id author title date pages extension mime words sentences flesch summary cache txt cord-277039-yo5ojr0s Mendenhall, Ian H. Discovery and Characterization of Novel Bat Coronavirus Lineages from Kazakhstan 2019-04-17 .txt text/plain 2419 133 55 In this study, bat guano was collected from bat caves in three different sites of southern Kazakhstan that tested positive for coronaviruses. The zoonotic SARS-coronavirus (SARS-CoV) outbreak originated in southern China from horseshoe bats, where wet markets permitted atypical contact between species, including subsequent spillover to humans [9] . On the other hand, camels are the putative natural reservoir for MERS-coronavirus, although recent phylogenetic analysis indicated that bats harbor coronaviruses that are ancestral to the MERS-CoV lineage [11] . In this study, we collected fresh bat guano from three caves at different locations in Kazakhstan and conducted molecular screening for coronaviruses. To further understand the evolutionary relationships of these viruses, we analyzed novel bat coronavirus sequences in combination with 2811 RdRp sequences of coronavirus from different host species worldwide, representing the three genera: Alpha-, Beta-, and Gamma-coronaviruses. The Alpha-CoV genus comprises a large number of coronaviruses from diverse hosts, including bats, shrews, dogs, cats, ferrets, pigs, and humans. ./cache/cord-277039-yo5ojr0s.txt ./txt/cord-277039-yo5ojr0s.txt