id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319884-d8n0aokl	Natesan, Mohan	Protein Microarrays and Biomarkers of Infectious Disease	2010-12-16		.txt	text/plain	7088	359	36	Fluorescencebased detection of protein interactions is similar to gene array methods, and data analysis often employs approaches previously developed for genome and transcription studies. A standard assay for measuring antibody interactions with proteins of the vaccinia proteome microarray was first developed with a pool of therapeutic human sera collected from vaccinia-immune individuals (VIg) and this data was compared to results obtained from individuals vaccinated against smallpox using Dryvax. Results from this study suggested that antibodies from vaccination recognized a small number of proteins shared with pathogenic viral strains, while recovery from infection also involved humoral immunity to antigens uniquely recognized within the monkeypox virus proteome (unpublished data). For example, a protein array produced from the outer membrane proteins of Pseudomonas aeruginosa was constructed [38] to study the immune response in patients, and several antibody-binding antigens were identified by this group as potential diagnostic markers.	./cache/cord-319884-d8n0aokl.txt	./txt/cord-319884-d8n0aokl.txt