahr 3375 7 may may MD cord-028721-x6f26ahr 3375 8 selectively selectively RB cord-028721-x6f26ahr 3375 9 impair impair VB cord-028721-x6f26ahr 3375 10 a a DT cord-028721-x6f26ahr 3375 11 select select JJ cord-028721-x6f26ahr 3375 12 cell cell NN cord-028721-x6f26ahr 3375 13 type type NN cord-028721-x6f26ahr 3375 14 , , , cord-028721-x6f26ahr 3375 15 but but CC cord-028721-x6f26ahr 3375 16 later later RBR cord-028721-x6f26ahr 3375 17 , , , cord-028721-x6f26ahr 3375 18 global global JJ cord-028721-x6f26ahr 3375 19 dysfunction dysfunction NN cord-028721-x6f26ahr 3375 20 occurs occur VBZ cord-028721-x6f26ahr 3375 21 . . . cord-028721-x6f26ahr 3376 1 For for IN cord-028721-x6f26ahr 3376 2 example example NN cord-028721-x6f26ahr 3376 3 , , , cord-028721-x6f26ahr 3376 4 there there EX cord-028721-x6f26ahr 3376 5 is be VBZ cord-028721-x6f26ahr 3376 6 direct direct JJ cord-028721-x6f26ahr 3376 7 toxicity toxicity NN cord-028721-x6f26ahr 3376 8 to to IN cord-028721-x6f26ahr 3376 9 Sertoli sertoli JJ cord-028721-x6f26ahr 3376 10 cells cell NNS cord-028721-x6f26ahr 3376 11 by by IN cord-028721-x6f26ahr 3376 12 phthalates phthalate NNS cord-028721-x6f26ahr 3376 13 used use VBN cord-028721-x6f26ahr 3376 14 as as IN cord-028721-x6f26ahr 3376 15 plasticizers plasticizer NNS cord-028721-x6f26ahr 3376 16 , , , cord-028721-x6f26ahr 3376 17 nitroaromatic nitroaromatic JJ cord-028721-x6f26ahr 3376 18 compounds compound NNS cord-028721-x6f26ahr 3376 19 intermediate intermediate JJ cord-028721-x6f26ahr 3376 20 in in IN cord-028721-x6f26ahr 3376 21 the the DT cord-028721-x6f26ahr 3376 22 production production NN cord-028721-x6f26ahr 3376 23 of of IN cord-028721-x6f26ahr 3376 24 dyes dye NNS cord-028721-x6f26ahr 3376 25 and and CC cord-028721-x6f26ahr 3376 26 explosives explosive NNS cord-028721-x6f26ahr 3376 27 , , , cord-028721-x6f26ahr 3376 28 and and CC cord-028721-x6f26ahr 3376 29 γ γ NN cord-028721-x6f26ahr 3376 30 - - HYPH cord-028721-x6f26ahr 3376 31 diketones diketone NNS cord-028721-x6f26ahr 3376 32 used use VBN cord-028721-x6f26ahr 3376 33 as as IN cord-028721-x6f26ahr 3376 34 solvents solvent NNS cord-028721-x6f26ahr 3376 35 . . . cord-028721-x6f26ahr 3377 1 Direct direct JJ cord-028721-x6f26ahr 3377 2 toxicity toxicity NN cord-028721-x6f26ahr 3377 3 on on IN cord-028721-x6f26ahr 3377 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3377 5 is be VBZ cord-028721-x6f26ahr 3377 6 seen see VBN cord-028721-x6f26ahr 3377 7 wtih wtih NN cord-028721-x6f26ahr 3377 8 ionizing ionize VBG cord-028721-x6f26ahr 3377 9 radiation radiation NN cord-028721-x6f26ahr 3377 10 . . . cord-028721-x6f26ahr 3378 1 Many many JJ cord-028721-x6f26ahr 3378 2 drugs drug NNS cord-028721-x6f26ahr 3378 3 that that WDT cord-028721-x6f26ahr 3378 4 impair impair VBP cord-028721-x6f26ahr 3378 5 epididymal epididymal JJ cord-028721-x6f26ahr 3378 6 fl fl NNP cord-028721-x6f26ahr 3378 7 uid uid NN cord-028721-x6f26ahr 3378 8 or or CC cord-028721-x6f26ahr 3378 9 spermatozoon spermatozoon NN cord-028721-x6f26ahr 3378 10 transport transport NN cord-028721-x6f26ahr 3378 11 damage damage NN cord-028721-x6f26ahr 3378 12 sperm sperm NN cord-028721-x6f26ahr 3378 13 excretory excretory JJ cord-028721-x6f26ahr 3378 14 ducts duct NNS cord-028721-x6f26ahr 3378 15 , , , cord-028721-x6f26ahr 3378 16 with with IN cord-028721-x6f26ahr 3378 17 subsequent subsequent JJ cord-028721-x6f26ahr 3378 18 loss loss NN cord-028721-x6f26ahr 3378 19 of of IN cord-028721-x6f26ahr 3378 20 fertility fertility NN cord-028721-x6f26ahr 3378 21 . . . cord-028721-x6f26ahr 3379 1 1420 1420 CD cord-028721-x6f26ahr 3380 1 The the DT cord-028721-x6f26ahr 3380 2 relationship relationship NN cord-028721-x6f26ahr 3380 3 between between IN cord-028721-x6f26ahr 3380 4 infertility infertility NN cord-028721-x6f26ahr 3380 5 or or CC cord-028721-x6f26ahr 3380 6 subfertility subfertility NN cord-028721-x6f26ahr 3380 7 and and CC cord-028721-x6f26ahr 3380 8 certain certain JJ cord-028721-x6f26ahr 3380 9 professions profession NNS cord-028721-x6f26ahr 3380 10 or or CC cord-028721-x6f26ahr 3380 11 exposures exposure NNS cord-028721-x6f26ahr 3380 12 to to IN cord-028721-x6f26ahr 3380 13 environmental environmental JJ cord-028721-x6f26ahr 3380 14 agents agent NNS cord-028721-x6f26ahr 3380 15 is be VBZ cord-028721-x6f26ahr 3380 16 well well RB cord-028721-x6f26ahr 3380 17 known known JJ cord-028721-x6f26ahr 3380 18 . . . cord-028721-x6f26ahr 3381 1 1421 1421 CD cord-028721-x6f26ahr 3381 2 Adverse adverse JJ cord-028721-x6f26ahr 3381 3 effects effect NNS cord-028721-x6f26ahr 3381 4 of of IN cord-028721-x6f26ahr 3381 5 the the DT cord-028721-x6f26ahr 3381 6 following follow VBG cord-028721-x6f26ahr 3381 7 agents agent NNS cord-028721-x6f26ahr 3381 8 on on IN cord-028721-x6f26ahr 3381 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3381 10 has have VBZ cord-028721-x6f26ahr 3381 11 been be VBN cord-028721-x6f26ahr 3381 12 demonstrated demonstrate VBN cord-028721-x6f26ahr 3381 13 : : : cord-028721-x6f26ahr 3381 14 organic organic JJ cord-028721-x6f26ahr 3381 15 solvents solvent NNS cord-028721-x6f26ahr 3381 16 such such JJ cord-028721-x6f26ahr 3381 17 as as IN cord-028721-x6f26ahr 3381 18 chlorinated chlorinated JJ cord-028721-x6f26ahr 3381 19 solvents solvent NNS cord-028721-x6f26ahr 3381 20 , , , cord-028721-x6f26ahr 3381 21 aromatic aromatic JJ cord-028721-x6f26ahr 3381 22 solvents solvent NNS cord-028721-x6f26ahr 3381 23 and and CC cord-028721-x6f26ahr 3381 24 varnishes varnish NNS cord-028721-x6f26ahr 3381 25 , , , cord-028721-x6f26ahr 3381 26 degreasers degreaser NNS cord-028721-x6f26ahr 3381 27 , , , cord-028721-x6f26ahr 3381 28 thinners thinner NNS cord-028721-x6f26ahr 3381 29 , , , cord-028721-x6f26ahr 3381 30 and and CC cord-028721-x6f26ahr 3381 31 adhesives adhesive NNS cord-028721-x6f26ahr 3381 32 ; ; : cord-028721-x6f26ahr 3381 33 this this DT cord-028721-x6f26ahr 3381 34 is be VBZ cord-028721-x6f26ahr 3381 35 also also RB cord-028721-x6f26ahr 3381 36 the the DT cord-028721-x6f26ahr 3381 37 case case NN cord-028721-x6f26ahr 3381 38 with with IN cord-028721-x6f26ahr 3381 39 carbon carbon NN cord-028721-x6f26ahr 3381 40 disulfi disulfi NNP cord-028721-x6f26ahr 3381 41 de de IN cord-028721-x6f26ahr 3381 42 exposure exposure NN cord-028721-x6f26ahr 3381 43 ; ; : cord-028721-x6f26ahr 3381 44 pesticides pesticide NNS cord-028721-x6f26ahr 3381 45 such such JJ cord-028721-x6f26ahr 3381 46 as as IN cord-028721-x6f26ahr 3381 47 DDT DDT NNP cord-028721-x6f26ahr 3381 48 , , , cord-028721-x6f26ahr 3381 49 linuron linuron NNP cord-028721-x6f26ahr 3381 50 , , , cord-028721-x6f26ahr 3381 51 and and CC cord-028721-x6f26ahr 3381 52 polychlorinated polychlorinated JJ cord-028721-x6f26ahr 3381 53 biphenyls biphenyl NNS cord-028721-x6f26ahr 3381 54 ; ; : cord-028721-x6f26ahr 3381 55 1422 1422 CD cord-028721-x6f26ahr 3381 56 heavy heavy JJ cord-028721-x6f26ahr 3381 57 metals metal NNS cord-028721-x6f26ahr 3381 58 such such JJ cord-028721-x6f26ahr 3381 59 as as IN cord-028721-x6f26ahr 3381 60 lead lead NN cord-028721-x6f26ahr 3381 61 , , , cord-028721-x6f26ahr 3381 62 cadmium cadmium NN cord-028721-x6f26ahr 3381 63 , , , cord-028721-x6f26ahr 3381 64 mercury mercury NN cord-028721-x6f26ahr 3381 65 , , , cord-028721-x6f26ahr 3381 66 and and CC cord-028721-x6f26ahr 3381 67 copper copper NN cord-028721-x6f26ahr 3381 68 ; ; : cord-028721-x6f26ahr 3381 69 industrial industrial JJ cord-028721-x6f26ahr 3381 70 wastes waste NNS cord-028721-x6f26ahr 3381 71 such such JJ cord-028721-x6f26ahr 3381 72 as as IN cord-028721-x6f26ahr 3381 73 dioxins dioxin NNS cord-028721-x6f26ahr 3381 74 and and CC cord-028721-x6f26ahr 3381 75 ethylene ethylene NN cord-028721-x6f26ahr 3381 76 dibromide dibromide NN cord-028721-x6f26ahr 3381 77 ; ; : cord-028721-x6f26ahr 3381 78 phthalates phthalate NNS cord-028721-x6f26ahr 3381 79 and and CC cord-028721-x6f26ahr 3381 80 polyvinyl polyvinyl NN cord-028721-x6f26ahr 3381 81 chloride chloride NN cord-028721-x6f26ahr 3381 82 ; ; : cord-028721-x6f26ahr 3381 83 oral oral JJ cord-028721-x6f26ahr 3381 84 contraceptives contraceptive NNS cord-028721-x6f26ahr 3381 85 ; ; : cord-028721-x6f26ahr 3381 86 exposure exposure NN cord-028721-x6f26ahr 3381 87 to to IN cord-028721-x6f26ahr 3381 88 radiation radiation NN cord-028721-x6f26ahr 3381 89 or or CC cord-028721-x6f26ahr 3381 90 high high JJ cord-028721-x6f26ahr 3381 91 temperature temperature NN cord-028721-x6f26ahr 3381 92 ; ; : cord-028721-x6f26ahr 3381 93 and and CC cord-028721-x6f26ahr 3381 94 recreational recreational JJ cord-028721-x6f26ahr 3381 95 drugs drug NNS cord-028721-x6f26ahr 3381 96 and and CC cord-028721-x6f26ahr 3381 97 doping doping NN cord-028721-x6f26ahr 3381 98 . . . cord-028721-x6f26ahr 3382 1 There there EX cord-028721-x6f26ahr 3382 2 is be VBZ cord-028721-x6f26ahr 3382 3 also also RB cord-028721-x6f26ahr 3382 4 a a DT cord-028721-x6f26ahr 3382 5 long long JJ cord-028721-x6f26ahr 3382 6 list list NN cord-028721-x6f26ahr 3382 7 of of IN cord-028721-x6f26ahr 3382 8 potentially potentially RB cord-028721-x6f26ahr 3382 9 harmful harmful JJ cord-028721-x6f26ahr 3382 10 agents agent NNS cord-028721-x6f26ahr 3382 11 that that WDT cord-028721-x6f26ahr 3382 12 disrupt disrupt VBP cord-028721-x6f26ahr 3382 13 testicular testicular JJ cord-028721-x6f26ahr 3382 14 function function NN cord-028721-x6f26ahr 3382 15 . . . cord-028721-x6f26ahr 3383 1 1423 1423 CD cord-028721-x6f26ahr 3384 1 Carbon carbon NN cord-028721-x6f26ahr 3384 2 disulfi disulfi NN cord-028721-x6f26ahr 3384 3 de de NN cord-028721-x6f26ahr 3384 4 is be VBZ cord-028721-x6f26ahr 3384 5 used use VBN cord-028721-x6f26ahr 3384 6 as as IN cord-028721-x6f26ahr 3384 7 a a DT cord-028721-x6f26ahr 3384 8 solvent solvent NN cord-028721-x6f26ahr 3384 9 in in IN cord-028721-x6f26ahr 3384 10 the the DT cord-028721-x6f26ahr 3384 11 production production NN cord-028721-x6f26ahr 3384 12 of of IN cord-028721-x6f26ahr 3384 13 rayon rayon NN cord-028721-x6f26ahr 3384 14 . . . cord-028721-x6f26ahr 3385 1 Continuous continuous JJ cord-028721-x6f26ahr 3385 2 exposure exposure NN cord-028721-x6f26ahr 3385 3 is be VBZ cord-028721-x6f26ahr 3385 4 toxic toxic JJ cord-028721-x6f26ahr 3385 5 to to IN cord-028721-x6f26ahr 3385 6 the the DT cord-028721-x6f26ahr 3385 7 nervous nervous JJ cord-028721-x6f26ahr 3385 8 system system NN cord-028721-x6f26ahr 3385 9 , , , cord-028721-x6f26ahr 3385 10 and and CC cord-028721-x6f26ahr 3385 11 causes cause VBZ cord-028721-x6f26ahr 3385 12 a a DT cord-028721-x6f26ahr 3385 13 decrease decrease NN cord-028721-x6f26ahr 3385 14 in in IN cord-028721-x6f26ahr 3385 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3385 16 and and CC cord-028721-x6f26ahr 3385 17 libido libido NN cord-028721-x6f26ahr 3385 18 and and CC cord-028721-x6f26ahr 3385 19 an an DT cord-028721-x6f26ahr 3385 20 increase increase NN cord-028721-x6f26ahr 3385 21 in in IN cord-028721-x6f26ahr 3385 22 FSH fsh NN cord-028721-x6f26ahr 3385 23 and and CC cord-028721-x6f26ahr 3385 24 LH LH NNP cord-028721-x6f26ahr 3385 25 serum serum NN cord-028721-x6f26ahr 3385 26 levels level NNS cord-028721-x6f26ahr 3385 27 . . . cord-028721-x6f26ahr 3386 1 1424 1424 CD cord-028721-x6f26ahr 3386 2 , , , cord-028721-x6f26ahr 3386 3 1425 1425 CD cord-028721-x6f26ahr 3386 4 Dibromochloropropane Dibromochloropropane NNP cord-028721-x6f26ahr 3386 5 Dibromochloropropane Dibromochloropropane NNP cord-028721-x6f26ahr 3386 6 is be VBZ cord-028721-x6f26ahr 3386 7 used use VBN cord-028721-x6f26ahr 3386 8 as as IN cord-028721-x6f26ahr 3386 9 a a DT cord-028721-x6f26ahr 3386 10 soil soil NN cord-028721-x6f26ahr 3386 11 fumigant fumigant NN cord-028721-x6f26ahr 3386 12 to to TO cord-028721-x6f26ahr 3386 13 control control VB cord-028721-x6f26ahr 3386 14 nematodes nematode NNS cord-028721-x6f26ahr 3386 15 . . . cord-028721-x6f26ahr 3387 1 Lengthy lengthy JJ cord-028721-x6f26ahr 3387 2 exposure exposure NN cord-028721-x6f26ahr 3387 3 causes cause VBZ cord-028721-x6f26ahr 3387 4 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3387 5 , , , cord-028721-x6f26ahr 3387 6 azoospermia azoospermia NN cord-028721-x6f26ahr 3387 7 , , , cord-028721-x6f26ahr 3387 8 increased increase VBN cord-028721-x6f26ahr 3387 9 FSH fsh NN cord-028721-x6f26ahr 3387 10 and and CC cord-028721-x6f26ahr 3387 11 LH LH NNP cord-028721-x6f26ahr 3387 12 levels level NNS cord-028721-x6f26ahr 3387 13 , , , cord-028721-x6f26ahr 3387 14 and and CC cord-028721-x6f26ahr 3387 15 Y y NN cord-028721-x6f26ahr 3387 16 - - HYPH cord-028721-x6f26ahr 3387 17 chromosome chromosome NN cord-028721-x6f26ahr 3387 18 non non JJ cord-028721-x6f26ahr 3387 19 - - JJ cord-028721-x6f26ahr 3387 20 dysjunction dysjunction JJ cord-028721-x6f26ahr 3387 21 . . . cord-028721-x6f26ahr 3388 1 1426 1426 CD cord-028721-x6f26ahr 3388 2 _SP cord-028721-x6f26ahr 3389 1 Of of IN cord-028721-x6f26ahr 3389 2 the the DT cord-028721-x6f26ahr 3389 3 two two CD cord-028721-x6f26ahr 3389 4 natural natural JJ cord-028721-x6f26ahr 3389 5 forms form NNS cord-028721-x6f26ahr 3389 6 of of IN cord-028721-x6f26ahr 3389 7 lead lead NN cord-028721-x6f26ahr 3389 8 , , , cord-028721-x6f26ahr 3389 9 organic organic JJ cord-028721-x6f26ahr 3389 10 and and CC cord-028721-x6f26ahr 3389 11 inorganic inorganic JJ cord-028721-x6f26ahr 3389 12 , , , cord-028721-x6f26ahr 3389 13 the the DT cord-028721-x6f26ahr 3389 14 inorganic inorganic JJ cord-028721-x6f26ahr 3389 15 form form NN cord-028721-x6f26ahr 3389 16 is be VBZ cord-028721-x6f26ahr 3389 17 more more RBR cord-028721-x6f26ahr 3389 18 dangerous dangerous JJ cord-028721-x6f26ahr 3389 19 . . . cord-028721-x6f26ahr 3390 1 Exposure exposure NN cord-028721-x6f26ahr 3390 2 to to IN cord-028721-x6f26ahr 3390 3 inorganic inorganic JJ cord-028721-x6f26ahr 3390 4 lead lead NN cord-028721-x6f26ahr 3390 5 by by IN cord-028721-x6f26ahr 3390 6 workers worker NNS cord-028721-x6f26ahr 3390 7 in in IN cord-028721-x6f26ahr 3390 8 smelting smelting NN cord-028721-x6f26ahr 3390 9 , , , cord-028721-x6f26ahr 3390 10 battery battery NN cord-028721-x6f26ahr 3390 11 , , , cord-028721-x6f26ahr 3390 12 and and CC cord-028721-x6f26ahr 3390 13 stained stain VBN cord-028721-x6f26ahr 3390 14 - - HYPH cord-028721-x6f26ahr 3390 15 glass glass NN cord-028721-x6f26ahr 3390 16 plants plant NNS cord-028721-x6f26ahr 3390 17 causes cause VBZ cord-028721-x6f26ahr 3390 18 direct direct JJ cord-028721-x6f26ahr 3390 19 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 3390 20 damage damage NN cord-028721-x6f26ahr 3390 21 . . . cord-028721-x6f26ahr 3391 1 1427 1427 CD cord-028721-x6f26ahr 3391 2 Patients patient NNS cord-028721-x6f26ahr 3391 3 have have VBP cord-028721-x6f26ahr 3391 4 asthenospermia asthenospermia NN cord-028721-x6f26ahr 3391 5 , , , cord-028721-x6f26ahr 3391 6 teratozoospermia teratozoospermia NN cord-028721-x6f26ahr 3391 7 , , , cord-028721-x6f26ahr 3391 8 and and CC cord-028721-x6f26ahr 3391 9 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3391 10 . . . cord-028721-x6f26ahr 3392 1 1428 1428 CD cord-028721-x6f26ahr 3392 2 , , , cord-028721-x6f26ahr 3392 3 1429 1429 CD cord-028721-x6f26ahr 3392 4 Oral oral JJ cord-028721-x6f26ahr 3392 5 contraceptive contraceptive NN cord-028721-x6f26ahr 3392 6 manufacture manufacture NN cord-028721-x6f26ahr 3392 7 Workers worker NNS cord-028721-x6f26ahr 3392 8 in in IN cord-028721-x6f26ahr 3392 9 pharmaceutical pharmaceutical JJ cord-028721-x6f26ahr 3392 10 plants plant NNS cord-028721-x6f26ahr 3392 11 using use VBG cord-028721-x6f26ahr 3392 12 synthetic synthetic JJ cord-028721-x6f26ahr 3392 13 estrogens estrogen NNS cord-028721-x6f26ahr 3392 14 and and CC cord-028721-x6f26ahr 3392 15 progestins progestin NNS cord-028721-x6f26ahr 3392 16 develop develop VBP cord-028721-x6f26ahr 3392 17 hyperestrogenism hyperestrogenism NN cord-028721-x6f26ahr 3392 18 with with IN cord-028721-x6f26ahr 3392 19 gynecomastia gynecomastia NN cord-028721-x6f26ahr 3392 20 , , , cord-028721-x6f26ahr 3392 21 decreased decrease VBD cord-028721-x6f26ahr 3392 22 libido libido NN cord-028721-x6f26ahr 3392 23 , , , cord-028721-x6f26ahr 3392 24 and and CC cord-028721-x6f26ahr 3392 25 impotence impotence NN cord-028721-x6f26ahr 3392 26 . . . cord-028721-x6f26ahr 3393 1 1430 1430 CD cord-028721-x6f26ahr 3393 2 Neonatal neonatal JJ cord-028721-x6f26ahr 3393 3 exposure exposure NN cord-028721-x6f26ahr 3393 4 of of IN cord-028721-x6f26ahr 3393 5 males male NNS cord-028721-x6f26ahr 3393 6 to to IN cord-028721-x6f26ahr 3393 7 diethylstilbestrol diethylstilbestrol NN cord-028721-x6f26ahr 3393 8 may may MD cord-028721-x6f26ahr 3393 9 induce induce VB cord-028721-x6f26ahr 3393 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3393 11 , , , cord-028721-x6f26ahr 3393 12 testicular testicular JJ cord-028721-x6f26ahr 3393 13 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3393 14 , , , cord-028721-x6f26ahr 3393 15 epididymal epididymal JJ cord-028721-x6f26ahr 3393 16 cyst cyst NN cord-028721-x6f26ahr 3393 17 , , , cord-028721-x6f26ahr 3393 18 and and CC cord-028721-x6f26ahr 3393 19 severe severe JJ cord-028721-x6f26ahr 3393 20 anomalies anomaly NNS cord-028721-x6f26ahr 3393 21 in in IN cord-028721-x6f26ahr 3393 22 semen semen NN cord-028721-x6f26ahr 3393 23 production production NN cord-028721-x6f26ahr 3393 24 . . . cord-028721-x6f26ahr 3394 1 1431 1431 LS cord-028721-x6f26ahr 3394 2 There there EX cord-028721-x6f26ahr 3394 3 is be VBZ cord-028721-x6f26ahr 3394 4 increasing increase VBG cord-028721-x6f26ahr 3394 5 evidence evidence NN cord-028721-x6f26ahr 3394 6 to to TO cord-028721-x6f26ahr 3394 7 suggest suggest VB cord-028721-x6f26ahr 3394 8 that that IN cord-028721-x6f26ahr 3394 9 estrogen estrogen NN cord-028721-x6f26ahr 3394 10 - - HYPH cord-028721-x6f26ahr 3394 11 like like JJ cord-028721-x6f26ahr 3394 12 effects effect NNS cord-028721-x6f26ahr 3394 13 are be VBP cord-028721-x6f26ahr 3394 14 produced produce VBN cord-028721-x6f26ahr 3394 15 by by IN cord-028721-x6f26ahr 3394 16 a a DT cord-028721-x6f26ahr 3394 17 variety variety NN cord-028721-x6f26ahr 3394 18 of of IN cord-028721-x6f26ahr 3394 19 naturally naturally RB cord-028721-x6f26ahr 3394 20 occurring occur VBG cord-028721-x6f26ahr 3394 21 estrogens estrogen NNS cord-028721-x6f26ahr 3394 22 ( ( -LRB- cord-028721-x6f26ahr 3394 23 so so RB cord-028721-x6f26ahr 3394 24 - - HYPH cord-028721-x6f26ahr 3394 25 called call VBN cord-028721-x6f26ahr 3394 26 phytoestrogens phytoestrogen NNS cord-028721-x6f26ahr 3394 27 ) ) -RRB- cord-028721-x6f26ahr 3394 28 and and CC cord-028721-x6f26ahr 3394 29 numerous numerous JJ cord-028721-x6f26ahr 3394 30 synthetic synthetic JJ cord-028721-x6f26ahr 3394 31 compounds compound NNS cord-028721-x6f26ahr 3394 32 such such JJ cord-028721-x6f26ahr 3394 33 as as IN cord-028721-x6f26ahr 3394 34 phthalates phthalate NNS cord-028721-x6f26ahr 3394 35 , , , cord-028721-x6f26ahr 3394 36 1432 1432 CD cord-028721-x6f26ahr 3394 37 pesticides pesticide NNS cord-028721-x6f26ahr 3394 38 , , , cord-028721-x6f26ahr 3394 39 1433 1433 CD cord-028721-x6f26ahr 3394 40 and and CC cord-028721-x6f26ahr 3394 41 polychlorinated polychlorinated JJ cord-028721-x6f26ahr 3394 42 biphenyls biphenyl NNS cord-028721-x6f26ahr 3394 43 . . . cord-028721-x6f26ahr 3395 1 1434 1434 CD cord-028721-x6f26ahr 3396 1 The the DT cord-028721-x6f26ahr 3396 2 principal principal JJ cord-028721-x6f26ahr 3396 3 methods method NNS cord-028721-x6f26ahr 3396 4 of of IN cord-028721-x6f26ahr 3396 5 contact contact NN cord-028721-x6f26ahr 3396 6 with with IN cord-028721-x6f26ahr 3396 7 potential potential JJ cord-028721-x6f26ahr 3396 8 endocrine endocrine NN cord-028721-x6f26ahr 3396 9 - - HYPH cord-028721-x6f26ahr 3396 10 disrupting disrupt VBG cord-028721-x6f26ahr 3396 11 compounds compound NNS cord-028721-x6f26ahr 3396 12 is be VBZ cord-028721-x6f26ahr 3396 13 dietary dietary JJ cord-028721-x6f26ahr 3396 14 ingestion ingestion NN cord-028721-x6f26ahr 3396 15 of of IN cord-028721-x6f26ahr 3396 16 milk milk NN cord-028721-x6f26ahr 3396 17 , , , cord-028721-x6f26ahr 3396 18 fi fi NNP cord-028721-x6f26ahr 3396 19 sh sh NNP cord-028721-x6f26ahr 3396 20 , , , cord-028721-x6f26ahr 3396 21 meat meat NN cord-028721-x6f26ahr 3396 22 , , , cord-028721-x6f26ahr 3396 23 fruits fruit NNS cord-028721-x6f26ahr 3396 24 and and CC cord-028721-x6f26ahr 3396 25 vegetables vegetable NNS cord-028721-x6f26ahr 3396 26 , , , cord-028721-x6f26ahr 3396 27 or or CC cord-028721-x6f26ahr 3396 28 environmental environmental JJ cord-028721-x6f26ahr 3396 29 exposure exposure NN cord-028721-x6f26ahr 3396 30 . . . cord-028721-x6f26ahr 3397 1 1435 1435 CD cord-028721-x6f26ahr 3398 1 The the DT cord-028721-x6f26ahr 3398 2 increasing increase VBG cord-028721-x6f26ahr 3398 3 incidence incidence NN cord-028721-x6f26ahr 3398 4 of of IN cord-028721-x6f26ahr 3398 5 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3398 6 , , , cord-028721-x6f26ahr 3398 7 hypospadias hypospadia NNS cord-028721-x6f26ahr 3398 8 , , , cord-028721-x6f26ahr 3398 9 testicular testicular JJ cord-028721-x6f26ahr 3398 10 cancer cancer NN cord-028721-x6f26ahr 3398 11 , , , cord-028721-x6f26ahr 3398 12 and and CC cord-028721-x6f26ahr 3398 13 poor poor JJ cord-028721-x6f26ahr 3398 14 semen semen NN cord-028721-x6f26ahr 3398 15 quality quality NN cord-028721-x6f26ahr 3398 16 may may MD cord-028721-x6f26ahr 3398 17 be be VB cord-028721-x6f26ahr 3398 18 related relate VBN cord-028721-x6f26ahr 3398 19 to to IN cord-028721-x6f26ahr 3398 20 the the DT cord-028721-x6f26ahr 3398 21 negative negative JJ cord-028721-x6f26ahr 3398 22 infl infl NN cord-028721-x6f26ahr 3398 23 uence uence NN cord-028721-x6f26ahr 3398 24 of of IN cord-028721-x6f26ahr 3398 25 environmental environmental JJ cord-028721-x6f26ahr 3398 26 factors factor NNS cord-028721-x6f26ahr 3398 27 on on IN cord-028721-x6f26ahr 3398 28 the the DT cord-028721-x6f26ahr 3398 29 testis testis NN cord-028721-x6f26ahr 3398 30 during during IN cord-028721-x6f26ahr 3398 31 fetal fetal JJ cord-028721-x6f26ahr 3398 32 life life NN cord-028721-x6f26ahr 3398 33 . . . cord-028721-x6f26ahr 3399 1 The the DT cord-028721-x6f26ahr 3399 2 term term NN cord-028721-x6f26ahr 3399 3 ' ' `` cord-028721-x6f26ahr 3399 4 testicular testicular NNP cord-028721-x6f26ahr 3399 5 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 3399 6 syndrome syndrome NN cord-028721-x6f26ahr 3399 7 ' ' '' cord-028721-x6f26ahr 3399 8 has have VBZ cord-028721-x6f26ahr 3399 9 been be VBN cord-028721-x6f26ahr 3399 10 proposed propose VBN cord-028721-x6f26ahr 3399 11 to to TO cord-028721-x6f26ahr 3399 12 designate designate VB cord-028721-x6f26ahr 3399 13 this this DT cord-028721-x6f26ahr 3399 14 constellation constellation NN cord-028721-x6f26ahr 3399 15 of of IN cord-028721-x6f26ahr 3399 16 putative putative JJ cord-028721-x6f26ahr 3399 17 syndromes syndrome NNS cord-028721-x6f26ahr 3399 18 . . . cord-028721-x6f26ahr 3400 1 1436 1436 CD cord-028721-x6f26ahr 3400 2 Estrogen estrogen NN cord-028721-x6f26ahr 3400 3 exposure exposure NN cord-028721-x6f26ahr 3400 4 in in IN cord-028721-x6f26ahr 3400 5 utero utero NN cord-028721-x6f26ahr 3400 6 may may MD cord-028721-x6f26ahr 3400 7 disrupt disrupt VB cord-028721-x6f26ahr 3400 8 development development NN cord-028721-x6f26ahr 3400 9 of of IN cord-028721-x6f26ahr 3400 10 the the DT cord-028721-x6f26ahr 3400 11 testes testis NNS cord-028721-x6f26ahr 3400 12 and and CC cord-028721-x6f26ahr 3400 13 the the DT cord-028721-x6f26ahr 3400 14 entire entire JJ cord-028721-x6f26ahr 3400 15 male male JJ cord-028721-x6f26ahr 3400 16 reproductive reproductive JJ cord-028721-x6f26ahr 3400 17 tract tract NN cord-028721-x6f26ahr 3400 18 . . . cord-028721-x6f26ahr 3401 1 Estrogen estrogen NN cord-028721-x6f26ahr 3401 2 may may MD cord-028721-x6f26ahr 3401 3 hinder hinder VB cord-028721-x6f26ahr 3401 4 FSH fsh NN cord-028721-x6f26ahr 3401 5 secretion secretion NN cord-028721-x6f26ahr 3401 6 by by IN cord-028721-x6f26ahr 3401 7 the the DT cord-028721-x6f26ahr 3401 8 fetal fetal JJ cord-028721-x6f26ahr 3401 9 pituitary pituitary NN cord-028721-x6f26ahr 3401 10 , , , cord-028721-x6f26ahr 3401 11 and and CC cord-028721-x6f26ahr 3401 12 also also RB cord-028721-x6f26ahr 3401 13 interfere interfere VB cord-028721-x6f26ahr 3401 14 with with IN cord-028721-x6f26ahr 3401 15 subsequent subsequent JJ cord-028721-x6f26ahr 3401 16 Sertoli sertoli JJ cord-028721-x6f26ahr 3401 17 cell cell NN cord-028721-x6f26ahr 3401 18 proliferation proliferation NN cord-028721-x6f26ahr 3401 19 , , , cord-028721-x6f26ahr 3401 20 and and CC cord-028721-x6f26ahr 3401 21 hence hence RB cord-028721-x6f26ahr 3401 22 the the DT cord-028721-x6f26ahr 3401 23 secretion secretion NN cord-028721-x6f26ahr 3401 24 of of IN cord-028721-x6f26ahr 3401 25 AMH amh NN cord-028721-x6f26ahr 3401 26 required require VBN cord-028721-x6f26ahr 3401 27 for for IN cord-028721-x6f26ahr 3401 28 the the DT cord-028721-x6f26ahr 3401 29 regression regression NN cord-028721-x6f26ahr 3401 30 of of IN cord-028721-x6f26ahr 3401 31 müllerian müllerian JJ cord-028721-x6f26ahr 3401 32 ducts duct NNS cord-028721-x6f26ahr 3401 33 . . . cord-028721-x6f26ahr 3402 1 Persistence persistence NN cord-028721-x6f26ahr 3402 2 of of IN cord-028721-x6f26ahr 3402 3 müllerian müllerian JJ cord-028721-x6f26ahr 3402 4 derivatives derivative NNS cord-028721-x6f26ahr 3402 5 is be VBZ cord-028721-x6f26ahr 3402 6 associated associate VBN cord-028721-x6f26ahr 3402 7 with with IN cord-028721-x6f26ahr 3402 8 lack lack NN cord-028721-x6f26ahr 3402 9 of of IN cord-028721-x6f26ahr 3402 10 testicular testicular JJ cord-028721-x6f26ahr 3402 11 descent descent NN cord-028721-x6f26ahr 3402 12 . . . cord-028721-x6f26ahr 3403 1 Changes change NNS cord-028721-x6f26ahr 3403 2 in in IN cord-028721-x6f26ahr 3403 3 AMH AMH NNP cord-028721-x6f26ahr 3403 4 secretion secretion NN cord-028721-x6f26ahr 3403 5 may may MD cord-028721-x6f26ahr 3403 6 also also RB cord-028721-x6f26ahr 3403 7 account account VB cord-028721-x6f26ahr 3403 8 for for IN cord-028721-x6f26ahr 3403 9 altered altered JJ cord-028721-x6f26ahr 3403 10 germ germ NN cord-028721-x6f26ahr 3403 11 cell cell NN cord-028721-x6f26ahr 3403 12 proliferation proliferation NN cord-028721-x6f26ahr 3403 13 during during IN cord-028721-x6f26ahr 3403 14 fetal fetal JJ cord-028721-x6f26ahr 3403 15 life life NN cord-028721-x6f26ahr 3403 16 . . . cord-028721-x6f26ahr 3404 1 Exposure exposure NN cord-028721-x6f26ahr 3404 2 to to IN cord-028721-x6f26ahr 3404 3 high high JJ cord-028721-x6f26ahr 3404 4 concentrations concentration NNS cord-028721-x6f26ahr 3404 5 of of IN cord-028721-x6f26ahr 3404 6 estrogen estrogen NN cord-028721-x6f26ahr 3404 7 might may MD cord-028721-x6f26ahr 3404 8 compromise compromise VB cord-028721-x6f26ahr 3404 9 testosterone testosterone NN cord-028721-x6f26ahr 3404 10 production production NN cord-028721-x6f26ahr 3404 11 as as RB cord-028721-x6f26ahr 3404 12 well well RB cord-028721-x6f26ahr 3404 13 as as IN cord-028721-x6f26ahr 3404 14 masculinization masculinization NN cord-028721-x6f26ahr 3404 15 of of IN cord-028721-x6f26ahr 3404 16 external external JJ cord-028721-x6f26ahr 3404 17 genitalia genitalia NNS cord-028721-x6f26ahr 3404 18 ( ( -LRB- cord-028721-x6f26ahr 3404 19 hypospadias hypospadia NNS cord-028721-x6f26ahr 3404 20 ) ) -RRB- cord-028721-x6f26ahr 3404 21 and and CC cord-028721-x6f26ahr 3404 22 inguinal inguinal JJ cord-028721-x6f26ahr 3404 23 descent descent NN cord-028721-x6f26ahr 3404 24 of of IN cord-028721-x6f26ahr 3404 25 the the DT cord-028721-x6f26ahr 3404 26 testis testis NN cord-028721-x6f26ahr 3404 27 ( ( -LRB- cord-028721-x6f26ahr 3404 28 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3404 29 ) ) -RRB- cord-028721-x6f26ahr 3404 30 . . . cord-028721-x6f26ahr 3405 1 Abnormal abnormal JJ cord-028721-x6f26ahr 3405 2 development development NN cord-028721-x6f26ahr 3405 3 of of IN cord-028721-x6f26ahr 3405 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 3405 5 cells cell NNS cord-028721-x6f26ahr 3405 6 and and CC cord-028721-x6f26ahr 3405 7 low low JJ cord-028721-x6f26ahr 3405 8 germ germ NN cord-028721-x6f26ahr 3405 9 cell cell NN cord-028721-x6f26ahr 3405 10 numbers number NNS cord-028721-x6f26ahr 3405 11 could could MD cord-028721-x6f26ahr 3405 12 cause cause VB cord-028721-x6f26ahr 3405 13 diminished diminished JJ cord-028721-x6f26ahr 3405 14 spermatozoon spermatozoon NN cord-028721-x6f26ahr 3405 15 production production NN cord-028721-x6f26ahr 3405 16 and and CC cord-028721-x6f26ahr 3405 17 infertility infertility NN cord-028721-x6f26ahr 3405 18 . . . cord-028721-x6f26ahr 3406 1 1437 1437 CD cord-028721-x6f26ahr 3406 2 _SP cord-028721-x6f26ahr 3407 1 Marijuana marijuana NN cord-028721-x6f26ahr 3407 2 decreases decrease VBZ cord-028721-x6f26ahr 3407 3 sperm sperm NN cord-028721-x6f26ahr 3407 4 density density NN cord-028721-x6f26ahr 3407 5 and and CC cord-028721-x6f26ahr 3407 6 motility motility NN cord-028721-x6f26ahr 3407 7 and and CC cord-028721-x6f26ahr 3407 8 increases increase VBZ cord-028721-x6f26ahr 3407 9 the the DT cord-028721-x6f26ahr 3407 10 number number NN cord-028721-x6f26ahr 3407 11 of of IN cord-028721-x6f26ahr 3407 12 morphologically morphologically RB cord-028721-x6f26ahr 3407 13 abnormal abnormal JJ cord-028721-x6f26ahr 3407 14 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3407 15 . . . cord-028721-x6f26ahr 3408 1 1438 1438 CD cord-028721-x6f26ahr 3409 1 Cocaine cocaine NN cord-028721-x6f26ahr 3409 2 induces induce VBZ cord-028721-x6f26ahr 3409 3 apoptosis apoptosis NN cord-028721-x6f26ahr 3409 4 in in IN cord-028721-x6f26ahr 3409 5 the the DT cord-028721-x6f26ahr 3409 6 rat rat NN cord-028721-x6f26ahr 3409 7 testis testis NN cord-028721-x6f26ahr 3409 8 ( ( -LRB- cord-028721-x6f26ahr 3409 9 Fig Fig NNP cord-028721-x6f26ahr 3409 10 . . . cord-028721-x6f26ahr 3409 11 12 12 CD cord-028721-x6f26ahr 3409 12 - - SYM cord-028721-x6f26ahr 3409 13 153 153 CD cord-028721-x6f26ahr 3409 14 ) ) -RRB- cord-028721-x6f26ahr 3409 15 . . . cord-028721-x6f26ahr 3410 1 1439 1439 CD cord-028721-x6f26ahr 3410 2 About about IN cord-028721-x6f26ahr 3410 3 20 20 CD cord-028721-x6f26ahr 3410 4 % % NN cord-028721-x6f26ahr 3410 5 of of IN cord-028721-x6f26ahr 3410 6 injection injection NN cord-028721-x6f26ahr 3410 7 drug drug NN cord-028721-x6f26ahr 3410 8 users user NNS cord-028721-x6f26ahr 3410 9 have have VBP cord-028721-x6f26ahr 3410 10 low low JJ cord-028721-x6f26ahr 3410 11 serum serum NN cord-028721-x6f26ahr 3410 12 testosterone testosterone NN cord-028721-x6f26ahr 3410 13 levels level NNS cord-028721-x6f26ahr 3410 14 . . . cord-028721-x6f26ahr 3411 1 Consumption consumption NN cord-028721-x6f26ahr 3411 2 of of IN cord-028721-x6f26ahr 3411 3 more more JJR cord-028721-x6f26ahr 3411 4 than than IN cord-028721-x6f26ahr 3411 5 80 80 CD cord-028721-x6f26ahr 3411 6 g g NN cord-028721-x6f26ahr 3411 7 alcohol alcohol NN cord-028721-x6f26ahr 3411 8 per per IN cord-028721-x6f26ahr 3411 9 day day NN cord-028721-x6f26ahr 3411 10 adversely adversely RB cord-028721-x6f26ahr 3411 11 affects affect VBZ cord-028721-x6f26ahr 3411 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3411 13 in in IN cord-028721-x6f26ahr 3411 14 two two CD cord-028721-x6f26ahr 3411 15 - - HYPH cord-028721-x6f26ahr 3411 16 thirds third NNS cord-028721-x6f26ahr 3411 17 of of IN cord-028721-x6f26ahr 3411 18 patients patient NNS cord-028721-x6f26ahr 3411 19 . . . cord-028721-x6f26ahr 3412 1 1440 1440 CD cord-028721-x6f26ahr 3412 2 Women woman NNS cord-028721-x6f26ahr 3412 3 smoking smoke VBG cord-028721-x6f26ahr 3412 4 more more JJR cord-028721-x6f26ahr 3412 5 than than IN cord-028721-x6f26ahr 3412 6 20 20 CD cord-028721-x6f26ahr 3412 7 cigarettes cigarette NNS cord-028721-x6f26ahr 3412 8 per per IN cord-028721-x6f26ahr 3412 9 day day NN cord-028721-x6f26ahr 3412 10 have have VBP cord-028721-x6f26ahr 3412 11 fertility fertility NN cord-028721-x6f26ahr 3412 12 problems problem NNS cord-028721-x6f26ahr 3412 13 , , , cord-028721-x6f26ahr 3412 14 neonatal neonatal JJ cord-028721-x6f26ahr 3412 15 and and CC cord-028721-x6f26ahr 3412 16 perinatal perinatal JJ cord-028721-x6f26ahr 3412 17 mortality mortality NN cord-028721-x6f26ahr 3412 18 , , , cord-028721-x6f26ahr 3412 19 miscarriage miscarriage NN cord-028721-x6f26ahr 3412 20 , , , cord-028721-x6f26ahr 3412 21 and and CC cord-028721-x6f26ahr 3412 22 congenital congenital JJ cord-028721-x6f26ahr 3412 23 malformations malformation NNS cord-028721-x6f26ahr 3412 24 . . . cord-028721-x6f26ahr 3413 1 1441 1441 CD cord-028721-x6f26ahr 3413 2 Abuse abuse NN cord-028721-x6f26ahr 3413 3 of of IN cord-028721-x6f26ahr 3413 4 anabolic anabolic JJ cord-028721-x6f26ahr 3413 5 steroids steroid NNS cord-028721-x6f26ahr 3413 6 by by IN cord-028721-x6f26ahr 3413 7 athletes athlete NNS cord-028721-x6f26ahr 3413 8 causes cause VBZ cord-028721-x6f26ahr 3413 9 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3413 10 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3413 11 and and CC cord-028721-x6f26ahr 3413 12 transient transient JJ cord-028721-x6f26ahr 3413 13 azoospermia azoospermia NN cord-028721-x6f26ahr 3413 14 . . . cord-028721-x6f26ahr 3414 1 1442 1442 CD cord-028721-x6f26ahr 3414 2 _SP cord-028721-x6f26ahr 3415 1 Ionizing ionize VBG cord-028721-x6f26ahr 3415 2 radiation radiation NN cord-028721-x6f26ahr 3415 3 causes cause VBZ cord-028721-x6f26ahr 3415 4 alterations alteration NNS cord-028721-x6f26ahr 3415 5 in in IN cord-028721-x6f26ahr 3415 6 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3415 7 and and CC cord-028721-x6f26ahr 3415 8 hormonal hormonal JJ cord-028721-x6f26ahr 3415 9 regulation regulation NN cord-028721-x6f26ahr 3415 10 of of IN cord-028721-x6f26ahr 3415 11 the the DT cord-028721-x6f26ahr 3415 12 testes testis NNS cord-028721-x6f26ahr 3415 13 . . . cord-028721-x6f26ahr 3416 1 Some some DT cord-028721-x6f26ahr 3416 2 patients patient NNS cord-028721-x6f26ahr 3416 3 recover recover VBP cord-028721-x6f26ahr 3416 4 fertility fertility NN cord-028721-x6f26ahr 3416 5 a a DT cord-028721-x6f26ahr 3416 6 few few JJ cord-028721-x6f26ahr 3416 7 years year NNS cord-028721-x6f26ahr 3416 8 after after IN cord-028721-x6f26ahr 3416 9 exposure exposure NN cord-028721-x6f26ahr 3416 10 . . . cord-028721-x6f26ahr 3417 1 1443 1443 CD cord-028721-x6f26ahr 3418 1 The the DT cord-028721-x6f26ahr 3418 2 effects effect NNS cord-028721-x6f26ahr 3418 3 of of IN cord-028721-x6f26ahr 3418 4 non non JJ cord-028721-x6f26ahr 3418 5 - - JJ cord-028721-x6f26ahr 3418 6 ionizing ionizing JJ cord-028721-x6f26ahr 3418 7 radiation radiation NN cord-028721-x6f26ahr 3418 8 are be VBP cord-028721-x6f26ahr 3418 9 less less RBR cord-028721-x6f26ahr 3418 10 severe severe JJ cord-028721-x6f26ahr 3418 11 ; ; : cord-028721-x6f26ahr 3418 12 however however RB cord-028721-x6f26ahr 3418 13 , , , cord-028721-x6f26ahr 3418 14 reduced reduce VBN cord-028721-x6f26ahr 3418 15 libido libido NN cord-028721-x6f26ahr 3418 16 and and CC cord-028721-x6f26ahr 3418 17 reduced reduce VBN cord-028721-x6f26ahr 3418 18 numbers number NNS cord-028721-x6f26ahr 3418 19 of of IN cord-028721-x6f26ahr 3418 20 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3418 21 have have VBP cord-028721-x6f26ahr 3418 22 been be VBN cord-028721-x6f26ahr 3418 23 reported report VBN cord-028721-x6f26ahr 3418 24 in in IN cord-028721-x6f26ahr 3418 25 men man NNS cord-028721-x6f26ahr 3418 26 exposed expose VBN cord-028721-x6f26ahr 3418 27 to to IN cord-028721-x6f26ahr 3418 28 microwaves microwave NNS cord-028721-x6f26ahr 3418 29 . . . cord-028721-x6f26ahr 3419 1 1444 1444 CD cord-028721-x6f26ahr 3420 1 Heat heat VB cord-028721-x6f26ahr 3420 2 Normal normal JJ cord-028721-x6f26ahr 3420 3 intratesticular intratesticular JJ cord-028721-x6f26ahr 3420 4 temperature temperature NN cord-028721-x6f26ahr 3420 5 is be VBZ cord-028721-x6f26ahr 3420 6 31 31 CD cord-028721-x6f26ahr 3420 7 - - SYM cord-028721-x6f26ahr 3420 8 33 33 CD cord-028721-x6f26ahr 3420 9 ° ° NN cord-028721-x6f26ahr 3420 10 C c NN cord-028721-x6f26ahr 3420 11 , , , cord-028721-x6f26ahr 3420 12 about about RB cord-028721-x6f26ahr 3420 13 4 4 CD cord-028721-x6f26ahr 3420 14 - - SYM cord-028721-x6f26ahr 3420 15 6 6 CD cord-028721-x6f26ahr 3420 16 ° ° NN cord-028721-x6f26ahr 3420 17 C C NNP cord-028721-x6f26ahr 3420 18 lower low JJR cord-028721-x6f26ahr 3420 19 than than IN cord-028721-x6f26ahr 3420 20 core core NN cord-028721-x6f26ahr 3420 21 body body NN cord-028721-x6f26ahr 3420 22 temperature temperature NN cord-028721-x6f26ahr 3420 23 . . . cord-028721-x6f26ahr 3421 1 Conditions condition NNS cord-028721-x6f26ahr 3421 2 causing cause VBG cord-028721-x6f26ahr 3421 3 higher high JJR cord-028721-x6f26ahr 3421 4 testicular testicular NN cord-028721-x6f26ahr 3421 5 temperature temperature NN cord-028721-x6f26ahr 3421 6 , , , cord-028721-x6f26ahr 3421 7 such such JJ cord-028721-x6f26ahr 3421 8 as as IN cord-028721-x6f26ahr 3421 9 varicocele varicocele NN cord-028721-x6f26ahr 3421 10 and and CC cord-028721-x6f26ahr 3421 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3421 12 , , , cord-028721-x6f26ahr 3421 13 also also RB cord-028721-x6f26ahr 3421 14 cause cause VB cord-028721-x6f26ahr 3421 15 testicular testicular JJ cord-028721-x6f26ahr 3421 16 damage damage NN cord-028721-x6f26ahr 3421 17 , , , cord-028721-x6f26ahr 3421 18 with with IN cord-028721-x6f26ahr 3421 19 decreased decrease VBN cord-028721-x6f26ahr 3421 20 numbers number NNS cord-028721-x6f26ahr 3421 21 of of IN cord-028721-x6f26ahr 3421 22 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3421 23 and and CC cord-028721-x6f26ahr 3421 24 an an DT cord-028721-x6f26ahr 3421 25 elevated elevated JJ cord-028721-x6f26ahr 3421 26 percentage percentage NN cord-028721-x6f26ahr 3421 27 of of IN cord-028721-x6f26ahr 3421 28 sper sper NN cord-028721-x6f26ahr 3421 29 - - HYPH cord-028721-x6f26ahr 3421 30 matozoa matozoa NNP cord-028721-x6f26ahr 3421 31 with with IN cord-028721-x6f26ahr 3421 32 abnormal abnormal JJ cord-028721-x6f26ahr 3421 33 forms form NNS cord-028721-x6f26ahr 3421 34 and and CC cord-028721-x6f26ahr 3421 35 low low JJ cord-028721-x6f26ahr 3421 36 motility motility NN cord-028721-x6f26ahr 3421 37 . . . cord-028721-x6f26ahr 3422 1 1445 1445 CD cord-028721-x6f26ahr 3422 2 , , , cord-028721-x6f26ahr 3422 3 1446 1446 CD cord-028721-x6f26ahr 3422 4 Primary primary JJ cord-028721-x6f26ahr 3422 5 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 3422 6 at at IN cord-028721-x6f26ahr 3422 7 the the DT cord-028721-x6f26ahr 3422 8 end end NN cord-028721-x6f26ahr 3422 9 of of IN cord-028721-x6f26ahr 3422 10 the the DT cord-028721-x6f26ahr 3422 11 pachytene pachytene JJ cord-028721-x6f26ahr 3422 12 stage stage NN cord-028721-x6f26ahr 3422 13 are be VBP cord-028721-x6f26ahr 3422 14 most most RBS cord-028721-x6f26ahr 3422 15 sensitive sensitive JJ cord-028721-x6f26ahr 3422 16 to to IN cord-028721-x6f26ahr 3422 17 heat heat VB cord-028721-x6f26ahr 3422 18 . . . cord-028721-x6f26ahr 3423 1 The the DT cord-028721-x6f26ahr 3423 2 mechanism mechanism NN cord-028721-x6f26ahr 3423 3 by by IN cord-028721-x6f26ahr 3423 4 which which WDT cord-028721-x6f26ahr 3423 5 heat heat NN cord-028721-x6f26ahr 3423 6 produces produce VBZ cord-028721-x6f26ahr 3423 7 testicular testicular JJ cord-028721-x6f26ahr 3423 8 lesions lesion NNS cord-028721-x6f26ahr 3423 9 is be VBZ cord-028721-x6f26ahr 3423 10 unknown unknown JJ cord-028721-x6f26ahr 3423 11 ; ; : cord-028721-x6f26ahr 3423 12 hyperthermia hyperthermia NN cord-028721-x6f26ahr 3423 13 affects affect VBZ cord-028721-x6f26ahr 3423 14 the the DT cord-028721-x6f26ahr 3423 15 activity activity NN cord-028721-x6f26ahr 3423 16 of of IN cord-028721-x6f26ahr 3423 17 enzymes enzyme NNS cord-028721-x6f26ahr 3423 18 such such JJ cord-028721-x6f26ahr 3423 19 as as IN cord-028721-x6f26ahr 3423 20 ornithine ornithine NN cord-028721-x6f26ahr 3423 21 decarboxylase decarboxylase NN cord-028721-x6f26ahr 3423 22 1447 1447 CD cord-028721-x6f26ahr 3423 23 and and CC cord-028721-x6f26ahr 3423 24 carnitine carnitine NN cord-028721-x6f26ahr 3423 25 acetyl acetyl NN cord-028721-x6f26ahr 3423 26 transferase transferase NN cord-028721-x6f26ahr 3423 27 , , , cord-028721-x6f26ahr 3423 28 1448 1448 CD cord-028721-x6f26ahr 3423 29 both both DT cord-028721-x6f26ahr 3423 30 necessary necessary JJ cord-028721-x6f26ahr 3423 31 for for IN cord-028721-x6f26ahr 3423 32 metabolism metabolism NN cord-028721-x6f26ahr 3423 33 and and CC cord-028721-x6f26ahr 3423 34 proliferation proliferation NN cord-028721-x6f26ahr 3423 35 of of IN cord-028721-x6f26ahr 3423 36 the the DT cord-028721-x6f26ahr 3423 37 seminiferous seminiferous JJ cord-028721-x6f26ahr 3423 38 tubular tubular JJ cord-028721-x6f26ahr 3423 39 cells cell NNS cord-028721-x6f26ahr 3423 40 . . . cord-028721-x6f26ahr 3424 1 1449 1449 CD cord-028721-x6f26ahr 3425 1 The the DT cord-028721-x6f26ahr 3425 2 synthesis synthesis NN cord-028721-x6f26ahr 3425 3 of of IN cord-028721-x6f26ahr 3425 4 DNA DNA NNP cord-028721-x6f26ahr 3425 5 and and CC cord-028721-x6f26ahr 3425 6 RNA RNA NNP cord-028721-x6f26ahr 3425 7 by by IN cord-028721-x6f26ahr 3425 8 germ germ NN cord-028721-x6f26ahr 3425 9 cells cell NNS cord-028721-x6f26ahr 3425 10 also also RB cord-028721-x6f26ahr 3425 11 depends depend VBZ cord-028721-x6f26ahr 3425 12 on on IN cord-028721-x6f26ahr 3425 13 temperature temperature NN cord-028721-x6f26ahr 3425 14 . . . cord-028721-x6f26ahr 3426 1 DNA dna NN cord-028721-x6f26ahr 3426 2 synthesis synthesis NN cord-028721-x6f26ahr 3426 3 by by IN cord-028721-x6f26ahr 3426 4 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3426 5 and and CC cord-028721-x6f26ahr 3426 6 preleptotene preleptotene NNP cord-028721-x6f26ahr 3426 7 primary primary JJ cord-028721-x6f26ahr 3426 8 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 3426 9 is be VBZ cord-028721-x6f26ahr 3426 10 higher high JJR cord-028721-x6f26ahr 3426 11 at at IN cord-028721-x6f26ahr 3426 12 31 31 CD cord-028721-x6f26ahr 3426 13 ° ° NN cord-028721-x6f26ahr 3426 14 C c NN cord-028721-x6f26ahr 3426 15 than than IN cord-028721-x6f26ahr 3426 16 at at IN cord-028721-x6f26ahr 3426 17 37 37 CD cord-028721-x6f26ahr 3426 18 ° ° NN cord-028721-x6f26ahr 3426 19 C c NN cord-028721-x6f26ahr 3426 20 . . . cord-028721-x6f26ahr 3427 1 RNA RNA NNP cord-028721-x6f26ahr 3427 2 and and CC cord-028721-x6f26ahr 3427 3 protein protein NN cord-028721-x6f26ahr 3427 4 synthesis synthesis NN cord-028721-x6f26ahr 3427 5 are be VBP cord-028721-x6f26ahr 3427 6 normal normal JJ cord-028721-x6f26ahr 3427 7 at at IN cord-028721-x6f26ahr 3427 8 temperatures temperature NNS cord-028721-x6f26ahr 3427 9 between between IN cord-028721-x6f26ahr 3427 10 28 28 CD cord-028721-x6f26ahr 3427 11 ° ° NN cord-028721-x6f26ahr 3427 12 C c NN cord-028721-x6f26ahr 3427 13 and and CC cord-028721-x6f26ahr 3427 14 37 37 CD cord-028721-x6f26ahr 3427 15 ° ° NN cord-028721-x6f26ahr 3427 16 C c NN cord-028721-x6f26ahr 3427 17 , , , cord-028721-x6f26ahr 3427 18 but but CC cord-028721-x6f26ahr 3427 19 decrease decrease VB cord-028721-x6f26ahr 3427 20 markedly markedly RB cord-028721-x6f26ahr 3427 21 at at IN cord-028721-x6f26ahr 3427 22 40 40 CD cord-028721-x6f26ahr 3427 23 ° ° NN cord-028721-x6f26ahr 3427 24 C c NN cord-028721-x6f26ahr 3427 25 . . . cord-028721-x6f26ahr 3428 1 1450 1450 CD cord-028721-x6f26ahr 3428 2 Testicular testicular JJ cord-028721-x6f26ahr 3428 3 trauma trauma NN cord-028721-x6f26ahr 3428 4 is be VBZ cord-028721-x6f26ahr 3428 5 especially especially RB cord-028721-x6f26ahr 3428 6 frequent frequent JJ cord-028721-x6f26ahr 3428 7 among among IN cord-028721-x6f26ahr 3428 8 athletes athlete NNS cord-028721-x6f26ahr 3428 9 . . . cord-028721-x6f26ahr 3429 1 Trauma trauma NN cord-028721-x6f26ahr 3429 2 results result NNS cord-028721-x6f26ahr 3429 3 in in IN cord-028721-x6f26ahr 3429 4 a a DT cord-028721-x6f26ahr 3429 5 wide wide JJ cord-028721-x6f26ahr 3429 6 variety variety NN cord-028721-x6f26ahr 3429 7 of of IN cord-028721-x6f26ahr 3429 8 lesions lesion NNS cord-028721-x6f26ahr 3429 9 , , , cord-028721-x6f26ahr 3429 10 including include VBG cord-028721-x6f26ahr 3429 11 contusion contusion NN cord-028721-x6f26ahr 3429 12 with with IN cord-028721-x6f26ahr 3429 13 or or CC cord-028721-x6f26ahr 3429 14 without without IN cord-028721-x6f26ahr 3429 15 hematocele hematocele NN cord-028721-x6f26ahr 3429 16 , , , cord-028721-x6f26ahr 3429 17 rupture rupture NN cord-028721-x6f26ahr 3429 18 , , , cord-028721-x6f26ahr 3429 19 dislocation dislocation NN cord-028721-x6f26ahr 3429 20 , , , cord-028721-x6f26ahr 3429 21 and and CC cord-028721-x6f26ahr 3429 22 eventually eventually RB cord-028721-x6f26ahr 3429 23 spermatogenetic spermatogenetic VBD cord-028721-x6f26ahr 3429 24 alteration alteration NN cord-028721-x6f26ahr 3429 25 that that WDT cord-028721-x6f26ahr 3429 26 may may MD cord-028721-x6f26ahr 3429 27 lead lead VB cord-028721-x6f26ahr 3429 28 to to IN cord-028721-x6f26ahr 3429 29 infertility infertility NN cord-028721-x6f26ahr 3429 30 . . . cord-028721-x6f26ahr 3430 1 Dislocation dislocation NN cord-028721-x6f26ahr 3430 2 involves involve VBZ cord-028721-x6f26ahr 3430 3 the the DT cord-028721-x6f26ahr 3430 4 displacement displacement NN cord-028721-x6f26ahr 3430 5 of of IN cord-028721-x6f26ahr 3430 6 one one CD cord-028721-x6f26ahr 3430 7 or or CC cord-028721-x6f26ahr 3430 8 both both DT cord-028721-x6f26ahr 3430 9 testes testis NNS cord-028721-x6f26ahr 3430 10 to to IN cord-028721-x6f26ahr 3430 11 a a DT cord-028721-x6f26ahr 3430 12 non non JJ cord-028721-x6f26ahr 3430 13 - - JJ cord-028721-x6f26ahr 3430 14 scrotal scrotal JJ cord-028721-x6f26ahr 3430 15 location location NN cord-028721-x6f26ahr 3430 16 1451 1451 CD cord-028721-x6f26ahr 3430 17 , , , cord-028721-x6f26ahr 3430 18 1452 1452 CD cord-028721-x6f26ahr 3430 19 such such JJ cord-028721-x6f26ahr 3430 20 as as IN cord-028721-x6f26ahr 3430 21 the the DT cord-028721-x6f26ahr 3430 22 inguinal inguinal JJ cord-028721-x6f26ahr 3430 23 canal canal NN cord-028721-x6f26ahr 3430 24 , , , cord-028721-x6f26ahr 3430 25 abdominal abdominal JJ cord-028721-x6f26ahr 3430 26 cavity cavity NN cord-028721-x6f26ahr 3430 27 , , , cord-028721-x6f26ahr 3430 28 acetabular acetabular JJ cord-028721-x6f26ahr 3430 29 area area NN cord-028721-x6f26ahr 3430 30 , , , cord-028721-x6f26ahr 3430 31 or or CC cord-028721-x6f26ahr 3430 32 distant distant JJ cord-028721-x6f26ahr 3430 33 locations location NNS cord-028721-x6f26ahr 3430 34 such such JJ cord-028721-x6f26ahr 3430 35 as as IN cord-028721-x6f26ahr 3430 36 the the DT cord-028721-x6f26ahr 3430 37 perineum perineum NN cord-028721-x6f26ahr 3430 38 , , , cord-028721-x6f26ahr 3430 39 subcutaneous subcutaneous JJ cord-028721-x6f26ahr 3430 40 tissues tissue NNS cord-028721-x6f26ahr 3430 41 , , , cord-028721-x6f26ahr 3430 42 or or CC cord-028721-x6f26ahr 3430 43 superfi superfi NNS cord-028721-x6f26ahr 3430 44 cial cial XX cord-028721-x6f26ahr 3430 45 to to IN cord-028721-x6f26ahr 3430 46 the the DT cord-028721-x6f26ahr 3430 47 outer outer JJ cord-028721-x6f26ahr 3430 48 oblique oblique JJ cord-028721-x6f26ahr 3430 49 fascia fascia NN cord-028721-x6f26ahr 3430 50 . . . cord-028721-x6f26ahr 3431 1 1453 1453 CD cord-028721-x6f26ahr 3431 2 , , , cord-028721-x6f26ahr 3432 1 1454 1454 CD cord-028721-x6f26ahr 3432 2 Spermatogenetic Spermatogenetic NNP cord-028721-x6f26ahr 3432 3 recovery recovery NN cord-028721-x6f26ahr 3432 4 by by IN cord-028721-x6f26ahr 3432 5 orchidopexy orchidopexy NN cord-028721-x6f26ahr 3432 6 has have VBZ cord-028721-x6f26ahr 3432 7 been be VBN cord-028721-x6f26ahr 3432 8 successfully successfully RB cord-028721-x6f26ahr 3432 9 performed perform VBN cord-028721-x6f26ahr 3432 10 up up IN cord-028721-x6f26ahr 3432 11 to to TO cord-028721-x6f26ahr 3432 12 13 13 CD cord-028721-x6f26ahr 3432 13 years year NNS cord-028721-x6f26ahr 3432 14 after after IN cord-028721-x6f26ahr 3432 15 bilateral bilateral JJ cord-028721-x6f26ahr 3432 16 traumatic traumatic JJ cord-028721-x6f26ahr 3432 17 dislocation dislocation NN cord-028721-x6f26ahr 3432 18 . . . cord-028721-x6f26ahr 3433 1 1455 1455 CD cord-028721-x6f26ahr 3433 2 Sexual sexual JJ cord-028721-x6f26ahr 3433 3 dysfunction dysfunction NN cord-028721-x6f26ahr 3433 4 is be VBZ cord-028721-x6f26ahr 3433 5 found find VBN cord-028721-x6f26ahr 3433 6 in in IN cord-028721-x6f26ahr 3433 7 25 25 CD cord-028721-x6f26ahr 3433 8 - - SYM cord-028721-x6f26ahr 3433 9 50 50 CD cord-028721-x6f26ahr 3433 10 % % NN cord-028721-x6f26ahr 3433 11 of of IN cord-028721-x6f26ahr 3433 12 patients patient NNS cord-028721-x6f26ahr 3433 13 who who WP cord-028721-x6f26ahr 3433 14 are be VBP cord-028721-x6f26ahr 3433 15 treated treat VBN cord-028721-x6f26ahr 3433 16 for for IN cord-028721-x6f26ahr 3433 17 cancer cancer NN cord-028721-x6f26ahr 3433 18 . . . cord-028721-x6f26ahr 3434 1 1456 1456 CD cord-028721-x6f26ahr 3434 2 Testicular Testicular NNP cord-028721-x6f26ahr 3434 3 cancer cancer NN cord-028721-x6f26ahr 3434 4 , , , cord-028721-x6f26ahr 3434 5 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 3434 6 's 's POS cord-028721-x6f26ahr 3434 7 disease disease NN cord-028721-x6f26ahr 3434 8 , , , cord-028721-x6f26ahr 3434 9 and and CC cord-028721-x6f26ahr 3434 10 leukemia leukemia NN cord-028721-x6f26ahr 3434 11 are be VBP cord-028721-x6f26ahr 3434 12 the the DT cord-028721-x6f26ahr 3434 13 most most RBS cord-028721-x6f26ahr 3434 14 frequent frequent JJ cord-028721-x6f26ahr 3434 15 malignancies malignancy NNS cord-028721-x6f26ahr 3434 16 during during IN cord-028721-x6f26ahr 3434 17 the the DT cord-028721-x6f26ahr 3434 18 reproductive reproductive JJ cord-028721-x6f26ahr 3434 19 years year NNS cord-028721-x6f26ahr 3434 20 . . . cord-028721-x6f26ahr 3435 1 Therefore therefore RB cord-028721-x6f26ahr 3435 2 , , , cord-028721-x6f26ahr 3435 3 preservation preservation NN cord-028721-x6f26ahr 3435 4 of of IN cord-028721-x6f26ahr 3435 5 fertility fertility NN cord-028721-x6f26ahr 3435 6 requires require VBZ cord-028721-x6f26ahr 3435 7 careful careful JJ cord-028721-x6f26ahr 3435 8 selection selection NN cord-028721-x6f26ahr 3435 9 of of IN cord-028721-x6f26ahr 3435 10 less less RBR cord-028721-x6f26ahr 3435 11 gonadotoxic gonadotoxic JJ cord-028721-x6f26ahr 3435 12 therapeutic therapeutic JJ cord-028721-x6f26ahr 3435 13 regimens regimen NNS cord-028721-x6f26ahr 3435 14 ; ; : cord-028721-x6f26ahr 3435 15 if if IN cord-028721-x6f26ahr 3435 16 paternity paternity NN cord-028721-x6f26ahr 3435 17 is be VBZ cord-028721-x6f26ahr 3435 18 planned plan VBN cord-028721-x6f26ahr 3435 19 , , , cord-028721-x6f26ahr 3435 20 cryopreservation cryopreservation NN cord-028721-x6f26ahr 3435 21 of of IN cord-028721-x6f26ahr 3435 22 semen semen NN cord-028721-x6f26ahr 3435 23 before before IN cord-028721-x6f26ahr 3435 24 treatment treatment NN cord-028721-x6f26ahr 3435 25 may may MD cord-028721-x6f26ahr 3435 26 be be VB cord-028721-x6f26ahr 3435 27 considered consider VBN cord-028721-x6f26ahr 3435 28 . . . cord-028721-x6f26ahr 3436 1 The the DT cord-028721-x6f26ahr 3436 2 most most RBS cord-028721-x6f26ahr 3436 3 destructive destructive JJ cord-028721-x6f26ahr 3436 4 treatments treatment NNS cord-028721-x6f26ahr 3436 5 for for IN cord-028721-x6f26ahr 3436 6 gonadal gonadal JJ cord-028721-x6f26ahr 3436 7 function function NN cord-028721-x6f26ahr 3436 8 are be VBP cord-028721-x6f26ahr 3436 9 radiation radiation NN cord-028721-x6f26ahr 3436 10 therapy therapy NN cord-028721-x6f26ahr 3436 11 and and CC cord-028721-x6f26ahr 3436 12 alkylating alkylating JJ cord-028721-x6f26ahr 3436 13 agents agent NNS cord-028721-x6f26ahr 3436 14 . . . cord-028721-x6f26ahr 3437 1 1457 1457 CD cord-028721-x6f26ahr 3437 2 _SP cord-028721-x6f26ahr 3438 1 The the DT cord-028721-x6f26ahr 3438 2 testicular testicular JJ cord-028721-x6f26ahr 3438 3 parenchyma parenchyma NN cord-028721-x6f26ahr 3438 4 is be VBZ cord-028721-x6f26ahr 3438 5 one one CD cord-028721-x6f26ahr 3438 6 of of IN cord-028721-x6f26ahr 3438 7 the the DT cord-028721-x6f26ahr 3438 8 most most RBS cord-028721-x6f26ahr 3438 9 radiosensitive radiosensitive JJ cord-028721-x6f26ahr 3438 10 tissues tissue NNS cord-028721-x6f26ahr 3438 11 of of IN cord-028721-x6f26ahr 3438 12 the the DT cord-028721-x6f26ahr 3438 13 body body NN cord-028721-x6f26ahr 3438 14 , , , cord-028721-x6f26ahr 3438 15 and and CC cord-028721-x6f26ahr 3438 16 the the DT cord-028721-x6f26ahr 3438 17 germ germ NN cord-028721-x6f26ahr 3438 18 cells cell NNS cord-028721-x6f26ahr 3438 19 are be VBP cord-028721-x6f26ahr 3438 20 the the DT cord-028721-x6f26ahr 3438 21 most most RBS cord-028721-x6f26ahr 3438 22 radiosensitive radiosensitive JJ cord-028721-x6f26ahr 3438 23 cells cell NNS cord-028721-x6f26ahr 3438 24 of of IN cord-028721-x6f26ahr 3438 25 the the DT cord-028721-x6f26ahr 3438 26 testis testis NN cord-028721-x6f26ahr 3438 27 . . . cord-028721-x6f26ahr 3439 1 Experimental experimental JJ cord-028721-x6f26ahr 3439 2 irradiation irradiation NN cord-028721-x6f26ahr 3439 3 of of IN cord-028721-x6f26ahr 3439 4 volunteers volunteer NNS cord-028721-x6f26ahr 3439 5 with with IN cord-028721-x6f26ahr 3439 6 a a DT cord-028721-x6f26ahr 3439 7 single single JJ cord-028721-x6f26ahr 3439 8 dose dose NN cord-028721-x6f26ahr 3439 9 revealed reveal VBD cord-028721-x6f26ahr 3439 10 that that IN cord-028721-x6f26ahr 3439 11 late late JJ cord-028721-x6f26ahr 3439 12 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3439 13 ( ( -LRB- cord-028721-x6f26ahr 3439 14 Ap Ap NNP cord-028721-x6f26ahr 3439 15 and and CC cord-028721-x6f26ahr 3439 16 B B NNP cord-028721-x6f26ahr 3439 17 ) ) -RRB- cord-028721-x6f26ahr 3439 18 are be VBP cord-028721-x6f26ahr 3439 19 more more RBR cord-028721-x6f26ahr 3439 20 radiosensitive radiosensitive JJ cord-028721-x6f26ahr 3439 21 than than IN cord-028721-x6f26ahr 3439 22 early early JJ cord-028721-x6f26ahr 3439 23 ( ( -LRB- cord-028721-x6f26ahr 3439 24 Ad ad NN cord-028721-x6f26ahr 3439 25 ) ) -RRB- cord-028721-x6f26ahr 3439 26 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3439 27 . . . cord-028721-x6f26ahr 3440 1 Ap Ap NNP cord-028721-x6f26ahr 3440 2 and and CC cord-028721-x6f26ahr 3440 3 B B NNP cord-028721-x6f26ahr 3440 4 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3440 5 may may MD cord-028721-x6f26ahr 3440 6 be be VB cord-028721-x6f26ahr 3440 7 destroyed destroy VBN cord-028721-x6f26ahr 3440 8 with with IN cord-028721-x6f26ahr 3440 9 doses dose NNS cord-028721-x6f26ahr 3440 10 as as RB cord-028721-x6f26ahr 3440 11 low low JJ cord-028721-x6f26ahr 3440 12 as as IN cord-028721-x6f26ahr 3440 13 0.3 0.3 CD cord-028721-x6f26ahr 3440 14 Gy Gy NNP cord-028721-x6f26ahr 3440 15 ( ( -LRB- cord-028721-x6f26ahr 3440 16 1 1 CD cord-028721-x6f26ahr 3440 17 Gy gy NN cord-028721-x6f26ahr 3440 18 = = SYM cord-028721-x6f26ahr 3440 19 100 100 CD cord-028721-x6f26ahr 3440 20 rad rad NNP cord-028721-x6f26ahr 3440 21 ) ) -RRB- cord-028721-x6f26ahr 3440 22 , , , cord-028721-x6f26ahr 3440 23 whereas whereas IN cord-028721-x6f26ahr 3440 24 Ad ad NN cord-028721-x6f26ahr 3440 25 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3440 26 tolerate tolerate VBP cord-028721-x6f26ahr 3440 27 doses dose NNS cord-028721-x6f26ahr 3440 28 higher high JJR cord-028721-x6f26ahr 3440 29 than than IN cord-028721-x6f26ahr 3440 30 4 4 CD cord-028721-x6f26ahr 3440 31 Gy Gy NNP cord-028721-x6f26ahr 3440 32 . . . cord-028721-x6f26ahr 3441 1 Type type VB cord-028721-x6f26ahr 3441 2 A a DT cord-028721-x6f26ahr 3441 3 spermatogonia spermatogonia NN cord-028721-x6f26ahr 3441 4 , , , cord-028721-x6f26ahr 3441 5 spermatids spermatid NNS cord-028721-x6f26ahr 3441 6 , , , cord-028721-x6f26ahr 3441 7 and and CC cord-028721-x6f26ahr 3441 8 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3441 9 are be VBP cord-028721-x6f26ahr 3441 10 respectively respectively RB cord-028721-x6f26ahr 3441 11 100 100 CD cord-028721-x6f26ahr 3441 12 , , , cord-028721-x6f26ahr 3441 13 200 200 CD cord-028721-x6f26ahr 3441 14 , , , cord-028721-x6f26ahr 3441 15 and and CC cord-028721-x6f26ahr 3441 16 10 10 CD cord-028721-x6f26ahr 3441 17 000 000 CD cord-028721-x6f26ahr 3441 18 times time NNS cord-028721-x6f26ahr 3441 19 less less RBR cord-028721-x6f26ahr 3441 20 radiosensitive radiosensitive JJ cord-028721-x6f26ahr 3441 21 than than IN cord-028721-x6f26ahr 3441 22 B B NNP cord-028721-x6f26ahr 3441 23 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3441 24 . . . cord-028721-x6f26ahr 3442 1 Doses dose NNS cord-028721-x6f26ahr 3442 2 higher high JJR cord-028721-x6f26ahr 3442 3 than than IN cord-028721-x6f26ahr 3442 4 6 6 CD cord-028721-x6f26ahr 3442 5 Gy Gy NNS cord-028721-x6f26ahr 3442 6 produce produce VB cord-028721-x6f26ahr 3442 7 a a DT cord-028721-x6f26ahr 3442 8 Sertoli Sertoli NNP cord-028721-x6f26ahr 3442 9 cellonly cellonly NN cord-028721-x6f26ahr 3442 10 pattern pattern NN cord-028721-x6f26ahr 3442 11 . . . cord-028721-x6f26ahr 3443 1 Leydig leydig NN cord-028721-x6f26ahr 3443 2 cells cell NNS cord-028721-x6f26ahr 3443 3 tolerate tolerate VBP cord-028721-x6f26ahr 3443 4 up up IN cord-028721-x6f26ahr 3443 5 to to TO cord-028721-x6f26ahr 3443 6 8 8 CD cord-028721-x6f26ahr 3443 7 Gy Gy NNP cord-028721-x6f26ahr 3443 8 and and CC cord-028721-x6f26ahr 3443 9 Sertoli Sertoli NNP cord-028721-x6f26ahr 3443 10 cells cell VBZ cord-028721-x6f26ahr 3443 11 up up IN cord-028721-x6f26ahr 3443 12 to to TO cord-028721-x6f26ahr 3443 13 60 60 CD cord-028721-x6f26ahr 3443 14 Gy Gy NNP cord-028721-x6f26ahr 3443 15 , , , cord-028721-x6f26ahr 3443 16 although although IN cord-028721-x6f26ahr 3443 17 Sertoli Sertoli NNP cord-028721-x6f26ahr 3443 18 cells cell NNS cord-028721-x6f26ahr 3443 19 show show VBP cord-028721-x6f26ahr 3443 20 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 3443 21 alterations alteration NNS cord-028721-x6f26ahr 3443 22 and and CC cord-028721-x6f26ahr 3443 23 increased increase VBN cord-028721-x6f26ahr 3443 24 phagocytosis phagocytosis NN cord-028721-x6f26ahr 3443 25 of of IN cord-028721-x6f26ahr 3443 26 germ germ NN cord-028721-x6f26ahr 3443 27 cell cell NN cord-028721-x6f26ahr 3443 28 remnants remnant NNS cord-028721-x6f26ahr 3443 29 after after IN cord-028721-x6f26ahr 3443 30 low low JJ cord-028721-x6f26ahr 3443 31 doses dose NNS cord-028721-x6f26ahr 3443 32 of of IN cord-028721-x6f26ahr 3443 33 radiation radiation NN cord-028721-x6f26ahr 3443 34 . . . cord-028721-x6f26ahr 3444 1 Even even RB cord-028721-x6f26ahr 3444 2 with with IN cord-028721-x6f26ahr 3444 3 optimal optimal JJ cord-028721-x6f26ahr 3444 4 protection protection NN cord-028721-x6f26ahr 3444 5 , , , cord-028721-x6f26ahr 3444 6 the the DT cord-028721-x6f26ahr 3444 7 contralateral contralateral JJ cord-028721-x6f26ahr 3444 8 testis testis NN cord-028721-x6f26ahr 3444 9 absorbs absorb VBZ cord-028721-x6f26ahr 3444 10 from from IN cord-028721-x6f26ahr 3444 11 0.2 0.2 CD cord-028721-x6f26ahr 3444 12 to to TO cord-028721-x6f26ahr 3444 13 1.4 1.4 CD cord-028721-x6f26ahr 3444 14 Gy gy NN cord-028721-x6f26ahr 3444 15 in in IN cord-028721-x6f26ahr 3444 16 adjuvant adjuvant NN cord-028721-x6f26ahr 3444 17 therapy therapy NN cord-028721-x6f26ahr 3444 18 for for IN cord-028721-x6f26ahr 3444 19 rectal rectal JJ cord-028721-x6f26ahr 3444 20 cancer cancer NN cord-028721-x6f26ahr 3444 21 1458 1458 CD cord-028721-x6f26ahr 3444 22 or or CC cord-028721-x6f26ahr 3444 23 when when WRB cord-028721-x6f26ahr 3444 24 the the DT cord-028721-x6f26ahr 3444 25 opposite opposite JJ cord-028721-x6f26ahr 3444 26 testis testis NN cord-028721-x6f26ahr 3444 27 is be VBZ cord-028721-x6f26ahr 3444 28 irradiated irradiate VBN cord-028721-x6f26ahr 3444 29 , , , cord-028721-x6f26ahr 3444 30 1459 1459 CD cord-028721-x6f26ahr 3444 31 a a DT cord-028721-x6f26ahr 3444 32 dose dose NN cord-028721-x6f26ahr 3444 33 suffi suffi NNP cord-028721-x6f26ahr 3444 34 cient cient NN cord-028721-x6f26ahr 3444 35 to to TO cord-028721-x6f26ahr 3444 36 cause cause VB cord-028721-x6f26ahr 3444 37 temporary temporary JJ cord-028721-x6f26ahr 3444 38 azoospermia azoospermia NN cord-028721-x6f26ahr 3444 39 . . . cord-028721-x6f26ahr 3445 1 Likewise likewise RB cord-028721-x6f26ahr 3445 2 , , , cord-028721-x6f26ahr 3445 3 irradiation irradiation NN cord-028721-x6f26ahr 3445 4 of of IN cord-028721-x6f26ahr 3445 5 iliac iliac JJ cord-028721-x6f26ahr 3445 6 or or CC cord-028721-x6f26ahr 3445 7 inguinal inguinal JJ cord-028721-x6f26ahr 3445 8 lymph lymph NN cord-028721-x6f26ahr 3445 9 nodes node NNS cord-028721-x6f26ahr 3445 10 for for IN cord-028721-x6f26ahr 3445 11 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 3445 12 's 's POS cord-028721-x6f26ahr 3445 13 disease disease NN cord-028721-x6f26ahr 3445 14 or or CC cord-028721-x6f26ahr 3445 15 other other JJ cord-028721-x6f26ahr 3445 16 forms form NNS cord-028721-x6f26ahr 3445 17 of of IN cord-028721-x6f26ahr 3445 18 lymphoma lymphoma NN cord-028721-x6f26ahr 3445 19 exposes expose VBZ cord-028721-x6f26ahr 3445 20 the the DT cord-028721-x6f26ahr 3445 21 testes testis NNS cord-028721-x6f26ahr 3445 22 to to IN cord-028721-x6f26ahr 3445 23 about about RB cord-028721-x6f26ahr 3445 24 5 5 CD cord-028721-x6f26ahr 3445 25 Gy Gy NNP cord-028721-x6f26ahr 3445 26 . . . cord-028721-x6f26ahr 3446 1 1460 1460 CD cord-028721-x6f26ahr 3446 2 Restoration restoration NN cord-028721-x6f26ahr 3446 3 of of IN cord-028721-x6f26ahr 3446 4 testicular testicular JJ cord-028721-x6f26ahr 3446 5 function function NN cord-028721-x6f26ahr 3446 6 is be VBZ cord-028721-x6f26ahr 3446 7 time time NN cord-028721-x6f26ahr 3446 8 - - HYPH cord-028721-x6f26ahr 3446 9 dependent dependent JJ cord-028721-x6f26ahr 3446 10 , , , cord-028721-x6f26ahr 3446 11 1461 1461 CD cord-028721-x6f26ahr 3446 12 requiring require VBG cord-028721-x6f26ahr 3446 13 at at RB cord-028721-x6f26ahr 3446 14 least least JJS cord-028721-x6f26ahr 3446 15 2 2 CD cord-028721-x6f26ahr 3446 16 years year NNS cord-028721-x6f26ahr 3446 17 . . . cord-028721-x6f26ahr 3447 1 1462 1462 CD cord-028721-x6f26ahr 3447 2 Fertility fertility NN cord-028721-x6f26ahr 3447 3 in in IN cord-028721-x6f26ahr 3447 4 thyroid thyroid JJ cord-028721-x6f26ahr 3447 5 cancer cancer NN cord-028721-x6f26ahr 3447 6 patients patient NNS cord-028721-x6f26ahr 3447 7 who who WP cord-028721-x6f26ahr 3447 8 received receive VBD cord-028721-x6f26ahr 3447 9 radioiodine-131 radioiodine-131 NNP cord-028721-x6f26ahr 3447 10 ( ( -LRB- cord-028721-x6f26ahr 3447 11 131 131 CD cord-028721-x6f26ahr 3447 12 I i NN cord-028721-x6f26ahr 3447 13 ) ) -RRB- cord-028721-x6f26ahr 3447 14 therapy therapy NN cord-028721-x6f26ahr 3447 15 decreases decrease VBZ cord-028721-x6f26ahr 3447 16 briefl briefl NNP cord-028721-x6f26ahr 3447 17 y y NNP cord-028721-x6f26ahr 3447 18 , , , cord-028721-x6f26ahr 3447 19 but but CC cord-028721-x6f26ahr 3447 20 infertility infertility NN cord-028721-x6f26ahr 3447 21 is be VBZ cord-028721-x6f26ahr 3447 22 not not RB cord-028721-x6f26ahr 3447 23 permanent permanent JJ cord-028721-x6f26ahr 3447 24 . . . cord-028721-x6f26ahr 3448 1 1463 1463 CD cord-028721-x6f26ahr 3449 1 Electromagnetic electromagnetic JJ cord-028721-x6f26ahr 3449 2 radiation radiation NN cord-028721-x6f26ahr 3449 3 from from IN cord-028721-x6f26ahr 3449 4 cell cell NN cord-028721-x6f26ahr 3449 5 phones phone NNS cord-028721-x6f26ahr 3449 6 impairs impair VBZ cord-028721-x6f26ahr 3449 7 spermatozoon spermatozoon NN cord-028721-x6f26ahr 3449 8 motility motility NN cord-028721-x6f26ahr 3449 9 according accord VBG cord-028721-x6f26ahr 3449 10 to to IN cord-028721-x6f26ahr 3449 11 one one CD cord-028721-x6f26ahr 3449 12 study study NN cord-028721-x6f26ahr 3449 13 . . . cord-028721-x6f26ahr 3450 1 1464 1464 CD cord-028721-x6f26ahr 3451 1 Prepubertal Prepubertal NNP cord-028721-x6f26ahr 3451 2 testes testis NNS cord-028721-x6f26ahr 3451 3 also also RB cord-028721-x6f26ahr 3451 4 are be VBP cord-028721-x6f26ahr 3451 5 sensitive sensitive JJ cord-028721-x6f26ahr 3451 6 to to IN cord-028721-x6f26ahr 3451 7 radiation radiation NN cord-028721-x6f26ahr 3451 8 therapy therapy NN cord-028721-x6f26ahr 3451 9 . . . cord-028721-x6f26ahr 3452 1 Patients patient NNS cord-028721-x6f26ahr 3452 2 treated treat VBN cord-028721-x6f26ahr 3452 3 for for IN cord-028721-x6f26ahr 3452 4 Wilms Wilms NNP cord-028721-x6f26ahr 3452 5 ' ' POS cord-028721-x6f26ahr 3452 6 tumor tumor NN cord-028721-x6f26ahr 3452 7 may may MD cord-028721-x6f26ahr 3452 8 have have VB cord-028721-x6f26ahr 3452 9 delayed delay VBN cord-028721-x6f26ahr 3452 10 puberty puberty NN cord-028721-x6f26ahr 3452 11 and and CC cord-028721-x6f26ahr 3452 12 , , , cord-028721-x6f26ahr 3452 13 at at IN cord-028721-x6f26ahr 3452 14 adulthood adulthood NN cord-028721-x6f26ahr 3452 15 , , , cord-028721-x6f26ahr 3452 16 oligoospermia oligoospermia NN cord-028721-x6f26ahr 3452 17 or or CC cord-028721-x6f26ahr 3452 18 azoospermia azoospermia NN cord-028721-x6f26ahr 3452 19 with with IN cord-028721-x6f26ahr 3452 20 elevated elevated JJ cord-028721-x6f26ahr 3452 21 levels level NNS cord-028721-x6f26ahr 3452 22 of of IN cord-028721-x6f26ahr 3452 23 FSH fsh NN cord-028721-x6f26ahr 3452 24 ; ; : cord-028721-x6f26ahr 3452 25 this this DT cord-028721-x6f26ahr 3452 26 fi fi NN cord-028721-x6f26ahr 3452 27 nding nding NN cord-028721-x6f26ahr 3452 28 suggests suggest VBZ cord-028721-x6f26ahr 3452 29 that that IN cord-028721-x6f26ahr 3452 30 Leydig Leydig NNP cord-028721-x6f26ahr 3452 31 cells cell NNS cord-028721-x6f26ahr 3452 32 are be VBP cord-028721-x6f26ahr 3452 33 also also RB cord-028721-x6f26ahr 3452 34 damaged damage VBN cord-028721-x6f26ahr 3452 35 . . . cord-028721-x6f26ahr 3453 1 A a DT cord-028721-x6f26ahr 3453 2 special special JJ cord-028721-x6f26ahr 3453 3 case case NN cord-028721-x6f26ahr 3453 4 is be VBZ cord-028721-x6f26ahr 3453 5 that that DT cord-028721-x6f26ahr 3453 6 of of IN cord-028721-x6f26ahr 3453 7 children child NNS cord-028721-x6f26ahr 3453 8 with with IN cord-028721-x6f26ahr 3453 9 acute acute JJ cord-028721-x6f26ahr 3453 10 lymphoblastic lymphoblastic JJ cord-028721-x6f26ahr 3453 11 leukemia leukemia NN cord-028721-x6f26ahr 3453 12 involving involve VBG cord-028721-x6f26ahr 3453 13 the the DT cord-028721-x6f26ahr 3453 14 testis testis NN cord-028721-x6f26ahr 3453 15 . . . cord-028721-x6f26ahr 3454 1 Radiotherapy radiotherapy NN cord-028721-x6f26ahr 3454 2 with with IN cord-028721-x6f26ahr 3454 3 doses dose NNS cord-028721-x6f26ahr 3454 4 of of IN cord-028721-x6f26ahr 3454 5 20 20 CD cord-028721-x6f26ahr 3454 6 - - SYM cord-028721-x6f26ahr 3454 7 25 25 CD cord-028721-x6f26ahr 3454 8 Gy Gy NNP cord-028721-x6f26ahr 3454 9 , , , cord-028721-x6f26ahr 3454 10 either either CC cord-028721-x6f26ahr 3454 11 alone alone RB cord-028721-x6f26ahr 3454 12 or or CC cord-028721-x6f26ahr 3454 13 with with IN cord-028721-x6f26ahr 3454 14 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3454 15 , , , cord-028721-x6f26ahr 3454 16 causes cause VBZ cord-028721-x6f26ahr 3454 17 irreversible irreversible JJ cord-028721-x6f26ahr 3454 18 damage damage NN cord-028721-x6f26ahr 3454 19 to to IN cord-028721-x6f26ahr 3454 20 the the DT cord-028721-x6f26ahr 3454 21 seminiferous seminiferous JJ cord-028721-x6f26ahr 3454 22 tubules tubule NNS cord-028721-x6f26ahr 3454 23 and and CC cord-028721-x6f26ahr 3454 24 Leydig Leydig NNP cord-028721-x6f26ahr 3454 25 cells cell NNS cord-028721-x6f26ahr 3454 26 . . . cord-028721-x6f26ahr 3455 1 These these DT cord-028721-x6f26ahr 3455 2 patients patient NNS cord-028721-x6f26ahr 3455 3 develop develop VBP cord-028721-x6f26ahr 3455 4 azoospermia azoospermia NN cord-028721-x6f26ahr 3455 5 and and CC cord-028721-x6f26ahr 3455 6 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 3455 7 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3455 8 with with IN cord-028721-x6f26ahr 3455 9 low low JJ cord-028721-x6f26ahr 3455 10 serum serum NN cord-028721-x6f26ahr 3455 11 testosterone testosterone NN cord-028721-x6f26ahr 3455 12 ( ( -LRB- cord-028721-x6f26ahr 3455 13 Fig Fig NNP cord-028721-x6f26ahr 3455 14 . . . cord-028721-x6f26ahr 3455 15 12 12 CD cord-028721-x6f26ahr 3455 16 - - SYM cord-028721-x6f26ahr 3455 17 154 154 CD cord-028721-x6f26ahr 3455 18 ) ) -RRB- cord-028721-x6f26ahr 3455 19 . . . cord-028721-x6f26ahr 3456 1 Widespread widespread JJ cord-028721-x6f26ahr 3456 2 use use NN cord-028721-x6f26ahr 3456 3 of of IN cord-028721-x6f26ahr 3456 4 cytotoxic cytotoxic JJ cord-028721-x6f26ahr 3456 5 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3456 6 has have VBZ cord-028721-x6f26ahr 3456 7 created create VBN cord-028721-x6f26ahr 3456 8 a a DT cord-028721-x6f26ahr 3456 9 number number NN cord-028721-x6f26ahr 3456 10 of of IN cord-028721-x6f26ahr 3456 11 adverse adverse JJ cord-028721-x6f26ahr 3456 12 side side NN cord-028721-x6f26ahr 3456 13 effects effect NNS cord-028721-x6f26ahr 3456 14 , , , cord-028721-x6f26ahr 3456 15 including include VBG cord-028721-x6f26ahr 3456 16 gonadotoxicity gonadotoxicity NN cord-028721-x6f26ahr 3456 17 . . . cord-028721-x6f26ahr 3457 1 Combination combination NN cord-028721-x6f26ahr 3457 2 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3457 3 makes make VBZ cord-028721-x6f26ahr 3457 4 it -PRON- PRP cord-028721-x6f26ahr 3457 5 diffi diffi JJ cord-028721-x6f26ahr 3457 6 cult cult NN cord-028721-x6f26ahr 3457 7 to to TO cord-028721-x6f26ahr 3457 8 ascertain ascertain VB cord-028721-x6f26ahr 3457 9 which which WDT cord-028721-x6f26ahr 3457 10 specifi specifi NNP cord-028721-x6f26ahr 3457 11 c c NNP cord-028721-x6f26ahr 3457 12 agent agent NN cord-028721-x6f26ahr 3457 13 is be VBZ cord-028721-x6f26ahr 3457 14 responsible responsible JJ cord-028721-x6f26ahr 3457 15 for for IN cord-028721-x6f26ahr 3457 16 azoospermia azoospermia NN cord-028721-x6f26ahr 3457 17 and and CC cord-028721-x6f26ahr 3457 18 Leydig Leydig NNP cord-028721-x6f26ahr 3457 19 cell cell NN cord-028721-x6f26ahr 3457 20 dysfunction dysfunction NN cord-028721-x6f26ahr 3457 21 . . . cord-028721-x6f26ahr 3458 1 Comparative comparative JJ cord-028721-x6f26ahr 3458 2 studies study NNS cord-028721-x6f26ahr 3458 3 of of IN cord-028721-x6f26ahr 3458 4 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3458 5 for for IN cord-028721-x6f26ahr 3458 6 acute acute JJ cord-028721-x6f26ahr 3458 7 lymphoblastic lymphoblastic JJ cord-028721-x6f26ahr 3458 8 leukemia leukemia NN cord-028721-x6f26ahr 3458 9 , , , cord-028721-x6f26ahr 3458 10 1465 1465 CD cord-028721-x6f26ahr 3458 11 extragonadal extragonadal JJ cord-028721-x6f26ahr 3458 12 solid solid JJ cord-028721-x6f26ahr 3458 13 tumors tumor NNS cord-028721-x6f26ahr 3458 14 , , , cord-028721-x6f26ahr 3458 15 1466 1466 CD cord-028721-x6f26ahr 3458 16 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 3458 17 's 's POS cord-028721-x6f26ahr 3458 18 disease disease NN cord-028721-x6f26ahr 3458 19 , , , cord-028721-x6f26ahr 3458 20 1467 1467 CD cord-028721-x6f26ahr 3458 21 Ewing Ewing NNP cord-028721-x6f26ahr 3458 22 's 's POS cord-028721-x6f26ahr 3458 23 sarcoma sarcoma NN cord-028721-x6f26ahr 3458 24 , , , cord-028721-x6f26ahr 3458 25 and and CC cord-028721-x6f26ahr 3458 26 other other JJ cord-028721-x6f26ahr 3458 27 soft soft JJ cord-028721-x6f26ahr 3458 28 tissue tissue NN cord-028721-x6f26ahr 3459 1 sarcomas sarcoma NNS cord-028721-x6f26ahr 3459 2 1468 1468 CD cord-028721-x6f26ahr 3459 3 in in IN cord-028721-x6f26ahr 3459 4 children child NNS cord-028721-x6f26ahr 3459 5 and and CC cord-028721-x6f26ahr 3460 1 pubertal pubertal JJ cord-028721-x6f26ahr 3460 2 boys boy NNS cord-028721-x6f26ahr 3460 3 have have VBP cord-028721-x6f26ahr 3460 4 shown show VBN cord-028721-x6f26ahr 3460 5 that that IN cord-028721-x6f26ahr 3460 6 alkylating alkylating JJ cord-028721-x6f26ahr 3460 7 agents agent NNS cord-028721-x6f26ahr 3460 8 cause cause VBP cord-028721-x6f26ahr 3460 9 the the DT cord-028721-x6f26ahr 3460 10 most most RBS cord-028721-x6f26ahr 3460 11 severe severe JJ cord-028721-x6f26ahr 3460 12 testicular testicular JJ cord-028721-x6f26ahr 3460 13 damage damage NN cord-028721-x6f26ahr 3460 14 . . . cord-028721-x6f26ahr 3461 1 Alkylating alkylate VBG cord-028721-x6f26ahr 3461 2 agents agent NNS cord-028721-x6f26ahr 3461 3 destroy destroy VBP cord-028721-x6f26ahr 3461 4 the the DT cord-028721-x6f26ahr 3461 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 3461 6 tubular tubular JJ cord-028721-x6f26ahr 3461 7 cells cell NNS cord-028721-x6f26ahr 3461 8 and and CC cord-028721-x6f26ahr 3461 9 induce induce VB cord-028721-x6f26ahr 3461 10 tubular tubular JJ cord-028721-x6f26ahr 3461 11 atrophy atrophy NN cord-028721-x6f26ahr 3461 12 , , , cord-028721-x6f26ahr 3461 13 shrinking shrink VBG cord-028721-x6f26ahr 3461 14 the the DT cord-028721-x6f26ahr 3461 15 testis testis NN cord-028721-x6f26ahr 3461 16 and and CC cord-028721-x6f26ahr 3461 17 increasing increase VBG cord-028721-x6f26ahr 3461 18 FSH fsh NN cord-028721-x6f26ahr 3461 19 serum serum NN cord-028721-x6f26ahr 3461 20 concentration concentration NN cord-028721-x6f26ahr 3461 21 . . . cord-028721-x6f26ahr 3462 1 1469 1469 CD cord-028721-x6f26ahr 3463 1 These these DT cord-028721-x6f26ahr 3463 2 agents agent NNS cord-028721-x6f26ahr 3463 3 also also RB cord-028721-x6f26ahr 3463 4 impair impair VBP cord-028721-x6f26ahr 3463 5 Leydig Leydig NNP cord-028721-x6f26ahr 3463 6 cell cell NN cord-028721-x6f26ahr 3463 7 function function NN cord-028721-x6f26ahr 3463 8 , , , cord-028721-x6f26ahr 3463 9 causing cause VBG cord-028721-x6f26ahr 3463 10 low low JJ cord-028721-x6f26ahr 3463 11 testosterone testosterone NN cord-028721-x6f26ahr 3463 12 , , , cord-028721-x6f26ahr 3463 13 normal normal JJ cord-028721-x6f26ahr 3463 14 or or CC cord-028721-x6f26ahr 3463 15 elevated elevated JJ cord-028721-x6f26ahr 3463 16 serum serum NN cord-028721-x6f26ahr 3463 17 levels level NNS cord-028721-x6f26ahr 3463 18 of of IN cord-028721-x6f26ahr 3463 19 LH lh NN cord-028721-x6f26ahr 3463 20 , , , cord-028721-x6f26ahr 3463 21 and and CC cord-028721-x6f26ahr 3463 22 an an DT cord-028721-x6f26ahr 3463 23 exaggerated exaggerated JJ cord-028721-x6f26ahr 3463 24 response response NN cord-028721-x6f26ahr 3463 25 of of IN cord-028721-x6f26ahr 3463 26 LH LH NNP cord-028721-x6f26ahr 3463 27 to to IN cord-028721-x6f26ahr 3463 28 GnRH GnRH NNP cord-028721-x6f26ahr 3463 29 administration administration NN cord-028721-x6f26ahr 3463 30 . . . cord-028721-x6f26ahr 3464 1 1470 1470 CD cord-028721-x6f26ahr 3465 1 Testicular testicular JJ cord-028721-x6f26ahr 3465 2 damage damage NN cord-028721-x6f26ahr 3465 3 may may MD cord-028721-x6f26ahr 3465 4 be be VB cord-028721-x6f26ahr 3465 5 increased increase VBN cord-028721-x6f26ahr 3465 6 by by IN cord-028721-x6f26ahr 3465 7 combination combination NN cord-028721-x6f26ahr 3465 8 with with IN cord-028721-x6f26ahr 3465 9 other other JJ cord-028721-x6f26ahr 3465 10 agents agent NNS cord-028721-x6f26ahr 3465 11 ( ( -LRB- cord-028721-x6f26ahr 3465 12 Fig Fig NNP cord-028721-x6f26ahr 3465 13 . . . cord-028721-x6f26ahr 3465 14 12 12 CD cord-028721-x6f26ahr 3465 15 - - SYM cord-028721-x6f26ahr 3465 16 155 155 CD cord-028721-x6f26ahr 3465 17 ) ) -RRB- cord-028721-x6f26ahr 3465 18 . . . cord-028721-x6f26ahr 3466 1 Cyclophosphamide Cyclophosphamide NNP cord-028721-x6f26ahr 3466 2 appears appear VBZ cord-028721-x6f26ahr 3466 3 to to TO cord-028721-x6f26ahr 3466 4 be be VB cord-028721-x6f26ahr 3466 5 responsible responsible JJ cord-028721-x6f26ahr 3466 6 for for IN cord-028721-x6f26ahr 3466 7 the the DT cord-028721-x6f26ahr 3466 8 greatest great JJS cord-028721-x6f26ahr 3466 9 number number NN cord-028721-x6f26ahr 3466 10 of of IN cord-028721-x6f26ahr 3466 11 permanent permanent JJ cord-028721-x6f26ahr 3466 12 or or CC cord-028721-x6f26ahr 3466 13 temporary temporary JJ cord-028721-x6f26ahr 3466 14 cases case NNS cord-028721-x6f26ahr 3466 15 of of IN cord-028721-x6f26ahr 3466 16 azoospermia azoospermia NN cord-028721-x6f26ahr 3466 17 after after IN cord-028721-x6f26ahr 3466 18 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3466 19 . . . cord-028721-x6f26ahr 3467 1 This this DT cord-028721-x6f26ahr 3467 2 agent agent NN cord-028721-x6f26ahr 3467 3 acts act VBZ cord-028721-x6f26ahr 3467 4 directly directly RB cord-028721-x6f26ahr 3467 5 on on IN cord-028721-x6f26ahr 3467 6 the the DT cord-028721-x6f26ahr 3467 7 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 3467 8 stem stem NN cord-028721-x6f26ahr 3467 9 cells cell NNS cord-028721-x6f26ahr 3467 10 , , , cord-028721-x6f26ahr 3467 11 1468 1468 CD cord-028721-x6f26ahr 3467 12 and and CC cord-028721-x6f26ahr 3467 13 recovery recovery NN cord-028721-x6f26ahr 3467 14 depends depend VBZ cord-028721-x6f26ahr 3467 15 on on IN cord-028721-x6f26ahr 3467 16 the the DT cord-028721-x6f26ahr 3467 17 number number NN cord-028721-x6f26ahr 3467 18 of of IN cord-028721-x6f26ahr 3467 19 surviving survive VBG cord-028721-x6f26ahr 3467 20 cells cell NNS cord-028721-x6f26ahr 3467 21 . . . cord-028721-x6f26ahr 3468 1 In in IN cord-028721-x6f26ahr 3468 2 children child NNS cord-028721-x6f26ahr 3468 3 , , , cord-028721-x6f26ahr 3468 4 cyclophosphamide cyclophosphamide RB cord-028721-x6f26ahr 3468 5 reduces reduce VBZ cord-028721-x6f26ahr 3468 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 3468 7 tubule tubule NNP cord-028721-x6f26ahr 3468 8 diameter diameter NN cord-028721-x6f26ahr 3468 9 and and CC cord-028721-x6f26ahr 3468 10 germ germ NN cord-028721-x6f26ahr 3468 11 cell cell NN cord-028721-x6f26ahr 3468 12 numbers number NNS cord-028721-x6f26ahr 3468 13 ; ; : cord-028721-x6f26ahr 3468 14 in in IN cord-028721-x6f26ahr 3468 15 the the DT cord-028721-x6f26ahr 3468 16 residual residual JJ cord-028721-x6f26ahr 3468 17 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3468 18 nuclei nucleus NNS cord-028721-x6f26ahr 3468 19 are be VBP cord-028721-x6f26ahr 3468 20 enlarged enlarge VBN cord-028721-x6f26ahr 3468 21 . . . cord-028721-x6f26ahr 3469 1 Puberty puberty NN cord-028721-x6f26ahr 3469 2 may may MD cord-028721-x6f26ahr 3469 3 progress progress VB cord-028721-x6f26ahr 3469 4 , , , cord-028721-x6f26ahr 3469 5 even even RB cord-028721-x6f26ahr 3469 6 during during IN cord-028721-x6f26ahr 3469 7 treatment treatment NN cord-028721-x6f26ahr 3469 8 , , , cord-028721-x6f26ahr 3469 9 and and CC cord-028721-x6f26ahr 3469 10 the the DT cord-028721-x6f26ahr 3469 11 adult adult NN cord-028721-x6f26ahr 3469 12 testis testis NN cord-028721-x6f26ahr 3469 13 may may MD cord-028721-x6f26ahr 3469 14 show show VB cord-028721-x6f26ahr 3469 15 a a DT cord-028721-x6f26ahr 3469 16 Sertoli Sertoli NNP cord-028721-x6f26ahr 3469 17 cell cell NN cord-028721-x6f26ahr 3469 18 - - HYPH cord-028721-x6f26ahr 3469 19 only only RB cord-028721-x6f26ahr 3469 20 pattern pattern NN cord-028721-x6f26ahr 3469 21 . . . cord-028721-x6f26ahr 3470 1 1465 1465 CD cord-028721-x6f26ahr 3471 1 In in IN cord-028721-x6f26ahr 3471 2 adults adult NNS cord-028721-x6f26ahr 3471 3 , , , cord-028721-x6f26ahr 3471 4 cyclophosphamide cyclophosphamide JJ cord-028721-x6f26ahr 3471 5 treatment treatment NN cord-028721-x6f26ahr 3471 6 may may MD cord-028721-x6f26ahr 3471 7 cause cause VB cord-028721-x6f26ahr 3471 8 irreversible irreversible JJ cord-028721-x6f26ahr 3471 9 testicular testicular JJ cord-028721-x6f26ahr 3471 10 damage damage NN cord-028721-x6f26ahr 3471 11 . . . cord-028721-x6f26ahr 3472 1 Administered administer VBN cord-028721-x6f26ahr 3472 2 alone alone RB cord-028721-x6f26ahr 3472 3 , , , cord-028721-x6f26ahr 3472 4 a a DT cord-028721-x6f26ahr 3472 5 dose dose NN cord-028721-x6f26ahr 3472 6 of of IN cord-028721-x6f26ahr 3472 7 20 20 CD cord-028721-x6f26ahr 3472 8 000 000 CD cord-028721-x6f26ahr 3472 9 mg mg NNP cord-028721-x6f26ahr 3472 10 / / SYM cord-028721-x6f26ahr 3472 11 m m NNP cord-028721-x6f26ahr 3472 12 2 2 NNP cord-028721-x6f26ahr 3472 13 produces produce VBZ cord-028721-x6f26ahr 3472 14 permanent permanent JJ cord-028721-x6f26ahr 3472 15 azoospermia azoospermia NN cord-028721-x6f26ahr 3472 16 in in IN cord-028721-x6f26ahr 3472 17 50 50 CD cord-028721-x6f26ahr 3472 18 % % NN cord-028721-x6f26ahr 3472 19 of of IN cord-028721-x6f26ahr 3472 20 men man NNS cord-028721-x6f26ahr 3472 21 . . . cord-028721-x6f26ahr 3473 1 If if IN cord-028721-x6f26ahr 3473 2 cyclophosphamide cyclophosphamide RB cord-028721-x6f26ahr 3473 3 is be VBZ cord-028721-x6f26ahr 3473 4 administered administer VBN cord-028721-x6f26ahr 3473 5 with with IN cord-028721-x6f26ahr 3473 6 doxorubicin doxorubicin NN cord-028721-x6f26ahr 3473 7 , , , cord-028721-x6f26ahr 3473 8 vincristine vincristine NN cord-028721-x6f26ahr 3473 9 , , , cord-028721-x6f26ahr 3473 10 dacarbazine dacarbazine NNP cord-028721-x6f26ahr 3473 11 , , , cord-028721-x6f26ahr 3473 12 or or CC cord-028721-x6f26ahr 3473 13 dactinomycin dactinomycin NNS cord-028721-x6f26ahr 3473 14 ( ( -LRB- cord-028721-x6f26ahr 3473 15 drugs drug NNS cord-028721-x6f26ahr 3473 16 that that WDT cord-028721-x6f26ahr 3473 17 alone alone RB cord-028721-x6f26ahr 3473 18 do do VBP cord-028721-x6f26ahr 3473 19 not not RB cord-028721-x6f26ahr 3473 20 cause cause VB cord-028721-x6f26ahr 3473 21 azoospermia azoospermia NN cord-028721-x6f26ahr 3473 22 ) ) -RRB- cord-028721-x6f26ahr 3473 23 , , , cord-028721-x6f26ahr 3473 24 doses dose NNS cord-028721-x6f26ahr 3473 25 of of IN cord-028721-x6f26ahr 3473 26 7500 7500 CD cord-028721-x6f26ahr 3473 27 mg mg NNP cord-028721-x6f26ahr 3473 28 / / SYM cord-028721-x6f26ahr 3473 29 m m NN cord-028721-x6f26ahr 3473 30 2 2 CD cord-028721-x6f26ahr 3473 31 cause cause NN cord-028721-x6f26ahr 3473 32 azoospermia azoospermia NN cord-028721-x6f26ahr 3473 33 in in IN cord-028721-x6f26ahr 3473 34 50 50 CD cord-028721-x6f26ahr 3473 35 % % NN cord-028721-x6f26ahr 3473 36 of of IN cord-028721-x6f26ahr 3473 37 patients patient NNS cord-028721-x6f26ahr 3473 38 . . . cord-028721-x6f26ahr 3474 1 Fludarabine Fludarabine NNP cord-028721-x6f26ahr 3474 2 , , , cord-028721-x6f26ahr 3474 3 used use VBN cord-028721-x6f26ahr 3474 4 for for IN cord-028721-x6f26ahr 3474 5 the the DT cord-028721-x6f26ahr 3474 6 treatment treatment NN cord-028721-x6f26ahr 3474 7 of of IN cord-028721-x6f26ahr 3474 8 chronic chronic JJ cord-028721-x6f26ahr 3474 9 lymphocytic lymphocytic JJ cord-028721-x6f26ahr 3474 10 leukemia leukemia NN cord-028721-x6f26ahr 3474 11 , , , cord-028721-x6f26ahr 3474 12 produces produce VBZ cord-028721-x6f26ahr 3474 13 testicular testicular JJ cord-028721-x6f26ahr 3474 14 damage damage NN cord-028721-x6f26ahr 3474 15 with with IN cord-028721-x6f26ahr 3474 16 diminution diminution NN cord-028721-x6f26ahr 3474 17 of of IN cord-028721-x6f26ahr 3474 18 ejaculate ejaculate NN cord-028721-x6f26ahr 3474 19 volume volume NN cord-028721-x6f26ahr 3474 20 , , , cord-028721-x6f26ahr 3474 21 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3474 22 , , , cord-028721-x6f26ahr 3474 23 increase increase NN cord-028721-x6f26ahr 3474 24 in in IN cord-028721-x6f26ahr 3474 25 serum serum NN cord-028721-x6f26ahr 3474 26 levels level NNS cord-028721-x6f26ahr 3474 27 of of IN cord-028721-x6f26ahr 3474 28 FSH fsh NN cord-028721-x6f26ahr 3474 29 and and CC cord-028721-x6f26ahr 3474 30 LH LH NNP cord-028721-x6f26ahr 3474 31 , , , cord-028721-x6f26ahr 3474 32 and and CC cord-028721-x6f26ahr 3474 33 decreased decrease VBD cord-028721-x6f26ahr 3474 34 testosterone testosterone NN cord-028721-x6f26ahr 3474 35 level level NN cord-028721-x6f26ahr 3474 36 . . . cord-028721-x6f26ahr 3475 1 DNA DNA NNP cord-028721-x6f26ahr 3475 2 in in IN cord-028721-x6f26ahr 3475 3 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3475 4 is be VBZ cord-028721-x6f26ahr 3475 5 markedly markedly RB cord-028721-x6f26ahr 3475 6 abnormal abnormal JJ cord-028721-x6f26ahr 3475 7 , , , cord-028721-x6f26ahr 3475 8 an an DT cord-028721-x6f26ahr 3475 9 effect effect NN cord-028721-x6f26ahr 3475 10 that that WDT cord-028721-x6f26ahr 3475 11 persists persist VBZ cord-028721-x6f26ahr 3475 12 for for IN cord-028721-x6f26ahr 3475 13 several several JJ cord-028721-x6f26ahr 3475 14 months month NNS cord-028721-x6f26ahr 3475 15 . . . cord-028721-x6f26ahr 3476 1 1471 1471 CD cord-028721-x6f26ahr 3476 2 Procarbazine Procarbazine NNP cord-028721-x6f26ahr 3476 3 , , , cord-028721-x6f26ahr 3476 4 used use VBD cord-028721-x6f26ahr 3476 5 to to TO cord-028721-x6f26ahr 3476 6 treat treat VB cord-028721-x6f26ahr 3476 7 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 3476 8 's 's POS cord-028721-x6f26ahr 3476 9 disease disease NN cord-028721-x6f26ahr 3476 10 , , , cord-028721-x6f26ahr 3476 11 causes cause VBZ cord-028721-x6f26ahr 3476 12 permanent permanent JJ cord-028721-x6f26ahr 3476 13 azoospermia azoospermia NN cord-028721-x6f26ahr 3476 14 in in IN cord-028721-x6f26ahr 3476 15 30 30 CD cord-028721-x6f26ahr 3476 16 % % NN cord-028721-x6f26ahr 3476 17 of of IN cord-028721-x6f26ahr 3476 18 patients patient NNS cord-028721-x6f26ahr 3476 19 , , , cord-028721-x6f26ahr 3476 20 even even RB cord-028721-x6f26ahr 3476 21 when when WRB cord-028721-x6f26ahr 3476 22 not not RB cord-028721-x6f26ahr 3476 23 combined combine VBN cord-028721-x6f26ahr 3476 24 with with IN cord-028721-x6f26ahr 3476 25 alkylating alkylating JJ cord-028721-x6f26ahr 3476 26 agents agent NNS cord-028721-x6f26ahr 3476 27 . . . cord-028721-x6f26ahr 3477 1 1472 1472 CD cord-028721-x6f26ahr 3477 2 Patients patient NNS cord-028721-x6f26ahr 3477 3 treated treat VBN cord-028721-x6f26ahr 3477 4 with with IN cord-028721-x6f26ahr 3477 5 a a DT cord-028721-x6f26ahr 3477 6 combination combination NN cord-028721-x6f26ahr 3477 7 of of IN cord-028721-x6f26ahr 3477 8 cyclophosphamide cyclophosphamide NN cord-028721-x6f26ahr 3477 9 and and CC cord-028721-x6f26ahr 3477 10 procarbazine procarbazine NN cord-028721-x6f26ahr 3477 11 in in IN cord-028721-x6f26ahr 3477 12 the the DT cord-028721-x6f26ahr 3477 13 COPP COPP NNP cord-028721-x6f26ahr 3477 14 protocol protocol NN cord-028721-x6f26ahr 3477 15 ( ( -LRB- cord-028721-x6f26ahr 3477 16 cyclophosphamide cyclophosphamide RB cord-028721-x6f26ahr 3477 17 , , , cord-028721-x6f26ahr 3477 18 vincristine vincristine NN cord-028721-x6f26ahr 3477 19 , , , cord-028721-x6f26ahr 3477 20 procarbazine procarbazine NN cord-028721-x6f26ahr 3477 21 , , , cord-028721-x6f26ahr 3477 22 and and CC cord-028721-x6f26ahr 3477 23 prednisone prednisone NNP cord-028721-x6f26ahr 3477 24 ) ) -RRB- cord-028721-x6f26ahr 3477 25 do do VBP cord-028721-x6f26ahr 3477 26 not not RB cord-028721-x6f26ahr 3477 27 recover recover VB cord-028721-x6f26ahr 3477 28 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3477 29 even even RB cord-028721-x6f26ahr 3477 30 if if IN cord-028721-x6f26ahr 3477 31 the the DT cord-028721-x6f26ahr 3477 32 cyclophosphamide cyclophosphamide JJ cord-028721-x6f26ahr 3477 33 dose dose NN cord-028721-x6f26ahr 3477 34 does do VBZ cord-028721-x6f26ahr 3477 35 not not RB cord-028721-x6f26ahr 3477 36 exceed exceed VB cord-028721-x6f26ahr 3477 37 4800 4800 CD cord-028721-x6f26ahr 3477 38 mg mg NNP cord-028721-x6f26ahr 3477 39 / / SYM cord-028721-x6f26ahr 3477 40 m m NN cord-028721-x6f26ahr 3477 41 2 2 CD cord-028721-x6f26ahr 3477 42 . . . cord-028721-x6f26ahr 3478 1 Chemotherapy chemotherapy NN cord-028721-x6f26ahr 3478 2 without without IN cord-028721-x6f26ahr 3478 3 both both DT cord-028721-x6f26ahr 3478 4 alkylating alkylating JJ cord-028721-x6f26ahr 3478 5 agents agent NNS cord-028721-x6f26ahr 3478 6 and and CC cord-028721-x6f26ahr 3478 7 procarbazine procarbazine NN cord-028721-x6f26ahr 3478 8 , , , cord-028721-x6f26ahr 3478 9 such such JJ cord-028721-x6f26ahr 3478 10 as as IN cord-028721-x6f26ahr 3478 11 the the DT cord-028721-x6f26ahr 3478 12 ABVD ABVD NNP cord-028721-x6f26ahr 3478 13 ( ( -LRB- cord-028721-x6f26ahr 3478 14 dexorubicin dexorubicin NNS cord-028721-x6f26ahr 3478 15 , , , cord-028721-x6f26ahr 3478 16 bleomycin bleomycin NN cord-028721-x6f26ahr 3478 17 , , , cord-028721-x6f26ahr 3478 18 vinblastine vinblastine NN cord-028721-x6f26ahr 3478 19 and and CC cord-028721-x6f26ahr 3478 20 dacarbazine dacarbazine NNP cord-028721-x6f26ahr 3478 21 ) ) -RRB- cord-028721-x6f26ahr 3478 22 or or CC cord-028721-x6f26ahr 3478 23 VBM VBM NNP cord-028721-x6f26ahr 3478 24 ( ( -LRB- cord-028721-x6f26ahr 3478 25 vinblastine vinblastine NN cord-028721-x6f26ahr 3478 26 , , , cord-028721-x6f26ahr 3478 27 bleomycin bleomycin NN cord-028721-x6f26ahr 3478 28 and and CC cord-028721-x6f26ahr 3478 29 methotrexate methotrexate NNP cord-028721-x6f26ahr 3478 30 ) ) -RRB- cord-028721-x6f26ahr 3478 31 regimens regimen NNS cord-028721-x6f26ahr 3478 32 , , , cord-028721-x6f26ahr 3478 33 produces produce VBZ cord-028721-x6f26ahr 3478 34 reversible reversible JJ cord-028721-x6f26ahr 3478 35 azoospermia azoospermia NN cord-028721-x6f26ahr 3478 36 in in IN cord-028721-x6f26ahr 3478 37 36 36 CD cord-028721-x6f26ahr 3478 38 % % NN cord-028721-x6f26ahr 3478 39 of of IN cord-028721-x6f26ahr 3478 40 patients patient NNS cord-028721-x6f26ahr 3478 41 . . . cord-028721-x6f26ahr 3479 1 The the DT cord-028721-x6f26ahr 3479 2 alternating alternate VBG cord-028721-x6f26ahr 3479 3 use use NN cord-028721-x6f26ahr 3479 4 of of IN cord-028721-x6f26ahr 3479 5 MOPP MOPP NNP cord-028721-x6f26ahr 3479 6 ( ( -LRB- cord-028721-x6f26ahr 3479 7 mechlorethamine mechlorethamine NN cord-028721-x6f26ahr 3479 8 , , , cord-028721-x6f26ahr 3479 9 vincristine vincristine NN cord-028721-x6f26ahr 3479 10 , , , cord-028721-x6f26ahr 3479 11 procarbazine procarbazine NNP cord-028721-x6f26ahr 3479 12 and and CC cord-028721-x6f26ahr 3479 13 prednisone prednisone NNP cord-028721-x6f26ahr 3479 14 ) ) -RRB- cord-028721-x6f26ahr 3479 15 and and CC cord-028721-x6f26ahr 3479 16 Fig Fig NNP cord-028721-x6f26ahr 3479 17 . . . cord-028721-x6f26ahr 3480 1 12 12 CD cord-028721-x6f26ahr 3480 2 - - SYM cord-028721-x6f26ahr 3480 3 154 154 CD cord-028721-x6f26ahr 3480 4 Testis Testis NNP cord-028721-x6f26ahr 3480 5 from from IN cord-028721-x6f26ahr 3480 6 a a DT cord-028721-x6f26ahr 3480 7 26-year 26-year JJ cord-028721-x6f26ahr 3480 8 - - HYPH cord-028721-x6f26ahr 3480 9 old old JJ cord-028721-x6f26ahr 3480 10 patient patient NN cord-028721-x6f26ahr 3480 11 who who WP cord-028721-x6f26ahr 3480 12 , , , cord-028721-x6f26ahr 3480 13 at at IN cord-028721-x6f26ahr 3480 14 the the DT cord-028721-x6f26ahr 3480 15 age age NN cord-028721-x6f26ahr 3480 16 of of IN cord-028721-x6f26ahr 3480 17 9 9 CD cord-028721-x6f26ahr 3480 18 years year NNS cord-028721-x6f26ahr 3480 19 , , , cord-028721-x6f26ahr 3480 20 underwent undergo VBD cord-028721-x6f26ahr 3480 21 surgery surgery NN cord-028721-x6f26ahr 3480 22 followed follow VBN cord-028721-x6f26ahr 3480 23 by by IN cord-028721-x6f26ahr 3480 24 radiotherapy radiotherapy NNP cord-028721-x6f26ahr 3480 25 for for IN cord-028721-x6f26ahr 3480 26 paratesticular paratesticular NNP cord-028721-x6f26ahr 3480 27 rhabdomyosarcoma rhabdomyosarcoma NNP cord-028721-x6f26ahr 3480 28 . . . cord-028721-x6f26ahr 3481 1 The the DT cord-028721-x6f26ahr 3481 2 testicular testicular JJ cord-028721-x6f26ahr 3481 3 biopsy biopsy NN cord-028721-x6f26ahr 3481 4 shows show VBZ cord-028721-x6f26ahr 3481 5 post post JJ cord-028721-x6f26ahr 3481 6 - - JJ cord-028721-x6f26ahr 3481 7 irradiation irradiation JJ cord-028721-x6f26ahr 3481 8 lesions lesion NNS cord-028721-x6f26ahr 3481 9 , , , cord-028721-x6f26ahr 3481 10 including include VBG cord-028721-x6f26ahr 3481 11 germ germ NN cord-028721-x6f26ahr 3481 12 cell cell NN cord-028721-x6f26ahr 3481 13 aplasia aplasia NNP cord-028721-x6f26ahr 3481 14 and and CC cord-028721-x6f26ahr 3481 15 peritubular peritubular NNP cord-028721-x6f26ahr 3481 16 and and CC cord-028721-x6f26ahr 3481 17 interstitial interstitial JJ cord-028721-x6f26ahr 3481 18 fi fi NN cord-028721-x6f26ahr 3481 19 brosis brosis NN cord-028721-x6f26ahr 3481 20 . . . cord-028721-x6f26ahr 3481 21 _SP cord-028721-x6f26ahr 3482 1 ABVD ABVD NNP cord-028721-x6f26ahr 3482 2 treatments treatment NNS cord-028721-x6f26ahr 3482 3 causes cause VBZ cord-028721-x6f26ahr 3482 4 testicular testicular JJ cord-028721-x6f26ahr 3482 5 dysfunction dysfunction NN cord-028721-x6f26ahr 3482 6 in in IN cord-028721-x6f26ahr 3482 7 87 87 CD cord-028721-x6f26ahr 3482 8 % % NN cord-028721-x6f26ahr 3482 9 of of IN cord-028721-x6f26ahr 3482 10 patients patient NNS cord-028721-x6f26ahr 3482 11 , , , cord-028721-x6f26ahr 3482 12 but but CC cord-028721-x6f26ahr 3482 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3482 14 recovers recover VBZ cord-028721-x6f26ahr 3482 15 in in IN cord-028721-x6f26ahr 3482 16 40 40 CD cord-028721-x6f26ahr 3482 17 % % NN cord-028721-x6f26ahr 3482 18 . . . cord-028721-x6f26ahr 3483 1 1473 1473 CD cord-028721-x6f26ahr 3483 2 Patients patient NNS cord-028721-x6f26ahr 3483 3 with with IN cord-028721-x6f26ahr 3483 4 germ germ NN cord-028721-x6f26ahr 3483 5 cell cell NN cord-028721-x6f26ahr 3483 6 cancer cancer NN cord-028721-x6f26ahr 3483 7 who who WP cord-028721-x6f26ahr 3483 8 received receive VBD cord-028721-x6f26ahr 3483 9 chemotherapy chemotherapy NN cord-028721-x6f26ahr 3483 10 with with IN cord-028721-x6f26ahr 3483 11 BEP BEP NNP cord-028721-x6f26ahr 3483 12 regimens regimen NNS cord-028721-x6f26ahr 3483 13 ( ( -LRB- cord-028721-x6f26ahr 3483 14 cisplatinum cisplatinum NNP cord-028721-x6f26ahr 3483 15 , , , cord-028721-x6f26ahr 3483 16 etoposide etoposide RB cord-028721-x6f26ahr 3483 17 , , , cord-028721-x6f26ahr 3483 18 and and CC cord-028721-x6f26ahr 3483 19 bleomycin bleomycin NN cord-028721-x6f26ahr 3483 20 ) ) -RRB- cord-028721-x6f26ahr 3483 21 become become VBP cord-028721-x6f26ahr 3483 22 azoospermic azoospermic NNP cord-028721-x6f26ahr 3483 23 7 7 CD cord-028721-x6f26ahr 3483 24 - - SYM cord-028721-x6f26ahr 3483 25 8 8 CD cord-028721-x6f26ahr 3483 26 weeks week NNS cord-028721-x6f26ahr 3483 27 after after IN cord-028721-x6f26ahr 3483 28 starting start VBG cord-028721-x6f26ahr 3483 29 treatment treatment NN cord-028721-x6f26ahr 3483 30 . . . cord-028721-x6f26ahr 3484 1 When when WRB cord-028721-x6f26ahr 3484 2 the the DT cord-028721-x6f26ahr 3484 3 total total JJ cord-028721-x6f26ahr 3484 4 doses dose NNS cord-028721-x6f26ahr 3484 5 reaches reach VBZ cord-028721-x6f26ahr 3484 6 600 600 CD cord-028721-x6f26ahr 3484 7 mg mg NNP cord-028721-x6f26ahr 3484 8 / / SYM cord-028721-x6f26ahr 3484 9 m m NNP cord-028721-x6f26ahr 3484 10 2 2 CD cord-028721-x6f26ahr 3484 11 , , , cord-028721-x6f26ahr 3484 12 infertility infertility NN cord-028721-x6f26ahr 3484 13 is be VBZ cord-028721-x6f26ahr 3484 14 irreversible irreversible JJ cord-028721-x6f26ahr 3484 15 ; ; : cord-028721-x6f26ahr 3484 16 at at IN cord-028721-x6f26ahr 3484 17 lower low JJR cord-028721-x6f26ahr 3484 18 dosages dosage NNS cord-028721-x6f26ahr 3484 19 , , , cord-028721-x6f26ahr 3484 20 fertility fertility NN cord-028721-x6f26ahr 3484 21 might may MD cord-028721-x6f26ahr 3484 22 be be VB cord-028721-x6f26ahr 3484 23 recovered recover VBN cord-028721-x6f26ahr 3484 24 over over IN cord-028721-x6f26ahr 3484 25 a a DT cord-028721-x6f26ahr 3484 26 period period NN cord-028721-x6f26ahr 3484 27 of of IN cord-028721-x6f26ahr 3484 28 about about RB cord-028721-x6f26ahr 3484 29 2 2 CD cord-028721-x6f26ahr 3484 30 ( ( -LRB- cord-028721-x6f26ahr 3484 31 50 50 CD cord-028721-x6f26ahr 3484 32 % % NN cord-028721-x6f26ahr 3484 33 of of IN cord-028721-x6f26ahr 3484 34 patients patient NNS cord-028721-x6f26ahr 3484 35 ) ) -RRB- cord-028721-x6f26ahr 3484 36 to to IN cord-028721-x6f26ahr 3484 37 5 5 CD cord-028721-x6f26ahr 3484 38 ( ( -LRB- cord-028721-x6f26ahr 3484 39 80 80 CD cord-028721-x6f26ahr 3484 40 % % NN cord-028721-x6f26ahr 3484 41 ) ) -RRB- cord-028721-x6f26ahr 3484 42 years year NNS cord-028721-x6f26ahr 3484 43 , , , cord-028721-x6f26ahr 3484 44 1474 1474 CD cord-028721-x6f26ahr 3484 45 although although IN cord-028721-x6f26ahr 3484 46 a a DT cord-028721-x6f26ahr 3484 47 high high JJ cord-028721-x6f26ahr 3484 48 percentage percentage NN cord-028721-x6f26ahr 3484 49 of of IN cord-028721-x6f26ahr 3484 50 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3484 51 with with IN cord-028721-x6f26ahr 3484 52 DNA dna NN cord-028721-x6f26ahr 3484 53 abnormalities abnormality NNS cord-028721-x6f26ahr 3484 54 persists persist VBZ cord-028721-x6f26ahr 3484 55 . . . cord-028721-x6f26ahr 3485 1 1475 1475 CD cord-028721-x6f26ahr 3486 1 An an DT cord-028721-x6f26ahr 3486 2 important important JJ cord-028721-x6f26ahr 3486 3 consideration consideration NN cord-028721-x6f26ahr 3486 4 in in IN cord-028721-x6f26ahr 3486 5 patients patient NNS cord-028721-x6f26ahr 3486 6 with with IN cord-028721-x6f26ahr 3486 7 testicular testicular JJ cord-028721-x6f26ahr 3486 8 cancer cancer NN cord-028721-x6f26ahr 3486 9 or or CC cord-028721-x6f26ahr 3486 10 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 3486 11 's 's POS cord-028721-x6f26ahr 3486 12 disease disease NN cord-028721-x6f26ahr 3486 13 is be VBZ cord-028721-x6f26ahr 3486 14 the the DT cord-028721-x6f26ahr 3486 15 existence existence NN cord-028721-x6f26ahr 3486 16 of of IN cord-028721-x6f26ahr 3486 17 testicular testicular JJ cord-028721-x6f26ahr 3486 18 dysfunction dysfunction NN cord-028721-x6f26ahr 3486 19 before before IN cord-028721-x6f26ahr 3486 20 treatment treatment NN cord-028721-x6f26ahr 3486 21 . . . cord-028721-x6f26ahr 3487 1 In in IN cord-028721-x6f26ahr 3487 2 some some DT cord-028721-x6f26ahr 3487 3 series series NN cord-028721-x6f26ahr 3487 4 1476 1476 CD cord-028721-x6f26ahr 3487 5 dysfunction dysfunction NN cord-028721-x6f26ahr 3487 6 is be VBZ cord-028721-x6f26ahr 3487 7 present present JJ cord-028721-x6f26ahr 3487 8 at at IN cord-028721-x6f26ahr 3487 9 diagnosis diagnosis NN cord-028721-x6f26ahr 3487 10 in in IN cord-028721-x6f26ahr 3487 11 more more JJR cord-028721-x6f26ahr 3487 12 than than IN cord-028721-x6f26ahr 3487 13 50 50 CD cord-028721-x6f26ahr 3487 14 % % NN cord-028721-x6f26ahr 3487 15 of of IN cord-028721-x6f26ahr 3487 16 patients patient NNS cord-028721-x6f26ahr 3487 17 ; ; : cord-028721-x6f26ahr 3487 18 its -PRON- PRP$ cord-028721-x6f26ahr 3487 19 cause cause NN cord-028721-x6f26ahr 3487 20 is be VBZ cord-028721-x6f26ahr 3487 21 unknown unknown JJ cord-028721-x6f26ahr 3487 22 . . . cord-028721-x6f26ahr 3488 1 Proposed propose VBN cord-028721-x6f26ahr 3488 2 mechanisms mechanism NNS cord-028721-x6f26ahr 3488 3 include include VBP cord-028721-x6f26ahr 3488 4 primary primary JJ cord-028721-x6f26ahr 3488 5 germ germ NN cord-028721-x6f26ahr 3488 6 cell cell NN cord-028721-x6f26ahr 3488 7 defi defi NNP cord-028721-x6f26ahr 3488 8 ciency ciency NNP cord-028721-x6f26ahr 3488 9 , , , cord-028721-x6f26ahr 3488 10 release release NN cord-028721-x6f26ahr 3488 11 of of IN cord-028721-x6f26ahr 3488 12 toxic toxic JJ cord-028721-x6f26ahr 3488 13 substances substance NNS cord-028721-x6f26ahr 3488 14 by by IN cord-028721-x6f26ahr 3488 15 tumor tumor NN cord-028721-x6f26ahr 3488 16 cells cell NNS cord-028721-x6f26ahr 3488 17 , , , cord-028721-x6f26ahr 3488 18 and and CC cord-028721-x6f26ahr 3488 19 alteration alteration NN cord-028721-x6f26ahr 3488 20 in in IN cord-028721-x6f26ahr 3488 21 the the DT cord-028721-x6f26ahr 3488 22 hypothalamo hypothalamo JJ cord-028721-x6f26ahr 3488 23 - - HYPH cord-028721-x6f26ahr 3488 24 hypophysealtesticular hypophysealtesticular NNP cord-028721-x6f26ahr 3488 25 axis axis NN cord-028721-x6f26ahr 3488 26 . . . cord-028721-x6f26ahr 3489 1 Sexual sexual JJ cord-028721-x6f26ahr 3489 2 function function NN cord-028721-x6f26ahr 3489 3 is be VBZ cord-028721-x6f26ahr 3489 4 often often RB cord-028721-x6f26ahr 3489 5 lost lose VBN cord-028721-x6f26ahr 3489 6 in in IN cord-028721-x6f26ahr 3489 7 patients patient NNS cord-028721-x6f26ahr 3489 8 who who WP cord-028721-x6f26ahr 3489 9 undergo undergo VBP cord-028721-x6f26ahr 3489 10 bilateral bilateral JJ cord-028721-x6f26ahr 3489 11 retroperitoneal retroperitoneal JJ cord-028721-x6f26ahr 3489 12 lymph lymph NN cord-028721-x6f26ahr 3489 13 node node NN cord-028721-x6f26ahr 3489 14 dissection dissection NN cord-028721-x6f26ahr 3489 15 for for IN cord-028721-x6f26ahr 3489 16 nonseminomatous nonseminomatous NNP cord-028721-x6f26ahr 3489 17 testicular testicular NNP cord-028721-x6f26ahr 3489 18 cancer cancer NN cord-028721-x6f26ahr 3489 19 . . . cord-028721-x6f26ahr 3490 1 Up up IN cord-028721-x6f26ahr 3490 2 to to TO cord-028721-x6f26ahr 3490 3 90 90 CD cord-028721-x6f26ahr 3490 4 % % NN cord-028721-x6f26ahr 3490 5 lose lose JJ cord-028721-x6f26ahr 3490 6 antegrade antegrade JJ cord-028721-x6f26ahr 3490 7 ejaculation ejaculation NN cord-028721-x6f26ahr 3490 8 , , , cord-028721-x6f26ahr 3490 9 although although IN cord-028721-x6f26ahr 3490 10 libido libido NN cord-028721-x6f26ahr 3490 11 , , , cord-028721-x6f26ahr 3490 12 erection erection NN cord-028721-x6f26ahr 3490 13 , , , cord-028721-x6f26ahr 3490 14 and and CC cord-028721-x6f26ahr 3490 15 orgasm orgasm NN cord-028721-x6f26ahr 3490 16 are be VBP cord-028721-x6f26ahr 3490 17 normal normal JJ cord-028721-x6f26ahr 3490 18 . . . cord-028721-x6f26ahr 3491 1 Loss loss NN cord-028721-x6f26ahr 3491 2 of of IN cord-028721-x6f26ahr 3491 3 antegrade antegrade JJ cord-028721-x6f26ahr 3491 4 ejaculation ejaculation NN cord-028721-x6f26ahr 3491 5 results result NNS cord-028721-x6f26ahr 3491 6 from from IN cord-028721-x6f26ahr 3491 7 the the DT cord-028721-x6f26ahr 3491 8 removal removal NN cord-028721-x6f26ahr 3491 9 of of IN cord-028721-x6f26ahr 3491 10 or or CC cord-028721-x6f26ahr 3491 11 injury injury NN cord-028721-x6f26ahr 3491 12 to to IN cord-028721-x6f26ahr 3491 13 sympathetic sympathetic JJ cord-028721-x6f26ahr 3491 14 ganglia ganglion NNS cord-028721-x6f26ahr 3491 15 and and CC cord-028721-x6f26ahr 3491 16 the the DT cord-028721-x6f26ahr 3491 17 hypogastric hypogastric JJ cord-028721-x6f26ahr 3491 18 nervous nervous JJ cord-028721-x6f26ahr 3491 19 plexus plexus NN cord-028721-x6f26ahr 3491 20 during during IN cord-028721-x6f26ahr 3491 21 surgery surgery NN cord-028721-x6f26ahr 3491 22 . . . cord-028721-x6f26ahr 3492 1 Unilateral unilateral JJ cord-028721-x6f26ahr 3492 2 surgery surgery NN cord-028721-x6f26ahr 3492 3 , , , cord-028721-x6f26ahr 3492 4 especially especially RB cord-028721-x6f26ahr 3492 5 if if IN cord-028721-x6f26ahr 3492 6 the the DT cord-028721-x6f26ahr 3492 7 left left JJ cord-028721-x6f26ahr 3492 8 side side NN cord-028721-x6f26ahr 3492 9 is be VBZ cord-028721-x6f26ahr 3492 10 not not RB cord-028721-x6f26ahr 3492 11 operated operate VBN cord-028721-x6f26ahr 3492 12 on on IN cord-028721-x6f26ahr 3492 13 , , , cord-028721-x6f26ahr 3492 14 reduces reduce VBZ cord-028721-x6f26ahr 3492 15 this this DT cord-028721-x6f26ahr 3492 16 complication complication NN cord-028721-x6f26ahr 3492 17 . . . cord-028721-x6f26ahr 3493 1 1477 1477 CD cord-028721-x6f26ahr 3493 2 , , , cord-028721-x6f26ahr 3493 3 1478 1478 CD cord-028721-x6f26ahr 3493 4 Hypospermatogenesis Hypospermatogenesis NNP cord-028721-x6f26ahr 3493 5 sometimes sometimes RB cord-028721-x6f26ahr 3493 6 occurs occur VBZ cord-028721-x6f26ahr 3493 7 after after IN cord-028721-x6f26ahr 3493 8 surgery surgery NN cord-028721-x6f26ahr 3493 9 for for IN cord-028721-x6f26ahr 3493 10 rectal rectal JJ cord-028721-x6f26ahr 3493 11 cancer cancer NN cord-028721-x6f26ahr 3493 12 , , , cord-028721-x6f26ahr 3493 13 perhaps perhaps RB cord-028721-x6f26ahr 3493 14 due due IN cord-028721-x6f26ahr 3493 15 to to IN cord-028721-x6f26ahr 3493 16 vascular vascular JJ cord-028721-x6f26ahr 3493 17 compromise compromise NN cord-028721-x6f26ahr 3493 18 . . . cord-028721-x6f26ahr 3494 1 Spinal spinal JJ cord-028721-x6f26ahr 3494 2 cord cord NN cord-028721-x6f26ahr 3494 3 injury injury NN cord-028721-x6f26ahr 3494 4 is be VBZ cord-028721-x6f26ahr 3494 5 a a DT cord-028721-x6f26ahr 3494 6 frequent frequent JJ cord-028721-x6f26ahr 3494 7 fi fi NN cord-028721-x6f26ahr 3494 8 nding nding NN cord-028721-x6f26ahr 3494 9 , , , cord-028721-x6f26ahr 3494 10 with with IN cord-028721-x6f26ahr 3494 11 more more JJR cord-028721-x6f26ahr 3494 12 than than IN cord-028721-x6f26ahr 3494 13 10 10 CD cord-028721-x6f26ahr 3494 14 000 000 CD cord-028721-x6f26ahr 3494 15 cases case NNS cord-028721-x6f26ahr 3494 16 annually annually RB cord-028721-x6f26ahr 3494 17 in in IN cord-028721-x6f26ahr 3494 18 the the DT cord-028721-x6f26ahr 3494 19 US US NNP cord-028721-x6f26ahr 3494 20 , , , cord-028721-x6f26ahr 3494 21 mostly mostly RB cord-028721-x6f26ahr 3494 22 in in IN cord-028721-x6f26ahr 3494 23 young young JJ cord-028721-x6f26ahr 3494 24 adults adult NNS cord-028721-x6f26ahr 3494 25 . . . cord-028721-x6f26ahr 3495 1 1479 1479 CD cord-028721-x6f26ahr 3495 2 Fertility fertility NN cord-028721-x6f26ahr 3495 3 is be VBZ cord-028721-x6f26ahr 3495 4 impaired impair VBN cord-028721-x6f26ahr 3495 5 in in IN cord-028721-x6f26ahr 3495 6 90 90 CD cord-028721-x6f26ahr 3495 7 % % NN cord-028721-x6f26ahr 3495 8 of of IN cord-028721-x6f26ahr 3495 9 males male NNS cord-028721-x6f26ahr 3495 10 with with IN cord-028721-x6f26ahr 3495 11 spinal spinal JJ cord-028721-x6f26ahr 3495 12 cord cord NN cord-028721-x6f26ahr 3495 13 injury injury NN cord-028721-x6f26ahr 3495 14 . . . cord-028721-x6f26ahr 3496 1 The the DT cord-028721-x6f26ahr 3496 2 major major JJ cord-028721-x6f26ahr 3496 3 sexual sexual JJ cord-028721-x6f26ahr 3496 4 dysfunctions dysfunction NNS cord-028721-x6f26ahr 3496 5 in in IN cord-028721-x6f26ahr 3496 6 these these DT cord-028721-x6f26ahr 3496 7 patients patient NNS cord-028721-x6f26ahr 3496 8 are be VBP cord-028721-x6f26ahr 3496 9 the the DT cord-028721-x6f26ahr 3496 10 lack lack NN cord-028721-x6f26ahr 3496 11 of of IN cord-028721-x6f26ahr 3496 12 erection erection NN cord-028721-x6f26ahr 3496 13 and and CC cord-028721-x6f26ahr 3496 14 ejaculation ejaculation NN cord-028721-x6f26ahr 3496 15 and and CC cord-028721-x6f26ahr 3496 16 poor poor JJ cord-028721-x6f26ahr 3496 17 semen semen NN cord-028721-x6f26ahr 3496 18 quality quality NN cord-028721-x6f26ahr 3496 19 . . . cord-028721-x6f26ahr 3497 1 [ [ -LRB- cord-028721-x6f26ahr 3497 2 1480 1480 CD cord-028721-x6f26ahr 3497 3 ] ] -RRB- cord-028721-x6f26ahr 3497 4 [ [ -LRB- cord-028721-x6f26ahr 3497 5 1481 1481 CD cord-028721-x6f26ahr 3497 6 ] ] -RRB- cord-028721-x6f26ahr 3498 1 [ [ -LRB- cord-028721-x6f26ahr 3498 2 1482 1482 CD cord-028721-x6f26ahr 3498 3 ] ] -RRB- cord-028721-x6f26ahr 3499 1 [ [ -LRB- cord-028721-x6f26ahr 3499 2 1483 1483 CD cord-028721-x6f26ahr 3499 3 ] ] -RRB- cord-028721-x6f26ahr 3500 1 [ [ -LRB- cord-028721-x6f26ahr 3500 2 1484 1484 CD cord-028721-x6f26ahr 3500 3 ] ] -RRB- cord-028721-x6f26ahr 3501 1 [ [ -LRB- cord-028721-x6f26ahr 3501 2 1485 1485 CD cord-028721-x6f26ahr 3501 3 ] ] -RRB- cord-028721-x6f26ahr 3502 1 Failure failure NN cord-028721-x6f26ahr 3502 2 of of IN cord-028721-x6f26ahr 3502 3 ejaculation ejaculation NN cord-028721-x6f26ahr 3502 4 occurs occur VBZ cord-028721-x6f26ahr 3502 5 in in IN cord-028721-x6f26ahr 3502 6 95 95 CD cord-028721-x6f26ahr 3502 7 % % NN cord-028721-x6f26ahr 3502 8 of of IN cord-028721-x6f26ahr 3502 9 patients patient NNS cord-028721-x6f26ahr 3502 10 . . . cord-028721-x6f26ahr 3503 1 Semen semen NN cord-028721-x6f26ahr 3503 2 may may MD cord-028721-x6f26ahr 3503 3 be be VB cord-028721-x6f26ahr 3503 4 obtained obtain VBN cord-028721-x6f26ahr 3503 5 by by IN cord-028721-x6f26ahr 3503 6 means mean NNS cord-028721-x6f26ahr 3503 7 of of IN cord-028721-x6f26ahr 3503 8 vibratory vibratory JJ cord-028721-x6f26ahr 3503 9 stimulation stimulation NN cord-028721-x6f26ahr 3503 10 of of IN cord-028721-x6f26ahr 3503 11 the the DT cord-028721-x6f26ahr 3503 12 penis penis NN cord-028721-x6f26ahr 3503 13 or or CC cord-028721-x6f26ahr 3503 14 electroejaculation electroejaculation NN cord-028721-x6f26ahr 3503 15 in in IN cord-028721-x6f26ahr 3503 16 more more JJR cord-028721-x6f26ahr 3503 17 than than IN cord-028721-x6f26ahr 3503 18 90 90 CD cord-028721-x6f26ahr 3503 19 % % NN cord-028721-x6f26ahr 3503 20 , , , cord-028721-x6f26ahr 3503 21 but but CC cord-028721-x6f26ahr 3503 22 its -PRON- PRP$ cord-028721-x6f26ahr 3503 23 quality quality NN cord-028721-x6f26ahr 3503 24 is be VBZ cord-028721-x6f26ahr 3503 25 low low JJ cord-028721-x6f26ahr 3503 26 , , , cord-028721-x6f26ahr 3503 27 with with IN cord-028721-x6f26ahr 3503 28 increased increase VBN cord-028721-x6f26ahr 3503 29 numbers number NNS cord-028721-x6f26ahr 3503 30 of of IN cord-028721-x6f26ahr 3503 31 dead dead JJ cord-028721-x6f26ahr 3503 32 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3503 33 , , , cord-028721-x6f26ahr 3503 34 markedly markedly RB cord-028721-x6f26ahr 3503 35 low low JJ cord-028721-x6f26ahr 3503 36 motility motility NN cord-028721-x6f26ahr 3503 37 , , , cord-028721-x6f26ahr 3503 38 and and CC cord-028721-x6f26ahr 3503 39 reduced reduce VBN cord-028721-x6f26ahr 3503 40 fertilization fertilization NN cord-028721-x6f26ahr 3503 41 rate rate NN cord-028721-x6f26ahr 3503 42 . . . cord-028721-x6f26ahr 3504 1 [ [ -LRB- cord-028721-x6f26ahr 3504 2 1486 1486 CD cord-028721-x6f26ahr 3504 3 ] ] -RRB- cord-028721-x6f26ahr 3505 1 [ [ -LRB- cord-028721-x6f26ahr 3505 2 1487 1487 CD cord-028721-x6f26ahr 3505 3 ] ] -RRB- cord-028721-x6f26ahr 3505 4 [ [ -LRB- cord-028721-x6f26ahr 3505 5 1488 1488 CD cord-028721-x6f26ahr 3505 6 ] ] -RRB- cord-028721-x6f26ahr 3506 1 Possible possible JJ cord-028721-x6f26ahr 3506 2 explanations explanation NNS cord-028721-x6f26ahr 3506 3 include include VBP cord-028721-x6f26ahr 3506 4 genitourinary genitourinary JJ cord-028721-x6f26ahr 3506 5 tract tract JJ cord-028721-x6f26ahr 3506 6 infection infection NN cord-028721-x6f26ahr 3506 7 , , , cord-028721-x6f26ahr 3506 8 endocrine endocrine JJ cord-028721-x6f26ahr 3506 9 anomaly anomaly NN cord-028721-x6f26ahr 3506 10 , , , cord-028721-x6f26ahr 3506 11 and and CC cord-028721-x6f26ahr 3506 12 impaired impair VBN cord-028721-x6f26ahr 3506 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3506 14 . . . cord-028721-x6f26ahr 3507 1 Recurrent recurrent JJ cord-028721-x6f26ahr 3507 2 infection infection NN cord-028721-x6f26ahr 3507 3 occurs occur VBZ cord-028721-x6f26ahr 3507 4 in in IN cord-028721-x6f26ahr 3507 5 60 60 CD cord-028721-x6f26ahr 3507 6 - - SYM cord-028721-x6f26ahr 3507 7 70 70 CD cord-028721-x6f26ahr 3507 8 % % NN cord-028721-x6f26ahr 3507 9 of of IN cord-028721-x6f26ahr 3507 10 patients patient NNS cord-028721-x6f26ahr 3507 11 . . . cord-028721-x6f26ahr 3508 1 Compared compare VBN cord-028721-x6f26ahr 3508 2 to to IN cord-028721-x6f26ahr 3508 3 controls control NNS cord-028721-x6f26ahr 3508 4 , , , cord-028721-x6f26ahr 3508 5 a a DT cord-028721-x6f26ahr 3508 6 signifi signifi NN cord-028721-x6f26ahr 3508 7 ca can MD cord-028721-x6f26ahr 3508 8 nt not RB cord-028721-x6f26ahr 3508 9 increase increase VB cord-028721-x6f26ahr 3508 10 in in IN cord-028721-x6f26ahr 3508 11 the the DT cord-028721-x6f26ahr 3508 12 numbers number NNS cord-028721-x6f26ahr 3508 13 of of IN cord-028721-x6f26ahr 3508 14 neutrophils neutrophil NNS cord-028721-x6f26ahr 3508 15 and and CC cord-028721-x6f26ahr 3508 16 macrophages macrophage NNS cord-028721-x6f26ahr 3508 17 occurs occur VBZ cord-028721-x6f26ahr 3508 18 , , , cord-028721-x6f26ahr 3508 19 with with IN cord-028721-x6f26ahr 3508 20 a a DT cord-028721-x6f26ahr 3508 21 marked marked JJ cord-028721-x6f26ahr 3508 22 increase increase NN cord-028721-x6f26ahr 3508 23 in in IN cord-028721-x6f26ahr 3508 24 the the DT cord-028721-x6f26ahr 3508 25 production production NN cord-028721-x6f26ahr 3508 26 of of IN cord-028721-x6f26ahr 3508 27 reactive reactive JJ cord-028721-x6f26ahr 3508 28 oxygen oxygen NN cord-028721-x6f26ahr 3508 29 species specie NNS cord-028721-x6f26ahr 3508 30 . . . cord-028721-x6f26ahr 3509 1 1489 1489 CD cord-028721-x6f26ahr 3509 2 , , , cord-028721-x6f26ahr 3509 3 1490 1490 CD cord-028721-x6f26ahr 3510 1 This this DT cord-028721-x6f26ahr 3510 2 fi fi IN cord-028721-x6f26ahr 3510 3 nding nding NN cord-028721-x6f26ahr 3510 4 and and CC cord-028721-x6f26ahr 3510 5 the the DT cord-028721-x6f26ahr 3510 6 presence presence NN cord-028721-x6f26ahr 3510 7 of of IN cord-028721-x6f26ahr 3510 8 elevated elevated JJ cord-028721-x6f26ahr 3510 9 cytokine cytokine NN cord-028721-x6f26ahr 3510 10 levels level NNS cord-028721-x6f26ahr 3510 11 1491 1491 CD cord-028721-x6f26ahr 3510 12 are be VBP cord-028721-x6f26ahr 3510 13 assumed assume VBN cord-028721-x6f26ahr 3510 14 to to TO cord-028721-x6f26ahr 3510 15 be be VB cord-028721-x6f26ahr 3510 16 involved involve VBN cord-028721-x6f26ahr 3510 17 in in IN cord-028721-x6f26ahr 3510 18 pathogenesis pathogenesis NN cord-028721-x6f26ahr 3510 19 . . . cord-028721-x6f26ahr 3511 1 Endocrine endocrine JJ cord-028721-x6f26ahr 3511 2 anomalies anomaly NNS cord-028721-x6f26ahr 3511 3 are be VBP cord-028721-x6f26ahr 3511 4 transient transient JJ cord-028721-x6f26ahr 3511 5 , , , cord-028721-x6f26ahr 3511 6 and and CC cord-028721-x6f26ahr 3511 7 hormonal hormonal JJ cord-028721-x6f26ahr 3511 8 levels level NNS cord-028721-x6f26ahr 3511 9 return return VBP cord-028721-x6f26ahr 3511 10 to to IN cord-028721-x6f26ahr 3511 11 normal normal JJ cord-028721-x6f26ahr 3511 12 after after IN cord-028721-x6f26ahr 3511 13 a a DT cord-028721-x6f26ahr 3511 14 few few JJ cord-028721-x6f26ahr 3511 15 months month NNS cord-028721-x6f26ahr 3511 16 . . . cord-028721-x6f26ahr 3512 1 More More JJR cord-028721-x6f26ahr 3512 2 than than IN cord-028721-x6f26ahr 3512 3 50 50 CD cord-028721-x6f26ahr 3512 4 % % NN cord-028721-x6f26ahr 3512 5 of of IN cord-028721-x6f26ahr 3512 6 patients patient NNS cord-028721-x6f26ahr 3512 7 have have VBP cord-028721-x6f26ahr 3512 8 abnormalities abnormality NNS cord-028721-x6f26ahr 3512 9 of of IN cord-028721-x6f26ahr 3512 10 the the DT cord-028721-x6f26ahr 3512 11 adluminal adluminal NNP cord-028721-x6f26ahr 3512 12 compartment compartment NNP cord-028721-x6f26ahr 3512 13 of of IN cord-028721-x6f26ahr 3512 14 the the DT cord-028721-x6f26ahr 3512 15 seminiferous seminiferous JJ cord-028721-x6f26ahr 3512 16 tubules tubule NNS cord-028721-x6f26ahr 3512 17 , , , cord-028721-x6f26ahr 3512 18 with with IN cord-028721-x6f26ahr 3512 19 variable variable JJ cord-028721-x6f26ahr 3512 20 degrees degree NNS cord-028721-x6f26ahr 3512 21 of of IN cord-028721-x6f26ahr 3512 22 immature immature JJ cord-028721-x6f26ahr 3512 23 germ germ NN cord-028721-x6f26ahr 3512 24 cell cell NN cord-028721-x6f26ahr 3512 25 sloughing slough VBG cord-028721-x6f26ahr 3512 26 ; ; : cord-028721-x6f26ahr 3512 27 1482 1482 CD cord-028721-x6f26ahr 3512 28 in in IN cord-028721-x6f26ahr 3512 29 50 50 CD cord-028721-x6f26ahr 3512 30 % % NN cord-028721-x6f26ahr 3512 31 of of IN cord-028721-x6f26ahr 3512 32 patients patient NNS cord-028721-x6f26ahr 3512 33 the the DT cord-028721-x6f26ahr 3512 34 number number NN cord-028721-x6f26ahr 3512 35 of of IN cord-028721-x6f26ahr 3512 36 mature mature JJ cord-028721-x6f26ahr 3512 37 spermatids spermatid NNS cord-028721-x6f26ahr 3512 38 per per IN cord-028721-x6f26ahr 3512 39 cross cross JJ cord-028721-x6f26ahr 3512 40 - - JJ cord-028721-x6f26ahr 3512 41 sectioned sectioned JJ cord-028721-x6f26ahr 3512 42 tubule tubule NN cord-028721-x6f26ahr 3512 43 is be VBZ cord-028721-x6f26ahr 3512 44 less less JJR cord-028721-x6f26ahr 3512 45 than than IN cord-028721-x6f26ahr 3512 46 10 10 CD cord-028721-x6f26ahr 3512 47 ( ( -LRB- cord-028721-x6f26ahr 3512 48 normal normal JJ cord-028721-x6f26ahr 3512 49 > > XX cord-028721-x6f26ahr 3512 50 21 21 CD cord-028721-x6f26ahr 3512 51 ) ) -RRB- cord-028721-x6f26ahr 3512 52 . . . cord-028721-x6f26ahr 3513 1 Possible possible JJ cord-028721-x6f26ahr 3513 2 etiologies etiology NNS cord-028721-x6f26ahr 3513 3 include include VBP cord-028721-x6f26ahr 3513 4 an an DT cord-028721-x6f26ahr 3513 5 increase increase NN cord-028721-x6f26ahr 3513 6 in in IN cord-028721-x6f26ahr 3513 7 testicular testicular JJ cord-028721-x6f26ahr 3513 8 temperature temperature NN cord-028721-x6f26ahr 3513 9 due due IN cord-028721-x6f26ahr 3513 10 to to IN cord-028721-x6f26ahr 3513 11 vascular vascular JJ cord-028721-x6f26ahr 3513 12 dilation dilation NN cord-028721-x6f26ahr 3513 13 , , , cord-028721-x6f26ahr 3513 14 or or CC cord-028721-x6f26ahr 3513 15 an an DT cord-028721-x6f26ahr 3513 16 alteration alteration NN cord-028721-x6f26ahr 3513 17 in in IN cord-028721-x6f26ahr 3513 18 scrotal scrotal JJ cord-028721-x6f26ahr 3513 19 thermoregulation thermoregulation NN cord-028721-x6f26ahr 3513 20 secondary secondary JJ cord-028721-x6f26ahr 3513 21 to to IN cord-028721-x6f26ahr 3513 22 impaired impaired JJ cord-028721-x6f26ahr 3513 23 sympathetic sympathetic JJ cord-028721-x6f26ahr 3513 24 innervation innervation NN cord-028721-x6f26ahr 3513 25 from from IN cord-028721-x6f26ahr 3513 26 prolonged prolong VBN cord-028721-x6f26ahr 3513 27 wheelchair wheelchair NN cord-028721-x6f26ahr 3513 28 restraint restraint NN cord-028721-x6f26ahr 3513 29 ; ; : cord-028721-x6f26ahr 3513 30 alteration alteration NN cord-028721-x6f26ahr 3513 31 in in IN cord-028721-x6f26ahr 3513 32 sperm sperm NN cord-028721-x6f26ahr 3513 33 transport transport NN cord-028721-x6f26ahr 3513 34 secondary secondary JJ cord-028721-x6f26ahr 3513 35 to to IN cord-028721-x6f26ahr 3513 36 nerve nerve NN cord-028721-x6f26ahr 3513 37 injury injury NN cord-028721-x6f26ahr 3513 38 , , , cord-028721-x6f26ahr 3513 39 resulting result VBG cord-028721-x6f26ahr 3513 40 in in IN cord-028721-x6f26ahr 3513 41 sperm sperm NN cord-028721-x6f26ahr 3513 42 stagnation stagnation NN cord-028721-x6f26ahr 3513 43 in in IN cord-028721-x6f26ahr 3513 44 seminal seminal JJ cord-028721-x6f26ahr 3513 45 vesicles vesicle NNS cord-028721-x6f26ahr 3513 46 , , , cord-028721-x6f26ahr 3513 47 a a DT cord-028721-x6f26ahr 3513 48 hostile hostile JJ cord-028721-x6f26ahr 3513 49 environment environment NN cord-028721-x6f26ahr 3513 50 that that WDT cord-028721-x6f26ahr 3513 51 normally normally RB cord-028721-x6f26ahr 3513 52 is be VBZ cord-028721-x6f26ahr 3513 53 devoid devoid JJ cord-028721-x6f26ahr 3513 54 of of IN cord-028721-x6f26ahr 3513 55 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3513 56 ; ; : cord-028721-x6f26ahr 3513 57 1493 1493 CD cord-028721-x6f26ahr 3513 58 and and CC cord-028721-x6f26ahr 3513 59 abnormal abnormal JJ cord-028721-x6f26ahr 3513 60 composition composition NN cord-028721-x6f26ahr 3513 61 of of IN cord-028721-x6f26ahr 3513 62 seminal seminal JJ cord-028721-x6f26ahr 3513 63 fl fl NNP cord-028721-x6f26ahr 3513 64 uid uid NN cord-028721-x6f26ahr 3513 65 , , , cord-028721-x6f26ahr 3513 66 causing cause VBG cord-028721-x6f26ahr 3513 67 deterioration deterioration NN cord-028721-x6f26ahr 3513 68 of of IN cord-028721-x6f26ahr 3513 69 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3513 70 that that IN cord-028721-x6f26ahr 3513 71 in in IN cord-028721-x6f26ahr 3513 72 the the DT cord-028721-x6f26ahr 3513 73 epididymis epididymis NN cord-028721-x6f26ahr 3513 74 and and CC cord-028721-x6f26ahr 3513 75 ductus ductus NN cord-028721-x6f26ahr 3513 76 deferens deferen NNS cord-028721-x6f26ahr 3513 77 had have VBD cord-028721-x6f26ahr 3513 78 good good JJ cord-028721-x6f26ahr 3513 79 motility motility NN cord-028721-x6f26ahr 3513 80 . . . cord-028721-x6f26ahr 3514 1 1494 1494 CD cord-028721-x6f26ahr 3515 1 More More JJR cord-028721-x6f26ahr 3515 2 than than IN cord-028721-x6f26ahr 3515 3 25 25 CD cord-028721-x6f26ahr 3515 4 % % NN cord-028721-x6f26ahr 3515 5 of of IN cord-028721-x6f26ahr 3515 6 patients patient NNS cord-028721-x6f26ahr 3515 7 with with IN cord-028721-x6f26ahr 3515 8 spinal spinal JJ cord-028721-x6f26ahr 3515 9 cord cord NN cord-028721-x6f26ahr 3515 10 injury injury NN cord-028721-x6f26ahr 3515 11 have have VBP cord-028721-x6f26ahr 3515 12 brown brown NN cord-028721-x6f26ahr 3515 13 - - HYPH cord-028721-x6f26ahr 3515 14 tinged tinge VBN cord-028721-x6f26ahr 3515 15 semen semen NN cord-028721-x6f26ahr 3515 16 in in IN cord-028721-x6f26ahr 3515 17 some some DT cord-028721-x6f26ahr 3515 18 ejaculations ejaculation NNS cord-028721-x6f26ahr 3515 19 . . . cord-028721-x6f26ahr 3516 1 1495 1495 CD cord-028721-x6f26ahr 3517 1 Although although IN cord-028721-x6f26ahr 3517 2 the the DT cord-028721-x6f26ahr 3517 3 cause cause NN cord-028721-x6f26ahr 3517 4 is be VBZ cord-028721-x6f26ahr 3517 5 unknown unknown JJ cord-028721-x6f26ahr 3517 6 , , , cord-028721-x6f26ahr 3517 7 it -PRON- PRP cord-028721-x6f26ahr 3517 8 might may MD cord-028721-x6f26ahr 3517 9 be be VB cord-028721-x6f26ahr 3517 10 related relate VBN cord-028721-x6f26ahr 3517 11 to to IN cord-028721-x6f26ahr 3517 12 seminal seminal JJ cord-028721-x6f26ahr 3517 13 vesicle vesicle NN cord-028721-x6f26ahr 3517 14 dysfunction dysfunction NN cord-028721-x6f26ahr 3517 15 . . . cord-028721-x6f26ahr 3518 1 When when WRB cord-028721-x6f26ahr 3518 2 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3518 3 can can MD cord-028721-x6f26ahr 3518 4 not not RB cord-028721-x6f26ahr 3518 5 be be VB cord-028721-x6f26ahr 3518 6 obtained obtain VBN cord-028721-x6f26ahr 3518 7 by by IN cord-028721-x6f26ahr 3518 8 electroejaculation electroejaculation NN cord-028721-x6f26ahr 3518 9 or or CC cord-028721-x6f26ahr 3518 10 vibratory vibratory JJ cord-028721-x6f26ahr 3518 11 stimulation stimulation NN cord-028721-x6f26ahr 3518 12 , , , cord-028721-x6f26ahr 3518 13 vasal vasal JJ cord-028721-x6f26ahr 3518 14 aspiration aspiration NN cord-028721-x6f26ahr 3518 15 or or CC cord-028721-x6f26ahr 3518 16 testicular testicular JJ cord-028721-x6f26ahr 3518 17 biopsy biopsy NN cord-028721-x6f26ahr 3518 18 are be VBP cord-028721-x6f26ahr 3518 19 recommended recommend VBN cord-028721-x6f26ahr 3518 20 . . . cord-028721-x6f26ahr 3519 1 Most Most JJS cord-028721-x6f26ahr 3519 2 patients patient NNS cord-028721-x6f26ahr 3519 3 have have VBP cord-028721-x6f26ahr 3519 4 at at IN cord-028721-x6f26ahr 3519 5 least least JJS cord-028721-x6f26ahr 3519 6 a a DT cord-028721-x6f26ahr 3519 7 few few JJ cord-028721-x6f26ahr 3519 8 mature mature JJ cord-028721-x6f26ahr 3519 9 spermatids spermatid NNS cord-028721-x6f26ahr 3519 10 in in IN cord-028721-x6f26ahr 3519 11 some some DT cord-028721-x6f26ahr 3519 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 3519 13 tubules tubule NNS cord-028721-x6f26ahr 3519 14 ; ; : cord-028721-x6f26ahr 3519 15 therefore therefore RB cord-028721-x6f26ahr 3519 16 , , , cord-028721-x6f26ahr 3519 17 testicular testicular JJ cord-028721-x6f26ahr 3519 18 sperm sperm NN cord-028721-x6f26ahr 3519 19 extraction extraction NN cord-028721-x6f26ahr 3519 20 followed follow VBN cord-028721-x6f26ahr 3519 21 by by IN cord-028721-x6f26ahr 3519 22 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 3519 23 sperm sperm NN cord-028721-x6f26ahr 3519 24 injection injection NN cord-028721-x6f26ahr 3519 25 is be VBZ cord-028721-x6f26ahr 3519 26 a a DT cord-028721-x6f26ahr 3519 27 reasonable reasonable JJ cord-028721-x6f26ahr 3519 28 consideration consideration NN cord-028721-x6f26ahr 3519 29 in in IN cord-028721-x6f26ahr 3519 30 azoospermic azoospermic NNP cord-028721-x6f26ahr 3519 31 patients patient NNS cord-028721-x6f26ahr 3519 32 . . . cord-028721-x6f26ahr 3520 1 1492 1492 CD cord-028721-x6f26ahr 3520 2 Infectious infectious JJ cord-028721-x6f26ahr 3520 3 agents agent NNS cord-028721-x6f26ahr 3520 4 may may MD cord-028721-x6f26ahr 3520 5 reach reach VB cord-028721-x6f26ahr 3520 6 the the DT cord-028721-x6f26ahr 3520 7 testis testis NN cord-028721-x6f26ahr 3520 8 and and CC cord-028721-x6f26ahr 3520 9 epididymis epididymis NN cord-028721-x6f26ahr 3520 10 through through IN cord-028721-x6f26ahr 3520 11 blood blood NN cord-028721-x6f26ahr 3520 12 vessels vessel NNS cord-028721-x6f26ahr 3520 13 , , , cord-028721-x6f26ahr 3520 14 lymphatics lymphatic NNS cord-028721-x6f26ahr 3520 15 , , , cord-028721-x6f26ahr 3520 16 sperm sperm NN cord-028721-x6f26ahr 3520 17 excretory excretory JJ cord-028721-x6f26ahr 3520 18 ducts duct NNS cord-028721-x6f26ahr 3520 19 , , , cord-028721-x6f26ahr 3520 20 or or CC cord-028721-x6f26ahr 3520 21 directly directly RB cord-028721-x6f26ahr 3520 22 from from IN cord-028721-x6f26ahr 3520 23 a a DT cord-028721-x6f26ahr 3520 24 superfi superfi NNS cord-028721-x6f26ahr 3520 25 cial cial NN cord-028721-x6f26ahr 3520 26 wound wound NN cord-028721-x6f26ahr 3520 27 . . . cord-028721-x6f26ahr 3521 1 Infection infection NN cord-028721-x6f26ahr 3521 2 transmitted transmit VBN cord-028721-x6f26ahr 3521 3 through through IN cord-028721-x6f26ahr 3521 4 the the DT cord-028721-x6f26ahr 3521 5 blood blood NN cord-028721-x6f26ahr 3521 6 mainly mainly RB cord-028721-x6f26ahr 3521 7 affects affect VBZ cord-028721-x6f26ahr 3521 8 the the DT cord-028721-x6f26ahr 3521 9 testis testis NN cord-028721-x6f26ahr 3521 10 and and CC cord-028721-x6f26ahr 3521 11 causes cause VBZ cord-028721-x6f26ahr 3521 12 orchitis orchiti NNS cord-028721-x6f26ahr 3521 13 , , , cord-028721-x6f26ahr 3521 14 whereas whereas IN cord-028721-x6f26ahr 3521 15 infection infection NN cord-028721-x6f26ahr 3521 16 ascending ascend VBG cord-028721-x6f26ahr 3521 17 through through IN cord-028721-x6f26ahr 3521 18 the the DT cord-028721-x6f26ahr 3521 19 sperm sperm NN cord-028721-x6f26ahr 3521 20 excretory excretory JJ cord-028721-x6f26ahr 3521 21 ducts duct NNS cord-028721-x6f26ahr 3521 22 usually usually RB cord-028721-x6f26ahr 3521 23 causes cause VBZ cord-028721-x6f26ahr 3521 24 epididymitis epididymitis NN cord-028721-x6f26ahr 3521 25 . . . cord-028721-x6f26ahr 3522 1 Acute acute JJ cord-028721-x6f26ahr 3522 2 infl infl NN cord-028721-x6f26ahr 3522 3 ammation ammation NN cord-028721-x6f26ahr 3522 4 is be VBZ cord-028721-x6f26ahr 3522 5 accompanied accompany VBN cord-028721-x6f26ahr 3522 6 by by IN cord-028721-x6f26ahr 3522 7 enlargement enlargement NN cord-028721-x6f26ahr 3522 8 of of IN cord-028721-x6f26ahr 3522 9 the the DT cord-028721-x6f26ahr 3522 10 testis testis NN cord-028721-x6f26ahr 3522 11 or or CC cord-028721-x6f26ahr 3522 12 epididymis epididymis NN cord-028721-x6f26ahr 3522 13 . . . cord-028721-x6f26ahr 3523 1 The the DT cord-028721-x6f26ahr 3523 2 tunica tunica NNP cord-028721-x6f26ahr 3523 3 albuginea albuginea NNP cord-028721-x6f26ahr 3523 4 is be VBZ cord-028721-x6f26ahr 3523 5 covered cover VBN cord-028721-x6f26ahr 3523 6 by by IN cord-028721-x6f26ahr 3523 7 a a DT cord-028721-x6f26ahr 3523 8 fi fi NNP cord-028721-x6f26ahr 3523 9 brinous brinous JJ cord-028721-x6f26ahr 3523 10 exudate exudate NN cord-028721-x6f26ahr 3523 11 , , , cord-028721-x6f26ahr 3523 12 and and CC cord-028721-x6f26ahr 3523 13 the the DT cord-028721-x6f26ahr 3523 14 testicular testicular JJ cord-028721-x6f26ahr 3523 15 parenchyma parenchyma NN cord-028721-x6f26ahr 3523 16 is be VBZ cord-028721-x6f26ahr 3523 17 yellow yellow JJ cord-028721-x6f26ahr 3523 18 or or CC cord-028721-x6f26ahr 3523 19 brown brown JJ cord-028721-x6f26ahr 3523 20 . . . cord-028721-x6f26ahr 3524 1 Bacterial bacterial JJ cord-028721-x6f26ahr 3524 2 infection infection NN cord-028721-x6f26ahr 3524 3 may may MD cord-028721-x6f26ahr 3524 4 cause cause VB cord-028721-x6f26ahr 3524 5 abscess abscess NN cord-028721-x6f26ahr 3524 6 . . . cord-028721-x6f26ahr 3525 1 In in IN cord-028721-x6f26ahr 3525 2 some some DT cord-028721-x6f26ahr 3525 3 cases case NNS cord-028721-x6f26ahr 3525 4 the the DT cord-028721-x6f26ahr 3525 5 infection infection NN cord-028721-x6f26ahr 3525 6 begins begin VBZ cord-028721-x6f26ahr 3525 7 to to TO cord-028721-x6f26ahr 3525 8 heal heal VB cord-028721-x6f26ahr 3525 9 , , , cord-028721-x6f26ahr 3525 10 with with IN cord-028721-x6f26ahr 3525 11 the the DT cord-028721-x6f26ahr 3525 12 deposition deposition NN cord-028721-x6f26ahr 3525 13 of of IN cord-028721-x6f26ahr 3525 14 granulation granulation NN cord-028721-x6f26ahr 3525 15 tissue tissue NN cord-028721-x6f26ahr 3525 16 and and CC cord-028721-x6f26ahr 3525 17 fi fi NN cord-028721-x6f26ahr 3525 18 brosis brosis NN cord-028721-x6f26ahr 3525 19 ; ; : cord-028721-x6f26ahr 3525 20 in in IN cord-028721-x6f26ahr 3525 21 others other NNS cord-028721-x6f26ahr 3525 22 , , , cord-028721-x6f26ahr 3525 23 the the DT cord-028721-x6f26ahr 3525 24 infection infection NN cord-028721-x6f26ahr 3525 25 may may MD cord-028721-x6f26ahr 3525 26 persist persist VB cord-028721-x6f26ahr 3525 27 as as IN cord-028721-x6f26ahr 3525 28 an an DT cord-028721-x6f26ahr 3525 29 active active JJ cord-028721-x6f26ahr 3525 30 process process NN cord-028721-x6f26ahr 3525 31 for for IN cord-028721-x6f26ahr 3525 32 a a DT cord-028721-x6f26ahr 3525 33 long long JJ cord-028721-x6f26ahr 3525 34 time time NN cord-028721-x6f26ahr 3525 35 , , , cord-028721-x6f26ahr 3525 36 resulting result VBG cord-028721-x6f26ahr 3525 37 in in IN cord-028721-x6f26ahr 3525 38 chronic chronic JJ cord-028721-x6f26ahr 3525 39 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3525 40 . . . cord-028721-x6f26ahr 3526 1 The the DT cord-028721-x6f26ahr 3526 2 most most RBS cord-028721-x6f26ahr 3526 3 frequent frequent JJ cord-028721-x6f26ahr 3526 4 causes cause NNS cord-028721-x6f26ahr 3526 5 of of IN cord-028721-x6f26ahr 3526 6 viral viral JJ cord-028721-x6f26ahr 3526 7 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3526 8 are be VBP cord-028721-x6f26ahr 3526 9 mumps mumps NN cord-028721-x6f26ahr 3526 10 virus virus NN cord-028721-x6f26ahr 3526 11 and and CC cord-028721-x6f26ahr 3526 12 Coxsackie Coxsackie NNP cord-028721-x6f26ahr 3526 13 B B NNP cord-028721-x6f26ahr 3526 14 virus virus NN cord-028721-x6f26ahr 3526 15 . . . cord-028721-x6f26ahr 3527 1 Other other JJ cord-028721-x6f26ahr 3527 2 viral viral JJ cord-028721-x6f26ahr 3527 3 infections infection NNS cord-028721-x6f26ahr 3527 4 that that WDT cord-028721-x6f26ahr 3527 5 occasionally occasionally RB cord-028721-x6f26ahr 3527 6 cause cause VBP cord-028721-x6f26ahr 3527 7 acute acute JJ cord-028721-x6f26ahr 3527 8 orchitis orchiti NNS cord-028721-x6f26ahr 3527 9 include include VBP cord-028721-x6f26ahr 3527 10 infl infl NN cord-028721-x6f26ahr 3527 11 uenza uenza NNP cord-028721-x6f26ahr 3527 12 , , , cord-028721-x6f26ahr 3527 13 infectious infectious JJ cord-028721-x6f26ahr 3527 14 mononucleosis mononucleosis NN cord-028721-x6f26ahr 3527 15 , , , cord-028721-x6f26ahr 3527 16 echovirus echovirus NNP cord-028721-x6f26ahr 3527 17 , , , cord-028721-x6f26ahr 3527 18 lymphocytic lymphocytic JJ cord-028721-x6f26ahr 3527 19 choriomeningitis choriomeningitis NNP cord-028721-x6f26ahr 3527 20 , , , cord-028721-x6f26ahr 3527 21 adenovirus adenovirus NN cord-028721-x6f26ahr 3527 22 , , , cord-028721-x6f26ahr 3527 23 coronavirus coronavirus NN cord-028721-x6f26ahr 3527 24 , , , cord-028721-x6f26ahr 3527 25 bat bat NN cord-028721-x6f26ahr 3527 26 salivary salivary NN cord-028721-x6f26ahr 3527 27 gland gland NN cord-028721-x6f26ahr 3527 28 virus virus NN cord-028721-x6f26ahr 3527 29 , , , cord-028721-x6f26ahr 3527 30 smallpox smallpox NN cord-028721-x6f26ahr 3527 31 , , , cord-028721-x6f26ahr 3527 32 varicella varicella NN cord-028721-x6f26ahr 3527 33 , , , cord-028721-x6f26ahr 3527 34 vaccinia vaccinia NN cord-028721-x6f26ahr 3527 35 , , , cord-028721-x6f26ahr 3527 36 rubella rubella NN cord-028721-x6f26ahr 3527 37 , , , cord-028721-x6f26ahr 3527 38 dengue dengue NN cord-028721-x6f26ahr 3527 39 , , , cord-028721-x6f26ahr 3527 40 and and CC cord-028721-x6f26ahr 3527 41 phlebotomous phlebotomous JJ cord-028721-x6f26ahr 3527 42 fever fever NN cord-028721-x6f26ahr 3527 43 . . . cord-028721-x6f26ahr 3528 1 Subclinical Subclinical NNP cord-028721-x6f26ahr 3528 2 orchitis orchitis NN cord-028721-x6f26ahr 3528 3 probably probably RB cord-028721-x6f26ahr 3528 4 occurs occur VBZ cord-028721-x6f26ahr 3528 5 during during IN cord-028721-x6f26ahr 3528 6 other other JJ cord-028721-x6f26ahr 3528 7 viral viral JJ cord-028721-x6f26ahr 3528 8 infections infection NNS cord-028721-x6f26ahr 3528 9 ( ( -LRB- cord-028721-x6f26ahr 3528 10 Fig Fig NNP cord-028721-x6f26ahr 3528 11 . . . cord-028721-x6f26ahr 3528 12 12 12 CD cord-028721-x6f26ahr 3528 13 - - SYM cord-028721-x6f26ahr 3528 14 156 156 CD cord-028721-x6f26ahr 3528 15 ) ) -RRB- cord-028721-x6f26ahr 3528 16 . . . cord-028721-x6f26ahr 3529 1 Before before IN cord-028721-x6f26ahr 3529 2 vaccination vaccination NN cord-028721-x6f26ahr 3529 3 was be VBD cord-028721-x6f26ahr 3529 4 commonly commonly RB cord-028721-x6f26ahr 3529 5 used use VBN cord-028721-x6f26ahr 3529 6 , , , cord-028721-x6f26ahr 3529 7 mumps mumps NNP cord-028721-x6f26ahr 3529 8 orchidoepididymitis orchidoepididymitis NNP cord-028721-x6f26ahr 3529 9 complicated complicate VBD cord-028721-x6f26ahr 3529 10 14 14 CD cord-028721-x6f26ahr 3529 11 - - SYM cord-028721-x6f26ahr 3529 12 35 35 CD cord-028721-x6f26ahr 3529 13 % % NN cord-028721-x6f26ahr 3529 14 of of IN cord-028721-x6f26ahr 3529 15 adult adult NN cord-028721-x6f26ahr 3529 16 mumps mumps NN cord-028721-x6f26ahr 3529 17 cases case NNS cord-028721-x6f26ahr 3529 18 and and CC cord-028721-x6f26ahr 3529 19 was be VBD cord-028721-x6f26ahr 3529 20 bilateral bilateral JJ cord-028721-x6f26ahr 3529 21 in in IN cord-028721-x6f26ahr 3529 22 20 20 CD cord-028721-x6f26ahr 3529 23 - - SYM cord-028721-x6f26ahr 3529 24 25 25 CD cord-028721-x6f26ahr 3529 25 % % NN cord-028721-x6f26ahr 3529 26 of of IN cord-028721-x6f26ahr 3529 27 cases case NNS cord-028721-x6f26ahr 3529 28 . . . cord-028721-x6f26ahr 3530 1 Nevertheless nevertheless RB cord-028721-x6f26ahr 3530 2 , , , cord-028721-x6f26ahr 3530 3 miniepidemics miniepidemics NNP cord-028721-x6f26ahr 3530 4 still still RB cord-028721-x6f26ahr 3530 5 occasionally occasionally RB cord-028721-x6f26ahr 3530 6 occur occur VBP cord-028721-x6f26ahr 3530 7 . . . cord-028721-x6f26ahr 3531 1 1496 1496 CD cord-028721-x6f26ahr 3531 2 , , , cord-028721-x6f26ahr 3531 3 1497 1497 CD cord-028721-x6f26ahr 3532 1 As as IN cord-028721-x6f26ahr 3532 2 expected expect VBN cord-028721-x6f26ahr 3532 3 , , , cord-028721-x6f26ahr 3532 4 the the DT cord-028721-x6f26ahr 3532 5 incidence incidence NN cord-028721-x6f26ahr 3532 6 remains remain VBZ cord-028721-x6f26ahr 3532 7 high high JJ cord-028721-x6f26ahr 3532 8 in in IN cord-028721-x6f26ahr 3532 9 countries country NNS cord-028721-x6f26ahr 3532 10 where where WRB cord-028721-x6f26ahr 3532 11 vaccination vaccination NN cord-028721-x6f26ahr 3532 12 is be VBZ cord-028721-x6f26ahr 3532 13 not not RB cord-028721-x6f26ahr 3532 14 obligatory obligatory JJ cord-028721-x6f26ahr 3532 15 . . . cord-028721-x6f26ahr 3533 1 1498 1498 CD cord-028721-x6f26ahr 3534 1 In in IN cord-028721-x6f26ahr 3534 2 about about RB cord-028721-x6f26ahr 3534 3 85 85 CD cord-028721-x6f26ahr 3534 4 % % NN cord-028721-x6f26ahr 3534 5 of of IN cord-028721-x6f26ahr 3534 6 cases case NNS cord-028721-x6f26ahr 3534 7 of of IN cord-028721-x6f26ahr 3534 8 mumps mumps NN cord-028721-x6f26ahr 3534 9 orchitis orchitis NN cord-028721-x6f26ahr 3535 1 the the DT cord-028721-x6f26ahr 3535 2 epididymis epididymis NN cord-028721-x6f26ahr 3535 3 is be VBZ cord-028721-x6f26ahr 3535 4 also also RB cord-028721-x6f26ahr 3535 5 involved involve VBN cord-028721-x6f26ahr 3535 6 , , , cord-028721-x6f26ahr 3535 7 but but CC cord-028721-x6f26ahr 3535 8 epididymal epididymal JJ cord-028721-x6f26ahr 3535 9 involvement involvement NN cord-028721-x6f26ahr 3535 10 alone alone RB cord-028721-x6f26ahr 3535 11 is be VBZ cord-028721-x6f26ahr 3535 12 rare rare JJ cord-028721-x6f26ahr 3535 13 . . . cord-028721-x6f26ahr 3536 1 1499 1499 CD cord-028721-x6f26ahr 3537 1 Clinical clinical JJ cord-028721-x6f26ahr 3537 2 symptoms symptom NNS cord-028721-x6f26ahr 3537 3 of of IN cord-028721-x6f26ahr 3537 4 orchitis orchitis NN cord-028721-x6f26ahr 3537 5 usually usually RB cord-028721-x6f26ahr 3537 6 appear appear VBP cord-028721-x6f26ahr 3537 7 4 4 CD cord-028721-x6f26ahr 3537 8 - - SYM cord-028721-x6f26ahr 3537 9 6 6 CD cord-028721-x6f26ahr 3537 10 days day NNS cord-028721-x6f26ahr 3537 11 after after IN cord-028721-x6f26ahr 3537 12 symptoms symptom NNS cord-028721-x6f26ahr 3537 13 of of IN cord-028721-x6f26ahr 3537 14 parotiditis parotiditis NNP cord-028721-x6f26ahr 3537 15 , , , cord-028721-x6f26ahr 3537 16 but but CC cord-028721-x6f26ahr 3537 17 orchitis orchitis NN cord-028721-x6f26ahr 3537 18 may may MD cord-028721-x6f26ahr 3537 19 also also RB cord-028721-x6f26ahr 3537 20 appear appear VB cord-028721-x6f26ahr 3537 21 without without IN cord-028721-x6f26ahr 3537 22 parotid parotid JJ cord-028721-x6f26ahr 3537 23 involvement involvement NN cord-028721-x6f26ahr 3537 24 . . . cord-028721-x6f26ahr 3538 1 1500 1500 CD cord-028721-x6f26ahr 3538 2 Testicular Testicular NNP cord-028721-x6f26ahr 3538 3 involvement involvement NN cord-028721-x6f26ahr 3538 4 is be VBZ cord-028721-x6f26ahr 3538 5 multifocal multifocal JJ cord-028721-x6f26ahr 3538 6 , , , cord-028721-x6f26ahr 3538 7 and and CC cord-028721-x6f26ahr 3538 8 consists consist VBZ cord-028721-x6f26ahr 3538 9 of of IN cord-028721-x6f26ahr 3538 10 acute acute JJ cord-028721-x6f26ahr 3538 11 infl infl NN cord-028721-x6f26ahr 3538 12 ammation ammation NN cord-028721-x6f26ahr 3538 13 of of IN cord-028721-x6f26ahr 3538 14 the the DT cord-028721-x6f26ahr 3538 15 interstitium interstitium JJ cord-028721-x6f26ahr 3538 16 and and CC cord-028721-x6f26ahr 3538 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 3538 18 tubules tubule NNS cord-028721-x6f26ahr 3538 19 . . . cord-028721-x6f26ahr 3539 1 The the DT cord-028721-x6f26ahr 3539 2 tubular tubular JJ cord-028721-x6f26ahr 3539 3 lining lining NN cord-028721-x6f26ahr 3539 4 is be VBZ cord-028721-x6f26ahr 3539 5 destroyed destroy VBN cord-028721-x6f26ahr 3539 6 , , , cord-028721-x6f26ahr 3539 7 and and CC cord-028721-x6f26ahr 3539 8 eventually eventually RB cord-028721-x6f26ahr 3539 9 only only RB cord-028721-x6f26ahr 3539 10 hyalinized hyalinize VBN cord-028721-x6f26ahr 3539 11 tubules tubule NNS cord-028721-x6f26ahr 3539 12 and and CC cord-028721-x6f26ahr 3539 13 clusters cluster NNS cord-028721-x6f26ahr 3539 14 of of IN cord-028721-x6f26ahr 3539 15 Leydig Leydig NNP cord-028721-x6f26ahr 3539 16 cells cell NNS cord-028721-x6f26ahr 3539 17 remain remain VBP cord-028721-x6f26ahr 3539 18 . . . cord-028721-x6f26ahr 3540 1 1501 1501 CD cord-028721-x6f26ahr 3541 1 With with IN cord-028721-x6f26ahr 3541 2 time time NN cord-028721-x6f26ahr 3541 3 , , , cord-028721-x6f26ahr 3541 4 the the DT cord-028721-x6f26ahr 3541 5 testes testis NNS cord-028721-x6f26ahr 3541 6 shrink shrink VBP cord-028721-x6f26ahr 3541 7 and and CC cord-028721-x6f26ahr 3541 8 become become VBP cord-028721-x6f26ahr 3541 9 soft soft JJ cord-028721-x6f26ahr 3541 10 . . . cord-028721-x6f26ahr 3542 1 If if IN cord-028721-x6f26ahr 3542 2 the the DT cord-028721-x6f26ahr 3542 3 infection infection NN cord-028721-x6f26ahr 3542 4 is be VBZ cord-028721-x6f26ahr 3542 5 bilateral bilateral JJ cord-028721-x6f26ahr 3542 6 the the DT cord-028721-x6f26ahr 3542 7 patient patient NN cord-028721-x6f26ahr 3542 8 is be VBZ cord-028721-x6f26ahr 3542 9 usually usually RB cord-028721-x6f26ahr 3542 10 infertile infertile JJ cord-028721-x6f26ahr 3542 11 , , , cord-028721-x6f26ahr 3542 12 with with IN cord-028721-x6f26ahr 3542 13 severe severe JJ cord-028721-x6f26ahr 3542 14 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 3542 15 or or CC cord-028721-x6f26ahr 3542 16 azoospermia azoospermia NN cord-028721-x6f26ahr 3542 17 , , , cord-028721-x6f26ahr 3542 18 although although IN cord-028721-x6f26ahr 3542 19 biopsy biopsy NN cord-028721-x6f26ahr 3542 20 may may MD cord-028721-x6f26ahr 3542 21 reveal reveal VB cord-028721-x6f26ahr 3542 22 the the DT cord-028721-x6f26ahr 3542 23 presence presence NN cord-028721-x6f26ahr 3542 24 of of IN cord-028721-x6f26ahr 3542 25 mature mature JJ cord-028721-x6f26ahr 3542 26 spermatids spermatid NNS cord-028721-x6f26ahr 3542 27 in in IN cord-028721-x6f26ahr 3542 28 some some DT cord-028721-x6f26ahr 3542 29 tubules tubule NNS cord-028721-x6f26ahr 3542 30 , , , cord-028721-x6f26ahr 3542 31 allowing allow VBG cord-028721-x6f26ahr 3542 32 sperm sperm NN cord-028721-x6f26ahr 3542 33 extraction extraction NN cord-028721-x6f26ahr 3542 34 for for IN cord-028721-x6f26ahr 3542 35 paternity paternity NN cord-028721-x6f26ahr 3542 36 . . . cord-028721-x6f26ahr 3543 1 1502 1502 CD cord-028721-x6f26ahr 3544 1 If if IN cord-028721-x6f26ahr 3544 2 only only RB cord-028721-x6f26ahr 3544 3 one one CD cord-028721-x6f26ahr 3544 4 testis testis NN cord-028721-x6f26ahr 3544 5 was be VBD cord-028721-x6f26ahr 3544 6 affected affect VBN cord-028721-x6f26ahr 3544 7 , , , cord-028721-x6f26ahr 3544 8 the the DT cord-028721-x6f26ahr 3544 9 sperm sperm NN cord-028721-x6f26ahr 3544 10 concentration concentration NN cord-028721-x6f26ahr 3544 11 may may MD cord-028721-x6f26ahr 3544 12 be be VB cord-028721-x6f26ahr 3544 13 normal normal JJ cord-028721-x6f26ahr 3544 14 or or CC cord-028721-x6f26ahr 3544 15 slightly slightly RB cord-028721-x6f26ahr 3544 16 decreased decreased JJ cord-028721-x6f26ahr 3544 17 and and CC cord-028721-x6f26ahr 3544 18 fertility fertility NN cord-028721-x6f26ahr 3544 19 is be VBZ cord-028721-x6f26ahr 3544 20 maintained maintain VBN cord-028721-x6f26ahr 3544 21 . . . cord-028721-x6f26ahr 3545 1 Occasionally occasionally RB cord-028721-x6f26ahr 3545 2 the the DT cord-028721-x6f26ahr 3545 3 testicular testicular JJ cord-028721-x6f26ahr 3545 4 damage damage NN cord-028721-x6f26ahr 3545 5 is be VBZ cord-028721-x6f26ahr 3545 6 so so RB cord-028721-x6f26ahr 3545 7 severe severe JJ cord-028721-x6f26ahr 3545 8 that that IN cord-028721-x6f26ahr 3545 9 testicular testicular JJ cord-028721-x6f26ahr 3545 10 endocrine endocrine JJ cord-028721-x6f26ahr 3545 11 function function NN cord-028721-x6f26ahr 3545 12 is be VBZ cord-028721-x6f26ahr 3545 13 impaired impair VBN cord-028721-x6f26ahr 3545 14 , , , cord-028721-x6f26ahr 3545 15 causing cause VBG cord-028721-x6f26ahr 3545 16 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 3545 17 hypogonadism hypogonadism NN cord-028721-x6f26ahr 3545 18 , , , cord-028721-x6f26ahr 3545 19 with with IN cord-028721-x6f26ahr 3545 20 low low JJ cord-028721-x6f26ahr 3545 21 testosterone testosterone NN cord-028721-x6f26ahr 3545 22 levels level NNS cord-028721-x6f26ahr 3545 23 and and CC cord-028721-x6f26ahr 3545 24 regression regression NN cord-028721-x6f26ahr 3545 25 of of IN cord-028721-x6f26ahr 3545 26 secondary secondary JJ cord-028721-x6f26ahr 3545 27 sex sex NN cord-028721-x6f26ahr 3545 28 characteristics characteristic NNS cord-028721-x6f26ahr 3545 29 . . . cord-028721-x6f26ahr 3546 1 Mumps Mumps NNP cord-028721-x6f26ahr 3546 2 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3546 3 is be VBZ cord-028721-x6f26ahr 3546 4 infrequent infrequent JJ cord-028721-x6f26ahr 3546 5 in in IN cord-028721-x6f26ahr 3546 6 childhood childhood NN cord-028721-x6f26ahr 3546 7 . . . cord-028721-x6f26ahr 3547 1 Most Most JJS cord-028721-x6f26ahr 3547 2 bacterial bacterial JJ cord-028721-x6f26ahr 3547 3 orchitis orchitis NN cord-028721-x6f26ahr 3547 4 is be VBZ cord-028721-x6f26ahr 3547 5 associated associate VBN cord-028721-x6f26ahr 3547 6 with with IN cord-028721-x6f26ahr 3547 7 bacterial bacterial JJ cord-028721-x6f26ahr 3547 8 epididymitis epididymitis NN cord-028721-x6f26ahr 3547 9 . . . cord-028721-x6f26ahr 3548 1 Orchitis Orchitis NNP cord-028721-x6f26ahr 3548 2 secondary secondary JJ cord-028721-x6f26ahr 3548 3 to to IN cord-028721-x6f26ahr 3548 4 suppurative suppurative JJ cord-028721-x6f26ahr 3548 5 epididymitis epididymitis NN cord-028721-x6f26ahr 3548 6 caused cause VBN cord-028721-x6f26ahr 3548 7 by by IN cord-028721-x6f26ahr 3548 8 Escherichia Escherichia NNP cord-028721-x6f26ahr 3548 9 coli coli NNS cord-028721-x6f26ahr 3548 10 is be VBZ cord-028721-x6f26ahr 3548 11 most most RBS cord-028721-x6f26ahr 3548 12 common common JJ cord-028721-x6f26ahr 3548 13 . . . cord-028721-x6f26ahr 3549 1 1503 1503 CD cord-028721-x6f26ahr 3550 1 On on IN cord-028721-x6f26ahr 3550 2 light light JJ cord-028721-x6f26ahr 3550 3 microscopy microscopy NN cord-028721-x6f26ahr 3550 4 , , , cord-028721-x6f26ahr 3550 5 the the DT cord-028721-x6f26ahr 3550 6 tubules tubule NNS cord-028721-x6f26ahr 3550 7 are be VBP cord-028721-x6f26ahr 3550 8 effaced efface VBN cord-028721-x6f26ahr 3550 9 by by IN cord-028721-x6f26ahr 3550 10 intense intense JJ cord-028721-x6f26ahr 3550 11 acute acute JJ cord-028721-x6f26ahr 3550 12 infl infl NN cord-028721-x6f26ahr 3550 13 ammation ammation NN cord-028721-x6f26ahr 3550 14 . . . cord-028721-x6f26ahr 3551 1 Chronic chronic JJ cord-028721-x6f26ahr 3551 2 orchitis orchitis NN cord-028721-x6f26ahr 3551 3 with with IN cord-028721-x6f26ahr 3551 4 microabscesses microabscesse NNS cord-028721-x6f26ahr 3551 5 is be VBZ cord-028721-x6f26ahr 3551 6 caused cause VBN cord-028721-x6f26ahr 3551 7 by by IN cord-028721-x6f26ahr 3551 8 E. E. NNP cord-028721-x6f26ahr 3551 9 coli coli NNS cord-028721-x6f26ahr 3551 10 , , , cord-028721-x6f26ahr 3551 11 streptococci streptococcus NNS cord-028721-x6f26ahr 3551 12 , , , cord-028721-x6f26ahr 3551 13 staphylococci staphylococcus NNS cord-028721-x6f26ahr 3551 14 , , , cord-028721-x6f26ahr 3551 15 pneumococci pneumococcus NNS cord-028721-x6f26ahr 3551 16 , , , cord-028721-x6f26ahr 3551 17 Salmonella Salmonella NNP cord-028721-x6f26ahr 3551 18 enteritidis enteritidis NN cord-028721-x6f26ahr 3551 19 , , , cord-028721-x6f26ahr 3551 20 1504 1504 CD cord-028721-x6f26ahr 3551 21 and and CC cord-028721-x6f26ahr 3551 22 Actinomyces Actinomyces NNP cord-028721-x6f26ahr 3551 23 israeli israeli JJ cord-028721-x6f26ahr 3551 24 . . . cord-028721-x6f26ahr 3552 1 1505 1505 CD cord-028721-x6f26ahr 3552 2 , , , cord-028721-x6f26ahr 3552 3 1506 1506 CD cord-028721-x6f26ahr 3553 1 In in IN cord-028721-x6f26ahr 3553 2 some some DT cord-028721-x6f26ahr 3553 3 cases case NNS cord-028721-x6f26ahr 3553 4 of of IN cord-028721-x6f26ahr 3553 5 chronic chronic JJ cord-028721-x6f26ahr 3553 6 bacterial bacterial JJ cord-028721-x6f26ahr 3553 7 orchitis orchitis NN cord-028721-x6f26ahr 3553 8 , , , cord-028721-x6f26ahr 3553 9 the the DT cord-028721-x6f26ahr 3553 10 testis testis NN cord-028721-x6f26ahr 3553 11 contains contain VBZ cord-028721-x6f26ahr 3553 12 an an DT cord-028721-x6f26ahr 3553 13 infl infl NNP cord-028721-x6f26ahr 3553 14 ammatory ammatory NNP cord-028721-x6f26ahr 3553 15 infi infi NNP cord-028721-x6f26ahr 3553 16 ltrate ltrate NNP cord-028721-x6f26ahr 3553 17 consisting consist VBG cord-028721-x6f26ahr 3553 18 of of IN cord-028721-x6f26ahr 3553 19 numerous numerous JJ cord-028721-x6f26ahr 3553 20 histiocytes histiocyte NNS cord-028721-x6f26ahr 3553 21 with with IN cord-028721-x6f26ahr 3553 22 foamy foamy NN cord-028721-x6f26ahr 3553 23 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3553 24 ( ( -LRB- cord-028721-x6f26ahr 3553 25 xanthogranulomatous xanthogranulomatous NNP cord-028721-x6f26ahr 3553 26 orchitis orchitis NNP cord-028721-x6f26ahr 3553 27 ) ) -RRB- cord-028721-x6f26ahr 3554 1 ( ( -LRB- cord-028721-x6f26ahr 3554 2 Fig Fig NNP cord-028721-x6f26ahr 3554 3 . . . cord-028721-x6f26ahr 3555 1 12 12 CD cord-028721-x6f26ahr 3555 2 - - SYM cord-028721-x6f26ahr 3555 3 157 157 CD cord-028721-x6f26ahr 3555 4 ) ) -RRB- cord-028721-x6f26ahr 3555 5 , , , cord-028721-x6f26ahr 3555 6 1507 1507 CD cord-028721-x6f26ahr 3555 7 similar similar JJ cord-028721-x6f26ahr 3555 8 to to IN cord-028721-x6f26ahr 3555 9 that that DT cord-028721-x6f26ahr 3555 10 of of IN cord-028721-x6f26ahr 3555 11 idiopathic idiopathic JJ cord-028721-x6f26ahr 3555 12 granulomatous granulomatous JJ cord-028721-x6f26ahr 3555 13 orchitis orchiti NNS cord-028721-x6f26ahr 3555 14 but but CC cord-028721-x6f26ahr 3555 15 lacking lack VBG cord-028721-x6f26ahr 3555 16 intratubular intratubular JJ cord-028721-x6f26ahr 3555 17 giant giant JJ cord-028721-x6f26ahr 3555 18 cells cell NNS cord-028721-x6f26ahr 3555 19 . . . cord-028721-x6f26ahr 3556 1 Rarely rarely RB cord-028721-x6f26ahr 3556 2 , , , cord-028721-x6f26ahr 3556 3 as as IN cord-028721-x6f26ahr 3556 4 in in IN cord-028721-x6f26ahr 3556 5 Whipple Whipple NNP cord-028721-x6f26ahr 3556 6 's 's POS cord-028721-x6f26ahr 3556 7 disease disease NN cord-028721-x6f26ahr 3556 8 , , , cord-028721-x6f26ahr 3556 9 large large JJ cord-028721-x6f26ahr 3556 10 numbers number NNS cord-028721-x6f26ahr 3556 11 of of IN cord-028721-x6f26ahr 3556 12 bacilli bacillus NNS cord-028721-x6f26ahr 3556 13 are be VBP cord-028721-x6f26ahr 3556 14 present present JJ cord-028721-x6f26ahr 3556 15 in in IN cord-028721-x6f26ahr 3556 16 histiocytes histiocyte NNS cord-028721-x6f26ahr 3556 17 in in IN cord-028721-x6f26ahr 3556 18 the the DT cord-028721-x6f26ahr 3556 19 interstitium interstitium NN cord-028721-x6f26ahr 3556 20 , , , cord-028721-x6f26ahr 3556 21 vascular vascular JJ cord-028721-x6f26ahr 3556 22 walls wall NNS cord-028721-x6f26ahr 3556 23 , , , cord-028721-x6f26ahr 3556 24 and and CC cord-028721-x6f26ahr 3556 25 seminiferous seminiferous JJ cord-028721-x6f26ahr 3556 26 tubules tubule NNS cord-028721-x6f26ahr 3556 27 . . . cord-028721-x6f26ahr 3557 1 The the DT cord-028721-x6f26ahr 3557 2 most most RBS cord-028721-x6f26ahr 3557 3 frequent frequent JJ cord-028721-x6f26ahr 3557 4 complications complication NNS cord-028721-x6f26ahr 3557 5 of of IN cord-028721-x6f26ahr 3557 6 pyogenic pyogenic JJ cord-028721-x6f26ahr 3557 7 bacterial bacterial JJ cord-028721-x6f26ahr 3557 8 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3557 9 are be VBP cord-028721-x6f26ahr 3557 10 scrotal scrotal JJ cord-028721-x6f26ahr 3557 11 pyocele pyocele NN cord-028721-x6f26ahr 3557 12 and and CC cord-028721-x6f26ahr 3557 13 chronic chronic JJ cord-028721-x6f26ahr 3557 14 draining drain VBG cord-028721-x6f26ahr 3557 15 scrotal scrotal JJ cord-028721-x6f26ahr 3557 16 sinus sinus NN cord-028721-x6f26ahr 3557 17 . . . cord-028721-x6f26ahr 3558 1 Small small JJ cord-028721-x6f26ahr 3558 2 fragments fragment NNS cord-028721-x6f26ahr 3558 3 of of IN cord-028721-x6f26ahr 3558 4 testicular testicular JJ cord-028721-x6f26ahr 3558 5 parenchyma parenchyma NNS cord-028721-x6f26ahr 3558 6 may may MD cord-028721-x6f26ahr 3558 7 be be VB cord-028721-x6f26ahr 3558 8 eliminated eliminate VBN cord-028721-x6f26ahr 3558 9 through through IN cord-028721-x6f26ahr 3558 10 the the DT cord-028721-x6f26ahr 3558 11 scrotal scrotal JJ cord-028721-x6f26ahr 3558 12 skin skin NN cord-028721-x6f26ahr 3558 13 , , , cord-028721-x6f26ahr 3558 14 known know VBN cord-028721-x6f26ahr 3558 15 clinically clinically RB cord-028721-x6f26ahr 3558 16 as as IN cord-028721-x6f26ahr 3558 17 fungus fungus NN cord-028721-x6f26ahr 3558 18 testis testis NN cord-028721-x6f26ahr 3558 19 . . . cord-028721-x6f26ahr 3559 1 Another another DT cord-028721-x6f26ahr 3559 2 complication complication NN cord-028721-x6f26ahr 3559 3 is be VBZ cord-028721-x6f26ahr 3559 4 testicular testicular JJ cord-028721-x6f26ahr 3559 5 infarct infarct NN cord-028721-x6f26ahr 3559 6 , , , cord-028721-x6f26ahr 3559 7 resulting result VBG cord-028721-x6f26ahr 3559 8 from from IN cord-028721-x6f26ahr 3559 9 compression compression NN cord-028721-x6f26ahr 3559 10 or or CC cord-028721-x6f26ahr 3559 11 thrombosis thrombosis NN cord-028721-x6f26ahr 3559 12 of of IN cord-028721-x6f26ahr 3559 13 the the DT cord-028721-x6f26ahr 3559 14 veins vein NNS cord-028721-x6f26ahr 3559 15 of of IN cord-028721-x6f26ahr 3559 16 the the DT cord-028721-x6f26ahr 3559 17 spermatic spermatic JJ cord-028721-x6f26ahr 3559 18 cord cord NN cord-028721-x6f26ahr 3559 19 , , , cord-028721-x6f26ahr 3559 20 in in IN cord-028721-x6f26ahr 3559 21 the the DT cord-028721-x6f26ahr 3559 22 scrotal scrotal JJ cord-028721-x6f26ahr 3559 23 neck neck NN cord-028721-x6f26ahr 3559 24 , , , cord-028721-x6f26ahr 3559 25 or or CC cord-028721-x6f26ahr 3559 26 the the DT cord-028721-x6f26ahr 3559 27 superfi superfi NNS cord-028721-x6f26ahr 3559 28 cial cial JJ cord-028721-x6f26ahr 3559 29 inguinal inguinal JJ cord-028721-x6f26ahr 3559 30 ring ring NN cord-028721-x6f26ahr 3559 31 . . . cord-028721-x6f26ahr 3560 1 Most Most JJS cord-028721-x6f26ahr 3560 2 cases case NNS cord-028721-x6f26ahr 3560 3 of of IN cord-028721-x6f26ahr 3560 4 chronic chronic JJ cord-028721-x6f26ahr 3560 5 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3560 6 are be VBP cord-028721-x6f26ahr 3560 7 associated associate VBN cord-028721-x6f26ahr 3560 8 with with IN cord-028721-x6f26ahr 3560 9 granulomas granuloma NNS cord-028721-x6f26ahr 3560 10 in in IN cord-028721-x6f26ahr 3560 11 the the DT cord-028721-x6f26ahr 3560 12 testis testis NN cord-028721-x6f26ahr 3560 13 . . . cord-028721-x6f26ahr 3561 1 Specifi specifi NN cord-028721-x6f26ahr 3561 2 c c NN cord-028721-x6f26ahr 3561 3 causes cause NNS cord-028721-x6f26ahr 3561 4 may may MD cord-028721-x6f26ahr 3561 5 require require VB cord-028721-x6f26ahr 3561 6 special special JJ cord-028721-x6f26ahr 3561 7 stains stain NNS cord-028721-x6f26ahr 3561 8 , , , cord-028721-x6f26ahr 3561 9 cultures culture NNS cord-028721-x6f26ahr 3561 10 , , , cord-028721-x6f26ahr 3561 11 or or CC cord-028721-x6f26ahr 3561 12 serologic serologic JJ cord-028721-x6f26ahr 3561 13 tests test NNS cord-028721-x6f26ahr 3561 14 , , , cord-028721-x6f26ahr 3561 15 and and CC cord-028721-x6f26ahr 3561 16 include include VBP cord-028721-x6f26ahr 3561 17 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3561 18 , , , cord-028721-x6f26ahr 3561 19 syphilis syphili NNS cord-028721-x6f26ahr 3561 20 , , , cord-028721-x6f26ahr 3561 21 leprosy leprosy NN cord-028721-x6f26ahr 3561 22 , , , cord-028721-x6f26ahr 3561 23 brucellosis brucellosis NN cord-028721-x6f26ahr 3561 24 , , , cord-028721-x6f26ahr 3561 25 mycoses mycose NNS cord-028721-x6f26ahr 3561 26 , , , cord-028721-x6f26ahr 3561 27 and and CC cord-028721-x6f26ahr 3561 28 parasitic parasitic JJ cord-028721-x6f26ahr 3561 29 diseases disease NNS cord-028721-x6f26ahr 3561 30 . . . cord-028721-x6f26ahr 3562 1 In in IN cord-028721-x6f26ahr 3562 2 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3562 3 and and CC cord-028721-x6f26ahr 3562 4 idiopathic idiopathic JJ cord-028721-x6f26ahr 3562 5 granulomatous granulomatous JJ cord-028721-x6f26ahr 3562 6 orchitis orchitis NN cord-028721-x6f26ahr 3562 7 , , , cord-028721-x6f26ahr 3562 8 the the DT cord-028721-x6f26ahr 3562 9 agent agent NN cord-028721-x6f26ahr 3562 10 is be VBZ cord-028721-x6f26ahr 3562 11 unknown unknown JJ cord-028721-x6f26ahr 3562 12 . . . cord-028721-x6f26ahr 3563 1 The the DT cord-028721-x6f26ahr 3563 2 incidence incidence NN cord-028721-x6f26ahr 3563 3 of of IN cord-028721-x6f26ahr 3563 4 tuberculous tuberculous JJ cord-028721-x6f26ahr 3563 5 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3563 6 declined decline VBD cord-028721-x6f26ahr 3563 7 after after IN cord-028721-x6f26ahr 3563 8 the the DT cord-028721-x6f26ahr 3563 9 development development NN cord-028721-x6f26ahr 3563 10 of of IN cord-028721-x6f26ahr 3563 11 effective effective JJ cord-028721-x6f26ahr 3563 12 antibiotics antibiotic NNS cord-028721-x6f26ahr 3563 13 , , , cord-028721-x6f26ahr 3563 14 but but CC cord-028721-x6f26ahr 3563 15 it -PRON- PRP cord-028721-x6f26ahr 3563 16 has have VBZ cord-028721-x6f26ahr 3563 17 recently recently RB cord-028721-x6f26ahr 3563 18 undergone undergo VBN cord-028721-x6f26ahr 3563 19 a a DT cord-028721-x6f26ahr 3563 20 resurgence resurgence NN cord-028721-x6f26ahr 3563 21 among among IN cord-028721-x6f26ahr 3563 22 people people NNS cord-028721-x6f26ahr 3563 23 who who WP cord-028721-x6f26ahr 3563 24 have have VBP cord-028721-x6f26ahr 3563 25 emigrated emigrate VBN cord-028721-x6f26ahr 3563 26 from from IN cord-028721-x6f26ahr 3563 27 countries country NNS cord-028721-x6f26ahr 3563 28 with with IN cord-028721-x6f26ahr 3563 29 a a DT cord-028721-x6f26ahr 3563 30 high high JJ cord-028721-x6f26ahr 3563 31 incidence incidence NN cord-028721-x6f26ahr 3563 32 of of IN cord-028721-x6f26ahr 3563 33 the the DT cord-028721-x6f26ahr 3563 34 disease disease NN cord-028721-x6f26ahr 3563 35 and and CC cord-028721-x6f26ahr 3563 36 the the DT cord-028721-x6f26ahr 3563 37 increasing increase VBG cord-028721-x6f26ahr 3563 38 population population NN cord-028721-x6f26ahr 3563 39 of of IN cord-028721-x6f26ahr 3563 40 immunologically immunologically RB cord-028721-x6f26ahr 3563 41 compromised compromise VBN cord-028721-x6f26ahr 3563 42 patients patient NNS cord-028721-x6f26ahr 3563 43 . . . cord-028721-x6f26ahr 3564 1 Most Most JJS cord-028721-x6f26ahr 3564 2 cases case NNS cord-028721-x6f26ahr 3564 3 of of IN cord-028721-x6f26ahr 3564 4 tuberculous tuberculous JJ cord-028721-x6f26ahr 3564 5 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3564 6 are be VBP cord-028721-x6f26ahr 3564 7 associated associate VBN cord-028721-x6f26ahr 3564 8 with with IN cord-028721-x6f26ahr 3564 9 involvement involvement NN cord-028721-x6f26ahr 3564 10 elsewhere elsewhere RB cord-028721-x6f26ahr 3564 11 in in IN cord-028721-x6f26ahr 3564 12 the the DT cord-028721-x6f26ahr 3564 13 genitourinary genitourinary JJ cord-028721-x6f26ahr 3564 14 system system NN cord-028721-x6f26ahr 3564 15 . . . cord-028721-x6f26ahr 3565 1 1508 1508 CD cord-028721-x6f26ahr 3566 1 Tuberculous tuberculous JJ cord-028721-x6f26ahr 3566 2 epididymitis epididymitis NN cord-028721-x6f26ahr 3566 3 is be VBZ cord-028721-x6f26ahr 3566 4 usually usually RB cord-028721-x6f26ahr 3566 5 the the DT cord-028721-x6f26ahr 3566 6 result result NN cord-028721-x6f26ahr 3566 7 of of IN cord-028721-x6f26ahr 3566 8 ascent ascent NN cord-028721-x6f26ahr 3566 9 from from IN cord-028721-x6f26ahr 3566 10 tuberculous tuberculous JJ cord-028721-x6f26ahr 3566 11 prostatitis prostatitis NN cord-028721-x6f26ahr 3566 12 , , , cord-028721-x6f26ahr 3566 13 which which WDT cord-028721-x6f26ahr 3566 14 in in IN cord-028721-x6f26ahr 3566 15 turn turn NN cord-028721-x6f26ahr 3566 16 is be VBZ cord-028721-x6f26ahr 3566 17 often often RB cord-028721-x6f26ahr 3566 18 secondary secondary JJ cord-028721-x6f26ahr 3566 19 to to IN cord-028721-x6f26ahr 3566 20 renal renal JJ cord-028721-x6f26ahr 3566 21 or or CC cord-028721-x6f26ahr 3566 22 pulmonary pulmonary JJ cord-028721-x6f26ahr 3566 23 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3566 24 . . . cord-028721-x6f26ahr 3567 1 The the DT cord-028721-x6f26ahr 3567 2 pattern pattern NN cord-028721-x6f26ahr 3567 3 of of IN cord-028721-x6f26ahr 3567 4 spread spread NN cord-028721-x6f26ahr 3567 5 is be VBZ cord-028721-x6f26ahr 3567 6 different different JJ cord-028721-x6f26ahr 3567 7 in in IN cord-028721-x6f26ahr 3567 8 children child NNS cord-028721-x6f26ahr 3567 9 : : : cord-028721-x6f26ahr 3567 10 more more JJR cord-028721-x6f26ahr 3567 11 than than IN cord-028721-x6f26ahr 3567 12 half half DT cord-028721-x6f26ahr 3567 13 have have VBP cord-028721-x6f26ahr 3567 14 advanced advance VBN cord-028721-x6f26ahr 3567 15 pulmonary pulmonary JJ cord-028721-x6f26ahr 3567 16 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3567 17 , , , cord-028721-x6f26ahr 3567 18 and and CC cord-028721-x6f26ahr 3567 19 the the DT cord-028721-x6f26ahr 3567 20 testis testis NN cord-028721-x6f26ahr 3567 21 is be VBZ cord-028721-x6f26ahr 3567 22 infected infect VBN cord-028721-x6f26ahr 3567 23 through through IN cord-028721-x6f26ahr 3567 24 the the DT cord-028721-x6f26ahr 3567 25 blood blood NN cord-028721-x6f26ahr 3567 26 . . . cord-028721-x6f26ahr 3568 1 1509 1509 CD cord-028721-x6f26ahr 3568 2 More More JJR cord-028721-x6f26ahr 3568 3 than than IN cord-028721-x6f26ahr 3568 4 50 50 CD cord-028721-x6f26ahr 3568 5 % % NN cord-028721-x6f26ahr 3568 6 of of IN cord-028721-x6f26ahr 3568 7 patients patient NNS cord-028721-x6f26ahr 3568 8 with with IN cord-028721-x6f26ahr 3568 9 renal renal JJ cord-028721-x6f26ahr 3568 10 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3568 11 develop develop VB cord-028721-x6f26ahr 3568 12 tuberculous tuberculous JJ cord-028721-x6f26ahr 3568 13 epididymitis epididymitis NN cord-028721-x6f26ahr 3568 14 , , , cord-028721-x6f26ahr 3568 15 and and CC cord-028721-x6f26ahr 3568 16 orchitis orchitis NN cord-028721-x6f26ahr 3568 17 occurs occur VBZ cord-028721-x6f26ahr 3568 18 in in IN cord-028721-x6f26ahr 3568 19 approximately approximately RB cord-028721-x6f26ahr 3568 20 3 3 CD cord-028721-x6f26ahr 3568 21 % % NN cord-028721-x6f26ahr 3568 22 of of IN cord-028721-x6f26ahr 3568 23 patients patient NNS cord-028721-x6f26ahr 3568 24 with with IN cord-028721-x6f26ahr 3568 25 genital genital JJ cord-028721-x6f26ahr 3568 26 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3568 27 , , , cord-028721-x6f26ahr 3568 28 usually usually RB cord-028721-x6f26ahr 3568 29 secondary secondary JJ cord-028721-x6f26ahr 3568 30 to to IN cord-028721-x6f26ahr 3568 31 epididymal epididymal JJ cord-028721-x6f26ahr 3568 32 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3568 33 . . . cord-028721-x6f26ahr 3569 1 It -PRON- PRP cord-028721-x6f26ahr 3569 2 has have VBZ cord-028721-x6f26ahr 3569 3 been be VBN cord-028721-x6f26ahr 3569 4 suggested suggest VBN cord-028721-x6f26ahr 3569 5 that that IN cord-028721-x6f26ahr 3569 6 some some DT cord-028721-x6f26ahr 3569 7 cases case NNS cord-028721-x6f26ahr 3569 8 of of IN cord-028721-x6f26ahr 3569 9 tuberculous tuberculous JJ cord-028721-x6f26ahr 3569 10 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3569 11 are be VBP cord-028721-x6f26ahr 3569 12 sexually sexually RB cord-028721-x6f26ahr 3569 13 transmitted transmit VBN cord-028721-x6f26ahr 3569 14 . . . cord-028721-x6f26ahr 3570 1 1510 1510 CD cord-028721-x6f26ahr 3570 2 Tuberculous tuberculous JJ cord-028721-x6f26ahr 3570 3 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3570 4 occurs occur VBZ cord-028721-x6f26ahr 3570 5 mainly mainly RB cord-028721-x6f26ahr 3570 6 in in IN cord-028721-x6f26ahr 3570 7 adults adult NNS cord-028721-x6f26ahr 3570 8 : : : cord-028721-x6f26ahr 3570 9 72 72 CD cord-028721-x6f26ahr 3570 10 % % NN cord-028721-x6f26ahr 3570 11 of of IN cord-028721-x6f26ahr 3570 12 patients patient NNS cord-028721-x6f26ahr 3570 13 are be VBP cord-028721-x6f26ahr 3570 14 older old JJR cord-028721-x6f26ahr 3570 15 than than IN cord-028721-x6f26ahr 3570 16 35 35 CD cord-028721-x6f26ahr 3570 17 years year NNS cord-028721-x6f26ahr 3570 18 , , , cord-028721-x6f26ahr 3570 19 and and CC cord-028721-x6f26ahr 3570 20 18 18 CD cord-028721-x6f26ahr 3570 21 % % NN cord-028721-x6f26ahr 3570 22 are be VBP cord-028721-x6f26ahr 3570 23 over over IN cord-028721-x6f26ahr 3570 24 65 65 CD cord-028721-x6f26ahr 3570 25 years year NNS cord-028721-x6f26ahr 3570 26 . . . cord-028721-x6f26ahr 3571 1 The the DT cord-028721-x6f26ahr 3571 2 signs sign NNS cord-028721-x6f26ahr 3571 3 and and CC cord-028721-x6f26ahr 3571 4 symptoms symptom NNS cord-028721-x6f26ahr 3571 5 may may MD cord-028721-x6f26ahr 3571 6 be be VB cord-028721-x6f26ahr 3571 7 mild mild JJ cord-028721-x6f26ahr 3571 8 , , , cord-028721-x6f26ahr 3571 9 consisting consist VBG cord-028721-x6f26ahr 3571 10 only only RB cord-028721-x6f26ahr 3571 11 of of IN cord-028721-x6f26ahr 3571 12 testicular testicular JJ cord-028721-x6f26ahr 3571 13 enlargement enlargement NN cord-028721-x6f26ahr 3571 14 and and CC cord-028721-x6f26ahr 3571 15 scrotal scrotal JJ cord-028721-x6f26ahr 3571 16 pain pain NN cord-028721-x6f26ahr 3571 17 . . . cord-028721-x6f26ahr 3572 1 In in IN cord-028721-x6f26ahr 3572 2 such such JJ cord-028721-x6f26ahr 3572 3 cases case NNS cord-028721-x6f26ahr 3572 4 , , , cord-028721-x6f26ahr 3572 5 fever fever NN cord-028721-x6f26ahr 3572 6 is be VBZ cord-028721-x6f26ahr 3572 7 infrequent infrequent JJ cord-028721-x6f26ahr 3572 8 and and CC cord-028721-x6f26ahr 3572 9 constitutional constitutional JJ cord-028721-x6f26ahr 3572 10 symptoms symptom NNS cord-028721-x6f26ahr 3572 11 may may MD cord-028721-x6f26ahr 3572 12 be be VB cord-028721-x6f26ahr 3572 13 absent absent JJ cord-028721-x6f26ahr 3572 14 . . . cord-028721-x6f26ahr 3573 1 1511 1511 CD cord-028721-x6f26ahr 3574 1 Histologically histologically RB cord-028721-x6f26ahr 3574 2 , , , cord-028721-x6f26ahr 3574 3 there there EX cord-028721-x6f26ahr 3574 4 are be VBP cord-028721-x6f26ahr 3574 5 typical typical JJ cord-028721-x6f26ahr 3574 6 caseating caseating NN cord-028721-x6f26ahr 3574 7 and and CC cord-028721-x6f26ahr 3574 8 noncaseating noncaseating NN cord-028721-x6f26ahr 3574 9 granulomas granuloma NNS cord-028721-x6f26ahr 3574 10 that that WDT cord-028721-x6f26ahr 3574 11 destroy destroy VBP cord-028721-x6f26ahr 3574 12 the the DT cord-028721-x6f26ahr 3574 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 3574 14 tubules tubule NNS cord-028721-x6f26ahr 3574 15 _SP cord-028721-x6f26ahr 3574 16 and and CC cord-028721-x6f26ahr 3574 17 interstitium interstitium NNP cord-028721-x6f26ahr 3575 1 ( ( -LRB- cord-028721-x6f26ahr 3575 2 Figs Figs NNP cord-028721-x6f26ahr 3575 3 12 12 CD cord-028721-x6f26ahr 3575 4 - - SYM cord-028721-x6f26ahr 3575 5 158 158 CD cord-028721-x6f26ahr 3575 6 , , , cord-028721-x6f26ahr 3575 7 12 12 CD cord-028721-x6f26ahr 3575 8 - - SYM cord-028721-x6f26ahr 3575 9 159 159 CD cord-028721-x6f26ahr 3575 10 ) ) -RRB- cord-028721-x6f26ahr 3575 11 . . . cord-028721-x6f26ahr 3576 1 In in IN cord-028721-x6f26ahr 3576 2 immunosuppressed immunosuppressed JJ cord-028721-x6f26ahr 3576 3 patients patient NNS cord-028721-x6f26ahr 3576 4 , , , cord-028721-x6f26ahr 3576 5 the the DT cord-028721-x6f26ahr 3576 6 granulomas granuloma NNS cord-028721-x6f26ahr 3576 7 consist consist VBP cord-028721-x6f26ahr 3576 8 of of IN cord-028721-x6f26ahr 3576 9 epithelioid epithelioid NNP cord-028721-x6f26ahr 3576 10 histiocytes histiocytes NNPS cord-028721-x6f26ahr 3576 11 and and CC cord-028721-x6f26ahr 3576 12 a a DT cord-028721-x6f26ahr 3576 13 few few JJ cord-028721-x6f26ahr 3576 14 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3576 15 with with IN cord-028721-x6f26ahr 3576 16 rare rare JJ cord-028721-x6f26ahr 3576 17 giant giant JJ cord-028721-x6f26ahr 3576 18 cells cell NNS cord-028721-x6f26ahr 3576 19 . . . cord-028721-x6f26ahr 3577 1 Acid acid NN cord-028721-x6f26ahr 3577 2 - - HYPH cord-028721-x6f26ahr 3577 3 fast fast JJ cord-028721-x6f26ahr 3577 4 bacilli bacilli JJ cord-028721-x6f26ahr 3577 5 tend tend VBP cord-028721-x6f26ahr 3577 6 to to TO cord-028721-x6f26ahr 3577 7 be be VB cord-028721-x6f26ahr 3577 8 more more RBR cord-028721-x6f26ahr 3577 9 numerous numerous JJ cord-028721-x6f26ahr 3577 10 in in IN cord-028721-x6f26ahr 3577 11 immunosuppressed immunosuppressed JJ cord-028721-x6f26ahr 3577 12 patients patient NNS cord-028721-x6f26ahr 3577 13 . . . cord-028721-x6f26ahr 3578 1 Similar similar JJ cord-028721-x6f26ahr 3578 2 lesions lesion NNS cord-028721-x6f26ahr 3578 3 may may MD cord-028721-x6f26ahr 3578 4 be be VB cord-028721-x6f26ahr 3578 5 observed observe VBN cord-028721-x6f26ahr 3578 6 in in IN cord-028721-x6f26ahr 3578 7 orchidoepididymitis orchidoepididymitis NN cord-028721-x6f26ahr 3578 8 caused cause VBN cord-028721-x6f26ahr 3578 9 by by IN cord-028721-x6f26ahr 3578 10 bacillus bacillus NN cord-028721-x6f26ahr 3578 11 Calmette Calmette NNP cord-028721-x6f26ahr 3578 12 - - HYPH cord-028721-x6f26ahr 3578 13 Guérin Guérin NNP cord-028721-x6f26ahr 3578 14 , , , cord-028721-x6f26ahr 3578 15 which which WDT cord-028721-x6f26ahr 3578 16 is be VBZ cord-028721-x6f26ahr 3578 17 usually usually RB cord-028721-x6f26ahr 3578 18 used use VBN cord-028721-x6f26ahr 3578 19 for for IN cord-028721-x6f26ahr 3578 20 intravesical intravesical JJ cord-028721-x6f26ahr 3578 21 instillation instillation NN cord-028721-x6f26ahr 3578 22 in in IN cord-028721-x6f26ahr 3578 23 patients patient NNS cord-028721-x6f26ahr 3578 24 with with IN cord-028721-x6f26ahr 3578 25 vesicular vesicular JJ cord-028721-x6f26ahr 3578 26 urothelial urothelial JJ cord-028721-x6f26ahr 3578 27 carcinoma carcinoma NN cord-028721-x6f26ahr 3578 28 . . . cord-028721-x6f26ahr 3579 1 1512 1512 CD cord-028721-x6f26ahr 3580 1 Syphilis syphili NNS cord-028721-x6f26ahr 3580 2 Syphilitic syphilitic JJ cord-028721-x6f26ahr 3580 3 orchitis orchiti NNS cord-028721-x6f26ahr 3580 4 may may MD cord-028721-x6f26ahr 3580 5 be be VB cord-028721-x6f26ahr 3580 6 congenital congenital JJ cord-028721-x6f26ahr 3580 7 or or CC cord-028721-x6f26ahr 3580 8 acquired acquire VBN cord-028721-x6f26ahr 3580 9 . . . cord-028721-x6f26ahr 3581 1 In in IN cord-028721-x6f26ahr 3581 2 congenital congenital JJ cord-028721-x6f26ahr 3581 3 orchitis orchitis NN cord-028721-x6f26ahr 3581 4 , , , cord-028721-x6f26ahr 3581 5 both both DT cord-028721-x6f26ahr 3581 6 testes testis NNS cord-028721-x6f26ahr 3581 7 are be VBP cord-028721-x6f26ahr 3581 8 enlarged enlarge VBN cord-028721-x6f26ahr 3581 9 at at IN cord-028721-x6f26ahr 3581 10 birth birth NN cord-028721-x6f26ahr 3581 11 . . . cord-028721-x6f26ahr 3582 1 The the DT cord-028721-x6f26ahr 3582 2 histological histological JJ cord-028721-x6f26ahr 3582 3 fi fi NN cord-028721-x6f26ahr 3582 4 ndings nding NNS cord-028721-x6f26ahr 3582 5 are be VBP cord-028721-x6f26ahr 3582 6 similar similar JJ cord-028721-x6f26ahr 3582 7 to to IN cord-028721-x6f26ahr 3582 8 those those DT cord-028721-x6f26ahr 3582 9 of of IN cord-028721-x6f26ahr 3582 10 the the DT cord-028721-x6f26ahr 3582 11 interstitial interstitial JJ cord-028721-x6f26ahr 3582 12 orchitis orchitis NN cord-028721-x6f26ahr 3582 13 of of IN cord-028721-x6f26ahr 3582 14 acquired acquire VBN cord-028721-x6f26ahr 3582 15 syphilis syphili NNS cord-028721-x6f26ahr 3582 16 . . . cord-028721-x6f26ahr 3583 1 If if IN cord-028721-x6f26ahr 3583 2 diagnosis diagnosis NN cord-028721-x6f26ahr 3583 3 is be VBZ cord-028721-x6f26ahr 3583 4 delayed delay VBN cord-028721-x6f26ahr 3583 5 until until IN cord-028721-x6f26ahr 3583 6 puberty puberty NN cord-028721-x6f26ahr 3583 7 , , , cord-028721-x6f26ahr 3583 8 the the DT cord-028721-x6f26ahr 3583 9 testis testis NN cord-028721-x6f26ahr 3583 10 often often RB cord-028721-x6f26ahr 3583 11 shows show VBZ cord-028721-x6f26ahr 3583 12 retraction retraction NN cord-028721-x6f26ahr 3583 13 and and CC cord-028721-x6f26ahr 3583 14 fi fi NN cord-028721-x6f26ahr 3583 15 brosis brosis NN cord-028721-x6f26ahr 3583 16 . . . cord-028721-x6f26ahr 3584 1 In in IN cord-028721-x6f26ahr 3584 2 adults adult NNS cord-028721-x6f26ahr 3584 3 , , , cord-028721-x6f26ahr 3584 4 acquired acquire VBN cord-028721-x6f26ahr 3584 5 orchitis orchitis NN cord-028721-x6f26ahr 3584 6 is be VBZ cord-028721-x6f26ahr 3584 7 a a DT cord-028721-x6f26ahr 3584 8 complication complication NN cord-028721-x6f26ahr 3584 9 of of IN cord-028721-x6f26ahr 3584 10 the the DT cord-028721-x6f26ahr 3584 11 tertiary tertiary JJ cord-028721-x6f26ahr 3584 12 stage stage NN cord-028721-x6f26ahr 3584 13 of of IN cord-028721-x6f26ahr 3584 14 syphilis syphilis NN cord-028721-x6f26ahr 3584 15 and and CC cord-028721-x6f26ahr 3584 16 has have VBZ cord-028721-x6f26ahr 3584 17 two two CD cord-028721-x6f26ahr 3584 18 characteristic characteristic JJ cord-028721-x6f26ahr 3584 19 histologic histologic JJ cord-028721-x6f26ahr 3584 20 patterns pattern NNS cord-028721-x6f26ahr 3584 21 : : : cord-028721-x6f26ahr 3584 22 interstitial interstitial JJ cord-028721-x6f26ahr 3584 23 infl infl NNP cord-028721-x6f26ahr 3584 24 ammation ammation NNP cord-028721-x6f26ahr 3584 25 and and CC cord-028721-x6f26ahr 3584 26 gumma gumma NNP cord-028721-x6f26ahr 3584 27 . . . cord-028721-x6f26ahr 3585 1 Early early RB cord-028721-x6f26ahr 3585 2 in in IN cord-028721-x6f26ahr 3585 3 the the DT cord-028721-x6f26ahr 3585 4 disease disease NN cord-028721-x6f26ahr 3585 5 , , , cord-028721-x6f26ahr 3585 6 patients patient NNS cord-028721-x6f26ahr 3585 7 with with IN cord-028721-x6f26ahr 3585 8 interstitial interstitial JJ cord-028721-x6f26ahr 3585 9 orchitis orchiti NNS cord-028721-x6f26ahr 3585 10 have have VBP cord-028721-x6f26ahr 3585 11 painless painless JJ cord-028721-x6f26ahr 3585 12 enlargement enlargement NN cord-028721-x6f26ahr 3585 13 . . . cord-028721-x6f26ahr 3586 1 Grossly grossly RB cord-028721-x6f26ahr 3586 2 , , , cord-028721-x6f26ahr 3586 3 the the DT cord-028721-x6f26ahr 3586 4 parenchyma parenchyma NN cord-028721-x6f26ahr 3586 5 is be VBZ cord-028721-x6f26ahr 3586 6 gray gray JJ cord-028721-x6f26ahr 3586 7 with with IN cord-028721-x6f26ahr 3586 8 translucent translucent JJ cord-028721-x6f26ahr 3586 9 areas area NNS cord-028721-x6f26ahr 3586 10 . . . cord-028721-x6f26ahr 3587 1 Histologically histologically RB cord-028721-x6f26ahr 3587 2 , , , cord-028721-x6f26ahr 3587 3 plasma plasma NN cord-028721-x6f26ahr 3587 4 cells cell NNS cord-028721-x6f26ahr 3587 5 are be VBP cord-028721-x6f26ahr 3587 6 abundant abundant JJ cord-028721-x6f26ahr 3587 7 . . . cord-028721-x6f26ahr 3588 1 The the DT cord-028721-x6f26ahr 3588 2 infl infl NN cord-028721-x6f26ahr 3588 3 ammation ammation NN cord-028721-x6f26ahr 3588 4 begins begin VBZ cord-028721-x6f26ahr 3588 5 in in IN cord-028721-x6f26ahr 3588 6 the the DT cord-028721-x6f26ahr 3588 7 mediastinum mediastinum FW cord-028721-x6f26ahr 3588 8 testis testis NN cord-028721-x6f26ahr 3588 9 and and CC cord-028721-x6f26ahr 3588 10 testicular testicular JJ cord-028721-x6f26ahr 3588 11 septa septa NNP cord-028721-x6f26ahr 3588 12 , , , cord-028721-x6f26ahr 3588 13 later later RB cord-028721-x6f26ahr 3588 14 extending extend VBG cord-028721-x6f26ahr 3588 15 through through IN cord-028721-x6f26ahr 3588 16 the the DT cord-028721-x6f26ahr 3588 17 parenchyma parenchyma NN cord-028721-x6f26ahr 3588 18 as as IN cord-028721-x6f26ahr 3588 19 the the DT cord-028721-x6f26ahr 3588 20 seminiferous seminiferous JJ cord-028721-x6f26ahr 3588 21 tubules tubule NNS cord-028721-x6f26ahr 3588 22 lose lose VBP cord-028721-x6f26ahr 3588 23 their -PRON- PRP$ cord-028721-x6f26ahr 3588 24 cellular cellular JJ cord-028721-x6f26ahr 3588 25 lining lining NN cord-028721-x6f26ahr 3588 26 and and CC cord-028721-x6f26ahr 3588 27 undergo undergo VB cord-028721-x6f26ahr 3588 28 sclerosis sclerosis NN cord-028721-x6f26ahr 3588 29 . . . cord-028721-x6f26ahr 3589 1 Initially initially RB cord-028721-x6f26ahr 3589 2 , , , cord-028721-x6f26ahr 3589 3 the the DT cord-028721-x6f26ahr 3589 4 arteries artery NNS cord-028721-x6f26ahr 3589 5 show show VBP cord-028721-x6f26ahr 3589 6 an an DT cord-028721-x6f26ahr 3589 7 obliterans obliterans NN cord-028721-x6f26ahr 3589 8 type type NN cord-028721-x6f26ahr 3589 9 of of IN cord-028721-x6f26ahr 3589 10 endarteritis endarteritis NN cord-028721-x6f26ahr 3589 11 . . . cord-028721-x6f26ahr 3590 1 Small small JJ cord-028721-x6f26ahr 3590 2 gummas gummas NN cord-028721-x6f26ahr 3590 3 may may MD cord-028721-x6f26ahr 3590 4 be be VB cord-028721-x6f26ahr 3590 5 observed observe VBN cord-028721-x6f26ahr 3590 6 . . . cord-028721-x6f26ahr 3591 1 Eventually eventually RB cord-028721-x6f26ahr 3591 2 , , , cord-028721-x6f26ahr 3591 3 the the DT cord-028721-x6f26ahr 3591 4 infl infl NN cord-028721-x6f26ahr 3591 5 ammation ammation NNP cord-028721-x6f26ahr 3591 6 subsides subside VBZ cord-028721-x6f26ahr 3591 7 and and CC cord-028721-x6f26ahr 3591 8 is be VBZ cord-028721-x6f26ahr 3591 9 replaced replace VBN cord-028721-x6f26ahr 3591 10 by by IN cord-028721-x6f26ahr 3591 11 fi fi NNP cord-028721-x6f26ahr 3591 12 brosis brosis NN cord-028721-x6f26ahr 3591 13 . . . cord-028721-x6f26ahr 3592 1 The the DT cord-028721-x6f26ahr 3592 2 epididymis epididymis NN cord-028721-x6f26ahr 3592 3 is be VBZ cord-028721-x6f26ahr 3592 4 usually usually RB cord-028721-x6f26ahr 3592 5 not not RB cord-028721-x6f26ahr 3592 6 affected affect VBN cord-028721-x6f26ahr 3592 7 . . . cord-028721-x6f26ahr 3593 1 Gummatous Gummatous NNP cord-028721-x6f26ahr 3593 2 orchitis orchitis NN cord-028721-x6f26ahr 3593 3 is be VBZ cord-028721-x6f26ahr 3593 4 characterized characterize VBN cord-028721-x6f26ahr 3593 5 by by IN cord-028721-x6f26ahr 3593 6 the the DT cord-028721-x6f26ahr 3593 7 presence presence NN cord-028721-x6f26ahr 3593 8 of of IN cord-028721-x6f26ahr 3593 9 one one CD cord-028721-x6f26ahr 3593 10 or or CC cord-028721-x6f26ahr 3593 11 several several JJ cord-028721-x6f26ahr 3593 12 well well RB cord-028721-x6f26ahr 3593 13 - - HYPH cord-028721-x6f26ahr 3593 14 delineated delineate VBN cord-028721-x6f26ahr 3593 15 grossly grossly RB cord-028721-x6f26ahr 3593 16 gray gray JJ cord-028721-x6f26ahr 3593 17 - - HYPH cord-028721-x6f26ahr 3593 18 yellow yellow JJ cord-028721-x6f26ahr 3593 19 zones zone NNS cord-028721-x6f26ahr 3593 20 of of IN cord-028721-x6f26ahr 3593 21 necrosis necrosis NN cord-028721-x6f26ahr 3593 22 . . . cord-028721-x6f26ahr 3594 1 1513 1513 CD cord-028721-x6f26ahr 3595 1 Histologically histologically RB cord-028721-x6f26ahr 3595 2 , , , cord-028721-x6f26ahr 3595 3 ghostly ghostly JJ cord-028721-x6f26ahr 3595 4 silhouettes silhouette NNS cord-028721-x6f26ahr 3595 5 of of IN cord-028721-x6f26ahr 3595 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 3595 7 tubules tubule NNS cord-028721-x6f26ahr 3595 8 are be VBP cord-028721-x6f26ahr 3595 9 visible visible JJ cord-028721-x6f26ahr 3595 10 within within IN cord-028721-x6f26ahr 3595 11 the the DT cord-028721-x6f26ahr 3595 12 gumma gumma NN cord-028721-x6f26ahr 3595 13 , , , cord-028721-x6f26ahr 3595 14 surrounded surround VBN cord-028721-x6f26ahr 3595 15 by by IN cord-028721-x6f26ahr 3595 16 infl infl NNP cord-028721-x6f26ahr 3595 17 ammation ammation NNP cord-028721-x6f26ahr 3595 18 consisting consist VBG cord-028721-x6f26ahr 3595 19 of of IN cord-028721-x6f26ahr 3595 20 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3595 21 , , , cord-028721-x6f26ahr 3595 22 plasma plasma NN cord-028721-x6f26ahr 3595 23 cells cell NNS cord-028721-x6f26ahr 3595 24 , , , cord-028721-x6f26ahr 3595 25 and and CC cord-028721-x6f26ahr 3595 26 scattered scatter VBN cord-028721-x6f26ahr 3595 27 giant giant JJ cord-028721-x6f26ahr 3595 28 cells cell NNS cord-028721-x6f26ahr 3595 29 . . . cord-028721-x6f26ahr 3596 1 In in IN cord-028721-x6f26ahr 3596 2 most most JJS cord-028721-x6f26ahr 3596 3 cases case NNS cord-028721-x6f26ahr 3596 4 spirochetes spirochete NNS cord-028721-x6f26ahr 3596 5 may may MD cord-028721-x6f26ahr 3596 6 be be VB cord-028721-x6f26ahr 3596 7 demonstrated demonstrate VBN cord-028721-x6f26ahr 3596 8 histochemically histochemically RB cord-028721-x6f26ahr 3596 9 with with IN cord-028721-x6f26ahr 3596 10 Warthin Warthin NNP cord-028721-x6f26ahr 3596 11 - - HYPH cord-028721-x6f26ahr 3596 12 Starry Starry NNP cord-028721-x6f26ahr 3596 13 silver silver NN cord-028721-x6f26ahr 3596 14 stain stain NN cord-028721-x6f26ahr 3596 15 , , , cord-028721-x6f26ahr 3596 16 but but CC cord-028721-x6f26ahr 3596 17 the the DT cord-028721-x6f26ahr 3596 18 most most RBS cord-028721-x6f26ahr 3596 19 specifi specifi JJ cord-028721-x6f26ahr 3596 20 c c NN cord-028721-x6f26ahr 3596 21 diagnostic diagnostic JJ cord-028721-x6f26ahr 3596 22 technique technique NN cord-028721-x6f26ahr 3596 23 is be VBZ cord-028721-x6f26ahr 3596 24 genetic genetic JJ cord-028721-x6f26ahr 3596 25 testing testing NN cord-028721-x6f26ahr 3596 26 . . . cord-028721-x6f26ahr 3597 1 The the DT cord-028721-x6f26ahr 3597 2 testis testis NN cord-028721-x6f26ahr 3597 3 may may MD cord-028721-x6f26ahr 3597 4 be be VB cord-028721-x6f26ahr 3597 5 infected infect VBN cord-028721-x6f26ahr 3597 6 in in IN cord-028721-x6f26ahr 3597 7 patients patient NNS cord-028721-x6f26ahr 3597 8 with with IN cord-028721-x6f26ahr 3597 9 lepromatous lepromatous JJ cord-028721-x6f26ahr 3597 10 or or CC cord-028721-x6f26ahr 3597 11 borderline borderline JJ cord-028721-x6f26ahr 3597 12 leprosy leprosy NN cord-028721-x6f26ahr 3597 13 . . . cord-028721-x6f26ahr 3598 1 Frequent frequent JJ cord-028721-x6f26ahr 3598 2 involvement involvement NN cord-028721-x6f26ahr 3598 3 of of IN cord-028721-x6f26ahr 3598 4 the the DT cord-028721-x6f26ahr 3598 5 testis testis NN cord-028721-x6f26ahr 3598 6 in in IN cord-028721-x6f26ahr 3598 7 lepromatous lepromatous JJ cord-028721-x6f26ahr 3598 8 leprosy leprosy NN cord-028721-x6f26ahr 3598 9 results result NNS cord-028721-x6f26ahr 3598 10 from from IN cord-028721-x6f26ahr 3598 11 the the DT cord-028721-x6f26ahr 3598 12 low low JJ cord-028721-x6f26ahr 3598 13 intrascrotal intrascrotal JJ cord-028721-x6f26ahr 3598 14 temperature temperature NN cord-028721-x6f26ahr 3598 15 that that WDT cord-028721-x6f26ahr 3598 16 promotes promote VBZ cord-028721-x6f26ahr 3598 17 growth growth NN cord-028721-x6f26ahr 3598 18 of of IN cord-028721-x6f26ahr 3598 19 the the DT cord-028721-x6f26ahr 3598 20 bacilli bacilli NN cord-028721-x6f26ahr 3598 21 . . . cord-028721-x6f26ahr 3599 1 Orchitis Orchitis NNP cord-028721-x6f26ahr 3599 2 is be VBZ cord-028721-x6f26ahr 3599 3 usually usually RB cord-028721-x6f26ahr 3599 4 bilateral bilateral JJ cord-028721-x6f26ahr 3599 5 , , , cord-028721-x6f26ahr 3599 6 although although IN cord-028721-x6f26ahr 3599 7 the the DT cord-028721-x6f26ahr 3599 8 degree degree NN cord-028721-x6f26ahr 3599 9 of of IN cord-028721-x6f26ahr 3599 10 involvement involvement NN cord-028721-x6f26ahr 3599 11 may may MD cord-028721-x6f26ahr 3599 12 differ differ VB cord-028721-x6f26ahr 3599 13 between between IN cord-028721-x6f26ahr 3599 14 the the DT cord-028721-x6f26ahr 3599 15 testes testis NNS cord-028721-x6f26ahr 3599 16 . . . cord-028721-x6f26ahr 3600 1 Occasionally occasionally RB cord-028721-x6f26ahr 3600 2 , , , cord-028721-x6f26ahr 3600 3 testicular testicular JJ cord-028721-x6f26ahr 3600 4 involvement involvement NN cord-028721-x6f26ahr 3600 5 may may MD cord-028721-x6f26ahr 3600 6 be be VB cord-028721-x6f26ahr 3600 7 the the DT cord-028721-x6f26ahr 3600 8 sole sole JJ cord-028721-x6f26ahr 3600 9 indication indication NN cord-028721-x6f26ahr 3600 10 of of IN cord-028721-x6f26ahr 3600 11 the the DT cord-028721-x6f26ahr 3600 12 infection infection NN cord-028721-x6f26ahr 3600 13 , , , cord-028721-x6f26ahr 3600 14 and and CC cord-028721-x6f26ahr 3600 15 the the DT cord-028721-x6f26ahr 3600 16 diagnosis diagnosis NN cord-028721-x6f26ahr 3600 17 may may MD cord-028721-x6f26ahr 3600 18 be be VB cord-028721-x6f26ahr 3600 19 made make VBN cord-028721-x6f26ahr 3600 20 by by IN cord-028721-x6f26ahr 3600 21 testicular testicular JJ cord-028721-x6f26ahr 3600 22 biopsy biopsy NN cord-028721-x6f26ahr 3600 23 . . . cord-028721-x6f26ahr 3601 1 1514 1514 CD cord-028721-x6f26ahr 3602 1 The the DT cord-028721-x6f26ahr 3602 2 histologic histologic JJ cord-028721-x6f26ahr 3602 3 fi fi NN cord-028721-x6f26ahr 3602 4 ndings nding NNS cord-028721-x6f26ahr 3602 5 in in IN cord-028721-x6f26ahr 3602 6 the the DT cord-028721-x6f26ahr 3602 7 testis testis NN cord-028721-x6f26ahr 3602 8 vary vary VBP cord-028721-x6f26ahr 3602 9 with with IN cord-028721-x6f26ahr 3602 10 the the DT cord-028721-x6f26ahr 3602 11 duration duration NN cord-028721-x6f26ahr 3602 12 of of IN cord-028721-x6f26ahr 3602 13 the the DT cord-028721-x6f26ahr 3602 14 infection infection NN cord-028721-x6f26ahr 3602 15 . . . cord-028721-x6f26ahr 3603 1 Initially initially RB cord-028721-x6f26ahr 3603 2 , , , cord-028721-x6f26ahr 3603 3 there there EX cord-028721-x6f26ahr 3603 4 is be VBZ cord-028721-x6f26ahr 3603 5 perivascular perivascular JJ cord-028721-x6f26ahr 3603 6 lymphocytic lymphocytic JJ cord-028721-x6f26ahr 3603 7 infl infl NNP cord-028721-x6f26ahr 3603 8 ammation ammation NNP cord-028721-x6f26ahr 3603 9 and and CC cord-028721-x6f26ahr 3603 10 interstitial interstitial JJ cord-028721-x6f26ahr 3603 11 macrophages macrophage NNS cord-028721-x6f26ahr 3603 12 that that WDT cord-028721-x6f26ahr 3603 13 contain contain VBP cord-028721-x6f26ahr 3603 14 numerous numerous JJ cord-028721-x6f26ahr 3603 15 acid acid NN cord-028721-x6f26ahr 3603 16 - - HYPH cord-028721-x6f26ahr 3603 17 fast fast JJ cord-028721-x6f26ahr 3603 18 bacilli bacilli NN cord-028721-x6f26ahr 3603 19 . . . cord-028721-x6f26ahr 3604 1 Later later RBR cord-028721-x6f26ahr 3604 2 , , , cord-028721-x6f26ahr 3604 3 the the DT cord-028721-x6f26ahr 3604 4 seminiferous seminiferous JJ cord-028721-x6f26ahr 3604 5 tubules tubule NNS cord-028721-x6f26ahr 3604 6 undergo undergo VBP cord-028721-x6f26ahr 3604 7 atrophy atrophy NN cord-028721-x6f26ahr 3604 8 , , , cord-028721-x6f26ahr 3604 9 the the DT cord-028721-x6f26ahr 3604 10 Leydig Leydig NNP cord-028721-x6f26ahr 3604 11 cells cell NNS cord-028721-x6f26ahr 3604 12 cluster cluster NN cord-028721-x6f26ahr 3604 13 , , , cord-028721-x6f26ahr 3604 14 and and CC cord-028721-x6f26ahr 3604 15 blood blood NN cord-028721-x6f26ahr 3604 16 vessels vessel NNS cord-028721-x6f26ahr 3604 17 show show VBP cord-028721-x6f26ahr 3604 18 endarteritis endarteritis NN cord-028721-x6f26ahr 3604 19 obliterans obliteran NNS cord-028721-x6f26ahr 3604 20 . . . cord-028721-x6f26ahr 3605 1 Finally finally RB cord-028721-x6f26ahr 3605 2 , , , cord-028721-x6f26ahr 3605 3 the the DT cord-028721-x6f26ahr 3605 4 testis testis NN cord-028721-x6f26ahr 3605 5 is be VBZ cord-028721-x6f26ahr 3605 6 replaced replace VBN cord-028721-x6f26ahr 3605 7 by by IN cord-028721-x6f26ahr 3605 8 fi fi NN cord-028721-x6f26ahr 3605 9 brous brous JJ cord-028721-x6f26ahr 3605 10 tissue tissue NN cord-028721-x6f26ahr 3605 11 with with IN cord-028721-x6f26ahr 3605 12 a a DT cord-028721-x6f26ahr 3605 13 few few JJ cord-028721-x6f26ahr 3605 14 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3605 15 and and CC cord-028721-x6f26ahr 3605 16 macrophages macrophage NNS cord-028721-x6f26ahr 3605 17 containing contain VBG cord-028721-x6f26ahr 3605 18 acid acid NN cord-028721-x6f26ahr 3605 19 - - HYPH cord-028721-x6f26ahr 3605 20 fast fast JJ cord-028721-x6f26ahr 3605 21 bacilli bacilli NN cord-028721-x6f26ahr 3605 22 . . . cord-028721-x6f26ahr 3606 1 Most Most JJS cord-028721-x6f26ahr 3606 2 patients patient NNS cord-028721-x6f26ahr 3606 3 with with IN cord-028721-x6f26ahr 3606 4 lepromatous lepromatous JJ cord-028721-x6f26ahr 3606 5 leprosy leprosy NN cord-028721-x6f26ahr 3606 6 are be VBP cord-028721-x6f26ahr 3606 7 infertile infertile JJ cord-028721-x6f26ahr 3606 8 , , , cord-028721-x6f26ahr 3606 9 even even RB cord-028721-x6f26ahr 3606 10 if if IN cord-028721-x6f26ahr 3606 11 the the DT cord-028721-x6f26ahr 3606 12 orchitis orchitis NN cord-028721-x6f26ahr 3606 13 was be VBD cord-028721-x6f26ahr 3606 14 clinically clinically RB cord-028721-x6f26ahr 3606 15 mild mild JJ cord-028721-x6f26ahr 3606 16 . . . cord-028721-x6f26ahr 3607 1 1515 1515 CD cord-028721-x6f26ahr 3607 2 , , , cord-028721-x6f26ahr 3607 3 1516 1516 CD cord-028721-x6f26ahr 3607 4 Brucellosis Brucellosis NNP cord-028721-x6f26ahr 3607 5 Brucellosis Brucellosis NNP cord-028721-x6f26ahr 3607 6 is be VBZ cord-028721-x6f26ahr 3607 7 common common JJ cord-028721-x6f26ahr 3607 8 in in IN cord-028721-x6f26ahr 3607 9 some some DT cord-028721-x6f26ahr 3607 10 parts part NNS cord-028721-x6f26ahr 3607 11 of of IN cord-028721-x6f26ahr 3607 12 the the DT cord-028721-x6f26ahr 3607 13 world world NN cord-028721-x6f26ahr 3607 14 , , , cord-028721-x6f26ahr 3607 15 including include VBG cord-028721-x6f26ahr 3607 16 the the DT cord-028721-x6f26ahr 3607 17 Middle Middle NNP cord-028721-x6f26ahr 3607 18 East East NNP cord-028721-x6f26ahr 3607 19 . . . cord-028721-x6f26ahr 3608 1 1517 1517 CD cord-028721-x6f26ahr 3608 2 , , , cord-028721-x6f26ahr 3608 3 1518 1518 CD cord-028721-x6f26ahr 3608 4 Orchitis Orchitis NNP cord-028721-x6f26ahr 3608 5 occurs occur VBZ cord-028721-x6f26ahr 3608 6 in in IN cord-028721-x6f26ahr 3608 7 some some DT cord-028721-x6f26ahr 3608 8 patients patient NNS cord-028721-x6f26ahr 3608 9 and and CC cord-028721-x6f26ahr 3608 10 may may MD cord-028721-x6f26ahr 3608 11 be be VB cord-028721-x6f26ahr 3608 12 the the DT cord-028721-x6f26ahr 3608 13 fi fi NN cord-028721-x6f26ahr 3608 14 rst rst NN cord-028721-x6f26ahr 3608 15 sign sign NN cord-028721-x6f26ahr 3608 16 of of IN cord-028721-x6f26ahr 3608 17 disease disease NN cord-028721-x6f26ahr 3608 18 . . . cord-028721-x6f26ahr 3609 1 Brucellosis brucellosis NN cord-028721-x6f26ahr 3609 2 should should MD cord-028721-x6f26ahr 3609 3 be be VB cord-028721-x6f26ahr 3609 4 suspected suspect VBN cord-028721-x6f26ahr 3609 5 when when WRB cord-028721-x6f26ahr 3609 6 testicular testicular JJ cord-028721-x6f26ahr 3609 7 enlargement enlargement NN cord-028721-x6f26ahr 3609 8 occurs occur VBZ cord-028721-x6f26ahr 3609 9 in in IN cord-028721-x6f26ahr 3609 10 patients patient NNS cord-028721-x6f26ahr 3609 11 with with IN cord-028721-x6f26ahr 3609 12 undulating undulating JJ cord-028721-x6f26ahr 3609 13 fever fever NN cord-028721-x6f26ahr 3609 14 , , , cord-028721-x6f26ahr 3609 15 malaise malaise NN cord-028721-x6f26ahr 3609 16 , , , cord-028721-x6f26ahr 3609 17 sweats sweat NNS cord-028721-x6f26ahr 3609 18 , , , cord-028721-x6f26ahr 3609 19 weight weight NN cord-028721-x6f26ahr 3609 20 loss loss NN cord-028721-x6f26ahr 3609 21 , , , cord-028721-x6f26ahr 3609 22 and and CC cord-028721-x6f26ahr 3609 23 headache headache NN cord-028721-x6f26ahr 3609 24 . . . cord-028721-x6f26ahr 3610 1 1519 1519 CD cord-028721-x6f26ahr 3611 1 Occasionally occasionally RB cord-028721-x6f26ahr 3611 2 this this DT cord-028721-x6f26ahr 3611 3 may may MD cord-028721-x6f26ahr 3611 4 mimic mimic VB cord-028721-x6f26ahr 3611 5 testicular testicular JJ cord-028721-x6f26ahr 3611 6 tumor tumor NN cord-028721-x6f26ahr 3611 7 . . . cord-028721-x6f26ahr 3612 1 Histologically histologically RB cord-028721-x6f26ahr 3612 2 , , , cord-028721-x6f26ahr 3612 3 there there EX cord-028721-x6f26ahr 3612 4 is be VBZ cord-028721-x6f26ahr 3612 5 a a DT cord-028721-x6f26ahr 3612 6 dense dense JJ cord-028721-x6f26ahr 3612 7 lymphohistiocytic lymphohistiocytic JJ cord-028721-x6f26ahr 3612 8 infl infl NN cord-028721-x6f26ahr 3612 9 ammation ammation NN cord-028721-x6f26ahr 3612 10 with with IN cord-028721-x6f26ahr 3612 11 occasional occasional JJ cord-028721-x6f26ahr 3612 12 non non JJ cord-028721-x6f26ahr 3612 13 - - JJ cord-028721-x6f26ahr 3612 14 caseating caseating JJ cord-028721-x6f26ahr 3612 15 granulomas granuloma NNS cord-028721-x6f26ahr 3612 16 in in IN cord-028721-x6f26ahr 3612 17 the the DT cord-028721-x6f26ahr 3612 18 interstitium interstitium NN cord-028721-x6f26ahr 3612 19 . . . cord-028721-x6f26ahr 3613 1 The the DT cord-028721-x6f26ahr 3613 2 seminiferous seminiferous JJ cord-028721-x6f26ahr 3613 3 tubules tubule NNS cord-028721-x6f26ahr 3613 4 are be VBP cord-028721-x6f26ahr 3613 5 infi infi NNP cord-028721-x6f26ahr 3613 6 ltrated ltrate VBN cord-028721-x6f26ahr 3613 7 by by IN cord-028721-x6f26ahr 3613 8 infl infl NNP cord-028721-x6f26ahr 3613 9 ammatory ammatory NNP cord-028721-x6f26ahr 3613 10 cells cell NNS cord-028721-x6f26ahr 3613 11 and and CC cord-028721-x6f26ahr 3613 12 undergo undergo VB cord-028721-x6f26ahr 3613 13 atrophy atrophy NN cord-028721-x6f26ahr 3613 14 . . . cord-028721-x6f26ahr 3614 1 Diagnosis diagnosis NN cord-028721-x6f26ahr 3614 2 is be VBZ cord-028721-x6f26ahr 3614 3 made make VBN cord-028721-x6f26ahr 3614 4 by by IN cord-028721-x6f26ahr 3614 5 clinical clinical JJ cord-028721-x6f26ahr 3614 6 and and CC cord-028721-x6f26ahr 3614 7 laboratory laboratory NN cord-028721-x6f26ahr 3614 8 fi fi NN cord-028721-x6f26ahr 3614 9 ndings nding NNS cord-028721-x6f26ahr 3614 10 , , , cord-028721-x6f26ahr 3614 11 including include VBG cord-028721-x6f26ahr 3614 12 blood blood NN cord-028721-x6f26ahr 3614 13 culture culture NN cord-028721-x6f26ahr 3614 14 , , , cord-028721-x6f26ahr 3614 15 the the DT cord-028721-x6f26ahr 3614 16 Bengal Bengal NNP cord-028721-x6f26ahr 3614 17 rose rise VBD cord-028721-x6f26ahr 3614 18 test test NN cord-028721-x6f26ahr 3614 19 , , , cord-028721-x6f26ahr 3614 20 and and CC cord-028721-x6f26ahr 3614 21 high high JJ cord-028721-x6f26ahr 3614 22 brucella brucella NN cord-028721-x6f26ahr 3614 23 agglutination agglutination NN cord-028721-x6f26ahr 3614 24 titers titer NNS cord-028721-x6f26ahr 3614 25 , , , cord-028721-x6f26ahr 3614 26 1520 1520 CD cord-028721-x6f26ahr 3614 27 , , , cord-028721-x6f26ahr 3614 28 1521 1521 CD cord-028721-x6f26ahr 3614 29 or or CC cord-028721-x6f26ahr 3614 30 by by IN cord-028721-x6f26ahr 3614 31 real real JJ cord-028721-x6f26ahr 3614 32 - - HYPH cord-028721-x6f26ahr 3614 33 time time NN cord-028721-x6f26ahr 3614 34 polymerase polymerase NN cord-028721-x6f26ahr 3614 35 chain chain NN cord-028721-x6f26ahr 3614 36 reaction reaction NN cord-028721-x6f26ahr 3614 37 assay assay NN cord-028721-x6f26ahr 3614 38 of of IN cord-028721-x6f26ahr 3614 39 urine urine NN cord-028721-x6f26ahr 3614 40 . . . cord-028721-x6f26ahr 3615 1 1522 1522 CD cord-028721-x6f26ahr 3616 1 Sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3616 2 is be VBZ cord-028721-x6f26ahr 3616 3 a a DT cord-028721-x6f26ahr 3616 4 systemic systemic JJ cord-028721-x6f26ahr 3616 5 granulomatous granulomatous JJ cord-028721-x6f26ahr 3616 6 disease disease NN cord-028721-x6f26ahr 3616 7 of of IN cord-028721-x6f26ahr 3616 8 unknown unknown JJ cord-028721-x6f26ahr 3616 9 etiology etiology NN cord-028721-x6f26ahr 3616 10 that that WDT cord-028721-x6f26ahr 3616 11 preferentially preferentially RB cord-028721-x6f26ahr 3616 12 affects affect VBZ cord-028721-x6f26ahr 3616 13 young young JJ cord-028721-x6f26ahr 3616 14 black black JJ cord-028721-x6f26ahr 3616 15 adults adult NNS cord-028721-x6f26ahr 3616 16 . . . cord-028721-x6f26ahr 3617 1 The the DT cord-028721-x6f26ahr 3617 2 genitourinary genitourinary JJ cord-028721-x6f26ahr 3617 3 tract tract NN cord-028721-x6f26ahr 3617 4 is be VBZ cord-028721-x6f26ahr 3617 5 involved involve VBN cord-028721-x6f26ahr 3617 6 in in IN cord-028721-x6f26ahr 3617 7 only only RB cord-028721-x6f26ahr 3617 8 0.5 0.5 CD cord-028721-x6f26ahr 3617 9 % % NN cord-028721-x6f26ahr 3617 10 of of IN cord-028721-x6f26ahr 3617 11 clinical clinical JJ cord-028721-x6f26ahr 3617 12 cases case NNS cord-028721-x6f26ahr 3617 13 and and CC cord-028721-x6f26ahr 3617 14 5 5 CD cord-028721-x6f26ahr 3617 15 % % NN cord-028721-x6f26ahr 3617 16 of of IN cord-028721-x6f26ahr 3617 17 autopsy autopsy JJ cord-028721-x6f26ahr 3617 18 cases case NNS cord-028721-x6f26ahr 3617 19 . . . cord-028721-x6f26ahr 3618 1 Fewer few JJR cord-028721-x6f26ahr 3618 2 than than IN cord-028721-x6f26ahr 3618 3 30 30 CD cord-028721-x6f26ahr 3618 4 cases case NNS cord-028721-x6f26ahr 3618 5 of of IN cord-028721-x6f26ahr 3618 6 primary primary JJ cord-028721-x6f26ahr 3618 7 epididymal epididymal JJ cord-028721-x6f26ahr 3618 8 involvement involvement NN cord-028721-x6f26ahr 3618 9 have have VBP cord-028721-x6f26ahr 3618 10 been be VBN cord-028721-x6f26ahr 3618 11 reported report VBN cord-028721-x6f26ahr 3618 12 , , , cord-028721-x6f26ahr 3618 13 and and CC cord-028721-x6f26ahr 3618 14 about about RB cord-028721-x6f26ahr 3618 15 12 12 CD cord-028721-x6f26ahr 3618 16 of of IN cord-028721-x6f26ahr 3618 17 these these DT cord-028721-x6f26ahr 3618 18 also also RB cord-028721-x6f26ahr 3618 19 involved involve VBD cord-028721-x6f26ahr 3618 20 the the DT cord-028721-x6f26ahr 3618 21 testis testis NN cord-028721-x6f26ahr 3618 22 . . . cord-028721-x6f26ahr 3619 1 1523 1523 CD cord-028721-x6f26ahr 3619 2 , , , cord-028721-x6f26ahr 3619 3 1524 1524 CD cord-028721-x6f26ahr 3619 4 Isolated isolated JJ cord-028721-x6f26ahr 3619 5 testicular testicular JJ cord-028721-x6f26ahr 3619 6 involvement involvement NN cord-028721-x6f26ahr 3619 7 is be VBZ cord-028721-x6f26ahr 3619 8 exceptional exceptional JJ cord-028721-x6f26ahr 3619 9 . . . cord-028721-x6f26ahr 3620 1 1523 1523 CD cord-028721-x6f26ahr 3620 2 , , , cord-028721-x6f26ahr 3620 3 1525 1525 CD cord-028721-x6f26ahr 3621 1 , , , cord-028721-x6f26ahr 3621 2 1526 1526 CD cord-028721-x6f26ahr 3621 3 Testicular testicular JJ cord-028721-x6f26ahr 3621 4 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3621 5 is be VBZ cord-028721-x6f26ahr 3621 6 usually usually RB cord-028721-x6f26ahr 3621 7 unilateral unilateral JJ cord-028721-x6f26ahr 3621 8 and and CC cord-028721-x6f26ahr 3621 9 nodular nodular JJ cord-028721-x6f26ahr 3621 10 . . . cord-028721-x6f26ahr 3622 1 947 947 CD cord-028721-x6f26ahr 3623 1 It -PRON- PRP cord-028721-x6f26ahr 3623 2 is be VBZ cord-028721-x6f26ahr 3623 3 often often RB cord-028721-x6f26ahr 3623 4 asymptomatic asymptomatic JJ cord-028721-x6f26ahr 3623 5 and and CC cord-028721-x6f26ahr 3623 6 found find VBN cord-028721-x6f26ahr 3623 7 at at IN cord-028721-x6f26ahr 3623 8 autopsy autopsy NN cord-028721-x6f26ahr 3623 9 . . . cord-028721-x6f26ahr 3624 1 1527 1527 CD cord-028721-x6f26ahr 3625 1 The the DT cord-028721-x6f26ahr 3625 2 testis testis NN cord-028721-x6f26ahr 3625 3 contains contain VBZ cord-028721-x6f26ahr 3625 4 non non JJ cord-028721-x6f26ahr 3625 5 - - JJ cord-028721-x6f26ahr 3625 6 caseating caseating JJ cord-028721-x6f26ahr 3625 7 granulomas granuloma NNS cord-028721-x6f26ahr 3625 8 similar similar JJ cord-028721-x6f26ahr 3625 9 to to IN cord-028721-x6f26ahr 3625 10 sarcoid sarcoid NNP cord-028721-x6f26ahr 3625 11 granulomas granuloma NNS cord-028721-x6f26ahr 3625 12 at at IN cord-028721-x6f26ahr 3625 13 other other JJ cord-028721-x6f26ahr 3625 14 locations location NNS cord-028721-x6f26ahr 3625 15 . . . cord-028721-x6f26ahr 3626 1 Before before IN cord-028721-x6f26ahr 3626 2 diagnosing diagnose VBG cord-028721-x6f26ahr 3626 3 testicular testicular JJ cord-028721-x6f26ahr 3626 4 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3626 5 , , , cord-028721-x6f26ahr 3626 6 other other JJ cord-028721-x6f26ahr 3626 7 granulomatous granulomatous JJ cord-028721-x6f26ahr 3626 8 lesions lesion NNS cord-028721-x6f26ahr 3626 9 should should MD cord-028721-x6f26ahr 3626 10 be be VB cord-028721-x6f26ahr 3626 11 excluded exclude VBN cord-028721-x6f26ahr 3626 12 , , , cord-028721-x6f26ahr 3626 13 including include VBG cord-028721-x6f26ahr 3626 14 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3626 15 , , , cord-028721-x6f26ahr 3626 16 sperm sperm NN cord-028721-x6f26ahr 3626 17 granuloma granuloma NN cord-028721-x6f26ahr 3626 18 , , , cord-028721-x6f26ahr 3626 19 granulomatous granulomatous JJ cord-028721-x6f26ahr 3626 20 orchitis orchitis NN cord-028721-x6f26ahr 3626 21 , , , cord-028721-x6f26ahr 3626 22 and and CC cord-028721-x6f26ahr 3626 23 seminoma seminoma NN cord-028721-x6f26ahr 3626 24 . . . cord-028721-x6f26ahr 3627 1 Seminoma Seminoma NNP cord-028721-x6f26ahr 3627 2 often often RB cord-028721-x6f26ahr 3627 3 has have VBZ cord-028721-x6f26ahr 3627 4 an an DT cord-028721-x6f26ahr 3627 5 intense intense JJ cord-028721-x6f26ahr 3627 6 sarcoid sarcoid NN cord-028721-x6f26ahr 3627 7 - - HYPH cord-028721-x6f26ahr 3627 8 like like JJ cord-028721-x6f26ahr 3627 9 reaction reaction NN cord-028721-x6f26ahr 3627 10 , , , cord-028721-x6f26ahr 3627 11 and and CC cord-028721-x6f26ahr 3627 12 examination examination NN cord-028721-x6f26ahr 3627 13 of of IN cord-028721-x6f26ahr 3627 14 multiple multiple JJ cord-028721-x6f26ahr 3627 15 histologic histologic JJ cord-028721-x6f26ahr 3627 16 sections section NNS cord-028721-x6f26ahr 3627 17 may may MD cord-028721-x6f26ahr 3627 18 be be VB cord-028721-x6f26ahr 3627 19 necessary necessary JJ cord-028721-x6f26ahr 3627 20 to to TO cord-028721-x6f26ahr 3627 21 fi fi VB cord-028721-x6f26ahr 3627 22 nd nd NNP cord-028721-x6f26ahr 3627 23 diagnostic diagnostic JJ cord-028721-x6f26ahr 3627 24 foci foci NN cord-028721-x6f26ahr 3627 25 of of IN cord-028721-x6f26ahr 3627 26 seminoma seminoma NN cord-028721-x6f26ahr 3627 27 . . . cord-028721-x6f26ahr 3628 1 An an DT cord-028721-x6f26ahr 3628 2 association association NN cord-028721-x6f26ahr 3628 3 of of IN cord-028721-x6f26ahr 3628 4 mediastinal mediastinal NNP cord-028721-x6f26ahr 3628 5 sarcoidosis sarcoidosis NNP cord-028721-x6f26ahr 3628 6 and and CC cord-028721-x6f26ahr 3628 7 testicular testicular JJ cord-028721-x6f26ahr 3628 8 cancer cancer NN cord-028721-x6f26ahr 3628 9 has have VBZ cord-028721-x6f26ahr 3628 10 been be VBN cord-028721-x6f26ahr 3628 11 reported report VBN cord-028721-x6f26ahr 3628 12 . . . cord-028721-x6f26ahr 3629 1 1528 1528 CD cord-028721-x6f26ahr 3629 2 Genital genital JJ cord-028721-x6f26ahr 3629 3 involvement involvement NN cord-028721-x6f26ahr 3629 4 of of IN cord-028721-x6f26ahr 3629 5 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3629 6 may may MD cord-028721-x6f26ahr 3629 7 be be VB cord-028721-x6f26ahr 3629 8 the the DT cord-028721-x6f26ahr 3629 9 cause cause NN cord-028721-x6f26ahr 3629 10 of of IN cord-028721-x6f26ahr 3629 11 intermittent intermittent JJ cord-028721-x6f26ahr 3629 12 azoospermia azoospermia NN cord-028721-x6f26ahr 3629 13 that that WDT cord-028721-x6f26ahr 3629 14 benefi benefi NNP cord-028721-x6f26ahr 3629 15 ts ts NNP cord-028721-x6f26ahr 3629 16 from from IN cord-028721-x6f26ahr 3629 17 corticoid corticoid NNP cord-028721-x6f26ahr 3629 18 therapy therapy NN cord-028721-x6f26ahr 3629 19 . . . cord-028721-x6f26ahr 3630 1 1529 1529 CD cord-028721-x6f26ahr 3631 1 Malakoplakia Malakoplakia NNP cord-028721-x6f26ahr 3631 2 is be VBZ cord-028721-x6f26ahr 3631 3 a a DT cord-028721-x6f26ahr 3631 4 chronic chronic JJ cord-028721-x6f26ahr 3631 5 infl infl NN cord-028721-x6f26ahr 3631 6 ammatory ammatory NN cord-028721-x6f26ahr 3631 7 disease disease NN cord-028721-x6f26ahr 3631 8 that that WDT cord-028721-x6f26ahr 3631 9 was be VBD cord-028721-x6f26ahr 3631 10 initially initially RB cord-028721-x6f26ahr 3631 11 described describe VBN cord-028721-x6f26ahr 3631 12 in in IN cord-028721-x6f26ahr 3631 13 the the DT cord-028721-x6f26ahr 3631 14 bladder bladder NN cord-028721-x6f26ahr 3631 15 1530 1530 CD cord-028721-x6f26ahr 3631 16 and and CC cord-028721-x6f26ahr 3631 17 subsequently subsequently RB cord-028721-x6f26ahr 3631 18 in in IN cord-028721-x6f26ahr 3631 19 many many JJ cord-028721-x6f26ahr 3631 20 other other JJ cord-028721-x6f26ahr 3631 21 organs organ NNS cord-028721-x6f26ahr 3631 22 . . . cord-028721-x6f26ahr 3632 1 The the DT cord-028721-x6f26ahr 3632 2 testes testis NNS cord-028721-x6f26ahr 3632 3 ( ( -LRB- cord-028721-x6f26ahr 3632 4 alone alone RB cord-028721-x6f26ahr 3632 5 or or CC cord-028721-x6f26ahr 3632 6 together together RB cord-028721-x6f26ahr 3632 7 with with IN cord-028721-x6f26ahr 3632 8 the the DT cord-028721-x6f26ahr 3632 9 epididymis epididymis NN cord-028721-x6f26ahr 3632 10 ) ) -RRB- cord-028721-x6f26ahr 3632 11 are be VBP cord-028721-x6f26ahr 3632 12 involved involve VBN cord-028721-x6f26ahr 3632 13 in in IN cord-028721-x6f26ahr 3632 14 12 12 CD cord-028721-x6f26ahr 3632 15 % % NN cord-028721-x6f26ahr 3632 16 of of IN cord-028721-x6f26ahr 3632 17 cases case NNS cord-028721-x6f26ahr 3632 18 involving involve VBG cord-028721-x6f26ahr 3632 19 the the DT cord-028721-x6f26ahr 3632 20 urogenital urogenital JJ cord-028721-x6f26ahr 3632 21 system system NN cord-028721-x6f26ahr 3632 22 . . . cord-028721-x6f26ahr 3633 1 1531 1531 CD cord-028721-x6f26ahr 3633 2 , , , cord-028721-x6f26ahr 3633 3 1532 1532 CD cord-028721-x6f26ahr 3633 4 Grossly grossly RB cord-028721-x6f26ahr 3633 5 , , , cord-028721-x6f26ahr 3633 6 the the DT cord-028721-x6f26ahr 3633 7 testes testis NNS cord-028721-x6f26ahr 3633 8 are be VBP cord-028721-x6f26ahr 3633 9 enlarged enlarge VBN cord-028721-x6f26ahr 3633 10 and and CC cord-028721-x6f26ahr 3633 11 have have VBP cord-028721-x6f26ahr 3633 12 a a DT cord-028721-x6f26ahr 3633 13 brown brown JJ cord-028721-x6f26ahr 3633 14 - - HYPH cord-028721-x6f26ahr 3633 15 yellow yellow JJ cord-028721-x6f26ahr 3633 16 parenchymous parenchymous JJ cord-028721-x6f26ahr 3633 17 discoloration discoloration NN cord-028721-x6f26ahr 3633 18 , , , cord-028721-x6f26ahr 3633 19 1533 1533 CD cord-028721-x6f26ahr 3633 20 often often RB cord-028721-x6f26ahr 3633 21 with with IN cord-028721-x6f26ahr 3633 22 abscesses abscess NNS cord-028721-x6f26ahr 3633 23 . . . cord-028721-x6f26ahr 3634 1 Malakoplakia Malakoplakia NNP cord-028721-x6f26ahr 3634 2 causes cause VBZ cord-028721-x6f26ahr 3634 3 tubular tubular JJ cord-028721-x6f26ahr 3634 4 destruction destruction NN cord-028721-x6f26ahr 3634 5 that that WDT cord-028721-x6f26ahr 3634 6 is be VBZ cord-028721-x6f26ahr 3634 7 associated associate VBN cord-028721-x6f26ahr 3634 8 with with IN cord-028721-x6f26ahr 3634 9 a a DT cord-028721-x6f26ahr 3634 10 dense dense JJ cord-028721-x6f26ahr 3634 11 infi infi NNP cord-028721-x6f26ahr 3634 12 ltrate ltrate NNP cord-028721-x6f26ahr 3634 13 of of IN cord-028721-x6f26ahr 3634 14 macrophages macrophage NNS cord-028721-x6f26ahr 3634 15 with with IN cord-028721-x6f26ahr 3634 16 granular granular JJ cord-028721-x6f26ahr 3634 17 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 3634 18 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3634 19 that that WDT cord-028721-x6f26ahr 3634 20 often often RB cord-028721-x6f26ahr 3634 21 contains contain VBZ cord-028721-x6f26ahr 3634 22 Michaelis Michaelis NNP cord-028721-x6f26ahr 3634 23 - - HYPH cord-028721-x6f26ahr 3634 24 Gutmann Gutmann NNP cord-028721-x6f26ahr 3634 25 bodies body NNS cord-028721-x6f26ahr 3634 26 ( ( -LRB- cord-028721-x6f26ahr 3634 27 Fig Fig NNP cord-028721-x6f26ahr 3634 28 . . . cord-028721-x6f26ahr 3634 29 12 12 CD cord-028721-x6f26ahr 3634 30 - - SYM cord-028721-x6f26ahr 3634 31 160 160 CD cord-028721-x6f26ahr 3634 32 ) ) -RRB- cord-028721-x6f26ahr 3634 33 . . . cord-028721-x6f26ahr 3635 1 1534 1534 CD cord-028721-x6f26ahr 3635 2 , , , cord-028721-x6f26ahr 3635 3 1535 1535 CD cord-028721-x6f26ahr 3636 1 The the DT cord-028721-x6f26ahr 3636 2 differential differential JJ cord-028721-x6f26ahr 3636 3 diagnosis diagnosis NN cord-028721-x6f26ahr 3636 4 includes include VBZ cord-028721-x6f26ahr 3636 5 idiopathic idiopathic JJ cord-028721-x6f26ahr 3636 6 granulomatous granulomatous JJ cord-028721-x6f26ahr 3636 7 orchitis orchitis NN cord-028721-x6f26ahr 3636 8 and and CC cord-028721-x6f26ahr 3636 9 Leydig Leydig NNP cord-028721-x6f26ahr 3636 10 cell cell NN cord-028721-x6f26ahr 3636 11 tumor tumor NN cord-028721-x6f26ahr 3636 12 . . . cord-028721-x6f26ahr 3637 1 Infl Infl NNP cord-028721-x6f26ahr 3637 2 ammation ammation NN cord-028721-x6f26ahr 3637 3 in in IN cord-028721-x6f26ahr 3637 4 idiopathic idiopathic JJ cord-028721-x6f26ahr 3637 5 granulomatous granulomatous JJ cord-028721-x6f26ahr 3637 6 orchitis orchitis NN cord-028721-x6f26ahr 3637 7 includes include VBZ cord-028721-x6f26ahr 3637 8 intratubular intratubular NNP cord-028721-x6f26ahr 3637 9 multinucleate multinucleate NNP cord-028721-x6f26ahr 3637 10 giant giant JJ cord-028721-x6f26ahr 3637 11 cells cell NNS cord-028721-x6f26ahr 3637 12 ; ; : cord-028721-x6f26ahr 3637 13 in in IN cord-028721-x6f26ahr 3637 14 malakoplakia malakoplakia NN cord-028721-x6f26ahr 3637 15 it -PRON- PRP cord-028721-x6f26ahr 3637 16 is be VBZ cord-028721-x6f26ahr 3637 17 diffi diffi JJ cord-028721-x6f26ahr 3637 18 cult cult NN cord-028721-x6f26ahr 3637 19 to to TO cord-028721-x6f26ahr 3637 20 identify identify VB cord-028721-x6f26ahr 3637 21 the the DT cord-028721-x6f26ahr 3637 22 tubular tubular JJ cord-028721-x6f26ahr 3637 23 outlines outline NNS cord-028721-x6f26ahr 3637 24 , , , cord-028721-x6f26ahr 3637 25 and and CC cord-028721-x6f26ahr 3637 26 giant giant JJ cord-028721-x6f26ahr 3637 27 cells cell NNS cord-028721-x6f26ahr 3637 28 are be VBP cord-028721-x6f26ahr 3637 29 usually usually RB cord-028721-x6f26ahr 3637 30 absent absent JJ cord-028721-x6f26ahr 3637 31 . . . cord-028721-x6f26ahr 3638 1 Leydig leydig NN cord-028721-x6f26ahr 3638 2 cell cell NN cord-028721-x6f26ahr 3638 3 tumor tumor NN cord-028721-x6f26ahr 3638 4 is be VBZ cord-028721-x6f26ahr 3638 5 not not RB cord-028721-x6f26ahr 3638 6 usually usually RB cord-028721-x6f26ahr 3638 7 associated associate VBN cord-028721-x6f26ahr 3638 8 with with IN cord-028721-x6f26ahr 3638 9 infl infl NN cord-028721-x6f26ahr 3638 10 ammation ammation NN cord-028721-x6f26ahr 3638 11 , , , cord-028721-x6f26ahr 3638 12 but but CC cord-028721-x6f26ahr 3638 13 may may MD cord-028721-x6f26ahr 3638 14 contain contain VB cord-028721-x6f26ahr 3638 15 mononucleated mononucleated JJ cord-028721-x6f26ahr 3638 16 or or CC cord-028721-x6f26ahr 3638 17 binucleated binucleate VBN cord-028721-x6f26ahr 3638 18 cells cell NNS cord-028721-x6f26ahr 3638 19 with with IN cord-028721-x6f26ahr 3638 20 abundant abundant JJ cord-028721-x6f26ahr 3638 21 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 3638 22 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3638 23 . . . cord-028721-x6f26ahr 3639 1 Reinke Reinke NNP cord-028721-x6f26ahr 3639 2 's 's POS cord-028721-x6f26ahr 3639 3 crystalloids crystalloid NNS cord-028721-x6f26ahr 3639 4 are be VBP cord-028721-x6f26ahr 3639 5 identifi identifi VBN cord-028721-x6f26ahr 3639 6 ed ed NN cord-028721-x6f26ahr 3639 7 in in RP cord-028721-x6f26ahr 3639 8 up up IN cord-028721-x6f26ahr 3639 9 to to TO cord-028721-x6f26ahr 3639 10 40 40 CD cord-028721-x6f26ahr 3639 11 % % NN cord-028721-x6f26ahr 3639 12 of of IN cord-028721-x6f26ahr 3639 13 cases case NNS cord-028721-x6f26ahr 3639 14 of of IN cord-028721-x6f26ahr 3639 15 Leydig Leydig NNP cord-028721-x6f26ahr 3639 16 cell cell NN cord-028721-x6f26ahr 3639 17 tumor tumor NN cord-028721-x6f26ahr 3639 18 but but CC cord-028721-x6f26ahr 3639 19 absent absent JJ cord-028721-x6f26ahr 3639 20 in in IN cord-028721-x6f26ahr 3639 21 malakoplakia malakoplakia NN cord-028721-x6f26ahr 3639 22 , , , cord-028721-x6f26ahr 3639 23 and and CC cord-028721-x6f26ahr 3639 24 Michaelis Michaelis NNP cord-028721-x6f26ahr 3639 25 - - HYPH cord-028721-x6f26ahr 3639 26 Gutmann Gutmann NNP cord-028721-x6f26ahr 3639 27 bodies body NNS cord-028721-x6f26ahr 3639 28 are be VBP cord-028721-x6f26ahr 3639 29 absent absent JJ cord-028721-x6f26ahr 3639 30 . . . cord-028721-x6f26ahr 3640 1 Fungal fungal JJ cord-028721-x6f26ahr 3640 2 orchitis orchitis NN cord-028721-x6f26ahr 3640 3 is be VBZ cord-028721-x6f26ahr 3640 4 rare rare JJ cord-028721-x6f26ahr 3640 5 ; ; : cord-028721-x6f26ahr 3640 6 most most JJS cord-028721-x6f26ahr 3640 7 cases case NNS cord-028721-x6f26ahr 3640 8 are be VBP cord-028721-x6f26ahr 3640 9 associated associate VBN cord-028721-x6f26ahr 3640 10 with with IN cord-028721-x6f26ahr 3640 11 blastomycosis blastomycosis NNP cord-028721-x6f26ahr 3640 12 , , , cord-028721-x6f26ahr 3640 13 coccidiomycosis coccidiomycosis NN cord-028721-x6f26ahr 3640 14 , , , cord-028721-x6f26ahr 3640 15 histoplasmosis histoplasmosis NN cord-028721-x6f26ahr 3640 16 , , , cord-028721-x6f26ahr 3640 17 and and CC cord-028721-x6f26ahr 3640 18 cryptococcocis cryptococcoci NNS cord-028721-x6f26ahr 3640 19 . . . cord-028721-x6f26ahr 3641 1 1536 1536 CD cord-028721-x6f26ahr 3642 1 The the DT cord-028721-x6f26ahr 3642 2 genital genital JJ cord-028721-x6f26ahr 3642 3 tract tract NN cord-028721-x6f26ahr 3642 4 may may MD cord-028721-x6f26ahr 3642 5 be be VB cord-028721-x6f26ahr 3642 6 involved involve VBN cord-028721-x6f26ahr 3642 7 in in IN cord-028721-x6f26ahr 3642 8 widespread widespread JJ cord-028721-x6f26ahr 3642 9 blastomycosis blastomycosis NN cord-028721-x6f26ahr 3642 10 . . . cord-028721-x6f26ahr 3643 1 In in IN cord-028721-x6f26ahr 3643 2 decreasing decrease VBG cord-028721-x6f26ahr 3643 3 order order NN cord-028721-x6f26ahr 3643 4 , , , cord-028721-x6f26ahr 3643 5 the the DT cord-028721-x6f26ahr 3643 6 organs organ NNS cord-028721-x6f26ahr 3643 7 most most RBS cord-028721-x6f26ahr 3643 8 frequently frequently RB cord-028721-x6f26ahr 3643 9 affected affect VBN cord-028721-x6f26ahr 3643 10 are be VBP cord-028721-x6f26ahr 3643 11 the the DT cord-028721-x6f26ahr 3643 12 prostate prostate NN cord-028721-x6f26ahr 3643 13 , , , cord-028721-x6f26ahr 3643 14 epididymis epididymis NN cord-028721-x6f26ahr 3643 15 , , , cord-028721-x6f26ahr 3643 16 testis testis NN cord-028721-x6f26ahr 3643 17 , , , cord-028721-x6f26ahr 3643 18 and and CC cord-028721-x6f26ahr 3643 19 seminal seminal JJ cord-028721-x6f26ahr 3643 20 vesicles vesicle NNS cord-028721-x6f26ahr 3643 21 . . . cord-028721-x6f26ahr 3644 1 Grossly grossly RB cord-028721-x6f26ahr 3644 2 , , , cord-028721-x6f26ahr 3644 3 there there EX cord-028721-x6f26ahr 3644 4 often often RB cord-028721-x6f26ahr 3644 5 are be VBP cord-028721-x6f26ahr 3644 6 small small JJ cord-028721-x6f26ahr 3644 7 abscesses abscess NNS cord-028721-x6f26ahr 3644 8 that that WDT cord-028721-x6f26ahr 3644 9 may may MD cord-028721-x6f26ahr 3644 10 have have VB cord-028721-x6f26ahr 3644 11 caseous caseous JJ cord-028721-x6f26ahr 3644 12 centers center NNS cord-028721-x6f26ahr 3644 13 . . . cord-028721-x6f26ahr 3645 1 Fungi fungi NN cord-028721-x6f26ahr 3645 2 measuring measure VBG cord-028721-x6f26ahr 3645 3 8 8 CD cord-028721-x6f26ahr 3645 4 - - SYM cord-028721-x6f26ahr 3645 5 15 15 CD cord-028721-x6f26ahr 3645 6 µm µm NN cord-028721-x6f26ahr 3645 7 in in IN cord-028721-x6f26ahr 3645 8 diameter diameter NN cord-028721-x6f26ahr 3645 9 with with IN cord-028721-x6f26ahr 3645 10 double double JJ cord-028721-x6f26ahr 3645 11 refringent refringent NN cord-028721-x6f26ahr 3645 12 contours contour NNS cord-028721-x6f26ahr 3645 13 are be VBP cord-028721-x6f26ahr 3645 14 present present JJ cord-028721-x6f26ahr 3645 15 in in IN cord-028721-x6f26ahr 3645 16 the the DT cord-028721-x6f26ahr 3645 17 giant giant JJ cord-028721-x6f26ahr 3645 18 cells cell NNS cord-028721-x6f26ahr 3645 19 in in IN cord-028721-x6f26ahr 3645 20 granulomas granuloma NNS cord-028721-x6f26ahr 3645 21 and and CC cord-028721-x6f26ahr 3645 22 stain stain VBP cord-028721-x6f26ahr 3645 23 positively positively RB cord-028721-x6f26ahr 3645 24 with with IN cord-028721-x6f26ahr 3645 25 periodic periodic JJ cord-028721-x6f26ahr 3645 26 acid acid NN cord-028721-x6f26ahr 3645 27 - - HYPH cord-028721-x6f26ahr 3645 28 Schiff Schiff NNP cord-028721-x6f26ahr 3645 29 and and CC cord-028721-x6f26ahr 3645 30 methenamine methenamine JJ cord-028721-x6f26ahr 3645 31 silver silver JJ cord-028721-x6f26ahr 3645 32 stains stain NNS cord-028721-x6f26ahr 3645 33 . . . cord-028721-x6f26ahr 3646 1 Coccidioidomycosis Coccidioidomycosis NNP cord-028721-x6f26ahr 3646 2 is be VBZ cord-028721-x6f26ahr 3646 3 endemic endemic JJ cord-028721-x6f26ahr 3646 4 in in IN cord-028721-x6f26ahr 3646 5 California California NNP cord-028721-x6f26ahr 3646 6 , , , cord-028721-x6f26ahr 3646 7 the the DT cord-028721-x6f26ahr 3646 8 southwestern southwestern JJ cord-028721-x6f26ahr 3646 9 United United NNP cord-028721-x6f26ahr 3646 10 States States NNP cord-028721-x6f26ahr 3646 11 , , , cord-028721-x6f26ahr 3646 12 and and CC cord-028721-x6f26ahr 3646 13 Mexico Mexico NNP cord-028721-x6f26ahr 3646 14 , , , cord-028721-x6f26ahr 3646 15 and and CC cord-028721-x6f26ahr 3646 16 may may MD cord-028721-x6f26ahr 3646 17 present present VB cord-028721-x6f26ahr 3646 18 as as IN cord-028721-x6f26ahr 3646 19 epididymal epididymal JJ cord-028721-x6f26ahr 3646 20 disease disease NN cord-028721-x6f26ahr 3646 21 after after IN cord-028721-x6f26ahr 3646 22 remission remission NN cord-028721-x6f26ahr 3646 23 of of IN cord-028721-x6f26ahr 3646 24 systemic systemic JJ cord-028721-x6f26ahr 3646 25 symptoms symptom NNS cord-028721-x6f26ahr 3646 26 . . . cord-028721-x6f26ahr 3647 1 1537 1537 CD cord-028721-x6f26ahr 3647 2 The the DT cord-028721-x6f26ahr 3647 3 granulomas granuloma NNS cord-028721-x6f26ahr 3647 4 are be VBP cord-028721-x6f26ahr 3647 5 similar similar JJ cord-028721-x6f26ahr 3647 6 to to IN cord-028721-x6f26ahr 3647 7 those those DT cord-028721-x6f26ahr 3647 8 of of IN cord-028721-x6f26ahr 3647 9 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3647 10 and and CC cord-028721-x6f26ahr 3647 11 contain contain VBP cord-028721-x6f26ahr 3647 12 30 30 CD cord-028721-x6f26ahr 3647 13 - - SYM cord-028721-x6f26ahr 3647 14 60 60 CD cord-028721-x6f26ahr 3647 15 µm µm NN cord-028721-x6f26ahr 3647 16 sporangia sporangium NNS cord-028721-x6f26ahr 3647 17 with with IN cord-028721-x6f26ahr 3647 18 endospores endospore NNS cord-028721-x6f26ahr 3647 19 that that WDT cord-028721-x6f26ahr 3647 20 stain stain VBP cord-028721-x6f26ahr 3647 21 with with IN cord-028721-x6f26ahr 3647 22 periodic periodic JJ cord-028721-x6f26ahr 3647 23 acid acid NN cord-028721-x6f26ahr 3647 24 - - HYPH cord-028721-x6f26ahr 3647 25 Schiff Schiff NNP cord-028721-x6f26ahr 3647 26 . . . cord-028721-x6f26ahr 3648 1 Dissemination dissemination NN cord-028721-x6f26ahr 3648 2 of of IN cord-028721-x6f26ahr 3648 3 histoplasmosis histoplasmosis NN cord-028721-x6f26ahr 3648 4 and and CC cord-028721-x6f26ahr 3648 5 cryptococcosis cryptococcosis NN cord-028721-x6f26ahr 3648 6 frequently frequently RB cord-028721-x6f26ahr 3648 7 occurs occur VBZ cord-028721-x6f26ahr 3648 8 after after IN cord-028721-x6f26ahr 3648 9 steroid steroid NN cord-028721-x6f26ahr 3648 10 therapy therapy NN cord-028721-x6f26ahr 3648 11 and and CC cord-028721-x6f26ahr 3648 12 may may MD cord-028721-x6f26ahr 3648 13 give give VB cord-028721-x6f26ahr 3648 14 rise rise NN cord-028721-x6f26ahr 3648 15 to to IN cord-028721-x6f26ahr 3648 16 granulomatous granulomatous JJ cord-028721-x6f26ahr 3648 17 orchitis orchitis NN cord-028721-x6f26ahr 3648 18 with with IN cord-028721-x6f26ahr 3648 19 extensive extensive JJ cord-028721-x6f26ahr 3648 20 necrosis necrosis NN cord-028721-x6f26ahr 3648 21 . . . cord-028721-x6f26ahr 3649 1 1538 1538 CD cord-028721-x6f26ahr 3650 1 Histoplasma Histoplasma NNP cord-028721-x6f26ahr 3650 2 capsulatum capsulatum NN cord-028721-x6f26ahr 3650 3 measures measure VBZ cord-028721-x6f26ahr 3650 4 1 1 CD cord-028721-x6f26ahr 3650 5 - - SYM cord-028721-x6f26ahr 3650 6 5 5 CD cord-028721-x6f26ahr 3650 7 µm µm NN cord-028721-x6f26ahr 3650 8 in in IN cord-028721-x6f26ahr 3650 9 diameter diameter NN cord-028721-x6f26ahr 3650 10 and and CC cord-028721-x6f26ahr 3650 11 may may MD cord-028721-x6f26ahr 3650 12 be be VB cord-028721-x6f26ahr 3650 13 demonstrated demonstrate VBN cord-028721-x6f26ahr 3650 14 with with IN cord-028721-x6f26ahr 3650 15 silver silver JJ cord-028721-x6f26ahr 3650 16 stain stain NN cord-028721-x6f26ahr 3650 17 . . . cord-028721-x6f26ahr 3651 1 Cryptococcus Cryptococcus NNP cord-028721-x6f26ahr 3651 2 is be VBZ cord-028721-x6f26ahr 3651 3 identifi identifi VBN cord-028721-x6f26ahr 3651 4 ed ed NN cord-028721-x6f26ahr 3651 5 by by IN cord-028721-x6f26ahr 3651 6 its -PRON- PRP$ cord-028721-x6f26ahr 3651 7 thick thick JJ cord-028721-x6f26ahr 3651 8 wall wall NN cord-028721-x6f26ahr 3651 9 that that WDT cord-028721-x6f26ahr 3651 10 stains stain VBZ cord-028721-x6f26ahr 3651 11 with with IN cord-028721-x6f26ahr 3651 12 mucicarmine mucicarmine NN cord-028721-x6f26ahr 3651 13 . . . cord-028721-x6f26ahr 3652 1 Most Most JJS cord-028721-x6f26ahr 3652 2 parasites parasite NNS cord-028721-x6f26ahr 3652 3 that that WDT cord-028721-x6f26ahr 3652 4 reach reach VBP cord-028721-x6f26ahr 3652 5 the the DT cord-028721-x6f26ahr 3652 6 genital genital JJ cord-028721-x6f26ahr 3652 7 tract tract NN cord-028721-x6f26ahr 3652 8 , , , cord-028721-x6f26ahr 3652 9 such such JJ cord-028721-x6f26ahr 3652 10 as as IN cord-028721-x6f26ahr 3652 11 Phyllaria Phyllaria NNP cord-028721-x6f26ahr 3652 12 and and CC cord-028721-x6f26ahr 3652 13 Schistosoma Schistosoma NNP cord-028721-x6f26ahr 3652 14 , , , cord-028721-x6f26ahr 3652 15 are be VBP cord-028721-x6f26ahr 3652 16 in in IN cord-028721-x6f26ahr 3652 17 the the DT cord-028721-x6f26ahr 3652 18 spermatic spermatic JJ cord-028721-x6f26ahr 3652 19 cord cord NN cord-028721-x6f26ahr 3652 20 , , , cord-028721-x6f26ahr 3652 21 and and CC cord-028721-x6f26ahr 3652 22 testicular testicular JJ cord-028721-x6f26ahr 3652 23 lesions lesion NNS cord-028721-x6f26ahr 3652 24 are be VBP cord-028721-x6f26ahr 3652 25 secondary secondary JJ cord-028721-x6f26ahr 3652 26 to to IN cord-028721-x6f26ahr 3652 27 vascular vascular JJ cord-028721-x6f26ahr 3652 28 injury injury NN cord-028721-x6f26ahr 3652 29 . . . cord-028721-x6f26ahr 3653 1 1539 1539 CD cord-028721-x6f26ahr 3653 2 Testicular testicular JJ cord-028721-x6f26ahr 3653 3 infection infection NN cord-028721-x6f26ahr 3653 4 has have VBZ cord-028721-x6f26ahr 3653 5 also also RB cord-028721-x6f26ahr 3653 6 been be VBN cord-028721-x6f26ahr 3653 7 reported report VBN cord-028721-x6f26ahr 3653 8 in in IN cord-028721-x6f26ahr 3653 9 patients patient NNS cord-028721-x6f26ahr 3653 10 with with IN cord-028721-x6f26ahr 3653 11 visceral visceral JJ cord-028721-x6f26ahr 3653 12 leishmaniasis leishmaniasis NN cord-028721-x6f26ahr 3653 13 , , , cord-028721-x6f26ahr 3653 14 congenital congenital JJ cord-028721-x6f26ahr 3653 15 and and CC cord-028721-x6f26ahr 3653 16 acquired acquire VBN cord-028721-x6f26ahr 3653 17 toxoplasmosis toxoplasmosi NNS cord-028721-x6f26ahr 3653 18 ( ( -LRB- cord-028721-x6f26ahr 3653 19 Fig Fig NNP cord-028721-x6f26ahr 3653 20 . . . cord-028721-x6f26ahr 3653 21 _SP cord-028721-x6f26ahr 3654 1 12 12 CD cord-028721-x6f26ahr 3654 2 - - SYM cord-028721-x6f26ahr 3654 3 161 161 CD cord-028721-x6f26ahr 3654 4 ) ) -RRB- cord-028721-x6f26ahr 3654 5 , , , cord-028721-x6f26ahr 3654 6 1540 1540 CD cord-028721-x6f26ahr 3654 7 Echinococcus Echinococcus NNP cord-028721-x6f26ahr 3654 8 infection infection NN cord-028721-x6f26ahr 3654 9 , , , cord-028721-x6f26ahr 3654 10 1541 1541 CD cord-028721-x6f26ahr 3654 11 and and CC cord-028721-x6f26ahr 3654 12 orchitis orchitis NN cord-028721-x6f26ahr 3654 13 due due JJ cord-028721-x6f26ahr 3654 14 to to IN cord-028721-x6f26ahr 3654 15 Trichomonas Trichomonas NNP cord-028721-x6f26ahr 3654 16 vaginalis vaginalis NN cord-028721-x6f26ahr 3654 17 . . . cord-028721-x6f26ahr 3654 18 _SP cord-028721-x6f26ahr 3655 1 Idiopathic idiopathic JJ cord-028721-x6f26ahr 3655 2 granulomatous granulomatous JJ cord-028721-x6f26ahr 3655 3 orchitis orchitis NN cord-028721-x6f26ahr 3655 4 is be VBZ cord-028721-x6f26ahr 3655 5 a a DT cord-028721-x6f26ahr 3655 6 chronic chronic JJ cord-028721-x6f26ahr 3655 7 infl infl NN cord-028721-x6f26ahr 3655 8 ammatory ammatory NN cord-028721-x6f26ahr 3655 9 condition condition NN cord-028721-x6f26ahr 3655 10 of of IN cord-028721-x6f26ahr 3655 11 older old JJR cord-028721-x6f26ahr 3655 12 adults adult NNS cord-028721-x6f26ahr 3655 13 ( ( -LRB- cord-028721-x6f26ahr 3655 14 mean mean UH cord-028721-x6f26ahr 3655 15 , , , cord-028721-x6f26ahr 3655 16 59.2 59.2 CD cord-028721-x6f26ahr 3655 17 years year NNS cord-028721-x6f26ahr 3655 18 ) ) -RRB- cord-028721-x6f26ahr 3655 19 . . . cord-028721-x6f26ahr 3656 1 The the DT cord-028721-x6f26ahr 3656 2 most most RBS cord-028721-x6f26ahr 3656 3 prominent prominent JJ cord-028721-x6f26ahr 3656 4 clinical clinical JJ cord-028721-x6f26ahr 3656 5 symptom symptom NN cord-028721-x6f26ahr 3656 6 is be VBZ cord-028721-x6f26ahr 3656 7 testicular testicular JJ cord-028721-x6f26ahr 3656 8 enlargement enlargement NN cord-028721-x6f26ahr 3656 9 , , , cord-028721-x6f26ahr 3656 10 suggesting suggest VBG cord-028721-x6f26ahr 3656 11 malignancy malignancy NN cord-028721-x6f26ahr 3656 12 . . . cord-028721-x6f26ahr 3657 1 1542 1542 CD cord-028721-x6f26ahr 3658 1 Most Most JJS cord-028721-x6f26ahr 3658 2 patients patient NNS cord-028721-x6f26ahr 3658 3 have have VBP cord-028721-x6f26ahr 3658 4 a a DT cord-028721-x6f26ahr 3658 5 history history NN cord-028721-x6f26ahr 3658 6 of of IN cord-028721-x6f26ahr 3658 7 scrotal scrotal JJ cord-028721-x6f26ahr 3658 8 trauma trauma NN cord-028721-x6f26ahr 3658 9 , , , cord-028721-x6f26ahr 3658 10 66 66 CD cord-028721-x6f26ahr 3658 11 % % NN cord-028721-x6f26ahr 3658 12 have have VBP cord-028721-x6f26ahr 3658 13 symptoms symptom NNS cord-028721-x6f26ahr 3658 14 of of IN cord-028721-x6f26ahr 3658 15 urinary urinary JJ cord-028721-x6f26ahr 3658 16 tract tract NN cord-028721-x6f26ahr 3658 17 infection infection NN cord-028721-x6f26ahr 3658 18 with with IN cord-028721-x6f26ahr 3658 19 negative negative JJ cord-028721-x6f26ahr 3658 20 cultures culture NNS cord-028721-x6f26ahr 3658 21 , , , cord-028721-x6f26ahr 3658 22 and and CC cord-028721-x6f26ahr 3658 23 40 40 CD cord-028721-x6f26ahr 3658 24 % % NN cord-028721-x6f26ahr 3658 25 have have VBP cord-028721-x6f26ahr 3658 26 sperm sperm NN cord-028721-x6f26ahr 3658 27 granuloma granuloma NN cord-028721-x6f26ahr 3658 28 in in IN cord-028721-x6f26ahr 3658 29 the the DT cord-028721-x6f26ahr 3658 30 epididymis epididymis NN cord-028721-x6f26ahr 3658 31 . . . cord-028721-x6f26ahr 3659 1 An an DT cord-028721-x6f26ahr 3659 2 autoimmune autoimmune JJ cord-028721-x6f26ahr 3659 3 etiology etiology NN cord-028721-x6f26ahr 3659 4 has have VBZ cord-028721-x6f26ahr 3659 5 been be VBN cord-028721-x6f26ahr 3659 6 suggested suggest VBN cord-028721-x6f26ahr 3659 7 . . . cord-028721-x6f26ahr 3660 1 The the DT cord-028721-x6f26ahr 3660 2 testis testis NN cord-028721-x6f26ahr 3660 3 is be VBZ cord-028721-x6f26ahr 3660 4 enlarged enlarge VBN cord-028721-x6f26ahr 3660 5 , , , cord-028721-x6f26ahr 3660 6 with with IN cord-028721-x6f26ahr 3660 7 a a DT cord-028721-x6f26ahr 3660 8 nodular nodular JJ cord-028721-x6f26ahr 3660 9 cut cut NN cord-028721-x6f26ahr 3660 10 surface surface NN cord-028721-x6f26ahr 3660 11 and and CC cord-028721-x6f26ahr 3660 12 areas area NNS cord-028721-x6f26ahr 3660 13 of of IN cord-028721-x6f26ahr 3660 14 necrosis necrosis NN cord-028721-x6f26ahr 3660 15 or or CC cord-028721-x6f26ahr 3660 16 infarction infarction NN cord-028721-x6f26ahr 3660 17 . . . cord-028721-x6f26ahr 3661 1 There there EX cord-028721-x6f26ahr 3661 2 are be VBP cord-028721-x6f26ahr 3661 3 two two CD cord-028721-x6f26ahr 3661 4 histologic histologic JJ cord-028721-x6f26ahr 3661 5 forms form NNS cord-028721-x6f26ahr 3661 6 , , , cord-028721-x6f26ahr 3661 7 according accord VBG cord-028721-x6f26ahr 3661 8 to to IN cord-028721-x6f26ahr 3661 9 whether whether IN cord-028721-x6f26ahr 3661 10 the the DT cord-028721-x6f26ahr 3661 11 lesion lesion NN cord-028721-x6f26ahr 3661 12 is be VBZ cord-028721-x6f26ahr 3661 13 predominantly predominantly RB cord-028721-x6f26ahr 3661 14 in in IN cord-028721-x6f26ahr 3661 15 the the DT cord-028721-x6f26ahr 3661 16 tubules tubule NNS cord-028721-x6f26ahr 3661 17 ( ( -LRB- cord-028721-x6f26ahr 3661 18 tubular tubular JJ cord-028721-x6f26ahr 3661 19 orchitis orchitis NN cord-028721-x6f26ahr 3661 20 ) ) -RRB- cord-028721-x6f26ahr 3661 21 or or CC cord-028721-x6f26ahr 3661 22 the the DT cord-028721-x6f26ahr 3661 23 interstitium interstitium JJ cord-028721-x6f26ahr 3661 24 ( ( -LRB- cord-028721-x6f26ahr 3661 25 interstitial interstitial JJ cord-028721-x6f26ahr 3661 26 orchitis orchitis NN cord-028721-x6f26ahr 3661 27 ) ) -RRB- cord-028721-x6f26ahr 3661 28 . . . cord-028721-x6f26ahr 3662 1 In in IN cord-028721-x6f26ahr 3662 2 tubular tubular JJ cord-028721-x6f26ahr 3662 3 orchitis orchitis NN cord-028721-x6f26ahr 3662 4 , , , cord-028721-x6f26ahr 3662 5 germ germ NN cord-028721-x6f26ahr 3662 6 cells cell NNS cord-028721-x6f26ahr 3662 7 degenerate degenerate VBP cord-028721-x6f26ahr 3662 8 and and CC cord-028721-x6f26ahr 3662 9 the the DT cord-028721-x6f26ahr 3662 10 Sertoli Sertoli NNP cord-028721-x6f26ahr 3662 11 cells cell NNS cord-028721-x6f26ahr 3662 12 have have VBP cord-028721-x6f26ahr 3662 13 vacuolated vacuolate VBN cord-028721-x6f26ahr 3662 14 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3662 15 and and CC cord-028721-x6f26ahr 3662 16 vesicular vesicular JJ cord-028721-x6f26ahr 3662 17 nuclei nucleus NNS cord-028721-x6f26ahr 3662 18 . . . cord-028721-x6f26ahr 3663 1 Plasma plasma NN cord-028721-x6f26ahr 3663 2 cells cell NNS cord-028721-x6f26ahr 3663 3 and and CC cord-028721-x6f26ahr 3663 4 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3663 5 infi infi NNP cord-028721-x6f26ahr 3663 6 ltrate ltrate NNP cord-028721-x6f26ahr 3663 7 the the DT cord-028721-x6f26ahr 3663 8 walls wall NNS cord-028721-x6f26ahr 3663 9 of of IN cord-028721-x6f26ahr 3663 10 the the DT cord-028721-x6f26ahr 3663 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 3663 12 tubules tubule NNS cord-028721-x6f26ahr 3663 13 , , , cord-028721-x6f26ahr 3663 14 forming form VBG cord-028721-x6f26ahr 3663 15 concentric concentric JJ cord-028721-x6f26ahr 3663 16 rings ring NNS cord-028721-x6f26ahr 3663 17 . . . cord-028721-x6f26ahr 3664 1 Multinucleated multinucleated JJ cord-028721-x6f26ahr 3664 2 giant giant JJ cord-028721-x6f26ahr 3664 3 cells cell NNS cord-028721-x6f26ahr 3664 4 are be VBP cord-028721-x6f26ahr 3664 5 present present JJ cord-028721-x6f26ahr 3664 6 in in IN cord-028721-x6f26ahr 3664 7 the the DT cord-028721-x6f26ahr 3664 8 tubular tubular JJ cord-028721-x6f26ahr 3664 9 lumina lumina NN cord-028721-x6f26ahr 3664 10 and and CC cord-028721-x6f26ahr 3664 11 sometimes sometimes RB cord-028721-x6f26ahr 3664 12 in in IN cord-028721-x6f26ahr 3664 13 the the DT cord-028721-x6f26ahr 3664 14 interstitium interstitium NN cord-028721-x6f26ahr 3665 1 ( ( -LRB- cord-028721-x6f26ahr 3665 2 Fig Fig NNP cord-028721-x6f26ahr 3665 3 . . . cord-028721-x6f26ahr 3665 4 12 12 CD cord-028721-x6f26ahr 3665 5 - - SYM cord-028721-x6f26ahr 3665 6 162 162 CD cord-028721-x6f26ahr 3665 7 ) ) -RRB- cord-028721-x6f26ahr 3665 8 . . . cord-028721-x6f26ahr 3666 1 Vascular vascular JJ cord-028721-x6f26ahr 3666 2 thrombosis thrombosis NN cord-028721-x6f26ahr 3666 3 and and CC cord-028721-x6f26ahr 3666 4 arteritis arteritis NN cord-028721-x6f26ahr 3666 5 are be VBP cord-028721-x6f26ahr 3666 6 common common JJ cord-028721-x6f26ahr 3666 7 . . . cord-028721-x6f26ahr 3667 1 In in IN cord-028721-x6f26ahr 3667 2 interstitial interstitial JJ cord-028721-x6f26ahr 3667 3 orchitis orchitis NN cord-028721-x6f26ahr 3667 4 , , , cord-028721-x6f26ahr 3667 5 the the DT cord-028721-x6f26ahr 3667 6 infl infl NN cord-028721-x6f26ahr 3667 7 ammation ammation NNP cord-028721-x6f26ahr 3667 8 is be VBZ cord-028721-x6f26ahr 3667 9 predominantly predominantly RB cord-028721-x6f26ahr 3667 10 interstitial interstitial JJ cord-028721-x6f26ahr 3667 11 . . . cord-028721-x6f26ahr 3668 1 Ultimately ultimately RB cord-028721-x6f26ahr 3668 2 , , , cord-028721-x6f26ahr 3668 3 tubular tubular JJ cord-028721-x6f26ahr 3668 4 atrophy atrophy NN cord-028721-x6f26ahr 3668 5 and and CC cord-028721-x6f26ahr 3668 6 interstitial interstitial NN cord-028721-x6f26ahr 3668 7 fi fi NN cord-028721-x6f26ahr 3668 8 brosis brosis NN cord-028721-x6f26ahr 3668 9 prevail prevail VBP cord-028721-x6f26ahr 3668 10 in in IN cord-028721-x6f26ahr 3668 11 both both DT cord-028721-x6f26ahr 3668 12 forms form NNS cord-028721-x6f26ahr 3668 13 , , , cord-028721-x6f26ahr 3668 14 which which WDT cord-028721-x6f26ahr 3668 15 may may MD cord-028721-x6f26ahr 3668 16 arise arise VB cord-028721-x6f26ahr 3668 17 from from IN cord-028721-x6f26ahr 3668 18 different different JJ cord-028721-x6f26ahr 3668 19 immune immune JJ cord-028721-x6f26ahr 3668 20 mechanisms mechanism NNS cord-028721-x6f26ahr 3668 21 . . . cord-028721-x6f26ahr 3669 1 1543 1543 CD cord-028721-x6f26ahr 3670 1 Tubular tubular JJ cord-028721-x6f26ahr 3670 2 orchitis orchitis NN cord-028721-x6f26ahr 3670 3 histologically histologically RB cord-028721-x6f26ahr 3670 4 resembles resemble VBZ cord-028721-x6f26ahr 3670 5 experimental experimental JJ cord-028721-x6f26ahr 3670 6 orchitis orchitis NN cord-028721-x6f26ahr 3670 7 caused cause VBN cord-028721-x6f26ahr 3670 8 by by IN cord-028721-x6f26ahr 3670 9 injection injection NN cord-028721-x6f26ahr 3670 10 of of IN cord-028721-x6f26ahr 3670 11 serum serum NN cord-028721-x6f26ahr 3670 12 from from IN cord-028721-x6f26ahr 3670 13 animals animal NNS cord-028721-x6f26ahr 3670 14 with with IN cord-028721-x6f26ahr 3670 15 orchitis orchitis NN cord-028721-x6f26ahr 3670 16 , , , cord-028721-x6f26ahr 3670 17 whereas whereas IN cord-028721-x6f26ahr 3670 18 interstitial interstitial JJ cord-028721-x6f26ahr 3670 19 orchitis orchitis NN cord-028721-x6f26ahr 3670 20 resembles resemble VBZ cord-028721-x6f26ahr 3670 21 orchitis orchitis NN cord-028721-x6f26ahr 3670 22 produced produce VBN cord-028721-x6f26ahr 3670 23 by by IN cord-028721-x6f26ahr 3670 24 the the DT cord-028721-x6f26ahr 3670 25 transfer transfer NN cord-028721-x6f26ahr 3670 26 of of IN cord-028721-x6f26ahr 3670 27 cells cell NNS cord-028721-x6f26ahr 3670 28 from from IN cord-028721-x6f26ahr 3670 29 immunized immunize VBN cord-028721-x6f26ahr 3670 30 animals animal NNS cord-028721-x6f26ahr 3670 31 . . . cord-028721-x6f26ahr 3671 1 The the DT cord-028721-x6f26ahr 3671 2 differential differential JJ cord-028721-x6f26ahr 3671 3 diagnosis diagnosis NN cord-028721-x6f26ahr 3671 4 of of IN cord-028721-x6f26ahr 3671 5 idiopathic idiopathic JJ cord-028721-x6f26ahr 3671 6 granulomatous granulomatous JJ cord-028721-x6f26ahr 3671 7 orchitis orchitis NN cord-028721-x6f26ahr 3671 8 is be VBZ cord-028721-x6f26ahr 3671 9 infectious infectious JJ cord-028721-x6f26ahr 3671 10 orchitis orchitis NN cord-028721-x6f26ahr 3671 11 caused cause VBN cord-028721-x6f26ahr 3671 12 by by IN cord-028721-x6f26ahr 3671 13 bacteria bacteria NNS cord-028721-x6f26ahr 3671 14 , , , cord-028721-x6f26ahr 3671 15 spirochetes spirochete NNS cord-028721-x6f26ahr 3671 16 , , , cord-028721-x6f26ahr 3671 17 fungi fungus NNS cord-028721-x6f26ahr 3671 18 , , , cord-028721-x6f26ahr 3671 19 or or CC cord-028721-x6f26ahr 3671 20 parasites parasite NNS cord-028721-x6f26ahr 3671 21 . . . cord-028721-x6f26ahr 3672 1 A a DT cord-028721-x6f26ahr 3672 2 useful useful JJ cord-028721-x6f26ahr 3672 3 clue clue NN cord-028721-x6f26ahr 3672 4 in in IN cord-028721-x6f26ahr 3672 5 the the DT cord-028721-x6f26ahr 3672 6 tubular tubular JJ cord-028721-x6f26ahr 3672 7 form form NN cord-028721-x6f26ahr 3672 8 is be VBZ cord-028721-x6f26ahr 3672 9 the the DT cord-028721-x6f26ahr 3672 10 presence presence NN cord-028721-x6f26ahr 3672 11 of of IN cord-028721-x6f26ahr 3672 12 giant giant JJ cord-028721-x6f26ahr 3672 13 cells cell NNS cord-028721-x6f26ahr 3672 14 within within IN cord-028721-x6f26ahr 3672 15 seminiferous seminiferous JJ cord-028721-x6f26ahr 3672 16 tubules tubule NNS cord-028721-x6f26ahr 3672 17 . . . cord-028721-x6f26ahr 3673 1 The the DT cord-028721-x6f26ahr 3673 2 occurrence occurrence NN cord-028721-x6f26ahr 3673 3 of of IN cord-028721-x6f26ahr 3673 4 focal focal JJ cord-028721-x6f26ahr 3673 5 lymphoid lymphoid JJ cord-028721-x6f26ahr 3673 6 cell cell NN cord-028721-x6f26ahr 3673 7 infi infi NNP cord-028721-x6f26ahr 3673 8 ltrates ltrates NNP cord-028721-x6f26ahr 3673 9 in in IN cord-028721-x6f26ahr 3673 10 the the DT cord-028721-x6f26ahr 3673 11 testicular testicular NNP cord-028721-x6f26ahr 3673 12 interstitium interstitium NN cord-028721-x6f26ahr 3673 13 is be VBZ cord-028721-x6f26ahr 3673 14 common common JJ cord-028721-x6f26ahr 3673 15 in in IN cord-028721-x6f26ahr 3673 16 infertile infertile JJ cord-028721-x6f26ahr 3673 17 patients patient NNS cord-028721-x6f26ahr 3673 18 , , , cord-028721-x6f26ahr 3673 19 1544 1544 CD cord-028721-x6f26ahr 3673 20 , , , cord-028721-x6f26ahr 3673 21 1545 1545 CD cord-028721-x6f26ahr 3673 22 patients patient NNS cord-028721-x6f26ahr 3673 23 who who WP cord-028721-x6f26ahr 3673 24 have have VBP cord-028721-x6f26ahr 3673 25 undergone undergo VBN cord-028721-x6f26ahr 3673 26 surgery surgery NN cord-028721-x6f26ahr 3673 27 for for IN cord-028721-x6f26ahr 3673 28 bilateral bilateral JJ cord-028721-x6f26ahr 3673 29 inguinal inguinal JJ cord-028721-x6f26ahr 3673 30 hernia hernia NN cord-028721-x6f26ahr 3673 31 , , , cord-028721-x6f26ahr 3673 32 1546 1546 CD cord-028721-x6f26ahr 3673 33 vasectomized vasectomize VBN cord-028721-x6f26ahr 3673 34 patients patient NNS cord-028721-x6f26ahr 3673 35 who who WP cord-028721-x6f26ahr 3673 36 developed develop VBD cord-028721-x6f26ahr 3673 37 post post JJ cord-028721-x6f26ahr 3673 38 - - JJ cord-028721-x6f26ahr 3673 39 infection infection JJ cord-028721-x6f26ahr 3673 40 obstruction obstruction NN cord-028721-x6f26ahr 3673 41 , , , cord-028721-x6f26ahr 3673 42 1547 1547 CD cord-028721-x6f26ahr 3673 43 after after IN cord-028721-x6f26ahr 3673 44 testicular testicular JJ cord-028721-x6f26ahr 3673 45 piercing piercing NN cord-028721-x6f26ahr 3673 46 , , , cord-028721-x6f26ahr 3673 47 1548 1548 CD cord-028721-x6f26ahr 3673 48 and and CC cord-028721-x6f26ahr 3673 49 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3673 50 . . . cord-028721-x6f26ahr 3674 1 1549 1549 CD cord-028721-x6f26ahr 3675 1 Infl Infl NNP cord-028721-x6f26ahr 3675 2 ammatory ammatory NNP cord-028721-x6f26ahr 3675 3 infi infi NNP cord-028721-x6f26ahr 3675 4 ltrates ltrates NNP cord-028721-x6f26ahr 3675 5 usually usually RB cord-028721-x6f26ahr 3675 6 involve involve VBP cord-028721-x6f26ahr 3675 7 the the DT cord-028721-x6f26ahr 3675 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 3675 9 tubules tubule NNS cord-028721-x6f26ahr 3675 10 , , , cord-028721-x6f26ahr 3675 11 and and CC cord-028721-x6f26ahr 3675 12 this this DT cord-028721-x6f26ahr 3675 13 suggests suggest VBZ cord-028721-x6f26ahr 3675 14 the the DT cord-028721-x6f26ahr 3675 15 disorder disorder NN cord-028721-x6f26ahr 3675 16 is be VBZ cord-028721-x6f26ahr 3675 17 due due JJ cord-028721-x6f26ahr 3675 18 to to IN cord-028721-x6f26ahr 3675 19 an an DT cord-028721-x6f26ahr 3675 20 immunologic immunologic JJ cord-028721-x6f26ahr 3675 21 response response NN cord-028721-x6f26ahr 3675 22 ( ( -LRB- cord-028721-x6f26ahr 3675 23 Fig Fig NNP cord-028721-x6f26ahr 3675 24 . . . cord-028721-x6f26ahr 3675 25 12 12 CD cord-028721-x6f26ahr 3675 26 - - SYM cord-028721-x6f26ahr 3675 27 163 163 CD cord-028721-x6f26ahr 3675 28 ) ) -RRB- cord-028721-x6f26ahr 3675 29 . . . cord-028721-x6f26ahr 3676 1 Pseudolymphoma Pseudolymphoma NNP cord-028721-x6f26ahr 3676 2 is be VBZ cord-028721-x6f26ahr 3676 3 a a DT cord-028721-x6f26ahr 3676 4 benign benign JJ cord-028721-x6f26ahr 3676 5 reactive reactive JJ cord-028721-x6f26ahr 3676 6 process process NN cord-028721-x6f26ahr 3676 7 with with IN cord-028721-x6f26ahr 3676 8 a a DT cord-028721-x6f26ahr 3676 9 lymphoid lymphoid JJ cord-028721-x6f26ahr 3676 10 cell cell NN cord-028721-x6f26ahr 3676 11 proliferation proliferation NN cord-028721-x6f26ahr 3676 12 so so RB cord-028721-x6f26ahr 3676 13 intense intense JJ cord-028721-x6f26ahr 3676 14 that that IN cord-028721-x6f26ahr 3676 15 it -PRON- PRP cord-028721-x6f26ahr 3676 16 may may MD cord-028721-x6f26ahr 3676 17 be be VB cord-028721-x6f26ahr 3676 18 mistaken mistake VBN cord-028721-x6f26ahr 3676 19 for for IN cord-028721-x6f26ahr 3676 20 lymphoma lymphoma NN cord-028721-x6f26ahr 3676 21 . . . cord-028721-x6f26ahr 3677 1 Testicular testicular JJ cord-028721-x6f26ahr 3677 2 pseudolymphoma pseudolymphoma NN cord-028721-x6f26ahr 3677 3 consists consist VBZ cord-028721-x6f26ahr 3677 4 of of IN cord-028721-x6f26ahr 3677 5 infl infl NNP cord-028721-x6f26ahr 3677 6 ammatory ammatory NNP cord-028721-x6f26ahr 3677 7 infi infi NNP cord-028721-x6f26ahr 3677 8 ltrates ltrates NNP cord-028721-x6f26ahr 3677 9 with with IN cord-028721-x6f26ahr 3677 10 numerous numerous JJ cord-028721-x6f26ahr 3677 11 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3677 12 and and CC cord-028721-x6f26ahr 3677 13 plasma plasma NN cord-028721-x6f26ahr 3677 14 cells cell NNS cord-028721-x6f26ahr 3677 15 that that WDT cord-028721-x6f26ahr 3677 16 partially partially RB cord-028721-x6f26ahr 3677 17 or or CC cord-028721-x6f26ahr 3677 18 totally totally RB cord-028721-x6f26ahr 3677 19 destroy destroy VB cord-028721-x6f26ahr 3677 20 testicular testicular JJ cord-028721-x6f26ahr 3677 21 parenchyma parenchyma NN cord-028721-x6f26ahr 3677 22 . . . cord-028721-x6f26ahr 3678 1 1550 1550 CD cord-028721-x6f26ahr 3678 2 , , , cord-028721-x6f26ahr 3678 3 1551 1551 CD cord-028721-x6f26ahr 3679 1 The the DT cord-028721-x6f26ahr 3679 2 differential differential JJ cord-028721-x6f26ahr 3679 3 diagnosis diagnosis NN cord-028721-x6f26ahr 3679 4 includes include VBZ cord-028721-x6f26ahr 3679 5 lymphoma lymphoma NN cord-028721-x6f26ahr 3679 6 , , , cord-028721-x6f26ahr 3679 7 various various JJ cord-028721-x6f26ahr 3679 8 forms form NNS cord-028721-x6f26ahr 3679 9 of of IN cord-028721-x6f26ahr 3679 10 orchitis orchitis NN cord-028721-x6f26ahr 3679 11 , , , cord-028721-x6f26ahr 3679 12 and and CC cord-028721-x6f26ahr 3679 13 seminoma seminoma NN cord-028721-x6f26ahr 3679 14 . . . cord-028721-x6f26ahr 3680 1 The the DT cord-028721-x6f26ahr 3680 2 diagnosis diagnosis NN cord-028721-x6f26ahr 3680 3 of of IN cord-028721-x6f26ahr 3680 4 lymphoma lymphoma NN cord-028721-x6f26ahr 3680 5 may may MD cord-028721-x6f26ahr 3680 6 be be VB cord-028721-x6f26ahr 3680 7 excluded exclude VBN cord-028721-x6f26ahr 3680 8 by by IN cord-028721-x6f26ahr 3680 9 the the DT cord-028721-x6f26ahr 3680 10 lack lack NN cord-028721-x6f26ahr 3680 11 of of IN cord-028721-x6f26ahr 3680 12 atypia atypia NN cord-028721-x6f26ahr 3680 13 and and CC cord-028721-x6f26ahr 3680 14 polyclonal polyclonal JJ cord-028721-x6f26ahr 3680 15 nature nature NN cord-028721-x6f26ahr 3680 16 of of IN cord-028721-x6f26ahr 3680 17 the the DT cord-028721-x6f26ahr 3680 18 infl infl NNP cord-028721-x6f26ahr 3680 19 ammation ammation NNP cord-028721-x6f26ahr 3680 20 . . . cord-028721-x6f26ahr 3681 1 Syphilitic syphilitic JJ cord-028721-x6f26ahr 3681 2 orchitis orchitis NN cord-028721-x6f26ahr 3681 3 also also RB cord-028721-x6f26ahr 3681 4 contains contain VBZ cord-028721-x6f26ahr 3681 5 a a DT cord-028721-x6f26ahr 3681 6 plasma plasma NN cord-028721-x6f26ahr 3681 7 cell cell NN cord-028721-x6f26ahr 3681 8 - - HYPH cord-028721-x6f26ahr 3681 9 rich rich JJ cord-028721-x6f26ahr 3681 10 infl infl NNP cord-028721-x6f26ahr 3681 11 ammatory ammatory NNP cord-028721-x6f26ahr 3681 12 infi infi NNP cord-028721-x6f26ahr 3681 13 ltrate ltrate NNP cord-028721-x6f26ahr 3681 14 , , , cord-028721-x6f26ahr 3681 15 but but CC cord-028721-x6f26ahr 3681 16 pseudolymphoma pseudolymphoma NNP cord-028721-x6f26ahr 3681 17 does do VBZ cord-028721-x6f26ahr 3681 18 not not RB cord-028721-x6f26ahr 3681 19 have have VB cord-028721-x6f26ahr 3681 20 other other JJ cord-028721-x6f26ahr 3681 21 characteristic characteristic JJ cord-028721-x6f26ahr 3681 22 features feature NNS cord-028721-x6f26ahr 3681 23 of of IN cord-028721-x6f26ahr 3681 24 syphilitic syphilitic JJ cord-028721-x6f26ahr 3681 25 orchitis orchiti NNS cord-028721-x6f26ahr 3681 26 , , , cord-028721-x6f26ahr 3681 27 such such JJ cord-028721-x6f26ahr 3681 28 as as IN cord-028721-x6f26ahr 3681 29 endarteritis endarteritis NN cord-028721-x6f26ahr 3681 30 obliterans obliteran NNS cord-028721-x6f26ahr 3681 31 ; ; : cord-028721-x6f26ahr 3681 32 spirochetes spirochete NNS cord-028721-x6f26ahr 3681 33 can can MD cord-028721-x6f26ahr 3681 34 not not RB cord-028721-x6f26ahr 3681 35 be be VB cord-028721-x6f26ahr 3681 36 demonstrated demonstrate VBN cord-028721-x6f26ahr 3681 37 by by IN cord-028721-x6f26ahr 3681 38 special special JJ cord-028721-x6f26ahr 3681 39 stains stain NNS cord-028721-x6f26ahr 3681 40 . . . cord-028721-x6f26ahr 3682 1 The the DT cord-028721-x6f26ahr 3682 2 lack lack NN cord-028721-x6f26ahr 3682 3 of of IN cord-028721-x6f26ahr 3682 4 granulomas granuloma NNS cord-028721-x6f26ahr 3682 5 or or CC cord-028721-x6f26ahr 3682 6 signifi signifi NNP cord-028721-x6f26ahr 3682 7 ca can MD cord-028721-x6f26ahr 3682 8 nt not RB cord-028721-x6f26ahr 3682 9 numbers number NNS cord-028721-x6f26ahr 3682 10 of of IN cord-028721-x6f26ahr 3682 11 macrophages macrophage NNS cord-028721-x6f26ahr 3682 12 , , , cord-028721-x6f26ahr 3682 13 together together RB cord-028721-x6f26ahr 3682 14 with with IN cord-028721-x6f26ahr 3682 15 the the DT cord-028721-x6f26ahr 3682 16 negative negative JJ cord-028721-x6f26ahr 3682 17 results result NNS cord-028721-x6f26ahr 3682 18 of of IN cord-028721-x6f26ahr 3682 19 specifi specifi NNP cord-028721-x6f26ahr 3682 20 c c NNP cord-028721-x6f26ahr 3682 21 histochemical histochemical NNP cord-028721-x6f26ahr 3682 22 stains stain NNS cord-028721-x6f26ahr 3682 23 , , , cord-028721-x6f26ahr 3682 24 also also RB cord-028721-x6f26ahr 3682 25 helps help VBZ cord-028721-x6f26ahr 3682 26 to to TO cord-028721-x6f26ahr 3682 27 exclude exclude VB cord-028721-x6f26ahr 3682 28 idiopathic idiopathic JJ cord-028721-x6f26ahr 3682 29 granulomatous granulomatous JJ cord-028721-x6f26ahr 3682 30 orchitis orchitis NN cord-028721-x6f26ahr 3682 31 , , , cord-028721-x6f26ahr 3682 32 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3682 33 , , , cord-028721-x6f26ahr 3682 34 leprosy leprosy NN cord-028721-x6f26ahr 3682 35 , , , cord-028721-x6f26ahr 3682 36 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 3682 37 , , , cord-028721-x6f26ahr 3682 38 and and CC cord-028721-x6f26ahr 3682 39 fungal fungal JJ cord-028721-x6f26ahr 3682 40 infection infection NN cord-028721-x6f26ahr 3682 41 . . . cord-028721-x6f26ahr 3683 1 Finally finally RB cord-028721-x6f26ahr 3683 2 , , , cord-028721-x6f26ahr 3683 3 although although IN cord-028721-x6f26ahr 3683 4 the the DT cord-028721-x6f26ahr 3683 5 presence presence NN cord-028721-x6f26ahr 3683 6 of of IN cord-028721-x6f26ahr 3683 7 a a DT cord-028721-x6f26ahr 3683 8 prominent prominent JJ cord-028721-x6f26ahr 3683 9 infl infl NNP cord-028721-x6f26ahr 3683 10 ammatory ammatory NNP cord-028721-x6f26ahr 3683 11 infi infi NNP cord-028721-x6f26ahr 3683 12 ltrate ltrate NNP cord-028721-x6f26ahr 3683 13 and and CC cord-028721-x6f26ahr 3683 14 , , , cord-028721-x6f26ahr 3683 15 in in IN cord-028721-x6f26ahr 3683 16 many many JJ cord-028721-x6f26ahr 3683 17 cases case NNS cord-028721-x6f26ahr 3683 18 , , , cord-028721-x6f26ahr 3683 19 numerous numerous JJ cord-028721-x6f26ahr 3683 20 lymphoid lymphoid JJ cord-028721-x6f26ahr 3683 21 follicles follicle NNS cord-028721-x6f26ahr 3683 22 , , , cord-028721-x6f26ahr 3683 23 may may MD cord-028721-x6f26ahr 3683 24 suggest suggest VB cord-028721-x6f26ahr 3683 25 the the DT cord-028721-x6f26ahr 3683 26 diagnosis diagnosis NN cord-028721-x6f26ahr 3683 27 of of IN cord-028721-x6f26ahr 3683 28 seminoma seminoma NN cord-028721-x6f26ahr 3683 29 , , , cord-028721-x6f26ahr 3683 30 the the DT cord-028721-x6f26ahr 3683 31 presence presence NN cord-028721-x6f26ahr 3683 32 of of IN cord-028721-x6f26ahr 3683 33 seminoma seminoma NN cord-028721-x6f26ahr 3683 34 cells cell NNS cord-028721-x6f26ahr 3683 35 should should MD cord-028721-x6f26ahr 3683 36 be be VB cord-028721-x6f26ahr 3683 37 easily easily RB cord-028721-x6f26ahr 3683 38 demonstrated demonstrate VBN cord-028721-x6f26ahr 3683 39 with with IN cord-028721-x6f26ahr 3683 40 Best Best NNP cord-028721-x6f26ahr 3683 41 's 's POS cord-028721-x6f26ahr 3683 42 carmine carmine JJ cord-028721-x6f26ahr 3683 43 stain stain NN cord-028721-x6f26ahr 3683 44 , , , cord-028721-x6f26ahr 3683 45 periodic periodic JJ cord-028721-x6f26ahr 3683 46 acid acid NN cord-028721-x6f26ahr 3683 47 - - HYPH cord-028721-x6f26ahr 3683 48 Schiff Schiff NNP cord-028721-x6f26ahr 3683 49 , , , cord-028721-x6f26ahr 3683 50 or or CC cord-028721-x6f26ahr 3683 51 placenta placenta NN cord-028721-x6f26ahr 3683 52 - - HYPH cord-028721-x6f26ahr 3683 53 like like JJ cord-028721-x6f26ahr 3683 54 alkaline alkaline JJ cord-028721-x6f26ahr 3683 55 phosphatase phosphatase NN cord-028721-x6f26ahr 3683 56 . . . cord-028721-x6f26ahr 3684 1 The the DT cord-028721-x6f26ahr 3684 2 term term NN cord-028721-x6f26ahr 3684 3 plasma plasma NN cord-028721-x6f26ahr 3684 4 cell cell NN cord-028721-x6f26ahr 3684 5 granuloma granuloma NN cord-028721-x6f26ahr 3684 6 1152 1152 CD cord-028721-x6f26ahr 3684 7 refers refer VBZ cord-028721-x6f26ahr 3684 8 to to IN cord-028721-x6f26ahr 3684 9 a a DT cord-028721-x6f26ahr 3684 10 reactive reactive JJ cord-028721-x6f26ahr 3684 11 process process NN cord-028721-x6f26ahr 3684 12 characterized characterize VBN cord-028721-x6f26ahr 3684 13 by by IN cord-028721-x6f26ahr 3684 14 the the DT cord-028721-x6f26ahr 3684 15 presence presence NN cord-028721-x6f26ahr 3684 16 of of IN cord-028721-x6f26ahr 3684 17 polyclonal polyclonal JJ cord-028721-x6f26ahr 3684 18 adult adult NN cord-028721-x6f26ahr 3684 19 plasma plasma NN cord-028721-x6f26ahr 3684 20 cells cell NNS cord-028721-x6f26ahr 3684 21 that that WDT cord-028721-x6f26ahr 3684 22 are be VBP cord-028721-x6f26ahr 3684 23 absent absent JJ cord-028721-x6f26ahr 3684 24 in in IN cord-028721-x6f26ahr 3684 25 testicular testicular JJ cord-028721-x6f26ahr 3684 26 plasmacytoma plasmacytoma NNP cord-028721-x6f26ahr 3684 27 . . . cord-028721-x6f26ahr 3685 1 1553 1553 CD cord-028721-x6f26ahr 3685 2 Sinus Sinus NNP cord-028721-x6f26ahr 3685 3 histiocytosis histiocytosis NN cord-028721-x6f26ahr 3685 4 with with IN cord-028721-x6f26ahr 3685 5 massive massive JJ cord-028721-x6f26ahr 3685 6 lymphadenopathy lymphadenopathy NN cord-028721-x6f26ahr 3685 7 ( ( -LRB- cord-028721-x6f26ahr 3685 8 Rosai Rosai NNP cord-028721-x6f26ahr 3685 9 - - HYPH cord-028721-x6f26ahr 3685 10 Dorfman Dorfman NNP cord-028721-x6f26ahr 3685 11 disease disease NN cord-028721-x6f26ahr 3685 12 ) ) -RRB- cord-028721-x6f26ahr 3685 13 is be VBZ cord-028721-x6f26ahr 3685 14 a a DT cord-028721-x6f26ahr 3685 15 benign benign JJ cord-028721-x6f26ahr 3685 16 proliferation proliferation NN cord-028721-x6f26ahr 3685 17 of of IN cord-028721-x6f26ahr 3685 18 macrophages macrophage NNS cord-028721-x6f26ahr 3685 19 that that WDT cord-028721-x6f26ahr 3685 20 uniquely uniquely RB cord-028721-x6f26ahr 3685 21 contain contain VBP cord-028721-x6f26ahr 3685 22 numerous numerous JJ cord-028721-x6f26ahr 3685 23 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3685 24 in in IN cord-028721-x6f26ahr 3685 25 their -PRON- PRP$ cord-028721-x6f26ahr 3685 26 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3685 27 . . . cord-028721-x6f26ahr 3686 1 The the DT cord-028721-x6f26ahr 3686 2 disease disease NN cord-028721-x6f26ahr 3686 3 was be VBD cord-028721-x6f26ahr 3686 4 reported report VBN cord-028721-x6f26ahr 3686 5 in in IN cord-028721-x6f26ahr 3686 6 a a DT cord-028721-x6f26ahr 3686 7 kidney kidney NN cord-028721-x6f26ahr 3686 8 and and CC cord-028721-x6f26ahr 3686 9 testis testis NN cord-028721-x6f26ahr 3686 10 of of IN cord-028721-x6f26ahr 3686 11 a a DT cord-028721-x6f26ahr 3686 12 patient patient NN cord-028721-x6f26ahr 3686 13 in in IN cord-028721-x6f26ahr 3686 14 remission remission NN cord-028721-x6f26ahr 3686 15 from from IN cord-028721-x6f26ahr 3686 16 malignant malignant JJ cord-028721-x6f26ahr 3686 17 lymphoma lymphoma NN cord-028721-x6f26ahr 3686 18 in in IN cord-028721-x6f26ahr 3686 19 association association NN cord-028721-x6f26ahr 3686 20 with with IN cord-028721-x6f26ahr 3686 21 monoclonal monoclonal NNP cord-028721-x6f26ahr 3686 22 IgA IgA NNP cord-028721-x6f26ahr 3686 23 gammopathy gammopathy NNP cord-028721-x6f26ahr 3686 24 , , , cord-028721-x6f26ahr 3686 25 1554 1554 CD cord-028721-x6f26ahr 3686 26 and and CC cord-028721-x6f26ahr 3686 27 in in IN cord-028721-x6f26ahr 3686 28 a a DT cord-028721-x6f26ahr 3686 29 second second JJ cord-028721-x6f26ahr 3686 30 patient patient NN cord-028721-x6f26ahr 3686 31 with with IN cord-028721-x6f26ahr 3686 32 diabetes diabetes NN cord-028721-x6f26ahr 3686 33 mellitus mellitus NN cord-028721-x6f26ahr 3686 34 who who WP cord-028721-x6f26ahr 3686 35 had have VBD cord-028721-x6f26ahr 3686 36 been be VBN cord-028721-x6f26ahr 3686 37 previously previously RB cord-028721-x6f26ahr 3686 38 treated treat VBN cord-028721-x6f26ahr 3686 39 for for IN cord-028721-x6f26ahr 3686 40 pulmonary pulmonary JJ cord-028721-x6f26ahr 3686 41 tuberculosis tuberculosis NN cord-028721-x6f26ahr 3686 42 . . . cord-028721-x6f26ahr 3687 1 1555 1555 CD cord-028721-x6f26ahr 3687 2 Increased increase VBN cord-028721-x6f26ahr 3687 3 numbers number NNS cord-028721-x6f26ahr 3687 4 of of IN cord-028721-x6f26ahr 3687 5 interstitial interstitial JJ cord-028721-x6f26ahr 3687 6 macrophages macrophage NNS cord-028721-x6f26ahr 3687 7 may may MD cord-028721-x6f26ahr 3687 8 also also RB cord-028721-x6f26ahr 3687 9 be be VB cord-028721-x6f26ahr 3687 10 observed observe VBN cord-028721-x6f26ahr 3687 11 in in IN cord-028721-x6f26ahr 3687 12 more more JJR cord-028721-x6f26ahr 3687 13 than than IN cord-028721-x6f26ahr 3687 14 two two CD cord-028721-x6f26ahr 3687 15 - - HYPH cord-028721-x6f26ahr 3687 16 thirds third NNS cord-028721-x6f26ahr 3687 17 of of IN cord-028721-x6f26ahr 3687 18 autopsies autopsy NNS cord-028721-x6f26ahr 3687 19 from from IN cord-028721-x6f26ahr 3687 20 adult adult NN cord-028721-x6f26ahr 3687 21 patients patient NNS cord-028721-x6f26ahr 3687 22 , , , cord-028721-x6f26ahr 3687 23 but but CC cord-028721-x6f26ahr 3687 24 the the DT cord-028721-x6f26ahr 3687 25 cause cause NN cord-028721-x6f26ahr 3687 26 is be VBZ cord-028721-x6f26ahr 3687 27 unknown unknown JJ cord-028721-x6f26ahr 3687 28 . . . cord-028721-x6f26ahr 3688 1 One one CD cord-028721-x6f26ahr 3688 2 condition condition NN cord-028721-x6f26ahr 3688 3 associated associate VBN cord-028721-x6f26ahr 3688 4 with with IN cord-028721-x6f26ahr 3688 5 this this DT cord-028721-x6f26ahr 3688 6 disorder disorder NN cord-028721-x6f26ahr 3688 7 is be VBZ cord-028721-x6f26ahr 3688 8 treatment treatment NN cord-028721-x6f26ahr 3688 9 with with IN cord-028721-x6f26ahr 3688 10 hydroxyethylstarch hydroxyethylstarch NN cord-028721-x6f26ahr 3688 11 plasma plasma NN cord-028721-x6f26ahr 3688 12 expander expander NN cord-028721-x6f26ahr 3688 13 . . . cord-028721-x6f26ahr 3689 1 In in IN cord-028721-x6f26ahr 3689 2 this this DT cord-028721-x6f26ahr 3689 3 lesion lesion NN cord-028721-x6f26ahr 3689 4 , , , cord-028721-x6f26ahr 3689 5 the the DT cord-028721-x6f26ahr 3689 6 interstitial interstitial JJ cord-028721-x6f26ahr 3689 7 macrophages macrophage NNS cord-028721-x6f26ahr 3689 8 stand stand VBP cord-028721-x6f26ahr 3689 9 out out RP cord-028721-x6f26ahr 3689 10 by by IN cord-028721-x6f26ahr 3689 11 virtue virtue NN cord-028721-x6f26ahr 3689 12 of of IN cord-028721-x6f26ahr 3689 13 their -PRON- PRP$ cord-028721-x6f26ahr 3689 14 large large JJ cord-028721-x6f26ahr 3689 15 size size NN cord-028721-x6f26ahr 3689 16 and and CC cord-028721-x6f26ahr 3689 17 multivacuolated multivacuolated JJ cord-028721-x6f26ahr 3689 18 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3689 19 , , , cord-028721-x6f26ahr 3689 20 suggesting suggest VBG cord-028721-x6f26ahr 3689 21 thesaurosis thesaurosis NNP cord-028721-x6f26ahr 3689 22 . . . cord-028721-x6f26ahr 3690 1 There there EX cord-028721-x6f26ahr 3690 2 is be VBZ cord-028721-x6f26ahr 3690 3 no no DT cord-028721-x6f26ahr 3690 4 evidence evidence NN cord-028721-x6f26ahr 3690 5 of of IN cord-028721-x6f26ahr 3690 6 mucin mucin NN cord-028721-x6f26ahr 3690 7 glycoproteins glycoprotein NNS cord-028721-x6f26ahr 3690 8 , , , cord-028721-x6f26ahr 3690 9 proteoglycans proteoglycan NNS cord-028721-x6f26ahr 3690 10 , , , cord-028721-x6f26ahr 3690 11 starch starch NN cord-028721-x6f26ahr 3690 12 , , , cord-028721-x6f26ahr 3690 13 lipids lipid NNS cord-028721-x6f26ahr 3690 14 , , , cord-028721-x6f26ahr 3690 15 glycogen glycogen NN cord-028721-x6f26ahr 3690 16 , , , cord-028721-x6f26ahr 3690 17 or or CC cord-028721-x6f26ahr 3690 18 foreign foreign JJ cord-028721-x6f26ahr 3690 19 body body NN cord-028721-x6f26ahr 3690 20 material material NN cord-028721-x6f26ahr 3690 21 . . . cord-028721-x6f26ahr 3691 1 Most Most JJS cord-028721-x6f26ahr 3691 2 patients patient NNS cord-028721-x6f26ahr 3691 3 have have VBP cord-028721-x6f26ahr 3691 4 no no DT cord-028721-x6f26ahr 3691 5 clinical clinical JJ cord-028721-x6f26ahr 3691 6 symptoms symptom NNS cord-028721-x6f26ahr 3691 7 other other JJ cord-028721-x6f26ahr 3691 8 than than IN cord-028721-x6f26ahr 3691 9 pruritus pruritus NN cord-028721-x6f26ahr 3691 10 and and CC cord-028721-x6f26ahr 3691 11 persistent persistent JJ cord-028721-x6f26ahr 3691 12 erythrema erythrema NN cord-028721-x6f26ahr 3691 13 . . . cord-028721-x6f26ahr 3692 1 1556 1556 CD cord-028721-x6f26ahr 3692 2 Epididymitis Epididymitis NNP cord-028721-x6f26ahr 3692 3 nodosa nodosa RB cord-028721-x6f26ahr 3692 4 is be VBZ cord-028721-x6f26ahr 3692 5 a a DT cord-028721-x6f26ahr 3692 6 proliferation proliferation NN cord-028721-x6f26ahr 3692 7 of of IN cord-028721-x6f26ahr 3692 8 small small JJ cord-028721-x6f26ahr 3692 9 irregular irregular JJ cord-028721-x6f26ahr 3692 10 ducts duct NNS cord-028721-x6f26ahr 3692 11 whose whose WP$ cord-028721-x6f26ahr 3692 12 epithelium epithelium NN cord-028721-x6f26ahr 3692 13 lacks lack VBZ cord-028721-x6f26ahr 3692 14 the the DT cord-028721-x6f26ahr 3692 15 characteristic characteristic JJ cord-028721-x6f26ahr 3692 16 features feature NNS cord-028721-x6f26ahr 3692 17 of of IN cord-028721-x6f26ahr 3692 18 the the DT cord-028721-x6f26ahr 3692 19 epididymal epididymal JJ cord-028721-x6f26ahr 3692 20 epithelium epithelium NN cord-028721-x6f26ahr 3692 21 . . . cord-028721-x6f26ahr 3693 1 The the DT cord-028721-x6f26ahr 3693 2 disorder disorder NN cord-028721-x6f26ahr 3693 3 is be VBZ cord-028721-x6f26ahr 3693 4 associated associate VBN cord-028721-x6f26ahr 3693 5 with with IN cord-028721-x6f26ahr 3693 6 infl infl NN cord-028721-x6f26ahr 3693 7 ammation ammation NN cord-028721-x6f26ahr 3693 8 and and CC cord-028721-x6f26ahr 3693 9 fi fi NNP cord-028721-x6f26ahr 3693 10 brosis brosis NNP cord-028721-x6f26ahr 3693 11 , , , cord-028721-x6f26ahr 3693 12 similar similar JJ cord-028721-x6f26ahr 3693 13 to to IN cord-028721-x6f26ahr 3693 14 vasitis vasitis NNP cord-028721-x6f26ahr 3693 15 nodosa nodosa NNP cord-028721-x6f26ahr 3693 16 . . . cord-028721-x6f26ahr 3694 1 1557 1557 CD cord-028721-x6f26ahr 3695 1 In in IN cord-028721-x6f26ahr 3695 2 several several JJ cord-028721-x6f26ahr 3695 3 tissues tissue NNS cord-028721-x6f26ahr 3695 4 , , , cord-028721-x6f26ahr 3695 5 including include VBG cord-028721-x6f26ahr 3695 6 the the DT cord-028721-x6f26ahr 3695 7 testis testis NN cord-028721-x6f26ahr 3695 8 , , , cord-028721-x6f26ahr 3695 9 amiodarone amiodarone NN cord-028721-x6f26ahr 3695 10 is be VBZ cord-028721-x6f26ahr 3695 11 concentrated concentrate VBN cord-028721-x6f26ahr 3695 12 up up RP cord-028721-x6f26ahr 3695 13 to to TO cord-028721-x6f26ahr 3695 14 300 300 CD cord-028721-x6f26ahr 3695 15 times time NNS cord-028721-x6f26ahr 3695 16 its -PRON- PRP$ cord-028721-x6f26ahr 3695 17 plasma plasma NN cord-028721-x6f26ahr 3695 18 level level NN cord-028721-x6f26ahr 3695 19 , , , cord-028721-x6f26ahr 3695 20 1558 1558 CD cord-028721-x6f26ahr 3695 21 causing cause VBG cord-028721-x6f26ahr 3695 22 testicular testicular JJ cord-028721-x6f26ahr 3695 23 atrophy atrophy NN cord-028721-x6f26ahr 3695 24 and and CC cord-028721-x6f26ahr 3695 25 increased increase VBN cord-028721-x6f26ahr 3695 26 serum serum NN cord-028721-x6f26ahr 3695 27 levels level NNS cord-028721-x6f26ahr 3695 28 of of IN cord-028721-x6f26ahr 3695 29 FSH fsh NN cord-028721-x6f26ahr 3695 30 and and CC cord-028721-x6f26ahr 3695 31 LH lh NN cord-028721-x6f26ahr 3695 32 in in IN cord-028721-x6f26ahr 3695 33 some some DT cord-028721-x6f26ahr 3695 34 patients patient NNS cord-028721-x6f26ahr 3695 35 . . . cord-028721-x6f26ahr 3696 1 1559 1559 CD cord-028721-x6f26ahr 3697 1 The the DT cord-028721-x6f26ahr 3697 2 incidence incidence NN cord-028721-x6f26ahr 3697 3 of of IN cord-028721-x6f26ahr 3697 4 epididymitis epididymitis NN cord-028721-x6f26ahr 3697 5 during during IN cord-028721-x6f26ahr 3697 6 amiodarone amiodarone NN cord-028721-x6f26ahr 3697 7 therapy therapy NN cord-028721-x6f26ahr 3697 8 varies vary VBZ cord-028721-x6f26ahr 3697 9 from from IN cord-028721-x6f26ahr 3697 10 3 3 CD cord-028721-x6f26ahr 3697 11 % % NN cord-028721-x6f26ahr 3697 12 to to IN cord-028721-x6f26ahr 3697 13 11 11 CD cord-028721-x6f26ahr 3697 14 % % NN cord-028721-x6f26ahr 3697 15 , , , cord-028721-x6f26ahr 3697 16 1560 1560 CD cord-028721-x6f26ahr 3697 17 , , , cord-028721-x6f26ahr 3697 18 1561 1561 CD cord-028721-x6f26ahr 3697 19 and and CC cord-028721-x6f26ahr 3697 20 more more JJR cord-028721-x6f26ahr 3697 21 than than IN cord-028721-x6f26ahr 3697 22 35 35 CD cord-028721-x6f26ahr 3697 23 cases case NNS cord-028721-x6f26ahr 3697 24 ( ( -LRB- cord-028721-x6f26ahr 3697 25 in in IN cord-028721-x6f26ahr 3697 26 several several JJ cord-028721-x6f26ahr 3697 27 cases case NNS cord-028721-x6f26ahr 3697 28 involvement involvement NN cord-028721-x6f26ahr 3697 29 was be VBD cord-028721-x6f26ahr 3697 30 bilateral bilateral JJ cord-028721-x6f26ahr 3697 31 ) ) -RRB- cord-028721-x6f26ahr 3697 32 have have VBP cord-028721-x6f26ahr 3697 33 been be VBN cord-028721-x6f26ahr 3697 34 reported report VBN cord-028721-x6f26ahr 3697 35 , , , cord-028721-x6f26ahr 3697 36 although although IN cord-028721-x6f26ahr 3697 37 there there EX cord-028721-x6f26ahr 3697 38 are be VBP cord-028721-x6f26ahr 3697 39 probably probably RB cord-028721-x6f26ahr 3697 40 many many JJ cord-028721-x6f26ahr 3697 41 others other NNS cord-028721-x6f26ahr 3697 42 . . . cord-028721-x6f26ahr 3698 1 1562 1562 CD cord-028721-x6f26ahr 3698 2 , , , cord-028721-x6f26ahr 3698 3 1563 1563 CD cord-028721-x6f26ahr 3699 1 The the DT cord-028721-x6f26ahr 3699 2 disorder disorder NN cord-028721-x6f26ahr 3699 3 may may MD cord-028721-x6f26ahr 3699 4 occur occur VB cord-028721-x6f26ahr 3699 5 at at IN cord-028721-x6f26ahr 3699 6 any any DT cord-028721-x6f26ahr 3699 7 age age NN cord-028721-x6f26ahr 3699 8 . . . cord-028721-x6f26ahr 3700 1 1564 1564 CD cord-028721-x6f26ahr 3701 1 When when WRB cord-028721-x6f26ahr 3701 2 amiodarone amiodarone NN cord-028721-x6f26ahr 3701 3 dosage dosage NN cord-028721-x6f26ahr 3701 4 is be VBZ cord-028721-x6f26ahr 3701 5 reduced reduce VBN cord-028721-x6f26ahr 3701 6 to to IN cord-028721-x6f26ahr 3701 7 300 300 CD cord-028721-x6f26ahr 3701 8 mg mg NNP cord-028721-x6f26ahr 3701 9 / / SYM cord-028721-x6f26ahr 3701 10 day day NN cord-028721-x6f26ahr 3701 11 the the DT cord-028721-x6f26ahr 3701 12 epididymitis epididymitis NN cord-028721-x6f26ahr 3701 13 heals heal VBZ cord-028721-x6f26ahr 3701 14 within within IN cord-028721-x6f26ahr 3701 15 a a DT cord-028721-x6f26ahr 3701 16 few few JJ cord-028721-x6f26ahr 3701 17 weeks week NNS cord-028721-x6f26ahr 3701 18 . . . cord-028721-x6f26ahr 3702 1 1565 1565 CD cord-028721-x6f26ahr 3703 1 Autopsy autopsy JJ cord-028721-x6f26ahr 3703 2 studies study NNS cord-028721-x6f26ahr 3703 3 show show VBP cord-028721-x6f26ahr 3703 4 focal focal JJ cord-028721-x6f26ahr 3703 5 areas area NNS cord-028721-x6f26ahr 3703 6 of of IN cord-028721-x6f26ahr 3703 7 fi fi NN cord-028721-x6f26ahr 3703 8 brosis brosis NN cord-028721-x6f26ahr 3703 9 and and CC cord-028721-x6f26ahr 3703 10 lymphoid lymphoid JJ cord-028721-x6f26ahr 3703 11 cell cell NN cord-028721-x6f26ahr 3703 12 infi infi NNP cord-028721-x6f26ahr 3703 13 ltrates ltrates NNP cord-028721-x6f26ahr 3703 14 not not RB cord-028721-x6f26ahr 3703 15 related relate VBN cord-028721-x6f26ahr 3703 16 to to IN cord-028721-x6f26ahr 3703 17 infection infection NN cord-028721-x6f26ahr 3703 18 . . . cord-028721-x6f26ahr 3704 1 Recognition recognition NN cord-028721-x6f26ahr 3704 2 is be VBZ cord-028721-x6f26ahr 3704 3 important important JJ cord-028721-x6f26ahr 3704 4 to to TO cord-028721-x6f26ahr 3704 5 avoid avoid VB cord-028721-x6f26ahr 3704 6 unnecessary unnecessary JJ cord-028721-x6f26ahr 3704 7 antibiotics antibiotic NNS cord-028721-x6f26ahr 3704 8 or or CC cord-028721-x6f26ahr 3704 9 aggressive aggressive JJ cord-028721-x6f26ahr 3704 10 surgery surgery NN cord-028721-x6f26ahr 3704 11 . . . cord-028721-x6f26ahr 3705 1 This this DT cord-028721-x6f26ahr 3705 2 term term NN cord-028721-x6f26ahr 3705 3 describes describe VBZ cord-028721-x6f26ahr 3705 4 a a DT cord-028721-x6f26ahr 3705 5 lesion lesion NN cord-028721-x6f26ahr 3705 6 located locate VBN cord-028721-x6f26ahr 3705 7 in in IN cord-028721-x6f26ahr 3705 8 the the DT cord-028721-x6f26ahr 3705 9 epididymal epididymal JJ cord-028721-x6f26ahr 3705 10 head head NN cord-028721-x6f26ahr 3705 11 characterized characterize VBN cord-028721-x6f26ahr 3705 12 by by IN cord-028721-x6f26ahr 3705 13 non non JJ cord-028721-x6f26ahr 3705 14 - - JJ cord-028721-x6f26ahr 3705 15 infectious infectious JJ cord-028721-x6f26ahr 3705 16 necrosis necrosis NN cord-028721-x6f26ahr 3705 17 with with IN cord-028721-x6f26ahr 3705 18 polypoid polypoid JJ cord-028721-x6f26ahr 3705 19 masses masse NNS cord-028721-x6f26ahr 3705 20 of of IN cord-028721-x6f26ahr 3705 21 infl infl NNP cord-028721-x6f26ahr 3705 22 amed amed NNP cord-028721-x6f26ahr 3705 23 granulation granulation NN cord-028721-x6f26ahr 3705 24 tissue tissue NN cord-028721-x6f26ahr 3705 25 in in IN cord-028721-x6f26ahr 3705 26 peripheral peripheral JJ cord-028721-x6f26ahr 3705 27 ductal ductal JJ cord-028721-x6f26ahr 3705 28 structures structure NNS cord-028721-x6f26ahr 3705 29 . . . cord-028721-x6f26ahr 3706 1 Granulomas granuloma NNS cord-028721-x6f26ahr 3706 2 containing contain VBG cord-028721-x6f26ahr 3706 3 multinucleated multinucleate VBN cord-028721-x6f26ahr 3706 4 giant giant JJ cord-028721-x6f26ahr 3706 5 cells cell NNS cord-028721-x6f26ahr 3706 6 present present JJ cord-028721-x6f26ahr 3706 7 within within IN cord-028721-x6f26ahr 3706 8 efferent efferent JJ cord-028721-x6f26ahr 3706 9 ductuli ductuli NNS cord-028721-x6f26ahr 3706 10 or or CC cord-028721-x6f26ahr 3706 11 form form VB cord-028721-x6f26ahr 3706 12 sperm sperm NN cord-028721-x6f26ahr 3706 13 microgranulomas microgranulomas NN cord-028721-x6f26ahr 3706 14 with with IN cord-028721-x6f26ahr 3706 15 ductal ductal JJ cord-028721-x6f26ahr 3706 16 neoformation neoformation NN cord-028721-x6f26ahr 3706 17 similar similar JJ cord-028721-x6f26ahr 3706 18 to to IN cord-028721-x6f26ahr 3706 19 that that DT cord-028721-x6f26ahr 3706 20 of of IN cord-028721-x6f26ahr 3706 21 epididymitis epididymitis NN cord-028721-x6f26ahr 3706 22 nodosa nodosa RB cord-028721-x6f26ahr 3706 23 . . . cord-028721-x6f26ahr 3707 1 The the DT cord-028721-x6f26ahr 3707 2 cause cause NN cord-028721-x6f26ahr 3707 3 is be VBZ cord-028721-x6f26ahr 3707 4 unknown unknown JJ cord-028721-x6f26ahr 3707 5 , , , cord-028721-x6f26ahr 3707 6 but but CC cord-028721-x6f26ahr 3707 7 may may MD cord-028721-x6f26ahr 3707 8 result result VB cord-028721-x6f26ahr 3707 9 from from IN cord-028721-x6f26ahr 3707 10 ischemia ischemia NN cord-028721-x6f26ahr 3707 11 . . . cord-028721-x6f26ahr 3708 1 1566 1566 CD cord-028721-x6f26ahr 3709 1 The the DT cord-028721-x6f26ahr 3709 2 terms term NNS cord-028721-x6f26ahr 3709 3 ' ' POS cord-028721-x6f26ahr 3709 4 testicular testicular NN cord-028721-x6f26ahr 3709 5 calculus calculus NN cord-028721-x6f26ahr 3709 6 ' ' '' cord-028721-x6f26ahr 3709 7 and and CC cord-028721-x6f26ahr 3709 8 ' ' `` cord-028721-x6f26ahr 3709 9 stone stone NN cord-028721-x6f26ahr 3709 10 in in IN cord-028721-x6f26ahr 3709 11 the the DT cord-028721-x6f26ahr 3709 12 testis testis NN cord-028721-x6f26ahr 3709 13 ' ' '' cord-028721-x6f26ahr 3709 14 have have VBP cord-028721-x6f26ahr 3709 15 been be VBN cord-028721-x6f26ahr 3709 16 used use VBN cord-028721-x6f26ahr 3709 17 to to TO cord-028721-x6f26ahr 3709 18 describe describe VB cord-028721-x6f26ahr 3709 19 a a DT cord-028721-x6f26ahr 3709 20 lesion lesion NN cord-028721-x6f26ahr 3709 21 characterized characterize VBN cord-028721-x6f26ahr 3709 22 by by IN cord-028721-x6f26ahr 3709 23 the the DT cord-028721-x6f26ahr 3709 24 presence presence NN cord-028721-x6f26ahr 3709 25 of of IN cord-028721-x6f26ahr 3709 26 nodular nodular JJ cord-028721-x6f26ahr 3709 27 testicular testicular NNP cord-028721-x6f26ahr 3709 28 calcifi calcifi NNP cord-028721-x6f26ahr 3709 29 cation cation NNP cord-028721-x6f26ahr 3709 30 that that WDT cord-028721-x6f26ahr 3709 31 is be VBZ cord-028721-x6f26ahr 3709 32 not not RB cord-028721-x6f26ahr 3709 33 related relate VBN cord-028721-x6f26ahr 3709 34 to to IN cord-028721-x6f26ahr 3709 35 ischemia ischemia NN cord-028721-x6f26ahr 3709 36 , , , cord-028721-x6f26ahr 3709 37 orchitis orchitis NN cord-028721-x6f26ahr 3709 38 , , , cord-028721-x6f26ahr 3709 39 vasculitis vasculitis NN cord-028721-x6f26ahr 3709 40 , , , cord-028721-x6f26ahr 3709 41 hematoma hematoma NN cord-028721-x6f26ahr 3709 42 , , , cord-028721-x6f26ahr 3709 43 or or CC cord-028721-x6f26ahr 3709 44 tumor tumor NN cord-028721-x6f26ahr 3709 45 . . . cord-028721-x6f26ahr 3710 1 1567 1567 CD cord-028721-x6f26ahr 3710 2 , , , cord-028721-x6f26ahr 3710 3 1568 1568 CD cord-028721-x6f26ahr 3710 4 _SP cord-028721-x6f26ahr 3711 1 The the DT cord-028721-x6f26ahr 3711 2 testicular testicular JJ cord-028721-x6f26ahr 3711 3 arteries artery NNS cord-028721-x6f26ahr 3711 4 may may MD cord-028721-x6f26ahr 3711 5 be be VB cord-028721-x6f26ahr 3711 6 affected affect VBN cord-028721-x6f26ahr 3711 7 by by IN cord-028721-x6f26ahr 3711 8 systemic systemic JJ cord-028721-x6f26ahr 3711 9 disorders disorder NNS cord-028721-x6f26ahr 3711 10 such such JJ cord-028721-x6f26ahr 3711 11 as as IN cord-028721-x6f26ahr 3711 12 Schönlein Schönlein NNP cord-028721-x6f26ahr 3711 13 - - HYPH cord-028721-x6f26ahr 3711 14 Henoch Henoch NNP cord-028721-x6f26ahr 3711 15 purpura purpura NN cord-028721-x6f26ahr 3711 16 , , , cord-028721-x6f26ahr 3711 17 1569 1569 CD cord-028721-x6f26ahr 3711 18 Wegener Wegener NNP cord-028721-x6f26ahr 3711 19 's 's POS cord-028721-x6f26ahr 3711 20 disease disease NN cord-028721-x6f26ahr 3711 21 , , , cord-028721-x6f26ahr 3711 22 1570 1570 CD cord-028721-x6f26ahr 3711 23 , , , cord-028721-x6f26ahr 3711 24 1571 1571 CD cord-028721-x6f26ahr 3711 25 Kogan Kogan NNP cord-028721-x6f26ahr 3711 26 's 's POS cord-028721-x6f26ahr 3711 27 disease disease NN cord-028721-x6f26ahr 3711 28 , , , cord-028721-x6f26ahr 3711 29 1572 1572 CD cord-028721-x6f26ahr 3711 30 Behçet Behçet NNP cord-028721-x6f26ahr 3711 31 's 's POS cord-028721-x6f26ahr 3711 32 disease disease NN cord-028721-x6f26ahr 3711 33 , , , cord-028721-x6f26ahr 3711 34 1573 1573 CD cord-028721-x6f26ahr 3711 35 relapsing relapse VBG cord-028721-x6f26ahr 3711 36 polychondritis polychondritis NN cord-028721-x6f26ahr 3711 37 , , , cord-028721-x6f26ahr 3711 38 rheumatoid rheumatoid JJ cord-028721-x6f26ahr 3711 39 arthritis arthritis NN cord-028721-x6f26ahr 3711 40 , , , cord-028721-x6f26ahr 3711 41 and and CC cord-028721-x6f26ahr 3711 42 dermatomyositis dermatomyositis NNP cord-028721-x6f26ahr 3711 43 , , , cord-028721-x6f26ahr 3711 44 but but CC cord-028721-x6f26ahr 3711 45 the the DT cord-028721-x6f26ahr 3711 46 most most RBS cord-028721-x6f26ahr 3711 47 frequent frequent JJ cord-028721-x6f26ahr 3711 48 involvement involvement NN cord-028721-x6f26ahr 3711 49 is be VBZ cord-028721-x6f26ahr 3711 50 with with IN cord-028721-x6f26ahr 3711 51 polyarteritis polyarteritis NNP cord-028721-x6f26ahr 3711 52 nodosa nodosa RB cord-028721-x6f26ahr 3711 53 . . . cord-028721-x6f26ahr 3712 1 1574 1574 CD cord-028721-x6f26ahr 3712 2 Approximately approximately RB cord-028721-x6f26ahr 3712 3 80 80 CD cord-028721-x6f26ahr 3712 4 % % NN cord-028721-x6f26ahr 3712 5 of of IN cord-028721-x6f26ahr 3712 6 patients patient NNS cord-028721-x6f26ahr 3712 7 with with IN cord-028721-x6f26ahr 3712 8 polyarteritis polyarteritis NNP cord-028721-x6f26ahr 3712 9 nodosa nodosa RB cord-028721-x6f26ahr 3712 10 have have VBP cord-028721-x6f26ahr 3712 11 testicular testicular JJ cord-028721-x6f26ahr 3712 12 or or CC cord-028721-x6f26ahr 3712 13 epididymal epididymal JJ cord-028721-x6f26ahr 3712 14 involvement involvement NN cord-028721-x6f26ahr 3712 15 , , , cord-028721-x6f26ahr 3712 16 1575 1575 CD cord-028721-x6f26ahr 3712 17 but but CC cord-028721-x6f26ahr 3712 18 only only RB cord-028721-x6f26ahr 3712 19 2 2 CD cord-028721-x6f26ahr 3712 20 - - SYM cord-028721-x6f26ahr 3712 21 18 18 CD cord-028721-x6f26ahr 3712 22 % % NN cord-028721-x6f26ahr 3712 23 are be VBP cord-028721-x6f26ahr 3712 24 diagnosed diagnose VBN cord-028721-x6f26ahr 3712 25 during during IN cord-028721-x6f26ahr 3712 26 life life NN cord-028721-x6f26ahr 3712 27 . . . cord-028721-x6f26ahr 3713 1 Rarely rarely RB cord-028721-x6f26ahr 3713 2 , , , cord-028721-x6f26ahr 3713 3 testicular testicular JJ cord-028721-x6f26ahr 3713 4 or or CC cord-028721-x6f26ahr 3713 5 epididymal epididymal JJ cord-028721-x6f26ahr 3713 6 polyarteritis polyarteritis NN cord-028721-x6f26ahr 3713 7 nodosa nodosa RB cord-028721-x6f26ahr 3713 8 is be VBZ cord-028721-x6f26ahr 3713 9 the the DT cord-028721-x6f26ahr 3713 10 fi fi FW cord-028721-x6f26ahr 3713 11 rst rst NN cord-028721-x6f26ahr 3713 12 manifestation manifestation NN cord-028721-x6f26ahr 3713 13 of of IN cord-028721-x6f26ahr 3713 14 the the DT cord-028721-x6f26ahr 3713 15 disease disease NN cord-028721-x6f26ahr 3713 16 . . . cord-028721-x6f26ahr 3714 1 In in IN cord-028721-x6f26ahr 3714 2 these these DT cord-028721-x6f26ahr 3714 3 cases case NNS cord-028721-x6f26ahr 3714 4 the the DT cord-028721-x6f26ahr 3714 5 symptoms symptom NNS cord-028721-x6f26ahr 3714 6 may may MD cord-028721-x6f26ahr 3714 7 suggest suggest VB cord-028721-x6f26ahr 3714 8 orchitis orchitis NN cord-028721-x6f26ahr 3714 9 , , , cord-028721-x6f26ahr 3714 10 epididymitis epididymitis NN cord-028721-x6f26ahr 3714 11 , , , cord-028721-x6f26ahr 3714 12 testicular testicular NN cord-028721-x6f26ahr 3714 13 torsion torsion NN cord-028721-x6f26ahr 3714 14 , , , cord-028721-x6f26ahr 3714 15 or or CC cord-028721-x6f26ahr 3714 16 tumor tumor NN cord-028721-x6f26ahr 3714 17 . . . cord-028721-x6f26ahr 3715 1 [ [ -LRB- cord-028721-x6f26ahr 3715 2 1576 1576 CD cord-028721-x6f26ahr 3715 3 ] ] -RRB- cord-028721-x6f26ahr 3715 4 [ [ -LRB- cord-028721-x6f26ahr 3715 5 1577 1577 CD cord-028721-x6f26ahr 3715 6 ] ] -RRB- cord-028721-x6f26ahr 3715 7 [ [ -LRB- cord-028721-x6f26ahr 3715 8 1578 1578 CD cord-028721-x6f26ahr 3715 9 ] ] -RRB- cord-028721-x6f26ahr 3716 1 The the DT cord-028721-x6f26ahr 3716 2 testis testis NN cord-028721-x6f26ahr 3716 3 usually usually RB cord-028721-x6f26ahr 3716 4 shows show VBZ cord-028721-x6f26ahr 3716 5 arterial arterial JJ cord-028721-x6f26ahr 3716 6 lesions lesion NNS cord-028721-x6f26ahr 3716 7 in in IN cord-028721-x6f26ahr 3716 8 different different JJ cord-028721-x6f26ahr 3716 9 stages stage NNS cord-028721-x6f26ahr 3716 10 of of IN cord-028721-x6f26ahr 3716 11 evolution evolution NN cord-028721-x6f26ahr 3716 12 , , , cord-028721-x6f26ahr 3716 13 including include VBG cord-028721-x6f26ahr 3716 14 fi fi NN cord-028721-x6f26ahr 3716 15 brinoid brinoid JJ cord-028721-x6f26ahr 3716 16 necrosis necrosis NN cord-028721-x6f26ahr 3716 17 , , , cord-028721-x6f26ahr 3716 18 infl infl NNP cord-028721-x6f26ahr 3716 19 ammatory ammatory NNP cord-028721-x6f26ahr 3716 20 reaction reaction NN cord-028721-x6f26ahr 3716 21 , , , cord-028721-x6f26ahr 3716 22 thrombosis thrombosis NN cord-028721-x6f26ahr 3716 23 , , , cord-028721-x6f26ahr 3716 24 or or CC cord-028721-x6f26ahr 3716 25 aneurysm aneurysm NN cord-028721-x6f26ahr 3716 26 . . . cord-028721-x6f26ahr 3717 1 The the DT cord-028721-x6f26ahr 3717 2 parenchyma parenchyma NN cord-028721-x6f26ahr 3717 3 initially initially RB cord-028721-x6f26ahr 3717 4 has have VBZ cord-028721-x6f26ahr 3717 5 zones zone NNS cord-028721-x6f26ahr 3717 6 of of IN cord-028721-x6f26ahr 3717 7 infarction infarction NN cord-028721-x6f26ahr 3718 1 ( ( -LRB- cord-028721-x6f26ahr 3718 2 Fig Fig NNP cord-028721-x6f26ahr 3718 3 . . . cord-028721-x6f26ahr 3718 4 12 12 CD cord-028721-x6f26ahr 3718 5 - - SYM cord-028721-x6f26ahr 3718 6 164 164 CD cord-028721-x6f26ahr 3718 7 ) ) -RRB- cord-028721-x6f26ahr 3718 8 . . . cord-028721-x6f26ahr 3719 1 Histologic Histologic NNP cord-028721-x6f26ahr 3719 2 and and CC cord-028721-x6f26ahr 3719 3 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 3719 4 fi fi NN cord-028721-x6f26ahr 3719 5 ndings nding NNS cord-028721-x6f26ahr 3719 6 similar similar JJ cord-028721-x6f26ahr 3719 7 to to IN cord-028721-x6f26ahr 3719 8 those those DT cord-028721-x6f26ahr 3719 9 of of IN cord-028721-x6f26ahr 3719 10 polyarteritis polyarteritis NN cord-028721-x6f26ahr 3720 1 nodosa nodosa NNP cord-028721-x6f26ahr 3720 2 may may MD cord-028721-x6f26ahr 3720 3 occasionally occasionally RB cord-028721-x6f26ahr 3720 4 be be VB cord-028721-x6f26ahr 3720 5 observed observe VBN cord-028721-x6f26ahr 3720 6 in in IN cord-028721-x6f26ahr 3720 7 the the DT cord-028721-x6f26ahr 3720 8 testis testis NN cord-028721-x6f26ahr 3720 9 or or CC cord-028721-x6f26ahr 3720 10 the the DT cord-028721-x6f26ahr 3720 11 epididymis epididymis NN cord-028721-x6f26ahr 3720 12 without without IN cord-028721-x6f26ahr 3720 13 lesions lesion NNS cord-028721-x6f26ahr 3720 14 elsewhere elsewhere RB cord-028721-x6f26ahr 3720 15 ; ; : cord-028721-x6f26ahr 3720 16 this this DT cord-028721-x6f26ahr 3720 17 condition condition NN cord-028721-x6f26ahr 3720 18 is be VBZ cord-028721-x6f26ahr 3720 19 referred refer VBN cord-028721-x6f26ahr 3720 20 to to IN cord-028721-x6f26ahr 3720 21 as as RB cord-028721-x6f26ahr 3720 22 isolated isolate VBN cord-028721-x6f26ahr 3720 23 arteritis arteritis NN cord-028721-x6f26ahr 3720 24 of of IN cord-028721-x6f26ahr 3720 25 the the DT cord-028721-x6f26ahr 3720 26 testis testis NN cord-028721-x6f26ahr 3720 27 and and CC cord-028721-x6f26ahr 3720 28 epididymis epididymis NN cord-028721-x6f26ahr 3720 29 , , , cord-028721-x6f26ahr 3720 30 1579 1579 CD cord-028721-x6f26ahr 3720 31 and and CC cord-028721-x6f26ahr 3720 32 differs differ VBZ cord-028721-x6f26ahr 3720 33 from from IN cord-028721-x6f26ahr 3720 34 classic classic JJ cord-028721-x6f26ahr 3720 35 polyarteritis polyarteritis NN cord-028721-x6f26ahr 3720 36 by by IN cord-028721-x6f26ahr 3720 37 a a DT cord-028721-x6f26ahr 3720 38 lack lack NN cord-028721-x6f26ahr 3720 39 of of IN cord-028721-x6f26ahr 3720 40 vascular vascular JJ cord-028721-x6f26ahr 3720 41 thrombosis thrombosis NN cord-028721-x6f26ahr 3720 42 , , , cord-028721-x6f26ahr 3720 43 aneurysm aneurysm NN cord-028721-x6f26ahr 3720 44 , , , cord-028721-x6f26ahr 3720 45 or or CC cord-028721-x6f26ahr 3720 46 infarct infarct NN cord-028721-x6f26ahr 3720 47 . . . cord-028721-x6f26ahr 3721 1 The the DT cord-028721-x6f26ahr 3721 2 etiology etiology NN cord-028721-x6f26ahr 3721 3 of of IN cord-028721-x6f26ahr 3721 4 isolated isolated JJ cord-028721-x6f26ahr 3721 5 arteritis arteritis NN cord-028721-x6f26ahr 3721 6 is be VBZ cord-028721-x6f26ahr 3721 7 unknown unknown JJ cord-028721-x6f26ahr 3721 8 , , , cord-028721-x6f26ahr 3721 9 but but CC cord-028721-x6f26ahr 3721 10 the the DT cord-028721-x6f26ahr 3721 11 prognosis prognosis NN cord-028721-x6f26ahr 3721 12 is be VBZ cord-028721-x6f26ahr 3721 13 excellent excellent JJ cord-028721-x6f26ahr 3721 14 . . . cord-028721-x6f26ahr 3722 1 1580 1580 CD cord-028721-x6f26ahr 3723 1 The the DT cord-028721-x6f26ahr 3723 2 histologic histologic JJ cord-028721-x6f26ahr 3723 3 fi fi NN cord-028721-x6f26ahr 3723 4 ndings nding NNS cord-028721-x6f26ahr 3723 5 of of IN cord-028721-x6f26ahr 3723 6 necrotizing necrotize VBG cord-028721-x6f26ahr 3723 7 arteritis arteritis NN cord-028721-x6f26ahr 3723 8 in in IN cord-028721-x6f26ahr 3723 9 the the DT cord-028721-x6f26ahr 3723 10 testis testis NN cord-028721-x6f26ahr 3723 11 or or CC cord-028721-x6f26ahr 3723 12 epididymis epididymis NN cord-028721-x6f26ahr 3723 13 should should MD cord-028721-x6f26ahr 3723 14 be be VB cord-028721-x6f26ahr 3723 15 followed follow VBN cord-028721-x6f26ahr 3723 16 by by IN cord-028721-x6f26ahr 3723 17 clinical clinical JJ cord-028721-x6f26ahr 3723 18 , , , cord-028721-x6f26ahr 3723 19 hematologic hematologic JJ cord-028721-x6f26ahr 3723 20 , , , cord-028721-x6f26ahr 3723 21 and and CC cord-028721-x6f26ahr 3723 22 biochemical biochemical JJ cord-028721-x6f26ahr 3723 23 studies study NNS cord-028721-x6f26ahr 3723 24 to to TO cord-028721-x6f26ahr 3723 25 exclude exclude VB cord-028721-x6f26ahr 3723 26 systemic systemic JJ cord-028721-x6f26ahr 3723 27 arteritis arteritis NN cord-028721-x6f26ahr 3723 28 . . . cord-028721-x6f26ahr 3724 1 1581 1581 CD cord-028721-x6f26ahr 3724 2 , , , cord-028721-x6f26ahr 3724 3 1582 1582 CD cord-028721-x6f26ahr 3724 4 _SP cord-028721-x6f26ahr 3724 5 Torsion Torsion NNP cord-028721-x6f26ahr 3724 6 of of IN cord-028721-x6f26ahr 3724 7 the the DT cord-028721-x6f26ahr 3724 8 spermatic spermatic JJ cord-028721-x6f26ahr 3724 9 cord cord NN cord-028721-x6f26ahr 3724 10 is be VBZ cord-028721-x6f26ahr 3724 11 the the DT cord-028721-x6f26ahr 3724 12 most most RBS cord-028721-x6f26ahr 3724 13 frequent frequent JJ cord-028721-x6f26ahr 3724 14 cause cause NN cord-028721-x6f26ahr 3724 15 of of IN cord-028721-x6f26ahr 3724 16 testicular testicular NN cord-028721-x6f26ahr 3724 17 infarct infarct NN cord-028721-x6f26ahr 3724 18 , , , cord-028721-x6f26ahr 3724 19 followed follow VBN cord-028721-x6f26ahr 3724 20 by by IN cord-028721-x6f26ahr 3724 21 trauma trauma NN cord-028721-x6f26ahr 3724 22 , , , cord-028721-x6f26ahr 3724 23 incarcerated incarcerate VBN cord-028721-x6f26ahr 3724 24 inguinal inguinal JJ cord-028721-x6f26ahr 3724 25 hernia hernia NN cord-028721-x6f26ahr 3724 26 , , , cord-028721-x6f26ahr 3724 27 epididymitis epididymitis NN cord-028721-x6f26ahr 3724 28 , , , cord-028721-x6f26ahr 3724 29 and and CC cord-028721-x6f26ahr 3724 30 vasculitis vasculitis NN cord-028721-x6f26ahr 3724 31 . . . cord-028721-x6f26ahr 3725 1 Spermatic spermatic JJ cord-028721-x6f26ahr 3725 2 cord cord NN cord-028721-x6f26ahr 3725 3 torsion torsion NN cord-028721-x6f26ahr 3725 4 is be VBZ cord-028721-x6f26ahr 3725 5 a a DT cord-028721-x6f26ahr 3725 6 surgical surgical JJ cord-028721-x6f26ahr 3725 7 emergency emergency NN cord-028721-x6f26ahr 3725 8 . . . cord-028721-x6f26ahr 3726 1 If if IN cord-028721-x6f26ahr 3726 2 repair repair NN cord-028721-x6f26ahr 3726 3 is be VBZ cord-028721-x6f26ahr 3726 4 delayed delay VBN cord-028721-x6f26ahr 3726 5 more more JJR cord-028721-x6f26ahr 3726 6 than than IN cord-028721-x6f26ahr 3726 7 8 8 CD cord-028721-x6f26ahr 3726 8 hours hour NNS cord-028721-x6f26ahr 3726 9 , , , cord-028721-x6f26ahr 3726 10 testicular testicular JJ cord-028721-x6f26ahr 3726 11 viability viability NN cord-028721-x6f26ahr 3726 12 is be VBZ cord-028721-x6f26ahr 3726 13 usually usually RB cord-028721-x6f26ahr 3726 14 compromised compromise VBN cord-028721-x6f26ahr 3726 15 . . . cord-028721-x6f26ahr 3727 1 This this DT cord-028721-x6f26ahr 3727 2 disorder disorder NN cord-028721-x6f26ahr 3727 3 may may MD cord-028721-x6f26ahr 3727 4 appear appear VB cord-028721-x6f26ahr 3727 5 at at IN cord-028721-x6f26ahr 3727 6 any any DT cord-028721-x6f26ahr 3727 7 age age NN cord-028721-x6f26ahr 3727 8 , , , cord-028721-x6f26ahr 3727 9 but but CC cord-028721-x6f26ahr 3727 10 the the DT cord-028721-x6f26ahr 3727 11 Other other JJ cord-028721-x6f26ahr 3727 12 testicular testicular NN cord-028721-x6f26ahr 3727 13 and and CC cord-028721-x6f26ahr 3727 14 epididymal epididymal JJ cord-028721-x6f26ahr 3727 15 lesions lesion NNS cord-028721-x6f26ahr 3727 16 peaks peak NNS cord-028721-x6f26ahr 3727 17 of of IN cord-028721-x6f26ahr 3727 18 maximal maximal JJ cord-028721-x6f26ahr 3727 19 incidence incidence NN cord-028721-x6f26ahr 3727 20 are be VBP cord-028721-x6f26ahr 3727 21 the the DT cord-028721-x6f26ahr 3727 22 perinatal perinatal JJ cord-028721-x6f26ahr 3727 23 period period NN cord-028721-x6f26ahr 3727 24 and and CC cord-028721-x6f26ahr 3727 25 puberty puberty NN cord-028721-x6f26ahr 3727 26 . . . cord-028721-x6f26ahr 3728 1 1583 1583 CD cord-028721-x6f26ahr 3728 2 Factors factor NNS cord-028721-x6f26ahr 3728 3 that that WDT cord-028721-x6f26ahr 3728 4 predispose predispose VBP cord-028721-x6f26ahr 3728 5 to to IN cord-028721-x6f26ahr 3728 6 testicular testicular JJ cord-028721-x6f26ahr 3728 7 torsion torsion NN cord-028721-x6f26ahr 3728 8 are be VBP cord-028721-x6f26ahr 3728 9 anatomical anatomical JJ cord-028721-x6f26ahr 3728 10 anomalies anomaly NNS cord-028721-x6f26ahr 3728 11 in in IN cord-028721-x6f26ahr 3728 12 testicular testicular JJ cord-028721-x6f26ahr 3728 13 suspension suspension NN cord-028721-x6f26ahr 3728 14 and and CC cord-028721-x6f26ahr 3728 15 abnormal abnormal JJ cord-028721-x6f26ahr 3728 16 position position NN cord-028721-x6f26ahr 3728 17 of of IN cord-028721-x6f26ahr 3728 18 the the DT cord-028721-x6f26ahr 3728 19 testis testis NN cord-028721-x6f26ahr 3728 20 . . . cord-028721-x6f26ahr 3729 1 Many many JJ cord-028721-x6f26ahr 3729 2 men man NNS cord-028721-x6f26ahr 3729 3 with with IN cord-028721-x6f26ahr 3729 4 testicular testicular JJ cord-028721-x6f26ahr 3729 5 torsion torsion NN cord-028721-x6f26ahr 3729 6 have have VBP cord-028721-x6f26ahr 3729 7 an an DT cord-028721-x6f26ahr 3729 8 abnormally abnormally RB cord-028721-x6f26ahr 3729 9 high high JJ cord-028721-x6f26ahr 3729 10 refl refl NN cord-028721-x6f26ahr 3729 11 ection ection NN cord-028721-x6f26ahr 3729 12 of of IN cord-028721-x6f26ahr 3729 13 the the DT cord-028721-x6f26ahr 3729 14 tunica tunica NNP cord-028721-x6f26ahr 3729 15 vaginalis vaginalis NNP cord-028721-x6f26ahr 3729 16 , , , cord-028721-x6f26ahr 3729 17 giving give VBG cord-028721-x6f26ahr 3729 18 rise rise NN cord-028721-x6f26ahr 3729 19 to to IN cord-028721-x6f26ahr 3729 20 the the DT cord-028721-x6f26ahr 3729 21 deformity deformity NN cord-028721-x6f26ahr 3729 22 known know VBN cord-028721-x6f26ahr 3729 23 as as IN cord-028721-x6f26ahr 3729 24 ' ' `` cord-028721-x6f26ahr 3729 25 bell bell NNP cord-028721-x6f26ahr 3729 26 - - HYPH cord-028721-x6f26ahr 3729 27 clapper clapper NNP cord-028721-x6f26ahr 3729 28 . . . cord-028721-x6f26ahr 3729 29 ' ' '' cord-028721-x6f26ahr 3730 1 Other other JJ cord-028721-x6f26ahr 3730 2 anomalies anomaly NNS cord-028721-x6f26ahr 3730 3 include include VBP cord-028721-x6f26ahr 3730 4 elongated elongated JJ cord-028721-x6f26ahr 3730 5 mesorchium mesorchium NN cord-028721-x6f26ahr 3730 6 , , , cord-028721-x6f26ahr 3730 7 separation separation NN cord-028721-x6f26ahr 3730 8 between between IN cord-028721-x6f26ahr 3730 9 the the DT cord-028721-x6f26ahr 3730 10 epididymis epididymis NN cord-028721-x6f26ahr 3730 11 and and CC cord-028721-x6f26ahr 3730 12 testis testis NN cord-028721-x6f26ahr 3730 13 , , , cord-028721-x6f26ahr 3730 14 and and CC cord-028721-x6f26ahr 3730 15 absent absent JJ cord-028721-x6f26ahr 3730 16 or or CC cord-028721-x6f26ahr 3730 17 very very RB cord-028721-x6f26ahr 3730 18 elongated elongated JJ cord-028721-x6f26ahr 3730 19 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3730 20 . . . cord-028721-x6f26ahr 3731 1 The the DT cord-028721-x6f26ahr 3731 2 frequency frequency NN cord-028721-x6f26ahr 3731 3 of of IN cord-028721-x6f26ahr 3731 4 testicular testicular JJ cord-028721-x6f26ahr 3731 5 torsion torsion NN cord-028721-x6f26ahr 3731 6 is be VBZ cord-028721-x6f26ahr 3731 7 higher high JJR cord-028721-x6f26ahr 3731 8 in in IN cord-028721-x6f26ahr 3731 9 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3731 10 and and CC cord-028721-x6f26ahr 3731 11 retractile retractile JJ cord-028721-x6f26ahr 3731 12 testes testis NNS cord-028721-x6f26ahr 3731 13 than than IN cord-028721-x6f26ahr 3731 14 in in IN cord-028721-x6f26ahr 3731 15 normal normal JJ cord-028721-x6f26ahr 3731 16 testes testis NNS cord-028721-x6f26ahr 3731 17 . . . cord-028721-x6f26ahr 3732 1 There there EX cord-028721-x6f26ahr 3732 2 are be VBP cord-028721-x6f26ahr 3732 3 two two CD cord-028721-x6f26ahr 3732 4 classic classic JJ cord-028721-x6f26ahr 3732 5 anatomic anatomic JJ cord-028721-x6f26ahr 3732 6 forms form NNS cord-028721-x6f26ahr 3732 7 of of IN cord-028721-x6f26ahr 3732 8 testicular testicular JJ cord-028721-x6f26ahr 3732 9 torsion torsion NN cord-028721-x6f26ahr 3732 10 : : : cord-028721-x6f26ahr 3732 11 high high JJ cord-028721-x6f26ahr 3732 12 ( ( -LRB- cord-028721-x6f26ahr 3732 13 supravaginal supravaginal JJ cord-028721-x6f26ahr 3732 14 or or CC cord-028721-x6f26ahr 3732 15 extravaginal extravaginal JJ cord-028721-x6f26ahr 3732 16 ) ) -RRB- cord-028721-x6f26ahr 3732 17 and and CC cord-028721-x6f26ahr 3732 18 low low JJ cord-028721-x6f26ahr 3732 19 ( ( -LRB- cord-028721-x6f26ahr 3732 20 intravaginal intravaginal JJ cord-028721-x6f26ahr 3732 21 ) ) -RRB- cord-028721-x6f26ahr 3732 22 . . . cord-028721-x6f26ahr 3733 1 Each each DT cord-028721-x6f26ahr 3733 2 appears appear VBZ cord-028721-x6f26ahr 3733 3 at at IN cord-028721-x6f26ahr 3733 4 a a DT cord-028721-x6f26ahr 3733 5 different different JJ cord-028721-x6f26ahr 3733 6 age age NN cord-028721-x6f26ahr 3733 7 . . . cord-028721-x6f26ahr 3734 1 Extravaginal extravaginal JJ cord-028721-x6f26ahr 3734 2 torsion torsion NN cord-028721-x6f26ahr 3734 3 typically typically RB cord-028721-x6f26ahr 3734 4 occurs occur VBZ cord-028721-x6f26ahr 3734 5 in in IN cord-028721-x6f26ahr 3734 6 infancy infancy NN cord-028721-x6f26ahr 3734 7 and and CC cord-028721-x6f26ahr 3734 8 childhood childhood NN cord-028721-x6f26ahr 3734 9 , , , cord-028721-x6f26ahr 3734 10 whereas whereas IN cord-028721-x6f26ahr 3734 11 intravaginal intravaginal JJ cord-028721-x6f26ahr 3734 12 torsion torsion NN cord-028721-x6f26ahr 3734 13 is be VBZ cord-028721-x6f26ahr 3734 14 more more RBR cord-028721-x6f26ahr 3734 15 frequent frequent JJ cord-028721-x6f26ahr 3734 16 at at IN cord-028721-x6f26ahr 3734 17 puberty puberty NN cord-028721-x6f26ahr 3734 18 and and CC cord-028721-x6f26ahr 3734 19 adulthood adulthood NN cord-028721-x6f26ahr 3734 20 . . . cord-028721-x6f26ahr 3735 1 Neonatal neonatal JJ cord-028721-x6f26ahr 3735 2 torsion torsion NN cord-028721-x6f26ahr 3735 3 is be VBZ cord-028721-x6f26ahr 3735 4 bilateral bilateral JJ cord-028721-x6f26ahr 3735 5 in in IN cord-028721-x6f26ahr 3735 6 12 12 CD cord-028721-x6f26ahr 3735 7 - - SYM cord-028721-x6f26ahr 3735 8 21 21 CD cord-028721-x6f26ahr 3735 9 % % NN cord-028721-x6f26ahr 3735 10 of of IN cord-028721-x6f26ahr 3735 11 cases case NNS cord-028721-x6f26ahr 3735 12 . . . cord-028721-x6f26ahr 3736 1 1584 1584 CD cord-028721-x6f26ahr 3737 1 Most Most JJS cord-028721-x6f26ahr 3737 2 torsion torsion NN cord-028721-x6f26ahr 3737 3 observed observe VBD cord-028721-x6f26ahr 3737 4 on on IN cord-028721-x6f26ahr 3737 5 the the DT cord-028721-x6f26ahr 3737 6 fi fi NN cord-028721-x6f26ahr 3737 7 rst rst NN cord-028721-x6f26ahr 3737 8 of of IN cord-028721-x6f26ahr 3737 9 life life NN cord-028721-x6f26ahr 3737 10 is be VBZ cord-028721-x6f26ahr 3737 11 intrauterine intrauterine JJ cord-028721-x6f26ahr 3737 12 . . . cord-028721-x6f26ahr 3738 1 1585 1585 CD cord-028721-x6f26ahr 3739 1 Pubertal pubertal JJ cord-028721-x6f26ahr 3739 2 and and CC cord-028721-x6f26ahr 3739 3 adult adult NN cord-028721-x6f26ahr 3739 4 torsion torsion NN cord-028721-x6f26ahr 3739 5 causes cause VBZ cord-028721-x6f26ahr 3739 6 testicular testicular JJ cord-028721-x6f26ahr 3739 7 pain pain NN cord-028721-x6f26ahr 3739 8 that that WDT cord-028721-x6f26ahr 3739 9 may may MD cord-028721-x6f26ahr 3739 10 radiate radiate VB cord-028721-x6f26ahr 3739 11 to to IN cord-028721-x6f26ahr 3739 12 the the DT cord-028721-x6f26ahr 3739 13 abdomen abdomen NN cord-028721-x6f26ahr 3739 14 or or CC cord-028721-x6f26ahr 3739 15 other other JJ cord-028721-x6f26ahr 3739 16 sites site NNS cord-028721-x6f26ahr 3739 17 . . . cord-028721-x6f26ahr 3740 1 About about RB cord-028721-x6f26ahr 3740 2 36 36 CD cord-028721-x6f26ahr 3740 3 % % NN cord-028721-x6f26ahr 3740 4 of of IN cord-028721-x6f26ahr 3740 5 patients patient NNS cord-028721-x6f26ahr 3740 6 have have VBP cord-028721-x6f26ahr 3740 7 a a DT cord-028721-x6f26ahr 3740 8 previous previous JJ cord-028721-x6f26ahr 3740 9 history history NN cord-028721-x6f26ahr 3740 10 of of IN cord-028721-x6f26ahr 3740 11 pain pain NN cord-028721-x6f26ahr 3740 12 or or CC cord-028721-x6f26ahr 3740 13 swelling swell VBG cord-028721-x6f26ahr 3740 14 in in IN cord-028721-x6f26ahr 3740 15 one one CD cord-028721-x6f26ahr 3740 16 or or CC cord-028721-x6f26ahr 3740 17 both both DT cord-028721-x6f26ahr 3740 18 testes testis NNS cord-028721-x6f26ahr 3740 19 . . . cord-028721-x6f26ahr 3741 1 The the DT cord-028721-x6f26ahr 3741 2 differential differential JJ cord-028721-x6f26ahr 3741 3 diagnosis diagnosis NN cord-028721-x6f26ahr 3741 4 includes include VBZ cord-028721-x6f26ahr 3741 5 all all DT cord-028721-x6f26ahr 3741 6 causes cause NNS cord-028721-x6f26ahr 3741 7 of of IN cord-028721-x6f26ahr 3741 8 acute acute JJ cord-028721-x6f26ahr 3741 9 scrotum scrotum NN cord-028721-x6f26ahr 3741 10 . . . cord-028721-x6f26ahr 3742 1 1586 1586 CD cord-028721-x6f26ahr 3742 2 , , , cord-028721-x6f26ahr 3742 3 1587 1587 CD cord-028721-x6f26ahr 3742 4 Torsion torsion NN cord-028721-x6f26ahr 3742 5 causes cause VBZ cord-028721-x6f26ahr 3742 6 hemorrhagic hemorrhagic JJ cord-028721-x6f26ahr 3742 7 infarction infarction NN cord-028721-x6f26ahr 3742 8 of of IN cord-028721-x6f26ahr 3742 9 the the DT cord-028721-x6f26ahr 3742 10 testis testis NN cord-028721-x6f26ahr 3742 11 ( ( -LRB- cord-028721-x6f26ahr 3742 12 Fig fig NN cord-028721-x6f26ahr 3742 13 . . . cord-028721-x6f26ahr 3742 14 _SP cord-028721-x6f26ahr 3743 1 12 12 CD cord-028721-x6f26ahr 3743 2 - - SYM cord-028721-x6f26ahr 3743 3 165 165 CD cord-028721-x6f26ahr 3743 4 ) ) -RRB- cord-028721-x6f26ahr 3743 5 . . . cord-028721-x6f26ahr 3744 1 In in IN cord-028721-x6f26ahr 3744 2 old old JJ cord-028721-x6f26ahr 3744 3 neonatal neonatal JJ cord-028721-x6f26ahr 3744 4 torsion torsion NN cord-028721-x6f26ahr 3744 5 , , , cord-028721-x6f26ahr 3744 6 the the DT cord-028721-x6f26ahr 3744 7 histological histological JJ cord-028721-x6f26ahr 3744 8 fi fi NN cord-028721-x6f26ahr 3744 9 ndings nding NNS cord-028721-x6f26ahr 3744 10 are be VBP cord-028721-x6f26ahr 3744 11 so so RB cord-028721-x6f26ahr 3744 12 advanced advanced JJ cord-028721-x6f26ahr 3744 13 that that IN cord-028721-x6f26ahr 3744 14 only only RB cord-028721-x6f26ahr 3744 15 collagenized collagenized JJ cord-028721-x6f26ahr 3744 16 tissue tissue NN cord-028721-x6f26ahr 3744 17 containing contain VBG cord-028721-x6f26ahr 3744 18 calcium calcium NN cord-028721-x6f26ahr 3744 19 and and CC cord-028721-x6f26ahr 3744 20 hemosiderin hemosiderin NNP cord-028721-x6f26ahr 3744 21 deposits deposit NNS cord-028721-x6f26ahr 3744 22 is be VBZ cord-028721-x6f26ahr 3744 23 seen see VBN cord-028721-x6f26ahr 3744 24 . . . cord-028721-x6f26ahr 3745 1 In in IN cord-028721-x6f26ahr 3745 2 adults adult NNS cord-028721-x6f26ahr 3745 3 , , , cord-028721-x6f26ahr 3745 4 three three CD cord-028721-x6f26ahr 3745 5 degrees degree NNS cord-028721-x6f26ahr 3745 6 of of IN cord-028721-x6f26ahr 3745 7 histological histological JJ cord-028721-x6f26ahr 3745 8 lesion lesion NN cord-028721-x6f26ahr 3745 9 may may MD cord-028721-x6f26ahr 3745 10 be be VB cord-028721-x6f26ahr 3745 11 distinguished distinguish VBN cord-028721-x6f26ahr 3745 12 . . . cord-028721-x6f26ahr 3746 1 1588 1588 CD cord-028721-x6f26ahr 3747 1 Degree degree NN cord-028721-x6f26ahr 3747 2 I i NN cord-028721-x6f26ahr 3747 3 ( ( -LRB- cord-028721-x6f26ahr 3747 4 26.5 26.5 CD cord-028721-x6f26ahr 3747 5 % % NN cord-028721-x6f26ahr 3747 6 of of IN cord-028721-x6f26ahr 3747 7 adult adult NN cord-028721-x6f26ahr 3747 8 twisted twisted JJ cord-028721-x6f26ahr 3747 9 testes testis NNS cord-028721-x6f26ahr 3747 10 ) ) -RRB- cord-028721-x6f26ahr 3747 11 is be VBZ cord-028721-x6f26ahr 3747 12 characterized characterize VBN cord-028721-x6f26ahr 3747 13 by by IN cord-028721-x6f26ahr 3747 14 edema edema NN cord-028721-x6f26ahr 3747 15 , , , cord-028721-x6f26ahr 3747 16 vascular vascular JJ cord-028721-x6f26ahr 3747 17 congestion congestion NN cord-028721-x6f26ahr 3747 18 , , , cord-028721-x6f26ahr 3747 19 and and CC cord-028721-x6f26ahr 3747 20 focal focal JJ cord-028721-x6f26ahr 3747 21 hemorrhage hemorrhage NN cord-028721-x6f26ahr 3747 22 . . . cord-028721-x6f26ahr 3748 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 3748 2 tubules tubule NNS cord-028721-x6f26ahr 3748 3 are be VBP cord-028721-x6f26ahr 3748 4 dilated dilated JJ cord-028721-x6f26ahr 3748 5 , , , cord-028721-x6f26ahr 3748 6 with with IN cord-028721-x6f26ahr 3748 7 sloughed slough VBN cord-028721-x6f26ahr 3748 8 immature immature JJ cord-028721-x6f26ahr 3748 9 germ germ NN cord-028721-x6f26ahr 3748 10 cells cell NNS cord-028721-x6f26ahr 3748 11 , , , cord-028721-x6f26ahr 3748 12 apical apical JJ cord-028721-x6f26ahr 3748 13 vacuolation vacuolation NN cord-028721-x6f26ahr 3748 14 of of IN cord-028721-x6f26ahr 3748 15 Sertoli Sertoli NNP cord-028721-x6f26ahr 3748 16 cells cell NNS cord-028721-x6f26ahr 3748 17 , , , cord-028721-x6f26ahr 3748 18 and and CC cord-028721-x6f26ahr 3748 19 dilated dilated JJ cord-028721-x6f26ahr 3748 20 lymphatic lymphatic JJ cord-028721-x6f26ahr 3748 21 vessels vessel NNS cord-028721-x6f26ahr 3748 22 . . . cord-028721-x6f26ahr 3749 1 1589 1589 CD cord-028721-x6f26ahr 3749 2 Degree Degree NNP cord-028721-x6f26ahr 3749 3 II II NNP cord-028721-x6f26ahr 3749 4 ( ( -LRB- cord-028721-x6f26ahr 3749 5 26.5 26.5 CD cord-028721-x6f26ahr 3749 6 % % NN cord-028721-x6f26ahr 3749 7 of of IN cord-028721-x6f26ahr 3749 8 testes testis NNS cord-028721-x6f26ahr 3749 9 ) ) -RRB- cord-028721-x6f26ahr 3749 10 has have VBZ cord-028721-x6f26ahr 3749 11 pronounced pronounce VBN cord-028721-x6f26ahr 3749 12 interstitial interstitial JJ cord-028721-x6f26ahr 3749 13 hemorrhage hemorrhage NN cord-028721-x6f26ahr 3749 14 and and CC cord-028721-x6f26ahr 3749 15 sloughing sloughing NN cord-028721-x6f26ahr 3749 16 of of IN cord-028721-x6f26ahr 3749 17 all all DT cord-028721-x6f26ahr 3749 18 germ germ NN cord-028721-x6f26ahr 3749 19 cell cell NN cord-028721-x6f26ahr 3749 20 types type NNS cord-028721-x6f26ahr 3749 21 in in IN cord-028721-x6f26ahr 3749 22 the the DT cord-028721-x6f26ahr 3749 23 seminiferous seminiferous JJ cord-028721-x6f26ahr 3749 24 tubules tubule NNS cord-028721-x6f26ahr 3749 25 . . . cord-028721-x6f26ahr 3750 1 The the DT cord-028721-x6f26ahr 3750 2 lesion lesion NN cord-028721-x6f26ahr 3750 3 is be VBZ cord-028721-x6f26ahr 3750 4 more more RBR cord-028721-x6f26ahr 3750 5 severe severe JJ cord-028721-x6f26ahr 3750 6 in in IN cord-028721-x6f26ahr 3750 7 the the DT cord-028721-x6f26ahr 3750 8 center center NN cord-028721-x6f26ahr 3750 9 of of IN cord-028721-x6f26ahr 3750 10 the the DT cord-028721-x6f26ahr 3750 11 testis testis NN cord-028721-x6f26ahr 3750 12 , , , cord-028721-x6f26ahr 3750 13 and and CC cord-028721-x6f26ahr 3750 14 thus thus RB cord-028721-x6f26ahr 3750 15 biopsy biopsy NNP cord-028721-x6f26ahr 3750 16 might may MD cord-028721-x6f26ahr 3750 17 provide provide VB cord-028721-x6f26ahr 3750 18 erroneous erroneous JJ cord-028721-x6f26ahr 3750 19 information information NN cord-028721-x6f26ahr 3750 20 ( ( -LRB- cord-028721-x6f26ahr 3750 21 Fig Fig NNP cord-028721-x6f26ahr 3750 22 . . . cord-028721-x6f26ahr 3750 23 12 12 CD cord-028721-x6f26ahr 3750 24 - - SYM cord-028721-x6f26ahr 3750 25 166 166 CD cord-028721-x6f26ahr 3750 26 ) ) -RRB- cord-028721-x6f26ahr 3750 27 . . . cord-028721-x6f26ahr 3751 1 Degree degree NN cord-028721-x6f26ahr 3751 2 III iii CD cord-028721-x6f26ahr 3751 3 lesions lesion NNS cord-028721-x6f26ahr 3751 4 ( ( -LRB- cord-028721-x6f26ahr 3751 5 45 45 CD cord-028721-x6f26ahr 3751 6 % % NN cord-028721-x6f26ahr 3751 7 of of IN cord-028721-x6f26ahr 3751 8 testes testis NNS cord-028721-x6f26ahr 3751 9 ) ) -RRB- cord-028721-x6f26ahr 3751 10 are be VBP cord-028721-x6f26ahr 3751 11 characterized characterize VBN cord-028721-x6f26ahr 3751 12 by by IN cord-028721-x6f26ahr 3751 13 necrosis necrosis NN cord-028721-x6f26ahr 3751 14 of of IN cord-028721-x6f26ahr 3751 15 the the DT cord-028721-x6f26ahr 3751 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 3751 17 tubular tubular JJ cord-028721-x6f26ahr 3751 18 cell cell NN cord-028721-x6f26ahr 3751 19 layers layer NNS cord-028721-x6f26ahr 3751 20 . . . cord-028721-x6f26ahr 3752 1 There there EX cord-028721-x6f26ahr 3752 2 is be VBZ cord-028721-x6f26ahr 3752 3 often often RB cord-028721-x6f26ahr 3752 4 a a DT cord-028721-x6f26ahr 3752 5 correlation correlation NN cord-028721-x6f26ahr 3752 6 between between IN cord-028721-x6f26ahr 3752 7 the the DT cord-028721-x6f26ahr 3752 8 time time NN cord-028721-x6f26ahr 3752 9 interval interval NN cord-028721-x6f26ahr 3752 10 of of IN cord-028721-x6f26ahr 3752 11 torsion torsion NN cord-028721-x6f26ahr 3752 12 and and CC cord-028721-x6f26ahr 3752 13 the the DT cord-028721-x6f26ahr 3752 14 degree degree NN cord-028721-x6f26ahr 3752 15 of of IN cord-028721-x6f26ahr 3752 16 the the DT cord-028721-x6f26ahr 3752 17 histologic histologic JJ cord-028721-x6f26ahr 3752 18 lesion lesion NN cord-028721-x6f26ahr 3752 19 . . . cord-028721-x6f26ahr 3753 1 1590 1590 CD cord-028721-x6f26ahr 3753 2 Degree Degree NNP cord-028721-x6f26ahr 3753 3 I -PRON- PRP cord-028721-x6f26ahr 3753 4 appears appear VBZ cord-028721-x6f26ahr 3753 5 in in IN cord-028721-x6f26ahr 3753 6 torsion torsion NN cord-028721-x6f26ahr 3753 7 of of IN cord-028721-x6f26ahr 3753 8 less less JJR cord-028721-x6f26ahr 3753 9 than than IN cord-028721-x6f26ahr 3753 10 4 4 CD cord-028721-x6f26ahr 3753 11 hours hour NNS cord-028721-x6f26ahr 3753 12 ' ' POS cord-028721-x6f26ahr 3753 13 duration duration NN cord-028721-x6f26ahr 3753 14 , , , cord-028721-x6f26ahr 3753 15 degree degree NN cord-028721-x6f26ahr 3753 16 II ii NN cord-028721-x6f26ahr 3753 17 in in IN cord-028721-x6f26ahr 3753 18 torsion torsion NN cord-028721-x6f26ahr 3753 19 of of IN cord-028721-x6f26ahr 3753 20 between between IN cord-028721-x6f26ahr 3753 21 4 4 CD cord-028721-x6f26ahr 3753 22 and and CC cord-028721-x6f26ahr 3753 23 8 8 CD cord-028721-x6f26ahr 3753 24 hours hour NNS cord-028721-x6f26ahr 3753 25 , , , cord-028721-x6f26ahr 3753 26 and and CC cord-028721-x6f26ahr 3753 27 degree degree NN cord-028721-x6f26ahr 3753 28 III iii CD cord-028721-x6f26ahr 3753 29 in in IN cord-028721-x6f26ahr 3753 30 torsion torsion NN cord-028721-x6f26ahr 3753 31 of of IN cord-028721-x6f26ahr 3753 32 more more JJR cord-028721-x6f26ahr 3753 33 than than IN cord-028721-x6f26ahr 3753 34 12 12 CD cord-028721-x6f26ahr 3753 35 hours hour NNS cord-028721-x6f26ahr 3753 36 . . . cord-028721-x6f26ahr 3754 1 Nevertheless nevertheless RB cord-028721-x6f26ahr 3754 2 , , , cord-028721-x6f26ahr 3754 3 there there EX cord-028721-x6f26ahr 3754 4 are be VBP cord-028721-x6f26ahr 3754 5 some some DT cord-028721-x6f26ahr 3754 6 exceptions exception NNS cord-028721-x6f26ahr 3754 7 that that WDT cord-028721-x6f26ahr 3754 8 could could MD cord-028721-x6f26ahr 3754 9 probably probably RB cord-028721-x6f26ahr 3754 10 be be VB cord-028721-x6f26ahr 3754 11 related relate VBN cord-028721-x6f26ahr 3754 12 , , , cord-028721-x6f26ahr 3754 13 among among IN cord-028721-x6f26ahr 3754 14 other other JJ cord-028721-x6f26ahr 3754 15 factors factor NNS cord-028721-x6f26ahr 3754 16 , , , cord-028721-x6f26ahr 3754 17 to to IN cord-028721-x6f26ahr 3754 18 the the DT cord-028721-x6f26ahr 3754 19 number number NN cord-028721-x6f26ahr 3754 20 of of IN cord-028721-x6f26ahr 3754 21 twists twist NNS cord-028721-x6f26ahr 3754 22 in in IN cord-028721-x6f26ahr 3754 23 the the DT cord-028721-x6f26ahr 3754 24 torsed torsed JJ cord-028721-x6f26ahr 3754 25 spermatic spermatic JJ cord-028721-x6f26ahr 3754 26 cord cord NN cord-028721-x6f26ahr 3754 27 ( ( -LRB- cord-028721-x6f26ahr 3754 28 degrees degree NNS cord-028721-x6f26ahr 3754 29 of of IN cord-028721-x6f26ahr 3754 30 testicular testicular JJ cord-028721-x6f26ahr 3754 31 rotation rotation NN cord-028721-x6f26ahr 3754 32 ) ) -RRB- cord-028721-x6f26ahr 3754 33 . . . cord-028721-x6f26ahr 3755 1 The the DT cord-028721-x6f26ahr 3755 2 testicular testicular NN cord-028721-x6f26ahr 3755 3 salvage salvage NN cord-028721-x6f26ahr 3755 4 rate rate NN cord-028721-x6f26ahr 3755 5 , , , cord-028721-x6f26ahr 3755 6 defi defi NNP cord-028721-x6f26ahr 3755 7 ned ned NNP cord-028721-x6f26ahr 3755 8 as as IN cord-028721-x6f26ahr 3755 9 testicular testicular JJ cord-028721-x6f26ahr 3755 10 growth growth NN cord-028721-x6f26ahr 3755 11 and and CC cord-028721-x6f26ahr 3755 12 development development NN cord-028721-x6f26ahr 3755 13 that that WDT cord-028721-x6f26ahr 3755 14 refl refl NNP cord-028721-x6f26ahr 3755 15 ects ects NNP cord-028721-x6f26ahr 3755 16 the the DT cord-028721-x6f26ahr 3755 17 age age NN cord-028721-x6f26ahr 3755 18 of of IN cord-028721-x6f26ahr 3755 19 the the DT cord-028721-x6f26ahr 3755 20 patient patient NN cord-028721-x6f26ahr 3755 21 and and CC cord-028721-x6f26ahr 3755 22 the the DT cord-028721-x6f26ahr 3755 23 contralateral contralateral JJ cord-028721-x6f26ahr 3755 24 testis testis NN cord-028721-x6f26ahr 3755 25 , , , cord-028721-x6f26ahr 3755 26 is be VBZ cord-028721-x6f26ahr 3755 27 around around RB cord-028721-x6f26ahr 3755 28 50 50 CD cord-028721-x6f26ahr 3755 29 % % NN cord-028721-x6f26ahr 3755 30 in in IN cord-028721-x6f26ahr 3755 31 all all DT cord-028721-x6f26ahr 3755 32 cases case NNS cord-028721-x6f26ahr 3755 33 of of IN cord-028721-x6f26ahr 3755 34 testicular testicular JJ cord-028721-x6f26ahr 3755 35 torsion torsion NN cord-028721-x6f26ahr 3755 36 . . . cord-028721-x6f26ahr 3756 1 1591 1591 CD cord-028721-x6f26ahr 3756 2 Testes testis NNS cord-028721-x6f26ahr 3756 3 that that WDT cord-028721-x6f26ahr 3756 4 do do VBP cord-028721-x6f26ahr 3756 5 not not RB cord-028721-x6f26ahr 3756 6 bleed bleed VB cord-028721-x6f26ahr 3756 7 into into IN cord-028721-x6f26ahr 3756 8 the the DT cord-028721-x6f26ahr 3756 9 albugineal albugineal NN cord-028721-x6f26ahr 3756 10 incision incision NN cord-028721-x6f26ahr 3756 11 within within IN cord-028721-x6f26ahr 3756 12 10 10 CD cord-028721-x6f26ahr 3756 13 minutes minute NNS cord-028721-x6f26ahr 3756 14 are be VBP cord-028721-x6f26ahr 3756 15 assumed assume VBN cord-028721-x6f26ahr 3756 16 to to TO cord-028721-x6f26ahr 3756 17 be be VB cord-028721-x6f26ahr 3756 18 non non JJ cord-028721-x6f26ahr 3756 19 - - JJ cord-028721-x6f26ahr 3756 20 viable viable JJ cord-028721-x6f26ahr 3756 21 and and CC cord-028721-x6f26ahr 3756 22 should should MD cord-028721-x6f26ahr 3756 23 be be VB cord-028721-x6f26ahr 3756 24 removed remove VBN cord-028721-x6f26ahr 3756 25 . . . cord-028721-x6f26ahr 3757 1 1592 1592 CD cord-028721-x6f26ahr 3757 2 Little little JJ cord-028721-x6f26ahr 3757 3 attention attention NN cord-028721-x6f26ahr 3757 4 has have VBZ cord-028721-x6f26ahr 3757 5 been be VBN cord-028721-x6f26ahr 3757 6 paid pay VBN cord-028721-x6f26ahr 3757 7 to to IN cord-028721-x6f26ahr 3757 8 intermittent intermittent JJ cord-028721-x6f26ahr 3757 9 testicular testicular JJ cord-028721-x6f26ahr 3757 10 torsion torsion NN cord-028721-x6f26ahr 3757 11 . . . cord-028721-x6f26ahr 3758 1 Early early JJ cord-028721-x6f26ahr 3758 2 orchiopexy orchiopexy NN cord-028721-x6f26ahr 3758 3 may may MD cord-028721-x6f26ahr 3758 4 save save VB cord-028721-x6f26ahr 3758 5 these these DT cord-028721-x6f26ahr 3758 6 testes testis NNS cord-028721-x6f26ahr 3758 7 , , , cord-028721-x6f26ahr 3758 8 but but CC cord-028721-x6f26ahr 3758 9 after after IN cord-028721-x6f26ahr 3758 10 surgery surgery NN cord-028721-x6f26ahr 3758 11 , , , cord-028721-x6f26ahr 3758 12 the the DT cord-028721-x6f26ahr 3758 13 testis testis NN cord-028721-x6f26ahr 3758 14 becomes become VBZ cord-028721-x6f26ahr 3758 15 small small JJ cord-028721-x6f26ahr 3758 16 and and CC cord-028721-x6f26ahr 3758 17 excessively excessively RB cord-028721-x6f26ahr 3758 18 mobile mobile JJ cord-028721-x6f26ahr 3758 19 , , , cord-028721-x6f26ahr 3758 20 and and CC cord-028721-x6f26ahr 3758 21 most most JJS cord-028721-x6f26ahr 3758 22 have have VB cord-028721-x6f26ahr 3758 23 the the DT cord-028721-x6f26ahr 3758 24 bell bell NN cord-028721-x6f26ahr 3758 25 - - HYPH cord-028721-x6f26ahr 3758 26 clapper clapper NN cord-028721-x6f26ahr 3758 27 deformity deformity NN cord-028721-x6f26ahr 3758 28 . . . cord-028721-x6f26ahr 3759 1 1593 1593 CD cord-028721-x6f26ahr 3760 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 3760 2 tubules tubule NNS cord-028721-x6f26ahr 3760 3 are be VBP cord-028721-x6f26ahr 3760 4 devoid devoid JJ cord-028721-x6f26ahr 3760 5 of of IN cord-028721-x6f26ahr 3760 6 germ germ NN cord-028721-x6f26ahr 3760 7 cells cell NNS cord-028721-x6f26ahr 3760 8 and and CC cord-028721-x6f26ahr 3760 9 have have VBP cord-028721-x6f26ahr 3760 10 hyalinized hyalinize VBN cord-028721-x6f26ahr 3760 11 walls wall NNS cord-028721-x6f26ahr 3760 12 . . . cord-028721-x6f26ahr 3761 1 Some some DT cord-028721-x6f26ahr 3761 2 adults adult NNS cord-028721-x6f26ahr 3761 3 with with IN cord-028721-x6f26ahr 3761 4 untreated untreated JJ cord-028721-x6f26ahr 3761 5 testicular testicular JJ cord-028721-x6f26ahr 3761 6 torsion torsion NN cord-028721-x6f26ahr 3761 7 develop develop VBP cord-028721-x6f26ahr 3761 8 lipomembranous lipomembranous JJ cord-028721-x6f26ahr 3761 9 fat fat JJ cord-028721-x6f26ahr 3761 10 necrosis necrosis NN cord-028721-x6f26ahr 3761 11 of of IN cord-028721-x6f26ahr 3761 12 the the DT cord-028721-x6f26ahr 3761 13 spermatic spermatic JJ cord-028721-x6f26ahr 3761 14 cord cord NN cord-028721-x6f26ahr 3761 15 . . . cord-028721-x6f26ahr 3762 1 1594 1594 CD cord-028721-x6f26ahr 3762 2 Patients patient NNS cord-028721-x6f26ahr 3762 3 seek seek VBP cord-028721-x6f26ahr 3762 4 help help NN cord-028721-x6f26ahr 3762 5 for for IN cord-028721-x6f26ahr 3762 6 pain pain NN cord-028721-x6f26ahr 3762 7 in in IN cord-028721-x6f26ahr 3762 8 the the DT cord-028721-x6f26ahr 3762 9 high high JJ cord-028721-x6f26ahr 3762 10 scrotum scrotum NN cord-028721-x6f26ahr 3762 11 . . . cord-028721-x6f26ahr 3763 1 At at IN cord-028721-x6f26ahr 3763 2 this this DT cord-028721-x6f26ahr 3763 3 level level NN cord-028721-x6f26ahr 3763 4 , , , cord-028721-x6f26ahr 3763 5 there there EX cord-028721-x6f26ahr 3763 6 is be VBZ cord-028721-x6f26ahr 3763 7 a a DT cord-028721-x6f26ahr 3763 8 small small JJ cord-028721-x6f26ahr 3763 9 nodule nodule NN cord-028721-x6f26ahr 3763 10 that that WDT cord-028721-x6f26ahr 3763 11 corresponds correspond VBZ cord-028721-x6f26ahr 3763 12 to to IN cord-028721-x6f26ahr 3763 13 remnants remnant NNS cord-028721-x6f26ahr 3763 14 of of IN cord-028721-x6f26ahr 3763 15 the the DT cord-028721-x6f26ahr 3763 16 twisted twisted JJ cord-028721-x6f26ahr 3763 17 testis testis NN cord-028721-x6f26ahr 3763 18 . . . cord-028721-x6f26ahr 3764 1 The the DT cord-028721-x6f26ahr 3764 2 epididymis epididymis NN cord-028721-x6f26ahr 3764 3 and and CC cord-028721-x6f26ahr 3764 4 proximal proximal JJ cord-028721-x6f26ahr 3764 5 spermatic spermatic JJ cord-028721-x6f26ahr 3764 6 cord cord NN cord-028721-x6f26ahr 3764 7 characteristically characteristically RB cord-028721-x6f26ahr 3764 8 contain contain VBP cord-028721-x6f26ahr 3764 9 fat fat JJ cord-028721-x6f26ahr 3764 10 necrosis necrosis NN cord-028721-x6f26ahr 3765 1 ( ( -LRB- cord-028721-x6f26ahr 3765 2 Fig Fig NNP cord-028721-x6f26ahr 3765 3 . . . cord-028721-x6f26ahr 3765 4 12 12 CD cord-028721-x6f26ahr 3765 5 - - SYM cord-028721-x6f26ahr 3765 6 167 167 CD cord-028721-x6f26ahr 3765 7 ) ) -RRB- cord-028721-x6f26ahr 3765 8 . . . cord-028721-x6f26ahr 3766 1 Adults adult NNS cord-028721-x6f26ahr 3766 2 with with IN cord-028721-x6f26ahr 3766 3 prior prior JJ cord-028721-x6f26ahr 3766 4 spermatic spermatic JJ cord-028721-x6f26ahr 3766 5 cord cord NN cord-028721-x6f26ahr 3766 6 torsion torsion NN cord-028721-x6f26ahr 3766 7 often often RB cord-028721-x6f26ahr 3766 8 consult consult VBP cord-028721-x6f26ahr 3766 9 for for IN cord-028721-x6f26ahr 3766 10 infertility infertility NN cord-028721-x6f26ahr 3766 11 . . . cord-028721-x6f26ahr 3767 1 The the DT cord-028721-x6f26ahr 3767 2 mechanism mechanism NN cord-028721-x6f26ahr 3767 3 causing cause VBG cord-028721-x6f26ahr 3767 4 spermiogram spermiogram NNP cord-028721-x6f26ahr 3767 5 alteration alteration NN cord-028721-x6f26ahr 3767 6 is be VBZ cord-028721-x6f26ahr 3767 7 controversial controversial JJ cord-028721-x6f26ahr 3767 8 , , , cord-028721-x6f26ahr 3767 9 and and CC cord-028721-x6f26ahr 3767 10 three three CD cord-028721-x6f26ahr 3767 11 hypotheses hypothesis NNS cord-028721-x6f26ahr 3767 12 have have VBP cord-028721-x6f26ahr 3767 13 been be VBN cord-028721-x6f26ahr 3767 14 proposed propose VBN cord-028721-x6f26ahr 3767 15 : : : cord-028721-x6f26ahr 3767 16 • • NNP cord-028721-x6f26ahr 3767 17 Autoimmune Autoimmune NNP cord-028721-x6f26ahr 3767 18 process process NN cord-028721-x6f26ahr 3767 19 . . . cord-028721-x6f26ahr 3768 1 It -PRON- PRP cord-028721-x6f26ahr 3768 2 has have VBZ cord-028721-x6f26ahr 3768 3 been be VBN cord-028721-x6f26ahr 3768 4 suggested suggest VBN cord-028721-x6f26ahr 3768 5 that that IN cord-028721-x6f26ahr 3768 6 the the DT cord-028721-x6f26ahr 3768 7 ischemic ischemic JJ cord-028721-x6f26ahr 3768 8 injury injury NN cord-028721-x6f26ahr 3768 9 breaks break VBZ cord-028721-x6f26ahr 3768 10 the the DT cord-028721-x6f26ahr 3768 11 blood blood NN cord-028721-x6f26ahr 3768 12 - - HYPH cord-028721-x6f26ahr 3768 13 testis testis NN cord-028721-x6f26ahr 3768 14 barrier barrier NN cord-028721-x6f26ahr 3768 15 , , , cord-028721-x6f26ahr 3768 16 and and CC cord-028721-x6f26ahr 3768 17 antigens antigen NNS cord-028721-x6f26ahr 3768 18 released release VBN cord-028721-x6f26ahr 3768 19 from from IN cord-028721-x6f26ahr 3768 20 the the DT cord-028721-x6f26ahr 3768 21 necrotic necrotic JJ cord-028721-x6f26ahr 3768 22 germ germ NN cord-028721-x6f26ahr 3768 23 cells cell NNS cord-028721-x6f26ahr 3768 24 activate activate VBP cord-028721-x6f26ahr 3768 25 macrophages macrophage NNS cord-028721-x6f26ahr 3768 26 and and CC cord-028721-x6f26ahr 3768 27 lymphocytes lymphocyte NNS cord-028721-x6f26ahr 3768 28 in in IN cord-028721-x6f26ahr 3768 29 the the DT cord-028721-x6f26ahr 3768 30 interstitium interstitium NN cord-028721-x6f26ahr 3768 31 , , , cord-028721-x6f26ahr 3768 32 stimulating stimulate VBG cord-028721-x6f26ahr 3768 33 the the DT cord-028721-x6f26ahr 3768 34 formation formation NN cord-028721-x6f26ahr 3768 35 of of IN cord-028721-x6f26ahr 3768 36 antibodies antibody NNS cord-028721-x6f26ahr 3768 37 against against IN cord-028721-x6f26ahr 3768 38 these these DT cord-028721-x6f26ahr 3768 39 antigens antigen NNS cord-028721-x6f26ahr 3768 40 . . . cord-028721-x6f26ahr 3769 1 These these DT cord-028721-x6f26ahr 3769 2 antibodies antibody NNS cord-028721-x6f26ahr 3769 3 that that WDT cord-028721-x6f26ahr 3769 4 enter enter VBP cord-028721-x6f26ahr 3769 5 in in IN cord-028721-x6f26ahr 3769 6 the the DT cord-028721-x6f26ahr 3769 7 blood blood NN cord-028721-x6f26ahr 3769 8 circulation circulation NN cord-028721-x6f26ahr 3769 9 may may MD cord-028721-x6f26ahr 3769 10 presumably presumably RB cord-028721-x6f26ahr 3769 11 damage damage VB cord-028721-x6f26ahr 3769 12 the the DT cord-028721-x6f26ahr 3769 13 contralateral contralateral JJ cord-028721-x6f26ahr 3769 14 testis testis NN cord-028721-x6f26ahr 3769 15 . . . cord-028721-x6f26ahr 3770 1 1595 1595 CD cord-028721-x6f26ahr 3771 1 • • NNP cord-028721-x6f26ahr 3772 1 Alterations alteration NNS cord-028721-x6f26ahr 3772 2 in in IN cord-028721-x6f26ahr 3772 3 microcirculation microcirculation NN cord-028721-x6f26ahr 3772 4 . . . cord-028721-x6f26ahr 3773 1 After after IN cord-028721-x6f26ahr 3773 2 testicular testicular JJ cord-028721-x6f26ahr 3773 3 torsion torsion NN cord-028721-x6f26ahr 3773 4 , , , cord-028721-x6f26ahr 3773 5 blood blood NN cord-028721-x6f26ahr 3773 6 fl fl NNP cord-028721-x6f26ahr 3773 7 ow ow NNP cord-028721-x6f26ahr 3773 8 decreases decrease VBZ cord-028721-x6f26ahr 3773 9 in in IN cord-028721-x6f26ahr 3773 10 the the DT cord-028721-x6f26ahr 3773 11 contralateral contralateral JJ cord-028721-x6f26ahr 3773 12 testis testis NN cord-028721-x6f26ahr 3773 13 , , , cord-028721-x6f26ahr 3773 14 causing cause VBG cord-028721-x6f26ahr 3773 15 an an DT cord-028721-x6f26ahr 3773 16 increase increase NN cord-028721-x6f26ahr 3773 17 in in IN cord-028721-x6f26ahr 3773 18 the the DT cord-028721-x6f26ahr 3773 19 characteristic characteristic JJ cord-028721-x6f26ahr 3773 20 products product NNS cord-028721-x6f26ahr 3773 21 of of IN cord-028721-x6f26ahr 3773 22 hypoxia hypoxia NN cord-028721-x6f26ahr 3773 23 , , , cord-028721-x6f26ahr 3773 24 such such JJ cord-028721-x6f26ahr 3773 25 as as IN cord-028721-x6f26ahr 3773 26 lactic lactic JJ cord-028721-x6f26ahr 3773 27 acid acid NN cord-028721-x6f26ahr 3773 28 and and CC cord-028721-x6f26ahr 3773 29 hypoxanthine hypoxanthine NN cord-028721-x6f26ahr 3773 30 . . . cord-028721-x6f26ahr 3774 1 1596 1596 CD cord-028721-x6f26ahr 3775 1 Intense intense JJ cord-028721-x6f26ahr 3775 2 apoptosis apoptosis NN cord-028721-x6f26ahr 3775 3 involving involve VBG cord-028721-x6f26ahr 3775 4 mainly mainly RB cord-028721-x6f26ahr 3775 5 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 3776 1 I -PRON- PRP cord-028721-x6f26ahr 3776 2 and and CC cord-028721-x6f26ahr 3776 3 II II NNP cord-028721-x6f26ahr 3776 4 has have VBZ cord-028721-x6f26ahr 3776 5 been be VBN cord-028721-x6f26ahr 3776 6 observed observe VBN cord-028721-x6f26ahr 3776 7 . . . cord-028721-x6f26ahr 3777 1 1597 1597 CD cord-028721-x6f26ahr 3777 2 Long long JJ cord-028721-x6f26ahr 3777 3 - - HYPH cord-028721-x6f26ahr 3777 4 term term NN cord-028721-x6f26ahr 3777 5 effects effect NNS cord-028721-x6f26ahr 3777 6 are be VBP cord-028721-x6f26ahr 3777 7 yet yet RB cord-028721-x6f26ahr 3777 8 unknown unknown JJ cord-028721-x6f26ahr 3777 9 . . . cord-028721-x6f26ahr 3778 1 • • NNP cord-028721-x6f26ahr 3779 1 Primary primary JJ cord-028721-x6f26ahr 3779 2 testicular testicular JJ cord-028721-x6f26ahr 3779 3 lesions lesion NNS cord-028721-x6f26ahr 3779 4 . . . cord-028721-x6f26ahr 3780 1 Many many JJ cord-028721-x6f26ahr 3780 2 twisted twisted JJ cord-028721-x6f26ahr 3780 3 testes testis NNS cord-028721-x6f26ahr 3780 4 have have VBP cord-028721-x6f26ahr 3780 5 lesions lesion NNS cord-028721-x6f26ahr 3780 6 that that WDT cord-028721-x6f26ahr 3780 7 can can MD cord-028721-x6f26ahr 3780 8 not not RB cord-028721-x6f26ahr 3780 9 be be VB cord-028721-x6f26ahr 3780 10 formed form VBN cord-028721-x6f26ahr 3780 11 in in IN cord-028721-x6f26ahr 3780 12 a a DT cord-028721-x6f26ahr 3780 13 few few JJ cord-028721-x6f26ahr 3780 14 hours hour NNS cord-028721-x6f26ahr 3780 15 , , , cord-028721-x6f26ahr 3780 16 such such JJ cord-028721-x6f26ahr 3780 17 as as IN cord-028721-x6f26ahr 3780 18 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 3780 19 tubules tubule NNS cord-028721-x6f26ahr 3780 20 , , , cord-028721-x6f26ahr 3780 21 microlithiasis microlithiasis NN cord-028721-x6f26ahr 3780 22 , , , cord-028721-x6f26ahr 3780 23 and and CC cord-028721-x6f26ahr 3780 24 focal focal JJ cord-028721-x6f26ahr 3780 25 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3780 26 . . . cord-028721-x6f26ahr 3781 1 In in IN cord-028721-x6f26ahr 3781 2 addition addition NN cord-028721-x6f26ahr 3781 3 , , , cord-028721-x6f26ahr 3781 4 more more JJR cord-028721-x6f26ahr 3781 5 than than IN cord-028721-x6f26ahr 3781 6 half half NN cord-028721-x6f26ahr 3781 7 of of IN cord-028721-x6f26ahr 3781 8 biopsies biopsy NNS cord-028721-x6f26ahr 3781 9 of of IN cord-028721-x6f26ahr 3781 10 the the DT cord-028721-x6f26ahr 3781 11 contralateral contralateral JJ cord-028721-x6f26ahr 3781 12 testis testis NN cord-028721-x6f26ahr 3781 13 show show NN cord-028721-x6f26ahr 3781 14 marked mark VBD cord-028721-x6f26ahr 3781 15 spermatogenetic spermatogenetic NN cord-028721-x6f26ahr 3781 16 lesions lesion NNS cord-028721-x6f26ahr 3781 17 . . . cord-028721-x6f26ahr 3782 1 1598 1598 CD cord-028721-x6f26ahr 3783 1 These these DT cord-028721-x6f26ahr 3783 2 fi fi NN cord-028721-x6f26ahr 3783 3 ndings nding NNS cord-028721-x6f26ahr 3783 4 suggest suggest VBP cord-028721-x6f26ahr 3783 5 that that IN cord-028721-x6f26ahr 3783 6 torsion torsion NN cord-028721-x6f26ahr 3783 7 occurs occur VBZ cord-028721-x6f26ahr 3783 8 in in IN cord-028721-x6f26ahr 3783 9 testes testis NNS cord-028721-x6f26ahr 3783 10 with with IN cord-028721-x6f26ahr 3783 11 congenital congenital JJ cord-028721-x6f26ahr 3783 12 lesions lesion NNS cord-028721-x6f26ahr 3783 13 . . . cord-028721-x6f26ahr 3784 1 Trauma trauma NN cord-028721-x6f26ahr 3784 2 1599 1599 CD cord-028721-x6f26ahr 3784 3 and and CC cord-028721-x6f26ahr 3784 4 lesions lesion NNS cord-028721-x6f26ahr 3784 5 of of IN cord-028721-x6f26ahr 3784 6 the the DT cord-028721-x6f26ahr 3784 7 vessels vessel NNS cord-028721-x6f26ahr 3784 8 of of IN cord-028721-x6f26ahr 3784 9 the the DT cord-028721-x6f26ahr 3784 10 spermatic spermatic JJ cord-028721-x6f26ahr 3784 11 cord cord NN cord-028721-x6f26ahr 3784 12 may may MD cord-028721-x6f26ahr 3784 13 also also RB cord-028721-x6f26ahr 3784 14 cause cause VB cord-028721-x6f26ahr 3784 15 testicular testicular JJ cord-028721-x6f26ahr 3784 16 infarct infarct NN cord-028721-x6f26ahr 3784 17 . . . cord-028721-x6f26ahr 3785 1 Ischemic ischemic JJ cord-028721-x6f26ahr 3785 2 atrophy atrophy NN cord-028721-x6f26ahr 3785 3 is be VBZ cord-028721-x6f26ahr 3785 4 a a DT cord-028721-x6f26ahr 3785 5 risk risk NN cord-028721-x6f26ahr 3785 6 of of IN cord-028721-x6f26ahr 3785 7 inguinal inguinal JJ cord-028721-x6f26ahr 3785 8 surgery surgery NN cord-028721-x6f26ahr 3785 9 , , , cord-028721-x6f26ahr 3785 10 including include VBG cord-028721-x6f26ahr 3785 11 herniorrhaphy herniorrhaphy NN cord-028721-x6f26ahr 3785 12 , , , cord-028721-x6f26ahr 3785 13 varicocelectomy varicocelectomy NNP cord-028721-x6f26ahr 3785 14 , , , cord-028721-x6f26ahr 3785 15 hydrocelectomy hydrocelectomy NN cord-028721-x6f26ahr 3785 16 , , , cord-028721-x6f26ahr 3785 17 and and CC cord-028721-x6f26ahr 3785 18 descent descent NN cord-028721-x6f26ahr 3785 19 of of IN cord-028721-x6f26ahr 3785 20 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3785 21 testis testis NN cord-028721-x6f26ahr 3785 22 ( ( -LRB- cord-028721-x6f26ahr 3785 23 Fig Fig NNP cord-028721-x6f26ahr 3785 24 . . . cord-028721-x6f26ahr 3785 25 12 12 CD cord-028721-x6f26ahr 3785 26 - - SYM cord-028721-x6f26ahr 3785 27 168 168 CD cord-028721-x6f26ahr 3785 28 ) ) -RRB- cord-028721-x6f26ahr 3785 29 . . . cord-028721-x6f26ahr 3786 1 The the DT cord-028721-x6f26ahr 3786 2 incidence incidence NN cord-028721-x6f26ahr 3786 3 of of IN cord-028721-x6f26ahr 3786 4 atrophy atrophy NN cord-028721-x6f26ahr 3786 5 after after IN cord-028721-x6f26ahr 3786 6 inguinal inguinal JJ cord-028721-x6f26ahr 3786 7 herniorrhaphy herniorrhaphy NN cord-028721-x6f26ahr 3786 8 varies vary VBZ cord-028721-x6f26ahr 3786 9 from from IN cord-028721-x6f26ahr 3786 10 0.06 0.06 CD cord-028721-x6f26ahr 3786 11 % % NN cord-028721-x6f26ahr 3786 12 in in IN cord-028721-x6f26ahr 3786 13 primary primary JJ cord-028721-x6f26ahr 3786 14 herniorrhaphy herniorrhaphy NN cord-028721-x6f26ahr 3786 15 1600 1600 CD cord-028721-x6f26ahr 3786 16 to to IN cord-028721-x6f26ahr 3786 17 7.9 7.9 CD cord-028721-x6f26ahr 3786 18 % % NN cord-028721-x6f26ahr 3786 19 after after IN cord-028721-x6f26ahr 3786 20 surgery surgery NN cord-028721-x6f26ahr 3786 21 for for IN cord-028721-x6f26ahr 3786 22 recurrent recurrent JJ cord-028721-x6f26ahr 3786 23 herna herna NN cord-028721-x6f26ahr 3786 24 , , , cord-028721-x6f26ahr 3786 25 1601 1601 CD cord-028721-x6f26ahr 3786 26 depending depend VBG cord-028721-x6f26ahr 3786 27 on on IN cord-028721-x6f26ahr 3786 28 the the DT cord-028721-x6f26ahr 3786 29 diffi diffi NNP cord-028721-x6f26ahr 3786 30 culty culty NNP cord-028721-x6f26ahr 3786 31 and and CC cord-028721-x6f26ahr 3786 32 extent extent NN cord-028721-x6f26ahr 3786 33 of of IN cord-028721-x6f26ahr 3786 34 the the DT cord-028721-x6f26ahr 3786 35 hernia hernia NN cord-028721-x6f26ahr 3786 36 . . . cord-028721-x6f26ahr 3787 1 Atrophy atrophy NN cord-028721-x6f26ahr 3787 2 occurs occur VBZ cord-028721-x6f26ahr 3787 3 in in IN cord-028721-x6f26ahr 3787 4 some some DT cord-028721-x6f26ahr 3787 5 cases case NNS cord-028721-x6f26ahr 3787 6 of of IN cord-028721-x6f26ahr 3787 7 thrombosis thrombosis NN cord-028721-x6f26ahr 3787 8 of of IN cord-028721-x6f26ahr 3787 9 the the DT cord-028721-x6f26ahr 3787 10 vena vena NNP cord-028721-x6f26ahr 3787 11 cava cava NNP cord-028721-x6f26ahr 3787 12 or or CC cord-028721-x6f26ahr 3787 13 spermatic spermatic JJ cord-028721-x6f26ahr 3787 14 artery artery NN cord-028721-x6f26ahr 3787 15 . . . cord-028721-x6f26ahr 3788 1 1602 1602 CD cord-028721-x6f26ahr 3788 2 Focal focal JJ cord-028721-x6f26ahr 3788 3 infarction infarction NN cord-028721-x6f26ahr 3788 4 of of IN cord-028721-x6f26ahr 3788 5 the the DT cord-028721-x6f26ahr 3788 6 testis testis NN cord-028721-x6f26ahr 3788 7 is be VBZ cord-028721-x6f26ahr 3788 8 associated associate VBN cord-028721-x6f26ahr 3788 9 with with IN cord-028721-x6f26ahr 3788 10 polycythemia polycythemia NN cord-028721-x6f26ahr 3788 11 , , , cord-028721-x6f26ahr 3788 12 sickle sickle NN cord-028721-x6f26ahr 3788 13 cell cell NN cord-028721-x6f26ahr 3788 14 disease disease NN cord-028721-x6f26ahr 3788 15 , , , cord-028721-x6f26ahr 3788 16 trauma trauma NN cord-028721-x6f26ahr 3788 17 , , , cord-028721-x6f26ahr 3788 18 1603 1603 CD cord-028721-x6f26ahr 3788 19 , , , cord-028721-x6f26ahr 3788 20 1604 1604 CD cord-028721-x6f26ahr 3788 21 and and CC cord-028721-x6f26ahr 3788 22 laparoscopic laparoscopic JJ cord-028721-x6f26ahr 3788 23 inguinal inguinal JJ cord-028721-x6f26ahr 3788 24 hernia hernia NN cord-028721-x6f26ahr 3788 25 repair repair NN cord-028721-x6f26ahr 3788 26 . . . cord-028721-x6f26ahr 3789 1 Focal focal JJ cord-028721-x6f26ahr 3789 2 infarction infarction NN cord-028721-x6f26ahr 3789 3 may may MD cord-028721-x6f26ahr 3789 4 also also RB cord-028721-x6f26ahr 3789 5 be be VB cord-028721-x6f26ahr 3789 6 spontaneous spontaneous JJ cord-028721-x6f26ahr 3789 7 . . . cord-028721-x6f26ahr 3790 1 Clinical clinical JJ cord-028721-x6f26ahr 3790 2 symptoms symptom NNS cord-028721-x6f26ahr 3790 3 of of IN cord-028721-x6f26ahr 3790 4 testicular testicular NN cord-028721-x6f26ahr 3790 5 infarct infarct NN cord-028721-x6f26ahr 3790 6 mimic mimic VBP cord-028721-x6f26ahr 3790 7 testicular testicular JJ cord-028721-x6f26ahr 3790 8 tumor tumor NN cord-028721-x6f26ahr 3790 9 . . . cord-028721-x6f26ahr 3791 1 Color Color NNP cord-028721-x6f26ahr 3791 2 Doppler Doppler NNP cord-028721-x6f26ahr 3791 3 ultrasound ultrasound NN cord-028721-x6f26ahr 3791 4 reveals reveal VBZ cord-028721-x6f26ahr 3791 5 the the DT cord-028721-x6f26ahr 3791 6 diagnosis diagnosis NN cord-028721-x6f26ahr 3791 7 in in IN cord-028721-x6f26ahr 3791 8 most most JJS cord-028721-x6f26ahr 3791 9 cases case NNS cord-028721-x6f26ahr 3791 10 . . . cord-028721-x6f26ahr 3792 1 1605 1605 CD cord-028721-x6f26ahr 3792 2 Cystic cystic JJ cord-028721-x6f26ahr 3792 3 malformation malformation NN cord-028721-x6f26ahr 3792 4 of of IN cord-028721-x6f26ahr 3792 5 the the DT cord-028721-x6f26ahr 3792 6 tunica tunica NNP cord-028721-x6f26ahr 3792 7 albuginea albuginea NNP cord-028721-x6f26ahr 3792 8 and and CC cord-028721-x6f26ahr 3792 9 testicular testicular JJ cord-028721-x6f26ahr 3792 10 parenchyma parenchyma NN cord-028721-x6f26ahr 3792 11 was be VBD cord-028721-x6f26ahr 3792 12 fi fi NNP cord-028721-x6f26ahr 3792 13 rst rst NNP cord-028721-x6f26ahr 3792 14 described describe VBN cord-028721-x6f26ahr 3792 15 in in IN cord-028721-x6f26ahr 3792 16 the the DT cord-028721-x6f26ahr 3792 17 19th 19th JJ cord-028721-x6f26ahr 3792 18 century century NN cord-028721-x6f26ahr 3792 19 , , , cord-028721-x6f26ahr 3792 20 1606 1606 CD cord-028721-x6f26ahr 3792 21 and and CC cord-028721-x6f26ahr 3792 22 was be VBD cord-028721-x6f26ahr 3792 23 long long RB cord-028721-x6f26ahr 3792 24 considered consider VBN cord-028721-x6f26ahr 3792 25 rare rare JJ cord-028721-x6f26ahr 3792 26 and and CC cord-028721-x6f26ahr 3792 27 mainly mainly RB cord-028721-x6f26ahr 3792 28 present present JJ cord-028721-x6f26ahr 3792 29 in in IN cord-028721-x6f26ahr 3792 30 the the DT cord-028721-x6f26ahr 3792 31 tunica tunica NNP cord-028721-x6f26ahr 3792 32 albuginea albuginea NNP cord-028721-x6f26ahr 3792 33 . . . cord-028721-x6f26ahr 3793 1 1607 1607 CD cord-028721-x6f26ahr 3793 2 , , , cord-028721-x6f26ahr 3793 3 1608 1608 CD cord-028721-x6f26ahr 3794 1 With with IN cord-028721-x6f26ahr 3794 2 the the DT cord-028721-x6f26ahr 3794 3 systematic systematic JJ cord-028721-x6f26ahr 3794 4 use use NN cord-028721-x6f26ahr 3794 5 of of IN cord-028721-x6f26ahr 3794 6 ultrasonography ultrasonography NN cord-028721-x6f26ahr 3794 7 , , , cord-028721-x6f26ahr 3794 8 the the DT cord-028721-x6f26ahr 3794 9 incidence incidence NN cord-028721-x6f26ahr 3794 10 of of IN cord-028721-x6f26ahr 3794 11 cysts cyst NNS cord-028721-x6f26ahr 3794 12 has have VBZ cord-028721-x6f26ahr 3794 13 been be VBN cord-028721-x6f26ahr 3794 14 found find VBN cord-028721-x6f26ahr 3794 15 to to TO cord-028721-x6f26ahr 3794 16 be be VB cord-028721-x6f26ahr 3794 17 much much RB cord-028721-x6f26ahr 3794 18 higher high JJR cord-028721-x6f26ahr 3794 19 : : : cord-028721-x6f26ahr 3794 20 1609 1609 CD cord-028721-x6f26ahr 3794 21 non non JJ cord-028721-x6f26ahr 3794 22 - - JJ cord-028721-x6f26ahr 3794 23 neoplastic neoplastic JJ cord-028721-x6f26ahr 3794 24 cysts cyst NNS cord-028721-x6f26ahr 3794 25 are be VBP cord-028721-x6f26ahr 3794 26 found find VBN cord-028721-x6f26ahr 3794 27 in in IN cord-028721-x6f26ahr 3794 28 2.1 2.1 CD cord-028721-x6f26ahr 3794 29 % % NN cord-028721-x6f26ahr 3794 30 1610 1610 CD cord-028721-x6f26ahr 3794 31 to to TO cord-028721-x6f26ahr 3794 32 9.8 9.8 CD cord-028721-x6f26ahr 3794 33 % % NN cord-028721-x6f26ahr 3794 34 1611 1611 CD cord-028721-x6f26ahr 3794 35 of of IN cord-028721-x6f26ahr 3794 36 testes testis NNS cord-028721-x6f26ahr 3794 37 . . . cord-028721-x6f26ahr 3795 1 1612 1612 CD cord-028721-x6f26ahr 3795 2 , , , cord-028721-x6f26ahr 3795 3 1613 1613 CD cord-028721-x6f26ahr 3795 4 Cyst Cyst NNP cord-028721-x6f26ahr 3795 5 of of IN cord-028721-x6f26ahr 3795 6 the the DT cord-028721-x6f26ahr 3795 7 tunica tunica NNP cord-028721-x6f26ahr 3795 8 albuginea albuginea NNP cord-028721-x6f26ahr 3795 9 is be VBZ cord-028721-x6f26ahr 3795 10 usually usually RB cord-028721-x6f26ahr 3795 11 an an DT cord-028721-x6f26ahr 3795 12 incidental incidental JJ cord-028721-x6f26ahr 3795 13 fi fi NN cord-028721-x6f26ahr 3795 14 nding nding NN cord-028721-x6f26ahr 3795 15 in in IN cord-028721-x6f26ahr 3795 16 patients patient NNS cord-028721-x6f26ahr 3795 17 in in IN cord-028721-x6f26ahr 3795 18 the the DT cord-028721-x6f26ahr 3795 19 fi fi NN cord-028721-x6f26ahr 3795 20 fth fth NN cord-028721-x6f26ahr 3795 21 or or CC cord-028721-x6f26ahr 3795 22 sixth sixth JJ cord-028721-x6f26ahr 3795 23 decade decade NN cord-028721-x6f26ahr 3795 24 of of IN cord-028721-x6f26ahr 3795 25 life life NN cord-028721-x6f26ahr 3795 26 . . . cord-028721-x6f26ahr 3796 1 It -PRON- PRP cord-028721-x6f26ahr 3796 2 is be VBZ cord-028721-x6f26ahr 3796 3 located locate VBN cord-028721-x6f26ahr 3796 4 in in IN cord-028721-x6f26ahr 3796 5 the the DT cord-028721-x6f26ahr 3796 6 anterolateral anterolateral JJ cord-028721-x6f26ahr 3796 7 aspect aspect NN cord-028721-x6f26ahr 3796 8 of of IN cord-028721-x6f26ahr 3796 9 the the DT cord-028721-x6f26ahr 3796 10 testis testis NN cord-028721-x6f26ahr 3796 11 and and CC cord-028721-x6f26ahr 3796 12 may may MD cord-028721-x6f26ahr 3796 13 be be VB cord-028721-x6f26ahr 3796 14 unilocular unilocular NNP cord-028721-x6f26ahr 3796 15 or or CC cord-028721-x6f26ahr 3796 16 multilocular multilocular NNP cord-028721-x6f26ahr 3796 17 , , , cord-028721-x6f26ahr 3796 18 1614 1614 CD cord-028721-x6f26ahr 3796 19 ranging range VBG cord-028721-x6f26ahr 3796 20 from from IN cord-028721-x6f26ahr 3796 21 2 2 CD cord-028721-x6f26ahr 3796 22 to to IN cord-028721-x6f26ahr 3796 23 4 4 CD cord-028721-x6f26ahr 3796 24 mm mm NNS cord-028721-x6f26ahr 3796 25 and and CC cord-028721-x6f26ahr 3796 26 containing contain VBG cord-028721-x6f26ahr 3796 27 clear clear JJ cord-028721-x6f26ahr 3796 28 fl fl NNP cord-028721-x6f26ahr 3796 29 uid uid NN cord-028721-x6f26ahr 3796 30 without without IN cord-028721-x6f26ahr 3796 31 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3796 32 . . . cord-028721-x6f26ahr 3797 1 The the DT cord-028721-x6f26ahr 3797 2 cyst cyst NN cord-028721-x6f26ahr 3797 3 may may MD cord-028721-x6f26ahr 3797 4 be be VB cord-028721-x6f26ahr 3797 5 embedded embed VBN cord-028721-x6f26ahr 3797 6 within within IN cord-028721-x6f26ahr 3797 7 the the DT cord-028721-x6f26ahr 3797 8 connective connective JJ cord-028721-x6f26ahr 3797 9 tissue tissue NN cord-028721-x6f26ahr 3797 10 of of IN cord-028721-x6f26ahr 3797 11 the the DT cord-028721-x6f26ahr 3797 12 tunica tunica NNP cord-028721-x6f26ahr 3797 13 albuginea albuginea NNP cord-028721-x6f26ahr 3797 14 , , , cord-028721-x6f26ahr 3797 15 protrude protrude VBP cord-028721-x6f26ahr 3797 16 from from IN cord-028721-x6f26ahr 3797 17 the the DT cord-028721-x6f26ahr 3797 18 inner inner JJ cord-028721-x6f26ahr 3797 19 surface surface NN cord-028721-x6f26ahr 3797 20 of of IN cord-028721-x6f26ahr 3797 21 the the DT cord-028721-x6f26ahr 3797 22 tunica tunica NNP cord-028721-x6f26ahr 3797 23 albuginea albuginea NNP cord-028721-x6f26ahr 3797 24 into into IN cord-028721-x6f26ahr 3797 25 the the DT cord-028721-x6f26ahr 3797 26 testicular testicular JJ cord-028721-x6f26ahr 3797 27 parenchyma parenchyma NN cord-028721-x6f26ahr 3797 28 , , , cord-028721-x6f26ahr 3797 29 or or CC cord-028721-x6f26ahr 3797 30 protrude protrude VB cord-028721-x6f26ahr 3797 31 from from IN cord-028721-x6f26ahr 3797 32 the the DT cord-028721-x6f26ahr 3797 33 outer outer JJ cord-028721-x6f26ahr 3797 34 surface surface NN cord-028721-x6f26ahr 3797 35 forming form VBG cord-028721-x6f26ahr 3797 36 a a DT cord-028721-x6f26ahr 3797 37 blue blue JJ cord-028721-x6f26ahr 3797 38 lump lump NN cord-028721-x6f26ahr 3797 39 in in IN cord-028721-x6f26ahr 3797 40 the the DT cord-028721-x6f26ahr 3797 41 tunica tunica NNP cord-028721-x6f26ahr 3797 42 albuginea albuginea NNP cord-028721-x6f26ahr 3797 43 . . . cord-028721-x6f26ahr 3798 1 The the DT cord-028721-x6f26ahr 3798 2 epithelium epithelium NN cord-028721-x6f26ahr 3798 3 lining line VBG cord-028721-x6f26ahr 3798 4 the the DT cord-028721-x6f26ahr 3798 5 cyst cyst NN cord-028721-x6f26ahr 3798 6 may may MD cord-028721-x6f26ahr 3798 7 be be VB cord-028721-x6f26ahr 3798 8 simple simple JJ cord-028721-x6f26ahr 3798 9 columnar columnar JJ cord-028721-x6f26ahr 3798 10 or or CC cord-028721-x6f26ahr 3798 11 stratifi stratifi NNP cord-028721-x6f26ahr 3798 12 ed ed NNP cord-028721-x6f26ahr 3798 13 cuboidal cuboidal JJ cord-028721-x6f26ahr 3798 14 , , , cord-028721-x6f26ahr 3798 15 and and CC cord-028721-x6f26ahr 3798 16 is be VBZ cord-028721-x6f26ahr 3798 17 supported support VBN cord-028721-x6f26ahr 3798 18 by by IN cord-028721-x6f26ahr 3798 19 a a DT cord-028721-x6f26ahr 3798 20 thin thin JJ cord-028721-x6f26ahr 3798 21 layer layer NN cord-028721-x6f26ahr 3798 22 of of IN cord-028721-x6f26ahr 3798 23 collagenized collagenized JJ cord-028721-x6f26ahr 3798 24 connective connective JJ cord-028721-x6f26ahr 3798 25 tissue tissue NN cord-028721-x6f26ahr 3798 26 . . . cord-028721-x6f26ahr 3799 1 The the DT cord-028721-x6f26ahr 3799 2 columnar columnar JJ cord-028721-x6f26ahr 3799 3 epithelium epithelium NN cord-028721-x6f26ahr 3799 4 usually usually RB cord-028721-x6f26ahr 3799 5 includes include VBZ cord-028721-x6f26ahr 3799 6 some some DT cord-028721-x6f26ahr 3799 7 ciliated ciliated JJ cord-028721-x6f26ahr 3799 8 cells cell NNS cord-028721-x6f26ahr 3799 9 , , , cord-028721-x6f26ahr 3799 10 1615 1615 CD cord-028721-x6f26ahr 3799 11 and and CC cord-028721-x6f26ahr 3799 12 the the DT cord-028721-x6f26ahr 3799 13 cuboidal cuboidal JJ cord-028721-x6f26ahr 3799 14 epithelium epithelium NN cord-028721-x6f26ahr 3799 15 is be VBZ cord-028721-x6f26ahr 3799 16 composed compose VBN cord-028721-x6f26ahr 3799 17 of of IN cord-028721-x6f26ahr 3799 18 two two CD cord-028721-x6f26ahr 3799 19 layers layer NNS cord-028721-x6f26ahr 3799 20 of of IN cord-028721-x6f26ahr 3799 21 non non JJ cord-028721-x6f26ahr 3799 22 - - JJ cord-028721-x6f26ahr 3799 23 ciliated ciliated JJ cord-028721-x6f26ahr 3799 24 cells cell NNS cord-028721-x6f26ahr 3799 25 ( ( -LRB- cord-028721-x6f26ahr 3799 26 Fig fig NN cord-028721-x6f26ahr 3799 27 . . . cord-028721-x6f26ahr 3799 28 _SP cord-028721-x6f26ahr 3800 1 12 12 CD cord-028721-x6f26ahr 3800 2 - - SYM cord-028721-x6f26ahr 3800 3 169 169 CD cord-028721-x6f26ahr 3800 4 ) ) -RRB- cord-028721-x6f26ahr 3800 5 . . . cord-028721-x6f26ahr 3801 1 Cyst Cyst NNP cord-028721-x6f26ahr 3801 2 of of IN cord-028721-x6f26ahr 3801 3 the the DT cord-028721-x6f26ahr 3801 4 rete rete NNP cord-028721-x6f26ahr 3801 5 testis testis NN cord-028721-x6f26ahr 3801 6 is be VBZ cord-028721-x6f26ahr 3801 7 identifi identifi NNP cord-028721-x6f26ahr 3801 8 ed ed NNP cord-028721-x6f26ahr 3801 9 by by IN cord-028721-x6f26ahr 3801 10 a a DT cord-028721-x6f26ahr 3801 11 distinctive distinctive JJ cord-028721-x6f26ahr 3801 12 epithelial epithelial JJ cord-028721-x6f26ahr 3801 13 lining lining NN cord-028721-x6f26ahr 3801 14 of of IN cord-028721-x6f26ahr 3801 15 areas area NNS cord-028721-x6f26ahr 3801 16 of of IN cord-028721-x6f26ahr 3801 17 fl fl NNP cord-028721-x6f26ahr 3801 18 attened attene VBN cord-028721-x6f26ahr 3801 19 cells cell NNS cord-028721-x6f26ahr 3801 20 intermingled intermingle VBN cord-028721-x6f26ahr 3801 21 with with IN cord-028721-x6f26ahr 3801 22 areas area NNS cord-028721-x6f26ahr 3801 23 of of IN cord-028721-x6f26ahr 3801 24 tall tall JJ cord-028721-x6f26ahr 3801 25 columnar columnar JJ cord-028721-x6f26ahr 3801 26 cells cell NNS cord-028721-x6f26ahr 3801 27 . . . cord-028721-x6f26ahr 3802 1 Spermatozoa spermatozoon NNS cord-028721-x6f26ahr 3802 2 are be VBP cord-028721-x6f26ahr 3802 3 frequently frequently RB cord-028721-x6f26ahr 3802 4 found find VBN cord-028721-x6f26ahr 3802 5 within within IN cord-028721-x6f26ahr 3802 6 the the DT cord-028721-x6f26ahr 3802 7 cyst cyst NN cord-028721-x6f26ahr 3802 8 , , , cord-028721-x6f26ahr 3802 9 1616 1616 CD cord-028721-x6f26ahr 3802 10 and and CC cord-028721-x6f26ahr 3802 11 hence hence RB cord-028721-x6f26ahr 3802 12 the the DT cord-028721-x6f26ahr 3802 13 cyst cyst NN cord-028721-x6f26ahr 3802 14 is be VBZ cord-028721-x6f26ahr 3802 15 also also RB cord-028721-x6f26ahr 3802 16 called call VBN cord-028721-x6f26ahr 3802 17 intratesticular intratesticular NNP cord-028721-x6f26ahr 3802 18 spermatocele spermatocele NNP cord-028721-x6f26ahr 3802 19 . . . cord-028721-x6f26ahr 3803 1 1617 1617 CD cord-028721-x6f26ahr 3804 1 It -PRON- PRP cord-028721-x6f26ahr 3804 2 may may MD cord-028721-x6f26ahr 3804 3 be be VB cord-028721-x6f26ahr 3804 4 associated associate VBN cord-028721-x6f26ahr 3804 5 with with IN cord-028721-x6f26ahr 3804 6 cystic cystic JJ cord-028721-x6f26ahr 3804 7 transformation transformation NN cord-028721-x6f26ahr 3804 8 of of IN cord-028721-x6f26ahr 3804 9 the the DT cord-028721-x6f26ahr 3804 10 rete rete NN cord-028721-x6f26ahr 3804 11 testis testis NN cord-028721-x6f26ahr 3804 12 and and CC cord-028721-x6f26ahr 3804 13 multiple multiple JJ cord-028721-x6f26ahr 3804 14 epididymal epididymal JJ cord-028721-x6f26ahr 3804 15 cysts cyst NNS cord-028721-x6f26ahr 3804 16 . . . cord-028721-x6f26ahr 3805 1 Rete Rete NNP cord-028721-x6f26ahr 3805 2 testis testis NN cord-028721-x6f26ahr 3805 3 cyst cyst NN cord-028721-x6f26ahr 3805 4 is be VBZ cord-028721-x6f26ahr 3805 5 not not RB cord-028721-x6f26ahr 3805 6 always always RB cord-028721-x6f26ahr 3805 7 attached attach VBN cord-028721-x6f26ahr 3805 8 to to IN cord-028721-x6f26ahr 3805 9 the the DT cord-028721-x6f26ahr 3805 10 rete rete NN cord-028721-x6f26ahr 3805 11 and and CC cord-028721-x6f26ahr 3805 12 may may MD cord-028721-x6f26ahr 3805 13 be be VB cord-028721-x6f26ahr 3805 14 found find VBN cord-028721-x6f26ahr 3805 15 at at IN cord-028721-x6f26ahr 3805 16 a a DT cord-028721-x6f26ahr 3805 17 distance distance NN cord-028721-x6f26ahr 3805 18 . . . cord-028721-x6f26ahr 3806 1 Simple simple JJ cord-028721-x6f26ahr 3806 2 cyst cyst NN cord-028721-x6f26ahr 3806 3 of of IN cord-028721-x6f26ahr 3806 4 the the DT cord-028721-x6f26ahr 3806 5 testis testis NN cord-028721-x6f26ahr 3806 6 constitutes constitute VBZ cord-028721-x6f26ahr 3806 7 the the DT cord-028721-x6f26ahr 3806 8 remaining remain VBG cord-028721-x6f26ahr 3806 9 intraparenchymal intraparenchymal NNP cord-028721-x6f26ahr 3806 10 cyst cyst NNP cord-028721-x6f26ahr 3806 11 . . . cord-028721-x6f26ahr 3807 1 It -PRON- PRP cord-028721-x6f26ahr 3807 2 is be VBZ cord-028721-x6f26ahr 3807 3 usually usually RB cord-028721-x6f26ahr 3807 4 lined line VBN cord-028721-x6f26ahr 3807 5 by by IN cord-028721-x6f26ahr 3807 6 cuboidal cuboidal JJ cord-028721-x6f26ahr 3807 7 epithelium epithelium NN cord-028721-x6f26ahr 3807 8 and and CC cord-028721-x6f26ahr 3807 9 contains contain VBZ cord-028721-x6f26ahr 3807 10 no no DT cord-028721-x6f26ahr 3807 11 spermatozoa spermatozoa NN cord-028721-x6f26ahr 3807 12 . . . cord-028721-x6f26ahr 3808 1 1618 1618 CD cord-028721-x6f26ahr 3808 2 , , , cord-028721-x6f26ahr 3808 3 1619 1619 CD cord-028721-x6f26ahr 3809 1 Simple simple JJ cord-028721-x6f26ahr 3809 2 cyst cyst NN cord-028721-x6f26ahr 3809 3 ranges range VBZ cord-028721-x6f26ahr 3809 4 Other other JJ cord-028721-x6f26ahr 3809 5 testicular testicular JJ cord-028721-x6f26ahr 3809 6 diseases disease NNS cord-028721-x6f26ahr 3809 7 from from IN cord-028721-x6f26ahr 3809 8 2 2 CD cord-028721-x6f26ahr 3809 9 nm nm NN cord-028721-x6f26ahr 3809 10 to to IN cord-028721-x6f26ahr 3809 11 18 18 CD cord-028721-x6f26ahr 3809 12 mm mm NNS cord-028721-x6f26ahr 3809 13 in in IN cord-028721-x6f26ahr 3809 14 diameter diameter NN cord-028721-x6f26ahr 3809 15 . . . cord-028721-x6f26ahr 3810 1 1620 1620 CD cord-028721-x6f26ahr 3810 2 , , , cord-028721-x6f26ahr 3810 3 1621 1621 CD cord-028721-x6f26ahr 3810 4 The the DT cord-028721-x6f26ahr 3810 5 disorders disorder NNS cord-028721-x6f26ahr 3810 6 occurs occur VBZ cord-028721-x6f26ahr 3810 7 at at IN cord-028721-x6f26ahr 3810 8 any any DT cord-028721-x6f26ahr 3810 9 age age NN cord-028721-x6f26ahr 3810 10 , , , cord-028721-x6f26ahr 3810 11 from from IN cord-028721-x6f26ahr 3810 12 5 5 CD cord-028721-x6f26ahr 3810 13 months month NNS cord-028721-x6f26ahr 3810 14 to to IN cord-028721-x6f26ahr 3810 15 80 80 CD cord-028721-x6f26ahr 3810 16 years year NNS cord-028721-x6f26ahr 3810 17 , , , cord-028721-x6f26ahr 3810 18 with with IN cord-028721-x6f26ahr 3810 19 a a DT cord-028721-x6f26ahr 3810 20 bimodal bimodal JJ cord-028721-x6f26ahr 3810 21 distribution distribution NN cord-028721-x6f26ahr 3810 22 with with IN cord-028721-x6f26ahr 3810 23 peaks peak NNS cord-028721-x6f26ahr 3810 24 at at IN cord-028721-x6f26ahr 3810 25 8 8 CD cord-028721-x6f26ahr 3810 26 month month NN cord-028721-x6f26ahr 3810 27 and and CC cord-028721-x6f26ahr 3810 28 60 60 CD cord-028721-x6f26ahr 3810 29 years year NNS cord-028721-x6f26ahr 3810 30 . . . cord-028721-x6f26ahr 3811 1 1622 1622 CD cord-028721-x6f26ahr 3811 2 It -PRON- PRP cord-028721-x6f26ahr 3811 3 may may MD cord-028721-x6f26ahr 3811 4 occur occur VB cord-028721-x6f26ahr 3811 5 bilaterally bilaterally RB cord-028721-x6f26ahr 3811 6 , , , cord-028721-x6f26ahr 3811 7 1623 1623 CD cord-028721-x6f26ahr 3811 8 and and CC cord-028721-x6f26ahr 3811 9 may may MD cord-028721-x6f26ahr 3811 10 present present VB cord-028721-x6f26ahr 3811 11 as as IN cord-028721-x6f26ahr 3811 12 two two CD cord-028721-x6f26ahr 3811 13 cysts cyst NNS cord-028721-x6f26ahr 3811 14 in in IN cord-028721-x6f26ahr 3811 15 the the DT cord-028721-x6f26ahr 3811 16 same same JJ cord-028721-x6f26ahr 3811 17 testis testis NN cord-028721-x6f26ahr 3811 18 . . . cord-028721-x6f26ahr 3812 1 1624 1624 CD cord-028721-x6f26ahr 3812 2 Origin Origin NNP cord-028721-x6f26ahr 3812 3 of of IN cord-028721-x6f26ahr 3812 4 the the DT cord-028721-x6f26ahr 3812 5 three three CD cord-028721-x6f26ahr 3812 6 types type NNS cord-028721-x6f26ahr 3812 7 of of IN cord-028721-x6f26ahr 3812 8 testicular testicular JJ cord-028721-x6f26ahr 3812 9 cyst cyst NN cord-028721-x6f26ahr 3812 10 is be VBZ cord-028721-x6f26ahr 3812 11 uncertain uncertain JJ cord-028721-x6f26ahr 3812 12 . . . cord-028721-x6f26ahr 3813 1 Previously previously RB cord-028721-x6f26ahr 3813 2 , , , cord-028721-x6f26ahr 3813 3 traumatic traumatic JJ cord-028721-x6f26ahr 3813 4 1625 1625 CD cord-028721-x6f26ahr 3813 5 and and CC cord-028721-x6f26ahr 3813 6 infl infl NNP cord-028721-x6f26ahr 3813 7 ammatory ammatory NNP cord-028721-x6f26ahr 3813 8 1626 1626 CD cord-028721-x6f26ahr 3813 9 origins origin NNS cord-028721-x6f26ahr 3813 10 were be VBD cord-028721-x6f26ahr 3813 11 attributed attribute VBN cord-028721-x6f26ahr 3813 12 to to IN cord-028721-x6f26ahr 3813 13 tunica tunica NNP cord-028721-x6f26ahr 3813 14 albuginea albuginea NNP cord-028721-x6f26ahr 3813 15 cyst cyst NNP cord-028721-x6f26ahr 3813 16 , , , cord-028721-x6f26ahr 3813 17 but but CC cord-028721-x6f26ahr 3813 18 most most JJS cord-028721-x6f26ahr 3813 19 now now RB cord-028721-x6f26ahr 3813 20 believe believe VBP cord-028721-x6f26ahr 3813 21 that that IN cord-028721-x6f26ahr 3813 22 they -PRON- PRP cord-028721-x6f26ahr 3813 23 are be VBP cord-028721-x6f26ahr 3813 24 derived derive VBN cord-028721-x6f26ahr 3813 25 from from IN cord-028721-x6f26ahr 3813 26 embryonal embryonal JJ cord-028721-x6f26ahr 3813 27 remnants remnant NNS cord-028721-x6f26ahr 3813 28 of of IN cord-028721-x6f26ahr 3813 29 the the DT cord-028721-x6f26ahr 3813 30 mesonephric mesonephric JJ cord-028721-x6f26ahr 3813 31 ducts duct NNS cord-028721-x6f26ahr 3813 32 1615 1615 CD cord-028721-x6f26ahr 3813 33 , , , cord-028721-x6f26ahr 3813 34 1627 1627 CD cord-028721-x6f26ahr 3813 35 or or CC cord-028721-x6f26ahr 3813 36 mesothelial mesothelial JJ cord-028721-x6f26ahr 3813 37 cells cell NNS cord-028721-x6f26ahr 3813 38 embedded embed VBN cord-028721-x6f26ahr 3813 39 in in IN cord-028721-x6f26ahr 3813 40 the the DT cord-028721-x6f26ahr 3813 41 tunica tunica NNP cord-028721-x6f26ahr 3813 42 albuginea albuginea NNP cord-028721-x6f26ahr 3813 43 during during IN cord-028721-x6f26ahr 3813 44 embryogenesis embryogenesis NN cord-028721-x6f26ahr 3813 45 . . . cord-028721-x6f26ahr 3814 1 1614 1614 CD cord-028721-x6f26ahr 3814 2 , , , cord-028721-x6f26ahr 3814 3 1628 1628 CD cord-028721-x6f26ahr 3814 4 , , , cord-028721-x6f26ahr 3814 5 1629 1629 CD cord-028721-x6f26ahr 3814 6 Simple simple JJ cord-028721-x6f26ahr 3814 7 cyst cyst NN cord-028721-x6f26ahr 3814 8 of of IN cord-028721-x6f26ahr 3814 9 the the DT cord-028721-x6f26ahr 3814 10 testis testis NN cord-028721-x6f26ahr 3814 11 may may MD cord-028721-x6f26ahr 3814 12 also also RB cord-028721-x6f26ahr 3814 13 have have VB cord-028721-x6f26ahr 3814 14 a a DT cord-028721-x6f26ahr 3814 15 mesothelial mesothelial JJ cord-028721-x6f26ahr 3814 16 origin origin NN cord-028721-x6f26ahr 3814 17 , , , cord-028721-x6f26ahr 3814 18 but but CC cord-028721-x6f26ahr 3814 19 it -PRON- PRP cord-028721-x6f26ahr 3814 20 is be VBZ cord-028721-x6f26ahr 3814 21 possible possible JJ cord-028721-x6f26ahr 3814 22 that that IN cord-028721-x6f26ahr 3814 23 some some DT cord-028721-x6f26ahr 3814 24 arise arise VBP cord-028721-x6f26ahr 3814 25 from from IN cord-028721-x6f26ahr 3814 26 ectopic ectopic JJ cord-028721-x6f26ahr 3814 27 rete rete FW cord-028721-x6f26ahr 3814 28 testis testis NN cord-028721-x6f26ahr 3814 29 epithelium epithelium NN cord-028721-x6f26ahr 3814 30 . . . cord-028721-x6f26ahr 3815 1 These these DT cord-028721-x6f26ahr 3815 2 cysts cyst NNS cord-028721-x6f26ahr 3815 3 are be VBP cord-028721-x6f26ahr 3815 4 unrelated unrelated JJ cord-028721-x6f26ahr 3815 5 to to IN cord-028721-x6f26ahr 3815 6 epidermoid epidermoid JJ cord-028721-x6f26ahr 3815 7 cyst cyst NN cord-028721-x6f26ahr 3815 8 , , , cord-028721-x6f26ahr 3815 9 differing differ VBG cord-028721-x6f26ahr 3815 10 in in IN cord-028721-x6f26ahr 3815 11 the the DT cord-028721-x6f26ahr 3815 12 ultrasonographic ultrasonographic JJ cord-028721-x6f26ahr 3815 13 1630,1631 1630,1631 CD cord-028721-x6f26ahr 3815 14 and and CC cord-028721-x6f26ahr 3815 15 histologic histologic JJ cord-028721-x6f26ahr 3815 16 features feature NNS cord-028721-x6f26ahr 3815 17 ( ( -LRB- cord-028721-x6f26ahr 3815 18 see see VB cord-028721-x6f26ahr 3815 19 discussion discussion NN cord-028721-x6f26ahr 3815 20 on on IN cord-028721-x6f26ahr 3815 21 cystic cystic JJ cord-028721-x6f26ahr 3815 22 dysplasia dysplasia NN cord-028721-x6f26ahr 3815 23 and and CC cord-028721-x6f26ahr 3815 24 testicular testicular JJ cord-028721-x6f26ahr 3815 25 tumors tumor NNS cord-028721-x6f26ahr 3815 26 in in IN cord-028721-x6f26ahr 3815 27 the the DT cord-028721-x6f26ahr 3815 28 section section NN cord-028721-x6f26ahr 3815 29 on on IN cord-028721-x6f26ahr 3815 30 hamartomatous hamartomatous JJ cord-028721-x6f26ahr 3815 31 testicular testicular JJ cord-028721-x6f26ahr 3815 32 lesions lesion NNS cord-028721-x6f26ahr 3815 33 ) ) -RRB- cord-028721-x6f26ahr 3815 34 . . . cord-028721-x6f26ahr 3816 1 Ultrasound ultrasound NN cord-028721-x6f26ahr 3816 2 studies study NNS cord-028721-x6f26ahr 3816 3 indicate indicate VBP cord-028721-x6f26ahr 3816 4 that that IN cord-028721-x6f26ahr 3816 5 testicular testicular JJ cord-028721-x6f26ahr 3816 6 cyst cyst NN cord-028721-x6f26ahr 3816 7 has have VBZ cord-028721-x6f26ahr 3816 8 little little JJ cord-028721-x6f26ahr 3816 9 potential potential NN cord-028721-x6f26ahr 3816 10 for for IN cord-028721-x6f26ahr 3816 11 growth growth NN cord-028721-x6f26ahr 3816 12 . . . cord-028721-x6f26ahr 3817 1 1630,1632 1630,1632 CD cord-028721-x6f26ahr 3818 1 Currently currently RB cord-028721-x6f26ahr 3818 2 , , , cord-028721-x6f26ahr 3818 3 excision excision NN cord-028721-x6f26ahr 3818 4 is be VBZ cord-028721-x6f26ahr 3818 5 recommended recommend VBN cord-028721-x6f26ahr 3818 6 only only RB cord-028721-x6f26ahr 3818 7 in in IN cord-028721-x6f26ahr 3818 8 children child NNS cord-028721-x6f26ahr 3818 9 when when WRB cord-028721-x6f26ahr 3818 10 the the DT cord-028721-x6f26ahr 3818 11 cyst cyst NN cord-028721-x6f26ahr 3818 12 may may MD cord-028721-x6f26ahr 3818 13 impair impair VB cord-028721-x6f26ahr 3818 14 testicular testicular JJ cord-028721-x6f26ahr 3818 15 development development NN cord-028721-x6f26ahr 3818 16 . . . cord-028721-x6f26ahr 3819 1 1633 1633 CD cord-028721-x6f26ahr 3819 2 _SP cord-028721-x6f26ahr 3820 1 Dysgenesis Dysgenesis NNP cord-028721-x6f26ahr 3820 2 of of IN cord-028721-x6f26ahr 3820 3 the the DT cord-028721-x6f26ahr 3820 4 rete rete NN cord-028721-x6f26ahr 3820 5 testis testis NN cord-028721-x6f26ahr 3820 6 is be VBZ cord-028721-x6f26ahr 3820 7 characterized characterize VBN cord-028721-x6f26ahr 3820 8 by by IN cord-028721-x6f26ahr 3820 9 inadequate inadequate JJ cord-028721-x6f26ahr 3820 10 maturation maturation NN cord-028721-x6f26ahr 3820 11 and and CC cord-028721-x6f26ahr 3820 12 persistence persistence NN cord-028721-x6f26ahr 3820 13 of of IN cord-028721-x6f26ahr 3820 14 infantile infantile JJ cord-028721-x6f26ahr 3820 15 or or CC cord-028721-x6f26ahr 3820 16 pubertal pubertal JJ cord-028721-x6f26ahr 3820 17 characteristics characteristic NNS cord-028721-x6f26ahr 3820 18 in in IN cord-028721-x6f26ahr 3820 19 adults adult NNS cord-028721-x6f26ahr 3820 20 . . . cord-028721-x6f26ahr 3821 1 1634 1634 CD cord-028721-x6f26ahr 3822 1 This this DT cord-028721-x6f26ahr 3822 2 disorder disorder NN cord-028721-x6f26ahr 3822 3 is be VBZ cord-028721-x6f26ahr 3822 4 frequent frequent JJ cord-028721-x6f26ahr 3822 5 in in IN cord-028721-x6f26ahr 3822 6 undescended undescended JJ cord-028721-x6f26ahr 3822 7 adult adult NN cord-028721-x6f26ahr 3822 8 testes testis NNS cord-028721-x6f26ahr 3822 9 . . . cord-028721-x6f26ahr 3823 1 The the DT cord-028721-x6f26ahr 3823 2 lesion lesion NN cord-028721-x6f26ahr 3823 3 involves involve VBZ cord-028721-x6f26ahr 3823 4 the the DT cord-028721-x6f26ahr 3823 5 rete rete NN cord-028721-x6f26ahr 3823 6 testis testis NN cord-028721-x6f26ahr 3823 7 segments segment NNS cord-028721-x6f26ahr 3823 8 referred refer VBD cord-028721-x6f26ahr 3823 9 to to IN cord-028721-x6f26ahr 3823 10 as as RB cord-028721-x6f26ahr 3823 11 septal septal JJ cord-028721-x6f26ahr 3823 12 , , , cord-028721-x6f26ahr 3823 13 mediastinal mediastinal JJ cord-028721-x6f26ahr 3823 14 , , , cord-028721-x6f26ahr 3823 15 and and CC cord-028721-x6f26ahr 3823 16 extratesticular extratesticular JJ cord-028721-x6f26ahr 3823 17 . . . cord-028721-x6f26ahr 3824 1 There there EX cord-028721-x6f26ahr 3824 2 is be VBZ cord-028721-x6f26ahr 3824 3 poor poor JJ cord-028721-x6f26ahr 3824 4 development development NN cord-028721-x6f26ahr 3824 5 of of IN cord-028721-x6f26ahr 3824 6 the the DT cord-028721-x6f26ahr 3824 7 cavities cavity NNS cord-028721-x6f26ahr 3824 8 and and CC cord-028721-x6f26ahr 3824 9 their -PRON- PRP$ cord-028721-x6f26ahr 3824 10 epithelial epithelial JJ cord-028721-x6f26ahr 3824 11 lining lining NN cord-028721-x6f26ahr 3824 12 , , , cord-028721-x6f26ahr 3824 13 which which WDT cord-028721-x6f26ahr 3824 14 becomes become VBZ cord-028721-x6f26ahr 3824 15 cuboidal cuboidal JJ cord-028721-x6f26ahr 3824 16 or or CC cord-028721-x6f26ahr 3824 17 columnar columnar JJ cord-028721-x6f26ahr 3824 18 instead instead RB cord-028721-x6f26ahr 3824 19 of of IN cord-028721-x6f26ahr 3824 20 fl fl NNP cord-028721-x6f26ahr 3824 21 attened attene VBN cord-028721-x6f26ahr 3824 22 with with IN cord-028721-x6f26ahr 3824 23 areas area NNS cord-028721-x6f26ahr 3824 24 of of IN cord-028721-x6f26ahr 3824 25 columnar columnar JJ cord-028721-x6f26ahr 3824 26 cells cell NNS cord-028721-x6f26ahr 3824 27 . . . cord-028721-x6f26ahr 3825 1 The the DT cord-028721-x6f26ahr 3825 2 lumina lumina NN cord-028721-x6f26ahr 3825 3 of of IN cord-028721-x6f26ahr 3825 4 the the DT cord-028721-x6f26ahr 3825 5 rete rete NNP cord-028721-x6f26ahr 3825 6 testis testis NN cord-028721-x6f26ahr 3825 7 cavities cavity NNS cord-028721-x6f26ahr 3825 8 may may MD cord-028721-x6f26ahr 3825 9 be be VB cord-028721-x6f26ahr 3825 10 completely completely RB cord-028721-x6f26ahr 3825 11 absent absent JJ cord-028721-x6f26ahr 3825 12 ( ( -LRB- cord-028721-x6f26ahr 3825 13 simple simple JJ cord-028721-x6f26ahr 3825 14 hypoplasia hypoplasia NN cord-028721-x6f26ahr 3825 15 ) ) -RRB- cord-028721-x6f26ahr 3825 16 or or CC cord-028721-x6f26ahr 3825 17 , , , cord-028721-x6f26ahr 3825 18 conversely conversely RB cord-028721-x6f26ahr 3825 19 , , , cord-028721-x6f26ahr 3825 20 undergo undergo VB cord-028721-x6f26ahr 3825 21 microcystic microcystic JJ cord-028721-x6f26ahr 3825 22 dilation dilation NN cord-028721-x6f26ahr 3825 23 ( ( -LRB- cord-028721-x6f26ahr 3825 24 cystic cystic JJ cord-028721-x6f26ahr 3825 25 hypoplasia hypoplasia NNP cord-028721-x6f26ahr 3825 26 ) ) -RRB- cord-028721-x6f26ahr 3825 27 . . . cord-028721-x6f26ahr 3826 1 In in IN cord-028721-x6f26ahr 3826 2 a a DT cord-028721-x6f26ahr 3826 3 few few JJ cord-028721-x6f26ahr 3826 4 cases case NNS cord-028721-x6f26ahr 3826 5 , , , cord-028721-x6f26ahr 3826 6 the the DT cord-028721-x6f26ahr 3826 7 rete rete NNP cord-028721-x6f26ahr 3826 8 testis testis NN cord-028721-x6f26ahr 3826 9 develops develop VBZ cord-028721-x6f26ahr 3826 10 papillary papillary JJ cord-028721-x6f26ahr 3826 11 , , , cord-028721-x6f26ahr 3826 12 cribriform cribriform NNP cord-028721-x6f26ahr 3826 13 , , , cord-028721-x6f26ahr 3826 14 or or CC cord-028721-x6f26ahr 3826 15 tubular tubular JJ cord-028721-x6f26ahr 3826 16 formations formation NNS cord-028721-x6f26ahr 3826 17 ( ( -LRB- cord-028721-x6f26ahr 3826 18 adenomatous adenomatous JJ cord-028721-x6f26ahr 3826 19 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3826 20 ) ) -RRB- cord-028721-x6f26ahr 3826 21 . . . cord-028721-x6f26ahr 3827 1 The the DT cord-028721-x6f26ahr 3827 2 epithelium epithelium NN cord-028721-x6f26ahr 3827 3 of of IN cord-028721-x6f26ahr 3827 4 the the DT cord-028721-x6f26ahr 3827 5 rete rete NN cord-028721-x6f26ahr 3827 6 testis testis NN cord-028721-x6f26ahr 3827 7 is be VBZ cord-028721-x6f26ahr 3827 8 usually usually RB cord-028721-x6f26ahr 3827 9 fl fl NNP cord-028721-x6f26ahr 3827 10 attened attene VBD cord-028721-x6f26ahr 3827 11 , , , cord-028721-x6f26ahr 3827 12 with with IN cord-028721-x6f26ahr 3827 13 scattered scatter VBN cord-028721-x6f26ahr 3827 14 areas area NNS cord-028721-x6f26ahr 3827 15 of of IN cord-028721-x6f26ahr 3827 16 columnar columnar JJ cord-028721-x6f26ahr 3827 17 cells cell NNS cord-028721-x6f26ahr 3827 18 . . . cord-028721-x6f26ahr 3828 1 In in IN cord-028721-x6f26ahr 3828 2 estrogen estrogen NN cord-028721-x6f26ahr 3828 3 - - HYPH cord-028721-x6f26ahr 3828 4 treated treat VBN cord-028721-x6f26ahr 3828 5 patients patient NNS cord-028721-x6f26ahr 3828 6 , , , cord-028721-x6f26ahr 3828 7 those those DT cord-028721-x6f26ahr 3828 8 with with IN cord-028721-x6f26ahr 3828 9 chronic chronic JJ cord-028721-x6f26ahr 3828 10 hepatic hepatic JJ cord-028721-x6f26ahr 3828 11 insuffi insuffi NN cord-028721-x6f26ahr 3828 12 ciency ciency NN cord-028721-x6f26ahr 3828 13 , , , cord-028721-x6f26ahr 3828 14 functioning function VBG cord-028721-x6f26ahr 3828 15 tumor tumor NN cord-028721-x6f26ahr 3828 16 that that WDT cord-028721-x6f26ahr 3828 17 secretes secrete VBZ cord-028721-x6f26ahr 3828 18 estrogens estrogen NNS cord-028721-x6f26ahr 3828 19 or or CC cord-028721-x6f26ahr 3828 20 human human JJ cord-028721-x6f26ahr 3828 21 chorionic chorionic JJ cord-028721-x6f26ahr 3828 22 gonadotropin gonadotropin NN cord-028721-x6f26ahr 3828 23 , , , cord-028721-x6f26ahr 3828 24 and and CC cord-028721-x6f26ahr 3828 25 other other JJ cord-028721-x6f26ahr 3828 26 disorders disorder NNS cord-028721-x6f26ahr 3828 27 that that WDT cord-028721-x6f26ahr 3828 28 are be VBP cord-028721-x6f26ahr 3828 29 described describe VBN cord-028721-x6f26ahr 3828 30 as as IN cord-028721-x6f26ahr 3828 31 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3828 32 of of IN cord-028721-x6f26ahr 3828 33 the the DT cord-028721-x6f26ahr 3828 34 rete rete NN cord-028721-x6f26ahr 3828 35 testis testis NN cord-028721-x6f26ahr 3828 36 it -PRON- PRP cord-028721-x6f26ahr 3828 37 may may MD cord-028721-x6f26ahr 3828 38 undergo undergo VB cord-028721-x6f26ahr 3828 39 diffuse diffuse VB cord-028721-x6f26ahr 3828 40 transformation transformation NN cord-028721-x6f26ahr 3828 41 into into IN cord-028721-x6f26ahr 3828 42 tall tall JJ cord-028721-x6f26ahr 3828 43 columnar columnar JJ cord-028721-x6f26ahr 3828 44 epithelium epithelium NN cord-028721-x6f26ahr 3828 45 . . . cord-028721-x6f26ahr 3829 1 Except except IN cord-028721-x6f26ahr 3829 2 for for IN cord-028721-x6f26ahr 3829 3 the the DT cord-028721-x6f26ahr 3829 4 latter latter JJ cord-028721-x6f26ahr 3829 5 group group NN cord-028721-x6f26ahr 3829 6 , , , cord-028721-x6f26ahr 3829 7 metaplasia metaplasia NN cord-028721-x6f26ahr 3829 8 of of IN cord-028721-x6f26ahr 3829 9 the the DT cord-028721-x6f26ahr 3829 10 rete rete NN cord-028721-x6f26ahr 3829 11 testis testis NN cord-028721-x6f26ahr 3829 12 seems seem VBZ cord-028721-x6f26ahr 3829 13 to to TO cord-028721-x6f26ahr 3829 14 be be VB cord-028721-x6f26ahr 3829 15 an an DT cord-028721-x6f26ahr 3829 16 estrogen estrogen NN cord-028721-x6f26ahr 3829 17 - - HYPH cord-028721-x6f26ahr 3829 18 dependent dependent JJ cord-028721-x6f26ahr 3829 19 process process NN cord-028721-x6f26ahr 3829 20 , , , cord-028721-x6f26ahr 3829 21 and and CC cord-028721-x6f26ahr 3829 22 estrogen estrogen NN cord-028721-x6f26ahr 3829 23 receptors receptor NNS cord-028721-x6f26ahr 3829 24 are be VBP cord-028721-x6f26ahr 3829 25 present present JJ cord-028721-x6f26ahr 3829 26 in in IN cord-028721-x6f26ahr 3829 27 the the DT cord-028721-x6f26ahr 3829 28 rete rete NN cord-028721-x6f26ahr 3829 29 testis testis NN cord-028721-x6f26ahr 3829 30 epithelium epithelium NN cord-028721-x6f26ahr 3829 31 . . . cord-028721-x6f26ahr 3830 1 1635 1635 CD cord-028721-x6f26ahr 3831 1 Acquired acquire VBN cord-028721-x6f26ahr 3831 2 cystic cystic JJ cord-028721-x6f26ahr 3831 3 transformation transformation NN cord-028721-x6f26ahr 3831 4 of of IN cord-028721-x6f26ahr 3831 5 the the DT cord-028721-x6f26ahr 3831 6 rete rete NN cord-028721-x6f26ahr 3831 7 testis testis NN cord-028721-x6f26ahr 3831 8 is be VBZ cord-028721-x6f26ahr 3831 9 common common JJ cord-028721-x6f26ahr 3831 10 , , , cord-028721-x6f26ahr 3831 11 and and CC cord-028721-x6f26ahr 3831 12 its -PRON- PRP$ cord-028721-x6f26ahr 3831 13 incidence incidence NN cord-028721-x6f26ahr 3831 14 increases increase VBZ cord-028721-x6f26ahr 3831 15 with with IN cord-028721-x6f26ahr 3831 16 age age NN cord-028721-x6f26ahr 3831 17 and and CC cord-028721-x6f26ahr 3831 18 associated associated JJ cord-028721-x6f26ahr 3831 19 disorders disorder NNS cord-028721-x6f26ahr 3831 20 . . . cord-028721-x6f26ahr 3832 1 1636 1636 CD cord-028721-x6f26ahr 3832 2 Ultrasound Ultrasound NNP cord-028721-x6f26ahr 3832 3 1637 1637 CD cord-028721-x6f26ahr 3832 4 Ultrasound Ultrasound NNP cord-028721-x6f26ahr 3832 5 , , , cord-028721-x6f26ahr 3832 6 1638 1638 CD cord-028721-x6f26ahr 3832 7 and and CC cord-028721-x6f26ahr 3832 8 magnetic magnetic JJ cord-028721-x6f26ahr 3832 9 resonance resonance NN cord-028721-x6f26ahr 3832 10 1639 1639 CD cord-028721-x6f26ahr 3832 11 studies study NNS cord-028721-x6f26ahr 3832 12 reveal reveal VBP cord-028721-x6f26ahr 3832 13 characteristic characteristic JJ cord-028721-x6f26ahr 3832 14 images image NNS cord-028721-x6f26ahr 3832 15 that that WDT cord-028721-x6f26ahr 3832 16 may may MD cord-028721-x6f26ahr 3832 17 suggest suggest VB cord-028721-x6f26ahr 3832 18 malignancy malignancy NN cord-028721-x6f26ahr 3832 19 . . . cord-028721-x6f26ahr 3833 1 The the DT cord-028721-x6f26ahr 3833 2 lesion lesion NN cord-028721-x6f26ahr 3833 3 has have VBZ cord-028721-x6f26ahr 3833 4 three three CD cord-028721-x6f26ahr 3833 5 forms form NNS cord-028721-x6f26ahr 3833 6 : : : cord-028721-x6f26ahr 3833 7 simple simple JJ cord-028721-x6f26ahr 3833 8 , , , cord-028721-x6f26ahr 3833 9 associated associate VBN cord-028721-x6f26ahr 3833 10 with with IN cord-028721-x6f26ahr 3833 11 epithelial epithelial JJ cord-028721-x6f26ahr 3833 12 metaplasia metaplasia NN cord-028721-x6f26ahr 3833 13 , , , cord-028721-x6f26ahr 3833 14 and and CC cord-028721-x6f26ahr 3833 15 with with IN cord-028721-x6f26ahr 3833 16 crystalline crystalline JJ cord-028721-x6f26ahr 3833 17 deposits deposit NNS cord-028721-x6f26ahr 3833 18 . . . cord-028721-x6f26ahr 3834 1 Simple simple JJ cord-028721-x6f26ahr 3834 2 cystic cystic JJ cord-028721-x6f26ahr 3834 3 transformation transformation NN cord-028721-x6f26ahr 3834 4 consists consist VBZ cord-028721-x6f26ahr 3834 5 of of IN cord-028721-x6f26ahr 3834 6 dilated dilated JJ cord-028721-x6f26ahr 3834 7 cavities cavity NNS cord-028721-x6f26ahr 3834 8 with with IN cord-028721-x6f26ahr 3834 9 normal normal JJ cord-028721-x6f26ahr 3834 10 epithelium epithelium NN cord-028721-x6f26ahr 3834 11 . . . cord-028721-x6f26ahr 3835 1 It -PRON- PRP cord-028721-x6f26ahr 3835 2 results result VBZ cord-028721-x6f26ahr 3835 3 from from IN cord-028721-x6f26ahr 3835 4 obstruction obstruction NN cord-028721-x6f26ahr 3835 5 of of IN cord-028721-x6f26ahr 3835 6 the the DT cord-028721-x6f26ahr 3835 7 epididymis epididymis NN cord-028721-x6f26ahr 3835 8 or or CC cord-028721-x6f26ahr 3835 9 the the DT cord-028721-x6f26ahr 3835 10 initial initial JJ cord-028721-x6f26ahr 3835 11 portion portion NN cord-028721-x6f26ahr 3835 12 of of IN cord-028721-x6f26ahr 3835 13 the the DT cord-028721-x6f26ahr 3835 14 vas vas FW cord-028721-x6f26ahr 3835 15 deferens deferen NNS cord-028721-x6f26ahr 3835 16 due due IN cord-028721-x6f26ahr 3835 17 to to IN cord-028721-x6f26ahr 3835 18 ischemia ischemia NN cord-028721-x6f26ahr 3835 19 ( ( -LRB- cord-028721-x6f26ahr 3835 20 aging age VBG cord-028721-x6f26ahr 3835 21 men man NNS cord-028721-x6f26ahr 3835 22 ) ) -RRB- cord-028721-x6f26ahr 3835 23 ; ; : cord-028721-x6f26ahr 3835 24 compression compression NN cord-028721-x6f26ahr 3835 25 by by IN cord-028721-x6f26ahr 3835 26 epididymal epididymal JJ cord-028721-x6f26ahr 3835 27 and and CC cord-028721-x6f26ahr 3835 28 spermatic spermatic JJ cord-028721-x6f26ahr 3835 29 cord cord NN cord-028721-x6f26ahr 3835 30 tumor tumor NN cord-028721-x6f26ahr 3835 31 , , , cord-028721-x6f26ahr 3835 32 or or CC cord-028721-x6f26ahr 3835 33 by by IN cord-028721-x6f26ahr 3835 34 congestive congestive JJ cord-028721-x6f26ahr 3835 35 veins vein NNS cord-028721-x6f26ahr 3835 36 in in IN cord-028721-x6f26ahr 3835 37 varicocele varicocele NN cord-028721-x6f26ahr 3835 38 ; ; : cord-028721-x6f26ahr 3835 39 infl infl NNP cord-028721-x6f26ahr 3835 40 ammation ammation NN cord-028721-x6f26ahr 3835 41 in in IN cord-028721-x6f26ahr 3835 42 patients patient NNS cord-028721-x6f26ahr 3835 43 with with IN cord-028721-x6f26ahr 3835 44 previous previous JJ cord-028721-x6f26ahr 3835 45 epididymitis epididymitis NN cord-028721-x6f26ahr 3835 46 ; ; : cord-028721-x6f26ahr 3835 47 malformation malformation NN cord-028721-x6f26ahr 3835 48 ( ( -LRB- cord-028721-x6f26ahr 3835 49 testis testis NN cord-028721-x6f26ahr 3835 50 - - HYPH cord-028721-x6f26ahr 3835 51 epididymis epididymis NN cord-028721-x6f26ahr 3835 52 dissociation dissociation NN cord-028721-x6f26ahr 3835 53 , , , cord-028721-x6f26ahr 3835 54 malformed malformed JJ cord-028721-x6f26ahr 3835 55 epididymis epididymis NN cord-028721-x6f26ahr 3835 56 and and CC cord-028721-x6f26ahr 3835 57 absence absence NN cord-028721-x6f26ahr 3835 58 of of IN cord-028721-x6f26ahr 3835 59 the the DT cord-028721-x6f26ahr 3835 60 vas vas NNP cord-028721-x6f26ahr 3835 61 deferens deferens NNP cord-028721-x6f26ahr 3835 62 ) ) -RRB- cord-028721-x6f26ahr 3835 63 ; ; : cord-028721-x6f26ahr 3835 64 1640 1640 CD cord-028721-x6f26ahr 3835 65 or or CC cord-028721-x6f26ahr 3835 66 iatrogenic iatrogenic JJ cord-028721-x6f26ahr 3835 67 causes cause NNS cord-028721-x6f26ahr 3835 68 ( ( -LRB- cord-028721-x6f26ahr 3835 69 surgery surgery NN cord-028721-x6f26ahr 3835 70 for for IN cord-028721-x6f26ahr 3835 71 epididymoectomy epididymoectomy NN cord-028721-x6f26ahr 3835 72 or or CC cord-028721-x6f26ahr 3835 73 removal removal NN cord-028721-x6f26ahr 3835 74 of of IN cord-028721-x6f26ahr 3835 75 epididymal epididymal JJ cord-028721-x6f26ahr 3835 76 cyst cyst NN cord-028721-x6f26ahr 3835 77 ) ) -RRB- cord-028721-x6f26ahr 3836 1 ( ( -LRB- cord-028721-x6f26ahr 3836 2 Fig Fig NNP cord-028721-x6f26ahr 3836 3 . . . cord-028721-x6f26ahr 3836 4 12 12 CD cord-028721-x6f26ahr 3836 5 - - SYM cord-028721-x6f26ahr 3836 6 170 170 CD cord-028721-x6f26ahr 3836 7 ) ) -RRB- cord-028721-x6f26ahr 3836 8 . . . cord-028721-x6f26ahr 3837 1 1641 1641 CD cord-028721-x6f26ahr 3837 2 Cystic cystic JJ cord-028721-x6f26ahr 3837 3 transformation transformation NN cord-028721-x6f26ahr 3837 4 with with IN cord-028721-x6f26ahr 3837 5 epithelial epithelial JJ cord-028721-x6f26ahr 3837 6 metaplasia metaplasia NN cord-028721-x6f26ahr 3837 7 is be VBZ cord-028721-x6f26ahr 3837 8 a a DT cord-028721-x6f26ahr 3837 9 frequent frequent JJ cord-028721-x6f26ahr 3837 10 fi fi NN cord-028721-x6f26ahr 3837 11 nding nding NN cord-028721-x6f26ahr 3837 12 at at IN cord-028721-x6f26ahr 3837 13 autopsy autopsy NN cord-028721-x6f26ahr 3837 14 . . . cord-028721-x6f26ahr 3838 1 1369 1369 CD cord-028721-x6f26ahr 3839 1 Its -PRON- PRP$ cord-028721-x6f26ahr 3839 2 development development NN cord-028721-x6f26ahr 3839 3 is be VBZ cord-028721-x6f26ahr 3839 4 probably probably RB cord-028721-x6f26ahr 3839 5 due due JJ cord-028721-x6f26ahr 3839 6 to to IN cord-028721-x6f26ahr 3839 7 the the DT cord-028721-x6f26ahr 3839 8 concurrence concurrence NN cord-028721-x6f26ahr 3839 9 of of IN cord-028721-x6f26ahr 3839 10 sperm sperm NN cord-028721-x6f26ahr 3839 11 excretory excretory JJ cord-028721-x6f26ahr 3839 12 duct duct NN cord-028721-x6f26ahr 3839 13 obstruction obstruction NN cord-028721-x6f26ahr 3839 14 and and CC cord-028721-x6f26ahr 3839 15 conditions condition NNS cord-028721-x6f26ahr 3839 16 involved involve VBN cord-028721-x6f26ahr 3839 17 in in IN cord-028721-x6f26ahr 3839 18 increased increase VBN cord-028721-x6f26ahr 3839 19 serum serum NN cord-028721-x6f26ahr 3839 20 estrogen estrogen NN cord-028721-x6f26ahr 3839 21 levels level NNS cord-028721-x6f26ahr 3839 22 , , , cord-028721-x6f26ahr 3839 23 such such JJ cord-028721-x6f26ahr 3839 24 as as IN cord-028721-x6f26ahr 3839 25 chronic chronic JJ cord-028721-x6f26ahr 3839 26 liver liver NN cord-028721-x6f26ahr 3839 27 insuffi insuffi NNP cord-028721-x6f26ahr 3839 28 ciency ciency NNP cord-028721-x6f26ahr 3839 29 . . . cord-028721-x6f26ahr 3840 1 Another another DT cord-028721-x6f26ahr 3840 2 possible possible JJ cord-028721-x6f26ahr 3840 3 cause cause NN cord-028721-x6f26ahr 3840 4 is be VBZ cord-028721-x6f26ahr 3840 5 infl infl NN cord-028721-x6f26ahr 3840 6 ammation ammation NN cord-028721-x6f26ahr 3840 7 involving involve VBG cord-028721-x6f26ahr 3840 8 the the DT cord-028721-x6f26ahr 3840 9 rete rete NN cord-028721-x6f26ahr 3840 10 testis testis NN cord-028721-x6f26ahr 3840 11 . . . cord-028721-x6f26ahr 3841 1 Cystic cystic JJ cord-028721-x6f26ahr 3841 2 transformation transformation NN cord-028721-x6f26ahr 3841 3 with with IN cord-028721-x6f26ahr 3841 4 crystalline crystalline JJ cord-028721-x6f26ahr 3841 5 deposits deposit NNS cord-028721-x6f26ahr 3841 6 has have VBZ cord-028721-x6f26ahr 3841 7 also also RB cord-028721-x6f26ahr 3841 8 been be VBN cord-028721-x6f26ahr 3841 9 called call VBN cord-028721-x6f26ahr 3841 10 cystic cystic JJ cord-028721-x6f26ahr 3841 11 transformation transformation NN cord-028721-x6f26ahr 3841 12 of of IN cord-028721-x6f26ahr 3841 13 the the DT cord-028721-x6f26ahr 3841 14 rete rete NN cord-028721-x6f26ahr 3841 15 testis testis NN cord-028721-x6f26ahr 3841 16 secondary secondary JJ cord-028721-x6f26ahr 3841 17 to to IN cord-028721-x6f26ahr 3841 18 renal renal JJ cord-028721-x6f26ahr 3841 19 insuffi insuffi NNP cord-028721-x6f26ahr 3841 20 ciency ciency NN cord-028721-x6f26ahr 3841 21 . . . cord-028721-x6f26ahr 3842 1 1642 1642 CD cord-028721-x6f26ahr 3843 1 It -PRON- PRP cord-028721-x6f26ahr 3843 2 is be VBZ cord-028721-x6f26ahr 3843 3 a a DT cord-028721-x6f26ahr 3843 4 bilateral bilateral JJ cord-028721-x6f26ahr 3843 5 lesion lesion NN cord-028721-x6f26ahr 3843 6 of of IN cord-028721-x6f26ahr 3843 7 adult adult NN cord-028721-x6f26ahr 3843 8 testes testis NNS cord-028721-x6f26ahr 3843 9 characterized characterize VBN cord-028721-x6f26ahr 3843 10 by by IN cord-028721-x6f26ahr 3843 11 the the DT cord-028721-x6f26ahr 3843 12 concurrence concurrence NN cord-028721-x6f26ahr 3843 13 of of IN cord-028721-x6f26ahr 3843 14 three three CD cord-028721-x6f26ahr 3843 15 fi fi NNP cord-028721-x6f26ahr 3843 16 ndings nding NNS cord-028721-x6f26ahr 3843 17 : : : cord-028721-x6f26ahr 3843 18 cystic cystic JJ cord-028721-x6f26ahr 3843 19 transformation transformation NN cord-028721-x6f26ahr 3843 20 of of IN cord-028721-x6f26ahr 3843 21 the the DT cord-028721-x6f26ahr 3843 22 rete rete NN cord-028721-x6f26ahr 3843 23 testis testis NN cord-028721-x6f26ahr 3843 24 , , , cord-028721-x6f26ahr 3843 25 cuboidal cuboidal JJ cord-028721-x6f26ahr 3843 26 or or CC cord-028721-x6f26ahr 3843 27 columnar columnar JJ cord-028721-x6f26ahr 3843 28 metaplasia metaplasia NN cord-028721-x6f26ahr 3843 29 of of IN cord-028721-x6f26ahr 3843 30 its -PRON- PRP$ cord-028721-x6f26ahr 3843 31 epithelium epithelium NN cord-028721-x6f26ahr 3843 32 , , , cord-028721-x6f26ahr 3843 33 and and CC cord-028721-x6f26ahr 3843 34 the the DT cord-028721-x6f26ahr 3843 35 presence presence NN cord-028721-x6f26ahr 3843 36 of of IN cord-028721-x6f26ahr 3843 37 urate urate NN cord-028721-x6f26ahr 3843 38 and and CC cord-028721-x6f26ahr 3843 39 oxalate oxalate NN cord-028721-x6f26ahr 3843 40 crystalline crystalline NN cord-028721-x6f26ahr 3843 41 deposits deposit NNS cord-028721-x6f26ahr 3843 42 that that WDT cord-028721-x6f26ahr 3843 43 may may MD cord-028721-x6f26ahr 3843 44 be be VB cord-028721-x6f26ahr 3843 45 recognized recognize VBN cord-028721-x6f26ahr 3843 46 by by IN cord-028721-x6f26ahr 3843 47 polarized polarized JJ cord-028721-x6f26ahr 3843 48 light light NN cord-028721-x6f26ahr 3843 49 . . . cord-028721-x6f26ahr 3844 1 The the DT cord-028721-x6f26ahr 3844 2 lesion lesion NN cord-028721-x6f26ahr 3844 3 is be VBZ cord-028721-x6f26ahr 3844 4 pathognomonic pathognomonic JJ cord-028721-x6f26ahr 3844 5 of of IN cord-028721-x6f26ahr 3844 6 dialyzed dialyzed JJ cord-028721-x6f26ahr 3844 7 patients patient NNS cord-028721-x6f26ahr 3844 8 with with IN cord-028721-x6f26ahr 3844 9 chronic chronic JJ cord-028721-x6f26ahr 3844 10 renal renal JJ cord-028721-x6f26ahr 3844 11 insuffi insuffi NN cord-028721-x6f26ahr 3844 12 ciency ciency NN cord-028721-x6f26ahr 3844 13 . . . cord-028721-x6f26ahr 3845 1 Crystalline crystalline JJ cord-028721-x6f26ahr 3845 2 deposits deposit NNS cord-028721-x6f26ahr 3845 3 are be VBP cord-028721-x6f26ahr 3845 4 initially initially RB cord-028721-x6f26ahr 3845 5 formed form VBN cord-028721-x6f26ahr 3845 6 beneath beneath IN cord-028721-x6f26ahr 3845 7 the the DT cord-028721-x6f26ahr 3845 8 epithelia epithelium NNS cord-028721-x6f26ahr 3845 9 of of IN cord-028721-x6f26ahr 3845 10 the the DT cord-028721-x6f26ahr 3845 11 rete rete NN cord-028721-x6f26ahr 3845 12 testis testis NN cord-028721-x6f26ahr 3845 13 and and CC cord-028721-x6f26ahr 3845 14 ductuli ductuli NNP cord-028721-x6f26ahr 3845 15 efferentes efferentes NNPS cord-028721-x6f26ahr 3845 16 ; ; : cord-028721-x6f26ahr 3845 17 later later RB cord-028721-x6f26ahr 3845 18 they -PRON- PRP cord-028721-x6f26ahr 3845 19 protrude protrude VBP cord-028721-x6f26ahr 3845 20 into into IN cord-028721-x6f26ahr 3845 21 the the DT cord-028721-x6f26ahr 3845 22 lumina lumina NNP cord-028721-x6f26ahr 3845 23 , , , cord-028721-x6f26ahr 3845 24 where where WRB cord-028721-x6f26ahr 3845 25 they -PRON- PRP cord-028721-x6f26ahr 3845 26 are be VBP cord-028721-x6f26ahr 3845 27 fi fi NNP cord-028721-x6f26ahr 3845 28 nally nally RB cord-028721-x6f26ahr 3845 29 released release VBN cord-028721-x6f26ahr 3845 30 . . . cord-028721-x6f26ahr 3846 1 Infl Infl NNP cord-028721-x6f26ahr 3846 2 ammation ammation NNP cord-028721-x6f26ahr 3846 3 is be VBZ cord-028721-x6f26ahr 3846 4 absent absent JJ cord-028721-x6f26ahr 3846 5 or or CC cord-028721-x6f26ahr 3846 6 slight slight JJ cord-028721-x6f26ahr 3846 7 , , , cord-028721-x6f26ahr 3846 8 although although IN cord-028721-x6f26ahr 3846 9 a a DT cord-028721-x6f26ahr 3846 10 few few JJ cord-028721-x6f26ahr 3846 11 giant giant JJ cord-028721-x6f26ahr 3846 12 cells cell NNS cord-028721-x6f26ahr 3846 13 and and CC cord-028721-x6f26ahr 3846 14 small small JJ cord-028721-x6f26ahr 3846 15 fi fi NN cord-028721-x6f26ahr 3846 16 brotic brotic NN cord-028721-x6f26ahr 3846 17 areas area NNS cord-028721-x6f26ahr 3846 18 are be VBP cord-028721-x6f26ahr 3846 19 often often RB cord-028721-x6f26ahr 3846 20 seen see VBN cord-028721-x6f26ahr 3846 21 ( ( -LRB- cord-028721-x6f26ahr 3846 22 Figs Figs NNP cord-028721-x6f26ahr 3846 23 12 12 CD cord-028721-x6f26ahr 3846 24 - - SYM cord-028721-x6f26ahr 3846 25 171 171 CD cord-028721-x6f26ahr 3846 26 , , , cord-028721-x6f26ahr 3846 27 12 12 CD cord-028721-x6f26ahr 3846 28 - - SYM cord-028721-x6f26ahr 3846 29 172 172 CD cord-028721-x6f26ahr 3846 30 ) ) -RRB- cord-028721-x6f26ahr 3846 31 . . . cord-028721-x6f26ahr 3847 1 This this DT cord-028721-x6f26ahr 3847 2 lesion lesion NN cord-028721-x6f26ahr 3847 3 is be VBZ cord-028721-x6f26ahr 3847 4 characterized characterize VBN cord-028721-x6f26ahr 3847 5 by by IN cord-028721-x6f26ahr 3847 6 diffuse diffuse JJ cord-028721-x6f26ahr 3847 7 or or CC cord-028721-x6f26ahr 3847 8 nodular nodular JJ cord-028721-x6f26ahr 3847 9 proliferation proliferation NN cord-028721-x6f26ahr 3847 10 of of IN cord-028721-x6f26ahr 3847 11 tubular tubular JJ cord-028721-x6f26ahr 3847 12 or or CC cord-028721-x6f26ahr 3847 13 papillary papillary JJ cord-028721-x6f26ahr 3847 14 structures structure NNS cord-028721-x6f26ahr 3847 15 that that WDT cord-028721-x6f26ahr 3847 16 are be VBP cord-028721-x6f26ahr 3847 17 derived derive VBN cord-028721-x6f26ahr 3847 18 from from IN cord-028721-x6f26ahr 3847 19 the the DT cord-028721-x6f26ahr 3847 20 rete rete NN cord-028721-x6f26ahr 3847 21 testis testis NN cord-028721-x6f26ahr 3847 22 1643 1643 CD cord-028721-x6f26ahr 3847 23 and and CC cord-028721-x6f26ahr 3847 24 are be VBP cord-028721-x6f26ahr 3847 25 observed observe VBN cord-028721-x6f26ahr 3847 26 in in IN cord-028721-x6f26ahr 3847 27 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3847 28 or or CC cord-028721-x6f26ahr 3847 29 normally normally RB cord-028721-x6f26ahr 3847 30 descended descend VBN cord-028721-x6f26ahr 3847 31 testes testis NNS cord-028721-x6f26ahr 3847 32 . . . cord-028721-x6f26ahr 3848 1 Cases case NNS cord-028721-x6f26ahr 3848 2 have have VBP cord-028721-x6f26ahr 3848 3 been be VBN cord-028721-x6f26ahr 3848 4 reported report VBN cord-028721-x6f26ahr 3848 5 in in IN cord-028721-x6f26ahr 3848 6 newborns newborn NNS cord-028721-x6f26ahr 3848 7 , , , cord-028721-x6f26ahr 3848 8 children child NNS cord-028721-x6f26ahr 3848 9 , , , cord-028721-x6f26ahr 3848 10 and and CC cord-028721-x6f26ahr 3848 11 adults adult NNS cord-028721-x6f26ahr 3848 12 . . . cord-028721-x6f26ahr 3849 1 1644 1644 CD cord-028721-x6f26ahr 3849 2 Adenomatous adenomatous JJ cord-028721-x6f26ahr 3849 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3849 4 in in IN cord-028721-x6f26ahr 3849 5 newborn newborn JJ cord-028721-x6f26ahr 3849 6 and and CC cord-028721-x6f26ahr 3849 7 infantile infantile JJ cord-028721-x6f26ahr 3849 8 testes testis NNS cord-028721-x6f26ahr 3849 9 consists consist VBZ cord-028721-x6f26ahr 3849 10 of of IN cord-028721-x6f26ahr 3849 11 enlargement enlargement NN cord-028721-x6f26ahr 3849 12 of of IN cord-028721-x6f26ahr 3849 13 the the DT cord-028721-x6f26ahr 3849 14 mediastinum mediastinum NN cord-028721-x6f26ahr 3849 15 testis testis NN cord-028721-x6f26ahr 3849 16 by by IN cord-028721-x6f26ahr 3849 17 cordlike cordlike NN cord-028721-x6f26ahr 3849 18 or or CC cord-028721-x6f26ahr 3849 19 tubular tubular JJ cord-028721-x6f26ahr 3849 20 structures structure NNS cord-028721-x6f26ahr 3849 21 derived derive VBN cord-028721-x6f26ahr 3849 22 from from IN cord-028721-x6f26ahr 3849 23 the the DT cord-028721-x6f26ahr 3849 24 rete rete NN cord-028721-x6f26ahr 3849 25 testis testis NN cord-028721-x6f26ahr 3849 26 . . . cord-028721-x6f26ahr 3850 1 The the DT cord-028721-x6f26ahr 3850 2 lesion lesion NN cord-028721-x6f26ahr 3850 3 may may MD cord-028721-x6f26ahr 3850 4 extend extend VB cord-028721-x6f26ahr 3850 5 up up IN cord-028721-x6f26ahr 3850 6 to to IN cord-028721-x6f26ahr 3850 7 one one CD cord-028721-x6f26ahr 3850 8 - - HYPH cord-028721-x6f26ahr 3850 9 third third NN cord-028721-x6f26ahr 3850 10 of of IN cord-028721-x6f26ahr 3850 11 testicular testicular JJ cord-028721-x6f26ahr 3850 12 volume volume NN cord-028721-x6f26ahr 3850 13 . . . cord-028721-x6f26ahr 3851 1 Despite despite IN cord-028721-x6f26ahr 3851 2 excessive excessive JJ cord-028721-x6f26ahr 3851 3 development development NN cord-028721-x6f26ahr 3851 4 of of IN cord-028721-x6f26ahr 3851 5 the the DT cord-028721-x6f26ahr 3851 6 rete rete NNP cord-028721-x6f26ahr 3851 7 testis testis NN cord-028721-x6f26ahr 3851 8 , , , cord-028721-x6f26ahr 3851 9 the the DT cord-028721-x6f26ahr 3851 10 normal normal JJ cord-028721-x6f26ahr 3851 11 connections connection NNS cord-028721-x6f26ahr 3851 12 with with IN cord-028721-x6f26ahr 3851 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 3851 14 tubules tubule NNS cord-028721-x6f26ahr 3851 15 and and CC cord-028721-x6f26ahr 3851 16 efferent efferent JJ cord-028721-x6f26ahr 3851 17 ductuli ductuli NNS cord-028721-x6f26ahr 3851 18 remain remain VBP cord-028721-x6f26ahr 3851 19 . . . cord-028721-x6f26ahr 3852 1 Presentation presentation NN cord-028721-x6f26ahr 3852 2 may may MD cord-028721-x6f26ahr 3852 3 be be VB cord-028721-x6f26ahr 3852 4 unilateral unilateral JJ cord-028721-x6f26ahr 3852 5 or or CC cord-028721-x6f26ahr 3852 6 bilateral bilateral JJ cord-028721-x6f26ahr 3852 7 . . . cord-028721-x6f26ahr 3853 1 Unilateral unilateral JJ cord-028721-x6f26ahr 3853 2 presentation presentation NN cord-028721-x6f26ahr 3853 3 is be VBZ cord-028721-x6f26ahr 3853 4 associated associate VBN cord-028721-x6f26ahr 3853 5 with with IN cord-028721-x6f26ahr 3853 6 cryptorchidism cryptorchidism NNS cord-028721-x6f26ahr 3853 7 or or CC cord-028721-x6f26ahr 3853 8 vanishing vanish VBG cord-028721-x6f26ahr 3853 9 testis testis NN cord-028721-x6f26ahr 3853 10 . . . cord-028721-x6f26ahr 3854 1 Bilateral bilateral JJ cord-028721-x6f26ahr 3854 2 cases case NNS cord-028721-x6f26ahr 3854 3 may may MD cord-028721-x6f26ahr 3854 4 also also RB cord-028721-x6f26ahr 3854 5 present present VB cord-028721-x6f26ahr 3854 6 with with IN cord-028721-x6f26ahr 3854 7 bilateral bilateral JJ cord-028721-x6f26ahr 3854 8 renal renal JJ cord-028721-x6f26ahr 3854 9 dysplasia dysplasia NN cord-028721-x6f26ahr 3854 10 . . . cord-028721-x6f26ahr 3855 1 Efferent Efferent NNP cord-028721-x6f26ahr 3855 2 ductuli ductuli NN cord-028721-x6f26ahr 3855 3 may may MD cord-028721-x6f26ahr 3855 4 show show VB cord-028721-x6f26ahr 3855 5 luminal luminal JJ cord-028721-x6f26ahr 3855 6 dilation dilation NN cord-028721-x6f26ahr 3855 7 and and CC cord-028721-x6f26ahr 3855 8 irregular irregular JJ cord-028721-x6f26ahr 3855 9 outlines outline NNS cord-028721-x6f26ahr 3855 10 . . . cord-028721-x6f26ahr 3856 1 The the DT cord-028721-x6f26ahr 3856 2 etiopathogenesis etiopathogenesis NN cord-028721-x6f26ahr 3856 3 might may MD cord-028721-x6f26ahr 3856 4 be be VB cord-028721-x6f26ahr 3856 5 similar similar JJ cord-028721-x6f26ahr 3856 6 to to IN cord-028721-x6f26ahr 3856 7 that that DT cord-028721-x6f26ahr 3856 8 of of IN cord-028721-x6f26ahr 3856 9 cystic cystic JJ cord-028721-x6f26ahr 3856 10 dysplasia dysplasia NN cord-028721-x6f26ahr 3856 11 of of IN cord-028721-x6f26ahr 3856 12 the the DT cord-028721-x6f26ahr 3856 13 testis testis NN cord-028721-x6f26ahr 3856 14 . . . cord-028721-x6f26ahr 3857 1 1644 1644 CD cord-028721-x6f26ahr 3857 2 Adenomatous adenomatous JJ cord-028721-x6f26ahr 3857 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3857 4 in in IN cord-028721-x6f26ahr 3857 5 adults adult NNS cord-028721-x6f26ahr 3857 6 is be VBZ cord-028721-x6f26ahr 3857 7 usually usually RB cord-028721-x6f26ahr 3857 8 an an DT cord-028721-x6f26ahr 3857 9 incidental incidental JJ cord-028721-x6f26ahr 3857 10 fi fi NN cord-028721-x6f26ahr 3857 11 nding nding NN cord-028721-x6f26ahr 3857 12 at at IN cord-028721-x6f26ahr 3857 13 autopsy autopsy NN cord-028721-x6f26ahr 3857 14 , , , cord-028721-x6f26ahr 3857 15 1645 1645 CD cord-028721-x6f26ahr 3857 16 in in IN cord-028721-x6f26ahr 3857 17 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3857 18 testes testis NNS cord-028721-x6f26ahr 3857 19 , , , cord-028721-x6f26ahr 3857 20 1646 1646 CD cord-028721-x6f26ahr 3857 21 or or CC cord-028721-x6f26ahr 3857 22 in in IN cord-028721-x6f26ahr 3857 23 testes testis NNS cord-028721-x6f26ahr 3857 24 with with IN cord-028721-x6f26ahr 3857 25 germ germ NN cord-028721-x6f26ahr 3857 26 cell cell NN cord-028721-x6f26ahr 3857 27 tumor tumor NN cord-028721-x6f26ahr 3857 28 . . . cord-028721-x6f26ahr 3858 1 The the DT cord-028721-x6f26ahr 3858 2 rete rete NN cord-028721-x6f26ahr 3858 3 testis testis NN cord-028721-x6f26ahr 3858 4 epithelium epithelium NN cord-028721-x6f26ahr 3858 5 forms form NNS cord-028721-x6f26ahr 3858 6 nonencapsulated nonencapsulate VBN cord-028721-x6f26ahr 3858 7 nodular nodular JJ cord-028721-x6f26ahr 3858 8 outgrowths outgrowth NNS cord-028721-x6f26ahr 3858 9 or or CC cord-028721-x6f26ahr 3858 10 a a DT cord-028721-x6f26ahr 3858 11 diffuse diffuse JJ cord-028721-x6f26ahr 3858 12 pattern pattern NN cord-028721-x6f26ahr 3858 13 . . . cord-028721-x6f26ahr 3859 1 Nodule nodule NN cord-028721-x6f26ahr 3859 2 size size NN cord-028721-x6f26ahr 3859 3 may may MD cord-028721-x6f26ahr 3859 4 be be VB cord-028721-x6f26ahr 3859 5 large large JJ cord-028721-x6f26ahr 3859 6 enough enough RB cord-028721-x6f26ahr 3859 7 to to TO cord-028721-x6f26ahr 3859 8 suggest suggest VB cord-028721-x6f26ahr 3859 9 tumor tumor NN cord-028721-x6f26ahr 3859 10 . . . cord-028721-x6f26ahr 3860 1 The the DT cord-028721-x6f26ahr 3860 2 epithelium epithelium NN cord-028721-x6f26ahr 3860 3 consists consist VBZ cord-028721-x6f26ahr 3860 4 of of IN cord-028721-x6f26ahr 3860 5 cuboidal cuboidal JJ cord-028721-x6f26ahr 3860 6 cells cell NNS cord-028721-x6f26ahr 3860 7 with with IN cord-028721-x6f26ahr 3860 8 ovoid ovoid JJ cord-028721-x6f26ahr 3860 9 nuclei nucleus NNS cord-028721-x6f26ahr 3860 10 , , , cord-028721-x6f26ahr 3860 11 deep deep JJ cord-028721-x6f26ahr 3860 12 nuclear nuclear JJ cord-028721-x6f26ahr 3860 13 folds fold NNS cord-028721-x6f26ahr 3860 14 , , , cord-028721-x6f26ahr 3860 15 and and CC cord-028721-x6f26ahr 3860 16 peripheral peripheral JJ cord-028721-x6f26ahr 3860 17 nucleoli nucleolus NNS cord-028721-x6f26ahr 3860 18 . . . cord-028721-x6f26ahr 3861 1 Atypias Atypias NNP cord-028721-x6f26ahr 3861 2 and and CC cord-028721-x6f26ahr 3861 3 mitotic mitotic JJ cord-028721-x6f26ahr 3861 4 fi fi NN cord-028721-x6f26ahr 3861 5 gures gure NNS cord-028721-x6f26ahr 3861 6 are be VBP cord-028721-x6f26ahr 3861 7 lacking lack VBG cord-028721-x6f26ahr 3861 8 ( ( -LRB- cord-028721-x6f26ahr 3861 9 Fig Fig NNP cord-028721-x6f26ahr 3861 10 . . . cord-028721-x6f26ahr 3861 11 12 12 CD cord-028721-x6f26ahr 3861 12 - - SYM cord-028721-x6f26ahr 3861 13 173 173 CD cord-028721-x6f26ahr 3861 14 ) ) -RRB- cord-028721-x6f26ahr 3861 15 . . . cord-028721-x6f26ahr 3862 1 The the DT cord-028721-x6f26ahr 3862 2 ultrastructure ultrastructure NN cord-028721-x6f26ahr 3862 3 and and CC cord-028721-x6f26ahr 3862 4 immunophenotype immunophenotype NN cord-028721-x6f26ahr 3862 5 of of IN cord-028721-x6f26ahr 3862 6 the the DT cord-028721-x6f26ahr 3862 7 epithelium epithelium NN cord-028721-x6f26ahr 3862 8 are be VBP cord-028721-x6f26ahr 3862 9 similar similar JJ cord-028721-x6f26ahr 3862 10 to to IN cord-028721-x6f26ahr 3862 11 those those DT cord-028721-x6f26ahr 3862 12 of of IN cord-028721-x6f26ahr 3862 13 the the DT cord-028721-x6f26ahr 3862 14 normal normal JJ cord-028721-x6f26ahr 3862 15 rete rete NN cord-028721-x6f26ahr 3862 16 testis testis NN cord-028721-x6f26ahr 3862 17 . . . cord-028721-x6f26ahr 3863 1 Spermatozoa Spermatozoa NNP cord-028721-x6f26ahr 3863 2 may may MD cord-028721-x6f26ahr 3863 3 be be VB cord-028721-x6f26ahr 3863 4 seen see VBN cord-028721-x6f26ahr 3863 5 inside inside IN cord-028721-x6f26ahr 3863 6 the the DT cord-028721-x6f26ahr 3863 7 cavities cavity NNS cord-028721-x6f26ahr 3863 8 in in IN cord-028721-x6f26ahr 3863 9 some some DT cord-028721-x6f26ahr 3863 10 cases case NNS cord-028721-x6f26ahr 3863 11 , , , cord-028721-x6f26ahr 3863 12 suggesting suggest VBG cord-028721-x6f26ahr 3863 13 that that IN cord-028721-x6f26ahr 3863 14 such such PDT cord-028721-x6f26ahr 3863 15 a a DT cord-028721-x6f26ahr 3863 16 proliferation proliferation NN cord-028721-x6f26ahr 3863 17 is be VBZ cord-028721-x6f26ahr 3863 18 connected connect VBN cord-028721-x6f26ahr 3863 19 with with IN cord-028721-x6f26ahr 3863 20 the the DT cord-028721-x6f26ahr 3863 21 seminiferous seminiferous JJ cord-028721-x6f26ahr 3863 22 tubules tubule NNS cord-028721-x6f26ahr 3863 23 . . . cord-028721-x6f26ahr 3864 1 Most Most JJS cord-028721-x6f26ahr 3864 2 of of IN cord-028721-x6f26ahr 3864 3 the the DT cord-028721-x6f26ahr 3864 4 testes testis NNS cord-028721-x6f26ahr 3864 5 show show VBP cord-028721-x6f26ahr 3864 6 a a DT cord-028721-x6f26ahr 3864 7 certain certain JJ cord-028721-x6f26ahr 3864 8 degree degree NN cord-028721-x6f26ahr 3864 9 of of IN cord-028721-x6f26ahr 3864 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 3864 11 tubular tubular JJ cord-028721-x6f26ahr 3864 12 atrophy atrophy NN cord-028721-x6f26ahr 3864 13 . . . cord-028721-x6f26ahr 3865 1 In in IN cord-028721-x6f26ahr 3865 2 incidental incidental JJ cord-028721-x6f26ahr 3865 3 autopsy autopsy JJ cord-028721-x6f26ahr 3865 4 cases case NNS cord-028721-x6f26ahr 3865 5 the the DT cord-028721-x6f26ahr 3865 6 etiology etiology NN cord-028721-x6f26ahr 3865 7 is be VBZ cord-028721-x6f26ahr 3865 8 unknown unknown JJ cord-028721-x6f26ahr 3865 9 , , , cord-028721-x6f26ahr 3865 10 although although IN cord-028721-x6f26ahr 3865 11 it -PRON- PRP cord-028721-x6f26ahr 3865 12 may may MD cord-028721-x6f26ahr 3865 13 be be VB cord-028721-x6f26ahr 3865 14 related relate VBN cord-028721-x6f26ahr 3865 15 to to IN cord-028721-x6f26ahr 3865 16 hormonal hormonal JJ cord-028721-x6f26ahr 3865 17 or or CC cord-028721-x6f26ahr 3865 18 chemical chemical JJ cord-028721-x6f26ahr 3865 19 agent agent NN cord-028721-x6f26ahr 3865 20 effects effect NNS cord-028721-x6f26ahr 3865 21 . . . cord-028721-x6f26ahr 3866 1 [ [ -LRB- cord-028721-x6f26ahr 3866 2 1647 1647 CD cord-028721-x6f26ahr 3866 3 ] ] -RRB- cord-028721-x6f26ahr 3866 4 [ [ -LRB- cord-028721-x6f26ahr 3866 5 1648 1648 CD cord-028721-x6f26ahr 3866 6 ] ] -RRB- cord-028721-x6f26ahr 3866 7 [ [ -LRB- cord-028721-x6f26ahr 3866 8 1649 1649 CD cord-028721-x6f26ahr 3866 9 ] ] -RRB- cord-028721-x6f26ahr 3867 1 In in IN cord-028721-x6f26ahr 3867 2 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3867 3 testes testis NNS cord-028721-x6f26ahr 3867 4 and and CC cord-028721-x6f26ahr 3867 5 with with IN cord-028721-x6f26ahr 3867 6 many many JJ cord-028721-x6f26ahr 3867 7 testicular testicular JJ cord-028721-x6f26ahr 3867 8 tumors tumor NNS cord-028721-x6f26ahr 3867 9 , , , cord-028721-x6f26ahr 3867 10 the the DT cord-028721-x6f26ahr 3867 11 most most RBS cord-028721-x6f26ahr 3867 12 probable probable JJ cord-028721-x6f26ahr 3867 13 cause cause NN cord-028721-x6f26ahr 3867 14 is be VBZ cord-028721-x6f26ahr 3867 15 a a DT cord-028721-x6f26ahr 3867 16 primary primary JJ cord-028721-x6f26ahr 3867 17 anomaly anomaly NN cord-028721-x6f26ahr 3867 18 that that WDT cord-028721-x6f26ahr 3867 19 is be VBZ cord-028721-x6f26ahr 3867 20 part part NN cord-028721-x6f26ahr 3867 21 of of IN cord-028721-x6f26ahr 3867 22 the the DT cord-028721-x6f26ahr 3867 23 testicular testicular NNP cord-028721-x6f26ahr 3867 24 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 3867 25 syndrome syndrome NN cord-028721-x6f26ahr 3867 26 . . . cord-028721-x6f26ahr 3868 1 1650 1650 CD cord-028721-x6f26ahr 3868 2 Adenomatous adenomatous JJ cord-028721-x6f26ahr 3868 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3868 4 should should MD cord-028721-x6f26ahr 3868 5 be be VB cord-028721-x6f26ahr 3868 6 distinguished distinguish VBN cord-028721-x6f26ahr 3868 7 from from IN cord-028721-x6f26ahr 3868 8 three three CD cord-028721-x6f26ahr 3868 9 entities entity NNS cord-028721-x6f26ahr 3868 10 : : : cord-028721-x6f26ahr 3868 11 rete rete NNP cord-028721-x6f26ahr 3868 12 testis testis NN cord-028721-x6f26ahr 3868 13 pseudohyperplasia pseudohyperplasia NNP cord-028721-x6f26ahr 3868 14 , , , cord-028721-x6f26ahr 3868 15 which which WDT cord-028721-x6f26ahr 3868 16 appears appear VBZ cord-028721-x6f26ahr 3868 17 in in IN cord-028721-x6f26ahr 3868 18 atrophic atrophic JJ cord-028721-x6f26ahr 3868 19 testes testis NNS cord-028721-x6f26ahr 3868 20 ; ; : cord-028721-x6f26ahr 3868 21 primary primary JJ cord-028721-x6f26ahr 3868 22 rete rete NN cord-028721-x6f26ahr 3868 23 testis testis NN cord-028721-x6f26ahr 3868 24 tumor tumor NN cord-028721-x6f26ahr 3868 25 ; ; : cord-028721-x6f26ahr 3868 26 and and CC cord-028721-x6f26ahr 3868 27 metastasis metastasis NN cord-028721-x6f26ahr 3868 28 of of IN cord-028721-x6f26ahr 3868 29 adenocarcinoma adenocarcinoma NN cord-028721-x6f26ahr 3868 30 . . . cord-028721-x6f26ahr 3869 1 In in IN cord-028721-x6f26ahr 3869 2 pseudohyperplasia pseudohyperplasia NNS cord-028721-x6f26ahr 3869 3 , , , cord-028721-x6f26ahr 3869 4 lesions lesion NNS cord-028721-x6f26ahr 3869 5 are be VBP cord-028721-x6f26ahr 3869 6 focal focal JJ cord-028721-x6f26ahr 3869 7 , , , cord-028721-x6f26ahr 3869 8 microscopic microscopic JJ cord-028721-x6f26ahr 3869 9 , , , cord-028721-x6f26ahr 3869 10 and and CC cord-028721-x6f26ahr 3869 11 usually usually RB cord-028721-x6f26ahr 3869 12 located locate VBN cord-028721-x6f26ahr 3869 13 in in IN cord-028721-x6f26ahr 3869 14 the the DT cord-028721-x6f26ahr 3869 15 septal septal JJ cord-028721-x6f26ahr 3869 16 rete rete NN cord-028721-x6f26ahr 3869 17 , , , cord-028721-x6f26ahr 3869 18 although although IN cord-028721-x6f26ahr 3869 19 the the DT cord-028721-x6f26ahr 3869 20 mediastinal mediastinal JJ cord-028721-x6f26ahr 3869 21 rete rete NN cord-028721-x6f26ahr 3869 22 shows show VBZ cord-028721-x6f26ahr 3869 23 few few JJ cord-028721-x6f26ahr 3869 24 or or CC cord-028721-x6f26ahr 3869 25 no no DT cord-028721-x6f26ahr 3869 26 alterations alteration NNS cord-028721-x6f26ahr 3869 27 . . . cord-028721-x6f26ahr 3870 1 Benign benign JJ cord-028721-x6f26ahr 3870 2 rete rete NN cord-028721-x6f26ahr 3870 3 testis testis NN cord-028721-x6f26ahr 3870 4 tumor tumor NN cord-028721-x6f26ahr 3870 5 such such JJ cord-028721-x6f26ahr 3870 6 as as IN cord-028721-x6f26ahr 3870 7 adenoma adenoma NN cord-028721-x6f26ahr 3870 8 ( ( -LRB- cord-028721-x6f26ahr 3870 9 solid solid JJ cord-028721-x6f26ahr 3870 10 and and CC cord-028721-x6f26ahr 3870 11 papillary papillary JJ cord-028721-x6f26ahr 3870 12 variants variant NNS cord-028721-x6f26ahr 3870 13 ) ) -RRB- cord-028721-x6f26ahr 3871 1 Fig Fig NNP cord-028721-x6f26ahr 3871 2 . . . cord-028721-x6f26ahr 3872 1 12 12 CD cord-028721-x6f26ahr 3872 2 - - SYM cord-028721-x6f26ahr 3872 3 171 171 CD cord-028721-x6f26ahr 3872 4 Changes change NNS cord-028721-x6f26ahr 3872 5 in in IN cord-028721-x6f26ahr 3872 6 the the DT cord-028721-x6f26ahr 3872 7 rete rete NN cord-028721-x6f26ahr 3872 8 testis testis NN cord-028721-x6f26ahr 3872 9 associated associate VBN cord-028721-x6f26ahr 3872 10 with with IN cord-028721-x6f26ahr 3872 11 dialysis dialysis NN cord-028721-x6f26ahr 3872 12 . . . cord-028721-x6f26ahr 3873 1 Dilation dilation NN cord-028721-x6f26ahr 3873 2 of of IN cord-028721-x6f26ahr 3873 3 the the DT cord-028721-x6f26ahr 3873 4 rete rete NN cord-028721-x6f26ahr 3873 5 testis testis NN cord-028721-x6f26ahr 3873 6 and and CC cord-028721-x6f26ahr 3873 7 initial initial JJ cord-028721-x6f26ahr 3873 8 portion portion NN cord-028721-x6f26ahr 3873 9 of of IN cord-028721-x6f26ahr 3873 10 the the DT cord-028721-x6f26ahr 3873 11 ductuli ductuli NNP cord-028721-x6f26ahr 3873 12 efferentes efferentes NNPS cord-028721-x6f26ahr 3873 13 can can MD cord-028721-x6f26ahr 3873 14 be be VB cord-028721-x6f26ahr 3873 15 observed observe VBN cord-028721-x6f26ahr 3873 16 . . . cord-028721-x6f26ahr 3874 1 Crystalline crystalline JJ cord-028721-x6f26ahr 3874 2 structures structure NNS cord-028721-x6f26ahr 3874 3 , , , cord-028721-x6f26ahr 3874 4 mainly mainly RB cord-028721-x6f26ahr 3874 5 rhomboidal rhomboidal JJ cord-028721-x6f26ahr 3874 6 in in IN cord-028721-x6f26ahr 3874 7 shape shape NN cord-028721-x6f26ahr 3874 8 , , , cord-028721-x6f26ahr 3874 9 accumulate accumulate VBP cord-028721-x6f26ahr 3874 10 inside inside IN cord-028721-x6f26ahr 3874 11 and and CC cord-028721-x6f26ahr 3874 12 outside outside IN cord-028721-x6f26ahr 3874 13 the the DT cord-028721-x6f26ahr 3874 14 tubules tubule NNS cord-028721-x6f26ahr 3874 15 . . . cord-028721-x6f26ahr 3875 1 Other other JJ cord-028721-x6f26ahr 3875 2 testicular testicular JJ cord-028721-x6f26ahr 3875 3 diseases disease NNS cord-028721-x6f26ahr 3875 4 and and CC cord-028721-x6f26ahr 3875 5 cystoadenoma cystoadenoma NNP cord-028721-x6f26ahr 3875 6 are be VBP cord-028721-x6f26ahr 3875 7 isolated isolate VBN cord-028721-x6f26ahr 3875 8 and and CC cord-028721-x6f26ahr 3875 9 focal focal JJ cord-028721-x6f26ahr 3875 10 , , , cord-028721-x6f26ahr 3875 11 1651 1651 CD cord-028721-x6f26ahr 3875 12 whereas whereas IN cord-028721-x6f26ahr 3875 13 rete rete NNP cord-028721-x6f26ahr 3875 14 testis testis NN cord-028721-x6f26ahr 3875 15 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3875 16 is be VBZ cord-028721-x6f26ahr 3875 17 diffuse diffuse JJ cord-028721-x6f26ahr 3875 18 . . . cord-028721-x6f26ahr 3876 1 Adenocarcinoma Adenocarcinoma NNP cord-028721-x6f26ahr 3876 2 of of IN cord-028721-x6f26ahr 3876 3 the the DT cord-028721-x6f26ahr 3876 4 rete rete NN cord-028721-x6f26ahr 3876 5 testis testis NN cord-028721-x6f26ahr 3876 6 is be VBZ cord-028721-x6f26ahr 3876 7 a a DT cord-028721-x6f26ahr 3876 8 tumor tumor NN cord-028721-x6f26ahr 3876 9 that that WDT cord-028721-x6f26ahr 3876 10 displays display VBZ cord-028721-x6f26ahr 3876 11 numerous numerous JJ cord-028721-x6f26ahr 3876 12 mitotic mitotic JJ cord-028721-x6f26ahr 3876 13 fi fi NN cord-028721-x6f26ahr 3876 14 gures gures NNP cord-028721-x6f26ahr 3876 15 and and CC cord-028721-x6f26ahr 3876 16 infi infi NNP cord-028721-x6f26ahr 3876 17 ltrates ltrates NNP cord-028721-x6f26ahr 3876 18 adjacent adjacent JJ cord-028721-x6f26ahr 3876 19 structures structure NNS cord-028721-x6f26ahr 3876 20 . . . cord-028721-x6f26ahr 3877 1 1652 1652 CD cord-028721-x6f26ahr 3877 2 Metastasis metastasis NN cord-028721-x6f26ahr 3877 3 of of IN cord-028721-x6f26ahr 3877 4 prostatic prostatic JJ cord-028721-x6f26ahr 3877 5 adenocarcinoma adenocarcinoma NN cord-028721-x6f26ahr 3877 6 may may MD cord-028721-x6f26ahr 3877 7 be be VB cord-028721-x6f26ahr 3877 8 excluded exclude VBN cord-028721-x6f26ahr 3877 9 because because IN cord-028721-x6f26ahr 3877 10 these these DT cord-028721-x6f26ahr 3877 11 metastases metastasis NNS cord-028721-x6f26ahr 3877 12 alter alter VBP cord-028721-x6f26ahr 3877 13 the the DT cord-028721-x6f26ahr 3877 14 rete rete NN cord-028721-x6f26ahr 3877 15 testis testis NN cord-028721-x6f26ahr 3877 16 architecture architecture NN cord-028721-x6f26ahr 3877 17 and and CC cord-028721-x6f26ahr 3877 18 are be VBP cord-028721-x6f26ahr 3877 19 immunoreactive immunoreactive JJ cord-028721-x6f26ahr 3877 20 for for IN cord-028721-x6f26ahr 3877 21 prostatic prostatic JJ cord-028721-x6f26ahr 3877 22 acid acid NN cord-028721-x6f26ahr 3877 23 phosphatase phosphatase NN cord-028721-x6f26ahr 3877 24 and and CC cord-028721-x6f26ahr 3877 25 PSA PSA NNP cord-028721-x6f26ahr 3877 26 . . . cord-028721-x6f26ahr 3878 1 This this DT cord-028721-x6f26ahr 3878 2 reactive reactive JJ cord-028721-x6f26ahr 3878 3 lesion lesion NN cord-028721-x6f26ahr 3878 4 is be VBZ cord-028721-x6f26ahr 3878 5 characterized characterize VBN cord-028721-x6f26ahr 3878 6 by by IN cord-028721-x6f26ahr 3878 7 the the DT cord-028721-x6f26ahr 3878 8 presence presence NN cord-028721-x6f26ahr 3878 9 of of IN cord-028721-x6f26ahr 3878 10 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 3878 11 accumulation accumulation NN cord-028721-x6f26ahr 3878 12 of of IN cord-028721-x6f26ahr 3878 13 hyaline hyaline JJ cord-028721-x6f26ahr 3878 14 eosinophilic eosinophilic JJ cord-028721-x6f26ahr 3878 15 globules globule NNS cord-028721-x6f26ahr 3878 16 in in IN cord-028721-x6f26ahr 3878 17 the the DT cord-028721-x6f26ahr 3878 18 epithelial epithelial JJ cord-028721-x6f26ahr 3878 19 cells cell NNS cord-028721-x6f26ahr 3878 20 of of IN cord-028721-x6f26ahr 3878 21 the the DT cord-028721-x6f26ahr 3878 22 rete rete NN cord-028721-x6f26ahr 3878 23 testis testis NN cord-028721-x6f26ahr 3878 24 . . . cord-028721-x6f26ahr 3879 1 The the DT cord-028721-x6f26ahr 3879 2 epithelium epithelium NN cord-028721-x6f26ahr 3879 3 may may MD cord-028721-x6f26ahr 3879 4 be be VB cord-028721-x6f26ahr 3879 5 hyperplastic hyperplastic JJ cord-028721-x6f26ahr 3879 6 , , , cord-028721-x6f26ahr 3879 7 but but CC cord-028721-x6f26ahr 3879 8 does do VBZ cord-028721-x6f26ahr 3879 9 not not RB cord-028721-x6f26ahr 3879 10 contain contain VB cord-028721-x6f26ahr 3879 11 mitotic mitotic JJ cord-028721-x6f26ahr 3879 12 fi fi NN cord-028721-x6f26ahr 3879 13 gures gure NNS cord-028721-x6f26ahr 3879 14 or or CC cord-028721-x6f26ahr 3879 15 nuclear nuclear JJ cord-028721-x6f26ahr 3879 16 atypia atypia NN cord-028721-x6f26ahr 3879 17 . . . cord-028721-x6f26ahr 3880 1 The the DT cord-028721-x6f26ahr 3880 2 globules globule NNS cord-028721-x6f26ahr 3880 3 are be VBP cord-028721-x6f26ahr 3880 4 up up RB cord-028721-x6f26ahr 3880 5 to to TO cord-028721-x6f26ahr 3880 6 15 15 CD cord-028721-x6f26ahr 3880 7 µm µm NNS cord-028721-x6f26ahr 3880 8 in in IN cord-028721-x6f26ahr 3880 9 diameter diameter NN cord-028721-x6f26ahr 3881 1 ( ( -LRB- cord-028721-x6f26ahr 3881 2 Fig Fig NNP cord-028721-x6f26ahr 3881 3 . . . cord-028721-x6f26ahr 3881 4 12 12 CD cord-028721-x6f26ahr 3881 5 - - SYM cord-028721-x6f26ahr 3881 6 174 174 CD cord-028721-x6f26ahr 3881 7 ) ) -RRB- cord-028721-x6f26ahr 3881 8 . . . cord-028721-x6f26ahr 3882 1 This this DT cord-028721-x6f26ahr 3882 2 lesion lesion NN cord-028721-x6f26ahr 3882 3 is be VBZ cord-028721-x6f26ahr 3882 4 associated associate VBN cord-028721-x6f26ahr 3882 5 with with IN cord-028721-x6f26ahr 3882 6 tumor tumor NN cord-028721-x6f26ahr 3882 7 and and CC cord-028721-x6f26ahr 3882 8 infl infl NNP cord-028721-x6f26ahr 3882 9 ammatory ammatory NN cord-028721-x6f26ahr 3882 10 processes process NNS cord-028721-x6f26ahr 3882 11 occurring occur VBG cord-028721-x6f26ahr 3882 12 near near IN cord-028721-x6f26ahr 3882 13 the the DT cord-028721-x6f26ahr 3882 14 mediastinum mediastinum JJ cord-028721-x6f26ahr 3882 15 testis testis NN cord-028721-x6f26ahr 3882 16 , , , cord-028721-x6f26ahr 3882 17 and and CC cord-028721-x6f26ahr 3882 18 can can MD cord-028721-x6f26ahr 3882 19 be be VB cord-028721-x6f26ahr 3882 20 observed observe VBN cord-028721-x6f26ahr 3882 21 in in IN cord-028721-x6f26ahr 3882 22 association association NN cord-028721-x6f26ahr 3882 23 with with IN cord-028721-x6f26ahr 3882 24 75 75 CD cord-028721-x6f26ahr 3882 25 % % NN cord-028721-x6f26ahr 3882 26 of of IN cord-028721-x6f26ahr 3882 27 mixed mixed JJ cord-028721-x6f26ahr 3882 28 testicular testicular JJ cord-028721-x6f26ahr 3882 29 germ germ NN cord-028721-x6f26ahr 3882 30 cell cell NN cord-028721-x6f26ahr 3882 31 tumors tumor NNS cord-028721-x6f26ahr 3882 32 , , , cord-028721-x6f26ahr 3882 33 47 47 CD cord-028721-x6f26ahr 3882 34 % % NN cord-028721-x6f26ahr 3882 35 of of IN cord-028721-x6f26ahr 3882 36 seminomas seminomas NN cord-028721-x6f26ahr 3882 37 , , , cord-028721-x6f26ahr 3882 38 and and CC cord-028721-x6f26ahr 3882 39 20 20 CD cord-028721-x6f26ahr 3882 40 % % NN cord-028721-x6f26ahr 3882 41 of of IN cord-028721-x6f26ahr 3882 42 non non JJ cord-028721-x6f26ahr 3882 43 - - JJ cord-028721-x6f26ahr 3882 44 germ germ JJ cord-028721-x6f26ahr 3882 45 cell cell NN cord-028721-x6f26ahr 3882 46 testicular testicular NN cord-028721-x6f26ahr 3882 47 tumors tumor NNS cord-028721-x6f26ahr 3882 48 , , , cord-028721-x6f26ahr 3882 49 such such JJ cord-028721-x6f26ahr 3882 50 as as IN cord-028721-x6f26ahr 3882 51 epididymal epididymal JJ cord-028721-x6f26ahr 3882 52 tumor tumor NN cord-028721-x6f26ahr 3882 53 that that IN cord-028721-x6f26ahr 3882 54 infi infi NNP cord-028721-x6f26ahr 3882 55 ltrates ltrate VBZ cord-028721-x6f26ahr 3882 56 the the DT cord-028721-x6f26ahr 3882 57 testis testis NN cord-028721-x6f26ahr 3882 58 ( ( -LRB- cord-028721-x6f26ahr 3882 59 adenomatoid adenomatoid NNP cord-028721-x6f26ahr 3882 60 tumor tumor NN cord-028721-x6f26ahr 3882 61 ) ) -RRB- cord-028721-x6f26ahr 3882 62 . . . cord-028721-x6f26ahr 3883 1 1653 1653 CD cord-028721-x6f26ahr 3883 2 Yolk Yolk NNP cord-028721-x6f26ahr 3883 3 sac sac NN cord-028721-x6f26ahr 3883 4 tumor tumor NN cord-028721-x6f26ahr 3883 5 infi infi NNP cord-028721-x6f26ahr 3883 6 ltrating ltrate VBG cord-028721-x6f26ahr 3883 7 the the DT cord-028721-x6f26ahr 3883 8 rete rete NNP cord-028721-x6f26ahr 3883 9 testis testis NN cord-028721-x6f26ahr 3883 10 may may MD cord-028721-x6f26ahr 3883 11 closely closely RB cord-028721-x6f26ahr 3883 12 resemble resemble VB cord-028721-x6f26ahr 3883 13 this this DT cord-028721-x6f26ahr 3883 14 type type NN cord-028721-x6f26ahr 3883 15 of of IN cord-028721-x6f26ahr 3883 16 rete rete NN cord-028721-x6f26ahr 3883 17 testis testis NN cord-028721-x6f26ahr 3883 18 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3883 19 . . . cord-028721-x6f26ahr 3884 1 Positive positive JJ cord-028721-x6f26ahr 3884 2 immunoreactions immunoreaction NNS cord-028721-x6f26ahr 3884 3 for for IN cord-028721-x6f26ahr 3884 4 α α NN cord-028721-x6f26ahr 3884 5 - - HYPH cord-028721-x6f26ahr 3884 6 fetoprotein fetoprotein NNP cord-028721-x6f26ahr 3884 7 and and CC cord-028721-x6f26ahr 3884 8 placenta placenta NN cord-028721-x6f26ahr 3884 9 - - HYPH cord-028721-x6f26ahr 3884 10 like like JJ cord-028721-x6f26ahr 3884 11 alkaline alkaline JJ cord-028721-x6f26ahr 3884 12 phosphatase phosphatase NN cord-028721-x6f26ahr 3884 13 , , , cord-028721-x6f26ahr 3884 14 as as RB cord-028721-x6f26ahr 3884 15 well well RB cord-028721-x6f26ahr 3884 16 as as IN cord-028721-x6f26ahr 3884 17 nuclear nuclear JJ cord-028721-x6f26ahr 3884 18 atypia atypia NN cord-028721-x6f26ahr 3884 19 , , , cord-028721-x6f26ahr 3884 20 are be VBP cord-028721-x6f26ahr 3884 21 helpful helpful JJ cord-028721-x6f26ahr 3884 22 to to TO cord-028721-x6f26ahr 3884 23 distinguish distinguish VB cord-028721-x6f26ahr 3884 24 germ germ NN cord-028721-x6f26ahr 3884 25 cell cell NN cord-028721-x6f26ahr 3884 26 neoplasia neoplasia NN cord-028721-x6f26ahr 3884 27 from from IN cord-028721-x6f26ahr 3884 28 this this DT cord-028721-x6f26ahr 3884 29 rete rete FW cord-028721-x6f26ahr 3884 30 testis testis NN cord-028721-x6f26ahr 3884 31 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3884 32 . . . cord-028721-x6f26ahr 3885 1 1654 1654 CD cord-028721-x6f26ahr 3886 1 This this DT cord-028721-x6f26ahr 3886 2 lesion lesion NN cord-028721-x6f26ahr 3886 3 , , , cord-028721-x6f26ahr 3886 4 described describe VBN cord-028721-x6f26ahr 3886 5 as as IN cord-028721-x6f26ahr 3886 6 nodular nodular JJ cord-028721-x6f26ahr 3886 7 proliferation proliferation NN cord-028721-x6f26ahr 3886 8 of of IN cord-028721-x6f26ahr 3886 9 calcifying calcify VBG cord-028721-x6f26ahr 3886 10 connective connective JJ cord-028721-x6f26ahr 3886 11 tissue tissue NN cord-028721-x6f26ahr 3886 12 in in IN cord-028721-x6f26ahr 3886 13 the the DT cord-028721-x6f26ahr 3886 14 rete rete NN cord-028721-x6f26ahr 3886 15 testis testis NN cord-028721-x6f26ahr 3886 16 , , , cord-028721-x6f26ahr 3886 17 is be VBZ cord-028721-x6f26ahr 3886 18 characterized characterize VBN cord-028721-x6f26ahr 3886 19 by by IN cord-028721-x6f26ahr 3886 20 the the DT cord-028721-x6f26ahr 3886 21 presence presence NN cord-028721-x6f26ahr 3886 22 of of IN cord-028721-x6f26ahr 3886 23 multiple multiple JJ cord-028721-x6f26ahr 3886 24 nodules nodule NNS cord-028721-x6f26ahr 3886 25 that that WDT cord-028721-x6f26ahr 3886 26 originate originate VBP cord-028721-x6f26ahr 3886 27 from from IN cord-028721-x6f26ahr 3886 28 the the DT cord-028721-x6f26ahr 3886 29 rete rete NNP cord-028721-x6f26ahr 3886 30 testis testis NN cord-028721-x6f26ahr 3886 31 lining lining NN cord-028721-x6f26ahr 3886 32 and and CC cord-028721-x6f26ahr 3886 33 subjacent subjacent VB cord-028721-x6f26ahr 3886 34 connective connective JJ cord-028721-x6f26ahr 3886 35 tissue tissue NN cord-028721-x6f26ahr 3886 36 , , , cord-028721-x6f26ahr 3886 37 protruding protrude VBG cord-028721-x6f26ahr 3886 38 into into IN cord-028721-x6f26ahr 3886 39 the the DT cord-028721-x6f26ahr 3886 40 channels channel NNS cord-028721-x6f26ahr 3886 41 of of IN cord-028721-x6f26ahr 3886 42 the the DT cord-028721-x6f26ahr 3886 43 rete rete NN cord-028721-x6f26ahr 3886 44 testis testis NN cord-028721-x6f26ahr 3886 45 . . . cord-028721-x6f26ahr 3887 1 These these DT cord-028721-x6f26ahr 3887 2 consist consist VBP cord-028721-x6f26ahr 3887 3 of of IN cord-028721-x6f26ahr 3887 4 cellular cellular JJ cord-028721-x6f26ahr 3887 5 connective connective JJ cord-028721-x6f26ahr 3887 6 tissue tissue NN cord-028721-x6f26ahr 3887 7 covered cover VBN cord-028721-x6f26ahr 3887 8 by by IN cord-028721-x6f26ahr 3887 9 several several JJ cord-028721-x6f26ahr 3887 10 layers layer NNS cord-028721-x6f26ahr 3887 11 of of IN cord-028721-x6f26ahr 3887 12 a a DT cord-028721-x6f26ahr 3887 13 fi fi NNP cord-028721-x6f26ahr 3887 14 brin brin NNP cord-028721-x6f26ahr 3887 15 - - HYPH cord-028721-x6f26ahr 3887 16 like like JJ cord-028721-x6f26ahr 3887 17 material material NN cord-028721-x6f26ahr 3887 18 , , , cord-028721-x6f26ahr 3887 19 which which WDT cord-028721-x6f26ahr 3887 20 in in IN cord-028721-x6f26ahr 3887 21 turn turn NN cord-028721-x6f26ahr 3887 22 is be VBZ cord-028721-x6f26ahr 3887 23 covered cover VBN cord-028721-x6f26ahr 3887 24 by by IN cord-028721-x6f26ahr 3887 25 rete rete NN cord-028721-x6f26ahr 3887 26 testis testis NN cord-028721-x6f26ahr 3887 27 epithelium epithelium NN cord-028721-x6f26ahr 3887 28 . . . cord-028721-x6f26ahr 3888 1 The the DT cord-028721-x6f26ahr 3888 2 nodules nodule NNS cord-028721-x6f26ahr 3888 3 may may MD cord-028721-x6f26ahr 3888 4 be be VB cord-028721-x6f26ahr 3888 5 totally totally RB cord-028721-x6f26ahr 3888 6 or or CC cord-028721-x6f26ahr 3888 7 partially partially RB cord-028721-x6f26ahr 3888 8 calcifi calcifi NNP cord-028721-x6f26ahr 3888 9 ed ed NNP cord-028721-x6f26ahr 3888 10 ( ( -LRB- cord-028721-x6f26ahr 3888 11 Fig Fig NNP cord-028721-x6f26ahr 3888 12 . . . cord-028721-x6f26ahr 3888 13 12 12 CD cord-028721-x6f26ahr 3888 14 - - SYM cord-028721-x6f26ahr 3888 15 175 175 CD cord-028721-x6f26ahr 3888 16 ) ) -RRB- cord-028721-x6f26ahr 3888 17 . . . cord-028721-x6f26ahr 3889 1 1655 1655 CD cord-028721-x6f26ahr 3890 1 The the DT cord-028721-x6f26ahr 3890 2 lesion lesion NN cord-028721-x6f26ahr 3890 3 is be VBZ cord-028721-x6f26ahr 3890 4 an an DT cord-028721-x6f26ahr 3890 5 incidental incidental JJ cord-028721-x6f26ahr 3890 6 fi fi NN cord-028721-x6f26ahr 3890 7 nding nding NN cord-028721-x6f26ahr 3890 8 at at IN cord-028721-x6f26ahr 3890 9 autopsy autopsy NN cord-028721-x6f26ahr 3890 10 in in IN cord-028721-x6f26ahr 3890 11 patients patient NNS cord-028721-x6f26ahr 3890 12 with with IN cord-028721-x6f26ahr 3890 13 impaired impaired JJ cord-028721-x6f26ahr 3890 14 peripheral peripheral JJ cord-028721-x6f26ahr 3890 15 perfusion perfusion NN cord-028721-x6f26ahr 3890 16 . . . cord-028721-x6f26ahr 3891 1 Selective selective JJ cord-028721-x6f26ahr 3891 2 location location NN cord-028721-x6f26ahr 3891 3 of of IN cord-028721-x6f26ahr 3891 4 the the DT cord-028721-x6f26ahr 3891 5 lesion lesion NN cord-028721-x6f26ahr 3891 6 in in IN cord-028721-x6f26ahr 3891 7 the the DT cord-028721-x6f26ahr 3891 8 walls wall NNS cord-028721-x6f26ahr 3891 9 of of IN cord-028721-x6f26ahr 3891 10 the the DT cord-028721-x6f26ahr 3891 11 cavities cavity NNS cord-028721-x6f26ahr 3891 12 and and CC cord-028721-x6f26ahr 3891 13 chordae chordae NNP cord-028721-x6f26ahr 3891 14 rete rete NNP cord-028721-x6f26ahr 3891 15 testis testis NN cord-028721-x6f26ahr 3891 16 is be VBZ cord-028721-x6f26ahr 3891 17 probably probably RB cord-028721-x6f26ahr 3891 18 related relate VBN cord-028721-x6f26ahr 3891 19 to to IN cord-028721-x6f26ahr 3891 20 poor poor JJ cord-028721-x6f26ahr 3891 21 vascularization vascularization NN cord-028721-x6f26ahr 3891 22 of of IN cord-028721-x6f26ahr 3891 23 these these DT cord-028721-x6f26ahr 3891 24 structures structure NNS cord-028721-x6f26ahr 3891 25 . . . cord-028721-x6f26ahr 3892 1 The the DT cord-028721-x6f26ahr 3892 2 etiopathogenetic etiopathogenetic JJ cord-028721-x6f26ahr 3892 3 mechanism mechanism NN cord-028721-x6f26ahr 3892 4 may may MD cord-028721-x6f26ahr 3892 5 be be VB cord-028721-x6f26ahr 3892 6 anoxia anoxia NN cord-028721-x6f26ahr 3892 7 , , , cord-028721-x6f26ahr 3892 8 necrosis necrosis NN cord-028721-x6f26ahr 3892 9 , , , cord-028721-x6f26ahr 3892 10 fi fi NNP cord-028721-x6f26ahr 3892 11 brin brin NNP cord-028721-x6f26ahr 3892 12 deposition deposition NN cord-028721-x6f26ahr 3892 13 , , , cord-028721-x6f26ahr 3892 14 proliferation proliferation NN cord-028721-x6f26ahr 3892 15 of of IN cord-028721-x6f26ahr 3892 16 connective connective JJ cord-028721-x6f26ahr 3892 17 tissue tissue NN cord-028721-x6f26ahr 3892 18 , , , cord-028721-x6f26ahr 3892 19 or or CC cord-028721-x6f26ahr 3892 20 dystrophic dystrophic NNP cord-028721-x6f26ahr 3892 21 calcifi calcifi NNP cord-028721-x6f26ahr 3892 22 cation cation NNP cord-028721-x6f26ahr 3892 23 . . . cord-028721-x6f26ahr 3893 1 The the DT cord-028721-x6f26ahr 3893 2 intracavitary intracavitary JJ cord-028721-x6f26ahr 3893 3 growth growth NN cord-028721-x6f26ahr 3893 4 of of IN cord-028721-x6f26ahr 3893 5 the the DT cord-028721-x6f26ahr 3893 6 lesion lesion NN cord-028721-x6f26ahr 3893 7 might may MD cord-028721-x6f26ahr 3893 8 be be VB cord-028721-x6f26ahr 3893 9 due due JJ cord-028721-x6f26ahr 3893 10 to to IN cord-028721-x6f26ahr 3893 11 the the DT cord-028721-x6f26ahr 3893 12 lower low JJR cord-028721-x6f26ahr 3893 13 intracavitary intracavitary JJ cord-028721-x6f26ahr 3893 14 pressure pressure NN cord-028721-x6f26ahr 3893 15 and and CC cord-028721-x6f26ahr 3893 16 also also RB cord-028721-x6f26ahr 3893 17 to to IN cord-028721-x6f26ahr 3893 18 the the DT cord-028721-x6f26ahr 3893 19 stiff stiff JJ cord-028721-x6f26ahr 3893 20 structure structure NN cord-028721-x6f26ahr 3893 21 of of IN cord-028721-x6f26ahr 3893 22 the the DT cord-028721-x6f26ahr 3893 23 mediastinum mediastinum NNP cord-028721-x6f26ahr 3893 24 testis testis NN cord-028721-x6f26ahr 3893 25 . . . cord-028721-x6f26ahr 3893 26 _SP cord-028721-x6f26ahr 3894 1 The the DT cord-028721-x6f26ahr 3894 2 molecular molecular JJ cord-028721-x6f26ahr 3894 3 basis basis NN cord-028721-x6f26ahr 3894 4 of of IN cord-028721-x6f26ahr 3894 5 male male JJ cord-028721-x6f26ahr 3894 6 sexual sexual JJ cord-028721-x6f26ahr 3894 7 differentiation differentiation NN cord-028721-x6f26ahr 3894 8 Homozygous Homozygous NNP cord-028721-x6f26ahr 3894 9 deletions deletion NNS cord-028721-x6f26ahr 3894 10 in in IN cord-028721-x6f26ahr 3894 11 Wilms'tumours wilms'tumours CD cord-028721-x6f26ahr 3894 12 of of IN cord-028721-x6f26ahr 3894 13 a a DT cord-028721-x6f26ahr 3894 14 zinc zinc NN cord-028721-x6f26ahr 3894 15 - - HYPH cord-028721-x6f26ahr 3894 16 fi fi NN cord-028721-x6f26ahr 3894 17 nger nger NNP cord-028721-x6f26ahr 3894 18 gene gene NNP cord-028721-x6f26ahr 3894 19 identifi identifi NNP cord-028721-x6f26ahr 3894 20 ed ed NNP cord-028721-x6f26ahr 3894 21 by by IN cord-028721-x6f26ahr 3894 22 chromosome chromosome NN cord-028721-x6f26ahr 3894 23 jumping jump VBG cord-028721-x6f26ahr 3894 24 Isolation isolation NN cord-028721-x6f26ahr 3894 25 and and CC cord-028721-x6f26ahr 3894 26 characterization characterization NN cord-028721-x6f26ahr 3894 27 of of IN cord-028721-x6f26ahr 3894 28 a a DT cord-028721-x6f26ahr 3894 29 zinc zinc NN cord-028721-x6f26ahr 3894 30 fi fi NN cord-028721-x6f26ahr 3894 31 nger nger NN cord-028721-x6f26ahr 3894 32 polypeptide polypeptide NN cord-028721-x6f26ahr 3894 33 gene gene NN cord-028721-x6f26ahr 3894 34 at at IN cord-028721-x6f26ahr 3894 35 the the DT cord-028721-x6f26ahr 3894 36 human human JJ cord-028721-x6f26ahr 3894 37 chromosome chromosome NN cord-028721-x6f26ahr 3894 38 11 11 CD cord-028721-x6f26ahr 3894 39 Wilms Wilms NNP cord-028721-x6f26ahr 3894 40 ' ' POS cord-028721-x6f26ahr 3894 41 tumor tumor NN cord-028721-x6f26ahr 3894 42 locus locus NN cord-028721-x6f26ahr 3894 43 WT-1 WT-1 NNP cord-028721-x6f26ahr 3894 44 is be VBZ cord-028721-x6f26ahr 3894 45 required require VBN cord-028721-x6f26ahr 3894 46 for for IN cord-028721-x6f26ahr 3894 47 early early JJ cord-028721-x6f26ahr 3894 48 kidney kidney NN cord-028721-x6f26ahr 3894 49 development development NN cord-028721-x6f26ahr 3894 50 Germline Germline NNP cord-028721-x6f26ahr 3894 51 mutations mutation NNS cord-028721-x6f26ahr 3894 52 in in IN cord-028721-x6f26ahr 3894 53 the the DT cord-028721-x6f26ahr 3894 54 Wilms Wilms NNP cord-028721-x6f26ahr 3894 55 ' ' POS cord-028721-x6f26ahr 3894 56 tumor tumor NN cord-028721-x6f26ahr 3894 57 suppressor suppressor NN cord-028721-x6f26ahr 3894 58 gene gene NN cord-028721-x6f26ahr 3894 59 are be VBP cord-028721-x6f26ahr 3894 60 associated associate VBN cord-028721-x6f26ahr 3894 61 with with IN cord-028721-x6f26ahr 3894 62 abnormal abnormal JJ cord-028721-x6f26ahr 3894 63 urogenital urogenital JJ cord-028721-x6f26ahr 3894 64 development development NN cord-028721-x6f26ahr 3894 65 in in IN cord-028721-x6f26ahr 3894 66 Denys Denys NNP cord-028721-x6f26ahr 3894 67 - - HYPH cord-028721-x6f26ahr 3894 68 Drash Drash NNP cord-028721-x6f26ahr 3894 69 syndrome syndrome NN cord-028721-x6f26ahr 3894 70 Donor donor NN cord-028721-x6f26ahr 3894 71 splice splice NN cord-028721-x6f26ahr 3894 72 - - HYPH cord-028721-x6f26ahr 3894 73 site site NN cord-028721-x6f26ahr 3894 74 mutations mutation NNS cord-028721-x6f26ahr 3894 75 in in IN cord-028721-x6f26ahr 3894 76 WT1 wt1 WP cord-028721-x6f26ahr 3894 77 are be VBP cord-028721-x6f26ahr 3894 78 responsible responsible JJ cord-028721-x6f26ahr 3894 79 for for IN cord-028721-x6f26ahr 3894 80 Frasier Frasier NNP cord-028721-x6f26ahr 3894 81 syndrome syndrome NN cord-028721-x6f26ahr 3894 82 Expression Expression NNP cord-028721-x6f26ahr 3894 83 of of IN cord-028721-x6f26ahr 3894 84 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 3894 85 factor factor NN cord-028721-x6f26ahr 3894 86 1 1 CD cord-028721-x6f26ahr 3894 87 and and CC cord-028721-x6f26ahr 3894 88 Wilms Wilms NNP cord-028721-x6f26ahr 3894 89 ' ' POS cord-028721-x6f26ahr 3894 90 tumour tumour NN cord-028721-x6f26ahr 3894 91 1 1 CD cord-028721-x6f26ahr 3894 92 during during IN cord-028721-x6f26ahr 3894 93 early early JJ cord-028721-x6f26ahr 3894 94 human human JJ cord-028721-x6f26ahr 3894 95 gonadal gonadal JJ cord-028721-x6f26ahr 3894 96 development development NN cord-028721-x6f26ahr 3894 97 and and CC cord-028721-x6f26ahr 3894 98 sex sex NN cord-028721-x6f26ahr 3894 99 determination determination NN cord-028721-x6f26ahr 3894 100 A a DT cord-028721-x6f26ahr 3894 101 mutation mutation NN cord-028721-x6f26ahr 3894 102 in in IN cord-028721-x6f26ahr 3894 103 the the DT cord-028721-x6f26ahr 3894 104 gene gene NN cord-028721-x6f26ahr 3894 105 encoding encoding NN cord-028721-x6f26ahr 3894 106 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 3894 107 factor-1 factor-1 NNP cord-028721-x6f26ahr 3894 108 causes cause VBZ cord-028721-x6f26ahr 3894 109 XY XY NNP cord-028721-x6f26ahr 3894 110 sex sex NN cord-028721-x6f26ahr 3894 111 reversal reversal NN cord-028721-x6f26ahr 3894 112 and and CC cord-028721-x6f26ahr 3894 113 adrenal adrenal JJ cord-028721-x6f26ahr 3894 114 failure failure NN cord-028721-x6f26ahr 3894 115 in in IN cord-028721-x6f26ahr 3894 116 humans human NNS cord-028721-x6f26ahr 3894 117 Apparently apparently RB cord-028721-x6f26ahr 3894 118 normal normal JJ cord-028721-x6f26ahr 3894 119 ovarian ovarian JJ cord-028721-x6f26ahr 3894 120 differentiation differentiation NN cord-028721-x6f26ahr 3894 121 in in IN cord-028721-x6f26ahr 3894 122 a a DT cord-028721-x6f26ahr 3894 123 prepubertal prepubertal JJ cord-028721-x6f26ahr 3894 124 girl girl NN cord-028721-x6f26ahr 3894 125 with with IN cord-028721-x6f26ahr 3894 126 transcriptionally transcriptionally RB cord-028721-x6f26ahr 3894 127 inactive inactive JJ cord-028721-x6f26ahr 3894 128 steroidogenic steroidogenic NN cord-028721-x6f26ahr 3894 129 factor factor NN cord-028721-x6f26ahr 3894 130 1 1 CD cord-028721-x6f26ahr 3895 1 ( ( -LRB- cord-028721-x6f26ahr 3895 2 NR5A1 NR5A1 NNP cord-028721-x6f26ahr 3895 3 / / SYM cord-028721-x6f26ahr 3895 4 SF-1 SF-1 NNP cord-028721-x6f26ahr 3895 5 ) ) -RRB- cord-028721-x6f26ahr 3895 6 and and CC cord-028721-x6f26ahr 3895 7 adrenal adrenal JJ cord-028721-x6f26ahr 3895 8 cortical cortical JJ cord-028721-x6f26ahr 3895 9 insuffi insuffi NNP cord-028721-x6f26ahr 3895 10 ciency ciency NNP cord-028721-x6f26ahr 3896 1 Genetic genetic JJ cord-028721-x6f26ahr 3896 2 control control NN cord-028721-x6f26ahr 3896 3 of of IN cord-028721-x6f26ahr 3896 4 gonadal gonadal JJ cord-028721-x6f26ahr 3896 5 differentiation differentiation NN cord-028721-x6f26ahr 3896 6 , , , cord-028721-x6f26ahr 3897 1 Baillière Baillière NNP cord-028721-x6f26ahr 3897 2 's 's POS cord-028721-x6f26ahr 3897 3 Single single JJ cord-028721-x6f26ahr 3897 4 - - HYPH cord-028721-x6f26ahr 3897 5 copy copy NN cord-028721-x6f26ahr 3897 6 DNA dna NN cord-028721-x6f26ahr 3897 7 sequences sequence NNS cord-028721-x6f26ahr 3897 8 specifi specifi NNP cord-028721-x6f26ahr 3897 9 c c NN cord-028721-x6f26ahr 3897 10 for for IN cord-028721-x6f26ahr 3897 11 the the DT cord-028721-x6f26ahr 3897 12 human human JJ cord-028721-x6f26ahr 3897 13 Y Y NNP cord-028721-x6f26ahr 3897 14 chromosome chromosome NN cord-028721-x6f26ahr 3897 15 Sex sex NN cord-028721-x6f26ahr 3897 16 determination determination NN cord-028721-x6f26ahr 3897 17 and and CC cord-028721-x6f26ahr 3897 18 the the DT cord-028721-x6f26ahr 3897 19 Y Y NNP cord-028721-x6f26ahr 3897 20 chromosome chromosome NN cord-028721-x6f26ahr 3897 21 Gonadal Gonadal NNP cord-028721-x6f26ahr 3898 1 differentiation differentiation NN cord-028721-x6f26ahr 3898 2 : : : cord-028721-x6f26ahr 3898 3 a a DT cord-028721-x6f26ahr 3898 4 review review NN cord-028721-x6f26ahr 3898 5 of of IN cord-028721-x6f26ahr 3898 6 the the DT cord-028721-x6f26ahr 3898 7 physiological physiological JJ cord-028721-x6f26ahr 3898 8 process process NN cord-028721-x6f26ahr 3898 9 and and CC cord-028721-x6f26ahr 3898 10 infl infl NN cord-028721-x6f26ahr 3898 11 uencing uencing NN cord-028721-x6f26ahr 3898 12 factors factor NNS cord-028721-x6f26ahr 3898 13 based base VBN cord-028721-x6f26ahr 3898 14 on on IN cord-028721-x6f26ahr 3898 15 recent recent JJ cord-028721-x6f26ahr 3898 16 experimental experimental JJ cord-028721-x6f26ahr 3898 17 evidence evidence NN cord-028721-x6f26ahr 3899 1 The the DT cord-028721-x6f26ahr 3899 2 human human JJ cord-028721-x6f26ahr 3899 3 SRY sry NN cord-028721-x6f26ahr 3899 4 protein protein NN cord-028721-x6f26ahr 3899 5 is be VBZ cord-028721-x6f26ahr 3899 6 present present JJ cord-028721-x6f26ahr 3899 7 in in IN cord-028721-x6f26ahr 3899 8 fetal fetal JJ cord-028721-x6f26ahr 3899 9 and and CC cord-028721-x6f26ahr 3899 10 adult adult NN cord-028721-x6f26ahr 3899 11 Sertoli sertoli JJ cord-028721-x6f26ahr 3899 12 cells cell NNS cord-028721-x6f26ahr 3899 13 and and CC cord-028721-x6f26ahr 3899 14 germ germ NN cord-028721-x6f26ahr 3899 15 cells cell NNS cord-028721-x6f26ahr 3900 1 Molecular molecular JJ cord-028721-x6f26ahr 3900 2 basis basis NN cord-028721-x6f26ahr 3900 3 of of IN cord-028721-x6f26ahr 3900 4 mammalian mammalian JJ cord-028721-x6f26ahr 3900 5 sexual sexual JJ cord-028721-x6f26ahr 3900 6 determination determination NN cord-028721-x6f26ahr 3900 7 : : : cord-028721-x6f26ahr 3900 8 activation activation NN cord-028721-x6f26ahr 3900 9 of of IN cord-028721-x6f26ahr 3900 10 Müllerian müllerian JJ cord-028721-x6f26ahr 3900 11 inhibiting inhibit VBG cord-028721-x6f26ahr 3900 12 substance substance NN cord-028721-x6f26ahr 3900 13 gene gene NN cord-028721-x6f26ahr 3900 14 expression expression NN cord-028721-x6f26ahr 3900 15 by by IN cord-028721-x6f26ahr 3900 16 SRY SRY NNP cord-028721-x6f26ahr 3900 17 Autosomal autosomal JJ cord-028721-x6f26ahr 3900 18 XX xx NN cord-028721-x6f26ahr 3900 19 sex sex NN cord-028721-x6f26ahr 3900 20 reversal reversal NN cord-028721-x6f26ahr 3900 21 caused cause VBN cord-028721-x6f26ahr 3900 22 by by IN cord-028721-x6f26ahr 3900 23 duplication duplication NN cord-028721-x6f26ahr 3900 24 of of IN cord-028721-x6f26ahr 3900 25 SOX-9 SOX-9 NNP cord-028721-x6f26ahr 3900 26 Campomelic Campomelic NNP cord-028721-x6f26ahr 3900 27 dysplasia dysplasia NN cord-028721-x6f26ahr 3900 28 and and CC cord-028721-x6f26ahr 3900 29 autosomal autosomal JJ cord-028721-x6f26ahr 3900 30 sex sex NN cord-028721-x6f26ahr 3900 31 reversal reversal NN cord-028721-x6f26ahr 3900 32 caused cause VBN cord-028721-x6f26ahr 3900 33 by by IN cord-028721-x6f26ahr 3900 34 mutations mutation NNS cord-028721-x6f26ahr 3900 35 in in IN cord-028721-x6f26ahr 3900 36 an an DT cord-028721-x6f26ahr 3900 37 SRY sry NN cord-028721-x6f26ahr 3900 38 - - HYPH cord-028721-x6f26ahr 3900 39 related relate VBN cord-028721-x6f26ahr 3900 40 gene gene NN cord-028721-x6f26ahr 3900 41 Functional functional JJ cord-028721-x6f26ahr 3900 42 analysis analysis NN cord-028721-x6f26ahr 3900 43 of of IN cord-028721-x6f26ahr 3900 44 Sox8 Sox8 NNP cord-028721-x6f26ahr 3900 45 and and CC cord-028721-x6f26ahr 3900 46 Sox9 Sox9 NNP cord-028721-x6f26ahr 3900 47 during during IN cord-028721-x6f26ahr 3900 48 sex sex NN cord-028721-x6f26ahr 3900 49 determination determination NN cord-028721-x6f26ahr 3900 50 in in IN cord-028721-x6f26ahr 3900 51 the the DT cord-028721-x6f26ahr 3900 52 mouse mouse NN cord-028721-x6f26ahr 3900 53 Autosomal autosomal JJ cord-028721-x6f26ahr 3900 54 sex sex NN cord-028721-x6f26ahr 3900 55 reversal reversal NN cord-028721-x6f26ahr 3900 56 and and CC cord-028721-x6f26ahr 3900 57 campomelic campomelic JJ cord-028721-x6f26ahr 3900 58 dysplasia dysplasia NN cord-028721-x6f26ahr 3900 59 are be VBP cord-028721-x6f26ahr 3900 60 caused cause VBN cord-028721-x6f26ahr 3900 61 by by IN cord-028721-x6f26ahr 3900 62 mutations mutation NNS cord-028721-x6f26ahr 3900 63 in in IN cord-028721-x6f26ahr 3900 64 and and CC cord-028721-x6f26ahr 3900 65 around around IN cord-028721-x6f26ahr 3900 66 the the DT cord-028721-x6f26ahr 3900 67 SRYrelated sryrelate VBN cord-028721-x6f26ahr 3900 68 gene gene NN cord-028721-x6f26ahr 3900 69 SOX9 SOX9 NNP cord-028721-x6f26ahr 3900 70 Similar similar JJ cord-028721-x6f26ahr 3900 71 gene gene NN cord-028721-x6f26ahr 3900 72 structure structure NN cord-028721-x6f26ahr 3900 73 of of IN cord-028721-x6f26ahr 3900 74 two two CD cord-028721-x6f26ahr 3900 75 Sox9a Sox9a NNP cord-028721-x6f26ahr 3900 76 genes gene NNS cord-028721-x6f26ahr 3900 77 and and CC cord-028721-x6f26ahr 3900 78 their -PRON- PRP$ cord-028721-x6f26ahr 3900 79 expression expression NN cord-028721-x6f26ahr 3900 80 patterns pattern NNS cord-028721-x6f26ahr 3900 81 during during IN cord-028721-x6f26ahr 3900 82 gonadal gonadal JJ cord-028721-x6f26ahr 3900 83 differentiation differentiation NN cord-028721-x6f26ahr 3900 84 in in IN cord-028721-x6f26ahr 3900 85 a a DT cord-028721-x6f26ahr 3900 86 teleost teleost NN cord-028721-x6f26ahr 3900 87 fi fi NN cord-028721-x6f26ahr 3900 88 sh sh NN cord-028721-x6f26ahr 3900 89 , , , cord-028721-x6f26ahr 3900 90 rice rice NN cord-028721-x6f26ahr 3900 91 fi fi NN cord-028721-x6f26ahr 3900 92 eld eld NN cord-028721-x6f26ahr 3900 93 eel eel NN cord-028721-x6f26ahr 3901 1 ( ( -LRB- cord-028721-x6f26ahr 3901 2 Monopterus Monopterus NNP cord-028721-x6f26ahr 3901 3 albus albus NN cord-028721-x6f26ahr 3901 4 ) ) -RRB- cord-028721-x6f26ahr 3902 1 Sex sex NN cord-028721-x6f26ahr 3902 2 determination determination NN cord-028721-x6f26ahr 3902 3 : : : cord-028721-x6f26ahr 3902 4 a a DT cord-028721-x6f26ahr 3902 5 tale tale NN cord-028721-x6f26ahr 3902 6 of of IN cord-028721-x6f26ahr 3902 7 two two CD cord-028721-x6f26ahr 3902 8 Sox Sox NNP cord-028721-x6f26ahr 3902 9 genes gene NNS cord-028721-x6f26ahr 3902 10 The the DT cord-028721-x6f26ahr 3902 11 molecular molecular JJ cord-028721-x6f26ahr 3902 12 genetics genetic NNS cord-028721-x6f26ahr 3902 13 of of IN cord-028721-x6f26ahr 3902 14 human human JJ cord-028721-x6f26ahr 3902 15 sex sex NN cord-028721-x6f26ahr 3902 16 determination determination NN cord-028721-x6f26ahr 3902 17 X x NN cord-028721-x6f26ahr 3902 18 - - HYPH cord-028721-x6f26ahr 3902 19 p p NN cord-028721-x6f26ahr 3902 20 duplications duplication NNS cord-028721-x6f26ahr 3902 21 with with IN cord-028721-x6f26ahr 3902 22 and and CC cord-028721-x6f26ahr 3902 23 without without IN cord-028721-x6f26ahr 3902 24 sex sex NN cord-028721-x6f26ahr 3902 25 reversal reversal NN cord-028721-x6f26ahr 3903 1 The the DT cord-028721-x6f26ahr 3903 2 role role NN cord-028721-x6f26ahr 3903 3 of of IN cord-028721-x6f26ahr 3903 4 folliclestimulating folliclestimulate VBG cord-028721-x6f26ahr 3903 5 hormone hormone NN cord-028721-x6f26ahr 3903 6 in in IN cord-028721-x6f26ahr 3903 7 controlling control VBG cord-028721-x6f26ahr 3903 8 Sertoli sertoli JJ cord-028721-x6f26ahr 3903 9 cell cell NN cord-028721-x6f26ahr 3903 10 proliferation proliferation NN cord-028721-x6f26ahr 3903 11 in in IN cord-028721-x6f26ahr 3903 12 testes testis NNS cord-028721-x6f26ahr 3903 13 of of IN cord-028721-x6f26ahr 3903 14 fetal fetal JJ cord-028721-x6f26ahr 3903 15 rats rat NNS cord-028721-x6f26ahr 3903 16 Age age NN cord-028721-x6f26ahr 3903 17 - - HYPH cord-028721-x6f26ahr 3903 18 retated retate VBN cord-028721-x6f26ahr 3903 19 variation variation NN cord-028721-x6f26ahr 3903 20 of of IN cord-028721-x6f26ahr 3903 21 folliclestimulating folliclestimulate VBG cord-028721-x6f26ahr 3903 22 hormone hormone NN cord-028721-x6f26ahr 3903 23 stimulated stimulate VBD cord-028721-x6f26ahr 3903 24 cAMP camp NN cord-028721-x6f26ahr 3903 25 production production NN cord-028721-x6f26ahr 3903 26 , , , cord-028721-x6f26ahr 3903 27 protein protein NN cord-028721-x6f26ahr 3903 28 kinase kinase NN cord-028721-x6f26ahr 3903 29 C C NNP cord-028721-x6f26ahr 3903 30 activity activity NN cord-028721-x6f26ahr 3903 31 and and CC cord-028721-x6f26ahr 3903 32 their -PRON- PRP$ cord-028721-x6f26ahr 3903 33 interactions interaction NNS cord-028721-x6f26ahr 3903 34 on on IN cord-028721-x6f26ahr 3903 35 the the DT cord-028721-x6f26ahr 3903 36 rat rat NN cord-028721-x6f26ahr 3903 37 testis testis NN cord-028721-x6f26ahr 3904 1 The the DT cord-028721-x6f26ahr 3904 2 embryology embryology NN cord-028721-x6f26ahr 3904 3 of of IN cord-028721-x6f26ahr 3904 4 testicular testicular JJ cord-028721-x6f26ahr 3904 5 descent descent NN cord-028721-x6f26ahr 3905 1 The the DT cord-028721-x6f26ahr 3905 2 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3905 3 during during IN cord-028721-x6f26ahr 3905 4 testicular testicular JJ cord-028721-x6f26ahr 3905 5 descent descent NN cord-028721-x6f26ahr 3905 6 in in IN cord-028721-x6f26ahr 3905 7 the the DT cord-028721-x6f26ahr 3905 8 pig pig NN cord-028721-x6f26ahr 3905 9 fetus fetus NN cord-028721-x6f26ahr 3905 10 The the DT cord-028721-x6f26ahr 3905 11 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3905 12 during during IN cord-028721-x6f26ahr 3905 13 testicular testicular JJ cord-028721-x6f26ahr 3905 14 descent descent NN cord-028721-x6f26ahr 3905 15 in in IN cord-028721-x6f26ahr 3905 16 the the DT cord-028721-x6f26ahr 3905 17 human human JJ cord-028721-x6f26ahr 3905 18 fetus fetus NN cord-028721-x6f26ahr 3905 19 Hyperplasia hyperplasia NN cord-028721-x6f26ahr 3905 20 and and CC cord-028721-x6f26ahr 3905 21 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3905 22 of of IN cord-028721-x6f26ahr 3905 23 the the DT cord-028721-x6f26ahr 3905 24 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3905 25 during during IN cord-028721-x6f26ahr 3905 26 testicular testicular JJ cord-028721-x6f26ahr 3905 27 descent descent NN cord-028721-x6f26ahr 3905 28 in in IN cord-028721-x6f26ahr 3905 29 the the DT cord-028721-x6f26ahr 3905 30 fetus fetus NN cord-028721-x6f26ahr 3905 31 Incidence incidence NN cord-028721-x6f26ahr 3905 32 of of IN cord-028721-x6f26ahr 3905 33 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3906 1 The the DT cord-028721-x6f26ahr 3906 2 role role NN cord-028721-x6f26ahr 3906 3 of of IN cord-028721-x6f26ahr 3906 4 a a DT cord-028721-x6f26ahr 3906 5 non non JJ cord-028721-x6f26ahr 3906 6 - - JJ cord-028721-x6f26ahr 3906 7 androgenic androgenic JJ cord-028721-x6f26ahr 3906 8 testicular testicular NN cord-028721-x6f26ahr 3906 9 factor factor NN cord-028721-x6f26ahr 3906 10 in in IN cord-028721-x6f26ahr 3906 11 the the DT cord-028721-x6f26ahr 3906 12 process process NN cord-028721-x6f26ahr 3906 13 of of IN cord-028721-x6f26ahr 3906 14 testicular testicular JJ cord-028721-x6f26ahr 3906 15 descent descent NN cord-028721-x6f26ahr 3906 16 in in IN cord-028721-x6f26ahr 3906 17 the the DT cord-028721-x6f26ahr 3906 18 dog dog NN cord-028721-x6f26ahr 3906 19 Mechanism Mechanism NNP cord-028721-x6f26ahr 3906 20 of of IN cord-028721-x6f26ahr 3906 21 testicular testicular JJ cord-028721-x6f26ahr 3906 22 descent descent NN cord-028721-x6f26ahr 3907 1 The the DT cord-028721-x6f26ahr 3907 2 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3907 3 testis testis NN cord-028721-x6f26ahr 3907 4 Hunteri Hunteri NNP cord-028721-x6f26ahr 3907 5 , , , cord-028721-x6f26ahr 3907 6 testicular testicular JJ cord-028721-x6f26ahr 3907 7 descent descent NN cord-028721-x6f26ahr 3907 8 and and CC cord-028721-x6f26ahr 3907 9 maldescent maldescent JJ cord-028721-x6f26ahr 3907 10 Role role NN cord-028721-x6f26ahr 3907 11 of of IN cord-028721-x6f26ahr 3907 12 the the DT cord-028721-x6f26ahr 3907 13 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3907 14 and and CC cord-028721-x6f26ahr 3907 15 intraabdominal intraabdominal JJ cord-028721-x6f26ahr 3907 16 pressure pressure NN cord-028721-x6f26ahr 3907 17 in in IN cord-028721-x6f26ahr 3907 18 the the DT cord-028721-x6f26ahr 3907 19 process process NN cord-028721-x6f26ahr 3907 20 of of IN cord-028721-x6f26ahr 3907 21 testicular testicular JJ cord-028721-x6f26ahr 3907 22 descent descent NN cord-028721-x6f26ahr 3907 23 Testicular Testicular NNP cord-028721-x6f26ahr 3907 24 descent descent NN cord-028721-x6f26ahr 3907 25 and and CC cord-028721-x6f26ahr 3907 26 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3907 27 : : : cord-028721-x6f26ahr 3907 28 the the DT cord-028721-x6f26ahr 3907 29 state state NN cord-028721-x6f26ahr 3907 30 of of IN cord-028721-x6f26ahr 3907 31 the the DT cord-028721-x6f26ahr 3907 32 art art NN cord-028721-x6f26ahr 3907 33 in in IN cord-028721-x6f26ahr 3907 34 2004 2004 CD cord-028721-x6f26ahr 3908 1 The the DT cord-028721-x6f26ahr 3908 2 insulin-3 insulin-3 NNP cord-028721-x6f26ahr 3908 3 Gene gene NN cord-028721-x6f26ahr 3908 4 : : : cord-028721-x6f26ahr 3909 1 Lack lack NN cord-028721-x6f26ahr 3909 2 of of IN cord-028721-x6f26ahr 3909 3 a a DT cord-028721-x6f26ahr 3909 4 genetic genetic JJ cord-028721-x6f26ahr 3909 5 basis basis NN cord-028721-x6f26ahr 3909 6 for for IN cord-028721-x6f26ahr 3909 7 human human JJ cord-028721-x6f26ahr 3909 8 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3910 1 Transabdominal Transabdominal NNP cord-028721-x6f26ahr 3910 2 testicular testicular JJ cord-028721-x6f26ahr 3910 3 descent descent NN cord-028721-x6f26ahr 3910 4 is be VBZ cord-028721-x6f26ahr 3910 5 disrupted disrupt VBN cord-028721-x6f26ahr 3910 6 in in IN cord-028721-x6f26ahr 3910 7 mice mouse NNS cord-028721-x6f26ahr 3910 8 with with IN cord-028721-x6f26ahr 3910 9 deletion deletion NN cord-028721-x6f26ahr 3910 10 of of IN cord-028721-x6f26ahr 3910 11 insulinlike insulinlike JJ cord-028721-x6f26ahr 3910 12 factor factor NN cord-028721-x6f26ahr 3910 13 3 3 CD cord-028721-x6f26ahr 3910 14 receptor receptor NN cord-028721-x6f26ahr 3910 15 A a DT cord-028721-x6f26ahr 3910 16 novel novel JJ cord-028721-x6f26ahr 3910 17 circulating circulate VBG cord-028721-x6f26ahr 3910 18 hormone hormone NN cord-028721-x6f26ahr 3910 19 of of IN cord-028721-x6f26ahr 3910 20 testis testis NN cord-028721-x6f26ahr 3910 21 origin origin NN cord-028721-x6f26ahr 3910 22 in in IN cord-028721-x6f26ahr 3910 23 humans human NNS cord-028721-x6f26ahr 3910 24 Testicular Testicular NNP cord-028721-x6f26ahr 3910 25 descent descent NN cord-028721-x6f26ahr 3910 26 II II NNP cord-028721-x6f26ahr 3910 27 . . . cord-028721-x6f26ahr 3911 1 Ontogeny ontogeny NN cord-028721-x6f26ahr 3911 2 and and CC cord-028721-x6f26ahr 3911 3 response response NN cord-028721-x6f26ahr 3911 4 to to IN cord-028721-x6f26ahr 3911 5 denervation denervation NN cord-028721-x6f26ahr 3911 6 of of IN cord-028721-x6f26ahr 3911 7 calcitonin calcitonin NN cord-028721-x6f26ahr 3911 8 gene gene NN cord-028721-x6f26ahr 3911 9 - - HYPH cord-028721-x6f26ahr 3911 10 related relate VBN cord-028721-x6f26ahr 3911 11 peptide peptide JJ cord-028721-x6f26ahr 3911 12 receptors receptor NNS cord-028721-x6f26ahr 3911 13 in in IN cord-028721-x6f26ahr 3911 14 neonatal neonatal JJ cord-028721-x6f26ahr 3911 15 rat rat NN cord-028721-x6f26ahr 3911 16 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3911 17 Prenatal prenatal JJ cord-028721-x6f26ahr 3911 18 androgen androgen NN cord-028721-x6f26ahr 3911 19 blockade blockade NN cord-028721-x6f26ahr 3911 20 with with IN cord-028721-x6f26ahr 3911 21 fl fl NNP cord-028721-x6f26ahr 3911 22 utamide utamide NN cord-028721-x6f26ahr 3911 23 inhibits inhibit VBZ cord-028721-x6f26ahr 3911 24 masculinization masculinization NN cord-028721-x6f26ahr 3911 25 of of IN cord-028721-x6f26ahr 3911 26 the the DT cord-028721-x6f26ahr 3911 27 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 3911 28 nerve nerve NN cord-028721-x6f26ahr 3911 29 and and CC cord-028721-x6f26ahr 3911 30 testicular testicular JJ cord-028721-x6f26ahr 3911 31 descent descent NN cord-028721-x6f26ahr 3911 32 Cremaster Cremaster NNP cord-028721-x6f26ahr 3911 33 muscles muscle NNS cord-028721-x6f26ahr 3911 34 obtained obtain VBN cord-028721-x6f26ahr 3911 35 from from IN cord-028721-x6f26ahr 3911 36 boys boy NNS cord-028721-x6f26ahr 3911 37 with with IN cord-028721-x6f26ahr 3911 38 an an DT cord-028721-x6f26ahr 3911 39 undescended undescended JJ cord-028721-x6f26ahr 3911 40 testis testis NN cord-028721-x6f26ahr 3911 41 show show NN cord-028721-x6f26ahr 3911 42 signifi signifi NNP cord-028721-x6f26ahr 3911 43 ca can MD cord-028721-x6f26ahr 3911 44 nt not RB cord-028721-x6f26ahr 3911 45 neurological neurological JJ cord-028721-x6f26ahr 3911 46 changes change NNS cord-028721-x6f26ahr 3912 1 Maternal maternal JJ cord-028721-x6f26ahr 3912 2 hormone hormone NN cord-028721-x6f26ahr 3912 3 levels level NNS cord-028721-x6f26ahr 3912 4 in in IN cord-028721-x6f26ahr 3912 5 early early JJ cord-028721-x6f26ahr 3912 6 gestation gestation NN cord-028721-x6f26ahr 3912 7 of of IN cord-028721-x6f26ahr 3912 8 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 3912 9 males male NNS cord-028721-x6f26ahr 3912 10 : : : cord-028721-x6f26ahr 3912 11 a a DT cord-028721-x6f26ahr 3912 12 case case NN cord-028721-x6f26ahr 3912 13 - - HYPH cord-028721-x6f26ahr 3912 14 control control NN cord-028721-x6f26ahr 3912 15 study study NN cord-028721-x6f26ahr 3912 16 The the DT cord-028721-x6f26ahr 3912 17 endocrinology endocrinology NN cord-028721-x6f26ahr 3912 18 of of IN cord-028721-x6f26ahr 3912 19 testicular testicular JJ cord-028721-x6f26ahr 3912 20 descent descent NN cord-028721-x6f26ahr 3912 21 Expression expression NN cord-028721-x6f26ahr 3912 22 of of IN cord-028721-x6f26ahr 3912 23 estrogen estrogen NN cord-028721-x6f26ahr 3912 24 receptor receptor NN cord-028721-x6f26ahr 3912 25 ESR1 ESR1 NNP cord-028721-x6f26ahr 3912 26 and and CC cord-028721-x6f26ahr 3912 27 its -PRON- PRP$ cord-028721-x6f26ahr 3912 28 46-kDa 46-kda CD cord-028721-x6f26ahr 3912 29 variant variant NN cord-028721-x6f26ahr 3912 30 in in IN cord-028721-x6f26ahr 3912 31 the the DT cord-028721-x6f26ahr 3912 32 gubernaculum gubernaculum NN cord-028721-x6f26ahr 3912 33 testis testis NN cord-028721-x6f26ahr 3912 34 Expression expression NN cord-028721-x6f26ahr 3912 35 of of IN cord-028721-x6f26ahr 3912 36 References reference NNS cord-028721-x6f26ahr 3912 37 children child NNS cord-028721-x6f26ahr 3912 38 and and CC cord-028721-x6f26ahr 3912 39 adults adult NNS cord-028721-x6f26ahr 3912 40 Spermatic Spermatic NNP cord-028721-x6f26ahr 3912 41 and and CC cord-028721-x6f26ahr 3912 42 peripheral peripheral JJ cord-028721-x6f26ahr 3912 43 plasma plasma NN cord-028721-x6f26ahr 3912 44 concentration concentration NN cord-028721-x6f26ahr 3912 45 of of IN cord-028721-x6f26ahr 3912 46 testosterone testosterone NN cord-028721-x6f26ahr 3912 47 and and CC cord-028721-x6f26ahr 3912 48 androstenedione androstenedione NN cord-028721-x6f26ahr 3912 49 in in IN cord-028721-x6f26ahr 3912 50 prepubertal prepubertal JJ cord-028721-x6f26ahr 3912 51 boys boy NNS cord-028721-x6f26ahr 3912 52 Pituitary Pituitary NNP cord-028721-x6f26ahr 3912 53 testicular testicular JJ cord-028721-x6f26ahr 3912 54 axis axis NN cord-028721-x6f26ahr 3912 55 during during IN cord-028721-x6f26ahr 3912 56 puberal puberal NNP cord-028721-x6f26ahr 3912 57 development development NN cord-028721-x6f26ahr 3912 58 Development Development NNP cord-028721-x6f26ahr 3912 59 of of IN cord-028721-x6f26ahr 3912 60 Leydig Leydig NNP cord-028721-x6f26ahr 3912 61 cells cell NNS cord-028721-x6f26ahr 3912 62 in in IN cord-028721-x6f26ahr 3912 63 the the DT cord-028721-x6f26ahr 3912 64 normal normal JJ cord-028721-x6f26ahr 3912 65 human human JJ cord-028721-x6f26ahr 3912 66 testis testis NN cord-028721-x6f26ahr 3912 67 . . . cord-028721-x6f26ahr 3913 1 A a DT cord-028721-x6f26ahr 3913 2 cytological cytological JJ cord-028721-x6f26ahr 3913 3 , , , cord-028721-x6f26ahr 3913 4 cytochemical cytochemical JJ cord-028721-x6f26ahr 3913 5 and and CC cord-028721-x6f26ahr 3913 6 quantitative quantitative JJ cord-028721-x6f26ahr 3913 7 study study NN cord-028721-x6f26ahr 3913 8 A a DT cord-028721-x6f26ahr 3913 9 quantitative quantitative JJ cord-028721-x6f26ahr 3913 10 morphology morphology NN cord-028721-x6f26ahr 3913 11 study study NN cord-028721-x6f26ahr 3913 12 of of IN cord-028721-x6f26ahr 3913 13 human human JJ cord-028721-x6f26ahr 3913 14 Leydig Leydig NNP cord-028721-x6f26ahr 3913 15 cells cell NNS cord-028721-x6f26ahr 3913 16 from from IN cord-028721-x6f26ahr 3913 17 birth birth NN cord-028721-x6f26ahr 3913 18 to to IN cord-028721-x6f26ahr 3913 19 adulthood adulthood NN cord-028721-x6f26ahr 3913 20 Testicular testicular JJ cord-028721-x6f26ahr 3913 21 volume volume NN cord-028721-x6f26ahr 3913 22 during during IN cord-028721-x6f26ahr 3913 23 adolescence adolescence NN cord-028721-x6f26ahr 3913 24 . . . cord-028721-x6f26ahr 3914 1 Cross cross JJ cord-028721-x6f26ahr 3914 2 - - JJ cord-028721-x6f26ahr 3914 3 sectional sectional JJ cord-028721-x6f26ahr 3914 4 and and CC cord-028721-x6f26ahr 3914 5 longitudinal longitudinal JJ cord-028721-x6f26ahr 3914 6 studies study NNS cord-028721-x6f26ahr 3915 1 Testicular testicular JJ cord-028721-x6f26ahr 3915 2 volumes volume NNS cord-028721-x6f26ahr 3915 3 of of IN cord-028721-x6f26ahr 3915 4 adolescent adolescent JJ cord-028721-x6f26ahr 3915 5 Clinical clinical JJ cord-028721-x6f26ahr 3915 6 measurement measurement NN cord-028721-x6f26ahr 3915 7 of of IN cord-028721-x6f26ahr 3915 8 the the DT cord-028721-x6f26ahr 3915 9 testes testis NNS cord-028721-x6f26ahr 3915 10 in in IN cord-028721-x6f26ahr 3915 11 boys boy NNS cord-028721-x6f26ahr 3915 12 and and CC cord-028721-x6f26ahr 3915 13 men man NNS cord-028721-x6f26ahr 3915 14 Testicular testicular JJ cord-028721-x6f26ahr 3915 15 histology histology NN cord-028721-x6f26ahr 3915 16 in in IN cord-028721-x6f26ahr 3915 17 fetuses fetus NNS cord-028721-x6f26ahr 3915 18 with with IN cord-028721-x6f26ahr 3915 19 the the DT cord-028721-x6f26ahr 3915 20 prune prune NN cord-028721-x6f26ahr 3915 21 belly belly NN cord-028721-x6f26ahr 3915 22 syndrome syndrome NN cord-028721-x6f26ahr 3915 23 and and CC cord-028721-x6f26ahr 3915 24 posterior posterior JJ cord-028721-x6f26ahr 3915 25 urethral urethral JJ cord-028721-x6f26ahr 3915 26 valves valve NNS cord-028721-x6f26ahr 3915 27 Proliferation proliferation NN cord-028721-x6f26ahr 3915 28 of of IN cord-028721-x6f26ahr 3915 29 Sertoli Sertoli NNP cord-028721-x6f26ahr 3915 30 cells cell NNS cord-028721-x6f26ahr 3915 31 during during IN cord-028721-x6f26ahr 3915 32 development development NN cord-028721-x6f26ahr 3915 33 of of IN cord-028721-x6f26ahr 3915 34 the the DT cord-028721-x6f26ahr 3915 35 human human JJ cord-028721-x6f26ahr 3915 36 testis testis NN cord-028721-x6f26ahr 3915 37 assessed assess VBN cord-028721-x6f26ahr 3915 38 by by IN cord-028721-x6f26ahr 3915 39 stereological stereological JJ cord-028721-x6f26ahr 3915 40 methods method NNS cord-028721-x6f26ahr 3916 1 Hyperplasia hyperplasia NN cord-028721-x6f26ahr 3916 2 and and CC cord-028721-x6f26ahr 3916 3 the the DT cord-028721-x6f26ahr 3916 4 immature immature JJ cord-028721-x6f26ahr 3916 5 appearance appearance NN cord-028721-x6f26ahr 3916 6 of of IN cord-028721-x6f26ahr 3916 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 3916 8 cells cell NNS cord-028721-x6f26ahr 3916 9 in in IN cord-028721-x6f26ahr 3916 10 primary primary JJ cord-028721-x6f26ahr 3916 11 testicular testicular JJ cord-028721-x6f26ahr 3916 12 disorders disorder NNS cord-028721-x6f26ahr 3916 13 Granular granular JJ cord-028721-x6f26ahr 3916 14 transformation transformation NN cord-028721-x6f26ahr 3916 15 of of IN cord-028721-x6f26ahr 3916 16 Sertoli Sertoli NNP cord-028721-x6f26ahr 3916 17 cells cell NNS cord-028721-x6f26ahr 3916 18 in in IN cord-028721-x6f26ahr 3916 19 testicular testicular JJ cord-028721-x6f26ahr 3916 20 disorders disorder NNS cord-028721-x6f26ahr 3917 1 A a DT cord-028721-x6f26ahr 3917 2 quantitative quantitative JJ cord-028721-x6f26ahr 3917 3 morphological morphological JJ cord-028721-x6f26ahr 3917 4 study study NN cord-028721-x6f26ahr 3917 5 of of IN cord-028721-x6f26ahr 3917 6 human human JJ cord-028721-x6f26ahr 3917 7 Leydig Leydig NNP cord-028721-x6f26ahr 3917 8 cells cell NNS cord-028721-x6f26ahr 3917 9 from from IN cord-028721-x6f26ahr 3917 10 birth birth NN cord-028721-x6f26ahr 3917 11 to to IN cord-028721-x6f26ahr 3917 12 adulthood adulthood NN cord-028721-x6f26ahr 3918 1 Congenital congenital JJ cord-028721-x6f26ahr 3918 2 Leydig Leydig NNP cord-028721-x6f26ahr 3918 3 cell cell NN cord-028721-x6f26ahr 3919 1 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3919 2 Morphologic morphologic JJ cord-028721-x6f26ahr 3919 3 anomalies anomaly NNS cord-028721-x6f26ahr 3919 4 in in IN cord-028721-x6f26ahr 3919 5 triploid triploid JJ cord-028721-x6f26ahr 3919 6 liveborn liveborn VBN cord-028721-x6f26ahr 3919 7 fetuses fetus NNS cord-028721-x6f26ahr 3920 1 Objective objective JJ cord-028721-x6f26ahr 3920 2 measurement measurement NN cord-028721-x6f26ahr 3920 3 of of IN cord-028721-x6f26ahr 3920 4 testicular testicular JJ cord-028721-x6f26ahr 3920 5 volume volume NN cord-028721-x6f26ahr 3920 6 by by IN cord-028721-x6f26ahr 3920 7 ultrasonography ultrasonography NN cord-028721-x6f26ahr 3920 8 : : : cord-028721-x6f26ahr 3920 9 evaluation evaluation NN cord-028721-x6f26ahr 3920 10 of of IN cord-028721-x6f26ahr 3920 11 the the DT cord-028721-x6f26ahr 3920 12 technique technique NN cord-028721-x6f26ahr 3920 13 and and CC cord-028721-x6f26ahr 3920 14 comparison comparison NN cord-028721-x6f26ahr 3920 15 with with IN cord-028721-x6f26ahr 3920 16 orchidometer orchidometer NN cord-028721-x6f26ahr 3920 17 estimates estimate VBZ cord-028721-x6f26ahr 3920 18 Ethnic ethnic JJ cord-028721-x6f26ahr 3920 19 differences difference NNS cord-028721-x6f26ahr 3920 20 . . . cord-028721-x6f26ahr 3921 1 Variation variation NN cord-028721-x6f26ahr 3921 2 in in IN cord-028721-x6f26ahr 3921 3 human human JJ cord-028721-x6f26ahr 3921 4 testis testis NN cord-028721-x6f26ahr 3921 5 size size NN cord-028721-x6f26ahr 3921 6 Testicular Testicular NNP cord-028721-x6f26ahr 3921 7 size size NN cord-028721-x6f26ahr 3921 8 : : : cord-028721-x6f26ahr 3921 9 The the DT cord-028721-x6f26ahr 3921 10 effects effect NNS cord-028721-x6f26ahr 3921 11 of of IN cord-028721-x6f26ahr 3921 12 ageing age VBG cord-028721-x6f26ahr 3921 13 , , , cord-028721-x6f26ahr 3921 14 malnutrition malnutrition NN cord-028721-x6f26ahr 3921 15 , , , cord-028721-x6f26ahr 3921 16 and and CC cord-028721-x6f26ahr 3921 17 illness illness NN cord-028721-x6f26ahr 3921 18 Testicular Testicular NNP cord-028721-x6f26ahr 3921 19 size size NN cord-028721-x6f26ahr 3921 20 : : : cord-028721-x6f26ahr 3921 21 assesment assesment JJ cord-028721-x6f26ahr 3921 22 and and CC cord-028721-x6f26ahr 3921 23 clinical clinical JJ cord-028721-x6f26ahr 3921 24 importance importance NN cord-028721-x6f26ahr 3921 25 Studies study NNS cord-028721-x6f26ahr 3921 26 of of IN cord-028721-x6f26ahr 3921 27 the the DT cord-028721-x6f26ahr 3921 28 participation participation NN cord-028721-x6f26ahr 3921 29 of of IN cord-028721-x6f26ahr 3921 30 the the DT cord-028721-x6f26ahr 3921 31 tunica tunica NNP cord-028721-x6f26ahr 3921 32 albuginea albuginea NNP cord-028721-x6f26ahr 3921 33 and and CC cord-028721-x6f26ahr 3921 34 rete rete NNP cord-028721-x6f26ahr 3921 35 testis testis NN cord-028721-x6f26ahr 3921 36 ( ( -LRB- cord-028721-x6f26ahr 3921 37 TA TA NNP cord-028721-x6f26ahr 3921 38 and and CC cord-028721-x6f26ahr 3921 39 RT RT NNP cord-028721-x6f26ahr 3921 40 ) ) -RRB- cord-028721-x6f26ahr 3921 41 in in IN cord-028721-x6f26ahr 3921 42 the the DT cord-028721-x6f26ahr 3921 43 quantitative quantitative JJ cord-028721-x6f26ahr 3921 44 structure structure NN cord-028721-x6f26ahr 3921 45 of of IN cord-028721-x6f26ahr 3921 46 human human JJ cord-028721-x6f26ahr 3921 47 testis testis NN cord-028721-x6f26ahr 3921 48 Postnatal postnatal JJ cord-028721-x6f26ahr 3921 49 development development NN cord-028721-x6f26ahr 3921 50 and and CC cord-028721-x6f26ahr 3921 51 differentiation differentiation NN cord-028721-x6f26ahr 3921 52 of of IN cord-028721-x6f26ahr 3921 53 contractile contractile JJ cord-028721-x6f26ahr 3921 54 cells cell NNS cord-028721-x6f26ahr 3921 55 within within IN cord-028721-x6f26ahr 3921 56 the the DT cord-028721-x6f26ahr 3921 57 rabbit rabbit NN cord-028721-x6f26ahr 3921 58 testis testis NN cord-028721-x6f26ahr 3922 1 The the DT cord-028721-x6f26ahr 3922 2 tunica tunica NNP cord-028721-x6f26ahr 3922 3 albuginea albuginea NN cord-028721-x6f26ahr 3922 4 of of IN cord-028721-x6f26ahr 3922 5 the the DT cord-028721-x6f26ahr 3922 6 human human JJ cord-028721-x6f26ahr 3922 7 testis testis NN cord-028721-x6f26ahr 3922 8 is be VBZ cord-028721-x6f26ahr 3922 9 characterized characterize VBN cord-028721-x6f26ahr 3922 10 by by IN cord-028721-x6f26ahr 3922 11 complex complex JJ cord-028721-x6f26ahr 3922 12 contraction contraction NN cord-028721-x6f26ahr 3922 13 and and CC cord-028721-x6f26ahr 3922 14 relaxation relaxation NN cord-028721-x6f26ahr 3922 15 activities activity NNS cord-028721-x6f26ahr 3922 16 regulated regulate VBN cord-028721-x6f26ahr 3922 17 by by IN cord-028721-x6f26ahr 3922 18 cyclic cyclic JJ cord-028721-x6f26ahr 3922 19 GMP GMP NNP cord-028721-x6f26ahr 3922 20 Histology Histology NNP cord-028721-x6f26ahr 3922 21 of of IN cord-028721-x6f26ahr 3922 22 the the DT cord-028721-x6f26ahr 3922 23 normal normal JJ cord-028721-x6f26ahr 3922 24 testis testis NN cord-028721-x6f26ahr 3923 1 A a DT cord-028721-x6f26ahr 3923 2 method method NN cord-028721-x6f26ahr 3923 3 for for IN cord-028721-x6f26ahr 3923 4 determining determine VBG cord-028721-x6f26ahr 3923 5 the the DT cord-028721-x6f26ahr 3923 6 relative relative JJ cord-028721-x6f26ahr 3923 7 total total JJ cord-028721-x6f26ahr 3923 8 lenght lenght NN cord-028721-x6f26ahr 3923 9 of of IN cord-028721-x6f26ahr 3923 10 the the DT cord-028721-x6f26ahr 3923 11 tubules tubule NNS cord-028721-x6f26ahr 3923 12 in in IN cord-028721-x6f26ahr 3923 13 the the DT cord-028721-x6f26ahr 3923 14 testis testis NN cord-028721-x6f26ahr 3924 1 The the DT cord-028721-x6f26ahr 3924 2 fi fi NNP cord-028721-x6f26ahr 3924 3 ne ne NNP cord-028721-x6f26ahr 3924 4 structure structure NN cord-028721-x6f26ahr 3924 5 of of IN cord-028721-x6f26ahr 3924 6 Sertoli Sertoli NNP cord-028721-x6f26ahr 3924 7 cells cell NNS cord-028721-x6f26ahr 3924 8 in in IN cord-028721-x6f26ahr 3924 9 the the DT cord-028721-x6f26ahr 3924 10 human human JJ cord-028721-x6f26ahr 3924 11 testis testis NN cord-028721-x6f26ahr 3925 1 Some some DT cord-028721-x6f26ahr 3925 2 observations observation NNS cord-028721-x6f26ahr 3925 3 on on IN cord-028721-x6f26ahr 3925 4 the the DT cord-028721-x6f26ahr 3925 5 fi fi NNP cord-028721-x6f26ahr 3925 6 ne ne NNP cord-028721-x6f26ahr 3925 7 structure structure NN cord-028721-x6f26ahr 3925 8 of of IN cord-028721-x6f26ahr 3925 9 the the DT cord-028721-x6f26ahr 3925 10 Sertoli sertoli JJ cord-028721-x6f26ahr 3925 11 cell cell NN cord-028721-x6f26ahr 3925 12 in in IN cord-028721-x6f26ahr 3925 13 the the DT cord-028721-x6f26ahr 3925 14 human human JJ cord-028721-x6f26ahr 3925 15 testis testis NN cord-028721-x6f26ahr 3925 16 On on IN cord-028721-x6f26ahr 3925 17 the the DT cord-028721-x6f26ahr 3925 18 morphology morphology NN cord-028721-x6f26ahr 3925 19 of of IN cord-028721-x6f26ahr 3925 20 the the DT cord-028721-x6f26ahr 3925 21 human human JJ cord-028721-x6f26ahr 3925 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 3925 23 cell cell NN cord-028721-x6f26ahr 3925 24 Organization Organization NNP cord-028721-x6f26ahr 3925 25 and and CC cord-028721-x6f26ahr 3925 26 morphogenesis morphogenesis NN cord-028721-x6f26ahr 3925 27 of of IN cord-028721-x6f26ahr 3925 28 the the DT cord-028721-x6f26ahr 3925 29 human human JJ cord-028721-x6f26ahr 3925 30 seminiferous seminiferous JJ cord-028721-x6f26ahr 3925 31 epithelium epithelium NN cord-028721-x6f26ahr 3926 1 The the DT cord-028721-x6f26ahr 3926 2 mammalian mammalian JJ cord-028721-x6f26ahr 3926 3 spermatozoon spermatozoon NN cord-028721-x6f26ahr 3926 4 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 3926 5 observations observation NNS cord-028721-x6f26ahr 3926 6 on on IN cord-028721-x6f26ahr 3926 7 nucleoli nucleoli NNP cord-028721-x6f26ahr 3926 8 and and CC cord-028721-x6f26ahr 3926 9 related related JJ cord-028721-x6f26ahr 3926 10 structures structure NNS cord-028721-x6f26ahr 3926 11 during during IN cord-028721-x6f26ahr 3926 12 human human JJ cord-028721-x6f26ahr 3926 13 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3926 14 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 3926 15 of of IN cord-028721-x6f26ahr 3926 16 the the DT cord-028721-x6f26ahr 3926 17 nucleus nucleus NN cord-028721-x6f26ahr 3926 18 of of IN cord-028721-x6f26ahr 3926 19 human human JJ cord-028721-x6f26ahr 3926 20 Sertoli Sertoli NNP cord-028721-x6f26ahr 3926 21 cells cell NNS cord-028721-x6f26ahr 3926 22 in in IN cord-028721-x6f26ahr 3926 23 normal normal JJ cord-028721-x6f26ahr 3926 24 and and CC cord-028721-x6f26ahr 3926 25 pathological pathological JJ cord-028721-x6f26ahr 3926 26 testes testis NNS cord-028721-x6f26ahr 3926 27 Cell cell NN cord-028721-x6f26ahr 3926 28 - - HYPH cord-028721-x6f26ahr 3926 29 cell cell NN cord-028721-x6f26ahr 3926 30 communication communication NN cord-028721-x6f26ahr 3926 31 in in IN cord-028721-x6f26ahr 3926 32 the the DT cord-028721-x6f26ahr 3926 33 testis testis NN cord-028721-x6f26ahr 3927 1 The the DT cord-028721-x6f26ahr 3927 2 fi fi NNP cord-028721-x6f26ahr 3927 3 ne ne NNP cord-028721-x6f26ahr 3927 4 structure structure NN cord-028721-x6f26ahr 3927 5 of of IN cord-028721-x6f26ahr 3927 6 the the DT cord-028721-x6f26ahr 3927 7 monkey monkey NN cord-028721-x6f26ahr 3927 8 ( ( -LRB- cord-028721-x6f26ahr 3927 9 Macaca macaca NN cord-028721-x6f26ahr 3927 10 ) ) -RRB- cord-028721-x6f26ahr 3928 1 Sertoli sertoli JJ cord-028721-x6f26ahr 3928 2 cell cell NN cord-028721-x6f26ahr 3928 3 and and CC cord-028721-x6f26ahr 3928 4 its -PRON- PRP$ cord-028721-x6f26ahr 3928 5 role role NN cord-028721-x6f26ahr 3928 6 in in IN cord-028721-x6f26ahr 3928 7 maintaining maintain VBG cord-028721-x6f26ahr 3928 8 the the DT cord-028721-x6f26ahr 3928 9 blood blood NN cord-028721-x6f26ahr 3928 10 - - HYPH cord-028721-x6f26ahr 3928 11 testis testis NN cord-028721-x6f26ahr 3928 12 barrier barrier NN cord-028721-x6f26ahr 3928 13 Electron Electron NNP cord-028721-x6f26ahr 3928 14 microscopic microscopic JJ cord-028721-x6f26ahr 3928 15 observations observation NNS cord-028721-x6f26ahr 3928 16 on on IN cord-028721-x6f26ahr 3928 17 the the DT cord-028721-x6f26ahr 3928 18 structural structural JJ cord-028721-x6f26ahr 3928 19 components component NNS cord-028721-x6f26ahr 3928 20 of of IN cord-028721-x6f26ahr 3928 21 the the DT cord-028721-x6f26ahr 3928 22 blood blood NN cord-028721-x6f26ahr 3928 23 testis testis NN cord-028721-x6f26ahr 3928 24 barrier barrier NN cord-028721-x6f26ahr 3928 25 Sertoli Sertoli NNP cord-028721-x6f26ahr 3928 26 cell cell NN cord-028721-x6f26ahr 3928 27 junctions junction NNS cord-028721-x6f26ahr 3928 28 : : : cord-028721-x6f26ahr 3928 29 morphological morphological JJ cord-028721-x6f26ahr 3928 30 and and CC cord-028721-x6f26ahr 3928 31 functional functional JJ cord-028721-x6f26ahr 3928 32 correlates correlate NNS cord-028721-x6f26ahr 3929 1 Morphological morphological JJ cord-028721-x6f26ahr 3929 2 and and CC cord-028721-x6f26ahr 3929 3 functional functional JJ cord-028721-x6f26ahr 3929 4 evidence evidence NN cord-028721-x6f26ahr 3929 5 for for IN cord-028721-x6f26ahr 3929 6 Sertoli sertoli JJ cord-028721-x6f26ahr 3929 7 - - HYPH cord-028721-x6f26ahr 3929 8 germ germ NN cord-028721-x6f26ahr 3929 9 cell cell NN cord-028721-x6f26ahr 3929 10 relationship relationship NN cord-028721-x6f26ahr 3930 1 The the DT cord-028721-x6f26ahr 3930 2 testis testis NN cord-028721-x6f26ahr 3930 3 Evidence evidence NN cord-028721-x6f26ahr 3930 4 that that IN cord-028721-x6f26ahr 3930 5 vinculin vinculin NNP cord-028721-x6f26ahr 3930 6 is be VBZ cord-028721-x6f26ahr 3930 7 codistributed codistribute VBN cord-028721-x6f26ahr 3930 8 with with IN cord-028721-x6f26ahr 3930 9 actin actin NN cord-028721-x6f26ahr 3930 10 bundles bundle NNS cord-028721-x6f26ahr 3930 11 in in IN cord-028721-x6f26ahr 3930 12 ectoplasmic ectoplasmic JJ cord-028721-x6f26ahr 3930 13 ( ( -LRB- cord-028721-x6f26ahr 3930 14 ' ' `` cord-028721-x6f26ahr 3930 15 junctional junctional JJ cord-028721-x6f26ahr 3930 16 ' ' '' cord-028721-x6f26ahr 3930 17 ) ) -RRB- cord-028721-x6f26ahr 3930 18 specializations specialization NNS cord-028721-x6f26ahr 3930 19 of of IN cord-028721-x6f26ahr 3930 20 mammalian mammalian JJ cord-028721-x6f26ahr 3930 21 Sertoli Sertoli NNP cord-028721-x6f26ahr 3930 22 cells cell NNS cord-028721-x6f26ahr 3930 23 Changes change NNS cord-028721-x6f26ahr 3930 24 in in IN cord-028721-x6f26ahr 3930 25 the the DT cord-028721-x6f26ahr 3930 26 lipid lipid NN cord-028721-x6f26ahr 3930 27 inclusion/ inclusion/ ADD cord-028721-x6f26ahr 3930 28 Sertoli sertoli JJ cord-028721-x6f26ahr 3930 29 cell cell NN cord-028721-x6f26ahr 3930 30 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3930 31 area area NN cord-028721-x6f26ahr 3930 32 ratio ratio NN cord-028721-x6f26ahr 3930 33 during during IN cord-028721-x6f26ahr 3930 34 the the DT cord-028721-x6f26ahr 3930 35 cycle cycle NN cord-028721-x6f26ahr 3930 36 of of IN cord-028721-x6f26ahr 3930 37 the the DT cord-028721-x6f26ahr 3930 38 human human JJ cord-028721-x6f26ahr 3930 39 seminiferous seminiferous JJ cord-028721-x6f26ahr 3930 40 epithelium epithelium NN cord-028721-x6f26ahr 3930 41 Fine fine JJ cord-028721-x6f26ahr 3930 42 structure structure NN cord-028721-x6f26ahr 3930 43 of of IN cord-028721-x6f26ahr 3930 44 the the DT cord-028721-x6f26ahr 3930 45 Sertoli sertoli JJ cord-028721-x6f26ahr 3930 46 cell cell NN cord-028721-x6f26ahr 3930 47 of of IN cord-028721-x6f26ahr 3930 48 the the DT cord-028721-x6f26ahr 3930 49 human human JJ cord-028721-x6f26ahr 3930 50 testis testis NN cord-028721-x6f26ahr 3930 51 Testicular testicular JJ cord-028721-x6f26ahr 3930 52 involution involution NN cord-028721-x6f26ahr 3930 53 in in IN cord-028721-x6f26ahr 3930 54 elderly elderly JJ cord-028721-x6f26ahr 3930 55 men man NNS cord-028721-x6f26ahr 3930 56 : : : cord-028721-x6f26ahr 3930 57 comparison comparison NN cord-028721-x6f26ahr 3930 58 of of IN cord-028721-x6f26ahr 3930 59 histologic histologic JJ cord-028721-x6f26ahr 3930 60 quantitative quantitative JJ cord-028721-x6f26ahr 3930 61 studies study NNS cord-028721-x6f26ahr 3930 62 with with IN cord-028721-x6f26ahr 3930 63 hormone hormone NN cord-028721-x6f26ahr 3930 64 patterns pattern NNS cord-028721-x6f26ahr 3930 65 Multinucleate Multinucleate NNP cord-028721-x6f26ahr 3930 66 Sertoli Sertoli NNP cord-028721-x6f26ahr 3930 67 cells cell NNS cord-028721-x6f26ahr 3930 68 in in IN cord-028721-x6f26ahr 3930 69 aged aged JJ cord-028721-x6f26ahr 3930 70 human human JJ cord-028721-x6f26ahr 3930 71 testes testis NNS cord-028721-x6f26ahr 3930 72 Infl infl IN cord-028721-x6f26ahr 3930 73 uence uence NN cord-028721-x6f26ahr 3930 74 of of IN cord-028721-x6f26ahr 3930 75 age age NN cord-028721-x6f26ahr 3930 76 on on IN cord-028721-x6f26ahr 3930 77 sperm sperm NN cord-028721-x6f26ahr 3930 78 production production NN cord-028721-x6f26ahr 3930 79 and and CC cord-028721-x6f26ahr 3930 80 testicular testicular JJ cord-028721-x6f26ahr 3930 81 weights weight NNS cord-028721-x6f26ahr 3930 82 in in IN cord-028721-x6f26ahr 3930 83 men man NNS cord-028721-x6f26ahr 3930 84 Localization Localization NNP cord-028721-x6f26ahr 3930 85 of of IN cord-028721-x6f26ahr 3930 86 folliclestimulating folliclestimulate VBG cord-028721-x6f26ahr 3930 87 hormone hormone NN cord-028721-x6f26ahr 3931 1 ( ( -LRB- cord-028721-x6f26ahr 3931 2 FSH FSH NNP cord-028721-x6f26ahr 3931 3 ) ) -RRB- cord-028721-x6f26ahr 3931 4 immunoreactivity immunoreactivity NN cord-028721-x6f26ahr 3931 5 and and CC cord-028721-x6f26ahr 3931 6 hormone hormone NN cord-028721-x6f26ahr 3931 7 receptor receptor NN cord-028721-x6f26ahr 3932 1 mRNA mrna NN cord-028721-x6f26ahr 3932 2 in in IN cord-028721-x6f26ahr 3932 3 testicular testicular JJ cord-028721-x6f26ahr 3932 4 tissue tissue NN cord-028721-x6f26ahr 3932 5 of of IN cord-028721-x6f26ahr 3932 6 infertile infertile JJ cord-028721-x6f26ahr 3932 7 men man NNS cord-028721-x6f26ahr 3932 8 Role role NN cord-028721-x6f26ahr 3932 9 of of IN cord-028721-x6f26ahr 3932 10 FSH fsh NN cord-028721-x6f26ahr 3932 11 in in IN cord-028721-x6f26ahr 3932 12 male male JJ cord-028721-x6f26ahr 3932 13 gonadal gonadal JJ cord-028721-x6f26ahr 3932 14 function function NN cord-028721-x6f26ahr 3933 1 Androgen androgen NN cord-028721-x6f26ahr 3933 2 receptor receptor NN cord-028721-x6f26ahr 3933 3 distribution distribution NN cord-028721-x6f26ahr 3933 4 in in IN cord-028721-x6f26ahr 3933 5 adult adult NN cord-028721-x6f26ahr 3933 6 human human JJ cord-028721-x6f26ahr 3933 7 testis testis NN cord-028721-x6f26ahr 3934 1 The the DT cord-028721-x6f26ahr 3934 2 paracrine paracrine JJ cord-028721-x6f26ahr 3934 3 role role NN cord-028721-x6f26ahr 3934 4 of of IN cord-028721-x6f26ahr 3934 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 3934 6 cells cell NNS cord-028721-x6f26ahr 3934 7 on on IN cord-028721-x6f26ahr 3934 8 Leydig Leydig NNP cord-028721-x6f26ahr 3934 9 cell cell NN cord-028721-x6f26ahr 3934 10 function function NN cord-028721-x6f26ahr 3935 1 Receptormediated receptormediate VBN cord-028721-x6f26ahr 3935 2 endocytosis endocytosis NN cord-028721-x6f26ahr 3935 3 of of IN cord-028721-x6f26ahr 3935 4 testicular testicular JJ cord-028721-x6f26ahr 3935 5 transferrin transferrin NN cord-028721-x6f26ahr 3935 6 by by IN cord-028721-x6f26ahr 3935 7 germinal germinal JJ cord-028721-x6f26ahr 3935 8 cells cell NNS cord-028721-x6f26ahr 3935 9 of of IN cord-028721-x6f26ahr 3935 10 the the DT cord-028721-x6f26ahr 3935 11 rat rat NN cord-028721-x6f26ahr 3935 12 testis testis NN cord-028721-x6f26ahr 3935 13 Regulation regulation NN cord-028721-x6f26ahr 3935 14 of of IN cord-028721-x6f26ahr 3935 15 inhibin inhibin NN cord-028721-x6f26ahr 3935 16 production production NN cord-028721-x6f26ahr 3935 17 in in IN cord-028721-x6f26ahr 3935 18 the the DT cord-028721-x6f26ahr 3935 19 human human JJ cord-028721-x6f26ahr 3935 20 male male NN cord-028721-x6f26ahr 3935 21 and and CC cord-028721-x6f26ahr 3935 22 its -PRON- PRP$ cord-028721-x6f26ahr 3935 23 clinical clinical JJ cord-028721-x6f26ahr 3935 24 applications application NNS cord-028721-x6f26ahr 3935 25 Human human JJ cord-028721-x6f26ahr 3935 26 testis testis NN cord-028721-x6f26ahr 3935 27 cytosol cytosol NN cord-028721-x6f26ahr 3936 1 an an DT cord-028721-x6f26ahr 3936 2 ovarian ovarian JJ cord-028721-x6f26ahr 3936 3 follicular follicular JJ cord-028721-x6f26ahr 3936 4 fl fl NNP cord-028721-x6f26ahr 3936 5 uid uid NNS cord-028721-x6f26ahr 3936 6 contain contain VBP cord-028721-x6f26ahr 3936 7 high high JJ cord-028721-x6f26ahr 3936 8 amounts amount NNS cord-028721-x6f26ahr 3936 9 of of IN cord-028721-x6f26ahr 3936 10 interleukin-1-like interleukin-1-like NNP cord-028721-x6f26ahr 3936 11 factor(s factor(s NNP cord-028721-x6f26ahr 3936 12 ) ) -RRB- cord-028721-x6f26ahr 3937 1 Cell cell NN cord-028721-x6f26ahr 3937 2 interactions interaction NNS cord-028721-x6f26ahr 3937 3 during during IN cord-028721-x6f26ahr 3937 4 the the DT cord-028721-x6f26ahr 3937 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 3937 6 epithelial epithelial JJ cord-028721-x6f26ahr 3937 7 cycle cycle NN cord-028721-x6f26ahr 3937 8 Quantitative quantitative JJ cord-028721-x6f26ahr 3937 9 differences difference NNS cord-028721-x6f26ahr 3937 10 between between IN cord-028721-x6f26ahr 3937 11 variants variant NNS cord-028721-x6f26ahr 3937 12 of of IN cord-028721-x6f26ahr 3937 13 A a DT cord-028721-x6f26ahr 3937 14 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3937 15 in in IN cord-028721-x6f26ahr 3937 16 man man NN cord-028721-x6f26ahr 3938 1 The the DT cord-028721-x6f26ahr 3938 2 ultrastructure ultrastructure NN cord-028721-x6f26ahr 3938 3 of of IN cord-028721-x6f26ahr 3938 4 the the DT cord-028721-x6f26ahr 3938 5 four four CD cord-028721-x6f26ahr 3938 6 types type NNS cord-028721-x6f26ahr 3938 7 of of IN cord-028721-x6f26ahr 3938 8 human human JJ cord-028721-x6f26ahr 3938 9 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3938 10 Decrease decrease NN cord-028721-x6f26ahr 3938 11 in in IN cord-028721-x6f26ahr 3938 12 the the DT cord-028721-x6f26ahr 3938 13 number number NN cord-028721-x6f26ahr 3938 14 of of IN cord-028721-x6f26ahr 3938 15 Ap Ap NNP cord-028721-x6f26ahr 3938 16 and and CC cord-028721-x6f26ahr 3938 17 Ad Ad NNP cord-028721-x6f26ahr 3938 18 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3938 19 and and CC cord-028721-x6f26ahr 3938 20 the the DT cord-028721-x6f26ahr 3938 21 Ap Ap NNP cord-028721-x6f26ahr 3938 22 / / SYM cord-028721-x6f26ahr 3938 23 Ad ad NN cord-028721-x6f26ahr 3938 24 ratio ratio NN cord-028721-x6f26ahr 3938 25 with with IN cord-028721-x6f26ahr 3938 26 advancing advance VBG cord-028721-x6f26ahr 3938 27 age age NN cord-028721-x6f26ahr 3938 28 Quantifi Quantifi NNP cord-028721-x6f26ahr 3938 29 cation cation NN cord-028721-x6f26ahr 3938 30 of of IN cord-028721-x6f26ahr 3938 31 cell cell NN cord-028721-x6f26ahr 3938 32 types type NNS cord-028721-x6f26ahr 3938 33 throughout throughout IN cord-028721-x6f26ahr 3938 34 the the DT cord-028721-x6f26ahr 3938 35 cycle cycle NN cord-028721-x6f26ahr 3938 36 of of IN cord-028721-x6f26ahr 3938 37 the the DT cord-028721-x6f26ahr 3938 38 human human JJ cord-028721-x6f26ahr 3938 39 seminiferous seminiferous JJ cord-028721-x6f26ahr 3938 40 epithelium epithelium NN cord-028721-x6f26ahr 3938 41 and and CC cord-028721-x6f26ahr 3938 42 their -PRON- PRP$ cord-028721-x6f26ahr 3938 43 DNA dna NN cord-028721-x6f26ahr 3938 44 content content NN cord-028721-x6f26ahr 3938 45 Normal normal JJ cord-028721-x6f26ahr 3938 46 and and CC cord-028721-x6f26ahr 3938 47 abnormal abnormal JJ cord-028721-x6f26ahr 3938 48 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3938 49 in in IN cord-028721-x6f26ahr 3938 50 the the DT cord-028721-x6f26ahr 3938 51 human human JJ cord-028721-x6f26ahr 3938 52 testis testis NN cord-028721-x6f26ahr 3938 53 Development Development NNP cord-028721-x6f26ahr 3938 54 of of IN cord-028721-x6f26ahr 3938 55 the the DT cord-028721-x6f26ahr 3938 56 endoplasmic endoplasmic NN cord-028721-x6f26ahr 3938 57 reticulum reticulum NN cord-028721-x6f26ahr 3938 58 during during IN cord-028721-x6f26ahr 3938 59 human human JJ cord-028721-x6f26ahr 3938 60 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3938 61 Kinetics Kinetics NNP cord-028721-x6f26ahr 3938 62 of of IN cord-028721-x6f26ahr 3938 63 the the DT cord-028721-x6f26ahr 3938 64 germinal germinal JJ cord-028721-x6f26ahr 3938 65 epithelium epithelium NN cord-028721-x6f26ahr 3938 66 in in IN cord-028721-x6f26ahr 3938 67 man man NN cord-028721-x6f26ahr 3938 68 Atlas Atlas NNP cord-028721-x6f26ahr 3938 69 of of IN cord-028721-x6f26ahr 3938 70 human human JJ cord-028721-x6f26ahr 3938 71 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3938 72 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 3938 73 features feature VBZ cord-028721-x6f26ahr 3938 74 of of IN cord-028721-x6f26ahr 3938 75 human human JJ cord-028721-x6f26ahr 3938 76 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 3938 77 Morphogenetic morphogenetic JJ cord-028721-x6f26ahr 3938 78 factors factor NNS cord-028721-x6f26ahr 3938 79 infl infl VBP cord-028721-x6f26ahr 3938 80 uencing uence VBG cord-028721-x6f26ahr 3938 81 the the DT cord-028721-x6f26ahr 3938 82 shape shape NN cord-028721-x6f26ahr 3938 83 of of IN cord-028721-x6f26ahr 3938 84 the the DT cord-028721-x6f26ahr 3938 85 sperm sperm NN cord-028721-x6f26ahr 3938 86 head head NN cord-028721-x6f26ahr 3939 1 The the DT cord-028721-x6f26ahr 3939 2 fi fi NNP cord-028721-x6f26ahr 3939 3 ne ne NNP cord-028721-x6f26ahr 3939 4 structure structure NN cord-028721-x6f26ahr 3939 5 and and CC cord-028721-x6f26ahr 3939 6 development development NN cord-028721-x6f26ahr 3939 7 of of IN cord-028721-x6f26ahr 3939 8 the the DT cord-028721-x6f26ahr 3939 9 neck neck NN cord-028721-x6f26ahr 3939 10 region region NN cord-028721-x6f26ahr 3939 11 of of IN cord-028721-x6f26ahr 3939 12 the the DT cord-028721-x6f26ahr 3939 13 mammalian mammalian JJ cord-028721-x6f26ahr 3939 14 spermatozoon spermatozoon NN cord-028721-x6f26ahr 3939 15 Morphogenesis Morphogenesis NNP cord-028721-x6f26ahr 3939 16 and and CC cord-028721-x6f26ahr 3939 17 fate fate NN cord-028721-x6f26ahr 3939 18 of of IN cord-028721-x6f26ahr 3939 19 the the DT cord-028721-x6f26ahr 3939 20 residual residual JJ cord-028721-x6f26ahr 3939 21 body body NN cord-028721-x6f26ahr 3939 22 in in IN cord-028721-x6f26ahr 3939 23 human human JJ cord-028721-x6f26ahr 3939 24 spermiogenesis spermiogenesis NN cord-028721-x6f26ahr 3940 1 The the DT cord-028721-x6f26ahr 3940 2 phagocytic phagocytic JJ cord-028721-x6f26ahr 3940 3 function function NN cord-028721-x6f26ahr 3940 4 of of IN cord-028721-x6f26ahr 3940 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 3940 6 cells cell NNS cord-028721-x6f26ahr 3940 7 . . . cord-028721-x6f26ahr 3941 1 A a DT cord-028721-x6f26ahr 3941 2 morphological morphological JJ cord-028721-x6f26ahr 3941 3 , , , cord-028721-x6f26ahr 3941 4 biochemical biochemical JJ cord-028721-x6f26ahr 3941 5 , , , cord-028721-x6f26ahr 3941 6 and and CC cord-028721-x6f26ahr 3941 7 endocrinological endocrinological JJ cord-028721-x6f26ahr 3941 8 study study NN cord-028721-x6f26ahr 3941 9 of of IN cord-028721-x6f26ahr 3941 10 lysosomes lysosome NNS cord-028721-x6f26ahr 3941 11 and and CC cord-028721-x6f26ahr 3941 12 acid acid NN cord-028721-x6f26ahr 3941 13 phosphatase phosphatase NN cord-028721-x6f26ahr 3941 14 localization localization NN cord-028721-x6f26ahr 3941 15 in in IN cord-028721-x6f26ahr 3941 16 the the DT cord-028721-x6f26ahr 3941 17 rat rat NN cord-028721-x6f26ahr 3941 18 testis testis NN cord-028721-x6f26ahr 3941 19 Renewal Renewal NNP cord-028721-x6f26ahr 3941 20 of of IN cord-028721-x6f26ahr 3941 21 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3941 22 in in IN cord-028721-x6f26ahr 3941 23 man man NN cord-028721-x6f26ahr 3941 24 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 3941 25 observations observation NNS cord-028721-x6f26ahr 3941 26 on on IN cord-028721-x6f26ahr 3941 27 the the DT cord-028721-x6f26ahr 3941 28 differentiation differentiation NN cord-028721-x6f26ahr 3941 29 of of IN cord-028721-x6f26ahr 3941 30 spermatids spermatid NNS cord-028721-x6f26ahr 3941 31 in in IN cord-028721-x6f26ahr 3941 32 man man NN cord-028721-x6f26ahr 3942 1 Further further JJ cord-028721-x6f26ahr 3942 2 observations observation NNS cord-028721-x6f26ahr 3942 3 on on IN cord-028721-x6f26ahr 3942 4 the the DT cord-028721-x6f26ahr 3942 5 numbers number NNS cord-028721-x6f26ahr 3942 6 of of IN cord-028721-x6f26ahr 3942 7 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 3942 8 , , , cord-028721-x6f26ahr 3942 9 spermatocytes spermatocytes NNP cord-028721-x6f26ahr 3942 10 and and CC cord-028721-x6f26ahr 3942 11 spermatids spermatid NNS cord-028721-x6f26ahr 3942 12 connected connect VBN cord-028721-x6f26ahr 3942 13 by by IN cord-028721-x6f26ahr 3942 14 intercellular intercellular JJ cord-028721-x6f26ahr 3942 15 bridges bridge NNS cord-028721-x6f26ahr 3942 16 in in IN cord-028721-x6f26ahr 3942 17 the the DT cord-028721-x6f26ahr 3942 18 mammalian mammalian JJ cord-028721-x6f26ahr 3942 19 testis testis NN cord-028721-x6f26ahr 3942 20 Evidence evidence NN cord-028721-x6f26ahr 3942 21 of of IN cord-028721-x6f26ahr 3942 22 a a DT cord-028721-x6f26ahr 3942 23 wave wave NN cord-028721-x6f26ahr 3942 24 of of IN cord-028721-x6f26ahr 3942 25 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3942 26 in in IN cord-028721-x6f26ahr 3942 27 the the DT cord-028721-x6f26ahr 3942 28 human human JJ cord-028721-x6f26ahr 3942 29 testis testis NN cord-028721-x6f26ahr 3942 30 Computeraided Computeraided NNP cord-028721-x6f26ahr 3942 31 threedimensional threedimensional JJ cord-028721-x6f26ahr 3942 32 reconstructions reconstruction NNS cord-028721-x6f26ahr 3942 33 of of IN cord-028721-x6f26ahr 3942 34 the the DT cord-028721-x6f26ahr 3942 35 arrangement arrangement NN cord-028721-x6f26ahr 3942 36 of of IN cord-028721-x6f26ahr 3942 37 primary primary JJ cord-028721-x6f26ahr 3942 38 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 3942 39 in in IN cord-028721-x6f26ahr 3942 40 human human JJ cord-028721-x6f26ahr 3942 41 seminiferous seminiferous JJ cord-028721-x6f26ahr 3942 42 tubules tubule NNS cord-028721-x6f26ahr 3943 1 The the DT cord-028721-x6f26ahr 3943 2 cycle cycle NN cord-028721-x6f26ahr 3943 3 of of IN cord-028721-x6f26ahr 3943 4 the the DT cord-028721-x6f26ahr 3943 5 seminiferous seminiferous JJ cord-028721-x6f26ahr 3943 6 epithelium epithelium NN cord-028721-x6f26ahr 3943 7 in in IN cord-028721-x6f26ahr 3943 8 man man NN cord-028721-x6f26ahr 3943 9 Morphometrical Morphometrical NNP cord-028721-x6f26ahr 3943 10 analysis analysis NN cord-028721-x6f26ahr 3943 11 of of IN cord-028721-x6f26ahr 3943 12 Sertoli sertoli JJ cord-028721-x6f26ahr 3943 13 cell cell NN cord-028721-x6f26ahr 3943 14 ultrastructure ultrastructure NN cord-028721-x6f26ahr 3943 15 during during IN cord-028721-x6f26ahr 3943 16 the the DT cord-028721-x6f26ahr 3943 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 3943 18 epithelial epithelial JJ cord-028721-x6f26ahr 3943 19 cycle cycle NN cord-028721-x6f26ahr 3943 20 in in IN cord-028721-x6f26ahr 3943 21 rats rat NNS cord-028721-x6f26ahr 3943 22 Stage stage NN cord-028721-x6f26ahr 3943 23 - - HYPH cord-028721-x6f26ahr 3943 24 specifi specifi NN cord-028721-x6f26ahr 3943 25 c c NN cord-028721-x6f26ahr 3943 26 signals signal NNS cord-028721-x6f26ahr 3943 27 in in IN cord-028721-x6f26ahr 3943 28 germ germ NN cord-028721-x6f26ahr 3943 29 line line NN cord-028721-x6f26ahr 3943 30 differentiation differentiation NN cord-028721-x6f26ahr 3943 31 control control NN cord-028721-x6f26ahr 3943 32 of of IN cord-028721-x6f26ahr 3943 33 Sertoli Sertoli NNP cord-028721-x6f26ahr 3943 34 cell cell NN cord-028721-x6f26ahr 3943 35 phagocytic phagocytic NN cord-028721-x6f26ahr 3943 36 activity activity NN cord-028721-x6f26ahr 3943 37 by by IN cord-028721-x6f26ahr 3943 38 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 3943 39 cells cell NNS cord-028721-x6f26ahr 3943 40 Changes change NNS cord-028721-x6f26ahr 3943 41 in in IN cord-028721-x6f26ahr 3943 42 the the DT cord-028721-x6f26ahr 3943 43 lipid lipid NN cord-028721-x6f26ahr 3943 44 inclusions/ inclusions/ CD cord-028721-x6f26ahr 3943 45 Sertoli sertoli JJ cord-028721-x6f26ahr 3943 46 cell cell NN cord-028721-x6f26ahr 3943 47 cytoplasm cytoplasm NN cord-028721-x6f26ahr 3943 48 area area NN cord-028721-x6f26ahr 3943 49 ratio ratio NN cord-028721-x6f26ahr 3943 50 during during IN cord-028721-x6f26ahr 3943 51 the the DT cord-028721-x6f26ahr 3943 52 cycle cycle NN cord-028721-x6f26ahr 3943 53 of of IN cord-028721-x6f26ahr 3943 54 the the DT cord-028721-x6f26ahr 3943 55 Sertoli sertoli JJ cord-028721-x6f26ahr 3943 56 cell cell NN cord-028721-x6f26ahr 3943 57 of of IN cord-028721-x6f26ahr 3943 58 the the DT cord-028721-x6f26ahr 3943 59 human human JJ cord-028721-x6f26ahr 3943 60 seminiferous seminiferous JJ cord-028721-x6f26ahr 3943 61 epithelium epithelium NN cord-028721-x6f26ahr 3943 62 Interaction Interaction NNP cord-028721-x6f26ahr 3943 63 between between IN cord-028721-x6f26ahr 3943 64 germ germ NN cord-028721-x6f26ahr 3943 65 cells cell NNS cord-028721-x6f26ahr 3943 66 and and CC cord-028721-x6f26ahr 3943 67 Sertoli sertoli JJ cord-028721-x6f26ahr 3943 68 cells cell NNS cord-028721-x6f26ahr 3943 69 in in IN cord-028721-x6f26ahr 3943 70 the the DT cord-028721-x6f26ahr 3943 71 testis testis NN cord-028721-x6f26ahr 3943 72 Apoptosis apoptosis NN cord-028721-x6f26ahr 3943 73 of of IN cord-028721-x6f26ahr 3943 74 male male JJ cord-028721-x6f26ahr 3943 75 germ germ NN cord-028721-x6f26ahr 3943 76 cells cell NNS cord-028721-x6f26ahr 3943 77 , , , cord-028721-x6f26ahr 3944 1 a a DT cord-028721-x6f26ahr 3944 2 generalized generalized JJ cord-028721-x6f26ahr 3944 3 or or CC cord-028721-x6f26ahr 3944 4 a a DT cord-028721-x6f26ahr 3944 5 cell cell NN cord-028721-x6f26ahr 3944 6 typespecifi typespecifi NN cord-028721-x6f26ahr 3944 7 c c NN cord-028721-x6f26ahr 3944 8 phenomenon phenomenon NN cord-028721-x6f26ahr 3944 9 ? ? . cord-028721-x6f26ahr 3945 1 Ultrastructure ultrastructure JJ cord-028721-x6f26ahr 3945 2 and and CC cord-028721-x6f26ahr 3945 3 function function NN cord-028721-x6f26ahr 3945 4 of of IN cord-028721-x6f26ahr 3945 5 the the DT cord-028721-x6f26ahr 3945 6 lamina lamina JJ cord-028721-x6f26ahr 3945 7 propia propia NNP cord-028721-x6f26ahr 3945 8 of of IN cord-028721-x6f26ahr 3945 9 mammalian mammalian JJ cord-028721-x6f26ahr 3945 10 seminiferous seminiferous JJ cord-028721-x6f26ahr 3945 11 tubules tubule NNS cord-028721-x6f26ahr 3946 1 The the DT cord-028721-x6f26ahr 3946 2 peritubular peritubular JJ cord-028721-x6f26ahr 3946 3 tissue tissue NN cord-028721-x6f26ahr 3946 4 in in IN cord-028721-x6f26ahr 3946 5 the the DT cord-028721-x6f26ahr 3946 6 normal normal JJ cord-028721-x6f26ahr 3946 7 and and CC cord-028721-x6f26ahr 3946 8 pathological pathological JJ cord-028721-x6f26ahr 3946 9 human human JJ cord-028721-x6f26ahr 3946 10 testis testis NN cord-028721-x6f26ahr 3946 11 : : : cord-028721-x6f26ahr 3946 12 an an DT cord-028721-x6f26ahr 3946 13 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 3946 14 study study NN cord-028721-x6f26ahr 3946 15 Basement Basement NNP cord-028721-x6f26ahr 3946 16 membrane membrane NN cord-028721-x6f26ahr 3946 17 regulation regulation NN cord-028721-x6f26ahr 3946 18 of of IN cord-028721-x6f26ahr 3946 19 Sertoli Sertoli NNP cord-028721-x6f26ahr 3946 20 cells cell NNS cord-028721-x6f26ahr 3947 1 The the DT cord-028721-x6f26ahr 3947 2 lamina lamina JJ cord-028721-x6f26ahr 3947 3 propia propia NN cord-028721-x6f26ahr 3947 4 of of IN cord-028721-x6f26ahr 3947 5 vertebrate vertebrate JJ cord-028721-x6f26ahr 3947 6 seminiferous seminiferous JJ cord-028721-x6f26ahr 3947 7 tubules tubule NNS cord-028721-x6f26ahr 3947 8 : : : cord-028721-x6f26ahr 3948 1 A a DT cord-028721-x6f26ahr 3948 2 comparative comparative JJ cord-028721-x6f26ahr 3948 3 light light NN cord-028721-x6f26ahr 3948 4 and and CC cord-028721-x6f26ahr 3948 5 electron electron NN cord-028721-x6f26ahr 3948 6 microscopic microscopic JJ cord-028721-x6f26ahr 3948 7 investigation investigation NN cord-028721-x6f26ahr 3948 8 Contractile Contractile NNP cord-028721-x6f26ahr 3948 9 cells cell NNS cord-028721-x6f26ahr 3948 10 in in IN cord-028721-x6f26ahr 3948 11 human human JJ cord-028721-x6f26ahr 3948 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 3948 13 tubules tubule NNS cord-028721-x6f26ahr 3949 1 Peritubular Peritubular NNP cord-028721-x6f26ahr 3949 2 myoid myoid JJ cord-028721-x6f26ahr 3949 3 cells cell NNS cord-028721-x6f26ahr 3949 4 of of IN cord-028721-x6f26ahr 3949 5 human human NN cord-028721-x6f26ahr 3949 6 and and CC cord-028721-x6f26ahr 3949 7 rat rat NN cord-028721-x6f26ahr 3949 8 testis testis NN cord-028721-x6f26ahr 3949 9 are be VBP cord-028721-x6f26ahr 3949 10 smooth smooth JJ cord-028721-x6f26ahr 3949 11 muscle muscle NN cord-028721-x6f26ahr 3949 12 cells cell NNS cord-028721-x6f26ahr 3949 13 that that WDT cord-028721-x6f26ahr 3949 14 contain contain VBP cord-028721-x6f26ahr 3949 15 desmin desmin NN cord-028721-x6f26ahr 3949 16 - - HYPH cord-028721-x6f26ahr 3949 17 type type NN cord-028721-x6f26ahr 3949 18 intermediate intermediate NN cord-028721-x6f26ahr 3949 19 fi fi NN cord-028721-x6f26ahr 3950 1 laments lament VBZ cord-028721-x6f26ahr 3950 2 Elastic elastic JJ cord-028721-x6f26ahr 3950 3 tissue tissue NN cord-028721-x6f26ahr 3950 4 in in IN cord-028721-x6f26ahr 3950 5 the the DT cord-028721-x6f26ahr 3950 6 limiting limit VBG cord-028721-x6f26ahr 3950 7 membrane membrane NN cord-028721-x6f26ahr 3950 8 of of IN cord-028721-x6f26ahr 3950 9 the the DT cord-028721-x6f26ahr 3950 10 human human JJ cord-028721-x6f26ahr 3950 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 3950 12 tubules tubule NNS cord-028721-x6f26ahr 3951 1 The the DT cord-028721-x6f26ahr 3951 2 biology biology NN cord-028721-x6f26ahr 3951 3 of of IN cord-028721-x6f26ahr 3951 4 myofi myofi NNP cord-028721-x6f26ahr 3951 5 broblasts broblasts NNP cord-028721-x6f26ahr 3951 6 Evidence evidence NN cord-028721-x6f26ahr 3951 7 for for IN cord-028721-x6f26ahr 3951 8 contractility contractility NN cord-028721-x6f26ahr 3951 9 of of IN cord-028721-x6f26ahr 3951 10 the the DT cord-028721-x6f26ahr 3951 11 human human JJ cord-028721-x6f26ahr 3951 12 seminiferous seminiferous JJ cord-028721-x6f26ahr 3951 13 tubule tubule NN cord-028721-x6f26ahr 3951 14 confi confi NNP cord-028721-x6f26ahr 3951 15 rmed rme VBN cord-028721-x6f26ahr 3951 16 by by IN cord-028721-x6f26ahr 3951 17 its -PRON- PRP$ cord-028721-x6f26ahr 3951 18 response response NN cord-028721-x6f26ahr 3951 19 to to IN cord-028721-x6f26ahr 3951 20 noradrenaline noradrenaline NN cord-028721-x6f26ahr 3951 21 and and CC cord-028721-x6f26ahr 3951 22 acetylcholine acetylcholine NN cord-028721-x6f26ahr 3951 23 Agerelated Agerelated NNP cord-028721-x6f26ahr 3951 24 variations variation NNS cord-028721-x6f26ahr 3951 25 in in IN cord-028721-x6f26ahr 3951 26 seminiferous seminiferous JJ cord-028721-x6f26ahr 3951 27 tubules tubule NNS cord-028721-x6f26ahr 3951 28 in in IN cord-028721-x6f26ahr 3951 29 men man NNS cord-028721-x6f26ahr 3951 30 . . . cord-028721-x6f26ahr 3952 1 A a DT cord-028721-x6f26ahr 3952 2 stereologic stereologic JJ cord-028721-x6f26ahr 3952 3 evaluation evaluation NN cord-028721-x6f26ahr 3952 4 Distribution distribution NN cord-028721-x6f26ahr 3952 5 and and CC cord-028721-x6f26ahr 3952 6 role role NN cord-028721-x6f26ahr 3952 7 of of IN cord-028721-x6f26ahr 3952 8 CD34-positive cd34-positive CD cord-028721-x6f26ahr 3952 9 stromal stromal NN cord-028721-x6f26ahr 3952 10 cells cell NNS cord-028721-x6f26ahr 3952 11 and and CC cord-028721-x6f26ahr 3952 12 myofi myofi NNP cord-028721-x6f26ahr 3952 13 broblasts broblasts NNP cord-028721-x6f26ahr 3952 14 in in IN cord-028721-x6f26ahr 3952 15 human human JJ cord-028721-x6f26ahr 3952 16 normal normal JJ cord-028721-x6f26ahr 3952 17 testicular testicular JJ cord-028721-x6f26ahr 3952 18 stroma stroma NN cord-028721-x6f26ahr 3952 19 Giant Giant NNP cord-028721-x6f26ahr 3952 20 interstitial interstitial JJ cord-028721-x6f26ahr 3952 21 cells cell NNS cord-028721-x6f26ahr 3952 22 and and CC cord-028721-x6f26ahr 3952 23 extraparenchimal extraparenchimal JJ cord-028721-x6f26ahr 3952 24 interstitial interstitial JJ cord-028721-x6f26ahr 3952 25 cells cell NNS cord-028721-x6f26ahr 3952 26 of of IN cord-028721-x6f26ahr 3952 27 the the DT cord-028721-x6f26ahr 3952 28 human human JJ cord-028721-x6f26ahr 3952 29 testis testis NN cord-028721-x6f26ahr 3952 30 Morphological morphological JJ cord-028721-x6f26ahr 3952 31 relationship relationship NN cord-028721-x6f26ahr 3952 32 between between IN cord-028721-x6f26ahr 3952 33 testicular testicular JJ cord-028721-x6f26ahr 3952 34 nerves nerve NNS cord-028721-x6f26ahr 3952 35 and and CC cord-028721-x6f26ahr 3952 36 Leydig leydig NN cord-028721-x6f26ahr 3952 37 cells cell NNS cord-028721-x6f26ahr 3952 38 in in IN cord-028721-x6f26ahr 3953 1 man man NN cord-028721-x6f26ahr 3953 2 Sertoli Sertoli NNP cord-028721-x6f26ahr 3953 3 cells cell NNS cord-028721-x6f26ahr 3953 4 and and CC cord-028721-x6f26ahr 3953 5 Leydig leydig NN cord-028721-x6f26ahr 3953 6 cells cell NNS cord-028721-x6f26ahr 3953 7 in in IN cord-028721-x6f26ahr 3953 8 man man NN cord-028721-x6f26ahr 3953 9 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 3953 10 of of IN cord-028721-x6f26ahr 3953 11 Leydig Leydig NNP cord-028721-x6f26ahr 3953 12 cells cell NNS cord-028721-x6f26ahr 3953 13 in in IN cord-028721-x6f26ahr 3953 14 human human JJ cord-028721-x6f26ahr 3953 15 ageins agein NNS cord-028721-x6f26ahr 3953 16 testes testis NNS cord-028721-x6f26ahr 3953 17 Neuron Neuron NNP cord-028721-x6f26ahr 3953 18 - - HYPH cord-028721-x6f26ahr 3953 19 specifi specifi NNP cord-028721-x6f26ahr 3953 20 c c NN cord-028721-x6f26ahr 3953 21 enolase enolase NN cord-028721-x6f26ahr 3953 22 - - HYPH cord-028721-x6f26ahr 3953 23 like like JJ cord-028721-x6f26ahr 3953 24 inmunoreactivity inmunoreactivity NN cord-028721-x6f26ahr 3953 25 in in IN cord-028721-x6f26ahr 3953 26 human human JJ cord-028721-x6f26ahr 3953 27 Leydig Leydig NNP cord-028721-x6f26ahr 3953 28 cells cell NNS cord-028721-x6f26ahr 3954 1 Relaxin relaxin NN cord-028721-x6f26ahr 3954 2 - - HYPH cord-028721-x6f26ahr 3954 3 like like JJ cord-028721-x6f26ahr 3954 4 factor factor NN cord-028721-x6f26ahr 3954 5 : : : cord-028721-x6f26ahr 3954 6 a a DT cord-028721-x6f26ahr 3954 7 highly highly RB cord-028721-x6f26ahr 3954 8 specifi specifi JJ cord-028721-x6f26ahr 3954 9 c c NN cord-028721-x6f26ahr 3954 10 and and CC cord-028721-x6f26ahr 3954 11 constitutive constitutive JJ cord-028721-x6f26ahr 3954 12 new new JJ cord-028721-x6f26ahr 3954 13 marker marker NN cord-028721-x6f26ahr 3954 14 for for IN cord-028721-x6f26ahr 3954 15 Leydig Leydig NNP cord-028721-x6f26ahr 3954 16 cells cell NNS cord-028721-x6f26ahr 3954 17 in in IN cord-028721-x6f26ahr 3954 18 the the DT cord-028721-x6f26ahr 3954 19 human human JJ cord-028721-x6f26ahr 3954 20 testis testis NN cord-028721-x6f26ahr 3954 21 Ghrelin Ghrelin NNP cord-028721-x6f26ahr 3954 22 and and CC cord-028721-x6f26ahr 3954 23 reproduction reproduction NN cord-028721-x6f26ahr 3954 24 : : : cord-028721-x6f26ahr 3954 25 a a DT cord-028721-x6f26ahr 3954 26 novel novel JJ cord-028721-x6f26ahr 3954 27 signal signal NN cord-028721-x6f26ahr 3954 28 linking link VBG cord-028721-x6f26ahr 3954 29 energy energy NN cord-028721-x6f26ahr 3954 30 status status NN cord-028721-x6f26ahr 3954 31 and and CC cord-028721-x6f26ahr 3954 32 fertility fertility NN cord-028721-x6f26ahr 3954 33 A a DT cord-028721-x6f26ahr 3954 34 novel novel JJ cord-028721-x6f26ahr 3954 35 circulating circulate VBG cord-028721-x6f26ahr 3954 36 hormone hormone NN cord-028721-x6f26ahr 3954 37 of of IN cord-028721-x6f26ahr 3954 38 testis testis NN cord-028721-x6f26ahr 3954 39 origin origin NN cord-028721-x6f26ahr 3954 40 in in IN cord-028721-x6f26ahr 3955 1 humans human NNS cord-028721-x6f26ahr 3955 2 Calretinin Calretinin NNP cord-028721-x6f26ahr 3955 3 is be VBZ cord-028721-x6f26ahr 3955 4 expressed express VBN cord-028721-x6f26ahr 3955 5 in in IN cord-028721-x6f26ahr 3955 6 the the DT cord-028721-x6f26ahr 3955 7 Leydig Leydig NNP cord-028721-x6f26ahr 3955 8 cells cell NNS cord-028721-x6f26ahr 3955 9 of of IN cord-028721-x6f26ahr 3955 10 rat rat NN cord-028721-x6f26ahr 3955 11 testis testis NN cord-028721-x6f26ahr 3955 12 Calretinin Calretinin NNP cord-028721-x6f26ahr 3955 13 , , , cord-028721-x6f26ahr 3955 14 a a DT cord-028721-x6f26ahr 3955 15 more more RBR cord-028721-x6f26ahr 3955 16 sensitive sensitive JJ cord-028721-x6f26ahr 3955 17 but but CC cord-028721-x6f26ahr 3955 18 less less JJR cord-028721-x6f26ahr 3955 19 specifi specifi NN cord-028721-x6f26ahr 3955 20 c c NN cord-028721-x6f26ahr 3955 21 marker marker NN cord-028721-x6f26ahr 3955 22 than than IN cord-028721-x6f26ahr 3955 23 α α NN cord-028721-x6f26ahr 3955 24 - - HYPH cord-028721-x6f26ahr 3955 25 inhibin inhibin NNP cord-028721-x6f26ahr 3955 26 for for IN cord-028721-x6f26ahr 3955 27 ovarian ovarian JJ cord-028721-x6f26ahr 3955 28 sex sex NN cord-028721-x6f26ahr 3955 29 cord cord NN cord-028721-x6f26ahr 3955 30 - - HYPH cord-028721-x6f26ahr 3955 31 stromal stromal JJ cord-028721-x6f26ahr 3955 32 neoplasms neoplasm NNS cord-028721-x6f26ahr 3955 33 : : : cord-028721-x6f26ahr 3956 1 an an DT cord-028721-x6f26ahr 3956 2 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 3956 3 study study NN cord-028721-x6f26ahr 3956 4 of of IN cord-028721-x6f26ahr 3956 5 215 215 CD cord-028721-x6f26ahr 3956 6 cases case NNS cord-028721-x6f26ahr 3957 1 Barrier barrier NN cord-028721-x6f26ahr 3957 2 properties property NNS cord-028721-x6f26ahr 3957 3 of of IN cord-028721-x6f26ahr 3957 4 testis testis NN cord-028721-x6f26ahr 3957 5 microvessels microvessel VBZ cord-028721-x6f26ahr 3957 6 The the DT cord-028721-x6f26ahr 3957 7 Leydig Leydig NNP cord-028721-x6f26ahr 3957 8 cell cell NN cord-028721-x6f26ahr 3957 9 of of IN cord-028721-x6f26ahr 3957 10 the the DT cord-028721-x6f26ahr 3957 11 human human JJ cord-028721-x6f26ahr 3957 12 testis testis NN cord-028721-x6f26ahr 3957 13 -a -a HYPH cord-028721-x6f26ahr 3957 14 new new JJ cord-028721-x6f26ahr 3957 15 member member NN cord-028721-x6f26ahr 3957 16 of of IN cord-028721-x6f26ahr 3957 17 the the DT cord-028721-x6f26ahr 3957 18 diffuse diffuse JJ cord-028721-x6f26ahr 3957 19 neuroendocrine neuroendocrine JJ cord-028721-x6f26ahr 3957 20 system system NN cord-028721-x6f26ahr 3957 21 Sertoli Sertoli NNP cord-028721-x6f26ahr 3957 22 and and CC cord-028721-x6f26ahr 3957 23 Leydig Leydig NNP cord-028721-x6f26ahr 3957 24 cells cell NNS cord-028721-x6f26ahr 3957 25 of of IN cord-028721-x6f26ahr 3957 26 the the DT cord-028721-x6f26ahr 3957 27 human human JJ cord-028721-x6f26ahr 3957 28 testis testis NN cord-028721-x6f26ahr 3958 1 express express VB cord-028721-x6f26ahr 3959 1 neurofi neurofi NNP cord-028721-x6f26ahr 3959 2 lament lament NNP cord-028721-x6f26ahr 3959 3 triplet triplet NN cord-028721-x6f26ahr 3959 4 proteins protein NNS cord-028721-x6f26ahr 3959 5 Isolation Isolation NNP cord-028721-x6f26ahr 3959 6 of of IN cord-028721-x6f26ahr 3959 7 human human JJ cord-028721-x6f26ahr 3959 8 Leydig leydig NN cord-028721-x6f26ahr 3959 9 cell cell NN cord-028721-x6f26ahr 3959 10 mesenchymal mesenchymal JJ cord-028721-x6f26ahr 3959 11 precursors precursor NNS cord-028721-x6f26ahr 3959 12 from from IN cord-028721-x6f26ahr 3959 13 patients patient NNS cord-028721-x6f26ahr 3959 14 with with IN cord-028721-x6f26ahr 3959 15 the the DT cord-028721-x6f26ahr 3959 16 androgen androgen NN cord-028721-x6f26ahr 3959 17 insensitivity insensitivity NN cord-028721-x6f26ahr 3959 18 syndrome syndrome NN cord-028721-x6f26ahr 3959 19 : : : cord-028721-x6f26ahr 3959 20 testosterone testosterone NN cord-028721-x6f26ahr 3959 21 production production NN cord-028721-x6f26ahr 3959 22 and and CC cord-028721-x6f26ahr 3959 23 response response NN cord-028721-x6f26ahr 3959 24 to to IN cord-028721-x6f26ahr 3959 25 human human JJ cord-028721-x6f26ahr 3959 26 chorionic chorionic JJ cord-028721-x6f26ahr 3959 27 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 3959 28 stimulation stimulation NN cord-028721-x6f26ahr 3959 29 in in IN cord-028721-x6f26ahr 3959 30 culture culture NN cord-028721-x6f26ahr 3959 31 Progenitor Progenitor NNP cord-028721-x6f26ahr 3959 32 cells cell NNS cord-028721-x6f26ahr 3959 33 of of IN cord-028721-x6f26ahr 3959 34 the the DT cord-028721-x6f26ahr 3959 35 testosterone testosterone NN cord-028721-x6f26ahr 3959 36 - - HYPH cord-028721-x6f26ahr 3959 37 producing produce VBG cord-028721-x6f26ahr 3959 38 Leydig Leydig NNP cord-028721-x6f26ahr 3959 39 cells cell NNS cord-028721-x6f26ahr 3959 40 revealed reveal VBD cord-028721-x6f26ahr 3959 41 Attrition Attrition NNP cord-028721-x6f26ahr 3959 42 of of IN cord-028721-x6f26ahr 3959 43 the the DT cord-028721-x6f26ahr 3959 44 human human JJ cord-028721-x6f26ahr 3959 45 Leydig Leydig NNP cord-028721-x6f26ahr 3959 46 cell cell NN cord-028721-x6f26ahr 3959 47 population population NN cord-028721-x6f26ahr 3959 48 with with IN cord-028721-x6f26ahr 3959 49 advancing advance VBG cord-028721-x6f26ahr 3959 50 age age NN cord-028721-x6f26ahr 3959 51 Effect effect NN cord-028721-x6f26ahr 3959 52 of of IN cord-028721-x6f26ahr 3959 53 ageing age VBG cord-028721-x6f26ahr 3959 54 on on IN cord-028721-x6f26ahr 3959 55 the the DT cord-028721-x6f26ahr 3959 56 volume volume NN cord-028721-x6f26ahr 3959 57 , , , cord-028721-x6f26ahr 3959 58 structure structure NN cord-028721-x6f26ahr 3959 59 and and CC cord-028721-x6f26ahr 3959 60 total total JJ cord-028721-x6f26ahr 3959 61 Leydig Leydig NNP cord-028721-x6f26ahr 3959 62 cell cell NN cord-028721-x6f26ahr 3959 63 content content NN cord-028721-x6f26ahr 3959 64 of of IN cord-028721-x6f26ahr 3959 65 human human JJ cord-028721-x6f26ahr 3959 66 testis testis NN cord-028721-x6f26ahr 3959 67 Stereological stereological JJ cord-028721-x6f26ahr 3959 68 analysis analysis NN cord-028721-x6f26ahr 3959 69 of of IN cord-028721-x6f26ahr 3959 70 Leydig Leydig NNP cord-028721-x6f26ahr 3959 71 cell cell NN cord-028721-x6f26ahr 3959 72 ultrastructure ultrastructure NN cord-028721-x6f26ahr 3959 73 in in IN cord-028721-x6f26ahr 3959 74 aged aged JJ cord-028721-x6f26ahr 3959 75 humans human NNS cord-028721-x6f26ahr 3959 76 Multinucleate Multinucleate NNP cord-028721-x6f26ahr 3959 77 Leydig Leydig NNP cord-028721-x6f26ahr 3959 78 cells cell NNS cord-028721-x6f26ahr 3959 79 in in IN cord-028721-x6f26ahr 3959 80 normal normal JJ cord-028721-x6f26ahr 3959 81 human human JJ cord-028721-x6f26ahr 3959 82 testes testis NNS cord-028721-x6f26ahr 3959 83 Mitosis mitosis NN cord-028721-x6f26ahr 3959 84 in in IN cord-028721-x6f26ahr 3959 85 adult adult NN cord-028721-x6f26ahr 3959 86 human human JJ cord-028721-x6f26ahr 3959 87 Leydig Leydig NNP cord-028721-x6f26ahr 3959 88 cells cell NNS cord-028721-x6f26ahr 3959 89 Leydig leydig NN cord-028721-x6f26ahr 3959 90 cell cell NN cord-028721-x6f26ahr 3959 91 numbers number NNS cord-028721-x6f26ahr 3959 92 , , , cord-028721-x6f26ahr 3959 93 daily daily JJ cord-028721-x6f26ahr 3959 94 sperm sperm NN cord-028721-x6f26ahr 3959 95 production production NN cord-028721-x6f26ahr 3959 96 and and CC cord-028721-x6f26ahr 3959 97 serum serum NN cord-028721-x6f26ahr 3959 98 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 3959 99 levels level NNS cord-028721-x6f26ahr 3959 100 in in IN cord-028721-x6f26ahr 3959 101 ageing age VBG cord-028721-x6f26ahr 3959 102 men man NNS cord-028721-x6f26ahr 3959 103 Agerelated agerelated JJ cord-028721-x6f26ahr 3959 104 change change NN cord-028721-x6f26ahr 3959 105 in in IN cord-028721-x6f26ahr 3959 106 numbers number NNS cord-028721-x6f26ahr 3959 107 of of IN cord-028721-x6f26ahr 3959 108 other other JJ cord-028721-x6f26ahr 3959 109 interstitial interstitial JJ cord-028721-x6f26ahr 3959 110 cells cell NNS cord-028721-x6f26ahr 3959 111 in in IN cord-028721-x6f26ahr 3959 112 testes testis NNS cord-028721-x6f26ahr 3959 113 of of IN cord-028721-x6f26ahr 3959 114 adult adult NN cord-028721-x6f26ahr 3959 115 men man NNS cord-028721-x6f26ahr 3959 116 : : : cord-028721-x6f26ahr 3959 117 evidence evidence NN cord-028721-x6f26ahr 3959 118 bearing bear VBG cord-028721-x6f26ahr 3959 119 on on IN cord-028721-x6f26ahr 3959 120 the the DT cord-028721-x6f26ahr 3959 121 fate fate NN cord-028721-x6f26ahr 3959 122 of of IN cord-028721-x6f26ahr 3959 123 Leydig Leydig NNP cord-028721-x6f26ahr 3959 124 cells cell NNS cord-028721-x6f26ahr 3959 125 lost lose VBN cord-028721-x6f26ahr 3959 126 with with IN cord-028721-x6f26ahr 3959 127 increasing increase VBG cord-028721-x6f26ahr 3959 128 age age NN cord-028721-x6f26ahr 3959 129 Testosterone testosterone NN cord-028721-x6f26ahr 3959 130 and and CC cord-028721-x6f26ahr 3959 131 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3959 132 . . . cord-028721-x6f26ahr 3960 1 Identifi Identifi NNP cord-028721-x6f26ahr 3960 2 cation cation NN cord-028721-x6f26ahr 3960 3 of of IN cord-028721-x6f26ahr 3960 4 stage stage NN cord-028721-x6f26ahr 3960 5 - - HYPH cord-028721-x6f26ahr 3960 6 specifi specifi VBN cord-028721-x6f26ahr 3960 7 c c NN cord-028721-x6f26ahr 3960 8 , , , cord-028721-x6f26ahr 3960 9 androgen androgen NN cord-028721-x6f26ahr 3960 10 - - HYPH cord-028721-x6f26ahr 3960 11 regulated regulate VBN cord-028721-x6f26ahr 3960 12 proteins protein NNS cord-028721-x6f26ahr 3960 13 secreted secrete VBN cord-028721-x6f26ahr 3960 14 by by IN cord-028721-x6f26ahr 3960 15 adult adult NN cord-028721-x6f26ahr 3960 16 rat rat NN cord-028721-x6f26ahr 3960 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 3960 18 tubules tubule NNS cord-028721-x6f26ahr 3960 19 Regulation Regulation NNP cord-028721-x6f26ahr 3960 20 of of IN cord-028721-x6f26ahr 3960 21 the the DT cord-028721-x6f26ahr 3960 22 semininiferous semininiferous JJ cord-028721-x6f26ahr 3960 23 epithelium epithelium NN cord-028721-x6f26ahr 3960 24 Changes change NNS cord-028721-x6f26ahr 3960 25 in in IN cord-028721-x6f26ahr 3960 26 surface surface NN cord-028721-x6f26ahr 3960 27 area area NN cord-028721-x6f26ahr 3960 28 and and CC cord-028721-x6f26ahr 3960 29 number number NN cord-028721-x6f26ahr 3960 30 of of IN cord-028721-x6f26ahr 3960 31 Leydig Leydig NNP cord-028721-x6f26ahr 3960 32 cells cell NNS cord-028721-x6f26ahr 3960 33 in in IN cord-028721-x6f26ahr 3960 34 relation relation NN cord-028721-x6f26ahr 3960 35 to to IN cord-028721-x6f26ahr 3960 36 the the DT cord-028721-x6f26ahr 3960 37 6 6 CD cord-028721-x6f26ahr 3960 38 stages stage NNS cord-028721-x6f26ahr 3960 39 of of IN cord-028721-x6f26ahr 3960 40 the the DT cord-028721-x6f26ahr 3960 41 cycle cycle NN cord-028721-x6f26ahr 3960 42 of of IN cord-028721-x6f26ahr 3960 43 the the DT cord-028721-x6f26ahr 3960 44 human human JJ cord-028721-x6f26ahr 3960 45 seminiferous seminiferous JJ cord-028721-x6f26ahr 3960 46 epithelium epithelium NN cord-028721-x6f26ahr 3960 47 Actions action NNS cord-028721-x6f26ahr 3960 48 of of IN cord-028721-x6f26ahr 3960 49 the the DT cord-028721-x6f26ahr 3960 50 testicular testicular JJ cord-028721-x6f26ahr 3960 51 paracrine paracrine JJ cord-028721-x6f26ahr 3960 52 factor factor NN cord-028721-x6f26ahr 3960 53 ( ( -LRB- cord-028721-x6f26ahr 3960 54 P p NN cord-028721-x6f26ahr 3960 55 - - HYPH cord-028721-x6f26ahr 3960 56 Mod Mod NNP cord-028721-x6f26ahr 3960 57 - - HYPH cord-028721-x6f26ahr 3960 58 S S NNP cord-028721-x6f26ahr 3960 59 ) ) -RRB- cord-028721-x6f26ahr 3960 60 on on IN cord-028721-x6f26ahr 3960 61 Sertoli sertoli JJ cord-028721-x6f26ahr 3960 62 cell cell NN cord-028721-x6f26ahr 3960 63 transferrin transferrin NN cord-028721-x6f26ahr 3960 64 secretion secretion NN cord-028721-x6f26ahr 3960 65 througout througout IN cord-028721-x6f26ahr 3960 66 pubertal pubertal JJ cord-028721-x6f26ahr 3960 67 development development NN cord-028721-x6f26ahr 3960 68 Diaphragmatic diaphragmatic JJ cord-028721-x6f26ahr 3960 69 hernia hernia NN cord-028721-x6f26ahr 3960 70 in in IN cord-028721-x6f26ahr 3960 71 Denys Denys NNP cord-028721-x6f26ahr 3960 72 - - HYPH cord-028721-x6f26ahr 3960 73 Drash Drash NNP cord-028721-x6f26ahr 3960 74 syndrome syndrome NN cord-028721-x6f26ahr 3961 1 Sex sex NN cord-028721-x6f26ahr 3961 2 reversal reversal NN cord-028721-x6f26ahr 3961 3 and and CC cord-028721-x6f26ahr 3961 4 diaphragmatic diaphragmatic JJ cord-028721-x6f26ahr 3961 5 hernia hernia NN cord-028721-x6f26ahr 3961 6 in in IN cord-028721-x6f26ahr 3961 7 phenotypically phenotypically RB cord-028721-x6f26ahr 3961 8 female female JJ cord-028721-x6f26ahr 3961 9 sibs sib NNS cord-028721-x6f26ahr 3961 10 with with IN cord-028721-x6f26ahr 3961 11 normal normal JJ cord-028721-x6f26ahr 3961 12 XY XY NNP cord-028721-x6f26ahr 3961 13 chromosomes chromosome NNS cord-028721-x6f26ahr 3961 14 Clinical clinical JJ cord-028721-x6f26ahr 3961 15 expression expression NN cord-028721-x6f26ahr 3961 16 and and CC cord-028721-x6f26ahr 3961 17 SRY SRY NNP cord-028721-x6f26ahr 3961 18 gene gene NN cord-028721-x6f26ahr 3961 19 analysis analysis NN cord-028721-x6f26ahr 3961 20 in in IN cord-028721-x6f26ahr 3961 21 XY XY NNP cord-028721-x6f26ahr 3961 22 subjets subjet NNS cord-028721-x6f26ahr 3961 23 lacking lack VBG cord-028721-x6f26ahr 3961 24 gonadal gonadal JJ cord-028721-x6f26ahr 3961 25 tissue tissue NN cord-028721-x6f26ahr 3961 26 PAGOD PAGOD NNP cord-028721-x6f26ahr 3961 27 syndrome syndrome NN cord-028721-x6f26ahr 3961 28 : : : cord-028721-x6f26ahr 3961 29 eighth eighth JJ cord-028721-x6f26ahr 3961 30 case case NN cord-028721-x6f26ahr 3961 31 and and CC cord-028721-x6f26ahr 3961 32 comparison comparison NN cord-028721-x6f26ahr 3961 33 to to IN cord-028721-x6f26ahr 3961 34 animal animal NN cord-028721-x6f26ahr 3961 35 models model NNS cord-028721-x6f26ahr 3961 36 of of IN cord-028721-x6f26ahr 3961 37 congenital congenital JJ cord-028721-x6f26ahr 3961 38 vitamin vitamin NN cord-028721-x6f26ahr 3961 39 A a DT cord-028721-x6f26ahr 3961 40 defi defi FW cord-028721-x6f26ahr 3961 41 ciency ciency NN cord-028721-x6f26ahr 3961 42 Familial familial JJ cord-028721-x6f26ahr 3961 43 occurrence occurrence NN cord-028721-x6f26ahr 3961 44 of of IN cord-028721-x6f26ahr 3961 45 agonadism agonadism NN cord-028721-x6f26ahr 3961 46 and and CC cord-028721-x6f26ahr 3961 47 multiple multiple JJ cord-028721-x6f26ahr 3961 48 internal internal JJ cord-028721-x6f26ahr 3961 49 malformations malformation NNS cord-028721-x6f26ahr 3961 50 in in IN cord-028721-x6f26ahr 3961 51 phenotypically phenotypically RB cord-028721-x6f26ahr 3961 52 normal normal JJ cord-028721-x6f26ahr 3961 53 girls girl NNS cord-028721-x6f26ahr 3961 54 with with IN cord-028721-x6f26ahr 3961 55 46,XY 46,xy CD cord-028721-x6f26ahr 3961 56 and and CC cord-028721-x6f26ahr 3961 57 46,XX 46,xx CD cord-028721-x6f26ahr 3961 58 karyotypes karyotype NNS cord-028721-x6f26ahr 3961 59 , , , cord-028721-x6f26ahr 3961 60 respectively respectively RB cord-028721-x6f26ahr 3961 61 : : : cord-028721-x6f26ahr 3961 62 a a DT cord-028721-x6f26ahr 3961 63 new new JJ cord-028721-x6f26ahr 3961 64 autosomal autosomal JJ cord-028721-x6f26ahr 3961 65 recessive recessive JJ cord-028721-x6f26ahr 3961 66 syndrome syndrome NN cord-028721-x6f26ahr 3961 67 Low low JJ cord-028721-x6f26ahr 3961 68 birth birth NN cord-028721-x6f26ahr 3961 69 - - HYPH cord-028721-x6f26ahr 3961 70 weight weight NN cord-028721-x6f26ahr 3961 71 , , , cord-028721-x6f26ahr 3961 72 microcephalic microcephalic JJ cord-028721-x6f26ahr 3961 73 malformation malformation NN cord-028721-x6f26ahr 3961 74 syndrome syndrome NN cord-028721-x6f26ahr 3961 75 in in IN cord-028721-x6f26ahr 3961 76 a a DT cord-028721-x6f26ahr 3961 77 46,XX 46,xx CD cord-028721-x6f26ahr 3961 78 girl girl NN cord-028721-x6f26ahr 3961 79 and and CC cord-028721-x6f26ahr 3961 80 her -PRON- PRP$ cord-028721-x6f26ahr 3961 81 46,XY 46,xy CD cord-028721-x6f26ahr 3961 82 sister sister NN cord-028721-x6f26ahr 3961 83 with with IN cord-028721-x6f26ahr 3961 84 agonadism agonadism NN cord-028721-x6f26ahr 3961 85 : : : cord-028721-x6f26ahr 3961 86 third third JJ cord-028721-x6f26ahr 3961 87 report report NN cord-028721-x6f26ahr 3961 88 of of IN cord-028721-x6f26ahr 3961 89 the the DT cord-028721-x6f26ahr 3961 90 Kennerknecht Kennerknecht NNP cord-028721-x6f26ahr 3961 91 syndrome syndrome NN cord-028721-x6f26ahr 3961 92 or or CC cord-028721-x6f26ahr 3961 93 autosomal autosomal JJ cord-028721-x6f26ahr 3961 94 recessive recessive JJ cord-028721-x6f26ahr 3961 95 Seckel Seckel NNP cord-028721-x6f26ahr 3961 96 - - HYPH cord-028721-x6f26ahr 3961 97 like like JJ cord-028721-x6f26ahr 3961 98 syndrome syndrome NN cord-028721-x6f26ahr 3961 99 with with IN cord-028721-x6f26ahr 3961 100 previously previously RB cord-028721-x6f26ahr 3961 101 undescribed undescribed JJ cord-028721-x6f26ahr 3961 102 genital genital JJ cord-028721-x6f26ahr 3961 103 anomalies anomaly NNS cord-028721-x6f26ahr 3961 104 Agonadism Agonadism NNP cord-028721-x6f26ahr 3961 105 in in IN cord-028721-x6f26ahr 3961 106 a a DT cord-028721-x6f26ahr 3961 107 46,XY 46,xy CD cord-028721-x6f26ahr 3961 108 patient patient NN cord-028721-x6f26ahr 3961 109 with with IN cord-028721-x6f26ahr 3961 110 CHARGE CHARGE NNP cord-028721-x6f26ahr 3961 111 association association NNP cord-028721-x6f26ahr 3962 1 The the DT cord-028721-x6f26ahr 3962 2 syndrome syndrome NN cord-028721-x6f26ahr 3962 3 of of IN cord-028721-x6f26ahr 3962 4 rudimentary rudimentary JJ cord-028721-x6f26ahr 3962 5 testes testis NNS cord-028721-x6f26ahr 3962 6 : : : cord-028721-x6f26ahr 3962 7 occurrence occurrence NN cord-028721-x6f26ahr 3962 8 in in IN cord-028721-x6f26ahr 3962 9 live live JJ cord-028721-x6f26ahr 3962 10 siblings sibling NNS cord-028721-x6f26ahr 3963 1 Identical identical JJ cord-028721-x6f26ahr 3963 2 twins twin NNS cord-028721-x6f26ahr 3963 3 discordant discordant JJ cord-028721-x6f26ahr 3963 4 for for IN cord-028721-x6f26ahr 3964 1 the the DT cord-028721-x6f26ahr 3964 2 ' ' `` cord-028721-x6f26ahr 3964 3 rudimentary rudimentary JJ cord-028721-x6f26ahr 3964 4 testes testis NNS cord-028721-x6f26ahr 3964 5 ' ' POS cord-028721-x6f26ahr 3964 6 syndrome syndrome NN cord-028721-x6f26ahr 3964 7 Rudimentary rudimentary JJ cord-028721-x6f26ahr 3964 8 testes testis NNS cord-028721-x6f26ahr 3964 9 syndrome syndrome NN cord-028721-x6f26ahr 3964 10 revisited revisit VBD cord-028721-x6f26ahr 3964 11 Congenital Congenital NNP cord-028721-x6f26ahr 3964 12 anorchism anorchism NN cord-028721-x6f26ahr 3964 13 : : : cord-028721-x6f26ahr 3964 14 diagnostic diagnostic JJ cord-028721-x6f26ahr 3964 15 and and CC cord-028721-x6f26ahr 3964 16 therapeutic therapeutic JJ cord-028721-x6f26ahr 3964 17 aspects aspect NNS cord-028721-x6f26ahr 3964 18 Congenital congenital JJ cord-028721-x6f26ahr 3964 19 bilateral bilateral JJ cord-028721-x6f26ahr 3964 20 anorchia anorchia NN cord-028721-x6f26ahr 3964 21 : : : cord-028721-x6f26ahr 3964 22 clinical clinical JJ cord-028721-x6f26ahr 3964 23 , , , cord-028721-x6f26ahr 3964 24 hormonal hormonal JJ cord-028721-x6f26ahr 3964 25 and and CC cord-028721-x6f26ahr 3964 26 imaging imaging NN cord-028721-x6f26ahr 3964 27 study study NN cord-028721-x6f26ahr 3964 28 in in IN cord-028721-x6f26ahr 3964 29 12 12 CD cord-028721-x6f26ahr 3964 30 cases case NNS cord-028721-x6f26ahr 3964 31 PCR PCR NNP cord-028721-x6f26ahr 3964 32 analysis analysis NN cord-028721-x6f26ahr 3964 33 and and CC cord-028721-x6f26ahr 3964 34 sequencing sequencing NN cord-028721-x6f26ahr 3964 35 of of IN cord-028721-x6f26ahr 3964 36 the the DT cord-028721-x6f26ahr 3964 37 SRY SRY NNP cord-028721-x6f26ahr 3964 38 sex sex NN cord-028721-x6f26ahr 3964 39 determining determine VBG cord-028721-x6f26ahr 3964 40 gene gene NN cord-028721-x6f26ahr 3964 41 in in IN cord-028721-x6f26ahr 3964 42 four four CD cord-028721-x6f26ahr 3964 43 patients patient NNS cord-028721-x6f26ahr 3964 44 with with IN cord-028721-x6f26ahr 3964 45 bilateral bilateral JJ cord-028721-x6f26ahr 3964 46 congenital congenital JJ cord-028721-x6f26ahr 3964 47 anorchia anorchia . cord-028721-x6f26ahr 3965 1 Is be VBZ cord-028721-x6f26ahr 3965 2 bilateral bilateral JJ cord-028721-x6f26ahr 3965 3 congenital congenital JJ cord-028721-x6f26ahr 3965 4 anorchia anorchia NN cord-028721-x6f26ahr 3965 5 genetically genetically RB cord-028721-x6f26ahr 3965 6 determined determine VBN cord-028721-x6f26ahr 3965 7 ? ? . cord-028721-x6f26ahr 3966 1 The the DT cord-028721-x6f26ahr 3966 2 vanishing vanish VBG cord-028721-x6f26ahr 3966 3 testis testis NN cord-028721-x6f26ahr 3966 4 syndrome syndrome NN cord-028721-x6f26ahr 3966 5 . . . cord-028721-x6f26ahr 3967 1 Indications indication NNS cord-028721-x6f26ahr 3967 2 for for IN cord-028721-x6f26ahr 3967 3 conservative conservative JJ cord-028721-x6f26ahr 3967 4 therapy therapy NN cord-028721-x6f26ahr 3968 1 The the DT cord-028721-x6f26ahr 3968 2 vanishing vanish VBG cord-028721-x6f26ahr 3968 3 testis testis NN cord-028721-x6f26ahr 3969 1 The the DT cord-028721-x6f26ahr 3969 2 vanishing vanish VBG cord-028721-x6f26ahr 3969 3 testis testis NN cord-028721-x6f26ahr 3969 4 Is be VBZ cord-028721-x6f26ahr 3969 5 the the DT cord-028721-x6f26ahr 3969 6 vanished vanish VBN cord-028721-x6f26ahr 3969 7 testis testis NN cord-028721-x6f26ahr 3969 8 always always RB cord-028721-x6f26ahr 3969 9 a a DT cord-028721-x6f26ahr 3969 10 scrotal scrotal JJ cord-028721-x6f26ahr 3969 11 event event NN cord-028721-x6f26ahr 3969 12 ? ? . cord-028721-x6f26ahr 3970 1 Bilateral bilateral JJ cord-028721-x6f26ahr 3970 2 anorchia anorchia NN cord-028721-x6f26ahr 3970 3 : : : cord-028721-x6f26ahr 3970 4 discordance discordance NN cord-028721-x6f26ahr 3970 5 in in IN cord-028721-x6f26ahr 3970 6 monozygotic monozygotic JJ cord-028721-x6f26ahr 3970 7 twins twin NNS cord-028721-x6f26ahr 3971 1 An an DT cord-028721-x6f26ahr 3971 2 analysis analysis NN cord-028721-x6f26ahr 3971 3 of of IN cord-028721-x6f26ahr 3971 4 the the DT cord-028721-x6f26ahr 3971 5 genetic genetic JJ cord-028721-x6f26ahr 3971 6 factors factor NNS cord-028721-x6f26ahr 3971 7 involved involve VBN cord-028721-x6f26ahr 3971 8 in in IN cord-028721-x6f26ahr 3971 9 testicular testicular JJ cord-028721-x6f26ahr 3971 10 descent descent NN cord-028721-x6f26ahr 3971 11 in in IN cord-028721-x6f26ahr 3971 12 a a DT cord-028721-x6f26ahr 3971 13 cohort cohort NN cord-028721-x6f26ahr 3971 14 of of IN cord-028721-x6f26ahr 3971 15 14 14 CD cord-028721-x6f26ahr 3971 16 male male JJ cord-028721-x6f26ahr 3971 17 patients patient NNS cord-028721-x6f26ahr 3971 18 with with IN cord-028721-x6f26ahr 3971 19 anorchia anorchia NNP cord-028721-x6f26ahr 3971 20 Report Report NNP cord-028721-x6f26ahr 3971 21 of of IN cord-028721-x6f26ahr 3971 22 11 11 CD cord-028721-x6f26ahr 3971 23 cases case NNS cord-028721-x6f26ahr 3971 24 with with IN cord-028721-x6f26ahr 3971 25 discussion discussion NN cord-028721-x6f26ahr 3971 26 of of IN cord-028721-x6f26ahr 3971 27 etiology etiology NN cord-028721-x6f26ahr 3971 28 and and CC cord-028721-x6f26ahr 3971 29 pathogenesis pathogenesis NN cord-028721-x6f26ahr 3971 30 Hyperplasia hyperplasia NN cord-028721-x6f26ahr 3971 31 of of IN cord-028721-x6f26ahr 3971 32 spermatic spermatic JJ cord-028721-x6f26ahr 3971 33 cord cord NN cord-028721-x6f26ahr 3971 34 nerves nerve NNS cord-028721-x6f26ahr 3971 35 : : : cord-028721-x6f26ahr 3971 36 a a DT cord-028721-x6f26ahr 3971 37 sign sign NN cord-028721-x6f26ahr 3971 38 of of IN cord-028721-x6f26ahr 3971 39 testicular testicular JJ cord-028721-x6f26ahr 3971 40 absence absence NN cord-028721-x6f26ahr 3971 41 Signifi Signifi NNP cord-028721-x6f26ahr 3971 42 cance cance NN cord-028721-x6f26ahr 3971 43 of of IN cord-028721-x6f26ahr 3971 44 testicular testicular JJ cord-028721-x6f26ahr 3971 45 biopsies biopsy NNS cord-028721-x6f26ahr 3971 46 in in IN cord-028721-x6f26ahr 3971 47 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3971 48 in in IN cord-028721-x6f26ahr 3971 49 children child NNS cord-028721-x6f26ahr 3971 50 Human human JJ cord-028721-x6f26ahr 3971 51 monorchism monorchism NN cord-028721-x6f26ahr 3971 52 : : : cord-028721-x6f26ahr 3971 53 A a DT cord-028721-x6f26ahr 3971 54 clinicopathological clinicopathological JJ cord-028721-x6f26ahr 3971 55 study study NN cord-028721-x6f26ahr 3971 56 of of IN cord-028721-x6f26ahr 3971 57 unilateral unilateral JJ cord-028721-x6f26ahr 3971 58 absent absent JJ cord-028721-x6f26ahr 3971 59 testes testis NNS cord-028721-x6f26ahr 3971 60 in in IN cord-028721-x6f26ahr 3971 61 65 65 CD cord-028721-x6f26ahr 3971 62 boys boy NNS cord-028721-x6f26ahr 3971 63 Testicular Testicular NNP cord-028721-x6f26ahr 3971 64 regression regression NN cord-028721-x6f26ahr 3971 65 syndrome syndrome NN cord-028721-x6f26ahr 3971 66 a a DT cord-028721-x6f26ahr 3971 67 pathological pathological JJ cord-028721-x6f26ahr 3971 68 study study NN cord-028721-x6f26ahr 3971 69 of of IN cord-028721-x6f26ahr 3971 70 77 77 CD cord-028721-x6f26ahr 3971 71 cases case NNS cord-028721-x6f26ahr 3971 72 Testicular testicular JJ cord-028721-x6f26ahr 3971 73 regression regression NN cord-028721-x6f26ahr 3971 74 syndrome syndrome NN cord-028721-x6f26ahr 3971 75 : : : cord-028721-x6f26ahr 3971 76 a a DT cord-028721-x6f26ahr 3971 77 clinical clinical JJ cord-028721-x6f26ahr 3971 78 and and CC cord-028721-x6f26ahr 3971 79 pathologic pathologic JJ cord-028721-x6f26ahr 3971 80 study study NN cord-028721-x6f26ahr 3971 81 of of IN cord-028721-x6f26ahr 3971 82 11 11 CD cord-028721-x6f26ahr 3971 83 cases case NNS cord-028721-x6f26ahr 3971 84 Laparoscopic laparoscopic JJ cord-028721-x6f26ahr 3971 85 and and CC cord-028721-x6f26ahr 3971 86 histologic histologic JJ cord-028721-x6f26ahr 3971 87 evaluation evaluation NN cord-028721-x6f26ahr 3971 88 of of IN cord-028721-x6f26ahr 3971 89 the the DT cord-028721-x6f26ahr 3971 90 inguinal inguinal JJ cord-028721-x6f26ahr 3971 91 vanishing vanish VBG cord-028721-x6f26ahr 3971 92 testis testis NN cord-028721-x6f26ahr 3971 93 Histological histological JJ cord-028721-x6f26ahr 3971 94 evaluation evaluation NN cord-028721-x6f26ahr 3971 95 of of IN cord-028721-x6f26ahr 3971 96 the the DT cord-028721-x6f26ahr 3971 97 testicular testicular JJ cord-028721-x6f26ahr 3971 98 nubbin nubbin NN cord-028721-x6f26ahr 3971 99 in in IN cord-028721-x6f26ahr 3971 100 the the DT cord-028721-x6f26ahr 3971 101 vanishing vanish VBG cord-028721-x6f26ahr 3971 102 testis testis NN cord-028721-x6f26ahr 3971 103 syndrome syndrome NN cord-028721-x6f26ahr 3971 104 Ureteral Ureteral NNP cord-028721-x6f26ahr 3971 105 ectopia ectopia NN cord-028721-x6f26ahr 3971 106 into into IN cord-028721-x6f26ahr 3971 107 cystic cystic JJ cord-028721-x6f26ahr 3971 108 seminal seminal JJ cord-028721-x6f26ahr 3971 109 vesicle vesicle NN cord-028721-x6f26ahr 3971 110 with with IN cord-028721-x6f26ahr 3971 111 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 3971 112 renal renal JJ cord-028721-x6f26ahr 3971 113 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 3971 114 and and CC cord-028721-x6f26ahr 3971 115 monorchia monorchia NNP cord-028721-x6f26ahr 3971 116 Renal Renal NNP cord-028721-x6f26ahr 3971 117 and and CC cord-028721-x6f26ahr 3971 118 testicular testicular JJ cord-028721-x6f26ahr 3971 119 agenesis agenesis NN cord-028721-x6f26ahr 3971 120 in in IN cord-028721-x6f26ahr 3971 121 a a DT cord-028721-x6f26ahr 3971 122 patient patient NN cord-028721-x6f26ahr 3971 123 with with IN cord-028721-x6f26ahr 3971 124 Darier Darier NNP cord-028721-x6f26ahr 3971 125 's 's POS cord-028721-x6f26ahr 3971 126 disease disease NN cord-028721-x6f26ahr 3971 127 Findings finding NNS cord-028721-x6f26ahr 3971 128 : : : cord-028721-x6f26ahr 3972 1 small small JJ cord-028721-x6f26ahr 3972 2 testicles testicle NNS cord-028721-x6f26ahr 3972 3 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 3972 4 's 's POS cord-028721-x6f26ahr 3972 5 syndrome syndrome NN cord-028721-x6f26ahr 3972 6 diagnosed diagnose VBD cord-028721-x6f26ahr 3972 7 three three CD cord-028721-x6f26ahr 3972 8 years year NNS cord-028721-x6f26ahr 3972 9 after after IN cord-028721-x6f26ahr 3972 10 surgery surgery NN cord-028721-x6f26ahr 3972 11 for for IN cord-028721-x6f26ahr 3972 12 mediastinal mediastinal JJ cord-028721-x6f26ahr 3972 13 teratoma teratoma NN cord-028721-x6f26ahr 3972 14 Kenny Kenny NNP cord-028721-x6f26ahr 3972 15 - - HYPH cord-028721-x6f26ahr 3972 16 Caffey Caffey NNP cord-028721-x6f26ahr 3972 17 syndrome syndrome NN cord-028721-x6f26ahr 3972 18 and and CC cord-028721-x6f26ahr 3972 19 microorchidism microorchidism NN cord-028721-x6f26ahr 3972 20 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3972 21 : : : cord-028721-x6f26ahr 3972 22 case case NN cord-028721-x6f26ahr 3972 23 report report NN cord-028721-x6f26ahr 3972 24 and and CC cord-028721-x6f26ahr 3972 25 review review NN cord-028721-x6f26ahr 3972 26 of of IN cord-028721-x6f26ahr 3972 27 literature literature NN cord-028721-x6f26ahr 3972 28 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3972 29 : : : cord-028721-x6f26ahr 3972 30 sonographic sonographic NNP cord-028721-x6f26ahr 3972 31 and and CC cord-028721-x6f26ahr 3972 32 magnetic magnetic JJ cord-028721-x6f26ahr 3972 33 resonance resonance NN cord-028721-x6f26ahr 3972 34 image image NN cord-028721-x6f26ahr 3972 35 fi fi NN cord-028721-x6f26ahr 3972 36 ndings nding NNS cord-028721-x6f26ahr 3973 1 A a DT cord-028721-x6f26ahr 3973 2 case case NN cord-028721-x6f26ahr 3973 3 of of IN cord-028721-x6f26ahr 3973 4 supernumerary supernumerary JJ cord-028721-x6f26ahr 3973 5 testis testis NN cord-028721-x6f26ahr 3973 6 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3973 7 presenting present VBG cord-028721-x6f26ahr 3973 8 as as IN cord-028721-x6f26ahr 3973 9 retractile retractile JJ cord-028721-x6f26ahr 3973 10 testes testis NNS cord-028721-x6f26ahr 3974 1 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3974 2 : : : cord-028721-x6f26ahr 3974 3 evaluation evaluation NN cord-028721-x6f26ahr 3974 4 by by IN cord-028721-x6f26ahr 3974 5 MR MR NNP cord-028721-x6f26ahr 3974 6 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3974 7 : : : cord-028721-x6f26ahr 3974 8 An an DT cord-028721-x6f26ahr 3974 9 unusual unusual JJ cord-028721-x6f26ahr 3974 10 case case NN cord-028721-x6f26ahr 3974 11 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3974 12 : : : cord-028721-x6f26ahr 3974 13 a a DT cord-028721-x6f26ahr 3974 14 strange strange JJ cord-028721-x6f26ahr 3974 15 anomaly anomaly NN cord-028721-x6f26ahr 3974 16 with with IN cord-028721-x6f26ahr 3974 17 unsuspected unsuspected JJ cord-028721-x6f26ahr 3974 18 properties property NNS cord-028721-x6f26ahr 3974 19 Bilateral bilateral JJ cord-028721-x6f26ahr 3975 1 double double JJ cord-028721-x6f26ahr 3975 2 by by IN cord-028721-x6f26ahr 3975 3 testis testis NN cord-028721-x6f26ahr 3975 4 : : : cord-028721-x6f26ahr 3975 5 evaluation evaluation NN cord-028721-x6f26ahr 3975 6 magnetic magnetic JJ cord-028721-x6f26ahr 3975 7 resonance resonance NN cord-028721-x6f26ahr 3975 8 imaging image VBG cord-028721-x6f26ahr 3975 9 One one CD cord-028721-x6f26ahr 3975 10 man man NN cord-028721-x6f26ahr 3975 11 with with IN cord-028721-x6f26ahr 3975 12 fi fi NNP cord-028721-x6f26ahr 3975 13 ve ve NNP cord-028721-x6f26ahr 3975 14 testes testis NNS cord-028721-x6f26ahr 3975 15 : : : cord-028721-x6f26ahr 3975 16 report report NN cord-028721-x6f26ahr 3975 17 of of IN cord-028721-x6f26ahr 3975 18 case case NN cord-028721-x6f26ahr 3975 19 Triorchidism Triorchidism NNP cord-028721-x6f26ahr 3975 20 with with IN cord-028721-x6f26ahr 3975 21 normal normal JJ cord-028721-x6f26ahr 3975 22 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3975 23 : : : cord-028721-x6f26ahr 3975 24 an an DT cord-028721-x6f26ahr 3975 25 unusual unusual JJ cord-028721-x6f26ahr 3975 26 cause cause NN cord-028721-x6f26ahr 3975 27 for for IN cord-028721-x6f26ahr 3975 28 failure failure NN cord-028721-x6f26ahr 3975 29 of of IN cord-028721-x6f26ahr 3975 30 vasectomy vasectomy NN cord-028721-x6f26ahr 3975 31 Abdominal abdominal JJ cord-028721-x6f26ahr 3975 32 polyorchidism polyorchidism NN cord-028721-x6f26ahr 3975 33 : : : cord-028721-x6f26ahr 3975 34 a a DT cord-028721-x6f26ahr 3975 35 case case NN cord-028721-x6f26ahr 3975 36 report report NN cord-028721-x6f26ahr 3975 37 and and CC cord-028721-x6f26ahr 3975 38 review review NN cord-028721-x6f26ahr 3975 39 of of IN cord-028721-x6f26ahr 3975 40 the the DT cord-028721-x6f26ahr 3975 41 literature literature NN cord-028721-x6f26ahr 3975 42 Ultrasound Ultrasound NNP cord-028721-x6f26ahr 3975 43 of of IN cord-028721-x6f26ahr 3975 44 polyorchidism polyorchidism NN cord-028721-x6f26ahr 3975 45 : : : cord-028721-x6f26ahr 3976 1 Case case NN cord-028721-x6f26ahr 3976 2 report report NN cord-028721-x6f26ahr 3976 3 and and CC cord-028721-x6f26ahr 3976 4 literature literature NN cord-028721-x6f26ahr 3976 5 review review NN cord-028721-x6f26ahr 3977 1 Sonographic sonographic JJ cord-028721-x6f26ahr 3977 2 features feature NNS cord-028721-x6f26ahr 3977 3 of of IN cord-028721-x6f26ahr 3977 4 polyorchidism polyorchidism NN cord-028721-x6f26ahr 3977 5 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3977 6 : : : cord-028721-x6f26ahr 3978 1 Case case NN cord-028721-x6f26ahr 3978 2 report report NN cord-028721-x6f26ahr 3978 3 and and CC cord-028721-x6f26ahr 3978 4 literature literature NN cord-028721-x6f26ahr 3978 5 review review NN cord-028721-x6f26ahr 3979 1 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3979 2 discovered discover VBD cord-028721-x6f26ahr 3979 3 as as IN cord-028721-x6f26ahr 3979 4 testicular testicular JJ cord-028721-x6f26ahr 3979 5 torsion torsion NN cord-028721-x6f26ahr 3979 6 associated associate VBN cord-028721-x6f26ahr 3979 7 with with IN cord-028721-x6f26ahr 3979 8 undescended undescended JJ cord-028721-x6f26ahr 3979 9 atrophic atrophic JJ cord-028721-x6f26ahr 3979 10 contralateral contralateral JJ cord-028721-x6f26ahr 3979 11 testis testis NN cord-028721-x6f26ahr 3979 12 . . . cord-028721-x6f26ahr 3980 1 A a DT cord-028721-x6f26ahr 3980 2 surgical surgical JJ cord-028721-x6f26ahr 3980 3 solution solution NN cord-028721-x6f26ahr 3981 1 Revisión Revisión NNP cord-028721-x6f26ahr 3981 2 y y NNP cord-028721-x6f26ahr 3981 3 aportación aportación NNP cord-028721-x6f26ahr 3981 4 de de NNP cord-028721-x6f26ahr 3981 5 un un NNP cord-028721-x6f26ahr 3981 6 nuevo nuevo NNP cord-028721-x6f26ahr 3981 7 caso caso NNP cord-028721-x6f26ahr 3981 8 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3981 9 discovered discover VBD cord-028721-x6f26ahr 3981 10 as as IN cord-028721-x6f26ahr 3981 11 testicular testicular JJ cord-028721-x6f26ahr 3981 12 torsion torsion NN cord-028721-x6f26ahr 3982 1 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3982 2 with with IN cord-028721-x6f26ahr 3982 3 normal normal JJ cord-028721-x6f26ahr 3982 4 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3982 5 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3982 6 with with IN cord-028721-x6f26ahr 3982 7 normal normal JJ cord-028721-x6f26ahr 3982 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3982 9 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3982 10 with with IN cord-028721-x6f26ahr 3982 11 normal normal JJ cord-028721-x6f26ahr 3982 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 3982 13 and and CC cord-028721-x6f26ahr 3982 14 equal equal JJ cord-028721-x6f26ahr 3982 15 sized sized JJ cord-028721-x6f26ahr 3982 16 testes testis NNS cord-028721-x6f26ahr 3982 17 . . . cord-028721-x6f26ahr 3983 1 A a DT cord-028721-x6f26ahr 3983 2 theory theory NN cord-028721-x6f26ahr 3983 3 of of IN cord-028721-x6f26ahr 3983 4 embryonal embryonal JJ cord-028721-x6f26ahr 3983 5 development development NN cord-028721-x6f26ahr 3983 6 Testiculo Testiculo NNP cord-028721-x6f26ahr 3983 7 supernumerario supernumerario NN cord-028721-x6f26ahr 3983 8 . . . cord-028721-x6f26ahr 3984 1 Comunicación Comunicación NNP cord-028721-x6f26ahr 3984 2 de de IN cord-028721-x6f26ahr 3984 3 un un NNP cord-028721-x6f26ahr 3984 4 caso caso NNP cord-028721-x6f26ahr 3984 5 y y NNP cord-028721-x6f26ahr 3984 6 revisión revisión NNP cord-028721-x6f26ahr 3984 7 de de NNP cord-028721-x6f26ahr 3984 8 la la NNP cord-028721-x6f26ahr 3984 9 literatura literatura NNP cord-028721-x6f26ahr 3984 10 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3984 11 : : : cord-028721-x6f26ahr 3985 1 case case NNP cord-028721-x6f26ahr 3985 2 report report NN cord-028721-x6f26ahr 3985 3 and and CC cord-028721-x6f26ahr 3985 4 review review NN cord-028721-x6f26ahr 3985 5 of of IN cord-028721-x6f26ahr 3985 6 the the DT cord-028721-x6f26ahr 3985 7 literature literature NN cord-028721-x6f26ahr 3985 8 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3985 9 : : : cord-028721-x6f26ahr 3986 1 a a DT cord-028721-x6f26ahr 3986 2 case case NN cord-028721-x6f26ahr 3986 3 report report NN cord-028721-x6f26ahr 3986 4 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3986 5 : : : cord-028721-x6f26ahr 3986 6 report report NN cord-028721-x6f26ahr 3986 7 of of IN cord-028721-x6f26ahr 3986 8 a a DT cord-028721-x6f26ahr 3986 9 case case NN cord-028721-x6f26ahr 3986 10 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3986 11 in in IN cord-028721-x6f26ahr 3986 12 a a DT cord-028721-x6f26ahr 3986 13 newborn newborn NN cord-028721-x6f26ahr 3986 14 : : : cord-028721-x6f26ahr 3986 15 case case NN cord-028721-x6f26ahr 3986 16 report report NN cord-028721-x6f26ahr 3986 17 and and CC cord-028721-x6f26ahr 3986 18 review review NN cord-028721-x6f26ahr 3986 19 of of IN cord-028721-x6f26ahr 3986 20 the the DT cord-028721-x6f26ahr 3986 21 literature literature NN cord-028721-x6f26ahr 3986 22 Polyorchidism polyorchidism NN cord-028721-x6f26ahr 3986 23 : : : cord-028721-x6f26ahr 3986 24 A a DT cord-028721-x6f26ahr 3986 25 case case NN cord-028721-x6f26ahr 3986 26 report report NN cord-028721-x6f26ahr 3986 27 and and CC cord-028721-x6f26ahr 3986 28 review review NN cord-028721-x6f26ahr 3986 29 of of IN cord-028721-x6f26ahr 3986 30 the the DT cord-028721-x6f26ahr 3986 31 literature literature NN cord-028721-x6f26ahr 3986 32 Polyorchidism Polyorchidism NNP cord-028721-x6f26ahr 3986 33 and and CC cord-028721-x6f26ahr 3986 34 seminoma seminoma NN cord-028721-x6f26ahr 3986 35 in in IN cord-028721-x6f26ahr 3986 36 a a DT cord-028721-x6f26ahr 3986 37 child child NN cord-028721-x6f26ahr 3986 38 A a DT cord-028721-x6f26ahr 3986 39 case case NN cord-028721-x6f26ahr 3986 40 of of IN cord-028721-x6f26ahr 3986 41 polyorchidism polyorchidism NN cord-028721-x6f26ahr 3986 42 with with IN cord-028721-x6f26ahr 3986 43 testicular testicular JJ cord-028721-x6f26ahr 3986 44 teratoma teratoma NN cord-028721-x6f26ahr 3986 45 Signifi Signifi NNP cord-028721-x6f26ahr 3986 46 cance cance NN cord-028721-x6f26ahr 3986 47 of of IN cord-028721-x6f26ahr 3986 48 testicular testicular JJ cord-028721-x6f26ahr 3986 49 size size NN cord-028721-x6f26ahr 3986 50 measurement measurement NN cord-028721-x6f26ahr 3986 51 in in IN cord-028721-x6f26ahr 3986 52 andrology andrology NN cord-028721-x6f26ahr 3986 53 . . . cord-028721-x6f26ahr 3987 1 II II NNP cord-028721-x6f26ahr 3987 2 Correlation correlation NN cord-028721-x6f26ahr 3987 3 of of IN cord-028721-x6f26ahr 3987 4 testicular testicular JJ cord-028721-x6f26ahr 3987 5 size size NN cord-028721-x6f26ahr 3987 6 with with IN cord-028721-x6f26ahr 3987 7 testicular testicular JJ cord-028721-x6f26ahr 3987 8 function function NN cord-028721-x6f26ahr 3988 1 Congenital congenital JJ cord-028721-x6f26ahr 3988 2 Leydig Leydig NNP cord-028721-x6f26ahr 3988 3 cell cell NN cord-028721-x6f26ahr 3989 1 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3989 2 Evidence Evidence NNP cord-028721-x6f26ahr 3989 3 in in IN cord-028721-x6f26ahr 3989 4 favor favor NN cord-028721-x6f26ahr 3989 5 of of IN cord-028721-x6f26ahr 3989 6 the the DT cord-028721-x6f26ahr 3989 7 mechanical mechanical JJ cord-028721-x6f26ahr 3989 8 ( ( -LRB- cord-028721-x6f26ahr 3989 9 intrauterine intrauterine JJ cord-028721-x6f26ahr 3989 10 torsion torsion NN cord-028721-x6f26ahr 3989 11 ) ) -RRB- cord-028721-x6f26ahr 3989 12 theory theory NN cord-028721-x6f26ahr 3989 13 over over IN cord-028721-x6f26ahr 3989 14 the the DT cord-028721-x6f26ahr 3989 15 endocrinopathy endocrinopathy NN cord-028721-x6f26ahr 3989 16 ( ( -LRB- cord-028721-x6f26ahr 3989 17 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3989 18 ) ) -RRB- cord-028721-x6f26ahr 3989 19 theory theory NN cord-028721-x6f26ahr 3989 20 in in IN cord-028721-x6f26ahr 3989 21 the the DT cord-028721-x6f26ahr 3989 22 pathogenesis pathogenesis NN cord-028721-x6f26ahr 3989 23 of of IN cord-028721-x6f26ahr 3989 24 testicular testicular JJ cord-028721-x6f26ahr 3989 25 agenesis agenesis NN cord-028721-x6f26ahr 3989 26 Compensatory compensatory JJ cord-028721-x6f26ahr 3989 27 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3989 28 of of IN cord-028721-x6f26ahr 3989 29 testicle testicle NN cord-028721-x6f26ahr 3989 30 in in IN cord-028721-x6f26ahr 3989 31 unilateral unilateral JJ cord-028721-x6f26ahr 3989 32 cnyptorchidism cnyptorchidism NN cord-028721-x6f26ahr 3989 33 Impact Impact NNP cord-028721-x6f26ahr 3989 34 of of IN cord-028721-x6f26ahr 3989 35 varicocele varicocele NN cord-028721-x6f26ahr 3989 36 on on IN cord-028721-x6f26ahr 3989 37 testicular testicular JJ cord-028721-x6f26ahr 3989 38 volume volume NN cord-028721-x6f26ahr 3989 39 in in IN cord-028721-x6f26ahr 3989 40 young young JJ cord-028721-x6f26ahr 3989 41 men man NNS cord-028721-x6f26ahr 3989 42 : : : cord-028721-x6f26ahr 3989 43 signifi signifi NNP cord-028721-x6f26ahr 3989 44 cance cance NN cord-028721-x6f26ahr 3989 45 of of IN cord-028721-x6f26ahr 3989 46 compensatory compensatory JJ cord-028721-x6f26ahr 3989 47 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3989 48 of of IN cord-028721-x6f26ahr 3989 49 contralateral contralateral JJ cord-028721-x6f26ahr 3989 50 testis testis NN cord-028721-x6f26ahr 3989 51 Plasma Plasma NNP cord-028721-x6f26ahr 3989 52 LH LH NNP cord-028721-x6f26ahr 3989 53 and and CC cord-028721-x6f26ahr 3989 54 FSH fsh NN cord-028721-x6f26ahr 3989 55 response response NN cord-028721-x6f26ahr 3989 56 to to IN cord-028721-x6f26ahr 3989 57 LRH LRH NNP cord-028721-x6f26ahr 3989 58 in in IN cord-028721-x6f26ahr 3989 59 boys boy NNS cord-028721-x6f26ahr 3989 60 with with IN cord-028721-x6f26ahr 3989 61 compensatory compensatory JJ cord-028721-x6f26ahr 3989 62 testicular testicular JJ cord-028721-x6f26ahr 3989 63 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3989 64 Followup Followup NNP cord-028721-x6f26ahr 3989 65 of of IN cord-028721-x6f26ahr 3989 66 boys boy NNS cord-028721-x6f26ahr 3989 67 with with IN cord-028721-x6f26ahr 3989 68 unilateral unilateral JJ cord-028721-x6f26ahr 3989 69 compensatory compensatory JJ cord-028721-x6f26ahr 3989 70 testicular testicular JJ cord-028721-x6f26ahr 3989 71 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3989 72 Testicular Testicular NNP cord-028721-x6f26ahr 3989 73 volume volume NN cord-028721-x6f26ahr 3989 74 during during IN cord-028721-x6f26ahr 3989 75 adolencence adolencence NN cord-028721-x6f26ahr 3990 1 Unilateral unilateral JJ cord-028721-x6f26ahr 3990 2 testicular testicular JJ cord-028721-x6f26ahr 3990 3 hypertrophy hypertrophy NN cord-028721-x6f26ahr 3990 4 : : : cord-028721-x6f26ahr 3991 1 An an DT cord-028721-x6f26ahr 3991 2 apparently apparently RB cord-028721-x6f26ahr 3991 3 benign benign JJ cord-028721-x6f26ahr 3991 4 occurrence occurrence NN cord-028721-x6f26ahr 3991 5 without without IN cord-028721-x6f26ahr 3991 6 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 3991 7 Benign benign JJ cord-028721-x6f26ahr 3991 8 bilateral bilateral JJ cord-028721-x6f26ahr 3991 9 testicular testicular NN cord-028721-x6f26ahr 3991 10 enlargement enlargement NN cord-028721-x6f26ahr 3991 11 Benign benign JJ cord-028721-x6f26ahr 3991 12 macroorchidism macroorchidism NN cord-028721-x6f26ahr 3991 13 in in IN cord-028721-x6f26ahr 3991 14 a a DT cord-028721-x6f26ahr 3991 15 pubescent pubescent JJ cord-028721-x6f26ahr 3991 16 boy boy NN cord-028721-x6f26ahr 3991 17 Idiopathic idiopathic JJ cord-028721-x6f26ahr 3991 18 macroorchidism macroorchidism NN cord-028721-x6f26ahr 3991 19 Macro macro NN cord-028721-x6f26ahr 3991 20 - - HYPH cord-028721-x6f26ahr 3991 21 orchidism orchidism NN cord-028721-x6f26ahr 3991 22 : : : cord-028721-x6f26ahr 3991 23 light light NN cord-028721-x6f26ahr 3991 24 and and CC cord-028721-x6f26ahr 3991 25 electron electron NN cord-028721-x6f26ahr 3991 26 microscopic microscopic JJ cord-028721-x6f26ahr 3991 27 study study NN cord-028721-x6f26ahr 3991 28 of of IN cord-028721-x6f26ahr 3991 29 four four CD cord-028721-x6f26ahr 3991 30 cases case NNS cord-028721-x6f26ahr 3991 31 Idiopathic idiopathic VBP cord-028721-x6f26ahr 3991 32 benign benign JJ cord-028721-x6f26ahr 3991 33 bilateral bilateral JJ cord-028721-x6f26ahr 3991 34 testicular testicular JJ cord-028721-x6f26ahr 3991 35 enlargement enlargement NN cord-028721-x6f26ahr 3991 36 in in IN cord-028721-x6f26ahr 3991 37 a a DT cord-028721-x6f26ahr 3991 38 pubertal pubertal JJ cord-028721-x6f26ahr 3991 39 boy boy NN cord-028721-x6f26ahr 3991 40 : : : cord-028721-x6f26ahr 3991 41 a a DT cord-028721-x6f26ahr 3991 42 case case NN cord-028721-x6f26ahr 3991 43 report report NN cord-028721-x6f26ahr 3991 44 and and CC cord-028721-x6f26ahr 3991 45 review review NN cord-028721-x6f26ahr 3991 46 of of IN cord-028721-x6f26ahr 3991 47 literature literature NN cord-028721-x6f26ahr 3991 48 Macroorchidism Macroorchidism NNP cord-028721-x6f26ahr 3992 1 : : : cord-028721-x6f26ahr 3992 2 a a DT cord-028721-x6f26ahr 3992 3 case case NN cord-028721-x6f26ahr 3992 4 report report NN cord-028721-x6f26ahr 3992 5 Endocrine Endocrine NNP cord-028721-x6f26ahr 3992 6 and and CC cord-028721-x6f26ahr 3992 7 spermatological spermatological JJ cord-028721-x6f26ahr 3992 8 characteristics characteristic NNS cord-028721-x6f26ahr 3992 9 of of IN cord-028721-x6f26ahr 3992 10 135 135 CD cord-028721-x6f26ahr 3992 11 patients patient NNS cord-028721-x6f26ahr 3992 12 with with IN cord-028721-x6f26ahr 3992 13 bilateral bilateral JJ cord-028721-x6f26ahr 3992 14 megalotestis megalotestis NN cord-028721-x6f26ahr 3993 1 The the DT cord-028721-x6f26ahr 3993 2 Fragile Fragile NNP cord-028721-x6f26ahr 3993 3 X x NN cord-028721-x6f26ahr 3993 4 premutation premutation NN cord-028721-x6f26ahr 3993 5 : : : cord-028721-x6f26ahr 3993 6 new new JJ cord-028721-x6f26ahr 3993 7 insights insight NNS cord-028721-x6f26ahr 3993 8 and and CC cord-028721-x6f26ahr 3993 9 clinical clinical JJ cord-028721-x6f26ahr 3993 10 consequences consequence NNS cord-028721-x6f26ahr 3994 1 A a DT cord-028721-x6f26ahr 3994 2 marker marker NN cord-028721-x6f26ahr 3994 3 X x NN cord-028721-x6f26ahr 3994 4 chromosome chromosome NN cord-028721-x6f26ahr 3994 5 A a DT cord-028721-x6f26ahr 3994 6 pedigree pedigree NN cord-028721-x6f26ahr 3994 7 of of IN cord-028721-x6f26ahr 3994 8 mental mental JJ cord-028721-x6f26ahr 3994 9 defect defect NN cord-028721-x6f26ahr 3994 10 showing show VBG cord-028721-x6f26ahr 3994 11 sex sex NN cord-028721-x6f26ahr 3994 12 - - HYPH cord-028721-x6f26ahr 3994 13 linkage linkage NN cord-028721-x6f26ahr 3994 14 X X NNS cord-028721-x6f26ahr 3994 15 - - HYPH cord-028721-x6f26ahr 3994 16 linked link VBN cord-028721-x6f26ahr 3994 17 mental mental JJ cord-028721-x6f26ahr 3994 18 retardation retardation NN cord-028721-x6f26ahr 3994 19 associated associate VBN cord-028721-x6f26ahr 3994 20 with with IN cord-028721-x6f26ahr 3994 21 macroorchidism macroorchidism NN cord-028721-x6f26ahr 3994 22 Inherited inherit VBN cord-028721-x6f26ahr 3994 23 congenital congenital JJ cord-028721-x6f26ahr 3994 24 normofunctional normofunctional JJ cord-028721-x6f26ahr 3994 25 testicular testicular JJ cord-028721-x6f26ahr 3994 26 hyperplasia hyperplasia NN cord-028721-x6f26ahr 3994 27 and and CC cord-028721-x6f26ahr 3994 28 mental mental JJ cord-028721-x6f26ahr 3994 29 defi defi NNP cord-028721-x6f26ahr 3994 30 ciency ciency NNP cord-028721-x6f26ahr 3994 31 . . . cord-028721-x6f26ahr 3995 1 A a DT cord-028721-x6f26ahr 3995 2 corroborative corroborative JJ cord-028721-x6f26ahr 3995 3 study study NN cord-028721-x6f26ahr 3995 4 X X NNS cord-028721-x6f26ahr 3995 5 - - HYPH cord-028721-x6f26ahr 3995 6 linked link VBN cord-028721-x6f26ahr 3995 7 mental mental JJ cord-028721-x6f26ahr 3995 8 defi defi NNP cord-028721-x6f26ahr 3995 9 ciency ciency NNP cord-028721-x6f26ahr 3995 10 megalotestes megalotestes NNP cord-028721-x6f26ahr 3995 11 syndrome syndrome NN cord-028721-x6f26ahr 3996 1 Xlinked xlinked JJ cord-028721-x6f26ahr 3996 2 mental mental JJ cord-028721-x6f26ahr 3996 3 retardation retardation NN cord-028721-x6f26ahr 3996 4 with with IN cord-028721-x6f26ahr 3996 5 macroorchidism macroorchidism NN cord-028721-x6f26ahr 3996 6 and and CC cord-028721-x6f26ahr 3996 7 the the DT cord-028721-x6f26ahr 3996 8 fragile fragile JJ cord-028721-x6f26ahr 3996 9 site site NN cord-028721-x6f26ahr 3996 10 at at IN cord-028721-x6f26ahr 3996 11 Xq Xq NNP cord-028721-x6f26ahr 3996 12 27 27 CD cord-028721-x6f26ahr 3996 13 or or CC cord-028721-x6f26ahr 3996 14 28 28 CD cord-028721-x6f26ahr 3996 15 Familial familial JJ cord-028721-x6f26ahr 3996 16 - - HYPH cord-028721-x6f26ahr 3996 17 X x NN cord-028721-x6f26ahr 3996 18 - - HYPH cord-028721-x6f26ahr 3996 19 linked link VBN cord-028721-x6f26ahr 3996 20 mental mental JJ cord-028721-x6f26ahr 3996 21 retardation retardation NN cord-028721-x6f26ahr 3996 22 with with IN cord-028721-x6f26ahr 3996 23 a a DT cord-028721-x6f26ahr 3996 24 marker marker NN cord-028721-x6f26ahr 3996 25 X x NN cord-028721-x6f26ahr 3996 26 chromosome chromosome NN cord-028721-x6f26ahr 3996 27 and and CC cord-028721-x6f26ahr 3996 28 its -PRON- PRP$ cord-028721-x6f26ahr 3996 29 relationship relationship NN cord-028721-x6f26ahr 3997 1 to to IN cord-028721-x6f26ahr 3997 2 macroorchidism macroorchidism NNP cord-028721-x6f26ahr 3997 3 A a DT cord-028721-x6f26ahr 3997 4 recognizable recognizable JJ cord-028721-x6f26ahr 3997 5 syndrome syndrome NN cord-028721-x6f26ahr 3997 6 of of IN cord-028721-x6f26ahr 3997 7 sex sex NN cord-028721-x6f26ahr 3997 8 - - HYPH cord-028721-x6f26ahr 3997 9 linked link VBN cord-028721-x6f26ahr 3997 10 mental mental JJ cord-028721-x6f26ahr 3997 11 retardation retardation NN cord-028721-x6f26ahr 3997 12 , , , cord-028721-x6f26ahr 3997 13 large large JJ cord-028721-x6f26ahr 3997 14 testes testis NNS cord-028721-x6f26ahr 3997 15 and and CC cord-028721-x6f26ahr 3997 16 marker marker NN cord-028721-x6f26ahr 3997 17 X x NN cord-028721-x6f26ahr 3997 18 chromosome chromosome NN cord-028721-x6f26ahr 3997 19 Gonadal Gonadal NNP cord-028721-x6f26ahr 3997 20 function function NN cord-028721-x6f26ahr 3997 21 in in IN cord-028721-x6f26ahr 3997 22 men man NNS cord-028721-x6f26ahr 3997 23 with with IN cord-028721-x6f26ahr 3997 24 the the DT cord-028721-x6f26ahr 3997 25 Martin Martin NNP cord-028721-x6f26ahr 3997 26 - - HYPH cord-028721-x6f26ahr 3997 27 Bell Bell NNP cord-028721-x6f26ahr 3997 28 ( ( -LRB- cord-028721-x6f26ahr 3997 29 fragile fragile JJ cord-028721-x6f26ahr 3997 30 X x NN cord-028721-x6f26ahr 3997 31 ) ) -RRB- cord-028721-x6f26ahr 3997 32 syndrome syndrome NN cord-028721-x6f26ahr 3997 33 Spermatogenesis Spermatogenesis NNP cord-028721-x6f26ahr 3997 34 in in IN cord-028721-x6f26ahr 3997 35 two two CD cord-028721-x6f26ahr 3997 36 patients patient NNS cord-028721-x6f26ahr 3997 37 with with IN cord-028721-x6f26ahr 3997 38 the the DT cord-028721-x6f26ahr 3997 39 fragile fragile JJ cord-028721-x6f26ahr 3997 40 X x NN cord-028721-x6f26ahr 3997 41 syndrome syndrome NN cord-028721-x6f26ahr 3997 42 . . . cord-028721-x6f26ahr 3998 1 I. I. NNP cord-028721-x6f26ahr 3998 2 Histology histology NN cord-028721-x6f26ahr 3998 3 : : : cord-028721-x6f26ahr 3998 4 light light NN cord-028721-x6f26ahr 3998 5 and and CC cord-028721-x6f26ahr 3998 6 electron electron NN cord-028721-x6f26ahr 3998 7 microscopy microscopy NN cord-028721-x6f26ahr 3999 1 Spermatogenesis Spermatogenesis NNP cord-028721-x6f26ahr 3999 2 in in IN cord-028721-x6f26ahr 3999 3 two two CD cord-028721-x6f26ahr 3999 4 patients patient NNS cord-028721-x6f26ahr 3999 5 with with IN cord-028721-x6f26ahr 3999 6 the the DT cord-028721-x6f26ahr 3999 7 fragile fragile JJ cord-028721-x6f26ahr 3999 8 X x NN cord-028721-x6f26ahr 3999 9 syndrome syndrome NN cord-028721-x6f26ahr 3999 10 X x NN cord-028721-x6f26ahr 3999 11 - - HYPH cord-028721-x6f26ahr 3999 12 linked link VBN cord-028721-x6f26ahr 3999 13 mental mental JJ cord-028721-x6f26ahr 3999 14 retardation retardation NN cord-028721-x6f26ahr 3999 15 and and CC cord-028721-x6f26ahr 3999 16 an an DT cord-028721-x6f26ahr 3999 17 X x NN cord-028721-x6f26ahr 3999 18 - - NN cord-028721-x6f26ahr 3999 19 chromosome chromosome NN cord-028721-x6f26ahr 3999 20 marker marker NN cord-028721-x6f26ahr 3999 21 Population population NN cord-028721-x6f26ahr 3999 22 incidence incidence NN cord-028721-x6f26ahr 3999 23 and and CC cord-028721-x6f26ahr 3999 24 segregation segregation NN cord-028721-x6f26ahr 3999 25 ratios ratio NNS cord-028721-x6f26ahr 3999 26 in in IN cord-028721-x6f26ahr 3999 27 Martin Martin NNP cord-028721-x6f26ahr 3999 28 - - HYPH cord-028721-x6f26ahr 3999 29 Bell Bell NNP cord-028721-x6f26ahr 3999 30 syndrome syndrome NN cord-028721-x6f26ahr 3999 31 Study Study NNP cord-028721-x6f26ahr 3999 32 of of IN cord-028721-x6f26ahr 3999 33 a a DT cord-028721-x6f26ahr 3999 34 family family NN cord-028721-x6f26ahr 3999 35 with with IN cord-028721-x6f26ahr 3999 36 a a DT cord-028721-x6f26ahr 3999 37 fragile fragile JJ cord-028721-x6f26ahr 3999 38 site site NN cord-028721-x6f26ahr 3999 39 of of IN cord-028721-x6f26ahr 3999 40 the the DT cord-028721-x6f26ahr 3999 41 X x NN cord-028721-x6f26ahr 3999 42 chromosome chromosome NN cord-028721-x6f26ahr 3999 43 at at IN cord-028721-x6f26ahr 3999 44 Xq Xq NNP cord-028721-x6f26ahr 3999 45 27 27 CD cord-028721-x6f26ahr 3999 46 - - SYM cord-028721-x6f26ahr 3999 47 28 28 CD cord-028721-x6f26ahr 3999 48 without without IN cord-028721-x6f26ahr 3999 49 mental mental JJ cord-028721-x6f26ahr 3999 50 retardation retardation NN cord-028721-x6f26ahr 3999 51 Testicular Testicular NNP cord-028721-x6f26ahr 3999 52 size size NN cord-028721-x6f26ahr 3999 53 in in IN cord-028721-x6f26ahr 4000 1 fetal fetal JJ cord-028721-x6f26ahr 4000 2 fragile fragile NNP cord-028721-x6f26ahr 4000 3 X x NN cord-028721-x6f26ahr 4000 4 syndrome syndrome NN cord-028721-x6f26ahr 4000 5 A a DT cord-028721-x6f26ahr 4000 6 family family NN cord-028721-x6f26ahr 4000 7 with with IN cord-028721-x6f26ahr 4000 8 mental mental JJ cord-028721-x6f26ahr 4000 9 retardation retardation NN cord-028721-x6f26ahr 4000 10 , , , cord-028721-x6f26ahr 4000 11 variable variable JJ cord-028721-x6f26ahr 4000 12 macrocephaly macrocephaly NNP cord-028721-x6f26ahr 4000 13 and and CC cord-028721-x6f26ahr 4000 14 macroorchidism macroorchidism NN cord-028721-x6f26ahr 4000 15 , , , cord-028721-x6f26ahr 4000 16 and and CC cord-028721-x6f26ahr 4000 17 linkage linkage NN cord-028721-x6f26ahr 4000 18 to to IN cord-028721-x6f26ahr 4000 19 Xq12-q21 xq12-q21 NN cord-028721-x6f26ahr 4000 20 Testicular testicular JJ cord-028721-x6f26ahr 4000 21 enlargement enlargement NN cord-028721-x6f26ahr 4000 22 and and CC cord-028721-x6f26ahr 4000 23 elevated elevated JJ cord-028721-x6f26ahr 4000 24 serum serum NN cord-028721-x6f26ahr 4000 25 inhibin inhibin NN cord-028721-x6f26ahr 4000 26 concentrations concentration NNS cord-028721-x6f26ahr 4000 27 occur occur VBP cord-028721-x6f26ahr 4000 28 in in IN cord-028721-x6f26ahr 4000 29 patients patient NNS cord-028721-x6f26ahr 4000 30 with with IN cord-028721-x6f26ahr 4000 31 pituitary pituitary JJ cord-028721-x6f26ahr 4000 32 macroadenomas macroadenomas NNP cord-028721-x6f26ahr 4000 33 secreting secrete VBG cord-028721-x6f26ahr 4000 34 follicle follicle NN cord-028721-x6f26ahr 4000 35 stimulating stimulate VBG cord-028721-x6f26ahr 4000 36 hormone hormone NN cord-028721-x6f26ahr 4000 37 Juvenile juvenile JJ cord-028721-x6f26ahr 4000 38 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4000 39 with with IN cord-028721-x6f26ahr 4000 40 testicular testicular JJ cord-028721-x6f26ahr 4000 41 enlargement enlargement NN cord-028721-x6f26ahr 4000 42 Hipotiroidismo Hipotiroidismo NNP cord-028721-x6f26ahr 4000 43 y y NNP cord-028721-x6f26ahr 4000 44 maduración maduración NNP cord-028721-x6f26ahr 4001 1 testicular testicular NN cord-028721-x6f26ahr 4001 2 precoz precoz VBD cord-028721-x6f26ahr 4001 3 Thyroid thyroid JJ cord-028721-x6f26ahr 4001 4 hormone hormone NN cord-028721-x6f26ahr 4001 5 and and CC cord-028721-x6f26ahr 4001 6 male male JJ cord-028721-x6f26ahr 4001 7 gonadal gonadal NN cord-028721-x6f26ahr 4001 8 function function NN cord-028721-x6f26ahr 4001 9 Sexual sexual JJ cord-028721-x6f26ahr 4001 10 maturation maturation NN cord-028721-x6f26ahr 4001 11 in in IN cord-028721-x6f26ahr 4001 12 juvenile juvenile JJ cord-028721-x6f26ahr 4001 13 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4001 14 Hypothalamic Hypothalamic NNP cord-028721-x6f26ahr 4001 15 - - HYPH cord-028721-x6f26ahr 4001 16 pituitary pituitary JJ cord-028721-x6f26ahr 4001 17 gonadal gonadal JJ cord-028721-x6f26ahr 4001 18 axis axis NN cord-028721-x6f26ahr 4001 19 in in IN cord-028721-x6f26ahr 4001 20 boys boy NNS cord-028721-x6f26ahr 4001 21 with with IN cord-028721-x6f26ahr 4001 22 primary primary JJ cord-028721-x6f26ahr 4001 23 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4001 24 and and CC cord-028721-x6f26ahr 4001 25 macroorchidism macroorchidism NN cord-028721-x6f26ahr 4001 26 Thyroid thyroid JJ cord-028721-x6f26ahr 4001 27 hormones hormone NNS cord-028721-x6f26ahr 4001 28 : : : cord-028721-x6f26ahr 4001 29 their -PRON- PRP$ cord-028721-x6f26ahr 4001 30 role role NN cord-028721-x6f26ahr 4001 31 in in IN cord-028721-x6f26ahr 4001 32 testicular testicular NN cord-028721-x6f26ahr 4001 33 steroidogenesis steroidogenesis NN cord-028721-x6f26ahr 4001 34 Male male JJ cord-028721-x6f26ahr 4001 35 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4001 36 in in IN cord-028721-x6f26ahr 4001 37 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4001 38 : : : cord-028721-x6f26ahr 4002 1 A a DT cord-028721-x6f26ahr 4002 2 study study NN cord-028721-x6f26ahr 4002 3 of of IN cord-028721-x6f26ahr 4002 4 six six CD cord-028721-x6f26ahr 4002 5 cases case NNS cord-028721-x6f26ahr 4002 6 Macroorchidism Macroorchidism NNP cord-028721-x6f26ahr 4002 7 and and CC cord-028721-x6f26ahr 4002 8 testicular testicular NN cord-028721-x6f26ahr 4002 9 fi fi NN cord-028721-x6f26ahr 4002 10 brosis brosis NN cord-028721-x6f26ahr 4002 11 associated associate VBN cord-028721-x6f26ahr 4002 12 with with IN cord-028721-x6f26ahr 4002 13 autoimmune autoimmune JJ cord-028721-x6f26ahr 4002 14 thyroiditis thyroiditis NN cord-028721-x6f26ahr 4002 15 Juvenile juvenile JJ cord-028721-x6f26ahr 4002 16 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4002 17 and and CC cord-028721-x6f26ahr 4002 18 precocious precocious JJ cord-028721-x6f26ahr 4002 19 testicular testicular JJ cord-028721-x6f26ahr 4002 20 maturation maturation NN cord-028721-x6f26ahr 4003 1 Acquired acquire VBN cord-028721-x6f26ahr 4003 2 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4003 3 with with IN cord-028721-x6f26ahr 4003 4 muscular muscular JJ cord-028721-x6f26ahr 4003 5 hypertrophy hypertrophy NN cord-028721-x6f26ahr 4003 6 and and CC cord-028721-x6f26ahr 4003 7 precocious precocious JJ cord-028721-x6f26ahr 4003 8 testicular testicular JJ cord-028721-x6f26ahr 4003 9 enlargement enlargement NN cord-028721-x6f26ahr 4003 10 Regulation regulation NN cord-028721-x6f26ahr 4003 11 of of IN cord-028721-x6f26ahr 4003 12 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4003 13 - - HYPH cord-028721-x6f26ahr 4003 14 releasing release VBG cord-028721-x6f26ahr 4003 15 hormone hormone NN cord-028721-x6f26ahr 4003 16 ( ( -LRB- cord-028721-x6f26ahr 4003 17 GnRH GnRH NNP cord-028721-x6f26ahr 4003 18 ) ) -RRB- cord-028721-x6f26ahr 4003 19 gene gene NN cord-028721-x6f26ahr 4003 20 expression expression NN cord-028721-x6f26ahr 4003 21 in in IN cord-028721-x6f26ahr 4003 22 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 4003 23 neuronal neuronal JJ cord-028721-x6f26ahr 4003 24 cells cell NNS cord-028721-x6f26ahr 4003 25 Hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4003 26 - - HYPH cord-028721-x6f26ahr 4003 27 induced induce VBN cord-028721-x6f26ahr 4003 28 macroorchidism macroorchidism NN cord-028721-x6f26ahr 4003 29 : : : cord-028721-x6f26ahr 4004 1 Use use NN cord-028721-x6f26ahr 4004 2 of of IN cord-028721-x6f26ahr 4004 3 a a DT cord-028721-x6f26ahr 4004 4 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 4004 5 - - HYPH cord-028721-x6f26ahr 4004 6 hormone hormone NN cord-028721-x6f26ahr 4004 7 agonist agonist NN cord-028721-x6f26ahr 4004 8 to to TO cord-028721-x6f26ahr 4004 9 understand understand VB cord-028721-x6f26ahr 4004 10 its -PRON- PRP$ cord-028721-x6f26ahr 4004 11 mechanism mechanism NN cord-028721-x6f26ahr 4004 12 and and CC cord-028721-x6f26ahr 4004 13 augment augment VB cord-028721-x6f26ahr 4004 14 adult adult NN cord-028721-x6f26ahr 4004 15 stature stature NN cord-028721-x6f26ahr 4004 16 A a DT cord-028721-x6f26ahr 4004 17 potential potential JJ cord-028721-x6f26ahr 4004 18 novel novel NN cord-028721-x6f26ahr 4004 19 mechanism mechanism NN cord-028721-x6f26ahr 4004 20 for for IN cord-028721-x6f26ahr 4004 21 precocious precocious JJ cord-028721-x6f26ahr 4004 22 puberty puberty NN cord-028721-x6f26ahr 4004 23 in in IN cord-028721-x6f26ahr 4004 24 juvenile juvenile JJ cord-028721-x6f26ahr 4004 25 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4005 1 High high JJ cord-028721-x6f26ahr 4005 2 neonatal neonatal JJ cord-028721-x6f26ahr 4005 3 triiodothironine triiodothironine NN cord-028721-x6f26ahr 4005 4 levels level NNS cord-028721-x6f26ahr 4005 5 reduce reduce VBP cord-028721-x6f26ahr 4005 6 the the DT cord-028721-x6f26ahr 4005 7 period period NN cord-028721-x6f26ahr 4005 8 of of IN cord-028721-x6f26ahr 4005 9 Sertoli sertoli JJ cord-028721-x6f26ahr 4005 10 cell cell NN cord-028721-x6f26ahr 4005 11 proliferation proliferation NN cord-028721-x6f26ahr 4005 12 and and CC cord-028721-x6f26ahr 4005 13 accelerate accelerate VB cord-028721-x6f26ahr 4005 14 tubular tubular JJ cord-028721-x6f26ahr 4005 15 lumen lumen JJ cord-028721-x6f26ahr 4005 16 formation formation NN cord-028721-x6f26ahr 4005 17 in in IN cord-028721-x6f26ahr 4005 18 the the DT cord-028721-x6f26ahr 4005 19 rat rat NN cord-028721-x6f26ahr 4005 20 testis testis NN cord-028721-x6f26ahr 4005 21 , , , cord-028721-x6f26ahr 4005 22 and and CC cord-028721-x6f26ahr 4005 23 increase increase VB cord-028721-x6f26ahr 4005 24 serum serum NN cord-028721-x6f26ahr 4005 25 inhibin inhibin NN cord-028721-x6f26ahr 4005 26 levels level NNS cord-028721-x6f26ahr 4005 27 Increased increase VBN cord-028721-x6f26ahr 4005 28 numbers number NNS cord-028721-x6f26ahr 4005 29 of of IN cord-028721-x6f26ahr 4005 30 Sertoli Sertoli NNP cord-028721-x6f26ahr 4005 31 and and CC cord-028721-x6f26ahr 4005 32 germ germ NN cord-028721-x6f26ahr 4005 33 cells cell NNS cord-028721-x6f26ahr 4005 34 in in IN cord-028721-x6f26ahr 4005 35 adult adult NN cord-028721-x6f26ahr 4005 36 rat rat NN cord-028721-x6f26ahr 4005 37 testes testis NNS cord-028721-x6f26ahr 4005 38 induced induce VBN cord-028721-x6f26ahr 4005 39 by by IN cord-028721-x6f26ahr 4005 40 synergistic synergistic JJ cord-028721-x6f26ahr 4005 41 action action NN cord-028721-x6f26ahr 4005 42 of of IN cord-028721-x6f26ahr 4005 43 transient transient JJ cord-028721-x6f26ahr 4005 44 neonatal neonatal JJ cord-028721-x6f26ahr 4005 45 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4005 46 and and CC cord-028721-x6f26ahr 4005 47 neonatal neonatal JJ cord-028721-x6f26ahr 4005 48 hemicastration hemicastration NN cord-028721-x6f26ahr 4005 49 Tri Tri NNP cord-028721-x6f26ahr 4005 50 - - HYPH cord-028721-x6f26ahr 4005 51 iodothyronine iodothyronine NNP cord-028721-x6f26ahr 4005 52 directly directly RB cord-028721-x6f26ahr 4005 53 affects affect VBZ cord-028721-x6f26ahr 4005 54 rat rat NN cord-028721-x6f26ahr 4005 55 Sertoli Sertoli NNP cord-028721-x6f26ahr 4005 56 cell cell NN cord-028721-x6f26ahr 4005 57 proliferation proliferation NN cord-028721-x6f26ahr 4005 58 and and CC cord-028721-x6f26ahr 4005 59 differentiation differentiation NN cord-028721-x6f26ahr 4005 60 Neonatal neonatal JJ cord-028721-x6f26ahr 4005 61 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4006 1 causes cause NNS cord-028721-x6f26ahr 4006 2 delayed delay VBD cord-028721-x6f26ahr 4006 3 Sertoli sertoli JJ cord-028721-x6f26ahr 4006 4 cell cell NN cord-028721-x6f26ahr 4006 5 maturation maturation NN cord-028721-x6f26ahr 4006 6 in in IN cord-028721-x6f26ahr 4006 7 rats rat NNS cord-028721-x6f26ahr 4006 8 treated treat VBN cord-028721-x6f26ahr 4006 9 with with IN cord-028721-x6f26ahr 4006 10 propylthiouracil propylthiouracil NNS cord-028721-x6f26ahr 4006 11 : : : cord-028721-x6f26ahr 4006 12 evidence evidence NN cord-028721-x6f26ahr 4006 13 that that IN cord-028721-x6f26ahr 4006 14 the the DT cord-028721-x6f26ahr 4006 15 Sertoli Sertoli NNP cord-028721-x6f26ahr 4006 16 cell cell NN cord-028721-x6f26ahr 4006 17 controls control VBZ cord-028721-x6f26ahr 4006 18 testis testis NN cord-028721-x6f26ahr 4006 19 growth growth NN cord-028721-x6f26ahr 4006 20 Central central JJ cord-028721-x6f26ahr 4006 21 precocious precocious JJ cord-028721-x6f26ahr 4006 22 puberty puberty NN cord-028721-x6f26ahr 4006 23 . . . cord-028721-x6f26ahr 4007 1 An an DT cord-028721-x6f26ahr 4007 2 overview overview NN cord-028721-x6f26ahr 4007 3 of of IN cord-028721-x6f26ahr 4007 4 diagnosis diagnosis NN cord-028721-x6f26ahr 4007 5 , , , cord-028721-x6f26ahr 4007 6 treatment treatment NN cord-028721-x6f26ahr 4007 7 , , , cord-028721-x6f26ahr 4007 8 and and CC cord-028721-x6f26ahr 4007 9 outcome outcome VB cord-028721-x6f26ahr 4007 10 Precocious precocious JJ cord-028721-x6f26ahr 4007 11 puberty puberty NN cord-028721-x6f26ahr 4008 1 Precocious precocious JJ cord-028721-x6f26ahr 4008 2 puberty puberty NN cord-028721-x6f26ahr 4008 3 Sexual sexual JJ cord-028721-x6f26ahr 4008 4 precocity precocity NN cord-028721-x6f26ahr 4009 1 Precocious precocious JJ cord-028721-x6f26ahr 4009 2 puberty puberty NN cord-028721-x6f26ahr 4009 3 caused cause VBN cord-028721-x6f26ahr 4009 4 by by IN cord-028721-x6f26ahr 4009 5 a a DT cord-028721-x6f26ahr 4009 6 suprasellar suprasellar JJ cord-028721-x6f26ahr 4009 7 arachnoid arachnoid JJ cord-028721-x6f26ahr 4009 8 cyst cyst NN cord-028721-x6f26ahr 4009 9 . . . cord-028721-x6f26ahr 4010 1 Analysis analysis NN cord-028721-x6f26ahr 4010 2 of of IN cord-028721-x6f26ahr 4010 3 6 6 CD cord-028721-x6f26ahr 4010 4 cases case NNS cord-028721-x6f26ahr 4011 1 The the DT cord-028721-x6f26ahr 4011 2 endocrine endocrine JJ cord-028721-x6f26ahr 4011 3 spectrum spectrum NN cord-028721-x6f26ahr 4011 4 of of IN cord-028721-x6f26ahr 4011 5 arachnoid arachnoid JJ cord-028721-x6f26ahr 4011 6 cysts cyst NNS cord-028721-x6f26ahr 4011 7 in in IN cord-028721-x6f26ahr 4011 8 childhood childhood NN cord-028721-x6f26ahr 4011 9 Growth growth NN cord-028721-x6f26ahr 4011 10 , , , cord-028721-x6f26ahr 4011 11 puberty puberty NN cord-028721-x6f26ahr 4011 12 and and CC cord-028721-x6f26ahr 4011 13 hypothalamicpituitary hypothalamicpituitary JJ cord-028721-x6f26ahr 4011 14 function function NN cord-028721-x6f26ahr 4011 15 in in IN cord-028721-x6f26ahr 4011 16 children child NNS cord-028721-x6f26ahr 4011 17 with with IN cord-028721-x6f26ahr 4011 18 suprasellar suprasellar JJ cord-028721-x6f26ahr 4011 19 arachnoid arachnoid NNP cord-028721-x6f26ahr 4011 20 cyst cyst NNP cord-028721-x6f26ahr 4011 21 Aspects Aspects NNPS cord-028721-x6f26ahr 4011 22 étiologiques étiologiques NNP cord-028721-x6f26ahr 4011 23 cliniques cliniques NNPS cord-028721-x6f26ahr 4011 24 et et NNP cord-028721-x6f26ahr 4011 25 biologiques biologiques FW cord-028721-x6f26ahr 4011 26 des des NNP cord-028721-x6f26ahr 4011 27 pubertés pubertés NNP cord-028721-x6f26ahr 4011 28 précoces précoces NNP cord-028721-x6f26ahr 4011 29 d'origine d'origine NNP cord-028721-x6f26ahr 4011 30 centrale centrale NNP cord-028721-x6f26ahr 4011 31 Precocious Precocious NNP cord-028721-x6f26ahr 4011 32 puberty puberty NNP cord-028721-x6f26ahr 4011 33 following follow VBG cord-028721-x6f26ahr 4011 34 severe severe JJ cord-028721-x6f26ahr 4011 35 head head NN cord-028721-x6f26ahr 4011 36 trauma trauma NN cord-028721-x6f26ahr 4011 37 Precocious precocious JJ cord-028721-x6f26ahr 4011 38 puberty puberty NN cord-028721-x6f26ahr 4011 39 after after IN cord-028721-x6f26ahr 4011 40 traumatic traumatic JJ cord-028721-x6f26ahr 4011 41 brain brain NN cord-028721-x6f26ahr 4011 42 injury injury NN cord-028721-x6f26ahr 4011 43 Endocrine endocrine JJ cord-028721-x6f26ahr 4011 44 disorder disorder NN cord-028721-x6f26ahr 4011 45 as as IN cord-028721-x6f26ahr 4011 46 the the DT cord-028721-x6f26ahr 4011 47 only only JJ cord-028721-x6f26ahr 4011 48 sign sign NN cord-028721-x6f26ahr 4011 49 of of IN cord-028721-x6f26ahr 4011 50 chronic chronic NNP cord-028721-x6f26ahr 4011 51 ' ' `` cord-028721-x6f26ahr 4011 52 nonhypertensive nonhypertensive JJ cord-028721-x6f26ahr 4011 53 ' ' '' cord-028721-x6f26ahr 4011 54 hydrocephalus hydrocephalus NN cord-028721-x6f26ahr 4012 1 Precocious precocious JJ cord-028721-x6f26ahr 4012 2 puberty puberty NN cord-028721-x6f26ahr 4012 3 after after IN cord-028721-x6f26ahr 4012 4 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 4012 5 and and CC cord-028721-x6f26ahr 4012 6 pituitary pituitary JJ cord-028721-x6f26ahr 4012 7 irradiation irradiation NN cord-028721-x6f26ahr 4012 8 in in IN cord-028721-x6f26ahr 4012 9 young young JJ cord-028721-x6f26ahr 4012 10 children child NNS cord-028721-x6f26ahr 4013 1 Precocious precocious JJ cord-028721-x6f26ahr 4013 2 and and CC cord-028721-x6f26ahr 4013 3 premature premature JJ cord-028721-x6f26ahr 4013 4 puberty puberty NN cord-028721-x6f26ahr 4013 5 associated associate VBN cord-028721-x6f26ahr 4013 6 with with IN cord-028721-x6f26ahr 4013 7 treatment treatment NN cord-028721-x6f26ahr 4013 8 of of IN cord-028721-x6f26ahr 4013 9 acute acute JJ cord-028721-x6f26ahr 4013 10 lymphoblastic lymphoblastic JJ cord-028721-x6f26ahr 4013 11 leukaemia leukaemia NN cord-028721-x6f26ahr 4013 12 Endocrine endocrine NN cord-028721-x6f26ahr 4013 13 function function NN cord-028721-x6f26ahr 4013 14 and and CC cord-028721-x6f26ahr 4013 15 morphological morphological JJ cord-028721-x6f26ahr 4013 16 fi fi NN cord-028721-x6f26ahr 4013 17 ndings nding NNS cord-028721-x6f26ahr 4013 18 in in IN cord-028721-x6f26ahr 4013 19 patients patient NNS cord-028721-x6f26ahr 4013 20 with with IN cord-028721-x6f26ahr 4013 21 disorders disorder NNS cord-028721-x6f26ahr 4013 22 of of IN cord-028721-x6f26ahr 4013 23 the the DT cord-028721-x6f26ahr 4013 24 hypothalamopituitary hypothalamopituitary NNP cord-028721-x6f26ahr 4013 25 area area NN cord-028721-x6f26ahr 4013 26 : : : cord-028721-x6f26ahr 4013 27 a a DT cord-028721-x6f26ahr 4013 28 study study NN cord-028721-x6f26ahr 4013 29 with with IN cord-028721-x6f26ahr 4013 30 magnetic magnetic JJ cord-028721-x6f26ahr 4013 31 resonance resonance NN cord-028721-x6f26ahr 4014 1 The the DT cord-028721-x6f26ahr 4014 2 radiological radiological JJ cord-028721-x6f26ahr 4014 3 approach approach NN cord-028721-x6f26ahr 4014 4 to to IN cord-028721-x6f26ahr 4014 5 precocious precocious JJ cord-028721-x6f26ahr 4014 6 puberty puberty NN cord-028721-x6f26ahr 4015 1 MR MR NNP cord-028721-x6f26ahr 4015 2 imaging imaging NN cord-028721-x6f26ahr 4015 3 features feature NNS cord-028721-x6f26ahr 4015 4 in in IN cord-028721-x6f26ahr 4015 5 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 4015 6 hamartoma hamartoma NN cord-028721-x6f26ahr 4015 7 : : : cord-028721-x6f26ahr 4016 1 a a DT cord-028721-x6f26ahr 4016 2 report report NN cord-028721-x6f26ahr 4016 3 of of IN cord-028721-x6f26ahr 4016 4 three three CD cord-028721-x6f26ahr 4016 5 cases case NNS cord-028721-x6f26ahr 4016 6 and and CC cord-028721-x6f26ahr 4016 7 review review NN cord-028721-x6f26ahr 4016 8 of of IN cord-028721-x6f26ahr 4016 9 literature literature NN cord-028721-x6f26ahr 4016 10 Boys boy NNS cord-028721-x6f26ahr 4016 11 with with IN cord-028721-x6f26ahr 4016 12 precocious precocious JJ cord-028721-x6f26ahr 4016 13 puberty puberty NN cord-028721-x6f26ahr 4016 14 due due IN cord-028721-x6f26ahr 4016 15 to to IN cord-028721-x6f26ahr 4016 16 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 4016 17 hamartoma hamartoma NN cord-028721-x6f26ahr 4016 18 : : : cord-028721-x6f26ahr 4016 19 reproductive reproductive JJ cord-028721-x6f26ahr 4016 20 axis axis NN cord-028721-x6f26ahr 4016 21 after after IN cord-028721-x6f26ahr 4016 22 discontinuation discontinuation NN cord-028721-x6f26ahr 4016 23 of of IN cord-028721-x6f26ahr 4016 24 gonadotropinreleasing gonadotropinrelease VBG cord-028721-x6f26ahr 4016 25 hormone hormone NN cord-028721-x6f26ahr 4016 26 analog analog NN cord-028721-x6f26ahr 4016 27 therapy therapy NN cord-028721-x6f26ahr 4016 28 Etiology etiology NN cord-028721-x6f26ahr 4016 29 of of IN cord-028721-x6f26ahr 4016 30 central central JJ cord-028721-x6f26ahr 4016 31 precocious precocious JJ cord-028721-x6f26ahr 4016 32 puberty puberty NN cord-028721-x6f26ahr 4016 33 in in IN cord-028721-x6f26ahr 4016 34 males male NNS cord-028721-x6f26ahr 4016 35 : : : cord-028721-x6f26ahr 4016 36 the the DT cord-028721-x6f26ahr 4016 37 results result NNS cord-028721-x6f26ahr 4016 38 of of IN cord-028721-x6f26ahr 4016 39 the the DT cord-028721-x6f26ahr 4016 40 Italian Italian NNP cord-028721-x6f26ahr 4016 41 Study Study NNP cord-028721-x6f26ahr 4016 42 Group Group NNP cord-028721-x6f26ahr 4016 43 for for IN cord-028721-x6f26ahr 4016 44 Physiopathology Physiopathology NNP cord-028721-x6f26ahr 4016 45 of of IN cord-028721-x6f26ahr 4016 46 Puberty Puberty NNP cord-028721-x6f26ahr 4016 47 Hypothalamic Hypothalamic NNP cord-028721-x6f26ahr 4016 48 hamartoma hamartoma NN cord-028721-x6f26ahr 4016 49 : : : cord-028721-x6f26ahr 4016 50 a a DT cord-028721-x6f26ahr 4016 51 source source NN cord-028721-x6f26ahr 4016 52 References reference NNS cord-028721-x6f26ahr 4016 53 of of IN cord-028721-x6f26ahr 4016 54 luteinizing luteinizing NN cord-028721-x6f26ahr 4016 55 - - HYPH cord-028721-x6f26ahr 4016 56 hormone hormone NN cord-028721-x6f26ahr 4016 57 - - HYPH cord-028721-x6f26ahr 4016 58 releasing release VBG cord-028721-x6f26ahr 4016 59 factor factor NN cord-028721-x6f26ahr 4016 60 in in IN cord-028721-x6f26ahr 4016 61 precocious precocious JJ cord-028721-x6f26ahr 4016 62 puberty puberty NN cord-028721-x6f26ahr 4016 63 Mixed mixed JJ cord-028721-x6f26ahr 4016 64 germ germ NN cord-028721-x6f26ahr 4016 65 cell cell NN cord-028721-x6f26ahr 4016 66 tumour tumour NN cord-028721-x6f26ahr 4016 67 of of IN cord-028721-x6f26ahr 4016 68 the the DT cord-028721-x6f26ahr 4016 69 pineal pineal NN cord-028721-x6f26ahr 4016 70 region region NN cord-028721-x6f26ahr 4016 71 : : : cord-028721-x6f26ahr 4016 72 a a DT cord-028721-x6f26ahr 4016 73 case case NN cord-028721-x6f26ahr 4016 74 report report NN cord-028721-x6f26ahr 4016 75 hCG hcg NN cord-028721-x6f26ahr 4016 76 - - HYPH cord-028721-x6f26ahr 4016 77 secreting secrete VBG cord-028721-x6f26ahr 4016 78 pineal pineal NN cord-028721-x6f26ahr 4016 79 teratoma teratoma NN cord-028721-x6f26ahr 4016 80 causing cause VBG cord-028721-x6f26ahr 4016 81 precocious precocious JJ cord-028721-x6f26ahr 4016 82 puberty puberty NN cord-028721-x6f26ahr 4016 83 : : : cord-028721-x6f26ahr 4017 1 report report NN cord-028721-x6f26ahr 4017 2 of of IN cord-028721-x6f26ahr 4017 3 two two CD cord-028721-x6f26ahr 4017 4 patients patient NNS cord-028721-x6f26ahr 4017 5 and and CC cord-028721-x6f26ahr 4017 6 review review NN cord-028721-x6f26ahr 4017 7 of of IN cord-028721-x6f26ahr 4017 8 the the DT cord-028721-x6f26ahr 4017 9 literature literature NN cord-028721-x6f26ahr 4017 10 Puberty Puberty NNP cord-028721-x6f26ahr 4017 11 without without IN cord-028721-x6f26ahr 4017 12 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 4017 13 : : : cord-028721-x6f26ahr 4017 14 A a DT cord-028721-x6f26ahr 4017 15 unique unique JJ cord-028721-x6f26ahr 4017 16 mechanism mechanism NN cord-028721-x6f26ahr 4017 17 of of IN cord-028721-x6f26ahr 4017 18 sexual sexual JJ cord-028721-x6f26ahr 4017 19 development development NN cord-028721-x6f26ahr 4018 1 Gonadotropinindependent gonadotropinindependent JJ cord-028721-x6f26ahr 4018 2 familial familial JJ cord-028721-x6f26ahr 4018 3 sexual sexual JJ cord-028721-x6f26ahr 4018 4 precocity precocity NN cord-028721-x6f26ahr 4018 5 with with IN cord-028721-x6f26ahr 4018 6 premature premature JJ cord-028721-x6f26ahr 4018 7 Leydig leydig NN cord-028721-x6f26ahr 4018 8 and and CC cord-028721-x6f26ahr 4018 9 germinal germinal JJ cord-028721-x6f26ahr 4018 10 cell cell NN cord-028721-x6f26ahr 4018 11 maturation maturation NN cord-028721-x6f26ahr 4018 12 ( ( -LRB- cord-028721-x6f26ahr 4018 13 familial familial JJ cord-028721-x6f26ahr 4018 14 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 4018 15 ) ) -RRB- cord-028721-x6f26ahr 4019 1 : : : cord-028721-x6f26ahr 4019 2 Effects effect NNS cord-028721-x6f26ahr 4019 3 of of IN cord-028721-x6f26ahr 4019 4 a a DT cord-028721-x6f26ahr 4019 5 patent patent NN cord-028721-x6f26ahr 4019 6 luteinizing luteinize VBG cord-028721-x6f26ahr 4019 7 hormone hormone NN cord-028721-x6f26ahr 4019 8 - - HYPH cord-028721-x6f26ahr 4019 9 releasing release VBG cord-028721-x6f26ahr 4019 10 factor factor NN cord-028721-x6f26ahr 4019 11 agonist agonist NN cord-028721-x6f26ahr 4019 12 and and CC cord-028721-x6f26ahr 4019 13 metroxyprogesterone metroxyprogesterone NN cord-028721-x6f26ahr 4019 14 acetate acetate NN cord-028721-x6f26ahr 4019 15 therapy therapy NN cord-028721-x6f26ahr 4019 16 in in IN cord-028721-x6f26ahr 4019 17 four four CD cord-028721-x6f26ahr 4019 18 cases case NNS cord-028721-x6f26ahr 4020 1 Testicular testicular JJ cord-028721-x6f26ahr 4020 2 changes change NNS cord-028721-x6f26ahr 4020 3 in in IN cord-028721-x6f26ahr 4020 4 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 4020 5 - - HYPH cord-028721-x6f26ahr 4020 6 independent independent JJ cord-028721-x6f26ahr 4020 7 familial familial JJ cord-028721-x6f26ahr 4020 8 male male JJ cord-028721-x6f26ahr 4020 9 sexual sexual JJ cord-028721-x6f26ahr 4020 10 precocity precocity NN cord-028721-x6f26ahr 4020 11 . . . cord-028721-x6f26ahr 4021 1 Familial familial JJ cord-028721-x6f26ahr 4021 2 testotoxicosis testotoxicosis NN cord-028721-x6f26ahr 4022 1 Gonadotropin gonadotropin JJ cord-028721-x6f26ahr 4022 2 - - HYPH cord-028721-x6f26ahr 4022 3 independent independent JJ cord-028721-x6f26ahr 4022 4 precocious precocious JJ cord-028721-x6f26ahr 4022 5 puberty puberty NN cord-028721-x6f26ahr 4022 6 due due IN cord-028721-x6f26ahr 4022 7 to to IN cord-028721-x6f26ahr 4022 8 luteinizing luteinize VBG cord-028721-x6f26ahr 4022 9 hormone hormone NN cord-028721-x6f26ahr 4022 10 receptor receptor NN cord-028721-x6f26ahr 4022 11 mutations mutation NNS cord-028721-x6f26ahr 4022 12 in in IN cord-028721-x6f26ahr 4022 13 Brazillian brazillian JJ cord-028721-x6f26ahr 4022 14 boys boy NNS cord-028721-x6f26ahr 4022 15 : : : cord-028721-x6f26ahr 4022 16 A a DT cord-028721-x6f26ahr 4022 17 novel novel NN cord-028721-x6f26ahr 4022 18 constitutively constitutively RB cord-028721-x6f26ahr 4022 19 activating activate VBG cord-028721-x6f26ahr 4022 20 mutation mutation NN cord-028721-x6f26ahr 4022 21 in in IN cord-028721-x6f26ahr 4022 22 the the DT cord-028721-x6f26ahr 4022 23 fi fi NN cord-028721-x6f26ahr 4022 24 rst rst NN cord-028721-x6f26ahr 4022 25 transmembrane transmembrane NN cord-028721-x6f26ahr 4022 26 helix helix NN cord-028721-x6f26ahr 4022 27 Activating activate VBG cord-028721-x6f26ahr 4022 28 mutations mutation NNS cord-028721-x6f26ahr 4022 29 in in IN cord-028721-x6f26ahr 4022 30 the the DT cord-028721-x6f26ahr 4022 31 LH LH NNP cord-028721-x6f26ahr 4022 32 receptor receptor NN cord-028721-x6f26ahr 4022 33 gene gene NN cord-028721-x6f26ahr 4022 34 : : : cord-028721-x6f26ahr 4022 35 a a DT cord-028721-x6f26ahr 4022 36 human human JJ cord-028721-x6f26ahr 4022 37 model model NN cord-028721-x6f26ahr 4022 38 of of IN cord-028721-x6f26ahr 4022 39 non non JJ cord-028721-x6f26ahr 4022 40 FSH fsh NN cord-028721-x6f26ahr 4022 41 - - HYPH cord-028721-x6f26ahr 4022 42 dependent dependent JJ cord-028721-x6f26ahr 4022 43 inhibin inhibin NN cord-028721-x6f26ahr 4022 44 production production NN cord-028721-x6f26ahr 4022 45 and and CC cord-028721-x6f26ahr 4022 46 germ germ NN cord-028721-x6f26ahr 4022 47 cell cell NN cord-028721-x6f26ahr 4022 48 maturation maturation NN cord-028721-x6f26ahr 4022 49 Mutational Mutational NNP cord-028721-x6f26ahr 4022 50 analysis analysis NN cord-028721-x6f26ahr 4022 51 of of IN cord-028721-x6f26ahr 4022 52 the the DT cord-028721-x6f26ahr 4022 53 luteinizing luteinize VBG cord-028721-x6f26ahr 4022 54 hormone hormone NN cord-028721-x6f26ahr 4022 55 receptor receptor NN cord-028721-x6f26ahr 4022 56 gene gene NN cord-028721-x6f26ahr 4022 57 in in IN cord-028721-x6f26ahr 4022 58 two two CD cord-028721-x6f26ahr 4022 59 individuals individual NNS cord-028721-x6f26ahr 4022 60 with with IN cord-028721-x6f26ahr 4022 61 Leydig leydig NN cord-028721-x6f26ahr 4022 62 cell cell NN cord-028721-x6f26ahr 4022 63 tumors tumor NNS cord-028721-x6f26ahr 4022 64 Tumor Tumor NNP cord-028721-x6f26ahr 4022 65 de de NNP cord-028721-x6f26ahr 4022 66 células células NNP cord-028721-x6f26ahr 4022 67 de de NNP cord-028721-x6f26ahr 4022 68 Leydig Leydig NNP cord-028721-x6f26ahr 4022 69 con con NN cord-028721-x6f26ahr 4022 70 pseudopubertad pseudopubertad NN cord-028721-x6f26ahr 4022 71 precoz precoz NNP cord-028721-x6f26ahr 4022 72 Leydig Leydig NNP cord-028721-x6f26ahr 4022 73 cell cell NN cord-028721-x6f26ahr 4022 74 tumor tumor NN cord-028721-x6f26ahr 4022 75 in in IN cord-028721-x6f26ahr 4022 76 a a DT cord-028721-x6f26ahr 4022 77 child child NN cord-028721-x6f26ahr 4022 78 with with IN cord-028721-x6f26ahr 4022 79 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 4022 80 maturation maturation NN cord-028721-x6f26ahr 4022 81 and and CC cord-028721-x6f26ahr 4023 1 no no DT cord-028721-x6f26ahr 4023 2 pseudoprecocious pseudoprecocious NNP cord-028721-x6f26ahr 4023 3 puberty puberty . cord-028721-x6f26ahr 4024 1 An an DT cord-028721-x6f26ahr 4024 2 aromatase aromatase NN cord-028721-x6f26ahr 4024 3 - - HYPH cord-028721-x6f26ahr 4024 4 producing produce VBG cord-028721-x6f26ahr 4024 5 sex sex NN cord-028721-x6f26ahr 4024 6 - - HYPH cord-028721-x6f26ahr 4024 7 cord cord NN cord-028721-x6f26ahr 4024 8 tumor tumor NN cord-028721-x6f26ahr 4024 9 resulting result VBG cord-028721-x6f26ahr 4024 10 in in IN cord-028721-x6f26ahr 4024 11 prepubertal prepubertal JJ cord-028721-x6f26ahr 4024 12 gynecomastia gynecomastia NN cord-028721-x6f26ahr 4024 13 Sertoli sertoli JJ cord-028721-x6f26ahr 4024 14 cell cell NN cord-028721-x6f26ahr 4024 15 tumour tumour NN cord-028721-x6f26ahr 4024 16 in in IN cord-028721-x6f26ahr 4024 17 a a DT cord-028721-x6f26ahr 4024 18 boy boy NN cord-028721-x6f26ahr 4024 19 with with IN cord-028721-x6f26ahr 4025 1 Peutz Peutz NNP cord-028721-x6f26ahr 4025 2 - - HYPH cord-028721-x6f26ahr 4025 3 Jeghers Jeghers NNP cord-028721-x6f26ahr 4025 4 syndrome syndrome NN cord-028721-x6f26ahr 4025 5 Carney Carney NNP cord-028721-x6f26ahr 4025 6 complex complex NN cord-028721-x6f26ahr 4025 7 : : : cord-028721-x6f26ahr 4025 8 the the DT cord-028721-x6f26ahr 4025 9 complex complex NN cord-028721-x6f26ahr 4025 10 of of IN cord-028721-x6f26ahr 4025 11 mixomas mixomas NNP cord-028721-x6f26ahr 4025 12 , , , cord-028721-x6f26ahr 4025 13 spotty spotty JJ cord-028721-x6f26ahr 4025 14 pigmentation pigmentation NN cord-028721-x6f26ahr 4025 15 , , , cord-028721-x6f26ahr 4025 16 endocrine endocrine JJ cord-028721-x6f26ahr 4025 17 overactivity overactivity NN cord-028721-x6f26ahr 4025 18 , , , cord-028721-x6f26ahr 4025 19 and and CC cord-028721-x6f26ahr 4025 20 schwannomas schwannomas NNP cord-028721-x6f26ahr 4026 1 Virilising virilise VBG cord-028721-x6f26ahr 4026 2 adrenal adrenal JJ cord-028721-x6f26ahr 4026 3 cortical cortical JJ cord-028721-x6f26ahr 4026 4 tumours tumour NNS cord-028721-x6f26ahr 4026 5 in in IN cord-028721-x6f26ahr 4026 6 children child NNS cord-028721-x6f26ahr 4027 1 Virilizing virilize VBG cord-028721-x6f26ahr 4027 2 adrenal adrenal JJ cord-028721-x6f26ahr 4027 3 cortical cortical JJ cord-028721-x6f26ahr 4027 4 carcinoma carcinoma NN cord-028721-x6f26ahr 4027 5 with with IN cord-028721-x6f26ahr 4027 6 hypertrophy hypertrophy NN cord-028721-x6f26ahr 4027 7 of of IN cord-028721-x6f26ahr 4027 8 spermatic spermatic JJ cord-028721-x6f26ahr 4027 9 tubules tubule NNS cord-028721-x6f26ahr 4027 10 in in IN cord-028721-x6f26ahr 4027 11 childhood childhood NN cord-028721-x6f26ahr 4027 12 Bilateral bilateral JJ cord-028721-x6f26ahr 4027 13 testicular testicular JJ cord-028721-x6f26ahr 4027 14 tumours tumour NNS cord-028721-x6f26ahr 4027 15 in in IN cord-028721-x6f26ahr 4027 16 congenital congenital JJ cord-028721-x6f26ahr 4027 17 adrenal adrenal JJ cord-028721-x6f26ahr 4027 18 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4027 19 : : : cord-028721-x6f26ahr 4028 1 A a DT cord-028721-x6f26ahr 4028 2 continuing continue VBG cord-028721-x6f26ahr 4028 3 diagnostic diagnostic JJ cord-028721-x6f26ahr 4028 4 and and CC cord-028721-x6f26ahr 4028 5 therapeutic therapeutic JJ cord-028721-x6f26ahr 4028 6 dilemma dilemma NN cord-028721-x6f26ahr 4028 7 Hepatoblastoma Hepatoblastoma NNP cord-028721-x6f26ahr 4028 8 presenting present VBG cord-028721-x6f26ahr 4028 9 as as IN cord-028721-x6f26ahr 4028 10 isosexual isosexual JJ cord-028721-x6f26ahr 4028 11 precocity precocity NN cord-028721-x6f26ahr 4028 12 . . . cord-028721-x6f26ahr 4029 1 The the DT cord-028721-x6f26ahr 4029 2 clinical clinical JJ cord-028721-x6f26ahr 4029 3 importance importance NN cord-028721-x6f26ahr 4029 4 of of IN cord-028721-x6f26ahr 4029 5 histologic histologic JJ cord-028721-x6f26ahr 4029 6 and and CC cord-028721-x6f26ahr 4029 7 serologic serologic NN cord-028721-x6f26ahr 4029 8 parameters parameter NNS cord-028721-x6f26ahr 4029 9 Gonadotropin Gonadotropin NNP cord-028721-x6f26ahr 4029 10 - - HYPH cord-028721-x6f26ahr 4029 11 secreting secrete VBG cord-028721-x6f26ahr 4029 12 pineal pineal NN cord-028721-x6f26ahr 4029 13 teratoma teratoma NN cord-028721-x6f26ahr 4029 14 causing cause VBG cord-028721-x6f26ahr 4029 15 precocious precocious JJ cord-028721-x6f26ahr 4029 16 puberty puberty NN cord-028721-x6f26ahr 4030 1 The the DT cord-028721-x6f26ahr 4030 2 P450 p450 JJ cord-028721-x6f26ahr 4030 3 gene gene NN cord-028721-x6f26ahr 4030 4 superfamily superfamily NN cord-028721-x6f26ahr 4030 5 : : : cord-028721-x6f26ahr 4030 6 updated update VBN cord-028721-x6f26ahr 4030 7 listing listing NN cord-028721-x6f26ahr 4030 8 of of IN cord-028721-x6f26ahr 4030 9 all all DT cord-028721-x6f26ahr 4030 10 genes gene NNS cord-028721-x6f26ahr 4030 11 and and CC cord-028721-x6f26ahr 4030 12 recommended recommend VBD cord-028721-x6f26ahr 4030 13 nomenclature nomenclature NN cord-028721-x6f26ahr 4030 14 for for IN cord-028721-x6f26ahr 4030 15 the the DT cord-028721-x6f26ahr 4030 16 chromosomal chromosomal JJ cord-028721-x6f26ahr 4030 17 loci locus NNS cord-028721-x6f26ahr 4030 18 Human Human NNP cord-028721-x6f26ahr 4030 19 aromatase aromatase NN cord-028721-x6f26ahr 4030 20 : : : cord-028721-x6f26ahr 4030 21 cDNA cdna NN cord-028721-x6f26ahr 4030 22 cloning cloning NN cord-028721-x6f26ahr 4030 23 , , , cord-028721-x6f26ahr 4030 24 Southern southern JJ cord-028721-x6f26ahr 4030 25 blot blot NN cord-028721-x6f26ahr 4030 26 analysis analysis NN cord-028721-x6f26ahr 4030 27 , , , cord-028721-x6f26ahr 4030 28 and and CC cord-028721-x6f26ahr 4030 29 assignment assignment NN cord-028721-x6f26ahr 4030 30 of of IN cord-028721-x6f26ahr 4030 31 the the DT cord-028721-x6f26ahr 4030 32 gene gene NN cord-028721-x6f26ahr 4030 33 to to TO cord-028721-x6f26ahr 4030 34 chromosome chromosome VB cord-028721-x6f26ahr 4030 35 15 15 CD cord-028721-x6f26ahr 4030 36 Familial familial JJ cord-028721-x6f26ahr 4030 37 hyperestrogenism hyperestrogenism NN cord-028721-x6f26ahr 4030 38 in in IN cord-028721-x6f26ahr 4030 39 both both DT cord-028721-x6f26ahr 4030 40 sexes sex NNS cord-028721-x6f26ahr 4030 41 : : : cord-028721-x6f26ahr 4030 42 clinical clinical JJ cord-028721-x6f26ahr 4030 43 , , , cord-028721-x6f26ahr 4030 44 hormonal hormonal JJ cord-028721-x6f26ahr 4030 45 , , , cord-028721-x6f26ahr 4030 46 and and CC cord-028721-x6f26ahr 4030 47 molecular molecular JJ cord-028721-x6f26ahr 4030 48 studies study NNS cord-028721-x6f26ahr 4030 49 of of IN cord-028721-x6f26ahr 4030 50 two two CD cord-028721-x6f26ahr 4030 51 siblings sibling NNS cord-028721-x6f26ahr 4030 52 The the DT cord-028721-x6f26ahr 4030 53 aromatase aromatase JJ cord-028721-x6f26ahr 4030 54 excess excess JJ cord-028721-x6f26ahr 4030 55 syndrome syndrome NN cord-028721-x6f26ahr 4030 56 is be VBZ cord-028721-x6f26ahr 4030 57 associated associate VBN cord-028721-x6f26ahr 4030 58 with with IN cord-028721-x6f26ahr 4030 59 feminization feminization NN cord-028721-x6f26ahr 4030 60 of of IN cord-028721-x6f26ahr 4030 61 both both DT cord-028721-x6f26ahr 4030 62 sexes sex NNS cord-028721-x6f26ahr 4030 63 and and CC cord-028721-x6f26ahr 4030 64 autosomal autosomal JJ cord-028721-x6f26ahr 4030 65 dominant dominant JJ cord-028721-x6f26ahr 4030 66 transmission transmission NN cord-028721-x6f26ahr 4030 67 of of IN cord-028721-x6f26ahr 4030 68 aberrant aberrant JJ cord-028721-x6f26ahr 4030 69 P450 p450 JJ cord-028721-x6f26ahr 4030 70 aromatase aromatase NN cord-028721-x6f26ahr 4030 71 gene gene NN cord-028721-x6f26ahr 4030 72 transcription transcription NN cord-028721-x6f26ahr 4030 73 Aromatase Aromatase NNP cord-028721-x6f26ahr 4030 74 defi defi NN cord-028721-x6f26ahr 4030 75 ciency ciency NN cord-028721-x6f26ahr 4030 76 caused cause VBN cord-028721-x6f26ahr 4030 77 by by IN cord-028721-x6f26ahr 4030 78 a a DT cord-028721-x6f26ahr 4030 79 novel novel NN cord-028721-x6f26ahr 4030 80 P450arom p450arom NN cord-028721-x6f26ahr 4030 81 gene gene NN cord-028721-x6f26ahr 4030 82 mutation mutation NN cord-028721-x6f26ahr 4030 83 : : : cord-028721-x6f26ahr 4030 84 impact impact NN cord-028721-x6f26ahr 4030 85 of of IN cord-028721-x6f26ahr 4030 86 absent absent JJ cord-028721-x6f26ahr 4030 87 estrogen estrogen NN cord-028721-x6f26ahr 4030 88 production production NN cord-028721-x6f26ahr 4030 89 on on IN cord-028721-x6f26ahr 4030 90 serum serum NN cord-028721-x6f26ahr 4030 91 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4030 92 concentration concentration NN cord-028721-x6f26ahr 4030 93 in in IN cord-028721-x6f26ahr 4030 94 a a DT cord-028721-x6f26ahr 4030 95 boy boy NN cord-028721-x6f26ahr 4030 96 Aromatase Aromatase NNP cord-028721-x6f26ahr 4030 97 defi defi NN cord-028721-x6f26ahr 4030 98 ciency ciency NN cord-028721-x6f26ahr 4030 99 in in IN cord-028721-x6f26ahr 4030 100 male male JJ cord-028721-x6f26ahr 4030 101 and and CC cord-028721-x6f26ahr 4030 102 female female JJ cord-028721-x6f26ahr 4030 103 siblings sibling NNS cord-028721-x6f26ahr 4030 104 caused cause VBN cord-028721-x6f26ahr 4030 105 by by IN cord-028721-x6f26ahr 4030 106 a a DT cord-028721-x6f26ahr 4030 107 novel novel JJ cord-028721-x6f26ahr 4030 108 mutation mutation NN cord-028721-x6f26ahr 4030 109 and and CC cord-028721-x6f26ahr 4030 110 the the DT cord-028721-x6f26ahr 4030 111 physiological physiological JJ cord-028721-x6f26ahr 4030 112 role role NN cord-028721-x6f26ahr 4030 113 of of IN cord-028721-x6f26ahr 4030 114 estrogens estrogen NNS cord-028721-x6f26ahr 4030 115 Effect effect NN cord-028721-x6f26ahr 4030 116 of of IN cord-028721-x6f26ahr 4030 117 testosterone testosterone NN cord-028721-x6f26ahr 4030 118 and and CC cord-028721-x6f26ahr 4030 119 estradiol estradiol NN cord-028721-x6f26ahr 4030 120 in in IN cord-028721-x6f26ahr 4030 121 a a DT cord-028721-x6f26ahr 4030 122 man man NN cord-028721-x6f26ahr 4030 123 with with IN cord-028721-x6f26ahr 4030 124 aromatase aromatase NNP cord-028721-x6f26ahr 4030 125 defi defi NNP cord-028721-x6f26ahr 4030 126 ciency ciency NNP cord-028721-x6f26ahr 4030 127 Estrogen Estrogen NNP cord-028721-x6f26ahr 4030 128 : : : cord-028721-x6f26ahr 4030 129 consequences consequence NNS cord-028721-x6f26ahr 4030 130 and and CC cord-028721-x6f26ahr 4030 131 implications implication NNS cord-028721-x6f26ahr 4030 132 of of IN cord-028721-x6f26ahr 4030 133 human human JJ cord-028721-x6f26ahr 4030 134 mutations mutation NNS cord-028721-x6f26ahr 4030 135 in in IN cord-028721-x6f26ahr 4030 136 synthesis synthesis NN cord-028721-x6f26ahr 4030 137 and and CC cord-028721-x6f26ahr 4030 138 action action NN cord-028721-x6f26ahr 4030 139 Primary primary JJ cord-028721-x6f26ahr 4030 140 testicular testicular JJ cord-028721-x6f26ahr 4030 141 abnormalities abnormality NNS cord-028721-x6f26ahr 4030 142 causing cause VBG cord-028721-x6f26ahr 4030 143 precocious precocious JJ cord-028721-x6f26ahr 4030 144 puberty puberty NN cord-028721-x6f26ahr 4030 145 Leydig leydig NN cord-028721-x6f26ahr 4030 146 cell cell NN cord-028721-x6f26ahr 4030 147 tumor tumor NN cord-028721-x6f26ahr 4030 148 , , , cord-028721-x6f26ahr 4030 149 Leydig Leydig NNP cord-028721-x6f26ahr 4030 150 cell cell NN cord-028721-x6f26ahr 4030 151 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4030 152 , , , cord-028721-x6f26ahr 4030 153 and and CC cord-028721-x6f26ahr 4030 154 adrenal adrenal JJ cord-028721-x6f26ahr 4030 155 rest rest NN cord-028721-x6f26ahr 4030 156 tumor tumor NN cord-028721-x6f26ahr 4030 157 Focal focal JJ cord-028721-x6f26ahr 4030 158 lobular lobular JJ cord-028721-x6f26ahr 4030 159 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4030 160 and and CC cord-028721-x6f26ahr 4030 161 pubertal pubertal JJ cord-028721-x6f26ahr 4030 162 acceleration acceleration NN cord-028721-x6f26ahr 4030 163 associated associate VBN cord-028721-x6f26ahr 4030 164 with with IN cord-028721-x6f26ahr 4030 165 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 4030 166 Leydig Leydig NNP cord-028721-x6f26ahr 4030 167 cell cell NN cord-028721-x6f26ahr 4030 168 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4030 169 McCune McCune NNP cord-028721-x6f26ahr 4030 170 - - HYPH cord-028721-x6f26ahr 4030 171 Albright Albright NNP cord-028721-x6f26ahr 4030 172 syndrome syndrome NN cord-028721-x6f26ahr 4030 173 in in IN cord-028721-x6f26ahr 4030 174 a a DT cord-028721-x6f26ahr 4030 175 boy boy NN cord-028721-x6f26ahr 4030 176 may may MD cord-028721-x6f26ahr 4030 177 present present VB cord-028721-x6f26ahr 4030 178 with with IN cord-028721-x6f26ahr 4030 179 a a DT cord-028721-x6f26ahr 4030 180 monolateral monolateral JJ cord-028721-x6f26ahr 4030 181 macroorchidism macroorchidism NN cord-028721-x6f26ahr 4030 182 as as IN cord-028721-x6f26ahr 4030 183 an an DT cord-028721-x6f26ahr 4030 184 early early JJ cord-028721-x6f26ahr 4030 185 and and CC cord-028721-x6f26ahr 4030 186 isolated isolate VBN cord-028721-x6f26ahr 4030 187 clinical clinical JJ cord-028721-x6f26ahr 4030 188 manifestation manifestation NN cord-028721-x6f26ahr 4030 189 Macroorchidism Macroorchidism NNP cord-028721-x6f26ahr 4030 190 due due IN cord-028721-x6f26ahr 4030 191 to to IN cord-028721-x6f26ahr 4030 192 autonomous autonomous JJ cord-028721-x6f26ahr 4030 193 hyperfunction hyperfunction NN cord-028721-x6f26ahr 4030 194 of of IN cord-028721-x6f26ahr 4030 195 Sertoli Sertoli NNP cord-028721-x6f26ahr 4030 196 cells cell NNS cord-028721-x6f26ahr 4030 197 and and CC cord-028721-x6f26ahr 4031 1 G(s)alpha G(s)alpha NNP cord-028721-x6f26ahr 4031 2 gene gene NNP cord-028721-x6f26ahr 4031 3 mutation mutation NN cord-028721-x6f26ahr 4031 4 : : : cord-028721-x6f26ahr 4031 5 an an DT cord-028721-x6f26ahr 4031 6 unusual unusual JJ cord-028721-x6f26ahr 4031 7 expression expression NN cord-028721-x6f26ahr 4031 8 of of IN cord-028721-x6f26ahr 4031 9 McCune McCune NNP cord-028721-x6f26ahr 4031 10 - - HYPH cord-028721-x6f26ahr 4031 11 Albright Albright NNP cord-028721-x6f26ahr 4031 12 syndrome syndrome NN cord-028721-x6f26ahr 4031 13 in in IN cord-028721-x6f26ahr 4031 14 a a DT cord-028721-x6f26ahr 4031 15 prepubertal prepubertal JJ cord-028721-x6f26ahr 4031 16 boy boy NN cord-028721-x6f26ahr 4031 17 McCune McCune NNP cord-028721-x6f26ahr 4031 18 - - HYPH cord-028721-x6f26ahr 4031 19 Albright Albright NNP cord-028721-x6f26ahr 4031 20 syndrome syndrome NN cord-028721-x6f26ahr 4031 21 in in IN cord-028721-x6f26ahr 4031 22 a a DT cord-028721-x6f26ahr 4031 23 male male JJ cord-028721-x6f26ahr 4031 24 child child NN cord-028721-x6f26ahr 4031 25 : : : cord-028721-x6f26ahr 4031 26 A a DT cord-028721-x6f26ahr 4031 27 clinical clinical JJ cord-028721-x6f26ahr 4031 28 and and CC cord-028721-x6f26ahr 4031 29 endocrinologic endocrinologic JJ cord-028721-x6f26ahr 4031 30 enigma enigma NN cord-028721-x6f26ahr 4031 31 Anomalies Anomalies NNPS cord-028721-x6f26ahr 4031 32 of of IN cord-028721-x6f26ahr 4031 33 the the DT cord-028721-x6f26ahr 4031 34 testicle testicle NN cord-028721-x6f26ahr 4031 35 Preperitoneal Preperitoneal NNP cord-028721-x6f26ahr 4031 36 ectopic ectopic JJ cord-028721-x6f26ahr 4031 37 testis testis NN cord-028721-x6f26ahr 4031 38 : : : cord-028721-x6f26ahr 4032 1 a a DT cord-028721-x6f26ahr 4032 2 case case NN cord-028721-x6f26ahr 4032 3 report report NN cord-028721-x6f26ahr 4032 4 Ectopia Ectopia NNP cord-028721-x6f26ahr 4032 5 epidídimo epidídimo JJ cord-028721-x6f26ahr 4032 6 - - HYPH cord-028721-x6f26ahr 4032 7 perineal perineal JJ cord-028721-x6f26ahr 4032 8 Testículo Testículo NNP cord-028721-x6f26ahr 4032 9 ectópico ectópico NN cord-028721-x6f26ahr 4033 1 perineal perineal JJ cord-028721-x6f26ahr 4033 2 Perineal Perineal NNP cord-028721-x6f26ahr 4033 3 testicle testicle NN cord-028721-x6f26ahr 4033 4 Crossed cross VBD cord-028721-x6f26ahr 4033 5 ectopic ectopic JJ cord-028721-x6f26ahr 4033 6 testis testis NN cord-028721-x6f26ahr 4033 7 : : : cord-028721-x6f26ahr 4033 8 a a DT cord-028721-x6f26ahr 4033 9 case case NN cord-028721-x6f26ahr 4033 10 report report NN cord-028721-x6f26ahr 4033 11 and and CC cord-028721-x6f26ahr 4033 12 review review NN cord-028721-x6f26ahr 4033 13 of of IN cord-028721-x6f26ahr 4033 14 the the DT cord-028721-x6f26ahr 4033 15 literature literature NN cord-028721-x6f26ahr 4033 16 Crossed cross VBD cord-028721-x6f26ahr 4033 17 ectopic ectopic JJ cord-028721-x6f26ahr 4033 18 testis testis NN cord-028721-x6f26ahr 4033 19 . . . cord-028721-x6f26ahr 4034 1 Case case NN cord-028721-x6f26ahr 4034 2 report report NN cord-028721-x6f26ahr 4034 3 and and CC cord-028721-x6f26ahr 4034 4 review review NN cord-028721-x6f26ahr 4035 1 Transverse transverse JJ cord-028721-x6f26ahr 4035 2 testicular testicular NN cord-028721-x6f26ahr 4035 3 ectopia ectopia NN cord-028721-x6f26ahr 4035 4 Crossed cross VBD cord-028721-x6f26ahr 4035 5 ectopic ectopic JJ cord-028721-x6f26ahr 4035 6 testis testis NN cord-028721-x6f26ahr 4035 7 with with IN cord-028721-x6f26ahr 4035 8 common common JJ cord-028721-x6f26ahr 4035 9 vas vas NNP cord-028721-x6f26ahr 4035 10 deferens deferen NNS cord-028721-x6f26ahr 4035 11 Crossed cross VBD cord-028721-x6f26ahr 4035 12 testicular testicular NN cord-028721-x6f26ahr 4035 13 ectopia ectopia NN cord-028721-x6f26ahr 4035 14 detected detect VBN cord-028721-x6f26ahr 4035 15 by by IN cord-028721-x6f26ahr 4035 16 laparoscopy laparoscopy RB cord-028721-x6f26ahr 4036 1 Transverse transverse JJ cord-028721-x6f26ahr 4036 2 testicular testicular NNP cord-028721-x6f26ahr 4036 3 ectopia ectopia NN cord-028721-x6f26ahr 4036 4 : : : cord-028721-x6f26ahr 4037 1 a a DT cord-028721-x6f26ahr 4037 2 case case NN cord-028721-x6f26ahr 4037 3 report report NN cord-028721-x6f26ahr 4037 4 Crossed cross VBD cord-028721-x6f26ahr 4037 5 testicular testicular JJ cord-028721-x6f26ahr 4037 6 ectopia ectopia NN cord-028721-x6f26ahr 4037 7 in in IN cord-028721-x6f26ahr 4037 8 association association NN cord-028721-x6f26ahr 4037 9 with with IN cord-028721-x6f26ahr 4037 10 double double JJ cord-028721-x6f26ahr 4037 11 incomplete incomplete JJ cord-028721-x6f26ahr 4037 12 testicular testicular NN cord-028721-x6f26ahr 4037 13 descent descent NN cord-028721-x6f26ahr 4037 14 Two two CD cord-028721-x6f26ahr 4037 15 rare rare JJ cord-028721-x6f26ahr 4037 16 genital genital JJ cord-028721-x6f26ahr 4037 17 abnormalities abnormality NNS cord-028721-x6f26ahr 4037 18 : : : cord-028721-x6f26ahr 4038 1 Crossed cross VBN cord-028721-x6f26ahr 4038 2 testicular testicular NNP cord-028721-x6f26ahr 4038 3 and and CC cord-028721-x6f26ahr 4038 4 scrototesticular scrototesticular NNP cord-028721-x6f26ahr 4039 1 ectopia ectopia NNP cord-028721-x6f26ahr 4039 2 Transverse Transverse NNP cord-028721-x6f26ahr 4039 3 testicular testicular NNP cord-028721-x6f26ahr 4039 4 ectopia ectopia NN cord-028721-x6f26ahr 4039 5 associated associate VBN cord-028721-x6f26ahr 4039 6 with with IN cord-028721-x6f26ahr 4039 7 persistent persistent JJ cord-028721-x6f26ahr 4039 8 Müllerian müllerian JJ cord-028721-x6f26ahr 4039 9 duct duct NN cord-028721-x6f26ahr 4039 10 syndrome syndrome NN cord-028721-x6f26ahr 4039 11 . . . cord-028721-x6f26ahr 4040 1 A a DT cord-028721-x6f26ahr 4040 2 case case NN cord-028721-x6f26ahr 4040 3 report report NN cord-028721-x6f26ahr 4040 4 The the DT cord-028721-x6f26ahr 4040 5 persistent persistent JJ cord-028721-x6f26ahr 4040 6 müllerian müllerian JJ cord-028721-x6f26ahr 4040 7 duct duct NN cord-028721-x6f26ahr 4040 8 syndrome syndrome NN cord-028721-x6f26ahr 4040 9 : : : cord-028721-x6f26ahr 4040 10 a a DT cord-028721-x6f26ahr 4040 11 rare rare JJ cord-028721-x6f26ahr 4040 12 cause cause NN cord-028721-x6f26ahr 4040 13 of of IN cord-028721-x6f26ahr 4040 14 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4040 15 Mixed mixed JJ cord-028721-x6f26ahr 4040 16 germ germ NN cord-028721-x6f26ahr 4040 17 cell cell NN cord-028721-x6f26ahr 4040 18 tumor tumor NN cord-028721-x6f26ahr 4040 19 after after IN cord-028721-x6f26ahr 4040 20 bilateral bilateral JJ cord-028721-x6f26ahr 4040 21 orchidopexy orchidopexy NN cord-028721-x6f26ahr 4040 22 in in IN cord-028721-x6f26ahr 4040 23 persistent persistent JJ cord-028721-x6f26ahr 4040 24 Müllerian müllerian JJ cord-028721-x6f26ahr 4040 25 duct duct NN cord-028721-x6f26ahr 4040 26 syndrome syndrome NN cord-028721-x6f26ahr 4040 27 with with IN cord-028721-x6f26ahr 4040 28 transverse transverse JJ cord-028721-x6f26ahr 4040 29 testicular testicular NNP cord-028721-x6f26ahr 4040 30 ectopia ectopia NN cord-028721-x6f26ahr 4040 31 Two two CD cord-028721-x6f26ahr 4040 32 rare rare JJ cord-028721-x6f26ahr 4040 33 cases case NNS cord-028721-x6f26ahr 4040 34 of of IN cord-028721-x6f26ahr 4040 35 ectopic ectopic JJ cord-028721-x6f26ahr 4040 36 testes testis NNS cord-028721-x6f26ahr 4041 1 Subumbilical Subumbilical NNP cord-028721-x6f26ahr 4041 2 ectopic ectopic JJ cord-028721-x6f26ahr 4041 3 testis testis NN cord-028721-x6f26ahr 4041 4 Exstrophy Exstrophy NNP cord-028721-x6f26ahr 4041 5 of of IN cord-028721-x6f26ahr 4041 6 the the DT cord-028721-x6f26ahr 4041 7 testis testis NN cord-028721-x6f26ahr 4041 8 Testicular testicular JJ cord-028721-x6f26ahr 4041 9 dislocation dislocation NN cord-028721-x6f26ahr 4041 10 after after IN cord-028721-x6f26ahr 4041 11 scrotal scrotal JJ cord-028721-x6f26ahr 4041 12 trauma trauma NN cord-028721-x6f26ahr 4041 13 Cystic cystic JJ cord-028721-x6f26ahr 4041 14 dysplasia dysplasia NN cord-028721-x6f26ahr 4041 15 of of IN cord-028721-x6f26ahr 4041 16 the the DT cord-028721-x6f26ahr 4041 17 testis testis NN cord-028721-x6f26ahr 4041 18 : : : cord-028721-x6f26ahr 4041 19 a a DT cord-028721-x6f26ahr 4041 20 unique unique JJ cord-028721-x6f26ahr 4041 21 anomaly anomaly NN cord-028721-x6f26ahr 4041 22 studied study VBN cord-028721-x6f26ahr 4041 23 by by IN cord-028721-x6f26ahr 4041 24 microdissection microdissection NN cord-028721-x6f26ahr 4041 25 Cystic cystic JJ cord-028721-x6f26ahr 4041 26 dysplasia dysplasia NN cord-028721-x6f26ahr 4041 27 of of IN cord-028721-x6f26ahr 4041 28 the the DT cord-028721-x6f26ahr 4041 29 rete rete NN cord-028721-x6f26ahr 4041 30 testis testis NN cord-028721-x6f26ahr 4041 31 . . . cord-028721-x6f26ahr 4042 1 Case case NN cord-028721-x6f26ahr 4042 2 report report VB cord-028721-x6f26ahr 4042 3 Cystic cystic JJ cord-028721-x6f26ahr 4042 4 dysplasia dysplasia NN cord-028721-x6f26ahr 4042 5 of of IN cord-028721-x6f26ahr 4042 6 the the DT cord-028721-x6f26ahr 4042 7 rete rete NN cord-028721-x6f26ahr 4042 8 testis testis NN cord-028721-x6f26ahr 4042 9 associated associate VBN cord-028721-x6f26ahr 4042 10 to to IN cord-028721-x6f26ahr 4042 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4042 12 : : : cord-028721-x6f26ahr 4042 13 a a DT cord-028721-x6f26ahr 4042 14 case case NN cord-028721-x6f26ahr 4042 15 report report NN cord-028721-x6f26ahr 4042 16 Cystic cystic JJ cord-028721-x6f26ahr 4042 17 dysplasia dysplasia NN cord-028721-x6f26ahr 4042 18 of of IN cord-028721-x6f26ahr 4042 19 the the DT cord-028721-x6f26ahr 4042 20 testis testis NN cord-028721-x6f26ahr 4042 21 : : : cord-028721-x6f26ahr 4042 22 sonographic sonographic JJ cord-028721-x6f26ahr 4042 23 and and CC cord-028721-x6f26ahr 4042 24 pathologic pathologic JJ cord-028721-x6f26ahr 4042 25 fi fi NN cord-028721-x6f26ahr 4042 26 ndings nding NNS cord-028721-x6f26ahr 4042 27 Cystic Cystic NNP cord-028721-x6f26ahr 4042 28 testicular testicular JJ cord-028721-x6f26ahr 4042 29 lesions lesion NNS cord-028721-x6f26ahr 4042 30 in in IN cord-028721-x6f26ahr 4042 31 the the DT cord-028721-x6f26ahr 4042 32 pediatric pediatric JJ cord-028721-x6f26ahr 4042 33 population population NN cord-028721-x6f26ahr 4043 1 The the DT cord-028721-x6f26ahr 4043 2 human human JJ cord-028721-x6f26ahr 4043 3 rete rete NN cord-028721-x6f26ahr 4043 4 testis testis NN cord-028721-x6f26ahr 4043 5 The the DT cord-028721-x6f26ahr 4043 6 rete rete NN cord-028721-x6f26ahr 4043 7 testis testis NN cord-028721-x6f26ahr 4043 8 in in IN cord-028721-x6f26ahr 4043 9 man man NN cord-028721-x6f26ahr 4043 10 : : : cord-028721-x6f26ahr 4043 11 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4043 12 aspects aspect NNS cord-028721-x6f26ahr 4044 1 The the DT cord-028721-x6f26ahr 4044 2 mammalian mammalian JJ cord-028721-x6f26ahr 4044 3 rete rete NN cord-028721-x6f26ahr 4044 4 testis testis NN cord-028721-x6f26ahr 4044 5 . . . cord-028721-x6f26ahr 4045 1 A a DT cord-028721-x6f26ahr 4045 2 morphological morphological JJ cord-028721-x6f26ahr 4045 3 examination examination NN cord-028721-x6f26ahr 4045 4 Cystic cystic JJ cord-028721-x6f26ahr 4045 5 displasia displasia NN cord-028721-x6f26ahr 4045 6 of of IN cord-028721-x6f26ahr 4045 7 the the DT cord-028721-x6f26ahr 4045 8 testis testis NN cord-028721-x6f26ahr 4045 9 : : : cord-028721-x6f26ahr 4045 10 light light NN cord-028721-x6f26ahr 4045 11 and and CC cord-028721-x6f26ahr 4045 12 electron electron NN cord-028721-x6f26ahr 4045 13 microscopic microscopic JJ cord-028721-x6f26ahr 4045 14 study study NN cord-028721-x6f26ahr 4045 15 of of IN cord-028721-x6f26ahr 4045 16 three three CD cord-028721-x6f26ahr 4045 17 cases case NNS cord-028721-x6f26ahr 4045 18 Cystic cystic JJ cord-028721-x6f26ahr 4045 19 dysplasia dysplasia NN cord-028721-x6f26ahr 4045 20 of of IN cord-028721-x6f26ahr 4045 21 the the DT cord-028721-x6f26ahr 4045 22 testis testis NN cord-028721-x6f26ahr 4045 23 associated associate VBN cord-028721-x6f26ahr 4045 24 with with IN cord-028721-x6f26ahr 4045 25 multicystic multicystic JJ cord-028721-x6f26ahr 4045 26 dysplasia dysplasia NN cord-028721-x6f26ahr 4045 27 of of IN cord-028721-x6f26ahr 4045 28 the the DT cord-028721-x6f26ahr 4045 29 kidney kidney NN cord-028721-x6f26ahr 4045 30 Ectasia Ectasia NNP cord-028721-x6f26ahr 4045 31 of of IN cord-028721-x6f26ahr 4045 32 the the DT cord-028721-x6f26ahr 4045 33 rete rete NN cord-028721-x6f26ahr 4045 34 testis testis NN cord-028721-x6f26ahr 4045 35 with with IN cord-028721-x6f26ahr 4045 36 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 4045 37 renal renal JJ cord-028721-x6f26ahr 4045 38 agenesis agenesis NN cord-028721-x6f26ahr 4045 39 Cystic cystic JJ cord-028721-x6f26ahr 4045 40 dysplasia dysplasia NN cord-028721-x6f26ahr 4045 41 of of IN cord-028721-x6f26ahr 4045 42 the the DT cord-028721-x6f26ahr 4045 43 testis testis NN cord-028721-x6f26ahr 4045 44 Cystic cystic JJ cord-028721-x6f26ahr 4045 45 dysplasia dysplasia NN cord-028721-x6f26ahr 4045 46 of of IN cord-028721-x6f26ahr 4045 47 testis testis NN cord-028721-x6f26ahr 4045 48 Coffi Coffi NNP cord-028721-x6f26ahr 4045 49 n n NNP cord-028721-x6f26ahr 4045 50 CM CM NNP cord-028721-x6f26ahr 4045 51 . . . cord-028721-x6f26ahr 4046 1 Cystic cystic JJ cord-028721-x6f26ahr 4046 2 testicular testicular JJ cord-028721-x6f26ahr 4046 3 lesions lesion NNS cord-028721-x6f26ahr 4046 4 in in IN cord-028721-x6f26ahr 4046 5 the the DT cord-028721-x6f26ahr 4046 6 pediatric pediatric JJ cord-028721-x6f26ahr 4046 7 population population NN cord-028721-x6f26ahr 4046 8 Cystic Cystic NNP cord-028721-x6f26ahr 4046 9 dysplasia dysplasia NN cord-028721-x6f26ahr 4046 10 of of IN cord-028721-x6f26ahr 4046 11 the the DT cord-028721-x6f26ahr 4046 12 testis testis NN cord-028721-x6f26ahr 4046 13 with with IN cord-028721-x6f26ahr 4046 14 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 4046 15 renal renal JJ cord-028721-x6f26ahr 4046 16 agenesis agenesis NN cord-028721-x6f26ahr 4046 17 . . . cord-028721-x6f26ahr 4047 1 A a DT cord-028721-x6f26ahr 4047 2 case case NN cord-028721-x6f26ahr 4047 3 report report NN cord-028721-x6f26ahr 4047 4 and and CC cord-028721-x6f26ahr 4047 5 review review NN cord-028721-x6f26ahr 4047 6 of of IN cord-028721-x6f26ahr 4047 7 the the DT cord-028721-x6f26ahr 4047 8 literature literature NN cord-028721-x6f26ahr 4048 1 Conservative conservative JJ cord-028721-x6f26ahr 4048 2 managemet managemet NN cord-028721-x6f26ahr 4048 3 of of IN cord-028721-x6f26ahr 4048 4 cystic cystic JJ cord-028721-x6f26ahr 4048 5 dysplasia dysplasia NN cord-028721-x6f26ahr 4048 6 of of IN cord-028721-x6f26ahr 4048 7 the the DT cord-028721-x6f26ahr 4048 8 testis testis NN cord-028721-x6f26ahr 4048 9 Testicular testicular JJ cord-028721-x6f26ahr 4048 10 cystic cystic JJ cord-028721-x6f26ahr 4048 11 dysplasia dysplasia NN cord-028721-x6f26ahr 4048 12 : : : cord-028721-x6f26ahr 4049 1 evaluation evaluation NN cord-028721-x6f26ahr 4049 2 of of IN cord-028721-x6f26ahr 4049 3 3 3 CD cord-028721-x6f26ahr 4049 4 new new JJ cord-028721-x6f26ahr 4049 5 cases case NNS cord-028721-x6f26ahr 4049 6 treated treat VBN cord-028721-x6f26ahr 4049 7 without without IN cord-028721-x6f26ahr 4049 8 surgery surgery NN cord-028721-x6f26ahr 4049 9 Cystic cystic JJ cord-028721-x6f26ahr 4049 10 dysplasia dysplasia NN cord-028721-x6f26ahr 4049 11 of of IN cord-028721-x6f26ahr 4049 12 rete rete NN cord-028721-x6f26ahr 4049 13 testis testis NN cord-028721-x6f26ahr 4049 14 associated associate VBN cord-028721-x6f26ahr 4049 15 with with IN cord-028721-x6f26ahr 4049 16 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 4049 17 renal renal JJ cord-028721-x6f26ahr 4049 18 agenesis agenesis NN cord-028721-x6f26ahr 4049 19 . . . cord-028721-x6f26ahr 4050 1 Case case NN cord-028721-x6f26ahr 4050 2 report report VB cord-028721-x6f26ahr 4051 1 Fetal fetal JJ cord-028721-x6f26ahr 4051 2 gonadoblastoid gonadoblastoid JJ cord-028721-x6f26ahr 4051 3 testicular testicular NN cord-028721-x6f26ahr 4051 4 dysplasia dysplasia NN cord-028721-x6f26ahr 4052 1 Gonadoblastoid gonadoblastoid JJ cord-028721-x6f26ahr 4052 2 testicular testicular JJ cord-028721-x6f26ahr 4052 3 dysplasia dysplasia NN cord-028721-x6f26ahr 4052 4 in in IN cord-028721-x6f26ahr 4052 5 Walker Walker NNP cord-028721-x6f26ahr 4052 6 - - HYPH cord-028721-x6f26ahr 4052 7 Warburg Warburg NNP cord-028721-x6f26ahr 4052 8 syndrome syndrome NN cord-028721-x6f26ahr 4053 1 Fetal fetal JJ cord-028721-x6f26ahr 4053 2 gonadoblastoid gonadoblastoid JJ cord-028721-x6f26ahr 4053 3 testicular testicular JJ cord-028721-x6f26ahr 4053 4 dysplasia dysplasia NN cord-028721-x6f26ahr 4053 5 : : : cord-028721-x6f26ahr 4053 6 a a DT cord-028721-x6f26ahr 4053 7 focal focal JJ cord-028721-x6f26ahr 4053 8 failure failure NN cord-028721-x6f26ahr 4053 9 of of IN cord-028721-x6f26ahr 4053 10 testicular testicular JJ cord-028721-x6f26ahr 4053 11 development development NN cord-028721-x6f26ahr 4053 12 Frequency Frequency NNP cord-028721-x6f26ahr 4053 13 of of IN cord-028721-x6f26ahr 4053 14 so so RB cord-028721-x6f26ahr 4053 15 - - HYPH cord-028721-x6f26ahr 4053 16 called call VBN cord-028721-x6f26ahr 4053 17 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 4053 18 or or CC cord-028721-x6f26ahr 4053 19 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4053 20 zones zone NNS cord-028721-x6f26ahr 4053 21 in in IN cord-028721-x6f26ahr 4053 22 scrotal scrotal NN cord-028721-x6f26ahr 4053 23 and and CC cord-028721-x6f26ahr 4053 24 otherwise otherwise RB cord-028721-x6f26ahr 4053 25 normal normal JJ cord-028721-x6f26ahr 4053 26 testes testis NNS cord-028721-x6f26ahr 4054 1 Androgen androgen NN cord-028721-x6f26ahr 4054 2 receptor receptor NN cord-028721-x6f26ahr 4054 3 expression expression NN cord-028721-x6f26ahr 4054 4 in in IN cord-028721-x6f26ahr 4054 5 Sertoli Sertoli NNP cord-028721-x6f26ahr 4054 6 cells cell NNS cord-028721-x6f26ahr 4054 7 as as IN cord-028721-x6f26ahr 4054 8 a a DT cord-028721-x6f26ahr 4054 9 function function NN cord-028721-x6f26ahr 4054 10 of of IN cord-028721-x6f26ahr 4054 11 seminiferous seminiferous JJ cord-028721-x6f26ahr 4054 12 tubule tubule NN cord-028721-x6f26ahr 4054 13 maturation maturation NN cord-028721-x6f26ahr 4054 14 in in IN cord-028721-x6f26ahr 4054 15 the the DT cord-028721-x6f26ahr 4054 16 human human JJ cord-028721-x6f26ahr 4054 17 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4054 18 testis testis NN cord-028721-x6f26ahr 4054 19 Congenital Congenital NNP cord-028721-x6f26ahr 4054 20 testicular testicular NNP cord-028721-x6f26ahr 4054 21 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 4054 22 Congenital Congenital NNP cord-028721-x6f26ahr 4054 23 testicular testicular NNP cord-028721-x6f26ahr 4054 24 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 4054 25 in in IN cord-028721-x6f26ahr 4054 26 Noonan Noonan NNP cord-028721-x6f26ahr 4054 27 's 's POS cord-028721-x6f26ahr 4054 28 syndrome syndrome NN cord-028721-x6f26ahr 4054 29 Congenital Congenital NNP cord-028721-x6f26ahr 4054 30 testicular testicular NNP cord-028721-x6f26ahr 4054 31 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 4054 32 in in IN cord-028721-x6f26ahr 4054 33 children child NNS cord-028721-x6f26ahr 4054 34 with with IN cord-028721-x6f26ahr 4054 35 otherwise otherwise RB cord-028721-x6f26ahr 4054 36 normal normal JJ cord-028721-x6f26ahr 4054 37 testes testis NNS cord-028721-x6f26ahr 4055 1 Macromicroscopischeskoe Macromicroscopischeskoe NNP cord-028721-x6f26ahr 4055 2 is be VBZ cord-028721-x6f26ahr 4055 3 sledavanie sledavanie NNP cord-028721-x6f26ahr 4055 4 vnutriorgannoi vnutriorgannoi NNP cord-028721-x6f26ahr 4055 5 limfaticheskoi limfaticheskoi NNP cord-028721-x6f26ahr 4055 6 sistemy sistemy NNP cord-028721-x6f26ahr 4055 7 muzhskoi muzhskoi NNP cord-028721-x6f26ahr 4055 8 polovoi polovoi NNP cord-028721-x6f26ahr 4055 9 zhelezy zhelezy NNP cord-028721-x6f26ahr 4055 10 [ [ -LRB- cord-028721-x6f26ahr 4055 11 Macro/ Macro/ NNP cord-028721-x6f26ahr 4055 12 microscopic microscopic JJ cord-028721-x6f26ahr 4055 13 study study NN cord-028721-x6f26ahr 4055 14 of of IN cord-028721-x6f26ahr 4055 15 intraorgan intraorgan NNP cord-028721-x6f26ahr 4055 16 lymphatic lymphatic NNP cord-028721-x6f26ahr 4055 17 system system NN cord-028721-x6f26ahr 4055 18 of of IN cord-028721-x6f26ahr 4055 19 male male JJ cord-028721-x6f26ahr 4055 20 gonad gonad NN cord-028721-x6f26ahr 4055 21 in in IN cord-028721-x6f26ahr 4055 22 man man NN cord-028721-x6f26ahr 4055 23 Distribution Distribution NNP cord-028721-x6f26ahr 4055 24 and and CC cord-028721-x6f26ahr 4055 25 fi fi NNP cord-028721-x6f26ahr 4055 26 ne ne NNP cord-028721-x6f26ahr 4055 27 structure structure NN cord-028721-x6f26ahr 4055 28 of of IN cord-028721-x6f26ahr 4055 29 the the DT cord-028721-x6f26ahr 4055 30 lymphatic lymphatic JJ cord-028721-x6f26ahr 4055 31 system system NN cord-028721-x6f26ahr 4055 32 in in IN cord-028721-x6f26ahr 4055 33 the the DT cord-028721-x6f26ahr 4055 34 human human JJ cord-028721-x6f26ahr 4055 35 testis testis NN cord-028721-x6f26ahr 4055 36 Lymph lymph NN cord-028721-x6f26ahr 4055 37 vascular vascular JJ cord-028721-x6f26ahr 4055 38 system system NN cord-028721-x6f26ahr 4055 39 of of IN cord-028721-x6f26ahr 4055 40 the the DT cord-028721-x6f26ahr 4055 41 interstitial interstitial JJ cord-028721-x6f26ahr 4055 42 tissue tissue NN cord-028721-x6f26ahr 4055 43 of of IN cord-028721-x6f26ahr 4055 44 the the DT cord-028721-x6f26ahr 4055 45 testis testis NN cord-028721-x6f26ahr 4055 46 as as IN cord-028721-x6f26ahr 4055 47 revealed reveal VBN cord-028721-x6f26ahr 4055 48 by by IN cord-028721-x6f26ahr 4055 49 electron electron NN cord-028721-x6f26ahr 4055 50 microscopy microscopy NN cord-028721-x6f26ahr 4055 51 Epididymal Epididymal NNP cord-028721-x6f26ahr 4055 52 lymphangiectasis lymphangiectasis NN cord-028721-x6f26ahr 4055 53 Tumors tumor NNS cord-028721-x6f26ahr 4055 54 and and CC cord-028721-x6f26ahr 4055 55 cysts cyst NNS cord-028721-x6f26ahr 4055 56 of of IN cord-028721-x6f26ahr 4055 57 the the DT cord-028721-x6f26ahr 4055 58 paratesticular paratesticular NNP cord-028721-x6f26ahr 4055 59 region region NN cord-028721-x6f26ahr 4055 60 Complex Complex NNP cord-028721-x6f26ahr 4055 61 multilocular multilocular JJ cord-028721-x6f26ahr 4055 62 cystic cystic JJ cord-028721-x6f26ahr 4055 63 lesion lesion NN cord-028721-x6f26ahr 4055 64 of of IN cord-028721-x6f26ahr 4055 65 rete rete NNP cord-028721-x6f26ahr 4055 66 testis testis NN cord-028721-x6f26ahr 4055 67 , , , cord-028721-x6f26ahr 4055 68 accompanied accompany VBN cord-028721-x6f26ahr 4055 69 by by IN cord-028721-x6f26ahr 4055 70 smooth smooth JJ cord-028721-x6f26ahr 4055 71 muscle muscle NN cord-028721-x6f26ahr 4055 72 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4055 73 , , , cord-028721-x6f26ahr 4055 74 mimicking mimic VBG cord-028721-x6f26ahr 4055 75 intratesticular intratesticular JJ cord-028721-x6f26ahr 4055 76 Leydig Leydig NNP cord-028721-x6f26ahr 4055 77 cell cell NN cord-028721-x6f26ahr 4055 78 neoplasm neoplasm NN cord-028721-x6f26ahr 4055 79 Smooth smooth JJ cord-028721-x6f26ahr 4055 80 muscle muscle NN cord-028721-x6f26ahr 4055 81 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4055 82 of of IN cord-028721-x6f26ahr 4055 83 the the DT cord-028721-x6f26ahr 4055 84 testicular testicular NN cord-028721-x6f26ahr 4055 85 adnexa adnexa NNS cord-028721-x6f26ahr 4055 86 clinically clinically RB cord-028721-x6f26ahr 4055 87 mimicking mimic VBG cord-028721-x6f26ahr 4055 88 neoplasia neoplasia NN cord-028721-x6f26ahr 4055 89 . . . cord-028721-x6f26ahr 4056 1 Clinicopathologic Clinicopathologic NNP cord-028721-x6f26ahr 4056 2 study study NN cord-028721-x6f26ahr 4056 3 of of IN cord-028721-x6f26ahr 4056 4 sixteen sixteen CD cord-028721-x6f26ahr 4056 5 cases case NNS cord-028721-x6f26ahr 4057 1 Myoepithelial myoepithelial JJ cord-028721-x6f26ahr 4057 2 hamartoma hamartoma NN cord-028721-x6f26ahr 4057 3 of of IN cord-028721-x6f26ahr 4057 4 the the DT cord-028721-x6f26ahr 4057 5 small small JJ cord-028721-x6f26ahr 4057 6 bowel bowel NN cord-028721-x6f26ahr 4057 7 : : : cord-028721-x6f26ahr 4057 8 report report NN cord-028721-x6f26ahr 4057 9 of of IN cord-028721-x6f26ahr 4057 10 a a DT cord-028721-x6f26ahr 4057 11 case case NN cord-028721-x6f26ahr 4058 1 Focal focal JJ cord-028721-x6f26ahr 4058 2 muscular muscular JJ cord-028721-x6f26ahr 4058 3 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4058 4 of of IN cord-028721-x6f26ahr 4058 5 the the DT cord-028721-x6f26ahr 4058 6 trachea trachea NN cord-028721-x6f26ahr 4058 7 Ectopic ectopic JJ cord-028721-x6f26ahr 4058 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 4058 9 tubules tubule NNS cord-028721-x6f26ahr 4058 10 in in IN cord-028721-x6f26ahr 4058 11 the the DT cord-028721-x6f26ahr 4058 12 tunica tunica NNP cord-028721-x6f26ahr 4058 13 albuginea albuginea NNP cord-028721-x6f26ahr 4058 14 of of IN cord-028721-x6f26ahr 4058 15 normal normal JJ cord-028721-x6f26ahr 4058 16 and and CC cord-028721-x6f26ahr 4058 17 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4058 18 testes testis NNS cord-028721-x6f26ahr 4058 19 Pseudocysts Pseudocysts NNPS cord-028721-x6f26ahr 4058 20 of of IN cord-028721-x6f26ahr 4058 21 the the DT cord-028721-x6f26ahr 4058 22 tunica tunica NNP cord-028721-x6f26ahr 4058 23 albuginea albuginea NNP cord-028721-x6f26ahr 4058 24 : : : cord-028721-x6f26ahr 4058 25 Benign benign JJ cord-028721-x6f26ahr 4058 26 invasion invasion NN cord-028721-x6f26ahr 4058 27 by by IN cord-028721-x6f26ahr 4058 28 testicular testicular JJ cord-028721-x6f26ahr 4058 29 tubules tubule NNS cord-028721-x6f26ahr 4058 30 Development Development NNP cord-028721-x6f26ahr 4058 31 of of IN cord-028721-x6f26ahr 4058 32 the the DT cord-028721-x6f26ahr 4058 33 testis testis NN cord-028721-x6f26ahr 4058 34 from from IN cord-028721-x6f26ahr 4058 35 birth birth NN cord-028721-x6f26ahr 4058 36 to to IN cord-028721-x6f26ahr 4058 37 puberty puberty NN cord-028721-x6f26ahr 4058 38 Testosterone testosterone NN cord-028721-x6f26ahr 4058 39 immunoexpression immunoexpression NN cord-028721-x6f26ahr 4058 40 in in IN cord-028721-x6f26ahr 4058 41 human human JJ cord-028721-x6f26ahr 4058 42 Leydig Leydig NNP cord-028721-x6f26ahr 4058 43 cells cell NNS cord-028721-x6f26ahr 4058 44 of of IN cord-028721-x6f26ahr 4058 45 the the DT cord-028721-x6f26ahr 4058 46 tunica tunica NNP cord-028721-x6f26ahr 4058 47 albugiena albugiena NNP cord-028721-x6f26ahr 4058 48 testis testis NN cord-028721-x6f26ahr 4058 49 and and CC cord-028721-x6f26ahr 4058 50 spermatic spermatic JJ cord-028721-x6f26ahr 4058 51 cord cord NN cord-028721-x6f26ahr 4058 52 . . . cord-028721-x6f26ahr 4059 1 A a DT cord-028721-x6f26ahr 4059 2 quantitative quantitative JJ cord-028721-x6f26ahr 4059 3 study study NN cord-028721-x6f26ahr 4059 4 in in IN cord-028721-x6f26ahr 4059 5 normal normal JJ cord-028721-x6f26ahr 4059 6 fetuses fetus NNS cord-028721-x6f26ahr 4059 7 , , , cord-028721-x6f26ahr 4059 8 young young JJ cord-028721-x6f26ahr 4059 9 adults adult NNS cord-028721-x6f26ahr 4059 10 , , , cord-028721-x6f26ahr 4059 11 elderly elderly JJ cord-028721-x6f26ahr 4059 12 men man NNS cord-028721-x6f26ahr 4059 13 and and CC cord-028721-x6f26ahr 4059 14 patients patient NNS cord-028721-x6f26ahr 4059 15 with with IN cord-028721-x6f26ahr 4059 16 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4060 1 Giant giant JJ cord-028721-x6f26ahr 4060 2 interstitial interstitial JJ cord-028721-x6f26ahr 4060 3 cells cell NNS cord-028721-x6f26ahr 4060 4 and and CC cord-028721-x6f26ahr 4060 5 extraparenchymal extraparenchymal JJ cord-028721-x6f26ahr 4060 6 interstitial interstitial JJ cord-028721-x6f26ahr 4060 7 cells cell NNS cord-028721-x6f26ahr 4060 8 of of IN cord-028721-x6f26ahr 4060 9 the the DT cord-028721-x6f26ahr 4060 10 human human JJ cord-028721-x6f26ahr 4060 11 testis testis NN cord-028721-x6f26ahr 4061 1 The the DT cord-028721-x6f26ahr 4061 2 infi infi NNP cord-028721-x6f26ahr 4061 3 ltrative ltrative NNP cord-028721-x6f26ahr 4061 4 activity activity NN cord-028721-x6f26ahr 4061 5 of of IN cord-028721-x6f26ahr 4061 6 Leydig Leydig NNP cord-028721-x6f26ahr 4061 7 cells cell NNS cord-028721-x6f26ahr 4061 8 Relation relation NN cord-028721-x6f26ahr 4061 9 of of IN cord-028721-x6f26ahr 4061 10 Leydig Leydig NNP cord-028721-x6f26ahr 4061 11 cells cell NNS cord-028721-x6f26ahr 4061 12 in in IN cord-028721-x6f26ahr 4061 13 the the DT cord-028721-x6f26ahr 4061 14 human human JJ cord-028721-x6f26ahr 4061 15 testicle testicle NN cord-028721-x6f26ahr 4061 16 to to IN cord-028721-x6f26ahr 4061 17 the the DT cord-028721-x6f26ahr 4061 18 tubules tubule NNS cord-028721-x6f26ahr 4061 19 and and CC cord-028721-x6f26ahr 4061 20 testicular testicular NN cord-028721-x6f26ahr 4061 21 function function VBP cord-028721-x6f26ahr 4061 22 A a DT cord-028721-x6f26ahr 4061 23 histological histological JJ cord-028721-x6f26ahr 4061 24 study study NN cord-028721-x6f26ahr 4061 25 of of IN cord-028721-x6f26ahr 4061 26 extraparenchymal extraparenchymal NNP cord-028721-x6f26ahr 4061 27 Leydig Leydig NNP cord-028721-x6f26ahr 4061 28 - - HYPH cord-028721-x6f26ahr 4061 29 like like JJ cord-028721-x6f26ahr 4061 30 cells cell NNS cord-028721-x6f26ahr 4062 1 Über Über NNP cord-028721-x6f26ahr 4062 2 die die VBP cord-028721-x6f26ahr 4062 3 Zwischenzellen Zwischenzellen NNP cord-028721-x6f26ahr 4062 4 des des XX cord-028721-x6f26ahr 4063 1 Hodens Hodens NNP cord-028721-x6f26ahr 4063 2 Zur Zur NNP cord-028721-x6f26ahr 4064 1 pathologischen pathologischen NNP cord-028721-x6f26ahr 4064 2 Anatomie Anatomie NNP cord-028721-x6f26ahr 4064 3 der der NNP cord-028721-x6f26ahr 4064 4 Leydig Leydig NNP cord-028721-x6f26ahr 4064 5 Zelle Zelle NNP cord-028721-x6f26ahr 4064 6 Leydig Leydig NNP cord-028721-x6f26ahr 4064 7 cells cell NNS cord-028721-x6f26ahr 4064 8 within within IN cord-028721-x6f26ahr 4064 9 the the DT cord-028721-x6f26ahr 4064 10 lamina lamina JJ cord-028721-x6f26ahr 4064 11 propria propria NN cord-028721-x6f26ahr 4064 12 of of IN cord-028721-x6f26ahr 4064 13 seminiferous seminiferous JJ cord-028721-x6f26ahr 4064 14 tubules tubule NNS cord-028721-x6f26ahr 4064 15 in in IN cord-028721-x6f26ahr 4064 16 four four CD cord-028721-x6f26ahr 4064 17 patients patient NNS cord-028721-x6f26ahr 4064 18 with with IN cord-028721-x6f26ahr 4064 19 azoospermia azoospermia NN cord-028721-x6f26ahr 4064 20 Ectopic Ectopic NNP cord-028721-x6f26ahr 4064 21 Leydig Leydig NNP cord-028721-x6f26ahr 4064 22 cells cell NNS cord-028721-x6f26ahr 4064 23 in in IN cord-028721-x6f26ahr 4064 24 seminiferous seminiferous JJ cord-028721-x6f26ahr 4064 25 tubules tubule NNS cord-028721-x6f26ahr 4064 26 of of IN cord-028721-x6f26ahr 4064 27 an an DT cord-028721-x6f26ahr 4064 28 infertile infertile JJ cord-028721-x6f26ahr 4064 29 human human JJ cord-028721-x6f26ahr 4064 30 male male NN cord-028721-x6f26ahr 4064 31 with with IN cord-028721-x6f26ahr 4064 32 a a DT cord-028721-x6f26ahr 4064 33 chromosomal chromosomal JJ cord-028721-x6f26ahr 4064 34 aberration aberration NN cord-028721-x6f26ahr 4064 35 Leydig leydig NN cord-028721-x6f26ahr 4064 36 cells cell NNS cord-028721-x6f26ahr 4064 37 within within IN cord-028721-x6f26ahr 4064 38 the the DT cord-028721-x6f26ahr 4064 39 spermatogenic spermatogenic NNP cord-028721-x6f26ahr 4064 40 seminiferous seminiferous JJ cord-028721-x6f26ahr 4064 41 tubules tubule NNS cord-028721-x6f26ahr 4064 42 Immunohistochemical Immunohistochemical NNP cord-028721-x6f26ahr 4064 43 and and CC cord-028721-x6f26ahr 4064 44 quantitative quantitative JJ cord-028721-x6f26ahr 4064 45 study study NN cord-028721-x6f26ahr 4064 46 of of IN cord-028721-x6f26ahr 4064 47 interstitial interstitial JJ cord-028721-x6f26ahr 4064 48 and and CC cord-028721-x6f26ahr 4064 49 intratubular intratubular JJ cord-028721-x6f26ahr 4064 50 Leydig Leydig NNP cord-028721-x6f26ahr 4064 51 cells cell NNS cord-028721-x6f26ahr 4064 52 in in IN cord-028721-x6f26ahr 4064 53 normal normal JJ cord-028721-x6f26ahr 4064 54 men man NNS cord-028721-x6f26ahr 4064 55 , , , cord-028721-x6f26ahr 4064 56 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4064 57 , , , cord-028721-x6f26ahr 4064 58 and and CC cord-028721-x6f26ahr 4064 59 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4064 60 's 's POS cord-028721-x6f26ahr 4064 61 syndrome syndrome NN cord-028721-x6f26ahr 4064 62 Über über NN cord-028721-x6f26ahr 4064 63 das das NNP cord-028721-x6f26ahr 4064 64 Verhalten Verhalten NNP cord-028721-x6f26ahr 4064 65 von von NNP cord-028721-x6f26ahr 4064 66 Hoden Hoden NNP cord-028721-x6f26ahr 4064 67 und und IN cord-028721-x6f26ahr 4064 68 Nebenhoden Nebenhoden NNP cord-028721-x6f26ahr 4064 69 bei bei NNP cord-028721-x6f26ahr 4064 70 angeborenem angeborenem NNP cord-028721-x6f26ahr 4064 71 Fehlen Fehlen NNP cord-028721-x6f26ahr 4064 72 des des FW cord-028721-x6f26ahr 4064 73 Ductus Ductus NNP cord-028721-x6f26ahr 4064 74 deferens deferen NNS cord-028721-x6f26ahr 4064 75 , , , cord-028721-x6f26ahr 4064 76 zugleich zugleich NNP cord-028721-x6f26ahr 4064 77 zur zur NNP cord-028721-x6f26ahr 4064 78 Frage Frage NNP cord-028721-x6f26ahr 4064 79 des des FW cord-028721-x6f26ahr 4064 80 Vorkommens Vorkommens NNP cord-028721-x6f26ahr 4064 81 von von NNP cord-028721-x6f26ahr 4064 82 Zwischenzellen Zwischenzellen NNP cord-028721-x6f26ahr 4064 83 in in IN cord-028721-x6f26ahr 4064 84 menschliche menschliche NNP cord-028721-x6f26ahr 4065 1 Nebenhoden Nebenhoden NNP cord-028721-x6f26ahr 4065 2 Sur Sur NNP cord-028721-x6f26ahr 4065 3 l'existence l'existence FW cord-028721-x6f26ahr 4065 4 de de NNP cord-028721-x6f26ahr 4065 5 glands glands NNP cord-028721-x6f26ahr 4065 6 sympathicotropes sympathicotropes NNP cord-028721-x6f26ahr 4065 7 dans dans NNP cord-028721-x6f26ahr 4065 8 l'ovaire l'ovaire NNP cord-028721-x6f26ahr 4065 9 et et NNP cord-028721-x6f26ahr 4065 10 le le NNP cord-028721-x6f26ahr 4065 11 testicule testicule NNP cord-028721-x6f26ahr 4065 12 humains humains NNPS cord-028721-x6f26ahr 4065 13 ; ; : cord-028721-x6f26ahr 4065 14 leur leur NNP cord-028721-x6f26ahr 4065 15 rapport rapport FW cord-028721-x6f26ahr 4065 16 avec avec FW cord-028721-x6f26ahr 4065 17 la la FW cord-028721-x6f26ahr 4065 18 glande glande NNP cord-028721-x6f26ahr 4065 19 interstitielle interstitielle NNP cord-028721-x6f26ahr 4065 20 du du NNP cord-028721-x6f26ahr 4065 21 testicule testicule NNP cord-028721-x6f26ahr 4065 22 Zur Zur NNP cord-028721-x6f26ahr 4065 23 Ultrastrusktur Ultrastrusktur NNP cord-028721-x6f26ahr 4066 1 der der NNP cord-028721-x6f26ahr 4066 2 Leydigzellen Leydigzellen NNP cord-028721-x6f26ahr 4067 1 i -PRON- PRP cord-028721-x6f26ahr 4067 2 m be VBP cord-028721-x6f26ahr 4067 3 Funiculus Funiculus NNP cord-028721-x6f26ahr 4067 4 spermaticus spermaticus NNP cord-028721-x6f26ahr 4067 5 des des FW cord-028721-x6f26ahr 4067 6 Menschen Menschen NNP cord-028721-x6f26ahr 4067 7 Histogenesis Histogenesis NNP cord-028721-x6f26ahr 4067 8 of of IN cord-028721-x6f26ahr 4067 9 human human JJ cord-028721-x6f26ahr 4067 10 extraparenchymal extraparenchymal NNP cord-028721-x6f26ahr 4068 1 Leydig leydig NN cord-028721-x6f26ahr 4068 2 cells cell NNS cord-028721-x6f26ahr 4069 1 Presentación Presentación NNP cord-028721-x6f26ahr 4069 2 de de NNP cord-028721-x6f26ahr 4069 3 un un NNP cord-028721-x6f26ahr 4069 4 caso caso NNP cord-028721-x6f26ahr 4069 5 y y NNP cord-028721-x6f26ahr 4069 6 revisión revisión NNP cord-028721-x6f26ahr 4069 7 de de NNP cord-028721-x6f26ahr 4069 8 la la NNP cord-028721-x6f26ahr 4069 9 literatura literatura NNP cord-028721-x6f26ahr 4069 10 Testicular Testicular NNP cord-028721-x6f26ahr 4069 11 lipomatosis lipomatosis NN cord-028721-x6f26ahr 4069 12 in in IN cord-028721-x6f26ahr 4069 13 Cowden Cowden NNP cord-028721-x6f26ahr 4069 14 's 's POS cord-028721-x6f26ahr 4069 15 syndrome syndrome NN cord-028721-x6f26ahr 4069 16 Age age NN cord-028721-x6f26ahr 4069 17 - - HYPH cord-028721-x6f26ahr 4069 18 related relate VBN cord-028721-x6f26ahr 4069 19 epididymis epididymis NN cord-028721-x6f26ahr 4069 20 - - HYPH cord-028721-x6f26ahr 4069 21 like like JJ cord-028721-x6f26ahr 4069 22 intratesticular intratesticular JJ cord-028721-x6f26ahr 4069 23 structures structure NNS cord-028721-x6f26ahr 4069 24 : : : cord-028721-x6f26ahr 4069 25 benign benign JJ cord-028721-x6f26ahr 4069 26 lesions lesion NNS cord-028721-x6f26ahr 4069 27 of of IN cord-028721-x6f26ahr 4069 28 Wolffi Wolffi NNP cord-028721-x6f26ahr 4069 29 an an DT cord-028721-x6f26ahr 4069 30 origin origin NN cord-028721-x6f26ahr 4069 31 that that WDT cord-028721-x6f26ahr 4069 32 can can MD cord-028721-x6f26ahr 4069 33 be be VB cord-028721-x6f26ahr 4069 34 misdiagnosed misdiagnose VBN cord-028721-x6f26ahr 4069 35 as as IN cord-028721-x6f26ahr 4069 36 testicular testicular JJ cord-028721-x6f26ahr 4069 37 tumors tumor NNS cord-028721-x6f26ahr 4069 38 Male male JJ cord-028721-x6f26ahr 4069 39 reproductive reproductive JJ cord-028721-x6f26ahr 4069 40 disorders disorder NNS cord-028721-x6f26ahr 4069 41 in in IN cord-028721-x6f26ahr 4069 42 humans human NNS cord-028721-x6f26ahr 4069 43 and and CC cord-028721-x6f26ahr 4069 44 prenatal prenatal JJ cord-028721-x6f26ahr 4069 45 indicators indicator NNS cord-028721-x6f26ahr 4069 46 of of IN cord-028721-x6f26ahr 4069 47 estrogen estrogen NN cord-028721-x6f26ahr 4069 48 exposure exposure NN cord-028721-x6f26ahr 4069 49 . . . cord-028721-x6f26ahr 4070 1 A a DT cord-028721-x6f26ahr 4070 2 review review NN cord-028721-x6f26ahr 4070 3 of of IN cord-028721-x6f26ahr 4070 4 published publish VBN cord-028721-x6f26ahr 4070 5 epidemiological epidemiological JJ cord-028721-x6f26ahr 4070 6 studies study NNS cord-028721-x6f26ahr 4070 7 Testicular testicular JJ cord-028721-x6f26ahr 4070 8 cancers cancer NNS cord-028721-x6f26ahr 4070 9 occurring occur VBG cord-028721-x6f26ahr 4070 10 in in IN cord-028721-x6f26ahr 4070 11 brothers brother NNS cord-028721-x6f26ahr 4070 12 with with IN cord-028721-x6f26ahr 4070 13 cryptorchism cryptorchism NN cord-028721-x6f26ahr 4070 14 Anatomical anatomical JJ cord-028721-x6f26ahr 4070 15 , , , cord-028721-x6f26ahr 4070 16 morphological morphological JJ cord-028721-x6f26ahr 4070 17 and and CC cord-028721-x6f26ahr 4070 18 volumetric volumetric JJ cord-028721-x6f26ahr 4070 19 analysis analysis NN cord-028721-x6f26ahr 4070 20 : : : cord-028721-x6f26ahr 4070 21 a a DT cord-028721-x6f26ahr 4070 22 review review NN cord-028721-x6f26ahr 4070 23 of of IN cord-028721-x6f26ahr 4070 24 759 759 CD cord-028721-x6f26ahr 4070 25 cases case NNS cord-028721-x6f26ahr 4070 26 of of IN cord-028721-x6f26ahr 4070 27 testicular testicular JJ cord-028721-x6f26ahr 4070 28 maldescent maldescent NNP cord-028721-x6f26ahr 4070 29 Risk Risk NNP cord-028721-x6f26ahr 4070 30 factor factor NN cord-028721-x6f26ahr 4070 31 patterns pattern NNS cord-028721-x6f26ahr 4070 32 for for IN cord-028721-x6f26ahr 4070 33 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4070 34 and and CC cord-028721-x6f26ahr 4070 35 hypospadias hypospadia NNS cord-028721-x6f26ahr 4070 36 Cryptorchidism Cryptorchidism NNP cord-028721-x6f26ahr 4070 37 : : : cord-028721-x6f26ahr 4070 38 a a DT cord-028721-x6f26ahr 4070 39 registry registry NN cord-028721-x6f26ahr 4070 40 based base VBN cord-028721-x6f26ahr 4070 41 study study NN cord-028721-x6f26ahr 4070 42 in in IN cord-028721-x6f26ahr 4070 43 Sweden Sweden NNP cord-028721-x6f26ahr 4070 44 on on IN cord-028721-x6f26ahr 4070 45 some some DT cord-028721-x6f26ahr 4070 46 factors factor NNS cord-028721-x6f26ahr 4070 47 of of IN cord-028721-x6f26ahr 4070 48 some some DT cord-028721-x6f26ahr 4070 49 possible possible JJ cord-028721-x6f26ahr 4070 50 etiological etiological JJ cord-028721-x6f26ahr 4070 51 importance importance NN cord-028721-x6f26ahr 4070 52 Maternal maternal JJ cord-028721-x6f26ahr 4070 53 and and CC cord-028721-x6f26ahr 4070 54 neonatal neonatal JJ cord-028721-x6f26ahr 4070 55 risk risk NN cord-028721-x6f26ahr 4070 56 factors factor NNS cord-028721-x6f26ahr 4070 57 for for IN cord-028721-x6f26ahr 4070 58 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4070 59 Risk risk NN cord-028721-x6f26ahr 4070 60 factors factor NNS cord-028721-x6f26ahr 4070 61 for for IN cord-028721-x6f26ahr 4070 62 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4070 63 and and CC cord-028721-x6f26ahr 4070 64 hypospadias hypospadia NNS cord-028721-x6f26ahr 4070 65 Abnormalities abnormality NNS cord-028721-x6f26ahr 4070 66 of of IN cord-028721-x6f26ahr 4070 67 testicular testicular JJ cord-028721-x6f26ahr 4070 68 descent descent NN cord-028721-x6f26ahr 4070 69 Surgical surgical JJ cord-028721-x6f26ahr 4070 70 outcome outcome NN cord-028721-x6f26ahr 4070 71 of of IN cord-028721-x6f26ahr 4070 72 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 4070 73 II II NNP cord-028721-x6f26ahr 4070 74 . . . cord-028721-x6f26ahr 4071 1 Trapped trapped JJ cord-028721-x6f26ahr 4071 2 and and CC cord-028721-x6f26ahr 4071 3 ascending ascend VBG cord-028721-x6f26ahr 4071 4 testes testis NNS cord-028721-x6f26ahr 4071 5 Iatrogenic iatrogenic JJ cord-028721-x6f26ahr 4071 6 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4071 7 resulting result VBG cord-028721-x6f26ahr 4071 8 from from IN cord-028721-x6f26ahr 4071 9 hernia hernia NN cord-028721-x6f26ahr 4071 10 repair repair NN cord-028721-x6f26ahr 4071 11 Iatrogenic iatrogenic JJ cord-028721-x6f26ahr 4071 12 ascent ascent NN cord-028721-x6f26ahr 4071 13 of of IN cord-028721-x6f26ahr 4071 14 the the DT cord-028721-x6f26ahr 4071 15 testis testis NN cord-028721-x6f26ahr 4071 16 : : : cord-028721-x6f26ahr 4071 17 an an DT cord-028721-x6f26ahr 4071 18 under under RB cord-028721-x6f26ahr 4071 19 - - HYPH cord-028721-x6f26ahr 4071 20 recognized recognize VBN cord-028721-x6f26ahr 4071 21 complication complication NN cord-028721-x6f26ahr 4071 22 of of IN cord-028721-x6f26ahr 4071 23 inguinal inguinal JJ cord-028721-x6f26ahr 4071 24 hernia hernia NN cord-028721-x6f26ahr 4071 25 operation operation NN cord-028721-x6f26ahr 4071 26 in in IN cord-028721-x6f26ahr 4071 27 children child NNS cord-028721-x6f26ahr 4071 28 Iatrogenic iatrogenic JJ cord-028721-x6f26ahr 4071 29 ascent ascent NN cord-028721-x6f26ahr 4071 30 of of IN cord-028721-x6f26ahr 4071 31 the the DT cord-028721-x6f26ahr 4071 32 testis testis NN cord-028721-x6f26ahr 4071 33 : : : cord-028721-x6f26ahr 4071 34 an an DT cord-028721-x6f26ahr 4071 35 underrecognized underrecognized JJ cord-028721-x6f26ahr 4071 36 complication complication NN cord-028721-x6f26ahr 4071 37 of of IN cord-028721-x6f26ahr 4071 38 inguinal inguinal JJ cord-028721-x6f26ahr 4071 39 hernia hernia NN cord-028721-x6f26ahr 4071 40 operation operation NN cord-028721-x6f26ahr 4071 41 in in IN cord-028721-x6f26ahr 4071 42 children child NNS cord-028721-x6f26ahr 4071 43 Testicular Testicular NNP cord-028721-x6f26ahr 4071 44 descent descent NN cord-028721-x6f26ahr 4071 45 and and CC cord-028721-x6f26ahr 4071 46 ascent ascent NN cord-028721-x6f26ahr 4071 47 in in IN cord-028721-x6f26ahr 4071 48 the the DT cord-028721-x6f26ahr 4071 49 fi fi NNP cord-028721-x6f26ahr 4071 50 rst rst NN cord-028721-x6f26ahr 4071 51 year year NN cord-028721-x6f26ahr 4071 52 of of IN cord-028721-x6f26ahr 4071 53 life life NN cord-028721-x6f26ahr 4072 1 Late late JJ cord-028721-x6f26ahr 4072 2 presentation presentation NN cord-028721-x6f26ahr 4072 3 of of IN cord-028721-x6f26ahr 4072 4 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4072 5 : : : cord-028721-x6f26ahr 4072 6 The the DT cord-028721-x6f26ahr 4072 7 etiology etiology NN cord-028721-x6f26ahr 4072 8 of of IN cord-028721-x6f26ahr 4072 9 testicular testicular NN cord-028721-x6f26ahr 4072 10 re re NN cord-028721-x6f26ahr 4072 11 - - NN cord-028721-x6f26ahr 4072 12 ascent ascent JJ cord-028721-x6f26ahr 4072 13 Ascent Ascent NNP cord-028721-x6f26ahr 4072 14 of of IN cord-028721-x6f26ahr 4072 15 the the DT cord-028721-x6f26ahr 4072 16 testis testis NN cord-028721-x6f26ahr 4072 17 : : : cord-028721-x6f26ahr 4072 18 fact fact NN cord-028721-x6f26ahr 4072 19 or or CC cord-028721-x6f26ahr 4072 20 fi fi NN cord-028721-x6f26ahr 4072 21 ction ction NN cord-028721-x6f26ahr 4072 22 Incomplete incomplete JJ cord-028721-x6f26ahr 4072 23 disappearance disappearance NN cord-028721-x6f26ahr 4072 24 of of IN cord-028721-x6f26ahr 4072 25 the the DT cord-028721-x6f26ahr 4072 26 processus processus NNP cord-028721-x6f26ahr 4072 27 vaginalis vaginalis NNP cord-028721-x6f26ahr 4072 28 as as IN cord-028721-x6f26ahr 4072 29 a a DT cord-028721-x6f26ahr 4072 30 cause cause NN cord-028721-x6f26ahr 4072 31 of of IN cord-028721-x6f26ahr 4072 32 ascending ascend VBG cord-028721-x6f26ahr 4072 33 testis testis NN cord-028721-x6f26ahr 4072 34 Undescended undescended JJ cord-028721-x6f26ahr 4072 35 testis testis NN cord-028721-x6f26ahr 4072 36 : : : cord-028721-x6f26ahr 4072 37 congenital congenital JJ cord-028721-x6f26ahr 4072 38 or or CC cord-028721-x6f26ahr 4072 39 acquired acquire VBN cord-028721-x6f26ahr 4072 40 ? ? . cord-028721-x6f26ahr 4073 1 Spontaneous spontaneous JJ cord-028721-x6f26ahr 4073 2 ascent ascent NN cord-028721-x6f26ahr 4073 3 of of IN cord-028721-x6f26ahr 4073 4 the the DT cord-028721-x6f26ahr 4073 5 testis testis NN cord-028721-x6f26ahr 4073 6 Acquired acquire VBN cord-028721-x6f26ahr 4073 7 undescended undescended JJ cord-028721-x6f26ahr 4073 8 testis testis NN cord-028721-x6f26ahr 4073 9 Does do VBZ cord-028721-x6f26ahr 4073 10 proximal proximal JJ cord-028721-x6f26ahr 4073 11 genitofemoral genitofemoral JJ cord-028721-x6f26ahr 4073 12 nerve nerve NN cord-028721-x6f26ahr 4073 13 division division NN cord-028721-x6f26ahr 4073 14 induce induce VBP cord-028721-x6f26ahr 4073 15 testicular testicular JJ cord-028721-x6f26ahr 4073 16 maldescent maldescent NN cord-028721-x6f26ahr 4073 17 or or CC cord-028721-x6f26ahr 4073 18 ascent ascent JJ cord-028721-x6f26ahr 4073 19 in in IN cord-028721-x6f26ahr 4073 20 the the DT cord-028721-x6f26ahr 4073 21 rat rat NN cord-028721-x6f26ahr 4073 22 ? ? . cord-028721-x6f26ahr 4074 1 Association Association NNP cord-028721-x6f26ahr 4074 2 between between IN cord-028721-x6f26ahr 4074 3 testicular testicular NNP cord-028721-x6f26ahr 4074 4 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4074 5 , , , cord-028721-x6f26ahr 4074 6 testicular testicular JJ cord-028721-x6f26ahr 4074 7 cancer cancer NN cord-028721-x6f26ahr 4074 8 , , , cord-028721-x6f26ahr 4074 9 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4074 10 and and CC cord-028721-x6f26ahr 4074 11 history history NN cord-028721-x6f26ahr 4074 12 of of IN cord-028721-x6f26ahr 4074 13 ascending ascend VBG cord-028721-x6f26ahr 4074 14 testis testis NN cord-028721-x6f26ahr 4074 15 The the DT cord-028721-x6f26ahr 4074 16 ascending ascend VBG cord-028721-x6f26ahr 4074 17 testis testis NN cord-028721-x6f26ahr 4074 18 and and CC cord-028721-x6f26ahr 4074 19 the the DT cord-028721-x6f26ahr 4074 20 testis testis NN cord-028721-x6f26ahr 4074 21 undescended undescended JJ cord-028721-x6f26ahr 4074 22 since since IN cord-028721-x6f26ahr 4074 23 birth birth NN cord-028721-x6f26ahr 4074 24 share share VBP cord-028721-x6f26ahr 4074 25 the the DT cord-028721-x6f26ahr 4074 26 same same JJ cord-028721-x6f26ahr 4074 27 histopathology histopathology NN cord-028721-x6f26ahr 4074 28 Elevated elevated JJ cord-028721-x6f26ahr 4074 29 placental placental NN cord-028721-x6f26ahr 4074 30 estradiol estradiol NN cord-028721-x6f26ahr 4074 31 : : : cord-028721-x6f26ahr 4074 32 a a DT cord-028721-x6f26ahr 4074 33 possible possible JJ cord-028721-x6f26ahr 4074 34 etiological etiological JJ cord-028721-x6f26ahr 4074 35 factor factor NN cord-028721-x6f26ahr 4074 36 of of IN cord-028721-x6f26ahr 4074 37 human human JJ cord-028721-x6f26ahr 4074 38 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4075 1 Histologic Histologic NNP cord-028721-x6f26ahr 4075 2 observations observation NNS cord-028721-x6f26ahr 4075 3 in in IN cord-028721-x6f26ahr 4075 4 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4075 5 : : : cord-028721-x6f26ahr 4075 6 the the DT cord-028721-x6f26ahr 4075 7 congenital congenital JJ cord-028721-x6f26ahr 4075 8 germinal germinal JJ cord-028721-x6f26ahr 4075 9 - - HYPH cord-028721-x6f26ahr 4075 10 cell cell NN cord-028721-x6f26ahr 4075 11 defi defi NN cord-028721-x6f26ahr 4075 12 ciency ciency NN cord-028721-x6f26ahr 4075 13 of of IN cord-028721-x6f26ahr 4075 14 the the DT cord-028721-x6f26ahr 4075 15 undescended undescended JJ cord-028721-x6f26ahr 4075 16 testis testis NN cord-028721-x6f26ahr 4075 17 Histologic Histologic NNP cord-028721-x6f26ahr 4075 18 classifi classifi NN cord-028721-x6f26ahr 4075 19 cation cation NN cord-028721-x6f26ahr 4075 20 of of IN cord-028721-x6f26ahr 4075 21 undescended undescended JJ cord-028721-x6f26ahr 4075 22 testes testis NNS cord-028721-x6f26ahr 4075 23 Cytophotometric Cytophotometric NNP cord-028721-x6f26ahr 4075 24 DNA DNA NNP cord-028721-x6f26ahr 4075 25 quantifi quantifi NN cord-028721-x6f26ahr 4075 26 cation cation NN cord-028721-x6f26ahr 4075 27 in in IN cord-028721-x6f26ahr 4075 28 human human JJ cord-028721-x6f26ahr 4075 29 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 4075 30 of of IN cord-028721-x6f26ahr 4075 31 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4075 32 testes testis NNS cord-028721-x6f26ahr 4075 33 Early early JJ cord-028721-x6f26ahr 4075 34 postnatal postnatal JJ cord-028721-x6f26ahr 4075 35 testicular testicular JJ cord-028721-x6f26ahr 4075 36 maldevelopment maldevelopment NN cord-028721-x6f26ahr 4075 37 in in IN cord-028721-x6f26ahr 4075 38 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4075 39 Hormonal hormonal JJ cord-028721-x6f26ahr 4075 40 treatment treatment NN cord-028721-x6f26ahr 4075 41 of of IN cord-028721-x6f26ahr 4075 42 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4075 43 -hCG -hCG . cord-028721-x6f26ahr 4075 44 or or CC cord-028721-x6f26ahr 4075 45 GnRH GnRH NNP cord-028721-x6f26ahr 4075 46 -a -a HYPH cord-028721-x6f26ahr 4075 47 multicentre multicentre NNP cord-028721-x6f26ahr 4075 48 study study NN cord-028721-x6f26ahr 4075 49 Busereline busereline JJ cord-028721-x6f26ahr 4075 50 treatment treatment NN cord-028721-x6f26ahr 4075 51 of of IN cord-028721-x6f26ahr 4075 52 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4075 53 : : : cord-028721-x6f26ahr 4075 54 a a DT cord-028721-x6f26ahr 4075 55 randomized randomized JJ cord-028721-x6f26ahr 4075 56 , , , cord-028721-x6f26ahr 4075 57 double double JJ cord-028721-x6f26ahr 4075 58 - - HYPH cord-028721-x6f26ahr 4075 59 blind blind JJ cord-028721-x6f26ahr 4075 60 , , , cord-028721-x6f26ahr 4075 61 placebo placebo NN cord-028721-x6f26ahr 4075 62 - - HYPH cord-028721-x6f26ahr 4075 63 controlled control VBN cord-028721-x6f26ahr 4075 64 study study NN cord-028721-x6f26ahr 4075 65 Abnormal abnormal JJ cord-028721-x6f26ahr 4075 66 germ germ NN cord-028721-x6f26ahr 4075 67 cell cell NN cord-028721-x6f26ahr 4075 68 development development NN cord-028721-x6f26ahr 4075 69 in in IN cord-028721-x6f26ahr 4075 70 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4076 1 Anatomical anatomical JJ cord-028721-x6f26ahr 4076 2 , , , cord-028721-x6f26ahr 4076 3 morphological morphological JJ cord-028721-x6f26ahr 4076 4 and and CC cord-028721-x6f26ahr 4076 5 volumetric volumetric JJ cord-028721-x6f26ahr 4076 6 analysis analysis NN cord-028721-x6f26ahr 4076 7 : : : cord-028721-x6f26ahr 4076 8 A a DT cord-028721-x6f26ahr 4076 9 review review NN cord-028721-x6f26ahr 4076 10 of of IN cord-028721-x6f26ahr 4076 11 759 759 CD cord-028721-x6f26ahr 4076 12 cases case NNS cord-028721-x6f26ahr 4076 13 of of IN cord-028721-x6f26ahr 4076 14 testicular testicular JJ cord-028721-x6f26ahr 4076 15 maldescent maldescent NNP cord-028721-x6f26ahr 4076 16 Impact Impact NNP cord-028721-x6f26ahr 4076 17 of of IN cord-028721-x6f26ahr 4076 18 early early JJ cord-028721-x6f26ahr 4076 19 orchidopexy orchidopexy NN cord-028721-x6f26ahr 4076 20 on on IN cord-028721-x6f26ahr 4076 21 testicular testicular JJ cord-028721-x6f26ahr 4076 22 growth growth NN cord-028721-x6f26ahr 4077 1 Effi Effi NNP cord-028721-x6f26ahr 4077 2 cacy cacy NN cord-028721-x6f26ahr 4077 3 of of IN cord-028721-x6f26ahr 4077 4 orchiopexy orchiopexy NNP cord-028721-x6f26ahr 4077 5 by by IN cord-028721-x6f26ahr 4077 6 patient patient JJ cord-028721-x6f26ahr 4077 7 age age NN cord-028721-x6f26ahr 4078 1 1 1 CD cord-028721-x6f26ahr 4078 2 year year NN cord-028721-x6f26ahr 4078 3 for for IN cord-028721-x6f26ahr 4078 4 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4079 1 Clinical clinical JJ cord-028721-x6f26ahr 4079 2 and and CC cord-028721-x6f26ahr 4079 3 histopathologic histopathologic JJ cord-028721-x6f26ahr 4079 4 evaluation evaluation NN cord-028721-x6f26ahr 4079 5 of of IN cord-028721-x6f26ahr 4079 6 operated operate VBN cord-028721-x6f26ahr 4079 7 maldescended maldescended JJ cord-028721-x6f26ahr 4079 8 testes testis NNS cord-028721-x6f26ahr 4079 9 after after IN cord-028721-x6f26ahr 4079 10 luteinizing luteinize VBG cord-028721-x6f26ahr 4079 11 hormonereleasing hormonerelease VBG cord-028721-x6f26ahr 4079 12 hormone hormone NN cord-028721-x6f26ahr 4079 13 treatment treatment NN cord-028721-x6f26ahr 4080 1 Bilateral bilateral JJ cord-028721-x6f26ahr 4080 2 prepubertad prepubertad JJ cord-028721-x6f26ahr 4080 3 testicular testicular NNP cord-028721-x6f26ahr 4080 4 biopsias biopsia NNS cord-028721-x6f26ahr 4080 5 predict predict VBP cord-028721-x6f26ahr 4080 6 signifi signifi NNP cord-028721-x6f26ahr 4080 7 cance cance NN cord-028721-x6f26ahr 4080 8 of of IN cord-028721-x6f26ahr 4080 9 cryptorchisism cryptorchisism NN cord-028721-x6f26ahr 4080 10 - - HYPH cord-028721-x6f26ahr 4080 11 associated associate VBN cord-028721-x6f26ahr 4080 12 mixed mixed JJ cord-028721-x6f26ahr 4080 13 testicular testicular JJ cord-028721-x6f26ahr 4080 14 atrophy atrophy NN cord-028721-x6f26ahr 4080 15 , , , cord-028721-x6f26ahr 4080 16 and and CC cord-028721-x6f26ahr 4080 17 allow allow VB cord-028721-x6f26ahr 4080 18 assessment assessment NN cord-028721-x6f26ahr 4080 19 of of IN cord-028721-x6f26ahr 4080 20 fertility fertility NN cord-028721-x6f26ahr 4080 21 Multinucleated multinucleate VBN cord-028721-x6f26ahr 4080 22 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 4080 23 in in IN cord-028721-x6f26ahr 4080 24 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4080 25 boys boy NNS cord-028721-x6f26ahr 4080 26 : : : cord-028721-x6f26ahr 4080 27 a a DT cord-028721-x6f26ahr 4080 28 possible possible JJ cord-028721-x6f26ahr 4080 29 association association NN cord-028721-x6f26ahr 4080 30 with with IN cord-028721-x6f26ahr 4080 31 an an DT cord-028721-x6f26ahr 4080 32 increased increase VBN cord-028721-x6f26ahr 4080 33 risk risk NN cord-028721-x6f26ahr 4080 34 of of IN cord-028721-x6f26ahr 4080 35 testicular testicular JJ cord-028721-x6f26ahr 4080 36 malignancy malignancy NN cord-028721-x6f26ahr 4080 37 Y Y NNP cord-028721-x6f26ahr 4080 38 chromosome chromosome NN cord-028721-x6f26ahr 4080 39 microdeletions microdeletion NNS cord-028721-x6f26ahr 4080 40 in in IN cord-028721-x6f26ahr 4080 41 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4080 42 and and CC cord-028721-x6f26ahr 4080 43 idiopathic idiopathic JJ cord-028721-x6f26ahr 4080 44 infertility infertility NN cord-028721-x6f26ahr 4081 1 An an DT cord-028721-x6f26ahr 4081 2 unusual unusual JJ cord-028721-x6f26ahr 4081 3 subset subset NN cord-028721-x6f26ahr 4081 4 of of IN cord-028721-x6f26ahr 4081 5 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4081 6 : : : cord-028721-x6f26ahr 4081 7 possible possible JJ cord-028721-x6f26ahr 4081 8 end end NN cord-028721-x6f26ahr 4081 9 organ organ NN cord-028721-x6f26ahr 4081 10 failure failure NN cord-028721-x6f26ahr 4081 11 Ascent Ascent NNP cord-028721-x6f26ahr 4081 12 of of IN cord-028721-x6f26ahr 4081 13 the the DT cord-028721-x6f26ahr 4081 14 testis testis NN cord-028721-x6f26ahr 4081 15 in in IN cord-028721-x6f26ahr 4081 16 children child NNS cord-028721-x6f26ahr 4082 1 Impaired impaired JJ cord-028721-x6f26ahr 4082 2 germ germ NN cord-028721-x6f26ahr 4082 3 cells cell NNS cord-028721-x6f26ahr 4082 4 in in IN cord-028721-x6f26ahr 4082 5 secondary secondary JJ cord-028721-x6f26ahr 4082 6 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4082 7 testis testis NN cord-028721-x6f26ahr 4082 8 after after IN cord-028721-x6f26ahr 4082 9 herniotomy herniotomy NN cord-028721-x6f26ahr 4082 10 Elastic elastic JJ cord-028721-x6f26ahr 4082 11 fi fi NNP cord-028721-x6f26ahr 4082 12 bers ber NNS cord-028721-x6f26ahr 4082 13 in in IN cord-028721-x6f26ahr 4082 14 tunica tunica NNP cord-028721-x6f26ahr 4082 15 propria propria FW cord-028721-x6f26ahr 4082 16 of of IN cord-028721-x6f26ahr 4082 17 undescended undescended JJ cord-028721-x6f26ahr 4082 18 and and CC cord-028721-x6f26ahr 4082 19 contralateral contralateral JJ cord-028721-x6f26ahr 4082 20 scrotal scrotal JJ cord-028721-x6f26ahr 4082 21 testes testis NNS cord-028721-x6f26ahr 4082 22 from from IN cord-028721-x6f26ahr 4082 23 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4082 24 patients patient NNS cord-028721-x6f26ahr 4082 25 Hyperplasia hyperplasia NN cord-028721-x6f26ahr 4082 26 and and CC cord-028721-x6f26ahr 4082 27 the the DT cord-028721-x6f26ahr 4082 28 immature immature JJ cord-028721-x6f26ahr 4082 29 appearance appearance NN cord-028721-x6f26ahr 4082 30 of of IN cord-028721-x6f26ahr 4082 31 Sertoli Sertoli NNP cord-028721-x6f26ahr 4082 32 cells cell NNS cord-028721-x6f26ahr 4082 33 in in IN cord-028721-x6f26ahr 4082 34 primary primary JJ cord-028721-x6f26ahr 4082 35 testicular testicular JJ cord-028721-x6f26ahr 4082 36 disorders disorder NNS cord-028721-x6f26ahr 4082 37 Focal focal JJ cord-028721-x6f26ahr 4082 38 orchitis orchitis NN cord-028721-x6f26ahr 4082 39 in in IN cord-028721-x6f26ahr 4082 40 undescended undescended JJ cord-028721-x6f26ahr 4082 41 testes testis NNS cord-028721-x6f26ahr 4082 42 : : : cord-028721-x6f26ahr 4082 43 discussion discussion NN cord-028721-x6f26ahr 4082 44 of of IN cord-028721-x6f26ahr 4082 45 pathogenetic pathogenetic JJ cord-028721-x6f26ahr 4082 46 mechanisms mechanism NNS cord-028721-x6f26ahr 4082 47 of of IN cord-028721-x6f26ahr 4082 48 tubular tubular JJ cord-028721-x6f26ahr 4082 49 atrophy atrophy NN cord-028721-x6f26ahr 4082 50 Undescended undescended JJ cord-028721-x6f26ahr 4082 51 testes testis NNS cord-028721-x6f26ahr 4082 52 in in IN cord-028721-x6f26ahr 4082 53 adults adult NNS cord-028721-x6f26ahr 4082 54 : : : cord-028721-x6f26ahr 4083 1 clinical clinical JJ cord-028721-x6f26ahr 4083 2 signifi signifi NNP cord-028721-x6f26ahr 4083 3 cance cance NN cord-028721-x6f26ahr 4083 4 of of IN cord-028721-x6f26ahr 4083 5 resistive resistive JJ cord-028721-x6f26ahr 4083 6 index index NN cord-028721-x6f26ahr 4083 7 values value NNS cord-028721-x6f26ahr 4083 8 of of IN cord-028721-x6f26ahr 4083 9 the the DT cord-028721-x6f26ahr 4083 10 testicular testicular JJ cord-028721-x6f26ahr 4083 11 artery artery NN cord-028721-x6f26ahr 4083 12 measured measure VBN cord-028721-x6f26ahr 4083 13 by by IN cord-028721-x6f26ahr 4083 14 Doppler Doppler NNP cord-028721-x6f26ahr 4083 15 ultrasound ultrasound NN cord-028721-x6f26ahr 4083 16 as as IN cord-028721-x6f26ahr 4083 17 a a DT cord-028721-x6f26ahr 4083 18 predictor predictor NN cord-028721-x6f26ahr 4083 19 of of IN cord-028721-x6f26ahr 4083 20 testicular testicular JJ cord-028721-x6f26ahr 4083 21 histology histology NN cord-028721-x6f26ahr 4083 22 Testicular Testicular NNP cord-028721-x6f26ahr 4083 23 function function NN cord-028721-x6f26ahr 4083 24 in in IN cord-028721-x6f26ahr 4083 25 men man NNS cord-028721-x6f26ahr 4083 26 treated treat VBN cord-028721-x6f26ahr 4083 27 in in IN cord-028721-x6f26ahr 4083 28 childhood childhood NN cord-028721-x6f26ahr 4083 29 for for IN cord-028721-x6f26ahr 4083 30 undescended undescended JJ cord-028721-x6f26ahr 4083 31 testes testis NNS cord-028721-x6f26ahr 4083 32 Histologic Histologic NNP cord-028721-x6f26ahr 4083 33 lesions lesion NNS cord-028721-x6f26ahr 4083 34 in in IN cord-028721-x6f26ahr 4083 35 undescended undescended JJ cord-028721-x6f26ahr 4083 36 ectopic ectopic JJ cord-028721-x6f26ahr 4083 37 obstructed obstruct VBN cord-028721-x6f26ahr 4083 38 testes testis NNS cord-028721-x6f26ahr 4083 39 Is be VBZ cord-028721-x6f26ahr 4083 40 a a DT cord-028721-x6f26ahr 4083 41 testis testis NN cord-028721-x6f26ahr 4083 42 located locate VBN cord-028721-x6f26ahr 4083 43 at at IN cord-028721-x6f26ahr 4083 44 the the DT cord-028721-x6f26ahr 4083 45 superfi superfi NNP cord-028721-x6f26ahr 4083 46 cial cial NNP cord-028721-x6f26ahr 4083 47 inguinal inguinal JJ cord-028721-x6f26ahr 4083 48 pouch pouch NN cord-028721-x6f26ahr 4083 49 ( ( -LRB- cord-028721-x6f26ahr 4083 50 Denis Denis NNP cord-028721-x6f26ahr 4083 51 Browne Browne NNP cord-028721-x6f26ahr 4083 52 pouch pouch NN cord-028721-x6f26ahr 4083 53 ) ) -RRB- cord-028721-x6f26ahr 4083 54 comparable comparable JJ cord-028721-x6f26ahr 4083 55 to to IN cord-028721-x6f26ahr 4083 56 a a DT cord-028721-x6f26ahr 4083 57 true true JJ cord-028721-x6f26ahr 4083 58 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4083 59 testis testis NN cord-028721-x6f26ahr 4083 60 ? ? . cord-028721-x6f26ahr 4084 1 Histologic Histologic NNP cord-028721-x6f26ahr 4084 2 maldevelopment maldevelopment NN cord-028721-x6f26ahr 4084 3 of of IN cord-028721-x6f26ahr 4084 4 unilaterally unilaterally RB cord-028721-x6f26ahr 4084 5 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4084 6 testes testis NNS cord-028721-x6f26ahr 4084 7 and and CC cord-028721-x6f26ahr 4084 8 their -PRON- PRP$ cord-028721-x6f26ahr 4084 9 descended descend VBN cord-028721-x6f26ahr 4084 10 partners partner NNS cord-028721-x6f26ahr 4084 11 Anatomical anatomical JJ cord-028721-x6f26ahr 4084 12 , , , cord-028721-x6f26ahr 4084 13 morphological morphological JJ cord-028721-x6f26ahr 4084 14 and and CC cord-028721-x6f26ahr 4084 15 volumetric volumetric JJ cord-028721-x6f26ahr 4084 16 analysis analysis NN cord-028721-x6f26ahr 4084 17 : : : cord-028721-x6f26ahr 4084 18 a a DT cord-028721-x6f26ahr 4084 19 review review NN cord-028721-x6f26ahr 4084 20 of of IN cord-028721-x6f26ahr 4084 21 759 759 CD cord-028721-x6f26ahr 4084 22 cases case NNS cord-028721-x6f26ahr 4084 23 of of IN cord-028721-x6f26ahr 4084 24 testicular testicular JJ cord-028721-x6f26ahr 4084 25 maldescent maldescent NN cord-028721-x6f26ahr 4084 26 Les Les NNP cord-028721-x6f26ahr 4084 27 testicules testicules FW cord-028721-x6f26ahr 4084 28 oscillants oscillant NNS cord-028721-x6f26ahr 4084 29 . . . cord-028721-x6f26ahr 4085 1 forme forme NNP cord-028721-x6f26ahr 4085 2 degradée degradée NNP cord-028721-x6f26ahr 4085 3 de de IN cord-028721-x6f26ahr 4085 4 cryptorchidie cryptorchidie NNP cord-028721-x6f26ahr 4085 5 ? ? . cord-028721-x6f26ahr 4086 1 Infertility infertility NN cord-028721-x6f26ahr 4086 2 in in IN cord-028721-x6f26ahr 4086 3 adult adult NN cord-028721-x6f26ahr 4086 4 males male NNS cord-028721-x6f26ahr 4086 5 with with IN cord-028721-x6f26ahr 4086 6 retractile retractile JJ cord-028721-x6f26ahr 4086 7 testes testis NNS cord-028721-x6f26ahr 4086 8 Changes change NNS cord-028721-x6f26ahr 4086 9 in in IN cord-028721-x6f26ahr 4086 10 the the DT cord-028721-x6f26ahr 4086 11 volume volume NN cord-028721-x6f26ahr 4086 12 and and CC cord-028721-x6f26ahr 4086 13 histology histology NN cord-028721-x6f26ahr 4086 14 of of IN cord-028721-x6f26ahr 4086 15 retractile retractile JJ cord-028721-x6f26ahr 4086 16 testes testis NNS cord-028721-x6f26ahr 4086 17 in in IN cord-028721-x6f26ahr 4086 18 prepubertal prepubertal JJ cord-028721-x6f26ahr 4086 19 boys boy NNS cord-028721-x6f26ahr 4087 1 The the DT cord-028721-x6f26ahr 4087 2 retractile retractile JJ cord-028721-x6f26ahr 4087 3 testis testis NN cord-028721-x6f26ahr 4087 4 Retractile Retractile NNP cord-028721-x6f26ahr 4087 5 testis testis NN cord-028721-x6f26ahr 4088 1 -is -is . cord-028721-x6f26ahr 4089 1 it -PRON- PRP cord-028721-x6f26ahr 4089 2 really really RB cord-028721-x6f26ahr 4089 3 a a DT cord-028721-x6f26ahr 4089 4 normal normal JJ cord-028721-x6f26ahr 4089 5 variant variant NN cord-028721-x6f26ahr 4089 6 ? ? . cord-028721-x6f26ahr 4090 1 Bilateral bilateral JJ cord-028721-x6f26ahr 4090 2 retractile retractile JJ cord-028721-x6f26ahr 4090 3 testes testis NNS cord-028721-x6f26ahr 4091 1 -subsequent -subsequent . cord-028721-x6f26ahr 4092 1 effects effect NNS cord-028721-x6f26ahr 4092 2 on on IN cord-028721-x6f26ahr 4092 3 fertility fertility NN cord-028721-x6f26ahr 4092 4 Effect effect NN cord-028721-x6f26ahr 4092 5 of of IN cord-028721-x6f26ahr 4092 6 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4092 7 and and CC cord-028721-x6f26ahr 4092 8 retractile retractile JJ cord-028721-x6f26ahr 4092 9 testes testis NNS cord-028721-x6f26ahr 4092 10 on on IN cord-028721-x6f26ahr 4092 11 male male JJ cord-028721-x6f26ahr 4092 12 factor factor NN cord-028721-x6f26ahr 4092 13 infertility infertility NN cord-028721-x6f26ahr 4093 1 : : : cord-028721-x6f26ahr 4093 2 a a DT cord-028721-x6f26ahr 4093 3 multicenter multicenter JJ cord-028721-x6f26ahr 4093 4 , , , cord-028721-x6f26ahr 4093 5 retrospective retrospective JJ cord-028721-x6f26ahr 4093 6 , , , cord-028721-x6f26ahr 4093 7 chart chart NN cord-028721-x6f26ahr 4093 8 review review NN cord-028721-x6f26ahr 4093 9 Epididymal Epididymal NNP cord-028721-x6f26ahr 4093 10 anomalies anomaly NNS cord-028721-x6f26ahr 4093 11 associated associate VBN cord-028721-x6f26ahr 4093 12 with with IN cord-028721-x6f26ahr 4093 13 hydrocele hydrocele NN cord-028721-x6f26ahr 4093 14 / / SYM cord-028721-x6f26ahr 4093 15 hernia hernia NN cord-028721-x6f26ahr 4093 16 and and CC cord-028721-x6f26ahr 4093 17 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4093 18 : : : cord-028721-x6f26ahr 4093 19 implications implication NNS cord-028721-x6f26ahr 4093 20 regarding regard VBG cord-028721-x6f26ahr 4093 21 testicular testicular JJ cord-028721-x6f26ahr 4093 22 descent descent NN cord-028721-x6f26ahr 4093 23 Congenital congenital JJ cord-028721-x6f26ahr 4093 24 deformities deformity NNS cord-028721-x6f26ahr 4093 25 of of IN cord-028721-x6f26ahr 4093 26 the the DT cord-028721-x6f26ahr 4093 27 testis testis NN cord-028721-x6f26ahr 4093 28 and and CC cord-028721-x6f26ahr 4093 29 epididymis epididymis NN cord-028721-x6f26ahr 4093 30 Signifi Signifi NNP cord-028721-x6f26ahr 4093 31 cance cance NN cord-028721-x6f26ahr 4093 32 of of IN cord-028721-x6f26ahr 4093 33 epididymal epididymal JJ cord-028721-x6f26ahr 4093 34 and and CC cord-028721-x6f26ahr 4093 35 ductal ductal JJ cord-028721-x6f26ahr 4093 36 anomalies anomaly NNS cord-028721-x6f26ahr 4093 37 associated associate VBN cord-028721-x6f26ahr 4093 38 with with IN cord-028721-x6f26ahr 4093 39 undescended undescended JJ cord-028721-x6f26ahr 4093 40 testis testis NN cord-028721-x6f26ahr 4093 41 Insulin insulin NN cord-028721-x6f26ahr 4093 42 - - HYPH cord-028721-x6f26ahr 4093 43 like like JJ cord-028721-x6f26ahr 4093 44 factor factor NN cord-028721-x6f26ahr 4093 45 3 3 CD cord-028721-x6f26ahr 4093 46 gene gene NN cord-028721-x6f26ahr 4093 47 mutations mutation NNS cord-028721-x6f26ahr 4093 48 in in IN cord-028721-x6f26ahr 4093 49 testicular testicular NNP cord-028721-x6f26ahr 4093 50 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 4093 51 syndrome syndrome NN cord-028721-x6f26ahr 4093 52 : : : cord-028721-x6f26ahr 4093 53 clinical clinical JJ cord-028721-x6f26ahr 4093 54 and and CC cord-028721-x6f26ahr 4093 55 functional functional JJ cord-028721-x6f26ahr 4093 56 characterization characterization NN cord-028721-x6f26ahr 4093 57 Testicular Testicular NNP cord-028721-x6f26ahr 4093 58 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4093 59 syndrome syndrome NN cord-028721-x6f26ahr 4093 60 : : : cord-028721-x6f26ahr 4093 61 possible possible JJ cord-028721-x6f26ahr 4093 62 role role NN cord-028721-x6f26ahr 4093 63 of of IN cord-028721-x6f26ahr 4093 64 endocrine endocrine JJ cord-028721-x6f26ahr 4093 65 disrupters disrupter NNS cord-028721-x6f26ahr 4093 66 Ethnic ethnic JJ cord-028721-x6f26ahr 4093 67 differences difference NNS cord-028721-x6f26ahr 4093 68 in in IN cord-028721-x6f26ahr 4093 69 occurrence occurrence NN cord-028721-x6f26ahr 4093 70 of of IN cord-028721-x6f26ahr 4093 71 TDS TDS NNP cord-028721-x6f26ahr 4093 72 -genetics -genetic NNS cord-028721-x6f26ahr 4093 73 and/or and/or CC cord-028721-x6f26ahr 4093 74 environment environment NN cord-028721-x6f26ahr 4093 75 ? ? . cord-028721-x6f26ahr 4094 1 Granular granular JJ cord-028721-x6f26ahr 4094 2 changes change NNS cord-028721-x6f26ahr 4094 3 in in IN cord-028721-x6f26ahr 4094 4 Sertoli Sertoli NNP cord-028721-x6f26ahr 4094 5 cells cell NNS cord-028721-x6f26ahr 4094 6 in in IN cord-028721-x6f26ahr 4094 7 children child NNS cord-028721-x6f26ahr 4094 8 and and CC cord-028721-x6f26ahr 4094 9 pubertal pubertal JJ cord-028721-x6f26ahr 4094 10 patients patient NNS cord-028721-x6f26ahr 4095 1 Erythropoietin erythropoietin NN cord-028721-x6f26ahr 4095 2 may may MD cord-028721-x6f26ahr 4095 3 reduce reduce VB cord-028721-x6f26ahr 4095 4 the the DT cord-028721-x6f26ahr 4095 5 risk risk NN cord-028721-x6f26ahr 4095 6 of of IN cord-028721-x6f26ahr 4095 7 germ germ NN cord-028721-x6f26ahr 4095 8 cell cell NN cord-028721-x6f26ahr 4095 9 loss loss NN cord-028721-x6f26ahr 4095 10 in in IN cord-028721-x6f26ahr 4095 11 boys boy NNS cord-028721-x6f26ahr 4095 12 with with IN cord-028721-x6f26ahr 4095 13 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4095 14 Early early JJ cord-028721-x6f26ahr 4095 15 orchiopexy orchiopexy NN cord-028721-x6f26ahr 4095 16 : : : cord-028721-x6f26ahr 4095 17 prepubertal prepubertal JJ cord-028721-x6f26ahr 4095 18 intratubular intratubular JJ cord-028721-x6f26ahr 4095 19 germ germ NN cord-028721-x6f26ahr 4095 20 cell cell NN cord-028721-x6f26ahr 4095 21 neoplasia neoplasia NN cord-028721-x6f26ahr 4095 22 and and CC cord-028721-x6f26ahr 4095 23 fertility fertility NN cord-028721-x6f26ahr 4095 24 outcome outcome NN cord-028721-x6f26ahr 4095 25 Testicular testicular JJ cord-028721-x6f26ahr 4095 26 cancer cancer NN cord-028721-x6f26ahr 4095 27 and and CC cord-028721-x6f26ahr 4095 28 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4095 29 Cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4095 30 and and CC cord-028721-x6f26ahr 4095 31 testicular testicular NN cord-028721-x6f26ahr 4096 1 neoplasia neoplasia NNP cord-028721-x6f26ahr 4096 2 Testicular Testicular NNP cord-028721-x6f26ahr 4096 3 maldescent maldescent NN cord-028721-x6f26ahr 4096 4 and and CC cord-028721-x6f26ahr 4096 5 infertility infertility NN cord-028721-x6f26ahr 4096 6 Histology histology NN cord-028721-x6f26ahr 4096 7 of of IN cord-028721-x6f26ahr 4096 8 testicular testicular JJ cord-028721-x6f26ahr 4096 9 biopsies biopsy NNS cord-028721-x6f26ahr 4096 10 taken take VBN cord-028721-x6f26ahr 4096 11 at at IN cord-028721-x6f26ahr 4096 12 operation operation NN cord-028721-x6f26ahr 4096 13 for for IN cord-028721-x6f26ahr 4096 14 bilateral bilateral JJ cord-028721-x6f26ahr 4096 15 maldescended maldescended JJ cord-028721-x6f26ahr 4096 16 testes testis NNS cord-028721-x6f26ahr 4096 17 in in IN cord-028721-x6f26ahr 4096 18 relation relation NN cord-028721-x6f26ahr 4096 19 to to IN cord-028721-x6f26ahr 4096 20 fertility fertility NN cord-028721-x6f26ahr 4096 21 in in IN cord-028721-x6f26ahr 4096 22 adulthood adulthood NN cord-028721-x6f26ahr 4097 1 Semen semen NN cord-028721-x6f26ahr 4097 2 analysis analysis NN cord-028721-x6f26ahr 4097 3 in in IN cord-028721-x6f26ahr 4097 4 patients patient NNS cord-028721-x6f26ahr 4097 5 operated operate VBN cord-028721-x6f26ahr 4097 6 on on IN cord-028721-x6f26ahr 4097 7 for for IN cord-028721-x6f26ahr 4097 8 impalpable impalpable JJ cord-028721-x6f26ahr 4097 9 testes testis NNS cord-028721-x6f26ahr 4097 10 Fertility fertility NN cord-028721-x6f26ahr 4097 11 in in IN cord-028721-x6f26ahr 4097 12 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4097 13 : : : cord-028721-x6f26ahr 4097 14 an an DT cord-028721-x6f26ahr 4097 15 overview overview NN cord-028721-x6f26ahr 4097 16 in in IN cord-028721-x6f26ahr 4097 17 1987 1987 CD cord-028721-x6f26ahr 4097 18 Paternity paternity NN cord-028721-x6f26ahr 4097 19 and and CC cord-028721-x6f26ahr 4097 20 hormone hormone NN cord-028721-x6f26ahr 4097 21 levels level NNS cord-028721-x6f26ahr 4097 22 after after IN cord-028721-x6f26ahr 4097 23 unilateral unilateral JJ cord-028721-x6f26ahr 4097 24 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4097 25 : : : cord-028721-x6f26ahr 4097 26 association association NN cord-028721-x6f26ahr 4097 27 with with IN cord-028721-x6f26ahr 4097 28 pretreatment pretreatment NNP cord-028721-x6f26ahr 4097 29 testicular testicular NNP cord-028721-x6f26ahr 4097 30 location location NN cord-028721-x6f26ahr 4098 1 No no DT cord-028721-x6f26ahr 4098 2 relationship relationship NN cord-028721-x6f26ahr 4098 3 of of IN cord-028721-x6f26ahr 4098 4 testicular testicular JJ cord-028721-x6f26ahr 4098 5 size size NN cord-028721-x6f26ahr 4098 6 at at IN cord-028721-x6f26ahr 4098 7 orchiopexy orchiopexy NNP cord-028721-x6f26ahr 4098 8 with with IN cord-028721-x6f26ahr 4098 9 fertility fertility NN cord-028721-x6f26ahr 4098 10 in in IN cord-028721-x6f26ahr 4098 11 men man NNS cord-028721-x6f26ahr 4098 12 who who WP cord-028721-x6f26ahr 4098 13 previously previously RB cord-028721-x6f26ahr 4098 14 had have VBD cord-028721-x6f26ahr 4098 15 unilateral unilateral JJ cord-028721-x6f26ahr 4098 16 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4098 17 Fertility Fertility NNP cord-028721-x6f26ahr 4098 18 potential potential NN cord-028721-x6f26ahr 4098 19 : : : cord-028721-x6f26ahr 4098 20 a a DT cord-028721-x6f26ahr 4098 21 comparison comparison NN cord-028721-x6f26ahr 4098 22 of of IN cord-028721-x6f26ahr 4098 23 intra intra JJ cord-028721-x6f26ahr 4098 24 - - JJ cord-028721-x6f26ahr 4098 25 abdominal abdominal JJ cord-028721-x6f26ahr 4098 26 and and CC cord-028721-x6f26ahr 4098 27 intracanalicular intracanalicular JJ cord-028721-x6f26ahr 4098 28 testes testis NNS cord-028721-x6f26ahr 4098 29 by by IN cord-028721-x6f26ahr 4098 30 age age NN cord-028721-x6f26ahr 4098 31 groups group NNS cord-028721-x6f26ahr 4098 32 in in IN cord-028721-x6f26ahr 4098 33 children child NNS cord-028721-x6f26ahr 4098 34 Surgical surgical JJ cord-028721-x6f26ahr 4098 35 mangeament mangeament NN cord-028721-x6f26ahr 4098 36 of of IN cord-028721-x6f26ahr 4098 37 undescended undescended JJ cord-028721-x6f26ahr 4098 38 testis testis NN cord-028721-x6f26ahr 4098 39 : : : cord-028721-x6f26ahr 4098 40 retrospective retrospective JJ cord-028721-x6f26ahr 4098 41 study study NN cord-028721-x6f26ahr 4098 42 of of IN cord-028721-x6f26ahr 4098 43 potential potential JJ cord-028721-x6f26ahr 4098 44 fertility fertility NN cord-028721-x6f26ahr 4098 45 in in IN cord-028721-x6f26ahr 4098 46 274 274 CD cord-028721-x6f26ahr 4098 47 cases case NNS cord-028721-x6f26ahr 4098 48 orchiopexy orchiopexy NN cord-028721-x6f26ahr 4098 49 and and CC cord-028721-x6f26ahr 4098 50 infertility infertility NN cord-028721-x6f26ahr 4098 51 : : : cord-028721-x6f26ahr 4098 52 a a DT cord-028721-x6f26ahr 4098 53 critical critical JJ cord-028721-x6f26ahr 4098 54 long long JJ cord-028721-x6f26ahr 4098 55 - - HYPH cord-028721-x6f26ahr 4098 56 term term NN cord-028721-x6f26ahr 4098 57 retrospective retrospective JJ cord-028721-x6f26ahr 4098 58 analysis analysis NN cord-028721-x6f26ahr 4099 1 The the DT cord-028721-x6f26ahr 4099 2 importance importance NN cord-028721-x6f26ahr 4099 3 of of IN cord-028721-x6f26ahr 4099 4 mini mini NN cord-028721-x6f26ahr 4099 5 - - JJ cord-028721-x6f26ahr 4099 6 puberty puberty JJ cord-028721-x6f26ahr 4099 7 for for IN cord-028721-x6f26ahr 4099 8 fertility fertility NN cord-028721-x6f26ahr 4099 9 in in IN cord-028721-x6f26ahr 4099 10 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4099 11 Cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4099 12 : : : cord-028721-x6f26ahr 4099 13 aspects aspect NNS cord-028721-x6f26ahr 4099 14 of of IN cord-028721-x6f26ahr 4099 15 fertility fertility NN cord-028721-x6f26ahr 4099 16 References reference NNS cord-028721-x6f26ahr 4099 17 and and CC cord-028721-x6f26ahr 4099 18 neoplasms neoplasm NNS cord-028721-x6f26ahr 4099 19 . . . cord-028721-x6f26ahr 4100 1 A a DT cord-028721-x6f26ahr 4100 2 study study NN cord-028721-x6f26ahr 4100 3 including include VBG cord-028721-x6f26ahr 4100 4 data datum NNS cord-028721-x6f26ahr 4100 5 of of IN cord-028721-x6f26ahr 4100 6 1,335 1,335 CD cord-028721-x6f26ahr 4100 7 consecutive consecutive JJ cord-028721-x6f26ahr 4100 8 boys boy NNS cord-028721-x6f26ahr 4100 9 who who WP cord-028721-x6f26ahr 4100 10 underwent undergo VBD cord-028721-x6f26ahr 4100 11 testicular testicular JJ cord-028721-x6f26ahr 4100 12 biopsy biopsy NN cord-028721-x6f26ahr 4100 13 simultaneously simultaneously RB cord-028721-x6f26ahr 4100 14 with with IN cord-028721-x6f26ahr 4100 15 surgery surgery NN cord-028721-x6f26ahr 4100 16 for for IN cord-028721-x6f26ahr 4100 17 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4100 18 Experience experience NN cord-028721-x6f26ahr 4100 19 of of IN cord-028721-x6f26ahr 4100 20 screening screening NN cord-028721-x6f26ahr 4100 21 for for IN cord-028721-x6f26ahr 4100 22 carcinoma carcinoma NN cord-028721-x6f26ahr 4100 23 - - HYPH cord-028721-x6f26ahr 4100 24 in in IN cord-028721-x6f26ahr 4100 25 - - HYPH cord-028721-x6f26ahr 4100 26 situ situ NN cord-028721-x6f26ahr 4100 27 of of IN cord-028721-x6f26ahr 4100 28 the the DT cord-028721-x6f26ahr 4100 29 testis testis NN cord-028721-x6f26ahr 4100 30 among among IN cord-028721-x6f26ahr 4100 31 young young JJ cord-028721-x6f26ahr 4100 32 men man NNS cord-028721-x6f26ahr 4100 33 with with IN cord-028721-x6f26ahr 4100 34 surgically surgically RB cord-028721-x6f26ahr 4100 35 corrected correct VBN cord-028721-x6f26ahr 4100 36 maldescended maldescended JJ cord-028721-x6f26ahr 4100 37 testes testis NNS cord-028721-x6f26ahr 4100 38 Distribution distribution NN cord-028721-x6f26ahr 4100 39 of of IN cord-028721-x6f26ahr 4100 40 carcinoma carcinoma NN cord-028721-x6f26ahr 4100 41 - - HYPH cord-028721-x6f26ahr 4100 42 in in IN cord-028721-x6f26ahr 4100 43 - - HYPH cord-028721-x6f26ahr 4100 44 situ situ NN cord-028721-x6f26ahr 4100 45 in in IN cord-028721-x6f26ahr 4100 46 testes testis NNS cord-028721-x6f26ahr 4100 47 from from IN cord-028721-x6f26ahr 4100 48 infertile infertile JJ cord-028721-x6f26ahr 4100 49 men man NNS cord-028721-x6f26ahr 4100 50 Carcinoma carcinoma NN cord-028721-x6f26ahr 4100 51 - - HYPH cord-028721-x6f26ahr 4100 52 in in NN cord-028721-x6f26ahr 4100 53 - - HYPH cord-028721-x6f26ahr 4100 54 situ situ NN cord-028721-x6f26ahr 4100 55 of of IN cord-028721-x6f26ahr 4100 56 the the DT cord-028721-x6f26ahr 4100 57 testis testis NN cord-028721-x6f26ahr 4100 58 : : : cord-028721-x6f26ahr 4100 59 aneuploid aneuploid JJ cord-028721-x6f26ahr 4100 60 cells cell NNS cord-028721-x6f26ahr 4100 61 in in IN cord-028721-x6f26ahr 4100 62 semen semen NN cord-028721-x6f26ahr 4100 63 Cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4100 64 and and CC cord-028721-x6f26ahr 4100 65 testicular testicular JJ cord-028721-x6f26ahr 4100 66 neoplasia neoplasia NN cord-028721-x6f26ahr 4100 67 Testicular Testicular NNP cord-028721-x6f26ahr 4100 68 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4100 69 : : : cord-028721-x6f26ahr 4100 70 sonographic sonographic NNP cord-028721-x6f26ahr 4100 71 features feature VBZ cord-028721-x6f26ahr 4100 72 with with IN cord-028721-x6f26ahr 4100 73 pathologic pathologic JJ cord-028721-x6f26ahr 4100 74 correlation correlation NN cord-028721-x6f26ahr 4100 75 Testicular Testicular NNP cord-028721-x6f26ahr 4100 76 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4100 77 in in IN cord-028721-x6f26ahr 4100 78 a a DT cord-028721-x6f26ahr 4100 79 child child NN cord-028721-x6f26ahr 4100 80 with with IN cord-028721-x6f26ahr 4100 81 torsion torsion NN cord-028721-x6f26ahr 4100 82 of of IN cord-028721-x6f26ahr 4100 83 the the DT cord-028721-x6f26ahr 4100 84 appendix appendix NN cord-028721-x6f26ahr 4100 85 testis testis NN cord-028721-x6f26ahr 4100 86 Testicular Testicular NNP cord-028721-x6f26ahr 4100 87 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4100 88 occurring occur VBG cord-028721-x6f26ahr 4100 89 in in IN cord-028721-x6f26ahr 4100 90 a a DT cord-028721-x6f26ahr 4100 91 postorchidopexy postorchidopexy NN cord-028721-x6f26ahr 4100 92 testis testis NN cord-028721-x6f26ahr 4100 93 Microcalcifi Microcalcifi NNP cord-028721-x6f26ahr 4100 94 cations cation NNS cord-028721-x6f26ahr 4100 95 in in IN cord-028721-x6f26ahr 4100 96 testicular testicular JJ cord-028721-x6f26ahr 4100 97 malignancy malignancy NN cord-028721-x6f26ahr 4100 98 : : : cord-028721-x6f26ahr 4100 99 diagnostic diagnostic JJ cord-028721-x6f26ahr 4100 100 tool tool NN cord-028721-x6f26ahr 4100 101 in in IN cord-028721-x6f26ahr 4100 102 occult occult JJ cord-028721-x6f26ahr 4100 103 tumor tumor NN cord-028721-x6f26ahr 4100 104 ? ? . cord-028721-x6f26ahr 4101 1 Testicular testicular JJ cord-028721-x6f26ahr 4101 2 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4101 3 with with IN cord-028721-x6f26ahr 4101 4 sterility sterility NN cord-028721-x6f26ahr 4101 5 Testicular Testicular NNP cord-028721-x6f26ahr 4101 6 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4101 7 in in IN cord-028721-x6f26ahr 4102 1 male male JJ cord-028721-x6f26ahr 4102 2 infertility infertility NN cord-028721-x6f26ahr 4102 3 Microlitiasis Microlitiasis NNP cord-028721-x6f26ahr 4102 4 testicular testicular NN cord-028721-x6f26ahr 4102 5 asociada asociada NNP cord-028721-x6f26ahr 4102 6 a a DT cord-028721-x6f26ahr 4102 7 infertilidad infertilidad NNP cord-028721-x6f26ahr 4102 8 Painful Painful NNP cord-028721-x6f26ahr 4102 9 testicular testicular NNP cord-028721-x6f26ahr 4102 10 lithiasis lithiasis NN cord-028721-x6f26ahr 4102 11 Testicular Testicular NNP cord-028721-x6f26ahr 4102 12 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4102 13 : : : cord-028721-x6f26ahr 4103 1 diagnosis diagnosis NN cord-028721-x6f26ahr 4103 2 associated associate VBN cord-028721-x6f26ahr 4103 3 with with IN cord-028721-x6f26ahr 4103 4 orchialgia orchialgia NNP cord-028721-x6f26ahr 4103 5 Idiopathic Idiopathic NNP cord-028721-x6f26ahr 4103 6 testicular testicular NNP cord-028721-x6f26ahr 4103 7 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4103 8 . . . cord-028721-x6f26ahr 4104 1 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4104 2 study study NN cord-028721-x6f26ahr 4104 3 Testicular Testicular NNP cord-028721-x6f26ahr 4104 4 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4104 5 in in IN cord-028721-x6f26ahr 4104 6 a a DT cord-028721-x6f26ahr 4104 7 UK UK NNP cord-028721-x6f26ahr 4104 8 population population NN cord-028721-x6f26ahr 4104 9 : : : cord-028721-x6f26ahr 4105 1 its -PRON- PRP$ cord-028721-x6f26ahr 4105 2 incidence incidence NN cord-028721-x6f26ahr 4105 3 , , , cord-028721-x6f26ahr 4105 4 associations association NNS cord-028721-x6f26ahr 4105 5 and and CC cord-028721-x6f26ahr 4105 6 follow follow NN cord-028721-x6f26ahr 4105 7 - - HYPH cord-028721-x6f26ahr 4105 8 up up NN cord-028721-x6f26ahr 4105 9 Testicular Testicular NNP cord-028721-x6f26ahr 4105 10 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4105 11 is be VBZ cord-028721-x6f26ahr 4105 12 associated associate VBN cord-028721-x6f26ahr 4105 13 with with IN cord-028721-x6f26ahr 4105 14 testicular testicular JJ cord-028721-x6f26ahr 4105 15 pathology pathology NN cord-028721-x6f26ahr 4105 16 Testicular Testicular NNP cord-028721-x6f26ahr 4105 17 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4105 18 -a -a : cord-028721-x6f26ahr 4105 19 possibly possibly RB cord-028721-x6f26ahr 4105 20 premalignant premalignant JJ cord-028721-x6f26ahr 4105 21 condition condition NN cord-028721-x6f26ahr 4106 1 The the DT cord-028721-x6f26ahr 4106 2 prevalence prevalence NN cord-028721-x6f26ahr 4106 3 of of IN cord-028721-x6f26ahr 4106 4 testicular testicular JJ cord-028721-x6f26ahr 4106 5 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4106 6 in in IN cord-028721-x6f26ahr 4106 7 an an DT cord-028721-x6f26ahr 4106 8 asymptomatic asymptomatic JJ cord-028721-x6f26ahr 4106 9 population population NN cord-028721-x6f26ahr 4106 10 of of IN cord-028721-x6f26ahr 4106 11 men man NNS cord-028721-x6f26ahr 4106 12 18 18 CD cord-028721-x6f26ahr 4106 13 to to TO cord-028721-x6f26ahr 4106 14 35 35 CD cord-028721-x6f26ahr 4106 15 years year NNS cord-028721-x6f26ahr 4106 16 old old JJ cord-028721-x6f26ahr 4106 17 Testicular Testicular NNP cord-028721-x6f26ahr 4106 18 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4106 19 : : : cord-028721-x6f26ahr 4106 20 prevalence prevalence NN cord-028721-x6f26ahr 4106 21 and and CC cord-028721-x6f26ahr 4106 22 tumor tumor NN cord-028721-x6f26ahr 4106 23 risk risk NN cord-028721-x6f26ahr 4106 24 in in IN cord-028721-x6f26ahr 4106 25 a a DT cord-028721-x6f26ahr 4106 26 population population NN cord-028721-x6f26ahr 4106 27 referred refer VBN cord-028721-x6f26ahr 4106 28 for for IN cord-028721-x6f26ahr 4106 29 scrotal scrotal JJ cord-028721-x6f26ahr 4106 30 sonography sonography NN cord-028721-x6f26ahr 4106 31 Testicular testicular JJ cord-028721-x6f26ahr 4106 32 calcifi calcifi NN cord-028721-x6f26ahr 4106 33 cation cation NN cord-028721-x6f26ahr 4106 34 and and CC cord-028721-x6f26ahr 4106 35 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4106 36 : : : cord-028721-x6f26ahr 4106 37 association association NNP cord-028721-x6f26ahr 4106 38 with with IN cord-028721-x6f26ahr 4106 39 primary primary JJ cord-028721-x6f26ahr 4106 40 intra intra JJ cord-028721-x6f26ahr 4106 41 - - JJ cord-028721-x6f26ahr 4106 42 testicular testicular JJ cord-028721-x6f26ahr 4106 43 malignancy malignancy NN cord-028721-x6f26ahr 4106 44 in in IN cord-028721-x6f26ahr 4106 45 3,477 3,477 CD cord-028721-x6f26ahr 4106 46 patients patient NNS cord-028721-x6f26ahr 4106 47 Testicular Testicular NNP cord-028721-x6f26ahr 4106 48 microlithiasis microlithiasi NNS cord-028721-x6f26ahr 4106 49 , , , cord-028721-x6f26ahr 4106 50 a a DT cord-028721-x6f26ahr 4106 51 premalignant premalignant JJ cord-028721-x6f26ahr 4106 52 condition condition NN cord-028721-x6f26ahr 4106 53 : : : cord-028721-x6f26ahr 4106 54 prevalence prevalence NN cord-028721-x6f26ahr 4106 55 , , , cord-028721-x6f26ahr 4106 56 histopathologic histopathologic NNP cord-028721-x6f26ahr 4106 57 fi fi NNP cord-028721-x6f26ahr 4106 58 ndings nding NNS cord-028721-x6f26ahr 4106 59 , , , cord-028721-x6f26ahr 4106 60 and and CC cord-028721-x6f26ahr 4106 61 relation relation NN cord-028721-x6f26ahr 4106 62 to to IN cord-028721-x6f26ahr 4106 63 testicular testicular JJ cord-028721-x6f26ahr 4106 64 tumor tumor NN cord-028721-x6f26ahr 4107 1 Seminal seminal JJ cord-028721-x6f26ahr 4107 2 profi profi FW cord-028721-x6f26ahr 4107 3 le le FW cord-028721-x6f26ahr 4107 4 of of IN cord-028721-x6f26ahr 4107 5 subjects subject NNS cord-028721-x6f26ahr 4107 6 with with IN cord-028721-x6f26ahr 4107 7 testicular testicular NN cord-028721-x6f26ahr 4108 1 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4108 2 and and CC cord-028721-x6f26ahr 4108 3 testicular testicular JJ cord-028721-x6f26ahr 4108 4 calcifi calcifi NN cord-028721-x6f26ahr 4108 5 cations cation NNS cord-028721-x6f26ahr 4109 1 Bilateral bilateral JJ cord-028721-x6f26ahr 4109 2 testicular testicular NNP cord-028721-x6f26ahr 4109 3 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4109 4 predicts predict VBZ cord-028721-x6f26ahr 4109 5 the the DT cord-028721-x6f26ahr 4109 6 presence presence NN cord-028721-x6f26ahr 4109 7 of of IN cord-028721-x6f26ahr 4109 8 the the DT cord-028721-x6f26ahr 4109 9 precursor precursor NN cord-028721-x6f26ahr 4109 10 of of IN cord-028721-x6f26ahr 4109 11 testicular testicular JJ cord-028721-x6f26ahr 4109 12 germ germ NN cord-028721-x6f26ahr 4109 13 cell cell NN cord-028721-x6f26ahr 4109 14 tumors tumor NNS cord-028721-x6f26ahr 4109 15 in in IN cord-028721-x6f26ahr 4109 16 subfertile subfertile NN cord-028721-x6f26ahr 4109 17 men man NNS cord-028721-x6f26ahr 4109 18 Testicular Testicular NNP cord-028721-x6f26ahr 4109 19 nicrolithiasis nicrolithiasis NN cord-028721-x6f26ahr 4109 20 and and CC cord-028721-x6f26ahr 4109 21 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4109 22 : : : cord-028721-x6f26ahr 4109 23 ultrasound ultrasound NN cord-028721-x6f26ahr 4109 24 analysis analysis NN cord-028721-x6f26ahr 4109 25 after after IN cord-028721-x6f26ahr 4109 26 orchidopexy orchidopexy NNP cord-028721-x6f26ahr 4109 27 Testicular Testicular NNP cord-028721-x6f26ahr 4109 28 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4109 29 . . . cord-028721-x6f26ahr 4110 1 a a DT cord-028721-x6f26ahr 4110 2 benign benign JJ cord-028721-x6f26ahr 4110 3 condition condition NN cord-028721-x6f26ahr 4110 4 with with IN cord-028721-x6f26ahr 4110 5 a a DT cord-028721-x6f26ahr 4110 6 malignant malignant JJ cord-028721-x6f26ahr 4110 7 association association NN cord-028721-x6f26ahr 4110 8 Testicular Testicular NNP cord-028721-x6f26ahr 4110 9 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 10 : : : cord-028721-x6f26ahr 4110 11 a a DT cord-028721-x6f26ahr 4110 12 review review NN cord-028721-x6f26ahr 4110 13 and and CC cord-028721-x6f26ahr 4110 14 its -PRON- PRP$ cord-028721-x6f26ahr 4110 15 association association NN cord-028721-x6f26ahr 4110 16 with with IN cord-028721-x6f26ahr 4110 17 testicular testicular NNP cord-028721-x6f26ahr 4110 18 cancer cancer NN cord-028721-x6f26ahr 4110 19 Testicular Testicular NNP cord-028721-x6f26ahr 4110 20 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 21 heralding herald VBG cord-028721-x6f26ahr 4110 22 mixed mixed JJ cord-028721-x6f26ahr 4110 23 germ germ NN cord-028721-x6f26ahr 4110 24 cell cell NN cord-028721-x6f26ahr 4110 25 tumor tumor NN cord-028721-x6f26ahr 4110 26 of of IN cord-028721-x6f26ahr 4110 27 the the DT cord-028721-x6f26ahr 4110 28 testis testis NN cord-028721-x6f26ahr 4110 29 in in IN cord-028721-x6f26ahr 4110 30 a a DT cord-028721-x6f26ahr 4110 31 boy boy NN cord-028721-x6f26ahr 4110 32 Signifi Signifi NNP cord-028721-x6f26ahr 4110 33 cance cance NN cord-028721-x6f26ahr 4110 34 of of IN cord-028721-x6f26ahr 4110 35 testicular testicular NNP cord-028721-x6f26ahr 4110 36 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 37 Yolk Yolk NNP cord-028721-x6f26ahr 4110 38 sac sac NN cord-028721-x6f26ahr 4110 39 tumor tumor NN cord-028721-x6f26ahr 4110 40 and and CC cord-028721-x6f26ahr 4110 41 testicular testicular NNP cord-028721-x6f26ahr 4110 42 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 43 Testicular Testicular NNP cord-028721-x6f26ahr 4110 44 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 45 in in IN cord-028721-x6f26ahr 4110 46 children child NNS cord-028721-x6f26ahr 4110 47 : : : cord-028721-x6f26ahr 4110 48 sonographic sonographic NNP cord-028721-x6f26ahr 4110 49 features feature NNS cord-028721-x6f26ahr 4110 50 and and CC cord-028721-x6f26ahr 4110 51 clinical clinical JJ cord-028721-x6f26ahr 4110 52 implications implication NNS cord-028721-x6f26ahr 4110 53 Identifi Identifi NNP cord-028721-x6f26ahr 4110 54 cation cation NN cord-028721-x6f26ahr 4110 55 of of IN cord-028721-x6f26ahr 4110 56 seminiferous seminiferous JJ cord-028721-x6f26ahr 4110 57 tubule tubule NNP cord-028721-x6f26ahr 4110 58 aberrations aberration NNS cord-028721-x6f26ahr 4110 59 and and CC cord-028721-x6f26ahr 4110 60 a a DT cord-028721-x6f26ahr 4110 61 low low JJ cord-028721-x6f26ahr 4110 62 incidence incidence NN cord-028721-x6f26ahr 4110 63 of of IN cord-028721-x6f26ahr 4110 64 testicular testicular JJ cord-028721-x6f26ahr 4110 65 microliths microlith NNS cord-028721-x6f26ahr 4110 66 associated associate VBN cord-028721-x6f26ahr 4110 67 with with IN cord-028721-x6f26ahr 4110 68 the the DT cord-028721-x6f26ahr 4110 69 development development NN cord-028721-x6f26ahr 4110 70 of of IN cord-028721-x6f26ahr 4110 71 azoospermia azoospermia NNP cord-028721-x6f26ahr 4110 72 Raman Raman NNP cord-028721-x6f26ahr 4110 73 spectroscopic spectroscopic JJ cord-028721-x6f26ahr 4110 74 analysis analysis NN cord-028721-x6f26ahr 4110 75 identifi identifi NNP cord-028721-x6f26ahr 4110 76 es es NNP cord-028721-x6f26ahr 4110 77 testicular testicular NNP cord-028721-x6f26ahr 4110 78 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 79 as as IN cord-028721-x6f26ahr 4110 80 intratubular intratubular NNP cord-028721-x6f26ahr 4110 81 hydroxyapatite hydroxyapatite NNP cord-028721-x6f26ahr 4110 82 Testicular Testicular NNP cord-028721-x6f26ahr 4110 83 calcifi calcifi NN cord-028721-x6f26ahr 4110 84 cation cation NN cord-028721-x6f26ahr 4110 85 in in IN cord-028721-x6f26ahr 4110 86 a a DT cord-028721-x6f26ahr 4110 87 4-year 4-year JJ cord-028721-x6f26ahr 4110 88 - - HYPH cord-028721-x6f26ahr 4110 89 old old JJ cord-028721-x6f26ahr 4110 90 boy boy NN cord-028721-x6f26ahr 4110 91 The the DT cord-028721-x6f26ahr 4110 92 origin origin NN cord-028721-x6f26ahr 4110 93 of of IN cord-028721-x6f26ahr 4110 94 testicular testicular NNP cord-028721-x6f26ahr 4110 95 microliths microliths NNPS cord-028721-x6f26ahr 4110 96 Testicular Testicular NNP cord-028721-x6f26ahr 4110 97 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 98 in in IN cord-028721-x6f26ahr 4110 99 2 2 CD cord-028721-x6f26ahr 4110 100 children child NNS cord-028721-x6f26ahr 4110 101 with with IN cord-028721-x6f26ahr 4110 102 bilateral bilateral JJ cord-028721-x6f26ahr 4110 103 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4110 104 Pulmonary pulmonary JJ cord-028721-x6f26ahr 4110 105 alveolar alveolar NN cord-028721-x6f26ahr 4110 106 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 107 with with IN cord-028721-x6f26ahr 4110 108 involvement involvement NN cord-028721-x6f26ahr 4110 109 of of IN cord-028721-x6f26ahr 4110 110 the the DT cord-028721-x6f26ahr 4110 111 sympathetic sympathetic JJ cord-028721-x6f26ahr 4110 112 nervous nervous JJ cord-028721-x6f26ahr 4110 113 system system NN cord-028721-x6f26ahr 4110 114 and and CC cord-028721-x6f26ahr 4110 115 gonads gonad NNS cord-028721-x6f26ahr 4110 116 Testicular testicular JJ cord-028721-x6f26ahr 4110 117 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 118 and and CC cord-028721-x6f26ahr 4110 119 concomitant concomitant JJ cord-028721-x6f26ahr 4110 120 testicular testicular JJ cord-028721-x6f26ahr 4110 121 intraepithelial intraepithelial JJ cord-028721-x6f26ahr 4110 122 neoplasia neoplasia NN cord-028721-x6f26ahr 4110 123 Increased increase VBN cord-028721-x6f26ahr 4110 124 risk risk NN cord-028721-x6f26ahr 4110 125 of of IN cord-028721-x6f26ahr 4110 126 carcinoma carcinoma NN cord-028721-x6f26ahr 4110 127 in in IN cord-028721-x6f26ahr 4110 128 situ situ NN cord-028721-x6f26ahr 4110 129 in in IN cord-028721-x6f26ahr 4110 130 patients patient NNS cord-028721-x6f26ahr 4110 131 with with IN cord-028721-x6f26ahr 4110 132 testicular testicular JJ cord-028721-x6f26ahr 4110 133 germ germ NN cord-028721-x6f26ahr 4110 134 cell cell NN cord-028721-x6f26ahr 4110 135 cancer cancer NN cord-028721-x6f26ahr 4110 136 with with IN cord-028721-x6f26ahr 4110 137 ultrasonic ultrasonic JJ cord-028721-x6f26ahr 4110 138 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 139 in in IN cord-028721-x6f26ahr 4110 140 the the DT cord-028721-x6f26ahr 4110 141 contralateral contralateral JJ cord-028721-x6f26ahr 4110 142 testicle testicle NN cord-028721-x6f26ahr 4110 143 Testicular Testicular NNP cord-028721-x6f26ahr 4110 144 carcinoma carcinoma NN cord-028721-x6f26ahr 4110 145 in in IN cord-028721-x6f26ahr 4110 146 a a DT cord-028721-x6f26ahr 4110 147 patient patient NN cord-028721-x6f26ahr 4110 148 with with IN cord-028721-x6f26ahr 4110 149 previously previously RB cord-028721-x6f26ahr 4110 150 demostrated demostrate VBN cord-028721-x6f26ahr 4110 151 testicular testicular NNP cord-028721-x6f26ahr 4110 152 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 153 Testicular Testicular NNP cord-028721-x6f26ahr 4110 154 microlithiasis microlithiasis NNP cord-028721-x6f26ahr 4110 155 and and CC cord-028721-x6f26ahr 4110 156 subsequent subsequent JJ cord-028721-x6f26ahr 4110 157 development development NN cord-028721-x6f26ahr 4110 158 of of IN cord-028721-x6f26ahr 4110 159 metastatic metastatic JJ cord-028721-x6f26ahr 4110 160 germ germ NN cord-028721-x6f26ahr 4110 161 cell cell NN cord-028721-x6f26ahr 4110 162 tumor tumor NN cord-028721-x6f26ahr 4110 163 Detection detection NN cord-028721-x6f26ahr 4110 164 of of IN cord-028721-x6f26ahr 4110 165 testicular testicular JJ cord-028721-x6f26ahr 4110 166 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4110 167 by by IN cord-028721-x6f26ahr 4110 168 sonography sonography NNP cord-028721-x6f26ahr 4111 1 The the DT cord-028721-x6f26ahr 4111 2 interval interval NN cord-028721-x6f26ahr 4111 3 of of IN cord-028721-x6f26ahr 4111 4 development development NN cord-028721-x6f26ahr 4111 5 of of IN cord-028721-x6f26ahr 4111 6 testicular testicular JJ cord-028721-x6f26ahr 4111 7 carcinoma carcinoma NN cord-028721-x6f26ahr 4111 8 in in IN cord-028721-x6f26ahr 4111 9 a a DT cord-028721-x6f26ahr 4111 10 patient patient NN cord-028721-x6f26ahr 4111 11 with with IN cord-028721-x6f26ahr 4111 12 previously previously RB cord-028721-x6f26ahr 4111 13 demonstrated demonstrate VBN cord-028721-x6f26ahr 4111 14 testicular testicular JJ cord-028721-x6f26ahr 4111 15 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4111 16 Surveillance Surveillance NNP cord-028721-x6f26ahr 4111 17 of of IN cord-028721-x6f26ahr 4111 18 testicular testicular JJ cord-028721-x6f26ahr 4111 19 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4111 20 ? ? . cord-028721-x6f26ahr 4112 1 Results result NNS cord-028721-x6f26ahr 4112 2 of of IN cord-028721-x6f26ahr 4112 3 an an DT cord-028721-x6f26ahr 4112 4 UK UK NNP cord-028721-x6f26ahr 4112 5 based base VBN cord-028721-x6f26ahr 4112 6 national national JJ cord-028721-x6f26ahr 4112 7 questionnaire questionnaire NN cord-028721-x6f26ahr 4112 8 survey survey NN cord-028721-x6f26ahr 4112 9 Testicular Testicular NNP cord-028721-x6f26ahr 4112 10 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4112 11 : : : cord-028721-x6f26ahr 4112 12 US US NNP cord-028721-x6f26ahr 4112 13 follow follow VB cord-028721-x6f26ahr 4112 14 - - HYPH cord-028721-x6f26ahr 4112 15 up up NN cord-028721-x6f26ahr 4112 16 Testicular Testicular NNP cord-028721-x6f26ahr 4112 17 microlithiasis microlithiasis NN cord-028721-x6f26ahr 4112 18 as as IN cord-028721-x6f26ahr 4112 19 a a DT cord-028721-x6f26ahr 4112 20 predictor predictor NN cord-028721-x6f26ahr 4112 21 of of IN cord-028721-x6f26ahr 4112 22 intratubular intratubular JJ cord-028721-x6f26ahr 4112 23 germ germ NN cord-028721-x6f26ahr 4112 24 cell cell NN cord-028721-x6f26ahr 4112 25 neoplasia neoplasia NN cord-028721-x6f26ahr 4112 26 Microlithiasis Microlithiasis NNP cord-028721-x6f26ahr 4112 27 of of IN cord-028721-x6f26ahr 4112 28 the the DT cord-028721-x6f26ahr 4112 29 epididymis epididymis NN cord-028721-x6f26ahr 4112 30 and and CC cord-028721-x6f26ahr 4112 31 the the DT cord-028721-x6f26ahr 4112 32 rete rete NN cord-028721-x6f26ahr 4112 33 testis testis NN cord-028721-x6f26ahr 4112 34 Three three CD cord-028721-x6f26ahr 4112 35 novel novel NN cord-028721-x6f26ahr 4112 36 SRY SRY NNP cord-028721-x6f26ahr 4112 37 mutations mutation NNS cord-028721-x6f26ahr 4112 38 in in IN cord-028721-x6f26ahr 4112 39 XY XY NNP cord-028721-x6f26ahr 4112 40 gonadal gonadal JJ cord-028721-x6f26ahr 4112 41 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4112 42 and and CC cord-028721-x6f26ahr 4112 43 the the DT cord-028721-x6f26ahr 4112 44 enigma enigma NN cord-028721-x6f26ahr 4112 45 of of IN cord-028721-x6f26ahr 4112 46 XY XY NNP cord-028721-x6f26ahr 4112 47 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4112 48 cases case NNS cord-028721-x6f26ahr 4112 49 without without IN cord-028721-x6f26ahr 4112 50 SRY SRY NNP cord-028721-x6f26ahr 4112 51 mutations mutation NNS cord-028721-x6f26ahr 4113 1 A a DT cord-028721-x6f26ahr 4113 2 novel novel JJ cord-028721-x6f26ahr 4113 3 postzygotic postzygotic JJ cord-028721-x6f26ahr 4113 4 nonsense nonsense NN cord-028721-x6f26ahr 4113 5 mutation mutation NN cord-028721-x6f26ahr 4113 6 in in IN cord-028721-x6f26ahr 4113 7 SRY SRY NNP cord-028721-x6f26ahr 4113 8 in in IN cord-028721-x6f26ahr 4113 9 familial familial JJ cord-028721-x6f26ahr 4113 10 XY XY NNP cord-028721-x6f26ahr 4113 11 gonadal gonadal NN cord-028721-x6f26ahr 4113 12 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4113 13 Mutations Mutations NNPS cord-028721-x6f26ahr 4113 14 in in IN cord-028721-x6f26ahr 4113 15 SRY SRY NNP cord-028721-x6f26ahr 4113 16 and and CC cord-028721-x6f26ahr 4113 17 WT1 wt1 JJ cord-028721-x6f26ahr 4113 18 genes gene NNS cord-028721-x6f26ahr 4113 19 required require VBN cord-028721-x6f26ahr 4113 20 for for IN cord-028721-x6f26ahr 4113 21 gonadal gonadal JJ cord-028721-x6f26ahr 4113 22 development development NN cord-028721-x6f26ahr 4113 23 are be VBP cord-028721-x6f26ahr 4113 24 not not RB cord-028721-x6f26ahr 4113 25 responsible responsible JJ cord-028721-x6f26ahr 4113 26 for for IN cord-028721-x6f26ahr 4113 27 XY XY NNP cord-028721-x6f26ahr 4113 28 partial partial JJ cord-028721-x6f26ahr 4113 29 gonadal gonadal NN cord-028721-x6f26ahr 4113 30 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4113 31 Pathology Pathology NNP cord-028721-x6f26ahr 4113 32 of of IN cord-028721-x6f26ahr 4113 33 46,XY 46,xy CD cord-028721-x6f26ahr 4113 34 pure pure JJ cord-028721-x6f26ahr 4113 35 gonadal gonadal JJ cord-028721-x6f26ahr 4113 36 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4113 37 : : : cord-028721-x6f26ahr 4114 1 absence absence NN cord-028721-x6f26ahr 4114 2 of of IN cord-028721-x6f26ahr 4114 3 testis testis NN cord-028721-x6f26ahr 4114 4 differentiation differentiation NN cord-028721-x6f26ahr 4114 5 associated associate VBN cord-028721-x6f26ahr 4114 6 with with IN cord-028721-x6f26ahr 4114 7 mutations mutation NNS cord-028721-x6f26ahr 4114 8 in in IN cord-028721-x6f26ahr 4114 9 the the DT cord-028721-x6f26ahr 4114 10 testis testis NN cord-028721-x6f26ahr 4114 11 - - HYPH cord-028721-x6f26ahr 4114 12 determining determine VBG cord-028721-x6f26ahr 4114 13 factor factor NN cord-028721-x6f26ahr 4114 14 XY XY NNP cord-028721-x6f26ahr 4114 15 gonadal gonadal JJ cord-028721-x6f26ahr 4114 16 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4114 17 : : : cord-028721-x6f26ahr 4115 1 Genetic genetic JJ cord-028721-x6f26ahr 4115 2 heterogeneity heterogeneity NN cord-028721-x6f26ahr 4115 3 based base VBN cord-028721-x6f26ahr 4115 4 upon upon IN cord-028721-x6f26ahr 4115 5 clinical clinical JJ cord-028721-x6f26ahr 4115 6 observations observation NNS cord-028721-x6f26ahr 4115 7 , , , cord-028721-x6f26ahr 4115 8 H H NNP cord-028721-x6f26ahr 4115 9 - - HYPH cord-028721-x6f26ahr 4115 10 Y Y NNP cord-028721-x6f26ahr 4115 11 antigen antigen NN cord-028721-x6f26ahr 4115 12 status status NN cord-028721-x6f26ahr 4115 13 and and CC cord-028721-x6f26ahr 4115 14 segregations segregation NNS cord-028721-x6f26ahr 4115 15 analysis analysis NN cord-028721-x6f26ahr 4115 16 Chronic Chronic NNP cord-028721-x6f26ahr 4115 17 renal renal JJ cord-028721-x6f26ahr 4115 18 disease disease NN cord-028721-x6f26ahr 4115 19 , , , cord-028721-x6f26ahr 4115 20 myotonic myotonic JJ cord-028721-x6f26ahr 4115 21 dystrophy dystrophy NN cord-028721-x6f26ahr 4115 22 , , , cord-028721-x6f26ahr 4115 23 and and CC cord-028721-x6f26ahr 4115 24 gonadoblastoma gonadoblastoma NN cord-028721-x6f26ahr 4115 25 in in IN cord-028721-x6f26ahr 4115 26 XY XY NNP cord-028721-x6f26ahr 4115 27 gonadal gonadal NN cord-028721-x6f26ahr 4115 28 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4115 29 Renal renal JJ cord-028721-x6f26ahr 4115 30 failure failure NN cord-028721-x6f26ahr 4115 31 with with IN cord-028721-x6f26ahr 4115 32 XY XY NNP cord-028721-x6f26ahr 4115 33 gonadal gonadal NN cord-028721-x6f26ahr 4115 34 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4115 35 : : : cord-028721-x6f26ahr 4116 1 Report report NN cord-028721-x6f26ahr 4116 2 of of IN cord-028721-x6f26ahr 4116 3 the the DT cord-028721-x6f26ahr 4116 4 second second JJ cord-028721-x6f26ahr 4116 5 case case NN cord-028721-x6f26ahr 4116 6 A a DT cord-028721-x6f26ahr 4116 7 syndrome syndrome NN cord-028721-x6f26ahr 4116 8 of of IN cord-028721-x6f26ahr 4116 9 chronic chronic JJ cord-028721-x6f26ahr 4116 10 renal renal JJ cord-028721-x6f26ahr 4116 11 failure failure NN cord-028721-x6f26ahr 4116 12 and and CC cord-028721-x6f26ahr 4116 13 XY XY NNP cord-028721-x6f26ahr 4116 14 gonadal gonadal JJ cord-028721-x6f26ahr 4116 15 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4116 16 in in IN cord-028721-x6f26ahr 4116 17 young young JJ cord-028721-x6f26ahr 4116 18 phenotypic phenotypic NNS cord-028721-x6f26ahr 4116 19 females female NNS cord-028721-x6f26ahr 4116 20 without without IN cord-028721-x6f26ahr 4116 21 genital genital JJ cord-028721-x6f26ahr 4116 22 ambiguity ambiguity NN cord-028721-x6f26ahr 4116 23 Atypical atypical JJ cord-028721-x6f26ahr 4116 24 presentation presentation NN cord-028721-x6f26ahr 4116 25 of of IN cord-028721-x6f26ahr 4116 26 Denys Denys NNP cord-028721-x6f26ahr 4116 27 - - HYPH cord-028721-x6f26ahr 4116 28 Drash Drash NNP cord-028721-x6f26ahr 4116 29 syndrome syndrome NN cord-028721-x6f26ahr 4116 30 in in IN cord-028721-x6f26ahr 4116 31 a a DT cord-028721-x6f26ahr 4116 32 female female NN cord-028721-x6f26ahr 4116 33 with with IN cord-028721-x6f26ahr 4116 34 a a DT cord-028721-x6f26ahr 4116 35 novel novel NN cord-028721-x6f26ahr 4116 36 WT1 WT1 HYPH cord-028721-x6f26ahr 4116 37 gene gene NN cord-028721-x6f26ahr 4116 38 mutation mutation NN cord-028721-x6f26ahr 4116 39 Molecular molecular JJ cord-028721-x6f26ahr 4116 40 analysis analysis NN cord-028721-x6f26ahr 4116 41 of of IN cord-028721-x6f26ahr 4116 42 Frasier Frasier NNP cord-028721-x6f26ahr 4116 43 syndrome syndrome NN cord-028721-x6f26ahr 4116 44 : : : cord-028721-x6f26ahr 4116 45 mutation mutation NN cord-028721-x6f26ahr 4116 46 in in IN cord-028721-x6f26ahr 4116 47 the the DT cord-028721-x6f26ahr 4116 48 WT1 WT1 NNP cord-028721-x6f26ahr 4116 49 gene gene NN cord-028721-x6f26ahr 4116 50 in in IN cord-028721-x6f26ahr 4116 51 a a DT cord-028721-x6f26ahr 4116 52 girl girl NN cord-028721-x6f26ahr 4116 53 with with IN cord-028721-x6f26ahr 4116 54 gonadal gonadal JJ cord-028721-x6f26ahr 4116 55 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 4116 56 and and CC cord-028721-x6f26ahr 4116 57 nephronophthisis nephronophthisis NN cord-028721-x6f26ahr 4116 58 Frasier Frasier NNP cord-028721-x6f26ahr 4116 59 syndrome syndrome NN cord-028721-x6f26ahr 4116 60 : : : cord-028721-x6f26ahr 4116 61 a a DT cord-028721-x6f26ahr 4116 62 rare rare JJ cord-028721-x6f26ahr 4116 63 syndrome syndrome NN cord-028721-x6f26ahr 4116 64 with with IN cord-028721-x6f26ahr 4116 65 WT1 wt1 JJ cord-028721-x6f26ahr 4116 66 gene gene NN cord-028721-x6f26ahr 4116 67 mutation mutation NN cord-028721-x6f26ahr 4116 68 in in IN cord-028721-x6f26ahr 4116 69 pediatric pediatric JJ cord-028721-x6f26ahr 4116 70 urology urology NNP cord-028721-x6f26ahr 4116 71 XY XY NNP cord-028721-x6f26ahr 4116 72 siblings sibling NNS cord-028721-x6f26ahr 4116 73 with with IN cord-028721-x6f26ahr 4116 74 inadequate inadequate JJ cord-028721-x6f26ahr 4116 75 virilization virilization NN cord-028721-x6f26ahr 4116 76 and and CC cord-028721-x6f26ahr 4116 77 CNS CNS NNP cord-028721-x6f26ahr 4116 78 defi defi NNP cord-028721-x6f26ahr 4116 79 ciency ciency NNP cord-028721-x6f26ahr 4116 80 Testicular Testicular NNP cord-028721-x6f26ahr 4116 81 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4116 82 and and CC cord-028721-x6f26ahr 4116 83 mental mental JJ cord-028721-x6f26ahr 4116 84 retardation retardation NN cord-028721-x6f26ahr 4116 85 in in IN cord-028721-x6f26ahr 4116 86 two two CD cord-028721-x6f26ahr 4116 87 incompletely incompletely RB cord-028721-x6f26ahr 4116 88 masculinized masculinize VBN cord-028721-x6f26ahr 4116 89 XYsiblings XYsiblings NNPS cord-028721-x6f26ahr 4116 90 Analysis Analysis NNP cord-028721-x6f26ahr 4116 91 of of IN cord-028721-x6f26ahr 4116 92 the the DT cord-028721-x6f26ahr 4116 93 testisdetermining testisdetermining NN cord-028721-x6f26ahr 4116 94 gene gene NN cord-028721-x6f26ahr 4116 95 SRY SRY NNP cord-028721-x6f26ahr 4116 96 in in IN cord-028721-x6f26ahr 4116 97 patients patient NNS cord-028721-x6f26ahr 4116 98 with with IN cord-028721-x6f26ahr 4116 99 XY XY NNP cord-028721-x6f26ahr 4116 100 gonadal gonadal NN cord-028721-x6f26ahr 4116 101 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4117 1 The the DT cord-028721-x6f26ahr 4117 2 Gardner Gardner NNP cord-028721-x6f26ahr 4117 3 - - HYPH cord-028721-x6f26ahr 4117 4 Silengo Silengo NNP cord-028721-x6f26ahr 4117 5 - - HYPH cord-028721-x6f26ahr 4117 6 Wachtel Wachtel NNP cord-028721-x6f26ahr 4117 7 or or CC cord-028721-x6f26ahr 4117 8 genitor genitor NN cord-028721-x6f26ahr 4117 9 - - HYPH cord-028721-x6f26ahr 4117 10 palato palato JJ cord-028721-x6f26ahr 4117 11 - - HYPH cord-028721-x6f26ahr 4117 12 cardiac cardiac JJ cord-028721-x6f26ahr 4117 13 syndrome syndrome NN cord-028721-x6f26ahr 4117 14 : : : cord-028721-x6f26ahr 4118 1 Male male JJ cord-028721-x6f26ahr 4118 2 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4118 3 with with IN cord-028721-x6f26ahr 4118 4 micrognathia micrognathia NNP cord-028721-x6f26ahr 4118 5 , , , cord-028721-x6f26ahr 4118 6 cleft cleft NN cord-028721-x6f26ahr 4118 7 palate palate NN cord-028721-x6f26ahr 4118 8 , , , cord-028721-x6f26ahr 4118 9 and and CC cord-028721-x6f26ahr 4118 10 conotruncal conotruncal JJ cord-028721-x6f26ahr 4118 11 cardiac cardiac JJ cord-028721-x6f26ahr 4118 12 defects defect NNS cord-028721-x6f26ahr 4118 13 XY XY NNP cord-028721-x6f26ahr 4118 14 gonadal gonadal JJ cord-028721-x6f26ahr 4118 15 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 16 associated associate VBN cord-028721-x6f26ahr 4118 17 with with IN cord-028721-x6f26ahr 4118 18 a a DT cord-028721-x6f26ahr 4118 19 multiple multiple JJ cord-028721-x6f26ahr 4118 20 pterygium pterygium NN cord-028721-x6f26ahr 4118 21 syndrome syndrome NN cord-028721-x6f26ahr 4118 22 phenotype phenotype NN cord-028721-x6f26ahr 4118 23 XY XY NNP cord-028721-x6f26ahr 4118 24 pure pure JJ cord-028721-x6f26ahr 4118 25 gonadal gonadal JJ cord-028721-x6f26ahr 4118 26 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 27 : : : cord-028721-x6f26ahr 4118 28 a a DT cord-028721-x6f26ahr 4118 29 case case NN cord-028721-x6f26ahr 4118 30 with with IN cord-028721-x6f26ahr 4118 31 Graves Graves NNP cord-028721-x6f26ahr 4118 32 ' ' POS cord-028721-x6f26ahr 4118 33 disease disease NN cord-028721-x6f26ahr 4118 34 A a DT cord-028721-x6f26ahr 4118 35 case case NN cord-028721-x6f26ahr 4118 36 of of IN cord-028721-x6f26ahr 4118 37 gonadal gonadal JJ cord-028721-x6f26ahr 4118 38 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 39 , , , cord-028721-x6f26ahr 4118 40 breast breast NN cord-028721-x6f26ahr 4118 41 development development NN cord-028721-x6f26ahr 4118 42 , , , cord-028721-x6f26ahr 4118 43 Graves Graves NNP cord-028721-x6f26ahr 4118 44 ' ' POS cord-028721-x6f26ahr 4118 45 disease disease NN cord-028721-x6f26ahr 4118 46 , , , cord-028721-x6f26ahr 4118 47 and and CC cord-028721-x6f26ahr 4118 48 low low JJ cord-028721-x6f26ahr 4118 49 bone bone NN cord-028721-x6f26ahr 4118 50 mass mass NN cord-028721-x6f26ahr 4118 51 Alopecia Alopecia NNP cord-028721-x6f26ahr 4118 52 universalis universalis NN cord-028721-x6f26ahr 4118 53 congenita congenita NN cord-028721-x6f26ahr 4118 54 , , , cord-028721-x6f26ahr 4118 55 XY XY NNP cord-028721-x6f26ahr 4118 56 gonadal gonadal NNP cord-028721-x6f26ahr 4118 57 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 58 and and CC cord-028721-x6f26ahr 4118 59 laryngomalacia laryngomalacia NNP cord-028721-x6f26ahr 4118 60 : : : cord-028721-x6f26ahr 4118 61 a a DT cord-028721-x6f26ahr 4118 62 novel novel JJ cord-028721-x6f26ahr 4118 63 malformation malformation NN cord-028721-x6f26ahr 4118 64 syndrome syndrome NN cord-028721-x6f26ahr 4118 65 Alopecia Alopecia NNP cord-028721-x6f26ahr 4118 66 congenita congenita NNP cord-028721-x6f26ahr 4118 67 universalis universalis NNP cord-028721-x6f26ahr 4118 68 , , , cord-028721-x6f26ahr 4118 69 microcephaly microcephaly NNS cord-028721-x6f26ahr 4118 70 , , , cord-028721-x6f26ahr 4118 71 cutis cutis NNP cord-028721-x6f26ahr 4118 72 marmorata marmorata NNP cord-028721-x6f26ahr 4118 73 , , , cord-028721-x6f26ahr 4118 74 short short JJ cord-028721-x6f26ahr 4118 75 stature stature NN cord-028721-x6f26ahr 4118 76 and and CC cord-028721-x6f26ahr 4118 77 XY XY NNP cord-028721-x6f26ahr 4118 78 gonadal gonadal NNP cord-028721-x6f26ahr 4118 79 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 80 : : : cord-028721-x6f26ahr 4118 81 variable variable JJ cord-028721-x6f26ahr 4118 82 expression expression NN cord-028721-x6f26ahr 4118 83 of of IN cord-028721-x6f26ahr 4118 84 El El NNP cord-028721-x6f26ahr 4118 85 - - HYPH cord-028721-x6f26ahr 4118 86 Shanti Shanti NNP cord-028721-x6f26ahr 4118 87 syndrome syndrome NN cord-028721-x6f26ahr 4118 88 Syndromal Syndromal NNP cord-028721-x6f26ahr 4118 89 ( ( -LRB- cord-028721-x6f26ahr 4118 90 and and CC cord-028721-x6f26ahr 4118 91 nonsyndromal nonsyndromal JJ cord-028721-x6f26ahr 4118 92 ) ) -RRB- cord-028721-x6f26ahr 4118 93 forms form NNS cord-028721-x6f26ahr 4118 94 of of IN cord-028721-x6f26ahr 4118 95 male male JJ cord-028721-x6f26ahr 4118 96 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4118 97 Familial familial JJ cord-028721-x6f26ahr 4118 98 ovarian ovarian NN cord-028721-x6f26ahr 4118 99 dysgerminomas dysgerminomas NN cord-028721-x6f26ahr 4118 100 ( ( -LRB- cord-028721-x6f26ahr 4118 101 Swyer Swyer NNP cord-028721-x6f26ahr 4118 102 syndrome syndrome NN cord-028721-x6f26ahr 4118 103 ) ) -RRB- cord-028721-x6f26ahr 4118 104 in in IN cord-028721-x6f26ahr 4118 105 females female NNS cord-028721-x6f26ahr 4118 106 associated associate VBN cord-028721-x6f26ahr 4118 107 with with IN cord-028721-x6f26ahr 4118 108 A a DT cord-028721-x6f26ahr 4118 109 new new JJ cord-028721-x6f26ahr 4118 110 familial familial JJ cord-028721-x6f26ahr 4118 111 syndrome syndrome NN cord-028721-x6f26ahr 4118 112 of of IN cord-028721-x6f26ahr 4118 113 46 46 CD cord-028721-x6f26ahr 4118 114 XY XY NNP cord-028721-x6f26ahr 4118 115 gonadal gonadal NN cord-028721-x6f26ahr 4118 116 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 117 with with IN cord-028721-x6f26ahr 4118 118 anomalies anomaly NNS cord-028721-x6f26ahr 4118 119 of of IN cord-028721-x6f26ahr 4118 120 ectodermal ectodermal NNS cord-028721-x6f26ahr 4118 121 and and CC cord-028721-x6f26ahr 4118 122 mesodermal mesodermal JJ cord-028721-x6f26ahr 4118 123 structural structural JJ cord-028721-x6f26ahr 4118 124 Familial familial JJ cord-028721-x6f26ahr 4118 125 XY XY NNP cord-028721-x6f26ahr 4118 126 gonadal gonadal NN cord-028721-x6f26ahr 4118 127 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 128 Familial familial JJ cord-028721-x6f26ahr 4118 129 XY XY NNP cord-028721-x6f26ahr 4118 130 gonadal gonadal NN cord-028721-x6f26ahr 4118 131 dysgenesis dysgenesis FW cord-028721-x6f26ahr 4118 132 XY XY NNP cord-028721-x6f26ahr 4118 133 gonadal gonadal JJ cord-028721-x6f26ahr 4118 134 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4118 135 : : : cord-028721-x6f26ahr 4119 1 Genetic genetic JJ cord-028721-x6f26ahr 4119 2 heterogeneity heterogeneity NN cord-028721-x6f26ahr 4119 3 based base VBN cord-028721-x6f26ahr 4119 4 upon upon IN cord-028721-x6f26ahr 4119 5 clinical clinical JJ cord-028721-x6f26ahr 4119 6 observations observation NNS cord-028721-x6f26ahr 4119 7 , , , cord-028721-x6f26ahr 4119 8 H H NNP cord-028721-x6f26ahr 4119 9 - - HYPH cord-028721-x6f26ahr 4119 10 Y Y NNP cord-028721-x6f26ahr 4119 11 antigen antigen NN cord-028721-x6f26ahr 4119 12 status status NN cord-028721-x6f26ahr 4119 13 and and CC cord-028721-x6f26ahr 4119 14 segregations segregation NNS cord-028721-x6f26ahr 4119 15 analysis analysis NN cord-028721-x6f26ahr 4119 16 The the DT cord-028721-x6f26ahr 4119 17 X x NN cord-028721-x6f26ahr 4119 18 linked link VBN cord-028721-x6f26ahr 4119 19 recessive recessive JJ cord-028721-x6f26ahr 4119 20 form form NN cord-028721-x6f26ahr 4119 21 of of IN cord-028721-x6f26ahr 4119 22 XY XY NNP cord-028721-x6f26ahr 4119 23 gonadal gonadal JJ cord-028721-x6f26ahr 4119 24 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4119 25 with with IN cord-028721-x6f26ahr 4119 26 high high JJ cord-028721-x6f26ahr 4119 27 incidende incidende NNP cord-028721-x6f26ahr 4119 28 of of IN cord-028721-x6f26ahr 4119 29 gonadal gonadal JJ cord-028721-x6f26ahr 4119 30 cell cell NN cord-028721-x6f26ahr 4119 31 tumors tumor NNS cord-028721-x6f26ahr 4119 32 : : : cord-028721-x6f26ahr 4119 33 Clinical clinical JJ cord-028721-x6f26ahr 4119 34 and and CC cord-028721-x6f26ahr 4119 35 genetic genetic JJ cord-028721-x6f26ahr 4119 36 studies study NNS cord-028721-x6f26ahr 4120 1 The the DT cord-028721-x6f26ahr 4120 2 relationship relationship NN cord-028721-x6f26ahr 4120 3 of of IN cord-028721-x6f26ahr 4120 4 neoplasia neoplasia NN cord-028721-x6f26ahr 4120 5 to to IN cord-028721-x6f26ahr 4120 6 disorders disorder NNS cord-028721-x6f26ahr 4120 7 of of IN cord-028721-x6f26ahr 4120 8 abnormal abnormal JJ cord-028721-x6f26ahr 4120 9 sexual sexual JJ cord-028721-x6f26ahr 4120 10 diferentiation diferentiation NN cord-028721-x6f26ahr 4120 11 XY XY NNP cord-028721-x6f26ahr 4120 12 gonadal gonadal JJ cord-028721-x6f26ahr 4120 13 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4120 14 : : : cord-028721-x6f26ahr 4120 15 evidence evidence NN cord-028721-x6f26ahr 4120 16 for for IN cord-028721-x6f26ahr 4120 17 autosomal autosomal JJ cord-028721-x6f26ahr 4120 18 dominant dominant JJ cord-028721-x6f26ahr 4120 19 transmission transmission NN cord-028721-x6f26ahr 4120 20 in in IN cord-028721-x6f26ahr 4120 21 a a DT cord-028721-x6f26ahr 4120 22 large large JJ cord-028721-x6f26ahr 4120 23 kindred kindred JJ cord-028721-x6f26ahr 4120 24 Gonadoblastomas Gonadoblastomas NNP cord-028721-x6f26ahr 4120 25 in in IN cord-028721-x6f26ahr 4120 26 5 5 CD cord-028721-x6f26ahr 4120 27 patients patient NNS cord-028721-x6f26ahr 4120 28 with with IN cord-028721-x6f26ahr 4120 29 46XY 46xy CD cord-028721-x6f26ahr 4120 30 gonadal gonadal JJ cord-028721-x6f26ahr 4120 31 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 4120 32 Familial Familial NNP cord-028721-x6f26ahr 4120 33 46,XX 46,xx CD cord-028721-x6f26ahr 4120 34 gonadal gonadal JJ cord-028721-x6f26ahr 4120 35 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4121 1 Pure pure JJ cord-028721-x6f26ahr 4121 2 gonadal gonadal JJ cord-028721-x6f26ahr 4121 3 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4121 4 XX xx NN cord-028721-x6f26ahr 4121 5 and and CC cord-028721-x6f26ahr 4121 6 XY XY NNP cord-028721-x6f26ahr 4121 7 : : : cord-028721-x6f26ahr 4121 8 observations observation NNS cord-028721-x6f26ahr 4121 9 in in IN cord-028721-x6f26ahr 4121 10 fi fi NN cord-028721-x6f26ahr 4121 11 fteen fteen NNP cord-028721-x6f26ahr 4121 12 patients patient NNS cord-028721-x6f26ahr 4121 13 Gonadal Gonadal NNP cord-028721-x6f26ahr 4121 14 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4121 15 in in IN cord-028721-x6f26ahr 4121 16 a a DT cord-028721-x6f26ahr 4121 17 patient patient NN cord-028721-x6f26ahr 4121 18 with with IN cord-028721-x6f26ahr 4121 19 an an DT cord-028721-x6f26ahr 4121 20 X x NN cord-028721-x6f26ahr 4122 1 ; ; : cord-028721-x6f26ahr 4122 2 3 3 CD cord-028721-x6f26ahr 4122 3 translocation translocation NN cord-028721-x6f26ahr 4122 4 : : : cord-028721-x6f26ahr 4122 5 case case NN cord-028721-x6f26ahr 4122 6 report report NN cord-028721-x6f26ahr 4122 7 and and CC cord-028721-x6f26ahr 4122 8 review review VB cord-028721-x6f26ahr 4122 9 Gonadal Gonadal NNP cord-028721-x6f26ahr 4122 10 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4122 11 , , , cord-028721-x6f26ahr 4122 12 intra intra JJ cord-028721-x6f26ahr 4122 13 - - JJ cord-028721-x6f26ahr 4122 14 X x JJ cord-028721-x6f26ahr 4122 15 chromosomal chromosomal JJ cord-028721-x6f26ahr 4122 16 insertion insertion NN cord-028721-x6f26ahr 4122 17 , , , cord-028721-x6f26ahr 4122 18 and and CC cord-028721-x6f26ahr 4122 19 possible possible JJ cord-028721-x6f26ahr 4122 20 position position NN cord-028721-x6f26ahr 4122 21 effect effect NN cord-028721-x6f26ahr 4122 22 in in IN cord-028721-x6f26ahr 4122 23 an an DT cord-028721-x6f26ahr 4122 24 otherwise otherwise RB cord-028721-x6f26ahr 4122 25 normal normal JJ cord-028721-x6f26ahr 4122 26 female female JJ cord-028721-x6f26ahr 4122 27 Ovarian ovarian JJ cord-028721-x6f26ahr 4122 28 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4122 29 with with IN cord-028721-x6f26ahr 4122 30 balanced balanced JJ cord-028721-x6f26ahr 4122 31 autosomal autosomal JJ cord-028721-x6f26ahr 4122 32 translocation translocation NN cord-028721-x6f26ahr 4122 33 A a DT cord-028721-x6f26ahr 4122 34 novel novel JJ cord-028721-x6f26ahr 4122 35 mutation mutation NN cord-028721-x6f26ahr 4122 36 in in IN cord-028721-x6f26ahr 4122 37 the the DT cord-028721-x6f26ahr 4122 38 FSH FSH NNP cord-028721-x6f26ahr 4122 39 receptor receptor NN cord-028721-x6f26ahr 4122 40 inhibiting inhibit VBG cord-028721-x6f26ahr 4122 41 signal signal NN cord-028721-x6f26ahr 4122 42 transduction transduction NN cord-028721-x6f26ahr 4122 43 and and CC cord-028721-x6f26ahr 4122 44 causing cause VBG cord-028721-x6f26ahr 4122 45 primary primary JJ cord-028721-x6f26ahr 4122 46 ovarian ovarian JJ cord-028721-x6f26ahr 4122 47 failure failure NN cord-028721-x6f26ahr 4122 48 A a DT cord-028721-x6f26ahr 4122 49 novel novel JJ cord-028721-x6f26ahr 4122 50 loss loss NN cord-028721-x6f26ahr 4122 51 of of IN cord-028721-x6f26ahr 4122 52 function function NN cord-028721-x6f26ahr 4122 53 mutation mutation NN cord-028721-x6f26ahr 4122 54 in in IN cord-028721-x6f26ahr 4122 55 exon exon NNP cord-028721-x6f26ahr 4122 56 10 10 CD cord-028721-x6f26ahr 4122 57 of of IN cord-028721-x6f26ahr 4122 58 the the DT cord-028721-x6f26ahr 4122 59 FSH FSH NNP cord-028721-x6f26ahr 4122 60 receptor receptor NN cord-028721-x6f26ahr 4122 61 gene gene NN cord-028721-x6f26ahr 4122 62 causing cause VBG cord-028721-x6f26ahr 4122 63 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 4122 64 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4122 65 : : : cord-028721-x6f26ahr 4122 66 clinical clinical JJ cord-028721-x6f26ahr 4122 67 and and CC cord-028721-x6f26ahr 4122 68 molecular molecular JJ cord-028721-x6f26ahr 4122 69 characteristics characteristic NNS cord-028721-x6f26ahr 4123 1 No no DT cord-028721-x6f26ahr 4123 2 evidence evidence NN cord-028721-x6f26ahr 4123 3 of of IN cord-028721-x6f26ahr 4123 4 mutations mutation NNS cord-028721-x6f26ahr 4123 5 in in IN cord-028721-x6f26ahr 4123 6 the the DT cord-028721-x6f26ahr 4123 7 follicle follicle NN cord-028721-x6f26ahr 4123 8 - - HYPH cord-028721-x6f26ahr 4123 9 stimulating stimulate VBG cord-028721-x6f26ahr 4123 10 hormone hormone NN cord-028721-x6f26ahr 4123 11 receptor receptor NN cord-028721-x6f26ahr 4123 12 gene gene NN cord-028721-x6f26ahr 4123 13 in in IN cord-028721-x6f26ahr 4123 14 Mexican mexican JJ cord-028721-x6f26ahr 4123 15 women woman NNS cord-028721-x6f26ahr 4123 16 with with IN cord-028721-x6f26ahr 4123 17 46,XX 46,xx CD cord-028721-x6f26ahr 4123 18 pure pure JJ cord-028721-x6f26ahr 4123 19 gonadal gonadal JJ cord-028721-x6f26ahr 4123 20 dysgenesis dysgenesis FW cord-028721-x6f26ahr 4123 21 Dysgerminoma Dysgerminoma NNP cord-028721-x6f26ahr 4123 22 and and CC cord-028721-x6f26ahr 4123 23 gonadal gonadal JJ cord-028721-x6f26ahr 4123 24 dysgenesis dysgenesis FW cord-028721-x6f26ahr 4123 25 in in IN cord-028721-x6f26ahr 4123 26 a a DT cord-028721-x6f26ahr 4123 27 46,XX 46,xx CD cord-028721-x6f26ahr 4123 28 female female NN cord-028721-x6f26ahr 4123 29 with with IN cord-028721-x6f26ahr 4123 30 no no DT cord-028721-x6f26ahr 4123 31 evidence evidence NN cord-028721-x6f26ahr 4123 32 of of IN cord-028721-x6f26ahr 4123 33 Y Y NNP cord-028721-x6f26ahr 4123 34 chromosomal chromosomal JJ cord-028721-x6f26ahr 4123 35 DNA DNA NNP cord-028721-x6f26ahr 4123 36 Dysgerminoma Dysgerminoma NNP cord-028721-x6f26ahr 4123 37 with with IN cord-028721-x6f26ahr 4123 38 syncytiotrophoblastic syncytiotrophoblastic JJ cord-028721-x6f26ahr 4123 39 giant giant JJ cord-028721-x6f26ahr 4123 40 cells cell NNS cord-028721-x6f26ahr 4124 1 References reference NNS cord-028721-x6f26ahr 4124 2 arising arise VBG cord-028721-x6f26ahr 4124 3 from from IN cord-028721-x6f26ahr 4124 4 46,XX 46,xx CD cord-028721-x6f26ahr 4124 5 pure pure JJ cord-028721-x6f26ahr 4124 6 gonadal gonadal JJ cord-028721-x6f26ahr 4124 7 dysgenesis dysgenesis FW cord-028721-x6f26ahr 4124 8 Familial familial JJ cord-028721-x6f26ahr 4124 9 dysgerminoma dysgerminoma NN cord-028721-x6f26ahr 4124 10 associated associate VBN cord-028721-x6f26ahr 4124 11 with with IN cord-028721-x6f26ahr 4124 12 46 46 CD cord-028721-x6f26ahr 4124 13 , , , cord-028721-x6f26ahr 4124 14 XX XX NNP cord-028721-x6f26ahr 4124 15 pure pure JJ cord-028721-x6f26ahr 4124 16 gonadal gonadal JJ cord-028721-x6f26ahr 4124 17 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4124 18 Prenatal prenatal JJ cord-028721-x6f26ahr 4124 19 and and CC cord-028721-x6f26ahr 4124 20 postnatal postnatal JJ cord-028721-x6f26ahr 4124 21 prevalence prevalence NN cord-028721-x6f26ahr 4124 22 of of IN cord-028721-x6f26ahr 4124 23 Turner Turner NNP cord-028721-x6f26ahr 4124 24 's 's POS cord-028721-x6f26ahr 4124 25 syndrome syndrome NN cord-028721-x6f26ahr 4125 1 : : : cord-028721-x6f26ahr 4125 2 a a DT cord-028721-x6f26ahr 4125 3 registry registry NN cord-028721-x6f26ahr 4125 4 study study NN cord-028721-x6f26ahr 4125 5 The the DT cord-028721-x6f26ahr 4125 6 distribution distribution NN cord-028721-x6f26ahr 4125 7 of of IN cord-028721-x6f26ahr 4125 8 chromosomal chromosomal JJ cord-028721-x6f26ahr 4125 9 genotypes genotype NNS cord-028721-x6f26ahr 4125 10 associated associate VBN cord-028721-x6f26ahr 4125 11 with with IN cord-028721-x6f26ahr 4125 12 Turner Turner NNP cord-028721-x6f26ahr 4125 13 's 's POS cord-028721-x6f26ahr 4125 14 syndrome syndrome NN cord-028721-x6f26ahr 4125 15 : : : cord-028721-x6f26ahr 4125 16 livebirth livebirth NN cord-028721-x6f26ahr 4125 17 prevalence prevalence NN cord-028721-x6f26ahr 4125 18 and and CC cord-028721-x6f26ahr 4125 19 evidence evidence NN cord-028721-x6f26ahr 4125 20 for for IN cord-028721-x6f26ahr 4125 21 dismissed dismiss VBN cord-028721-x6f26ahr 4125 22 fetal fetal JJ cord-028721-x6f26ahr 4125 23 mortality mortality NN cord-028721-x6f26ahr 4125 24 and and CC cord-028721-x6f26ahr 4125 25 severity severity NN cord-028721-x6f26ahr 4125 26 in in IN cord-028721-x6f26ahr 4125 27 genotypes genotype NNS cord-028721-x6f26ahr 4125 28 associated associate VBN cord-028721-x6f26ahr 4125 29 with with IN cord-028721-x6f26ahr 4125 30 structural structural JJ cord-028721-x6f26ahr 4125 31 X x NN cord-028721-x6f26ahr 4125 32 abnomalities abnomalitie NNS cord-028721-x6f26ahr 4125 33 or or CC cord-028721-x6f26ahr 4125 34 mosaicism mosaicism NN cord-028721-x6f26ahr 4125 35 Primary primary JJ cord-028721-x6f26ahr 4125 36 ovarian ovarian JJ cord-028721-x6f26ahr 4125 37 failure failure NN cord-028721-x6f26ahr 4125 38 Turner Turner NNP cord-028721-x6f26ahr 4125 39 syndrome syndrome NN cord-028721-x6f26ahr 4125 40 and and CC cord-028721-x6f26ahr 4125 41 female female JJ cord-028721-x6f26ahr 4125 42 sex sex NN cord-028721-x6f26ahr 4125 43 chromosome chromosome NN cord-028721-x6f26ahr 4125 44 aberrations aberration NNS cord-028721-x6f26ahr 4125 45 : : : cord-028721-x6f26ahr 4125 46 deduction deduction NN cord-028721-x6f26ahr 4125 47 of of IN cord-028721-x6f26ahr 4125 48 the the DT cord-028721-x6f26ahr 4125 49 principal principal JJ cord-028721-x6f26ahr 4125 50 factors factor NNS cord-028721-x6f26ahr 4125 51 involved involve VBN cord-028721-x6f26ahr 4125 52 in in IN cord-028721-x6f26ahr 4125 53 the the DT cord-028721-x6f26ahr 4125 54 development development NN cord-028721-x6f26ahr 4125 55 of of IN cord-028721-x6f26ahr 4125 56 clinical clinical JJ cord-028721-x6f26ahr 4125 57 features feature NNS cord-028721-x6f26ahr 4125 58 Turner Turner NNP cord-028721-x6f26ahr 4125 59 's 's POS cord-028721-x6f26ahr 4125 60 syndrome syndrome NN cord-028721-x6f26ahr 4126 1 The the DT cord-028721-x6f26ahr 4126 2 anatomy anatomy NN cord-028721-x6f26ahr 4126 3 and and CC cord-028721-x6f26ahr 4126 4 histology histology NN cord-028721-x6f26ahr 4126 5 of of IN cord-028721-x6f26ahr 4126 6 XO XO NNP cord-028721-x6f26ahr 4126 7 human human JJ cord-028721-x6f26ahr 4126 8 embryos embryo NNS cord-028721-x6f26ahr 4126 9 and and CC cord-028721-x6f26ahr 4126 10 fetuses fetus NNS cord-028721-x6f26ahr 4126 11 Principles principle NNS cord-028721-x6f26ahr 4126 12 of of IN cord-028721-x6f26ahr 4126 13 reproductive reproductive JJ cord-028721-x6f26ahr 4126 14 embryology embryology NN cord-028721-x6f26ahr 4126 15 Mammalian mammalian JJ cord-028721-x6f26ahr 4126 16 MutS MutS NNP cord-028721-x6f26ahr 4126 17 homologue homologue NN cord-028721-x6f26ahr 4126 18 5 5 CD cord-028721-x6f26ahr 4126 19 is be VBZ cord-028721-x6f26ahr 4126 20 required require VBN cord-028721-x6f26ahr 4126 21 for for IN cord-028721-x6f26ahr 4126 22 chromosome chromosome NN cord-028721-x6f26ahr 4126 23 pairing pair VBG cord-028721-x6f26ahr 4126 24 in in IN cord-028721-x6f26ahr 4126 25 meiosis meiosis NN cord-028721-x6f26ahr 4126 26 Accelerated accelerate VBN cord-028721-x6f26ahr 4126 27 germ germ NN cord-028721-x6f26ahr 4126 28 cell cell NN cord-028721-x6f26ahr 4126 29 apoptosis apoptosis NN cord-028721-x6f26ahr 4126 30 in in IN cord-028721-x6f26ahr 4126 31 sex sex NN cord-028721-x6f26ahr 4126 32 chromosome chromosome NN cord-028721-x6f26ahr 4126 33 aneuploid aneuploid JJ cord-028721-x6f26ahr 4126 34 fetal fetal JJ cord-028721-x6f26ahr 4126 35 human human JJ cord-028721-x6f26ahr 4126 36 gonads gonad NNS cord-028721-x6f26ahr 4126 37 Sex sex NN cord-028721-x6f26ahr 4126 38 chromosomes chromosome NNS cord-028721-x6f26ahr 4126 39 and and CC cord-028721-x6f26ahr 4126 40 sexlinked sexlinke VBD cord-028721-x6f26ahr 4126 41 genes genes NNPS cord-028721-x6f26ahr 4126 42 Gonadal Gonadal NNP cord-028721-x6f26ahr 4126 43 mixed mixed JJ cord-028721-x6f26ahr 4126 44 germ germ NN cord-028721-x6f26ahr 4126 45 cell cell NN cord-028721-x6f26ahr 4126 46 tumor tumor NN cord-028721-x6f26ahr 4126 47 combined combine VBN cord-028721-x6f26ahr 4126 48 with with IN cord-028721-x6f26ahr 4126 49 a a DT cord-028721-x6f26ahr 4126 50 large large JJ cord-028721-x6f26ahr 4126 51 hemangiomatous hemangiomatous JJ cord-028721-x6f26ahr 4126 52 lesion lesion NN cord-028721-x6f26ahr 4126 53 in in IN cord-028721-x6f26ahr 4126 54 a a DT cord-028721-x6f26ahr 4126 55 patient patient NN cord-028721-x6f26ahr 4126 56 with with IN cord-028721-x6f26ahr 4126 57 Turner Turner NNP cord-028721-x6f26ahr 4126 58 's 's POS cord-028721-x6f26ahr 4126 59 syndrome syndrome NN cord-028721-x6f26ahr 4126 60 and and CC cord-028721-x6f26ahr 4126 61 45,X/46,X 45,x/46,x CD cord-028721-x6f26ahr 4126 62 , , , cord-028721-x6f26ahr 4126 63 + + CC cord-028721-x6f26ahr 4126 64 mar mar NN cord-028721-x6f26ahr 4126 65 karyotype karyotype NNP cord-028721-x6f26ahr 4126 66 Gonadoblastoma Gonadoblastoma NNP cord-028721-x6f26ahr 4126 67 and and CC cord-028721-x6f26ahr 4126 68 Turner Turner NNP cord-028721-x6f26ahr 4127 1 syndrome syndrome NN cord-028721-x6f26ahr 4127 2 A a DT cord-028721-x6f26ahr 4127 3 review review NN cord-028721-x6f26ahr 4127 4 of of IN cord-028721-x6f26ahr 4127 5 41 41 CD cord-028721-x6f26ahr 4127 6 cases case NNS cord-028721-x6f26ahr 4127 7 with with IN cord-028721-x6f26ahr 4127 8 observations observation NNS cord-028721-x6f26ahr 4127 9 on on IN cord-028721-x6f26ahr 4127 10 testicular testicular JJ cord-028721-x6f26ahr 4127 11 histology histology NN cord-028721-x6f26ahr 4127 12 and and CC cord-028721-x6f26ahr 4127 13 function function VB cord-028721-x6f26ahr 4127 14 True true JJ cord-028721-x6f26ahr 4127 15 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 4127 16 presenting present VBG cord-028721-x6f26ahr 4127 17 as as IN cord-028721-x6f26ahr 4127 18 bilateral bilateral JJ cord-028721-x6f26ahr 4127 19 gynecomastia gynecomastia NN cord-028721-x6f26ahr 4127 20 in in IN cord-028721-x6f26ahr 4127 21 an an DT cord-028721-x6f26ahr 4127 22 adolescent adolescent JJ cord-028721-x6f26ahr 4127 23 phenotypic phenotypic NN cord-028721-x6f26ahr 4127 24 male male NN cord-028721-x6f26ahr 4127 25 Aetiological Aetiological NNP cord-028721-x6f26ahr 4127 26 diagnosis diagnosis NN cord-028721-x6f26ahr 4127 27 of of IN cord-028721-x6f26ahr 4127 28 male male JJ cord-028721-x6f26ahr 4127 29 sex sex NN cord-028721-x6f26ahr 4127 30 ambiguity ambiguity NN cord-028721-x6f26ahr 4127 31 : : : cord-028721-x6f26ahr 4127 32 a a DT cord-028721-x6f26ahr 4127 33 collaborative collaborative JJ cord-028721-x6f26ahr 4127 34 study study NN cord-028721-x6f26ahr 4127 35 Seminoma Seminoma NNP cord-028721-x6f26ahr 4127 36 in in IN cord-028721-x6f26ahr 4127 37 a a DT cord-028721-x6f26ahr 4127 38 46 46 CD cord-028721-x6f26ahr 4127 39 XX xx NN cord-028721-x6f26ahr 4127 40 true true JJ cord-028721-x6f26ahr 4127 41 hermaphrodite hermaphrodite JJ cord-028721-x6f26ahr 4127 42 with with IN cord-028721-x6f26ahr 4127 43 positive positive JJ cord-028721-x6f26ahr 4127 44 H h NN cord-028721-x6f26ahr 4127 45 - - HYPH cord-028721-x6f26ahr 4127 46 Y Y NNP cord-028721-x6f26ahr 4127 47 antigen antigen NN cord-028721-x6f26ahr 4127 48 . . . cord-028721-x6f26ahr 4128 1 A a DT cord-028721-x6f26ahr 4128 2 case case NN cord-028721-x6f26ahr 4128 3 report report NN cord-028721-x6f26ahr 4128 4 The the DT cord-028721-x6f26ahr 4128 5 gonads gonad NNS cord-028721-x6f26ahr 4128 6 of of IN cord-028721-x6f26ahr 4128 7 human human JJ cord-028721-x6f26ahr 4128 8 true true JJ cord-028721-x6f26ahr 4128 9 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 4129 1 True true JJ cord-028721-x6f26ahr 4129 2 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 4129 3 . . . cord-028721-x6f26ahr 4130 1 Clinical clinical JJ cord-028721-x6f26ahr 4130 2 morphological morphological JJ cord-028721-x6f26ahr 4130 3 and and CC cord-028721-x6f26ahr 4130 4 cytogenetic cytogenetic JJ cord-028721-x6f26ahr 4130 5 aspects aspect NNS cord-028721-x6f26ahr 4131 1 True true JJ cord-028721-x6f26ahr 4131 2 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 4131 3 : : : cord-028721-x6f26ahr 4131 4 geographical geographical JJ cord-028721-x6f26ahr 4131 5 distribution distribution NN cord-028721-x6f26ahr 4131 6 , , , cord-028721-x6f26ahr 4131 7 clinical clinical JJ cord-028721-x6f26ahr 4131 8 fi fi NN cord-028721-x6f26ahr 4131 9 ndings nding NNS cord-028721-x6f26ahr 4131 10 , , , cord-028721-x6f26ahr 4131 11 chromosomes chromosome NNS cord-028721-x6f26ahr 4131 12 and and CC cord-028721-x6f26ahr 4131 13 gonadal gonadal JJ cord-028721-x6f26ahr 4131 14 histology histology NN cord-028721-x6f26ahr 4132 1 True true JJ cord-028721-x6f26ahr 4132 2 hermaprhoditism hermaprhoditism NN cord-028721-x6f26ahr 4132 3 : : : cord-028721-x6f26ahr 4132 4 clinical clinical JJ cord-028721-x6f26ahr 4132 5 features feature NNS cord-028721-x6f26ahr 4132 6 , , , cord-028721-x6f26ahr 4132 7 genetic genetic JJ cord-028721-x6f26ahr 4132 8 variants variant NNS cord-028721-x6f26ahr 4132 9 and and CC cord-028721-x6f26ahr 4132 10 gonadal gonadal JJ cord-028721-x6f26ahr 4132 11 histology histology NN cord-028721-x6f26ahr 4132 12 Hormonal hormonal JJ cord-028721-x6f26ahr 4132 13 and and CC cord-028721-x6f26ahr 4132 14 molecular molecular JJ cord-028721-x6f26ahr 4132 15 genetic genetic JJ cord-028721-x6f26ahr 4132 16 fundings funding NNS cord-028721-x6f26ahr 4132 17 in in IN cord-028721-x6f26ahr 4132 18 46 46 CD cord-028721-x6f26ahr 4132 19 , , , cord-028721-x6f26ahr 4132 20 XX XX NNP cord-028721-x6f26ahr 4132 21 subjects subject NNS cord-028721-x6f26ahr 4132 22 with with IN cord-028721-x6f26ahr 4132 23 sexual sexual JJ cord-028721-x6f26ahr 4132 24 ambiguity ambiguity NN cord-028721-x6f26ahr 4132 25 and and CC cord-028721-x6f26ahr 4132 26 testicular testicular JJ cord-028721-x6f26ahr 4132 27 differentiation differentiation NN cord-028721-x6f26ahr 4133 1 Familial familial JJ cord-028721-x6f26ahr 4133 2 46XX 46xx CD cord-028721-x6f26ahr 4133 3 males male NNS cord-028721-x6f26ahr 4133 4 coexisting coexist VBG cord-028721-x6f26ahr 4133 5 with with IN cord-028721-x6f26ahr 4133 6 familial familial JJ cord-028721-x6f26ahr 4133 7 46,XX 46,xx CD cord-028721-x6f26ahr 4133 8 true true JJ cord-028721-x6f26ahr 4133 9 hermaphrodites hermaphrodite NNS cord-028721-x6f26ahr 4133 10 in in IN cord-028721-x6f26ahr 4133 11 same same JJ cord-028721-x6f26ahr 4133 12 pedigree pedigree NN cord-028721-x6f26ahr 4134 1 Partially partially RB cord-028721-x6f26ahr 4134 2 delected delecte VBN cord-028721-x6f26ahr 4134 3 SRY SRY NNP cord-028721-x6f26ahr 4134 4 gene gene NN cord-028721-x6f26ahr 4134 5 confi confi NN cord-028721-x6f26ahr 4134 6 ned ned NNP cord-028721-x6f26ahr 4134 7 to to IN cord-028721-x6f26ahr 4134 8 testicular testicular JJ cord-028721-x6f26ahr 4134 9 tissue tissue NN cord-028721-x6f26ahr 4134 10 in in IN cord-028721-x6f26ahr 4134 11 a a DT cord-028721-x6f26ahr 4134 12 46,XX 46,xx CD cord-028721-x6f26ahr 4134 13 true true JJ cord-028721-x6f26ahr 4134 14 hermaphrodite hermaphrodite NN cord-028721-x6f26ahr 4134 15 without without IN cord-028721-x6f26ahr 4134 16 SRY SRY NNP cord-028721-x6f26ahr 4134 17 in in IN cord-028721-x6f26ahr 4134 18 leukocytic leukocytic JJ cord-028721-x6f26ahr 4134 19 DNA DNA NNP cord-028721-x6f26ahr 4134 20 Pregnancy Pregnancy NNP cord-028721-x6f26ahr 4134 21 in in IN cord-028721-x6f26ahr 4134 22 a a DT cord-028721-x6f26ahr 4134 23 woman woman NN cord-028721-x6f26ahr 4134 24 with with IN cord-028721-x6f26ahr 4134 25 a a DT cord-028721-x6f26ahr 4134 26 Y Y NNP cord-028721-x6f26ahr 4134 27 chromosome chromosome NN cord-028721-x6f26ahr 4134 28 after after IN cord-028721-x6f26ahr 4134 29 removal removal NN cord-028721-x6f26ahr 4134 30 of of IN cord-028721-x6f26ahr 4134 31 an an DT cord-028721-x6f26ahr 4134 32 ovarian ovarian JJ cord-028721-x6f26ahr 4134 33 dysgerminoma dysgerminoma NN cord-028721-x6f26ahr 4134 34 Preservation Preservation NNP cord-028721-x6f26ahr 4134 35 of of IN cord-028721-x6f26ahr 4134 36 gonadal gonadal JJ cord-028721-x6f26ahr 4134 37 function function NN cord-028721-x6f26ahr 4134 38 in in IN cord-028721-x6f26ahr 4134 39 true true JJ cord-028721-x6f26ahr 4134 40 hermaphroditism hermaphroditism NN cord-028721-x6f26ahr 4134 41 Das Das NNP cord-028721-x6f26ahr 4134 42 syndrom syndrom NNP cord-028721-x6f26ahr 4134 43 des des FW cord-028721-x6f26ahr 4134 44 Pseudohermaphroditismus Pseudohermaphroditismus NNP cord-028721-x6f26ahr 4134 45 masculinus masculinus FW cord-028721-x6f26ahr 4134 46 bei bei NNP cord-028721-x6f26ahr 4134 47 kongenitaler kongenitaler NNP cord-028721-x6f26ahr 4135 1 Nebennierensiden Nebennierensiden NNP cord-028721-x6f26ahr 4135 2 - - HYPH cord-028721-x6f26ahr 4135 3 Hyperplasie Hyperplasie NNP cord-028721-x6f26ahr 4135 4 ohne ohne NNP cord-028721-x6f26ahr 4136 1 Androgenüberproduktion androgenüberproduktion NN cord-028721-x6f26ahr 4137 1 A a DT cord-028721-x6f26ahr 4137 2 novel novel JJ cord-028721-x6f26ahr 4137 3 compound compound NN cord-028721-x6f26ahr 4137 4 heterozygous heterozygous JJ cord-028721-x6f26ahr 4137 5 mutation mutation NN cord-028721-x6f26ahr 4137 6 in in IN cord-028721-x6f26ahr 4137 7 the the DT cord-028721-x6f26ahr 4137 8 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4137 9 acute acute JJ cord-028721-x6f26ahr 4137 10 regulatory regulatory JJ cord-028721-x6f26ahr 4137 11 protein protein NN cord-028721-x6f26ahr 4137 12 gene gene NN cord-028721-x6f26ahr 4137 13 in in IN cord-028721-x6f26ahr 4137 14 a a DT cord-028721-x6f26ahr 4137 15 patient patient NN cord-028721-x6f26ahr 4137 16 with with IN cord-028721-x6f26ahr 4137 17 congenital congenital JJ cord-028721-x6f26ahr 4137 18 lipoid lipoid JJ cord-028721-x6f26ahr 4137 19 adrenal adrenal JJ cord-028721-x6f26ahr 4137 20 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4137 21 Molecular Molecular NNP cord-028721-x6f26ahr 4137 22 and and CC cord-028721-x6f26ahr 4137 23 structural structural JJ cord-028721-x6f26ahr 4137 24 analysis analysis NN cord-028721-x6f26ahr 4137 25 of of IN cord-028721-x6f26ahr 4137 26 two two CD cord-028721-x6f26ahr 4137 27 novel novel JJ cord-028721-x6f26ahr 4137 28 StAR StAR NNP cord-028721-x6f26ahr 4137 29 mutation mutation NN cord-028721-x6f26ahr 4137 30 in in IN cord-028721-x6f26ahr 4137 31 patients patient NNS cord-028721-x6f26ahr 4137 32 with with IN cord-028721-x6f26ahr 4137 33 lipoid lipoid NNP cord-028721-x6f26ahr 4137 34 congenital congenital JJ cord-028721-x6f26ahr 4137 35 adrenal adrenal JJ cord-028721-x6f26ahr 4137 36 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4138 1 A a DT cord-028721-x6f26ahr 4138 2 novel novel JJ cord-028721-x6f26ahr 4138 3 mutation mutation NN cord-028721-x6f26ahr 4139 1 L260P L260P NNP cord-028721-x6f26ahr 4139 2 of of IN cord-028721-x6f26ahr 4139 3 the the DT cord-028721-x6f26ahr 4139 4 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4139 5 acute acute JJ cord-028721-x6f26ahr 4139 6 regulatory regulatory JJ cord-028721-x6f26ahr 4139 7 protein protein NN cord-028721-x6f26ahr 4139 8 gene gene NN cord-028721-x6f26ahr 4139 9 in in IN cord-028721-x6f26ahr 4139 10 three three CD cord-028721-x6f26ahr 4139 11 unrelated unrelated JJ cord-028721-x6f26ahr 4139 12 patients patient NNS cord-028721-x6f26ahr 4139 13 of of IN cord-028721-x6f26ahr 4139 14 Swiss swiss JJ cord-028721-x6f26ahr 4139 15 ancestry ancestry NN cord-028721-x6f26ahr 4139 16 with with IN cord-028721-x6f26ahr 4139 17 congenital congenital JJ cord-028721-x6f26ahr 4139 18 lipoid lipoid NN cord-028721-x6f26ahr 4140 1 adrenal adrenal JJ cord-028721-x6f26ahr 4140 2 hyperplasia hyperplasia NNP cord-028721-x6f26ahr 4140 3 Mutations Mutations NNPS cord-028721-x6f26ahr 4140 4 in in IN cord-028721-x6f26ahr 4140 5 the the DT cord-028721-x6f26ahr 4140 6 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4140 7 acute acute JJ cord-028721-x6f26ahr 4140 8 regulatory regulatory JJ cord-028721-x6f26ahr 4140 9 protein protein NN cord-028721-x6f26ahr 4140 10 ( ( -LRB- cord-028721-x6f26ahr 4140 11 StAR StAR NNP cord-028721-x6f26ahr 4140 12 ) ) -RRB- cord-028721-x6f26ahr 4140 13 in in IN cord-028721-x6f26ahr 4140 14 six six CD cord-028721-x6f26ahr 4140 15 patients patient NNS cord-028721-x6f26ahr 4140 16 with with IN cord-028721-x6f26ahr 4140 17 congenital congenital JJ cord-028721-x6f26ahr 4140 18 lipoid lipoid JJ cord-028721-x6f26ahr 4140 19 adrenal adrenal JJ cord-028721-x6f26ahr 4140 20 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4140 21 Disorders disorder NNS cord-028721-x6f26ahr 4140 22 of of IN cord-028721-x6f26ahr 4140 23 androgen androgen NN cord-028721-x6f26ahr 4140 24 synthesis synthesis NN cord-028721-x6f26ahr 4141 1 -from -from JJ cord-028721-x6f26ahr 4142 1 cholesterol cholesterol NN cord-028721-x6f26ahr 4142 2 to to IN cord-028721-x6f26ahr 4142 3 dehydroepiandrosterone dehydroepiandrosterone NNP cord-028721-x6f26ahr 4142 4 A a DT cord-028721-x6f26ahr 4142 5 genetic genetic JJ cord-028721-x6f26ahr 4142 6 isolate isolate NN cord-028721-x6f26ahr 4142 7 of of IN cord-028721-x6f26ahr 4142 8 congenital congenital JJ cord-028721-x6f26ahr 4142 9 lipoid lipoid JJ cord-028721-x6f26ahr 4142 10 adrenal adrenal JJ cord-028721-x6f26ahr 4142 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4142 12 with with IN cord-028721-x6f26ahr 4142 13 atypical atypical JJ cord-028721-x6f26ahr 4142 14 clinical clinical JJ cord-028721-x6f26ahr 4142 15 fi fi NN cord-028721-x6f26ahr 4142 16 ndings nding NNS cord-028721-x6f26ahr 4143 1 Phenotypic phenotypic JJ cord-028721-x6f26ahr 4143 2 variations variation NNS cord-028721-x6f26ahr 4143 3 in in IN cord-028721-x6f26ahr 4143 4 lipoid lipoid JJ cord-028721-x6f26ahr 4143 5 congenital congenital JJ cord-028721-x6f26ahr 4143 6 adrenal adrenal JJ cord-028721-x6f26ahr 4143 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4144 1 Abnormal abnormal JJ cord-028721-x6f26ahr 4144 2 sex sex NN cord-028721-x6f26ahr 4144 3 differentiation differentiation NN cord-028721-x6f26ahr 4145 1 Prenatal prenatal JJ cord-028721-x6f26ahr 4145 2 diagnosis diagnosis NN cord-028721-x6f26ahr 4145 3 of of IN cord-028721-x6f26ahr 4145 4 congenital congenital JJ cord-028721-x6f26ahr 4145 5 lipoid lipoid JJ cord-028721-x6f26ahr 4145 6 adrenal adrenal JJ cord-028721-x6f26ahr 4145 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4145 8 Targeted target VBN cord-028721-x6f26ahr 4145 9 disruption disruption NN cord-028721-x6f26ahr 4145 10 of of IN cord-028721-x6f26ahr 4145 11 the the DT cord-028721-x6f26ahr 4145 12 mouse mouse NN cord-028721-x6f26ahr 4145 13 gene gene NN cord-028721-x6f26ahr 4145 14 encoding encoding NN cord-028721-x6f26ahr 4146 1 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4146 2 acute acute JJ cord-028721-x6f26ahr 4146 3 regulatory regulatory JJ cord-028721-x6f26ahr 4146 4 protein protein NN cord-028721-x6f26ahr 4146 5 provides provide VBZ cord-028721-x6f26ahr 4146 6 insights insight NNS cord-028721-x6f26ahr 4146 7 into into IN cord-028721-x6f26ahr 4146 8 congenital congenital JJ cord-028721-x6f26ahr 4146 9 lipoid lipoid JJ cord-028721-x6f26ahr 4146 10 adrenal adrenal JJ cord-028721-x6f26ahr 4146 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4147 1 An an DT cord-028721-x6f26ahr 4147 2 autopsy autopsy JJ cord-028721-x6f26ahr 4147 3 case case NN cord-028721-x6f26ahr 4147 4 of of IN cord-028721-x6f26ahr 4147 5 congenital congenital JJ cord-028721-x6f26ahr 4147 6 lipoid lipoid NNP cord-028721-x6f26ahr 4147 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4147 8 of of IN cord-028721-x6f26ahr 4147 9 the the DT cord-028721-x6f26ahr 4147 10 adrenal adrenal JJ cord-028721-x6f26ahr 4147 11 cortex cortex NNP cord-028721-x6f26ahr 4147 12 Gonadal Gonadal NNP cord-028721-x6f26ahr 4147 13 development development NN cord-028721-x6f26ahr 4147 14 and and CC cord-028721-x6f26ahr 4147 15 grown grow VBN cord-028721-x6f26ahr 4147 16 in in IN cord-028721-x6f26ahr 4147 17 46,XX 46,xx CD cord-028721-x6f26ahr 4147 18 and and CC cord-028721-x6f26ahr 4147 19 46,XY 46,xy CD cord-028721-x6f26ahr 4147 20 individuals individual NNS cord-028721-x6f26ahr 4147 21 with with IN cord-028721-x6f26ahr 4147 22 P450scc p450scc PRP$ cord-028721-x6f26ahr 4147 23 defi defi FW cord-028721-x6f26ahr 4147 24 ciency ciency NNP cord-028721-x6f26ahr 4147 25 ( ( -LRB- cord-028721-x6f26ahr 4147 26 congenital congenital JJ cord-028721-x6f26ahr 4147 27 lipoid lipoid NNP cord-028721-x6f26ahr 4147 28 adrenal adrenal JJ cord-028721-x6f26ahr 4147 29 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4147 30 ) ) -RRB- cord-028721-x6f26ahr 4148 1 New new JJ cord-028721-x6f26ahr 4148 2 developments development NNS cord-028721-x6f26ahr 4148 3 in in IN cord-028721-x6f26ahr 4148 4 congenital congenital JJ cord-028721-x6f26ahr 4148 5 lipoid lipoid JJ cord-028721-x6f26ahr 4148 6 adrenal adrenal JJ cord-028721-x6f26ahr 4148 7 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4148 8 and and CC cord-028721-x6f26ahr 4148 9 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4148 10 acute acute JJ cord-028721-x6f26ahr 4148 11 regulatory regulatory JJ cord-028721-x6f26ahr 4148 12 protein protein NN cord-028721-x6f26ahr 4148 13 Zur Zur NNP cord-028721-x6f26ahr 4148 14 Morphologie Morphologie NNP cord-028721-x6f26ahr 4149 1 und und NNP cord-028721-x6f26ahr 4150 1 Genese Genese NNP cord-028721-x6f26ahr 4150 2 der der VBP cord-028721-x6f26ahr 4150 3 kongenitalen kongenitalen NNP cord-028721-x6f26ahr 4151 1 Nebennierenrindenhyperplasie Nebennierenrindenhyperplasie NNP cord-028721-x6f26ahr 4151 2 beim beim NNP cord-028721-x6f26ahr 4152 1 männlichen männlichen NNP cord-028721-x6f26ahr 4152 2 scheinzwitter scheinzwitter NNP cord-028721-x6f26ahr 4153 1 The the DT cord-028721-x6f26ahr 4153 2 testicular testicular JJ cord-028721-x6f26ahr 4153 3 lesion lesion NN cord-028721-x6f26ahr 4153 4 and and CC cord-028721-x6f26ahr 4153 5 sexual sexual JJ cord-028721-x6f26ahr 4153 6 differentiation differentiation NN cord-028721-x6f26ahr 4153 7 in in IN cord-028721-x6f26ahr 4153 8 congenital congenital JJ cord-028721-x6f26ahr 4153 9 lipoid lipoid JJ cord-028721-x6f26ahr 4153 10 adrenal adrenal JJ cord-028721-x6f26ahr 4153 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 1 Congenital congenital JJ cord-028721-x6f26ahr 4154 2 adrenal adrenal JJ cord-028721-x6f26ahr 4154 3 lipoid lipoid NN cord-028721-x6f26ahr 4154 4 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 5 due due IN cord-028721-x6f26ahr 4154 6 to to IN cord-028721-x6f26ahr 4154 7 defi defi NNP cord-028721-x6f26ahr 4154 8 cient cient NNP cord-028721-x6f26ahr 4154 9 cholesterol cholesterol NNP cord-028721-x6f26ahr 4154 10 side side NN cord-028721-x6f26ahr 4154 11 - - HYPH cord-028721-x6f26ahr 4154 12 chain chain NN cord-028721-x6f26ahr 4154 13 cleavage cleavage NN cord-028721-x6f26ahr 4154 14 activity activity NN cord-028721-x6f26ahr 4154 15 ( ( -LRB- cord-028721-x6f26ahr 4154 16 20,22-desmolase 20,22-desmolase NNP cord-028721-x6f26ahr 4154 17 ) ) -RRB- cord-028721-x6f26ahr 4154 18 in in IN cord-028721-x6f26ahr 4154 19 a a DT cord-028721-x6f26ahr 4154 20 patient patient NN cord-028721-x6f26ahr 4154 21 treated treat VBN cord-028721-x6f26ahr 4154 22 for for IN cord-028721-x6f26ahr 4154 23 18 18 CD cord-028721-x6f26ahr 4154 24 years year NNS cord-028721-x6f26ahr 4154 25 Congenital congenital JJ cord-028721-x6f26ahr 4154 26 lipoid lipoid NN cord-028721-x6f26ahr 4154 27 adrenal adrenal JJ cord-028721-x6f26ahr 4154 28 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 29 in in IN cord-028721-x6f26ahr 4154 30 a a DT cord-028721-x6f26ahr 4154 31 eight eight CD cord-028721-x6f26ahr 4154 32 - - HYPH cord-028721-x6f26ahr 4154 33 year year NN cord-028721-x6f26ahr 4154 34 - - HYPH cord-028721-x6f26ahr 4154 35 old old JJ cord-028721-x6f26ahr 4154 36 phenotype phenotype NN cord-028721-x6f26ahr 4154 37 female female NN cord-028721-x6f26ahr 4154 38 Gonadal Gonadal NNP cord-028721-x6f26ahr 4154 39 histology histology NN cord-028721-x6f26ahr 4154 40 with with IN cord-028721-x6f26ahr 4154 41 testicular testicular JJ cord-028721-x6f26ahr 4154 42 carcinoma carcinoma NN cord-028721-x6f26ahr 4154 43 in in IN cord-028721-x6f26ahr 4154 44 situ situ NN cord-028721-x6f26ahr 4154 45 in in IN cord-028721-x6f26ahr 4154 46 a a DT cord-028721-x6f26ahr 4154 47 15-year 15-year JJ cord-028721-x6f26ahr 4154 48 old old JJ cord-028721-x6f26ahr 4154 49 46,XY 46,xy CD cord-028721-x6f26ahr 4154 50 female female JJ cord-028721-x6f26ahr 4154 51 patient patient NN cord-028721-x6f26ahr 4154 52 with with IN cord-028721-x6f26ahr 4154 53 a a DT cord-028721-x6f26ahr 4154 54 premature premature JJ cord-028721-x6f26ahr 4154 55 termination termination NN cord-028721-x6f26ahr 4154 56 in in IN cord-028721-x6f26ahr 4154 57 the the DT cord-028721-x6f26ahr 4154 58 steroidogenic steroidogenic NNP cord-028721-x6f26ahr 4154 59 acute acute JJ cord-028721-x6f26ahr 4154 60 regulatory regulatory JJ cord-028721-x6f26ahr 4154 61 protein protein NN cord-028721-x6f26ahr 4154 62 causing cause VBG cord-028721-x6f26ahr 4154 63 congenital congenital JJ cord-028721-x6f26ahr 4154 64 lipoid lipoid JJ cord-028721-x6f26ahr 4154 65 adrenal adrenal JJ cord-028721-x6f26ahr 4154 66 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 67 Unusual unusual JJ cord-028721-x6f26ahr 4154 68 steroid steroid NN cord-028721-x6f26ahr 4154 69 pattern pattern NN cord-028721-x6f26ahr 4154 70 in in IN cord-028721-x6f26ahr 4154 71 congenital congenital JJ cord-028721-x6f26ahr 4154 72 adrenal adrenal JJ cord-028721-x6f26ahr 4154 73 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 74 : : : cord-028721-x6f26ahr 4154 75 defi defi NNP cord-028721-x6f26ahr 4154 76 ciency ciency NNP cord-028721-x6f26ahr 4154 77 of of IN cord-028721-x6f26ahr 4154 78 3β 3β CD cord-028721-x6f26ahr 4154 79 - - HYPH cord-028721-x6f26ahr 4154 80 hydroxydehydrogenase hydroxydehydrogenase NNP cord-028721-x6f26ahr 4154 81 Pubertal Pubertal NNP cord-028721-x6f26ahr 4154 82 boy boy NN cord-028721-x6f26ahr 4154 83 with with IN cord-028721-x6f26ahr 4154 84 the the DT cord-028721-x6f26ahr 4154 85 3β 3β CD cord-028721-x6f26ahr 4154 86 - - HYPH cord-028721-x6f26ahr 4154 87 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4154 88 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4154 89 defect defect NN cord-028721-x6f26ahr 4154 90 Characterization characterization NN cord-028721-x6f26ahr 4154 91 of of IN cord-028721-x6f26ahr 4154 92 two two CD cord-028721-x6f26ahr 4154 93 novel novel JJ cord-028721-x6f26ahr 4154 94 homozygous homozygous JJ cord-028721-x6f26ahr 4154 95 missense missense NN cord-028721-x6f26ahr 4154 96 mutations mutation NNS cord-028721-x6f26ahr 4154 97 involving involve VBG cord-028721-x6f26ahr 4154 98 codon codon NN cord-028721-x6f26ahr 4154 99 6 6 CD cord-028721-x6f26ahr 4154 100 and and CC cord-028721-x6f26ahr 4154 101 259 259 CD cord-028721-x6f26ahr 4154 102 of of IN cord-028721-x6f26ahr 4154 103 type type NN cord-028721-x6f26ahr 4154 104 II II NNP cord-028721-x6f26ahr 4154 105 3β 3β NN cord-028721-x6f26ahr 4154 106 - - HYPH cord-028721-x6f26ahr 4154 107 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4154 108 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4154 109 ( ( -LRB- cord-028721-x6f26ahr 4154 110 3βHSD 3βHSD NNP cord-028721-x6f26ahr 4154 111 ) ) -RRB- cord-028721-x6f26ahr 4154 112 gene gene NN cord-028721-x6f26ahr 4154 113 causing cause VBG cord-028721-x6f26ahr 4154 114 , , , cord-028721-x6f26ahr 4154 115 respectively respectively RB cord-028721-x6f26ahr 4154 116 , , , cord-028721-x6f26ahr 4154 117 nonsalt nonsalt NN cord-028721-x6f26ahr 4154 118 - - HYPH cord-028721-x6f26ahr 4154 119 wasting waste VBG cord-028721-x6f26ahr 4154 120 and and CC cord-028721-x6f26ahr 4154 121 salt salt NN cord-028721-x6f26ahr 4154 122 - - HYPH cord-028721-x6f26ahr 4154 123 wasting waste VBG cord-028721-x6f26ahr 4154 124 3βHSD 3βhsd CD cord-028721-x6f26ahr 4154 125 defi defi NNP cord-028721-x6f26ahr 4154 126 ciency ciency NNP cord-028721-x6f26ahr 4154 127 disorder disorder NN cord-028721-x6f26ahr 4154 128 Disorders disorder NNS cord-028721-x6f26ahr 4154 129 of of IN cord-028721-x6f26ahr 4154 130 sexual sexual JJ cord-028721-x6f26ahr 4154 131 differentiation differentiation NN cord-028721-x6f26ahr 4154 132 Congenital congenital JJ cord-028721-x6f26ahr 4154 133 adrenal adrenal JJ cord-028721-x6f26ahr 4154 134 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 135 due due IN cord-028721-x6f26ahr 4154 136 to to IN cord-028721-x6f26ahr 4154 137 point point NN cord-028721-x6f26ahr 4154 138 mutations mutation NNS cord-028721-x6f26ahr 4154 139 in in IN cord-028721-x6f26ahr 4154 140 the the DT cord-028721-x6f26ahr 4154 141 type type NN cord-028721-x6f26ahr 4154 142 II II NNP cord-028721-x6f26ahr 4154 143 3β 3β NN cord-028721-x6f26ahr 4154 144 - - HYPH cord-028721-x6f26ahr 4154 145 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4154 146 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4154 147 gene gene NN cord-028721-x6f26ahr 4154 148 Molecular molecular JJ cord-028721-x6f26ahr 4154 149 basis basis NN cord-028721-x6f26ahr 4154 150 of of IN cord-028721-x6f26ahr 4154 151 congenital congenital JJ cord-028721-x6f26ahr 4154 152 adrenal adrenal JJ cord-028721-x6f26ahr 4154 153 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4154 154 due due IN cord-028721-x6f26ahr 4154 155 to to IN cord-028721-x6f26ahr 4154 156 3β 3β CD cord-028721-x6f26ahr 4154 157 - - HYPH cord-028721-x6f26ahr 4154 158 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4154 159 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4154 160 defi defi XX cord-028721-x6f26ahr 4154 161 ciency ciency NNP cord-028721-x6f26ahr 4154 162 Detection Detection NNP cord-028721-x6f26ahr 4154 163 and and CC cord-028721-x6f26ahr 4154 164 functional functional JJ cord-028721-x6f26ahr 4154 165 characterization characterization NN cord-028721-x6f26ahr 4154 166 of of IN cord-028721-x6f26ahr 4154 167 the the DT cord-028721-x6f26ahr 4154 168 novel novel JJ cord-028721-x6f26ahr 4154 169 missense missense NN cord-028721-x6f26ahr 4154 170 mutation mutation NN cord-028721-x6f26ahr 4154 171 Y254D Y254D NNP cord-028721-x6f26ahr 4154 172 in in IN cord-028721-x6f26ahr 4154 173 type type NN cord-028721-x6f26ahr 4154 174 II II NNP cord-028721-x6f26ahr 4155 1 3β 3β CD cord-028721-x6f26ahr 4155 2 - - HYPH cord-028721-x6f26ahr 4155 3 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4155 4 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4155 5 ( ( -LRB- cord-028721-x6f26ahr 4155 6 3βHSD 3βHSD NNP cord-028721-x6f26ahr 4155 7 ) ) -RRB- cord-028721-x6f26ahr 4155 8 gene gene NN cord-028721-x6f26ahr 4155 9 of of IN cord-028721-x6f26ahr 4155 10 a a DT cord-028721-x6f26ahr 4155 11 female female JJ cord-028721-x6f26ahr 4155 12 patient patient NN cord-028721-x6f26ahr 4155 13 with with IN cord-028721-x6f26ahr 4155 14 nonsalt nonsalt RB cord-028721-x6f26ahr 4155 15 - - HYPH cord-028721-x6f26ahr 4155 16 losing lose VBG cord-028721-x6f26ahr 4155 17 3βHSD 3βhsd CD cord-028721-x6f26ahr 4155 18 defi defi NNP cord-028721-x6f26ahr 4155 19 ciency ciency NNP cord-028721-x6f26ahr 4155 20 Nonsalt Nonsalt NNP cord-028721-x6f26ahr 4155 21 - - HYPH cord-028721-x6f26ahr 4155 22 losing lose VBG cord-028721-x6f26ahr 4155 23 congenital congenital JJ cord-028721-x6f26ahr 4155 24 adrenal adrenal JJ cord-028721-x6f26ahr 4155 25 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4155 26 due due IN cord-028721-x6f26ahr 4155 27 to to IN cord-028721-x6f26ahr 4155 28 3β 3β CD cord-028721-x6f26ahr 4155 29 - - HYPH cord-028721-x6f26ahr 4155 30 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4155 31 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4155 32 defi defi NN cord-028721-x6f26ahr 4155 33 ciency ciency NN cord-028721-x6f26ahr 4155 34 with with IN cord-028721-x6f26ahr 4155 35 normal normal JJ cord-028721-x6f26ahr 4155 36 glomerulosa glomerulosa JJ cord-028721-x6f26ahr 4155 37 function function NN cord-028721-x6f26ahr 4155 38 Defects defect NNS cord-028721-x6f26ahr 4155 39 of of IN cord-028721-x6f26ahr 4155 40 the the DT cord-028721-x6f26ahr 4155 41 testosterone testosterone NN cord-028721-x6f26ahr 4155 42 biosynthetic biosynthetic JJ cord-028721-x6f26ahr 4155 43 pathway pathway NN cord-028721-x6f26ahr 4155 44 in in IN cord-028721-x6f26ahr 4155 45 boys boy NNS cord-028721-x6f26ahr 4155 46 with with IN cord-028721-x6f26ahr 4155 47 hypospadias hypospadia NNS cord-028721-x6f26ahr 4155 48 Abnormalities abnormality NNS cord-028721-x6f26ahr 4155 49 of of IN cord-028721-x6f26ahr 4155 50 adrenal adrenal JJ cord-028721-x6f26ahr 4155 51 steroidogenesis steroidogenesis NN cord-028721-x6f26ahr 4155 52 in in IN cord-028721-x6f26ahr 4155 53 Chilean chilean JJ cord-028721-x6f26ahr 4155 54 boys boy NNS cord-028721-x6f26ahr 4155 55 with with IN cord-028721-x6f26ahr 4155 56 micropenis micropenis NNP cord-028721-x6f26ahr 4155 57 Mutation Mutation NNP cord-028721-x6f26ahr 4155 58 of of IN cord-028721-x6f26ahr 4155 59 proline proline NNP cord-028721-x6f26ahr 4155 60 409 409 CD cord-028721-x6f26ahr 4155 61 to to IN cord-028721-x6f26ahr 4155 62 arginine arginine NN cord-028721-x6f26ahr 4155 63 in in IN cord-028721-x6f26ahr 4155 64 the the DT cord-028721-x6f26ahr 4155 65 meander meander NN cord-028721-x6f26ahr 4155 66 region region NN cord-028721-x6f26ahr 4155 67 of of IN cord-028721-x6f26ahr 4155 68 cytochrome cytochrome NN cord-028721-x6f26ahr 4156 1 p450c17 p450c17 `` cord-028721-x6f26ahr 4156 2 causes cause NNS cord-028721-x6f26ahr 4156 3 severe severe JJ cord-028721-x6f26ahr 4156 4 17 17 CD cord-028721-x6f26ahr 4156 5 alpha alpha NN cord-028721-x6f26ahr 4156 6 - - HYPH cord-028721-x6f26ahr 4156 7 hydroxylase hydroxylase NN cord-028721-x6f26ahr 4156 8 defi defi NN cord-028721-x6f26ahr 4157 1 ciency ciency NNP cord-028721-x6f26ahr 4157 2 Localization Localization NNP cord-028721-x6f26ahr 4157 3 of of IN cord-028721-x6f26ahr 4157 4 the the DT cord-028721-x6f26ahr 4157 5 human human JJ cord-028721-x6f26ahr 4157 6 CYP17 CYP17 NNP cord-028721-x6f26ahr 4157 7 gene gene NN cord-028721-x6f26ahr 4157 8 ( ( -LRB- cord-028721-x6f26ahr 4157 9 cytochrome cytochrome NN cord-028721-x6f26ahr 4157 10 P450 P450 NNPS cord-028721-x6f26ahr 4157 11 ( ( -LRB- cord-028721-x6f26ahr 4157 12 17 17 CD cord-028721-x6f26ahr 4157 13 alpha alpha NN cord-028721-x6f26ahr 4157 14 ) ) -RRB- cord-028721-x6f26ahr 4157 15 ) ) -RRB- cord-028721-x6f26ahr 4157 16 to to IN cord-028721-x6f26ahr 4157 17 10q24.3 10q24.3 CD cord-028721-x6f26ahr 4157 18 by by IN cord-028721-x6f26ahr 4157 19 fl fl NNP cord-028721-x6f26ahr 4157 20 uorescence uorescence NNP cord-028721-x6f26ahr 4157 21 ' ' '' cord-028721-x6f26ahr 4157 22 in in IN cord-028721-x6f26ahr 4157 23 situ situ NN cord-028721-x6f26ahr 4157 24 ' ' '' cord-028721-x6f26ahr 4157 25 hybridization hybridization NN cord-028721-x6f26ahr 4157 26 and and CC cord-028721-x6f26ahr 4157 27 simultaneous simultaneous JJ cord-028721-x6f26ahr 4158 1 chromosome chromosome NN cord-028721-x6f26ahr 4158 2 banding band VBG cord-028721-x6f26ahr 4158 3 A a DT cord-028721-x6f26ahr 4158 4 novel novel JJ cord-028721-x6f26ahr 4158 5 point point NN cord-028721-x6f26ahr 4158 6 mutation mutation NN cord-028721-x6f26ahr 4158 7 in in IN cord-028721-x6f26ahr 4158 8 P450c17 p450c17 NN cord-028721-x6f26ahr 4158 9 ( ( -LRB- cord-028721-x6f26ahr 4158 10 CYP17 cyp17 NN cord-028721-x6f26ahr 4158 11 ) ) -RRB- cord-028721-x6f26ahr 4159 1 causing cause VBG cord-028721-x6f26ahr 4159 2 combined combined JJ cord-028721-x6f26ahr 4159 3 17alpha 17alpha CD cord-028721-x6f26ahr 4159 4 - - HYPH cord-028721-x6f26ahr 4159 5 hydroxylase/17,20-lyase hydroxylase/17,20-lyase NN cord-028721-x6f26ahr 4159 6 defi defi NN cord-028721-x6f26ahr 4159 7 ciency ciency NNP cord-028721-x6f26ahr 4159 8 Towards towards IN cord-028721-x6f26ahr 4159 9 a a DT cord-028721-x6f26ahr 4159 10 unifying unifying JJ cord-028721-x6f26ahr 4159 11 mechanism mechanism NN cord-028721-x6f26ahr 4159 12 for for IN cord-028721-x6f26ahr 4159 13 CYP17 CYP17 NNP cord-028721-x6f26ahr 4159 14 mutations mutation NNS cord-028721-x6f26ahr 4159 15 that that WDT cord-028721-x6f26ahr 4159 16 cause cause VBP cord-028721-x6f26ahr 4159 17 isolated isolate VBN cord-028721-x6f26ahr 4159 18 17,20-lyase 17,20-lyase NNP cord-028721-x6f26ahr 4159 19 defi defi NNP cord-028721-x6f26ahr 4159 20 ciency ciency NNP cord-028721-x6f26ahr 4159 21 17 17 CD cord-028721-x6f26ahr 4159 22 alpha alpha NN cord-028721-x6f26ahr 4159 23 - - HYPH cord-028721-x6f26ahr 4159 24 hydroxylation hydroxylation NN cord-028721-x6f26ahr 4159 25 defi defi NN cord-028721-x6f26ahr 4159 26 ciency ciency NNP cord-028721-x6f26ahr 4159 27 in in IN cord-028721-x6f26ahr 4159 28 man man NN cord-028721-x6f26ahr 4159 29 Endocrine endocrine JJ cord-028721-x6f26ahr 4159 30 studies study NNS cord-028721-x6f26ahr 4159 31 in in IN cord-028721-x6f26ahr 4159 32 male male JJ cord-028721-x6f26ahr 4159 33 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4159 34 in in IN cord-028721-x6f26ahr 4159 35 childhood childhood NN cord-028721-x6f26ahr 4159 36 and and CC cord-028721-x6f26ahr 4159 37 adolescence adolescence NN cord-028721-x6f26ahr 4160 1 desmolase desmolase NNP cord-028721-x6f26ahr 4160 2 defi defi NNP cord-028721-x6f26ahr 4160 3 ciency ciency NNP cord-028721-x6f26ahr 4161 1 Male male JJ cord-028721-x6f26ahr 4161 2 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4161 3 consistent consistent JJ cord-028721-x6f26ahr 4161 4 with with IN cord-028721-x6f26ahr 4161 5 17 17 CD cord-028721-x6f26ahr 4161 6 - - SYM cord-028721-x6f26ahr 4161 7 20 20 CD cord-028721-x6f26ahr 4161 8 desmolase desmolase NN cord-028721-x6f26ahr 4161 9 defi defi NNP cord-028721-x6f26ahr 4161 10 ciency ciency NNP cord-028721-x6f26ahr 4161 11 Pitfalls Pitfalls NNPS cord-028721-x6f26ahr 4161 12 in in IN cord-028721-x6f26ahr 4161 13 characterizing characterize VBG cord-028721-x6f26ahr 4161 14 P450c17 p450c17 JJ cord-028721-x6f26ahr 4161 15 mutations mutation NNS cord-028721-x6f26ahr 4161 16 associated associate VBN cord-028721-x6f26ahr 4161 17 with with IN cord-028721-x6f26ahr 4161 18 isolated isolate VBN cord-028721-x6f26ahr 4161 19 17,20-lyase 17,20-lyase CD cord-028721-x6f26ahr 4161 20 defi defi NNP cord-028721-x6f26ahr 4161 21 ciency ciency NNP cord-028721-x6f26ahr 4161 22 Severe Severe NNP cord-028721-x6f26ahr 4161 23 46,XY 46,xy CD cord-028721-x6f26ahr 4161 24 virilization virilization NN cord-028721-x6f26ahr 4161 25 defi defi NNP cord-028721-x6f26ahr 4161 26 cit cit NNP cord-028721-x6f26ahr 4161 27 due due IN cord-028721-x6f26ahr 4161 28 to to IN cord-028721-x6f26ahr 4161 29 17β 17β NNS cord-028721-x6f26ahr 4161 30 - - HYPH cord-028721-x6f26ahr 4161 31 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4161 32 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4161 33 defi defi NN cord-028721-x6f26ahr 4161 34 ciency ciency NNP cord-028721-x6f26ahr 4162 1 17 17 CD cord-028721-x6f26ahr 4162 2 ketosteroid ketosteroid NNP cord-028721-x6f26ahr 4162 3 reductase reductase NNP cord-028721-x6f26ahr 4162 4 defi defi NNP cord-028721-x6f26ahr 4162 5 ciency ciency NN cord-028721-x6f26ahr 4162 6 in in IN cord-028721-x6f26ahr 4162 7 an an DT cord-028721-x6f26ahr 4162 8 adult adult NN cord-028721-x6f26ahr 4162 9 patient patient NN cord-028721-x6f26ahr 4162 10 without without IN cord-028721-x6f26ahr 4162 11 gynecomastia gynecomastia NN cord-028721-x6f26ahr 4162 12 but but CC cord-028721-x6f26ahr 4162 13 with with IN cord-028721-x6f26ahr 4162 14 female female JJ cord-028721-x6f26ahr 4162 15 psychosexual psychosexual JJ cord-028721-x6f26ahr 4162 16 orientation orientation NN cord-028721-x6f26ahr 4162 17 Absent Absent NNP cord-028721-x6f26ahr 4162 18 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4162 19 despite despite IN cord-028721-x6f26ahr 4162 20 early early JJ cord-028721-x6f26ahr 4162 21 bilateral bilateral JJ cord-028721-x6f26ahr 4162 22 orchidopexy orchidopexy NN cord-028721-x6f26ahr 4162 23 in in IN cord-028721-x6f26ahr 4162 24 17-ketoreductase 17-ketoreductase CD cord-028721-x6f26ahr 4162 25 defi defi NNP cord-028721-x6f26ahr 4162 26 ciency ciency NNP cord-028721-x6f26ahr 4162 27 Substitution Substitution NNP cord-028721-x6f26ahr 4162 28 mutation mutation NN cord-028721-x6f26ahr 4162 29 C268Y C268Y NNP cord-028721-x6f26ahr 4162 30 causes cause VBZ cord-028721-x6f26ahr 4162 31 17β 17β NNS cord-028721-x6f26ahr 4162 32 - - HYPH cord-028721-x6f26ahr 4162 33 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4162 34 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4162 35 3 3 CD cord-028721-x6f26ahr 4162 36 defi defi NNP cord-028721-x6f26ahr 4162 37 ciency ciency NNP cord-028721-x6f26ahr 4162 38 Novel Novel NNP cord-028721-x6f26ahr 4162 39 insertion insertion NN cord-028721-x6f26ahr 4162 40 frameshift frameshift NN cord-028721-x6f26ahr 4162 41 mutation mutation NN cord-028721-x6f26ahr 4162 42 of of IN cord-028721-x6f26ahr 4162 43 the the DT cord-028721-x6f26ahr 4162 44 LH LH NNP cord-028721-x6f26ahr 4162 45 receptor receptor NN cord-028721-x6f26ahr 4162 46 gene gene NN cord-028721-x6f26ahr 4162 47 : : : cord-028721-x6f26ahr 4162 48 problematic problematic JJ cord-028721-x6f26ahr 4162 49 clinical clinical JJ cord-028721-x6f26ahr 4162 50 distinction distinction NN cord-028721-x6f26ahr 4162 51 of of IN cord-028721-x6f26ahr 4162 52 Leydig Leydig NNP cord-028721-x6f26ahr 4162 53 cell cell NN cord-028721-x6f26ahr 4162 54 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4162 55 from from IN cord-028721-x6f26ahr 4162 56 enzyme enzyme NN cord-028721-x6f26ahr 4162 57 defects defect NNS cord-028721-x6f26ahr 4162 58 primarily primarily RB cord-028721-x6f26ahr 4162 59 affecting affect VBG cord-028721-x6f26ahr 4162 60 testosterone testosterone NN cord-028721-x6f26ahr 4162 61 biosynthesis biosynthesis NN cord-028721-x6f26ahr 4162 62 Leydig Leydig NNP cord-028721-x6f26ahr 4162 63 cell cell NN cord-028721-x6f26ahr 4162 64 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4162 65 : : : cord-028721-x6f26ahr 4163 1 A a DT cord-028721-x6f26ahr 4163 2 cause cause NN cord-028721-x6f26ahr 4163 3 of of IN cord-028721-x6f26ahr 4163 4 male male JJ cord-028721-x6f26ahr 4163 5 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4163 6 Leydig Leydig NNP cord-028721-x6f26ahr 4163 7 cell cell NN cord-028721-x6f26ahr 4163 8 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4163 9 causing cause VBG cord-028721-x6f26ahr 4163 10 male male JJ cord-028721-x6f26ahr 4163 11 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4163 12 : : : cord-028721-x6f26ahr 4163 13 diagnosis diagnosis NN cord-028721-x6f26ahr 4163 14 13 13 CD cord-028721-x6f26ahr 4163 15 year year NN cord-028721-x6f26ahr 4163 16 after after IN cord-028721-x6f26ahr 4163 17 prepubertal prepubertal JJ cord-028721-x6f26ahr 4163 18 castration castration NN cord-028721-x6f26ahr 4163 19 Leydig Leydig NNP cord-028721-x6f26ahr 4163 20 cell cell NN cord-028721-x6f26ahr 4163 21 hypofunction hypofunction NN cord-028721-x6f26ahr 4163 22 resulting result VBG cord-028721-x6f26ahr 4163 23 in in IN cord-028721-x6f26ahr 4163 24 male male JJ cord-028721-x6f26ahr 4163 25 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4163 26 A a DT cord-028721-x6f26ahr 4163 27 case case NN cord-028721-x6f26ahr 4163 28 of of IN cord-028721-x6f26ahr 4163 29 male male JJ cord-028721-x6f26ahr 4163 30 pseudohemaphroditism pseudohemaphroditism NN cord-028721-x6f26ahr 4163 31 associated associate VBN cord-028721-x6f26ahr 4163 32 with with IN cord-028721-x6f26ahr 4163 33 elevated elevated JJ cord-028721-x6f26ahr 4163 34 LH lh NN cord-028721-x6f26ahr 4163 35 , , , cord-028721-x6f26ahr 4163 36 normal normal JJ cord-028721-x6f26ahr 4163 37 FSH fsh NN cord-028721-x6f26ahr 4163 38 and and CC cord-028721-x6f26ahr 4163 39 low low JJ cord-028721-x6f26ahr 4163 40 testosterone testosterone NN cord-028721-x6f26ahr 4163 41 possibly possibly RB cord-028721-x6f26ahr 4163 42 due due IN cord-028721-x6f26ahr 4163 43 to to IN cord-028721-x6f26ahr 4163 44 the the DT cord-028721-x6f26ahr 4163 45 secretion secretion NN cord-028721-x6f26ahr 4163 46 of of IN cord-028721-x6f26ahr 4163 47 an an DT cord-028721-x6f26ahr 4163 48 abnormal abnormal JJ cord-028721-x6f26ahr 4163 49 LH lh NN cord-028721-x6f26ahr 4163 50 molecula molecula NNP cord-028721-x6f26ahr 4163 51 Inherited inherit VBN cord-028721-x6f26ahr 4163 52 male male JJ cord-028721-x6f26ahr 4163 53 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4163 54 due due JJ cord-028721-x6f26ahr 4163 55 to to IN cord-028721-x6f26ahr 4163 56 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4163 57 irresponsiveness irresponsiveness NN cord-028721-x6f26ahr 4164 1 A a DT cord-028721-x6f26ahr 4164 2 clinico clinico NN cord-028721-x6f26ahr 4164 3 - - HYPH cord-028721-x6f26ahr 4164 4 genetic genetic JJ cord-028721-x6f26ahr 4164 5 investigation investigation NN cord-028721-x6f26ahr 4164 6 of of IN cord-028721-x6f26ahr 4164 7 Leydig Leydig NNP cord-028721-x6f26ahr 4164 8 cell cell NN cord-028721-x6f26ahr 4164 9 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4164 10 Naturally naturally RB cord-028721-x6f26ahr 4164 11 occurring occur VBG cord-028721-x6f26ahr 4164 12 mutations mutation NNS cord-028721-x6f26ahr 4164 13 of of IN cord-028721-x6f26ahr 4164 14 the the DT cord-028721-x6f26ahr 4164 15 luteinizing luteinize VBG cord-028721-x6f26ahr 4164 16 hormone hormone NN cord-028721-x6f26ahr 4164 17 receptor receptor NN cord-028721-x6f26ahr 4164 18 gene gene NN cord-028721-x6f26ahr 4164 19 affecting affect VBG cord-028721-x6f26ahr 4164 20 reproduction reproduction NN cord-028721-x6f26ahr 4164 21 Leydig Leydig NNP cord-028721-x6f26ahr 4164 22 cell cell NN cord-028721-x6f26ahr 4164 23 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4164 24 due due IN cord-028721-x6f26ahr 4164 25 to to IN cord-028721-x6f26ahr 4164 26 inactivation inactivation NN cord-028721-x6f26ahr 4164 27 of of IN cord-028721-x6f26ahr 4164 28 luteinizing luteinize VBG cord-028721-x6f26ahr 4164 29 hormone hormone NN cord-028721-x6f26ahr 4164 30 receptor receptor NN cord-028721-x6f26ahr 4164 31 by by IN cord-028721-x6f26ahr 4164 32 a a DT cord-028721-x6f26ahr 4164 33 novel novel JJ cord-028721-x6f26ahr 4164 34 homozygous homozygous JJ cord-028721-x6f26ahr 4164 35 nonsense nonsense NN cord-028721-x6f26ahr 4164 36 truncation truncation NN cord-028721-x6f26ahr 4164 37 mutation mutation NN cord-028721-x6f26ahr 4164 38 in in IN cord-028721-x6f26ahr 4164 39 the the DT cord-028721-x6f26ahr 4164 40 seventh seventh JJ cord-028721-x6f26ahr 4164 41 transmembrane transmembrane NN cord-028721-x6f26ahr 4164 42 domain domain NN cord-028721-x6f26ahr 4164 43 Biological biological JJ cord-028721-x6f26ahr 4164 44 effect effect NN cord-028721-x6f26ahr 4164 45 of of IN cord-028721-x6f26ahr 4164 46 a a DT cord-028721-x6f26ahr 4164 47 novel novel JJ cord-028721-x6f26ahr 4164 48 mutation mutation NN cord-028721-x6f26ahr 4164 49 in in IN cord-028721-x6f26ahr 4164 50 the the DT cord-028721-x6f26ahr 4164 51 third third JJ cord-028721-x6f26ahr 4164 52 leucine leucine NN cord-028721-x6f26ahr 4164 53 - - HYPH cord-028721-x6f26ahr 4164 54 rich rich JJ cord-028721-x6f26ahr 4164 55 repeat repeat NN cord-028721-x6f26ahr 4164 56 of of IN cord-028721-x6f26ahr 4164 57 human human JJ cord-028721-x6f26ahr 4164 58 luteinizing luteinize VBG cord-028721-x6f26ahr 4164 59 hormone hormone NN cord-028721-x6f26ahr 4164 60 References reference NNS cord-028721-x6f26ahr 4164 61 receptor receptor NN cord-028721-x6f26ahr 4164 62 Familial familial JJ cord-028721-x6f26ahr 4164 63 incomplete incomplete JJ cord-028721-x6f26ahr 4164 64 male male JJ cord-028721-x6f26ahr 4164 65 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4164 66 , , , cord-028721-x6f26ahr 4164 67 type type NN cord-028721-x6f26ahr 4164 68 I. i. NN cord-028721-x6f26ahr 4164 69 Evidence evidence NN cord-028721-x6f26ahr 4164 70 for for IN cord-028721-x6f26ahr 4164 71 androgen androgen NN cord-028721-x6f26ahr 4164 72 resistance resistance NN cord-028721-x6f26ahr 4164 73 and and CC cord-028721-x6f26ahr 4164 74 variable variable JJ cord-028721-x6f26ahr 4164 75 clinical clinical JJ cord-028721-x6f26ahr 4164 76 manifestations manifestation NNS cord-028721-x6f26ahr 4164 77 in in IN cord-028721-x6f26ahr 4164 78 a a DT cord-028721-x6f26ahr 4164 79 family family NN cord-028721-x6f26ahr 4164 80 with with IN cord-028721-x6f26ahr 4164 81 the the DT cord-028721-x6f26ahr 4164 82 Reifenstein Reifenstein NNP cord-028721-x6f26ahr 4164 83 syndrome syndrome NN cord-028721-x6f26ahr 4164 84 Quantitative quantitative JJ cord-028721-x6f26ahr 4164 85 receptor receptor NN cord-028721-x6f26ahr 4164 86 defects defect NNS cord-028721-x6f26ahr 4164 87 in in IN cord-028721-x6f26ahr 4164 88 families family NNS cord-028721-x6f26ahr 4164 89 with with IN cord-028721-x6f26ahr 4164 90 androgen androgen NN cord-028721-x6f26ahr 4164 91 resistance resistance NN cord-028721-x6f26ahr 4164 92 ; ; : cord-028721-x6f26ahr 4164 93 failure failure NN cord-028721-x6f26ahr 4164 94 of of IN cord-028721-x6f26ahr 4164 95 stabilization stabilization NN cord-028721-x6f26ahr 4164 96 of of IN cord-028721-x6f26ahr 4164 97 the the DT cord-028721-x6f26ahr 4164 98 fi fi NN cord-028721-x6f26ahr 4164 99 broblast broblast NN cord-028721-x6f26ahr 4164 100 cytosol cytosol NN cord-028721-x6f26ahr 4164 101 androgen androgen NN cord-028721-x6f26ahr 4164 102 receptor receptor NN cord-028721-x6f26ahr 4164 103 Leydig Leydig NNP cord-028721-x6f26ahr 4164 104 cell cell NN cord-028721-x6f26ahr 4164 105 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4164 106 determining determine VBG cord-028721-x6f26ahr 4164 107 familial familial JJ cord-028721-x6f26ahr 4164 108 hypergonadotropic hypergonadotropic NNP cord-028721-x6f26ahr 4164 109 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 4164 110 Male male JJ cord-028721-x6f26ahr 4164 111 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4164 112 resulting result VBG cord-028721-x6f26ahr 4164 113 from from IN cord-028721-x6f26ahr 4164 114 Leydig Leydig NNP cord-028721-x6f26ahr 4164 115 cell cell NN cord-028721-x6f26ahr 4164 116 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4165 1 The the DT cord-028721-x6f26ahr 4165 2 syndrome syndrome NN cord-028721-x6f26ahr 4165 3 of of IN cord-028721-x6f26ahr 4165 4 testicular testicular JJ cord-028721-x6f26ahr 4165 5 feminization feminization NN cord-028721-x6f26ahr 4165 6 in in IN cord-028721-x6f26ahr 4165 7 male male JJ cord-028721-x6f26ahr 4165 8 pseudohermaphrodites pseudohermaphrodite NNS cord-028721-x6f26ahr 4166 1 The the DT cord-028721-x6f26ahr 4166 2 molecular molecular JJ cord-028721-x6f26ahr 4166 3 bases basis NNS cord-028721-x6f26ahr 4166 4 of of IN cord-028721-x6f26ahr 4166 5 androgen androgen NN cord-028721-x6f26ahr 4166 6 insensitivity insensitivity NN cord-028721-x6f26ahr 4166 7 Molecular molecular JJ cord-028721-x6f26ahr 4166 8 basis basis NN cord-028721-x6f26ahr 4166 9 of of IN cord-028721-x6f26ahr 4166 10 androgen androgen NN cord-028721-x6f26ahr 4166 11 insensitivity insensitivity NN cord-028721-x6f26ahr 4167 1 The the DT cord-028721-x6f26ahr 4167 2 androgen androgen NN cord-028721-x6f26ahr 4167 3 insensitivity insensitivity NN cord-028721-x6f26ahr 4167 4 syndrome syndrome NN cord-028721-x6f26ahr 4167 5 ( ( -LRB- cord-028721-x6f26ahr 4167 6 testicular testicular JJ cord-028721-x6f26ahr 4167 7 feminization feminization NN cord-028721-x6f26ahr 4167 8 ) ) -RRB- cord-028721-x6f26ahr 4167 9 . . . cord-028721-x6f26ahr 4168 1 A a DT cord-028721-x6f26ahr 4168 2 clnicopathologic clnicopathologic JJ cord-028721-x6f26ahr 4168 3 study study NN cord-028721-x6f26ahr 4168 4 of of IN cord-028721-x6f26ahr 4168 5 43 43 CD cord-028721-x6f26ahr 4168 6 cases case NNS cord-028721-x6f26ahr 4168 7 A a DT cord-028721-x6f26ahr 4168 8 case case NN cord-028721-x6f26ahr 4168 9 of of IN cord-028721-x6f26ahr 4168 10 complete complete JJ cord-028721-x6f26ahr 4168 11 testicular testicular JJ cord-028721-x6f26ahr 4168 12 feminization feminization NN cord-028721-x6f26ahr 4168 13 and and CC cord-028721-x6f26ahr 4168 14 47 47 CD cord-028721-x6f26ahr 4168 15 XXY xxy NN cord-028721-x6f26ahr 4168 16 karyotype karyotype NN cord-028721-x6f26ahr 4168 17 Morphometry Morphometry NNP cord-028721-x6f26ahr 4168 18 and and CC cord-028721-x6f26ahr 4168 19 histology histology NN cord-028721-x6f26ahr 4168 20 of of IN cord-028721-x6f26ahr 4168 21 gonads gonad NNS cord-028721-x6f26ahr 4168 22 from from IN cord-028721-x6f26ahr 4168 23 twelve twelve CD cord-028721-x6f26ahr 4168 24 children child NNS cord-028721-x6f26ahr 4168 25 and and CC cord-028721-x6f26ahr 4168 26 adolescents adolescent NNS cord-028721-x6f26ahr 4168 27 with with IN cord-028721-x6f26ahr 4168 28 the the DT cord-028721-x6f26ahr 4168 29 androgen androgen NN cord-028721-x6f26ahr 4168 30 insensitivity insensitivity NN cord-028721-x6f26ahr 4168 31 ( ( -LRB- cord-028721-x6f26ahr 4168 32 testicular testicular JJ cord-028721-x6f26ahr 4168 33 feminization feminization NN cord-028721-x6f26ahr 4168 34 ) ) -RRB- cord-028721-x6f26ahr 4169 1 syndrome syndrome NN cord-028721-x6f26ahr 4169 2 Testicular Testicular NNP cord-028721-x6f26ahr 4169 3 carcinoma carcinoma NN cord-028721-x6f26ahr 4169 4 in in IN cord-028721-x6f26ahr 4169 5 situ situ NN cord-028721-x6f26ahr 4169 6 in in IN cord-028721-x6f26ahr 4169 7 children child NNS cord-028721-x6f26ahr 4169 8 with with IN cord-028721-x6f26ahr 4169 9 the the DT cord-028721-x6f26ahr 4169 10 androgen androgen NN cord-028721-x6f26ahr 4169 11 insensitivity insensitivity NN cord-028721-x6f26ahr 4169 12 ( ( -LRB- cord-028721-x6f26ahr 4169 13 testicular testicular JJ cord-028721-x6f26ahr 4169 14 feminization feminization NN cord-028721-x6f26ahr 4169 15 ) ) -RRB- cord-028721-x6f26ahr 4169 16 syndrome syndrome NN cord-028721-x6f26ahr 4169 17 Síndrome Síndrome NNP cord-028721-x6f26ahr 4169 18 de de IN cord-028721-x6f26ahr 4169 19 feminización feminización NN cord-028721-x6f26ahr 4169 20 testicular testicular NN cord-028721-x6f26ahr 4170 1 completa completa NNP cord-028721-x6f26ahr 4170 2 Inmunohistochemical Inmunohistochemical NNP cord-028721-x6f26ahr 4170 3 and and CC cord-028721-x6f26ahr 4170 4 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4170 5 study study NN cord-028721-x6f26ahr 4170 6 of of IN cord-028721-x6f26ahr 4170 7 Sertoli Sertoli NNP cord-028721-x6f26ahr 4170 8 cells cell NNS cord-028721-x6f26ahr 4170 9 in in IN cord-028721-x6f26ahr 4170 10 androgen androgen NN cord-028721-x6f26ahr 4170 11 insensitivity insensitivity NN cord-028721-x6f26ahr 4170 12 Androgen Androgen NNP cord-028721-x6f26ahr 4170 13 receptor receptor NN cord-028721-x6f26ahr 4170 14 gene gene NN cord-028721-x6f26ahr 4170 15 mutation mutation NN cord-028721-x6f26ahr 4170 16 associated associate VBN cord-028721-x6f26ahr 4170 17 with with IN cord-028721-x6f26ahr 4170 18 complete complete JJ cord-028721-x6f26ahr 4170 19 androgen androgen NN cord-028721-x6f26ahr 4170 20 insensitivity insensitivity NN cord-028721-x6f26ahr 4170 21 syndrome syndrome NN cord-028721-x6f26ahr 4170 22 and and CC cord-028721-x6f26ahr 4170 23 Sertoli sertoli JJ cord-028721-x6f26ahr 4170 24 cell cell NN cord-028721-x6f26ahr 4170 25 adenoma adenoma NN cord-028721-x6f26ahr 4170 26 Residual residual JJ cord-028721-x6f26ahr 4170 27 activity activity NN cord-028721-x6f26ahr 4170 28 of of IN cord-028721-x6f26ahr 4170 29 mutant mutant JJ cord-028721-x6f26ahr 4170 30 androgen androgen NN cord-028721-x6f26ahr 4170 31 receptors receptor NNS cord-028721-x6f26ahr 4170 32 explains explain VBZ cord-028721-x6f26ahr 4170 33 wolffi wolffi NNP cord-028721-x6f26ahr 4170 34 an an DT cord-028721-x6f26ahr 4170 35 duct duct NN cord-028721-x6f26ahr 4170 36 development development NN cord-028721-x6f26ahr 4170 37 in in IN cord-028721-x6f26ahr 4170 38 the the DT cord-028721-x6f26ahr 4170 39 complete complete JJ cord-028721-x6f26ahr 4170 40 androgen androgen NN cord-028721-x6f26ahr 4170 41 insensitivity insensitivity NN cord-028721-x6f26ahr 4170 42 syndrome syndrome NN cord-028721-x6f26ahr 4170 43 Bilateral bilateral JJ cord-028721-x6f26ahr 4170 44 testicular testicular JJ cord-028721-x6f26ahr 4170 45 tumors tumor NNS cord-028721-x6f26ahr 4170 46 in in IN cord-028721-x6f26ahr 4170 47 androgen androgen NN cord-028721-x6f26ahr 4170 48 insensitivity insensitivity NN cord-028721-x6f26ahr 4170 49 syndrome syndrome NN cord-028721-x6f26ahr 4170 50 Puberty Puberty NNP cord-028721-x6f26ahr 4170 51 in in IN cord-028721-x6f26ahr 4170 52 subjects subject NNS cord-028721-x6f26ahr 4170 53 with with IN cord-028721-x6f26ahr 4170 54 complete complete JJ cord-028721-x6f26ahr 4170 55 androgen androgen NN cord-028721-x6f26ahr 4170 56 insensitivity insensitivity NN cord-028721-x6f26ahr 4170 57 syndrome syndrome NN cord-028721-x6f26ahr 4170 58 Familial familial JJ cord-028721-x6f26ahr 4170 59 male male JJ cord-028721-x6f26ahr 4170 60 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4170 61 with with IN cord-028721-x6f26ahr 4170 62 labial labial JJ cord-028721-x6f26ahr 4170 63 testes testis NNS cord-028721-x6f26ahr 4170 64 and and CC cord-028721-x6f26ahr 4170 65 partial partial JJ cord-028721-x6f26ahr 4170 66 feminization feminization NN cord-028721-x6f26ahr 4170 67 : : : cord-028721-x6f26ahr 4170 68 endocrine endocrine JJ cord-028721-x6f26ahr 4170 69 studies study NNS cord-028721-x6f26ahr 4170 70 and and CC cord-028721-x6f26ahr 4170 71 genetic genetic JJ cord-028721-x6f26ahr 4170 72 aspects aspect NNS cord-028721-x6f26ahr 4171 1 Altered alter VBN cord-028721-x6f26ahr 4171 2 hypothalamic hypothalamic JJ cord-028721-x6f26ahr 4171 3 - - HYPH cord-028721-x6f26ahr 4171 4 pituitarytesticular pituitarytesticular JJ cord-028721-x6f26ahr 4171 5 function function NN cord-028721-x6f26ahr 4171 6 in in IN cord-028721-x6f26ahr 4171 7 incomplete incomplete JJ cord-028721-x6f26ahr 4171 8 testicular testicular JJ cord-028721-x6f26ahr 4171 9 feminization feminization NN cord-028721-x6f26ahr 4171 10 syndrome syndrome NN cord-028721-x6f26ahr 4171 11 Etude Etude NNP cord-028721-x6f26ahr 4171 12 d'un d'un FW cord-028721-x6f26ahr 4171 13 cas cas NNP cord-028721-x6f26ahr 4171 14 familial familial JJ cord-028721-x6f26ahr 4171 15 d'androgynoïdisme d'androgynoïdisme NNP cord-028721-x6f26ahr 4171 16 avec avec FW cord-028721-x6f26ahr 4171 17 hypospadias hypospadias NNP cord-028721-x6f26ahr 4171 18 grave grave JJ cord-028721-x6f26ahr 4171 19 , , , cord-028721-x6f26ahr 4171 20 gynécomastie gynécomastie NNP cord-028721-x6f26ahr 4171 21 et et NNP cord-028721-x6f26ahr 4171 22 hyperoestrogénie hyperoestrogénie NNP cord-028721-x6f26ahr 4171 23 Hereditary hereditary JJ cord-028721-x6f26ahr 4171 24 familial familial JJ cord-028721-x6f26ahr 4171 25 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4171 26 Familial familial JJ cord-028721-x6f26ahr 4171 27 gynecomastia gynecomastia NN cord-028721-x6f26ahr 4172 1 Androgens androgen NNS cord-028721-x6f26ahr 4172 2 and and CC cord-028721-x6f26ahr 4172 3 fertility fertility NN cord-028721-x6f26ahr 4172 4 Variable variable JJ cord-028721-x6f26ahr 4172 5 androgen androgen NN cord-028721-x6f26ahr 4172 6 receptor receptor NN cord-028721-x6f26ahr 4172 7 levels level NNS cord-028721-x6f26ahr 4172 8 in in IN cord-028721-x6f26ahr 4172 9 infertile infertile JJ cord-028721-x6f26ahr 4172 10 men man NNS cord-028721-x6f26ahr 4172 11 Frecuency Frecuency NNP cord-028721-x6f26ahr 4172 12 of of IN cord-028721-x6f26ahr 4172 13 androgen androgen NN cord-028721-x6f26ahr 4172 14 insensitivity insensitivity NN cord-028721-x6f26ahr 4172 15 in in IN cord-028721-x6f26ahr 4172 16 infertile infertile JJ cord-028721-x6f26ahr 4172 17 phenotypically phenotypically RB cord-028721-x6f26ahr 4172 18 normal normal JJ cord-028721-x6f26ahr 4172 19 men man NNS cord-028721-x6f26ahr 4172 20 Analysis Analysis NNP cord-028721-x6f26ahr 4172 21 of of IN cord-028721-x6f26ahr 4172 22 the the DT cord-028721-x6f26ahr 4172 23 transactivation transactivation NN cord-028721-x6f26ahr 4172 24 domain domain NN cord-028721-x6f26ahr 4172 25 of of IN cord-028721-x6f26ahr 4172 26 the the DT cord-028721-x6f26ahr 4172 27 androgen androgen NN cord-028721-x6f26ahr 4172 28 receptor receptor NN cord-028721-x6f26ahr 4172 29 in in IN cord-028721-x6f26ahr 4172 30 patients patient NNS cord-028721-x6f26ahr 4172 31 with with IN cord-028721-x6f26ahr 4172 32 male male JJ cord-028721-x6f26ahr 4172 33 infertility infertility NN cord-028721-x6f26ahr 4172 34 Evidence evidence NN cord-028721-x6f26ahr 4172 35 for for IN cord-028721-x6f26ahr 4172 36 partial partial JJ cord-028721-x6f26ahr 4172 37 deletion deletion NN cord-028721-x6f26ahr 4172 38 in in IN cord-028721-x6f26ahr 4172 39 the the DT cord-028721-x6f26ahr 4172 40 androgen androgen NN cord-028721-x6f26ahr 4172 41 receptor receptor NN cord-028721-x6f26ahr 4172 42 gene gene NN cord-028721-x6f26ahr 4172 43 in in IN cord-028721-x6f26ahr 4172 44 a a DT cord-028721-x6f26ahr 4172 45 phenotypic phenotypic JJ cord-028721-x6f26ahr 4172 46 male male NN cord-028721-x6f26ahr 4172 47 with with IN cord-028721-x6f26ahr 4172 48 azoospermia azoospermia NN cord-028721-x6f26ahr 4172 49 Preserved preserve VBN cord-028721-x6f26ahr 4172 50 male male JJ cord-028721-x6f26ahr 4172 51 fertility fertility NN cord-028721-x6f26ahr 4172 52 despite despite IN cord-028721-x6f26ahr 4172 53 decreased decrease VBD cord-028721-x6f26ahr 4172 54 androgen androgen NN cord-028721-x6f26ahr 4172 55 sensitivity sensitivity NN cord-028721-x6f26ahr 4172 56 caused cause VBN cord-028721-x6f26ahr 4172 57 by by IN cord-028721-x6f26ahr 4172 58 a a DT cord-028721-x6f26ahr 4172 59 mutation mutation NN cord-028721-x6f26ahr 4172 60 in in IN cord-028721-x6f26ahr 4172 61 the the DT cord-028721-x6f26ahr 4172 62 ligand ligand NN cord-028721-x6f26ahr 4172 63 - - HYPH cord-028721-x6f26ahr 4172 64 binding bind VBG cord-028721-x6f26ahr 4172 65 domain domain NN cord-028721-x6f26ahr 4172 66 of of IN cord-028721-x6f26ahr 4172 67 the the DT cord-028721-x6f26ahr 4172 68 androgen androgen NN cord-028721-x6f26ahr 4172 69 receptor receptor NN cord-028721-x6f26ahr 4172 70 gene gene NN cord-028721-x6f26ahr 4172 71 Progressive progressive JJ cord-028721-x6f26ahr 4172 72 proximal proximal JJ cord-028721-x6f26ahr 4172 73 spinal spinal JJ cord-028721-x6f26ahr 4172 74 and and CC cord-028721-x6f26ahr 4172 75 bulbar bulbar JJ cord-028721-x6f26ahr 4172 76 muscular muscular JJ cord-028721-x6f26ahr 4172 77 atrophy atrophy NN cord-028721-x6f26ahr 4172 78 of of IN cord-028721-x6f26ahr 4172 79 late late JJ cord-028721-x6f26ahr 4172 80 onset onset NN cord-028721-x6f26ahr 4172 81 . . . cord-028721-x6f26ahr 4173 1 A a DT cord-028721-x6f26ahr 4173 2 sex sex NN cord-028721-x6f26ahr 4173 3 - - HYPH cord-028721-x6f26ahr 4173 4 linked link VBN cord-028721-x6f26ahr 4173 5 recessive recessive JJ cord-028721-x6f26ahr 4173 6 trait trait NN cord-028721-x6f26ahr 4173 7 Founder founder NN cord-028721-x6f26ahr 4173 8 effect effect NN cord-028721-x6f26ahr 4173 9 in in IN cord-028721-x6f26ahr 4173 10 spinal spinal JJ cord-028721-x6f26ahr 4173 11 and and CC cord-028721-x6f26ahr 4173 12 bulbar bulbar JJ cord-028721-x6f26ahr 4173 13 muscular muscular JJ cord-028721-x6f26ahr 4173 14 atrophy atrophy NN cord-028721-x6f26ahr 4173 15 ( ( -LRB- cord-028721-x6f26ahr 4173 16 SBMA SBMA NNP cord-028721-x6f26ahr 4173 17 ) ) -RRB- cord-028721-x6f26ahr 4174 1 X X NNS cord-028721-x6f26ahr 4174 2 - - HYPH cord-028721-x6f26ahr 4174 3 linked link VBN cord-028721-x6f26ahr 4174 4 recessive recessive JJ cord-028721-x6f26ahr 4174 5 bulbospinal bulbospinal JJ cord-028721-x6f26ahr 4174 6 neuronopathy neuronopathy NNP cord-028721-x6f26ahr 4174 7 : : : cord-028721-x6f26ahr 4175 1 a a DT cord-028721-x6f26ahr 4175 2 clinicopathological clinicopathological JJ cord-028721-x6f26ahr 4175 3 study study NN cord-028721-x6f26ahr 4175 4 X X NNS cord-028721-x6f26ahr 4175 5 - - HYPH cord-028721-x6f26ahr 4175 6 linked link VBN cord-028721-x6f26ahr 4175 7 recessive recessive JJ cord-028721-x6f26ahr 4175 8 bulbospinal bulbospinal JJ cord-028721-x6f26ahr 4175 9 neuronopathy neuronopathy NNP cord-028721-x6f26ahr 4175 10 : : : cord-028721-x6f26ahr 4176 1 a a DT cord-028721-x6f26ahr 4176 2 report report NN cord-028721-x6f26ahr 4176 3 of of IN cord-028721-x6f26ahr 4176 4 ten ten CD cord-028721-x6f26ahr 4176 5 cases case NNS cord-028721-x6f26ahr 4176 6 X x NN cord-028721-x6f26ahr 4176 7 - - HYPH cord-028721-x6f26ahr 4176 8 Linked link VBN cord-028721-x6f26ahr 4176 9 spinal spinal JJ cord-028721-x6f26ahr 4176 10 and and CC cord-028721-x6f26ahr 4176 11 bulbar bulbar JJ cord-028721-x6f26ahr 4176 12 muscular muscular JJ cord-028721-x6f26ahr 4176 13 atrophy atrophy NN cord-028721-x6f26ahr 4176 14 of of IN cord-028721-x6f26ahr 4176 15 late late JJ cord-028721-x6f26ahr 4176 16 onset onset NN cord-028721-x6f26ahr 4176 17 . . . cord-028721-x6f26ahr 4177 1 A a DT cord-028721-x6f26ahr 4177 2 separate separate JJ cord-028721-x6f26ahr 4177 3 type type NN cord-028721-x6f26ahr 4177 4 of of IN cord-028721-x6f26ahr 4177 5 motor motor NN cord-028721-x6f26ahr 4177 6 neuron neuron NN cord-028721-x6f26ahr 4177 7 disease disease NN cord-028721-x6f26ahr 4177 8 ? ? . cord-028721-x6f26ahr 4178 1 A a DT cord-028721-x6f26ahr 4178 2 family family NN cord-028721-x6f26ahr 4178 3 with with IN cord-028721-x6f26ahr 4178 4 adult adult NN cord-028721-x6f26ahr 4178 5 spinal spinal JJ cord-028721-x6f26ahr 4178 6 and and CC cord-028721-x6f26ahr 4178 7 bulbar bulbar JJ cord-028721-x6f26ahr 4178 8 muscular muscular JJ cord-028721-x6f26ahr 4178 9 atrophy atrophy NN cord-028721-x6f26ahr 4178 10 , , , cord-028721-x6f26ahr 4178 11 X x NN cord-028721-x6f26ahr 4178 12 - - HYPH cord-028721-x6f26ahr 4178 13 linked link VBN cord-028721-x6f26ahr 4178 14 inheritance inheritance NN cord-028721-x6f26ahr 4178 15 and and CC cord-028721-x6f26ahr 4178 16 associated associate VBN cord-028721-x6f26ahr 4178 17 testicular testicular JJ cord-028721-x6f26ahr 4178 18 failure failure NN cord-028721-x6f26ahr 4179 1 Androgen androgen NN cord-028721-x6f26ahr 4179 2 receptor receptor NN cord-028721-x6f26ahr 4179 3 gene gene NN cord-028721-x6f26ahr 4179 4 mutations mutation NNS cord-028721-x6f26ahr 4179 5 in in IN cord-028721-x6f26ahr 4179 6 X x NN cord-028721-x6f26ahr 4179 7 - - HYPH cord-028721-x6f26ahr 4179 8 linked link VBN cord-028721-x6f26ahr 4179 9 spinal spinal JJ cord-028721-x6f26ahr 4179 10 and and CC cord-028721-x6f26ahr 4179 11 bulbar bulbar JJ cord-028721-x6f26ahr 4179 12 muscular muscular JJ cord-028721-x6f26ahr 4179 13 atrophy atrophy NN cord-028721-x6f26ahr 4179 14 Meiotic meiotic JJ cord-028721-x6f26ahr 4179 15 stability stability NN cord-028721-x6f26ahr 4179 16 and and CC cord-028721-x6f26ahr 4179 17 genotypephenotype genotypephenotype JJ cord-028721-x6f26ahr 4179 18 correlation correlation NN cord-028721-x6f26ahr 4179 19 of of IN cord-028721-x6f26ahr 4179 20 the the DT cord-028721-x6f26ahr 4179 21 tricucleotide tricucleotide NNP cord-028721-x6f26ahr 4179 22 repeat repeat VBP cord-028721-x6f26ahr 4179 23 in in IN cord-028721-x6f26ahr 4179 24 X x NN cord-028721-x6f26ahr 4179 25 - - HYPH cord-028721-x6f26ahr 4179 26 linked link VBN cord-028721-x6f26ahr 4179 27 spinal spinal JJ cord-028721-x6f26ahr 4179 28 and and CC cord-028721-x6f26ahr 4179 29 bulbar bulbar JJ cord-028721-x6f26ahr 4179 30 muscular muscular JJ cord-028721-x6f26ahr 4179 31 atrophy atrophy NN cord-028721-x6f26ahr 4179 32 The the DT cord-028721-x6f26ahr 4179 33 length length NN cord-028721-x6f26ahr 4179 34 and and CC cord-028721-x6f26ahr 4179 35 location location NN cord-028721-x6f26ahr 4179 36 of of IN cord-028721-x6f26ahr 4179 37 CAG CAG NNP cord-028721-x6f26ahr 4179 38 trinucleotide trinucleotide NNP cord-028721-x6f26ahr 4179 39 repeats repeat VBZ cord-028721-x6f26ahr 4179 40 in in IN cord-028721-x6f26ahr 4179 41 the the DT cord-028721-x6f26ahr 4179 42 androgen androgen NN cord-028721-x6f26ahr 4179 43 receptor receptor NN cord-028721-x6f26ahr 4179 44 N n CD cord-028721-x6f26ahr 4179 45 - - HYPH cord-028721-x6f26ahr 4179 46 terminal terminal NN cord-028721-x6f26ahr 4179 47 domain domain NN cord-028721-x6f26ahr 4179 48 affect affect VBP cord-028721-x6f26ahr 4179 49 transactivation transactivation NN cord-028721-x6f26ahr 4179 50 function function VBP cord-028721-x6f26ahr 4179 51 Abnormal abnormal JJ cord-028721-x6f26ahr 4179 52 androgen androgen NN cord-028721-x6f26ahr 4179 53 receptor receptor NN cord-028721-x6f26ahr 4179 54 binding bind VBG cord-028721-x6f26ahr 4179 55 affi affi FW cord-028721-x6f26ahr 4179 56 nity nity NN cord-028721-x6f26ahr 4179 57 in in IN cord-028721-x6f26ahr 4179 58 subjects subject NNS cord-028721-x6f26ahr 4179 59 with with IN cord-028721-x6f26ahr 4179 60 Kennedy Kennedy NNP cord-028721-x6f26ahr 4179 61 's 's POS cord-028721-x6f26ahr 4179 62 disease disease NN cord-028721-x6f26ahr 4179 63 ( ( -LRB- cord-028721-x6f26ahr 4179 64 spinal spinal JJ cord-028721-x6f26ahr 4179 65 and and CC cord-028721-x6f26ahr 4179 66 bulbar bulbar JJ cord-028721-x6f26ahr 4179 67 muscular muscular JJ cord-028721-x6f26ahr 4179 68 atrophy atrophy NN cord-028721-x6f26ahr 4179 69 ) ) -RRB- cord-028721-x6f26ahr 4180 1 Molecular molecular JJ cord-028721-x6f26ahr 4180 2 pathology pathology NN cord-028721-x6f26ahr 4180 3 of of IN cord-028721-x6f26ahr 4180 4 the the DT cord-028721-x6f26ahr 4180 5 androgen androgen NN cord-028721-x6f26ahr 4180 6 receptor receptor NN cord-028721-x6f26ahr 4180 7 in in IN cord-028721-x6f26ahr 4180 8 male male NN cord-028721-x6f26ahr 4180 9 ( ( -LRB- cord-028721-x6f26ahr 4180 10 in)fertility in)fertility NNP cord-028721-x6f26ahr 4180 11 Steroid Steroid NNP cord-028721-x6f26ahr 4180 12 5 5 CD cord-028721-x6f26ahr 4180 13 alpha alpha NN cord-028721-x6f26ahr 4180 14 - - HYPH cord-028721-x6f26ahr 4180 15 reductase reductase NN cord-028721-x6f26ahr 4180 16 defi defi NNP cord-028721-x6f26ahr 4180 17 ciency ciency NN cord-028721-x6f26ahr 4180 18 in in IN cord-028721-x6f26ahr 4180 19 man man NN cord-028721-x6f26ahr 4180 20 . . . cord-028721-x6f26ahr 4181 1 An an DT cord-028721-x6f26ahr 4181 2 inherited inherit VBN cord-028721-x6f26ahr 4181 3 form form NN cord-028721-x6f26ahr 4181 4 of of IN cord-028721-x6f26ahr 4181 5 male male JJ cord-028721-x6f26ahr 4181 6 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4181 7 Identifi Identifi NNP cord-028721-x6f26ahr 4181 8 cation cation NN cord-028721-x6f26ahr 4181 9 of of IN cord-028721-x6f26ahr 4181 10 missense missense NNP cord-028721-x6f26ahr 4181 11 mutations mutation NNS cord-028721-x6f26ahr 4181 12 in in IN cord-028721-x6f26ahr 4181 13 the the DT cord-028721-x6f26ahr 4181 14 SRD5A2 srd5a2 CD cord-028721-x6f26ahr 4181 15 gene gene NN cord-028721-x6f26ahr 4181 16 from from IN cord-028721-x6f26ahr 4181 17 patients patient NNS cord-028721-x6f26ahr 4181 18 with with IN cord-028721-x6f26ahr 4181 19 steroid steroid JJ cord-028721-x6f26ahr 4181 20 5alpha 5alpha CD cord-028721-x6f26ahr 4181 21 - - HYPH cord-028721-x6f26ahr 4181 22 reductase reductase NN cord-028721-x6f26ahr 4181 23 2 2 CD cord-028721-x6f26ahr 4181 24 defi defi NN cord-028721-x6f26ahr 4181 25 ciency ciency NNP cord-028721-x6f26ahr 4181 26 Deletion deletion NN cord-028721-x6f26ahr 4181 27 of of IN cord-028721-x6f26ahr 4181 28 steroid steroid NN cord-028721-x6f26ahr 4181 29 5 5 CD cord-028721-x6f26ahr 4181 30 alpha alpha NN cord-028721-x6f26ahr 4181 31 reductase reductase NN cord-028721-x6f26ahr 4181 32 2 2 CD cord-028721-x6f26ahr 4181 33 gene gene NN cord-028721-x6f26ahr 4181 34 in in IN cord-028721-x6f26ahr 4181 35 male male JJ cord-028721-x6f26ahr 4181 36 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4181 37 Steroid Steroid NNP cord-028721-x6f26ahr 4181 38 5 5 CD cord-028721-x6f26ahr 4181 39 alpha alpha NN cord-028721-x6f26ahr 4181 40 - - HYPH cord-028721-x6f26ahr 4181 41 reductase reductase NN cord-028721-x6f26ahr 4181 42 2 2 CD cord-028721-x6f26ahr 4181 43 defi defi NN cord-028721-x6f26ahr 4181 44 ciency ciency NNP cord-028721-x6f26ahr 4182 1 Molecular molecular JJ cord-028721-x6f26ahr 4182 2 study study NN cord-028721-x6f26ahr 4182 3 of of IN cord-028721-x6f26ahr 4182 4 the the DT cord-028721-x6f26ahr 4182 5 5 5 CD cord-028721-x6f26ahr 4182 6 alpha alpha NN cord-028721-x6f26ahr 4182 7 - - HYPH cord-028721-x6f26ahr 4182 8 reductase reductase NN cord-028721-x6f26ahr 4182 9 type type NN cord-028721-x6f26ahr 4182 10 2 2 CD cord-028721-x6f26ahr 4182 11 gene gene NN cord-028721-x6f26ahr 4182 12 in in IN cord-028721-x6f26ahr 4182 13 three three CD cord-028721-x6f26ahr 4182 14 european european JJ cord-028721-x6f26ahr 4182 15 families family NNS cord-028721-x6f26ahr 4182 16 with with IN cord-028721-x6f26ahr 4182 17 5 5 CD cord-028721-x6f26ahr 4182 18 alphareductase alphareductase NNP cord-028721-x6f26ahr 4182 19 defi defi NNP cord-028721-x6f26ahr 4182 20 ciency ciency NNP cord-028721-x6f26ahr 4182 21 5alpha 5alpha CD cord-028721-x6f26ahr 4182 22 - - HYPH cord-028721-x6f26ahr 4182 23 reductase reductase NN cord-028721-x6f26ahr 4182 24 2 2 CD cord-028721-x6f26ahr 4182 25 gene gene NN cord-028721-x6f26ahr 4182 26 mutations mutation NNS cord-028721-x6f26ahr 4182 27 in in IN cord-028721-x6f26ahr 4182 28 three three CD cord-028721-x6f26ahr 4182 29 unrelated unrelated JJ cord-028721-x6f26ahr 4182 30 patients patient NNS cord-028721-x6f26ahr 4182 31 of of IN cord-028721-x6f26ahr 4182 32 Greek greek JJ cord-028721-x6f26ahr 4182 33 Cypriot cypriot JJ cord-028721-x6f26ahr 4182 34 origin origin NN cord-028721-x6f26ahr 4182 35 : : : cord-028721-x6f26ahr 4182 36 identifi identifi NNP cord-028721-x6f26ahr 4182 37 cation cation NNP cord-028721-x6f26ahr 4182 38 of of IN cord-028721-x6f26ahr 4182 39 an an DT cord-028721-x6f26ahr 4182 40 ancestral ancestral JJ cord-028721-x6f26ahr 4182 41 founder founder NN cord-028721-x6f26ahr 4182 42 effect effect NN cord-028721-x6f26ahr 4182 43 A a DT cord-028721-x6f26ahr 4182 44 novel novel JJ cord-028721-x6f26ahr 4182 45 frameshift frameshift NN cord-028721-x6f26ahr 4182 46 mutation mutation NN cord-028721-x6f26ahr 4182 47 in in IN cord-028721-x6f26ahr 4182 48 the the DT cord-028721-x6f26ahr 4182 49 5alpha 5alpha CD cord-028721-x6f26ahr 4182 50 - - HYPH cord-028721-x6f26ahr 4182 51 reductase reductase NN cord-028721-x6f26ahr 4182 52 type type NN cord-028721-x6f26ahr 4182 53 2 2 CD cord-028721-x6f26ahr 4182 54 gene gene NN cord-028721-x6f26ahr 4182 55 in in IN cord-028721-x6f26ahr 4182 56 Korean korean JJ cord-028721-x6f26ahr 4182 57 sisters sister NNS cord-028721-x6f26ahr 4182 58 with with IN cord-028721-x6f26ahr 4182 59 male male JJ cord-028721-x6f26ahr 4182 60 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4182 61 Testosterone testosterone NN cord-028721-x6f26ahr 4182 62 and and CC cord-028721-x6f26ahr 4182 63 epitestosterone epitestosterone NN cord-028721-x6f26ahr 4182 64 metabolism metabolism NN cord-028721-x6f26ahr 4182 65 of of IN cord-028721-x6f26ahr 4182 66 single single JJ cord-028721-x6f26ahr 4182 67 hairs hair NNS cord-028721-x6f26ahr 4182 68 in in IN cord-028721-x6f26ahr 4182 69 5 5 CD cord-028721-x6f26ahr 4182 70 patients patient NNS cord-028721-x6f26ahr 4182 71 with with IN cord-028721-x6f26ahr 4182 72 5 5 CD cord-028721-x6f26ahr 4182 73 alpha alpha NN cord-028721-x6f26ahr 4182 74 - - HYPH cord-028721-x6f26ahr 4182 75 reductasedefi reductasedefi NNP cord-028721-x6f26ahr 4182 76 ciency ciency NNP cord-028721-x6f26ahr 4182 77 Male Male NNP cord-028721-x6f26ahr 4182 78 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4182 79 due due JJ cord-028721-x6f26ahr 4182 80 to to IN cord-028721-x6f26ahr 4182 81 5 5 CD cord-028721-x6f26ahr 4182 82 alpha alpha NN cord-028721-x6f26ahr 4182 83 - - HYPH cord-028721-x6f26ahr 4182 84 reductase reductase NN cord-028721-x6f26ahr 4182 85 defi defi NNP cord-028721-x6f26ahr 4182 86 ciency ciency NNP cord-028721-x6f26ahr 4182 87 Male Male NNP cord-028721-x6f26ahr 4182 88 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4182 89 due due JJ cord-028721-x6f26ahr 4182 90 to to IN cord-028721-x6f26ahr 4182 91 steroid steroid NN cord-028721-x6f26ahr 4182 92 5 5 CD cord-028721-x6f26ahr 4182 93 alpha alpha NN cord-028721-x6f26ahr 4182 94 - - HYPH cord-028721-x6f26ahr 4182 95 reductase reductase NN cord-028721-x6f26ahr 4182 96 defi defi NN cord-028721-x6f26ahr 4182 97 ciency ciency NNP cord-028721-x6f26ahr 4182 98 Persistence Persistence NNP cord-028721-x6f26ahr 4182 99 of of IN cord-028721-x6f26ahr 4182 100 müllerian müllerian JJ cord-028721-x6f26ahr 4182 101 ducts duct NNS cord-028721-x6f26ahr 4182 102 in in IN cord-028721-x6f26ahr 4182 103 male male JJ cord-028721-x6f26ahr 4182 104 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4182 105 , , , cord-028721-x6f26ahr 4182 106 and and CC cord-028721-x6f26ahr 4182 107 its -PRON- PRP$ cord-028721-x6f26ahr 4182 108 relationship relationship NN cord-028721-x6f26ahr 4182 109 to to IN cord-028721-x6f26ahr 4182 110 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4182 111 Anti anti JJ cord-028721-x6f26ahr 4182 112 - - JJ cord-028721-x6f26ahr 4182 113 Müllerian müllerian JJ cord-028721-x6f26ahr 4182 114 hormone hormone NN cord-028721-x6f26ahr 4182 115 and and CC cord-028721-x6f26ahr 4182 116 intersex intersex NN cord-028721-x6f26ahr 4182 117 states state NNS cord-028721-x6f26ahr 4182 118 Anti anti JJ cord-028721-x6f26ahr 4182 119 - - JJ cord-028721-x6f26ahr 4182 120 Müllerian müllerian JJ cord-028721-x6f26ahr 4182 121 hormone hormone NN cord-028721-x6f26ahr 4182 122 , , , cord-028721-x6f26ahr 4182 123 the the DT cord-028721-x6f26ahr 4182 124 Jost Jost NNP cord-028721-x6f26ahr 4182 125 factor factor NN cord-028721-x6f26ahr 4183 1 The the DT cord-028721-x6f26ahr 4183 2 persistent persistent JJ cord-028721-x6f26ahr 4183 3 müllerian müllerian JJ cord-028721-x6f26ahr 4183 4 duct duct NN cord-028721-x6f26ahr 4183 5 syndrome syndrome NN cord-028721-x6f26ahr 4183 6 : : : cord-028721-x6f26ahr 4183 7 a a DT cord-028721-x6f26ahr 4183 8 rare rare JJ cord-028721-x6f26ahr 4183 9 cause cause NN cord-028721-x6f26ahr 4183 10 of of IN cord-028721-x6f26ahr 4183 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4183 12 Hermaphroditism Hermaphroditism NNP cord-028721-x6f26ahr 4183 13 with with IN cord-028721-x6f26ahr 4183 14 atypical atypical JJ cord-028721-x6f26ahr 4183 15 or or CC cord-028721-x6f26ahr 4183 16 ' ' `` cord-028721-x6f26ahr 4183 17 mixed mixed JJ cord-028721-x6f26ahr 4183 18 ' ' '' cord-028721-x6f26ahr 4183 19 gonadal gonadal JJ cord-028721-x6f26ahr 4183 20 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4183 21 . . . cord-028721-x6f26ahr 4184 1 Relationship relationship NN cord-028721-x6f26ahr 4184 2 to to IN cord-028721-x6f26ahr 4184 3 gonadal gonadal JJ cord-028721-x6f26ahr 4184 4 neoplasm neoplasm NN cord-028721-x6f26ahr 4184 5 Mixed mixed JJ cord-028721-x6f26ahr 4184 6 gonadal gonadal NN cord-028721-x6f26ahr 4184 7 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4184 8 Penoscrotal penoscrotal JJ cord-028721-x6f26ahr 4184 9 hypospadias hypospadia NNS cord-028721-x6f26ahr 4184 10 and and CC cord-028721-x6f26ahr 4184 11 coarctation coarctation NN cord-028721-x6f26ahr 4184 12 of of IN cord-028721-x6f26ahr 4184 13 the the DT cord-028721-x6f26ahr 4184 14 aorta aorta NN cord-028721-x6f26ahr 4184 15 with with IN cord-028721-x6f26ahr 4184 16 mixed mixed JJ cord-028721-x6f26ahr 4184 17 gonadal gonadal NN cord-028721-x6f26ahr 4184 18 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 4184 19 Molecular molecular JJ cord-028721-x6f26ahr 4184 20 analysis analysis NN cord-028721-x6f26ahr 4184 21 of of IN cord-028721-x6f26ahr 4184 22 SRY SRY NNP cord-028721-x6f26ahr 4184 23 gene gene NN cord-028721-x6f26ahr 4184 24 in in IN cord-028721-x6f26ahr 4184 25 patients patient NNS cord-028721-x6f26ahr 4184 26 with with IN cord-028721-x6f26ahr 4184 27 mixed mixed JJ cord-028721-x6f26ahr 4184 28 gonadal gonadal NN cord-028721-x6f26ahr 4184 29 dysgenesis dysgenesis NNP cord-028721-x6f26ahr 4184 30 Dysgenesis Dysgenesis NNP cord-028721-x6f26ahr 4184 31 of of IN cord-028721-x6f26ahr 4184 32 testicular testicular NNP cord-028721-x6f26ahr 4184 33 and and CC cord-028721-x6f26ahr 4184 34 streak streak NN cord-028721-x6f26ahr 4184 35 gonads gonad NNS cord-028721-x6f26ahr 4184 36 in in IN cord-028721-x6f26ahr 4184 37 the the DT cord-028721-x6f26ahr 4184 38 syndrome syndrome NN cord-028721-x6f26ahr 4184 39 of of IN cord-028721-x6f26ahr 4184 40 mixed mixed JJ cord-028721-x6f26ahr 4184 41 gonadal gonadal JJ cord-028721-x6f26ahr 4184 42 dysgenesis dysgenesi NNS cord-028721-x6f26ahr 4184 43 . . . cord-028721-x6f26ahr 4185 1 Perspective perspective NN cord-028721-x6f26ahr 4185 2 derived derive VBN cord-028721-x6f26ahr 4185 3 from from IN cord-028721-x6f26ahr 4185 4 a a DT cord-028721-x6f26ahr 4185 5 clinicopathologic clinicopathologic JJ cord-028721-x6f26ahr 4185 6 analysis analysis NN cord-028721-x6f26ahr 4185 7 of of IN cord-028721-x6f26ahr 4185 8 twentyone twentyone NN cord-028721-x6f26ahr 4185 9 cases case NNS cord-028721-x6f26ahr 4185 10 Clinical clinical JJ cord-028721-x6f26ahr 4185 11 and and CC cord-028721-x6f26ahr 4185 12 pathologic pathologic JJ cord-028721-x6f26ahr 4185 13 spectrum spectrum NN cord-028721-x6f26ahr 4185 14 of of IN cord-028721-x6f26ahr 4185 15 46,XY 46,xy CD cord-028721-x6f26ahr 4185 16 gonadal gonadal JJ cord-028721-x6f26ahr 4185 17 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4185 18 : : : cord-028721-x6f26ahr 4185 19 its -PRON- PRP$ cord-028721-x6f26ahr 4185 20 relevance relevance NN cord-028721-x6f26ahr 4185 21 to to IN cord-028721-x6f26ahr 4185 22 the the DT cord-028721-x6f26ahr 4185 23 understanding understanding NN cord-028721-x6f26ahr 4185 24 of of IN cord-028721-x6f26ahr 4185 25 sex sex NN cord-028721-x6f26ahr 4185 26 differentiation differentiation NN cord-028721-x6f26ahr 4186 1 Dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4186 2 male male JJ cord-028721-x6f26ahr 4186 3 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4186 4 Morphometry Morphometry NNP cord-028721-x6f26ahr 4186 5 and and CC cord-028721-x6f26ahr 4186 6 histology histology NN cord-028721-x6f26ahr 4186 7 of of IN cord-028721-x6f26ahr 4186 8 gonads gonad NNS cord-028721-x6f26ahr 4186 9 from from IN cord-028721-x6f26ahr 4186 10 13 13 CD cord-028721-x6f26ahr 4186 11 children child NNS cord-028721-x6f26ahr 4186 12 with with IN cord-028721-x6f26ahr 4186 13 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4186 14 male male JJ cord-028721-x6f26ahr 4186 15 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4186 16 Testicular Testicular NNP cord-028721-x6f26ahr 4186 17 pathology pathology NN cord-028721-x6f26ahr 4186 18 in in IN cord-028721-x6f26ahr 4186 19 46,XY 46,xy CD cord-028721-x6f26ahr 4187 1 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4187 2 male male JJ cord-028721-x6f26ahr 4187 3 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4187 4 : : : cord-028721-x6f26ahr 4187 5 an an DT cord-028721-x6f26ahr 4187 6 approach approach NN cord-028721-x6f26ahr 4187 7 to to IN cord-028721-x6f26ahr 4187 8 pathogenesis pathogenesis NN cord-028721-x6f26ahr 4187 9 of of IN cord-028721-x6f26ahr 4187 10 testis testis NN cord-028721-x6f26ahr 4187 11 cancer cancer NN cord-028721-x6f26ahr 4187 12 Hernia Hernia NNP cord-028721-x6f26ahr 4187 13 uteri uterus NNS cord-028721-x6f26ahr 4187 14 inguinalis inguinalis NNP cord-028721-x6f26ahr 4187 15 beim beim NNP cord-028721-x6f26ahr 4187 16 Manne Manne NNP cord-028721-x6f26ahr 4187 17 Persistence Persistence NNP cord-028721-x6f26ahr 4187 18 of of IN cord-028721-x6f26ahr 4187 19 müllerian müllerian JJ cord-028721-x6f26ahr 4187 20 derivatives derivative NNS cord-028721-x6f26ahr 4187 21 in in IN cord-028721-x6f26ahr 4187 22 males male NNS cord-028721-x6f26ahr 4187 23 Persistent persistent JJ cord-028721-x6f26ahr 4187 24 müllerian müllerian JJ cord-028721-x6f26ahr 4187 25 duct duct NN cord-028721-x6f26ahr 4187 26 syndrome syndrome NN cord-028721-x6f26ahr 4187 27 . . . cord-028721-x6f26ahr 4188 1 Review review VB cord-028721-x6f26ahr 4188 2 and and CC cord-028721-x6f26ahr 4188 3 report report VB cord-028721-x6f26ahr 4188 4 of of IN cord-028721-x6f26ahr 4188 5 3 3 CD cord-028721-x6f26ahr 4188 6 cases case NNS cord-028721-x6f26ahr 4189 1 Familial familial JJ cord-028721-x6f26ahr 4189 2 persistent persistent JJ cord-028721-x6f26ahr 4189 3 müllerian müllerian JJ cord-028721-x6f26ahr 4189 4 duct duct NN cord-028721-x6f26ahr 4189 5 syndrome syndrome NN cord-028721-x6f26ahr 4189 6 Persistent persistent JJ cord-028721-x6f26ahr 4189 7 müllerian müllerian JJ cord-028721-x6f26ahr 4189 8 duct duct NN cord-028721-x6f26ahr 4189 9 syndrome syndrome NN cord-028721-x6f26ahr 4189 10 in in IN cord-028721-x6f26ahr 4189 11 a a DT cord-028721-x6f26ahr 4189 12 man man NN cord-028721-x6f26ahr 4189 13 with with IN cord-028721-x6f26ahr 4189 14 transverse transverse JJ cord-028721-x6f26ahr 4189 15 testicular testicular JJ cord-028721-x6f26ahr 4189 16 ectopia ectopia NN cord-028721-x6f26ahr 4189 17 Persistent persistent JJ cord-028721-x6f26ahr 4189 18 müllerian müllerian JJ cord-028721-x6f26ahr 4189 19 structures structure NNS cord-028721-x6f26ahr 4189 20 in in IN cord-028721-x6f26ahr 4189 21 infertile infertile JJ cord-028721-x6f26ahr 4189 22 male male JJ cord-028721-x6f26ahr 4189 23 Male male JJ cord-028721-x6f26ahr 4189 24 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4189 25 with with IN cord-028721-x6f26ahr 4189 26 persistent persistent JJ cord-028721-x6f26ahr 4189 27 müllerian müllerian NN cord-028721-x6f26ahr 4189 28 and and CC cord-028721-x6f26ahr 4189 29 wolffi wolffi NNP cord-028721-x6f26ahr 4189 30 an an DT cord-028721-x6f26ahr 4189 31 structures structure NNS cord-028721-x6f26ahr 4189 32 complicated complicate VBN cord-028721-x6f26ahr 4189 33 by by IN cord-028721-x6f26ahr 4189 34 intraabdominal intraabdominal JJ cord-028721-x6f26ahr 4189 35 seminoma seminoma NN cord-028721-x6f26ahr 4189 36 Persistence persistence NN cord-028721-x6f26ahr 4189 37 of of IN cord-028721-x6f26ahr 4189 38 müllerian müllerian JJ cord-028721-x6f26ahr 4189 39 derivatives derivative NNS cord-028721-x6f26ahr 4189 40 in in IN cord-028721-x6f26ahr 4189 41 males male NNS cord-028721-x6f26ahr 4189 42 Familial familial JJ cord-028721-x6f26ahr 4189 43 persistent persistent JJ cord-028721-x6f26ahr 4189 44 müllerian müllerian JJ cord-028721-x6f26ahr 4189 45 duct duct NN cord-028721-x6f26ahr 4189 46 syndrome syndrome NN cord-028721-x6f26ahr 4189 47 Variants Variants NNPS cord-028721-x6f26ahr 4189 48 of of IN cord-028721-x6f26ahr 4189 49 the the DT cord-028721-x6f26ahr 4189 50 anti anti JJ cord-028721-x6f26ahr 4189 51 - - JJ cord-028721-x6f26ahr 4189 52 müllerian müllerian JJ cord-028721-x6f26ahr 4189 53 hormone hormone NN cord-028721-x6f26ahr 4189 54 gene gene NN cord-028721-x6f26ahr 4189 55 in in IN cord-028721-x6f26ahr 4189 56 a a DT cord-028721-x6f26ahr 4189 57 compound compound NN cord-028721-x6f26ahr 4189 58 heterozygote heterozygote NN cord-028721-x6f26ahr 4189 59 with with IN cord-028721-x6f26ahr 4189 60 the the DT cord-028721-x6f26ahr 4189 61 persistent persistent JJ cord-028721-x6f26ahr 4189 62 müllerian müllerian JJ cord-028721-x6f26ahr 4189 63 duct duct NN cord-028721-x6f26ahr 4189 64 syndrome syndrome NN cord-028721-x6f26ahr 4189 65 and and CC cord-028721-x6f26ahr 4189 66 his -PRON- PRP$ cord-028721-x6f26ahr 4189 67 family family NN cord-028721-x6f26ahr 4189 68 Diffuse diffuse VBP cord-028721-x6f26ahr 4189 69 intratubular intratubular JJ cord-028721-x6f26ahr 4189 70 undifferentiated undifferentiated JJ cord-028721-x6f26ahr 4189 71 germ germ NN cord-028721-x6f26ahr 4189 72 cell cell NN cord-028721-x6f26ahr 4189 73 tumor tumor NN cord-028721-x6f26ahr 4189 74 in in IN cord-028721-x6f26ahr 4189 75 both both DT cord-028721-x6f26ahr 4189 76 testes testis NNS cord-028721-x6f26ahr 4189 77 of of IN cord-028721-x6f26ahr 4189 78 a a DT cord-028721-x6f26ahr 4189 79 male male JJ cord-028721-x6f26ahr 4189 80 subject subject NN cord-028721-x6f26ahr 4189 81 with with IN cord-028721-x6f26ahr 4189 82 a a DT cord-028721-x6f26ahr 4189 83 uterus uterus NN cord-028721-x6f26ahr 4189 84 and and CC cord-028721-x6f26ahr 4189 85 ipsilateral ipsilateral JJ cord-028721-x6f26ahr 4189 86 testicular testicular NNP cord-028721-x6f26ahr 4189 87 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4189 88 Testicular Testicular NNP cord-028721-x6f26ahr 4189 89 tumor tumor NN cord-028721-x6f26ahr 4189 90 in in IN cord-028721-x6f26ahr 4189 91 patient patient NN cord-028721-x6f26ahr 4189 92 with with IN cord-028721-x6f26ahr 4189 93 persistent persistent JJ cord-028721-x6f26ahr 4189 94 müllerian müllerian JJ cord-028721-x6f26ahr 4189 95 duct duct NN cord-028721-x6f26ahr 4189 96 syndrome syndrome NN cord-028721-x6f26ahr 4190 1 A a DT cord-028721-x6f26ahr 4190 2 case case NN cord-028721-x6f26ahr 4190 3 of of IN cord-028721-x6f26ahr 4190 4 bilateral bilateral JJ cord-028721-x6f26ahr 4190 5 seminoma seminoma NN cord-028721-x6f26ahr 4190 6 in in IN cord-028721-x6f26ahr 4190 7 the the DT cord-028721-x6f26ahr 4190 8 setting setting NN cord-028721-x6f26ahr 4190 9 of of IN cord-028721-x6f26ahr 4190 10 persistent persistent JJ cord-028721-x6f26ahr 4190 11 müllerian müllerian JJ cord-028721-x6f26ahr 4190 12 duct duct NN cord-028721-x6f26ahr 4190 13 syndrome syndrome NN cord-028721-x6f26ahr 4190 14 RSH RSH NNP cord-028721-x6f26ahr 4190 15 / / SYM cord-028721-x6f26ahr 4190 16 Smith Smith NNP cord-028721-x6f26ahr 4190 17 - - HYPH cord-028721-x6f26ahr 4190 18 Lemli Lemli NNP cord-028721-x6f26ahr 4190 19 - - HYPH cord-028721-x6f26ahr 4190 20 Opitz Opitz NNP cord-028721-x6f26ahr 4190 21 syndrome syndrome NN cord-028721-x6f26ahr 4190 22 : : : cord-028721-x6f26ahr 4190 23 mutations mutation NNS cord-028721-x6f26ahr 4190 24 and and CC cord-028721-x6f26ahr 4190 25 metabolic metabolic JJ cord-028721-x6f26ahr 4190 26 morphogenesis morphogenesis NN cord-028721-x6f26ahr 4190 27 Atypical atypical JJ cord-028721-x6f26ahr 4190 28 case case NN cord-028721-x6f26ahr 4190 29 of of IN cord-028721-x6f26ahr 4190 30 Smith Smith NNP cord-028721-x6f26ahr 4190 31 - - HYPH cord-028721-x6f26ahr 4190 32 Lemli Lemli NNP cord-028721-x6f26ahr 4190 33 - - HYPH cord-028721-x6f26ahr 4190 34 Opitz Opitz NNP cord-028721-x6f26ahr 4190 35 syndrome syndrome NN cord-028721-x6f26ahr 4190 36 : : : cord-028721-x6f26ahr 4190 37 implications implication NNS cord-028721-x6f26ahr 4190 38 for for IN cord-028721-x6f26ahr 4190 39 diagnosis diagnosis NN cord-028721-x6f26ahr 4190 40 Genetic genetic JJ cord-028721-x6f26ahr 4190 41 disorders disorder NNS cord-028721-x6f26ahr 4190 42 of of IN cord-028721-x6f26ahr 4190 43 cholesterol cholesterol NN cord-028721-x6f26ahr 4190 44 biosynthesis biosynthesis NN cord-028721-x6f26ahr 4190 45 in in IN cord-028721-x6f26ahr 4190 46 mice mouse NNS cord-028721-x6f26ahr 4190 47 and and CC cord-028721-x6f26ahr 4190 48 humans human NNS cord-028721-x6f26ahr 4190 49 Frequency frequency NN cord-028721-x6f26ahr 4190 50 gradients gradient NNS cord-028721-x6f26ahr 4190 51 of of IN cord-028721-x6f26ahr 4190 52 DHCR7 dhcr7 NN cord-028721-x6f26ahr 4190 53 mutations mutation NNS cord-028721-x6f26ahr 4190 54 in in IN cord-028721-x6f26ahr 4190 55 patients patient NNS cord-028721-x6f26ahr 4190 56 with with IN cord-028721-x6f26ahr 4190 57 Smith Smith NNP cord-028721-x6f26ahr 4190 58 - - HYPH cord-028721-x6f26ahr 4190 59 Lemli Lemli NNP cord-028721-x6f26ahr 4190 60 - - HYPH cord-028721-x6f26ahr 4190 61 Opitz Opitz NNP cord-028721-x6f26ahr 4190 62 syndrome syndrome NN cord-028721-x6f26ahr 4190 63 in in IN cord-028721-x6f26ahr 4190 64 Europe Europe NNP cord-028721-x6f26ahr 4190 65 : : : cord-028721-x6f26ahr 4190 66 evidence evidence NN cord-028721-x6f26ahr 4190 67 for for IN cord-028721-x6f26ahr 4190 68 different different JJ cord-028721-x6f26ahr 4190 69 origins origin NNS cord-028721-x6f26ahr 4190 70 of of IN cord-028721-x6f26ahr 4190 71 common common JJ cord-028721-x6f26ahr 4190 72 mutations mutation NNS cord-028721-x6f26ahr 4191 1 Prenatal prenatal JJ cord-028721-x6f26ahr 4191 2 death death NN cord-028721-x6f26ahr 4191 3 in in IN cord-028721-x6f26ahr 4192 1 Smith Smith NNP cord-028721-x6f26ahr 4192 2 - - HYPH cord-028721-x6f26ahr 4192 3 Lemli Lemli NNP cord-028721-x6f26ahr 4192 4 - - HYPH cord-028721-x6f26ahr 4192 5 Opitz Opitz NNP cord-028721-x6f26ahr 4192 6 / / SYM cord-028721-x6f26ahr 4192 7 RSH RSH NNP cord-028721-x6f26ahr 4192 8 syndrome syndrome NN cord-028721-x6f26ahr 4192 9 Antenatal Antenatal NNP cord-028721-x6f26ahr 4192 10 manifestations manifestation NNS cord-028721-x6f26ahr 4192 11 of of IN cord-028721-x6f26ahr 4192 12 Smith Smith NNP cord-028721-x6f26ahr 4192 13 - - HYPH cord-028721-x6f26ahr 4192 14 Lemli Lemli NNP cord-028721-x6f26ahr 4192 15 - - HYPH cord-028721-x6f26ahr 4192 16 Opitz Opitz NNP cord-028721-x6f26ahr 4192 17 ( ( -LRB- cord-028721-x6f26ahr 4192 18 RSH rsh NN cord-028721-x6f26ahr 4192 19 ) ) -RRB- cord-028721-x6f26ahr 4192 20 syndrome syndrome NN cord-028721-x6f26ahr 4192 21 : : : cord-028721-x6f26ahr 4192 22 a a DT cord-028721-x6f26ahr 4192 23 retrospective retrospective JJ cord-028721-x6f26ahr 4192 24 survey survey NN cord-028721-x6f26ahr 4192 25 of of IN cord-028721-x6f26ahr 4192 26 30 30 CD cord-028721-x6f26ahr 4192 27 cases case NNS cord-028721-x6f26ahr 4192 28 Levels level NNS cord-028721-x6f26ahr 4192 29 of of IN cord-028721-x6f26ahr 4192 30 unconjugated unconjugated JJ cord-028721-x6f26ahr 4192 31 estriol estriol NN cord-028721-x6f26ahr 4192 32 and and CC cord-028721-x6f26ahr 4192 33 other other JJ cord-028721-x6f26ahr 4192 34 maternal maternal JJ cord-028721-x6f26ahr 4192 35 serum serum NN cord-028721-x6f26ahr 4192 36 markers marker NNS cord-028721-x6f26ahr 4192 37 in in IN cord-028721-x6f26ahr 4192 38 pregnancies pregnancy NNS cord-028721-x6f26ahr 4192 39 with with IN cord-028721-x6f26ahr 4192 40 Smith Smith NNP cord-028721-x6f26ahr 4192 41 - - HYPH cord-028721-x6f26ahr 4192 42 Lemli Lemli NNP cord-028721-x6f26ahr 4192 43 - - HYPH cord-028721-x6f26ahr 4192 44 Opitz Opitz NNP cord-028721-x6f26ahr 4192 45 ( ( -LRB- cord-028721-x6f26ahr 4192 46 RSH rsh NN cord-028721-x6f26ahr 4192 47 ) ) -RRB- cord-028721-x6f26ahr 4192 48 syndrome syndrome NN cord-028721-x6f26ahr 4192 49 fetuses fetus NNS cord-028721-x6f26ahr 4192 50 Syndromal Syndromal NNP cord-028721-x6f26ahr 4192 51 ( ( -LRB- cord-028721-x6f26ahr 4192 52 and and CC cord-028721-x6f26ahr 4192 53 nonsyndromal nonsyndromal JJ cord-028721-x6f26ahr 4192 54 ) ) -RRB- cord-028721-x6f26ahr 4192 55 forms form NNS cord-028721-x6f26ahr 4192 56 of of IN cord-028721-x6f26ahr 4192 57 male male JJ cord-028721-x6f26ahr 4192 58 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4192 59 Mutations Mutations NNPS cord-028721-x6f26ahr 4192 60 in in IN cord-028721-x6f26ahr 4192 61 the the DT cord-028721-x6f26ahr 4192 62 delta7-steroid delta7-steroid JJ cord-028721-x6f26ahr 4192 63 reductase reductase NN cord-028721-x6f26ahr 4192 64 gene gene NN cord-028721-x6f26ahr 4192 65 in in IN cord-028721-x6f26ahr 4192 66 patients patient NNS cord-028721-x6f26ahr 4192 67 with with IN cord-028721-x6f26ahr 4192 68 the the DT cord-028721-x6f26ahr 4192 69 Smith Smith NNP cord-028721-x6f26ahr 4192 70 - - HYPH cord-028721-x6f26ahr 4192 71 Lemli Lemli NNP cord-028721-x6f26ahr 4192 72 - - HYPH cord-028721-x6f26ahr 4192 73 Opitz Opitz NNP cord-028721-x6f26ahr 4192 74 syndrome syndrome NN cord-028721-x6f26ahr 4192 75 Molecular molecular JJ cord-028721-x6f26ahr 4192 76 cloning cloning NN cord-028721-x6f26ahr 4192 77 and and CC cord-028721-x6f26ahr 4192 78 expression expression NN cord-028721-x6f26ahr 4192 79 of of IN cord-028721-x6f26ahr 4192 80 the the DT cord-028721-x6f26ahr 4192 81 human human JJ cord-028721-x6f26ahr 4192 82 delta7-sterol delta7-sterol JJ cord-028721-x6f26ahr 4192 83 reductase reductase NN cord-028721-x6f26ahr 4192 84 Mutations Mutations NNPS cord-028721-x6f26ahr 4192 85 in in IN cord-028721-x6f26ahr 4192 86 the the DT cord-028721-x6f26ahr 4192 87 human human JJ cord-028721-x6f26ahr 4192 88 sterol sterol NN cord-028721-x6f26ahr 4192 89 delta7 delta7 NNP cord-028721-x6f26ahr 4192 90 reductase reductase NN cord-028721-x6f26ahr 4192 91 gene gene NN cord-028721-x6f26ahr 4192 92 at at IN cord-028721-x6f26ahr 4192 93 11q12 11q12 CD cord-028721-x6f26ahr 4192 94 - - SYM cord-028721-x6f26ahr 4192 95 13 13 CD cord-028721-x6f26ahr 4192 96 cause cause NN cord-028721-x6f26ahr 4193 1 Smith Smith NNP cord-028721-x6f26ahr 4193 2 - - HYPH cord-028721-x6f26ahr 4193 3 Lemli Lemli NNP cord-028721-x6f26ahr 4193 4 - - HYPH cord-028721-x6f26ahr 4193 5 Opitz Opitz NNP cord-028721-x6f26ahr 4193 6 syndrome syndrome NN cord-028721-x6f26ahr 4194 1 Smith Smith NNP cord-028721-x6f26ahr 4194 2 - - HYPH cord-028721-x6f26ahr 4194 3 Lemli Lemli NNP cord-028721-x6f26ahr 4194 4 - - HYPH cord-028721-x6f26ahr 4194 5 Opitz Opitz NNP cord-028721-x6f26ahr 4194 6 syndrome syndrome NN cord-028721-x6f26ahr 4194 7 is be VBZ cord-028721-x6f26ahr 4194 8 caused cause VBN cord-028721-x6f26ahr 4194 9 by by IN cord-028721-x6f26ahr 4194 10 mutations mutation NNS cord-028721-x6f26ahr 4194 11 in in IN cord-028721-x6f26ahr 4194 12 the the DT cord-028721-x6f26ahr 4194 13 7-dehydrocholesterol 7-dehydrocholesterol CD cord-028721-x6f26ahr 4194 14 reductase reductase NN cord-028721-x6f26ahr 4194 15 gene gene NN cord-028721-x6f26ahr 4194 16 Opitz Opitz NNP cord-028721-x6f26ahr 4194 17 syndrome syndrome NN cord-028721-x6f26ahr 4194 18 : : : cord-028721-x6f26ahr 4194 19 a a DT cord-028721-x6f26ahr 4194 20 multiple multiple JJ cord-028721-x6f26ahr 4194 21 congenital congenital JJ cord-028721-x6f26ahr 4194 22 anomaly anomaly NN cord-028721-x6f26ahr 4194 23 / / SYM cord-028721-x6f26ahr 4194 24 mental mental JJ cord-028721-x6f26ahr 4194 25 retardation retardation NN cord-028721-x6f26ahr 4194 26 syndrome syndrome NN cord-028721-x6f26ahr 4194 27 due due IN cord-028721-x6f26ahr 4194 28 to to IN cord-028721-x6f26ahr 4194 29 an an DT cord-028721-x6f26ahr 4194 30 inborn inborn JJ cord-028721-x6f26ahr 4194 31 error error NN cord-028721-x6f26ahr 4194 32 of of IN cord-028721-x6f26ahr 4194 33 cholesterol cholesterol NN cord-028721-x6f26ahr 4194 34 biosynthesis biosynthesis NNP cord-028721-x6f26ahr 4194 35 Mutation Mutation NNP cord-028721-x6f26ahr 4194 36 analysis analysis NN cord-028721-x6f26ahr 4194 37 and and CC cord-028721-x6f26ahr 4194 38 description description NN cord-028721-x6f26ahr 4194 39 of of IN cord-028721-x6f26ahr 4194 40 sixteen sixteen CD cord-028721-x6f26ahr 4194 41 RSH RSH NNP cord-028721-x6f26ahr 4194 42 / / SYM cord-028721-x6f26ahr 4194 43 Smith Smith NNP cord-028721-x6f26ahr 4194 44 - - HYPH cord-028721-x6f26ahr 4194 45 Lemli Lemli NNP cord-028721-x6f26ahr 4194 46 - - HYPH cord-028721-x6f26ahr 4194 47 Opitz Opitz NNP cord-028721-x6f26ahr 4194 48 syndrome syndrome NN cord-028721-x6f26ahr 4194 49 patients patient NNS cord-028721-x6f26ahr 4194 50 : : : cord-028721-x6f26ahr 4194 51 polymerase polymerase VB cord-028721-x6f26ahr 4194 52 chain chain NN cord-028721-x6f26ahr 4194 53 reaction reaction NN cord-028721-x6f26ahr 4194 54 - - HYPH cord-028721-x6f26ahr 4194 55 based base VBN cord-028721-x6f26ahr 4194 56 assays assay NNS cord-028721-x6f26ahr 4194 57 to to TO cord-028721-x6f26ahr 4194 58 simplify simplify VB cord-028721-x6f26ahr 4194 59 genotyping genotype VBG cord-028721-x6f26ahr 4194 60 Recognition Recognition NNP cord-028721-x6f26ahr 4194 61 of of IN cord-028721-x6f26ahr 4194 62 Smith Smith NNP cord-028721-x6f26ahr 4194 63 - - HYPH cord-028721-x6f26ahr 4194 64 Lemli Lemli NNP cord-028721-x6f26ahr 4194 65 - - HYPH cord-028721-x6f26ahr 4194 66 Opitz Opitz NNP cord-028721-x6f26ahr 4194 67 syndrome syndrome NN cord-028721-x6f26ahr 4194 68 ( ( -LRB- cord-028721-x6f26ahr 4194 69 RSH RSH NNP cord-028721-x6f26ahr 4194 70 ) ) -RRB- cord-028721-x6f26ahr 4194 71 in in IN cord-028721-x6f26ahr 4194 72 the the DT cord-028721-x6f26ahr 4194 73 fetus fetus NN cord-028721-x6f26ahr 4194 74 : : : cord-028721-x6f26ahr 4194 75 utility utility NN cord-028721-x6f26ahr 4194 76 of of IN cord-028721-x6f26ahr 4194 77 ultrasonography ultrasonography NN cord-028721-x6f26ahr 4194 78 and and CC cord-028721-x6f26ahr 4194 79 biochemical biochemical JJ cord-028721-x6f26ahr 4194 80 analysis analysis NN cord-028721-x6f26ahr 4194 81 in in IN cord-028721-x6f26ahr 4194 82 pregnancies pregnancy NNS cord-028721-x6f26ahr 4194 83 with with IN cord-028721-x6f26ahr 4194 84 low low JJ cord-028721-x6f26ahr 4194 85 maternal maternal JJ cord-028721-x6f26ahr 4194 86 serum serum NN cord-028721-x6f26ahr 4195 1 estriol estriol NNP cord-028721-x6f26ahr 4195 2 A a DT cord-028721-x6f26ahr 4195 3 syndrome syndrome NN cord-028721-x6f26ahr 4195 4 of of IN cord-028721-x6f26ahr 4195 5 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4195 6 , , , cord-028721-x6f26ahr 4195 7 Wilms Wilms NNP cord-028721-x6f26ahr 4195 8 ' ' POS cord-028721-x6f26ahr 4195 9 tumor tumor NN cord-028721-x6f26ahr 4195 10 , , , cord-028721-x6f26ahr 4195 11 hypertension hypertension NN cord-028721-x6f26ahr 4195 12 and and CC cord-028721-x6f26ahr 4195 13 degenerative degenerative JJ cord-028721-x6f26ahr 4195 14 renal renal JJ cord-028721-x6f26ahr 4195 15 disease disease NN cord-028721-x6f26ahr 4195 16 Association Association NNP cord-028721-x6f26ahr 4195 17 between between IN cord-028721-x6f26ahr 4195 18 Wilms Wilms NNP cord-028721-x6f26ahr 4195 19 ' ' POS cord-028721-x6f26ahr 4195 20 tumor tumor NN cord-028721-x6f26ahr 4195 21 and and CC cord-028721-x6f26ahr 4195 22 gonadal gonadal NN cord-028721-x6f26ahr 4195 23 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4195 24 Glomerulonephritis Glomerulonephritis NNP cord-028721-x6f26ahr 4195 25 associated associate VBN cord-028721-x6f26ahr 4195 26 with with IN cord-028721-x6f26ahr 4195 27 male male JJ cord-028721-x6f26ahr 4195 28 pseudohermaphroditism pseudohermaphroditism NN cord-028721-x6f26ahr 4195 29 and and CC cord-028721-x6f26ahr 4195 30 nephroblastoma nephroblastoma NNP cord-028721-x6f26ahr 4195 31 Twenty twenty CD cord-028721-x6f26ahr 4195 32 - - HYPH cord-028721-x6f26ahr 4195 33 four four CD cord-028721-x6f26ahr 4195 34 new new JJ cord-028721-x6f26ahr 4195 35 cases case NNS cord-028721-x6f26ahr 4195 36 of of IN cord-028721-x6f26ahr 4195 37 WT1 WT1 HYPH cord-028721-x6f26ahr 4195 38 germline germline NN cord-028721-x6f26ahr 4195 39 mutations mutation NNS cord-028721-x6f26ahr 4195 40 and and CC cord-028721-x6f26ahr 4195 41 review review NN cord-028721-x6f26ahr 4195 42 of of IN cord-028721-x6f26ahr 4195 43 the the DT cord-028721-x6f26ahr 4195 44 literature literature NN cord-028721-x6f26ahr 4196 1 : : : cord-028721-x6f26ahr 4196 2 genotype genotype NN cord-028721-x6f26ahr 4196 3 / / SYM cord-028721-x6f26ahr 4196 4 phenotype phenotype NN cord-028721-x6f26ahr 4196 5 correlations correlation NNS cord-028721-x6f26ahr 4196 6 for for IN cord-028721-x6f26ahr 4197 1 Wilms Wilms NNP cord-028721-x6f26ahr 4197 2 ' ' POS cord-028721-x6f26ahr 4197 3 tumor tumor NN cord-028721-x6f26ahr 4197 4 development development NN cord-028721-x6f26ahr 4197 5 Nephrogenic Nephrogenic NNP cord-028721-x6f26ahr 4197 6 rests rest VBZ cord-028721-x6f26ahr 4197 7 in in IN cord-028721-x6f26ahr 4197 8 Wilms Wilms NNP cord-028721-x6f26ahr 4197 9 ' ' POS cord-028721-x6f26ahr 4197 10 tumor tumor NN cord-028721-x6f26ahr 4197 11 patients patient NNS cord-028721-x6f26ahr 4197 12 with with IN cord-028721-x6f26ahr 4197 13 the the DT cord-028721-x6f26ahr 4197 14 Drash Drash NNP cord-028721-x6f26ahr 4197 15 syndrome syndrome NN cord-028721-x6f26ahr 4197 16 Frasier Frasier NNP cord-028721-x6f26ahr 4197 17 syndrome syndrome NN cord-028721-x6f26ahr 4197 18 , , , cord-028721-x6f26ahr 4197 19 part part NN cord-028721-x6f26ahr 4197 20 of of IN cord-028721-x6f26ahr 4197 21 the the DT cord-028721-x6f26ahr 4197 22 Denys Denys NNP cord-028721-x6f26ahr 4197 23 Drash Drash NNP cord-028721-x6f26ahr 4197 24 continuum continuum NN cord-028721-x6f26ahr 4197 25 or or CC cord-028721-x6f26ahr 4197 26 simply simply RB cord-028721-x6f26ahr 4197 27 a a DT cord-028721-x6f26ahr 4197 28 WT1 WT1 NNP cord-028721-x6f26ahr 4197 29 gene gene NN cord-028721-x6f26ahr 4197 30 associated associate VBN cord-028721-x6f26ahr 4197 31 disorder disorder NN cord-028721-x6f26ahr 4197 32 of of IN cord-028721-x6f26ahr 4197 33 intersex intersex NN cord-028721-x6f26ahr 4197 34 and and CC cord-028721-x6f26ahr 4197 35 nephropathy nephropathy NN cord-028721-x6f26ahr 4197 36 ? ? . cord-028721-x6f26ahr 4198 1 Frasier Frasier NNP cord-028721-x6f26ahr 4198 2 syndrome syndrome NN cord-028721-x6f26ahr 4198 3 : : : cord-028721-x6f26ahr 4198 4 a a DT cord-028721-x6f26ahr 4198 5 rare rare JJ cord-028721-x6f26ahr 4198 6 syndrome syndrome NN cord-028721-x6f26ahr 4198 7 with with IN cord-028721-x6f26ahr 4198 8 WT1 wt1 JJ cord-028721-x6f26ahr 4198 9 gene gene NN cord-028721-x6f26ahr 4198 10 mutation mutation NN cord-028721-x6f26ahr 4198 11 in in IN cord-028721-x6f26ahr 4198 12 pediatric pediatric JJ cord-028721-x6f26ahr 4198 13 urology urology NNP cord-028721-x6f26ahr 4198 14 Mutation Mutation NNP cord-028721-x6f26ahr 4198 15 in in IN cord-028721-x6f26ahr 4198 16 the the DT cord-028721-x6f26ahr 4198 17 PAX6 PAX6 NNP cord-028721-x6f26ahr 4198 18 gene gene NN cord-028721-x6f26ahr 4198 19 in in IN cord-028721-x6f26ahr 4198 20 twenty twenty CD cord-028721-x6f26ahr 4198 21 patients patient NNS cord-028721-x6f26ahr 4198 22 with with IN cord-028721-x6f26ahr 4198 23 aniridia aniridia NNP cord-028721-x6f26ahr 4198 24 WAGR WAGR NNP cord-028721-x6f26ahr 4198 25 syndrome syndrome NN cord-028721-x6f26ahr 4198 26 : : : cord-028721-x6f26ahr 4198 27 a a DT cord-028721-x6f26ahr 4198 28 clinical clinical JJ cord-028721-x6f26ahr 4198 29 review review NN cord-028721-x6f26ahr 4198 30 of of IN cord-028721-x6f26ahr 4198 31 54 54 CD cord-028721-x6f26ahr 4198 32 cases case NNS cord-028721-x6f26ahr 4199 1 The the DT cord-028721-x6f26ahr 4199 2 G g NN cord-028721-x6f26ahr 4199 3 syndrome syndrome NN cord-028721-x6f26ahr 4199 4 of of IN cord-028721-x6f26ahr 4199 5 multiple multiple JJ cord-028721-x6f26ahr 4199 6 congenital congenital JJ cord-028721-x6f26ahr 4199 7 anomalies anomaly NNS cord-028721-x6f26ahr 4200 1 The the DT cord-028721-x6f26ahr 4200 2 BBB BBB NNP cord-028721-x6f26ahr 4200 3 syndrome syndrome NN cord-028721-x6f26ahr 4200 4 : : : cord-028721-x6f26ahr 4200 5 familial familial JJ cord-028721-x6f26ahr 4200 6 telecanthus telecanthus NN cord-028721-x6f26ahr 4200 7 with with IN cord-028721-x6f26ahr 4200 8 associated associated JJ cord-028721-x6f26ahr 4200 9 congenital congenital JJ cord-028721-x6f26ahr 4200 10 anomalies anomaly NNS cord-028721-x6f26ahr 4200 11 Mig12 Mig12 NNP cord-028721-x6f26ahr 4200 12 , , , cord-028721-x6f26ahr 4200 13 a a DT cord-028721-x6f26ahr 4200 14 novel novel JJ cord-028721-x6f26ahr 4200 15 Opitz Opitz NNP cord-028721-x6f26ahr 4200 16 syndrome syndrome NN cord-028721-x6f26ahr 4200 17 gene gene NN cord-028721-x6f26ahr 4200 18 product product NN cord-028721-x6f26ahr 4200 19 partner partner NN cord-028721-x6f26ahr 4200 20 , , , cord-028721-x6f26ahr 4200 21 is be VBZ cord-028721-x6f26ahr 4200 22 expressed express VBN cord-028721-x6f26ahr 4200 23 in in IN cord-028721-x6f26ahr 4200 24 the the DT cord-028721-x6f26ahr 4200 25 embryonic embryonic JJ cord-028721-x6f26ahr 4200 26 ventral ventral JJ cord-028721-x6f26ahr 4200 27 midline midline NN cord-028721-x6f26ahr 4200 28 and and CC cord-028721-x6f26ahr 4200 29 co co NNS cord-028721-x6f26ahr 4200 30 - - VBN cord-028721-x6f26ahr 4200 31 operates operate VBZ cord-028721-x6f26ahr 4200 32 with with IN cord-028721-x6f26ahr 4200 33 Mid1 Mid1 NNP cord-028721-x6f26ahr 4200 34 to to TO cord-028721-x6f26ahr 4200 35 bundle bundle VB cord-028721-x6f26ahr 4200 36 and and CC cord-028721-x6f26ahr 4200 37 stabilize stabilize VB cord-028721-x6f26ahr 4200 38 microtubules microtubule NNS cord-028721-x6f26ahr 4200 39 Xlinked Xlinked NNP cord-028721-x6f26ahr 4200 40 Opitz Opitz NNP cord-028721-x6f26ahr 4200 41 G G NNP cord-028721-x6f26ahr 4200 42 / / SYM cord-028721-x6f26ahr 4200 43 BBB BBB NNP cord-028721-x6f26ahr 4200 44 syndrome syndrome NN cord-028721-x6f26ahr 4200 45 : : : cord-028721-x6f26ahr 4200 46 identifi identifi NNP cord-028721-x6f26ahr 4200 47 cation cation NNP cord-028721-x6f26ahr 4200 48 of of IN cord-028721-x6f26ahr 4200 49 a a DT cord-028721-x6f26ahr 4200 50 novel novel JJ cord-028721-x6f26ahr 4200 51 mutation mutation NN cord-028721-x6f26ahr 4200 52 and and CC cord-028721-x6f26ahr 4200 53 prenatal prenatal JJ cord-028721-x6f26ahr 4200 54 diagnosis diagnosis NN cord-028721-x6f26ahr 4200 55 in in IN cord-028721-x6f26ahr 4200 56 a a DT cord-028721-x6f26ahr 4200 57 Korean korean JJ cord-028721-x6f26ahr 4200 58 family family NN cord-028721-x6f26ahr 4200 59 Genetic genetic JJ cord-028721-x6f26ahr 4200 60 study study NN cord-028721-x6f26ahr 4200 61 of of IN cord-028721-x6f26ahr 4200 62 SOX9 SOX9 NNP cord-028721-x6f26ahr 4200 63 in in IN cord-028721-x6f26ahr 4200 64 a a DT cord-028721-x6f26ahr 4200 65 case case NN cord-028721-x6f26ahr 4200 66 of of IN cord-028721-x6f26ahr 4200 67 campomelic campomelic JJ cord-028721-x6f26ahr 4200 68 dysplasia dysplasia NNP cord-028721-x6f26ahr 4200 69 Molecularclinical Molecularclinical NNP cord-028721-x6f26ahr 4200 70 spectrum spectrum NN cord-028721-x6f26ahr 4200 71 of of IN cord-028721-x6f26ahr 4201 1 the the DT cord-028721-x6f26ahr 4201 2 ATR ATR NNP cord-028721-x6f26ahr 4201 3 - - HYPH cord-028721-x6f26ahr 4201 4 X X NNP cord-028721-x6f26ahr 4201 5 syndrome syndrome NN cord-028721-x6f26ahr 4201 6 A a DT cord-028721-x6f26ahr 4201 7 new new JJ cord-028721-x6f26ahr 4201 8 detection detection NN cord-028721-x6f26ahr 4201 9 method method NN cord-028721-x6f26ahr 4201 10 for for IN cord-028721-x6f26ahr 4201 11 ATRX ATRX NNP cord-028721-x6f26ahr 4201 12 gene gene NN cord-028721-x6f26ahr 4201 13 mutations mutation NNS cord-028721-x6f26ahr 4201 14 using use VBG cord-028721-x6f26ahr 4201 15 a a DT cord-028721-x6f26ahr 4201 16 mismatch mismatch NN cord-028721-x6f26ahr 4201 17 - - HYPH cord-028721-x6f26ahr 4201 18 specifi specifi NN cord-028721-x6f26ahr 4201 19 c c NN cord-028721-x6f26ahr 4201 20 endonuclease endonuclease NN cord-028721-x6f26ahr 4201 21 Prenatal prenatal JJ cord-028721-x6f26ahr 4201 22 diagnosis diagnosis NN cord-028721-x6f26ahr 4201 23 of of IN cord-028721-x6f26ahr 4201 24 ATR ATR NNP cord-028721-x6f26ahr 4201 25 - - HYPH cord-028721-x6f26ahr 4201 26 X X NNP cord-028721-x6f26ahr 4201 27 syndrome syndrome NN cord-028721-x6f26ahr 4201 28 in in IN cord-028721-x6f26ahr 4201 29 a a DT cord-028721-x6f26ahr 4201 30 fetus fetus NN cord-028721-x6f26ahr 4201 31 with with IN cord-028721-x6f26ahr 4201 32 a a DT cord-028721-x6f26ahr 4201 33 new new JJ cord-028721-x6f26ahr 4201 34 G g NN cord-028721-x6f26ahr 4201 35 > > XX cord-028721-x6f26ahr 4201 36 T t NN cord-028721-x6f26ahr 4201 37 splicing splicing NN cord-028721-x6f26ahr 4201 38 mutation mutation NN cord-028721-x6f26ahr 4201 39 in in IN cord-028721-x6f26ahr 4201 40 the the DT cord-028721-x6f26ahr 4201 41 XNP XNP NNP cord-028721-x6f26ahr 4201 42 / / SYM cord-028721-x6f26ahr 4201 43 ATR ATR NNP cord-028721-x6f26ahr 4201 44 - - HYPH cord-028721-x6f26ahr 4201 45 X x NN cord-028721-x6f26ahr 4201 46 gene gene NN cord-028721-x6f26ahr 4201 47 Testicular Testicular NNP cord-028721-x6f26ahr 4201 48 biopsy biopsy NN cord-028721-x6f26ahr 4201 49 , , , cord-028721-x6f26ahr 4201 50 its -PRON- PRP$ cord-028721-x6f26ahr 4201 51 value value NN cord-028721-x6f26ahr 4201 52 in in IN cord-028721-x6f26ahr 4201 53 male male JJ cord-028721-x6f26ahr 4201 54 sterility sterility NN cord-028721-x6f26ahr 4201 55 Testicular Testicular NNP cord-028721-x6f26ahr 4201 56 biopsy biopsy NN cord-028721-x6f26ahr 4201 57 . . . cord-028721-x6f26ahr 4202 1 Further further JJ cord-028721-x6f26ahr 4202 2 studies study NNS cord-028721-x6f26ahr 4202 3 in in IN cord-028721-x6f26ahr 4202 4 male male JJ cord-028721-x6f26ahr 4202 5 infertility infertility NN cord-028721-x6f26ahr 4202 6 Interpretation Interpretation NNP cord-028721-x6f26ahr 4202 7 of of IN cord-028721-x6f26ahr 4202 8 testicular testicular NNP cord-028721-x6f26ahr 4202 9 biopsy biopsy NN cord-028721-x6f26ahr 4202 10 Testicular Testicular NNP cord-028721-x6f26ahr 4202 11 biopsy biopsy NN cord-028721-x6f26ahr 4202 12 in in IN cord-028721-x6f26ahr 4202 13 the the DT cord-028721-x6f26ahr 4202 14 evolution evolution NN cord-028721-x6f26ahr 4202 15 of of IN cord-028721-x6f26ahr 4202 16 male male JJ cord-028721-x6f26ahr 4202 17 infertility infertility NN cord-028721-x6f26ahr 4202 18 Testicular Testicular NNP cord-028721-x6f26ahr 4202 19 causes cause NNS cord-028721-x6f26ahr 4202 20 of of IN cord-028721-x6f26ahr 4202 21 infertility infertility NN cord-028721-x6f26ahr 4202 22 Pretesticular Pretesticular NNP cord-028721-x6f26ahr 4202 23 causes cause NNS cord-028721-x6f26ahr 4202 24 of of IN cord-028721-x6f26ahr 4202 25 infertility infertility NN cord-028721-x6f26ahr 4203 1 A a DT cord-028721-x6f26ahr 4203 2 quantitative quantitative JJ cord-028721-x6f26ahr 4203 3 approach approach NN cord-028721-x6f26ahr 4203 4 to to IN cord-028721-x6f26ahr 4203 5 the the DT cord-028721-x6f26ahr 4203 6 classifi classifi NNP cord-028721-x6f26ahr 4203 7 cation cation NNP cord-028721-x6f26ahr 4203 8 of of IN cord-028721-x6f26ahr 4203 9 hypospermatogenesis hypospermatogenesis NNP cord-028721-x6f26ahr 4203 10 in in IN cord-028721-x6f26ahr 4203 11 testicular testicular JJ cord-028721-x6f26ahr 4203 12 biopsies biopsy NNS cord-028721-x6f26ahr 4203 13 for for IN cord-028721-x6f26ahr 4203 14 infertility infertility NN cord-028721-x6f26ahr 4203 15 Testicular Testicular NNP cord-028721-x6f26ahr 4203 16 biopsy biopsy NN cord-028721-x6f26ahr 4203 17 for for IN cord-028721-x6f26ahr 4203 18 infertility infertility NN cord-028721-x6f26ahr 4203 19 : : : cord-028721-x6f26ahr 4203 20 a a DT cord-028721-x6f26ahr 4203 21 review review NN cord-028721-x6f26ahr 4203 22 of of IN cord-028721-x6f26ahr 4203 23 sixty sixty CD cord-028721-x6f26ahr 4203 24 - - HYPH cord-028721-x6f26ahr 4203 25 eight eight CD cord-028721-x6f26ahr 4203 26 cases case NNS cord-028721-x6f26ahr 4203 27 with with IN cord-028721-x6f26ahr 4203 28 a a DT cord-028721-x6f26ahr 4203 29 simplifi simplifi NNP cord-028721-x6f26ahr 4203 30 ed ed NNP cord-028721-x6f26ahr 4203 31 histologic histologic JJ cord-028721-x6f26ahr 4203 32 classifi classifi NNP cord-028721-x6f26ahr 4203 33 cation cation NN cord-028721-x6f26ahr 4203 34 of of IN cord-028721-x6f26ahr 4203 35 lesions lesion NNS cord-028721-x6f26ahr 4203 36 Testicular Testicular NNP cord-028721-x6f26ahr 4203 37 biopsy biopsy NN cord-028721-x6f26ahr 4203 38 in in IN cord-028721-x6f26ahr 4203 39 azoospermia azoospermia NN cord-028721-x6f26ahr 4203 40 : : : cord-028721-x6f26ahr 4203 41 a a DT cord-028721-x6f26ahr 4203 42 review review NN cord-028721-x6f26ahr 4203 43 of of IN cord-028721-x6f26ahr 4203 44 the the DT cord-028721-x6f26ahr 4203 45 last last JJ cord-028721-x6f26ahr 4203 46 ten ten CD cord-028721-x6f26ahr 4203 47 years year NNS cord-028721-x6f26ahr 4203 48 . . . cord-028721-x6f26ahr 4204 1 Experience experience NN cord-028721-x6f26ahr 4204 2 of of IN cord-028721-x6f26ahr 4204 3 over over IN cord-028721-x6f26ahr 4204 4 800 800 CD cord-028721-x6f26ahr 4204 5 cases case NNS cord-028721-x6f26ahr 4204 6 Posttesticular Posttesticular NNP cord-028721-x6f26ahr 4204 7 causes cause NNS cord-028721-x6f26ahr 4204 8 of of IN cord-028721-x6f26ahr 4204 9 infertility infertility NN cord-028721-x6f26ahr 4204 10 Histopathology Histopathology NNP cord-028721-x6f26ahr 4204 11 and and CC cord-028721-x6f26ahr 4204 12 ultrastructure ultrastructure NN cord-028721-x6f26ahr 4204 13 of of IN cord-028721-x6f26ahr 4204 14 meiotic meiotic JJ cord-028721-x6f26ahr 4204 15 arrest arrest NN cord-028721-x6f26ahr 4204 16 in in IN cord-028721-x6f26ahr 4204 17 human human JJ cord-028721-x6f26ahr 4204 18 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4204 19 Refl Refl NNP cord-028721-x6f26ahr 4204 20 ections ection NNS cord-028721-x6f26ahr 4204 21 on on IN cord-028721-x6f26ahr 4204 22 testicular testicular JJ cord-028721-x6f26ahr 4204 23 biopsy biopsy NN cord-028721-x6f26ahr 4204 24 Testicular Testicular NNP cord-028721-x6f26ahr 4204 25 biopsy biopsy NN cord-028721-x6f26ahr 4204 26 in in IN cord-028721-x6f26ahr 4204 27 evaluation evaluation NN cord-028721-x6f26ahr 4204 28 of of IN cord-028721-x6f26ahr 4204 29 male male JJ cord-028721-x6f26ahr 4204 30 infertility infertility NN cord-028721-x6f26ahr 4204 31 Testicular Testicular NNP cord-028721-x6f26ahr 4204 32 biopsy biopsy NN cord-028721-x6f26ahr 4204 33 in in IN cord-028721-x6f26ahr 4204 34 the the DT cord-028721-x6f26ahr 4204 35 study study NN cord-028721-x6f26ahr 4204 36 of of IN cord-028721-x6f26ahr 4204 37 male male JJ cord-028721-x6f26ahr 4204 38 infertility infertility NN cord-028721-x6f26ahr 4204 39 . . . cord-028721-x6f26ahr 4205 1 Its -PRON- PRP$ cord-028721-x6f26ahr 4205 2 current current JJ cord-028721-x6f26ahr 4205 3 usefulness usefulness NN cord-028721-x6f26ahr 4205 4 , , , cord-028721-x6f26ahr 4205 5 histologic histologic JJ cord-028721-x6f26ahr 4205 6 techniques technique NNS cord-028721-x6f26ahr 4205 7 , , , cord-028721-x6f26ahr 4205 8 and and CC cord-028721-x6f26ahr 4205 9 prospects prospect NNS cord-028721-x6f26ahr 4205 10 for for IN cord-028721-x6f26ahr 4205 11 the the DT cord-028721-x6f26ahr 4205 12 future future JJ cord-028721-x6f26ahr 4205 13 Testicular Testicular NNP cord-028721-x6f26ahr 4205 14 biopsy biopsy NN cord-028721-x6f26ahr 4205 15 of of IN cord-028721-x6f26ahr 4205 16 azoospermic azoospermic NNP cord-028721-x6f26ahr 4205 17 men man NNS cord-028721-x6f26ahr 4205 18 with with IN cord-028721-x6f26ahr 4205 19 vas vas NNP cord-028721-x6f26ahr 4205 20 deferens deferens NNP cord-028721-x6f26ahr 4205 21 malformation malformation NN cord-028721-x6f26ahr 4205 22 using use VBG cord-028721-x6f26ahr 4205 23 two two CD cord-028721-x6f26ahr 4205 24 different different JJ cord-028721-x6f26ahr 4205 25 techniques technique NNS cord-028721-x6f26ahr 4205 26 Ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4205 27 studies study NNS cord-028721-x6f26ahr 4205 28 on on IN cord-028721-x6f26ahr 4205 29 testicular testicular JJ cord-028721-x6f26ahr 4205 30 biopsies biopsy NNS cord-028721-x6f26ahr 4205 31 from from IN cord-028721-x6f26ahr 4205 32 eighteen eighteen CD cord-028721-x6f26ahr 4205 33 cases case NNS cord-028721-x6f26ahr 4205 34 of of IN cord-028721-x6f26ahr 4205 35 hypospermatogenesis hypospermatogenesis NN cord-028721-x6f26ahr 4205 36 Serum serum NN cord-028721-x6f26ahr 4205 37 and and CC cord-028721-x6f26ahr 4205 38 seminal seminal JJ cord-028721-x6f26ahr 4205 39 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 4205 40 in in IN cord-028721-x6f26ahr 4205 41 normal normal JJ cord-028721-x6f26ahr 4205 42 and and CC cord-028721-x6f26ahr 4205 43 infertile infertile JJ cord-028721-x6f26ahr 4205 44 men man NNS cord-028721-x6f26ahr 4205 45 : : : cord-028721-x6f26ahr 4205 46 correlations correlation NNS cord-028721-x6f26ahr 4205 47 with with IN cord-028721-x6f26ahr 4205 48 sperm sperm NN cord-028721-x6f26ahr 4205 49 count count NN cord-028721-x6f26ahr 4205 50 , , , cord-028721-x6f26ahr 4205 51 prolactinemia prolactinemia NNP cord-028721-x6f26ahr 4205 52 , , , cord-028721-x6f26ahr 4205 53 and and CC cord-028721-x6f26ahr 4205 54 seminal seminal JJ cord-028721-x6f26ahr 4205 55 prolactin prolactin NN cord-028721-x6f26ahr 4206 1 The the DT cord-028721-x6f26ahr 4206 2 relationship relationship NN cord-028721-x6f26ahr 4206 3 of of IN cord-028721-x6f26ahr 4206 4 biopsy biopsy NN cord-028721-x6f26ahr 4206 5 evaluations evaluation NNS cord-028721-x6f26ahr 4206 6 and and CC cord-028721-x6f26ahr 4206 7 testicular testicular JJ cord-028721-x6f26ahr 4206 8 measurements measurement NNS cord-028721-x6f26ahr 4206 9 to to IN cord-028721-x6f26ahr 4206 10 overall overall JJ cord-028721-x6f26ahr 4206 11 daily daily JJ cord-028721-x6f26ahr 4206 12 sperm sperm NN cord-028721-x6f26ahr 4206 13 production production NN cord-028721-x6f26ahr 4206 14 in in IN cord-028721-x6f26ahr 4206 15 human human JJ cord-028721-x6f26ahr 4206 16 testes testis NNS cord-028721-x6f26ahr 4207 1 The the DT cord-028721-x6f26ahr 4207 2 relationship relationship NN cord-028721-x6f26ahr 4207 3 between between IN cord-028721-x6f26ahr 4207 4 germinal germinal JJ cord-028721-x6f26ahr 4207 5 cells cell NNS cord-028721-x6f26ahr 4207 6 and and CC cord-028721-x6f26ahr 4207 7 serum serum NN cord-028721-x6f26ahr 4207 8 FSH fsh NN cord-028721-x6f26ahr 4207 9 levels level NNS cord-028721-x6f26ahr 4207 10 in in IN cord-028721-x6f26ahr 4207 11 males male NNS cord-028721-x6f26ahr 4207 12 with with IN cord-028721-x6f26ahr 4207 13 infertility infertility NN cord-028721-x6f26ahr 4207 14 Inhibin Inhibin NNP cord-028721-x6f26ahr 4207 15 B B NNP cord-028721-x6f26ahr 4207 16 as as IN cord-028721-x6f26ahr 4207 17 a a DT cord-028721-x6f26ahr 4207 18 serum serum NN cord-028721-x6f26ahr 4207 19 marker marker NN cord-028721-x6f26ahr 4207 20 of of IN cord-028721-x6f26ahr 4207 21 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4207 22 : : : cord-028721-x6f26ahr 4207 23 correlation correlation NN cord-028721-x6f26ahr 4207 24 to to IN cord-028721-x6f26ahr 4207 25 differences difference NNS cord-028721-x6f26ahr 4207 26 in in IN cord-028721-x6f26ahr 4207 27 sperm sperm NN cord-028721-x6f26ahr 4207 28 concentration concentration NN cord-028721-x6f26ahr 4207 29 and and CC cord-028721-x6f26ahr 4207 30 follicle follicle NN cord-028721-x6f26ahr 4207 31 - - HYPH cord-028721-x6f26ahr 4207 32 stimulating stimulate VBG cord-028721-x6f26ahr 4207 33 hormone hormone NN cord-028721-x6f26ahr 4207 34 levels level NNS cord-028721-x6f26ahr 4208 1 Danish danish JJ cord-028721-x6f26ahr 4208 2 men man NNS cord-028721-x6f26ahr 4209 1 Inhibin Inhibin NNP cord-028721-x6f26ahr 4209 2 B B NNP cord-028721-x6f26ahr 4209 3 is be VBZ cord-028721-x6f26ahr 4209 4 a a DT cord-028721-x6f26ahr 4209 5 better well JJR cord-028721-x6f26ahr 4209 6 marker marker NN cord-028721-x6f26ahr 4209 7 of of IN cord-028721-x6f26ahr 4209 8 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4209 9 than than IN cord-028721-x6f26ahr 4209 10 other other JJ cord-028721-x6f26ahr 4209 11 hormones hormone NNS cord-028721-x6f26ahr 4209 12 in in IN cord-028721-x6f26ahr 4209 13 the the DT cord-028721-x6f26ahr 4209 14 evaluation evaluation NN cord-028721-x6f26ahr 4209 15 of of IN cord-028721-x6f26ahr 4209 16 male male JJ cord-028721-x6f26ahr 4209 17 factor factor NN cord-028721-x6f26ahr 4209 18 infertility infertility NN cord-028721-x6f26ahr 4210 1 The the DT cord-028721-x6f26ahr 4210 2 correlation correlation NN cord-028721-x6f26ahr 4210 3 between between IN cord-028721-x6f26ahr 4210 4 sperm sperm NN cord-028721-x6f26ahr 4210 5 count count NN cord-028721-x6f26ahr 4210 6 and and CC cord-028721-x6f26ahr 4210 7 testicular testicular JJ cord-028721-x6f26ahr 4210 8 biopsy biopsy NN cord-028721-x6f26ahr 4210 9 using use VBG cord-028721-x6f26ahr 4210 10 a a DT cord-028721-x6f26ahr 4210 11 new new JJ cord-028721-x6f26ahr 4210 12 scoring scoring NN cord-028721-x6f26ahr 4210 13 system system NN cord-028721-x6f26ahr 4210 14 Testicular Testicular NNP cord-028721-x6f26ahr 4210 15 biopsy biopsy NN cord-028721-x6f26ahr 4210 16 score score NN cord-028721-x6f26ahr 4210 17 count count NN cord-028721-x6f26ahr 4211 1 -a -a : cord-028721-x6f26ahr 4211 2 method method NN cord-028721-x6f26ahr 4211 3 for for IN cord-028721-x6f26ahr 4211 4 registration registration NN cord-028721-x6f26ahr 4211 5 of of IN cord-028721-x6f26ahr 4211 6 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4211 7 in in IN cord-028721-x6f26ahr 4211 8 human human JJ cord-028721-x6f26ahr 4211 9 testes testis NNS cord-028721-x6f26ahr 4211 10 : : : cord-028721-x6f26ahr 4211 11 Normal normal JJ cord-028721-x6f26ahr 4211 12 values value NNS cord-028721-x6f26ahr 4211 13 and and CC cord-028721-x6f26ahr 4211 14 results result NNS cord-028721-x6f26ahr 4211 15 in in IN cord-028721-x6f26ahr 4211 16 335 335 CD cord-028721-x6f26ahr 4211 17 hypogonadal hypogonadal JJ cord-028721-x6f26ahr 4211 18 males male NNS cord-028721-x6f26ahr 4211 19 Statistical statistical JJ cord-028721-x6f26ahr 4211 20 study study NN cord-028721-x6f26ahr 4211 21 of of IN cord-028721-x6f26ahr 4211 22 a a DT cord-028721-x6f26ahr 4211 23 semiquantitative semiquantitative JJ cord-028721-x6f26ahr 4211 24 evaluation evaluation NN cord-028721-x6f26ahr 4211 25 of of IN cord-028721-x6f26ahr 4211 26 testicular testicular JJ cord-028721-x6f26ahr 4211 27 biopsies biopsy NNS cord-028721-x6f26ahr 4212 1 A a DT cord-028721-x6f26ahr 4212 2 method method NN cord-028721-x6f26ahr 4212 3 for for IN cord-028721-x6f26ahr 4212 4 quantitative quantitative JJ cord-028721-x6f26ahr 4212 5 analysis analysis NN cord-028721-x6f26ahr 4212 6 of of IN cord-028721-x6f26ahr 4212 7 human human JJ cord-028721-x6f26ahr 4212 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 4212 9 epithelium epithelium NN cord-028721-x6f26ahr 4212 10 Quantitation Quantitation NNP cord-028721-x6f26ahr 4212 11 of of IN cord-028721-x6f26ahr 4212 12 the the DT cord-028721-x6f26ahr 4212 13 cells cell NNS cord-028721-x6f26ahr 4212 14 of of IN cord-028721-x6f26ahr 4212 15 the the DT cord-028721-x6f26ahr 4212 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 4212 17 epithelium epithelium NN cord-028721-x6f26ahr 4212 18 of of IN cord-028721-x6f26ahr 4212 19 human human JJ cord-028721-x6f26ahr 4212 20 testis testis NN cord-028721-x6f26ahr 4212 21 employing employ VBG cord-028721-x6f26ahr 4212 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 4212 23 cells cell NNS cord-028721-x6f26ahr 4212 24 as as IN cord-028721-x6f26ahr 4212 25 a a DT cord-028721-x6f26ahr 4212 26 constant constant JJ cord-028721-x6f26ahr 4212 27 Quantifi Quantifi NNP cord-028721-x6f26ahr 4212 28 cation cation NN cord-028721-x6f26ahr 4212 29 of of IN cord-028721-x6f26ahr 4212 30 human human JJ cord-028721-x6f26ahr 4212 31 seminiferous seminiferous JJ cord-028721-x6f26ahr 4212 32 epithelium epithelium NN cord-028721-x6f26ahr 4212 33 . . . cord-028721-x6f26ahr 4213 1 III III NNP cord-028721-x6f26ahr 4213 2 Histological Histological NNP cord-028721-x6f26ahr 4213 3 studies study NNS cord-028721-x6f26ahr 4213 4 in in IN cord-028721-x6f26ahr 4213 5 44 44 CD cord-028721-x6f26ahr 4213 6 infertile infertile JJ cord-028721-x6f26ahr 4213 7 men man NNS cord-028721-x6f26ahr 4213 8 with with IN cord-028721-x6f26ahr 4213 9 normal normal JJ cord-028721-x6f26ahr 4213 10 chromosome chromosome NN cord-028721-x6f26ahr 4213 11 complements complement VBZ cord-028721-x6f26ahr 4213 12 Quantifi Quantifi NNP cord-028721-x6f26ahr 4213 13 cation cation NN cord-028721-x6f26ahr 4213 14 of of IN cord-028721-x6f26ahr 4213 15 human human JJ cord-028721-x6f26ahr 4213 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 4213 17 epithelium epithelium NN cord-028721-x6f26ahr 4213 18 . . . cord-028721-x6f26ahr 4214 1 4 4 LS cord-028721-x6f26ahr 4214 2 . . . cord-028721-x6f26ahr 4215 1 Histological Histological NNP cord-028721-x6f26ahr 4215 2 studies study NNS cord-028721-x6f26ahr 4215 3 in in IN cord-028721-x6f26ahr 4215 4 17 17 CD cord-028721-x6f26ahr 4215 5 men man NNS cord-028721-x6f26ahr 4215 6 with with IN cord-028721-x6f26ahr 4215 7 numerical numerical JJ cord-028721-x6f26ahr 4215 8 and and CC cord-028721-x6f26ahr 4215 9 structural structural JJ cord-028721-x6f26ahr 4215 10 autosomal autosomal JJ cord-028721-x6f26ahr 4215 11 aberrations aberration NNS cord-028721-x6f26ahr 4215 12 Quantifi Quantifi NNP cord-028721-x6f26ahr 4215 13 cation cation NN cord-028721-x6f26ahr 4215 14 of of IN cord-028721-x6f26ahr 4215 15 human human JJ cord-028721-x6f26ahr 4215 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 4215 17 epithelium epithelium NN cord-028721-x6f26ahr 4215 18 . . . cord-028721-x6f26ahr 4216 1 I -PRON- PRP cord-028721-x6f26ahr 4217 1 Histological Histological NNP cord-028721-x6f26ahr 4217 2 studies study NNS cord-028721-x6f26ahr 4217 3 in in IN cord-028721-x6f26ahr 4217 4 twenty twenty CD cord-028721-x6f26ahr 4217 5 - - HYPH cord-028721-x6f26ahr 4217 6 one one CD cord-028721-x6f26ahr 4217 7 fertile fertile JJ cord-028721-x6f26ahr 4217 8 men man NNS cord-028721-x6f26ahr 4217 9 with with IN cord-028721-x6f26ahr 4217 10 normal normal JJ cord-028721-x6f26ahr 4217 11 chromosome chromosome NN cord-028721-x6f26ahr 4217 12 complements complement VBZ cord-028721-x6f26ahr 4217 13 Quantitative quantitative JJ cord-028721-x6f26ahr 4217 14 analysis analysis NN cord-028721-x6f26ahr 4217 15 of of IN cord-028721-x6f26ahr 4217 16 the the DT cord-028721-x6f26ahr 4217 17 seminiferous seminiferous JJ cord-028721-x6f26ahr 4217 18 epithelium epithelium NN cord-028721-x6f26ahr 4217 19 in in IN cord-028721-x6f26ahr 4217 20 human human JJ cord-028721-x6f26ahr 4217 21 testicular testicular JJ cord-028721-x6f26ahr 4217 22 biopsies biopsy NNS cord-028721-x6f26ahr 4217 23 , , , cord-028721-x6f26ahr 4217 24 and and CC cord-028721-x6f26ahr 4217 25 the the DT cord-028721-x6f26ahr 4217 26 relation relation NN cord-028721-x6f26ahr 4217 27 of of IN cord-028721-x6f26ahr 4217 28 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4217 29 to to IN cord-028721-x6f26ahr 4217 30 sperm sperm NN cord-028721-x6f26ahr 4217 31 density density NN cord-028721-x6f26ahr 4217 32 Quantifi Quantifi NNP cord-028721-x6f26ahr 4217 33 cation cation NN cord-028721-x6f26ahr 4217 34 of of IN cord-028721-x6f26ahr 4217 35 the the DT cord-028721-x6f26ahr 4217 36 human human JJ cord-028721-x6f26ahr 4217 37 Sertoli Sertoli NNP cord-028721-x6f26ahr 4217 38 cell cell NN cord-028721-x6f26ahr 4217 39 population population NN cord-028721-x6f26ahr 4217 40 : : : cord-028721-x6f26ahr 4217 41 its -PRON- PRP$ cord-028721-x6f26ahr 4217 42 distribution distribution NN cord-028721-x6f26ahr 4217 43 , , , cord-028721-x6f26ahr 4217 44 relation relation NN cord-028721-x6f26ahr 4217 45 to to IN cord-028721-x6f26ahr 4217 46 germ germ NN cord-028721-x6f26ahr 4217 47 cell cell NN cord-028721-x6f26ahr 4217 48 numbers number NNS cord-028721-x6f26ahr 4217 49 , , , cord-028721-x6f26ahr 4217 50 and and CC cord-028721-x6f26ahr 4217 51 age age NN cord-028721-x6f26ahr 4217 52 related relate VBN cord-028721-x6f26ahr 4217 53 decline decline NN cord-028721-x6f26ahr 4217 54 Quantitation Quantitation NNP cord-028721-x6f26ahr 4217 55 of of IN cord-028721-x6f26ahr 4217 56 Leydig Leydig NNP cord-028721-x6f26ahr 4217 57 cells cell NNS cord-028721-x6f26ahr 4217 58 in in IN cord-028721-x6f26ahr 4217 59 testicular testicular JJ cord-028721-x6f26ahr 4217 60 biopsies biopsy NNS cord-028721-x6f26ahr 4217 61 of of IN cord-028721-x6f26ahr 4217 62 oligospermic oligospermic JJ cord-028721-x6f26ahr 4217 63 men man NNS cord-028721-x6f26ahr 4217 64 with with IN cord-028721-x6f26ahr 4217 65 varicocele varicocele NN cord-028721-x6f26ahr 4218 1 A a DT cord-028721-x6f26ahr 4218 2 method method NN cord-028721-x6f26ahr 4218 3 for for IN cord-028721-x6f26ahr 4218 4 the the DT cord-028721-x6f26ahr 4218 5 quantifi quantifi NNP cord-028721-x6f26ahr 4218 6 cation cation NN cord-028721-x6f26ahr 4218 7 of of IN cord-028721-x6f26ahr 4218 8 Leydig Leydig NNP cord-028721-x6f26ahr 4218 9 cells cell NNS cord-028721-x6f26ahr 4218 10 in in IN cord-028721-x6f26ahr 4218 11 man man NN cord-028721-x6f26ahr 4219 1 Seminiferous seminiferous JJ cord-028721-x6f26ahr 4219 2 tubule tubule NN cord-028721-x6f26ahr 4219 3 hypercurvature hypercurvature NN cord-028721-x6f26ahr 4219 4 : : : cord-028721-x6f26ahr 4219 5 a a DT cord-028721-x6f26ahr 4219 6 newly newly RB cord-028721-x6f26ahr 4219 7 recognized recognize VBN cord-028721-x6f26ahr 4219 8 common common JJ cord-028721-x6f26ahr 4219 9 syndrome syndrome NN cord-028721-x6f26ahr 4219 10 of of IN cord-028721-x6f26ahr 4219 11 human human JJ cord-028721-x6f26ahr 4219 12 male male JJ cord-028721-x6f26ahr 4219 13 infertility infertility NN cord-028721-x6f26ahr 4219 14 Branching branch VBG cord-028721-x6f26ahr 4219 15 of of IN cord-028721-x6f26ahr 4219 16 seminiferous seminiferous JJ cord-028721-x6f26ahr 4219 17 tubules tubule NNS cord-028721-x6f26ahr 4219 18 associated associate VBN cord-028721-x6f26ahr 4219 19 with with IN cord-028721-x6f26ahr 4219 20 hypofertility hypofertility NN cord-028721-x6f26ahr 4219 21 and and CC cord-028721-x6f26ahr 4219 22 chronic chronic JJ cord-028721-x6f26ahr 4219 23 respiratory respiratory JJ cord-028721-x6f26ahr 4219 24 infection infection NN cord-028721-x6f26ahr 4219 25 Morphological morphological JJ cord-028721-x6f26ahr 4219 26 and and CC cord-028721-x6f26ahr 4219 27 histometric histometric JJ cord-028721-x6f26ahr 4219 28 study study NN cord-028721-x6f26ahr 4219 29 on on IN cord-028721-x6f26ahr 4219 30 the the DT cord-028721-x6f26ahr 4219 31 human human JJ cord-028721-x6f26ahr 4219 32 Sertoli Sertoli NNP cord-028721-x6f26ahr 4219 33 cells cell NNS cord-028721-x6f26ahr 4219 34 from from IN cord-028721-x6f26ahr 4219 35 birth birth NN cord-028721-x6f26ahr 4219 36 to to IN cord-028721-x6f26ahr 4219 37 the the DT cord-028721-x6f26ahr 4219 38 onset onset NN cord-028721-x6f26ahr 4219 39 of of IN cord-028721-x6f26ahr 4219 40 puberty puberty NN cord-028721-x6f26ahr 4219 41 Sertoli sertoli JJ cord-028721-x6f26ahr 4219 42 cell cell NN cord-028721-x6f26ahr 4219 43 types type NNS cord-028721-x6f26ahr 4219 44 in in IN cord-028721-x6f26ahr 4219 45 Sertoli Sertoli NNP cord-028721-x6f26ahr 4219 46 - - HYPH cord-028721-x6f26ahr 4219 47 cell cell NN cord-028721-x6f26ahr 4219 48 - - HYPH cord-028721-x6f26ahr 4219 49 only only JJ cord-028721-x6f26ahr 4219 50 syndrome syndrome NN cord-028721-x6f26ahr 4219 51 : : : cord-028721-x6f26ahr 4219 52 relationships relationship NNS cord-028721-x6f26ahr 4219 53 between between IN cord-028721-x6f26ahr 4219 54 Sertoli Sertoli NNP cord-028721-x6f26ahr 4219 55 cell cell NN cord-028721-x6f26ahr 4219 56 morphology morphology NN cord-028721-x6f26ahr 4219 57 and and CC cord-028721-x6f26ahr 4219 58 aetiology aetiology NN cord-028721-x6f26ahr 4219 59 Pathophysiological Pathophysiological NNP cord-028721-x6f26ahr 4219 60 observations observation NNS cord-028721-x6f26ahr 4219 61 of of IN cord-028721-x6f26ahr 4219 62 Sertoli sertoli JJ cord-028721-x6f26ahr 4219 63 cells cell NNS cord-028721-x6f26ahr 4219 64 in in IN cord-028721-x6f26ahr 4219 65 patients patient NNS cord-028721-x6f26ahr 4219 66 with with IN cord-028721-x6f26ahr 4219 67 germinal germinal JJ cord-028721-x6f26ahr 4219 68 aplasia aplasia NNP cord-028721-x6f26ahr 4219 69 or or CC cord-028721-x6f26ahr 4219 70 severe severe JJ cord-028721-x6f26ahr 4219 71 germ germ NN cord-028721-x6f26ahr 4219 72 cell cell NN cord-028721-x6f26ahr 4219 73 depletion depletion NN cord-028721-x6f26ahr 4219 74 . . . cord-028721-x6f26ahr 4220 1 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4220 2 fi fi IN cord-028721-x6f26ahr 4220 3 ndings nding NNS cord-028721-x6f26ahr 4220 4 and and CC cord-028721-x6f26ahr 4220 5 hormone hormone NN cord-028721-x6f26ahr 4220 6 levels level NNS cord-028721-x6f26ahr 4221 1 Morphological morphological JJ cord-028721-x6f26ahr 4221 2 evidence evidence NN cord-028721-x6f26ahr 4221 3 for for IN cord-028721-x6f26ahr 4221 4 two two CD cord-028721-x6f26ahr 4221 5 types type NNS cord-028721-x6f26ahr 4221 6 of of IN cord-028721-x6f26ahr 4221 7 idiopathic idiopathic JJ cord-028721-x6f26ahr 4221 8 ' ' `` cord-028721-x6f26ahr 4221 9 Sertoli sertoli JJ cord-028721-x6f26ahr 4221 10 - - HYPH cord-028721-x6f26ahr 4221 11 cell cell NN cord-028721-x6f26ahr 4221 12 - - HYPH cord-028721-x6f26ahr 4221 13 only only RB cord-028721-x6f26ahr 4221 14 ' ' '' cord-028721-x6f26ahr 4221 15 syndrome syndrome NN cord-028721-x6f26ahr 4222 1 Enzyme Enzyme NNP cord-028721-x6f26ahr 4222 2 histochemical histochemical JJ cord-028721-x6f26ahr 4222 3 studies study NNS cord-028721-x6f26ahr 4222 4 on on IN cord-028721-x6f26ahr 4222 5 the the DT cord-028721-x6f26ahr 4222 6 pathological pathological JJ cord-028721-x6f26ahr 4222 7 changes change NNS cord-028721-x6f26ahr 4222 8 in in IN cord-028721-x6f26ahr 4222 9 human human JJ cord-028721-x6f26ahr 4222 10 Sertoli Sertoli NNP cord-028721-x6f26ahr 4222 11 cells cell NNS cord-028721-x6f26ahr 4222 12 Behaviour Behaviour NNP cord-028721-x6f26ahr 4222 13 of of IN cord-028721-x6f26ahr 4222 14 glycogen glycogen NN cord-028721-x6f26ahr 4222 15 and and CC cord-028721-x6f26ahr 4222 16 related related JJ cord-028721-x6f26ahr 4222 17 enzymes enzyme NNS cord-028721-x6f26ahr 4222 18 in in IN cord-028721-x6f26ahr 4222 19 the the DT cord-028721-x6f26ahr 4222 20 Sertoli sertoli JJ cord-028721-x6f26ahr 4222 21 cell cell NN cord-028721-x6f26ahr 4222 22 syndrome syndrome NN cord-028721-x6f26ahr 4222 23 Hypoplasia Hypoplasia NNP cord-028721-x6f26ahr 4222 24 túbulo túbulo NNP cord-028721-x6f26ahr 4222 25 intersticial intersticial NNP cord-028721-x6f26ahr 4222 26 difusa difusa NNP cord-028721-x6f26ahr 4223 1 ( ( -LRB- cord-028721-x6f26ahr 4223 2 hipogonadismo hipogonadismo NNP cord-028721-x6f26ahr 4223 3 hipogonadotrópico hipogonadotrópico NNP cord-028721-x6f26ahr 4223 4 ) ) -RRB- cord-028721-x6f26ahr 4224 1 Leydig leydig NN cord-028721-x6f26ahr 4224 2 cell cell NN cord-028721-x6f26ahr 4224 3 differentiation differentiation NN cord-028721-x6f26ahr 4224 4 induced induce VBN cord-028721-x6f26ahr 4224 5 by by IN cord-028721-x6f26ahr 4224 6 stimulation stimulation NN cord-028721-x6f26ahr 4224 7 with with IN cord-028721-x6f26ahr 4224 8 HCG HCG NNP cord-028721-x6f26ahr 4224 9 and and CC cord-028721-x6f26ahr 4224 10 HMG HMG NNP cord-028721-x6f26ahr 4224 11 in in IN cord-028721-x6f26ahr 4224 12 two two CD cord-028721-x6f26ahr 4224 13 patients patient NNS cord-028721-x6f26ahr 4224 14 affected affect VBN cord-028721-x6f26ahr 4224 15 with with IN cord-028721-x6f26ahr 4224 16 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4224 17 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 4225 1 The the DT cord-028721-x6f26ahr 4225 2 fi fi NNP cord-028721-x6f26ahr 4225 3 ne ne NNP cord-028721-x6f26ahr 4225 4 structure structure NN cord-028721-x6f26ahr 4225 5 of of IN cord-028721-x6f26ahr 4225 6 the the DT cord-028721-x6f26ahr 4225 7 immature immature JJ cord-028721-x6f26ahr 4225 8 human human JJ cord-028721-x6f26ahr 4225 9 testis testis NN cord-028721-x6f26ahr 4225 10 in in IN cord-028721-x6f26ahr 4225 11 hypogonadotrophic hypogonadotrophic NNP cord-028721-x6f26ahr 4225 12 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4225 13 Hyperplasia Hyperplasia NNP cord-028721-x6f26ahr 4225 14 and and CC cord-028721-x6f26ahr 4225 15 the the DT cord-028721-x6f26ahr 4225 16 immature immature JJ cord-028721-x6f26ahr 4225 17 appearance appearance NN cord-028721-x6f26ahr 4225 18 of of IN cord-028721-x6f26ahr 4225 19 Sertoli Sertoli NNP cord-028721-x6f26ahr 4225 20 cells cell NNS cord-028721-x6f26ahr 4225 21 in in IN cord-028721-x6f26ahr 4225 22 primary primary JJ cord-028721-x6f26ahr 4225 23 testicular testicular JJ cord-028721-x6f26ahr 4225 24 disorders disorder NNS cord-028721-x6f26ahr 4226 1 Immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4226 2 detection detection NN cord-028721-x6f26ahr 4226 3 of of IN cord-028721-x6f26ahr 4226 4 immature immature JJ cord-028721-x6f26ahr 4226 5 Sertoli sertoli JJ cord-028721-x6f26ahr 4226 6 cell cell NN cord-028721-x6f26ahr 4226 7 markers marker NNS cord-028721-x6f26ahr 4226 8 in in IN cord-028721-x6f26ahr 4226 9 testicular testicular JJ cord-028721-x6f26ahr 4226 10 tissue tissue NN cord-028721-x6f26ahr 4226 11 of of IN cord-028721-x6f26ahr 4226 12 infertile infertile JJ cord-028721-x6f26ahr 4226 13 adult adult NN cord-028721-x6f26ahr 4226 14 men man NNS cord-028721-x6f26ahr 4226 15 : : : cord-028721-x6f26ahr 4226 16 a a DT cord-028721-x6f26ahr 4226 17 preliminary preliminary JJ cord-028721-x6f26ahr 4226 18 study study NN cord-028721-x6f26ahr 4226 19 Maturation maturation NN cord-028721-x6f26ahr 4226 20 phenotype phenotype NN cord-028721-x6f26ahr 4226 21 of of IN cord-028721-x6f26ahr 4226 22 Sertoli Sertoli NNP cord-028721-x6f26ahr 4226 23 cells cell NNS cord-028721-x6f26ahr 4226 24 in in IN cord-028721-x6f26ahr 4226 25 testicular testicular JJ cord-028721-x6f26ahr 4226 26 biopsies biopsy NNS cord-028721-x6f26ahr 4226 27 of of IN cord-028721-x6f26ahr 4226 28 azoospermic azoospermic NNP cord-028721-x6f26ahr 4226 29 men man NNS cord-028721-x6f26ahr 4227 1 The the DT cord-028721-x6f26ahr 4227 2 human human JJ cord-028721-x6f26ahr 4227 3 blood blood NN cord-028721-x6f26ahr 4227 4 - - HYPH cord-028721-x6f26ahr 4227 5 testis testis NN cord-028721-x6f26ahr 4227 6 barrier barrier NN cord-028721-x6f26ahr 4227 7 in in IN cord-028721-x6f26ahr 4227 8 impaired impaired JJ cord-028721-x6f26ahr 4227 9 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4227 10 Reversion Reversion NNP cord-028721-x6f26ahr 4227 11 of of IN cord-028721-x6f26ahr 4227 12 the the DT cord-028721-x6f26ahr 4227 13 differentiated differentiated JJ cord-028721-x6f26ahr 4227 14 phenotype phenotype NN cord-028721-x6f26ahr 4227 15 and and CC cord-028721-x6f26ahr 4227 16 maturation maturation NN cord-028721-x6f26ahr 4227 17 block block NN cord-028721-x6f26ahr 4227 18 in in IN cord-028721-x6f26ahr 4227 19 Sertoli Sertoli NNP cord-028721-x6f26ahr 4227 20 cells cell NNS cord-028721-x6f26ahr 4227 21 in in IN cord-028721-x6f26ahr 4227 22 pathological pathological JJ cord-028721-x6f26ahr 4227 23 human human JJ cord-028721-x6f26ahr 4227 24 testis testis NN cord-028721-x6f26ahr 4227 25 Leydig Leydig NNP cord-028721-x6f26ahr 4227 26 cell cell NN cord-028721-x6f26ahr 4227 27 types type NNS cord-028721-x6f26ahr 4227 28 in in IN cord-028721-x6f26ahr 4227 29 primary primary JJ cord-028721-x6f26ahr 4227 30 testicular testicular JJ cord-028721-x6f26ahr 4227 31 disorders disorder NNS cord-028721-x6f26ahr 4228 1 Ectopic ectopic JJ cord-028721-x6f26ahr 4228 2 testis testis NN cord-028721-x6f26ahr 4228 3 and and CC cord-028721-x6f26ahr 4228 4 the the DT cord-028721-x6f26ahr 4228 5 undescended undescended JJ cord-028721-x6f26ahr 4228 6 testis testis NN cord-028721-x6f26ahr 4228 7 : : : cord-028721-x6f26ahr 4228 8 a a DT cord-028721-x6f26ahr 4228 9 histological histological JJ cord-028721-x6f26ahr 4228 10 comparison comparison NN cord-028721-x6f26ahr 4228 11 Short short JJ cord-028721-x6f26ahr 4228 12 arm arm NN cord-028721-x6f26ahr 4228 13 dicentric dicentric NNP cord-028721-x6f26ahr 4228 14 Y Y NNP cord-028721-x6f26ahr 4228 15 chromosome chromosome NN cord-028721-x6f26ahr 4228 16 in in IN cord-028721-x6f26ahr 4228 17 a a DT cord-028721-x6f26ahr 4228 18 sterile sterile JJ cord-028721-x6f26ahr 4228 19 man man NN cord-028721-x6f26ahr 4228 20 : : : cord-028721-x6f26ahr 4228 21 a a DT cord-028721-x6f26ahr 4228 22 case case NN cord-028721-x6f26ahr 4228 23 report report NN cord-028721-x6f26ahr 4228 24 Intermediate Intermediate NNP cord-028721-x6f26ahr 4228 25 fi fi NNP cord-028721-x6f26ahr 4228 26 laments lament NNS cord-028721-x6f26ahr 4228 27 in in IN cord-028721-x6f26ahr 4228 28 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 29 cells cell NNS cord-028721-x6f26ahr 4228 30 Urinary urinary JJ cord-028721-x6f26ahr 4228 31 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 4228 32 in in IN cord-028721-x6f26ahr 4228 33 the the DT cord-028721-x6f26ahr 4228 34 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 35 - - HYPH cord-028721-x6f26ahr 4228 36 cell cell NN cord-028721-x6f26ahr 4228 37 - - HYPH cord-028721-x6f26ahr 4228 38 only only JJ cord-028721-x6f26ahr 4228 39 syndrome syndrome NN cord-028721-x6f26ahr 4228 40 Impaired impair VBD cord-028721-x6f26ahr 4228 41 Leydig Leydig NNP cord-028721-x6f26ahr 4228 42 cell cell NN cord-028721-x6f26ahr 4228 43 function function NN cord-028721-x6f26ahr 4228 44 in in IN cord-028721-x6f26ahr 4228 45 vitro vitro FW cord-028721-x6f26ahr 4228 46 in in IN cord-028721-x6f26ahr 4228 47 testicular testicular JJ cord-028721-x6f26ahr 4228 48 tissue tissue NN cord-028721-x6f26ahr 4228 49 from from IN cord-028721-x6f26ahr 4228 50 human human JJ cord-028721-x6f26ahr 4228 51 males male NNS cord-028721-x6f26ahr 4228 52 with with IN cord-028721-x6f26ahr 4228 53 ' ' `` cord-028721-x6f26ahr 4228 54 Sertoli sertoli JJ cord-028721-x6f26ahr 4228 55 cell cell NN cord-028721-x6f26ahr 4228 56 only only RB cord-028721-x6f26ahr 4228 57 ' ' '' cord-028721-x6f26ahr 4228 58 syndrome syndrome NN cord-028721-x6f26ahr 4228 59 Testicular Testicular NNP cord-028721-x6f26ahr 4228 60 FSH FSH NNP cord-028721-x6f26ahr 4228 61 and and CC cord-028721-x6f26ahr 4228 62 HCG hcg NN cord-028721-x6f26ahr 4228 63 receptors receptor NNS cord-028721-x6f26ahr 4228 64 in in IN cord-028721-x6f26ahr 4228 65 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 66 - - HYPH cord-028721-x6f26ahr 4228 67 cell cell NN cord-028721-x6f26ahr 4228 68 - - HYPH cord-028721-x6f26ahr 4228 69 only only JJ cord-028721-x6f26ahr 4228 70 syndrome syndrome NN cord-028721-x6f26ahr 4228 71 Syndrome syndrome NN cord-028721-x6f26ahr 4228 72 produced produce VBN cord-028721-x6f26ahr 4228 73 by by IN cord-028721-x6f26ahr 4228 74 absence absence NN cord-028721-x6f26ahr 4228 75 of of IN cord-028721-x6f26ahr 4228 76 the the DT cord-028721-x6f26ahr 4228 77 germinal germinal JJ cord-028721-x6f26ahr 4228 78 epithelium epithelium NN cord-028721-x6f26ahr 4228 79 without without IN cord-028721-x6f26ahr 4228 80 impairment impairment NN cord-028721-x6f26ahr 4228 81 of of IN cord-028721-x6f26ahr 4228 82 the the DT cord-028721-x6f26ahr 4228 83 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 84 or or CC cord-028721-x6f26ahr 4228 85 Leydig leydig NN cord-028721-x6f26ahr 4228 86 cells cell NNS cord-028721-x6f26ahr 4228 87 AZFa AZFa NNS cord-028721-x6f26ahr 4228 88 deletions deletion NNS cord-028721-x6f26ahr 4228 89 in in IN cord-028721-x6f26ahr 4228 90 Sertoli sertoli JJ cord-028721-x6f26ahr 4228 91 cell cell NN cord-028721-x6f26ahr 4228 92 - - HYPH cord-028721-x6f26ahr 4228 93 only only JJ cord-028721-x6f26ahr 4228 94 syndrome syndrome NN cord-028721-x6f26ahr 4228 95 : : : cord-028721-x6f26ahr 4228 96 a a DT cord-028721-x6f26ahr 4228 97 retrospective retrospective JJ cord-028721-x6f26ahr 4228 98 study study NN cord-028721-x6f26ahr 4228 99 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 100 cell cell NN cord-028721-x6f26ahr 4228 101 only only RB cord-028721-x6f26ahr 4228 102 syndrome syndrome NN cord-028721-x6f26ahr 4228 103 in in IN cord-028721-x6f26ahr 4228 104 1982 1982 CD cord-028721-x6f26ahr 4228 105 Return Return NNP cord-028721-x6f26ahr 4228 106 of of IN cord-028721-x6f26ahr 4228 107 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4228 108 after after IN cord-028721-x6f26ahr 4228 109 stopping stop VBG cord-028721-x6f26ahr 4228 110 cyclophosphamide cyclophosphamide NN cord-028721-x6f26ahr 4228 111 therapy therapy NN cord-028721-x6f26ahr 4228 112 Evidence evidence NN cord-028721-x6f26ahr 4228 113 for for IN cord-028721-x6f26ahr 4228 114 testicular testicular JJ cord-028721-x6f26ahr 4228 115 impairment impairment NN cord-028721-x6f26ahr 4228 116 after after IN cord-028721-x6f26ahr 4228 117 long long JJ cord-028721-x6f26ahr 4228 118 - - HYPH cord-028721-x6f26ahr 4228 119 term term NN cord-028721-x6f26ahr 4228 120 treatment treatment NN cord-028721-x6f26ahr 4228 121 with with IN cord-028721-x6f26ahr 4228 122 a a DT cord-028721-x6f26ahr 4228 123 luteinizing luteinize VBG cord-028721-x6f26ahr 4228 124 hormone hormone NN cord-028721-x6f26ahr 4228 125 - - HYPH cord-028721-x6f26ahr 4228 126 releasing release VBG cord-028721-x6f26ahr 4228 127 hormone hormone NN cord-028721-x6f26ahr 4228 128 agonist agonist NN cord-028721-x6f26ahr 4228 129 in in IN cord-028721-x6f26ahr 4228 130 elderly elderly JJ cord-028721-x6f26ahr 4228 131 men man NNS cord-028721-x6f26ahr 4228 132 Effects effect NNS cord-028721-x6f26ahr 4228 133 of of IN cord-028721-x6f26ahr 4228 134 estrogens estrogen NNS cord-028721-x6f26ahr 4228 135 on on IN cord-028721-x6f26ahr 4228 136 the the DT cord-028721-x6f26ahr 4228 137 testis testis NN cord-028721-x6f26ahr 4228 138 of of IN cord-028721-x6f26ahr 4228 139 transsexuals transsexual NNS cord-028721-x6f26ahr 4228 140 : : : cord-028721-x6f26ahr 4228 141 a a DT cord-028721-x6f26ahr 4228 142 pathological pathological JJ cord-028721-x6f26ahr 4228 143 and and CC cord-028721-x6f26ahr 4228 144 immunocytochemical immunocytochemical JJ cord-028721-x6f26ahr 4228 145 study study NN cord-028721-x6f26ahr 4228 146 Response response NN cord-028721-x6f26ahr 4228 147 of of IN cord-028721-x6f26ahr 4228 148 the the DT cord-028721-x6f26ahr 4228 149 human human JJ cord-028721-x6f26ahr 4228 150 testis testis NN cord-028721-x6f26ahr 4228 151 to to IN cord-028721-x6f26ahr 4228 152 long long JJ cord-028721-x6f26ahr 4228 153 - - HYPH cord-028721-x6f26ahr 4228 154 term term NN cord-028721-x6f26ahr 4228 155 estrogen estrogen NN cord-028721-x6f26ahr 4228 156 treatment treatment NN cord-028721-x6f26ahr 4228 157 : : : cord-028721-x6f26ahr 4228 158 Morphology morphology NN cord-028721-x6f26ahr 4228 159 of of IN cord-028721-x6f26ahr 4228 160 Sertoli Sertoli NNP cord-028721-x6f26ahr 4228 161 cells cell NNS cord-028721-x6f26ahr 4228 162 , , , cord-028721-x6f26ahr 4228 163 Leydig leydig NN cord-028721-x6f26ahr 4228 164 cells cell NNS cord-028721-x6f26ahr 4228 165 and and CC cord-028721-x6f26ahr 4228 166 spermatogonial spermatogonial JJ cord-028721-x6f26ahr 4228 167 stem stem NN cord-028721-x6f26ahr 4228 168 cells cell NNS cord-028721-x6f26ahr 4229 1 Depressed depressed JJ cord-028721-x6f26ahr 4229 2 testosterone testosterone NN cord-028721-x6f26ahr 4229 3 release release NN cord-028721-x6f26ahr 4229 4 from from IN cord-028721-x6f26ahr 4229 5 testicular testicular JJ cord-028721-x6f26ahr 4229 6 tissue tissue NN cord-028721-x6f26ahr 4229 7 in in IN cord-028721-x6f26ahr 4229 8 vitro vitro FW cord-028721-x6f26ahr 4229 9 after after IN cord-028721-x6f26ahr 4229 10 withdrawal withdrawal NN cord-028721-x6f26ahr 4229 11 of of IN cord-028721-x6f26ahr 4229 12 oestrogen oestrogen NN cord-028721-x6f26ahr 4229 13 treatment treatment NN cord-028721-x6f26ahr 4229 14 in in IN cord-028721-x6f26ahr 4229 15 patients patient NNS cord-028721-x6f26ahr 4229 16 with with IN cord-028721-x6f26ahr 4229 17 prostatic prostatic JJ cord-028721-x6f26ahr 4229 18 carcinoma carcinoma NN cord-028721-x6f26ahr 4229 19 Tubular tubular JJ cord-028721-x6f26ahr 4229 20 hyalinization hyalinization NN cord-028721-x6f26ahr 4229 21 in in IN cord-028721-x6f26ahr 4229 22 human human JJ cord-028721-x6f26ahr 4229 23 testes testis NNS cord-028721-x6f26ahr 4230 1 The the DT cord-028721-x6f26ahr 4230 2 peritubular peritubular JJ cord-028721-x6f26ahr 4230 3 myofi myofi NNP cord-028721-x6f26ahr 4230 4 broblasts broblasts NNP cord-028721-x6f26ahr 4230 5 in in IN cord-028721-x6f26ahr 4230 6 the the DT cord-028721-x6f26ahr 4230 7 testes testis NNS cord-028721-x6f26ahr 4230 8 from from IN cord-028721-x6f26ahr 4230 9 normal normal JJ cord-028721-x6f26ahr 4230 10 men man NNS cord-028721-x6f26ahr 4230 11 and and CC cord-028721-x6f26ahr 4230 12 men man NNS cord-028721-x6f26ahr 4230 13 with with IN cord-028721-x6f26ahr 4230 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4230 15 's 's POS cord-028721-x6f26ahr 4230 16 syndrome syndrome NN cord-028721-x6f26ahr 4230 17 . . . cord-028721-x6f26ahr 4231 1 A a DT cord-028721-x6f26ahr 4231 2 quantitative quantitative JJ cord-028721-x6f26ahr 4231 3 , , , cord-028721-x6f26ahr 4231 4 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4231 5 , , , cord-028721-x6f26ahr 4231 6 and and CC cord-028721-x6f26ahr 4231 7 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4231 8 study study NN cord-028721-x6f26ahr 4231 9 Laminin Laminin NNP cord-028721-x6f26ahr 4231 10 , , , cord-028721-x6f26ahr 4231 11 type type NN cord-028721-x6f26ahr 4231 12 IV IV NNP cord-028721-x6f26ahr 4231 13 collagen collagen NN cord-028721-x6f26ahr 4231 14 , , , cord-028721-x6f26ahr 4231 15 and and CC cord-028721-x6f26ahr 4231 16 fi fi NNP cord-028721-x6f26ahr 4231 17 bronectin bronectin NNP cord-028721-x6f26ahr 4231 18 in in IN cord-028721-x6f26ahr 4231 19 normal normal JJ cord-028721-x6f26ahr 4231 20 References reference NNS cord-028721-x6f26ahr 4231 21 and and CC cord-028721-x6f26ahr 4231 22 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4231 23 human human JJ cord-028721-x6f26ahr 4231 24 testes testis NNS cord-028721-x6f26ahr 4231 25 . . . cord-028721-x6f26ahr 4232 1 An an DT cord-028721-x6f26ahr 4232 2 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4232 3 study study NN cord-028721-x6f26ahr 4232 4 Testicular testicular JJ cord-028721-x6f26ahr 4232 5 atrophy atrophy NN cord-028721-x6f26ahr 4232 6 as as IN cord-028721-x6f26ahr 4232 7 a a DT cord-028721-x6f26ahr 4232 8 sequela sequela NN cord-028721-x6f26ahr 4232 9 of of IN cord-028721-x6f26ahr 4232 10 inguinal inguinal JJ cord-028721-x6f26ahr 4232 11 herniorrhaphy herniorrhaphy NN cord-028721-x6f26ahr 4232 12 Testis Testis NNP cord-028721-x6f26ahr 4232 13 epididymis epididymis NN cord-028721-x6f26ahr 4232 14 , , , cord-028721-x6f26ahr 4232 15 and and CC cord-028721-x6f26ahr 4232 16 spermatic spermatic JJ cord-028721-x6f26ahr 4232 17 cord cord NN cord-028721-x6f26ahr 4232 18 in in IN cord-028721-x6f26ahr 4232 19 elderly elderly JJ cord-028721-x6f26ahr 4232 20 men man NNS cord-028721-x6f26ahr 4232 21 . . . cord-028721-x6f26ahr 4233 1 Correlation correlation NN cord-028721-x6f26ahr 4233 2 of of IN cord-028721-x6f26ahr 4233 3 angiographic angiographic JJ cord-028721-x6f26ahr 4233 4 and and CC cord-028721-x6f26ahr 4233 5 histologic histologic JJ cord-028721-x6f26ahr 4233 6 studies study NNS cord-028721-x6f26ahr 4233 7 with with IN cord-028721-x6f26ahr 4233 8 systemic systemic JJ cord-028721-x6f26ahr 4233 9 arteriosclerosis arteriosclerosis NN cord-028721-x6f26ahr 4233 10 Primary primary JJ cord-028721-x6f26ahr 4233 11 testicular testicular JJ cord-028721-x6f26ahr 4233 12 lesions lesion NNS cord-028721-x6f26ahr 4233 13 in in IN cord-028721-x6f26ahr 4233 14 the the DT cord-028721-x6f26ahr 4233 15 twisted twisted JJ cord-028721-x6f26ahr 4233 16 testis testis NN cord-028721-x6f26ahr 4233 17 Infl Infl NNP cord-028721-x6f26ahr 4233 18 ammation ammation NN cord-028721-x6f26ahr 4233 19 and and CC cord-028721-x6f26ahr 4233 20 infestation infestation NN cord-028721-x6f26ahr 4233 21 of of IN cord-028721-x6f26ahr 4233 22 the the DT cord-028721-x6f26ahr 4233 23 testis testis NN cord-028721-x6f26ahr 4233 24 and and CC cord-028721-x6f26ahr 4233 25 paratesticular paratesticular JJ cord-028721-x6f26ahr 4233 26 structures structure NNS cord-028721-x6f26ahr 4234 1 Quantitative quantitative JJ cord-028721-x6f26ahr 4234 2 testicular testicular JJ cord-028721-x6f26ahr 4234 3 biopsy biopsy NN cord-028721-x6f26ahr 4234 4 in in IN cord-028721-x6f26ahr 4234 5 congenital congenital JJ cord-028721-x6f26ahr 4234 6 and and CC cord-028721-x6f26ahr 4234 7 acquired acquire VBD cord-028721-x6f26ahr 4234 8 genital genital JJ cord-028721-x6f26ahr 4234 9 obstruction obstruction NN cord-028721-x6f26ahr 4235 1 The the DT cord-028721-x6f26ahr 4235 2 peritubular peritubular JJ cord-028721-x6f26ahr 4235 3 myoid myoid NN cord-028721-x6f26ahr 4235 4 cells cell NNS cord-028721-x6f26ahr 4235 5 in in IN cord-028721-x6f26ahr 4235 6 the the DT cord-028721-x6f26ahr 4235 7 testes testis NNS cord-028721-x6f26ahr 4235 8 from from IN cord-028721-x6f26ahr 4235 9 men man NNS cord-028721-x6f26ahr 4235 10 with with IN cord-028721-x6f26ahr 4235 11 varicocele varicocele NN cord-028721-x6f26ahr 4235 12 . . . cord-028721-x6f26ahr 4236 1 An an DT cord-028721-x6f26ahr 4236 2 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4236 3 , , , cord-028721-x6f26ahr 4236 4 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4236 5 and and CC cord-028721-x6f26ahr 4236 6 quantitative quantitative JJ cord-028721-x6f26ahr 4236 7 study study NN cord-028721-x6f26ahr 4236 8 Striated Striated NNP cord-028721-x6f26ahr 4236 9 pattern pattern NN cord-028721-x6f26ahr 4236 10 of of IN cord-028721-x6f26ahr 4236 11 the the DT cord-028721-x6f26ahr 4236 12 testicle testicle NN cord-028721-x6f26ahr 4236 13 on on IN cord-028721-x6f26ahr 4236 14 ultrasound ultrasound NN cord-028721-x6f26ahr 4236 15 : : : cord-028721-x6f26ahr 4236 16 an an DT cord-028721-x6f26ahr 4236 17 appearance appearance NN cord-028721-x6f26ahr 4236 18 of of IN cord-028721-x6f26ahr 4236 19 testicular testicular NN cord-028721-x6f26ahr 4236 20 fi fi NN cord-028721-x6f26ahr 4236 21 brosis brosis NN cord-028721-x6f26ahr 4236 22 Clinical clinical JJ cord-028721-x6f26ahr 4236 23 importance importance NN cord-028721-x6f26ahr 4236 24 of of IN cord-028721-x6f26ahr 4236 25 a a DT cord-028721-x6f26ahr 4236 26 unilateral unilateral JJ cord-028721-x6f26ahr 4236 27 striated striated JJ cord-028721-x6f26ahr 4236 28 pattern pattern NN cord-028721-x6f26ahr 4236 29 seen see VBN cord-028721-x6f26ahr 4236 30 on on IN cord-028721-x6f26ahr 4236 31 sonography sonography NN cord-028721-x6f26ahr 4236 32 of of IN cord-028721-x6f26ahr 4236 33 the the DT cord-028721-x6f26ahr 4236 34 testicle testicle NN cord-028721-x6f26ahr 4236 35 Suppressive suppressive JJ cord-028721-x6f26ahr 4236 36 effects effect NNS cord-028721-x6f26ahr 4236 37 of of IN cord-028721-x6f26ahr 4236 38 1,2-dibromo-3 1,2-dibromo-3 CD cord-028721-x6f26ahr 4236 39 - - SYM cord-028721-x6f26ahr 4236 40 3-chloropropane 3-chloropropane CD cord-028721-x6f26ahr 4236 41 on on IN cord-028721-x6f26ahr 4236 42 human human JJ cord-028721-x6f26ahr 4236 43 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4236 44 Signifi Signifi NNP cord-028721-x6f26ahr 4236 45 cance cance NN cord-028721-x6f26ahr 4236 46 of of IN cord-028721-x6f26ahr 4236 47 testicular testicular JJ cord-028721-x6f26ahr 4236 48 exfoliation exfoliation NN cord-028721-x6f26ahr 4236 49 in in IN cord-028721-x6f26ahr 4236 50 male male JJ cord-028721-x6f26ahr 4236 51 infecundity infecundity NNP cord-028721-x6f26ahr 4236 52 Laboratory Laboratory NNP cord-028721-x6f26ahr 4236 53 manual manual NN cord-028721-x6f26ahr 4236 54 for for IN cord-028721-x6f26ahr 4236 55 the the DT cord-028721-x6f26ahr 4236 56 examination examination NN cord-028721-x6f26ahr 4236 57 of of IN cord-028721-x6f26ahr 4236 58 human human JJ cord-028721-x6f26ahr 4236 59 semen semen NN cord-028721-x6f26ahr 4236 60 and and CC cord-028721-x6f26ahr 4236 61 semen semen NN cord-028721-x6f26ahr 4236 62 - - HYPH cord-028721-x6f26ahr 4236 63 cervical cervical JJ cord-028721-x6f26ahr 4236 64 mucus mucus NN cord-028721-x6f26ahr 4236 65 interaction interaction NN cord-028721-x6f26ahr 4236 66 Zytologische Zytologische NNP cord-028721-x6f26ahr 4236 67 Klassifi Klassifi NNP cord-028721-x6f26ahr 4236 68 kation kation NN cord-028721-x6f26ahr 4236 69 in in IN cord-028721-x6f26ahr 4236 70 reifer reifer NNP cord-028721-x6f26ahr 4237 1 Keimzellen Keimzellen NNP cord-028721-x6f26ahr 4238 1 i i PRP cord-028721-x6f26ahr 4239 1 m m NNP cord-028721-x6f26ahr 4239 2 Luftgetrockneten Luftgetrockneten NNP cord-028721-x6f26ahr 4239 3 Ejakulatanstrich Ejakulatanstrich NNP cord-028721-x6f26ahr 4239 4 beim beim NNP cord-028721-x6f26ahr 4239 5 spermatologische spermatologische NN cord-028721-x6f26ahr 4239 6 Syndrom Syndrom NNP cord-028721-x6f26ahr 4239 7 der der NNP cord-028721-x6f26ahr 4239 8 vermehrten vermehrten NNP cord-028721-x6f26ahr 4239 9 Desquamation Desquamation NNP cord-028721-x6f26ahr 4239 10 von von NNP cord-028721-x6f26ahr 4239 11 Zellen Zellen NNP cord-028721-x6f26ahr 4239 12 der der NNP cord-028721-x6f26ahr 4239 13 Spermatogenese Spermatogenese NNP cord-028721-x6f26ahr 4239 14 ( ( -LRB- cord-028721-x6f26ahr 4239 15 VDZS VDZS NNP cord-028721-x6f26ahr 4239 16 ) ) -RRB- cord-028721-x6f26ahr 4240 1 Transformed transform VBN cord-028721-x6f26ahr 4240 2 spermatocytes spermatocytes NNPS cord-028721-x6f26ahr 4240 3 constituting constitute VBG cord-028721-x6f26ahr 4240 4 the the DT cord-028721-x6f26ahr 4240 5 ejaculate ejaculate NN cord-028721-x6f26ahr 4240 6 of of IN cord-028721-x6f26ahr 4240 7 an an DT cord-028721-x6f26ahr 4240 8 infertile infertile JJ cord-028721-x6f26ahr 4240 9 man man NN cord-028721-x6f26ahr 4240 10 Studies study NNS cord-028721-x6f26ahr 4240 11 on on IN cord-028721-x6f26ahr 4240 12 the the DT cord-028721-x6f26ahr 4240 13 differentiation differentiation NN cord-028721-x6f26ahr 4240 14 of of IN cord-028721-x6f26ahr 4240 15 round round JJ cord-028721-x6f26ahr 4240 16 cells cell NNS cord-028721-x6f26ahr 4240 17 in in IN cord-028721-x6f26ahr 4240 18 the the DT cord-028721-x6f26ahr 4240 19 human human JJ cord-028721-x6f26ahr 4240 20 ejaculate ejaculate NN cord-028721-x6f26ahr 4240 21 Diagnostic diagnostic JJ cord-028721-x6f26ahr 4240 22 value value NN cord-028721-x6f26ahr 4240 23 of of IN cord-028721-x6f26ahr 4240 24 differential differential JJ cord-028721-x6f26ahr 4240 25 quantifi quantifi NNP cord-028721-x6f26ahr 4240 26 cation cation NNP cord-028721-x6f26ahr 4240 27 of of IN cord-028721-x6f26ahr 4240 28 spermatids spermatids NNP cord-028721-x6f26ahr 4240 29 in in IN cord-028721-x6f26ahr 4240 30 obstructive obstructive JJ cord-028721-x6f26ahr 4240 31 azoospermia azoospermia NN cord-028721-x6f26ahr 4240 32 Seminal seminal JJ cord-028721-x6f26ahr 4240 33 cytology cytology NN cord-028721-x6f26ahr 4240 34 in in IN cord-028721-x6f26ahr 4240 35 the the DT cord-028721-x6f26ahr 4240 36 presence presence NN cord-028721-x6f26ahr 4240 37 of of IN cord-028721-x6f26ahr 4240 38 varicocele varicocele NNP cord-028721-x6f26ahr 4241 1 The the DT cord-028721-x6f26ahr 4241 2 pathophysiology pathophysiology NN cord-028721-x6f26ahr 4241 3 of of IN cord-028721-x6f26ahr 4241 4 varicocele varicocele NN cord-028721-x6f26ahr 4241 5 in in IN cord-028721-x6f26ahr 4241 6 male male JJ cord-028721-x6f26ahr 4241 7 infertility infertility NN cord-028721-x6f26ahr 4241 8 Obstruction obstruction NN cord-028721-x6f26ahr 4241 9 of of IN cord-028721-x6f26ahr 4241 10 the the DT cord-028721-x6f26ahr 4241 11 tubuli tubuli NNP cord-028721-x6f26ahr 4241 12 recti recti NNP cord-028721-x6f26ahr 4241 13 and and CC cord-028721-x6f26ahr 4241 14 ductuli ductuli NNP cord-028721-x6f26ahr 4241 15 efferentes efferentes NNP cord-028721-x6f26ahr 4241 16 by by IN cord-028721-x6f26ahr 4241 17 dilated dilated JJ cord-028721-x6f26ahr 4241 18 veins vein NNS cord-028721-x6f26ahr 4241 19 in in IN cord-028721-x6f26ahr 4241 20 the the DT cord-028721-x6f26ahr 4241 21 testes testis NNS cord-028721-x6f26ahr 4241 22 of of IN cord-028721-x6f26ahr 4241 23 men man NNS cord-028721-x6f26ahr 4241 24 with with IN cord-028721-x6f26ahr 4241 25 varicocele varicocele NN cord-028721-x6f26ahr 4241 26 and and CC cord-028721-x6f26ahr 4241 27 its -PRON- PRP$ cord-028721-x6f26ahr 4241 28 possible possible JJ cord-028721-x6f26ahr 4241 29 role role NN cord-028721-x6f26ahr 4241 30 in in IN cord-028721-x6f26ahr 4241 31 causing cause VBG cord-028721-x6f26ahr 4241 32 atrophy atrophy NN cord-028721-x6f26ahr 4241 33 of of IN cord-028721-x6f26ahr 4241 34 the the DT cord-028721-x6f26ahr 4241 35 seminiferous seminiferous JJ cord-028721-x6f26ahr 4241 36 tubules tubule NNS cord-028721-x6f26ahr 4241 37 Scanning Scanning NNP cord-028721-x6f26ahr 4241 38 electron electron NN cord-028721-x6f26ahr 4241 39 microscopic microscopic JJ cord-028721-x6f26ahr 4241 40 study study NN cord-028721-x6f26ahr 4241 41 on on IN cord-028721-x6f26ahr 4241 42 the the DT cord-028721-x6f26ahr 4241 43 shape shape NN cord-028721-x6f26ahr 4241 44 of of IN cord-028721-x6f26ahr 4241 45 infertile infertile JJ cord-028721-x6f26ahr 4241 46 seminiferous seminiferous JJ cord-028721-x6f26ahr 4241 47 tubules tubule NNS cord-028721-x6f26ahr 4241 48 : : : cord-028721-x6f26ahr 4242 1 A a DT cord-028721-x6f26ahr 4242 2 hypothesis hypothesis NN cord-028721-x6f26ahr 4242 3 of of IN cord-028721-x6f26ahr 4242 4 pathogenesis pathogenesis NN cord-028721-x6f26ahr 4242 5 of of IN cord-028721-x6f26ahr 4242 6 idiopathic idiopathic JJ cord-028721-x6f26ahr 4242 7 male male JJ cord-028721-x6f26ahr 4242 8 infertility infertility NN cord-028721-x6f26ahr 4243 1 The the DT cord-028721-x6f26ahr 4243 2 histopathology histopathology NN cord-028721-x6f26ahr 4243 3 of of IN cord-028721-x6f26ahr 4243 4 acute acute JJ cord-028721-x6f26ahr 4243 5 mumps mumps NN cord-028721-x6f26ahr 4243 6 orchitis orchitis NN cord-028721-x6f26ahr 4243 7 An an DT cord-028721-x6f26ahr 4243 8 azoospermic azoospermic JJ cord-028721-x6f26ahr 4243 9 man man NN cord-028721-x6f26ahr 4243 10 with with IN cord-028721-x6f26ahr 4243 11 a a DT cord-028721-x6f26ahr 4243 12 double double JJ cord-028721-x6f26ahr 4243 13 - - HYPH cord-028721-x6f26ahr 4243 14 strand strand NN cord-028721-x6f26ahr 4243 15 DNA dna NN cord-028721-x6f26ahr 4243 16 break break NN cord-028721-x6f26ahr 4243 17 - - HYPH cord-028721-x6f26ahr 4243 18 processing processing NN cord-028721-x6f26ahr 4243 19 defi defi NNP cord-028721-x6f26ahr 4243 20 ciency ciency NNP cord-028721-x6f26ahr 4243 21 in in IN cord-028721-x6f26ahr 4243 22 the the DT cord-028721-x6f26ahr 4243 23 spermatocyte spermatocyte NNP cord-028721-x6f26ahr 4243 24 nuclei nucleus NNS cord-028721-x6f26ahr 4243 25 : : : cord-028721-x6f26ahr 4243 26 case case NNP cord-028721-x6f26ahr 4243 27 report report NNP cord-028721-x6f26ahr 4243 28 Association Association NNP cord-028721-x6f26ahr 4243 29 of of IN cord-028721-x6f26ahr 4243 30 three three CD cord-028721-x6f26ahr 4243 31 isoforms isoform NNS cord-028721-x6f26ahr 4243 32 of of IN cord-028721-x6f26ahr 4243 33 the the DT cord-028721-x6f26ahr 4243 34 meiotic meiotic JJ cord-028721-x6f26ahr 4243 35 BOULE BOULE NNP cord-028721-x6f26ahr 4243 36 gene gene NN cord-028721-x6f26ahr 4243 37 with with IN cord-028721-x6f26ahr 4243 38 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 4243 39 failure failure NN cord-028721-x6f26ahr 4243 40 in in IN cord-028721-x6f26ahr 4243 41 infertile infertile JJ cord-028721-x6f26ahr 4243 42 men man NNS cord-028721-x6f26ahr 4243 43 Abnormal abnormal JJ cord-028721-x6f26ahr 4243 44 germ germ NN cord-028721-x6f26ahr 4243 45 cell cell NN cord-028721-x6f26ahr 4243 46 exfoliation exfoliation NN cord-028721-x6f26ahr 4243 47 in in IN cord-028721-x6f26ahr 4243 48 semen semen NN cord-028721-x6f26ahr 4243 49 of of IN cord-028721-x6f26ahr 4243 50 hypogonadotrophic hypogonadotrophic JJ cord-028721-x6f26ahr 4243 51 patients patient NNS cord-028721-x6f26ahr 4243 52 during during IN cord-028721-x6f26ahr 4243 53 a a DT cord-028721-x6f26ahr 4243 54 hCG hcg NN cord-028721-x6f26ahr 4243 55 treatment treatment NN cord-028721-x6f26ahr 4243 56 Altered alter VBN cord-028721-x6f26ahr 4243 57 luteinizing luteinizing JJ cord-028721-x6f26ahr 4243 58 hormone hormone NN cord-028721-x6f26ahr 4243 59 pulsatility pulsatility NN cord-028721-x6f26ahr 4243 60 in in IN cord-028721-x6f26ahr 4243 61 infertile infertile JJ cord-028721-x6f26ahr 4243 62 patients patient NNS cord-028721-x6f26ahr 4243 63 with with IN cord-028721-x6f26ahr 4243 64 idiopathic idiopathic JJ cord-028721-x6f26ahr 4243 65 oligoasthenozoospermia oligoasthenozoospermia NN cord-028721-x6f26ahr 4243 66 Differential differential NN cord-028721-x6f26ahr 4243 67 effect effect NN cord-028721-x6f26ahr 4243 68 of of IN cord-028721-x6f26ahr 4243 69 luteinizing luteinize VBG cord-028721-x6f26ahr 4243 70 hormone hormone NN cord-028721-x6f26ahr 4243 71 - - HYPH cord-028721-x6f26ahr 4243 72 releasing release VBG cord-028721-x6f26ahr 4243 73 hormone hormone NN cord-028721-x6f26ahr 4243 74 infusion infusion NN cord-028721-x6f26ahr 4243 75 on on IN cord-028721-x6f26ahr 4243 76 testicular testicular JJ cord-028721-x6f26ahr 4243 77 steroids steroid NNS cord-028721-x6f26ahr 4243 78 in in IN cord-028721-x6f26ahr 4243 79 normal normal JJ cord-028721-x6f26ahr 4243 80 men man NNS cord-028721-x6f26ahr 4243 81 and and CC cord-028721-x6f26ahr 4243 82 patients patient NNS cord-028721-x6f26ahr 4243 83 with with IN cord-028721-x6f26ahr 4243 84 idiopathic idiopathic JJ cord-028721-x6f26ahr 4243 85 oligospermia oligospermia NN cord-028721-x6f26ahr 4243 86 Molecular molecular JJ cord-028721-x6f26ahr 4243 87 heterogeneity heterogeneity NN cord-028721-x6f26ahr 4243 88 of of IN cord-028721-x6f26ahr 4243 89 serum serum NN cord-028721-x6f26ahr 4243 90 follicle follicle NN cord-028721-x6f26ahr 4243 91 - - HYPH cord-028721-x6f26ahr 4243 92 stimulating stimulate VBG cord-028721-x6f26ahr 4243 93 hormone hormone NN cord-028721-x6f26ahr 4243 94 in in IN cord-028721-x6f26ahr 4243 95 hypogonadal hypogonadal JJ cord-028721-x6f26ahr 4243 96 patients patient NNS cord-028721-x6f26ahr 4243 97 before before IN cord-028721-x6f26ahr 4243 98 and and CC cord-028721-x6f26ahr 4243 99 during during IN cord-028721-x6f26ahr 4243 100 androgen androgen NN cord-028721-x6f26ahr 4243 101 replacement replacement NN cord-028721-x6f26ahr 4243 102 therapy therapy NN cord-028721-x6f26ahr 4243 103 and and CC cord-028721-x6f26ahr 4243 104 in in IN cord-028721-x6f26ahr 4243 105 normal normal JJ cord-028721-x6f26ahr 4243 106 men man NNS cord-028721-x6f26ahr 4243 107 Men man NNS cord-028721-x6f26ahr 4243 108 homozygous homozygous JJ cord-028721-x6f26ahr 4243 109 for for IN cord-028721-x6f26ahr 4243 110 an an DT cord-028721-x6f26ahr 4243 111 inactivating inactivate VBG cord-028721-x6f26ahr 4243 112 mutation mutation NN cord-028721-x6f26ahr 4243 113 of of IN cord-028721-x6f26ahr 4243 114 the the DT cord-028721-x6f26ahr 4243 115 folliclestimulating folliclestimulating NN cord-028721-x6f26ahr 4243 116 - - HYPH cord-028721-x6f26ahr 4243 117 hormone hormone NN cord-028721-x6f26ahr 4243 118 ( ( -LRB- cord-028721-x6f26ahr 4243 119 FSH fsh NN cord-028721-x6f26ahr 4243 120 ) ) -RRB- cord-028721-x6f26ahr 4243 121 receptor receptor NN cord-028721-x6f26ahr 4243 122 gene gene NN cord-028721-x6f26ahr 4243 123 present present JJ cord-028721-x6f26ahr 4243 124 variable variable JJ cord-028721-x6f26ahr 4243 125 suppression suppression NN cord-028721-x6f26ahr 4243 126 of of IN cord-028721-x6f26ahr 4243 127 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4243 128 and and CC cord-028721-x6f26ahr 4243 129 fertility fertility NN cord-028721-x6f26ahr 4244 1 Klassifi Klassifi NNP cord-028721-x6f26ahr 4244 2 zierung zierung NN cord-028721-x6f26ahr 4244 3 tubulärer tubulärer NN cord-028721-x6f26ahr 4244 4 Hodenatrophien Hodenatrophien NNP cord-028721-x6f26ahr 4244 5 bei bei NNP cord-028721-x6f26ahr 4244 6 Sterilitätabklärungen Sterilitätabklärungen NNP cord-028721-x6f26ahr 4244 7 Testicular Testicular NNP cord-028721-x6f26ahr 4244 8 ultrastructure ultrastructure NN cord-028721-x6f26ahr 4244 9 in in IN cord-028721-x6f26ahr 4244 10 infertile infertile JJ cord-028721-x6f26ahr 4244 11 men man NNS cord-028721-x6f26ahr 4244 12 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 4244 13 of of IN cord-028721-x6f26ahr 4244 14 the the DT cord-028721-x6f26ahr 4244 15 nucleus nucleus NN cord-028721-x6f26ahr 4244 16 of of IN cord-028721-x6f26ahr 4244 17 human human JJ cord-028721-x6f26ahr 4244 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 4244 19 cells cell NNS cord-028721-x6f26ahr 4244 20 in in IN cord-028721-x6f26ahr 4244 21 normal normal JJ cord-028721-x6f26ahr 4244 22 and and CC cord-028721-x6f26ahr 4244 23 pathological pathological JJ cord-028721-x6f26ahr 4244 24 testes testis NNS cord-028721-x6f26ahr 4244 25 Evaluation Evaluation NNP cord-028721-x6f26ahr 4244 26 of of IN cord-028721-x6f26ahr 4244 27 the the DT cord-028721-x6f26ahr 4244 28 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4244 29 changes change NNS cord-028721-x6f26ahr 4244 30 in in IN cord-028721-x6f26ahr 4244 31 the the DT cord-028721-x6f26ahr 4244 32 human human JJ cord-028721-x6f26ahr 4244 33 Sertoli Sertoli NNP cord-028721-x6f26ahr 4244 34 cell cell NN cord-028721-x6f26ahr 4244 35 in in IN cord-028721-x6f26ahr 4244 36 testicular testicular JJ cord-028721-x6f26ahr 4244 37 disorders disorder NNS cord-028721-x6f26ahr 4244 38 and and CC cord-028721-x6f26ahr 4244 39 the the DT cord-028721-x6f26ahr 4244 40 relationship relationship NN cord-028721-x6f26ahr 4244 41 of of IN cord-028721-x6f26ahr 4244 42 the the DT cord-028721-x6f26ahr 4244 43 changes change NNS cord-028721-x6f26ahr 4244 44 to to IN cord-028721-x6f26ahr 4244 45 the the DT cord-028721-x6f26ahr 4244 46 levels level NNS cord-028721-x6f26ahr 4244 47 of of IN cord-028721-x6f26ahr 4244 48 serum serum NN cord-028721-x6f26ahr 4244 49 FSH fsh NN cord-028721-x6f26ahr 4244 50 Abnormality abnormality NN cord-028721-x6f26ahr 4244 51 of of IN cord-028721-x6f26ahr 4244 52 testicular testicular JJ cord-028721-x6f26ahr 4244 53 FSH fsh NN cord-028721-x6f26ahr 4244 54 receptors receptor NNS cord-028721-x6f26ahr 4244 55 in in IN cord-028721-x6f26ahr 4244 56 infertile infertile JJ cord-028721-x6f26ahr 4244 57 men man NNS cord-028721-x6f26ahr 4244 58 Signifi Signifi NNP cord-028721-x6f26ahr 4244 59 cance cance NN cord-028721-x6f26ahr 4244 60 of of IN cord-028721-x6f26ahr 4244 61 inhibin inhibin NNP cord-028721-x6f26ahr 4244 62 in in IN cord-028721-x6f26ahr 4244 63 reproductive reproductive JJ cord-028721-x6f26ahr 4244 64 pathophysiology pathophysiology NN cord-028721-x6f26ahr 4244 65 and and CC cord-028721-x6f26ahr 4244 66 current current JJ cord-028721-x6f26ahr 4244 67 clinical clinical JJ cord-028721-x6f26ahr 4244 68 applications application NNS cord-028721-x6f26ahr 4244 69 Placebo Placebo NNP cord-028721-x6f26ahr 4244 70 - - HYPH cord-028721-x6f26ahr 4244 71 controlled control VBN cord-028721-x6f26ahr 4244 72 trial trial NN cord-028721-x6f26ahr 4244 73 of of IN cord-028721-x6f26ahr 4244 74 high high JJ cord-028721-x6f26ahr 4244 75 - - HYPH cord-028721-x6f26ahr 4244 76 dose dose NN cord-028721-x6f26ahr 4244 77 mesterolone mesterolone JJ cord-028721-x6f26ahr 4244 78 treatment treatment NN cord-028721-x6f26ahr 4244 79 of of IN cord-028721-x6f26ahr 4244 80 idiopathic idiopathic JJ cord-028721-x6f26ahr 4244 81 male male JJ cord-028721-x6f26ahr 4244 82 infertility infertility NN cord-028721-x6f26ahr 4244 83 Impaired impair VBD cord-028721-x6f26ahr 4244 84 Leydig Leydig NNP cord-028721-x6f26ahr 4244 85 cell cell NN cord-028721-x6f26ahr 4244 86 function function NN cord-028721-x6f26ahr 4244 87 in in IN cord-028721-x6f26ahr 4244 88 infertile infertile JJ cord-028721-x6f26ahr 4244 89 men man NNS cord-028721-x6f26ahr 4244 90 : : : cord-028721-x6f26ahr 4244 91 a a DT cord-028721-x6f26ahr 4244 92 study study NN cord-028721-x6f26ahr 4244 93 of of IN cord-028721-x6f26ahr 4244 94 357 357 CD cord-028721-x6f26ahr 4244 95 idiopathic idiopathic JJ cord-028721-x6f26ahr 4244 96 infertile infertile JJ cord-028721-x6f26ahr 4244 97 men man NNS cord-028721-x6f26ahr 4244 98 and and CC cord-028721-x6f26ahr 4244 99 318 318 CD cord-028721-x6f26ahr 4244 100 proven prove VBD cord-028721-x6f26ahr 4244 101 fertile fertile JJ cord-028721-x6f26ahr 4244 102 controls control NNS cord-028721-x6f26ahr 4244 103 Leydig Leydig NNP cord-028721-x6f26ahr 4244 104 and and CC cord-028721-x6f26ahr 4244 105 Sertoli Sertoli NNP cord-028721-x6f26ahr 4244 106 cell cell NN cord-028721-x6f26ahr 4244 107 function function NN cord-028721-x6f26ahr 4244 108 in in IN cord-028721-x6f26ahr 4244 109 normal normal JJ cord-028721-x6f26ahr 4244 110 and and CC cord-028721-x6f26ahr 4244 111 oligospermic oligospermic JJ cord-028721-x6f26ahr 4244 112 males male NNS cord-028721-x6f26ahr 4244 113 : : : cord-028721-x6f26ahr 4244 114 a a DT cord-028721-x6f26ahr 4244 115 preliminary preliminary JJ cord-028721-x6f26ahr 4244 116 report report NN cord-028721-x6f26ahr 4244 117 Leydig Leydig NNP cord-028721-x6f26ahr 4244 118 cell cell NN cord-028721-x6f26ahr 4244 119 function function NN cord-028721-x6f26ahr 4244 120 in in IN cord-028721-x6f26ahr 4244 121 infertile infertile JJ cord-028721-x6f26ahr 4244 122 men man NNS cord-028721-x6f26ahr 4244 123 with with IN cord-028721-x6f26ahr 4244 124 idiopathic idiopathic JJ cord-028721-x6f26ahr 4244 125 oligospermic oligospermic JJ cord-028721-x6f26ahr 4244 126 infertility infertility NN cord-028721-x6f26ahr 4244 127 Androgen Androgen NNP cord-028721-x6f26ahr 4244 128 insensitivity insensitivity NN cord-028721-x6f26ahr 4244 129 as as IN cord-028721-x6f26ahr 4244 130 a a DT cord-028721-x6f26ahr 4244 131 cause cause NN cord-028721-x6f26ahr 4244 132 of of IN cord-028721-x6f26ahr 4244 133 infertility infertility NN cord-028721-x6f26ahr 4244 134 in in IN cord-028721-x6f26ahr 4244 135 otherwise otherwise RB cord-028721-x6f26ahr 4244 136 normal normal JJ cord-028721-x6f26ahr 4244 137 men man NNS cord-028721-x6f26ahr 4245 1 The the DT cord-028721-x6f26ahr 4245 2 frequency frequency NN cord-028721-x6f26ahr 4245 3 of of IN cord-028721-x6f26ahr 4245 4 androgen androgen NN cord-028721-x6f26ahr 4245 5 receptor receptor NN cord-028721-x6f26ahr 4245 6 defi defi NNP cord-028721-x6f26ahr 4245 7 ciency ciency NN cord-028721-x6f26ahr 4245 8 in in IN cord-028721-x6f26ahr 4245 9 infertile infertile JJ cord-028721-x6f26ahr 4245 10 men man NNS cord-028721-x6f26ahr 4245 11 Malignant malignant JJ cord-028721-x6f26ahr 4245 12 sex sex NN cord-028721-x6f26ahr 4245 13 cord cord NN cord-028721-x6f26ahr 4245 14 stromal stromal NN cord-028721-x6f26ahr 4245 15 tumor tumor NN cord-028721-x6f26ahr 4245 16 in in IN cord-028721-x6f26ahr 4245 17 a a DT cord-028721-x6f26ahr 4245 18 patient patient NN cord-028721-x6f26ahr 4245 19 with with IN cord-028721-x6f26ahr 4245 20 the the DT cord-028721-x6f26ahr 4245 21 androgen androgen NN cord-028721-x6f26ahr 4245 22 insensitivity insensitivity NN cord-028721-x6f26ahr 4245 23 syndrome syndrome NN cord-028721-x6f26ahr 4246 1 A a DT cord-028721-x6f26ahr 4246 2 new new JJ cord-028721-x6f26ahr 4246 3 point point NN cord-028721-x6f26ahr 4246 4 mutation mutation NN cord-028721-x6f26ahr 4246 5 of of IN cord-028721-x6f26ahr 4246 6 the the DT cord-028721-x6f26ahr 4246 7 androgen androgen NN cord-028721-x6f26ahr 4246 8 receptor receptor NN cord-028721-x6f26ahr 4246 9 gene gene NN cord-028721-x6f26ahr 4246 10 in in IN cord-028721-x6f26ahr 4246 11 a a DT cord-028721-x6f26ahr 4246 12 patient patient NN cord-028721-x6f26ahr 4246 13 with with IN cord-028721-x6f26ahr 4246 14 partial partial JJ cord-028721-x6f26ahr 4246 15 androgen androgen NN cord-028721-x6f26ahr 4246 16 resistance resistance NN cord-028721-x6f26ahr 4246 17 and and CC cord-028721-x6f26ahr 4246 18 severe severe JJ cord-028721-x6f26ahr 4246 19 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 4247 1 The the DT cord-028721-x6f26ahr 4247 2 use use NN cord-028721-x6f26ahr 4247 3 of of IN cord-028721-x6f26ahr 4247 4 clomiphene clomiphene NNP cord-028721-x6f26ahr 4247 5 citrate citrate NNP cord-028721-x6f26ahr 4247 6 in in IN cord-028721-x6f26ahr 4247 7 the the DT cord-028721-x6f26ahr 4247 8 treatment treatment NN cord-028721-x6f26ahr 4247 9 of of IN cord-028721-x6f26ahr 4247 10 azoospermia azoospermia NN cord-028721-x6f26ahr 4247 11 secondary secondary JJ cord-028721-x6f26ahr 4247 12 to to IN cord-028721-x6f26ahr 4247 13 incomplete incomplete JJ cord-028721-x6f26ahr 4247 14 androgen androgen NN cord-028721-x6f26ahr 4247 15 resistance resistance NN cord-028721-x6f26ahr 4247 16 Evidence evidence NN cord-028721-x6f26ahr 4247 17 for for IN cord-028721-x6f26ahr 4247 18 a a DT cord-028721-x6f26ahr 4247 19 partial partial JJ cord-028721-x6f26ahr 4247 20 deletion deletion NN cord-028721-x6f26ahr 4247 21 in in IN cord-028721-x6f26ahr 4247 22 the the DT cord-028721-x6f26ahr 4247 23 androgen androgen NN cord-028721-x6f26ahr 4247 24 receptor receptor NN cord-028721-x6f26ahr 4247 25 gene gene NN cord-028721-x6f26ahr 4247 26 in in IN cord-028721-x6f26ahr 4247 27 a a DT cord-028721-x6f26ahr 4247 28 phenotypic phenotypic JJ cord-028721-x6f26ahr 4247 29 male male NN cord-028721-x6f26ahr 4247 30 with with IN cord-028721-x6f26ahr 4247 31 azoospermia azoospermia NN cord-028721-x6f26ahr 4247 32 Androgen Androgen NNP cord-028721-x6f26ahr 4247 33 insensitivity insensitivity NN cord-028721-x6f26ahr 4247 34 and and CC cord-028721-x6f26ahr 4247 35 male male JJ cord-028721-x6f26ahr 4247 36 infertility infertility NN cord-028721-x6f26ahr 4247 37 Frequency frequency NN cord-028721-x6f26ahr 4247 38 of of IN cord-028721-x6f26ahr 4247 39 androgen androgen NN cord-028721-x6f26ahr 4247 40 insensitivity insensitivity NN cord-028721-x6f26ahr 4247 41 infertile infertile JJ cord-028721-x6f26ahr 4247 42 phenotypically phenotypically RB cord-028721-x6f26ahr 4247 43 normal normal JJ cord-028721-x6f26ahr 4247 44 men man NNS cord-028721-x6f26ahr 4247 45 Improvement improvement NN cord-028721-x6f26ahr 4247 46 of of IN cord-028721-x6f26ahr 4247 47 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4247 48 after after IN cord-028721-x6f26ahr 4247 49 treatment treatment NN cord-028721-x6f26ahr 4247 50 with with IN cord-028721-x6f26ahr 4247 51 the the DT cord-028721-x6f26ahr 4247 52 antiestrogen antiestrogen NNP cord-028721-x6f26ahr 4247 53 tamoxifen tamoxifen NNP cord-028721-x6f26ahr 4247 54 in in IN cord-028721-x6f26ahr 4247 55 a a DT cord-028721-x6f26ahr 4247 56 man man NN cord-028721-x6f26ahr 4247 57 with with IN cord-028721-x6f26ahr 4247 58 the the DT cord-028721-x6f26ahr 4247 59 incomplete incomplete JJ cord-028721-x6f26ahr 4247 60 androgen androgen NN cord-028721-x6f26ahr 4247 61 insensitivity insensitivity NN cord-028721-x6f26ahr 4247 62 syndrome syndrome NN cord-028721-x6f26ahr 4248 1 A a DT cord-028721-x6f26ahr 4248 2 controlled control VBN cord-028721-x6f26ahr 4248 3 comparison comparison NN cord-028721-x6f26ahr 4248 4 of of IN cord-028721-x6f26ahr 4248 5 the the DT cord-028721-x6f26ahr 4248 6 effi effi NNP cord-028721-x6f26ahr 4248 7 cacy cacy NNP cord-028721-x6f26ahr 4248 8 of of IN cord-028721-x6f26ahr 4248 9 clomiphene clomiphene NNP cord-028721-x6f26ahr 4248 10 citrate citrate NNP cord-028721-x6f26ahr 4248 11 in in IN cord-028721-x6f26ahr 4248 12 male male JJ cord-028721-x6f26ahr 4248 13 infertility infertility NN cord-028721-x6f26ahr 4248 14 Pregnancy pregnancy NN cord-028721-x6f26ahr 4248 15 after after IN cord-028721-x6f26ahr 4248 16 hormonal hormonal JJ cord-028721-x6f26ahr 4248 17 correction correction NN cord-028721-x6f26ahr 4248 18 of of IN cord-028721-x6f26ahr 4248 19 severe severe JJ cord-028721-x6f26ahr 4248 20 spermatogenic spermatogenic NN cord-028721-x6f26ahr 4248 21 defect defect NN cord-028721-x6f26ahr 4248 22 due due IN cord-028721-x6f26ahr 4248 23 to to IN cord-028721-x6f26ahr 4248 24 a a DT cord-028721-x6f26ahr 4248 25 mutation mutation NN cord-028721-x6f26ahr 4248 26 in in IN cord-028721-x6f26ahr 4248 27 androgen androgen NN cord-028721-x6f26ahr 4248 28 receptor receptor NN cord-028721-x6f26ahr 4248 29 gene gene NN cord-028721-x6f26ahr 4248 30 Occupational Occupational NNP cord-028721-x6f26ahr 4248 31 exposures exposure NNS cord-028721-x6f26ahr 4248 32 associated associate VBN cord-028721-x6f26ahr 4248 33 with with IN cord-028721-x6f26ahr 4248 34 male male JJ cord-028721-x6f26ahr 4248 35 reproductive reproductive JJ cord-028721-x6f26ahr 4248 36 dysfunction dysfunction NN cord-028721-x6f26ahr 4248 37 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4248 38 surface surface NN cord-028721-x6f26ahr 4248 39 characteristics characteristic NNS cord-028721-x6f26ahr 4248 40 of of IN cord-028721-x6f26ahr 4248 41 seminiferous seminiferous JJ cord-028721-x6f26ahr 4248 42 tubules tubule NNS cord-028721-x6f26ahr 4248 43 from from IN cord-028721-x6f26ahr 4248 44 men man NNS cord-028721-x6f26ahr 4248 45 with with IN cord-028721-x6f26ahr 4248 46 varicocele varicocele FW cord-028721-x6f26ahr 4248 47 Signifi Signifi NNP cord-028721-x6f26ahr 4248 48 cance cance NN cord-028721-x6f26ahr 4248 49 of of IN cord-028721-x6f26ahr 4248 50 testicular testicular JJ cord-028721-x6f26ahr 4248 51 size size NN cord-028721-x6f26ahr 4248 52 measurement measurement NN cord-028721-x6f26ahr 4248 53 in in IN cord-028721-x6f26ahr 4248 54 andrology andrology NN cord-028721-x6f26ahr 4248 55 . . . cord-028721-x6f26ahr 4249 1 II II NNP cord-028721-x6f26ahr 4249 2 . . . cord-028721-x6f26ahr 4250 1 Correlation correlation NN cord-028721-x6f26ahr 4250 2 of of IN cord-028721-x6f26ahr 4250 3 testicular testicular JJ cord-028721-x6f26ahr 4250 4 size size NN cord-028721-x6f26ahr 4250 5 with with IN cord-028721-x6f26ahr 4250 6 testicular testicular NN cord-028721-x6f26ahr 4250 7 function function NN cord-028721-x6f26ahr 4250 8 Deterioration deterioration NN cord-028721-x6f26ahr 4250 9 of of IN cord-028721-x6f26ahr 4250 10 semen semen NN cord-028721-x6f26ahr 4250 11 parameters parameter NNS cord-028721-x6f26ahr 4250 12 over over IN cord-028721-x6f26ahr 4250 13 time time NN cord-028721-x6f26ahr 4250 14 in in IN cord-028721-x6f26ahr 4250 15 men man NNS cord-028721-x6f26ahr 4250 16 with with IN cord-028721-x6f26ahr 4250 17 untreated untreated JJ cord-028721-x6f26ahr 4250 18 varicocele varicocele NN cord-028721-x6f26ahr 4250 19 : : : cord-028721-x6f26ahr 4251 1 evidence evidence NN cord-028721-x6f26ahr 4251 2 of of IN cord-028721-x6f26ahr 4251 3 progressive progressive JJ cord-028721-x6f26ahr 4251 4 testicular testicular NNP cord-028721-x6f26ahr 4251 5 damage damage NN cord-028721-x6f26ahr 4251 6 Quantitative quantitative JJ cord-028721-x6f26ahr 4251 7 evaluation evaluation NN cord-028721-x6f26ahr 4251 8 of of IN cord-028721-x6f26ahr 4251 9 testicular testicular JJ cord-028721-x6f26ahr 4251 10 biopsies biopsy NNS cord-028721-x6f26ahr 4251 11 in in IN cord-028721-x6f26ahr 4251 12 varicocele varicocele NN cord-028721-x6f26ahr 4251 13 Testis Testis NNP cord-028721-x6f26ahr 4251 14 biopsy biopsy NN cord-028721-x6f26ahr 4251 15 in in IN cord-028721-x6f26ahr 4251 16 subfertile subfertile NNP cord-028721-x6f26ahr 4251 17 men man NNS cord-028721-x6f26ahr 4251 18 with with IN cord-028721-x6f26ahr 4251 19 varicocele varicocele NN cord-028721-x6f26ahr 4251 20 Testicular Testicular NNP cord-028721-x6f26ahr 4251 21 changes change NNS cord-028721-x6f26ahr 4251 22 in in IN cord-028721-x6f26ahr 4251 23 subfertile subfertile NN cord-028721-x6f26ahr 4251 24 males male NNS cord-028721-x6f26ahr 4251 25 with with IN cord-028721-x6f26ahr 4251 26 varicocele varicocele NN cord-028721-x6f26ahr 4251 27 Classifi Classifi NNP cord-028721-x6f26ahr 4251 28 cation cation NN cord-028721-x6f26ahr 4251 29 of of IN cord-028721-x6f26ahr 4251 30 several several JJ cord-028721-x6f26ahr 4251 31 types type NNS cord-028721-x6f26ahr 4251 32 of of IN cord-028721-x6f26ahr 4251 33 maturational maturational JJ cord-028721-x6f26ahr 4251 34 arrest arrest NN cord-028721-x6f26ahr 4251 35 of of IN cord-028721-x6f26ahr 4251 36 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 4251 37 according accord VBG cord-028721-x6f26ahr 4251 38 to to IN cord-028721-x6f26ahr 4251 39 Sertoli sertoli JJ cord-028721-x6f26ahr 4251 40 cell cell NN cord-028721-x6f26ahr 4251 41 morphology morphology NN cord-028721-x6f26ahr 4251 42 : : : cord-028721-x6f26ahr 4251 43 an an DT cord-028721-x6f26ahr 4251 44 approach approach NN cord-028721-x6f26ahr 4251 45 to to IN cord-028721-x6f26ahr 4251 46 aetiology aetiology NN cord-028721-x6f26ahr 4251 47 Prostate prostate NN cord-028721-x6f26ahr 4251 48 cancer cancer NN cord-028721-x6f26ahr 4251 49 . . . cord-028721-x6f26ahr 4252 1 Primary primary JJ cord-028721-x6f26ahr 4252 2 hormonal hormonal JJ cord-028721-x6f26ahr 4252 3 treatment treatment NN cord-028721-x6f26ahr 4252 4 Focal focal JJ cord-028721-x6f26ahr 4252 5 atrophy atrophy NN cord-028721-x6f26ahr 4252 6 of of IN cord-028721-x6f26ahr 4252 7 the the DT cord-028721-x6f26ahr 4252 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 4252 9 tubule tubule NN cord-028721-x6f26ahr 4252 10 in in IN cord-028721-x6f26ahr 4252 11 the the DT cord-028721-x6f26ahr 4252 12 human human JJ cord-028721-x6f26ahr 4252 13 testis testis NN cord-028721-x6f26ahr 4252 14 Quantitative quantitative JJ cord-028721-x6f26ahr 4252 15 and and CC cord-028721-x6f26ahr 4252 16 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4252 17 study study NN cord-028721-x6f26ahr 4252 18 on on IN cord-028721-x6f26ahr 4252 19 germinal germinal JJ cord-028721-x6f26ahr 4252 20 epithelium epithelium NN cord-028721-x6f26ahr 4252 21 in in IN cord-028721-x6f26ahr 4252 22 testicular testicular JJ cord-028721-x6f26ahr 4252 23 biopsies biopsy NNS cord-028721-x6f26ahr 4252 24 with with IN cord-028721-x6f26ahr 4252 25 ' ' `` cord-028721-x6f26ahr 4252 26 mixed mixed JJ cord-028721-x6f26ahr 4252 27 atrophy atrophy NN cord-028721-x6f26ahr 4252 28 Proliferation proliferation NN cord-028721-x6f26ahr 4252 29 and and CC cord-028721-x6f26ahr 4252 30 functional functional JJ cord-028721-x6f26ahr 4252 31 maturation maturation NN cord-028721-x6f26ahr 4252 32 of of IN cord-028721-x6f26ahr 4252 33 Sertoli Sertoli NNP cord-028721-x6f26ahr 4252 34 cells cell NNS cord-028721-x6f26ahr 4252 35 , , , cord-028721-x6f26ahr 4252 36 and and CC cord-028721-x6f26ahr 4252 37 their -PRON- PRP$ cord-028721-x6f26ahr 4252 38 relevance relevance NN cord-028721-x6f26ahr 4252 39 to to IN cord-028721-x6f26ahr 4252 40 disorders disorder NNS cord-028721-x6f26ahr 4252 41 of of IN cord-028721-x6f26ahr 4252 42 testis testis NN cord-028721-x6f26ahr 4252 43 function function NN cord-028721-x6f26ahr 4252 44 in in IN cord-028721-x6f26ahr 4252 45 adulthood adulthood NN cord-028721-x6f26ahr 4252 46 Return return NN cord-028721-x6f26ahr 4252 47 of of IN cord-028721-x6f26ahr 4252 48 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4252 49 after after IN cord-028721-x6f26ahr 4252 50 stopping stop VBG cord-028721-x6f26ahr 4252 51 cyclophosphamide cyclophosphamide NN cord-028721-x6f26ahr 4252 52 therapy therapy NN cord-028721-x6f26ahr 4253 1 The the DT cord-028721-x6f26ahr 4253 2 frequency frequency NN cord-028721-x6f26ahr 4253 3 and and CC cord-028721-x6f26ahr 4253 4 morphology morphology NN cord-028721-x6f26ahr 4253 5 of of IN cord-028721-x6f26ahr 4253 6 ' ' `` cord-028721-x6f26ahr 4253 7 giant giant JJ cord-028721-x6f26ahr 4253 8 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 4253 9 ' ' '' cord-028721-x6f26ahr 4253 10 in in IN cord-028721-x6f26ahr 4253 11 the the DT cord-028721-x6f26ahr 4253 12 human human JJ cord-028721-x6f26ahr 4253 13 testis testis NN cord-028721-x6f26ahr 4253 14 Seminiferous seminiferous JJ cord-028721-x6f26ahr 4253 15 tubule tubule NN cord-028721-x6f26ahr 4253 16 involution involution NN cord-028721-x6f26ahr 4253 17 in in IN cord-028721-x6f26ahr 4253 18 elderly elderly JJ cord-028721-x6f26ahr 4253 19 men man NNS cord-028721-x6f26ahr 4253 20 Pattern pattern NN cord-028721-x6f26ahr 4253 21 of of IN cord-028721-x6f26ahr 4253 22 compartmentation compartmentation NN cord-028721-x6f26ahr 4253 23 in in IN cord-028721-x6f26ahr 4253 24 human human JJ cord-028721-x6f26ahr 4253 25 seminiferous seminiferous JJ cord-028721-x6f26ahr 4253 26 tubules tubule NNS cord-028721-x6f26ahr 4253 27 showing show VBG cord-028721-x6f26ahr 4253 28 dislocation dislocation NN cord-028721-x6f26ahr 4253 29 of of IN cord-028721-x6f26ahr 4253 30 spermatogonia spermatogonia NNP cord-028721-x6f26ahr 4253 31 Dislocated dislocate VBN cord-028721-x6f26ahr 4253 32 type type NN cord-028721-x6f26ahr 4253 33 - - : cord-028721-x6f26ahr 4253 34 A a DT cord-028721-x6f26ahr 4253 35 spermatogonia spermatogonia NN cord-028721-x6f26ahr 4253 36 in in IN cord-028721-x6f26ahr 4253 37 human human JJ cord-028721-x6f26ahr 4253 38 seminiferous seminiferous JJ cord-028721-x6f26ahr 4253 39 tubules tubule NNS cord-028721-x6f26ahr 4253 40 Intercellular Intercellular NNP cord-028721-x6f26ahr 4253 41 bridges bridge NNS cord-028721-x6f26ahr 4253 42 between between IN cord-028721-x6f26ahr 4253 43 megalospermatocytes megalospermatocyte NNS cord-028721-x6f26ahr 4253 44 in in IN cord-028721-x6f26ahr 4253 45 the the DT cord-028721-x6f26ahr 4253 46 human human JJ cord-028721-x6f26ahr 4253 47 testis testis NN cord-028721-x6f26ahr 4253 48 Megalospermatocytes Megalospermatocytes NNPS cord-028721-x6f26ahr 4253 49 in in IN cord-028721-x6f26ahr 4253 50 the the DT cord-028721-x6f26ahr 4253 51 human human JJ cord-028721-x6f26ahr 4253 52 testis testis NN cord-028721-x6f26ahr 4253 53 exhibit exhibit NNP cord-028721-x6f26ahr 4253 54 asynapsis asynapsis NN cord-028721-x6f26ahr 4253 55 of of IN cord-028721-x6f26ahr 4253 56 chromosomes chromosome NNS cord-028721-x6f26ahr 4253 57 Megalospermatocytes Megalospermatocytes NNPS cord-028721-x6f26ahr 4253 58 : : : cord-028721-x6f26ahr 4253 59 indicators indicator NNS cord-028721-x6f26ahr 4253 60 of of IN cord-028721-x6f26ahr 4253 61 disturbed disturbed JJ cord-028721-x6f26ahr 4253 62 meiosis meiosis NN cord-028721-x6f26ahr 4253 63 in in IN cord-028721-x6f26ahr 4253 64 man man NN cord-028721-x6f26ahr 4253 65 Multinucleate Multinucleate NNP cord-028721-x6f26ahr 4253 66 spermatids spermatid NNS cord-028721-x6f26ahr 4253 67 in in IN cord-028721-x6f26ahr 4253 68 aging age VBG cord-028721-x6f26ahr 4253 69 human human JJ cord-028721-x6f26ahr 4253 70 testes testis NNS cord-028721-x6f26ahr 4253 71 Unusual unusual JJ cord-028721-x6f26ahr 4253 72 incidence incidence NN cord-028721-x6f26ahr 4253 73 of of IN cord-028721-x6f26ahr 4253 74 binucleate binucleate NNP cord-028721-x6f26ahr 4253 75 spermatids spermatids NNP cord-028721-x6f26ahr 4253 76 in in IN cord-028721-x6f26ahr 4253 77 human human JJ cord-028721-x6f26ahr 4253 78 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4253 79 Testicular Testicular NNP cord-028721-x6f26ahr 4253 80 and and CC cord-028721-x6f26ahr 4253 81 epididymal epididymal JJ cord-028721-x6f26ahr 4253 82 pathology pathology NN cord-028721-x6f26ahr 4254 1 Spermatogenetic spermatogenetic JJ cord-028721-x6f26ahr 4254 2 arrest arrest NN cord-028721-x6f26ahr 4254 3 with with IN cord-028721-x6f26ahr 4254 4 inhibition inhibition NN cord-028721-x6f26ahr 4254 5 of of IN cord-028721-x6f26ahr 4254 6 acrosome acrosome NN cord-028721-x6f26ahr 4254 7 and and CC cord-028721-x6f26ahr 4254 8 sperm sperm NN cord-028721-x6f26ahr 4254 9 tail tail NN cord-028721-x6f26ahr 4254 10 development development NN cord-028721-x6f26ahr 4255 1 Recent recent JJ cord-028721-x6f26ahr 4255 2 advances advance NNS cord-028721-x6f26ahr 4255 3 in in IN cord-028721-x6f26ahr 4255 4 human human JJ cord-028721-x6f26ahr 4255 5 sperm sperm NN cord-028721-x6f26ahr 4255 6 pathology pathology NN cord-028721-x6f26ahr 4255 7 Anomalies Anomalies NNPS cord-028721-x6f26ahr 4255 8 morphologiques morphologiques NNP cord-028721-x6f26ahr 4255 9 du du NNP cord-028721-x6f26ahr 4255 10 spermatozoide spermatozoide NNP cord-028721-x6f26ahr 4255 11 humain humain NNP cord-028721-x6f26ahr 4255 12 . . . cord-028721-x6f26ahr 4256 1 Propositions proposition NNS cord-028721-x6f26ahr 4256 2 pour pour VBP cord-028721-x6f26ahr 4256 3 un un NNP cord-028721-x6f26ahr 4256 4 système système NNP cord-028721-x6f26ahr 4256 5 de de NNP cord-028721-x6f26ahr 4256 6 classifi classifi NNP cord-028721-x6f26ahr 4256 7 cation cation NN cord-028721-x6f26ahr 4256 8 Morphologische Morphologische NNP cord-028721-x6f26ahr 4256 9 Studien Studien NNP cord-028721-x6f26ahr 4256 10 an an DT cord-028721-x6f26ahr 4256 11 abnormen abnormen NN cord-028721-x6f26ahr 4257 1 Spermatiden Spermatiden NNP cord-028721-x6f26ahr 4257 2 und und IN cord-028721-x6f26ahr 4257 3 Spermatozoen Spermatozoen NNP cord-028721-x6f26ahr 4257 4 des des FW cord-028721-x6f26ahr 4257 5 Menschen Menschen NNP cord-028721-x6f26ahr 4257 6 Classifi Classifi NNP cord-028721-x6f26ahr 4257 7 cation cation NN cord-028721-x6f26ahr 4257 8 of of IN cord-028721-x6f26ahr 4257 9 abnormalities abnormality NNS cord-028721-x6f26ahr 4257 10 in in IN cord-028721-x6f26ahr 4257 11 human human JJ cord-028721-x6f26ahr 4257 12 spermatids spermatid NNS cord-028721-x6f26ahr 4257 13 based base VBN cord-028721-x6f26ahr 4257 14 on on IN cord-028721-x6f26ahr 4257 15 recent recent JJ cord-028721-x6f26ahr 4257 16 advances advance NNS cord-028721-x6f26ahr 4257 17 in in IN cord-028721-x6f26ahr 4257 18 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4257 19 research research NN cord-028721-x6f26ahr 4257 20 on on IN cord-028721-x6f26ahr 4257 21 spermatid spermatid JJ cord-028721-x6f26ahr 4257 22 differentiation differentiation NN cord-028721-x6f26ahr 4257 23 Morphology morphology NN cord-028721-x6f26ahr 4257 24 of of IN cord-028721-x6f26ahr 4257 25 spermatozoa spermatozoa VBG cord-028721-x6f26ahr 4257 26 in in IN cord-028721-x6f26ahr 4257 27 fertile fertile JJ cord-028721-x6f26ahr 4257 28 man man NN cord-028721-x6f26ahr 4257 29 with with IN cord-028721-x6f26ahr 4257 30 and and CC cord-028721-x6f26ahr 4257 31 without without IN cord-028721-x6f26ahr 4257 32 varicocele varicocele NN cord-028721-x6f26ahr 4258 1 On on IN cord-028721-x6f26ahr 4258 2 round round JJ cord-028721-x6f26ahr 4258 3 headed head VBN cord-028721-x6f26ahr 4258 4 human human JJ cord-028721-x6f26ahr 4258 5 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 4258 6 Morphogenesis Morphogenesis NNP cord-028721-x6f26ahr 4258 7 of of IN cord-028721-x6f26ahr 4258 8 round round JJ cord-028721-x6f26ahr 4258 9 headed head VBN cord-028721-x6f26ahr 4258 10 human human JJ cord-028721-x6f26ahr 4258 11 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4258 12 lacking lack VBG cord-028721-x6f26ahr 4258 13 acrosomes acrosome NNS cord-028721-x6f26ahr 4258 14 in in IN cord-028721-x6f26ahr 4258 15 a a DT cord-028721-x6f26ahr 4258 16 case case NN cord-028721-x6f26ahr 4258 17 of of IN cord-028721-x6f26ahr 4258 18 severe severe JJ cord-028721-x6f26ahr 4258 19 teratozoospermia teratozoospermia NN cord-028721-x6f26ahr 4258 20 Sperm sperm NN cord-028721-x6f26ahr 4258 21 acrosome acrosome NN cord-028721-x6f26ahr 4258 22 defects defect VBZ cord-028721-x6f26ahr 4258 23 in in IN cord-028721-x6f26ahr 4258 24 a a DT cord-028721-x6f26ahr 4258 25 patient patient NN cord-028721-x6f26ahr 4258 26 with with IN cord-028721-x6f26ahr 4258 27 Aarskog Aarskog NNP cord-028721-x6f26ahr 4258 28 - - HYPH cord-028721-x6f26ahr 4258 29 Scott Scott NNP cord-028721-x6f26ahr 4258 30 syndrome syndrome NN cord-028721-x6f26ahr 4258 31 Failure failure NN cord-028721-x6f26ahr 4258 32 of of IN cord-028721-x6f26ahr 4258 33 differentiation differentiation NN cord-028721-x6f26ahr 4258 34 of of IN cord-028721-x6f26ahr 4258 35 the the DT cord-028721-x6f26ahr 4258 36 nuclear nuclear JJ cord-028721-x6f26ahr 4258 37 - - HYPH cord-028721-x6f26ahr 4258 38 perinuclear perinuclear NN cord-028721-x6f26ahr 4258 39 skeletal skeletal JJ cord-028721-x6f26ahr 4258 40 complex complex NN cord-028721-x6f26ahr 4258 41 in in IN cord-028721-x6f26ahr 4258 42 the the DT cord-028721-x6f26ahr 4258 43 round round RB cord-028721-x6f26ahr 4258 44 - - HYPH cord-028721-x6f26ahr 4258 45 headed head VBN cord-028721-x6f26ahr 4258 46 human human JJ cord-028721-x6f26ahr 4258 47 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 4258 48 Human human JJ cord-028721-x6f26ahr 4258 49 sperm sperm NN cord-028721-x6f26ahr 4258 50 acrosin acrosin NN cord-028721-x6f26ahr 4258 51 activity activity NN cord-028721-x6f26ahr 4258 52 with with IN cord-028721-x6f26ahr 4258 53 relation relation NN cord-028721-x6f26ahr 4258 54 to to IN cord-028721-x6f26ahr 4258 55 semen semen NN cord-028721-x6f26ahr 4258 56 parameters parameter NNS cord-028721-x6f26ahr 4258 57 and and CC cord-028721-x6f26ahr 4258 58 acrosomal acrosomal JJ cord-028721-x6f26ahr 4258 59 ultrastructure ultrastructure NN cord-028721-x6f26ahr 4258 60 Chromosome chromosome NN cord-028721-x6f26ahr 4258 61 aneuploidy aneuploidy NN cord-028721-x6f26ahr 4258 62 in in IN cord-028721-x6f26ahr 4258 63 the the DT cord-028721-x6f26ahr 4258 64 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4258 65 of of IN cord-028721-x6f26ahr 4258 66 two two CD cord-028721-x6f26ahr 4258 67 men man NNS cord-028721-x6f26ahr 4258 68 with with IN cord-028721-x6f26ahr 4258 69 globozoospermia globozoospermia NNP cord-028721-x6f26ahr 4258 70 Sperm Sperm NNP cord-028721-x6f26ahr 4258 71 chromosome chromosome NN cord-028721-x6f26ahr 4258 72 aneuploidy aneuploidy NN cord-028721-x6f26ahr 4258 73 analysis analysis NN cord-028721-x6f26ahr 4258 74 in in IN cord-028721-x6f26ahr 4258 75 a a DT cord-028721-x6f26ahr 4258 76 man man NN cord-028721-x6f26ahr 4258 77 with with IN cord-028721-x6f26ahr 4258 78 globozoospermia globozoospermia NNP cord-028721-x6f26ahr 4258 79 Round Round NNP cord-028721-x6f26ahr 4258 80 head head NN cord-028721-x6f26ahr 4258 81 ' ' '' cord-028721-x6f26ahr 4258 82 sperm sperm NN cord-028721-x6f26ahr 4258 83 defect defect NN cord-028721-x6f26ahr 4258 84 . . . cord-028721-x6f26ahr 4259 1 Ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4259 2 and and CC cord-028721-x6f26ahr 4259 3 meiotic meiotic JJ cord-028721-x6f26ahr 4259 4 segregation segregation NN cord-028721-x6f26ahr 4259 5 study study NN cord-028721-x6f26ahr 4259 6 Lack Lack NNP cord-028721-x6f26ahr 4259 7 of of IN cord-028721-x6f26ahr 4259 8 acrosome acrosome NN cord-028721-x6f26ahr 4259 9 formation formation NN cord-028721-x6f26ahr 4259 10 in in IN cord-028721-x6f26ahr 4259 11 mice mouse NNS cord-028721-x6f26ahr 4259 12 lacking lack VBG cord-028721-x6f26ahr 4259 13 a a DT cord-028721-x6f26ahr 4259 14 Golgi Golgi NNP cord-028721-x6f26ahr 4259 15 protein protein NN cord-028721-x6f26ahr 4259 16 Human human JJ cord-028721-x6f26ahr 4259 17 infertility infertility NN cord-028721-x6f26ahr 4259 18 due due IN cord-028721-x6f26ahr 4259 19 to to IN cord-028721-x6f26ahr 4259 20 production production NN cord-028721-x6f26ahr 4259 21 of of IN cord-028721-x6f26ahr 4259 22 multiple multiple JJ cord-028721-x6f26ahr 4259 23 - - HYPH cord-028721-x6f26ahr 4259 24 tailed tailed JJ cord-028721-x6f26ahr 4259 25 References reference NNS cord-028721-x6f26ahr 4259 26 spermatozoa spermatozoa VBP cord-028721-x6f26ahr 4259 27 with with IN cord-028721-x6f26ahr 4259 28 excessive excessive JJ cord-028721-x6f26ahr 4259 29 amounts amount NNS cord-028721-x6f26ahr 4259 30 of of IN cord-028721-x6f26ahr 4259 31 DNA DNA NNP cord-028721-x6f26ahr 4259 32 Multi multi JJ cord-028721-x6f26ahr 4259 33 - - HYPH cord-028721-x6f26ahr 4259 34 tailed tailed JJ cord-028721-x6f26ahr 4259 35 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4259 36 in in IN cord-028721-x6f26ahr 4259 37 a a DT cord-028721-x6f26ahr 4259 38 case case NN cord-028721-x6f26ahr 4259 39 with with IN cord-028721-x6f26ahr 4259 40 asthenospermia asthenospermia NNP cord-028721-x6f26ahr 4259 41 and and CC cord-028721-x6f26ahr 4259 42 teratospermia teratospermia NNP cord-028721-x6f26ahr 4259 43 Human Human NNP cord-028721-x6f26ahr 4259 44 spermatozoa spermatozoa VBP cord-028721-x6f26ahr 4259 45 with with IN cord-028721-x6f26ahr 4259 46 large large JJ cord-028721-x6f26ahr 4259 47 heads head NNS cord-028721-x6f26ahr 4259 48 and and CC cord-028721-x6f26ahr 4259 49 multiple multiple JJ cord-028721-x6f26ahr 4259 50 fl fl NNP cord-028721-x6f26ahr 4259 51 agella agella NNS cord-028721-x6f26ahr 4259 52 : : : cord-028721-x6f26ahr 4259 53 a a DT cord-028721-x6f26ahr 4259 54 quantitative quantitative JJ cord-028721-x6f26ahr 4259 55 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4259 56 study study NN cord-028721-x6f26ahr 4259 57 of of IN cord-028721-x6f26ahr 4259 58 6 6 CD cord-028721-x6f26ahr 4259 59 cases case NNS cord-028721-x6f26ahr 4259 60 Chromosomal chromosomal JJ cord-028721-x6f26ahr 4259 61 analysis analysis NN cord-028721-x6f26ahr 4259 62 of of IN cord-028721-x6f26ahr 4259 63 spermatozoa spermatozoa VBG cord-028721-x6f26ahr 4259 64 with with IN cord-028721-x6f26ahr 4259 65 normal normal JJ cord-028721-x6f26ahr 4259 66 - - HYPH cord-028721-x6f26ahr 4259 67 sized sized JJ cord-028721-x6f26ahr 4259 68 heads head NNS cord-028721-x6f26ahr 4259 69 in in IN cord-028721-x6f26ahr 4259 70 two two CD cord-028721-x6f26ahr 4259 71 infertile infertile JJ cord-028721-x6f26ahr 4259 72 patients patient NNS cord-028721-x6f26ahr 4259 73 with with IN cord-028721-x6f26ahr 4259 74 macrocephalic macrocephalic NNP cord-028721-x6f26ahr 4259 75 sperm sperm NNP cord-028721-x6f26ahr 4259 76 head head NN cord-028721-x6f26ahr 4259 77 syndrome syndrome NN cord-028721-x6f26ahr 4259 78 Crater Crater NNP cord-028721-x6f26ahr 4259 79 defect defect NN cord-028721-x6f26ahr 4259 80 in in IN cord-028721-x6f26ahr 4259 81 human human JJ cord-028721-x6f26ahr 4259 82 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 4259 83 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4259 84 study study NN cord-028721-x6f26ahr 4259 85 of of IN cord-028721-x6f26ahr 4259 86 human human JJ cord-028721-x6f26ahr 4259 87 binucleate binucleate NNP cord-028721-x6f26ahr 4259 88 spermatids spermatids NNP cord-028721-x6f26ahr 4259 89 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4259 90 abnormalities abnormality NNS cord-028721-x6f26ahr 4259 91 of of IN cord-028721-x6f26ahr 4259 92 human human JJ cord-028721-x6f26ahr 4259 93 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4259 94 Cytoplasmic Cytoplasmic NNP cord-028721-x6f26ahr 4259 95 droplets droplet NNS cord-028721-x6f26ahr 4259 96 : : : cord-028721-x6f26ahr 4259 97 the the DT cord-028721-x6f26ahr 4259 98 good good NN cord-028721-x6f26ahr 4259 99 , , , cord-028721-x6f26ahr 4259 100 the the DT cord-028721-x6f26ahr 4259 101 bad bad JJ cord-028721-x6f26ahr 4259 102 or or CC cord-028721-x6f26ahr 4259 103 just just RB cord-028721-x6f26ahr 4259 104 confusing confusing JJ cord-028721-x6f26ahr 4259 105 ? ? . cord-028721-x6f26ahr 4260 1 Absence absence NN cord-028721-x6f26ahr 4260 2 de de FW cord-028721-x6f26ahr 4260 3 la la FW cord-028721-x6f26ahr 4260 4 paire paire NNP cord-028721-x6f26ahr 4260 5 centrale centrale NNP cord-028721-x6f26ahr 4260 6 du du NNP cord-028721-x6f26ahr 4261 1 complexe complexe NNP cord-028721-x6f26ahr 4262 1 axonemique axonemique NNP cord-028721-x6f26ahr 4262 2 dans dans FW cord-028721-x6f26ahr 4262 3 une une FW cord-028721-x6f26ahr 4262 4 tératospermie tératospermie FW cord-028721-x6f26ahr 4262 5 avec avec NNP cord-028721-x6f26ahr 4262 6 fl fl NNP cord-028721-x6f26ahr 4262 7 agelles agelles NNP cord-028721-x6f26ahr 4262 8 courts court NNS cord-028721-x6f26ahr 4262 9 et et NNP cord-028721-x6f26ahr 4263 1 épais épais NNP cord-028721-x6f26ahr 4263 2 Asthenozoospermie Asthenozoospermie NNP cord-028721-x6f26ahr 4263 3 totale totale NNP cord-028721-x6f26ahr 4263 4 avec avec FW cord-028721-x6f26ahr 4263 5 anomalie anomalie NNP cord-028721-x6f26ahr 4263 6 ultrastructurale ultrastructurale NNP cord-028721-x6f26ahr 4263 7 du du NNP cord-028721-x6f26ahr 4263 8 fl fl NNP cord-028721-x6f26ahr 4263 9 agelle agelle NNP cord-028721-x6f26ahr 4263 10 dans dans FW cord-028721-x6f26ahr 4263 11 deux deux FW cord-028721-x6f26ahr 4263 12 frères frères NNP cord-028721-x6f26ahr 4263 13 stériles stériles NNP cord-028721-x6f26ahr 4263 14 Dysplasia Dysplasia NNP cord-028721-x6f26ahr 4263 15 of of IN cord-028721-x6f26ahr 4263 16 the the DT cord-028721-x6f26ahr 4263 17 fi fi NNP cord-028721-x6f26ahr 4263 18 brous brous JJ cord-028721-x6f26ahr 4263 19 sheath sheath NN cord-028721-x6f26ahr 4263 20 . . . cord-028721-x6f26ahr 4264 1 An an DT cord-028721-x6f26ahr 4264 2 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4264 3 defect defect NN cord-028721-x6f26ahr 4264 4 of of IN cord-028721-x6f26ahr 4264 5 human human JJ cord-028721-x6f26ahr 4264 6 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4264 7 associated associate VBN cord-028721-x6f26ahr 4264 8 with with IN cord-028721-x6f26ahr 4264 9 sperm sperm NN cord-028721-x6f26ahr 4264 10 immotility immotility NN cord-028721-x6f26ahr 4264 11 and and CC cord-028721-x6f26ahr 4264 12 primary primary JJ cord-028721-x6f26ahr 4264 13 sterility sterility NN cord-028721-x6f26ahr 4264 14 Tail Tail NNP cord-028721-x6f26ahr 4264 15 stump stump NN cord-028721-x6f26ahr 4264 16 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4264 17 : : : cord-028721-x6f26ahr 4264 18 morphogenesis morphogenesis NN cord-028721-x6f26ahr 4264 19 of of IN cord-028721-x6f26ahr 4264 20 the the DT cord-028721-x6f26ahr 4264 21 defect defect NN cord-028721-x6f26ahr 4264 22 . . . cord-028721-x6f26ahr 4265 1 An an DT cord-028721-x6f26ahr 4265 2 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4265 3 study study NN cord-028721-x6f26ahr 4265 4 of of IN cord-028721-x6f26ahr 4265 5 sperm sperm NN cord-028721-x6f26ahr 4265 6 and and CC cord-028721-x6f26ahr 4265 7 testicular testicular JJ cord-028721-x6f26ahr 4265 8 biopsy biopsy NN cord-028721-x6f26ahr 4265 9 Gene Gene NNP cord-028721-x6f26ahr 4265 10 deletions deletion NNS cord-028721-x6f26ahr 4265 11 in in IN cord-028721-x6f26ahr 4265 12 an an DT cord-028721-x6f26ahr 4265 13 infertile infertile JJ cord-028721-x6f26ahr 4265 14 man man NN cord-028721-x6f26ahr 4265 15 with with IN cord-028721-x6f26ahr 4265 16 sperm sperm NN cord-028721-x6f26ahr 4265 17 fi fi NN cord-028721-x6f26ahr 4265 18 brous brous JJ cord-028721-x6f26ahr 4265 19 sheath sheath NN cord-028721-x6f26ahr 4265 20 dysplasia dysplasia NNP cord-028721-x6f26ahr 4265 21 Multi Multi NNP cord-028721-x6f26ahr 4265 22 - - HYPH cord-028721-x6f26ahr 4265 23 tailed tailed JJ cord-028721-x6f26ahr 4265 24 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4265 25 in in IN cord-028721-x6f26ahr 4265 26 a a DT cord-028721-x6f26ahr 4265 27 case case NN cord-028721-x6f26ahr 4265 28 with with IN cord-028721-x6f26ahr 4265 29 asthenospermia asthenospermia NNP cord-028721-x6f26ahr 4265 30 and and CC cord-028721-x6f26ahr 4265 31 teratospermia teratospermia NNP cord-028721-x6f26ahr 4265 32 Sperm Sperm NNP cord-028721-x6f26ahr 4265 33 tail tail NN cord-028721-x6f26ahr 4265 34 agenesis agenesis NN cord-028721-x6f26ahr 4265 35 in in IN cord-028721-x6f26ahr 4265 36 a a DT cord-028721-x6f26ahr 4265 37 case case NN cord-028721-x6f26ahr 4265 38 of of IN cord-028721-x6f26ahr 4265 39 consanguinity consanguinity NN cord-028721-x6f26ahr 4265 40 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4265 41 study study NN cord-028721-x6f26ahr 4265 42 of of IN cord-028721-x6f26ahr 4265 43 the the DT cord-028721-x6f26ahr 4265 44 decapitates decapitates NNP cord-028721-x6f26ahr 4265 45 sperm sperm NN cord-028721-x6f26ahr 4265 46 defect defect NN cord-028721-x6f26ahr 4265 47 in in IN cord-028721-x6f26ahr 4265 48 a a DT cord-028721-x6f26ahr 4265 49 infertile infertile JJ cord-028721-x6f26ahr 4265 50 man man NN cord-028721-x6f26ahr 4265 51 Morphogenesis Morphogenesis NNP cord-028721-x6f26ahr 4265 52 of of IN cord-028721-x6f26ahr 4265 53 the the DT cord-028721-x6f26ahr 4265 54 decapitated decapitate VBN cord-028721-x6f26ahr 4265 55 and and CC cord-028721-x6f26ahr 4265 56 decaudated decaudate VBN cord-028721-x6f26ahr 4265 57 sperm sperm NN cord-028721-x6f26ahr 4265 58 defect defect NN cord-028721-x6f26ahr 4265 59 in in IN cord-028721-x6f26ahr 4265 60 two two CD cord-028721-x6f26ahr 4265 61 brothers brother NNS cord-028721-x6f26ahr 4265 62 Acephalic Acephalic NNP cord-028721-x6f26ahr 4265 63 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4265 64 and and CC cord-028721-x6f26ahr 4265 65 abnormal abnormal JJ cord-028721-x6f26ahr 4265 66 development development NN cord-028721-x6f26ahr 4265 67 of of IN cord-028721-x6f26ahr 4265 68 the the DT cord-028721-x6f26ahr 4265 69 head head NN cord-028721-x6f26ahr 4265 70 - - HYPH cord-028721-x6f26ahr 4265 71 neck neck NN cord-028721-x6f26ahr 4265 72 attachment attachment NN cord-028721-x6f26ahr 4265 73 : : : cord-028721-x6f26ahr 4265 74 a a DT cord-028721-x6f26ahr 4265 75 human human JJ cord-028721-x6f26ahr 4265 76 syndrome syndrome NN cord-028721-x6f26ahr 4265 77 of of IN cord-028721-x6f26ahr 4265 78 genetic genetic JJ cord-028721-x6f26ahr 4265 79 origin origin NN cord-028721-x6f26ahr 4265 80 Sperm sperm NN cord-028721-x6f26ahr 4265 81 structure structure NN cord-028721-x6f26ahr 4265 82 and and CC cord-028721-x6f26ahr 4265 83 its -PRON- PRP$ cord-028721-x6f26ahr 4265 84 relevance relevance NN cord-028721-x6f26ahr 4265 85 to to IN cord-028721-x6f26ahr 4265 86 infertility infertility NN cord-028721-x6f26ahr 4265 87 Decapitated decapitate VBN cord-028721-x6f26ahr 4265 88 and and CC cord-028721-x6f26ahr 4265 89 decaudated decaudate VBN cord-028721-x6f26ahr 4265 90 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 4265 91 in in IN cord-028721-x6f26ahr 4265 92 man man NN cord-028721-x6f26ahr 4265 93 , , , cord-028721-x6f26ahr 4265 94 and and CC cord-028721-x6f26ahr 4265 95 pathogenesis pathogenesis NN cord-028721-x6f26ahr 4265 96 based base VBN cord-028721-x6f26ahr 4265 97 on on IN cord-028721-x6f26ahr 4265 98 the the DT cord-028721-x6f26ahr 4265 99 ultrastructure ultrastructure NN cord-028721-x6f26ahr 4265 100 Assisted assist VBN cord-028721-x6f26ahr 4265 101 reproduction reproduction NN cord-028721-x6f26ahr 4265 102 for for IN cord-028721-x6f26ahr 4265 103 infertile infertile JJ cord-028721-x6f26ahr 4265 104 patients patient NNS cord-028721-x6f26ahr 4265 105 with with IN cord-028721-x6f26ahr 4265 106 9 9 CD cord-028721-x6f26ahr 4265 107 + + SYM cord-028721-x6f26ahr 4265 108 0 0 CD cord-028721-x6f26ahr 4265 109 immotile immotile NN cord-028721-x6f26ahr 4265 110 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4265 111 associated associate VBN cord-028721-x6f26ahr 4265 112 with with IN cord-028721-x6f26ahr 4265 113 autosomal autosomal JJ cord-028721-x6f26ahr 4265 114 dominant dominant JJ cord-028721-x6f26ahr 4265 115 polycystic polycystic JJ cord-028721-x6f26ahr 4265 116 kidney kidney NN cord-028721-x6f26ahr 4265 117 disease disease NN cord-028721-x6f26ahr 4265 118 Spermatozoa Spermatozoa NNP cord-028721-x6f26ahr 4265 119 and and CC cord-028721-x6f26ahr 4265 120 cilia cilium NNS cord-028721-x6f26ahr 4265 121 lacking lack VBG cord-028721-x6f26ahr 4265 122 axoneme axoneme NN cord-028721-x6f26ahr 4265 123 in in IN cord-028721-x6f26ahr 4265 124 an an DT cord-028721-x6f26ahr 4265 125 infertile infertile JJ cord-028721-x6f26ahr 4265 126 man man NN cord-028721-x6f26ahr 4265 127 Lack lack NN cord-028721-x6f26ahr 4265 128 of of IN cord-028721-x6f26ahr 4265 129 dynein dynein JJ cord-028721-x6f26ahr 4265 130 arms arm NNS cord-028721-x6f26ahr 4265 131 in in IN cord-028721-x6f26ahr 4265 132 immotile immotile NNP cord-028721-x6f26ahr 4265 133 human human JJ cord-028721-x6f26ahr 4265 134 spermatozoa spermatozoa NNP cord-028721-x6f26ahr 4265 135 Diagnostic diagnostic JJ cord-028721-x6f26ahr 4265 136 approach approach NN cord-028721-x6f26ahr 4265 137 to to IN cord-028721-x6f26ahr 4265 138 primary primary JJ cord-028721-x6f26ahr 4265 139 ciliary ciliary NN cord-028721-x6f26ahr 4265 140 dyskinesia dyskinesia NN cord-028721-x6f26ahr 4265 141 : : : cord-028721-x6f26ahr 4265 142 a a DT cord-028721-x6f26ahr 4265 143 review review NN cord-028721-x6f26ahr 4265 144 Primary primary JJ cord-028721-x6f26ahr 4265 145 ciliary ciliary NN cord-028721-x6f26ahr 4265 146 dyskinesia dyskinesia NN cord-028721-x6f26ahr 4265 147 : : : cord-028721-x6f26ahr 4266 1 a a DT cord-028721-x6f26ahr 4266 2 review review NN cord-028721-x6f26ahr 4266 3 Anomalies anomaly NNS cord-028721-x6f26ahr 4266 4 of of IN cord-028721-x6f26ahr 4266 5 lateralization lateralization NN cord-028721-x6f26ahr 4266 6 in in IN cord-028721-x6f26ahr 4266 7 man man NN cord-028721-x6f26ahr 4266 8 : : : cord-028721-x6f26ahr 4266 9 a a DT cord-028721-x6f26ahr 4266 10 case case NN cord-028721-x6f26ahr 4266 11 of of IN cord-028721-x6f26ahr 4266 12 total total JJ cord-028721-x6f26ahr 4266 13 situs situs NN cord-028721-x6f26ahr 4266 14 inversus inversus NN cord-028721-x6f26ahr 4266 15 Stiff stiff JJ cord-028721-x6f26ahr 4266 16 - - HYPH cord-028721-x6f26ahr 4266 17 tail tail NN cord-028721-x6f26ahr 4266 18 - - HYPH cord-028721-x6f26ahr 4266 19 oder oder NNP cord-028721-x6f26ahr 4266 20 Mittelstück Mittelstück NNP cord-028721-x6f26ahr 4266 21 - - HYPH cord-028721-x6f26ahr 4266 22 Syndrom Syndrom NNP cord-028721-x6f26ahr 4266 23 Pour Pour NNP cord-028721-x6f26ahr 4266 24 development development NN cord-028721-x6f26ahr 4266 25 of of IN cord-028721-x6f26ahr 4266 26 outer outer JJ cord-028721-x6f26ahr 4266 27 dense dense JJ cord-028721-x6f26ahr 4266 28 fi fi NN cord-028721-x6f26ahr 4266 29 bres bres FW cord-028721-x6f26ahr 4266 30 as as IN cord-028721-x6f26ahr 4266 31 a a DT cord-028721-x6f26ahr 4266 32 mayor mayor NN cord-028721-x6f26ahr 4266 33 cause cause NN cord-028721-x6f26ahr 4266 34 of of IN cord-028721-x6f26ahr 4266 35 tail tail NN cord-028721-x6f26ahr 4266 36 abnormalities abnormality NNS cord-028721-x6f26ahr 4266 37 in in IN cord-028721-x6f26ahr 4266 38 the the DT cord-028721-x6f26ahr 4266 39 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4266 40 of of IN cord-028721-x6f26ahr 4266 41 asthenoteratozoospermic asthenoteratozoospermic JJ cord-028721-x6f26ahr 4266 42 men man NNS cord-028721-x6f26ahr 4266 43 Human human JJ cord-028721-x6f26ahr 4266 44 mtDNA mtdna JJ cord-028721-x6f26ahr 4266 45 haplogroups haplogroup NNS cord-028721-x6f26ahr 4266 46 associated associate VBN cord-028721-x6f26ahr 4266 47 with with IN cord-028721-x6f26ahr 4266 48 high high JJ cord-028721-x6f26ahr 4266 49 or or CC cord-028721-x6f26ahr 4266 50 reduced reduced JJ cord-028721-x6f26ahr 4266 51 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 4266 52 motility motility NN cord-028721-x6f26ahr 4266 53 Male male JJ cord-028721-x6f26ahr 4266 54 infertility infertility NN cord-028721-x6f26ahr 4266 55 and and CC cord-028721-x6f26ahr 4266 56 mitochondrial mitochondrial JJ cord-028721-x6f26ahr 4266 57 DNA DNA NNP cord-028721-x6f26ahr 4266 58 Carcinoma Carcinoma NNP cord-028721-x6f26ahr 4266 59 in in IN cord-028721-x6f26ahr 4266 60 situ situ NN cord-028721-x6f26ahr 4266 61 in in IN cord-028721-x6f26ahr 4266 62 testicular testicular JJ cord-028721-x6f26ahr 4266 63 biopsies biopsy NNS cord-028721-x6f26ahr 4266 64 from from IN cord-028721-x6f26ahr 4266 65 men man NNS cord-028721-x6f26ahr 4266 66 presenting present VBG cord-028721-x6f26ahr 4266 67 with with IN cord-028721-x6f26ahr 4266 68 infertility infertility NN cord-028721-x6f26ahr 4266 69 Carcinoma Carcinoma NNP cord-028721-x6f26ahr 4266 70 in in IN cord-028721-x6f26ahr 4266 71 situ situ NN cord-028721-x6f26ahr 4266 72 of of IN cord-028721-x6f26ahr 4266 73 the the DT cord-028721-x6f26ahr 4266 74 testis testis NN cord-028721-x6f26ahr 4266 75 in in IN cord-028721-x6f26ahr 4266 76 infertile infertile JJ cord-028721-x6f26ahr 4266 77 men man NNS cord-028721-x6f26ahr 4266 78 . . . cord-028721-x6f26ahr 4267 1 A a DT cord-028721-x6f26ahr 4267 2 histological histological JJ cord-028721-x6f26ahr 4267 3 , , , cord-028721-x6f26ahr 4267 4 immunocytochemical immunocytochemical JJ cord-028721-x6f26ahr 4267 5 and and CC cord-028721-x6f26ahr 4267 6 cytophotometric cytophotometric JJ cord-028721-x6f26ahr 4267 7 study study NN cord-028721-x6f26ahr 4267 8 of of IN cord-028721-x6f26ahr 4267 9 DNA DNA NNP cord-028721-x6f26ahr 4267 10 content content NN cord-028721-x6f26ahr 4267 11 Early early JJ cord-028721-x6f26ahr 4267 12 testicular testicular JJ cord-028721-x6f26ahr 4267 13 cancer cancer NN cord-028721-x6f26ahr 4267 14 in in IN cord-028721-x6f26ahr 4267 15 severe severe JJ cord-028721-x6f26ahr 4267 16 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 4267 17 Carcinoma carcinoma NN cord-028721-x6f26ahr 4267 18 - - HYPH cord-028721-x6f26ahr 4267 19 insitu insitu NNS cord-028721-x6f26ahr 4267 20 of of IN cord-028721-x6f26ahr 4267 21 the the DT cord-028721-x6f26ahr 4267 22 testis testis NN cord-028721-x6f26ahr 4267 23 : : : cord-028721-x6f26ahr 4267 24 possible possible JJ cord-028721-x6f26ahr 4267 25 origin origin NN cord-028721-x6f26ahr 4267 26 from from IN cord-028721-x6f26ahr 4267 27 gonocytes gonocyte NNS cord-028721-x6f26ahr 4267 28 and and CC cord-028721-x6f26ahr 4267 29 precursor precursor NN cord-028721-x6f26ahr 4267 30 of of IN cord-028721-x6f26ahr 4267 31 all all DT cord-028721-x6f26ahr 4267 32 types type NNS cord-028721-x6f26ahr 4267 33 of of IN cord-028721-x6f26ahr 4267 34 germ germ NN cord-028721-x6f26ahr 4267 35 cell cell NN cord-028721-x6f26ahr 4267 36 tumours tumour NNS cord-028721-x6f26ahr 4267 37 except except IN cord-028721-x6f26ahr 4267 38 spermatocytoma spermatocytoma NNP cord-028721-x6f26ahr 4267 39 Male male JJ cord-028721-x6f26ahr 4267 40 subfertility subfertility NN cord-028721-x6f26ahr 4267 41 . . . cord-028721-x6f26ahr 4268 1 Continuing continue VBG cord-028721-x6f26ahr 4268 2 diagnostic diagnostic JJ cord-028721-x6f26ahr 4268 3 and and CC cord-028721-x6f26ahr 4268 4 therapeutic therapeutic JJ cord-028721-x6f26ahr 4268 5 measures measure NNS cord-028721-x6f26ahr 4269 1 Testicular testicular JJ cord-028721-x6f26ahr 4269 2 cancer cancer NN cord-028721-x6f26ahr 4269 3 risk risk NN cord-028721-x6f26ahr 4269 4 in in IN cord-028721-x6f26ahr 4269 5 boys boy NNS cord-028721-x6f26ahr 4269 6 with with IN cord-028721-x6f26ahr 4269 7 maldescended maldescended JJ cord-028721-x6f26ahr 4269 8 testis testis NN cord-028721-x6f26ahr 4269 9 : : : cord-028721-x6f26ahr 4269 10 A a DT cord-028721-x6f26ahr 4269 11 cohort cohort NN cord-028721-x6f26ahr 4269 12 study study NN cord-028721-x6f26ahr 4269 13 Seminoma Seminoma NNP cord-028721-x6f26ahr 4269 14 discovered discover VBD cord-028721-x6f26ahr 4269 15 in in IN cord-028721-x6f26ahr 4269 16 two two CD cord-028721-x6f26ahr 4269 17 males male NNS cord-028721-x6f26ahr 4269 18 undergoing undergo VBG cord-028721-x6f26ahr 4269 19 successful successful JJ cord-028721-x6f26ahr 4269 20 testicular testicular JJ cord-028721-x6f26ahr 4269 21 sperm sperm NN cord-028721-x6f26ahr 4269 22 extraction extraction NN cord-028721-x6f26ahr 4269 23 for for IN cord-028721-x6f26ahr 4269 24 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 4269 25 sperm sperm NN cord-028721-x6f26ahr 4269 26 injection injection NN cord-028721-x6f26ahr 4269 27 Screening screen VBG cord-028721-x6f26ahr 4269 28 for for IN cord-028721-x6f26ahr 4269 29 carcinoma carcinoma NN cord-028721-x6f26ahr 4269 30 in in IN cord-028721-x6f26ahr 4269 31 situ situ NN cord-028721-x6f26ahr 4269 32 of of IN cord-028721-x6f26ahr 4269 33 the the DT cord-028721-x6f26ahr 4269 34 contralateral contralateral JJ cord-028721-x6f26ahr 4269 35 testis testis NN cord-028721-x6f26ahr 4269 36 in in IN cord-028721-x6f26ahr 4269 37 patients patient NNS cord-028721-x6f26ahr 4269 38 with with IN cord-028721-x6f26ahr 4269 39 germinal germinal JJ cord-028721-x6f26ahr 4269 40 testicular testicular NNP cord-028721-x6f26ahr 4269 41 cancer cancer NN cord-028721-x6f26ahr 4270 1 The the DT cord-028721-x6f26ahr 4270 2 incidence incidence NN cord-028721-x6f26ahr 4270 3 of of IN cord-028721-x6f26ahr 4270 4 seminoma seminoma NN cord-028721-x6f26ahr 4270 5 and and CC cord-028721-x6f26ahr 4270 6 expression expression NN cord-028721-x6f26ahr 4270 7 of of IN cord-028721-x6f26ahr 4270 8 cell cell NN cord-028721-x6f26ahr 4270 9 adhesion adhesion NN cord-028721-x6f26ahr 4270 10 CD44 CD44 NNP cord-028721-x6f26ahr 4270 11 in in IN cord-028721-x6f26ahr 4270 12 cryptorchid cryptorchid JJ cord-028721-x6f26ahr 4270 13 boys boy NNS cord-028721-x6f26ahr 4270 14 and and CC cord-028721-x6f26ahr 4270 15 infertile infertile JJ cord-028721-x6f26ahr 4270 16 men man NNS cord-028721-x6f26ahr 4271 1 A a DT cord-028721-x6f26ahr 4271 2 novel novel JJ cord-028721-x6f26ahr 4271 3 androgen androgen NN cord-028721-x6f26ahr 4271 4 receptor receptor NN cord-028721-x6f26ahr 4271 5 mutation mutation NN cord-028721-x6f26ahr 4271 6 resulting result VBG cord-028721-x6f26ahr 4271 7 in in IN cord-028721-x6f26ahr 4271 8 complete complete JJ cord-028721-x6f26ahr 4271 9 androgen androgen NN cord-028721-x6f26ahr 4271 10 insensitivity insensitivity NN cord-028721-x6f26ahr 4271 11 syndrome syndrome NN cord-028721-x6f26ahr 4271 12 and and CC cord-028721-x6f26ahr 4271 13 bilateral bilateral JJ cord-028721-x6f26ahr 4271 14 Leydig Leydig NNP cord-028721-x6f26ahr 4271 15 cell cell NN cord-028721-x6f26ahr 4271 16 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4271 17 Leydig Leydig NNP cord-028721-x6f26ahr 4271 18 cell cell NN cord-028721-x6f26ahr 4271 19 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4271 20 mimicking mimic VBG cord-028721-x6f26ahr 4271 21 testicular testicular JJ cord-028721-x6f26ahr 4271 22 neoplasm neoplasm NN cord-028721-x6f26ahr 4271 23 Increased increase VBN cord-028721-x6f26ahr 4271 24 mast mast NN cord-028721-x6f26ahr 4271 25 cells cell NNS cord-028721-x6f26ahr 4271 26 in in IN cord-028721-x6f26ahr 4271 27 the the DT cord-028721-x6f26ahr 4271 28 limiting limit VBG cord-028721-x6f26ahr 4271 29 membrane membrane NN cord-028721-x6f26ahr 4271 30 of of IN cord-028721-x6f26ahr 4271 31 seminiferous seminiferous JJ cord-028721-x6f26ahr 4271 32 tubules tubule NNS cord-028721-x6f26ahr 4271 33 in in IN cord-028721-x6f26ahr 4271 34 the the DT cord-028721-x6f26ahr 4271 35 testes testis NNS cord-028721-x6f26ahr 4271 36 of of IN cord-028721-x6f26ahr 4271 37 patients patient NNS cord-028721-x6f26ahr 4271 38 with with IN cord-028721-x6f26ahr 4271 39 idiopathic idiopathic JJ cord-028721-x6f26ahr 4271 40 infertility infertility NN cord-028721-x6f26ahr 4271 41 Testicular Testicular NNP cord-028721-x6f26ahr 4271 42 mast mast JJ cord-028721-x6f26ahr 4271 43 cell cell NN cord-028721-x6f26ahr 4271 44 heterogeneity heterogeneity NN cord-028721-x6f26ahr 4271 45 in in IN cord-028721-x6f26ahr 4271 46 idiopathic idiopathic JJ cord-028721-x6f26ahr 4271 47 male male JJ cord-028721-x6f26ahr 4271 48 infertility infertility NN cord-028721-x6f26ahr 4271 49 Mast Mast NNP cord-028721-x6f26ahr 4271 50 cells cell NNS cord-028721-x6f26ahr 4271 51 in in IN cord-028721-x6f26ahr 4271 52 testicular testicular JJ cord-028721-x6f26ahr 4271 53 lesions lesion NNS cord-028721-x6f26ahr 4271 54 Ketotifen Ketotifen NNP cord-028721-x6f26ahr 4271 55 improves improve VBZ cord-028721-x6f26ahr 4271 56 sperm sperm NN cord-028721-x6f26ahr 4271 57 motility motility NN cord-028721-x6f26ahr 4271 58 and and CC cord-028721-x6f26ahr 4271 59 sperm sperm NN cord-028721-x6f26ahr 4271 60 morphology morphology NN cord-028721-x6f26ahr 4271 61 in in IN cord-028721-x6f26ahr 4271 62 male male JJ cord-028721-x6f26ahr 4271 63 patients patient NNS cord-028721-x6f26ahr 4271 64 with with IN cord-028721-x6f26ahr 4271 65 leukocytospermia leukocytospermia NN cord-028721-x6f26ahr 4271 66 and and CC cord-028721-x6f26ahr 4271 67 unexplained unexplained JJ cord-028721-x6f26ahr 4271 68 infertility infertility NN cord-028721-x6f26ahr 4272 1 An an DT cord-028721-x6f26ahr 4272 2 attempt attempt NN cord-028721-x6f26ahr 4272 3 to to TO cord-028721-x6f26ahr 4272 4 explain explain VB cord-028721-x6f26ahr 4272 5 occurrence occurrence NN cord-028721-x6f26ahr 4272 6 of of IN cord-028721-x6f26ahr 4272 7 patent patent NN cord-028721-x6f26ahr 4272 8 reproductive reproductive JJ cord-028721-x6f26ahr 4272 9 tract tract NN cord-028721-x6f26ahr 4272 10 in in IN cord-028721-x6f26ahr 4272 11 azoospermic azoospermic NNP cord-028721-x6f26ahr 4272 12 males male NNS cord-028721-x6f26ahr 4272 13 with with IN cord-028721-x6f26ahr 4272 14 tubular tubular JJ cord-028721-x6f26ahr 4272 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4272 16 Quantitative quantitative JJ cord-028721-x6f26ahr 4272 17 analysis analysis NN cord-028721-x6f26ahr 4272 18 of of IN cord-028721-x6f26ahr 4272 19 testicular testicular JJ cord-028721-x6f26ahr 4272 20 biopsy biopsy NN cord-028721-x6f26ahr 4272 21 : : : cord-028721-x6f26ahr 4272 22 determination determination NN cord-028721-x6f26ahr 4272 23 of of IN cord-028721-x6f26ahr 4272 24 partial partial JJ cord-028721-x6f26ahr 4272 25 obstruction obstruction NN cord-028721-x6f26ahr 4272 26 and and CC cord-028721-x6f26ahr 4272 27 prediction prediction NN cord-028721-x6f26ahr 4272 28 of of IN cord-028721-x6f26ahr 4272 29 sperm sperm NN cord-028721-x6f26ahr 4272 30 count count NN cord-028721-x6f26ahr 4272 31 after after IN cord-028721-x6f26ahr 4272 32 surgery surgery NN cord-028721-x6f26ahr 4272 33 for for IN cord-028721-x6f26ahr 4272 34 obstruction obstruction NN cord-028721-x6f26ahr 4272 35 Correlation correlation NN cord-028721-x6f26ahr 4272 36 between between IN cord-028721-x6f26ahr 4272 37 spermatozoon spermatozoon NN cord-028721-x6f26ahr 4272 38 numbers number NNS cord-028721-x6f26ahr 4272 39 in in IN cord-028721-x6f26ahr 4272 40 spermiogram spermiogram NNP cord-028721-x6f26ahr 4272 41 and and CC cord-028721-x6f26ahr 4272 42 seminiferous seminiferous JJ cord-028721-x6f26ahr 4272 43 epithelium epithelium NN cord-028721-x6f26ahr 4272 44 histology histology NN cord-028721-x6f26ahr 4272 45 in in IN cord-028721-x6f26ahr 4272 46 testicular testicular JJ cord-028721-x6f26ahr 4272 47 biopsies biopsy NNS cord-028721-x6f26ahr 4272 48 from from IN cord-028721-x6f26ahr 4272 49 subfertile subfertile JJ cord-028721-x6f26ahr 4272 50 men man NNS cord-028721-x6f26ahr 4272 51 Alpha-1,4-glucosidase Alpha-1,4-glucosidase NNP cord-028721-x6f26ahr 4272 52 activity activity NN cord-028721-x6f26ahr 4272 53 and and CC cord-028721-x6f26ahr 4272 54 the the DT cord-028721-x6f26ahr 4272 55 presence presence NN cord-028721-x6f26ahr 4272 56 of of IN cord-028721-x6f26ahr 4272 57 germinal germinal JJ cord-028721-x6f26ahr 4272 58 epithelium epithelium NN cord-028721-x6f26ahr 4272 59 cells cell NNS cord-028721-x6f26ahr 4272 60 in in IN cord-028721-x6f26ahr 4272 61 the the DT cord-028721-x6f26ahr 4272 62 semen semen NN cord-028721-x6f26ahr 4272 63 for for IN cord-028721-x6f26ahr 4272 64 differential differential JJ cord-028721-x6f26ahr 4272 65 diagnosis diagnosis NN cord-028721-x6f26ahr 4272 66 of of IN cord-028721-x6f26ahr 4272 67 obstructive obstructive JJ cord-028721-x6f26ahr 4272 68 and and CC cord-028721-x6f26ahr 4272 69 nonobstructive nonobstructive JJ cord-028721-x6f26ahr 4272 70 azoospermia azoospermia NN cord-028721-x6f26ahr 4272 71 Ejaculatory Ejaculatory NNP cord-028721-x6f26ahr 4272 72 duct duct NN cord-028721-x6f26ahr 4272 73 obstruction obstruction NN cord-028721-x6f26ahr 4272 74 in in IN cord-028721-x6f26ahr 4272 75 subfertile subfertile NNP cord-028721-x6f26ahr 4272 76 males male NNS cord-028721-x6f26ahr 4272 77 : : : cord-028721-x6f26ahr 4272 78 analysis analysis NN cord-028721-x6f26ahr 4272 79 of of IN cord-028721-x6f26ahr 4272 80 87 87 CD cord-028721-x6f26ahr 4272 81 patients patient NNS cord-028721-x6f26ahr 4272 82 Paratesticular Paratesticular NNP cord-028721-x6f26ahr 4272 83 cysts cyst NNS cord-028721-x6f26ahr 4272 84 with with IN cord-028721-x6f26ahr 4272 85 benign benign JJ cord-028721-x6f26ahr 4272 86 epithelial epithelial JJ cord-028721-x6f26ahr 4272 87 proliferations proliferation NNS cord-028721-x6f26ahr 4272 88 of of IN cord-028721-x6f26ahr 4272 89 wolffi wolffi NNP cord-028721-x6f26ahr 4272 90 an an DT cord-028721-x6f26ahr 4272 91 origin origin NN cord-028721-x6f26ahr 4272 92 Von Von NNP cord-028721-x6f26ahr 4272 93 Hippel Hippel NNP cord-028721-x6f26ahr 4272 94 - - HYPH cord-028721-x6f26ahr 4272 95 Lindau Lindau NNP cord-028721-x6f26ahr 4272 96 disease disease NN cord-028721-x6f26ahr 4272 97 Prevalence prevalence NN cord-028721-x6f26ahr 4272 98 of of IN cord-028721-x6f26ahr 4272 99 epididymal epididymal JJ cord-028721-x6f26ahr 4272 100 , , , cord-028721-x6f26ahr 4272 101 seminal seminal JJ cord-028721-x6f26ahr 4272 102 vesicle vesicle NN cord-028721-x6f26ahr 4272 103 , , , cord-028721-x6f26ahr 4272 104 prostate prostate NN cord-028721-x6f26ahr 4272 105 , , , cord-028721-x6f26ahr 4272 106 and and CC cord-028721-x6f26ahr 4272 107 testicular testicular JJ cord-028721-x6f26ahr 4272 108 cysts cyst NNS cord-028721-x6f26ahr 4272 109 in in IN cord-028721-x6f26ahr 4272 110 autosomal autosomal JJ cord-028721-x6f26ahr 4272 111 dominant dominant JJ cord-028721-x6f26ahr 4272 112 polycystic polycystic JJ cord-028721-x6f26ahr 4272 113 kidney kidney NN cord-028721-x6f26ahr 4272 114 disease disease NN cord-028721-x6f26ahr 4272 115 Congenital congenital JJ cord-028721-x6f26ahr 4272 116 anomalies anomaly NNS cord-028721-x6f26ahr 4272 117 of of IN cord-028721-x6f26ahr 4272 118 the the DT cord-028721-x6f26ahr 4272 119 vas vas NNP cord-028721-x6f26ahr 4272 120 deferens deferen NNS cord-028721-x6f26ahr 4272 121 , , , cord-028721-x6f26ahr 4272 122 epididymis epididymis NN cord-028721-x6f26ahr 4272 123 , , , cord-028721-x6f26ahr 4272 124 and and CC cord-028721-x6f26ahr 4272 125 seminal seminal JJ cord-028721-x6f26ahr 4272 126 vesicles vesicle NNS cord-028721-x6f26ahr 4273 1 Etiologic etiologic NN cord-028721-x6f26ahr 4273 2 factors factor NNS cord-028721-x6f26ahr 4273 3 in in IN cord-028721-x6f26ahr 4273 4 1294 1294 CD cord-028721-x6f26ahr 4273 5 consecutive consecutive JJ cord-028721-x6f26ahr 4273 6 cases case NNS cord-028721-x6f26ahr 4273 7 of of IN cord-028721-x6f26ahr 4273 8 male male JJ cord-028721-x6f26ahr 4273 9 infertility infertility NN cord-028721-x6f26ahr 4273 10 Male male JJ cord-028721-x6f26ahr 4273 11 fertility fertility NN cord-028721-x6f26ahr 4273 12 and and CC cord-028721-x6f26ahr 4273 13 positive positive JJ cord-028721-x6f26ahr 4273 14 chlamydial chlamydial JJ cord-028721-x6f26ahr 4273 15 serology serology NN cord-028721-x6f26ahr 4273 16 . . . cord-028721-x6f26ahr 4274 1 A a DT cord-028721-x6f26ahr 4274 2 study study NN cord-028721-x6f26ahr 4274 3 of of IN cord-028721-x6f26ahr 4274 4 61 61 CD cord-028721-x6f26ahr 4274 5 fertile fertile JJ cord-028721-x6f26ahr 4274 6 and and CC cord-028721-x6f26ahr 4274 7 82 82 CD cord-028721-x6f26ahr 4275 1 subfertile subfertile NNP cord-028721-x6f26ahr 4276 1 men man NNS cord-028721-x6f26ahr 4276 2 Relationship Relationship NNP cord-028721-x6f26ahr 4276 3 of of IN cord-028721-x6f26ahr 4276 4 bacteriologic bacteriologic JJ cord-028721-x6f26ahr 4276 5 characteristics characteristic NNS cord-028721-x6f26ahr 4276 6 to to IN cord-028721-x6f26ahr 4276 7 semen semen NN cord-028721-x6f26ahr 4276 8 indices index NNS cord-028721-x6f26ahr 4276 9 in in IN cord-028721-x6f26ahr 4276 10 men man NNS cord-028721-x6f26ahr 4276 11 attending attend VBG cord-028721-x6f26ahr 4276 12 an an DT cord-028721-x6f26ahr 4276 13 infertility infertility NN cord-028721-x6f26ahr 4276 14 clinic clinic NN cord-028721-x6f26ahr 4276 15 Treatment treatment NN cord-028721-x6f26ahr 4276 16 of of IN cord-028721-x6f26ahr 4276 17 bacterial bacterial JJ cord-028721-x6f26ahr 4276 18 urinary urinary JJ cord-028721-x6f26ahr 4276 19 tract tract NN cord-028721-x6f26ahr 4276 20 infections infection NNS cord-028721-x6f26ahr 4276 21 : : : cord-028721-x6f26ahr 4276 22 presence presence NN cord-028721-x6f26ahr 4276 23 and and CC cord-028721-x6f26ahr 4276 24 future future JJ cord-028721-x6f26ahr 4276 25 Relationship relationship NN cord-028721-x6f26ahr 4276 26 of of IN cord-028721-x6f26ahr 4276 27 azoospermia azoospermia NN cord-028721-x6f26ahr 4276 28 to to IN cord-028721-x6f26ahr 4276 29 inguinal inguinal JJ cord-028721-x6f26ahr 4276 30 surgery surgery NN cord-028721-x6f26ahr 4276 31 Coarse coarse JJ cord-028721-x6f26ahr 4276 32 granular granular JJ cord-028721-x6f26ahr 4276 33 cytoplasmic cytoplasmic JJ cord-028721-x6f26ahr 4276 34 change change NN cord-028721-x6f26ahr 4276 35 of of IN cord-028721-x6f26ahr 4276 36 the the DT cord-028721-x6f26ahr 4276 37 epididymis epididymis NN cord-028721-x6f26ahr 4276 38 . . . cord-028721-x6f26ahr 4277 1 An an DT cord-028721-x6f26ahr 4277 2 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4277 3 and and CC cord-028721-x6f26ahr 4277 4 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4277 5 study study NN cord-028721-x6f26ahr 4277 6 Histology Histology NNP cord-028721-x6f26ahr 4277 7 of of IN cord-028721-x6f26ahr 4277 8 the the DT cord-028721-x6f26ahr 4277 9 epididymis epididymis NN cord-028721-x6f26ahr 4277 10 in in IN cord-028721-x6f26ahr 4277 11 men man NNS cord-028721-x6f26ahr 4277 12 with with IN cord-028721-x6f26ahr 4277 13 obstructive obstructive JJ cord-028721-x6f26ahr 4277 14 infertility infertility NN cord-028721-x6f26ahr 4277 15 Quantitative Quantitative NNP cord-028721-x6f26ahr 4277 16 testicular testicular JJ cord-028721-x6f26ahr 4277 17 biopsy biopsy NN cord-028721-x6f26ahr 4277 18 in in IN cord-028721-x6f26ahr 4277 19 spinal spinal JJ cord-028721-x6f26ahr 4277 20 cord cord NN cord-028721-x6f26ahr 4277 21 injured injure VBN cord-028721-x6f26ahr 4277 22 men man NNS cord-028721-x6f26ahr 4277 23 : : : cord-028721-x6f26ahr 4277 24 comparison comparison NN cord-028721-x6f26ahr 4277 25 to to IN cord-028721-x6f26ahr 4277 26 fertile fertile JJ cord-028721-x6f26ahr 4277 27 controls control NNS cord-028721-x6f26ahr 4278 1 Some some DT cord-028721-x6f26ahr 4278 2 gross gross JJ cord-028721-x6f26ahr 4278 3 observations observation NNS cord-028721-x6f26ahr 4278 4 of of IN cord-028721-x6f26ahr 4278 5 the the DT cord-028721-x6f26ahr 4278 6 epididymides epididymis NNS cord-028721-x6f26ahr 4278 7 following follow VBG cord-028721-x6f26ahr 4278 8 vasectomy vasectomy NN cord-028721-x6f26ahr 4278 9 : : : cord-028721-x6f26ahr 4278 10 a a DT cord-028721-x6f26ahr 4278 11 clinical clinical JJ cord-028721-x6f26ahr 4278 12 study study NN cord-028721-x6f26ahr 4278 13 Chronic Chronic NNP cord-028721-x6f26ahr 4278 14 testicular testicular JJ cord-028721-x6f26ahr 4278 15 pain pain NN cord-028721-x6f26ahr 4278 16 following follow VBG cord-028721-x6f26ahr 4278 17 vasectomy vasectomy NN cord-028721-x6f26ahr 4278 18 Quantitative quantitative JJ cord-028721-x6f26ahr 4278 19 pathologic pathologic JJ cord-028721-x6f26ahr 4278 20 changes change NNS cord-028721-x6f26ahr 4278 21 in in IN cord-028721-x6f26ahr 4278 22 the the DT cord-028721-x6f26ahr 4278 23 human human JJ cord-028721-x6f26ahr 4278 24 testis testis NN cord-028721-x6f26ahr 4278 25 after after IN cord-028721-x6f26ahr 4278 26 vasectomy vasectomy NN cord-028721-x6f26ahr 4278 27 . . . cord-028721-x6f26ahr 4279 1 A a DT cord-028721-x6f26ahr 4279 2 controlled control VBN cord-028721-x6f26ahr 4279 3 study study NN cord-028721-x6f26ahr 4279 4 Consequences consequence NNS cord-028721-x6f26ahr 4279 5 of of IN cord-028721-x6f26ahr 4279 6 vasectomy vasectomy NN cord-028721-x6f26ahr 4279 7 : : : cord-028721-x6f26ahr 4279 8 an an DT cord-028721-x6f26ahr 4279 9 immunological immunological JJ cord-028721-x6f26ahr 4279 10 and and CC cord-028721-x6f26ahr 4279 11 histological histological JJ cord-028721-x6f26ahr 4279 12 study study NN cord-028721-x6f26ahr 4279 13 related relate VBN cord-028721-x6f26ahr 4279 14 to to IN cord-028721-x6f26ahr 4279 15 subsequent subsequent JJ cord-028721-x6f26ahr 4279 16 fertility fertility NN cord-028721-x6f26ahr 4280 1 The the DT cord-028721-x6f26ahr 4280 2 status status NN cord-028721-x6f26ahr 4280 3 of of IN cord-028721-x6f26ahr 4280 4 vasectomy vasectomy NN cord-028721-x6f26ahr 4280 5 reversals reversal NNS cord-028721-x6f26ahr 4281 1 A a DT cord-028721-x6f26ahr 4281 2 fi fi NN cord-028721-x6f26ahr 4281 3 fteen fteen NN cord-028721-x6f26ahr 4281 4 - - HYPH cord-028721-x6f26ahr 4281 5 year year NN cord-028721-x6f26ahr 4281 6 study study NN cord-028721-x6f26ahr 4281 7 of of IN cord-028721-x6f26ahr 4281 8 alterations alteration NNS cord-028721-x6f26ahr 4281 9 in in IN cord-028721-x6f26ahr 4281 10 semen semen NN cord-028721-x6f26ahr 4281 11 quality quality NN cord-028721-x6f26ahr 4281 12 occurring occur VBG cord-028721-x6f26ahr 4281 13 after after IN cord-028721-x6f26ahr 4281 14 vasectomy vasectomy NN cord-028721-x6f26ahr 4281 15 reversal reversal NN cord-028721-x6f26ahr 4281 16 Surgical surgical JJ cord-028721-x6f26ahr 4281 17 treatment treatment NN cord-028721-x6f26ahr 4281 18 of of IN cord-028721-x6f26ahr 4281 19 male male JJ cord-028721-x6f26ahr 4281 20 infertility infertility NN cord-028721-x6f26ahr 4281 21 Young Young NNP cord-028721-x6f26ahr 4281 22 's 's POS cord-028721-x6f26ahr 4281 23 syndrome syndrome NN cord-028721-x6f26ahr 4281 24 : : : cord-028721-x6f26ahr 4282 1 obstructive obstructive JJ cord-028721-x6f26ahr 4282 2 azoospermia azoospermia NN cord-028721-x6f26ahr 4282 3 and and CC cord-028721-x6f26ahr 4282 4 chronic chronic JJ cord-028721-x6f26ahr 4282 5 sinopulmonary sinopulmonary JJ cord-028721-x6f26ahr 4282 6 infections infection NNS cord-028721-x6f26ahr 4282 7 Respiratory respiratory JJ cord-028721-x6f26ahr 4282 8 tract tract NN cord-028721-x6f26ahr 4282 9 disease disease NN cord-028721-x6f26ahr 4282 10 and and CC cord-028721-x6f26ahr 4282 11 obstructive obstructive JJ cord-028721-x6f26ahr 4282 12 azoospermia azoospermia NN cord-028721-x6f26ahr 4282 13 Obstructive obstructive JJ cord-028721-x6f26ahr 4282 14 azoospermia azoospermia NN cord-028721-x6f26ahr 4282 15 : : : cord-028721-x6f26ahr 4282 16 respiratory respiratory JJ cord-028721-x6f26ahr 4282 17 function function NN cord-028721-x6f26ahr 4282 18 tests test NNS cord-028721-x6f26ahr 4282 19 , , , cord-028721-x6f26ahr 4282 20 electron electron NN cord-028721-x6f26ahr 4282 21 microscopy microscopy NNS cord-028721-x6f26ahr 4282 22 and and CC cord-028721-x6f26ahr 4282 23 the the DT cord-028721-x6f26ahr 4282 24 results result NNS cord-028721-x6f26ahr 4282 25 of of IN cord-028721-x6f26ahr 4282 26 surgery surgery NN cord-028721-x6f26ahr 4282 27 Varicose varicose NN cord-028721-x6f26ahr 4282 28 axon axon NN cord-028721-x6f26ahr 4282 29 bearing bear VBG cord-028721-x6f26ahr 4282 30 ' ' `` cord-028721-x6f26ahr 4282 31 synaptic synaptic JJ cord-028721-x6f26ahr 4282 32 ' ' '' cord-028721-x6f26ahr 4282 33 vesicles vesicle NNS cord-028721-x6f26ahr 4282 34 on on IN cord-028721-x6f26ahr 4282 35 the the DT cord-028721-x6f26ahr 4282 36 basal basal NN cord-028721-x6f26ahr 4282 37 lamina lamina NN cord-028721-x6f26ahr 4282 38 of of IN cord-028721-x6f26ahr 4282 39 the the DT cord-028721-x6f26ahr 4282 40 human human JJ cord-028721-x6f26ahr 4282 41 seminiferous seminiferous JJ cord-028721-x6f26ahr 4282 42 tubules tubule NNS cord-028721-x6f26ahr 4282 43 Oxytocin Oxytocin NNP cord-028721-x6f26ahr 4282 44 mediates mediate VBZ cord-028721-x6f26ahr 4282 45 the the DT cord-028721-x6f26ahr 4282 46 estrogendependent estrogendependent NN cord-028721-x6f26ahr 4282 47 contractile contractile JJ cord-028721-x6f26ahr 4282 48 activity activity NN cord-028721-x6f26ahr 4282 49 of of IN cord-028721-x6f26ahr 4282 50 endothelin-1 endothelin-1 NNP cord-028721-x6f26ahr 4282 51 in in IN cord-028721-x6f26ahr 4282 52 human human JJ cord-028721-x6f26ahr 4282 53 and and CC cord-028721-x6f26ahr 4282 54 rabbit rabbit NN cord-028721-x6f26ahr 4282 55 epididymis epididymis NN cord-028721-x6f26ahr 4282 56 Comparison comparison NN cord-028721-x6f26ahr 4282 57 of of IN cord-028721-x6f26ahr 4282 58 the the DT cord-028721-x6f26ahr 4282 59 effectiveness effectiveness NN cord-028721-x6f26ahr 4282 60 of of IN cord-028721-x6f26ahr 4282 61 placebo placebo NN cord-028721-x6f26ahr 4282 62 and and CC cord-028721-x6f26ahr 4282 63 alpha alpha NN cord-028721-x6f26ahr 4282 64 - - HYPH cord-028721-x6f26ahr 4282 65 blocker blocker NN cord-028721-x6f26ahr 4282 66 therapy therapy NN cord-028721-x6f26ahr 4282 67 for for IN cord-028721-x6f26ahr 4282 68 the the DT cord-028721-x6f26ahr 4282 69 treatment treatment NN cord-028721-x6f26ahr 4282 70 of of IN cord-028721-x6f26ahr 4282 71 idiopathic idiopathic JJ cord-028721-x6f26ahr 4282 72 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 4282 73 Screening screening NN cord-028721-x6f26ahr 4282 74 for for IN cord-028721-x6f26ahr 4282 75 abnormalities abnormality NNS cord-028721-x6f26ahr 4282 76 of of IN cord-028721-x6f26ahr 4282 77 chromosomes chromosome NNS cord-028721-x6f26ahr 4282 78 X X NNP cord-028721-x6f26ahr 4282 79 , , , cord-028721-x6f26ahr 4282 80 Y Y NNP cord-028721-x6f26ahr 4282 81 , , , cord-028721-x6f26ahr 4282 82 and and CC cord-028721-x6f26ahr 4282 83 18 18 CD cord-028721-x6f26ahr 4282 84 and and CC cord-028721-x6f26ahr 4282 85 for for IN cord-028721-x6f26ahr 4282 86 diploidy diploidy NNP cord-028721-x6f26ahr 4282 87 in in IN cord-028721-x6f26ahr 4282 88 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4282 89 from from IN cord-028721-x6f26ahr 4282 90 infertile infertile JJ cord-028721-x6f26ahr 4282 91 men man NNS cord-028721-x6f26ahr 4282 92 participating participate VBG cord-028721-x6f26ahr 4282 93 in in IN cord-028721-x6f26ahr 4282 94 an an DT cord-028721-x6f26ahr 4282 95 vitro vitro FW cord-028721-x6f26ahr 4282 96 fertilization fertilization NN cord-028721-x6f26ahr 4282 97 - - HYPH cord-028721-x6f26ahr 4282 98 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 4282 99 sperm sperm NN cord-028721-x6f26ahr 4282 100 injection injection NN cord-028721-x6f26ahr 4282 101 program program NN cord-028721-x6f26ahr 4282 102 Cytogenetic Cytogenetic NNP cord-028721-x6f26ahr 4282 103 study study NN cord-028721-x6f26ahr 4282 104 of of IN cord-028721-x6f26ahr 4282 105 435 435 CD cord-028721-x6f26ahr 4282 106 subfertile subfertile NN cord-028721-x6f26ahr 4282 107 men man NNS cord-028721-x6f26ahr 4282 108 : : : cord-028721-x6f26ahr 4282 109 incidence incidence NN cord-028721-x6f26ahr 4282 110 and and CC cord-028721-x6f26ahr 4282 111 clinical clinical JJ cord-028721-x6f26ahr 4282 112 features feature NNS cord-028721-x6f26ahr 4282 113 Syndrome Syndrome NNP cord-028721-x6f26ahr 4282 114 characterized characterize VBN cord-028721-x6f26ahr 4282 115 by by IN cord-028721-x6f26ahr 4282 116 gynecomastia gynecomastia NN cord-028721-x6f26ahr 4282 117 , , , cord-028721-x6f26ahr 4282 118 aspermatogenesis aspermatogenesis NN cord-028721-x6f26ahr 4282 119 without without IN cord-028721-x6f26ahr 4282 120 aleydigism aleydigism NN cord-028721-x6f26ahr 4282 121 and and CC cord-028721-x6f26ahr 4282 122 increased increase VBN cord-028721-x6f26ahr 4282 123 excretion excretion NN cord-028721-x6f26ahr 4282 124 of of IN cord-028721-x6f26ahr 4282 125 follicle follicle NN cord-028721-x6f26ahr 4282 126 - - HYPH cord-028721-x6f26ahr 4282 127 stimulating stimulate VBG cord-028721-x6f26ahr 4282 128 hormone hormone NN cord-028721-x6f26ahr 4282 129 Infertility Infertility NNP cord-028721-x6f26ahr 4282 130 in in IN cord-028721-x6f26ahr 4282 131 the the DT cord-028721-x6f26ahr 4282 132 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 133 syndrome syndrome NN cord-028721-x6f26ahr 4282 134 Control Control NNP cord-028721-x6f26ahr 4282 135 of of IN cord-028721-x6f26ahr 4282 136 meiotic meiotic JJ cord-028721-x6f26ahr 4282 137 process process NN cord-028721-x6f26ahr 4282 138 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 139 syndrome syndrome NN cord-028721-x6f26ahr 4282 140 Endocrine endocrine JJ cord-028721-x6f26ahr 4282 141 features feature NNS cord-028721-x6f26ahr 4282 142 of of IN cord-028721-x6f26ahr 4282 143 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 144 's 's POS cord-028721-x6f26ahr 4282 145 syndrome syndrome NN cord-028721-x6f26ahr 4282 146 Clinical clinical JJ cord-028721-x6f26ahr 4282 147 and and CC cord-028721-x6f26ahr 4282 148 diagnostic diagnostic JJ cord-028721-x6f26ahr 4282 149 features feature NNS cord-028721-x6f26ahr 4282 150 of of IN cord-028721-x6f26ahr 4282 151 patients patient NNS cord-028721-x6f26ahr 4282 152 with with IN cord-028721-x6f26ahr 4282 153 suspected suspect VBN cord-028721-x6f26ahr 4282 154 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 155 syndrome syndrome NN cord-028721-x6f26ahr 4282 156 Clinical clinical JJ cord-028721-x6f26ahr 4282 157 and and CC cord-028721-x6f26ahr 4282 158 therapeutic therapeutic JJ cord-028721-x6f26ahr 4282 159 experiences experience NNS cord-028721-x6f26ahr 4282 160 with with IN cord-028721-x6f26ahr 4282 161 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 162 's 's POS cord-028721-x6f26ahr 4282 163 syndrome syndrome NN cord-028721-x6f26ahr 4282 164 Brain Brain NNP cord-028721-x6f26ahr 4282 165 morphology morphology NN cord-028721-x6f26ahr 4282 166 in in IN cord-028721-x6f26ahr 4282 167 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4282 168 syndrome syndrome NN cord-028721-x6f26ahr 4282 169 : : : cord-028721-x6f26ahr 4282 170 extra extra JJ cord-028721-x6f26ahr 4282 171 X x NN cord-028721-x6f26ahr 4282 172 chromosome chromosome NN cord-028721-x6f26ahr 4282 173 and and CC cord-028721-x6f26ahr 4282 174 testosterone testosterone NN cord-028721-x6f26ahr 4282 175 supplementation supplementation NN cord-028721-x6f26ahr 4283 1 Their -PRON- PRP$ cord-028721-x6f26ahr 4283 2 fi fi NN cord-028721-x6f26ahr 4283 3 ne ne NNP cord-028721-x6f26ahr 4283 4 structure structure NN cord-028721-x6f26ahr 4283 5 in in IN cord-028721-x6f26ahr 4283 6 three three CD cord-028721-x6f26ahr 4283 7 cases case NNS cord-028721-x6f26ahr 4283 8 of of IN cord-028721-x6f26ahr 4283 9 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4283 10 's 's POS cord-028721-x6f26ahr 4283 11 syndrome syndrome NN cord-028721-x6f26ahr 4283 12 Dimorphism dimorphism NN cord-028721-x6f26ahr 4283 13 in in IN cord-028721-x6f26ahr 4283 14 sex sex NN cord-028721-x6f26ahr 4283 15 chromatin chromatin NN cord-028721-x6f26ahr 4283 16 pattern pattern NN cord-028721-x6f26ahr 4283 17 of of IN cord-028721-x6f26ahr 4283 18 Sertoli Sertoli NNP cord-028721-x6f26ahr 4283 19 cells cell NNS cord-028721-x6f26ahr 4283 20 in in IN cord-028721-x6f26ahr 4283 21 adults adult NNS cord-028721-x6f26ahr 4283 22 with with IN cord-028721-x6f26ahr 4283 23 Klinefelter'ssyndrome Klinefelter'ssyndrome NNP cord-028721-x6f26ahr 4283 24 : : : cord-028721-x6f26ahr 4283 25 correlation correlation NN cord-028721-x6f26ahr 4283 26 with with IN cord-028721-x6f26ahr 4283 27 two two CD cord-028721-x6f26ahr 4283 28 types type NNS cord-028721-x6f26ahr 4283 29 of of IN cord-028721-x6f26ahr 4283 30 ' ' `` cord-028721-x6f26ahr 4283 31 Sertoli sertoli JJ cord-028721-x6f26ahr 4283 32 - - HYPH cord-028721-x6f26ahr 4283 33 cell cell NN cord-028721-x6f26ahr 4283 34 - - HYPH cord-028721-x6f26ahr 4283 35 only only RB cord-028721-x6f26ahr 4283 36 ' ' '' cord-028721-x6f26ahr 4283 37 tubes tube NNS cord-028721-x6f26ahr 4283 38 Leydig Leydig NNP cord-028721-x6f26ahr 4283 39 cell cell NN cord-028721-x6f26ahr 4283 40 counts count VBZ cord-028721-x6f26ahr 4283 41 in in IN cord-028721-x6f26ahr 4283 42 chromatin chromatin NN cord-028721-x6f26ahr 4283 43 - - HYPH cord-028721-x6f26ahr 4283 44 positive positive JJ cord-028721-x6f26ahr 4283 45 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4283 46 's 's POS cord-028721-x6f26ahr 4283 47 syndrome syndrome NN cord-028721-x6f26ahr 4283 48 Quantitative quantitative JJ cord-028721-x6f26ahr 4283 49 and and CC cord-028721-x6f26ahr 4283 50 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4283 51 study study NN cord-028721-x6f26ahr 4283 52 of of IN cord-028721-x6f26ahr 4283 53 Leydig Leydig NNP cord-028721-x6f26ahr 4283 54 cells cell NNS cord-028721-x6f26ahr 4283 55 in in IN cord-028721-x6f26ahr 4283 56 Klinefelter'ssyndrome Klinefelter'ssyndrome NNP cord-028721-x6f26ahr 4283 57 Etude Etude NNP cord-028721-x6f26ahr 4283 58 en en FW cord-028721-x6f26ahr 4283 59 microscopie microscopie NNP cord-028721-x6f26ahr 4283 60 électronique électronique NNP cord-028721-x6f26ahr 4284 1 de de NNP cord-028721-x6f26ahr 4284 2 References References NNP cord-028721-x6f26ahr 4284 3 la la NNP cord-028721-x6f26ahr 4284 4 cellule cellule NNP cord-028721-x6f26ahr 4284 5 de de FW cord-028721-x6f26ahr 4284 6 Leydig Leydig NNP cord-028721-x6f26ahr 4284 7 dans dans FW cord-028721-x6f26ahr 4284 8 la la FW cord-028721-x6f26ahr 4284 9 maladie maladie FW cord-028721-x6f26ahr 4284 10 de de FW cord-028721-x6f26ahr 4284 11 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4285 1 en en IN cord-028721-x6f26ahr 4286 1 périodes périodes NNP cord-028721-x6f26ahr 4286 2 pre pre NNP cord-028721-x6f26ahr 4286 3 , , , cord-028721-x6f26ahr 4286 4 per per FW cord-028721-x6f26ahr 4286 5 et et FW cord-028721-x6f26ahr 4286 6 postpubertaires postpubertaires NNP cord-028721-x6f26ahr 4286 7 Testicular Testicular NNP cord-028721-x6f26ahr 4286 8 function function NN cord-028721-x6f26ahr 4286 9 in in IN cord-028721-x6f26ahr 4286 10 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 11 's 's POS cord-028721-x6f26ahr 4286 12 syndrome syndrome NN cord-028721-x6f26ahr 4286 13 Testosterone testosterone NN cord-028721-x6f26ahr 4286 14 and and CC cord-028721-x6f26ahr 4286 15 δ4 δ4 NNS cord-028721-x6f26ahr 4286 16 androstenedione androstenedione NN cord-028721-x6f26ahr 4286 17 in in IN cord-028721-x6f26ahr 4286 18 the the DT cord-028721-x6f26ahr 4286 19 saliva saliva NN cord-028721-x6f26ahr 4286 20 of of IN cord-028721-x6f26ahr 4286 21 patients patient NNS cord-028721-x6f26ahr 4286 22 with with IN cord-028721-x6f26ahr 4286 23 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 24 's 's POS cord-028721-x6f26ahr 4286 25 syndrome syndrome NN cord-028721-x6f26ahr 4286 26 Fine fine JJ cord-028721-x6f26ahr 4286 27 structure structure NN cord-028721-x6f26ahr 4286 28 of of IN cord-028721-x6f26ahr 4286 29 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4286 30 in in IN cord-028721-x6f26ahr 4286 31 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 32 's 's POS cord-028721-x6f26ahr 4286 33 syndrome syndrome NN cord-028721-x6f26ahr 4286 34 Spermatogenesis Spermatogenesis NNP cord-028721-x6f26ahr 4286 35 in in IN cord-028721-x6f26ahr 4286 36 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 37 's 's POS cord-028721-x6f26ahr 4286 38 syndrome syndrome NN cord-028721-x6f26ahr 4286 39 PDG PDG NNP cord-028721-x6f26ahr 4286 40 in in IN cord-028721-x6f26ahr 4286 41 47,XXY 47,xxy JJ cord-028721-x6f26ahr 4286 42 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 43 's 's POS cord-028721-x6f26ahr 4286 44 syndrome syndrome NN cord-028721-x6f26ahr 4286 45 patients patient NNS cord-028721-x6f26ahr 4286 46 Risk Risk NNP cord-028721-x6f26ahr 4286 47 of of IN cord-028721-x6f26ahr 4286 48 trisomy trisomy NN cord-028721-x6f26ahr 4286 49 21 21 CD cord-028721-x6f26ahr 4286 50 in in IN cord-028721-x6f26ahr 4286 51 offspring offspring NN cord-028721-x6f26ahr 4286 52 of of IN cord-028721-x6f26ahr 4286 53 patients patient NNS cord-028721-x6f26ahr 4286 54 with with IN cord-028721-x6f26ahr 4286 55 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4286 56 's 's POS cord-028721-x6f26ahr 4286 57 syndrome syndrome NN cord-028721-x6f26ahr 4287 1 A a DT cord-028721-x6f26ahr 4287 2 new new JJ cord-028721-x6f26ahr 4287 3 chromosome chromosome NN cord-028721-x6f26ahr 4287 4 constitution constitution NN cord-028721-x6f26ahr 4287 5 in in IN cord-028721-x6f26ahr 4287 6 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4287 7 's 's POS cord-028721-x6f26ahr 4287 8 syndrome syndrome NN cord-028721-x6f26ahr 4288 1 A a DT cord-028721-x6f26ahr 4288 2 male male NN cord-028721-x6f26ahr 4288 3 with with IN cord-028721-x6f26ahr 4288 4 XXYY xxyy NN cord-028721-x6f26ahr 4288 5 chromosomes chromosome NNS cord-028721-x6f26ahr 4288 6 Do do VBP cord-028721-x6f26ahr 4288 7 the the DT cord-028721-x6f26ahr 4288 8 48 48 CD cord-028721-x6f26ahr 4288 9 XXYY XXYY NNP cord-028721-x6f26ahr 4288 10 males male NNS cord-028721-x6f26ahr 4288 11 have have VBP cord-028721-x6f26ahr 4288 12 a a DT cord-028721-x6f26ahr 4288 13 characteristic characteristic JJ cord-028721-x6f26ahr 4288 14 phenotype phenotype NN cord-028721-x6f26ahr 4288 15 ? ? . cord-028721-x6f26ahr 4289 1 Genetics genetic NNS cord-028721-x6f26ahr 4289 2 and and CC cord-028721-x6f26ahr 4289 3 endocrine endocrine JJ cord-028721-x6f26ahr 4289 4 fi fi NN cord-028721-x6f26ahr 4289 5 ndings nding NNS cord-028721-x6f26ahr 4289 6 in in IN cord-028721-x6f26ahr 4289 7 a a DT cord-028721-x6f26ahr 4289 8 48 48 CD cord-028721-x6f26ahr 4289 9 XXYY XXYY NNP cord-028721-x6f26ahr 4289 10 male male NN cord-028721-x6f26ahr 4289 11 Dermatoglyphics dermatoglyphic NNS cord-028721-x6f26ahr 4289 12 associated associate VBN cord-028721-x6f26ahr 4289 13 with with IN cord-028721-x6f26ahr 4289 14 the the DT cord-028721-x6f26ahr 4289 15 XXYY XXYY NNP cord-028721-x6f26ahr 4289 16 chromosome chromosome NN cord-028721-x6f26ahr 4289 17 complement complement VBP cord-028721-x6f26ahr 4289 18 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 4289 19 of of IN cord-028721-x6f26ahr 4289 20 Leydig Leydig NNP cord-028721-x6f26ahr 4289 21 cells cell NNS cord-028721-x6f26ahr 4289 22 in in IN cord-028721-x6f26ahr 4289 23 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4289 24 's 's POS cord-028721-x6f26ahr 4289 25 syndrome syndrome NN cord-028721-x6f26ahr 4289 26 with with IN cord-028721-x6f26ahr 4289 27 48 48 CD cord-028721-x6f26ahr 4289 28 XXYY XXYY NNP cord-028721-x6f26ahr 4289 29 karyotype karyotype NN cord-028721-x6f26ahr 4289 30 Primary primary JJ cord-028721-x6f26ahr 4289 31 amentia amentia NN cord-028721-x6f26ahr 4289 32 and and CC cord-028721-x6f26ahr 4289 33 microorchidism microorchidism NN cord-028721-x6f26ahr 4289 34 associated associate VBN cord-028721-x6f26ahr 4289 35 with with IN cord-028721-x6f26ahr 4289 36 an an DT cord-028721-x6f26ahr 4289 37 XXXY XXXY NNP cord-028721-x6f26ahr 4289 38 sex sex NN cord-028721-x6f26ahr 4289 39 - - HYPH cord-028721-x6f26ahr 4289 40 chromosome chromosome NN cord-028721-x6f26ahr 4289 41 constitution constitution NN cord-028721-x6f26ahr 4289 42 49,XXXXY 49,xxxxy CD cord-028721-x6f26ahr 4289 43 syndrome syndrome NN cord-028721-x6f26ahr 4289 44 with with IN cord-028721-x6f26ahr 4289 45 diabetes diabetes NN cord-028721-x6f26ahr 4289 46 mellitus mellitus NN cord-028721-x6f26ahr 4290 1 A a DT cord-028721-x6f26ahr 4290 2 child child NN cord-028721-x6f26ahr 4290 3 with with IN cord-028721-x6f26ahr 4290 4 49 49 CD cord-028721-x6f26ahr 4290 5 chromosomes chromosome NNS cord-028721-x6f26ahr 4290 6 Carcinoma Carcinoma NNP cord-028721-x6f26ahr 4290 7 of of IN cord-028721-x6f26ahr 4290 8 the the DT cord-028721-x6f26ahr 4290 9 male male JJ cord-028721-x6f26ahr 4290 10 breast breast NN cord-028721-x6f26ahr 4290 11 in in IN cord-028721-x6f26ahr 4290 12 association association NN cord-028721-x6f26ahr 4290 13 with with IN cord-028721-x6f26ahr 4290 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 15 's 's POS cord-028721-x6f26ahr 4290 16 syndrome syndrome NN cord-028721-x6f26ahr 4290 17 Male male JJ cord-028721-x6f26ahr 4290 18 breast breast NN cord-028721-x6f26ahr 4290 19 cancer cancer NN cord-028721-x6f26ahr 4290 20 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 21 's 's POS cord-028721-x6f26ahr 4290 22 syndrome syndrome NN cord-028721-x6f26ahr 4290 23 and and CC cord-028721-x6f26ahr 4290 24 breast breast NN cord-028721-x6f26ahr 4290 25 cancer cancer NN cord-028721-x6f26ahr 4290 26 Seminoma Seminoma NNP cord-028721-x6f26ahr 4290 27 in in IN cord-028721-x6f26ahr 4290 28 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 29 's 's POS cord-028721-x6f26ahr 4290 30 syndrome syndrome NN cord-028721-x6f26ahr 4290 31 with with IN cord-028721-x6f26ahr 4290 32 47 47 CD cord-028721-x6f26ahr 4290 33 XXY XXY NNP cord-028721-x6f26ahr 4290 34 , , , cord-028721-x6f26ahr 4290 35 15s+ 15s+ CD cord-028721-x6f26ahr 4290 36 karyotype karyotype NNP cord-028721-x6f26ahr 4290 37 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 38 's 's POS cord-028721-x6f26ahr 4290 39 syndrome syndrome NN cord-028721-x6f26ahr 4290 40 and and CC cord-028721-x6f26ahr 4290 41 mediastinal mediastinal JJ cord-028721-x6f26ahr 4290 42 teratoma teratoma NN cord-028721-x6f26ahr 4290 43 Extragonadal extragonadal JJ cord-028721-x6f26ahr 4290 44 germ germ NN cord-028721-x6f26ahr 4290 45 cell cell NN cord-028721-x6f26ahr 4290 46 tumor tumor NN cord-028721-x6f26ahr 4290 47 in in IN cord-028721-x6f26ahr 4290 48 the the DT cord-028721-x6f26ahr 4290 49 retrovesical retrovesical JJ cord-028721-x6f26ahr 4290 50 region region NN cord-028721-x6f26ahr 4290 51 associated associate VBN cord-028721-x6f26ahr 4290 52 with with IN cord-028721-x6f26ahr 4290 53 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 54 's 's POS cord-028721-x6f26ahr 4290 55 syndrome syndrome NN cord-028721-x6f26ahr 4290 56 : : : cord-028721-x6f26ahr 4290 57 A a DT cord-028721-x6f26ahr 4290 58 case case NN cord-028721-x6f26ahr 4290 59 report report NN cord-028721-x6f26ahr 4290 60 and and CC cord-028721-x6f26ahr 4290 61 review review NN cord-028721-x6f26ahr 4290 62 of of IN cord-028721-x6f26ahr 4290 63 literature literature NN cord-028721-x6f26ahr 4290 64 Primary primary JJ cord-028721-x6f26ahr 4290 65 mediastinal mediastinal JJ cord-028721-x6f26ahr 4290 66 embryonal embryonal JJ cord-028721-x6f26ahr 4290 67 carcinoma carcinoma NN cord-028721-x6f26ahr 4290 68 in in IN cord-028721-x6f26ahr 4290 69 association association NN cord-028721-x6f26ahr 4290 70 with with IN cord-028721-x6f26ahr 4290 71 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4290 72 's 's POS cord-028721-x6f26ahr 4290 73 syndrome syndrome NN cord-028721-x6f26ahr 4291 1 The the DT cord-028721-x6f26ahr 4291 2 malignant malignant JJ cord-028721-x6f26ahr 4291 3 potential potential NN cord-028721-x6f26ahr 4291 4 of of IN cord-028721-x6f26ahr 4291 5 the the DT cord-028721-x6f26ahr 4291 6 dysgenetic dysgenetic JJ cord-028721-x6f26ahr 4291 7 germ germ NN cord-028721-x6f26ahr 4291 8 cell cell NN cord-028721-x6f26ahr 4291 9 in in IN cord-028721-x6f26ahr 4291 10 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4291 11 's 's POS cord-028721-x6f26ahr 4291 12 syndrome syndrome NN cord-028721-x6f26ahr 4291 13 Simian simian JJ cord-028721-x6f26ahr 4291 14 papovavirus papovavirus NN cord-028721-x6f26ahr 4292 1 40 40 CD cord-028721-x6f26ahr 4292 2 transformation transformation NN cord-028721-x6f26ahr 4292 3 of of IN cord-028721-x6f26ahr 4292 4 cells cell NNS cord-028721-x6f26ahr 4292 5 from from IN cord-028721-x6f26ahr 4292 6 cancer cancer NN cord-028721-x6f26ahr 4292 7 patient patient NN cord-028721-x6f26ahr 4292 8 with with IN cord-028721-x6f26ahr 4292 9 XY XY NNP cord-028721-x6f26ahr 4292 10 / / SYM cord-028721-x6f26ahr 4292 11 XXY XXY NNP cord-028721-x6f26ahr 4292 12 mosaic mosaic NN cord-028721-x6f26ahr 4292 13 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4292 14 's 's POS cord-028721-x6f26ahr 4292 15 syndrome syndrome NN cord-028721-x6f26ahr 4293 1 Isolated isolated JJ cord-028721-x6f26ahr 4293 2 primary primary JJ cord-028721-x6f26ahr 4293 3 aldosteronism aldosteronism NN cord-028721-x6f26ahr 4293 4 in in IN cord-028721-x6f26ahr 4293 5 a a DT cord-028721-x6f26ahr 4293 6 patient patient NN cord-028721-x6f26ahr 4293 7 with with IN cord-028721-x6f26ahr 4293 8 adrenal adrenal JJ cord-028721-x6f26ahr 4293 9 carcinoma carcinoma NN cord-028721-x6f26ahr 4293 10 and and CC cord-028721-x6f26ahr 4293 11 XY XY NNP cord-028721-x6f26ahr 4293 12 / / SYM cord-028721-x6f26ahr 4293 13 XXY XXY NNP cord-028721-x6f26ahr 4293 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4293 15 's 's POS cord-028721-x6f26ahr 4293 16 syndrome syndrome NN cord-028721-x6f26ahr 4293 17 Acute Acute NNP cord-028721-x6f26ahr 4293 18 leukemia leukemia NN cord-028721-x6f26ahr 4293 19 following follow VBG cord-028721-x6f26ahr 4293 20 a a DT cord-028721-x6f26ahr 4293 21 malignant malignant JJ cord-028721-x6f26ahr 4293 22 teratoma teratoma NN cord-028721-x6f26ahr 4293 23 in in IN cord-028721-x6f26ahr 4293 24 a a DT cord-028721-x6f26ahr 4293 25 child child NN cord-028721-x6f26ahr 4293 26 with with IN cord-028721-x6f26ahr 4293 27 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4293 28 's 's POS cord-028721-x6f26ahr 4293 29 syndrome syndrome NN cord-028721-x6f26ahr 4293 30 Hematologic Hematologic NNP cord-028721-x6f26ahr 4293 31 malignancies malignancy NNS cord-028721-x6f26ahr 4293 32 and and CC cord-028721-x6f26ahr 4293 33 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4293 34 syndrome syndrome NN cord-028721-x6f26ahr 4293 35 . . . cord-028721-x6f26ahr 4294 1 A a DT cord-028721-x6f26ahr 4294 2 chance chance NN cord-028721-x6f26ahr 4294 3 association association NN cord-028721-x6f26ahr 4294 4 ? ? . cord-028721-x6f26ahr 4295 1 Prostate prostate NN cord-028721-x6f26ahr 4295 2 cancer cancer NN cord-028721-x6f26ahr 4295 3 in in IN cord-028721-x6f26ahr 4295 4 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4295 5 syndrome syndrome NN cord-028721-x6f26ahr 4295 6 during during IN cord-028721-x6f26ahr 4295 7 hormonal hormonal JJ cord-028721-x6f26ahr 4295 8 replacement replacement NN cord-028721-x6f26ahr 4295 9 therapy therapy NN cord-028721-x6f26ahr 4296 1 The the DT cord-028721-x6f26ahr 4296 2 prepubertal prepubertal JJ cord-028721-x6f26ahr 4296 3 testicular testicular JJ cord-028721-x6f26ahr 4296 4 lesion lesion NN cord-028721-x6f26ahr 4296 5 in in IN cord-028721-x6f26ahr 4296 6 chromatin chromatin NN cord-028721-x6f26ahr 4296 7 - - HYPH cord-028721-x6f26ahr 4296 8 positive positive JJ cord-028721-x6f26ahr 4296 9 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4296 10 's 's POS cord-028721-x6f26ahr 4296 11 syndrome syndrome NN cord-028721-x6f26ahr 4296 12 ( ( -LRB- cord-028721-x6f26ahr 4296 13 primary primary JJ cord-028721-x6f26ahr 4296 14 micro micro JJ cord-028721-x6f26ahr 4296 15 - - JJ cord-028721-x6f26ahr 4296 16 orchidism orchidism JJ cord-028721-x6f26ahr 4296 17 ) ) -RRB- cord-028721-x6f26ahr 4296 18 . . . cord-028721-x6f26ahr 4297 1 As as IN cord-028721-x6f26ahr 4297 2 seen see VBN cord-028721-x6f26ahr 4297 3 in in IN cord-028721-x6f26ahr 4297 4 mentally mentally RB cord-028721-x6f26ahr 4297 5 handicapped handicapped JJ cord-028721-x6f26ahr 4297 6 children child NNS cord-028721-x6f26ahr 4297 7 Mental mental JJ cord-028721-x6f26ahr 4297 8 development development NN cord-028721-x6f26ahr 4297 9 in in IN cord-028721-x6f26ahr 4297 10 polysomy polysomy NN cord-028721-x6f26ahr 4297 11 X X NNP cord-028721-x6f26ahr 4297 12 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 13 syndrome syndrome NN cord-028721-x6f26ahr 4297 14 ( ( -LRB- cord-028721-x6f26ahr 4297 15 47,XXY 47,xxy JJ cord-028721-x6f26ahr 4297 16 ; ; : cord-028721-x6f26ahr 4297 17 48,XXXY 48,xxxy CD cord-028721-x6f26ahr 4297 18 ) ) -RRB- cord-028721-x6f26ahr 4297 19 : : : cord-028721-x6f26ahr 4297 20 effects effect NNS cord-028721-x6f26ahr 4297 21 of of IN cord-028721-x6f26ahr 4297 22 incomplete incomplete JJ cord-028721-x6f26ahr 4297 23 X x NN cord-028721-x6f26ahr 4297 24 inactivation inactivation NN cord-028721-x6f26ahr 4297 25 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 26 syndrome syndrome NN cord-028721-x6f26ahr 4297 27 is be VBZ cord-028721-x6f26ahr 4297 28 a a DT cord-028721-x6f26ahr 4297 29 common common JJ cord-028721-x6f26ahr 4297 30 cause cause NN cord-028721-x6f26ahr 4297 31 for for IN cord-028721-x6f26ahr 4297 32 mental mental JJ cord-028721-x6f26ahr 4297 33 retardation retardation NN cord-028721-x6f26ahr 4297 34 of of IN cord-028721-x6f26ahr 4297 35 unknown unknown JJ cord-028721-x6f26ahr 4297 36 etiology etiology NN cord-028721-x6f26ahr 4297 37 among among IN cord-028721-x6f26ahr 4297 38 prepubertal prepubertal JJ cord-028721-x6f26ahr 4297 39 males male NNS cord-028721-x6f26ahr 4297 40 Growth growth NN cord-028721-x6f26ahr 4297 41 and and CC cord-028721-x6f26ahr 4297 42 body body NN cord-028721-x6f26ahr 4297 43 proportions proportion NNS cord-028721-x6f26ahr 4297 44 in in IN cord-028721-x6f26ahr 4297 45 54 54 CD cord-028721-x6f26ahr 4297 46 boys boy NNS cord-028721-x6f26ahr 4297 47 and and CC cord-028721-x6f26ahr 4297 48 men man NNS cord-028721-x6f26ahr 4297 49 with with IN cord-028721-x6f26ahr 4297 50 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 51 's 's POS cord-028721-x6f26ahr 4297 52 syndrome syndrome NN cord-028721-x6f26ahr 4297 53 Disorders disorder NNS cord-028721-x6f26ahr 4297 54 of of IN cord-028721-x6f26ahr 4297 55 sex sex NN cord-028721-x6f26ahr 4297 56 differentiation differentiation NN cord-028721-x6f26ahr 4297 57 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 58 syndrome syndrome NN cord-028721-x6f26ahr 4297 59 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 60 syndrome syndrome NN cord-028721-x6f26ahr 4297 61 and and CC cord-028721-x6f26ahr 4297 62 its -PRON- PRP$ cord-028721-x6f26ahr 4297 63 variants variant NNS cord-028721-x6f26ahr 4297 64 : : : cord-028721-x6f26ahr 4297 65 an an DT cord-028721-x6f26ahr 4297 66 update update NN cord-028721-x6f26ahr 4297 67 and and CC cord-028721-x6f26ahr 4297 68 review review NN cord-028721-x6f26ahr 4297 69 for for IN cord-028721-x6f26ahr 4297 70 the the DT cord-028721-x6f26ahr 4297 71 primary primary JJ cord-028721-x6f26ahr 4297 72 pediatrician pediatrician NN cord-028721-x6f26ahr 4297 73 Early early JJ cord-028721-x6f26ahr 4297 74 androgen androgen NN cord-028721-x6f26ahr 4297 75 defi defi NNP cord-028721-x6f26ahr 4297 76 ciency ciency NN cord-028721-x6f26ahr 4297 77 in in IN cord-028721-x6f26ahr 4297 78 infants infant NNS cord-028721-x6f26ahr 4297 79 and and CC cord-028721-x6f26ahr 4297 80 young young JJ cord-028721-x6f26ahr 4297 81 boys boy NNS cord-028721-x6f26ahr 4297 82 with with IN cord-028721-x6f26ahr 4297 83 47,XXY 47,xxy JJ cord-028721-x6f26ahr 4297 84 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 85 syndrome syndrome NN cord-028721-x6f26ahr 4297 86 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 87 's 's POS cord-028721-x6f26ahr 4297 88 syndrome syndrome NN cord-028721-x6f26ahr 4297 89 in in IN cord-028721-x6f26ahr 4297 90 a a DT cord-028721-x6f26ahr 4297 91 ten ten CD cord-028721-x6f26ahr 4297 92 month month NN cord-028721-x6f26ahr 4297 93 old old JJ cord-028721-x6f26ahr 4297 94 mongolian mongolian JJ cord-028721-x6f26ahr 4297 95 idiot idiot NN cord-028721-x6f26ahr 4297 96 Síndrome Síndrome NNP cord-028721-x6f26ahr 4297 97 de de NNP cord-028721-x6f26ahr 4297 98 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4297 99 's 's POS cord-028721-x6f26ahr 4297 100 XXY XXY NNP cord-028721-x6f26ahr 4297 101 en en FW cord-028721-x6f26ahr 4297 102 el el NNP cord-028721-x6f26ahr 4297 103 periodo periodo NNP cord-028721-x6f26ahr 4297 104 prepuberal prepuberal NNP cord-028721-x6f26ahr 4297 105 . . . cord-028721-x6f26ahr 4298 1 Estudio Estudio NNP cord-028721-x6f26ahr 4298 2 de de NNP cord-028721-x6f26ahr 4298 3 ocho ocho NNP cord-028721-x6f26ahr 4298 4 observaciones observaciones NNP cord-028721-x6f26ahr 4298 5 Natural Natural NNP cord-028721-x6f26ahr 4298 6 history history NN cord-028721-x6f26ahr 4298 7 of of IN cord-028721-x6f26ahr 4298 8 seminiferous seminiferous JJ cord-028721-x6f26ahr 4298 9 tubule tubule NN cord-028721-x6f26ahr 4298 10 degeneration degeneration NN cord-028721-x6f26ahr 4298 11 in in IN cord-028721-x6f26ahr 4298 12 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4298 13 syndrome syndrome NN cord-028721-x6f26ahr 4298 14 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4298 15 syndrome syndrome NN cord-028721-x6f26ahr 4298 16 and and CC cord-028721-x6f26ahr 4298 17 mediastinal mediastinal JJ cord-028721-x6f26ahr 4298 18 germ germ NN cord-028721-x6f26ahr 4298 19 cell cell NN cord-028721-x6f26ahr 4298 20 tumors tumor NNS cord-028721-x6f26ahr 4299 1 Central central JJ cord-028721-x6f26ahr 4299 2 precocious precocious JJ cord-028721-x6f26ahr 4299 3 puberty puberty NN cord-028721-x6f26ahr 4299 4 in in IN cord-028721-x6f26ahr 4299 5 48,XXYY 48,xxyy CD cord-028721-x6f26ahr 4299 6 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4299 7 syndrome syndrome NN cord-028721-x6f26ahr 4299 8 variant variant NN cord-028721-x6f26ahr 4299 9 A a DT cord-028721-x6f26ahr 4299 10 case case NN cord-028721-x6f26ahr 4299 11 of of IN cord-028721-x6f26ahr 4299 12 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4299 13 's 's POS cord-028721-x6f26ahr 4299 14 syndrome syndrome NN cord-028721-x6f26ahr 4299 15 with with IN cord-028721-x6f26ahr 4299 16 acquired acquire VBN cord-028721-x6f26ahr 4299 17 hypopituitarism hypopituitarism NN cord-028721-x6f26ahr 4299 18 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4299 19 's 's POS cord-028721-x6f26ahr 4299 20 syndrome syndrome NN cord-028721-x6f26ahr 4299 21 with with IN cord-028721-x6f26ahr 4299 22 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4299 23 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 4300 1 Chromatinpositive Chromatinpositive NNP cord-028721-x6f26ahr 4300 2 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4300 3 's 's POS cord-028721-x6f26ahr 4300 4 syndrome syndrome NN cord-028721-x6f26ahr 4300 5 with with IN cord-028721-x6f26ahr 4300 6 undetectable undetectable JJ cord-028721-x6f26ahr 4300 7 peripheral peripheral JJ cord-028721-x6f26ahr 4300 8 FSH fsh NN cord-028721-x6f26ahr 4300 9 levels level NNS cord-028721-x6f26ahr 4300 10 A a DT cord-028721-x6f26ahr 4300 11 case case NN cord-028721-x6f26ahr 4300 12 of of IN cord-028721-x6f26ahr 4300 13 hypogonadotrophic hypogonadotrophic JJ cord-028721-x6f26ahr 4300 14 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4300 15 with with IN cord-028721-x6f26ahr 4300 16 an an DT cord-028721-x6f26ahr 4300 17 XY XY NNP cord-028721-x6f26ahr 4300 18 / / SYM cord-028721-x6f26ahr 4300 19 XXY XXY NNP cord-028721-x6f26ahr 4300 20 chromosome chromosome NN cord-028721-x6f26ahr 4300 21 mosaicism mosaicism NN cord-028721-x6f26ahr 4301 1 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4301 2 's 's POS cord-028721-x6f26ahr 4301 3 syndrome syndrome NN cord-028721-x6f26ahr 4301 4 with with IN cord-028721-x6f26ahr 4301 5 hypogonadotrophic hypogonadotrophic NNP cord-028721-x6f26ahr 4301 6 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4301 7 XXY XXY NNP cord-028721-x6f26ahr 4301 8 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4301 9 's 's POS cord-028721-x6f26ahr 4301 10 syndrome syndrome NN cord-028721-x6f26ahr 4301 11 with with IN cord-028721-x6f26ahr 4301 12 low low JJ cord-028721-x6f26ahr 4301 13 FSH fsh NN cord-028721-x6f26ahr 4301 14 and and CC cord-028721-x6f26ahr 4301 15 LH LH NNP cord-028721-x6f26ahr 4301 16 levels level NNS cord-028721-x6f26ahr 4301 17 and and CC cord-028721-x6f26ahr 4301 18 absence absence NN cord-028721-x6f26ahr 4301 19 of of IN cord-028721-x6f26ahr 4301 20 Leydig Leydig NNP cord-028721-x6f26ahr 4301 21 cells cell NNS cord-028721-x6f26ahr 4301 22 A a DT cord-028721-x6f26ahr 4301 23 case case NN cord-028721-x6f26ahr 4301 24 of of IN cord-028721-x6f26ahr 4301 25 XX xx JJ cord-028721-x6f26ahr 4301 26 - - HYPH cord-028721-x6f26ahr 4301 27 male male JJ cord-028721-x6f26ahr 4301 28 syndrome syndrome NN cord-028721-x6f26ahr 4301 29 45X/46XX 45x/46xx CD cord-028721-x6f26ahr 4301 30 boy boy NN cord-028721-x6f26ahr 4301 31 with with IN cord-028721-x6f26ahr 4301 32 hypospadias hypospadia NNS cord-028721-x6f26ahr 4301 33 : : : cord-028721-x6f26ahr 4301 34 case case NN cord-028721-x6f26ahr 4301 35 report report NN cord-028721-x6f26ahr 4301 36 XX XX NNP cord-028721-x6f26ahr 4301 37 sex sex NN cord-028721-x6f26ahr 4301 38 chromosomes chromosome NNS cord-028721-x6f26ahr 4301 39 in in IN cord-028721-x6f26ahr 4301 40 a a DT cord-028721-x6f26ahr 4301 41 human human JJ cord-028721-x6f26ahr 4301 42 male male NN cord-028721-x6f26ahr 4301 43 . . . cord-028721-x6f26ahr 4302 1 First first JJ cord-028721-x6f26ahr 4302 2 case case NN cord-028721-x6f26ahr 4302 3 XX xx NN cord-028721-x6f26ahr 4302 4 sex sex NN cord-028721-x6f26ahr 4302 5 reversal reversal NN cord-028721-x6f26ahr 4302 6 , , , cord-028721-x6f26ahr 4302 7 palmoplantar palmoplantar NNP cord-028721-x6f26ahr 4302 8 keratoderma keratoderma NNP cord-028721-x6f26ahr 4302 9 , , , cord-028721-x6f26ahr 4302 10 and and CC cord-028721-x6f26ahr 4302 11 predisposition predisposition NN cord-028721-x6f26ahr 4302 12 to to IN cord-028721-x6f26ahr 4302 13 squamous squamous JJ cord-028721-x6f26ahr 4302 14 cell cell NN cord-028721-x6f26ahr 4302 15 carcinoma carcinoma NN cord-028721-x6f26ahr 4302 16 : : : cord-028721-x6f26ahr 4302 17 genetic genetic JJ cord-028721-x6f26ahr 4302 18 analysis analysis NN cord-028721-x6f26ahr 4302 19 in in IN cord-028721-x6f26ahr 4302 20 one one CD cord-028721-x6f26ahr 4302 21 family family NN cord-028721-x6f26ahr 4302 22 Analytic analytic JJ cord-028721-x6f26ahr 4302 23 review review NN cord-028721-x6f26ahr 4302 24 : : : cord-028721-x6f26ahr 4302 25 Nature nature NN cord-028721-x6f26ahr 4302 26 and and CC cord-028721-x6f26ahr 4302 27 origin origin NN cord-028721-x6f26ahr 4302 28 of of IN cord-028721-x6f26ahr 4302 29 males male NNS cord-028721-x6f26ahr 4302 30 with with IN cord-028721-x6f26ahr 4302 31 XX xx NN cord-028721-x6f26ahr 4302 32 sex sex NN cord-028721-x6f26ahr 4302 33 chromosomes chromosome NNS cord-028721-x6f26ahr 4302 34 Leydig leydig NN cord-028721-x6f26ahr 4302 35 cell cell NN cord-028721-x6f26ahr 4302 36 ultrastructure ultrastructure NN cord-028721-x6f26ahr 4302 37 in in IN cord-028721-x6f26ahr 4302 38 an an DT cord-028721-x6f26ahr 4302 39 XX XX NNP cord-028721-x6f26ahr 4302 40 male male NN cord-028721-x6f26ahr 4302 41 Varón Varón NNP cord-028721-x6f26ahr 4302 42 con con NN cord-028721-x6f26ahr 4302 43 cariotipo cariotipo NN cord-028721-x6f26ahr 4302 44 46 46 CD cord-028721-x6f26ahr 4302 45 XX XX NNP cord-028721-x6f26ahr 4302 46 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 4302 47 of of IN cord-028721-x6f26ahr 4302 48 testicular testicular JJ cord-028721-x6f26ahr 4302 49 biopsy biopsy NN cord-028721-x6f26ahr 4302 50 from from IN cord-028721-x6f26ahr 4302 51 an an DT cord-028721-x6f26ahr 4302 52 XX XX NNP cord-028721-x6f26ahr 4302 53 male male NN cord-028721-x6f26ahr 4302 54 Le Le NNP cord-028721-x6f26ahr 4302 55 testicule testicule NNP cord-028721-x6f26ahr 4302 56 chez chez NNP cord-028721-x6f26ahr 4302 57 l'homme l'homme NNP cord-028721-x6f26ahr 4302 58 46 46 CD cord-028721-x6f26ahr 4302 59 , , , cord-028721-x6f26ahr 4303 1 XX XX NNP cord-028721-x6f26ahr 4303 2 : : : cord-028721-x6f26ahr 4304 1 A a DT cord-028721-x6f26ahr 4304 2 propos propos NN cord-028721-x6f26ahr 4304 3 d'une d'une NNP cord-028721-x6f26ahr 4304 4 observation observation NN cord-028721-x6f26ahr 4304 5 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4304 6 Ultrastructure Ultrastructure NNP cord-028721-x6f26ahr 4304 7 of of IN cord-028721-x6f26ahr 4304 8 the the DT cord-028721-x6f26ahr 4304 9 testis testis NN cord-028721-x6f26ahr 4304 10 in in IN cord-028721-x6f26ahr 4304 11 an an DT cord-028721-x6f26ahr 4304 12 XX xx NN cord-028721-x6f26ahr 4304 13 male male NN cord-028721-x6f26ahr 4304 14 with with IN cord-028721-x6f26ahr 4304 15 normal normal JJ cord-028721-x6f26ahr 4304 16 plasma plasma NN cord-028721-x6f26ahr 4304 17 testosterone testosterone NN cord-028721-x6f26ahr 4304 18 Sex sex NN cord-028721-x6f26ahr 4304 19 determination determination NN cord-028721-x6f26ahr 4304 20 and and CC cord-028721-x6f26ahr 4304 21 sex sex NN cord-028721-x6f26ahr 4304 22 reversal reversal NN cord-028721-x6f26ahr 4304 23 : : : cord-028721-x6f26ahr 4304 24 genotype genotype NN cord-028721-x6f26ahr 4304 25 , , , cord-028721-x6f26ahr 4304 26 phenotype phenotype NN cord-028721-x6f26ahr 4304 27 , , , cord-028721-x6f26ahr 4304 28 dogma dogma NN cord-028721-x6f26ahr 4304 29 and and CC cord-028721-x6f26ahr 4304 30 semantics semantic NNS cord-028721-x6f26ahr 4304 31 Clinical clinical JJ cord-028721-x6f26ahr 4304 32 case case NN cord-028721-x6f26ahr 4304 33 of of IN cord-028721-x6f26ahr 4304 34 the the DT cord-028721-x6f26ahr 4304 35 month month NN cord-028721-x6f26ahr 4304 36 . . . cord-028721-x6f26ahr 4305 1 A a DT cord-028721-x6f26ahr 4305 2 male male NN cord-028721-x6f26ahr 4305 3 with with IN cord-028721-x6f26ahr 4305 4 46,XX 46,xx CD cord-028721-x6f26ahr 4305 5 karyotype karyotype NN cord-028721-x6f26ahr 4305 6 X x NN cord-028721-x6f26ahr 4305 7 - - HYPH cord-028721-x6f26ahr 4305 8 Y Y NNP cord-028721-x6f26ahr 4305 9 chromosomal chromosomal JJ cord-028721-x6f26ahr 4305 10 interchange interchange NN cord-028721-x6f26ahr 4305 11 in in IN cord-028721-x6f26ahr 4305 12 the the DT cord-028721-x6f26ahr 4305 13 etiology etiology NN cord-028721-x6f26ahr 4305 14 of of IN cord-028721-x6f26ahr 4305 15 true true JJ cord-028721-x6f26ahr 4305 16 hermaphroditism hermaphroditism NNS cord-028721-x6f26ahr 4305 17 and and CC cord-028721-x6f26ahr 4305 18 of of IN cord-028721-x6f26ahr 4305 19 XX XX NNP cord-028721-x6f26ahr 4305 20 Klinefelter Klinefelter NNP cord-028721-x6f26ahr 4305 21 's 's POS cord-028721-x6f26ahr 4305 22 syndrome syndrome NN cord-028721-x6f26ahr 4306 1 A a DT cord-028721-x6f26ahr 4306 2 possible possible JJ cord-028721-x6f26ahr 4306 3 etiology etiology NN cord-028721-x6f26ahr 4306 4 of of IN cord-028721-x6f26ahr 4306 5 the the DT cord-028721-x6f26ahr 4306 6 infertile infertile JJ cord-028721-x6f26ahr 4306 7 46 46 CD cord-028721-x6f26ahr 4306 8 XX xx NN cord-028721-x6f26ahr 4306 9 male male JJ cord-028721-x6f26ahr 4306 10 subject subject NN cord-028721-x6f26ahr 4306 11 Deletion deletion NN cord-028721-x6f26ahr 4306 12 mapping mapping NN cord-028721-x6f26ahr 4306 13 of of IN cord-028721-x6f26ahr 4306 14 the the DT cord-028721-x6f26ahr 4306 15 testis testis NN cord-028721-x6f26ahr 4306 16 determining determine VBG cord-028721-x6f26ahr 4306 17 locus locus NN cord-028721-x6f26ahr 4306 18 with with IN cord-028721-x6f26ahr 4306 19 DNA dna NN cord-028721-x6f26ahr 4306 20 probes probe NNS cord-028721-x6f26ahr 4306 21 in in IN cord-028721-x6f26ahr 4306 22 46 46 CD cord-028721-x6f26ahr 4306 23 XX XX NNP cord-028721-x6f26ahr 4306 24 males male NNS cord-028721-x6f26ahr 4306 25 and and CC cord-028721-x6f26ahr 4306 26 46 46 CD cord-028721-x6f26ahr 4306 27 XY XY NNP cord-028721-x6f26ahr 4306 28 and and CC cord-028721-x6f26ahr 4306 29 46 46 CD cord-028721-x6f26ahr 4306 30 X x NN cord-028721-x6f26ahr 4306 31 dic dic NN cord-028721-x6f26ahr 4306 32 ( ( -LRB- cord-028721-x6f26ahr 4306 33 Y Y NNP cord-028721-x6f26ahr 4306 34 ) ) -RRB- cord-028721-x6f26ahr 4306 35 females female NNS cord-028721-x6f26ahr 4306 36 DNA dna NN cord-028721-x6f26ahr 4306 37 hybridization hybridization NN cord-028721-x6f26ahr 4306 38 study study NN cord-028721-x6f26ahr 4306 39 using use VBG cord-028721-x6f26ahr 4306 40 Yspecifi Yspecifi NNP cord-028721-x6f26ahr 4306 41 c c NNP cord-028721-x6f26ahr 4306 42 probes probe NNS cord-028721-x6f26ahr 4306 43 in in IN cord-028721-x6f26ahr 4306 44 an an DT cord-028721-x6f26ahr 4306 45 XX xx JJ cord-028721-x6f26ahr 4306 46 - - HYPH cord-028721-x6f26ahr 4306 47 male male JJ cord-028721-x6f26ahr 4306 48 Localization localization NN cord-028721-x6f26ahr 4306 49 of of IN cord-028721-x6f26ahr 4306 50 the the DT cord-028721-x6f26ahr 4306 51 sex sex NN cord-028721-x6f26ahr 4306 52 - - HYPH cord-028721-x6f26ahr 4306 53 determining determine VBG cord-028721-x6f26ahr 4306 54 region region NN cord-028721-x6f26ahr 4306 55 - - : cord-028721-x6f26ahr 4306 56 Y y NN cord-028721-x6f26ahr 4306 57 gene gene NN cord-028721-x6f26ahr 4306 58 in in IN cord-028721-x6f26ahr 4306 59 XX XX NNP cord-028721-x6f26ahr 4306 60 males male NNS cord-028721-x6f26ahr 4307 1 XX XX NNP cord-028721-x6f26ahr 4307 2 male male NN cord-028721-x6f26ahr 4307 3 : : : cord-028721-x6f26ahr 4307 4 clinical clinical JJ cord-028721-x6f26ahr 4307 5 , , , cord-028721-x6f26ahr 4307 6 hormonal/ hormonal/ CD cord-028721-x6f26ahr 4308 1 genetic genetic JJ cord-028721-x6f26ahr 4308 2 fi fi NNP cord-028721-x6f26ahr 4308 3 ndings nding NNS cord-028721-x6f26ahr 4308 4 A a DT cord-028721-x6f26ahr 4308 5 comparative comparative JJ cord-028721-x6f26ahr 4308 6 genomic genomic JJ cord-028721-x6f26ahr 4308 7 hybridization hybridization NN cord-028721-x6f26ahr 4308 8 study study NN cord-028721-x6f26ahr 4308 9 in in IN cord-028721-x6f26ahr 4308 10 a a DT cord-028721-x6f26ahr 4308 11 46,XX 46,xx CD cord-028721-x6f26ahr 4308 12 male male NN cord-028721-x6f26ahr 4309 1 An an DT cord-028721-x6f26ahr 4309 2 XX xx NN cord-028721-x6f26ahr 4309 3 male male NN cord-028721-x6f26ahr 4309 4 with with IN cord-028721-x6f26ahr 4309 5 the the DT cord-028721-x6f26ahr 4309 6 sexdetermining sexdetermining NN cord-028721-x6f26ahr 4309 7 region region NN cord-028721-x6f26ahr 4309 8 Y Y NNP cord-028721-x6f26ahr 4309 9 gene gene NN cord-028721-x6f26ahr 4309 10 inserted insert VBN cord-028721-x6f26ahr 4309 11 in in IN cord-028721-x6f26ahr 4309 12 the the DT cord-028721-x6f26ahr 4309 13 long long JJ cord-028721-x6f26ahr 4309 14 arm arm NN cord-028721-x6f26ahr 4309 15 of of IN cord-028721-x6f26ahr 4309 16 chromosome chromosome NN cord-028721-x6f26ahr 4309 17 16 16 CD cord-028721-x6f26ahr 4310 1 Deoxyribonucleic deoxyribonucleic NN cord-028721-x6f26ahr 4310 2 acid acid NN cord-028721-x6f26ahr 4310 3 and and CC cord-028721-x6f26ahr 4310 4 cytological cytological JJ cord-028721-x6f26ahr 4310 5 detection detection NN cord-028721-x6f26ahr 4310 6 of of IN cord-028721-x6f26ahr 4310 7 Y Y NNP cord-028721-x6f26ahr 4310 8 - - HYPH cord-028721-x6f26ahr 4310 9 containing contain VBG cord-028721-x6f26ahr 4310 10 cells cell NNS cord-028721-x6f26ahr 4310 11 in in IN cord-028721-x6f26ahr 4310 12 a a DT cord-028721-x6f26ahr 4310 13 XX XX NNP cord-028721-x6f26ahr 4310 14 hypospadic hypospadic NNP cord-028721-x6f26ahr 4310 15 boy boy NN cord-028721-x6f26ahr 4310 16 with with IN cord-028721-x6f26ahr 4310 17 polyorchidism polyorchidism NN cord-028721-x6f26ahr 4310 18 XX XX NNP cord-028721-x6f26ahr 4310 19 males male NNS cord-028721-x6f26ahr 4310 20 without without IN cord-028721-x6f26ahr 4310 21 SRY sry NN cord-028721-x6f26ahr 4310 22 gene gene NN cord-028721-x6f26ahr 4310 23 and and CC cord-028721-x6f26ahr 4310 24 with with IN cord-028721-x6f26ahr 4310 25 infertility infertility NN cord-028721-x6f26ahr 4310 26 SRY sry NN cord-028721-x6f26ahr 4310 27 - - HYPH cord-028721-x6f26ahr 4310 28 negative negative JJ cord-028721-x6f26ahr 4310 29 46,XX 46,xx CD cord-028721-x6f26ahr 4310 30 male male NN cord-028721-x6f26ahr 4310 31 with with IN cord-028721-x6f26ahr 4310 32 normal normal JJ cord-028721-x6f26ahr 4310 33 genitals genital NNS cord-028721-x6f26ahr 4310 34 , , , cord-028721-x6f26ahr 4310 35 complete complete JJ cord-028721-x6f26ahr 4310 36 masculinization masculinization NN cord-028721-x6f26ahr 4310 37 and and CC cord-028721-x6f26ahr 4310 38 infertility infertility NN cord-028721-x6f26ahr 4310 39 Genotype genotype NN cord-028721-x6f26ahr 4310 40 - - HYPH cord-028721-x6f26ahr 4310 41 phenotype phenotype NN cord-028721-x6f26ahr 4310 42 correlations correlation NNS cord-028721-x6f26ahr 4310 43 in in IN cord-028721-x6f26ahr 4310 44 XX XX NNP cord-028721-x6f26ahr 4310 45 males male NNS cord-028721-x6f26ahr 4310 46 and and CC cord-028721-x6f26ahr 4310 47 their -PRON- PRP$ cord-028721-x6f26ahr 4310 48 bearing bearing NN cord-028721-x6f26ahr 4310 49 on on IN cord-028721-x6f26ahr 4310 50 current current JJ cord-028721-x6f26ahr 4310 51 theories theory NNS cord-028721-x6f26ahr 4310 52 of of IN cord-028721-x6f26ahr 4310 53 sex sex NN cord-028721-x6f26ahr 4310 54 determination determination NN cord-028721-x6f26ahr 4310 55 A a DT cord-028721-x6f26ahr 4310 56 regulatory regulatory JJ cord-028721-x6f26ahr 4310 57 cascade cascade NN cord-028721-x6f26ahr 4310 58 hypothesis hypothesis NN cord-028721-x6f26ahr 4310 59 for for IN cord-028721-x6f26ahr 4310 60 mammalian mammalian JJ cord-028721-x6f26ahr 4310 61 sex sex NN cord-028721-x6f26ahr 4310 62 determination determination NN cord-028721-x6f26ahr 4311 1 : : : cord-028721-x6f26ahr 4311 2 SRY SRY NNP cord-028721-x6f26ahr 4311 3 represses repress VBZ cord-028721-x6f26ahr 4311 4 a a DT cord-028721-x6f26ahr 4311 5 negative negative JJ cord-028721-x6f26ahr 4311 6 regulator regulator NN cord-028721-x6f26ahr 4311 7 of of IN cord-028721-x6f26ahr 4311 8 male male JJ cord-028721-x6f26ahr 4311 9 development development NN cord-028721-x6f26ahr 4311 10 XX xx NN cord-028721-x6f26ahr 4311 11 sex sex NN cord-028721-x6f26ahr 4311 12 reversal reversal NN cord-028721-x6f26ahr 4311 13 with with IN cord-028721-x6f26ahr 4311 14 partial partial JJ cord-028721-x6f26ahr 4311 15 duplication duplication NN cord-028721-x6f26ahr 4311 16 of of IN cord-028721-x6f26ahr 4311 17 chromosome chromosome NN cord-028721-x6f26ahr 4311 18 arm arm NN cord-028721-x6f26ahr 4311 19 22q 22q CD cord-028721-x6f26ahr 4311 20 Clinical clinical JJ cord-028721-x6f26ahr 4311 21 , , , cord-028721-x6f26ahr 4311 22 hormonal hormonal JJ cord-028721-x6f26ahr 4311 23 and and CC cord-028721-x6f26ahr 4311 24 cytogenetic cytogenetic JJ cord-028721-x6f26ahr 4311 25 evaluation evaluation NN cord-028721-x6f26ahr 4311 26 of of IN cord-028721-x6f26ahr 4311 27 46,XX 46,xx CD cord-028721-x6f26ahr 4311 28 males male NNS cord-028721-x6f26ahr 4311 29 and and CC cord-028721-x6f26ahr 4311 30 review review NN cord-028721-x6f26ahr 4311 31 of of IN cord-028721-x6f26ahr 4311 32 the the DT cord-028721-x6f26ahr 4311 33 literature literature NN cord-028721-x6f26ahr 4312 1 XYY XYY NNP cord-028721-x6f26ahr 4312 2 human human JJ cord-028721-x6f26ahr 4312 3 male male NN cord-028721-x6f26ahr 4312 4 XYY XYY NNP cord-028721-x6f26ahr 4312 5 chromosome chromosome NN cord-028721-x6f26ahr 4312 6 abnormality abnormality NN cord-028721-x6f26ahr 4312 7 in in IN cord-028721-x6f26ahr 4312 8 sexual sexual JJ cord-028721-x6f26ahr 4312 9 homicide homicide NN cord-028721-x6f26ahr 4312 10 perpetrators perpetrator NNS cord-028721-x6f26ahr 4313 1 The the DT cord-028721-x6f26ahr 4313 2 XYY XYY NNP cord-028721-x6f26ahr 4313 3 syndrome syndrome NN cord-028721-x6f26ahr 4313 4 : : : cord-028721-x6f26ahr 4313 5 a a DT cord-028721-x6f26ahr 4313 6 follow follow VB cord-028721-x6f26ahr 4313 7 - - HYPH cord-028721-x6f26ahr 4313 8 up up NN cord-028721-x6f26ahr 4313 9 study study NN cord-028721-x6f26ahr 4313 10 on on IN cord-028721-x6f26ahr 4313 11 38 38 CD cord-028721-x6f26ahr 4313 12 boys boy NNS cord-028721-x6f26ahr 4313 13 Testicular testicular JJ cord-028721-x6f26ahr 4313 14 function function NN cord-028721-x6f26ahr 4313 15 in in IN cord-028721-x6f26ahr 4313 16 XYY XYY NNP cord-028721-x6f26ahr 4313 17 men man NNS cord-028721-x6f26ahr 4313 18 Quantifi Quantifi NNP cord-028721-x6f26ahr 4313 19 cation cation NN cord-028721-x6f26ahr 4313 20 of of IN cord-028721-x6f26ahr 4313 21 human human JJ cord-028721-x6f26ahr 4313 22 seminiferous seminiferous JJ cord-028721-x6f26ahr 4313 23 epithelium epithelium NN cord-028721-x6f26ahr 4313 24 . . . cord-028721-x6f26ahr 4314 1 II II NNP cord-028721-x6f26ahr 4314 2 . . . cord-028721-x6f26ahr 4315 1 Histological Histological NNP cord-028721-x6f26ahr 4315 2 studies study NNS cord-028721-x6f26ahr 4315 3 in in IN cord-028721-x6f26ahr 4315 4 eight eight CD cord-028721-x6f26ahr 4315 5 47 47 CD cord-028721-x6f26ahr 4315 6 , , , cord-028721-x6f26ahr 4315 7 XYY XYY NNP cord-028721-x6f26ahr 4315 8 men man NNS cord-028721-x6f26ahr 4315 9 Persistence Persistence NNP cord-028721-x6f26ahr 4315 10 of of IN cord-028721-x6f26ahr 4315 11 two two CD cord-028721-x6f26ahr 4315 12 Y Y NNP cord-028721-x6f26ahr 4315 13 chromosomes chromosome NNS cord-028721-x6f26ahr 4315 14 through through IN cord-028721-x6f26ahr 4315 15 meiotic meiotic JJ cord-028721-x6f26ahr 4315 16 prophase prophase NN cord-028721-x6f26ahr 4315 17 and and CC cord-028721-x6f26ahr 4315 18 metaphase metaphase NN cord-028721-x6f26ahr 4316 1 I -PRON- PRP cord-028721-x6f26ahr 4316 2 in in IN cord-028721-x6f26ahr 4316 3 an an DT cord-028721-x6f26ahr 4316 4 XYY XYY NNP cord-028721-x6f26ahr 4316 5 man man NN cord-028721-x6f26ahr 4316 6 From from IN cord-028721-x6f26ahr 4316 7 spermatocytes spermatocyte NNS cord-028721-x6f26ahr 4316 8 to to IN cord-028721-x6f26ahr 4316 9 spermatozoa spermatozoa VB cord-028721-x6f26ahr 4316 10 in in IN cord-028721-x6f26ahr 4316 11 an an DT cord-028721-x6f26ahr 4316 12 infertile infertile JJ cord-028721-x6f26ahr 4316 13 XYY XYY NNP cord-028721-x6f26ahr 4316 14 male male NN cord-028721-x6f26ahr 4316 15 Sex sex NN cord-028721-x6f26ahr 4316 16 chromosome chromosome NN cord-028721-x6f26ahr 4316 17 pairing pairing NN cord-028721-x6f26ahr 4316 18 and and CC cord-028721-x6f26ahr 4316 19 male male JJ cord-028721-x6f26ahr 4316 20 fertility fertility NN cord-028721-x6f26ahr 4317 1 The the DT cord-028721-x6f26ahr 4317 2 role role NN cord-028721-x6f26ahr 4317 3 of of IN cord-028721-x6f26ahr 4317 4 unpaired unpaired JJ cord-028721-x6f26ahr 4317 5 sex sex NN cord-028721-x6f26ahr 4317 6 chromosomes chromosome NNS cord-028721-x6f26ahr 4317 7 in in IN cord-028721-x6f26ahr 4317 8 spermatogenetic spermatogenetic NN cord-028721-x6f26ahr 4317 9 failure failure NN cord-028721-x6f26ahr 4317 10 Evidence evidence NN cord-028721-x6f26ahr 4317 11 for for IN cord-028721-x6f26ahr 4317 12 an an DT cord-028721-x6f26ahr 4317 13 association association NN cord-028721-x6f26ahr 4317 14 between between IN cord-028721-x6f26ahr 4317 15 univalent univalent NNP cord-028721-x6f26ahr 4317 16 Y Y NNP cord-028721-x6f26ahr 4317 17 chromosomes chromosome NNS cord-028721-x6f26ahr 4317 18 and and CC cord-028721-x6f26ahr 4317 19 spermatocyte spermatocyte JJ cord-028721-x6f26ahr 4317 20 loss loss NN cord-028721-x6f26ahr 4317 21 in in IN cord-028721-x6f26ahr 4317 22 XYY XYY NNP cord-028721-x6f26ahr 4317 23 mice mouse NNS cord-028721-x6f26ahr 4317 24 and and CC cord-028721-x6f26ahr 4317 25 men man NNS cord-028721-x6f26ahr 4317 26 Meiosis meiosis VBP cord-028721-x6f26ahr 4317 27 in in IN cord-028721-x6f26ahr 4317 28 XYY XYY NNP cord-028721-x6f26ahr 4317 29 men man NNS cord-028721-x6f26ahr 4317 30 Pituitary Pituitary NNP cord-028721-x6f26ahr 4317 31 gonadotrophins gonadotrophin NNS cord-028721-x6f26ahr 4317 32 and and CC cord-028721-x6f26ahr 4317 33 17-ketosteroids 17-ketosteroids CD cord-028721-x6f26ahr 4317 34 in in IN cord-028721-x6f26ahr 4317 35 patients patient NNS cord-028721-x6f26ahr 4317 36 with with IN cord-028721-x6f26ahr 4317 37 the the DT cord-028721-x6f26ahr 4317 38 XYY XYY NNP cord-028721-x6f26ahr 4317 39 syndrome syndrome NN cord-028721-x6f26ahr 4317 40 Analysis Analysis NNP cord-028721-x6f26ahr 4317 41 of of IN cord-028721-x6f26ahr 4317 42 the the DT cord-028721-x6f26ahr 4317 43 sex sex NN cord-028721-x6f26ahr 4317 44 chromosome chromosome NN cord-028721-x6f26ahr 4317 45 constitution constitution NN cord-028721-x6f26ahr 4317 46 of of IN cord-028721-x6f26ahr 4317 47 sperm sperm NN cord-028721-x6f26ahr 4317 48 in in IN cord-028721-x6f26ahr 4317 49 men man NNS cord-028721-x6f26ahr 4317 50 with with IN cord-028721-x6f26ahr 4317 51 a a DT cord-028721-x6f26ahr 4317 52 47,XYY 47,xyy CD cord-028721-x6f26ahr 4317 53 mosaic mosaic NN cord-028721-x6f26ahr 4317 54 karyotype karyotype NN cord-028721-x6f26ahr 4317 55 by by IN cord-028721-x6f26ahr 4317 56 fl fl NNP cord-028721-x6f26ahr 4317 57 uorescence uorescence NN cord-028721-x6f26ahr 4317 58 in in IN cord-028721-x6f26ahr 4317 59 situ situ NN cord-028721-x6f26ahr 4317 60 hybridization hybridization NN cord-028721-x6f26ahr 4318 1 A a DT cord-028721-x6f26ahr 4318 2 male male JJ cord-028721-x6f26ahr 4318 3 subject subject NN cord-028721-x6f26ahr 4318 4 with with IN cord-028721-x6f26ahr 4318 5 3 3 CD cord-028721-x6f26ahr 4318 6 Y Y NNP cord-028721-x6f26ahr 4318 7 chromosomes chromosome NNS cord-028721-x6f26ahr 4318 8 ( ( -LRB- cord-028721-x6f26ahr 4318 9 48,XYYY 48,xyyy CD cord-028721-x6f26ahr 4318 10 ) ) -RRB- cord-028721-x6f26ahr 4319 1 : : : cord-028721-x6f26ahr 4319 2 A a DT cord-028721-x6f26ahr 4319 3 case case NN cord-028721-x6f26ahr 4319 4 report report NN cord-028721-x6f26ahr 4319 5 Triple Triple NNP cord-028721-x6f26ahr 4319 6 - - HYPH cord-028721-x6f26ahr 4319 7 Y Y NNP cord-028721-x6f26ahr 4319 8 syndrome syndrome NN cord-028721-x6f26ahr 4319 9 following follow VBG cord-028721-x6f26ahr 4319 10 ICSI ICSI NNP cord-028721-x6f26ahr 4319 11 treatment treatment NN cord-028721-x6f26ahr 4319 12 in in IN cord-028721-x6f26ahr 4319 13 a a DT cord-028721-x6f26ahr 4319 14 couple couple NN cord-028721-x6f26ahr 4319 15 with with IN cord-028721-x6f26ahr 4319 16 normal normal JJ cord-028721-x6f26ahr 4319 17 chromosomes chromosome NNS cord-028721-x6f26ahr 4319 18 : : : cord-028721-x6f26ahr 4319 19 case case NN cord-028721-x6f26ahr 4319 20 report report NN cord-028721-x6f26ahr 4319 21 49 49 CD cord-028721-x6f26ahr 4319 22 XYYYY XYYYY NNS cord-028721-x6f26ahr 4319 23 . . . cord-028721-x6f26ahr 4320 1 A a DT cord-028721-x6f26ahr 4320 2 case case NN cord-028721-x6f26ahr 4320 3 report report NN cord-028721-x6f26ahr 4320 4 Tetrasomy Tetrasomy NNP cord-028721-x6f26ahr 4320 5 Y Y NNP cord-028721-x6f26ahr 4320 6 by by IN cord-028721-x6f26ahr 4320 7 structural structural JJ cord-028721-x6f26ahr 4320 8 rearrangement rearrangement NN cord-028721-x6f26ahr 4320 9 : : : cord-028721-x6f26ahr 4320 10 clinical clinical JJ cord-028721-x6f26ahr 4320 11 report report NN cord-028721-x6f26ahr 4320 12 Human Human NNP cord-028721-x6f26ahr 4320 13 Y Y NNP cord-028721-x6f26ahr 4320 14 chromosome chromosome NN cord-028721-x6f26ahr 4320 15 function function NN cord-028721-x6f26ahr 4320 16 in in IN cord-028721-x6f26ahr 4320 17 male male JJ cord-028721-x6f26ahr 4320 18 germ germ NN cord-028721-x6f26ahr 4320 19 cell cell NN cord-028721-x6f26ahr 4320 20 development development NN cord-028721-x6f26ahr 4320 21 ( ( -LRB- cord-028721-x6f26ahr 4320 22 review review NN cord-028721-x6f26ahr 4320 23 ) ) -RRB- cord-028721-x6f26ahr 4321 1 Defi Defi NNP cord-028721-x6f26ahr 4321 2 ning ning NNP cord-028721-x6f26ahr 4321 3 regions region NNS cord-028721-x6f26ahr 4321 4 of of IN cord-028721-x6f26ahr 4321 5 the the DT cord-028721-x6f26ahr 4321 6 Ychromosome Ychromosome NNP cord-028721-x6f26ahr 4321 7 reponsible reponsible JJ cord-028721-x6f26ahr 4321 8 for for IN cord-028721-x6f26ahr 4321 9 male male JJ cord-028721-x6f26ahr 4321 10 infertility infertility NN cord-028721-x6f26ahr 4321 11 and and CC cord-028721-x6f26ahr 4321 12 identifi identifi NNP cord-028721-x6f26ahr 4321 13 cation cation NNP cord-028721-x6f26ahr 4321 14 of of IN cord-028721-x6f26ahr 4321 15 a a DT cord-028721-x6f26ahr 4321 16 fourth fourth JJ cord-028721-x6f26ahr 4321 17 AZF AZF NNP cord-028721-x6f26ahr 4321 18 region region NN cord-028721-x6f26ahr 4321 19 ( ( -LRB- cord-028721-x6f26ahr 4321 20 AZFd AZFd NNS cord-028721-x6f26ahr 4321 21 ) ) -RRB- cord-028721-x6f26ahr 4321 22 by by IN cord-028721-x6f26ahr 4321 23 Ychromosome Ychromosome NNP cord-028721-x6f26ahr 4321 24 microdeletion microdeletion NN cord-028721-x6f26ahr 4321 25 Characterization characterization NN cord-028721-x6f26ahr 4321 26 of of IN cord-028721-x6f26ahr 4321 27 novel novel JJ cord-028721-x6f26ahr 4321 28 genes gene NNS cord-028721-x6f26ahr 4321 29 in in IN cord-028721-x6f26ahr 4321 30 AZF AZF NNP cord-028721-x6f26ahr 4321 31 regions region NNS cord-028721-x6f26ahr 4321 32 Localization Localization NNP cord-028721-x6f26ahr 4321 33 of of IN cord-028721-x6f26ahr 4321 34 factors factor NNS cord-028721-x6f26ahr 4321 35 controlling control VBG cord-028721-x6f26ahr 4321 36 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4321 37 in in IN cord-028721-x6f26ahr 4321 38 the the DT cord-028721-x6f26ahr 4321 39 nonfl nonfl NNP cord-028721-x6f26ahr 4321 40 uorescent uorescent JJ cord-028721-x6f26ahr 4321 41 portion portion NN cord-028721-x6f26ahr 4321 42 of of IN cord-028721-x6f26ahr 4321 43 the the DT cord-028721-x6f26ahr 4321 44 human human JJ cord-028721-x6f26ahr 4321 45 Y Y NNP cord-028721-x6f26ahr 4321 46 chromosome chromosome NN cord-028721-x6f26ahr 4321 47 long long JJ cord-028721-x6f26ahr 4321 48 arm arm NN cord-028721-x6f26ahr 4321 49 Severe severe JJ cord-028721-x6f26ahr 4321 50 oligozoospermia oligozoospermia NN cord-028721-x6f26ahr 4321 51 resulting result VBG cord-028721-x6f26ahr 4321 52 from from IN cord-028721-x6f26ahr 4321 53 deletions deletion NNS cord-028721-x6f26ahr 4321 54 of of IN cord-028721-x6f26ahr 4321 55 References reference NNS cord-028721-x6f26ahr 4321 56 azoospermia azoospermia NN cord-028721-x6f26ahr 4321 57 factor factor NN cord-028721-x6f26ahr 4321 58 gene gene NN cord-028721-x6f26ahr 4321 59 on on IN cord-028721-x6f26ahr 4321 60 Y Y NNP cord-028721-x6f26ahr 4321 61 chromosome chromosome NN cord-028721-x6f26ahr 4321 62 Yq Yq NNP cord-028721-x6f26ahr 4321 63 deletion deletion NN cord-028721-x6f26ahr 4321 64 and and CC cord-028721-x6f26ahr 4321 65 failure failure NN cord-028721-x6f26ahr 4321 66 of of IN cord-028721-x6f26ahr 4321 67 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4321 68 Yq Yq NNP cord-028721-x6f26ahr 4321 69 deletion deletion NN cord-028721-x6f26ahr 4321 70 with with IN cord-028721-x6f26ahr 4321 71 short short JJ cord-028721-x6f26ahr 4321 72 stature stature NN cord-028721-x6f26ahr 4321 73 , , , cord-028721-x6f26ahr 4321 74 abnormal abnormal JJ cord-028721-x6f26ahr 4321 75 male male JJ cord-028721-x6f26ahr 4321 76 development development NN cord-028721-x6f26ahr 4321 77 , , , cord-028721-x6f26ahr 4321 78 and and CC cord-028721-x6f26ahr 4321 79 schizoid schizoid JJ cord-028721-x6f26ahr 4321 80 character character NN cord-028721-x6f26ahr 4321 81 disorder disorder NN cord-028721-x6f26ahr 4321 82 FISH fish NN cord-028721-x6f26ahr 4321 83 characterization characterization NN cord-028721-x6f26ahr 4321 84 of of IN cord-028721-x6f26ahr 4321 85 a a DT cord-028721-x6f26ahr 4321 86 dicentric dicentric NN cord-028721-x6f26ahr 4321 87 Yq Yq NNP cord-028721-x6f26ahr 4321 88 ( ( -LRB- cord-028721-x6f26ahr 4321 89 p11.32 p11.32 NNP cord-028721-x6f26ahr 4321 90 ) ) -RRB- cord-028721-x6f26ahr 4321 91 isochromosome isochromosome NNP cord-028721-x6f26ahr 4321 92 in in IN cord-028721-x6f26ahr 4321 93 an an DT cord-028721-x6f26ahr 4321 94 azoospermic azoospermic NNP cord-028721-x6f26ahr 4321 95 male male NN cord-028721-x6f26ahr 4322 1 The the DT cord-028721-x6f26ahr 4322 2 Y Y NNP cord-028721-x6f26ahr 4322 3 chromosome chromosome NN cord-028721-x6f26ahr 4322 4 , , , cord-028721-x6f26ahr 4322 5 Part Part NNP cord-028721-x6f26ahr 4322 6 B. B. NNP cord-028721-x6f26ahr 4322 7 Clinical Clinical NNP cord-028721-x6f26ahr 4322 8 aspects aspect NNS cord-028721-x6f26ahr 4322 9 of of IN cord-028721-x6f26ahr 4322 10 Y Y NNP cord-028721-x6f26ahr 4322 11 chromosome chromosome NN cord-028721-x6f26ahr 4322 12 abnormalities abnormality NNS cord-028721-x6f26ahr 4323 1 Short short JJ cord-028721-x6f26ahr 4323 2 arm arm NN cord-028721-x6f26ahr 4323 3 dicentric dicentric NNP cord-028721-x6f26ahr 4323 4 Y Y NNP cord-028721-x6f26ahr 4323 5 chromosome chromosome NN cord-028721-x6f26ahr 4323 6 with with IN cord-028721-x6f26ahr 4323 7 associated associated JJ cord-028721-x6f26ahr 4323 8 statural statural JJ cord-028721-x6f26ahr 4323 9 defect defect NN cord-028721-x6f26ahr 4323 10 in in IN cord-028721-x6f26ahr 4323 11 a a DT cord-028721-x6f26ahr 4323 12 sterile sterile JJ cord-028721-x6f26ahr 4323 13 man man NN cord-028721-x6f26ahr 4323 14 Four four CD cord-028721-x6f26ahr 4323 15 new new JJ cord-028721-x6f26ahr 4323 16 cases case NNS cord-028721-x6f26ahr 4323 17 of of IN cord-028721-x6f26ahr 4323 18 dicentric dicentric JJ cord-028721-x6f26ahr 4323 19 Y Y NNP cord-028721-x6f26ahr 4323 20 chromosomes chromosome NNS cord-028721-x6f26ahr 4324 1 Meiotic meiotic JJ cord-028721-x6f26ahr 4324 2 studies study NNS cord-028721-x6f26ahr 4324 3 on on IN cord-028721-x6f26ahr 4324 4 a a DT cord-028721-x6f26ahr 4324 5 subfertile subfertile NN cord-028721-x6f26ahr 4324 6 patient patient JJ cord-028721-x6f26ahr 4324 7 with with IN cord-028721-x6f26ahr 4324 8 a a DT cord-028721-x6f26ahr 4324 9 ring ring NN cord-028721-x6f26ahr 4324 10 Y Y NNP cord-028721-x6f26ahr 4324 11 chromosome chromosome NN cord-028721-x6f26ahr 4324 12 Mosaic Mosaic NNP cord-028721-x6f26ahr 4324 13 ring ring NN cord-028721-x6f26ahr 4324 14 Y Y NNP cord-028721-x6f26ahr 4324 15 chromosome chromosome NN cord-028721-x6f26ahr 4324 16 in in IN cord-028721-x6f26ahr 4324 17 two two CD cord-028721-x6f26ahr 4324 18 normal normal JJ cord-028721-x6f26ahr 4324 19 healthy healthy JJ cord-028721-x6f26ahr 4324 20 men man NNS cord-028721-x6f26ahr 4324 21 with with IN cord-028721-x6f26ahr 4324 22 azoospermia azoospermia NN cord-028721-x6f26ahr 4324 23 Ring Ring NNP cord-028721-x6f26ahr 4324 24 ( ( -LRB- cord-028721-x6f26ahr 4324 25 Y Y NNP cord-028721-x6f26ahr 4324 26 ) ) -RRB- cord-028721-x6f26ahr 4324 27 in in IN cord-028721-x6f26ahr 4324 28 two two CD cord-028721-x6f26ahr 4324 29 azoospermic azoospermic JJ cord-028721-x6f26ahr 4324 30 men man NNS cord-028721-x6f26ahr 4324 31 The the DT cord-028721-x6f26ahr 4324 32 Y Y NNP cord-028721-x6f26ahr 4324 33 chromosome chromosome NN cord-028721-x6f26ahr 4324 34 Part part NN cord-028721-x6f26ahr 4324 35 B B NNP cord-028721-x6f26ahr 4324 36 : : : cord-028721-x6f26ahr 4324 37 Clinical clinical JJ cord-028721-x6f26ahr 4324 38 aspects aspect NNS cord-028721-x6f26ahr 4324 39 of of IN cord-028721-x6f26ahr 4324 40 Y Y NNP cord-028721-x6f26ahr 4324 41 chromosome chromosome NN cord-028721-x6f26ahr 4324 42 abnormalities abnormality NNS cord-028721-x6f26ahr 4325 1 An an DT cord-028721-x6f26ahr 4325 2 abnormal abnormal JJ cord-028721-x6f26ahr 4325 3 terminal terminal NN cord-028721-x6f26ahr 4325 4 X x NN cord-028721-x6f26ahr 4325 5 - - NNP cord-028721-x6f26ahr 4325 6 Y Y NNP cord-028721-x6f26ahr 4325 7 interchange interchange NN cord-028721-x6f26ahr 4325 8 accounts account VBZ cord-028721-x6f26ahr 4325 9 for for IN cord-028721-x6f26ahr 4325 10 most most JJS cord-028721-x6f26ahr 4325 11 but but CC cord-028721-x6f26ahr 4326 1 not not RB cord-028721-x6f26ahr 4326 2 all all DT cord-028721-x6f26ahr 4326 3 cases case NNS cord-028721-x6f26ahr 4326 4 of of IN cord-028721-x6f26ahr 4326 5 human human JJ cord-028721-x6f26ahr 4326 6 XX xx NN cord-028721-x6f26ahr 4326 7 maleness maleness NN cord-028721-x6f26ahr 4326 8 Cytogenetic Cytogenetic NNP cord-028721-x6f26ahr 4326 9 , , , cord-028721-x6f26ahr 4326 10 molecular molecular JJ cord-028721-x6f26ahr 4326 11 and and CC cord-028721-x6f26ahr 4326 12 testicular testicular JJ cord-028721-x6f26ahr 4326 13 tissue tissue NN cord-028721-x6f26ahr 4326 14 studies study NNS cord-028721-x6f26ahr 4326 15 in in IN cord-028721-x6f26ahr 4326 16 an an DT cord-028721-x6f26ahr 4326 17 infertile infertile JJ cord-028721-x6f26ahr 4326 18 45,X 45,x CD cord-028721-x6f26ahr 4326 19 male male JJ cord-028721-x6f26ahr 4326 20 carrying carry VBG cord-028721-x6f26ahr 4326 21 an an DT cord-028721-x6f26ahr 4326 22 unbalanced unbalanced JJ cord-028721-x6f26ahr 4326 23 ( ( -LRB- cord-028721-x6f26ahr 4326 24 Y y NN cord-028721-x6f26ahr 4326 25 ; ; : cord-028721-x6f26ahr 4326 26 22 22 CD cord-028721-x6f26ahr 4326 27 ) ) -RRB- cord-028721-x6f26ahr 4326 28 translocation translocation NN cord-028721-x6f26ahr 4326 29 : : : cord-028721-x6f26ahr 4326 30 case case NN cord-028721-x6f26ahr 4326 31 report report NN cord-028721-x6f26ahr 4326 32 Unique Unique NNP cord-028721-x6f26ahr 4326 33 t(Y t(y NN cord-028721-x6f26ahr 4326 34 ; ; : cord-028721-x6f26ahr 4326 35 1)(q12 1)(q12 CD cord-028721-x6f26ahr 4326 36 ; ; : cord-028721-x6f26ahr 4326 37 q12 q12 NN cord-028721-x6f26ahr 4326 38 ) ) -RRB- cord-028721-x6f26ahr 4326 39 reciprocal reciprocal JJ cord-028721-x6f26ahr 4326 40 translocation translocation NN cord-028721-x6f26ahr 4326 41 with with IN cord-028721-x6f26ahr 4326 42 loss loss NN cord-028721-x6f26ahr 4326 43 of of IN cord-028721-x6f26ahr 4326 44 the the DT cord-028721-x6f26ahr 4326 45 heterochromatic heterochromatic JJ cord-028721-x6f26ahr 4326 46 region region NN cord-028721-x6f26ahr 4326 47 of of IN cord-028721-x6f26ahr 4326 48 chromosome chromosome NN cord-028721-x6f26ahr 4326 49 1 1 CD cord-028721-x6f26ahr 4326 50 in in IN cord-028721-x6f26ahr 4326 51 a a DT cord-028721-x6f26ahr 4326 52 male male NN cord-028721-x6f26ahr 4326 53 with with IN cord-028721-x6f26ahr 4326 54 azoospermia azoospermia NN cord-028721-x6f26ahr 4326 55 due due IN cord-028721-x6f26ahr 4326 56 to to IN cord-028721-x6f26ahr 4326 57 meiotic meiotic JJ cord-028721-x6f26ahr 4326 58 arrest arrest NN cord-028721-x6f26ahr 4326 59 : : : cord-028721-x6f26ahr 4326 60 a a DT cord-028721-x6f26ahr 4326 61 case case NN cord-028721-x6f26ahr 4326 62 report report NN cord-028721-x6f26ahr 4326 63 Y Y NNP cord-028721-x6f26ahr 4326 64 ; ; : cord-028721-x6f26ahr 4326 65 autosome autosome NN cord-028721-x6f26ahr 4326 66 translocations translocation NNS cord-028721-x6f26ahr 4326 67 and and CC cord-028721-x6f26ahr 4326 68 mosaicism mosaicism NN cord-028721-x6f26ahr 4326 69 in in IN cord-028721-x6f26ahr 4326 70 the the DT cord-028721-x6f26ahr 4326 71 aetiology aetiology NN cord-028721-x6f26ahr 4326 72 of of IN cord-028721-x6f26ahr 4326 73 45,X 45,x CD cord-028721-x6f26ahr 4326 74 maleness maleness NN cord-028721-x6f26ahr 4326 75 : : : cord-028721-x6f26ahr 4326 76 assignment assignment NN cord-028721-x6f26ahr 4326 77 of of IN cord-028721-x6f26ahr 4326 78 fertility fertility NN cord-028721-x6f26ahr 4326 79 factor factor NN cord-028721-x6f26ahr 4326 80 to to IN cord-028721-x6f26ahr 4326 81 distal distal JJ cord-028721-x6f26ahr 4326 82 Yq Yq NNP cord-028721-x6f26ahr 4327 1 ll will UH cord-028721-x6f26ahr 4327 2 Characterization characterization NN cord-028721-x6f26ahr 4327 3 of of IN cord-028721-x6f26ahr 4327 4 a a DT cord-028721-x6f26ahr 4327 5 ( ( -LRB- cord-028721-x6f26ahr 4327 6 Y y NN cord-028721-x6f26ahr 4327 7 ; ; : cord-028721-x6f26ahr 4327 8 4 4 CD cord-028721-x6f26ahr 4327 9 ) ) -RRB- cord-028721-x6f26ahr 4327 10 translocation translocation NN cord-028721-x6f26ahr 4327 11 by by IN cord-028721-x6f26ahr 4327 12 DNA dna NN cord-028721-x6f26ahr 4327 13 hybridization hybridization NN cord-028721-x6f26ahr 4327 14 Genome Genome NNP cord-028721-x6f26ahr 4327 15 analysis analysis NN cord-028721-x6f26ahr 4327 16 : : : cord-028721-x6f26ahr 4328 1 From from IN cord-028721-x6f26ahr 4328 2 sequence sequence NN cord-028721-x6f26ahr 4328 3 to to TO cord-028721-x6f26ahr 4328 4 function function VB cord-028721-x6f26ahr 4328 5 Submicroscopic submicroscopic JJ cord-028721-x6f26ahr 4328 6 delections delection NNS cord-028721-x6f26ahr 4328 7 in in IN cord-028721-x6f26ahr 4328 8 the the DT cord-028721-x6f26ahr 4328 9 Y Y NNP cord-028721-x6f26ahr 4328 10 chromosome chromosome NN cord-028721-x6f26ahr 4328 11 of of IN cord-028721-x6f26ahr 4328 12 infertile infertile JJ cord-028721-x6f26ahr 4328 13 men man NNS cord-028721-x6f26ahr 4328 14 Y y NN cord-028721-x6f26ahr 4328 15 - - HYPH cord-028721-x6f26ahr 4328 16 chromosome chromosome NN cord-028721-x6f26ahr 4328 17 deletions deletion NNS cord-028721-x6f26ahr 4328 18 in in IN cord-028721-x6f26ahr 4328 19 idiopathic idiopathic JJ cord-028721-x6f26ahr 4328 20 severe severe JJ cord-028721-x6f26ahr 4328 21 testiculopathies testiculopathie NNS cord-028721-x6f26ahr 4328 22 Prevalence prevalence NN cord-028721-x6f26ahr 4328 23 of of IN cord-028721-x6f26ahr 4328 24 Y Y NNP cord-028721-x6f26ahr 4328 25 chromosome chromosome NN cord-028721-x6f26ahr 4328 26 microdelections microdelection NNS cord-028721-x6f26ahr 4328 27 in in IN cord-028721-x6f26ahr 4328 28 oligospermic oligospermic NNP cord-028721-x6f26ahr 4328 29 and and CC cord-028721-x6f26ahr 4328 30 azoospermic azoospermic NNP cord-028721-x6f26ahr 4328 31 candidates candidate NNS cord-028721-x6f26ahr 4328 32 for for IN cord-028721-x6f26ahr 4328 33 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 4328 34 sperm sperm NN cord-028721-x6f26ahr 4328 35 injection injection NN cord-028721-x6f26ahr 4328 36 Y Y NNP cord-028721-x6f26ahr 4328 37 - - HYPH cord-028721-x6f26ahr 4328 38 chromosome chromosome NN cord-028721-x6f26ahr 4328 39 microdeletions microdeletion NNS cord-028721-x6f26ahr 4328 40 and and CC cord-028721-x6f26ahr 4328 41 recurrent recurrent JJ cord-028721-x6f26ahr 4328 42 pregnancy pregnancy NN cord-028721-x6f26ahr 4328 43 loss loss NN cord-028721-x6f26ahr 4328 44 Molecular molecular JJ cord-028721-x6f26ahr 4328 45 scanning scanning NN cord-028721-x6f26ahr 4328 46 of of IN cord-028721-x6f26ahr 4328 47 Yq Yq NNP cord-028721-x6f26ahr 4328 48 11 11 CD cord-028721-x6f26ahr 4328 49 ( ( -LRB- cord-028721-x6f26ahr 4328 50 interval interval NN cord-028721-x6f26ahr 4328 51 6 6 CD cord-028721-x6f26ahr 4328 52 ) ) -RRB- cord-028721-x6f26ahr 4328 53 in in IN cord-028721-x6f26ahr 4328 54 men man NNS cord-028721-x6f26ahr 4328 55 with with IN cord-028721-x6f26ahr 4328 56 Sertoli Sertoli NNP cord-028721-x6f26ahr 4328 57 - - HYPH cord-028721-x6f26ahr 4328 58 cellonly cellonly NN cord-028721-x6f26ahr 4328 59 syndrome syndrome NN cord-028721-x6f26ahr 4328 60 Y Y NNP cord-028721-x6f26ahr 4328 61 chromosome chromosome NN cord-028721-x6f26ahr 4328 62 variants variant NNS cord-028721-x6f26ahr 4328 63 and and CC cord-028721-x6f26ahr 4328 64 male male JJ cord-028721-x6f26ahr 4328 65 reproductive reproductive JJ cord-028721-x6f26ahr 4328 66 function function NN cord-028721-x6f26ahr 4329 1 A a DT cord-028721-x6f26ahr 4329 2 duplication duplication NN cord-028721-x6f26ahr 4329 3 of of IN cord-028721-x6f26ahr 4329 4 distal distal JJ cord-028721-x6f26ahr 4329 5 Xp Xp NNP cord-028721-x6f26ahr 4329 6 associated associate VBN cord-028721-x6f26ahr 4329 7 with with IN cord-028721-x6f26ahr 4329 8 hypogonadotrophic hypogonadotrophic JJ cord-028721-x6f26ahr 4329 9 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4329 10 , , , cord-028721-x6f26ahr 4329 11 hypoplastic hypoplastic JJ cord-028721-x6f26ahr 4329 12 external external JJ cord-028721-x6f26ahr 4329 13 genitalia genitalia NNS cord-028721-x6f26ahr 4329 14 , , , cord-028721-x6f26ahr 4329 15 mental mental JJ cord-028721-x6f26ahr 4329 16 retardation retardation NN cord-028721-x6f26ahr 4329 17 , , , cord-028721-x6f26ahr 4329 18 and and CC cord-028721-x6f26ahr 4329 19 multiple multiple JJ cord-028721-x6f26ahr 4329 20 congenital congenital JJ cord-028721-x6f26ahr 4329 21 abnormalities abnormality NNS cord-028721-x6f26ahr 4330 1 The the DT cord-028721-x6f26ahr 4330 2 behavior behavior NN cord-028721-x6f26ahr 4330 3 of of IN cord-028721-x6f26ahr 4330 4 sex sex NN cord-028721-x6f26ahr 4330 5 chromosomes chromosome NNS cord-028721-x6f26ahr 4330 6 in in IN cord-028721-x6f26ahr 4330 7 two two CD cord-028721-x6f26ahr 4330 8 human human NN cord-028721-x6f26ahr 4330 9 Xautosome Xautosome NNP cord-028721-x6f26ahr 4330 10 translocations translocation NNS cord-028721-x6f26ahr 4330 11 : : : cord-028721-x6f26ahr 4330 12 failure failure NN cord-028721-x6f26ahr 4330 13 of of IN cord-028721-x6f26ahr 4330 14 extensive extensive JJ cord-028721-x6f26ahr 4330 15 -inactivation -inactivation NN cord-028721-x6f26ahr 4330 16 spreading spread VBG cord-028721-x6f26ahr 4330 17 ICSI ICSI NNP cord-028721-x6f26ahr 4330 18 and and CC cord-028721-x6f26ahr 4330 19 the the DT cord-028721-x6f26ahr 4330 20 transmission transmission NN cord-028721-x6f26ahr 4330 21 of of IN cord-028721-x6f26ahr 4330 22 Xautosomal Xautosomal NNP cord-028721-x6f26ahr 4330 23 translocation translocation NN cord-028721-x6f26ahr 4330 24 : : : cord-028721-x6f26ahr 4330 25 a a DT cord-028721-x6f26ahr 4330 26 threegeneration threegeneration NN cord-028721-x6f26ahr 4330 27 evaluation evaluation NN cord-028721-x6f26ahr 4330 28 of of IN cord-028721-x6f26ahr 4330 29 X x NN cord-028721-x6f26ahr 4330 30 ; ; : cord-028721-x6f26ahr 4330 31 20 20 CD cord-028721-x6f26ahr 4330 32 translocation translocation NN cord-028721-x6f26ahr 4330 33 : : : cord-028721-x6f26ahr 4330 34 case case NN cord-028721-x6f26ahr 4330 35 report report NN cord-028721-x6f26ahr 4330 36 XXX XXX NNP cord-028721-x6f26ahr 4330 37 male male NNP cord-028721-x6f26ahr 4330 38 : : : cord-028721-x6f26ahr 4330 39 a a DT cord-028721-x6f26ahr 4330 40 clinical clinical JJ cord-028721-x6f26ahr 4330 41 and and CC cord-028721-x6f26ahr 4330 42 molecular molecular JJ cord-028721-x6f26ahr 4330 43 study study NN cord-028721-x6f26ahr 4330 44 Chromosome Chromosome NNP cord-028721-x6f26ahr 4330 45 complements complement VBZ cord-028721-x6f26ahr 4330 46 in in IN cord-028721-x6f26ahr 4330 47 695 695 CD cord-028721-x6f26ahr 4330 48 sperm sperm NN cord-028721-x6f26ahr 4330 49 from from IN cord-028721-x6f26ahr 4330 50 three three CD cord-028721-x6f26ahr 4330 51 men man NNS cord-028721-x6f26ahr 4330 52 heterozygous heterozygous JJ cord-028721-x6f26ahr 4330 53 for for IN cord-028721-x6f26ahr 4330 54 reciprocal reciprocal JJ cord-028721-x6f26ahr 4330 55 translocations translocation NNS cord-028721-x6f26ahr 4330 56 and and CC cord-028721-x6f26ahr 4330 57 a a DT cord-028721-x6f26ahr 4330 58 review review NN cord-028721-x6f26ahr 4330 59 of of IN cord-028721-x6f26ahr 4330 60 the the DT cord-028721-x6f26ahr 4330 61 literature literature NN cord-028721-x6f26ahr 4330 62 Analysis Analysis NNP cord-028721-x6f26ahr 4330 63 of of IN cord-028721-x6f26ahr 4330 64 sperm sperm NN cord-028721-x6f26ahr 4330 65 chromosome chromosome NN cord-028721-x6f26ahr 4330 66 complements complement VBZ cord-028721-x6f26ahr 4330 67 from from IN cord-028721-x6f26ahr 4330 68 a a DT cord-028721-x6f26ahr 4330 69 man man NN cord-028721-x6f26ahr 4330 70 heterozygous heterozygous JJ cord-028721-x6f26ahr 4330 71 for for IN cord-028721-x6f26ahr 4330 72 a a DT cord-028721-x6f26ahr 4330 73 pericentric pericentric JJ cord-028721-x6f26ahr 4330 74 inversion inversion NN cord-028721-x6f26ahr 4330 75 of of IN cord-028721-x6f26ahr 4330 76 chromosome chromosome NN cord-028721-x6f26ahr 4330 77 1 1 CD cord-028721-x6f26ahr 4331 1 An an DT cord-028721-x6f26ahr 4331 2 excess excess NN cord-028721-x6f26ahr 4331 3 of of IN cord-028721-x6f26ahr 4331 4 chromosome chromosome NN cord-028721-x6f26ahr 4331 5 1 1 CD cord-028721-x6f26ahr 4331 6 breakpoints breakpoint NNS cord-028721-x6f26ahr 4331 7 in in IN cord-028721-x6f26ahr 4331 8 male male JJ cord-028721-x6f26ahr 4331 9 infertility infertility NN cord-028721-x6f26ahr 4331 10 Unbalanced unbalanced JJ cord-028721-x6f26ahr 4331 11 chromosomal chromosomal JJ cord-028721-x6f26ahr 4331 12 translocation translocation NN cord-028721-x6f26ahr 4331 13 associated associate VBN cord-028721-x6f26ahr 4331 14 with with IN cord-028721-x6f26ahr 4331 15 Sertoli Sertoli NNP cord-028721-x6f26ahr 4331 16 - - HYPH cord-028721-x6f26ahr 4331 17 cell cell NN cord-028721-x6f26ahr 4331 18 - - HYPH cord-028721-x6f26ahr 4331 19 only only RB cord-028721-x6f26ahr 4331 20 histology histology NN cord-028721-x6f26ahr 4331 21 Urological urological JJ cord-028721-x6f26ahr 4331 22 manifestations manifestation NNS cord-028721-x6f26ahr 4331 23 of of IN cord-028721-x6f26ahr 4331 24 Down Down NNP cord-028721-x6f26ahr 4331 25 syndrome syndrome NN cord-028721-x6f26ahr 4331 26 Hormone hormone NN cord-028721-x6f26ahr 4331 27 profi profi NNP cord-028721-x6f26ahr 4331 28 les les NNP cord-028721-x6f26ahr 4331 29 and and CC cord-028721-x6f26ahr 4331 30 contralateral contralateral JJ cord-028721-x6f26ahr 4331 31 testicular testicular JJ cord-028721-x6f26ahr 4331 32 histology histology NN cord-028721-x6f26ahr 4331 33 in in IN cord-028721-x6f26ahr 4331 34 Down Down NNP cord-028721-x6f26ahr 4331 35 's 's POS cord-028721-x6f26ahr 4331 36 syndrome syndrome NN cord-028721-x6f26ahr 4331 37 with with IN cord-028721-x6f26ahr 4331 38 unilateral unilateral JJ cord-028721-x6f26ahr 4331 39 testicular testicular NNP cord-028721-x6f26ahr 4331 40 tumor tumor NN cord-028721-x6f26ahr 4332 1 Down down IN cord-028721-x6f26ahr 4332 2 syndrome syndrome NN cord-028721-x6f26ahr 4332 3 and and CC cord-028721-x6f26ahr 4332 4 male male JJ cord-028721-x6f26ahr 4332 5 fertility fertility NN cord-028721-x6f26ahr 4332 6 : : : cord-028721-x6f26ahr 4332 7 PCR pcr NN cord-028721-x6f26ahr 4332 8 - - HYPH cord-028721-x6f26ahr 4332 9 derived derive VBN cord-028721-x6f26ahr 4332 10 fi fi NNP cord-028721-x6f26ahr 4332 11 ngerprinting ngerprinting NN cord-028721-x6f26ahr 4332 12 , , , cord-028721-x6f26ahr 4332 13 serological serological JJ cord-028721-x6f26ahr 4332 14 and and CC cord-028721-x6f26ahr 4332 15 andrological andrological JJ cord-028721-x6f26ahr 4332 16 investigations investigation NNS cord-028721-x6f26ahr 4333 1 Successful successful JJ cord-028721-x6f26ahr 4333 2 pregnancy pregnancy NN cord-028721-x6f26ahr 4333 3 and and CC cord-028721-x6f26ahr 4333 4 delivery delivery NN cord-028721-x6f26ahr 4333 5 from from IN cord-028721-x6f26ahr 4333 6 frozen freeze VBN cord-028721-x6f26ahr 4333 7 - - HYPH cord-028721-x6f26ahr 4333 8 thawed thaw VBN cord-028721-x6f26ahr 4333 9 embryos embryo NNS cord-028721-x6f26ahr 4333 10 after after IN cord-028721-x6f26ahr 4333 11 intracytoplasmic intracytoplasmic JJ cord-028721-x6f26ahr 4333 12 sperm sperm NN cord-028721-x6f26ahr 4333 13 injection injection NN cord-028721-x6f26ahr 4333 14 using use VBG cord-028721-x6f26ahr 4333 15 round round RB cord-028721-x6f26ahr 4333 16 - - HYPH cord-028721-x6f26ahr 4333 17 headed headed JJ cord-028721-x6f26ahr 4333 18 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4333 19 and and CC cord-028721-x6f26ahr 4333 20 assisted assisted JJ cord-028721-x6f26ahr 4333 21 oocyte oocyte NN cord-028721-x6f26ahr 4333 22 activation activation NN cord-028721-x6f26ahr 4333 23 in in IN cord-028721-x6f26ahr 4333 24 a a DT cord-028721-x6f26ahr 4333 25 globozoospermic globozoospermic JJ cord-028721-x6f26ahr 4333 26 patient patient NN cord-028721-x6f26ahr 4333 27 with with IN cord-028721-x6f26ahr 4333 28 mosaic mosaic JJ cord-028721-x6f26ahr 4333 29 Down Down NNP cord-028721-x6f26ahr 4333 30 syndrome syndrome NN cord-028721-x6f26ahr 4333 31 Maturation maturation NN cord-028721-x6f26ahr 4333 32 delay delay NN cord-028721-x6f26ahr 4333 33 of of IN cord-028721-x6f26ahr 4333 34 germ germ NN cord-028721-x6f26ahr 4333 35 cells cell NNS cord-028721-x6f26ahr 4333 36 in in IN cord-028721-x6f26ahr 4333 37 fetuses fetus NNS cord-028721-x6f26ahr 4333 38 with with IN cord-028721-x6f26ahr 4333 39 trisomy trisomy NN cord-028721-x6f26ahr 4333 40 21 21 CD cord-028721-x6f26ahr 4333 41 results result NNS cord-028721-x6f26ahr 4333 42 in in IN cord-028721-x6f26ahr 4333 43 increased increase VBN cord-028721-x6f26ahr 4333 44 risk risk NN cord-028721-x6f26ahr 4333 45 for for IN cord-028721-x6f26ahr 4333 46 the the DT cord-028721-x6f26ahr 4333 47 development development NN cord-028721-x6f26ahr 4333 48 of of IN cord-028721-x6f26ahr 4333 49 testicular testicular JJ cord-028721-x6f26ahr 4333 50 germ germ NN cord-028721-x6f26ahr 4333 51 cell cell NN cord-028721-x6f26ahr 4333 52 tumors tumor NNS cord-028721-x6f26ahr 4333 53 Down down IN cord-028721-x6f26ahr 4333 54 syndrome syndrome NN cord-028721-x6f26ahr 4333 55 in in IN cord-028721-x6f26ahr 4333 56 the the DT cord-028721-x6f26ahr 4333 57 male male NN cord-028721-x6f26ahr 4333 58 . . . cord-028721-x6f26ahr 4334 1 Reproductive reproductive JJ cord-028721-x6f26ahr 4334 2 pathology pathology NN cord-028721-x6f26ahr 4334 3 and and CC cord-028721-x6f26ahr 4334 4 meiotic meiotic JJ cord-028721-x6f26ahr 4334 5 studies study NNS cord-028721-x6f26ahr 4334 6 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 4334 7 due due JJ cord-028721-x6f26ahr 4334 8 to to IN cord-028721-x6f26ahr 4334 9 primary primary JJ cord-028721-x6f26ahr 4334 10 testicular testicular JJ cord-028721-x6f26ahr 4334 11 failure failure NN cord-028721-x6f26ahr 4334 12 Correlation Correlation NNP cord-028721-x6f26ahr 4334 13 between between IN cord-028721-x6f26ahr 4334 14 CTG CTG NNP cord-028721-x6f26ahr 4334 15 trinucleotide trinucleotide NNP cord-028721-x6f26ahr 4334 16 repeat repeat NN cord-028721-x6f26ahr 4334 17 length length NN cord-028721-x6f26ahr 4334 18 and and CC cord-028721-x6f26ahr 4334 19 frequency frequency NN cord-028721-x6f26ahr 4334 20 of of IN cord-028721-x6f26ahr 4334 21 severe severe JJ cord-028721-x6f26ahr 4334 22 congenital congenital JJ cord-028721-x6f26ahr 4334 23 myotonic myotonic JJ cord-028721-x6f26ahr 4334 24 dystrophy dystrophy NN cord-028721-x6f26ahr 4334 25 Size size NN cord-028721-x6f26ahr 4334 26 of of IN cord-028721-x6f26ahr 4334 27 the the DT cord-028721-x6f26ahr 4334 28 unstable unstable JJ cord-028721-x6f26ahr 4334 29 CTG CTG NNP cord-028721-x6f26ahr 4334 30 repeat repeat NN cord-028721-x6f26ahr 4334 31 sequence sequence NN cord-028721-x6f26ahr 4334 32 in in IN cord-028721-x6f26ahr 4334 33 relation relation NN cord-028721-x6f26ahr 4334 34 to to IN cord-028721-x6f26ahr 4334 35 phenotype phenotype NN cord-028721-x6f26ahr 4334 36 and and CC cord-028721-x6f26ahr 4334 37 prenatal prenatal JJ cord-028721-x6f26ahr 4334 38 transmission transmission NN cord-028721-x6f26ahr 4334 39 in in IN cord-028721-x6f26ahr 4334 40 myotonic myotonic JJ cord-028721-x6f26ahr 4334 41 dystrophy dystrophy NN cord-028721-x6f26ahr 4334 42 Relationship Relationship NNP cord-028721-x6f26ahr 4334 43 between between IN cord-028721-x6f26ahr 4334 44 parenteral parenteral JJ cord-028721-x6f26ahr 4334 45 trinucleotide trinucleotide JJ cord-028721-x6f26ahr 4334 46 CTG CTG NNP cord-028721-x6f26ahr 4334 47 repeat repeat NN cord-028721-x6f26ahr 4334 48 length length NN cord-028721-x6f26ahr 4334 49 and and CC cord-028721-x6f26ahr 4334 50 severity severity NN cord-028721-x6f26ahr 4334 51 of of IN cord-028721-x6f26ahr 4334 52 myotonic myotonic JJ cord-028721-x6f26ahr 4334 53 dystrophy dystrophy NN cord-028721-x6f26ahr 4334 54 in in IN cord-028721-x6f26ahr 4334 55 offspring offspre VBG cord-028721-x6f26ahr 4334 56 Myotonic myotonic JJ cord-028721-x6f26ahr 4334 57 dystrophy dystrophy NN cord-028721-x6f26ahr 4334 58 : : : cord-028721-x6f26ahr 4335 1 clinical clinical JJ cord-028721-x6f26ahr 4335 2 and and CC cord-028721-x6f26ahr 4335 3 molecular molecular JJ cord-028721-x6f26ahr 4335 4 parallels parallel NNS cord-028721-x6f26ahr 4335 5 between between IN cord-028721-x6f26ahr 4335 6 myotonic myotonic JJ cord-028721-x6f26ahr 4335 7 dystrophy dystrophy NN cord-028721-x6f26ahr 4335 8 type type NN cord-028721-x6f26ahr 4335 9 1 1 CD cord-028721-x6f26ahr 4335 10 and and CC cord-028721-x6f26ahr 4335 11 type type NN cord-028721-x6f26ahr 4335 12 2 2 CD cord-028721-x6f26ahr 4335 13 Infl Infl NNP cord-028721-x6f26ahr 4335 14 uence uence NN cord-028721-x6f26ahr 4335 15 of of IN cord-028721-x6f26ahr 4335 16 sex sex NN cord-028721-x6f26ahr 4335 17 of of IN cord-028721-x6f26ahr 4335 18 the the DT cord-028721-x6f26ahr 4335 19 transmitting transmit VBG cord-028721-x6f26ahr 4335 20 parent parent NN cord-028721-x6f26ahr 4335 21 as as RB cord-028721-x6f26ahr 4335 22 well well RB cord-028721-x6f26ahr 4335 23 as as IN cord-028721-x6f26ahr 4335 24 of of IN cord-028721-x6f26ahr 4335 25 parental parental JJ cord-028721-x6f26ahr 4335 26 allele allele NN cord-028721-x6f26ahr 4335 27 size size NN cord-028721-x6f26ahr 4335 28 on on IN cord-028721-x6f26ahr 4335 29 the the DT cord-028721-x6f26ahr 4335 30 CTG CTG NNP cord-028721-x6f26ahr 4335 31 expansion expansion NN cord-028721-x6f26ahr 4335 32 in in IN cord-028721-x6f26ahr 4335 33 myotonic myotonic JJ cord-028721-x6f26ahr 4335 34 dystrophy dystrophy NN cord-028721-x6f26ahr 4335 35 ( ( -LRB- cord-028721-x6f26ahr 4335 36 DM DM NNP cord-028721-x6f26ahr 4335 37 ) ) -RRB- cord-028721-x6f26ahr 4335 38 CTG CTG NNP cord-028721-x6f26ahr 4335 39 amplifi amplifi NNP cord-028721-x6f26ahr 4335 40 cation cation NN cord-028721-x6f26ahr 4335 41 in in IN cord-028721-x6f26ahr 4335 42 the the DT cord-028721-x6f26ahr 4335 43 DM1PK DM1PK NNP cord-028721-x6f26ahr 4335 44 gene gene NN cord-028721-x6f26ahr 4335 45 is be VBZ cord-028721-x6f26ahr 4335 46 not not RB cord-028721-x6f26ahr 4335 47 associated associate VBN cord-028721-x6f26ahr 4335 48 with with IN cord-028721-x6f26ahr 4335 49 idiopathic idiopathic JJ cord-028721-x6f26ahr 4335 50 male male JJ cord-028721-x6f26ahr 4335 51 subfertility subfertility NN cord-028721-x6f26ahr 4335 52 Correlations correlation NNS cord-028721-x6f26ahr 4335 53 between between IN cord-028721-x6f26ahr 4335 54 individual individual JJ cord-028721-x6f26ahr 4335 55 clinical clinical JJ cord-028721-x6f26ahr 4335 56 manifestations manifestation NNS cord-028721-x6f26ahr 4335 57 and and CC cord-028721-x6f26ahr 4335 58 CTG CTG NNP cord-028721-x6f26ahr 4335 59 repeat repeat VB cord-028721-x6f26ahr 4335 60 amplifi amplifi NNP cord-028721-x6f26ahr 4335 61 cation cation NN cord-028721-x6f26ahr 4335 62 in in IN cord-028721-x6f26ahr 4335 63 myotonic myotonic JJ cord-028721-x6f26ahr 4335 64 dystrophy dystrophy NN cord-028721-x6f26ahr 4335 65 Increasing increase VBG cord-028721-x6f26ahr 4335 66 infertility infertility NN cord-028721-x6f26ahr 4335 67 in in IN cord-028721-x6f26ahr 4335 68 myotonia myotonia NN cord-028721-x6f26ahr 4335 69 dystrophica dystrophica NNP cord-028721-x6f26ahr 4335 70 Curschmann Curschmann NNP cord-028721-x6f26ahr 4335 71 - - HYPH cord-028721-x6f26ahr 4335 72 Steinert Steinert NNP cord-028721-x6f26ahr 4335 73 . . . cord-028721-x6f26ahr 4336 1 A a DT cord-028721-x6f26ahr 4336 2 case case NN cord-028721-x6f26ahr 4336 3 report report NN cord-028721-x6f26ahr 4336 4 Dystrophin Dystrophin NNP cord-028721-x6f26ahr 4336 5 characterization characterization NN cord-028721-x6f26ahr 4336 6 in in IN cord-028721-x6f26ahr 4336 7 muscle muscle NN cord-028721-x6f26ahr 4336 8 biopsies biopsy NNS cord-028721-x6f26ahr 4336 9 from from IN cord-028721-x6f26ahr 4336 10 Duchenne Duchenne NNP cord-028721-x6f26ahr 4336 11 and and CC cord-028721-x6f26ahr 4336 12 Becker Becker NNP cord-028721-x6f26ahr 4336 13 muscular muscular JJ cord-028721-x6f26ahr 4336 14 dystrophy dystrophy NN cord-028721-x6f26ahr 4336 15 patients patient NNS cord-028721-x6f26ahr 4336 16 Dystrophin Dystrophin NNP cord-028721-x6f26ahr 4336 17 , , , cord-028721-x6f26ahr 4336 18 its -PRON- PRP$ cord-028721-x6f26ahr 4336 19 interactions interaction NNS cord-028721-x6f26ahr 4336 20 with with IN cord-028721-x6f26ahr 4336 21 other other JJ cord-028721-x6f26ahr 4336 22 proteins protein NNS cord-028721-x6f26ahr 4336 23 , , , cord-028721-x6f26ahr 4336 24 and and CC cord-028721-x6f26ahr 4336 25 implications implication NNS cord-028721-x6f26ahr 4336 26 for for IN cord-028721-x6f26ahr 4336 27 muscular muscular JJ cord-028721-x6f26ahr 4336 28 dystrophy dystrophy NN cord-028721-x6f26ahr 4336 29 Cloning cloning NN cord-028721-x6f26ahr 4336 30 of of IN cord-028721-x6f26ahr 4336 31 two two CD cord-028721-x6f26ahr 4336 32 new new JJ cord-028721-x6f26ahr 4336 33 human human JJ cord-028721-x6f26ahr 4336 34 helicase helicase NN cord-028721-x6f26ahr 4336 35 genes gene NNS cord-028721-x6f26ahr 4336 36 of of IN cord-028721-x6f26ahr 4336 37 the the DT cord-028721-x6f26ahr 4336 38 RECQ RECQ NNP cord-028721-x6f26ahr 4336 39 family family NN cord-028721-x6f26ahr 4336 40 : : : cord-028721-x6f26ahr 4336 41 biological biological JJ cord-028721-x6f26ahr 4336 42 signifi signifi NNP cord-028721-x6f26ahr 4336 43 cance cance NN cord-028721-x6f26ahr 4336 44 of of IN cord-028721-x6f26ahr 4336 45 multiple multiple JJ cord-028721-x6f26ahr 4336 46 species specie NNS cord-028721-x6f26ahr 4336 47 in in IN cord-028721-x6f26ahr 4336 48 higher high JJR cord-028721-x6f26ahr 4336 49 eukaryotes eukaryote NNS cord-028721-x6f26ahr 4336 50 Positional positional JJ cord-028721-x6f26ahr 4336 51 cloning cloning NN cord-028721-x6f26ahr 4336 52 of of IN cord-028721-x6f26ahr 4336 53 the the DT cord-028721-x6f26ahr 4336 54 Werner Werner NNP cord-028721-x6f26ahr 4336 55 's 's POS cord-028721-x6f26ahr 4336 56 syndrome syndrome NN cord-028721-x6f26ahr 4336 57 gene gene NN cord-028721-x6f26ahr 4336 58 Chromosomal chromosomal JJ cord-028721-x6f26ahr 4336 59 breakage breakage NN cord-028721-x6f26ahr 4336 60 in in IN cord-028721-x6f26ahr 4336 61 human human JJ cord-028721-x6f26ahr 4336 62 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4336 63 , , , cord-028721-x6f26ahr 4336 64 a a DT cord-028721-x6f26ahr 4336 65 heterozygous heterozygous JJ cord-028721-x6f26ahr 4336 66 effect effect NN cord-028721-x6f26ahr 4336 67 of of IN cord-028721-x6f26ahr 4336 68 the the DT cord-028721-x6f26ahr 4336 69 Bloom Bloom NNP cord-028721-x6f26ahr 4336 70 syndrome syndrome NN cord-028721-x6f26ahr 4336 71 mutation mutation NN cord-028721-x6f26ahr 4336 72 RECQL4-defi RECQL4-defi NNP cord-028721-x6f26ahr 4336 73 cient cient NN cord-028721-x6f26ahr 4336 74 cells cell NNS cord-028721-x6f26ahr 4336 75 are be VBP cord-028721-x6f26ahr 4336 76 hypersensitive hypersensitive JJ cord-028721-x6f26ahr 4336 77 to to IN cord-028721-x6f26ahr 4336 78 oxidative oxidative JJ cord-028721-x6f26ahr 4336 79 stress/ stress/ CD cord-028721-x6f26ahr 4336 80 damage damage NN cord-028721-x6f26ahr 4336 81 : : : cord-028721-x6f26ahr 4337 1 Insights insight NNS cord-028721-x6f26ahr 4337 2 for for IN cord-028721-x6f26ahr 4337 3 osteosarcoma osteosarcoma NN cord-028721-x6f26ahr 4337 4 prevalence prevalence NN cord-028721-x6f26ahr 4337 5 and and CC cord-028721-x6f26ahr 4337 6 heterogeneity heterogeneity NN cord-028721-x6f26ahr 4337 7 in in IN cord-028721-x6f26ahr 4337 8 Rothmund Rothmund NNP cord-028721-x6f26ahr 4337 9 - - HYPH cord-028721-x6f26ahr 4337 10 Thomson Thomson NNP cord-028721-x6f26ahr 4337 11 syndrome syndrome NN cord-028721-x6f26ahr 4337 12 Cockayne Cockayne NNP cord-028721-x6f26ahr 4337 13 's 's POS cord-028721-x6f26ahr 4337 14 syndrome syndrome NN cord-028721-x6f26ahr 4337 15 with with IN cord-028721-x6f26ahr 4337 16 unusual unusual JJ cord-028721-x6f26ahr 4337 17 retinal retinal JJ cord-028721-x6f26ahr 4337 18 involvement involvement NN cord-028721-x6f26ahr 4337 19 ( ( -LRB- cord-028721-x6f26ahr 4337 20 report report NN cord-028721-x6f26ahr 4337 21 of of IN cord-028721-x6f26ahr 4337 22 one one CD cord-028721-x6f26ahr 4337 23 family family NN cord-028721-x6f26ahr 4337 24 ) ) -RRB- cord-028721-x6f26ahr 4338 1 Eccrine eccrine JJ cord-028721-x6f26ahr 4338 2 sweat sweat NN cord-028721-x6f26ahr 4338 3 gland gland NN cord-028721-x6f26ahr 4338 4 anatomy anatomy NN cord-028721-x6f26ahr 4338 5 in in IN cord-028721-x6f26ahr 4338 6 cockayne cockayne NNP cord-028721-x6f26ahr 4338 7 syndrome syndrome NN cord-028721-x6f26ahr 4338 8 : : : cord-028721-x6f26ahr 4338 9 a a DT cord-028721-x6f26ahr 4338 10 possible possible JJ cord-028721-x6f26ahr 4338 11 diagnostic diagnostic JJ cord-028721-x6f26ahr 4338 12 aid aid NN cord-028721-x6f26ahr 4338 13 Cockayne Cockayne NNP cord-028721-x6f26ahr 4338 14 's 's POS cord-028721-x6f26ahr 4338 15 syndrome syndrome NN cord-028721-x6f26ahr 4338 16 : : : cord-028721-x6f26ahr 4338 17 a a DT cord-028721-x6f26ahr 4338 18 case case NN cord-028721-x6f26ahr 4338 19 report report NN cord-028721-x6f26ahr 4338 20 . . . cord-028721-x6f26ahr 4339 1 Literature literature NN cord-028721-x6f26ahr 4339 2 review review NN cord-028721-x6f26ahr 4339 3 Trichothiodystrophy Trichothiodystrophy NNP cord-028721-x6f26ahr 4339 4 associated associate VBN cord-028721-x6f26ahr 4339 5 with with IN cord-028721-x6f26ahr 4339 6 photosensitivity photosensitivity NN cord-028721-x6f26ahr 4339 7 , , , cord-028721-x6f26ahr 4339 8 gonadal gonadal JJ cord-028721-x6f26ahr 4339 9 failure failure NN cord-028721-x6f26ahr 4339 10 , , , cord-028721-x6f26ahr 4339 11 and and CC cord-028721-x6f26ahr 4339 12 striking strike VBG cord-028721-x6f26ahr 4339 13 osteosclerosis osteosclerosis NN cord-028721-x6f26ahr 4340 1 Mapping map VBG cord-028721-x6f26ahr 4340 2 a a DT cord-028721-x6f26ahr 4340 3 gene gene NN cord-028721-x6f26ahr 4340 4 for for IN cord-028721-x6f26ahr 4340 5 Noonan Noonan NNP cord-028721-x6f26ahr 4340 6 syndrome syndrome NN cord-028721-x6f26ahr 4340 7 to to IN cord-028721-x6f26ahr 4340 8 the the DT cord-028721-x6f26ahr 4340 9 long long JJ cord-028721-x6f26ahr 4340 10 arm arm NN cord-028721-x6f26ahr 4340 11 of of IN cord-028721-x6f26ahr 4340 12 chromosome chromosome NN cord-028721-x6f26ahr 4340 13 12 12 CD cord-028721-x6f26ahr 4340 14 Noonan Noonan NNP cord-028721-x6f26ahr 4340 15 syndrome syndrome NN cord-028721-x6f26ahr 4340 16 and and CC cord-028721-x6f26ahr 4340 17 related related JJ cord-028721-x6f26ahr 4340 18 disorders disorder NNS cord-028721-x6f26ahr 4340 19 : : : cord-028721-x6f26ahr 4340 20 genetics genetic NNS cord-028721-x6f26ahr 4340 21 and and CC cord-028721-x6f26ahr 4340 22 pathogenesis pathogenesis NN cord-028721-x6f26ahr 4341 1 Testicular testicular JJ cord-028721-x6f26ahr 4341 2 biopsy biopsy NN cord-028721-x6f26ahr 4341 3 and and CC cord-028721-x6f26ahr 4341 4 hormonal hormonal JJ cord-028721-x6f26ahr 4341 5 study study NN cord-028721-x6f26ahr 4341 6 in in IN cord-028721-x6f26ahr 4341 7 a a DT cord-028721-x6f26ahr 4341 8 male male NN cord-028721-x6f26ahr 4341 9 with with IN cord-028721-x6f26ahr 4341 10 Noonan Noonan NNP cord-028721-x6f26ahr 4341 11 's 's POS cord-028721-x6f26ahr 4341 12 Syndrome Syndrome NNP cord-028721-x6f26ahr 4341 13 Purkinje Purkinje NNP cord-028721-x6f26ahr 4341 14 cell cell NN cord-028721-x6f26ahr 4341 15 degeneration degeneration NN cord-028721-x6f26ahr 4341 16 associated associate VBN cord-028721-x6f26ahr 4341 17 with with IN cord-028721-x6f26ahr 4341 18 erythroid erythroid JJ cord-028721-x6f26ahr 4341 19 ankyrin ankyrin NNP cord-028721-x6f26ahr 4341 20 defi defi NNP cord-028721-x6f26ahr 4341 21 ciency ciency NNP cord-028721-x6f26ahr 4341 22 in in IN cord-028721-x6f26ahr 4341 23 nb nb NNP cord-028721-x6f26ahr 4341 24 / / SYM cord-028721-x6f26ahr 4341 25 nb nb NNP cord-028721-x6f26ahr 4341 26 mice mouse NNS cord-028721-x6f26ahr 4341 27 Ataxia Ataxia NNP cord-028721-x6f26ahr 4341 28 and and CC cord-028721-x6f26ahr 4341 29 male male JJ cord-028721-x6f26ahr 4341 30 sterility sterility NN cord-028721-x6f26ahr 4341 31 ( ( -LRB- cord-028721-x6f26ahr 4341 32 AMS AMS NNP cord-028721-x6f26ahr 4341 33 ) ) -RRB- cord-028721-x6f26ahr 4341 34 mouse mouse NN cord-028721-x6f26ahr 4341 35 . . . cord-028721-x6f26ahr 4342 1 A a DT cord-028721-x6f26ahr 4342 2 new new JJ cord-028721-x6f26ahr 4342 3 genetic genetic JJ cord-028721-x6f26ahr 4342 4 variant variant NN cord-028721-x6f26ahr 4342 5 exhibiting exhibit VBG cord-028721-x6f26ahr 4342 6 degeneration degeneration NN cord-028721-x6f26ahr 4342 7 and and CC cord-028721-x6f26ahr 4342 8 loss loss NN cord-028721-x6f26ahr 4342 9 of of IN cord-028721-x6f26ahr 4342 10 cerebellar cerebellar JJ cord-028721-x6f26ahr 4342 11 Purkinje Purkinje NNP cord-028721-x6f26ahr 4342 12 cells cell NNS cord-028721-x6f26ahr 4342 13 and and CC cord-028721-x6f26ahr 4342 14 spermatic spermatic JJ cord-028721-x6f26ahr 4342 15 cells cell NNS cord-028721-x6f26ahr 4343 1 Molecular molecular JJ cord-028721-x6f26ahr 4343 2 structure structure NN cord-028721-x6f26ahr 4343 3 of of IN cord-028721-x6f26ahr 4343 4 the the DT cord-028721-x6f26ahr 4343 5 human human JJ cord-028721-x6f26ahr 4343 6 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4343 7 - - HYPH cord-028721-x6f26ahr 4343 8 releasing release VBG cord-028721-x6f26ahr 4343 9 hormone hormone NN cord-028721-x6f26ahr 4343 10 receptor receptor NN cord-028721-x6f26ahr 4343 11 gene gene NN cord-028721-x6f26ahr 4343 12 Gonadotropin Gonadotropin NNP cord-028721-x6f26ahr 4343 13 - - HYPH cord-028721-x6f26ahr 4343 14 Releasing release VBG cord-028721-x6f26ahr 4343 15 hormone hormone NN cord-028721-x6f26ahr 4343 16 defi defi NNP cord-028721-x6f26ahr 4343 17 ciency ciency NNP cord-028721-x6f26ahr 4343 18 in in IN cord-028721-x6f26ahr 4343 19 the the DT cord-028721-x6f26ahr 4343 20 human human JJ cord-028721-x6f26ahr 4343 21 ( ( -LRB- cord-028721-x6f26ahr 4343 22 idiopathic idiopathic JJ cord-028721-x6f26ahr 4343 23 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4343 24 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 4343 25 and and CC cord-028721-x6f26ahr 4343 26 Kallmann Kallmann NNP cord-028721-x6f26ahr 4343 27 's 's POS cord-028721-x6f26ahr 4343 28 syndrome syndrome NN cord-028721-x6f26ahr 4343 29 ) ) -RRB- cord-028721-x6f26ahr 4343 30 : : : cord-028721-x6f26ahr 4343 31 pathophysiological pathophysiological JJ cord-028721-x6f26ahr 4343 32 and and CC cord-028721-x6f26ahr 4343 33 genetic genetic JJ cord-028721-x6f26ahr 4343 34 considerations consideration NNS cord-028721-x6f26ahr 4343 35 Algunos Algunos NNP cord-028721-x6f26ahr 4343 36 aspectos aspectos NNP cord-028721-x6f26ahr 4343 37 del del NNP cord-028721-x6f26ahr 4343 38 eunucoidismo eunucoidismo NNP cord-028721-x6f26ahr 4343 39 hipogonadotrópico hipogonadotrópico NNP cord-028721-x6f26ahr 4343 40 Complete Complete NNP cord-028721-x6f26ahr 4343 41 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4343 42 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4343 43 associated associate VBN cord-028721-x6f26ahr 4343 44 with with IN cord-028721-x6f26ahr 4343 45 a a DT cord-028721-x6f26ahr 4343 46 novel novel JJ cord-028721-x6f26ahr 4343 47 inactivating inactivate VBG cord-028721-x6f26ahr 4343 48 mutation mutation NN cord-028721-x6f26ahr 4343 49 of of IN cord-028721-x6f26ahr 4343 50 the the DT cord-028721-x6f26ahr 4343 51 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4343 52 - - HYPH cord-028721-x6f26ahr 4343 53 releasing release VBG cord-028721-x6f26ahr 4343 54 hormone hormone NN cord-028721-x6f26ahr 4343 55 receptor receptor NN cord-028721-x6f26ahr 4343 56 Synchronization synchronization NN cord-028721-x6f26ahr 4343 57 of of IN cord-028721-x6f26ahr 4343 58 augmented augment VBN cord-028721-x6f26ahr 4343 59 luteinizing luteinizing JJ cord-028721-x6f26ahr 4343 60 hormone hormone NN cord-028721-x6f26ahr 4343 61 secretion secretion NN cord-028721-x6f26ahr 4343 62 with with IN cord-028721-x6f26ahr 4343 63 sleep sleep NN cord-028721-x6f26ahr 4343 64 during during IN cord-028721-x6f26ahr 4343 65 puberty puberty NNP cord-028721-x6f26ahr 4343 66 Predictors predictor NNS cord-028721-x6f26ahr 4343 67 of of IN cord-028721-x6f26ahr 4343 68 outcome outcome NN cord-028721-x6f26ahr 4343 69 of of IN cord-028721-x6f26ahr 4343 70 longterm longterm JJ cord-028721-x6f26ahr 4343 71 GnRH GnRH NNP cord-028721-x6f26ahr 4343 72 therapy therapy NN cord-028721-x6f26ahr 4343 73 in in IN cord-028721-x6f26ahr 4343 74 men man NNS cord-028721-x6f26ahr 4343 75 with with IN cord-028721-x6f26ahr 4343 76 idiopathic idiopathic JJ cord-028721-x6f26ahr 4343 77 hypogonadotropic hypogonadotropic JJ cord-028721-x6f26ahr 4343 78 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4343 79 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 4343 80 due due JJ cord-028721-x6f26ahr 4343 81 to to IN cord-028721-x6f26ahr 4343 82 secondary secondary JJ cord-028721-x6f26ahr 4343 83 testicular testicular NN cord-028721-x6f26ahr 4343 84 failure failure NN cord-028721-x6f26ahr 4344 1 Falta Falta NNP cord-028721-x6f26ahr 4344 2 total total NN cord-028721-x6f26ahr 4344 3 de de NNP cord-028721-x6f26ahr 4344 4 nervios nervios NNP cord-028721-x6f26ahr 4345 1 olfatorios olfatorios NNP cord-028721-x6f26ahr 4345 2 con con NNP cord-028721-x6f26ahr 4345 3 anosmia anosmia NNP cord-028721-x6f26ahr 4345 4 en en IN cord-028721-x6f26ahr 4345 5 un un NNP cord-028721-x6f26ahr 4345 6 individuo individuo NNP cord-028721-x6f26ahr 4345 7 en en NNP cord-028721-x6f26ahr 4346 1 quien quien NNP cord-028721-x6f26ahr 4346 2 existía existía NNP cord-028721-x6f26ahr 4346 3 una una NNP cord-028721-x6f26ahr 4346 4 atrofi atrofi NNP cord-028721-x6f26ahr 4347 1 a a DT cord-028721-x6f26ahr 4347 2 congénita congénita NNP cord-028721-x6f26ahr 4347 3 de de NNP cord-028721-x6f26ahr 4347 4 los los NNP cord-028721-x6f26ahr 4347 5 testículos testículos NNP cord-028721-x6f26ahr 4348 1 y y NNP cord-028721-x6f26ahr 4348 2 miembro miembro NNP cord-028721-x6f26ahr 4348 3 viril viril NNP cord-028721-x6f26ahr 4349 1 The the DT cord-028721-x6f26ahr 4349 2 genetic genetic JJ cord-028721-x6f26ahr 4349 3 aspects aspect NNS cord-028721-x6f26ahr 4349 4 of of IN cord-028721-x6f26ahr 4349 5 primary primary JJ cord-028721-x6f26ahr 4349 6 eunuchoidism eunuchoidism NN cord-028721-x6f26ahr 4350 1 La La NNP cord-028721-x6f26ahr 4350 2 dysplasie dysplasie NNP cord-028721-x6f26ahr 4350 3 olfacto olfacto NNP cord-028721-x6f26ahr 4350 4 - - HYPH cord-028721-x6f26ahr 4350 5 génitale génitale NNP cord-028721-x6f26ahr 4350 6 Polysialic Polysialic NNP cord-028721-x6f26ahr 4350 7 acid acid NN cord-028721-x6f26ahr 4350 8 facilitates facilitate VBZ cord-028721-x6f26ahr 4350 9 migration migration NN cord-028721-x6f26ahr 4350 10 of of IN cord-028721-x6f26ahr 4350 11 luteinizing luteinize VBG cord-028721-x6f26ahr 4350 12 hormonereleasing hormonerelease VBG cord-028721-x6f26ahr 4350 13 hormone hormone NN cord-028721-x6f26ahr 4350 14 neurons neuron NNS cord-028721-x6f26ahr 4350 15 on on IN cord-028721-x6f26ahr 4350 16 vomeronasal vomeronasal NN cord-028721-x6f26ahr 4350 17 axons axon NNS cord-028721-x6f26ahr 4350 18 Mechanisms Mechanisms NNPS cord-028721-x6f26ahr 4350 19 of of IN cord-028721-x6f26ahr 4350 20 disease disease NN cord-028721-x6f26ahr 4350 21 : : : cord-028721-x6f26ahr 4351 1 Insights insight NNS cord-028721-x6f26ahr 4351 2 into into IN cord-028721-x6f26ahr 4351 3 X x NN cord-028721-x6f26ahr 4351 4 - - HYPH cord-028721-x6f26ahr 4351 5 linked link VBN cord-028721-x6f26ahr 4351 6 and and CC cord-028721-x6f26ahr 4351 7 autosomal autosomal JJ cord-028721-x6f26ahr 4351 8 - - HYPH cord-028721-x6f26ahr 4351 9 dominant dominant JJ cord-028721-x6f26ahr 4351 10 Kallmann Kallmann NNP cord-028721-x6f26ahr 4351 11 syndrome syndrome NN cord-028721-x6f26ahr 4351 12 Mutations Mutations NNPS cord-028721-x6f26ahr 4351 13 in in IN cord-028721-x6f26ahr 4351 14 fi fi NNP cord-028721-x6f26ahr 4351 15 broblast broblast JJ cord-028721-x6f26ahr 4351 16 growth growth NN cord-028721-x6f26ahr 4351 17 factor factor NN cord-028721-x6f26ahr 4351 18 receptor receptor NN cord-028721-x6f26ahr 4351 19 1 1 CD cord-028721-x6f26ahr 4351 20 cause cause NN cord-028721-x6f26ahr 4352 1 Kallmann Kallmann NNP cord-028721-x6f26ahr 4352 2 syndrome syndrome NN cord-028721-x6f26ahr 4352 3 with with IN cord-028721-x6f26ahr 4352 4 a a DT cord-028721-x6f26ahr 4352 5 wide wide JJ cord-028721-x6f26ahr 4352 6 spectrum spectrum NN cord-028721-x6f26ahr 4352 7 of of IN cord-028721-x6f26ahr 4352 8 reproductive reproductive JJ cord-028721-x6f26ahr 4352 9 phenotypes phenotype NNS cord-028721-x6f26ahr 4352 10 Pulsatile Pulsatile NNP cord-028721-x6f26ahr 4352 11 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4352 12 - - HYPH cord-028721-x6f26ahr 4352 13 releasing release VBG cord-028721-x6f26ahr 4352 14 therapy therapy NN cord-028721-x6f26ahr 4352 15 in in IN cord-028721-x6f26ahr 4352 16 male male JJ cord-028721-x6f26ahr 4352 17 patients patient NNS cord-028721-x6f26ahr 4352 18 with with IN cord-028721-x6f26ahr 4352 19 Kallmann Kallmann NNP cord-028721-x6f26ahr 4352 20 's 's POS cord-028721-x6f26ahr 4352 21 syndrome syndrome NN cord-028721-x6f26ahr 4352 22 or or CC cord-028721-x6f26ahr 4352 23 constitutional constitutional JJ cord-028721-x6f26ahr 4352 24 delay delay NN cord-028721-x6f26ahr 4352 25 of of IN cord-028721-x6f26ahr 4352 26 puberty puberty NN cord-028721-x6f26ahr 4353 1 Hipogonadismo Hipogonadismo NNP cord-028721-x6f26ahr 4353 2 hipogonadotrópico hipogonadotrópico NN cord-028721-x6f26ahr 4353 3 con con NN cord-028721-x6f26ahr 4353 4 anosmia anosmia NN cord-028721-x6f26ahr 4353 5 Electron Electron NNP cord-028721-x6f26ahr 4353 6 microscopic microscopic JJ cord-028721-x6f26ahr 4353 7 studies study NNS cord-028721-x6f26ahr 4353 8 of of IN cord-028721-x6f26ahr 4353 9 testes testis NNS cord-028721-x6f26ahr 4353 10 in in IN cord-028721-x6f26ahr 4353 11 Kallmann Kallmann NNP cord-028721-x6f26ahr 4353 12 syndrome syndrome NN cord-028721-x6f26ahr 4353 13 Seminoma Seminoma NNP cord-028721-x6f26ahr 4353 14 in in IN cord-028721-x6f26ahr 4353 15 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4353 16 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4353 17 associated associate VBN cord-028721-x6f26ahr 4353 18 with with IN cord-028721-x6f26ahr 4353 19 anosmia anosmia NN cord-028721-x6f26ahr 4353 20 ( ( -LRB- cord-028721-x6f26ahr 4353 21 Kallmann Kallmann NNP cord-028721-x6f26ahr 4353 22 's 's POS cord-028721-x6f26ahr 4353 23 syndrome syndrome NN cord-028721-x6f26ahr 4353 24 ) ) -RRB- cord-028721-x6f26ahr 4354 1 Clinical clinical JJ cord-028721-x6f26ahr 4354 2 and and CC cord-028721-x6f26ahr 4354 3 hormonal hormonal JJ cord-028721-x6f26ahr 4354 4 features feature NNS cord-028721-x6f26ahr 4354 5 of of IN cord-028721-x6f26ahr 4354 6 selective selective JJ cord-028721-x6f26ahr 4354 7 follicle follicle NN cord-028721-x6f26ahr 4354 8 - - HYPH cord-028721-x6f26ahr 4354 9 stimulating stimulate VBG cord-028721-x6f26ahr 4354 10 hormone hormone NN cord-028721-x6f26ahr 4354 11 ( ( -LRB- cord-028721-x6f26ahr 4354 12 FSH fsh NN cord-028721-x6f26ahr 4354 13 ) ) -RRB- cord-028721-x6f26ahr 4354 14 defi defi NNP cord-028721-x6f26ahr 4354 15 ciency ciency NNP cord-028721-x6f26ahr 4354 16 due due IN cord-028721-x6f26ahr 4354 17 to to IN cord-028721-x6f26ahr 4354 18 FSH FSH NNP cord-028721-x6f26ahr 4354 19 βsubunit βsubunit NNP cord-028721-x6f26ahr 4354 20 gene gene NN cord-028721-x6f26ahr 4354 21 mutations mutation NNS cord-028721-x6f26ahr 4354 22 in in IN cord-028721-x6f26ahr 4354 23 both both DT cord-028721-x6f26ahr 4354 24 sexes sex NNS cord-028721-x6f26ahr 4355 1 Human human JJ cord-028721-x6f26ahr 4355 2 FSH FSH NNP cord-028721-x6f26ahr 4355 3 β β NN cord-028721-x6f26ahr 4355 4 subunit subunit NN cord-028721-x6f26ahr 4355 5 gene gene NN cord-028721-x6f26ahr 4355 6 is be VBZ cord-028721-x6f26ahr 4355 7 highly highly RB cord-028721-x6f26ahr 4355 8 conserved conserve VBN cord-028721-x6f26ahr 4355 9 Isolated isolated JJ cord-028721-x6f26ahr 4355 10 folliclestimulating folliclestimulate VBG cord-028721-x6f26ahr 4355 11 hormone hormone NN cord-028721-x6f26ahr 4355 12 defi defi NNP cord-028721-x6f26ahr 4355 13 ciency ciency NNP cord-028721-x6f26ahr 4355 14 in in IN cord-028721-x6f26ahr 4355 15 men man NNS cord-028721-x6f26ahr 4355 16 : : : cord-028721-x6f26ahr 4355 17 successful successful JJ cord-028721-x6f26ahr 4355 18 long long JJ cord-028721-x6f26ahr 4355 19 - - HYPH cord-028721-x6f26ahr 4355 20 term term NN cord-028721-x6f26ahr 4355 21 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4355 22 therapy therapy NN cord-028721-x6f26ahr 4355 23 Síndrome Síndrome NNP cord-028721-x6f26ahr 4355 24 hipoandrogénico hipoandrogénico NNP cord-028721-x6f26ahr 4355 25 con con FW cord-028721-x6f26ahr 4355 26 gametogénesis gametogénesis NNP cord-028721-x6f26ahr 4355 27 conservada conservada NNP cord-028721-x6f26ahr 4355 28 : : : cord-028721-x6f26ahr 4355 29 clasifi clasifi NNP cord-028721-x6f26ahr 4355 30 cación cación NNP cord-028721-x6f26ahr 4355 31 de de FW cord-028721-x6f26ahr 4355 32 la la FW cord-028721-x6f26ahr 4355 33 insufi insufi NNP cord-028721-x6f26ahr 4356 1 ciencia ciencia NNP cord-028721-x6f26ahr 4356 2 testicular testicular NNP cord-028721-x6f26ahr 4356 3 Hypoandrogenic Hypoandrogenic NNP cord-028721-x6f26ahr 4356 4 syndrome syndrome NN cord-028721-x6f26ahr 4356 5 with with IN cord-028721-x6f26ahr 4356 6 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4356 7 A a DT cord-028721-x6f26ahr 4356 8 syndrome syndrome NN cord-028721-x6f26ahr 4356 9 of of IN cord-028721-x6f26ahr 4356 10 eunuchoidism eunuchoidism NN cord-028721-x6f26ahr 4356 11 with with IN cord-028721-x6f26ahr 4356 12 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4356 13 , , , cord-028721-x6f26ahr 4356 14 normal normal JJ cord-028721-x6f26ahr 4356 15 urinary urinary JJ cord-028721-x6f26ahr 4356 16 FSH fsh NN cord-028721-x6f26ahr 4356 17 , , , cord-028721-x6f26ahr 4356 18 and and CC cord-028721-x6f26ahr 4356 19 low low JJ cord-028721-x6f26ahr 4356 20 - - HYPH cord-028721-x6f26ahr 4356 21 normal normal JJ cord-028721-x6f26ahr 4356 22 ICSH icsh NN cord-028721-x6f26ahr 4356 23 ( ( -LRB- cord-028721-x6f26ahr 4356 24 ' ' `` cord-028721-x6f26ahr 4356 25 fertile fertile JJ cord-028721-x6f26ahr 4356 26 eunuchs eunuch NNS cord-028721-x6f26ahr 4356 27 ' ' '' cord-028721-x6f26ahr 4356 28 ) ) -RRB- cord-028721-x6f26ahr 4357 1 Fertile fertile JJ cord-028721-x6f26ahr 4357 2 eunuch eunuch NN cord-028721-x6f26ahr 4357 3 syndrome syndrome NN cord-028721-x6f26ahr 4357 4 with with IN cord-028721-x6f26ahr 4357 5 the the DT cord-028721-x6f26ahr 4357 6 mutations mutation NNS cord-028721-x6f26ahr 4357 7 ( ( -LRB- cord-028721-x6f26ahr 4357 8 Trp8Arg Trp8Arg NNP cord-028721-x6f26ahr 4357 9 and and CC cord-028721-x6f26ahr 4357 10 Ile15Thr Ile15Thr NNP cord-028721-x6f26ahr 4357 11 ) ) -RRB- cord-028721-x6f26ahr 4357 12 in in IN cord-028721-x6f26ahr 4357 13 the the DT cord-028721-x6f26ahr 4357 14 β β NNP cord-028721-x6f26ahr 4357 15 subunit subunit NN cord-028721-x6f26ahr 4357 16 of of IN cord-028721-x6f26ahr 4357 17 luteinizing luteinize VBG cord-028721-x6f26ahr 4357 18 hormone hormone NN cord-028721-x6f26ahr 4358 1 The the DT cord-028721-x6f26ahr 4358 2 fertile fertile JJ cord-028721-x6f26ahr 4358 3 eunuch eunuch NN cord-028721-x6f26ahr 4358 4 variant variant NN cord-028721-x6f26ahr 4358 5 of of IN cord-028721-x6f26ahr 4358 6 idiopathic idiopathic JJ cord-028721-x6f26ahr 4358 7 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4358 8 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4358 9 : : : cord-028721-x6f26ahr 4358 10 spontaneous spontaneous JJ cord-028721-x6f26ahr 4358 11 reversal reversal NN cord-028721-x6f26ahr 4358 12 associated associate VBN cord-028721-x6f26ahr 4358 13 with with IN cord-028721-x6f26ahr 4358 14 a a DT cord-028721-x6f26ahr 4358 15 homozygous homozygous JJ cord-028721-x6f26ahr 4358 16 mutation mutation NN cord-028721-x6f26ahr 4358 17 in in IN cord-028721-x6f26ahr 4358 18 the the DT cord-028721-x6f26ahr 4358 19 gonadotropinreleasing gonadotropinrelease VBG cord-028721-x6f26ahr 4358 20 hormone hormone NN cord-028721-x6f26ahr 4358 21 receptor receptor NN cord-028721-x6f26ahr 4358 22 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 4358 23 caused cause VBD cord-028721-x6f26ahr 4358 24 by by IN cord-028721-x6f26ahr 4358 25 a a DT cord-028721-x6f26ahr 4358 26 single single JJ cord-028721-x6f26ahr 4358 27 amino amino NN cord-028721-x6f26ahr 4358 28 acid acid NN cord-028721-x6f26ahr 4358 29 substitution substitution NN cord-028721-x6f26ahr 4358 30 in in IN cord-028721-x6f26ahr 4358 31 the the DT cord-028721-x6f26ahr 4358 32 β β NNP cord-028721-x6f26ahr 4358 33 subunit subunit NN cord-028721-x6f26ahr 4358 34 of of IN cord-028721-x6f26ahr 4358 35 luteinzing luteinze VBG cord-028721-x6f26ahr 4358 36 hormone hormone NN cord-028721-x6f26ahr 4358 37 FSH FSH NNP cord-028721-x6f26ahr 4358 38 β β NN cord-028721-x6f26ahr 4358 39 gene gene NN cord-028721-x6f26ahr 4358 40 mutations mutation NNS cord-028721-x6f26ahr 4358 41 in in IN cord-028721-x6f26ahr 4358 42 a a DT cord-028721-x6f26ahr 4358 43 female female NN cord-028721-x6f26ahr 4358 44 with with IN cord-028721-x6f26ahr 4358 45 partial partial JJ cord-028721-x6f26ahr 4358 46 breast breast NN cord-028721-x6f26ahr 4358 47 development development NN cord-028721-x6f26ahr 4358 48 and and CC cord-028721-x6f26ahr 4358 49 a a DT cord-028721-x6f26ahr 4358 50 male male JJ cord-028721-x6f26ahr 4358 51 sibling sibling NN cord-028721-x6f26ahr 4358 52 with with IN cord-028721-x6f26ahr 4358 53 normal normal JJ cord-028721-x6f26ahr 4358 54 puberty puberty NN cord-028721-x6f26ahr 4358 55 and and CC cord-028721-x6f26ahr 4358 56 azoospermia azoospermia NN cord-028721-x6f26ahr 4358 57 Gonadal Gonadal NNP cord-028721-x6f26ahr 4358 58 function function NN cord-028721-x6f26ahr 4358 59 and and CC cord-028721-x6f26ahr 4358 60 response response NN cord-028721-x6f26ahr 4358 61 to to IN cord-028721-x6f26ahr 4358 62 growth growth NN cord-028721-x6f26ahr 4358 63 hormone hormone NN cord-028721-x6f26ahr 4358 64 ( ( -LRB- cord-028721-x6f26ahr 4358 65 GH GH NNP cord-028721-x6f26ahr 4358 66 ) ) -RRB- cord-028721-x6f26ahr 4358 67 in in IN cord-028721-x6f26ahr 4358 68 boys boy NNS cord-028721-x6f26ahr 4358 69 with with IN cord-028721-x6f26ahr 4358 70 isolated isolate VBN cord-028721-x6f26ahr 4358 71 GH GH NNP cord-028721-x6f26ahr 4358 72 defi defi NNP cord-028721-x6f26ahr 4358 73 ciency ciency NN cord-028721-x6f26ahr 4358 74 and and CC cord-028721-x6f26ahr 4358 75 to to IN cord-028721-x6f26ahr 4358 76 GH GH NNP cord-028721-x6f26ahr 4358 77 and and CC cord-028721-x6f26ahr 4358 78 gonadotropins gonadotropin NNS cord-028721-x6f26ahr 4358 79 in in IN cord-028721-x6f26ahr 4358 80 boys boy NNS cord-028721-x6f26ahr 4358 81 with with IN cord-028721-x6f26ahr 4358 82 multiple multiple JJ cord-028721-x6f26ahr 4358 83 pituitary pituitary JJ cord-028721-x6f26ahr 4358 84 hormone hormone NN cord-028721-x6f26ahr 4358 85 defi defi NNP cord-028721-x6f26ahr 4358 86 ciencies ciencies NNP cord-028721-x6f26ahr 4359 1 Ein Ein NNP cord-028721-x6f26ahr 4359 2 syndrom syndrom NN cord-028721-x6f26ahr 4359 3 von von NNP cord-028721-x6f26ahr 4359 4 Adipositas Adipositas NNP cord-028721-x6f26ahr 4359 5 , , , cord-028721-x6f26ahr 4359 6 Kleinwuchs Kleinwuchs NNP cord-028721-x6f26ahr 4359 7 , , , cord-028721-x6f26ahr 4359 8 Kryptorchismus Kryptorchismus NNP cord-028721-x6f26ahr 4359 9 , , , cord-028721-x6f26ahr 4359 10 und und IN cord-028721-x6f26ahr 4359 11 Oligophrenie Oligophrenie NNP cord-028721-x6f26ahr 4359 12 nach nach NN cord-028721-x6f26ahr 4359 13 myotonieartigen myotonieartigen NNP cord-028721-x6f26ahr 4359 14 Zustand Zustand NNP cord-028721-x6f26ahr 4359 15 in in IN cord-028721-x6f26ahr 4359 16 Neugeborenenalter Neugeborenenalter NNP cord-028721-x6f26ahr 4359 17 Hypothalamic Hypothalamic NNP cord-028721-x6f26ahr 4359 18 and and CC cord-028721-x6f26ahr 4359 19 gonadal gonadal JJ cord-028721-x6f26ahr 4359 20 components component NNS cord-028721-x6f26ahr 4359 21 of of IN cord-028721-x6f26ahr 4359 22 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4359 23 in in IN cord-028721-x6f26ahr 4359 24 boys boy NNS cord-028721-x6f26ahr 4359 25 with with IN cord-028721-x6f26ahr 4359 26 Prader Prader NNP cord-028721-x6f26ahr 4359 27 - - HYPH cord-028721-x6f26ahr 4359 28 Labhart Labhart NNP cord-028721-x6f26ahr 4359 29 - - HYPH cord-028721-x6f26ahr 4359 30 Willi Willi NNP cord-028721-x6f26ahr 4359 31 syndrome syndrome NN cord-028721-x6f26ahr 4359 32 Cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4359 33 in in IN cord-028721-x6f26ahr 4359 34 the the DT cord-028721-x6f26ahr 4359 35 Prader Prader NNP cord-028721-x6f26ahr 4359 36 - - HYPH cord-028721-x6f26ahr 4359 37 Willi Willi NNP cord-028721-x6f26ahr 4359 38 syndrome syndrome NN cord-028721-x6f26ahr 4360 1 Síndrome Síndrome NNP cord-028721-x6f26ahr 4360 2 de de NNP cord-028721-x6f26ahr 4360 3 Prader Prader NNP cord-028721-x6f26ahr 4360 4 - - HYPH cord-028721-x6f26ahr 4360 5 Willi Willi NNP cord-028721-x6f26ahr 4361 1 A a DT cord-028721-x6f26ahr 4361 2 fi fi NN cord-028721-x6f26ahr 4361 3 fth fth NN cord-028721-x6f26ahr 4361 4 locus locus NN cord-028721-x6f26ahr 4361 5 for for IN cord-028721-x6f26ahr 4361 6 Bardet Bardet NNP cord-028721-x6f26ahr 4361 7 - - HYPH cord-028721-x6f26ahr 4361 8 Biedl Biedl NNP cord-028721-x6f26ahr 4361 9 syndrome syndrome NN cord-028721-x6f26ahr 4361 10 maps map NNS cord-028721-x6f26ahr 4362 1 to to TO cord-028721-x6f26ahr 4362 2 chromosome chromosome VB cord-028721-x6f26ahr 4362 3 2q31 2q31 CD cord-028721-x6f26ahr 4363 1 Bardet Bardet NNP cord-028721-x6f26ahr 4363 2 - - HYPH cord-028721-x6f26ahr 4363 3 Biedl Biedl NNP cord-028721-x6f26ahr 4363 4 syndrome syndrome NN cord-028721-x6f26ahr 4363 5 : : : cord-028721-x6f26ahr 4363 6 an an DT cord-028721-x6f26ahr 4363 7 emerging emerge VBG cord-028721-x6f26ahr 4363 8 pathomechanism pathomechanism NN cord-028721-x6f26ahr 4363 9 of of IN cord-028721-x6f26ahr 4363 10 intracellular intracellular JJ cord-028721-x6f26ahr 4363 11 transport transport NN cord-028721-x6f26ahr 4364 1 An an DT cord-028721-x6f26ahr 4364 2 atypical atypical JJ cord-028721-x6f26ahr 4364 3 contiguous contiguous JJ cord-028721-x6f26ahr 4364 4 gene gene NN cord-028721-x6f26ahr 4364 5 syndrome syndrome NN cord-028721-x6f26ahr 4364 6 : : : cord-028721-x6f26ahr 4364 7 molecular molecular JJ cord-028721-x6f26ahr 4364 8 studies study NNS cord-028721-x6f26ahr 4364 9 in in IN cord-028721-x6f26ahr 4364 10 a a DT cord-028721-x6f26ahr 4364 11 family family NN cord-028721-x6f26ahr 4364 12 with with IN cord-028721-x6f26ahr 4364 13 Xlinked Xlinked NNP cord-028721-x6f26ahr 4364 14 Kallmann Kallmann NNP cord-028721-x6f26ahr 4364 15 's 's POS cord-028721-x6f26ahr 4364 16 syndrome syndrome NN cord-028721-x6f26ahr 4364 17 and and CC cord-028721-x6f26ahr 4364 18 Xlinked Xlinked NNP cord-028721-x6f26ahr 4364 19 ichthyosis ichthyosis NN cord-028721-x6f26ahr 4364 20 Johnson Johnson NNP cord-028721-x6f26ahr 4364 21 - - HYPH cord-028721-x6f26ahr 4364 22 McMillin McMillin NNP cord-028721-x6f26ahr 4364 23 syndrome syndrome NN cord-028721-x6f26ahr 4364 24 : : : cord-028721-x6f26ahr 4364 25 report report NN cord-028721-x6f26ahr 4364 26 of of IN cord-028721-x6f26ahr 4364 27 a a DT cord-028721-x6f26ahr 4364 28 new new JJ cord-028721-x6f26ahr 4364 29 case case NN cord-028721-x6f26ahr 4364 30 with with IN cord-028721-x6f26ahr 4364 31 novel novel NN cord-028721-x6f26ahr 4364 32 features feature NNS cord-028721-x6f26ahr 4365 1 A a DT cord-028721-x6f26ahr 4365 2 single single JJ cord-028721-x6f26ahr 4365 3 ataxia ataxia NN cord-028721-x6f26ahr 4365 4 telangiectasia telangiectasia NN cord-028721-x6f26ahr 4365 5 gene gene NN cord-028721-x6f26ahr 4365 6 with with IN cord-028721-x6f26ahr 4365 7 a a DT cord-028721-x6f26ahr 4365 8 product product NN cord-028721-x6f26ahr 4365 9 similar similar JJ cord-028721-x6f26ahr 4365 10 to to IN cord-028721-x6f26ahr 4365 11 PI-3 PI-3 NNP cord-028721-x6f26ahr 4365 12 kinase kinase NN cord-028721-x6f26ahr 4365 13 Ataxiatelangiectasia Ataxiatelangiectasia NNP cord-028721-x6f26ahr 4365 14 and and CC cord-028721-x6f26ahr 4365 15 related related JJ cord-028721-x6f26ahr 4365 16 diseases disease NNS cord-028721-x6f26ahr 4366 1 The the DT cord-028721-x6f26ahr 4366 2 Friedreich Friedreich NNP cord-028721-x6f26ahr 4366 3 's 's POS cord-028721-x6f26ahr 4366 4 ataxia ataxia NN cord-028721-x6f26ahr 4366 5 gene gene NN cord-028721-x6f26ahr 4366 6 encodes encode VBZ cord-028721-x6f26ahr 4366 7 a a DT cord-028721-x6f26ahr 4366 8 novel novel NN cord-028721-x6f26ahr 4366 9 phosphatidylinositol-4-phosphatase phosphatidylinositol-4-phosphatase NNP cord-028721-x6f26ahr 4366 10 5-kinase 5-kinase CD cord-028721-x6f26ahr 4366 11 Friedreich Friedreich NNP cord-028721-x6f26ahr 4366 12 ataxia ataxia NN cord-028721-x6f26ahr 4366 13 : : : cord-028721-x6f26ahr 4366 14 Detection detection NN cord-028721-x6f26ahr 4366 15 of of IN cord-028721-x6f26ahr 4366 16 GAA GAA NNP cord-028721-x6f26ahr 4366 17 repeat repeat NN cord-028721-x6f26ahr 4366 18 expansions expansion NNS cord-028721-x6f26ahr 4366 19 and and CC cord-028721-x6f26ahr 4366 20 frataxin frataxin NN cord-028721-x6f26ahr 4366 21 point point NN cord-028721-x6f26ahr 4366 22 mutations mutation NNS cord-028721-x6f26ahr 4367 1 Endocrine endocrine JJ cord-028721-x6f26ahr 4367 2 evaluation evaluation NN cord-028721-x6f26ahr 4367 3 of of IN cord-028721-x6f26ahr 4367 4 infertile infertile JJ cord-028721-x6f26ahr 4367 5 men man NNS cord-028721-x6f26ahr 4367 6 Idiopathic idiopathic JJ cord-028721-x6f26ahr 4367 7 hypogonadotropic hypogonadotropic JJ cord-028721-x6f26ahr 4367 8 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4367 9 in in IN cord-028721-x6f26ahr 4367 10 a a DT cord-028721-x6f26ahr 4367 11 male male JJ cord-028721-x6f26ahr 4367 12 runner runner NN cord-028721-x6f26ahr 4367 13 is be VBZ cord-028721-x6f26ahr 4367 14 reversed reverse VBN cord-028721-x6f26ahr 4367 15 by by IN cord-028721-x6f26ahr 4367 16 clomiphene clomiphene NNP cord-028721-x6f26ahr 4367 17 citrate citrate NNP cord-028721-x6f26ahr 4367 18 Endocrine Endocrine NNP cord-028721-x6f26ahr 4367 19 function function NN cord-028721-x6f26ahr 4367 20 after after IN cord-028721-x6f26ahr 4367 21 spontaneous spontaneous JJ cord-028721-x6f26ahr 4367 22 infarction infarction NN cord-028721-x6f26ahr 4367 23 of of IN cord-028721-x6f26ahr 4367 24 the the DT cord-028721-x6f26ahr 4367 25 human human JJ cord-028721-x6f26ahr 4367 26 pituitary pituitary NN cord-028721-x6f26ahr 4367 27 Acquired acquire VBN cord-028721-x6f26ahr 4367 28 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4367 29 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4367 30 presenting present VBG cord-028721-x6f26ahr 4367 31 as as IN cord-028721-x6f26ahr 4367 32 decreased decrease VBN cord-028721-x6f26ahr 4367 33 seminal seminal JJ cord-028721-x6f26ahr 4367 34 volume volume NN cord-028721-x6f26ahr 4367 35 Gonadotropin Gonadotropin NNP cord-028721-x6f26ahr 4367 36 - - HYPH cord-028721-x6f26ahr 4367 37 secreting secrete VBG cord-028721-x6f26ahr 4367 38 pituitary pituitary JJ cord-028721-x6f26ahr 4367 39 adenoma adenoma NN cord-028721-x6f26ahr 4367 40 with with IN cord-028721-x6f26ahr 4367 41 concomitant concomitant JJ cord-028721-x6f26ahr 4367 42 hypersecretion hypersecretion NN cord-028721-x6f26ahr 4367 43 of of IN cord-028721-x6f26ahr 4367 44 testosterone testosterone NN cord-028721-x6f26ahr 4367 45 and and CC cord-028721-x6f26ahr 4367 46 elevated elevated JJ cord-028721-x6f26ahr 4367 47 sperm sperm NN cord-028721-x6f26ahr 4367 48 count count NN cord-028721-x6f26ahr 4367 49 . . . cord-028721-x6f26ahr 4368 1 Treatment treatment NN cord-028721-x6f26ahr 4368 2 with with IN cord-028721-x6f26ahr 4368 3 LRH LRH NNP cord-028721-x6f26ahr 4368 4 agonists agonist NNS cord-028721-x6f26ahr 4368 5 Testicular Testicular NNP cord-028721-x6f26ahr 4368 6 enlargement enlargement NN cord-028721-x6f26ahr 4368 7 and and CC cord-028721-x6f26ahr 4368 8 elevated elevated JJ cord-028721-x6f26ahr 4368 9 serum serum NN cord-028721-x6f26ahr 4368 10 inhibin inhibin NN cord-028721-x6f26ahr 4368 11 concentrations concentration NNS cord-028721-x6f26ahr 4368 12 occur occur VBP cord-028721-x6f26ahr 4368 13 in in IN cord-028721-x6f26ahr 4368 14 patients patient NNS cord-028721-x6f26ahr 4368 15 with with IN cord-028721-x6f26ahr 4368 16 pituitary pituitary JJ cord-028721-x6f26ahr 4368 17 macroadenomas macroadenomas NNP cord-028721-x6f26ahr 4368 18 secreting secrete VBG cord-028721-x6f26ahr 4368 19 follicle follicle NN cord-028721-x6f26ahr 4368 20 stimulating stimulate VBG cord-028721-x6f26ahr 4368 21 hormone hormone NN cord-028721-x6f26ahr 4369 1 The the DT cord-028721-x6f26ahr 4369 2 impotent impotent JJ cord-028721-x6f26ahr 4369 3 couple couple NN cord-028721-x6f26ahr 4369 4 : : : cord-028721-x6f26ahr 4369 5 low low JJ cord-028721-x6f26ahr 4369 6 desire desire NN cord-028721-x6f26ahr 4370 1 Immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4370 2 detection detection NN cord-028721-x6f26ahr 4370 3 of of IN cord-028721-x6f26ahr 4370 4 prolactin prolactin NN cord-028721-x6f26ahr 4370 5 and and CC cord-028721-x6f26ahr 4370 6 its -PRON- PRP$ cord-028721-x6f26ahr 4370 7 receptors receptor NNS cord-028721-x6f26ahr 4370 8 in in IN cord-028721-x6f26ahr 4370 9 human human JJ cord-028721-x6f26ahr 4370 10 testis testis NN cord-028721-x6f26ahr 4370 11 Ultrastructural Ultrastructural NNP cord-028721-x6f26ahr 4370 12 lesions lesion NNS cord-028721-x6f26ahr 4370 13 in in IN cord-028721-x6f26ahr 4370 14 testes testis NNS cord-028721-x6f26ahr 4370 15 from from IN cord-028721-x6f26ahr 4370 16 hyperprolactinemic hyperprolactinemic NN cord-028721-x6f26ahr 4370 17 men man NNS cord-028721-x6f26ahr 4370 18 Infl Infl NNP cord-028721-x6f26ahr 4370 19 uence uence NN cord-028721-x6f26ahr 4370 20 of of IN cord-028721-x6f26ahr 4370 21 serum serum NN cord-028721-x6f26ahr 4370 22 prolactin prolactin NN cord-028721-x6f26ahr 4370 23 on on IN cord-028721-x6f26ahr 4370 24 semen semen NN cord-028721-x6f26ahr 4370 25 characteristics characteristic NNS cord-028721-x6f26ahr 4370 26 and and CC cord-028721-x6f26ahr 4370 27 sperm sperm NN cord-028721-x6f26ahr 4370 28 function function NN cord-028721-x6f26ahr 4370 29 Return Return NNP cord-028721-x6f26ahr 4370 30 of of IN cord-028721-x6f26ahr 4370 31 gonadal gonadal JJ cord-028721-x6f26ahr 4370 32 function function NN cord-028721-x6f26ahr 4370 33 in in IN cord-028721-x6f26ahr 4370 34 men man NNS cord-028721-x6f26ahr 4370 35 with with IN cord-028721-x6f26ahr 4370 36 prolactin prolactin NN cord-028721-x6f26ahr 4370 37 - - HYPH cord-028721-x6f26ahr 4370 38 secreting secrete VBG cord-028721-x6f26ahr 4370 39 tumors tumor NNS cord-028721-x6f26ahr 4370 40 Serum serum NN cord-028721-x6f26ahr 4370 41 levels level NNS cord-028721-x6f26ahr 4370 42 of of IN cord-028721-x6f26ahr 4370 43 free free JJ cord-028721-x6f26ahr 4370 44 and and CC cord-028721-x6f26ahr 4370 45 bound bind VBN cord-028721-x6f26ahr 4370 46 testosterone testosterone NN cord-028721-x6f26ahr 4370 47 in in IN cord-028721-x6f26ahr 4370 48 hyperthyroidism hyperthyroidism NN cord-028721-x6f26ahr 4370 49 Testicular Testicular NNP cord-028721-x6f26ahr 4370 50 function function NN cord-028721-x6f26ahr 4370 51 in in IN cord-028721-x6f26ahr 4370 52 hyperthyroidism hyperthyroidism NN cord-028721-x6f26ahr 4370 53 Graves'autoimmune Graves'autoimmune NNP cord-028721-x6f26ahr 4370 54 serum serum NN cord-028721-x6f26ahr 4370 55 inhibits inhibit VBZ cord-028721-x6f26ahr 4370 56 gonadal gonadal JJ cord-028721-x6f26ahr 4370 57 steroidogenesis steroidogenesis NN cord-028721-x6f26ahr 4370 58 . . . cord-028721-x6f26ahr 4371 1 Development development NN cord-028721-x6f26ahr 4371 2 of of IN cord-028721-x6f26ahr 4371 3 a a DT cord-028721-x6f26ahr 4371 4 Leydig Leydig NNP cord-028721-x6f26ahr 4371 5 cell cell NN cord-028721-x6f26ahr 4371 6 bioassay bioassay NN cord-028721-x6f26ahr 4371 7 to to TO cord-028721-x6f26ahr 4371 8 identify identify VB cord-028721-x6f26ahr 4371 9 broad broad JJ cord-028721-x6f26ahr 4371 10 spectrum spectrum JJ cord-028721-x6f26ahr 4371 11 anti anti JJ cord-028721-x6f26ahr 4371 12 - - JJ cord-028721-x6f26ahr 4371 13 endocrine endocrine JJ cord-028721-x6f26ahr 4371 14 autoantibodies autoantibody NNS cord-028721-x6f26ahr 4371 15 Male Male NNP cord-028721-x6f26ahr 4371 16 hypogonodism hypogonodism NN cord-028721-x6f26ahr 4371 17 in in IN cord-028721-x6f26ahr 4371 18 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4371 19 : : : cord-028721-x6f26ahr 4372 1 A a DT cord-028721-x6f26ahr 4372 2 study study NN cord-028721-x6f26ahr 4372 3 of of IN cord-028721-x6f26ahr 4372 4 six six CD cord-028721-x6f26ahr 4372 5 cases case NNS cord-028721-x6f26ahr 4372 6 Male male JJ cord-028721-x6f26ahr 4372 7 reproductive reproductive JJ cord-028721-x6f26ahr 4372 8 function function NN cord-028721-x6f26ahr 4372 9 in in IN cord-028721-x6f26ahr 4372 10 relation relation NN cord-028721-x6f26ahr 4372 11 with with IN cord-028721-x6f26ahr 4372 12 thyroid thyroid NN cord-028721-x6f26ahr 4372 13 alterations alteration NNS cord-028721-x6f26ahr 4372 14 Testicular Testicular NNP cord-028721-x6f26ahr 4372 15 dysfunction dysfunction NN cord-028721-x6f26ahr 4372 16 in in IN cord-028721-x6f26ahr 4372 17 men man NNS cord-028721-x6f26ahr 4372 18 with with IN cord-028721-x6f26ahr 4372 19 primary primary JJ cord-028721-x6f26ahr 4372 20 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4372 21 ; ; : cord-028721-x6f26ahr 4372 22 reversal reversal NN cord-028721-x6f26ahr 4372 23 of of IN cord-028721-x6f26ahr 4372 24 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4372 25 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4372 26 with with IN cord-028721-x6f26ahr 4372 27 replacement replacement NN cord-028721-x6f26ahr 4372 28 thyroxine thyroxine NN cord-028721-x6f26ahr 4372 29 Primary primary JJ cord-028721-x6f26ahr 4372 30 hypothyroidism hypothyroidism NN cord-028721-x6f26ahr 4372 31 and and CC cord-028721-x6f26ahr 4372 32 human human JJ cord-028721-x6f26ahr 4372 33 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4372 34 Serum Serum NNP cord-028721-x6f26ahr 4372 35 hormones hormone NNS cord-028721-x6f26ahr 4372 36 and and CC cord-028721-x6f26ahr 4372 37 seminal seminal JJ cord-028721-x6f26ahr 4372 38 parameters parameter NNS cord-028721-x6f26ahr 4372 39 in in IN cord-028721-x6f26ahr 4372 40 males male NNS cord-028721-x6f26ahr 4372 41 with with IN cord-028721-x6f26ahr 4372 42 thyroid thyroid JJ cord-028721-x6f26ahr 4372 43 disturbance disturbance NN cord-028721-x6f26ahr 4372 44 Thyroid thyroid JJ cord-028721-x6f26ahr 4372 45 function function NN cord-028721-x6f26ahr 4372 46 and and CC cord-028721-x6f26ahr 4372 47 puberty puberty NN cord-028721-x6f26ahr 4372 48 Prepubertal Prepubertal NNP cord-028721-x6f26ahr 4372 49 diagnosis diagnosis NN cord-028721-x6f26ahr 4372 50 of of IN cord-028721-x6f26ahr 4372 51 X x NN cord-028721-x6f26ahr 4372 52 - - HYPH cord-028721-x6f26ahr 4372 53 linked link VBN cord-028721-x6f26ahr 4372 54 congenital congenital JJ cord-028721-x6f26ahr 4372 55 adrenal adrenal JJ cord-028721-x6f26ahr 4372 56 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4372 57 presenting present VBG cord-028721-x6f26ahr 4372 58 after after IN cord-028721-x6f26ahr 4372 59 infancy infancy NN cord-028721-x6f26ahr 4372 60 X X NNS cord-028721-x6f26ahr 4372 61 - - HYPH cord-028721-x6f26ahr 4372 62 linked link VBN cord-028721-x6f26ahr 4372 63 adrenal adrenal JJ cord-028721-x6f26ahr 4372 64 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4372 65 congenita congenita NNP cord-028721-x6f26ahr 4372 66 and and CC cord-028721-x6f26ahr 4372 67 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4372 68 hypogonadism hypogonadism NNP cord-028721-x6f26ahr 4372 69 : : : cord-028721-x6f26ahr 4372 70 report report VB cord-028721-x6f26ahr 4372 71 on on IN cord-028721-x6f26ahr 4372 72 new new JJ cord-028721-x6f26ahr 4372 73 mutation mutation NN cord-028721-x6f26ahr 4372 74 of of IN cord-028721-x6f26ahr 4372 75 the the DT cord-028721-x6f26ahr 4372 76 DAX-1 dax-1 JJ cord-028721-x6f26ahr 4372 77 gene gene NN cord-028721-x6f26ahr 4372 78 in in IN cord-028721-x6f26ahr 4372 79 two two CD cord-028721-x6f26ahr 4372 80 siblings sibling NNS cord-028721-x6f26ahr 4372 81 X x NN cord-028721-x6f26ahr 4372 82 - - HYPH cord-028721-x6f26ahr 4372 83 linked link VBN cord-028721-x6f26ahr 4372 84 adrenal adrenal JJ cord-028721-x6f26ahr 4372 85 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4372 86 congenita congenita NN cord-028721-x6f26ahr 4372 87 : : : cord-028721-x6f26ahr 4372 88 a a DT cord-028721-x6f26ahr 4372 89 mutation mutation NN cord-028721-x6f26ahr 4372 90 in in IN cord-028721-x6f26ahr 4372 91 DAX1 DAX1 NNP cord-028721-x6f26ahr 4372 92 expands expand VBZ cord-028721-x6f26ahr 4372 93 the the DT cord-028721-x6f26ahr 4372 94 phenotypic phenotypic JJ cord-028721-x6f26ahr 4372 95 spectrum spectrum NN cord-028721-x6f26ahr 4372 96 in in IN cord-028721-x6f26ahr 4372 97 males male NNS cord-028721-x6f26ahr 4372 98 and and CC cord-028721-x6f26ahr 4372 99 females female NNS cord-028721-x6f26ahr 4372 100 Genotyping Genotyping NNP cord-028721-x6f26ahr 4372 101 of of IN cord-028721-x6f26ahr 4372 102 congenital congenital JJ cord-028721-x6f26ahr 4372 103 adrenal adrenal JJ cord-028721-x6f26ahr 4372 104 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4372 105 due due IN cord-028721-x6f26ahr 4372 106 to to IN cord-028721-x6f26ahr 4372 107 21-hydroxylase 21-hydroxylase CD cord-028721-x6f26ahr 4372 108 defi defi NNP cord-028721-x6f26ahr 4372 109 ciency ciency NNP cord-028721-x6f26ahr 4372 110 presenting present VBG cord-028721-x6f26ahr 4372 111 as as IN cord-028721-x6f26ahr 4372 112 male male JJ cord-028721-x6f26ahr 4372 113 infertility infertility NN cord-028721-x6f26ahr 4372 114 : : : cord-028721-x6f26ahr 4373 1 Case case NN cord-028721-x6f26ahr 4373 2 report report NN cord-028721-x6f26ahr 4373 3 and and CC cord-028721-x6f26ahr 4373 4 literature literature NN cord-028721-x6f26ahr 4373 5 review review NN cord-028721-x6f26ahr 4373 6 Male male JJ cord-028721-x6f26ahr 4373 7 infertility infertility NN cord-028721-x6f26ahr 4373 8 due due IN cord-028721-x6f26ahr 4373 9 to to IN cord-028721-x6f26ahr 4373 10 congenital congenital JJ cord-028721-x6f26ahr 4373 11 adrenal adrenal JJ cord-028721-x6f26ahr 4373 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4373 13 : : : cord-028721-x6f26ahr 4374 1 testicular testicular NNP cord-028721-x6f26ahr 4374 2 biopsy biopsy NNP cord-028721-x6f26ahr 4374 3 fi fi NNP cord-028721-x6f26ahr 4374 4 ndings nding NNS cord-028721-x6f26ahr 4374 5 , , , cord-028721-x6f26ahr 4374 6 hormonal hormonal JJ cord-028721-x6f26ahr 4374 7 evaluation evaluation NN cord-028721-x6f26ahr 4374 8 , , , cord-028721-x6f26ahr 4374 9 and and CC cord-028721-x6f26ahr 4374 10 therapeutic therapeutic JJ cord-028721-x6f26ahr 4374 11 results result NNS cord-028721-x6f26ahr 4374 12 in in IN cord-028721-x6f26ahr 4374 13 three three CD cord-028721-x6f26ahr 4374 14 patients patient NNS cord-028721-x6f26ahr 4374 15 Adrenal adrenal JJ cord-028721-x6f26ahr 4374 16 rest rest NN cord-028721-x6f26ahr 4374 17 tumors tumor NNS cord-028721-x6f26ahr 4374 18 of of IN cord-028721-x6f26ahr 4374 19 the the DT cord-028721-x6f26ahr 4374 20 testes testis NNS cord-028721-x6f26ahr 4374 21 Bilateral bilateral JJ cord-028721-x6f26ahr 4374 22 testicular testicular JJ cord-028721-x6f26ahr 4374 23 adrenal adrenal JJ cord-028721-x6f26ahr 4374 24 rests rest VBZ cord-028721-x6f26ahr 4374 25 in in IN cord-028721-x6f26ahr 4374 26 a a DT cord-028721-x6f26ahr 4374 27 patient patient NN cord-028721-x6f26ahr 4374 28 with with IN cord-028721-x6f26ahr 4374 29 11-hydroxylase 11-hydroxylase CD cord-028721-x6f26ahr 4374 30 defi defi NNP cord-028721-x6f26ahr 4374 31 cient cient NNP cord-028721-x6f26ahr 4374 32 congenital congenital JJ cord-028721-x6f26ahr 4374 33 adrenal adrenal JJ cord-028721-x6f26ahr 4374 34 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4374 35 Infertility Infertility NNP cord-028721-x6f26ahr 4374 36 caused cause VBN cord-028721-x6f26ahr 4374 37 by by IN cord-028721-x6f26ahr 4374 38 bilateral bilateral JJ cord-028721-x6f26ahr 4374 39 testicular testicular JJ cord-028721-x6f26ahr 4374 40 masses masse NNS cord-028721-x6f26ahr 4374 41 secondary secondary JJ cord-028721-x6f26ahr 4374 42 to to IN cord-028721-x6f26ahr 4374 43 congenital congenital JJ cord-028721-x6f26ahr 4374 44 adrenal adrenal JJ cord-028721-x6f26ahr 4374 45 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4374 46 ( ( -LRB- cord-028721-x6f26ahr 4374 47 21-hydroxylase 21-hydroxylase CD cord-028721-x6f26ahr 4374 48 defi defi NNP cord-028721-x6f26ahr 4374 49 ciency ciency NNP cord-028721-x6f26ahr 4374 50 ) ) -RRB- cord-028721-x6f26ahr 4375 1 Elevated elevated JJ cord-028721-x6f26ahr 4375 2 17-hydroxyprogesterone 17-hydroxyprogesterone CD cord-028721-x6f26ahr 4375 3 and and CC cord-028721-x6f26ahr 4375 4 testosterone testosterone NN cord-028721-x6f26ahr 4375 5 in in IN cord-028721-x6f26ahr 4375 6 a a DT cord-028721-x6f26ahr 4375 7 newborn newborn NN cord-028721-x6f26ahr 4375 8 with with IN cord-028721-x6f26ahr 4375 9 3β 3β CD cord-028721-x6f26ahr 4375 10 - - HYPH cord-028721-x6f26ahr 4375 11 hydroxysteroid hydroxysteroid NN cord-028721-x6f26ahr 4375 12 dehydrogenase dehydrogenase NN cord-028721-x6f26ahr 4375 13 defi defi NN cord-028721-x6f26ahr 4375 14 ciency ciency NN cord-028721-x6f26ahr 4375 15 . . . cord-028721-x6f26ahr 4376 1 N N NNP cord-028721-x6f26ahr 4377 1 Eng Eng NNP cord-028721-x6f26ahr 4377 2 l l NNP cord-028721-x6f26ahr 4377 3 Congenital Congenital NNP cord-028721-x6f26ahr 4378 1 17 17 CD cord-028721-x6f26ahr 4378 2 alfa alfa NNP cord-028721-x6f26ahr 4378 3 - - HYPH cord-028721-x6f26ahr 4378 4 hydroxylase hydroxylase NNP cord-028721-x6f26ahr 4378 5 defi defi NNP cord-028721-x6f26ahr 4378 6 ciency ciency NNP cord-028721-x6f26ahr 4378 7 : : : cord-028721-x6f26ahr 4379 1 A a DT cord-028721-x6f26ahr 4379 2 clinico clinico NN cord-028721-x6f26ahr 4379 3 - - HYPH cord-028721-x6f26ahr 4379 4 pathologic pathologic JJ cord-028721-x6f26ahr 4379 5 study study NN cord-028721-x6f26ahr 4379 6 Bilateral bilateral JJ cord-028721-x6f26ahr 4379 7 tumors tumor NNS cord-028721-x6f26ahr 4379 8 of of IN cord-028721-x6f26ahr 4379 9 the the DT cord-028721-x6f26ahr 4379 10 testis testis NN cord-028721-x6f26ahr 4379 11 in in IN cord-028721-x6f26ahr 4379 12 21-alpha 21-alpha CD cord-028721-x6f26ahr 4379 13 hydroxylase hydroxylase NN cord-028721-x6f26ahr 4379 14 defi defi NN cord-028721-x6f26ahr 4379 15 ciency ciency NNP cord-028721-x6f26ahr 4379 16 without without IN cord-028721-x6f26ahr 4379 17 adrenal adrenal JJ cord-028721-x6f26ahr 4379 18 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4379 19 Estrogen Estrogen NNP cord-028721-x6f26ahr 4379 20 secreting secrete VBG cord-028721-x6f26ahr 4379 21 adrenal adrenal JJ cord-028721-x6f26ahr 4379 22 adenocarcinoma adenocarcinoma NN cord-028721-x6f26ahr 4379 23 in in IN cord-028721-x6f26ahr 4379 24 an an DT cord-028721-x6f26ahr 4379 25 18-month 18-month JJ cord-028721-x6f26ahr 4379 26 - - HYPH cord-028721-x6f26ahr 4379 27 old old JJ cord-028721-x6f26ahr 4379 28 boy boy NN cord-028721-x6f26ahr 4379 29 : : : cord-028721-x6f26ahr 4379 30 aromatase aromatase NN cord-028721-x6f26ahr 4379 31 activity activity NN cord-028721-x6f26ahr 4379 32 , , , cord-028721-x6f26ahr 4379 33 protein protein NN cord-028721-x6f26ahr 4379 34 expression expression NN cord-028721-x6f26ahr 4379 35 , , , cord-028721-x6f26ahr 4379 36 mRNA mrna NN cord-028721-x6f26ahr 4379 37 and and CC cord-028721-x6f26ahr 4379 38 utilization utilization NN cord-028721-x6f26ahr 4379 39 of of IN cord-028721-x6f26ahr 4379 40 gonadal gonadal JJ cord-028721-x6f26ahr 4379 41 type type NN cord-028721-x6f26ahr 4379 42 promoter promoter NN cord-028721-x6f26ahr 4379 43 Diabetes diabetes NN cord-028721-x6f26ahr 4379 44 mellitus mellitus NN cord-028721-x6f26ahr 4379 45 / / SYM cord-028721-x6f26ahr 4379 46 male male JJ cord-028721-x6f26ahr 4379 47 infertility infertility NN cord-028721-x6f26ahr 4379 48 Growth growth NN cord-028721-x6f26ahr 4379 49 , , , cord-028721-x6f26ahr 4379 50 puberty puberty NN cord-028721-x6f26ahr 4379 51 , , , cord-028721-x6f26ahr 4379 52 and and CC cord-028721-x6f26ahr 4379 53 fi fi FW cord-028721-x6f26ahr 4379 54 nal nal NNP cord-028721-x6f26ahr 4379 55 height height NN cord-028721-x6f26ahr 4379 56 in in IN cord-028721-x6f26ahr 4379 57 children child NNS cord-028721-x6f26ahr 4379 58 with with IN cord-028721-x6f26ahr 4379 59 type type NN cord-028721-x6f26ahr 4379 60 1 1 CD cord-028721-x6f26ahr 4379 61 diabetes diabetes NN cord-028721-x6f26ahr 4379 62 Insulin insulin NN cord-028721-x6f26ahr 4379 63 - - HYPH cord-028721-x6f26ahr 4379 64 dependent dependent JJ cord-028721-x6f26ahr 4379 65 diabetes diabetes NN cord-028721-x6f26ahr 4379 66 affects affect VBZ cord-028721-x6f26ahr 4379 67 testicular testicular JJ cord-028721-x6f26ahr 4379 68 function function NN cord-028721-x6f26ahr 4379 69 by by IN cord-028721-x6f26ahr 4379 70 FSHand FSHand NNP cord-028721-x6f26ahr 4379 71 LH LH NNP cord-028721-x6f26ahr 4379 72 - - HYPH cord-028721-x6f26ahr 4379 73 linked link VBN cord-028721-x6f26ahr 4379 74 mechanisms mechanism NNS cord-028721-x6f26ahr 4379 75 Semen semen NN cord-028721-x6f26ahr 4379 76 characteristics characteristic NNS cord-028721-x6f26ahr 4379 77 and and CC cord-028721-x6f26ahr 4379 78 diabetes diabetes NN cord-028721-x6f26ahr 4379 79 mellitus mellitus NN cord-028721-x6f26ahr 4379 80 : : : cord-028721-x6f26ahr 4379 81 signifi signifi NNP cord-028721-x6f26ahr 4379 82 cance cance NN cord-028721-x6f26ahr 4379 83 of of IN cord-028721-x6f26ahr 4379 84 insulin insulin NN cord-028721-x6f26ahr 4379 85 in in IN cord-028721-x6f26ahr 4379 86 male male JJ cord-028721-x6f26ahr 4379 87 infertility infertility NN cord-028721-x6f26ahr 4379 88 Interstitial interstitial JJ cord-028721-x6f26ahr 4379 89 compartment compartment NN cord-028721-x6f26ahr 4379 90 pathology pathology NN cord-028721-x6f26ahr 4379 91 and and CC cord-028721-x6f26ahr 4379 92 spermatogenic spermatogenic JJ cord-028721-x6f26ahr 4379 93 disruption disruption NN cord-028721-x6f26ahr 4379 94 in in IN cord-028721-x6f26ahr 4379 95 testes testis NNS cord-028721-x6f26ahr 4379 96 from from IN cord-028721-x6f26ahr 4379 97 impotent impotent JJ cord-028721-x6f26ahr 4379 98 diabetic diabetic JJ cord-028721-x6f26ahr 4379 99 men man NNS cord-028721-x6f26ahr 4379 100 Autonomic autonomic JJ cord-028721-x6f26ahr 4379 101 neuropathy neuropathy NN cord-028721-x6f26ahr 4379 102 and and CC cord-028721-x6f26ahr 4379 103 sexual sexual JJ cord-028721-x6f26ahr 4379 104 impotence impotence NN cord-028721-x6f26ahr 4379 105 in in IN cord-028721-x6f26ahr 4379 106 diabetic diabetic JJ cord-028721-x6f26ahr 4379 107 patients patient NNS cord-028721-x6f26ahr 4379 108 : : : cord-028721-x6f26ahr 4379 109 Analisis Analisis NNP cord-028721-x6f26ahr 4379 110 of of IN cord-028721-x6f26ahr 4379 111 cardiovascular cardiovascular JJ cord-028721-x6f26ahr 4379 112 refl refl NNP cord-028721-x6f26ahr 4379 113 exes exes NNP cord-028721-x6f26ahr 4379 114 Mutation Mutation NNP cord-028721-x6f26ahr 4379 115 analysis analysis NN cord-028721-x6f26ahr 4379 116 for for IN cord-028721-x6f26ahr 4379 117 heterozygote heterozygote NN cord-028721-x6f26ahr 4379 118 detection detection NN cord-028721-x6f26ahr 4379 119 and and CC cord-028721-x6f26ahr 4379 120 the the DT cord-028721-x6f26ahr 4379 121 prenatal prenatal JJ cord-028721-x6f26ahr 4379 122 diagnosis diagnosis NN cord-028721-x6f26ahr 4379 123 of of IN cord-028721-x6f26ahr 4379 124 cystic cystic NN cord-028721-x6f26ahr 4379 125 fi fi NN cord-028721-x6f26ahr 4379 126 brosis brosis NN cord-028721-x6f26ahr 4379 127 CFTR CFTR NNP cord-028721-x6f26ahr 4379 128 gene gene NN cord-028721-x6f26ahr 4379 129 mutations mutation NNS cord-028721-x6f26ahr 4379 130 and and CC cord-028721-x6f26ahr 4379 131 male male JJ cord-028721-x6f26ahr 4379 132 infertility infertility NN cord-028721-x6f26ahr 4379 133 Infertility Infertility NNP cord-028721-x6f26ahr 4379 134 in in IN cord-028721-x6f26ahr 4379 135 male male JJ cord-028721-x6f26ahr 4379 136 patients patient NNS cord-028721-x6f26ahr 4379 137 with with IN cord-028721-x6f26ahr 4379 138 cystic cystic NN cord-028721-x6f26ahr 4379 139 fi fi NN cord-028721-x6f26ahr 4379 140 brosis brosis NN cord-028721-x6f26ahr 4379 141 Anomalies Anomalies NNPS cord-028721-x6f26ahr 4379 142 du du NNP cord-028721-x6f26ahr 4379 143 sperme sperme NNP cord-028721-x6f26ahr 4379 144 , , , cord-028721-x6f26ahr 4379 145 des des FW cord-028721-x6f26ahr 4379 146 defferents defferents NNP cord-028721-x6f26ahr 4380 1 et et NNP cord-028721-x6f26ahr 4380 2 de de FW cord-028721-x6f26ahr 4380 3 l'epididyme l'epididyme FW cord-028721-x6f26ahr 4380 4 dans dans FW cord-028721-x6f26ahr 4380 5 la la NNP cord-028721-x6f26ahr 4380 6 mucoviscidose mucoviscidose NNP cord-028721-x6f26ahr 4381 1 A a DT cord-028721-x6f26ahr 4381 2 mutation mutation NN cord-028721-x6f26ahr 4381 3 in in IN cord-028721-x6f26ahr 4381 4 the the DT cord-028721-x6f26ahr 4381 5 second second JJ cord-028721-x6f26ahr 4381 6 nucleotide nucleotide JJ cord-028721-x6f26ahr 4381 7 binding binding NN cord-028721-x6f26ahr 4381 8 fold fold NN cord-028721-x6f26ahr 4381 9 of of IN cord-028721-x6f26ahr 4381 10 the the DT cord-028721-x6f26ahr 4381 11 cystic cystic NN cord-028721-x6f26ahr 4381 12 fi fi NNP cord-028721-x6f26ahr 4381 13 brosis brosis NNP cord-028721-x6f26ahr 4381 14 gene gene NN cord-028721-x6f26ahr 4381 15 Cystic Cystic NNP cord-028721-x6f26ahr 4381 16 fi fi NNP cord-028721-x6f26ahr 4381 17 brosis brosis NN cord-028721-x6f26ahr 4381 18 in in IN cord-028721-x6f26ahr 4381 19 infertility infertility NN cord-028721-x6f26ahr 4381 20 : : : cord-028721-x6f26ahr 4381 21 screening screening NN cord-028721-x6f26ahr 4381 22 before before IN cord-028721-x6f26ahr 4381 23 assisted assist VBN cord-028721-x6f26ahr 4381 24 reproduction reproduction NN cord-028721-x6f26ahr 4381 25 : : : cord-028721-x6f26ahr 4381 26 opinion opinion NN cord-028721-x6f26ahr 4381 27 Autosomal autosomal JJ cord-028721-x6f26ahr 4381 28 recessive recessive JJ cord-028721-x6f26ahr 4381 29 hereditary hereditary JJ cord-028721-x6f26ahr 4381 30 congenital congenital JJ cord-028721-x6f26ahr 4381 31 aplasia aplasia NNS cord-028721-x6f26ahr 4381 32 of of IN cord-028721-x6f26ahr 4381 33 the the DT cord-028721-x6f26ahr 4381 34 vasa vasa NNP cord-028721-x6f26ahr 4381 35 deferentia deferentia NNP cord-028721-x6f26ahr 4381 36 in in IN cord-028721-x6f26ahr 4381 37 four four CD cord-028721-x6f26ahr 4381 38 siblings sibling NNS cord-028721-x6f26ahr 4381 39 Congenital congenital JJ cord-028721-x6f26ahr 4381 40 bilateral bilateral JJ cord-028721-x6f26ahr 4381 41 absence absence NN cord-028721-x6f26ahr 4381 42 of of IN cord-028721-x6f26ahr 4381 43 the the DT cord-028721-x6f26ahr 4381 44 vas vas NNP cord-028721-x6f26ahr 4381 45 deferens deferen NNS cord-028721-x6f26ahr 4381 46 . . . cord-028721-x6f26ahr 4382 1 A a DT cord-028721-x6f26ahr 4382 2 primary primary JJ cord-028721-x6f26ahr 4382 3 genital genital JJ cord-028721-x6f26ahr 4382 4 form form NN cord-028721-x6f26ahr 4382 5 of of IN cord-028721-x6f26ahr 4382 6 cystic cystic NN cord-028721-x6f26ahr 4382 7 fi fi NN cord-028721-x6f26ahr 4382 8 brosis brosis NN cord-028721-x6f26ahr 4382 9 Congenital congenital JJ cord-028721-x6f26ahr 4382 10 mesonephric mesonephric JJ cord-028721-x6f26ahr 4382 11 defects defect NNS cord-028721-x6f26ahr 4382 12 in in IN cord-028721-x6f26ahr 4382 13 male male JJ cord-028721-x6f26ahr 4382 14 infants infant NNS cord-028721-x6f26ahr 4382 15 with with IN cord-028721-x6f26ahr 4382 16 mucoviscidosis mucoviscidosis NN cord-028721-x6f26ahr 4382 17 Genital genital JJ cord-028721-x6f26ahr 4382 18 abnormalities abnormality NNS cord-028721-x6f26ahr 4382 19 in in IN cord-028721-x6f26ahr 4382 20 male male JJ cord-028721-x6f26ahr 4382 21 patients patient NNS cord-028721-x6f26ahr 4382 22 with with IN cord-028721-x6f26ahr 4382 23 cystic cystic NN cord-028721-x6f26ahr 4382 24 fi fi NNP cord-028721-x6f26ahr 4382 25 brosis brosis NN cord-028721-x6f26ahr 4382 26 La La NNP cord-028721-x6f26ahr 4382 27 reviviscenza reviviscenza NNP cord-028721-x6f26ahr 4383 1 mammaria mammaria NNP cord-028721-x6f26ahr 4384 1 nell'uomo nell'uomo NNP cord-028721-x6f26ahr 4384 2 affecto affecto NNP cord-028721-x6f26ahr 4385 1 da da NNP cord-028721-x6f26ahr 4385 2 cirrosi cirrosi NNP cord-028721-x6f26ahr 4385 3 del del DT cord-028721-x6f26ahr 4385 4 Laennec Laennec NNP cord-028721-x6f26ahr 4385 5 Sulla Sulla NNP cord-028721-x6f26ahr 4385 6 c.d c.d NNP cord-028721-x6f26ahr 4385 7 . . . cord-028721-x6f26ahr 4386 1 reviviscenza reviviscenza NNP cord-028721-x6f26ahr 4386 2 della della NNP cord-028721-x6f26ahr 4386 3 mammella mammella FW cord-028721-x6f26ahr 4386 4 maschile maschile NNP cord-028721-x6f26ahr 4386 5 nella nella NNP cord-028721-x6f26ahr 4386 6 cirrosi cirrosi NNP cord-028721-x6f26ahr 4386 7 epatica epatica NNP cord-028721-x6f26ahr 4387 1 ( ( -LRB- cord-028721-x6f26ahr 4387 2 nota nota NNP cord-028721-x6f26ahr 4387 3 preventiva preventiva NNP cord-028721-x6f26ahr 4387 4 ) ) -RRB- cord-028721-x6f26ahr 4388 1 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 4388 2 in in IN cord-028721-x6f26ahr 4388 3 alcoholic alcoholic JJ cord-028721-x6f26ahr 4388 4 liver liver NN cord-028721-x6f26ahr 4388 5 direase direase NN cord-028721-x6f26ahr 4388 6 : : : cord-028721-x6f26ahr 4388 7 evidence evidence NN cord-028721-x6f26ahr 4388 8 for for IN cord-028721-x6f26ahr 4388 9 a a DT cord-028721-x6f26ahr 4388 10 double double JJ cord-028721-x6f26ahr 4388 11 defect defect NN cord-028721-x6f26ahr 4388 12 Effect effect NN cord-028721-x6f26ahr 4388 13 of of IN cord-028721-x6f26ahr 4388 14 chronic chronic JJ cord-028721-x6f26ahr 4388 15 alcoholism alcoholism NN cord-028721-x6f26ahr 4388 16 on on IN cord-028721-x6f26ahr 4388 17 semenstudies semenstudie NNS cord-028721-x6f26ahr 4388 18 on on IN cord-028721-x6f26ahr 4388 19 lipid lipid NN cord-028721-x6f26ahr 4388 20 profi profi NNP cord-028721-x6f26ahr 4388 21 les les NNP cord-028721-x6f26ahr 4388 22 Alterations Alterations NNPS cord-028721-x6f26ahr 4388 23 of of IN cord-028721-x6f26ahr 4388 24 testicular testicular JJ cord-028721-x6f26ahr 4388 25 morphology morphology NN cord-028721-x6f26ahr 4388 26 in in IN cord-028721-x6f26ahr 4388 27 alcoholic alcoholic JJ cord-028721-x6f26ahr 4388 28 disease disease NN cord-028721-x6f26ahr 4388 29 Differential differential NN cord-028721-x6f26ahr 4388 30 binding binding NN cord-028721-x6f26ahr 4388 31 of of IN cord-028721-x6f26ahr 4388 32 testosterone testosterone NN cord-028721-x6f26ahr 4388 33 and and CC cord-028721-x6f26ahr 4388 34 oestradiol oestradiol NN cord-028721-x6f26ahr 4388 35 to to IN cord-028721-x6f26ahr 4388 36 isoforms isoform NNS cord-028721-x6f26ahr 4388 37 of of IN cord-028721-x6f26ahr 4388 38 sex sex NN cord-028721-x6f26ahr 4388 39 hormone hormone NN cord-028721-x6f26ahr 4388 40 binding bind VBG cord-028721-x6f26ahr 4388 41 glolulim glolulim NNP cord-028721-x6f26ahr 4388 42 : : : cord-028721-x6f26ahr 4388 43 selective selective JJ cord-028721-x6f26ahr 4388 44 alteration alteration NN cord-028721-x6f26ahr 4388 45 of of IN cord-028721-x6f26ahr 4388 46 estradiol estradiol NN cord-028721-x6f26ahr 4388 47 binding bind VBG cord-028721-x6f26ahr 4388 48 in in IN cord-028721-x6f26ahr 4388 49 cirrhosis cirrhosis NN cord-028721-x6f26ahr 4388 50 Group Group NNP cord-028721-x6f26ahr 4388 51 for for IN cord-028721-x6f26ahr 4388 52 Liver Liver NNP cord-028721-x6f26ahr 4388 53 Diseases Diseases NNPS cord-028721-x6f26ahr 4388 54 . . . cord-028721-x6f26ahr 4389 1 Serum serum NN cord-028721-x6f26ahr 4389 2 testosterone testosterone NN cord-028721-x6f26ahr 4389 3 concentration concentration NN cord-028721-x6f26ahr 4389 4 in in IN cord-028721-x6f26ahr 4389 5 men man NNS cord-028721-x6f26ahr 4389 6 with with IN cord-028721-x6f26ahr 4389 7 alcoholic alcoholic JJ cord-028721-x6f26ahr 4389 8 cirrhosis cirrhosis NN cord-028721-x6f26ahr 4389 9 : : : cord-028721-x6f26ahr 4389 10 background background NN cord-028721-x6f26ahr 4389 11 for for IN cord-028721-x6f26ahr 4389 12 variation variation NN cord-028721-x6f26ahr 4389 13 Sexual sexual JJ cord-028721-x6f26ahr 4389 14 function function NN cord-028721-x6f26ahr 4389 15 and and CC cord-028721-x6f26ahr 4389 16 testosterone testosterone NN cord-028721-x6f26ahr 4389 17 levels level NNS cord-028721-x6f26ahr 4389 18 in in IN cord-028721-x6f26ahr 4389 19 men man NNS cord-028721-x6f26ahr 4389 20 with with IN cord-028721-x6f26ahr 4389 21 nonalcoholic nonalcoholic JJ cord-028721-x6f26ahr 4389 22 liver liver NN cord-028721-x6f26ahr 4389 23 disease disease NN cord-028721-x6f26ahr 4389 24 Testicular Testicular NNP cord-028721-x6f26ahr 4389 25 function function NN cord-028721-x6f26ahr 4389 26 and and CC cord-028721-x6f26ahr 4389 27 fertility fertility NN cord-028721-x6f26ahr 4389 28 in in IN cord-028721-x6f26ahr 4389 29 men man NNS cord-028721-x6f26ahr 4389 30 with with IN cord-028721-x6f26ahr 4389 31 homozygous homozygous JJ cord-028721-x6f26ahr 4389 32 alpha-1 alpha-1 JJ cord-028721-x6f26ahr 4389 33 antitrypsin antitrypsin NN cord-028721-x6f26ahr 4389 34 defi defi NN cord-028721-x6f26ahr 4389 35 ciency ciency NNP cord-028721-x6f26ahr 4389 36 Hereditary Hereditary NNP cord-028721-x6f26ahr 4389 37 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4390 1 Haemochromatosis Haemochromatosis NNP cord-028721-x6f26ahr 4390 2 and and CC cord-028721-x6f26ahr 4390 3 HLA HLA NNP cord-028721-x6f26ahr 4390 4 - - HYPH cord-028721-x6f26ahr 4390 5 H H NNP cord-028721-x6f26ahr 4391 1 A a DT cord-028721-x6f26ahr 4391 2 novel novel JJ cord-028721-x6f26ahr 4391 3 MHC MHC NNP cord-028721-x6f26ahr 4391 4 class class NN cord-028721-x6f26ahr 4391 5 1-like 1-like CD cord-028721-x6f26ahr 4391 6 gene gene NN cord-028721-x6f26ahr 4391 7 is be VBZ cord-028721-x6f26ahr 4391 8 mutated mutate VBN cord-028721-x6f26ahr 4391 9 in in IN cord-028721-x6f26ahr 4391 10 patients patient NNS cord-028721-x6f26ahr 4391 11 with with IN cord-028721-x6f26ahr 4391 12 hereditary hereditary JJ cord-028721-x6f26ahr 4391 13 haemochromatosis haemochromatosi NNS cord-028721-x6f26ahr 4391 14 Clinical clinical JJ cord-028721-x6f26ahr 4391 15 and and CC cord-028721-x6f26ahr 4391 16 molecular molecular JJ cord-028721-x6f26ahr 4391 17 aspects aspect NNS cord-028721-x6f26ahr 4391 18 of of IN cord-028721-x6f26ahr 4391 19 juvenile juvenile JJ cord-028721-x6f26ahr 4391 20 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4391 21 in in IN cord-028721-x6f26ahr 4391 22 Saguenay Saguenay NNP cord-028721-x6f26ahr 4391 23 Juvenile Juvenile NNP cord-028721-x6f26ahr 4391 24 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4391 25 locus locus NN cord-028721-x6f26ahr 4391 26 maps map NNS cord-028721-x6f26ahr 4391 27 to to IN cord-028721-x6f26ahr 4391 28 chromosome chromosome NN cord-028721-x6f26ahr 4391 29 1q 1q CD cord-028721-x6f26ahr 4391 30 Juvenile juvenile JJ cord-028721-x6f26ahr 4391 31 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4392 1 A a DT cord-028721-x6f26ahr 4392 2 24-year 24-year JJ cord-028721-x6f26ahr 4392 3 - - HYPH cord-028721-x6f26ahr 4392 4 old old JJ cord-028721-x6f26ahr 4392 5 patient patient NN cord-028721-x6f26ahr 4392 6 with with IN cord-028721-x6f26ahr 4392 7 decreased decreased JJ cord-028721-x6f26ahr 4392 8 libido libido NN cord-028721-x6f26ahr 4392 9 and and CC cord-028721-x6f26ahr 4392 10 erectile erectile NN cord-028721-x6f26ahr 4392 11 dysfunction dysfunction NN cord-028721-x6f26ahr 4392 12 as as IN cord-028721-x6f26ahr 4392 13 initial initial JJ cord-028721-x6f26ahr 4392 14 manifestations manifestation NNS cord-028721-x6f26ahr 4392 15 of of IN cord-028721-x6f26ahr 4392 16 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4392 17 Endocrine endocrine JJ cord-028721-x6f26ahr 4392 18 complications complication NNS cord-028721-x6f26ahr 4392 19 of of IN cord-028721-x6f26ahr 4392 20 genetic genetic JJ cord-028721-x6f26ahr 4392 21 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4392 22 Hypogonadism hypogonadism NN cord-028721-x6f26ahr 4392 23 in in IN cord-028721-x6f26ahr 4392 24 hereditary hereditary JJ cord-028721-x6f26ahr 4392 25 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4393 1 The the DT cord-028721-x6f26ahr 4393 2 anterior anterior JJ cord-028721-x6f26ahr 4393 3 pituitary pituitary NN cord-028721-x6f26ahr 4393 4 in in IN cord-028721-x6f26ahr 4393 5 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4393 6 Reversibility Reversibility NNP cord-028721-x6f26ahr 4393 7 of of IN cord-028721-x6f26ahr 4393 8 hypogonadotropic hypogonadotropic NNP cord-028721-x6f26ahr 4393 9 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4393 10 in in IN cord-028721-x6f26ahr 4393 11 a a DT cord-028721-x6f26ahr 4393 12 patient patient NN cord-028721-x6f26ahr 4393 13 with with IN cord-028721-x6f26ahr 4393 14 the the DT cord-028721-x6f26ahr 4393 15 juvenile juvenile JJ cord-028721-x6f26ahr 4393 16 form form NN cord-028721-x6f26ahr 4393 17 of of IN cord-028721-x6f26ahr 4393 18 hemochromatosis hemochromatosis NN cord-028721-x6f26ahr 4393 19 Polycystic polycystic JJ cord-028721-x6f26ahr 4393 20 kidney kidney NN cord-028721-x6f26ahr 4393 21 disease disease NN cord-028721-x6f26ahr 4393 22 and and CC cord-028721-x6f26ahr 4393 23 infertility infertility NN cord-028721-x6f26ahr 4393 24 : : : cord-028721-x6f26ahr 4393 25 case case NN cord-028721-x6f26ahr 4393 26 report report NN cord-028721-x6f26ahr 4393 27 and and CC cord-028721-x6f26ahr 4393 28 literature literature NN cord-028721-x6f26ahr 4393 29 review review NN cord-028721-x6f26ahr 4393 30 Infertility Infertility NNP cord-028721-x6f26ahr 4393 31 in in IN cord-028721-x6f26ahr 4393 32 adults adult NNS cord-028721-x6f26ahr 4393 33 with with IN cord-028721-x6f26ahr 4393 34 References References NNPS cord-028721-x6f26ahr 4393 35 polycystic polycystic JJ cord-028721-x6f26ahr 4393 36 kidney kidney NN cord-028721-x6f26ahr 4393 37 disease disease NN cord-028721-x6f26ahr 4394 1 Male male JJ cord-028721-x6f26ahr 4394 2 infertility infertility NN cord-028721-x6f26ahr 4394 3 and and CC cord-028721-x6f26ahr 4394 4 adult adult NN cord-028721-x6f26ahr 4394 5 polycystic polycystic JJ cord-028721-x6f26ahr 4394 6 kidney kidney NN cord-028721-x6f26ahr 4394 7 disease disease NN cord-028721-x6f26ahr 4394 8 are be VBP cord-028721-x6f26ahr 4394 9 associated associate VBN cord-028721-x6f26ahr 4394 10 with with IN cord-028721-x6f26ahr 4394 11 necrospermia necrospermia NN cord-028721-x6f26ahr 4394 12 Seminal seminal JJ cord-028721-x6f26ahr 4394 13 vesicle vesicle NN cord-028721-x6f26ahr 4394 14 cysts cyst NNS cord-028721-x6f26ahr 4394 15 and and CC cord-028721-x6f26ahr 4394 16 infertility infertility NN cord-028721-x6f26ahr 4394 17 in in IN cord-028721-x6f26ahr 4394 18 autosomal autosomal JJ cord-028721-x6f26ahr 4394 19 dominant dominant JJ cord-028721-x6f26ahr 4394 20 polycystic polycystic JJ cord-028721-x6f26ahr 4394 21 kidney kidney NN cord-028721-x6f26ahr 4394 22 disease disease NN cord-028721-x6f26ahr 4394 23 Clinical clinical JJ cord-028721-x6f26ahr 4394 24 relevance relevance NN cord-028721-x6f26ahr 4394 25 of of IN cord-028721-x6f26ahr 4394 26 scrotal scrotal JJ cord-028721-x6f26ahr 4394 27 and and CC cord-028721-x6f26ahr 4394 28 transrectal transrectal JJ cord-028721-x6f26ahr 4394 29 ultrasonography ultrasonography NN cord-028721-x6f26ahr 4394 30 in in IN cord-028721-x6f26ahr 4394 31 andrological andrological JJ cord-028721-x6f26ahr 4394 32 patients patient NNS cord-028721-x6f26ahr 4394 33 Testosterone testosterone NN cord-028721-x6f26ahr 4394 34 esters ester NNS cord-028721-x6f26ahr 4394 35 advance advance VBP cord-028721-x6f26ahr 4394 36 skeletal skeletal JJ cord-028721-x6f26ahr 4394 37 maturation maturation NN cord-028721-x6f26ahr 4394 38 more more RBR cord-028721-x6f26ahr 4394 39 than than IN cord-028721-x6f26ahr 4394 40 growth growth NN cord-028721-x6f26ahr 4394 41 in in IN cord-028721-x6f26ahr 4394 42 short short JJ cord-028721-x6f26ahr 4394 43 boys boy NNS cord-028721-x6f26ahr 4394 44 with with IN cord-028721-x6f26ahr 4394 45 chronic chronic JJ cord-028721-x6f26ahr 4394 46 renal renal JJ cord-028721-x6f26ahr 4394 47 failure failure NN cord-028721-x6f26ahr 4394 48 and and CC cord-028721-x6f26ahr 4394 49 delayed delay VBN cord-028721-x6f26ahr 4394 50 puberty puberty NN cord-028721-x6f26ahr 4394 51 Discordant discordant JJ cord-028721-x6f26ahr 4394 52 elevation elevation NN cord-028721-x6f26ahr 4394 53 of of IN cord-028721-x6f26ahr 4394 54 the the DT cord-028721-x6f26ahr 4394 55 common common JJ cord-028721-x6f26ahr 4394 56 alpha alpha NN cord-028721-x6f26ahr 4394 57 subunit subunit NN cord-028721-x6f26ahr 4394 58 of of IN cord-028721-x6f26ahr 4394 59 the the DT cord-028721-x6f26ahr 4394 60 glycoprotein glycoprotein NN cord-028721-x6f26ahr 4394 61 hormones hormone NNS cord-028721-x6f26ahr 4394 62 compared compare VBN cord-028721-x6f26ahr 4394 63 to to IN cord-028721-x6f26ahr 4394 64 β β NN cord-028721-x6f26ahr 4394 65 subunits subunit NNS cord-028721-x6f26ahr 4394 66 in in IN cord-028721-x6f26ahr 4394 67 serum serum NN cord-028721-x6f26ahr 4394 68 of of IN cord-028721-x6f26ahr 4394 69 uremic uremic JJ cord-028721-x6f26ahr 4394 70 patients patient NNS cord-028721-x6f26ahr 4395 1 The the DT cord-028721-x6f26ahr 4395 2 pituitary pituitary JJ cord-028721-x6f26ahr 4395 3 testicular testicular NN cord-028721-x6f26ahr 4395 4 axis axis NN cord-028721-x6f26ahr 4395 5 in in IN cord-028721-x6f26ahr 4395 6 men man NNS cord-028721-x6f26ahr 4395 7 with with IN cord-028721-x6f26ahr 4395 8 chronic chronic JJ cord-028721-x6f26ahr 4395 9 renal renal JJ cord-028721-x6f26ahr 4395 10 failure failure NN cord-028721-x6f26ahr 4395 11 Pathology Pathology NNP cord-028721-x6f26ahr 4395 12 of of IN cord-028721-x6f26ahr 4395 13 endocrine endocrine JJ cord-028721-x6f26ahr 4395 14 organs organ NNS cord-028721-x6f26ahr 4395 15 in in IN cord-028721-x6f26ahr 4395 16 chronic chronic JJ cord-028721-x6f26ahr 4395 17 renal renal JJ cord-028721-x6f26ahr 4395 18 failure failure NN cord-028721-x6f26ahr 4395 19 . . . cord-028721-x6f26ahr 4396 1 An an DT cord-028721-x6f26ahr 4396 2 autopsy autopsy JJ cord-028721-x6f26ahr 4396 3 analysis analysis NN cord-028721-x6f26ahr 4396 4 of of IN cord-028721-x6f26ahr 4396 5 66 66 CD cord-028721-x6f26ahr 4396 6 patients patient NNS cord-028721-x6f26ahr 4396 7 Calcifi Calcifi NNP cord-028721-x6f26ahr 4396 8 cation cation NN cord-028721-x6f26ahr 4396 9 of of IN cord-028721-x6f26ahr 4396 10 the the DT cord-028721-x6f26ahr 4396 11 epididymis epididymis NN cord-028721-x6f26ahr 4396 12 and and CC cord-028721-x6f26ahr 4396 13 the the DT cord-028721-x6f26ahr 4396 14 tunica tunica NNP cord-028721-x6f26ahr 4396 15 albuginea albuginea NNP cord-028721-x6f26ahr 4396 16 of of IN cord-028721-x6f26ahr 4396 17 the the DT cord-028721-x6f26ahr 4396 18 corpora corpora NN cord-028721-x6f26ahr 4396 19 cavernosa cavernosa RB cord-028721-x6f26ahr 4396 20 in in IN cord-028721-x6f26ahr 4396 21 patients patient NNS cord-028721-x6f26ahr 4396 22 on on IN cord-028721-x6f26ahr 4396 23 maintenance maintenance NN cord-028721-x6f26ahr 4396 24 hemodialysis hemodialysis NN cord-028721-x6f26ahr 4396 25 Novel novel JJ cord-028721-x6f26ahr 4396 26 insights insight NNS cord-028721-x6f26ahr 4396 27 into into IN cord-028721-x6f26ahr 4396 28 uremic uremic JJ cord-028721-x6f26ahr 4396 29 vascular vascular JJ cord-028721-x6f26ahr 4396 30 calcifi calcifi NN cord-028721-x6f26ahr 4396 31 cation cation NN cord-028721-x6f26ahr 4396 32 : : : cord-028721-x6f26ahr 4396 33 role role NN cord-028721-x6f26ahr 4396 34 of of IN cord-028721-x6f26ahr 4396 35 matrix matrix NN cord-028721-x6f26ahr 4396 36 Gla Gla NNP cord-028721-x6f26ahr 4396 37 protein protein NN cord-028721-x6f26ahr 4396 38 and and CC cord-028721-x6f26ahr 4396 39 alpha-2-heremans alpha-2-heremans NNP cord-028721-x6f26ahr 4396 40 Schmid Schmid NNP cord-028721-x6f26ahr 4396 41 glycoprotein glycoprotein NN cord-028721-x6f26ahr 4396 42 / / SYM cord-028721-x6f26ahr 4396 43 fetuin fetuin JJ cord-028721-x6f26ahr 4396 44 Cystic cystic JJ cord-028721-x6f26ahr 4396 45 transformation transformation NN cord-028721-x6f26ahr 4396 46 and and CC cord-028721-x6f26ahr 4396 47 calcium calcium NN cord-028721-x6f26ahr 4396 48 oxalate oxalate NN cord-028721-x6f26ahr 4396 49 deposits deposit NNS cord-028721-x6f26ahr 4396 50 in in IN cord-028721-x6f26ahr 4396 51 rete rete NN cord-028721-x6f26ahr 4396 52 testis testis NN cord-028721-x6f26ahr 4396 53 and and CC cord-028721-x6f26ahr 4396 54 efferent efferent JJ cord-028721-x6f26ahr 4396 55 ducts duct NNS cord-028721-x6f26ahr 4396 56 in in IN cord-028721-x6f26ahr 4396 57 dialysis dialysis NN cord-028721-x6f26ahr 4396 58 patients patient NNS cord-028721-x6f26ahr 4396 59 Gonadal Gonadal NNP cord-028721-x6f26ahr 4396 60 dysfunction dysfunction NN cord-028721-x6f26ahr 4396 61 in in IN cord-028721-x6f26ahr 4396 62 uremic uremic JJ cord-028721-x6f26ahr 4396 63 men man NNS cord-028721-x6f26ahr 4396 64 . . . cord-028721-x6f26ahr 4397 1 A a DT cord-028721-x6f26ahr 4397 2 study study NN cord-028721-x6f26ahr 4397 3 of of IN cord-028721-x6f26ahr 4397 4 the the DT cord-028721-x6f26ahr 4397 5 hypothalamo hypothalamo NNP cord-028721-x6f26ahr 4397 6 - - HYPH cord-028721-x6f26ahr 4397 7 pituitarytesticular pituitarytesticular JJ cord-028721-x6f26ahr 4397 8 axis axis NN cord-028721-x6f26ahr 4397 9 before before IN cord-028721-x6f26ahr 4397 10 and and CC cord-028721-x6f26ahr 4397 11 after after IN cord-028721-x6f26ahr 4397 12 renal renal JJ cord-028721-x6f26ahr 4397 13 transplantation transplantation NN cord-028721-x6f26ahr 4397 14 Pathogenesis pathogenesis NN cord-028721-x6f26ahr 4397 15 of of IN cord-028721-x6f26ahr 4397 16 endocrine endocrine JJ cord-028721-x6f26ahr 4397 17 abnormalities abnormality NNS cord-028721-x6f26ahr 4397 18 in in IN cord-028721-x6f26ahr 4397 19 uremia uremia NN cord-028721-x6f26ahr 4397 20 Hypothalamic Hypothalamic NNP cord-028721-x6f26ahr 4397 21 - - HYPH cord-028721-x6f26ahr 4397 22 pituitary pituitary NN cord-028721-x6f26ahr 4397 23 function function NN cord-028721-x6f26ahr 4397 24 in in IN cord-028721-x6f26ahr 4397 25 uremia uremia NN cord-028721-x6f26ahr 4397 26 Zinc Zinc NNP cord-028721-x6f26ahr 4397 27 defi defi NN cord-028721-x6f26ahr 4397 28 ciency ciency NN cord-028721-x6f26ahr 4397 29 in in IN cord-028721-x6f26ahr 4397 30 men man NNS cord-028721-x6f26ahr 4397 31 with with IN cord-028721-x6f26ahr 4397 32 Crohn Crohn NNP cord-028721-x6f26ahr 4397 33 's 's POS cord-028721-x6f26ahr 4397 34 disease disease NN cord-028721-x6f26ahr 4397 35 may may MD cord-028721-x6f26ahr 4397 36 contribute contribute VB cord-028721-x6f26ahr 4397 37 to to IN cord-028721-x6f26ahr 4397 38 poor poor JJ cord-028721-x6f26ahr 4397 39 sperm sperm NN cord-028721-x6f26ahr 4397 40 function function NN cord-028721-x6f26ahr 4397 41 and and CC cord-028721-x6f26ahr 4397 42 male male JJ cord-028721-x6f26ahr 4397 43 infertility infertility NN cord-028721-x6f26ahr 4397 44 Sperm sperm NN cord-028721-x6f26ahr 4397 45 nucleomalacia nucleomalacia NNS cord-028721-x6f26ahr 4397 46 in in IN cord-028721-x6f26ahr 4397 47 men man NNS cord-028721-x6f26ahr 4397 48 with with IN cord-028721-x6f26ahr 4397 49 infl infl NN cord-028721-x6f26ahr 4397 50 amatory amatory JJ cord-028721-x6f26ahr 4397 51 bowel bowel NN cord-028721-x6f26ahr 4397 52 disease disease NN cord-028721-x6f26ahr 4398 1 The the DT cord-028721-x6f26ahr 4398 2 effects effect NNS cord-028721-x6f26ahr 4398 3 of of IN cord-028721-x6f26ahr 4398 4 sulphasalazine sulphasalazine NN cord-028721-x6f26ahr 4398 5 on on IN cord-028721-x6f26ahr 4398 6 human human JJ cord-028721-x6f26ahr 4398 7 male male JJ cord-028721-x6f26ahr 4398 8 fertility fertility NN cord-028721-x6f26ahr 4398 9 potencial potencial JJ cord-028721-x6f26ahr 4398 10 and and CC cord-028721-x6f26ahr 4398 11 seminal seminal JJ cord-028721-x6f26ahr 4398 12 prostaglandins prostaglandin NNS cord-028721-x6f26ahr 4399 1 Mesalazineinduced mesalazineinduced JJ cord-028721-x6f26ahr 4399 2 reversible reversible JJ cord-028721-x6f26ahr 4399 3 infertility infertility NN cord-028721-x6f26ahr 4399 4 in in IN cord-028721-x6f26ahr 4399 5 a a DT cord-028721-x6f26ahr 4399 6 young young JJ cord-028721-x6f26ahr 4399 7 male male NN cord-028721-x6f26ahr 4399 8 Sulphasalazine Sulphasalazine NNP cord-028721-x6f26ahr 4399 9 and and CC cord-028721-x6f26ahr 4399 10 5-aminosalicylic 5-aminosalicylic CD cord-028721-x6f26ahr 4399 11 acid acid NN cord-028721-x6f26ahr 4399 12 in in IN cord-028721-x6f26ahr 4399 13 long long JJ cord-028721-x6f26ahr 4399 14 - - HYPH cord-028721-x6f26ahr 4399 15 term term NN cord-028721-x6f26ahr 4399 16 treatment treatment NN cord-028721-x6f26ahr 4399 17 of of IN cord-028721-x6f26ahr 4399 18 ulcerative ulcerative JJ cord-028721-x6f26ahr 4399 19 colitis colitis NN cord-028721-x6f26ahr 4399 20 : : : cord-028721-x6f26ahr 4399 21 report report VB cord-028721-x6f26ahr 4399 22 on on IN cord-028721-x6f26ahr 4399 23 tolerance tolerance NN cord-028721-x6f26ahr 4399 24 and and CC cord-028721-x6f26ahr 4399 25 side side NN cord-028721-x6f26ahr 4399 26 - - HYPH cord-028721-x6f26ahr 4399 27 effects effect NNS cord-028721-x6f26ahr 4399 28 Testosterone testosterone NN cord-028721-x6f26ahr 4399 29 replacement replacement NN cord-028721-x6f26ahr 4399 30 for for IN cord-028721-x6f26ahr 4399 31 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4399 32 : : : cord-028721-x6f26ahr 4399 33 clinical clinical JJ cord-028721-x6f26ahr 4399 34 fi fi NN cord-028721-x6f26ahr 4399 35 ndings nding NNS cord-028721-x6f26ahr 4399 36 and and CC cord-028721-x6f26ahr 4399 37 best good JJS cord-028721-x6f26ahr 4399 38 practices practice NNS cord-028721-x6f26ahr 4399 39 HIV HIV NNP cord-028721-x6f26ahr 4399 40 - - HYPH cord-028721-x6f26ahr 4399 41 associated associate VBN cord-028721-x6f26ahr 4399 42 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4399 43 Hypogonadism Hypogonadism NNP cord-028721-x6f26ahr 4399 44 and and CC cord-028721-x6f26ahr 4399 45 wasting waste VBG cord-028721-x6f26ahr 4399 46 in in IN cord-028721-x6f26ahr 4399 47 the the DT cord-028721-x6f26ahr 4399 48 era era NN cord-028721-x6f26ahr 4399 49 of of IN cord-028721-x6f26ahr 4399 50 HAART HAART NNP cord-028721-x6f26ahr 4399 51 in in IN cord-028721-x6f26ahr 4399 52 HIV HIV NNP cord-028721-x6f26ahr 4399 53 - - HYPH cord-028721-x6f26ahr 4399 54 infected infect VBN cord-028721-x6f26ahr 4399 55 patients patient NNS cord-028721-x6f26ahr 4399 56 Prevalence prevalence NN cord-028721-x6f26ahr 4399 57 of of IN cord-028721-x6f26ahr 4399 58 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4399 59 among among IN cord-028721-x6f26ahr 4399 60 men man NNS cord-028721-x6f26ahr 4399 61 with with IN cord-028721-x6f26ahr 4399 62 weight weight NN cord-028721-x6f26ahr 4399 63 loss loss NN cord-028721-x6f26ahr 4399 64 related relate VBN cord-028721-x6f26ahr 4399 65 to to IN cord-028721-x6f26ahr 4399 66 human human JJ cord-028721-x6f26ahr 4399 67 immunodefi immunodefi NNP cord-028721-x6f26ahr 4399 68 ciency ciency NNP cord-028721-x6f26ahr 4399 69 virus virus NN cord-028721-x6f26ahr 4399 70 infection infection NN cord-028721-x6f26ahr 4399 71 who who WP cord-028721-x6f26ahr 4399 72 were be VBD cord-028721-x6f26ahr 4399 73 receiving receive VBG cord-028721-x6f26ahr 4399 74 highly highly RB cord-028721-x6f26ahr 4399 75 active active JJ cord-028721-x6f26ahr 4399 76 antiretroviral antiretroviral JJ cord-028721-x6f26ahr 4399 77 therapy therapy NN cord-028721-x6f26ahr 4399 78 Loss Loss NNP cord-028721-x6f26ahr 4399 79 of of IN cord-028721-x6f26ahr 4399 80 lean lean JJ cord-028721-x6f26ahr 4399 81 body body NN cord-028721-x6f26ahr 4399 82 mass mass NN cord-028721-x6f26ahr 4399 83 and and CC cord-028721-x6f26ahr 4399 84 muscle muscle NN cord-028721-x6f26ahr 4399 85 mass mass NN cord-028721-x6f26ahr 4399 86 correlates correlate VBZ cord-028721-x6f26ahr 4399 87 with with IN cord-028721-x6f26ahr 4399 88 androgen androgen NN cord-028721-x6f26ahr 4399 89 levels level NNS cord-028721-x6f26ahr 4399 90 in in IN cord-028721-x6f26ahr 4399 91 hypogonadal hypogonadal JJ cord-028721-x6f26ahr 4399 92 men man NNS cord-028721-x6f26ahr 4399 93 with with IN cord-028721-x6f26ahr 4399 94 acquired acquire VBN cord-028721-x6f26ahr 4399 95 immunodefi immunodefi NNP cord-028721-x6f26ahr 4399 96 ciency ciency NNP cord-028721-x6f26ahr 4399 97 syndrome syndrome NN cord-028721-x6f26ahr 4399 98 and and CC cord-028721-x6f26ahr 4399 99 wasting waste VBG cord-028721-x6f26ahr 4399 100 Effects effect NNS cord-028721-x6f26ahr 4399 101 of of IN cord-028721-x6f26ahr 4399 102 hypogonadism hypogonadism NN cord-028721-x6f26ahr 4399 103 and and CC cord-028721-x6f26ahr 4399 104 testosterone testosterone NN cord-028721-x6f26ahr 4399 105 administration administration NN cord-028721-x6f26ahr 4399 106 on on IN cord-028721-x6f26ahr 4399 107 depression depression NN cord-028721-x6f26ahr 4399 108 indices index NNS cord-028721-x6f26ahr 4399 109 in in IN cord-028721-x6f26ahr 4399 110 HIV HIV NNP cord-028721-x6f26ahr 4399 111 - - HYPH cord-028721-x6f26ahr 4399 112 infected infect VBN cord-028721-x6f26ahr 4399 113 men man NNS cord-028721-x6f26ahr 4399 114 Gonadal Gonadal NNP cord-028721-x6f26ahr 4399 115 hormone hormone NN cord-028721-x6f26ahr 4399 116 levels level NNS cord-028721-x6f26ahr 4399 117 in in IN cord-028721-x6f26ahr 4399 118 injection injection NN cord-028721-x6f26ahr 4399 119 drug drug NN cord-028721-x6f26ahr 4399 120 users user NNS cord-028721-x6f26ahr 4399 121 Endocrine endocrine JJ cord-028721-x6f26ahr 4399 122 disorders disorder NNS cord-028721-x6f26ahr 4399 123 in in IN cord-028721-x6f26ahr 4399 124 men man NNS cord-028721-x6f26ahr 4399 125 infected infect VBN cord-028721-x6f26ahr 4399 126 with with IN cord-028721-x6f26ahr 4399 127 human human JJ cord-028721-x6f26ahr 4399 128 immunodefi immunodefi NNP cord-028721-x6f26ahr 4399 129 ciency ciency NNP cord-028721-x6f26ahr 4399 130 virus virus NN cord-028721-x6f26ahr 4399 131 Testicular testicular JJ cord-028721-x6f26ahr 4399 132 pathologic pathologic JJ cord-028721-x6f26ahr 4399 133 changes change NNS cord-028721-x6f26ahr 4399 134 and and CC cord-028721-x6f26ahr 4399 135 the the DT cord-028721-x6f26ahr 4399 136 pituitary pituitary JJ cord-028721-x6f26ahr 4399 137 - - HYPH cord-028721-x6f26ahr 4399 138 testicular testicular NN cord-028721-x6f26ahr 4399 139 axis axis NN cord-028721-x6f26ahr 4399 140 during during IN cord-028721-x6f26ahr 4399 141 human human JJ cord-028721-x6f26ahr 4399 142 immunodefi immunodefi NNP cord-028721-x6f26ahr 4399 143 ciency ciency NNP cord-028721-x6f26ahr 4399 144 virus virus NN cord-028721-x6f26ahr 4399 145 infection infection NN cord-028721-x6f26ahr 4399 146 Adrenal adrenal JJ cord-028721-x6f26ahr 4399 147 and and CC cord-028721-x6f26ahr 4399 148 testicular testicular JJ cord-028721-x6f26ahr 4399 149 function function NN cord-028721-x6f26ahr 4399 150 in in IN cord-028721-x6f26ahr 4399 151 boys boy NNS cord-028721-x6f26ahr 4399 152 affected affect VBN cord-028721-x6f26ahr 4399 153 by by IN cord-028721-x6f26ahr 4399 154 thalassemia thalassemia NN cord-028721-x6f26ahr 4399 155 Italian Italian NNP cord-028721-x6f26ahr 4399 156 Working Working NNP cord-028721-x6f26ahr 4399 157 Group Group NNP cord-028721-x6f26ahr 4399 158 on on IN cord-028721-x6f26ahr 4399 159 Endocrine Endocrine NNP cord-028721-x6f26ahr 4399 160 Complications Complications NNPS cord-028721-x6f26ahr 4399 161 in in IN cord-028721-x6f26ahr 4399 162 Non non JJ cord-028721-x6f26ahr 4399 163 - - JJ cord-028721-x6f26ahr 4399 164 Endocrine endocrine JJ cord-028721-x6f26ahr 4399 165 Diseases disease NNS cord-028721-x6f26ahr 4399 166 . . . cord-028721-x6f26ahr 4400 1 Impact impact NN cord-028721-x6f26ahr 4400 2 of of IN cord-028721-x6f26ahr 4400 3 long long JJ cord-028721-x6f26ahr 4400 4 - - HYPH cord-028721-x6f26ahr 4400 5 term term NN cord-028721-x6f26ahr 4400 6 iron iron NN cord-028721-x6f26ahr 4400 7 chelation chelation NN cord-028721-x6f26ahr 4400 8 therapy therapy NN cord-028721-x6f26ahr 4400 9 on on IN cord-028721-x6f26ahr 4400 10 growth growth NN cord-028721-x6f26ahr 4400 11 and and CC cord-028721-x6f26ahr 4400 12 endocrine endocrine JJ cord-028721-x6f26ahr 4400 13 functions function NNS cord-028721-x6f26ahr 4400 14 in in IN cord-028721-x6f26ahr 4400 15 thalassaemia thalassaemia NNP cord-028721-x6f26ahr 4400 16 Pubertal Pubertal NNP cord-028721-x6f26ahr 4400 17 evaluation evaluation NN cord-028721-x6f26ahr 4400 18 of of IN cord-028721-x6f26ahr 4400 19 adolescent adolescent JJ cord-028721-x6f26ahr 4400 20 boys boy NNS cord-028721-x6f26ahr 4400 21 with with IN cord-028721-x6f26ahr 4400 22 β β NN cord-028721-x6f26ahr 4400 23 - - HYPH cord-028721-x6f26ahr 4400 24 thalassemia thalassemia NN cord-028721-x6f26ahr 4400 25 major major NN cord-028721-x6f26ahr 4400 26 and and CC cord-028721-x6f26ahr 4400 27 delayed delay VBN cord-028721-x6f26ahr 4400 28 puberty puberty NN cord-028721-x6f26ahr 4400 29 Prevalence prevalence NN cord-028721-x6f26ahr 4400 30 of of IN cord-028721-x6f26ahr 4400 31 growth growth NN cord-028721-x6f26ahr 4400 32 and and CC cord-028721-x6f26ahr 4400 33 puberty puberty NN cord-028721-x6f26ahr 4400 34 failure failure NN cord-028721-x6f26ahr 4400 35 with with IN cord-028721-x6f26ahr 4400 36 respect respect NN cord-028721-x6f26ahr 4400 37 to to IN cord-028721-x6f26ahr 4400 38 growth growth NN cord-028721-x6f26ahr 4400 39 hormone hormone NN cord-028721-x6f26ahr 4400 40 and and CC cord-028721-x6f26ahr 4400 41 gonadotropins gonadotropins NNP cord-028721-x6f26ahr 4400 42 secretion secretion NN cord-028721-x6f26ahr 4400 43 in in IN cord-028721-x6f26ahr 4400 44 βthalassemia βthalassemia NNP cord-028721-x6f26ahr 4400 45 major major JJ cord-028721-x6f26ahr 4400 46 Growth Growth NNP cord-028721-x6f26ahr 4400 47 and and CC cord-028721-x6f26ahr 4400 48 puberty puberty NN cord-028721-x6f26ahr 4400 49 and and CC cord-028721-x6f26ahr 4400 50 its -PRON- PRP$ cord-028721-x6f26ahr 4400 51 management management NN cord-028721-x6f26ahr 4400 52 in in IN cord-028721-x6f26ahr 4400 53 thalassaemia thalassaemia NN cord-028721-x6f26ahr 4400 54 Spontaneous Spontaneous NNP cord-028721-x6f26ahr 4400 55 and and CC cord-028721-x6f26ahr 4400 56 GnRHprovoked gnrhprovoke VBD cord-028721-x6f26ahr 4400 57 gonadotropin gonadotropin JJ cord-028721-x6f26ahr 4400 58 secretion secretion NN cord-028721-x6f26ahr 4400 59 and and CC cord-028721-x6f26ahr 4400 60 testosterone testosterone NN cord-028721-x6f26ahr 4400 61 response response NN cord-028721-x6f26ahr 4400 62 to to IN cord-028721-x6f26ahr 4400 63 human human JJ cord-028721-x6f26ahr 4400 64 chorionic chorionic JJ cord-028721-x6f26ahr 4400 65 gonadotropin gonadotropin NN cord-028721-x6f26ahr 4400 66 in in IN cord-028721-x6f26ahr 4400 67 adolescent adolescent JJ cord-028721-x6f26ahr 4400 68 boys boy NNS cord-028721-x6f26ahr 4400 69 with with IN cord-028721-x6f26ahr 4400 70 thalassaemia thalassaemia NN cord-028721-x6f26ahr 4400 71 major major JJ cord-028721-x6f26ahr 4400 72 and and CC cord-028721-x6f26ahr 4400 73 delayed delay VBN cord-028721-x6f26ahr 4400 74 puberty puberty NN cord-028721-x6f26ahr 4401 1 Inhibin Inhibin NNP cord-028721-x6f26ahr 4401 2 B B NNP cord-028721-x6f26ahr 4401 3 in in IN cord-028721-x6f26ahr 4401 4 men man NNS cord-028721-x6f26ahr 4401 5 with with IN cord-028721-x6f26ahr 4401 6 severe severe JJ cord-028721-x6f26ahr 4401 7 obesity obesity NN cord-028721-x6f26ahr 4401 8 and and CC cord-028721-x6f26ahr 4401 9 after after IN cord-028721-x6f26ahr 4401 10 weight weight NN cord-028721-x6f26ahr 4401 11 reduction reduction NN cord-028721-x6f26ahr 4401 12 following follow VBG cord-028721-x6f26ahr 4401 13 gastroplasty gastroplasty NNP cord-028721-x6f26ahr 4401 14 Obesity obesity NN cord-028721-x6f26ahr 4401 15 and and CC cord-028721-x6f26ahr 4401 16 reproductive reproductive JJ cord-028721-x6f26ahr 4401 17 disorders disorder NNS cord-028721-x6f26ahr 4401 18 : : : cord-028721-x6f26ahr 4401 19 a a DT cord-028721-x6f26ahr 4401 20 review review NN cord-028721-x6f26ahr 4401 21 Obesity obesity NN cord-028721-x6f26ahr 4401 22 , , , cord-028721-x6f26ahr 4401 23 fat fat JJ cord-028721-x6f26ahr 4401 24 distribution distribution NN cord-028721-x6f26ahr 4401 25 and and CC cord-028721-x6f26ahr 4401 26 infertility infertility NN cord-028721-x6f26ahr 4401 27 Mutational Mutational NNP cord-028721-x6f26ahr 4402 1 analysis analysis NN cord-028721-x6f26ahr 4402 2 of of IN cord-028721-x6f26ahr 4402 3 the the DT cord-028721-x6f26ahr 4402 4 autoimmune autoimmune JJ cord-028721-x6f26ahr 4402 5 regulator regulator NN cord-028721-x6f26ahr 4402 6 ( ( -LRB- cord-028721-x6f26ahr 4402 7 AIRE AIRE NNP cord-028721-x6f26ahr 4402 8 ) ) -RRB- cord-028721-x6f26ahr 4402 9 gene gene NN cord-028721-x6f26ahr 4402 10 in in IN cord-028721-x6f26ahr 4402 11 sporadic sporadic JJ cord-028721-x6f26ahr 4402 12 autoimmune autoimmune JJ cord-028721-x6f26ahr 4402 13 Addison Addison NNP cord-028721-x6f26ahr 4402 14 's 's POS cord-028721-x6f26ahr 4402 15 disease disease NN cord-028721-x6f26ahr 4402 16 can can MD cord-028721-x6f26ahr 4402 17 reveal reveal VB cord-028721-x6f26ahr 4402 18 patients patient NNS cord-028721-x6f26ahr 4402 19 with with IN cord-028721-x6f26ahr 4402 20 unidentifi unidentifi NNP cord-028721-x6f26ahr 4402 21 ed ed NNP cord-028721-x6f26ahr 4402 22 autoimmune autoimmune NNP cord-028721-x6f26ahr 4402 23 polyendocrine polyendocrine NNP cord-028721-x6f26ahr 4402 24 syndrome syndrome NN cord-028721-x6f26ahr 4402 25 type type NN cord-028721-x6f26ahr 4402 26 l l NNP cord-028721-x6f26ahr 4402 27 Autoimmune Autoimmune NNP cord-028721-x6f26ahr 4402 28 regulator regulator NN cord-028721-x6f26ahr 4402 29 ( ( -LRB- cord-028721-x6f26ahr 4402 30 AIRE AIRE NNP cord-028721-x6f26ahr 4402 31 ) ) -RRB- cord-028721-x6f26ahr 4402 32 gene gene NN cord-028721-x6f26ahr 4402 33 on on IN cord-028721-x6f26ahr 4402 34 chromosome chromosome NN cord-028721-x6f26ahr 4402 35 21 21 CD cord-028721-x6f26ahr 4402 36 : : : cord-028721-x6f26ahr 4402 37 implications implication NNS cord-028721-x6f26ahr 4402 38 for for IN cord-028721-x6f26ahr 4402 39 autoimmune autoimmune JJ cord-028721-x6f26ahr 4402 40 polyendocrinopathycandidiasis polyendocrinopathycandidiasis NN cord-028721-x6f26ahr 4402 41 - - HYPH cord-028721-x6f26ahr 4402 42 ectodermal ectodermal NN cord-028721-x6f26ahr 4402 43 dystrophy dystrophy NN cord-028721-x6f26ahr 4402 44 ( ( -LRB- cord-028721-x6f26ahr 4402 45 APECED APECED NNP cord-028721-x6f26ahr 4402 46 ) ) -RRB- cord-028721-x6f26ahr 4403 1 any any DT cord-028721-x6f26ahr 4403 2 more more RBR cord-028721-x6f26ahr 4403 3 common common JJ cord-028721-x6f26ahr 4403 4 manifestations manifestation NNS cord-028721-x6f26ahr 4403 5 of of IN cord-028721-x6f26ahr 4403 6 endocrine endocrine JJ cord-028721-x6f26ahr 4403 7 autoimmunity autoimmunity NN cord-028721-x6f26ahr 4403 8 Adrenal adrenal JJ cord-028721-x6f26ahr 4403 9 and and CC cord-028721-x6f26ahr 4403 10 gonadal gonadal JJ cord-028721-x6f26ahr 4403 11 autoimmune autoimmune JJ cord-028721-x6f26ahr 4403 12 diseases disease NNS cord-028721-x6f26ahr 4403 13 Identifi Identifi NNP cord-028721-x6f26ahr 4403 14 cation cation NN cord-028721-x6f26ahr 4403 15 by by IN cord-028721-x6f26ahr 4403 16 molecular molecular JJ cord-028721-x6f26ahr 4403 17 cloning cloning NN cord-028721-x6f26ahr 4403 18 of of IN cord-028721-x6f26ahr 4403 19 an an DT cord-028721-x6f26ahr 4403 20 autoantigen autoantigen NN cord-028721-x6f26ahr 4403 21 associated associate VBN cord-028721-x6f26ahr 4403 22 with with IN cord-028721-x6f26ahr 4403 23 Addison Addison NNP cord-028721-x6f26ahr 4403 24 's 's POS cord-028721-x6f26ahr 4403 25 disease disease NN cord-028721-x6f26ahr 4403 26 as as IN cord-028721-x6f26ahr 4403 27 steroid steroid NN cord-028721-x6f26ahr 4403 28 17 17 CD cord-028721-x6f26ahr 4403 29 alphahydroxylase alphahydroxylase NN cord-028721-x6f26ahr 4404 1 Two two CD cord-028721-x6f26ahr 4404 2 different different JJ cord-028721-x6f26ahr 4404 3 cytochrome cytochrome NN cord-028721-x6f26ahr 4404 4 p450 p450 NN cord-028721-x6f26ahr 4404 5 enzymes enzyme NNS cord-028721-x6f26ahr 4404 6 are be VBP cord-028721-x6f26ahr 4404 7 the the DT cord-028721-x6f26ahr 4404 8 adrenal adrenal JJ cord-028721-x6f26ahr 4404 9 antigens antigen NNS cord-028721-x6f26ahr 4404 10 in in IN cord-028721-x6f26ahr 4404 11 autoimmune autoimmune JJ cord-028721-x6f26ahr 4404 12 polyendocrine polyendocrine NN cord-028721-x6f26ahr 4404 13 syndrome syndrome NN cord-028721-x6f26ahr 4404 14 type type NN cord-028721-x6f26ahr 4404 15 I I NNP cord-028721-x6f26ahr 4404 16 and and CC cord-028721-x6f26ahr 4404 17 Addison Addison NNP cord-028721-x6f26ahr 4404 18 's 's POS cord-028721-x6f26ahr 4404 19 disease disease NN cord-028721-x6f26ahr 4404 20 Prevalence prevalence NN cord-028721-x6f26ahr 4404 21 and and CC cord-028721-x6f26ahr 4404 22 clinical clinical JJ cord-028721-x6f26ahr 4404 23 associations association NNS cord-028721-x6f26ahr 4404 24 of of IN cord-028721-x6f26ahr 4404 25 10 10 CD cord-028721-x6f26ahr 4404 26 defi defi NNP cord-028721-x6f26ahr 4404 27 ned ned NNP cord-028721-x6f26ahr 4404 28 autoantibodies autoantibody NNS cord-028721-x6f26ahr 4404 29 in in IN cord-028721-x6f26ahr 4404 30 autoimmune autoimmune JJ cord-028721-x6f26ahr 4404 31 polyendocrine polyendocrine NN cord-028721-x6f26ahr 4404 32 syndrome syndrome NN cord-028721-x6f26ahr 4404 33 type type NN cord-028721-x6f26ahr 4405 1 I -PRON- PRP cord-028721-x6f26ahr 4405 2 Polyglandular Polyglandular NNP cord-028721-x6f26ahr 4406 1 autoinmune autoinmune NNP cord-028721-x6f26ahr 4406 2 syndromes syndromes NNPS cord-028721-x6f26ahr 4407 1 Isolated isolated JJ cord-028721-x6f26ahr 4407 2 gonadotrope gonadotrope NN cord-028721-x6f26ahr 4407 3 failure failure NN cord-028721-x6f26ahr 4407 4 in in IN cord-028721-x6f26ahr 4407 5 the the DT cord-028721-x6f26ahr 4407 6 polyglandular polyglandular NNP cord-028721-x6f26ahr 4407 7 autoimmune autoimmune NNP cord-028721-x6f26ahr 4407 8 syndrome syndrome NN cord-028721-x6f26ahr 4407 9 Endocrine Endocrine NNP cord-028721-x6f26ahr 4407 10 dysfunction dysfunction NN cord-028721-x6f26ahr 4407 11 in in IN cord-028721-x6f26ahr 4407 12 patients patient NNS cord-028721-x6f26ahr 4407 13 with with IN cord-028721-x6f26ahr 4407 14 Fabry Fabry NNP cord-028721-x6f26ahr 4407 15 disease disease NN cord-028721-x6f26ahr 4407 16 Testicular Testicular NNP cord-028721-x6f26ahr 4407 17 and and CC cord-028721-x6f26ahr 4407 18 epididymal epididymal JJ cord-028721-x6f26ahr 4407 19 involvement involvement NN cord-028721-x6f26ahr 4407 20 in in IN cord-028721-x6f26ahr 4407 21 Fabry Fabry NNP cord-028721-x6f26ahr 4407 22 's 's POS cord-028721-x6f26ahr 4407 23 disease disease NN cord-028721-x6f26ahr 4407 24 Safety Safety NNP cord-028721-x6f26ahr 4407 25 and and CC cord-028721-x6f26ahr 4407 26 effi effi NNP cord-028721-x6f26ahr 4407 27 cacy cacy NNP cord-028721-x6f26ahr 4407 28 of of IN cord-028721-x6f26ahr 4407 29 recombinant recombinant JJ cord-028721-x6f26ahr 4407 30 human human JJ cord-028721-x6f26ahr 4407 31 alpha alpha NN cord-028721-x6f26ahr 4407 32 - - HYPH cord-028721-x6f26ahr 4407 33 galactosidase galactosidase NN cord-028721-x6f26ahr 4407 34 A a DT cord-028721-x6f26ahr 4407 35 replacement replacement NN cord-028721-x6f26ahr 4407 36 therapy therapy NN cord-028721-x6f26ahr 4407 37 in in IN cord-028721-x6f26ahr 4407 38 Fabry Fabry NNP cord-028721-x6f26ahr 4407 39 's 's POS cord-028721-x6f26ahr 4407 40 disease disease NN cord-028721-x6f26ahr 4407 41 Fabry Fabry NNP cord-028721-x6f26ahr 4407 42 disease disease NN cord-028721-x6f26ahr 4407 43 , , , cord-028721-x6f26ahr 4407 44 an an DT cord-028721-x6f26ahr 4407 45 underrecognized underrecognize VBN cord-028721-x6f26ahr 4407 46 multisystemic multisystemic JJ cord-028721-x6f26ahr 4407 47 disorder disorder NN cord-028721-x6f26ahr 4407 48 : : : cord-028721-x6f26ahr 4408 1 expert expert JJ cord-028721-x6f26ahr 4408 2 recommendations recommendation NNS cord-028721-x6f26ahr 4408 3 for for IN cord-028721-x6f26ahr 4408 4 diagnosis diagnosis NN cord-028721-x6f26ahr 4408 5 , , , cord-028721-x6f26ahr 4408 6 management management NN cord-028721-x6f26ahr 4408 7 , , , cord-028721-x6f26ahr 4408 8 and and CC cord-028721-x6f26ahr 4408 9 enzyme enzyme NN cord-028721-x6f26ahr 4408 10 replacement replacement NN cord-028721-x6f26ahr 4408 11 therapy therapy NN cord-028721-x6f26ahr 4408 12 Enzyme enzyme NN cord-028721-x6f26ahr 4408 13 replacement replacement NN cord-028721-x6f26ahr 4408 14 therapy therapy NN cord-028721-x6f26ahr 4408 15 and and CC cord-028721-x6f26ahr 4408 16 renal renal JJ cord-028721-x6f26ahr 4408 17 function function NN cord-028721-x6f26ahr 4408 18 in in IN cord-028721-x6f26ahr 4408 19 201 201 CD cord-028721-x6f26ahr 4408 20 patients patient NNS cord-028721-x6f26ahr 4408 21 with with IN cord-028721-x6f26ahr 4408 22 Fabry Fabry NNP cord-028721-x6f26ahr 4408 23 disease disease NN cord-028721-x6f26ahr 4408 24 Putative Putative NNP cord-028721-x6f26ahr 4408 25 X X NNP cord-028721-x6f26ahr 4408 26 - - HYPH cord-028721-x6f26ahr 4408 27 linked link VBN cord-028721-x6f26ahr 4408 28 adrenoleukodystrophy adrenoleukodystrophy NN cord-028721-x6f26ahr 4408 29 gene gene NN cord-028721-x6f26ahr 4408 30 shares share VBZ cord-028721-x6f26ahr 4408 31 unexpected unexpected JJ cord-028721-x6f26ahr 4408 32 homology homology NN cord-028721-x6f26ahr 4408 33 with with IN cord-028721-x6f26ahr 4408 34 ABC ABC NNP cord-028721-x6f26ahr 4408 35 transporters transporter NNS cord-028721-x6f26ahr 4408 36 Gonadal Gonadal NNP cord-028721-x6f26ahr 4408 37 mosaicism mosaicism NN cord-028721-x6f26ahr 4408 38 in in IN cord-028721-x6f26ahr 4408 39 a a DT cord-028721-x6f26ahr 4408 40 family family NN cord-028721-x6f26ahr 4408 41 with with IN cord-028721-x6f26ahr 4408 42 adreno adreno NNP cord-028721-x6f26ahr 4408 43 - - HYPH cord-028721-x6f26ahr 4408 44 leukodystrophy leukodystrophy NNP cord-028721-x6f26ahr 4408 45 . . . cord-028721-x6f26ahr 4409 1 Molecular molecular JJ cord-028721-x6f26ahr 4409 2 diagnosis diagnosis NN cord-028721-x6f26ahr 4409 3 of of IN cord-028721-x6f26ahr 4409 4 carrier carrier NN cord-028721-x6f26ahr 4409 5 status status NN cord-028721-x6f26ahr 4409 6 among among IN cord-028721-x6f26ahr 4409 7 daughters daughter NNS cord-028721-x6f26ahr 4409 8 of of IN cord-028721-x6f26ahr 4409 9 a a DT cord-028721-x6f26ahr 4409 10 gonadal gonadal JJ cord-028721-x6f26ahr 4409 11 mosaic mosaic NN cord-028721-x6f26ahr 4409 12 when when WRB cord-028721-x6f26ahr 4409 13 direct direct JJ cord-028721-x6f26ahr 4409 14 detection detection NN cord-028721-x6f26ahr 4409 15 of of IN cord-028721-x6f26ahr 4409 16 the the DT cord-028721-x6f26ahr 4409 17 mutation mutation NN cord-028721-x6f26ahr 4409 18 is be VBZ cord-028721-x6f26ahr 4409 19 not not RB cord-028721-x6f26ahr 4409 20 possible possible JJ cord-028721-x6f26ahr 4409 21 X x NN cord-028721-x6f26ahr 4409 22 - - HYPH cord-028721-x6f26ahr 4409 23 linked link VBN cord-028721-x6f26ahr 4409 24 adrenoleukodystrophy adrenoleukodystrophy NN cord-028721-x6f26ahr 4409 25 : : : cord-028721-x6f26ahr 4409 26 role role NN cord-028721-x6f26ahr 4409 27 of of IN cord-028721-x6f26ahr 4409 28 very very RB cord-028721-x6f26ahr 4409 29 long long JJ cord-028721-x6f26ahr 4409 30 - - HYPH cord-028721-x6f26ahr 4409 31 chain chain NN cord-028721-x6f26ahr 4409 32 acyl acyl NN cord-028721-x6f26ahr 4409 33 - - HYPH cord-028721-x6f26ahr 4409 34 CoA coa NN cord-028721-x6f26ahr 4409 35 synthetases synthetase NNS cord-028721-x6f26ahr 4409 36 Adrenal Adrenal NNP cord-028721-x6f26ahr 4409 37 and and CC cord-028721-x6f26ahr 4409 38 testicular testicular JJ cord-028721-x6f26ahr 4409 39 function function NN cord-028721-x6f26ahr 4409 40 in in IN cord-028721-x6f26ahr 4409 41 14 14 CD cord-028721-x6f26ahr 4409 42 patients patient NNS cord-028721-x6f26ahr 4409 43 with with IN cord-028721-x6f26ahr 4409 44 adrenoleukodystrophy adrenoleukodystrophy NN cord-028721-x6f26ahr 4409 45 or or CC cord-028721-x6f26ahr 4409 46 adrenomyeloneuropathy adrenomyeloneuropathy NNP cord-028721-x6f26ahr 4410 1 The the DT cord-028721-x6f26ahr 4410 2 testis testis NN cord-028721-x6f26ahr 4410 3 in in IN cord-028721-x6f26ahr 4410 4 adreno adreno NNP cord-028721-x6f26ahr 4410 5 - - HYPH cord-028721-x6f26ahr 4410 6 leukodystrophy leukodystrophy NNP cord-028721-x6f26ahr 4411 1 In in IN cord-028721-x6f26ahr 4411 2 situ situ JJ cord-028721-x6f26ahr 4411 3 localization localization NN cord-028721-x6f26ahr 4411 4 of of IN cord-028721-x6f26ahr 4411 5 the the DT cord-028721-x6f26ahr 4411 6 genetic genetic JJ cord-028721-x6f26ahr 4411 7 locus locus NN cord-028721-x6f26ahr 4411 8 encoding encode VBG cord-028721-x6f26ahr 4411 9 the the DT cord-028721-x6f26ahr 4411 10 lysosomal lysosomal JJ cord-028721-x6f26ahr 4411 11 acid acid NN cord-028721-x6f26ahr 4411 12 lipase lipase NN cord-028721-x6f26ahr 4411 13 / / SYM cord-028721-x6f26ahr 4411 14 cholesteryl cholesteryl NN cord-028721-x6f26ahr 4411 15 esterase esterase NN cord-028721-x6f26ahr 4411 16 ( ( -LRB- cord-028721-x6f26ahr 4411 17 LIPA LIPA NNP cord-028721-x6f26ahr 4411 18 ) ) -RRB- cord-028721-x6f26ahr 4411 19 defi defi NNP cord-028721-x6f26ahr 4411 20 cient cient NN cord-028721-x6f26ahr 4411 21 in in IN cord-028721-x6f26ahr 4411 22 Wolman Wolman NNP cord-028721-x6f26ahr 4411 23 disease disease NN cord-028721-x6f26ahr 4411 24 to to IN cord-028721-x6f26ahr 4411 25 chromosome chromosome NN cord-028721-x6f26ahr 4412 1 10q23.2-q23.3 10q23.2-q23.3 LS cord-028721-x6f26ahr 4413 1 Enfermedad Enfermedad NNP cord-028721-x6f26ahr 4413 2 de de NNP cord-028721-x6f26ahr 4413 3 Wolman Wolman NNP cord-028721-x6f26ahr 4413 4 . . . cord-028721-x6f26ahr 4414 1 Estudio Estudio NNP cord-028721-x6f26ahr 4414 2 anatomopatológico anatomopatológico NNP cord-028721-x6f26ahr 4414 3 de de NNP cord-028721-x6f26ahr 4414 4 dos dos NNP cord-028721-x6f26ahr 4414 5 observaciones observaciones NNP cord-028721-x6f26ahr 4415 1 Autopsy autopsy JJ cord-028721-x6f26ahr 4415 2 report report NN cord-028721-x6f26ahr 4415 3 of of IN cord-028721-x6f26ahr 4415 4 an an DT cord-028721-x6f26ahr 4415 5 adult adult NN cord-028721-x6f26ahr 4415 6 case case NN cord-028721-x6f26ahr 4415 7 with with IN cord-028721-x6f26ahr 4415 8 a a DT cord-028721-x6f26ahr 4415 9 long long RB cord-028721-x6f26ahr 4415 10 - - HYPH cord-028721-x6f26ahr 4415 11 standing stand VBG cord-028721-x6f26ahr 4415 12 subclinical subclinical JJ cord-028721-x6f26ahr 4415 13 course course NN cord-028721-x6f26ahr 4415 14 complicated complicate VBN cord-028721-x6f26ahr 4415 15 by by IN cord-028721-x6f26ahr 4415 16 accelerated accelerated JJ cord-028721-x6f26ahr 4415 17 atherosclerosis atherosclerosis NN cord-028721-x6f26ahr 4415 18 and and CC cord-028721-x6f26ahr 4415 19 liver liver NN cord-028721-x6f26ahr 4415 20 carcinoma carcinoma NN cord-028721-x6f26ahr 4415 21 Successful successful JJ cord-028721-x6f26ahr 4415 22 treatment treatment NN cord-028721-x6f26ahr 4415 23 of of IN cord-028721-x6f26ahr 4415 24 Wolman Wolman NNP cord-028721-x6f26ahr 4415 25 disease disease NN cord-028721-x6f26ahr 4415 26 by by IN cord-028721-x6f26ahr 4415 27 unrelated unrelated JJ cord-028721-x6f26ahr 4415 28 umbilical umbilical JJ cord-028721-x6f26ahr 4415 29 cord cord NN cord-028721-x6f26ahr 4415 30 blood blood NN cord-028721-x6f26ahr 4415 31 transplantation transplantation NN cord-028721-x6f26ahr 4415 32 Pituitary Pituitary NNP cord-028721-x6f26ahr 4415 33 - - HYPH cord-028721-x6f26ahr 4415 34 testicular testicular NN cord-028721-x6f26ahr 4415 35 function function NN cord-028721-x6f26ahr 4415 36 in in IN cord-028721-x6f26ahr 4415 37 nephropathic nephropathic NNP cord-028721-x6f26ahr 4415 38 cystinosis cystinosis NNP cord-028721-x6f26ahr 4416 1 Lysosomal Lysosomal NNP cord-028721-x6f26ahr 4416 2 diseases disease NNS cord-028721-x6f26ahr 4416 3 Environmental environmental JJ cord-028721-x6f26ahr 4416 4 infl infl NN cord-028721-x6f26ahr 4416 5 uences uence NNS cord-028721-x6f26ahr 4416 6 on on IN cord-028721-x6f26ahr 4416 7 male male JJ cord-028721-x6f26ahr 4416 8 reproductive reproductive JJ cord-028721-x6f26ahr 4416 9 health health NN cord-028721-x6f26ahr 4416 10 Occupational Occupational NNP cord-028721-x6f26ahr 4416 11 exposures exposure NNS cord-028721-x6f26ahr 4416 12 associated associate VBN cord-028721-x6f26ahr 4416 13 with with IN cord-028721-x6f26ahr 4416 14 male male JJ cord-028721-x6f26ahr 4416 15 reproductive reproductive JJ cord-028721-x6f26ahr 4416 16 dysfunction dysfunction NN cord-028721-x6f26ahr 4416 17 Semen Semen NNP cord-028721-x6f26ahr 4416 18 quality quality NN cord-028721-x6f26ahr 4416 19 in in IN cord-028721-x6f26ahr 4416 20 fertile fertile JJ cord-028721-x6f26ahr 4416 21 US US NNP cord-028721-x6f26ahr 4416 22 men man NNS cord-028721-x6f26ahr 4416 23 in in IN cord-028721-x6f26ahr 4416 24 relation relation NN cord-028721-x6f26ahr 4416 25 to to IN cord-028721-x6f26ahr 4416 26 geographical geographical JJ cord-028721-x6f26ahr 4416 27 area area NN cord-028721-x6f26ahr 4416 28 and and CC cord-028721-x6f26ahr 4416 29 pesticide pesticide NN cord-028721-x6f26ahr 4416 30 exposure exposure NN cord-028721-x6f26ahr 4417 1 Semen semen NN cord-028721-x6f26ahr 4417 2 quality quality NN cord-028721-x6f26ahr 4417 3 of of IN cord-028721-x6f26ahr 4417 4 workers worker NNS cord-028721-x6f26ahr 4417 5 occupationally occupationally RB cord-028721-x6f26ahr 4417 6 exposed expose VBN cord-028721-x6f26ahr 4417 7 to to IN cord-028721-x6f26ahr 4417 8 hydrocarbons hydrocarbon NNS cord-028721-x6f26ahr 4417 9 Semen semen NN cord-028721-x6f26ahr 4417 10 quality quality NN cord-028721-x6f26ahr 4417 11 in in IN cord-028721-x6f26ahr 4417 12 workers worker NNS cord-028721-x6f26ahr 4417 13 exposed expose VBN cord-028721-x6f26ahr 4417 14 to to IN cord-028721-x6f26ahr 4417 15 carbon carbon NN cord-028721-x6f26ahr 4417 16 disulfi disulfi NNP cord-028721-x6f26ahr 4417 17 de de XX cord-028721-x6f26ahr 4417 18 compared compare VBN cord-028721-x6f26ahr 4417 19 to to IN cord-028721-x6f26ahr 4417 20 a a DT cord-028721-x6f26ahr 4417 21 control control NN cord-028721-x6f26ahr 4417 22 group group NN cord-028721-x6f26ahr 4417 23 from from IN cord-028721-x6f26ahr 4417 24 the the DT cord-028721-x6f26ahr 4417 25 same same JJ cord-028721-x6f26ahr 4417 26 plant plant NN cord-028721-x6f26ahr 4418 1 Endocrinologic Endocrinologic NNP cord-028721-x6f26ahr 4418 2 studies study NNS cord-028721-x6f26ahr 4418 3 in in IN cord-028721-x6f26ahr 4418 4 men man NNS cord-028721-x6f26ahr 4418 5 exposed expose VBD cord-028721-x6f26ahr 4418 6 occupationally occupationally RB cord-028721-x6f26ahr 4418 7 to to IN cord-028721-x6f26ahr 4418 8 carbon carbon VB cord-028721-x6f26ahr 4418 9 disulfi disulfi NNP cord-028721-x6f26ahr 4418 10 de de NNP cord-028721-x6f26ahr 4418 11 Y Y NNP cord-028721-x6f26ahr 4418 12 - - HYPH cord-028721-x6f26ahr 4418 13 chromosomal chromosomal JJ cord-028721-x6f26ahr 4418 14 nondysjunction nondysjunction NN cord-028721-x6f26ahr 4418 15 in in IN cord-028721-x6f26ahr 4418 16 dibromochloropropane dibromochloropropane NNP cord-028721-x6f26ahr 4418 17 exposed expose VBD cord-028721-x6f26ahr 4418 18 workmen workman NNS cord-028721-x6f26ahr 4419 1 Inorganic inorganic JJ cord-028721-x6f26ahr 4419 2 lead lead VBP cord-028721-x6f26ahr 4419 3 exposure exposure NN cord-028721-x6f26ahr 4419 4 in in IN cord-028721-x6f26ahr 4419 5 battery battery NN cord-028721-x6f26ahr 4419 6 and and CC cord-028721-x6f26ahr 4419 7 paint paint NN cord-028721-x6f26ahr 4419 8 factory factory NN cord-028721-x6f26ahr 4419 9 : : : cord-028721-x6f26ahr 4419 10 effect effect NN cord-028721-x6f26ahr 4419 11 on on IN cord-028721-x6f26ahr 4419 12 human human JJ cord-028721-x6f26ahr 4419 13 sperm sperm NN cord-028721-x6f26ahr 4419 14 structure structure NN cord-028721-x6f26ahr 4419 15 and and CC cord-028721-x6f26ahr 4419 16 functional functional JJ cord-028721-x6f26ahr 4419 17 activity activity NN cord-028721-x6f26ahr 4419 18 Reproductive reproductive JJ cord-028721-x6f26ahr 4419 19 ability ability NN cord-028721-x6f26ahr 4419 20 of of IN cord-028721-x6f26ahr 4419 21 workmen workman NNS cord-028721-x6f26ahr 4419 22 occupationally occupationally RB cord-028721-x6f26ahr 4419 23 exposed expose VBN cord-028721-x6f26ahr 4419 24 to to TO cord-028721-x6f26ahr 4419 25 lead lead VB cord-028721-x6f26ahr 4419 26 Endocrine endocrine JJ cord-028721-x6f26ahr 4419 27 and and CC cord-028721-x6f26ahr 4419 28 reproductive reproductive JJ cord-028721-x6f26ahr 4419 29 dysfunction dysfunction NN cord-028721-x6f26ahr 4419 30 in in IN cord-028721-x6f26ahr 4419 31 men man NNS cord-028721-x6f26ahr 4419 32 associated associate VBN cord-028721-x6f26ahr 4419 33 with with IN cord-028721-x6f26ahr 4419 34 occupational occupational JJ cord-028721-x6f26ahr 4419 35 inorganic inorganic JJ cord-028721-x6f26ahr 4419 36 lead lead NN cord-028721-x6f26ahr 4419 37 intoxication intoxication NN cord-028721-x6f26ahr 4419 38 Occupational occupational JJ cord-028721-x6f26ahr 4419 39 exposure exposure NN cord-028721-x6f26ahr 4419 40 to to IN cord-028721-x6f26ahr 4419 41 synthetic synthetic JJ cord-028721-x6f26ahr 4419 42 estrogens estrogen NNS cord-028721-x6f26ahr 4419 43 : : : cord-028721-x6f26ahr 4420 1 some some DT cord-028721-x6f26ahr 4420 2 methodological methodological JJ cord-028721-x6f26ahr 4420 3 problems problems NNPS cord-028721-x6f26ahr 4420 4 Association Association NNP cord-028721-x6f26ahr 4420 5 of of IN cord-028721-x6f26ahr 4420 6 diethylstilbestrol diethylstilbestrol NNP cord-028721-x6f26ahr 4420 7 exposure exposure NN cord-028721-x6f26ahr 4420 8 in in IN cord-028721-x6f26ahr 4420 9 utero utero NN cord-028721-x6f26ahr 4420 10 with with IN cord-028721-x6f26ahr 4420 11 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4420 12 , , , cord-028721-x6f26ahr 4420 13 testicular testicular JJ cord-028721-x6f26ahr 4420 14 hypoplasia hypoplasia NN cord-028721-x6f26ahr 4420 15 and and CC cord-028721-x6f26ahr 4420 16 semen semen NN cord-028721-x6f26ahr 4420 17 abnormalities abnormality NNS cord-028721-x6f26ahr 4421 1 Altered alter VBN cord-028721-x6f26ahr 4421 2 semen semen NN cord-028721-x6f26ahr 4421 3 quality quality NN cord-028721-x6f26ahr 4421 4 in in IN cord-028721-x6f26ahr 4421 5 relation relation NN cord-028721-x6f26ahr 4421 6 to to IN cord-028721-x6f26ahr 4421 7 urinary urinary JJ cord-028721-x6f26ahr 4421 8 concentrations concentration NNS cord-028721-x6f26ahr 4421 9 of of IN cord-028721-x6f26ahr 4421 10 phthalate phthalate NN cord-028721-x6f26ahr 4421 11 monoester monoester NN cord-028721-x6f26ahr 4421 12 and and CC cord-028721-x6f26ahr 4421 13 oxidative oxidative JJ cord-028721-x6f26ahr 4421 14 metabolites metabolite NNS cord-028721-x6f26ahr 4421 15 Current current JJ cord-028721-x6f26ahr 4421 16 use use NN cord-028721-x6f26ahr 4421 17 of of IN cord-028721-x6f26ahr 4421 18 pesticides pesticide NNS cord-028721-x6f26ahr 4421 19 in in IN cord-028721-x6f26ahr 4421 20 Poland Poland NNP cord-028721-x6f26ahr 4421 21 and and CC cord-028721-x6f26ahr 4421 22 the the DT cord-028721-x6f26ahr 4421 23 risk risk NN cord-028721-x6f26ahr 4421 24 of of IN cord-028721-x6f26ahr 4421 25 reproductive reproductive JJ cord-028721-x6f26ahr 4421 26 disorders disorder NNS cord-028721-x6f26ahr 4422 1 The the DT cord-028721-x6f26ahr 4422 2 environment environment NN cord-028721-x6f26ahr 4422 3 and and CC cord-028721-x6f26ahr 4422 4 male male JJ cord-028721-x6f26ahr 4422 5 fertility fertility NN cord-028721-x6f26ahr 4422 6 : : : cord-028721-x6f26ahr 4422 7 recent recent JJ cord-028721-x6f26ahr 4422 8 research research NN cord-028721-x6f26ahr 4422 9 on on IN cord-028721-x6f26ahr 4422 10 emerging emerge VBG cord-028721-x6f26ahr 4422 11 chemicals chemical NNS cord-028721-x6f26ahr 4422 12 and and CC cord-028721-x6f26ahr 4422 13 semen semen NN cord-028721-x6f26ahr 4422 14 quality quality NN cord-028721-x6f26ahr 4422 15 Exposure exposure NN cord-028721-x6f26ahr 4422 16 to to IN cord-028721-x6f26ahr 4422 17 exogenous exogenous JJ cord-028721-x6f26ahr 4422 18 estrogens estrogen NNS cord-028721-x6f26ahr 4422 19 in in IN cord-028721-x6f26ahr 4422 20 food food NN cord-028721-x6f26ahr 4422 21 : : : cord-028721-x6f26ahr 4422 22 possible possible JJ cord-028721-x6f26ahr 4422 23 impact impact NN cord-028721-x6f26ahr 4422 24 on on IN cord-028721-x6f26ahr 4422 25 human human JJ cord-028721-x6f26ahr 4422 26 development development NN cord-028721-x6f26ahr 4422 27 and and CC cord-028721-x6f26ahr 4422 28 health health NNP cord-028721-x6f26ahr 4422 29 Testicular Testicular NNP cord-028721-x6f26ahr 4422 30 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4422 31 syndrome syndrome NN cord-028721-x6f26ahr 4422 32 ; ; : cord-028721-x6f26ahr 4422 33 an an DT cord-028721-x6f26ahr 4422 34 increasingly increasingly RB cord-028721-x6f26ahr 4422 35 common common JJ cord-028721-x6f26ahr 4422 36 developmental developmental JJ cord-028721-x6f26ahr 4422 37 disorder disorder NN cord-028721-x6f26ahr 4422 38 with with IN cord-028721-x6f26ahr 4422 39 environmental environmental JJ cord-028721-x6f26ahr 4422 40 aspects aspect NNS cord-028721-x6f26ahr 4422 41 Environmental environmental JJ cord-028721-x6f26ahr 4422 42 infl infl NN cord-028721-x6f26ahr 4422 43 uences uence NNS cord-028721-x6f26ahr 4422 44 on on IN cord-028721-x6f26ahr 4422 45 male male JJ cord-028721-x6f26ahr 4422 46 reproduction reproduction NN cord-028721-x6f26ahr 4422 47 Effects effect NNS cord-028721-x6f26ahr 4422 48 of of IN cord-028721-x6f26ahr 4422 49 delta-9-tetrahydrocannabinol delta-9-tetrahydrocannabinol NNP cord-028721-x6f26ahr 4422 50 , , , cord-028721-x6f26ahr 4422 51 the the DT cord-028721-x6f26ahr 4422 52 primary primary JJ cord-028721-x6f26ahr 4422 53 psychoactive psychoactive JJ cord-028721-x6f26ahr 4422 54 cannabinoid cannabinoid NN cord-028721-x6f26ahr 4422 55 in in IN cord-028721-x6f26ahr 4422 56 marijuana marijuana NN cord-028721-x6f26ahr 4422 57 , , , cord-028721-x6f26ahr 4422 58 on on IN cord-028721-x6f26ahr 4422 59 human human JJ cord-028721-x6f26ahr 4422 60 sperm sperm NN cord-028721-x6f26ahr 4422 61 function function NN cord-028721-x6f26ahr 4422 62 in in IN cord-028721-x6f26ahr 4422 63 vitro vitro FW cord-028721-x6f26ahr 4422 64 Effect effect NN cord-028721-x6f26ahr 4422 65 of of IN cord-028721-x6f26ahr 4422 66 cocaine cocaine NN cord-028721-x6f26ahr 4422 67 on on IN cord-028721-x6f26ahr 4422 68 germ germ NN cord-028721-x6f26ahr 4422 69 cell cell NN cord-028721-x6f26ahr 4422 70 apoptosis apoptosis NN cord-028721-x6f26ahr 4422 71 in in IN cord-028721-x6f26ahr 4422 72 rats rat NNS cord-028721-x6f26ahr 4422 73 at at IN cord-028721-x6f26ahr 4422 74 different different JJ cord-028721-x6f26ahr 4422 75 ages age NNS cord-028721-x6f26ahr 4422 76 Effect effect NN cord-028721-x6f26ahr 4422 77 of of IN cord-028721-x6f26ahr 4422 78 chronic chronic JJ cord-028721-x6f26ahr 4422 79 alcoholism alcoholism NN cord-028721-x6f26ahr 4422 80 on on IN cord-028721-x6f26ahr 4422 81 male male JJ cord-028721-x6f26ahr 4422 82 fertility fertility NN cord-028721-x6f26ahr 4422 83 hormones hormone NNS cord-028721-x6f26ahr 4422 84 and and CC cord-028721-x6f26ahr 4422 85 semen semen NN cord-028721-x6f26ahr 4422 86 quality quality NN cord-028721-x6f26ahr 4422 87 Effect effect NN cord-028721-x6f26ahr 4422 88 of of IN cord-028721-x6f26ahr 4422 89 smoking smoking NN cord-028721-x6f26ahr 4422 90 on on IN cord-028721-x6f26ahr 4422 91 semen semen NN cord-028721-x6f26ahr 4422 92 parameters parameter NNS cord-028721-x6f26ahr 4422 93 of of IN cord-028721-x6f26ahr 4422 94 men man NNS cord-028721-x6f26ahr 4422 95 attending attend VBG cord-028721-x6f26ahr 4422 96 an an DT cord-028721-x6f26ahr 4422 97 infertility infertility NN cord-028721-x6f26ahr 4422 98 clinic clinic NN cord-028721-x6f26ahr 4422 99 Concomitant concomitant JJ cord-028721-x6f26ahr 4422 100 abuse abuse NN cord-028721-x6f26ahr 4422 101 of of IN cord-028721-x6f26ahr 4422 102 anabolic anabolic JJ cord-028721-x6f26ahr 4422 103 androgenic androgenic JJ cord-028721-x6f26ahr 4422 104 steroids steroid NNS cord-028721-x6f26ahr 4422 105 and and CC cord-028721-x6f26ahr 4422 106 human human JJ cord-028721-x6f26ahr 4422 107 chorionic chorionic JJ cord-028721-x6f26ahr 4422 108 gonadotrophin gonadotrophin NN cord-028721-x6f26ahr 4422 109 impairs impair VBZ cord-028721-x6f26ahr 4422 110 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4422 111 in in IN cord-028721-x6f26ahr 4422 112 power power NN cord-028721-x6f26ahr 4422 113 athletes athlete NNS cord-028721-x6f26ahr 4423 1 The the DT cord-028721-x6f26ahr 4423 2 infl infl NN cord-028721-x6f26ahr 4423 3 uence uence NN cord-028721-x6f26ahr 4423 4 of of IN cord-028721-x6f26ahr 4423 5 radiation radiation NN cord-028721-x6f26ahr 4423 6 on on IN cord-028721-x6f26ahr 4423 7 fertility fertility NN cord-028721-x6f26ahr 4423 8 in in IN cord-028721-x6f26ahr 4423 9 man man NN cord-028721-x6f26ahr 4423 10 Gonadal Gonadal NNP cord-028721-x6f26ahr 4423 11 function function NN cord-028721-x6f26ahr 4423 12 in in IN cord-028721-x6f26ahr 4423 13 workmen workman NNS cord-028721-x6f26ahr 4423 14 with with IN cord-028721-x6f26ahr 4423 15 long long JJ cord-028721-x6f26ahr 4423 16 term term NN cord-028721-x6f26ahr 4423 17 exposure exposure NN cord-028721-x6f26ahr 4423 18 to to IN cord-028721-x6f26ahr 4423 19 microwaves microwave NNS cord-028721-x6f26ahr 4423 20 Effects effect NNS cord-028721-x6f26ahr 4423 21 of of IN cord-028721-x6f26ahr 4423 22 artifi artifi NN cord-028721-x6f26ahr 4423 23 cial cial JJ cord-028721-x6f26ahr 4423 24 cryptorchidism cryptorchidism NN cord-028721-x6f26ahr 4423 25 on on IN cord-028721-x6f26ahr 4423 26 sperm sperm NN cord-028721-x6f26ahr 4423 27 morphology morphology NN cord-028721-x6f26ahr 4423 28 Spermatogenic Spermatogenic NNP cord-028721-x6f26ahr 4423 29 arrest arrest NN cord-028721-x6f26ahr 4423 30 in in IN cord-028721-x6f26ahr 4423 31 men man NNS cord-028721-x6f26ahr 4423 32 with with IN cord-028721-x6f26ahr 4423 33 testicular testicular JJ cord-028721-x6f26ahr 4423 34 hyperthermia hyperthermia NN cord-028721-x6f26ahr 4424 1 The the DT cord-028721-x6f26ahr 4424 2 effect effect NN cord-028721-x6f26ahr 4424 3 of of IN cord-028721-x6f26ahr 4424 4 hyperthermia hyperthermia NN cord-028721-x6f26ahr 4424 5 on on IN cord-028721-x6f26ahr 4424 6 ornithine ornithine NN cord-028721-x6f26ahr 4424 7 decarboxylase decarboxylase NN cord-028721-x6f26ahr 4424 8 activity activity NN cord-028721-x6f26ahr 4424 9 in in IN cord-028721-x6f26ahr 4424 10 different different JJ cord-028721-x6f26ahr 4424 11 rat rat NN cord-028721-x6f26ahr 4424 12 tissue tissue NN cord-028721-x6f26ahr 4424 13 Effects effect NNS cord-028721-x6f26ahr 4424 14 of of IN cord-028721-x6f26ahr 4424 15 L l NN cord-028721-x6f26ahr 4424 16 - - HYPH cord-028721-x6f26ahr 4424 17 acetylcarnitine acetylcarnitine NNP cord-028721-x6f26ahr 4424 18 ( ( -LRB- cord-028721-x6f26ahr 4424 19 LAC LAC NNP cord-028721-x6f26ahr 4424 20 ) ) -RRB- cord-028721-x6f26ahr 4424 21 on on IN cord-028721-x6f26ahr 4424 22 the the DT cord-028721-x6f26ahr 4424 23 post post JJ cord-028721-x6f26ahr 4424 24 - - JJ cord-028721-x6f26ahr 4424 25 injury injury JJ cord-028721-x6f26ahr 4424 26 recovery recovery NN cord-028721-x6f26ahr 4424 27 of of IN cord-028721-x6f26ahr 4424 28 mouse mouse NN cord-028721-x6f26ahr 4424 29 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4424 30 monitored monitor VBN cord-028721-x6f26ahr 4424 31 by by IN cord-028721-x6f26ahr 4424 32 fl fl NNP cord-028721-x6f26ahr 4424 33 ow ow NN cord-028721-x6f26ahr 4424 34 cytometry cytometry NN cord-028721-x6f26ahr 4424 35 . . . cord-028721-x6f26ahr 4425 1 Recovery recovery NN cord-028721-x6f26ahr 4425 2 after after IN cord-028721-x6f26ahr 4425 3 hyperthermic hyperthermic JJ cord-028721-x6f26ahr 4425 4 treatment treatment NN cord-028721-x6f26ahr 4426 1 The the DT cord-028721-x6f26ahr 4426 2 role role NN cord-028721-x6f26ahr 4426 3 of of IN cord-028721-x6f26ahr 4426 4 carnitine carnitine NN cord-028721-x6f26ahr 4426 5 in in IN cord-028721-x6f26ahr 4426 6 spermatozoa spermatozoa JJ cord-028721-x6f26ahr 4426 7 metabolism metabolism NN cord-028721-x6f26ahr 4426 8 . . . cord-028721-x6f26ahr 4427 1 Substrate substrate NN cord-028721-x6f26ahr 4427 2 induced induce VBN cord-028721-x6f26ahr 4427 3 elevations elevation NNS cord-028721-x6f26ahr 4427 4 in in IN cord-028721-x6f26ahr 4427 5 the the DT cord-028721-x6f26ahr 4427 6 acetylation acetylation NN cord-028721-x6f26ahr 4427 7 state state NN cord-028721-x6f26ahr 4427 8 of of IN cord-028721-x6f26ahr 4427 9 carnitine carnitine NN cord-028721-x6f26ahr 4427 10 and and CC cord-028721-x6f26ahr 4427 11 coenzyme coenzyme VBZ cord-028721-x6f26ahr 4427 12 A a NN cord-028721-x6f26ahr 4427 13 in in IN cord-028721-x6f26ahr 4427 14 bovine bovine NN cord-028721-x6f26ahr 4427 15 and and CC cord-028721-x6f26ahr 4427 16 monkey monkey NN cord-028721-x6f26ahr 4427 17 spermatozoa spermatozoon NNS cord-028721-x6f26ahr 4428 1 In in IN cord-028721-x6f26ahr 4428 2 vitro vitro FW cord-028721-x6f26ahr 4428 3 temperature temperature NN cord-028721-x6f26ahr 4428 4 sensitivity sensitivity NN cord-028721-x6f26ahr 4428 5 of of IN cord-028721-x6f26ahr 4428 6 DNA DNA NNP cord-028721-x6f26ahr 4428 7 , , , cord-028721-x6f26ahr 4428 8 RNA RNA NNP cord-028721-x6f26ahr 4428 9 , , , cord-028721-x6f26ahr 4428 10 and and CC cord-028721-x6f26ahr 4428 11 protein protein NN cord-028721-x6f26ahr 4428 12 synthesis synthesis NN cord-028721-x6f26ahr 4428 13 throughout throughout IN cord-028721-x6f26ahr 4428 14 puberty puberty NN cord-028721-x6f26ahr 4428 15 in in IN cord-028721-x6f26ahr 4428 16 human human JJ cord-028721-x6f26ahr 4428 17 testis testis NN cord-028721-x6f26ahr 4428 18 Traumatic traumatic JJ cord-028721-x6f26ahr 4428 19 dislocation dislocation NN cord-028721-x6f26ahr 4428 20 of of IN cord-028721-x6f26ahr 4428 21 testes testis NNS cord-028721-x6f26ahr 4428 22 and and CC cord-028721-x6f26ahr 4428 23 bladder bladder NN cord-028721-x6f26ahr 4428 24 rupture rupture NN cord-028721-x6f26ahr 4428 25 Report Report NNP cord-028721-x6f26ahr 4428 26 of of IN cord-028721-x6f26ahr 4428 27 2 2 CD cord-028721-x6f26ahr 4428 28 new new JJ cord-028721-x6f26ahr 4428 29 cases case NNS cord-028721-x6f26ahr 4428 30 and and CC cord-028721-x6f26ahr 4428 31 review review NN cord-028721-x6f26ahr 4428 32 of of IN cord-028721-x6f26ahr 4428 33 the the DT cord-028721-x6f26ahr 4428 34 literature literature NN cord-028721-x6f26ahr 4429 1 Traumatic traumatic JJ cord-028721-x6f26ahr 4429 2 dislocation dislocation NN cord-028721-x6f26ahr 4429 3 of of IN cord-028721-x6f26ahr 4429 4 testis testis NN cord-028721-x6f26ahr 4429 5 Traumatic traumatic JJ cord-028721-x6f26ahr 4429 6 testicular testicular JJ cord-028721-x6f26ahr 4429 7 dislocation dislocation NN cord-028721-x6f26ahr 4429 8 a a DT cord-028721-x6f26ahr 4429 9 review review NN cord-028721-x6f26ahr 4429 10 of of IN cord-028721-x6f26ahr 4429 11 36 36 CD cord-028721-x6f26ahr 4429 12 cases case NNS cord-028721-x6f26ahr 4429 13 Restoration restoration NN cord-028721-x6f26ahr 4429 14 of of IN cord-028721-x6f26ahr 4429 15 spermatogenesis spermatogenesis NN cord-028721-x6f26ahr 4429 16 by by IN cord-028721-x6f26ahr 4429 17 orchiopexy orchiopexy NNP cord-028721-x6f26ahr 4429 18 13 13 CD cord-028721-x6f26ahr 4429 19 years year NNS cord-028721-x6f26ahr 4429 20 after after IN cord-028721-x6f26ahr 4429 21 bilateral bilateral JJ cord-028721-x6f26ahr 4429 22 traumatic traumatic JJ cord-028721-x6f26ahr 4429 23 testicular testicular JJ cord-028721-x6f26ahr 4429 24 dislocation dislocation NN cord-028721-x6f26ahr 4429 25 Sexuality sexuality NN cord-028721-x6f26ahr 4429 26 and and CC cord-028721-x6f26ahr 4429 27 fertility fertility NN cord-028721-x6f26ahr 4429 28 in in IN cord-028721-x6f26ahr 4429 29 long long JJ cord-028721-x6f26ahr 4429 30 - - HYPH cord-028721-x6f26ahr 4429 31 term term NN cord-028721-x6f26ahr 4429 32 survivors survivor NNS cord-028721-x6f26ahr 4429 33 of of IN cord-028721-x6f26ahr 4429 34 testicular testicular JJ cord-028721-x6f26ahr 4429 35 cancer cancer NN cord-028721-x6f26ahr 4429 36 Fertility fertility NN cord-028721-x6f26ahr 4429 37 and and CC cord-028721-x6f26ahr 4429 38 pregnancy pregnancy NN cord-028721-x6f26ahr 4429 39 after after IN cord-028721-x6f26ahr 4429 40 treatment treatment NN cord-028721-x6f26ahr 4429 41 for for IN cord-028721-x6f26ahr 4429 42 cancer cancer NN cord-028721-x6f26ahr 4429 43 during during IN cord-028721-x6f26ahr 4429 44 childhood childhood NN cord-028721-x6f26ahr 4429 45 or or CC cord-028721-x6f26ahr 4429 46 adolescence adolescence NN cord-028721-x6f26ahr 4429 47 Male male JJ cord-028721-x6f26ahr 4429 48 gonadal gonadal NN cord-028721-x6f26ahr 4429 49 dose dose NN cord-028721-x6f26ahr 4429 50 in in IN cord-028721-x6f26ahr 4429 51 adjuvant adjuvant JJ cord-028721-x6f26ahr 4429 52 3-d 3-d JJ cord-028721-x6f26ahr 4429 53 - - HYPH cord-028721-x6f26ahr 4429 54 pelvic pelvic NN cord-028721-x6f26ahr 4429 55 irradiation irradiation NN cord-028721-x6f26ahr 4429 56 after after IN cord-028721-x6f26ahr 4429 57 anterior anterior JJ cord-028721-x6f26ahr 4429 58 resection resection NN cord-028721-x6f26ahr 4429 59 of of IN cord-028721-x6f26ahr 4429 60 rectal rectal JJ cord-028721-x6f26ahr 4429 61 cancer cancer NN cord-028721-x6f26ahr 4429 62 . . . cord-028721-x6f26ahr 4430 1 Infl infl NN cord-028721-x6f26ahr 4430 2 uence uence NN cord-028721-x6f26ahr 4430 3 to to IN cord-028721-x6f26ahr 4430 4 fertility fertility NN cord-028721-x6f26ahr 4430 5 Recovery Recovery NNP cord-028721-x6f26ahr 4430 6 from from IN cord-028721-x6f26ahr 4430 7 aspermia aspermia NN cord-028721-x6f26ahr 4430 8 induced induce VBN cord-028721-x6f26ahr 4430 9 by by IN cord-028721-x6f26ahr 4430 10 low low JJ cord-028721-x6f26ahr 4430 11 - - HYPH cord-028721-x6f26ahr 4430 12 dose dose NN cord-028721-x6f26ahr 4430 13 radiation radiation NN cord-028721-x6f26ahr 4430 14 in in IN cord-028721-x6f26ahr 4430 15 seminoma seminoma NN cord-028721-x6f26ahr 4430 16 patients patient NNS cord-028721-x6f26ahr 4431 1 Aspermia aspermia NN cord-028721-x6f26ahr 4431 2 following follow VBG cord-028721-x6f26ahr 4431 3 lower low JJR cord-028721-x6f26ahr 4431 4 truncal truncal NN cord-028721-x6f26ahr 4431 5 irradiation irradiation NN cord-028721-x6f26ahr 4431 6 in in IN cord-028721-x6f26ahr 4431 7 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 4431 8 's 's POS cord-028721-x6f26ahr 4431 9 disease disease NN cord-028721-x6f26ahr 4431 10 Testicular Testicular NNP cord-028721-x6f26ahr 4431 11 function function NN cord-028721-x6f26ahr 4431 12 in in IN cord-028721-x6f26ahr 4431 13 eight eight CD cord-028721-x6f26ahr 4431 14 patients patient NNS cord-028721-x6f26ahr 4431 15 with with IN cord-028721-x6f26ahr 4431 16 seminoma seminoma NNS cord-028721-x6f26ahr 4431 17 after after IN cord-028721-x6f26ahr 4431 18 unilateral unilateral JJ cord-028721-x6f26ahr 4431 19 orchidectomy orchidectomy NN cord-028721-x6f26ahr 4431 20 and and CC cord-028721-x6f26ahr 4431 21 radiotherapy radiotherapy NN cord-028721-x6f26ahr 4431 22 Paternity paternity NN cord-028721-x6f26ahr 4431 23 after after IN cord-028721-x6f26ahr 4431 24 irradiation irradiation NN cord-028721-x6f26ahr 4431 25 for for IN cord-028721-x6f26ahr 4431 26 testicular testicular JJ cord-028721-x6f26ahr 4431 27 cancer cancer NN cord-028721-x6f26ahr 4431 28 Gonadal Gonadal NNP cord-028721-x6f26ahr 4431 29 function function NN cord-028721-x6f26ahr 4431 30 in in IN cord-028721-x6f26ahr 4431 31 patients patient NNS cord-028721-x6f26ahr 4431 32 with with IN cord-028721-x6f26ahr 4431 33 differentiated differentiated JJ cord-028721-x6f26ahr 4431 34 thyroid thyroid JJ cord-028721-x6f26ahr 4431 35 cancer cancer NN cord-028721-x6f26ahr 4431 36 treated treat VBN cord-028721-x6f26ahr 4431 37 with with IN cord-028721-x6f26ahr 4431 38 ( ( -LRB- cord-028721-x6f26ahr 4431 39 131)I 131)i CD cord-028721-x6f26ahr 4431 40 Effects effect NNS cord-028721-x6f26ahr 4431 41 of of IN cord-028721-x6f26ahr 4431 42 electromagnetic electromagnetic JJ cord-028721-x6f26ahr 4431 43 radiation radiation NN cord-028721-x6f26ahr 4431 44 from from IN cord-028721-x6f26ahr 4431 45 a a DT cord-028721-x6f26ahr 4431 46 cellular cellular JJ cord-028721-x6f26ahr 4431 47 phone phone NN cord-028721-x6f26ahr 4431 48 on on IN cord-028721-x6f26ahr 4431 49 human human JJ cord-028721-x6f26ahr 4431 50 sperm sperm NN cord-028721-x6f26ahr 4431 51 motility motility NN cord-028721-x6f26ahr 4431 52 : : : cord-028721-x6f26ahr 4431 53 an an DT cord-028721-x6f26ahr 4431 54 in in FW cord-028721-x6f26ahr 4431 55 vitro vitro FW cord-028721-x6f26ahr 4431 56 study study NN cord-028721-x6f26ahr 4431 57 Development Development NNP cord-028721-x6f26ahr 4431 58 of of IN cord-028721-x6f26ahr 4431 59 the the DT cord-028721-x6f26ahr 4431 60 seminiferous seminiferous JJ cord-028721-x6f26ahr 4431 61 epithelium epithelium NN cord-028721-x6f26ahr 4431 62 during during IN cord-028721-x6f26ahr 4431 63 and and CC cord-028721-x6f26ahr 4431 64 after after IN cord-028721-x6f26ahr 4431 65 treatment treatment NN cord-028721-x6f26ahr 4431 66 for for IN cord-028721-x6f26ahr 4431 67 acute acute JJ cord-028721-x6f26ahr 4431 68 lymphoblastic lymphoblastic JJ cord-028721-x6f26ahr 4431 69 leukemia leukemia NN cord-028721-x6f26ahr 4431 70 in in IN cord-028721-x6f26ahr 4431 71 childhood childhood NN cord-028721-x6f26ahr 4431 72 Gonadal Gonadal NNP cord-028721-x6f26ahr 4431 73 effects effect NNS cord-028721-x6f26ahr 4431 74 of of IN cord-028721-x6f26ahr 4431 75 cancer cancer NN cord-028721-x6f26ahr 4431 76 therapy therapy NN cord-028721-x6f26ahr 4431 77 in in IN cord-028721-x6f26ahr 4431 78 boys boy NNS cord-028721-x6f26ahr 4432 1 The the DT cord-028721-x6f26ahr 4432 2 effects effect NNS cord-028721-x6f26ahr 4432 3 of of IN cord-028721-x6f26ahr 4432 4 different different JJ cord-028721-x6f26ahr 4432 5 cumulative cumulative JJ cord-028721-x6f26ahr 4432 6 doses dose NNS cord-028721-x6f26ahr 4432 7 of of IN cord-028721-x6f26ahr 4432 8 chemotherapy chemotherapy NN cord-028721-x6f26ahr 4432 9 on on IN cord-028721-x6f26ahr 4432 10 testicular testicular JJ cord-028721-x6f26ahr 4432 11 function function NN cord-028721-x6f26ahr 4432 12 Impact Impact NNP cord-028721-x6f26ahr 4432 13 of of IN cord-028721-x6f26ahr 4432 14 cyclophosphamide cyclophosphamide NN cord-028721-x6f26ahr 4432 15 on on IN cord-028721-x6f26ahr 4432 16 long long JJ cord-028721-x6f26ahr 4432 17 - - HYPH cord-028721-x6f26ahr 4432 18 term term NN cord-028721-x6f26ahr 4432 19 reduction reduction NN cord-028721-x6f26ahr 4432 20 in in IN cord-028721-x6f26ahr 4432 21 sperm sperm NN cord-028721-x6f26ahr 4432 22 count count NN cord-028721-x6f26ahr 4432 23 in in IN cord-028721-x6f26ahr 4432 24 men man NNS cord-028721-x6f26ahr 4432 25 treated treat VBN cord-028721-x6f26ahr 4432 26 with with IN cord-028721-x6f26ahr 4432 27 combination combination NN cord-028721-x6f26ahr 4432 28 chemotherapy chemotherapy NN cord-028721-x6f26ahr 4432 29 for for IN cord-028721-x6f26ahr 4432 30 Ewing Ewing NNP cord-028721-x6f26ahr 4432 31 and and CC cord-028721-x6f26ahr 4432 32 soft soft JJ cord-028721-x6f26ahr 4432 33 tissue tissue NN cord-028721-x6f26ahr 4433 1 sarcomas sarcoma NNS cord-028721-x6f26ahr 4434 1 Sertoli sertoli JJ cord-028721-x6f26ahr 4434 2 cell cell NN cord-028721-x6f26ahr 4434 3 inactivation inactivation NN cord-028721-x6f26ahr 4434 4 by by IN cord-028721-x6f26ahr 4434 5 cytotoxic cytotoxic JJ cord-028721-x6f26ahr 4434 6 damage damage NN cord-028721-x6f26ahr 4434 7 to to IN cord-028721-x6f26ahr 4434 8 the the DT cord-028721-x6f26ahr 4434 9 human human JJ cord-028721-x6f26ahr 4434 10 testis testis NN cord-028721-x6f26ahr 4434 11 after after IN cord-028721-x6f26ahr 4434 12 cancer cancer NN cord-028721-x6f26ahr 4434 13 chemotherapy chemotherapy NN cord-028721-x6f26ahr 4434 14 Leydig Leydig NNP cord-028721-x6f26ahr 4434 15 cell cell NN cord-028721-x6f26ahr 4434 16 dysfunction dysfunction NN cord-028721-x6f26ahr 4434 17 and and CC cord-028721-x6f26ahr 4434 18 gynaecomastia gynaecomastia NN cord-028721-x6f26ahr 4434 19 in in IN cord-028721-x6f26ahr 4434 20 adult adult NN cord-028721-x6f26ahr 4434 21 males male NNS cord-028721-x6f26ahr 4434 22 treated treat VBN cord-028721-x6f26ahr 4434 23 with with IN cord-028721-x6f26ahr 4434 24 alkylating alkylating JJ cord-028721-x6f26ahr 4434 25 agents agent NNS cord-028721-x6f26ahr 4435 1 Testicular testicular NN cord-028721-x6f26ahr 4435 2 and and CC cord-028721-x6f26ahr 4435 3 sperm sperm NN cord-028721-x6f26ahr 4435 4 DNA dna NN cord-028721-x6f26ahr 4435 5 damage damage NN cord-028721-x6f26ahr 4435 6 after after IN cord-028721-x6f26ahr 4435 7 treatment treatment NN cord-028721-x6f26ahr 4435 8 with with IN cord-028721-x6f26ahr 4435 9 fl fl NNP cord-028721-x6f26ahr 4435 10 udarabine udarabine NN cord-028721-x6f26ahr 4435 11 for for IN cord-028721-x6f26ahr 4435 12 chronic chronic JJ cord-028721-x6f26ahr 4435 13 lymphocytic lymphocytic JJ cord-028721-x6f26ahr 4435 14 leukaemia leukaemia NN cord-028721-x6f26ahr 4435 15 1473 1473 CD cord-028721-x6f26ahr 4435 16 . . . cord-028721-x6f26ahr 4436 1 van van NNP cord-028721-x6f26ahr 4436 2 den den NNP cord-028721-x6f26ahr 4436 3 Berg Berg NNP cord-028721-x6f26ahr 4436 4 H H NNP cord-028721-x6f26ahr 4436 5 , , , cord-028721-x6f26ahr 4436 6 Furstner Furstner NNP cord-028721-x6f26ahr 4436 7 F F NNP cord-028721-x6f26ahr 4436 8 , , , cord-028721-x6f26ahr 4436 9 van van NNP cord-028721-x6f26ahr 4436 10 den den NNP cord-028721-x6f26ahr 4436 11 Bos Bos NNP cord-028721-x6f26ahr 4436 12 C C NNP cord-028721-x6f26ahr 4436 13 , , , cord-028721-x6f26ahr 4436 14 Behrendt Behrendt NNP cord-028721-x6f26ahr 4436 15 H. H. NNP cord-028721-x6f26ahr 4436 16 Decreasing decrease VBG cord-028721-x6f26ahr 4436 17 the the DT cord-028721-x6f26ahr 4436 18 number number NN cord-028721-x6f26ahr 4436 19 of of IN cord-028721-x6f26ahr 4436 20 MOPP MOPP NNP cord-028721-x6f26ahr 4436 21 courses course NNS cord-028721-x6f26ahr 4436 22 reduces reduce VBZ cord-028721-x6f26ahr 4436 23 gonadal gonadal JJ cord-028721-x6f26ahr 4436 24 damage damage NN cord-028721-x6f26ahr 4436 25 in in IN cord-028721-x6f26ahr 4436 26 survivors survivor NNS cord-028721-x6f26ahr 4436 27 of of IN cord-028721-x6f26ahr 4436 28 childhood childhood NN cord-028721-x6f26ahr 4436 29 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 4436 30 disease disease NN cord-028721-x6f26ahr 4436 31 Effects effect NNS cord-028721-x6f26ahr 4436 32 of of IN cord-028721-x6f26ahr 4436 33 the the DT cord-028721-x6f26ahr 4436 34 chemotherapy chemotherapy NN cord-028721-x6f26ahr 4436 35 cocktail cocktail NN cord-028721-x6f26ahr 4436 36 used use VBN cord-028721-x6f26ahr 4436 37 to to TO cord-028721-x6f26ahr 4436 38 treat treat VB cord-028721-x6f26ahr 4436 39 testicular testicular JJ cord-028721-x6f26ahr 4436 40 cancer cancer NN cord-028721-x6f26ahr 4436 41 on on IN cord-028721-x6f26ahr 4436 42 sperm sperm NN cord-028721-x6f26ahr 4436 43 chromatin chromatin NN cord-028721-x6f26ahr 4436 44 integrity integrity NN cord-028721-x6f26ahr 4436 45 Sperm sperm NN cord-028721-x6f26ahr 4436 46 integrity integrity NN cord-028721-x6f26ahr 4436 47 pre pre VBD cord-028721-x6f26ahr 4436 48 - - : cord-028721-x6f26ahr 4436 49 and and CC cord-028721-x6f26ahr 4436 50 postchemotherapy postchemotherapy NN cord-028721-x6f26ahr 4436 51 in in IN cord-028721-x6f26ahr 4436 52 men man NNS cord-028721-x6f26ahr 4436 53 with with IN cord-028721-x6f26ahr 4436 54 testicular testicular JJ cord-028721-x6f26ahr 4436 55 germ germ NN cord-028721-x6f26ahr 4436 56 cell cell NN cord-028721-x6f26ahr 4436 57 cancer cancer NN cord-028721-x6f26ahr 4436 58 Testicular Testicular NNP cord-028721-x6f26ahr 4436 59 dysfunction dysfunction NN cord-028721-x6f26ahr 4436 60 in in IN cord-028721-x6f26ahr 4436 61 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 4436 62 's 's POS cord-028721-x6f26ahr 4436 63 disease disease NN cord-028721-x6f26ahr 4436 64 before before RB cord-028721-x6f26ahr 4436 65 and and CC cord-028721-x6f26ahr 4436 66 after after IN cord-028721-x6f26ahr 4436 67 treatment treatment NN cord-028721-x6f26ahr 4436 68 Posttreatment Posttreatment NNP cord-028721-x6f26ahr 4436 69 fertility fertility NN cord-028721-x6f26ahr 4436 70 in in IN cord-028721-x6f26ahr 4436 71 patients patient NNS cord-028721-x6f26ahr 4436 72 with with IN cord-028721-x6f26ahr 4436 73 testicular testicular JJ cord-028721-x6f26ahr 4436 74 cancer cancer NN cord-028721-x6f26ahr 4436 75 . . . cord-028721-x6f26ahr 4437 1 Part part NN cord-028721-x6f26ahr 4437 2 1 1 CD cord-028721-x6f26ahr 4437 3 Sexual sexual JJ cord-028721-x6f26ahr 4437 4 function function NN cord-028721-x6f26ahr 4437 5 after after IN cord-028721-x6f26ahr 4437 6 bilateral bilateral JJ cord-028721-x6f26ahr 4437 7 retroperitoneal retroperitoneal JJ cord-028721-x6f26ahr 4437 8 lymph lymph NN cord-028721-x6f26ahr 4437 9 node node NN cord-028721-x6f26ahr 4437 10 dissection dissection NN cord-028721-x6f26ahr 4437 11 for for IN cord-028721-x6f26ahr 4437 12 nonseminomatous nonseminomatous JJ cord-028721-x6f26ahr 4437 13 testicular testicular NNP cord-028721-x6f26ahr 4437 14 cancer cancer NN cord-028721-x6f26ahr 4437 15 Sexual sexual JJ cord-028721-x6f26ahr 4437 16 dysfunction dysfunction NN cord-028721-x6f26ahr 4437 17 and and CC cord-028721-x6f26ahr 4437 18 electroejaculation electroejaculation NN cord-028721-x6f26ahr 4437 19 in in IN cord-028721-x6f26ahr 4437 20 men man NNS cord-028721-x6f26ahr 4437 21 with with IN cord-028721-x6f26ahr 4437 22 spinal spinal JJ cord-028721-x6f26ahr 4437 23 cord cord NN cord-028721-x6f26ahr 4437 24 injury injury NN cord-028721-x6f26ahr 4437 25 : : : cord-028721-x6f26ahr 4437 26 review review VB cord-028721-x6f26ahr 4437 27 Infertilty Infertilty NNP cord-028721-x6f26ahr 4437 28 in in IN cord-028721-x6f26ahr 4437 29 the the DT cord-028721-x6f26ahr 4437 30 spinal spinal JJ cord-028721-x6f26ahr 4437 31 cord cord NN cord-028721-x6f26ahr 4437 32 injuried injurie VBN cord-028721-x6f26ahr 4437 33 male male JJ cord-028721-x6f26ahr 4437 34 Reproductive reproductive JJ cord-028721-x6f26ahr 4437 35 biology biology NN cord-028721-x6f26ahr 4437 36 of of IN cord-028721-x6f26ahr 4437 37 paraplegics paraplegic NNS cord-028721-x6f26ahr 4437 38 : : : cord-028721-x6f26ahr 4437 39 Results result NNS cord-028721-x6f26ahr 4437 40 of of IN cord-028721-x6f26ahr 4437 41 semen semen NN cord-028721-x6f26ahr 4437 42 collection collection NN cord-028721-x6f26ahr 4437 43 , , , cord-028721-x6f26ahr 4437 44 testicular testicular JJ cord-028721-x6f26ahr 4437 45 biopsy biopsy NN cord-028721-x6f26ahr 4437 46 and and CC cord-028721-x6f26ahr 4437 47 serum serum NN cord-028721-x6f26ahr 4437 48 hormone hormone NN cord-028721-x6f26ahr 4437 49 evaluation evaluation NN cord-028721-x6f26ahr 4437 50 Auto auto NN cord-028721-x6f26ahr 4437 51 - - HYPH cord-028721-x6f26ahr 4437 52 immunity immunity NN cord-028721-x6f26ahr 4437 53 to to IN cord-028721-x6f26ahr 4437 54 spermatozoa spermatozoa NN cord-028721-x6f26ahr 4437 55 and and CC cord-028721-x6f26ahr 4437 56 quality quality NN cord-028721-x6f26ahr 4437 57 of of IN cord-028721-x6f26ahr 4437 58 semen semen NN cord-028721-x6f26ahr 4437 59 in in IN cord-028721-x6f26ahr 4437 60 men man NNS cord-028721-x6f26ahr 4437 61 with with IN cord-028721-x6f26ahr 4437 62 spinal spinal JJ cord-028721-x6f26ahr 4437 63 cord cord NN cord-028721-x6f26ahr 4437 64 injury injury NN cord-028721-x6f26ahr 4437 65 Histological Histological NNP cord-028721-x6f26ahr 4437 66 and and CC cord-028721-x6f26ahr 4437 67 hormonal hormonal JJ cord-028721-x6f26ahr 4437 68 testicular testicular JJ cord-028721-x6f26ahr 4437 69 changes change NNS cord-028721-x6f26ahr 4437 70 in in IN cord-028721-x6f26ahr 4437 71 spinal spinal JJ cord-028721-x6f26ahr 4437 72 cord cord NN cord-028721-x6f26ahr 4437 73 patients patient NNS cord-028721-x6f26ahr 4437 74 Male male JJ cord-028721-x6f26ahr 4437 75 fertility fertility NN cord-028721-x6f26ahr 4437 76 and and CC cord-028721-x6f26ahr 4437 77 sexual sexual JJ cord-028721-x6f26ahr 4437 78 function function NN cord-028721-x6f26ahr 4437 79 after after IN cord-028721-x6f26ahr 4437 80 spinal spinal JJ cord-028721-x6f26ahr 4437 81 cord cord NN cord-028721-x6f26ahr 4437 82 injury injury NN cord-028721-x6f26ahr 4437 83 Current current JJ cord-028721-x6f26ahr 4437 84 trends trend NNS cord-028721-x6f26ahr 4437 85 in in IN cord-028721-x6f26ahr 4437 86 the the DT cord-028721-x6f26ahr 4437 87 treatment treatment NN cord-028721-x6f26ahr 4437 88 of of IN cord-028721-x6f26ahr 4437 89 infertility infertility NN cord-028721-x6f26ahr 4437 90 in in IN cord-028721-x6f26ahr 4437 91 men man NNS cord-028721-x6f26ahr 4437 92 with with IN cord-028721-x6f26ahr 4437 93 spinal spinal JJ cord-028721-x6f26ahr 4437 94 cord cord NN cord-028721-x6f26ahr 4437 95 injury injury NN cord-028721-x6f26ahr 4438 1 Spermatogenese Spermatogenese NNP cord-028721-x6f26ahr 4438 2 bei bei NNP cord-028721-x6f26ahr 4438 3 Patienten Patienten NNP cord-028721-x6f26ahr 4438 4 mit mit VBP cord-028721-x6f26ahr 4438 5 traumatischer traumatischer NN cord-028721-x6f26ahr 4438 6 Querschnittähmung Querschnittähmung NNP cord-028721-x6f26ahr 4438 7 Deep Deep NNP cord-028721-x6f26ahr 4438 8 scrotal scrotal JJ cord-028721-x6f26ahr 4438 9 temperature temperature NN cord-028721-x6f26ahr 4438 10 and and CC cord-028721-x6f26ahr 4438 11 the the DT cord-028721-x6f26ahr 4438 12 effect effect NN cord-028721-x6f26ahr 4438 13 on on IN cord-028721-x6f26ahr 4438 14 it -PRON- PRP cord-028721-x6f26ahr 4438 15 of of IN cord-028721-x6f26ahr 4438 16 clothing clothing NN cord-028721-x6f26ahr 4438 17 , , , cord-028721-x6f26ahr 4438 18 air air NN cord-028721-x6f26ahr 4438 19 , , , cord-028721-x6f26ahr 4438 20 temperature temperature NN cord-028721-x6f26ahr 4438 21 , , , cord-028721-x6f26ahr 4438 22 activity activity NN cord-028721-x6f26ahr 4438 23 , , , cord-028721-x6f26ahr 4438 24 posture posture NN cord-028721-x6f26ahr 4438 25 and and CC cord-028721-x6f26ahr 4438 26 paraplegia paraplegia NN cord-028721-x6f26ahr 4439 1 Neurological neurological JJ cord-028721-x6f26ahr 4439 2 correlations correlation NNS cord-028721-x6f26ahr 4439 3 of of IN cord-028721-x6f26ahr 4439 4 ejaculation ejaculation NN cord-028721-x6f26ahr 4439 5 and and CC cord-028721-x6f26ahr 4439 6 testicular testicular JJ cord-028721-x6f26ahr 4439 7 size size NN cord-028721-x6f26ahr 4439 8 in in IN cord-028721-x6f26ahr 4439 9 men man NNS cord-028721-x6f26ahr 4439 10 with with IN cord-028721-x6f26ahr 4439 11 a a DT cord-028721-x6f26ahr 4439 12 complete complete JJ cord-028721-x6f26ahr 4439 13 spinal spinal JJ cord-028721-x6f26ahr 4439 14 cord cord NN cord-028721-x6f26ahr 4439 15 section section NN cord-028721-x6f26ahr 4439 16 Leukocytes Leukocytes NNP cord-028721-x6f26ahr 4439 17 in in IN cord-028721-x6f26ahr 4439 18 semen semen NN cord-028721-x6f26ahr 4439 19 from from IN cord-028721-x6f26ahr 4439 20 men man NNS cord-028721-x6f26ahr 4439 21 with with IN cord-028721-x6f26ahr 4439 22 spinal spinal JJ cord-028721-x6f26ahr 4439 23 cord cord NN cord-028721-x6f26ahr 4439 24 injuries injury NNS cord-028721-x6f26ahr 4440 1 Leukocyte Leukocyte NNP cord-028721-x6f26ahr 4440 2 subtypes subtype NNS cord-028721-x6f26ahr 4440 3 in in IN cord-028721-x6f26ahr 4440 4 electroejaculates electroejaculate NNS cord-028721-x6f26ahr 4440 5 of of IN cord-028721-x6f26ahr 4440 6 spinal spinal JJ cord-028721-x6f26ahr 4440 7 cord cord NN cord-028721-x6f26ahr 4440 8 injured injure VBN cord-028721-x6f26ahr 4440 9 men man NNS cord-028721-x6f26ahr 4440 10 Infl Infl NNP cord-028721-x6f26ahr 4440 11 ammatory ammatory NNP cord-028721-x6f26ahr 4440 12 cytokine cytokine NN cord-028721-x6f26ahr 4440 13 concentrations concentration NNS cord-028721-x6f26ahr 4440 14 are be VBP cord-028721-x6f26ahr 4440 15 elevated elevate VBN cord-028721-x6f26ahr 4440 16 in in IN cord-028721-x6f26ahr 4440 17 seminal seminal JJ cord-028721-x6f26ahr 4440 18 plasma plasma NN cord-028721-x6f26ahr 4440 19 of of IN cord-028721-x6f26ahr 4440 20 men man NNS cord-028721-x6f26ahr 4440 21 with with IN cord-028721-x6f26ahr 4440 22 spinal spinal JJ cord-028721-x6f26ahr 4440 23 cord cord NN cord-028721-x6f26ahr 4440 24 injuries injury NNS cord-028721-x6f26ahr 4441 1 Testis Testis NNP cord-028721-x6f26ahr 4441 2 biopsy biopsy NN cord-028721-x6f26ahr 4441 3 fi fi NN cord-028721-x6f26ahr 4441 4 ndings nding NNS cord-028721-x6f26ahr 4441 5 in in IN cord-028721-x6f26ahr 4441 6 the the DT cord-028721-x6f26ahr 4441 7 spinal spinal JJ cord-028721-x6f26ahr 4441 8 cord cord NN cord-028721-x6f26ahr 4441 9 injured injure VBN cord-028721-x6f26ahr 4441 10 patient patient NN cord-028721-x6f26ahr 4441 11 Seminal seminal JJ cord-028721-x6f26ahr 4441 12 vesicle vesicle NN cord-028721-x6f26ahr 4441 13 aspiration aspiration NN cord-028721-x6f26ahr 4441 14 in in IN cord-028721-x6f26ahr 4441 15 spinal spinal JJ cord-028721-x6f26ahr 4441 16 cord cord NN cord-028721-x6f26ahr 4441 17 injured injure VBN cord-028721-x6f26ahr 4441 18 men man NNS cord-028721-x6f26ahr 4441 19 : : : cord-028721-x6f26ahr 4441 20 insight insight NN cord-028721-x6f26ahr 4441 21 into into IN cord-028721-x6f26ahr 4441 22 poor poor JJ cord-028721-x6f26ahr 4441 23 sperm sperm NN cord-028721-x6f26ahr 4441 24 quality quality NN cord-028721-x6f26ahr 4441 25 Sperm sperm NN cord-028721-x6f26ahr 4441 26 motility motility NN cord-028721-x6f26ahr 4441 27 from from IN cord-028721-x6f26ahr 4441 28 the the DT cord-028721-x6f26ahr 4441 29 vas vas NNP cord-028721-x6f26ahr 4441 30 deferens deferens NN cord-028721-x6f26ahr 4441 31 of of IN cord-028721-x6f26ahr 4441 32 spinal spinal JJ cord-028721-x6f26ahr 4441 33 cord cord NN cord-028721-x6f26ahr 4441 34 injured injure VBN cord-028721-x6f26ahr 4441 35 men man NNS cord-028721-x6f26ahr 4441 36 is be VBZ cord-028721-x6f26ahr 4441 37 higher high JJR cord-028721-x6f26ahr 4441 38 than than IN cord-028721-x6f26ahr 4441 39 from from IN cord-028721-x6f26ahr 4441 40 the the DT cord-028721-x6f26ahr 4441 41 ejaculate ejaculate JJ cord-028721-x6f26ahr 4441 42 Brown Brown NNP cord-028721-x6f26ahr 4441 43 - - HYPH cord-028721-x6f26ahr 4441 44 colored color VBN cord-028721-x6f26ahr 4441 45 semen semen NN cord-028721-x6f26ahr 4441 46 in in IN cord-028721-x6f26ahr 4441 47 men man NNS cord-028721-x6f26ahr 4441 48 with with IN cord-028721-x6f26ahr 4441 49 spinal spinal JJ cord-028721-x6f26ahr 4441 50 cord cord NN cord-028721-x6f26ahr 4441 51 injury injury NN cord-028721-x6f26ahr 4441 52 Mumps Mumps NNP cord-028721-x6f26ahr 4441 53 orchitis orchitis NN cord-028721-x6f26ahr 4441 54 : : : cord-028721-x6f26ahr 4442 1 report report NN cord-028721-x6f26ahr 4442 2 of of IN cord-028721-x6f26ahr 4442 3 a a DT cord-028721-x6f26ahr 4442 4 mini mini JJ cord-028721-x6f26ahr 4442 5 - - JJ cord-028721-x6f26ahr 4442 6 epidemic epidemic JJ cord-028721-x6f26ahr 4442 7 Mumps Mumps NNP cord-028721-x6f26ahr 4442 8 orchitis orchitis NN cord-028721-x6f26ahr 4442 9 Mumps Mumps NNP cord-028721-x6f26ahr 4442 10 -an -an NNS cord-028721-x6f26ahr 4442 11 underestimated underestimate VBD cord-028721-x6f26ahr 4442 12 disease disease NN cord-028721-x6f26ahr 4442 13 Mumps Mumps NNP cord-028721-x6f26ahr 4442 14 orchitis orchitis NN cord-028721-x6f26ahr 4442 15 among among IN cord-028721-x6f26ahr 4442 16 soldiers soldier NNS cord-028721-x6f26ahr 4442 17 : : : cord-028721-x6f26ahr 4442 18 frequency frequency NN cord-028721-x6f26ahr 4442 19 , , , cord-028721-x6f26ahr 4442 20 effect effect NN cord-028721-x6f26ahr 4442 21 on on IN cord-028721-x6f26ahr 4442 22 sperm sperm NN cord-028721-x6f26ahr 4442 23 quality quality NN cord-028721-x6f26ahr 4442 24 , , , cord-028721-x6f26ahr 4442 25 and and CC cord-028721-x6f26ahr 4442 26 sperm sperm NN cord-028721-x6f26ahr 4442 27 antibodies antibody NNS cord-028721-x6f26ahr 4442 28 Mumps Mumps NNP cord-028721-x6f26ahr 4442 29 orchitis orchiti NNS cord-028721-x6f26ahr 4442 30 : : : cord-028721-x6f26ahr 4442 31 symptoms symptom NNS cord-028721-x6f26ahr 4442 32 and and CC cord-028721-x6f26ahr 4442 33 treatment treatment NN cord-028721-x6f26ahr 4442 34 possibilities possibility NNS cord-028721-x6f26ahr 4442 35 Pathology Pathology NNP cord-028721-x6f26ahr 4442 36 of of IN cord-028721-x6f26ahr 4442 37 mumps mumps NN cord-028721-x6f26ahr 4442 38 orchitis orchitis NN cord-028721-x6f26ahr 4443 1 Successful successful JJ cord-028721-x6f26ahr 4443 2 testicular testicular JJ cord-028721-x6f26ahr 4443 3 sperm sperm NN cord-028721-x6f26ahr 4443 4 extraction extraction NN cord-028721-x6f26ahr 4443 5 and and CC cord-028721-x6f26ahr 4443 6 fertilization fertilization NN cord-028721-x6f26ahr 4443 7 in in IN cord-028721-x6f26ahr 4443 8 an an DT cord-028721-x6f26ahr 4443 9 azoospermic azoospermic JJ cord-028721-x6f26ahr 4443 10 man man NN cord-028721-x6f26ahr 4443 11 with with IN cord-028721-x6f26ahr 4443 12 postpubertal postpubertal JJ cord-028721-x6f26ahr 4443 13 mumps mumps NN cord-028721-x6f26ahr 4443 14 orchitis orchitis NN cord-028721-x6f26ahr 4443 15 Infl Infl NNP cord-028721-x6f26ahr 4443 16 ammation ammation NN cord-028721-x6f26ahr 4443 17 of of IN cord-028721-x6f26ahr 4443 18 the the DT cord-028721-x6f26ahr 4443 19 testis testis NN cord-028721-x6f26ahr 4443 20 , , , cord-028721-x6f26ahr 4443 21 epididymis epididymis NN cord-028721-x6f26ahr 4443 22 , , , cord-028721-x6f26ahr 4443 23 peritesticular peritesticular JJ cord-028721-x6f26ahr 4443 24 membranes membrane NNS cord-028721-x6f26ahr 4443 25 and and CC cord-028721-x6f26ahr 4443 26 scrotum scrotum NNP cord-028721-x6f26ahr 4443 27 Orchitis Orchitis NNP cord-028721-x6f26ahr 4443 28 and and CC cord-028721-x6f26ahr 4443 29 testicular testicular JJ cord-028721-x6f26ahr 4443 30 abscess abscess NN cord-028721-x6f26ahr 4443 31 formation formation NN cord-028721-x6f26ahr 4443 32 caused cause VBN cord-028721-x6f26ahr 4443 33 by by IN cord-028721-x6f26ahr 4443 34 non non JJ cord-028721-x6f26ahr 4443 35 - - JJ cord-028721-x6f26ahr 4443 36 typhoid typhoid JJ cord-028721-x6f26ahr 4443 37 salmonellosis salmonellosis NN cord-028721-x6f26ahr 4443 38 Disseminated disseminate VBD cord-028721-x6f26ahr 4443 39 actinomycosis actinomycosis NN cord-028721-x6f26ahr 4443 40 presenting present VBG cord-028721-x6f26ahr 4443 41 as as IN cord-028721-x6f26ahr 4443 42 a a DT cord-028721-x6f26ahr 4443 43 testicular testicular JJ cord-028721-x6f26ahr 4443 44 mass mass NN cord-028721-x6f26ahr 4443 45 . . . cord-028721-x6f26ahr 4444 1 A a DT cord-028721-x6f26ahr 4444 2 case case NN cord-028721-x6f26ahr 4444 3 report report NN cord-028721-x6f26ahr 4444 4 Primary primary JJ cord-028721-x6f26ahr 4444 5 testicular testicular JJ cord-028721-x6f26ahr 4444 6 actinomycosis actinomycosis NN cord-028721-x6f26ahr 4444 7 mimicking mimic VBG cord-028721-x6f26ahr 4444 8 metastatic metastatic JJ cord-028721-x6f26ahr 4444 9 tumor tumor NN cord-028721-x6f26ahr 4445 1 Xanthogranulomatous Xanthogranulomatous NNP cord-028721-x6f26ahr 4445 2 funiculitis funiculitis NNP cord-028721-x6f26ahr 4445 3 and and CC cord-028721-x6f26ahr 4445 4 orchiepididymitis orchiepididymitis NNP cord-028721-x6f26ahr 4445 5 : : : cord-028721-x6f26ahr 4445 6 report report VB cord-028721-x6f26ahr 4445 7 of of IN cord-028721-x6f26ahr 4445 8 2 2 CD cord-028721-x6f26ahr 4445 9 cases case NNS cord-028721-x6f26ahr 4445 10 with with IN cord-028721-x6f26ahr 4445 11 immunohistochemical immunohistochemical JJ cord-028721-x6f26ahr 4445 12 study study NN cord-028721-x6f26ahr 4445 13 and and CC cord-028721-x6f26ahr 4445 14 literature literature NN cord-028721-x6f26ahr 4445 15 review review NN cord-028721-x6f26ahr 4446 1 Tuberculous tuberculous JJ cord-028721-x6f26ahr 4446 2 epididymitis epididymitis NN cord-028721-x6f26ahr 4446 3 occurring occur VBG cord-028721-x6f26ahr 4446 4 35 35 CD cord-028721-x6f26ahr 4446 5 years year NNS cord-028721-x6f26ahr 4446 6 after after IN cord-028721-x6f26ahr 4446 7 renal renal JJ cord-028721-x6f26ahr 4446 8 tuberculosis tuberculosis NN cord-028721-x6f26ahr 4446 9 Tuberculous Tuberculous NNP cord-028721-x6f26ahr 4446 10 epididymitis epididymitis NN cord-028721-x6f26ahr 4446 11 as as IN cord-028721-x6f26ahr 4446 12 a a DT cord-028721-x6f26ahr 4446 13 cause cause NN cord-028721-x6f26ahr 4446 14 of of IN cord-028721-x6f26ahr 4446 15 testicular testicular JJ cord-028721-x6f26ahr 4446 16 pseudomalignancy pseudomalignancy NN cord-028721-x6f26ahr 4446 17 in in IN cord-028721-x6f26ahr 4446 18 two two CD cord-028721-x6f26ahr 4446 19 young young JJ cord-028721-x6f26ahr 4446 20 children child NNS cord-028721-x6f26ahr 4446 21 Tuberculous Tuberculous NNP cord-028721-x6f26ahr 4446 22 epididymo epididymo NN cord-028721-x6f26ahr 4446 23 - - HYPH cord-028721-x6f26ahr 4446 24 orchitis orchitis NN cord-028721-x6f26ahr 4446 25 . . . cord-028721-x6f26ahr 4447 1 Diagnosis diagnosis NN cord-028721-x6f26ahr 4447 2 by by IN cord-028721-x6f26ahr 4447 3 fi fi NNP cord-028721-x6f26ahr 4447 4 ne ne NNP cord-028721-x6f26ahr 4447 5 needle needle NN cord-028721-x6f26ahr 4447 6 aspiration aspiration NN cord-028721-x6f26ahr 4447 7 Tuberculous Tuberculous NNP cord-028721-x6f26ahr 4447 8 epididymo epididymo NN cord-028721-x6f26ahr 4447 9 - - HYPH cord-028721-x6f26ahr 4447 10 orchitis orchitis NN cord-028721-x6f26ahr 4447 11 . . . cord-028721-x6f26ahr 4448 1 A a DT cord-028721-x6f26ahr 4448 2 case case NN cord-028721-x6f26ahr 4448 3 report report NN cord-028721-x6f26ahr 4448 4 Epididymo Epididymo NNP cord-028721-x6f26ahr 4448 5 - - HYPH cord-028721-x6f26ahr 4448 6 orchitis orchitis NN cord-028721-x6f26ahr 4448 7 caused cause VBN cord-028721-x6f26ahr 4448 8 by by IN cord-028721-x6f26ahr 4448 9 intravesically intravesically RB cord-028721-x6f26ahr 4448 10 instillated instillated JJ cord-028721-x6f26ahr 4448 11 bacillus bacillus NN cord-028721-x6f26ahr 4448 12 Calmette Calmette NNP cord-028721-x6f26ahr 4448 13 - - HYPH cord-028721-x6f26ahr 4448 14 Guérin Guérin NNP cord-028721-x6f26ahr 4448 15 : : : cord-028721-x6f26ahr 4448 16 genetically genetically RB cord-028721-x6f26ahr 4448 17 proven prove VBN cord-028721-x6f26ahr 4448 18 using use VBG cord-028721-x6f26ahr 4448 19 a a DT cord-028721-x6f26ahr 4448 20 multiplex multiplex JJ cord-028721-x6f26ahr 4448 21 polymerase polymerase NN cord-028721-x6f26ahr 4448 22 chain chain NN cord-028721-x6f26ahr 4448 23 reaction reaction NN cord-028721-x6f26ahr 4448 24 method method NN cord-028721-x6f26ahr 4448 25 Gumma Gumma NNP cord-028721-x6f26ahr 4448 26 of of IN cord-028721-x6f26ahr 4448 27 testis testis NN cord-028721-x6f26ahr 4448 28 Lepromatous lepromatous JJ cord-028721-x6f26ahr 4448 29 leprosy leprosy NN cord-028721-x6f26ahr 4448 30 presenting present VBG cord-028721-x6f26ahr 4448 31 as as IN cord-028721-x6f26ahr 4448 32 orchitis orchitis NN cord-028721-x6f26ahr 4448 33 Clinicopathological Clinicopathological NNP cord-028721-x6f26ahr 4448 34 study study NN cord-028721-x6f26ahr 4448 35 of of IN cord-028721-x6f26ahr 4448 36 testicular testicular JJ cord-028721-x6f26ahr 4448 37 involvement involvement NN cord-028721-x6f26ahr 4448 38 in in IN cord-028721-x6f26ahr 4448 39 leprosy leprosy NN cord-028721-x6f26ahr 4449 1 Genital genital JJ cord-028721-x6f26ahr 4449 2 manifestations manifestation NNS cord-028721-x6f26ahr 4449 3 of of IN cord-028721-x6f26ahr 4449 4 tropical tropical JJ cord-028721-x6f26ahr 4449 5 diseases disease NNS cord-028721-x6f26ahr 4449 6 Human human JJ cord-028721-x6f26ahr 4449 7 brucellosis brucellosis NN cord-028721-x6f26ahr 4449 8 in in IN cord-028721-x6f26ahr 4449 9 Northern Northern NNP cord-028721-x6f26ahr 4449 10 Saudi Saudi NNP cord-028721-x6f26ahr 4449 11 Arabia Arabia NNP cord-028721-x6f26ahr 4449 12 Epididymoorchitis Epididymoorchitis NNP cord-028721-x6f26ahr 4449 13 due due IN cord-028721-x6f26ahr 4449 14 to to IN cord-028721-x6f26ahr 4449 15 brucellosis brucellosis NN cord-028721-x6f26ahr 4449 16 in in IN cord-028721-x6f26ahr 4449 17 central central JJ cord-028721-x6f26ahr 4449 18 Anatolia Anatolia NNP cord-028721-x6f26ahr 4449 19 Brucellar Brucellar NNP cord-028721-x6f26ahr 4449 20 orchiepididymitis orchiepididymitis NN cord-028721-x6f26ahr 4449 21 in in IN cord-028721-x6f26ahr 4449 22 acute acute JJ cord-028721-x6f26ahr 4449 23 brucellosis brucellosis NN cord-028721-x6f26ahr 4449 24 Brucella Brucella NNP cord-028721-x6f26ahr 4449 25 orchitis orchitis NN cord-028721-x6f26ahr 4449 26 : : : cord-028721-x6f26ahr 4449 27 a a DT cord-028721-x6f26ahr 4449 28 rare rare JJ cord-028721-x6f26ahr 4449 29 cause cause NN cord-028721-x6f26ahr 4449 30 of of IN cord-028721-x6f26ahr 4449 31 testicular testicular JJ cord-028721-x6f26ahr 4449 32 enlargement enlargement NN cord-028721-x6f26ahr 4450 1 Orquioepididimitis Orquioepididimitis NNP cord-028721-x6f26ahr 4450 2 brucelosa brucelosa RB cord-028721-x6f26ahr 4450 3 : : : cord-028721-x6f26ahr 4451 1 A a DT cord-028721-x6f26ahr 4451 2 propósito propósito FW cord-028721-x6f26ahr 4451 3 de de FW cord-028721-x6f26ahr 4451 4 un un NNP cord-028721-x6f26ahr 4451 5 caso caso NNP cord-028721-x6f26ahr 4451 6 Rapid Rapid NNP cord-028721-x6f26ahr 4451 7 diagnosis diagnosis NN cord-028721-x6f26ahr 4451 8 of of IN cord-028721-x6f26ahr 4451 9 Brucella Brucella NNP cord-028721-x6f26ahr 4451 10 epididymo epididymo NN cord-028721-x6f26ahr 4451 11 - - HYPH cord-028721-x6f26ahr 4451 12 orchitis orchitis NN cord-028721-x6f26ahr 4451 13 by by IN cord-028721-x6f26ahr 4451 14 realtime realtime JJ cord-028721-x6f26ahr 4451 15 polymerase polymerase NN cord-028721-x6f26ahr 4451 16 chain chain NN cord-028721-x6f26ahr 4451 17 reaction reaction NN cord-028721-x6f26ahr 4451 18 assay assay NN cord-028721-x6f26ahr 4451 19 in in IN cord-028721-x6f26ahr 4451 20 urine urine NN cord-028721-x6f26ahr 4451 21 samples sample NNS cord-028721-x6f26ahr 4451 22 Epididymal Epididymal NNP cord-028721-x6f26ahr 4451 23 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 4451 24 Sarcoidosis sarcoidosi NNS cord-028721-x6f26ahr 4451 25 with with IN cord-028721-x6f26ahr 4451 26 bilateral bilateral JJ cord-028721-x6f26ahr 4451 27 epididymal epididymal JJ cord-028721-x6f26ahr 4451 28 and and CC cord-028721-x6f26ahr 4451 29 testicular testicular JJ cord-028721-x6f26ahr 4451 30 lesions lesion NNS cord-028721-x6f26ahr 4451 31 Sarcoidosis sarcoidosi NNS cord-028721-x6f26ahr 4451 32 presenting present VBG cord-028721-x6f26ahr 4451 33 as as IN cord-028721-x6f26ahr 4451 34 a a DT cord-028721-x6f26ahr 4451 35 testicular testicular JJ cord-028721-x6f26ahr 4451 36 mass mass NN cord-028721-x6f26ahr 4451 37 Sarcoid Sarcoid NNP cord-028721-x6f26ahr 4451 38 of of IN cord-028721-x6f26ahr 4451 39 the the DT cord-028721-x6f26ahr 4451 40 testis testis NN cord-028721-x6f26ahr 4451 41 Genitourinary Genitourinary NNP cord-028721-x6f26ahr 4451 42 involvement involvement NN cord-028721-x6f26ahr 4451 43 of of IN cord-028721-x6f26ahr 4451 44 systemic systemic JJ cord-028721-x6f26ahr 4451 45 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 4451 46 confi confi NNP cord-028721-x6f26ahr 4451 47 ned ned NNP cord-028721-x6f26ahr 4451 48 to to IN cord-028721-x6f26ahr 4451 49 testicle testicle NN cord-028721-x6f26ahr 4451 50 Seminoma Seminoma NNP cord-028721-x6f26ahr 4451 51 and and CC cord-028721-x6f26ahr 4451 52 sarcoidosis sarcoidosis NNP cord-028721-x6f26ahr 4451 53 : : : cord-028721-x6f26ahr 4451 54 an an DT cord-028721-x6f26ahr 4451 55 unusual unusual JJ cord-028721-x6f26ahr 4451 56 association association NN cord-028721-x6f26ahr 4451 57 Intermittent intermittent JJ cord-028721-x6f26ahr 4451 58 azoospermia azoospermia NN cord-028721-x6f26ahr 4451 59 associated associate VBN cord-028721-x6f26ahr 4451 60 with with IN cord-028721-x6f26ahr 4451 61 epididymal epididymal JJ cord-028721-x6f26ahr 4451 62 sarcoidosis sarcoidosis NN cord-028721-x6f26ahr 4451 63 Ueber Ueber NNP cord-028721-x6f26ahr 4451 64 Einschlüsse Einschlüsse NNP cord-028721-x6f26ahr 4451 65 in in IN cord-028721-x6f26ahr 4451 66 Blastumoren Blastumoren NNP cord-028721-x6f26ahr 4452 1 A a DT cord-028721-x6f26ahr 4452 2 case case NN cord-028721-x6f26ahr 4452 3 of of IN cord-028721-x6f26ahr 4452 4 malacoplakia malacoplakia NN cord-028721-x6f26ahr 4452 5 of of IN cord-028721-x6f26ahr 4452 6 the the DT cord-028721-x6f26ahr 4452 7 epididymis epididymis NN cord-028721-x6f26ahr 4452 8 associated associate VBN cord-028721-x6f26ahr 4452 9 with with IN cord-028721-x6f26ahr 4452 10 trauma trauma NN cord-028721-x6f26ahr 4452 11 Epididymo Epididymo NNP cord-028721-x6f26ahr 4452 12 - - HYPH cord-028721-x6f26ahr 4452 13 testicular testicular JJ cord-028721-x6f26ahr 4452 14 malacoplakiaa malacoplakiaa NN cord-028721-x6f26ahr 4452 15 case case NN cord-028721-x6f26ahr 4452 16 report report VBP cord-028721-x6f26ahr 4452 17 An an DT cord-028721-x6f26ahr 4452 18 unusual unusual JJ cord-028721-x6f26ahr 4452 19 case case NN cord-028721-x6f26ahr 4452 20 of of IN cord-028721-x6f26ahr 4452 21 malakoplakia malakoplakia NN cord-028721-x6f26ahr 4452 22 involving involve VBG cord-028721-x6f26ahr 4452 23 the the DT cord-028721-x6f26ahr 4452 24 testis testis NN cord-028721-x6f26ahr 4452 25 and and CC cord-028721-x6f26ahr 4452 26 prostate prostate NN cord-028721-x6f26ahr 4452 27 Testicular Testicular NNP cord-028721-x6f26ahr 4452 28 malacoplakia malacoplakia NN cord-028721-x6f26ahr 4452 29 Septate Septate NNP cord-028721-x6f26ahr 4452 30 junctions junction NNS cord-028721-x6f26ahr 4452 31 between between IN cord-028721-x6f26ahr 4452 32 digestive digestive JJ cord-028721-x6f26ahr 4452 33 vacuoles vacuole NNS cord-028721-x6f26ahr 4452 34 in in IN cord-028721-x6f26ahr 4452 35 human human JJ cord-028721-x6f26ahr 4452 36 malakoplakia malakoplakia NN cord-028721-x6f26ahr 4452 37 Genitourinary Genitourinary NNP cord-028721-x6f26ahr 4452 38 tract tract JJ cord-028721-x6f26ahr 4452 39 involvement involvement NN cord-028721-x6f26ahr 4452 40 with with IN cord-028721-x6f26ahr 4452 41 systemic systemic JJ cord-028721-x6f26ahr 4452 42 mycosis mycosis NNP cord-028721-x6f26ahr 4452 43 Coccidioidomycosis Coccidioidomycosis NNP cord-028721-x6f26ahr 4452 44 of of IN cord-028721-x6f26ahr 4452 45 the the DT cord-028721-x6f26ahr 4452 46 epididymis epididymis NN cord-028721-x6f26ahr 4452 47 and and CC cord-028721-x6f26ahr 4452 48 testis testis NN cord-028721-x6f26ahr 4452 49 Cryptococcal Cryptococcal NNP cord-028721-x6f26ahr 4452 50 epididymoorchitis epididymoorchitis NN cord-028721-x6f26ahr 4452 51 complicating complicate VBG cord-028721-x6f26ahr 4452 52 steroid steroid NN cord-028721-x6f26ahr 4452 53 therapy therapy NN cord-028721-x6f26ahr 4452 54 for for IN cord-028721-x6f26ahr 4452 55 releasing release VBG cord-028721-x6f26ahr 4452 56 polychondritis polychondritis NNP cord-028721-x6f26ahr 4452 57 Schistosomal Schistosomal NNP cord-028721-x6f26ahr 4452 58 epididymitis epididymitis NN cord-028721-x6f26ahr 4452 59 Alveolar alveolar NN cord-028721-x6f26ahr 4452 60 echinococcosis echinococcosis NN cord-028721-x6f26ahr 4452 61 with with IN cord-028721-x6f26ahr 4452 62 involvement involvement NN cord-028721-x6f26ahr 4452 63 of of IN cord-028721-x6f26ahr 4452 64 the the DT cord-028721-x6f26ahr 4452 65 ureter ureter NN cord-028721-x6f26ahr 4452 66 and and CC cord-028721-x6f26ahr 4452 67 testes testis NNS cord-028721-x6f26ahr 4452 68 Idiopathic idiopathic JJ cord-028721-x6f26ahr 4452 69 granulomatous granulomatous JJ cord-028721-x6f26ahr 4452 70 orchitis orchitis NN cord-028721-x6f26ahr 4452 71 : : : cord-028721-x6f26ahr 4452 72 pathologic pathologic JJ cord-028721-x6f26ahr 4452 73 study study NN cord-028721-x6f26ahr 4452 74 of of IN cord-028721-x6f26ahr 4452 75 one one CD cord-028721-x6f26ahr 4452 76 case case NN cord-028721-x6f26ahr 4452 77 Experimental experimental JJ cord-028721-x6f26ahr 4452 78 allergic allergic JJ cord-028721-x6f26ahr 4452 79 orchitis orchitis NN cord-028721-x6f26ahr 4452 80 in in IN cord-028721-x6f26ahr 4452 81 mice mouse NNS cord-028721-x6f26ahr 4452 82 . . . cord-028721-x6f26ahr 4453 1 Histopathological Histopathological NNP cord-028721-x6f26ahr 4453 2 and and CC cord-028721-x6f26ahr 4453 3 immunological immunological JJ cord-028721-x6f26ahr 4453 4 studies study NNS cord-028721-x6f26ahr 4454 1 Immunological immunological JJ cord-028721-x6f26ahr 4454 2 phenomena phenomenon NNS cord-028721-x6f26ahr 4454 3 observed observe VBN cord-028721-x6f26ahr 4454 4 in in IN cord-028721-x6f26ahr 4454 5 the the DT cord-028721-x6f26ahr 4454 6 testis testis NN cord-028721-x6f26ahr 4454 7 and and CC cord-028721-x6f26ahr 4454 8 their -PRON- PRP$ cord-028721-x6f26ahr 4454 9 possible possible JJ cord-028721-x6f26ahr 4454 10 role role NN cord-028721-x6f26ahr 4454 11 in in IN cord-028721-x6f26ahr 4454 12 infertility infertility NN cord-028721-x6f26ahr 4454 13 Immunocompetent Immunocompetent NNP cord-028721-x6f26ahr 4454 14 cells cell NNS cord-028721-x6f26ahr 4454 15 in in IN cord-028721-x6f26ahr 4454 16 human human JJ cord-028721-x6f26ahr 4454 17 testis testis NN cord-028721-x6f26ahr 4454 18 in in IN cord-028721-x6f26ahr 4454 19 health health NN cord-028721-x6f26ahr 4454 20 and and CC cord-028721-x6f26ahr 4454 21 disease disease NN cord-028721-x6f26ahr 4454 22 Sympathetic sympathetic JJ cord-028721-x6f26ahr 4454 23 autoimmune autoimmune JJ cord-028721-x6f26ahr 4454 24 orchitis orchitis NN cord-028721-x6f26ahr 4454 25 Testicular testicular JJ cord-028721-x6f26ahr 4454 26 obstruction obstruction NN cord-028721-x6f26ahr 4454 27 : : : cord-028721-x6f26ahr 4454 28 clinicopathological clinicopathological NNP cord-028721-x6f26ahr 4454 29 studies study NNS cord-028721-x6f26ahr 4454 30 Hypoechoic Hypoechoic NNP cord-028721-x6f26ahr 4454 31 Lesion Lesion NNP cord-028721-x6f26ahr 4454 32 found find VBD cord-028721-x6f26ahr 4454 33 on on IN cord-028721-x6f26ahr 4454 34 testicular testicular JJ cord-028721-x6f26ahr 4454 35 ultrasound ultrasound NN cord-028721-x6f26ahr 4454 36 after after IN cord-028721-x6f26ahr 4454 37 testicular testicular JJ cord-028721-x6f26ahr 4454 38 piercing pierce VBG cord-028721-x6f26ahr 4454 39 Focal focal JJ cord-028721-x6f26ahr 4454 40 orchitis orchitis NN cord-028721-x6f26ahr 4454 41 in in IN cord-028721-x6f26ahr 4454 42 undescended undescended JJ cord-028721-x6f26ahr 4454 43 testes testis NNS cord-028721-x6f26ahr 4454 44 : : : cord-028721-x6f26ahr 4454 45 discussion discussion NN cord-028721-x6f26ahr 4454 46 of of IN cord-028721-x6f26ahr 4454 47 pathogenetic pathogenetic JJ cord-028721-x6f26ahr 4454 48 mechanisms mechanism NNS cord-028721-x6f26ahr 4454 49 of of IN cord-028721-x6f26ahr 4454 50 tubular tubular JJ cord-028721-x6f26ahr 4454 51 atrophy atrophy NN cord-028721-x6f26ahr 4454 52 Pseudolymphoma Pseudolymphoma NNP cord-028721-x6f26ahr 4454 53 of of IN cord-028721-x6f26ahr 4454 54 the the DT cord-028721-x6f26ahr 4454 55 testis testis NN cord-028721-x6f26ahr 4454 56 Plasma plasma NN cord-028721-x6f26ahr 4454 57 cell cell NN cord-028721-x6f26ahr 4454 58 granuloma granuloma NN cord-028721-x6f26ahr 4454 59 of of IN cord-028721-x6f26ahr 4454 60 the the DT cord-028721-x6f26ahr 4454 61 testis testis NN cord-028721-x6f26ahr 4454 62 : : : cord-028721-x6f26ahr 4454 63 unusual unusual JJ cord-028721-x6f26ahr 4454 64 localization localization NN cord-028721-x6f26ahr 4454 65 Testicular Testicular NNP cord-028721-x6f26ahr 4454 66 plasmacytoma plasmacytoma NNP cord-028721-x6f26ahr 4454 67 : : : cord-028721-x6f26ahr 4454 68 report report NN cord-028721-x6f26ahr 4454 69 of of IN cord-028721-x6f26ahr 4454 70 a a DT cord-028721-x6f26ahr 4454 71 case case NN cord-028721-x6f26ahr 4454 72 and and CC cord-028721-x6f26ahr 4454 73 review review NN cord-028721-x6f26ahr 4454 74 of of IN cord-028721-x6f26ahr 4454 75 the the DT cord-028721-x6f26ahr 4454 76 literature literature NN cord-028721-x6f26ahr 4454 77 Sinus sinus NN cord-028721-x6f26ahr 4454 78 histiocytosis histiocytosis NN cord-028721-x6f26ahr 4454 79 with with IN cord-028721-x6f26ahr 4454 80 massive massive JJ cord-028721-x6f26ahr 4454 81 lymphadenopathy lymphadenopathy NN cord-028721-x6f26ahr 4454 82 ( ( -LRB- cord-028721-x6f26ahr 4454 83 Rosai Rosai NNP cord-028721-x6f26ahr 4454 84 - - HYPH cord-028721-x6f26ahr 4454 85 Dorfman Dorfman NNP cord-028721-x6f26ahr 4454 86 disease disease NN cord-028721-x6f26ahr 4454 87 ) ) -RRB- cord-028721-x6f26ahr 4454 88 : : : cord-028721-x6f26ahr 4454 89 report report VB cord-028721-x6f26ahr 4454 90 of of IN cord-028721-x6f26ahr 4454 91 a a DT cord-028721-x6f26ahr 4454 92 patient patient NN cord-028721-x6f26ahr 4454 93 with with IN cord-028721-x6f26ahr 4454 94 isolated isolate VBN cord-028721-x6f26ahr 4454 95 renotesticular renotesticular JJ cord-028721-x6f26ahr 4454 96 involvement involvement NN cord-028721-x6f26ahr 4454 97 after after IN cord-028721-x6f26ahr 4454 98 cure cure NN cord-028721-x6f26ahr 4454 99 of of IN cord-028721-x6f26ahr 4454 100 non non JJ cord-028721-x6f26ahr 4454 101 - - JJ cord-028721-x6f26ahr 4454 102 Hodgkin Hodgkin NNP cord-028721-x6f26ahr 4454 103 's 's POS cord-028721-x6f26ahr 4454 104 lymphoma lymphoma NN cord-028721-x6f26ahr 4454 105 Rosai Rosai NNP cord-028721-x6f26ahr 4454 106 - - HYPH cord-028721-x6f26ahr 4454 107 Dorfman Dorfman NNP cord-028721-x6f26ahr 4454 108 disease disease NN cord-028721-x6f26ahr 4454 109 of of IN cord-028721-x6f26ahr 4454 110 the the DT cord-028721-x6f26ahr 4454 111 testis testis NN cord-028721-x6f26ahr 4454 112 : : : cord-028721-x6f26ahr 4454 113 an an DT cord-028721-x6f26ahr 4454 114 unusual unusual JJ cord-028721-x6f26ahr 4454 115 entity entity NN cord-028721-x6f26ahr 4454 116 that that WDT cord-028721-x6f26ahr 4454 117 mimics mimic VBZ cord-028721-x6f26ahr 4454 118 testicular testicular JJ cord-028721-x6f26ahr 4454 119 malignancy malignancy NN cord-028721-x6f26ahr 4455 1 Persistent persistent JJ cord-028721-x6f26ahr 4455 2 erythema erythema NN cord-028721-x6f26ahr 4455 3 and and CC cord-028721-x6f26ahr 4455 4 pruritus pruritus NN cord-028721-x6f26ahr 4455 5 , , , cord-028721-x6f26ahr 4455 6 with with IN cord-028721-x6f26ahr 4455 7 a a DT cord-028721-x6f26ahr 4455 8 confl confl NN cord-028721-x6f26ahr 4455 9 uent uent NN cord-028721-x6f26ahr 4455 10 histiocytic histiocytic NNP cord-028721-x6f26ahr 4455 11 skin skin NN cord-028721-x6f26ahr 4455 12 infi infi NNP cord-028721-x6f26ahr 4455 13 ltrate ltrate NNP cord-028721-x6f26ahr 4455 14 , , , cord-028721-x6f26ahr 4455 15 following follow VBG cord-028721-x6f26ahr 4455 16 the the DT cord-028721-x6f26ahr 4455 17 use use NN cord-028721-x6f26ahr 4455 18 of of IN cord-028721-x6f26ahr 4455 19 a a DT cord-028721-x6f26ahr 4455 20 hydroxyethylstarch hydroxyethylstarch NN cord-028721-x6f26ahr 4455 21 plasma plasma NN cord-028721-x6f26ahr 4455 22 expander expander NN cord-028721-x6f26ahr 4455 23 Epididymitis epididymitis NN cord-028721-x6f26ahr 4455 24 nodosa nodosa RB cord-028721-x6f26ahr 4455 25 . . . cord-028721-x6f26ahr 4456 1 An an DT cord-028721-x6f26ahr 4456 2 epididymal epididymal JJ cord-028721-x6f26ahr 4456 3 lesion lesion NN cord-028721-x6f26ahr 4456 4 analogous analogous JJ cord-028721-x6f26ahr 4456 5 to to IN cord-028721-x6f26ahr 4456 6 vasitis vasitis NNP cord-028721-x6f26ahr 4456 7 nodosa nodosa RB cord-028721-x6f26ahr 4456 8 Amiodarone Amiodarone NNP cord-028721-x6f26ahr 4456 9 in in IN cord-028721-x6f26ahr 4456 10 testis testis NN cord-028721-x6f26ahr 4456 11 and and CC cord-028721-x6f26ahr 4456 12 semen semen NN cord-028721-x6f26ahr 4456 13 Testicular Testicular NNP cord-028721-x6f26ahr 4456 14 dysfunction dysfunction NN cord-028721-x6f26ahr 4456 15 with with IN cord-028721-x6f26ahr 4456 16 amiodarone amiodarone NN cord-028721-x6f26ahr 4456 17 use use NN cord-028721-x6f26ahr 4456 18 Non non JJ cord-028721-x6f26ahr 4456 19 - - JJ cord-028721-x6f26ahr 4456 20 infectious infectious JJ cord-028721-x6f26ahr 4456 21 epididymitis epididymitis NN cord-028721-x6f26ahr 4456 22 associated associate VBN cord-028721-x6f26ahr 4456 23 with with IN cord-028721-x6f26ahr 4456 24 amiodarone amiodarone NN cord-028721-x6f26ahr 4456 25 therapy therapy NN cord-028721-x6f26ahr 4456 26 Amiodaroneinduced Amiodaroneinduced NNP cord-028721-x6f26ahr 4456 27 epididymitis epididymitis NN cord-028721-x6f26ahr 4456 28 : : : cord-028721-x6f26ahr 4456 29 report report NN cord-028721-x6f26ahr 4456 30 of of IN cord-028721-x6f26ahr 4456 31 a a DT cord-028721-x6f26ahr 4456 32 new new JJ cord-028721-x6f26ahr 4456 33 case case NN cord-028721-x6f26ahr 4456 34 and and CC cord-028721-x6f26ahr 4456 35 literature literature NN cord-028721-x6f26ahr 4456 36 review review NN cord-028721-x6f26ahr 4456 37 of of IN cord-028721-x6f26ahr 4456 38 12 12 CD cord-028721-x6f26ahr 4456 39 cases case NNS cord-028721-x6f26ahr 4457 1 Amiodarone Amiodarone NNP cord-028721-x6f26ahr 4457 2 - - HYPH cord-028721-x6f26ahr 4457 3 induced induce VBN cord-028721-x6f26ahr 4457 4 sterile sterile JJ cord-028721-x6f26ahr 4457 5 epididymitis epididymitis NN cord-028721-x6f26ahr 4457 6 Recurrent recurrent JJ cord-028721-x6f26ahr 4457 7 bilateral bilateral JJ cord-028721-x6f26ahr 4458 1 amiodarone amiodarone NN cord-028721-x6f26ahr 4458 2 induced induce VBD cord-028721-x6f26ahr 4458 3 epididymitis epididymitis NNP cord-028721-x6f26ahr 4458 4 Amiodarone Amiodarone NNP cord-028721-x6f26ahr 4458 5 induced induce VBD cord-028721-x6f26ahr 4458 6 epididymitis epididymitis NN cord-028721-x6f26ahr 4458 7 in in IN cord-028721-x6f26ahr 4458 8 children child NNS cord-028721-x6f26ahr 4458 9 Amiodarone Amiodarone NNP cord-028721-x6f26ahr 4458 10 - - HYPH cord-028721-x6f26ahr 4458 11 induced induce VBN cord-028721-x6f26ahr 4458 12 epididymitis epididymitis NN cord-028721-x6f26ahr 4458 13 Granulomatous granulomatous JJ cord-028721-x6f26ahr 4458 14 epididymal epididymal JJ cord-028721-x6f26ahr 4458 15 lesion lesion NN cord-028721-x6f26ahr 4458 16 of of IN cord-028721-x6f26ahr 4458 17 possible possible JJ cord-028721-x6f26ahr 4458 18 ischemic ischemic JJ cord-028721-x6f26ahr 4458 19 origin origin NN cord-028721-x6f26ahr 4459 1 A a DT cord-028721-x6f26ahr 4459 2 stone stone NN cord-028721-x6f26ahr 4459 3 in in IN cord-028721-x6f26ahr 4459 4 the the DT cord-028721-x6f26ahr 4459 5 testicle testicle NN cord-028721-x6f26ahr 4459 6 Testicular Testicular NNP cord-028721-x6f26ahr 4459 7 calculus calculus NN cord-028721-x6f26ahr 4459 8 Orchitis Orchitis NNP cord-028721-x6f26ahr 4459 9 mimicking mimic VBG cord-028721-x6f26ahr 4459 10 testicular testicular JJ cord-028721-x6f26ahr 4459 11 torsion torsion NN cord-028721-x6f26ahr 4459 12 in in IN cord-028721-x6f26ahr 4459 13 Henoch Henoch NNP cord-028721-x6f26ahr 4459 14 - - HYPH cord-028721-x6f26ahr 4459 15 Schönlein Schönlein NNP cord-028721-x6f26ahr 4459 16 's 's POS cord-028721-x6f26ahr 4459 17 purpura purpura NN cord-028721-x6f26ahr 4459 18 Wegener Wegener NNP cord-028721-x6f26ahr 4459 19 's 's POS cord-028721-x6f26ahr 4459 20 granulomatosis granulomatosis NN cord-028721-x6f26ahr 4459 21 involving involve VBG cord-028721-x6f26ahr 4459 22 the the DT cord-028721-x6f26ahr 4459 23 urogenital urogenital JJ cord-028721-x6f26ahr 4459 24 tract tract NN cord-028721-x6f26ahr 4459 25 Testicular Testicular NNP cord-028721-x6f26ahr 4459 26 infarction infarction NN cord-028721-x6f26ahr 4459 27 in in IN cord-028721-x6f26ahr 4459 28 a a DT cord-028721-x6f26ahr 4459 29 12-year 12-year JJ cord-028721-x6f26ahr 4459 30 - - HYPH cord-028721-x6f26ahr 4459 31 old old JJ cord-028721-x6f26ahr 4459 32 boy boy NN cord-028721-x6f26ahr 4459 33 with with IN cord-028721-x6f26ahr 4459 34 Wegener Wegener NNP cord-028721-x6f26ahr 4459 35 's 's POS cord-028721-x6f26ahr 4459 36 granulomatosis granulomatosis NN cord-028721-x6f26ahr 4459 37 Cogan Cogan NNP cord-028721-x6f26ahr 4459 38 's 's POS cord-028721-x6f26ahr 4459 39 syndrome syndrome NN cord-028721-x6f26ahr 4459 40 : : : cord-028721-x6f26ahr 4459 41 18 18 CD cord-028721-x6f26ahr 4459 42 cases case NNS cord-028721-x6f26ahr 4459 43 and and CC cord-028721-x6f26ahr 4459 44 a a DT cord-028721-x6f26ahr 4459 45 review review NN cord-028721-x6f26ahr 4459 46 of of IN cord-028721-x6f26ahr 4459 47 the the DT cord-028721-x6f26ahr 4459 48 literature literature NN cord-028721-x6f26ahr 4460 1 Recurrent recurrent JJ cord-028721-x6f26ahr 4460 2 epididymo epididymo NN cord-028721-x6f26ahr 4460 3 - - HYPH cord-028721-x6f26ahr 4460 4 orchitis orchitis NN cord-028721-x6f26ahr 4460 5 in in IN cord-028721-x6f26ahr 4460 6 patients patient NNS cord-028721-x6f26ahr 4460 7 with with IN cord-028721-x6f26ahr 4460 8 Behçet Behçet NNP cord-028721-x6f26ahr 4460 9 's 's POS cord-028721-x6f26ahr 4460 10 disease disease NN cord-028721-x6f26ahr 4460 11 Isolated isolate VBN cord-028721-x6f26ahr 4460 12 polyarteritis polyarteritis NN cord-028721-x6f26ahr 4460 13 nodosa nodosa RB cord-028721-x6f26ahr 4460 14 of of IN cord-028721-x6f26ahr 4460 15 the the DT cord-028721-x6f26ahr 4460 16 male male JJ cord-028721-x6f26ahr 4460 17 reproductive reproductive JJ cord-028721-x6f26ahr 4460 18 system system NN cord-028721-x6f26ahr 4460 19 Testicular Testicular NNP cord-028721-x6f26ahr 4460 20 mass mass NN cord-028721-x6f26ahr 4460 21 as as IN cord-028721-x6f26ahr 4460 22 presenting present VBG cord-028721-x6f26ahr 4460 23 symptom symptom NN cord-028721-x6f26ahr 4460 24 of of IN cord-028721-x6f26ahr 4460 25 isolated isolated JJ cord-028721-x6f26ahr 4460 26 polyarteritis polyarteritis NN cord-028721-x6f26ahr 4460 27 nodosa nodosa NNP cord-028721-x6f26ahr 4460 28 Testicular testicular JJ cord-028721-x6f26ahr 4460 29 lesions lesion NNS cord-028721-x6f26ahr 4460 30 of of IN cord-028721-x6f26ahr 4460 31 periarteritis periarteritis NNP cord-028721-x6f26ahr 4460 32 nodosa nodosa NNP cord-028721-x6f26ahr 4460 33 , , , cord-028721-x6f26ahr 4460 34 with with IN cord-028721-x6f26ahr 4460 35 special special JJ cord-028721-x6f26ahr 4460 36 reference reference NN cord-028721-x6f26ahr 4460 37 to to IN cord-028721-x6f26ahr 4460 38 diagnosis diagnosis NN cord-028721-x6f26ahr 4461 1 Polyarteritis Polyarteritis NNP cord-028721-x6f26ahr 4461 2 nodosa nodosa RB cord-028721-x6f26ahr 4461 3 presenting present VBG cord-028721-x6f26ahr 4461 4 as as IN cord-028721-x6f26ahr 4461 5 acute acute JJ cord-028721-x6f26ahr 4461 6 orchitis orchitis NN cord-028721-x6f26ahr 4461 7 : : : cord-028721-x6f26ahr 4462 1 A a DT cord-028721-x6f26ahr 4462 2 case case NN cord-028721-x6f26ahr 4462 3 report report NN cord-028721-x6f26ahr 4462 4 and and CC cord-028721-x6f26ahr 4462 5 review review NN cord-028721-x6f26ahr 4462 6 of of IN cord-028721-x6f26ahr 4462 7 the the DT cord-028721-x6f26ahr 4462 8 literature literature NN cord-028721-x6f26ahr 4462 9 Isolated isolate VBN cord-028721-x6f26ahr 4462 10 epididymal epididymal JJ cord-028721-x6f26ahr 4462 11 vasculitis vasculitis NN cord-028721-x6f26ahr 4462 12 Limited limited JJ cord-028721-x6f26ahr 4462 13 polyarteritis polyarteritis NN cord-028721-x6f26ahr 4462 14 nodosa nodosa RB cord-028721-x6f26ahr 4462 15 of of IN cord-028721-x6f26ahr 4462 16 the the DT cord-028721-x6f26ahr 4462 17 male male JJ cord-028721-x6f26ahr 4462 18 and and CC cord-028721-x6f26ahr 4462 19 female female JJ cord-028721-x6f26ahr 4462 20 reproductive reproductive JJ cord-028721-x6f26ahr 4462 21 systems system NNS cord-028721-x6f26ahr 4462 22 : : : cord-028721-x6f26ahr 4462 23 diagnostic diagnostic JJ cord-028721-x6f26ahr 4462 24 and and CC cord-028721-x6f26ahr 4462 25 therapeutic therapeutic JJ cord-028721-x6f26ahr 4462 26 approach approach NN cord-028721-x6f26ahr 4463 1 Polyarteritis polyarteritis NN cord-028721-x6f26ahr 4463 2 nodosa nodosa RB cord-028721-x6f26ahr 4463 3 masquerading masquerade VBG cord-028721-x6f26ahr 4463 4 as as IN cord-028721-x6f26ahr 4463 5 a a DT cord-028721-x6f26ahr 4463 6 primary primary JJ cord-028721-x6f26ahr 4463 7 testicular testicular NN cord-028721-x6f26ahr 4463 8 neoplasm neoplasm NN cord-028721-x6f26ahr 4463 9 . . . cord-028721-x6f26ahr 4464 1 A a DT cord-028721-x6f26ahr 4464 2 case case NN cord-028721-x6f26ahr 4464 3 report report NN cord-028721-x6f26ahr 4464 4 and and CC cord-028721-x6f26ahr 4464 5 review review NN cord-028721-x6f26ahr 4464 6 of of IN cord-028721-x6f26ahr 4464 7 the the DT cord-028721-x6f26ahr 4464 8 literature literature NN cord-028721-x6f26ahr 4464 9 Testicular Testicular NNP cord-028721-x6f26ahr 4464 10 vasculitis vasculitis NN cord-028721-x6f26ahr 4464 11 : : : cord-028721-x6f26ahr 4464 12 Implication implication NN cord-028721-x6f26ahr 4464 13 for for IN cord-028721-x6f26ahr 4464 14 systemic systemic JJ cord-028721-x6f26ahr 4464 15 disease disease NN cord-028721-x6f26ahr 4464 16 Torsión Torsión NNP cord-028721-x6f26ahr 4464 17 del del NNP cord-028721-x6f26ahr 4464 18 cordón cordón NNP cord-028721-x6f26ahr 4464 19 espermático espermático NNP cord-028721-x6f26ahr 4464 20 . . . cord-028721-x6f26ahr 4465 1 A a DT cord-028721-x6f26ahr 4465 2 propósito propósito FW cord-028721-x6f26ahr 4465 3 de de NNP cord-028721-x6f26ahr 4465 4 87 87 CD cord-028721-x6f26ahr 4465 5 nuevos nuevos NNP cord-028721-x6f26ahr 4465 6 casos caso NNS cord-028721-x6f26ahr 4465 7 . . . cord-028721-x6f26ahr 4466 1 Revisión Revisión NNP cord-028721-x6f26ahr 4466 2 de de NNP cord-028721-x6f26ahr 4466 3 la la NNP cord-028721-x6f26ahr 4466 4 literatura literatura NNP cord-028721-x6f26ahr 4466 5 Controversies Controversies NNPS cord-028721-x6f26ahr 4466 6 of of IN cord-028721-x6f26ahr 4466 7 perinatal perinatal JJ cord-028721-x6f26ahr 4466 8 torsion torsion NN cord-028721-x6f26ahr 4466 9 of of IN cord-028721-x6f26ahr 4466 10 the the DT cord-028721-x6f26ahr 4466 11 spermatic spermatic JJ cord-028721-x6f26ahr 4466 12 cord cord NN cord-028721-x6f26ahr 4466 13 : : : cord-028721-x6f26ahr 4466 14 a a DT cord-028721-x6f26ahr 4466 15 review review NN cord-028721-x6f26ahr 4466 16 , , , cord-028721-x6f26ahr 4466 17 survey survey NN cord-028721-x6f26ahr 4466 18 and and CC cord-028721-x6f26ahr 4466 19 recommendations recommendation NNS cord-028721-x6f26ahr 4466 20 Prenatal prenatal JJ cord-028721-x6f26ahr 4466 21 testicular testicular JJ cord-028721-x6f26ahr 4466 22 torsion torsion NN cord-028721-x6f26ahr 4466 23 : : : cord-028721-x6f26ahr 4466 24 ultrasonographic ultrasonographic JJ cord-028721-x6f26ahr 4466 25 features feature NNS cord-028721-x6f26ahr 4466 26 , , , cord-028721-x6f26ahr 4466 27 management management NN cord-028721-x6f26ahr 4466 28 and and CC cord-028721-x6f26ahr 4466 29 histopathological histopathological NNP cord-028721-x6f26ahr 4466 30 fi fi NNP cord-028721-x6f26ahr 4466 31 ndings nding NNS cord-028721-x6f26ahr 4466 32 Torsion Torsion NNP cord-028721-x6f26ahr 4466 33 of of IN cord-028721-x6f26ahr 4466 34 the the DT cord-028721-x6f26ahr 4466 35 testis testis NN cord-028721-x6f26ahr 4466 36 Testicular testicular JJ cord-028721-x6f26ahr 4466 37 torsion torsion NN cord-028721-x6f26ahr 4466 38 in in IN cord-028721-x6f26ahr 4466 39 a a DT cord-028721-x6f26ahr 4466 40 68-year 68-year JJ cord-028721-x6f26ahr 4466 41 - - HYPH cord-028721-x6f26ahr 4466 42 old old JJ cord-028721-x6f26ahr 4466 43 man man NN cord-028721-x6f26ahr 4466 44 Testicular Testicular NNP cord-028721-x6f26ahr 4466 45 torsion torsion NN cord-028721-x6f26ahr 4466 46 : : : cord-028721-x6f26ahr 4466 47 simple simple JJ cord-028721-x6f26ahr 4466 48 grading grading NN cord-028721-x6f26ahr 4466 49 for for IN cord-028721-x6f26ahr 4466 50 histological histological JJ cord-028721-x6f26ahr 4466 51 evaluation evaluation NN cord-028721-x6f26ahr 4466 52 of of IN cord-028721-x6f26ahr 4466 53 tissues tissue NNS cord-028721-x6f26ahr 4466 54 damage damage VB cord-028721-x6f26ahr 4466 55 Primary primary JJ cord-028721-x6f26ahr 4466 56 testicular testicular JJ cord-028721-x6f26ahr 4466 57 lesions lesion NNS cord-028721-x6f26ahr 4466 58 in in IN cord-028721-x6f26ahr 4466 59 the the DT cord-028721-x6f26ahr 4466 60 twisted twisted JJ cord-028721-x6f26ahr 4466 61 testis testis NN cord-028721-x6f26ahr 4466 62 Torsión Torsión NNP cord-028721-x6f26ahr 4466 63 testicular testicular NN cord-028721-x6f26ahr 4466 64 antes antes NNP cord-028721-x6f26ahr 4466 65 de de NNP cord-028721-x6f26ahr 4466 66 6 6 CD cord-028721-x6f26ahr 4466 67 horas horas NNP cord-028721-x6f26ahr 4467 1 Late late JJ cord-028721-x6f26ahr 4467 2 postoperative postoperative JJ cord-028721-x6f26ahr 4467 3 results result NNS cord-028721-x6f26ahr 4467 4 in in IN cord-028721-x6f26ahr 4467 5 males male NNS cord-028721-x6f26ahr 4467 6 treated treat VBN cord-028721-x6f26ahr 4467 7 for for IN cord-028721-x6f26ahr 4467 8 testicular testicular JJ cord-028721-x6f26ahr 4467 9 torsion torsion NN cord-028721-x6f26ahr 4467 10 during during IN cord-028721-x6f26ahr 4467 11 childhood childhood NN cord-028721-x6f26ahr 4467 12 Testicular Testicular NNP cord-028721-x6f26ahr 4467 13 tissue tissue NN cord-028721-x6f26ahr 4467 14 bleeding bleed VBG cord-028721-x6f26ahr 4467 15 as as IN cord-028721-x6f26ahr 4467 16 an an DT cord-028721-x6f26ahr 4467 17 indicator indicator NN cord-028721-x6f26ahr 4467 18 of of IN cord-028721-x6f26ahr 4467 19 gonadal gonadal JJ cord-028721-x6f26ahr 4467 20 salvageability salvageability NN cord-028721-x6f26ahr 4467 21 in in IN cord-028721-x6f26ahr 4467 22 testicular testicular JJ cord-028721-x6f26ahr 4467 23 torsion torsion NN cord-028721-x6f26ahr 4467 24 surgery surgery NN cord-028721-x6f26ahr 4468 1 Intermittent intermittent JJ cord-028721-x6f26ahr 4468 2 testicular testicular JJ cord-028721-x6f26ahr 4468 3 torsion torsion NN cord-028721-x6f26ahr 4469 1 Lipomembranous lipomembranous JJ cord-028721-x6f26ahr 4469 2 fat fat JJ cord-028721-x6f26ahr 4469 3 necrosis necrosis NN cord-028721-x6f26ahr 4469 4 in in IN cord-028721-x6f26ahr 4469 5 three three CD cord-028721-x6f26ahr 4469 6 cases case NNS cord-028721-x6f26ahr 4469 7 of of IN cord-028721-x6f26ahr 4469 8 testicular testicular JJ cord-028721-x6f26ahr 4469 9 torsion torsion NN cord-028721-x6f26ahr 4469 10 Immunologic immunologic JJ cord-028721-x6f26ahr 4469 11 aspects aspect NNS cord-028721-x6f26ahr 4469 12 of of IN cord-028721-x6f26ahr 4469 13 testicular testicular JJ cord-028721-x6f26ahr 4469 14 torsion torsion NN cord-028721-x6f26ahr 4469 15 : : : cord-028721-x6f26ahr 4469 16 detection detection NN cord-028721-x6f26ahr 4469 17 of of IN cord-028721-x6f26ahr 4469 18 antisperm antisperm NNP cord-028721-x6f26ahr 4469 19 antibodies antibody NNS cord-028721-x6f26ahr 4469 20 in in IN cord-028721-x6f26ahr 4469 21 contralateral contralateral JJ cord-028721-x6f26ahr 4469 22 testicle testicle NN cord-028721-x6f26ahr 4469 23 Ipsilateral Ipsilateral NNP cord-028721-x6f26ahr 4469 24 and and CC cord-028721-x6f26ahr 4469 25 contralateral contralateral JJ cord-028721-x6f26ahr 4469 26 testicular testicular JJ cord-028721-x6f26ahr 4469 27 biochemical biochemical JJ cord-028721-x6f26ahr 4469 28 acute acute JJ cord-028721-x6f26ahr 4469 29 changes change NNS cord-028721-x6f26ahr 4469 30 after after IN cord-028721-x6f26ahr 4469 31 unilateral unilateral JJ cord-028721-x6f26ahr 4469 32 testicular testicular JJ cord-028721-x6f26ahr 4469 33 torsion torsion NN cord-028721-x6f26ahr 4469 34 and and CC cord-028721-x6f26ahr 4469 35 detorsion detorsion NN cord-028721-x6f26ahr 4469 36 Increased increase VBN cord-028721-x6f26ahr 4469 37 apoptosis apoptosis NN cord-028721-x6f26ahr 4469 38 in in IN cord-028721-x6f26ahr 4469 39 the the DT cord-028721-x6f26ahr 4469 40 contralateral contralateral JJ cord-028721-x6f26ahr 4469 41 testes testis NNS cord-028721-x6f26ahr 4469 42 of of IN cord-028721-x6f26ahr 4469 43 patients patient NNS cord-028721-x6f26ahr 4469 44 with with IN cord-028721-x6f26ahr 4469 45 testicular testicular JJ cord-028721-x6f26ahr 4469 46 torsion torsion NN cord-028721-x6f26ahr 4469 47 as as IN cord-028721-x6f26ahr 4469 48 a a DT cord-028721-x6f26ahr 4469 49 factor factor NN cord-028721-x6f26ahr 4469 50 for for IN cord-028721-x6f26ahr 4469 51 infertility infertility NN cord-028721-x6f26ahr 4469 52 Unilateral unilateral JJ cord-028721-x6f26ahr 4469 53 testicular testicular JJ cord-028721-x6f26ahr 4469 54 torsion torsion NN cord-028721-x6f26ahr 4469 55 : : : cord-028721-x6f26ahr 4470 1 abnormal abnormal JJ cord-028721-x6f26ahr 4470 2 histological histological JJ cord-028721-x6f26ahr 4470 3 fi fi NN cord-028721-x6f26ahr 4470 4 ndings nding NNS cord-028721-x6f26ahr 4470 5 in in IN cord-028721-x6f26ahr 4470 6 the the DT cord-028721-x6f26ahr 4470 7 contralateral contralateral JJ cord-028721-x6f26ahr 4470 8 testis testis NN cord-028721-x6f26ahr 4470 9 . . . cord-028721-x6f26ahr 4471 1 Cause cause VB cord-028721-x6f26ahr 4471 2 or or CC cord-028721-x6f26ahr 4471 3 effect effect NN cord-028721-x6f26ahr 4471 4 ? ? . cord-028721-x6f26ahr 4472 1 Testicular testicular JJ cord-028721-x6f26ahr 4472 2 injury injury NN cord-028721-x6f26ahr 4472 3 . . . cord-028721-x6f26ahr 4473 1 Late late JJ cord-028721-x6f26ahr 4473 2 results result NNS cord-028721-x6f26ahr 4473 3 of of IN cord-028721-x6f26ahr 4473 4 semen semen NN cord-028721-x6f26ahr 4473 5 analyses analysis NNS cord-028721-x6f26ahr 4473 6 after after IN cord-028721-x6f26ahr 4473 7 orchiectomy orchiectomy NN cord-028721-x6f26ahr 4473 8 Testicular testicular JJ cord-028721-x6f26ahr 4473 9 atrophy atrophy NN cord-028721-x6f26ahr 4473 10 as as IN cord-028721-x6f26ahr 4473 11 a a DT cord-028721-x6f26ahr 4473 12 sequela sequela NN cord-028721-x6f26ahr 4473 13 of of IN cord-028721-x6f26ahr 4473 14 inguinal inguinal JJ cord-028721-x6f26ahr 4473 15 hernioplasty hernioplasty NNP cord-028721-x6f26ahr 4473 16 Cooper Cooper NNP cord-028721-x6f26ahr 4473 17 's 's POS cord-028721-x6f26ahr 4473 18 ligament ligament NN cord-028721-x6f26ahr 4473 19 repair repair NN cord-028721-x6f26ahr 4473 20 for for IN cord-028721-x6f26ahr 4473 21 adult adult NN cord-028721-x6f26ahr 4473 22 growing grow VBG cord-028721-x6f26ahr 4473 23 hernias hernia NNS cord-028721-x6f26ahr 4473 24 Spontaneous spontaneous JJ cord-028721-x6f26ahr 4473 25 thrombosis thrombosis NN cord-028721-x6f26ahr 4473 26 of of IN cord-028721-x6f26ahr 4473 27 left left JJ cord-028721-x6f26ahr 4473 28 spermatic spermatic JJ cord-028721-x6f26ahr 4473 29 vein vein NN cord-028721-x6f26ahr 4473 30 : : : cord-028721-x6f26ahr 4473 31 Report report NN cord-028721-x6f26ahr 4473 32 of of IN cord-028721-x6f26ahr 4473 33 2 2 CD cord-028721-x6f26ahr 4473 34 cases case NNS cord-028721-x6f26ahr 4473 35 Postsurgical Postsurgical NNP cord-028721-x6f26ahr 4473 36 focal focal JJ cord-028721-x6f26ahr 4473 37 testicular testicular NN cord-028721-x6f26ahr 4473 38 infarct infarct NN cord-028721-x6f26ahr 4473 39 Localised localised JJ cord-028721-x6f26ahr 4473 40 infarction infarction NN cord-028721-x6f26ahr 4473 41 of of IN cord-028721-x6f26ahr 4473 42 the the DT cord-028721-x6f26ahr 4473 43 testis testis NN cord-028721-x6f26ahr 4473 44 Acute acute JJ cord-028721-x6f26ahr 4473 45 segmental segmental JJ cord-028721-x6f26ahr 4473 46 testicular testicular JJ cord-028721-x6f26ahr 4473 47 infarction infarction NN cord-028721-x6f26ahr 4473 48 : : : cord-028721-x6f26ahr 4473 49 differentiation differentiation NN cord-028721-x6f26ahr 4473 50 from from IN cord-028721-x6f26ahr 4473 51 tumour tumour NN cord-028721-x6f26ahr 4473 52 using use VBG cord-028721-x6f26ahr 4473 53 high high JJ cord-028721-x6f26ahr 4473 54 frequency frequency NN cord-028721-x6f26ahr 4473 55 colour colour NN cord-028721-x6f26ahr 4473 56 Doppler doppler NN cord-028721-x6f26ahr 4473 57 ultrasound ultrasound NN cord-028721-x6f26ahr 4473 58 Observations observation NNS cord-028721-x6f26ahr 4473 59 on on IN cord-028721-x6f26ahr 4473 60 the the DT cord-028721-x6f26ahr 4473 61 structure structure NN cord-028721-x6f26ahr 4473 62 and and CC cord-028721-x6f26ahr 4473 63 diseases disease NNS cord-028721-x6f26ahr 4473 64 of of IN cord-028721-x6f26ahr 4473 65 the the DT cord-028721-x6f26ahr 4473 66 testis testis NN cord-028721-x6f26ahr 4473 67 Cysts cyst NNS cord-028721-x6f26ahr 4473 68 of of IN cord-028721-x6f26ahr 4473 69 the the DT cord-028721-x6f26ahr 4473 70 testicle testicle NN cord-028721-x6f26ahr 4473 71 Tunica Tunica NNP cord-028721-x6f26ahr 4473 72 albuginea albuginea NNP cord-028721-x6f26ahr 4473 73 cyst cyst NN cord-028721-x6f26ahr 4473 74 : : : cord-028721-x6f26ahr 4473 75 rare rare JJ cord-028721-x6f26ahr 4473 76 testicular testicular JJ cord-028721-x6f26ahr 4473 77 mass mass NN cord-028721-x6f26ahr 4473 78 High high JJ cord-028721-x6f26ahr 4473 79 - - HYPH cord-028721-x6f26ahr 4473 80 resolution resolution NN cord-028721-x6f26ahr 4473 81 sonography sonography NN cord-028721-x6f26ahr 4473 82 of of IN cord-028721-x6f26ahr 4473 83 scrotal scrotal JJ cord-028721-x6f26ahr 4473 84 contents content NNS cord-028721-x6f26ahr 4473 85 in in IN cord-028721-x6f26ahr 4473 86 asymptomatic asymptomatic JJ cord-028721-x6f26ahr 4473 87 subjects subject NNS cord-028721-x6f26ahr 4474 1 The the DT cord-028721-x6f26ahr 4474 2 high high JJ cord-028721-x6f26ahr 4474 3 incidence incidence NN cord-028721-x6f26ahr 4474 4 of of IN cord-028721-x6f26ahr 4474 5 benign benign JJ cord-028721-x6f26ahr 4474 6 testicular testicular JJ cord-028721-x6f26ahr 4474 7 tumors tumor NNS cord-028721-x6f26ahr 4475 1 Testicular testicular JJ cord-028721-x6f26ahr 4475 2 cysts cyst NNS cord-028721-x6f26ahr 4475 3 . . . cord-028721-x6f26ahr 4476 1 US US NNP cord-028721-x6f26ahr 4476 2 fi fi NNP cord-028721-x6f26ahr 4476 3 ndings nding NNS cord-028721-x6f26ahr 4477 1 Benign benign JJ cord-028721-x6f26ahr 4477 2 intrascrotal intrascrotal JJ cord-028721-x6f26ahr 4477 3 lesions lesion NNS cord-028721-x6f26ahr 4478 1 Sonography sonography NN cord-028721-x6f26ahr 4478 2 of of IN cord-028721-x6f26ahr 4478 3 benign benign JJ cord-028721-x6f26ahr 4478 4 intrascrotal intrascrotal JJ cord-028721-x6f26ahr 4478 5 lesions lesion NNS cord-028721-x6f26ahr 4478 6 Cysts cyst NNS cord-028721-x6f26ahr 4478 7 of of IN cord-028721-x6f26ahr 4478 8 the the DT cord-028721-x6f26ahr 4478 9 testicular testicular JJ cord-028721-x6f26ahr 4478 10 parenchyma parenchyma NN cord-028721-x6f26ahr 4478 11 and and CC cord-028721-x6f26ahr 4478 12 tunica tunica NNP cord-028721-x6f26ahr 4478 13 albuginea albuginea NN cord-028721-x6f26ahr 4478 14 Efferent Efferent NNP cord-028721-x6f26ahr 4478 15 ductule ductule NNP cord-028721-x6f26ahr 4478 16 cyst cyst NN cord-028721-x6f26ahr 4478 17 of of IN cord-028721-x6f26ahr 4478 18 tunica tunica NNP cord-028721-x6f26ahr 4478 19 albuginea albuginea NNP cord-028721-x6f26ahr 4478 20 Simple Simple NNP cord-028721-x6f26ahr 4478 21 cyst cyst NN cord-028721-x6f26ahr 4478 22 of of IN cord-028721-x6f26ahr 4478 23 the the DT cord-028721-x6f26ahr 4478 24 rete rete NN cord-028721-x6f26ahr 4478 25 testis testis NN cord-028721-x6f26ahr 4478 26 Intratesticular Intratesticular NNP cord-028721-x6f26ahr 4478 27 spermatocele spermatocele NNP cord-028721-x6f26ahr 4479 1 Simple simple JJ cord-028721-x6f26ahr 4479 2 cyst cyst NN cord-028721-x6f26ahr 4479 3 of of IN cord-028721-x6f26ahr 4479 4 the the DT cord-028721-x6f26ahr 4479 5 testis testis NN cord-028721-x6f26ahr 4479 6 : : : cord-028721-x6f26ahr 4480 1 case case NNP cord-028721-x6f26ahr 4480 2 report report NN cord-028721-x6f26ahr 4480 3 and and CC cord-028721-x6f26ahr 4480 4 review review NN cord-028721-x6f26ahr 4480 5 of of IN cord-028721-x6f26ahr 4480 6 literature literature NN cord-028721-x6f26ahr 4481 1 Congenital congenital JJ cord-028721-x6f26ahr 4481 2 simple simple JJ cord-028721-x6f26ahr 4481 3 cysts cyst NNS cord-028721-x6f26ahr 4481 4 of of IN cord-028721-x6f26ahr 4481 5 the the DT cord-028721-x6f26ahr 4481 6 testis testis NN cord-028721-x6f26ahr 4481 7 : : : cord-028721-x6f26ahr 4481 8 a a DT cord-028721-x6f26ahr 4481 9 hitherto hitherto RB cord-028721-x6f26ahr 4481 10 undescribed undescribed JJ cord-028721-x6f26ahr 4481 11 lesion lesion NN cord-028721-x6f26ahr 4481 12 Intratesticular Intratesticular NNP cord-028721-x6f26ahr 4481 13 cysts cyst NNS cord-028721-x6f26ahr 4482 1 Testicular testicular JJ cord-028721-x6f26ahr 4482 2 cysts cyst NNS cord-028721-x6f26ahr 4482 3 : : : cord-028721-x6f26ahr 4483 1 Differentiation differentiation NN cord-028721-x6f26ahr 4483 2 with with IN cord-028721-x6f26ahr 4483 3 US US NNP cord-028721-x6f26ahr 4483 4 and and CC cord-028721-x6f26ahr 4483 5 clinical clinical JJ cord-028721-x6f26ahr 4483 6 fi fi NN cord-028721-x6f26ahr 4483 7 ndings nding NNS cord-028721-x6f26ahr 4484 1 Simple simple JJ cord-028721-x6f26ahr 4484 2 testicular testicular JJ cord-028721-x6f26ahr 4484 3 cyst cyst NN cord-028721-x6f26ahr 4484 4 : : : cord-028721-x6f26ahr 4485 1 A a DT cord-028721-x6f26ahr 4485 2 rare rare JJ cord-028721-x6f26ahr 4485 3 cause cause NN cord-028721-x6f26ahr 4485 4 of of IN cord-028721-x6f26ahr 4485 5 scrotal scrotal JJ cord-028721-x6f26ahr 4485 6 swelling swelling NN cord-028721-x6f26ahr 4485 7 in in IN cord-028721-x6f26ahr 4485 8 infancy infancy JJ cord-028721-x6f26ahr 4485 9 Bilateral bilateral JJ cord-028721-x6f26ahr 4485 10 intratesticular intratesticular JJ cord-028721-x6f26ahr 4485 11 cysts cyst NNS cord-028721-x6f26ahr 4485 12 . . . cord-028721-x6f26ahr 4486 1 A a DT cord-028721-x6f26ahr 4486 2 specifi specifi NN cord-028721-x6f26ahr 4486 3 c c NN cord-028721-x6f26ahr 4486 4 entity entity NN cord-028721-x6f26ahr 4486 5 Cysts Cysts NNPS cord-028721-x6f26ahr 4486 6 of of IN cord-028721-x6f26ahr 4486 7 the the DT cord-028721-x6f26ahr 4486 8 tunica tunica NNP cord-028721-x6f26ahr 4486 9 albuginea albuginea NNP cord-028721-x6f26ahr 4486 10 ( ( -LRB- cord-028721-x6f26ahr 4486 11 cysts cyst NNS cord-028721-x6f26ahr 4486 12 of of IN cord-028721-x6f26ahr 4486 13 the the DT cord-028721-x6f26ahr 4486 14 testis testis NN cord-028721-x6f26ahr 4486 15 ) ) -RRB- cord-028721-x6f26ahr 4486 16 Cysts cyst NNS cord-028721-x6f26ahr 4486 17 of of IN cord-028721-x6f26ahr 4486 18 the the DT cord-028721-x6f26ahr 4486 19 tunica tunica NNP cord-028721-x6f26ahr 4486 20 albuginea albuginea NNP cord-028721-x6f26ahr 4486 21 testis testis NN cord-028721-x6f26ahr 4486 22 Nonneoplastic nonneoplastic JJ cord-028721-x6f26ahr 4486 23 cystic cystic JJ cord-028721-x6f26ahr 4486 24 lesions lesion NNS cord-028721-x6f26ahr 4486 25 of of IN cord-028721-x6f26ahr 4486 26 the the DT cord-028721-x6f26ahr 4486 27 tunica tunica NNP cord-028721-x6f26ahr 4486 28 albuginea albuginea NNP cord-028721-x6f26ahr 4486 29 : : : cord-028721-x6f26ahr 4486 30 an an DT cord-028721-x6f26ahr 4486 31 electron electron NN cord-028721-x6f26ahr 4486 32 microscopic microscopic JJ cord-028721-x6f26ahr 4486 33 and and CC cord-028721-x6f26ahr 4486 34 clinical clinical JJ cord-028721-x6f26ahr 4486 35 study study NN cord-028721-x6f26ahr 4486 36 of of IN cord-028721-x6f26ahr 4486 37 2 2 CD cord-028721-x6f26ahr 4486 38 cases case NNS cord-028721-x6f26ahr 4486 39 Cysts cyst NNS cord-028721-x6f26ahr 4486 40 of of IN cord-028721-x6f26ahr 4486 41 the the DT cord-028721-x6f26ahr 4486 42 tunica tunica NNP cord-028721-x6f26ahr 4486 43 albuginea albuginea NNP cord-028721-x6f26ahr 4486 44 : : : cord-028721-x6f26ahr 4486 45 report report NN cord-028721-x6f26ahr 4486 46 of of IN cord-028721-x6f26ahr 4486 47 4 4 CD cord-028721-x6f26ahr 4486 48 cases case NNS cord-028721-x6f26ahr 4486 49 and and CC cord-028721-x6f26ahr 4486 50 review review NN cord-028721-x6f26ahr 4486 51 of of IN cord-028721-x6f26ahr 4486 52 the the DT cord-028721-x6f26ahr 4486 53 literature literature NN cord-028721-x6f26ahr 4486 54 Cysts cyst NNS cord-028721-x6f26ahr 4486 55 of of IN cord-028721-x6f26ahr 4486 56 the the DT cord-028721-x6f26ahr 4486 57 tunica tunica NNP cord-028721-x6f26ahr 4486 58 albuginea albuginea NNP cord-028721-x6f26ahr 4486 59 : : : cord-028721-x6f26ahr 4486 60 a a DT cord-028721-x6f26ahr 4486 61 report report NN cord-028721-x6f26ahr 4486 62 of of IN cord-028721-x6f26ahr 4486 63 3 3 CD cord-028721-x6f26ahr 4486 64 cases case NNS cord-028721-x6f26ahr 4486 65 with with IN cord-028721-x6f26ahr 4486 66 a a DT cord-028721-x6f26ahr 4486 67 review review NN cord-028721-x6f26ahr 4486 68 of of IN cord-028721-x6f26ahr 4486 69 the the DT cord-028721-x6f26ahr 4486 70 literature literature NN cord-028721-x6f26ahr 4486 71 High high JJ cord-028721-x6f26ahr 4486 72 resolution resolution NN cord-028721-x6f26ahr 4486 73 ultrasonography ultrasonography NN cord-028721-x6f26ahr 4486 74 in in IN cord-028721-x6f26ahr 4486 75 the the DT cord-028721-x6f26ahr 4486 76 diagnosis diagnosis NN cord-028721-x6f26ahr 4486 77 of of IN cord-028721-x6f26ahr 4486 78 simple simple JJ cord-028721-x6f26ahr 4486 79 intratesticular intratesticular JJ cord-028721-x6f26ahr 4486 80 cysts cyst NNS cord-028721-x6f26ahr 4486 81 Simple Simple NNP cord-028721-x6f26ahr 4486 82 testicular testicular JJ cord-028721-x6f26ahr 4486 83 cyst cyst NN cord-028721-x6f26ahr 4486 84 diagnosed diagnose VBN cord-028721-x6f26ahr 4486 85 preoperatively preoperatively NN cord-028721-x6f26ahr 4486 86 by by IN cord-028721-x6f26ahr 4486 87 ultrasound ultrasound NN cord-028721-x6f26ahr 4486 88 Surveillance surveillance NN cord-028721-x6f26ahr 4486 89 strategy strategy NN cord-028721-x6f26ahr 4486 90 for for IN cord-028721-x6f26ahr 4486 91 intratesticular intratesticular NNP cord-028721-x6f26ahr 4486 92 cysts cyst NNS cord-028721-x6f26ahr 4486 93 : : : cord-028721-x6f26ahr 4486 94 preliminary preliminary JJ cord-028721-x6f26ahr 4486 95 report report NN cord-028721-x6f26ahr 4487 1 Simple simple JJ cord-028721-x6f26ahr 4487 2 cysts cyst NNS cord-028721-x6f26ahr 4487 3 of of IN cord-028721-x6f26ahr 4487 4 the the DT cord-028721-x6f26ahr 4487 5 testis testis NN cord-028721-x6f26ahr 4487 6 in in IN cord-028721-x6f26ahr 4487 7 children child NNS cord-028721-x6f26ahr 4487 8 : : : cord-028721-x6f26ahr 4488 1 Preoperative preoperative JJ cord-028721-x6f26ahr 4488 2 diagnosis diagnosis NN cord-028721-x6f26ahr 4488 3 by by IN cord-028721-x6f26ahr 4488 4 ultrasound ultrasound NN cord-028721-x6f26ahr 4488 5 and and CC cord-028721-x6f26ahr 4488 6 excision excision NN cord-028721-x6f26ahr 4488 7 with with IN cord-028721-x6f26ahr 4488 8 testicular testicular JJ cord-028721-x6f26ahr 4488 9 preservation preservation NN cord-028721-x6f26ahr 4488 10 Rete Rete NNP cord-028721-x6f26ahr 4488 11 testis testis NN cord-028721-x6f26ahr 4488 12 dysgenesis dysgenesis NN cord-028721-x6f26ahr 4488 13 . . . cord-028721-x6f26ahr 4489 1 A a DT cord-028721-x6f26ahr 4489 2 characteristic characteristic JJ cord-028721-x6f26ahr 4489 3 lesion lesion NN cord-028721-x6f26ahr 4489 4 of of IN cord-028721-x6f26ahr 4489 5 undescended undescended JJ cord-028721-x6f26ahr 4489 6 testes testis NNS cord-028721-x6f26ahr 4489 7 Estrogen Estrogen NNP cord-028721-x6f26ahr 4489 8 receptor receptor NN cord-028721-x6f26ahr 4489 9 alpha alpha NN cord-028721-x6f26ahr 4489 10 has have VBZ cord-028721-x6f26ahr 4489 11 a a DT cord-028721-x6f26ahr 4489 12 functional functional JJ cord-028721-x6f26ahr 4489 13 role role NN cord-028721-x6f26ahr 4489 14 in in IN cord-028721-x6f26ahr 4489 15 the the DT cord-028721-x6f26ahr 4489 16 mouse mouse NN cord-028721-x6f26ahr 4489 17 rete rete NNP cord-028721-x6f26ahr 4489 18 testis testis NN cord-028721-x6f26ahr 4489 19 and and CC cord-028721-x6f26ahr 4489 20 efferent efferent JJ cord-028721-x6f26ahr 4489 21 ductules ductule NNS cord-028721-x6f26ahr 4489 22 Cystic cystic JJ cord-028721-x6f26ahr 4489 23 transformation transformation NN cord-028721-x6f26ahr 4489 24 of of IN cord-028721-x6f26ahr 4489 25 the the DT cord-028721-x6f26ahr 4489 26 rete rete NN cord-028721-x6f26ahr 4489 27 testis testis NN cord-028721-x6f26ahr 4489 28 Tubular tubular JJ cord-028721-x6f26ahr 4489 29 ectasia ectasia NNS cord-028721-x6f26ahr 4489 30 of of IN cord-028721-x6f26ahr 4489 31 the the DT cord-028721-x6f26ahr 4489 32 rete rete NNP cord-028721-x6f26ahr 4489 33 testis testis NN cord-028721-x6f26ahr 4489 34 : : : cord-028721-x6f26ahr 4489 35 an an DT cord-028721-x6f26ahr 4489 36 ultrasound ultrasound NN cord-028721-x6f26ahr 4489 37 diagnosis diagnosis NN cord-028721-x6f26ahr 4490 1 Cystic cystic JJ cord-028721-x6f26ahr 4490 2 ectasia ectasia NNS cord-028721-x6f26ahr 4490 3 of of IN cord-028721-x6f26ahr 4490 4 the the DT cord-028721-x6f26ahr 4490 5 rete rete NN cord-028721-x6f26ahr 4490 6 testis testis NN cord-028721-x6f26ahr 4490 7 Pronounced pronounced JJ cord-028721-x6f26ahr 4490 8 cystic cystic JJ cord-028721-x6f26ahr 4490 9 transformation transformation NN cord-028721-x6f26ahr 4490 10 of of IN cord-028721-x6f26ahr 4490 11 the the DT cord-028721-x6f26ahr 4490 12 rete rete NN cord-028721-x6f26ahr 4490 13 testis testis NN cord-028721-x6f26ahr 4490 14 . . . cord-028721-x6f26ahr 4491 1 MRI MRI NNP cord-028721-x6f26ahr 4491 2 appearance appearance NN cord-028721-x6f26ahr 4492 1 The the DT cord-028721-x6f26ahr 4492 2 diversity diversity NN cord-028721-x6f26ahr 4492 3 of of IN cord-028721-x6f26ahr 4492 4 reproductive reproductive JJ cord-028721-x6f26ahr 4492 5 tract tract JJ cord-028721-x6f26ahr 4492 6 abnormalities abnormality NNS cord-028721-x6f26ahr 4492 7 in in IN cord-028721-x6f26ahr 4492 8 males male NNS cord-028721-x6f26ahr 4492 9 with with IN cord-028721-x6f26ahr 4492 10 cystic cystic NN cord-028721-x6f26ahr 4492 11 fi fi NN cord-028721-x6f26ahr 4492 12 brosis brosis NN cord-028721-x6f26ahr 4492 13 Postsurgical Postsurgical NNP cord-028721-x6f26ahr 4492 14 changes change NNS cord-028721-x6f26ahr 4492 15 in in IN cord-028721-x6f26ahr 4492 16 the the DT cord-028721-x6f26ahr 4492 17 testis testis NN cord-028721-x6f26ahr 4492 18 : : : cord-028721-x6f26ahr 4492 19 a a DT cord-028721-x6f26ahr 4492 20 diagnostic diagnostic JJ cord-028721-x6f26ahr 4492 21 dilemma dilemma NN cord-028721-x6f26ahr 4492 22 Acquired acquire VBD cord-028721-x6f26ahr 4492 23 cystic cystic JJ cord-028721-x6f26ahr 4492 24 transformation transformation NN cord-028721-x6f26ahr 4492 25 of of IN cord-028721-x6f26ahr 4492 26 the the DT cord-028721-x6f26ahr 4492 27 rete rete NN cord-028721-x6f26ahr 4492 28 testis testis NN cord-028721-x6f26ahr 4492 29 secondary secondary JJ cord-028721-x6f26ahr 4492 30 to to IN cord-028721-x6f26ahr 4492 31 renal renal JJ cord-028721-x6f26ahr 4492 32 failure failure NN cord-028721-x6f26ahr 4493 1 Adenomatous adenomatous JJ cord-028721-x6f26ahr 4493 2 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4493 3 of of IN cord-028721-x6f26ahr 4493 4 the the DT cord-028721-x6f26ahr 4493 5 rete rete NN cord-028721-x6f26ahr 4493 6 testis testis NN cord-028721-x6f26ahr 4493 7 Adenomatous adenomatous JJ cord-028721-x6f26ahr 4493 8 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4493 9 of of IN cord-028721-x6f26ahr 4493 10 the the DT cord-028721-x6f26ahr 4493 11 rete rete NN cord-028721-x6f26ahr 4493 12 testis testis NN cord-028721-x6f26ahr 4493 13 . . . cord-028721-x6f26ahr 4494 1 A a DT cord-028721-x6f26ahr 4494 2 review review NN cord-028721-x6f26ahr 4494 3 and and CC cord-028721-x6f26ahr 4494 4 report report NN cord-028721-x6f26ahr 4494 5 of of IN cord-028721-x6f26ahr 4494 6 new new JJ cord-028721-x6f26ahr 4494 7 cases case NNS cord-028721-x6f26ahr 4495 1 Displasia Displasia NNP cord-028721-x6f26ahr 4495 2 quística quística NNP cord-028721-x6f26ahr 4495 3 del del NNP cord-028721-x6f26ahr 4495 4 testículo testículo NNP cord-028721-x6f26ahr 4495 5 : : : cord-028721-x6f26ahr 4496 1 anomalia anomalia NNP cord-028721-x6f26ahr 4496 2 en en IN cord-028721-x6f26ahr 4496 3 la la NNP cord-028721-x6f26ahr 4496 4 diferenciación diferenciación NNP cord-028721-x6f26ahr 4496 5 del del FW cord-028721-x6f26ahr 4496 6 parénquima parénquima NNP cord-028721-x6f26ahr 4496 7 testicular testicular NNP cord-028721-x6f26ahr 4496 8 por por FW cord-028721-x6f26ahr 4496 9 probable probable JJ cord-028721-x6f26ahr 4496 10 fallo fallo NNP cord-028721-x6f26ahr 4496 11 en en FW cord-028721-x6f26ahr 4496 12 la la FW cord-028721-x6f26ahr 4496 13 conexión conexión NNP cord-028721-x6f26ahr 4496 14 entre entre NNP cord-028721-x6f26ahr 4496 15 los los NNP cord-028721-x6f26ahr 4496 16 conductos conductos NNP cord-028721-x6f26ahr 4496 17 de de FW cord-028721-x6f26ahr 4496 18 origen origen NNP cord-028721-x6f26ahr 4496 19 mesonéfrico mesonéfrico NNP cord-028721-x6f26ahr 4496 20 y y NNP cord-028721-x6f26ahr 4496 21 los los NNP cord-028721-x6f26ahr 4496 22 cordones cordones NNP cord-028721-x6f26ahr 4496 23 testiculares testiculares NNP cord-028721-x6f26ahr 4496 24 Adenomatous adenomatous JJ cord-028721-x6f26ahr 4496 25 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4496 26 of of IN cord-028721-x6f26ahr 4496 27 the the DT cord-028721-x6f26ahr 4496 28 References References NNPS cord-028721-x6f26ahr 4496 29 rete rete NNP cord-028721-x6f26ahr 4496 30 testis testis NN cord-028721-x6f26ahr 4496 31 : : : cord-028721-x6f26ahr 4496 32 report report NN cord-028721-x6f26ahr 4496 33 of of IN cord-028721-x6f26ahr 4496 34 two two CD cord-028721-x6f26ahr 4496 35 cases case NNS cord-028721-x6f26ahr 4497 1 Glandular glandular JJ cord-028721-x6f26ahr 4497 2 changes change NNS cord-028721-x6f26ahr 4497 3 in in IN cord-028721-x6f26ahr 4497 4 the the DT cord-028721-x6f26ahr 4497 5 rete rete NNP cord-028721-x6f26ahr 4497 6 testis testis NN cord-028721-x6f26ahr 4497 7 : : : cord-028721-x6f26ahr 4497 8 metastatic metastatic JJ cord-028721-x6f26ahr 4497 9 tumour tumour NN cord-028721-x6f26ahr 4497 10 or or CC cord-028721-x6f26ahr 4497 11 adenomatous adenomatous JJ cord-028721-x6f26ahr 4497 12 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4497 13 ? ? . cord-028721-x6f26ahr 4498 1 [ [ -LRB- cord-028721-x6f26ahr 4498 2 Letter letter NN cord-028721-x6f26ahr 4498 3 Tumors tumor NNS cord-028721-x6f26ahr 4498 4 and and CC cord-028721-x6f26ahr 4498 5 cysts cyst NNS cord-028721-x6f26ahr 4498 6 of of IN cord-028721-x6f26ahr 4498 7 the the DT cord-028721-x6f26ahr 4498 8 paratesticular paratesticular JJ cord-028721-x6f26ahr 4498 9 region region NN cord-028721-x6f26ahr 4498 10 Adenomatous adenomatous JJ cord-028721-x6f26ahr 4498 11 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4498 12 of of IN cord-028721-x6f26ahr 4498 13 the the DT cord-028721-x6f26ahr 4498 14 rete rete NN cord-028721-x6f26ahr 4498 15 testis testis NN cord-028721-x6f26ahr 4498 16 . . . cord-028721-x6f26ahr 4499 1 A a DT cord-028721-x6f26ahr 4499 2 clinicopathologic clinicopathologic JJ cord-028721-x6f26ahr 4499 3 study study NN cord-028721-x6f26ahr 4499 4 of of IN cord-028721-x6f26ahr 4499 5 nine nine CD cord-028721-x6f26ahr 4499 6 cases case NNS cord-028721-x6f26ahr 4499 7 Primary primary JJ cord-028721-x6f26ahr 4499 8 testicular testicular JJ cord-028721-x6f26ahr 4499 9 lesions lesion NNS cord-028721-x6f26ahr 4499 10 are be VBP cord-028721-x6f26ahr 4499 11 associated associate VBN cord-028721-x6f26ahr 4499 12 with with IN cord-028721-x6f26ahr 4499 13 testicular testicular JJ cord-028721-x6f26ahr 4499 14 germ germ NN cord-028721-x6f26ahr 4499 15 cell cell NN cord-028721-x6f26ahr 4499 16 tumors tumor NNS cord-028721-x6f26ahr 4499 17 of of IN cord-028721-x6f26ahr 4499 18 adult adult NN cord-028721-x6f26ahr 4499 19 men man NNS cord-028721-x6f26ahr 4499 20 Adénome Adénome NNP cord-028721-x6f26ahr 4499 21 du du NNP cord-028721-x6f26ahr 4499 22 rete rete NN cord-028721-x6f26ahr 4499 23 testis testis NN cord-028721-x6f26ahr 4499 24 Adenocarcinoma Adenocarcinoma NNP cord-028721-x6f26ahr 4499 25 of of IN cord-028721-x6f26ahr 4499 26 the the DT cord-028721-x6f26ahr 4499 27 rete rete NNP cord-028721-x6f26ahr 4499 28 testis testis NN cord-028721-x6f26ahr 4499 29 : : : cord-028721-x6f26ahr 4499 30 case case NN cord-028721-x6f26ahr 4499 31 report report NN cord-028721-x6f26ahr 4499 32 , , , cord-028721-x6f26ahr 4499 33 ultrastructural ultrastructural JJ cord-028721-x6f26ahr 4499 34 observations observation NNS cord-028721-x6f26ahr 4499 35 , , , cord-028721-x6f26ahr 4499 36 and and CC cord-028721-x6f26ahr 4499 37 clinicopathologic clinicopathologic NNP cord-028721-x6f26ahr 4499 38 correlates correlate VBZ cord-028721-x6f26ahr 4500 1 Infarcted Infarcted NNP cord-028721-x6f26ahr 4500 2 adenomatoid adenomatoid NNP cord-028721-x6f26ahr 4500 3 tumor tumor NN cord-028721-x6f26ahr 4500 4 : : : cord-028721-x6f26ahr 4501 1 a a DT cord-028721-x6f26ahr 4501 2 report report NN cord-028721-x6f26ahr 4501 3 of of IN cord-028721-x6f26ahr 4501 4 fi fi NNP cord-028721-x6f26ahr 4501 5 ve ve VBD cord-028721-x6f26ahr 4501 6 cases case NNS cord-028721-x6f26ahr 4501 7 of of IN cord-028721-x6f26ahr 4501 8 a a DT cord-028721-x6f26ahr 4501 9 facet facet NN cord-028721-x6f26ahr 4501 10 of of IN cord-028721-x6f26ahr 4501 11 a a DT cord-028721-x6f26ahr 4501 12 benign benign JJ cord-028721-x6f26ahr 4501 13 neoplasm neoplasm NN cord-028721-x6f26ahr 4501 14 that that WDT cord-028721-x6f26ahr 4501 15 may may MD cord-028721-x6f26ahr 4501 16 cause cause VB cord-028721-x6f26ahr 4501 17 diagnostic diagnostic JJ cord-028721-x6f26ahr 4501 18 diffi diffi NNP cord-028721-x6f26ahr 4501 19 culty culty FW cord-028721-x6f26ahr 4501 20 Rete Rete NNP cord-028721-x6f26ahr 4501 21 testis testis NN cord-028721-x6f26ahr 4501 22 hyperplasia hyperplasia NN cord-028721-x6f26ahr 4501 23 with with IN cord-028721-x6f26ahr 4501 24 hyaline hyaline JJ cord-028721-x6f26ahr 4501 25 globule globule NN cord-028721-x6f26ahr 4501 26 formation formation NN cord-028721-x6f26ahr 4501 27 . . . cord-028721-x6f26ahr 4502 1 A a DT cord-028721-x6f26ahr 4502 2 lesion lesion NN cord-028721-x6f26ahr 4502 3 simulating simulate VBG cord-028721-x6f26ahr 4502 4 yolk yolk NN cord-028721-x6f26ahr 4502 5 sac sac NN cord-028721-x6f26ahr 4502 6 tumor tumor NN cord-028721-x6f26ahr 4502 7 Nodular Nodular NNP cord-028721-x6f26ahr 4502 8 proliferation proliferation NN cord-028721-x6f26ahr 4502 9 of of IN cord-028721-x6f26ahr 4502 10 calcifying calcify VBG cord-028721-x6f26ahr 4502 11 connective connective JJ cord-028721-x6f26ahr 4502 12 tissue tissue NN cord-028721-x6f26ahr 4502 13 in in IN cord-028721-x6f26ahr 4502 14 the the DT cord-028721-x6f26ahr 4502 15 rete rete NN cord-028721-x6f26ahr 4502 16 testis testis NN cord-028721-x6f26ahr 4502 17 : : : cord-028721-x6f26ahr 4502 18 A a DT cord-028721-x6f26ahr 4502 19 study study NN cord-028721-x6f26ahr 4502 20 of of IN cord-028721-x6f26ahr 4502 21 three three CD cord-028721-x6f26ahr 4502 22 cases case NNS