id	sid	tid	token	lemma	pos
cord-281188-0cql96hu	1	1	key	key	JJ
cord-281188-0cql96hu	1	2	:	:	:
cord-281188-0cql96hu	1	3	cord-281188	cord-281188	NN
cord-281188-0cql96hu	1	4	-	-	HYPH
cord-281188-0cql96hu	1	5	0cql96hu	0cql96hu	CD
cord-281188-0cql96hu	2	1	authors	author	NNS
cord-281188-0cql96hu	2	2	:	:	:
cord-281188-0cql96hu	2	3	Baquero	Baquero	NNP
cord-281188-0cql96hu	2	4	,	,	,
cord-281188-0cql96hu	2	5	Fernando	Fernando	NNP
cord-281188-0cql96hu	2	6	;	;	:
cord-281188-0cql96hu	2	7	Levin	Levin	NNP
cord-281188-0cql96hu	2	8	,	,	,
cord-281188-0cql96hu	2	9	Bruce	Bruce	NNP
cord-281188-0cql96hu	2	10	R.	R.	NNP
cord-281188-0cql96hu	2	11	title	title	NN
cord-281188-0cql96hu	2	12	:	:	:
cord-281188-0cql96hu	3	1	Proximate	proximate	JJ
cord-281188-0cql96hu	3	2	and	and	CC
cord-281188-0cql96hu	3	3	ultimate	ultimate	JJ
cord-281188-0cql96hu	3	4	causes	cause	NNS
cord-281188-0cql96hu	3	5	of	of	IN
cord-281188-0cql96hu	3	6	the	the	DT
cord-281188-0cql96hu	3	7	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	3	8	action	action	NN
cord-281188-0cql96hu	3	9	of	of	IN
cord-281188-0cql96hu	3	10	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	3	11	date	date	NN
cord-281188-0cql96hu	3	12	:	:	:
cord-281188-0cql96hu	3	13	2020	2020	CD
cord-281188-0cql96hu	3	14	-	-	SYM
cord-281188-0cql96hu	3	15	10	10	CD
cord-281188-0cql96hu	3	16	-	-	HYPH
cord-281188-0cql96hu	3	17	06	06	CD
cord-281188-0cql96hu	3	18	journal	journal	NN
cord-281188-0cql96hu	3	19	:	:	:
cord-281188-0cql96hu	4	1	Nat	Nat	NNP
cord-281188-0cql96hu	4	2	Rev	Rev	NNP
cord-281188-0cql96hu	4	3	Microbiol	Microbiol	NNP
cord-281188-0cql96hu	4	4	DOI	DOI	NNP
cord-281188-0cql96hu	4	5	:	:	:
cord-281188-0cql96hu	5	1	10.1038	10.1038	CD
cord-281188-0cql96hu	5	2	/	/	SYM
cord-281188-0cql96hu	5	3	s41579	s41579	NNP
cord-281188-0cql96hu	5	4	-	-	HYPH
cord-281188-0cql96hu	5	5	020	020	CD
cord-281188-0cql96hu	6	1	-00443	-00443	NNP
cord-281188-0cql96hu	6	2	-	-	HYPH
cord-281188-0cql96hu	6	3	1	1	CD
cord-281188-0cql96hu	6	4	sha	sha	NNP
cord-281188-0cql96hu	6	5	:	:	:
cord-281188-0cql96hu	7	1	a956ff7ddc320bbb6827d703af9e9ebd2d9e768c	a956ff7ddc320bbb6827d703af9e9ebd2d9e768c	NNP
cord-281188-0cql96hu	7	2	doc_id	doc_id	CD
cord-281188-0cql96hu	8	1	:	:	:
cord-281188-0cql96hu	8	2	281188	281188	CD
cord-281188-0cql96hu	8	3	cord_uid	cord_uid	NNS
cord-281188-0cql96hu	8	4	:	:	:
cord-281188-0cql96hu	9	1	0cql96hu	0cql96hu	CD
cord-281188-0cql96hu	10	1	During	during	IN
cord-281188-0cql96hu	10	2	the	the	DT
cord-281188-0cql96hu	10	3	past	past	JJ
cord-281188-0cql96hu	10	4	85	85	CD
cord-281188-0cql96hu	10	5	years	year	NNS
cord-281188-0cql96hu	10	6	of	of	IN
cord-281188-0cql96hu	10	7	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	10	8	use	use	NN
cord-281188-0cql96hu	10	9	,	,	,
cord-281188-0cql96hu	10	10	we	-PRON-	PRP
cord-281188-0cql96hu	10	11	have	have	VBP
cord-281188-0cql96hu	10	12	learned	learn	VBN
cord-281188-0cql96hu	10	13	a	a	DT
cord-281188-0cql96hu	10	14	great	great	JJ
cord-281188-0cql96hu	10	15	deal	deal	NN
cord-281188-0cql96hu	10	16	about	about	IN
cord-281188-0cql96hu	10	17	how	how	WRB
cord-281188-0cql96hu	10	18	these	these	DT
cord-281188-0cql96hu	10	19	‘	'	``
cord-281188-0cql96hu	10	20	miracle	miracle	NN
cord-281188-0cql96hu	10	21	’	'	''
cord-281188-0cql96hu	10	22	drugs	drug	NNS
cord-281188-0cql96hu	10	23	work	work	VBP
cord-281188-0cql96hu	10	24	.	.	.
cord-281188-0cql96hu	11	1	We	-PRON-	PRP
cord-281188-0cql96hu	11	2	know	know	VBP
cord-281188-0cql96hu	11	3	the	the	DT
cord-281188-0cql96hu	11	4	molecular	molecular	JJ
cord-281188-0cql96hu	11	5	structures	structure	NNS
cord-281188-0cql96hu	11	6	and	and	CC
cord-281188-0cql96hu	11	7	interactions	interaction	NNS
cord-281188-0cql96hu	11	8	of	of	IN
cord-281188-0cql96hu	11	9	these	these	DT
cord-281188-0cql96hu	11	10	drugs	drug	NNS
cord-281188-0cql96hu	11	11	and	and	CC
cord-281188-0cql96hu	11	12	their	-PRON-	PRP$
cord-281188-0cql96hu	11	13	targets	target	NNS
cord-281188-0cql96hu	11	14	and	and	CC
cord-281188-0cql96hu	11	15	the	the	DT
cord-281188-0cql96hu	11	16	effects	effect	NNS
cord-281188-0cql96hu	11	17	on	on	IN
cord-281188-0cql96hu	11	18	the	the	DT
cord-281188-0cql96hu	11	19	structure	structure	NN
cord-281188-0cql96hu	11	20	,	,	,
cord-281188-0cql96hu	11	21	physiology	physiology	NN
cord-281188-0cql96hu	11	22	and	and	CC
cord-281188-0cql96hu	11	23	replication	replication	NN
cord-281188-0cql96hu	11	24	of	of	IN
cord-281188-0cql96hu	11	25	bacteria	bacteria	NNS
cord-281188-0cql96hu	11	26	.	.	.
cord-281188-0cql96hu	12	1	Collectively	collectively	RB
cord-281188-0cql96hu	12	2	,	,	,
cord-281188-0cql96hu	12	3	we	-PRON-	PRP
cord-281188-0cql96hu	12	4	know	know	VBP
cord-281188-0cql96hu	12	5	a	a	DT
cord-281188-0cql96hu	12	6	great	great	JJ
cord-281188-0cql96hu	12	7	deal	deal	NN
cord-281188-0cql96hu	12	8	about	about	IN
cord-281188-0cql96hu	12	9	these	these	DT
cord-281188-0cql96hu	12	10	proximate	proximate	JJ
cord-281188-0cql96hu	12	11	mechanisms	mechanism	NNS
cord-281188-0cql96hu	12	12	of	of	IN
cord-281188-0cql96hu	12	13	action	action	NN
cord-281188-0cql96hu	12	14	for	for	IN
cord-281188-0cql96hu	12	15	virtually	virtually	RB
cord-281188-0cql96hu	12	16	all	all	DT
cord-281188-0cql96hu	12	17	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	12	18	in	in	IN
cord-281188-0cql96hu	12	19	current	current	JJ
cord-281188-0cql96hu	12	20	use	use	NN
cord-281188-0cql96hu	12	21	.	.	.
cord-281188-0cql96hu	13	1	What	what	WP
cord-281188-0cql96hu	13	2	we	-PRON-	PRP
cord-281188-0cql96hu	13	3	do	do	VBP
cord-281188-0cql96hu	13	4	not	not	RB
cord-281188-0cql96hu	13	5	know	know	VB
cord-281188-0cql96hu	13	6	is	be	VBZ
cord-281188-0cql96hu	13	7	the	the	DT
cord-281188-0cql96hu	13	8	ultimate	ultimate	JJ
cord-281188-0cql96hu	13	9	mechanism	mechanism	NN
cord-281188-0cql96hu	13	10	of	of	IN
cord-281188-0cql96hu	13	11	action	action	NN
cord-281188-0cql96hu	13	12	;	;	:
cord-281188-0cql96hu	13	13	that	that	RB
cord-281188-0cql96hu	13	14	is	is	RB
cord-281188-0cql96hu	13	15	,	,	,
cord-281188-0cql96hu	13	16	how	how	WRB
cord-281188-0cql96hu	13	17	these	these	DT
cord-281188-0cql96hu	13	18	drugs	drug	NNS
cord-281188-0cql96hu	13	19	irreversibly	irreversibly	RB
cord-281188-0cql96hu	13	20	terminate	terminate	VBP
cord-281188-0cql96hu	13	21	the	the	DT
cord-281188-0cql96hu	13	22	‘	'	``
cord-281188-0cql96hu	13	23	individuality	individuality	NN
cord-281188-0cql96hu	13	24	’	'	''
cord-281188-0cql96hu	13	25	of	of	IN
cord-281188-0cql96hu	13	26	bacterial	bacterial	JJ
cord-281188-0cql96hu	13	27	cells	cell	NNS
cord-281188-0cql96hu	13	28	by	by	IN
cord-281188-0cql96hu	13	29	removing	remove	VBG
cord-281188-0cql96hu	13	30	barriers	barrier	NNS
cord-281188-0cql96hu	13	31	to	to	IN
cord-281188-0cql96hu	13	32	the	the	DT
cord-281188-0cql96hu	13	33	external	external	JJ
cord-281188-0cql96hu	13	34	world	world	NN
cord-281188-0cql96hu	13	35	(	(	-LRB-
cord-281188-0cql96hu	13	36	cell	cell	NN
cord-281188-0cql96hu	13	37	envelopes	envelope	NNS
cord-281188-0cql96hu	13	38	)	)	-RRB-
cord-281188-0cql96hu	13	39	or	or	CC
cord-281188-0cql96hu	13	40	by	by	IN
cord-281188-0cql96hu	13	41	destroying	destroy	VBG
cord-281188-0cql96hu	13	42	their	-PRON-	PRP$
cord-281188-0cql96hu	13	43	genetic	genetic	JJ
cord-281188-0cql96hu	13	44	identity	identity	NN
cord-281188-0cql96hu	13	45	(	(	-LRB-
cord-281188-0cql96hu	13	46	DNA	DNA	NNP
cord-281188-0cql96hu	13	47	)	)	-RRB-
cord-281188-0cql96hu	13	48	.	.	.
cord-281188-0cql96hu	14	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	14	2	have	have	VBP
cord-281188-0cql96hu	14	3	many	many	JJ
cord-281188-0cql96hu	14	4	different	different	JJ
cord-281188-0cql96hu	14	5	‘	'	``
cord-281188-0cql96hu	14	6	mechanisms	mechanism	NNS
cord-281188-0cql96hu	14	7	of	of	IN
cord-281188-0cql96hu	14	8	action	action	NN
cord-281188-0cql96hu	14	9	’	'	''
cord-281188-0cql96hu	14	10	that	that	WDT
cord-281188-0cql96hu	14	11	converge	converge	VBP
cord-281188-0cql96hu	14	12	to	to	IN
cord-281188-0cql96hu	14	13	irreversible	irreversible	JJ
cord-281188-0cql96hu	14	14	lethal	lethal	JJ
cord-281188-0cql96hu	14	15	effects	effect	NNS
cord-281188-0cql96hu	14	16	.	.	.
cord-281188-0cql96hu	15	1	In	in	IN
cord-281188-0cql96hu	15	2	this	this	DT
cord-281188-0cql96hu	15	3	Perspective	perspective	NN
cord-281188-0cql96hu	15	4	,	,	,
cord-281188-0cql96hu	15	5	we	-PRON-	PRP
cord-281188-0cql96hu	15	6	consider	consider	VBP
cord-281188-0cql96hu	15	7	what	what	WP
cord-281188-0cql96hu	15	8	our	-PRON-	PRP$
cord-281188-0cql96hu	15	9	knowledge	knowledge	NN
cord-281188-0cql96hu	15	10	of	of	IN
cord-281188-0cql96hu	15	11	the	the	DT
cord-281188-0cql96hu	15	12	proximate	proximate	JJ
cord-281188-0cql96hu	15	13	mechanisms	mechanism	NNS
cord-281188-0cql96hu	15	14	of	of	IN
cord-281188-0cql96hu	15	15	action	action	NN
cord-281188-0cql96hu	15	16	of	of	IN
cord-281188-0cql96hu	15	17	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	15	18	and	and	CC
cord-281188-0cql96hu	15	19	the	the	DT
cord-281188-0cql96hu	15	20	pharmacodynamics	pharmacodynamic	NNS
cord-281188-0cql96hu	15	21	of	of	IN
cord-281188-0cql96hu	15	22	their	-PRON-	PRP$
cord-281188-0cql96hu	15	23	interaction	interaction	NN
cord-281188-0cql96hu	15	24	with	with	IN
cord-281188-0cql96hu	15	25	bacteria	bacteria	NNS
cord-281188-0cql96hu	15	26	tell	tell	VBP
cord-281188-0cql96hu	15	27	us	-PRON-	PRP
cord-281188-0cql96hu	15	28	about	about	IN
cord-281188-0cql96hu	15	29	the	the	DT
cord-281188-0cql96hu	15	30	ultimate	ultimate	JJ
cord-281188-0cql96hu	15	31	mechanisms	mechanism	NNS
cord-281188-0cql96hu	15	32	by	by	IN
cord-281188-0cql96hu	15	33	which	which	WDT
cord-281188-0cql96hu	15	34	these	these	DT
cord-281188-0cql96hu	15	35	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	15	36	kill	kill	VBP
cord-281188-0cql96hu	15	37	bacteria	bacteria	NNS
cord-281188-0cql96hu	15	38	.	.	.
cord-281188-0cql96hu	16	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	16	2	have	have	VBP
cord-281188-0cql96hu	16	3	been	be	VBN
cord-281188-0cql96hu	16	4	used	use	VBN
cord-281188-0cql96hu	16	5	to	to	TO
cord-281188-0cql96hu	16	6	treat	treat	VB
cord-281188-0cql96hu	16	7	bacterial	bacterial	JJ
cord-281188-0cql96hu	16	8	infections	infection	NNS
cord-281188-0cql96hu	16	9	for	for	IN
cord-281188-0cql96hu	16	10	nearly	nearly	RB
cord-281188-0cql96hu	16	11	85	85	CD
cord-281188-0cql96hu	16	12	years	year	NNS
cord-281188-0cql96hu	16	13	,	,	,
cord-281188-0cql96hu	16	14	or	or	CC
cord-281188-0cql96hu	16	15	more	more	JJR
cord-281188-0cql96hu	16	16	than	than	IN
cord-281188-0cql96hu	16	17	a	a	DT
cord-281188-0cql96hu	16	18	century	century	NN
cord-281188-0cql96hu	16	19	if	if	IN
cord-281188-0cql96hu	16	20	Paul	Paul	NNP
cord-281188-0cql96hu	16	21	Ehrlich	Ehrlich	NNP
cord-281188-0cql96hu	16	22	's	's	POS
cord-281188-0cql96hu	16	23	arsenate	arsenate	NN
cord-281188-0cql96hu	16	24	,	,	,
cord-281188-0cql96hu	16	25	also	also	RB
cord-281188-0cql96hu	16	26	called	call	VBD
cord-281188-0cql96hu	16	27	'	'	``
cord-281188-0cql96hu	16	28	compound	compound	NN
cord-281188-0cql96hu	16	29	606	606	CD
cord-281188-0cql96hu	16	30	'	'	''
cord-281188-0cql96hu	16	31	or	or	CC
cord-281188-0cql96hu	16	32	'	'	``
cord-281188-0cql96hu	16	33	Salvarsan	Salvarsan	NNP
cord-281188-0cql96hu	16	34	'	'	''
cord-281188-0cql96hu	16	35	,	,	,
cord-281188-0cql96hu	16	36	is	be	VBZ
cord-281188-0cql96hu	16	37	included	include	VBN
cord-281188-0cql96hu	16	38	1	1	CD
cord-281188-0cql96hu	16	39	.	.	.
cord-281188-0cql96hu	17	1	During	during	IN
cord-281188-0cql96hu	17	2	this	this	DT
cord-281188-0cql96hu	17	3	time	time	NN
cord-281188-0cql96hu	17	4	,	,	,
cord-281188-0cql96hu	17	5	we	-PRON-	PRP
cord-281188-0cql96hu	17	6	have	have	VBP
cord-281188-0cql96hu	17	7	learned	learn	VBN
cord-281188-0cql96hu	17	8	a	a	DT
cord-281188-0cql96hu	17	9	great	great	JJ
cord-281188-0cql96hu	17	10	deal	deal	NN
cord-281188-0cql96hu	17	11	about	about	IN
cord-281188-0cql96hu	17	12	these	these	DT
cord-281188-0cql96hu	17	13	drugs	drug	NNS
cord-281188-0cql96hu	17	14	.	.	.
cord-281188-0cql96hu	18	1	We	-PRON-	PRP
cord-281188-0cql96hu	18	2	know	know	VBP
cord-281188-0cql96hu	18	3	their	-PRON-	PRP$
cord-281188-0cql96hu	18	4	molecular	molecular	JJ
cord-281188-0cql96hu	18	5	structure	structure	NN
cord-281188-0cql96hu	18	6	and	and	CC
cord-281188-0cql96hu	18	7	that	that	DT
cord-281188-0cql96hu	18	8	of	of	IN
cord-281188-0cql96hu	18	9	their	-PRON-	PRP$
cord-281188-0cql96hu	18	10	targets	target	NNS
cord-281188-0cql96hu	18	11	in	in	IN
cord-281188-0cql96hu	18	12	the	the	DT
cord-281188-0cql96hu	18	13	bacteria	bacteria	NNS
cord-281188-0cql96hu	18	14	,	,	,
cord-281188-0cql96hu	18	15	how	how	WRB
cord-281188-0cql96hu	18	16	they	-PRON-	PRP
cord-281188-0cql96hu	18	17	bind	bind	VBP
cord-281188-0cql96hu	18	18	to	to	IN
cord-281188-0cql96hu	18	19	those	those	DT
cord-281188-0cql96hu	18	20	targets	target	NNS
cord-281188-0cql96hu	18	21	and	and	CC
cord-281188-0cql96hu	18	22	the	the	DT
cord-281188-0cql96hu	18	23	immediate	immediate	JJ
cord-281188-0cql96hu	18	24	consequences	consequence	NNS
cord-281188-0cql96hu	18	25	of	of	IN
cord-281188-0cql96hu	18	26	that	that	DT
cord-281188-0cql96hu	18	27	binding	bind	VBG
cord-281188-0cql96hu	18	28	on	on	IN
cord-281188-0cql96hu	18	29	the	the	DT
cord-281188-0cql96hu	18	30	physiology	physiology	NN
cord-281188-0cql96hu	18	31	and	and	CC
cord-281188-0cql96hu	18	32	structure	structure	NN
cord-281188-0cql96hu	18	33	of	of	IN
cord-281188-0cql96hu	18	34	the	the	DT
cord-281188-0cql96hu	18	35	exposed	expose	VBN
cord-281188-0cql96hu	18	36	bacteria	bacteria	NNS
cord-281188-0cql96hu	18	37	.	.	.
cord-281188-0cql96hu	19	1	Curiously	curiously	RB
cord-281188-0cql96hu	19	2	,	,	,
cord-281188-0cql96hu	19	3	for	for	IN
cord-281188-0cql96hu	19	4	the	the	DT
cord-281188-0cql96hu	19	5	vast	vast	JJ
cord-281188-0cql96hu	19	6	majority	majority	NN
cord-281188-0cql96hu	19	7	of	of	IN
cord-281188-0cql96hu	19	8	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	19	9	,	,	,
cord-281188-0cql96hu	19	10	what	what	WP
cord-281188-0cql96hu	19	11	is	be	VBZ
cord-281188-0cql96hu	19	12	not	not	RB
cord-281188-0cql96hu	19	13	known	know	VBN
cord-281188-0cql96hu	19	14	,	,	,
cord-281188-0cql96hu	19	15	and	and	CC
cord-281188-0cql96hu	19	16	is	be	VBZ
cord-281188-0cql96hu	19	17	subject	subject	JJ
cord-281188-0cql96hu	19	18	of	of	IN
cord-281188-0cql96hu	19	19	some	some	DT
cord-281188-0cql96hu	19	20	controversy	controversy	NN
cord-281188-0cql96hu	19	21	,	,	,
cord-281188-0cql96hu	19	22	is	be	VBZ
cord-281188-0cql96hu	19	23	how	how	WRB
cord-281188-0cql96hu	19	24	these	these	DT
cord-281188-0cql96hu	19	25	drugs	drug	NNS
cord-281188-0cql96hu	19	26	actually	actually	RB
cord-281188-0cql96hu	19	27	kill	kill	VBP
cord-281188-0cql96hu	19	28	bacteria	bacteria	NNS
cord-281188-0cql96hu	19	29	2	2	CD
cord-281188-0cql96hu	19	30	and/or	and/or	CC
cord-281188-0cql96hu	19	31	prevent	prevent	VB
cord-281188-0cql96hu	19	32	their	-PRON-	PRP$
cord-281188-0cql96hu	19	33	replication	replication	NN
cord-281188-0cql96hu	19	34	3	3	CD
cord-281188-0cql96hu	19	35	.	.	.
cord-281188-0cql96hu	20	1	For	for	IN
cord-281188-0cql96hu	20	2	example	example	NN
cord-281188-0cql96hu	20	3	,	,	,
cord-281188-0cql96hu	20	4	why	why	WRB
cord-281188-0cql96hu	20	5	do	do	VBP
cord-281188-0cql96hu	20	6	some	some	DT
cord-281188-0cql96hu	20	7	ribosome	ribosome	NN
cord-281188-0cql96hu	20	8	-	-	HYPH
cord-281188-0cql96hu	20	9	targeting	target	VBG
cord-281188-0cql96hu	20	10	drugs	drug	NNS
cord-281188-0cql96hu	20	11	,	,	,
cord-281188-0cql96hu	20	12	such	such	JJ
cord-281188-0cql96hu	20	13	as	as	IN
cord-281188-0cql96hu	20	14	most	most	JJS
cord-281188-0cql96hu	20	15	but	but	CC
cord-281188-0cql96hu	20	16	not	not	RB
cord-281188-0cql96hu	20	17	all	all	DT
cord-281188-0cql96hu	20	18	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	20	19	,	,	,
cord-281188-0cql96hu	20	20	rapidly	rapidly	RB
cord-281188-0cql96hu	20	21	kill	kill	VBP
cord-281188-0cql96hu	20	22	bacteria	bacteria	NNS
cord-281188-0cql96hu	20	23	,	,	,
cord-281188-0cql96hu	20	24	whereas	whereas	IN
cord-281188-0cql96hu	20	25	others	other	NNS
cord-281188-0cql96hu	20	26	,	,	,
cord-281188-0cql96hu	20	27	such	such	JJ
cord-281188-0cql96hu	20	28	as	as	IN
cord-281188-0cql96hu	20	29	the	the	DT
cord-281188-0cql96hu	20	30	macrolides	macrolide	NNS
cord-281188-0cql96hu	20	31	,	,	,
cord-281188-0cql96hu	20	32	prevent	prevent	VBP
cord-281188-0cql96hu	20	33	replication	replication	NN
cord-281188-0cql96hu	20	34	and	and	CC
cord-281188-0cql96hu	20	35	kill	kill	VB
cord-281188-0cql96hu	20	36	at	at	IN
cord-281188-0cql96hu	20	37	low	low	JJ
cord-281188-0cql96hu	20	38	rates	rate	NNS
cord-281188-0cql96hu	20	39	if	if	IN
cord-281188-0cql96hu	20	40	at	at	RB
cord-281188-0cql96hu	20	41	all	all	RB
cord-281188-0cql96hu	20	42	?	?	.
cord-281188-0cql96hu	21	1	Why	why	WRB
cord-281188-0cql96hu	21	2	is	be	VBZ
cord-281188-0cql96hu	21	3	inhibition	inhibition	NN
cord-281188-0cql96hu	21	4	of	of	IN
cord-281188-0cql96hu	21	5	protein	protein	NN
cord-281188-0cql96hu	21	6	synthesis	synthesis	NN
cord-281188-0cql96hu	21	7	lethal	lethal	NN
cord-281188-0cql96hu	21	8	in	in	IN
cord-281188-0cql96hu	21	9	some	some	DT
cord-281188-0cql96hu	21	10	cases	case	NNS
cord-281188-0cql96hu	21	11	and	and	CC
cord-281188-0cql96hu	21	12	only	only	RB
cord-281188-0cql96hu	21	13	static	static	JJ
cord-281188-0cql96hu	21	14	in	in	IN
cord-281188-0cql96hu	21	15	others	other	NNS
cord-281188-0cql96hu	21	16	?	?	.
cord-281188-0cql96hu	22	1	It	-PRON-	PRP
cord-281188-0cql96hu	22	2	is	be	VBZ
cord-281188-0cql96hu	22	3	useful	useful	JJ
cord-281188-0cql96hu	22	4	to	to	TO
cord-281188-0cql96hu	22	5	put	put	VB
cord-281188-0cql96hu	22	6	this	this	DT
cord-281188-0cql96hu	22	7	question	question	NN
cord-281188-0cql96hu	22	8	into	into	IN
cord-281188-0cql96hu	22	9	the	the	DT
cord-281188-0cql96hu	22	10	context	context	NN
cord-281188-0cql96hu	22	11	of	of	IN
cord-281188-0cql96hu	22	12	what	what	WP
cord-281188-0cql96hu	22	13	Ernst	Ernst	NNP
cord-281188-0cql96hu	22	14	Mayr	Mayr	NNP
cord-281188-0cql96hu	22	15	described	describe	VBD
cord-281188-0cql96hu	22	16	as	as	IN
cord-281188-0cql96hu	22	17	cause	cause	NN
cord-281188-0cql96hu	22	18	and	and	CC
cord-281188-0cql96hu	22	19	effect	effect	NN
cord-281188-0cql96hu	22	20	in	in	IN
cord-281188-0cql96hu	22	21	evolutionary	evolutionary	JJ
cord-281188-0cql96hu	22	22	biology	biology	NN
cord-281188-0cql96hu	22	23	[	[	-LRB-
cord-281188-0cql96hu	22	24	4	4	CD
cord-281188-0cql96hu	22	25	]	]	-RRB-
cord-281188-0cql96hu	22	26	[	[	-LRB-
cord-281188-0cql96hu	22	27	5	5	CD
cord-281188-0cql96hu	22	28	]	]	-RRB-
cord-281188-0cql96hu	22	29	[	[	-LRB-
cord-281188-0cql96hu	22	30	6	6	CD
cord-281188-0cql96hu	22	31	]	]	-RRB-
cord-281188-0cql96hu	22	32	.	.	.
cord-281188-0cql96hu	23	1	Mayr	Mayr	NNP
cord-281188-0cql96hu	23	2	used	use	VBD
cord-281188-0cql96hu	23	3	'	'	``
cord-281188-0cql96hu	23	4	proximate	proximate	JJ
cord-281188-0cql96hu	23	5	causation	causation	NN
cord-281188-0cql96hu	23	6	'	'	''
cord-281188-0cql96hu	23	7	to	to	TO
cord-281188-0cql96hu	23	8	refer	refer	VB
cord-281188-0cql96hu	23	9	to	to	IN
cord-281188-0cql96hu	23	10	immediate	immediate	JJ
cord-281188-0cql96hu	23	11	factors	factor	NNS
cord-281188-0cql96hu	23	12	(	(	-LRB-
cord-281188-0cql96hu	23	13	for	for	IN
cord-281188-0cql96hu	23	14	example	example	NN
cord-281188-0cql96hu	23	15	,	,	,
cord-281188-0cql96hu	23	16	physiology	physiology	NN
cord-281188-0cql96hu	23	17	or	or	CC
cord-281188-0cql96hu	23	18	mutation	mutation	NN
cord-281188-0cql96hu	23	19	)	)	-RRB-
cord-281188-0cql96hu	23	20	of	of	IN
cord-281188-0cql96hu	23	21	processes	process	NNS
cord-281188-0cql96hu	23	22	and	and	CC
cord-281188-0cql96hu	23	23	'	'	``
cord-281188-0cql96hu	23	24	ultimate	ultimate	JJ
cord-281188-0cql96hu	23	25	causation	causation	NN
cord-281188-0cql96hu	23	26	'	'	''
cord-281188-0cql96hu	23	27	to	to	TO
cord-281188-0cql96hu	23	28	refer	refer	VB
cord-281188-0cql96hu	23	29	to	to	IN
cord-281188-0cql96hu	23	30	the	the	DT
cord-281188-0cql96hu	23	31	'	'	``
cord-281188-0cql96hu	23	32	final	final	JJ
cord-281188-0cql96hu	23	33	reasons	reason	NNS
cord-281188-0cql96hu	23	34	'	'	''
cord-281188-0cql96hu	23	35	for	for	IN
cord-281188-0cql96hu	23	36	the	the	DT
cord-281188-0cql96hu	23	37	outcome	outcome	NN
cord-281188-0cql96hu	23	38	(	(	-LRB-
cord-281188-0cql96hu	23	39	for	for	IN
cord-281188-0cql96hu	23	40	example	example	NN
cord-281188-0cql96hu	23	41	,	,	,
cord-281188-0cql96hu	23	42	by	by	IN
cord-281188-0cql96hu	23	43	convention	convention	NN
cord-281188-0cql96hu	23	44	.	.	.
cord-281188-0cql96hu	24	1	In	in	IN
cord-281188-0cql96hu	24	2	an	an	DT
cord-281188-0cql96hu	24	3	essay	essay	NN
cord-281188-0cql96hu	24	4	written	write	VBN
cord-281188-0cql96hu	24	5	many	many	JJ
cord-281188-0cql96hu	24	6	years	year	NNS
cord-281188-0cql96hu	24	7	ago	ago	RB
cord-281188-0cql96hu	24	8	,	,	,
cord-281188-0cql96hu	24	9	Peter	Peter	NNP
cord-281188-0cql96hu	24	10	Medawar	Medawar	NNP
cord-281188-0cql96hu	24	11	defined	define	VBD
cord-281188-0cql96hu	24	12	death	death	NN
cord-281188-0cql96hu	24	13	as	as	IN
cord-281188-0cql96hu	24	14	the	the	DT
cord-281188-0cql96hu	24	15	non	non	JJ
cord-281188-0cql96hu	24	16	-	-	JJ
cord-281188-0cql96hu	24	17	reversible	reversible	JJ
cord-281188-0cql96hu	24	18	loss	loss	NN
cord-281188-0cql96hu	24	19	of	of	IN
cord-281188-0cql96hu	24	20	individuality	individuality	NN
cord-281188-0cql96hu	24	21	,	,	,
cord-281188-0cql96hu	24	22	a	a	DT
cord-281188-0cql96hu	24	23	state	state	NN
cord-281188-0cql96hu	24	24	that	that	WDT
cord-281188-0cql96hu	24	25	requires	require	VBZ
cord-281188-0cql96hu	24	26	physical	physical	JJ
cord-281188-0cql96hu	24	27	destruction	destruction	NN
cord-281188-0cql96hu	24	28	of	of	IN
cord-281188-0cql96hu	24	29	the	the	DT
cord-281188-0cql96hu	24	30	biological	biological	JJ
cord-281188-0cql96hu	24	31	"	"	''
cord-281188-0cql96hu	24	32	structure	structure	NN
cord-281188-0cql96hu	24	33	of	of	IN
cord-281188-0cql96hu	24	34	the	the	DT
cord-281188-0cql96hu	24	35	self	self	NN
cord-281188-0cql96hu	24	36	"	"	''
cord-281188-0cql96hu	24	37	(	(	-LRB-
cord-281188-0cql96hu	24	38	ref	ref	NN
cord-281188-0cql96hu	24	39	.	.	NNP
cord-281188-0cql96hu	24	40	7	7	CD
cord-281188-0cql96hu	24	41	)	)	-RRB-
cord-281188-0cql96hu	24	42	,	,	,
cord-281188-0cql96hu	24	43	dissipation	dissipation	NN
cord-281188-0cql96hu	24	44	of	of	IN
cord-281188-0cql96hu	24	45	the	the	DT
cord-281188-0cql96hu	24	46	internal	internal	JJ
cord-281188-0cql96hu	24	47	content	content	NN
cord-281188-0cql96hu	24	48	of	of	IN
cord-281188-0cql96hu	24	49	the	the	DT
cord-281188-0cql96hu	24	50	cell	cell	NN
cord-281188-0cql96hu	24	51	by	by	IN
cord-281188-0cql96hu	24	52	irreversible	irreversible	JJ
cord-281188-0cql96hu	24	53	membrane	membrane	NN
cord-281188-0cql96hu	24	54	damage	damage	NN
cord-281188-0cql96hu	24	55	or	or	CC
cord-281188-0cql96hu	24	56	irreversible	irreversible	JJ
cord-281188-0cql96hu	24	57	breaks	break	NNS
cord-281188-0cql96hu	24	58	and	and	CC
cord-281188-0cql96hu	24	59	disorganization	disorganization	NN
cord-281188-0cql96hu	24	60	of	of	IN
cord-281188-0cql96hu	24	61	its	-PRON-	PRP$
cord-281188-0cql96hu	24	62	individual	individual	JJ
cord-281188-0cql96hu	24	63	genetic	genetic	JJ
cord-281188-0cql96hu	24	64	content	content	NN
cord-281188-0cql96hu	24	65	produces	produce	VBZ
cord-281188-0cql96hu	24	66	death	death	NN
cord-281188-0cql96hu	24	67	.	.	.
cord-281188-0cql96hu	25	1	Other	other	JJ
cord-281188-0cql96hu	25	2	changes	change	NNS
cord-281188-0cql96hu	25	3	in	in	IN
cord-281188-0cql96hu	25	4	the	the	DT
cord-281188-0cql96hu	25	5	structural	structural	JJ
cord-281188-0cql96hu	25	6	and	and	CC
cord-281188-0cql96hu	25	7	physiological	physiological	JJ
cord-281188-0cql96hu	25	8	status	status	NN
cord-281188-0cql96hu	25	9	quo	quo	NN
cord-281188-0cql96hu	25	10	may	may	MD
cord-281188-0cql96hu	25	11	not	not	RB
cord-281188-0cql96hu	25	12	result	result	VB
cord-281188-0cql96hu	25	13	in	in	IN
cord-281188-0cql96hu	25	14	death	death	NN
cord-281188-0cql96hu	25	15	,	,	,
cord-281188-0cql96hu	25	16	but	but	CC
cord-281188-0cql96hu	25	17	from	from	IN
cord-281188-0cql96hu	25	18	the	the	DT
cord-281188-0cql96hu	25	19	limited	limited	JJ
cord-281188-0cql96hu	25	20	perspective	perspective	NN
cord-281188-0cql96hu	25	21	of	of	IN
cord-281188-0cql96hu	25	22	bench	bench	NN
cord-281188-0cql96hu	25	23	scientists	scientist	NNS
cord-281188-0cql96hu	25	24	conveniently	conveniently	RB
cord-281188-0cql96hu	25	25	working	work	VBG
cord-281188-0cql96hu	25	26	with	with	IN
cord-281188-0cql96hu	25	27	bacteria	bacteria	NNS
cord-281188-0cql96hu	25	28	whose	whose	WP$
cord-281188-0cql96hu	25	29	viable	viable	JJ
cord-281188-0cql96hu	25	30	cell	cell	NN
cord-281188-0cql96hu	25	31	densities	density	NNS
cord-281188-0cql96hu	25	32	can	can	MD
cord-281188-0cql96hu	25	33	be	be	VB
cord-281188-0cql96hu	25	34	estimated	estimate	VBN
cord-281188-0cql96hu	25	35	from	from	IN
cord-281188-0cql96hu	25	36	data	datum	NNS
cord-281188-0cql96hu	25	37	on	on	IN
cord-281188-0cql96hu	25	38	colony	colony	NN
cord-281188-0cql96hu	25	39	-	-	HYPH
cord-281188-0cql96hu	25	40	forming	form	VBG
cord-281188-0cql96hu	25	41	units	unit	NNS
cord-281188-0cql96hu	25	42	,	,	,
cord-281188-0cql96hu	25	43	if	if	IN
cord-281188-0cql96hu	25	44	a	a	DT
cord-281188-0cql96hu	25	45	bacterium	bacterium	NN
cord-281188-0cql96hu	25	46	can	can	MD
cord-281188-0cql96hu	25	47	not	not	RB
cord-281188-0cql96hu	25	48	form	form	VB
cord-281188-0cql96hu	25	49	a	a	DT
cord-281188-0cql96hu	25	50	colony	colony	NN
cord-281188-0cql96hu	25	51	,	,	,
cord-281188-0cql96hu	25	52	it	-PRON-	PRP
cord-281188-0cql96hu	25	53	is	be	VBZ
cord-281188-0cql96hu	25	54	officially	officially	RB
cord-281188-0cql96hu	25	55	dead	dead	JJ
cord-281188-0cql96hu	25	56	.	.	.
cord-281188-0cql96hu	26	1	Deadly	deadly	JJ
cord-281188-0cql96hu	26	2	events	event	NNS
cord-281188-0cql96hu	26	3	are	be	VBP
cord-281188-0cql96hu	26	4	those	those	DT
cord-281188-0cql96hu	26	5	for	for	IN
cord-281188-0cql96hu	26	6	which	which	WDT
cord-281188-0cql96hu	26	7	the	the	DT
cord-281188-0cql96hu	26	8	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	26	9	agents	agent	NNS
cord-281188-0cql96hu	26	10	or	or	CC
cord-281188-0cql96hu	26	11	procedures	procedure	NNS
cord-281188-0cql96hu	26	12	immediately	immediately	RB
cord-281188-0cql96hu	26	13	destroy	destroy	VBP
cord-281188-0cql96hu	26	14	the	the	DT
cord-281188-0cql96hu	26	15	integrity	integrity	NN
cord-281188-0cql96hu	26	16	of	of	IN
cord-281188-0cql96hu	26	17	the	the	DT
cord-281188-0cql96hu	26	18	cell	cell	NN
cord-281188-0cql96hu	26	19	(	(	-LRB-
cord-281188-0cql96hu	26	20	similar	similar	JJ
cord-281188-0cql96hu	26	21	to	to	IN
cord-281188-0cql96hu	26	22	a	a	DT
cord-281188-0cql96hu	26	23	crash	crash	NN
cord-281188-0cql96hu	26	24	or	or	CC
cord-281188-0cql96hu	26	25	explosion	explosion	NN
cord-281188-0cql96hu	26	26	)	)	-RRB-
cord-281188-0cql96hu	26	27	,	,	,
cord-281188-0cql96hu	26	28	whereas	whereas	IN
cord-281188-0cql96hu	26	29	deadly	deadly	JJ
cord-281188-0cql96hu	26	30	processes	process	NNS
cord-281188-0cql96hu	26	31	resemble	resemble	VBP
cord-281188-0cql96hu	26	32	a	a	DT
cord-281188-0cql96hu	26	33	mortal	mortal	JJ
cord-281188-0cql96hu	26	34	illness	illness	NN
cord-281188-0cql96hu	26	35	(	(	-LRB-
cord-281188-0cql96hu	26	36	acute	acute	JJ
cord-281188-0cql96hu	26	37	or	or	CC
cord-281188-0cql96hu	26	38	chronic	chronic	JJ
cord-281188-0cql96hu	26	39	)	)	-RRB-
cord-281188-0cql96hu	26	40	,	,	,
cord-281188-0cql96hu	26	41	finally	finally	RB
cord-281188-0cql96hu	26	42	leading	lead	VBG
cord-281188-0cql96hu	26	43	to	to	IN
cord-281188-0cql96hu	26	44	the	the	DT
cord-281188-0cql96hu	26	45	collapse	collapse	NN
cord-281188-0cql96hu	26	46	of	of	IN
cord-281188-0cql96hu	26	47	physical	physical	JJ
cord-281188-0cql96hu	26	48	or	or	CC
cord-281188-0cql96hu	26	49	genetic	genetic	JJ
cord-281188-0cql96hu	26	50	individuality	individuality	NN
cord-281188-0cql96hu	26	51	.	.	.
cord-281188-0cql96hu	27	1	Probably	probably	RB
cord-281188-0cql96hu	27	2	,	,	,
cord-281188-0cql96hu	27	3	most	most	JJS
cord-281188-0cql96hu	27	4	of	of	IN
cord-281188-0cql96hu	27	5	the	the	DT
cord-281188-0cql96hu	27	6	deadly	deadly	JJ
cord-281188-0cql96hu	27	7	processes	process	NNS
cord-281188-0cql96hu	27	8	result	result	VBP
cord-281188-0cql96hu	27	9	from	from	IN
cord-281188-0cql96hu	27	10	the	the	DT
cord-281188-0cql96hu	27	11	antimicrobial	antimicrobial	RB
cord-281188-0cql96hu	27	12	-	-	HYPH
cord-281188-0cql96hu	27	13	induced	induce	VBN
cord-281188-0cql96hu	27	14	starvation	starvation	NN
cord-281188-0cql96hu	27	15	or	or	CC
cord-281188-0cql96hu	27	16	destruction	destruction	NN
cord-281188-0cql96hu	27	17	of	of	IN
cord-281188-0cql96hu	27	18	a	a	DT
cord-281188-0cql96hu	27	19	key	key	JJ
cord-281188-0cql96hu	27	20	cellular	cellular	JJ
cord-281188-0cql96hu	27	21	components	component	NNS
cord-281188-0cql96hu	27	22	needed	need	VBN
cord-281188-0cql96hu	27	23	to	to	TO
cord-281188-0cql96hu	27	24	maintain	maintain	VB
cord-281188-0cql96hu	27	25	the	the	DT
cord-281188-0cql96hu	27	26	cellular	cellular	JJ
cord-281188-0cql96hu	27	27	envelope	envelope	NN
cord-281188-0cql96hu	27	28	or	or	CC
cord-281188-0cql96hu	27	29	genetic	genetic	JJ
cord-281188-0cql96hu	27	30	integrity	integrity	NN
cord-281188-0cql96hu	27	31	.	.	.
cord-281188-0cql96hu	28	1	In	in	IN
cord-281188-0cql96hu	28	2	this	this	DT
cord-281188-0cql96hu	28	3	way	way	NN
cord-281188-0cql96hu	28	4	,	,	,
cord-281188-0cql96hu	28	5	an	an	DT
cord-281188-0cql96hu	28	6	antimicrobial	antimicrobial	NN
cord-281188-0cql96hu	28	7	,	,	,
cord-281188-0cql96hu	28	8	including	include	VBG
cord-281188-0cql96hu	28	9	chemical	chemical	JJ
cord-281188-0cql96hu	28	10	disinfectants	disinfectant	NNS
cord-281188-0cql96hu	28	11	,	,	,
cord-281188-0cql96hu	28	12	could	could	MD
cord-281188-0cql96hu	28	13	produce	produce	VB
cord-281188-0cql96hu	28	14	virtually	virtually	RB
cord-281188-0cql96hu	28	15	immediate	immediate	JJ
cord-281188-0cql96hu	28	16	death	death	NN
cord-281188-0cql96hu	28	17	of	of	IN
cord-281188-0cql96hu	28	18	a	a	DT
cord-281188-0cql96hu	28	19	bacterium	bacterium	NN
cord-281188-0cql96hu	28	20	at	at	IN
cord-281188-0cql96hu	28	21	higher	high	JJR
cord-281188-0cql96hu	28	22	concentrations	concentration	NNS
cord-281188-0cql96hu	28	23	and	and	CC
cord-281188-0cql96hu	28	24	at	at	IN
cord-281188-0cql96hu	28	25	lower	low	JJR
cord-281188-0cql96hu	28	26	concentrations	concentration	NNS
cord-281188-0cql96hu	28	27	could	could	MD
cord-281188-0cql96hu	28	28	produce	produce	VB
cord-281188-0cql96hu	28	29	morbidity	morbidity	NN
cord-281188-0cql96hu	28	30	and	and	CC
cord-281188-0cql96hu	28	31	a	a	DT
cord-281188-0cql96hu	28	32	slow	slow	JJ
cord-281188-0cql96hu	28	33	approach	approach	NN
cord-281188-0cql96hu	28	34	to	to	IN
cord-281188-0cql96hu	28	35	death	death	NN
cord-281188-0cql96hu	28	36	.	.	.
cord-281188-0cql96hu	29	1	Chlorine	chlorine	NN
cord-281188-0cql96hu	29	2	and	and	CC
cord-281188-0cql96hu	29	3	its	-PRON-	PRP$
cord-281188-0cql96hu	29	4	effects	effect	NNS
cord-281188-0cql96hu	29	5	on	on	IN
cord-281188-0cql96hu	29	6	the	the	DT
cord-281188-0cql96hu	29	7	membranes	membrane	NNS
cord-281188-0cql96hu	29	8	of	of	IN
cord-281188-0cql96hu	29	9	bacteria	bacteria	NNS
cord-281188-0cql96hu	29	10	is	be	VBZ
cord-281188-0cql96hu	29	11	an	an	DT
cord-281188-0cql96hu	29	12	excellent	excellent	JJ
cord-281188-0cql96hu	29	13	example	example	NN
cord-281188-0cql96hu	29	14	of	of	IN
cord-281188-0cql96hu	29	15	this	this	DT
cord-281188-0cql96hu	29	16	8	8	CD
cord-281188-0cql96hu	29	17	,	,	,
cord-281188-0cql96hu	29	18	9	9	CD
cord-281188-0cql96hu	29	19	.	.	.
cord-281188-0cql96hu	30	1	One	one	CD
cord-281188-0cql96hu	30	2	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	30	3	,	,	,
cord-281188-0cql96hu	30	4	many	many	JJ
cord-281188-0cql96hu	30	5	actions	action	NNS
cord-281188-0cql96hu	30	6	Traditionally	traditionally	RB
cord-281188-0cql96hu	30	7	,	,	,
cord-281188-0cql96hu	30	8	in	in	IN
cord-281188-0cql96hu	30	9	vitro	vitro	FW
cord-281188-0cql96hu	30	10	studies	study	NNS
cord-281188-0cql96hu	30	11	of	of	IN
cord-281188-0cql96hu	30	12	bacteria	bacteria	NNS
cord-281188-0cql96hu	30	13	and	and	CC
cord-281188-0cql96hu	30	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	30	15	ignore	ignore	VBP
cord-281188-0cql96hu	30	16	the	the	DT
cord-281188-0cql96hu	30	17	inconvenient	inconvenient	JJ
cord-281188-0cql96hu	30	18	reality	reality	NN
cord-281188-0cql96hu	30	19	of	of	IN
cord-281188-0cql96hu	30	20	the	the	DT
cord-281188-0cql96hu	30	21	physical	physical	JJ
cord-281188-0cql96hu	30	22	and	and	CC
cord-281188-0cql96hu	30	23	temporal	temporal	JJ
cord-281188-0cql96hu	30	24	heterogeneity	heterogeneity	NN
cord-281188-0cql96hu	30	25	of	of	IN
cord-281188-0cql96hu	30	26	bacterial	bacterial	JJ
cord-281188-0cql96hu	30	27	populations	population	NNS
cord-281188-0cql96hu	30	28	and	and	CC
cord-281188-0cql96hu	30	29	their	-PRON-	PRP$
cord-281188-0cql96hu	30	30	interactions	interaction	NNS
cord-281188-0cql96hu	30	31	with	with	IN
cord-281188-0cql96hu	30	32	these	these	DT
cord-281188-0cql96hu	30	33	drugs	drug	NNS
cord-281188-0cql96hu	30	34	.	.	.
cord-281188-0cql96hu	31	1	However	however	RB
cord-281188-0cql96hu	31	2	,	,	,
cord-281188-0cql96hu	31	3	it	-PRON-	PRP
cord-281188-0cql96hu	31	4	is	be	VBZ
cord-281188-0cql96hu	31	5	clear	clear	JJ
cord-281188-0cql96hu	31	6	that	that	IN
cord-281188-0cql96hu	31	7	for	for	IN
cord-281188-0cql96hu	31	8	a	a	DT
cord-281188-0cql96hu	31	9	comprehensive	comprehensive	JJ
cord-281188-0cql96hu	31	10	understanding	understanding	NN
cord-281188-0cql96hu	31	11	of	of	IN
cord-281188-0cql96hu	31	12	how	how	WRB
cord-281188-0cql96hu	31	13	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	31	14	do	do	VBP
cord-281188-0cql96hu	31	15	their	-PRON-	PRP$
cord-281188-0cql96hu	31	16	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	31	17	and	and	CC
cord-281188-0cql96hu	31	18	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	31	19	actions	action	NNS
cord-281188-0cql96hu	31	20	,	,	,
cord-281188-0cql96hu	31	21	this	this	DT
cord-281188-0cql96hu	31	22	complexity	complexity	NN
cord-281188-0cql96hu	31	23	must	must	MD
cord-281188-0cql96hu	31	24	be	be	VB
cord-281188-0cql96hu	31	25	considered	consider	VBN
cord-281188-0cql96hu	31	26	,	,	,
cord-281188-0cql96hu	31	27	but	but	CC
cord-281188-0cql96hu	31	28	rarely	rarely	RB
cord-281188-0cql96hu	31	29	is	be	VBZ
cord-281188-0cql96hu	31	30	.	.	.
cord-281188-0cql96hu	32	1	For	for	IN
cord-281188-0cql96hu	32	2	convenience	convenience	NN
cord-281188-0cql96hu	32	3	and	and	CC
cord-281188-0cql96hu	32	4	the	the	DT
cord-281188-0cql96hu	32	5	parametric	parametric	JJ
cord-281188-0cql96hu	32	6	reductionism	reductionism	NN
cord-281188-0cql96hu	32	7	manifest	manifest	VBP
cord-281188-0cql96hu	32	8	in	in	IN
cord-281188-0cql96hu	32	9	so	so	RB
cord-281188-0cql96hu	32	10	much	much	JJ
cord-281188-0cql96hu	32	11	of	of	IN
cord-281188-0cql96hu	32	12	biology	biology	NN
cord-281188-0cql96hu	32	13	,	,	,
cord-281188-0cql96hu	32	14	the	the	DT
cord-281188-0cql96hu	32	15	study	study	NN
cord-281188-0cql96hu	32	16	of	of	IN
cord-281188-0cql96hu	32	17	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	32	18	action	action	NN
cord-281188-0cql96hu	32	19	is	be	VBZ
cord-281188-0cql96hu	32	20	treated	treat	VBN
cord-281188-0cql96hu	32	21	as	as	IN
cord-281188-0cql96hu	32	22	a	a	DT
cord-281188-0cql96hu	32	23	static	static	JJ
cord-281188-0cql96hu	32	24	process	process	NN
cord-281188-0cql96hu	32	25	´	´	CD
cord-281188-0cql96hu	32	26	,	,	,
cord-281188-0cql96hu	32	27	and	and	CC
cord-281188-0cql96hu	32	28	the	the	DT
cord-281188-0cql96hu	32	29	use	use	NN
cord-281188-0cql96hu	32	30	of	of	IN
cord-281188-0cql96hu	32	31	minimum	minimum	JJ
cord-281188-0cql96hu	32	32	inhibitory	inhibitory	JJ
cord-281188-0cql96hu	32	33	concentrations	concentration	NNS
cord-281188-0cql96hu	32	34	as	as	IN
cord-281188-0cql96hu	32	35	the	the	DT
cord-281188-0cql96hu	32	36	unique	unique	JJ
cord-281188-0cql96hu	32	37	pharmacodynamic	pharmacodynamic	JJ
cord-281188-0cql96hu	32	38	parameter	parameter	NN
cord-281188-0cql96hu	32	39	is	be	VBZ
cord-281188-0cql96hu	32	40	reflection	reflection	NN
cord-281188-0cql96hu	32	41	of	of	IN
cord-281188-0cql96hu	32	42	this	this	DT
cord-281188-0cql96hu	32	43	approach	approach	NN
cord-281188-0cql96hu	32	44	10	10	CD
cord-281188-0cql96hu	32	45	.	.	.
cord-281188-0cql96hu	33	1	The	the	DT
cord-281188-0cql96hu	33	2	interaction	interaction	NN
cord-281188-0cql96hu	33	3	natural	natural	JJ
cord-281188-0cql96hu	33	4	selection	selection	NN
cord-281188-0cql96hu	33	5	or	or	CC
cord-281188-0cql96hu	33	6	evolution	evolution	NN
cord-281188-0cql96hu	33	7	)	)	-RRB-
cord-281188-0cql96hu	33	8	.	.	.
cord-281188-0cql96hu	34	1	We	-PRON-	PRP
cord-281188-0cql96hu	34	2	use	use	VBP
cord-281188-0cql96hu	34	3	these	these	DT
cord-281188-0cql96hu	34	4	terms	term	NNS
cord-281188-0cql96hu	34	5	similarly	similarly	RB
cord-281188-0cql96hu	34	6	to	to	TO
cord-281188-0cql96hu	34	7	respectively	respectively	RB
cord-281188-0cql96hu	34	8	refer	refer	VB
cord-281188-0cql96hu	34	9	to	to	IN
cord-281188-0cql96hu	34	10	the	the	DT
cord-281188-0cql96hu	34	11	primary	primary	JJ
cord-281188-0cql96hu	34	12	biochemical	biochemical	JJ
cord-281188-0cql96hu	34	13	mechanisms	mechanism	NNS
cord-281188-0cql96hu	34	14	by	by	IN
cord-281188-0cql96hu	34	15	which	which	WDT
cord-281188-0cql96hu	34	16	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	34	17	exert	exert	VBP
cord-281188-0cql96hu	34	18	their	-PRON-	PRP$
cord-281188-0cql96hu	34	19	action	action	NN
cord-281188-0cql96hu	34	20	(	(	-LRB-
cord-281188-0cql96hu	34	21	the	the	DT
cord-281188-0cql96hu	34	22	traditional	traditional	JJ
cord-281188-0cql96hu	34	23	'	'	''
cord-281188-0cql96hu	34	24	mechanisms	mechanism	NNS
cord-281188-0cql96hu	34	25	of	of	IN
cord-281188-0cql96hu	34	26	action	action	NN
cord-281188-0cql96hu	34	27	'	'	''
cord-281188-0cql96hu	34	28	)	)	-RRB-
cord-281188-0cql96hu	34	29	and	and	CC
cord-281188-0cql96hu	34	30	the	the	DT
cord-281188-0cql96hu	34	31	final	final	JJ
cord-281188-0cql96hu	34	32	result	result	NN
cord-281188-0cql96hu	34	33	of	of	IN
cord-281188-0cql96hu	34	34	the	the	DT
cord-281188-0cql96hu	34	35	process	process	NN
cord-281188-0cql96hu	35	1	(	(	-LRB-
cord-281188-0cql96hu	35	2	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	35	3	action).We	action).We	NNS
cord-281188-0cql96hu	35	4	know	know	VBP
cord-281188-0cql96hu	35	5	a	a	DT
cord-281188-0cql96hu	35	6	great	great	JJ
cord-281188-0cql96hu	35	7	deal	deal	NN
cord-281188-0cql96hu	35	8	about	about	IN
cord-281188-0cql96hu	35	9	the	the	DT
cord-281188-0cql96hu	35	10	proximate	proximate	JJ
cord-281188-0cql96hu	35	11	causes	cause	NNS
cord-281188-0cql96hu	35	12	of	of	IN
cord-281188-0cql96hu	35	13	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	35	14	action	action	NN
cord-281188-0cql96hu	35	15	,	,	,
cord-281188-0cql96hu	35	16	how	how	WRB
cord-281188-0cql96hu	35	17	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	35	18	interact	interact	VBP
cord-281188-0cql96hu	35	19	with	with	IN
cord-281188-0cql96hu	35	20	the	the	DT
cord-281188-0cql96hu	35	21	cell	cell	NN
cord-281188-0cql96hu	35	22	,	,	,
cord-281188-0cql96hu	35	23	but	but	CC
cord-281188-0cql96hu	35	24	we	-PRON-	PRP
cord-281188-0cql96hu	35	25	know	know	VBP
cord-281188-0cql96hu	35	26	vastly	vastly	RB
cord-281188-0cql96hu	35	27	less	less	JJR
cord-281188-0cql96hu	35	28	about	about	IN
cord-281188-0cql96hu	35	29	the	the	DT
cord-281188-0cql96hu	35	30	ultimate	ultimate	JJ
cord-281188-0cql96hu	35	31	causes	cause	NNS
cord-281188-0cql96hu	35	32	,	,	,
cord-281188-0cql96hu	35	33	why	why	WRB
cord-281188-0cql96hu	35	34	,	,	,
cord-281188-0cql96hu	35	35	when	when	WRB
cord-281188-0cql96hu	35	36	confronted	confront	VBN
cord-281188-0cql96hu	35	37	with	with	IN
cord-281188-0cql96hu	35	38	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	35	39	,	,	,
cord-281188-0cql96hu	35	40	bacteria	bacteria	NNS
cord-281188-0cql96hu	35	41	die	die	VBP
cord-281188-0cql96hu	35	42	,	,	,
cord-281188-0cql96hu	35	43	and	and	CC
cord-281188-0cql96hu	35	44	why	why	WRB
cord-281188-0cql96hu	35	45	they	-PRON-	PRP
cord-281188-0cql96hu	35	46	do	do	VBP
cord-281188-0cql96hu	35	47	so	so	RB
cord-281188-0cql96hu	35	48	at	at	IN
cord-281188-0cql96hu	35	49	different	different	JJ
cord-281188-0cql96hu	35	50	rates	rate	NNS
cord-281188-0cql96hu	35	51	.	.	.
cord-281188-0cql96hu	36	1	In	in	IN
cord-281188-0cql96hu	36	2	this	this	DT
cord-281188-0cql96hu	36	3	Perspective	perspective	NN
cord-281188-0cql96hu	36	4	,	,	,
cord-281188-0cql96hu	36	5	we	-PRON-	PRP
cord-281188-0cql96hu	36	6	consider	consider	VBP
cord-281188-0cql96hu	36	7	what	what	WP
cord-281188-0cql96hu	36	8	the	the	DT
cord-281188-0cql96hu	36	9	knowledge	knowledge	NN
cord-281188-0cql96hu	36	10	of	of	IN
cord-281188-0cql96hu	36	11	the	the	DT
cord-281188-0cql96hu	36	12	proximate	proximate	JJ
cord-281188-0cql96hu	36	13	causes	cause	NNS
cord-281188-0cql96hu	36	14	of	of	IN
cord-281188-0cql96hu	36	15	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	36	16	action	action	NN
cord-281188-0cql96hu	36	17	tells	tell	VBZ
cord-281188-0cql96hu	36	18	us	-PRON-	PRP
cord-281188-0cql96hu	36	19	about	about	IN
cord-281188-0cql96hu	36	20	these	these	DT
cord-281188-0cql96hu	36	21	ultimate	ultimate	JJ
cord-281188-0cql96hu	36	22	causes	cause	NNS
cord-281188-0cql96hu	36	23	,	,	,
cord-281188-0cql96hu	36	24	and	and	CC
cord-281188-0cql96hu	36	25	what	what	WP
cord-281188-0cql96hu	36	26	we	-PRON-	PRP
cord-281188-0cql96hu	36	27	know	know	VBP
cord-281188-0cql96hu	36	28	and	and	CC
cord-281188-0cql96hu	36	29	need	need	VBP
cord-281188-0cql96hu	36	30	to	to	TO
cord-281188-0cql96hu	36	31	know	know	VB
cord-281188-0cql96hu	36	32	to	to	TO
cord-281188-0cql96hu	36	33	truly	truly	RB
cord-281188-0cql96hu	36	34	understand	understand	VB
cord-281188-0cql96hu	36	35	how	how	WRB
cord-281188-0cql96hu	36	36	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	36	37	kill	kill	VBP
cord-281188-0cql96hu	36	38	bacterial	bacterial	JJ
cord-281188-0cql96hu	36	39	cells	cell	NNS
cord-281188-0cql96hu	36	40	.	.	.
cord-281188-0cql96hu	37	1	We	-PRON-	PRP
cord-281188-0cql96hu	37	2	discuss	discuss	VBP
cord-281188-0cql96hu	37	3	these	these	DT
cord-281188-0cql96hu	37	4	processes	process	NNS
cord-281188-0cql96hu	37	5	in	in	IN
cord-281188-0cql96hu	37	6	general	general	JJ
cord-281188-0cql96hu	37	7	and	and	CC
cord-281188-0cql96hu	37	8	for	for	IN
cord-281188-0cql96hu	37	9	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	37	10	of	of	IN
cord-281188-0cql96hu	37	11	specific	specific	JJ
cord-281188-0cql96hu	37	12	classes	class	NNS
cord-281188-0cql96hu	37	13	.	.	.
cord-281188-0cql96hu	38	1	When	when	WRB
cord-281188-0cql96hu	38	2	is	be	VBZ
cord-281188-0cql96hu	38	3	a	a	DT
cord-281188-0cql96hu	38	4	bacterium	bacterium	NN
cord-281188-0cql96hu	38	5	dead	dead	JJ
cord-281188-0cql96hu	38	6	?	?	.
cord-281188-0cql96hu	39	1	Central	central	JJ
cord-281188-0cql96hu	39	2	to	to	IN
cord-281188-0cql96hu	39	3	understanding	understand	VBG
cord-281188-0cql96hu	39	4	how	how	WRB
cord-281188-0cql96hu	39	5	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	39	6	kill	kill	VBP
cord-281188-0cql96hu	39	7	or	or	CC
cord-281188-0cql96hu	39	8	prevent	prevent	VBP
cord-281188-0cql96hu	39	9	the	the	DT
cord-281188-0cql96hu	39	10	replication	replication	NN
cord-281188-0cql96hu	39	11	of	of	IN
cord-281188-0cql96hu	39	12	their	-PRON-	PRP$
cord-281188-0cql96hu	39	13	target	target	NN
cord-281188-0cql96hu	39	14	bacteria	bacteria	NNS
cord-281188-0cql96hu	39	15	is	be	VBZ
cord-281188-0cql96hu	39	16	knowing	know	VBG
cord-281188-0cql96hu	39	17	when	when	WRB
cord-281188-0cql96hu	39	18	a	a	DT
cord-281188-0cql96hu	39	19	bacterium	bacterium	NN
cord-281188-0cql96hu	39	20	is	be	VBZ
cord-281188-0cql96hu	39	21	dead	dead	JJ
cord-281188-0cql96hu	39	22	and	and	CC
cord-281188-0cql96hu	39	23	when	when	WRB
cord-281188-0cql96hu	39	24	it	-PRON-	PRP
cord-281188-0cql96hu	39	25	is	be	VBZ
cord-281188-0cql96hu	39	26	no	no	RB
cord-281188-0cql96hu	39	27	longer	long	RBR
cord-281188-0cql96hu	39	28	capable	capable	JJ
cord-281188-0cql96hu	39	29	of	of	IN
cord-281188-0cql96hu	39	30	dividing	divide	VBG
cord-281188-0cql96hu	39	31	.	.	.
cord-281188-0cql96hu	40	1	Whereas	whereas	IN
cord-281188-0cql96hu	40	2	the	the	DT
cord-281188-0cql96hu	40	3	former	former	JJ
cord-281188-0cql96hu	40	4	is	be	VBZ
cord-281188-0cql96hu	40	5	irreversible	irreversible	JJ
cord-281188-0cql96hu	40	6	,	,	,
cord-281188-0cql96hu	40	7	the	the	DT
cord-281188-0cql96hu	40	8	latter	latter	NN
cord-281188-0cql96hu	40	9	is	be	VBZ
cord-281188-0cql96hu	40	10	expected	expect	VBN
cord-281188-0cql96hu	40	11	to	to	TO
cord-281188-0cql96hu	40	12	be	be	VB
cord-281188-0cql96hu	40	13	transient	transient	JJ
cord-281188-0cql96hu	40	14	,	,	,
cord-281188-0cql96hu	40	15	but	but	CC
cord-281188-0cql96hu	40	16	if	if	IN
cord-281188-0cql96hu	40	17	cell	cell	NN
cord-281188-0cql96hu	40	18	division	division	NN
cord-281188-0cql96hu	40	19	is	be	VBZ
cord-281188-0cql96hu	40	20	prevented	prevent	VBN
cord-281188-0cql96hu	40	21	for	for	IN
cord-281188-0cql96hu	40	22	a	a	DT
cord-281188-0cql96hu	40	23	long	long	JJ
cord-281188-0cql96hu	40	24	time	time	NN
cord-281188-0cql96hu	40	25	,	,	,
cord-281188-0cql96hu	40	26	the	the	DT
cord-281188-0cql96hu	40	27	bacterium	bacterium	NN
cord-281188-0cql96hu	40	28	is	be	VBZ
cord-281188-0cql96hu	40	29	effectively	effectively	RB
cord-281188-0cql96hu	40	30	dead	dead	JJ
cord-281188-0cql96hu	40	31	between	between	IN
cord-281188-0cql96hu	40	32	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	40	33	and	and	CC
cord-281188-0cql96hu	40	34	their	-PRON-	PRP$
cord-281188-0cql96hu	40	35	target	target	NN
cord-281188-0cql96hu	40	36	bacteria	bacteria	NNS
cord-281188-0cql96hu	40	37	is	be	VBZ
cord-281188-0cql96hu	40	38	a	a	DT
cord-281188-0cql96hu	40	39	dynamic	dynamic	JJ
cord-281188-0cql96hu	40	40	process	process	NN
cord-281188-0cql96hu	40	41	.	.	.
cord-281188-0cql96hu	41	1	Bacteria	Bacteria	NNS
cord-281188-0cql96hu	41	2	are	be	VBP
cord-281188-0cql96hu	41	3	in	in	IN
cord-281188-0cql96hu	41	4	a	a	DT
cord-281188-0cql96hu	41	5	continuous	continuous	JJ
cord-281188-0cql96hu	41	6	state	state	NN
cord-281188-0cql96hu	41	7	of	of	IN
cord-281188-0cql96hu	41	8	flux	flux	NN
cord-281188-0cql96hu	41	9	:	:	:
cord-281188-0cql96hu	41	10	their	-PRON-	PRP$
cord-281188-0cql96hu	41	11	populations	population	NNS
cord-281188-0cql96hu	41	12	are	be	VBP
cord-281188-0cql96hu	41	13	heterogeneous	heterogeneous	JJ
cord-281188-0cql96hu	41	14	and	and	CC
cord-281188-0cql96hu	41	15	composed	compose	VBN
cord-281188-0cql96hu	41	16	of	of	IN
cord-281188-0cql96hu	41	17	cells	cell	NNS
cord-281188-0cql96hu	41	18	of	of	IN
cord-281188-0cql96hu	41	19	a	a	DT
cord-281188-0cql96hu	41	20	diversity	diversity	NN
cord-281188-0cql96hu	41	21	of	of	IN
cord-281188-0cql96hu	41	22	ages	age	NNS
cord-281188-0cql96hu	41	23	(	(	-LRB-
cord-281188-0cql96hu	41	24	corresponding	correspond	VBG
cord-281188-0cql96hu	41	25	to	to	IN
cord-281188-0cql96hu	41	26	the	the	DT
cord-281188-0cql96hu	41	27	time	time	NN
cord-281188-0cql96hu	41	28	since	since	IN
cord-281188-0cql96hu	41	29	they	-PRON-	PRP
cord-281188-0cql96hu	41	30	were	be	VBD
cord-281188-0cql96hu	41	31	produced	produce	VBN
cord-281188-0cql96hu	41	32	by	by	IN
cord-281188-0cql96hu	41	33	cell	cell	NN
cord-281188-0cql96hu	41	34	division	division	NN
cord-281188-0cql96hu	41	35	)	)	-RRB-
cord-281188-0cql96hu	41	36	and	and	CC
cord-281188-0cql96hu	41	37	physiological	physiological	JJ
cord-281188-0cql96hu	41	38	states	state	NNS
cord-281188-0cql96hu	41	39	.	.	.
cord-281188-0cql96hu	42	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	42	2	act	act	VBP
cord-281188-0cql96hu	42	3	at	at	IN
cord-281188-0cql96hu	42	4	variable	variable	JJ
cord-281188-0cql96hu	42	5	concentrations	concentration	NNS
cord-281188-0cql96hu	42	6	,	,	,
cord-281188-0cql96hu	42	7	and	and	CC
cord-281188-0cql96hu	42	8	their	-PRON-	PRP$
cord-281188-0cql96hu	42	9	effects	effect	NNS
cord-281188-0cql96hu	42	10	on	on	IN
cord-281188-0cql96hu	42	11	bacteria	bacteria	NNS
cord-281188-0cql96hu	42	12	might	may	MD
cord-281188-0cql96hu	42	13	differ	differ	VB
cord-281188-0cql96hu	42	14	with	with	IN
cord-281188-0cql96hu	42	15	the	the	DT
cord-281188-0cql96hu	42	16	number	number	NN
cord-281188-0cql96hu	42	17	of	of	IN
cord-281188-0cql96hu	42	18	molecules	molecule	NNS
cord-281188-0cql96hu	42	19	effectively	effectively	RB
cord-281188-0cql96hu	42	20	interacting	interact	VBG
cord-281188-0cql96hu	42	21	with	with	IN
cord-281188-0cql96hu	42	22	each	each	DT
cord-281188-0cql96hu	42	23	cell	cell	NN
cord-281188-0cql96hu	42	24	.	.	.
cord-281188-0cql96hu	43	1	The	the	DT
cord-281188-0cql96hu	43	2	concept	concept	NN
cord-281188-0cql96hu	43	3	of	of	IN
cord-281188-0cql96hu	43	4	'	'	``
cord-281188-0cql96hu	43	5	hormesis	hormesis	NN
cord-281188-0cql96hu	43	6	'	'	''
cord-281188-0cql96hu	43	7	applies	applie	NNS
cord-281188-0cql96hu	43	8	here	here	RB
cord-281188-0cql96hu	43	9	.	.	.
cord-281188-0cql96hu	44	1	The	the	DT
cord-281188-0cql96hu	44	2	term	term	NN
cord-281188-0cql96hu	44	3	'	'	``
cord-281188-0cql96hu	44	4	hormesis	hormesis	NN
cord-281188-0cql96hu	44	5	'	'	''
cord-281188-0cql96hu	44	6	was	be	VBD
cord-281188-0cql96hu	44	7	coined	coin	VBN
cord-281188-0cql96hu	44	8	by	by	IN
cord-281188-0cql96hu	44	9	Southam	Southam	NNP
cord-281188-0cql96hu	44	10	and	and	CC
cord-281188-0cql96hu	44	11	Ehrlich	Ehrlich	NNP
cord-281188-0cql96hu	44	12	in	in	IN
cord-281188-0cql96hu	44	13	1943	1943	CD
cord-281188-0cql96hu	44	14	to	to	TO
cord-281188-0cql96hu	44	15	describe	describe	VB
cord-281188-0cql96hu	44	16	biphasic	biphasic	JJ
cord-281188-0cql96hu	44	17	dose	dose	NN
cord-281188-0cql96hu	44	18	responses	response	NNS
cord-281188-0cql96hu	44	19	of	of	IN
cord-281188-0cql96hu	44	20	the	the	DT
cord-281188-0cql96hu	44	21	same	same	JJ
cord-281188-0cql96hu	44	22	compound	compound	NN
cord-281188-0cql96hu	44	23	acting	act	VBG
cord-281188-0cql96hu	44	24	on	on	IN
cord-281188-0cql96hu	44	25	a	a	DT
cord-281188-0cql96hu	44	26	biological	biological	JJ
cord-281188-0cql96hu	44	27	substrate	substrate	NN
cord-281188-0cql96hu	44	28	11	11	CD
cord-281188-0cql96hu	44	29	.	.	.
cord-281188-0cql96hu	45	1	This	this	DT
cord-281188-0cql96hu	45	2	term	term	NN
cord-281188-0cql96hu	45	3	was	be	VBD
cord-281188-0cql96hu	45	4	resurrected	resurrect	VBN
cord-281188-0cql96hu	45	5	by	by	IN
cord-281188-0cql96hu	45	6	Julian	Julian	NNP
cord-281188-0cql96hu	45	7	Davies	Davies	NNP
cord-281188-0cql96hu	45	8	in	in	IN
cord-281188-0cql96hu	45	9	reference	reference	NN
cord-281188-0cql96hu	45	10	to	to	IN
cord-281188-0cql96hu	45	11	different	different	JJ
cord-281188-0cql96hu	45	12	types	type	NNS
cord-281188-0cql96hu	45	13	of	of	IN
cord-281188-0cql96hu	45	14	action	action	NN
cord-281188-0cql96hu	45	15	at	at	IN
cord-281188-0cql96hu	45	16	different	different	JJ
cord-281188-0cql96hu	45	17	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	45	18	concentrations	concentration	NNS
cord-281188-0cql96hu	45	19	,	,	,
cord-281188-0cql96hu	45	20	ranging	range	VBG
cord-281188-0cql96hu	45	21	from	from	IN
cord-281188-0cql96hu	45	22	promoting	promote	VBG
cord-281188-0cql96hu	45	23	death	death	NN
cord-281188-0cql96hu	45	24	to	to	IN
cord-281188-0cql96hu	45	25	serving	serve	VBG
cord-281188-0cql96hu	45	26	as	as	IN
cord-281188-0cql96hu	45	27	signals	signal	NNS
cord-281188-0cql96hu	45	28	in	in	IN
cord-281188-0cql96hu	45	29	interbacterial	interbacterial	JJ
cord-281188-0cql96hu	45	30	communication	communication	NN
cord-281188-0cql96hu	45	31	12	12	CD
cord-281188-0cql96hu	45	32	,	,	,
cord-281188-0cql96hu	45	33	13	13	CD
cord-281188-0cql96hu	45	34	.	.	.
cord-281188-0cql96hu	46	1	Hormesis	Hormesis	NNP
cord-281188-0cql96hu	46	2	is	be	VBZ
cord-281188-0cql96hu	46	3	considered	consider	VBN
cord-281188-0cql96hu	46	4	a	a	DT
cord-281188-0cql96hu	46	5	fundamental	fundamental	JJ
cord-281188-0cql96hu	46	6	concept	concept	NN
cord-281188-0cql96hu	46	7	in	in	IN
cord-281188-0cql96hu	46	8	medicine	medicine	NN
cord-281188-0cql96hu	46	9	and	and	CC
cord-281188-0cql96hu	46	10	biology	biology	NN
cord-281188-0cql96hu	46	11	14	14	CD
cord-281188-0cql96hu	46	12	,	,	,
cord-281188-0cql96hu	46	13	15	15	CD
cord-281188-0cql96hu	46	14	.	.	.
cord-281188-0cql96hu	47	1	Hormesis	Hormesis	NNP
cord-281188-0cql96hu	47	2	and	and	CC
cord-281188-0cql96hu	47	3	,	,	,
cord-281188-0cql96hu	47	4	more	more	RBR
cord-281188-0cql96hu	47	5	generally	generally	RB
cord-281188-0cql96hu	47	6	,	,	,
cord-281188-0cql96hu	47	7	multiphasic	multiphasic	JJ
cord-281188-0cql96hu	47	8	processes	process	NNS
cord-281188-0cql96hu	47	9	are	be	VBP
cord-281188-0cql96hu	47	10	certainly	certainly	RB
cord-281188-0cql96hu	47	11	a	a	DT
cord-281188-0cql96hu	47	12	reality	reality	NN
cord-281188-0cql96hu	47	13	for	for	IN
cord-281188-0cql96hu	47	14	the	the	DT
cord-281188-0cql96hu	47	15	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	47	16	treatment	treatment	NN
cord-281188-0cql96hu	47	17	of	of	IN
cord-281188-0cql96hu	47	18	bacterial	bacterial	JJ
cord-281188-0cql96hu	47	19	infections	infection	NNS
cord-281188-0cql96hu	47	20	.	.	.
cord-281188-0cql96hu	48	1	In	in	IN
cord-281188-0cql96hu	48	2	treated	treat	VBN
cord-281188-0cql96hu	48	3	patients	patient	NNS
cord-281188-0cql96hu	48	4	,	,	,
cord-281188-0cql96hu	48	5	the	the	DT
cord-281188-0cql96hu	48	6	concentrations	concentration	NNS
cord-281188-0cql96hu	48	7	of	of	IN
cord-281188-0cql96hu	48	8	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	48	9	vary	vary	VBP
cord-281188-0cql96hu	48	10	in	in	IN
cord-281188-0cql96hu	48	11	time	time	NN
cord-281188-0cql96hu	48	12	and	and	CC
cord-281188-0cql96hu	48	13	space	space	NN
cord-281188-0cql96hu	48	14	(	(	-LRB-
cord-281188-0cql96hu	48	15	intracellular	intracellular	JJ
cord-281188-0cql96hu	48	16	,	,	,
cord-281188-0cql96hu	48	17	tissues	tissue	NNS
cord-281188-0cql96hu	48	18	or	or	CC
cord-281188-0cql96hu	48	19	organic	organic	JJ
cord-281188-0cql96hu	48	20	fluids	fluid	NNS
cord-281188-0cql96hu	48	21	)	)	-RRB-
cord-281188-0cql96hu	48	22	;	;	:
cord-281188-0cql96hu	48	23	pharmacokinetics	pharmacokinetics	NNP
cord-281188-0cql96hu	48	24	is	be	VBZ
cord-281188-0cql96hu	48	25	a	a	DT
cord-281188-0cql96hu	48	26	highly	highly	RB
cord-281188-0cql96hu	48	27	dynamic	dynamic	JJ
cord-281188-0cql96hu	48	28	process	process	NN
cord-281188-0cql96hu	48	29	.	.	.
cord-281188-0cql96hu	49	1	The	the	DT
cord-281188-0cql96hu	49	2	individual	individual	JJ
cord-281188-0cql96hu	49	3	cells	cell	NNS
cord-281188-0cql96hu	49	4	of	of	IN
cord-281188-0cql96hu	49	5	the	the	DT
cord-281188-0cql96hu	49	6	target	target	NN
cord-281188-0cql96hu	49	7	bacteria	bacteria	NNS
cord-281188-0cql96hu	49	8	are	be	VBP
cord-281188-0cql96hu	49	9	confronted	confront	VBN
cord-281188-0cql96hu	49	10	with	with	IN
cord-281188-0cql96hu	49	11	variable	variable	JJ
cord-281188-0cql96hu	49	12	concentrations	concentration	NNS
cord-281188-0cql96hu	49	13	of	of	IN
cord-281188-0cql96hu	49	14	the	the	DT
cord-281188-0cql96hu	49	15	treating	treat	VBG
cord-281188-0cql96hu	49	16	drug	drug	NN
cord-281188-0cql96hu	49	17	,	,	,
cord-281188-0cql96hu	49	18	which	which	WDT
cord-281188-0cql96hu	49	19	has	have	VBZ
cord-281188-0cql96hu	49	20	different	different	JJ
cord-281188-0cql96hu	49	21	but	but	CC
cord-281188-0cql96hu	49	22	overlapping	overlapping	JJ
cord-281188-0cql96hu	49	23	effects	effect	NNS
cord-281188-0cql96hu	49	24	on	on	IN
cord-281188-0cql96hu	49	25	their	-PRON-	PRP$
cord-281188-0cql96hu	49	26	physiology	physiology	NN
cord-281188-0cql96hu	49	27	.	.	.
cord-281188-0cql96hu	50	1	Antibiotic	antibiotic	JJ
cord-281188-0cql96hu	50	2	susceptibility	susceptibility	NN
cord-281188-0cql96hu	50	3	tests	test	NNS
cord-281188-0cql96hu	50	4	based	base	VBN
cord-281188-0cql96hu	50	5	on	on	IN
cord-281188-0cql96hu	50	6	agar	agar	NNP
cord-281188-0cql96hu	50	7	diffusion	diffusion	NN
cord-281188-0cql96hu	50	8	or	or	CC
cord-281188-0cql96hu	50	9	the	the	DT
cord-281188-0cql96hu	50	10	response	response	NN
cord-281188-0cql96hu	50	11	of	of	IN
cord-281188-0cql96hu	50	12	bacteria	bacteria	NNS
cord-281188-0cql96hu	50	13	to	to	IN
cord-281188-0cql96hu	50	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	50	15	in	in	IN
cord-281188-0cql96hu	50	16	continuous	continuous	JJ
cord-281188-0cql96hu	50	17	culture	culture	NN
cord-281188-0cql96hu	50	18	16	16	CD
cord-281188-0cql96hu	50	19	offer	offer	VBP
cord-281188-0cql96hu	50	20	a	a	DT
cord-281188-0cql96hu	50	21	more	more	RBR
cord-281188-0cql96hu	50	22	realistic	realistic	JJ
cord-281188-0cql96hu	50	23	view	view	NN
cord-281188-0cql96hu	50	24	of	of	IN
cord-281188-0cql96hu	50	25	the	the	DT
cord-281188-0cql96hu	50	26	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	50	27	action	action	NN
cord-281188-0cql96hu	50	28	than	than	IN
cord-281188-0cql96hu	50	29	the	the	DT
cord-281188-0cql96hu	50	30	gold	gold	NN
cord-281188-0cql96hu	50	31	standard	standard	NN
cord-281188-0cql96hu	50	32	of	of	IN
cord-281188-0cql96hu	50	33	estimating	estimate	VBG
cord-281188-0cql96hu	50	34	the	the	DT
cord-281188-0cql96hu	50	35	minimum	minimum	JJ
cord-281188-0cql96hu	50	36	concentration	concentration	NN
cord-281188-0cql96hu	50	37	of	of	IN
cord-281188-0cql96hu	50	38	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	50	39	necessary	necessary	JJ
cord-281188-0cql96hu	50	40	to	to	TO
cord-281188-0cql96hu	50	41	prevent	prevent	VB
cord-281188-0cql96hu	50	42	replication	replication	NN
cord-281188-0cql96hu	50	43	(	(	-LRB-
cord-281188-0cql96hu	50	44	the	the	DT
cord-281188-0cql96hu	50	45	minimum	minimum	JJ
cord-281188-0cql96hu	50	46	inhibitory	inhibitory	JJ
cord-281188-0cql96hu	50	47	concentration	concentration	NN
cord-281188-0cql96hu	50	48	)	)	-RRB-
cord-281188-0cql96hu	50	49	by	by	IN
cord-281188-0cql96hu	50	50	exposing	expose	VBG
cord-281188-0cql96hu	50	51	well	well	RB
cord-281188-0cql96hu	50	52	-	-	HYPH
cord-281188-0cql96hu	50	53	mixed	mix	VBN
cord-281188-0cql96hu	50	54	bacterial	bacterial	JJ
cord-281188-0cql96hu	50	55	populations	population	NNS
cord-281188-0cql96hu	50	56	at	at	IN
cord-281188-0cql96hu	50	57	relatively	relatively	RB
cord-281188-0cql96hu	50	58	low	low	JJ
cord-281188-0cql96hu	50	59	densities	density	NNS
cord-281188-0cql96hu	50	60	growing	grow	VBG
cord-281188-0cql96hu	50	61	exponentially	exponentially	RB
cord-281188-0cql96hu	50	62	to	to	IN
cord-281188-0cql96hu	50	63	fixed	fix	VBN
cord-281188-0cql96hu	50	64	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	50	65	concentrations	concentration	NNS
cord-281188-0cql96hu	50	66	.	.	.
cord-281188-0cql96hu	51	1	We	-PRON-	PRP
cord-281188-0cql96hu	51	2	have	have	VBP
cord-281188-0cql96hu	51	3	considered	consider	VBN
cord-281188-0cql96hu	51	4	hormesis	hormesis	NN
cord-281188-0cql96hu	51	5	for	for	IN
cord-281188-0cql96hu	51	6	individual	individual	JJ
cord-281188-0cql96hu	51	7	cells	cell	NNS
cord-281188-0cql96hu	51	8	,	,	,
cord-281188-0cql96hu	51	9	as	as	IN
cord-281188-0cql96hu	51	10	it	-PRON-	PRP
cord-281188-0cql96hu	51	11	should	should	MD
cord-281188-0cql96hu	51	12	be	be	VB
cord-281188-0cql96hu	51	13	.	.	.
cord-281188-0cql96hu	52	1	However	however	RB
cord-281188-0cql96hu	52	2	,	,	,
cord-281188-0cql96hu	52	3	the	the	DT
cord-281188-0cql96hu	52	4	consequences	consequence	NNS
cord-281188-0cql96hu	52	5	of	of	IN
cord-281188-0cql96hu	52	6	the	the	DT
cord-281188-0cql96hu	52	7	'	'	CD
cord-281188-0cql96hu	52	8	one	one	CD
cord-281188-0cql96hu	52	9	antibiotic	antibiotic	NN
cord-281188-0cql96hu	52	10	,	,	,
cord-281188-0cql96hu	52	11	many	many	JJ
cord-281188-0cql96hu	52	12	actions	action	NNS
cord-281188-0cql96hu	52	13	'	'	POS
cord-281188-0cql96hu	52	14	paradigm	paradigm	NN
cord-281188-0cql96hu	52	15	are	be	VBP
cord-281188-0cql96hu	52	16	particularly	particularly	RB
cord-281188-0cql96hu	52	17	relevant	relevant	JJ
cord-281188-0cql96hu	52	18	in	in	IN
cord-281188-0cql96hu	52	19	assays	assay	NNS
cord-281188-0cql96hu	52	20	to	to	TO
cord-281188-0cql96hu	52	21	determine	determine	VB
cord-281188-0cql96hu	52	22	killing	kill	VBG
cord-281188-0cql96hu	52	23	curves	curve	NNS
cord-281188-0cql96hu	52	24	,	,	,
cord-281188-0cql96hu	52	25	which	which	WDT
cord-281188-0cql96hu	52	26	are	be	VBP
cord-281188-0cql96hu	52	27	normally	normally	RB
cord-281188-0cql96hu	52	28	performed	perform	VBN
cord-281188-0cql96hu	52	29	on	on	IN
cord-281188-0cql96hu	52	30	relatively	relatively	RB
cord-281188-0cql96hu	52	31	dense	dense	JJ
cord-281188-0cql96hu	52	32	bacterial	bacterial	JJ
cord-281188-0cql96hu	52	33	populations	population	NNS
cord-281188-0cql96hu	52	34	(	(	-LRB-
cord-281188-0cql96hu	52	35	on	on	IN
cord-281188-0cql96hu	52	36	the	the	DT
cord-281188-0cql96hu	52	37	order	order	NN
cord-281188-0cql96hu	52	38	of	of	IN
cord-281188-0cql96hu	52	39	10	10	CD
cord-281188-0cql96hu	52	40	7	7	CD
cord-281188-0cql96hu	52	41	cells	cell	NNS
cord-281188-0cql96hu	52	42	per	per	IN
cord-281188-0cql96hu	52	43	millilitre	millilitre	NN
cord-281188-0cql96hu	52	44	)	)	-RRB-
cord-281188-0cql96hu	52	45	.	.	.
cord-281188-0cql96hu	53	1	Such	such	JJ
cord-281188-0cql96hu	53	2	high	high	JJ
cord-281188-0cql96hu	53	3	numbers	number	NNS
cord-281188-0cql96hu	53	4	ensure	ensure	VBP
cord-281188-0cql96hu	53	5	substantial	substantial	JJ
cord-281188-0cql96hu	53	6	heterogeneity	heterogeneity	NN
cord-281188-0cql96hu	53	7	in	in	IN
cord-281188-0cql96hu	53	8	the	the	DT
cord-281188-0cql96hu	53	9	physiological	physiological	JJ
cord-281188-0cql96hu	53	10	conditions	condition	NNS
cord-281188-0cql96hu	53	11	of	of	IN
cord-281188-0cql96hu	53	12	each	each	DT
cord-281188-0cql96hu	53	13	bacterial	bacterial	JJ
cord-281188-0cql96hu	53	14	cell	cell	NN
cord-281188-0cql96hu	53	15	,	,	,
cord-281188-0cql96hu	53	16	so	so	RB
cord-281188-0cql96hu	53	17	different	different	JJ
cord-281188-0cql96hu	53	18	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	53	19	actions	action	NNS
cord-281188-0cql96hu	53	20	are	be	VBP
cord-281188-0cql96hu	53	21	expected	expect	VBN
cord-281188-0cql96hu	53	22	to	to	TO
cord-281188-0cql96hu	53	23	apply	apply	VB
cord-281188-0cql96hu	53	24	in	in	IN
cord-281188-0cql96hu	53	25	a	a	DT
cord-281188-0cql96hu	53	26	population	population	NN
cord-281188-0cql96hu	53	27	of	of	IN
cord-281188-0cql96hu	53	28	cells	cell	NNS
cord-281188-0cql96hu	53	29	with	with	IN
cord-281188-0cql96hu	53	30	different	different	JJ
cord-281188-0cql96hu	53	31	ages	age	NNS
cord-281188-0cql96hu	53	32	and	and	CC
cord-281188-0cql96hu	53	33	physiological	physiological	JJ
cord-281188-0cql96hu	53	34	states	state	NNS
cord-281188-0cql96hu	53	35	.	.	.
cord-281188-0cql96hu	54	1	What	what	WP
cord-281188-0cql96hu	54	2	does	do	VBZ
cord-281188-0cql96hu	54	3	the	the	DT
cord-281188-0cql96hu	54	4	relationship	relationship	NN
cord-281188-0cql96hu	54	5	between	between	IN
cord-281188-0cql96hu	54	6	the	the	DT
cord-281188-0cql96hu	54	7	concentration	concentration	NN
cord-281188-0cql96hu	54	8	of	of	IN
cord-281188-0cql96hu	54	9	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	54	10	and	and	CC
cord-281188-0cql96hu	54	11	the	the	DT
cord-281188-0cql96hu	54	12	rate	rate	NN
cord-281188-0cql96hu	54	13	of	of	IN
cord-281188-0cql96hu	54	14	growth	growth	NN
cord-281188-0cql96hu	54	15	and	and	CC
cord-281188-0cql96hu	54	16	death	death	NN
cord-281188-0cql96hu	54	17	of	of	IN
cord-281188-0cql96hu	54	18	bacteria	bacteria	NNS
cord-281188-0cql96hu	54	19	(	(	-LRB-
cord-281188-0cql96hu	54	20	that	that	RB
cord-281188-0cql96hu	54	21	is	is	RB
cord-281188-0cql96hu	54	22	,	,	,
cord-281188-0cql96hu	54	23	pharmacodynamics	pharmacodynamic	NNS
cord-281188-0cql96hu	54	24	)	)	-RRB-
cord-281188-0cql96hu	54	25	tell	tell	VB
cord-281188-0cql96hu	54	26	us	-PRON-	PRP
cord-281188-0cql96hu	54	27	about	about	IN
cord-281188-0cql96hu	54	28	how	how	WRB
cord-281188-0cql96hu	54	29	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	54	30	do	do	VBP
cord-281188-0cql96hu	54	31	their	-PRON-	PRP$
cord-281188-0cql96hu	54	32	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	54	33	and	and	CC
cord-281188-0cql96hu	54	34	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	54	35	actions	action	NNS
cord-281188-0cql96hu	54	36	?	?	.
cord-281188-0cql96hu	55	1	As	as	IN
cord-281188-0cql96hu	55	2	can	can	MD
cord-281188-0cql96hu	55	3	be	be	VB
cord-281188-0cql96hu	55	4	seen	see	VBN
cord-281188-0cql96hu	55	5	in	in	IN
cord-281188-0cql96hu	55	6	fig	fig	NN
cord-281188-0cql96hu	55	7	.	.	.
cord-281188-0cql96hu	56	1	1	1	LS
cord-281188-0cql96hu	56	2	,	,	,
cord-281188-0cql96hu	56	3	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	56	4	differ	differ	VBP
cord-281188-0cql96hu	56	5	considerably	considerably	RB
cord-281188-0cql96hu	56	6	in	in	IN
cord-281188-0cql96hu	56	7	the	the	DT
cord-281188-0cql96hu	56	8	rates	rate	NNS
cord-281188-0cql96hu	56	9	at	at	IN
cord-281188-0cql96hu	56	10	which	which	WDT
cord-281188-0cql96hu	56	11	they	-PRON-	PRP
cord-281188-0cql96hu	56	12	kill	kill	VBP
cord-281188-0cql96hu	56	13	bacteria	bacteria	NNS
cord-281188-0cql96hu	56	14	.	.	.
cord-281188-0cql96hu	57	1	Although	although	IN
cord-281188-0cql96hu	57	2	the	the	DT
cord-281188-0cql96hu	57	3	drug	drug	NN
cord-281188-0cql96hu	57	4	dose	dose	NN
cord-281188-0cql96hu	57	5	,	,	,
cord-281188-0cql96hu	57	6	relative	relative	JJ
cord-281188-0cql96hu	57	7	to	to	IN
cord-281188-0cql96hu	57	8	the	the	DT
cord-281188-0cql96hu	57	9	minimum	minimum	JJ
cord-281188-0cql96hu	57	10	inhibitory	inhibitory	JJ
cord-281188-0cql96hu	57	11	concentration	concentration	NN
cord-281188-0cql96hu	57	12	,	,	,
cord-281188-0cql96hu	57	13	to	to	TO
cord-281188-0cql96hu	57	14	which	which	WDT
cord-281188-0cql96hu	57	15	these	these	DT
cord-281188-0cql96hu	57	16	growing	grow	VBG
cord-281188-0cql96hu	57	17	populations	population	NNS
cord-281188-0cql96hu	57	18	of	of	IN
cord-281188-0cql96hu	57	19	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	57	20	aureus	aureu	NNS
cord-281188-0cql96hu	57	21	are	be	VBP
cord-281188-0cql96hu	57	22	exposed	expose	VBN
cord-281188-0cql96hu	57	23	(	(	-LRB-
cord-281188-0cql96hu	57	24	10	10	CD
cord-281188-0cql96hu	57	25	times	time	NNS
cord-281188-0cql96hu	57	26	the	the	DT
cord-281188-0cql96hu	57	27	minimum	minimum	JJ
cord-281188-0cql96hu	57	28	inhibitory	inhibitory	JJ
cord-281188-0cql96hu	57	29	concentration	concentration	NN
cord-281188-0cql96hu	57	30	)	)	-RRB-
cord-281188-0cql96hu	57	31	is	be	VBZ
cord-281188-0cql96hu	57	32	the	the	DT
cord-281188-0cql96hu	57	33	same	same	JJ
cord-281188-0cql96hu	57	34	for	for	IN
cord-281188-0cql96hu	57	35	the	the	DT
cord-281188-0cql96hu	57	36	nine	nine	CD
cord-281188-0cql96hu	57	37	drugs	drug	NNS
cord-281188-0cql96hu	57	38	,	,	,
cord-281188-0cql96hu	57	39	the	the	DT
cord-281188-0cql96hu	57	40	rates	rate	NNS
cord-281188-0cql96hu	57	41	at	at	IN
cord-281188-0cql96hu	57	42	which	which	WDT
cord-281188-0cql96hu	57	43	the	the	DT
cord-281188-0cql96hu	57	44	viable	viable	JJ
cord-281188-0cql96hu	57	45	cell	cell	NN
cord-281188-0cql96hu	57	46	densities	density	NNS
cord-281188-0cql96hu	57	47	decline	decline	VBP
cord-281188-0cql96hu	57	48	(	(	-LRB-
cord-281188-0cql96hu	57	49	that	that	RB
cord-281188-0cql96hu	57	50	is	is	RB
cord-281188-0cql96hu	57	51	,	,	,
cord-281188-0cql96hu	57	52	the	the	DT
cord-281188-0cql96hu	57	53	raters	rater	NNS
cord-281188-0cql96hu	57	54	at	at	IN
cord-281188-0cql96hu	57	55	which	which	WDT
cord-281188-0cql96hu	57	56	the	the	DT
cord-281188-0cql96hu	57	57	bacteria	bacteria	NNS
cord-281188-0cql96hu	57	58	are	be	VBP
cord-281188-0cql96hu	57	59	killed	kill	VBN
cord-281188-0cql96hu	57	60	)	)	-RRB-
cord-281188-0cql96hu	57	61	differ	differ	VBP
cord-281188-0cql96hu	57	62	considerably	considerably	RB
cord-281188-0cql96hu	57	63	among	among	IN
cord-281188-0cql96hu	57	64	these	these	DT
cord-281188-0cql96hu	57	65	drugs	drug	NNS
cord-281188-0cql96hu	57	66	.	.	.
cord-281188-0cql96hu	58	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	58	2	that	that	WDT
cord-281188-0cql96hu	58	3	are	be	VBP
cord-281188-0cql96hu	58	4	deemed	deem	VBN
cord-281188-0cql96hu	58	5	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	58	6	kill	kill	NN
cord-281188-0cql96hu	58	7	at	at	IN
cord-281188-0cql96hu	58	8	low	low	JJ
cord-281188-0cql96hu	58	9	rates	rate	NNS
cord-281188-0cql96hu	58	10	,	,	,
cord-281188-0cql96hu	58	11	whereas	whereas	IN
cord-281188-0cql96hu	58	12	those	those	DT
cord-281188-0cql96hu	58	13	deemed	deem	VBN
cord-281188-0cql96hu	58	14	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	58	15	kill	kill	NN
cord-281188-0cql96hu	58	16	at	at	IN
cord-281188-0cql96hu	58	17	higher	high	JJR
cord-281188-0cql96hu	58	18	but	but	CC
cord-281188-0cql96hu	58	19	very	very	RB
cord-281188-0cql96hu	58	20	different	different	JJ
cord-281188-0cql96hu	58	21	rates	rate	NNS
cord-281188-0cql96hu	58	22	.	.	.
cord-281188-0cql96hu	59	1	The	the	DT
cord-281188-0cql96hu	59	2	rates	rate	NNS
cord-281188-0cql96hu	59	3	at	at	IN
cord-281188-0cql96hu	59	4	which	which	WDT
cord-281188-0cql96hu	59	5	oxacillin	oxacillin	NNP
cord-281188-0cql96hu	59	6	and	and	CC
cord-281188-0cql96hu	59	7	vancomycin	vancomycin	NN
cord-281188-0cql96hu	59	8	kill	kill	NN
cord-281188-0cql96hu	59	9	during	during	IN
cord-281188-0cql96hu	59	10	the	the	DT
cord-281188-0cql96hu	59	11	8	8	CD
cord-281188-0cql96hu	59	12	hours	hour	NNS
cord-281188-0cql96hu	59	13	of	of	IN
cord-281188-0cql96hu	59	14	the	the	DT
cord-281188-0cql96hu	59	15	experiment	experiment	NN
cord-281188-0cql96hu	59	16	are	be	VBP
cord-281188-0cql96hu	59	17	not	not	RB
cord-281188-0cql96hu	59	18	much	much	RB
cord-281188-0cql96hu	59	19	greater	great	JJR
cord-281188-0cql96hu	59	20	than	than	IN
cord-281188-0cql96hu	59	21	those	those	DT
cord-281188-0cql96hu	59	22	of	of	IN
cord-281188-0cql96hu	59	23	the	the	DT
cord-281188-0cql96hu	59	24	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	59	25	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	59	26	.	.	.
cord-281188-0cql96hu	60	1	The	the	DT
cord-281188-0cql96hu	60	2	rates	rate	NNS
cord-281188-0cql96hu	60	3	of	of	IN
cord-281188-0cql96hu	60	4	decline	decline	NN
cord-281188-0cql96hu	60	5	in	in	IN
cord-281188-0cql96hu	60	6	the	the	DT
cord-281188-0cql96hu	60	7	density	density	NN
cord-281188-0cql96hu	60	8	of	of	IN
cord-281188-0cql96hu	60	9	S.	S.	NNP
cord-281188-0cql96hu	60	10	aureus	aureus	NN
cord-281188-0cql96hu	60	11	exposed	expose	VBN
cord-281188-0cql96hu	60	12	to	to	IN
cord-281188-0cql96hu	60	13	gentamicin	gentamicin	NNP
cord-281188-0cql96hu	60	14	,	,	,
cord-281188-0cql96hu	60	15	daptomycin	daptomycin	NNS
cord-281188-0cql96hu	60	16	,	,	,
cord-281188-0cql96hu	60	17	ciprofloxacin	ciprofloxacin	NN
cord-281188-0cql96hu	60	18	and	and	CC
cord-281188-0cql96hu	60	19	rifampin	rifampin	NN
cord-281188-0cql96hu	60	20	are	be	VBP
cord-281188-0cql96hu	60	21	not	not	RB
cord-281188-0cql96hu	60	22	monotonic	monotonic	JJ
cord-281188-0cql96hu	60	23	.	.	.
cord-281188-0cql96hu	61	1	In	in	IN
cord-281188-0cql96hu	61	2	the	the	DT
cord-281188-0cql96hu	61	3	case	case	NN
cord-281188-0cql96hu	61	4	of	of	IN
cord-281188-0cql96hu	61	5	rifampin	rifampin	NN
cord-281188-0cql96hu	61	6	,	,	,
cord-281188-0cql96hu	61	7	resistant	resistant	JJ
cord-281188-0cql96hu	61	8	mutants	mutant	NNS
cord-281188-0cql96hu	61	9	emerged	emerge	VBD
cord-281188-0cql96hu	61	10	.	.	.
cord-281188-0cql96hu	62	1	For	for	IN
cord-281188-0cql96hu	62	2	the	the	DT
cord-281188-0cql96hu	62	3	other	other	JJ
cord-281188-0cql96hu	62	4	three	three	CD
cord-281188-0cql96hu	62	5	drugs	drug	NNS
cord-281188-0cql96hu	62	6	,	,	,
cord-281188-0cql96hu	62	7	there	there	EX
cord-281188-0cql96hu	62	8	is	be	VBZ
cord-281188-0cql96hu	62	9	a	a	DT
cord-281188-0cql96hu	62	10	levelling	levelling	NN
cord-281188-0cql96hu	62	11	off	off	RP
cord-281188-0cql96hu	62	12	in	in	IN
cord-281188-0cql96hu	62	13	the	the	DT
cord-281188-0cql96hu	62	14	kill	kill	NN
cord-281188-0cql96hu	62	15	rate	rate	NN
cord-281188-0cql96hu	62	16	,	,	,
cord-281188-0cql96hu	62	17	which	which	WDT
cord-281188-0cql96hu	62	18	can	can	MD
cord-281188-0cql96hu	62	19	be	be	VB
cord-281188-0cql96hu	62	20	attributed	attribute	VBN
cord-281188-0cql96hu	62	21	to	to	IN
cord-281188-0cql96hu	62	22	persistence	persistence	NN
cord-281188-0cql96hu	62	23	17	17	CD
cord-281188-0cql96hu	62	24	,	,	,
cord-281188-0cql96hu	62	25	18	18	CD
cord-281188-0cql96hu	62	26	.	.	.
cord-281188-0cql96hu	63	1	The	the	DT
cord-281188-0cql96hu	63	2	bacteria	bacteria	NNS
cord-281188-0cql96hu	63	3	recovered	recover	VBN
cord-281188-0cql96hu	63	4	from	from	IN
cord-281188-0cql96hu	63	5	these	these	DT
cord-281188-0cql96hu	63	6	time	time	NN
cord-281188-0cql96hu	63	7	-	-	HYPH
cord-281188-0cql96hu	63	8	kill	kill	NN
cord-281188-0cql96hu	63	9	experiments	experiment	NNS
cord-281188-0cql96hu	63	10	were	be	VBD
cord-281188-0cql96hu	63	11	as	as	RB
cord-281188-0cql96hu	63	12	susceptible	susceptible	JJ
cord-281188-0cql96hu	63	13	to	to	IN
cord-281188-0cql96hu	63	14	these	these	DT
cord-281188-0cql96hu	63	15	three	three	CD
cord-281188-0cql96hu	63	16	drugs	drug	NNS
cord-281188-0cql96hu	63	17	as	as	IN
cord-281188-0cql96hu	63	18	their	-PRON-	PRP$
cord-281188-0cql96hu	63	19	ancestors	ancestor	NNS
cord-281188-0cql96hu	63	20	used	use	VBD
cord-281188-0cql96hu	63	21	to	to	TO
cord-281188-0cql96hu	63	22	start	start	VB
cord-281188-0cql96hu	63	23	the	the	DT
cord-281188-0cql96hu	63	24	experiment	experiment	NN
cord-281188-0cql96hu	63	25	.	.	.
cord-281188-0cql96hu	64	1	There	there	EX
cord-281188-0cql96hu	64	2	are	be	VBP
cord-281188-0cql96hu	64	3	a	a	DT
cord-281188-0cql96hu	64	4	number	number	NN
cord-281188-0cql96hu	64	5	of	of	IN
cord-281188-0cql96hu	64	6	possible	possible	JJ
cord-281188-0cql96hu	64	7	,	,	,
cord-281188-0cql96hu	64	8	but	but	CC
cord-281188-0cql96hu	64	9	not	not	RB
cord-281188-0cql96hu	64	10	mutually	mutually	RB
cord-281188-0cql96hu	64	11	exclusive	exclusive	JJ
cord-281188-0cql96hu	64	12	,	,	,
cord-281188-0cql96hu	64	13	explanations	explanation	NNS
cord-281188-0cql96hu	64	14	for	for	IN
cord-281188-0cql96hu	64	15	these	these	DT
cord-281188-0cql96hu	64	16	differences	difference	NNS
cord-281188-0cql96hu	64	17	in	in	IN
cord-281188-0cql96hu	64	18	killing	kill	VBG
cord-281188-0cql96hu	64	19	rates	rate	NNS
cord-281188-0cql96hu	64	20	,	,	,
cord-281188-0cql96hu	64	21	which	which	WDT
cord-281188-0cql96hu	64	22	we	-PRON-	PRP
cord-281188-0cql96hu	64	23	illustrate	illustrate	VBP
cord-281188-0cql96hu	64	24	in	in	IN
cord-281188-0cql96hu	64	25	fig	fig	NN
cord-281188-0cql96hu	64	26	.	.	.
cord-281188-0cql96hu	65	1	2	2	LS
cord-281188-0cql96hu	65	2	.	.	.
cord-281188-0cql96hu	66	1	We	-PRON-	PRP
cord-281188-0cql96hu	66	2	believe	believe	VBP
cord-281188-0cql96hu	66	3	the	the	DT
cord-281188-0cql96hu	66	4	following	follow	VBG
cord-281188-0cql96hu	66	5	explanations	explanation	NNS
cord-281188-0cql96hu	66	6	to	to	TO
cord-281188-0cql96hu	66	7	be	be	VB
cord-281188-0cql96hu	66	8	particularly	particularly	RB
cord-281188-0cql96hu	66	9	relevant	relevant	JJ
cord-281188-0cql96hu	66	10	:	:	:
cord-281188-0cql96hu	66	11	(	(	-LRB-
cord-281188-0cql96hu	66	12	1	1	LS
cord-281188-0cql96hu	66	13	)	)	-RRB-
cord-281188-0cql96hu	66	14	only	only	RB
cord-281188-0cql96hu	66	15	free	free	JJ
cord-281188-0cql96hu	66	16	drug	drug	NN
cord-281188-0cql96hu	66	17	is	be	VBZ
cord-281188-0cql96hu	66	18	active	active	JJ
cord-281188-0cql96hu	66	19	against	against	IN
cord-281188-0cql96hu	66	20	the	the	DT
cord-281188-0cql96hu	66	21	target	target	NN
cord-281188-0cql96hu	66	22	bacteria	bacteria	NNS
cord-281188-0cql96hu	66	23	,	,	,
cord-281188-0cql96hu	66	24	and	and	CC
cord-281188-0cql96hu	66	25	protein	protein	NN
cord-281188-0cql96hu	66	26	binding	binding	NN
cord-281188-0cql96hu	66	27	of	of	IN
cord-281188-0cql96hu	66	28	the	the	DT
cord-281188-0cql96hu	66	29	drug	drug	NN
cord-281188-0cql96hu	66	30	decreases	decrease	VBZ
cord-281188-0cql96hu	66	31	the	the	DT
cord-281188-0cql96hu	66	32	rate	rate	NN
cord-281188-0cql96hu	66	33	of	of	IN
cord-281188-0cql96hu	66	34	killing	kill	VBG
cord-281188-0cql96hu	66	35	19	19	CD
cord-281188-0cql96hu	66	36	;	;	:
cord-281188-0cql96hu	66	37	(	(	-LRB-
cord-281188-0cql96hu	66	38	2	2	LS
cord-281188-0cql96hu	66	39	)	)	-RRB-
cord-281188-0cql96hu	66	40	there	there	EX
cord-281188-0cql96hu	66	41	are	be	VBP
cord-281188-0cql96hu	66	42	structures	structure	NNS
cord-281188-0cql96hu	66	43	(	(	-LRB-
cord-281188-0cql96hu	66	44	such	such	JJ
cord-281188-0cql96hu	66	45	as	as	IN
cord-281188-0cql96hu	66	46	porins	porins	NNP
cord-281188-0cql96hu	66	47	)	)	-RRB-
cord-281188-0cql96hu	66	48	and	and	CC
cord-281188-0cql96hu	66	49	mechanisms	mechanism	NNS
cord-281188-0cql96hu	66	50	facilitating	facilitate	VBG
cord-281188-0cql96hu	66	51	drug	drug	NN
cord-281188-0cql96hu	66	52	uptake	uptake	NN
cord-281188-0cql96hu	66	53	,	,	,
cord-281188-0cql96hu	66	54	but	but	CC
cord-281188-0cql96hu	66	55	also	also	RB
cord-281188-0cql96hu	66	56	barriers	barrier	NNS
cord-281188-0cql96hu	66	57	that	that	WDT
cord-281188-0cql96hu	66	58	prevent	prevent	VBP
cord-281188-0cql96hu	66	59	the	the	DT
cord-281188-0cql96hu	66	60	drug	drug	NN
cord-281188-0cql96hu	66	61	from	from	IN
cord-281188-0cql96hu	66	62	entering	enter	VBG
cord-281188-0cql96hu	66	63	the	the	DT
cord-281188-0cql96hu	66	64	cells	cell	NNS
cord-281188-0cql96hu	66	65	20	20	CD
cord-281188-0cql96hu	66	66	;	;	:
cord-281188-0cql96hu	66	67	(	(	-LRB-
cord-281188-0cql96hu	66	68	3	3	LS
cord-281188-0cql96hu	66	69	)	)	-RRB-
cord-281188-0cql96hu	66	70	the	the	DT
cord-281188-0cql96hu	66	71	drug	drug	NN
cord-281188-0cql96hu	66	72	can	can	MD
cord-281188-0cql96hu	66	73	be	be	VB
cord-281188-0cql96hu	66	74	pumped	pump	VBN
cord-281188-0cql96hu	66	75	out	out	RP
cord-281188-0cql96hu	66	76	,	,	,
cord-281188-0cql96hu	66	77	so	so	CC
cord-281188-0cql96hu	66	78	the	the	DT
cord-281188-0cql96hu	66	79	concentration	concentration	NN
cord-281188-0cql96hu	66	80	needed	need	VBN
cord-281188-0cql96hu	66	81	for	for	IN
cord-281188-0cql96hu	66	82	killing	killing	NN
cord-281188-0cql96hu	66	83	takes	take	VBZ
cord-281188-0cql96hu	66	84	longer	long	RBR
cord-281188-0cql96hu	66	85	to	to	TO
cord-281188-0cql96hu	66	86	achieve	achieve	VB
cord-281188-0cql96hu	66	87	21	21	CD
cord-281188-0cql96hu	66	88	,	,	,
cord-281188-0cql96hu	66	89	22	22	CD
cord-281188-0cql96hu	66	90	;	;	:
cord-281188-0cql96hu	66	91	(	(	-LRB-
cord-281188-0cql96hu	66	92	4	4	LS
cord-281188-0cql96hu	66	93	)	)	-RRB-
cord-281188-0cql96hu	66	94	the	the	DT
cord-281188-0cql96hu	66	95	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	66	96	with	with	IN
cord-281188-0cql96hu	66	97	weak	weak	JJ
cord-281188-0cql96hu	66	98	target	target	NN
cord-281188-0cql96hu	66	99	-	-	HYPH
cord-281188-0cql96hu	66	100	binding	bind	VBG
cord-281188-0cql96hu	66	101	affinity	affinity	NN
cord-281188-0cql96hu	66	102	will	will	MD
cord-281188-0cql96hu	66	103	take	take	VB
cord-281188-0cql96hu	66	104	longer	long	RBR
cord-281188-0cql96hu	66	105	to	to	TO
cord-281188-0cql96hu	66	106	achieve	achieve	VB
cord-281188-0cql96hu	66	107	the	the	DT
cord-281188-0cql96hu	66	108	doses	dose	NNS
cord-281188-0cql96hu	66	109	necessary	necessary	JJ
cord-281188-0cql96hu	66	110	for	for	IN
cord-281188-0cql96hu	66	111	killing	kill	VBG
cord-281188-0cql96hu	66	112	than	than	IN
cord-281188-0cql96hu	66	113	those	those	DT
cord-281188-0cql96hu	66	114	with	with	IN
cord-281188-0cql96hu	66	115	greater	great	JJR
cord-281188-0cql96hu	66	116	affinity	affinity	NN
cord-281188-0cql96hu	66	117	23	23	CD
cord-281188-0cql96hu	66	118	;	;	:
cord-281188-0cql96hu	66	119	(	(	-LRB-
cord-281188-0cql96hu	66	120	5	5	LS
cord-281188-0cql96hu	66	121	)	)	-RRB-
cord-281188-0cql96hu	66	122	the	the	DT
cord-281188-0cql96hu	66	123	targeted	target	VBN
cord-281188-0cql96hu	66	124	function	function	NN
cord-281188-0cql96hu	66	125	might	may	MD
cord-281188-0cql96hu	66	126	increase	increase	VB
cord-281188-0cql96hu	66	127	in	in	IN
cord-281188-0cql96hu	66	128	the	the	DT
cord-281188-0cql96hu	66	129	presence	presence	NN
cord-281188-0cql96hu	66	130	of	of	IN
cord-281188-0cql96hu	66	131	the	the	DT
cord-281188-0cql96hu	66	132	drug	drug	NN
cord-281188-0cql96hu	66	133	,	,	,
cord-281188-0cql96hu	66	134	thereby	thereby	RB
cord-281188-0cql96hu	66	135	compensating	compensate	VBG
cord-281188-0cql96hu	66	136	for	for	IN
cord-281188-0cql96hu	66	137	the	the	DT
cord-281188-0cql96hu	66	138	inhibition	inhibition	NN
cord-281188-0cql96hu	66	139	by	by	IN
cord-281188-0cql96hu	66	140	the	the	DT
cord-281188-0cql96hu	66	141	drug	drug	NN
cord-281188-0cql96hu	66	142	24	24	CD
cord-281188-0cql96hu	66	143	;	;	:
cord-281188-0cql96hu	66	144	(	(	-LRB-
cord-281188-0cql96hu	66	145	6	6	LS
cord-281188-0cql96hu	66	146	)	)	-RRB-
cord-281188-0cql96hu	66	147	the	the	DT
cord-281188-0cql96hu	66	148	target	target	NN
cord-281188-0cql96hu	66	149	function	function	NN
cord-281188-0cql96hu	66	150	corresponds	correspond	VBZ
cord-281188-0cql96hu	66	151	to	to	IN
cord-281188-0cql96hu	66	152	the	the	DT
cord-281188-0cql96hu	66	153	build	build	NN
cord-281188-0cql96hu	66	154	-	-	HYPH
cord-281188-0cql96hu	66	155	up	up	NN
cord-281188-0cql96hu	66	156	of	of	IN
cord-281188-0cql96hu	66	157	a	a	DT
cord-281188-0cql96hu	66	158	cellular	cellular	JJ
cord-281188-0cql96hu	66	159	structure	structure	NN
cord-281188-0cql96hu	66	160	with	with	IN
cord-281188-0cql96hu	66	161	slow	slow	JJ
cord-281188-0cql96hu	66	162	turnover	turnover	NN
cord-281188-0cql96hu	66	163	,	,	,
cord-281188-0cql96hu	66	164	which	which	WDT
cord-281188-0cql96hu	66	165	increases	increase	VBZ
cord-281188-0cql96hu	66	166	the	the	DT
cord-281188-0cql96hu	66	167	amount	amount	NN
cord-281188-0cql96hu	66	168	of	of	IN
cord-281188-0cql96hu	66	169	time	time	NN
cord-281188-0cql96hu	66	170	for	for	IN
cord-281188-0cql96hu	66	171	the	the	DT
cord-281188-0cql96hu	66	172	antibiotic	antibiotic	NN
cord-281188-0cql96hu	66	173	to	to	TO
cord-281188-0cql96hu	66	174	kill	kill	VB
cord-281188-0cql96hu	66	175	25,26	25,26	CD
cord-281188-0cql96hu	66	176	;	;	:
cord-281188-0cql96hu	66	177	(	(	-LRB-
cord-281188-0cql96hu	66	178	7	7	LS
cord-281188-0cql96hu	66	179	)	)	-RRB-
cord-281188-0cql96hu	66	180	the	the	DT
cord-281188-0cql96hu	66	181	cells	cell	NNS
cord-281188-0cql96hu	66	182	repair	repair	VBP
cord-281188-0cql96hu	66	183	the	the	DT
cord-281188-0cql96hu	66	184	damage	damage	NN
cord-281188-0cql96hu	66	185	produced	produce	VBN
cord-281188-0cql96hu	66	186	by	by	IN
cord-281188-0cql96hu	66	187	the	the	DT
cord-281188-0cql96hu	66	188	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	66	189	at	at	IN
cord-281188-0cql96hu	66	190	rates	rate	NNS
cord-281188-0cql96hu	66	191	that	that	WDT
cord-281188-0cql96hu	66	192	differ	differ	VBP
cord-281188-0cql96hu	66	193	between	between	IN
cord-281188-0cql96hu	66	194	drugs	drug	NNS
cord-281188-0cql96hu	66	195	27	27	CD
cord-281188-0cql96hu	66	196	;	;	:
cord-281188-0cql96hu	66	197	(	(	-LRB-
cord-281188-0cql96hu	66	198	8)	8)	NNP
cord-281188-0cql96hu	66	199	the	the	DT
cord-281188-0cql96hu	66	200	damaged	damage	VBN
cord-281188-0cql96hu	66	201	bacteria	bacteria	NNS
cord-281188-0cql96hu	66	202	have	have	VBP
cord-281188-0cql96hu	66	203	inducible	inducible	JJ
cord-281188-0cql96hu	66	204	antibiotic	antibiotic	RB
cord-281188-0cql96hu	66	205	-	-	HYPH
cord-281188-0cql96hu	66	206	deactivating	deactivate	VBG
cord-281188-0cql96hu	66	207	mechanisms	mechanism	NNS
cord-281188-0cql96hu	66	208	28	28	CD
cord-281188-0cql96hu	66	209	;	;	:
cord-281188-0cql96hu	66	210	(	(	-LRB-
cord-281188-0cql96hu	66	211	9	9	LS
cord-281188-0cql96hu	66	212	)	)	-RRB-
cord-281188-0cql96hu	66	213	the	the	DT
cord-281188-0cql96hu	66	214	bacteria	bacteria	NNS
cord-281188-0cql96hu	66	215	use	use	VBP
cord-281188-0cql96hu	66	216	alternative	alternative	JJ
cord-281188-0cql96hu	66	217	metabolic	metabolic	JJ
cord-281188-0cql96hu	66	218	pathways	pathway	NNS
cord-281188-0cql96hu	66	219	that	that	WDT
cord-281188-0cql96hu	66	220	,	,	,
cord-281188-0cql96hu	66	221	to	to	IN
cord-281188-0cql96hu	66	222	some	some	DT
cord-281188-0cql96hu	66	223	extent	extent	NN
cord-281188-0cql96hu	66	224	,	,	,
cord-281188-0cql96hu	66	225	bypass	bypass	VB
cord-281188-0cql96hu	66	226	those	those	DT
cord-281188-0cql96hu	66	227	inhibited	inhibit	VBN
cord-281188-0cql96hu	66	228	by	by	IN
cord-281188-0cql96hu	66	229	the	the	DT
cord-281188-0cql96hu	66	230	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	66	231	29	29	CD
cord-281188-0cql96hu	66	232	,	,	,
cord-281188-0cql96hu	66	233	30	30	CD
cord-281188-0cql96hu	66	234	;	;	:
cord-281188-0cql96hu	66	235	(	(	-LRB-
cord-281188-0cql96hu	66	236	10	10	CD
cord-281188-0cql96hu	66	237	)	)	-RRB-
cord-281188-0cql96hu	66	238	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	66	239	differ	differ	VBP
cord-281188-0cql96hu	66	240	in	in	IN
cord-281188-0cql96hu	66	241	the	the	DT
cord-281188-0cql96hu	66	242	extent	extent	NN
cord-281188-0cql96hu	66	243	to	to	TO
cord-281188-0cql96hu	66	244	which	which	WDT
cord-281188-0cql96hu	66	245	they	-PRON-	PRP
cord-281188-0cql96hu	66	246	induce	induce	VBP
cord-281188-0cql96hu	66	247	reactive	reactive	JJ
cord-281188-0cql96hu	66	248	oxygen	oxygen	NN
cord-281188-0cql96hu	66	249	species	specie	NNS
cord-281188-0cql96hu	66	250	(	(	-LRB-
cord-281188-0cql96hu	66	251	ROS	ROS	NNP
cord-281188-0cql96hu	66	252	;	;	:
cord-281188-0cql96hu	66	253	deleterious	deleterious	JJ
cord-281188-0cql96hu	66	254	)	)	-RRB-
cord-281188-0cql96hu	66	255	or	or	CC
cord-281188-0cql96hu	66	256	SOS	SOS	NNP
cord-281188-0cql96hu	66	257	(	(	-LRB-
cord-281188-0cql96hu	66	258	potentially	potentially	RB
cord-281188-0cql96hu	66	259	protective	protective	JJ
cord-281188-0cql96hu	66	260	)	)	-RRB-
cord-281188-0cql96hu	66	261	responses	response	NNS
cord-281188-0cql96hu	66	262	and	and	CC
cord-281188-0cql96hu	66	263	thereby	thereby	RB
cord-281188-0cql96hu	66	264	the	the	DT
cord-281188-0cql96hu	66	265	rate	rate	NN
cord-281188-0cql96hu	66	266	at	at	IN
cord-281188-0cql96hu	66	267	which	which	WDT
cord-281188-0cql96hu	66	268	they	-PRON-	PRP
cord-281188-0cql96hu	66	269	kill	kill	VBP
cord-281188-0cql96hu	66	270	the	the	DT
cord-281188-0cql96hu	66	271	exposed	expose	VBN
cord-281188-0cql96hu	66	272	bacteria	bacteria	NNS
cord-281188-0cql96hu	66	273	[	[	-LRB-
cord-281188-0cql96hu	66	274	31	31	CD
cord-281188-0cql96hu	66	275	]	]	-RRB-
cord-281188-0cql96hu	66	276	[	[	-LRB-
cord-281188-0cql96hu	66	277	32	32	CD
cord-281188-0cql96hu	66	278	]	]	-RRB-
cord-281188-0cql96hu	66	279	[	[	-LRB-
cord-281188-0cql96hu	66	280	33	33	CD
cord-281188-0cql96hu	66	281	]	]	-RRB-
cord-281188-0cql96hu	66	282	[	[	-LRB-
cord-281188-0cql96hu	66	283	34	34	CD
cord-281188-0cql96hu	66	284	]	]	-RRB-
cord-281188-0cql96hu	66	285	;	;	:
cord-281188-0cql96hu	66	286	(	(	-LRB-
cord-281188-0cql96hu	66	287	11	11	CD
cord-281188-0cql96hu	66	288	)	)	-RRB-
cord-281188-0cql96hu	66	289	members	member	NNS
cord-281188-0cql96hu	66	290	of	of	IN
cord-281188-0cql96hu	66	291	the	the	DT
cord-281188-0cql96hu	66	292	antibiotic	antibiotic	NN
cord-281188-0cql96hu	66	293	-	-	HYPH
cord-281188-0cql96hu	66	294	exposed	expose	VBN
cord-281188-0cql96hu	66	295	populations	population	NNS
cord-281188-0cql96hu	66	296	are	be	VBP
cord-281188-0cql96hu	66	297	either	either	CC
cord-281188-0cql96hu	66	298	www.nature.com/nrmicro	www.nature.com/nrmicro	NNP
cord-281188-0cql96hu	66	299	not	not	RB
cord-281188-0cql96hu	66	300	replicating	replicate	VBG
cord-281188-0cql96hu	66	301	or	or	CC
cord-281188-0cql96hu	66	302	are	be	VBP
cord-281188-0cql96hu	66	303	replicating	replicate	VBG
cord-281188-0cql96hu	66	304	slowly	slowly	RB
cord-281188-0cql96hu	66	305	,	,	,
cord-281188-0cql96hu	66	306	and	and	CC
cord-281188-0cql96hu	66	307	as	as	IN
cord-281188-0cql96hu	66	308	such	such	JJ
cord-281188-0cql96hu	66	309	are	be	VBP
cord-281188-0cql96hu	66	310	killed	kill	VBN
cord-281188-0cql96hu	66	311	at	at	IN
cord-281188-0cql96hu	66	312	lower	low	JJR
cord-281188-0cql96hu	66	313	rates	rate	NNS
cord-281188-0cql96hu	66	314	than	than	IN
cord-281188-0cql96hu	66	315	the	the	DT
cord-281188-0cql96hu	66	316	more	more	RBR
cord-281188-0cql96hu	66	317	active	active	JJ
cord-281188-0cql96hu	66	318	members	member	NNS
cord-281188-0cql96hu	66	319	of	of	IN
cord-281188-0cql96hu	66	320	the	the	DT
cord-281188-0cql96hu	66	321	population	population	NN
cord-281188-0cql96hu	66	322	or	or	CC
cord-281188-0cql96hu	66	323	their	-PRON-	PRP$
cord-281188-0cql96hu	66	324	death	death	NN
cord-281188-0cql96hu	66	325	is	be	VBZ
cord-281188-0cql96hu	66	326	delayed	delay	VBN
cord-281188-0cql96hu	66	327	;	;	:
cord-281188-0cql96hu	66	328	(	(	-LRB-
cord-281188-0cql96hu	66	329	12	12	CD
cord-281188-0cql96hu	66	330	)	)	-RRB-
cord-281188-0cql96hu	66	331	the	the	DT
cord-281188-0cql96hu	66	332	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	66	333	produce	produce	VBP
cord-281188-0cql96hu	66	334	a	a	DT
cord-281188-0cql96hu	66	335	kind	kind	NN
cord-281188-0cql96hu	66	336	of	of	IN
cord-281188-0cql96hu	66	337	'	'	``
cord-281188-0cql96hu	66	338	stationary	stationary	JJ
cord-281188-0cql96hu	66	339	phase	phase	NN
cord-281188-0cql96hu	66	340	'	'	''
cord-281188-0cql96hu	66	341	by	by	IN
cord-281188-0cql96hu	66	342	activating	activate	VBG
cord-281188-0cql96hu	66	343	the	the	DT
cord-281188-0cql96hu	66	344	general	general	JJ
cord-281188-0cql96hu	66	345	RpoS	RpoS	NNP
cord-281188-0cql96hu	66	346	-	-	HYPH
cord-281188-0cql96hu	66	347	mediated	mediate	VBN
cord-281188-0cql96hu	66	348	stringent	stringent	JJ
cord-281188-0cql96hu	66	349	response	response	NN
cord-281188-0cql96hu	66	350	35	35	CD
cord-281188-0cql96hu	66	351	.	.	.
cord-281188-0cql96hu	67	1	Notably	notably	RB
cord-281188-0cql96hu	67	2	,	,	,
cord-281188-0cql96hu	67	3	under	under	IN
cord-281188-0cql96hu	67	4	very	very	RB
cord-281188-0cql96hu	67	5	effective	effective	JJ
cord-281188-0cql96hu	67	6	'	'	''
cord-281188-0cql96hu	67	7	death	death	NN
cord-281188-0cql96hu	67	8	-	-	HYPH
cord-281188-0cql96hu	67	9	delaying	delay	VBG
cord-281188-0cql96hu	67	10	conditions	condition	NNS
cord-281188-0cql96hu	67	11	'	'	''
cord-281188-0cql96hu	67	12	,	,	,
cord-281188-0cql96hu	67	13	before	before	IN
cord-281188-0cql96hu	67	14	the	the	DT
cord-281188-0cql96hu	67	15	point	point	NN
cord-281188-0cql96hu	67	16	of	of	IN
cord-281188-0cql96hu	67	17	no	no	DT
cord-281188-0cql96hu	67	18	return	return	NN
cord-281188-0cql96hu	67	19	is	be	VBZ
cord-281188-0cql96hu	67	20	reached	reach	VBN
cord-281188-0cql96hu	67	21	,	,	,
cord-281188-0cql96hu	67	22	it	-PRON-	PRP
cord-281188-0cql96hu	67	23	would	would	MD
cord-281188-0cql96hu	67	24	be	be	VB
cord-281188-0cql96hu	67	25	difficult	difficult	JJ
cord-281188-0cql96hu	67	26	to	to	TO
cord-281188-0cql96hu	67	27	determine	determine	VB
cord-281188-0cql96hu	67	28	whether	whether	IN
cord-281188-0cql96hu	67	29	a	a	DT
cord-281188-0cql96hu	67	30	cell	cell	NN
cord-281188-0cql96hu	67	31	is	be	VBZ
cord-281188-0cql96hu	67	32	in	in	IN
cord-281188-0cql96hu	67	33	the	the	DT
cord-281188-0cql96hu	67	34	process	process	NN
cord-281188-0cql96hu	67	35	of	of	IN
cord-281188-0cql96hu	67	36	dying	die	VBG
cord-281188-0cql96hu	67	37	.	.	.
cord-281188-0cql96hu	68	1	However	however	RB
cord-281188-0cql96hu	68	2	,	,	,
cord-281188-0cql96hu	68	3	when	when	WRB
cord-281188-0cql96hu	68	4	this	this	DT
cord-281188-0cql96hu	68	5	point	point	NN
cord-281188-0cql96hu	68	6	of	of	IN
cord-281188-0cql96hu	68	7	no	no	DT
cord-281188-0cql96hu	68	8	return	return	NN
cord-281188-0cql96hu	68	9	is	be	VBZ
cord-281188-0cql96hu	68	10	surpassed	surpass	VBN
cord-281188-0cql96hu	68	11	,	,	,
cord-281188-0cql96hu	68	12	the	the	DT
cord-281188-0cql96hu	68	13	last	last	JJ
cord-281188-0cql96hu	68	14	resources	resource	NNS
cord-281188-0cql96hu	68	15	are	be	VBP
cord-281188-0cql96hu	68	16	invested	invest	VBN
cord-281188-0cql96hu	68	17	in	in	IN
cord-281188-0cql96hu	68	18	programmed	programmed	JJ
cord-281188-0cql96hu	68	19	cell	cell	NN
cord-281188-0cql96hu	68	20	death	death	NN
cord-281188-0cql96hu	68	21	,	,	,
cord-281188-0cql96hu	68	22	and	and	CC
cord-281188-0cql96hu	68	23	the	the	DT
cord-281188-0cql96hu	68	24	bacterium	bacterium	NN
cord-281188-0cql96hu	68	25	induces	induce	VBZ
cord-281188-0cql96hu	68	26	its	-PRON-	PRP$
cord-281188-0cql96hu	68	27	own	own	JJ
cord-281188-0cql96hu	68	28	lysis	lysis	NN
cord-281188-0cql96hu	68	29	and	and	CC
cord-281188-0cql96hu	68	30	DNA	dna	NN
cord-281188-0cql96hu	68	31	degradation	degradation	NN
cord-281188-0cql96hu	68	32	(	(	-LRB-
cord-281188-0cql96hu	68	33	apoptosis	apoptosis	NN
cord-281188-0cql96hu	68	34	)	)	-RRB-
cord-281188-0cql96hu	68	35	36	36	CD
cord-281188-0cql96hu	68	36	.	.	.
cord-281188-0cql96hu	69	1	Although	although	IN
cord-281188-0cql96hu	69	2	it	-PRON-	PRP
cord-281188-0cql96hu	69	3	is	be	VBZ
cord-281188-0cql96hu	69	4	convenient	convenient	JJ
cord-281188-0cql96hu	69	5	for	for	IN
cord-281188-0cql96hu	69	6	investigators	investigator	NNS
cord-281188-0cql96hu	69	7	to	to	TO
cord-281188-0cql96hu	69	8	separately	separately	RB
cord-281188-0cql96hu	69	9	consider	consider	VB
cord-281188-0cql96hu	69	10	the	the	DT
cord-281188-0cql96hu	69	11	pharmacodynamics	pharmacodynamic	NNS
cord-281188-0cql96hu	69	12	of	of	IN
cord-281188-0cql96hu	69	13	the	the	DT
cord-281188-0cql96hu	69	14	interaction	interaction	NN
cord-281188-0cql96hu	69	15	of	of	IN
cord-281188-0cql96hu	69	16	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	69	17	and	and	CC
cord-281188-0cql96hu	69	18	bacteria	bacteria	NNS
cord-281188-0cql96hu	69	19	and	and	CC
cord-281188-0cql96hu	69	20	the	the	DT
cord-281188-0cql96hu	69	21	changes	change	NNS
cord-281188-0cql96hu	69	22	in	in	IN
cord-281188-0cql96hu	69	23	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	69	24	concentration	concentration	NN
cord-281188-0cql96hu	69	25	with	with	IN
cord-281188-0cql96hu	69	26	different	different	JJ
cord-281188-0cql96hu	69	27	therapeutic	therapeutic	JJ
cord-281188-0cql96hu	69	28	schedules	schedule	NNS
cord-281188-0cql96hu	69	29	(	(	-LRB-
cord-281188-0cql96hu	69	30	that	that	RB
cord-281188-0cql96hu	69	31	is	is	RB
cord-281188-0cql96hu	69	32	,	,	,
cord-281188-0cql96hu	69	33	the	the	DT
cord-281188-0cql96hu	69	34	pharmacokinetics	pharmacokinetic	NNS
cord-281188-0cql96hu	69	35	of	of	IN
cord-281188-0cql96hu	69	36	the	the	DT
cord-281188-0cql96hu	69	37	drug	drug	NN
cord-281188-0cql96hu	69	38	)	)	-RRB-
cord-281188-0cql96hu	69	39	,	,	,
cord-281188-0cql96hu	69	40	bacteria	bacteria	NNS
cord-281188-0cql96hu	69	41	do	do	VBP
cord-281188-0cql96hu	69	42	not	not	RB
cord-281188-0cql96hu	69	43	have	have	VB
cord-281188-0cql96hu	69	44	that	that	DT
cord-281188-0cql96hu	69	45	luxury	luxury	NN
cord-281188-0cql96hu	69	46	-the	-the	ADD
cord-281188-0cql96hu	69	47	pharmacodynamics	pharmacodynamic	NNS
cord-281188-0cql96hu	69	48	of	of	IN
cord-281188-0cql96hu	69	49	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	69	50	action	action	NN
cord-281188-0cql96hu	69	51	is	be	VBZ
cord-281188-0cql96hu	69	52	highly	highly	RB
cord-281188-0cql96hu	69	53	dependent	dependent	JJ
cord-281188-0cql96hu	69	54	on	on	IN
cord-281188-0cql96hu	69	55	pharmacokinetics	pharmacokinetic	NNS
cord-281188-0cql96hu	69	56	.	.	.
cord-281188-0cql96hu	70	1	On	on	IN
cord-281188-0cql96hu	70	2	first	first	JJ
cord-281188-0cql96hu	70	3	consideration	consideration	NN
cord-281188-0cql96hu	70	4	,	,	,
cord-281188-0cql96hu	70	5	it	-PRON-	PRP
cord-281188-0cql96hu	70	6	would	would	MD
cord-281188-0cql96hu	70	7	seem	seem	VB
cord-281188-0cql96hu	70	8	the	the	DT
cord-281188-0cql96hu	70	9	higher	high	JJR
cord-281188-0cql96hu	70	10	the	the	DT
cord-281188-0cql96hu	70	11	concentration	concentration	NN
cord-281188-0cql96hu	70	12	of	of	IN
cord-281188-0cql96hu	70	13	the	the	DT
cord-281188-0cql96hu	70	14	drug	drug	NN
cord-281188-0cql96hu	70	15	to	to	TO
cord-281188-0cql96hu	70	16	which	which	WDT
cord-281188-0cql96hu	70	17	the	the	DT
cord-281188-0cql96hu	70	18	bacteria	bacteria	NNS
cord-281188-0cql96hu	70	19	are	be	VBP
cord-281188-0cql96hu	70	20	exposed	expose	VBN
cord-281188-0cql96hu	70	21	,	,	,
cord-281188-0cql96hu	70	22	the	the	DT
cord-281188-0cql96hu	70	23	higher	high	JJR
cord-281188-0cql96hu	70	24	the	the	DT
cord-281188-0cql96hu	70	25	rate	rate	NN
cord-281188-0cql96hu	70	26	at	at	IN
cord-281188-0cql96hu	70	27	which	which	WDT
cord-281188-0cql96hu	70	28	they	-PRON-	PRP
cord-281188-0cql96hu	70	29	are	be	VBP
cord-281188-0cql96hu	70	30	killed	kill	VBN
cord-281188-0cql96hu	70	31	.	.	.
cord-281188-0cql96hu	71	1	This	this	DT
cord-281188-0cql96hu	71	2	is	be	VBZ
cord-281188-0cql96hu	71	3	the	the	DT
cord-281188-0cql96hu	71	4	case	case	NN
cord-281188-0cql96hu	71	5	for	for	IN
cord-281188-0cql96hu	71	6	many	many	JJ
cord-281188-0cql96hu	71	7	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	71	8	,	,	,
cord-281188-0cql96hu	71	9	but	but	CC
cord-281188-0cql96hu	71	10	not	not	RB
cord-281188-0cql96hu	71	11	for	for	IN
cord-281188-0cql96hu	71	12	all	all	DT
cord-281188-0cql96hu	71	13	.	.	.
cord-281188-0cql96hu	72	1	Commonly	commonly	RB
cord-281188-0cql96hu	72	2	,	,	,
cord-281188-0cql96hu	72	3	but	but	CC
cord-281188-0cql96hu	72	4	not	not	RB
cord-281188-0cql96hu	72	5	universally	universally	RB
cord-281188-0cql96hu	72	6	,	,	,
cord-281188-0cql96hu	72	7	the	the	DT
cord-281188-0cql96hu	72	8	rate	rate	NN
cord-281188-0cql96hu	72	9	at	at	IN
cord-281188-0cql96hu	72	10	which	which	WDT
cord-281188-0cql96hu	72	11	bacteria	bacteria	NNS
cord-281188-0cql96hu	72	12	are	be	VBP
cord-281188-0cql96hu	72	13	killed	kill	VBN
cord-281188-0cql96hu	72	14	by	by	IN
cord-281188-0cql96hu	72	15	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	72	16	is	be	VBZ
cord-281188-0cql96hu	72	17	proportional	proportional	JJ
cord-281188-0cql96hu	72	18	to	to	IN
cord-281188-0cql96hu	72	19	the	the	DT
cord-281188-0cql96hu	72	20	maximum	maximum	JJ
cord-281188-0cql96hu	72	21	rates	rate	NNS
cord-281188-0cql96hu	72	22	of	of	IN
cord-281188-0cql96hu	72	23	growth	growth	NN
cord-281188-0cql96hu	72	24	of	of	IN
cord-281188-0cql96hu	72	25	their	-PRON-	PRP$
cord-281188-0cql96hu	72	26	populations	population	NNS
cord-281188-0cql96hu	72	27	37	37	CD
cord-281188-0cql96hu	72	28	.	.	.
cord-281188-0cql96hu	73	1	One	one	CD
cord-281188-0cql96hu	73	2	interpretation	interpretation	NN
cord-281188-0cql96hu	73	3	of	of	IN
cord-281188-0cql96hu	73	4	this	this	DT
cord-281188-0cql96hu	73	5	association	association	NN
cord-281188-0cql96hu	73	6	is	be	VBZ
cord-281188-0cql96hu	73	7	that	that	DT
cord-281188-0cql96hu	73	8	death	death	NN
cord-281188-0cql96hu	73	9	occurs	occur	VBZ
cord-281188-0cql96hu	73	10	when	when	WRB
cord-281188-0cql96hu	73	11	the	the	DT
cord-281188-0cql96hu	73	12	demand	demand	NN
cord-281188-0cql96hu	73	13	for	for	IN
cord-281188-0cql96hu	73	14	resources	resource	NNS
cord-281188-0cql96hu	73	15	is	be	VBZ
cord-281188-0cql96hu	73	16	great	great	JJ
cord-281188-0cql96hu	73	17	,	,	,
cord-281188-0cql96hu	73	18	and	and	CC
cord-281188-0cql96hu	73	19	the	the	DT
cord-281188-0cql96hu	73	20	amount	amount	NN
cord-281188-0cql96hu	73	21	of	of	IN
cord-281188-0cql96hu	73	22	resources	resource	NNS
cord-281188-0cql96hu	73	23	is	be	VBZ
cord-281188-0cql96hu	73	24	severely	severely	RB
cord-281188-0cql96hu	73	25	limited	limit	VBN
cord-281188-0cql96hu	73	26	by	by	IN
cord-281188-0cql96hu	73	27	drug	drug	NN
cord-281188-0cql96hu	73	28	action	action	NN
cord-281188-0cql96hu	73	29	.	.	.
cord-281188-0cql96hu	74	1	If	if	IN
cord-281188-0cql96hu	74	2	only	only	RB
cord-281188-0cql96hu	74	3	a	a	DT
cord-281188-0cql96hu	74	4	fraction	fraction	NN
cord-281188-0cql96hu	74	5	of	of	IN
cord-281188-0cql96hu	74	6	the	the	DT
cord-281188-0cql96hu	74	7	population	population	NN
cord-281188-0cql96hu	74	8	of	of	IN
cord-281188-0cql96hu	74	9	bacteria	bacteria	NNS
cord-281188-0cql96hu	74	10	is	be	VBZ
cord-281188-0cql96hu	74	11	in	in	IN
cord-281188-0cql96hu	74	12	a	a	DT
cord-281188-0cql96hu	74	13	'	'	``
cord-281188-0cql96hu	74	14	susceptible	susceptible	JJ
cord-281188-0cql96hu	74	15	mode	mode	NN
cord-281188-0cql96hu	74	16	'	'	''
cord-281188-0cql96hu	74	17	(	(	-LRB-
cord-281188-0cql96hu	74	18	replicating	replicate	VBG
cord-281188-0cql96hu	74	19	)	)	-RRB-
cord-281188-0cql96hu	74	20	at	at	IN
cord-281188-0cql96hu	74	21	any	any	DT
cord-281188-0cql96hu	74	22	time	time	NN
cord-281188-0cql96hu	74	23	,	,	,
cord-281188-0cql96hu	74	24	the	the	DT
cord-281188-0cql96hu	74	25	full	full	JJ
cord-281188-0cql96hu	74	26	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	74	27	activity	activity	NN
cord-281188-0cql96hu	74	28	will	will	MD
cord-281188-0cql96hu	74	29	be	be	VB
cord-281188-0cql96hu	74	30	achieved	achieve	VBN
cord-281188-0cql96hu	74	31	only	only	RB
cord-281188-0cql96hu	74	32	after	after	IN
cord-281188-0cql96hu	74	33	prolonged	prolonged	JJ
cord-281188-0cql96hu	74	34	periods	period	NNS
cord-281188-0cql96hu	74	35	of	of	IN
cord-281188-0cql96hu	74	36	exposure	exposure	NN
cord-281188-0cql96hu	74	37	(	(	-LRB-
cord-281188-0cql96hu	74	38	time	time	NN
cord-281188-0cql96hu	74	39	-	-	HYPH
cord-281188-0cql96hu	74	40	dependent	dependent	JJ
cord-281188-0cql96hu	74	41	killing	killing	NN
cord-281188-0cql96hu	74	42	,	,	,
cord-281188-0cql96hu	74	43	as	as	IN
cord-281188-0cql96hu	74	44	is	be	VBZ
cord-281188-0cql96hu	74	45	the	the	DT
cord-281188-0cql96hu	74	46	case	case	NN
cord-281188-0cql96hu	74	47	of	of	IN
cord-281188-0cql96hu	74	48	β	β	NN
cord-281188-0cql96hu	74	49	-	-	HYPH
cord-281188-0cql96hu	74	50	lactams	lactams	NNPS
cord-281188-0cql96hu	74	51	)	)	-RRB-
cord-281188-0cql96hu	74	52	38	38	CD
cord-281188-0cql96hu	74	53	.	.	.
cord-281188-0cql96hu	75	1	On	on	IN
cord-281188-0cql96hu	75	2	the	the	DT
cord-281188-0cql96hu	75	3	pharmacodynamics	pharmacodynamic	NNS
cord-281188-0cql96hu	75	4	side	side	NN
cord-281188-0cql96hu	75	5	,	,	,
cord-281188-0cql96hu	75	6	it	-PRON-	PRP
cord-281188-0cql96hu	75	7	may	may	MD
cord-281188-0cql96hu	75	8	well	well	RB
cord-281188-0cql96hu	75	9	be	be	VB
cord-281188-0cql96hu	75	10	that	that	IN
cord-281188-0cql96hu	75	11	the	the	DT
cord-281188-0cql96hu	75	12	rate	rate	NN
cord-281188-0cql96hu	75	13	at	at	IN
cord-281188-0cql96hu	75	14	which	which	WDT
cord-281188-0cql96hu	75	15	bacteria	bacteria	NNS
cord-281188-0cql96hu	75	16	are	be	VBP
cord-281188-0cql96hu	75	17	killed	kill	VBN
cord-281188-0cql96hu	75	18	depends	depend	VBZ
cord-281188-0cql96hu	75	19	on	on	IN
cord-281188-0cql96hu	75	20	the	the	DT
cord-281188-0cql96hu	75	21	multiplicity	multiplicity	NN
cord-281188-0cql96hu	75	22	of	of	IN
cord-281188-0cql96hu	75	23	targets	target	NNS
cord-281188-0cql96hu	75	24	simultaneously	simultaneously	RB
cord-281188-0cql96hu	75	25	affected	affect	VBN
cord-281188-0cql96hu	75	26	by	by	IN
cord-281188-0cql96hu	75	27	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	75	28	action	action	NN
cord-281188-0cql96hu	75	29	,	,	,
cord-281188-0cql96hu	75	30	which	which	WDT
cord-281188-0cql96hu	75	31	provokes	provoke	VBZ
cord-281188-0cql96hu	75	32	a	a	DT
cord-281188-0cql96hu	75	33	chaotic	chaotic	JJ
cord-281188-0cql96hu	75	34	and	and	CC
cord-281188-0cql96hu	75	35	difficult	difficult	JJ
cord-281188-0cql96hu	75	36	-	-	HYPH
cord-281188-0cql96hu	75	37	to	to	TO
cord-281188-0cql96hu	75	38	-	-	HYPH
cord-281188-0cql96hu	75	39	compensate	compensate	VB
cord-281188-0cql96hu	75	40	chemical	chemical	NN
cord-281188-0cql96hu	75	41	destructuring	destructuring	NN
cord-281188-0cql96hu	75	42	of	of	IN
cord-281188-0cql96hu	75	43	the	the	DT
cord-281188-0cql96hu	75	44	cell	cell	NN
cord-281188-0cql96hu	75	45	.	.	.
cord-281188-0cql96hu	76	1	This	this	DT
cord-281188-0cql96hu	76	2	sort	sort	NN
cord-281188-0cql96hu	76	3	of	of	IN
cord-281188-0cql96hu	76	4	mechanism	mechanism	NN
cord-281188-0cql96hu	76	5	has	have	VBZ
cord-281188-0cql96hu	76	6	been	be	VBN
cord-281188-0cql96hu	76	7	invoked	invoke	VBN
cord-281188-0cql96hu	76	8	to	to	TO
cord-281188-0cql96hu	76	9	explain	explain	VB
cord-281188-0cql96hu	76	10	the	the	DT
cord-281188-0cql96hu	76	11	rapid	rapid	JJ
cord-281188-0cql96hu	76	12	killing	killing	NN
cord-281188-0cql96hu	76	13	(	(	-LRB-
cord-281188-0cql96hu	76	14	minutes	minute	NNS
cord-281188-0cql96hu	76	15	)	)	-RRB-
cord-281188-0cql96hu	76	16	by	by	IN
cord-281188-0cql96hu	76	17	most	most	JJS
cord-281188-0cql96hu	76	18	biocides	biocide	NNS
cord-281188-0cql96hu	76	19	,	,	,
cord-281188-0cql96hu	76	20	such	such	JJ
cord-281188-0cql96hu	76	21	as	as	IN
cord-281188-0cql96hu	76	22	disinfectants	disinfectant	NNS
cord-281188-0cql96hu	76	23	or	or	CC
cord-281188-0cql96hu	76	24	antiseptics	antiseptic	NNS
cord-281188-0cql96hu	76	25	39	39	CD
cord-281188-0cql96hu	76	26	,	,	,
cord-281188-0cql96hu	76	27	40	40	CD
cord-281188-0cql96hu	76	28	.	.	.
cord-281188-0cql96hu	77	1	This	this	DT
cord-281188-0cql96hu	77	2	rapid	rapid	JJ
cord-281188-0cql96hu	77	3	death	death	NN
cord-281188-0cql96hu	77	4	by	by	IN
cord-281188-0cql96hu	77	5	'	'	``
cord-281188-0cql96hu	77	6	multiple	multiple	JJ
cord-281188-0cql96hu	77	7	targets	target	NNS
cord-281188-0cql96hu	77	8	'	'	''
cord-281188-0cql96hu	77	9	is	be	VBZ
cord-281188-0cql96hu	77	10	also	also	RB
cord-281188-0cql96hu	77	11	consistent	consistent	JJ
cord-281188-0cql96hu	77	12	with	with	IN
cord-281188-0cql96hu	77	13	the	the	DT
cord-281188-0cql96hu	77	14	frequent	frequent	JJ
cord-281188-0cql96hu	77	15	increase	increase	NN
cord-281188-0cql96hu	77	16	in	in	IN
cord-281188-0cql96hu	77	17	the	the	DT
cord-281188-0cql96hu	77	18	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	77	19	effect	effect	NN
cord-281188-0cql96hu	77	20	measured	measure	VBN
cord-281188-0cql96hu	77	21	in	in	IN
cord-281188-0cql96hu	77	22	time	time	NN
cord-281188-0cql96hu	77	23	-	-	HYPH
cord-281188-0cql96hu	77	24	kill	kill	NN
cord-281188-0cql96hu	77	25	curves	curve	NNS
cord-281188-0cql96hu	77	26	of	of	IN
cord-281188-0cql96hu	77	27	synergistic	synergistic	JJ
cord-281188-0cql96hu	77	28	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	77	29	combinations	combination	NNS
cord-281188-0cql96hu	77	30	41	41	CD
cord-281188-0cql96hu	77	31	or	or	CC
cord-281188-0cql96hu	77	32	in	in	IN
cord-281188-0cql96hu	77	33	phage	phage	NN
cord-281188-0cql96hu	77	34	-	-	HYPH
cord-281188-0cql96hu	77	35	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	77	36	combinations	combination	NNS
cord-281188-0cql96hu	77	37	42	42	CD
cord-281188-0cql96hu	77	38	,	,	,
cord-281188-0cql96hu	77	39	43	43	CD
cord-281188-0cql96hu	77	40	.	.	.
cord-281188-0cql96hu	78	1	Considering	consider	VBG
cord-281188-0cql96hu	78	2	the	the	DT
cord-281188-0cql96hu	78	3	plethora	plethora	NN
cord-281188-0cql96hu	78	4	of	of	IN
cord-281188-0cql96hu	78	5	factors	factor	NNS
cord-281188-0cql96hu	78	6	contributing	contribute	VBG
cord-281188-0cql96hu	78	7	to	to	IN
cord-281188-0cql96hu	78	8	the	the	DT
cord-281188-0cql96hu	78	9	rates	rate	NNS
cord-281188-0cql96hu	78	10	at	at	IN
cord-281188-0cql96hu	78	11	which	which	WDT
cord-281188-0cql96hu	78	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	78	13	kill	kill	VBP
cord-281188-0cql96hu	78	14	bacteria	bacteria	NNS
cord-281188-0cql96hu	78	15	,	,	,
cord-281188-0cql96hu	78	16	we	-PRON-	PRP
cord-281188-0cql96hu	78	17	can	can	MD
cord-281188-0cql96hu	78	18	appreciate	appreciate	VB
cord-281188-0cql96hu	78	19	the	the	DT
cord-281188-0cql96hu	78	20	difficulty	difficulty	NN
cord-281188-0cql96hu	78	21	of	of	IN
cord-281188-0cql96hu	78	22	maintaining	maintain	VBG
cord-281188-0cql96hu	78	23	the	the	DT
cord-281188-0cql96hu	78	24	tradition	tradition	NN
cord-281188-0cql96hu	78	25	of	of	IN
cord-281188-0cql96hu	78	26	classifying	classify	VBG
cord-281188-0cql96hu	78	27	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	78	28	as	as	IN
cord-281188-0cql96hu	78	29	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	78	30	and	and	CC
cord-281188-0cql96hu	78	31	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	78	32	.	.	.
cord-281188-0cql96hu	79	1	As	as	IN
cord-281188-0cql96hu	79	2	noted	note	VBN
cord-281188-0cql96hu	79	3	in	in	IN
cord-281188-0cql96hu	79	4	fig	fig	NN
cord-281188-0cql96hu	79	5	.	.	.
cord-281188-0cql96hu	80	1	1	1	CD
cord-281188-0cql96hu	80	2	,	,	,
cord-281188-0cql96hu	80	3	at	at	IN
cord-281188-0cql96hu	80	4	the	the	DT
cord-281188-0cql96hu	80	5	concentration	concentration	NN
cord-281188-0cql96hu	80	6	used	use	VBN
cord-281188-0cql96hu	80	7	,	,	,
cord-281188-0cql96hu	80	8	as	as	IN
cord-281188-0cql96hu	80	9	measured	measure	VBN
cord-281188-0cql96hu	80	10	by	by	IN
cord-281188-0cql96hu	80	11	decline	decline	NN
cord-281188-0cql96hu	80	12	in	in	IN
cord-281188-0cql96hu	80	13	colony	colony	NN
cord-281188-0cql96hu	80	14	-	-	HYPH
cord-281188-0cql96hu	80	15	forming	form	VBG
cord-281188-0cql96hu	80	16	unit	unit	NN
cord-281188-0cql96hu	80	17	estimates	estimate	NNS
cord-281188-0cql96hu	80	18	of	of	IN
cord-281188-0cql96hu	80	19	densities	density	NNS
cord-281188-0cql96hu	80	20	,	,	,
cord-281188-0cql96hu	80	21	all	all	DT
cord-281188-0cql96hu	80	22	nine	nine	CD
cord-281188-0cql96hu	80	23	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	80	24	examined	examine	VBD
cord-281188-0cql96hu	80	25	killed	kill	VBN
cord-281188-0cql96hu	80	26	S.	S.	NNP
cord-281188-0cql96hu	80	27	aureus	aureus	NN
cord-281188-0cql96hu	80	28	,	,	,
cord-281188-0cql96hu	80	29	although	although	IN
cord-281188-0cql96hu	80	30	those	those	DT
cord-281188-0cql96hu	80	31	deemed	deem	VBN
cord-281188-0cql96hu	80	32	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	80	33	killed	kill	VBN
cord-281188-0cql96hu	80	34	at	at	IN
cord-281188-0cql96hu	80	35	a	a	DT
cord-281188-0cql96hu	80	36	lower	low	JJR
cord-281188-0cql96hu	80	37	rate	rate	NN
cord-281188-0cql96hu	80	38	than	than	IN
cord-281188-0cql96hu	80	39	those	those	DT
cord-281188-0cql96hu	80	40	considered	consider	VBN
cord-281188-0cql96hu	80	41	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	80	42	.	.	.
cord-281188-0cql96hu	81	1	Moreover	moreover	RB
cord-281188-0cql96hu	81	2	,	,	,
cord-281188-0cql96hu	81	3	the	the	DT
cord-281188-0cql96hu	81	4	rate	rate	NN
cord-281188-0cql96hu	81	5	at	at	IN
cord-281188-0cql96hu	81	6	which	which	WDT
cord-281188-0cql96hu	81	7	a	a	DT
cord-281188-0cql96hu	81	8	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	81	9	antibiotic	antibiotic	NN
cord-281188-0cql96hu	81	10	kills	kill	VBZ
cord-281188-0cql96hu	81	11	one	one	CD
cord-281188-0cql96hu	81	12	species	species	NN
cord-281188-0cql96hu	81	13	of	of	IN
cord-281188-0cql96hu	81	14	bacteria	bacteria	NNS
cord-281188-0cql96hu	81	15	,	,	,
cord-281188-0cql96hu	81	16	for	for	IN
cord-281188-0cql96hu	81	17	example	example	NN
cord-281188-0cql96hu	81	18	,	,	,
cord-281188-0cql96hu	81	19	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	81	20	coli	coli	NNS
cord-281188-0cql96hu	81	21	,	,	,
cord-281188-0cql96hu	81	22	can	can	MD
cord-281188-0cql96hu	81	23	be	be	VB
cord-281188-0cql96hu	81	24	markedly	markedly	RB
cord-281188-0cql96hu	81	25	less	less	JJR
cord-281188-0cql96hu	81	26	than	than	IN
cord-281188-0cql96hu	81	27	the	the	DT
cord-281188-0cql96hu	81	28	rate	rate	NN
cord-281188-0cql96hu	81	29	at	at	IN
cord-281188-0cql96hu	81	30	which	which	WDT
cord-281188-0cql96hu	81	31	it	-PRON-	PRP
cord-281188-0cql96hu	81	32	kills	kill	VBZ
cord-281188-0cql96hu	81	33	another	another	DT
cord-281188-0cql96hu	81	34	species	species	NN
cord-281188-0cql96hu	81	35	,	,	,
cord-281188-0cql96hu	81	36	for	for	IN
cord-281188-0cql96hu	81	37	example	example	NN
cord-281188-0cql96hu	81	38	,	,	,
cord-281188-0cql96hu	81	39	Campylobacter	Campylobacter	NNP
cord-281188-0cql96hu	81	40	jejuni	jejuni	NNP
cord-281188-0cql96hu	81	41	3	3	CD
cord-281188-0cql96hu	81	42	.	.	.
cord-281188-0cql96hu	82	1	A	a	DT
cord-281188-0cql96hu	82	2	possibility	possibility	NN
cord-281188-0cql96hu	82	3	for	for	IN
cord-281188-0cql96hu	82	4	dealing	deal	VBG
cord-281188-0cql96hu	82	5	with	with	IN
cord-281188-0cql96hu	82	6	this	this	DT
cord-281188-0cql96hu	82	7	conceptual	conceptual	JJ
cord-281188-0cql96hu	82	8	challenge	challenge	NN
cord-281188-0cql96hu	82	9	is	be	VBZ
cord-281188-0cql96hu	82	10	to	to	TO
cord-281188-0cql96hu	82	11	attribute	attribute	VB
cord-281188-0cql96hu	82	12	a	a	DT
cord-281188-0cql96hu	82	13	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	82	14	coefficient	coefficient	NN
cord-281188-0cql96hu	82	15	to	to	IN
cord-281188-0cql96hu	82	16	each	each	DT
cord-281188-0cql96hu	82	17	pair	pair	NN
cord-281188-0cql96hu	82	18	of	of	IN
cord-281188-0cql96hu	82	19	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	82	20	and	and	CC
cord-281188-0cql96hu	82	21	bacterial	bacterial	JJ
cord-281188-0cql96hu	82	22	species	specie	NNS
cord-281188-0cql96hu	82	23	,	,	,
cord-281188-0cql96hu	82	24	considering	consider	VBG
cord-281188-0cql96hu	82	25	the	the	DT
cord-281188-0cql96hu	82	26	amount	amount	NN
cord-281188-0cql96hu	82	27	of	of	IN
cord-281188-0cql96hu	82	28	killing	kill	VBG
cord-281188-0cql96hu	82	29	at	at	IN
cord-281188-0cql96hu	82	30	a	a	DT
cord-281188-0cql96hu	82	31	given	give	VBN
cord-281188-0cql96hu	82	32	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	82	33	concentration	concentration	NN
cord-281188-0cql96hu	82	34	and	and	CC
cord-281188-0cql96hu	82	35	time	time	NN
cord-281188-0cql96hu	82	36	in	in	IN
cord-281188-0cql96hu	82	37	established	establish	VBN
cord-281188-0cql96hu	82	38	standardized	standardized	JJ
cord-281188-0cql96hu	82	39	conditions	condition	NNS
cord-281188-0cql96hu	82	40	.	.	.
cord-281188-0cql96hu	83	1	This	this	DT
cord-281188-0cql96hu	83	2	view	view	NN
cord-281188-0cql96hu	83	3	originated	originate	VBD
cord-281188-0cql96hu	83	4	in	in	IN
cord-281188-0cql96hu	83	5	the	the	DT
cord-281188-0cql96hu	83	6	field	field	NN
cord-281188-0cql96hu	83	7	of	of	IN
cord-281188-0cql96hu	83	8	disinfectants	disinfectant	NNS
cord-281188-0cql96hu	83	9	(	(	-LRB-
cord-281188-0cql96hu	83	10	phenol	phenol	NN
cord-281188-0cql96hu	83	11	coefficient	coefficient	NN
cord-281188-0cql96hu	83	12	,	,	,
cord-281188-0cql96hu	83	13	a	a	DT
cord-281188-0cql96hu	83	14	measure	measure	NN
cord-281188-0cql96hu	83	15	of	of	IN
cord-281188-0cql96hu	83	16	the	the	DT
cord-281188-0cql96hu	83	17	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	83	18	activity	activity	NN
cord-281188-0cql96hu	83	19	of	of	IN
cord-281188-0cql96hu	83	20	a	a	DT
cord-281188-0cql96hu	83	21	chemical	chemical	JJ
cord-281188-0cql96hu	83	22	compound	compound	NN
cord-281188-0cql96hu	83	23	in	in	IN
cord-281188-0cql96hu	83	24	relation	relation	NN
cord-281188-0cql96hu	83	25	to	to	IN
cord-281188-0cql96hu	83	26	phenol	phenol	NN
cord-281188-0cql96hu	83	27	)	)	-RRB-
cord-281188-0cql96hu	83	28	,	,	,
cord-281188-0cql96hu	83	29	and	and	CC
cord-281188-0cql96hu	83	30	the	the	DT
cord-281188-0cql96hu	83	31	calculation	calculation	NN
cord-281188-0cql96hu	83	32	of	of	IN
cord-281188-0cql96hu	83	33	'	'	``
cord-281188-0cql96hu	83	34	specific	specific	JJ
cord-281188-0cql96hu	83	35	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	83	36	activities	activity	NNS
cord-281188-0cql96hu	83	37	'	'	POS
cord-281188-0cql96hu	83	38	(	(	-LRB-
cord-281188-0cql96hu	83	39	SBA	SBA	NNP
cord-281188-0cql96hu	83	40	method	method	NN
cord-281188-0cql96hu	83	41	)	)	-RRB-
cord-281188-0cql96hu	83	42	is	be	VBZ
cord-281188-0cql96hu	83	43	supported	support	VBN
cord-281188-0cql96hu	83	44	by	by	IN
cord-281188-0cql96hu	83	45	the	the	DT
cord-281188-0cql96hu	83	46	National	National	NNP
cord-281188-0cql96hu	83	47	Committee	Committee	NNP
cord-281188-0cql96hu	83	48	for	for	IN
cord-281188-0cql96hu	83	49	Clinical	Clinical	NNP
cord-281188-0cql96hu	83	50	Laboratory	Laboratory	NNP
cord-281188-0cql96hu	83	51	Standards	Standards	NNPS
cord-281188-0cql96hu	83	52	44	44	CD
cord-281188-0cql96hu	83	53	-	-	SYM
cord-281188-0cql96hu	83	54	46	46	CD
cord-281188-0cql96hu	84	1	but	but	CC
cord-281188-0cql96hu	84	2	we	-PRON-	PRP
cord-281188-0cql96hu	84	3	are	be	VBP
cord-281188-0cql96hu	84	4	urging	urge	VBG
cord-281188-0cql96hu	84	5	for	for	IN
cord-281188-0cql96hu	84	6	the	the	DT
cord-281188-0cql96hu	84	7	updating	updating	NN
cord-281188-0cql96hu	84	8	of	of	IN
cord-281188-0cql96hu	84	9	such	such	PDT
cord-281188-0cql96hu	84	10	an	an	DT
cord-281188-0cql96hu	84	11	approach	approach	NN
cord-281188-0cql96hu	84	12	47	47	CD
cord-281188-0cql96hu	84	13	.	.	.
cord-281188-0cql96hu	85	1	Death	death	NN
cord-281188-0cql96hu	85	2	by	by	IN
cord-281188-0cql96hu	85	3	exogenous	exogenous	JJ
cord-281188-0cql96hu	85	4	disruption	disruption	NN
cord-281188-0cql96hu	85	5	of	of	IN
cord-281188-0cql96hu	85	6	cell	cell	NN
cord-281188-0cql96hu	85	7	envelopes	envelope	NNS
cord-281188-0cql96hu	85	8	.	.	.
cord-281188-0cql96hu	86	1	Cell	cell	NN
cord-281188-0cql96hu	86	2	envelopes	envelope	NNS
cord-281188-0cql96hu	86	3	are	be	VBP
cord-281188-0cql96hu	86	4	the	the	DT
cord-281188-0cql96hu	86	5	hallmark	hallmark	NN
cord-281188-0cql96hu	86	6	of	of	IN
cord-281188-0cql96hu	86	7	cellular	cellular	JJ
cord-281188-0cql96hu	86	8	individuality	individuality	NN
cord-281188-0cql96hu	86	9	,	,	,
cord-281188-0cql96hu	86	10	the	the	DT
cord-281188-0cql96hu	86	11	limit	limit	NN
cord-281188-0cql96hu	86	12	between	between	IN
cord-281188-0cql96hu	86	13	the	the	DT
cord-281188-0cql96hu	86	14	'	'	``
cord-281188-0cql96hu	86	15	self	self	NN
cord-281188-0cql96hu	86	16	'	'	''
cord-281188-0cql96hu	86	17	and	and	CC
cord-281188-0cql96hu	86	18	'	'	``
cord-281188-0cql96hu	86	19	non	non	JJ
cord-281188-0cql96hu	86	20	-	-	JJ
cord-281188-0cql96hu	86	21	self	self	JJ
cord-281188-0cql96hu	86	22	'	'	''
cord-281188-0cql96hu	86	23	.	.	.
cord-281188-0cql96hu	87	1	Many	many	JJ
cord-281188-0cql96hu	87	2	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	87	3	agents	agent	NNS
cord-281188-0cql96hu	87	4	kill	kill	VBP
cord-281188-0cql96hu	87	5	cells	cell	NNS
cord-281188-0cql96hu	87	6	by	by	IN
cord-281188-0cql96hu	87	7	direct	direct	JJ
cord-281188-0cql96hu	87	8	disruption	disruption	NN
cord-281188-0cql96hu	87	9	of	of	IN
cord-281188-0cql96hu	87	10	cell	cell	NN
cord-281188-0cql96hu	87	11	envelopes	envelope	NNS
cord-281188-0cql96hu	87	12	48	48	CD
cord-281188-0cql96hu	87	13	.	.	.
cord-281188-0cql96hu	88	1	Of	of	RB
cord-281188-0cql96hu	88	2	course	course	RB
cord-281188-0cql96hu	88	3	,	,	,
cord-281188-0cql96hu	88	4	mechanical	mechanical	JJ
cord-281188-0cql96hu	88	5	disruption	disruption	NN
cord-281188-0cql96hu	88	6	of	of	IN
cord-281188-0cql96hu	88	7	these	these	DT
cord-281188-0cql96hu	88	8	envelopes	envelope	NNS
cord-281188-0cql96hu	88	9	by	by	IN
cord-281188-0cql96hu	88	10	grinding	grind	VBG
cord-281188-0cql96hu	88	11	,	,	,
cord-281188-0cql96hu	88	12	abrasion	abrasion	NN
cord-281188-0cql96hu	88	13	,	,	,
cord-281188-0cql96hu	88	14	high	high	JJ
cord-281188-0cql96hu	88	15	-	-	HYPH
cord-281188-0cql96hu	88	16	pressure	pressure	NN
cord-281188-0cql96hu	88	17	carbon	carbon	NN
cord-281188-0cql96hu	88	18	dioxide	dioxide	NN
cord-281188-0cql96hu	88	19	or	or	CC
cord-281188-0cql96hu	88	20	passing	pass	VBG
cord-281188-0cql96hu	88	21	them	-PRON-	PRP
cord-281188-0cql96hu	88	22	through	through	IN
cord-281188-0cql96hu	88	23	a	a	DT
cord-281188-0cql96hu	88	24	narrow	narrow	JJ
cord-281188-0cql96hu	88	25	valve	valve	NN
cord-281188-0cql96hu	88	26	under	under	IN
cord-281188-0cql96hu	88	27	high	high	JJ
cord-281188-0cql96hu	88	28	pressure	pressure	NN
cord-281188-0cql96hu	88	29	(	(	-LRB-
cord-281188-0cql96hu	88	30	similar	similar	JJ
cord-281188-0cql96hu	88	31	to	to	IN
cord-281188-0cql96hu	88	32	a	a	DT
cord-281188-0cql96hu	88	33	French	french	JJ
cord-281188-0cql96hu	88	34	press	press	NN
cord-281188-0cql96hu	88	35	)	)	-RRB-
cord-281188-0cql96hu	88	36	,	,	,
cord-281188-0cql96hu	88	37	ultrasonication	ultrasonication	NN
cord-281188-0cql96hu	88	38	and	and	CC
cord-281188-0cql96hu	88	39	cavitation	cavitation	NN
cord-281188-0cql96hu	88	40	produces	produce	VBZ
cord-281188-0cql96hu	88	41	Only	only	RB
cord-281188-0cql96hu	88	42	free	free	JJ
cord-281188-0cql96hu	88	43	drug	drug	NN
cord-281188-0cql96hu	88	44	is	be	VBZ
cord-281188-0cql96hu	88	45	active	active	JJ
cord-281188-0cql96hu	88	46	(	(	-LRB-
cord-281188-0cql96hu	88	47	1	1	CD
cord-281188-0cql96hu	88	48	)	)	-RRB-
cord-281188-0cql96hu	88	49	and	and	CC
cord-281188-0cql96hu	88	50	protein	protein	NN
cord-281188-0cql96hu	88	51	binding	binding	NN
cord-281188-0cql96hu	88	52	,	,	,
cord-281188-0cql96hu	88	53	for	for	IN
cord-281188-0cql96hu	88	54	example	example	NN
cord-281188-0cql96hu	88	55	to	to	IN
cord-281188-0cql96hu	88	56	albumin	albumin	NN
cord-281188-0cql96hu	88	57	or	or	CC
cord-281188-0cql96hu	88	58	other	other	JJ
cord-281188-0cql96hu	88	59	plasma	plasma	NN
cord-281188-0cql96hu	88	60	proteins	protein	NNS
cord-281188-0cql96hu	88	61	,	,	,
cord-281188-0cql96hu	88	62	can	can	MD
cord-281188-0cql96hu	88	63	reduce	reduce	VB
cord-281188-0cql96hu	88	64	the	the	DT
cord-281188-0cql96hu	88	65	level	level	NN
cord-281188-0cql96hu	88	66	of	of	IN
cord-281188-0cql96hu	88	67	available	available	JJ
cord-281188-0cql96hu	88	68	and	and	CC
cord-281188-0cql96hu	88	69	thus	thus	RB
cord-281188-0cql96hu	88	70	active	active	JJ
cord-281188-0cql96hu	88	71	drug	drug	NN
cord-281188-0cql96hu	88	72	,	,	,
cord-281188-0cql96hu	88	73	as	as	IN
cord-281188-0cql96hu	88	74	commonly	commonly	RB
cord-281188-0cql96hu	88	75	observed	observe	VBN
cord-281188-0cql96hu	88	76	for	for	IN
cord-281188-0cql96hu	88	77	β	β	NN
cord-281188-0cql96hu	88	78	-	-	HYPH
cord-281188-0cql96hu	88	79	lactams	lactam	NNS
cord-281188-0cql96hu	88	80	.	.	.
cord-281188-0cql96hu	89	1	Uptake	uptake	NN
cord-281188-0cql96hu	89	2	systems	system	NNS
cord-281188-0cql96hu	89	3	(	(	-LRB-
cord-281188-0cql96hu	89	4	such	such	JJ
cord-281188-0cql96hu	89	5	as	as	IN
cord-281188-0cql96hu	89	6	porins	porins	NNP
cord-281188-0cql96hu	89	7	)	)	-RRB-
cord-281188-0cql96hu	89	8	and	and	CC
cord-281188-0cql96hu	89	9	barriers	barrier	NNS
cord-281188-0cql96hu	89	10	can	can	MD
cord-281188-0cql96hu	89	11	prevent	prevent	VB
cord-281188-0cql96hu	89	12	the	the	DT
cord-281188-0cql96hu	89	13	drug	drug	NN
cord-281188-0cql96hu	89	14	from	from	IN
cord-281188-0cql96hu	89	15	entering	enter	VBG
cord-281188-0cql96hu	89	16	cells	cell	NNS
cord-281188-0cql96hu	89	17	(	(	-LRB-
cord-281188-0cql96hu	89	18	2	2	CD
cord-281188-0cql96hu	89	19	)	)	-RRB-
cord-281188-0cql96hu	89	20	or	or	CC
cord-281188-0cql96hu	89	21	the	the	DT
cord-281188-0cql96hu	89	22	drug	drug	NN
cord-281188-0cql96hu	89	23	is	be	VBZ
cord-281188-0cql96hu	89	24	pumped	pump	VBN
cord-281188-0cql96hu	89	25	out	out	RP
cord-281188-0cql96hu	89	26	(	(	-LRB-
cord-281188-0cql96hu	89	27	3	3	CD
cord-281188-0cql96hu	89	28	)	)	-RRB-
cord-281188-0cql96hu	89	29	.	.	.
cord-281188-0cql96hu	90	1	Greater	great	JJR
cord-281188-0cql96hu	90	2	or	or	CC
cord-281188-0cql96hu	90	3	weaker	weak	JJR
cord-281188-0cql96hu	90	4	target	target	NN
cord-281188-0cql96hu	90	5	-	-	HYPH
cord-281188-0cql96hu	90	6	binding	bind	VBG
cord-281188-0cql96hu	90	7	affinity	affinity	NN
cord-281188-0cql96hu	90	8	also	also	RB
cord-281188-0cql96hu	90	9	influences	influence	VBZ
cord-281188-0cql96hu	90	10	activity	activity	NN
cord-281188-0cql96hu	90	11	(	(	-LRB-
cord-281188-0cql96hu	90	12	4	4	CD
cord-281188-0cql96hu	90	13	)	)	-RRB-
cord-281188-0cql96hu	90	14	.	.	.
cord-281188-0cql96hu	91	1	The	the	DT
cord-281188-0cql96hu	91	2	targeted	target	VBN
cord-281188-0cql96hu	91	3	function	function	NN
cord-281188-0cql96hu	91	4	can	can	MD
cord-281188-0cql96hu	91	5	also	also	RB
cord-281188-0cql96hu	91	6	increase	increase	VB
cord-281188-0cql96hu	91	7	in	in	IN
cord-281188-0cql96hu	91	8	the	the	DT
cord-281188-0cql96hu	91	9	presence	presence	NN
cord-281188-0cql96hu	91	10	of	of	IN
cord-281188-0cql96hu	91	11	the	the	DT
cord-281188-0cql96hu	91	12	drug	drug	NN
cord-281188-0cql96hu	91	13	,	,	,
cord-281188-0cql96hu	91	14	thereby	thereby	RB
cord-281188-0cql96hu	91	15	compensating	compensate	VBG
cord-281188-0cql96hu	91	16	for	for	IN
cord-281188-0cql96hu	91	17	inhibition	inhibition	NN
cord-281188-0cql96hu	91	18	(	(	-LRB-
cord-281188-0cql96hu	91	19	5	5	CD
cord-281188-0cql96hu	91	20	;	;	:
cord-281188-0cql96hu	91	21	for	for	IN
cord-281188-0cql96hu	91	22	example	example	NN
cord-281188-0cql96hu	91	23	,	,	,
cord-281188-0cql96hu	91	24	upregulation	upregulation	NN
cord-281188-0cql96hu	91	25	of	of	IN
cord-281188-0cql96hu	91	26	RpoB	RpoB	NNP
cord-281188-0cql96hu	91	27	by	by	IN
cord-281188-0cql96hu	91	28	rifampin	rifampin	NN
cord-281188-0cql96hu	91	29	in	in	IN
cord-281188-0cql96hu	91	30	mycobacteria	mycobacterium	NNS
cord-281188-0cql96hu	91	31	)	)	-RRB-
cord-281188-0cql96hu	91	32	.	.	.
cord-281188-0cql96hu	92	1	The	the	DT
cord-281188-0cql96hu	92	2	target	target	NN
cord-281188-0cql96hu	92	3	function	function	NN
cord-281188-0cql96hu	92	4	involves	involve	VBZ
cord-281188-0cql96hu	92	5	the	the	DT
cord-281188-0cql96hu	92	6	build	build	NN
cord-281188-0cql96hu	92	7	-	-	HYPH
cord-281188-0cql96hu	92	8	up	up	NN
cord-281188-0cql96hu	92	9	of	of	IN
cord-281188-0cql96hu	92	10	a	a	DT
cord-281188-0cql96hu	92	11	cellular	cellular	JJ
cord-281188-0cql96hu	92	12	structure	structure	NN
cord-281188-0cql96hu	92	13	with	with	IN
cord-281188-0cql96hu	92	14	slow	slow	JJ
cord-281188-0cql96hu	92	15	turnover	turnover	NN
cord-281188-0cql96hu	92	16	(	(	-LRB-
cord-281188-0cql96hu	92	17	for	for	IN
cord-281188-0cql96hu	92	18	example	example	NN
cord-281188-0cql96hu	92	19	,	,	,
cord-281188-0cql96hu	92	20	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	92	21	)	)	-RRB-
cord-281188-0cql96hu	92	22	,	,	,
cord-281188-0cql96hu	92	23	which	which	WDT
cord-281188-0cql96hu	92	24	increases	increase	VBZ
cord-281188-0cql96hu	92	25	the	the	DT
cord-281188-0cql96hu	92	26	amount	amount	NN
cord-281188-0cql96hu	92	27	of	of	IN
cord-281188-0cql96hu	92	28	time	time	NN
cord-281188-0cql96hu	92	29	for	for	IN
cord-281188-0cql96hu	92	30	the	the	DT
cord-281188-0cql96hu	92	31	antibiotic	antibiotic	NN
cord-281188-0cql96hu	92	32	to	to	TO
cord-281188-0cql96hu	92	33	kill	kill	VB
cord-281188-0cql96hu	92	34	(	(	-LRB-
cord-281188-0cql96hu	92	35	6	6	CD
cord-281188-0cql96hu	92	36	)	)	-RRB-
cord-281188-0cql96hu	92	37	.	.	.
cord-281188-0cql96hu	93	1	The	the	DT
cord-281188-0cql96hu	93	2	cells	cell	NNS
cord-281188-0cql96hu	93	3	repair	repair	VBP
cord-281188-0cql96hu	93	4	the	the	DT
cord-281188-0cql96hu	93	5	damage	damage	NN
cord-281188-0cql96hu	93	6	produced	produce	VBN
cord-281188-0cql96hu	93	7	by	by	IN
cord-281188-0cql96hu	93	8	the	the	DT
cord-281188-0cql96hu	93	9	drug	drug	NN
cord-281188-0cql96hu	93	10	(	(	-LRB-
cord-281188-0cql96hu	93	11	7	7	CD
cord-281188-0cql96hu	93	12	)	)	-RRB-
cord-281188-0cql96hu	93	13	,	,	,
cord-281188-0cql96hu	93	14	involving	involve	VBG
cord-281188-0cql96hu	93	15	the	the	DT
cord-281188-0cql96hu	93	16	SOS	SOS	NNP
cord-281188-0cql96hu	93	17	system	system	NN
cord-281188-0cql96hu	93	18	.	.	.
cord-281188-0cql96hu	94	1	The	the	DT
cord-281188-0cql96hu	94	2	bacteria	bacteria	NNS
cord-281188-0cql96hu	94	3	have	have	VBP
cord-281188-0cql96hu	94	4	inducible	inducible	JJ
cord-281188-0cql96hu	94	5	antibiotic	antibiotic	RB
cord-281188-0cql96hu	94	6	-	-	HYPH
cord-281188-0cql96hu	94	7	deactivating	deactivate	VBG
cord-281188-0cql96hu	94	8	mechanisms	mechanism	NNS
cord-281188-0cql96hu	94	9	(	(	-LRB-
cord-281188-0cql96hu	94	10	8	8	CD
cord-281188-0cql96hu	94	11	;	;	:
cord-281188-0cql96hu	94	12	for	for	IN
cord-281188-0cql96hu	94	13	example	example	NN
cord-281188-0cql96hu	94	14	,	,	,
cord-281188-0cql96hu	94	15	β	β	NN
cord-281188-0cql96hu	94	16	-	-	HYPH
cord-281188-0cql96hu	94	17	lactamases	lactamases	NNP
cord-281188-0cql96hu	94	18	)	)	-RRB-
cord-281188-0cql96hu	94	19	.	.	.
cord-281188-0cql96hu	95	1	The	the	DT
cord-281188-0cql96hu	95	2	bacteria	bacteria	NNS
cord-281188-0cql96hu	95	3	use	use	VBP
cord-281188-0cql96hu	95	4	alternative	alternative	JJ
cord-281188-0cql96hu	95	5	functions	function	NNS
cord-281188-0cql96hu	95	6	,	,	,
cord-281188-0cql96hu	95	7	bypassing	bypass	VBG
cord-281188-0cql96hu	95	8	those	those	DT
cord-281188-0cql96hu	95	9	that	that	WDT
cord-281188-0cql96hu	95	10	are	be	VBP
cord-281188-0cql96hu	95	11	inhibited	inhibit	VBN
cord-281188-0cql96hu	95	12	(	(	-LRB-
cord-281188-0cql96hu	95	13	9	9	CD
cord-281188-0cql96hu	95	14	)	)	-RRB-
cord-281188-0cql96hu	95	15	.	.	.
cord-281188-0cql96hu	96	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	96	2	differ	differ	VBP
cord-281188-0cql96hu	96	3	in	in	IN
cord-281188-0cql96hu	96	4	the	the	DT
cord-281188-0cql96hu	96	5	extent	extent	NN
cord-281188-0cql96hu	96	6	to	to	TO
cord-281188-0cql96hu	96	7	which	which	WDT
cord-281188-0cql96hu	96	8	they	-PRON-	PRP
cord-281188-0cql96hu	96	9	induce	induce	VBP
cord-281188-0cql96hu	96	10	reactive	reactive	JJ
cord-281188-0cql96hu	96	11	oxygen	oxygen	NN
cord-281188-0cql96hu	96	12	species	specie	NNS
cord-281188-0cql96hu	96	13	(	(	-LRB-
cord-281188-0cql96hu	96	14	ROS	ROS	NNP
cord-281188-0cql96hu	96	15	;	;	:
cord-281188-0cql96hu	96	16	deleterious	deleterious	JJ
cord-281188-0cql96hu	96	17	)	)	-RRB-
cord-281188-0cql96hu	96	18	or	or	CC
cord-281188-0cql96hu	96	19	SOS	SOS	NNP
cord-281188-0cql96hu	96	20	(	(	-LRB-
cord-281188-0cql96hu	96	21	potentially	potentially	RB
cord-281188-0cql96hu	96	22	protective	protective	JJ
cord-281188-0cql96hu	96	23	)	)	-RRB-
cord-281188-0cql96hu	96	24	responses	response	NNS
cord-281188-0cql96hu	96	25	(	(	-LRB-
cord-281188-0cql96hu	96	26	10	10	CD
cord-281188-0cql96hu	96	27	)	)	-RRB-
cord-281188-0cql96hu	96	28	.	.	.
cord-281188-0cql96hu	97	1	Low	low	JJ
cord-281188-0cql96hu	97	2	replication	replication	NN
cord-281188-0cql96hu	97	3	rates	rate	NNS
cord-281188-0cql96hu	97	4	(	(	-LRB-
cord-281188-0cql96hu	97	5	involving	involve	VBG
cord-281188-0cql96hu	97	6	the	the	DT
cord-281188-0cql96hu	97	7	SOS	SOS	NNP
cord-281188-0cql96hu	97	8	system	system	NN
cord-281188-0cql96hu	97	9	)	)	-RRB-
cord-281188-0cql96hu	97	10	reduce	reduce	VB
cord-281188-0cql96hu	97	11	the	the	DT
cord-281188-0cql96hu	97	12	killing	killing	NN
cord-281188-0cql96hu	97	13	activity	activity	NN
cord-281188-0cql96hu	97	14	(	(	-LRB-
cord-281188-0cql96hu	97	15	11	11	CD
cord-281188-0cql96hu	97	16	)	)	-RRB-
cord-281188-0cql96hu	97	17	.	.	.
cord-281188-0cql96hu	98	1	Activation	activation	NN
cord-281188-0cql96hu	98	2	of	of	IN
cord-281188-0cql96hu	98	3	the	the	DT
cord-281188-0cql96hu	98	4	RpoS	RpoS	NNP
cord-281188-0cql96hu	98	5	-	-	HYPH
cord-281188-0cql96hu	98	6	mediated	mediate	VBN
cord-281188-0cql96hu	98	7	stringent	stringent	JJ
cord-281188-0cql96hu	98	8	response	response	NN
cord-281188-0cql96hu	98	9	produces	produce	VBZ
cord-281188-0cql96hu	98	10	a	a	DT
cord-281188-0cql96hu	98	11	kind	kind	NN
cord-281188-0cql96hu	98	12	of	of	IN
cord-281188-0cql96hu	98	13	'	'	``
cord-281188-0cql96hu	98	14	stationary	stationary	JJ
cord-281188-0cql96hu	98	15	phase	phase	NN
cord-281188-0cql96hu	98	16	'	'	''
cord-281188-0cql96hu	98	17	,	,	,
cord-281188-0cql96hu	98	18	reducing	reduce	VBG
cord-281188-0cql96hu	98	19	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	98	20	potency	potency	NN
cord-281188-0cql96hu	98	21	(	(	-LRB-
cord-281188-0cql96hu	98	22	12	12	CD
cord-281188-0cql96hu	98	23	)	)	-RRB-
cord-281188-0cql96hu	98	24	.	.	.
cord-281188-0cql96hu	99	1	The	the	DT
cord-281188-0cql96hu	99	2	two	two	CD
cord-281188-0cql96hu	99	3	ultimate	ultimate	JJ
cord-281188-0cql96hu	99	4	causes	cause	NNS
cord-281188-0cql96hu	99	5	(	(	-LRB-
cord-281188-0cql96hu	99	6	bottom	bottom	NN
cord-281188-0cql96hu	99	7	right	right	RB
cord-281188-0cql96hu	99	8	)	)	-RRB-
cord-281188-0cql96hu	99	9	of	of	IN
cord-281188-0cql96hu	99	10	a	a	DT
cord-281188-0cql96hu	99	11	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	99	12	effect	effect	NN
cord-281188-0cql96hu	99	13	are	be	VBP
cord-281188-0cql96hu	99	14	loss	loss	NN
cord-281188-0cql96hu	99	15	of	of	IN
cord-281188-0cql96hu	99	16	spatial	spatial	JJ
cord-281188-0cql96hu	99	17	individuality	individuality	NN
cord-281188-0cql96hu	99	18	by	by	IN
cord-281188-0cql96hu	99	19	rupture	rupture	NN
cord-281188-0cql96hu	99	20	of	of	IN
cord-281188-0cql96hu	99	21	the	the	DT
cord-281188-0cql96hu	99	22	limits	limit	NNS
cord-281188-0cql96hu	99	23	with	with	IN
cord-281188-0cql96hu	99	24	the	the	DT
cord-281188-0cql96hu	99	25	environment	environment	NN
cord-281188-0cql96hu	99	26	(	(	-LRB-
cord-281188-0cql96hu	99	27	broken	break	VBN
cord-281188-0cql96hu	99	28	green	green	JJ
cord-281188-0cql96hu	99	29	line	line	NN
cord-281188-0cql96hu	99	30	indicating	indicate	VBG
cord-281188-0cql96hu	99	31	disruption	disruption	NN
cord-281188-0cql96hu	99	32	of	of	IN
cord-281188-0cql96hu	99	33	the	the	DT
cord-281188-0cql96hu	99	34	cell	cell	NN
cord-281188-0cql96hu	99	35	envelope	envelope	NN
cord-281188-0cql96hu	99	36	)	)	-RRB-
cord-281188-0cql96hu	99	37	and	and	CC
cord-281188-0cql96hu	99	38	loss	loss	NN
cord-281188-0cql96hu	99	39	of	of	IN
cord-281188-0cql96hu	99	40	genetic	genetic	JJ
cord-281188-0cql96hu	99	41	individuality	individuality	NN
cord-281188-0cql96hu	99	42	(	(	-LRB-
cord-281188-0cql96hu	99	43	broken	break	VBN
cord-281188-0cql96hu	99	44	blue	blue	JJ
cord-281188-0cql96hu	99	45	line	line	NN
cord-281188-0cql96hu	99	46	indicating	indicate	VBG
cord-281188-0cql96hu	99	47	disruption	disruption	NN
cord-281188-0cql96hu	99	48	of	of	IN
cord-281188-0cql96hu	99	49	the	the	DT
cord-281188-0cql96hu	99	50	genome	genome	NN
cord-281188-0cql96hu	99	51	)	)	-RRB-
cord-281188-0cql96hu	99	52	.	.	.
cord-281188-0cql96hu	100	1	rapid	rapid	JJ
cord-281188-0cql96hu	100	2	bacterial	bacterial	JJ
cord-281188-0cql96hu	100	3	death	death	NN
cord-281188-0cql96hu	100	4	49	49	CD
cord-281188-0cql96hu	100	5	.	.	.
cord-281188-0cql96hu	101	1	Other	other	JJ
cord-281188-0cql96hu	101	2	physical	physical	JJ
cord-281188-0cql96hu	101	3	destructuring	destructuring	NN
cord-281188-0cql96hu	101	4	methods	method	NNS
cord-281188-0cql96hu	101	5	include	include	VBP
cord-281188-0cql96hu	101	6	use	use	NN
cord-281188-0cql96hu	101	7	of	of	IN
cord-281188-0cql96hu	101	8	dry	dry	JJ
cord-281188-0cql96hu	101	9	ice	ice	NN
cord-281188-0cql96hu	101	10	with	with	IN
cord-281188-0cql96hu	101	11	ethanol	ethanol	NN
cord-281188-0cql96hu	101	12	,	,	,
cord-281188-0cql96hu	101	13	boiling	boiling	NN
cord-281188-0cql96hu	101	14	,	,	,
cord-281188-0cql96hu	101	15	osmotic	osmotic	JJ
cord-281188-0cql96hu	101	16	or	or	CC
cord-281188-0cql96hu	101	17	hydrostatic	hydrostatic	JJ
cord-281188-0cql96hu	101	18	pressure	pressure	NN
cord-281188-0cql96hu	101	19	and	and	CC
cord-281188-0cql96hu	101	20	extreme	extreme	JJ
cord-281188-0cql96hu	101	21	pH	ph	NN
cord-281188-0cql96hu	101	22	values	value	NNS
cord-281188-0cql96hu	101	23	.	.	.
cord-281188-0cql96hu	102	1	Chemical	chemical	NN
cord-281188-0cql96hu	102	2	disruptors	disruptor	NNS
cord-281188-0cql96hu	102	3	of	of	IN
cord-281188-0cql96hu	102	4	cell	cell	NN
cord-281188-0cql96hu	102	5	envelopes	envelope	NNS
cord-281188-0cql96hu	102	6	include	include	VBP
cord-281188-0cql96hu	102	7	detergents	detergent	NNS
cord-281188-0cql96hu	102	8	,	,	,
cord-281188-0cql96hu	102	9	biocides	biocide	NNS
cord-281188-0cql96hu	102	10	,	,	,
cord-281188-0cql96hu	102	11	halogens	halogen	NNS
cord-281188-0cql96hu	102	12	and	and	CC
cord-281188-0cql96hu	102	13	toxic	toxic	JJ
cord-281188-0cql96hu	102	14	gases	gas	NNS
cord-281188-0cql96hu	102	15	50	50	CD
cord-281188-0cql96hu	102	16	.	.	.
cord-281188-0cql96hu	103	1	More	more	RBR
cord-281188-0cql96hu	103	2	similar	similar	JJ
cord-281188-0cql96hu	103	3	to	to	IN
cord-281188-0cql96hu	103	4	therapeutic	therapeutic	JJ
cord-281188-0cql96hu	103	5	antimicrobials	antimicrobial	NNS
cord-281188-0cql96hu	103	6	are	be	VBP
cord-281188-0cql96hu	103	7	cell	cell	NN
cord-281188-0cql96hu	103	8	wall	wall	NN
cord-281188-0cql96hu	103	9	-	-	HYPH
cord-281188-0cql96hu	103	10	destroying	destroy	VBG
cord-281188-0cql96hu	103	11	enzymes	enzyme	NNS
cord-281188-0cql96hu	103	12	,	,	,
cord-281188-0cql96hu	103	13	bacteriocins	bacteriocin	NNS
cord-281188-0cql96hu	103	14	and	and	CC
cord-281188-0cql96hu	103	15	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	103	16	peptides	peptide	NNS
cord-281188-0cql96hu	103	17	,	,	,
cord-281188-0cql96hu	103	18	including	include	VBG
cord-281188-0cql96hu	103	19	host	host	NN
cord-281188-0cql96hu	103	20	defence	defence	NN
cord-281188-0cql96hu	103	21	peptides	peptide	NNS
cord-281188-0cql96hu	103	22	of	of	IN
cord-281188-0cql96hu	103	23	insects	insect	NNS
cord-281188-0cql96hu	103	24	,	,	,
cord-281188-0cql96hu	103	25	reptiles	reptile	NNS
cord-281188-0cql96hu	103	26	or	or	CC
cord-281188-0cql96hu	103	27	higher	high	JJR
cord-281188-0cql96hu	103	28	animals	animal	NNS
cord-281188-0cql96hu	103	29	(	(	-LRB-
cord-281188-0cql96hu	103	30	for	for	IN
cord-281188-0cql96hu	103	31	example	example	NN
cord-281188-0cql96hu	103	32	,	,	,
cord-281188-0cql96hu	103	33	cecropins	cecropin	NNS
cord-281188-0cql96hu	103	34	,	,	,
cord-281188-0cql96hu	103	35	magainins	magainins	NNP
cord-281188-0cql96hu	103	36	and	and	CC
cord-281188-0cql96hu	103	37	defensins	defensins	NNP
cord-281188-0cql96hu	103	38	)	)	-RRB-
cord-281188-0cql96hu	103	39	.	.	.
cord-281188-0cql96hu	104	1	These	these	DT
cord-281188-0cql96hu	104	2	agents	agent	NNS
cord-281188-0cql96hu	104	3	rapidly	rapidly	RB
cord-281188-0cql96hu	104	4	kill	kill	VBP
cord-281188-0cql96hu	104	5	bacteria	bacteria	NNS
cord-281188-0cql96hu	104	6	by	by	IN
cord-281188-0cql96hu	104	7	producing	produce	VBG
cord-281188-0cql96hu	104	8	holes	hole	NNS
cord-281188-0cql96hu	104	9	in	in	IN
cord-281188-0cql96hu	104	10	their	-PRON-	PRP$
cord-281188-0cql96hu	104	11	envelopes	envelope	NNS
cord-281188-0cql96hu	104	12	(	(	-LRB-
cord-281188-0cql96hu	104	13	particularly	particularly	RB
cord-281188-0cql96hu	104	14	the	the	DT
cord-281188-0cql96hu	104	15	cellular	cellular	JJ
cord-281188-0cql96hu	104	16	membrane	membrane	NN
cord-281188-0cql96hu	104	17	)	)	-RRB-
cord-281188-0cql96hu	104	18	.	.	.
cord-281188-0cql96hu	105	1	A	a	DT
cord-281188-0cql96hu	105	2	number	number	NN
cord-281188-0cql96hu	105	3	of	of	IN
cord-281188-0cql96hu	105	4	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	105	5	that	that	WDT
cord-281188-0cql96hu	105	6	are	be	VBP
cord-281188-0cql96hu	105	7	used	use	VBN
cord-281188-0cql96hu	105	8	clinically	clinically	RB
cord-281188-0cql96hu	105	9	,	,	,
cord-281188-0cql96hu	105	10	such	such	JJ
cord-281188-0cql96hu	105	11	as	as	IN
cord-281188-0cql96hu	105	12	the	the	DT
cord-281188-0cql96hu	105	13	cyclic	cyclic	JJ
cord-281188-0cql96hu	105	14	peptides	peptide	NNS
cord-281188-0cql96hu	105	15	(	(	-LRB-
cord-281188-0cql96hu	105	16	polymyxin	polymyxin	NNP
cord-281188-0cql96hu	105	17	B	B	NNP
cord-281188-0cql96hu	105	18	and	and	CC
cord-281188-0cql96hu	105	19	colistin	colistin	NNP
cord-281188-0cql96hu	105	20	)	)	-RRB-
cord-281188-0cql96hu	105	21	and	and	CC
cord-281188-0cql96hu	105	22	lipopeptides	lipopeptides	NNP
cord-281188-0cql96hu	105	23	(	(	-LRB-
cord-281188-0cql96hu	105	24	telavancin	telavancin	NNS
cord-281188-0cql96hu	105	25	and	and	CC
cord-281188-0cql96hu	105	26	daptomycin	daptomycin	NNP
cord-281188-0cql96hu	105	27	)	)	-RRB-
cord-281188-0cql96hu	105	28	,	,	,
cord-281188-0cql96hu	105	29	kill	kill	VB
cord-281188-0cql96hu	105	30	by	by	IN
cord-281188-0cql96hu	105	31	disrupting	disrupt	VBG
cord-281188-0cql96hu	105	32	cell	cell	NN
cord-281188-0cql96hu	105	33	membranes	membrane	NNS
cord-281188-0cql96hu	105	34	.	.	.
cord-281188-0cql96hu	106	1	Similarly	similarly	RB
cord-281188-0cql96hu	106	2	to	to	IN
cord-281188-0cql96hu	106	3	that	that	DT
cord-281188-0cql96hu	106	4	of	of	IN
cord-281188-0cql96hu	106	5	detergents	detergent	NNS
cord-281188-0cql96hu	106	6	,	,	,
cord-281188-0cql96hu	106	7	the	the	DT
cord-281188-0cql96hu	106	8	killing	kill	VBG
cord-281188-0cql96hu	106	9	action	action	NN
cord-281188-0cql96hu	106	10	of	of	IN
cord-281188-0cql96hu	106	11	these	these	DT
cord-281188-0cql96hu	106	12	agents	agent	NNS
cord-281188-0cql96hu	106	13	may	may	MD
cord-281188-0cql96hu	106	14	be	be	VB
cord-281188-0cql96hu	106	15	better	well	RBR
cord-281188-0cql96hu	106	16	described	describe	VBN
cord-281188-0cql96hu	106	17	as	as	IN
cord-281188-0cql96hu	106	18	'	'	``
cord-281188-0cql96hu	106	19	physical	physical	JJ
cord-281188-0cql96hu	106	20	'	'	''
cord-281188-0cql96hu	106	21	rather	rather	RB
cord-281188-0cql96hu	106	22	than	than	IN
cord-281188-0cql96hu	106	23	biological	biological	JJ
cord-281188-0cql96hu	106	24	.	.	.
cord-281188-0cql96hu	107	1	At	at	IN
cord-281188-0cql96hu	107	2	low	low	JJ
cord-281188-0cql96hu	107	3	concentrations	concentration	NNS
cord-281188-0cql96hu	107	4	of	of	IN
cord-281188-0cql96hu	107	5	these	these	DT
cord-281188-0cql96hu	107	6	agents	agent	NNS
cord-281188-0cql96hu	107	7	,	,	,
cord-281188-0cql96hu	107	8	bacteria	bacteria	NNS
cord-281188-0cql96hu	107	9	can	can	MD
cord-281188-0cql96hu	107	10	compensate	compensate	VB
cord-281188-0cql96hu	107	11	or	or	CC
cord-281188-0cql96hu	107	12	repair	repair	VB
cord-281188-0cql96hu	107	13	the	the	DT
cord-281188-0cql96hu	107	14	resulting	result	VBG
cord-281188-0cql96hu	107	15	damage	damage	NN
cord-281188-0cql96hu	107	16	and	and	CC
cord-281188-0cql96hu	107	17	they	-PRON-	PRP
cord-281188-0cql96hu	107	18	can	can	MD
cord-281188-0cql96hu	107	19	replicate	replicate	VB
cord-281188-0cql96hu	107	20	at	at	IN
cord-281188-0cql96hu	107	21	a	a	DT
cord-281188-0cql96hu	107	22	rate	rate	NN
cord-281188-0cql96hu	107	23	that	that	WDT
cord-281188-0cql96hu	107	24	exceeds	exceed	VBZ
cord-281188-0cql96hu	107	25	the	the	DT
cord-281188-0cql96hu	107	26	killing	killing	NN
cord-281188-0cql96hu	107	27	rate	rate	NN
cord-281188-0cql96hu	107	28	.	.	.
cord-281188-0cql96hu	108	1	Bacteria	Bacteria	NNS
cord-281188-0cql96hu	108	2	can	can	MD
cord-281188-0cql96hu	108	3	commit	commit	VB
cord-281188-0cql96hu	108	4	suicide	suicide	NN
cord-281188-0cql96hu	108	5	by	by	IN
cord-281188-0cql96hu	108	6	disrupting	disrupt	VBG
cord-281188-0cql96hu	108	7	their	-PRON-	PRP$
cord-281188-0cql96hu	108	8	cell	cell	NN
cord-281188-0cql96hu	108	9	envelopes	envelope	NNS
cord-281188-0cql96hu	108	10	,	,	,
cord-281188-0cql96hu	108	11	leading	lead	VBG
cord-281188-0cql96hu	108	12	to	to	IN
cord-281188-0cql96hu	108	13	stiffness	stiffness	NN
cord-281188-0cql96hu	108	14	,	,	,
cord-281188-0cql96hu	108	15	strength	strength	NN
cord-281188-0cql96hu	108	16	loss	loss	NN
cord-281188-0cql96hu	108	17	and	and	CC
cord-281188-0cql96hu	108	18	osmotic	osmotic	JJ
cord-281188-0cql96hu	108	19	lysis	lysis	NN
cord-281188-0cql96hu	108	20	.	.	.
cord-281188-0cql96hu	109	1	Autolysins	Autolysins	NNP
cord-281188-0cql96hu	109	2	,	,	,
cord-281188-0cql96hu	109	3	first	first	RB
cord-281188-0cql96hu	109	4	studied	study	VBN
cord-281188-0cql96hu	109	5	in	in	IN
cord-281188-0cql96hu	109	6	Streptococcus	Streptococcus	NNP
cord-281188-0cql96hu	109	7	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	109	8	,	,	,
cord-281188-0cql96hu	109	9	are	be	VBP
cord-281188-0cql96hu	109	10	enzymes	enzyme	NNS
cord-281188-0cql96hu	109	11	that	that	WDT
cord-281188-0cql96hu	109	12	degrade	degrade	VBP
cord-281188-0cql96hu	109	13	the	the	DT
cord-281188-0cql96hu	109	14	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	109	15	(	(	-LRB-
cord-281188-0cql96hu	109	16	cell	cell	NN
cord-281188-0cql96hu	109	17	wall	wall	NN
cord-281188-0cql96hu	109	18	)	)	-RRB-
cord-281188-0cql96hu	109	19	substrate	substrate	NN
cord-281188-0cql96hu	109	20	and	and	CC
cord-281188-0cql96hu	109	21	include	include	VBP
cord-281188-0cql96hu	109	22	glycosidases	glycosidases	NNP
cord-281188-0cql96hu	109	23	(	(	-LRB-
cord-281188-0cql96hu	109	24	muramidases	muramidases	NNP
cord-281188-0cql96hu	109	25	,	,	,
cord-281188-0cql96hu	109	26	as	as	IN
cord-281188-0cql96hu	109	27	LytA	LytA	NNP
cord-281188-0cql96hu	109	28	,	,	,
cord-281188-0cql96hu	109	29	lysozymes	lysozymes	NNP
cord-281188-0cql96hu	109	30	,	,	,
cord-281188-0cql96hu	109	31	glucosaminidases	glucosaminidases	NNP
cord-281188-0cql96hu	109	32	and	and	CC
cord-281188-0cql96hu	109	33	transglycosylases	transglycosylases	NNP
cord-281188-0cql96hu	109	34	)	)	-RRB-
cord-281188-0cql96hu	109	35	,	,	,
cord-281188-0cql96hu	109	36	amidases	amidases	NNP
cord-281188-0cql96hu	109	37	and	and	CC
cord-281188-0cql96hu	109	38	endopeptidases	endopeptidase	VBZ
cord-281188-0cql96hu	109	39	51	51	CD
cord-281188-0cql96hu	109	40	,	,	,
cord-281188-0cql96hu	109	41	52	52	CD
cord-281188-0cql96hu	109	42	.	.	.
cord-281188-0cql96hu	110	1	The	the	DT
cord-281188-0cql96hu	110	2	cidABC	cidabc	NN
cord-281188-0cql96hu	110	3	and	and	CC
cord-281188-0cql96hu	110	4	lrgAB	lrgAB	NNP
cord-281188-0cql96hu	110	5	operons	operon	NNS
cord-281188-0cql96hu	110	6	of	of	IN
cord-281188-0cql96hu	110	7	S.	S.	NNP
cord-281188-0cql96hu	110	8	aureus	aureu	NNS
cord-281188-0cql96hu	110	9	have	have	VBP
cord-281188-0cql96hu	110	10	been	be	VBN
cord-281188-0cql96hu	110	11	shown	show	VBN
cord-281188-0cql96hu	110	12	to	to	TO
cord-281188-0cql96hu	110	13	influence	influence	VB
cord-281188-0cql96hu	110	14	bacterial	bacterial	JJ
cord-281188-0cql96hu	110	15	death	death	NN
cord-281188-0cql96hu	110	16	by	by	IN
cord-281188-0cql96hu	110	17	posttranslational	posttranslational	JJ
cord-281188-0cql96hu	110	18	regulation	regulation	NN
cord-281188-0cql96hu	110	19	of	of	IN
cord-281188-0cql96hu	110	20	peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	110	21	hydrolase	hydrolase	NNP
cord-281188-0cql96hu	110	22	activity	activity	NN
cord-281188-0cql96hu	110	23	53	53	CD
cord-281188-0cql96hu	110	24	.	.	.
cord-281188-0cql96hu	111	1	In	in	IN
cord-281188-0cql96hu	111	2	all	all	PDT
cord-281188-0cql96hu	111	3	these	these	DT
cord-281188-0cql96hu	111	4	cases	case	NNS
cord-281188-0cql96hu	111	5	,	,	,
cord-281188-0cql96hu	111	6	as	as	RB
cord-281188-0cql96hu	111	7	well	well	RB
cord-281188-0cql96hu	111	8	as	as	IN
cord-281188-0cql96hu	111	9	in	in	IN
cord-281188-0cql96hu	111	10	E.	E.	NNP
cord-281188-0cql96hu	111	11	coli	coli	NNS
cord-281188-0cql96hu	111	12	,	,	,
cord-281188-0cql96hu	111	13	β	β	NN
cord-281188-0cql96hu	111	14	-	-	HYPH
cord-281188-0cql96hu	111	15	lactams	lactams	NNP
cord-281188-0cql96hu	111	16	trigger	trigger	VBP
cord-281188-0cql96hu	111	17	autolysin	autolysin	NNP
cord-281188-0cql96hu	111	18	release	release	NN
cord-281188-0cql96hu	111	19	by	by	IN
cord-281188-0cql96hu	111	20	disturbing	disturb	VBG
cord-281188-0cql96hu	111	21	the	the	DT
cord-281188-0cql96hu	111	22	balance	balance	NN
cord-281188-0cql96hu	111	23	between	between	IN
cord-281188-0cql96hu	111	24	peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	111	25	synthesis	synthesis	NN
cord-281188-0cql96hu	111	26	and	and	CC
cord-281188-0cql96hu	111	27	hydrolysis	hydrolysis	NN
cord-281188-0cql96hu	111	28	,	,	,
cord-281188-0cql96hu	111	29	which	which	WDT
cord-281188-0cql96hu	111	30	is	be	VBZ
cord-281188-0cql96hu	111	31	necessary	necessary	JJ
cord-281188-0cql96hu	111	32	for	for	IN
cord-281188-0cql96hu	111	33	growth	growth	NN
cord-281188-0cql96hu	111	34	of	of	IN
cord-281188-0cql96hu	111	35	the	the	DT
cord-281188-0cql96hu	111	36	cell	cell	NN
cord-281188-0cql96hu	111	37	wall	wall	NN
cord-281188-0cql96hu	111	38	54	54	CD
cord-281188-0cql96hu	111	39	.	.	.
cord-281188-0cql96hu	112	1	Bacterial	bacterial	JJ
cord-281188-0cql96hu	112	2	growth	growth	NN
cord-281188-0cql96hu	112	3	requires	require	VBZ
cord-281188-0cql96hu	112	4	constant	constant	JJ
cord-281188-0cql96hu	112	5	synthesis	synthesis	NN
cord-281188-0cql96hu	112	6	and	and	CC
cord-281188-0cql96hu	112	7	turnover	turnover	NN
cord-281188-0cql96hu	112	8	of	of	IN
cord-281188-0cql96hu	112	9	the	the	DT
cord-281188-0cql96hu	112	10	cell	cell	NN
cord-281188-0cql96hu	112	11	wall	wall	NN
cord-281188-0cql96hu	112	12	to	to	TO
cord-281188-0cql96hu	112	13	insert	insert	VB
cord-281188-0cql96hu	112	14	new	new	JJ
cord-281188-0cql96hu	112	15	molecules	molecule	NNS
cord-281188-0cql96hu	112	16	,	,	,
cord-281188-0cql96hu	112	17	and	and	CC
cord-281188-0cql96hu	112	18	the	the	DT
cord-281188-0cql96hu	112	19	latter	latter	JJ
cord-281188-0cql96hu	112	20	process	process	NN
cord-281188-0cql96hu	112	21	relies	rely	VBZ
cord-281188-0cql96hu	112	22	on	on	IN
cord-281188-0cql96hu	112	23	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	112	24	cleavage	cleavage	NN
cord-281188-0cql96hu	112	25	enzymes	enzyme	NNS
cord-281188-0cql96hu	112	26	,	,	,
cord-281188-0cql96hu	112	27	including	include	VBG
cord-281188-0cql96hu	112	28	glycosidases	glycosidase	NNS
cord-281188-0cql96hu	112	29	,	,	,
cord-281188-0cql96hu	112	30	amidases	amidases	NNP
cord-281188-0cql96hu	112	31	and	and	CC
cord-281188-0cql96hu	112	32	endopeptidases	endopeptidase	VBZ
cord-281188-0cql96hu	112	33	55	55	CD
cord-281188-0cql96hu	112	34	.	.	.
cord-281188-0cql96hu	113	1	The	the	DT
cord-281188-0cql96hu	113	2	same	same	JJ
cord-281188-0cql96hu	113	3	enzymes	enzyme	NNS
cord-281188-0cql96hu	113	4	can	can	MD
cord-281188-0cql96hu	113	5	produce	produce	VB
cord-281188-0cql96hu	113	6	lethal	lethal	JJ
cord-281188-0cql96hu	113	7	damage	damage	NN
cord-281188-0cql96hu	114	1	-the	-the	NFP
cord-281188-0cql96hu	115	1	physiology	physiology	NN
cord-281188-0cql96hu	115	2	of	of	IN
cord-281188-0cql96hu	115	3	growth	growth	NN
cord-281188-0cql96hu	115	4	can	can	MD
cord-281188-0cql96hu	115	5	be	be	VB
cord-281188-0cql96hu	115	6	converted	convert	VBN
cord-281188-0cql96hu	115	7	into	into	IN
cord-281188-0cql96hu	115	8	the	the	DT
cord-281188-0cql96hu	115	9	physiology	physiology	NN
cord-281188-0cql96hu	115	10	of	of	IN
cord-281188-0cql96hu	115	11	death	death	NN
cord-281188-0cql96hu	115	12	.	.	.
cord-281188-0cql96hu	116	1	The	the	DT
cord-281188-0cql96hu	116	2	effect	effect	NN
cord-281188-0cql96hu	116	3	of	of	IN
cord-281188-0cql96hu	116	4	autolytic	autolytic	JJ
cord-281188-0cql96hu	116	5	enzymes	enzyme	NNS
cord-281188-0cql96hu	116	6	seems	seem	VBZ
cord-281188-0cql96hu	116	7	to	to	TO
cord-281188-0cql96hu	116	8	depend	depend	VB
cord-281188-0cql96hu	116	9	on	on	IN
cord-281188-0cql96hu	116	10	teichoic	teichoic	NN
cord-281188-0cql96hu	116	11	acids	acid	NNS
cord-281188-0cql96hu	116	12	in	in	IN
cord-281188-0cql96hu	116	13	Grampositive	Grampositive	NNP
cord-281188-0cql96hu	116	14	bacteria	bacteria	NNS
cord-281188-0cql96hu	116	15	(	(	-LRB-
cord-281188-0cql96hu	116	16	at	at	IN
cord-281188-0cql96hu	116	17	least	least	JJS
cord-281188-0cql96hu	116	18	in	in	IN
cord-281188-0cql96hu	116	19	S.	S.	NNP
cord-281188-0cql96hu	116	20	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	116	21	)	)	-RRB-
cord-281188-0cql96hu	116	22	and	and	CC
cord-281188-0cql96hu	116	23	on	on	IN
cord-281188-0cql96hu	116	24	lipopolysaccharides	lipopolysaccharides	NNP
cord-281188-0cql96hu	116	25	(	(	-LRB-
cord-281188-0cql96hu	116	26	LPS	LPS	NNP
cord-281188-0cql96hu	116	27	)	)	-RRB-
cord-281188-0cql96hu	116	28	in	in	IN
cord-281188-0cql96hu	116	29	Gram	gram	NN
cord-281188-0cql96hu	116	30	-	-	HYPH
cord-281188-0cql96hu	116	31	negative	negative	JJ
cord-281188-0cql96hu	116	32	bacteria	bacteria	NNS
cord-281188-0cql96hu	116	33	.	.	.
cord-281188-0cql96hu	117	1	The	the	DT
cord-281188-0cql96hu	117	2	mechanism	mechanism	NN
cord-281188-0cql96hu	117	3	of	of	IN
cord-281188-0cql96hu	117	4	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	117	5	induction	induction	NN
cord-281188-0cql96hu	117	6	of	of	IN
cord-281188-0cql96hu	117	7	autolysins	autolysins	NNP
cord-281188-0cql96hu	117	8	,	,	,
cord-281188-0cql96hu	117	9	as	as	IN
cord-281188-0cql96hu	117	10	shown	show	VBN
cord-281188-0cql96hu	117	11	in	in	IN
cord-281188-0cql96hu	117	12	S.	S.	NNP
cord-281188-0cql96hu	117	13	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	117	14	,	,	,
cord-281188-0cql96hu	117	15	is	be	VBZ
cord-281188-0cql96hu	117	16	based	base	VBN
cord-281188-0cql96hu	117	17	on	on	IN
cord-281188-0cql96hu	117	18	the	the	DT
cord-281188-0cql96hu	117	19	sequestration	sequestration	NN
cord-281188-0cql96hu	117	20	of	of	IN
cord-281188-0cql96hu	117	21	the	the	DT
cord-281188-0cql96hu	117	22	major	major	JJ
cord-281188-0cql96hu	117	23	autolysin	autolysin	NNP
cord-281188-0cql96hu	117	24	LytA	LytA	NNP
cord-281188-0cql96hu	117	25	by	by	IN
cord-281188-0cql96hu	117	26	membrane	membrane	NN
cord-281188-0cql96hu	117	27	-	-	HYPH
cord-281188-0cql96hu	117	28	bound	bind	VBN
cord-281188-0cql96hu	117	29	lipoteichoic	lipoteichoic	NNP
cord-281188-0cql96hu	117	30	acids	acid	NNS
cord-281188-0cql96hu	117	31	.	.	.
cord-281188-0cql96hu	118	1	In	in	IN
cord-281188-0cql96hu	118	2	mutant	mutant	JJ
cord-281188-0cql96hu	118	3	Bacillus	bacillus	NN
cord-281188-0cql96hu	118	4	subtilis	subtili	NNS
cord-281188-0cql96hu	118	5	strains	strain	NNS
cord-281188-0cql96hu	118	6	,	,	,
cord-281188-0cql96hu	118	7	in	in	IN
cord-281188-0cql96hu	118	8	which	which	WDT
cord-281188-0cql96hu	118	9	teichoic	teichoic	NNP
cord-281188-0cql96hu	118	10	acid	acid	NNP
cord-281188-0cql96hu	118	11	-	-	HYPH
cord-281188-0cql96hu	118	12	autolysin	autolysin	NNP
cord-281188-0cql96hu	118	13	binding	binding	NN
cord-281188-0cql96hu	118	14	is	be	VBZ
cord-281188-0cql96hu	118	15	altered	alter	VBN
cord-281188-0cql96hu	118	16	by	by	IN
cord-281188-0cql96hu	118	17	reduction	reduction	NN
cord-281188-0cql96hu	118	18	of	of	IN
cord-281188-0cql96hu	118	19	positively	positively	RB
cord-281188-0cql96hu	118	20	charged	charge	VBN
cord-281188-0cql96hu	118	21	d	d	JJ
cord-281188-0cql96hu	118	22	-	-	HYPH
cord-281188-0cql96hu	118	23	alanine	alanine	JJ
cord-281188-0cql96hu	118	24	esters	ester	NNS
cord-281188-0cql96hu	118	25	in	in	IN
cord-281188-0cql96hu	118	26	teichoic	teichoic	NNP
cord-281188-0cql96hu	118	27	acids	acid	NNS
cord-281188-0cql96hu	118	28	,	,	,
cord-281188-0cql96hu	118	29	autolysis	autolysis	NN
cord-281188-0cql96hu	118	30	is	be	VBZ
cord-281188-0cql96hu	118	31	increased	increase	VBN
cord-281188-0cql96hu	118	32	under	under	IN
cord-281188-0cql96hu	118	33	β	β	NN
cord-281188-0cql96hu	118	34	-	-	HYPH
cord-281188-0cql96hu	118	35	lactam	lactam	NN
cord-281188-0cql96hu	118	36	exposure	exposure	NN
cord-281188-0cql96hu	118	37	56	56	CD
cord-281188-0cql96hu	118	38	.	.	.
cord-281188-0cql96hu	119	1	In	in	IN
cord-281188-0cql96hu	119	2	S.	S.	NNP
cord-281188-0cql96hu	119	3	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	119	4	,	,	,
cord-281188-0cql96hu	119	5	the	the	DT
cord-281188-0cql96hu	119	6	availability	availability	NN
cord-281188-0cql96hu	119	7	of	of	IN
cord-281188-0cql96hu	119	8	precursors	precursor	NNS
cord-281188-0cql96hu	119	9	and	and	CC
cord-281188-0cql96hu	119	10	products	product	NNS
cord-281188-0cql96hu	119	11	of	of	IN
cord-281188-0cql96hu	119	12	teichoic	teichoic	NNP
cord-281188-0cql96hu	119	13	acids	acid	NNS
cord-281188-0cql96hu	119	14	regulates	regulate	VBZ
cord-281188-0cql96hu	119	15	the	the	DT
cord-281188-0cql96hu	119	16	protease	protease	NN
cord-281188-0cql96hu	119	17	FtsH	FtsH	NNP
cord-281188-0cql96hu	119	18	,	,	,
cord-281188-0cql96hu	119	19	influencing	influence	VBG
cord-281188-0cql96hu	119	20	the	the	DT
cord-281188-0cql96hu	119	21	balance	balance	NN
cord-281188-0cql96hu	119	22	between	between	IN
cord-281188-0cql96hu	119	23	lipid	lipid	NN
cord-281188-0cql96hu	119	24	membrane	membrane	NN
cord-281188-0cql96hu	119	25	-	-	HYPH
cord-281188-0cql96hu	119	26	associated	associate	VBN
cord-281188-0cql96hu	119	27	teichoic	teichoic	NN
cord-281188-0cql96hu	119	28	acids	acid	NNS
cord-281188-0cql96hu	119	29	and	and	CC
cord-281188-0cql96hu	119	30	cell	cell	NN
cord-281188-0cql96hu	119	31	wall	wall	NN
cord-281188-0cql96hu	119	32	(	(	-LRB-
cord-281188-0cql96hu	119	33	peptidoglycan)-associated	peptidoglycan)-associated	JJ
cord-281188-0cql96hu	119	34	teichoic	teichoic	JJ
cord-281188-0cql96hu	119	35	acids	acid	NNS
cord-281188-0cql96hu	119	36	.	.	.
cord-281188-0cql96hu	120	1	Teichoic	teichoic	JJ
cord-281188-0cql96hu	120	2	acid	acid	NN
cord-281188-0cql96hu	120	3	polymers	polymer	NNS
cord-281188-0cql96hu	120	4	can	can	MD
cord-281188-0cql96hu	120	5	account	account	VB
cord-281188-0cql96hu	120	6	for	for	IN
cord-281188-0cql96hu	120	7	more	more	JJR
cord-281188-0cql96hu	120	8	than	than	IN
cord-281188-0cql96hu	120	9	60	60	CD
cord-281188-0cql96hu	120	10	%	%	NN
cord-281188-0cql96hu	120	11	of	of	IN
cord-281188-0cql96hu	120	12	the	the	DT
cord-281188-0cql96hu	120	13	mass	mass	NN
cord-281188-0cql96hu	120	14	of	of	IN
cord-281188-0cql96hu	120	15	the	the	DT
cord-281188-0cql96hu	120	16	Gram	Gram	NNP
cord-281188-0cql96hu	120	17	-	-	HYPH
cord-281188-0cql96hu	120	18	positive	positive	JJ
cord-281188-0cql96hu	120	19	cell	cell	NN
cord-281188-0cql96hu	120	20	wall	wall	NN
cord-281188-0cql96hu	120	21	57	57	CD
cord-281188-0cql96hu	120	22	.	.	.
cord-281188-0cql96hu	121	1	Under	under	IN
cord-281188-0cql96hu	121	2	penicillin	penicillin	NN
cord-281188-0cql96hu	121	3	(	(	-LRB-
cord-281188-0cql96hu	121	4	a	a	DT
cord-281188-0cql96hu	121	5	β	β	NN
cord-281188-0cql96hu	121	6	-	-	HYPH
cord-281188-0cql96hu	121	7	lactam	lactam	NNP
cord-281188-0cql96hu	121	8	)	)	-RRB-
cord-281188-0cql96hu	121	9	exposure	exposure	NN
cord-281188-0cql96hu	121	10	(	(	-LRB-
cord-281188-0cql96hu	121	11	or	or	CC
cord-281188-0cql96hu	121	12	prolonged	prolong	VBN
cord-281188-0cql96hu	121	13	stationary	stationary	JJ
cord-281188-0cql96hu	121	14	phase	phase	NN
cord-281188-0cql96hu	121	15	)	)	-RRB-
cord-281188-0cql96hu	121	16	,	,	,
cord-281188-0cql96hu	121	17	FtsH	FtsH	NNP
cord-281188-0cql96hu	121	18	degrades	degrade	VBZ
cord-281188-0cql96hu	121	19	the	the	DT
cord-281188-0cql96hu	121	20	lipid	lipid	NN
cord-281188-0cql96hu	121	21	membrane	membrane	NN
cord-281188-0cql96hu	121	22	-	-	HYPH
cord-281188-0cql96hu	121	23	associated	associate	VBN
cord-281188-0cql96hu	121	24	teichoic	teichoic	NN
cord-281188-0cql96hu	121	25	acid	acid	NN
cord-281188-0cql96hu	121	26	synthase	synthase	NN
cord-281188-0cql96hu	121	27	TacL	TacL	NNP
cord-281188-0cql96hu	121	28	,	,	,
cord-281188-0cql96hu	121	29	leading	lead	VBG
cord-281188-0cql96hu	121	30	to	to	IN
cord-281188-0cql96hu	121	31	a	a	DT
cord-281188-0cql96hu	121	32	short	short	JJ
cord-281188-0cql96hu	121	33	circuit	circuit	NN
cord-281188-0cql96hu	121	34	in	in	IN
cord-281188-0cql96hu	121	35	the	the	DT
cord-281188-0cql96hu	121	36	normal	normal	JJ
cord-281188-0cql96hu	121	37	teichoic	teichoic	NN
cord-281188-0cql96hu	121	38	acid	acid	NN
cord-281188-0cql96hu	121	39	balancing	balancing	NN
cord-281188-0cql96hu	121	40	mechanism	mechanism	NN
cord-281188-0cql96hu	121	41	,	,	,
cord-281188-0cql96hu	121	42	favouring	favour	VBG
cord-281188-0cql96hu	121	43	synthesis	synthesis	NN
cord-281188-0cql96hu	121	44	of	of	IN
cord-281188-0cql96hu	121	45	cell	cell	NN
cord-281188-0cql96hu	121	46	wall	wall	NN
cord-281188-0cql96hu	121	47	-	-	HYPH
cord-281188-0cql96hu	121	48	associated	associate	VBN
cord-281188-0cql96hu	121	49	teichoic	teichoic	NNP
cord-281188-0cql96hu	121	50	acids	acid	NNS
cord-281188-0cql96hu	121	51	,	,	,
cord-281188-0cql96hu	121	52	which	which	WDT
cord-281188-0cql96hu	121	53	stimulates	stimulate	VBZ
cord-281188-0cql96hu	121	54	cell	cell	NN
cord-281188-0cql96hu	121	55	wall	wall	NN
cord-281188-0cql96hu	121	56	-	-	HYPH
cord-281188-0cql96hu	121	57	destructive	destructive	JJ
cord-281188-0cql96hu	121	58	LytA	LytA	NNP
cord-281188-0cql96hu	121	59	activity	activity	NN
cord-281188-0cql96hu	121	60	,	,	,
cord-281188-0cql96hu	121	61	ending	end	VBG
cord-281188-0cql96hu	121	62	in	in	IN
cord-281188-0cql96hu	121	63	cell	cell	NN
cord-281188-0cql96hu	121	64	lysis	lysis	NN
cord-281188-0cql96hu	121	65	58	58	CD
cord-281188-0cql96hu	121	66	.	.	.
cord-281188-0cql96hu	122	1	In	in	IN
cord-281188-0cql96hu	122	2	Gram	gram	NN
cord-281188-0cql96hu	122	3	-	-	HYPH
cord-281188-0cql96hu	122	4	negative	negative	JJ
cord-281188-0cql96hu	122	5	bacteria	bacteria	NNS
cord-281188-0cql96hu	122	6	,	,	,
cord-281188-0cql96hu	122	7	LPS	lp	NNS
cord-281188-0cql96hu	122	8	in	in	IN
cord-281188-0cql96hu	122	9	the	the	DT
cord-281188-0cql96hu	122	10	outer	outer	JJ
cord-281188-0cql96hu	122	11	membrane	membrane	NN
cord-281188-0cql96hu	122	12	is	be	VBZ
cord-281188-0cql96hu	122	13	the	the	DT
cord-281188-0cql96hu	122	14	functional	functional	JJ
cord-281188-0cql96hu	122	15	equivalent	equivalent	NN
cord-281188-0cql96hu	122	16	of	of	IN
cord-281188-0cql96hu	122	17	the	the	DT
cord-281188-0cql96hu	122	18	lipid	lipid	NN
cord-281188-0cql96hu	122	19	membrane	membrane	NN
cord-281188-0cql96hu	122	20	-	-	HYPH
cord-281188-0cql96hu	122	21	associated	associate	VBN
cord-281188-0cql96hu	122	22	teichoic	teichoic	NN
cord-281188-0cql96hu	122	23	acids	acid	NNS
cord-281188-0cql96hu	122	24	in	in	IN
cord-281188-0cql96hu	122	25	Gram	gram	NN
cord-281188-0cql96hu	122	26	-	-	HYPH
cord-281188-0cql96hu	122	27	positive	positive	JJ
cord-281188-0cql96hu	122	28	bacteria	bacteria	NNS
cord-281188-0cql96hu	122	29	.	.	.
cord-281188-0cql96hu	123	1	In	in	IN
cord-281188-0cql96hu	123	2	this	this	DT
cord-281188-0cql96hu	123	3	case	case	NN
cord-281188-0cql96hu	123	4	,	,	,
cord-281188-0cql96hu	123	5	the	the	DT
cord-281188-0cql96hu	123	6	protease	protease	NN
cord-281188-0cql96hu	123	7	FtsH	FtsH	NNS
cord-281188-0cql96hu	123	8	alter	alter	VB
cord-281188-0cql96hu	123	9	the	the	DT
cord-281188-0cql96hu	123	10	turnover	turnover	NN
cord-281188-0cql96hu	123	11	of	of	IN
cord-281188-0cql96hu	123	12	LpxC	LpxC	NNP
cord-281188-0cql96hu	123	13	,	,	,
cord-281188-0cql96hu	123	14	an	an	DT
cord-281188-0cql96hu	123	15	essential	essential	JJ
cord-281188-0cql96hu	123	16	enzyme	enzyme	NN
cord-281188-0cql96hu	123	17	for	for	IN
cord-281188-0cql96hu	123	18	virtually	virtually	RB
cord-281188-0cql96hu	123	19	all	all	DT
cord-281188-0cql96hu	123	20	Gram	gram	NN
cord-281188-0cql96hu	123	21	-	-	HYPH
cord-281188-0cql96hu	123	22	negative	negative	JJ
cord-281188-0cql96hu	123	23	bacteria	bacteria	NNS
cord-281188-0cql96hu	123	24	,	,	,
cord-281188-0cql96hu	123	25	which	which	WDT
cord-281188-0cql96hu	123	26	is	be	VBZ
cord-281188-0cql96hu	123	27	involved	involve	VBN
cord-281188-0cql96hu	123	28	in	in	IN
cord-281188-0cql96hu	123	29	the	the	DT
cord-281188-0cql96hu	123	30	first	first	JJ
cord-281188-0cql96hu	123	31	step	step	NN
cord-281188-0cql96hu	123	32	of	of	IN
cord-281188-0cql96hu	123	33	LPS	LPS	NNP
cord-281188-0cql96hu	123	34	biosynthesis	biosynthesis	NN
cord-281188-0cql96hu	123	35	,	,	,
cord-281188-0cql96hu	123	36	formation	formation	NN
cord-281188-0cql96hu	123	37	of	of	IN
cord-281188-0cql96hu	123	38	lipid	lipid	NN
cord-281188-0cql96hu	123	39	A	a	DT
cord-281188-0cql96hu	123	40	59	59	CD
cord-281188-0cql96hu	123	41	.	.	.
cord-281188-0cql96hu	124	1	Similarly	similarly	RB
cord-281188-0cql96hu	124	2	to	to	IN
cord-281188-0cql96hu	124	3	FtsH	FtsH	NNP
cord-281188-0cql96hu	124	4	in	in	IN
cord-281188-0cql96hu	124	5	S.	S.	NNP
cord-281188-0cql96hu	124	6	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	124	7	,	,	,
cord-281188-0cql96hu	124	8	FtsH	FtsH	NNP
cord-281188-0cql96hu	124	9	in	in	IN
cord-281188-0cql96hu	124	10	Gram	gram	NN
cord-281188-0cql96hu	124	11	-	-	HYPH
cord-281188-0cql96hu	124	12	negative	negative	JJ
cord-281188-0cql96hu	124	13	bacteria	bacteria	NNS
cord-281188-0cql96hu	124	14	is	be	VBZ
cord-281188-0cql96hu	124	15	regulated	regulate	VBN
cord-281188-0cql96hu	124	16	by	by	IN
cord-281188-0cql96hu	124	17	the	the	DT
cord-281188-0cql96hu	124	18	availability	availability	NN
cord-281188-0cql96hu	124	19	of	of	IN
cord-281188-0cql96hu	124	20	precursors	precursor	NNS
cord-281188-0cql96hu	124	21	and	and	CC
cord-281188-0cql96hu	124	22	products	product	NNS
cord-281188-0cql96hu	124	23	of	of	IN
cord-281188-0cql96hu	124	24	the	the	DT
cord-281188-0cql96hu	124	25	LPS	LPS	NNP
cord-281188-0cql96hu	124	26	synthetic	synthetic	NN
cord-281188-0cql96hu	124	27	pathway	pathway	NN
cord-281188-0cql96hu	124	28	,	,	,
cord-281188-0cql96hu	124	29	including	include	VBG
cord-281188-0cql96hu	124	30	acyl	acyl	NN
cord-281188-0cql96hu	124	31	-	-	HYPH
cord-281188-0cql96hu	124	32	acyl	acyl	NN
cord-281188-0cql96hu	124	33	carrier	carrier	NN
cord-281188-0cql96hu	124	34	protein	protein	NN
cord-281188-0cql96hu	124	35	(	(	-LRB-
cord-281188-0cql96hu	124	36	acyl	acyl	NNP
cord-281188-0cql96hu	124	37	-	-	HYPH
cord-281188-0cql96hu	124	38	ACP	ACP	NNP
cord-281188-0cql96hu	124	39	)	)	-RRB-
cord-281188-0cql96hu	124	40	precursors	precursor	NNS
cord-281188-0cql96hu	124	41	.	.	.
cord-281188-0cql96hu	125	1	Acyl	Acyl	NNP
cord-281188-0cql96hu	125	2	-	-	HYPH
cord-281188-0cql96hu	125	3	ACP	ACP	NNP
cord-281188-0cql96hu	125	4	accumulation	accumulation	NN
cord-281188-0cql96hu	125	5	probably	probably	RB
cord-281188-0cql96hu	125	6	correlates	correlate	VBZ
cord-281188-0cql96hu	125	7	with	with	IN
cord-281188-0cql96hu	125	8	a	a	DT
cord-281188-0cql96hu	125	9	decrease	decrease	NN
cord-281188-0cql96hu	125	10	in	in	IN
cord-281188-0cql96hu	125	11	fatty	fatty	JJ
cord-281188-0cql96hu	125	12	acid	acid	NN
cord-281188-0cql96hu	125	13	synthesis	synthesis	NN
cord-281188-0cql96hu	125	14	in	in	IN
cord-281188-0cql96hu	125	15	S.	S.	NNP
cord-281188-0cql96hu	125	16	aureus	aureus	NN
cord-281188-0cql96hu	125	17	and	and	CC
cord-281188-0cql96hu	125	18	also	also	RB
cord-281188-0cql96hu	125	19	in	in	IN
cord-281188-0cql96hu	125	20	E.	E.	NNP
cord-281188-0cql96hu	125	21	coli	coli	NNS
cord-281188-0cql96hu	125	22	,	,	,
cord-281188-0cql96hu	125	23	as	as	IN
cord-281188-0cql96hu	125	24	in	in	IN
cord-281188-0cql96hu	125	25	vivo	vivo	NNP
cord-281188-0cql96hu	125	26	data	datum	NNS
cord-281188-0cql96hu	125	27	are	be	VBP
cord-281188-0cql96hu	125	28	consistent	consistent	JJ
cord-281188-0cql96hu	125	29	with	with	IN
cord-281188-0cql96hu	125	30	acyl	acyl	NNP
cord-281188-0cql96hu	125	31	-	-	HYPH
cord-281188-0cql96hu	125	32	ACP	ACP	NNP
cord-281188-0cql96hu	125	33	targeting	target	VBG
cord-281188-0cql96hu	125	34	the	the	DT
cord-281188-0cql96hu	125	35	same	same	JJ
cord-281188-0cql96hu	125	36	two	two	CD
cord-281188-0cql96hu	125	37	proteins	protein	NNS
cord-281188-0cql96hu	125	38	in	in	IN
cord-281188-0cql96hu	125	39	both	both	DT
cord-281188-0cql96hu	125	40	species	specie	NNS
cord-281188-0cql96hu	125	41	59	59	CD
cord-281188-0cql96hu	125	42	,	,	,
cord-281188-0cql96hu	125	43	60	60	CD
cord-281188-0cql96hu	125	44	.	.	.
cord-281188-0cql96hu	126	1	In	in	IN
cord-281188-0cql96hu	126	2	E.	E.	NNP
cord-281188-0cql96hu	126	3	coli	coli	NNS
cord-281188-0cql96hu	126	4	,	,	,
cord-281188-0cql96hu	126	5	the	the	DT
cord-281188-0cql96hu	126	6	outer	outer	JJ
cord-281188-0cql96hu	126	7	membrane	membrane	NN
cord-281188-0cql96hu	126	8	LPS	lp	NNS
cord-281188-0cql96hu	126	9	and	and	CC
cord-281188-0cql96hu	126	10	the	the	DT
cord-281188-0cql96hu	126	11	cell	cell	NN
cord-281188-0cql96hu	126	12	membrane	membrane	NN
cord-281188-0cql96hu	126	13	phospholipid	phospholipid	NN
cord-281188-0cql96hu	126	14	synthesis	synthesis	NN
cord-281188-0cql96hu	126	15	pathways	pathway	NNS
cord-281188-0cql96hu	126	16	compete	compete	VBP
cord-281188-0cql96hu	126	17	for	for	IN
cord-281188-0cql96hu	126	18	fatty	fatty	JJ
cord-281188-0cql96hu	126	19	acids	acid	NNS
cord-281188-0cql96hu	126	20	61	61	CD
cord-281188-0cql96hu	126	21	,	,	,
cord-281188-0cql96hu	126	22	leading	lead	VBG
cord-281188-0cql96hu	126	23	to	to	IN
cord-281188-0cql96hu	126	24	a	a	DT
cord-281188-0cql96hu	126	25	destabilization	destabilization	NN
cord-281188-0cql96hu	126	26	of	of	IN
cord-281188-0cql96hu	126	27	the	the	DT
cord-281188-0cql96hu	126	28	outer	outer	JJ
cord-281188-0cql96hu	126	29	membrane	membrane	NN
cord-281188-0cql96hu	126	30	(	(	-LRB-
cord-281188-0cql96hu	126	31	less	less	JJR
cord-281188-0cql96hu	126	32	LPS	LPS	NNP
cord-281188-0cql96hu	126	33	)	)	-RRB-
cord-281188-0cql96hu	126	34	.	.	.
cord-281188-0cql96hu	127	1	It	-PRON-	PRP
cord-281188-0cql96hu	127	2	should	should	MD
cord-281188-0cql96hu	127	3	be	be	VB
cord-281188-0cql96hu	127	4	remembered	remember	VBN
cord-281188-0cql96hu	127	5	that	that	IN
cord-281188-0cql96hu	127	6	the	the	DT
cord-281188-0cql96hu	127	7	maintenance	maintenance	NN
cord-281188-0cql96hu	127	8	of	of	IN
cord-281188-0cql96hu	127	9	the	the	DT
cord-281188-0cql96hu	127	10	outer	outer	JJ
cord-281188-0cql96hu	127	11	membrane	membrane	NN
cord-281188-0cql96hu	127	12	integrity	integrity	NN
cord-281188-0cql96hu	127	13	in	in	IN
cord-281188-0cql96hu	127	14	Gram	gram	NN
cord-281188-0cql96hu	127	15	-	-	HYPH
cord-281188-0cql96hu	127	16	negative	negative	JJ
cord-281188-0cql96hu	127	17	bacteria	bacteria	NNS
cord-281188-0cql96hu	127	18	is	be	VBZ
cord-281188-0cql96hu	127	19	probably	probably	RB
cord-281188-0cql96hu	127	20	as	as	RB
cord-281188-0cql96hu	127	21	important	important	JJ
cord-281188-0cql96hu	127	22	as	as	IN
cord-281188-0cql96hu	127	23	the	the	DT
cord-281188-0cql96hu	127	24	maintenance	maintenance	NN
cord-281188-0cql96hu	127	25	of	of	IN
cord-281188-0cql96hu	127	26	the	the	DT
cord-281188-0cql96hu	127	27	integrity	integrity	NN
cord-281188-0cql96hu	127	28	of	of	IN
cord-281188-0cql96hu	127	29	the	the	DT
cord-281188-0cql96hu	127	30	cell	cell	NN
cord-281188-0cql96hu	127	31	wall	wall	NN
cord-281188-0cql96hu	127	32	,	,	,
cord-281188-0cql96hu	127	33	and	and	CC
cord-281188-0cql96hu	127	34	its	-PRON-	PRP$
cord-281188-0cql96hu	127	35	failure	failure	NN
cord-281188-0cql96hu	127	36	produces	produce	VBZ
cord-281188-0cql96hu	127	37	blebbing	blebbe	VBG
cord-281188-0cql96hu	127	38	and	and	CC
cord-281188-0cql96hu	127	39	killing	kill	VBG
cord-281188-0cql96hu	127	40	62	62	CD
cord-281188-0cql96hu	127	41	.	.	.
cord-281188-0cql96hu	128	1	In	in	IN
cord-281188-0cql96hu	128	2	summary	summary	NN
cord-281188-0cql96hu	128	3	,	,	,
cord-281188-0cql96hu	128	4	the	the	DT
cord-281188-0cql96hu	128	5	viability	viability	NN
cord-281188-0cql96hu	128	6	of	of	IN
cord-281188-0cql96hu	128	7	the	the	DT
cord-281188-0cql96hu	128	8	cell	cell	NN
cord-281188-0cql96hu	128	9	depends	depend	VBZ
cord-281188-0cql96hu	128	10	on	on	IN
cord-281188-0cql96hu	128	11	a	a	DT
cord-281188-0cql96hu	128	12	balanced	balanced	JJ
cord-281188-0cql96hu	128	13	synthesis	synthesis	NN
cord-281188-0cql96hu	128	14	of	of	IN
cord-281188-0cql96hu	128	15	membrane	membrane	NN
cord-281188-0cql96hu	128	16	phospholipids	phospholipid	NNS
cord-281188-0cql96hu	128	17	,	,	,
cord-281188-0cql96hu	128	18	fatty	fatty	JJ
cord-281188-0cql96hu	128	19	acids	acid	NNS
cord-281188-0cql96hu	128	20	and	and	CC
cord-281188-0cql96hu	128	21	cell	cell	NN
cord-281188-0cql96hu	128	22	wall	wall	NN
cord-281188-0cql96hu	128	23	constituents	constituent	NNS
cord-281188-0cql96hu	128	24	63	63	CD
cord-281188-0cql96hu	128	25	,	,	,
cord-281188-0cql96hu	128	26	and	and	CC
cord-281188-0cql96hu	128	27	this	this	DT
cord-281188-0cql96hu	128	28	coordination	coordination	NN
cord-281188-0cql96hu	128	29	is	be	VBZ
cord-281188-0cql96hu	128	30	altered	alter	VBN
cord-281188-0cql96hu	128	31	by	by	IN
cord-281188-0cql96hu	128	32	β	β	NN
cord-281188-0cql96hu	128	33	-	-	HYPH
cord-281188-0cql96hu	128	34	lactam	lactam	NN
cord-281188-0cql96hu	128	35	exposure	exposure	NN
cord-281188-0cql96hu	128	36	.	.	.
cord-281188-0cql96hu	129	1	However	however	RB
cord-281188-0cql96hu	129	2	,	,	,
cord-281188-0cql96hu	129	3	autolysis	autolysis	NN
cord-281188-0cql96hu	129	4	can	can	MD
cord-281188-0cql96hu	129	5	also	also	RB
cord-281188-0cql96hu	129	6	occur	occur	VB
cord-281188-0cql96hu	129	7	without	without	IN
cord-281188-0cql96hu	129	8	specific	specific	JJ
cord-281188-0cql96hu	129	9	induction	induction	NN
cord-281188-0cql96hu	129	10	of	of	IN
cord-281188-0cql96hu	129	11	autolysins	autolysin	NNS
cord-281188-0cql96hu	129	12	but	but	CC
cord-281188-0cql96hu	129	13	rather	rather	RB
cord-281188-0cql96hu	129	14	as	as	IN
cord-281188-0cql96hu	129	15	a	a	DT
cord-281188-0cql96hu	129	16	consequence	consequence	NN
cord-281188-0cql96hu	129	17	of	of	IN
cord-281188-0cql96hu	129	18	disbalance	disbalance	NN
cord-281188-0cql96hu	129	19	(	(	-LRB-
cord-281188-0cql96hu	129	20	uncoupling	uncouple	VBG
cord-281188-0cql96hu	129	21	)	)	-RRB-
cord-281188-0cql96hu	129	22	between	between	IN
cord-281188-0cql96hu	129	23	cell	cell	NN
cord-281188-0cql96hu	129	24	wall	wall	NN
cord-281188-0cql96hu	129	25	synthesis	synthesis	NN
cord-281188-0cql96hu	129	26	and	and	CC
cord-281188-0cql96hu	129	27	degradation	degradation	NN
cord-281188-0cql96hu	129	28	,	,	,
cord-281188-0cql96hu	129	29	owing	owe	VBG
cord-281188-0cql96hu	129	30	to	to	IN
cord-281188-0cql96hu	129	31	lack	lack	NN
cord-281188-0cql96hu	129	32	of	of	IN
cord-281188-0cql96hu	129	33	control	control	NN
cord-281188-0cql96hu	129	34	of	of	IN
cord-281188-0cql96hu	129	35	peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	129	36	hydrolase	hydrolase	NNP
cord-281188-0cql96hu	129	37	turnover	turnover	NN
cord-281188-0cql96hu	129	38	,	,	,
cord-281188-0cql96hu	129	39	typically	typically	RB
cord-281188-0cql96hu	129	40	involving	involve	VBG
cord-281188-0cql96hu	129	41	low	low	JJ
cord-281188-0cql96hu	129	42	molecular	molecular	JJ
cord-281188-0cql96hu	129	43	weight	weight	NN
cord-281188-0cql96hu	129	44	penicillin	penicillin	NN
cord-281188-0cql96hu	129	45	-	-	HYPH
cord-281188-0cql96hu	129	46	binding	bind	VBG
cord-281188-0cql96hu	129	47	proteins	protein	NNS
cord-281188-0cql96hu	129	48	that	that	WDT
cord-281188-0cql96hu	129	49	function	function	VBP
cord-281188-0cql96hu	129	50	as	as	IN
cord-281188-0cql96hu	129	51	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	129	52	-	-	HYPH
cord-281188-0cql96hu	129	53	binding	bind	VBG
cord-281188-0cql96hu	129	54	peptidases	peptidase	NNS
cord-281188-0cql96hu	129	55	in	in	IN
cord-281188-0cql96hu	129	56	E.	E.	NNP
cord-281188-0cql96hu	129	57	coli	coli	NNS
cord-281188-0cql96hu	129	58	[	[	-LRB-
cord-281188-0cql96hu	129	59	64	64	CD
cord-281188-0cql96hu	129	60	]	]	-RRB-
cord-281188-0cql96hu	130	1	[	[	-LRB-
cord-281188-0cql96hu	130	2	65	65	CD
cord-281188-0cql96hu	130	3	]	]	-RRB-
cord-281188-0cql96hu	130	4	[	[	-LRB-
cord-281188-0cql96hu	130	5	66	66	CD
cord-281188-0cql96hu	130	6	]	]	-RRB-
cord-281188-0cql96hu	130	7	.	.	.
cord-281188-0cql96hu	131	1	How	how	WRB
cord-281188-0cql96hu	131	2	endogenous	endogenous	JJ
cord-281188-0cql96hu	131	3	mechanisms	mechanism	NNS
cord-281188-0cql96hu	131	4	can	can	MD
cord-281188-0cql96hu	131	5	degrade	degrade	VB
cord-281188-0cql96hu	131	6	the	the	DT
cord-281188-0cql96hu	131	7	cytoplasmic	cytoplasmic	JJ
cord-281188-0cql96hu	131	8	membrane	membrane	NN
cord-281188-0cql96hu	131	9	is	be	VBZ
cord-281188-0cql96hu	131	10	less	less	RBR
cord-281188-0cql96hu	131	11	clear	clear	JJ
cord-281188-0cql96hu	131	12	.	.	.
cord-281188-0cql96hu	132	1	Aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	132	2	interact	interact	VBP
cord-281188-0cql96hu	132	3	with	with	IN
cord-281188-0cql96hu	132	4	ribosomes	ribosome	NNS
cord-281188-0cql96hu	132	5	,	,	,
cord-281188-0cql96hu	132	6	leading	lead	VBG
cord-281188-0cql96hu	132	7	to	to	IN
cord-281188-0cql96hu	132	8	production	production	NN
cord-281188-0cql96hu	132	9	of	of	IN
cord-281188-0cql96hu	132	10	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	132	11	proteins	protein	NNS
cord-281188-0cql96hu	132	12	.	.	.
cord-281188-0cql96hu	133	1	These	these	DT
cord-281188-0cql96hu	133	2	proteins	protein	NNS
cord-281188-0cql96hu	133	3	are	be	VBP
cord-281188-0cql96hu	133	4	misassembled	misassemble	VBN
cord-281188-0cql96hu	133	5	in	in	IN
cord-281188-0cql96hu	133	6	the	the	DT
cord-281188-0cql96hu	133	7	membrane	membrane	NN
cord-281188-0cql96hu	133	8	and	and	CC
cord-281188-0cql96hu	133	9	are	be	VBP
cord-281188-0cql96hu	133	10	rapidly	rapidly	RB
cord-281188-0cql96hu	133	11	degraded	degrade	VBN
cord-281188-0cql96hu	133	12	,	,	,
cord-281188-0cql96hu	133	13	which	which	WDT
cord-281188-0cql96hu	133	14	contributes	contribute	VBZ
cord-281188-0cql96hu	133	15	to	to	IN
cord-281188-0cql96hu	133	16	bacterial	bacterial	JJ
cord-281188-0cql96hu	133	17	killing	kill	VBG
cord-281188-0cql96hu	133	18	67	67	CD
cord-281188-0cql96hu	133	19	,	,	,
cord-281188-0cql96hu	133	20	68	68	CD
cord-281188-0cql96hu	133	21	.	.	.
cord-281188-0cql96hu	134	1	Degradation	degradation	NN
cord-281188-0cql96hu	134	2	of	of	IN
cord-281188-0cql96hu	134	3	misassembled	misassembled	JJ
cord-281188-0cql96hu	134	4	membrane	membrane	NN
cord-281188-0cql96hu	134	5	proteins	protein	NNS
cord-281188-0cql96hu	134	6	is	be	VBZ
cord-281188-0cql96hu	134	7	the	the	DT
cord-281188-0cql96hu	134	8	result	result	NN
cord-281188-0cql96hu	134	9	of	of	IN
cord-281188-0cql96hu	134	10	a	a	DT
cord-281188-0cql96hu	134	11	proteolytic	proteolytic	JJ
cord-281188-0cql96hu	134	12	'	'	''
cord-281188-0cql96hu	134	13	quality	quality	NN
cord-281188-0cql96hu	134	14	control	control	NN
cord-281188-0cql96hu	134	15	'	'	''
cord-281188-0cql96hu	134	16	system	system	NN
cord-281188-0cql96hu	134	17	,	,	,
cord-281188-0cql96hu	134	18	which	which	WDT
cord-281188-0cql96hu	134	19	includes	include	VBZ
cord-281188-0cql96hu	134	20	the	the	DT
cord-281188-0cql96hu	134	21	membrane	membrane	NN
cord-281188-0cql96hu	134	22	-	-	HYPH
cord-281188-0cql96hu	134	23	integrated	integrate	VBN
cord-281188-0cql96hu	134	24	protease	protease	NN
cord-281188-0cql96hu	134	25	FtsH	FtsH	NNP
cord-281188-0cql96hu	134	26	69	69	CD
cord-281188-0cql96hu	134	27	.	.	.
cord-281188-0cql96hu	135	1	Other	other	JJ
cord-281188-0cql96hu	135	2	ATP	ATP	NNP
cord-281188-0cql96hu	135	3	-	-	HYPH
cord-281188-0cql96hu	135	4	dependent	dependent	JJ
cord-281188-0cql96hu	135	5	AAA+	AAA+	NNP
cord-281188-0cql96hu	135	6	proteases	protease	NNS
cord-281188-0cql96hu	135	7	,	,	,
cord-281188-0cql96hu	135	8	including	include	VBG
cord-281188-0cql96hu	135	9	ClpP	ClpP	NNP
cord-281188-0cql96hu	135	10	and	and	CC
cord-281188-0cql96hu	135	11	the	the	DT
cord-281188-0cql96hu	135	12	Lon	Lon	NNP
cord-281188-0cql96hu	135	13	proteases	protease	NNS
cord-281188-0cql96hu	135	14	,	,	,
cord-281188-0cql96hu	135	15	which	which	WDT
cord-281188-0cql96hu	135	16	are	be	VBP
cord-281188-0cql96hu	135	17	present	present	JJ
cord-281188-0cql96hu	135	18	in	in	IN
cord-281188-0cql96hu	135	19	many	many	JJ
cord-281188-0cql96hu	135	20	bacterial	bacterial	JJ
cord-281188-0cql96hu	135	21	species	specie	NNS
cord-281188-0cql96hu	135	22	,	,	,
cord-281188-0cql96hu	135	23	are	be	VBP
cord-281188-0cql96hu	135	24	also	also	RB
cord-281188-0cql96hu	135	25	involved	involve	VBN
cord-281188-0cql96hu	135	26	in	in	IN
cord-281188-0cql96hu	135	27	the	the	DT
cord-281188-0cql96hu	135	28	proteolysis	proteolysis	NN
cord-281188-0cql96hu	135	29	of	of	IN
cord-281188-0cql96hu	135	30	defective	defective	JJ
cord-281188-0cql96hu	135	31	and	and	CC
cord-281188-0cql96hu	135	32	misfolded	misfolded	JJ
cord-281188-0cql96hu	135	33	proteins	protein	NNS
cord-281188-0cql96hu	135	34	.	.	.
cord-281188-0cql96hu	136	1	As	as	IN
cord-281188-0cql96hu	136	2	in	in	IN
cord-281188-0cql96hu	136	3	the	the	DT
cord-281188-0cql96hu	136	4	case	case	NN
cord-281188-0cql96hu	136	5	for	for	IN
cord-281188-0cql96hu	136	6	the	the	DT
cord-281188-0cql96hu	136	7	cell	cell	NN
cord-281188-0cql96hu	136	8	wall	wall	NN
cord-281188-0cql96hu	136	9	,	,	,
cord-281188-0cql96hu	136	10	a	a	DT
cord-281188-0cql96hu	136	11	disbalance	disbalance	NN
cord-281188-0cql96hu	136	12	in	in	IN
cord-281188-0cql96hu	136	13	physiological	physiological	JJ
cord-281188-0cql96hu	136	14	proteolytic	proteolytic	JJ
cord-281188-0cql96hu	136	15	processes	process	NNS
cord-281188-0cql96hu	136	16	of	of	IN
cord-281188-0cql96hu	136	17	the	the	DT
cord-281188-0cql96hu	136	18	cell	cell	NN
cord-281188-0cql96hu	136	19	might	may	MD
cord-281188-0cql96hu	136	20	result	result	VB
cord-281188-0cql96hu	136	21	in	in	IN
cord-281188-0cql96hu	136	22	membrane	membrane	NN
cord-281188-0cql96hu	136	23	alteration	alteration	NN
cord-281188-0cql96hu	136	24	and	and	CC
cord-281188-0cql96hu	136	25	cell	cell	NN
cord-281188-0cql96hu	136	26	death	death	NN
cord-281188-0cql96hu	136	27	70	70	CD
cord-281188-0cql96hu	136	28	,	,	,
cord-281188-0cql96hu	136	29	71	71	CD
cord-281188-0cql96hu	136	30	.	.	.
cord-281188-0cql96hu	137	1	As	as	IN
cord-281188-0cql96hu	137	2	described	describe	VBN
cord-281188-0cql96hu	137	3	in	in	IN
cord-281188-0cql96hu	137	4	the	the	DT
cord-281188-0cql96hu	137	5	following	following	JJ
cord-281188-0cql96hu	137	6	section	section	NN
cord-281188-0cql96hu	137	7	,	,	,
cord-281188-0cql96hu	137	8	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	137	9	might	may	MD
cord-281188-0cql96hu	137	10	promote	promote	VB
cord-281188-0cql96hu	137	11	the	the	DT
cord-281188-0cql96hu	137	12	formation	formation	NN
cord-281188-0cql96hu	137	13	of	of	IN
cord-281188-0cql96hu	137	14	superoxides	superoxides	NNP
cord-281188-0cql96hu	137	15	,	,	,
cord-281188-0cql96hu	137	16	leading	lead	VBG
cord-281188-0cql96hu	137	17	to	to	IN
cord-281188-0cql96hu	137	18	the	the	DT
cord-281188-0cql96hu	137	19	oxydation	oxydation	NN
cord-281188-0cql96hu	137	20	of	of	IN
cord-281188-0cql96hu	137	21	cysteine	cysteine	NN
cord-281188-0cql96hu	137	22	and	and	CC
cord-281188-0cql96hu	137	23	methionine	methionine	NN
cord-281188-0cql96hu	137	24	,	,	,
cord-281188-0cql96hu	137	25	resulting	result	VBG
cord-281188-0cql96hu	137	26	in	in	IN
cord-281188-0cql96hu	137	27	protein	protein	NN
cord-281188-0cql96hu	137	28	damage	damage	NN
cord-281188-0cql96hu	137	29	.	.	.
cord-281188-0cql96hu	138	1	In	in	IN
cord-281188-0cql96hu	138	2	other	other	JJ
cord-281188-0cql96hu	138	3	words	word	NNS
cord-281188-0cql96hu	138	4	,	,	,
cord-281188-0cql96hu	138	5	we	-PRON-	PRP
cord-281188-0cql96hu	138	6	can	can	MD
cord-281188-0cql96hu	138	7	consider	consider	VB
cord-281188-0cql96hu	138	8	the	the	DT
cord-281188-0cql96hu	138	9	replacement	replacement	NN
cord-281188-0cql96hu	138	10	of	of	IN
cord-281188-0cql96hu	138	11	senescent	senescent	JJ
cord-281188-0cql96hu	138	12	or	or	CC
cord-281188-0cql96hu	138	13	damaged	damaged	JJ
cord-281188-0cql96hu	138	14	proteins	protein	NNS
cord-281188-0cql96hu	138	15	as	as	IN
cord-281188-0cql96hu	138	16	a	a	DT
cord-281188-0cql96hu	138	17	requirement	requirement	NN
cord-281188-0cql96hu	138	18	for	for	IN
cord-281188-0cql96hu	138	19	maintaining	maintain	VBG
cord-281188-0cql96hu	138	20	life	life	NN
cord-281188-0cql96hu	138	21	72	72	CD
cord-281188-0cql96hu	138	22	,	,	,
cord-281188-0cql96hu	138	23	73	73	CD
cord-281188-0cql96hu	138	24	.	.	.
cord-281188-0cql96hu	139	1	An	an	DT
cord-281188-0cql96hu	139	2	intriguing	intriguing	JJ
cord-281188-0cql96hu	139	3	possibility	possibility	NN
cord-281188-0cql96hu	139	4	that	that	IN
cord-281188-0cql96hu	139	5	we	-PRON-	PRP
cord-281188-0cql96hu	139	6	believe	believe	VBP
cord-281188-0cql96hu	139	7	is	be	VBZ
cord-281188-0cql96hu	139	8	worthy	worthy	JJ
cord-281188-0cql96hu	139	9	of	of	IN
cord-281188-0cql96hu	139	10	further	further	JJ
cord-281188-0cql96hu	139	11	exploration	exploration	NN
cord-281188-0cql96hu	139	12	is	be	VBZ
cord-281188-0cql96hu	139	13	a	a	DT
cord-281188-0cql96hu	139	14	lethal	lethal	JJ
cord-281188-0cql96hu	139	15	threshold	threshold	NN
cord-281188-0cql96hu	139	16	,	,	,
cord-281188-0cql96hu	139	17	a	a	DT
cord-281188-0cql96hu	139	18	minimum	minimum	JJ
cord-281188-0cql96hu	139	19	rate	rate	NN
cord-281188-0cql96hu	139	20	of	of	IN
cord-281188-0cql96hu	139	21	protein	protein	NN
cord-281188-0cql96hu	139	22	synthesis	synthesis	NN
cord-281188-0cql96hu	139	23	that	that	WDT
cord-281188-0cql96hu	139	24	bacteria	bacteria	NNS
cord-281188-0cql96hu	139	25	require	require	VBP
cord-281188-0cql96hu	139	26	to	to	TO
cord-281188-0cql96hu	139	27	repair	repair	VB
cord-281188-0cql96hu	139	28	or	or	CC
cord-281188-0cql96hu	139	29	compensate	compensate	VB
cord-281188-0cql96hu	139	30	structural	structural	JJ
cord-281188-0cql96hu	139	31	damage	damage	NN
cord-281188-0cql96hu	139	32	.	.	.
cord-281188-0cql96hu	140	1	In	in	IN
cord-281188-0cql96hu	140	2	the	the	DT
cord-281188-0cql96hu	140	3	absence	absence	NN
cord-281188-0cql96hu	140	4	of	of	IN
cord-281188-0cql96hu	140	5	structural	structural	JJ
cord-281188-0cql96hu	140	6	repair	repair	NN
cord-281188-0cql96hu	140	7	,	,	,
cord-281188-0cql96hu	140	8	bacteria	bacteria	NNS
cord-281188-0cql96hu	140	9	are	be	VBP
cord-281188-0cql96hu	140	10	killed	kill	VBN
cord-281188-0cql96hu	140	11	74	74	CD
cord-281188-0cql96hu	140	12	.	.	.
cord-281188-0cql96hu	141	1	Similarly	similarly	RB
cord-281188-0cql96hu	141	2	to	to	IN
cord-281188-0cql96hu	141	3	the	the	DT
cord-281188-0cql96hu	141	4	disruption	disruption	NN
cord-281188-0cql96hu	141	5	of	of	IN
cord-281188-0cql96hu	141	6	cellular	cellular	JJ
cord-281188-0cql96hu	141	7	membranes	membrane	NNS
cord-281188-0cql96hu	141	8	,	,	,
cord-281188-0cql96hu	141	9	the	the	DT
cord-281188-0cql96hu	141	10	disruption	disruption	NN
cord-281188-0cql96hu	141	11	of	of	IN
cord-281188-0cql96hu	141	12	DNA	dna	NN
cord-281188-0cql96hu	141	13	integrity	integrity	NN
cord-281188-0cql96hu	141	14	is	be	VBZ
cord-281188-0cql96hu	141	15	a	a	DT
cord-281188-0cql96hu	141	16	marker	marker	NN
cord-281188-0cql96hu	141	17	of	of	IN
cord-281188-0cql96hu	141	18	the	the	DT
cord-281188-0cql96hu	141	19	loss	loss	NN
cord-281188-0cql96hu	141	20	of	of	IN
cord-281188-0cql96hu	141	21	individuality	individuality	NN
cord-281188-0cql96hu	141	22	.	.	.
cord-281188-0cql96hu	142	1	Endogenous	endogenous	JJ
cord-281188-0cql96hu	142	2	cellular	cellular	JJ
cord-281188-0cql96hu	142	3	mechanisms	mechanism	NNS
cord-281188-0cql96hu	142	4	damage	damage	NN
cord-281188-0cql96hu	142	5	DNA	dna	NN
cord-281188-0cql96hu	142	6	integrity	integrity	NN
cord-281188-0cql96hu	142	7	,	,	,
cord-281188-0cql96hu	142	8	which	which	WDT
cord-281188-0cql96hu	142	9	can	can	MD
cord-281188-0cql96hu	142	10	be	be	VB
cord-281188-0cql96hu	142	11	the	the	DT
cord-281188-0cql96hu	142	12	result	result	NN
cord-281188-0cql96hu	142	13	of	of	IN
cord-281188-0cql96hu	142	14	a	a	DT
cord-281188-0cql96hu	142	15	stress	stress	NN
cord-281188-0cql96hu	142	16	response	response	NN
cord-281188-0cql96hu	142	17	that	that	WDT
cord-281188-0cql96hu	142	18	induces	induce	VBZ
cord-281188-0cql96hu	142	19	the	the	DT
cord-281188-0cql96hu	142	20	production	production	NN
cord-281188-0cql96hu	142	21	of	of	IN
cord-281188-0cql96hu	142	22	ROS	ROS	NNP
cord-281188-0cql96hu	142	23	(	(	-LRB-
cord-281188-0cql96hu	142	24	see	see	VB
cord-281188-0cql96hu	142	25	earlier	early	RBR
cord-281188-0cql96hu	142	26	)	)	-RRB-
cord-281188-0cql96hu	142	27	,	,	,
cord-281188-0cql96hu	142	28	reactive	reactive	JJ
cord-281188-0cql96hu	142	29	nitrogen	nitrogen	NN
cord-281188-0cql96hu	142	30	species	specie	NNS
cord-281188-0cql96hu	142	31	,	,	,
cord-281188-0cql96hu	142	32	reactive	reactive	JJ
cord-281188-0cql96hu	142	33	carbonyl	carbonyl	NN
cord-281188-0cql96hu	142	34	species	species	NN
cord-281188-0cql96hu	142	35	,	,	,
cord-281188-0cql96hu	142	36	lipid	lipid	NN
cord-281188-0cql96hu	142	37	peroxidation	peroxidation	NN
cord-281188-0cql96hu	142	38	products	product	NNS
cord-281188-0cql96hu	142	39	and	and	CC
cord-281188-0cql96hu	142	40	endonucleases	endonuclease	NNS
cord-281188-0cql96hu	142	41	.	.	.
cord-281188-0cql96hu	143	1	Of	of	RB
cord-281188-0cql96hu	143	2	course	course	RB
cord-281188-0cql96hu	143	3	,	,	,
cord-281188-0cql96hu	143	4	external	external	JJ
cord-281188-0cql96hu	143	5	conditions	condition	NNS
cord-281188-0cql96hu	143	6	can	can	MD
cord-281188-0cql96hu	143	7	also	also	RB
cord-281188-0cql96hu	143	8	damage	damage	VB
cord-281188-0cql96hu	143	9	cellular	cellular	JJ
cord-281188-0cql96hu	143	10	DNA	dna	NN
cord-281188-0cql96hu	143	11	,	,	,
cord-281188-0cql96hu	143	12	including	include	VBG
cord-281188-0cql96hu	143	13	UV	uv	NN
cord-281188-0cql96hu	143	14	light	light	NN
cord-281188-0cql96hu	143	15	,	,	,
cord-281188-0cql96hu	143	16	ionizing	ionize	VBG
cord-281188-0cql96hu	143	17	radiation	radiation	NN
cord-281188-0cql96hu	143	18	and	and	CC
cord-281188-0cql96hu	143	19	genotoxic	genotoxic	JJ
cord-281188-0cql96hu	143	20	chemicals	chemical	NNS
cord-281188-0cql96hu	143	21	.	.	.
cord-281188-0cql96hu	144	1	A	a	DT
cord-281188-0cql96hu	144	2	number	number	NN
cord-281188-0cql96hu	144	3	of	of	IN
cord-281188-0cql96hu	144	4	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	144	5	directly	directly	RB
cord-281188-0cql96hu	144	6	cause	cause	VBP
cord-281188-0cql96hu	144	7	DNA	dna	NN
cord-281188-0cql96hu	144	8	breaks	break	NNS
cord-281188-0cql96hu	144	9	,	,	,
cord-281188-0cql96hu	144	10	such	such	JJ
cord-281188-0cql96hu	144	11	as	as	IN
cord-281188-0cql96hu	144	12	bleomycin	bleomycin	NN
cord-281188-0cql96hu	144	13	.	.	.
cord-281188-0cql96hu	145	1	Also	also	RB
cord-281188-0cql96hu	145	2	,	,	,
cord-281188-0cql96hu	145	3	exposure	exposure	NN
cord-281188-0cql96hu	145	4	to	to	IN
cord-281188-0cql96hu	145	5	fluoroquinolones	fluoroquinolone	NNS
cord-281188-0cql96hu	145	6	results	result	NNS
cord-281188-0cql96hu	145	7	in	in	IN
cord-281188-0cql96hu	145	8	DNA	dna	NN
cord-281188-0cql96hu	145	9	breaks	break	VBZ
cord-281188-0cql96hu	145	10	75	75	CD
cord-281188-0cql96hu	145	11	.	.	.
cord-281188-0cql96hu	146	1	Extensive	extensive	JJ
cord-281188-0cql96hu	146	2	DNA	dna	NN
cord-281188-0cql96hu	146	3	damage	damage	NN
cord-281188-0cql96hu	146	4	can	can	MD
cord-281188-0cql96hu	146	5	induce	induce	VB
cord-281188-0cql96hu	146	6	a	a	DT
cord-281188-0cql96hu	146	7	special	special	JJ
cord-281188-0cql96hu	146	8	mode	mode	NN
cord-281188-0cql96hu	146	9	of	of	IN
cord-281188-0cql96hu	146	10	cell	cell	NN
cord-281188-0cql96hu	146	11	death	death	NN
cord-281188-0cql96hu	146	12	.	.	.
cord-281188-0cql96hu	147	1	Single	single	JJ
cord-281188-0cql96hu	147	2	-	-	HYPH
cord-281188-0cql96hu	147	3	stranded	strand	VBN
cord-281188-0cql96hu	147	4	DNA	dna	NN
cord-281188-0cql96hu	147	5	resulting	result	VBG
cord-281188-0cql96hu	147	6	from	from	IN
cord-281188-0cql96hu	147	7	damage	damage	NN
cord-281188-0cql96hu	147	8	triggers	trigger	VBZ
cord-281188-0cql96hu	147	9	the	the	DT
cord-281188-0cql96hu	147	10	protein	protein	NN
cord-281188-0cql96hu	147	11	RecA	RecA	NNP
cord-281188-0cql96hu	147	12	,	,	,
cord-281188-0cql96hu	147	13	which	which	WDT
cord-281188-0cql96hu	147	14	is	be	VBZ
cord-281188-0cql96hu	147	15	involved	involve	VBN
cord-281188-0cql96hu	147	16	www.nature.com/nrmicro	www.nature.com/nrmicro	NNP
cord-281188-0cql96hu	147	17	in	in	IN
cord-281188-0cql96hu	147	18	the	the	DT
cord-281188-0cql96hu	147	19	inactivation	inactivation	NN
cord-281188-0cql96hu	147	20	of	of	IN
cord-281188-0cql96hu	147	21	LexA.	lexa.	XX
cord-281188-0cql96hu	148	1	LexA	LexA	NNP
cord-281188-0cql96hu	148	2	is	be	VBZ
cord-281188-0cql96hu	148	3	a	a	DT
cord-281188-0cql96hu	148	4	repressor	repressor	NN
cord-281188-0cql96hu	148	5	of	of	IN
cord-281188-0cql96hu	148	6	SOS	SOS	NNP
cord-281188-0cql96hu	148	7	response	response	NN
cord-281188-0cql96hu	148	8	genes	gene	NNS
cord-281188-0cql96hu	148	9	,	,	,
cord-281188-0cql96hu	148	10	and	and	CC
cord-281188-0cql96hu	148	11	its	-PRON-	PRP$
cord-281188-0cql96hu	148	12	inactivation	inactivation	NN
cord-281188-0cql96hu	148	13	leads	lead	VBZ
cord-281188-0cql96hu	148	14	to	to	IN
cord-281188-0cql96hu	148	15	a	a	DT
cord-281188-0cql96hu	148	16	cascade	cascade	NN
cord-281188-0cql96hu	148	17	of	of	IN
cord-281188-0cql96hu	148	18	events	event	NNS
cord-281188-0cql96hu	148	19	resulting	result	VBG
cord-281188-0cql96hu	148	20	in	in	IN
cord-281188-0cql96hu	148	21	an	an	DT
cord-281188-0cql96hu	148	22	alteration	alteration	NN
cord-281188-0cql96hu	148	23	of	of	IN
cord-281188-0cql96hu	148	24	the	the	DT
cord-281188-0cql96hu	148	25	cellular	cellular	JJ
cord-281188-0cql96hu	148	26	membrane	membrane	NN
cord-281188-0cql96hu	148	27	and	and	CC
cord-281188-0cql96hu	148	28	DNA	dna	NN
cord-281188-0cql96hu	148	29	fragmentation	fragmentation	NN
cord-281188-0cql96hu	148	30	.	.	.
cord-281188-0cql96hu	149	1	LexA	LexA	NNP
cord-281188-0cql96hu	149	2	is	be	VBZ
cord-281188-0cql96hu	149	3	one	one	CD
cord-281188-0cql96hu	149	4	of	of	IN
cord-281188-0cql96hu	149	5	the	the	DT
cord-281188-0cql96hu	149	6	most	most	RBS
cord-281188-0cql96hu	149	7	over	over	RB
cord-281188-0cql96hu	149	8	-	-	HYPH
cord-281188-0cql96hu	149	9	represented	represent	VBN
cord-281188-0cql96hu	149	10	transcriptional	transcriptional	JJ
cord-281188-0cql96hu	149	11	regulators	regulator	NNS
cord-281188-0cql96hu	149	12	following	follow	VBG
cord-281188-0cql96hu	149	13	fluoroquinolones	fluoroquinolone	NNS
cord-281188-0cql96hu	149	14	treatment	treatment	NN
cord-281188-0cql96hu	149	15	76	76	CD
cord-281188-0cql96hu	149	16	.	.	.
cord-281188-0cql96hu	150	1	DNA	DNA	NNP
cord-281188-0cql96hu	150	2	double	double	JJ
cord-281188-0cql96hu	150	3	-	-	HYPH
cord-281188-0cql96hu	150	4	strand	strand	NN
cord-281188-0cql96hu	150	5	breaks	break	NNS
cord-281188-0cql96hu	150	6	can	can	MD
cord-281188-0cql96hu	150	7	also	also	RB
cord-281188-0cql96hu	150	8	be	be	VB
cord-281188-0cql96hu	150	9	produced	produce	VBN
cord-281188-0cql96hu	150	10	by	by	IN
cord-281188-0cql96hu	150	11	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	150	12	exposure	exposure	NN
cord-281188-0cql96hu	150	13	and	and	CC
cord-281188-0cql96hu	150	14	are	be	VBP
cord-281188-0cql96hu	150	15	potentially	potentially	RB
cord-281188-0cql96hu	150	16	more	more	RBR
cord-281188-0cql96hu	150	17	lethal	lethal	JJ
cord-281188-0cql96hu	150	18	than	than	IN
cord-281188-0cql96hu	150	19	single	single	JJ
cord-281188-0cql96hu	150	20	-	-	HYPH
cord-281188-0cql96hu	150	21	strand	strand	NN
cord-281188-0cql96hu	150	22	breaks	break	NNS
cord-281188-0cql96hu	150	23	.	.	.
cord-281188-0cql96hu	151	1	A	a	DT
cord-281188-0cql96hu	151	2	major	major	JJ
cord-281188-0cql96hu	151	3	inducer	inducer	NN
cord-281188-0cql96hu	151	4	of	of	IN
cord-281188-0cql96hu	151	5	the	the	DT
cord-281188-0cql96hu	151	6	SOS	SOS	NNP
cord-281188-0cql96hu	151	7	response	response	NN
cord-281188-0cql96hu	151	8	are	be	VBP
cord-281188-0cql96hu	151	9	ROS	ROS	NNP
cord-281188-0cql96hu	151	10	,	,	,
cord-281188-0cql96hu	151	11	producing	produce	VBG
cord-281188-0cql96hu	151	12	DNA	dna	NN
cord-281188-0cql96hu	151	13	double	double	JJ
cord-281188-0cql96hu	151	14	-	-	HYPH
cord-281188-0cql96hu	151	15	breaks	break	NNS
cord-281188-0cql96hu	151	16	.	.	.
cord-281188-0cql96hu	152	1	Their	-PRON-	PRP$
cord-281188-0cql96hu	152	2	(	(	-LRB-
cord-281188-0cql96hu	152	3	not	not	RB
cord-281188-0cql96hu	152	4	necessarily	necessarily	RB
cord-281188-0cql96hu	152	5	entirely	entirely	RB
cord-281188-0cql96hu	152	6	successful	successful	JJ
cord-281188-0cql96hu	152	7	)	)	-RRB-
cord-281188-0cql96hu	152	8	repair	repair	NN
cord-281188-0cql96hu	152	9	involves	involve	VBZ
cord-281188-0cql96hu	152	10	the	the	DT
cord-281188-0cql96hu	152	11	RecBCD	RecBCD	NNP
cord-281188-0cql96hu	152	12	system	system	NN
cord-281188-0cql96hu	152	13	,	,	,
cord-281188-0cql96hu	152	14	comprising	comprise	VBG
cord-281188-0cql96hu	152	15	a	a	DT
cord-281188-0cql96hu	152	16	helicase	helicase	NN
cord-281188-0cql96hu	152	17	that	that	WDT
cord-281188-0cql96hu	152	18	unwinds	unwind	VBZ
cord-281188-0cql96hu	152	19	DNA	dna	NN
cord-281188-0cql96hu	152	20	strands	strand	NNS
cord-281188-0cql96hu	152	21	and	and	CC
cord-281188-0cql96hu	152	22	a	a	DT
cord-281188-0cql96hu	152	23	nuclease	nuclease	NN
cord-281188-0cql96hu	152	24	that	that	WDT
cord-281188-0cql96hu	152	25	makes	make	VBZ
cord-281188-0cql96hu	152	26	single	single	RB
cord-281188-0cql96hu	152	27	-	-	HYPH
cord-281188-0cql96hu	152	28	stranded	strand	VBN
cord-281188-0cql96hu	152	29	nicks	nick	NNS
cord-281188-0cql96hu	152	30	77	77	CD
cord-281188-0cql96hu	152	31	.	.	.
cord-281188-0cql96hu	153	1	Probably	probably	RB
cord-281188-0cql96hu	153	2	the	the	DT
cord-281188-0cql96hu	153	3	main	main	JJ
cord-281188-0cql96hu	153	4	driver	driver	NN
cord-281188-0cql96hu	153	5	leading	lead	VBG
cord-281188-0cql96hu	153	6	to	to	IN
cord-281188-0cql96hu	153	7	double	double	JJ
cord-281188-0cql96hu	153	8	-	-	HYPH
cord-281188-0cql96hu	153	9	strand	strand	NN
cord-281188-0cql96hu	153	10	breaks	break	NNS
cord-281188-0cql96hu	153	11	is	be	VBZ
cord-281188-0cql96hu	153	12	8-oxo-2′deoxyguanosine	8-oxo-2′deoxyguanosine	CD
cord-281188-0cql96hu	153	13	,	,	,
cord-281188-0cql96hu	153	14	which	which	WDT
cord-281188-0cql96hu	153	15	is	be	VBZ
cord-281188-0cql96hu	153	16	produced	produce	VBN
cord-281188-0cql96hu	153	17	by	by	IN
cord-281188-0cql96hu	153	18	oxidation	oxidation	NN
cord-281188-0cql96hu	153	19	of	of	IN
cord-281188-0cql96hu	153	20	precursor	precursor	NN
cord-281188-0cql96hu	153	21	deoxyguanosine	deoxyguanosine	NNP
cord-281188-0cql96hu	153	22	triphosphate	triphosphate	NN
cord-281188-0cql96hu	153	23	and	and	CC
cord-281188-0cql96hu	153	24	causes	cause	VBZ
cord-281188-0cql96hu	153	25	breaks	break	NNS
cord-281188-0cql96hu	153	26	in	in	IN
cord-281188-0cql96hu	153	27	conjugation	conjugation	NN
cord-281188-0cql96hu	153	28	with	with	IN
cord-281188-0cql96hu	153	29	MutY	MutY	NNP
cord-281188-0cql96hu	153	30	and	and	CC
cord-281188-0cql96hu	153	31	MutM	MutM	NNP
cord-281188-0cql96hu	153	32	,	,	,
cord-281188-0cql96hu	153	33	proteins	protein	NNS
cord-281188-0cql96hu	153	34	involved	involve	VBN
cord-281188-0cql96hu	153	35	in	in	IN
cord-281188-0cql96hu	153	36	DNA	dna	NN
cord-281188-0cql96hu	153	37	mismatch	mismatch	NN
cord-281188-0cql96hu	153	38	repair	repair	NN
cord-281188-0cql96hu	153	39	78	78	CD
cord-281188-0cql96hu	153	40	.	.	.
cord-281188-0cql96hu	154	1	As	as	IN
cord-281188-0cql96hu	154	2	previously	previously	RB
cord-281188-0cql96hu	154	3	stated	state	VBN
cord-281188-0cql96hu	154	4	,	,	,
cord-281188-0cql96hu	154	5	it	-PRON-	PRP
cord-281188-0cql96hu	154	6	has	have	VBZ
cord-281188-0cql96hu	154	7	been	be	VBN
cord-281188-0cql96hu	154	8	proposed	propose	VBN
cord-281188-0cql96hu	154	9	that	that	IN
cord-281188-0cql96hu	154	10	some	some	DT
cord-281188-0cql96hu	154	11	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	154	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	154	13	ultimately	ultimately	RB
cord-281188-0cql96hu	154	14	kill	kill	VBP
cord-281188-0cql96hu	154	15	bacteria	bacteria	NNS
cord-281188-0cql96hu	154	16	by	by	IN
cord-281188-0cql96hu	154	17	generating	generate	VBG
cord-281188-0cql96hu	154	18	DNA	dna	NN
cord-281188-0cql96hu	154	19	double	double	JJ
cord-281188-0cql96hu	154	20	-	-	HYPH
cord-281188-0cql96hu	154	21	strand	strand	NN
cord-281188-0cql96hu	154	22	breaks	break	NNS
cord-281188-0cql96hu	154	23	;	;	:
cord-281188-0cql96hu	154	24	chemicals	chemical	NNS
cord-281188-0cql96hu	154	25	producing	produce	VBG
cord-281188-0cql96hu	154	26	breaks	break	NNS
cord-281188-0cql96hu	154	27	are	be	VBP
cord-281188-0cql96hu	154	28	synergistic	synergistic	JJ
cord-281188-0cql96hu	154	29	with	with	IN
cord-281188-0cql96hu	154	30	these	these	DT
cord-281188-0cql96hu	154	31	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	154	32	79	79	CD
cord-281188-0cql96hu	154	33	,	,	,
cord-281188-0cql96hu	154	34	and	and	CC
cord-281188-0cql96hu	154	35	thus	thus	RB
cord-281188-0cql96hu	154	36	it	-PRON-	PRP
cord-281188-0cql96hu	154	37	can	can	MD
cord-281188-0cql96hu	154	38	be	be	VB
cord-281188-0cql96hu	154	39	expected	expect	VBN
cord-281188-0cql96hu	154	40	that	that	IN
cord-281188-0cql96hu	154	41	a	a	DT
cord-281188-0cql96hu	154	42	shortage	shortage	NN
cord-281188-0cql96hu	154	43	of	of	IN
cord-281188-0cql96hu	154	44	protein	protein	NN
cord-281188-0cql96hu	154	45	synthesis	synthesis	NN
cord-281188-0cql96hu	154	46	might	may	MD
cord-281188-0cql96hu	154	47	reduce	reduce	VB
cord-281188-0cql96hu	154	48	repair	repair	NN
cord-281188-0cql96hu	154	49	functions	function	NNS
cord-281188-0cql96hu	154	50	,	,	,
cord-281188-0cql96hu	154	51	contributing	contribute	VBG
cord-281188-0cql96hu	154	52	to	to	IN
cord-281188-0cql96hu	154	53	cell	cell	NN
cord-281188-0cql96hu	154	54	death	death	NN
cord-281188-0cql96hu	154	55	74	74	CD
cord-281188-0cql96hu	154	56	.	.	.
cord-281188-0cql96hu	155	1	However	however	RB
cord-281188-0cql96hu	155	2	,	,	,
cord-281188-0cql96hu	155	3	this	this	DT
cord-281188-0cql96hu	155	4	effect	effect	NN
cord-281188-0cql96hu	155	5	is	be	VBZ
cord-281188-0cql96hu	155	6	not	not	RB
cord-281188-0cql96hu	155	7	always	always	RB
cord-281188-0cql96hu	155	8	apparent	apparent	JJ
cord-281188-0cql96hu	155	9	in	in	IN
cord-281188-0cql96hu	155	10	studies	study	NNS
cord-281188-0cql96hu	155	11	using	use	VBG
cord-281188-0cql96hu	155	12	combinations	combination	NNS
cord-281188-0cql96hu	155	13	of	of	IN
cord-281188-0cql96hu	155	14	protein	protein	NN
cord-281188-0cql96hu	155	15	-	-	HYPH
cord-281188-0cql96hu	155	16	inhibiting	inhibit	VBG
cord-281188-0cql96hu	155	17	drugs	drug	NNS
cord-281188-0cql96hu	155	18	with	with	IN
cord-281188-0cql96hu	155	19	DNA	dna	NN
cord-281188-0cql96hu	155	20	-	-	HYPH
cord-281188-0cql96hu	155	21	damaging	damage	VBG
cord-281188-0cql96hu	155	22	antimicrobials	antimicrobial	NNS
cord-281188-0cql96hu	155	23	or	or	CC
cord-281188-0cql96hu	155	24	chemical	chemical	NN
cord-281188-0cql96hu	155	25	mutagens	mutagen	NNS
cord-281188-0cql96hu	155	26	79	79	CD
cord-281188-0cql96hu	155	27	,	,	,
cord-281188-0cql96hu	155	28	80	80	CD
cord-281188-0cql96hu	155	29	.	.	.
cord-281188-0cql96hu	156	1	Perhaps	perhaps	RB
cord-281188-0cql96hu	156	2	sequential	sequential	JJ
cord-281188-0cql96hu	156	3	rather	rather	RB
cord-281188-0cql96hu	156	4	than	than	IN
cord-281188-0cql96hu	156	5	simultaneous	simultaneous	JJ
cord-281188-0cql96hu	156	6	exposure	exposure	NN
cord-281188-0cql96hu	156	7	of	of	IN
cord-281188-0cql96hu	156	8	DNA	dna	NN
cord-281188-0cql96hu	156	9	breaking	breaking	NN
cord-281188-0cql96hu	156	10	and	and	CC
cord-281188-0cql96hu	156	11	protein	protein	NN
cord-281188-0cql96hu	156	12	synthesis	synthesis	NN
cord-281188-0cql96hu	156	13	-	-	HYPH
cord-281188-0cql96hu	156	14	inhibiting	inhibit	VBG
cord-281188-0cql96hu	156	15	drugs	drug	NNS
cord-281188-0cql96hu	156	16	would	would	MD
cord-281188-0cql96hu	156	17	be	be	VB
cord-281188-0cql96hu	156	18	a	a	DT
cord-281188-0cql96hu	156	19	more	more	RBR
cord-281188-0cql96hu	156	20	effective	effective	JJ
cord-281188-0cql96hu	156	21	way	way	NN
cord-281188-0cql96hu	156	22	to	to	TO
cord-281188-0cql96hu	156	23	use	use	VB
cord-281188-0cql96hu	156	24	combinations	combination	NNS
cord-281188-0cql96hu	156	25	of	of	IN
cord-281188-0cql96hu	156	26	these	these	DT
cord-281188-0cql96hu	156	27	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	156	28	with	with	IN
cord-281188-0cql96hu	156	29	these	these	DT
cord-281188-0cql96hu	156	30	different	different	JJ
cord-281188-0cql96hu	156	31	modes	mode	NNS
cord-281188-0cql96hu	156	32	of	of	IN
cord-281188-0cql96hu	156	33	action	action	NN
cord-281188-0cql96hu	156	34	.	.	.
cord-281188-0cql96hu	157	1	It	-PRON-	PRP
cord-281188-0cql96hu	157	2	may	may	MD
cord-281188-0cql96hu	157	3	well	well	RB
cord-281188-0cql96hu	157	4	be	be	VB
cord-281188-0cql96hu	157	5	that	that	IN
cord-281188-0cql96hu	157	6	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	157	7	that	that	WDT
cord-281188-0cql96hu	157	8	drive	drive	VBP
cord-281188-0cql96hu	157	9	bacteria	bacteria	NNS
cord-281188-0cql96hu	157	10	into	into	IN
cord-281188-0cql96hu	157	11	an	an	DT
cord-281188-0cql96hu	157	12	unspecific	unspecific	JJ
cord-281188-0cql96hu	157	13	stress	stress	NN
cord-281188-0cql96hu	157	14	status	status	NN
cord-281188-0cql96hu	157	15	mimic	mimic	VBP
cord-281188-0cql96hu	157	16	other	other	JJ
cord-281188-0cql96hu	157	17	conditions	condition	NNS
cord-281188-0cql96hu	157	18	as	as	IN
cord-281188-0cql96hu	157	19	oligothropy	oligothropy	NN
cord-281188-0cql96hu	157	20	or	or	CC
cord-281188-0cql96hu	157	21	starvation	starvation	NN
cord-281188-0cql96hu	157	22	reduce	reduce	VBP
cord-281188-0cql96hu	157	23	the	the	DT
cord-281188-0cql96hu	157	24	viability	viability	NN
cord-281188-0cql96hu	157	25	of	of	IN
cord-281188-0cql96hu	157	26	bacteria	bacteria	NNS
cord-281188-0cql96hu	157	27	by	by	IN
cord-281188-0cql96hu	157	28	reducing	reduce	VBG
cord-281188-0cql96hu	157	29	the	the	DT
cord-281188-0cql96hu	157	30	availability	availability	NN
cord-281188-0cql96hu	157	31	of	of	IN
cord-281188-0cql96hu	157	32	nutrients	nutrient	NNS
cord-281188-0cql96hu	157	33	required	require	VBN
cord-281188-0cql96hu	157	34	for	for	IN
cord-281188-0cql96hu	157	35	essential	essential	JJ
cord-281188-0cql96hu	157	36	energy	energy	NN
cord-281188-0cql96hu	157	37	-	-	HYPH
cord-281188-0cql96hu	157	38	consuming	consume	VBG
cord-281188-0cql96hu	157	39	functions	function	NNS
cord-281188-0cql96hu	157	40	,	,	,
cord-281188-0cql96hu	157	41	including	include	VBG
cord-281188-0cql96hu	157	42	DNA	dna	NN
cord-281188-0cql96hu	157	43	repair	repair	NN
cord-281188-0cql96hu	157	44	81	81	CD
cord-281188-0cql96hu	157	45	.	.	.
cord-281188-0cql96hu	158	1	Certainly	certainly	RB
cord-281188-0cql96hu	158	2	,	,	,
cord-281188-0cql96hu	158	3	E.	E.	NNP
cord-281188-0cql96hu	158	4	coli	coli	NNS
cord-281188-0cql96hu	158	5	has	have	VBZ
cord-281188-0cql96hu	158	6	excess	excess	JJ
cord-281188-0cql96hu	158	7	capacity	capacity	NN
cord-281188-0cql96hu	158	8	for	for	IN
cord-281188-0cql96hu	158	9	DNA	dna	NN
cord-281188-0cql96hu	158	10	repair	repair	NN
cord-281188-0cql96hu	158	11	,	,	,
cord-281188-0cql96hu	158	12	which	which	WDT
cord-281188-0cql96hu	158	13	compensates	compensate	VBZ
cord-281188-0cql96hu	158	14	DNA	dna	NN
cord-281188-0cql96hu	158	15	damage	damage	NN
cord-281188-0cql96hu	158	16	from	from	IN
cord-281188-0cql96hu	158	17	nutritional	nutritional	JJ
cord-281188-0cql96hu	158	18	stress	stress	NN
cord-281188-0cql96hu	158	19	82	82	CD
cord-281188-0cql96hu	158	20	.	.	.
cord-281188-0cql96hu	159	1	Perhaps	perhaps	RB
cord-281188-0cql96hu	159	2	exposure	exposure	NN
cord-281188-0cql96hu	159	3	to	to	IN
cord-281188-0cql96hu	159	4	DNA	dna	NN
cord-281188-0cql96hu	159	5	-	-	HYPH
cord-281188-0cql96hu	159	6	breaking	break	VBG
cord-281188-0cql96hu	159	7	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	159	8	can	can	MD
cord-281188-0cql96hu	159	9	surpass	surpass	VB
cord-281188-0cql96hu	159	10	this	this	DT
cord-281188-0cql96hu	159	11	repair	repair	NN
cord-281188-0cql96hu	159	12	capacity	capacity	NN
cord-281188-0cql96hu	159	13	.	.	.
cord-281188-0cql96hu	160	1	A	a	DT
cord-281188-0cql96hu	160	2	paradox	paradox	NN
cord-281188-0cql96hu	160	3	that	that	WDT
cord-281188-0cql96hu	160	4	is	be	VBZ
cord-281188-0cql96hu	160	5	observed	observe	VBN
cord-281188-0cql96hu	160	6	across	across	IN
cord-281188-0cql96hu	160	7	all	all	DT
cord-281188-0cql96hu	160	8	fields	field	NNS
cord-281188-0cql96hu	160	9	of	of	IN
cord-281188-0cql96hu	160	10	biology	biology	NN
cord-281188-0cql96hu	160	11	(	(	-LRB-
cord-281188-0cql96hu	160	12	including	include	VBG
cord-281188-0cql96hu	160	13	human	human	JJ
cord-281188-0cql96hu	160	14	infections	infection	NNS
cord-281188-0cql96hu	160	15	,	,	,
cord-281188-0cql96hu	160	16	such	such	JJ
cord-281188-0cql96hu	160	17	as	as	IN
cord-281188-0cql96hu	160	18	sepsis	sepsis	NN
cord-281188-0cql96hu	160	19	)	)	-RRB-
cord-281188-0cql96hu	160	20	is	be	VBZ
cord-281188-0cql96hu	160	21	that	that	IN
cord-281188-0cql96hu	160	22	the	the	DT
cord-281188-0cql96hu	160	23	very	very	RB
cord-281188-0cql96hu	160	24	same	same	JJ
cord-281188-0cql96hu	160	25	mechanisms	mechanism	NNS
cord-281188-0cql96hu	160	26	responsible	responsible	JJ
cord-281188-0cql96hu	160	27	for	for	IN
cord-281188-0cql96hu	160	28	physiological	physiological	JJ
cord-281188-0cql96hu	160	29	adaptation	adaptation	NN
cord-281188-0cql96hu	160	30	,	,	,
cord-281188-0cql96hu	160	31	defence	defence	NN
cord-281188-0cql96hu	160	32	and	and	CC
cord-281188-0cql96hu	160	33	damage	damage	NN
cord-281188-0cql96hu	160	34	repair	repair	NN
cord-281188-0cql96hu	160	35	on	on	IN
cord-281188-0cql96hu	160	36	crossing	cross	VBG
cord-281188-0cql96hu	160	37	a	a	DT
cord-281188-0cql96hu	160	38	threshold	threshold	NN
cord-281188-0cql96hu	160	39	promote	promote	NN
cord-281188-0cql96hu	160	40	death	death	NN
cord-281188-0cql96hu	160	41	83	83	CD
cord-281188-0cql96hu	160	42	.	.	.
cord-281188-0cql96hu	161	1	In	in	IN
cord-281188-0cql96hu	161	2	this	this	DT
cord-281188-0cql96hu	161	3	interpretation	interpretation	NN
cord-281188-0cql96hu	161	4	,	,	,
cord-281188-0cql96hu	161	5	some	some	DT
cord-281188-0cql96hu	161	6	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	161	7	kill	kill	VBP
cord-281188-0cql96hu	161	8	by	by	IN
cord-281188-0cql96hu	161	9	generating	generate	VBG
cord-281188-0cql96hu	161	10	an	an	DT
cord-281188-0cql96hu	161	11	irreversible	irreversible	JJ
cord-281188-0cql96hu	161	12	cascade	cascade	NN
cord-281188-0cql96hu	161	13	of	of	IN
cord-281188-0cql96hu	161	14	events	event	NNS
cord-281188-0cql96hu	161	15	;	;	:
cord-281188-0cql96hu	161	16	for	for	IN
cord-281188-0cql96hu	161	17	example	example	NN
cord-281188-0cql96hu	161	18	,	,	,
cord-281188-0cql96hu	161	19	chromosomal	chromosomal	JJ
cord-281188-0cql96hu	161	20	lesions	lesion	NNS
cord-281188-0cql96hu	161	21	trigger	trigger	VBP
cord-281188-0cql96hu	161	22	the	the	DT
cord-281188-0cql96hu	161	23	production	production	NN
cord-281188-0cql96hu	161	24	of	of	IN
cord-281188-0cql96hu	161	25	ROS	ROS	NNP
cord-281188-0cql96hu	161	26	,	,	,
cord-281188-0cql96hu	161	27	which	which	WDT
cord-281188-0cql96hu	161	28	damages	damage	VBZ
cord-281188-0cql96hu	161	29	DNA	dna	NN
cord-281188-0cql96hu	161	30	,	,	,
cord-281188-0cql96hu	161	31	which	which	WDT
cord-281188-0cql96hu	161	32	in	in	IN
cord-281188-0cql96hu	161	33	turn	turn	NN
cord-281188-0cql96hu	161	34	triggers	trigger	VBZ
cord-281188-0cql96hu	161	35	the	the	DT
cord-281188-0cql96hu	161	36	release	release	NN
cord-281188-0cql96hu	161	37	of	of	IN
cord-281188-0cql96hu	161	38	SOS	SOS	NNP
cord-281188-0cql96hu	161	39	response	response	NN
cord-281188-0cql96hu	161	40	products	product	NNS
cord-281188-0cql96hu	161	41	intending	intend	VBG
cord-281188-0cql96hu	161	42	to	to	TO
cord-281188-0cql96hu	161	43	rescue	rescue	VB
cord-281188-0cql96hu	161	44	the	the	DT
cord-281188-0cql96hu	161	45	cell	cell	NN
cord-281188-0cql96hu	161	46	from	from	IN
cord-281188-0cql96hu	161	47	death	death	NN
cord-281188-0cql96hu	161	48	,	,	,
cord-281188-0cql96hu	161	49	but	but	CC
cord-281188-0cql96hu	161	50	(	(	-LRB-
cord-281188-0cql96hu	161	51	not	not	RB
cord-281188-0cql96hu	161	52	fully	fully	RB
cord-281188-0cql96hu	161	53	demonstrated	demonstrate	VBN
cord-281188-0cql96hu	161	54	)	)	-RRB-
cord-281188-0cql96hu	161	55	under	under	IN
cord-281188-0cql96hu	161	56	high	high	JJ
cord-281188-0cql96hu	161	57	cytotoxicity	cytotoxicity	NN
cord-281188-0cql96hu	161	58	could	could	MD
cord-281188-0cql96hu	161	59	lead	lead	VB
cord-281188-0cql96hu	161	60	to	to	IN
cord-281188-0cql96hu	161	61	destabilization	destabilization	NN
cord-281188-0cql96hu	161	62	of	of	IN
cord-281188-0cql96hu	161	63	homeostasis	homeostasis	NN
cord-281188-0cql96hu	161	64	,	,	,
cord-281188-0cql96hu	161	65	including	include	VBG
cord-281188-0cql96hu	161	66	iron	iron	NN
cord-281188-0cql96hu	161	67	-	-	HYPH
cord-281188-0cql96hu	161	68	sulfur	sulfur	NN
cord-281188-0cql96hu	161	69	clusters	cluster	NNS
cord-281188-0cql96hu	161	70	,	,	,
cord-281188-0cql96hu	161	71	eventually	eventually	RB
cord-281188-0cql96hu	161	72	increasing	increase	VBG
cord-281188-0cql96hu	161	73	ROS	ROS	NNP
cord-281188-0cql96hu	161	74	levels	level	NNS
cord-281188-0cql96hu	161	75	further	further	RB
cord-281188-0cql96hu	161	76	,	,	,
cord-281188-0cql96hu	161	77	resulting	result	VBG
cord-281188-0cql96hu	161	78	in	in	IN
cord-281188-0cql96hu	161	79	more	more	JJR
cord-281188-0cql96hu	161	80	chromosomal	chromosomal	JJ
cord-281188-0cql96hu	161	81	breaks	break	NNS
cord-281188-0cql96hu	161	82	.	.	.
cord-281188-0cql96hu	162	1	Is	be	VBZ
cord-281188-0cql96hu	162	2	there	there	EX
cord-281188-0cql96hu	162	3	a	a	DT
cord-281188-0cql96hu	162	4	unique	unique	JJ
cord-281188-0cql96hu	162	5	mechanism	mechanism	NN
cord-281188-0cql96hu	162	6	by	by	IN
cord-281188-0cql96hu	162	7	which	which	WDT
cord-281188-0cql96hu	162	8	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	162	9	prevent	prevent	VBP
cord-281188-0cql96hu	162	10	the	the	DT
cord-281188-0cql96hu	162	11	replication	replication	NN
cord-281188-0cql96hu	162	12	of	of	IN
cord-281188-0cql96hu	162	13	bacteria	bacteria	NNS
cord-281188-0cql96hu	162	14	?	?	.
cord-281188-0cql96hu	163	1	A	a	DT
cord-281188-0cql96hu	163	2	few	few	JJ
cord-281188-0cql96hu	163	3	years	year	NNS
cord-281188-0cql96hu	163	4	ago	ago	RB
cord-281188-0cql96hu	163	5	,	,	,
cord-281188-0cql96hu	163	6	along	along	IN
cord-281188-0cql96hu	163	7	with	with	IN
cord-281188-0cql96hu	163	8	other	other	JJ
cord-281188-0cql96hu	163	9	colleagues	colleague	NNS
cord-281188-0cql96hu	163	10	,	,	,
cord-281188-0cql96hu	163	11	we	-PRON-	PRP
cord-281188-0cql96hu	163	12	presented	present	VBD
cord-281188-0cql96hu	163	13	a	a	DT
cord-281188-0cql96hu	163	14	hypothesis	hypothesis	NN
cord-281188-0cql96hu	163	15	for	for	IN
cord-281188-0cql96hu	163	16	how	how	WRB
cord-281188-0cql96hu	163	17	ribosome	ribosome	NN
cord-281188-0cql96hu	163	18	-	-	HYPH
cord-281188-0cql96hu	163	19	targeting	target	VBG
cord-281188-0cql96hu	163	20	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	163	21	that	that	WDT
cord-281188-0cql96hu	163	22	are	be	VBP
cord-281188-0cql96hu	163	23	deemed	deem	VBN
cord-281188-0cql96hu	163	24	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	163	25	not	not	RB
cord-281188-0cql96hu	163	26	only	only	RB
cord-281188-0cql96hu	163	27	prevent	prevent	VB
cord-281188-0cql96hu	163	28	the	the	DT
cord-281188-0cql96hu	163	29	replication	replication	NN
cord-281188-0cql96hu	163	30	of	of	IN
cord-281188-0cql96hu	163	31	bacteria	bacteria	NNS
cord-281188-0cql96hu	163	32	but	but	CC
cord-281188-0cql96hu	163	33	might	may	MD
cord-281188-0cql96hu	163	34	also	also	RB
cord-281188-0cql96hu	163	35	be	be	VB
cord-281188-0cql96hu	163	36	lethal	lethal	JJ
cord-281188-0cql96hu	163	37	3	3	CD
cord-281188-0cql96hu	163	38	.	.	.
cord-281188-0cql96hu	164	1	In	in	IN
cord-281188-0cql96hu	164	2	accord	accord	NN
cord-281188-0cql96hu	164	3	with	with	IN
cord-281188-0cql96hu	164	4	our	-PRON-	PRP$
cord-281188-0cql96hu	164	5	hypothesis	hypothesis	NN
cord-281188-0cql96hu	164	6	,	,	,
cord-281188-0cql96hu	164	7	these	these	DT
cord-281188-0cql96hu	164	8	drugs	drug	NNS
cord-281188-0cql96hu	164	9	tie	tie	VBP
cord-281188-0cql96hu	164	10	up	up	RP
cord-281188-0cql96hu	164	11	enough	enough	JJ
cord-281188-0cql96hu	164	12	ribosomes	ribosome	NNS
cord-281188-0cql96hu	164	13	for	for	IN
cord-281188-0cql96hu	164	14	cells	cell	NNS
cord-281188-0cql96hu	164	15	not	not	RB
cord-281188-0cql96hu	164	16	to	to	TO
cord-281188-0cql96hu	164	17	be	be	VB
cord-281188-0cql96hu	164	18	able	able	JJ
cord-281188-0cql96hu	164	19	to	to	TO
cord-281188-0cql96hu	164	20	synthesize	synthesize	VB
cord-281188-0cql96hu	164	21	enough	enough	JJ
cord-281188-0cql96hu	164	22	essential	essential	JJ
cord-281188-0cql96hu	164	23	enzymes	enzyme	NNS
cord-281188-0cql96hu	164	24	and	and	CC
cord-281188-0cql96hu	164	25	other	other	JJ
cord-281188-0cql96hu	164	26	proteins	protein	NNS
cord-281188-0cql96hu	164	27	required	require	VBN
cord-281188-0cql96hu	164	28	for	for	IN
cord-281188-0cql96hu	164	29	replication	replication	NN
cord-281188-0cql96hu	164	30	or	or	CC
cord-281188-0cql96hu	164	31	to	to	TO
cord-281188-0cql96hu	164	32	ensure	ensure	VB
cord-281188-0cql96hu	164	33	the	the	DT
cord-281188-0cql96hu	164	34	healthy	healthy	JJ
cord-281188-0cql96hu	164	35	turnover	turnover	NN
cord-281188-0cql96hu	164	36	of	of	IN
cord-281188-0cql96hu	164	37	envelope	envelope	NN
cord-281188-0cql96hu	164	38	components	component	NNS
cord-281188-0cql96hu	164	39	,	,	,
cord-281188-0cql96hu	164	40	including	include	VBG
cord-281188-0cql96hu	164	41	the	the	DT
cord-281188-0cql96hu	164	42	most	most	RBS
cord-281188-0cql96hu	164	43	frequently	frequently	RB
cord-281188-0cql96hu	164	44	transcribed	transcribe	VBN
cord-281188-0cql96hu	164	45	proteins	protein	NNS
cord-281188-0cql96hu	164	46	in	in	IN
cord-281188-0cql96hu	164	47	the	the	DT
cord-281188-0cql96hu	164	48	cell	cell	NN
cord-281188-0cql96hu	164	49	,	,	,
cord-281188-0cql96hu	164	50	ribosome	ribosome	NN
cord-281188-0cql96hu	164	51	proteins	protein	NNS
cord-281188-0cql96hu	164	52	and	and	CC
cord-281188-0cql96hu	164	53	membrane	membrane	NN
cord-281188-0cql96hu	164	54	lipoproteins	lipoprotein	NNS
cord-281188-0cql96hu	164	55	84	84	CD
cord-281188-0cql96hu	164	56	.	.	.
cord-281188-0cql96hu	165	1	As	as	IN
cord-281188-0cql96hu	165	2	predicted	predict	VBN
cord-281188-0cql96hu	165	3	by	by	IN
cord-281188-0cql96hu	165	4	the	the	DT
cord-281188-0cql96hu	165	5	model	model	NN
cord-281188-0cql96hu	165	6	on	on	IN
cord-281188-0cql96hu	165	7	which	which	WDT
cord-281188-0cql96hu	165	8	this	this	DT
cord-281188-0cql96hu	165	9	'	'	``
cord-281188-0cql96hu	165	10	numbers	number	NNS
cord-281188-0cql96hu	165	11	game	game	NN
cord-281188-0cql96hu	165	12	'	'	''
cord-281188-0cql96hu	165	13	hypothesis	hypothesis	NN
cord-281188-0cql96hu	165	14	was	be	VBD
cord-281188-0cql96hu	165	15	based	base	VBN
cord-281188-0cql96hu	165	16	,	,	,
cord-281188-0cql96hu	165	17	as	as	IN
cord-281188-0cql96hu	165	18	the	the	DT
cord-281188-0cql96hu	165	19	number	number	NN
cord-281188-0cql96hu	165	20	of	of	IN
cord-281188-0cql96hu	165	21	ribosomes	ribosome	NNS
cord-281188-0cql96hu	165	22	is	be	VBZ
cord-281188-0cql96hu	165	23	reduced	reduce	VBN
cord-281188-0cql96hu	165	24	,	,	,
cord-281188-0cql96hu	165	25	ribosome	ribosome	NN
cord-281188-0cql96hu	165	26	-	-	HYPH
cord-281188-0cql96hu	165	27	targeting	target	VBG
cord-281188-0cql96hu	165	28	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	165	29	will	will	MD
cord-281188-0cql96hu	165	30	become	become	VB
cord-281188-0cql96hu	165	31	increasingly	increasingly	RB
cord-281188-0cql96hu	165	32	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	165	33	.	.	.
cord-281188-0cql96hu	166	1	Two	two	CD
cord-281188-0cql96hu	166	2	lines	line	NNS
cord-281188-0cql96hu	166	3	of	of	IN
cord-281188-0cql96hu	166	4	evidence	evidence	NN
cord-281188-0cql96hu	166	5	were	be	VBD
cord-281188-0cql96hu	166	6	presented	present	VBN
cord-281188-0cql96hu	166	7	in	in	IN
cord-281188-0cql96hu	166	8	support	support	NN
cord-281188-0cql96hu	166	9	of	of	IN
cord-281188-0cql96hu	166	10	this	this	DT
cord-281188-0cql96hu	166	11	hypothesis	hypothesis	NN
cord-281188-0cql96hu	166	12	,	,	,
cord-281188-0cql96hu	166	13	both	both	DT
cord-281188-0cql96hu	166	14	of	of	IN
cord-281188-0cql96hu	166	15	which	which	WDT
cord-281188-0cql96hu	166	16	were	be	VBD
cord-281188-0cql96hu	166	17	based	base	VBN
cord-281188-0cql96hu	166	18	on	on	IN
cord-281188-0cql96hu	166	19	the	the	DT
cord-281188-0cql96hu	166	20	number	number	NN
cord-281188-0cql96hu	166	21	of	of	IN
cord-281188-0cql96hu	166	22	ribosomal	ribosomal	JJ
cord-281188-0cql96hu	166	23	RNA	RNA	NNP
cord-281188-0cql96hu	166	24	(	(	-LRB-
cord-281188-0cql96hu	166	25	rrn	rrn	NN
cord-281188-0cql96hu	166	26	)	)	-RRB-
cord-281188-0cql96hu	166	27	operons	operon	NNS
cord-281188-0cql96hu	166	28	.	.	.
cord-281188-0cql96hu	167	1	E.	E.	NNP
cord-281188-0cql96hu	167	2	coli	coli	VBZ
cord-281188-0cql96hu	167	3	strains	strain	NNS
cord-281188-0cql96hu	167	4	with	with	IN
cord-281188-0cql96hu	167	5	deletions	deletion	NNS
cord-281188-0cql96hu	167	6	of	of	IN
cord-281188-0cql96hu	167	7	five	five	CD
cord-281188-0cql96hu	167	8	or	or	CC
cord-281188-0cql96hu	167	9	six	six	CD
cord-281188-0cql96hu	167	10	of	of	IN
cord-281188-0cql96hu	167	11	the	the	DT
cord-281188-0cql96hu	167	12	seven	seven	CD
cord-281188-0cql96hu	167	13	rrn	rrn	NN
cord-281188-0cql96hu	167	14	operons	operon	NNS
cord-281188-0cql96hu	167	15	85	85	CD
cord-281188-0cql96hu	167	16	were	be	VBD
cord-281188-0cql96hu	167	17	killed	kill	VBN
cord-281188-0cql96hu	167	18	at	at	IN
cord-281188-0cql96hu	167	19	a	a	DT
cord-281188-0cql96hu	167	20	higher	high	JJR
cord-281188-0cql96hu	167	21	rate	rate	NN
cord-281188-0cql96hu	167	22	by	by	IN
cord-281188-0cql96hu	167	23	azithromycin	azithromycin	NNP
cord-281188-0cql96hu	167	24	,	,	,
cord-281188-0cql96hu	167	25	chloramphenicol	chloramphenicol	NN
cord-281188-0cql96hu	167	26	and	and	CC
cord-281188-0cql96hu	167	27	tetracycline	tetracycline	NN
cord-281188-0cql96hu	167	28	than	than	IN
cord-281188-0cql96hu	167	29	the	the	DT
cord-281188-0cql96hu	167	30	ancestral	ancestral	JJ
cord-281188-0cql96hu	167	31	MG1655	MG1655	NNP
cord-281188-0cql96hu	167	32	strain	strain	NN
cord-281188-0cql96hu	167	33	or	or	CC
cord-281188-0cql96hu	167	34	strains	strain	NNS
cord-281188-0cql96hu	167	35	with	with	IN
cord-281188-0cql96hu	167	36	more	more	JJR
cord-281188-0cql96hu	167	37	than	than	IN
cord-281188-0cql96hu	167	38	two	two	CD
cord-281188-0cql96hu	167	39	rrn	rrn	NN
cord-281188-0cql96hu	167	40	operons	operon	NNS
cord-281188-0cql96hu	167	41	.	.	.
cord-281188-0cql96hu	168	1	In	in	IN
cord-281188-0cql96hu	168	2	C.	C.	NNP
cord-281188-0cql96hu	168	3	jejuni	jejuni	NNP
cord-281188-0cql96hu	168	4	,	,	,
cord-281188-0cql96hu	168	5	which	which	WDT
cord-281188-0cql96hu	168	6	has	have	VBZ
cord-281188-0cql96hu	168	7	three	three	CD
cord-281188-0cql96hu	168	8	rrn	rrn	NN
cord-281188-0cql96hu	168	9	operons	operon	NNS
cord-281188-0cql96hu	168	10	rather	rather	RB
cord-281188-0cql96hu	168	11	than	than	IN
cord-281188-0cql96hu	168	12	seven	seven	CD
cord-281188-0cql96hu	168	13	as	as	IN
cord-281188-0cql96hu	168	14	in	in	IN
cord-281188-0cql96hu	168	15	E.	E.	NNP
cord-281188-0cql96hu	168	16	coli	coli	NNS
cord-281188-0cql96hu	168	17	,	,	,
cord-281188-0cql96hu	168	18	chloramphenicol	chloramphenicol	NN
cord-281188-0cql96hu	168	19	and	and	CC
cord-281188-0cql96hu	168	20	azithromycin	azithromycin	NNS
cord-281188-0cql96hu	168	21	are	be	VBP
cord-281188-0cql96hu	168	22	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	168	23	rather	rather	RB
cord-281188-0cql96hu	168	24	than	than	IN
cord-281188-0cql96hu	168	25	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	168	26	as	as	IN
cord-281188-0cql96hu	168	27	they	-PRON-	PRP
cord-281188-0cql96hu	168	28	are	be	VBP
cord-281188-0cql96hu	168	29	for	for	IN
cord-281188-0cql96hu	168	30	E.	E.	NNP
cord-281188-0cql96hu	168	31	coli	coli	VBZ
cord-281188-0cql96hu	168	32	3	3	CD
cord-281188-0cql96hu	168	33	.	.	.
cord-281188-0cql96hu	169	1	These	these	DT
cord-281188-0cql96hu	169	2	results	result	NNS
cord-281188-0cql96hu	169	3	suggest	suggest	VBP
cord-281188-0cql96hu	169	4	that	that	IN
cord-281188-0cql96hu	169	5	a	a	DT
cord-281188-0cql96hu	169	6	low	low	JJ
cord-281188-0cql96hu	169	7	number	number	NN
cord-281188-0cql96hu	169	8	of	of	IN
cord-281188-0cql96hu	169	9	functional	functional	JJ
cord-281188-0cql96hu	169	10	ribosomes	ribosome	NNS
cord-281188-0cql96hu	169	11	might	may	MD
cord-281188-0cql96hu	169	12	lead	lead	VB
cord-281188-0cql96hu	169	13	to	to	IN
cord-281188-0cql96hu	169	14	a	a	DT
cord-281188-0cql96hu	169	15	kind	kind	NN
cord-281188-0cql96hu	169	16	of	of	IN
cord-281188-0cql96hu	169	17	lethal	lethal	JJ
cord-281188-0cql96hu	169	18	protein	protein	NN
cord-281188-0cql96hu	169	19	synthesis	synthesis	NN
cord-281188-0cql96hu	169	20	threshold	threshold	NN
cord-281188-0cql96hu	169	21	.	.	.
cord-281188-0cql96hu	170	1	But	but	CC
cord-281188-0cql96hu	170	2	we	-PRON-	PRP
cord-281188-0cql96hu	170	3	restrained	restrain	VBD
cord-281188-0cql96hu	170	4	ourselves	-PRON-	PRP
cord-281188-0cql96hu	170	5	from	from	IN
cord-281188-0cql96hu	170	6	asserting	assert	VBG
cord-281188-0cql96hu	170	7	that	that	IN
cord-281188-0cql96hu	170	8	crossing	cross	VBG
cord-281188-0cql96hu	170	9	this	this	DT
cord-281188-0cql96hu	170	10	threshold	threshold	NN
cord-281188-0cql96hu	170	11	is	be	VBZ
cord-281188-0cql96hu	170	12	the	the	DT
cord-281188-0cql96hu	170	13	ultimate	ultimate	JJ
cord-281188-0cql96hu	170	14	mechanism	mechanism	NN
cord-281188-0cql96hu	170	15	by	by	IN
cord-281188-0cql96hu	170	16	which	which	WDT
cord-281188-0cql96hu	170	17	these	these	DT
cord-281188-0cql96hu	170	18	ribosome	ribosome	NN
cord-281188-0cql96hu	170	19	-	-	HYPH
cord-281188-0cql96hu	170	20	targeting	target	VBG
cord-281188-0cql96hu	170	21	'	'	``
cord-281188-0cql96hu	170	22	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	170	23	'	'	''
cord-281188-0cql96hu	170	24	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	170	25	kill	kill	VBP
cord-281188-0cql96hu	170	26	bacteria	bacteria	NNS
cord-281188-0cql96hu	170	27	.	.	.
cord-281188-0cql96hu	171	1	As	as	IN
cord-281188-0cql96hu	171	2	mentioned	mention	VBN
cord-281188-0cql96hu	171	3	already	already	RB
cord-281188-0cql96hu	171	4	,	,	,
cord-281188-0cql96hu	171	5	shortage	shortage	NN
cord-281188-0cql96hu	171	6	in	in	IN
cord-281188-0cql96hu	171	7	key	key	JJ
cord-281188-0cql96hu	171	8	proteins	protein	NNS
cord-281188-0cql96hu	171	9	involved	involve	VBN
cord-281188-0cql96hu	171	10	in	in	IN
cord-281188-0cql96hu	171	11	the	the	DT
cord-281188-0cql96hu	171	12	cellular	cellular	JJ
cord-281188-0cql96hu	171	13	envelope	envelope	NN
cord-281188-0cql96hu	171	14	structure	structure	NN
cord-281188-0cql96hu	171	15	might	may	MD
cord-281188-0cql96hu	171	16	result	result	VB
cord-281188-0cql96hu	171	17	in	in	IN
cord-281188-0cql96hu	171	18	killing	killing	NN
cord-281188-0cql96hu	171	19	,	,	,
cord-281188-0cql96hu	171	20	but	but	CC
cord-281188-0cql96hu	171	21	the	the	DT
cord-281188-0cql96hu	171	22	association	association	NN
cord-281188-0cql96hu	171	23	with	with	IN
cord-281188-0cql96hu	171	24	the	the	DT
cord-281188-0cql96hu	171	25	quantity	quantity	NN
cord-281188-0cql96hu	171	26	of	of	IN
cord-281188-0cql96hu	171	27	these	these	DT
cord-281188-0cql96hu	171	28	proteins	protein	NNS
cord-281188-0cql96hu	171	29	,	,	,
cord-281188-0cql96hu	171	30	or	or	CC
cord-281188-0cql96hu	171	31	the	the	DT
cord-281188-0cql96hu	171	32	number	number	NN
cord-281188-0cql96hu	171	33	of	of	IN
cord-281188-0cql96hu	171	34	active	active	JJ
cord-281188-0cql96hu	171	35	ribosomes	ribosome	NNS
cord-281188-0cql96hu	171	36	,	,	,
cord-281188-0cql96hu	171	37	remains	remain	VBZ
cord-281188-0cql96hu	171	38	to	to	TO
cord-281188-0cql96hu	171	39	be	be	VB
cord-281188-0cql96hu	171	40	demonstrated	demonstrate	VBN
cord-281188-0cql96hu	171	41	.	.	.
cord-281188-0cql96hu	172	1	In	in	IN
cord-281188-0cql96hu	172	2	2007	2007	CD
cord-281188-0cql96hu	172	3	,	,	,
cord-281188-0cql96hu	172	4	a	a	DT
cord-281188-0cql96hu	172	5	then	then	RB
cord-281188-0cql96hu	172	6	graduate	graduate	JJ
cord-281188-0cql96hu	172	7	student	student	NN
cord-281188-0cql96hu	172	8	,	,	,
cord-281188-0cql96hu	172	9	Michael	Michael	NNP
cord-281188-0cql96hu	172	10	Kohanski	Kohanski	NNP
cord-281188-0cql96hu	172	11	,	,	,
cord-281188-0cql96hu	172	12	working	work	VBG
cord-281188-0cql96hu	172	13	with	with	IN
cord-281188-0cql96hu	172	14	James	James	NNP
cord-281188-0cql96hu	172	15	Collins	Collins	NNP
cord-281188-0cql96hu	172	16	,	,	,
cord-281188-0cql96hu	172	17	presented	present	VBD
cord-281188-0cql96hu	172	18	a	a	DT
cord-281188-0cql96hu	172	19	general	general	JJ
cord-281188-0cql96hu	172	20	hypothesis	hypothesis	NN
cord-281188-0cql96hu	172	21	for	for	IN
cord-281188-0cql96hu	172	22	how	how	WRB
cord-281188-0cql96hu	172	23	different	different	JJ
cord-281188-0cql96hu	172	24	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	172	25	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	172	26	kill	kill	VBP
cord-281188-0cql96hu	172	27	both	both	CC
cord-281188-0cql96hu	172	28	Gram	gram	NN
cord-281188-0cql96hu	172	29	-	-	HYPH
cord-281188-0cql96hu	172	30	positive	positive	JJ
cord-281188-0cql96hu	172	31	and	and	CC
cord-281188-0cql96hu	172	32	Gram	gram	NN
cord-281188-0cql96hu	172	33	-	-	HYPH
cord-281188-0cql96hu	172	34	negative	negative	JJ
cord-281188-0cql96hu	172	35	bacteria	bacteria	NNS
cord-281188-0cql96hu	172	36	and	and	CC
cord-281188-0cql96hu	172	37	evidence	evidence	NN
cord-281188-0cql96hu	172	38	in	in	IN
cord-281188-0cql96hu	172	39	support	support	NN
cord-281188-0cql96hu	172	40	of	of	IN
cord-281188-0cql96hu	172	41	that	that	DT
cord-281188-0cql96hu	172	42	hypothesis	hypothesis	NN
cord-281188-0cql96hu	172	43	.	.	.
cord-281188-0cql96hu	173	1	In	in	IN
cord-281188-0cql96hu	173	2	accord	accord	NN
cord-281188-0cql96hu	173	3	with	with	IN
cord-281188-0cql96hu	173	4	that	that	DT
cord-281188-0cql96hu	173	5	hypothesis	hypothesis	NN
cord-281188-0cql96hu	173	6	,	,	,
cord-281188-0cql96hu	173	7	these	these	DT
cord-281188-0cql96hu	173	8	drugs	drug	NNS
cord-281188-0cql96hu	173	9	stimulate	stimulate	VBP
cord-281188-0cql96hu	173	10	the	the	DT
cord-281188-0cql96hu	173	11	production	production	NN
cord-281188-0cql96hu	173	12	of	of	IN
cord-281188-0cql96hu	173	13	highly	highly	RB
cord-281188-0cql96hu	173	14	deleterious	deleterious	JJ
cord-281188-0cql96hu	173	15	hydroxyl	hydroxyl	NN
cord-281188-0cql96hu	173	16	radicals	radical	NNS
cord-281188-0cql96hu	173	17	,	,	,
cord-281188-0cql96hu	173	18	which	which	WDT
cord-281188-0cql96hu	173	19	kill	kill	VBP
cord-281188-0cql96hu	173	20	bacteria	bacteria	NNS
cord-281188-0cql96hu	173	21	by	by	IN
cord-281188-0cql96hu	173	22	oxidative	oxidative	JJ
cord-281188-0cql96hu	173	23	damage	damage	NN
cord-281188-0cql96hu	173	24	,	,	,
cord-281188-0cql96hu	173	25	inhibit	inhibit	VB
cord-281188-0cql96hu	173	26	the	the	DT
cord-281188-0cql96hu	173	27	tricarboxylic	tricarboxylic	JJ
cord-281188-0cql96hu	173	28	acid	acid	NN
cord-281188-0cql96hu	173	29	cycle	cycle	NN
cord-281188-0cql96hu	173	30	,	,	,
cord-281188-0cql96hu	173	31	transiently	transiently	RB
cord-281188-0cql96hu	173	32	deplete	deplete	VB
cord-281188-0cql96hu	173	33	NADH	NADH	NNP
cord-281188-0cql96hu	173	34	,	,	,
cord-281188-0cql96hu	173	35	destabilize	destabilize	VB
cord-281188-0cql96hu	173	36	iron	iron	NN
cord-281188-0cql96hu	173	37	-	-	HYPH
cord-281188-0cql96hu	173	38	sulfur	sulfur	NN
cord-281188-0cql96hu	173	39	clusters	cluster	NNS
cord-281188-0cql96hu	173	40	and	and	CC
cord-281188-0cql96hu	173	41	stimulate	stimulate	VB
cord-281188-0cql96hu	173	42	the	the	DT
cord-281188-0cql96hu	173	43	Fenton	Fenton	NNP
cord-281188-0cql96hu	173	44	reaction	reaction	NN
cord-281188-0cql96hu	173	45	,	,	,
cord-281188-0cql96hu	173	46	resulting	result	VBG
cord-281188-0cql96hu	173	47	in	in	IN
cord-281188-0cql96hu	173	48	lethal	lethal	JJ
cord-281188-0cql96hu	173	49	DNA	dna	NN
cord-281188-0cql96hu	173	50	breaks	break	VBZ
cord-281188-0cql96hu	173	51	86	86	CD
cord-281188-0cql96hu	173	52	.	.	.
cord-281188-0cql96hu	174	1	In	in	IN
cord-281188-0cql96hu	174	2	2013	2013	CD
cord-281188-0cql96hu	174	3	,	,	,
cord-281188-0cql96hu	174	4	a	a	DT
cord-281188-0cql96hu	174	5	series	series	NN
cord-281188-0cql96hu	174	6	of	of	IN
cord-281188-0cql96hu	174	7	articles	article	NNS
cord-281188-0cql96hu	174	8	were	be	VBD
cord-281188-0cql96hu	174	9	published	publish	VBN
cord-281188-0cql96hu	174	10	pointing	point	VBG
cord-281188-0cql96hu	174	11	out	out	RP
cord-281188-0cql96hu	174	12	the	the	DT
cord-281188-0cql96hu	174	13	limitations	limitation	NNS
cord-281188-0cql96hu	174	14	of	of	IN
cord-281188-0cql96hu	174	15	the	the	DT
cord-281188-0cql96hu	174	16	experiments	experiment	NNS
cord-281188-0cql96hu	174	17	on	on	IN
cord-281188-0cql96hu	174	18	which	which	WDT
cord-281188-0cql96hu	174	19	Kohanski	Kohanski	NNP
cord-281188-0cql96hu	174	20	and	and	CC
cord-281188-0cql96hu	174	21	colleagues	colleague	NNS
cord-281188-0cql96hu	174	22	32	32	CD
cord-281188-0cql96hu	174	23	based	base	VBD
cord-281188-0cql96hu	174	24	their	-PRON-	PRP$
cord-281188-0cql96hu	174	25	hypothesis	hypothesis	NN
cord-281188-0cql96hu	174	26	that	that	IN
cord-281188-0cql96hu	174	27	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	174	28	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	174	29	work	work	VBP
cord-281188-0cql96hu	174	30	through	through	IN
cord-281188-0cql96hu	174	31	a	a	DT
cord-281188-0cql96hu	174	32	common	common	JJ
cord-281188-0cql96hu	174	33	cell	cell	NN
cord-281188-0cql96hu	174	34	death	death	NN
cord-281188-0cql96hu	174	35	mechanism	mechanism	NN
cord-281188-0cql96hu	174	36	involving	involve	VBG
cord-281188-0cql96hu	174	37	ROS	ROS	NNP
cord-281188-0cql96hu	174	38	[	[	-LRB-
cord-281188-0cql96hu	174	39	87	87	CD
cord-281188-0cql96hu	174	40	]	]	-RRB-
cord-281188-0cql96hu	175	1	[	[	-LRB-
cord-281188-0cql96hu	175	2	88	88	CD
cord-281188-0cql96hu	175	3	]	]	-RRB-
cord-281188-0cql96hu	175	4	[	[	-LRB-
cord-281188-0cql96hu	175	5	89	89	CD
cord-281188-0cql96hu	175	6	]	]	-RRB-
cord-281188-0cql96hu	175	7	.	.	.
cord-281188-0cql96hu	176	1	These	these	DT
cord-281188-0cql96hu	176	2	authors	author	NNS
cord-281188-0cql96hu	176	3	did	do	VBD
cord-281188-0cql96hu	176	4	not	not	RB
cord-281188-0cql96hu	176	5	present	present	VB
cord-281188-0cql96hu	176	6	alternative	alternative	JJ
cord-281188-0cql96hu	176	7	mechanisms	mechanism	NNS
cord-281188-0cql96hu	176	8	for	for	IN
cord-281188-0cql96hu	176	9	the	the	DT
cord-281188-0cql96hu	176	10	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	176	11	activity	activity	NN
cord-281188-0cql96hu	176	12	of	of	IN
cord-281188-0cql96hu	176	13	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	176	14	.	.	.
cord-281188-0cql96hu	177	1	This	this	DT
cord-281188-0cql96hu	177	2	is	be	VBZ
cord-281188-0cql96hu	177	3	not	not	RB
cord-281188-0cql96hu	177	4	a	a	DT
cord-281188-0cql96hu	177	5	forum	forum	NN
cord-281188-0cql96hu	177	6	to	to	TO
cord-281188-0cql96hu	177	7	rant	rant	VB
cord-281188-0cql96hu	177	8	on	on	IN
cord-281188-0cql96hu	177	9	about	about	IN
cord-281188-0cql96hu	177	10	the	the	DT
cord-281188-0cql96hu	177	11	details	detail	NNS
cord-281188-0cql96hu	177	12	of	of	IN
cord-281188-0cql96hu	177	13	the	the	DT
cord-281188-0cql96hu	177	14	experiments	experiment	NNS
cord-281188-0cql96hu	177	15	performed	perform	VBN
cord-281188-0cql96hu	177	16	in	in	IN
cord-281188-0cql96hu	177	17	these	these	DT
cord-281188-0cql96hu	177	18	studies	study	NNS
cord-281188-0cql96hu	177	19	and	and	CC
cord-281188-0cql96hu	177	20	the	the	DT
cord-281188-0cql96hu	177	21	inferences	inference	NNS
cord-281188-0cql96hu	177	22	drawn	draw	VBN
cord-281188-0cql96hu	177	23	.	.	.
cord-281188-0cql96hu	178	1	It	-PRON-	PRP
cord-281188-0cql96hu	178	2	is	be	VBZ
cord-281188-0cql96hu	178	3	,	,	,
cord-281188-0cql96hu	178	4	however	however	RB
cord-281188-0cql96hu	178	5	,	,	,
cord-281188-0cql96hu	178	6	useful	useful	JJ
cord-281188-0cql96hu	178	7	to	to	TO
cord-281188-0cql96hu	178	8	consider	consider	VB
cord-281188-0cql96hu	178	9	what	what	WP
cord-281188-0cql96hu	178	10	came	come	VBD
cord-281188-0cql96hu	178	11	out	out	IN
cord-281188-0cql96hu	178	12	of	of	IN
cord-281188-0cql96hu	178	13	the	the	DT
cord-281188-0cql96hu	178	14	ROS	ROS	NNP
cord-281188-0cql96hu	178	15	'	'	POS
cord-281188-0cql96hu	178	16	debate	debate	NN
cord-281188-0cql96hu	178	17	'	'	''
cord-281188-0cql96hu	178	18	in	in	IN
cord-281188-0cql96hu	178	19	respect	respect	NN
cord-281188-0cql96hu	178	20	to	to	IN
cord-281188-0cql96hu	178	21	our	-PRON-	PRP$
cord-281188-0cql96hu	178	22	understanding	understanding	NN
cord-281188-0cql96hu	178	23	of	of	IN
cord-281188-0cql96hu	178	24	the	the	DT
cord-281188-0cql96hu	178	25	ultimate	ultimate	JJ
cord-281188-0cql96hu	178	26	mechanism	mechanism	NN
cord-281188-0cql96hu	178	27	responsible	responsible	JJ
cord-281188-0cql96hu	178	28	for	for	IN
cord-281188-0cql96hu	178	29	how	how	WRB
cord-281188-0cql96hu	178	30	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	178	31	kill	kill	VBP
cord-281188-0cql96hu	178	32	bacteria	bacteria	NNS
cord-281188-0cql96hu	178	33	.	.	.
cord-281188-0cql96hu	179	1	To	to	IN
cord-281188-0cql96hu	179	2	wit	wit	NN
cord-281188-0cql96hu	179	3	,	,	,
cord-281188-0cql96hu	179	4	the	the	DT
cord-281188-0cql96hu	179	5	debate	debate	NN
cord-281188-0cql96hu	179	6	is	be	VBZ
cord-281188-0cql96hu	179	7	a	a	DT
cord-281188-0cql96hu	179	8	compelling	compelling	JJ
cord-281188-0cql96hu	179	9	argument	argument	NN
cord-281188-0cql96hu	179	10	that	that	IN
cord-281188-0cql96hu	179	11	there	there	EX
cord-281188-0cql96hu	179	12	is	be	VBZ
cord-281188-0cql96hu	179	13	not	not	RB
cord-281188-0cql96hu	179	14	a	a	DT
cord-281188-0cql96hu	179	15	unique	unique	JJ
cord-281188-0cql96hu	179	16	mechanism	mechanism	NN
cord-281188-0cql96hu	179	17	by	by	IN
cord-281188-0cql96hu	179	18	which	which	WDT
cord-281188-0cql96hu	179	19	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	179	20	kill	kill	VBP
cord-281188-0cql96hu	179	21	bacteria	bacteria	NNS
cord-281188-0cql96hu	179	22	.	.	.
cord-281188-0cql96hu	180	1	In	in	IN
cord-281188-0cql96hu	180	2	the	the	DT
cord-281188-0cql96hu	180	3	years	year	NNS
cord-281188-0cql96hu	180	4	since	since	IN
cord-281188-0cql96hu	180	5	the	the	DT
cord-281188-0cql96hu	180	6	publication	publication	NN
cord-281188-0cql96hu	180	7	of	of	IN
cord-281188-0cql96hu	180	8	the	the	DT
cord-281188-0cql96hu	180	9	article	article	NN
cord-281188-0cql96hu	180	10	by	by	IN
cord-281188-0cql96hu	180	11	Kohanski	Kohanski	NNP
cord-281188-0cql96hu	180	12	and	and	CC
cord-281188-0cql96hu	180	13	colleagues	colleague	NNS
cord-281188-0cql96hu	180	14	32	32	CD
cord-281188-0cql96hu	180	15	,	,	,
cord-281188-0cql96hu	180	16	there	there	EX
cord-281188-0cql96hu	180	17	have	have	VBP
cord-281188-0cql96hu	180	18	been	be	VBN
cord-281188-0cql96hu	180	19	a	a	DT
cord-281188-0cql96hu	180	20	number	number	NN
cord-281188-0cql96hu	180	21	of	of	IN
cord-281188-0cql96hu	180	22	studies	study	NNS
cord-281188-0cql96hu	180	23	confirming	confirm	VBG
cord-281188-0cql96hu	180	24	that	that	IN
cord-281188-0cql96hu	180	25	ROS	ROS	NNP
cord-281188-0cql96hu	180	26	have	have	VB
cord-281188-0cql96hu	180	27	an	an	DT
cord-281188-0cql96hu	180	28	important	important	JJ
cord-281188-0cql96hu	180	29	role	role	NN
cord-281188-0cql96hu	180	30	in	in	IN
cord-281188-0cql96hu	180	31	antibiotic	antibiotic	RB
cord-281188-0cql96hu	180	32	-	-	HYPH
cord-281188-0cql96hu	180	33	mediated	mediate	VBN
cord-281188-0cql96hu	180	34	killing	killing	NN
cord-281188-0cql96hu	180	35	of	of	IN
cord-281188-0cql96hu	180	36	bacteria	bacteria	NNS
cord-281188-0cql96hu	180	37	.	.	.
cord-281188-0cql96hu	181	1	These	these	DT
cord-281188-0cql96hu	181	2	studies	study	NNS
cord-281188-0cql96hu	181	3	present	present	VBP
cord-281188-0cql96hu	181	4	evidence	evidence	NN
cord-281188-0cql96hu	181	5	that	that	IN
cord-281188-0cql96hu	181	6	ROS	ROS	NNP
cord-281188-0cql96hu	181	7	are	be	VBP
cord-281188-0cql96hu	181	8	frequently	frequently	RB
cord-281188-0cql96hu	181	9	synergistic	synergistic	JJ
cord-281188-0cql96hu	181	10	in	in	IN
cord-281188-0cql96hu	181	11	the	the	DT
cord-281188-0cql96hu	181	12	killing	killing	NN
cord-281188-0cql96hu	181	13	process	process	NN
cord-281188-0cql96hu	181	14	with	with	IN
cord-281188-0cql96hu	181	15	the	the	DT
cord-281188-0cql96hu	181	16	damage	damage	NN
cord-281188-0cql96hu	181	17	directly	directly	RB
cord-281188-0cql96hu	181	18	caused	cause	VBN
cord-281188-0cql96hu	181	19	by	by	IN
cord-281188-0cql96hu	181	20	the	the	DT
cord-281188-0cql96hu	181	21	antibiotic	antibiotic	NN
cord-281188-0cql96hu	181	22	in	in	IN
cord-281188-0cql96hu	181	23	the	the	DT
cord-281188-0cql96hu	181	24	primary	primary	JJ
cord-281188-0cql96hu	181	25	target	target	NN
cord-281188-0cql96hu	181	26	,	,	,
cord-281188-0cql96hu	181	27	and	and	CC
cord-281188-0cql96hu	181	28	dependent	dependent	JJ
cord-281188-0cql96hu	181	29	on	on	IN
cord-281188-0cql96hu	181	30	the	the	DT
cord-281188-0cql96hu	181	31	background	background	NN
cord-281188-0cql96hu	181	32	state	state	NN
cord-281188-0cql96hu	181	33	of	of	IN
cord-281188-0cql96hu	181	34	cells	cell	NNS
cord-281188-0cql96hu	181	35	already	already	RB
cord-281188-0cql96hu	181	36	stressed	stress	VBN
cord-281188-0cql96hu	181	37	by	by	IN
cord-281188-0cql96hu	181	38	the	the	DT
cord-281188-0cql96hu	181	39	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	181	40	90	90	CD
cord-281188-0cql96hu	181	41	,	,	,
cord-281188-0cql96hu	181	42	91	91	CD
cord-281188-0cql96hu	182	1	As	as	IN
cord-281188-0cql96hu	182	2	suggested	suggest	VBN
cord-281188-0cql96hu	182	3	by	by	IN
cord-281188-0cql96hu	182	4	Yang	Yang	NNP
cord-281188-0cql96hu	182	5	and	and	CC
cord-281188-0cql96hu	182	6	colleagues	colleague	NNS
cord-281188-0cql96hu	182	7	47	47	CD
cord-281188-0cql96hu	182	8	,	,	,
cord-281188-0cql96hu	182	9	this	this	DT
cord-281188-0cql96hu	182	10	killing	killing	NN
cord-281188-0cql96hu	182	11	is	be	VBZ
cord-281188-0cql96hu	182	12	not	not	RB
cord-281188-0cql96hu	182	13	simply	simply	RB
cord-281188-0cql96hu	182	14	a	a	DT
cord-281188-0cql96hu	182	15	matter	matter	NN
cord-281188-0cql96hu	182	16	of	of	IN
cord-281188-0cql96hu	182	17	how	how	WRB
cord-281188-0cql96hu	182	18	the	the	DT
cord-281188-0cql96hu	182	19	drugs	drug	NNS
cord-281188-0cql96hu	182	20	act	act	VBP
cord-281188-0cql96hu	182	21	on	on	IN
cord-281188-0cql96hu	182	22	their	-PRON-	PRP$
cord-281188-0cql96hu	182	23	targets	target	NNS
cord-281188-0cql96hu	182	24	but	but	CC
cord-281188-0cql96hu	182	25	is	be	VBZ
cord-281188-0cql96hu	182	26	rather	rather	RB
cord-281188-0cql96hu	182	27	the	the	DT
cord-281188-0cql96hu	182	28	result	result	NN
cord-281188-0cql96hu	182	29	of	of	IN
cord-281188-0cql96hu	182	30	an	an	DT
cord-281188-0cql96hu	182	31	array	array	NN
cord-281188-0cql96hu	182	32	of	of	IN
cord-281188-0cql96hu	182	33	downstream	downstream	JJ
cord-281188-0cql96hu	182	34	consequences	consequence	NNS
cord-281188-0cql96hu	182	35	of	of	IN
cord-281188-0cql96hu	182	36	the	the	DT
cord-281188-0cql96hu	182	37	effects	effect	NNS
cord-281188-0cql96hu	182	38	of	of	IN
cord-281188-0cql96hu	182	39	the	the	DT
cord-281188-0cql96hu	182	40	drug	drug	NN
cord-281188-0cql96hu	182	41	on	on	IN
cord-281188-0cql96hu	182	42	that	that	DT
cord-281188-0cql96hu	182	43	target	target	NN
cord-281188-0cql96hu	182	44	.	.	.
cord-281188-0cql96hu	183	1	As	as	IN
cord-281188-0cql96hu	183	2	indicated	indicate	VBN
cord-281188-0cql96hu	183	3	in	in	IN
cord-281188-0cql96hu	183	4	a	a	DT
cord-281188-0cql96hu	183	5	recent	recent	JJ
cord-281188-0cql96hu	183	6	study	study	NN
cord-281188-0cql96hu	183	7	by	by	IN
cord-281188-0cql96hu	183	8	Hong	Hong	NNP
cord-281188-0cql96hu	183	9	and	and	CC
cord-281188-0cql96hu	183	10	colleagues	colleague	NNS
cord-281188-0cql96hu	183	11	34	34	CD
cord-281188-0cql96hu	183	12	,	,	,
cord-281188-0cql96hu	183	13	ROS	ROS	NNP
cord-281188-0cql96hu	183	14	do	do	VBP
cord-281188-0cql96hu	183	15	indeed	indeed	RB
cord-281188-0cql96hu	183	16	have	have	VB
cord-281188-0cql96hu	183	17	a	a	DT
cord-281188-0cql96hu	183	18	role	role	NN
cord-281188-0cql96hu	183	19	in	in	IN
cord-281188-0cql96hu	183	20	those	those	DT
cord-281188-0cql96hu	183	21	downstream	downstream	JJ
cord-281188-0cql96hu	183	22	processes	process	NNS
cord-281188-0cql96hu	183	23	.	.	.
cord-281188-0cql96hu	184	1	In	in	IN
cord-281188-0cql96hu	184	2	the	the	DT
cord-281188-0cql96hu	184	3	following	following	JJ
cord-281188-0cql96hu	184	4	sections	section	NNS
cord-281188-0cql96hu	184	5	,	,	,
cord-281188-0cql96hu	184	6	we	-PRON-	PRP
cord-281188-0cql96hu	184	7	separately	separately	RB
cord-281188-0cql96hu	184	8	consider	consider	VBP
cord-281188-0cql96hu	184	9	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	184	10	of	of	IN
cord-281188-0cql96hu	184	11	six	six	CD
cord-281188-0cql96hu	184	12	classes	class	NNS
cord-281188-0cql96hu	184	13	,	,	,
cord-281188-0cql96hu	184	14	what	what	WP
cord-281188-0cql96hu	184	15	is	be	VBZ
cord-281188-0cql96hu	184	16	known	know	VBN
cord-281188-0cql96hu	184	17	,	,	,
cord-281188-0cql96hu	184	18	what	what	WP
cord-281188-0cql96hu	184	19	has	have	VBZ
cord-281188-0cql96hu	184	20	been	be	VBN
cord-281188-0cql96hu	184	21	postulated	postulate	VBN
cord-281188-0cql96hu	184	22	and	and	CC
cord-281188-0cql96hu	184	23	what	what	WP
cord-281188-0cql96hu	184	24	should	should	MD
cord-281188-0cql96hu	184	25	be	be	VB
cord-281188-0cql96hu	184	26	known	know	VBN
cord-281188-0cql96hu	184	27	about	about	IN
cord-281188-0cql96hu	184	28	the	the	DT
cord-281188-0cql96hu	184	29	ultimate	ultimate	JJ
cord-281188-0cql96hu	184	30	mechanisms	mechanism	NNS
cord-281188-0cql96hu	184	31	by	by	IN
cord-281188-0cql96hu	184	32	which	which	WDT
cord-281188-0cql96hu	184	33	they	-PRON-	PRP
cord-281188-0cql96hu	184	34	kill	kill	VBP
cord-281188-0cql96hu	184	35	bacteria	bacteria	NNS
cord-281188-0cql96hu	184	36	.	.	.
cord-281188-0cql96hu	185	1	See	see	VB
cord-281188-0cql96hu	185	2	fig	fig	NN
cord-281188-0cql96hu	185	3	.	.	.
cord-281188-0cql96hu	186	1	3	3	CD
cord-281188-0cql96hu	186	2	for	for	IN
cord-281188-0cql96hu	186	3	a	a	DT
cord-281188-0cql96hu	186	4	graphic	graphic	JJ
cord-281188-0cql96hu	186	5	summary	summary	NN
cord-281188-0cql96hu	186	6	of	of	IN
cord-281188-0cql96hu	186	7	what	what	WP
cord-281188-0cql96hu	186	8	follows	follow	VBZ
cord-281188-0cql96hu	186	9	.	.	.
cord-281188-0cql96hu	187	1	Aminoglycosides	Aminoglycosides	NNP
cord-281188-0cql96hu	187	2	.	.	.
cord-281188-0cql96hu	188	1	The	the	DT
cord-281188-0cql96hu	188	2	confidence	confidence	NN
cord-281188-0cql96hu	188	3	of	of	IN
cord-281188-0cql96hu	188	4	clinicians	clinician	NNS
cord-281188-0cql96hu	188	5	in	in	IN
cord-281188-0cql96hu	188	6	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	188	7	therapy	therapy	NN
cord-281188-0cql96hu	188	8	is	be	VBZ
cord-281188-0cql96hu	188	9	commonly	commonly	RB
cord-281188-0cql96hu	188	10	based	base	VBN
cord-281188-0cql96hu	188	11	on	on	IN
cord-281188-0cql96hu	188	12	the	the	DT
cord-281188-0cql96hu	188	13	known	known	JJ
cord-281188-0cql96hu	188	14	strong	strong	JJ
cord-281188-0cql96hu	188	15	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	188	16	effect	effect	NN
cord-281188-0cql96hu	188	17	of	of	IN
cord-281188-0cql96hu	188	18	these	these	DT
cord-281188-0cql96hu	188	19	drugs	drug	NNS
cord-281188-0cql96hu	188	20	.	.	.
cord-281188-0cql96hu	189	1	Although	although	IN
cord-281188-0cql96hu	189	2	a	a	DT
cord-281188-0cql96hu	189	3	great	great	JJ
cord-281188-0cql96hu	189	4	deal	deal	NN
cord-281188-0cql96hu	189	5	is	be	VBZ
cord-281188-0cql96hu	189	6	known	know	VBN
cord-281188-0cql96hu	189	7	about	about	IN
cord-281188-0cql96hu	189	8	the	the	DT
cord-281188-0cql96hu	189	9	proximal	proximal	JJ
cord-281188-0cql96hu	189	10	mechanism	mechanism	NN
cord-281188-0cql96hu	189	11	of	of	IN
cord-281188-0cql96hu	189	12	action	action	NN
cord-281188-0cql96hu	189	13	of	of	IN
cord-281188-0cql96hu	189	14	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	189	15	92,93	92,93	CD
cord-281188-0cql96hu	189	16	,	,	,
cord-281188-0cql96hu	189	17	no	no	DT
cord-281188-0cql96hu	189	18	widely	widely	RB
cord-281188-0cql96hu	189	19	accepted	accept	VBN
cord-281188-0cql96hu	189	20	or	or	CC
cord-281188-0cql96hu	189	21	supported	support	VBN
cord-281188-0cql96hu	189	22	hypothesis	hypothesis	NN
cord-281188-0cql96hu	189	23	exists	exist	VBZ
cord-281188-0cql96hu	189	24	so	so	RB
cord-281188-0cql96hu	189	25	far	far	RB
cord-281188-0cql96hu	189	26	for	for	IN
cord-281188-0cql96hu	189	27	the	the	DT
cord-281188-0cql96hu	189	28	ultimate	ultimate	JJ
cord-281188-0cql96hu	189	29	mechanism	mechanism	NN
cord-281188-0cql96hu	189	30	by	by	IN
cord-281188-0cql96hu	189	31	which	which	WDT
cord-281188-0cql96hu	189	32	these	these	DT
cord-281188-0cql96hu	189	33	drugs	drug	NNS
cord-281188-0cql96hu	189	34	kill	kill	VBP
cord-281188-0cql96hu	189	35	bacteria	bacteria	NNS
cord-281188-0cql96hu	189	36	.	.	.
cord-281188-0cql96hu	190	1	Three	three	CD
cord-281188-0cql96hu	190	2	not	not	RB
cord-281188-0cql96hu	190	3	mutually	mutually	RB
cord-281188-0cql96hu	190	4	exclusive	exclusive	JJ
cord-281188-0cql96hu	190	5	hypotheses	hypothesis	NNS
cord-281188-0cql96hu	190	6	stand	stand	VBP
cord-281188-0cql96hu	190	7	out	out	RP
cord-281188-0cql96hu	190	8	.	.	.
cord-281188-0cql96hu	191	1	A	a	DT
cord-281188-0cql96hu	191	2	fourth	fourth	JJ
cord-281188-0cql96hu	191	3	hypothesis	hypothesis	NN
cord-281188-0cql96hu	191	4	,	,	,
cord-281188-0cql96hu	191	5	death	death	NN
cord-281188-0cql96hu	191	6	by	by	IN
cord-281188-0cql96hu	191	7	superoxides	superoxides	NNP
cord-281188-0cql96hu	191	8	,	,	,
cord-281188-0cql96hu	191	9	applies	apply	VBZ
cord-281188-0cql96hu	191	10	to	to	IN
cord-281188-0cql96hu	191	11	all	all	DT
cord-281188-0cql96hu	191	12	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	191	13	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	191	14	and	and	CC
cord-281188-0cql96hu	191	15	will	will	MD
cord-281188-0cql96hu	191	16	be	be	VB
cord-281188-0cql96hu	191	17	considered	consider	VBN
cord-281188-0cql96hu	191	18	separately	separately	RB
cord-281188-0cql96hu	191	19	.	.	.
cord-281188-0cql96hu	192	1	The	the	DT
cord-281188-0cql96hu	192	2	most	most	RBS
cord-281188-0cql96hu	192	3	commonly	commonly	RB
cord-281188-0cql96hu	192	4	offered	offer	VBN
cord-281188-0cql96hu	192	5	explanation	explanation	NN
cord-281188-0cql96hu	192	6	for	for	IN
cord-281188-0cql96hu	192	7	the	the	DT
cord-281188-0cql96hu	192	8	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	192	9	action	action	NN
cord-281188-0cql96hu	192	10	of	of	IN
cord-281188-0cql96hu	192	11	this	this	DT
cord-281188-0cql96hu	192	12	class	class	NN
cord-281188-0cql96hu	192	13	of	of	IN
cord-281188-0cql96hu	192	14	drugs	drug	NNS
cord-281188-0cql96hu	192	15	is	be	VBZ
cord-281188-0cql96hu	192	16	that	that	IN
cord-281188-0cql96hu	192	17	the	the	DT
cord-281188-0cql96hu	192	18	ribosome	ribosome	NN
cord-281188-0cql96hu	192	19	-	-	HYPH
cord-281188-0cql96hu	192	20	aminoglycoside	aminoglycoside	NN
cord-281188-0cql96hu	192	21	interactions	interaction	NNS
cord-281188-0cql96hu	192	22	,	,	,
cord-281188-0cql96hu	192	23	mediated	mediate	VBN
cord-281188-0cql96hu	192	24	by	by	IN
cord-281188-0cql96hu	192	25	the	the	DT
cord-281188-0cql96hu	192	26	number	number	NN
cord-281188-0cql96hu	192	27	and	and	CC
cord-281188-0cql96hu	192	28	basicity	basicity	NN
cord-281188-0cql96hu	192	29	of	of	IN
cord-281188-0cql96hu	192	30	amino	amino	NN
cord-281188-0cql96hu	192	31	groups	group	NNS
cord-281188-0cql96hu	192	32	in	in	IN
cord-281188-0cql96hu	192	33	the	the	DT
cord-281188-0cql96hu	192	34	drug	drug	NN
cord-281188-0cql96hu	192	35	,	,	,
cord-281188-0cql96hu	192	36	give	give	VBP
cord-281188-0cql96hu	192	37	rise	rise	NN
cord-281188-0cql96hu	192	38	to	to	IN
cord-281188-0cql96hu	192	39	toxic	toxic	JJ
cord-281188-0cql96hu	192	40	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	192	41	proteins	protein	NNS
cord-281188-0cql96hu	192	42	,	,	,
cord-281188-0cql96hu	192	43	which	which	WDT
cord-281188-0cql96hu	192	44	kill	kill	VBP
cord-281188-0cql96hu	192	45	by	by	IN
cord-281188-0cql96hu	192	46	increasing	increase	VBG
cord-281188-0cql96hu	192	47	the	the	DT
cord-281188-0cql96hu	192	48	permeability	permeability	NN
cord-281188-0cql96hu	192	49	of	of	IN
cord-281188-0cql96hu	192	50	the	the	DT
cord-281188-0cql96hu	192	51	cell	cell	NN
cord-281188-0cql96hu	192	52	membrane	membrane	NN
cord-281188-0cql96hu	192	53	94	94	CD
cord-281188-0cql96hu	192	54	.	.	.
cord-281188-0cql96hu	193	1	However	however	RB
cord-281188-0cql96hu	193	2	,	,	,
cord-281188-0cql96hu	193	3	to	to	IN
cord-281188-0cql96hu	193	4	our	-PRON-	PRP$
cord-281188-0cql96hu	193	5	knowledge	knowledge	NN
cord-281188-0cql96hu	193	6	,	,	,
cord-281188-0cql96hu	193	7	these	these	DT
cord-281188-0cql96hu	193	8	toxic	toxic	JJ
cord-281188-0cql96hu	193	9	proteins	protein	NNS
cord-281188-0cql96hu	193	10	have	have	VBP
cord-281188-0cql96hu	193	11	not	not	RB
cord-281188-0cql96hu	193	12	been	be	VBN
cord-281188-0cql96hu	193	13	isolated	isolate	VBN
cord-281188-0cql96hu	193	14	,	,	,
cord-281188-0cql96hu	193	15	and	and	CC
cord-281188-0cql96hu	193	16	how	how	WRB
cord-281188-0cql96hu	193	17	they	-PRON-	PRP
cord-281188-0cql96hu	193	18	actually	actually	RB
cord-281188-0cql96hu	193	19	kill	kill	VBP
cord-281188-0cql96hu	193	20	remains	remain	VBZ
cord-281188-0cql96hu	193	21	undemonstrated	undemonstrated	JJ
cord-281188-0cql96hu	193	22	.	.	.
cord-281188-0cql96hu	194	1	It	-PRON-	PRP
cord-281188-0cql96hu	194	2	is	be	VBZ
cord-281188-0cql96hu	194	3	also	also	RB
cord-281188-0cql96hu	194	4	unclear	unclear	JJ
cord-281188-0cql96hu	194	5	why	why	WRB
cord-281188-0cql96hu	194	6	these	these	DT
cord-281188-0cql96hu	194	7	postulated	postulate	VBN
cord-281188-0cql96hu	194	8	products	product	NNS
cord-281188-0cql96hu	194	9	of	of	IN
cord-281188-0cql96hu	194	10	mistranslation	mistranslation	NN
cord-281188-0cql96hu	194	11	are	be	VBP
cord-281188-0cql96hu	194	12	not	not	RB
cord-281188-0cql96hu	194	13	destroyed	destroy	VBN
cord-281188-0cql96hu	194	14	by	by	IN
cord-281188-0cql96hu	194	15	the	the	DT
cord-281188-0cql96hu	194	16	proteases	protease	NNS
cord-281188-0cql96hu	194	17	that	that	WDT
cord-281188-0cql96hu	194	18	usually	usually	RB
cord-281188-0cql96hu	194	19	remove	remove	VBP
cord-281188-0cql96hu	194	20	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	194	21	and	and	CC
cord-281188-0cql96hu	194	22	misfolded	misfolde	VBN
cord-281188-0cql96hu	194	23	proteins	protein	NNS
cord-281188-0cql96hu	194	24	.	.	.
cord-281188-0cql96hu	195	1	On	on	IN
cord-281188-0cql96hu	195	2	the	the	DT
cord-281188-0cql96hu	195	3	other	other	JJ
cord-281188-0cql96hu	195	4	hand	hand	NN
cord-281188-0cql96hu	195	5	,	,	,
cord-281188-0cql96hu	195	6	in	in	IN
cord-281188-0cql96hu	195	7	opposition	opposition	NN
cord-281188-0cql96hu	195	8	of	of	IN
cord-281188-0cql96hu	195	9	the	the	DT
cord-281188-0cql96hu	195	10	toxic	toxic	JJ
cord-281188-0cql96hu	195	11	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	195	12	protein	protein	NN
cord-281188-0cql96hu	195	13	hypothesis	hypothesis	NN
cord-281188-0cql96hu	195	14	as	as	IN
cord-281188-0cql96hu	195	15	the	the	DT
cord-281188-0cql96hu	195	16	unique	unique	JJ
cord-281188-0cql96hu	195	17	mechanism	mechanism	NN
cord-281188-0cql96hu	195	18	of	of	IN
cord-281188-0cql96hu	195	19	killing	kill	VBG
cord-281188-0cql96hu	195	20	by	by	IN
cord-281188-0cql96hu	195	21	these	these	DT
cord-281188-0cql96hu	195	22	drugs	drug	NNS
cord-281188-0cql96hu	195	23	is	be	VBZ
cord-281188-0cql96hu	195	24	the	the	DT
cord-281188-0cql96hu	195	25	observation	observation	NN
cord-281188-0cql96hu	195	26	that	that	IN
cord-281188-0cql96hu	195	27	killing	killing	NN
cord-281188-0cql96hu	195	28	occurs	occur	VBZ
cord-281188-0cql96hu	195	29	in	in	IN
cord-281188-0cql96hu	195	30	the	the	DT
cord-281188-0cql96hu	195	31	absence	absence	NN
cord-281188-0cql96hu	195	32	of	of	IN
cord-281188-0cql96hu	195	33	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	195	34	-	-	HYPH
cord-281188-0cql96hu	195	35	ribosome	ribosome	NN
cord-281188-0cql96hu	195	36	binding	binding	NN
cord-281188-0cql96hu	195	37	,	,	,
cord-281188-0cql96hu	195	38	as	as	IN
cord-281188-0cql96hu	195	39	happens	happen	VBZ
cord-281188-0cql96hu	195	40	with	with	IN
cord-281188-0cql96hu	195	41	gentamicin	gentamicin	NNS
cord-281188-0cql96hu	195	42	in	in	IN
cord-281188-0cql96hu	195	43	ribosomal	ribosomal	JJ
cord-281188-0cql96hu	195	44	1041A	1041a	CD
cord-281188-0cql96hu	196	1	>	>	XX
cord-281188-0cql96hu	196	2	G	g	NN
cord-281188-0cql96hu	196	3	mutants	mutant	NNS
cord-281188-0cql96hu	196	4	that	that	WDT
cord-281188-0cql96hu	196	5	have	have	VBP
cord-281188-0cql96hu	196	6	a	a	DT
cord-281188-0cql96hu	196	7	single	single	JJ
cord-281188-0cql96hu	196	8	rrn	rrn	NN
cord-281188-0cql96hu	196	9	operon	operon	NN
cord-281188-0cql96hu	196	10	95	95	CD
cord-281188-0cql96hu	197	1	(	(	-LRB-
cord-281188-0cql96hu	197	2	B.R.L.	B.R.L.	NNP
cord-281188-0cql96hu	197	3	and	and	CC
cord-281188-0cql96hu	197	4	F.B.	F.B.	NNP
cord-281188-0cql96hu	197	5	,	,	,
cord-281188-0cql96hu	197	6	unpublished	unpublished	JJ
cord-281188-0cql96hu	197	7	observations	observation	NNS
cord-281188-0cql96hu	197	8	)	)	-RRB-
cord-281188-0cql96hu	197	9	and	and	CC
cord-281188-0cql96hu	197	10	in	in	IN
cord-281188-0cql96hu	197	11	the	the	DT
cord-281188-0cql96hu	197	12	presence	presence	NN
cord-281188-0cql96hu	197	13	of	of	IN
cord-281188-0cql96hu	197	14	the	the	DT
cord-281188-0cql96hu	197	15	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	197	16	resistance	resistance	NN
cord-281188-0cql96hu	197	17	gene	gene	NN
cord-281188-0cql96hu	197	18	armA	armA	NNP
cord-281188-0cql96hu	197	19	,	,	,
cord-281188-0cql96hu	197	20	encoding	encode	VBG
cord-281188-0cql96hu	197	21	a	a	DT
cord-281188-0cql96hu	197	22	16S	16s	JJ
cord-281188-0cql96hu	197	23	ribosomal	ribosomal	NN
cord-281188-0cql96hu	197	24	RNA	RNA	NNP
cord-281188-0cql96hu	197	25	guanine	guanine	NN
cord-281188-0cql96hu	197	26	1405-N	1405-n	CD
cord-281188-0cql96hu	197	27	7	7	CD
cord-281188-0cql96hu	197	28	-methyltransferase	-methyltransferase	SYM
cord-281188-0cql96hu	197	29	96	96	CD
cord-281188-0cql96hu	197	30	.	.	.
cord-281188-0cql96hu	198	1	There	there	EX
cord-281188-0cql96hu	198	2	is	be	VBZ
cord-281188-0cql96hu	198	3	also	also	RB
cord-281188-0cql96hu	198	4	a	a	DT
cord-281188-0cql96hu	198	5	pharmacodynamic	pharmacodynamic	JJ
cord-281188-0cql96hu	198	6	observation	observation	NN
cord-281188-0cql96hu	198	7	consistent	consistent	JJ
cord-281188-0cql96hu	198	8	with	with	IN
cord-281188-0cql96hu	198	9	the	the	DT
cord-281188-0cql96hu	198	10	toxic	toxic	JJ
cord-281188-0cql96hu	198	11	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	198	12	protein	protein	NN
cord-281188-0cql96hu	198	13	hypothesis	hypothesis	NN
cord-281188-0cql96hu	198	14	.	.	.
cord-281188-0cql96hu	199	1	In	in	IN
cord-281188-0cql96hu	199	2	accord	accord	NN
cord-281188-0cql96hu	199	3	with	with	IN
cord-281188-0cql96hu	199	4	this	this	DT
cord-281188-0cql96hu	199	5	hypothesis	hypothesis	NN
cord-281188-0cql96hu	199	6	,	,	,
cord-281188-0cql96hu	199	7	the	the	DT
cord-281188-0cql96hu	199	8	rate	rate	NN
cord-281188-0cql96hu	199	9	of	of	IN
cord-281188-0cql96hu	199	10	ribosome	ribosome	NN
cord-281188-0cql96hu	199	11	binding	binding	NN
cord-281188-0cql96hu	199	12	,	,	,
cord-281188-0cql96hu	199	13	and	and	CC
cord-281188-0cql96hu	199	14	thereby	thereby	RB
cord-281188-0cql96hu	199	15	the	the	DT
cord-281188-0cql96hu	199	16	abundance	abundance	NN
cord-281188-0cql96hu	199	17	of	of	IN
cord-281188-0cql96hu	199	18	toxic	toxic	JJ
cord-281188-0cql96hu	199	19	proteins	protein	NNS
cord-281188-0cql96hu	199	20	generated	generate	VBN
cord-281188-0cql96hu	199	21	by	by	IN
cord-281188-0cql96hu	199	22	mistranslation	mistranslation	NN
cord-281188-0cql96hu	199	23	,	,	,
cord-281188-0cql96hu	199	24	should	should	MD
cord-281188-0cql96hu	199	25	be	be	VB
cord-281188-0cql96hu	199	26	proportional	proportional	JJ
cord-281188-0cql96hu	199	27	to	to	IN
cord-281188-0cql96hu	199	28	the	the	DT
cord-281188-0cql96hu	199	29	growth	growth	NN
cord-281188-0cql96hu	199	30	rate	rate	NN
cord-281188-0cql96hu	199	31	of	of	IN
cord-281188-0cql96hu	199	32	the	the	DT
cord-281188-0cql96hu	199	33	target	target	NN
cord-281188-0cql96hu	199	34	population	population	NN
cord-281188-0cql96hu	199	35	and	and	CC
cord-281188-0cql96hu	199	36	the	the	DT
cord-281188-0cql96hu	199	37	number	number	NN
cord-281188-0cql96hu	199	38	of	of	IN
cord-281188-0cql96hu	199	39	ribosomes	ribosome	NNS
cord-281188-0cql96hu	199	40	,	,	,
cord-281188-0cql96hu	199	41	which	which	WDT
cord-281188-0cql96hu	199	42	indeed	indeed	RB
cord-281188-0cql96hu	199	43	has	have	VBZ
cord-281188-0cql96hu	199	44	been	be	VBN
cord-281188-0cql96hu	199	45	observed	observe	VBN
cord-281188-0cql96hu	199	46	97	97	CD
cord-281188-0cql96hu	199	47	.	.	.
cord-281188-0cql96hu	200	1	However	however	RB
cord-281188-0cql96hu	200	2	,	,	,
cord-281188-0cql96hu	200	3	some	some	DT
cord-281188-0cql96hu	200	4	observations	observation	NNS
cord-281188-0cql96hu	200	5	question	question	VBP
cord-281188-0cql96hu	200	6	the	the	DT
cord-281188-0cql96hu	200	7	uniqueness	uniqueness	NN
cord-281188-0cql96hu	200	8	of	of	IN
cord-281188-0cql96hu	200	9	the	the	DT
cord-281188-0cql96hu	200	10	toxic	toxic	JJ
cord-281188-0cql96hu	200	11	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	200	12	protein	protein	NN
cord-281188-0cql96hu	200	13	mechanism	mechanism	NN
cord-281188-0cql96hu	200	14	explaining	explain	VBG
cord-281188-0cql96hu	200	15	the	the	DT
cord-281188-0cql96hu	200	16	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	200	17	effect	effect	NN
cord-281188-0cql96hu	200	18	of	of	IN
cord-281188-0cql96hu	200	19	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	200	20	.	.	.
cord-281188-0cql96hu	201	1	Most	most	RBS
cord-281188-0cql96hu	201	2	importantly	importantly	RB
cord-281188-0cql96hu	201	3	,	,	,
cord-281188-0cql96hu	201	4	gentamicin	gentamicin	NNS
cord-281188-0cql96hu	201	5	can	can	MD
cord-281188-0cql96hu	201	6	kill	kill	VB
cord-281188-0cql96hu	201	7	E.	E.	NNP
cord-281188-0cql96hu	201	8	coli	coli	NNS
cord-281188-0cql96hu	201	9	and	and	CC
cord-281188-0cql96hu	201	10	S.	S.	NNP
cord-281188-0cql96hu	201	11	aureus	aureus	NN
cord-281188-0cql96hu	201	12	in	in	IN
cord-281188-0cql96hu	201	13	the	the	DT
cord-281188-0cql96hu	201	14	stationary	stationary	JJ
cord-281188-0cql96hu	201	15	phase	phase	NN
cord-281188-0cql96hu	201	16	,	,	,
cord-281188-0cql96hu	201	17	when	when	WRB
cord-281188-0cql96hu	201	18	the	the	DT
cord-281188-0cql96hu	201	19	number	number	NN
cord-281188-0cql96hu	201	20	of	of	IN
cord-281188-0cql96hu	201	21	ribosomes	ribosome	NNS
cord-281188-0cql96hu	201	22	is	be	VBZ
cord-281188-0cql96hu	201	23	minimal	minimal	JJ
cord-281188-0cql96hu	201	24	35	35	CD
cord-281188-0cql96hu	201	25	,	,	,
cord-281188-0cql96hu	201	26	and	and	CC
cord-281188-0cql96hu	201	27	is	be	VBZ
cord-281188-0cql96hu	201	28	more	more	RBR
cord-281188-0cql96hu	201	29	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	201	30	in	in	IN
cord-281188-0cql96hu	201	31	E.	E.	NNP
cord-281188-0cql96hu	201	32	coli	coli	VBZ
cord-281188-0cql96hu	201	33	variants	variant	NNS
cord-281188-0cql96hu	201	34	with	with	IN
cord-281188-0cql96hu	201	35	a	a	DT
cord-281188-0cql96hu	201	36	reduced	reduce	VBN
cord-281188-0cql96hu	201	37	number	number	NN
cord-281188-0cql96hu	201	38	of	of	IN
cord-281188-0cql96hu	201	39	rrn	rrn	NN
cord-281188-0cql96hu	201	40	operons	operon	NNS
cord-281188-0cql96hu	201	41	3	3	CD
cord-281188-0cql96hu	201	42	.	.	.
cord-281188-0cql96hu	202	1	Collectively	collectively	RB
cord-281188-0cql96hu	202	2	,	,	,
cord-281188-0cql96hu	202	3	these	these	DT
cord-281188-0cql96hu	202	4	observations	observation	NNS
cord-281188-0cql96hu	202	5	suggest	suggest	VBP
cord-281188-0cql96hu	202	6	a	a	DT
cord-281188-0cql96hu	202	7	ribosome	ribosome	NN
cord-281188-0cql96hu	202	8	-	-	HYPH
cord-281188-0cql96hu	202	9	independent	independent	JJ
cord-281188-0cql96hu	202	10	(	(	-LRB-
cord-281188-0cql96hu	202	11	but	but	CC
cord-281188-0cql96hu	202	12	not	not	RB
cord-281188-0cql96hu	202	13	alternative	alternative	JJ
cord-281188-0cql96hu	202	14	)	)	-RRB-
cord-281188-0cql96hu	202	15	mechanism	mechanism	NN
cord-281188-0cql96hu	202	16	by	by	IN
cord-281188-0cql96hu	202	17	which	which	WDT
cord-281188-0cql96hu	202	18	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	202	19	kill	kill	VBP
cord-281188-0cql96hu	202	20	bacteria	bacteria	NNS
cord-281188-0cql96hu	202	21	.	.	.
cord-281188-0cql96hu	203	1	Ribosome	ribosome	NN
cord-281188-0cql96hu	203	2	-	-	HYPH
cord-281188-0cql96hu	203	3	independent	independent	JJ
cord-281188-0cql96hu	203	4	killing	killing	NN
cord-281188-0cql96hu	203	5	by	by	IN
cord-281188-0cql96hu	203	6	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	203	7	involves	involve	VBZ
cord-281188-0cql96hu	203	8	direct	direct	JJ
cord-281188-0cql96hu	203	9	killing	killing	NN
cord-281188-0cql96hu	203	10	by	by	IN
cord-281188-0cql96hu	203	11	'	'	``
cord-281188-0cql96hu	203	12	surface	surface	NN
cord-281188-0cql96hu	203	13	action	action	NN
cord-281188-0cql96hu	203	14	'	'	''
cord-281188-0cql96hu	203	15	.	.	.
cord-281188-0cql96hu	204	1	The	the	DT
cord-281188-0cql96hu	204	2	polycationic	polycationic	NNP
cord-281188-0cql96hu	204	3	aminoglycoside	aminoglycoside	NN
cord-281188-0cql96hu	204	4	molecules	molecule	NNS
cord-281188-0cql96hu	204	5	replace	replace	VBP
cord-281188-0cql96hu	204	6	Mg	Mg	NNP
cord-281188-0cql96hu	204	7	2	2	CD
cord-281188-0cql96hu	204	8	+	+	SYM
cord-281188-0cql96hu	204	9	cations	cation	NNS
cord-281188-0cql96hu	204	10	and	and	CC
cord-281188-0cql96hu	204	11	thus	thus	RB
cord-281188-0cql96hu	204	12	destabilize	destabilize	VB
cord-281188-0cql96hu	204	13	key	key	JJ
cord-281188-0cql96hu	204	14	lipid	lipid	NN
cord-281188-0cql96hu	204	15	structures	structure	NNS
cord-281188-0cql96hu	204	16	of	of	IN
cord-281188-0cql96hu	204	17	the	the	DT
cord-281188-0cql96hu	204	18	outer	outer	JJ
cord-281188-0cql96hu	204	19	membrane	membrane	NN
cord-281188-0cql96hu	204	20	92,98	92,98	CD
cord-281188-0cql96hu	204	21	-	-	SYM
cord-281188-0cql96hu	204	22	101	101	CD
cord-281188-0cql96hu	204	23	.	.	.
cord-281188-0cql96hu	205	1	After	after	IN
cord-281188-0cql96hu	205	2	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	205	3	exposure	exposure	NN
cord-281188-0cql96hu	205	4	,	,	,
cord-281188-0cql96hu	205	5	potassium	potassium	NN
cord-281188-0cql96hu	205	6	and	and	CC
cord-281188-0cql96hu	205	7	intracellular	intracellular	JJ
cord-281188-0cql96hu	205	8	molecules	molecule	NNS
cord-281188-0cql96hu	205	9	such	such	JJ
cord-281188-0cql96hu	205	10	as	as	IN
cord-281188-0cql96hu	205	11	nucleotides	nucleotide	NNS
cord-281188-0cql96hu	205	12	leak	leak	VBP
cord-281188-0cql96hu	205	13	from	from	IN
cord-281188-0cql96hu	205	14	the	the	DT
cord-281188-0cql96hu	205	15	bacterial	bacterial	JJ
cord-281188-0cql96hu	205	16	cell	cell	NN
cord-281188-0cql96hu	205	17	immediately	immediately	RB
cord-281188-0cql96hu	205	18	,	,	,
cord-281188-0cql96hu	205	19	certainly	certainly	RB
cord-281188-0cql96hu	205	20	no	no	RB
cord-281188-0cql96hu	205	21	later	later	RB
cord-281188-0cql96hu	205	22	than	than	IN
cord-281188-0cql96hu	205	23	protein	protein	NN
cord-281188-0cql96hu	205	24	synthesis	synthesis	NN
cord-281188-0cql96hu	205	25	inhibitory	inhibitory	JJ
cord-281188-0cql96hu	205	26	effects	effect	NNS
cord-281188-0cql96hu	205	27	35	35	CD
cord-281188-0cql96hu	205	28	,	,	,
cord-281188-0cql96hu	205	29	92	92	CD
cord-281188-0cql96hu	205	30	,	,	,
cord-281188-0cql96hu	205	31	102	102	CD
cord-281188-0cql96hu	205	32	.	.	.
cord-281188-0cql96hu	206	1	Besides	besides	RB
cord-281188-0cql96hu	206	2	,	,	,
cord-281188-0cql96hu	206	3	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	206	4	exposure	exposure	NN
cord-281188-0cql96hu	206	5	increases	increase	VBZ
cord-281188-0cql96hu	206	6	alarmone	alarmone	CD
cord-281188-0cql96hu	206	7	levels	level	NNS
cord-281188-0cql96hu	206	8	,	,	,
cord-281188-0cql96hu	206	9	resulting	result	VBG
cord-281188-0cql96hu	206	10	in	in	IN
cord-281188-0cql96hu	206	11	increased	increase	VBN
cord-281188-0cql96hu	206	12	membrane	membrane	NN
cord-281188-0cql96hu	206	13	damage	damage	NN
cord-281188-0cql96hu	206	14	103	103	CD
cord-281188-0cql96hu	207	1	As	as	IN
cord-281188-0cql96hu	207	2	stated	state	VBN
cord-281188-0cql96hu	207	3	before	before	RB
cord-281188-0cql96hu	207	4	,	,	,
cord-281188-0cql96hu	207	5	a	a	DT
cord-281188-0cql96hu	207	6	direct	direct	JJ
cord-281188-0cql96hu	207	7	effect	effect	NN
cord-281188-0cql96hu	207	8	of	of	IN
cord-281188-0cql96hu	207	9	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	207	10	on	on	IN
cord-281188-0cql96hu	207	11	the	the	DT
cord-281188-0cql96hu	207	12	bacterial	bacterial	JJ
cord-281188-0cql96hu	207	13	cell	cell	NN
cord-281188-0cql96hu	207	14	membrane	membrane	NN
cord-281188-0cql96hu	207	15	is	be	VBZ
cord-281188-0cql96hu	207	16	not	not	RB
cord-281188-0cql96hu	207	17	incompatible	incompatible	JJ
cord-281188-0cql96hu	207	18	with	with	IN
cord-281188-0cql96hu	207	19	the	the	DT
cord-281188-0cql96hu	207	20	need	need	NN
cord-281188-0cql96hu	207	21	for	for	IN
cord-281188-0cql96hu	207	22	ribosomal	ribosomal	JJ
cord-281188-0cql96hu	207	23	interaction	interaction	NN
cord-281188-0cql96hu	207	24	.	.	.
cord-281188-0cql96hu	208	1	Binding	bind	VBG
cord-281188-0cql96hu	208	2	to	to	IN
cord-281188-0cql96hu	208	3	the	the	DT
cord-281188-0cql96hu	208	4	ribosome	ribosome	NN
cord-281188-0cql96hu	208	5	triggers	trigger	VBZ
cord-281188-0cql96hu	208	6	a	a	DT
cord-281188-0cql96hu	208	7	massive	massive	JJ
cord-281188-0cql96hu	208	8	secondary	secondary	JJ
cord-281188-0cql96hu	208	9	,	,	,
cord-281188-0cql96hu	208	10	energy	energy	NN
cord-281188-0cql96hu	208	11	-	-	HYPH
cord-281188-0cql96hu	208	12	dependent	dependent	JJ
cord-281188-0cql96hu	208	13	uptake	uptake	NN
cord-281188-0cql96hu	208	14	of	of	IN
cord-281188-0cql96hu	208	15	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	208	16	104	104	CD
cord-281188-0cql96hu	208	17	.	.	.
cord-281188-0cql96hu	209	1	This	this	DT
cord-281188-0cql96hu	209	2	uptake	uptake	NN
cord-281188-0cql96hu	209	3	will	will	MD
cord-281188-0cql96hu	209	4	produce	produce	VB
cord-281188-0cql96hu	209	5	a	a	DT
cord-281188-0cql96hu	209	6	'	'	``
cord-281188-0cql96hu	209	7	cationic	cationic	JJ
cord-281188-0cql96hu	209	8	disturbance	disturbance	NN
cord-281188-0cql96hu	209	9	'	'	''
cord-281188-0cql96hu	209	10	of	of	IN
cord-281188-0cql96hu	209	11	the	the	DT
cord-281188-0cql96hu	209	12	membrane	membrane	NN
cord-281188-0cql96hu	209	13	integrity	integrity	NN
cord-281188-0cql96hu	209	14	and	and	CC
cord-281188-0cql96hu	209	15	thereby	thereby	RB
cord-281188-0cql96hu	209	16	kill	kill	VB
cord-281188-0cql96hu	209	17	without	without	IN
cord-281188-0cql96hu	209	18	further	further	JJ
cord-281188-0cql96hu	209	19	involvement	involvement	NN
cord-281188-0cql96hu	209	20	of	of	IN
cord-281188-0cql96hu	209	21	ribosomes	ribosome	NNS
cord-281188-0cql96hu	209	22	.	.	.
cord-281188-0cql96hu	210	1	The	the	DT
cord-281188-0cql96hu	210	2	quinolones	quinolone	NNS
cord-281188-0cql96hu	210	3	.	.	.
cord-281188-0cql96hu	211	1	Fluoroquinolones	fluoroquinolone	NNS
cord-281188-0cql96hu	211	2	bind	bind	VBP
cord-281188-0cql96hu	211	3	to	to	IN
cord-281188-0cql96hu	211	4	DNA	dna	NN
cord-281188-0cql96hu	211	5	gyrase	gyrase	NN
cord-281188-0cql96hu	211	6	and	and	CC
cord-281188-0cql96hu	211	7	topoisomerase	topoisomerase	NN
cord-281188-0cql96hu	211	8	IV	IV	NNP
cord-281188-0cql96hu	211	9	,	,	,
cord-281188-0cql96hu	211	10	leading	lead	VBG
cord-281188-0cql96hu	211	11	to	to	IN
cord-281188-0cql96hu	211	12	the	the	DT
cord-281188-0cql96hu	211	13	formation	formation	NN
cord-281188-0cql96hu	211	14	of	of	IN
cord-281188-0cql96hu	211	15	stable	stable	JJ
cord-281188-0cql96hu	211	16	drug	drug	NN
cord-281188-0cql96hu	211	17	-	-	HYPH
cord-281188-0cql96hu	211	18	enzyme	enzyme	NN
cord-281188-0cql96hu	211	19	-	-	HYPH
cord-281188-0cql96hu	211	20	DNA	dna	NN
cord-281188-0cql96hu	211	21	complexes	complex	NNS
cord-281188-0cql96hu	211	22	that	that	WDT
cord-281188-0cql96hu	211	23	block	block	VBP
cord-281188-0cql96hu	211	24	DNA	dna	NN
cord-281188-0cql96hu	211	25	replication	replication	NN
cord-281188-0cql96hu	211	26	and	and	CC
cord-281188-0cql96hu	211	27	result	result	VB
cord-281188-0cql96hu	211	28	in	in	IN
cord-281188-0cql96hu	211	29	DNA	dna	NN
cord-281188-0cql96hu	211	30	double	double	JJ
cord-281188-0cql96hu	211	31	-	-	HYPH
cord-281188-0cql96hu	211	32	strand	strand	NN
cord-281188-0cql96hu	211	33	breaks	break	NNS
cord-281188-0cql96hu	211	34	105	105	CD
cord-281188-0cql96hu	211	35	.	.	.
cord-281188-0cql96hu	212	1	Recombination	recombination	NN
cord-281188-0cql96hu	212	2	and	and	CC
cord-281188-0cql96hu	212	3	excision	excision	NN
cord-281188-0cql96hu	212	4	repair	repair	NN
cord-281188-0cql96hu	212	5	is	be	VBZ
cord-281188-0cql96hu	212	6	involved	involve	VBN
cord-281188-0cql96hu	212	7	in	in	IN
cord-281188-0cql96hu	212	8	the	the	DT
cord-281188-0cql96hu	212	9	repair	repair	NN
cord-281188-0cql96hu	212	10	of	of	IN
cord-281188-0cql96hu	212	11	quinolone	quinolone	NN
cord-281188-0cql96hu	212	12	-	-	HYPH
cord-281188-0cql96hu	212	13	damaged	damage	VBN
cord-281188-0cql96hu	212	14	DNA	dna	NN
cord-281188-0cql96hu	212	15	,	,	,
cord-281188-0cql96hu	212	16	but	but	CC
cord-281188-0cql96hu	212	17	continuous	continuous	JJ
cord-281188-0cql96hu	212	18	induction	induction	NN
cord-281188-0cql96hu	212	19	of	of	IN
cord-281188-0cql96hu	212	20	these	these	DT
cord-281188-0cql96hu	212	21	systems	system	NNS
cord-281188-0cql96hu	212	22	in	in	IN
cord-281188-0cql96hu	212	23	response	response	NN
cord-281188-0cql96hu	212	24	to	to	IN
cord-281188-0cql96hu	212	25	exposure	exposure	NN
cord-281188-0cql96hu	212	26	to	to	IN
cord-281188-0cql96hu	212	27	the	the	DT
cord-281188-0cql96hu	212	28	drug	drug	NN
cord-281188-0cql96hu	212	29	triggers	trigger	VBZ
cord-281188-0cql96hu	212	30	the	the	DT
cord-281188-0cql96hu	212	31	SOS	SOS	NNP
cord-281188-0cql96hu	212	32	response	response	NN
cord-281188-0cql96hu	212	33	31	31	CD
cord-281188-0cql96hu	212	34	,	,	,
cord-281188-0cql96hu	212	35	106	106	CD
cord-281188-0cql96hu	212	36	.	.	.
cord-281188-0cql96hu	213	1	Initially	initially	RB
cord-281188-0cql96hu	213	2	,	,	,
cord-281188-0cql96hu	213	3	the	the	DT
cord-281188-0cql96hu	213	4	quinolone	quinolone	NNP
cord-281188-0cql96hu	213	5	-	-	HYPH
cord-281188-0cql96hu	213	6	gyrase	gyrase	NN
cord-281188-0cql96hu	213	7	-	-	HYPH
cord-281188-0cql96hu	213	8	DNA	dna	NN
cord-281188-0cql96hu	213	9	complexes	complex	NNS
cord-281188-0cql96hu	213	10	are	be	VBP
cord-281188-0cql96hu	213	11	unstable	unstable	JJ
cord-281188-0cql96hu	213	12	,	,	,
cord-281188-0cql96hu	213	13	and	and	CC
cord-281188-0cql96hu	213	14	bacteria	bacteria	NNS
cord-281188-0cql96hu	213	15	can	can	MD
cord-281188-0cql96hu	213	16	recover	recover	VB
cord-281188-0cql96hu	213	17	in	in	IN
cord-281188-0cql96hu	213	18	the	the	DT
cord-281188-0cql96hu	213	19	absence	absence	NN
cord-281188-0cql96hu	213	20	of	of	IN
cord-281188-0cql96hu	213	21	quinolone	quinolone	NNP
cord-281188-0cql96hu	213	22	exposure	exposure	NN
cord-281188-0cql96hu	213	23	.	.	.
cord-281188-0cql96hu	214	1	which	which	WDT
cord-281188-0cql96hu	214	2	results	result	VBZ
cord-281188-0cql96hu	214	3	in	in	IN
cord-281188-0cql96hu	214	4	structural	structural	JJ
cord-281188-0cql96hu	214	5	damage	damage	NN
cord-281188-0cql96hu	214	6	and/or	and/or	CC
cord-281188-0cql96hu	214	7	quantitative	quantitative	JJ
cord-281188-0cql96hu	214	8	or	or	CC
cord-281188-0cql96hu	214	9	qualitative	qualitative	JJ
cord-281188-0cql96hu	214	10	deficiencies	deficiency	NNS
cord-281188-0cql96hu	214	11	of	of	IN
cord-281188-0cql96hu	214	12	essential	essential	JJ
cord-281188-0cql96hu	214	13	cell	cell	NN
cord-281188-0cql96hu	214	14	components	component	NNS
cord-281188-0cql96hu	214	15	.	.	.
cord-281188-0cql96hu	215	1	These	these	DT
cord-281188-0cql96hu	215	2	changes	change	NNS
cord-281188-0cql96hu	215	3	,	,	,
cord-281188-0cql96hu	215	4	in	in	IN
cord-281188-0cql96hu	215	5	turn	turn	NN
cord-281188-0cql96hu	215	6	,	,	,
cord-281188-0cql96hu	215	7	lead	lead	VB
cord-281188-0cql96hu	215	8	to	to	IN
cord-281188-0cql96hu	215	9	envelope	envelope	NN
cord-281188-0cql96hu	215	10	stress	stress	NN
cord-281188-0cql96hu	215	11	,	,	,
cord-281188-0cql96hu	215	12	DNA	dna	NN
cord-281188-0cql96hu	215	13	damage	damage	NN
cord-281188-0cql96hu	215	14	and/or	and/or	CC
cord-281188-0cql96hu	215	15	the	the	DT
cord-281188-0cql96hu	215	16	production	production	NN
cord-281188-0cql96hu	215	17	of	of	IN
cord-281188-0cql96hu	215	18	an	an	DT
cord-281188-0cql96hu	215	19	excess	excess	NN
cord-281188-0cql96hu	215	20	of	of	IN
cord-281188-0cql96hu	215	21	reactive	reactive	JJ
cord-281188-0cql96hu	215	22	oxygen	oxygen	NN
cord-281188-0cql96hu	215	23	species	specie	NNS
cord-281188-0cql96hu	215	24	,	,	,
cord-281188-0cql96hu	215	25	which	which	WDT
cord-281188-0cql96hu	215	26	further	further	RB
cord-281188-0cql96hu	215	27	contribute	contribute	VBP
cord-281188-0cql96hu	215	28	to	to	IN
cord-281188-0cql96hu	215	29	the	the	DT
cord-281188-0cql96hu	215	30	destructuring	destructuring	NN
cord-281188-0cql96hu	215	31	of	of	IN
cord-281188-0cql96hu	215	32	cell	cell	NN
cord-281188-0cql96hu	215	33	membranes	membrane	NNS
cord-281188-0cql96hu	215	34	and	and	CC
cord-281188-0cql96hu	215	35	nucleic	nucleic	JJ
cord-281188-0cql96hu	215	36	acids	acid	NNS
cord-281188-0cql96hu	215	37	.	.	.
cord-281188-0cql96hu	216	1	The	the	DT
cord-281188-0cql96hu	216	2	net	net	JJ
cord-281188-0cql96hu	216	3	effect	effect	NN
cord-281188-0cql96hu	216	4	of	of	IN
cord-281188-0cql96hu	216	5	these	these	DT
cord-281188-0cql96hu	216	6	different	different	JJ
cord-281188-0cql96hu	216	7	processes	process	NNS
cord-281188-0cql96hu	216	8	(	(	-LRB-
cord-281188-0cql96hu	216	9	green	green	NNP
cord-281188-0cql96hu	216	10	)	)	-RRB-
cord-281188-0cql96hu	216	11	is	be	VBZ
cord-281188-0cql96hu	216	12	the	the	DT
cord-281188-0cql96hu	216	13	ultimate	ultimate	JJ
cord-281188-0cql96hu	216	14	mechanism	mechanism	NN
cord-281188-0cql96hu	216	15	responsible	responsible	JJ
cord-281188-0cql96hu	216	16	for	for	IN
cord-281188-0cql96hu	216	17	the	the	DT
cord-281188-0cql96hu	216	18	loss	loss	NN
cord-281188-0cql96hu	216	19	of	of	IN
cord-281188-0cql96hu	216	20	the	the	DT
cord-281188-0cql96hu	216	21	cell	cell	NN
cord-281188-0cql96hu	216	22	's	's	POS
cord-281188-0cql96hu	216	23	individuality	individuality	NN
cord-281188-0cql96hu	216	24	,	,	,
cord-281188-0cql96hu	216	25	its	-PRON-	PRP$
cord-281188-0cql96hu	216	26	death	death	NN
cord-281188-0cql96hu	216	27	(	(	-LRB-
cord-281188-0cql96hu	216	28	red	red	NN
cord-281188-0cql96hu	216	29	)	)	-RRB-
cord-281188-0cql96hu	216	30	.	.	.
cord-281188-0cql96hu	217	1	However	however	RB
cord-281188-0cql96hu	217	2	,	,	,
cord-281188-0cql96hu	217	3	if	if	IN
cord-281188-0cql96hu	217	4	exposure	exposure	NN
cord-281188-0cql96hu	217	5	is	be	VBZ
cord-281188-0cql96hu	217	6	maintained	maintain	VBN
cord-281188-0cql96hu	217	7	,	,	,
cord-281188-0cql96hu	217	8	the	the	DT
cord-281188-0cql96hu	217	9	complexes	complex	NNS
cord-281188-0cql96hu	217	10	become	become	VBP
cord-281188-0cql96hu	217	11	stable	stable	JJ
cord-281188-0cql96hu	217	12	,	,	,
cord-281188-0cql96hu	217	13	the	the	DT
cord-281188-0cql96hu	217	14	SOS	SOS	NNP
cord-281188-0cql96hu	217	15	response	response	NN
cord-281188-0cql96hu	217	16	continues	continue	VBZ
cord-281188-0cql96hu	217	17	and	and	CC
cord-281188-0cql96hu	217	18	when	when	WRB
cord-281188-0cql96hu	217	19	a	a	DT
cord-281188-0cql96hu	217	20	threshold	threshold	NN
cord-281188-0cql96hu	217	21	is	be	VBZ
cord-281188-0cql96hu	217	22	crossed	cross	VBN
cord-281188-0cql96hu	217	23	,	,	,
cord-281188-0cql96hu	217	24	the	the	DT
cord-281188-0cql96hu	217	25	death	death	NN
cord-281188-0cql96hu	217	26	process	process	NN
cord-281188-0cql96hu	217	27	becomes	become	VBZ
cord-281188-0cql96hu	217	28	irreversible	irreversible	JJ
cord-281188-0cql96hu	217	29	,	,	,
cord-281188-0cql96hu	217	30	even	even	RB
cord-281188-0cql96hu	217	31	in	in	IN
cord-281188-0cql96hu	217	32	the	the	DT
cord-281188-0cql96hu	217	33	absence	absence	NN
cord-281188-0cql96hu	217	34	of	of	IN
cord-281188-0cql96hu	217	35	the	the	DT
cord-281188-0cql96hu	217	36	drug	drug	NN
cord-281188-0cql96hu	217	37	34	34	CD
cord-281188-0cql96hu	217	38	,	,	,
cord-281188-0cql96hu	217	39	107	107	CD
cord-281188-0cql96hu	217	40	.	.	.
cord-281188-0cql96hu	218	1	The	the	DT
cord-281188-0cql96hu	218	2	activity	activity	NN
cord-281188-0cql96hu	218	3	of	of	IN
cord-281188-0cql96hu	218	4	ciprofloxacin	ciprofloxacin	NN
cord-281188-0cql96hu	218	5	decreases	decrease	VBZ
cord-281188-0cql96hu	218	6	when	when	WRB
cord-281188-0cql96hu	218	7	bacteria	bacteria	NNS
cord-281188-0cql96hu	218	8	reduce	reduce	VBP
cord-281188-0cql96hu	218	9	their	-PRON-	PRP$
cord-281188-0cql96hu	218	10	growth	growth	NN
cord-281188-0cql96hu	218	11	rates	rate	NNS
cord-281188-0cql96hu	218	12	108	108	CD
cord-281188-0cql96hu	218	13	.	.	.
cord-281188-0cql96hu	219	1	This	this	DT
cord-281188-0cql96hu	219	2	effect	effect	NN
cord-281188-0cql96hu	219	3	might	may	MD
cord-281188-0cql96hu	219	4	contribute	contribute	VB
cord-281188-0cql96hu	219	5	to	to	IN
cord-281188-0cql96hu	219	6	explaining	explain	VBG
cord-281188-0cql96hu	219	7	the	the	DT
cord-281188-0cql96hu	219	8	biphasic	biphasic	JJ
cord-281188-0cql96hu	219	9	dose	dose	NN
cord-281188-0cql96hu	219	10	response	response	NN
cord-281188-0cql96hu	219	11	of	of	IN
cord-281188-0cql96hu	219	12	most	most	JJS
cord-281188-0cql96hu	219	13	quinolones	quinolone	NNS
cord-281188-0cql96hu	219	14	,	,	,
cord-281188-0cql96hu	219	15	producing	produce	VBG
cord-281188-0cql96hu	219	16	a	a	DT
cord-281188-0cql96hu	219	17	single	single	JJ
cord-281188-0cql96hu	219	18	concentration	concentration	NN
cord-281188-0cql96hu	219	19	of	of	IN
cord-281188-0cql96hu	219	20	maximum	maximum	JJ
cord-281188-0cql96hu	219	21	kill	kill	NN
cord-281188-0cql96hu	219	22	.	.	.
cord-281188-0cql96hu	220	1	The	the	DT
cord-281188-0cql96hu	220	2	optimal	optimal	JJ
cord-281188-0cql96hu	220	3	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	220	4	concentration	concentration	NN
cord-281188-0cql96hu	220	5	probably	probably	RB
cord-281188-0cql96hu	220	6	depends	depend	VBZ
cord-281188-0cql96hu	220	7	on	on	IN
cord-281188-0cql96hu	220	8	the	the	DT
cord-281188-0cql96hu	220	9	SOS	SOS	NNP
cord-281188-0cql96hu	220	10	response	response	NN
cord-281188-0cql96hu	220	11	,	,	,
cord-281188-0cql96hu	220	12	the	the	DT
cord-281188-0cql96hu	220	13	formation	formation	NN
cord-281188-0cql96hu	220	14	of	of	IN
cord-281188-0cql96hu	220	15	superoxides	superoxides	NNP
cord-281188-0cql96hu	220	16	and	and	CC
cord-281188-0cql96hu	220	17	DNA	dna	NN
cord-281188-0cql96hu	220	18	breaks	break	NNS
cord-281188-0cql96hu	220	19	.	.	.
cord-281188-0cql96hu	221	1	Concentrations	concentration	NNS
cord-281188-0cql96hu	221	2	higher	high	JJR
cord-281188-0cql96hu	221	3	than	than	IN
cord-281188-0cql96hu	221	4	the	the	DT
cord-281188-0cql96hu	221	5	optimal	optimal	JJ
cord-281188-0cql96hu	221	6	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	221	7	concentration	concentration	NN
cord-281188-0cql96hu	221	8	provoke	provoke	VBP
cord-281188-0cql96hu	221	9	an	an	DT
cord-281188-0cql96hu	221	10	immediate	immediate	JJ
cord-281188-0cql96hu	221	11	SOS	SOS	NNP
cord-281188-0cql96hu	221	12	-	-	HYPH
cord-281188-0cql96hu	221	13	independent	independent	JJ
cord-281188-0cql96hu	221	14	inhibition	inhibition	NN
cord-281188-0cql96hu	221	15	of	of	IN
cord-281188-0cql96hu	221	16	respiration	respiration	NN
cord-281188-0cql96hu	221	17	and	and	CC
cord-281188-0cql96hu	221	18	growth	growth	NN
cord-281188-0cql96hu	221	19	,	,	,
cord-281188-0cql96hu	221	20	with	with	IN
cord-281188-0cql96hu	221	21	decreased	decrease	VBN
cord-281188-0cql96hu	221	22	ROS	ROS	NNP
cord-281188-0cql96hu	221	23	production	production	NN
cord-281188-0cql96hu	221	24	and	and	CC
cord-281188-0cql96hu	221	25	less	less	JJR
cord-281188-0cql96hu	221	26	death	death	NN
cord-281188-0cql96hu	221	27	108	108	CD
cord-281188-0cql96hu	221	28	.	.	.
cord-281188-0cql96hu	222	1	Conversely	conversely	RB
cord-281188-0cql96hu	222	2	,	,	,
cord-281188-0cql96hu	222	3	at	at	IN
cord-281188-0cql96hu	222	4	the	the	DT
cord-281188-0cql96hu	222	5	optimal	optimal	JJ
cord-281188-0cql96hu	222	6	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	222	7	concentration	concentration	NN
cord-281188-0cql96hu	222	8	,	,	,
cord-281188-0cql96hu	222	9	SOS	SOS	NNP
cord-281188-0cql96hu	222	10	-	-	HYPH
cord-281188-0cql96hu	222	11	derived	derive	VBN
cord-281188-0cql96hu	222	12	apoptosis	apoptosis	NN
cord-281188-0cql96hu	222	13	-	-	HYPH
cord-281188-0cql96hu	222	14	like	like	JJ
cord-281188-0cql96hu	222	15	death	death	NN
cord-281188-0cql96hu	222	16	occurs	occur	VBZ
cord-281188-0cql96hu	222	17	.	.	.
cord-281188-0cql96hu	223	1	This	this	DT
cord-281188-0cql96hu	223	2	pathway	pathway	NN
cord-281188-0cql96hu	223	3	depends	depend	VBZ
cord-281188-0cql96hu	223	4	on	on	IN
cord-281188-0cql96hu	223	5	RecA	RecA	NNP
cord-281188-0cql96hu	223	6	and	and	CC
cord-281188-0cql96hu	223	7	LexA	LexA	NNP
cord-281188-0cql96hu	223	8	,	,	,
cord-281188-0cql96hu	223	9	resulting	result	VBG
cord-281188-0cql96hu	223	10	in	in	IN
cord-281188-0cql96hu	223	11	cell	cell	NN
cord-281188-0cql96hu	223	12	death	death	NN
cord-281188-0cql96hu	223	13	associated	associate	VBN
cord-281188-0cql96hu	223	14	with	with	IN
cord-281188-0cql96hu	223	15	membrane	membrane	NN
cord-281188-0cql96hu	223	16	depolarization	depolarization	NN
cord-281188-0cql96hu	223	17	and	and	CC
cord-281188-0cql96hu	223	18	ROS	ROS	NNP
cord-281188-0cql96hu	223	19	-	-	HYPH
cord-281188-0cql96hu	223	20	induced	induce	VBN
cord-281188-0cql96hu	223	21	DNA	dna	NN
cord-281188-0cql96hu	223	22	fragmentation	fragmentation	NN
cord-281188-0cql96hu	223	23	83	83	CD
cord-281188-0cql96hu	223	24	.	.	.
cord-281188-0cql96hu	224	1	In	in	IN
cord-281188-0cql96hu	224	2	summary	summary	NN
cord-281188-0cql96hu	224	3	,	,	,
cord-281188-0cql96hu	224	4	ultimate	ultimate	JJ
cord-281188-0cql96hu	224	5	death	death	NN
cord-281188-0cql96hu	224	6	by	by	IN
cord-281188-0cql96hu	224	7	quinolones	quinolone	NNS
cord-281188-0cql96hu	224	8	occurs	occur	VBZ
cord-281188-0cql96hu	224	9	by	by	IN
cord-281188-0cql96hu	224	10	the	the	DT
cord-281188-0cql96hu	224	11	disintegration	disintegration	NN
cord-281188-0cql96hu	224	12	of	of	IN
cord-281188-0cql96hu	224	13	DNA	dna	NN
cord-281188-0cql96hu	224	14	mediated	mediate	VBN
cord-281188-0cql96hu	224	15	by	by	IN
cord-281188-0cql96hu	224	16	ROS	ROS	NNP
cord-281188-0cql96hu	224	17	34	34	CD
cord-281188-0cql96hu	224	18	.	.	.
cord-281188-0cql96hu	225	1	Rifamycins	Rifamycins	NNP
cord-281188-0cql96hu	225	2	.	.	.
cord-281188-0cql96hu	226	1	The	the	DT
cord-281188-0cql96hu	226	2	target	target	NN
cord-281188-0cql96hu	226	3	of	of	IN
cord-281188-0cql96hu	226	4	rifampin	rifampin	NN
cord-281188-0cql96hu	226	5	(	(	-LRB-
cord-281188-0cql96hu	226	6	and	and	CC
cord-281188-0cql96hu	226	7	,	,	,
cord-281188-0cql96hu	226	8	in	in	IN
cord-281188-0cql96hu	226	9	general	general	JJ
cord-281188-0cql96hu	226	10	,	,	,
cord-281188-0cql96hu	226	11	rifamycins	rifamycins	NNP
cord-281188-0cql96hu	226	12	)	)	-RRB-
cord-281188-0cql96hu	226	13	is	be	VBZ
cord-281188-0cql96hu	226	14	the	the	DT
cord-281188-0cql96hu	226	15	product	product	NN
cord-281188-0cql96hu	226	16	of	of	IN
cord-281188-0cql96hu	226	17	the	the	DT
cord-281188-0cql96hu	226	18	rpoB	rpob	CD
cord-281188-0cql96hu	226	19	gene	gene	NN
cord-281188-0cql96hu	226	20	,	,	,
cord-281188-0cql96hu	226	21	the	the	DT
cord-281188-0cql96hu	226	22	DNA	dna	NN
cord-281188-0cql96hu	226	23	-	-	HYPH
cord-281188-0cql96hu	226	24	dependent	dependent	JJ
cord-281188-0cql96hu	226	25	RNA	RNA	NNP
cord-281188-0cql96hu	226	26	polymerase	polymerase	NN
cord-281188-0cql96hu	226	27	.	.	.
cord-281188-0cql96hu	227	1	The	the	DT
cord-281188-0cql96hu	227	2	drug	drug	NN
cord-281188-0cql96hu	227	3	strongly	strongly	RB
cord-281188-0cql96hu	227	4	binds	bind	VBZ
cord-281188-0cql96hu	227	5	to	to	IN
cord-281188-0cql96hu	227	6	the	the	DT
cord-281188-0cql96hu	227	7	β	β	NN
cord-281188-0cql96hu	227	8	-	-	HYPH
cord-281188-0cql96hu	227	9	subunit	subunit	NN
cord-281188-0cql96hu	227	10	of	of	IN
cord-281188-0cql96hu	227	11	the	the	DT
cord-281188-0cql96hu	227	12	core	core	NN
cord-281188-0cql96hu	227	13	enzyme	enzyme	NN
cord-281188-0cql96hu	227	14	,	,	,
cord-281188-0cql96hu	227	15	thereby	thereby	RB
cord-281188-0cql96hu	227	16	inhibiting	inhibit	VBG
cord-281188-0cql96hu	227	17	initiation	initiation	NN
cord-281188-0cql96hu	227	18	of	of	IN
cord-281188-0cql96hu	227	19	transcription	transcription	NN
cord-281188-0cql96hu	227	20	;	;	:
cord-281188-0cql96hu	227	21	that	that	RB
cord-281188-0cql96hu	227	22	is	is	RB
cord-281188-0cql96hu	227	23	,	,	,
cord-281188-0cql96hu	227	24	preventing	prevent	VBG
cord-281188-0cql96hu	227	25	effective	effective	JJ
cord-281188-0cql96hu	227	26	protein	protein	NN
cord-281188-0cql96hu	227	27	synthesis	synthesis	NN
cord-281188-0cql96hu	227	28	109	109	CD
cord-281188-0cql96hu	227	29	.	.	.
cord-281188-0cql96hu	228	1	On	on	IN
cord-281188-0cql96hu	228	2	first	first	JJ
cord-281188-0cql96hu	228	3	consideration	consideration	NN
cord-281188-0cql96hu	228	4	,	,	,
cord-281188-0cql96hu	228	5	it	-PRON-	PRP
cord-281188-0cql96hu	228	6	may	may	MD
cord-281188-0cql96hu	228	7	seem	seem	VB
cord-281188-0cql96hu	228	8	that	that	IN
cord-281188-0cql96hu	228	9	inhibition	inhibition	NN
cord-281188-0cql96hu	228	10	of	of	IN
cord-281188-0cql96hu	228	11	protein	protein	NN
cord-281188-0cql96hu	228	12	synthesis	synthesis	NN
cord-281188-0cql96hu	228	13	is	be	VBZ
cord-281188-0cql96hu	228	14	not	not	RB
cord-281188-0cql96hu	228	15	sufficient	sufficient	JJ
cord-281188-0cql96hu	228	16	to	to	TO
cord-281188-0cql96hu	228	17	provide	provide	VB
cord-281188-0cql96hu	228	18	rapid	rapid	JJ
cord-281188-0cql96hu	228	19	killing	killing	NN
cord-281188-0cql96hu	228	20	.	.	.
cord-281188-0cql96hu	229	1	However	however	RB
cord-281188-0cql96hu	229	2	,	,	,
cord-281188-0cql96hu	229	3	in	in	IN
cord-281188-0cql96hu	229	4	practice	practice	NN
cord-281188-0cql96hu	229	5	,	,	,
cord-281188-0cql96hu	229	6	rifamycins	rifamycin	NNS
cord-281188-0cql96hu	229	7	are	be	VBP
cord-281188-0cql96hu	229	8	considered	consider	VBN
cord-281188-0cql96hu	229	9	to	to	TO
cord-281188-0cql96hu	229	10	have	have	VB
cord-281188-0cql96hu	229	11	an	an	DT
cord-281188-0cql96hu	229	12	early	early	JJ
cord-281188-0cql96hu	229	13	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	229	14	effect	effect	NN
cord-281188-0cql96hu	229	15	,	,	,
cord-281188-0cql96hu	229	16	not	not	RB
cord-281188-0cql96hu	229	17	only	only	RB
cord-281188-0cql96hu	229	18	in	in	IN
cord-281188-0cql96hu	229	19	S.	S.	NNP
cord-281188-0cql96hu	229	20	aureus	aureus	NN
cord-281188-0cql96hu	229	21	(	(	-LRB-
cord-281188-0cql96hu	229	22	fig	fig	NN
cord-281188-0cql96hu	229	23	.	.	NNP
cord-281188-0cql96hu	229	24	1	1	CD
cord-281188-0cql96hu	229	25	)	)	-RRB-
cord-281188-0cql96hu	229	26	and	and	CC
cord-281188-0cql96hu	229	27	E.	E.	NNP
cord-281188-0cql96hu	229	28	coli	coli	NNS
cord-281188-0cql96hu	229	29	,	,	,
cord-281188-0cql96hu	229	30	but	but	CC
cord-281188-0cql96hu	229	31	even	even	RB
cord-281188-0cql96hu	229	32	in	in	IN
cord-281188-0cql96hu	229	33	slowly	slowly	RB
cord-281188-0cql96hu	229	34	growing	grow	VBG
cord-281188-0cql96hu	229	35	bacteria	bacteria	NNS
cord-281188-0cql96hu	229	36	such	such	JJ
cord-281188-0cql96hu	229	37	as	as	IN
cord-281188-0cql96hu	229	38	Mycobacterium	Mycobacterium	NNP
cord-281188-0cql96hu	229	39	tuberculosis	tuberculosis	NN
cord-281188-0cql96hu	229	40	.	.	.
cord-281188-0cql96hu	230	1	In	in	IN
cord-281188-0cql96hu	230	2	addition	addition	NN
cord-281188-0cql96hu	230	3	,	,	,
cord-281188-0cql96hu	230	4	the	the	DT
cord-281188-0cql96hu	230	5	killing	killing	NN
cord-281188-0cql96hu	230	6	effect	effect	NN
cord-281188-0cql96hu	230	7	of	of	IN
cord-281188-0cql96hu	230	8	rifampin	rifampin	NN
cord-281188-0cql96hu	230	9	is	be	VBZ
cord-281188-0cql96hu	230	10	concentration	concentration	NN
cord-281188-0cql96hu	230	11	dependent	dependent	JJ
cord-281188-0cql96hu	230	12	10	10	CD
cord-281188-0cql96hu	230	13	,	,	,
cord-281188-0cql96hu	230	14	110	110	CD
cord-281188-0cql96hu	230	15	.	.	.
cord-281188-0cql96hu	231	1	High	high	JJ
cord-281188-0cql96hu	231	2	rifampin	rifampin	NN
cord-281188-0cql96hu	231	3	concentrations	concentration	NNS
cord-281188-0cql96hu	231	4	can	can	MD
cord-281188-0cql96hu	231	5	even	even	RB
cord-281188-0cql96hu	231	6	kill	kill	VB
cord-281188-0cql96hu	231	7	bacteria	bacteria	NNS
cord-281188-0cql96hu	231	8	with	with	IN
cord-281188-0cql96hu	231	9	some	some	DT
cord-281188-0cql96hu	231	10	types	type	NNS
cord-281188-0cql96hu	231	11	of	of	IN
cord-281188-0cql96hu	231	12	resistance	resistance	NN
cord-281188-0cql96hu	231	13	mutations	mutation	NNS
cord-281188-0cql96hu	231	14	in	in	IN
cord-281188-0cql96hu	231	15	the	the	DT
cord-281188-0cql96hu	231	16	rpoB	rpob	CD
cord-281188-0cql96hu	231	17	gene	gene	NN
cord-281188-0cql96hu	231	18	111	111	CD
cord-281188-0cql96hu	231	19	.	.	.
cord-281188-0cql96hu	232	1	By	by	IN
cord-281188-0cql96hu	232	2	targeting	target	VBG
cord-281188-0cql96hu	232	3	RNA	RNA	NNP
cord-281188-0cql96hu	232	4	polymerases	polymerase	NNS
cord-281188-0cql96hu	232	5	,	,	,
cord-281188-0cql96hu	232	6	rifamycins	rifamycin	NNS
cord-281188-0cql96hu	232	7	affect	affect	VBP
cord-281188-0cql96hu	232	8	both	both	DT
cord-281188-0cql96hu	232	9	translation	translation	NN
cord-281188-0cql96hu	232	10	and	and	CC
cord-281188-0cql96hu	232	11	transcription	transcription	NN
cord-281188-0cql96hu	232	12	,	,	,
cord-281188-0cql96hu	232	13	which	which	WDT
cord-281188-0cql96hu	232	14	together	together	RB
cord-281188-0cql96hu	232	15	ensure	ensure	VBP
cord-281188-0cql96hu	232	16	the	the	DT
cord-281188-0cql96hu	232	17	coordination	coordination	NN
cord-281188-0cql96hu	232	18	of	of	IN
cord-281188-0cql96hu	232	19	transcriptional	transcriptional	JJ
cord-281188-0cql96hu	232	20	activity	activity	NN
cord-281188-0cql96hu	232	21	to	to	IN
cord-281188-0cql96hu	232	22	the	the	DT
cord-281188-0cql96hu	232	23	translational	translational	JJ
cord-281188-0cql96hu	232	24	needs	need	NNS
cord-281188-0cql96hu	232	25	under	under	IN
cord-281188-0cql96hu	232	26	various	various	JJ
cord-281188-0cql96hu	232	27	growth	growth	NN
cord-281188-0cql96hu	232	28	rates	rate	NNS
cord-281188-0cql96hu	232	29	112	112	CD
cord-281188-0cql96hu	232	30	,	,	,
cord-281188-0cql96hu	232	31	113	113	CD
cord-281188-0cql96hu	232	32	.	.	.
cord-281188-0cql96hu	233	1	An	an	DT
cord-281188-0cql96hu	233	2	interesting	interesting	JJ
cord-281188-0cql96hu	233	3	question	question	NN
cord-281188-0cql96hu	233	4	is	be	VBZ
cord-281188-0cql96hu	233	5	whether	whether	IN
cord-281188-0cql96hu	233	6	the	the	DT
cord-281188-0cql96hu	233	7	inhibition	inhibition	NN
cord-281188-0cql96hu	233	8	of	of	IN
cord-281188-0cql96hu	233	9	transcription	transcription	NN
cord-281188-0cql96hu	233	10	might	may	MD
cord-281188-0cql96hu	233	11	produce	produce	VB
cord-281188-0cql96hu	233	12	lethal	lethal	JJ
cord-281188-0cql96hu	233	13	effects	effect	NNS
cord-281188-0cql96hu	233	14	independently	independently	RB
cord-281188-0cql96hu	233	15	from	from	IN
cord-281188-0cql96hu	233	16	blocking	block	VBG
cord-281188-0cql96hu	233	17	protein	protein	NN
cord-281188-0cql96hu	233	18	synthesis	synthesis	NN
cord-281188-0cql96hu	233	19	.	.	.
cord-281188-0cql96hu	234	1	A	a	DT
cord-281188-0cql96hu	234	2	classic	classic	JJ
cord-281188-0cql96hu	234	3	transcription	transcription	NN
cord-281188-0cql96hu	234	4	inhibitor	inhibitor	NN
cord-281188-0cql96hu	234	5	is	be	VBZ
cord-281188-0cql96hu	234	6	the	the	DT
cord-281188-0cql96hu	234	7	toxin	toxin	NN
cord-281188-0cql96hu	234	8	MazF	MazF	NNP
cord-281188-0cql96hu	234	9	,	,	,
cord-281188-0cql96hu	234	10	a	a	DT
cord-281188-0cql96hu	234	11	component	component	NN
cord-281188-0cql96hu	234	12	of	of	IN
cord-281188-0cql96hu	234	13	the	the	DT
cord-281188-0cql96hu	234	14	stress	stress	NN
cord-281188-0cql96hu	234	15	-	-	HYPH
cord-281188-0cql96hu	234	16	induced	induce	VBN
cord-281188-0cql96hu	234	17	MazF	MazF	NNP
cord-281188-0cql96hu	234	18	-	-	HYPH
cord-281188-0cql96hu	234	19	MazE	MazE	NNP
cord-281188-0cql96hu	234	20	toxinantitoxin	toxinantitoxin	NN
cord-281188-0cql96hu	234	21	machinery	machinery	NN
cord-281188-0cql96hu	234	22	.	.	.
cord-281188-0cql96hu	235	1	In	in	IN
cord-281188-0cql96hu	235	2	the	the	DT
cord-281188-0cql96hu	235	3	absence	absence	NN
cord-281188-0cql96hu	235	4	of	of	IN
cord-281188-0cql96hu	235	5	the	the	DT
cord-281188-0cql96hu	235	6	antitoxin	antitoxin	NN
cord-281188-0cql96hu	236	1	MazE	MazE	NNP
cord-281188-0cql96hu	237	1	,	,	,
cord-281188-0cql96hu	237	2	MazF	MazF	NNP
cord-281188-0cql96hu	237	3	inhibits	inhibit	VBZ
cord-281188-0cql96hu	237	4	protein	protein	NN
cord-281188-0cql96hu	237	5	synthesis	synthesis	NN
cord-281188-0cql96hu	237	6	by	by	IN
cord-281188-0cql96hu	237	7	cleaving	cleave	VBG
cord-281188-0cql96hu	237	8	mRNA	mrna	NN
cord-281188-0cql96hu	237	9	,	,	,
cord-281188-0cql96hu	237	10	resulting	result	VBG
cord-281188-0cql96hu	237	11	in	in	IN
cord-281188-0cql96hu	237	12	later	later	JJ
cord-281188-0cql96hu	237	13	death	death	NN
cord-281188-0cql96hu	237	14	114	114	CD
cord-281188-0cql96hu	237	15	.	.	.
cord-281188-0cql96hu	238	1	What	what	WP
cord-281188-0cql96hu	238	2	are	be	VBP
cord-281188-0cql96hu	238	3	the	the	DT
cord-281188-0cql96hu	238	4	causes	cause	NNS
cord-281188-0cql96hu	238	5	of	of	IN
cord-281188-0cql96hu	238	6	death	death	NN
cord-281188-0cql96hu	238	7	?	?	.
cord-281188-0cql96hu	239	1	It	-PRON-	PRP
cord-281188-0cql96hu	239	2	has	have	VBZ
cord-281188-0cql96hu	239	3	been	be	VBN
cord-281188-0cql96hu	239	4	suggested	suggest	VBN
cord-281188-0cql96hu	239	5	that	that	IN
cord-281188-0cql96hu	239	6	there	there	EX
cord-281188-0cql96hu	239	7	are	be	VBP
cord-281188-0cql96hu	239	8	a	a	DT
cord-281188-0cql96hu	239	9	group	group	NN
cord-281188-0cql96hu	239	10	of	of	IN
cord-281188-0cql96hu	239	11	mRNAs	mRNAs	NNPS
cord-281188-0cql96hu	239	12	that	that	WDT
cord-281188-0cql96hu	239	13	are	be	VBP
cord-281188-0cql96hu	239	14	resistant	resistant	JJ
cord-281188-0cql96hu	239	15	to	to	IN
cord-281188-0cql96hu	239	16	cleavage	cleavage	NN
cord-281188-0cql96hu	239	17	by	by	IN
cord-281188-0cql96hu	239	18	MazF	MazF	NNP
cord-281188-0cql96hu	239	19	,	,	,
cord-281188-0cql96hu	239	20	encoding	encode	VBG
cord-281188-0cql96hu	239	21	'	'	POS
cord-281188-0cql96hu	239	22	death	death	NN
cord-281188-0cql96hu	239	23	proteins	protein	NNS
cord-281188-0cql96hu	239	24	'	'	POS
cord-281188-0cql96hu	239	25	,	,	,
cord-281188-0cql96hu	239	26	some	some	DT
cord-281188-0cql96hu	239	27	of	of	IN
cord-281188-0cql96hu	239	28	which	which	WDT
cord-281188-0cql96hu	239	29	damage	damage	NN
cord-281188-0cql96hu	239	30	cell	cell	NN
cord-281188-0cql96hu	239	31	envelopes	envelope	NNS
cord-281188-0cql96hu	239	32	115	115	CD
cord-281188-0cql96hu	239	33	.	.	.
cord-281188-0cql96hu	240	1	A	a	DT
cord-281188-0cql96hu	240	2	similar	similar	JJ
cord-281188-0cql96hu	240	3	mechanism	mechanism	NN
cord-281188-0cql96hu	240	4	of	of	IN
cord-281188-0cql96hu	240	5	death	death	NN
cord-281188-0cql96hu	240	6	can	can	MD
cord-281188-0cql96hu	240	7	be	be	VB
cord-281188-0cql96hu	240	8	suggested	suggest	VBN
cord-281188-0cql96hu	240	9	for	for	IN
cord-281188-0cql96hu	240	10	rifampin	rifampin	NN
cord-281188-0cql96hu	240	11	,	,	,
cord-281188-0cql96hu	240	12	which	which	WDT
cord-281188-0cql96hu	240	13	also	also	RB
cord-281188-0cql96hu	240	14	selectively	selectively	RB
cord-281188-0cql96hu	240	15	affects	affect	VBZ
cord-281188-0cql96hu	240	16	the	the	DT
cord-281188-0cql96hu	240	17	transcription	transcription	NN
cord-281188-0cql96hu	240	18	of	of	IN
cord-281188-0cql96hu	240	19	different	different	JJ
cord-281188-0cql96hu	240	20	genes	gene	NNS
cord-281188-0cql96hu	240	21	116	116	CD
cord-281188-0cql96hu	240	22	.	.	.
cord-281188-0cql96hu	241	1	It	-PRON-	PRP
cord-281188-0cql96hu	241	2	is	be	VBZ
cord-281188-0cql96hu	241	3	possible	possible	JJ
cord-281188-0cql96hu	241	4	that	that	IN
cord-281188-0cql96hu	241	5	rifampin	rifampin	NN
cord-281188-0cql96hu	241	6	,	,	,
cord-281188-0cql96hu	241	7	similarly	similarly	RB
cord-281188-0cql96hu	241	8	to	to	IN
cord-281188-0cql96hu	241	9	ribosome	ribosome	NN
cord-281188-0cql96hu	241	10	-	-	HYPH
cord-281188-0cql96hu	241	11	binding	bind	VBG
cord-281188-0cql96hu	241	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	241	13	,	,	,
cord-281188-0cql96hu	241	14	reshapes	reshape	VBZ
cord-281188-0cql96hu	241	15	the	the	DT
cord-281188-0cql96hu	241	16	cellular	cellular	JJ
cord-281188-0cql96hu	241	17	proteome	proteome	NN
cord-281188-0cql96hu	241	18	rather	rather	RB
cord-281188-0cql96hu	241	19	than	than	IN
cord-281188-0cql96hu	241	20	just	just	RB
cord-281188-0cql96hu	241	21	blocking	block	VBG
cord-281188-0cql96hu	241	22	global	global	JJ
cord-281188-0cql96hu	241	23	protein	protein	NN
cord-281188-0cql96hu	241	24	synthesis	synthesis	NN
cord-281188-0cql96hu	241	25	117	117	CD
cord-281188-0cql96hu	241	26	,	,	,
cord-281188-0cql96hu	241	27	118	118	CD
cord-281188-0cql96hu	241	28	,	,	,
cord-281188-0cql96hu	241	29	but	but	CC
cord-281188-0cql96hu	241	30	both	both	DT
cord-281188-0cql96hu	241	31	effects	effect	NNS
cord-281188-0cql96hu	241	32	might	may	MD
cord-281188-0cql96hu	241	33	be	be	VB
cord-281188-0cql96hu	241	34	synergistic	synergistic	JJ
cord-281188-0cql96hu	241	35	for	for	IN
cord-281188-0cql96hu	241	36	killing	killing	NN
cord-281188-0cql96hu	241	37	,	,	,
cord-281188-0cql96hu	241	38	particularly	particularly	RB
cord-281188-0cql96hu	241	39	in	in	IN
cord-281188-0cql96hu	241	40	species	specie	NNS
cord-281188-0cql96hu	241	41	with	with	IN
cord-281188-0cql96hu	241	42	a	a	DT
cord-281188-0cql96hu	241	43	low	low	JJ
cord-281188-0cql96hu	241	44	number	number	NN
cord-281188-0cql96hu	241	45	of	of	IN
cord-281188-0cql96hu	241	46	rrn	rrn	NN
cord-281188-0cql96hu	241	47	operons	operon	NNS
cord-281188-0cql96hu	241	48	3	3	CD
cord-281188-0cql96hu	241	49	.	.	.
cord-281188-0cql96hu	242	1	Rifamycins	rifamycin	NNS
cord-281188-0cql96hu	242	2	do	do	VBP
cord-281188-0cql96hu	242	3	not	not	RB
cord-281188-0cql96hu	242	4	stimulate	stimulate	VB
cord-281188-0cql96hu	242	5	the	the	DT
cord-281188-0cql96hu	242	6	production	production	NN
cord-281188-0cql96hu	242	7	of	of	IN
cord-281188-0cql96hu	242	8	hydroxyl	hydroxyl	NN
cord-281188-0cql96hu	242	9	radical	radical	JJ
cord-281188-0cql96hu	242	10	production	production	NN
cord-281188-0cql96hu	242	11	,	,	,
cord-281188-0cql96hu	242	12	which	which	WDT
cord-281188-0cql96hu	242	13	could	could	MD
cord-281188-0cql96hu	242	14	contribute	contribute	VB
cord-281188-0cql96hu	242	15	to	to	IN
cord-281188-0cql96hu	242	16	cell	cell	NN
cord-281188-0cql96hu	242	17	death	death	NN
cord-281188-0cql96hu	242	18	32	32	CD
cord-281188-0cql96hu	242	19	.	.	.
cord-281188-0cql96hu	243	1	β	β	LS
cord-281188-0cql96hu	243	2	-	-	HYPH
cord-281188-0cql96hu	243	3	Lactam	Lactam	NNP
cord-281188-0cql96hu	243	4	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	243	5	.	.	.
cord-281188-0cql96hu	244	1	β	β	LS
cord-281188-0cql96hu	244	2	-	-	HYPH
cord-281188-0cql96hu	244	3	Lactams	Lactams	NNP
cord-281188-0cql96hu	244	4	target	target	VBP
cord-281188-0cql96hu	244	5	penicillin	penicillin	NN
cord-281188-0cql96hu	244	6	-	-	HYPH
cord-281188-0cql96hu	244	7	binding	bind	VBG
cord-281188-0cql96hu	244	8	proteins	protein	NNS
cord-281188-0cql96hu	244	9	involved	involve	VBN
cord-281188-0cql96hu	244	10	in	in	IN
cord-281188-0cql96hu	244	11	the	the	DT
cord-281188-0cql96hu	244	12	biogenesis	biogenesis	NN
cord-281188-0cql96hu	244	13	of	of	IN
cord-281188-0cql96hu	244	14	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	244	15	119	119	CD
cord-281188-0cql96hu	244	16	.	.	.
cord-281188-0cql96hu	245	1	There	there	EX
cord-281188-0cql96hu	245	2	is	be	VBZ
cord-281188-0cql96hu	245	3	a	a	DT
cord-281188-0cql96hu	245	4	clear	clear	JJ
cord-281188-0cql96hu	245	5	correlation	correlation	NN
cord-281188-0cql96hu	245	6	between	between	IN
cord-281188-0cql96hu	245	7	bacterial	bacterial	JJ
cord-281188-0cql96hu	245	8	growth	growth	NN
cord-281188-0cql96hu	245	9	rate	rate	NN
cord-281188-0cql96hu	245	10	,	,	,
cord-281188-0cql96hu	245	11	needs	need	NNS
cord-281188-0cql96hu	245	12	of	of	IN
cord-281188-0cql96hu	245	13	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	245	14	biogenesis	biogenesis	NN
cord-281188-0cql96hu	245	15	and	and	CC
cord-281188-0cql96hu	245	16	cell	cell	NN
cord-281188-0cql96hu	245	17	lysis	lysis	NN
cord-281188-0cql96hu	245	18	induced	induce	VBN
cord-281188-0cql96hu	245	19	by	by	IN
cord-281188-0cql96hu	245	20	β	β	NNP
cord-281188-0cql96hu	245	21	-	-	HYPH
cord-281188-0cql96hu	245	22	lactams	lactam	NNS
cord-281188-0cql96hu	245	23	37	37	CD
cord-281188-0cql96hu	245	24	.	.	.
cord-281188-0cql96hu	246	1	Lysis	lysis	NN
cord-281188-0cql96hu	246	2	requires	require	VBZ
cord-281188-0cql96hu	246	3	functional	functional	JJ
cord-281188-0cql96hu	246	4	assembly	assembly	NN
cord-281188-0cql96hu	246	5	of	of	IN
cord-281188-0cql96hu	246	6	the	the	DT
cord-281188-0cql96hu	246	7	divisome	divisome	NNP
cord-281188-0cql96hu	246	8	,	,	,
cord-281188-0cql96hu	246	9	the	the	DT
cord-281188-0cql96hu	246	10	cell	cell	NN
cord-281188-0cql96hu	246	11	division	division	NN
cord-281188-0cql96hu	246	12	machinery	machinery	NN
cord-281188-0cql96hu	246	13	120	120	CD
cord-281188-0cql96hu	246	14	,	,	,
cord-281188-0cql96hu	246	15	suggesting	suggest	VBG
cord-281188-0cql96hu	246	16	that	that	IN
cord-281188-0cql96hu	246	17	lysis	lysis	NN
cord-281188-0cql96hu	246	18	specifically	specifically	RB
cord-281188-0cql96hu	246	19	occurs	occur	VBZ
cord-281188-0cql96hu	246	20	when	when	WRB
cord-281188-0cql96hu	246	21	the	the	DT
cord-281188-0cql96hu	246	22	cell	cell	NN
cord-281188-0cql96hu	246	23	is	be	VBZ
cord-281188-0cql96hu	246	24	ready	ready	JJ
cord-281188-0cql96hu	246	25	for	for	IN
cord-281188-0cql96hu	246	26	division	division	NN
cord-281188-0cql96hu	246	27	121	121	CD
cord-281188-0cql96hu	246	28	.	.	.
cord-281188-0cql96hu	247	1	Why	why	WRB
cord-281188-0cql96hu	247	2	is	be	VBZ
cord-281188-0cql96hu	247	3	the	the	DT
cord-281188-0cql96hu	247	4	loss	loss	NN
cord-281188-0cql96hu	247	5	of	of	IN
cord-281188-0cql96hu	247	6	cell	cell	NN
cord-281188-0cql96hu	247	7	wall	wall	NN
cord-281188-0cql96hu	247	8	integrity	integrity	NN
cord-281188-0cql96hu	247	9	and	and	CC
cord-281188-0cql96hu	247	10	lysis	lysis	NN
cord-281188-0cql96hu	247	11	the	the	DT
cord-281188-0cql96hu	247	12	result	result	NN
cord-281188-0cql96hu	247	13	of	of	IN
cord-281188-0cql96hu	247	14	reduced	reduce	VBN
cord-281188-0cql96hu	247	15	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	247	16	biogenesis	biogenesis	NN
cord-281188-0cql96hu	247	17	?	?	.
cord-281188-0cql96hu	248	1	The	the	DT
cord-281188-0cql96hu	248	2	traditional	traditional	JJ
cord-281188-0cql96hu	248	3	answer	answer	NN
cord-281188-0cql96hu	248	4	is	be	VBZ
cord-281188-0cql96hu	248	5	induction	induction	NN
cord-281188-0cql96hu	248	6	of	of	IN
cord-281188-0cql96hu	248	7	peptidoglycan	peptidoglycan	NNP
cord-281188-0cql96hu	248	8	autolysins	autolysins	NNP
cord-281188-0cql96hu	248	9	122	122	CD
cord-281188-0cql96hu	248	10	or	or	CC
cord-281188-0cql96hu	248	11	simply	simply	RB
cord-281188-0cql96hu	248	12	that	that	IN
cord-281188-0cql96hu	248	13	these	these	DT
cord-281188-0cql96hu	248	14	lysins	lysin	NNS
cord-281188-0cql96hu	248	15	continue	continue	VBP
cord-281188-0cql96hu	248	16	their	-PRON-	PRP$
cord-281188-0cql96hu	248	17	activity	activity	NN
cord-281188-0cql96hu	248	18	without	without	IN
cord-281188-0cql96hu	248	19	compensation	compensation	NN
cord-281188-0cql96hu	248	20	by	by	IN
cord-281188-0cql96hu	248	21	biogenesis	biogenesis	NN
cord-281188-0cql96hu	248	22	(	(	-LRB-
cord-281188-0cql96hu	248	23	see	see	VB
cord-281188-0cql96hu	248	24	earlier	early	RBR
cord-281188-0cql96hu	248	25	)	)	-RRB-
cord-281188-0cql96hu	248	26	.	.	.
cord-281188-0cql96hu	249	1	More	more	RBR
cord-281188-0cql96hu	249	2	recently	recently	RB
cord-281188-0cql96hu	249	3	,	,	,
cord-281188-0cql96hu	249	4	it	-PRON-	PRP
cord-281188-0cql96hu	249	5	has	have	VBZ
cord-281188-0cql96hu	249	6	been	be	VBN
cord-281188-0cql96hu	249	7	proposed	propose	VBN
cord-281188-0cql96hu	249	8	that	that	DT
cord-281188-0cql96hu	249	9	inhibition	inhibition	NN
cord-281188-0cql96hu	249	10	of	of	IN
cord-281188-0cql96hu	249	11	penicillin	penicillin	NN
cord-281188-0cql96hu	249	12	-	-	HYPH
cord-281188-0cql96hu	249	13	binding	bind	VBG
cord-281188-0cql96hu	249	14	proteins	protein	NNS
cord-281188-0cql96hu	249	15	by	by	IN
cord-281188-0cql96hu	249	16	β	β	NN
cord-281188-0cql96hu	249	17	-	-	HYPH
cord-281188-0cql96hu	249	18	lactams	lactams	NNP
cord-281188-0cql96hu	249	19	produces	produce	VBZ
cord-281188-0cql96hu	249	20	a	a	DT
cord-281188-0cql96hu	249	21	deleterious	deleterious	JJ
cord-281188-0cql96hu	249	22	'	'	``
cord-281188-0cql96hu	249	23	futile	futile	JJ
cord-281188-0cql96hu	249	24	cycle	cycle	NN
cord-281188-0cql96hu	249	25	'	'	''
cord-281188-0cql96hu	249	26	of	of	IN
cord-281188-0cql96hu	249	27	metabolic	metabolic	JJ
cord-281188-0cql96hu	249	28	pathways	pathway	NNS
cord-281188-0cql96hu	249	29	involved	involve	VBN
cord-281188-0cql96hu	249	30	in	in	IN
cord-281188-0cql96hu	249	31	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	249	32	synthesis	synthesis	NN
cord-281188-0cql96hu	249	33	and	and	CC
cord-281188-0cql96hu	249	34	degradation	degradation	NN
cord-281188-0cql96hu	249	35	running	run	VBG
cord-281188-0cql96hu	249	36	simultaneously	simultaneously	RB
cord-281188-0cql96hu	249	37	in	in	IN
cord-281188-0cql96hu	249	38	opposite	opposite	JJ
cord-281188-0cql96hu	249	39	directions	direction	NNS
cord-281188-0cql96hu	249	40	and	and	CC
cord-281188-0cql96hu	249	41	promoting	promote	VBG
cord-281188-0cql96hu	249	42	deintegration	deintegration	NN
cord-281188-0cql96hu	249	43	and	and	CC
cord-281188-0cql96hu	249	44	lysis	lysis	NN
cord-281188-0cql96hu	249	45	123	123	CD
cord-281188-0cql96hu	249	46	.	.	.
cord-281188-0cql96hu	250	1	Besides	besides	RB
cord-281188-0cql96hu	250	2	,	,	,
cord-281188-0cql96hu	250	3	disruption	disruption	NN
cord-281188-0cql96hu	250	4	of	of	IN
cord-281188-0cql96hu	250	5	cell	cell	NN
cord-281188-0cql96hu	250	6	envelope	envelope	NN
cord-281188-0cql96hu	250	7	integrity	integrity	NN
cord-281188-0cql96hu	250	8	,	,	,
cord-281188-0cql96hu	250	9	leading	lead	VBG
cord-281188-0cql96hu	250	10	to	to	IN
cord-281188-0cql96hu	250	11	bubbling	bubble	VBG
cord-281188-0cql96hu	250	12	and	and	CC
cord-281188-0cql96hu	250	13	'	'	``
cord-281188-0cql96hu	250	14	explosion	explosion	NN
cord-281188-0cql96hu	250	15	'	'	''
cord-281188-0cql96hu	250	16	of	of	IN
cord-281188-0cql96hu	250	17	the	the	DT
cord-281188-0cql96hu	250	18	cell	cell	NN
cord-281188-0cql96hu	250	19	,	,	,
cord-281188-0cql96hu	250	20	particularly	particularly	RB
cord-281188-0cql96hu	250	21	in	in	IN
cord-281188-0cql96hu	250	22	Gram	gram	NN
cord-281188-0cql96hu	250	23	-	-	HYPH
cord-281188-0cql96hu	250	24	negative	negative	JJ
cord-281188-0cql96hu	250	25	bacteria	bacteria	NNS
cord-281188-0cql96hu	250	26	,	,	,
cord-281188-0cql96hu	250	27	is	be	VBZ
cord-281188-0cql96hu	250	28	probably	probably	RB
cord-281188-0cql96hu	250	29	triggered	trigger	VBN
cord-281188-0cql96hu	250	30	by	by	IN
cord-281188-0cql96hu	250	31	lacking	lack	VBG
cord-281188-0cql96hu	250	32	coordination	coordination	NN
cord-281188-0cql96hu	250	33	of	of	IN
cord-281188-0cql96hu	250	34	the	the	DT
cord-281188-0cql96hu	250	35	multicomponent	multicomponent	NN
cord-281188-0cql96hu	250	36	machinery	machinery	NN
cord-281188-0cql96hu	250	37	that	that	WDT
cord-281188-0cql96hu	250	38	links	link	VBZ
cord-281188-0cql96hu	250	39	the	the	DT
cord-281188-0cql96hu	250	40	growth	growth	NN
cord-281188-0cql96hu	250	41	of	of	IN
cord-281188-0cql96hu	250	42	the	the	DT
cord-281188-0cql96hu	250	43	different	different	JJ
cord-281188-0cql96hu	250	44	envelope	envelope	NN
cord-281188-0cql96hu	250	45	layers	layer	NNS
cord-281188-0cql96hu	250	46	,	,	,
cord-281188-0cql96hu	250	47	and	and	CC
cord-281188-0cql96hu	250	48	involves	involve	VBZ
cord-281188-0cql96hu	250	49	sensing	sensing	NN
cord-281188-0cql96hu	250	50	of	of	IN
cord-281188-0cql96hu	250	51	unassembled	unassembled	JJ
cord-281188-0cql96hu	250	52	outer	outer	JJ
cord-281188-0cql96hu	250	53	membrane	membrane	NN
cord-281188-0cql96hu	250	54	proteins	protein	NNS
cord-281188-0cql96hu	250	55	and	and	CC
cord-281188-0cql96hu	250	56	LPS	lp	NNS
cord-281188-0cql96hu	250	57	in	in	IN
cord-281188-0cql96hu	250	58	the	the	DT
cord-281188-0cql96hu	250	59	periplasm	periplasm	NN
cord-281188-0cql96hu	250	60	123	123	CD
cord-281188-0cql96hu	250	61	.	.	.
cord-281188-0cql96hu	251	1	The	the	DT
cord-281188-0cql96hu	251	2	possibility	possibility	NN
cord-281188-0cql96hu	251	3	of	of	IN
cord-281188-0cql96hu	251	4	biophysical	biophysical	JJ
cord-281188-0cql96hu	251	5	shearing	shearing	NN
cord-281188-0cql96hu	251	6	of	of	IN
cord-281188-0cql96hu	251	7	different	different	JJ
cord-281188-0cql96hu	251	8	layers	layer	NNS
cord-281188-0cql96hu	251	9	,	,	,
cord-281188-0cql96hu	251	10	owing	owe	VBG
cord-281188-0cql96hu	251	11	to	to	IN
cord-281188-0cql96hu	251	12	disbalance	disbalance	NN
cord-281188-0cql96hu	251	13	between	between	IN
cord-281188-0cql96hu	251	14	cell	cell	NN
cord-281188-0cql96hu	251	15	wall	wall	NN
cord-281188-0cql96hu	251	16	and	and	CC
cord-281188-0cql96hu	251	17	membrane	membrane	NN
cord-281188-0cql96hu	251	18	growth	growth	NN
cord-281188-0cql96hu	251	19	[	[	-LRB-
cord-281188-0cql96hu	251	20	124	124	CD
cord-281188-0cql96hu	251	21	]	]	-RRB-
cord-281188-0cql96hu	251	22	[	[	-LRB-
cord-281188-0cql96hu	251	23	125	125	CD
cord-281188-0cql96hu	251	24	]	]	-RRB-
cord-281188-0cql96hu	251	25	[	[	-LRB-
cord-281188-0cql96hu	251	26	126	126	CD
cord-281188-0cql96hu	251	27	]	]	-RRB-
cord-281188-0cql96hu	251	28	and	and	CC
cord-281188-0cql96hu	251	29	resulting	result	VBG
cord-281188-0cql96hu	251	30	in	in	IN
cord-281188-0cql96hu	251	31	cell	cell	NN
cord-281188-0cql96hu	251	32	lysis	lysis	NN
cord-281188-0cql96hu	251	33	,	,	,
cord-281188-0cql96hu	251	34	can	can	MD
cord-281188-0cql96hu	251	35	not	not	RB
cord-281188-0cql96hu	251	36	be	be	VB
cord-281188-0cql96hu	251	37	discarded	discard	VBN
cord-281188-0cql96hu	251	38	and	and	CC
cord-281188-0cql96hu	251	39	is	be	VBZ
cord-281188-0cql96hu	251	40	worth	worth	JJ
cord-281188-0cql96hu	251	41	further	far	RBR
cord-281188-0cql96hu	251	42	and	and	CC
cord-281188-0cql96hu	251	43	deeper	deep	JJR
cord-281188-0cql96hu	251	44	consideration	consideration	NN
cord-281188-0cql96hu	251	45	.	.	.
cord-281188-0cql96hu	252	1	Finally	finally	RB
cord-281188-0cql96hu	252	2	,	,	,
cord-281188-0cql96hu	252	3	there	there	EX
cord-281188-0cql96hu	252	4	is	be	VBZ
cord-281188-0cql96hu	252	5	evidence	evidence	NN
cord-281188-0cql96hu	252	6	that	that	IN
cord-281188-0cql96hu	252	7	β	β	NN
cord-281188-0cql96hu	252	8	-	-	HYPH
cord-281188-0cql96hu	252	9	lactam	lactam	NN
cord-281188-0cql96hu	252	10	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	252	11	are	be	VBP
cord-281188-0cql96hu	252	12	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	252	13	through	through	IN
cord-281188-0cql96hu	252	14	DNA	dna	NN
cord-281188-0cql96hu	252	15	damage	damage	NN
cord-281188-0cql96hu	252	16	by	by	IN
cord-281188-0cql96hu	252	17	ROS	ROS	NNP
cord-281188-0cql96hu	252	18	34	34	CD
cord-281188-0cql96hu	252	19	,	,	,
cord-281188-0cql96hu	252	20	127	127	CD
cord-281188-0cql96hu	252	21	.	.	.
cord-281188-0cql96hu	253	1	Vancomycin	Vancomycin	NNP
cord-281188-0cql96hu	253	2	.	.	.
cord-281188-0cql96hu	254	1	Vancomycin	Vancomycin	NNP
cord-281188-0cql96hu	254	2	is	be	VBZ
cord-281188-0cql96hu	254	3	a	a	DT
cord-281188-0cql96hu	254	4	lipophilic	lipophilic	JJ
cord-281188-0cql96hu	254	5	cationic	cationic	JJ
cord-281188-0cql96hu	254	6	antibiotic	antibiotic	NN
cord-281188-0cql96hu	254	7	that	that	WDT
cord-281188-0cql96hu	254	8	inhibits	inhibit	VBZ
cord-281188-0cql96hu	254	9	synthesis	synthesis	NN
cord-281188-0cql96hu	254	10	of	of	IN
cord-281188-0cql96hu	254	11	the	the	DT
cord-281188-0cql96hu	254	12	bacterial	bacterial	JJ
cord-281188-0cql96hu	254	13	cell	cell	NN
cord-281188-0cql96hu	254	14	wall	wall	NN
cord-281188-0cql96hu	254	15	by	by	IN
cord-281188-0cql96hu	254	16	binding	bind	VBG
cord-281188-0cql96hu	254	17	to	to	IN
cord-281188-0cql96hu	254	18	the	the	DT
cord-281188-0cql96hu	254	19	dipeptide	dipeptide	JJ
cord-281188-0cql96hu	254	20	terminus	terminus	NN
cord-281188-0cql96hu	254	21	d	d	NNP
cord-281188-0cql96hu	254	22	-	-	:
cord-281188-0cql96hu	254	23	Ala	Ala	NNP
cord-281188-0cql96hu	254	24	-	-	HYPH
cord-281188-0cql96hu	254	25	d	d	NNP
cord-281188-0cql96hu	254	26	-	-	:
cord-281188-0cql96hu	254	27	Ala	Ala	NNP
cord-281188-0cql96hu	254	28	of	of	IN
cord-281188-0cql96hu	254	29	peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	254	30	pentapeptide	pentapeptide	NN
cord-281188-0cql96hu	254	31	precursors	precursor	NNS
cord-281188-0cql96hu	254	32	,	,	,
cord-281188-0cql96hu	254	33	preventing	prevent	VBG
cord-281188-0cql96hu	254	34	subsequent	subsequent	JJ
cord-281188-0cql96hu	254	35	transpeptidation	transpeptidation	NN
cord-281188-0cql96hu	254	36	and	and	CC
cord-281188-0cql96hu	254	37	transglycosylation	transglycosylation	NN
cord-281188-0cql96hu	254	38	and	and	CC
cord-281188-0cql96hu	254	39	thus	thus	RB
cord-281188-0cql96hu	254	40	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	254	41	crosslinking	crosslinke	VBG
cord-281188-0cql96hu	254	42	128	128	CD
cord-281188-0cql96hu	254	43	.	.	.
cord-281188-0cql96hu	255	1	Deficient	deficient	JJ
cord-281188-0cql96hu	255	2	crosslinking	crosslinking	NN
cord-281188-0cql96hu	255	3	of	of	IN
cord-281188-0cql96hu	255	4	the	the	DT
cord-281188-0cql96hu	255	5	long	long	JJ
cord-281188-0cql96hu	255	6	sugar	sugar	NN
cord-281188-0cql96hu	255	7	backbone	backbone	NN
cord-281188-0cql96hu	255	8	chains	chain	NNS
cord-281188-0cql96hu	255	9	of	of	IN
cord-281188-0cql96hu	255	10	N	n	CD
cord-281188-0cql96hu	255	11	-	-	HYPH
cord-281188-0cql96hu	255	12	acetylglucosamine/	acetylglucosamine/	NNP
cord-281188-0cql96hu	255	13	N	N	NNP
cord-281188-0cql96hu	255	14	-	-	HYPH
cord-281188-0cql96hu	255	15	acetylmuramic	acetylmuramic	JJ
cord-281188-0cql96hu	255	16	chains	chain	NNS
cord-281188-0cql96hu	255	17	results	result	NNS
cord-281188-0cql96hu	255	18	weakens	weaken	VBZ
cord-281188-0cql96hu	255	19	the	the	DT
cord-281188-0cql96hu	255	20	cell	cell	NN
cord-281188-0cql96hu	255	21	to	to	IN
cord-281188-0cql96hu	255	22	osmotic	osmotic	JJ
cord-281188-0cql96hu	255	23	damage	damage	NN
cord-281188-0cql96hu	255	24	,	,	,
cord-281188-0cql96hu	255	25	leading	lead	VBG
cord-281188-0cql96hu	255	26	to	to	IN
cord-281188-0cql96hu	255	27	cell	cell	NN
cord-281188-0cql96hu	255	28	disintegration	disintegration	NN
cord-281188-0cql96hu	255	29	.	.	.
cord-281188-0cql96hu	256	1	Similarly	similarly	RB
cord-281188-0cql96hu	256	2	,	,	,
cord-281188-0cql96hu	256	3	this	this	DT
cord-281188-0cql96hu	256	4	effect	effect	NN
cord-281188-0cql96hu	256	5	explains	explain	VBZ
cord-281188-0cql96hu	256	6	why	why	WRB
cord-281188-0cql96hu	256	7	vancomycin	vancomycin	NN
cord-281188-0cql96hu	256	8	-	-	HYPH
cord-281188-0cql96hu	256	9	exposed	expose	VBN
cord-281188-0cql96hu	256	10	cells	cell	NNS
cord-281188-0cql96hu	256	11	are	be	VBP
cord-281188-0cql96hu	256	12	much	much	RB
cord-281188-0cql96hu	256	13	more	more	RBR
cord-281188-0cql96hu	256	14	sensitive	sensitive	JJ
cord-281188-0cql96hu	256	15	to	to	IN
cord-281188-0cql96hu	256	16	ultrasound	ultrasound	NN
cord-281188-0cql96hu	256	17	25	25	CD
cord-281188-0cql96hu	256	18	.	.	.
cord-281188-0cql96hu	257	1	In	in	IN
cord-281188-0cql96hu	257	2	S.	S.	NNP
cord-281188-0cql96hu	257	3	aureus	aureus	NN
cord-281188-0cql96hu	257	4	,	,	,
cord-281188-0cql96hu	257	5	the	the	DT
cord-281188-0cql96hu	257	6	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	257	7	effect	effect	NN
cord-281188-0cql96hu	257	8	of	of	IN
cord-281188-0cql96hu	257	9	vancomycin	vancomycin	NN
cord-281188-0cql96hu	257	10	is	be	VBZ
cord-281188-0cql96hu	257	11	generally	generally	RB
cord-281188-0cql96hu	257	12	weaker	weak	JJR
cord-281188-0cql96hu	257	13	than	than	IN
cord-281188-0cql96hu	257	14	that	that	DT
cord-281188-0cql96hu	257	15	of	of	IN
cord-281188-0cql96hu	257	16	most	most	JJS
cord-281188-0cql96hu	257	17	β	β	NNP
cord-281188-0cql96hu	257	18	-	-	HYPH
cord-281188-0cql96hu	257	19	lactams	lactam	NNS
cord-281188-0cql96hu	257	20	129	129	CD
cord-281188-0cql96hu	257	21	.	.	.
cord-281188-0cql96hu	258	1	This	this	DT
cord-281188-0cql96hu	258	2	difference	difference	NN
cord-281188-0cql96hu	258	3	can	can	MD
cord-281188-0cql96hu	258	4	be	be	VB
cord-281188-0cql96hu	258	5	explained	explain	VBN
cord-281188-0cql96hu	258	6	by	by	IN
cord-281188-0cql96hu	258	7	the	the	DT
cord-281188-0cql96hu	258	8	huge	huge	JJ
cord-281188-0cql96hu	258	9	size	size	NN
cord-281188-0cql96hu	258	10	of	of	IN
cord-281188-0cql96hu	258	11	vancomycin	vancomycin	NN
cord-281188-0cql96hu	258	12	(	(	-LRB-
cord-281188-0cql96hu	258	13	1,450	1,450	CD
cord-281188-0cql96hu	258	14	Da	Da	NNS
cord-281188-0cql96hu	258	15	)	)	-RRB-
cord-281188-0cql96hu	258	16	compared	compare	VBN
cord-281188-0cql96hu	258	17	with	with	IN
cord-281188-0cql96hu	258	18	oxacillin	oxacillin	NN
cord-281188-0cql96hu	258	19	(	(	-LRB-
cord-281188-0cql96hu	258	20	401	401	CD
cord-281188-0cql96hu	258	21	Da	Da	NNP
cord-281188-0cql96hu	258	22	)	)	-RRB-
cord-281188-0cql96hu	258	23	,	,	,
cord-281188-0cql96hu	258	24	which	which	WDT
cord-281188-0cql96hu	258	25	impedes	impede	VBZ
cord-281188-0cql96hu	258	26	diffusion	diffusion	NN
cord-281188-0cql96hu	258	27	through	through	IN
cord-281188-0cql96hu	258	28	the	the	DT
cord-281188-0cql96hu	258	29	cell	cell	NN
cord-281188-0cql96hu	258	30	wall	wall	NN
cord-281188-0cql96hu	258	31	,	,	,
cord-281188-0cql96hu	258	32	which	which	WDT
cord-281188-0cql96hu	258	33	is	be	VBZ
cord-281188-0cql96hu	258	34	also	also	RB
cord-281188-0cql96hu	258	35	supported	support	VBN
cord-281188-0cql96hu	258	36	by	by	IN
cord-281188-0cql96hu	258	37	the	the	DT
cord-281188-0cql96hu	258	38	finding	finding	NN
cord-281188-0cql96hu	258	39	that	that	IN
cord-281188-0cql96hu	258	40	thicker	thick	JJR
cord-281188-0cql96hu	258	41	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	258	42	reduces	reduce	VBZ
cord-281188-0cql96hu	258	43	the	the	DT
cord-281188-0cql96hu	258	44	effect	effect	NN
cord-281188-0cql96hu	258	45	of	of	IN
cord-281188-0cql96hu	258	46	vancomycin	vancomycin	NNP
cord-281188-0cql96hu	258	47	130	130	CD
cord-281188-0cql96hu	258	48	.	.	.
cord-281188-0cql96hu	259	1	Consistently	consistently	RB
cord-281188-0cql96hu	259	2	,	,	,
cord-281188-0cql96hu	259	3	time	time	NN
cord-281188-0cql96hu	259	4	-	-	HYPH
cord-281188-0cql96hu	259	5	kill	kill	NN
cord-281188-0cql96hu	259	6	curves	curve	NNS
cord-281188-0cql96hu	259	7	show	show	VBP
cord-281188-0cql96hu	259	8	that	that	IN
cord-281188-0cql96hu	259	9	varying	vary	VBG
cord-281188-0cql96hu	259	10	the	the	DT
cord-281188-0cql96hu	259	11	concentration	concentration	NN
cord-281188-0cql96hu	259	12	of	of	IN
cord-281188-0cql96hu	259	13	vancomycin	vancomycin	NN
cord-281188-0cql96hu	259	14	has	have	VBZ
cord-281188-0cql96hu	259	15	no	no	DT
cord-281188-0cql96hu	259	16	effect	effect	NN
cord-281188-0cql96hu	259	17	on	on	IN
cord-281188-0cql96hu	259	18	the	the	DT
cord-281188-0cql96hu	259	19	rate	rate	NN
cord-281188-0cql96hu	259	20	or	or	CC
cord-281188-0cql96hu	259	21	extent	extent	NN
cord-281188-0cql96hu	259	22	of	of	IN
cord-281188-0cql96hu	259	23	bacterial	bacterial	JJ
cord-281188-0cql96hu	259	24	killing	kill	VBG
cord-281188-0cql96hu	259	25	131	131	CD
cord-281188-0cql96hu	259	26	,	,	,
cord-281188-0cql96hu	259	27	probably	probably	RB
cord-281188-0cql96hu	259	28	owing	owe	VBG
cord-281188-0cql96hu	259	29	to	to	IN
cord-281188-0cql96hu	259	30	vancomycin	vancomycin	NN
cord-281188-0cql96hu	259	31	clogging	clogging	NN
cord-281188-0cql96hu	259	32	in	in	IN
cord-281188-0cql96hu	259	33	the	the	DT
cord-281188-0cql96hu	259	34	cell	cell	NN
cord-281188-0cql96hu	259	35	wall	wall	NN
cord-281188-0cql96hu	259	36	.	.	.
cord-281188-0cql96hu	260	1	Independently	independently	RB
cord-281188-0cql96hu	260	2	from	from	IN
cord-281188-0cql96hu	260	3	the	the	DT
cord-281188-0cql96hu	260	4	membrane	membrane	NN
cord-281188-0cql96hu	260	5	-	-	HYPH
cord-281188-0cql96hu	260	6	cell	cell	NN
cord-281188-0cql96hu	260	7	wall	wall	NN
cord-281188-0cql96hu	260	8	shearing	shearing	NN
cord-281188-0cql96hu	260	9	effect	effect	NN
cord-281188-0cql96hu	260	10	(	(	-LRB-
cord-281188-0cql96hu	260	11	see	see	VB
cord-281188-0cql96hu	260	12	the	the	DT
cord-281188-0cql96hu	260	13	section	section	NN
cord-281188-0cql96hu	260	14	"	"	``
cord-281188-0cql96hu	260	15	β	β	NNP
cord-281188-0cql96hu	260	16	-	-	HYPH
cord-281188-0cql96hu	260	17	Lactam	Lactam	NNP
cord-281188-0cql96hu	260	18	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	260	19	"	"	''
cord-281188-0cql96hu	260	20	)	)	-RRB-
cord-281188-0cql96hu	260	21	,	,	,
cord-281188-0cql96hu	260	22	direct	direct	JJ
cord-281188-0cql96hu	260	23	membrane	membrane	NN
cord-281188-0cql96hu	260	24	damage	damage	NN
cord-281188-0cql96hu	260	25	can	can	MD
cord-281188-0cql96hu	260	26	probably	probably	RB
cord-281188-0cql96hu	260	27	be	be	VB
cord-281188-0cql96hu	260	28	excluded	exclude	VBN
cord-281188-0cql96hu	260	29	,	,	,
cord-281188-0cql96hu	260	30	as	as	IN
cord-281188-0cql96hu	260	31	vancomycin	vancomycin	NN
cord-281188-0cql96hu	260	32	does	do	VBZ
cord-281188-0cql96hu	260	33	not	not	RB
cord-281188-0cql96hu	260	34	act	act	VB
cord-281188-0cql96hu	260	35	on	on	IN
cord-281188-0cql96hu	260	36	protoplasts	protoplast	NNS
cord-281188-0cql96hu	260	37	or	or	CC
cord-281188-0cql96hu	260	38	Mycoplasma	Mycoplasma	NNP
cord-281188-0cql96hu	260	39	spp	spp	NNS
cord-281188-0cql96hu	260	40	.	.	.
cord-281188-0cql96hu	261	1	,	,	,
cord-281188-0cql96hu	261	2	both	both	DT
cord-281188-0cql96hu	261	3	of	of	IN
cord-281188-0cql96hu	261	4	which	which	WDT
cord-281188-0cql96hu	261	5	have	have	VBP
cord-281188-0cql96hu	261	6	no	no	DT
cord-281188-0cql96hu	261	7	cell	cell	NN
cord-281188-0cql96hu	261	8	wall	wall	NN
cord-281188-0cql96hu	261	9	.	.	.
cord-281188-0cql96hu	262	1	Superoxide	superoxide	NN
cord-281188-0cql96hu	262	2	anions	anion	NNS
cord-281188-0cql96hu	262	3	might	may	MD
cord-281188-0cql96hu	262	4	also	also	RB
cord-281188-0cql96hu	262	5	be	be	VB
cord-281188-0cql96hu	262	6	involved	involve	VBN
cord-281188-0cql96hu	262	7	in	in	IN
cord-281188-0cql96hu	262	8	the	the	DT
cord-281188-0cql96hu	262	9	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	262	10	activity	activity	NN
cord-281188-0cql96hu	262	11	of	of	IN
cord-281188-0cql96hu	262	12	vancomycin	vancomycin	NN
cord-281188-0cql96hu	262	13	in	in	IN
cord-281188-0cql96hu	262	14	Enterococcus	Enterococcus	NNP
cord-281188-0cql96hu	262	15	spp	spp	NNS
cord-281188-0cql96hu	262	16	.	.	.
cord-281188-0cql96hu	263	1	and	and	CC
cord-281188-0cql96hu	263	2	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	263	3	spp	spp	NNS
cord-281188-0cql96hu	263	4	.	.	.
cord-281188-0cql96hu	264	1	132	132	CD
cord-281188-0cql96hu	264	2	.	.	.
cord-281188-0cql96hu	265	1	Sulfonamides	sulfonamide	NNS
cord-281188-0cql96hu	265	2	and	and	CC
cord-281188-0cql96hu	265	3	trimethoprim	trimethoprim	NNS
cord-281188-0cql96hu	265	4	are	be	VBP
cord-281188-0cql96hu	265	5	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	265	6	,	,	,
cord-281188-0cql96hu	265	7	but	but	CC
cord-281188-0cql96hu	265	8	the	the	DT
cord-281188-0cql96hu	265	9	combination	combination	NN
cord-281188-0cql96hu	265	10	is	be	VBZ
cord-281188-0cql96hu	265	11	synergistic	synergistic	JJ
cord-281188-0cql96hu	265	12	,	,	,
cord-281188-0cql96hu	265	13	and	and	CC
cord-281188-0cql96hu	265	14	has	have	VBZ
cord-281188-0cql96hu	265	15	a	a	DT
cord-281188-0cql96hu	265	16	strongly	strongly	RB
cord-281188-0cql96hu	265	17	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	265	18	effect	effect	NN
cord-281188-0cql96hu	265	19	133	133	CD
cord-281188-0cql96hu	265	20	.	.	.
cord-281188-0cql96hu	266	1	The	the	DT
cord-281188-0cql96hu	266	2	two	two	CD
cord-281188-0cql96hu	266	3	drugs	drug	NNS
cord-281188-0cql96hu	266	4	inhibit	inhibit	VBP
cord-281188-0cql96hu	266	5	two	two	CD
cord-281188-0cql96hu	266	6	sequential	sequential	JJ
cord-281188-0cql96hu	266	7	steps	step	NNS
cord-281188-0cql96hu	266	8	in	in	IN
cord-281188-0cql96hu	266	9	tetrahydrofolate	tetrahydrofolate	NN
cord-281188-0cql96hu	266	10	synthesis	synthesis	NN
cord-281188-0cql96hu	266	11	(	(	-LRB-
cord-281188-0cql96hu	266	12	required	require	VBN
cord-281188-0cql96hu	266	13	for	for	IN
cord-281188-0cql96hu	266	14	nucleotide	nucleotide	JJ
cord-281188-0cql96hu	266	15	synthesis	synthesis	NN
cord-281188-0cql96hu	266	16	)	)	-RRB-
cord-281188-0cql96hu	266	17	,	,	,
cord-281188-0cql96hu	266	18	but	but	CC
cord-281188-0cql96hu	266	19	this	this	DT
cord-281188-0cql96hu	266	20	can	can	MD
cord-281188-0cql96hu	266	21	not	not	RB
cord-281188-0cql96hu	266	22	explain	explain	VB
cord-281188-0cql96hu	266	23	the	the	DT
cord-281188-0cql96hu	266	24	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	266	25	synergism	synergism	NN
cord-281188-0cql96hu	266	26	.	.	.
cord-281188-0cql96hu	267	1	The	the	DT
cord-281188-0cql96hu	267	2	synergy	synergy	NN
cord-281188-0cql96hu	267	3	is	be	VBZ
cord-281188-0cql96hu	267	4	more	more	RBR
cord-281188-0cql96hu	267	5	likely	likely	JJ
cord-281188-0cql96hu	267	6	due	due	IN
cord-281188-0cql96hu	267	7	to	to	IN
cord-281188-0cql96hu	267	8	the	the	DT
cord-281188-0cql96hu	267	9	disruption	disruption	NN
cord-281188-0cql96hu	267	10	of	of	IN
cord-281188-0cql96hu	267	11	a	a	DT
cord-281188-0cql96hu	267	12	previously	previously	RB
cord-281188-0cql96hu	267	13	unrecognized	unrecognized	JJ
cord-281188-0cql96hu	267	14	metabolic	metabolic	JJ
cord-281188-0cql96hu	267	15	feedback	feedback	NN
cord-281188-0cql96hu	267	16	loop	loop	NN
cord-281188-0cql96hu	267	17	by	by	IN
cord-281188-0cql96hu	267	18	trimethoprim	trimethoprim	NNP
cord-281188-0cql96hu	267	19	,	,	,
cord-281188-0cql96hu	267	20	which	which	WDT
cord-281188-0cql96hu	267	21	results	result	VBZ
cord-281188-0cql96hu	267	22	in	in	IN
cord-281188-0cql96hu	267	23	cyclic	cyclic	JJ
cord-281188-0cql96hu	267	24	mutual	mutual	JJ
cord-281188-0cql96hu	267	25	potentiation	potentiation	NN
cord-281188-0cql96hu	267	26	of	of	IN
cord-281188-0cql96hu	267	27	the	the	DT
cord-281188-0cql96hu	267	28	effects	effect	NNS
cord-281188-0cql96hu	267	29	of	of	IN
cord-281188-0cql96hu	267	30	the	the	DT
cord-281188-0cql96hu	267	31	two	two	CD
cord-281188-0cql96hu	267	32	drugs	drug	NNS
cord-281188-0cql96hu	267	33	,	,	,
cord-281188-0cql96hu	267	34	leading	lead	VBG
cord-281188-0cql96hu	267	35	to	to	IN
cord-281188-0cql96hu	267	36	amplified	amplify	VBN
cord-281188-0cql96hu	267	37	depletion	depletion	NN
cord-281188-0cql96hu	267	38	of	of	IN
cord-281188-0cql96hu	267	39	tetrahydrofolate	tetrahydrofolate	NN
cord-281188-0cql96hu	267	40	,	,	,
cord-281188-0cql96hu	267	41	an	an	DT
cord-281188-0cql96hu	267	42	essential	essential	JJ
cord-281188-0cql96hu	267	43	cofactor	cofactor	NN
cord-281188-0cql96hu	267	44	in	in	IN
cord-281188-0cql96hu	267	45	the	the	DT
cord-281188-0cql96hu	267	46	biosynthesis	biosynthesis	NN
cord-281188-0cql96hu	267	47	of	of	IN
cord-281188-0cql96hu	267	48	thymine	thymine	NN
cord-281188-0cql96hu	267	49	127	127	CD
cord-281188-0cql96hu	267	50	,	,	,
cord-281188-0cql96hu	267	51	134	134	CD
cord-281188-0cql96hu	267	52	.	.	.
cord-281188-0cql96hu	268	1	However	however	RB
cord-281188-0cql96hu	268	2	,	,	,
cord-281188-0cql96hu	268	3	the	the	DT
cord-281188-0cql96hu	268	4	ultimate	ultimate	JJ
cord-281188-0cql96hu	268	5	mechanism	mechanism	NN
cord-281188-0cql96hu	268	6	of	of	IN
cord-281188-0cql96hu	268	7	killing	kill	VBG
cord-281188-0cql96hu	268	8	by	by	IN
cord-281188-0cql96hu	268	9	thymine	thymine	NN
cord-281188-0cql96hu	268	10	deficiency	deficiency	NN
cord-281188-0cql96hu	268	11	(	(	-LRB-
cord-281188-0cql96hu	268	12	the	the	DT
cord-281188-0cql96hu	268	13	classic	classic	JJ
cord-281188-0cql96hu	268	14	'	'	``
cord-281188-0cql96hu	268	15	thymineless	thymineless	NN
cord-281188-0cql96hu	268	16	killing	killing	NN
cord-281188-0cql96hu	268	17	'	'	''
cord-281188-0cql96hu	268	18	)	)	-RRB-
cord-281188-0cql96hu	268	19	remains	remain	VBZ
cord-281188-0cql96hu	268	20	elusive	elusive	JJ
cord-281188-0cql96hu	268	21	;	;	:
cord-281188-0cql96hu	268	22	the	the	DT
cord-281188-0cql96hu	268	23	deprivation	deprivation	NN
cord-281188-0cql96hu	268	24	of	of	IN
cord-281188-0cql96hu	268	25	nutritional	nutritional	JJ
cord-281188-0cql96hu	268	26	requirements	requirement	NNS
cord-281188-0cql96hu	268	27	normally	normally	RB
cord-281188-0cql96hu	268	28	has	have	VBZ
cord-281188-0cql96hu	268	29	a	a	DT
cord-281188-0cql96hu	268	30	biostatic	biostatic	NN
cord-281188-0cql96hu	268	31	,	,	,
cord-281188-0cql96hu	268	32	but	but	CC
cord-281188-0cql96hu	268	33	not	not	RB
cord-281188-0cql96hu	268	34	lethal	lethal	JJ
cord-281188-0cql96hu	268	35	,	,	,
cord-281188-0cql96hu	268	36	effect	effect	NN
cord-281188-0cql96hu	268	37	135	135	CD
cord-281188-0cql96hu	268	38	,	,	,
cord-281188-0cql96hu	268	39	136	136	CD
cord-281188-0cql96hu	268	40	.	.	.
cord-281188-0cql96hu	269	1	Most	most	RBS
cord-281188-0cql96hu	269	2	probably	probably	RB
cord-281188-0cql96hu	269	3	,	,	,
cord-281188-0cql96hu	269	4	thymine	thymine	JJ
cord-281188-0cql96hu	269	5	starvation	starvation	NN
cord-281188-0cql96hu	269	6	promotes	promote	VBZ
cord-281188-0cql96hu	269	7	cell	cell	NN
cord-281188-0cql96hu	269	8	killing	killing	NN
cord-281188-0cql96hu	269	9	by	by	IN
cord-281188-0cql96hu	269	10	ROS	ROS	NNP
cord-281188-0cql96hu	269	11	-	-	HYPH
cord-281188-0cql96hu	269	12	mediated	mediate	VBN
cord-281188-0cql96hu	269	13	DNA	dna	NN
cord-281188-0cql96hu	269	14	damage	damage	NN
cord-281188-0cql96hu	269	15	34	34	CD
cord-281188-0cql96hu	269	16	.	.	.
cord-281188-0cql96hu	270	1	Surely	surely	RB
cord-281188-0cql96hu	270	2	,	,	,
cord-281188-0cql96hu	270	3	we	-PRON-	PRP
cord-281188-0cql96hu	270	4	would	would	MD
cord-281188-0cql96hu	270	5	all	all	RB
cord-281188-0cql96hu	270	6	love	love	VB
cord-281188-0cql96hu	270	7	to	to	TO
cord-281188-0cql96hu	270	8	have	have	VB
cord-281188-0cql96hu	270	9	a	a	DT
cord-281188-0cql96hu	270	10	unique	unique	JJ
cord-281188-0cql96hu	270	11	,	,	,
cord-281188-0cql96hu	270	12	broadly	broadly	RB
cord-281188-0cql96hu	270	13	supported	support	VBN
cord-281188-0cql96hu	270	14	hypothesis	hypothesis	NN
cord-281188-0cql96hu	270	15	for	for	IN
cord-281188-0cql96hu	270	16	how	how	WRB
cord-281188-0cql96hu	270	17	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	270	18	kill	kill	VBP
cord-281188-0cql96hu	270	19	bacteria	bacteria	NNS
cord-281188-0cql96hu	270	20	;	;	:
cord-281188-0cql96hu	270	21	this	this	DT
cord-281188-0cql96hu	270	22	is	be	VBZ
cord-281188-0cql96hu	270	23	particularly	particularly	RB
cord-281188-0cql96hu	270	24	so	so	RB
cord-281188-0cql96hu	270	25	if	if	IN
cord-281188-0cql96hu	270	26	we	-PRON-	PRP
cord-281188-0cql96hu	270	27	were	be	VBD
cord-281188-0cql96hu	270	28	the	the	DT
cord-281188-0cql96hu	270	29	investigators	investigator	NNS
cord-281188-0cql96hu	270	30	responsible	responsible	JJ
cord-281188-0cql96hu	270	31	for	for	IN
cord-281188-0cql96hu	270	32	providing	provide	VBG
cord-281188-0cql96hu	270	33	that	that	DT
cord-281188-0cql96hu	270	34	hypothesis	hypothesis	NN
cord-281188-0cql96hu	270	35	.	.	.
cord-281188-0cql96hu	271	1	This	this	DT
cord-281188-0cql96hu	271	2	is	be	VBZ
cord-281188-0cql96hu	271	3	not	not	RB
cord-281188-0cql96hu	271	4	the	the	DT
cord-281188-0cql96hu	271	5	case	case	NN
cord-281188-0cql96hu	271	6	;	;	:
cord-281188-0cql96hu	271	7	there	there	EX
cord-281188-0cql96hu	271	8	is	be	VBZ
cord-281188-0cql96hu	271	9	no	no	DT
cord-281188-0cql96hu	271	10	a	a	FW
cord-281188-0cql96hu	271	11	priori	priori	JJ
cord-281188-0cql96hu	271	12	reason	reason	NN
cord-281188-0cql96hu	271	13	to	to	TO
cord-281188-0cql96hu	271	14	expect	expect	VB
cord-281188-0cql96hu	271	15	that	that	IN
cord-281188-0cql96hu	271	16	the	the	DT
cord-281188-0cql96hu	271	17	same	same	JJ
cord-281188-0cql96hu	271	18	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	271	19	targeting	target	VBG
cord-281188-0cql96hu	271	20	different	different	JJ
cord-281188-0cql96hu	271	21	species	specie	NNS
cord-281188-0cql96hu	271	22	of	of	IN
cord-281188-0cql96hu	271	23	susceptible	susceptible	JJ
cord-281188-0cql96hu	271	24	bacteria	bacteria	NNS
cord-281188-0cql96hu	271	25	would	would	MD
cord-281188-0cql96hu	271	26	reach	reach	VB
cord-281188-0cql96hu	271	27	these	these	DT
cord-281188-0cql96hu	271	28	ultimate	ultimate	JJ
cord-281188-0cql96hu	271	29	(	(	-LRB-
cord-281188-0cql96hu	271	30	killing	kill	VBG
cord-281188-0cql96hu	271	31	)	)	-RRB-
cord-281188-0cql96hu	271	32	effects	effect	NNS
cord-281188-0cql96hu	271	33	by	by	IN
cord-281188-0cql96hu	271	34	the	the	DT
cord-281188-0cql96hu	271	35	same	same	JJ
cord-281188-0cql96hu	271	36	processes	process	NNS
cord-281188-0cql96hu	271	37	under	under	IN
cord-281188-0cql96hu	271	38	different	different	JJ
cord-281188-0cql96hu	271	39	growth	growth	NN
cord-281188-0cql96hu	271	40	conditions	condition	NNS
cord-281188-0cql96hu	271	41	.	.	.
cord-281188-0cql96hu	272	1	On	on	IN
cord-281188-0cql96hu	272	2	the	the	DT
cord-281188-0cql96hu	272	3	other	other	JJ
cord-281188-0cql96hu	272	4	,	,	,
cord-281188-0cql96hu	272	5	more	more	RBR
cord-281188-0cql96hu	272	6	positive	positive	JJ
cord-281188-0cql96hu	272	7	,	,	,
cord-281188-0cql96hu	272	8	side	side	NN
cord-281188-0cql96hu	272	9	,	,	,
cord-281188-0cql96hu	272	10	this	this	DT
cord-281188-0cql96hu	272	11	Perspective	perspective	NN
cord-281188-0cql96hu	272	12	suggests	suggest	VBZ
cord-281188-0cql96hu	272	13	that	that	IN
cord-281188-0cql96hu	272	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	272	15	with	with	IN
cord-281188-0cql96hu	272	16	markedly	markedly	RB
cord-281188-0cql96hu	272	17	different	different	JJ
cord-281188-0cql96hu	272	18	structures	structure	NNS
cord-281188-0cql96hu	272	19	,	,	,
cord-281188-0cql96hu	272	20	targets	target	NNS
cord-281188-0cql96hu	272	21	and	and	CC
cord-281188-0cql96hu	272	22	effects	effect	NNS
cord-281188-0cql96hu	272	23	on	on	IN
cord-281188-0cql96hu	272	24	the	the	DT
cord-281188-0cql96hu	272	25	structure	structure	NN
cord-281188-0cql96hu	272	26	and	and	CC
cord-281188-0cql96hu	272	27	physiology	physiology	NN
cord-281188-0cql96hu	272	28	of	of	IN
cord-281188-0cql96hu	272	29	bacteria	bacteria	NNS
cord-281188-0cql96hu	272	30	have	have	VBP
cord-281188-0cql96hu	272	31	proximate	proximate	JJ
cord-281188-0cql96hu	272	32	mechanisms	mechanism	NNS
cord-281188-0cql96hu	272	33	of	of	IN
cord-281188-0cql96hu	272	34	action	action	NN
cord-281188-0cql96hu	272	35	that	that	WDT
cord-281188-0cql96hu	272	36	converge	converge	VBP
cord-281188-0cql96hu	272	37	through	through	IN
cord-281188-0cql96hu	272	38	different	different	JJ
cord-281188-0cql96hu	272	39	processes	process	NNS
cord-281188-0cql96hu	272	40	in	in	IN
cord-281188-0cql96hu	272	41	the	the	DT
cord-281188-0cql96hu	272	42	death	death	NN
cord-281188-0cql96hu	272	43	of	of	IN
cord-281188-0cql96hu	272	44	bacteria	bacteria	NNS
cord-281188-0cql96hu	272	45	by	by	IN
cord-281188-0cql96hu	272	46	physical	physical	JJ
cord-281188-0cql96hu	272	47	or	or	CC
cord-281188-0cql96hu	272	48	genetic	genetic	JJ
cord-281188-0cql96hu	272	49	destructuring	destructuring	NN
cord-281188-0cql96hu	272	50	,	,	,
cord-281188-0cql96hu	272	51	the	the	DT
cord-281188-0cql96hu	272	52	ultimate	ultimate	JJ
cord-281188-0cql96hu	272	53	effects	effect	NNS
cord-281188-0cql96hu	272	54	(	(	-LRB-
cord-281188-0cql96hu	272	55	fig	fig	NN
cord-281188-0cql96hu	272	56	.	.	.
cord-281188-0cql96hu	272	57	3	3	CD
cord-281188-0cql96hu	272	58	)	)	-RRB-
cord-281188-0cql96hu	272	59	.	.	.
cord-281188-0cql96hu	273	1	Moreover	moreover	RB
cord-281188-0cql96hu	273	2	,	,	,
cord-281188-0cql96hu	273	3	we	-PRON-	PRP
cord-281188-0cql96hu	273	4	believe	believe	VBP
cord-281188-0cql96hu	273	5	that	that	IN
cord-281188-0cql96hu	273	6	the	the	DT
cord-281188-0cql96hu	273	7	links	link	NNS
cord-281188-0cql96hu	273	8	between	between	IN
cord-281188-0cql96hu	273	9	proximate	proximate	JJ
cord-281188-0cql96hu	273	10	and	and	CC
cord-281188-0cql96hu	273	11	ultimate	ultimate	JJ
cord-281188-0cql96hu	273	12	mechanisms	mechanism	NNS
cord-281188-0cql96hu	273	13	of	of	IN
cord-281188-0cql96hu	273	14	the	the	DT
cord-281188-0cql96hu	273	15	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	273	16	and	and	CC
cord-281188-0cql96hu	273	17	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	273	18	actions	action	NNS
cord-281188-0cql96hu	273	19	can	can	MD
cord-281188-0cql96hu	273	20	be	be	VB
cord-281188-0cql96hu	273	21	elucidated	elucidate	VBN
cord-281188-0cql96hu	273	22	for	for	IN
cord-281188-0cql96hu	273	23	specific	specific	JJ
cord-281188-0cql96hu	273	24	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	273	25	and	and	CC
cord-281188-0cql96hu	273	26	different	different	JJ
cord-281188-0cql96hu	273	27	species	specie	NNS
cord-281188-0cql96hu	273	28	of	of	IN
cord-281188-0cql96hu	273	29	bacteria	bacteria	NNS
cord-281188-0cql96hu	273	30	under	under	IN
cord-281188-0cql96hu	273	31	different	different	JJ
cord-281188-0cql96hu	273	32	growth	growth	NN
cord-281188-0cql96hu	273	33	conditions	condition	NNS
cord-281188-0cql96hu	273	34	.	.	.
cord-281188-0cql96hu	274	1	A	a	DT
cord-281188-0cql96hu	274	2	multifactorial	multifactorial	JJ
cord-281188-0cql96hu	274	3	perspective	perspective	NN
cord-281188-0cql96hu	274	4	of	of	IN
cord-281188-0cql96hu	274	5	bacterial	bacterial	JJ
cord-281188-0cql96hu	274	6	killing	killing	NN
cord-281188-0cql96hu	274	7	will	will	MD
cord-281188-0cql96hu	274	8	be	be	VB
cord-281188-0cql96hu	274	9	needed	need	VBN
cord-281188-0cql96hu	274	10	to	to	TO
cord-281188-0cql96hu	274	11	fully	fully	RB
cord-281188-0cql96hu	274	12	understand	understand	VB
cord-281188-0cql96hu	274	13	how	how	WRB
cord-281188-0cql96hu	274	14	the	the	DT
cord-281188-0cql96hu	274	15	effects	effect	NNS
cord-281188-0cql96hu	274	16	of	of	IN
cord-281188-0cql96hu	274	17	the	the	DT
cord-281188-0cql96hu	274	18	primary	primary	JJ
cord-281188-0cql96hu	274	19	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	274	20	action	action	NN
cord-281188-0cql96hu	274	21	on	on	IN
cord-281188-0cql96hu	274	22	targets	target	NNS
cord-281188-0cql96hu	274	23	can	can	MD
cord-281188-0cql96hu	274	24	be	be	VB
cord-281188-0cql96hu	274	25	modulated	modulate	VBN
cord-281188-0cql96hu	274	26	,	,	,
cord-281188-0cql96hu	274	27	and	and	CC
cord-281188-0cql96hu	274	28	eventually	eventually	RB
cord-281188-0cql96hu	274	29	amplified	amplify	VBN
cord-281188-0cql96hu	274	30	,	,	,
cord-281188-0cql96hu	274	31	in	in	IN
cord-281188-0cql96hu	274	32	the	the	DT
cord-281188-0cql96hu	274	33	context	context	NN
cord-281188-0cql96hu	274	34	of	of	IN
cord-281188-0cql96hu	274	35	complex	complex	JJ
cord-281188-0cql96hu	274	36	interactions	interaction	NNS
cord-281188-0cql96hu	274	37	and	and	CC
cord-281188-0cql96hu	274	38	changes	change	NNS
cord-281188-0cql96hu	274	39	of	of	IN
cord-281188-0cql96hu	274	40	cell	cell	NN
cord-281188-0cql96hu	274	41	metabolism	metabolism	NN
cord-281188-0cql96hu	274	42	,	,	,
cord-281188-0cql96hu	274	43	and	and	CC
cord-281188-0cql96hu	274	44	general	general	JJ
cord-281188-0cql96hu	274	45	cellular	cellular	JJ
cord-281188-0cql96hu	274	46	responses	response	NNS
cord-281188-0cql96hu	274	47	,	,	,
cord-281188-0cql96hu	274	48	including	include	VBG
cord-281188-0cql96hu	274	49	ROS	ROS	NNP
cord-281188-0cql96hu	274	50	production	production	NN
cord-281188-0cql96hu	274	51	,	,	,
cord-281188-0cql96hu	274	52	SOS	SOS	NNP
cord-281188-0cql96hu	274	53	induction	induction	NN
cord-281188-0cql96hu	274	54	and	and	CC
cord-281188-0cql96hu	274	55	RpoS	RpoS	NNP
cord-281188-0cql96hu	274	56	regulatory	regulatory	JJ
cord-281188-0cql96hu	274	57	effects	effect	NNS
cord-281188-0cql96hu	274	58	.	.	.
cord-281188-0cql96hu	275	1	Certainly	certainly	RB
cord-281188-0cql96hu	275	2	many	many	JJ
cord-281188-0cql96hu	275	3	of	of	IN
cord-281188-0cql96hu	275	4	these	these	DT
cord-281188-0cql96hu	275	5	responses	response	NNS
cord-281188-0cql96hu	275	6	are	be	VBP
cord-281188-0cql96hu	275	7	sensitive	sensitive	JJ
cord-281188-0cql96hu	275	8	to	to	IN
cord-281188-0cql96hu	275	9	the	the	DT
cord-281188-0cql96hu	275	10	environment	environment	NN
cord-281188-0cql96hu	275	11	,	,	,
cord-281188-0cql96hu	275	12	and	and	CC
cord-281188-0cql96hu	275	13	therefore	therefore	RB
cord-281188-0cql96hu	275	14	the	the	DT
cord-281188-0cql96hu	275	15	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	275	16	effect	effect	NN
cord-281188-0cql96hu	275	17	is	be	VBZ
cord-281188-0cql96hu	275	18	expected	expect	VBN
cord-281188-0cql96hu	275	19	to	to	TO
cord-281188-0cql96hu	275	20	differ	differ	VB
cord-281188-0cql96hu	275	21	in	in	IN
cord-281188-0cql96hu	275	22	various	various	JJ
cord-281188-0cql96hu	275	23	circumstances	circumstance	NNS
cord-281188-0cql96hu	275	24	,	,	,
cord-281188-0cql96hu	275	25	bacterial	bacterial	JJ
cord-281188-0cql96hu	275	26	species	specie	NNS
cord-281188-0cql96hu	275	27	and	and	CC
cord-281188-0cql96hu	275	28	lifestyles	lifestyle	NNS
cord-281188-0cql96hu	275	29	.	.	.
cord-281188-0cql96hu	276	1	A	a	DT
cord-281188-0cql96hu	276	2	wide	wide	JJ
cord-281188-0cql96hu	276	3	field	field	NN
cord-281188-0cql96hu	276	4	of	of	IN
cord-281188-0cql96hu	276	5	research	research	NN
cord-281188-0cql96hu	276	6	is	be	VBZ
cord-281188-0cql96hu	276	7	being	be	VBG
cord-281188-0cql96hu	276	8	opened	open	VBN
cord-281188-0cql96hu	276	9	.	.	.
cord-281188-0cql96hu	277	1	But	but	CC
cord-281188-0cql96hu	277	2	is	be	VBZ
cord-281188-0cql96hu	277	3	it	-PRON-	PRP
cord-281188-0cql96hu	277	4	worth	worth	JJ
cord-281188-0cql96hu	277	5	the	the	DT
cord-281188-0cql96hu	277	6	effort	effort	NN
cord-281188-0cql96hu	277	7	?	?	.
cord-281188-0cql96hu	278	1	We	-PRON-	PRP
cord-281188-0cql96hu	278	2	know	know	VBP
cord-281188-0cql96hu	278	3	that	that	IN
cord-281188-0cql96hu	278	4	bacteria	bacteria	NNS
cord-281188-0cql96hu	278	5	are	be	VBP
cord-281188-0cql96hu	278	6	killed	kill	VBN
cord-281188-0cql96hu	278	7	and/or	and/or	CC
cord-281188-0cql96hu	278	8	prevented	prevent	VBN
cord-281188-0cql96hu	278	9	from	from	IN
cord-281188-0cql96hu	278	10	replicating	replicate	VBG
cord-281188-0cql96hu	278	11	when	when	WRB
cord-281188-0cql96hu	278	12	exposed	expose	VBN
cord-281188-0cql96hu	278	13	to	to	IN
cord-281188-0cql96hu	278	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	278	15	,	,	,
cord-281188-0cql96hu	278	16	and	and	CC
cord-281188-0cql96hu	278	17	we	-PRON-	PRP
cord-281188-0cql96hu	278	18	know	know	VBP
cord-281188-0cql96hu	278	19	a	a	DT
cord-281188-0cql96hu	278	20	great	great	JJ
cord-281188-0cql96hu	278	21	deal	deal	NN
cord-281188-0cql96hu	278	22	about	about	IN
cord-281188-0cql96hu	278	23	the	the	DT
cord-281188-0cql96hu	278	24	conditions	condition	NNS
cord-281188-0cql96hu	278	25	under	under	IN
cord-281188-0cql96hu	278	26	which	which	WDT
cord-281188-0cql96hu	278	27	these	these	DT
cord-281188-0cql96hu	278	28	drugs	drug	NNS
cord-281188-0cql96hu	278	29	have	have	VBP
cord-281188-0cql96hu	278	30	these	these	DT
cord-281188-0cql96hu	278	31	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	278	32	and	and	CC
cord-281188-0cql96hu	278	33	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	278	34	effects	effect	NNS
cord-281188-0cql96hu	278	35	.	.	.
cord-281188-0cql96hu	279	1	Is	be	VBZ
cord-281188-0cql96hu	279	2	this	this	DT
cord-281188-0cql96hu	279	3	information	information	NN
cord-281188-0cql96hu	279	4	,	,	,
cord-281188-0cql96hu	279	5	which	which	WDT
cord-281188-0cql96hu	279	6	is	be	VBZ
cord-281188-0cql96hu	279	7	critical	critical	JJ
cord-281188-0cql96hu	279	8	to	to	IN
cord-281188-0cql96hu	279	9	the	the	DT
cord-281188-0cql96hu	279	10	clinical	clinical	JJ
cord-281188-0cql96hu	279	11	applications	application	NNS
cord-281188-0cql96hu	279	12	of	of	IN
cord-281188-0cql96hu	279	13	these	these	DT
cord-281188-0cql96hu	279	14	drugs	drug	NNS
cord-281188-0cql96hu	279	15	,	,	,
cord-281188-0cql96hu	279	16	not	not	RB
cord-281188-0cql96hu	279	17	entirely	entirely	RB
cord-281188-0cql96hu	279	18	sufficient	sufficient	JJ
cord-281188-0cql96hu	279	19	?	?	.
cord-281188-0cql96hu	280	1	We	-PRON-	PRP
cord-281188-0cql96hu	280	2	suggest	suggest	VBP
cord-281188-0cql96hu	280	3	it	-PRON-	PRP
cord-281188-0cql96hu	280	4	is	be	VBZ
cord-281188-0cql96hu	280	5	not	not	RB
cord-281188-0cql96hu	280	6	.	.	.
cord-281188-0cql96hu	281	1	Elucidating	elucidate	VBG
cord-281188-0cql96hu	281	2	how	how	WRB
cord-281188-0cql96hu	281	3	and	and	CC
cord-281188-0cql96hu	281	4	when	when	WRB
cord-281188-0cql96hu	281	5	different	different	JJ
cord-281188-0cql96hu	281	6	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	281	7	prevent	prevent	VBP
cord-281188-0cql96hu	281	8	the	the	DT
cord-281188-0cql96hu	281	9	replication	replication	NN
cord-281188-0cql96hu	281	10	of	of	IN
cord-281188-0cql96hu	281	11	bacteria	bacteria	NNS
cord-281188-0cql96hu	281	12	and	and	CC
cord-281188-0cql96hu	281	13	kill	kill	VB
cord-281188-0cql96hu	281	14	them	-PRON-	PRP
cord-281188-0cql96hu	281	15	is	be	VBZ
cord-281188-0cql96hu	281	16	not	not	RB
cord-281188-0cql96hu	281	17	just	just	RB
cord-281188-0cql96hu	281	18	an	an	DT
cord-281188-0cql96hu	281	19	academic	academic	JJ
cord-281188-0cql96hu	281	20	exercise	exercise	NN
cord-281188-0cql96hu	281	21	.	.	.
cord-281188-0cql96hu	282	1	This	this	DT
cord-281188-0cql96hu	282	2	information	information	NN
cord-281188-0cql96hu	282	3	will	will	MD
cord-281188-0cql96hu	282	4	be	be	VB
cord-281188-0cql96hu	282	5	useful	useful	JJ
cord-281188-0cql96hu	282	6	for	for	IN
cord-281188-0cql96hu	282	7	developing	develop	VBG
cord-281188-0cql96hu	282	8	much	much	RB
cord-281188-0cql96hu	282	9	-	-	HYPH
cord-281188-0cql96hu	282	10	needed	need	VBN
cord-281188-0cql96hu	282	11	new	new	JJ
cord-281188-0cql96hu	282	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	282	13	.	.	.
cord-281188-0cql96hu	283	1	It	-PRON-	PRP
cord-281188-0cql96hu	283	2	will	will	MD
cord-281188-0cql96hu	283	3	also	also	RB
cord-281188-0cql96hu	283	4	be	be	VB
cord-281188-0cql96hu	283	5	helpful	helpful	JJ
cord-281188-0cql96hu	283	6	for	for	IN
cord-281188-0cql96hu	283	7	designing	design	VBG
cord-281188-0cql96hu	283	8	protocols	protocol	NNS
cord-281188-0cql96hu	283	9	for	for	IN
cord-281188-0cql96hu	283	10	the	the	DT
cord-281188-0cql96hu	283	11	administration	administration	NN
cord-281188-0cql96hu	283	12	of	of	IN
cord-281188-0cql96hu	283	13	existing	exist	VBG
cord-281188-0cql96hu	283	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	283	15	and	and	CC
cord-281188-0cql96hu	283	16	combinations	combination	NNS
cord-281188-0cql96hu	283	17	of	of	IN
cord-281188-0cql96hu	283	18	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	283	19	that	that	WDT
cord-281188-0cql96hu	283	20	are	be	VBP
cord-281188-0cql96hu	283	21	effective	effective	JJ
cord-281188-0cql96hu	283	22	clinically	clinically	RB
cord-281188-0cql96hu	283	23	,	,	,
cord-281188-0cql96hu	283	24	and	and	CC
cord-281188-0cql96hu	283	25	at	at	IN
cord-281188-0cql96hu	283	26	the	the	DT
cord-281188-0cql96hu	283	27	same	same	JJ
cord-281188-0cql96hu	283	28	time	time	NN
cord-281188-0cql96hu	283	29	minimize	minimize	VB
cord-281188-0cql96hu	283	30	the	the	DT
cord-281188-0cql96hu	283	31	likelihood	likelihood	NN
cord-281188-0cql96hu	283	32	of	of	IN
cord-281188-0cql96hu	283	33	emergence	emergence	NN
cord-281188-0cql96hu	283	34	and	and	CC
cord-281188-0cql96hu	283	35	rise	rise	NN
cord-281188-0cql96hu	283	36	of	of	IN
cord-281188-0cql96hu	283	37	resistance	resistance	NN
cord-281188-0cql96hu	283	38	to	to	IN
cord-281188-0cql96hu	283	39	these	these	DT
cord-281188-0cql96hu	283	40	drugs	drug	NNS
cord-281188-0cql96hu	283	41	in	in	IN
cord-281188-0cql96hu	283	42	target	target	NN
cord-281188-0cql96hu	283	43	bacteria	bacteria	NNS
cord-281188-0cql96hu	283	44	and	and	CC
cord-281188-0cql96hu	283	45	commensals	commensal	NNS
cord-281188-0cql96hu	283	46	and	and	CC
cord-281188-0cql96hu	283	47	disturbance	disturbance	NN
cord-281188-0cql96hu	283	48	of	of	IN
cord-281188-0cql96hu	283	49	the	the	DT
cord-281188-0cql96hu	283	50	microbiota	microbiota	NN
cord-281188-0cql96hu	283	51	.	.	.
cord-281188-0cql96hu	284	1	Address	address	NN
cord-281188-0cql96hu	284	2	in	in	IN
cord-281188-0cql96hu	284	3	pathology	pathology	NN
cord-281188-0cql96hu	284	4	,	,	,
cord-281188-0cql96hu	284	5	on	on	IN
cord-281188-0cql96hu	284	6	chemiotherapy	chemiotherapy	NN
cord-281188-0cql96hu	284	7	:	:	:
cord-281188-0cql96hu	284	8	delivered	deliver	VBN
cord-281188-0cql96hu	284	9	before	before	IN
cord-281188-0cql96hu	284	10	the	the	DT
cord-281188-0cql96hu	284	11	Seventeenth	Seventeenth	NNP
cord-281188-0cql96hu	284	12	International	International	NNP
cord-281188-0cql96hu	284	13	Congress	Congress	NNP
cord-281188-0cql96hu	284	14	of	of	IN
cord-281188-0cql96hu	284	15	Medicine	Medicine	NNP
cord-281188-0cql96hu	285	1	How	how	WRB
cord-281188-0cql96hu	285	2	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	285	3	kill	kill	VBP
cord-281188-0cql96hu	285	4	bacteria	bacteria	NNS
cord-281188-0cql96hu	285	5	:	:	:
cord-281188-0cql96hu	285	6	new	new	JJ
cord-281188-0cql96hu	285	7	models	model	NNS
cord-281188-0cql96hu	285	8	needed	need	VBN
cord-281188-0cql96hu	285	9	?	?	.
cord-281188-0cql96hu	286	1	A	a	DT
cord-281188-0cql96hu	286	2	numbers	number	NNS
cord-281188-0cql96hu	286	3	game	game	NN
cord-281188-0cql96hu	286	4	:	:	:
cord-281188-0cql96hu	286	5	ribosome	ribosome	NN
cord-281188-0cql96hu	286	6	densities	density	NNS
cord-281188-0cql96hu	286	7	,	,	,
cord-281188-0cql96hu	286	8	bacterial	bacterial	JJ
cord-281188-0cql96hu	286	9	growth	growth	NN
cord-281188-0cql96hu	286	10	,	,	,
cord-281188-0cql96hu	286	11	and	and	CC
cord-281188-0cql96hu	286	12	antibiotic	antibiotic	RB
cord-281188-0cql96hu	286	13	-	-	HYPH
cord-281188-0cql96hu	286	14	mediated	mediate	VBN
cord-281188-0cql96hu	286	15	stasis	stasis	NN
cord-281188-0cql96hu	286	16	and	and	CC
cord-281188-0cql96hu	286	17	death	death	NN
cord-281188-0cql96hu	286	18	Cause	cause	NN
cord-281188-0cql96hu	286	19	and	and	CC
cord-281188-0cql96hu	286	20	effect	effect	NN
cord-281188-0cql96hu	286	21	in	in	IN
cord-281188-0cql96hu	286	22	biology	biology	NN
cord-281188-0cql96hu	286	23	Cause	cause	NN
cord-281188-0cql96hu	286	24	and	and	CC
cord-281188-0cql96hu	286	25	effect	effect	NN
cord-281188-0cql96hu	286	26	in	in	IN
cord-281188-0cql96hu	286	27	biology	biology	NN
cord-281188-0cql96hu	286	28	revisited	revisit	VBN
cord-281188-0cql96hu	286	29	:	:	:
cord-281188-0cql96hu	286	30	is	be	VBZ
cord-281188-0cql96hu	286	31	Mayr	Mayr	NNP
cord-281188-0cql96hu	286	32	's	's	POS
cord-281188-0cql96hu	286	33	proximate	proximate	JJ
cord-281188-0cql96hu	286	34	-	-	HYPH
cord-281188-0cql96hu	286	35	ultimate	ultimate	JJ
cord-281188-0cql96hu	286	36	dichotomy	dichotomy	NN
cord-281188-0cql96hu	286	37	still	still	RB
cord-281188-0cql96hu	286	38	useful	useful	JJ
cord-281188-0cql96hu	286	39	?	?	.
cord-281188-0cql96hu	287	1	Ernst	Ernst	NNP
cord-281188-0cql96hu	287	2	Mayr	Mayr	NNP
cord-281188-0cql96hu	287	3	's	's	POS
cord-281188-0cql96hu	287	4	'	'	``
cord-281188-0cql96hu	287	5	ultimate	ultimate	JJ
cord-281188-0cql96hu	287	6	/	/	SYM
cord-281188-0cql96hu	287	7	proximate	proximate	JJ
cord-281188-0cql96hu	287	8	'	'	''
cord-281188-0cql96hu	287	9	distinction	distinction	NN
cord-281188-0cql96hu	287	10	reconsidered	reconsider	VBD
cord-281188-0cql96hu	287	11	and	and	CC
cord-281188-0cql96hu	287	12	reconstructed	reconstruct	VBD
cord-281188-0cql96hu	287	13	The	the	DT
cord-281188-0cql96hu	287	14	Uniqueness	uniqueness	NN
cord-281188-0cql96hu	287	15	of	of	IN
cord-281188-0cql96hu	287	16	the	the	DT
cord-281188-0cql96hu	287	17	Individual	Individual	NNP
cord-281188-0cql96hu	287	18	Mechanism	Mechanism	NNP
cord-281188-0cql96hu	287	19	of	of	IN
cord-281188-0cql96hu	287	20	disinfection	disinfection	NN
cord-281188-0cql96hu	287	21	:	:	:
cord-281188-0cql96hu	287	22	effect	effect	NN
cord-281188-0cql96hu	287	23	of	of	IN
cord-281188-0cql96hu	287	24	chlorine	chlorine	NN
cord-281188-0cql96hu	287	25	on	on	IN
cord-281188-0cql96hu	287	26	cell	cell	NN
cord-281188-0cql96hu	287	27	membrane	membrane	NN
cord-281188-0cql96hu	287	28	functions	function	NNS
cord-281188-0cql96hu	287	29	Membrane	membrane	NN
cord-281188-0cql96hu	287	30	damage	damage	NN
cord-281188-0cql96hu	287	31	and	and	CC
cord-281188-0cql96hu	287	32	microbial	microbial	JJ
cord-281188-0cql96hu	287	33	inactivation	inactivation	NN
cord-281188-0cql96hu	287	34	by	by	IN
cord-281188-0cql96hu	287	35	chlorine	chlorine	NN
cord-281188-0cql96hu	287	36	in	in	IN
cord-281188-0cql96hu	287	37	the	the	DT
cord-281188-0cql96hu	287	38	absence	absence	NN
cord-281188-0cql96hu	287	39	and	and	CC
cord-281188-0cql96hu	287	40	presence	presence	NN
cord-281188-0cql96hu	287	41	of	of	IN
cord-281188-0cql96hu	287	42	a	a	DT
cord-281188-0cql96hu	287	43	chlorinedemanding	chlorinedemanding	NN
cord-281188-0cql96hu	287	44	substrate	substrate	NN
cord-281188-0cql96hu	287	45	Pharmacodynamic	Pharmacodynamic	NNP
cord-281188-0cql96hu	287	46	functions	function	NNS
cord-281188-0cql96hu	287	47	:	:	:
cord-281188-0cql96hu	287	48	a	a	DT
cord-281188-0cql96hu	287	49	multiparameter	multiparameter	NN
cord-281188-0cql96hu	287	50	approach	approach	NN
cord-281188-0cql96hu	287	51	to	to	IN
cord-281188-0cql96hu	287	52	the	the	DT
cord-281188-0cql96hu	287	53	design	design	NN
cord-281188-0cql96hu	287	54	of	of	IN
cord-281188-0cql96hu	287	55	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	287	56	treatment	treatment	NN
cord-281188-0cql96hu	287	57	regimens	regimen	NNS
cord-281188-0cql96hu	287	58	Effects	effect	NNS
cord-281188-0cql96hu	287	59	of	of	IN
cord-281188-0cql96hu	287	60	extracts	extract	NNS
cord-281188-0cql96hu	287	61	of	of	IN
cord-281188-0cql96hu	287	62	western	western	JJ
cord-281188-0cql96hu	287	63	redcedar	redcedar	NN
cord-281188-0cql96hu	287	64	heartwood	heartwood	NN
cord-281188-0cql96hu	287	65	on	on	IN
cord-281188-0cql96hu	287	66	certain	certain	JJ
cord-281188-0cql96hu	287	67	wood	wood	NN
cord-281188-0cql96hu	287	68	-	-	HYPH
cord-281188-0cql96hu	287	69	decaying	decay	VBG
cord-281188-0cql96hu	287	70	fungi	fungus	NNS
cord-281188-0cql96hu	287	71	in	in	IN
cord-281188-0cql96hu	287	72	culture	culture	NN
cord-281188-0cql96hu	288	1	The	the	DT
cord-281188-0cql96hu	288	2	world	world	NN
cord-281188-0cql96hu	288	3	of	of	IN
cord-281188-0cql96hu	288	4	subinhibitory	subinhibitory	NNP
cord-281188-0cql96hu	288	5	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	288	6	concentrations	concentration	NNS
cord-281188-0cql96hu	288	7	Antibiotics	Antibiotics	NNP
cord-281188-0cql96hu	288	8	as	as	IN
cord-281188-0cql96hu	288	9	intermicrobial	intermicrobial	JJ
cord-281188-0cql96hu	288	10	signaling	signal	VBG
cord-281188-0cql96hu	288	11	agents	agent	NNS
cord-281188-0cql96hu	288	12	instead	instead	RB
cord-281188-0cql96hu	288	13	of	of	IN
cord-281188-0cql96hu	288	14	weapons	weapon	NNS
cord-281188-0cql96hu	289	1	Hormesis	hormesis	NN
cord-281188-0cql96hu	289	2	:	:	:
cord-281188-0cql96hu	289	3	a	a	DT
cord-281188-0cql96hu	289	4	fundamental	fundamental	JJ
cord-281188-0cql96hu	289	5	concept	concept	NN
cord-281188-0cql96hu	289	6	in	in	IN
cord-281188-0cql96hu	289	7	biology	biology	NN
cord-281188-0cql96hu	289	8	Biological	biological	JJ
cord-281188-0cql96hu	289	9	stress	stress	NN
cord-281188-0cql96hu	289	10	response	response	NN
cord-281188-0cql96hu	289	11	terminology	terminology	NN
cord-281188-0cql96hu	289	12	:	:	:
cord-281188-0cql96hu	289	13	integrating	integrate	VBG
cord-281188-0cql96hu	289	14	the	the	DT
cord-281188-0cql96hu	289	15	concepts	concept	NNS
cord-281188-0cql96hu	289	16	of	of	IN
cord-281188-0cql96hu	289	17	adaptive	adaptive	JJ
cord-281188-0cql96hu	289	18	response	response	NN
cord-281188-0cql96hu	289	19	and	and	CC
cord-281188-0cql96hu	289	20	preconditioning	preconditioning	NN
cord-281188-0cql96hu	289	21	stress	stress	NN
cord-281188-0cql96hu	289	22	within	within	IN
cord-281188-0cql96hu	289	23	a	a	DT
cord-281188-0cql96hu	289	24	hormetic	hormetic	JJ
cord-281188-0cql96hu	289	25	dose	dose	NN
cord-281188-0cql96hu	289	26	-	-	HYPH
cord-281188-0cql96hu	289	27	response	response	NN
cord-281188-0cql96hu	289	28	framework	framework	NN
cord-281188-0cql96hu	289	29	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	289	30	aureus	aureus	NN
cord-281188-0cql96hu	289	31	in	in	IN
cord-281188-0cql96hu	289	32	continuous	continuous	JJ
cord-281188-0cql96hu	289	33	culture	culture	NN
cord-281188-0cql96hu	289	34	:	:	:
cord-281188-0cql96hu	289	35	a	a	DT
cord-281188-0cql96hu	289	36	tool	tool	NN
cord-281188-0cql96hu	289	37	for	for	IN
cord-281188-0cql96hu	289	38	the	the	DT
cord-281188-0cql96hu	289	39	rational	rational	JJ
cord-281188-0cql96hu	289	40	design	design	NN
cord-281188-0cql96hu	289	41	of	of	IN
cord-281188-0cql96hu	289	42	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	289	43	treatment	treatment	NN
cord-281188-0cql96hu	289	44	protocols	protocol	NNS
cord-281188-0cql96hu	289	45	Treatment	treatment	NN
cord-281188-0cql96hu	289	46	of	of	IN
cord-281188-0cql96hu	289	47	staphylococcal	staphylococcal	JJ
cord-281188-0cql96hu	289	48	infections	infection	NNS
cord-281188-0cql96hu	289	49	with	with	IN
cord-281188-0cql96hu	289	50	penicillin	penicillin	NN
cord-281188-0cql96hu	289	51	Definitions	Definitions	NNPS
cord-281188-0cql96hu	289	52	and	and	CC
cord-281188-0cql96hu	289	53	guidelines	guideline	NNS
cord-281188-0cql96hu	289	54	for	for	IN
cord-281188-0cql96hu	289	55	research	research	NN
cord-281188-0cql96hu	289	56	on	on	IN
cord-281188-0cql96hu	289	57	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	289	58	persistence	persistence	NN
cord-281188-0cql96hu	289	59	Comparative	comparative	JJ
cord-281188-0cql96hu	289	60	effect	effect	NN
cord-281188-0cql96hu	289	61	of	of	IN
cord-281188-0cql96hu	289	62	protein	protein	NN
cord-281188-0cql96hu	289	63	binding	bind	VBG
cord-281188-0cql96hu	289	64	on	on	IN
cord-281188-0cql96hu	289	65	the	the	DT
cord-281188-0cql96hu	289	66	killing	killing	NN
cord-281188-0cql96hu	289	67	activities	activity	NNS
cord-281188-0cql96hu	289	68	of	of	IN
cord-281188-0cql96hu	289	69	teicoplanin	teicoplanin	NNS
cord-281188-0cql96hu	289	70	and	and	CC
cord-281188-0cql96hu	289	71	vancomycin	vancomycin	NNP
cord-281188-0cql96hu	290	1	The	the	DT
cord-281188-0cql96hu	290	2	porin	porin	NNS
cord-281188-0cql96hu	290	3	and	and	CC
cord-281188-0cql96hu	290	4	the	the	DT
cord-281188-0cql96hu	290	5	permeating	permeate	VBG
cord-281188-0cql96hu	290	6	antibiotic	antibiotic	NN
cord-281188-0cql96hu	290	7	:	:	:
cord-281188-0cql96hu	290	8	a	a	DT
cord-281188-0cql96hu	290	9	selective	selective	JJ
cord-281188-0cql96hu	290	10	diffusion	diffusion	NN
cord-281188-0cql96hu	290	11	barrier	barrier	NN
cord-281188-0cql96hu	290	12	in	in	IN
cord-281188-0cql96hu	290	13	Gram	gram	NN
cord-281188-0cql96hu	290	14	-	-	HYPH
cord-281188-0cql96hu	290	15	negative	negative	JJ
cord-281188-0cql96hu	290	16	bacteria	bacteria	NNS
cord-281188-0cql96hu	290	17	Multidrug	Multidrug	NNP
cord-281188-0cql96hu	290	18	efflux	efflux	NN
cord-281188-0cql96hu	290	19	pumps	pump	NNS
cord-281188-0cql96hu	290	20	of	of	IN
cord-281188-0cql96hu	290	21	gram	gram	NN
cord-281188-0cql96hu	290	22	-	-	HYPH
cord-281188-0cql96hu	290	23	negative	negative	JJ
cord-281188-0cql96hu	290	24	bacteria	bacteria	NNS
cord-281188-0cql96hu	290	25	Efflux	Efflux	NNP
cord-281188-0cql96hu	290	26	-	-	HYPH
cord-281188-0cql96hu	290	27	mediated	mediate	VBN
cord-281188-0cql96hu	290	28	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	290	29	resistance	resistance	NN
cord-281188-0cql96hu	290	30	Drug	drug	NN
cord-281188-0cql96hu	290	31	-	-	HYPH
cord-281188-0cql96hu	290	32	target	target	NN
cord-281188-0cql96hu	290	33	binding	binding	NN
cord-281188-0cql96hu	290	34	quantitatively	quantitatively	RB
cord-281188-0cql96hu	290	35	predicts	predict	VBZ
cord-281188-0cql96hu	290	36	optimal	optimal	JJ
cord-281188-0cql96hu	290	37	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	290	38	dose	dose	NN
cord-281188-0cql96hu	290	39	levels	level	NNS
cord-281188-0cql96hu	290	40	Rifampicin	Rifampicin	NNP
cord-281188-0cql96hu	290	41	can	can	MD
cord-281188-0cql96hu	290	42	induce	induce	VB
cord-281188-0cql96hu	290	43	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	290	44	tolerance	tolerance	NN
cord-281188-0cql96hu	290	45	in	in	IN
cord-281188-0cql96hu	290	46	mycobacteria	mycobacterium	NNS
cord-281188-0cql96hu	290	47	via	via	IN
cord-281188-0cql96hu	290	48	paradoxical	paradoxical	JJ
cord-281188-0cql96hu	290	49	changes	change	NNS
cord-281188-0cql96hu	290	50	in	in	IN
cord-281188-0cql96hu	290	51	rpoB	rpob	ADD
cord-281188-0cql96hu	290	52	transcription	transcription	NN
cord-281188-0cql96hu	291	1	In	in	IN
cord-281188-0cql96hu	291	2	vivo	vivo	NN
cord-281188-0cql96hu	291	3	potency	potency	NN
cord-281188-0cql96hu	291	4	revisited	revisit	VBD
cord-281188-0cql96hu	292	1	-keep	-keep	.
cord-281188-0cql96hu	293	1	the	the	DT
cord-281188-0cql96hu	293	2	target	target	NN
cord-281188-0cql96hu	293	3	in	in	IN
cord-281188-0cql96hu	293	4	sight	sight	NN
cord-281188-0cql96hu	293	5	Blocking	block	VBG
cord-281188-0cql96hu	293	6	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	293	7	recycling	recycling	NN
cord-281188-0cql96hu	293	8	in	in	IN
cord-281188-0cql96hu	293	9	pseudomonas	pseudomonas	NNP
cord-281188-0cql96hu	293	10	aeruginosa	aeruginosa	NN
cord-281188-0cql96hu	293	11	attenuates	attenuate	VBZ
cord-281188-0cql96hu	293	12	intrinsic	intrinsic	JJ
cord-281188-0cql96hu	293	13	resistance	resistance	NN
cord-281188-0cql96hu	293	14	to	to	IN
cord-281188-0cql96hu	293	15	fosfomycin	fosfomycin	NNP
cord-281188-0cql96hu	293	16	SOS	SOS	NNP
cord-281188-0cql96hu	293	17	response	response	NN
cord-281188-0cql96hu	293	18	induction	induction	NN
cord-281188-0cql96hu	293	19	by	by	IN
cord-281188-0cql96hu	293	20	betalactams	betalactam	NNS
cord-281188-0cql96hu	293	21	and	and	CC
cord-281188-0cql96hu	293	22	bacterial	bacterial	JJ
cord-281188-0cql96hu	293	23	defense	defense	NN
cord-281188-0cql96hu	293	24	against	against	IN
cord-281188-0cql96hu	293	25	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	293	26	lethality	lethality	NN
cord-281188-0cql96hu	294	1	AmpC	AmpC	NNP
cord-281188-0cql96hu	294	2	beta	beta	NN
cord-281188-0cql96hu	294	3	-	-	HYPH
cord-281188-0cql96hu	294	4	lactamases	lactamase	NNS
cord-281188-0cql96hu	294	5	Novel	Novel	NNP
cord-281188-0cql96hu	294	6	mechanism	mechanism	NN
cord-281188-0cql96hu	294	7	of	of	IN
cord-281188-0cql96hu	294	8	beta	beta	NN
cord-281188-0cql96hu	294	9	-	-	HYPH
cord-281188-0cql96hu	294	10	lactam	lactam	NN
cord-281188-0cql96hu	294	11	resistance	resistance	NN
cord-281188-0cql96hu	294	12	due	due	JJ
cord-281188-0cql96hu	294	13	to	to	IN
cord-281188-0cql96hu	294	14	bypass	bypass	NN
cord-281188-0cql96hu	294	15	of	of	IN
cord-281188-0cql96hu	294	16	DD	dd	NN
cord-281188-0cql96hu	294	17	-	-	HYPH
cord-281188-0cql96hu	294	18	transpeptidation	transpeptidation	NN
cord-281188-0cql96hu	294	19	in	in	IN
cord-281188-0cql96hu	294	20	Enterococcus	Enterococcus	NNP
cord-281188-0cql96hu	294	21	faecium	faecium	NN
cord-281188-0cql96hu	295	1	Massive	massive	JJ
cord-281188-0cql96hu	295	2	overproduction	overproduction	NN
cord-281188-0cql96hu	295	3	of	of	IN
cord-281188-0cql96hu	295	4	dihydrofolate	dihydrofolate	NN
cord-281188-0cql96hu	295	5	reductase	reductase	NN
cord-281188-0cql96hu	295	6	in	in	IN
cord-281188-0cql96hu	295	7	bacteria	bacteria	NNS
cord-281188-0cql96hu	295	8	as	as	IN
cord-281188-0cql96hu	295	9	a	a	DT
cord-281188-0cql96hu	295	10	response	response	NN
cord-281188-0cql96hu	295	11	to	to	IN
cord-281188-0cql96hu	295	12	the	the	DT
cord-281188-0cql96hu	295	13	use	use	NN
cord-281188-0cql96hu	295	14	of	of	IN
cord-281188-0cql96hu	295	15	trimethoprim	trimethoprim	NNP
cord-281188-0cql96hu	295	16	Bactericidal	Bactericidal	NNP
cord-281188-0cql96hu	295	17	activities	activity	NNS
cord-281188-0cql96hu	295	18	of	of	IN
cord-281188-0cql96hu	295	19	five	five	CD
cord-281188-0cql96hu	295	20	quinolones	quinolone	NNS
cord-281188-0cql96hu	295	21	for	for	IN
cord-281188-0cql96hu	295	22	Escherichia	escherichia	NN
cord-281188-0cql96hu	295	23	coli	coli	VBZ
cord-281188-0cql96hu	295	24	strains	strain	NNS
cord-281188-0cql96hu	295	25	with	with	IN
cord-281188-0cql96hu	295	26	mutations	mutation	NNS
cord-281188-0cql96hu	295	27	in	in	IN
cord-281188-0cql96hu	295	28	genes	gene	NNS
cord-281188-0cql96hu	295	29	encoding	encode	VBG
cord-281188-0cql96hu	295	30	the	the	DT
cord-281188-0cql96hu	295	31	SOS	SOS	NNP
cord-281188-0cql96hu	295	32	response	response	NN
cord-281188-0cql96hu	295	33	or	or	CC
cord-281188-0cql96hu	295	34	cell	cell	NN
cord-281188-0cql96hu	295	35	division	division	NN
cord-281188-0cql96hu	296	1	A	a	DT
cord-281188-0cql96hu	296	2	common	common	JJ
cord-281188-0cql96hu	296	3	mechanism	mechanism	NN
cord-281188-0cql96hu	296	4	of	of	IN
cord-281188-0cql96hu	296	5	cellular	cellular	JJ
cord-281188-0cql96hu	296	6	death	death	NN
cord-281188-0cql96hu	296	7	induced	induce	VBN
cord-281188-0cql96hu	296	8	by	by	IN
cord-281188-0cql96hu	296	9	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	296	10	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	296	11	SOS	SOS	NNP
cord-281188-0cql96hu	296	12	response	response	NN
cord-281188-0cql96hu	296	13	induces	induce	VBZ
cord-281188-0cql96hu	296	14	persistence	persistence	NN
cord-281188-0cql96hu	296	15	to	to	IN
cord-281188-0cql96hu	296	16	fluoroquinolones	fluoroquinolone	NNS
cord-281188-0cql96hu	296	17	in	in	IN
cord-281188-0cql96hu	296	18	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	296	19	coli	coli	VBZ
cord-281188-0cql96hu	296	20	Post	post	JJ
cord-281188-0cql96hu	296	21	-	-	JJ
cord-281188-0cql96hu	296	22	stress	stress	JJ
cord-281188-0cql96hu	296	23	bacterial	bacterial	JJ
cord-281188-0cql96hu	296	24	cell	cell	NN
cord-281188-0cql96hu	296	25	death	death	NN
cord-281188-0cql96hu	296	26	mediated	mediate	VBN
cord-281188-0cql96hu	296	27	by	by	IN
cord-281188-0cql96hu	296	28	reactive	reactive	JJ
cord-281188-0cql96hu	296	29	oxygen	oxygen	NN
cord-281188-0cql96hu	296	30	species	specie	NNS
cord-281188-0cql96hu	296	31	Antibiotic	antibiotic	JJ
cord-281188-0cql96hu	296	32	killing	killing	NN
cord-281188-0cql96hu	296	33	of	of	IN
cord-281188-0cql96hu	296	34	diversely	diversely	RB
cord-281188-0cql96hu	296	35	generated	generate	VBN
cord-281188-0cql96hu	296	36	populations	population	NNS
cord-281188-0cql96hu	296	37	of	of	IN
cord-281188-0cql96hu	296	38	nonreplicating	nonreplicate	VBG
cord-281188-0cql96hu	296	39	bacteria	bacteria	NNS
cord-281188-0cql96hu	296	40	For	for	IN
cord-281188-0cql96hu	296	41	the	the	DT
cord-281188-0cql96hu	296	42	greater	great	JJR
cord-281188-0cql96hu	296	43	good	good	NN
cord-281188-0cql96hu	296	44	:	:	:
cord-281188-0cql96hu	296	45	programmed	program	VBN
cord-281188-0cql96hu	296	46	cell	cell	NN
cord-281188-0cql96hu	296	47	death	death	NN
cord-281188-0cql96hu	296	48	in	in	IN
cord-281188-0cql96hu	296	49	bacterial	bacterial	JJ
cord-281188-0cql96hu	296	50	communities	community	NNS
cord-281188-0cql96hu	297	1	The	the	DT
cord-281188-0cql96hu	297	2	rate	rate	NN
cord-281188-0cql96hu	297	3	of	of	IN
cord-281188-0cql96hu	297	4	killing	killing	NN
cord-281188-0cql96hu	297	5	of	of	IN
cord-281188-0cql96hu	297	6	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	297	7	coli	coli	NNS
cord-281188-0cql96hu	297	8	by	by	IN
cord-281188-0cql96hu	297	9	beta	beta	NN
cord-281188-0cql96hu	297	10	-	-	HYPH
cord-281188-0cql96hu	297	11	lactam	lactam	NN
cord-281188-0cql96hu	297	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	297	13	is	be	VBZ
cord-281188-0cql96hu	297	14	strictly	strictly	RB
cord-281188-0cql96hu	297	15	proportional	proportional	JJ
cord-281188-0cql96hu	297	16	to	to	IN
cord-281188-0cql96hu	297	17	the	the	DT
cord-281188-0cql96hu	297	18	rate	rate	NN
cord-281188-0cql96hu	297	19	of	of	IN
cord-281188-0cql96hu	297	20	bacterial	bacterial	JJ
cord-281188-0cql96hu	297	21	growth	growth	NN
cord-281188-0cql96hu	297	22	Kinetics	kinetic	NNS
cord-281188-0cql96hu	297	23	of	of	IN
cord-281188-0cql96hu	297	24	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	297	25	activity	activity	NN
cord-281188-0cql96hu	297	26	Mechanisms	Mechanisms	NNPS
cord-281188-0cql96hu	297	27	of	of	IN
cord-281188-0cql96hu	297	28	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	297	29	action	action	NN
cord-281188-0cql96hu	297	30	of	of	IN
cord-281188-0cql96hu	297	31	antiseptics	antiseptic	NNS
cord-281188-0cql96hu	297	32	and	and	CC
cord-281188-0cql96hu	297	33	disinfectants	disinfectant	NNS
cord-281188-0cql96hu	297	34	:	:	:
cord-281188-0cql96hu	297	35	an	an	DT
cord-281188-0cql96hu	297	36	increasingly	increasingly	RB
cord-281188-0cql96hu	297	37	important	important	JJ
cord-281188-0cql96hu	297	38	area	area	NN
cord-281188-0cql96hu	297	39	of	of	IN
cord-281188-0cql96hu	297	40	investigation	investigation	NN
cord-281188-0cql96hu	297	41	Bacterial	bacterial	JJ
cord-281188-0cql96hu	297	42	target	target	NN
cord-281188-0cql96hu	297	43	sites	site	NNS
cord-281188-0cql96hu	297	44	for	for	IN
cord-281188-0cql96hu	297	45	biocide	biocide	NN
cord-281188-0cql96hu	297	46	action	action	NN
cord-281188-0cql96hu	297	47	Antibiotic	antibiotic	JJ
cord-281188-0cql96hu	297	48	combinations	combination	NNS
cord-281188-0cql96hu	297	49	:	:	:
cord-281188-0cql96hu	297	50	should	should	MD
cord-281188-0cql96hu	297	51	they	-PRON-	PRP
cord-281188-0cql96hu	297	52	be	be	VB
cord-281188-0cql96hu	297	53	tested	test	VBN
cord-281188-0cql96hu	297	54	?	?	.
cord-281188-0cql96hu	298	1	Synergy	synergy	NN
cord-281188-0cql96hu	298	2	and	and	CC
cord-281188-0cql96hu	298	3	order	order	VB
cord-281188-0cql96hu	298	4	effects	effect	NNS
cord-281188-0cql96hu	298	5	of	of	IN
cord-281188-0cql96hu	298	6	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	298	7	and	and	CC
cord-281188-0cql96hu	298	8	phages	phage	NNS
cord-281188-0cql96hu	298	9	in	in	IN
cord-281188-0cql96hu	298	10	killing	kill	VBG
cord-281188-0cql96hu	298	11	pseudomonas	pseudomonas	NN
cord-281188-0cql96hu	298	12	aeruginosa	aeruginosa	NN
cord-281188-0cql96hu	298	13	biofilms	biofilms	NNP
cord-281188-0cql96hu	298	14	Adjunct	Adjunct	NNP
cord-281188-0cql96hu	298	15	phage	phage	NN
cord-281188-0cql96hu	298	16	treatment	treatment	NN
cord-281188-0cql96hu	298	17	enhances	enhance	VBZ
cord-281188-0cql96hu	298	18	the	the	DT
cord-281188-0cql96hu	298	19	effectiveness	effectiveness	NN
cord-281188-0cql96hu	298	20	of	of	IN
cord-281188-0cql96hu	298	21	low	low	JJ
cord-281188-0cql96hu	298	22	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	298	23	concentration	concentration	NN
cord-281188-0cql96hu	298	24	against	against	IN
cord-281188-0cql96hu	298	25	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	298	26	aureus	aureus	NN
cord-281188-0cql96hu	298	27	biofilms	biofilms	VB
cord-281188-0cql96hu	298	28	in	in	IN
cord-281188-0cql96hu	298	29	vitro	vitro	FW
cord-281188-0cql96hu	298	30	Bactericidal	bactericidal	JJ
cord-281188-0cql96hu	298	31	index	index	NN
cord-281188-0cql96hu	298	32	:	:	:
cord-281188-0cql96hu	298	33	a	a	DT
cord-281188-0cql96hu	298	34	new	new	JJ
cord-281188-0cql96hu	298	35	way	way	NN
cord-281188-0cql96hu	298	36	to	to	TO
cord-281188-0cql96hu	298	37	assess	assess	VB
cord-281188-0cql96hu	298	38	quinolone	quinolone	NNP
cord-281188-0cql96hu	298	39	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	298	40	activity	activity	NN
cord-281188-0cql96hu	298	41	in	in	IN
cord-281188-0cql96hu	298	42	vitro	vitro	FW
cord-281188-0cql96hu	298	43	Superior	superior	JJ
cord-281188-0cql96hu	298	44	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	298	45	activity	activity	NN
cord-281188-0cql96hu	298	46	of	of	IN
cord-281188-0cql96hu	298	47	N	n	CD
cord-281188-0cql96hu	298	48	-	-	HYPH
cord-281188-0cql96hu	298	49	bromine	bromine	NN
cord-281188-0cql96hu	298	50	compounds	compound	NNS
cord-281188-0cql96hu	298	51	compared	compare	VBN
cord-281188-0cql96hu	298	52	to	to	IN
cord-281188-0cql96hu	298	53	their	-PRON-	PRP$
cord-281188-0cql96hu	298	54	N	n	CD
cord-281188-0cql96hu	298	55	-	-	HYPH
cord-281188-0cql96hu	298	56	chlorine	chlorine	NN
cord-281188-0cql96hu	298	57	analogues	analogue	NNS
cord-281188-0cql96hu	298	58	can	can	MD
cord-281188-0cql96hu	298	59	be	be	VB
cord-281188-0cql96hu	298	60	reversed	reverse	VBN
cord-281188-0cql96hu	298	61	under	under	IN
cord-281188-0cql96hu	298	62	protein	protein	NN
cord-281188-0cql96hu	298	63	load	load	NN
cord-281188-0cql96hu	298	64	Methods	method	NNS
cord-281188-0cql96hu	298	65	for	for	IN
cord-281188-0cql96hu	298	66	determining	determine	VBG
cord-281188-0cql96hu	298	67	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	298	68	activity	activity	NN
cord-281188-0cql96hu	298	69	of	of	IN
cord-281188-0cql96hu	298	70	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	298	71	agents	agent	NNS
cord-281188-0cql96hu	298	72	,	,	,
cord-281188-0cql96hu	298	73	approved	approve	VBN
cord-281188-0cql96hu	298	74	guideline	guideline	NN
cord-281188-0cql96hu	298	75	(	(	-LRB-
cord-281188-0cql96hu	298	76	CLSI	CLSI	NNP
cord-281188-0cql96hu	298	77	Antibiotic	antibiotic	JJ
cord-281188-0cql96hu	298	78	efficacy	efficacy	NN
cord-281188-0cql96hu	298	79	-	-	HYPH
cord-281188-0cql96hu	298	80	context	context	NN
cord-281188-0cql96hu	298	81	matters	matter	VBZ
cord-281188-0cql96hu	298	82	Molecular	molecular	JJ
cord-281188-0cql96hu	298	83	mechanisms	mechanism	NNS
cord-281188-0cql96hu	298	84	of	of	IN
cord-281188-0cql96hu	298	85	membrane	membrane	NN
cord-281188-0cql96hu	298	86	targeting	target	VBG
cord-281188-0cql96hu	298	87	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	298	88	Bacterial	bacterial	JJ
cord-281188-0cql96hu	298	89	cell	cell	NN
cord-281188-0cql96hu	298	90	disruption	disruption	NN
cord-281188-0cql96hu	298	91	:	:	:
cord-281188-0cql96hu	298	92	a	a	DT
cord-281188-0cql96hu	298	93	key	key	JJ
cord-281188-0cql96hu	298	94	unit	unit	NN
cord-281188-0cql96hu	298	95	operation	operation	NN
cord-281188-0cql96hu	298	96	in	in	IN
cord-281188-0cql96hu	298	97	the	the	DT
cord-281188-0cql96hu	298	98	recovery	recovery	NN
cord-281188-0cql96hu	298	99	of	of	IN
cord-281188-0cql96hu	298	100	intracellular	intracellular	JJ
cord-281188-0cql96hu	298	101	products	product	NNS
cord-281188-0cql96hu	298	102	Inhibition	inhibition	NN
cord-281188-0cql96hu	298	103	and	and	CC
cord-281188-0cql96hu	298	104	Destruction	destruction	NN
cord-281188-0cql96hu	298	105	of	of	IN
cord-281188-0cql96hu	298	106	the	the	DT
cord-281188-0cql96hu	298	107	Microbial	Microbial	NNP
cord-281188-0cql96hu	298	108	Cell	Cell	NNP
cord-281188-0cql96hu	298	109	Choline	Choline	NNP
cord-281188-0cql96hu	298	110	-	-	HYPH
cord-281188-0cql96hu	298	111	containing	contain	VBG
cord-281188-0cql96hu	298	112	teichoic	teichoic	NN
cord-281188-0cql96hu	298	113	acid	acid	NN
cord-281188-0cql96hu	298	114	as	as	IN
cord-281188-0cql96hu	298	115	a	a	DT
cord-281188-0cql96hu	298	116	structural	structural	JJ
cord-281188-0cql96hu	298	117	component	component	NN
cord-281188-0cql96hu	298	118	of	of	IN
cord-281188-0cql96hu	298	119	pneumococcal	pneumococcal	JJ
cord-281188-0cql96hu	298	120	cell	cell	NN
cord-281188-0cql96hu	298	121	www.nature.com/nrmicro	www.nature.com/nrmicro	NNP
cord-281188-0cql96hu	298	122	wall	wall	NN
cord-281188-0cql96hu	298	123	and	and	CC
cord-281188-0cql96hu	298	124	its	-PRON-	PRP$
cord-281188-0cql96hu	298	125	role	role	NN
cord-281188-0cql96hu	298	126	in	in	IN
cord-281188-0cql96hu	298	127	sensitivity	sensitivity	NN
cord-281188-0cql96hu	298	128	to	to	IN
cord-281188-0cql96hu	298	129	lysis	lysis	NN
cord-281188-0cql96hu	298	130	by	by	IN
cord-281188-0cql96hu	298	131	an	an	DT
cord-281188-0cql96hu	298	132	autolytic	autolytic	JJ
cord-281188-0cql96hu	298	133	enzyme	enzyme	NN
cord-281188-0cql96hu	299	1	The	the	DT
cord-281188-0cql96hu	299	2	molecular	molecular	JJ
cord-281188-0cql96hu	299	3	characterization	characterization	NN
cord-281188-0cql96hu	299	4	of	of	IN
cord-281188-0cql96hu	299	5	the	the	DT
cord-281188-0cql96hu	299	6	first	first	JJ
cord-281188-0cql96hu	299	7	autolytic	autolytic	JJ
cord-281188-0cql96hu	299	8	lysozyme	lysozyme	NNS
cord-281188-0cql96hu	299	9	of	of	IN
cord-281188-0cql96hu	299	10	Streptococcus	Streptococcus	NNP
cord-281188-0cql96hu	299	11	pneumoniae	pneumoniae	NN
cord-281188-0cql96hu	299	12	reveals	reveal	VBZ
cord-281188-0cql96hu	299	13	evolutionary	evolutionary	JJ
cord-281188-0cql96hu	299	14	mobile	mobile	JJ
cord-281188-0cql96hu	299	15	domains	domain	NNS
cord-281188-0cql96hu	299	16	Triggering	trigger	VBG
cord-281188-0cql96hu	299	17	of	of	IN
cord-281188-0cql96hu	299	18	autolytic	autolytic	JJ
cord-281188-0cql96hu	299	19	cell	cell	NN
cord-281188-0cql96hu	299	20	wall	wall	NN
cord-281188-0cql96hu	299	21	degradation	degradation	NN
cord-281188-0cql96hu	299	22	in	in	IN
cord-281188-0cql96hu	299	23	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	299	24	coli	coli	NNS
cord-281188-0cql96hu	299	25	by	by	IN
cord-281188-0cql96hu	299	26	beta	beta	NN
cord-281188-0cql96hu	299	27	-	-	HYPH
cord-281188-0cql96hu	299	28	lactam	lactam	NN
cord-281188-0cql96hu	299	29	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	299	30	Structural	structural	JJ
cord-281188-0cql96hu	299	31	basis	basis	NN
cord-281188-0cql96hu	299	32	of	of	IN
cord-281188-0cql96hu	299	33	peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	299	34	endopeptidase	endopeptidase	NN
cord-281188-0cql96hu	299	35	regulation	regulation	NN
cord-281188-0cql96hu	299	36	D	D	NNP
cord-281188-0cql96hu	299	37	-	-	HYPH
cord-281188-0cql96hu	299	38	Alanine	alanine	JJ
cord-281188-0cql96hu	299	39	deprivation	deprivation	NN
cord-281188-0cql96hu	299	40	of	of	IN
cord-281188-0cql96hu	299	41	Bacillus	bacillus	NN
cord-281188-0cql96hu	299	42	subtilis	subtili	NNS
cord-281188-0cql96hu	300	1	teichoic	teichoic	NNP
cord-281188-0cql96hu	300	2	acids	acids	NNPS
cord-281188-0cql96hu	300	3	is	be	VBZ
cord-281188-0cql96hu	300	4	without	without	IN
cord-281188-0cql96hu	300	5	effect	effect	NN
cord-281188-0cql96hu	300	6	on	on	IN
cord-281188-0cql96hu	300	7	cell	cell	NN
cord-281188-0cql96hu	300	8	growth	growth	NN
cord-281188-0cql96hu	300	9	and	and	CC
cord-281188-0cql96hu	300	10	morphology	morphology	NN
cord-281188-0cql96hu	300	11	but	but	CC
cord-281188-0cql96hu	300	12	affects	affect	VBZ
cord-281188-0cql96hu	300	13	the	the	DT
cord-281188-0cql96hu	300	14	autolytic	autolytic	JJ
cord-281188-0cql96hu	300	15	activity	activity	NN
cord-281188-0cql96hu	301	1	The	the	DT
cord-281188-0cql96hu	301	2	bacterial	bacterial	JJ
cord-281188-0cql96hu	301	3	cell	cell	NN
cord-281188-0cql96hu	301	4	envelope	envelope	NN
cord-281188-0cql96hu	302	1	A	a	DT
cord-281188-0cql96hu	302	2	switch	switch	NN
cord-281188-0cql96hu	302	3	in	in	IN
cord-281188-0cql96hu	302	4	surface	surface	NN
cord-281188-0cql96hu	302	5	polymer	polymer	NN
cord-281188-0cql96hu	302	6	biogenesis	biogenesis	NN
cord-281188-0cql96hu	302	7	triggers	trigger	VBZ
cord-281188-0cql96hu	302	8	growth	growth	NN
cord-281188-0cql96hu	302	9	-	-	HYPH
cord-281188-0cql96hu	302	10	phase	phase	NN
cord-281188-0cql96hu	302	11	-	-	HYPH
cord-281188-0cql96hu	302	12	dependent	dependent	JJ
cord-281188-0cql96hu	302	13	and	and	CC
cord-281188-0cql96hu	302	14	antibiotic	antibiotic	RB
cord-281188-0cql96hu	302	15	-	-	HYPH
cord-281188-0cql96hu	302	16	induced	induce	VBN
cord-281188-0cql96hu	302	17	bacteriolysis	bacteriolysis	NN
cord-281188-0cql96hu	303	1	When	when	WRB
cord-281188-0cql96hu	303	2	,	,	,
cord-281188-0cql96hu	303	3	how	how	WRB
cord-281188-0cql96hu	303	4	and	and	CC
cord-281188-0cql96hu	303	5	why	why	WRB
cord-281188-0cql96hu	303	6	?	?	.
cord-281188-0cql96hu	304	1	Regulated	regulate	VBN
cord-281188-0cql96hu	304	2	proteolysis	proteolysis	NN
cord-281188-0cql96hu	304	3	by	by	IN
cord-281188-0cql96hu	304	4	the	the	DT
cord-281188-0cql96hu	304	5	essential	essential	JJ
cord-281188-0cql96hu	304	6	FtsH	FtsH	NNP
cord-281188-0cql96hu	304	7	protease	protease	NN
cord-281188-0cql96hu	304	8	in	in	IN
cord-281188-0cql96hu	304	9	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	304	10	coli	coli	NNS
cord-281188-0cql96hu	304	11	Phosphatidylglycerol	Phosphatidylglycerol	NNP
cord-281188-0cql96hu	304	12	homeostasis	homeostasis	NN
cord-281188-0cql96hu	304	13	in	in	IN
cord-281188-0cql96hu	304	14	glycerol	glycerol	NN
cord-281188-0cql96hu	304	15	-	-	HYPH
cord-281188-0cql96hu	304	16	phosphate	phosphate	NN
cord-281188-0cql96hu	304	17	auxotrophs	auxotrophs	NN
cord-281188-0cql96hu	304	18	of	of	IN
cord-281188-0cql96hu	304	19	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	304	20	aureus	aureus	NNP
cord-281188-0cql96hu	305	1	The	the	DT
cord-281188-0cql96hu	305	2	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	305	3	coli	coli	NNS
cord-281188-0cql96hu	305	4	phospholipase	phospholipase	NN
cord-281188-0cql96hu	305	5	PldA	PldA	NNP
cord-281188-0cql96hu	305	6	regulates	regulate	VBZ
cord-281188-0cql96hu	305	7	outer	outer	JJ
cord-281188-0cql96hu	305	8	membrane	membrane	NN
cord-281188-0cql96hu	305	9	homeostasis	homeostasis	NN
cord-281188-0cql96hu	305	10	via	via	IN
cord-281188-0cql96hu	305	11	lipid	lipid	NN
cord-281188-0cql96hu	305	12	signaling	signal	VBG
cord-281188-0cql96hu	305	13	Distinct	distinct	JJ
cord-281188-0cql96hu	305	14	single	single	JJ
cord-281188-0cql96hu	305	15	-	-	HYPH
cord-281188-0cql96hu	305	16	cell	cell	NN
cord-281188-0cql96hu	305	17	morphological	morphological	JJ
cord-281188-0cql96hu	305	18	dynamics	dynamic	NNS
cord-281188-0cql96hu	305	19	under	under	IN
cord-281188-0cql96hu	305	20	beta	beta	NN
cord-281188-0cql96hu	305	21	-	-	HYPH
cord-281188-0cql96hu	305	22	lactam	lactam	NN
cord-281188-0cql96hu	305	23	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	305	24	Intricate	intricate	JJ
cord-281188-0cql96hu	305	25	crosstalk	crosstalk	NN
cord-281188-0cql96hu	305	26	between	between	IN
cord-281188-0cql96hu	305	27	lipopolysaccharide	lipopolysaccharide	NN
cord-281188-0cql96hu	305	28	,	,	,
cord-281188-0cql96hu	305	29	phospholipid	phospholipid	NN
cord-281188-0cql96hu	305	30	and	and	CC
cord-281188-0cql96hu	305	31	fatty	fatty	JJ
cord-281188-0cql96hu	305	32	acid	acid	NN
cord-281188-0cql96hu	305	33	metabolism	metabolism	NN
cord-281188-0cql96hu	305	34	in	in	IN
cord-281188-0cql96hu	305	35	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	305	36	coli	coli	NNS
cord-281188-0cql96hu	306	1	modulates	modulate	VBZ
cord-281188-0cql96hu	306	2	proteolysis	proteolysis	NN
cord-281188-0cql96hu	306	3	of	of	IN
cord-281188-0cql96hu	306	4	LpxC	LpxC	NNP
cord-281188-0cql96hu	306	5	Analysis	Analysis	NNP
cord-281188-0cql96hu	306	6	of	of	IN
cord-281188-0cql96hu	306	7	the	the	DT
cord-281188-0cql96hu	306	8	sodium	sodium	NN
cord-281188-0cql96hu	306	9	dodecyl	dodecyl	NNP
cord-281188-0cql96hu	306	10	sulfate	sulfate	NN
cord-281188-0cql96hu	306	11	-	-	HYPH
cord-281188-0cql96hu	306	12	stable	stable	JJ
cord-281188-0cql96hu	306	13	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	306	14	autolysins	autolysin	NNS
cord-281188-0cql96hu	306	15	of	of	IN
cord-281188-0cql96hu	306	16	select	select	JJ
cord-281188-0cql96hu	306	17	gram	gram	JJ
cord-281188-0cql96hu	306	18	-	-	HYPH
cord-281188-0cql96hu	306	19	negative	negative	JJ
cord-281188-0cql96hu	306	20	pathogens	pathogen	NNS
cord-281188-0cql96hu	306	21	by	by	IN
cord-281188-0cql96hu	306	22	using	use	VBG
cord-281188-0cql96hu	306	23	renaturing	renature	VBG
cord-281188-0cql96hu	306	24	polyacrylamide	polyacrylamide	NN
cord-281188-0cql96hu	306	25	gel	gel	NN
cord-281188-0cql96hu	306	26	electrophoresis	electrophoresis	NN
cord-281188-0cql96hu	306	27	Peptidoglycan	peptidoglycan	JJ
cord-281188-0cql96hu	306	28	hydrolases	hydrolase	NNS
cord-281188-0cql96hu	306	29	of	of	IN
cord-281188-0cql96hu	306	30	Bacterial	bacterial	JJ
cord-281188-0cql96hu	306	31	peptidoglycan	peptidoglycan	NN
cord-281188-0cql96hu	306	32	(	(	-LRB-
cord-281188-0cql96hu	306	33	murein	murein	NNP
cord-281188-0cql96hu	306	34	)	)	-RRB-
cord-281188-0cql96hu	306	35	hydrolases	hydrolase	NNS
cord-281188-0cql96hu	307	1	The	the	DT
cord-281188-0cql96hu	307	2	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	307	3	action	action	NN
cord-281188-0cql96hu	307	4	of	of	IN
cord-281188-0cql96hu	307	5	streptomycin	streptomycin	NN
cord-281188-0cql96hu	307	6	:	:	:
cord-281188-0cql96hu	307	7	membrane	membrane	NN
cord-281188-0cql96hu	307	8	permeabilization	permeabilization	NN
cord-281188-0cql96hu	307	9	caused	cause	VBN
cord-281188-0cql96hu	307	10	by	by	IN
cord-281188-0cql96hu	307	11	the	the	DT
cord-281188-0cql96hu	307	12	insertion	insertion	NN
cord-281188-0cql96hu	307	13	of	of	IN
cord-281188-0cql96hu	307	14	mistranslated	mistranslate	VBN
cord-281188-0cql96hu	307	15	proteins	protein	NNS
cord-281188-0cql96hu	307	16	into	into	IN
cord-281188-0cql96hu	307	17	the	the	DT
cord-281188-0cql96hu	307	18	cytoplasmic	cytoplasmic	JJ
cord-281188-0cql96hu	307	19	membrane	membrane	NN
cord-281188-0cql96hu	307	20	of	of	IN
cord-281188-0cql96hu	307	21	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	307	22	coli	coli	NNS
cord-281188-0cql96hu	307	23	and	and	CC
cord-281188-0cql96hu	307	24	subsequent	subsequent	JJ
cord-281188-0cql96hu	307	25	caging	caging	NN
cord-281188-0cql96hu	307	26	of	of	IN
cord-281188-0cql96hu	307	27	the	the	DT
cord-281188-0cql96hu	307	28	antibiotic	antibiotic	NN
cord-281188-0cql96hu	307	29	inside	inside	IN
cord-281188-0cql96hu	307	30	the	the	DT
cord-281188-0cql96hu	307	31	cells	cell	NNS
cord-281188-0cql96hu	307	32	due	due	JJ
cord-281188-0cql96hu	307	33	to	to	IN
cord-281188-0cql96hu	307	34	degradation	degradation	NN
cord-281188-0cql96hu	307	35	of	of	IN
cord-281188-0cql96hu	307	36	these	these	DT
cord-281188-0cql96hu	307	37	proteins	protein	NNS
cord-281188-0cql96hu	307	38	Mistranslation	mistranslation	NN
cord-281188-0cql96hu	307	39	of	of	IN
cord-281188-0cql96hu	307	40	membrane	membrane	NN
cord-281188-0cql96hu	307	41	proteins	protein	NNS
cord-281188-0cql96hu	307	42	and	and	CC
cord-281188-0cql96hu	307	43	two	two	CD
cord-281188-0cql96hu	307	44	-	-	HYPH
cord-281188-0cql96hu	307	45	component	component	NN
cord-281188-0cql96hu	307	46	system	system	NN
cord-281188-0cql96hu	307	47	activation	activation	NN
cord-281188-0cql96hu	307	48	trigger	trigger	NN
cord-281188-0cql96hu	307	49	antibiotic	antibiotic	NN
cord-281188-0cql96hu	307	50	-	-	HYPH
cord-281188-0cql96hu	307	51	mediated	mediate	VBN
cord-281188-0cql96hu	307	52	cell	cell	NN
cord-281188-0cql96hu	307	53	death	death	NN
cord-281188-0cql96hu	307	54	Quality	Quality	NNP
cord-281188-0cql96hu	307	55	control	control	NN
cord-281188-0cql96hu	307	56	of	of	IN
cord-281188-0cql96hu	307	57	cytoplasmic	cytoplasmic	JJ
cord-281188-0cql96hu	307	58	membrane	membrane	NN
cord-281188-0cql96hu	307	59	proteins	protein	NNS
cord-281188-0cql96hu	307	60	in	in	IN
cord-281188-0cql96hu	307	61	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	307	62	coli	coli	NNS
cord-281188-0cql96hu	307	63	ClpP	ClpP	NNP
cord-281188-0cql96hu	307	64	protease	protease	NN
cord-281188-0cql96hu	307	65	,	,	,
cord-281188-0cql96hu	307	66	a	a	DT
cord-281188-0cql96hu	307	67	promising	promising	JJ
cord-281188-0cql96hu	307	68	antimicrobial	antimicrobial	NN
cord-281188-0cql96hu	307	69	target	target	NN
cord-281188-0cql96hu	307	70	Dysregulation	Dysregulation	NNP
cord-281188-0cql96hu	307	71	of	of	IN
cord-281188-0cql96hu	307	72	bacterial	bacterial	JJ
cord-281188-0cql96hu	307	73	proteolytic	proteolytic	JJ
cord-281188-0cql96hu	307	74	machinery	machinery	NN
cord-281188-0cql96hu	307	75	by	by	IN
cord-281188-0cql96hu	307	76	a	a	DT
cord-281188-0cql96hu	307	77	new	new	JJ
cord-281188-0cql96hu	307	78	class	class	NN
cord-281188-0cql96hu	307	79	of	of	IN
cord-281188-0cql96hu	307	80	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	307	81	Not	not	RB
cord-281188-0cql96hu	307	82	quite	quite	RB
cord-281188-0cql96hu	307	83	dead	dead	JJ
cord-281188-0cql96hu	307	84	enough	enough	RB
cord-281188-0cql96hu	307	85	:	:	:
cord-281188-0cql96hu	307	86	on	on	IN
cord-281188-0cql96hu	307	87	bacterial	bacterial	JJ
cord-281188-0cql96hu	307	88	life	life	NN
cord-281188-0cql96hu	307	89	,	,	,
cord-281188-0cql96hu	307	90	culturability	culturability	NN
cord-281188-0cql96hu	307	91	,	,	,
cord-281188-0cql96hu	307	92	senescence	senescence	NN
cord-281188-0cql96hu	307	93	,	,	,
cord-281188-0cql96hu	307	94	and	and	CC
cord-281188-0cql96hu	307	95	death	death	NN
cord-281188-0cql96hu	307	96	Oxidative	oxidative	JJ
cord-281188-0cql96hu	307	97	stress	stress	NN
cord-281188-0cql96hu	307	98	,	,	,
cord-281188-0cql96hu	307	99	protein	protein	NN
cord-281188-0cql96hu	307	100	damage	damage	NN
cord-281188-0cql96hu	307	101	and	and	CC
cord-281188-0cql96hu	307	102	repair	repair	NN
cord-281188-0cql96hu	307	103	in	in	IN
cord-281188-0cql96hu	307	104	bacteria	bacteria	NNS
cord-281188-0cql96hu	307	105	Requirement	Requirement	NNP
cord-281188-0cql96hu	307	106	for	for	IN
cord-281188-0cql96hu	307	107	protein	protein	NN
cord-281188-0cql96hu	307	108	synthesis	synthesis	NN
cord-281188-0cql96hu	307	109	in	in	IN
cord-281188-0cql96hu	307	110	rec	rec	NN
cord-281188-0cql96hu	307	111	-	-	HYPH
cord-281188-0cql96hu	307	112	dependent	dependent	JJ
cord-281188-0cql96hu	307	113	repair	repair	NN
cord-281188-0cql96hu	307	114	of	of	IN
cord-281188-0cql96hu	307	115	deoxyribonucleic	deoxyribonucleic	NN
cord-281188-0cql96hu	307	116	acid	acid	NN
cord-281188-0cql96hu	307	117	in	in	IN
cord-281188-0cql96hu	307	118	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	307	119	coli	coli	NNS
cord-281188-0cql96hu	307	120	after	after	IN
cord-281188-0cql96hu	307	121	ultraviolet	ultraviolet	NN
cord-281188-0cql96hu	307	122	or	or	CC
cord-281188-0cql96hu	307	123	X	x	NN
cord-281188-0cql96hu	307	124	irradiation	irradiation	NN
cord-281188-0cql96hu	307	125	Quinolone	Quinolone	NNP
cord-281188-0cql96hu	307	126	-	-	HYPH
cord-281188-0cql96hu	307	127	mediated	mediate	VBN
cord-281188-0cql96hu	307	128	bacterial	bacterial	JJ
cord-281188-0cql96hu	307	129	death	death	NN
cord-281188-0cql96hu	307	130	Gyrase	Gyrase	NNP
cord-281188-0cql96hu	307	131	inhibitors	inhibitor	NNS
cord-281188-0cql96hu	307	132	induce	induce	VBP
cord-281188-0cql96hu	307	133	an	an	DT
cord-281188-0cql96hu	307	134	oxidative	oxidative	JJ
cord-281188-0cql96hu	307	135	damage	damage	NN
cord-281188-0cql96hu	307	136	cellular	cellular	JJ
cord-281188-0cql96hu	307	137	death	death	NN
cord-281188-0cql96hu	307	138	pathway	pathway	NN
cord-281188-0cql96hu	307	139	in	in	IN
cord-281188-0cql96hu	307	140	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	307	141	coli	coli	VBZ
cord-281188-0cql96hu	307	142	Crystal	Crystal	NNP
cord-281188-0cql96hu	307	143	structure	structure	NN
cord-281188-0cql96hu	307	144	of	of	IN
cord-281188-0cql96hu	307	145	RecBCD	RecBCD	NNP
cord-281188-0cql96hu	307	146	enzyme	enzyme	NN
cord-281188-0cql96hu	307	147	reveals	reveal	VBZ
cord-281188-0cql96hu	307	148	a	a	DT
cord-281188-0cql96hu	307	149	machine	machine	NN
cord-281188-0cql96hu	307	150	for	for	IN
cord-281188-0cql96hu	307	151	processing	process	VBG
cord-281188-0cql96hu	307	152	DNA	dna	NN
cord-281188-0cql96hu	307	153	breaks	break	NNS
cord-281188-0cql96hu	308	1	Oxidation	oxidation	NN
cord-281188-0cql96hu	308	2	of	of	IN
cord-281188-0cql96hu	308	3	the	the	DT
cord-281188-0cql96hu	308	4	guanine	guanine	NN
cord-281188-0cql96hu	308	5	nucleotide	nucleotide	JJ
cord-281188-0cql96hu	308	6	pool	pool	NN
cord-281188-0cql96hu	308	7	underlies	underlie	VBZ
cord-281188-0cql96hu	308	8	cell	cell	NN
cord-281188-0cql96hu	308	9	death	death	NN
cord-281188-0cql96hu	308	10	by	by	IN
cord-281188-0cql96hu	308	11	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	308	12	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	308	13	Exploring	explore	VBG
cord-281188-0cql96hu	308	14	synergy	synergy	NN
cord-281188-0cql96hu	308	15	between	between	IN
cord-281188-0cql96hu	308	16	classic	classic	JJ
cord-281188-0cql96hu	308	17	mutagens	mutagen	NNS
cord-281188-0cql96hu	308	18	and	and	CC
cord-281188-0cql96hu	308	19	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	308	20	to	to	TO
cord-281188-0cql96hu	308	21	examine	examine	VB
cord-281188-0cql96hu	308	22	mechanisms	mechanism	NNS
cord-281188-0cql96hu	308	23	of	of	IN
cord-281188-0cql96hu	308	24	synergy	synergy	NN
cord-281188-0cql96hu	308	25	and	and	CC
cord-281188-0cql96hu	308	26	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	308	27	action	action	NN
cord-281188-0cql96hu	308	28	Antagonism	antagonism	NN
cord-281188-0cql96hu	308	29	between	between	IN
cord-281188-0cql96hu	308	30	bacteriostatic	bacteriostatic	JJ
cord-281188-0cql96hu	308	31	and	and	CC
cord-281188-0cql96hu	308	32	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	308	33	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	309	1	is	be	VBZ
cord-281188-0cql96hu	309	2	prevalent	prevalent	JJ
cord-281188-0cql96hu	309	3	Chromosomal	chromosomal	JJ
cord-281188-0cql96hu	309	4	fragmentation	fragmentation	NN
cord-281188-0cql96hu	309	5	in	in	IN
cord-281188-0cql96hu	309	6	dUTPase	dutpase	JJ
cord-281188-0cql96hu	309	7	-	-	HYPH
cord-281188-0cql96hu	309	8	deficient	deficient	JJ
cord-281188-0cql96hu	309	9	mutants	mutant	NNS
cord-281188-0cql96hu	309	10	of	of	IN
cord-281188-0cql96hu	309	11	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	309	12	coli	coli	NNS
cord-281188-0cql96hu	309	13	and	and	CC
cord-281188-0cql96hu	309	14	its	-PRON-	PRP$
cord-281188-0cql96hu	309	15	recombinational	recombinational	JJ
cord-281188-0cql96hu	309	16	repair	repair	NN
cord-281188-0cql96hu	309	17	Nutritional	nutritional	JJ
cord-281188-0cql96hu	309	18	conditions	condition	NNS
cord-281188-0cql96hu	309	19	and	and	CC
cord-281188-0cql96hu	309	20	oxygen	oxygen	NN
cord-281188-0cql96hu	309	21	concentration	concentration	NN
cord-281188-0cql96hu	310	1	affect	affect	VB
cord-281188-0cql96hu	310	2	spontaneous	spontaneous	JJ
cord-281188-0cql96hu	310	3	occurrence	occurrence	NN
cord-281188-0cql96hu	310	4	of	of	IN
cord-281188-0cql96hu	310	5	homologous	homologous	JJ
cord-281188-0cql96hu	310	6	recombination	recombination	NN
cord-281188-0cql96hu	310	7	events	event	NNS
cord-281188-0cql96hu	310	8	but	but	CC
cord-281188-0cql96hu	310	9	not	not	RB
cord-281188-0cql96hu	310	10	spontaneous	spontaneous	JJ
cord-281188-0cql96hu	310	11	mutagenesis	mutagenesis	NN
cord-281188-0cql96hu	310	12	in	in	IN
cord-281188-0cql96hu	310	13	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	310	14	coli	coli	NNS
cord-281188-0cql96hu	310	15	Bacterial	bacterial	JJ
cord-281188-0cql96hu	310	16	programmed	program	VBD
cord-281188-0cql96hu	310	17	cell	cell	NN
cord-281188-0cql96hu	310	18	death	death	NN
cord-281188-0cql96hu	310	19	:	:	:
cord-281188-0cql96hu	310	20	making	make	VBG
cord-281188-0cql96hu	310	21	sense	sense	NN
cord-281188-0cql96hu	310	22	of	of	IN
cord-281188-0cql96hu	310	23	a	a	DT
cord-281188-0cql96hu	310	24	paradox	paradox	NN
cord-281188-0cql96hu	310	25	Quantifying	quantify	VBG
cord-281188-0cql96hu	310	26	absolute	absolute	JJ
cord-281188-0cql96hu	310	27	protein	protein	NN
cord-281188-0cql96hu	310	28	synthesis	synthesis	NN
cord-281188-0cql96hu	310	29	rates	rate	NNS
cord-281188-0cql96hu	310	30	reveals	reveal	VBZ
cord-281188-0cql96hu	310	31	principles	principle	NNS
cord-281188-0cql96hu	310	32	underlying	underlie	VBG
cord-281188-0cql96hu	310	33	allocation	allocation	NN
cord-281188-0cql96hu	310	34	of	of	IN
cord-281188-0cql96hu	310	35	cellular	cellular	JJ
cord-281188-0cql96hu	310	36	resources	resource	NNS
cord-281188-0cql96hu	310	37	Markerless	Markerless	NNP
cord-281188-0cql96hu	310	38	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	310	39	coli	coli	NNS
cord-281188-0cql96hu	310	40	rrn	rrn	VBP
cord-281188-0cql96hu	310	41	deletion	deletion	NN
cord-281188-0cql96hu	310	42	strains	strain	NNS
cord-281188-0cql96hu	310	43	for	for	IN
cord-281188-0cql96hu	310	44	genetic	genetic	JJ
cord-281188-0cql96hu	310	45	determination	determination	NN
cord-281188-0cql96hu	310	46	of	of	IN
cord-281188-0cql96hu	310	47	ribosomal	ribosomal	JJ
cord-281188-0cql96hu	310	48	binding	binding	NN
cord-281188-0cql96hu	310	49	sites	site	NNS
cord-281188-0cql96hu	311	1	A.	a.	NN
cord-281188-0cql96hu	311	2	damage	damage	NN
cord-281188-0cql96hu	311	3	by	by	IN
cord-281188-0cql96hu	311	4	hydrogen	hydrogen	NN
cord-281188-0cql96hu	311	5	peroxide	peroxide	NN
cord-281188-0cql96hu	311	6	through	through	IN
cord-281188-0cql96hu	311	7	the	the	DT
cord-281188-0cql96hu	311	8	Fenton	Fenton	NNP
cord-281188-0cql96hu	311	9	reaction	reaction	NN
cord-281188-0cql96hu	311	10	in	in	IN
cord-281188-0cql96hu	311	11	vivo	vivo	NN
cord-281188-0cql96hu	311	12	and	and	CC
cord-281188-0cql96hu	311	13	in	in	IN
cord-281188-0cql96hu	311	14	vitro	vitro	FW
cord-281188-0cql96hu	311	15	Fe	Fe	NNP
cord-281188-0cql96hu	311	16	-	-	HYPH
cord-281188-0cql96hu	311	17	S	S	NNP
cord-281188-0cql96hu	311	18	cluster	cluster	NN
cord-281188-0cql96hu	311	19	biosynthesis	biosynthesis	NN
cord-281188-0cql96hu	311	20	controls	control	NNS
cord-281188-0cql96hu	311	21	uptake	uptake	NN
cord-281188-0cql96hu	311	22	of	of	IN
cord-281188-0cql96hu	311	23	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	311	24	in	in	IN
cord-281188-0cql96hu	311	25	a	a	DT
cord-281188-0cql96hu	311	26	ROS	ROS	NNP
cord-281188-0cql96hu	311	27	-	-	HYPH
cord-281188-0cql96hu	311	28	less	less	JJR
cord-281188-0cql96hu	311	29	death	death	NN
cord-281188-0cql96hu	311	30	pathway	pathway	NN
cord-281188-0cql96hu	311	31	Cell	cell	NN
cord-281188-0cql96hu	311	32	death	death	NN
cord-281188-0cql96hu	311	33	from	from	IN
cord-281188-0cql96hu	311	34	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	311	35	without	without	IN
cord-281188-0cql96hu	311	36	the	the	DT
cord-281188-0cql96hu	311	37	involvement	involvement	NN
cord-281188-0cql96hu	311	38	of	of	IN
cord-281188-0cql96hu	311	39	reactive	reactive	JJ
cord-281188-0cql96hu	311	40	oxygen	oxygen	NN
cord-281188-0cql96hu	311	41	species	specie	NNS
cord-281188-0cql96hu	311	42	Killing	kill	VBG
cord-281188-0cql96hu	311	43	by	by	IN
cord-281188-0cql96hu	311	44	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	311	45	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	311	46	does	do	VBZ
cord-281188-0cql96hu	311	47	not	not	RB
cord-281188-0cql96hu	311	48	depend	depend	VB
cord-281188-0cql96hu	311	49	on	on	IN
cord-281188-0cql96hu	311	50	reactive	reactive	JJ
cord-281188-0cql96hu	311	51	oxygen	oxygen	NN
cord-281188-0cql96hu	311	52	species	specie	NNS
cord-281188-0cql96hu	312	1	Antibiotics	antibiotic	NNS
cord-281188-0cql96hu	312	2	induce	induce	VBP
cord-281188-0cql96hu	312	3	redox	redox	NN
cord-281188-0cql96hu	312	4	-	-	HYPH
cord-281188-0cql96hu	312	5	related	relate	VBN
cord-281188-0cql96hu	312	6	physiological	physiological	JJ
cord-281188-0cql96hu	312	7	alterations	alteration	NNS
cord-281188-0cql96hu	312	8	as	as	IN
cord-281188-0cql96hu	312	9	part	part	NN
cord-281188-0cql96hu	312	10	of	of	IN
cord-281188-0cql96hu	312	11	their	-PRON-	PRP$
cord-281188-0cql96hu	312	12	lethality	lethality	NN
cord-281188-0cql96hu	312	13	Unraveling	unravel	VBG
cord-281188-0cql96hu	312	14	the	the	DT
cord-281188-0cql96hu	312	15	physiological	physiological	JJ
cord-281188-0cql96hu	312	16	complexities	complexity	NNS
cord-281188-0cql96hu	312	17	of	of	IN
cord-281188-0cql96hu	312	18	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	312	19	lethality	lethality	NN
cord-281188-0cql96hu	312	20	Mechanism	mechanism	NN
cord-281188-0cql96hu	312	21	of	of	IN
cord-281188-0cql96hu	312	22	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	312	23	action	action	NN
cord-281188-0cql96hu	312	24	of	of	IN
cord-281188-0cql96hu	312	25	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	312	26	Kinetics	Kinetics	NNP
cord-281188-0cql96hu	312	27	of	of	IN
cord-281188-0cql96hu	312	28	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	312	29	activity	activity	NN
cord-281188-0cql96hu	312	30	of	of	IN
cord-281188-0cql96hu	312	31	aminoglycosides	aminoglycoside	NNS
cord-281188-0cql96hu	312	32	during	during	IN
cord-281188-0cql96hu	312	33	dynamic	dynamic	JJ
cord-281188-0cql96hu	312	34	dilution	dilution	NN
cord-281188-0cql96hu	312	35	Mistranslation	mistranslation	NN
cord-281188-0cql96hu	312	36	and	and	CC
cord-281188-0cql96hu	312	37	genetic	genetic	JJ
cord-281188-0cql96hu	312	38	variability	variability	NN
cord-281188-0cql96hu	312	39	:	:	:
cord-281188-0cql96hu	312	40	the	the	DT
cord-281188-0cql96hu	312	41	effect	effect	NN
cord-281188-0cql96hu	312	42	of	of	IN
cord-281188-0cql96hu	312	43	streptomycin	streptomycin	NN
cord-281188-0cql96hu	312	44	Roles	role	NNS
cord-281188-0cql96hu	312	45	of	of	IN
cord-281188-0cql96hu	312	46	specific	specific	JJ
cord-281188-0cql96hu	312	47	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	312	48	-	-	HYPH
cord-281188-0cql96hu	312	49	ribosome	ribosome	NN
cord-281188-0cql96hu	312	50	interactions	interaction	NNS
cord-281188-0cql96hu	312	51	in	in	IN
cord-281188-0cql96hu	312	52	the	the	DT
cord-281188-0cql96hu	312	53	inhibition	inhibition	NN
cord-281188-0cql96hu	312	54	of	of	IN
cord-281188-0cql96hu	312	55	translation	translation	NN
cord-281188-0cql96hu	312	56	armA	armA	.
cord-281188-0cql96hu	312	57	and	and	CC
cord-281188-0cql96hu	312	58	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	312	59	resistance	resistance	NN
cord-281188-0cql96hu	312	60	in	in	IN
cord-281188-0cql96hu	312	61	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	312	62	coli	coli	VBZ
cord-281188-0cql96hu	312	63	Comparative	comparative	JJ
cord-281188-0cql96hu	312	64	activity	activity	NN
cord-281188-0cql96hu	312	65	of	of	IN
cord-281188-0cql96hu	312	66	ceftriaxone	ceftriaxone	NN
cord-281188-0cql96hu	312	67	,	,	,
cord-281188-0cql96hu	312	68	ciprofloxacin	ciprofloxacin	NN
cord-281188-0cql96hu	312	69	,	,	,
cord-281188-0cql96hu	312	70	and	and	CC
cord-281188-0cql96hu	312	71	gentamicin	gentamicin	NN
cord-281188-0cql96hu	312	72	as	as	IN
cord-281188-0cql96hu	312	73	a	a	DT
cord-281188-0cql96hu	312	74	function	function	NN
cord-281188-0cql96hu	312	75	of	of	IN
cord-281188-0cql96hu	312	76	bacterial	bacterial	JJ
cord-281188-0cql96hu	312	77	growth	growth	NN
cord-281188-0cql96hu	312	78	rate	rate	NN
cord-281188-0cql96hu	312	79	probed	probe	VBN
cord-281188-0cql96hu	312	80	by	by	IN
cord-281188-0cql96hu	312	81	escherichia	escherichia	NNP
cord-281188-0cql96hu	312	82	coli	coli	NNP
cord-281188-0cql96hu	312	83	chromosome	chromosome	NN
cord-281188-0cql96hu	312	84	replication	replication	NN
cord-281188-0cql96hu	312	85	in	in	IN
cord-281188-0cql96hu	312	86	the	the	DT
cord-281188-0cql96hu	312	87	mouse	mouse	NN
cord-281188-0cql96hu	312	88	peritonitis	peritonitis	NN
cord-281188-0cql96hu	312	89	model	model	NN
cord-281188-0cql96hu	312	90	Bacterial	bacterial	JJ
cord-281188-0cql96hu	312	91	uptake	uptake	NN
cord-281188-0cql96hu	312	92	of	of	IN
cord-281188-0cql96hu	312	93	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	312	94	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	312	95	Aminoglycoside	Aminoglycoside	NNP
cord-281188-0cql96hu	312	96	modifying	modify	VBG
cord-281188-0cql96hu	312	97	enzymes	enzyme	NNS
cord-281188-0cql96hu	312	98	Binding	Binding	NNP
cord-281188-0cql96hu	312	99	of	of	IN
cord-281188-0cql96hu	312	100	polycationic	polycationic	NNP
cord-281188-0cql96hu	312	101	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	312	102	and	and	CC
cord-281188-0cql96hu	312	103	polyamines	polyamine	NNS
cord-281188-0cql96hu	312	104	to	to	IN
cord-281188-0cql96hu	312	105	lipopolysaccharides	lipopolysaccharides	NNP
cord-281188-0cql96hu	312	106	of	of	IN
cord-281188-0cql96hu	312	107	Pseudomonas	Pseudomonas	NNP
cord-281188-0cql96hu	312	108	aeruginosa	aeruginosa	NN
cord-281188-0cql96hu	312	109	Surface	Surface	NNP
cord-281188-0cql96hu	312	110	action	action	NN
cord-281188-0cql96hu	312	111	of	of	IN
cord-281188-0cql96hu	312	112	gentamicin	gentamicin	NN
cord-281188-0cql96hu	312	113	on	on	IN
cord-281188-0cql96hu	312	114	Pseudomonas	Pseudomonas	NNP
cord-281188-0cql96hu	312	115	aeruginosa	aeruginosa	NN
cord-281188-0cql96hu	313	1	The	the	DT
cord-281188-0cql96hu	313	2	sequence	sequence	NN
cord-281188-0cql96hu	313	3	of	of	IN
cord-281188-0cql96hu	313	4	some	some	DT
cord-281188-0cql96hu	313	5	effects	effect	NNS
cord-281188-0cql96hu	313	6	of	of	IN
cord-281188-0cql96hu	313	7	streptomycin	streptomycin	NNS
cord-281188-0cql96hu	313	8	in	in	IN
cord-281188-0cql96hu	313	9	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	313	10	Coli	Coli	NNP
cord-281188-0cql96hu	313	11	Alarmone	Alarmone	NNP
cord-281188-0cql96hu	313	12	Ap4A	Ap4A	NNS
cord-281188-0cql96hu	313	13	is	be	VBZ
cord-281188-0cql96hu	313	14	elevated	elevate	VBN
cord-281188-0cql96hu	313	15	by	by	IN
cord-281188-0cql96hu	313	16	aminoglycoside	aminoglycoside	JJ
cord-281188-0cql96hu	313	17	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	313	18	and	and	CC
cord-281188-0cql96hu	313	19	enhances	enhance	VBZ
cord-281188-0cql96hu	313	20	their	-PRON-	PRP$
cord-281188-0cql96hu	313	21	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	313	22	activity	activity	NN
cord-281188-0cql96hu	313	23	Roles	role	NNS
cord-281188-0cql96hu	313	24	of	of	IN
cord-281188-0cql96hu	313	25	ribosomal	ribosomal	JJ
cord-281188-0cql96hu	313	26	binding	binding	NN
cord-281188-0cql96hu	313	27	,	,	,
cord-281188-0cql96hu	313	28	membrane	membrane	NN
cord-281188-0cql96hu	313	29	potential	potential	NN
cord-281188-0cql96hu	313	30	,	,	,
cord-281188-0cql96hu	313	31	and	and	CC
cord-281188-0cql96hu	313	32	electron	electron	NN
cord-281188-0cql96hu	313	33	transport	transport	NN
cord-281188-0cql96hu	313	34	in	in	IN
cord-281188-0cql96hu	313	35	bacterial	bacterial	JJ
cord-281188-0cql96hu	313	36	uptake	uptake	NN
cord-281188-0cql96hu	313	37	of	of	IN
cord-281188-0cql96hu	313	38	streptomycin	streptomycin	NNS
cord-281188-0cql96hu	313	39	and	and	CC
cord-281188-0cql96hu	313	40	gentamicin	gentamicin	NN
cord-281188-0cql96hu	313	41	Mechanisms	Mechanisms	NNPS
cord-281188-0cql96hu	313	42	of	of	IN
cord-281188-0cql96hu	313	43	action	action	NN
cord-281188-0cql96hu	313	44	of	of	IN
cord-281188-0cql96hu	313	45	antimicrobials	antimicrobial	NNS
cord-281188-0cql96hu	313	46	:	:	:
cord-281188-0cql96hu	313	47	focus	focus	VB
cord-281188-0cql96hu	313	48	on	on	IN
cord-281188-0cql96hu	313	49	fluoroquinolones	fluoroquinolone	NNS
cord-281188-0cql96hu	313	50	Fluoroquinolone	Fluoroquinolone	NNP
cord-281188-0cql96hu	313	51	-	-	HYPH
cord-281188-0cql96hu	313	52	gyrase	gyrase	NNP
cord-281188-0cql96hu	313	53	-	-	HYPH
cord-281188-0cql96hu	313	54	DNA	dna	NN
cord-281188-0cql96hu	313	55	complexes	complex	NNS
cord-281188-0cql96hu	313	56	:	:	:
cord-281188-0cql96hu	313	57	two	two	CD
cord-281188-0cql96hu	313	58	modes	mode	NNS
cord-281188-0cql96hu	313	59	of	of	IN
cord-281188-0cql96hu	313	60	drug	drug	NN
cord-281188-0cql96hu	313	61	binding	bind	VBG
cord-281188-0cql96hu	313	62	Relationship	relationship	NN
cord-281188-0cql96hu	313	63	between	between	IN
cord-281188-0cql96hu	313	64	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	313	65	coli	coli	VBZ
cord-281188-0cql96hu	313	66	growth	growth	NN
cord-281188-0cql96hu	313	67	rate	rate	NN
cord-281188-0cql96hu	313	68	and	and	CC
cord-281188-0cql96hu	313	69	bacterial	bacterial	JJ
cord-281188-0cql96hu	313	70	susceptibility	susceptibility	NN
cord-281188-0cql96hu	313	71	to	to	IN
cord-281188-0cql96hu	313	72	ciprofloxacin	ciprofloxacin	NN
cord-281188-0cql96hu	313	73	Effects	effect	NNS
cord-281188-0cql96hu	313	74	of	of	IN
cord-281188-0cql96hu	313	75	rifampicin	rifampicin	NNS
cord-281188-0cql96hu	313	76	on	on	IN
cord-281188-0cql96hu	313	77	synthesis	synthesis	NN
cord-281188-0cql96hu	313	78	and	and	CC
cord-281188-0cql96hu	313	79	functional	functional	JJ
cord-281188-0cql96hu	313	80	activity	activity	NN
cord-281188-0cql96hu	313	81	of	of	IN
cord-281188-0cql96hu	313	82	DNA	dna	NN
cord-281188-0cql96hu	313	83	-	-	HYPH
cord-281188-0cql96hu	313	84	dependent	dependent	JJ
cord-281188-0cql96hu	313	85	RNA	RNA	NNP
cord-281188-0cql96hu	313	86	polymerase	polymerase	NN
cord-281188-0cql96hu	313	87	in	in	IN
cord-281188-0cql96hu	313	88	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	313	89	coli	coli	VBZ
cord-281188-0cql96hu	313	90	Concentration	concentration	NN
cord-281188-0cql96hu	313	91	-	-	HYPH
cord-281188-0cql96hu	313	92	dependent	dependent	JJ
cord-281188-0cql96hu	313	93	Mycobacterium	Mycobacterium	NNP
cord-281188-0cql96hu	313	94	tuberculosis	tuberculosis	NN
cord-281188-0cql96hu	313	95	killing	killing	NN
cord-281188-0cql96hu	313	96	and	and	CC
cord-281188-0cql96hu	313	97	prevention	prevention	NN
cord-281188-0cql96hu	313	98	of	of	IN
cord-281188-0cql96hu	313	99	resistance	resistance	NN
cord-281188-0cql96hu	313	100	by	by	IN
cord-281188-0cql96hu	313	101	rifampin	rifampin	NNP
cord-281188-0cql96hu	314	1	Could	Could	MD
cord-281188-0cql96hu	314	2	high	high	JJ
cord-281188-0cql96hu	314	3	-	-	HYPH
cord-281188-0cql96hu	314	4	concentration	concentration	NN
cord-281188-0cql96hu	314	5	rifampicin	rifampicin	NNS
cord-281188-0cql96hu	314	6	kill	kill	VBP
cord-281188-0cql96hu	314	7	rifampicin	rifampicin	NN
cord-281188-0cql96hu	314	8	-	-	HYPH
cord-281188-0cql96hu	314	9	resistant	resistant	JJ
cord-281188-0cql96hu	314	10	M.	M.	NNP
cord-281188-0cql96hu	314	11	tuberculosis	tuberculosis	NN
cord-281188-0cql96hu	314	12	?	?	.
cord-281188-0cql96hu	315	1	Rifampicin	Rifampicin	NNP
cord-281188-0cql96hu	315	2	MIC	MIC	NNP
cord-281188-0cql96hu	315	3	test	test	NN
cord-281188-0cql96hu	315	4	in	in	IN
cord-281188-0cql96hu	315	5	rifampicin	rifampicin	NN
cord-281188-0cql96hu	315	6	-	-	HYPH
cord-281188-0cql96hu	315	7	resistant	resistant	JJ
cord-281188-0cql96hu	315	8	isolates	isolate	NNS
cord-281188-0cql96hu	315	9	from	from	IN
cord-281188-0cql96hu	315	10	patients	patient	NNS
cord-281188-0cql96hu	315	11	with	with	IN
cord-281188-0cql96hu	315	12	osteoarticular	osteoarticular	NNP
cord-281188-0cql96hu	315	13	tuberculosis	tuberculosis	NN
cord-281188-0cql96hu	316	1	A	a	DT
cord-281188-0cql96hu	316	2	NusE	NusE	NNP
cord-281188-0cql96hu	316	3	:	:	:
cord-281188-0cql96hu	317	1	NusG	NusG	NNP
cord-281188-0cql96hu	317	2	complex	complex	JJ
cord-281188-0cql96hu	317	3	links	link	NNS
cord-281188-0cql96hu	317	4	transcription	transcription	NN
cord-281188-0cql96hu	317	5	and	and	CC
cord-281188-0cql96hu	317	6	translation	translation	NN
cord-281188-0cql96hu	317	7	Cooperation	Cooperation	NNP
cord-281188-0cql96hu	317	8	between	between	IN
cord-281188-0cql96hu	317	9	translating	translate	VBG
cord-281188-0cql96hu	317	10	ribosomes	ribosome	NNS
cord-281188-0cql96hu	317	11	and	and	CC
cord-281188-0cql96hu	317	12	RNA	RNA	NNP
cord-281188-0cql96hu	317	13	polymerase	polymerase	NN
cord-281188-0cql96hu	317	14	in	in	IN
cord-281188-0cql96hu	317	15	transcription	transcription	NN
cord-281188-0cql96hu	317	16	elongation	elongation	NN
cord-281188-0cql96hu	317	17	MazFmediated	mazfmediate	VBN
cord-281188-0cql96hu	317	18	cell	cell	NN
cord-281188-0cql96hu	317	19	death	death	NN
cord-281188-0cql96hu	317	20	in	in	IN
cord-281188-0cql96hu	317	21	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	317	22	coli	coli	NNS
cord-281188-0cql96hu	317	23	:	:	:
cord-281188-0cql96hu	317	24	a	a	DT
cord-281188-0cql96hu	317	25	point	point	NN
cord-281188-0cql96hu	317	26	of	of	IN
cord-281188-0cql96hu	317	27	no	no	DT
cord-281188-0cql96hu	317	28	return	return	NN
cord-281188-0cql96hu	317	29	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	317	30	coli	coli	NNS
cord-281188-0cql96hu	318	1	MazF	MazF	NNP
cord-281188-0cql96hu	318	2	leads	lead	VBZ
cord-281188-0cql96hu	318	3	to	to	IN
cord-281188-0cql96hu	318	4	the	the	DT
cord-281188-0cql96hu	318	5	simultaneous	simultaneous	JJ
cord-281188-0cql96hu	318	6	selective	selective	JJ
cord-281188-0cql96hu	318	7	synthesis	synthesis	NN
cord-281188-0cql96hu	318	8	of	of	IN
cord-281188-0cql96hu	318	9	both	both	DT
cord-281188-0cql96hu	318	10	"	"	``
cord-281188-0cql96hu	318	11	death	death	NN
cord-281188-0cql96hu	318	12	proteins	protein	NNS
cord-281188-0cql96hu	318	13	"	"	''
cord-281188-0cql96hu	318	14	and	and	CC
cord-281188-0cql96hu	318	15	"	"	``
cord-281188-0cql96hu	318	16	survival	survival	NN
cord-281188-0cql96hu	318	17	proteins	protein	NNS
cord-281188-0cql96hu	319	1	Rifamycin	Rifamycin	NNP
cord-281188-0cql96hu	319	2	action	action	NN
cord-281188-0cql96hu	319	3	on	on	IN
cord-281188-0cql96hu	319	4	RNA	RNA	NNP
cord-281188-0cql96hu	319	5	polymerase	polymerase	NN
cord-281188-0cql96hu	319	6	in	in	IN
cord-281188-0cql96hu	319	7	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	319	8	-	-	HYPH
cord-281188-0cql96hu	319	9	tolerant	tolerant	JJ
cord-281188-0cql96hu	319	10	Mycobacterium	Mycobacterium	NNP
cord-281188-0cql96hu	319	11	tuberculosis	tuberculosis	NN
cord-281188-0cql96hu	319	12	results	result	VBZ
cord-281188-0cql96hu	319	13	in	in	IN
cord-281188-0cql96hu	319	14	differentially	differentially	RB
cord-281188-0cql96hu	319	15	detectable	detectable	JJ
cord-281188-0cql96hu	319	16	populations	population	NNS
cord-281188-0cql96hu	320	1	Selective	selective	JJ
cord-281188-0cql96hu	320	2	protein	protein	NN
cord-281188-0cql96hu	320	3	synthesis	synthesis	NN
cord-281188-0cql96hu	320	4	by	by	IN
cord-281188-0cql96hu	320	5	ribosomes	ribosome	NNS
cord-281188-0cql96hu	320	6	with	with	IN
cord-281188-0cql96hu	320	7	a	a	DT
cord-281188-0cql96hu	320	8	drugobstructed	drugobstructe	VBN
cord-281188-0cql96hu	320	9	exit	exit	NN
cord-281188-0cql96hu	320	10	tunnel	tunnel	NN
cord-281188-0cql96hu	320	11	Inhibition	Inhibition	NNP
cord-281188-0cql96hu	320	12	of	of	IN
cord-281188-0cql96hu	320	13	RNA	RNA	NNP
cord-281188-0cql96hu	320	14	polymerase	polymerase	NN
cord-281188-0cql96hu	320	15	by	by	IN
cord-281188-0cql96hu	320	16	rifampicin	rifampicin	NNS
cord-281188-0cql96hu	320	17	and	and	CC
cord-281188-0cql96hu	320	18	rifamycin	rifamycin	NN
cord-281188-0cql96hu	320	19	-	-	HYPH
cord-281188-0cql96hu	320	20	like	like	JJ
cord-281188-0cql96hu	320	21	molecules	molecule	NNS
cord-281188-0cql96hu	320	22	Mechanism	Mechanism	NNP
cord-281188-0cql96hu	320	23	of	of	IN
cord-281188-0cql96hu	320	24	action	action	NN
cord-281188-0cql96hu	320	25	of	of	IN
cord-281188-0cql96hu	320	26	penicillins	penicillin	NNS
cord-281188-0cql96hu	320	27	:	:	:
cord-281188-0cql96hu	321	1	a	a	DT
cord-281188-0cql96hu	321	2	proposal	proposal	NN
cord-281188-0cql96hu	321	3	based	base	VBN
cord-281188-0cql96hu	321	4	on	on	IN
cord-281188-0cql96hu	321	5	their	-PRON-	PRP$
cord-281188-0cql96hu	321	6	structural	structural	JJ
cord-281188-0cql96hu	321	7	similarity	similarity	NN
cord-281188-0cql96hu	321	8	to	to	IN
cord-281188-0cql96hu	321	9	acyl	acyl	NN
cord-281188-0cql96hu	321	10	-	-	HYPH
cord-281188-0cql96hu	321	11	D	d	NN
cord-281188-0cql96hu	321	12	-	-	HYPH
cord-281188-0cql96hu	321	13	alanyl	alanyl	NN
cord-281188-0cql96hu	321	14	-	-	HYPH
cord-281188-0cql96hu	321	15	D	d	NN
cord-281188-0cql96hu	321	16	-	-	HYPH
cord-281188-0cql96hu	321	17	alanine	alanine	JJ
cord-281188-0cql96hu	321	18	Rapid	rapid	JJ
cord-281188-0cql96hu	321	19	beta	beta	NN
cord-281188-0cql96hu	321	20	-	-	HYPH
cord-281188-0cql96hu	321	21	lactam	lactam	NN
cord-281188-0cql96hu	321	22	-	-	HYPH
cord-281188-0cql96hu	321	23	induced	induce	VBN
cord-281188-0cql96hu	321	24	lysis	lysis	NN
cord-281188-0cql96hu	321	25	requires	require	VBZ
cord-281188-0cql96hu	321	26	successful	successful	JJ
cord-281188-0cql96hu	321	27	assembly	assembly	NN
cord-281188-0cql96hu	321	28	of	of	IN
cord-281188-0cql96hu	321	29	the	the	DT
cord-281188-0cql96hu	321	30	cell	cell	NN
cord-281188-0cql96hu	321	31	division	division	NN
cord-281188-0cql96hu	321	32	machinery	machinery	NN
cord-281188-0cql96hu	321	33	Robust	robust	JJ
cord-281188-0cql96hu	321	34	,	,	,
cord-281188-0cql96hu	321	35	linear	linear	JJ
cord-281188-0cql96hu	321	36	correlations	correlation	NNS
cord-281188-0cql96hu	321	37	between	between	IN
cord-281188-0cql96hu	321	38	growth	growth	NN
cord-281188-0cql96hu	321	39	rates	rate	NNS
cord-281188-0cql96hu	321	40	and	and	CC
cord-281188-0cql96hu	321	41	beta	beta	NN
cord-281188-0cql96hu	321	42	-	-	HYPH
cord-281188-0cql96hu	321	43	lactam	lactam	NN
cord-281188-0cql96hu	321	44	-	-	HYPH
cord-281188-0cql96hu	321	45	mediated	mediate	VBN
cord-281188-0cql96hu	321	46	lysis	lysis	NN
cord-281188-0cql96hu	321	47	rates	rate	NNS
cord-281188-0cql96hu	322	1	The	the	DT
cord-281188-0cql96hu	322	2	mechanism	mechanism	NN
cord-281188-0cql96hu	322	3	of	of	IN
cord-281188-0cql96hu	322	4	the	the	DT
cord-281188-0cql96hu	322	5	irreversible	irreversible	JJ
cord-281188-0cql96hu	322	6	antimicrobial	antimicrobial	JJ
cord-281188-0cql96hu	322	7	effects	effect	NNS
cord-281188-0cql96hu	322	8	of	of	IN
cord-281188-0cql96hu	322	9	penicillins	penicillin	NNS
cord-281188-0cql96hu	322	10	:	:	:
cord-281188-0cql96hu	322	11	how	how	WRB
cord-281188-0cql96hu	322	12	the	the	DT
cord-281188-0cql96hu	322	13	betalactam	betalactam	NNP
cord-281188-0cql96hu	322	14	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	322	15	kill	kill	VBP
cord-281188-0cql96hu	322	16	and	and	CC
cord-281188-0cql96hu	322	17	lyse	lyse	VBP
cord-281188-0cql96hu	322	18	bacteria	bacteria	NNS
cord-281188-0cql96hu	322	19	Beta	beta	NN
cord-281188-0cql96hu	322	20	-	-	HYPH
cord-281188-0cql96hu	322	21	lactam	lactam	NN
cord-281188-0cql96hu	322	22	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	322	23	induce	induce	VBP
cord-281188-0cql96hu	322	24	a	a	DT
cord-281188-0cql96hu	322	25	lethal	lethal	JJ
cord-281188-0cql96hu	322	26	malfunctioning	malfunctioning	NN
cord-281188-0cql96hu	322	27	of	of	IN
cord-281188-0cql96hu	322	28	the	the	DT
cord-281188-0cql96hu	322	29	bacterial	bacterial	JJ
cord-281188-0cql96hu	322	30	cell	cell	NN
cord-281188-0cql96hu	322	31	wall	wall	NN
cord-281188-0cql96hu	322	32	synthesis	synthesis	NNP
cord-281188-0cql96hu	322	33	machinery	machinery	NN
cord-281188-0cql96hu	322	34	Excess	Excess	NNP
cord-281188-0cql96hu	322	35	membrane	membrane	NN
cord-281188-0cql96hu	322	36	synthesis	synthesis	NN
cord-281188-0cql96hu	322	37	drives	drive	VBZ
cord-281188-0cql96hu	322	38	a	a	DT
cord-281188-0cql96hu	322	39	primitive	primitive	JJ
cord-281188-0cql96hu	322	40	mode	mode	NN
cord-281188-0cql96hu	322	41	of	of	IN
cord-281188-0cql96hu	322	42	cell	cell	NN
cord-281188-0cql96hu	322	43	proliferation	proliferation	NN
cord-281188-0cql96hu	322	44	Evolution	evolution	NN
cord-281188-0cql96hu	322	45	of	of	IN
cord-281188-0cql96hu	322	46	cell	cell	NN
cord-281188-0cql96hu	322	47	division	division	NN
cord-281188-0cql96hu	322	48	:	:	:
cord-281188-0cql96hu	322	49	from	from	IN
cord-281188-0cql96hu	322	50	shear	shear	NN
cord-281188-0cql96hu	322	51	mechanics	mechanic	NNS
cord-281188-0cql96hu	322	52	to	to	IN
cord-281188-0cql96hu	322	53	complex	complex	JJ
cord-281188-0cql96hu	322	54	molecular	molecular	JJ
cord-281188-0cql96hu	322	55	machineries	machinery	NNS
cord-281188-0cql96hu	322	56	Structural	structural	JJ
cord-281188-0cql96hu	322	57	basis	basis	NN
cord-281188-0cql96hu	322	58	for	for	IN
cord-281188-0cql96hu	322	59	the	the	DT
cord-281188-0cql96hu	322	60	coordination	coordination	NN
cord-281188-0cql96hu	322	61	of	of	IN
cord-281188-0cql96hu	322	62	cell	cell	NN
cord-281188-0cql96hu	322	63	division	division	NN
cord-281188-0cql96hu	322	64	with	with	IN
cord-281188-0cql96hu	322	65	the	the	DT
cord-281188-0cql96hu	322	66	synthesis	synthesis	NN
cord-281188-0cql96hu	322	67	of	of	IN
cord-281188-0cql96hu	322	68	the	the	DT
cord-281188-0cql96hu	322	69	bacterial	bacterial	JJ
cord-281188-0cql96hu	322	70	cell	cell	NN
cord-281188-0cql96hu	322	71	envelope	envelope	NN
cord-281188-0cql96hu	323	1	Mutual	mutual	JJ
cord-281188-0cql96hu	323	2	potentiation	potentiation	NN
cord-281188-0cql96hu	323	3	drives	drive	VBZ
cord-281188-0cql96hu	323	4	synergy	synergy	NN
cord-281188-0cql96hu	323	5	between	between	IN
cord-281188-0cql96hu	323	6	trimethoprim	trimethoprim	NNP
cord-281188-0cql96hu	323	7	and	and	CC
cord-281188-0cql96hu	323	8	sulfamethoxazole	sulfamethoxazole	NNP
cord-281188-0cql96hu	323	9	Glycopeptide	Glycopeptide	NNP
cord-281188-0cql96hu	323	10	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	323	11	:	:	:
cord-281188-0cql96hu	323	12	from	from	IN
cord-281188-0cql96hu	323	13	conventional	conventional	JJ
cord-281188-0cql96hu	323	14	molecules	molecule	NNS
cord-281188-0cql96hu	323	15	to	to	IN
cord-281188-0cql96hu	323	16	new	new	JJ
cord-281188-0cql96hu	323	17	derivatives	derivative	NNS
cord-281188-0cql96hu	323	18	Lack	lack	NN
cord-281188-0cql96hu	323	19	of	of	IN
cord-281188-0cql96hu	323	20	bactericidal	bactericidal	JJ
cord-281188-0cql96hu	323	21	antagonism	antagonism	NN
cord-281188-0cql96hu	323	22	or	or	CC
cord-281188-0cql96hu	323	23	synergism	synergism	NN
cord-281188-0cql96hu	323	24	in	in	IN
cord-281188-0cql96hu	323	25	vitro	vitro	FW
cord-281188-0cql96hu	323	26	between	between	IN
cord-281188-0cql96hu	323	27	oxacillin	oxacillin	NN
cord-281188-0cql96hu	323	28	and	and	CC
cord-281188-0cql96hu	323	29	vancomycin	vancomycin	NNP
cord-281188-0cql96hu	323	30	against	against	IN
cord-281188-0cql96hu	323	31	methicillinsusceptible	methicillinsusceptible	JJ
cord-281188-0cql96hu	323	32	strains	strain	NNS
cord-281188-0cql96hu	323	33	of	of	IN
cord-281188-0cql96hu	323	34	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	323	35	aureus	aureus	NN
cord-281188-0cql96hu	324	1	Novel	novel	JJ
cord-281188-0cql96hu	324	2	mechanism	mechanism	NN
cord-281188-0cql96hu	324	3	of	of	IN
cord-281188-0cql96hu	324	4	antibiotic	antibiotic	JJ
cord-281188-0cql96hu	324	5	resistance	resistance	NN
cord-281188-0cql96hu	324	6	originating	originate	VBG
cord-281188-0cql96hu	324	7	in	in	IN
cord-281188-0cql96hu	324	8	vancomycin	vancomycin	NN
cord-281188-0cql96hu	324	9	-	-	HYPH
cord-281188-0cql96hu	324	10	intermediate	intermediate	JJ
cord-281188-0cql96hu	324	11	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	324	12	aureus	aureus	NN
cord-281188-0cql96hu	325	1	The	the	DT
cord-281188-0cql96hu	325	2	concentration	concentration	NN
cord-281188-0cql96hu	325	3	-	-	HYPH
cord-281188-0cql96hu	325	4	independent	independent	JJ
cord-281188-0cql96hu	325	5	effect	effect	NN
cord-281188-0cql96hu	325	6	of	of	IN
cord-281188-0cql96hu	325	7	monoexponential	monoexponential	JJ
cord-281188-0cql96hu	325	8	and	and	CC
cord-281188-0cql96hu	325	9	biexponential	biexponential	JJ
cord-281188-0cql96hu	325	10	decay	decay	NN
cord-281188-0cql96hu	325	11	in	in	IN
cord-281188-0cql96hu	325	12	vancomycin	vancomycin	NN
cord-281188-0cql96hu	325	13	concentrations	concentration	NNS
cord-281188-0cql96hu	325	14	on	on	IN
cord-281188-0cql96hu	325	15	the	the	DT
cord-281188-0cql96hu	325	16	killing	killing	NN
cord-281188-0cql96hu	325	17	of	of	IN
cord-281188-0cql96hu	325	18	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	325	19	aureus	aureus	NN
cord-281188-0cql96hu	325	20	under	under	IN
cord-281188-0cql96hu	325	21	aerobic	aerobic	JJ
cord-281188-0cql96hu	325	22	and	and	CC
cord-281188-0cql96hu	325	23	anaerobic	anaerobic	JJ
cord-281188-0cql96hu	325	24	conditions	condition	NNS
cord-281188-0cql96hu	325	25	Analysis	Analysis	NNP
cord-281188-0cql96hu	325	26	of	of	IN
cord-281188-0cql96hu	325	27	the	the	DT
cord-281188-0cql96hu	325	28	tolerance	tolerance	NN
cord-281188-0cql96hu	325	29	of	of	IN
cord-281188-0cql96hu	325	30	pathogenic	pathogenic	JJ
cord-281188-0cql96hu	325	31	enterococci	enterococci	NNS
cord-281188-0cql96hu	325	32	and	and	CC
cord-281188-0cql96hu	325	33	Staphylococcus	Staphylococcus	NNP
cord-281188-0cql96hu	325	34	aureus	aureus	NN
cord-281188-0cql96hu	325	35	to	to	IN
cord-281188-0cql96hu	325	36	cell	cell	NN
cord-281188-0cql96hu	325	37	wall	wall	NN
cord-281188-0cql96hu	325	38	active	active	JJ
cord-281188-0cql96hu	325	39	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	325	40	Bactericidal	bactericidal	JJ
cord-281188-0cql96hu	325	41	activity	activity	NN
cord-281188-0cql96hu	325	42	of	of	IN
cord-281188-0cql96hu	325	43	trimethoprim	trimethoprim	NN
cord-281188-0cql96hu	325	44	alone	alone	RB
cord-281188-0cql96hu	325	45	and	and	CC
cord-281188-0cql96hu	325	46	in	in	IN
cord-281188-0cql96hu	325	47	combination	combination	NN
cord-281188-0cql96hu	325	48	with	with	IN
cord-281188-0cql96hu	325	49	sulfamethoxazole	sulfamethoxazole	NNP
cord-281188-0cql96hu	325	50	on	on	IN
cord-281188-0cql96hu	325	51	susceptible	susceptible	JJ
cord-281188-0cql96hu	325	52	and	and	CC
cord-281188-0cql96hu	325	53	resistant	resistant	JJ
cord-281188-0cql96hu	325	54	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	325	55	coli	coli	VBZ
cord-281188-0cql96hu	325	56	K-12	K-12	NNP
cord-281188-0cql96hu	325	57	Nature	Nature	NNP
cord-281188-0cql96hu	325	58	of	of	IN
cord-281188-0cql96hu	325	59	the	the	DT
cord-281188-0cql96hu	325	60	bacterial	bacterial	JJ
cord-281188-0cql96hu	325	61	action	action	NN
cord-281188-0cql96hu	325	62	of	of	IN
cord-281188-0cql96hu	325	63	sulfonamides	sulfonamide	NNS
cord-281188-0cql96hu	325	64	and	and	CC
cord-281188-0cql96hu	325	65	trimethoprim	trimethoprim	NNP
cord-281188-0cql96hu	325	66	,	,	,
cord-281188-0cql96hu	325	67	alone	alone	JJ
cord-281188-0cql96hu	325	68	and	and	CC
cord-281188-0cql96hu	325	69	in	in	IN
cord-281188-0cql96hu	325	70	combination	combination	NN
cord-281188-0cql96hu	325	71	Thymine	thymine	NN
cord-281188-0cql96hu	325	72	metabolism	metabolism	NN
cord-281188-0cql96hu	325	73	and	and	CC
cord-281188-0cql96hu	325	74	thymineless	thymineless	NN
cord-281188-0cql96hu	325	75	death	death	NN
cord-281188-0cql96hu	325	76	in	in	IN
cord-281188-0cql96hu	325	77	prokaryotes	prokaryote	NNS
cord-281188-0cql96hu	325	78	and	and	CC
cord-281188-0cql96hu	325	79	eukaryotes	eukaryote	NNS
cord-281188-0cql96hu	326	1	Thymineless	thymineless	JJ
cord-281188-0cql96hu	326	2	death	death	NN
cord-281188-0cql96hu	326	3	in	in	IN
cord-281188-0cql96hu	326	4	Escherichia	Escherichia	NNP
cord-281188-0cql96hu	326	5	coli	coli	NNS
cord-281188-0cql96hu	326	6	is	be	VBZ
cord-281188-0cql96hu	326	7	unaffected	unaffected	JJ
cord-281188-0cql96hu	326	8	by	by	IN
cord-281188-0cql96hu	326	9	chromosomal	chromosomal	JJ
cord-281188-0cql96hu	326	10	replication	replication	NN
cord-281188-0cql96hu	326	11	complexity	complexity	NN
cord-281188-0cql96hu	327	1	The	the	DT
cord-281188-0cql96hu	327	2	authors	author	NNS
cord-281188-0cql96hu	327	3	are	be	VBP
cord-281188-0cql96hu	327	4	grateful	grateful	JJ
cord-281188-0cql96hu	327	5	to	to	IN
cord-281188-0cql96hu	327	6	their	-PRON-	PRP$
cord-281188-0cql96hu	327	7	awesome	awesome	JJ
cord-281188-0cql96hu	327	8	wives	wife	NNS
cord-281188-0cql96hu	327	9	,	,	,
cord-281188-0cql96hu	327	10	Ros	Ros	NNP
cord-281188-0cql96hu	327	11	and	and	CC
cord-281188-0cql96hu	327	12	Adriana	Adriana	NNP
cord-281188-0cql96hu	327	13	,	,	,
cord-281188-0cql96hu	327	14	for	for	IN
cord-281188-0cql96hu	327	15	putting	put	VBG
cord-281188-0cql96hu	327	16	up	up	RP
cord-281188-0cql96hu	327	17	with	with	IN
cord-281188-0cql96hu	327	18	them	-PRON-	PRP
cord-281188-0cql96hu	327	19	during	during	IN
cord-281188-0cql96hu	327	20	this	this	DT
cord-281188-0cql96hu	327	21	period	period	NN
cord-281188-0cql96hu	327	22	of	of	IN
cord-281188-0cql96hu	327	23	COVID-19	covid-19	JJ
cord-281188-0cql96hu	327	24	quarantine	quarantine	NN
cord-281188-0cql96hu	327	25	and	and	CC
cord-281188-0cql96hu	327	26	supporting	support	VBG
cord-281188-0cql96hu	327	27	their	-PRON-	PRP$
cord-281188-0cql96hu	327	28	playing	play	VBG
cord-281188-0cql96hu	327	29	fun	fun	NN
cord-281188-0cql96hu	327	30	games	game	NNS
cord-281188-0cql96hu	327	31	such	such	JJ
cord-281188-0cql96hu	327	32	as	as	IN
cord-281188-0cql96hu	327	33	reviewing	review	VBG
cord-281188-0cql96hu	327	34	the	the	DT
cord-281188-0cql96hu	327	35	literature	literature	NN
cord-281188-0cql96hu	327	36	and	and	CC
cord-281188-0cql96hu	327	37	writing	write	VBG
cord-281188-0cql96hu	327	38	this	this	DT
cord-281188-0cql96hu	327	39	Perspective	perspective	NN
cord-281188-0cql96hu	327	40	.	.	.
cord-281188-0cql96hu	328	1	They	-PRON-	PRP
cord-281188-0cql96hu	328	2	thank	thank	VBP
cord-281188-0cql96hu	328	3	I.	I.	NNP
cord-281188-0cql96hu	328	4	McCall	McCall	NNP
cord-281188-0cql96hu	328	5	for	for	IN
cord-281188-0cql96hu	328	6	a	a	DT
cord-281188-0cql96hu	328	7	careful	careful	JJ
cord-281188-0cql96hu	328	8	reading	reading	NN
cord-281188-0cql96hu	328	9	of	of	IN
cord-281188-0cql96hu	328	10	this	this	DT
cord-281188-0cql96hu	328	11	manuscript	manuscript	NN
cord-281188-0cql96hu	328	12	,	,	,
cord-281188-0cql96hu	328	13	and	and	CC
cord-281188-0cql96hu	328	14	J.	J.	NNP
cord-281188-0cql96hu	328	15	Rodríguez	Rodríguez	NNP
cord-281188-0cql96hu	328	16	-	-	HYPH
cord-281188-0cql96hu	328	17	Beltrán	Beltrán	NNP
cord-281188-0cql96hu	328	18	for	for	IN
cord-281188-0cql96hu	328	19	discussion	discussion	NN
cord-281188-0cql96hu	328	20	about	about	IN
cord-281188-0cql96hu	328	21	some	some	DT
cord-281188-0cql96hu	328	22	critical	critical	JJ
cord-281188-0cql96hu	328	23	concepts	concept	NNS
cord-281188-0cql96hu	328	24	.	.	.
cord-281188-0cql96hu	329	1	This	this	DT
cord-281188-0cql96hu	329	2	research	research	NN
cord-281188-0cql96hu	329	3	was	be	VBD
cord-281188-0cql96hu	329	4	funded	fund	VBN
cord-281188-0cql96hu	329	5	by	by	IN
cord-281188-0cql96hu	329	6	grants	grant	NNS
cord-281188-0cql96hu	329	7	from	from	IN
cord-281188-0cql96hu	329	8	the	the	DT
cord-281188-0cql96hu	329	9	U.S.	U.S.	NNP
cord-281188-0cql96hu	329	10	National	National	NNP
cord-281188-0cql96hu	329	11	Institutes	Institutes	NNPS
cord-281188-0cql96hu	329	12	of	of	IN
cord-281188-0cql96hu	329	13	General	General	NNP
cord-281188-0cql96hu	329	14	Medical	Medical	NNP
cord-281188-0cql96hu	329	15	Science	Science	NNP
cord-281188-0cql96hu	330	1	(	(	-LRB-
cord-281188-0cql96hu	330	2	GM091875	gm091875	NN
cord-281188-0cql96hu	330	3	-	-	HYPH
cord-281188-0cql96hu	330	4	17	17	CD
cord-281188-0cql96hu	330	5	and	and	CC
cord-281188-0cql96hu	330	6	1R35	1r35	CD
cord-281188-0cql96hu	331	1	GM136407	GM136407	NNP
cord-281188-0cql96hu	331	2	-	-	HYPH
cord-281188-0cql96hu	331	3	01	01	CD
cord-281188-0cql96hu	331	4	)	)	-RRB-
cord-281188-0cql96hu	331	5	to	to	IN
cord-281188-0cql96hu	331	6	B.R.L	B.R.L	NNP
cord-281188-0cql96hu	331	7	and	and	CC
cord-281188-0cql96hu	331	8	from	from	IN
cord-281188-0cql96hu	331	9	the	the	DT
cord-281188-0cql96hu	331	10	Regional	Regional	NNP
cord-281188-0cql96hu	331	11	Government	Government	NNP
cord-281188-0cql96hu	331	12	of	of	IN
cord-281188-0cql96hu	331	13	Madrid	Madrid	NNP
cord-281188-0cql96hu	331	14	(	(	-LRB-
cord-281188-0cql96hu	331	15	InGeMICS	InGeMICS	NNP
cord-281188-0cql96hu	331	16	-	-	HYPH
cord-281188-0cql96hu	331	17	B2017	B2017	NNP
cord-281188-0cql96hu	331	18	/	/	SYM
cord-281188-0cql96hu	331	19	BMD-3691	BMD-3691	NNP
cord-281188-0cql96hu	331	20	)	)	-RRB-
cord-281188-0cql96hu	331	21	and	and	CC
cord-281188-0cql96hu	331	22	the	the	DT
cord-281188-0cql96hu	331	23	Ramón	Ramón	NNP
cord-281188-0cql96hu	331	24	Areces	Areces	NNP
cord-281188-0cql96hu	331	25	Foundation	Foundation	NNP
cord-281188-0cql96hu	331	26	to	to	IN
cord-281188-0cql96hu	331	27	the	the	DT
cord-281188-0cql96hu	331	28	F.B.	F.B.	NNP
cord-281188-0cql96hu	331	29	laboratory	laboratory	NN
cord-281188-0cql96hu	331	30	.	.	.
cord-281188-0cql96hu	332	1	The	the	DT
cord-281188-0cql96hu	332	2	authors	author	NNS
cord-281188-0cql96hu	332	3	dedicate	dedicate	VBP
cord-281188-0cql96hu	332	4	this	this	DT
cord-281188-0cql96hu	332	5	Perspective	perspective	NN
cord-281188-0cql96hu	332	6	to	to	IN
cord-281188-0cql96hu	332	7	the	the	DT
cord-281188-0cql96hu	332	8	memory	memory	NN
cord-281188-0cql96hu	332	9	of	of	IN
cord-281188-0cql96hu	332	10	J.	J.	NNP
cord-281188-0cql96hu	332	11	Acar	Acar	NNP
cord-281188-0cql96hu	332	12	137	137	CD
cord-281188-0cql96hu	332	13	,	,	,
cord-281188-0cql96hu	332	14	with	with	IN
cord-281188-0cql96hu	332	15	whom	whom	WP
cord-281188-0cql96hu	332	16	they	-PRON-	PRP
cord-281188-0cql96hu	332	17	would	would	MD
cord-281188-0cql96hu	332	18	have	have	VB
cord-281188-0cql96hu	332	19	loved	love	VBN
cord-281188-0cql96hu	332	20	to	to	TO
cord-281188-0cql96hu	332	21	have	have	VB
cord-281188-0cql96hu	332	22	discussed	discuss	VBN
cord-281188-0cql96hu	332	23	the	the	DT
cord-281188-0cql96hu	332	24	question	question	NN
cord-281188-0cql96hu	332	25	of	of	IN
cord-281188-0cql96hu	332	26	how	how	WRB
cord-281188-0cql96hu	332	27	antibiotics	antibiotic	NNS
cord-281188-0cql96hu	332	28	kill	kill	VBP
cord-281188-0cql96hu	332	29	;	;	:
cord-281188-0cql96hu	332	30	from	from	IN
cord-281188-0cql96hu	332	31	those	those	DT
cord-281188-0cql96hu	332	32	conversations	conversation	NNS
cord-281188-0cql96hu	332	33	with	with	IN
cord-281188-0cql96hu	332	34	Jacques	Jacques	NNP
cord-281188-0cql96hu	332	35	,	,	,
cord-281188-0cql96hu	332	36	the	the	DT
cord-281188-0cql96hu	332	37	authors	author	NNS
cord-281188-0cql96hu	332	38	know	know	VBP
cord-281188-0cql96hu	332	39	they	-PRON-	PRP
cord-281188-0cql96hu	332	40	would	would	MD
cord-281188-0cql96hu	332	41	have	have	VB
cord-281188-0cql96hu	332	42	had	have	VBN
cord-281188-0cql96hu	332	43	much	much	RB
cord-281188-0cql96hu	332	44	more	more	JJR
cord-281188-0cql96hu	332	45	to	to	TO
cord-281188-0cql96hu	332	46	tell	tell	VB
cord-281188-0cql96hu	332	47	you	-PRON-	PRP
cord-281188-0cql96hu	332	48	about	about	IN
cord-281188-0cql96hu	332	49	the	the	DT
cord-281188-0cql96hu	332	50	answer	answer	NN
cord-281188-0cql96hu	332	51	.	.	.
cord-281188-0cql96hu	333	1	The	the	DT
cord-281188-0cql96hu	333	2	authors	author	NNS
cord-281188-0cql96hu	333	3	contributed	contribute	VBD
cord-281188-0cql96hu	333	4	equally	equally	RB
cord-281188-0cql96hu	333	5	to	to	IN
cord-281188-0cql96hu	333	6	all	all	DT
cord-281188-0cql96hu	333	7	aspects	aspect	NNS
cord-281188-0cql96hu	333	8	of	of	IN
cord-281188-0cql96hu	333	9	the	the	DT
cord-281188-0cql96hu	333	10	article	article	NN
cord-281188-0cql96hu	333	11	.	.	.
cord-281188-0cql96hu	334	1	The	the	DT
cord-281188-0cql96hu	334	2	authors	author	NNS
cord-281188-0cql96hu	334	3	declare	declare	VBP
cord-281188-0cql96hu	334	4	no	no	DT
cord-281188-0cql96hu	334	5	competing	compete	VBG
cord-281188-0cql96hu	334	6	interests	interest	NNS
cord-281188-0cql96hu	334	7	.	.	.
cord-281188-0cql96hu	335	1	Nature	Nature	NNP
cord-281188-0cql96hu	335	2	Reviews	Reviews	NNPS
cord-281188-0cql96hu	335	3	Microbiology	Microbiology	NNP
cord-281188-0cql96hu	335	4	thanks	thank	NNS
cord-281188-0cql96hu	336	1	the	the	DT
cord-281188-0cql96hu	336	2	anonymous	anonymous	NNP
cord-281188-0cql96hu	336	3	reviewer(s	reviewer(s	NNP
cord-281188-0cql96hu	336	4	)	)	-RRB-
cord-281188-0cql96hu	336	5	for	for	IN
cord-281188-0cql96hu	336	6	their	-PRON-	PRP$
cord-281188-0cql96hu	336	7	contribution	contribution	NN
cord-281188-0cql96hu	336	8	to	to	IN
cord-281188-0cql96hu	336	9	the	the	DT
cord-281188-0cql96hu	336	10	peer	peer	NN
cord-281188-0cql96hu	336	11	review	review	NN
cord-281188-0cql96hu	336	12	of	of	IN
cord-281188-0cql96hu	336	13	this	this	DT
cord-281188-0cql96hu	336	14	work	work	NN
cord-281188-0cql96hu	336	15	.	.	.
cord-281188-0cql96hu	337	1	Springer	Springer	NNP
cord-281188-0cql96hu	337	2	Nature	Nature	NNP
cord-281188-0cql96hu	337	3	remains	remain	VBZ
cord-281188-0cql96hu	337	4	neutral	neutral	JJ
cord-281188-0cql96hu	337	5	with	with	IN
cord-281188-0cql96hu	337	6	regard	regard	NN
cord-281188-0cql96hu	337	7	to	to	IN
cord-281188-0cql96hu	337	8	jurisdictional	jurisdictional	JJ
cord-281188-0cql96hu	337	9	claims	claim	NNS
cord-281188-0cql96hu	337	10	in	in	IN
cord-281188-0cql96hu	337	11	published	publish	VBN
cord-281188-0cql96hu	337	12	maps	map	NNS
cord-281188-0cql96hu	337	13	and	and	CC
cord-281188-0cql96hu	337	14	institutional	institutional	JJ
cord-281188-0cql96hu	337	15	affiliations	affiliation	NNS
cord-281188-0cql96hu	337	16	.	.	.