id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009446-8keu2uay	Kreer, Christoph	Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies	2020-01-01		.txt	text/plain	6658	355	39	Focusing on the development of highly potent broadly neutralizing antibodies against HIV-1, we discuss how a detailed knowledge of the human B cell repertoire may support the development of novel vaccination strategies. Indeed, the generation of optimized bait proteins [30] or native-like envelope trimers [45] were critical steps to improve the isolation of potent HIV-1 broadly neutralizing antibodies (bNAbs) by antigen-specific sorting strategies [31, [46] [47] [48] . Only a small fraction of HIV-1-infected individuals develop highly potent bNAbs and detailed analyses of B cell receptors and antibodies at a single cell level have been limited to a few dozen subjects. Thus, a detailed understanding of the naïve B cell receptor repertoire and the constantly adapting antibody response in the context of HIV-1 infection can be highly informative for vaccine design.	./cache/cord-009446-8keu2uay.txt	./txt/cord-009446-8keu2uay.txt