id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352172-g0jiaenw	Stoevesandt, Oda	Protein microarrays: high-throughput tools for proteomics	2014-01-09		.txt	text/plain	7464	373	32	While conventionally made by the spotting of purified proteins, recent advances in technology have made it possible to produce protein microarrays through in situ cell-free synthesis directly from corresponding DNA arrays. Protein microarray technology has rapidly developed into one of the most active areas in biotechnology today, and is being increasingly applied for the high-throughput discovery of molecular interactions, profiling of protein expression and monitoring of protein modifications. While genome sequencing and annotations provide comprehensive information on protein-encoding genes, and DNA arrays analyze gene expression at the mRNA level, these technologies need to be complemented by functional proteomic studies in order to better understand protein activities, expression levels and interactions at the system level. A reverse-phase micro array approach has been successfully applied to discover distinct pathway-activation differences among breast cancer cell lines, demonstrating the use of array-based ana lysis for multiple pharmacodynamic biomarkers responding to targeted kinase inhibitors [108] .	./cache/cord-352172-g0jiaenw.txt	./txt/cord-352172-g0jiaenw.txt