id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-330218-l5q3n3ri	Foss, Stian	TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity	2015-10-26		.txt	text/plain	7824	376	41	Neutralization of viruses by antibodies is predicted to depend on high-affinity binding to specific epitopes of surface-exposed viral proteins that are required for binding to target cell receptors (4) . These effector functions are induced upon binding of antibody-virus immune complexes to classical Fc c receptors (FccRs) expressed on the surface of hematopoietic cells such as natural killer (NK) cells, macrophages, and dendritic cells, which results in clearance and induction of T-cell responses (8) . Low antibody-virus stoichiometry may also result in inefficient FccR-mediated effector functions by immune cells as efficient phagocytosis requires the formation of immune complexes and cross-binding to cell-surface FccRs. In addition, as TRIM21 also engages IgM and IgA, it is likely to contribute to early protection, and at the gate of entry of most viral pathogens, the mucosal barrier.	./cache/cord-330218-l5q3n3ri.txt	./txt/cord-330218-l5q3n3ri.txt