id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254531-pv55re2x	Mestecky, Jiri	Specific antibody activity, glycan heterogeneity and polyreactivity contribute to the protective activity of S-IgA at mucosal surfaces	2009-06-04		.txt	text/plain	4108	237	36	In addition to mechanical barriers and a variety of innate defense factors, mucosal immunoglobulins (Igs) provide protection by two complementary mechanisms: specific antibody activity and innate, Ig glycan-mediated binding, both of which serve to contain the mucosal microbiota in its physiological niche. Bacteria Table 1 Examples of glycans as adhesion sites and receptors for selected bacteria and viruses that colonize, or infect, mucosal surfaces (adapted from [1, 26, 29, [60] [61] [62] [63] [64] [65] [66] [67] [68] [69] [70] [71] [72] [73] [74] [75] [76] [77] [78] 132] endogenous to the intestinal tract, oral cavity, and probably also the respiratory and genital tracts, are coated in vivo with S-IgA [9, 13, 17, [31] [32] [33] [34] [35] [36] [37] [38] [39] that limits their epithelial adherence and penetration, thereby confining them to the mucosal surfaces. Parallel structural and functional exploration of the principles of adaptive (specific antibody) and innate (glycan) S-IgA-mediated immunity is likely to generate novel approaches to the design of broadly protective compounds that work by selectively interfering with the adherence and penetration of pathogens, or that contain the commensal microbiota residing at mucosal surfaces.	./cache/cord-254531-pv55re2x.txt	./txt/cord-254531-pv55re2x.txt