id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282817-vtzpf2wr	Byrne, Hannah	A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications	2013-10-02		.txt	text/plain	8419	417	34	Despite significant positive clinical results, especially in the case of hematological malignancies, adverse clinical outcomes and animal studies have highlighted underlying limitations of mAbs. Accordingly, many strategies have been developed in order to improve the specificity and control the functions of antibodies. The BiTE format potentially overcomes several limiting factors relating to the biological activity of tumor-directed bsAbs. BiTEs combine the minimal binding domains (Fv fragments) of two different mAbs fused together by a short flexible linker that allows free rotation of the two arms, and thus facilitates optimal antibody:antigen interaction [28] . bsAbs are attractive in such assays because they simplify the detection steps and are currently used for the development of simple, rapid, and highly sensitive immunoassays for the detection of bacterial and viral infectious diseases and in cancer diagnostics. CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation	./cache/cord-282817-vtzpf2wr.txt	./txt/cord-282817-vtzpf2wr.txt