id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003757-uwbpbai7	Chionh, Yok Teng	High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress	2019-06-22		.txt	text/plain	7718	464	60	Heat shock protein (HSP), highly conserved master regulators of cell stress, expression was examined across tissues and various cell lines in bats. Here, we show that bats have elevated expression of heat shock proteins (HSPs) in various tissue and cell lines from two species, comparative sequence analysis of HSPs from ten bat species and that increased HSP expression in vitro confers survival of cells during prolonged heat stress. For kidney, we found that PaKiT03 (bat) cells expressed significantly higher amounts of HSP70 and HSP90A/B both at the mRNA (Fig. 2b-d) and protein levels (Fig. 2e) at 37°C compared to the MDCK (dog) and BHK (hamster) cells under normal conditions. The basal expression level of several HSP genes is genetically imprinted in vivo in live animal-derived tissues from two species of bat, with cultured cell lines displaying the same high expression.	./cache/cord-003757-uwbpbai7.txt	./txt/cord-003757-uwbpbai7.txt