id author title date pages extension mime words sentences flesch summary cache txt cord-283450-w6scpc65 Amariei, Raluca The United States and Canada as a coupled epidemiological system: An example from hepatitis A 2008-02-28 .txt text/plain 6687 336 53 The objective of this study was to use dynamic models to investigate the possible effects on hepatitis A incidence in Canada due to (1) implementing vaccination in the US, and (2) varying the volume of travel by Canadians to the US. Our age-structured SEIRV compartmental model stratifies individuals according to epidemiologic status (Susceptible-Exposed-Infectious-Recovered-Vaccinated) and age class (ages 0-4, 5-9, 10-19, 20-29, 30-39, 40Maternal immunity is short-lived and affects relatively few individuals in a non-endemic country such as Canada, so we do not include it [10] . The rate at which a susceptible person is infected due to travel in endemic countries ( ), and the rate at which a susceptible person is infected by infectious persons due to domestic US transmission ( ) were computed simultaneously using: (1) published data on the true incidence of hepatitis A in the US, adjusted for under-reporting and the probability of jaundice [8] , (2) data on the age-specific proportion of cases attributable to travel in endemic countries [13] , and (3) an assumed form for a "Who Acquires Infection From ./cache/cord-283450-w6scpc65.txt ./txt/cord-283450-w6scpc65.txt