id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-328918-nc0a77r6	Kuczia, Pawel	Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients	2020-07-13		.txt	text/plain	4458	287	45	title: Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients In the present study we have evaluated circulating H3cit in stable asthmatics and investigated its relationship with asthma severity, pulmonary function and selected blood and bronchoalveolar lavage (BAL) biomarkers. We have recently reported evidence of a prothrombotic state in asthma which is characterized by enhanced plasma thrombin formation, impaired clot lysis and platelet activation [13] , all of them related to the low-grade systemic inflammation [3] , endothelial injury [14] , elevated exacerbation rate [15] , and likely increased atherosclerotic risk [16, 17] . In the present study we have demonstrated that serum H3cit, a novel biomarker of ETs formation, is increased in stable asthma subjects. Asthma is characterized by increased circulating H3cit likely related to the enhanced lung ETs formation.	./cache/cord-328918-nc0a77r6.txt	./txt/cord-328918-nc0a77r6.txt