id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326673-p8qbxi57	Kitching, R. P.	The interference by maternally-derived antibody with active immunization of farm animals against foot-and-mouth disease	1995-12-31		.txt	text/plain	4788	197	45	This maternally-derived antibody (MDA) provides immediate protection against infection with FMD virus, but also interferes with the development of active immunity following vaccination. However, this maternally derived antibody (MDA) is equally effective in preventing the response to active vaccination in the young animal as it is in providing protection against disease. In the case of FMD vaccination in pigs, Francis and Black (1986) concluded that the complete immunological unresponsiveness seen in the first 2 weeks of life was due to immaturity of the immune system and antigen blockade by high titre MDA, and as this titre declined an active suppression of T and/or B cells occurred to variable degrees. Francis and Black (1984) found no evidence in the pig that vaccination in the presence of MDA depressed the specific antibody to FMD virus. The effect of maternally derived antibodies on the response of calves to vaccination against foot-and-mouth disease	./cache/cord-326673-p8qbxi57.txt	./txt/cord-326673-p8qbxi57.txt