id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335709-pta3nzz9	Murphy, Caitlin N.	Multicenter Evaluation of the BioFire FilmArray Pneumonia/Pneumonia Plus Panel for Detection and Quantification of Agents of Lower Respiratory Tract Infection	2020-06-24		.txt	text/plain	8013	350	40	This study assessed the performance of the BioFire FilmArray Pneumonia Panel (PN panel) and Pneumonia Plus Panel (PNplus panel), an FDA-cleared sample-to-answer assay that enables the detection of viruses, atypical bacteria, bacteria, and antimicrobial resistance marker genes from lower respiratory tract specimens (sputum and bronchoalveolar lavage [BAL] fluid). Prospectively collected respiratory specimens (846 BAL and 836 sputum specimens) evaluated with the PN panel were also tested by quantitative reference culture and molecular methods for comparison. Dilutions of contrived BAL samples containing cultured bacterial isolates in a matrix of sterile physiological saline and 20 ng/l human genomic DNA were tested repeatedly with the PN panel (90 replicates) to assess both the linearity and accuracy of the test's semiquantitative bin results. Validation testing demonstrated that most assays (at least one or both per analyte in both BAL and sputum sample types) had a limit of detection (LoD) that was within at least 5-fold that of the PN panel, which was considered "equivalent" sensitivity.	./cache/cord-335709-pta3nzz9.txt	./txt/cord-335709-pta3nzz9.txt