id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274756-nnm1n09a	Varadé, Jezabel	Human immunology and immunotherapy: main achievements and challenges	2020-09-02		.txt	text/plain	19144	920	38	The development of different types of immunotherapies, including vaccines (prophylactic and therapeutic), and the use of pathogens, monoclonal antibodies, recombinant proteins, cytokines, and cellular immunotherapies, are changing the way in which we approach many diseases, especially cancer. In addition to those showing the essential role of LTi cells in the formation of secondary lymphoid organs during embryogenesis and the postnatal development of intestinal lymphoid clusters, recent studies also provide evidence that subsets of ILCs express multiple factors that modulate the adaptive immune response in health and disease 27, 28 . Autoimmunity: In the case of therapeutic vaccines for autoimmune diseases, such as multiple sclerosis, diabetes, Myasthenia gravis or Guillain Barré syndrome, the intention is to induce tolerance to self-antigens through the activation of regulatory cells (Tregs and Bregs) and tolerogenic dendritic cells, thus avoiding the immune response to self-components 211 .	./cache/cord-274756-nnm1n09a.txt	./txt/cord-274756-nnm1n09a.txt