id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-010680-lc1onm53	Patel, Ami	In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies	2020-03-10		.txt	text/plain	13044	659	41	Some of these hurdles may be overcome through transient in vivo gene delivery platforms, such as non-viral synthetic plasmid DNA and messenger RNA vectors that are engineered to encode optimized mAb genes. In this review, we focus on nucleic acid delivery of antibody employing synthetic plasmid DNA vector platforms, and RNA delivery, these being important approaches that are advancing simple, rapid, in vivo expression and having an impact in animal models of infectious diseases and cancer, among others. The original studies surrounding in vivo antibody gene delivery focused primarily on gene delivery using recombinant viral vectors such as AAV and adenovirus (Ad), which were advanced clinically, building on work in the traditional gene therapy-based field. Additional studies to help evaluate fully human pDNA-mAbs in mouse models would be highly informative for both non-viral and viral delivery and provide an important path forward for preclinical evaluation of in vivo-delivered antibodies [109] .	./cache/cord-010680-lc1onm53.txt	./txt/cord-010680-lc1onm53.txt