id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306346-rft22vo8	Rohde, G.	CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations	2014-06-23		.txt	text/plain	4658	260	48	METHODS: Protein levels of antimicrobial peptides (SLPI, HNP 1–3, elafin, and LL‐37) and neutrophil chemokines (CXCL1/GRO‐α, CXCL2/GRO‐β, CXCL5/ENA‐78, CXCL6/GCP‐2, CXCL7/NAP‐2, and CXCL8/IL‐8) were determined in bronchoalveolar lavage (BAL) fluid of 10 asthmatics and 15 normal controls taken before, at day four during and 6 weeks post‐experimental infection. It has been hypothesized that human rhinovirus infections should increase levels of a-defensins in the airways [10] , as they lead to marked neutrophil infiltration and degranulation in the airways [11] which are associated with clinical severity of virus-induced asthma [5, 12] . To test this hypothesis and to clarify whether this possible induction is related to airway neutrophilia and the expression of CXC chemokines, we analysed the expression of neutrophil antimicrobial peptides and CXC chemokines in BAL fluid of subjects with RV-induced experimental asthma exacerbations. Four days after infection, BAL HNP 1-3 and elafin were significantly higher in asthmatics compared with controls Repeated-measures multivariate analysis showed significant differences only in asthmatic subjects.	./cache/cord-306346-rft22vo8.txt	./txt/cord-306346-rft22vo8.txt