id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268417-6eyetb5i	Mandel, Benjamin	Neutralization of Animal Viruses	1978-12-31		.txt	text/plain	23012	1239	43	Somewhat earlier, Morgan (1945'1 had reported that discrepancies in the quantitative aspects of the neutralization of WEE virus by immune rabbit sera were related to the use of fresh or heated serum, and that the addition of complement to the latter tended to eliminate the discrepancies. Further studies (Radwan et al., 1973) showed that the addition of complement to virus complexed with dependent antibody eventually resulted in lysis of the viral membrane. It was also shown (Yoshino and Taniguchi, 1966 ) that antibodies induced in guinea pigs by immunization, and in humans following herpes infection, were initially dependent and later independent of complement for neutralizing activity. A relevant observation has been made in several studies; neutralization of infectious virus-antibody complexes by antiglobulin also shows a single-hit mechanism, and at a rate that exceeds the rate of the homotypic reaction.	./cache/cord-268417-6eyetb5i.txt	./txt/cord-268417-6eyetb5i.txt