id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352563-yb446bap	Li, Ya	Bat adeno-associated viruses as gene therapy vectors with the potential to evade human neutralizing antibodies	2019-05-20		.txt	text/plain	6455	325	53	Bat AAVs could only slightly infect mouse liver but could transduce mouse muscle to some extent after systemic administration with a higher muscle/liver ratio than that of primate AAVs. Bat AAV 10HB showed moderate muscle transduction, similar to that of AAV2, during direct intramuscular injection and, compared with other AAV serotypes, was also relatively efficient in resisting human antibody neutralization after intramuscular injection. In this study, a number of bat AAV capsid genes will be cloned and characterized with a focus on their tissue tropism and immunological properties, which will establish a foundation for their further application in gene therapy, especially in the presence of human AAV antibodies. Considering both its moderate transduction of mouse muscle and efficient evasion of human antibody neutralization, the bat AAV 10HB vector exhibited the potential to be used for muscular gene therapy in humans.	./cache/cord-352563-yb446bap.txt	./txt/cord-352563-yb446bap.txt