id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-103255-4k13re9y	Daniell, Henry	Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants	2001-05-01		.txt	text/plain	4362	205	42	The production of recombinant proteins in plants has many potential advantages for generating biopharmaceuticals relevant to clinical medicine. In the decade since the expression and assembly of immunoglobulin (Ig) heavy and light chains into functional antibodies was first shown in transgenic tobacco, plants have proven to be versatile production systems for many forms of antibodies. Other advantages of tobacco include its relative ease of genetic manipulation, production of large numbers of seeds (up to a million per plant) and an impending need to explore alternate uses for this hazardous crop. However, the most attractive species for expressing subunit vaccine components should have high levels of soluble protein that is stable during storage; seed crops such as cereals are particularly suitable. Induction of a protective antibody response to foot and mouth disease in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1	./cache/cord-103255-4k13re9y.txt	./txt/cord-103255-4k13re9y.txt