id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274557-2071770h	Späth, Peter J.	On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events	2015-02-05		.txt	text/plain	10243	530	40	i.e., cold-ethanol or ion-exchange chromatography, contaminants, route of application, i.e., intra muscular (IMIG), intravenous (IVIG), or subcutaneous (SCIG), the rate of increase of the exogenous IgG in the circulation of the recipient over time and, last but not least an eventually existing risk factor from patients' side ( Figure 1 ) as well as incorrect handling of the concentrate are factors having a role in inducing non-infectious AEs related to administration of IgG concentrates ( Table 1) . The complement-mediated AEs were considered to be caused by aggregates in the product ("spontaneous complement activation" or anti-complementary activity or ACA) or by in vivo formation of immune complexes (ICs, patient's condition related; e.g., subclinical infections or the unnoticed presence of anti-IgA antibodies) and therefore only IgG concentrates with low or absent ACA is accepted by authorities for human use.	./cache/cord-274557-2071770h.txt	./txt/cord-274557-2071770h.txt