id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291960-1is0rv6c	Piñana, José Luis	Pulmonary cytomegalovirus (CMV) DNA shedding in allogeneic hematopoietic stem cell transplant recipients: Implications for the diagnosis of CMV pneumonia	2019-02-21		.txt	text/plain	5915	280	44	OBJECTIVES: To date no definitive cut-off value for cytomegalovirus (CMV) DNA load in bronchoalveolar lavage (BAL) fluid specimens has been established to discriminate between CMV pneumonia and pulmonary CMV DNA shedding in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. METHODS: The current retrospective study is aimed at assessing the range of CMV DNA loads quantified in BAL fluid specimens from allo-HSCT patients with pneumonia in which different microorganisms were causally involved. CMV pneumonitis was deemed to be unlikely in these patients owing to one or more of the following: (i) lack of typical findings in CTs (in all episodes); (ii) negative BAL cytospin results (in 25 episodes); (iii) negative lung histopathology at autopsy (in Table 2 Pneumonia attributable etiology and microbiological findings in bronchoalveolar lavage fluid specimens. First, we confirmed previous observations 8 -10 indicating that detection of CMV DNA in BAL fluid specimens using highly-sensitive PCR assays is a very common finding in allo-HSCT patients with pneumonia, irrespective of the definitive etiological diagnosis.	./cache/cord-291960-1is0rv6c.txt	./txt/cord-291960-1is0rv6c.txt