id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341305-zf97tcwe	Ge, Shikun	Canine Parvovirus is diagnosed and neutralized by chicken IgY-scFv generated against the virus capsid protein	2020-09-03		.txt	text/plain	3690	182	50	The CPV-VLP and CPV-VP2 protein showed similar reaction values to the purified scFv in the ELISA test, and the results of ELISA analysis using IgY-scFv toward CPV clinical samples were consistent with commercial immunochromatographic assay (ICA) and PCR detection, the scFv did not show cross reactivity with canine distemper virus (CDV) and canine coronavirus (CCV). This study revealed the feasibility of a novel functional antibody fragment development strategy by generating diversified avian IgY-scFv libraries towards the pathogenic target of interest for both detection and therapeutic purposes in veterinary medicine. Functional antibody fragments (i.e.: scFv, Fab) generated by phage-display technology have been not yet routinely evaluated and applied in the veterinary medicine despite it has been well confirmed that such engineered antibodies offer a series of advantages over polyclonal and full-length monoclonal antibodies.	./cache/cord-341305-zf97tcwe.txt	./txt/cord-341305-zf97tcwe.txt