id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005913-1vo1o6w8	Matis, Louis A.	Complement-specific antibodies: Designing novel anti-inflammatories	1995		.txt	text/plain	1918	89	30	The complement system is composed of more than 20 serum proteins that interact in a precise series of enzymatic cleavage and membrane binding events leading to the generation of products with immunoprotective, immunoregulatory, and proinflammatory properties 12 • Complement can be activated through either of two distinct enzymatic cascades, referred to as the classical and alternative pathways (Fig. 1) . Using a monoclonal antibody specific for mouse CS, we have shown that systemic anti-CS monoclonal antibody administration efficiently inhibited complement in vivo (inhibiting serum haemolytic activity for as long as six to seven days after a single intravenous injection), and that treatment with anti-CS monoclonal antibody was therapeutically effective in two distinct models of immune complex nephritis and autoimmune disease (Y. In addition, humanized recombinant anti-CS monoclonal antibody and scFv that retain the binding affinity and complement inhibitory activity of their murine counterparts have been produced by CDR grafting (M.	./cache/cord-005913-1vo1o6w8.txt	./txt/cord-005913-1vo1o6w8.txt