id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-034687-57n88v6t	Maldonado, Rafael	The endocannabinoid system in modulating fear, anxiety, and stress	2020-09-17		.txt	text/plain	6653	358	33	We also review the alterations in the activity of the endocannabinoid system during fear, stress, and anxiety, and the pathophysiological role of each component of this system in the control of these protective emotional responses that also trigger pathological emotional disorders. Importantly, the deletion of CB 1 R in forebrain GABAergic neurons of GABA-CB 1 R knockouts leads to an augmentation of active coping strategies in the fear conditioning paradigm, possibly due to an increased inhibition of glutamatergic cells in the basolateral amygdala (BLA), which reduces central amygdala (CeA) excitation. 24 Glucocorticoids released after acute stressors activate G-protein membrane receptors in the BLA, promoting a rapid increase in retrograde 2-AG signaling that leads to suppression of GABAergic synaptic inputs onto BLA principal neurons, inducing fast increases in anxiety-like behavior. 34 Chronic stress induces prominent and sustained changes in the endocannabinoid system, leading to decreases in CB 1 R signaling in brain regions related with emotional processing such as the hippocampus, nucleus accumbens, PFC, dorsal raphe nucleus, hypothalamus, and amygdala.	./cache/cord-034687-57n88v6t.txt	./txt/cord-034687-57n88v6t.txt