id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302312-1pm17l5d	Quinteros, Daniela A.	Therapeutic use of monoclonal antibodies: general aspects and challenges for drug delivery	2017-03-31		.txt	text/plain	10875	493	33	In therapy, the development of targeted drug delivery represents, together with tissue repair, the main applications of antibody-conjugated nanoparticles. In addition to their own properties as pathogens or toxin neutralizers, as well as in the recruitment of immune elements (complement, improving phagocytosis, cytotoxicity antibody dependent by natural killer cells, etc.), they could carry several elements (toxins, drugs, fluorochroms, or even nanoparticles, etc.) and be used in several diagnostic procedures, or even in therapy to destroy a specific target. To treat HER2 positive breast cancer, anti-HER2 humanized Mabs are commonly used, although advances can be made in targeted cellular localization via conjugation strategy through a nano-particulate system focusing on surface modified ligand/receptor-mediated nano-therapy to target the tumor cell at the molecular level. Bio-conjugation strategies of therapeutic agents loaded nanoparticles with Mabs have exhibited a targeted drug delivery approach both in vitro and in vivo.	./cache/cord-302312-1pm17l5d.txt	./txt/cord-302312-1pm17l5d.txt