id	sid	tid	token	lemma	pos
cord-034687-57n88v6t	1	1	key	key	JJ
cord-034687-57n88v6t	1	2	:	:	:
cord-034687-57n88v6t	1	3	cord-034687	cord-034687	NNP
cord-034687-57n88v6t	1	4	-	-	HYPH
cord-034687-57n88v6t	1	5	57n88v6	57n88v6	CD
cord-034687-57n88v6t	1	6	t	t	NN
cord-034687-57n88v6t	1	7	authors	author	NNS
cord-034687-57n88v6t	1	8	:	:	:
cord-034687-57n88v6t	1	9	Maldonado	Maldonado	NNP
cord-034687-57n88v6t	1	10	,	,	,
cord-034687-57n88v6t	1	11	Rafael	Rafael	NNP
cord-034687-57n88v6t	1	12	;	;	:
cord-034687-57n88v6t	1	13	Cabañero	Cabañero	NNP
cord-034687-57n88v6t	1	14	,	,	,
cord-034687-57n88v6t	1	15	David	David	NNP
cord-034687-57n88v6t	1	16	;	;	:
cord-034687-57n88v6t	1	17	Martín	Martín	NNP
cord-034687-57n88v6t	1	18	-	-	HYPH
cord-034687-57n88v6t	1	19	García	García	NNP
cord-034687-57n88v6t	1	20	,	,	,
cord-034687-57n88v6t	2	1	Elena	Elena	NNP
cord-034687-57n88v6t	2	2	title	title	NN
cord-034687-57n88v6t	2	3	:	:	:
cord-034687-57n88v6t	2	4	The	the	DT
cord-034687-57n88v6t	2	5	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	2	6	system	system	NN
cord-034687-57n88v6t	2	7	in	in	IN
cord-034687-57n88v6t	2	8	modulating	modulate	VBG
cord-034687-57n88v6t	2	9	fear	fear	NN
cord-034687-57n88v6t	2	10	,	,	,
cord-034687-57n88v6t	2	11	anxiety	anxiety	NN
cord-034687-57n88v6t	2	12	,	,	,
cord-034687-57n88v6t	2	13	and	and	CC
cord-034687-57n88v6t	2	14	stress	stress	NN
cord-034687-57n88v6t	2	15	date	date	NN
cord-034687-57n88v6t	2	16	:	:	:
cord-034687-57n88v6t	2	17	2020	2020	CD
cord-034687-57n88v6t	2	18	-	-	HYPH
cord-034687-57n88v6t	2	19	09	09	CD
cord-034687-57n88v6t	2	20	-	-	SYM
cord-034687-57n88v6t	2	21	17	17	CD
cord-034687-57n88v6t	2	22	journal	journal	NN
cord-034687-57n88v6t	2	23	:	:	:
cord-034687-57n88v6t	3	1	Dialogues	Dialogues	NNP
cord-034687-57n88v6t	3	2	Clin	Clin	NNP
cord-034687-57n88v6t	3	3	Neurosci	Neurosci	NNP
cord-034687-57n88v6t	3	4	DOI	doi	NN
cord-034687-57n88v6t	3	5	:	:	:
cord-034687-57n88v6t	3	6	10.31887/	10.31887/	NNP
cord-034687-57n88v6t	4	1	dcns.2020.22.3	dcns.2020.22.3	NNP
cord-034687-57n88v6t	5	1	/rmaldonado	/rmaldonado	,
cord-034687-57n88v6t	5	2	sha	sha	NNP
cord-034687-57n88v6t	5	3	:	:	:
cord-034687-57n88v6t	6	1	cdaeede270dead28cefc2f9b64d1382943ddbe15	cdaeede270dead28cefc2f9b64d1382943ddbe15	NNP
cord-034687-57n88v6t	6	2	doc_id	doc_id	CD
cord-034687-57n88v6t	6	3	:	:	:
cord-034687-57n88v6t	7	1	34687	34687	CD
cord-034687-57n88v6t	7	2	cord_uid	cord_uid	NNS
cord-034687-57n88v6t	7	3	:	:	:
cord-034687-57n88v6t	8	1	57n88v6	57n88v6	CD
cord-034687-57n88v6t	9	1	t	t	NNP
cord-034687-57n88v6t	10	1	The	the	DT
cord-034687-57n88v6t	10	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	10	3	system	system	NN
cord-034687-57n88v6t	10	4	is	be	VBZ
cord-034687-57n88v6t	10	5	widely	widely	RB
cord-034687-57n88v6t	10	6	expressed	express	VBN
cord-034687-57n88v6t	10	7	in	in	IN
cord-034687-57n88v6t	10	8	the	the	DT
cord-034687-57n88v6t	10	9	limbic	limbic	NNP
cord-034687-57n88v6t	10	10	system	system	NN
cord-034687-57n88v6t	10	11	,	,	,
cord-034687-57n88v6t	10	12	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	10	13	cortical	cortical	JJ
cord-034687-57n88v6t	10	14	areas	area	NNS
cord-034687-57n88v6t	10	15	,	,	,
cord-034687-57n88v6t	10	16	and	and	CC
cord-034687-57n88v6t	10	17	brain	brain	NN
cord-034687-57n88v6t	10	18	structures	structure	NNS
cord-034687-57n88v6t	10	19	regulating	regulate	VBG
cord-034687-57n88v6t	10	20	neuroendocrine	neuroendocrine	JJ
cord-034687-57n88v6t	10	21	stress	stress	NN
cord-034687-57n88v6t	10	22	responses	response	NNS
cord-034687-57n88v6t	10	23	,	,	,
cord-034687-57n88v6t	10	24	which	which	WDT
cord-034687-57n88v6t	10	25	explains	explain	VBZ
cord-034687-57n88v6t	10	26	the	the	DT
cord-034687-57n88v6t	10	27	key	key	JJ
cord-034687-57n88v6t	10	28	role	role	NN
cord-034687-57n88v6t	10	29	of	of	IN
cord-034687-57n88v6t	10	30	this	this	DT
cord-034687-57n88v6t	10	31	system	system	NN
cord-034687-57n88v6t	10	32	in	in	IN
cord-034687-57n88v6t	10	33	the	the	DT
cord-034687-57n88v6t	10	34	control	control	NN
cord-034687-57n88v6t	10	35	of	of	IN
cord-034687-57n88v6t	10	36	emotions	emotion	NNS
cord-034687-57n88v6t	10	37	.	.	.
cord-034687-57n88v6t	11	1	In	in	IN
cord-034687-57n88v6t	11	2	this	this	DT
cord-034687-57n88v6t	11	3	review	review	NN
cord-034687-57n88v6t	11	4	,	,	,
cord-034687-57n88v6t	11	5	we	-PRON-	PRP
cord-034687-57n88v6t	11	6	update	update	VBP
cord-034687-57n88v6t	11	7	recent	recent	JJ
cord-034687-57n88v6t	11	8	advances	advance	NNS
cord-034687-57n88v6t	11	9	on	on	IN
cord-034687-57n88v6t	11	10	the	the	DT
cord-034687-57n88v6t	11	11	function	function	NN
cord-034687-57n88v6t	11	12	of	of	IN
cord-034687-57n88v6t	11	13	the	the	DT
cord-034687-57n88v6t	11	14	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	11	15	system	system	NN
cord-034687-57n88v6t	11	16	in	in	IN
cord-034687-57n88v6t	11	17	determining	determine	VBG
cord-034687-57n88v6t	11	18	the	the	DT
cord-034687-57n88v6t	11	19	value	value	NN
cord-034687-57n88v6t	11	20	of	of	IN
cord-034687-57n88v6t	11	21	fear	fear	NN
cord-034687-57n88v6t	11	22	-	-	HYPH
cord-034687-57n88v6t	11	23	evoking	evoke	VBG
cord-034687-57n88v6t	11	24	stimuli	stimulus	NNS
cord-034687-57n88v6t	11	25	and	and	CC
cord-034687-57n88v6t	11	26	promoting	promote	VBG
cord-034687-57n88v6t	11	27	appropriate	appropriate	JJ
cord-034687-57n88v6t	11	28	behavioral	behavioral	JJ
cord-034687-57n88v6t	11	29	responses	response	NNS
cord-034687-57n88v6t	11	30	for	for	IN
cord-034687-57n88v6t	11	31	stress	stress	NN
cord-034687-57n88v6t	11	32	resilience	resilience	NN
cord-034687-57n88v6t	11	33	.	.	.
cord-034687-57n88v6t	12	1	We	-PRON-	PRP
cord-034687-57n88v6t	12	2	also	also	RB
cord-034687-57n88v6t	12	3	review	review	VBP
cord-034687-57n88v6t	12	4	the	the	DT
cord-034687-57n88v6t	12	5	alterations	alteration	NNS
cord-034687-57n88v6t	12	6	in	in	IN
cord-034687-57n88v6t	12	7	the	the	DT
cord-034687-57n88v6t	12	8	activity	activity	NN
cord-034687-57n88v6t	12	9	of	of	IN
cord-034687-57n88v6t	12	10	the	the	DT
cord-034687-57n88v6t	12	11	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	12	12	system	system	NN
cord-034687-57n88v6t	12	13	during	during	IN
cord-034687-57n88v6t	12	14	fear	fear	NN
cord-034687-57n88v6t	12	15	,	,	,
cord-034687-57n88v6t	12	16	stress	stress	NN
cord-034687-57n88v6t	12	17	,	,	,
cord-034687-57n88v6t	12	18	and	and	CC
cord-034687-57n88v6t	12	19	anxiety	anxiety	NN
cord-034687-57n88v6t	12	20	,	,	,
cord-034687-57n88v6t	12	21	and	and	CC
cord-034687-57n88v6t	12	22	the	the	DT
cord-034687-57n88v6t	12	23	pathophysiological	pathophysiological	JJ
cord-034687-57n88v6t	12	24	role	role	NN
cord-034687-57n88v6t	12	25	of	of	IN
cord-034687-57n88v6t	12	26	each	each	DT
cord-034687-57n88v6t	12	27	component	component	NN
cord-034687-57n88v6t	12	28	of	of	IN
cord-034687-57n88v6t	12	29	this	this	DT
cord-034687-57n88v6t	12	30	system	system	NN
cord-034687-57n88v6t	12	31	in	in	IN
cord-034687-57n88v6t	12	32	the	the	DT
cord-034687-57n88v6t	12	33	control	control	NN
cord-034687-57n88v6t	12	34	of	of	IN
cord-034687-57n88v6t	12	35	these	these	DT
cord-034687-57n88v6t	12	36	protective	protective	JJ
cord-034687-57n88v6t	12	37	emotional	emotional	JJ
cord-034687-57n88v6t	12	38	responses	response	NNS
cord-034687-57n88v6t	12	39	that	that	WDT
cord-034687-57n88v6t	12	40	also	also	RB
cord-034687-57n88v6t	12	41	trigger	trigger	VB
cord-034687-57n88v6t	12	42	pathological	pathological	JJ
cord-034687-57n88v6t	12	43	emotional	emotional	JJ
cord-034687-57n88v6t	12	44	disorders	disorder	NNS
cord-034687-57n88v6t	12	45	.	.	.
cord-034687-57n88v6t	13	1	In	in	IN
cord-034687-57n88v6t	13	2	spite	spite	NN
cord-034687-57n88v6t	13	3	of	of	IN
cord-034687-57n88v6t	13	4	all	all	PDT
cord-034687-57n88v6t	13	5	the	the	DT
cord-034687-57n88v6t	13	6	evidence	evidence	NN
cord-034687-57n88v6t	13	7	,	,	,
cord-034687-57n88v6t	13	8	we	-PRON-	PRP
cord-034687-57n88v6t	13	9	have	have	VBP
cord-034687-57n88v6t	13	10	not	not	RB
cord-034687-57n88v6t	13	11	yet	yet	RB
cord-034687-57n88v6t	13	12	taken	take	VBN
cord-034687-57n88v6t	13	13	advantage	advantage	NN
cord-034687-57n88v6t	13	14	of	of	IN
cord-034687-57n88v6t	13	15	the	the	DT
cord-034687-57n88v6t	13	16	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	13	17	implications	implication	NNS
cord-034687-57n88v6t	13	18	of	of	IN
cord-034687-57n88v6t	13	19	this	this	DT
cord-034687-57n88v6t	13	20	important	important	JJ
cord-034687-57n88v6t	13	21	role	role	NN
cord-034687-57n88v6t	13	22	of	of	IN
cord-034687-57n88v6t	13	23	the	the	DT
cord-034687-57n88v6t	13	24	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	13	25	system	system	NN
cord-034687-57n88v6t	13	26	,	,	,
cord-034687-57n88v6t	13	27	and	and	CC
cord-034687-57n88v6t	13	28	possible	possible	JJ
cord-034687-57n88v6t	13	29	future	future	JJ
cord-034687-57n88v6t	13	30	strategies	strategy	NNS
cord-034687-57n88v6t	13	31	to	to	TO
cord-034687-57n88v6t	13	32	improve	improve	VB
cord-034687-57n88v6t	13	33	the	the	DT
cord-034687-57n88v6t	13	34	treatment	treatment	NN
cord-034687-57n88v6t	13	35	of	of	IN
cord-034687-57n88v6t	13	36	these	these	DT
cord-034687-57n88v6t	13	37	emotional	emotional	JJ
cord-034687-57n88v6t	13	38	disorders	disorder	NNS
cord-034687-57n88v6t	13	39	are	be	VBP
cord-034687-57n88v6t	13	40	discussed	discuss	VBN
cord-034687-57n88v6t	13	41	.	.	.
cord-034687-57n88v6t	14	1	Anxiety	anxiety	NN
cord-034687-57n88v6t	14	2	disorders	disorder	NNS
cord-034687-57n88v6t	14	3	are	be	VBP
cord-034687-57n88v6t	14	4	the	the	DT
cord-034687-57n88v6t	14	5	most	most	RBS
cord-034687-57n88v6t	14	6	frequent	frequent	JJ
cord-034687-57n88v6t	14	7	mental	mental	JJ
cord-034687-57n88v6t	14	8	alterations	alteration	NNS
cord-034687-57n88v6t	14	9	worldwide	worldwide	RB
cord-034687-57n88v6t	14	10	in	in	IN
cord-034687-57n88v6t	14	11	different	different	JJ
cord-034687-57n88v6t	14	12	socioeconomic	socioeconomic	JJ
cord-034687-57n88v6t	14	13	regions	region	NNS
cord-034687-57n88v6t	14	14	and	and	CC
cord-034687-57n88v6t	14	15	are	be	VBP
cord-034687-57n88v6t	14	16	linked	link	VBN
cord-034687-57n88v6t	14	17	with	with	IN
cord-034687-57n88v6t	14	18	significant	significant	JJ
cord-034687-57n88v6t	14	19	comorbidities	comorbiditie	NNS
cord-034687-57n88v6t	14	20	.	.	.
cord-034687-57n88v6t	15	1	1	1	CD
cord-034687-57n88v6t	15	2	Fear	fear	NN
cord-034687-57n88v6t	15	3	and	and	CC
cord-034687-57n88v6t	15	4	worry	worry	NN
cord-034687-57n88v6t	15	5	are	be	VBP
cord-034687-57n88v6t	15	6	core	core	NN
cord-034687-57n88v6t	15	7	symptoms	symptom	NNS
cord-034687-57n88v6t	15	8	of	of	IN
cord-034687-57n88v6t	15	9	the	the	DT
cord-034687-57n88v6t	15	10	entire	entire	JJ
cord-034687-57n88v6t	15	11	spectrum	spectrum	NN
cord-034687-57n88v6t	15	12	of	of	IN
cord-034687-57n88v6t	15	13	anxiety	anxiety	NN
cord-034687-57n88v6t	15	14	disorders	disorder	NNS
cord-034687-57n88v6t	15	15	in	in	IN
cord-034687-57n88v6t	15	16	the	the	DT
cord-034687-57n88v6t	15	17	Diagnostic	Diagnostic	NNP
cord-034687-57n88v6t	15	18	and	and	CC
cord-034687-57n88v6t	15	19	Statistical	Statistical	NNP
cord-034687-57n88v6t	15	20	Manual	Manual	NNP
cord-034687-57n88v6t	15	21	of	of	IN
cord-034687-57n88v6t	15	22	Mental	Mental	NNP
cord-034687-57n88v6t	15	23	Disorders	Disorders	NNPS
cord-034687-57n88v6t	15	24	,	,	,
cord-034687-57n88v6t	15	25	5	5	CD
cord-034687-57n88v6t	15	26	th	th	XX
cord-034687-57n88v6t	15	27	Edition	edition	NN
cord-034687-57n88v6t	15	28	(	(	-LRB-
cord-034687-57n88v6t	15	29	DSM-5	DSM-5	NNP
cord-034687-57n88v6t	15	30	)	)	-RRB-
cord-034687-57n88v6t	15	31	.	.	.
cord-034687-57n88v6t	16	1	2	2	LS
cord-034687-57n88v6t	17	1	These	these	DT
cord-034687-57n88v6t	17	2	disorders	disorder	NNS
cord-034687-57n88v6t	17	3	have	have	VBP
cord-034687-57n88v6t	17	4	a	a	DT
cord-034687-57n88v6t	17	5	complex	complex	JJ
cord-034687-57n88v6t	17	6	and	and	CC
cord-034687-57n88v6t	17	7	multifactorial	multifactorial	JJ
cord-034687-57n88v6t	17	8	origin	origin	NN
cord-034687-57n88v6t	17	9	resulting	result	VBG
cord-034687-57n88v6t	17	10	from	from	IN
cord-034687-57n88v6t	17	11	the	the	DT
cord-034687-57n88v6t	17	12	interaction	interaction	NN
cord-034687-57n88v6t	17	13	of	of	IN
cord-034687-57n88v6t	17	14	multiple	multiple	JJ
cord-034687-57n88v6t	17	15	genes	gene	NNS
cord-034687-57n88v6t	17	16	and	and	CC
cord-034687-57n88v6t	17	17	environmental	environmental	JJ
cord-034687-57n88v6t	17	18	factors	factor	NNS
cord-034687-57n88v6t	17	19	that	that	WDT
cord-034687-57n88v6t	17	20	lead	lead	VBP
cord-034687-57n88v6t	17	21	to	to	IN
cord-034687-57n88v6t	17	22	large	large	JJ
cord-034687-57n88v6t	17	23	interindividual	interindividual	JJ
cord-034687-57n88v6t	17	24	variability	variability	NN
cord-034687-57n88v6t	17	25	.	.	.
cord-034687-57n88v6t	18	1	Chronic	chronic	JJ
cord-034687-57n88v6t	18	2	stress	stress	NN
cord-034687-57n88v6t	18	3	is	be	VBZ
cord-034687-57n88v6t	18	4	one	one	CD
cord-034687-57n88v6t	18	5	of	of	IN
cord-034687-57n88v6t	18	6	the	the	DT
cord-034687-57n88v6t	18	7	main	main	JJ
cord-034687-57n88v6t	18	8	environmental	environmental	JJ
cord-034687-57n88v6t	18	9	risk	risk	NN
cord-034687-57n88v6t	18	10	factors	factor	NNS
cord-034687-57n88v6t	18	11	that	that	WDT
cord-034687-57n88v6t	18	12	disrupt	disrupt	VBP
cord-034687-57n88v6t	18	13	coping	cope	VBG
cord-034687-57n88v6t	18	14	circuits	circuit	NNS
cord-034687-57n88v6t	18	15	and	and	CC
cord-034687-57n88v6t	18	16	contributes	contribute	VBZ
cord-034687-57n88v6t	18	17	to	to	IN
cord-034687-57n88v6t	18	18	the	the	DT
cord-034687-57n88v6t	18	19	etiopathology	etiopathology	NN
cord-034687-57n88v6t	18	20	of	of	IN
cord-034687-57n88v6t	18	21	these	these	DT
cord-034687-57n88v6t	18	22	psychiatric	psychiatric	JJ
cord-034687-57n88v6t	18	23	disorders	disorder	NNS
cord-034687-57n88v6t	18	24	.	.	.
cord-034687-57n88v6t	19	1	In	in	IN
cord-034687-57n88v6t	19	2	contrast	contrast	NN
cord-034687-57n88v6t	19	3	,	,	,
cord-034687-57n88v6t	19	4	exposure	exposure	NN
cord-034687-57n88v6t	19	5	to	to	IN
cord-034687-57n88v6t	19	6	mild	mild	JJ
cord-034687-57n88v6t	19	7	stress	stress	NN
cord-034687-57n88v6t	19	8	may	may	MD
cord-034687-57n88v6t	19	9	act	act	VB
cord-034687-57n88v6t	19	10	as	as	IN
cord-034687-57n88v6t	19	11	a	a	DT
cord-034687-57n88v6t	19	12	protective	protective	JJ
cord-034687-57n88v6t	19	13	factor	factor	NN
cord-034687-57n88v6t	19	14	by	by	IN
cord-034687-57n88v6t	19	15	improving	improve	VBG
cord-034687-57n88v6t	19	16	coping	cope	VBG
cord-034687-57n88v6t	19	17	strategies	strategy	NNS
cord-034687-57n88v6t	19	18	in	in	IN
cord-034687-57n88v6t	19	19	future	future	JJ
cord-034687-57n88v6t	19	20	stressful	stressful	JJ
cord-034687-57n88v6t	19	21	events	event	NNS
cord-034687-57n88v6t	19	22	.	.	.
cord-034687-57n88v6t	20	1	3	3	LS
cord-034687-57n88v6t	21	1	The	the	DT
cord-034687-57n88v6t	21	2	reasons	reason	NNS
cord-034687-57n88v6t	21	3	why	why	WRB
cord-034687-57n88v6t	21	4	some	some	DT
cord-034687-57n88v6t	21	5	individuals	individual	NNS
cord-034687-57n88v6t	21	6	exposed	expose	VBN
cord-034687-57n88v6t	21	7	to	to	IN
cord-034687-57n88v6t	21	8	similar	similar	JJ
cord-034687-57n88v6t	21	9	chronic	chronic	JJ
cord-034687-57n88v6t	21	10	stress	stress	NN
cord-034687-57n88v6t	21	11	are	be	VBP
cord-034687-57n88v6t	21	12	vulnerable	vulnerable	JJ
cord-034687-57n88v6t	21	13	and	and	CC
cord-034687-57n88v6t	21	14	develop	develop	VB
cord-034687-57n88v6t	21	15	anxiety	anxiety	NN
cord-034687-57n88v6t	21	16	disorders	disorder	NNS
cord-034687-57n88v6t	21	17	whereas	whereas	IN
cord-034687-57n88v6t	21	18	others	other	NNS
cord-034687-57n88v6t	21	19	are	be	VBP
cord-034687-57n88v6t	21	20	resilient	resilient	JJ
cord-034687-57n88v6t	21	21	remain	remain	VBP
cord-034687-57n88v6t	21	22	unknown	unknown	JJ
cord-034687-57n88v6t	21	23	.	.	.
cord-034687-57n88v6t	22	1	Importantly	importantly	RB
cord-034687-57n88v6t	22	2	,	,	,
cord-034687-57n88v6t	22	3	there	there	EX
cord-034687-57n88v6t	22	4	is	be	VBZ
cord-034687-57n88v6t	22	5	a	a	DT
cord-034687-57n88v6t	22	6	lack	lack	NN
cord-034687-57n88v6t	22	7	of	of	IN
cord-034687-57n88v6t	22	8	successful	successful	JJ
cord-034687-57n88v6t	22	9	treatments	treatment	NNS
cord-034687-57n88v6t	22	10	for	for	IN
cord-034687-57n88v6t	22	11	these	these	DT
cord-034687-57n88v6t	22	12	disorders	disorder	NNS
cord-034687-57n88v6t	22	13	,	,	,
cord-034687-57n88v6t	22	14	revealing	reveal	VBG
cord-034687-57n88v6t	22	15	an	an	DT
cord-034687-57n88v6t	22	16	urgent	urgent	JJ
cord-034687-57n88v6t	22	17	need	need	NN
cord-034687-57n88v6t	22	18	for	for	IN
cord-034687-57n88v6t	22	19	a	a	DT
cord-034687-57n88v6t	22	20	better	well	JJR
cord-034687-57n88v6t	22	21	understanding	understanding	NN
cord-034687-57n88v6t	22	22	of	of	IN
cord-034687-57n88v6t	22	23	their	-PRON-	PRP$
cord-034687-57n88v6t	22	24	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	22	25	mechanisms	mechanism	NNS
cord-034687-57n88v6t	22	26	.	.	.
cord-034687-57n88v6t	23	1	Remarkable	remarkable	JJ
cord-034687-57n88v6t	23	2	progress	progress	NN
cord-034687-57n88v6t	23	3	has	have	VBZ
cord-034687-57n88v6t	23	4	recently	recently	RB
cord-034687-57n88v6t	23	5	been	be	VBN
cord-034687-57n88v6t	23	6	made	make	VBN
cord-034687-57n88v6t	23	7	in	in	IN
cord-034687-57n88v6t	23	8	understanding	understand	VBG
cord-034687-57n88v6t	23	9	the	the	DT
cord-034687-57n88v6t	23	10	circuitries	circuitry	NNS
cord-034687-57n88v6t	23	11	underlying	underlie	VBG
cord-034687-57n88v6t	23	12	anxiety	anxiety	NN
cord-034687-57n88v6t	23	13	disorders	disorder	NNS
cord-034687-57n88v6t	23	14	.	.	.
cord-034687-57n88v6t	24	1	3	3	LS
cord-034687-57n88v6t	25	1	A	a	DT
cord-034687-57n88v6t	25	2	large	large	JJ
cord-034687-57n88v6t	25	3	amount	amount	NN
cord-034687-57n88v6t	25	4	of	of	IN
cord-034687-57n88v6t	25	5	this	this	DT
cord-034687-57n88v6t	25	6	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	25	7	research	research	NN
cord-034687-57n88v6t	25	8	has	have	VBZ
cord-034687-57n88v6t	25	9	been	be	VBN
cord-034687-57n88v6t	25	10	focused	focus	VBN
cord-034687-57n88v6t	25	11	on	on	IN
cord-034687-57n88v6t	25	12	networks	network	NNS
cord-034687-57n88v6t	25	13	targeting	target	VBG
cord-034687-57n88v6t	25	14	the	the	DT
cord-034687-57n88v6t	25	15	limbic	limbic	NN
cord-034687-57n88v6t	25	16	and	and	CC
cord-034687-57n88v6t	25	17	the	the	DT
cord-034687-57n88v6t	25	18	hypothalamic	hypothalamic	JJ
cord-034687-57n88v6t	25	19	-	-	HYPH
cord-034687-57n88v6t	25	20	pituitary	pituitary	NN
cord-034687-57n88v6t	25	21	-	-	HYPH
cord-034687-57n88v6t	25	22	adrenal	adrenal	NN
cord-034687-57n88v6t	25	23	(	(	-LRB-
cord-034687-57n88v6t	25	24	HPA	HPA	NNP
cord-034687-57n88v6t	25	25	)	)	-RRB-
cord-034687-57n88v6t	25	26	axis	axis	NN
cord-034687-57n88v6t	25	27	and	and	CC
cord-034687-57n88v6t	25	28	its	-PRON-	PRP$
cord-034687-57n88v6t	25	29	modulation	modulation	NN
cord-034687-57n88v6t	25	30	by	by	IN
cord-034687-57n88v6t	25	31	different	different	JJ
cord-034687-57n88v6t	25	32	neurotransmitters	neurotransmitter	NNS
cord-034687-57n88v6t	25	33	,	,	,
cord-034687-57n88v6t	25	34	with	with	IN
cord-034687-57n88v6t	25	35	special	special	JJ
cord-034687-57n88v6t	25	36	emphasis	emphasis	NN
cord-034687-57n88v6t	25	37	on	on	IN
cord-034687-57n88v6t	25	38	the	the	DT
cord-034687-57n88v6t	25	39	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	25	40	system	system	NN
cord-034687-57n88v6t	25	41	.	.	.
cord-034687-57n88v6t	26	1	The	the	DT
cord-034687-57n88v6t	26	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	26	3	system	system	NN
cord-034687-57n88v6t	26	4	is	be	VBZ
cord-034687-57n88v6t	26	5	extensively	extensively	RB
cord-034687-57n88v6t	26	6	distributed	distribute	VBN
cord-034687-57n88v6t	26	7	in	in	IN
cord-034687-57n88v6t	26	8	the	the	DT
cord-034687-57n88v6t	26	9	central	central	JJ
cord-034687-57n88v6t	26	10	nervous	nervous	JJ
cord-034687-57n88v6t	26	11	system	system	NN
cord-034687-57n88v6t	26	12	(	(	-LRB-
cord-034687-57n88v6t	26	13	CNS	CNS	NNP
cord-034687-57n88v6t	26	14	)	)	-RRB-
cord-034687-57n88v6t	26	15	and	and	CC
cord-034687-57n88v6t	26	16	plays	play	VBZ
cord-034687-57n88v6t	26	17	a	a	DT
cord-034687-57n88v6t	26	18	crucial	crucial	JJ
cord-034687-57n88v6t	26	19	role	role	NN
cord-034687-57n88v6t	26	20	in	in	IN
cord-034687-57n88v6t	26	21	the	the	DT
cord-034687-57n88v6t	26	22	control	control	NN
cord-034687-57n88v6t	26	23	of	of	IN
cord-034687-57n88v6t	26	24	emotional	emotional	JJ
cord-034687-57n88v6t	26	25	responses	response	NNS
cord-034687-57n88v6t	26	26	.	.	.
cord-034687-57n88v6t	27	1	4	4	LS
cord-034687-57n88v6t	28	1	Thus	thus	RB
cord-034687-57n88v6t	28	2	,	,	,
cord-034687-57n88v6t	28	3	cannabis	cannabis	NN
cord-034687-57n88v6t	28	4	users	user	NNS
cord-034687-57n88v6t	28	5	identify	identify	VBP
cord-034687-57n88v6t	28	6	a	a	DT
cord-034687-57n88v6t	28	7	subjective	subjective	JJ
cord-034687-57n88v6t	28	8	sensation	sensation	NN
cord-034687-57n88v6t	28	9	of	of	IN
cord-034687-57n88v6t	28	10	relaxation	relaxation	NN
cord-034687-57n88v6t	28	11	after	after	IN
cord-034687-57n88v6t	28	12	consumption	consumption	NN
cord-034687-57n88v6t	28	13	,	,	,
cord-034687-57n88v6t	28	14	which	which	WDT
cord-034687-57n88v6t	28	15	has	have	VBZ
cord-034687-57n88v6t	28	16	been	be	VBN
cord-034687-57n88v6t	28	17	linked	link	VBN
cord-034687-57n88v6t	28	18	Here	here	RB
cord-034687-57n88v6t	28	19	,	,	,
cord-034687-57n88v6t	28	20	we	-PRON-	PRP
cord-034687-57n88v6t	28	21	discuss	discuss	VBP
cord-034687-57n88v6t	28	22	recent	recent	JJ
cord-034687-57n88v6t	28	23	advances	advance	NNS
cord-034687-57n88v6t	28	24	in	in	IN
cord-034687-57n88v6t	28	25	the	the	DT
cord-034687-57n88v6t	28	26	role	role	NN
cord-034687-57n88v6t	28	27	of	of	IN
cord-034687-57n88v6t	28	28	the	the	DT
cord-034687-57n88v6t	28	29	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	28	30	system	system	NN
cord-034687-57n88v6t	28	31	in	in	IN
cord-034687-57n88v6t	28	32	determining	determine	VBG
cord-034687-57n88v6t	28	33	the	the	DT
cord-034687-57n88v6t	28	34	value	value	NN
cord-034687-57n88v6t	28	35	of	of	IN
cord-034687-57n88v6t	28	36	fearevoking	fearevoke	VBG
cord-034687-57n88v6t	28	37	stimuli	stimulus	NNS
cord-034687-57n88v6t	28	38	and	and	CC
cord-034687-57n88v6t	28	39	promoting	promote	VBG
cord-034687-57n88v6t	28	40	appropriate	appropriate	JJ
cord-034687-57n88v6t	28	41	behavioral	behavioral	JJ
cord-034687-57n88v6t	28	42	responses	response	NNS
cord-034687-57n88v6t	28	43	for	for	IN
cord-034687-57n88v6t	28	44	stress	stress	NN
cord-034687-57n88v6t	28	45	resilience	resilience	NN
cord-034687-57n88v6t	28	46	.	.	.
cord-034687-57n88v6t	29	1	We	-PRON-	PRP
cord-034687-57n88v6t	29	2	review	review	VBP
cord-034687-57n88v6t	29	3	the	the	DT
cord-034687-57n88v6t	29	4	alterations	alteration	NNS
cord-034687-57n88v6t	29	5	in	in	IN
cord-034687-57n88v6t	29	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	29	7	activity	activity	NN
cord-034687-57n88v6t	29	8	during	during	IN
cord-034687-57n88v6t	29	9	fear-	fear-	NN
cord-034687-57n88v6t	29	10	,	,	,
cord-034687-57n88v6t	29	11	stress-	stress-	NN
cord-034687-57n88v6t	29	12	,	,	,
cord-034687-57n88v6t	29	13	and	and	CC
cord-034687-57n88v6t	29	14	anxiety	anxiety	NN
cord-034687-57n88v6t	29	15	-	-	HYPH
cord-034687-57n88v6t	29	16	related	relate	VBN
cord-034687-57n88v6t	29	17	dysfunctions	dysfunction	NNS
cord-034687-57n88v6t	29	18	.	.	.
cord-034687-57n88v6t	30	1	Fear	fear	NN
cord-034687-57n88v6t	30	2	and	and	CC
cord-034687-57n88v6t	30	3	anxiety	anxiety	NN
cord-034687-57n88v6t	30	4	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	30	5	substrates	substrate	NNS
cord-034687-57n88v6t	30	6	mostly	mostly	RB
cord-034687-57n88v6t	30	7	overlap	overlap	VBP
cord-034687-57n88v6t	30	8	and	and	CC
cord-034687-57n88v6t	30	9	interact	interact	VB
cord-034687-57n88v6t	30	10	with	with	IN
cord-034687-57n88v6t	30	11	the	the	DT
cord-034687-57n88v6t	30	12	neurocircuitry	neurocircuitry	NN
cord-034687-57n88v6t	30	13	that	that	WDT
cord-034687-57n88v6t	30	14	governs	govern	VBZ
cord-034687-57n88v6t	30	15	the	the	DT
cord-034687-57n88v6t	30	16	stress	stress	NN
cord-034687-57n88v6t	30	17	response	response	NN
cord-034687-57n88v6t	30	18	.	.	.
cord-034687-57n88v6t	31	1	The	the	DT
cord-034687-57n88v6t	31	2	concept	concept	NN
cord-034687-57n88v6t	31	3	of	of	IN
cord-034687-57n88v6t	31	4	stress	stress	NN
cord-034687-57n88v6t	31	5	used	use	VBN
cord-034687-57n88v6t	31	6	in	in	IN
cord-034687-57n88v6t	31	7	this	this	DT
cord-034687-57n88v6t	31	8	review	review	NN
cord-034687-57n88v6t	31	9	will	will	MD
cord-034687-57n88v6t	31	10	be	be	VB
cord-034687-57n88v6t	31	11	specific	specific	JJ
cord-034687-57n88v6t	31	12	to	to	IN
cord-034687-57n88v6t	31	13	the	the	DT
cord-034687-57n88v6t	31	14	stress	stress	NN
cord-034687-57n88v6t	31	15	reaction	reaction	NN
cord-034687-57n88v6t	31	16	and	and	CC
cord-034687-57n88v6t	31	17	will	will	MD
cord-034687-57n88v6t	31	18	not	not	RB
cord-034687-57n88v6t	31	19	involve	involve	VB
cord-034687-57n88v6t	31	20	heterogeneous	heterogeneous	JJ
cord-034687-57n88v6t	31	21	concepts	concept	NNS
cord-034687-57n88v6t	31	22	such	such	JJ
cord-034687-57n88v6t	31	23	as	as	IN
cord-034687-57n88v6t	31	24	subjective	subjective	JJ
cord-034687-57n88v6t	31	25	distress	distress	NN
cord-034687-57n88v6t	31	26	.	.	.
cord-034687-57n88v6t	32	1	6	6	CD
cord-034687-57n88v6t	33	1	This	this	DT
cord-034687-57n88v6t	33	2	stress	stress	NN
cord-034687-57n88v6t	33	3	is	be	VBZ
cord-034687-57n88v6t	33	4	directly	directly	RB
cord-034687-57n88v6t	33	5	related	relate	VBN
cord-034687-57n88v6t	33	6	to	to	IN
cord-034687-57n88v6t	33	7	the	the	DT
cord-034687-57n88v6t	33	8	activation	activation	NN
cord-034687-57n88v6t	33	9	of	of	IN
cord-034687-57n88v6t	33	10	the	the	DT
cord-034687-57n88v6t	33	11	limbic	limbic	NNP
cord-034687-57n88v6t	33	12	-	-	HYPH
cord-034687-57n88v6t	33	13	HPA	HPA	NNP
cord-034687-57n88v6t	33	14	axis	axis	NN
cord-034687-57n88v6t	33	15	and	and	CC
cord-034687-57n88v6t	33	16	stress	stress	NN
cord-034687-57n88v6t	33	17	hormones	hormone	NNS
cord-034687-57n88v6t	33	18	such	such	JJ
cord-034687-57n88v6t	33	19	as	as	IN
cord-034687-57n88v6t	33	20	corticotropin	corticotropin	NNP
cord-034687-57n88v6t	33	21	-	-	HYPH
cord-034687-57n88v6t	33	22	releasing	release	VBG
cord-034687-57n88v6t	33	23	hormone	hormone	NN
cord-034687-57n88v6t	33	24	(	(	-LRB-
cord-034687-57n88v6t	33	25	CRH	CRH	NNP
cord-034687-57n88v6t	33	26	)	)	-RRB-
cord-034687-57n88v6t	33	27	,	,	,
cord-034687-57n88v6t	33	28	adrenocorticotropic	adrenocorticotropic	NNP
cord-034687-57n88v6t	33	29	hormone	hormone	NN
cord-034687-57n88v6t	33	30	(	(	-LRB-
cord-034687-57n88v6t	33	31	ACTH	ACTH	NNP
cord-034687-57n88v6t	33	32	)	)	-RRB-
cord-034687-57n88v6t	33	33	,	,	,
cord-034687-57n88v6t	33	34	and	and	CC
cord-034687-57n88v6t	33	35	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	33	36	,	,	,
cord-034687-57n88v6t	33	37	a	a	DT
cord-034687-57n88v6t	33	38	circuit	circuit	NN
cord-034687-57n88v6t	33	39	also	also	RB
cord-034687-57n88v6t	33	40	highly	highly	RB
cord-034687-57n88v6t	33	41	relevant	relevant	JJ
cord-034687-57n88v6t	33	42	for	for	IN
cord-034687-57n88v6t	33	43	fear	fear	NN
cord-034687-57n88v6t	33	44	and	and	CC
cord-034687-57n88v6t	33	45	anxiety	anxiety	NN
cord-034687-57n88v6t	33	46	.	.	.
cord-034687-57n88v6t	34	1	Links	link	NNS
cord-034687-57n88v6t	34	2	among	among	IN
cord-034687-57n88v6t	34	3	the	the	DT
cord-034687-57n88v6t	34	4	limbic	limbic	JJ
cord-034687-57n88v6t	34	5	system	system	NN
cord-034687-57n88v6t	34	6	,	,	,
cord-034687-57n88v6t	34	7	fear	fear	NN
cord-034687-57n88v6t	34	8	circuits	circuit	NNS
cord-034687-57n88v6t	34	9	,	,	,
cord-034687-57n88v6t	34	10	and	and	CC
cord-034687-57n88v6t	34	11	treatments	treatment	NNS
cord-034687-57n88v6t	34	12	for	for	IN
cord-034687-57n88v6t	34	13	worry	worry	NN
cord-034687-57n88v6t	34	14	and	and	CC
cord-034687-57n88v6t	34	15	fear	fear	NN
cord-034687-57n88v6t	34	16	across	across	IN
cord-034687-57n88v6t	34	17	the	the	DT
cord-034687-57n88v6t	34	18	spectrum	spectrum	NN
cord-034687-57n88v6t	34	19	of	of	IN
cord-034687-57n88v6t	34	20	anxiety	anxiety	NN
cord-034687-57n88v6t	34	21	disorders	disorder	NNS
cord-034687-57n88v6t	34	22	are	be	VBP
cord-034687-57n88v6t	34	23	discussed	discuss	VBN
cord-034687-57n88v6t	34	24	throughout	throughout	IN
cord-034687-57n88v6t	34	25	this	this	DT
cord-034687-57n88v6t	34	26	review	review	NN
cord-034687-57n88v6t	34	27	.	.	.
cord-034687-57n88v6t	35	1	Understanding	understand	VBG
cord-034687-57n88v6t	35	2	the	the	DT
cord-034687-57n88v6t	35	3	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	35	4	mechanisms	mechanism	NNS
cord-034687-57n88v6t	35	5	underlying	underlie	VBG
cord-034687-57n88v6t	35	6	resilience	resilience	NN
cord-034687-57n88v6t	35	7	versus	versus	IN
cord-034687-57n88v6t	35	8	vulnerability	vulnerability	NN
cord-034687-57n88v6t	35	9	to	to	TO
cord-034687-57n88v6t	35	10	develop	develop	VB
cord-034687-57n88v6t	35	11	anxiety	anxiety	NN
cord-034687-57n88v6t	35	12	disorders	disorder	NNS
cord-034687-57n88v6t	35	13	is	be	VBZ
cord-034687-57n88v6t	35	14	expected	expect	VBN
cord-034687-57n88v6t	35	15	to	to	TO
cord-034687-57n88v6t	35	16	open	open	VB
cord-034687-57n88v6t	35	17	novel	novel	JJ
cord-034687-57n88v6t	35	18	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	35	19	interventions	intervention	NNS
cord-034687-57n88v6t	35	20	to	to	TO
cord-034687-57n88v6t	35	21	battle	battle	VB
cord-034687-57n88v6t	35	22	these	these	DT
cord-034687-57n88v6t	35	23	disorders	disorder	NNS
cord-034687-57n88v6t	35	24	.	.	.
cord-034687-57n88v6t	36	1	Fear	fear	NN
cord-034687-57n88v6t	36	2	is	be	VBZ
cord-034687-57n88v6t	36	3	the	the	DT
cord-034687-57n88v6t	36	4	emotional	emotional	JJ
cord-034687-57n88v6t	36	5	response	response	NN
cord-034687-57n88v6t	36	6	to	to	IN
cord-034687-57n88v6t	36	7	real	real	JJ
cord-034687-57n88v6t	36	8	or	or	CC
cord-034687-57n88v6t	36	9	perceived	perceive	VBN
cord-034687-57n88v6t	36	10	imminent	imminent	JJ
cord-034687-57n88v6t	36	11	threats	threat	NNS
cord-034687-57n88v6t	36	12	,	,	,
cord-034687-57n88v6t	36	13	whereas	whereas	IN
cord-034687-57n88v6t	36	14	anxiety	anxiety	NN
cord-034687-57n88v6t	36	15	is	be	VBZ
cord-034687-57n88v6t	36	16	the	the	DT
cord-034687-57n88v6t	36	17	anticipation	anticipation	NN
cord-034687-57n88v6t	36	18	of	of	IN
cord-034687-57n88v6t	36	19	future	future	JJ
cord-034687-57n88v6t	36	20	threat	threat	NN
cord-034687-57n88v6t	36	21	.	.	.
cord-034687-57n88v6t	37	1	Fear	fear	NN
cord-034687-57n88v6t	37	2	is	be	VBZ
cord-034687-57n88v6t	37	3	a	a	DT
cord-034687-57n88v6t	37	4	normal	normal	JJ
cord-034687-57n88v6t	37	5	emotion	emotion	NN
cord-034687-57n88v6t	37	6	when	when	WRB
cord-034687-57n88v6t	37	7	it	-PRON-	PRP
cord-034687-57n88v6t	37	8	appears	appear	VBZ
cord-034687-57n88v6t	37	9	under	under	IN
cord-034687-57n88v6t	37	10	a	a	DT
cord-034687-57n88v6t	37	11	context	context	NN
cord-034687-57n88v6t	37	12	of	of	IN
cord-034687-57n88v6t	37	13	the	the	DT
cord-034687-57n88v6t	37	14	threat	threat	NN
cord-034687-57n88v6t	37	15	,	,	,
cord-034687-57n88v6t	37	16	and	and	CC
cord-034687-57n88v6t	37	17	it	-PRON-	PRP
cord-034687-57n88v6t	37	18	is	be	VBZ
cord-034687-57n88v6t	37	19	considered	consider	VBN
cord-034687-57n88v6t	37	20	an	an	DT
cord-034687-57n88v6t	37	21	important	important	JJ
cord-034687-57n88v6t	37	22	part	part	NN
cord-034687-57n88v6t	37	23	of	of	IN
cord-034687-57n88v6t	37	24	the	the	DT
cord-034687-57n88v6t	37	25	evolutionary	evolutionary	JJ
cord-034687-57n88v6t	37	26	reaction	reaction	NN
cord-034687-57n88v6t	37	27	of	of	IN
cord-034687-57n88v6t	37	28	survival	survival	NN
cord-034687-57n88v6t	37	29	that	that	WDT
cord-034687-57n88v6t	37	30	prepares	prepare	VBZ
cord-034687-57n88v6t	37	31	Figure	figure	NN
cord-034687-57n88v6t	37	32	1	1	CD
cord-034687-57n88v6t	37	33	.	.	.
cord-034687-57n88v6t	38	1	Overview	overview	NN
cord-034687-57n88v6t	38	2	of	of	IN
cord-034687-57n88v6t	38	3	the	the	DT
cord-034687-57n88v6t	38	4	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	38	5	-	-	HYPH
cord-034687-57n88v6t	38	6	mediated	mediate	VBN
cord-034687-57n88v6t	38	7	synaptic	synaptic	JJ
cord-034687-57n88v6t	38	8	signaling	signal	VBG
cord-034687-57n88v6t	38	9	at	at	IN
cord-034687-57n88v6t	38	10	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	38	11	terminals	terminal	NNS
cord-034687-57n88v6t	38	12	.	.	.
cord-034687-57n88v6t	39	1	The	the	DT
cord-034687-57n88v6t	39	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	39	3	system	system	NN
cord-034687-57n88v6t	39	4	is	be	VBZ
cord-034687-57n88v6t	39	5	a	a	DT
cord-034687-57n88v6t	39	6	retrograde	retrograde	JJ
cord-034687-57n88v6t	39	7	neuromodulator	neuromodulator	NN
cord-034687-57n88v6t	39	8	.	.	.
cord-034687-57n88v6t	40	1	After	after	IN
cord-034687-57n88v6t	40	2	neuronal	neuronal	JJ
cord-034687-57n88v6t	40	3	depolarization	depolarization	NN
cord-034687-57n88v6t	40	4	at	at	IN
cord-034687-57n88v6t	40	5	the	the	DT
cord-034687-57n88v6t	40	6	postsynaptic	postsynaptic	JJ
cord-034687-57n88v6t	40	7	level	level	NN
cord-034687-57n88v6t	40	8	,	,	,
cord-034687-57n88v6t	40	9	the	the	DT
cord-034687-57n88v6t	40	10	endocannabinoids	endocannabinoid	NNS
cord-034687-57n88v6t	40	11	are	be	VBP
cord-034687-57n88v6t	40	12	synthesized	synthesize	VBN
cord-034687-57n88v6t	40	13	on	on	IN
cord-034687-57n88v6t	40	14	demand	demand	NN
cord-034687-57n88v6t	40	15	and	and	CC
cord-034687-57n88v6t	40	16	travel	travel	NN
cord-034687-57n88v6t	40	17	backwards	backwards	RB
cord-034687-57n88v6t	40	18	to	to	TO
cord-034687-57n88v6t	40	19	bind	bind	VB
cord-034687-57n88v6t	40	20	the	the	DT
cord-034687-57n88v6t	40	21	presynaptic	presynaptic	JJ
cord-034687-57n88v6t	40	22	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	40	23	1	1	CD
cord-034687-57n88v6t	40	24	receptor	receptor	NN
cord-034687-57n88v6t	40	25	(	(	-LRB-
cord-034687-57n88v6t	40	26	CB	CB	NNP
cord-034687-57n88v6t	40	27	1	1	CD
cord-034687-57n88v6t	40	28	R	r	NN
cord-034687-57n88v6t	40	29	)	)	-RRB-
cord-034687-57n88v6t	40	30	.	.	.
cord-034687-57n88v6t	41	1	Through	through	IN
cord-034687-57n88v6t	41	2	this	this	DT
cord-034687-57n88v6t	41	3	synaptic	synaptic	JJ
cord-034687-57n88v6t	41	4	mechanism	mechanism	NN
cord-034687-57n88v6t	41	5	,	,	,
cord-034687-57n88v6t	41	6	the	the	DT
cord-034687-57n88v6t	41	7	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	41	8	system	system	NN
cord-034687-57n88v6t	41	9	controls	control	VBZ
cord-034687-57n88v6t	41	10	different	different	JJ
cord-034687-57n88v6t	41	11	pathophysiological	pathophysiological	JJ
cord-034687-57n88v6t	41	12	processes	process	NNS
cord-034687-57n88v6t	41	13	including	include	VBG
cord-034687-57n88v6t	41	14	fear	fear	NN
cord-034687-57n88v6t	41	15	,	,	,
cord-034687-57n88v6t	41	16	stress	stress	NN
cord-034687-57n88v6t	41	17	,	,	,
cord-034687-57n88v6t	41	18	and	and	CC
cord-034687-57n88v6t	41	19	anxiety	anxiety	NN
cord-034687-57n88v6t	41	20	.	.	.
cord-034687-57n88v6t	42	1	In	in	IN
cord-034687-57n88v6t	42	2	detail	detail	NN
cord-034687-57n88v6t	42	3	,	,	,
cord-034687-57n88v6t	42	4	glutamate	glutamate	NN
cord-034687-57n88v6t	42	5	released	release	VBN
cord-034687-57n88v6t	42	6	from	from	IN
cord-034687-57n88v6t	42	7	presynaptic	presynaptic	JJ
cord-034687-57n88v6t	42	8	terminals	terminal	NNS
cord-034687-57n88v6t	42	9	stimulates	stimulate	VBZ
cord-034687-57n88v6t	42	10	both	both	DT
cord-034687-57n88v6t	42	11	ionotropic	ionotropic	JJ
cord-034687-57n88v6t	42	12	and	and	CC
cord-034687-57n88v6t	42	13	metabotropic	metabotropic	JJ
cord-034687-57n88v6t	42	14	glutamate	glutamate	NN
cord-034687-57n88v6t	42	15	receptors	receptor	NNS
cord-034687-57n88v6t	42	16	,	,	,
cord-034687-57n88v6t	42	17	such	such	JJ
cord-034687-57n88v6t	42	18	as	as	IN
cord-034687-57n88v6t	42	19	N	n	CD
cord-034687-57n88v6t	42	20	-	-	HYPH
cord-034687-57n88v6t	42	21	methyl	methyl	NN
cord-034687-57n88v6t	42	22	-	-	HYPH
cord-034687-57n88v6t	42	23	D	d	NN
cord-034687-57n88v6t	42	24	-	-	HYPH
cord-034687-57n88v6t	42	25	aspartate	aspartate	NN
cord-034687-57n88v6t	42	26	(	(	-LRB-
cord-034687-57n88v6t	42	27	NMDA	NMDA	NNP
cord-034687-57n88v6t	42	28	)	)	-RRB-
cord-034687-57n88v6t	42	29	and	and	CC
cord-034687-57n88v6t	42	30	metabotropic	metabotropic	NNP
cord-034687-57n88v6t	42	31	glutamate	glutamate	NN
cord-034687-57n88v6t	42	32	receptor	receptor	NN
cord-034687-57n88v6t	42	33	1	1	CD
cord-034687-57n88v6t	42	34	and	and	CC
cord-034687-57n88v6t	42	35	5	5	CD
cord-034687-57n88v6t	42	36	(	(	-LRB-
cord-034687-57n88v6t	42	37	mGluR1/5	mGluR1/5	NNP
cord-034687-57n88v6t	42	38	)	)	-RRB-
cord-034687-57n88v6t	42	39	receptors	receptor	NNS
cord-034687-57n88v6t	42	40	,	,	,
cord-034687-57n88v6t	42	41	leading	lead	VBG
cord-034687-57n88v6t	42	42	to	to	IN
cord-034687-57n88v6t	42	43	postsynaptic	postsynaptic	JJ
cord-034687-57n88v6t	42	44	depolarization	depolarization	NN
cord-034687-57n88v6t	42	45	through	through	IN
cord-034687-57n88v6t	42	46	Ca	Ca	NNP
cord-034687-57n88v6t	42	47	2	2	CD
cord-034687-57n88v6t	42	48	+	+	CC
cord-034687-57n88v6t	42	49	entry	entry	NN
cord-034687-57n88v6t	42	50	and	and	CC
cord-034687-57n88v6t	42	51	Gq	Gq	NNP
cord-034687-57n88v6t	42	52	-	-	HYPH
cord-034687-57n88v6t	42	53	protein	protein	NN
cord-034687-57n88v6t	42	54	activation	activation	NN
cord-034687-57n88v6t	42	55	.	.	.
cord-034687-57n88v6t	43	1	Increased	increase	VBN
cord-034687-57n88v6t	43	2	intracellular	intracellular	JJ
cord-034687-57n88v6t	44	1	Ca	ca	NN
cord-034687-57n88v6t	44	2	2	2	CD
cord-034687-57n88v6t	44	3	+	+	CC
cord-034687-57n88v6t	44	4	concentration	concentration	NN
cord-034687-57n88v6t	44	5	stimulates	stimulate	VBZ
cord-034687-57n88v6t	44	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	44	7	synthesis	synthesis	NN
cord-034687-57n88v6t	44	8	through	through	IN
cord-034687-57n88v6t	44	9	phospholipase	phospholipase	NN
cord-034687-57n88v6t	44	10	C	C	NNP
cord-034687-57n88v6t	44	11	(	(	-LRB-
cord-034687-57n88v6t	44	12	2-arachidonoylglycerol	2-arachidonoylglycerol	CD
cord-034687-57n88v6t	44	13	,	,	,
cord-034687-57n88v6t	44	14	2-AG	2-ag	CD
cord-034687-57n88v6t	44	15	)	)	-RRB-
cord-034687-57n88v6t	44	16	and	and	CC
cord-034687-57n88v6t	44	17	phospholipase	phospholipase	NN
cord-034687-57n88v6t	44	18	D	d	NN
cord-034687-57n88v6t	44	19	(	(	-LRB-
cord-034687-57n88v6t	44	20	anandamide	anandamide	NN
cord-034687-57n88v6t	44	21	,	,	,
cord-034687-57n88v6t	44	22	AEA	AEA	NNP
cord-034687-57n88v6t	44	23	)	)	-RRB-
cord-034687-57n88v6t	44	24	.	.	.
cord-034687-57n88v6t	45	1	2-AG	2-ag	CD
cord-034687-57n88v6t	45	2	synthesis	synthesis	NN
cord-034687-57n88v6t	45	3	is	be	VBZ
cord-034687-57n88v6t	45	4	also	also	RB
cord-034687-57n88v6t	45	5	mediated	mediate	VBN
cord-034687-57n88v6t	45	6	by	by	IN
cord-034687-57n88v6t	45	7	Gq	Gq	NNP
cord-034687-57n88v6t	45	8	-	-	HYPH
cord-034687-57n88v6t	45	9	protein	protein	NN
cord-034687-57n88v6t	45	10	activation	activation	NN
cord-034687-57n88v6t	45	11	.	.	.
cord-034687-57n88v6t	46	1	Endocannabinoids	endocannabinoid	NNS
cord-034687-57n88v6t	46	2	are	be	VBP
cord-034687-57n88v6t	46	3	released	release	VBN
cord-034687-57n88v6t	46	4	to	to	IN
cord-034687-57n88v6t	46	5	the	the	DT
cord-034687-57n88v6t	46	6	synaptic	synaptic	JJ
cord-034687-57n88v6t	46	7	cleft	cleft	NN
cord-034687-57n88v6t	46	8	and	and	CC
cord-034687-57n88v6t	46	9	activate	activate	VB
cord-034687-57n88v6t	46	10	presynaptic	presynaptic	JJ
cord-034687-57n88v6t	46	11	CB	CB	NNP
cord-034687-57n88v6t	46	12	1	1	CD
cord-034687-57n88v6t	46	13	R.	R.	NNP
cord-034687-57n88v6t	46	14	CB	CB	NNP
cord-034687-57n88v6t	46	15	1	1	CD
cord-034687-57n88v6t	46	16	R	r	NN
cord-034687-57n88v6t	46	17	activation	activation	NN
cord-034687-57n88v6t	46	18	by	by	IN
cord-034687-57n88v6t	46	19	the	the	DT
cord-034687-57n88v6t	46	20	endocannabinoids	endocannabinoids	NNP
cord-034687-57n88v6t	46	21	AEA	AEA	NNP
cord-034687-57n88v6t	46	22	and	and	CC
cord-034687-57n88v6t	46	23	2-AG	2-ag	CD
cord-034687-57n88v6t	46	24	triggers	trigger	VBZ
cord-034687-57n88v6t	46	25	several	several	JJ
cord-034687-57n88v6t	46	26	intracellular	intracellular	JJ
cord-034687-57n88v6t	46	27	pathways	pathway	NNS
cord-034687-57n88v6t	46	28	via	via	IN
cord-034687-57n88v6t	46	29	Gi	Gi	NNP
cord-034687-57n88v6t	46	30	/	/	SYM
cord-034687-57n88v6t	46	31	o	o	NN
cord-034687-57n88v6t	46	32	proteins	protein	NNS
cord-034687-57n88v6t	46	33	,	,	,
cord-034687-57n88v6t	46	34	including	include	VBG
cord-034687-57n88v6t	46	35	inhibition	inhibition	NN
cord-034687-57n88v6t	46	36	of	of	IN
cord-034687-57n88v6t	46	37	adenylate	adenylate	NN
cord-034687-57n88v6t	46	38	cyclase	cyclase	NN
cord-034687-57n88v6t	46	39	(	(	-LRB-
cord-034687-57n88v6t	46	40	AC	ac	NN
cord-034687-57n88v6t	46	41	)	)	-RRB-
cord-034687-57n88v6t	46	42	activity	activity	NN
cord-034687-57n88v6t	46	43	,	,	,
cord-034687-57n88v6t	46	44	membrane	membrane	NN
cord-034687-57n88v6t	46	45	hyperpolarization	hyperpolarization	NN
cord-034687-57n88v6t	46	46	through	through	IN
cord-034687-57n88v6t	46	47	activation	activation	NN
cord-034687-57n88v6t	46	48	of	of	IN
cord-034687-57n88v6t	46	49	K	K	NNP
cord-034687-57n88v6t	46	50	+	+	CC
cord-034687-57n88v6t	46	51	channel	channel	NN
cord-034687-57n88v6t	46	52	currents	current	NNS
cord-034687-57n88v6t	46	53	and	and	CC
cord-034687-57n88v6t	46	54	blockage	blockage	NN
cord-034687-57n88v6t	46	55	of	of	IN
cord-034687-57n88v6t	46	56	Ca	Ca	NNP
cord-034687-57n88v6t	46	57	2	2	CD
cord-034687-57n88v6t	46	58	+	+	CC
cord-034687-57n88v6t	46	59	voltage	voltage	NN
cord-034687-57n88v6t	46	60	-	-	HYPH
cord-034687-57n88v6t	46	61	dependent	dependent	JJ
cord-034687-57n88v6t	46	62	channels	channel	NNS
cord-034687-57n88v6t	46	63	,	,	,
cord-034687-57n88v6t	46	64	which	which	WDT
cord-034687-57n88v6t	46	65	results	result	VBZ
cord-034687-57n88v6t	46	66	in	in	IN
cord-034687-57n88v6t	46	67	the	the	DT
cord-034687-57n88v6t	46	68	inhibition	inhibition	NN
cord-034687-57n88v6t	46	69	of	of	IN
cord-034687-57n88v6t	46	70	glutamate	glutamate	NN
cord-034687-57n88v6t	46	71	release	release	NN
cord-034687-57n88v6t	46	72	.	.	.
cord-034687-57n88v6t	47	1	Abbreviations	abbreviation	NNS
cord-034687-57n88v6t	47	2	:	:	:
cord-034687-57n88v6t	47	3	2-AG	2-ag	CD
cord-034687-57n88v6t	47	4	,	,	,
cord-034687-57n88v6t	47	5	2-arachidonoylglycerol	2-arachidonoylglycerol	CD
cord-034687-57n88v6t	47	6	;	;	:
cord-034687-57n88v6t	47	7	AC	AC	NNP
cord-034687-57n88v6t	47	8	,	,	,
cord-034687-57n88v6t	47	9	adenylate	adenylate	NN
cord-034687-57n88v6t	47	10	cyclase	cyclase	NN
cord-034687-57n88v6t	47	11	;	;	:
cord-034687-57n88v6t	47	12	AEA	AEA	NNP
cord-034687-57n88v6t	47	13	,	,	,
cord-034687-57n88v6t	47	14	anandamide	anandamide	NN
cord-034687-57n88v6t	47	15	;	;	:
cord-034687-57n88v6t	47	16	CB	CB	NNP
cord-034687-57n88v6t	47	17	1	1	CD
cord-034687-57n88v6t	47	18	,	,	,
cord-034687-57n88v6t	47	19	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	47	20	1	1	CD
cord-034687-57n88v6t	47	21	receptor	receptor	NN
cord-034687-57n88v6t	47	22	;	;	:
cord-034687-57n88v6t	47	23	DAG	DAG	NNP
cord-034687-57n88v6t	47	24	,	,	,
cord-034687-57n88v6t	47	25	diacylglycerol	diacylglycerol	NN
cord-034687-57n88v6t	47	26	;	;	:
cord-034687-57n88v6t	47	27	DAGLα	DAGLα	NNS
cord-034687-57n88v6t	47	28	,	,	,
cord-034687-57n88v6t	47	29	diacyl	diacyl	JJ
cord-034687-57n88v6t	47	30	glycerol	glycerol	NN
cord-034687-57n88v6t	47	31	lipase	lipase	NN
cord-034687-57n88v6t	47	32	α	α	NNP
cord-034687-57n88v6t	47	33	;	;	:
cord-034687-57n88v6t	47	34	mGluR1/5	mGluR1/5	NNP
cord-034687-57n88v6t	47	35	;	;	,
cord-034687-57n88v6t	47	36	metabotropic	metabotropic	NNP
cord-034687-57n88v6t	47	37	glutamate	glutamate	NN
cord-034687-57n88v6t	47	38	receptor	receptor	NN
cord-034687-57n88v6t	47	39	1	1	CD
cord-034687-57n88v6t	47	40	and	and	CC
cord-034687-57n88v6t	47	41	5	5	CD
cord-034687-57n88v6t	47	42	;	;	:
cord-034687-57n88v6t	47	43	NAPE	NAPE	NNP
cord-034687-57n88v6t	47	44	,	,	,
cord-034687-57n88v6t	47	45	N	N	NNP
cord-034687-57n88v6t	47	46	-	-	HYPH
cord-034687-57n88v6t	47	47	arachidonoyl	arachidonoyl	NNP
cord-034687-57n88v6t	47	48	-	-	HYPH
cord-034687-57n88v6t	47	49	phosphatidyl	phosphatidyl	NN
cord-034687-57n88v6t	47	50	ethanol	ethanol	NN
cord-034687-57n88v6t	47	51	amine	amine	NN
cord-034687-57n88v6t	47	52	;	;	:
cord-034687-57n88v6t	47	53	NMDA	NMDA	NNP
cord-034687-57n88v6t	47	54	,	,	,
cord-034687-57n88v6t	47	55	N	n	CD
cord-034687-57n88v6t	47	56	-	-	HYPH
cord-034687-57n88v6t	47	57	methyl	methyl	NN
cord-034687-57n88v6t	47	58	-	-	HYPH
cord-034687-57n88v6t	47	59	D	d	NN
cord-034687-57n88v6t	47	60	-	-	HYPH
cord-034687-57n88v6t	47	61	aspartate	aspartate	NN
cord-034687-57n88v6t	47	62	;	;	:
cord-034687-57n88v6t	47	63	PLC	PLC	NNP
cord-034687-57n88v6t	47	64	,	,	,
cord-034687-57n88v6t	47	65	phospholipase	phospholipase	NN
cord-034687-57n88v6t	47	66	C	C	NNP
cord-034687-57n88v6t	47	67	;	;	:
cord-034687-57n88v6t	47	68	PLD	PLD	NNP
cord-034687-57n88v6t	47	69	,	,	,
cord-034687-57n88v6t	47	70	phospholipase	phospholipase	NN
cord-034687-57n88v6t	47	71	D	d	NN
cord-034687-57n88v6t	47	72	;	;	:
cord-034687-57n88v6t	47	73	PIP2	PIP2	NNP
cord-034687-57n88v6t	47	74	,	,	,
cord-034687-57n88v6t	47	75	phosphatidyl	phosphatidyl	NNP
cord-034687-57n88v6t	47	76	inositol	inositol	NN
cord-034687-57n88v6t	47	77	bisphosphate	bisphosphate	NNP
cord-034687-57n88v6t	47	78	to	to	TO
cord-034687-57n88v6t	47	79	fight	fight	VB
cord-034687-57n88v6t	47	80	or	or	CC
cord-034687-57n88v6t	47	81	escape	escape	VB
cord-034687-57n88v6t	47	82	.	.	.
cord-034687-57n88v6t	48	1	Appropriate	appropriate	JJ
cord-034687-57n88v6t	48	2	fear	fear	NN
cord-034687-57n88v6t	48	3	responses	response	NNS
cord-034687-57n88v6t	48	4	are	be	VBP
cord-034687-57n88v6t	48	5	adaptive	adaptive	JJ
cord-034687-57n88v6t	48	6	and	and	CC
cord-034687-57n88v6t	48	7	allow	allow	VB
cord-034687-57n88v6t	48	8	the	the	DT
cord-034687-57n88v6t	48	9	individual	individual	NN
cord-034687-57n88v6t	48	10	to	to	TO
cord-034687-57n88v6t	48	11	cope	cope	VB
cord-034687-57n88v6t	48	12	with	with	IN
cord-034687-57n88v6t	48	13	dangerous	dangerous	JJ
cord-034687-57n88v6t	48	14	or	or	CC
cord-034687-57n88v6t	48	15	stressful	stressful	JJ
cord-034687-57n88v6t	48	16	situations	situation	NNS
cord-034687-57n88v6t	48	17	,	,	,
cord-034687-57n88v6t	48	18	but	but	CC
cord-034687-57n88v6t	48	19	exaggerated	exaggerated	JJ
cord-034687-57n88v6t	48	20	fear	fear	NN
cord-034687-57n88v6t	48	21	responses	response	NNS
cord-034687-57n88v6t	48	22	can	can	MD
cord-034687-57n88v6t	48	23	lead	lead	VB
cord-034687-57n88v6t	48	24	to	to	IN
cord-034687-57n88v6t	48	25	anxiety	anxiety	NN
cord-034687-57n88v6t	48	26	disorders	disorder	NNS
cord-034687-57n88v6t	48	27	.	.	.
cord-034687-57n88v6t	48	28	2	2	CD
cord-034687-57n88v6t	49	1	Although	although	IN
cord-034687-57n88v6t	49	2	fear	fear	NN
cord-034687-57n88v6t	49	3	and	and	CC
cord-034687-57n88v6t	49	4	anxiety	anxiety	NN
cord-034687-57n88v6t	49	5	can	can	MD
cord-034687-57n88v6t	49	6	overlap	overlap	VB
cord-034687-57n88v6t	49	7	,	,	,
cord-034687-57n88v6t	49	8	they	-PRON-	PRP
cord-034687-57n88v6t	49	9	also	also	RB
cord-034687-57n88v6t	49	10	differ	differ	VBP
cord-034687-57n88v6t	49	11	.	.	.
cord-034687-57n88v6t	50	1	Thus	thus	RB
cord-034687-57n88v6t	50	2	,	,	,
cord-034687-57n88v6t	50	3	fear	fear	NN
cord-034687-57n88v6t	50	4	is	be	VBZ
cord-034687-57n88v6t	50	5	often	often	RB
cord-034687-57n88v6t	50	6	associated	associate	VBN
cord-034687-57n88v6t	50	7	with	with	IN
cord-034687-57n88v6t	50	8	surges	surge	NNS
cord-034687-57n88v6t	50	9	of	of	IN
cord-034687-57n88v6t	50	10	autonomic	autonomic	JJ
cord-034687-57n88v6t	50	11	arousal	arousal	NN
cord-034687-57n88v6t	50	12	necessary	necessary	JJ
cord-034687-57n88v6t	50	13	for	for	IN
cord-034687-57n88v6t	50	14	a	a	DT
cord-034687-57n88v6t	50	15	fight	fight	NN
cord-034687-57n88v6t	50	16	,	,	,
cord-034687-57n88v6t	50	17	thoughts	thought	NNS
cord-034687-57n88v6t	50	18	of	of	IN
cord-034687-57n88v6t	50	19	immediate	immediate	JJ
cord-034687-57n88v6t	50	20	danger	danger	NN
cord-034687-57n88v6t	50	21	,	,	,
cord-034687-57n88v6t	50	22	and	and	CC
cord-034687-57n88v6t	50	23	escape	escape	VB
cord-034687-57n88v6t	50	24	behaviors	behavior	NNS
cord-034687-57n88v6t	50	25	,	,	,
cord-034687-57n88v6t	50	26	whereas	whereas	IN
cord-034687-57n88v6t	50	27	anxiety	anxiety	NN
cord-034687-57n88v6t	50	28	is	be	VBZ
cord-034687-57n88v6t	50	29	more	more	RBR
cord-034687-57n88v6t	50	30	often	often	RB
cord-034687-57n88v6t	50	31	associated	associate	VBN
cord-034687-57n88v6t	50	32	with	with	IN
cord-034687-57n88v6t	50	33	muscle	muscle	NN
cord-034687-57n88v6t	50	34	tension	tension	NN
cord-034687-57n88v6t	50	35	and	and	CC
cord-034687-57n88v6t	50	36	caution	caution	NN
cord-034687-57n88v6t	50	37	in	in	IN
cord-034687-57n88v6t	50	38	preparation	preparation	NN
cord-034687-57n88v6t	50	39	for	for	IN
cord-034687-57n88v6t	50	40	future	future	JJ
cord-034687-57n88v6t	50	41	danger	danger	NN
cord-034687-57n88v6t	50	42	and	and	CC
cord-034687-57n88v6t	50	43	with	with	IN
cord-034687-57n88v6t	50	44	alert	alert	NN
cord-034687-57n88v6t	50	45	or	or	CC
cord-034687-57n88v6t	50	46	avoidance	avoidance	NN
cord-034687-57n88v6t	50	47	behaviors	behavior	NNS
cord-034687-57n88v6t	50	48	.	.	.
cord-034687-57n88v6t	51	1	7	7	CD
cord-034687-57n88v6t	52	1	The	the	DT
cord-034687-57n88v6t	52	2	amygdala	amygdala	NN
cord-034687-57n88v6t	52	3	is	be	VBZ
cord-034687-57n88v6t	52	4	a	a	DT
cord-034687-57n88v6t	52	5	limbic	limbic	JJ
cord-034687-57n88v6t	52	6	hub	hub	NN
cord-034687-57n88v6t	52	7	of	of	IN
cord-034687-57n88v6t	52	8	communications	communication	NNS
cord-034687-57n88v6t	52	9	crucial	crucial	JJ
cord-034687-57n88v6t	52	10	for	for	IN
cord-034687-57n88v6t	52	11	fear	fear	NN
cord-034687-57n88v6t	52	12	behavior	behavior	NN
cord-034687-57n88v6t	52	13	owing	owe	VBG
cord-034687-57n88v6t	52	14	to	to	IN
cord-034687-57n88v6t	52	15	its	-PRON-	PRP$
cord-034687-57n88v6t	52	16	anatomical	anatomical	JJ
cord-034687-57n88v6t	52	17	connections	connection	NNS
cord-034687-57n88v6t	52	18	integrating	integrate	VBG
cord-034687-57n88v6t	52	19	sensory	sensory	JJ
cord-034687-57n88v6t	52	20	and	and	CC
cord-034687-57n88v6t	52	21	cognitive	cognitive	JJ
cord-034687-57n88v6t	52	22	information	information	NN
cord-034687-57n88v6t	52	23	(	(	-LRB-
cord-034687-57n88v6t	52	24	Figure	figure	NN
cord-034687-57n88v6t	52	25	2	2	CD
cord-034687-57n88v6t	52	26	)	)	-RRB-
cord-034687-57n88v6t	52	27	.	.	.
cord-034687-57n88v6t	53	1	The	the	DT
cord-034687-57n88v6t	53	2	emotion	emotion	NN
cord-034687-57n88v6t	53	3	of	of	IN
cord-034687-57n88v6t	53	4	fear	fear	NN
cord-034687-57n88v6t	53	5	may	may	MD
cord-034687-57n88v6t	53	6	be	be	VB
cord-034687-57n88v6t	53	7	controlled	control	VBN
cord-034687-57n88v6t	53	8	through	through	IN
cord-034687-57n88v6t	53	9	reciprocal	reciprocal	JJ
cord-034687-57n88v6t	53	10	networks	network	NNS
cord-034687-57n88v6t	53	11	with	with	IN
cord-034687-57n88v6t	53	12	key	key	JJ
cord-034687-57n88v6t	53	13	areas	area	NNS
cord-034687-57n88v6t	53	14	of	of	IN
cord-034687-57n88v6t	53	15	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	53	16	cortex	cortex	NNP
cord-034687-57n88v6t	53	17	(	(	-LRB-
cord-034687-57n88v6t	53	18	PFC	PFC	NNP
cord-034687-57n88v6t	53	19	)	)	-RRB-
cord-034687-57n88v6t	53	20	.	.	.
cord-034687-57n88v6t	54	1	Motor	motor	NN
cord-034687-57n88v6t	54	2	responses	response	NNS
cord-034687-57n88v6t	54	3	of	of	IN
cord-034687-57n88v6t	54	4	fear	fear	NN
cord-034687-57n88v6t	54	5	,	,	,
cord-034687-57n88v6t	54	6	mainly	mainly	RB
cord-034687-57n88v6t	54	7	fighting	fight	VBG
cord-034687-57n88v6t	54	8	and	and	CC
cord-034687-57n88v6t	54	9	escape	escape	NN
cord-034687-57n88v6t	54	10	,	,	,
cord-034687-57n88v6t	54	11	are	be	VBP
cord-034687-57n88v6t	54	12	regulated	regulate	VBN
cord-034687-57n88v6t	54	13	by	by	IN
cord-034687-57n88v6t	54	14	connections	connection	NNS
cord-034687-57n88v6t	54	15	between	between	IN
cord-034687-57n88v6t	54	16	the	the	DT
cord-034687-57n88v6t	54	17	amygdala	amygdala	NNP
cord-034687-57n88v6t	54	18	and	and	CC
cord-034687-57n88v6t	54	19	periaqueductal	periaqueductal	NNP
cord-034687-57n88v6t	54	20	gray	gray	NN
cord-034687-57n88v6t	54	21	.	.	.
cord-034687-57n88v6t	55	1	Endocrine	endocrine	JJ
cord-034687-57n88v6t	55	2	responses	response	NNS
cord-034687-57n88v6t	55	3	that	that	WDT
cord-034687-57n88v6t	55	4	complement	complement	VBP
cord-034687-57n88v6t	55	5	fear	fear	NN
cord-034687-57n88v6t	55	6	are	be	VBP
cord-034687-57n88v6t	55	7	mainly	mainly	RB
cord-034687-57n88v6t	55	8	mediated	mediate	VBN
cord-034687-57n88v6t	55	9	by	by	IN
cord-034687-57n88v6t	55	10	connections	connection	NNS
cord-034687-57n88v6t	55	11	between	between	IN
cord-034687-57n88v6t	55	12	amygdala	amygdala	NN
cord-034687-57n88v6t	55	13	and	and	CC
cord-034687-57n88v6t	55	14	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	55	15	,	,	,
cord-034687-57n88v6t	55	16	leading	lead	VBG
cord-034687-57n88v6t	55	17	to	to	IN
cord-034687-57n88v6t	55	18	changes	change	NNS
cord-034687-57n88v6t	55	19	in	in	IN
cord-034687-57n88v6t	55	20	the	the	DT
cord-034687-57n88v6t	55	21	HPA	HPA	NNP
cord-034687-57n88v6t	55	22	axis	axis	NN
cord-034687-57n88v6t	55	23	.	.	.
cord-034687-57n88v6t	56	1	7	7	CD
cord-034687-57n88v6t	57	1	The	the	DT
cord-034687-57n88v6t	57	2	autonomic	autonomic	JJ
cord-034687-57n88v6t	57	3	nervous	nervous	JJ
cord-034687-57n88v6t	57	4	system	system	NN
cord-034687-57n88v6t	57	5	is	be	VBZ
cord-034687-57n88v6t	57	6	also	also	RB
cord-034687-57n88v6t	57	7	stimulated	stimulate	VBN
cord-034687-57n88v6t	57	8	in	in	IN
cord-034687-57n88v6t	57	9	response	response	NN
cord-034687-57n88v6t	57	10	to	to	IN
cord-034687-57n88v6t	57	11	fearful	fearful	JJ
cord-034687-57n88v6t	57	12	stimuli	stimulus	NNS
cord-034687-57n88v6t	57	13	,	,	,
cord-034687-57n88v6t	57	14	activating	activate	VBG
cord-034687-57n88v6t	57	15	the	the	DT
cord-034687-57n88v6t	57	16	cardiovascular	cardiovascular	JJ
cord-034687-57n88v6t	57	17	system	system	NN
cord-034687-57n88v6t	57	18	(	(	-LRB-
cord-034687-57n88v6t	57	19	enhanced	enhance	VBN
cord-034687-57n88v6t	57	20	blood	blood	NN
cord-034687-57n88v6t	57	21	pressure	pressure	NN
cord-034687-57n88v6t	57	22	and	and	CC
cord-034687-57n88v6t	57	23	heart	heart	NN
cord-034687-57n88v6t	57	24	rate	rate	NN
cord-034687-57n88v6t	57	25	)	)	-RRB-
cord-034687-57n88v6t	57	26	through	through	IN
cord-034687-57n88v6t	57	27	increased	increase	VBN
cord-034687-57n88v6t	57	28	connectivity	connectivity	NN
cord-034687-57n88v6t	57	29	between	between	IN
cord-034687-57n88v6t	57	30	amygdala	amygdala	NN
cord-034687-57n88v6t	57	31	and	and	CC
cord-034687-57n88v6t	57	32	locus	locus	NN
cord-034687-57n88v6t	57	33	ceruleus	ceruleus	NNP
cord-034687-57n88v6t	57	34	,	,	,
cord-034687-57n88v6t	57	35	the	the	DT
cord-034687-57n88v6t	57	36	major	major	JJ
cord-034687-57n88v6t	57	37	source	source	NN
cord-034687-57n88v6t	57	38	of	of	IN
cord-034687-57n88v6t	57	39	brain	brain	NN
cord-034687-57n88v6t	57	40	noradrenergic	noradrenergic	JJ
cord-034687-57n88v6t	57	41	innervation	innervation	NN
cord-034687-57n88v6t	57	42	.	.	.
cord-034687-57n88v6t	58	1	8	8	CD
cord-034687-57n88v6t	59	1	Fear	fear	NN
cord-034687-57n88v6t	59	2	and	and	CC
cord-034687-57n88v6t	59	3	anxiety	anxiety	NN
cord-034687-57n88v6t	59	4	disorders	disorder	NNS
cord-034687-57n88v6t	59	5	can	can	MD
cord-034687-57n88v6t	59	6	also	also	RB
cord-034687-57n88v6t	59	7	be	be	VB
cord-034687-57n88v6t	59	8	elicited	elicit	VBN
cord-034687-57n88v6t	59	9	internally	internally	RB
cord-034687-57n88v6t	59	10	from	from	IN
cord-034687-57n88v6t	59	11	traumatic	traumatic	JJ
cord-034687-57n88v6t	59	12	memories	memory	NNS
cord-034687-57n88v6t	59	13	stored	store	VBN
cord-034687-57n88v6t	59	14	in	in	IN
cord-034687-57n88v6t	59	15	the	the	DT
cord-034687-57n88v6t	59	16	hippocampus	hippocampus	NN
cord-034687-57n88v6t	59	17	and	and	CC
cord-034687-57n88v6t	59	18	reactivated	reactivate	VBN
cord-034687-57n88v6t	59	19	by	by	IN
cord-034687-57n88v6t	59	20	the	the	DT
cord-034687-57n88v6t	59	21	amygdala	amygdala	NN
cord-034687-57n88v6t	59	22	.	.	.
cord-034687-57n88v6t	60	1	In	in	IN
cord-034687-57n88v6t	60	2	posttraumatic	posttraumatic	JJ
cord-034687-57n88v6t	60	3	stress	stress	NN
cord-034687-57n88v6t	60	4	disorder	disorder	NN
cord-034687-57n88v6t	60	5	(	(	-LRB-
cord-034687-57n88v6t	60	6	PTSD	PTSD	NNP
cord-034687-57n88v6t	60	7	)	)	-RRB-
cord-034687-57n88v6t	60	8	,	,	,
cord-034687-57n88v6t	60	9	persistent	persistent	JJ
cord-034687-57n88v6t	60	10	,	,	,
cord-034687-57n88v6t	60	11	recurring	recur	VBG
cord-034687-57n88v6t	60	12	memories	memory	NNS
cord-034687-57n88v6t	60	13	of	of	IN
cord-034687-57n88v6t	60	14	traumatic	traumatic	JJ
cord-034687-57n88v6t	60	15	events	event	NNS
cord-034687-57n88v6t	60	16	occur	occur	VBP
cord-034687-57n88v6t	60	17	,	,	,
cord-034687-57n88v6t	60	18	which	which	WDT
cord-034687-57n88v6t	60	19	the	the	DT
cord-034687-57n88v6t	60	20	individual	individual	NN
cord-034687-57n88v6t	60	21	is	be	VBZ
cord-034687-57n88v6t	60	22	unable	unable	JJ
cord-034687-57n88v6t	60	23	to	to	TO
cord-034687-57n88v6t	60	24	extinguish	extinguish	VB
cord-034687-57n88v6t	60	25	.	.	.
cord-034687-57n88v6t	61	1	3	3	CD
cord-034687-57n88v6t	61	2	Extinction	extinction	NN
cord-034687-57n88v6t	61	3	plays	play	VBZ
cord-034687-57n88v6t	61	4	a	a	DT
cord-034687-57n88v6t	61	5	crucial	crucial	JJ
cord-034687-57n88v6t	61	6	role	role	NN
cord-034687-57n88v6t	61	7	and	and	CC
cord-034687-57n88v6t	61	8	is	be	VBZ
cord-034687-57n88v6t	61	9	considered	consider	VBN
cord-034687-57n88v6t	61	10	an	an	DT
cord-034687-57n88v6t	61	11	active	active	JJ
cord-034687-57n88v6t	61	12	associative	associative	NN
cord-034687-57n88v6t	61	13	-	-	HYPH
cord-034687-57n88v6t	61	14	learning	learning	NN
cord-034687-57n88v6t	61	15	process	process	NN
cord-034687-57n88v6t	61	16	.	.	.
cord-034687-57n88v6t	62	1	9	9	CD
cord-034687-57n88v6t	63	1	In	in	IN
cord-034687-57n88v6t	63	2	normal	normal	JJ
cord-034687-57n88v6t	63	3	conditions	condition	NNS
cord-034687-57n88v6t	63	4	,	,	,
cord-034687-57n88v6t	63	5	natural	natural	JJ
cord-034687-57n88v6t	63	6	stimuli	stimulus	NNS
cord-034687-57n88v6t	63	7	that	that	WDT
cord-034687-57n88v6t	63	8	signal	signal	VBP
cord-034687-57n88v6t	63	9	threat	threat	NN
cord-034687-57n88v6t	63	10	provoke	provoke	VB
cord-034687-57n88v6t	63	11	an	an	DT
cord-034687-57n88v6t	63	12	innate	innate	JJ
cord-034687-57n88v6t	63	13	fear	fear	NN
cord-034687-57n88v6t	63	14	response	response	NN
cord-034687-57n88v6t	63	15	.	.	.
cord-034687-57n88v6t	64	1	This	this	DT
cord-034687-57n88v6t	64	2	response	response	NN
cord-034687-57n88v6t	64	3	is	be	VBZ
cord-034687-57n88v6t	64	4	used	use	VBN
cord-034687-57n88v6t	64	5	in	in	IN
cord-034687-57n88v6t	64	6	the	the	DT
cord-034687-57n88v6t	64	7	fear	fear	NN
cord-034687-57n88v6t	64	8	conditioning	conditioning	NN
cord-034687-57n88v6t	64	9	paradigm	paradigm	NN
cord-034687-57n88v6t	64	10	to	to	TO
cord-034687-57n88v6t	64	11	study	study	VB
cord-034687-57n88v6t	64	12	fear	fear	NN
cord-034687-57n88v6t	64	13	-	-	HYPH
cord-034687-57n88v6t	64	14	based	base	VBN
cord-034687-57n88v6t	64	15	disorders	disorder	NNS
cord-034687-57n88v6t	64	16	based	base	VBN
cord-034687-57n88v6t	64	17	on	on	IN
cord-034687-57n88v6t	64	18	Pavlovian	pavlovian	JJ
cord-034687-57n88v6t	64	19	conditioning	conditioning	NN
cord-034687-57n88v6t	64	20	.	.	.
cord-034687-57n88v6t	65	1	Such	such	PDT
cord-034687-57n88v6t	65	2	an	an	DT
cord-034687-57n88v6t	65	3	associative	associative	JJ
cord-034687-57n88v6t	65	4	learning	learning	NN
cord-034687-57n88v6t	65	5	process	process	NN
cord-034687-57n88v6t	65	6	consists	consist	VBZ
cord-034687-57n88v6t	65	7	of	of	IN
cord-034687-57n88v6t	65	8	pairing	pair	VBG
cord-034687-57n88v6t	65	9	a	a	DT
cord-034687-57n88v6t	65	10	neutral	neutral	JJ
cord-034687-57n88v6t	65	11	conditioned	condition	VBN
cord-034687-57n88v6t	65	12	stimulus	stimulus	NN
cord-034687-57n88v6t	65	13	(	(	-LRB-
cord-034687-57n88v6t	65	14	CS	CS	NNP
cord-034687-57n88v6t	65	15	)	)	-RRB-
cord-034687-57n88v6t	65	16	with	with	IN
cord-034687-57n88v6t	65	17	an	an	DT
cord-034687-57n88v6t	65	18	aversive	aversive	JJ
cord-034687-57n88v6t	65	19	unconditioned	unconditioned	JJ
cord-034687-57n88v6t	65	20	stimulus	stimulus	NN
cord-034687-57n88v6t	65	21	(	(	-LRB-
cord-034687-57n88v6t	65	22	US	US	NNP
cord-034687-57n88v6t	65	23	)	)	-RRB-
cord-034687-57n88v6t	65	24	that	that	WDT
cord-034687-57n88v6t	65	25	produces	produce	VBZ
cord-034687-57n88v6t	65	26	a	a	DT
cord-034687-57n88v6t	65	27	conditioned	condition	VBN
cord-034687-57n88v6t	65	28	fear	fear	NN
cord-034687-57n88v6t	65	29	response	response	NN
cord-034687-57n88v6t	65	30	(	(	-LRB-
cord-034687-57n88v6t	65	31	freezing	freeze	VBG
cord-034687-57n88v6t	65	32	in	in	IN
cord-034687-57n88v6t	65	33	rodents	rodent	NNS
cord-034687-57n88v6t	65	34	,	,	,
cord-034687-57n88v6t	65	35	skin	skin	NN
cord-034687-57n88v6t	65	36	conductance	conductance	NN
cord-034687-57n88v6t	65	37	response	response	NN
cord-034687-57n88v6t	65	38	in	in	IN
cord-034687-57n88v6t	65	39	humans	human	NNS
cord-034687-57n88v6t	65	40	)	)	-RRB-
cord-034687-57n88v6t	65	41	.	.	.
cord-034687-57n88v6t	66	1	In	in	IN
cord-034687-57n88v6t	66	2	PTSD	PTSD	NNP
cord-034687-57n88v6t	66	3	patients	patient	NNS
cord-034687-57n88v6t	66	4	,	,	,
cord-034687-57n88v6t	66	5	fear	fear	NN
cord-034687-57n88v6t	66	6	learning	learning	NN
cord-034687-57n88v6t	66	7	,	,	,
cord-034687-57n88v6t	66	8	specifically	specifically	RB
cord-034687-57n88v6t	66	9	extinction	extinction	NN
cord-034687-57n88v6t	66	10	,	,	,
cord-034687-57n88v6t	66	11	is	be	VBZ
cord-034687-57n88v6t	66	12	thought	think	VBN
cord-034687-57n88v6t	66	13	to	to	TO
cord-034687-57n88v6t	66	14	be	be	VB
cord-034687-57n88v6t	66	15	impaired	impair	VBN
cord-034687-57n88v6t	66	16	.	.	.
cord-034687-57n88v6t	67	1	Animal	animal	NN
cord-034687-57n88v6t	67	2	models	model	NNS
cord-034687-57n88v6t	67	3	of	of	IN
cord-034687-57n88v6t	67	4	pathological	pathological	JJ
cord-034687-57n88v6t	67	5	fear	fear	NN
cord-034687-57n88v6t	67	6	learning	learn	VBG
cord-034687-57n88v6t	67	7	are	be	VBP
cord-034687-57n88v6t	67	8	essential	essential	JJ
cord-034687-57n88v6t	67	9	to	to	TO
cord-034687-57n88v6t	67	10	find	find	VB
cord-034687-57n88v6t	67	11	effective	effective	JJ
cord-034687-57n88v6t	67	12	treatments	treatment	NNS
cord-034687-57n88v6t	67	13	for	for	IN
cord-034687-57n88v6t	67	14	such	such	JJ
cord-034687-57n88v6t	67	15	disorders	disorder	NNS
cord-034687-57n88v6t	67	16	.	.	.
cord-034687-57n88v6t	68	1	In	in	IN
cord-034687-57n88v6t	68	2	this	this	DT
cord-034687-57n88v6t	68	3	context	context	NN
cord-034687-57n88v6t	68	4	,	,	,
cord-034687-57n88v6t	68	5	the	the	DT
cord-034687-57n88v6t	68	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	68	7	system	system	NN
cord-034687-57n88v6t	68	8	plays	play	VBZ
cord-034687-57n88v6t	68	9	figure	figure	NN
cord-034687-57n88v6t	68	10	:	:	:
cord-034687-57n88v6t	68	11	an	an	DT
cord-034687-57n88v6t	68	12	overview	overview	NN
cord-034687-57n88v6t	68	13	of	of	IN
cord-034687-57n88v6t	68	14	this	this	DT
cord-034687-57n88v6t	68	15	interconnected	interconnect	VBN
cord-034687-57n88v6t	68	16	circuit	circuit	NN
cord-034687-57n88v6t	68	17	is	be	VBZ
cord-034687-57n88v6t	68	18	represented	represent	VBN
cord-034687-57n88v6t	68	19	in	in	IN
cord-034687-57n88v6t	68	20	the	the	DT
cord-034687-57n88v6t	68	21	human	human	JJ
cord-034687-57n88v6t	68	22	brain	brain	NN
cord-034687-57n88v6t	68	23	.	.	.
cord-034687-57n88v6t	69	1	The	the	DT
cord-034687-57n88v6t	69	2	amygdala	amygdala	NN
cord-034687-57n88v6t	69	3	has	have	VBZ
cord-034687-57n88v6t	69	4	bilateral	bilateral	JJ
cord-034687-57n88v6t	69	5	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	69	6	interconnections	interconnection	NNS
cord-034687-57n88v6t	69	7	with	with	IN
cord-034687-57n88v6t	69	8	the	the	DT
cord-034687-57n88v6t	69	9	prefrontal	prefrontal	NNP
cord-034687-57n88v6t	69	10	cortex	cortex	NNP
cord-034687-57n88v6t	69	11	and	and	CC
cord-034687-57n88v6t	69	12	the	the	DT
cord-034687-57n88v6t	69	13	hippocampus	hippocampus	NN
cord-034687-57n88v6t	69	14	to	to	TO
cord-034687-57n88v6t	69	15	associate	associate	VB
cord-034687-57n88v6t	69	16	emotional	emotional	JJ
cord-034687-57n88v6t	69	17	,	,	,
cord-034687-57n88v6t	69	18	cognitive	cognitive	JJ
cord-034687-57n88v6t	69	19	,	,	,
cord-034687-57n88v6t	69	20	and	and	CC
cord-034687-57n88v6t	69	21	executive	executive	JJ
cord-034687-57n88v6t	69	22	functions	function	NNS
cord-034687-57n88v6t	69	23	.	.	.
cord-034687-57n88v6t	70	1	The	the	DT
cord-034687-57n88v6t	70	2	amygdala	amygdala	NN
cord-034687-57n88v6t	70	3	controls	control	VBZ
cord-034687-57n88v6t	70	4	the	the	DT
cord-034687-57n88v6t	70	5	activity	activity	NN
cord-034687-57n88v6t	70	6	of	of	IN
cord-034687-57n88v6t	70	7	midbrain	midbrain	NN
cord-034687-57n88v6t	70	8	,	,	,
cord-034687-57n88v6t	70	9	brainstem	brainstem	NN
cord-034687-57n88v6t	70	10	nuclei	nucleus	NNS
cord-034687-57n88v6t	70	11	,	,	,
cord-034687-57n88v6t	70	12	and	and	CC
cord-034687-57n88v6t	70	13	neuroendocrine	neuroendocrine	JJ
cord-034687-57n88v6t	70	14	areas	area	NNS
cord-034687-57n88v6t	70	15	(	(	-LRB-
cord-034687-57n88v6t	70	16	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	70	17	and	and	CC
cord-034687-57n88v6t	70	18	pituitary	pituitary	JJ
cord-034687-57n88v6t	70	19	anterior	anterior	NNP
cord-034687-57n88v6t	70	20	)	)	-RRB-
cord-034687-57n88v6t	70	21	through	through	IN
cord-034687-57n88v6t	70	22	GABAergic	gabaergic	JJ
cord-034687-57n88v6t	70	23	projections	projection	NNS
cord-034687-57n88v6t	70	24	that	that	WDT
cord-034687-57n88v6t	70	25	mediate	mediate	VBP
cord-034687-57n88v6t	70	26	emotional	emotional	JJ
cord-034687-57n88v6t	70	27	,	,	,
cord-034687-57n88v6t	70	28	motor	motor	NN
cord-034687-57n88v6t	70	29	,	,	,
cord-034687-57n88v6t	70	30	and	and	CC
cord-034687-57n88v6t	70	31	neuroendocrine	neuroendocrine	JJ
cord-034687-57n88v6t	70	32	responses	response	NNS
cord-034687-57n88v6t	70	33	to	to	TO
cord-034687-57n88v6t	70	34	fear	fear	VB
cord-034687-57n88v6t	70	35	,	,	,
cord-034687-57n88v6t	70	36	stress	stress	NN
cord-034687-57n88v6t	70	37	,	,	,
cord-034687-57n88v6t	70	38	and	and	CC
cord-034687-57n88v6t	70	39	anxiety	anxiety	NN
cord-034687-57n88v6t	70	40	.	.	.
cord-034687-57n88v6t	71	1	Right	right	JJ
cord-034687-57n88v6t	71	2	figure	figure	NN
cord-034687-57n88v6t	71	3	:	:	:
cord-034687-57n88v6t	71	4	precise	precise	JJ
cord-034687-57n88v6t	71	5	modulation	modulation	NN
cord-034687-57n88v6t	71	6	of	of	IN
cord-034687-57n88v6t	71	7	fear	fear	NN
cord-034687-57n88v6t	71	8	expression	expression	NN
cord-034687-57n88v6t	71	9	by	by	IN
cord-034687-57n88v6t	71	10	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	71	11	signaling	signaling	NN
cord-034687-57n88v6t	71	12	in	in	IN
cord-034687-57n88v6t	71	13	the	the	DT
cord-034687-57n88v6t	71	14	same	same	JJ
cord-034687-57n88v6t	71	15	circuit	circuit	NN
cord-034687-57n88v6t	71	16	targeting	target	VBG
cord-034687-57n88v6t	71	17	the	the	DT
cord-034687-57n88v6t	71	18	amygdala	amygdala	NN
cord-034687-57n88v6t	71	19	is	be	VBZ
cord-034687-57n88v6t	71	20	represented	represent	VBN
cord-034687-57n88v6t	71	21	in	in	IN
cord-034687-57n88v6t	71	22	the	the	DT
cord-034687-57n88v6t	71	23	rodent	rodent	NN
cord-034687-57n88v6t	71	24	brain	brain	NN
cord-034687-57n88v6t	71	25	at	at	IN
cord-034687-57n88v6t	71	26	the	the	DT
cord-034687-57n88v6t	71	27	bottom	bottom	JJ
cord-034687-57n88v6t	71	28	right	right	JJ
cord-034687-57n88v6t	71	29	panel	panel	NN
cord-034687-57n88v6t	71	30	.	.	.
cord-034687-57n88v6t	72	1	In	in	IN
cord-034687-57n88v6t	72	2	detail	detail	NN
cord-034687-57n88v6t	72	3	,	,	,
cord-034687-57n88v6t	72	4	the	the	DT
cord-034687-57n88v6t	72	5	role	role	NN
cord-034687-57n88v6t	72	6	of	of	IN
cord-034687-57n88v6t	72	7	the	the	DT
cord-034687-57n88v6t	72	8	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	72	9	1	1	CD
cord-034687-57n88v6t	72	10	receptor	receptor	NN
cord-034687-57n88v6t	72	11	(	(	-LRB-
cord-034687-57n88v6t	72	12	CB	CB	NNP
cord-034687-57n88v6t	72	13	1	1	CD
cord-034687-57n88v6t	72	14	R	r	NN
cord-034687-57n88v6t	72	15	)	)	-RRB-
cord-034687-57n88v6t	72	16	depends	depend	VBZ
cord-034687-57n88v6t	72	17	on	on	IN
cord-034687-57n88v6t	72	18	the	the	DT
cord-034687-57n88v6t	72	19	specific	specific	JJ
cord-034687-57n88v6t	72	20	cell	cell	NN
cord-034687-57n88v6t	72	21	type	type	NN
cord-034687-57n88v6t	72	22	and	and	CC
cord-034687-57n88v6t	72	23	brain	brain	NN
cord-034687-57n88v6t	72	24	region	region	NN
cord-034687-57n88v6t	72	25	where	where	WRB
cord-034687-57n88v6t	72	26	they	-PRON-	PRP
cord-034687-57n88v6t	72	27	are	be	VBP
cord-034687-57n88v6t	72	28	expressed	express	VBN
cord-034687-57n88v6t	72	29	.	.	.
cord-034687-57n88v6t	73	1	On	on	IN
cord-034687-57n88v6t	73	2	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	73	3	neurons	neuron	NNS
cord-034687-57n88v6t	73	4	,	,	,
cord-034687-57n88v6t	73	5	activation	activation	NN
cord-034687-57n88v6t	73	6	of	of	IN
cord-034687-57n88v6t	73	7	CB	CB	NNP
cord-034687-57n88v6t	73	8	1	1	CD
cord-034687-57n88v6t	73	9	R	r	NN
cord-034687-57n88v6t	73	10	leads	lead	VBZ
cord-034687-57n88v6t	73	11	to	to	IN
cord-034687-57n88v6t	73	12	a	a	DT
cord-034687-57n88v6t	73	13	decrease	decrease	NN
cord-034687-57n88v6t	73	14	in	in	IN
cord-034687-57n88v6t	73	15	active	active	JJ
cord-034687-57n88v6t	73	16	coping	cope	VBG
cord-034687-57n88v6t	73	17	strategies	strategy	NNS
cord-034687-57n88v6t	73	18	in	in	IN
cord-034687-57n88v6t	73	19	the	the	DT
cord-034687-57n88v6t	73	20	fear	fear	NN
cord-034687-57n88v6t	73	21	conditioning	conditioning	NN
cord-034687-57n88v6t	73	22	paradigm	paradigm	NN
cord-034687-57n88v6t	73	23	,	,	,
cord-034687-57n88v6t	73	24	which	which	WDT
cord-034687-57n88v6t	73	25	may	may	MD
cord-034687-57n88v6t	73	26	facilitate	facilitate	VB
cord-034687-57n88v6t	73	27	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	73	28	-	-	HYPH
cord-034687-57n88v6t	73	29	like	like	JJ
cord-034687-57n88v6t	73	30	responses	response	NNS
cord-034687-57n88v6t	73	31	,	,	,
cord-034687-57n88v6t	73	32	possibly	possibly	RB
cord-034687-57n88v6t	73	33	due	due	IN
cord-034687-57n88v6t	73	34	to	to	IN
cord-034687-57n88v6t	73	35	a	a	DT
cord-034687-57n88v6t	73	36	decreased	decrease	VBN
cord-034687-57n88v6t	73	37	activity	activity	NN
cord-034687-57n88v6t	73	38	of	of	IN
cord-034687-57n88v6t	73	39	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	73	40	interneurons	interneuron	NNS
cord-034687-57n88v6t	73	41	in	in	IN
cord-034687-57n88v6t	73	42	the	the	DT
cord-034687-57n88v6t	73	43	basolateral	basolateral	JJ
cord-034687-57n88v6t	73	44	amygdala	amygdala	NN
cord-034687-57n88v6t	73	45	that	that	WDT
cord-034687-57n88v6t	73	46	produces	produce	VBZ
cord-034687-57n88v6t	73	47	an	an	DT
cord-034687-57n88v6t	73	48	activation	activation	NN
cord-034687-57n88v6t	73	49	of	of	IN
cord-034687-57n88v6t	73	50	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	73	51	neurons	neuron	NNS
cord-034687-57n88v6t	73	52	projecting	project	VBG
cord-034687-57n88v6t	73	53	to	to	IN
cord-034687-57n88v6t	73	54	the	the	DT
cord-034687-57n88v6t	73	55	central	central	JJ
cord-034687-57n88v6t	73	56	amygdala	amygdala	NN
cord-034687-57n88v6t	73	57	,	,	,
cord-034687-57n88v6t	73	58	which	which	WDT
cord-034687-57n88v6t	73	59	results	result	VBZ
cord-034687-57n88v6t	73	60	in	in	IN
cord-034687-57n88v6t	73	61	enhanced	enhanced	JJ
cord-034687-57n88v6t	73	62	activity	activity	NN
cord-034687-57n88v6t	73	63	of	of	IN
cord-034687-57n88v6t	73	64	the	the	DT
cord-034687-57n88v6t	73	65	central	central	JJ
cord-034687-57n88v6t	73	66	amygdala	amygdala	NN
cord-034687-57n88v6t	73	67	.	.	.
cord-034687-57n88v6t	74	1	Conversely	conversely	RB
cord-034687-57n88v6t	74	2	,	,	,
cord-034687-57n88v6t	74	3	the	the	DT
cord-034687-57n88v6t	74	4	activation	activation	NN
cord-034687-57n88v6t	74	5	of	of	IN
cord-034687-57n88v6t	74	6	CB1R	CB1R	NNP
cord-034687-57n88v6t	74	7	on	on	IN
cord-034687-57n88v6t	74	8	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	74	9	terminals	terminal	NNS
cord-034687-57n88v6t	74	10	in	in	IN
cord-034687-57n88v6t	74	11	the	the	DT
cord-034687-57n88v6t	74	12	central	central	JJ
cord-034687-57n88v6t	74	13	amygdala	amygdala	NN
cord-034687-57n88v6t	74	14	induces	induce	VBZ
cord-034687-57n88v6t	74	15	a	a	DT
cord-034687-57n88v6t	74	16	decrease	decrease	NN
cord-034687-57n88v6t	74	17	in	in	IN
cord-034687-57n88v6t	74	18	passive	passive	JJ
cord-034687-57n88v6t	74	19	coping	cope	VBG
cord-034687-57n88v6t	74	20	strategies	strategy	NNS
cord-034687-57n88v6t	74	21	in	in	IN
cord-034687-57n88v6t	74	22	the	the	DT
cord-034687-57n88v6t	74	23	fear	fear	NN
cord-034687-57n88v6t	74	24	conditioning	conditioning	NN
cord-034687-57n88v6t	74	25	paradigm	paradigm	NN
cord-034687-57n88v6t	74	26	facilitating	facilitate	VBG
cord-034687-57n88v6t	74	27	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	74	28	-	-	HYPH
cord-034687-57n88v6t	74	29	like	like	JJ
cord-034687-57n88v6t	74	30	responses	response	NNS
cord-034687-57n88v6t	74	31	,	,	,
cord-034687-57n88v6t	74	32	possibly	possibly	RB
cord-034687-57n88v6t	74	33	due	due	JJ
cord-034687-57n88v6t	74	34	to	to	IN
cord-034687-57n88v6t	74	35	attenuated	attenuate	VBN
cord-034687-57n88v6t	74	36	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	74	37	excitation	excitation	NN
cord-034687-57n88v6t	74	38	from	from	IN
cord-034687-57n88v6t	74	39	the	the	DT
cord-034687-57n88v6t	74	40	basolateral	basolateral	JJ
cord-034687-57n88v6t	74	41	amygdala	amygdala	NN
cord-034687-57n88v6t	74	42	,	,	,
cord-034687-57n88v6t	74	43	which	which	WDT
cord-034687-57n88v6t	74	44	results	result	VBZ
cord-034687-57n88v6t	74	45	in	in	IN
cord-034687-57n88v6t	74	46	a	a	DT
cord-034687-57n88v6t	74	47	decreased	decreased	JJ
cord-034687-57n88v6t	74	48	activation	activation	NN
cord-034687-57n88v6t	74	49	of	of	IN
cord-034687-57n88v6t	74	50	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	74	51	neurons	neuron	NNS
cord-034687-57n88v6t	74	52	in	in	IN
cord-034687-57n88v6t	74	53	the	the	DT
cord-034687-57n88v6t	74	54	central	central	JJ
cord-034687-57n88v6t	74	55	amygdala	amygdala	NN
cord-034687-57n88v6t	74	56	that	that	WDT
cord-034687-57n88v6t	74	57	project	project	VBP
cord-034687-57n88v6t	74	58	to	to	IN
cord-034687-57n88v6t	74	59	the	the	DT
cord-034687-57n88v6t	74	60	midbrain	midbrain	NN
cord-034687-57n88v6t	74	61	and	and	CC
cord-034687-57n88v6t	74	62	other	other	JJ
cord-034687-57n88v6t	74	63	brainstem	brainstem	NN
cord-034687-57n88v6t	74	64	nuclei	nucleus	NNS
cord-034687-57n88v6t	74	65	.	.	.
cord-034687-57n88v6t	75	1	These	these	DT
cord-034687-57n88v6t	75	2	results	result	NNS
cord-034687-57n88v6t	75	3	point	point	VBP
cord-034687-57n88v6t	75	4	to	to	IN
cord-034687-57n88v6t	75	5	a	a	DT
cord-034687-57n88v6t	75	6	supposed	supposed	JJ
cord-034687-57n88v6t	75	7	bimodal	bimodal	JJ
cord-034687-57n88v6t	75	8	control	control	NN
cord-034687-57n88v6t	75	9	of	of	IN
cord-034687-57n88v6t	75	10	fear	fear	NN
cord-034687-57n88v6t	75	11	expression	expression	NN
cord-034687-57n88v6t	75	12	by	by	IN
cord-034687-57n88v6t	75	13	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	75	14	signaling	signaling	NN
cord-034687-57n88v6t	75	15	in	in	IN
cord-034687-57n88v6t	75	16	amygdala	amygdala	NN
cord-034687-57n88v6t	75	17	-	-	HYPH
cord-034687-57n88v6t	75	18	dependent	dependent	JJ
cord-034687-57n88v6t	75	19	circuits	circuit	NNS
cord-034687-57n88v6t	75	20	that	that	WDT
cord-034687-57n88v6t	75	21	can	can	MD
cord-034687-57n88v6t	75	22	also	also	RB
cord-034687-57n88v6t	75	23	be	be	VB
cord-034687-57n88v6t	75	24	modulated	modulate	VBN
cord-034687-57n88v6t	75	25	by	by	IN
cord-034687-57n88v6t	75	26	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	75	27	inputs	input	NNS
cord-034687-57n88v6t	75	28	from	from	IN
cord-034687-57n88v6t	75	29	the	the	DT
cord-034687-57n88v6t	75	30	prefrontal	prefrontal	NNP
cord-034687-57n88v6t	75	31	cortex	cortex	NNP
cord-034687-57n88v6t	75	32	and	and	CC
cord-034687-57n88v6t	75	33	the	the	DT
cord-034687-57n88v6t	75	34	hippocampus	hippocampus	NN
cord-034687-57n88v6t	75	35	.	.	.
cord-034687-57n88v6t	76	1	Abbreviations	abbreviation	NNS
cord-034687-57n88v6t	76	2	:	:	:
cord-034687-57n88v6t	76	3	BLA	BLA	NNP
cord-034687-57n88v6t	76	4	,	,	,
cord-034687-57n88v6t	76	5	basolateral	basolateral	JJ
cord-034687-57n88v6t	76	6	amígdala	amígdala	NNP
cord-034687-57n88v6t	76	7	;	;	:
cord-034687-57n88v6t	76	8	CB	CB	NNP
cord-034687-57n88v6t	76	9	1	1	CD
cord-034687-57n88v6t	76	10	R	r	NN
cord-034687-57n88v6t	76	11	,	,	,
cord-034687-57n88v6t	76	12	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	76	13	1	1	CD
cord-034687-57n88v6t	76	14	receptor	receptor	NN
cord-034687-57n88v6t	76	15	;	;	:
cord-034687-57n88v6t	76	16	CeA	CeA	NNP
cord-034687-57n88v6t	76	17	,	,	,
cord-034687-57n88v6t	76	18	central	central	JJ
cord-034687-57n88v6t	76	19	amygdala	amygdala	NN
cord-034687-57n88v6t	76	20	;	;	:
cord-034687-57n88v6t	76	21	PFC	PFC	NNP
cord-034687-57n88v6t	76	22	,	,	,
cord-034687-57n88v6t	76	23	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	76	24	cortex	cortex	NN
cord-034687-57n88v6t	77	1	The	the	DT
cord-034687-57n88v6t	77	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	77	3	system	system	NN
cord-034687-57n88v6t	77	4	in	in	IN
cord-034687-57n88v6t	77	5	fear	fear	NN
cord-034687-57n88v6t	77	6	,	,	,
cord-034687-57n88v6t	77	7	anxiety	anxiety	NN
cord-034687-57n88v6t	77	8	,	,	,
cord-034687-57n88v6t	77	9	and	and	CC
cord-034687-57n88v6t	77	10	stress	stress	NN
cord-034687-57n88v6t	77	11	-Maldonado	-Maldonado	.
cord-034687-57n88v6t	78	1	et	et	NNP
cord-034687-57n88v6t	78	2	al	al	NNP
cord-034687-57n88v6t	78	3	a	a	DT
cord-034687-57n88v6t	78	4	crucial	crucial	JJ
cord-034687-57n88v6t	78	5	role	role	NN
cord-034687-57n88v6t	78	6	in	in	IN
cord-034687-57n88v6t	78	7	fear	fear	NN
cord-034687-57n88v6t	78	8	-	-	HYPH
cord-034687-57n88v6t	78	9	related	relate	VBN
cord-034687-57n88v6t	78	10	brain	brain	NN
cord-034687-57n88v6t	78	11	circuits	circuit	NNS
cord-034687-57n88v6t	78	12	and	and	CC
cord-034687-57n88v6t	78	13	is	be	VBZ
cord-034687-57n88v6t	78	14	crucially	crucially	RB
cord-034687-57n88v6t	78	15	involved	involve	VBN
cord-034687-57n88v6t	78	16	in	in	IN
cord-034687-57n88v6t	78	17	the	the	DT
cord-034687-57n88v6t	78	18	modulation	modulation	NN
cord-034687-57n88v6t	78	19	of	of	IN
cord-034687-57n88v6t	78	20	fear	fear	NN
cord-034687-57n88v6t	78	21	-	-	HYPH
cord-034687-57n88v6t	78	22	memory	memory	NN
cord-034687-57n88v6t	78	23	processing	processing	NN
cord-034687-57n88v6t	78	24	.	.	.
cord-034687-57n88v6t	79	1	8	8	CD
cord-034687-57n88v6t	80	1	The	the	DT
cord-034687-57n88v6t	80	2	role	role	NN
cord-034687-57n88v6t	80	3	of	of	IN
cord-034687-57n88v6t	80	4	the	the	DT
cord-034687-57n88v6t	80	5	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	80	6	system	system	NN
cord-034687-57n88v6t	80	7	in	in	IN
cord-034687-57n88v6t	80	8	modulating	modulate	VBG
cord-034687-57n88v6t	80	9	the	the	DT
cord-034687-57n88v6t	80	10	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	80	11	mechanisms	mechanism	NNS
cord-034687-57n88v6t	80	12	involved	involve	VBN
cord-034687-57n88v6t	80	13	in	in	IN
cord-034687-57n88v6t	80	14	fear	fear	NN
cord-034687-57n88v6t	80	15	behavior	behavior	NN
cord-034687-57n88v6t	80	16	has	have	VBZ
cord-034687-57n88v6t	80	17	been	be	VBN
cord-034687-57n88v6t	80	18	widely	widely	RB
cord-034687-57n88v6t	80	19	investigated	investigate	VBN
cord-034687-57n88v6t	80	20	.	.	.
cord-034687-57n88v6t	81	1	9	9	CD
cord-034687-57n88v6t	81	2	Two	two	CD
cord-034687-57n88v6t	81	3	neuronal	neuronal	JJ
cord-034687-57n88v6t	81	4	populations	population	NNS
cord-034687-57n88v6t	81	5	expressing	express	VBG
cord-034687-57n88v6t	81	6	CB	CB	NNP
cord-034687-57n88v6t	81	7	1	1	CD
cord-034687-57n88v6t	81	8	R	r	NN
cord-034687-57n88v6t	81	9	widely	widely	RB
cord-034687-57n88v6t	81	10	distributed	distribute	VBD
cord-034687-57n88v6t	81	11	thorough	thorough	JJ
cord-034687-57n88v6t	81	12	the	the	DT
cord-034687-57n88v6t	81	13	brain	brain	NN
cord-034687-57n88v6t	81	14	have	have	VBP
cord-034687-57n88v6t	81	15	been	be	VBN
cord-034687-57n88v6t	81	16	described	describe	VBN
cord-034687-57n88v6t	81	17	:	:	:
cord-034687-57n88v6t	81	18	cortical	cortical	JJ
cord-034687-57n88v6t	81	19	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	81	20	and	and	CC
cord-034687-57n88v6t	81	21	GABAergic	gabaergic	NN
cord-034687-57n88v6t	81	22	forebrain	forebrain	NN
cord-034687-57n88v6t	81	23	neurons	neuron	NNS
cord-034687-57n88v6t	81	24	.	.	.
cord-034687-57n88v6t	82	1	The	the	DT
cord-034687-57n88v6t	82	2	equilibrium	equilibrium	NN
cord-034687-57n88v6t	82	3	between	between	IN
cord-034687-57n88v6t	82	4	GABAergic	gabaergic	NN
cord-034687-57n88v6t	82	5	and	and	CC
cord-034687-57n88v6t	82	6	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	82	7	transmission	transmission	NN
cord-034687-57n88v6t	82	8	provides	provide	VBZ
cord-034687-57n88v6t	82	9	an	an	DT
cord-034687-57n88v6t	82	10	appropriate	appropriate	JJ
cord-034687-57n88v6t	82	11	emotional	emotional	JJ
cord-034687-57n88v6t	82	12	reactivity	reactivity	NN
cord-034687-57n88v6t	82	13	in	in	IN
cord-034687-57n88v6t	82	14	physiological	physiological	JJ
cord-034687-57n88v6t	82	15	conditions	condition	NNS
cord-034687-57n88v6t	82	16	(	(	-LRB-
cord-034687-57n88v6t	82	17	Figure	figure	NN
cord-034687-57n88v6t	82	18	 	 	_SP
cord-034687-57n88v6t	82	19	2	2	CD
cord-034687-57n88v6t	82	20	)	)	-RRB-
cord-034687-57n88v6t	82	21	.	.	.
cord-034687-57n88v6t	83	1	Under	under	IN
cord-034687-57n88v6t	83	2	stressful	stressful	JJ
cord-034687-57n88v6t	83	3	circumstances	circumstance	NNS
cord-034687-57n88v6t	83	4	,	,	,
cord-034687-57n88v6t	83	5	the	the	DT
cord-034687-57n88v6t	83	6	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	83	7	tone	tone	NN
cord-034687-57n88v6t	83	8	increases	increase	NNS
cord-034687-57n88v6t	83	9	,	,	,
cord-034687-57n88v6t	83	10	producing	produce	VBG
cord-034687-57n88v6t	83	11	an	an	DT
cord-034687-57n88v6t	83	12	imbalance	imbalance	NN
cord-034687-57n88v6t	83	13	between	between	IN
cord-034687-57n88v6t	83	14	excitatory	excitatory	JJ
cord-034687-57n88v6t	83	15	and	and	CC
cord-034687-57n88v6t	83	16	inhibitory	inhibitory	JJ
cord-034687-57n88v6t	83	17	transmission	transmission	NN
cord-034687-57n88v6t	83	18	.	.	.
cord-034687-57n88v6t	84	1	To	to	TO
cord-034687-57n88v6t	84	2	compensate	compensate	VB
cord-034687-57n88v6t	84	3	for	for	IN
cord-034687-57n88v6t	84	4	this	this	DT
cord-034687-57n88v6t	84	5	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	84	6	overexcitation	overexcitation	NN
cord-034687-57n88v6t	84	7	,	,	,
cord-034687-57n88v6t	84	8	an	an	DT
cord-034687-57n88v6t	84	9	adaptive	adaptive	JJ
cord-034687-57n88v6t	84	10	compensatory	compensatory	JJ
cord-034687-57n88v6t	84	11	mechanism	mechanism	NN
cord-034687-57n88v6t	84	12	is	be	VBZ
cord-034687-57n88v6t	84	13	activated	activate	VBN
cord-034687-57n88v6t	84	14	by	by	IN
cord-034687-57n88v6t	84	15	CB	CB	NNP
cord-034687-57n88v6t	84	16	1	1	CD
cord-034687-57n88v6t	84	17	R	r	NN
cord-034687-57n88v6t	84	18	downregulation	downregulation	NN
cord-034687-57n88v6t	84	19	in	in	IN
cord-034687-57n88v6t	84	20	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	84	21	terminals	terminal	NNS
cord-034687-57n88v6t	84	22	.	.	.
cord-034687-57n88v6t	85	1	This	this	DT
cord-034687-57n88v6t	85	2	downregulation	downregulation	NN
cord-034687-57n88v6t	85	3	promotes	promote	VBZ
cord-034687-57n88v6t	85	4	increased	increase	VBN
cord-034687-57n88v6t	85	5	GABAergic	gabaergic	JJ
cord-034687-57n88v6t	85	6	inhibition	inhibition	NN
cord-034687-57n88v6t	85	7	of	of	IN
cord-034687-57n88v6t	85	8	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	85	9	transmission	transmission	NN
cord-034687-57n88v6t	85	10	that	that	WDT
cord-034687-57n88v6t	85	11	reestablishes	reestablish	VBZ
cord-034687-57n88v6t	85	12	the	the	DT
cord-034687-57n88v6t	85	13	equilibrium	equilibrium	NN
cord-034687-57n88v6t	85	14	between	between	IN
cord-034687-57n88v6t	85	15	excitation	excitation	NN
cord-034687-57n88v6t	85	16	and	and	CC
cord-034687-57n88v6t	85	17	inhibition	inhibition	NN
cord-034687-57n88v6t	85	18	.	.	.
cord-034687-57n88v6t	86	1	8	8	CD
cord-034687-57n88v6t	87	1	The	the	DT
cord-034687-57n88v6t	87	2	behavior	behavior	NN
cord-034687-57n88v6t	87	3	of	of	IN
cord-034687-57n88v6t	87	4	mutant	mutant	JJ
cord-034687-57n88v6t	87	5	mice	mouse	NNS
cord-034687-57n88v6t	87	6	lacking	lack	VBG
cord-034687-57n88v6t	87	7	CB	CB	NNP
cord-034687-57n88v6t	87	8	1	1	CD
cord-034687-57n88v6t	87	9	R	r	NN
cord-034687-57n88v6t	87	10	in	in	IN
cord-034687-57n88v6t	87	11	cortical	cortical	JJ
cord-034687-57n88v6t	87	12	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	87	13	neurons	neuron	NNS
cord-034687-57n88v6t	87	14	indicates	indicate	VBZ
cord-034687-57n88v6t	87	15	that	that	IN
cord-034687-57n88v6t	87	16	the	the	DT
cord-034687-57n88v6t	87	17	modulatory	modulatory	JJ
cord-034687-57n88v6t	87	18	effect	effect	NN
cord-034687-57n88v6t	87	19	of	of	IN
cord-034687-57n88v6t	87	20	CB	CB	NNP
cord-034687-57n88v6t	87	21	1	1	CD
cord-034687-57n88v6t	87	22	R	r	NN
cord-034687-57n88v6t	87	23	in	in	IN
cord-034687-57n88v6t	87	24	these	these	DT
cord-034687-57n88v6t	87	25	excitatory	excitatory	JJ
cord-034687-57n88v6t	87	26	neurons	neuron	NNS
cord-034687-57n88v6t	87	27	plays	play	VBZ
cord-034687-57n88v6t	87	28	a	a	DT
cord-034687-57n88v6t	87	29	complementary	complementary	JJ
cord-034687-57n88v6t	87	30	role	role	NN
cord-034687-57n88v6t	87	31	in	in	IN
cord-034687-57n88v6t	87	32	fear	fear	NN
cord-034687-57n88v6t	87	33	extinction	extinction	NN
cord-034687-57n88v6t	87	34	.	.	.
cord-034687-57n88v6t	88	1	10	10	CD
cord-034687-57n88v6t	89	1	Therefore	therefore	RB
cord-034687-57n88v6t	89	2	,	,	,
cord-034687-57n88v6t	89	3	the	the	DT
cord-034687-57n88v6t	89	4	role	role	NN
cord-034687-57n88v6t	89	5	of	of	IN
cord-034687-57n88v6t	89	6	CB	CB	NNP
cord-034687-57n88v6t	89	7	1	1	CD
cord-034687-57n88v6t	89	8	R	r	NN
cord-034687-57n88v6t	89	9	depends	depend	VBZ
cord-034687-57n88v6t	89	10	on	on	IN
cord-034687-57n88v6t	89	11	the	the	DT
cord-034687-57n88v6t	89	12	specific	specific	JJ
cord-034687-57n88v6t	89	13	cell	cell	NN
cord-034687-57n88v6t	89	14	type	type	NN
cord-034687-57n88v6t	89	15	and	and	CC
cord-034687-57n88v6t	89	16	brain	brain	NN
cord-034687-57n88v6t	89	17	region	region	NN
cord-034687-57n88v6t	89	18	where	where	WRB
cord-034687-57n88v6t	89	19	they	-PRON-	PRP
cord-034687-57n88v6t	89	20	are	be	VBP
cord-034687-57n88v6t	89	21	expressed	express	VBN
cord-034687-57n88v6t	89	22	.	.	.
cord-034687-57n88v6t	90	1	Importantly	importantly	RB
cord-034687-57n88v6t	90	2	,	,	,
cord-034687-57n88v6t	90	3	the	the	DT
cord-034687-57n88v6t	90	4	deletion	deletion	NN
cord-034687-57n88v6t	90	5	of	of	IN
cord-034687-57n88v6t	90	6	CB	CB	NNP
cord-034687-57n88v6t	90	7	1	1	CD
cord-034687-57n88v6t	90	8	R	r	NN
cord-034687-57n88v6t	90	9	in	in	IN
cord-034687-57n88v6t	90	10	forebrain	forebrain	JJ
cord-034687-57n88v6t	90	11	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	90	12	neurons	neuron	NNS
cord-034687-57n88v6t	90	13	of	of	IN
cord-034687-57n88v6t	90	14	GABA	GABA	NNP
cord-034687-57n88v6t	90	15	-	-	HYPH
cord-034687-57n88v6t	90	16	CB	CB	NNP
cord-034687-57n88v6t	90	17	1	1	CD
cord-034687-57n88v6t	90	18	R	r	NN
cord-034687-57n88v6t	90	19	knockouts	knockout	NNS
cord-034687-57n88v6t	90	20	leads	lead	VBZ
cord-034687-57n88v6t	90	21	to	to	IN
cord-034687-57n88v6t	90	22	an	an	DT
cord-034687-57n88v6t	90	23	augmentation	augmentation	NN
cord-034687-57n88v6t	90	24	of	of	IN
cord-034687-57n88v6t	90	25	active	active	JJ
cord-034687-57n88v6t	90	26	coping	cope	VBG
cord-034687-57n88v6t	90	27	strategies	strategy	NNS
cord-034687-57n88v6t	90	28	in	in	IN
cord-034687-57n88v6t	90	29	the	the	DT
cord-034687-57n88v6t	90	30	fear	fear	NN
cord-034687-57n88v6t	90	31	conditioning	conditioning	NN
cord-034687-57n88v6t	90	32	paradigm	paradigm	NN
cord-034687-57n88v6t	90	33	,	,	,
cord-034687-57n88v6t	90	34	possibly	possibly	RB
cord-034687-57n88v6t	90	35	due	due	IN
cord-034687-57n88v6t	90	36	to	to	IN
cord-034687-57n88v6t	90	37	an	an	DT
cord-034687-57n88v6t	90	38	increased	increase	VBN
cord-034687-57n88v6t	90	39	inhibition	inhibition	NN
cord-034687-57n88v6t	90	40	of	of	IN
cord-034687-57n88v6t	90	41	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	90	42	cells	cell	NNS
cord-034687-57n88v6t	90	43	in	in	IN
cord-034687-57n88v6t	90	44	the	the	DT
cord-034687-57n88v6t	90	45	basolateral	basolateral	JJ
cord-034687-57n88v6t	90	46	amygdala	amygdala	NN
cord-034687-57n88v6t	90	47	(	(	-LRB-
cord-034687-57n88v6t	90	48	BLA	BLA	NNP
cord-034687-57n88v6t	90	49	)	)	-RRB-
cord-034687-57n88v6t	90	50	,	,	,
cord-034687-57n88v6t	90	51	which	which	WDT
cord-034687-57n88v6t	90	52	reduces	reduce	VBZ
cord-034687-57n88v6t	90	53	central	central	JJ
cord-034687-57n88v6t	90	54	amygdala	amygdala	NNP
cord-034687-57n88v6t	90	55	(	(	-LRB-
cord-034687-57n88v6t	90	56	CeA	CeA	NNP
cord-034687-57n88v6t	90	57	)	)	-RRB-
cord-034687-57n88v6t	90	58	excitation	excitation	NN
cord-034687-57n88v6t	90	59	.	.	.
cord-034687-57n88v6t	91	1	11	11	CD
cord-034687-57n88v6t	92	1	Conversely	conversely	RB
cord-034687-57n88v6t	92	2	,	,	,
cord-034687-57n88v6t	92	3	the	the	DT
cord-034687-57n88v6t	92	4	deletion	deletion	NN
cord-034687-57n88v6t	92	5	of	of	IN
cord-034687-57n88v6t	92	6	CB	CB	NNP
cord-034687-57n88v6t	92	7	1	1	CD
cord-034687-57n88v6t	92	8	R	r	NN
cord-034687-57n88v6t	92	9	in	in	IN
cord-034687-57n88v6t	92	10	cortical	cortical	JJ
cord-034687-57n88v6t	92	11	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	92	12	neurons	neuron	NNS
cord-034687-57n88v6t	92	13	of	of	IN
cord-034687-57n88v6t	92	14	Glu	Glu	NNP
cord-034687-57n88v6t	92	15	-	-	HYPH
cord-034687-57n88v6t	92	16	CB	CB	NNP
cord-034687-57n88v6t	92	17	1	1	CD
cord-034687-57n88v6t	92	18	R	r	NN
cord-034687-57n88v6t	92	19	knockouts	knockout	NNS
cord-034687-57n88v6t	92	20	induces	induce	VBZ
cord-034687-57n88v6t	92	21	augmentation	augmentation	NN
cord-034687-57n88v6t	92	22	of	of	IN
cord-034687-57n88v6t	92	23	passive	passive	JJ
cord-034687-57n88v6t	92	24	coping	cope	VBG
cord-034687-57n88v6t	92	25	strategies	strategy	NNS
cord-034687-57n88v6t	92	26	in	in	IN
cord-034687-57n88v6t	92	27	the	the	DT
cord-034687-57n88v6t	92	28	fear	fear	NN
cord-034687-57n88v6t	92	29	conditioning	conditioning	NN
cord-034687-57n88v6t	92	30	paradigm	paradigm	NN
cord-034687-57n88v6t	92	31	,	,	,
cord-034687-57n88v6t	92	32	possibly	possibly	RB
cord-034687-57n88v6t	92	33	due	due	JJ
cord-034687-57n88v6t	92	34	to	to	IN
cord-034687-57n88v6t	92	35	increased	increase	VBN
cord-034687-57n88v6t	92	36	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	92	37	excitation	excitation	NN
cord-034687-57n88v6t	92	38	in	in	IN
cord-034687-57n88v6t	92	39	the	the	DT
cord-034687-57n88v6t	92	40	BLA	BLA	NNP
cord-034687-57n88v6t	92	41	,	,	,
cord-034687-57n88v6t	92	42	which	which	WDT
cord-034687-57n88v6t	92	43	results	result	VBZ
cord-034687-57n88v6t	92	44	in	in	IN
cord-034687-57n88v6t	92	45	CeA	CeA	NNP
cord-034687-57n88v6t	92	46	hyperactivation	hyperactivation	NNP
cord-034687-57n88v6t	92	47	.	.	.
cord-034687-57n88v6t	93	1	11	11	CD
cord-034687-57n88v6t	94	1	These	these	DT
cord-034687-57n88v6t	94	2	results	result	NNS
cord-034687-57n88v6t	94	3	point	point	VBP
cord-034687-57n88v6t	94	4	to	to	IN
cord-034687-57n88v6t	94	5	a	a	DT
cord-034687-57n88v6t	94	6	bimodal	bimodal	JJ
cord-034687-57n88v6t	94	7	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	94	8	control	control	NN
cord-034687-57n88v6t	94	9	of	of	IN
cord-034687-57n88v6t	94	10	fear	fear	NN
cord-034687-57n88v6t	94	11	in	in	IN
cord-034687-57n88v6t	94	12	amygdala	amygdala	NN
cord-034687-57n88v6t	94	13	-	-	HYPH
cord-034687-57n88v6t	94	14	dependent	dependent	JJ
cord-034687-57n88v6t	94	15	circuits	circuit	NNS
cord-034687-57n88v6t	94	16	12	12	CD
cord-034687-57n88v6t	95	1	(	(	-LRB-
cord-034687-57n88v6t	95	2	Figure	figure	NN
cord-034687-57n88v6t	95	3	2	2	CD
cord-034687-57n88v6t	95	4	)	)	-RRB-
cord-034687-57n88v6t	95	5	.	.	.
cord-034687-57n88v6t	96	1	In	in	IN
cord-034687-57n88v6t	96	2	agreement	agreement	NN
cord-034687-57n88v6t	96	3	,	,	,
cord-034687-57n88v6t	96	4	low	low	JJ
cord-034687-57n88v6t	96	5	tetrahydrocannabinol	tetrahydrocannabinol	NN
cord-034687-57n88v6t	96	6	(	(	-LRB-
cord-034687-57n88v6t	96	7	THC	thc	NN
cord-034687-57n88v6t	96	8	)	)	-RRB-
cord-034687-57n88v6t	96	9	doses	dose	NNS
cord-034687-57n88v6t	96	10	have	have	VBP
cord-034687-57n88v6t	96	11	been	be	VBN
cord-034687-57n88v6t	96	12	proposed	propose	VBN
cord-034687-57n88v6t	96	13	to	to	TO
cord-034687-57n88v6t	96	14	act	act	VB
cord-034687-57n88v6t	96	15	preferentially	preferentially	RB
cord-034687-57n88v6t	96	16	at	at	IN
cord-034687-57n88v6t	96	17	CB	CB	NNP
cord-034687-57n88v6t	96	18	1	1	CD
cord-034687-57n88v6t	96	19	R	r	NN
cord-034687-57n88v6t	96	20	on	on	IN
cord-034687-57n88v6t	96	21	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	96	22	neurons	neuron	NNS
cord-034687-57n88v6t	96	23	,	,	,
cord-034687-57n88v6t	96	24	whereas	whereas	IN
cord-034687-57n88v6t	96	25	high	high	JJ
cord-034687-57n88v6t	96	26	THC	thc	NN
cord-034687-57n88v6t	96	27	doses	dose	NNS
cord-034687-57n88v6t	96	28	have	have	VBP
cord-034687-57n88v6t	96	29	been	be	VBN
cord-034687-57n88v6t	96	30	proposed	propose	VBN
cord-034687-57n88v6t	96	31	to	to	TO
cord-034687-57n88v6t	96	32	act	act	VB
cord-034687-57n88v6t	96	33	also	also	RB
cord-034687-57n88v6t	96	34	at	at	IN
cord-034687-57n88v6t	96	35	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	96	36	neurons	neuron	NNS
cord-034687-57n88v6t	96	37	.	.	.
cord-034687-57n88v6t	97	1	13	13	CD
cord-034687-57n88v6t	97	2	CB	CB	NNP
cord-034687-57n88v6t	97	3	1	1	CD
cord-034687-57n88v6t	97	4	R	r	NN
cord-034687-57n88v6t	97	5	is	be	VBZ
cord-034687-57n88v6t	97	6	less	less	RBR
cord-034687-57n88v6t	97	7	abundant	abundant	JJ
cord-034687-57n88v6t	97	8	on	on	IN
cord-034687-57n88v6t	97	9	cortical	cortical	JJ
cord-034687-57n88v6t	97	10	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	97	11	neurons	neuron	NNS
cord-034687-57n88v6t	97	12	,	,	,
cord-034687-57n88v6t	97	13	but	but	CC
cord-034687-57n88v6t	97	14	its	-PRON-	PRP$
cord-034687-57n88v6t	97	15	activation	activation	NN
cord-034687-57n88v6t	97	16	produces	produce	VBZ
cord-034687-57n88v6t	97	17	more	more	RBR
cord-034687-57n88v6t	97	18	pronounced	pronounce	VBN
cord-034687-57n88v6t	97	19	effects	effect	NNS
cord-034687-57n88v6t	97	20	than	than	IN
cord-034687-57n88v6t	97	21	on	on	IN
cord-034687-57n88v6t	97	22	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	97	23	neurons	neuron	NNS
cord-034687-57n88v6t	97	24	.	.	.
cord-034687-57n88v6t	98	1	14	14	CD
cord-034687-57n88v6t	99	1	Furthermore	furthermore	RB
cord-034687-57n88v6t	99	2	,	,	,
cord-034687-57n88v6t	99	3	CB	CB	NNP
cord-034687-57n88v6t	99	4	1	1	CD
cord-034687-57n88v6t	99	5	R	R	NNP
cord-034687-57n88v6t	99	6	antagonists	antagonist	NNS
cord-034687-57n88v6t	99	7	microinjected	microinjecte	VBN
cord-034687-57n88v6t	99	8	in	in	IN
cord-034687-57n88v6t	99	9	the	the	DT
cord-034687-57n88v6t	99	10	BLA	BLA	NNP
cord-034687-57n88v6t	99	11	impair	impair	VB
cord-034687-57n88v6t	99	12	long	long	JJ
cord-034687-57n88v6t	99	13	-	-	HYPH
cord-034687-57n88v6t	99	14	term	term	NN
cord-034687-57n88v6t	99	15	extinction	extinction	NN
cord-034687-57n88v6t	99	16	,	,	,
cord-034687-57n88v6t	99	17	and	and	CC
cord-034687-57n88v6t	99	18	CB	CB	NNP
cord-034687-57n88v6t	99	19	1	1	CD
cord-034687-57n88v6t	99	20	R	r	NN
cord-034687-57n88v6t	99	21	antagonism	antagonism	NN
cord-034687-57n88v6t	99	22	into	into	IN
cord-034687-57n88v6t	99	23	the	the	DT
cord-034687-57n88v6t	99	24	CeA	CeA	NNP
cord-034687-57n88v6t	99	25	reduces	reduce	VBZ
cord-034687-57n88v6t	99	26	within	within	IN
cord-034687-57n88v6t	99	27	-	-	HYPH
cord-034687-57n88v6t	99	28	session	session	NN
cord-034687-57n88v6t	99	29	extinction	extinction	NN
cord-034687-57n88v6t	99	30	.	.	.
cord-034687-57n88v6t	100	1	15	15	CD
cord-034687-57n88v6t	101	1	The	the	DT
cord-034687-57n88v6t	101	2	infralimbic	infralimbic	NNP
cord-034687-57n88v6t	101	3	PFC	PFC	NNP
cord-034687-57n88v6t	101	4	also	also	RB
cord-034687-57n88v6t	101	5	has	have	VBZ
cord-034687-57n88v6t	101	6	an	an	DT
cord-034687-57n88v6t	101	7	important	important	JJ
cord-034687-57n88v6t	101	8	role	role	NN
cord-034687-57n88v6t	101	9	in	in	IN
cord-034687-57n88v6t	101	10	fear	fear	NN
cord-034687-57n88v6t	101	11	extinction	extinction	NN
cord-034687-57n88v6t	101	12	,	,	,
cord-034687-57n88v6t	101	13	as	as	IN
cord-034687-57n88v6t	101	14	shown	show	VBN
cord-034687-57n88v6t	101	15	by	by	IN
cord-034687-57n88v6t	101	16	the	the	DT
cord-034687-57n88v6t	101	17	impaired	impair	VBN
cord-034687-57n88v6t	101	18	fear	fear	NN
cord-034687-57n88v6t	101	19	extinction	extinction	NN
cord-034687-57n88v6t	101	20	after	after	IN
cord-034687-57n88v6t	101	21	CB	CB	NNP
cord-034687-57n88v6t	101	22	1	1	CD
cord-034687-57n88v6t	101	23	R	r	NN
cord-034687-57n88v6t	101	24	blockade	blockade	NN
cord-034687-57n88v6t	101	25	in	in	IN
cord-034687-57n88v6t	101	26	this	this	DT
cord-034687-57n88v6t	101	27	subregion	subregion	NN
cord-034687-57n88v6t	101	28	.	.	.
cord-034687-57n88v6t	102	1	16	16	CD
cord-034687-57n88v6t	103	1	In	in	IN
cord-034687-57n88v6t	103	2	agreement	agreement	NN
cord-034687-57n88v6t	103	3	with	with	IN
cord-034687-57n88v6t	103	4	these	these	DT
cord-034687-57n88v6t	103	5	data	datum	NNS
cord-034687-57n88v6t	103	6	,	,	,
cord-034687-57n88v6t	103	7	mice	mouse	NNS
cord-034687-57n88v6t	103	8	deficient	deficient	JJ
cord-034687-57n88v6t	103	9	in	in	IN
cord-034687-57n88v6t	103	10	diacylglycerol	diacylglycerol	NN
cord-034687-57n88v6t	103	11	lipase	lipase	NN
cord-034687-57n88v6t	103	12	-	-	HYPH
cord-034687-57n88v6t	103	13	α	α	NN
cord-034687-57n88v6t	103	14	(	(	-LRB-
cord-034687-57n88v6t	103	15	DAGLα	DAGLα	NNS
cord-034687-57n88v6t	103	16	)	)	-RRB-
cord-034687-57n88v6t	103	17	,	,	,
cord-034687-57n88v6t	103	18	the	the	DT
cord-034687-57n88v6t	103	19	enzyme	enzyme	NN
cord-034687-57n88v6t	103	20	involved	involve	VBN
cord-034687-57n88v6t	103	21	in	in	IN
cord-034687-57n88v6t	103	22	2-AG	2-ag	CD
cord-034687-57n88v6t	103	23	synthesis	synthesis	NN
cord-034687-57n88v6t	103	24	,	,	,
cord-034687-57n88v6t	103	25	have	have	VBP
cord-034687-57n88v6t	103	26	reduced	reduce	VBN
cord-034687-57n88v6t	103	27	2-AG	2-ag	CD
cord-034687-57n88v6t	103	28	brain	brain	NN
cord-034687-57n88v6t	103	29	levels	level	NNS
cord-034687-57n88v6t	103	30	and	and	CC
cord-034687-57n88v6t	103	31	display	display	VB
cord-034687-57n88v6t	103	32	a	a	DT
cord-034687-57n88v6t	103	33	phenotype	phenotype	NN
cord-034687-57n88v6t	103	34	related	relate	VBN
cord-034687-57n88v6t	103	35	to	to	IN
cord-034687-57n88v6t	103	36	impaired	impaired	JJ
cord-034687-57n88v6t	103	37	fear	fear	NN
cord-034687-57n88v6t	103	38	extinction	extinction	NN
cord-034687-57n88v6t	103	39	.	.	.
cord-034687-57n88v6t	104	1	17	17	CD
cord-034687-57n88v6t	105	1	In	in	IN
cord-034687-57n88v6t	105	2	contrast	contrast	NN
cord-034687-57n88v6t	105	3	,	,	,
cord-034687-57n88v6t	105	4	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	105	5	inhibition	inhibition	NN
cord-034687-57n88v6t	105	6	of	of	IN
cord-034687-57n88v6t	105	7	monoacylglycerol	monoacylglycerol	NNP
cord-034687-57n88v6t	105	8	lipase	lipase	NNP
cord-034687-57n88v6t	105	9	(	(	-LRB-
cord-034687-57n88v6t	105	10	MAGL	MAGL	NNP
cord-034687-57n88v6t	105	11	)	)	-RRB-
cord-034687-57n88v6t	105	12	,	,	,
cord-034687-57n88v6t	105	13	the	the	DT
cord-034687-57n88v6t	105	14	enzyme	enzyme	NN
cord-034687-57n88v6t	105	15	involved	involve	VBN
cord-034687-57n88v6t	105	16	in	in	IN
cord-034687-57n88v6t	105	17	2-AG	2-ag	CD
cord-034687-57n88v6t	105	18	degradation	degradation	NN
cord-034687-57n88v6t	105	19	,	,	,
cord-034687-57n88v6t	105	20	enhances	enhance	VBZ
cord-034687-57n88v6t	105	21	2-AG	2-ag	CD
cord-034687-57n88v6t	105	22	levels	level	NNS
cord-034687-57n88v6t	105	23	and	and	CC
cord-034687-57n88v6t	105	24	impairs	impair	VBZ
cord-034687-57n88v6t	105	25	fear	fear	VBP
cord-034687-57n88v6t	105	26	extinction	extinction	NN
cord-034687-57n88v6t	105	27	via	via	IN
cord-034687-57n88v6t	105	28	CB	CB	NNP
cord-034687-57n88v6t	105	29	1	1	CD
cord-034687-57n88v6t	105	30	R	r	NN
cord-034687-57n88v6t	105	31	of	of	IN
cord-034687-57n88v6t	105	32	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	105	33	neurons	neuron	NNS
cord-034687-57n88v6t	105	34	.	.	.
cord-034687-57n88v6t	106	1	17	17	CD
cord-034687-57n88v6t	107	1	These	these	DT
cord-034687-57n88v6t	107	2	results	result	NNS
cord-034687-57n88v6t	107	3	suggest	suggest	VBP
cord-034687-57n88v6t	107	4	that	that	IN
cord-034687-57n88v6t	107	5	an	an	DT
cord-034687-57n88v6t	107	6	optimal	optimal	JJ
cord-034687-57n88v6t	107	7	level	level	NN
cord-034687-57n88v6t	107	8	of	of	IN
cord-034687-57n88v6t	107	9	2-AG	2-ag	CD
cord-034687-57n88v6t	107	10	is	be	VBZ
cord-034687-57n88v6t	107	11	needed	need	VBN
cord-034687-57n88v6t	107	12	for	for	IN
cord-034687-57n88v6t	107	13	appropriate	appropriate	JJ
cord-034687-57n88v6t	107	14	processing	processing	NN
cord-034687-57n88v6t	107	15	of	of	IN
cord-034687-57n88v6t	107	16	fear	fear	NN
cord-034687-57n88v6t	107	17	responses	response	NNS
cord-034687-57n88v6t	107	18	and	and	CC
cord-034687-57n88v6t	107	19	that	that	IN
cord-034687-57n88v6t	107	20	altered	alter	VBD
cord-034687-57n88v6t	107	21	2-AG	2-ag	CD
cord-034687-57n88v6t	107	22	levels	level	NNS
cord-034687-57n88v6t	107	23	impair	impair	VBP
cord-034687-57n88v6t	107	24	the	the	DT
cord-034687-57n88v6t	107	25	extinction	extinction	NN
cord-034687-57n88v6t	107	26	process	process	NN
cord-034687-57n88v6t	107	27	.	.	.
cord-034687-57n88v6t	108	1	5	5	LS
cord-034687-57n88v6t	109	1	With	with	IN
cord-034687-57n88v6t	109	2	respect	respect	NN
cord-034687-57n88v6t	109	3	to	to	IN
cord-034687-57n88v6t	109	4	anandamide	anandamide	NN
cord-034687-57n88v6t	109	5	,	,	,
cord-034687-57n88v6t	109	6	inhibition	inhibition	NN
cord-034687-57n88v6t	109	7	of	of	IN
cord-034687-57n88v6t	109	8	the	the	DT
cord-034687-57n88v6t	109	9	enzyme	enzyme	NN
cord-034687-57n88v6t	109	10	involved	involve	VBN
cord-034687-57n88v6t	109	11	in	in	IN
cord-034687-57n88v6t	109	12	its	-PRON-	PRP$
cord-034687-57n88v6t	109	13	degradation	degradation	NN
cord-034687-57n88v6t	109	14	,	,	,
cord-034687-57n88v6t	109	15	fatty	fatty	JJ
cord-034687-57n88v6t	109	16	acid	acid	NN
cord-034687-57n88v6t	109	17	amide	amide	NN
cord-034687-57n88v6t	109	18	hydrolase	hydrolase	NN
cord-034687-57n88v6t	109	19	(	(	-LRB-
cord-034687-57n88v6t	109	20	FAAH	FAAH	NNP
cord-034687-57n88v6t	109	21	)	)	-RRB-
cord-034687-57n88v6t	109	22	in	in	IN
cord-034687-57n88v6t	109	23	the	the	DT
cord-034687-57n88v6t	109	24	BLA	BLA	NNP
cord-034687-57n88v6t	109	25	,	,	,
cord-034687-57n88v6t	109	26	facilitates	facilitate	VBZ
cord-034687-57n88v6t	109	27	fear	fear	NN
cord-034687-57n88v6t	109	28	extinction	extinction	NN
cord-034687-57n88v6t	109	29	by	by	IN
cord-034687-57n88v6t	109	30	CB	CB	NNP
cord-034687-57n88v6t	109	31	1	1	CD
cord-034687-57n88v6t	109	32	R	r	NN
cord-034687-57n88v6t	109	33	activation	activation	NN
cord-034687-57n88v6t	109	34	.	.	.
cord-034687-57n88v6t	110	1	18	18	CD
cord-034687-57n88v6t	111	1	Re	re	NN
cord-034687-57n88v6t	111	2	-	-	NN
cord-034687-57n88v6t	111	3	exposure	exposure	NN
cord-034687-57n88v6t	111	4	to	to	IN
cord-034687-57n88v6t	111	5	the	the	DT
cord-034687-57n88v6t	111	6	CS	CS	NNP
cord-034687-57n88v6t	111	7	alone	alone	RB
cord-034687-57n88v6t	111	8	increases	increase	VBZ
cord-034687-57n88v6t	111	9	the	the	DT
cord-034687-57n88v6t	111	10	activity	activity	NN
cord-034687-57n88v6t	111	11	of	of	IN
cord-034687-57n88v6t	111	12	the	the	DT
cord-034687-57n88v6t	111	13	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	111	14	system	system	NN
cord-034687-57n88v6t	111	15	to	to	TO
cord-034687-57n88v6t	111	16	promote	promote	VB
cord-034687-57n88v6t	111	17	extinction	extinction	NN
cord-034687-57n88v6t	111	18	,	,	,
cord-034687-57n88v6t	111	19	and	and	CC
cord-034687-57n88v6t	111	20	the	the	DT
cord-034687-57n88v6t	111	21	fear	fear	NN
cord-034687-57n88v6t	111	22	response	response	NN
cord-034687-57n88v6t	111	23	is	be	VBZ
cord-034687-57n88v6t	111	24	reduced	reduce	VBN
cord-034687-57n88v6t	111	25	after	after	IN
cord-034687-57n88v6t	111	26	CB	CB	NNP
cord-034687-57n88v6t	111	27	1	1	CD
cord-034687-57n88v6t	111	28	R	r	NN
cord-034687-57n88v6t	111	29	activation	activation	NN
cord-034687-57n88v6t	111	30	.	.	.
cord-034687-57n88v6t	112	1	5	5	LS
cord-034687-57n88v6t	113	1	Therefore	therefore	RB
cord-034687-57n88v6t	113	2	,	,	,
cord-034687-57n88v6t	113	3	the	the	DT
cord-034687-57n88v6t	113	4	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	113	5	system	system	NN
cord-034687-57n88v6t	113	6	is	be	VBZ
cord-034687-57n88v6t	113	7	crucial	crucial	JJ
cord-034687-57n88v6t	113	8	for	for	IN
cord-034687-57n88v6t	113	9	appropriate	appropriate	JJ
cord-034687-57n88v6t	113	10	fear	fear	NN
cord-034687-57n88v6t	113	11	extinction	extinction	NN
cord-034687-57n88v6t	113	12	.	.	.
cord-034687-57n88v6t	114	1	On	on	IN
cord-034687-57n88v6t	114	2	the	the	DT
cord-034687-57n88v6t	114	3	other	other	JJ
cord-034687-57n88v6t	114	4	hand	hand	NN
cord-034687-57n88v6t	114	5	,	,	,
cord-034687-57n88v6t	114	6	chronic	chronic	JJ
cord-034687-57n88v6t	114	7	stress	stress	NN
cord-034687-57n88v6t	114	8	can	can	MD
cord-034687-57n88v6t	114	9	have	have	VB
cord-034687-57n88v6t	114	10	deleterious	deleterious	JJ
cord-034687-57n88v6t	114	11	effects	effect	NNS
cord-034687-57n88v6t	114	12	regarding	regard	VBG
cord-034687-57n88v6t	114	13	the	the	DT
cord-034687-57n88v6t	114	14	extinction	extinction	NN
cord-034687-57n88v6t	114	15	of	of	IN
cord-034687-57n88v6t	114	16	conditioned	condition	VBN
cord-034687-57n88v6t	114	17	fear	fear	NN
cord-034687-57n88v6t	114	18	,	,	,
cord-034687-57n88v6t	114	19	which	which	WDT
cord-034687-57n88v6t	114	20	may	may	MD
cord-034687-57n88v6t	114	21	interfere	interfere	VB
cord-034687-57n88v6t	114	22	in	in	IN
cord-034687-57n88v6t	114	23	the	the	DT
cord-034687-57n88v6t	114	24	treatment	treatment	NN
cord-034687-57n88v6t	114	25	of	of	IN
cord-034687-57n88v6t	114	26	PTSD	PTSD	NNP
cord-034687-57n88v6t	114	27	patients	patient	NNS
cord-034687-57n88v6t	114	28	.	.	.
cord-034687-57n88v6t	115	1	It	-PRON-	PRP
cord-034687-57n88v6t	115	2	is	be	VBZ
cord-034687-57n88v6t	115	3	hypothesized	hypothesize	VBN
cord-034687-57n88v6t	115	4	that	that	IN
cord-034687-57n88v6t	115	5	chronic	chronic	JJ
cord-034687-57n88v6t	115	6	stress	stress	NN
cord-034687-57n88v6t	115	7	creates	create	VBZ
cord-034687-57n88v6t	115	8	a	a	DT
cord-034687-57n88v6t	115	9	hypocannabinergic	hypocannabinergic	NN
cord-034687-57n88v6t	115	10	state	state	NN
cord-034687-57n88v6t	115	11	resulting	result	VBG
cord-034687-57n88v6t	115	12	in	in	IN
cord-034687-57n88v6t	115	13	impaired	impaired	JJ
cord-034687-57n88v6t	115	14	fear	fear	NN
cord-034687-57n88v6t	115	15	extinction	extinction	NN
cord-034687-57n88v6t	115	16	that	that	WDT
cord-034687-57n88v6t	115	17	can	can	MD
cord-034687-57n88v6t	115	18	be	be	VB
cord-034687-57n88v6t	115	19	alleviated	alleviate	VBN
cord-034687-57n88v6t	115	20	by	by	IN
cord-034687-57n88v6t	115	21	CB	CB	NNP
cord-034687-57n88v6t	115	22	1	1	CD
cord-034687-57n88v6t	115	23	R	r	NN
cord-034687-57n88v6t	115	24	agonists	agonist	NNS
cord-034687-57n88v6t	115	25	.	.	.
cord-034687-57n88v6t	116	1	5	5	CD
cord-034687-57n88v6t	116	2	Chronic	chronic	JJ
cord-034687-57n88v6t	116	3	stress	stress	NN
cord-034687-57n88v6t	116	4	can	can	MD
cord-034687-57n88v6t	116	5	produce	produce	VB
cord-034687-57n88v6t	116	6	a	a	DT
cord-034687-57n88v6t	116	7	switch	switch	NN
cord-034687-57n88v6t	116	8	from	from	IN
cord-034687-57n88v6t	116	9	passive	passive	JJ
cord-034687-57n88v6t	116	10	to	to	IN
cord-034687-57n88v6t	116	11	active	active	JJ
cord-034687-57n88v6t	116	12	coping	coping	NN
cord-034687-57n88v6t	116	13	strategies	strategy	NNS
cord-034687-57n88v6t	116	14	,	,	,
cord-034687-57n88v6t	116	15	and	and	CC
cord-034687-57n88v6t	116	16	constitutive	constitutive	JJ
cord-034687-57n88v6t	116	17	CB	CB	NNP
cord-034687-57n88v6t	116	18	1	1	CD
cord-034687-57n88v6t	116	19	R	r	NN
cord-034687-57n88v6t	116	20	deletion	deletion	NN
cord-034687-57n88v6t	116	21	disrupts	disrupt	VBZ
cord-034687-57n88v6t	116	22	this	this	DT
cord-034687-57n88v6t	116	23	adaptation	adaptation	NN
cord-034687-57n88v6t	116	24	favoring	favor	VBG
cord-034687-57n88v6t	116	25	passive	passive	JJ
cord-034687-57n88v6t	116	26	responses	response	NNS
cord-034687-57n88v6t	116	27	that	that	WDT
cord-034687-57n88v6t	116	28	seem	seem	VBP
cord-034687-57n88v6t	116	29	to	to	TO
cord-034687-57n88v6t	116	30	depend	depend	VB
cord-034687-57n88v6t	116	31	on	on	IN
cord-034687-57n88v6t	116	32	CB	CB	NNP
cord-034687-57n88v6t	116	33	1	1	CD
cord-034687-57n88v6t	116	34	R	r	NN
cord-034687-57n88v6t	116	35	expressed	express	VBD
cord-034687-57n88v6t	116	36	on	on	IN
cord-034687-57n88v6t	116	37	cortical	cortical	JJ
cord-034687-57n88v6t	116	38	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	116	39	neurons	neuron	NNS
cord-034687-57n88v6t	116	40	.	.	.
cord-034687-57n88v6t	117	1	11	11	CD
cord-034687-57n88v6t	118	1	Conversely	conversely	RB
cord-034687-57n88v6t	118	2	,	,	,
cord-034687-57n88v6t	118	3	CB	CB	NNP
cord-034687-57n88v6t	118	4	1	1	CD
cord-034687-57n88v6t	118	5	R	r	NN
cord-034687-57n88v6t	118	6	expressed	express	VBD
cord-034687-57n88v6t	118	7	on	on	IN
cord-034687-57n88v6t	118	8	forebrain	forebrain	JJ
cord-034687-57n88v6t	118	9	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	118	10	neurons	neuron	NNS
cord-034687-57n88v6t	118	11	are	be	VBP
cord-034687-57n88v6t	118	12	related	relate	VBN
cord-034687-57n88v6t	118	13	to	to	IN
cord-034687-57n88v6t	118	14	coping	cope	VBG
cord-034687-57n88v6t	118	15	strategies	strategy	NNS
cord-034687-57n88v6t	118	16	because	because	IN
cord-034687-57n88v6t	118	17	mice	mouse	NNS
cord-034687-57n88v6t	118	18	lacking	lack	VBG
cord-034687-57n88v6t	118	19	CB	CB	NNP
cord-034687-57n88v6t	118	20	1	1	CD
cord-034687-57n88v6t	118	21	R	r	NN
cord-034687-57n88v6t	118	22	in	in	IN
cord-034687-57n88v6t	118	23	these	these	DT
cord-034687-57n88v6t	118	24	neurons	neuron	NNS
cord-034687-57n88v6t	118	25	display	display	VBP
cord-034687-57n88v6t	118	26	predominantly	predominantly	RB
cord-034687-57n88v6t	118	27	active	active	JJ
cord-034687-57n88v6t	118	28	behaviors	behavior	NNS
cord-034687-57n88v6t	118	29	.	.	.
cord-034687-57n88v6t	119	1	11	11	CD
cord-034687-57n88v6t	120	1	Importantly	importantly	RB
cord-034687-57n88v6t	120	2	,	,	,
cord-034687-57n88v6t	120	3	when	when	WRB
cord-034687-57n88v6t	120	4	the	the	DT
cord-034687-57n88v6t	120	5	responses	response	NNS
cord-034687-57n88v6t	120	6	to	to	IN
cord-034687-57n88v6t	120	7	CS	CS	NNP
cord-034687-57n88v6t	120	8	are	be	VBP
cord-034687-57n88v6t	120	9	measured	measure	VBN
cord-034687-57n88v6t	120	10	during	during	IN
cord-034687-57n88v6t	120	11	a	a	DT
cord-034687-57n88v6t	120	12	long	long	JJ
cord-034687-57n88v6t	120	13	-	-	HYPH
cord-034687-57n88v6t	120	14	term	term	NN
cord-034687-57n88v6t	120	15	period	period	NN
cord-034687-57n88v6t	120	16	of	of	IN
cord-034687-57n88v6t	120	17	CS	CS	NNP
cord-034687-57n88v6t	120	18	presentation	presentation	NN
cord-034687-57n88v6t	120	19	,	,	,
cord-034687-57n88v6t	120	20	no	no	DT
cord-034687-57n88v6t	120	21	differences	difference	NNS
cord-034687-57n88v6t	120	22	in	in	IN
cord-034687-57n88v6t	120	23	the	the	DT
cord-034687-57n88v6t	120	24	quantity	quantity	NN
cord-034687-57n88v6t	120	25	of	of	IN
cord-034687-57n88v6t	120	26	fear	fear	NN
cord-034687-57n88v6t	120	27	responses	response	NNS
cord-034687-57n88v6t	120	28	are	be	VBP
cord-034687-57n88v6t	120	29	observed	observe	VBN
cord-034687-57n88v6t	121	1	One	one	CD
cord-034687-57n88v6t	121	2	of	of	IN
cord-034687-57n88v6t	121	3	the	the	DT
cord-034687-57n88v6t	121	4	main	main	JJ
cord-034687-57n88v6t	121	5	medical	medical	JJ
cord-034687-57n88v6t	121	6	reasons	reason	NNS
cord-034687-57n88v6t	121	7	for	for	IN
cord-034687-57n88v6t	121	8	cannabis	cannabis	NN
cord-034687-57n88v6t	121	9	consumption	consumption	NN
cord-034687-57n88v6t	121	10	is	be	VBZ
cord-034687-57n88v6t	121	11	anxiety	anxiety	NN
cord-034687-57n88v6t	121	12	relief	relief	NN
cord-034687-57n88v6t	121	13	,	,	,
cord-034687-57n88v6t	121	14	although	although	IN
cord-034687-57n88v6t	121	15	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	121	16	responses	response	NNS
cord-034687-57n88v6t	121	17	are	be	VBP
cord-034687-57n88v6t	121	18	also	also	RB
cord-034687-57n88v6t	121	19	frequently	frequently	RB
cord-034687-57n88v6t	121	20	reported	report	VBN
cord-034687-57n88v6t	121	21	after	after	IN
cord-034687-57n88v6t	121	22	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	121	23	consumption	consumption	NN
cord-034687-57n88v6t	121	24	in	in	IN
cord-034687-57n88v6t	121	25	these	these	DT
cord-034687-57n88v6t	121	26	conditional	conditional	JJ
cord-034687-57n88v6t	121	27	mutant	mutant	JJ
cord-034687-57n88v6t	121	28	mice	mouse	NNS
cord-034687-57n88v6t	121	29	,	,	,
cord-034687-57n88v6t	121	30	suggesting	suggest	VBG
cord-034687-57n88v6t	121	31	that	that	IN
cord-034687-57n88v6t	121	32	CB	CB	NNP
cord-034687-57n88v6t	121	33	1	1	CD
cord-034687-57n88v6t	121	34	R	r	NN
cord-034687-57n88v6t	121	35	in	in	IN
cord-034687-57n88v6t	121	36	cortical	cortical	JJ
cord-034687-57n88v6t	121	37	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	121	38	or	or	CC
cord-034687-57n88v6t	121	39	forebrain	forebrain	JJ
cord-034687-57n88v6t	121	40	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	121	41	neurons	neuron	NNS
cord-034687-57n88v6t	121	42	does	do	VBZ
cord-034687-57n88v6t	121	43	not	not	RB
cord-034687-57n88v6t	121	44	affect	affect	VB
cord-034687-57n88v6t	121	45	the	the	DT
cord-034687-57n88v6t	121	46	memory	memory	NN
cord-034687-57n88v6t	121	47	of	of	IN
cord-034687-57n88v6t	121	48	the	the	DT
cord-034687-57n88v6t	121	49	conditioning	conditioning	NN
cord-034687-57n88v6t	121	50	event	event	NN
cord-034687-57n88v6t	121	51	,	,	,
cord-034687-57n88v6t	121	52	but	but	CC
cord-034687-57n88v6t	121	53	determines	determine	VBZ
cord-034687-57n88v6t	121	54	the	the	DT
cord-034687-57n88v6t	121	55	coping	cope	VBG
cord-034687-57n88v6t	121	56	style	style	NN
cord-034687-57n88v6t	121	57	of	of	IN
cord-034687-57n88v6t	121	58	an	an	DT
cord-034687-57n88v6t	121	59	individual	individual	NN
cord-034687-57n88v6t	121	60	toward	toward	IN
cord-034687-57n88v6t	121	61	the	the	DT
cord-034687-57n88v6t	121	62	threat	threat	NN
cord-034687-57n88v6t	121	63	.	.	.
cord-034687-57n88v6t	122	1	5	5	LS
cord-034687-57n88v6t	122	2	Stress	stress	NN
cord-034687-57n88v6t	122	3	is	be	VBZ
cord-034687-57n88v6t	122	4	an	an	DT
cord-034687-57n88v6t	122	5	alteration	alteration	NN
cord-034687-57n88v6t	122	6	of	of	IN
cord-034687-57n88v6t	122	7	homeostasis	homeostasis	NN
cord-034687-57n88v6t	122	8	as	as	IN
cord-034687-57n88v6t	122	9	a	a	DT
cord-034687-57n88v6t	122	10	consequence	consequence	NN
cord-034687-57n88v6t	122	11	of	of	IN
cord-034687-57n88v6t	122	12	external	external	JJ
cord-034687-57n88v6t	122	13	or	or	CC
cord-034687-57n88v6t	122	14	internal	internal	JJ
cord-034687-57n88v6t	122	15	threats	threat	NNS
cord-034687-57n88v6t	122	16	.	.	.
cord-034687-57n88v6t	123	1	Indeed	indeed	RB
cord-034687-57n88v6t	123	2	,	,	,
cord-034687-57n88v6t	123	3	acute	acute	JJ
cord-034687-57n88v6t	123	4	stressors	stressor	NNS
cord-034687-57n88v6t	123	5	elicit	elicit	VBP
cord-034687-57n88v6t	123	6	immediate	immediate	JJ
cord-034687-57n88v6t	123	7	and	and	CC
cord-034687-57n88v6t	123	8	protracted	protracted	JJ
cord-034687-57n88v6t	123	9	neuroendocrine	neuroendocrine	JJ
cord-034687-57n88v6t	123	10	responses	response	NNS
cord-034687-57n88v6t	123	11	with	with	IN
cord-034687-57n88v6t	123	12	protective	protective	JJ
cord-034687-57n88v6t	123	13	effects	effect	NNS
cord-034687-57n88v6t	123	14	.	.	.
cord-034687-57n88v6t	124	1	These	these	DT
cord-034687-57n88v6t	124	2	responses	response	NNS
cord-034687-57n88v6t	124	3	involve	involve	VBP
cord-034687-57n88v6t	124	4	the	the	DT
cord-034687-57n88v6t	124	5	activation	activation	NN
cord-034687-57n88v6t	124	6	of	of	IN
cord-034687-57n88v6t	124	7	the	the	DT
cord-034687-57n88v6t	124	8	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	124	9	nervous	nervous	JJ
cord-034687-57n88v6t	124	10	system	system	NN
cord-034687-57n88v6t	124	11	and	and	CC
cord-034687-57n88v6t	124	12	the	the	DT
cord-034687-57n88v6t	124	13	HPA	HPA	NNP
cord-034687-57n88v6t	124	14	axis	axis	NN
cord-034687-57n88v6t	124	15	.	.	.
cord-034687-57n88v6t	125	1	Within	within	IN
cord-034687-57n88v6t	125	2	seconds	second	NNS
cord-034687-57n88v6t	125	3	of	of	IN
cord-034687-57n88v6t	125	4	stress	stress	NN
cord-034687-57n88v6t	125	5	exposure	exposure	NN
cord-034687-57n88v6t	125	6	,	,	,
cord-034687-57n88v6t	125	7	noradrenaline	noradrenaline	NN
cord-034687-57n88v6t	125	8	and	and	CC
cord-034687-57n88v6t	125	9	adrenaline	adrenaline	NN
cord-034687-57n88v6t	125	10	are	be	VBP
cord-034687-57n88v6t	125	11	released	release	VBN
cord-034687-57n88v6t	125	12	through	through	IN
cord-034687-57n88v6t	125	13	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	125	14	postganglionic	postganglionic	JJ
cord-034687-57n88v6t	125	15	neurons	neuron	NNS
cord-034687-57n88v6t	125	16	and	and	CC
cord-034687-57n88v6t	125	17	adrenal	adrenal	JJ
cord-034687-57n88v6t	125	18	gland	gland	NN
cord-034687-57n88v6t	125	19	chromaffin	chromaffin	NNP
cord-034687-57n88v6t	125	20	cells	cell	NNS
cord-034687-57n88v6t	125	21	contributing	contribute	VBG
cord-034687-57n88v6t	125	22	to	to	TO
cord-034687-57n88v6t	125	23	fight	fight	VB
cord-034687-57n88v6t	125	24	-	-	HYPH
cord-034687-57n88v6t	125	25	orescape	orescape	NN
cord-034687-57n88v6t	125	26	protective	protective	JJ
cord-034687-57n88v6t	125	27	responses	response	NNS
cord-034687-57n88v6t	125	28	.	.	.
cord-034687-57n88v6t	126	1	In	in	IN
cord-034687-57n88v6t	126	2	parallel	parallel	NN
cord-034687-57n88v6t	126	3	,	,	,
cord-034687-57n88v6t	126	4	the	the	DT
cord-034687-57n88v6t	126	5	HPA	HPA	NNP
cord-034687-57n88v6t	126	6	axis	axis	NN
cord-034687-57n88v6t	126	7	is	be	VBZ
cord-034687-57n88v6t	126	8	activated	activate	VBN
cord-034687-57n88v6t	126	9	through	through	IN
cord-034687-57n88v6t	126	10	CRH	CRH	NNP
cord-034687-57n88v6t	126	11	release	release	NN
cord-034687-57n88v6t	126	12	from	from	IN
cord-034687-57n88v6t	126	13	the	the	DT
cord-034687-57n88v6t	126	14	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	126	15	,	,	,
cord-034687-57n88v6t	126	16	which	which	WDT
cord-034687-57n88v6t	126	17	leads	lead	VBZ
cord-034687-57n88v6t	126	18	to	to	IN
cord-034687-57n88v6t	126	19	ACTH	ACTH	NNP
cord-034687-57n88v6t	126	20	release	release	NN
cord-034687-57n88v6t	126	21	from	from	IN
cord-034687-57n88v6t	126	22	the	the	DT
cord-034687-57n88v6t	126	23	pituitary	pituitary	JJ
cord-034687-57n88v6t	126	24	gland	gland	NN
cord-034687-57n88v6t	126	25	.	.	.
cord-034687-57n88v6t	127	1	ACTH	ACTH	NNP
cord-034687-57n88v6t	127	2	in	in	IN
cord-034687-57n88v6t	127	3	the	the	DT
cord-034687-57n88v6t	127	4	general	general	JJ
cord-034687-57n88v6t	127	5	blood	blood	NN
cord-034687-57n88v6t	127	6	stream	stream	NN
cord-034687-57n88v6t	127	7	reaches	reach	VBZ
cord-034687-57n88v6t	127	8	adrenal	adrenal	JJ
cord-034687-57n88v6t	127	9	glands	gland	NNS
cord-034687-57n88v6t	127	10	that	that	WDT
cord-034687-57n88v6t	127	11	pour	pour	VBP
cord-034687-57n88v6t	127	12	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	127	13	into	into	IN
cord-034687-57n88v6t	127	14	the	the	DT
cord-034687-57n88v6t	127	15	blood	blood	NN
cord-034687-57n88v6t	127	16	circulatory	circulatory	JJ
cord-034687-57n88v6t	127	17	system	system	NN
cord-034687-57n88v6t	127	18	.	.	.
cord-034687-57n88v6t	128	1	These	these	DT
cord-034687-57n88v6t	128	2	corticoids	corticoid	NNS
cord-034687-57n88v6t	128	3	activate	activate	VBP
cord-034687-57n88v6t	128	4	glucocorticoid	glucocorticoid	NN
cord-034687-57n88v6t	128	5	receptors	receptor	NNS
cord-034687-57n88v6t	128	6	that	that	WDT
cord-034687-57n88v6t	128	7	increase	increase	VBP
cord-034687-57n88v6t	128	8	glucose	glucose	NN
cord-034687-57n88v6t	128	9	availability	availability	NN
cord-034687-57n88v6t	128	10	and	and	CC
cord-034687-57n88v6t	128	11	trigger	trigger	NN
cord-034687-57n88v6t	128	12	transcriptional	transcriptional	JJ
cord-034687-57n88v6t	128	13	changes	change	NNS
cord-034687-57n88v6t	128	14	partly	partly	RB
cord-034687-57n88v6t	128	15	directed	direct	VBN
cord-034687-57n88v6t	128	16	to	to	TO
cord-034687-57n88v6t	128	17	limit	limit	VB
cord-034687-57n88v6t	128	18	inflammation	inflammation	NN
cord-034687-57n88v6t	128	19	and	and	CC
cord-034687-57n88v6t	128	20	repair	repair	NN
cord-034687-57n88v6t	128	21	processes	process	NNS
cord-034687-57n88v6t	128	22	that	that	WDT
cord-034687-57n88v6t	128	23	can	can	MD
cord-034687-57n88v6t	128	24	be	be	VB
cord-034687-57n88v6t	128	25	postponed	postpone	VBN
cord-034687-57n88v6t	128	26	.	.	.
cord-034687-57n88v6t	129	1	The	the	DT
cord-034687-57n88v6t	129	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	129	3	system	system	NN
cord-034687-57n88v6t	129	4	present	present	JJ
cord-034687-57n88v6t	129	5	in	in	IN
cord-034687-57n88v6t	129	6	the	the	DT
cord-034687-57n88v6t	129	7	HPA	HPA	NNP
cord-034687-57n88v6t	129	8	axis	axis	NN
cord-034687-57n88v6t	129	9	and	and	CC
cord-034687-57n88v6t	129	10	the	the	DT
cord-034687-57n88v6t	129	11	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	129	12	nervous	nervous	JJ
cord-034687-57n88v6t	129	13	system	system	NN
cord-034687-57n88v6t	129	14	plays	play	VBZ
cord-034687-57n88v6t	129	15	a	a	DT
cord-034687-57n88v6t	129	16	crucial	crucial	JJ
cord-034687-57n88v6t	129	17	role	role	NN
cord-034687-57n88v6t	129	18	in	in	IN
cord-034687-57n88v6t	129	19	regulating	regulate	VBG
cord-034687-57n88v6t	129	20	stress	stress	NN
cord-034687-57n88v6t	129	21	responses	response	NNS
cord-034687-57n88v6t	129	22	(	(	-LRB-
cord-034687-57n88v6t	129	23	Figure	figure	NN
cord-034687-57n88v6t	129	24	3	3	CD
cord-034687-57n88v6t	129	25	)	)	-RRB-
cord-034687-57n88v6t	129	26	.	.	.
cord-034687-57n88v6t	130	1	Early	early	JJ
cord-034687-57n88v6t	130	2	studies	study	NNS
cord-034687-57n88v6t	130	3	showed	show	VBD
cord-034687-57n88v6t	130	4	that	that	IN
cord-034687-57n88v6t	130	5	repeated	repeat	VBN
cord-034687-57n88v6t	130	6	THC	thc	NN
cord-034687-57n88v6t	130	7	modified	modify	VBN
cord-034687-57n88v6t	130	8	dopamine	dopamine	NN
cord-034687-57n88v6t	130	9	b	b	NN
cord-034687-57n88v6t	130	10	-	-	HYPH
cord-034687-57n88v6t	130	11	hydroxylase	hydroxylase	NN
cord-034687-57n88v6t	130	12	activity	activity	NN
cord-034687-57n88v6t	130	13	in	in	IN
cord-034687-57n88v6t	130	14	rodent	rodent	NN
cord-034687-57n88v6t	130	15	serum	serum	NN
cord-034687-57n88v6t	130	16	,	,	,
cord-034687-57n88v6t	130	17	a	a	DT
cord-034687-57n88v6t	130	18	measure	measure	NN
cord-034687-57n88v6t	130	19	of	of	IN
cord-034687-57n88v6t	130	20	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	130	21	system	system	NN
cord-034687-57n88v6t	130	22	activation	activation	NN
cord-034687-57n88v6t	130	23	.	.	.
cord-034687-57n88v6t	131	1	19	19	CD
cord-034687-57n88v6t	132	1	This	this	DT
cord-034687-57n88v6t	132	2	effect	effect	NN
cord-034687-57n88v6t	132	3	was	be	VBD
cord-034687-57n88v6t	132	4	different	different	JJ
cord-034687-57n88v6t	132	5	depending	depend	VBG
cord-034687-57n88v6t	132	6	on	on	IN
cord-034687-57n88v6t	132	7	the	the	DT
cord-034687-57n88v6t	132	8	basal	basal	NN
cord-034687-57n88v6t	132	9	status	status	NN
cord-034687-57n88v6t	132	10	of	of	IN
cord-034687-57n88v6t	132	11	exposed	expose	VBN
cord-034687-57n88v6t	132	12	subjects	subject	NNS
cord-034687-57n88v6t	132	13	revealing	reveal	VBG
cord-034687-57n88v6t	132	14	a	a	DT
cord-034687-57n88v6t	132	15	complex	complex	JJ
cord-034687-57n88v6t	132	16	modulatory	modulatory	JJ
cord-034687-57n88v6t	132	17	role	role	NN
cord-034687-57n88v6t	132	18	of	of	IN
cord-034687-57n88v6t	132	19	the	the	DT
cord-034687-57n88v6t	132	20	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	132	21	system	system	NN
cord-034687-57n88v6t	132	22	:	:	:
cord-034687-57n88v6t	132	23	THC	thc	NN
cord-034687-57n88v6t	132	24	alleviated	alleviate	VBN
cord-034687-57n88v6t	132	25	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	132	26	activation	activation	NN
cord-034687-57n88v6t	132	27	in	in	IN
cord-034687-57n88v6t	132	28	naive	naive	JJ
cord-034687-57n88v6t	132	29	mice	mouse	NNS
cord-034687-57n88v6t	132	30	but	but	CC
cord-034687-57n88v6t	132	31	potentiated	potentiate	VBD
cord-034687-57n88v6t	132	32	this	this	DT
cord-034687-57n88v6t	132	33	response	response	NN
cord-034687-57n88v6t	132	34	in	in	IN
cord-034687-57n88v6t	132	35	rodents	rodent	NNS
cord-034687-57n88v6t	132	36	subjected	subject	VBN
cord-034687-57n88v6t	132	37	to	to	IN
cord-034687-57n88v6t	132	38	immobilization	immobilization	NN
cord-034687-57n88v6t	132	39	stress	stress	NN
cord-034687-57n88v6t	132	40	.	.	.
cord-034687-57n88v6t	133	1	CB	CB	NNP
cord-034687-57n88v6t	133	2	1	1	CD
cord-034687-57n88v6t	133	3	R	r	NN
cord-034687-57n88v6t	133	4	controls	control	VBZ
cord-034687-57n88v6t	133	5	peripheral	peripheral	JJ
cord-034687-57n88v6t	133	6	and	and	CC
cord-034687-57n88v6t	133	7	central	central	JJ
cord-034687-57n88v6t	133	8	adrenaline	adrenaline	NN
cord-034687-57n88v6t	133	9	,	,	,
cord-034687-57n88v6t	133	10	and	and	CC
cord-034687-57n88v6t	133	11	noradrenaline	noradrenaline	NN
cord-034687-57n88v6t	133	12	release	release	NN
cord-034687-57n88v6t	133	13	involved	involve	VBN
cord-034687-57n88v6t	133	14	in	in	IN
cord-034687-57n88v6t	133	15	stress	stress	NN
cord-034687-57n88v6t	133	16	-	-	HYPH
cord-034687-57n88v6t	133	17	induced	induce	VBN
cord-034687-57n88v6t	133	18	memory	memory	NN
cord-034687-57n88v6t	133	19	impairment	impairment	NN
cord-034687-57n88v6t	133	20	,	,	,
cord-034687-57n88v6t	133	21	20	20	CD
cord-034687-57n88v6t	133	22	and	and	CC
cord-034687-57n88v6t	133	23	the	the	DT
cord-034687-57n88v6t	133	24	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	133	25	nervous	nervous	JJ
cord-034687-57n88v6t	133	26	system	system	NN
cord-034687-57n88v6t	133	27	partly	partly	RB
cord-034687-57n88v6t	133	28	mediates	mediate	VBZ
cord-034687-57n88v6t	133	29	the	the	DT
cord-034687-57n88v6t	133	30	anxiety	anxiety	NN
cord-034687-57n88v6t	133	31	-	-	HYPH
cord-034687-57n88v6t	133	32	like	like	JJ
cord-034687-57n88v6t	133	33	effects	effect	NNS
cord-034687-57n88v6t	133	34	observed	observe	VBN
cord-034687-57n88v6t	133	35	after	after	IN
cord-034687-57n88v6t	133	36	CB	CB	NNP
cord-034687-57n88v6t	133	37	1	1	CD
cord-034687-57n88v6t	133	38	R	r	NN
cord-034687-57n88v6t	133	39	blockade	blockade	NN
cord-034687-57n88v6t	133	40	.	.	.
cord-034687-57n88v6t	134	1	21	21	CD
cord-034687-57n88v6t	135	1	In	in	IN
cord-034687-57n88v6t	135	2	regard	regard	NN
cord-034687-57n88v6t	135	3	to	to	IN
cord-034687-57n88v6t	135	4	the	the	DT
cord-034687-57n88v6t	135	5	HPA	HPA	NNP
cord-034687-57n88v6t	135	6	axis	axis	NN
cord-034687-57n88v6t	135	7	,	,	,
cord-034687-57n88v6t	135	8	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	135	9	and	and	CC
cord-034687-57n88v6t	135	10	knockout	knockout	NN
cord-034687-57n88v6t	135	11	studies	study	NNS
cord-034687-57n88v6t	135	12	demonstrate	demonstrate	VBP
cord-034687-57n88v6t	135	13	that	that	IN
cord-034687-57n88v6t	135	14	CB	CB	NNP
cord-034687-57n88v6t	135	15	1	1	CD
cord-034687-57n88v6t	135	16	R	r	NN
cord-034687-57n88v6t	135	17	activity	activity	NN
cord-034687-57n88v6t	135	18	limits	limit	VBZ
cord-034687-57n88v6t	135	19	hypothalamic	hypothalamic	JJ
cord-034687-57n88v6t	135	20	CRH	CRH	NNP
cord-034687-57n88v6t	135	21	release	release	NN
cord-034687-57n88v6t	135	22	.	.	.
cord-034687-57n88v6t	136	1	22	22	CD
cord-034687-57n88v6t	136	2	CB	cb	NN
cord-034687-57n88v6t	136	3	1	1	CD
cord-034687-57n88v6t	136	4	R	r	NN
cord-034687-57n88v6t	136	5	is	be	VBZ
cord-034687-57n88v6t	136	6	also	also	RB
cord-034687-57n88v6t	136	7	present	present	JJ
cord-034687-57n88v6t	136	8	in	in	IN
cord-034687-57n88v6t	136	9	the	the	DT
cord-034687-57n88v6t	136	10	pituitary	pituitary	JJ
cord-034687-57n88v6t	136	11	gland	gland	NN
cord-034687-57n88v6t	136	12	and	and	CC
cord-034687-57n88v6t	136	13	adrenal	adrenal	JJ
cord-034687-57n88v6t	136	14	cortex	cortex	NN
cord-034687-57n88v6t	136	15	cells	cell	NNS
cord-034687-57n88v6t	136	16	,	,	,
cord-034687-57n88v6t	136	17	where	where	WRB
cord-034687-57n88v6t	136	18	it	-PRON-	PRP
cord-034687-57n88v6t	136	19	restricts	restrict	VBZ
cord-034687-57n88v6t	136	20	ACTH	ACTH	NNP
cord-034687-57n88v6t	136	21	and	and	CC
cord-034687-57n88v6t	136	22	glucocorticoid	glucocorticoid	NN
cord-034687-57n88v6t	136	23	release	release	NN
cord-034687-57n88v6t	136	24	,	,	,
cord-034687-57n88v6t	136	25	respectively	respectively	RB
cord-034687-57n88v6t	136	26	.	.	.
cord-034687-57n88v6t	137	1	22	22	CD
cord-034687-57n88v6t	138	1	On	on	IN
cord-034687-57n88v6t	138	2	the	the	DT
cord-034687-57n88v6t	138	3	contrary	contrary	NN
cord-034687-57n88v6t	138	4	,	,	,
cord-034687-57n88v6t	138	5	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	138	6	induce	induce	VBP
cord-034687-57n88v6t	138	7	fast	fast	JJ
cord-034687-57n88v6t	138	8	increases	increase	NNS
cord-034687-57n88v6t	138	9	in	in	IN
cord-034687-57n88v6t	138	10	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	138	11	synthesis	synthesis	NN
cord-034687-57n88v6t	138	12	in	in	IN
cord-034687-57n88v6t	138	13	brain	brain	NN
cord-034687-57n88v6t	138	14	areas	area	NNS
cord-034687-57n88v6t	138	15	that	that	WDT
cord-034687-57n88v6t	138	16	shape	shape	VBP
cord-034687-57n88v6t	138	17	the	the	DT
cord-034687-57n88v6t	138	18	perception	perception	NN
cord-034687-57n88v6t	138	19	of	of	IN
cord-034687-57n88v6t	138	20	psychological	psychological	JJ
cord-034687-57n88v6t	138	21	stressors	stressor	NNS
cord-034687-57n88v6t	138	22	.	.	.
cord-034687-57n88v6t	139	1	23	23	CD
cord-034687-57n88v6t	140	1	These	these	DT
cord-034687-57n88v6t	140	2	regions	region	NNS
cord-034687-57n88v6t	140	3	include	include	VBP
cord-034687-57n88v6t	140	4	areas	area	NNS
cord-034687-57n88v6t	140	5	involved	involve	VBN
cord-034687-57n88v6t	140	6	in	in	IN
cord-034687-57n88v6t	140	7	cognitive	cognitive	JJ
cord-034687-57n88v6t	140	8	processes	process	NNS
cord-034687-57n88v6t	140	9	such	such	JJ
cord-034687-57n88v6t	140	10	as	as	IN
cord-034687-57n88v6t	140	11	PFC	PFC	NNP
cord-034687-57n88v6t	140	12	and	and	CC
cord-034687-57n88v6t	140	13	hippocampus	hippocampus	NN
cord-034687-57n88v6t	140	14	,	,	,
cord-034687-57n88v6t	140	15	and	and	CC
cord-034687-57n88v6t	140	16	areas	area	NNS
cord-034687-57n88v6t	140	17	related	relate	VBN
cord-034687-57n88v6t	140	18	with	with	IN
cord-034687-57n88v6t	140	19	affective	affective	JJ
cord-034687-57n88v6t	140	20	responses	response	NNS
cord-034687-57n88v6t	140	21	such	such	JJ
cord-034687-57n88v6t	140	22	as	as	IN
cord-034687-57n88v6t	140	23	the	the	DT
cord-034687-57n88v6t	140	24	amygdala	amygdala	NN
cord-034687-57n88v6t	140	25	.	.	.
cord-034687-57n88v6t	141	1	24	24	CD
cord-034687-57n88v6t	141	2	Glucocorticoids	Glucocorticoids	NNP
cord-034687-57n88v6t	141	3	released	release	VBN
cord-034687-57n88v6t	141	4	after	after	IN
cord-034687-57n88v6t	141	5	acute	acute	JJ
cord-034687-57n88v6t	141	6	stressors	stressor	NNS
cord-034687-57n88v6t	141	7	activate	activate	VBP
cord-034687-57n88v6t	141	8	G	g	NN
cord-034687-57n88v6t	141	9	-	-	HYPH
cord-034687-57n88v6t	141	10	protein	protein	NN
cord-034687-57n88v6t	141	11	membrane	membrane	NN
cord-034687-57n88v6t	141	12	receptors	receptor	NNS
cord-034687-57n88v6t	141	13	in	in	IN
cord-034687-57n88v6t	141	14	the	the	DT
cord-034687-57n88v6t	141	15	BLA	BLA	NNP
cord-034687-57n88v6t	141	16	,	,	,
cord-034687-57n88v6t	141	17	promoting	promote	VBG
cord-034687-57n88v6t	141	18	a	a	DT
cord-034687-57n88v6t	141	19	rapid	rapid	JJ
cord-034687-57n88v6t	141	20	increase	increase	NN
cord-034687-57n88v6t	141	21	in	in	IN
cord-034687-57n88v6t	141	22	retrograde	retrograde	JJ
cord-034687-57n88v6t	141	23	2-AG	2-ag	CD
cord-034687-57n88v6t	141	24	signaling	signaling	NN
cord-034687-57n88v6t	141	25	that	that	WDT
cord-034687-57n88v6t	141	26	leads	lead	VBZ
cord-034687-57n88v6t	141	27	to	to	IN
cord-034687-57n88v6t	141	28	suppression	suppression	NN
cord-034687-57n88v6t	141	29	of	of	IN
cord-034687-57n88v6t	141	30	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	141	31	synaptic	synaptic	JJ
cord-034687-57n88v6t	141	32	inputs	input	NNS
cord-034687-57n88v6t	141	33	onto	onto	IN
cord-034687-57n88v6t	141	34	BLA	BLA	NNP
cord-034687-57n88v6t	141	35	principal	principal	JJ
cord-034687-57n88v6t	141	36	neurons	neuron	NNS
cord-034687-57n88v6t	141	37	,	,	,
cord-034687-57n88v6t	141	38	inducing	induce	VBG
cord-034687-57n88v6t	141	39	fast	fast	JJ
cord-034687-57n88v6t	141	40	increases	increase	NNS
cord-034687-57n88v6t	141	41	in	in	IN
cord-034687-57n88v6t	141	42	anxiety	anxiety	NN
cord-034687-57n88v6t	141	43	-	-	HYPH
cord-034687-57n88v6t	141	44	like	like	JJ
cord-034687-57n88v6t	141	45	behavior	behavior	NN
cord-034687-57n88v6t	141	46	.	.	.
cord-034687-57n88v6t	142	1	25	25	CD
cord-034687-57n88v6t	143	1	These	these	DT
cord-034687-57n88v6t	143	2	limbic	limbic	JJ
cord-034687-57n88v6t	143	3	areas	area	NNS
cord-034687-57n88v6t	143	4	are	be	VBP
cord-034687-57n88v6t	143	5	further	further	RB
cord-034687-57n88v6t	143	6	connected	connect	VBN
cord-034687-57n88v6t	143	7	with	with	IN
cord-034687-57n88v6t	143	8	the	the	DT
cord-034687-57n88v6t	143	9	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	143	10	to	to	TO
cord-034687-57n88v6t	143	11	modulate	modulate	VB
cord-034687-57n88v6t	143	12	Under	under	IN
cord-034687-57n88v6t	143	13	stress	stress	NN
cord-034687-57n88v6t	143	14	conditions	condition	NNS
cord-034687-57n88v6t	143	15	,	,	,
cord-034687-57n88v6t	143	16	the	the	DT
cord-034687-57n88v6t	143	17	HPA	HPA	NNP
cord-034687-57n88v6t	143	18	axis	axis	NN
cord-034687-57n88v6t	143	19	is	be	VBZ
cord-034687-57n88v6t	143	20	activated	activate	VBN
cord-034687-57n88v6t	143	21	to	to	TO
cord-034687-57n88v6t	143	22	produce	produce	VB
cord-034687-57n88v6t	143	23	an	an	DT
cord-034687-57n88v6t	143	24	adaptive	adaptive	JJ
cord-034687-57n88v6t	143	25	defensive	defensive	JJ
cord-034687-57n88v6t	143	26	response	response	NN
cord-034687-57n88v6t	143	27	to	to	IN
cord-034687-57n88v6t	143	28	stress	stress	NN
cord-034687-57n88v6t	143	29	.	.	.
cord-034687-57n88v6t	144	1	To	to	TO
cord-034687-57n88v6t	144	2	counteract	counteract	VB
cord-034687-57n88v6t	144	3	excessive	excessive	JJ
cord-034687-57n88v6t	144	4	HPA	hpa	NN
cord-034687-57n88v6t	144	5	-	-	HYPH
cord-034687-57n88v6t	144	6	axis	axis	NN
cord-034687-57n88v6t	144	7	activation	activation	NN
cord-034687-57n88v6t	144	8	,	,	,
cord-034687-57n88v6t	144	9	CB	CB	NNP
cord-034687-57n88v6t	144	10	1	1	CD
cord-034687-57n88v6t	144	11	R	r	NN
cord-034687-57n88v6t	144	12	activity	activity	NN
cord-034687-57n88v6t	144	13	limits	limit	VBZ
cord-034687-57n88v6t	144	14	the	the	DT
cord-034687-57n88v6t	144	15	release	release	NN
cord-034687-57n88v6t	144	16	of	of	IN
cord-034687-57n88v6t	144	17	hypothalamic	hypothalamic	JJ
cord-034687-57n88v6t	144	18	corticotropin	corticotropin	NNP
cord-034687-57n88v6t	144	19	-	-	HYPH
cord-034687-57n88v6t	144	20	releasing	release	VBG
cord-034687-57n88v6t	144	21	hormone	hormone	NN
cord-034687-57n88v6t	144	22	.	.	.
cord-034687-57n88v6t	145	1	CB	CB	NNP
cord-034687-57n88v6t	145	2	1	1	CD
cord-034687-57n88v6t	145	3	R	r	NN
cord-034687-57n88v6t	145	4	is	be	VBZ
cord-034687-57n88v6t	145	5	also	also	RB
cord-034687-57n88v6t	145	6	present	present	JJ
cord-034687-57n88v6t	145	7	in	in	IN
cord-034687-57n88v6t	145	8	the	the	DT
cord-034687-57n88v6t	145	9	pituitary	pituitary	JJ
cord-034687-57n88v6t	145	10	gland	gland	NN
cord-034687-57n88v6t	145	11	and	and	CC
cord-034687-57n88v6t	145	12	adrenal	adrenal	JJ
cord-034687-57n88v6t	145	13	cortex	cortex	NN
cord-034687-57n88v6t	145	14	cells	cell	NNS
cord-034687-57n88v6t	145	15	,	,	,
cord-034687-57n88v6t	145	16	where	where	WRB
cord-034687-57n88v6t	145	17	they	-PRON-	PRP
cord-034687-57n88v6t	145	18	restrict	restrict	VBP
cord-034687-57n88v6t	145	19	adrenocorticotropin	adrenocorticotropin	JJ
cord-034687-57n88v6t	145	20	hormone	hormone	NN
cord-034687-57n88v6t	145	21	and	and	CC
cord-034687-57n88v6t	145	22	glucocorticoid	glucocorticoid	NN
cord-034687-57n88v6t	145	23	release	release	NN
cord-034687-57n88v6t	145	24	,	,	,
cord-034687-57n88v6t	145	25	respectively	respectively	RB
cord-034687-57n88v6t	145	26	.	.	.
cord-034687-57n88v6t	146	1	On	on	IN
cord-034687-57n88v6t	146	2	the	the	DT
cord-034687-57n88v6t	146	3	contrary	contrary	NN
cord-034687-57n88v6t	146	4	,	,	,
cord-034687-57n88v6t	146	5	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	146	6	induce	induce	VBP
cord-034687-57n88v6t	146	7	fast	fast	JJ
cord-034687-57n88v6t	146	8	increases	increase	NNS
cord-034687-57n88v6t	146	9	in	in	IN
cord-034687-57n88v6t	146	10	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	146	11	synthesis	synthesis	NN
cord-034687-57n88v6t	146	12	in	in	IN
cord-034687-57n88v6t	146	13	brain	brain	NN
cord-034687-57n88v6t	146	14	areas	area	NNS
cord-034687-57n88v6t	146	15	that	that	WDT
cord-034687-57n88v6t	146	16	shape	shape	VBP
cord-034687-57n88v6t	146	17	the	the	DT
cord-034687-57n88v6t	146	18	perception	perception	NN
cord-034687-57n88v6t	146	19	of	of	IN
cord-034687-57n88v6t	146	20	stress	stress	NN
cord-034687-57n88v6t	146	21	.	.	.
cord-034687-57n88v6t	147	1	These	these	DT
cord-034687-57n88v6t	147	2	regions	region	NNS
cord-034687-57n88v6t	147	3	include	include	VBP
cord-034687-57n88v6t	147	4	the	the	DT
cord-034687-57n88v6t	147	5	prefrontal	prefrontal	NNP
cord-034687-57n88v6t	147	6	cortex	cortex	NNP
cord-034687-57n88v6t	147	7	,	,	,
cord-034687-57n88v6t	147	8	the	the	DT
cord-034687-57n88v6t	147	9	hippocampus	hippocampus	NN
cord-034687-57n88v6t	147	10	,	,	,
cord-034687-57n88v6t	147	11	and	and	CC
cord-034687-57n88v6t	147	12	the	the	DT
cord-034687-57n88v6t	147	13	amygdala	amygdala	NN
cord-034687-57n88v6t	147	14	.	.	.
cord-034687-57n88v6t	148	1	Indeed	indeed	RB
cord-034687-57n88v6t	148	2	,	,	,
cord-034687-57n88v6t	148	3	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	148	4	released	release	VBN
cord-034687-57n88v6t	148	5	after	after	IN
cord-034687-57n88v6t	148	6	acute	acute	JJ
cord-034687-57n88v6t	148	7	stressors	stressor	NNS
cord-034687-57n88v6t	148	8	promote	promote	VBP
cord-034687-57n88v6t	148	9	a	a	DT
cord-034687-57n88v6t	148	10	rapid	rapid	JJ
cord-034687-57n88v6t	148	11	increase	increase	NN
cord-034687-57n88v6t	148	12	in	in	IN
cord-034687-57n88v6t	148	13	retrograde	retrograde	JJ
cord-034687-57n88v6t	148	14	2-arachidonoylglycerol	2-arachidonoylglycerol	CD
cord-034687-57n88v6t	149	1	(	(	-LRB-
cord-034687-57n88v6t	149	2	2-AG	2-ag	CD
cord-034687-57n88v6t	149	3	)	)	-RRB-
cord-034687-57n88v6t	149	4	signaling	signal	VBG
cord-034687-57n88v6t	149	5	in	in	IN
cord-034687-57n88v6t	149	6	these	these	DT
cord-034687-57n88v6t	149	7	brain	brain	NN
cord-034687-57n88v6t	149	8	areas	area	NNS
cord-034687-57n88v6t	149	9	leading	lead	VBG
cord-034687-57n88v6t	149	10	to	to	IN
cord-034687-57n88v6t	149	11	decreased	decrease	VBN
cord-034687-57n88v6t	149	12	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	149	13	release	release	NN
cord-034687-57n88v6t	149	14	in	in	IN
cord-034687-57n88v6t	149	15	the	the	DT
cord-034687-57n88v6t	149	16	amygdala	amygdala	NN
cord-034687-57n88v6t	149	17	that	that	WDT
cord-034687-57n88v6t	149	18	induces	induce	VBZ
cord-034687-57n88v6t	149	19	a	a	DT
cord-034687-57n88v6t	149	20	fast	fast	JJ
cord-034687-57n88v6t	149	21	increase	increase	NN
cord-034687-57n88v6t	149	22	in	in	IN
cord-034687-57n88v6t	149	23	anxiety	anxiety	NN
cord-034687-57n88v6t	149	24	-	-	HYPH
cord-034687-57n88v6t	149	25	like	like	JJ
cord-034687-57n88v6t	149	26	behavior	behavior	NN
cord-034687-57n88v6t	149	27	.	.	.
cord-034687-57n88v6t	150	1	Original	original	JJ
cord-034687-57n88v6t	150	2	article	article	NN
cord-034687-57n88v6t	151	1	The	the	DT
cord-034687-57n88v6t	151	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	151	3	system	system	NN
cord-034687-57n88v6t	151	4	in	in	IN
cord-034687-57n88v6t	151	5	fear	fear	NN
cord-034687-57n88v6t	151	6	,	,	,
cord-034687-57n88v6t	151	7	anxiety	anxiety	NN
cord-034687-57n88v6t	151	8	,	,	,
cord-034687-57n88v6t	151	9	and	and	CC
cord-034687-57n88v6t	151	10	stress	stress	NN
cord-034687-57n88v6t	151	11	-Maldonado	-maldonado	NN
cord-034687-57n88v6t	151	12	et	et	FW
cord-034687-57n88v6t	151	13	al	al	NNP
cord-034687-57n88v6t	151	14	stress	stress	NN
cord-034687-57n88v6t	151	15	responses	response	NNS
cord-034687-57n88v6t	151	16	(	(	-LRB-
cord-034687-57n88v6t	151	17	Figure	figure	NN
cord-034687-57n88v6t	151	18	3	3	CD
cord-034687-57n88v6t	151	19	)	)	-RRB-
cord-034687-57n88v6t	151	20	.	.	.
cord-034687-57n88v6t	152	1	CB	CB	NNP
cord-034687-57n88v6t	152	2	1	1	CD
cord-034687-57n88v6t	152	3	R	r	NN
cord-034687-57n88v6t	152	4	located	locate	VBN
cord-034687-57n88v6t	152	5	in	in	IN
cord-034687-57n88v6t	152	6	these	these	DT
cord-034687-57n88v6t	152	7	structures	structure	NNS
cord-034687-57n88v6t	152	8	represent	represent	VBP
cord-034687-57n88v6t	152	9	a	a	DT
cord-034687-57n88v6t	152	10	unique	unique	JJ
cord-034687-57n88v6t	152	11	opportunity	opportunity	NN
cord-034687-57n88v6t	152	12	for	for	IN
cord-034687-57n88v6t	152	13	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	152	14	modulation	modulation	NN
cord-034687-57n88v6t	152	15	.	.	.
cord-034687-57n88v6t	153	1	However	however	RB
cord-034687-57n88v6t	153	2	,	,	,
cord-034687-57n88v6t	153	3	the	the	DT
cord-034687-57n88v6t	153	4	use	use	NN
cord-034687-57n88v6t	153	5	of	of	IN
cord-034687-57n88v6t	153	6	exogenous	exogenous	JJ
cord-034687-57n88v6t	153	7	CB	CB	NNP
cord-034687-57n88v6t	153	8	1	1	CD
cord-034687-57n88v6t	153	9	R	r	NN
cord-034687-57n88v6t	153	10	ligands	ligand	NNS
cord-034687-57n88v6t	153	11	has	have	VBZ
cord-034687-57n88v6t	153	12	been	be	VBN
cord-034687-57n88v6t	153	13	associated	associate	VBN
cord-034687-57n88v6t	153	14	with	with	IN
cord-034687-57n88v6t	153	15	serious	serious	JJ
cord-034687-57n88v6t	153	16	health	health	NN
cord-034687-57n88v6t	153	17	problems	problem	NNS
cord-034687-57n88v6t	153	18	,	,	,
cord-034687-57n88v6t	153	19	from	from	IN
cord-034687-57n88v6t	153	20	THC	thc	NN
cord-034687-57n88v6t	153	21	effects	effect	NNS
cord-034687-57n88v6t	153	22	promoting	promote	VBG
cord-034687-57n88v6t	153	23	addictive	addictive	JJ
cord-034687-57n88v6t	153	24	behaviors	behavior	NNS
cord-034687-57n88v6t	153	25	26	26	CD
cord-034687-57n88v6t	153	26	and	and	CC
cord-034687-57n88v6t	153	27	anxiety	anxiety	NN
cord-034687-57n88v6t	153	28	disorders	disorder	NNS
cord-034687-57n88v6t	153	29	27	27	CD
cord-034687-57n88v6t	153	30	to	to	IN
cord-034687-57n88v6t	153	31	the	the	DT
cord-034687-57n88v6t	153	32	psychiatric	psychiatric	JJ
cord-034687-57n88v6t	153	33	alterations	alteration	NNS
cord-034687-57n88v6t	153	34	(	(	-LRB-
cord-034687-57n88v6t	153	35	anxiety	anxiety	NN
cord-034687-57n88v6t	153	36	,	,	,
cord-034687-57n88v6t	153	37	depression	depression	NN
cord-034687-57n88v6t	153	38	,	,	,
cord-034687-57n88v6t	153	39	or	or	CC
cord-034687-57n88v6t	153	40	suicidal	suicidal	JJ
cord-034687-57n88v6t	153	41	behaviors	behavior	NNS
cord-034687-57n88v6t	153	42	)	)	-RRB-
cord-034687-57n88v6t	153	43	related	relate	VBN
cord-034687-57n88v6t	153	44	to	to	IN
cord-034687-57n88v6t	153	45	the	the	DT
cord-034687-57n88v6t	153	46	CB	CB	NNP
cord-034687-57n88v6t	153	47	1	1	CD
cord-034687-57n88v6t	153	48	R	r	NN
cord-034687-57n88v6t	153	49	inverse	inverse	NN
cord-034687-57n88v6t	153	50	agonist	agonist	NN
cord-034687-57n88v6t	153	51	rimonabant	rimonabant	NN
cord-034687-57n88v6t	153	52	.	.	.
cord-034687-57n88v6t	154	1	28	28	CD
cord-034687-57n88v6t	155	1	Therefore	therefore	RB
cord-034687-57n88v6t	155	2	,	,	,
cord-034687-57n88v6t	155	3	a	a	DT
cord-034687-57n88v6t	155	4	great	great	JJ
cord-034687-57n88v6t	155	5	deal	deal	NN
cord-034687-57n88v6t	155	6	of	of	IN
cord-034687-57n88v6t	155	7	research	research	NN
cord-034687-57n88v6t	155	8	has	have	VBZ
cord-034687-57n88v6t	155	9	focused	focus	VBN
cord-034687-57n88v6t	155	10	on	on	IN
cord-034687-57n88v6t	155	11	the	the	DT
cord-034687-57n88v6t	155	12	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	155	13	modulation	modulation	NN
cord-034687-57n88v6t	155	14	of	of	IN
cord-034687-57n88v6t	155	15	endogenous	endogenous	JJ
cord-034687-57n88v6t	155	16	cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	155	17	as	as	IN
cord-034687-57n88v6t	155	18	an	an	DT
cord-034687-57n88v6t	155	19	alternative	alternative	JJ
cord-034687-57n88v6t	155	20	approach	approach	NN
cord-034687-57n88v6t	155	21	for	for	IN
cord-034687-57n88v6t	155	22	the	the	DT
cord-034687-57n88v6t	155	23	treatment	treatment	NN
cord-034687-57n88v6t	155	24	of	of	IN
cord-034687-57n88v6t	155	25	stress	stress	NN
cord-034687-57n88v6t	155	26	-	-	HYPH
cord-034687-57n88v6t	155	27	induced	induce	VBN
cord-034687-57n88v6t	155	28	alterations	alteration	NNS
cord-034687-57n88v6t	155	29	.	.	.
cord-034687-57n88v6t	156	1	In	in	IN
cord-034687-57n88v6t	156	2	this	this	DT
cord-034687-57n88v6t	156	3	context	context	NN
cord-034687-57n88v6t	156	4	,	,	,
cord-034687-57n88v6t	156	5	the	the	DT
cord-034687-57n88v6t	156	6	enzymes	enzyme	NNS
cord-034687-57n88v6t	156	7	involved	involve	VBN
cord-034687-57n88v6t	156	8	in	in	IN
cord-034687-57n88v6t	156	9	the	the	DT
cord-034687-57n88v6t	156	10	synthesis	synthesis	NN
cord-034687-57n88v6t	156	11	and	and	CC
cord-034687-57n88v6t	156	12	degradation	degradation	NN
cord-034687-57n88v6t	156	13	of	of	IN
cord-034687-57n88v6t	156	14	endocannabinoids	endocannabinoid	NNS
cord-034687-57n88v6t	156	15	represent	represent	VBP
cord-034687-57n88v6t	156	16	potential	potential	JJ
cord-034687-57n88v6t	156	17	effective	effective	JJ
cord-034687-57n88v6t	156	18	targets	target	NNS
cord-034687-57n88v6t	156	19	with	with	IN
cord-034687-57n88v6t	156	20	possible	possible	JJ
cord-034687-57n88v6t	156	21	better	well	JJR
cord-034687-57n88v6t	156	22	safety	safety	NN
cord-034687-57n88v6t	156	23	profiles	profile	NNS
cord-034687-57n88v6t	156	24	than	than	IN
cord-034687-57n88v6t	156	25	drugs	drug	NNS
cord-034687-57n88v6t	156	26	directly	directly	RB
cord-034687-57n88v6t	156	27	acting	act	VBG
cord-034687-57n88v6t	156	28	on	on	IN
cord-034687-57n88v6t	156	29	CB	CB	NNP
cord-034687-57n88v6t	156	30	1	1	CD
cord-034687-57n88v6t	156	31	R.	R.	NNP
cord-034687-57n88v6t	156	32	Models	Models	NNPS
cord-034687-57n88v6t	156	33	of	of	IN
cord-034687-57n88v6t	156	34	acute	acute	JJ
cord-034687-57n88v6t	156	35	immobilization	immobilization	NN
cord-034687-57n88v6t	156	36	stress	stress	NN
cord-034687-57n88v6t	156	37	provoke	provoke	VBP
cord-034687-57n88v6t	156	38	immediate	immediate	JJ
cord-034687-57n88v6t	156	39	increases	increase	NNS
cord-034687-57n88v6t	156	40	in	in	IN
cord-034687-57n88v6t	156	41	FAAH	FAAH	NNP
cord-034687-57n88v6t	156	42	activity	activity	NN
cord-034687-57n88v6t	156	43	,	,	,
cord-034687-57n88v6t	156	44	the	the	DT
cord-034687-57n88v6t	156	45	enzyme	enzyme	NN
cord-034687-57n88v6t	156	46	involved	involve	VBN
cord-034687-57n88v6t	156	47	in	in	IN
cord-034687-57n88v6t	156	48	anandamide	anandamide	NN
cord-034687-57n88v6t	156	49	degradation	degradation	NN
cord-034687-57n88v6t	156	50	,	,	,
cord-034687-57n88v6t	156	51	in	in	IN
cord-034687-57n88v6t	156	52	amygdala	amygdala	NN
cord-034687-57n88v6t	156	53	and	and	CC
cord-034687-57n88v6t	156	54	hippocampus	hippocampus	NN
cord-034687-57n88v6t	156	55	.	.	.
cord-034687-57n88v6t	157	1	Enhancing	enhance	VBG
cord-034687-57n88v6t	157	2	the	the	DT
cord-034687-57n88v6t	157	3	activity	activity	NN
cord-034687-57n88v6t	157	4	of	of	IN
cord-034687-57n88v6t	157	5	this	this	DT
cord-034687-57n88v6t	157	6	degrading	degrade	VBG
cord-034687-57n88v6t	157	7	enzyme	enzyme	NN
cord-034687-57n88v6t	157	8	results	result	NNS
cord-034687-57n88v6t	157	9	in	in	IN
cord-034687-57n88v6t	157	10	glucocorticoid	glucocorticoid	NN
cord-034687-57n88v6t	157	11	release	release	NN
cord-034687-57n88v6t	157	12	and	and	CC
cord-034687-57n88v6t	157	13	stress	stress	NN
cord-034687-57n88v6t	157	14	-	-	HYPH
cord-034687-57n88v6t	157	15	related	relate	VBN
cord-034687-57n88v6t	157	16	anxiety	anxiety	NN
cord-034687-57n88v6t	157	17	-	-	HYPH
cord-034687-57n88v6t	157	18	like	like	JJ
cord-034687-57n88v6t	157	19	behavior	behavior	NN
cord-034687-57n88v6t	157	20	,	,	,
cord-034687-57n88v6t	157	21	29	29	CD
cord-034687-57n88v6t	157	22	whereas	whereas	IN
cord-034687-57n88v6t	157	23	FAAH	FAAH	NNP
cord-034687-57n88v6t	157	24	inhibition	inhibition	NN
cord-034687-57n88v6t	157	25	or	or	CC
cord-034687-57n88v6t	157	26	costimulation	costimulation	NN
cord-034687-57n88v6t	157	27	of	of	IN
cord-034687-57n88v6t	157	28	CB	CB	NNP
cord-034687-57n88v6t	157	29	1	1	CD
cord-034687-57n88v6t	157	30	R	R	NNP
cord-034687-57n88v6t	157	31	and	and	CC
cord-034687-57n88v6t	157	32	TRPV	TRPV	NNP
cord-034687-57n88v6t	157	33	1	1	CD
cord-034687-57n88v6t	157	34	(	(	-LRB-
cord-034687-57n88v6t	157	35	transient	transient	JJ
cord-034687-57n88v6t	157	36	receptor	receptor	NN
cord-034687-57n88v6t	157	37	potential	potential	JJ
cord-034687-57n88v6t	157	38	cation	cation	NN
cord-034687-57n88v6t	157	39	channel	channel	NN
cord-034687-57n88v6t	157	40	subfamily	subfamily	NN
cord-034687-57n88v6t	157	41	V	V	NNP
cord-034687-57n88v6t	157	42	member	member	NN
cord-034687-57n88v6t	157	43	1	1	CD
cord-034687-57n88v6t	157	44	)	)	-RRB-
cord-034687-57n88v6t	157	45	receptors	receptor	NNS
cord-034687-57n88v6t	157	46	decreases	decrease	VBZ
cord-034687-57n88v6t	157	47	stress	stress	NN
cord-034687-57n88v6t	157	48	-	-	HYPH
cord-034687-57n88v6t	157	49	induced	induce	VBN
cord-034687-57n88v6t	157	50	corticoid	corticoid	NN
cord-034687-57n88v6t	157	51	release	release	NN
cord-034687-57n88v6t	157	52	and	and	CC
cord-034687-57n88v6t	157	53	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	157	54	behavior	behavior	NN
cord-034687-57n88v6t	157	55	.	.	.
cord-034687-57n88v6t	158	1	30	30	CD
cord-034687-57n88v6t	158	2	,	,	,
cord-034687-57n88v6t	158	3	31	31	CD
cord-034687-57n88v6t	158	4	Restraint	restraint	NN
cord-034687-57n88v6t	158	5	stress	stress	NN
cord-034687-57n88v6t	158	6	or	or	CC
cord-034687-57n88v6t	158	7	corticosterone	corticosterone	NN
cord-034687-57n88v6t	158	8	treatments	treatment	NNS
cord-034687-57n88v6t	158	9	also	also	RB
cord-034687-57n88v6t	158	10	produce	produce	VBP
cord-034687-57n88v6t	158	11	a	a	DT
cord-034687-57n88v6t	158	12	delayed	delay	VBN
cord-034687-57n88v6t	158	13	increase	increase	NN
cord-034687-57n88v6t	158	14	in	in	IN
cord-034687-57n88v6t	158	15	2-AG	2-ag	CD
cord-034687-57n88v6t	158	16	levels	level	NNS
cord-034687-57n88v6t	158	17	in	in	IN
cord-034687-57n88v6t	158	18	the	the	DT
cord-034687-57n88v6t	158	19	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	158	20	,	,	,
cord-034687-57n88v6t	158	21	PFC	PFC	NNP
cord-034687-57n88v6t	158	22	,	,	,
cord-034687-57n88v6t	158	23	and	and	CC
cord-034687-57n88v6t	158	24	hippocampus	hippocampus	NN
cord-034687-57n88v6t	158	25	,	,	,
cord-034687-57n88v6t	158	26	associated	associate	VBN
cord-034687-57n88v6t	158	27	with	with	IN
cord-034687-57n88v6t	158	28	a	a	DT
cord-034687-57n88v6t	158	29	decreased	decreased	JJ
cord-034687-57n88v6t	158	30	HPA	HPA	NNP
cord-034687-57n88v6t	158	31	-	-	HYPH
cord-034687-57n88v6t	158	32	axis	axis	NN
cord-034687-57n88v6t	158	33	activity	activity	NN
cord-034687-57n88v6t	158	34	32	32	CD
cord-034687-57n88v6t	158	35	that	that	WDT
cord-034687-57n88v6t	158	36	modulates	modulate	VBZ
cord-034687-57n88v6t	158	37	memory	memory	NN
cord-034687-57n88v6t	158	38	processes	process	NNS
cord-034687-57n88v6t	158	39	and	and	CC
cord-034687-57n88v6t	158	40	pain	pain	NN
cord-034687-57n88v6t	158	41	perception	perception	NN
cord-034687-57n88v6t	158	42	after	after	IN
cord-034687-57n88v6t	158	43	stressful	stressful	JJ
cord-034687-57n88v6t	158	44	stimuli	stimulus	NNS
cord-034687-57n88v6t	158	45	.	.	.
cord-034687-57n88v6t	159	1	33	33	CD
cord-034687-57n88v6t	160	1	Therefore	therefore	RB
cord-034687-57n88v6t	160	2	,	,	,
cord-034687-57n88v6t	160	3	acute	acute	JJ
cord-034687-57n88v6t	160	4	stress	stress	NN
cord-034687-57n88v6t	160	5	exposure	exposure	NN
cord-034687-57n88v6t	160	6	has	have	VBZ
cord-034687-57n88v6t	160	7	emotional	emotional	JJ
cord-034687-57n88v6t	160	8	and	and	CC
cord-034687-57n88v6t	160	9	physiological	physiological	JJ
cord-034687-57n88v6t	160	10	consequences	consequence	NNS
cord-034687-57n88v6t	160	11	related	relate	VBN
cord-034687-57n88v6t	160	12	with	with	IN
cord-034687-57n88v6t	160	13	decreased	decrease	VBN
cord-034687-57n88v6t	160	14	anandamide	anandamide	NN
cord-034687-57n88v6t	160	15	production	production	NN
cord-034687-57n88v6t	160	16	,	,	,
cord-034687-57n88v6t	160	17	but	but	CC
cord-034687-57n88v6t	160	18	also	also	RB
cord-034687-57n88v6t	160	19	favors	favor	VBZ
cord-034687-57n88v6t	160	20	increased	increase	VBN
cord-034687-57n88v6t	160	21	2-AG	2-ag	CD
cord-034687-57n88v6t	160	22	levels	level	NNS
cord-034687-57n88v6t	160	23	that	that	WDT
cord-034687-57n88v6t	160	24	limit	limit	VBP
cord-034687-57n88v6t	160	25	the	the	DT
cord-034687-57n88v6t	160	26	stress	stress	NN
cord-034687-57n88v6t	160	27	response	response	NN
cord-034687-57n88v6t	160	28	and	and	CC
cord-034687-57n88v6t	160	29	have	have	VBP
cord-034687-57n88v6t	160	30	an	an	DT
cord-034687-57n88v6t	160	31	impact	impact	NN
cord-034687-57n88v6t	160	32	on	on	IN
cord-034687-57n88v6t	160	33	cognitive	cognitive	JJ
cord-034687-57n88v6t	160	34	performance	performance	NN
cord-034687-57n88v6t	160	35	.	.	.
cord-034687-57n88v6t	161	1	33	33	CD
cord-034687-57n88v6t	162	1	In	in	IN
cord-034687-57n88v6t	162	2	contrast	contrast	NN
cord-034687-57n88v6t	162	3	to	to	IN
cord-034687-57n88v6t	162	4	acute	acute	JJ
cord-034687-57n88v6t	162	5	stress	stress	NN
cord-034687-57n88v6t	162	6	,	,	,
cord-034687-57n88v6t	162	7	chronic	chronic	JJ
cord-034687-57n88v6t	162	8	stress	stress	NN
cord-034687-57n88v6t	162	9	predisposes	predispose	VBZ
cord-034687-57n88v6t	162	10	for	for	IN
cord-034687-57n88v6t	162	11	the	the	DT
cord-034687-57n88v6t	162	12	development	development	NN
cord-034687-57n88v6t	162	13	and	and	CC
cord-034687-57n88v6t	162	14	aggravation	aggravation	NN
cord-034687-57n88v6t	162	15	of	of	IN
cord-034687-57n88v6t	162	16	psychiatric	psychiatric	JJ
cord-034687-57n88v6t	162	17	disorders	disorder	NNS
cord-034687-57n88v6t	162	18	,	,	,
cord-034687-57n88v6t	162	19	including	include	VBG
cord-034687-57n88v6t	162	20	anxiety	anxiety	NN
cord-034687-57n88v6t	162	21	,	,	,
cord-034687-57n88v6t	162	22	depression	depression	NN
cord-034687-57n88v6t	162	23	,	,	,
cord-034687-57n88v6t	162	24	PTSD	PTSD	NNP
cord-034687-57n88v6t	162	25	,	,	,
cord-034687-57n88v6t	162	26	and	and	CC
cord-034687-57n88v6t	162	27	drug	drug	NN
cord-034687-57n88v6t	162	28	addiction	addiction	NN
cord-034687-57n88v6t	162	29	.	.	.
cord-034687-57n88v6t	163	1	34	34	CD
cord-034687-57n88v6t	163	2	Chronic	chronic	JJ
cord-034687-57n88v6t	163	3	stress	stress	NN
cord-034687-57n88v6t	163	4	induces	induce	VBZ
cord-034687-57n88v6t	163	5	prominent	prominent	JJ
cord-034687-57n88v6t	163	6	and	and	CC
cord-034687-57n88v6t	163	7	sustained	sustained	JJ
cord-034687-57n88v6t	163	8	changes	change	NNS
cord-034687-57n88v6t	163	9	in	in	IN
cord-034687-57n88v6t	163	10	the	the	DT
cord-034687-57n88v6t	163	11	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	163	12	system	system	NN
cord-034687-57n88v6t	163	13	,	,	,
cord-034687-57n88v6t	163	14	leading	lead	VBG
cord-034687-57n88v6t	163	15	to	to	IN
cord-034687-57n88v6t	163	16	decreases	decrease	NNS
cord-034687-57n88v6t	163	17	in	in	IN
cord-034687-57n88v6t	163	18	CB	CB	NNP
cord-034687-57n88v6t	163	19	1	1	CD
cord-034687-57n88v6t	163	20	R	r	NN
cord-034687-57n88v6t	163	21	signaling	signal	VBG
cord-034687-57n88v6t	163	22	in	in	IN
cord-034687-57n88v6t	163	23	brain	brain	NN
cord-034687-57n88v6t	163	24	regions	region	NNS
cord-034687-57n88v6t	163	25	related	relate	VBN
cord-034687-57n88v6t	163	26	with	with	IN
cord-034687-57n88v6t	163	27	emotional	emotional	JJ
cord-034687-57n88v6t	163	28	processing	processing	NN
cord-034687-57n88v6t	163	29	such	such	JJ
cord-034687-57n88v6t	163	30	as	as	IN
cord-034687-57n88v6t	163	31	the	the	DT
cord-034687-57n88v6t	163	32	hippocampus	hippocampus	NN
cord-034687-57n88v6t	163	33	,	,	,
cord-034687-57n88v6t	163	34	nucleus	nucleus	NN
cord-034687-57n88v6t	163	35	accumbens	accumbens	NNP
cord-034687-57n88v6t	163	36	,	,	,
cord-034687-57n88v6t	163	37	PFC	PFC	NNP
cord-034687-57n88v6t	163	38	,	,	,
cord-034687-57n88v6t	163	39	dorsal	dorsal	JJ
cord-034687-57n88v6t	163	40	raphe	raphe	NNP
cord-034687-57n88v6t	163	41	nucleus	nucleus	NN
cord-034687-57n88v6t	163	42	,	,	,
cord-034687-57n88v6t	163	43	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	163	44	,	,	,
cord-034687-57n88v6t	163	45	and	and	CC
cord-034687-57n88v6t	163	46	amygdala	amygdala	NN
cord-034687-57n88v6t	163	47	.	.	.
cord-034687-57n88v6t	164	1	5	5	LS
cord-034687-57n88v6t	165	1	Indeed	indeed	RB
cord-034687-57n88v6t	165	2	,	,	,
cord-034687-57n88v6t	165	3	sustained	sustain	VBD
cord-034687-57n88v6t	165	4	corticosterone	corticosterone	NN
cord-034687-57n88v6t	165	5	increments	increment	NNS
cord-034687-57n88v6t	165	6	after	after	IN
cord-034687-57n88v6t	165	7	repeated	repeat	VBN
cord-034687-57n88v6t	165	8	restraint	restraint	NN
cord-034687-57n88v6t	165	9	stress	stress	NN
cord-034687-57n88v6t	165	10	promote	promote	VBP
cord-034687-57n88v6t	165	11	FAAH	FAAH	NNP
cord-034687-57n88v6t	165	12	activity	activity	NN
cord-034687-57n88v6t	165	13	through	through	IN
cord-034687-57n88v6t	165	14	glucocorticoid	glucocorticoid	JJ
cord-034687-57n88v6t	165	15	stimulation	stimulation	NN
cord-034687-57n88v6t	165	16	.	.	.
cord-034687-57n88v6t	166	1	29	29	CD
cord-034687-57n88v6t	167	1	As	as	IN
cord-034687-57n88v6t	167	2	a	a	DT
cord-034687-57n88v6t	167	3	consequence	consequence	NN
cord-034687-57n88v6t	167	4	,	,	,
cord-034687-57n88v6t	167	5	anandamide	anandamide	NN
cord-034687-57n88v6t	167	6	levels	level	NNS
cord-034687-57n88v6t	167	7	are	be	VBP
cord-034687-57n88v6t	167	8	maintained	maintain	VBN
cord-034687-57n88v6t	167	9	low	low	JJ
cord-034687-57n88v6t	167	10	in	in	IN
cord-034687-57n88v6t	167	11	the	the	DT
cord-034687-57n88v6t	167	12	hippocampus	hippocampus	NN
cord-034687-57n88v6t	167	13	,	,	,
cord-034687-57n88v6t	167	14	hypothalamus	hypothalamus	NN
cord-034687-57n88v6t	167	15	,	,	,
cord-034687-57n88v6t	167	16	PFC	PFC	NNP
cord-034687-57n88v6t	167	17	,	,	,
cord-034687-57n88v6t	167	18	and	and	CC
cord-034687-57n88v6t	167	19	amygdala	amygdala	NN
cord-034687-57n88v6t	167	20	,	,	,
cord-034687-57n88v6t	167	21	35	35	CD
cord-034687-57n88v6t	167	22	which	which	WDT
cord-034687-57n88v6t	167	23	leads	lead	VBZ
cord-034687-57n88v6t	167	24	to	to	IN
cord-034687-57n88v6t	167	25	hyperexcitability	hyperexcitability	NN
cord-034687-57n88v6t	167	26	and	and	CC
cord-034687-57n88v6t	167	27	struc	struc	JJ
cord-034687-57n88v6t	167	28	-	-	HYPH
cord-034687-57n88v6t	167	29	tural	tural	JJ
cord-034687-57n88v6t	167	30	remodeling	remodeling	NN
cord-034687-57n88v6t	167	31	of	of	IN
cord-034687-57n88v6t	167	32	amygdalar	amygdalar	JJ
cord-034687-57n88v6t	167	33	circuits	circuit	NNS
cord-034687-57n88v6t	167	34	involved	involve	VBN
cord-034687-57n88v6t	167	35	in	in	IN
cord-034687-57n88v6t	167	36	anxiety	anxiety	NN
cord-034687-57n88v6t	167	37	.	.	.
cord-034687-57n88v6t	168	1	Indeed	indeed	RB
cord-034687-57n88v6t	168	2	,	,	,
cord-034687-57n88v6t	168	3	a	a	DT
cord-034687-57n88v6t	168	4	rat	rat	NN
cord-034687-57n88v6t	168	5	model	model	NN
cord-034687-57n88v6t	168	6	of	of	IN
cord-034687-57n88v6t	168	7	pathological	pathological	JJ
cord-034687-57n88v6t	168	8	anxiety	anxiety	NN
cord-034687-57n88v6t	168	9	reveals	reveal	VBZ
cord-034687-57n88v6t	168	10	constitutive	constitutive	JJ
cord-034687-57n88v6t	168	11	increases	increase	NNS
cord-034687-57n88v6t	168	12	in	in	IN
cord-034687-57n88v6t	168	13	corticotropin	corticotropin	NNP
cord-034687-57n88v6t	168	14	-	-	HYPH
cord-034687-57n88v6t	168	15	releasing	release	VBG
cord-034687-57n88v6t	168	16	factor	factor	NN
cord-034687-57n88v6t	168	17	(	(	-LRB-
cord-034687-57n88v6t	168	18	CRF	CRF	NNP
cord-034687-57n88v6t	168	19	)	)	-RRB-
cord-034687-57n88v6t	168	20	signaling	signal	VBG
cord-034687-57n88v6t	168	21	that	that	WDT
cord-034687-57n88v6t	168	22	lead	lead	NN
cord-034687-57n88v6t	168	23	to	to	IN
cord-034687-57n88v6t	168	24	sustained	sustained	JJ
cord-034687-57n88v6t	168	25	elevation	elevation	NN
cord-034687-57n88v6t	168	26	of	of	IN
cord-034687-57n88v6t	168	27	FAAH	FAAH	NNP
cord-034687-57n88v6t	168	28	activity	activity	NN
cord-034687-57n88v6t	168	29	and	and	CC
cord-034687-57n88v6t	168	30	dysregulation	dysregulation	NN
cord-034687-57n88v6t	168	31	of	of	IN
cord-034687-57n88v6t	168	32	inhibitory	inhibitory	JJ
cord-034687-57n88v6t	168	33	control	control	NN
cord-034687-57n88v6t	168	34	of	of	IN
cord-034687-57n88v6t	168	35	CeA	cea	JJ
cord-034687-57n88v6t	168	36	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	168	37	synapses	synapsis	NNS
cord-034687-57n88v6t	168	38	.	.	.
cord-034687-57n88v6t	169	1	36	36	CD
cord-034687-57n88v6t	169	2	Inhibition	inhibition	NN
cord-034687-57n88v6t	169	3	of	of	IN
cord-034687-57n88v6t	169	4	FAAH	FAAH	NNP
cord-034687-57n88v6t	169	5	hyperactivity	hyperactivity	NN
cord-034687-57n88v6t	169	6	prevents	prevent	VBZ
cord-034687-57n88v6t	169	7	these	these	DT
cord-034687-57n88v6t	169	8	effects	effect	NNS
cord-034687-57n88v6t	169	9	of	of	IN
cord-034687-57n88v6t	169	10	chronic	chronic	JJ
cord-034687-57n88v6t	169	11	stress	stress	NN
cord-034687-57n88v6t	169	12	37	37	CD
cord-034687-57n88v6t	169	13	and	and	CC
cord-034687-57n88v6t	169	14	protracted	protract	VBN
cord-034687-57n88v6t	169	15	structural	structural	JJ
cord-034687-57n88v6t	169	16	and	and	CC
cord-034687-57n88v6t	169	17	functional	functional	JJ
cord-034687-57n88v6t	169	18	changes	change	NNS
cord-034687-57n88v6t	169	19	that	that	WDT
cord-034687-57n88v6t	169	20	chronic	chronic	JJ
cord-034687-57n88v6t	169	21	stress	stress	NN
cord-034687-57n88v6t	169	22	promotes	promote	VBZ
cord-034687-57n88v6t	169	23	in	in	IN
cord-034687-57n88v6t	169	24	BLA	BLA	NNP
cord-034687-57n88v6t	169	25	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	169	26	neurons	neuron	NNS
cord-034687-57n88v6t	169	27	.	.	.
cord-034687-57n88v6t	170	1	38	38	CD
cord-034687-57n88v6t	170	2	,	,	,
cord-034687-57n88v6t	170	3	39	39	CD
cord-034687-57n88v6t	170	4	Interestingly	interestingly	RB
cord-034687-57n88v6t	170	5	,	,	,
cord-034687-57n88v6t	170	6	divergent	divergent	JJ
cord-034687-57n88v6t	170	7	results	result	NNS
cord-034687-57n88v6t	170	8	have	have	VBP
cord-034687-57n88v6t	170	9	been	be	VBN
cord-034687-57n88v6t	170	10	obtained	obtain	VBN
cord-034687-57n88v6t	170	11	after	after	IN
cord-034687-57n88v6t	170	12	exposure	exposure	NN
cord-034687-57n88v6t	170	13	to	to	IN
cord-034687-57n88v6t	170	14	other	other	JJ
cord-034687-57n88v6t	170	15	models	model	NNS
cord-034687-57n88v6t	170	16	of	of	IN
cord-034687-57n88v6t	170	17	chronic	chronic	JJ
cord-034687-57n88v6t	170	18	stress	stress	NN
cord-034687-57n88v6t	170	19	,	,	,
cord-034687-57n88v6t	170	20	40	40	CD
cord-034687-57n88v6t	170	21	suggesting	suggest	VBG
cord-034687-57n88v6t	170	22	that	that	IN
cord-034687-57n88v6t	170	23	the	the	DT
cord-034687-57n88v6t	170	24	nature	nature	NN
cord-034687-57n88v6t	170	25	of	of	IN
cord-034687-57n88v6t	170	26	the	the	DT
cord-034687-57n88v6t	170	27	stress	stress	NN
cord-034687-57n88v6t	170	28	or	or	CC
cord-034687-57n88v6t	170	29	the	the	DT
cord-034687-57n88v6t	170	30	existence	existence	NN
cord-034687-57n88v6t	170	31	of	of	IN
cord-034687-57n88v6t	170	32	previous	previous	JJ
cord-034687-57n88v6t	170	33	experiences	experience	NNS
cord-034687-57n88v6t	170	34	can	can	MD
cord-034687-57n88v6t	170	35	lead	lead	VB
cord-034687-57n88v6t	170	36	to	to	IN
cord-034687-57n88v6t	170	37	differentiated	differentiated	JJ
cord-034687-57n88v6t	170	38	stress	stress	NN
cord-034687-57n88v6t	170	39	-	-	HYPH
cord-034687-57n88v6t	170	40	induced	induce	VBN
cord-034687-57n88v6t	170	41	neuroadaptations	neuroadaptation	NNS
cord-034687-57n88v6t	170	42	.	.	.
cord-034687-57n88v6t	171	1	Indeed	indeed	RB
cord-034687-57n88v6t	171	2	,	,	,
cord-034687-57n88v6t	171	3	repeated	repeat	VBN
cord-034687-57n88v6t	171	4	exposure	exposure	NN
cord-034687-57n88v6t	171	5	to	to	IN
cord-034687-57n88v6t	171	6	the	the	DT
cord-034687-57n88v6t	171	7	same	same	JJ
cord-034687-57n88v6t	171	8	stress	stress	NN
cord-034687-57n88v6t	171	9	provokes	provoke	VBZ
cord-034687-57n88v6t	171	10	increased	increase	VBN
cord-034687-57n88v6t	171	11	2-AG	2-ag	CD
cord-034687-57n88v6t	171	12	concentrations	concentration	NNS
cord-034687-57n88v6t	171	13	that	that	WDT
cord-034687-57n88v6t	171	14	underlie	underlie	VBP
cord-034687-57n88v6t	171	15	habituation	habituation	NN
cord-034687-57n88v6t	171	16	to	to	TO
cord-034687-57n88v6t	171	17	stress	stress	NN
cord-034687-57n88v6t	171	18	in	in	IN
cord-034687-57n88v6t	171	19	adults	adult	NNS
cord-034687-57n88v6t	171	20	.	.	.
cord-034687-57n88v6t	172	1	41	41	CD
cord-034687-57n88v6t	172	2	Further	further	RB
cord-034687-57n88v6t	172	3	increasing	increase	VBG
cord-034687-57n88v6t	172	4	2-AG	2-ag	CD
cord-034687-57n88v6t	172	5	levels	level	NNS
cord-034687-57n88v6t	172	6	through	through	IN
cord-034687-57n88v6t	172	7	blockade	blockade	NN
cord-034687-57n88v6t	172	8	of	of	IN
cord-034687-57n88v6t	172	9	2-AG	2-ag	CD
cord-034687-57n88v6t	172	10	degradation	degradation	NN
cord-034687-57n88v6t	172	11	prevents	prevent	VBZ
cord-034687-57n88v6t	172	12	the	the	DT
cord-034687-57n88v6t	172	13	decrease	decrease	NN
cord-034687-57n88v6t	172	14	in	in	IN
cord-034687-57n88v6t	172	15	hippocampal	hippocampal	JJ
cord-034687-57n88v6t	172	16	neurogenesis	neurogenesis	NN
cord-034687-57n88v6t	172	17	and	and	CC
cord-034687-57n88v6t	172	18	long	long	JJ
cord-034687-57n88v6t	172	19	-	-	HYPH
cord-034687-57n88v6t	172	20	term	term	NN
cord-034687-57n88v6t	172	21	synaptic	synaptic	JJ
cord-034687-57n88v6t	172	22	effects	effect	NNS
cord-034687-57n88v6t	172	23	associated	associate	VBN
cord-034687-57n88v6t	172	24	with	with	IN
cord-034687-57n88v6t	172	25	chronic	chronic	JJ
cord-034687-57n88v6t	172	26	stress	stress	NN
cord-034687-57n88v6t	172	27	.	.	.
cord-034687-57n88v6t	173	1	42	42	CD
cord-034687-57n88v6t	173	2	Deletion	deletion	NN
cord-034687-57n88v6t	173	3	of	of	IN
cord-034687-57n88v6t	173	4	the	the	DT
cord-034687-57n88v6t	173	5	2-AG	2-ag	CD
cord-034687-57n88v6t	173	6	synthesizing	synthesize	VBG
cord-034687-57n88v6t	173	7	enzyme	enzyme	NN
cord-034687-57n88v6t	173	8	DAGLα	DAGLα	NNS
cord-034687-57n88v6t	173	9	in	in	IN
cord-034687-57n88v6t	173	10	PFC	PFC	NNP
cord-034687-57n88v6t	173	11	strengthens	strengthen	VBZ
cord-034687-57n88v6t	173	12	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	173	13	activity	activity	NN
cord-034687-57n88v6t	173	14	in	in	IN
cord-034687-57n88v6t	173	15	a	a	DT
cord-034687-57n88v6t	173	16	BLA	BLA	NNP
cord-034687-57n88v6t	173	17	-	-	HYPH
cord-034687-57n88v6t	173	18	PFC	PFC	NNP
cord-034687-57n88v6t	173	19	-	-	HYPH
cord-034687-57n88v6t	173	20	BLA	BLA	NNP
cord-034687-57n88v6t	173	21	circuit	circuit	NN
cord-034687-57n88v6t	173	22	that	that	WDT
cord-034687-57n88v6t	173	23	facilitates	facilitate	VBZ
cord-034687-57n88v6t	173	24	stress	stress	NN
cord-034687-57n88v6t	173	25	-	-	HYPH
cord-034687-57n88v6t	173	26	induced	induce	VBN
cord-034687-57n88v6t	173	27	anxiety	anxiety	NN
cord-034687-57n88v6t	173	28	-	-	HYPH
cord-034687-57n88v6t	173	29	like	like	JJ
cord-034687-57n88v6t	173	30	behavior	behavior	NN
cord-034687-57n88v6t	173	31	.	.	.
cord-034687-57n88v6t	174	1	43	43	CD
cord-034687-57n88v6t	175	1	These	these	DT
cord-034687-57n88v6t	175	2	data	datum	NNS
cord-034687-57n88v6t	175	3	show	show	VBP
cord-034687-57n88v6t	175	4	that	that	IN
cord-034687-57n88v6t	175	5	facilitating	facilitate	VBG
cord-034687-57n88v6t	175	6	synthesis	synthesis	NN
cord-034687-57n88v6t	175	7	or	or	CC
cord-034687-57n88v6t	175	8	inhibiting	inhibit	VBG
cord-034687-57n88v6t	175	9	degradation	degradation	NN
cord-034687-57n88v6t	175	10	of	of	IN
cord-034687-57n88v6t	175	11	anandamide	anandamide	NN
cord-034687-57n88v6t	175	12	and	and	CC
cord-034687-57n88v6t	175	13	2-AG	2-ag	CD
cord-034687-57n88v6t	175	14	have	have	VBP
cord-034687-57n88v6t	175	15	overlapping	overlap	VBG
cord-034687-57n88v6t	175	16	consequences	consequence	NNS
cord-034687-57n88v6t	175	17	,	,	,
cord-034687-57n88v6t	175	18	suggesting	suggest	VBG
cord-034687-57n88v6t	175	19	the	the	DT
cord-034687-57n88v6t	175	20	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	175	21	potential	potential	NN
cord-034687-57n88v6t	175	22	of	of	IN
cord-034687-57n88v6t	175	23	these	these	DT
cord-034687-57n88v6t	175	24	enzyme	enzyme	NN
cord-034687-57n88v6t	175	25	modulators	modulator	NNS
cord-034687-57n88v6t	175	26	for	for	IN
cord-034687-57n88v6t	175	27	the	the	DT
cord-034687-57n88v6t	175	28	treatment	treatment	NN
cord-034687-57n88v6t	175	29	of	of	IN
cord-034687-57n88v6t	175	30	stress	stress	NN
cord-034687-57n88v6t	175	31	-	-	HYPH
cord-034687-57n88v6t	175	32	related	relate	VBN
cord-034687-57n88v6t	175	33	disorders	disorder	NNS
cord-034687-57n88v6t	175	34	.	.	.
cord-034687-57n88v6t	176	1	The	the	DT
cord-034687-57n88v6t	176	2	redundancy	redundancy	NN
cord-034687-57n88v6t	176	3	exhibited	exhibit	VBN
cord-034687-57n88v6t	176	4	by	by	IN
cord-034687-57n88v6t	176	5	2-AG	2-ag	CD
cord-034687-57n88v6t	176	6	and	and	CC
cord-034687-57n88v6t	176	7	anandamide	anandamide	NN
cord-034687-57n88v6t	176	8	could	could	MD
cord-034687-57n88v6t	176	9	potentially	potentially	RB
cord-034687-57n88v6t	176	10	be	be	VB
cord-034687-57n88v6t	176	11	exploited	exploit	VBN
cord-034687-57n88v6t	176	12	to	to	TO
cord-034687-57n88v6t	176	13	design	design	VB
cord-034687-57n88v6t	176	14	drug	drug	NN
cord-034687-57n88v6t	176	15	combinations	combination	NNS
cord-034687-57n88v6t	176	16	with	with	IN
cord-034687-57n88v6t	176	17	lower	low	JJR
cord-034687-57n88v6t	176	18	doses	dose	NNS
cord-034687-57n88v6t	176	19	of	of	IN
cord-034687-57n88v6t	176	20	active	active	JJ
cord-034687-57n88v6t	176	21	ingredients	ingredient	NNS
cord-034687-57n88v6t	176	22	and	and	CC
cord-034687-57n88v6t	176	23	may	may	MD
cord-034687-57n88v6t	176	24	be	be	VB
cord-034687-57n88v6t	176	25	useful	useful	JJ
cord-034687-57n88v6t	176	26	to	to	TO
cord-034687-57n88v6t	176	27	tackle	tackle	VB
cord-034687-57n88v6t	176	28	different	different	JJ
cord-034687-57n88v6t	176	29	aspects	aspect	NNS
cord-034687-57n88v6t	176	30	of	of	IN
cord-034687-57n88v6t	176	31	chronic	chronic	JJ
cord-034687-57n88v6t	176	32	stress	stress	NN
cord-034687-57n88v6t	176	33	disorders	disorder	NNS
cord-034687-57n88v6t	176	34	at	at	IN
cord-034687-57n88v6t	176	35	once	once	RB
cord-034687-57n88v6t	176	36	.	.	.
cord-034687-57n88v6t	177	1	Contemporary	contemporary	JJ
cord-034687-57n88v6t	177	2	society	society	NN
cord-034687-57n88v6t	177	3	is	be	VBZ
cord-034687-57n88v6t	177	4	exposed	expose	VBN
cord-034687-57n88v6t	177	5	to	to	IN
cord-034687-57n88v6t	177	6	a	a	DT
cord-034687-57n88v6t	177	7	multiplicity	multiplicity	NN
cord-034687-57n88v6t	177	8	of	of	IN
cord-034687-57n88v6t	177	9	external	external	JJ
cord-034687-57n88v6t	177	10	factors	factor	NNS
cord-034687-57n88v6t	177	11	that	that	WDT
cord-034687-57n88v6t	177	12	constitute	constitute	VBP
cord-034687-57n88v6t	177	13	sources	source	NNS
cord-034687-57n88v6t	177	14	of	of	IN
cord-034687-57n88v6t	177	15	anxiety	anxiety	NN
cord-034687-57n88v6t	177	16	,	,	,
cord-034687-57n88v6t	177	17	including	include	VBG
cord-034687-57n88v6t	177	18	excessive	excessive	JJ
cord-034687-57n88v6t	177	19	workloads	workload	NNS
cord-034687-57n88v6t	177	20	,	,	,
cord-034687-57n88v6t	177	21	difficult	difficult	JJ
cord-034687-57n88v6t	177	22	personal	personal	JJ
cord-034687-57n88v6t	177	23	relationships	relationship	NNS
cord-034687-57n88v6t	177	24	,	,	,
cord-034687-57n88v6t	177	25	sexual	sexual	JJ
cord-034687-57n88v6t	177	26	abuse	abuse	NN
cord-034687-57n88v6t	177	27	,	,	,
cord-034687-57n88v6t	177	28	drug	drug	NN
cord-034687-57n88v6t	177	29	consumption	consumption	NN
cord-034687-57n88v6t	177	30	,	,	,
cord-034687-57n88v6t	177	31	digital	digital	JJ
cord-034687-57n88v6t	177	32	social	social	JJ
cord-034687-57n88v6t	177	33	media	medium	NNS
cord-034687-57n88v6t	177	34	,	,	,
cord-034687-57n88v6t	177	35	or	or	CC
cord-034687-57n88v6t	177	36	even	even	RB
cord-034687-57n88v6t	177	37	current	current	JJ
cord-034687-57n88v6t	177	38	infectious	infectious	JJ
cord-034687-57n88v6t	177	39	disease	disease	NN
cord-034687-57n88v6t	177	40	pandemics	pandemic	NNS
cord-034687-57n88v6t	177	41	.	.	.
cord-034687-57n88v6t	178	1	44	44	CD
cord-034687-57n88v6t	178	2	Anxiety	anxiety	NN
cord-034687-57n88v6t	178	3	can	can	MD
cord-034687-57n88v6t	178	4	be	be	VB
cord-034687-57n88v6t	178	5	defined	define	VBN
cord-034687-57n88v6t	178	6	as	as	IN
cord-034687-57n88v6t	178	7	a	a	DT
cord-034687-57n88v6t	178	8	mental	mental	JJ
cord-034687-57n88v6t	178	9	state	state	NN
cord-034687-57n88v6t	178	10	of	of	IN
cord-034687-57n88v6t	178	11	discomfort	discomfort	NN
cord-034687-57n88v6t	178	12	triggered	trigger	VBN
cord-034687-57n88v6t	178	13	by	by	IN
cord-034687-57n88v6t	178	14	uncertain	uncertain	JJ
cord-034687-57n88v6t	178	15	threats	threat	NNS
cord-034687-57n88v6t	178	16	.	.	.
cord-034687-57n88v6t	179	1	45	45	CD
cord-034687-57n88v6t	180	1	These	these	DT
cord-034687-57n88v6t	180	2	threats	threat	NNS
cord-034687-57n88v6t	180	3	are	be	VBP
cord-034687-57n88v6t	180	4	estimated	estimate	VBN
cord-034687-57n88v6t	180	5	to	to	TO
cord-034687-57n88v6t	180	6	be	be	VB
cord-034687-57n88v6t	180	7	distant	distant	JJ
cord-034687-57n88v6t	180	8	in	in	IN
cord-034687-57n88v6t	180	9	time	time	NN
cord-034687-57n88v6t	180	10	or	or	CC
cord-034687-57n88v6t	180	11	space	space	NN
cord-034687-57n88v6t	180	12	and	and	CC
cord-034687-57n88v6t	180	13	lead	lead	VB
cord-034687-57n88v6t	180	14	to	to	IN
cord-034687-57n88v6t	180	15	anticipatory	anticipatory	JJ
cord-034687-57n88v6t	180	16	affective	affective	JJ
cord-034687-57n88v6t	180	17	,	,	,
cord-034687-57n88v6t	180	18	cognitive	cognitive	JJ
cord-034687-57n88v6t	180	19	,	,	,
cord-034687-57n88v6t	180	20	behavioral	behavioral	JJ
cord-034687-57n88v6t	180	21	,	,	,
cord-034687-57n88v6t	180	22	and	and	CC
cord-034687-57n88v6t	180	23	physiological	physiological	JJ
cord-034687-57n88v6t	180	24	changes	change	NNS
cord-034687-57n88v6t	180	25	and	and	CC
cord-034687-57n88v6t	180	26	a	a	DT
cord-034687-57n88v6t	180	27	continuous	continuous	JJ
cord-034687-57n88v6t	180	28	risk	risk	NN
cord-034687-57n88v6t	180	29	assessment	assessment	NN
cord-034687-57n88v6t	180	30	that	that	WDT
cord-034687-57n88v6t	180	31	can	can	MD
cord-034687-57n88v6t	180	32	persist	persist	VB
cord-034687-57n88v6t	180	33	until	until	IN
cord-034687-57n88v6t	180	34	the	the	DT
cord-034687-57n88v6t	180	35	uncertainty	uncertainty	NN
cord-034687-57n88v6t	180	36	is	be	VBZ
cord-034687-57n88v6t	180	37	resolved	resolve	VBN
cord-034687-57n88v6t	180	38	.	.	.
cord-034687-57n88v6t	181	1	46	46	CD
cord-034687-57n88v6t	181	2	Internal	internal	JJ
cord-034687-57n88v6t	181	3	changes	change	NNS
cord-034687-57n88v6t	181	4	are	be	VBP
cord-034687-57n88v6t	181	5	adaptive	adaptive	JJ
cord-034687-57n88v6t	181	6	and	and	CC
cord-034687-57n88v6t	181	7	favor	favor	VBP
cord-034687-57n88v6t	181	8	behaviors	behavior	NNS
cord-034687-57n88v6t	181	9	that	that	WDT
cord-034687-57n88v6t	181	10	protect	protect	VBP
cord-034687-57n88v6t	181	11	the	the	DT
cord-034687-57n88v6t	181	12	organism	organism	NN
cord-034687-57n88v6t	181	13	from	from	IN
cord-034687-57n88v6t	181	14	dangerous	dangerous	JJ
cord-034687-57n88v6t	181	15	situations	situation	NNS
cord-034687-57n88v6t	181	16	,	,	,
cord-034687-57n88v6t	181	17	although	although	IN
cord-034687-57n88v6t	181	18	in	in	IN
cord-034687-57n88v6t	181	19	certain	certain	JJ
cord-034687-57n88v6t	181	20	conditions	condition	NNS
cord-034687-57n88v6t	181	21	become	become	VBP
cord-034687-57n88v6t	181	22	disproportional	disproportional	JJ
cord-034687-57n88v6t	181	23	and	and	CC
cord-034687-57n88v6t	181	24	result	result	VB
cord-034687-57n88v6t	181	25	in	in	IN
cord-034687-57n88v6t	181	26	anxiety	anxiety	NN
cord-034687-57n88v6t	181	27	-	-	HYPH
cord-034687-57n88v6t	181	28	related	relate	VBN
cord-034687-57n88v6t	181	29	disorders	disorder	NNS
cord-034687-57n88v6t	181	30	.	.	.
cord-034687-57n88v6t	182	1	One	one	CD
cord-034687-57n88v6t	182	2	of	of	IN
cord-034687-57n88v6t	182	3	the	the	DT
cord-034687-57n88v6t	182	4	main	main	JJ
cord-034687-57n88v6t	182	5	medical	medical	JJ
cord-034687-57n88v6t	182	6	reasons	reason	NNS
cord-034687-57n88v6t	182	7	for	for	IN
cord-034687-57n88v6t	182	8	cannabis	cannabis	NN
cord-034687-57n88v6t	182	9	consumption	consumption	NN
cord-034687-57n88v6t	182	10	is	be	VBZ
cord-034687-57n88v6t	182	11	anxiety	anxiety	NN
cord-034687-57n88v6t	182	12	relief	relief	NN
cord-034687-57n88v6t	182	13	,	,	,
cord-034687-57n88v6t	182	14	47	47	CD
cord-034687-57n88v6t	182	15	although	although	IN
cord-034687-57n88v6t	182	16	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	182	17	responses	response	NNS
cord-034687-57n88v6t	182	18	are	be	VBP
cord-034687-57n88v6t	182	19	also	also	RB
cord-034687-57n88v6t	182	20	frequently	frequently	RB
cord-034687-57n88v6t	182	21	reported	report	VBN
cord-034687-57n88v6t	182	22	after	after	IN
cord-034687-57n88v6t	182	23	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	182	24	consumption	consumption	NN
cord-034687-57n88v6t	182	25	.	.	.
cord-034687-57n88v6t	183	1	48	48	CD
cord-034687-57n88v6t	184	1	Indeed	indeed	RB
cord-034687-57n88v6t	184	2	,	,	,
cord-034687-57n88v6t	184	3	high	high	JJ
cord-034687-57n88v6t	184	4	doses	dose	NNS
cord-034687-57n88v6t	184	5	or	or	CC
cord-034687-57n88v6t	184	6	long	long	JJ
cord-034687-57n88v6t	184	7	-	-	HYPH
cord-034687-57n88v6t	184	8	term	term	NN
cord-034687-57n88v6t	184	9	treatments	treatment	NNS
cord-034687-57n88v6t	184	10	with	with	IN
cord-034687-57n88v6t	184	11	THC	thc	NN
cord-034687-57n88v6t	184	12	induce	induce	NN
cord-034687-57n88v6t	184	13	anxiety	anxiety	NN
cord-034687-57n88v6t	184	14	in	in	IN
cord-034687-57n88v6t	184	15	humans	human	NNS
cord-034687-57n88v6t	184	16	and	and	CC
cord-034687-57n88v6t	184	17	rodents	rodent	NNS
cord-034687-57n88v6t	184	18	.	.	.
cord-034687-57n88v6t	185	1	On	on	IN
cord-034687-57n88v6t	185	2	the	the	DT
cord-034687-57n88v6t	185	3	other	other	JJ
cord-034687-57n88v6t	185	4	hand	hand	NN
cord-034687-57n88v6t	185	5	,	,	,
cord-034687-57n88v6t	185	6	acute	acute	JJ
cord-034687-57n88v6t	185	7	administration	administration	NN
cord-034687-57n88v6t	185	8	of	of	IN
cord-034687-57n88v6t	185	9	the	the	DT
cord-034687-57n88v6t	185	10	non	non	JJ
cord-034687-57n88v6t	185	11	-	-	JJ
cord-034687-57n88v6t	185	12	psychotropic	psychotropic	JJ
cord-034687-57n88v6t	185	13	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	185	14	cannabidiol	cannabidiol	FW
cord-034687-57n88v6t	185	15	(	(	-LRB-
cord-034687-57n88v6t	185	16	CBD	CBD	NNP
cord-034687-57n88v6t	185	17	)	)	-RRB-
cord-034687-57n88v6t	185	18	or	or	CC
cord-034687-57n88v6t	185	19	low	low	JJ
cord-034687-57n88v6t	185	20	THC	thc	NN
cord-034687-57n88v6t	185	21	doses	dose	NNS
cord-034687-57n88v6t	185	22	can	can	MD
cord-034687-57n88v6t	185	23	relieve	relieve	VB
cord-034687-57n88v6t	185	24	anxiety	anxiety	NN
cord-034687-57n88v6t	185	25	-	-	HYPH
cord-034687-57n88v6t	185	26	related	relate	VBN
cord-034687-57n88v6t	185	27	behavior	behavior	NN
cord-034687-57n88v6t	185	28	.	.	.
cord-034687-57n88v6t	186	1	47	47	CD
cord-034687-57n88v6t	187	1	The	the	DT
cord-034687-57n88v6t	187	2	Cre	Cre	NNP
cord-034687-57n88v6t	187	3	-	-	HYPH
cord-034687-57n88v6t	187	4	Lox	Lox	NNP
cord-034687-57n88v6t	187	5	technology	technology	NN
cord-034687-57n88v6t	187	6	allowed	allow	VBD
cord-034687-57n88v6t	187	7	the	the	DT
cord-034687-57n88v6t	187	8	dissection	dissection	NN
cord-034687-57n88v6t	187	9	of	of	IN
cord-034687-57n88v6t	187	10	biological	biological	JJ
cord-034687-57n88v6t	187	11	substrates	substrate	NNS
cord-034687-57n88v6t	187	12	underlying	underlie	VBG
cord-034687-57n88v6t	187	13	this	this	DT
cord-034687-57n88v6t	187	14	dual	dual	JJ
cord-034687-57n88v6t	187	15	effect	effect	NN
cord-034687-57n88v6t	187	16	of	of	IN
cord-034687-57n88v6t	187	17	CB	CB	NNP
cord-034687-57n88v6t	187	18	1	1	CD
cord-034687-57n88v6t	187	19	R	r	NN
cord-034687-57n88v6t	187	20	activation	activation	NN
cord-034687-57n88v6t	187	21	.	.	.
cord-034687-57n88v6t	188	1	Glutamatergic	Glutamatergic	NNP
cord-034687-57n88v6t	188	2	and	and	CC
cord-034687-57n88v6t	188	3	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	188	4	neurons	neuron	NNS
cord-034687-57n88v6t	188	5	expressing	express	VBG
cord-034687-57n88v6t	188	6	CB	CB	NNP
cord-034687-57n88v6t	188	7	1	1	CD
cord-034687-57n88v6t	188	8	R	r	NN
cord-034687-57n88v6t	188	9	are	be	VBP
cord-034687-57n88v6t	188	10	widely	widely	RB
cord-034687-57n88v6t	188	11	distributed	distribute	VBN
cord-034687-57n88v6t	188	12	in	in	IN
cord-034687-57n88v6t	188	13	key	key	JJ
cord-034687-57n88v6t	188	14	brain	brain	NN
cord-034687-57n88v6t	188	15	areas	area	NNS
cord-034687-57n88v6t	188	16	involved	involve	VBN
cord-034687-57n88v6t	188	17	in	in	IN
cord-034687-57n88v6t	188	18	anxiety	anxiety	NN
cord-034687-57n88v6t	188	19	,	,	,
cord-034687-57n88v6t	188	20	such	such	JJ
cord-034687-57n88v6t	188	21	as	as	IN
cord-034687-57n88v6t	188	22	the	the	DT
cord-034687-57n88v6t	188	23	amygdala	amygdala	NN
cord-034687-57n88v6t	188	24	,	,	,
cord-034687-57n88v6t	188	25	hippocampus	hippocampus	NN
cord-034687-57n88v6t	188	26	,	,	,
cord-034687-57n88v6t	188	27	or	or	CC
cord-034687-57n88v6t	188	28	PFC	PFC	NNP
cord-034687-57n88v6t	188	29	.	.	.
cord-034687-57n88v6t	189	1	Presynaptic	Presynaptic	NNP
cord-034687-57n88v6t	189	2	CB	CB	NNP
cord-034687-57n88v6t	189	3	1	1	CD
cord-034687-57n88v6t	189	4	R	r	NN
cord-034687-57n88v6t	189	5	of	of	IN
cord-034687-57n88v6t	189	6	cortical	cortical	JJ
cord-034687-57n88v6t	189	7	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	189	8	neurons	neuron	NNS
cord-034687-57n88v6t	189	9	inhibit	inhibit	VBP
cord-034687-57n88v6t	189	10	glutamate	glutamate	NN
cord-034687-57n88v6t	189	11	release	release	NN
cord-034687-57n88v6t	189	12	,	,	,
cord-034687-57n88v6t	189	13	and	and	CC
cord-034687-57n88v6t	189	14	their	-PRON-	PRP$
cord-034687-57n88v6t	189	15	activation	activation	NN
cord-034687-57n88v6t	189	16	induces	induce	VBZ
cord-034687-57n88v6t	189	17	anxiolysis	anxiolysis	NN
cord-034687-57n88v6t	189	18	.	.	.
cord-034687-57n88v6t	190	1	49	49	CD
cord-034687-57n88v6t	191	1	In	in	IN
cord-034687-57n88v6t	191	2	agreement	agreement	NN
cord-034687-57n88v6t	191	3	,	,	,
cord-034687-57n88v6t	191	4	anxiety	anxiety	NN
cord-034687-57n88v6t	191	5	-	-	HYPH
cord-034687-57n88v6t	191	6	like	like	JJ
cord-034687-57n88v6t	191	7	behavior	behavior	NN
cord-034687-57n88v6t	191	8	is	be	VBZ
cord-034687-57n88v6t	191	9	observed	observe	VBN
cord-034687-57n88v6t	191	10	in	in	IN
cord-034687-57n88v6t	191	11	mice	mouse	NNS
cord-034687-57n88v6t	191	12	lacking	lack	VBG
cord-034687-57n88v6t	191	13	CB	CB	NNP
cord-034687-57n88v6t	191	14	1	1	CD
cord-034687-57n88v6t	191	15	R	r	NN
cord-034687-57n88v6t	191	16	in	in	IN
cord-034687-57n88v6t	191	17	cortical	cortical	JJ
cord-034687-57n88v6t	191	18	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	191	19	neurons	neuron	NNS
cord-034687-57n88v6t	191	20	,	,	,
cord-034687-57n88v6t	191	21	8	8	CD
cord-034687-57n88v6t	191	22	,	,	,
cord-034687-57n88v6t	191	23	50	50	CD
cord-034687-57n88v6t	191	24	and	and	CC
cord-034687-57n88v6t	191	25	reinstatement	reinstatement	NN
cord-034687-57n88v6t	191	26	of	of	IN
cord-034687-57n88v6t	191	27	CB	CB	NNP
cord-034687-57n88v6t	191	28	1	1	CD
cord-034687-57n88v6t	191	29	R	r	NN
cord-034687-57n88v6t	191	30	expression	expression	NN
cord-034687-57n88v6t	191	31	in	in	IN
cord-034687-57n88v6t	191	32	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	191	33	neurons	neuron	NNS
cord-034687-57n88v6t	191	34	of	of	IN
cord-034687-57n88v6t	191	35	CB	CB	NNP
cord-034687-57n88v6t	191	36	1	1	CD
cord-034687-57n88v6t	191	37	R	r	NN
cord-034687-57n88v6t	191	38	-	-	HYPH
cord-034687-57n88v6t	191	39	knockout	knockout	NN
cord-034687-57n88v6t	191	40	mice	mouse	NNS
cord-034687-57n88v6t	191	41	partly	partly	RB
cord-034687-57n88v6t	191	42	restores	restore	VBZ
cord-034687-57n88v6t	191	43	normal	normal	JJ
cord-034687-57n88v6t	191	44	anxiety	anxiety	NN
cord-034687-57n88v6t	191	45	levels	level	NNS
cord-034687-57n88v6t	191	46	.	.	.
cord-034687-57n88v6t	192	1	51	51	CD
cord-034687-57n88v6t	193	1	In	in	IN
cord-034687-57n88v6t	193	2	contrast	contrast	NN
cord-034687-57n88v6t	193	3	,	,	,
cord-034687-57n88v6t	193	4	CB	CB	NNP
cord-034687-57n88v6t	193	5	1	1	CD
cord-034687-57n88v6t	193	6	R	r	NN
cord-034687-57n88v6t	193	7	activation	activation	NN
cord-034687-57n88v6t	193	8	from	from	IN
cord-034687-57n88v6t	193	9	the	the	DT
cord-034687-57n88v6t	193	10	larger	large	JJR
cord-034687-57n88v6t	193	11	population	population	NN
cord-034687-57n88v6t	193	12	of	of	IN
cord-034687-57n88v6t	193	13	forebrain	forebrain	JJ
cord-034687-57n88v6t	193	14	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	193	15	neurons	neuron	NNS
cord-034687-57n88v6t	193	16	restricts	restrict	VBZ
cord-034687-57n88v6t	193	17	the	the	DT
cord-034687-57n88v6t	193	18	inhibitory	inhibitory	JJ
cord-034687-57n88v6t	193	19	GABA	GABA	NNP
cord-034687-57n88v6t	193	20	tone	tone	NN
cord-034687-57n88v6t	193	21	and	and	CC
cord-034687-57n88v6t	193	22	facilitates	facilitate	VBZ
cord-034687-57n88v6t	193	23	anxiety	anxiety	NN
cord-034687-57n88v6t	193	24	-	-	HYPH
cord-034687-57n88v6t	193	25	like	like	JJ
cord-034687-57n88v6t	193	26	behavior	behavior	NN
cord-034687-57n88v6t	193	27	in	in	IN
cord-034687-57n88v6t	193	28	basal	basal	NN
cord-034687-57n88v6t	193	29	conditions	condition	NNS
cord-034687-57n88v6t	193	30	.	.	.
cord-034687-57n88v6t	194	1	49	49	CD
cord-034687-57n88v6t	195	1	This	this	DT
cord-034687-57n88v6t	195	2	function	function	NN
cord-034687-57n88v6t	195	3	is	be	VBZ
cord-034687-57n88v6t	195	4	abrogated	abrogate	VBN
cord-034687-57n88v6t	195	5	in	in	IN
cord-034687-57n88v6t	195	6	mice	mouse	NNS
cord-034687-57n88v6t	195	7	lacking	lack	VBG
cord-034687-57n88v6t	195	8	CB	CB	NNP
cord-034687-57n88v6t	195	9	1	1	CD
cord-034687-57n88v6t	195	10	R	r	NN
cord-034687-57n88v6t	195	11	in	in	IN
cord-034687-57n88v6t	195	12	forebrain	forebrain	NN
cord-034687-57n88v6t	195	13	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	195	14	neurons	neuron	NNS
cord-034687-57n88v6t	195	15	.	.	.
cord-034687-57n88v6t	196	1	50	50	CD
cord-034687-57n88v6t	196	2	,	,	,
cord-034687-57n88v6t	196	3	52	52	CD
cord-034687-57n88v6t	196	4	,	,	,
cord-034687-57n88v6t	196	5	53	53	CD
cord-034687-57n88v6t	197	1	Interestingly	interestingly	RB
cord-034687-57n88v6t	197	2	,	,	,
cord-034687-57n88v6t	197	3	the	the	DT
cord-034687-57n88v6t	197	4	presence	presence	NN
cord-034687-57n88v6t	197	5	of	of	IN
cord-034687-57n88v6t	197	6	CB	CB	NNP
cord-034687-57n88v6t	197	7	1	1	CD
cord-034687-57n88v6t	197	8	R	r	NN
cord-034687-57n88v6t	197	9	in	in	IN
cord-034687-57n88v6t	197	10	forebrain	forebrain	JJ
cord-034687-57n88v6t	197	11	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	197	12	neurons	neuron	NNS
cord-034687-57n88v6t	197	13	was	be	VBD
cord-034687-57n88v6t	197	14	also	also	RB
cord-034687-57n88v6t	197	15	essential	essential	JJ
cord-034687-57n88v6t	197	16	for	for	IN
cord-034687-57n88v6t	197	17	the	the	DT
cord-034687-57n88v6t	197	18	serenity	serenity	NN
cord-034687-57n88v6t	197	19	obtained	obtain	VBN
cord-034687-57n88v6t	197	20	after	after	IN
cord-034687-57n88v6t	197	21	physical	physical	JJ
cord-034687-57n88v6t	197	22	exercising	exercising	NN
cord-034687-57n88v6t	197	23	,	,	,
cord-034687-57n88v6t	197	24	interpreted	interpret	VBN
cord-034687-57n88v6t	197	25	as	as	IN
cord-034687-57n88v6t	197	26	the	the	DT
cord-034687-57n88v6t	197	27	opposite	opposite	NN
cord-034687-57n88v6t	197	28	of	of	IN
cord-034687-57n88v6t	197	29	anxiety	anxiety	NN
cord-034687-57n88v6t	197	30	-	-	HYPH
cord-034687-57n88v6t	197	31	like	like	JJ
cord-034687-57n88v6t	197	32	behavior	behavior	NN
cord-034687-57n88v6t	197	33	.	.	.
cord-034687-57n88v6t	198	1	54	54	CD
cord-034687-57n88v6t	199	1	Thus	thus	RB
cord-034687-57n88v6t	199	2	,	,	,
cord-034687-57n88v6t	199	3	although	although	IN
cord-034687-57n88v6t	199	4	stimulation	stimulation	NN
cord-034687-57n88v6t	199	5	of	of	IN
cord-034687-57n88v6t	199	6	CB	CB	NNP
cord-034687-57n88v6t	199	7	1	1	CD
cord-034687-57n88v6t	199	8	R	r	NN
cord-034687-57n88v6t	199	9	of	of	IN
cord-034687-57n88v6t	199	10	forebrain	forebrain	NN
cord-034687-57n88v6t	199	11	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	199	12	neurons	neuron	NNS
cord-034687-57n88v6t	199	13	is	be	VBZ
cord-034687-57n88v6t	199	14	related	relate	VBN
cord-034687-57n88v6t	199	15	with	with	IN
cord-034687-57n88v6t	199	16	the	the	DT
cord-034687-57n88v6t	199	17	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	199	18	effects	effect	NNS
cord-034687-57n88v6t	199	19	of	of	IN
cord-034687-57n88v6t	199	20	high	high	JJ
cord-034687-57n88v6t	199	21	THC	thc	NN
cord-034687-57n88v6t	199	22	doses	dose	NNS
cord-034687-57n88v6t	199	23	,	,	,
cord-034687-57n88v6t	199	24	the	the	DT
cord-034687-57n88v6t	199	25	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	199	26	tone	tone	NN
cord-034687-57n88v6t	199	27	of	of	IN
cord-034687-57n88v6t	199	28	this	this	DT
cord-034687-57n88v6t	199	29	GABAergic	gabaergic	JJ
cord-034687-57n88v6t	199	30	neuronal	neuronal	JJ
cord-034687-57n88v6t	199	31	population	population	NN
cord-034687-57n88v6t	199	32	can	can	MD
cord-034687-57n88v6t	199	33	have	have	VB
cord-034687-57n88v6t	199	34	bidirectional	bidirectional	JJ
cord-034687-57n88v6t	199	35	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	199	36	or	or	CC
cord-034687-57n88v6t	199	37	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	199	38	effects	effect	NNS
cord-034687-57n88v6t	199	39	depending	depend	VBG
cord-034687-57n88v6t	199	40	on	on	IN
cord-034687-57n88v6t	199	41	the	the	DT
cord-034687-57n88v6t	199	42	basal	basal	NN
cord-034687-57n88v6t	199	43	status	status	NN
cord-034687-57n88v6t	199	44	of	of	IN
cord-034687-57n88v6t	199	45	the	the	DT
cord-034687-57n88v6t	199	46	individuals	individual	NNS
cord-034687-57n88v6t	199	47	.	.	.
cord-034687-57n88v6t	200	1	54	54	CD
cord-034687-57n88v6t	201	1	This	this	DT
cord-034687-57n88v6t	201	2	complex	complex	JJ
cord-034687-57n88v6t	201	3	modulatory	modulatory	JJ
cord-034687-57n88v6t	201	4	function	function	NN
cord-034687-57n88v6t	201	5	of	of	IN
cord-034687-57n88v6t	201	6	the	the	DT
cord-034687-57n88v6t	201	7	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	201	8	system	system	NN
cord-034687-57n88v6t	201	9	on	on	IN
cord-034687-57n88v6t	201	10	anxiety	anxiety	NN
cord-034687-57n88v6t	201	11	needs	need	VBZ
cord-034687-57n88v6t	201	12	to	to	TO
cord-034687-57n88v6t	201	13	be	be	VB
cord-034687-57n88v6t	201	14	carefully	carefully	RB
cord-034687-57n88v6t	201	15	understood	understand	VBN
cord-034687-57n88v6t	201	16	to	to	TO
cord-034687-57n88v6t	201	17	allow	allow	VB
cord-034687-57n88v6t	201	18	efficient	efficient	JJ
cord-034687-57n88v6t	201	19	modulation	modulation	NN
cord-034687-57n88v6t	201	20	in	in	IN
cord-034687-57n88v6t	201	21	the	the	DT
cord-034687-57n88v6t	201	22	clinics	clinic	NNS
cord-034687-57n88v6t	201	23	.	.	.
cord-034687-57n88v6t	202	1	Recent	recent	JJ
cord-034687-57n88v6t	202	2	advances	advance	NNS
cord-034687-57n88v6t	202	3	have	have	VBP
cord-034687-57n88v6t	202	4	started	start	VBN
cord-034687-57n88v6t	202	5	to	to	TO
cord-034687-57n88v6t	202	6	unravel	unravel	VB
cord-034687-57n88v6t	202	7	the	the	DT
cord-034687-57n88v6t	202	8	complex	complex	JJ
cord-034687-57n88v6t	202	9	circuitry	circuitry	NN
cord-034687-57n88v6t	202	10	involved	involve	VBN
cord-034687-57n88v6t	202	11	in	in	IN
cord-034687-57n88v6t	202	12	the	the	DT
cord-034687-57n88v6t	202	13	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	202	14	modulation	modulation	NN
cord-034687-57n88v6t	202	15	of	of	IN
cord-034687-57n88v6t	202	16	anxiety	anxiety	NN
cord-034687-57n88v6t	202	17	.	.	.
cord-034687-57n88v6t	203	1	BLA	BLA	NNP
cord-034687-57n88v6t	203	2	represents	represent	VBZ
cord-034687-57n88v6t	203	3	a	a	DT
cord-034687-57n88v6t	203	4	critical	critical	JJ
cord-034687-57n88v6t	203	5	brain	brain	NN
cord-034687-57n88v6t	203	6	center	center	NN
cord-034687-57n88v6t	203	7	for	for	IN
cord-034687-57n88v6t	203	8	the	the	DT
cord-034687-57n88v6t	203	9	onset	onset	NN
cord-034687-57n88v6t	203	10	of	of	IN
cord-034687-57n88v6t	203	11	anxiety	anxiety	NN
cord-034687-57n88v6t	203	12	in	in	IN
cord-034687-57n88v6t	203	13	response	response	NN
cord-034687-57n88v6t	203	14	to	to	IN
cord-034687-57n88v6t	203	15	environmental	environmental	JJ
cord-034687-57n88v6t	203	16	cues	cue	NNS
cord-034687-57n88v6t	203	17	.	.	.
cord-034687-57n88v6t	204	1	Systemic	systemic	JJ
cord-034687-57n88v6t	204	2	and	and	CC
cord-034687-57n88v6t	204	3	intra	intra	JJ
cord-034687-57n88v6t	204	4	-	-	JJ
cord-034687-57n88v6t	204	5	amygdalar	amygdalar	JJ
cord-034687-57n88v6t	204	6	administration	administration	NN
cord-034687-57n88v6t	204	7	of	of	IN
cord-034687-57n88v6t	204	8	2-AG	2-ag	CD
cord-034687-57n88v6t	204	9	and	and	CC
cord-034687-57n88v6t	204	10	anandamide	anandamide	NN
cord-034687-57n88v6t	204	11	reuptake	reuptake	NN
cord-034687-57n88v6t	204	12	inhibitors	inhibitor	NNS
cord-034687-57n88v6t	204	13	demonstrate	demonstrate	VBP
cord-034687-57n88v6t	204	14	overlapping	overlap	VBG
cord-034687-57n88v6t	204	15	effects	effect	NNS
cord-034687-57n88v6t	204	16	reducing	reduce	VBG
cord-034687-57n88v6t	204	17	anxiety	anxiety	NN
cord-034687-57n88v6t	204	18	through	through	IN
cord-034687-57n88v6t	204	19	CB	CB	NNP
cord-034687-57n88v6t	204	20	1	1	CD
cord-034687-57n88v6t	204	21	R	r	NN
cord-034687-57n88v6t	204	22	expressed	express	VBN
cord-034687-57n88v6t	204	23	in	in	IN
cord-034687-57n88v6t	204	24	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	204	25	synapses	synapsis	NNS
cord-034687-57n88v6t	204	26	.	.	.
cord-034687-57n88v6t	205	1	[	[	-LRB-
cord-034687-57n88v6t	205	2	55	55	CD
cord-034687-57n88v6t	205	3	]	]	-RRB-
cord-034687-57n88v6t	205	4	[	[	-LRB-
cord-034687-57n88v6t	205	5	56	56	CD
cord-034687-57n88v6t	205	6	]	]	-RRB-
cord-034687-57n88v6t	205	7	[	[	-LRB-
cord-034687-57n88v6t	205	8	57	57	CD
cord-034687-57n88v6t	205	9	]	]	-RRB-
cord-034687-57n88v6t	206	1	At	at	IN
cord-034687-57n88v6t	206	2	least	least	JJS
cord-034687-57n88v6t	206	3	part	part	NN
cord-034687-57n88v6t	206	4	of	of	IN
cord-034687-57n88v6t	206	5	this	this	DT
cord-034687-57n88v6t	206	6	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	206	7	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	206	8	input	input	NN
cord-034687-57n88v6t	206	9	to	to	IN
cord-034687-57n88v6t	206	10	the	the	DT
cord-034687-57n88v6t	206	11	amygdala	amygdala	NN
cord-034687-57n88v6t	206	12	comes	come	VBZ
cord-034687-57n88v6t	206	13	from	from	IN
cord-034687-57n88v6t	206	14	PFC	PFC	NNP
cord-034687-57n88v6t	206	15	and	and	CC
cord-034687-57n88v6t	206	16	hippocampus	hippocampus	NN
cord-034687-57n88v6t	206	17	.	.	.
cord-034687-57n88v6t	207	1	Prelimbic	Prelimbic	NNP
cord-034687-57n88v6t	207	2	PFC	PFC	NNP
cord-034687-57n88v6t	207	3	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	207	4	neurons	neuron	NNS
cord-034687-57n88v6t	207	5	are	be	VBP
cord-034687-57n88v6t	207	6	active	active	JJ
cord-034687-57n88v6t	207	7	after	after	IN
cord-034687-57n88v6t	207	8	threat	threat	NN
cord-034687-57n88v6t	207	9	exposure	exposure	NN
cord-034687-57n88v6t	207	10	,	,	,
cord-034687-57n88v6t	207	11	as	as	IN
cord-034687-57n88v6t	207	12	demonstrated	demonstrate	VBN
cord-034687-57n88v6t	207	13	by	by	IN
cord-034687-57n88v6t	207	14	recent	recent	JJ
cord-034687-57n88v6t	207	15	optogenetic	optogenetic	NNS
cord-034687-57n88v6t	207	16	and	and	CC
cord-034687-57n88v6t	207	17	cell	cell	NN
cord-034687-57n88v6t	207	18	-	-	HYPH
cord-034687-57n88v6t	207	19	specific	specific	JJ
cord-034687-57n88v6t	207	20	gene	gene	NN
cord-034687-57n88v6t	207	21	deletion	deletion	NN
cord-034687-57n88v6t	207	22	experiments	experiment	NNS
cord-034687-57n88v6t	207	23	.	.	.
cord-034687-57n88v6t	208	1	43	43	CD
cord-034687-57n88v6t	209	1	A	a	DT
cord-034687-57n88v6t	209	2	traumatic	traumatic	JJ
cord-034687-57n88v6t	209	3	experience	experience	NN
cord-034687-57n88v6t	209	4	(	(	-LRB-
cord-034687-57n88v6t	209	5	foot	foot	NN
cord-034687-57n88v6t	209	6	-	-	HYPH
cord-034687-57n88v6t	209	7	shock	shock	NN
cord-034687-57n88v6t	209	8	)	)	-RRB-
cord-034687-57n88v6t	209	9	in	in	IN
cord-034687-57n88v6t	209	10	mice	mouse	NNS
cord-034687-57n88v6t	209	11	facilitates	facilitate	VBZ
cord-034687-57n88v6t	209	12	2-AG	2-ag	CD
cord-034687-57n88v6t	209	13	depletion	depletion	NN
cord-034687-57n88v6t	209	14	and	and	CC
cord-034687-57n88v6t	209	15	subsequent	subsequent	JJ
cord-034687-57n88v6t	209	16	enhancement	enhancement	NN
cord-034687-57n88v6t	209	17	of	of	IN
cord-034687-57n88v6t	209	18	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	209	19	neurotransmission	neurotransmission	NN
cord-034687-57n88v6t	209	20	in	in	IN
cord-034687-57n88v6t	209	21	this	this	DT
cord-034687-57n88v6t	209	22	BLA	BLA	NNP
cord-034687-57n88v6t	209	23	-	-	HYPH
cord-034687-57n88v6t	209	24	PFC	PFC	NNP
cord-034687-57n88v6t	209	25	-	-	HYPH
cord-034687-57n88v6t	209	26	BLA	BLA	NNP
cord-034687-57n88v6t	209	27	pathway	pathway	NN
cord-034687-57n88v6t	209	28	to	to	TO
cord-034687-57n88v6t	209	29	trigger	trigger	VB
cord-034687-57n88v6t	209	30	anxiety	anxiety	NN
cord-034687-57n88v6t	209	31	-	-	HYPH
cord-034687-57n88v6t	209	32	like	like	JJ
cord-034687-57n88v6t	209	33	behavior	behavior	NN
cord-034687-57n88v6t	209	34	.	.	.
cord-034687-57n88v6t	210	1	43	43	CD
cord-034687-57n88v6t	211	1	The	the	DT
cord-034687-57n88v6t	211	2	relevance	relevance	NN
cord-034687-57n88v6t	211	3	of	of	IN
cord-034687-57n88v6t	211	4	this	this	DT
cord-034687-57n88v6t	211	5	circuitry	circuitry	NN
cord-034687-57n88v6t	211	6	is	be	VBZ
cord-034687-57n88v6t	211	7	reflected	reflect	VBN
cord-034687-57n88v6t	211	8	in	in	IN
cord-034687-57n88v6t	211	9	clinical	clinical	JJ
cord-034687-57n88v6t	211	10	studies	study	NNS
cord-034687-57n88v6t	211	11	showing	show	VBG
cord-034687-57n88v6t	211	12	that	that	IN
cord-034687-57n88v6t	211	13	the	the	DT
cord-034687-57n88v6t	211	14	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	211	15	effects	effect	NNS
cord-034687-57n88v6t	211	16	of	of	IN
cord-034687-57n88v6t	211	17	THC	thc	NN
cord-034687-57n88v6t	211	18	are	be	VBP
cord-034687-57n88v6t	211	19	associated	associate	VBN
cord-034687-57n88v6t	211	20	with	with	IN
cord-034687-57n88v6t	211	21	reduced	reduced	JJ
cord-034687-57n88v6t	211	22	activity	activity	NN
cord-034687-57n88v6t	211	23	and	and	CC
cord-034687-57n88v6t	211	24	disrupted	disrupt	VBD
cord-034687-57n88v6t	211	25	connectivity	connectivity	NN
cord-034687-57n88v6t	211	26	between	between	IN
cord-034687-57n88v6t	211	27	these	these	DT
cord-034687-57n88v6t	211	28	two	two	CD
cord-034687-57n88v6t	211	29	brain	brain	NN
cord-034687-57n88v6t	211	30	areas	area	NNS
cord-034687-57n88v6t	211	31	.	.	.
cord-034687-57n88v6t	212	1	58	58	CD
cord-034687-57n88v6t	213	1	A	a	DT
cord-034687-57n88v6t	213	2	persistent	persistent	JJ
cord-034687-57n88v6t	213	3	weakening	weakening	NN
cord-034687-57n88v6t	213	4	of	of	IN
cord-034687-57n88v6t	213	5	the	the	DT
cord-034687-57n88v6t	213	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	213	7	tone	tone	NN
cord-034687-57n88v6t	213	8	could	could	MD
cord-034687-57n88v6t	213	9	lead	lead	VB
cord-034687-57n88v6t	213	10	to	to	IN
cord-034687-57n88v6t	213	11	enhanced	enhance	VBN
cord-034687-57n88v6t	213	12	functional	functional	JJ
cord-034687-57n88v6t	213	13	BLA	BLA	NNP
cord-034687-57n88v6t	213	14	-	-	HYPH
cord-034687-57n88v6t	213	15	PFC	PFC	NNP
cord-034687-57n88v6t	213	16	coupling	coupling	NN
cord-034687-57n88v6t	213	17	and	and	CC
cord-034687-57n88v6t	213	18	progression	progression	NN
cord-034687-57n88v6t	213	19	from	from	IN
cord-034687-57n88v6t	213	20	a	a	DT
cord-034687-57n88v6t	213	21	physiological	physiological	JJ
cord-034687-57n88v6t	213	22	stress	stress	NN
cord-034687-57n88v6t	213	23	to	to	IN
cord-034687-57n88v6t	213	24	an	an	DT
cord-034687-57n88v6t	213	25	anxiety	anxiety	NN
cord-034687-57n88v6t	213	26	disorder	disorder	NN
cord-034687-57n88v6t	213	27	.	.	.
cord-034687-57n88v6t	214	1	The	the	DT
cord-034687-57n88v6t	214	2	BLA	BLA	NNP
cord-034687-57n88v6t	214	3	also	also	RB
cord-034687-57n88v6t	214	4	receives	receive	VBZ
cord-034687-57n88v6t	214	5	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	214	6	projections	projection	NNS
cord-034687-57n88v6t	214	7	from	from	IN
cord-034687-57n88v6t	214	8	the	the	DT
cord-034687-57n88v6t	214	9	hippocampus	hippocampus	NN
cord-034687-57n88v6t	214	10	,	,	,
cord-034687-57n88v6t	214	11	and	and	CC
cord-034687-57n88v6t	214	12	these	these	DT
cord-034687-57n88v6t	214	13	projections	projection	NNS
cord-034687-57n88v6t	214	14	are	be	VBP
cord-034687-57n88v6t	214	15	bidirectionally	bidirectionally	RB
cord-034687-57n88v6t	214	16	controlled	control	VBN
cord-034687-57n88v6t	214	17	by	by	IN
cord-034687-57n88v6t	214	18	endocannabinoids	endocannabinoid	NNS
cord-034687-57n88v6t	214	19	.	.	.
cord-034687-57n88v6t	215	1	In	in	IN
cord-034687-57n88v6t	215	2	a	a	DT
cord-034687-57n88v6t	215	3	similar	similar	JJ
cord-034687-57n88v6t	215	4	way	way	NN
cord-034687-57n88v6t	215	5	,	,	,
cord-034687-57n88v6t	215	6	increases	increase	NNS
cord-034687-57n88v6t	215	7	in	in	IN
cord-034687-57n88v6t	215	8	hippocampal	hippocampal	JJ
cord-034687-57n88v6t	215	9	2-AG	2-ag	CD
cord-034687-57n88v6t	215	10	or	or	CC
cord-034687-57n88v6t	215	11	anandamide	anandamide	NN
cord-034687-57n88v6t	215	12	promote	promote	VBP
cord-034687-57n88v6t	215	13	stress	stress	NN
cord-034687-57n88v6t	215	14	resilience	resilience	NN
cord-034687-57n88v6t	215	15	and	and	CC
cord-034687-57n88v6t	215	16	anxiolysis	anxiolysis	NN
cord-034687-57n88v6t	215	17	,	,	,
cord-034687-57n88v6t	215	18	whereas	whereas	IN
cord-034687-57n88v6t	215	19	CB	CB	NNP
cord-034687-57n88v6t	215	20	1	1	CD
cord-034687-57n88v6t	215	21	R	r	NN
cord-034687-57n88v6t	215	22	blockade	blockade	NN
cord-034687-57n88v6t	215	23	or	or	CC
cord-034687-57n88v6t	215	24	inhibition	inhibition	NN
cord-034687-57n88v6t	215	25	of	of	IN
cord-034687-57n88v6t	215	26	2-AG	2-ag	CD
cord-034687-57n88v6t	215	27	production	production	NN
cord-034687-57n88v6t	215	28	precipitates	precipitate	VBZ
cord-034687-57n88v6t	215	29	anxiety	anxiety	NN
cord-034687-57n88v6t	215	30	.	.	.
cord-034687-57n88v6t	216	1	59	59	CD
cord-034687-57n88v6t	216	2	Local	local	JJ
cord-034687-57n88v6t	216	3	CB	CB	NNP
cord-034687-57n88v6t	216	4	1	1	CD
cord-034687-57n88v6t	216	5	R	r	NN
cord-034687-57n88v6t	216	6	activity	activity	NN
cord-034687-57n88v6t	216	7	has	have	VBZ
cord-034687-57n88v6t	216	8	also	also	RB
cord-034687-57n88v6t	216	9	been	be	VBN
cord-034687-57n88v6t	216	10	associated	associate	VBN
cord-034687-57n88v6t	216	11	with	with	IN
cord-034687-57n88v6t	216	12	anxiogenesis	anxiogenesis	NN
cord-034687-57n88v6t	216	13	in	in	IN
cord-034687-57n88v6t	216	14	certain	certain	JJ
cord-034687-57n88v6t	216	15	circuits	circuit	NNS
cord-034687-57n88v6t	216	16	.	.	.
cord-034687-57n88v6t	217	1	Thus	thus	RB
cord-034687-57n88v6t	217	2	,	,	,
cord-034687-57n88v6t	217	3	the	the	DT
cord-034687-57n88v6t	217	4	amygdala	amygdala	NN
cord-034687-57n88v6t	217	5	sends	send	VBZ
cord-034687-57n88v6t	217	6	CB	CB	NNP
cord-034687-57n88v6t	217	7	1	1	CD
cord-034687-57n88v6t	217	8	R	r	NN
cord-034687-57n88v6t	217	9	-positive	-positive	CD
cord-034687-57n88v6t	217	10	projections	projection	NNS
cord-034687-57n88v6t	217	11	to	to	IN
cord-034687-57n88v6t	217	12	the	the	DT
cord-034687-57n88v6t	217	13	bed	bed	NN
cord-034687-57n88v6t	217	14	nucleus	nucleus	NN
cord-034687-57n88v6t	217	15	of	of	IN
cord-034687-57n88v6t	217	16	the	the	DT
cord-034687-57n88v6t	217	17	stria	stria	NN
cord-034687-57n88v6t	217	18	terminalis	terminalis	NN
cord-034687-57n88v6t	217	19	(	(	-LRB-
cord-034687-57n88v6t	217	20	BNST	BNST	NNP
cord-034687-57n88v6t	217	21	)	)	-RRB-
cord-034687-57n88v6t	217	22	,	,	,
cord-034687-57n88v6t	217	23	a	a	DT
cord-034687-57n88v6t	217	24	brain	brain	NN
cord-034687-57n88v6t	217	25	region	region	NN
cord-034687-57n88v6t	217	26	closely	closely	RB
cord-034687-57n88v6t	217	27	involved	involve	VBN
cord-034687-57n88v6t	217	28	in	in	IN
cord-034687-57n88v6t	217	29	anxiety	anxiety	NN
cord-034687-57n88v6t	217	30	.	.	.
cord-034687-57n88v6t	218	1	This	this	DT
cord-034687-57n88v6t	218	2	area	area	NN
cord-034687-57n88v6t	218	3	is	be	VBZ
cord-034687-57n88v6t	218	4	connected	connect	VBN
cord-034687-57n88v6t	218	5	with	with	IN
cord-034687-57n88v6t	218	6	midbrain	midbrain	NN
cord-034687-57n88v6t	218	7	structures	structure	NNS
cord-034687-57n88v6t	218	8	,	,	,
cord-034687-57n88v6t	218	9	including	include	VBG
cord-034687-57n88v6t	218	10	the	the	DT
cord-034687-57n88v6t	218	11	ventral	ventral	JJ
cord-034687-57n88v6t	218	12	tegmental	tegmental	JJ
cord-034687-57n88v6t	218	13	area	area	NN
cord-034687-57n88v6t	218	14	and	and	CC
cord-034687-57n88v6t	218	15	the	the	DT
cord-034687-57n88v6t	218	16	locus	locus	NN
cord-034687-57n88v6t	218	17	coeruleus	coeruleu	VBZ
cord-034687-57n88v6t	218	18	.	.	.
cord-034687-57n88v6t	219	1	Glutamatergic	Glutamatergic	NNP
cord-034687-57n88v6t	219	2	and	and	CC
cord-034687-57n88v6t	219	3	GABAergic	gabaergic	JJ
cord-034687-57n88v6t	219	4	projections	projection	NNS
cord-034687-57n88v6t	219	5	from	from	IN
cord-034687-57n88v6t	219	6	the	the	DT
cord-034687-57n88v6t	219	7	amygdala	amygdala	NN
cord-034687-57n88v6t	219	8	to	to	IN
cord-034687-57n88v6t	219	9	BNST	BNST	NNP
cord-034687-57n88v6t	219	10	are	be	VBP
cord-034687-57n88v6t	219	11	each	each	DT
cord-034687-57n88v6t	219	12	sufficient	sufficient	JJ
cord-034687-57n88v6t	219	13	for	for	IN
cord-034687-57n88v6t	219	14	the	the	DT
cord-034687-57n88v6t	219	15	development	development	NN
cord-034687-57n88v6t	219	16	of	of	IN
cord-034687-57n88v6t	219	17	anxious	anxious	JJ
cord-034687-57n88v6t	219	18	responses	response	NNS
cord-034687-57n88v6t	219	19	to	to	IN
cord-034687-57n88v6t	219	20	unpredictable	unpredictable	JJ
cord-034687-57n88v6t	219	21	stimuli	stimulus	NNS
cord-034687-57n88v6t	219	22	.	.	.
cord-034687-57n88v6t	220	1	CB	CB	NNP
cord-034687-57n88v6t	220	2	1	1	CD
cord-034687-57n88v6t	220	3	R	r	NN
cord-034687-57n88v6t	220	4	activity	activity	NN
cord-034687-57n88v6t	220	5	in	in	IN
cord-034687-57n88v6t	220	6	these	these	DT
cord-034687-57n88v6t	220	7	projections	projection	NNS
cord-034687-57n88v6t	220	8	seems	seem	VBZ
cord-034687-57n88v6t	220	9	essential	essential	JJ
cord-034687-57n88v6t	220	10	for	for	IN
cord-034687-57n88v6t	220	11	the	the	DT
cord-034687-57n88v6t	220	12	shift	shift	NN
cord-034687-57n88v6t	220	13	from	from	IN
cord-034687-57n88v6t	220	14	phasic	phasic	JJ
cord-034687-57n88v6t	220	15	to	to	IN
cord-034687-57n88v6t	220	16	sustained	sustained	JJ
cord-034687-57n88v6t	220	17	fear	fear	NN
cord-034687-57n88v6t	220	18	responses	response	NNS
cord-034687-57n88v6t	220	19	in	in	IN
cord-034687-57n88v6t	220	20	fear	fear	NN
cord-034687-57n88v6t	220	21	conditioning	conditioning	NN
cord-034687-57n88v6t	220	22	chambers	chamber	NNS
cord-034687-57n88v6t	220	23	,	,	,
cord-034687-57n88v6t	220	24	interpreted	interpret	VBD
cord-034687-57n88v6t	220	25	as	as	IN
cord-034687-57n88v6t	220	26	a	a	DT
cord-034687-57n88v6t	220	27	reminiscence	reminiscence	NN
cord-034687-57n88v6t	220	28	of	of	IN
cord-034687-57n88v6t	220	29	the	the	DT
cord-034687-57n88v6t	220	30	human	human	JJ
cord-034687-57n88v6t	220	31	anxiety	anxiety	NN
cord-034687-57n88v6t	220	32	against	against	IN
cord-034687-57n88v6t	220	33	unpredictable	unpredictable	JJ
cord-034687-57n88v6t	220	34	threats	threat	NNS
cord-034687-57n88v6t	220	35	.	.	.
cord-034687-57n88v6t	221	1	60	60	CD
cord-034687-57n88v6t	222	1	In	in	IN
cord-034687-57n88v6t	222	2	the	the	DT
cord-034687-57n88v6t	222	3	context	context	NN
cord-034687-57n88v6t	222	4	of	of	IN
cord-034687-57n88v6t	222	5	an	an	DT
cord-034687-57n88v6t	222	6	established	establish	VBN
cord-034687-57n88v6t	222	7	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	222	8	response	response	NN
cord-034687-57n88v6t	222	9	,	,	,
cord-034687-57n88v6t	222	10	blocking	block	VBG
cord-034687-57n88v6t	222	11	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	222	12	activity	activity	NN
cord-034687-57n88v6t	222	13	in	in	IN
cord-034687-57n88v6t	222	14	the	the	DT
cord-034687-57n88v6t	222	15	BNST	BNST	NNP
cord-034687-57n88v6t	222	16	facilitates	facilitate	VBZ
cord-034687-57n88v6t	222	17	the	the	DT
cord-034687-57n88v6t	222	18	transition	transition	NN
cord-034687-57n88v6t	222	19	from	from	IN
cord-034687-57n88v6t	222	20	persistent	persistent	JJ
cord-034687-57n88v6t	222	21	to	to	IN
cord-034687-57n88v6t	222	22	phasic	phasic	JJ
cord-034687-57n88v6t	222	23	freezing	freezing	JJ
cord-034687-57n88v6t	222	24	responses	response	NNS
cord-034687-57n88v6t	222	25	,	,	,
cord-034687-57n88v6t	222	26	a	a	DT
cord-034687-57n88v6t	222	27	switch	switch	NN
cord-034687-57n88v6t	222	28	that	that	WDT
cord-034687-57n88v6t	222	29	could	could	MD
cord-034687-57n88v6t	222	30	allow	allow	VB
cord-034687-57n88v6t	222	31	earlier	early	JJR
cord-034687-57n88v6t	222	32	reinstatement	reinstatement	NN
cord-034687-57n88v6t	222	33	of	of	IN
cord-034687-57n88v6t	222	34	normal	normal	JJ
cord-034687-57n88v6t	222	35	anxious	anxious	JJ
cord-034687-57n88v6t	222	36	behavior	behavior	NN
cord-034687-57n88v6t	222	37	.	.	.
cord-034687-57n88v6t	223	1	A	a	DT
cord-034687-57n88v6t	223	2	cooperation	cooperation	NN
cord-034687-57n88v6t	223	3	between	between	IN
cord-034687-57n88v6t	223	4	the	the	DT
cord-034687-57n88v6t	223	5	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	223	6	and	and	CC
cord-034687-57n88v6t	223	7	monoaminergic	monoaminergic	JJ
cord-034687-57n88v6t	223	8	systems	system	NNS
cord-034687-57n88v6t	223	9	is	be	VBZ
cord-034687-57n88v6t	223	10	required	require	VBN
cord-034687-57n88v6t	223	11	for	for	IN
cord-034687-57n88v6t	223	12	anxiety	anxiety	NN
cord-034687-57n88v6t	223	13	modulation	modulation	NN
cord-034687-57n88v6t	223	14	.	.	.
cord-034687-57n88v6t	224	1	61	61	CD
cord-034687-57n88v6t	225	1	At	at	IN
cord-034687-57n88v6t	225	2	a	a	DT
cord-034687-57n88v6t	225	3	molecular	molecular	JJ
cord-034687-57n88v6t	225	4	level	level	NN
cord-034687-57n88v6t	225	5	,	,	,
cord-034687-57n88v6t	225	6	heterodimers	heterodimer	NNS
cord-034687-57n88v6t	225	7	composed	compose	VBN
cord-034687-57n88v6t	225	8	of	of	IN
cord-034687-57n88v6t	225	9	CB	CB	NNP
cord-034687-57n88v6t	225	10	1	1	CD
cord-034687-57n88v6t	225	11	R	r	NN
cord-034687-57n88v6t	225	12	and	and	CC
cord-034687-57n88v6t	225	13	5-HT	5-ht	CD
cord-034687-57n88v6t	225	14	2A	2a	CD
cord-034687-57n88v6t	225	15	receptors	receptor	NNS
cord-034687-57n88v6t	225	16	are	be	VBP
cord-034687-57n88v6t	225	17	essential	essential	JJ
cord-034687-57n88v6t	225	18	for	for	IN
cord-034687-57n88v6t	225	19	the	the	DT
cord-034687-57n88v6t	225	20	effects	effect	NNS
cord-034687-57n88v6t	225	21	of	of	IN
cord-034687-57n88v6t	225	22	THC	thc	NN
cord-034687-57n88v6t	225	23	promoting	promote	VBG
cord-034687-57n88v6t	225	24	anxiolysis	anxiolysis	NN
cord-034687-57n88v6t	225	25	and	and	CC
cord-034687-57n88v6t	225	26	social	social	JJ
cord-034687-57n88v6t	225	27	interaction	interaction	NN
cord-034687-57n88v6t	225	28	.	.	.
cord-034687-57n88v6t	226	1	61	61	CD
cord-034687-57n88v6t	227	1	In	in	IN
cord-034687-57n88v6t	227	2	agreement	agreement	NN
cord-034687-57n88v6t	227	3	with	with	IN
cord-034687-57n88v6t	227	4	this	this	DT
cord-034687-57n88v6t	227	5	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	227	6	-	-	HYPH
cord-034687-57n88v6t	227	7	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	227	8	interaction	interaction	NN
cord-034687-57n88v6t	227	9	,	,	,
cord-034687-57n88v6t	227	10	deleting	delete	VBG
cord-034687-57n88v6t	227	11	CB	CB	NNP
cord-034687-57n88v6t	227	12	1	1	CD
cord-034687-57n88v6t	227	13	R	r	NN
cord-034687-57n88v6t	227	14	from	from	IN
cord-034687-57n88v6t	227	15	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	227	16	neurons	neuron	NNS
cord-034687-57n88v6t	227	17	of	of	IN
cord-034687-57n88v6t	227	18	the	the	DT
cord-034687-57n88v6t	227	19	raphe	raphe	NN
cord-034687-57n88v6t	227	20	nuclei	nuclei	VBZ
cord-034687-57n88v6t	227	21	leads	lead	VBZ
cord-034687-57n88v6t	227	22	to	to	IN
cord-034687-57n88v6t	227	23	decreased	decrease	VBN
cord-034687-57n88v6t	227	24	social	social	JJ
cord-034687-57n88v6t	227	25	interaction	interaction	NN
cord-034687-57n88v6t	227	26	and	and	CC
cord-034687-57n88v6t	227	27	enhanced	enhanced	JJ
cord-034687-57n88v6t	227	28	anxiety	anxiety	NN
cord-034687-57n88v6t	227	29	-	-	HYPH
cord-034687-57n88v6t	227	30	like	like	JJ
cord-034687-57n88v6t	227	31	behavior	behavior	NN
cord-034687-57n88v6t	227	32	in	in	IN
cord-034687-57n88v6t	227	33	a	a	DT
cord-034687-57n88v6t	227	34	novelty	novelty	NN
cord-034687-57n88v6t	227	35	-	-	HYPH
cord-034687-57n88v6t	227	36	suppressed	suppress	VBN
cord-034687-57n88v6t	227	37	feeding	feeding	NN
cord-034687-57n88v6t	227	38	test	test	NN
cord-034687-57n88v6t	227	39	.	.	.
cord-034687-57n88v6t	228	1	62	62	CD
cord-034687-57n88v6t	228	2	Close	close	JJ
cord-034687-57n88v6t	228	3	coordination	coordination	NN
cord-034687-57n88v6t	228	4	between	between	IN
cord-034687-57n88v6t	228	5	both	both	DT
cord-034687-57n88v6t	228	6	systems	system	NNS
cord-034687-57n88v6t	228	7	has	have	VBZ
cord-034687-57n88v6t	228	8	also	also	RB
cord-034687-57n88v6t	228	9	been	be	VBN
cord-034687-57n88v6t	228	10	reported	report	VBN
cord-034687-57n88v6t	228	11	at	at	IN
cord-034687-57n88v6t	228	12	a	a	DT
cord-034687-57n88v6t	228	13	circuit	circuit	NN
cord-034687-57n88v6t	228	14	level	level	NN
cord-034687-57n88v6t	228	15	.	.	.
cord-034687-57n88v6t	229	1	CB	CB	NNP
cord-034687-57n88v6t	229	2	1	1	CD
cord-034687-57n88v6t	229	3	R	r	NN
cord-034687-57n88v6t	229	4	-	-	HYPH
cord-034687-57n88v6t	229	5	expressing	express	VBG
cord-034687-57n88v6t	229	6	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	229	7	neurons	neuron	NNS
cord-034687-57n88v6t	229	8	of	of	IN
cord-034687-57n88v6t	229	9	the	the	DT
cord-034687-57n88v6t	229	10	PFC	PFC	NNP
cord-034687-57n88v6t	229	11	synapse	synapse	NN
cord-034687-57n88v6t	229	12	with	with	IN
cord-034687-57n88v6t	229	13	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	229	14	and	and	CC
cord-034687-57n88v6t	229	15	GABAergic	gabaergic	JJ
cord-034687-57n88v6t	229	16	neurons	neuron	NNS
cord-034687-57n88v6t	229	17	in	in	IN
cord-034687-57n88v6t	229	18	the	the	DT
cord-034687-57n88v6t	229	19	dorsal	dorsal	JJ
cord-034687-57n88v6t	229	20	raphe	raphe	NN
cord-034687-57n88v6t	229	21	nuclei	nucleus	NNS
cord-034687-57n88v6t	229	22	.	.	.
cord-034687-57n88v6t	230	1	Optogenetic	optogenetic	JJ
cord-034687-57n88v6t	230	2	approaches	approach	NNS
cord-034687-57n88v6t	230	3	have	have	VBP
cord-034687-57n88v6t	230	4	revealed	reveal	VBN
cord-034687-57n88v6t	230	5	that	that	IN
cord-034687-57n88v6t	230	6	dorsal	dorsal	JJ
cord-034687-57n88v6t	230	7	raphe	raphe	NN
cord-034687-57n88v6t	230	8	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	230	9	synapses	synapsis	NNS
cord-034687-57n88v6t	230	10	are	be	VBP
cord-034687-57n88v6t	230	11	more	more	RBR
cord-034687-57n88v6t	230	12	sensitive	sensitive	JJ
cord-034687-57n88v6t	230	13	to	to	IN
cord-034687-57n88v6t	230	14	the	the	DT
cord-034687-57n88v6t	230	15	inhibitory	inhibitory	JJ
cord-034687-57n88v6t	230	16	effect	effect	NN
cord-034687-57n88v6t	230	17	of	of	IN
cord-034687-57n88v6t	230	18	CB	CB	NNP
cord-034687-57n88v6t	230	19	1	1	CD
cord-034687-57n88v6t	230	20	R	r	NN
cord-034687-57n88v6t	230	21	activity	activity	NN
cord-034687-57n88v6t	230	22	than	than	IN
cord-034687-57n88v6t	230	23	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	230	24	neurons	neuron	NNS
cord-034687-57n88v6t	230	25	.	.	.
cord-034687-57n88v6t	231	1	As	as	IN
cord-034687-57n88v6t	231	2	a	a	DT
cord-034687-57n88v6t	231	3	consequence	consequence	NN
cord-034687-57n88v6t	231	4	,	,	,
cord-034687-57n88v6t	231	5	CB	CB	NNP
cord-034687-57n88v6t	231	6	1	1	CD
cord-034687-57n88v6t	231	7	R	r	NN
cord-034687-57n88v6t	231	8	stimulation	stimulation	NN
cord-034687-57n88v6t	231	9	provokes	provoke	VBZ
cord-034687-57n88v6t	231	10	a	a	DT
cord-034687-57n88v6t	231	11	net	net	JJ
cord-034687-57n88v6t	231	12	increase	increase	NN
cord-034687-57n88v6t	231	13	of	of	IN
cord-034687-57n88v6t	231	14	5-HT	5-ht	CD
cord-034687-57n88v6t	231	15	output	output	NN
cord-034687-57n88v6t	231	16	from	from	IN
cord-034687-57n88v6t	231	17	the	the	DT
cord-034687-57n88v6t	231	18	dorsal	dorsal	JJ
cord-034687-57n88v6t	231	19	raphe	raphe	NN
cord-034687-57n88v6t	231	20	nuclei	nucleus	NNS
cord-034687-57n88v6t	231	21	.	.	.
cord-034687-57n88v6t	232	1	63	63	CD
cord-034687-57n88v6t	233	1	In	in	IN
cord-034687-57n88v6t	233	2	a	a	DT
cord-034687-57n88v6t	233	3	related	related	JJ
cord-034687-57n88v6t	233	4	circuit	circuit	NN
cord-034687-57n88v6t	233	5	,	,	,
cord-034687-57n88v6t	233	6	CB	CB	NNP
cord-034687-57n88v6t	233	7	1	1	CD
cord-034687-57n88v6t	233	8	R	r	NN
cord-034687-57n88v6t	233	9	stimulation	stimulation	NN
cord-034687-57n88v6t	233	10	shows	show	VBZ
cord-034687-57n88v6t	233	11	opposite	opposite	JJ
cord-034687-57n88v6t	233	12	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	233	13	effects	effect	NNS
cord-034687-57n88v6t	233	14	controlling	control	VBG
cord-034687-57n88v6t	233	15	the	the	DT
cord-034687-57n88v6t	233	16	lateral	lateral	JJ
cord-034687-57n88v6t	233	17	habenula	habenula	NN
cord-034687-57n88v6t	233	18	,	,	,
cord-034687-57n88v6t	233	19	an	an	DT
cord-034687-57n88v6t	233	20	area	area	NN
cord-034687-57n88v6t	233	21	that	that	WDT
cord-034687-57n88v6t	233	22	integrates	integrate	VBZ
cord-034687-57n88v6t	233	23	stimuli	stimulus	NNS
cord-034687-57n88v6t	233	24	from	from	IN
cord-034687-57n88v6t	233	25	basal	basal	NN
cord-034687-57n88v6t	233	26	ganglia	ganglion	NNS
cord-034687-57n88v6t	233	27	and	and	CC
cord-034687-57n88v6t	233	28	limbic	limbic	JJ
cord-034687-57n88v6t	233	29	system	system	NN
cord-034687-57n88v6t	233	30	and	and	CC
cord-034687-57n88v6t	233	31	sends	send	VBZ
cord-034687-57n88v6t	233	32	output	output	NN
cord-034687-57n88v6t	233	33	signals	signal	NNS
cord-034687-57n88v6t	233	34	to	to	IN
cord-034687-57n88v6t	233	35	dopamine	dopamine	NN
cord-034687-57n88v6t	233	36	and	and	CC
cord-034687-57n88v6t	233	37	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	233	38	neurons	neuron	NNS
cord-034687-57n88v6t	233	39	of	of	IN
cord-034687-57n88v6t	233	40	the	the	DT
cord-034687-57n88v6t	233	41	ventral	ventral	JJ
cord-034687-57n88v6t	233	42	tegmental	tegmental	JJ
cord-034687-57n88v6t	233	43	area	area	NN
cord-034687-57n88v6t	233	44	.	.	.
cord-034687-57n88v6t	234	1	64	64	CD
cord-034687-57n88v6t	235	1	Blocking	block	VBG
cord-034687-57n88v6t	235	2	habenular	habenular	JJ
cord-034687-57n88v6t	235	3	CB	CB	NNP
cord-034687-57n88v6t	235	4	1	1	CD
cord-034687-57n88v6t	236	1	R	r	NN
cord-034687-57n88v6t	236	2	augments	augment	VBZ
cord-034687-57n88v6t	236	3	proactive	proactive	JJ
cord-034687-57n88v6t	236	4	coping	cope	VBG
cord-034687-57n88v6t	236	5	behaviors	behavior	NNS
cord-034687-57n88v6t	236	6	to	to	TO
cord-034687-57n88v6t	236	7	reduce	reduce	VB
cord-034687-57n88v6t	236	8	social	social	JJ
cord-034687-57n88v6t	236	9	stress	stress	NN
cord-034687-57n88v6t	236	10	and	and	CC
cord-034687-57n88v6t	236	11	diminishes	diminish	VBZ
cord-034687-57n88v6t	236	12	anxiety	anxiety	NN
cord-034687-57n88v6t	236	13	-	-	HYPH
cord-034687-57n88v6t	236	14	like	like	JJ
cord-034687-57n88v6t	236	15	behavior	behavior	NN
cord-034687-57n88v6t	236	16	.	.	.
cord-034687-57n88v6t	237	1	With	with	IN
cord-034687-57n88v6t	237	2	cooperation	cooperation	NN
cord-034687-57n88v6t	237	3	between	between	IN
cord-034687-57n88v6t	237	4	monoaminergic	monoaminergic	NNP
cord-034687-57n88v6t	237	5	and	and	CC
cord-034687-57n88v6t	237	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	237	7	systems	system	NNS
cord-034687-57n88v6t	237	8	starting	start	VBG
cord-034687-57n88v6t	237	9	to	to	TO
cord-034687-57n88v6t	237	10	be	be	VB
cord-034687-57n88v6t	237	11	untangled	untangle	VBN
cord-034687-57n88v6t	237	12	,	,	,
cord-034687-57n88v6t	237	13	it	-PRON-	PRP
cord-034687-57n88v6t	237	14	will	will	MD
cord-034687-57n88v6t	237	15	probably	probably	RB
cord-034687-57n88v6t	237	16	constitute	constitute	VB
cord-034687-57n88v6t	237	17	an	an	DT
cord-034687-57n88v6t	237	18	additional	additional	JJ
cord-034687-57n88v6t	237	19	source	source	NN
cord-034687-57n88v6t	237	20	of	of	IN
cord-034687-57n88v6t	237	21	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	237	22	exploitation	exploitation	NN
cord-034687-57n88v6t	237	23	for	for	IN
cord-034687-57n88v6t	237	24	anxiety	anxiety	NN
cord-034687-57n88v6t	237	25	disorders	disorder	NNS
cord-034687-57n88v6t	237	26	.	.	.
cord-034687-57n88v6t	238	1	Preexisting	preexisting	JJ
cord-034687-57n88v6t	238	2	conditions	condition	NNS
cord-034687-57n88v6t	238	3	can	can	MD
cord-034687-57n88v6t	238	4	modify	modify	VB
cord-034687-57n88v6t	238	5	the	the	DT
cord-034687-57n88v6t	238	6	effects	effect	NNS
cord-034687-57n88v6t	238	7	of	of	IN
cord-034687-57n88v6t	238	8	the	the	DT
cord-034687-57n88v6t	238	9	manipulation	manipulation	NN
cord-034687-57n88v6t	238	10	of	of	IN
cord-034687-57n88v6t	238	11	the	the	DT
cord-034687-57n88v6t	238	12	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	238	13	system	system	NN
cord-034687-57n88v6t	238	14	on	on	IN
cord-034687-57n88v6t	238	15	anxiety	anxiety	NN
cord-034687-57n88v6t	238	16	.	.	.
cord-034687-57n88v6t	239	1	Thus	thus	RB
cord-034687-57n88v6t	239	2	,	,	,
cord-034687-57n88v6t	239	3	a	a	DT
cord-034687-57n88v6t	239	4	state	state	NN
cord-034687-57n88v6t	239	5	of	of	IN
cord-034687-57n88v6t	239	6	low	low	JJ
cord-034687-57n88v6t	239	7	arousal	arousal	NN
cord-034687-57n88v6t	239	8	allows	allow	VBZ
cord-034687-57n88v6t	239	9	anxiety	anxiety	NN
cord-034687-57n88v6t	239	10	relief	relief	NN
cord-034687-57n88v6t	239	11	after	after	IN
cord-034687-57n88v6t	239	12	potentiation	potentiation	NN
cord-034687-57n88v6t	239	13	of	of	IN
cord-034687-57n88v6t	239	14	amygdala	amygdala	NN
cord-034687-57n88v6t	239	15	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	239	16	neurotransmission	neurotransmission	NN
cord-034687-57n88v6t	239	17	(	(	-LRB-
cord-034687-57n88v6t	239	18	2-AG	2-ag	CD
cord-034687-57n88v6t	239	19	or	or	CC
cord-034687-57n88v6t	239	20	anandamide	anandamide	NN
cord-034687-57n88v6t	239	21	)	)	-RRB-
cord-034687-57n88v6t	239	22	,	,	,
cord-034687-57n88v6t	239	23	whereas	whereas	IN
cord-034687-57n88v6t	239	24	high	high	JJ
cord-034687-57n88v6t	239	25	arousal	arousal	NN
cord-034687-57n88v6t	239	26	conditions	condition	NNS
cord-034687-57n88v6t	239	27	prevent	prevent	VBP
cord-034687-57n88v6t	239	28	this	this	DT
cord-034687-57n88v6t	239	29	effect	effect	NN
cord-034687-57n88v6t	239	30	.	.	.
cord-034687-57n88v6t	240	1	33	33	CD
cord-034687-57n88v6t	240	2	Protracted	protracted	JJ
cord-034687-57n88v6t	240	3	consequences	consequence	NNS
cord-034687-57n88v6t	240	4	of	of	IN
cord-034687-57n88v6t	240	5	cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	240	6	have	have	VBP
cord-034687-57n88v6t	240	7	been	be	VBN
cord-034687-57n88v6t	240	8	revealed	reveal	VBN
cord-034687-57n88v6t	240	9	when	when	WRB
cord-034687-57n88v6t	240	10	administered	administer	VBN
cord-034687-57n88v6t	240	11	shortly	shortly	RB
cord-034687-57n88v6t	240	12	after	after	IN
cord-034687-57n88v6t	240	13	threat	threat	NN
cord-034687-57n88v6t	240	14	exposure	exposure	NN
cord-034687-57n88v6t	240	15	.	.	.
cord-034687-57n88v6t	241	1	Thus	thus	RB
cord-034687-57n88v6t	241	2	,	,	,
cord-034687-57n88v6t	241	3	functional	functional	JJ
cord-034687-57n88v6t	241	4	magnetic	magnetic	JJ
cord-034687-57n88v6t	241	5	resonance	resonance	NN
cord-034687-57n88v6t	241	6	imaging	imaging	NN
cord-034687-57n88v6t	241	7	(	(	-LRB-
cord-034687-57n88v6t	241	8	fMRI	fMRI	NNP
cord-034687-57n88v6t	241	9	)	)	-RRB-
cord-034687-57n88v6t	241	10	in	in	IN
cord-034687-57n88v6t	241	11	humans	human	NNS
cord-034687-57n88v6t	241	12	has	have	VBZ
cord-034687-57n88v6t	241	13	shown	show	VBN
cord-034687-57n88v6t	241	14	that	that	IN
cord-034687-57n88v6t	241	15	single	single	JJ
cord-034687-57n88v6t	241	16	THC	thc	NN
cord-034687-57n88v6t	241	17	exposures	exposure	NNS
cord-034687-57n88v6t	241	18	after	after	IN
cord-034687-57n88v6t	241	19	threatening	threaten	VBG
cord-034687-57n88v6t	241	20	stimuli	stimulus	NNS
cord-034687-57n88v6t	241	21	have	have	VBP
cord-034687-57n88v6t	241	22	perceptible	perceptible	JJ
cord-034687-57n88v6t	241	23	effects	effect	NNS
cord-034687-57n88v6t	241	24	1	1	CD
cord-034687-57n88v6t	241	25	week	week	NN
cord-034687-57n88v6t	241	26	later	later	RB
cord-034687-57n88v6t	241	27	.	.	.
cord-034687-57n88v6t	242	1	These	these	DT
cord-034687-57n88v6t	242	2	effects	effect	NNS
cord-034687-57n88v6t	242	3	consist	consist	VBP
cord-034687-57n88v6t	242	4	of	of	IN
cord-034687-57n88v6t	242	5	decreased	decrease	VBN
cord-034687-57n88v6t	242	6	amygdala	amygdala	NNP
cord-034687-57n88v6t	242	7	-	-	HYPH
cord-034687-57n88v6t	242	8	PFC	PFC	NNP
cord-034687-57n88v6t	242	9	activity	activity	NN
cord-034687-57n88v6t	242	10	and	and	CC
cord-034687-57n88v6t	242	11	reduced	reduce	VBN
cord-034687-57n88v6t	242	12	functional	functional	JJ
cord-034687-57n88v6t	242	13	coupling	coupling	NN
cord-034687-57n88v6t	242	14	among	among	IN
cord-034687-57n88v6t	242	15	PFC	PFC	NNP
cord-034687-57n88v6t	242	16	,	,	,
cord-034687-57n88v6t	242	17	hippocampus	hippocampus	NN
cord-034687-57n88v6t	242	18	,	,	,
cord-034687-57n88v6t	242	19	and	and	CC
cord-034687-57n88v6t	242	20	dorsal	dorsal	JJ
cord-034687-57n88v6t	242	21	anterior	anterior	NNP
cord-034687-57n88v6t	242	22	cingulate	cingulate	NNP
cord-034687-57n88v6t	242	23	cortex	cortex	NNP
cord-034687-57n88v6t	242	24	,	,	,
cord-034687-57n88v6t	242	25	a	a	DT
cord-034687-57n88v6t	242	26	network	network	NN
cord-034687-57n88v6t	242	27	involved	involve	VBN
cord-034687-57n88v6t	242	28	in	in	IN
cord-034687-57n88v6t	242	29	the	the	DT
cord-034687-57n88v6t	242	30	extinction	extinction	NN
cord-034687-57n88v6t	242	31	of	of	IN
cord-034687-57n88v6t	242	32	aversive	aversive	JJ
cord-034687-57n88v6t	242	33	memories	memory	NNS
cord-034687-57n88v6t	242	34	.	.	.
cord-034687-57n88v6t	243	1	58	58	CD
cord-034687-57n88v6t	244	1	Thus	thus	RB
cord-034687-57n88v6t	244	2	,	,	,
cord-034687-57n88v6t	244	3	the	the	DT
cord-034687-57n88v6t	244	4	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	244	5	effects	effect	NNS
cord-034687-57n88v6t	244	6	of	of	IN
cord-034687-57n88v6t	244	7	cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	244	8	depend	depend	VBP
cord-034687-57n88v6t	244	9	on	on	IN
cord-034687-57n88v6t	244	10	the	the	DT
cord-034687-57n88v6t	244	11	quality	quality	NN
cord-034687-57n88v6t	244	12	and	and	CC
cord-034687-57n88v6t	244	13	timing	timing	NN
cord-034687-57n88v6t	244	14	of	of	IN
cord-034687-57n88v6t	244	15	the	the	DT
cord-034687-57n88v6t	244	16	threats	threat	NNS
cord-034687-57n88v6t	244	17	and	and	CC
cord-034687-57n88v6t	244	18	could	could	MD
cord-034687-57n88v6t	244	19	have	have	VB
cord-034687-57n88v6t	244	20	delayed	delay	VBN
cord-034687-57n88v6t	244	21	effects	effect	NNS
cord-034687-57n88v6t	244	22	on	on	IN
cord-034687-57n88v6t	244	23	the	the	DT
cord-034687-57n88v6t	244	24	expression	expression	NN
cord-034687-57n88v6t	244	25	or	or	CC
cord-034687-57n88v6t	244	26	extinction	extinction	NN
cord-034687-57n88v6t	244	27	of	of	IN
cord-034687-57n88v6t	244	28	anxiety	anxiety	NN
cord-034687-57n88v6t	244	29	-	-	HYPH
cord-034687-57n88v6t	244	30	related	relate	VBN
cord-034687-57n88v6t	244	31	behavior	behavior	NN
cord-034687-57n88v6t	244	32	,	,	,
cord-034687-57n88v6t	244	33	not	not	RB
cord-034687-57n88v6t	244	34	detectable	detectable	JJ
cord-034687-57n88v6t	244	35	immediately	immediately	RB
cord-034687-57n88v6t	244	36	after	after	IN
cord-034687-57n88v6t	244	37	the	the	DT
cord-034687-57n88v6t	244	38	treatments	treatment	NNS
cord-034687-57n88v6t	244	39	.	.	.
cord-034687-57n88v6t	245	1	Age	age	NN
cord-034687-57n88v6t	245	2	and	and	CC
cord-034687-57n88v6t	245	3	sex	sex	NN
cord-034687-57n88v6t	245	4	of	of	IN
cord-034687-57n88v6t	245	5	individuals	individual	NNS
cord-034687-57n88v6t	245	6	are	be	VBP
cord-034687-57n88v6t	245	7	important	important	JJ
cord-034687-57n88v6t	245	8	determinants	determinant	NNS
cord-034687-57n88v6t	245	9	for	for	IN
cord-034687-57n88v6t	245	10	the	the	DT
cord-034687-57n88v6t	245	11	consequences	consequence	NNS
cord-034687-57n88v6t	245	12	of	of	IN
cord-034687-57n88v6t	245	13	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	245	14	exposure	exposure	NN
cord-034687-57n88v6t	245	15	on	on	IN
cord-034687-57n88v6t	245	16	anxiety	anxiety	NN
cord-034687-57n88v6t	245	17	.	.	.
cord-034687-57n88v6t	246	1	65	65	CD
cord-034687-57n88v6t	246	2	Women	woman	NNS
cord-034687-57n88v6t	246	3	present	present	VBP
cord-034687-57n88v6t	246	4	an	an	DT
cord-034687-57n88v6t	246	5	increased	increased	JJ
cord-034687-57n88v6t	246	6	propensity	propensity	NN
cord-034687-57n88v6t	246	7	to	to	IN
cord-034687-57n88v6t	246	8	anxiety	anxiety	NN
cord-034687-57n88v6t	246	9	-	-	HYPH
cord-034687-57n88v6t	246	10	related	relate	VBN
cord-034687-57n88v6t	246	11	disorders	disorder	NNS
cord-034687-57n88v6t	246	12	and	and	CC
cord-034687-57n88v6t	246	13	biological	biological	JJ
cord-034687-57n88v6t	246	14	differences	difference	NNS
cord-034687-57n88v6t	246	15	in	in	IN
cord-034687-57n88v6t	246	16	the	the	DT
cord-034687-57n88v6t	246	17	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	246	18	system	system	NN
cord-034687-57n88v6t	246	19	compared	compare	VBN
cord-034687-57n88v6t	246	20	with	with	IN
cord-034687-57n88v6t	246	21	men	man	NNS
cord-034687-57n88v6t	246	22	.	.	.
cord-034687-57n88v6t	247	1	65	65	CD
cord-034687-57n88v6t	248	1	These	these	DT
cord-034687-57n88v6t	248	2	sex	sex	NN
cord-034687-57n88v6t	248	3	differences	difference	NNS
cord-034687-57n88v6t	248	4	have	have	VBP
cord-034687-57n88v6t	248	5	been	be	VBN
cord-034687-57n88v6t	248	6	studied	study	VBN
cord-034687-57n88v6t	248	7	in	in	IN
cord-034687-57n88v6t	248	8	animal	animal	NN
cord-034687-57n88v6t	248	9	models	model	NNS
cord-034687-57n88v6t	248	10	of	of	IN
cord-034687-57n88v6t	248	11	anxiety	anxiety	NN
cord-034687-57n88v6t	248	12	.	.	.
cord-034687-57n88v6t	249	1	CB	CB	NNP
cord-034687-57n88v6t	249	2	1	1	CD
cord-034687-57n88v6t	250	1	Rknockout	Rknockout	NNP
cord-034687-57n88v6t	250	2	males	male	NNS
cord-034687-57n88v6t	250	3	show	show	VBP
cord-034687-57n88v6t	250	4	a	a	DT
cord-034687-57n88v6t	250	5	basal	basal	NN
cord-034687-57n88v6t	250	6	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	250	7	behavior	behavior	NN
cord-034687-57n88v6t	250	8	that	that	WDT
cord-034687-57n88v6t	250	9	is	be	VBZ
cord-034687-57n88v6t	250	10	absent	absent	JJ
cord-034687-57n88v6t	250	11	in	in	IN
cord-034687-57n88v6t	250	12	females	female	NNS
cord-034687-57n88v6t	250	13	.	.	.
cord-034687-57n88v6t	251	1	66	66	CD
cord-034687-57n88v6t	252	1	Interestingly	interestingly	RB
cord-034687-57n88v6t	252	2	,	,	,
cord-034687-57n88v6t	252	3	both	both	DT
cord-034687-57n88v6t	252	4	sexes	sex	NNS
cord-034687-57n88v6t	252	5	show	show	VBP
cord-034687-57n88v6t	252	6	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	252	7	responses	response	NNS
cord-034687-57n88v6t	252	8	after	after	IN
cord-034687-57n88v6t	252	9	CB	CB	NNP
cord-034687-57n88v6t	252	10	1	1	CD
cord-034687-57n88v6t	252	11	R	r	NN
cord-034687-57n88v6t	252	12	blockade	blockade	NN
cord-034687-57n88v6t	252	13	,	,	,
cord-034687-57n88v6t	252	14	66	66	CD
cord-034687-57n88v6t	252	15	of	of	IN
cord-034687-57n88v6t	252	16	higher	high	JJR
cord-034687-57n88v6t	252	17	intensity	intensity	NN
cord-034687-57n88v6t	252	18	in	in	IN
cord-034687-57n88v6t	252	19	adolescent	adolescent	JJ
cord-034687-57n88v6t	252	20	females	female	NNS
cord-034687-57n88v6t	252	21	.	.	.
cord-034687-57n88v6t	253	1	67	67	CD
cord-034687-57n88v6t	254	1	However	however	RB
cord-034687-57n88v6t	254	2	,	,	,
cord-034687-57n88v6t	254	3	mice	mouse	NNS
cord-034687-57n88v6t	254	4	defective	defective	JJ
cord-034687-57n88v6t	254	5	in	in	IN
cord-034687-57n88v6t	254	6	the	the	DT
cord-034687-57n88v6t	254	7	2-AG	2-ag	CD
cord-034687-57n88v6t	254	8	-	-	HYPH
cord-034687-57n88v6t	254	9	synthesizing	synthesize	VBG
cord-034687-57n88v6t	254	10	enzyme	enzyme	NN
cord-034687-57n88v6t	254	11	DAGLα	DAGLα	NNS
cord-034687-57n88v6t	254	12	show	show	VBP
cord-034687-57n88v6t	254	13	no	no	DT
cord-034687-57n88v6t	254	14	gender	gender	NN
cord-034687-57n88v6t	254	15	differences	difference	NNS
cord-034687-57n88v6t	254	16	,	,	,
cord-034687-57n88v6t	254	17	except	except	IN
cord-034687-57n88v6t	254	18	for	for	IN
cord-034687-57n88v6t	254	19	a	a	DT
cord-034687-57n88v6t	254	20	maternal	maternal	JJ
cord-034687-57n88v6t	254	21	neglecting	neglect	VBG
cord-034687-57n88v6t	254	22	behavior	behavior	NN
cord-034687-57n88v6t	254	23	inherent	inherent	JJ
cord-034687-57n88v6t	254	24	to	to	IN
cord-034687-57n88v6t	254	25	the	the	DT
cord-034687-57n88v6t	254	26	female	female	JJ
cord-034687-57n88v6t	254	27	condition	condition	NN
cord-034687-57n88v6t	254	28	.	.	.
cord-034687-57n88v6t	255	1	17	17	CD
cord-034687-57n88v6t	255	2	Exposure	exposure	NN
cord-034687-57n88v6t	255	3	of	of	IN
cord-034687-57n88v6t	255	4	pregnant	pregnant	JJ
cord-034687-57n88v6t	255	5	females	female	NNS
cord-034687-57n88v6t	255	6	to	to	IN
cord-034687-57n88v6t	255	7	THC	thc	NN
cord-034687-57n88v6t	255	8	68	68	CD
cord-034687-57n88v6t	255	9	or	or	CC
cord-034687-57n88v6t	255	10	to	to	IN
cord-034687-57n88v6t	255	11	polyunsaturated	polyunsaturated	JJ
cord-034687-57n88v6t	255	12	fatty	fatty	JJ
cord-034687-57n88v6t	255	13	acids	acid	NNS
cord-034687-57n88v6t	255	14	required	require	VBN
cord-034687-57n88v6t	255	15	for	for	IN
cord-034687-57n88v6t	255	16	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	255	17	synthesis	synthesis	NN
cord-034687-57n88v6t	255	18	69	69	CD
cord-034687-57n88v6t	255	19	produces	produce	VBZ
cord-034687-57n88v6t	255	20	life	life	NN
cord-034687-57n88v6t	255	21	-	-	HYPH
cord-034687-57n88v6t	255	22	long	long	JJ
cord-034687-57n88v6t	255	23	changes	change	NNS
cord-034687-57n88v6t	255	24	on	on	IN
cord-034687-57n88v6t	255	25	the	the	DT
cord-034687-57n88v6t	255	26	offspring	offspring	NN
cord-034687-57n88v6t	255	27	,	,	,
cord-034687-57n88v6t	255	28	altering	alter	VBG
cord-034687-57n88v6t	255	29	the	the	DT
cord-034687-57n88v6t	255	30	distribution	distribution	NN
cord-034687-57n88v6t	255	31	and	and	CC
cord-034687-57n88v6t	255	32	activity	activity	NN
cord-034687-57n88v6t	255	33	of	of	IN
cord-034687-57n88v6t	255	34	neuronal	neuronal	JJ
cord-034687-57n88v6t	255	35	populations	population	NNS
cord-034687-57n88v6t	255	36	expressing	express	VBG
cord-034687-57n88v6t	255	37	CB	CB	NNP
cord-034687-57n88v6t	255	38	1	1	CD
cord-034687-57n88v6t	256	1	R.	R.	NNP
cord-034687-57n88v6t	256	2	Prenatal	Prenatal	NNP
cord-034687-57n88v6t	256	3	THC	thc	NN
cord-034687-57n88v6t	256	4	causes	cause	VBZ
cord-034687-57n88v6t	256	5	male	male	NN
cord-034687-57n88v6t	256	6	-	-	HYPH
cord-034687-57n88v6t	256	7	specific	specific	JJ
cord-034687-57n88v6t	256	8	effects	effect	NNS
cord-034687-57n88v6t	256	9	,	,	,
cord-034687-57n88v6t	256	10	including	include	VBG
cord-034687-57n88v6t	256	11	disrupted	disrupt	VBN
cord-034687-57n88v6t	256	12	long	long	JJ
cord-034687-57n88v6t	256	13	-	-	HYPH
cord-034687-57n88v6t	256	14	term	term	NN
cord-034687-57n88v6t	256	15	depression	depression	NN
cord-034687-57n88v6t	256	16	(	(	-LRB-
cord-034687-57n88v6t	256	17	LTD	LTD	NNP
cord-034687-57n88v6t	256	18	)	)	-RRB-
cord-034687-57n88v6t	256	19	and	and	CC
cord-034687-57n88v6t	256	20	heightened	heighten	VBD
cord-034687-57n88v6t	256	21	excitability	excitability	NN
cord-034687-57n88v6t	256	22	in	in	IN
cord-034687-57n88v6t	256	23	the	the	DT
cord-034687-57n88v6t	256	24	PFC	PFC	NNP
cord-034687-57n88v6t	256	25	,	,	,
cord-034687-57n88v6t	256	26	enhanced	enhanced	JJ
cord-034687-57n88v6t	256	27	anxiety	anxiety	NN
cord-034687-57n88v6t	256	28	,	,	,
cord-034687-57n88v6t	256	29	and	and	CC
cord-034687-57n88v6t	256	30	social	social	JJ
cord-034687-57n88v6t	256	31	distancing	distancing	NN
cord-034687-57n88v6t	256	32	.	.	.
cord-034687-57n88v6t	257	1	68	68	CD
cord-034687-57n88v6t	258	1	Although	although	IN
cord-034687-57n88v6t	258	2	the	the	DT
cord-034687-57n88v6t	258	3	female	female	JJ
cord-034687-57n88v6t	258	4	offspring	offspring	NN
cord-034687-57n88v6t	258	5	did	do	VBD
cord-034687-57n88v6t	258	6	not	not	RB
cord-034687-57n88v6t	258	7	show	show	VB
cord-034687-57n88v6t	258	8	overt	overt	JJ
cord-034687-57n88v6t	258	9	behavioral	behavioral	JJ
cord-034687-57n88v6t	258	10	changes	change	NNS
cord-034687-57n88v6t	258	11	and	and	CC
cord-034687-57n88v6t	258	12	their	-PRON-	PRP$
cord-034687-57n88v6t	258	13	PFC	PFC	NNP
cord-034687-57n88v6t	258	14	LTD	LTD	NNP
cord-034687-57n88v6t	258	15	was	be	VBD
cord-034687-57n88v6t	258	16	maintained	maintain	VBN
cord-034687-57n88v6t	258	17	,	,	,
cord-034687-57n88v6t	258	18	transcriptional	transcriptional	JJ
cord-034687-57n88v6t	258	19	modifications	modification	NNS
cord-034687-57n88v6t	258	20	and	and	CC
cord-034687-57n88v6t	258	21	a	a	DT
cord-034687-57n88v6t	258	22	switch	switch	NN
cord-034687-57n88v6t	258	23	from	from	IN
cord-034687-57n88v6t	258	24	CB	CB	NNP
cord-034687-57n88v6t	258	25	1	1	CD
cord-034687-57n88v6t	258	26	R	r	NN
cord-034687-57n88v6t	258	27	to	to	IN
cord-034687-57n88v6t	258	28	TRPV1-mediated	TRPV1-mediated	NNP
cord-034687-57n88v6t	258	29	LTD	LTD	NNP
cord-034687-57n88v6t	258	30	have	have	VBP
cord-034687-57n88v6t	258	31	been	be	VBN
cord-034687-57n88v6t	258	32	found	find	VBN
cord-034687-57n88v6t	258	33	,	,	,
cord-034687-57n88v6t	258	34	suggesting	suggest	VBG
cord-034687-57n88v6t	258	35	the	the	DT
cord-034687-57n88v6t	258	36	existence	existence	NN
cord-034687-57n88v6t	258	37	of	of	IN
cord-034687-57n88v6t	258	38	protective	protective	JJ
cord-034687-57n88v6t	258	39	mechanisms	mechanism	NNS
cord-034687-57n88v6t	258	40	or	or	CC
cord-034687-57n88v6t	258	41	latent	latent	JJ
cord-034687-57n88v6t	258	42	alterations	alteration	NNS
cord-034687-57n88v6t	258	43	in	in	IN
cord-034687-57n88v6t	258	44	females	female	NNS
cord-034687-57n88v6t	258	45	.	.	.
cord-034687-57n88v6t	259	1	Further	further	JJ
cord-034687-57n88v6t	259	2	studies	study	NNS
cord-034687-57n88v6t	259	3	will	will	MD
cord-034687-57n88v6t	259	4	be	be	VB
cord-034687-57n88v6t	259	5	needed	need	VBN
cord-034687-57n88v6t	259	6	to	to	TO
cord-034687-57n88v6t	259	7	understand	understand	VB
cord-034687-57n88v6t	259	8	the	the	DT
cord-034687-57n88v6t	259	9	long	long	RB
cord-034687-57n88v6t	259	10	-	-	HYPH
cord-034687-57n88v6t	259	11	lasting	last	VBG
cord-034687-57n88v6t	259	12	consequences	consequence	NNS
cord-034687-57n88v6t	259	13	of	of	IN
cord-034687-57n88v6t	259	14	THC	thc	NN
cord-034687-57n88v6t	259	15	exposure	exposure	NN
cord-034687-57n88v6t	259	16	on	on	IN
cord-034687-57n88v6t	259	17	the	the	DT
cord-034687-57n88v6t	259	18	developing	develop	VBG
cord-034687-57n88v6t	259	19	female	female	JJ
cord-034687-57n88v6t	259	20	brain	brain	NN
cord-034687-57n88v6t	259	21	.	.	.
cord-034687-57n88v6t	260	1	The	the	DT
cord-034687-57n88v6t	260	2	possible	possible	JJ
cord-034687-57n88v6t	260	3	impact	impact	NN
cord-034687-57n88v6t	260	4	of	of	IN
cord-034687-57n88v6t	260	5	periadolescent	periadolescent	NN
cord-034687-57n88v6t	260	6	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	260	7	exposure	exposure	NN
cord-034687-57n88v6t	260	8	on	on	IN
cord-034687-57n88v6t	260	9	anxiety	anxiety	NN
cord-034687-57n88v6t	260	10	levels	level	NNS
cord-034687-57n88v6t	260	11	during	during	IN
cord-034687-57n88v6t	260	12	adulthood	adulthood	NN
cord-034687-57n88v6t	260	13	has	have	VBZ
cord-034687-57n88v6t	260	14	been	be	VBN
cord-034687-57n88v6t	260	15	investigated	investigate	VBN
cord-034687-57n88v6t	260	16	.	.	.
cord-034687-57n88v6t	261	1	Reduced	reduced	JJ
cord-034687-57n88v6t	261	2	anxiety	anxiety	NN
cord-034687-57n88v6t	261	3	has	have	VBZ
cord-034687-57n88v6t	261	4	been	be	VBN
cord-034687-57n88v6t	261	5	revealed	reveal	VBN
cord-034687-57n88v6t	261	6	in	in	IN
cord-034687-57n88v6t	261	7	previously	previously	RB
cord-034687-57n88v6t	261	8	exposed	expose	VBN
cord-034687-57n88v6t	261	9	males	male	NNS
cord-034687-57n88v6t	261	10	,	,	,
cord-034687-57n88v6t	261	11	although	although	IN
cord-034687-57n88v6t	261	12	such	such	PDT
cord-034687-57n88v6t	261	13	an	an	DT
cord-034687-57n88v6t	261	14	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	261	15	effect	effect	NN
cord-034687-57n88v6t	261	16	is	be	VBZ
cord-034687-57n88v6t	261	17	inconsistently	inconsistently	RB
cord-034687-57n88v6t	261	18	reported	report	VBN
cord-034687-57n88v6t	261	19	in	in	IN
cord-034687-57n88v6t	261	20	adult	adult	NN
cord-034687-57n88v6t	261	21	females	female	NNS
cord-034687-57n88v6t	261	22	.	.	.
cord-034687-57n88v6t	262	1	70	70	CD
cord-034687-57n88v6t	262	2	THC	thc	NN
cord-034687-57n88v6t	262	3	exposure	exposure	NN
cord-034687-57n88v6t	262	4	or	or	CC
cord-034687-57n88v6t	262	5	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	262	6	disruption	disruption	NN
cord-034687-57n88v6t	262	7	of	of	IN
cord-034687-57n88v6t	262	8	the	the	DT
cord-034687-57n88v6t	262	9	endocannabinoid	endocannabinoid	JJ
cord-034687-57n88v6t	262	10	tone	tone	NN
cord-034687-57n88v6t	262	11	during	during	IN
cord-034687-57n88v6t	262	12	early	early	JJ
cord-034687-57n88v6t	262	13	adolescence	adolescence	NN
cord-034687-57n88v6t	262	14	also	also	RB
cord-034687-57n88v6t	262	15	provokes	provoke	VBZ
cord-034687-57n88v6t	262	16	decreased	decrease	VBN
cord-034687-57n88v6t	262	17	sociability	sociability	NN
cord-034687-57n88v6t	262	18	in	in	IN
cord-034687-57n88v6t	262	19	both	both	DT
cord-034687-57n88v6t	262	20	sexes	sex	NNS
cord-034687-57n88v6t	262	21	,	,	,
cord-034687-57n88v6t	262	22	occasionally	occasionally	RB
cord-034687-57n88v6t	262	23	without	without	IN
cord-034687-57n88v6t	262	24	evident	evident	JJ
cord-034687-57n88v6t	262	25	anxiety	anxiety	NN
cord-034687-57n88v6t	262	26	alterations	alteration	NNS
cord-034687-57n88v6t	262	27	,	,	,
cord-034687-57n88v6t	262	28	71,72	71,72	CD
cord-034687-57n88v6t	262	29	that	that	WDT
cord-034687-57n88v6t	262	30	may	may	MD
cord-034687-57n88v6t	262	31	not	not	RB
cord-034687-57n88v6t	262	32	persist	persist	VB
cord-034687-57n88v6t	262	33	in	in	IN
cord-034687-57n88v6t	262	34	the	the	DT
cord-034687-57n88v6t	262	35	adult	adult	NN
cord-034687-57n88v6t	262	36	age	age	NN
cord-034687-57n88v6t	262	37	.	.	.
cord-034687-57n88v6t	263	1	71	71	CD
cord-034687-57n88v6t	263	2	,	,	,
cord-034687-57n88v6t	263	3	73	73	CD
cord-034687-57n88v6t	264	1	However	however	RB
cord-034687-57n88v6t	264	2	,	,	,
cord-034687-57n88v6t	264	3	the	the	DT
cord-034687-57n88v6t	264	4	existence	existence	NN
cord-034687-57n88v6t	264	5	of	of	IN
cord-034687-57n88v6t	264	6	significant	significant	JJ
cord-034687-57n88v6t	264	7	modifications	modification	NNS
cord-034687-57n88v6t	264	8	during	during	IN
cord-034687-57n88v6t	264	9	a	a	DT
cord-034687-57n88v6t	264	10	critical	critical	JJ
cord-034687-57n88v6t	264	11	age	age	NN
cord-034687-57n88v6t	264	12	for	for	IN
cord-034687-57n88v6t	264	13	brain	brain	NN
cord-034687-57n88v6t	264	14	development	development	NN
cord-034687-57n88v6t	264	15	demands	demand	VBZ
cord-034687-57n88v6t	264	16	caution	caution	NN
cord-034687-57n88v6t	264	17	with	with	IN
cord-034687-57n88v6t	264	18	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	264	19	intake	intake	NN
cord-034687-57n88v6t	264	20	.	.	.
cord-034687-57n88v6t	265	1	Indeed	indeed	RB
cord-034687-57n88v6t	265	2	,	,	,
cord-034687-57n88v6t	265	3	fMRI	fMRI	NNP
cord-034687-57n88v6t	265	4	studies	study	NNS
cord-034687-57n88v6t	265	5	in	in	IN
cord-034687-57n88v6t	265	6	humans	human	NNS
cord-034687-57n88v6t	265	7	have	have	VBP
cord-034687-57n88v6t	265	8	described	describe	VBN
cord-034687-57n88v6t	265	9	long	long	RB
cord-034687-57n88v6t	265	10	-	-	HYPH
cord-034687-57n88v6t	265	11	lasting	last	VBG
cord-034687-57n88v6t	265	12	consequences	consequence	NNS
cord-034687-57n88v6t	265	13	of	of	IN
cord-034687-57n88v6t	265	14	THC	thc	NN
cord-034687-57n88v6t	265	15	exposure	exposure	NN
cord-034687-57n88v6t	265	16	,	,	,
cord-034687-57n88v6t	265	17	including	include	VBG
cord-034687-57n88v6t	265	18	increased	increase	VBN
cord-034687-57n88v6t	265	19	gray	gray	JJ
cord-034687-57n88v6t	265	20	-	-	HYPH
cord-034687-57n88v6t	265	21	matter	matter	NN
cord-034687-57n88v6t	265	22	volume	volume	NN
cord-034687-57n88v6t	265	23	of	of	IN
cord-034687-57n88v6t	265	24	brain	brain	NN
cord-034687-57n88v6t	265	25	temporal	temporal	JJ
cord-034687-57n88v6t	265	26	areas	area	NNS
cord-034687-57n88v6t	265	27	and	and	CC
cord-034687-57n88v6t	265	28	amygdala	amygdala	NN
cord-034687-57n88v6t	265	29	hypersensitivity	hypersensitivity	NN
cord-034687-57n88v6t	265	30	,	,	,
cord-034687-57n88v6t	265	31	associated	associate	VBN
cord-034687-57n88v6t	265	32	with	with	IN
cord-034687-57n88v6t	265	33	the	the	DT
cord-034687-57n88v6t	265	34	development	development	NN
cord-034687-57n88v6t	265	35	of	of	IN
cord-034687-57n88v6t	265	36	anxious	anxious	JJ
cord-034687-57n88v6t	265	37	symptomatology	symptomatology	NN
cord-034687-57n88v6t	265	38	.	.	.
cord-034687-57n88v6t	266	1	74	74	CD
cord-034687-57n88v6t	266	2	,	,	,
cord-034687-57n88v6t	266	3	75	75	CD
cord-034687-57n88v6t	267	1	The	the	DT
cord-034687-57n88v6t	267	2	effects	effect	NNS
cord-034687-57n88v6t	267	3	of	of	IN
cord-034687-57n88v6t	267	4	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	267	5	exposure	exposure	NN
cord-034687-57n88v6t	267	6	may	may	MD
cord-034687-57n88v6t	267	7	be	be	VB
cord-034687-57n88v6t	267	8	different	different	JJ
cord-034687-57n88v6t	267	9	in	in	IN
cord-034687-57n88v6t	267	10	individuals	individual	NNS
cord-034687-57n88v6t	267	11	who	who	WP
cord-034687-57n88v6t	267	12	suffered	suffer	VBD
cord-034687-57n88v6t	267	13	previous	previous	JJ
cord-034687-57n88v6t	267	14	threatening	threaten	VBG
cord-034687-57n88v6t	267	15	experiences	experience	NNS
cord-034687-57n88v6t	267	16	.	.	.
cord-034687-57n88v6t	268	1	Thus	thus	RB
cord-034687-57n88v6t	268	2	,	,	,
cord-034687-57n88v6t	268	3	rodents	rodent	NNS
cord-034687-57n88v6t	268	4	subjected	subject	VBN
cord-034687-57n88v6t	268	5	to	to	IN
cord-034687-57n88v6t	268	6	early	early	JJ
cord-034687-57n88v6t	268	7	life	life	NN
cord-034687-57n88v6t	268	8	stress	stress	NN
cord-034687-57n88v6t	268	9	show	show	NN
cord-034687-57n88v6t	268	10	reduced	reduce	VBN
cord-034687-57n88v6t	268	11	anxiety	anxiety	NN
cord-034687-57n88v6t	268	12	and	and	CC
cord-034687-57n88v6t	268	13	cognitive	cognitive	JJ
cord-034687-57n88v6t	268	14	and	and	CC
cord-034687-57n88v6t	268	15	social	social	JJ
cord-034687-57n88v6t	268	16	impairments	impairment	NNS
cord-034687-57n88v6t	268	17	after	after	IN
cord-034687-57n88v6t	268	18	CB	CB	NNP
cord-034687-57n88v6t	268	19	1	1	CD
cord-034687-57n88v6t	268	20	R	R	NNP
cord-034687-57n88v6t	268	21	agonist	agonist	NN
cord-034687-57n88v6t	268	22	administration	administration	NN
cord-034687-57n88v6t	268	23	during	during	IN
cord-034687-57n88v6t	268	24	late	late	JJ
cord-034687-57n88v6t	268	25	adolescence	adolescence	NN
cord-034687-57n88v6t	268	26	.	.	.
cord-034687-57n88v6t	269	1	These	these	DT
cord-034687-57n88v6t	269	2	effects	effect	NNS
cord-034687-57n88v6t	269	3	are	be	VBP
cord-034687-57n88v6t	269	4	associated	associate	VBN
cord-034687-57n88v6t	269	5	with	with	IN
cord-034687-57n88v6t	269	6	the	the	DT
cord-034687-57n88v6t	269	7	normalization	normalization	NN
cord-034687-57n88v6t	269	8	of	of	IN
cord-034687-57n88v6t	269	9	biochemical	biochemical	JJ
cord-034687-57n88v6t	269	10	alterations	alteration	NNS
cord-034687-57n88v6t	269	11	in	in	IN
cord-034687-57n88v6t	269	12	BLA	BLA	NNP
cord-034687-57n88v6t	269	13	,	,	,
cord-034687-57n88v6t	269	14	PFC	PFC	NNP
cord-034687-57n88v6t	269	15	,	,	,
cord-034687-57n88v6t	269	16	and	and	CC
cord-034687-57n88v6t	269	17	hippocampus	hippocampus	NN
cord-034687-57n88v6t	269	18	of	of	IN
cord-034687-57n88v6t	269	19	males	male	NNS
cord-034687-57n88v6t	269	20	and	and	CC
cord-034687-57n88v6t	269	21	females	female	NNS
cord-034687-57n88v6t	269	22	.	.	.
cord-034687-57n88v6t	270	1	65	65	CD
cord-034687-57n88v6t	271	1	Additional	additional	JJ
cord-034687-57n88v6t	271	2	studies	study	NNS
cord-034687-57n88v6t	271	3	will	will	MD
cord-034687-57n88v6t	271	4	be	be	VB
cord-034687-57n88v6t	271	5	necessary	necessary	JJ
cord-034687-57n88v6t	271	6	to	to	TO
cord-034687-57n88v6t	271	7	evaluate	evaluate	VB
cord-034687-57n88v6t	271	8	the	the	DT
cord-034687-57n88v6t	271	9	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	271	10	possibilities	possibility	NNS
cord-034687-57n88v6t	271	11	of	of	IN
cord-034687-57n88v6t	271	12	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	271	13	treatments	treatment	NNS
cord-034687-57n88v6t	271	14	under	under	IN
cord-034687-57n88v6t	271	15	these	these	DT
cord-034687-57n88v6t	271	16	particularly	particularly	RB
cord-034687-57n88v6t	271	17	sensitive	sensitive	JJ
cord-034687-57n88v6t	271	18	conditions	condition	NNS
cord-034687-57n88v6t	271	19	.	.	.
cord-034687-57n88v6t	272	1	Recent	recent	JJ
cord-034687-57n88v6t	272	2	studies	study	NNS
cord-034687-57n88v6t	272	3	have	have	VBP
cord-034687-57n88v6t	272	4	allowed	allow	VBN
cord-034687-57n88v6t	272	5	a	a	DT
cord-034687-57n88v6t	272	6	better	well	JJR
cord-034687-57n88v6t	272	7	understanding	understanding	NN
cord-034687-57n88v6t	272	8	of	of	IN
cord-034687-57n88v6t	272	9	the	the	DT
cord-034687-57n88v6t	272	10	crucial	crucial	JJ
cord-034687-57n88v6t	272	11	role	role	NN
cord-034687-57n88v6t	272	12	played	play	VBN
cord-034687-57n88v6t	272	13	by	by	IN
cord-034687-57n88v6t	272	14	the	the	DT
cord-034687-57n88v6t	272	15	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	272	16	system	system	NN
cord-034687-57n88v6t	272	17	in	in	IN
cord-034687-57n88v6t	272	18	fear	fear	NN
cord-034687-57n88v6t	272	19	,	,	,
cord-034687-57n88v6t	272	20	anxiety	anxiety	NN
cord-034687-57n88v6t	272	21	,	,	,
cord-034687-57n88v6t	272	22	and	and	CC
cord-034687-57n88v6t	272	23	stress	stress	NN
cord-034687-57n88v6t	272	24	.	.	.
cord-034687-57n88v6t	273	1	CB	CB	NNP
cord-034687-57n88v6t	273	2	1	1	CD
cord-034687-57n88v6t	273	3	R	r	NN
cord-034687-57n88v6t	273	4	located	locate	VBN
cord-034687-57n88v6t	273	5	in	in	IN
cord-034687-57n88v6t	273	6	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	273	7	and	and	CC
cord-034687-57n88v6t	273	8	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	273	9	terminals	terminal	NNS
cord-034687-57n88v6t	273	10	of	of	IN
cord-034687-57n88v6t	273	11	the	the	DT
cord-034687-57n88v6t	273	12	limbic	limbic	JJ
cord-034687-57n88v6t	273	13	system	system	NN
cord-034687-57n88v6t	273	14	modulate	modulate	VBP
cord-034687-57n88v6t	273	15	the	the	DT
cord-034687-57n88v6t	273	16	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	273	17	overexcitation	overexcitation	NN
cord-034687-57n88v6t	273	18	in	in	IN
cord-034687-57n88v6t	273	19	the	the	DT
cord-034687-57n88v6t	273	20	amygdala	amygdala	NN
cord-034687-57n88v6t	273	21	,	,	,
cord-034687-57n88v6t	273	22	leading	lead	VBG
cord-034687-57n88v6t	273	23	to	to	TO
cord-034687-57n88v6t	273	24	fear	fear	VB
cord-034687-57n88v6t	273	25	behavior	behavior	NN
cord-034687-57n88v6t	273	26	.	.	.
cord-034687-57n88v6t	274	1	The	the	DT
cord-034687-57n88v6t	274	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	274	3	system	system	NN
cord-034687-57n88v6t	274	4	protects	protect	VBZ
cord-034687-57n88v6t	274	5	against	against	IN
cord-034687-57n88v6t	274	6	this	this	DT
cord-034687-57n88v6t	274	7	overactivation	overactivation	NN
cord-034687-57n88v6t	274	8	by	by	IN
cord-034687-57n88v6t	274	9	downregulating	downregulate	VBG
cord-034687-57n88v6t	274	10	CB	CB	NNP
cord-034687-57n88v6t	274	11	1	1	CD
cord-034687-57n88v6t	274	12	R	r	NN
cord-034687-57n88v6t	274	13	in	in	IN
cord-034687-57n88v6t	274	14	GABAergic	gabaergic	NN
cord-034687-57n88v6t	274	15	terminals	terminal	NNS
cord-034687-57n88v6t	274	16	,	,	,
cord-034687-57n88v6t	274	17	and	and	CC
cord-034687-57n88v6t	274	18	CB	CB	NNP
cord-034687-57n88v6t	274	19	1	1	CD
cord-034687-57n88v6t	274	20	R	r	NN
cord-034687-57n88v6t	274	21	in	in	IN
cord-034687-57n88v6t	274	22	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	274	23	terminals	terminal	NNS
cord-034687-57n88v6t	274	24	also	also	RB
cord-034687-57n88v6t	274	25	play	play	VBP
cord-034687-57n88v6t	274	26	a	a	DT
cord-034687-57n88v6t	274	27	complementary	complementary	JJ
cord-034687-57n88v6t	274	28	role	role	NN
cord-034687-57n88v6t	274	29	to	to	TO
cord-034687-57n88v6t	274	30	promote	promote	VB
cord-034687-57n88v6t	274	31	fear	fear	NN
cord-034687-57n88v6t	274	32	extinction	extinction	NN
cord-034687-57n88v6t	274	33	.	.	.
cord-034687-57n88v6t	275	1	CB	CB	NNP
cord-034687-57n88v6t	275	2	1	1	CD
cord-034687-57n88v6t	275	3	R	r	NN
cord-034687-57n88v6t	275	4	located	locate	VBN
cord-034687-57n88v6t	275	5	in	in	IN
cord-034687-57n88v6t	275	6	the	the	DT
cord-034687-57n88v6t	275	7	HPA	HPA	NNP
cord-034687-57n88v6t	275	8	axis	axis	NN
cord-034687-57n88v6t	275	9	and	and	CC
cord-034687-57n88v6t	275	10	the	the	DT
cord-034687-57n88v6t	275	11	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	275	12	nervous	nervous	JJ
cord-034687-57n88v6t	275	13	system	system	NN
cord-034687-57n88v6t	275	14	are	be	VBP
cord-034687-57n88v6t	275	15	key	key	JJ
cord-034687-57n88v6t	275	16	components	component	NNS
cord-034687-57n88v6t	275	17	to	to	TO
cord-034687-57n88v6t	275	18	modulate	modulate	VB
cord-034687-57n88v6t	275	19	acute	acute	JJ
cord-034687-57n88v6t	275	20	stress	stress	NN
cord-034687-57n88v6t	275	21	.	.	.
cord-034687-57n88v6t	276	1	CB	CB	NNP
cord-034687-57n88v6t	276	2	1	1	CD
cord-034687-57n88v6t	276	3	R	r	NN
cord-034687-57n88v6t	276	4	activation	activation	NN
cord-034687-57n88v6t	276	5	limits	limit	VBZ
cord-034687-57n88v6t	276	6	HPA	HPA	NNP
cord-034687-57n88v6t	276	7	axis	axis	NN
cord-034687-57n88v6t	276	8	and	and	CC
cord-034687-57n88v6t	276	9	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	276	10	activation	activation	NN
cord-034687-57n88v6t	276	11	during	during	IN
cord-034687-57n88v6t	276	12	stress	stress	NN
cord-034687-57n88v6t	276	13	,	,	,
cord-034687-57n88v6t	276	14	whereas	whereas	IN
cord-034687-57n88v6t	276	15	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	276	16	induce	induce	VBP
cord-034687-57n88v6t	276	17	through	through	IN
cord-034687-57n88v6t	276	18	the	the	DT
cord-034687-57n88v6t	276	19	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	276	20	system	system	NN
cord-034687-57n88v6t	276	21	the	the	DT
cord-034687-57n88v6t	276	22	activation	activation	NN
cord-034687-57n88v6t	276	23	of	of	IN
cord-034687-57n88v6t	276	24	amygdala	amygdala	NN
cord-034687-57n88v6t	276	25	circuits	circuit	NNS
cord-034687-57n88v6t	276	26	to	to	TO
cord-034687-57n88v6t	276	27	promote	promote	VB
cord-034687-57n88v6t	276	28	stress	stress	NN
cord-034687-57n88v6t	276	29	perception	perception	NN
cord-034687-57n88v6t	276	30	.	.	.
cord-034687-57n88v6t	277	1	These	these	DT
cord-034687-57n88v6t	277	2	effects	effect	NNS
cord-034687-57n88v6t	277	3	seem	seem	VBP
cord-034687-57n88v6t	277	4	mediated	mediate	VBN
cord-034687-57n88v6t	277	5	by	by	IN
cord-034687-57n88v6t	277	6	an	an	DT
cord-034687-57n88v6t	277	7	enhancement	enhancement	NN
cord-034687-57n88v6t	277	8	of	of	IN
cord-034687-57n88v6t	277	9	2-AG	2-ag	CD
cord-034687-57n88v6t	277	10	levels	level	NNS
cord-034687-57n88v6t	277	11	and	and	CC
cord-034687-57n88v6t	277	12	a	a	DT
cord-034687-57n88v6t	277	13	decreased	decrease	VBN
cord-034687-57n88v6t	277	14	anandamide	anandamide	NN
cord-034687-57n88v6t	277	15	synthesis	synthesis	NN
cord-034687-57n88v6t	277	16	in	in	IN
cord-034687-57n88v6t	277	17	brain	brain	NN
cord-034687-57n88v6t	277	18	areas	area	NNS
cord-034687-57n88v6t	277	19	related	relate	VBN
cord-034687-57n88v6t	277	20	to	to	IN
cord-034687-57n88v6t	277	21	emotional	emotional	JJ
cord-034687-57n88v6t	277	22	and	and	CC
cord-034687-57n88v6t	277	23	cognitive	cognitive	JJ
cord-034687-57n88v6t	277	24	responses	response	NNS
cord-034687-57n88v6t	277	25	during	during	IN
cord-034687-57n88v6t	277	26	stress	stress	NN
cord-034687-57n88v6t	277	27	.	.	.
cord-034687-57n88v6t	278	1	In	in	IN
cord-034687-57n88v6t	278	2	contrast	contrast	NN
cord-034687-57n88v6t	278	3	,	,	,
cord-034687-57n88v6t	278	4	chronic	chronic	JJ
cord-034687-57n88v6t	278	5	stress	stress	NN
cord-034687-57n88v6t	278	6	exposure	exposure	NN
cord-034687-57n88v6t	278	7	leads	lead	VBZ
cord-034687-57n88v6t	278	8	to	to	IN
cord-034687-57n88v6t	278	9	maladaptive	maladaptive	JJ
cord-034687-57n88v6t	278	10	changes	change	NNS
cord-034687-57n88v6t	278	11	involving	involve	VBG
cord-034687-57n88v6t	278	12	the	the	DT
cord-034687-57n88v6t	278	13	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	278	14	system	system	NN
cord-034687-57n88v6t	278	15	that	that	WDT
cord-034687-57n88v6t	278	16	may	may	MD
cord-034687-57n88v6t	278	17	predispose	predispose	VB
cord-034687-57n88v6t	278	18	to	to	IN
cord-034687-57n88v6t	278	19	the	the	DT
cord-034687-57n88v6t	278	20	development	development	NN
cord-034687-57n88v6t	278	21	of	of	IN
cord-034687-57n88v6t	278	22	emotional	emotional	JJ
cord-034687-57n88v6t	278	23	disorders	disorder	NNS
cord-034687-57n88v6t	278	24	.	.	.
cord-034687-57n88v6t	279	1	On	on	IN
cord-034687-57n88v6t	279	2	the	the	DT
cord-034687-57n88v6t	279	3	other	other	JJ
cord-034687-57n88v6t	279	4	hand	hand	NN
cord-034687-57n88v6t	279	5	,	,	,
cord-034687-57n88v6t	279	6	CB	CB	NNP
cord-034687-57n88v6t	279	7	1	1	CD
cord-034687-57n88v6t	279	8	R	r	NN
cord-034687-57n88v6t	279	9	located	locate	VBN
cord-034687-57n88v6t	279	10	in	in	IN
cord-034687-57n88v6t	279	11	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	279	12	and	and	CC
cord-034687-57n88v6t	279	13	GABAergic	gabaergic	NN
cord-034687-57n88v6t	279	14	terminals	terminal	NNS
cord-034687-57n88v6t	279	15	seem	seem	VBP
cord-034687-57n88v6t	279	16	to	to	TO
cord-034687-57n88v6t	279	17	play	play	VB
cord-034687-57n88v6t	279	18	an	an	DT
cord-034687-57n88v6t	279	19	opposite	opposite	JJ
cord-034687-57n88v6t	279	20	role	role	NN
cord-034687-57n88v6t	279	21	in	in	IN
cord-034687-57n88v6t	279	22	anxiety	anxiety	NN
cord-034687-57n88v6t	279	23	control	control	NN
cord-034687-57n88v6t	279	24	.	.	.
cord-034687-57n88v6t	280	1	CB	CB	NNP
cord-034687-57n88v6t	280	2	1	1	CD
cord-034687-57n88v6t	280	3	Rs	r	NNS
cord-034687-57n88v6t	280	4	in	in	IN
cord-034687-57n88v6t	280	5	cortical	cortical	JJ
cord-034687-57n88v6t	280	6	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	280	7	terminals	terminal	NNS
cord-034687-57n88v6t	280	8	inhibit	inhibit	VBP
cord-034687-57n88v6t	280	9	glutamate	glutamate	NN
cord-034687-57n88v6t	280	10	release	release	NN
cord-034687-57n88v6t	280	11	,	,	,
cord-034687-57n88v6t	280	12	and	and	CC
cord-034687-57n88v6t	280	13	their	-PRON-	PRP$
cord-034687-57n88v6t	280	14	activation	activation	NN
cord-034687-57n88v6t	280	15	induces	induce	VBZ
cord-034687-57n88v6t	280	16	anxiolysis	anxiolysis	NN
cord-034687-57n88v6t	280	17	,	,	,
cord-034687-57n88v6t	280	18	whereas	whereas	IN
cord-034687-57n88v6t	280	19	CB	CB	NNP
cord-034687-57n88v6t	280	20	1	1	CD
cord-034687-57n88v6t	280	21	R	r	NN
cord-034687-57n88v6t	280	22	activation	activation	NN
cord-034687-57n88v6t	280	23	from	from	IN
cord-034687-57n88v6t	280	24	the	the	DT
cord-034687-57n88v6t	280	25	larger	large	JJR
cord-034687-57n88v6t	280	26	population	population	NN
cord-034687-57n88v6t	280	27	of	of	IN
cord-034687-57n88v6t	280	28	forebrain	forebrain	JJ
cord-034687-57n88v6t	280	29	GABAergic	GABAergic	NNP
cord-034687-57n88v6t	280	30	neurons	neuron	NNS
cord-034687-57n88v6t	280	31	restricts	restrict	VBZ
cord-034687-57n88v6t	280	32	the	the	DT
cord-034687-57n88v6t	280	33	inhibitory	inhibitory	JJ
cord-034687-57n88v6t	280	34	GABA	GABA	NNP
cord-034687-57n88v6t	280	35	tone	tone	NN
cord-034687-57n88v6t	280	36	and	and	CC
cord-034687-57n88v6t	280	37	mainly	mainly	RB
cord-034687-57n88v6t	280	38	facilitates	facilitate	VBZ
cord-034687-57n88v6t	280	39	anxiety	anxiety	NN
cord-034687-57n88v6t	280	40	.	.	.
cord-034687-57n88v6t	281	1	This	this	DT
cord-034687-57n88v6t	281	2	opposite	opposite	JJ
cord-034687-57n88v6t	281	3	role	role	NN
cord-034687-57n88v6t	281	4	of	of	IN
cord-034687-57n88v6t	281	5	different	different	JJ
cord-034687-57n88v6t	281	6	CB	CB	NNP
cord-034687-57n88v6t	281	7	1	1	CD
cord-034687-57n88v6t	281	8	R	r	NN
cord-034687-57n88v6t	281	9	leads	lead	VBZ
cord-034687-57n88v6t	281	10	to	to	IN
cord-034687-57n88v6t	281	11	complex	complex	JJ
cord-034687-57n88v6t	281	12	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	281	13	circuits	circuit	NNS
cord-034687-57n88v6t	281	14	to	to	TO
cord-034687-57n88v6t	281	15	regulate	regulate	VB
cord-034687-57n88v6t	281	16	anxiety	anxiety	NN
cord-034687-57n88v6t	281	17	,	,	,
cord-034687-57n88v6t	281	18	where	where	WRB
cord-034687-57n88v6t	281	19	increasing	increase	VBG
cord-034687-57n88v6t	281	20	the	the	DT
cord-034687-57n88v6t	281	21	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	281	22	activity	activity	NN
cord-034687-57n88v6t	281	23	is	be	VBZ
cord-034687-57n88v6t	281	24	mostly	mostly	RB
cord-034687-57n88v6t	281	25	related	relate	VBN
cord-034687-57n88v6t	281	26	with	with	IN
cord-034687-57n88v6t	281	27	anxiolysis	anxiolysis	NN
cord-034687-57n88v6t	281	28	,	,	,
cord-034687-57n88v6t	281	29	although	although	IN
cord-034687-57n88v6t	281	30	an	an	DT
cord-034687-57n88v6t	281	31	enhanced	enhanced	JJ
cord-034687-57n88v6t	281	32	anxiety	anxiety	NN
cord-034687-57n88v6t	281	33	is	be	VBZ
cord-034687-57n88v6t	281	34	also	also	RB
cord-034687-57n88v6t	281	35	mediated	mediate	VBN
cord-034687-57n88v6t	281	36	in	in	IN
cord-034687-57n88v6t	281	37	particular	particular	JJ
cord-034687-57n88v6t	281	38	circuits	circuit	NNS
cord-034687-57n88v6t	281	39	.	.	.
cord-034687-57n88v6t	282	1	Therefore	therefore	RB
cord-034687-57n88v6t	282	2	,	,	,
cord-034687-57n88v6t	282	3	the	the	DT
cord-034687-57n88v6t	282	4	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	282	5	system	system	NN
cord-034687-57n88v6t	282	6	represents	represent	VBZ
cord-034687-57n88v6t	282	7	an	an	DT
cord-034687-57n88v6t	282	8	excellent	excellent	JJ
cord-034687-57n88v6t	282	9	target	target	NN
cord-034687-57n88v6t	282	10	for	for	IN
cord-034687-57n88v6t	282	11	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	282	12	purposes	purpose	NNS
cord-034687-57n88v6t	282	13	in	in	IN
cord-034687-57n88v6t	282	14	emotional	emotional	JJ
cord-034687-57n88v6t	282	15	disorders	disorder	NNS
cord-034687-57n88v6t	282	16	,	,	,
cord-034687-57n88v6t	282	17	and	and	CC
cord-034687-57n88v6t	282	18	the	the	DT
cord-034687-57n88v6t	282	19	main	main	JJ
cord-034687-57n88v6t	282	20	medical	medical	JJ
cord-034687-57n88v6t	282	21	reason	reason	NN
cord-034687-57n88v6t	282	22	for	for	IN
cord-034687-57n88v6t	282	23	cannabis	cannabis	NN
cord-034687-57n88v6t	282	24	consumption	consumption	NN
cord-034687-57n88v6t	282	25	is	be	VBZ
cord-034687-57n88v6t	282	26	anxiety	anxiety	NN
cord-034687-57n88v6t	282	27	relief	relief	NN
cord-034687-57n88v6t	282	28	.	.	.
cord-034687-57n88v6t	283	1	As	as	IN
cord-034687-57n88v6t	283	2	expected	expect	VBN
cord-034687-57n88v6t	283	3	,	,	,
cord-034687-57n88v6t	283	4	considering	consider	VBG
cord-034687-57n88v6t	283	5	the	the	DT
cord-034687-57n88v6t	283	6	complexity	complexity	NN
cord-034687-57n88v6t	283	7	of	of	IN
cord-034687-57n88v6t	283	8	the	the	DT
cord-034687-57n88v6t	283	9	endocannabinoid	endocannabinoid	JJ
cord-034687-57n88v6t	283	10	role	role	NN
cord-034687-57n88v6t	283	11	in	in	IN
cord-034687-57n88v6t	283	12	anxiety	anxiety	NN
cord-034687-57n88v6t	283	13	,	,	,
cord-034687-57n88v6t	283	14	anxiogenic	anxiogenic	JJ
cord-034687-57n88v6t	283	15	responses	response	NNS
cord-034687-57n88v6t	283	16	are	be	VBP
cord-034687-57n88v6t	283	17	also	also	RB
cord-034687-57n88v6t	283	18	reported	report	VBN
cord-034687-57n88v6t	283	19	after	after	IN
cord-034687-57n88v6t	283	20	cannabis	cannabis	NN
cord-034687-57n88v6t	283	21	consumption	consumption	NN
cord-034687-57n88v6t	283	22	together	together	RB
cord-034687-57n88v6t	283	23	with	with	IN
cord-034687-57n88v6t	283	24	multiple	multiple	JJ
cord-034687-57n88v6t	283	25	side	side	NN
cord-034687-57n88v6t	283	26	effects	effect	NNS
cord-034687-57n88v6t	283	27	,	,	,
cord-034687-57n88v6t	283	28	which	which	WDT
cord-034687-57n88v6t	283	29	limits	limit	VBZ
cord-034687-57n88v6t	283	30	the	the	DT
cord-034687-57n88v6t	283	31	use	use	NN
cord-034687-57n88v6t	283	32	of	of	IN
cord-034687-57n88v6t	283	33	these	these	DT
cord-034687-57n88v6t	283	34	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	283	35	agonists	agonist	NNS
cord-034687-57n88v6t	283	36	for	for	IN
cord-034687-57n88v6t	283	37	treating	treat	VBG
cord-034687-57n88v6t	283	38	emotional	emotional	JJ
cord-034687-57n88v6t	283	39	disorders	disorder	NNS
cord-034687-57n88v6t	283	40	.	.	.
cord-034687-57n88v6t	284	1	Indeed	indeed	RB
cord-034687-57n88v6t	284	2	,	,	,
cord-034687-57n88v6t	284	3	although	although	IN
cord-034687-57n88v6t	284	4	self	self	NN
cord-034687-57n88v6t	284	5	-	-	HYPH
cord-034687-57n88v6t	284	6	reports	report	NNS
cord-034687-57n88v6t	284	7	of	of	IN
cord-034687-57n88v6t	284	8	cannabis	cannabis	NN
cord-034687-57n88v6t	284	9	users	user	NNS
cord-034687-57n88v6t	284	10	argue	argue	VBP
cord-034687-57n88v6t	284	11	acute	acute	JJ
cord-034687-57n88v6t	284	12	anxiolytic	anxiolytic	JJ
cord-034687-57n88v6t	284	13	consequences	consequence	NNS
cord-034687-57n88v6t	284	14	,	,	,
cord-034687-57n88v6t	284	15	the	the	DT
cord-034687-57n88v6t	284	16	effects	effect	NNS
cord-034687-57n88v6t	284	17	of	of	IN
cord-034687-57n88v6t	284	18	chronic	chronic	JJ
cord-034687-57n88v6t	284	19	consumption	consumption	NN
cord-034687-57n88v6t	284	20	are	be	VBP
cord-034687-57n88v6t	284	21	controversial	controversial	JJ
cord-034687-57n88v6t	284	22	and	and	CC
cord-034687-57n88v6t	284	23	systematic	systematic	JJ
cord-034687-57n88v6t	284	24	studies	study	NNS
cord-034687-57n88v6t	284	25	are	be	VBP
cord-034687-57n88v6t	284	26	still	still	RB
cord-034687-57n88v6t	284	27	missing	miss	VBG
cord-034687-57n88v6t	284	28	.	.	.
cord-034687-57n88v6t	285	1	76	76	CD
cord-034687-57n88v6t	286	1	Indeed	indeed	RB
cord-034687-57n88v6t	286	2	,	,	,
cord-034687-57n88v6t	286	3	chronic	chronic	JJ
cord-034687-57n88v6t	286	4	cannabis	cannabis	NN
cord-034687-57n88v6t	286	5	use	use	NN
cord-034687-57n88v6t	286	6	has	have	VBZ
cord-034687-57n88v6t	286	7	been	be	VBN
cord-034687-57n88v6t	286	8	reported	report	VBN
cord-034687-57n88v6t	286	9	to	to	TO
cord-034687-57n88v6t	286	10	produce	produce	VB
cord-034687-57n88v6t	286	11	opposite	opposite	JJ
cord-034687-57n88v6t	286	12	effects	effect	NNS
cord-034687-57n88v6t	286	13	in	in	IN
cord-034687-57n88v6t	286	14	some	some	DT
cord-034687-57n88v6t	286	15	individuals	individual	NNS
cord-034687-57n88v6t	286	16	,	,	,
cord-034687-57n88v6t	286	17	raising	raise	VBG
cord-034687-57n88v6t	286	18	the	the	DT
cord-034687-57n88v6t	286	19	risk	risk	NN
cord-034687-57n88v6t	286	20	for	for	IN
cord-034687-57n88v6t	286	21	the	the	DT
cord-034687-57n88v6t	286	22	onset	onset	NN
cord-034687-57n88v6t	286	23	of	of	IN
cord-034687-57n88v6t	286	24	anxiety	anxiety	NN
cord-034687-57n88v6t	286	25	disorders	disorder	NNS
cord-034687-57n88v6t	286	26	and	and	CC
cord-034687-57n88v6t	286	27	the	the	DT
cord-034687-57n88v6t	286	28	consequent	consequent	JJ
cord-034687-57n88v6t	286	29	enhancement	enhancement	NN
cord-034687-57n88v6t	286	30	in	in	IN
cord-034687-57n88v6t	286	31	the	the	DT
cord-034687-57n88v6t	286	32	severity	severity	NN
cord-034687-57n88v6t	286	33	of	of	IN
cord-034687-57n88v6t	286	34	negative	negative	JJ
cord-034687-57n88v6t	286	35	emotional	emotional	JJ
cord-034687-57n88v6t	286	36	symptoms	symptom	NNS
cord-034687-57n88v6t	286	37	.	.	.
cord-034687-57n88v6t	287	1	76	76	CD
cord-034687-57n88v6t	288	1	Furthermore	furthermore	RB
cord-034687-57n88v6t	288	2	,	,	,
cord-034687-57n88v6t	288	3	even	even	RB
cord-034687-57n88v6t	288	4	though	though	IN
cord-034687-57n88v6t	288	5	chronic	chronic	JJ
cord-034687-57n88v6t	288	6	cannabis	cannabis	NN
cord-034687-57n88v6t	288	7	use	use	NN
cord-034687-57n88v6t	288	8	does	do	VBZ
cord-034687-57n88v6t	288	9	not	not	RB
cord-034687-57n88v6t	288	10	produce	produce	VB
cord-034687-57n88v6t	288	11	clear	clear	JJ
cord-034687-57n88v6t	288	12	manifestations	manifestation	NNS
cord-034687-57n88v6t	288	13	of	of	IN
cord-034687-57n88v6t	288	14	physical	physical	JJ
cord-034687-57n88v6t	288	15	dependence	dependence	NN
cord-034687-57n88v6t	288	16	,	,	,
cord-034687-57n88v6t	288	17	abruptly	abruptly	RB
cord-034687-57n88v6t	288	18	stopping	stop	VBG
cord-034687-57n88v6t	288	19	its	-PRON-	PRP$
cord-034687-57n88v6t	288	20	use	use	NN
cord-034687-57n88v6t	288	21	can	can	MD
cord-034687-57n88v6t	288	22	trigger	trigger	VB
cord-034687-57n88v6t	288	23	withdrawal	withdrawal	NN
cord-034687-57n88v6t	288	24	symptoms	symptom	NNS
cord-034687-57n88v6t	288	25	,	,	,
cord-034687-57n88v6t	288	26	such	such	JJ
cord-034687-57n88v6t	288	27	as	as	IN
cord-034687-57n88v6t	288	28	sleep	sleep	NN
cord-034687-57n88v6t	288	29	disturbance	disturbance	NN
cord-034687-57n88v6t	288	30	,	,	,
cord-034687-57n88v6t	288	31	irritability	irritability	NN
cord-034687-57n88v6t	288	32	,	,	,
cord-034687-57n88v6t	288	33	and	and	CC
cord-034687-57n88v6t	288	34	anxiety	anxiety	NN
cord-034687-57n88v6t	288	35	.	.	.
cord-034687-57n88v6t	289	1	26	26	CD
cord-034687-57n88v6t	290	1	In	in	IN
cord-034687-57n88v6t	290	2	summary	summary	NN
cord-034687-57n88v6t	290	3	,	,	,
cord-034687-57n88v6t	290	4	additional	additional	JJ
cord-034687-57n88v6t	290	5	studies	study	NNS
cord-034687-57n88v6t	290	6	are	be	VBP
cord-034687-57n88v6t	290	7	needed	need	VBN
cord-034687-57n88v6t	290	8	to	to	TO
cord-034687-57n88v6t	290	9	determine	determine	VB
cord-034687-57n88v6t	290	10	the	the	DT
cord-034687-57n88v6t	290	11	possible	possible	JJ
cord-034687-57n88v6t	290	12	beneficial	beneficial	JJ
cord-034687-57n88v6t	290	13	effects	effect	NNS
cord-034687-57n88v6t	290	14	of	of	IN
cord-034687-57n88v6t	290	15	modulating	modulate	VBG
cord-034687-57n88v6t	290	16	the	the	DT
cord-034687-57n88v6t	290	17	activity	activity	NN
cord-034687-57n88v6t	290	18	of	of	IN
cord-034687-57n88v6t	290	19	the	the	DT
cord-034687-57n88v6t	290	20	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	290	21	system	system	NN
cord-034687-57n88v6t	290	22	for	for	IN
cord-034687-57n88v6t	290	23	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	290	24	purposes	purpose	NNS
cord-034687-57n88v6t	290	25	on	on	IN
cord-034687-57n88v6t	290	26	fear	fear	NN
cord-034687-57n88v6t	290	27	,	,	,
cord-034687-57n88v6t	290	28	anxiety	anxiety	NN
cord-034687-57n88v6t	290	29	,	,	,
cord-034687-57n88v6t	290	30	and	and	CC
cord-034687-57n88v6t	290	31	stress	stress	NN
cord-034687-57n88v6t	290	32	.	.	.
cord-034687-57n88v6t	291	1	77	77	CD
cord-034687-57n88v6t	292	1	In	in	IN
cord-034687-57n88v6t	292	2	spite	spite	NN
cord-034687-57n88v6t	292	3	of	of	IN
cord-034687-57n88v6t	292	4	the	the	DT
cord-034687-57n88v6t	292	5	prominent	prominent	JJ
cord-034687-57n88v6t	292	6	role	role	NN
cord-034687-57n88v6t	292	7	of	of	IN
cord-034687-57n88v6t	292	8	the	the	DT
cord-034687-57n88v6t	292	9	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	292	10	system	system	NN
cord-034687-57n88v6t	292	11	in	in	IN
cord-034687-57n88v6t	292	12	emotional	emotional	JJ
cord-034687-57n88v6t	292	13	disorders	disorder	NNS
cord-034687-57n88v6t	292	14	,	,	,
cord-034687-57n88v6t	292	15	we	-PRON-	PRP
cord-034687-57n88v6t	292	16	have	have	VBP
cord-034687-57n88v6t	292	17	not	not	RB
cord-034687-57n88v6t	292	18	yet	yet	RB
cord-034687-57n88v6t	292	19	taken	take	VBN
cord-034687-57n88v6t	292	20	advantage	advantage	NN
cord-034687-57n88v6t	292	21	of	of	IN
cord-034687-57n88v6t	292	22	the	the	DT
cord-034687-57n88v6t	292	23	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	292	24	implications	implication	NNS
cord-034687-57n88v6t	292	25	of	of	IN
cord-034687-57n88v6t	292	26	this	this	DT
cord-034687-57n88v6t	292	27	important	important	JJ
cord-034687-57n88v6t	292	28	pathophysiological	pathophysiological	JJ
cord-034687-57n88v6t	292	29	mechanism	mechanism	NN
cord-034687-57n88v6t	292	30	.	.	.
cord-034687-57n88v6t	293	1	The	the	DT
cord-034687-57n88v6t	293	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	293	3	system	system	NN
cord-034687-57n88v6t	293	4	is	be	VBZ
cord-034687-57n88v6t	293	5	very	very	RB
cord-034687-57n88v6t	293	6	widely	widely	RB
cord-034687-57n88v6t	293	7	expressed	express	VBN
cord-034687-57n88v6t	293	8	in	in	IN
cord-034687-57n88v6t	293	9	the	the	DT
cord-034687-57n88v6t	293	10	CNS	CNS	NNP
cord-034687-57n88v6t	293	11	and	and	CC
cord-034687-57n88v6t	293	12	a	a	DT
cord-034687-57n88v6t	293	13	systemic	systemic	JJ
cord-034687-57n88v6t	293	14	modulation	modulation	NN
cord-034687-57n88v6t	293	15	of	of	IN
cord-034687-57n88v6t	293	16	its	-PRON-	PRP$
cord-034687-57n88v6t	293	17	activity	activity	NN
cord-034687-57n88v6t	293	18	with	with	IN
cord-034687-57n88v6t	293	19	classical	classical	JJ
cord-034687-57n88v6t	293	20	ligands	ligand	NNS
cord-034687-57n88v6t	293	21	may	may	MD
cord-034687-57n88v6t	293	22	not	not	RB
cord-034687-57n88v6t	293	23	be	be	VB
cord-034687-57n88v6t	293	24	the	the	DT
cord-034687-57n88v6t	293	25	best	good	JJS
cord-034687-57n88v6t	293	26	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	293	27	approach	approach	NN
cord-034687-57n88v6t	293	28	due	due	IN
cord-034687-57n88v6t	293	29	to	to	IN
cord-034687-57n88v6t	293	30	the	the	DT
cord-034687-57n88v6t	293	31	large	large	JJ
cord-034687-57n88v6t	293	32	number	number	NN
cord-034687-57n88v6t	293	33	of	of	IN
cord-034687-57n88v6t	293	34	brain	brain	NN
cord-034687-57n88v6t	293	35	circuits	circuit	NNS
cord-034687-57n88v6t	293	36	that	that	WDT
cord-034687-57n88v6t	293	37	are	be	VBP
cord-034687-57n88v6t	293	38	affected	affect	VBN
cord-034687-57n88v6t	293	39	.	.	.
cord-034687-57n88v6t	294	1	Indeed	indeed	RB
cord-034687-57n88v6t	294	2	,	,	,
cord-034687-57n88v6t	294	3	important	important	JJ
cord-034687-57n88v6t	294	4	side	side	NN
cord-034687-57n88v6t	294	5	effects	effect	NNS
cord-034687-57n88v6t	294	6	have	have	VBP
cord-034687-57n88v6t	294	7	been	be	VBN
cord-034687-57n88v6t	294	8	reported	report	VBN
cord-034687-57n88v6t	294	9	when	when	WRB
cord-034687-57n88v6t	294	10	the	the	DT
cord-034687-57n88v6t	294	11	activity	activity	NN
cord-034687-57n88v6t	294	12	of	of	IN
cord-034687-57n88v6t	294	13	the	the	DT
cord-034687-57n88v6t	294	14	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	294	15	system	system	NN
cord-034687-57n88v6t	294	16	is	be	VBZ
cord-034687-57n88v6t	294	17	enhanced	enhance	VBN
cord-034687-57n88v6t	294	18	with	with	IN
cord-034687-57n88v6t	294	19	agonists	agonist	NNS
cord-034687-57n88v6t	294	20	,	,	,
cord-034687-57n88v6t	294	21	such	such	JJ
cord-034687-57n88v6t	294	22	as	as	IN
cord-034687-57n88v6t	294	23	THC	thc	NN
cord-034687-57n88v6t	294	24	,	,	,
cord-034687-57n88v6t	294	25	or	or	CC
cord-034687-57n88v6t	294	26	decreased	decrease	VBD
cord-034687-57n88v6t	294	27	with	with	IN
cord-034687-57n88v6t	294	28	inverse	inverse	JJ
cord-034687-57n88v6t	294	29	agonists	agonist	NNS
cord-034687-57n88v6t	294	30	,	,	,
cord-034687-57n88v6t	294	31	such	such	JJ
cord-034687-57n88v6t	294	32	as	as	IN
cord-034687-57n88v6t	294	33	rimonabant	rimonabant	NN
cord-034687-57n88v6t	294	34	.	.	.
cord-034687-57n88v6t	295	1	The	the	DT
cord-034687-57n88v6t	295	2	use	use	NN
cord-034687-57n88v6t	295	3	of	of	IN
cord-034687-57n88v6t	295	4	compounds	compound	NNS
cord-034687-57n88v6t	295	5	able	able	JJ
cord-034687-57n88v6t	295	6	to	to	TO
cord-034687-57n88v6t	295	7	modify	modify	VB
cord-034687-57n88v6t	295	8	the	the	DT
cord-034687-57n88v6t	295	9	synthesis	synthesis	NN
cord-034687-57n88v6t	295	10	/	/	SYM
cord-034687-57n88v6t	295	11	degradation	degradation	NN
cord-034687-57n88v6t	295	12	/	/	SYM
cord-034687-57n88v6t	295	13	reuptake	reuptake	NN
cord-034687-57n88v6t	295	14	of	of	IN
cord-034687-57n88v6t	295	15	endocannabinoids	endocannabinoid	NNS
cord-034687-57n88v6t	295	16	78	78	CD
cord-034687-57n88v6t	295	17	or	or	CC
cord-034687-57n88v6t	295	18	biased	bias	VBN
cord-034687-57n88v6t	295	19	modulators	modulator	NNS
cord-034687-57n88v6t	295	20	of	of	IN
cord-034687-57n88v6t	295	21	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	295	22	receptor	receptor	NN
cord-034687-57n88v6t	295	23	activity	activity	NN
cord-034687-57n88v6t	295	24	79	79	CD
cord-034687-57n88v6t	295	25	could	could	MD
cord-034687-57n88v6t	295	26	certainly	certainly	RB
cord-034687-57n88v6t	295	27	provide	provide	VB
cord-034687-57n88v6t	295	28	a	a	DT
cord-034687-57n88v6t	295	29	more	more	RBR
cord-034687-57n88v6t	295	30	appropriate	appropriate	JJ
cord-034687-57n88v6t	295	31	strategy	strategy	NN
cord-034687-57n88v6t	295	32	to	to	TO
cord-034687-57n88v6t	295	33	obtain	obtain	VB
cord-034687-57n88v6t	295	34	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	295	35	responses	response	NNS
cord-034687-57n88v6t	295	36	restricted	restrict	VBN
cord-034687-57n88v6t	295	37	to	to	IN
cord-034687-57n88v6t	295	38	a	a	DT
cord-034687-57n88v6t	295	39	beneficial	beneficial	JJ
cord-034687-57n88v6t	295	40	effect	effect	NN
cord-034687-57n88v6t	295	41	on	on	IN
cord-034687-57n88v6t	295	42	emotional	emotional	JJ
cord-034687-57n88v6t	295	43	disorders	disorder	NNS
cord-034687-57n88v6t	295	44	.	.	.
cord-034687-57n88v6t	296	1	Preclinical	preclinical	JJ
cord-034687-57n88v6t	296	2	data	datum	NNS
cord-034687-57n88v6t	296	3	and	and	CC
cord-034687-57n88v6t	296	4	preliminary	preliminary	JJ
cord-034687-57n88v6t	296	5	findings	finding	NNS
cord-034687-57n88v6t	296	6	in	in	IN
cord-034687-57n88v6t	296	7	humans	human	NNS
cord-034687-57n88v6t	296	8	obtained	obtain	VBN
cord-034687-57n88v6t	296	9	with	with	IN
cord-034687-57n88v6t	296	10	these	these	DT
cord-034687-57n88v6t	296	11	compounds	compound	NNS
cord-034687-57n88v6t	296	12	suggest	suggest	VBP
cord-034687-57n88v6t	296	13	that	that	IN
cord-034687-57n88v6t	296	14	indirect	indirect	JJ
cord-034687-57n88v6t	296	15	agonists	agonist	NNS
cord-034687-57n88v6t	296	16	and	and	CC
cord-034687-57n88v6t	296	17	biased	biased	JJ
cord-034687-57n88v6t	296	18	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	296	19	modulators	modulator	NNS
cord-034687-57n88v6t	296	20	could	could	MD
cord-034687-57n88v6t	296	21	represent	represent	VB
cord-034687-57n88v6t	296	22	novel	novel	JJ
cord-034687-57n88v6t	296	23	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	296	24	tools	tool	NNS
cord-034687-57n88v6t	296	25	to	to	TO
cord-034687-57n88v6t	296	26	obtain	obtain	VB
cord-034687-57n88v6t	296	27	therapeutic	therapeutic	JJ
cord-034687-57n88v6t	296	28	benefits	benefit	NNS
cord-034687-57n88v6t	296	29	by	by	IN
cord-034687-57n88v6t	296	30	modifying	modify	VBG
cord-034687-57n88v6t	296	31	the	the	DT
cord-034687-57n88v6t	296	32	activity	activity	NN
cord-034687-57n88v6t	296	33	of	of	IN
cord-034687-57n88v6t	296	34	the	the	DT
cord-034687-57n88v6t	296	35	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	296	36	system	system	NN
cord-034687-57n88v6t	296	37	.	.	.
cord-034687-57n88v6t	297	1	n	n	CC
cord-034687-57n88v6t	297	2	Epidemiology	epidemiology	NN
cord-034687-57n88v6t	297	3	of	of	IN
cord-034687-57n88v6t	297	4	anxiety	anxiety	NN
cord-034687-57n88v6t	297	5	disorders	disorder	NNS
cord-034687-57n88v6t	297	6	:	:	:
cord-034687-57n88v6t	297	7	from	from	IN
cord-034687-57n88v6t	297	8	surveys	survey	NNS
cord-034687-57n88v6t	297	9	to	to	IN
cord-034687-57n88v6t	297	10	nosology	nosology	NN
cord-034687-57n88v6t	297	11	and	and	CC
cord-034687-57n88v6t	297	12	back	back	JJ
cord-034687-57n88v6t	297	13	American	American	NNP
cord-034687-57n88v6t	297	14	Psychiatric	Psychiatric	NNP
cord-034687-57n88v6t	297	15	Association	Association	NNP
cord-034687-57n88v6t	297	16	.	.	.
cord-034687-57n88v6t	298	1	Diagnostic	diagnostic	JJ
cord-034687-57n88v6t	298	2	and	and	CC
cord-034687-57n88v6t	298	3	Statistical	Statistical	NNP
cord-034687-57n88v6t	298	4	Manual	Manual	NNP
cord-034687-57n88v6t	298	5	of	of	IN
cord-034687-57n88v6t	298	6	Mental	Mental	NNP
cord-034687-57n88v6t	298	7	Disorders	Disorders	NNPS
cord-034687-57n88v6t	298	8	Lost	lose	VBN
cord-034687-57n88v6t	298	9	in	in	IN
cord-034687-57n88v6t	298	10	translation	translation	NN
cord-034687-57n88v6t	298	11	:	:	:
cord-034687-57n88v6t	298	12	how	how	WRB
cord-034687-57n88v6t	298	13	to	to	TO
cord-034687-57n88v6t	298	14	upgrade	upgrade	VB
cord-034687-57n88v6t	298	15	fear	fear	NN
cord-034687-57n88v6t	298	16	memory	memory	NN
cord-034687-57n88v6t	298	17	research	research	NN
cord-034687-57n88v6t	298	18	Anatomical	anatomical	JJ
cord-034687-57n88v6t	298	19	distribution	distribution	NN
cord-034687-57n88v6t	298	20	of	of	IN
cord-034687-57n88v6t	298	21	receptors	receptor	NNS
cord-034687-57n88v6t	298	22	,	,	,
cord-034687-57n88v6t	298	23	ligands	ligand	NNS
cord-034687-57n88v6t	298	24	and	and	CC
cord-034687-57n88v6t	298	25	enzymes	enzyme	NNS
cord-034687-57n88v6t	298	26	in	in	IN
cord-034687-57n88v6t	298	27	the	the	DT
cord-034687-57n88v6t	298	28	brain	brain	NN
cord-034687-57n88v6t	298	29	and	and	CC
cord-034687-57n88v6t	298	30	in	in	IN
cord-034687-57n88v6t	298	31	the	the	DT
cord-034687-57n88v6t	298	32	spinal	spinal	JJ
cord-034687-57n88v6t	298	33	cord	cord	NN
cord-034687-57n88v6t	298	34	:	:	:
cord-034687-57n88v6t	298	35	circuitries	circuitry	NNS
cord-034687-57n88v6t	298	36	and	and	CC
cord-034687-57n88v6t	298	37	neurochemistry	neurochemistry	NN
cord-034687-57n88v6t	299	1	The	the	DT
cord-034687-57n88v6t	299	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	299	3	system	system	NN
cord-034687-57n88v6t	299	4	in	in	IN
cord-034687-57n88v6t	299	5	guarding	guard	VBG
cord-034687-57n88v6t	299	6	against	against	IN
cord-034687-57n88v6t	299	7	fear	fear	NN
cord-034687-57n88v6t	299	8	,	,	,
cord-034687-57n88v6t	299	9	anxiety	anxiety	NN
cord-034687-57n88v6t	299	10	and	and	CC
cord-034687-57n88v6t	299	11	stress	stress	NN
cord-034687-57n88v6t	300	1	The	the	DT
cord-034687-57n88v6t	300	2	neurocircuitry	neurocircuitry	NN
cord-034687-57n88v6t	300	3	of	of	IN
cord-034687-57n88v6t	300	4	fear	fear	NN
cord-034687-57n88v6t	300	5	,	,	,
cord-034687-57n88v6t	300	6	stress	stress	NN
cord-034687-57n88v6t	300	7	,	,	,
cord-034687-57n88v6t	300	8	and	and	CC
cord-034687-57n88v6t	300	9	anxiety	anxiety	NN
cord-034687-57n88v6t	300	10	disorders	disorder	NNS
cord-034687-57n88v6t	301	1	Stahl	Stahl	NNP
cord-034687-57n88v6t	301	2	's	's	POS
cord-034687-57n88v6t	301	3	Essential	Essential	NNP
cord-034687-57n88v6t	301	4	Psychopharmacology	Psychopharmacology	NNP
cord-034687-57n88v6t	301	5	Neuroscientific	Neuroscientific	NNP
cord-034687-57n88v6t	301	6	Basis	Basis	NNP
cord-034687-57n88v6t	301	7	and	and	CC
cord-034687-57n88v6t	301	8	Practical	Practical	NNP
cord-034687-57n88v6t	301	9	Application	Application	NNP
cord-034687-57n88v6t	301	10	4th	4th	NN
cord-034687-57n88v6t	301	11	Edition	Edition	NNP
cord-034687-57n88v6t	302	1	The	the	DT
cord-034687-57n88v6t	302	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	302	3	system	system	NN
cord-034687-57n88v6t	302	4	in	in	IN
cord-034687-57n88v6t	302	5	anxiety	anxiety	NN
cord-034687-57n88v6t	302	6	,	,	,
cord-034687-57n88v6t	302	7	fear	fear	VBP
cord-034687-57n88v6t	302	8	memory	memory	NN
cord-034687-57n88v6t	302	9	and	and	CC
cord-034687-57n88v6t	302	10	habituation	habituation	NN
cord-034687-57n88v6t	303	1	The	the	DT
cord-034687-57n88v6t	303	2	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	303	3	system	system	NN
cord-034687-57n88v6t	303	4	and	and	CC
cord-034687-57n88v6t	303	5	extinction	extinction	NN
cord-034687-57n88v6t	303	6	learning	learn	VBG
cord-034687-57n88v6t	303	7	Genetic	genetic	JJ
cord-034687-57n88v6t	303	8	dissection	dissection	NN
cord-034687-57n88v6t	303	9	of	of	IN
cord-034687-57n88v6t	303	10	the	the	DT
cord-034687-57n88v6t	303	11	role	role	NN
cord-034687-57n88v6t	303	12	of	of	IN
cord-034687-57n88v6t	303	13	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	303	14	type-1	type-1	NN
cord-034687-57n88v6t	303	15	receptors	receptor	NNS
cord-034687-57n88v6t	303	16	in	in	IN
cord-034687-57n88v6t	303	17	the	the	DT
cord-034687-57n88v6t	303	18	emotional	emotional	JJ
cord-034687-57n88v6t	303	19	consequences	consequence	NNS
cord-034687-57n88v6t	303	20	of	of	IN
cord-034687-57n88v6t	303	21	repeated	repeat	VBN
cord-034687-57n88v6t	303	22	social	social	JJ
cord-034687-57n88v6t	303	23	stress	stress	NN
cord-034687-57n88v6t	303	24	in	in	IN
cord-034687-57n88v6t	303	25	mice	mouse	NNS
cord-034687-57n88v6t	303	26	Bimodal	bimodal	JJ
cord-034687-57n88v6t	303	27	control	control	NN
cord-034687-57n88v6t	303	28	of	of	IN
cord-034687-57n88v6t	303	29	fear	fear	NN
cord-034687-57n88v6t	303	30	-	-	HYPH
cord-034687-57n88v6t	303	31	coping	cope	VBG
cord-034687-57n88v6t	303	32	strategies	strategy	NNS
cord-034687-57n88v6t	303	33	by	by	IN
cord-034687-57n88v6t	303	34	CB	CB	NNP
cord-034687-57n88v6t	303	35	1	1	CD
cord-034687-57n88v6t	303	36	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	303	37	receptors	receptor	NNS
cord-034687-57n88v6t	303	38	Dissecting	dissect	VBG
cord-034687-57n88v6t	303	39	the	the	DT
cord-034687-57n88v6t	303	40	cannabinergic	cannabinergic	NN
cord-034687-57n88v6t	303	41	control	control	NN
cord-034687-57n88v6t	303	42	of	of	IN
cord-034687-57n88v6t	303	43	behavior	behavior	NN
cord-034687-57n88v6t	303	44	:	:	:
cord-034687-57n88v6t	303	45	the	the	DT
cord-034687-57n88v6t	303	46	where	where	WRB
cord-034687-57n88v6t	303	47	matters	matter	NNS
cord-034687-57n88v6t	303	48	Bimodal	bimodal	JJ
cord-034687-57n88v6t	303	49	control	control	NN
cord-034687-57n88v6t	303	50	of	of	IN
cord-034687-57n88v6t	303	51	stimulated	stimulate	VBN
cord-034687-57n88v6t	303	52	food	food	NN
cord-034687-57n88v6t	303	53	intake	intake	NN
cord-034687-57n88v6t	303	54	by	by	IN
cord-034687-57n88v6t	303	55	the	the	DT
cord-034687-57n88v6t	303	56	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	303	57	system	system	NN
cord-034687-57n88v6t	303	58	Neuron	Neuron	NNP
cord-034687-57n88v6t	303	59	-	-	HYPH
cord-034687-57n88v6t	303	60	type	type	NN
cord-034687-57n88v6t	303	61	specific	specific	JJ
cord-034687-57n88v6t	303	62	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	303	63	-	-	HYPH
cord-034687-57n88v6t	303	64	mediated	mediate	VBN
cord-034687-57n88v6t	303	65	G	g	NN
cord-034687-57n88v6t	303	66	protein	protein	NN
cord-034687-57n88v6t	303	67	signalling	signal	VBG
cord-034687-57n88v6t	303	68	in	in	IN
cord-034687-57n88v6t	303	69	mouse	mouse	NN
cord-034687-57n88v6t	303	70	hippocampus	hippocampus	NN
cord-034687-57n88v6t	303	71	Short	short	JJ
cord-034687-57n88v6t	303	72	-	-	HYPH
cord-034687-57n88v6t	303	73	term	term	NN
cord-034687-57n88v6t	303	74	adaptation	adaptation	NN
cord-034687-57n88v6t	303	75	of	of	IN
cord-034687-57n88v6t	303	76	conditioned	condition	VBN
cord-034687-57n88v6t	303	77	fear	fear	NN
cord-034687-57n88v6t	303	78	responses	response	NNS
cord-034687-57n88v6t	303	79	through	through	IN
cord-034687-57n88v6t	303	80	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	303	81	signaling	signaling	NN
cord-034687-57n88v6t	303	82	in	in	IN
cord-034687-57n88v6t	303	83	the	the	DT
cord-034687-57n88v6t	303	84	central	central	JJ
cord-034687-57n88v6t	303	85	amygdala	amygdala	NN
cord-034687-57n88v6t	303	86	Anxiety	Anxiety	NNP
cord-034687-57n88v6t	303	87	,	,	,
cord-034687-57n88v6t	303	88	stress	stress	NN
cord-034687-57n88v6t	303	89	,	,	,
cord-034687-57n88v6t	303	90	and	and	CC
cord-034687-57n88v6t	303	91	fear	fear	VBP
cord-034687-57n88v6t	303	92	response	response	NN
cord-034687-57n88v6t	303	93	in	in	IN
cord-034687-57n88v6t	303	94	mice	mouse	NNS
cord-034687-57n88v6t	303	95	with	with	IN
cord-034687-57n88v6t	303	96	reduced	reduce	VBN
cord-034687-57n88v6t	303	97	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	303	98	levels	level	NNS
cord-034687-57n88v6t	304	1	Convergent	convergent	JJ
cord-034687-57n88v6t	304	2	translational	translational	JJ
cord-034687-57n88v6t	304	3	evidence	evidence	NN
cord-034687-57n88v6t	304	4	of	of	IN
cord-034687-57n88v6t	304	5	a	a	DT
cord-034687-57n88v6t	304	6	role	role	NN
cord-034687-57n88v6t	304	7	for	for	IN
cord-034687-57n88v6t	304	8	anandamide	anandamide	NN
cord-034687-57n88v6t	304	9	in	in	IN
cord-034687-57n88v6t	304	10	amygdala	amygdala	NN
cord-034687-57n88v6t	304	11	-	-	HYPH
cord-034687-57n88v6t	304	12	mediated	mediate	VBN
cord-034687-57n88v6t	304	13	fear	fear	NN
cord-034687-57n88v6t	304	14	extinction	extinction	NN
cord-034687-57n88v6t	304	15	,	,	,
cord-034687-57n88v6t	304	16	threat	threat	NN
cord-034687-57n88v6t	304	17	processing	processing	NN
cord-034687-57n88v6t	304	18	and	and	CC
cord-034687-57n88v6t	304	19	stress	stress	NN
cord-034687-57n88v6t	304	20	-	-	HYPH
cord-034687-57n88v6t	304	21	reactivity	reactivity	NN
cord-034687-57n88v6t	304	22	Δ	δ	NN
cord-034687-57n88v6t	304	23	9	9	CD
cord-034687-57n88v6t	304	24	-tetrahydrocannabinol	-tetrahydrocannabinol	CD
cord-034687-57n88v6t	304	25	and	and	CC
cord-034687-57n88v6t	304	26	ethanol	ethanol	NN
cord-034687-57n88v6t	304	27	:	:	:
cord-034687-57n88v6t	305	1	differential	differential	JJ
cord-034687-57n88v6t	305	2	effects	effect	NNS
cord-034687-57n88v6t	305	3	on	on	IN
cord-034687-57n88v6t	305	4	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	305	5	activity	activity	NN
cord-034687-57n88v6t	305	6	in	in	IN
cord-034687-57n88v6t	305	7	differing	differ	VBG
cord-034687-57n88v6t	305	8	environmental	environmental	JJ
cord-034687-57n88v6t	305	9	setting	set	VBG
cord-034687-57n88v6t	305	10	Activation	activation	NN
cord-034687-57n88v6t	305	11	of	of	IN
cord-034687-57n88v6t	305	12	the	the	DT
cord-034687-57n88v6t	305	13	sympathetic	sympathetic	JJ
cord-034687-57n88v6t	305	14	nervous	nervous	JJ
cord-034687-57n88v6t	305	15	system	system	NN
cord-034687-57n88v6t	305	16	mediates	mediate	VBZ
cord-034687-57n88v6t	305	17	hypophagic	hypophagic	NNP
cord-034687-57n88v6t	305	18	and	and	CC
cord-034687-57n88v6t	305	19	anxiety	anxiety	NN
cord-034687-57n88v6t	305	20	-	-	HYPH
cord-034687-57n88v6t	305	21	like	like	JJ
cord-034687-57n88v6t	305	22	effects	effect	NNS
cord-034687-57n88v6t	305	23	of	of	IN
cord-034687-57n88v6t	305	24	CB	CB	NNP
cord-034687-57n88v6t	305	25	1	1	CD
cord-034687-57n88v6t	305	26	receptor	receptor	NN
cord-034687-57n88v6t	305	27	blockade	blockade	NN
cord-034687-57n88v6t	306	1	The	the	DT
cord-034687-57n88v6t	306	2	endogenous	endogenous	JJ
cord-034687-57n88v6t	306	3	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	306	4	system	system	NN
cord-034687-57n88v6t	306	5	affects	affect	VBZ
cord-034687-57n88v6t	306	6	energy	energy	NN
cord-034687-57n88v6t	306	7	balance	balance	NN
cord-034687-57n88v6t	306	8	via	via	IN
cord-034687-57n88v6t	306	9	central	central	JJ
cord-034687-57n88v6t	306	10	orexigenic	orexigenic	NN
cord-034687-57n88v6t	306	11	drive	drive	NN
cord-034687-57n88v6t	306	12	and	and	CC
cord-034687-57n88v6t	306	13	peripheral	peripheral	JJ
cord-034687-57n88v6t	306	14	lipogenesis	lipogenesi	NNS
cord-034687-57n88v6t	306	15	Rapid	Rapid	NNP
cord-034687-57n88v6t	306	16	elevations	elevation	NNS
cord-034687-57n88v6t	306	17	in	in	IN
cord-034687-57n88v6t	306	18	limbic	limbic	JJ
cord-034687-57n88v6t	306	19	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	306	20	content	content	NN
cord-034687-57n88v6t	306	21	by	by	IN
cord-034687-57n88v6t	306	22	glucocorticoid	glucocorticoid	NN
cord-034687-57n88v6t	306	23	hormones	hormone	NNS
cord-034687-57n88v6t	306	24	in	in	IN
cord-034687-57n88v6t	306	25	vivo	vivo	NNP
cord-034687-57n88v6t	306	26	Limbic	Limbic	NNP
cord-034687-57n88v6t	306	27	system	system	NN
cord-034687-57n88v6t	306	28	mechanisms	mechanism	NNS
cord-034687-57n88v6t	306	29	of	of	IN
cord-034687-57n88v6t	306	30	stress	stress	NN
cord-034687-57n88v6t	306	31	regulation	regulation	NN
cord-034687-57n88v6t	306	32	:	:	:
cord-034687-57n88v6t	306	33	hypothalamo	hypothalamo	NN
cord-034687-57n88v6t	306	34	-	-	HYPH
cord-034687-57n88v6t	306	35	pituitary	pituitary	NN
cord-034687-57n88v6t	306	36	-	-	HYPH
cord-034687-57n88v6t	306	37	adrenocortical	adrenocortical	JJ
cord-034687-57n88v6t	306	38	axis	axis	NN
cord-034687-57n88v6t	307	1	Acute	acute	JJ
cord-034687-57n88v6t	307	2	stress	stress	NN
cord-034687-57n88v6t	307	3	suppresses	suppress	VBZ
cord-034687-57n88v6t	307	4	synaptic	synaptic	JJ
cord-034687-57n88v6t	307	5	inhibition	inhibition	NN
cord-034687-57n88v6t	307	6	and	and	CC
cord-034687-57n88v6t	307	7	increases	increase	VBZ
cord-034687-57n88v6t	307	8	anxiety	anxiety	NN
cord-034687-57n88v6t	307	9	via	via	IN
cord-034687-57n88v6t	307	10	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	307	11	release	release	NN
cord-034687-57n88v6t	307	12	in	in	IN
cord-034687-57n88v6t	307	13	the	the	DT
cord-034687-57n88v6t	307	14	basolateral	basolateral	JJ
cord-034687-57n88v6t	307	15	amygdala	amygdala	NN
cord-034687-57n88v6t	307	16	Cannabis	Cannabis	NNP
cord-034687-57n88v6t	307	17	addiction	addiction	NN
cord-034687-57n88v6t	307	18	and	and	CC
cord-034687-57n88v6t	307	19	the	the	DT
cord-034687-57n88v6t	307	20	brain	brain	NN
cord-034687-57n88v6t	307	21	:	:	:
cord-034687-57n88v6t	307	22	a	a	DT
cord-034687-57n88v6t	307	23	review	review	NN
cord-034687-57n88v6t	308	1	Concomitant	concomitant	JJ
cord-034687-57n88v6t	308	2	THC	thc	NN
cord-034687-57n88v6t	308	3	and	and	CC
cord-034687-57n88v6t	308	4	stress	stress	NN
cord-034687-57n88v6t	308	5	adolescent	adolescent	JJ
cord-034687-57n88v6t	308	6	exposure	exposure	NN
cord-034687-57n88v6t	308	7	induces	induce	VBZ
cord-034687-57n88v6t	308	8	impaired	impair	VBN
cord-034687-57n88v6t	308	9	fear	fear	NN
cord-034687-57n88v6t	308	10	extinction	extinction	NN
cord-034687-57n88v6t	308	11	and	and	CC
cord-034687-57n88v6t	308	12	related	relate	VBN
cord-034687-57n88v6t	308	13	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	308	14	changes	change	NNS
cord-034687-57n88v6t	308	15	in	in	IN
cord-034687-57n88v6t	308	16	adulthood	adulthood	NN
cord-034687-57n88v6t	308	17	Efficacy	efficacy	NN
cord-034687-57n88v6t	308	18	and	and	CC
cord-034687-57n88v6t	308	19	safety	safety	NN
cord-034687-57n88v6t	308	20	of	of	IN
cord-034687-57n88v6t	308	21	the	the	DT
cord-034687-57n88v6t	308	22	weightloss	weightloss	NNP
cord-034687-57n88v6t	308	23	drug	drug	NN
cord-034687-57n88v6t	308	24	rimonabant	rimonabant	NNP
cord-034687-57n88v6t	308	25	:	:	:
cord-034687-57n88v6t	308	26	a	a	DT
cord-034687-57n88v6t	308	27	meta	meta	JJ
cord-034687-57n88v6t	308	28	-	-	HYPH
cord-034687-57n88v6t	308	29	analysis	analysis	NN
cord-034687-57n88v6t	308	30	of	of	IN
cord-034687-57n88v6t	308	31	randomised	randomised	JJ
cord-034687-57n88v6t	308	32	trials	trial	NNS
cord-034687-57n88v6t	308	33	Corticotropin	Corticotropin	NNP
cord-034687-57n88v6t	308	34	-	-	HYPH
cord-034687-57n88v6t	308	35	releasing	release	VBG
cord-034687-57n88v6t	308	36	hormone	hormone	NN
cord-034687-57n88v6t	308	37	drives	drive	VBZ
cord-034687-57n88v6t	308	38	anandamide	anandamide	NN
cord-034687-57n88v6t	308	39	hydrolysis	hydrolysis	NN
cord-034687-57n88v6t	308	40	in	in	IN
cord-034687-57n88v6t	308	41	the	the	DT
cord-034687-57n88v6t	308	42	amygdala	amygdala	NN
cord-034687-57n88v6t	308	43	to	to	TO
cord-034687-57n88v6t	308	44	promote	promote	VB
cord-034687-57n88v6t	308	45	anxiety	anxiety	NN
cord-034687-57n88v6t	308	46	Role	role	NN
cord-034687-57n88v6t	308	47	of	of	IN
cord-034687-57n88v6t	308	48	the	the	DT
cord-034687-57n88v6t	308	49	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	308	50	system	system	NN
cord-034687-57n88v6t	308	51	in	in	IN
cord-034687-57n88v6t	308	52	the	the	DT
cord-034687-57n88v6t	308	53	dorsal	dorsal	JJ
cord-034687-57n88v6t	308	54	hippocampus	hippocampus	NN
cord-034687-57n88v6t	308	55	in	in	IN
cord-034687-57n88v6t	308	56	the	the	DT
cord-034687-57n88v6t	308	57	cardiovascular	cardiovascular	JJ
cord-034687-57n88v6t	308	58	changes	change	NNS
cord-034687-57n88v6t	308	59	and	and	CC
cord-034687-57n88v6t	308	60	delayed	delay	VBN
cord-034687-57n88v6t	308	61	anxiety	anxiety	NN
cord-034687-57n88v6t	308	62	-	-	HYPH
cord-034687-57n88v6t	308	63	like	like	JJ
cord-034687-57n88v6t	308	64	effect	effect	NN
cord-034687-57n88v6t	308	65	induced	induce	VBN
cord-034687-57n88v6t	308	66	by	by	IN
cord-034687-57n88v6t	308	67	acute	acute	JJ
cord-034687-57n88v6t	308	68	restraint	restraint	NN
cord-034687-57n88v6t	308	69	stress	stress	NN
cord-034687-57n88v6t	308	70	in	in	IN
cord-034687-57n88v6t	308	71	rats	rat	NNS
cord-034687-57n88v6t	308	72	Recruitment	Recruitment	NNP
cord-034687-57n88v6t	308	73	of	of	IN
cord-034687-57n88v6t	308	74	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	308	75	cortical	cortical	JJ
cord-034687-57n88v6t	308	76	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	308	77	signaling	signal	VBG
cord-034687-57n88v6t	308	78	by	by	IN
cord-034687-57n88v6t	308	79	glucocorticoids	glucocorticoid	NNS
cord-034687-57n88v6t	308	80	contributes	contribute	VBZ
cord-034687-57n88v6t	308	81	to	to	IN
cord-034687-57n88v6t	308	82	termination	termination	NN
cord-034687-57n88v6t	308	83	of	of	IN
cord-034687-57n88v6t	308	84	the	the	DT
cord-034687-57n88v6t	308	85	stress	stress	NN
cord-034687-57n88v6t	308	86	response	response	NN
cord-034687-57n88v6t	309	1	Neurobiological	neurobiological	JJ
cord-034687-57n88v6t	309	2	interactions	interaction	NNS
cord-034687-57n88v6t	309	3	between	between	IN
cord-034687-57n88v6t	309	4	stress	stress	NN
cord-034687-57n88v6t	309	5	and	and	CC
cord-034687-57n88v6t	309	6	the	the	DT
cord-034687-57n88v6t	309	7	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	309	8	system	system	NN
cord-034687-57n88v6t	309	9	Brain	Brain	NNP
cord-034687-57n88v6t	309	10	on	on	IN
cord-034687-57n88v6t	309	11	stress	stress	NN
cord-034687-57n88v6t	309	12	:	:	:
cord-034687-57n88v6t	309	13	how	how	WRB
cord-034687-57n88v6t	309	14	the	the	DT
cord-034687-57n88v6t	309	15	social	social	JJ
cord-034687-57n88v6t	309	16	environment	environment	NN
cord-034687-57n88v6t	309	17	gets	get	VBZ
cord-034687-57n88v6t	309	18	under	under	IN
cord-034687-57n88v6t	309	19	the	the	DT
cord-034687-57n88v6t	309	20	skin	skin	NN
cord-034687-57n88v6t	309	21	Endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	309	22	system	system	NN
cord-034687-57n88v6t	309	23	,	,	,
cord-034687-57n88v6t	309	24	stress	stress	NN
cord-034687-57n88v6t	309	25	and	and	CC
cord-034687-57n88v6t	309	26	HPA	HPA	NNP
cord-034687-57n88v6t	309	27	axis	axis	NN
cord-034687-57n88v6t	310	1	Constitutive	constitutive	JJ
cord-034687-57n88v6t	310	2	increases	increase	NNS
cord-034687-57n88v6t	310	3	in	in	IN
cord-034687-57n88v6t	310	4	amygdalar	amygdalar	NNP
cord-034687-57n88v6t	310	5	corticotropin	corticotropin	NNP
cord-034687-57n88v6t	310	6	-	-	HYPH
cord-034687-57n88v6t	310	7	releasing	release	VBG
cord-034687-57n88v6t	310	8	factor	factor	NN
cord-034687-57n88v6t	310	9	and	and	CC
cord-034687-57n88v6t	311	1	fatty	fatty	JJ
cord-034687-57n88v6t	311	2	acid	acid	NN
cord-034687-57n88v6t	311	3	amide	amide	NN
cord-034687-57n88v6t	311	4	hydrolase	hydrolase	NN
cord-034687-57n88v6t	311	5	drive	drive	VBP
cord-034687-57n88v6t	311	6	an	an	DT
cord-034687-57n88v6t	311	7	anxious	anxious	JJ
cord-034687-57n88v6t	311	8	phenotype	phenotype	NN
cord-034687-57n88v6t	312	1	Fatty	fatty	JJ
cord-034687-57n88v6t	312	2	acid	acid	NN
cord-034687-57n88v6t	312	3	amide	amide	NN
cord-034687-57n88v6t	312	4	hydrolase	hydrolase	NN
cord-034687-57n88v6t	312	5	inhibitors	inhibitor	NNS
cord-034687-57n88v6t	312	6	produce	produce	VBP
cord-034687-57n88v6t	312	7	rapid	rapid	JJ
cord-034687-57n88v6t	312	8	anti	anti	JJ
cord-034687-57n88v6t	312	9	-	-	JJ
cord-034687-57n88v6t	312	10	anxiety	anxiety	JJ
cord-034687-57n88v6t	312	11	responses	response	NNS
cord-034687-57n88v6t	312	12	through	through	IN
cord-034687-57n88v6t	312	13	amygdala	amygdala	JJ
cord-034687-57n88v6t	312	14	long	long	JJ
cord-034687-57n88v6t	312	15	-	-	HYPH
cord-034687-57n88v6t	312	16	term	term	NN
cord-034687-57n88v6t	312	17	depression	depression	NN
cord-034687-57n88v6t	312	18	in	in	IN
cord-034687-57n88v6t	312	19	male	male	JJ
cord-034687-57n88v6t	312	20	rodents	rodent	NNS
cord-034687-57n88v6t	312	21	Stress	stress	NN
cord-034687-57n88v6t	312	22	-	-	HYPH
cord-034687-57n88v6t	312	23	induced	induce	VBN
cord-034687-57n88v6t	312	24	modulation	modulation	NN
cord-034687-57n88v6t	312	25	of	of	IN
cord-034687-57n88v6t	312	26	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	312	27	signaling	signaling	NN
cord-034687-57n88v6t	312	28	leads	lead	NNS
cord-034687-57n88v6t	312	29	to	to	IN
cord-034687-57n88v6t	312	30	delayed	delay	VBN
cord-034687-57n88v6t	312	31	strengthening	strengthening	NN
cord-034687-57n88v6t	312	32	of	of	IN
cord-034687-57n88v6t	312	33	synaptic	synaptic	JJ
cord-034687-57n88v6t	312	34	connectivity	connectivity	NN
cord-034687-57n88v6t	312	35	in	in	IN
cord-034687-57n88v6t	312	36	the	the	DT
cord-034687-57n88v6t	312	37	amygdala	amygdala	NN
cord-034687-57n88v6t	312	38	Chattarji	Chattarji	NNP
cord-034687-57n88v6t	312	39	S.	S.	NNP
cord-034687-57n88v6t	312	40	Stress	Stress	NNP
cord-034687-57n88v6t	312	41	duration	duration	NN
cord-034687-57n88v6t	312	42	modulates	modulate	VBZ
cord-034687-57n88v6t	312	43	the	the	DT
cord-034687-57n88v6t	312	44	spatiotemporal	spatiotemporal	JJ
cord-034687-57n88v6t	312	45	patterns	pattern	NNS
cord-034687-57n88v6t	312	46	of	of	IN
cord-034687-57n88v6t	312	47	spine	spine	NN
cord-034687-57n88v6t	312	48	formation	formation	NN
cord-034687-57n88v6t	312	49	in	in	IN
cord-034687-57n88v6t	312	50	the	the	DT
cord-034687-57n88v6t	312	51	basolateral	basolateral	JJ
cord-034687-57n88v6t	312	52	amygdala	amygdala	NN
cord-034687-57n88v6t	312	53	Deficiency	deficiency	NN
cord-034687-57n88v6t	312	54	in	in	IN
cord-034687-57n88v6t	312	55	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	312	56	signaling	signaling	NN
cord-034687-57n88v6t	312	57	in	in	IN
cord-034687-57n88v6t	312	58	the	the	DT
cord-034687-57n88v6t	312	59	nucleus	nucleus	NN
cord-034687-57n88v6t	312	60	accumbens	accumbens	RB
cord-034687-57n88v6t	312	61	induced	induce	VBN
cord-034687-57n88v6t	312	62	by	by	IN
cord-034687-57n88v6t	312	63	chronic	chronic	JJ
cord-034687-57n88v6t	312	64	unpredictable	unpredictable	JJ
cord-034687-57n88v6t	312	65	stress	stress	NN
cord-034687-57n88v6t	312	66	Endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	312	67	signaling	signaling	NN
cord-034687-57n88v6t	312	68	as	as	IN
cord-034687-57n88v6t	312	69	an	an	DT
cord-034687-57n88v6t	312	70	intrinsic	intrinsic	JJ
cord-034687-57n88v6t	312	71	component	component	NN
cord-034687-57n88v6t	312	72	of	of	IN
cord-034687-57n88v6t	312	73	the	the	DT
cord-034687-57n88v6t	312	74	circuits	circuit	NNS
cord-034687-57n88v6t	312	75	mediating	mediate	VBG
cord-034687-57n88v6t	312	76	adaptive	adaptive	JJ
cord-034687-57n88v6t	312	77	responses	response	NNS
cord-034687-57n88v6t	312	78	to	to	IN
cord-034687-57n88v6t	312	79	repeated	repeat	VBN
cord-034687-57n88v6t	312	80	stress	stress	NN
cord-034687-57n88v6t	312	81	exposure	exposure	NN
cord-034687-57n88v6t	312	82	in	in	IN
cord-034687-57n88v6t	312	83	adult	adult	NN
cord-034687-57n88v6t	312	84	male	male	NN
cord-034687-57n88v6t	312	85	Sprague	Sprague	NNP
cord-034687-57n88v6t	312	86	Dawley	Dawley	NNP
cord-034687-57n88v6t	312	87	rats	rat	NNS
cord-034687-57n88v6t	312	88	Endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	312	89	system	system	NN
cord-034687-57n88v6t	312	90	and	and	CC
cord-034687-57n88v6t	312	91	adult	adult	NN
cord-034687-57n88v6t	312	92	neurogenesis	neurogenesis	NN
cord-034687-57n88v6t	312	93	:	:	:
cord-034687-57n88v6t	312	94	a	a	DT
cord-034687-57n88v6t	312	95	focused	focused	JJ
cord-034687-57n88v6t	312	96	review	review	NN
cord-034687-57n88v6t	313	1	Endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	313	2	signaling	signal	VBG
cord-034687-57n88v6t	313	3	collapse	collapse	NN
cord-034687-57n88v6t	313	4	mediates	mediate	VBZ
cord-034687-57n88v6t	313	5	stress	stress	NN
cord-034687-57n88v6t	313	6	-	-	HYPH
cord-034687-57n88v6t	313	7	induced	induce	VBN
cord-034687-57n88v6t	313	8	amygdalo	amygdalo	NNS
cord-034687-57n88v6t	313	9	-	-	HYPH
cord-034687-57n88v6t	313	10	cortical	cortical	JJ
cord-034687-57n88v6t	313	11	strengthening	strengthening	NN
cord-034687-57n88v6t	313	12	How	how	WRB
cord-034687-57n88v6t	313	13	I	-PRON-	PRP
cord-034687-57n88v6t	313	14	faced	face	VBD
cord-034687-57n88v6t	313	15	my	-PRON-	PRP$
cord-034687-57n88v6t	313	16	coronavirus	coronavirus	NN
cord-034687-57n88v6t	313	17	anxiety	anxiety	NN
cord-034687-57n88v6t	313	18	Using	use	VBG
cord-034687-57n88v6t	313	19	neuroscience	neuroscience	NN
cord-034687-57n88v6t	313	20	to	to	TO
cord-034687-57n88v6t	313	21	help	help	VB
cord-034687-57n88v6t	313	22	The	the	DT
cord-034687-57n88v6t	313	23	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	313	24	system	system	NN
cord-034687-57n88v6t	313	25	in	in	IN
cord-034687-57n88v6t	313	26	fear	fear	NN
cord-034687-57n88v6t	313	27	,	,	,
cord-034687-57n88v6t	313	28	anxiety	anxiety	NN
cord-034687-57n88v6t	313	29	,	,	,
cord-034687-57n88v6t	313	30	and	and	CC
cord-034687-57n88v6t	313	31	stress	stress	NN
cord-034687-57n88v6t	314	1	-Maldonado	-maldonado	NN
cord-034687-57n88v6t	315	1	et	et	NNP
cord-034687-57n88v6t	315	2	al	al	NNP
cord-034687-57n88v6t	315	3	understand	understand	VB
cord-034687-57n88v6t	315	4	fear	fear	NN
cord-034687-57n88v6t	315	5	and	and	CC
cord-034687-57n88v6t	315	6	anxiety	anxiety	NN
cord-034687-57n88v6t	315	7	:	:	:
cord-034687-57n88v6t	315	8	a	a	DT
cord-034687-57n88v6t	315	9	two	two	CD
cord-034687-57n88v6t	315	10	-	-	HYPH
cord-034687-57n88v6t	315	11	system	system	NN
cord-034687-57n88v6t	315	12	framework	framework	NN
cord-034687-57n88v6t	315	13	Uncertainty	uncertainty	NN
cord-034687-57n88v6t	315	14	and	and	CC
cord-034687-57n88v6t	315	15	anticipation	anticipation	NN
cord-034687-57n88v6t	315	16	in	in	IN
cord-034687-57n88v6t	315	17	anxiety	anxiety	NN
cord-034687-57n88v6t	315	18	:	:	:
cord-034687-57n88v6t	315	19	an	an	DT
cord-034687-57n88v6t	315	20	integrated	integrate	VBN
cord-034687-57n88v6t	315	21	neurobiological	neurobiological	JJ
cord-034687-57n88v6t	315	22	and	and	CC
cord-034687-57n88v6t	315	23	psychological	psychological	JJ
cord-034687-57n88v6t	315	24	perspective	perspective	NN
cord-034687-57n88v6t	316	1	The	the	DT
cord-034687-57n88v6t	316	2	role	role	NN
cord-034687-57n88v6t	316	3	of	of	IN
cord-034687-57n88v6t	316	4	cannabis	cannabis	NN
cord-034687-57n88v6t	316	5	in	in	IN
cord-034687-57n88v6t	316	6	treating	treat	VBG
cord-034687-57n88v6t	316	7	anxiety	anxiety	NN
cord-034687-57n88v6t	316	8	Adverse	adverse	JJ
cord-034687-57n88v6t	316	9	effects	effect	NNS
cord-034687-57n88v6t	316	10	of	of	IN
cord-034687-57n88v6t	316	11	cannabis	cannabis	NN
cord-034687-57n88v6t	316	12	Biphasic	Biphasic	NNP
cord-034687-57n88v6t	316	13	effects	effect	NNS
cord-034687-57n88v6t	316	14	of	of	IN
cord-034687-57n88v6t	316	15	cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	316	16	in	in	IN
cord-034687-57n88v6t	316	17	anxiety	anxiety	NN
cord-034687-57n88v6t	316	18	responses	response	NNS
cord-034687-57n88v6t	316	19	:	:	:
cord-034687-57n88v6t	316	20	CB1	CB1	NNP
cord-034687-57n88v6t	316	21	and	and	CC
cord-034687-57n88v6t	316	22	GABA	GABA	NNP
cord-034687-57n88v6t	316	23	B	B	NNP
cord-034687-57n88v6t	316	24	receptors	receptor	NNS
cord-034687-57n88v6t	316	25	in	in	IN
cord-034687-57n88v6t	316	26	the	the	DT
cord-034687-57n88v6t	316	27	balance	balance	NN
cord-034687-57n88v6t	316	28	of	of	IN
cord-034687-57n88v6t	316	29	GABAergic	gabaergic	NN
cord-034687-57n88v6t	316	30	and	and	CC
cord-034687-57n88v6t	316	31	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	316	32	neurotransmission	neurotransmission	NN
cord-034687-57n88v6t	317	1	Cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	317	2	CB1	CB1	NNP
cord-034687-57n88v6t	317	3	receptor	receptor	NN
cord-034687-57n88v6t	317	4	calibrates	calibrate	VBZ
cord-034687-57n88v6t	317	5	excitatory	excitatory	JJ
cord-034687-57n88v6t	317	6	synaptic	synaptic	JJ
cord-034687-57n88v6t	317	7	balance	balance	NN
cord-034687-57n88v6t	317	8	in	in	IN
cord-034687-57n88v6t	317	9	the	the	DT
cord-034687-57n88v6t	317	10	mouse	mouse	NN
cord-034687-57n88v6t	317	11	hippocampus	hippocampus	NN
cord-034687-57n88v6t	317	12	Cannabinoid	Cannabinoid	NNP
cord-034687-57n88v6t	317	13	CB1	CB1	NNP
cord-034687-57n88v6t	317	14	receptor	receptor	NN
cord-034687-57n88v6t	317	15	in	in	IN
cord-034687-57n88v6t	317	16	dorsal	dorsal	JJ
cord-034687-57n88v6t	317	17	telencephalic	telencephalic	JJ
cord-034687-57n88v6t	317	18	glutamatergic	glutamatergic	JJ
cord-034687-57n88v6t	317	19	neurons	neuron	NNS
cord-034687-57n88v6t	317	20	:	:	:
cord-034687-57n88v6t	317	21	distinctive	distinctive	JJ
cord-034687-57n88v6t	317	22	sufficiency	sufficiency	NN
cord-034687-57n88v6t	317	23	for	for	IN
cord-034687-57n88v6t	317	24	hippocampus	hippocampus	NN
cord-034687-57n88v6t	317	25	-	-	HYPH
cord-034687-57n88v6t	317	26	dependent	dependent	JJ
cord-034687-57n88v6t	317	27	and	and	CC
cord-034687-57n88v6t	317	28	amygdala	amygdala	NN
cord-034687-57n88v6t	317	29	-	-	HYPH
cord-034687-57n88v6t	317	30	dependent	dependent	JJ
cord-034687-57n88v6t	317	31	synaptic	synaptic	JJ
cord-034687-57n88v6t	317	32	and	and	CC
cord-034687-57n88v6t	317	33	behavioral	behavioral	JJ
cord-034687-57n88v6t	317	34	functions	function	NNS
cord-034687-57n88v6t	317	35	Bidirectional	bidirectional	JJ
cord-034687-57n88v6t	317	36	regulation	regulation	NN
cord-034687-57n88v6t	317	37	of	of	IN
cord-034687-57n88v6t	317	38	novelty	novelty	NN
cord-034687-57n88v6t	317	39	-	-	HYPH
cord-034687-57n88v6t	317	40	induced	induce	VBN
cord-034687-57n88v6t	317	41	behavioral	behavioral	JJ
cord-034687-57n88v6t	317	42	inhibition	inhibition	NN
cord-034687-57n88v6t	317	43	by	by	IN
cord-034687-57n88v6t	317	44	the	the	DT
cord-034687-57n88v6t	317	45	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	317	46	system	system	NN
cord-034687-57n88v6t	317	47	Circuit	Circuit	NNP
cord-034687-57n88v6t	317	48	specific	specific	JJ
cord-034687-57n88v6t	317	49	functions	function	NNS
cord-034687-57n88v6t	317	50	of	of	IN
cord-034687-57n88v6t	317	51	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	317	52	CB1	cb1	NN
cord-034687-57n88v6t	317	53	receptor	receptor	NN
cord-034687-57n88v6t	317	54	in	in	IN
cord-034687-57n88v6t	317	55	the	the	DT
cord-034687-57n88v6t	317	56	balance	balance	NN
cord-034687-57n88v6t	317	57	of	of	IN
cord-034687-57n88v6t	317	58	investigatory	investigatory	JJ
cord-034687-57n88v6t	317	59	drive	drive	NN
cord-034687-57n88v6t	317	60	and	and	CC
cord-034687-57n88v6t	317	61	exploration	exploration	NN
cord-034687-57n88v6t	317	62	A	a	DT
cord-034687-57n88v6t	317	63	runner	runner	NN
cord-034687-57n88v6t	317	64	's	's	POS
cord-034687-57n88v6t	317	65	high	high	JJ
cord-034687-57n88v6t	317	66	depends	depend	VBZ
cord-034687-57n88v6t	317	67	on	on	IN
cord-034687-57n88v6t	317	68	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	317	69	receptors	receptor	NNS
cord-034687-57n88v6t	317	70	in	in	IN
cord-034687-57n88v6t	317	71	mice	mouse	NNS
cord-034687-57n88v6t	317	72	Chemical	Chemical	NNP
cord-034687-57n88v6t	317	73	probes	probe	NNS
cord-034687-57n88v6t	317	74	to	to	IN
cord-034687-57n88v6t	317	75	potently	potently	RB
cord-034687-57n88v6t	317	76	and	and	CC
cord-034687-57n88v6t	317	77	selectively	selectively	RB
cord-034687-57n88v6t	317	78	inhibit	inhibit	VB
cord-034687-57n88v6t	317	79	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	317	80	cellular	cellular	JJ
cord-034687-57n88v6t	317	81	reuptake	reuptake	JJ
cord-034687-57n88v6t	317	82	Functional	functional	JJ
cord-034687-57n88v6t	317	83	redundancy	redundancy	NN
cord-034687-57n88v6t	317	84	between	between	IN
cord-034687-57n88v6t	317	85	canonical	canonical	JJ
cord-034687-57n88v6t	317	86	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	317	87	signaling	signal	VBG
cord-034687-57n88v6t	317	88	systems	system	NNS
cord-034687-57n88v6t	317	89	in	in	IN
cord-034687-57n88v6t	317	90	the	the	DT
cord-034687-57n88v6t	317	91	modulation	modulation	NN
cord-034687-57n88v6t	317	92	of	of	IN
cord-034687-57n88v6t	317	93	anxiety	anxiety	NN
cord-034687-57n88v6t	317	94	2-Arachidonoylglycerol	2-arachidonoylglycerol	CD
cord-034687-57n88v6t	317	95	modulation	modulation	NN
cord-034687-57n88v6t	317	96	of	of	IN
cord-034687-57n88v6t	317	97	anxiety	anxiety	NN
cord-034687-57n88v6t	317	98	and	and	CC
cord-034687-57n88v6t	317	99	stress	stress	NN
cord-034687-57n88v6t	317	100	adaptation	adaptation	NN
cord-034687-57n88v6t	317	101	:	:	:
cord-034687-57n88v6t	317	102	from	from	IN
cord-034687-57n88v6t	317	103	grass	grass	NN
cord-034687-57n88v6t	317	104	roots	root	NNS
cord-034687-57n88v6t	317	105	to	to	IN
cord-034687-57n88v6t	317	106	novel	novel	JJ
cord-034687-57n88v6t	317	107	therapeutics	therapeutic	NNS
cord-034687-57n88v6t	317	108	Influence	influence	NN
cord-034687-57n88v6t	317	109	of	of	IN
cord-034687-57n88v6t	317	110	Δ	Δ	NNP
cord-034687-57n88v6t	317	111	9	9	CD
cord-034687-57n88v6t	318	1	-tetrahydrocannabinol	-tetrahydrocannabinol	:
cord-034687-57n88v6t	318	2	on	on	IN
cord-034687-57n88v6t	318	3	long	long	JJ
cord-034687-57n88v6t	318	4	-	-	HYPH
cord-034687-57n88v6t	318	5	term	term	NN
cord-034687-57n88v6t	318	6	neural	neural	JJ
cord-034687-57n88v6t	318	7	correlates	correlate	NNS
cord-034687-57n88v6t	318	8	of	of	IN
cord-034687-57n88v6t	318	9	threat	threat	NN
cord-034687-57n88v6t	318	10	extinction	extinction	NN
cord-034687-57n88v6t	318	11	memory	memory	NN
cord-034687-57n88v6t	318	12	retention	retention	NN
cord-034687-57n88v6t	318	13	in	in	IN
cord-034687-57n88v6t	318	14	humans	human	NNS
cord-034687-57n88v6t	318	15	Termination	Termination	NNP
cord-034687-57n88v6t	318	16	of	of	IN
cord-034687-57n88v6t	318	17	acute	acute	JJ
cord-034687-57n88v6t	318	18	stress	stress	NN
cord-034687-57n88v6t	318	19	response	response	NN
cord-034687-57n88v6t	318	20	by	by	IN
cord-034687-57n88v6t	318	21	the	the	DT
cord-034687-57n88v6t	318	22	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	318	23	system	system	NN
cord-034687-57n88v6t	318	24	is	be	VBZ
cord-034687-57n88v6t	318	25	regulated	regulate	VBN
cord-034687-57n88v6t	318	26	through	through	IN
cord-034687-57n88v6t	318	27	lysine	lysine	NN
cord-034687-57n88v6t	318	28	-	-	HYPH
cord-034687-57n88v6t	318	29	specific	specific	JJ
cord-034687-57n88v6t	318	30	demethylase	demethylase	NN
cord-034687-57n88v6t	318	31	1-mediated	1-mediated	CD
cord-034687-57n88v6t	318	32	transcriptional	transcriptional	JJ
cord-034687-57n88v6t	318	33	repression	repression	NN
cord-034687-57n88v6t	318	34	of	of	IN
cord-034687-57n88v6t	318	35	2-AG	2-ag	CD
cord-034687-57n88v6t	318	36	hydrolases	hydrolase	NNS
cord-034687-57n88v6t	318	37	ABHD6	abhd6	XX
cord-034687-57n88v6t	318	38	and	and	CC
cord-034687-57n88v6t	318	39	MAGL	MAGL	NNP
cord-034687-57n88v6t	318	40	Cannabinoid	Cannabinoid	NNP
cord-034687-57n88v6t	318	41	CB1	CB1	NNP
cord-034687-57n88v6t	318	42	receptors	receptor	NNS
cord-034687-57n88v6t	318	43	in	in	IN
cord-034687-57n88v6t	318	44	distinct	distinct	JJ
cord-034687-57n88v6t	318	45	circuits	circuit	NNS
cord-034687-57n88v6t	318	46	of	of	IN
cord-034687-57n88v6t	318	47	the	the	DT
cord-034687-57n88v6t	318	48	extended	extended	JJ
cord-034687-57n88v6t	318	49	amygdala	amygdala	NN
cord-034687-57n88v6t	318	50	determine	determine	VB
cord-034687-57n88v6t	318	51	fear	fear	NN
cord-034687-57n88v6t	318	52	responsiveness	responsiveness	NN
cord-034687-57n88v6t	318	53	to	to	IN
cord-034687-57n88v6t	318	54	unpredictable	unpredictable	JJ
cord-034687-57n88v6t	318	55	threat	threat	NN
cord-034687-57n88v6t	318	56	Cognitive	cognitive	JJ
cord-034687-57n88v6t	318	57	impairment	impairment	NN
cord-034687-57n88v6t	318	58	induced	induce	VBN
cord-034687-57n88v6t	318	59	by	by	IN
cord-034687-57n88v6t	318	60	Delta9-tetrahydrocannabinol	delta9-tetrahydrocannabinol	NN
cord-034687-57n88v6t	318	61	occurs	occur	VBZ
cord-034687-57n88v6t	318	62	through	through	IN
cord-034687-57n88v6t	318	63	heteromers	heteromer	NNS
cord-034687-57n88v6t	318	64	between	between	IN
cord-034687-57n88v6t	318	65	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	318	66	CB	CB	NNP
cord-034687-57n88v6t	318	67	1	1	CD
cord-034687-57n88v6t	318	68	and	and	CC
cord-034687-57n88v6t	318	69	serotonin	serotonin	NN
cord-034687-57n88v6t	318	70	5-HT	5-ht	CD
cord-034687-57n88v6t	318	71	2A	2a	CD
cord-034687-57n88v6t	318	72	receptors	receptor	NNS
cord-034687-57n88v6t	318	73	Cannabinoid	Cannabinoid	NNP
cord-034687-57n88v6t	318	74	type-1	type-1	NNP
cord-034687-57n88v6t	318	75	receptor	receptor	NN
cord-034687-57n88v6t	318	76	signaling	signal	VBG
cord-034687-57n88v6t	318	77	in	in	IN
cord-034687-57n88v6t	318	78	central	central	JJ
cord-034687-57n88v6t	318	79	serotonergic	serotonergic	JJ
cord-034687-57n88v6t	318	80	neurons	neuron	NNS
cord-034687-57n88v6t	318	81	regulates	regulate	VBZ
cord-034687-57n88v6t	318	82	anxiety	anxiety	NN
cord-034687-57n88v6t	318	83	-	-	HYPH
cord-034687-57n88v6t	318	84	like	like	JJ
cord-034687-57n88v6t	318	85	behavior	behavior	NN
cord-034687-57n88v6t	318	86	and	and	CC
cord-034687-57n88v6t	318	87	sociability	sociability	NN
cord-034687-57n88v6t	318	88	Target	target	NN
cord-034687-57n88v6t	318	89	-	-	HYPH
cord-034687-57n88v6t	318	90	specific	specific	JJ
cord-034687-57n88v6t	318	91	modulation	modulation	NN
cord-034687-57n88v6t	318	92	of	of	IN
cord-034687-57n88v6t	318	93	the	the	DT
cord-034687-57n88v6t	318	94	descending	descend	VBG
cord-034687-57n88v6t	318	95	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	318	96	cortex	cortex	NN
cord-034687-57n88v6t	318	97	inputs	input	NNS
cord-034687-57n88v6t	318	98	to	to	IN
cord-034687-57n88v6t	318	99	the	the	DT
cord-034687-57n88v6t	318	100	dorsal	dorsal	JJ
cord-034687-57n88v6t	318	101	raphe	raphe	NNP
cord-034687-57n88v6t	318	102	nucleus	nucleus	NN
cord-034687-57n88v6t	318	103	by	by	IN
cord-034687-57n88v6t	318	104	cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	319	1	The	the	DT
cord-034687-57n88v6t	319	2	lateral	lateral	JJ
cord-034687-57n88v6t	319	3	habenula	habenula	NN
cord-034687-57n88v6t	319	4	directs	direct	VBZ
cord-034687-57n88v6t	319	5	coping	cope	VBG
cord-034687-57n88v6t	319	6	styles	style	NNS
cord-034687-57n88v6t	319	7	under	under	IN
cord-034687-57n88v6t	319	8	conditions	condition	NNS
cord-034687-57n88v6t	319	9	of	of	IN
cord-034687-57n88v6t	319	10	stress	stress	NN
cord-034687-57n88v6t	319	11	via	via	IN
cord-034687-57n88v6t	319	12	recruitment	recruitment	NN
cord-034687-57n88v6t	319	13	of	of	IN
cord-034687-57n88v6t	319	14	the	the	DT
cord-034687-57n88v6t	319	15	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	319	16	system	system	NN
cord-034687-57n88v6t	320	1	Cannabinoids	cannabinoid	NNS
cord-034687-57n88v6t	320	2	reverse	reverse	VBP
cord-034687-57n88v6t	320	3	the	the	DT
cord-034687-57n88v6t	320	4	effects	effect	NNS
cord-034687-57n88v6t	320	5	of	of	IN
cord-034687-57n88v6t	320	6	early	early	JJ
cord-034687-57n88v6t	320	7	stress	stress	NN
cord-034687-57n88v6t	320	8	on	on	IN
cord-034687-57n88v6t	320	9	neurocognitive	neurocognitive	JJ
cord-034687-57n88v6t	320	10	performance	performance	NN
cord-034687-57n88v6t	320	11	in	in	IN
cord-034687-57n88v6t	320	12	adulthood	adulthood	NN
cord-034687-57n88v6t	320	13	Sex	sex	NN
cord-034687-57n88v6t	320	14	-	-	HYPH
cord-034687-57n88v6t	320	15	dependence	dependence	NN
cord-034687-57n88v6t	320	16	of	of	IN
cord-034687-57n88v6t	320	17	anxiety	anxiety	NN
cord-034687-57n88v6t	320	18	-	-	HYPH
cord-034687-57n88v6t	320	19	like	like	JJ
cord-034687-57n88v6t	320	20	behavior	behavior	NN
cord-034687-57n88v6t	320	21	in	in	IN
cord-034687-57n88v6t	320	22	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	320	23	receptor	receptor	NN
cord-034687-57n88v6t	320	24	1	1	CD
cord-034687-57n88v6t	320	25	(	(	-LRB-
cord-034687-57n88v6t	320	26	Cnr1	cnr1	JJ
cord-034687-57n88v6t	320	27	)	)	-RRB-
cord-034687-57n88v6t	320	28	knockout	knockout	NN
cord-034687-57n88v6t	320	29	mice	mouse	NNS
cord-034687-57n88v6t	320	30	Effects	effect	NNS
cord-034687-57n88v6t	320	31	of	of	IN
cord-034687-57n88v6t	320	32	CB1	cb1	NN
cord-034687-57n88v6t	320	33	receptor	receptor	NN
cord-034687-57n88v6t	320	34	antagonism	antagonism	NN
cord-034687-57n88v6t	320	35	and	and	CC
cord-034687-57n88v6t	320	36	stress	stress	NN
cord-034687-57n88v6t	320	37	exposures	exposure	NNS
cord-034687-57n88v6t	320	38	in	in	IN
cord-034687-57n88v6t	320	39	adolescence	adolescence	NN
cord-034687-57n88v6t	320	40	on	on	IN
cord-034687-57n88v6t	320	41	socioemotional	socioemotional	JJ
cord-034687-57n88v6t	320	42	behaviours	behaviour	NNS
cord-034687-57n88v6t	320	43	,	,	,
cord-034687-57n88v6t	320	44	neuroendocrine	neuroendocrine	JJ
cord-034687-57n88v6t	320	45	stress	stress	NN
cord-034687-57n88v6t	320	46	responses	response	NNS
cord-034687-57n88v6t	320	47	,	,	,
cord-034687-57n88v6t	320	48	and	and	CC
cord-034687-57n88v6t	320	49	expression	expression	NN
cord-034687-57n88v6t	320	50	of	of	IN
cord-034687-57n88v6t	320	51	relevant	relevant	JJ
cord-034687-57n88v6t	320	52	proteins	protein	NNS
cord-034687-57n88v6t	320	53	in	in	IN
cord-034687-57n88v6t	320	54	the	the	DT
cord-034687-57n88v6t	320	55	hippocampus	hippocampus	NN
cord-034687-57n88v6t	320	56	and	and	CC
cord-034687-57n88v6t	320	57	prefrontal	prefrontal	JJ
cord-034687-57n88v6t	320	58	cortex	cortex	NNS
cord-034687-57n88v6t	320	59	in	in	IN
cord-034687-57n88v6t	320	60	rats	rat	NNS
cord-034687-57n88v6t	320	61	Sex	sex	NN
cord-034687-57n88v6t	320	62	-	-	HYPH
cord-034687-57n88v6t	320	63	dependent	dependent	JJ
cord-034687-57n88v6t	320	64	effects	effect	NNS
cord-034687-57n88v6t	320	65	of	of	IN
cord-034687-57n88v6t	320	66	in	in	IN
cord-034687-57n88v6t	320	67	utero	utero	NN
cord-034687-57n88v6t	320	68	cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	320	69	exposure	exposure	NN
cord-034687-57n88v6t	320	70	on	on	IN
cord-034687-57n88v6t	320	71	cortical	cortical	JJ
cord-034687-57n88v6t	320	72	function	function	NN
cord-034687-57n88v6t	320	73	Lifelong	lifelong	JJ
cord-034687-57n88v6t	320	74	epigenetic	epigenetic	JJ
cord-034687-57n88v6t	320	75	programming	programming	NN
cord-034687-57n88v6t	320	76	of	of	IN
cord-034687-57n88v6t	320	77	cortical	cortical	JJ
cord-034687-57n88v6t	320	78	architecture	architecture	NN
cord-034687-57n88v6t	320	79	by	by	IN
cord-034687-57n88v6t	320	80	maternal	maternal	JJ
cord-034687-57n88v6t	320	81	'	'	``
cord-034687-57n88v6t	320	82	Western	western	JJ
cord-034687-57n88v6t	320	83	'	'	''
cord-034687-57n88v6t	320	84	diet	diet	NN
cord-034687-57n88v6t	320	85	during	during	IN
cord-034687-57n88v6t	320	86	pregnancy	pregnancy	NN
cord-034687-57n88v6t	320	87	Cannabinoid	cannabinoid	NN
cord-034687-57n88v6t	320	88	and	and	CC
cord-034687-57n88v6t	320	89	nicotine	nicotine	NN
cord-034687-57n88v6t	320	90	exposure	exposure	NN
cord-034687-57n88v6t	320	91	during	during	IN
cord-034687-57n88v6t	320	92	adolescence	adolescence	NN
cord-034687-57n88v6t	320	93	induces	induce	VBZ
cord-034687-57n88v6t	320	94	sex	sex	NN
cord-034687-57n88v6t	320	95	-	-	HYPH
cord-034687-57n88v6t	320	96	specific	specific	JJ
cord-034687-57n88v6t	320	97	effects	effect	NNS
cord-034687-57n88v6t	320	98	on	on	IN
cord-034687-57n88v6t	320	99	anxiety	anxiety	NN
cord-034687-57n88v6t	320	100	-	-	HYPH
cord-034687-57n88v6t	320	101	and	and	CC
cord-034687-57n88v6t	320	102	reward	reward	NN
cord-034687-57n88v6t	320	103	-	-	HYPH
cord-034687-57n88v6t	320	104	related	relate	VBN
cord-034687-57n88v6t	320	105	behaviors	behavior	NNS
cord-034687-57n88v6t	320	106	during	during	IN
cord-034687-57n88v6t	320	107	adulthood	adulthood	NN
cord-034687-57n88v6t	320	108	Disrupting	disrupt	VBG
cord-034687-57n88v6t	320	109	the	the	DT
cord-034687-57n88v6t	320	110	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	320	111	system	system	NN
cord-034687-57n88v6t	320	112	in	in	IN
cord-034687-57n88v6t	320	113	early	early	JJ
cord-034687-57n88v6t	320	114	adolescence	adolescence	NN
cord-034687-57n88v6t	320	115	negatively	negatively	RB
cord-034687-57n88v6t	320	116	impacts	impact	VBZ
cord-034687-57n88v6t	320	117	sociability	sociability	NN
cord-034687-57n88v6t	320	118	Effect	effect	NN
cord-034687-57n88v6t	320	119	of	of	IN
cord-034687-57n88v6t	320	120	repeated	repeat	VBN
cord-034687-57n88v6t	320	121	juvenile	juvenile	JJ
cord-034687-57n88v6t	320	122	exposure	exposure	NN
cord-034687-57n88v6t	320	123	to	to	IN
cord-034687-57n88v6t	320	124	Δ	δ	NN
cord-034687-57n88v6t	320	125	9	9	CD
cord-034687-57n88v6t	320	126	-tetrahydrocannabinol	-tetrahydrocannabinol	CD
cord-034687-57n88v6t	320	127	on	on	IN
cord-034687-57n88v6t	320	128	anxiety	anxiety	NN
cord-034687-57n88v6t	320	129	-	-	HYPH
cord-034687-57n88v6t	320	130	related	relate	VBN
cord-034687-57n88v6t	320	131	behavior	behavior	NN
cord-034687-57n88v6t	320	132	and	and	CC
cord-034687-57n88v6t	320	133	social	social	JJ
cord-034687-57n88v6t	320	134	interactions	interaction	NNS
cord-034687-57n88v6t	320	135	in	in	IN
cord-034687-57n88v6t	320	136	adolescent	adolescent	JJ
cord-034687-57n88v6t	320	137	rats	rat	NNS
cord-034687-57n88v6t	321	1	Effects	effect	NNS
cord-034687-57n88v6t	321	2	in	in	IN
cord-034687-57n88v6t	321	3	rats	rat	NNS
cord-034687-57n88v6t	321	4	of	of	IN
cord-034687-57n88v6t	321	5	adolescent	adolescent	JJ
cord-034687-57n88v6t	321	6	exposure	exposure	NN
cord-034687-57n88v6t	321	7	to	to	IN
cord-034687-57n88v6t	321	8	cannabis	cannabis	NN
cord-034687-57n88v6t	321	9	smoke	smoke	NN
cord-034687-57n88v6t	321	10	or	or	CC
cord-034687-57n88v6t	321	11	THC	thc	NN
cord-034687-57n88v6t	321	12	on	on	IN
cord-034687-57n88v6t	321	13	emotional	emotional	JJ
cord-034687-57n88v6t	321	14	behavior	behavior	NN
cord-034687-57n88v6t	321	15	and	and	CC
cord-034687-57n88v6t	321	16	cognitive	cognitive	JJ
cord-034687-57n88v6t	321	17	function	function	NN
cord-034687-57n88v6t	321	18	in	in	IN
cord-034687-57n88v6t	321	19	adulthood	adulthood	NN
cord-034687-57n88v6t	321	20	Cannabis	Cannabis	NNP
cord-034687-57n88v6t	321	21	use	use	VBP
cord-034687-57n88v6t	321	22	in	in	IN
cord-034687-57n88v6t	321	23	early	early	JJ
cord-034687-57n88v6t	321	24	adolescence	adolescence	NN
cord-034687-57n88v6t	321	25	:	:	:
cord-034687-57n88v6t	321	26	evidence	evidence	NN
cord-034687-57n88v6t	321	27	of	of	IN
cord-034687-57n88v6t	321	28	amygdala	amygdala	NN
cord-034687-57n88v6t	321	29	hypersensitivity	hypersensitivity	NN
cord-034687-57n88v6t	321	30	to	to	IN
cord-034687-57n88v6t	321	31	signals	signal	NNS
cord-034687-57n88v6t	321	32	of	of	IN
cord-034687-57n88v6t	321	33	threat	threat	NN
cord-034687-57n88v6t	321	34	Grey	Grey	NNP
cord-034687-57n88v6t	321	35	matter	matter	NN
cord-034687-57n88v6t	321	36	volume	volume	NN
cord-034687-57n88v6t	321	37	differences	difference	NNS
cord-034687-57n88v6t	321	38	associated	associate	VBN
cord-034687-57n88v6t	321	39	with	with	IN
cord-034687-57n88v6t	321	40	extremely	extremely	RB
cord-034687-57n88v6t	321	41	low	low	JJ
cord-034687-57n88v6t	321	42	levels	level	NNS
cord-034687-57n88v6t	321	43	of	of	IN
cord-034687-57n88v6t	321	44	cannabis	cannabis	NN
cord-034687-57n88v6t	321	45	use	use	NN
cord-034687-57n88v6t	321	46	in	in	IN
cord-034687-57n88v6t	321	47	adolescence	adolescence	NN
cord-034687-57n88v6t	321	48	Sartori	Sartori	NNP
cord-034687-57n88v6t	321	49	SB	SB	NNP
cord-034687-57n88v6t	321	50	,	,	,
cord-034687-57n88v6t	321	51	Singewald	Singewald	NNP
cord-034687-57n88v6t	321	52	N.	N.	NNP
cord-034687-57n88v6t	321	53	Novel	Novel	NNP
cord-034687-57n88v6t	321	54	pharmacological	pharmacological	JJ
cord-034687-57n88v6t	321	55	targets	target	NNS
cord-034687-57n88v6t	321	56	in	in	IN
cord-034687-57n88v6t	321	57	drug	drug	NN
cord-034687-57n88v6t	321	58	development	development	NN
cord-034687-57n88v6t	321	59	for	for	IN
cord-034687-57n88v6t	321	60	the	the	DT
cord-034687-57n88v6t	321	61	treatment	treatment	NN
cord-034687-57n88v6t	321	62	of	of	IN
cord-034687-57n88v6t	321	63	anxiety	anxiety	NN
cord-034687-57n88v6t	321	64	and	and	CC
cord-034687-57n88v6t	321	65	anxiety	anxiety	NN
cord-034687-57n88v6t	321	66	-	-	HYPH
cord-034687-57n88v6t	321	67	related	relate	VBN
cord-034687-57n88v6t	321	68	disorders	disorder	NNS
cord-034687-57n88v6t	322	1	The	the	DT
cord-034687-57n88v6t	322	2	potential	potential	NN
cord-034687-57n88v6t	322	3	of	of	IN
cord-034687-57n88v6t	322	4	inhibitors	inhibitor	NNS
cord-034687-57n88v6t	322	5	of	of	IN
cord-034687-57n88v6t	322	6	endocannabinoid	endocannabinoid	NN
cord-034687-57n88v6t	322	7	metabolism	metabolism	NN
cord-034687-57n88v6t	322	8	for	for	IN
cord-034687-57n88v6t	322	9	drug	drug	NN
cord-034687-57n88v6t	322	10	development	development	NN
cord-034687-57n88v6t	322	11	:	:	:
cord-034687-57n88v6t	322	12	a	a	DT
cord-034687-57n88v6t	322	13	critical	critical	JJ
cord-034687-57n88v6t	322	14	review	review	NN
cord-034687-57n88v6t	323	1	Pregnenolone	pregnenolone	NN
cord-034687-57n88v6t	323	2	can	can	MD
cord-034687-57n88v6t	323	3	protect	protect	VB
cord-034687-57n88v6t	323	4	the	the	DT
cord-034687-57n88v6t	323	5	brain	brain	NN
cord-034687-57n88v6t	323	6	from	from	IN
cord-034687-57n88v6t	323	7	cannabis	cannabis	NN
cord-034687-57n88v6t	323	8	intoxication	intoxication	NN