id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267601-3ahmyicn	Renegar, Kathryn B.	Passive Immunization: Systemic and Mucosal	2007-05-09		.txt	text/plain	8078	405	43	Both rats and mice can actively transport IgG from the gut into the serum for approximately 2 weeks (see Combined Prenatal and Postnatal Transfer earlier in this chapter); thus, observed protection could be due either to antibody in the milk bathing the mucosal surfaces or to maternal antibody being transported into the serum and secretions of the offspring. Only a limited number of studies on the transport of antibodies into respiratory secretions have been reported, but the results have shown that selective transport of passively administered serum IgA into the respiratory tract is possible in sheep and mice. (1994) determined that passively administered monoclonal pIgA isotype-switch variants, generated from IgG hybridomas producing antibodies specific for bacterial respiratory tract pathogens, were selectively transported relative to IgG into both the upper and lower respiratory tract secretions of mice. To determine whether intravenously administered pIgA antiinfluenza monoclonal antibody could mediate protection against local influenza virus challenge, passively immunized mice were challenged intranasally while awake with influenza virus.	./cache/cord-267601-3ahmyicn.txt	./txt/cord-267601-3ahmyicn.txt