id author title date pages extension mime words sentences flesch summary cache txt cord-282081-qaagup4d Flicker, Sabine Nanobodies—Useful Tools for Allergy Treatment? 2020-09-30 .txt text/plain 5062 247 30 Their superior properties such as chemical stability, high affinity to a broad spectrum of epitopes, low immunogenicity, ease of their generation, selection and production proved nanobodies also to be remarkable to investigate their efficacy for passive treatment of type I allergy, an exaggerated immune reaction to foreign antigens with increasing global prevalence. Similar to the evaluation of conventional antibodies with the focus to identify effective protective monoclones, generated nanobodies have to be assessed first for their allergen specificity, epitope recognition, cross-reactivity to homologous allergens present in related species, for their affinity to their corresponding allergens and most importantly for their ability to inhibit patients'IgE binding to these allergens (Figures 2A-C) . ./cache/cord-282081-qaagup4d.txt ./txt/cord-282081-qaagup4d.txt