id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-031060-0o9agjiq	Yuan, Tom Z	Rapid exploration of the epitope coverage produced by an Ebola survivor to guide the discovery of therapeutic antibody cocktails	2020-08-01		.txt	text/plain	3913	159	36	Incorporating epitope binning on hundreds of antibodies during early stage antibody characterization ensures access to a library's full epitope coverage, aids in the identification of high quality reagents within the library that recapitulate this diversity for use in other studies, and ultimately enables the rational development of therapeutic cocktails that take advantage of multiple mechanisms of action such as cooperative synergistic effects to enhance neutralization function and minimize the risk of mutagenic escape. Despite ligand attrition and the stringent requirement for premixed antibodies to achieve antigen saturation, which reduced our heat map to 52 analytes x 233 ligands, we were able in this non-optimized 'first pass' binning to assign 234 antibodies to one of seven epitope communities without the use of benchmark antibodies (Supplemental Table S1 ).	./cache/cord-031060-0o9agjiq.txt	./txt/cord-031060-0o9agjiq.txt