id	sid	tid	token	lemma	pos
cord-021419-nypnib0h	1	1	key	key	NN
cord-021419-nypnib0h	1	2	:	:	:
cord-021419-nypnib0h	2	1	cord-021419-nypnib0h	cord-021419-nypnib0h	NN
cord-021419-nypnib0h	2	2	authors	author	NNS
cord-021419-nypnib0h	2	3	:	:	:
cord-021419-nypnib0h	2	4	Olsufyeva	Olsufyeva	NNP
cord-021419-nypnib0h	2	5	,	,	,
cord-021419-nypnib0h	2	6	Evgenia	Evgenia	NNP
cord-021419-nypnib0h	2	7	N.	N.	NNP
cord-021419-nypnib0h	2	8	;	;	:
cord-021419-nypnib0h	2	9	Yankovskaya	Yankovskaya	NNP
cord-021419-nypnib0h	2	10	,	,	,
cord-021419-nypnib0h	2	11	Valentina	Valentina	NNP
cord-021419-nypnib0h	2	12	S.	S.	NNP
cord-021419-nypnib0h	3	1	title	title	NN
cord-021419-nypnib0h	3	2	:	:	:
cord-021419-nypnib0h	4	1	Main	main	JJ
cord-021419-nypnib0h	4	2	trends	trend	NNS
cord-021419-nypnib0h	4	3	in	in	IN
cord-021419-nypnib0h	4	4	the	the	DT
cord-021419-nypnib0h	4	5	design	design	NN
cord-021419-nypnib0h	4	6	of	of	IN
cord-021419-nypnib0h	4	7	semi	semi	JJ
cord-021419-nypnib0h	4	8	-	-	JJ
cord-021419-nypnib0h	4	9	synthetic	synthetic	JJ
cord-021419-nypnib0h	4	10	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	4	11	of	of	IN
cord-021419-nypnib0h	4	12	a	a	DT
cord-021419-nypnib0h	4	13	new	new	JJ
cord-021419-nypnib0h	4	14	generation	generation	NN
cord-021419-nypnib0h	4	15	date	date	NN
cord-021419-nypnib0h	4	16	:	:	:
cord-021419-nypnib0h	4	17	2020	2020	CD
cord-021419-nypnib0h	4	18	-	-	HYPH
cord-021419-nypnib0h	4	19	03	03	CD
cord-021419-nypnib0h	4	20	-	-	SYM
cord-021419-nypnib0h	4	21	17	17	CD
cord-021419-nypnib0h	4	22	journal	journal	NN
cord-021419-nypnib0h	4	23	:	:	:
cord-021419-nypnib0h	5	1	nan	nan	NNP
cord-021419-nypnib0h	5	2	DOI	DOI	NNP
cord-021419-nypnib0h	5	3	:	:	:
cord-021419-nypnib0h	5	4	10.1070	10.1070	CD
cord-021419-nypnib0h	5	5	/	/	SYM
cord-021419-nypnib0h	5	6	rcr4892	rcr4892	NN
cord-021419-nypnib0h	5	7	sha	sha	NNP
cord-021419-nypnib0h	5	8	:	:	:
cord-021419-nypnib0h	6	1	0bd206c313f628703bf896ecb80d2a37e1a178a3	0bd206c313f628703bf896ecb80d2a37e1a178a3	CD
cord-021419-nypnib0h	6	2	doc_id	doc_id	CD
cord-021419-nypnib0h	6	3	:	:	:
cord-021419-nypnib0h	7	1	21419	21419	CD
cord-021419-nypnib0h	7	2	cord_uid	cord_uid	NNS
cord-021419-nypnib0h	7	3	:	:	:
cord-021419-nypnib0h	7	4	nypnib0h	nypnib0h	NNP
cord-021419-nypnib0h	8	1	This	this	DT
cord-021419-nypnib0h	8	2	review	review	NN
cord-021419-nypnib0h	8	3	summarizes	summarize	VBZ
cord-021419-nypnib0h	8	4	main	main	JJ
cord-021419-nypnib0h	8	5	advances	advance	NNS
cord-021419-nypnib0h	8	6	achieved	achieve	VBN
cord-021419-nypnib0h	8	7	by	by	IN
cord-021419-nypnib0h	8	8	Russian	russian	JJ
cord-021419-nypnib0h	8	9	researchers	researcher	NNS
cord-021419-nypnib0h	8	10	in	in	IN
cord-021419-nypnib0h	8	11	the	the	DT
cord-021419-nypnib0h	8	12	synthesis	synthesis	NN
cord-021419-nypnib0h	8	13	and	and	CC
cord-021419-nypnib0h	8	14	characterization	characterization	NN
cord-021419-nypnib0h	8	15	of	of	IN
cord-021419-nypnib0h	8	16	semi	semi	JJ
cord-021419-nypnib0h	8	17	-	-	JJ
cord-021419-nypnib0h	8	18	synthetic	synthetic	JJ
cord-021419-nypnib0h	8	19	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	8	20	of	of	IN
cord-021419-nypnib0h	8	21	a	a	DT
cord-021419-nypnib0h	8	22	new	new	JJ
cord-021419-nypnib0h	8	23	generation	generation	NN
cord-021419-nypnib0h	8	24	in	in	IN
cord-021419-nypnib0h	8	25	the	the	DT
cord-021419-nypnib0h	8	26	period	period	NN
cord-021419-nypnib0h	8	27	from	from	IN
cord-021419-nypnib0h	8	28	2004	2004	CD
cord-021419-nypnib0h	8	29	to	to	IN
cord-021419-nypnib0h	8	30	2019	2019	CD
cord-021419-nypnib0h	8	31	.	.	.
cord-021419-nypnib0h	9	1	The	the	DT
cord-021419-nypnib0h	9	2	following	follow	VBG
cord-021419-nypnib0h	9	3	classes	class	NNS
cord-021419-nypnib0h	9	4	of	of	IN
cord-021419-nypnib0h	9	5	compounds	compound	NNS
cord-021419-nypnib0h	9	6	are	be	VBP
cord-021419-nypnib0h	9	7	considered	consider	VBN
cord-021419-nypnib0h	9	8	as	as	IN
cord-021419-nypnib0h	9	9	the	the	DT
cord-021419-nypnib0h	9	10	basis	basis	NN
cord-021419-nypnib0h	9	11	for	for	IN
cord-021419-nypnib0h	9	12	modification	modification	NN
cord-021419-nypnib0h	9	13	:	:	:
cord-021419-nypnib0h	9	14	polycyclic	polycyclic	JJ
cord-021419-nypnib0h	9	15	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	9	16	glycopeptides	glycopeptide	NNS
cord-021419-nypnib0h	9	17	of	of	IN
cord-021419-nypnib0h	9	18	the	the	DT
cord-021419-nypnib0h	9	19	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	9	20	group	group	NN
cord-021419-nypnib0h	9	21	,	,	,
cord-021419-nypnib0h	9	22	classical	classical	JJ
cord-021419-nypnib0h	9	23	macrolides	macrolide	NNS
cord-021419-nypnib0h	9	24	,	,	,
cord-021419-nypnib0h	9	25	antifungal	antifungal	JJ
cord-021419-nypnib0h	9	26	polyene	polyene	NNP
cord-021419-nypnib0h	9	27	macrolides	macrolide	NNS
cord-021419-nypnib0h	9	28	,	,	,
cord-021419-nypnib0h	9	29	the	the	DT
cord-021419-nypnib0h	9	30	antitumour	antitumour	JJ
cord-021419-nypnib0h	9	31	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	9	32	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	9	33	A	A	NNP
cord-021419-nypnib0h	9	34	,	,	,
cord-021419-nypnib0h	9	35	antitumour	antitumour	NNP
cord-021419-nypnib0h	9	36	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	9	37	and	and	CC
cord-021419-nypnib0h	9	38	broad	broad	JJ
cord-021419-nypnib0h	9	39	-	-	HYPH
cord-021419-nypnib0h	9	40	spectrum	spectrum	NN
cord-021419-nypnib0h	9	41	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	9	42	,	,	,
cord-021419-nypnib0h	9	43	in	in	IN
cord-021419-nypnib0h	9	44	particular	particular	JJ
cord-021419-nypnib0h	9	45	,	,	,
cord-021419-nypnib0h	9	46	oligomycin	oligomycin	VBZ
cord-021419-nypnib0h	9	47	A	A	NNP
cord-021419-nypnib0h	9	48	,	,	,
cord-021419-nypnib0h	9	49	heliomycin	heliomycin	NNS
cord-021419-nypnib0h	9	50	and	and	CC
cord-021419-nypnib0h	9	51	some	some	DT
cord-021419-nypnib0h	9	52	other	other	JJ
cord-021419-nypnib0h	9	53	.	.	.
cord-021419-nypnib0h	10	1	Main	main	JJ
cord-021419-nypnib0h	10	2	trends	trend	NNS
cord-021419-nypnib0h	10	3	in	in	IN
cord-021419-nypnib0h	10	4	the	the	DT
cord-021419-nypnib0h	10	5	design	design	NN
cord-021419-nypnib0h	10	6	of	of	IN
cord-021419-nypnib0h	10	7	modern	modern	JJ
cord-021419-nypnib0h	10	8	anti	anti	JJ
cord-021419-nypnib0h	10	9	-	-	JJ
cord-021419-nypnib0h	10	10	infective	infective	JJ
cord-021419-nypnib0h	10	11	and	and	CC
cord-021419-nypnib0h	10	12	antitumour	antitumour	JJ
cord-021419-nypnib0h	10	13	agents	agent	NNS
cord-021419-nypnib0h	10	14	over	over	IN
cord-021419-nypnib0h	10	15	this	this	DT
cord-021419-nypnib0h	10	16	period	period	NN
cord-021419-nypnib0h	10	17	are	be	VBP
cord-021419-nypnib0h	10	18	considered	consider	VBN
cord-021419-nypnib0h	10	19	in	in	IN
cord-021419-nypnib0h	10	20	relation	relation	NN
cord-021419-nypnib0h	10	21	to	to	IN
cord-021419-nypnib0h	10	22	original	original	JJ
cord-021419-nypnib0h	10	23	natural	natural	JJ
cord-021419-nypnib0h	10	24	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	10	25	,	,	,
cord-021419-nypnib0h	10	26	which	which	WDT
cord-021419-nypnib0h	10	27	have	have	VBP
cord-021419-nypnib0h	10	28	been	be	VBN
cord-021419-nypnib0h	10	29	independently	independently	RB
cord-021419-nypnib0h	10	30	discovered	discover	VBN
cord-021419-nypnib0h	10	31	by	by	IN
cord-021419-nypnib0h	10	32	Russian	russian	JJ
cord-021419-nypnib0h	10	33	researchers	researcher	NNS
cord-021419-nypnib0h	10	34	.	.	.
cord-021419-nypnib0h	11	1	It	-PRON-	PRP
cord-021419-nypnib0h	11	2	is	be	VBZ
cord-021419-nypnib0h	11	3	shown	show	VBN
cord-021419-nypnib0h	11	4	that	that	IN
cord-021419-nypnib0h	11	5	a	a	DT
cord-021419-nypnib0h	11	6	new	new	JJ
cord-021419-nypnib0h	11	7	type	type	NN
cord-021419-nypnib0h	11	8	of	of	IN
cord-021419-nypnib0h	11	9	hybrid	hybrid	JJ
cord-021419-nypnib0h	11	10	structures	structure	NNS
cord-021419-nypnib0h	11	11	can	can	MD
cord-021419-nypnib0h	11	12	,	,	,
cord-021419-nypnib0h	11	13	in	in	IN
cord-021419-nypnib0h	11	14	principle	principle	NN
cord-021419-nypnib0h	11	15	,	,	,
cord-021419-nypnib0h	11	16	be	be	VB
cord-021419-nypnib0h	11	17	synthesized	synthesize	VBN
cord-021419-nypnib0h	11	18	based	base	VBN
cord-021419-nypnib0h	11	19	on	on	IN
cord-021419-nypnib0h	11	20	glycopeptides	glycopeptides	NNP
cord-021419-nypnib0h	11	21	,	,	,
cord-021419-nypnib0h	11	22	macrolides	macrolide	NNS
cord-021419-nypnib0h	11	23	and	and	CC
cord-021419-nypnib0h	11	24	other	other	JJ
cord-021419-nypnib0h	11	25	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	11	26	,	,	,
cord-021419-nypnib0h	11	27	including	include	VBG
cord-021419-nypnib0h	11	28	heterodimers	heterodimer	NNS
cord-021419-nypnib0h	11	29	containing	contain	VBG
cord-021419-nypnib0h	11	30	a	a	DT
cord-021419-nypnib0h	11	31	new	new	JJ
cord-021419-nypnib0h	11	32	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	11	33	pharmacophore	pharmacophore	NNP
cord-021419-nypnib0h	11	34	.	.	.
cord-021419-nypnib0h	12	1	The	the	DT
cord-021419-nypnib0h	12	2	review	review	NN
cord-021419-nypnib0h	12	3	addresses	address	VBZ
cord-021419-nypnib0h	12	4	the	the	DT
cord-021419-nypnib0h	12	5	influence	influence	NN
cord-021419-nypnib0h	12	6	of	of	IN
cord-021419-nypnib0h	12	7	the	the	DT
cord-021419-nypnib0h	12	8	length	length	NN
cord-021419-nypnib0h	12	9	of	of	IN
cord-021419-nypnib0h	12	10	the	the	DT
cord-021419-nypnib0h	12	11	spacer	spacer	NN
cord-021419-nypnib0h	12	12	between	between	IN
cord-021419-nypnib0h	12	13	two	two	CD
cord-021419-nypnib0h	12	14	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	12	15	molecules	molecule	NNS
cord-021419-nypnib0h	12	16	on	on	IN
cord-021419-nypnib0h	12	17	the	the	DT
cord-021419-nypnib0h	12	18	biological	biological	JJ
cord-021419-nypnib0h	12	19	activity	activity	NN
cord-021419-nypnib0h	12	20	of	of	IN
cord-021419-nypnib0h	12	21	hybrid	hybrid	JJ
cord-021419-nypnib0h	12	22	structures	structure	NNS
cord-021419-nypnib0h	12	23	.	.	.
cord-021419-nypnib0h	13	1	A	a	DT
cord-021419-nypnib0h	13	2	combination	combination	NN
cord-021419-nypnib0h	13	3	of	of	IN
cord-021419-nypnib0h	13	4	genetic	genetic	JJ
cord-021419-nypnib0h	13	5	engineering	engineering	NN
cord-021419-nypnib0h	13	6	techniques	technique	NNS
cord-021419-nypnib0h	13	7	and	and	CC
cord-021419-nypnib0h	13	8	methods	method	NNS
cord-021419-nypnib0h	13	9	of	of	IN
cord-021419-nypnib0h	13	10	organic	organic	JJ
cord-021419-nypnib0h	13	11	synthesis	synthesis	NN
cord-021419-nypnib0h	13	12	is	be	VBZ
cord-021419-nypnib0h	13	13	shown	show	VBN
cord-021419-nypnib0h	13	14	to	to	TO
cord-021419-nypnib0h	13	15	be	be	VB
cord-021419-nypnib0h	13	16	useful	useful	JJ
cord-021419-nypnib0h	13	17	for	for	IN
cord-021419-nypnib0h	13	18	the	the	DT
cord-021419-nypnib0h	13	19	design	design	NN
cord-021419-nypnib0h	13	20	of	of	IN
cord-021419-nypnib0h	13	21	new	new	JJ
cord-021419-nypnib0h	13	22	potent	potent	JJ
cord-021419-nypnib0h	13	23	antifungal	antifungal	JJ
cord-021419-nypnib0h	13	24	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	13	25	based	base	VBN
cord-021419-nypnib0h	13	26	on	on	IN
cord-021419-nypnib0h	13	27	polyenes	polyene	NNS
cord-021419-nypnib0h	13	28	of	of	IN
cord-021419-nypnib0h	13	29	the	the	DT
cord-021419-nypnib0h	13	30	amphotericin	amphotericin	NNP
cord-021419-nypnib0h	13	31	B	B	NNP
cord-021419-nypnib0h	13	32	group	group	NN
cord-021419-nypnib0h	13	33	.	.	.
cord-021419-nypnib0h	14	1	Many	many	JJ
cord-021419-nypnib0h	14	2	new	new	JJ
cord-021419-nypnib0h	14	3	semi	semi	JJ
cord-021419-nypnib0h	14	4	-	-	JJ
cord-021419-nypnib0h	14	5	synthetic	synthetic	JJ
cord-021419-nypnib0h	14	6	analogues	analogue	NNS
cord-021419-nypnib0h	14	7	exhibit	exhibit	VB
cord-021419-nypnib0h	14	8	important	important	JJ
cord-021419-nypnib0h	14	9	biological	biological	JJ
cord-021419-nypnib0h	14	10	properties	property	NNS
cord-021419-nypnib0h	14	11	,	,	,
cord-021419-nypnib0h	14	12	such	such	JJ
cord-021419-nypnib0h	14	13	as	as	IN
cord-021419-nypnib0h	14	14	a	a	DT
cord-021419-nypnib0h	14	15	broad	broad	JJ
cord-021419-nypnib0h	14	16	spectrum	spectrum	NN
cord-021419-nypnib0h	14	17	of	of	IN
cord-021419-nypnib0h	14	18	activity	activity	NN
cord-021419-nypnib0h	14	19	and	and	CC
cord-021419-nypnib0h	14	20	low	low	JJ
cord-021419-nypnib0h	14	21	toxicity	toxicity	NN
cord-021419-nypnib0h	14	22	.	.	.
cord-021419-nypnib0h	15	1	Emphasis	emphasis	NN
cord-021419-nypnib0h	15	2	is	be	VBZ
cord-021419-nypnib0h	15	3	given	give	VBN
cord-021419-nypnib0h	15	4	to	to	IN
cord-021419-nypnib0h	15	5	certain	certain	JJ
cord-021419-nypnib0h	15	6	aspects	aspect	NNS
cord-021419-nypnib0h	15	7	related	relate	VBN
cord-021419-nypnib0h	15	8	to	to	IN
cord-021419-nypnib0h	15	9	investigation	investigation	NN
cord-021419-nypnib0h	15	10	of	of	IN
cord-021419-nypnib0h	15	11	a	a	DT
cord-021419-nypnib0h	15	12	broad	broad	JJ
cord-021419-nypnib0h	15	13	range	range	NN
cord-021419-nypnib0h	15	14	of	of	IN
cord-021419-nypnib0h	15	15	biological	biological	JJ
cord-021419-nypnib0h	15	16	activity	activity	NN
cord-021419-nypnib0h	15	17	and	and	CC
cord-021419-nypnib0h	15	18	mechanisms	mechanism	NNS
cord-021419-nypnib0h	15	19	of	of	IN
cord-021419-nypnib0h	15	20	action	action	NN
cord-021419-nypnib0h	15	21	of	of	IN
cord-021419-nypnib0h	15	22	new	new	JJ
cord-021419-nypnib0h	15	23	derivatives	derivative	NNS
cord-021419-nypnib0h	15	24	.	.	.
cord-021419-nypnib0h	16	1	The	the	DT
cord-021419-nypnib0h	16	2	bibliography	bibliography	NN
cord-021419-nypnib0h	16	3	includes	include	VBZ
cord-021419-nypnib0h	16	4	101	101	CD
cord-021419-nypnib0h	16	5	references	reference	NNS
cord-021419-nypnib0h	16	6	.	.	.
cord-021419-nypnib0h	17	1	The	the	DT
cord-021419-nypnib0h	17	2	review	review	NN
cord-021419-nypnib0h	17	3	addresses	address	VBZ
cord-021419-nypnib0h	17	4	the	the	DT
cord-021419-nypnib0h	17	5	influence	influence	NN
cord-021419-nypnib0h	17	6	of	of	IN
cord-021419-nypnib0h	17	7	the	the	DT
cord-021419-nypnib0h	17	8	length	length	NN
cord-021419-nypnib0h	17	9	of	of	IN
cord-021419-nypnib0h	17	10	the	the	DT
cord-021419-nypnib0h	17	11	spacer	spacer	NN
cord-021419-nypnib0h	17	12	between	between	IN
cord-021419-nypnib0h	17	13	two	two	CD
cord-021419-nypnib0h	17	14	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	17	15	molecules	molecule	NNS
cord-021419-nypnib0h	17	16	on	on	IN
cord-021419-nypnib0h	17	17	the	the	DT
cord-021419-nypnib0h	17	18	biological	biological	JJ
cord-021419-nypnib0h	17	19	activity	activity	NN
cord-021419-nypnib0h	17	20	of	of	IN
cord-021419-nypnib0h	17	21	hybrid	hybrid	JJ
cord-021419-nypnib0h	17	22	structures	structure	NNS
cord-021419-nypnib0h	17	23	.	.	.
cord-021419-nypnib0h	18	1	A	a	DT
cord-021419-nypnib0h	18	2	combination	combination	NN
cord-021419-nypnib0h	18	3	of	of	IN
cord-021419-nypnib0h	18	4	genetic	genetic	JJ
cord-021419-nypnib0h	18	5	engineering	engineering	NN
cord-021419-nypnib0h	18	6	techniques	technique	NNS
cord-021419-nypnib0h	18	7	and	and	CC
cord-021419-nypnib0h	18	8	methods	method	NNS
cord-021419-nypnib0h	18	9	of	of	IN
cord-021419-nypnib0h	18	10	organic	organic	JJ
cord-021419-nypnib0h	18	11	synthesis	synthesis	NN
cord-021419-nypnib0h	18	12	is	be	VBZ
cord-021419-nypnib0h	18	13	shown	show	VBN
cord-021419-nypnib0h	18	14	to	to	TO
cord-021419-nypnib0h	18	15	be	be	VB
cord-021419-nypnib0h	18	16	useful	useful	JJ
cord-021419-nypnib0h	18	17	for	for	IN
cord-021419-nypnib0h	18	18	the	the	DT
cord-021419-nypnib0h	18	19	design	design	NN
cord-021419-nypnib0h	18	20	of	of	IN
cord-021419-nypnib0h	18	21	new	new	JJ
cord-021419-nypnib0h	18	22	potent	potent	JJ
cord-021419-nypnib0h	18	23	antifungal	antifungal	JJ
cord-021419-nypnib0h	18	24	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	18	25	based	base	VBN
cord-021419-nypnib0h	18	26	on	on	IN
cord-021419-nypnib0h	18	27	polyenes	polyene	NNS
cord-021419-nypnib0h	18	28	of	of	IN
cord-021419-nypnib0h	18	29	the	the	DT
cord-021419-nypnib0h	18	30	amphotericin	amphotericin	NNP
cord-021419-nypnib0h	18	31	B	B	NNP
cord-021419-nypnib0h	18	32	group	group	NN
cord-021419-nypnib0h	18	33	.	.	.
cord-021419-nypnib0h	19	1	Many	many	JJ
cord-021419-nypnib0h	19	2	new	new	JJ
cord-021419-nypnib0h	19	3	semi	semi	JJ
cord-021419-nypnib0h	19	4	-	-	JJ
cord-021419-nypnib0h	19	5	synthetic	synthetic	JJ
cord-021419-nypnib0h	19	6	analogues	analogue	NNS
cord-021419-nypnib0h	19	7	exhibit	exhibit	VB
cord-021419-nypnib0h	19	8	important	important	JJ
cord-021419-nypnib0h	19	9	biological	biological	JJ
cord-021419-nypnib0h	19	10	properties	property	NNS
cord-021419-nypnib0h	19	11	,	,	,
cord-021419-nypnib0h	19	12	such	such	JJ
cord-021419-nypnib0h	19	13	as	as	IN
cord-021419-nypnib0h	19	14	a	a	DT
cord-021419-nypnib0h	19	15	broad	broad	JJ
cord-021419-nypnib0h	19	16	spectrum	spectrum	NN
cord-021419-nypnib0h	19	17	of	of	IN
cord-021419-nypnib0h	19	18	activity	activity	NN
cord-021419-nypnib0h	19	19	and	and	CC
cord-021419-nypnib0h	19	20	low	low	JJ
cord-021419-nypnib0h	19	21	toxicity	toxicity	NN
cord-021419-nypnib0h	19	22	.	.	.
cord-021419-nypnib0h	20	1	Emphasis	emphasis	NN
cord-021419-nypnib0h	20	2	is	be	VBZ
cord-021419-nypnib0h	20	3	given	give	VBN
cord-021419-nypnib0h	20	4	to	to	IN
cord-021419-nypnib0h	20	5	certain	certain	JJ
cord-021419-nypnib0h	20	6	aspects	aspect	NNS
cord-021419-nypnib0h	20	7	related	relate	VBN
cord-021419-nypnib0h	20	8	to	to	IN
cord-021419-nypnib0h	20	9	investigation	investigation	NN
cord-021419-nypnib0h	20	10	of	of	IN
cord-021419-nypnib0h	20	11	a	a	DT
cord-021419-nypnib0h	20	12	broad	broad	JJ
cord-021419-nypnib0h	20	13	range	range	NN
cord-021419-nypnib0h	20	14	of	of	IN
cord-021419-nypnib0h	20	15	biological	biological	JJ
cord-021419-nypnib0h	20	16	activity	activity	NN
cord-021419-nypnib0h	20	17	and	and	CC
cord-021419-nypnib0h	20	18	mechanisms	mechanism	NNS
cord-021419-nypnib0h	20	19	of	of	IN
cord-021419-nypnib0h	20	20	action	action	NN
cord-021419-nypnib0h	20	21	of	of	IN
cord-021419-nypnib0h	20	22	new	new	JJ
cord-021419-nypnib0h	20	23	derivatives	derivative	NNS
cord-021419-nypnib0h	20	24	.	.	.
cord-021419-nypnib0h	21	1	The	the	DT
cord-021419-nypnib0h	21	2	bibliography	bibliography	NN
cord-021419-nypnib0h	21	3	includes	include	VBZ
cord-021419-nypnib0h	21	4	101	101	CD
cord-021419-nypnib0h	21	5	references	reference	NNS
cord-021419-nypnib0h	21	6	.	.	.
cord-021419-nypnib0h	22	1	Antibiotics	antibiotic	NNS
cord-021419-nypnib0h	22	2	are	be	VBP
cord-021419-nypnib0h	22	3	commonly	commonly	RB
cord-021419-nypnib0h	22	4	used	use	VBN
cord-021419-nypnib0h	22	5	in	in	IN
cord-021419-nypnib0h	22	6	the	the	DT
cord-021419-nypnib0h	22	7	treatment	treatment	NN
cord-021419-nypnib0h	22	8	and	and	CC
cord-021419-nypnib0h	22	9	prevention	prevention	NN
cord-021419-nypnib0h	22	10	of	of	IN
cord-021419-nypnib0h	22	11	various	various	JJ
cord-021419-nypnib0h	22	12	infectious	infectious	JJ
cord-021419-nypnib0h	22	13	diseases	disease	NNS
cord-021419-nypnib0h	22	14	.	.	.
cord-021419-nypnib0h	23	1	One	one	CD
cord-021419-nypnib0h	23	2	of	of	IN
cord-021419-nypnib0h	23	3	the	the	DT
cord-021419-nypnib0h	23	4	major	major	JJ
cord-021419-nypnib0h	23	5	problems	problem	NNS
cord-021419-nypnib0h	23	6	of	of	IN
cord-021419-nypnib0h	23	7	modern	modern	JJ
cord-021419-nypnib0h	23	8	chemotherapy	chemotherapy	NN
cord-021419-nypnib0h	23	9	is	be	VBZ
cord-021419-nypnib0h	23	10	the	the	DT
cord-021419-nypnib0h	23	11	disappointing	disappointing	JJ
cord-021419-nypnib0h	23	12	efficacy	efficacy	NN
cord-021419-nypnib0h	23	13	when	when	WRB
cord-021419-nypnib0h	23	14	using	use	VBG
cord-021419-nypnib0h	23	15	available	available	JJ
cord-021419-nypnib0h	23	16	drugs	drug	NNS
cord-021419-nypnib0h	23	17	against	against	IN
cord-021419-nypnib0h	23	18	resistant	resistant	JJ
cord-021419-nypnib0h	23	19	bacterial	bacterial	JJ
cord-021419-nypnib0h	23	20	strains	strain	NNS
cord-021419-nypnib0h	23	21	.	.	.
cord-021419-nypnib0h	24	1	Natural	natural	JJ
cord-021419-nypnib0h	24	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	24	3	,	,	,
cord-021419-nypnib0h	24	4	i.e.	i.e.	FW
cord-021419-nypnib0h	24	5	,	,	,
cord-021419-nypnib0h	24	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	24	7	produced	produce	VBN
cord-021419-nypnib0h	24	8	by	by	IN
cord-021419-nypnib0h	24	9	various	various	JJ
cord-021419-nypnib0h	24	10	microorganisms	microorganism	NNS
cord-021419-nypnib0h	24	11	,	,	,
cord-021419-nypnib0h	24	12	have	have	VBP
cord-021419-nypnib0h	24	13	been	be	VBN
cord-021419-nypnib0h	24	14	and	and	CC
cord-021419-nypnib0h	24	15	continue	continue	VB
cord-021419-nypnib0h	24	16	to	to	TO
cord-021419-nypnib0h	24	17	be	be	VB
cord-021419-nypnib0h	24	18	an	an	DT
cord-021419-nypnib0h	24	19	important	important	JJ
cord-021419-nypnib0h	24	20	source	source	NN
cord-021419-nypnib0h	24	21	of	of	IN
cord-021419-nypnib0h	24	22	new	new	JJ
cord-021419-nypnib0h	24	23	highly	highly	RB
cord-021419-nypnib0h	24	24	active	active	JJ
cord-021419-nypnib0h	24	25	antimicrobial	antimicrobial	NN
cord-021419-nypnib0h	24	26	and	and	CC
cord-021419-nypnib0h	24	27	antitumour	antitumour	JJ
cord-021419-nypnib0h	24	28	agents	agent	NNS
cord-021419-nypnib0h	24	29	.	.	.
cord-021419-nypnib0h	25	1	One	one	CD
cord-021419-nypnib0h	25	2	of	of	IN
cord-021419-nypnib0h	25	3	the	the	DT
cord-021419-nypnib0h	25	4	most	most	RBS
cord-021419-nypnib0h	25	5	relevant	relevant	JJ
cord-021419-nypnib0h	25	6	approaches	approach	NNS
cord-021419-nypnib0h	25	7	to	to	IN
cord-021419-nypnib0h	25	8	the	the	DT
cord-021419-nypnib0h	25	9	design	design	NN
cord-021419-nypnib0h	25	10	of	of	IN
cord-021419-nypnib0h	25	11	new	new	JJ
cord-021419-nypnib0h	25	12	drugs	drug	NNS
cord-021419-nypnib0h	25	13	relies	rely	VBZ
cord-021419-nypnib0h	25	14	on	on	IN
cord-021419-nypnib0h	25	15	targeted	target	VBN
cord-021419-nypnib0h	25	16	chemical	chemical	NN
cord-021419-nypnib0h	25	17	transformations	transformation	NNS
cord-021419-nypnib0h	25	18	of	of	IN
cord-021419-nypnib0h	25	19	natural	natural	JJ
cord-021419-nypnib0h	25	20	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	25	21	.	.	.
cord-021419-nypnib0h	26	1	1	1	LS
cord-021419-nypnib0h	27	1	In	in	IN
cord-021419-nypnib0h	27	2	the	the	DT
cord-021419-nypnib0h	27	3	world	world	NN
cord-021419-nypnib0h	27	4	science	science	NN
cord-021419-nypnib0h	27	5	,	,	,
cord-021419-nypnib0h	27	6	considerable	considerable	JJ
cord-021419-nypnib0h	27	7	efforts	effort	NNS
cord-021419-nypnib0h	27	8	are	be	VBP
cord-021419-nypnib0h	27	9	currently	currently	RB
cord-021419-nypnib0h	27	10	underway	underway	JJ
cord-021419-nypnib0h	27	11	to	to	TO
cord-021419-nypnib0h	27	12	combat	combat	VB
cord-021419-nypnib0h	27	13	the	the	DT
cord-021419-nypnib0h	27	14	problem	problem	NN
cord-021419-nypnib0h	27	15	of	of	IN
cord-021419-nypnib0h	27	16	resistance	resistance	NN
cord-021419-nypnib0h	27	17	of	of	IN
cord-021419-nypnib0h	27	18	microorganisms	microorganism	NNS
cord-021419-nypnib0h	27	19	to	to	IN
cord-021419-nypnib0h	27	20	available	available	JJ
cord-021419-nypnib0h	27	21	drugs	drug	NNS
cord-021419-nypnib0h	27	22	.	.	.
cord-021419-nypnib0h	28	1	However	however	RB
cord-021419-nypnib0h	28	2	,	,	,
cord-021419-nypnib0h	28	3	in	in	IN
cord-021419-nypnib0h	28	4	comparison	comparison	NN
cord-021419-nypnib0h	28	5	with	with	IN
cord-021419-nypnib0h	28	6	other	other	JJ
cord-021419-nypnib0h	28	7	drugs	drug	NNS
cord-021419-nypnib0h	28	8	,	,	,
cord-021419-nypnib0h	28	9	the	the	DT
cord-021419-nypnib0h	28	10	development	development	NN
cord-021419-nypnib0h	28	11	of	of	IN
cord-021419-nypnib0h	28	12	new	new	JJ
cord-021419-nypnib0h	28	13	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	28	14	is	be	VBZ
cord-021419-nypnib0h	28	15	not	not	RB
cord-021419-nypnib0h	28	16	carried	carry	VBN
cord-021419-nypnib0h	28	17	out	out	RP
cord-021419-nypnib0h	28	18	sufficiently	sufficiently	RB
cord-021419-nypnib0h	28	19	.	.	.
cord-021419-nypnib0h	29	1	The	the	DT
cord-021419-nypnib0h	29	2	design	design	NN
cord-021419-nypnib0h	29	3	of	of	IN
cord-021419-nypnib0h	29	4	anti	anti	JJ
cord-021419-nypnib0h	29	5	-	-	JJ
cord-021419-nypnib0h	29	6	infective	infective	JJ
cord-021419-nypnib0h	29	7	drugs	drug	NNS
cord-021419-nypnib0h	29	8	and	and	CC
cord-021419-nypnib0h	29	9	the	the	DT
cord-021419-nypnib0h	29	10	creation	creation	NN
cord-021419-nypnib0h	29	11	of	of	IN
cord-021419-nypnib0h	29	12	marketable	marketable	JJ
cord-021419-nypnib0h	29	13	products	product	NNS
cord-021419-nypnib0h	29	14	are	be	VBP
cord-021419-nypnib0h	29	15	still	still	RB
cord-021419-nypnib0h	29	16	a	a	DT
cord-021419-nypnib0h	29	17	challenge	challenge	NN
cord-021419-nypnib0h	29	18	.	.	.
cord-021419-nypnib0h	30	1	2	2	LS
cord-021419-nypnib0h	31	1	Since	since	IN
cord-021419-nypnib0h	31	2	the	the	DT
cord-021419-nypnib0h	31	3	development	development	NN
cord-021419-nypnib0h	31	4	of	of	IN
cord-021419-nypnib0h	31	5	medicines	medicine	NNS
cord-021419-nypnib0h	31	6	for	for	IN
cord-021419-nypnib0h	31	7	the	the	DT
cord-021419-nypnib0h	31	8	treatment	treatment	NN
cord-021419-nypnib0h	31	9	of	of	IN
cord-021419-nypnib0h	31	10	chronic	chronic	JJ
cord-021419-nypnib0h	31	11	diseases	disease	NNS
cord-021419-nypnib0h	31	12	is	be	VBZ
cord-021419-nypnib0h	31	13	much	much	RB
cord-021419-nypnib0h	31	14	more	more	RBR
cord-021419-nypnib0h	31	15	profitable	profitable	JJ
cord-021419-nypnib0h	31	16	and	and	CC
cord-021419-nypnib0h	31	17	because	because	IN
cord-021419-nypnib0h	31	18	of	of	IN
cord-021419-nypnib0h	31	19	high	high	JJ
cord-021419-nypnib0h	31	20	requirements	requirement	NNS
cord-021419-nypnib0h	31	21	for	for	IN
cord-021419-nypnib0h	31	22	safety	safety	NN
cord-021419-nypnib0h	31	23	,	,	,
cord-021419-nypnib0h	31	24	large	large	JJ
cord-021419-nypnib0h	31	25	cap	cap	NN
cord-021419-nypnib0h	31	26	pharmaceutical	pharmaceutical	NN
cord-021419-nypnib0h	31	27	companies	company	NNS
cord-021419-nypnib0h	31	28	(	(	-LRB-
cord-021419-nypnib0h	31	29	big	big	JJ
cord-021419-nypnib0h	31	30	pharma	pharma	NNP
cord-021419-nypnib0h	31	31	)	)	-RRB-
cord-021419-nypnib0h	31	32	shut	shut	VBD
cord-021419-nypnib0h	31	33	down	down	RP
cord-021419-nypnib0h	31	34	their	-PRON-	PRP$
cord-021419-nypnib0h	31	35	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	31	36	research	research	NN
cord-021419-nypnib0h	31	37	projects	project	NNS
cord-021419-nypnib0h	31	38	.	.	.
cord-021419-nypnib0h	32	1	Currently	currently	RB
cord-021419-nypnib0h	32	2	,	,	,
cord-021419-nypnib0h	32	3	small	small	JJ
cord-021419-nypnib0h	32	4	-	-	HYPH
cord-021419-nypnib0h	32	5	and	and	CC
cord-021419-nypnib0h	32	6	medium	medium	JJ
cord-021419-nypnib0h	32	7	-	-	HYPH
cord-021419-nypnib0h	32	8	sized	sized	JJ
cord-021419-nypnib0h	32	9	enterprises	enterprise	NNS
cord-021419-nypnib0h	32	10	are	be	VBP
cord-021419-nypnib0h	32	11	developing	develop	VBG
cord-021419-nypnib0h	32	12	a	a	DT
cord-021419-nypnib0h	32	13	majority	majority	NN
cord-021419-nypnib0h	32	14	of	of	IN
cord-021419-nypnib0h	32	15	new	new	JJ
cord-021419-nypnib0h	32	16	drugs	drug	NNS
cord-021419-nypnib0h	32	17	through	through	IN
cord-021419-nypnib0h	32	18	investments	investment	NNS
cord-021419-nypnib0h	32	19	,	,	,
cord-021419-nypnib0h	32	20	venture	venture	NN
cord-021419-nypnib0h	32	21	capital	capital	NN
cord-021419-nypnib0h	32	22	,	,	,
cord-021419-nypnib0h	32	23	etc	etc	FW
cord-021419-nypnib0h	32	24	.	.	.
cord-021419-nypnib0h	33	1	Because	because	IN
cord-021419-nypnib0h	33	2	of	of	IN
cord-021419-nypnib0h	33	3	high	high	JJ
cord-021419-nypnib0h	33	4	demands	demand	NNS
cord-021419-nypnib0h	33	5	for	for	IN
cord-021419-nypnib0h	33	6	new	new	JJ
cord-021419-nypnib0h	33	7	anti	anti	JJ
cord-021419-nypnib0h	33	8	-	-	JJ
cord-021419-nypnib0h	33	9	infective	infective	JJ
cord-021419-nypnib0h	33	10	drugs	drug	NNS
cord-021419-nypnib0h	33	11	and	and	CC
cord-021419-nypnib0h	33	12	extremely	extremely	RB
cord-021419-nypnib0h	33	13	high	high	JJ
cord-021419-nypnib0h	33	14	cost	cost	NN
cord-021419-nypnib0h	33	15	of	of	IN
cord-021419-nypnib0h	33	16	these	these	DT
cord-021419-nypnib0h	33	17	works	work	NNS
cord-021419-nypnib0h	33	18	,	,	,
cord-021419-nypnib0h	33	19	cross	cross	NN
cord-021419-nypnib0h	33	20	-	-	JJ
cord-021419-nypnib0h	33	21	country	country	JJ
cord-021419-nypnib0h	33	22	collaborations	collaboration	NNS
cord-021419-nypnib0h	33	23	are	be	VBP
cord-021419-nypnib0h	33	24	needed	need	VBN
cord-021419-nypnib0h	33	25	for	for	IN
cord-021419-nypnib0h	33	26	research	research	NN
cord-021419-nypnib0h	33	27	in	in	IN
cord-021419-nypnib0h	33	28	this	this	DT
cord-021419-nypnib0h	33	29	field	field	NN
cord-021419-nypnib0h	33	30	.	.	.
cord-021419-nypnib0h	34	1	Only	only	RB
cord-021419-nypnib0h	34	2	a	a	DT
cord-021419-nypnib0h	34	3	few	few	JJ
cord-021419-nypnib0h	34	4	new	new	JJ
cord-021419-nypnib0h	34	5	compounds	compound	NNS
cord-021419-nypnib0h	34	6	were	be	VBD
cord-021419-nypnib0h	34	7	approved	approve	VBN
cord-021419-nypnib0h	34	8	for	for	IN
cord-021419-nypnib0h	34	9	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	34	10	use	use	NN
cord-021419-nypnib0h	34	11	in	in	IN
cord-021419-nypnib0h	34	12	human	human	JJ
cord-021419-nypnib0h	34	13	medicine	medicine	NN
cord-021419-nypnib0h	34	14	or	or	CC
cord-021419-nypnib0h	34	15	have	have	VBP
cord-021419-nypnib0h	34	16	completed	complete	VBN
cord-021419-nypnib0h	34	17	phase	phase	NN
cord-021419-nypnib0h	34	18	-	-	HYPH
cord-021419-nypnib0h	34	19	III	iii	CD
cord-021419-nypnib0h	34	20	clinical	clinical	JJ
cord-021419-nypnib0h	34	21	trials	trial	NNS
cord-021419-nypnib0h	34	22	.	.	.
cord-021419-nypnib0h	35	1	3	3	LS
cord-021419-nypnib0h	36	1	The	the	DT
cord-021419-nypnib0h	36	2	problems	problem	NNS
cord-021419-nypnib0h	36	3	are	be	VBP
cord-021419-nypnib0h	36	4	compounded	compound	VBN
cord-021419-nypnib0h	36	5	by	by	IN
cord-021419-nypnib0h	36	6	the	the	DT
cord-021419-nypnib0h	36	7	fact	fact	NN
cord-021419-nypnib0h	36	8	that	that	IN
cord-021419-nypnib0h	36	9	the	the	DT
cord-021419-nypnib0h	36	10	increasing	increase	VBG
cord-021419-nypnib0h	36	11	percentage	percentage	NN
cord-021419-nypnib0h	36	12	of	of	IN
cord-021419-nypnib0h	36	13	the	the	DT
cord-021419-nypnib0h	36	14	population	population	NN
cord-021419-nypnib0h	36	15	,	,	,
cord-021419-nypnib0h	36	16	particularly	particularly	RB
cord-021419-nypnib0h	36	17	in	in	IN
cord-021419-nypnib0h	36	18	developed	develop	VBN
cord-021419-nypnib0h	36	19	countries	country	NNS
cord-021419-nypnib0h	36	20	and	and	CC
cord-021419-nypnib0h	36	21	Russia	Russia	NNP
cord-021419-nypnib0h	36	22	,	,	,
cord-021419-nypnib0h	36	23	suffer	suffer	VBP
cord-021419-nypnib0h	36	24	from	from	IN
cord-021419-nypnib0h	36	25	infections	infection	NNS
cord-021419-nypnib0h	36	26	that	that	WDT
cord-021419-nypnib0h	36	27	were	be	VBD
cord-021419-nypnib0h	36	28	not	not	RB
cord-021419-nypnib0h	36	29	earlier	early	RBR
cord-021419-nypnib0h	36	30	dangerous	dangerous	JJ
cord-021419-nypnib0h	36	31	,	,	,
cord-021419-nypnib0h	36	32	i.e.	i.e.	FW
cord-021419-nypnib0h	36	33	,	,	,
cord-021419-nypnib0h	36	34	from	from	IN
cord-021419-nypnib0h	36	35	opportunistic	opportunistic	JJ
cord-021419-nypnib0h	36	36	infections	infection	NNS
cord-021419-nypnib0h	36	37	.	.	.
cord-021419-nypnib0h	37	1	This	this	DT
cord-021419-nypnib0h	37	2	is	be	VBZ
cord-021419-nypnib0h	37	3	due	due	JJ
cord-021419-nypnib0h	37	4	to	to	IN
cord-021419-nypnib0h	37	5	a	a	DT
cord-021419-nypnib0h	37	6	significant	significant	JJ
cord-021419-nypnib0h	37	7	decrease	decrease	NN
cord-021419-nypnib0h	37	8	in	in	IN
cord-021419-nypnib0h	37	9	the	the	DT
cord-021419-nypnib0h	37	10	immune	immune	JJ
cord-021419-nypnib0h	37	11	status	status	NN
cord-021419-nypnib0h	37	12	of	of	IN
cord-021419-nypnib0h	37	13	the	the	DT
cord-021419-nypnib0h	37	14	population	population	NN
cord-021419-nypnib0h	37	15	caused	cause	VBN
cord-021419-nypnib0h	37	16	by	by	IN
cord-021419-nypnib0h	37	17	natural	natural	JJ
cord-021419-nypnib0h	37	18	or	or	CC
cord-021419-nypnib0h	37	19	man	man	NN
cord-021419-nypnib0h	37	20	-	-	HYPH
cord-021419-nypnib0h	37	21	made	make	VBN
cord-021419-nypnib0h	37	22	factors	factor	NNS
cord-021419-nypnib0h	37	23	.	.	.
cord-021419-nypnib0h	38	1	The	the	DT
cord-021419-nypnib0h	38	2	translation	translation	NN
cord-021419-nypnib0h	38	3	of	of	IN
cord-021419-nypnib0h	38	4	semi	semi	JJ
cord-021419-nypnib0h	38	5	-	-	JJ
cord-021419-nypnib0h	38	6	synthetic	synthetic	JJ
cord-021419-nypnib0h	38	7	antitumour	antitumour	JJ
cord-021419-nypnib0h	38	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	38	9	(	(	-LRB-
cord-021419-nypnib0h	38	10	e.g.	e.g.	RB
cord-021419-nypnib0h	38	11	,	,	,
cord-021419-nypnib0h	38	12	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	38	13	)	)	-RRB-
cord-021419-nypnib0h	38	14	into	into	IN
cord-021419-nypnib0h	38	15	clinics	clinic	NNS
cord-021419-nypnib0h	38	16	resulted	result	VBN
cord-021419-nypnib0h	38	17	in	in	IN
cord-021419-nypnib0h	38	18	the	the	DT
cord-021419-nypnib0h	38	19	development	development	NN
cord-021419-nypnib0h	38	20	of	of	IN
cord-021419-nypnib0h	38	21	gold	gold	JJ
cord-021419-nypnib0h	38	22	standard	standard	JJ
cord-021419-nypnib0h	38	23	chemotherapeutic	chemotherapeutic	JJ
cord-021419-nypnib0h	38	24	agents	agent	NNS
cord-021419-nypnib0h	38	25	.	.	.
cord-021419-nypnib0h	39	1	Many	many	JJ
cord-021419-nypnib0h	39	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	39	3	have	have	VBP
cord-021419-nypnib0h	39	4	made	make	VBN
cord-021419-nypnib0h	39	5	a	a	DT
cord-021419-nypnib0h	39	6	great	great	JJ
cord-021419-nypnib0h	39	7	contribution	contribution	NN
cord-021419-nypnib0h	39	8	to	to	IN
cord-021419-nypnib0h	39	9	understanding	understanding	NN
cord-021419-nypnib0h	39	10	of	of	IN
cord-021419-nypnib0h	39	11	mechanisms	mechanism	NNS
cord-021419-nypnib0h	39	12	of	of	IN
cord-021419-nypnib0h	39	13	development	development	NN
cord-021419-nypnib0h	39	14	of	of	IN
cord-021419-nypnib0h	39	15	resistance	resistance	NN
cord-021419-nypnib0h	39	16	in	in	IN
cord-021419-nypnib0h	39	17	bacterial	bacterial	JJ
cord-021419-nypnib0h	39	18	and	and	CC
cord-021419-nypnib0h	39	19	tumour	tumour	NN
cord-021419-nypnib0h	39	20	cells	cell	NNS
cord-021419-nypnib0h	39	21	.	.	.
cord-021419-nypnib0h	40	1	Due	due	IN
cord-021419-nypnib0h	40	2	to	to	IN
cord-021419-nypnib0h	40	3	high	high	JJ
cord-021419-nypnib0h	40	4	innate	innate	NN
cord-021419-nypnib0h	40	5	or	or	CC
cord-021419-nypnib0h	40	6	acquired	acquire	VBN
cord-021419-nypnib0h	40	7	drug	drug	NN
cord-021419-nypnib0h	40	8	resistance	resistance	NN
cord-021419-nypnib0h	40	9	of	of	IN
cord-021419-nypnib0h	40	10	cancer	cancer	NN
cord-021419-nypnib0h	40	11	cells	cell	NNS
cord-021419-nypnib0h	40	12	,	,	,
cord-021419-nypnib0h	40	13	chemotherapy	chemotherapy	NN
cord-021419-nypnib0h	40	14	of	of	IN
cord-021419-nypnib0h	40	15	malignant	malignant	JJ
cord-021419-nypnib0h	40	16	tumours	tumour	NNS
cord-021419-nypnib0h	40	17	is	be	VBZ
cord-021419-nypnib0h	40	18	often	often	RB
cord-021419-nypnib0h	40	19	ineffective	ineffective	JJ
cord-021419-nypnib0h	40	20	.	.	.
cord-021419-nypnib0h	41	1	The	the	DT
cord-021419-nypnib0h	41	2	international	international	JJ
cord-021419-nypnib0h	41	3	research	research	NN
cord-021419-nypnib0h	41	4	community	community	NN
cord-021419-nypnib0h	41	5	has	have	VBZ
cord-021419-nypnib0h	41	6	focused	focus	VBN
cord-021419-nypnib0h	41	7	its	-PRON-	PRP$
cord-021419-nypnib0h	41	8	attention	attention	NN
cord-021419-nypnib0h	41	9	on	on	IN
cord-021419-nypnib0h	41	10	the	the	DT
cord-021419-nypnib0h	41	11	search	search	NN
cord-021419-nypnib0h	41	12	for	for	IN
cord-021419-nypnib0h	41	13	new	new	JJ
cord-021419-nypnib0h	41	14	,	,	,
cord-021419-nypnib0h	41	15	more	more	RBR
cord-021419-nypnib0h	41	16	effective	effective	JJ
cord-021419-nypnib0h	41	17	and	and	CC
cord-021419-nypnib0h	41	18	less	less	RBR
cord-021419-nypnib0h	41	19	toxic	toxic	JJ
cord-021419-nypnib0h	41	20	antitumour	antitumour	JJ
cord-021419-nypnib0h	41	21	agents	agent	NNS
cord-021419-nypnib0h	41	22	.	.	.
cord-021419-nypnib0h	42	1	One	one	CD
cord-021419-nypnib0h	42	2	of	of	IN
cord-021419-nypnib0h	42	3	the	the	DT
cord-021419-nypnib0h	42	4	most	most	RBS
cord-021419-nypnib0h	42	5	rational	rational	JJ
cord-021419-nypnib0h	42	6	approaches	approach	NNS
cord-021419-nypnib0h	42	7	to	to	IN
cord-021419-nypnib0h	42	8	the	the	DT
cord-021419-nypnib0h	42	9	targeted	target	VBN
cord-021419-nypnib0h	42	10	therapy	therapy	NN
cord-021419-nypnib0h	42	11	is	be	VBZ
cord-021419-nypnib0h	42	12	based	base	VBN
cord-021419-nypnib0h	42	13	on	on	IN
cord-021419-nypnib0h	42	14	the	the	DT
cord-021419-nypnib0h	42	15	search	search	NN
cord-021419-nypnib0h	42	16	for	for	IN
cord-021419-nypnib0h	42	17	inhibitors	inhibitor	NNS
cord-021419-nypnib0h	42	18	of	of	IN
cord-021419-nypnib0h	42	19	important	important	JJ
cord-021419-nypnib0h	42	20	tumour	tumour	NN
cord-021419-nypnib0h	42	21	cell	cell	NN
cord-021419-nypnib0h	42	22	targets	target	NNS
cord-021419-nypnib0h	42	23	among	among	IN
cord-021419-nypnib0h	42	24	natural	natural	JJ
cord-021419-nypnib0h	42	25	products	product	NNS
cord-021419-nypnib0h	42	26	,	,	,
cord-021419-nypnib0h	42	27	primarily	primarily	RB
cord-021419-nypnib0h	42	28	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	42	29	.	.	.
cord-021419-nypnib0h	43	1	4	4	LS
cord-021419-nypnib0h	44	1	Even	even	RB
cord-021419-nypnib0h	44	2	the	the	DT
cord-021419-nypnib0h	44	3	repurposing	repurposing	NN
cord-021419-nypnib0h	44	4	of	of	IN
cord-021419-nypnib0h	44	5	known	know	VBN
cord-021419-nypnib0h	44	6	antitumour	antitumour	NNP
cord-021419-nypnib0h	44	7	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	44	8	is	be	VBZ
cord-021419-nypnib0h	44	9	considered	consider	VBN
cord-021419-nypnib0h	44	10	in	in	IN
cord-021419-nypnib0h	44	11	order	order	NN
cord-021419-nypnib0h	44	12	to	to	TO
cord-021419-nypnib0h	44	13	address	address	VB
cord-021419-nypnib0h	44	14	the	the	DT
cord-021419-nypnib0h	44	15	problem	problem	NN
cord-021419-nypnib0h	44	16	of	of	IN
cord-021419-nypnib0h	44	17	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	44	18	resistance	resistance	NN
cord-021419-nypnib0h	44	19	of	of	IN
cord-021419-nypnib0h	44	20	antiinfective	antiinfective	JJ
cord-021419-nypnib0h	44	21	agents	agent	NNS
cord-021419-nypnib0h	44	22	.	.	.
cord-021419-nypnib0h	45	1	5	5	LS
cord-021419-nypnib0h	45	2	Researchers	researcher	NNS
cord-021419-nypnib0h	45	3	of	of	IN
cord-021419-nypnib0h	45	4	the	the	DT
cord-021419-nypnib0h	45	5	Gause	Gause	NNP
cord-021419-nypnib0h	45	6	Institute	Institute	NNP
cord-021419-nypnib0h	45	7	of	of	IN
cord-021419-nypnib0h	45	8	New	New	NNP
cord-021419-nypnib0h	45	9	Antibiotics	Antibiotics	NNP
cord-021419-nypnib0h	45	10	(	(	-LRB-
cord-021419-nypnib0h	45	11	GINA	GINA	NNP
cord-021419-nypnib0h	45	12	)	)	-RRB-
cord-021419-nypnib0h	45	13	headed	head	VBN
cord-021419-nypnib0h	45	14	by	by	IN
cord-021419-nypnib0h	45	15	Academician	Academician	NNP
cord-021419-nypnib0h	45	16	of	of	IN
cord-021419-nypnib0h	45	17	the	the	DT
cord-021419-nypnib0h	45	18	USSR	USSR	NNP
cord-021419-nypnib0h	45	19	Academy	Academy	NNP
cord-021419-nypnib0h	45	20	of	of	IN
cord-021419-nypnib0h	45	21	Medical	Medical	NNP
cord-021419-nypnib0h	45	22	Sciences	Sciences	NNPS
cord-021419-nypnib0h	45	23	G.F.Gause	G.F.Gause	NNP
cord-021419-nypnib0h	45	24	in	in	IN
cord-021419-nypnib0h	45	25	the	the	DT
cord-021419-nypnib0h	45	26	1960	1960	CD
cord-021419-nypnib0h	45	27	±	±	NNP
cord-021419-nypnib0h	45	28	1990s	1990	NNS
cord-021419-nypnib0h	45	29	made	make	VBD
cord-021419-nypnib0h	45	30	considerable	considerable	JJ
cord-021419-nypnib0h	45	31	contribution	contribution	NN
cord-021419-nypnib0h	45	32	to	to	IN
cord-021419-nypnib0h	45	33	the	the	DT
cord-021419-nypnib0h	45	34	discovery	discovery	NN
cord-021419-nypnib0h	45	35	of	of	IN
cord-021419-nypnib0h	45	36	a	a	DT
cord-021419-nypnib0h	45	37	series	series	NN
cord-021419-nypnib0h	45	38	of	of	IN
cord-021419-nypnib0h	45	39	original	original	JJ
cord-021419-nypnib0h	45	40	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	45	41	and	and	CC
cord-021419-nypnib0h	45	42	antitumour	antitumour	JJ
cord-021419-nypnib0h	45	43	agents	agent	NNS
cord-021419-nypnib0h	45	44	(	(	-LRB-
cord-021419-nypnib0h	45	45	a	a	DT
cord-021419-nypnib0h	45	46	total	total	NN
cord-021419-nypnib0h	45	47	of	of	IN
cord-021419-nypnib0h	45	48	15	15	CD
cord-021419-nypnib0h	45	49	compounds	compound	NNS
cord-021419-nypnib0h	45	50	)	)	-RRB-
cord-021419-nypnib0h	45	51	,	,	,
cord-021419-nypnib0h	45	52	their	-PRON-	PRP$
cord-021419-nypnib0h	45	53	characterization	characterization	NN
cord-021419-nypnib0h	45	54	and	and	CC
cord-021419-nypnib0h	45	55	introduction	introduction	NN
cord-021419-nypnib0h	45	56	to	to	IN
cord-021419-nypnib0h	45	57	medical	medical	JJ
cord-021419-nypnib0h	45	58	practice	practice	NN
cord-021419-nypnib0h	45	59	.	.	.
cord-021419-nypnib0h	46	1	Major	major	JJ
cord-021419-nypnib0h	46	2	achievements	achievement	NNS
cord-021419-nypnib0h	46	3	of	of	IN
cord-021419-nypnib0h	46	4	the	the	DT
cord-021419-nypnib0h	46	5	Institute	Institute	NNP
cord-021419-nypnib0h	46	6	during	during	IN
cord-021419-nypnib0h	46	7	this	this	DT
cord-021419-nypnib0h	46	8	period	period	NN
cord-021419-nypnib0h	46	9	are	be	VBP
cord-021419-nypnib0h	46	10	considered	consider	VBN
cord-021419-nypnib0h	46	11	in	in	IN
cord-021419-nypnib0h	46	12	the	the	DT
cord-021419-nypnib0h	46	13	review	review	NN
cord-021419-nypnib0h	46	14	.	.	.
cord-021419-nypnib0h	47	1	6	6	CD
cord-021419-nypnib0h	47	2	Antibiotics	antibiotic	NNS
cord-021419-nypnib0h	47	3	comprise	comprise	VBP
cord-021419-nypnib0h	47	4	an	an	DT
cord-021419-nypnib0h	47	5	important	important	JJ
cord-021419-nypnib0h	47	6	class	class	NN
cord-021419-nypnib0h	47	7	of	of	IN
cord-021419-nypnib0h	47	8	natural	natural	JJ
cord-021419-nypnib0h	47	9	products	product	NNS
cord-021419-nypnib0h	47	10	with	with	IN
cord-021419-nypnib0h	47	11	unique	unique	JJ
cord-021419-nypnib0h	47	12	structural	structural	JJ
cord-021419-nypnib0h	47	13	diversity	diversity	NN
cord-021419-nypnib0h	47	14	.	.	.
cord-021419-nypnib0h	48	1	Chemical	chemical	NN
cord-021419-nypnib0h	48	2	transformations	transformation	NNS
cord-021419-nypnib0h	48	3	of	of	IN
cord-021419-nypnib0h	48	4	natural	natural	JJ
cord-021419-nypnib0h	48	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	48	6	imply	imply	VBP
cord-021419-nypnib0h	48	7	a	a	DT
cord-021419-nypnib0h	48	8	change	change	NN
cord-021419-nypnib0h	48	9	of	of	IN
cord-021419-nypnib0h	48	10	particular	particular	JJ
cord-021419-nypnib0h	48	11	functional	functional	JJ
cord-021419-nypnib0h	48	12	groups	group	NNS
cord-021419-nypnib0h	48	13	of	of	IN
cord-021419-nypnib0h	48	14	the	the	DT
cord-021419-nypnib0h	48	15	starting	starting	NN
cord-021419-nypnib0h	48	16	molecules	molecule	NNS
cord-021419-nypnib0h	48	17	with	with	IN
cord-021419-nypnib0h	48	18	preservation	preservation	NN
cord-021419-nypnib0h	48	19	of	of	IN
cord-021419-nypnib0h	48	20	structural	structural	JJ
cord-021419-nypnib0h	48	21	elements	element	NNS
cord-021419-nypnib0h	48	22	responsible	responsible	JJ
cord-021419-nypnib0h	48	23	for	for	IN
cord-021419-nypnib0h	48	24	biological	biological	JJ
cord-021419-nypnib0h	48	25	activity	activity	NN
cord-021419-nypnib0h	48	26	.	.	.
cord-021419-nypnib0h	49	1	The	the	DT
cord-021419-nypnib0h	49	2	structure	structure	NN
cord-021419-nypnib0h	49	3	determines	determine	VBZ
cord-021419-nypnib0h	49	4	the	the	DT
cord-021419-nypnib0h	49	5	possibility	possibility	NN
cord-021419-nypnib0h	49	6	of	of	IN
cord-021419-nypnib0h	49	7	chemical	chemical	JJ
cord-021419-nypnib0h	49	8	transformation	transformation	NN
cord-021419-nypnib0h	49	9	of	of	IN
cord-021419-nypnib0h	49	10	the	the	DT
cord-021419-nypnib0h	49	11	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	49	12	and	and	CC
cord-021419-nypnib0h	49	13	reaction	reaction	NN
cord-021419-nypnib0h	49	14	conditions	condition	NNS
cord-021419-nypnib0h	49	15	.	.	.
cord-021419-nypnib0h	50	1	For	for	IN
cord-021419-nypnib0h	50	2	example	example	NN
cord-021419-nypnib0h	50	3	,	,	,
cord-021419-nypnib0h	50	4	many	many	JJ
cord-021419-nypnib0h	50	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	50	6	contain	contain	VBP
cord-021419-nypnib0h	50	7	nitrogenous	nitrogenous	JJ
cord-021419-nypnib0h	50	8	and(or	and(or	NNP
cord-021419-nypnib0h	50	9	)	)	-RRB-
cord-021419-nypnib0h	50	10	nitrogen	nitrogen	NN
cord-021419-nypnib0h	50	11	-	-	HYPH
cord-021419-nypnib0h	50	12	free	free	JJ
cord-021419-nypnib0h	50	13	sugars	sugar	NNS
cord-021419-nypnib0h	50	14	,	,	,
cord-021419-nypnib0h	50	15	which	which	WDT
cord-021419-nypnib0h	50	16	are	be	VBP
cord-021419-nypnib0h	50	17	easily	easily	RB
cord-021419-nypnib0h	50	18	eliminated	eliminate	VBN
cord-021419-nypnib0h	50	19	in	in	IN
cord-021419-nypnib0h	50	20	acidic	acidic	JJ
cord-021419-nypnib0h	50	21	or	or	CC
cord-021419-nypnib0h	50	22	alkaline	alkaline	JJ
cord-021419-nypnib0h	50	23	media	medium	NNS
cord-021419-nypnib0h	50	24	.	.	.
cord-021419-nypnib0h	51	1	Many	many	JJ
cord-021419-nypnib0h	51	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	51	3	are	be	VBP
cord-021419-nypnib0h	51	4	sensitive	sensitive	JJ
cord-021419-nypnib0h	51	5	to	to	IN
cord-021419-nypnib0h	51	6	oxidants	oxidant	NNS
cord-021419-nypnib0h	51	7	,	,	,
cord-021419-nypnib0h	51	8	are	be	VBP
cord-021419-nypnib0h	51	9	poorly	poorly	RB
cord-021419-nypnib0h	51	10	soluble	soluble	JJ
cord-021419-nypnib0h	51	11	in	in	IN
cord-021419-nypnib0h	51	12	organic	organic	JJ
cord-021419-nypnib0h	51	13	media	medium	NNS
cord-021419-nypnib0h	51	14	or	or	CC
cord-021419-nypnib0h	51	15	,	,	,
cord-021419-nypnib0h	51	16	on	on	IN
cord-021419-nypnib0h	51	17	the	the	DT
cord-021419-nypnib0h	51	18	contrary	contrary	NN
cord-021419-nypnib0h	51	19	,	,	,
cord-021419-nypnib0h	51	20	in	in	IN
cord-021419-nypnib0h	51	21	aqueous	aqueous	JJ
cord-021419-nypnib0h	51	22	solutions	solution	NNS
cord-021419-nypnib0h	51	23	,	,	,
cord-021419-nypnib0h	51	24	etc	etc	FW
cord-021419-nypnib0h	51	25	.	.	.
cord-021419-nypnib0h	52	1	On	on	IN
cord-021419-nypnib0h	52	2	the	the	DT
cord-021419-nypnib0h	52	3	other	other	JJ
cord-021419-nypnib0h	52	4	hand	hand	NN
cord-021419-nypnib0h	52	5	,	,	,
cord-021419-nypnib0h	52	6	in	in	IN
cord-021419-nypnib0h	52	7	the	the	DT
cord-021419-nypnib0h	52	8	case	case	NN
cord-021419-nypnib0h	52	9	of	of	IN
cord-021419-nypnib0h	52	10	similar	similar	JJ
cord-021419-nypnib0h	52	11	structures	structure	NNS
cord-021419-nypnib0h	52	12	of	of	IN
cord-021419-nypnib0h	52	13	certain	certain	JJ
cord-021419-nypnib0h	52	14	moieties	moiety	NNS
cord-021419-nypnib0h	52	15	[	[	-LRB-
cord-021419-nypnib0h	52	16	e.g.	e.g.	RB
cord-021419-nypnib0h	52	17	,	,	,
cord-021419-nypnib0h	52	18	the	the	DT
cord-021419-nypnib0h	52	19	presence	presence	NN
cord-021419-nypnib0h	52	20	of	of	IN
cord-021419-nypnib0h	52	21	NH	NH	NNP
cord-021419-nypnib0h	52	22	2	2	CD
cord-021419-nypnib0h	52	23	,	,	,
cord-021419-nypnib0h	52	24	CO	CO	NNP
cord-021419-nypnib0h	52	25	2	2	CD
cord-021419-nypnib0h	52	26	H	H	NNP
cord-021419-nypnib0h	52	27	,	,	,
cord-021419-nypnib0h	52	28	OH	oh	UH
cord-021419-nypnib0h	52	29	,	,	,
cord-021419-nypnib0h	52	30	C(O	C(O	NNP
cord-021419-nypnib0h	52	31	)	)	-RRB-
cord-021419-nypnib0h	52	32	,	,	,
cord-021419-nypnib0h	52	33	etc	etc	FW
cord-021419-nypnib0h	52	34	.	.	.
cord-021419-nypnib0h	52	35	groups	group	NNS
cord-021419-nypnib0h	52	36	)	)	-RRB-
cord-021419-nypnib0h	52	37	]	]	-RRB-
cord-021419-nypnib0h	52	38	,	,	,
cord-021419-nypnib0h	52	39	methods	method	NNS
cord-021419-nypnib0h	52	40	developed	develop	VBN
cord-021419-nypnib0h	52	41	for	for	IN
cord-021419-nypnib0h	52	42	one	one	CD
cord-021419-nypnib0h	52	43	class	class	NN
cord-021419-nypnib0h	52	44	of	of	IN
cord-021419-nypnib0h	52	45	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	52	46	can	can	MD
cord-021419-nypnib0h	52	47	be	be	VB
cord-021419-nypnib0h	52	48	applied	apply	VBN
cord-021419-nypnib0h	52	49	to	to	IN
cord-021419-nypnib0h	52	50	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	52	51	of	of	IN
cord-021419-nypnib0h	52	52	another	another	DT
cord-021419-nypnib0h	52	53	class	class	NN
cord-021419-nypnib0h	52	54	.	.	.
cord-021419-nypnib0h	53	1	The	the	DT
cord-021419-nypnib0h	53	2	goal	goal	NN
cord-021419-nypnib0h	53	3	of	of	IN
cord-021419-nypnib0h	53	4	synthetic	synthetic	JJ
cord-021419-nypnib0h	53	5	chemists	chemist	NNS
cord-021419-nypnib0h	53	6	is	be	VBZ
cord-021419-nypnib0h	53	7	to	to	TO
cord-021419-nypnib0h	53	8	transform	transform	VB
cord-021419-nypnib0h	53	9	natural	natural	JJ
cord-021419-nypnib0h	53	10	products	product	NNS
cord-021419-nypnib0h	53	11	with	with	IN
cord-021419-nypnib0h	53	12	preservation	preservation	NN
cord-021419-nypnib0h	53	13	of	of	IN
cord-021419-nypnib0h	53	14	the	the	DT
cord-021419-nypnib0h	53	15	sites	site	NNS
cord-021419-nypnib0h	53	16	responsible	responsible	JJ
cord-021419-nypnib0h	53	17	for	for	IN
cord-021419-nypnib0h	53	18	biological	biological	JJ
cord-021419-nypnib0h	53	19	activity	activity	NN
cord-021419-nypnib0h	53	20	.	.	.
cord-021419-nypnib0h	54	1	Besides	besides	RB
cord-021419-nypnib0h	54	2	,	,	,
cord-021419-nypnib0h	54	3	targeted	target	VBN
cord-021419-nypnib0h	54	4	modification	modification	NN
cord-021419-nypnib0h	54	5	can	can	MD
cord-021419-nypnib0h	54	6	be	be	VB
cord-021419-nypnib0h	54	7	performed	perform	VBN
cord-021419-nypnib0h	54	8	to	to	TO
cord-021419-nypnib0h	54	9	gain	gain	VB
cord-021419-nypnib0h	54	10	better	well	JJR
cord-021419-nypnib0h	54	11	understanding	understanding	NN
cord-021419-nypnib0h	54	12	of	of	IN
cord-021419-nypnib0h	54	13	the	the	DT
cord-021419-nypnib0h	54	14	mechanisms	mechanism	NNS
cord-021419-nypnib0h	54	15	of	of	IN
cord-021419-nypnib0h	54	16	action	action	NN
cord-021419-nypnib0h	54	17	,	,	,
cord-021419-nypnib0h	54	18	in	in	IN
cord-021419-nypnib0h	54	19	particular	particular	JJ
cord-021419-nypnib0h	54	20	in	in	IN
cord-021419-nypnib0h	54	21	order	order	NN
cord-021419-nypnib0h	54	22	to	to	TO
cord-021419-nypnib0h	54	23	investigate	investigate	VB
cord-021419-nypnib0h	54	24	the	the	DT
cord-021419-nypnib0h	54	25	interaction	interaction	NN
cord-021419-nypnib0h	54	26	between	between	IN
cord-021419-nypnib0h	54	27	the	the	DT
cord-021419-nypnib0h	54	28	antibiotic	antibiotic	NN
cord-021419-nypnib0h	54	29	and	and	CC
cord-021419-nypnib0h	54	30	the	the	DT
cord-021419-nypnib0h	54	31	target	target	NN
cord-021419-nypnib0h	54	32	.	.	.
cord-021419-nypnib0h	55	1	In	in	IN
cord-021419-nypnib0h	55	2	this	this	DT
cord-021419-nypnib0h	55	3	review	review	NN
cord-021419-nypnib0h	55	4	,	,	,
cord-021419-nypnib0h	55	5	the	the	DT
cord-021419-nypnib0h	55	6	following	follow	VBG
cord-021419-nypnib0h	55	7	classes	class	NNS
cord-021419-nypnib0h	55	8	of	of	IN
cord-021419-nypnib0h	55	9	compounds	compound	NNS
cord-021419-nypnib0h	55	10	are	be	VBP
cord-021419-nypnib0h	55	11	considered	consider	VBN
cord-021419-nypnib0h	55	12	as	as	IN
cord-021419-nypnib0h	55	13	scaffolds	scaffold	NNS
cord-021419-nypnib0h	55	14	for	for	IN
cord-021419-nypnib0h	55	15	the	the	DT
cord-021419-nypnib0h	55	16	synthesis	synthesis	NN
cord-021419-nypnib0h	55	17	of	of	IN
cord-021419-nypnib0h	55	18	new	new	JJ
cord-021419-nypnib0h	55	19	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	55	20	:	:	:
cord-021419-nypnib0h	56	1	polycyclic	polycyclic	NNP
cord-021419-nypnib0h	56	2	glycopeptides	glycopeptides	NNP
cord-021419-nypnib0h	56	3	of	of	IN
cord-021419-nypnib0h	56	4	the	the	DT
cord-021419-nypnib0h	56	5	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	56	6	±	±	NNP
cord-021419-nypnib0h	56	7	teicoplanin	teicoplanin	NN
cord-021419-nypnib0h	56	8	group	group	NN
cord-021419-nypnib0h	56	9	,	,	,
cord-021419-nypnib0h	56	10	classical	classical	JJ
cord-021419-nypnib0h	56	11	macrolides	macrolide	NNS
cord-021419-nypnib0h	56	12	,	,	,
cord-021419-nypnib0h	56	13	macrolides	macrolide	NNS
cord-021419-nypnib0h	56	14	of	of	IN
cord-021419-nypnib0h	56	15	the	the	DT
cord-021419-nypnib0h	56	16	amphotericin	amphotericin	NNS
cord-021419-nypnib0h	56	17	B	B	NNP
cord-021419-nypnib0h	56	18	±	±	NNP
cord-021419-nypnib0h	56	19	oligomycin	oligomycin	NN
cord-021419-nypnib0h	56	20	group	group	NN
cord-021419-nypnib0h	56	21	,	,	,
cord-021419-nypnib0h	56	22	anthracyclines	anthracyclines	NNP
cord-021419-nypnib0h	56	23	,	,	,
cord-021419-nypnib0h	56	24	aureolic	aureolic	NNP
cord-021419-nypnib0h	56	25	acid	acid	JJ
cord-021419-nypnib0h	56	26	derivatives	derivative	NNS
cord-021419-nypnib0h	56	27	,	,	,
cord-021419-nypnib0h	56	28	heliomycin	heliomycin	NNS
cord-021419-nypnib0h	56	29	,	,	,
cord-021419-nypnib0h	56	30	synthetic	synthetic	JJ
cord-021419-nypnib0h	56	31	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	56	32	and	and	CC
cord-021419-nypnib0h	56	33	some	some	DT
cord-021419-nypnib0h	56	34	other	other	JJ
cord-021419-nypnib0h	56	35	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	56	36	.	.	.
cord-021419-nypnib0h	57	1	Such	such	JJ
cord-021419-nypnib0h	57	2	representatives	representative	NNS
cord-021419-nypnib0h	57	3	as	as	IN
cord-021419-nypnib0h	57	4	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	57	5	,	,	,
cord-021419-nypnib0h	57	6	carminomycin	carminomycin	NNS
cord-021419-nypnib0h	57	7	,	,	,
cord-021419-nypnib0h	57	8	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	57	9	A	A	NNP
cord-021419-nypnib0h	57	10	,	,	,
cord-021419-nypnib0h	57	11	oligomycin	oligomycin	VBZ
cord-021419-nypnib0h	57	12	A	a	NN
cord-021419-nypnib0h	57	13	and	and	CC
cord-021419-nypnib0h	57	14	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	57	15	6	6	CD
cord-021419-nypnib0h	57	16	.	.	.
cord-021419-nypnib0h	58	1	Olivomycin	Olivomycin	NNP
cord-021419-nypnib0h	58	2	A	A	NNP
cord-021419-nypnib0h	58	3	364	364	CD
cord-021419-nypnib0h	58	4	6.1	6.1	CD
cord-021419-nypnib0h	58	5	.	.	.
cord-021419-nypnib0h	59	1	Modification	modification	NN
cord-021419-nypnib0h	59	2	of	of	IN
cord-021419-nypnib0h	59	3	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	59	4	A	a	NN
cord-021419-nypnib0h	59	5	at	at	IN
cord-021419-nypnib0h	59	6	the	the	DT
cord-021419-nypnib0h	59	7	aromatic	aromatic	JJ
cord-021419-nypnib0h	59	8	ring	ring	NN
cord-021419-nypnib0h	59	9	of	of	IN
cord-021419-nypnib0h	59	10	the	the	DT
cord-021419-nypnib0h	59	11	aglycone	aglycone	NN
cord-021419-nypnib0h	59	12	364	364	CD
cord-021419-nypnib0h	59	13	6.2	6.2	CD
cord-021419-nypnib0h	59	14	.	.	.
cord-021419-nypnib0h	60	1	Modification	modification	NN
cord-021419-nypnib0h	60	2	of	of	IN
cord-021419-nypnib0h	60	3	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	60	4	A	a	NN
cord-021419-nypnib0h	60	5	at	at	IN
cord-021419-nypnib0h	60	6	the	the	DT
cord-021419-nypnib0h	60	7	side	side	NN
cord-021419-nypnib0h	60	8	-	-	HYPH
cord-021419-nypnib0h	60	9	chain	chain	NN
cord-021419-nypnib0h	60	10	2	2	CD
cord-021419-nypnib0h	60	11	H	h	NN
cord-021419-nypnib0h	60	12	-keto	-keto	NN
cord-021419-nypnib0h	60	13	group	group	NN
cord-021419-nypnib0h	60	14	of	of	IN
cord-021419-nypnib0h	60	15	the	the	DT
cord-021419-nypnib0h	60	16	aglycone	aglycone	NNP
cord-021419-nypnib0h	60	17	366	366	CD
cord-021419-nypnib0h	60	18	6.3	6.3	CD
cord-021419-nypnib0h	60	19	.	.	.
cord-021419-nypnib0h	61	1	Modification	modification	NN
cord-021419-nypnib0h	61	2	of	of	IN
cord-021419-nypnib0h	61	3	the	the	DT
cord-021419-nypnib0h	61	4	side	side	NN
cord-021419-nypnib0h	61	5	chain	chain	NN
cord-021419-nypnib0h	61	6	at	at	IN
cord-021419-nypnib0h	61	7	the	the	DT
cord-021419-nypnib0h	61	8	C(2	C(2	NNP
cord-021419-nypnib0h	61	9	H	H	NNP
cord-021419-nypnib0h	61	10	)	)	-RRB-
cord-021419-nypnib0h	61	11	7C	7C	NNP
cord-021419-nypnib0h	61	12	(	(	-LRB-
cord-021419-nypnib0h	61	13	3	3	CD
cord-021419-nypnib0h	61	14	H	h	NN
cord-021419-nypnib0h	61	15	 	 	_SP
cord-021419-nypnib0h	62	1	The	the	DT
cord-021419-nypnib0h	62	2	discovery	discovery	NN
cord-021419-nypnib0h	62	3	of	of	IN
cord-021419-nypnib0h	62	4	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	62	5	(	(	-LRB-
cord-021419-nypnib0h	62	6	1	1	CD
cord-021419-nypnib0h	62	7	)	)	-RRB-
cord-021419-nypnib0h	62	8	and	and	CC
cord-021419-nypnib0h	62	9	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	62	10	(	(	-LRB-
cord-021419-nypnib0h	62	11	2	2	CD
cord-021419-nypnib0h	62	12	)	)	-RRB-
cord-021419-nypnib0h	63	1	(	(	-LRB-
cord-021419-nypnib0h	63	2	Fig	Fig	NNP
cord-021419-nypnib0h	63	3	.	.	NNP
cord-021419-nypnib0h	63	4	1	1	CD
cord-021419-nypnib0h	63	5	)	)	-RRB-
cord-021419-nypnib0h	63	6	has	have	VBZ
cord-021419-nypnib0h	63	7	given	give	VBN
cord-021419-nypnib0h	63	8	impetus	impetus	NN
cord-021419-nypnib0h	63	9	to	to	TO
cord-021419-nypnib0h	63	10	research	research	VB
cord-021419-nypnib0h	63	11	on	on	IN
cord-021419-nypnib0h	63	12	polycyclic	polycyclic	JJ
cord-021419-nypnib0h	63	13	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	63	14	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	63	15	.	.	.
cord-021419-nypnib0h	64	1	7	7	CD
cord-021419-nypnib0h	64	2	Natural	natural	JJ
cord-021419-nypnib0h	64	3	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	64	4	1	1	CD
cord-021419-nypnib0h	64	5	and	and	CC
cord-021419-nypnib0h	64	6	2	2	CD
cord-021419-nypnib0h	64	7	are	be	VBP
cord-021419-nypnib0h	64	8	still	still	RB
cord-021419-nypnib0h	64	9	used	use	VBN
cord-021419-nypnib0h	64	10	in	in	IN
cord-021419-nypnib0h	64	11	medical	medical	JJ
cord-021419-nypnib0h	64	12	practice	practice	NN
cord-021419-nypnib0h	64	13	and	and	CC
cord-021419-nypnib0h	64	14	are	be	VBP
cord-021419-nypnib0h	64	15	considered	consider	VBN
cord-021419-nypnib0h	64	16	as	as	IN
cord-021419-nypnib0h	64	17	reserve	reserve	NN
cord-021419-nypnib0h	64	18	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	64	19	.	.	.
cord-021419-nypnib0h	65	1	They	-PRON-	PRP
cord-021419-nypnib0h	65	2	are	be	VBP
cord-021419-nypnib0h	65	3	commonly	commonly	RB
cord-021419-nypnib0h	65	4	applied	apply	VBN
cord-021419-nypnib0h	65	5	for	for	IN
cord-021419-nypnib0h	65	6	the	the	DT
cord-021419-nypnib0h	65	7	treatment	treatment	NN
cord-021419-nypnib0h	65	8	of	of	IN
cord-021419-nypnib0h	65	9	infections	infection	NNS
cord-021419-nypnib0h	65	10	caused	cause	VBN
cord-021419-nypnib0h	65	11	by	by	IN
cord-021419-nypnib0h	65	12	Gram	gram	NN
cord-021419-nypnib0h	65	13	-	-	HYPH
cord-021419-nypnib0h	65	14	positive	positive	JJ
cord-021419-nypnib0h	65	15	cocci	coccus	NNS
cord-021419-nypnib0h	65	16	,	,	,
cord-021419-nypnib0h	65	17	particularly	particularly	RB
cord-021419-nypnib0h	65	18	,	,	,
cord-021419-nypnib0h	65	19	methicillinresistant	methicillinresistant	JJ
cord-021419-nypnib0h	65	20	Staphylococcus	Staphylococcus	NNP
cord-021419-nypnib0h	65	21	aureus	aureus	NN
cord-021419-nypnib0h	65	22	(	(	-LRB-
cord-021419-nypnib0h	65	23	MRSA	MRSA	NNP
cord-021419-nypnib0h	65	24	)	)	-RRB-
cord-021419-nypnib0h	65	25	strains	strain	NNS
cord-021419-nypnib0h	65	26	.	.	.
cord-021419-nypnib0h	66	1	Glycopeptide	Glycopeptide	NNP
cord-021419-nypnib0h	66	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	66	3	bind	bind	VBP
cord-021419-nypnib0h	66	4	with	with	IN
cord-021419-nypnib0h	66	5	high	high	JJ
cord-021419-nypnib0h	66	6	affinity	affinity	NN
cord-021419-nypnib0h	66	7	to	to	IN
cord-021419-nypnib0h	66	8	the	the	DT
cord-021419-nypnib0h	66	9	terminal	terminal	JJ
cord-021419-nypnib0h	66	10	D	D	NNP
cord-021419-nypnib0h	66	11	-	-	HYPH
cord-021419-nypnib0h	66	12	Ala	Ala	NNP
cord-021419-nypnib0h	66	13	-	-	HYPH
cord-021419-nypnib0h	66	14	D	D	NNP
cord-021419-nypnib0h	66	15	-	-	HYPH
cord-021419-nypnib0h	66	16	Ala	Ala	NNP
cord-021419-nypnib0h	66	17	group	group	NN
cord-021419-nypnib0h	66	18	of	of	IN
cord-021419-nypnib0h	66	19	the	the	DT
cord-021419-nypnib0h	66	20	growing	grow	VBG
cord-021419-nypnib0h	66	21	peptidoglycan	peptidoglycan	NN
cord-021419-nypnib0h	66	22	chain	chain	NN
cord-021419-nypnib0h	66	23	on	on	IN
cord-021419-nypnib0h	66	24	the	the	DT
cord-021419-nypnib0h	66	25	outer	outer	JJ
cord-021419-nypnib0h	66	26	bacterial	bacterial	JJ
cord-021419-nypnib0h	66	27	cell	cell	NN
cord-021419-nypnib0h	66	28	wall	wall	NN
cord-021419-nypnib0h	66	29	,	,	,
cord-021419-nypnib0h	66	30	thereby	thereby	RB
cord-021419-nypnib0h	66	31	inhibiting	inhibit	VBG
cord-021419-nypnib0h	66	32	the	the	DT
cord-021419-nypnib0h	66	33	enzymes	enzyme	NNS
cord-021419-nypnib0h	66	34	transpeptidase	transpeptidase	NN
cord-021419-nypnib0h	66	35	and	and	CC
cord-021419-nypnib0h	66	36	transglycosylase	transglycosylase	NNP
cord-021419-nypnib0h	66	37	.	.	.
cord-021419-nypnib0h	67	1	The	the	DT
cord-021419-nypnib0h	67	2	vancomycin	vancomycin	NN
cord-021419-nypnib0h	67	3	resistance	resistance	NN
cord-021419-nypnib0h	67	4	in	in	IN
cord-021419-nypnib0h	67	5	enterococcus	enterococcus	NN
cord-021419-nypnib0h	67	6	strains	strain	NNS
cord-021419-nypnib0h	67	7	(	(	-LRB-
cord-021419-nypnib0h	67	8	VRE	VRE	NNP
cord-021419-nypnib0h	67	9	)	)	-RRB-
cord-021419-nypnib0h	67	10	(	(	-LRB-
cord-021419-nypnib0h	67	11	for	for	IN
cord-021419-nypnib0h	67	12	VanA	VanA	NNP
cord-021419-nypnib0h	67	13	and	and	CC
cord-021419-nypnib0h	67	14	VanB	VanB	NNP
cord-021419-nypnib0h	67	15	phenotypes	phenotype	NNS
cord-021419-nypnib0h	67	16	)	)	-RRB-
cord-021419-nypnib0h	67	17	arises	arise	VBZ
cord-021419-nypnib0h	67	18	due	due	IN
cord-021419-nypnib0h	67	19	to	to	IN
cord-021419-nypnib0h	67	20	replacement	replacement	NN
cord-021419-nypnib0h	67	21	of	of	IN
cord-021419-nypnib0h	67	22	the	the	DT
cord-021419-nypnib0h	67	23	D	D	NNP
cord-021419-nypnib0h	67	24	-	-	HYPH
cord-021419-nypnib0h	67	25	Ala	ala	NN
cord-021419-nypnib0h	67	26	-	-	HYPH
cord-021419-nypnib0h	67	27	D	D	NNP
cord-021419-nypnib0h	67	28	-	-	HYPH
cord-021419-nypnib0h	67	29	Ala	Ala	NNP
cord-021419-nypnib0h	67	30	group	group	NN
cord-021419-nypnib0h	67	31	by	by	IN
cord-021419-nypnib0h	67	32	D	D	NNP
cord-021419-nypnib0h	67	33	-	-	HYPH
cord-021419-nypnib0h	67	34	Ala	ala	NN
cord-021419-nypnib0h	67	35	-	-	HYPH
cord-021419-nypnib0h	67	36	D	d	NN
cord-021419-nypnib0h	67	37	-	-	HYPH
cord-021419-nypnib0h	67	38	lactate	lactate	NN
cord-021419-nypnib0h	67	39	,	,	,
cord-021419-nypnib0h	67	40	which	which	WDT
cord-021419-nypnib0h	67	41	weakly	weakly	RB
cord-021419-nypnib0h	67	42	interacts	interact	VBZ
cord-021419-nypnib0h	67	43	with	with	IN
cord-021419-nypnib0h	67	44	the	the	DT
cord-021419-nypnib0h	67	45	antibiotic	antibiotic	NN
cord-021419-nypnib0h	67	46	.	.	.
cord-021419-nypnib0h	68	1	Semi	semi	JJ
cord-021419-nypnib0h	68	2	-	-	JJ
cord-021419-nypnib0h	68	3	synthetic	synthetic	JJ
cord-021419-nypnib0h	68	4	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	68	5	analogues	analogue	NNS
cord-021419-nypnib0h	68	6	,	,	,
cord-021419-nypnib0h	68	7	such	such	JJ
cord-021419-nypnib0h	68	8	as	as	IN
cord-021419-nypnib0h	68	9	oritavancin	oritavancin	NN
cord-021419-nypnib0h	68	10	,	,	,
cord-021419-nypnib0h	68	11	telavancin	telavancin	NNS
cord-021419-nypnib0h	68	12	and	and	CC
cord-021419-nypnib0h	68	13	dalbavancin	dalbavancin	NNS
cord-021419-nypnib0h	68	14	,	,	,
cord-021419-nypnib0h	68	15	have	have	VBP
cord-021419-nypnib0h	68	16	recently	recently	RB
cord-021419-nypnib0h	68	17	been	be	VBN
cord-021419-nypnib0h	68	18	used	use	VBN
cord-021419-nypnib0h	68	19	worldwide	worldwide	RB
cord-021419-nypnib0h	68	20	in	in	IN
cord-021419-nypnib0h	68	21	medicine	medicine	NN
cord-021419-nypnib0h	68	22	.	.	.
cord-021419-nypnib0h	69	1	These	these	DT
cord-021419-nypnib0h	69	2	drugs	drug	NNS
cord-021419-nypnib0h	69	3	only	only	RB
cord-021419-nypnib0h	69	4	partially	partially	RB
cord-021419-nypnib0h	69	5	solve	solve	VB
cord-021419-nypnib0h	69	6	the	the	DT
cord-021419-nypnib0h	69	7	problem	problem	NN
cord-021419-nypnib0h	69	8	of	of	IN
cord-021419-nypnib0h	69	9	the	the	DT
cord-021419-nypnib0h	69	10	treatment	treatment	NN
cord-021419-nypnib0h	69	11	of	of	IN
cord-021419-nypnib0h	69	12	infectious	infectious	JJ
cord-021419-nypnib0h	69	13	diseases	disease	NNS
cord-021419-nypnib0h	69	14	caused	cause	VBN
cord-021419-nypnib0h	69	15	by	by	IN
cord-021419-nypnib0h	69	16	vancomycinresistant	vancomycinresistant	JJ
cord-021419-nypnib0h	69	17	enterococci	enterococci	NNS
cord-021419-nypnib0h	69	18	.	.	.
cord-021419-nypnib0h	70	1	7	7	CD
cord-021419-nypnib0h	70	2	,	,	,
cord-021419-nypnib0h	70	3	8	8	CD
cord-021419-nypnib0h	71	1	The	the	DT
cord-021419-nypnib0h	71	2	search	search	NN
cord-021419-nypnib0h	71	3	for	for	IN
cord-021419-nypnib0h	71	4	more	more	JJR
cord-021419-nypnib0h	71	5	effective	effective	JJ
cord-021419-nypnib0h	71	6	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	71	7	analogues	analogue	NNS
cord-021419-nypnib0h	71	8	is	be	VBZ
cord-021419-nypnib0h	71	9	an	an	DT
cord-021419-nypnib0h	71	10	ongoing	ongoing	JJ
cord-021419-nypnib0h	71	11	process	process	NN
cord-021419-nypnib0h	71	12	.	.	.
cord-021419-nypnib0h	72	1	7	7	CD
cord-021419-nypnib0h	72	2	±	±	NNP
cord-021419-nypnib0h	72	3	9	9	CD
cord-021419-nypnib0h	72	4	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	72	5	3	3	CD
cord-021419-nypnib0h	72	6	(	(	-LRB-
cord-021419-nypnib0h	72	7	see	see	VB
cord-021419-nypnib0h	72	8	Fig	Fig	NNP
cord-021419-nypnib0h	72	9	.	.	NNP
cord-021419-nypnib0h	72	10	1	1	CD
cord-021419-nypnib0h	72	11	)	)	-RRB-
cord-021419-nypnib0h	72	12	,	,	,
cord-021419-nypnib0h	72	13	the	the	DT
cord-021419-nypnib0h	72	14	natural	natural	JJ
cord-021419-nypnib0h	72	15	antibiotic	antibiotic	NN
cord-021419-nypnib0h	72	16	of	of	IN
cord-021419-nypnib0h	72	17	this	this	DT
cord-021419-nypnib0h	72	18	group	group	NN
cord-021419-nypnib0h	72	19	,	,	,
cord-021419-nypnib0h	72	20	was	be	VBD
cord-021419-nypnib0h	72	21	discovered	discover	VBN
cord-021419-nypnib0h	72	22	in	in	IN
cord-021419-nypnib0h	72	23	the	the	DT
cord-021419-nypnib0h	72	24	Gause	Gause	NNP
cord-021419-nypnib0h	72	25	Institute	Institute	NNP
cord-021419-nypnib0h	72	26	of	of	IN
cord-021419-nypnib0h	72	27	New	New	NNP
cord-021419-nypnib0h	72	28	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	72	29	.	.	.
cord-021419-nypnib0h	73	1	17	17	CD
cord-021419-nypnib0h	74	1	This	this	DT
cord-021419-nypnib0h	74	2	compound	compound	NN
cord-021419-nypnib0h	74	3	differs	differ	VBZ
cord-021419-nypnib0h	74	4	from	from	IN
cord-021419-nypnib0h	74	5	vancomycin	vancomycin	NN
cord-021419-nypnib0h	74	6	(	(	-LRB-
cord-021419-nypnib0h	74	7	1	1	CD
cord-021419-nypnib0h	74	8	)	)	-RRB-
cord-021419-nypnib0h	74	9	by	by	IN
cord-021419-nypnib0h	74	10	the	the	DT
cord-021419-nypnib0h	74	11	absence	absence	NN
cord-021419-nypnib0h	74	12	of	of	IN
cord-021419-nypnib0h	74	13	a	a	DT
cord-021419-nypnib0h	74	14	chlorine	chlorine	NN
cord-021419-nypnib0h	74	15	atom	atom	NN
cord-021419-nypnib0h	74	16	and	and	CC
cord-021419-nypnib0h	74	17	the	the	DT
cord-021419-nypnib0h	74	18	presence	presence	NN
cord-021419-nypnib0h	74	19	of	of	IN
cord-021419-nypnib0h	74	20	the	the	DT
cord-021419-nypnib0h	74	21	additional	additional	JJ
cord-021419-nypnib0h	74	22	amino	amino	NN
cord-021419-nypnib0h	74	23	sugar	sugar	NN
cord-021419-nypnib0h	74	24	eremosamine	eremosamine	NN
cord-021419-nypnib0h	74	25	in	in	IN
cord-021419-nypnib0h	74	26	the	the	DT
cord-021419-nypnib0h	74	27	side	side	NN
cord-021419-nypnib0h	74	28	group	group	NN
cord-021419-nypnib0h	74	29	of	of	IN
cord-021419-nypnib0h	74	30	amino	amino	NN
cord-021419-nypnib0h	74	31	acid	acid	NNP
cord-021419-nypnib0h	74	32	6	6	CD
cord-021419-nypnib0h	74	33	(	(	-LRB-
cord-021419-nypnib0h	74	34	AA6	AA6	NNP
cord-021419-nypnib0h	74	35	)	)	-RRB-
cord-021419-nypnib0h	74	36	,	,	,
cord-021419-nypnib0h	74	37	as	as	RB
cord-021419-nypnib0h	74	38	well	well	RB
cord-021419-nypnib0h	74	39	as	as	IN
cord-021419-nypnib0h	74	40	by	by	IN
cord-021419-nypnib0h	74	41	the	the	DT
cord-021419-nypnib0h	74	42	structure	structure	NN
cord-021419-nypnib0h	74	43	of	of	IN
cord-021419-nypnib0h	74	44	the	the	DT
cord-021419-nypnib0h	74	45	amino	amino	NN
cord-021419-nypnib0h	74	46	sugar	sugar	NN
cord-021419-nypnib0h	74	47	(	(	-LRB-
cord-021419-nypnib0h	74	48	4	4	CD
cord-021419-nypnib0h	74	49	H	h	NN
cord-021419-nypnib0h	74	50	-epivancosamine	-epivancosamine	NN
cord-021419-nypnib0h	74	51	or	or	CC
cord-021419-nypnib0h	74	52	eremosamine	eremosamine	NN
cord-021419-nypnib0h	74	53	)	)	-RRB-
cord-021419-nypnib0h	74	54	at	at	IN
cord-021419-nypnib0h	74	55	the	the	DT
cord-021419-nypnib0h	74	56	D	D	NNP
cord-021419-nypnib0h	74	57	-	-	HYPH
cord-021419-nypnib0h	74	58	glucopyranose	glucopyranose	NNP
cord-021419-nypnib0h	74	59	moiety	moiety	NN
cord-021419-nypnib0h	74	60	attached	attach	VBN
cord-021419-nypnib0h	74	61	to	to	IN
cord-021419-nypnib0h	74	62	AA4	AA4	NNP
cord-021419-nypnib0h	74	63	.	.	.
cord-021419-nypnib0h	75	1	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	75	2	(	(	-LRB-
cord-021419-nypnib0h	75	3	3	3	CD
cord-021419-nypnib0h	75	4	)	)	-RRB-
cord-021419-nypnib0h	75	5	is	be	VBZ
cord-021419-nypnib0h	75	6	3	3	CD
cord-021419-nypnib0h	75	7	±	±	NNP
cord-021419-nypnib0h	75	8	5	5	CD
cord-021419-nypnib0h	75	9	times	time	NNS
cord-021419-nypnib0h	75	10	more	more	RBR
cord-021419-nypnib0h	75	11	active	active	JJ
cord-021419-nypnib0h	75	12	against	against	IN
cord-021419-nypnib0h	75	13	Gram	gram	NN
cord-021419-nypnib0h	75	14	-	-	HYPH
cord-021419-nypnib0h	75	15	positive	positive	JJ
cord-021419-nypnib0h	75	16	bacteria	bacteria	NNS
cord-021419-nypnib0h	75	17	than	than	IN
cord-021419-nypnib0h	75	18	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	75	19	1	1	CD
cord-021419-nypnib0h	75	20	;	;	:
cord-021419-nypnib0h	75	21	however	however	RB
cord-021419-nypnib0h	75	22	,	,	,
cord-021419-nypnib0h	75	23	drug	drug	NN
cord-021419-nypnib0h	75	24	3	3	CD
cord-021419-nypnib0h	75	25	is	be	VBZ
cord-021419-nypnib0h	75	26	also	also	RB
cord-021419-nypnib0h	75	27	ineffective	ineffective	JJ
cord-021419-nypnib0h	75	28	against	against	IN
cord-021419-nypnib0h	75	29	VRE	VRE	NNP
cord-021419-nypnib0h	75	30	and	and	CC
cord-021419-nypnib0h	75	31	vancomycin	vancomycin	NN
cord-021419-nypnib0h	75	32	-	-	HYPH
cord-021419-nypnib0h	75	33	intermediate	intermediate	JJ
cord-021419-nypnib0h	75	34	resistant	resistant	JJ
cord-021419-nypnib0h	75	35	Staphylococcus	Staphylococcus	NNP
cord-021419-nypnib0h	75	36	aureus	aureus	NN
cord-021419-nypnib0h	75	37	(	(	-LRB-
cord-021419-nypnib0h	75	38	VISA	VISA	NNP
cord-021419-nypnib0h	75	39	)	)	-RRB-
cord-021419-nypnib0h	75	40	.	.	.
cord-021419-nypnib0h	76	1	In	in	IN
cord-021419-nypnib0h	76	2	recent	recent	JJ
cord-021419-nypnib0h	76	3	years	year	NNS
cord-021419-nypnib0h	76	4	,	,	,
cord-021419-nypnib0h	76	5	series	series	NN
cord-021419-nypnib0h	76	6	of	of	IN
cord-021419-nypnib0h	76	7	new	new	JJ
cord-021419-nypnib0h	76	8	semi	semi	JJ
cord-021419-nypnib0h	76	9	-	-	JJ
cord-021419-nypnib0h	76	10	synthetic	synthetic	JJ
cord-021419-nypnib0h	76	11	derivatives	derivative	NNS
cord-021419-nypnib0h	76	12	of	of	IN
cord-021419-nypnib0h	76	13	eremomycin	eremomycin	NNS
cord-021419-nypnib0h	76	14	,	,	,
cord-021419-nypnib0h	76	15	vancomycin	vancomycin	NN
cord-021419-nypnib0h	76	16	and	and	CC
cord-021419-nypnib0h	76	17	teicoplanin	teicoplanin	NNS
cord-021419-nypnib0h	76	18	active	active	JJ
cord-021419-nypnib0h	76	19	against	against	IN
cord-021419-nypnib0h	76	20	resistant	resistant	JJ
cord-021419-nypnib0h	76	21	VRE	VRE	NNP
cord-021419-nypnib0h	76	22	and	and	CC
cord-021419-nypnib0h	76	23	VISA	VISA	NNP
cord-021419-nypnib0h	76	24	strains	strain	NNS
cord-021419-nypnib0h	76	25	were	be	VBD
cord-021419-nypnib0h	76	26	prepared	prepare	VBN
cord-021419-nypnib0h	76	27	.	.	.
cord-021419-nypnib0h	77	1	8	8	CD
cord-021419-nypnib0h	77	2	±	±	CD
cord-021419-nypnib0h	77	3	10	10	CD
cord-021419-nypnib0h	77	4	Figure	figure	NN
cord-021419-nypnib0h	77	5	 	 	_SP
cord-021419-nypnib0h	77	6	1	1	CD
cord-021419-nypnib0h	77	7	presents	present	VBZ
cord-021419-nypnib0h	77	8	main	main	JJ
cord-021419-nypnib0h	77	9	possible	possible	JJ
cord-021419-nypnib0h	77	10	directions	direction	NNS
cord-021419-nypnib0h	77	11	of	of	IN
cord-021419-nypnib0h	77	12	modification	modification	NN
cord-021419-nypnib0h	77	13	of	of	IN
cord-021419-nypnib0h	77	14	the	the	DT
cord-021419-nypnib0h	77	15	Cand	Cand	NNP
cord-021419-nypnib0h	77	16	N	N	NNP
cord-021419-nypnib0h	77	17	-	-	HYPH
cord-021419-nypnib0h	77	18	terminal	terminal	NN
cord-021419-nypnib0h	77	19	groups	group	NNS
cord-021419-nypnib0h	77	20	of	of	IN
cord-021419-nypnib0h	77	21	the	the	DT
cord-021419-nypnib0h	77	22	peptide	peptide	NN
cord-021419-nypnib0h	77	23	core	core	NN
cord-021419-nypnib0h	77	24	(	(	-LRB-
cord-021419-nypnib0h	77	25	a	a	NN
cord-021419-nypnib0h	77	26	and	and	CC
cord-021419-nypnib0h	77	27	f	f	NNP
cord-021419-nypnib0h	77	28	)	)	-RRB-
cord-021419-nypnib0h	77	29	,	,	,
cord-021419-nypnib0h	77	30	3	3	CD
cord-021419-nypnib0h	77	31	H	h	NN
cord-021419-nypnib0h	77	32	-amino	-amino	HYPH
cord-021419-nypnib0h	77	33	sugar	sugar	NN
cord-021419-nypnib0h	77	34	(	(	-LRB-
cord-021419-nypnib0h	77	35	b	b	NN
cord-021419-nypnib0h	77	36	)	)	-RRB-
cord-021419-nypnib0h	77	37	,	,	,
cord-021419-nypnib0h	77	38	the	the	DT
cord-021419-nypnib0h	77	39	amide	amide	NN
cord-021419-nypnib0h	77	40	group	group	NN
cord-021419-nypnib0h	77	41	of	of	IN
cord-021419-nypnib0h	77	42	asparagine	asparagine	NN
cord-021419-nypnib0h	77	43	(	(	-LRB-
cord-021419-nypnib0h	77	44	Asn	Asn	NNP
cord-021419-nypnib0h	77	45	)	)	-RRB-
cord-021419-nypnib0h	77	46	(	(	-LRB-
cord-021419-nypnib0h	77	47	c	c	NNP
cord-021419-nypnib0h	77	48	)	)	-RRB-
cord-021419-nypnib0h	77	49	,	,	,
cord-021419-nypnib0h	77	50	sugar	sugar	NN
cord-021419-nypnib0h	77	51	elimination	elimination	NN
cord-021419-nypnib0h	77	52	(	(	-LRB-
cord-021419-nypnib0h	77	53	d	d	NN
cord-021419-nypnib0h	77	54	)	)	-RRB-
cord-021419-nypnib0h	77	55	and	and	CC
cord-021419-nypnib0h	77	56	Edman	Edman	NNP
cord-021419-nypnib0h	77	57	degradation	degradation	NN
cord-021419-nypnib0h	77	58	(	(	-LRB-
cord-021419-nypnib0h	77	59	e	e	LS
cord-021419-nypnib0h	77	60	)	)	-RRB-
cord-021419-nypnib0h	77	61	for	for	IN
cord-021419-nypnib0h	77	62	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	77	63	1	1	CD
cord-021419-nypnib0h	77	64	±	±	CD
cord-021419-nypnib0h	77	65	3	3	CD
cord-021419-nypnib0h	77	66	.	.	.
cord-021419-nypnib0h	78	1	the	the	DT
cord-021419-nypnib0h	78	2	presence	presence	NN
cord-021419-nypnib0h	78	3	of	of	IN
cord-021419-nypnib0h	78	4	(	(	-LRB-
cord-021419-nypnib0h	78	5	benzotriazol-1-yl)oxytripyrrolidinophosphonium	benzotriazol-1-yl)oxytripyrrolidinophosphonium	NNP
cord-021419-nypnib0h	78	6	hexafluorophosphate	hexafluorophosphate	NNP
cord-021419-nypnib0h	78	7	(	(	-LRB-
cord-021419-nypnib0h	78	8	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	78	9	)	)	-RRB-
cord-021419-nypnib0h	78	10	as	as	IN
cord-021419-nypnib0h	78	11	the	the	DT
cord-021419-nypnib0h	78	12	peptide	peptide	NN
cord-021419-nypnib0h	78	13	coupling	coupling	NN
cord-021419-nypnib0h	78	14	reagent	reagent	NN
cord-021419-nypnib0h	78	15	afforded	afford	VBD
cord-021419-nypnib0h	78	16	a	a	DT
cord-021419-nypnib0h	78	17	series	series	NN
cord-021419-nypnib0h	78	18	of	of	IN
cord-021419-nypnib0h	78	19	new	new	JJ
cord-021419-nypnib0h	78	20	carboxamide	carboxamide	JJ
cord-021419-nypnib0h	78	21	derivatives	derivative	NNS
cord-021419-nypnib0h	78	22	of	of	IN
cord-021419-nypnib0h	78	23	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	78	24	4	4	CD
cord-021419-nypnib0h	78	25	±	±	CD
cord-021419-nypnib0h	78	26	6	6	CD
cord-021419-nypnib0h	79	1	(	(	-LRB-
cord-021419-nypnib0h	79	2	Scheme	scheme	NN
cord-021419-nypnib0h	79	3	1	1	CD
cord-021419-nypnib0h	79	4	,	,	,
cord-021419-nypnib0h	79	5	Fig	Fig	NNP
cord-021419-nypnib0h	79	6	.	.	NNP
cord-021419-nypnib0h	79	7	1	1	CD
cord-021419-nypnib0h	79	8	a3	a3	NNP
cord-021419-nypnib0h	79	9	)	)	-RRB-
cord-021419-nypnib0h	79	10	.	.	.
cord-021419-nypnib0h	80	1	11	11	CD
cord-021419-nypnib0h	80	2	±	±	CD
cord-021419-nypnib0h	80	3	14	14	CD
cord-021419-nypnib0h	81	1	After	after	IN
cord-021419-nypnib0h	81	2	the	the	DT
cord-021419-nypnib0h	81	3	purification	purification	NN
cord-021419-nypnib0h	81	4	,	,	,
cord-021419-nypnib0h	81	5	these	these	DT
cord-021419-nypnib0h	81	6	compounds	compound	NNS
cord-021419-nypnib0h	81	7	were	be	VBD
cord-021419-nypnib0h	81	8	isolated	isolate	VBN
cord-021419-nypnib0h	81	9	in	in	IN
cord-021419-nypnib0h	81	10	*	*	NFP
cord-021419-nypnib0h	81	11	50	50	CD
cord-021419-nypnib0h	81	12	%	%	NN
cord-021419-nypnib0h	81	13	±	±	CD
cord-021419-nypnib0h	81	14	80	80	CD
cord-021419-nypnib0h	81	15	%	%	NN
cord-021419-nypnib0h	81	16	yields	yield	NNS
cord-021419-nypnib0h	81	17	.	.	.
cord-021419-nypnib0h	82	1	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	82	2	pyrrolidide	pyrrolidide	NN
cord-021419-nypnib0h	82	3	(	(	-LRB-
cord-021419-nypnib0h	82	4	4	4	LS
cord-021419-nypnib0h	82	5	)	)	-RRB-
cord-021419-nypnib0h	82	6	has	have	VBZ
cord-021419-nypnib0h	82	7	high	high	JJ
cord-021419-nypnib0h	82	8	in	in	IN
cord-021419-nypnib0h	82	9	vitro	vitro	FW
cord-021419-nypnib0h	82	10	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	82	11	activity	activity	NN
cord-021419-nypnib0h	82	12	against	against	IN
cord-021419-nypnib0h	82	13	sensitive	sensitive	JJ
cord-021419-nypnib0h	82	14	and	and	CC
cord-021419-nypnib0h	82	15	resistant	resistant	JJ
cord-021419-nypnib0h	82	16	Gram	gram	NN
cord-021419-nypnib0h	82	17	-	-	HYPH
cord-021419-nypnib0h	82	18	positive	positive	JJ
cord-021419-nypnib0h	82	19	bacterial	bacterial	JJ
cord-021419-nypnib0h	82	20	strains	strain	NNS
cord-021419-nypnib0h	82	21	,	,	,
cord-021419-nypnib0h	82	22	including	include	VBG
cord-021419-nypnib0h	82	23	MRSA	MRSA	NNP
cord-021419-nypnib0h	82	24	,	,	,
cord-021419-nypnib0h	82	25	VISA	VISA	NNP
cord-021419-nypnib0h	82	26	and	and	CC
cord-021419-nypnib0h	82	27	VRE	VRE	NNP
cord-021419-nypnib0h	82	28	isolates	isolate	VBZ
cord-021419-nypnib0h	82	29	.	.	.
cord-021419-nypnib0h	83	1	13	13	CD
cord-021419-nypnib0h	84	1	,	,	,
cord-021419-nypnib0h	84	2	14	14	CD
cord-021419-nypnib0h	85	1	Besides	besides	RB
cord-021419-nypnib0h	85	2	,	,	,
cord-021419-nypnib0h	85	3	compound	compound	NN
cord-021419-nypnib0h	85	4	4	4	CD
cord-021419-nypnib0h	85	5	is	be	VBZ
cord-021419-nypnib0h	85	6	much	much	RB
cord-021419-nypnib0h	85	7	more	more	RBR
cord-021419-nypnib0h	85	8	effective	effective	JJ
cord-021419-nypnib0h	85	9	in	in	IN
cord-021419-nypnib0h	85	10	the	the	DT
cord-021419-nypnib0h	85	11	treatment	treatment	NN
cord-021419-nypnib0h	85	12	of	of	IN
cord-021419-nypnib0h	85	13	induced	induce	VBN
cord-021419-nypnib0h	85	14	sepsis	sepsis	NN
cord-021419-nypnib0h	85	15	in	in	IN
cord-021419-nypnib0h	85	16	mice	mouse	NNS
cord-021419-nypnib0h	85	17	compared	compare	VBN
cord-021419-nypnib0h	85	18	to	to	IN
cord-021419-nypnib0h	85	19	vancomycin	vancomycin	FW
cord-021419-nypnib0h	85	20	(	(	-LRB-
cord-021419-nypnib0h	85	21	1	1	CD
cord-021419-nypnib0h	85	22	)	)	-RRB-
cord-021419-nypnib0h	85	23	and	and	CC
cord-021419-nypnib0h	85	24	does	do	VBZ
cord-021419-nypnib0h	85	25	not	not	RB
cord-021419-nypnib0h	85	26	cause	cause	VB
cord-021419-nypnib0h	85	27	a	a	DT
cord-021419-nypnib0h	85	28	pseudoallergic	pseudoallergic	JJ
cord-021419-nypnib0h	85	29	reaction	reaction	NN
cord-021419-nypnib0h	85	30	typical	typical	JJ
cord-021419-nypnib0h	85	31	of	of	IN
cord-021419-nypnib0h	85	32	many	many	JJ
cord-021419-nypnib0h	85	33	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	85	34	of	of	IN
cord-021419-nypnib0h	85	35	this	this	DT
cord-021419-nypnib0h	85	36	group	group	NN
cord-021419-nypnib0h	85	37	.	.	.
cord-021419-nypnib0h	86	1	Compound	compound	NN
cord-021419-nypnib0h	86	2	4	4	CD
cord-021419-nypnib0h	86	3	was	be	VBD
cord-021419-nypnib0h	86	4	successful	successful	JJ
cord-021419-nypnib0h	86	5	in	in	IN
cord-021419-nypnib0h	86	6	preclinical	preclinical	JJ
cord-021419-nypnib0h	86	7	evaluation	evaluation	NN
cord-021419-nypnib0h	86	8	(	(	-LRB-
cord-021419-nypnib0h	86	9	in	in	IN
cord-021419-nypnib0h	86	10	collaboration	collaboration	NN
cord-021419-nypnib0h	86	11	with	with	IN
cord-021419-nypnib0h	86	12	the	the	DT
cord-021419-nypnib0h	86	13	Limited	Limited	NNP
cord-021419-nypnib0h	86	14	Liability	Liability	NNP
cord-021419-nypnib0h	86	15	Company`Medicine	company`medicine	IN
cord-021419-nypnib0h	86	16	Technology	Technology	NNP
cord-021419-nypnib0h	86	17	'	'	''
cord-021419-nypnib0h	86	18	)	)	-RRB-
cord-021419-nypnib0h	86	19	and	and	CC
cord-021419-nypnib0h	86	20	was	be	VBD
cord-021419-nypnib0h	86	21	recommended	recommend	VBN
cord-021419-nypnib0h	86	22	for	for	IN
cord-021419-nypnib0h	86	23	further	further	JJ
cord-021419-nypnib0h	86	24	clinical	clinical	JJ
cord-021419-nypnib0h	86	25	trials	trial	NNS
cord-021419-nypnib0h	86	26	.	.	.
cord-021419-nypnib0h	87	1	13	13	CD
cord-021419-nypnib0h	88	1	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	88	2	N	N	NNP
cord-021419-nypnib0h	88	3	-	-	HYPH
cord-021419-nypnib0h	88	4	adamantan-2-ylamide	adamantan-2-ylamide	NN
cord-021419-nypnib0h	88	5	(	(	-LRB-
cord-021419-nypnib0h	88	6	5	5	CD
cord-021419-nypnib0h	88	7	)	)	-RRB-
cord-021419-nypnib0h	88	8	was	be	VBD
cord-021419-nypnib0h	88	9	synthesized	synthesize	VBN
cord-021419-nypnib0h	88	10	in	in	IN
cord-021419-nypnib0h	88	11	a	a	DT
cord-021419-nypnib0h	88	12	similar	similar	JJ
cord-021419-nypnib0h	88	13	way	way	NN
cord-021419-nypnib0h	88	14	as	as	IN
cord-021419-nypnib0h	88	15	amide	amide	NN
cord-021419-nypnib0h	88	16	4	4	CD
cord-021419-nypnib0h	88	17	(	(	-LRB-
cord-021419-nypnib0h	88	18	see	see	VB
cord-021419-nypnib0h	88	19	Scheme	scheme	NN
cord-021419-nypnib0h	88	20	1	1	CD
cord-021419-nypnib0h	88	21	)	)	-RRB-
cord-021419-nypnib0h	88	22	.	.	.
cord-021419-nypnib0h	89	1	15	15	CD
cord-021419-nypnib0h	90	1	In	in	IN
cord-021419-nypnib0h	90	2	in	in	FW
cord-021419-nypnib0h	90	3	vitro	vitro	FW
cord-021419-nypnib0h	90	4	assays	assay	NNS
cord-021419-nypnib0h	90	5	,	,	,
cord-021419-nypnib0h	90	6	compound	compound	NN
cord-021419-nypnib0h	90	7	5	5	CD
cord-021419-nypnib0h	90	8	exhibits	exhibit	VBZ
cord-021419-nypnib0h	90	9	activity	activity	NN
cord-021419-nypnib0h	90	10	against	against	IN
cord-021419-nypnib0h	90	11	MRSA	MRSA	NNP
cord-021419-nypnib0h	90	12	,	,	,
cord-021419-nypnib0h	90	13	VISA	VISA	NNP
cord-021419-nypnib0h	90	14	,	,	,
cord-021419-nypnib0h	90	15	VRE	VRE	NNP
cord-021419-nypnib0h	90	16	and	and	CC
cord-021419-nypnib0h	90	17	Bacillus	Bacillus	NNP
cord-021419-nypnib0h	90	18	anthracis	anthracis	NN
cord-021419-nypnib0h	90	19	strains	strain	VBZ
cord-021419-nypnib0h	90	20	.	.	.
cord-021419-nypnib0h	91	1	This	this	DT
cord-021419-nypnib0h	91	2	compound	compound	NN
cord-021419-nypnib0h	91	3	is	be	VBZ
cord-021419-nypnib0h	91	4	also	also	RB
cord-021419-nypnib0h	91	5	effective	effective	JJ
cord-021419-nypnib0h	91	6	against	against	IN
cord-021419-nypnib0h	91	7	ciprofloxacin	ciprofloxacin	NN
cord-021419-nypnib0h	91	8	-	-	HYPH
cord-021419-nypnib0h	91	9	resistant	resistant	JJ
cord-021419-nypnib0h	91	10	strains	strain	NNS
cord-021419-nypnib0h	91	11	of	of	IN
cord-021419-nypnib0h	91	12	Bacillus	bacillus	NN
cord-021419-nypnib0h	91	13	anthracis	anthracis	NN
cord-021419-nypnib0h	91	14	.	.	.
cord-021419-nypnib0h	92	1	Model	model	NN
cord-021419-nypnib0h	92	2	in	in	IN
cord-021419-nypnib0h	92	3	vivo	vivo	NN
cord-021419-nypnib0h	92	4	assays	assay	NNS
cord-021419-nypnib0h	92	5	in	in	IN
cord-021419-nypnib0h	92	6	mice	mouse	NNS
cord-021419-nypnib0h	92	7	infected	infect	VBN
cord-021419-nypnib0h	92	8	with	with	IN
cord-021419-nypnib0h	92	9	S.	S.	NNP
cord-021419-nypnib0h	92	10	aureus	aureus	NN
cord-021419-nypnib0h	92	11	or	or	CC
cord-021419-nypnib0h	92	12	Bacillus	Bacillus	NNP
cord-021419-nypnib0h	92	13	anthracis	anthraci	NNS
cord-021419-nypnib0h	92	14	showed	show	VBD
cord-021419-nypnib0h	92	15	that	that	IN
cord-021419-nypnib0h	92	16	compound	compound	NN
cord-021419-nypnib0h	92	17	5	5	CD
cord-021419-nypnib0h	92	18	provides	provide	VBZ
cord-021419-nypnib0h	92	19	a	a	DT
cord-021419-nypnib0h	92	20	higher	high	JJR
cord-021419-nypnib0h	92	21	survival	survival	NN
cord-021419-nypnib0h	92	22	rate	rate	NN
cord-021419-nypnib0h	92	23	of	of	IN
cord-021419-nypnib0h	92	24	animals	animal	NNS
cord-021419-nypnib0h	92	25	compared	compare	VBN
cord-021419-nypnib0h	92	26	to	to	IN
cord-021419-nypnib0h	92	27	ciprofloxacin	ciprofloxacin	NN
cord-021419-nypnib0h	92	28	and	and	CC
cord-021419-nypnib0h	92	29	has	have	VBZ
cord-021419-nypnib0h	92	30	pharmacologically	pharmacologically	RB
cord-021419-nypnib0h	92	31	relevant	relevant	JJ
cord-021419-nypnib0h	92	32	properties	property	NNS
cord-021419-nypnib0h	92	33	,	,	,
cord-021419-nypnib0h	92	34	exhibiting	exhibit	VBG
cord-021419-nypnib0h	92	35	an	an	DT
cord-021419-nypnib0h	92	36	excellent	excellent	JJ
cord-021419-nypnib0h	92	37	distribution	distribution	NN
cord-021419-nypnib0h	92	38	in	in	IN
cord-021419-nypnib0h	92	39	tissues	tissue	NNS
cord-021419-nypnib0h	92	40	.	.	.
cord-021419-nypnib0h	93	1	The	the	DT
cord-021419-nypnib0h	93	2	synthesis	synthesis	NN
cord-021419-nypnib0h	93	3	of	of	IN
cord-021419-nypnib0h	93	4	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	93	5	carboxamides	carboxamides	NNP
cord-021419-nypnib0h	93	6	containing	contain	VBG
cord-021419-nypnib0h	93	7	bulky	bulky	JJ
cord-021419-nypnib0h	93	8	substituents	substituent	NNS
cord-021419-nypnib0h	93	9	,	,	,
cord-021419-nypnib0h	93	10	such	such	JJ
cord-021419-nypnib0h	93	11	as	as	IN
cord-021419-nypnib0h	93	12	2-aminoadamantane	2-aminoadamantane	CD
cord-021419-nypnib0h	93	13	(	(	-LRB-
cord-021419-nypnib0h	93	14	2-Ad	2-ad	CD
cord-021419-nypnib0h	93	15	)	)	-RRB-
cord-021419-nypnib0h	93	16	(	(	-LRB-
cord-021419-nypnib0h	93	17	compound	compound	NNP
cord-021419-nypnib0h	93	18	5	5	CD
cord-021419-nypnib0h	93	19	)	)	-RRB-
cord-021419-nypnib0h	93	20	,	,	,
cord-021419-nypnib0h	93	21	in	in	IN
cord-021419-nypnib0h	93	22	the	the	DT
cord-021419-nypnib0h	93	23	presence	presence	NN
cord-021419-nypnib0h	93	24	of	of	IN
cord-021419-nypnib0h	93	25	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	93	26	at	at	IN
cord-021419-nypnib0h	93	27	pH	pH	NNP
cord-021419-nypnib0h	93	28	*	*	NFP
cord-021419-nypnib0h	93	29	8.5	8.5	CD
cord-021419-nypnib0h	93	30	afforded	afford	VBD
cord-021419-nypnib0h	93	31	the	the	DT
cord-021419-nypnib0h	93	32	previously	previously	RB
cord-021419-nypnib0h	93	33	characterized	characterize	VBN
cord-021419-nypnib0h	93	34	unsubstituted	unsubstitute	VBN
cord-021419-nypnib0h	93	35	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	93	36	amide	amide	NN
cord-021419-nypnib0h	93	37	(	(	-LRB-
cord-021419-nypnib0h	93	38	6	6	CD
cord-021419-nypnib0h	93	39	)	)	-RRB-
cord-021419-nypnib0h	93	40	as	as	IN
cord-021419-nypnib0h	93	41	a	a	DT
cord-021419-nypnib0h	93	42	by	by	IN
cord-021419-nypnib0h	93	43	-	-	HYPH
cord-021419-nypnib0h	93	44	product	product	NN
cord-021419-nypnib0h	93	45	.	.	.
cord-021419-nypnib0h	94	1	16	16	CD
cord-021419-nypnib0h	94	2	Compound	Compound	NNP
cord-021419-nypnib0h	94	3	6	6	CD
cord-021419-nypnib0h	94	4	is	be	VBZ
cord-021419-nypnib0h	94	5	produced	produce	VBN
cord-021419-nypnib0h	94	6	by	by	IN
cord-021419-nypnib0h	94	7	the	the	DT
cord-021419-nypnib0h	94	8	competitive	competitive	JJ
cord-021419-nypnib0h	94	9	amidation	amidation	NN
cord-021419-nypnib0h	94	10	reaction	reaction	NN
cord-021419-nypnib0h	94	11	of	of	IN
cord-021419-nypnib0h	94	12	the	the	DT
cord-021419-nypnib0h	94	13	antibiotic	antibiotic	NN
cord-021419-nypnib0h	94	14	with	with	IN
cord-021419-nypnib0h	94	15	ammonia	ammonia	NN
cord-021419-nypnib0h	94	16	,	,	,
cord-021419-nypnib0h	94	17	which	which	WDT
cord-021419-nypnib0h	94	18	is	be	VBZ
cord-021419-nypnib0h	94	19	eliminated	eliminate	VBN
cord-021419-nypnib0h	94	20	through	through	IN
cord-021419-nypnib0h	94	21	transpeptidation	transpeptidation	NN
cord-021419-nypnib0h	94	22	of	of	IN
cord-021419-nypnib0h	94	23	asparagine	asparagine	NN
cord-021419-nypnib0h	94	24	-	-	HYPH
cord-021419-nypnib0h	94	25	containing	contain	VBG
cord-021419-nypnib0h	94	26	peptides	peptide	NNS
cord-021419-nypnib0h	94	27	in	in	IN
cord-021419-nypnib0h	94	28	an	an	DT
cord-021419-nypnib0h	94	29	alkaline	alkaline	JJ
cord-021419-nypnib0h	94	30	medium	medium	NN
cord-021419-nypnib0h	94	31	.	.	.
cord-021419-nypnib0h	95	1	An	an	DT
cord-021419-nypnib0h	95	2	original	original	JJ
cord-021419-nypnib0h	95	3	method	method	NN
cord-021419-nypnib0h	95	4	was	be	VBD
cord-021419-nypnib0h	95	5	developed	develop	VBN
cord-021419-nypnib0h	95	6	for	for	IN
cord-021419-nypnib0h	95	7	the	the	DT
cord-021419-nypnib0h	95	8	selective	selective	JJ
cord-021419-nypnib0h	95	9	introduction	introduction	NN
cord-021419-nypnib0h	95	10	of	of	IN
cord-021419-nypnib0h	95	11	different	different	JJ
cord-021419-nypnib0h	95	12	amino	amino	NN
cord-021419-nypnib0h	95	13	acids	acid	NNS
cord-021419-nypnib0h	95	14	containing	contain	VBG
cord-021419-nypnib0h	95	15	a	a	DT
cord-021419-nypnib0h	95	16	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	95	17	substituent	substituent	NN
cord-021419-nypnib0h	95	18	into	into	IN
cord-021419-nypnib0h	95	19	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	95	20	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	95	21	1	1	CD
cord-021419-nypnib0h	95	22	or	or	CC
cord-021419-nypnib0h	95	23	2	2	CD
cord-021419-nypnib0h	95	24	via	via	IN
cord-021419-nypnib0h	95	25	selective	selective	JJ
cord-021419-nypnib0h	95	26	aminoacylation	aminoacylation	NN
cord-021419-nypnib0h	95	27	of	of	IN
cord-021419-nypnib0h	95	28	the	the	DT
cord-021419-nypnib0h	95	29	3	3	CD
cord-021419-nypnib0h	95	30	H	h	NN
cord-021419-nypnib0h	95	31	-amino	-amino	HYPH
cord-021419-nypnib0h	95	32	group	group	NN
cord-021419-nypnib0h	95	33	of	of	IN
cord-021419-nypnib0h	95	34	the	the	DT
cord-021419-nypnib0h	95	35	amino	amino	NN
cord-021419-nypnib0h	95	36	sugar	sugar	NN
cord-021419-nypnib0h	95	37	moiety	moiety	NN
cord-021419-nypnib0h	95	38	of	of	IN
cord-021419-nypnib0h	95	39	the	the	DT
cord-021419-nypnib0h	95	40	disaccharide	disaccharide	JJ
cord-021419-nypnib0h	95	41	branch	branch	NN
cord-021419-nypnib0h	95	42	.	.	.
cord-021419-nypnib0h	96	1	17	17	CD
cord-021419-nypnib0h	97	1	For	for	IN
cord-021419-nypnib0h	97	2	instance	instance	NN
cord-021419-nypnib0h	97	3	,	,	,
cord-021419-nypnib0h	97	4	the	the	DT
cord-021419-nypnib0h	97	5	reaction	reaction	NN
cord-021419-nypnib0h	97	6	of	of	IN
cord-021419-nypnib0h	97	7	vancomycin	vancomycin	NN
cord-021419-nypnib0h	97	8	1	1	CD
cord-021419-nypnib0h	97	9	with	with	IN
cord-021419-nypnib0h	97	10	N	n	CD
cord-021419-nypnib0h	97	11	-	-	HYPH
cord-021419-nypnib0h	97	12	Fmoc-(N	Fmoc-(N	NNP
cord-021419-nypnib0h	97	13	-	-	HYPH
cord-021419-nypnib0h	97	14	n	n	JJ
cord-021419-nypnib0h	97	15	-	-	HYPH
cord-021419-nypnib0h	97	16	octyl	octyl	NNP
cord-021419-nypnib0h	97	17	-	-	HYPH
cord-021419-nypnib0h	97	18	O-4benzyl)-L	O-4benzyl)-L	NNP
cord-021419-nypnib0h	97	19	-	-	HYPH
cord-021419-nypnib0h	97	20	alanine	alanine	NNP
cord-021419-nypnib0h	97	21	N	N	NNP
cord-021419-nypnib0h	97	22	-	-	HYPH
cord-021419-nypnib0h	97	23	hydroxysuccinimide	hydroxysuccinimide	NNP
cord-021419-nypnib0h	97	24	(	(	-LRB-
cord-021419-nypnib0h	97	25	OSu	OSu	NNS
cord-021419-nypnib0h	97	26	)	)	-RRB-
cord-021419-nypnib0h	97	27	ester	ester	NNP
cord-021419-nypnib0h	97	28	gave	give	VBD
cord-021419-nypnib0h	97	29	Figure	Figure	NNP
cord-021419-nypnib0h	97	30	1	1	CD
cord-021419-nypnib0h	97	31	.	.	.
cord-021419-nypnib0h	98	1	Structures	structure	NNS
cord-021419-nypnib0h	98	2	of	of	IN
cord-021419-nypnib0h	98	3	vancomycin	vancomycin	NNS
cord-021419-nypnib0h	98	4	(	(	-LRB-
cord-021419-nypnib0h	98	5	1	1	CD
cord-021419-nypnib0h	98	6	)	)	-RRB-
cord-021419-nypnib0h	98	7	,	,	,
cord-021419-nypnib0h	98	8	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	98	9	A2	A2	NNP
cord-021419-nypnib0h	98	10	-	-	HYPH
cord-021419-nypnib0h	98	11	2	2	NNP
cord-021419-nypnib0h	98	12	(	(	-LRB-
cord-021419-nypnib0h	98	13	2	2	CD
cord-021419-nypnib0h	98	14	)	)	-RRB-
cord-021419-nypnib0h	98	15	and	and	CC
cord-021419-nypnib0h	98	16	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	98	17	(	(	-LRB-
cord-021419-nypnib0h	98	18	3	3	CD
cord-021419-nypnib0h	98	19	)	)	-RRB-
cord-021419-nypnib0h	98	20	and	and	CC
cord-021419-nypnib0h	98	21	directions	direction	NNS
cord-021419-nypnib0h	98	22	of	of	IN
cord-021419-nypnib0h	98	23	their	-PRON-	PRP$
cord-021419-nypnib0h	98	24	chemical	chemical	NN
cord-021419-nypnib0h	98	25	modifications	modification	NNS
cord-021419-nypnib0h	98	26	:	:	:
cord-021419-nypnib0h	99	1	amidation	amidation	NNP
cord-021419-nypnib0h	99	2	(	(	-LRB-
cord-021419-nypnib0h	99	3	a	a	LS
cord-021419-nypnib0h	99	4	)	)	-RRB-
cord-021419-nypnib0h	99	5	,	,	,
cord-021419-nypnib0h	99	6	acylation	acylation	NN
cord-021419-nypnib0h	99	7	(	(	-LRB-
cord-021419-nypnib0h	99	8	b	b	NN
cord-021419-nypnib0h	99	9	)	)	-RRB-
cord-021419-nypnib0h	99	10	,	,	,
cord-021419-nypnib0h	99	11	alkaline	alkaline	JJ
cord-021419-nypnib0h	99	12	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	99	13	of	of	IN
cord-021419-nypnib0h	99	14	the	the	DT
cord-021419-nypnib0h	99	15	C(O)NH2	C(O)NH2	NNP
cord-021419-nypnib0h	99	16	group	group	NN
cord-021419-nypnib0h	99	17	to	to	IN
cord-021419-nypnib0h	99	18	CO2H	CO2H	NNP
cord-021419-nypnib0h	99	19	followed	follow	VBN
cord-021419-nypnib0h	99	20	by	by	IN
cord-021419-nypnib0h	99	21	amidation	amidation	NN
cord-021419-nypnib0h	99	22	(	(	-LRB-
cord-021419-nypnib0h	99	23	c	c	NNP
cord-021419-nypnib0h	99	24	)	)	-RRB-
cord-021419-nypnib0h	99	25	,	,	,
cord-021419-nypnib0h	99	26	sugar	sugar	NN
cord-021419-nypnib0h	99	27	elimination	elimination	NN
cord-021419-nypnib0h	99	28	(	(	-LRB-
cord-021419-nypnib0h	99	29	d	d	NNP
cord-021419-nypnib0h	99	30	)	)	-RRB-
cord-021419-nypnib0h	99	31	,	,	,
cord-021419-nypnib0h	99	32	Edman	Edman	NNP
cord-021419-nypnib0h	99	33	degradation	degradation	NN
cord-021419-nypnib0h	99	34	(	(	-LRB-
cord-021419-nypnib0h	99	35	e	e	NN
cord-021419-nypnib0h	99	36	)	)	-RRB-
cord-021419-nypnib0h	99	37	and	and	CC
cord-021419-nypnib0h	99	38	modification	modification	NN
cord-021419-nypnib0h	99	39	of	of	IN
cord-021419-nypnib0h	99	40	the	the	DT
cord-021419-nypnib0h	99	41	N	n	CD
cord-021419-nypnib0h	99	42	-	-	HYPH
cord-021419-nypnib0h	99	43	terminal	terminal	JJ
cord-021419-nypnib0h	99	44	amino	amino	NN
cord-021419-nypnib0h	99	45	group	group	NN
cord-021419-nypnib0h	99	46	of	of	IN
cord-021419-nypnib0h	99	47	the	the	DT
cord-021419-nypnib0h	99	48	peptide	peptide	NN
cord-021419-nypnib0h	99	49	core	core	NN
cord-021419-nypnib0h	99	50	(	(	-LRB-
cord-021419-nypnib0h	99	51	f	f	NNP
cord-021419-nypnib0h	99	52	)	)	-RRB-
cord-021419-nypnib0h	99	53	.	.	.
cord-021419-nypnib0h	100	1	Fig	fig	NN
cord-021419-nypnib0h	100	2	.	.	.
cord-021419-nypnib0h	100	3	1	1	CD
cord-021419-nypnib0h	100	4	b1	b1	NN
cord-021419-nypnib0h	100	5	)	)	-RRB-
cord-021419-nypnib0h	100	6	.	.	.
cord-021419-nypnib0h	101	1	In	in	IN
cord-021419-nypnib0h	101	2	this	this	DT
cord-021419-nypnib0h	101	3	reaction	reaction	NN
cord-021419-nypnib0h	101	4	,	,	,
cord-021419-nypnib0h	101	5	the	the	DT
cord-021419-nypnib0h	101	6	N	n	CD
cord-021419-nypnib0h	101	7	-	-	HYPH
cord-021419-nypnib0h	101	8	terminal	terminal	NN
cord-021419-nypnib0h	101	9	group	group	NN
cord-021419-nypnib0h	101	10	of	of	IN
cord-021419-nypnib0h	101	11	the	the	DT
cord-021419-nypnib0h	101	12	peptide	peptide	NN
cord-021419-nypnib0h	101	13	core	core	NN
cord-021419-nypnib0h	101	14	of	of	IN
cord-021419-nypnib0h	101	15	the	the	DT
cord-021419-nypnib0h	101	16	antibiotic	antibiotic	NN
cord-021419-nypnib0h	101	17	remains	remain	VBZ
cord-021419-nypnib0h	101	18	intact	intact	JJ
cord-021419-nypnib0h	101	19	.	.	.
cord-021419-nypnib0h	102	1	The	the	DT
cord-021419-nypnib0h	102	2	N	N	NNP
cord-021419-nypnib0h	102	3	-	-	HYPH
cord-021419-nypnib0h	102	4	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	102	5	protecting	protect	VBG
cord-021419-nypnib0h	102	6	group	group	NN
cord-021419-nypnib0h	102	7	can	can	MD
cord-021419-nypnib0h	102	8	easily	easily	RB
cord-021419-nypnib0h	102	9	be	be	VB
cord-021419-nypnib0h	102	10	removed	remove	VBN
cord-021419-nypnib0h	102	11	by	by	IN
cord-021419-nypnib0h	102	12	the	the	DT
cord-021419-nypnib0h	102	13	treatment	treatment	NN
cord-021419-nypnib0h	102	14	with	with	IN
cord-021419-nypnib0h	102	15	a	a	DT
cord-021419-nypnib0h	102	16	5	5	CD
cord-021419-nypnib0h	102	17	%	%	NN
cord-021419-nypnib0h	102	18	secondary	secondary	JJ
cord-021419-nypnib0h	102	19	amine	amine	NN
cord-021419-nypnib0h	102	20	solution	solution	NN
cord-021419-nypnib0h	102	21	.	.	.
cord-021419-nypnib0h	103	1	Compound	compound	NN
cord-021419-nypnib0h	103	2	8	8	CD
cord-021419-nypnib0h	103	3	exhibits	exhibit	VBZ
cord-021419-nypnib0h	103	4	high	high	JJ
cord-021419-nypnib0h	103	5	activity	activity	NN
cord-021419-nypnib0h	103	6	against	against	IN
cord-021419-nypnib0h	103	7	sensitive	sensitive	JJ
cord-021419-nypnib0h	103	8	and	and	CC
cord-021419-nypnib0h	103	9	resistant	resistant	JJ
cord-021419-nypnib0h	103	10	clinical	clinical	JJ
cord-021419-nypnib0h	103	11	strains	strain	NNS
cord-021419-nypnib0h	103	12	of	of	IN
cord-021419-nypnib0h	103	13	Gram	gram	NN
cord-021419-nypnib0h	103	14	-	-	HYPH
cord-021419-nypnib0h	103	15	positive	positive	JJ
cord-021419-nypnib0h	103	16	bacteria	bacteria	NNS
cord-021419-nypnib0h	103	17	,	,	,
cord-021419-nypnib0h	103	18	including	include	VBG
cord-021419-nypnib0h	103	19	VRE	VRE	NNP
cord-021419-nypnib0h	103	20	.	.	.
cord-021419-nypnib0h	104	1	18	18	CD
cord-021419-nypnib0h	104	2	 	 	_SP
cord-021419-nypnib0h	105	1	In	in	IN
cord-021419-nypnib0h	105	2	order	order	NN
cord-021419-nypnib0h	105	3	to	to	TO
cord-021419-nypnib0h	105	4	study	study	VB
cord-021419-nypnib0h	105	5	in	in	IN
cord-021419-nypnib0h	105	6	detail	detail	NN
cord-021419-nypnib0h	105	7	the	the	DT
cord-021419-nypnib0h	105	8	interaction	interaction	NN
cord-021419-nypnib0h	105	9	between	between	IN
cord-021419-nypnib0h	105	10	the	the	DT
cord-021419-nypnib0h	105	11	antibiotic	antibiotic	NN
cord-021419-nypnib0h	105	12	and	and	CC
cord-021419-nypnib0h	105	13	the	the	DT
cord-021419-nypnib0h	105	14	target	target	NN
cord-021419-nypnib0h	105	15	in	in	IN
cord-021419-nypnib0h	105	16	the	the	DT
cord-021419-nypnib0h	105	17	intact	intact	JJ
cord-021419-nypnib0h	105	18	bacterial	bacterial	JJ
cord-021419-nypnib0h	105	19	cell	cell	NN
cord-021419-nypnib0h	105	20	by	by	IN
cord-021419-nypnib0h	105	21	solid	solid	JJ
cord-021419-nypnib0h	105	22	-	-	HYPH
cord-021419-nypnib0h	105	23	state	state	NN
cord-021419-nypnib0h	105	24	NMR	nmr	NN
cord-021419-nypnib0h	105	25	spectroscopy	spectroscopy	NN
cord-021419-nypnib0h	105	26	using	use	VBG
cord-021419-nypnib0h	105	27	the	the	DT
cord-021419-nypnib0h	105	28	rotational	rotational	JJ
cord-021419-nypnib0h	105	29	-	-	HYPH
cord-021419-nypnib0h	105	30	echo	echo	NN
cord-021419-nypnib0h	105	31	double	double	JJ
cord-021419-nypnib0h	105	32	resonance	resonance	NN
cord-021419-nypnib0h	105	33	(	(	-LRB-
cord-021419-nypnib0h	105	34	REDOR	REDOR	NNP
cord-021419-nypnib0h	105	35	)	)	-RRB-
cord-021419-nypnib0h	105	36	technique	technique	NN
cord-021419-nypnib0h	105	37	,	,	,
cord-021419-nypnib0h	105	38	15	15	CD
cord-021419-nypnib0h	105	39	NH	NH	NNP
cord-021419-nypnib0h	105	40	2	2	CD
cord-021419-nypnib0h	105	41	-or	-or	.
cord-021419-nypnib0h	106	1	F	F	NNP
cord-021419-nypnib0h	106	2	-	-	HYPH
cord-021419-nypnib0h	106	3	labelled	label	VBN
cord-021419-nypnib0h	106	4	substituents	substituent	NNS
cord-021419-nypnib0h	106	5	were	be	VBD
cord-021419-nypnib0h	106	6	introduced	introduce	VBN
cord-021419-nypnib0h	106	7	into	into	IN
cord-021419-nypnib0h	106	8	amino	amino	NN
cord-021419-nypnib0h	106	9	acid	acid	NN
cord-021419-nypnib0h	106	10	residues	residue	NNS
cord-021419-nypnib0h	106	11	3	3	CD
cord-021419-nypnib0h	107	1	(	(	-LRB-
cord-021419-nypnib0h	107	2	AA3	AA3	NNP
cord-021419-nypnib0h	107	3	)	)	-RRB-
cord-021419-nypnib0h	107	4	and(or	and(or	NNP
cord-021419-nypnib0h	107	5	)	)	-RRB-
cord-021419-nypnib0h	107	6	7	7	CD
cord-021419-nypnib0h	108	1	(	(	-LRB-
cord-021419-nypnib0h	108	2	AA7	aa7	JJ
cord-021419-nypnib0h	108	3	)	)	-RRB-
cord-021419-nypnib0h	108	4	of	of	IN
cord-021419-nypnib0h	108	5	the	the	DT
cord-021419-nypnib0h	108	6	peptide	peptide	NN
cord-021419-nypnib0h	108	7	chain	chain	NN
cord-021419-nypnib0h	108	8	of	of	IN
cord-021419-nypnib0h	108	9	the	the	DT
cord-021419-nypnib0h	108	10	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	108	11	eremomycin	eremomycin	NNS
cord-021419-nypnib0h	108	12	(	(	-LRB-
cord-021419-nypnib0h	108	13	3	3	CD
cord-021419-nypnib0h	108	14	)	)	-RRB-
cord-021419-nypnib0h	108	15	.	.	.
cord-021419-nypnib0h	109	1	19	19	CD
cord-021419-nypnib0h	110	1	The	the	DT
cord-021419-nypnib0h	110	2	15	15	CD
cord-021419-nypnib0h	110	3	N	n	CD
cord-021419-nypnib0h	110	4	label	label	NN
cord-021419-nypnib0h	110	5	was	be	VBD
cord-021419-nypnib0h	110	6	introduced	introduce	VBN
cord-021419-nypnib0h	110	7	in	in	IN
cord-021419-nypnib0h	110	8	the	the	DT
cord-021419-nypnib0h	110	9	vicinity	vicinity	NN
cord-021419-nypnib0h	110	10	of	of	IN
cord-021419-nypnib0h	110	11	the	the	DT
cord-021419-nypnib0h	110	12	binding	bind	VBG
cord-021419-nypnib0h	110	13	pocket	pocket	NN
cord-021419-nypnib0h	110	14	of	of	IN
cord-021419-nypnib0h	110	15	the	the	DT
cord-021419-nypnib0h	110	16	antibiotic	antibiotic	NN
cord-021419-nypnib0h	110	17	.	.	.
cord-021419-nypnib0h	111	1	This	this	DT
cord-021419-nypnib0h	111	2	was	be	VBD
cord-021419-nypnib0h	111	3	accomplished	accomplish	VBN
cord-021419-nypnib0h	111	4	using	use	VBG
cord-021419-nypnib0h	111	5	carboxyeremomycin	carboxyeremomycin	NNS
cord-021419-nypnib0h	111	6	(	(	-LRB-
cord-021419-nypnib0h	111	7	9	9	CD
cord-021419-nypnib0h	111	8	)	)	-RRB-
cord-021419-nypnib0h	111	9	,	,	,
cord-021419-nypnib0h	111	10	which	which	WDT
cord-021419-nypnib0h	111	11	was	be	VBD
cord-021419-nypnib0h	111	12	synthesized	synthesize	VBN
cord-021419-nypnib0h	111	13	previously	previously	RB
cord-021419-nypnib0h	111	14	by	by	IN
cord-021419-nypnib0h	111	15	the	the	DT
cord-021419-nypnib0h	111	16	selective	selective	JJ
cord-021419-nypnib0h	111	17	alkaline	alkaline	JJ
cord-021419-nypnib0h	111	18	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	111	19	of	of	IN
cord-021419-nypnib0h	111	20	compound	compound	NN
cord-021419-nypnib0h	111	21	3	3	CD
cord-021419-nypnib0h	111	22	in	in	IN
cord-021419-nypnib0h	111	23	a	a	DT
cord-021419-nypnib0h	111	24	saturated	saturated	JJ
cord-021419-nypnib0h	111	25	aqueous	aqueous	JJ
cord-021419-nypnib0h	111	26	solution	solution	NN
cord-021419-nypnib0h	111	27	of	of	IN
cord-021419-nypnib0h	111	28	Ba(OH	Ba(OH	NNP
cord-021419-nypnib0h	111	29	)	)	-RRB-
cord-021419-nypnib0h	111	30	2	2	CD
cord-021419-nypnib0h	111	31	.	.	.
cord-021419-nypnib0h	112	1	Under	under	IN
cord-021419-nypnib0h	112	2	these	these	DT
cord-021419-nypnib0h	112	3	conditions	condition	NNS
cord-021419-nypnib0h	112	4	,	,	,
cord-021419-nypnib0h	112	5	vancomycin	vancomycin	FW
cord-021419-nypnib0h	112	6	(	(	-LRB-
cord-021419-nypnib0h	112	7	1	1	CD
cord-021419-nypnib0h	112	8	)	)	-RRB-
cord-021419-nypnib0h	112	9	decomposes	decompose	VBZ
cord-021419-nypnib0h	112	10	.	.	.
cord-021419-nypnib0h	113	1	Carboxyeremomycin	Carboxyeremomycin	NNP
cord-021419-nypnib0h	113	2	[	[	-LRB-
cord-021419-nypnib0h	113	3	15	15	CD
cord-021419-nypnib0h	113	4	N]-bisamide	N]-bisamide	NNP
cord-021419-nypnib0h	113	5	10	10	CD
cord-021419-nypnib0h	113	6	was	be	VBD
cord-021419-nypnib0h	113	7	synthesized	synthesize	VBN
cord-021419-nypnib0h	113	8	by	by	IN
cord-021419-nypnib0h	113	9	the	the	DT
cord-021419-nypnib0h	113	10	reaction	reaction	NN
cord-021419-nypnib0h	113	11	of	of	IN
cord-021419-nypnib0h	113	12	compound	compound	NN
cord-021419-nypnib0h	113	13	9	9	CD
cord-021419-nypnib0h	113	14	with	with	IN
cord-021419-nypnib0h	113	15	appropriate	appropriate	JJ
cord-021419-nypnib0h	113	16	amines	amine	NNS
cord-021419-nypnib0h	113	17	in	in	IN
cord-021419-nypnib0h	113	18	the	the	DT
cord-021419-nypnib0h	113	19	presence	presence	NN
cord-021419-nypnib0h	113	20	of	of	IN
cord-021419-nypnib0h	113	21	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	114	1	(	(	-LRB-
cord-021419-nypnib0h	114	2	Scheme	scheme	NN
cord-021419-nypnib0h	114	3	3	3	CD
cord-021419-nypnib0h	114	4	,	,	,
cord-021419-nypnib0h	114	5	Fig	Fig	NNP
cord-021419-nypnib0h	114	6	.	.	NNP
cord-021419-nypnib0h	114	7	1	1	CD
cord-021419-nypnib0h	114	8	a3,c3	a3,c3	CD
cord-021419-nypnib0h	114	9	)	)	-RRB-
cord-021419-nypnib0h	114	10	.	.	.
cord-021419-nypnib0h	115	1	19	19	CD
cord-021419-nypnib0h	116	1	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	116	2	4-fluorophenyl	4-fluorophenyl	CD
cord-021419-nypnib0h	116	3	-	-	HYPH
cord-021419-nypnib0h	116	4	N	n	NN
cord-021419-nypnib0h	116	5	-	-	HYPH
cord-021419-nypnib0h	116	6	piperazide	piperazide	NNP
cord-021419-nypnib0h	116	7	(	(	-LRB-
cord-021419-nypnib0h	116	8	11	11	CD
cord-021419-nypnib0h	116	9	)	)	-RRB-
cord-021419-nypnib0h	116	10	was	be	VBD
cord-021419-nypnib0h	116	11	synthesized	synthesize	VBN
cord-021419-nypnib0h	116	12	by	by	IN
cord-021419-nypnib0h	116	13	the	the	DT
cord-021419-nypnib0h	116	14	conventional	conventional	JJ
cord-021419-nypnib0h	116	15	amidation	amidation	NN
cord-021419-nypnib0h	116	16	method	method	NN
cord-021419-nypnib0h	116	17	in	in	IN
cord-021419-nypnib0h	116	18	the	the	DT
cord-021419-nypnib0h	116	19	presence	presence	NN
cord-021419-nypnib0h	116	20	of	of	IN
cord-021419-nypnib0h	116	21	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	116	22	.	.	.
cord-021419-nypnib0h	117	1	The	the	DT
cord-021419-nypnib0h	117	2	REDOR	REDOR	NNP
cord-021419-nypnib0h	117	3	experiments	experiment	NNS
cord-021419-nypnib0h	117	4	were	be	VBD
cord-021419-nypnib0h	117	5	performed	perform	VBN
cord-021419-nypnib0h	117	6	using	use	VBG
cord-021419-nypnib0h	117	7	intact	intact	JJ
cord-021419-nypnib0h	117	8	Staphylococcus	Staphylococcus	NNP
cord-021419-nypnib0h	117	9	aureus	aureus	NN
cord-021419-nypnib0h	117	10	cells	cell	NNS
cord-021419-nypnib0h	117	11	,	,	,
cord-021419-nypnib0h	117	12	which	which	WDT
cord-021419-nypnib0h	117	13	were	be	VBD
cord-021419-nypnib0h	117	14	grown	grow	VBN
cord-021419-nypnib0h	117	15	in	in	IN
cord-021419-nypnib0h	117	16	a	a	DT
cord-021419-nypnib0h	117	17	culture	culture	NN
cord-021419-nypnib0h	117	18	medium	medium	NN
cord-021419-nypnib0h	117	19	containing	contain	VBG
cord-021419-nypnib0h	117	20	bioprecursors	bioprecursor	NNS
cord-021419-nypnib0h	117	21	with	with	IN
cord-021419-nypnib0h	117	22	isotope	isotope	NN
cord-021419-nypnib0h	117	23	-	-	HYPH
cord-021419-nypnib0h	117	24	labelled	label	VBN
cord-021419-nypnib0h	117	25	atoms	atom	NNS
cord-021419-nypnib0h	117	26	(	(	-LRB-
cord-021419-nypnib0h	117	27	e.g.	e.g.	RB
cord-021419-nypnib0h	117	28	,	,	,
cord-021419-nypnib0h	117	29	13	13	CD
cord-021419-nypnib0h	117	30	C	c	NN
cord-021419-nypnib0h	117	31	-	-	HYPH
cord-021419-nypnib0h	117	32	amino	amino	NN
cord-021419-nypnib0h	117	33	acid	acid	NN
cord-021419-nypnib0h	117	34	)	)	-RRB-
cord-021419-nypnib0h	117	35	.	.	.
cord-021419-nypnib0h	118	1	The	the	DT
cord-021419-nypnib0h	118	2	15	15	CD
cord-021419-nypnib0h	118	3	N	n	CD
cord-021419-nypnib0h	118	4	-	-	:
cord-021419-nypnib0h	118	5	or	or	CC
cord-021419-nypnib0h	118	6	F	F	NNP
cord-021419-nypnib0h	118	7	-	-	HYPH
cord-021419-nypnib0h	118	8	containing	contain	VBG
cord-021419-nypnib0h	118	9	antibiotic	antibiotic	NN
cord-021419-nypnib0h	118	10	that	that	WDT
cord-021419-nypnib0h	118	11	was	be	VBD
cord-021419-nypnib0h	118	12	added	add	VBN
cord-021419-nypnib0h	118	13	to	to	IN
cord-021419-nypnib0h	118	14	the	the	DT
cord-021419-nypnib0h	118	15	medium	medium	NN
cord-021419-nypnib0h	118	16	inhibits	inhibit	VBZ
cord-021419-nypnib0h	118	17	bacterial	bacterial	JJ
cord-021419-nypnib0h	118	18	growth	growth	NN
cord-021419-nypnib0h	118	19	by	by	IN
cord-021419-nypnib0h	118	20	forming	form	VBG
cord-021419-nypnib0h	118	21	a	a	DT
cord-021419-nypnib0h	118	22	stable	stable	JJ
cord-021419-nypnib0h	118	23	complex	complex	NN
cord-021419-nypnib0h	118	24	with	with	IN
cord-021419-nypnib0h	118	25	13	13	CD
cord-021419-nypnib0h	118	26	C	c	NN
cord-021419-nypnib0h	118	27	-	-	HYPH
cord-021419-nypnib0h	118	28	labelled	label	VBN
cord-021419-nypnib0h	118	29	peptidoglycan	peptidoglycan	NN
cord-021419-nypnib0h	118	30	moieties	moiety	NNS
cord-021419-nypnib0h	118	31	(	(	-LRB-
cord-021419-nypnib0h	118	32	see	see	VB
cord-021419-nypnib0h	118	33	Fig	Fig	NNP
cord-021419-nypnib0h	118	34	.	.	NNP
cord-021419-nypnib0h	118	35	2	2	CD
cord-021419-nypnib0h	118	36	,	,	,
cord-021419-nypnib0h	118	37	hydrogen	hydrogen	NN
cord-021419-nypnib0h	118	38	bonds	bond	NNS
cord-021419-nypnib0h	118	39	are	be	VBP
cord-021419-nypnib0h	118	40	indicated	indicate	VBN
cord-021419-nypnib0h	118	41	by	by	IN
cord-021419-nypnib0h	118	42	dashed	dash	VBN
cord-021419-nypnib0h	118	43	lines	line	NNS
cord-021419-nypnib0h	118	44	)	)	-RRB-
cord-021419-nypnib0h	118	45	.	.	.
cord-021419-nypnib0h	119	1	19	19	CD
cord-021419-nypnib0h	119	2	,	,	,
cord-021419-nypnib0h	119	3	20	20	CD
cord-021419-nypnib0h	120	1	The	the	DT
cord-021419-nypnib0h	120	2	study	study	NN
cord-021419-nypnib0h	120	3	of	of	IN
cord-021419-nypnib0h	120	4	the	the	DT
cord-021419-nypnib0h	120	5	complex	complex	NN
cord-021419-nypnib0h	120	6	with	with	IN
cord-021419-nypnib0h	120	7	compound	compound	NN
cord-021419-nypnib0h	120	8	10	10	CD
cord-021419-nypnib0h	120	9	provides	provide	VBZ
cord-021419-nypnib0h	120	10	an	an	DT
cord-021419-nypnib0h	120	11	estimate	estimate	NN
cord-021419-nypnib0h	120	12	of	of	IN
cord-021419-nypnib0h	120	13	the	the	DT
cord-021419-nypnib0h	120	14	distance	distance	NN
cord-021419-nypnib0h	120	15	from	from	IN
cord-021419-nypnib0h	120	16	The	the	DT
cord-021419-nypnib0h	120	17	distance	distance	NN
cord-021419-nypnib0h	120	18	between	between	IN
cord-021419-nypnib0h	120	19	the	the	DT
cord-021419-nypnib0h	120	20	C	c	NN
cord-021419-nypnib0h	120	21	-	-	HYPH
cord-021419-nypnib0h	120	22	terminal	terminal	NN
cord-021419-nypnib0h	120	23	[	[	-LRB-
cord-021419-nypnib0h	120	24	15	15	CD
cord-021419-nypnib0h	120	25	N]-amide	n]-amide	CD
cord-021419-nypnib0h	120	26	of	of	IN
cord-021419-nypnib0h	120	27	eremomycin	eremomycin	NNS
cord-021419-nypnib0h	120	28	(	(	-LRB-
cord-021419-nypnib0h	120	29	10	10	CD
cord-021419-nypnib0h	120	30	)	)	-RRB-
cord-021419-nypnib0h	120	31	and	and	CC
cord-021419-nypnib0h	120	32	L-	L-	NNPS
cord-021419-nypnib0h	121	1	[	[	-LRB-
cord-021419-nypnib0h	121	2	13	13	CD
cord-021419-nypnib0h	121	3	C(3)]Ala	C(3)]Ala	NNP
cord-021419-nypnib0h	121	4	1	1	CD
cord-021419-nypnib0h	121	5	of	of	IN
cord-021419-nypnib0h	121	6	the	the	DT
cord-021419-nypnib0h	121	7	peptidoglycan	peptidoglycan	NN
cord-021419-nypnib0h	121	8	stem	stem	NN
cord-021419-nypnib0h	121	9	is	be	VBZ
cord-021419-nypnib0h	121	10	3.5	3.5	CD
cord-021419-nypnib0h	121	11	#	#	NN
cord-021419-nypnib0h	121	12	A	a	NN
cord-021419-nypnib0h	121	13	(	(	-LRB-
cord-021419-nypnib0h	121	14	see	see	VB
cord-021419-nypnib0h	121	15	Fig	Fig	NNP
cord-021419-nypnib0h	121	16	.	.	NNP
cord-021419-nypnib0h	121	17	2	2	CD
cord-021419-nypnib0h	121	18	,	,	,
cord-021419-nypnib0h	121	19	a	a	DT
cord-021419-nypnib0h	121	20	solid	solid	JJ
cord-021419-nypnib0h	121	21	arrow	arrow	NN
cord-021419-nypnib0h	121	22	)	)	-RRB-
cord-021419-nypnib0h	121	23	.	.	.
cord-021419-nypnib0h	122	1	20	20	CD
cord-021419-nypnib0h	122	2	Consequently	consequently	RB
cord-021419-nypnib0h	122	3	,	,	,
cord-021419-nypnib0h	122	4	higher	high	JJR
cord-021419-nypnib0h	122	5	activity	activity	NN
cord-021419-nypnib0h	122	6	of	of	IN
cord-021419-nypnib0h	122	7	eremomycin	eremomycin	JJ
cord-021419-nypnib0h	122	8	amide	amide	NN
cord-021419-nypnib0h	122	9	10	10	CD
cord-021419-nypnib0h	122	10	(	(	-LRB-
cord-021419-nypnib0h	122	11	compared	compare	VBN
cord-021419-nypnib0h	122	12	to	to	IN
cord-021419-nypnib0h	122	13	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	122	14	1	1	CD
cord-021419-nypnib0h	122	15	or	or	CC
cord-021419-nypnib0h	122	16	3	3	CD
cord-021419-nypnib0h	122	17	)	)	-RRB-
cord-021419-nypnib0h	122	18	against	against	IN
cord-021419-nypnib0h	122	19	resistant	resistant	JJ
cord-021419-nypnib0h	122	20	VISA	VISA	NNP
cord-021419-nypnib0h	122	21	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	122	22	can	can	MD
cord-021419-nypnib0h	122	23	be	be	VB
cord-021419-nypnib0h	122	24	attributed	attribute	VBN
cord-021419-nypnib0h	122	25	to	to	IN
cord-021419-nypnib0h	122	26	the	the	DT
cord-021419-nypnib0h	122	27	fact	fact	NN
cord-021419-nypnib0h	122	28	that	that	IN
cord-021419-nypnib0h	122	29	this	this	DT
cord-021419-nypnib0h	122	30	compound	compound	NN
cord-021419-nypnib0h	122	31	interacts	interact	VBZ
cord-021419-nypnib0h	122	32	with	with	IN
cord-021419-nypnib0h	122	33	the	the	DT
cord-021419-nypnib0h	122	34	peptidoglycan	peptidoglycan	NN
cord-021419-nypnib0h	122	35	not	not	RB
cord-021419-nypnib0h	122	36	only	only	RB
cord-021419-nypnib0h	122	37	via	via	IN
cord-021419-nypnib0h	122	38	a	a	DT
cord-021419-nypnib0h	122	39	classical	classical	JJ
cord-021419-nypnib0h	122	40	model	model	NN
cord-021419-nypnib0h	122	41	(	(	-LRB-
cord-021419-nypnib0h	122	42	i.e.	i.e.	FW
cord-021419-nypnib0h	122	43	,	,	,
cord-021419-nypnib0h	122	44	with	with	IN
cord-021419-nypnib0h	122	45	the	the	DT
cord-021419-nypnib0h	122	46	D	D	NNP
cord-021419-nypnib0h	122	47	-	-	HYPH
cord-021419-nypnib0h	122	48	Ala	ala	NN
cord-021419-nypnib0h	122	49	-	-	HYPH
cord-021419-nypnib0h	122	50	D	D	NNP
cord-021419-nypnib0h	122	51	-	-	HYPH
cord-021419-nypnib0h	122	52	Ala	Ala	NNP
cord-021419-nypnib0h	122	53	target	target	NN
cord-021419-nypnib0h	122	54	)	)	-RRB-
cord-021419-nypnib0h	122	55	but	but	CC
cord-021419-nypnib0h	122	56	also	also	RB
cord-021419-nypnib0h	122	57	with	with	IN
cord-021419-nypnib0h	122	58	the	the	DT
cord-021419-nypnib0h	122	59	L-	L-	NNPS
cord-021419-nypnib0h	122	60	[	[	-LRB-
cord-021419-nypnib0h	122	61	13	13	CD
cord-021419-nypnib0h	122	62	C(3)]Ala	C(3)]Ala	NNP
cord-021419-nypnib0h	122	63	group	group	NN
cord-021419-nypnib0h	122	64	of	of	IN
cord-021419-nypnib0h	122	65	its	-PRON-	PRP$
cord-021419-nypnib0h	122	66	stem	stem	NN
cord-021419-nypnib0h	122	67	.	.	.
cord-021419-nypnib0h	123	1	Besides	besides	RB
cord-021419-nypnib0h	123	2	,	,	,
cord-021419-nypnib0h	123	3	there	there	EX
cord-021419-nypnib0h	123	4	is	be	VBZ
cord-021419-nypnib0h	123	5	an	an	DT
cord-021419-nypnib0h	123	6	additional	additional	JJ
cord-021419-nypnib0h	123	7	binding	binding	NN
cord-021419-nypnib0h	123	8	site	site	NN
cord-021419-nypnib0h	123	9	of	of	IN
cord-021419-nypnib0h	123	10	derivative	derivative	JJ
cord-021419-nypnib0h	123	11	11	11	CD
cord-021419-nypnib0h	123	12	to	to	IN
cord-021419-nypnib0h	123	13	the	the	DT
cord-021419-nypnib0h	123	14	target	target	NN
cord-021419-nypnib0h	123	15	,	,	,
cord-021419-nypnib0h	123	16	which	which	WDT
cord-021419-nypnib0h	123	17	can	can	MD
cord-021419-nypnib0h	123	18	also	also	RB
cord-021419-nypnib0h	123	19	account	account	VB
cord-021419-nypnib0h	123	20	for	for	IN
cord-021419-nypnib0h	123	21	its	-PRON-	PRP$
cord-021419-nypnib0h	123	22	high	high	JJ
cord-021419-nypnib0h	123	23	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	123	24	activity	activity	NN
cord-021419-nypnib0h	123	25	against	against	IN
cord-021419-nypnib0h	123	26	VRE	VRE	NNP
cord-021419-nypnib0h	123	27	and	and	CC
cord-021419-nypnib0h	123	28	VISA	VISA	NNP
cord-021419-nypnib0h	123	29	.	.	.
cord-021419-nypnib0h	124	1	21	21	CD
cord-021419-nypnib0h	124	2	 	 	_SP
cord-021419-nypnib0h	125	1	Previously	previously	RB
cord-021419-nypnib0h	125	2	,	,	,
cord-021419-nypnib0h	125	3	it	-PRON-	PRP
cord-021419-nypnib0h	125	4	was	be	VBD
cord-021419-nypnib0h	125	5	shown	show	VBN
cord-021419-nypnib0h	125	6	that	that	IN
cord-021419-nypnib0h	125	7	the	the	DT
cord-021419-nypnib0h	125	8	elimination	elimination	NN
cord-021419-nypnib0h	125	9	of	of	IN
cord-021419-nypnib0h	125	10	sugars	sugar	NNS
cord-021419-nypnib0h	125	11	(	(	-LRB-
cord-021419-nypnib0h	125	12	see	see	VB
cord-021419-nypnib0h	125	13	Fig	Fig	NNP
cord-021419-nypnib0h	125	14	.	.	.
cord-021419-nypnib0h	125	15	1	1	CD
cord-021419-nypnib0h	125	16	d	d	NN
cord-021419-nypnib0h	125	17	)	)	-RRB-
cord-021419-nypnib0h	125	18	and	and	CC
cord-021419-nypnib0h	125	19	the	the	DT
cord-021419-nypnib0h	125	20	introduction	introduction	NN
cord-021419-nypnib0h	125	21	of	of	IN
cord-021419-nypnib0h	125	22	a	a	DT
cord-021419-nypnib0h	125	23	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	125	24	residue	residue	NN
cord-021419-nypnib0h	125	25	into	into	IN
cord-021419-nypnib0h	125	26	the	the	DT
cord-021419-nypnib0h	125	27	aglycone	aglycone	NN
cord-021419-nypnib0h	125	28	can	can	MD
cord-021419-nypnib0h	125	29	give	give	VB
cord-021419-nypnib0h	125	30	rise	rise	NN
cord-021419-nypnib0h	125	31	to	to	IN
cord-021419-nypnib0h	125	32	aglycone	aglycone	JJ
cord-021419-nypnib0h	125	33	derivatives	derivative	NNS
cord-021419-nypnib0h	125	34	of	of	IN
cord-021419-nypnib0h	125	35	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	125	36	exhibiting	exhibit	VBG
cord-021419-nypnib0h	125	37	activity	activity	NN
cord-021419-nypnib0h	125	38	against	against	IN
cord-021419-nypnib0h	125	39	different	different	JJ
cord-021419-nypnib0h	125	40	types	type	NNS
cord-021419-nypnib0h	125	41	of	of	IN
cord-021419-nypnib0h	125	42	enveloped	envelop	VBN
cord-021419-nypnib0h	125	43	viruses	virus	NNS
cord-021419-nypnib0h	125	44	.	.	.
cord-021419-nypnib0h	126	1	22	22	CD
cord-021419-nypnib0h	127	1	The	the	DT
cord-021419-nypnib0h	127	2	modification	modification	NN
cord-021419-nypnib0h	127	3	of	of	IN
cord-021419-nypnib0h	127	4	the	the	DT
cord-021419-nypnib0h	127	5	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	127	6	aglycone	aglycone	NNP
cord-021419-nypnib0h	127	7	(	(	-LRB-
cord-021419-nypnib0h	127	8	12a	12a	NNS
cord-021419-nypnib0h	127	9	)	)	-RRB-
cord-021419-nypnib0h	127	10	,	,	,
cord-021419-nypnib0h	127	11	its	-PRON-	PRP$
cord-021419-nypnib0h	127	12	de	de	JJ
cord-021419-nypnib0h	127	13	-	-	HYPH
cord-021419-nypnib0h	127	14	D	D	NNP
cord-021419-nypnib0h	127	15	-	-	HYPH
cord-021419-nypnib0h	127	16	MeLeu	MeLeu	NNP
cord-021419-nypnib0h	127	17	analogues	analogue	NNS
cord-021419-nypnib0h	127	18	(	(	-LRB-
cord-021419-nypnib0h	127	19	hexapeptide	hexapeptide	NN
cord-021419-nypnib0h	127	20	,	,	,
cord-021419-nypnib0h	127	21	13a	13a	NNS
cord-021419-nypnib0h	127	22	)	)	-RRB-
cord-021419-nypnib0h	127	23	,	,	,
cord-021419-nypnib0h	127	24	which	which	WDT
cord-021419-nypnib0h	127	25	was	be	VBD
cord-021419-nypnib0h	127	26	produced	produce	VBN
cord-021419-nypnib0h	127	27	by	by	IN
cord-021419-nypnib0h	127	28	the	the	DT
cord-021419-nypnib0h	127	29	cleavage	cleavage	NN
cord-021419-nypnib0h	127	30	of	of	IN
cord-021419-nypnib0h	127	31	amino	amino	NN
cord-021419-nypnib0h	127	32	acid	acid	NN
cord-021419-nypnib0h	127	33	1	1	CD
cord-021419-nypnib0h	127	34	(	(	-LRB-
cord-021419-nypnib0h	127	35	AA1	AA1	NNP
cord-021419-nypnib0h	127	36	)	)	-RRB-
cord-021419-nypnib0h	127	37	using	use	VBG
cord-021419-nypnib0h	127	38	the	the	DT
cord-021419-nypnib0h	127	39	Edman	Edman	NNP
cord-021419-nypnib0h	127	40	method	method	NN
cord-021419-nypnib0h	127	41	(	(	-LRB-
cord-021419-nypnib0h	127	42	see	see	VB
cord-021419-nypnib0h	127	43	Fig	Fig	NNP
cord-021419-nypnib0h	127	44	.	.	.
cord-021419-nypnib0h	127	45	1	1	CD
cord-021419-nypnib0h	127	46	e	e	NN
cord-021419-nypnib0h	127	47	)	)	-RRB-
cord-021419-nypnib0h	127	48	,	,	,
cord-021419-nypnib0h	127	49	and	and	CC
cord-021419-nypnib0h	127	50	the	the	DT
cord-021419-nypnib0h	127	51	teicoplanin	teicoplanin	JJ
cord-021419-nypnib0h	127	52	aglycone	aglycone	NNP
cord-021419-nypnib0h	127	53	(	(	-LRB-
cord-021419-nypnib0h	127	54	14	14	CD
cord-021419-nypnib0h	127	55	)	)	-RRB-
cord-021419-nypnib0h	127	56	gave	give	VBD
cord-021419-nypnib0h	127	57	a	a	DT
cord-021419-nypnib0h	127	58	series	series	NN
cord-021419-nypnib0h	127	59	of	of	IN
cord-021419-nypnib0h	127	60	new	new	JJ
cord-021419-nypnib0h	127	61	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	127	62	derivatives	derivative	NNS
cord-021419-nypnib0h	127	63	.	.	.
cord-021419-nypnib0h	128	1	(	(	-LRB-
cord-021419-nypnib0h	128	2	1-Adamantylmethyl)amide	1-adamantylmethyl)amide	CD
cord-021419-nypnib0h	128	3	of	of	IN
cord-021419-nypnib0h	128	4	the	the	DT
cord-021419-nypnib0h	128	5	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	128	6	aglycone	aglycone	NNP
cord-021419-nypnib0h	128	7	(	(	-LRB-
cord-021419-nypnib0h	128	8	12b	12b	CD
cord-021419-nypnib0h	128	9	)	)	-RRB-
cord-021419-nypnib0h	128	10	and	and	CC
cord-021419-nypnib0h	128	11	its	-PRON-	PRP$
cord-021419-nypnib0h	128	12	hexapeptide	hexapeptide	NN
cord-021419-nypnib0h	128	13	analogue	analogue	NN
cord-021419-nypnib0h	128	14	(	(	-LRB-
cord-021419-nypnib0h	128	15	13b	13b	NNS
cord-021419-nypnib0h	128	16	)	)	-RRB-
cord-021419-nypnib0h	128	17	are	be	VBP
cord-021419-nypnib0h	128	18	derived	derive	VBN
cord-021419-nypnib0h	128	19	by	by	IN
cord-021419-nypnib0h	128	20	the	the	DT
cord-021419-nypnib0h	128	21	reaction	reaction	NN
cord-021419-nypnib0h	128	22	of	of	IN
cord-021419-nypnib0h	128	23	1-adamantylmethylamine	1-adamantylmethylamine	CD
cord-021419-nypnib0h	128	24	with	with	IN
cord-021419-nypnib0h	128	25	12a	12a	NNS
cord-021419-nypnib0h	128	26	or	or	CC
cord-021419-nypnib0h	128	27	13a	13a	NNS
cord-021419-nypnib0h	128	28	in	in	IN
cord-021419-nypnib0h	128	29	the	the	DT
cord-021419-nypnib0h	128	30	presence	presence	NN
cord-021419-nypnib0h	128	31	of	of	IN
cord-021419-nypnib0h	128	32	diphenylphosphoryl	diphenylphosphoryl	NNP
cord-021419-nypnib0h	128	33	azide	azide	NNP
cord-021419-nypnib0h	128	34	(	(	-LRB-
cord-021419-nypnib0h	128	35	DPPA	DPPA	NNP
cord-021419-nypnib0h	128	36	)	)	-RRB-
cord-021419-nypnib0h	128	37	(	(	-LRB-
cord-021419-nypnib0h	128	38	Scheme	scheme	NN
cord-021419-nypnib0h	128	39	4	4	CD
cord-021419-nypnib0h	128	40	)	)	-RRB-
cord-021419-nypnib0h	128	41	.	.	.
cord-021419-nypnib0h	129	1	Diphenylphosphoryl	Diphenylphosphoryl	NNP
cord-021419-nypnib0h	129	2	azide	azide	NN
cord-021419-nypnib0h	129	3	rather	rather	RB
cord-021419-nypnib0h	129	4	than	than	IN
cord-021419-nypnib0h	129	5	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	129	6	is	be	VBZ
cord-021419-nypnib0h	129	7	the	the	DT
cord-021419-nypnib0h	129	8	reagent	reagent	NN
cord-021419-nypnib0h	129	9	of	of	IN
cord-021419-nypnib0h	129	10	choice	choice	NN
cord-021419-nypnib0h	129	11	for	for	IN
cord-021419-nypnib0h	129	12	the	the	DT
cord-021419-nypnib0h	129	13	amidation	amidation	NN
cord-021419-nypnib0h	129	14	of	of	IN
cord-021419-nypnib0h	129	15	aglycones	aglycones	NNP
cord-021419-nypnib0h	129	16	,	,	,
cord-021419-nypnib0h	129	17	because	because	IN
cord-021419-nypnib0h	129	18	the	the	DT
cord-021419-nypnib0h	129	19	reactions	reaction	NNS
cord-021419-nypnib0h	129	20	in	in	IN
cord-021419-nypnib0h	129	21	the	the	DT
cord-021419-nypnib0h	129	22	presence	presence	NN
cord-021419-nypnib0h	129	23	of	of	IN
cord-021419-nypnib0h	129	24	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	129	25	often	often	RB
cord-021419-nypnib0h	129	26	afford	afford	VBP
cord-021419-nypnib0h	129	27	by	by	IN
cord-021419-nypnib0h	129	28	-	-	HYPH
cord-021419-nypnib0h	129	29	products	product	NNS
cord-021419-nypnib0h	129	30	containing	contain	VBG
cord-021419-nypnib0h	129	31	the	the	DT
cord-021419-nypnib0h	129	32	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	129	33	moiety	moiety	NN
cord-021419-nypnib0h	129	34	in	in	IN
cord-021419-nypnib0h	129	35	the	the	DT
cord-021419-nypnib0h	129	36	phenol	phenol	NN
cord-021419-nypnib0h	129	37	group	group	NN
cord-021419-nypnib0h	129	38	of	of	IN
cord-021419-nypnib0h	129	39	the	the	DT
cord-021419-nypnib0h	129	40	aglycone	aglycone	NN
cord-021419-nypnib0h	129	41	at	at	IN
cord-021419-nypnib0h	129	42	AA4	AA4	NNP
cord-021419-nypnib0h	129	43	.	.	.
cord-021419-nypnib0h	130	1	23	23	CD
cord-021419-nypnib0h	131	1	The	the	DT
cord-021419-nypnib0h	131	2	acylation	acylation	NN
cord-021419-nypnib0h	131	3	of	of	IN
cord-021419-nypnib0h	131	4	compound	compound	NN
cord-021419-nypnib0h	131	5	14	14	CD
cord-021419-nypnib0h	131	6	with	with	IN
cord-021419-nypnib0h	131	7	di	di	NNP
cord-021419-nypnib0h	131	8	-	-	HYPH
cord-021419-nypnib0h	131	9	tert	tert	JJ
cord-021419-nypnib0h	131	10	-	-	HYPH
cord-021419-nypnib0h	131	11	butyl	butyl	NNP
cord-021419-nypnib0h	131	12	dicarbonate	dicarbonate	NN
cord-021419-nypnib0h	132	1	(	(	-LRB-
cord-021419-nypnib0h	132	2	Boc	Boc	NNP
cord-021419-nypnib0h	132	3	2	2	CD
cord-021419-nypnib0h	132	4	O	O	NNP
cord-021419-nypnib0h	132	5	)	)	-RRB-
cord-021419-nypnib0h	133	1	followed	follow	VBN
cord-021419-nypnib0h	133	2	by	by	IN
cord-021419-nypnib0h	133	3	amidation	amidation	NN
cord-021419-nypnib0h	133	4	under	under	IN
cord-021419-nypnib0h	133	5	standard	standard	JJ
cord-021419-nypnib0h	133	6	conditions	condition	NNS
cord-021419-nypnib0h	133	7	in	in	IN
cord-021419-nypnib0h	133	8	the	the	DT
cord-021419-nypnib0h	133	9	presence	presence	NN
cord-021419-nypnib0h	133	10	of	of	IN
cord-021419-nypnib0h	133	11	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	133	12	gives	give	VBZ
cord-021419-nypnib0h	133	13	the	the	DT
cord-021419-nypnib0h	133	14	disubstituted	disubstituted	JJ
cord-021419-nypnib0h	133	15	derivative	derivative	JJ
cord-021419-nypnib0h	133	16	Ð	ð	NN
cord-021419-nypnib0h	133	17	(	(	-LRB-
cord-021419-nypnib0h	133	18	2-adamantyl)amide	2-adamantyl)amide	CD
cord-021419-nypnib0h	133	19	of	of	IN
cord-021419-nypnib0h	133	20	the	the	DT
cord-021419-nypnib0h	133	21	N	N	NNP
cord-021419-nypnib0h	133	22	-	-	HYPH
cord-021419-nypnib0h	133	23	Boc	Boc	NNP
cord-021419-nypnib0h	133	24	-	-	HYPH
cord-021419-nypnib0h	133	25	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	133	26	aglycone	aglycone	NNP
cord-021419-nypnib0h	133	27	(	(	-LRB-
cord-021419-nypnib0h	133	28	15	15	CD
cord-021419-nypnib0h	133	29	)	)	-RRB-
cord-021419-nypnib0h	133	30	.	.	.
cord-021419-nypnib0h	134	1	The	the	DT
cord-021419-nypnib0h	134	2	acylation	acylation	NN
cord-021419-nypnib0h	134	3	of	of	IN
cord-021419-nypnib0h	134	4	14	14	CD
cord-021419-nypnib0h	134	5	with	with	IN
cord-021419-nypnib0h	134	6	1-adamantylmethyloxy	1-adamantylmethyloxy	CD
cord-021419-nypnib0h	134	7	carbonate	carbonate	NN
cord-021419-nypnib0h	134	8	(	(	-LRB-
cord-021419-nypnib0h	134	9	Adoc	Adoc	NNP
cord-021419-nypnib0h	134	10	2	2	CD
cord-021419-nypnib0h	134	11	O	O	NNP
cord-021419-nypnib0h	134	12	)	)	-RRB-
cord-021419-nypnib0h	134	13	affords	afford	VBZ
cord-021419-nypnib0h	134	14	the	the	DT
cord-021419-nypnib0h	134	15	N	N	NNP
cord-021419-nypnib0h	134	16	-	-	HYPH
cord-021419-nypnib0h	134	17	Adoc	Adoc	NNP
cord-021419-nypnib0h	134	18	-	-	HYPH
cord-021419-nypnib0h	134	19	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	134	20	aglycone	aglycone	NN
cord-021419-nypnib0h	134	21	(	(	-LRB-
cord-021419-nypnib0h	134	22	16	16	CD
cord-021419-nypnib0h	134	23	)	)	-RRB-
cord-021419-nypnib0h	134	24	(	(	-LRB-
cord-021419-nypnib0h	134	25	see	see	VB
cord-021419-nypnib0h	134	26	Fig	Fig	NNP
cord-021419-nypnib0h	134	27	.	.	.
cord-021419-nypnib0h	135	1	1	1	LS
cord-021419-nypnib0h	135	2	f	f	NN
cord-021419-nypnib0h	135	3	,	,	,
cord-021419-nypnib0h	135	4	Scheme	scheme	NN
cord-021419-nypnib0h	135	5	4	4	CD
cord-021419-nypnib0h	135	6	)	)	-RRB-
cord-021419-nypnib0h	135	7	.	.	.
cord-021419-nypnib0h	136	1	Compounds	compound	NNS
cord-021419-nypnib0h	136	2	12b	12b	NNS
cord-021419-nypnib0h	136	3	,	,	,
cord-021419-nypnib0h	136	4	13b	13b	NNS
cord-021419-nypnib0h	136	5	and	and	CC
cord-021419-nypnib0h	136	6	14	14	CD
cord-021419-nypnib0h	136	7	±	±	CD
cord-021419-nypnib0h	136	8	16	16	CD
cord-021419-nypnib0h	136	9	exhibit	exhibit	NN
cord-021419-nypnib0h	136	10	high	high	JJ
cord-021419-nypnib0h	137	1	in	in	IN
cord-021419-nypnib0h	137	2	vitro	vitro	FW
cord-021419-nypnib0h	137	3	activity	activity	NN
cord-021419-nypnib0h	137	4	against	against	IN
cord-021419-nypnib0h	137	5	different	different	JJ
cord-021419-nypnib0h	137	6	corona	corona	NN
cord-021419-nypnib0h	137	7	-	-	HYPH
cord-021419-nypnib0h	137	8	and	and	CC
cord-021419-nypnib0h	137	9	flaviviruses	flavivirus	NNS
cord-021419-nypnib0h	137	10	,	,	,
cord-021419-nypnib0h	137	11	in	in	IN
cord-021419-nypnib0h	137	12	partic	partic	JJ
cord-021419-nypnib0h	137	13	-	-	HYPH
cord-021419-nypnib0h	137	14	ular	ular	JJ
cord-021419-nypnib0h	137	15	feline	feline	JJ
cord-021419-nypnib0h	137	16	infectious	infectious	JJ
cord-021419-nypnib0h	137	17	peritonitis	peritonitis	NN
cord-021419-nypnib0h	137	18	virus	virus	NN
cord-021419-nypnib0h	137	19	(	(	-LRB-
cord-021419-nypnib0h	137	20	FIPV	FIPV	NNP
cord-021419-nypnib0h	137	21	)	)	-RRB-
cord-021419-nypnib0h	137	22	and	and	CC
cord-021419-nypnib0h	137	23	the	the	DT
cord-021419-nypnib0h	137	24	coronavirus	coronavirus	NN
cord-021419-nypnib0h	137	25	(	(	-LRB-
cord-021419-nypnib0h	137	26	SARS	SARS	NNP
cord-021419-nypnib0h	137	27	-	-	HYPH
cord-021419-nypnib0h	137	28	CoV	CoV	NNP
cord-021419-nypnib0h	137	29	)	)	-RRB-
cord-021419-nypnib0h	137	30	.	.	.
cord-021419-nypnib0h	138	1	24	24	CD
cord-021419-nypnib0h	139	1	The	the	DT
cord-021419-nypnib0h	139	2	most	most	RBS
cord-021419-nypnib0h	139	3	interesting	interesting	JJ
cord-021419-nypnib0h	139	4	data	datum	NNS
cord-021419-nypnib0h	139	5	were	be	VBD
cord-021419-nypnib0h	139	6	obtained	obtain	VBN
cord-021419-nypnib0h	139	7	when	when	WRB
cord-021419-nypnib0h	139	8	studying	study	VBG
cord-021419-nypnib0h	139	9	antiviral	antiviral	JJ
cord-021419-nypnib0h	139	10	activity	activity	NN
cord-021419-nypnib0h	139	11	of	of	IN
cord-021419-nypnib0h	139	12	(	(	-LRB-
cord-021419-nypnib0h	139	13	1-adamantylmethyl)amide	1-adamantylmethyl)amide	CD
cord-021419-nypnib0h	139	14	of	of	IN
cord-021419-nypnib0h	139	15	the	the	DT
cord-021419-nypnib0h	139	16	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	139	17	aglycone	aglycone	NNP
cord-021419-nypnib0h	139	18	(	(	-LRB-
cord-021419-nypnib0h	139	19	12b	12b	CD
cord-021419-nypnib0h	139	20	)	)	-RRB-
cord-021419-nypnib0h	139	21	and	and	CC
cord-021419-nypnib0h	139	22	its	-PRON-	PRP$
cord-021419-nypnib0h	139	23	de-(D	de-(D	NNS
cord-021419-nypnib0h	139	24	-	-	HYPH
cord-021419-nypnib0h	139	25	MeLeu	MeLeu	NNP
cord-021419-nypnib0h	139	26	)	)	-RRB-
cord-021419-nypnib0h	139	27	analogue	analogue	NN
cord-021419-nypnib0h	139	28	(	(	-LRB-
cord-021419-nypnib0h	139	29	13b	13b	CD
cord-021419-nypnib0h	139	30	)	)	-RRB-
cord-021419-nypnib0h	139	31	against	against	IN
cord-021419-nypnib0h	139	32	human	human	JJ
cord-021419-nypnib0h	139	33	immunodeficiency	immunodeficiency	NN
cord-021419-nypnib0h	139	34	viruses	virus	NNS
cord-021419-nypnib0h	139	35	(	(	-LRB-
cord-021419-nypnib0h	139	36	HIV	HIV	NNP
cord-021419-nypnib0h	139	37	)	)	-RRB-
cord-021419-nypnib0h	139	38	:	:	:
cord-021419-nypnib0h	139	39	IC	IC	NNP
cord-021419-nypnib0h	139	40	50	50	CD
cord-021419-nypnib0h	139	41	=	=	SYM
cord-021419-nypnib0h	139	42	1.6	1.6	CD
cord-021419-nypnib0h	139	43	and	and	CC
cord-021419-nypnib0h	139	44	5.5	5.5	CD
cord-021419-nypnib0h	139	45	mmol	mmol	NN
cord-021419-nypnib0h	139	46	L	L	NNP
cord-021419-nypnib0h	139	47	71	71	CD
cord-021419-nypnib0h	139	48	for	for	IN
cord-021419-nypnib0h	139	49	HIV-1	HIV-1	NNP
cord-021419-nypnib0h	139	50	,	,	,
cord-021419-nypnib0h	139	51	7.0	7.0	CD
cord-021419-nypnib0h	139	52	and	and	CC
cord-021419-nypnib0h	139	53	3.5	3.5	CD
cord-021419-nypnib0h	139	54	mmol	mmol	NN
cord-021419-nypnib0h	139	55	L	L	NNP
cord-021419-nypnib0h	139	56	71	71	CD
cord-021419-nypnib0h	139	57	for	for	IN
cord-021419-nypnib0h	139	58	HIV-2	HIV-2	NNP
cord-021419-nypnib0h	139	59	,	,	,
cord-021419-nypnib0h	139	60	respectively	respectively	RB
cord-021419-nypnib0h	139	61	.	.	.
cord-021419-nypnib0h	140	1	Compounds	compound	NNS
cord-021419-nypnib0h	140	2	of	of	IN
cord-021419-nypnib0h	140	3	type	type	NN
cord-021419-nypnib0h	140	4	13b	13b	NNS
cord-021419-nypnib0h	140	5	are	be	VBP
cord-021419-nypnib0h	140	6	promising	promise	VBG
cord-021419-nypnib0h	140	7	selective	selective	JJ
cord-021419-nypnib0h	140	8	anti	anti	JJ
cord-021419-nypnib0h	140	9	-	-	JJ
cord-021419-nypnib0h	140	10	HIV	hiv	JJ
cord-021419-nypnib0h	140	11	agents	agent	NNS
cord-021419-nypnib0h	140	12	because	because	IN
cord-021419-nypnib0h	140	13	they	-PRON-	PRP
cord-021419-nypnib0h	140	14	can	can	MD
cord-021419-nypnib0h	140	15	not	not	RB
cord-021419-nypnib0h	140	16	bind	bind	VB
cord-021419-nypnib0h	140	17	to	to	IN
cord-021419-nypnib0h	140	18	bacterial	bacterial	JJ
cord-021419-nypnib0h	140	19	targets	target	NNS
cord-021419-nypnib0h	140	20	.	.	.
cord-021419-nypnib0h	141	1	23	23	CD
cord-021419-nypnib0h	142	1	Apparently	apparently	RB
cord-021419-nypnib0h	142	2	,	,	,
cord-021419-nypnib0h	142	3	they	-PRON-	PRP
cord-021419-nypnib0h	142	4	can	can	MD
cord-021419-nypnib0h	142	5	not	not	RB
cord-021419-nypnib0h	142	6	induce	induce	VB
cord-021419-nypnib0h	142	7	resistance	resistance	NN
cord-021419-nypnib0h	142	8	of	of	IN
cord-021419-nypnib0h	142	9	bacteria	bacteria	NNS
cord-021419-nypnib0h	142	10	during	during	IN
cord-021419-nypnib0h	142	11	long	long	JJ
cord-021419-nypnib0h	142	12	-	-	HYPH
cord-021419-nypnib0h	142	13	term	term	NN
cord-021419-nypnib0h	142	14	application	application	NN
cord-021419-nypnib0h	142	15	and	and	CC
cord-021419-nypnib0h	142	16	can	can	MD
cord-021419-nypnib0h	142	17	be	be	VB
cord-021419-nypnib0h	142	18	used	use	VBN
cord-021419-nypnib0h	142	19	in	in	IN
cord-021419-nypnib0h	142	20	the	the	DT
cord-021419-nypnib0h	142	21	future	future	NN
cord-021419-nypnib0h	142	22	for	for	IN
cord-021419-nypnib0h	142	23	the	the	DT
cord-021419-nypnib0h	142	24	prevention	prevention	NN
cord-021419-nypnib0h	142	25	of	of	IN
cord-021419-nypnib0h	142	26	HIV	HIV	NNP
cord-021419-nypnib0h	142	27	infections	infection	NNS
cord-021419-nypnib0h	142	28	.	.	.
cord-021419-nypnib0h	143	1	The	the	DT
cord-021419-nypnib0h	143	2	doubly	doubly	RB
cord-021419-nypnib0h	143	3	modified	modify	VBN
cord-021419-nypnib0h	143	4	teicoplanin	teicoplanin	NN
cord-021419-nypnib0h	143	5	derivative	derivative	JJ
cord-021419-nypnib0h	143	6	Ð	Ð	NNP
cord-021419-nypnib0h	143	7	N	N	NNP
cord-021419-nypnib0h	143	8	-	-	HYPH
cord-021419-nypnib0h	143	9	Bocprotected	Bocprotected	NNP
cord-021419-nypnib0h	143	10	2-adamantylamide	2-adamantylamide	CD
cord-021419-nypnib0h	143	11	of	of	IN
cord-021419-nypnib0h	143	12	the	the	DT
cord-021419-nypnib0h	143	13	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	143	14	aglycone	aglycone	NNP
cord-021419-nypnib0h	143	15	15	15	CD
cord-021419-nypnib0h	143	16	Ð	Ð	NNP
cord-021419-nypnib0h	143	17	exhibits	exhibit	VBZ
cord-021419-nypnib0h	143	18	high	high	JJ
cord-021419-nypnib0h	143	19	in	in	IN
cord-021419-nypnib0h	143	20	vitro	vitro	FW
cord-021419-nypnib0h	143	21	activity	activity	NN
cord-021419-nypnib0h	143	22	against	against	IN
cord-021419-nypnib0h	143	23	a	a	DT
cord-021419-nypnib0h	143	24	series	series	NN
cord-021419-nypnib0h	143	25	of	of	IN
cord-021419-nypnib0h	143	26	flaviviruses	flavivirus	NNS
cord-021419-nypnib0h	143	27	:	:	:
cord-021419-nypnib0h	143	28	hepatitis	hepatitis	NNP
cord-021419-nypnib0h	143	29	C	C	NNP
cord-021419-nypnib0h	143	30	virus	virus	NN
cord-021419-nypnib0h	143	31	(	(	-LRB-
cord-021419-nypnib0h	143	32	HCV	HCV	NNP
cord-021419-nypnib0h	143	33	)	)	-RRB-
cord-021419-nypnib0h	143	34	,	,	,
cord-021419-nypnib0h	143	35	25	25	CD
cord-021419-nypnib0h	143	36	yellow	yellow	JJ
cord-021419-nypnib0h	143	37	fever	fever	NN
cord-021419-nypnib0h	143	38	virus	virus	NN
cord-021419-nypnib0h	143	39	(	(	-LRB-
cord-021419-nypnib0h	143	40	YFV	YFV	NNP
cord-021419-nypnib0h	143	41	)	)	-RRB-
cord-021419-nypnib0h	143	42	,	,	,
cord-021419-nypnib0h	143	43	Japanese	japanese	JJ
cord-021419-nypnib0h	143	44	encephalitis	encephalitis	RB
cord-021419-nypnib0h	143	45	virus	virus	NN
cord-021419-nypnib0h	143	46	(	(	-LRB-
cord-021419-nypnib0h	143	47	JEV	JEV	NNP
cord-021419-nypnib0h	143	48	)	)	-RRB-
cord-021419-nypnib0h	143	49	,	,	,
cord-021419-nypnib0h	143	50	tick	tick	VB
cord-021419-nypnib0h	143	51	-	-	HYPH
cord-021419-nypnib0h	143	52	borne	bear	VBN
cord-021419-nypnib0h	143	53	encephalitis	encephalitis	JJ
cord-021419-nypnib0h	143	54	virus	virus	NN
cord-021419-nypnib0h	143	55	TBEV	TBEV	NNP
cord-021419-nypnib0h	143	56	)	)	-RRB-
cord-021419-nypnib0h	143	57	and	and	CC
cord-021419-nypnib0h	143	58	Dengue	Dengue	NNP
cord-021419-nypnib0h	143	59	virus	virus	NN
cord-021419-nypnib0h	143	60	(	(	-LRB-
cord-021419-nypnib0h	143	61	DENV	DENV	NNP
cord-021419-nypnib0h	143	62	)	)	-RRB-
cord-021419-nypnib0h	143	63	.	.	.
cord-021419-nypnib0h	144	1	25	25	CD
cord-021419-nypnib0h	144	2	,	,	,
cord-021419-nypnib0h	144	3	26	26	CD
cord-021419-nypnib0h	144	4	Compound	Compound	NNP
cord-021419-nypnib0h	144	5	15	15	CD
cord-021419-nypnib0h	144	6	is	be	VBZ
cord-021419-nypnib0h	144	7	unique	unique	JJ
cord-021419-nypnib0h	144	8	in	in	IN
cord-021419-nypnib0h	144	9	that	that	IN
cord-021419-nypnib0h	144	10	it	-PRON-	PRP
cord-021419-nypnib0h	144	11	can	can	MD
cord-021419-nypnib0h	144	12	inhibit	inhibit	VB
cord-021419-nypnib0h	144	13	replication	replication	NN
cord-021419-nypnib0h	144	14	of	of	IN
cord-021419-nypnib0h	144	15	the	the	DT
cord-021419-nypnib0h	144	16	closely	closely	RB
cord-021419-nypnib0h	144	17	related	related	JJ
cord-021419-nypnib0h	144	18	DENV	DENV	NNP
cord-021419-nypnib0h	144	19	and	and	CC
cord-021419-nypnib0h	144	20	HCV	HCV	NNP
cord-021419-nypnib0h	144	21	viruses	virus	NNS
cord-021419-nypnib0h	144	22	by	by	IN
cord-021419-nypnib0h	144	23	different	different	JJ
cord-021419-nypnib0h	144	24	mechanisms	mechanism	NNS
cord-021419-nypnib0h	144	25	:	:	:
cord-021419-nypnib0h	145	1	in	in	IN
cord-021419-nypnib0h	145	2	the	the	DT
cord-021419-nypnib0h	145	3	former	former	JJ
cord-021419-nypnib0h	145	4	case	case	NN
cord-021419-nypnib0h	145	5	,	,	,
cord-021419-nypnib0h	145	6	the	the	DT
cord-021419-nypnib0h	145	7	inhibition	inhibition	NN
cord-021419-nypnib0h	145	8	occurs	occur	VBZ
cord-021419-nypnib0h	145	9	in	in	IN
cord-021419-nypnib0h	145	10	the	the	DT
cord-021419-nypnib0h	145	11	stage	stage	NN
cord-021419-nypnib0h	145	12	of	of	IN
cord-021419-nypnib0h	145	13	virus	virus	NN
cord-021419-nypnib0h	145	14	entry	entry	NN
cord-021419-nypnib0h	145	15	in	in	IN
cord-021419-nypnib0h	145	16	the	the	DT
cord-021419-nypnib0h	145	17	host	host	NN
cord-021419-nypnib0h	145	18	cell	cell	NN
cord-021419-nypnib0h	145	19	;	;	:
cord-021419-nypnib0h	145	20	in	in	IN
cord-021419-nypnib0h	145	21	the	the	DT
cord-021419-nypnib0h	145	22	latter	latter	JJ
cord-021419-nypnib0h	145	23	case	case	NN
cord-021419-nypnib0h	145	24	,	,	,
cord-021419-nypnib0h	145	25	after	after	IN
cord-021419-nypnib0h	145	26	virus	virus	NN
cord-021419-nypnib0h	145	27	entry	entry	NN
cord-021419-nypnib0h	145	28	.	.	.
cord-021419-nypnib0h	146	1	Protein	protein	NN
cord-021419-nypnib0h	146	2	kinases	kinase	NNS
cord-021419-nypnib0h	146	3	play	play	VBP
cord-021419-nypnib0h	146	4	an	an	DT
cord-021419-nypnib0h	146	5	essential	essential	JJ
cord-021419-nypnib0h	146	6	role	role	NN
cord-021419-nypnib0h	146	7	in	in	IN
cord-021419-nypnib0h	146	8	the	the	DT
cord-021419-nypnib0h	146	9	virus	virus	NN
cord-021419-nypnib0h	146	10	entry	entry	NN
cord-021419-nypnib0h	146	11	in	in	IN
cord-021419-nypnib0h	146	12	the	the	DT
cord-021419-nypnib0h	146	13	cell	cell	NN
cord-021419-nypnib0h	146	14	and	and	CC
cord-021419-nypnib0h	146	15	virus	virus	NN
cord-021419-nypnib0h	146	16	replication	replication	NN
cord-021419-nypnib0h	146	17	.	.	.
cord-021419-nypnib0h	147	1	Hence	hence	RB
cord-021419-nypnib0h	147	2	,	,	,
cord-021419-nypnib0h	147	3	15	15	CD
cord-021419-nypnib0h	147	4	analogues	analogue	NNS
cord-021419-nypnib0h	147	5	of	of	IN
cord-021419-nypnib0h	147	6	the	the	DT
cord-021419-nypnib0h	147	7	eremomycin	eremomycin	NNS
cord-021419-nypnib0h	147	8	and	and	CC
cord-021419-nypnib0h	147	9	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	147	10	aglycones	aglycones	NNP
cord-021419-nypnib0h	147	11	(	(	-LRB-
cord-021419-nypnib0h	147	12	including	include	VBG
cord-021419-nypnib0h	147	13	compounds	compound	NNS
cord-021419-nypnib0h	147	14	12a	12a	NNS
cord-021419-nypnib0h	147	15	,	,	,
cord-021419-nypnib0h	147	16	b	b	NN
cord-021419-nypnib0h	147	17	,	,	,
cord-021419-nypnib0h	147	18	13a	13a	NNS
cord-021419-nypnib0h	147	19	,	,	,
cord-021419-nypnib0h	148	1	b	b	NN
cord-021419-nypnib0h	148	2	and	and	CC
cord-021419-nypnib0h	148	3	14	14	CD
cord-021419-nypnib0h	148	4	±	±	CD
cord-021419-nypnib0h	148	5	16	16	CD
cord-021419-nypnib0h	148	6	)	)	-RRB-
cord-021419-nypnib0h	148	7	were	be	VBD
cord-021419-nypnib0h	148	8	tested	test	VBN
cord-021419-nypnib0h	148	9	on	on	IN
cord-021419-nypnib0h	148	10	a	a	DT
cord-021419-nypnib0h	148	11	panel	panel	NN
cord-021419-nypnib0h	148	12	of	of	IN
cord-021419-nypnib0h	148	13	12	12	CD
cord-021419-nypnib0h	148	14	recombinant	recombinant	JJ
cord-021419-nypnib0h	148	15	human	human	JJ
cord-021419-nypnib0h	148	16	protein	protein	NN
cord-021419-nypnib0h	148	17	kinases	kinase	NNS
cord-021419-nypnib0h	148	18	(	(	-LRB-
cord-021419-nypnib0h	148	19	PKs	pk	NNS
cord-021419-nypnib0h	148	20	)	)	-RRB-
cord-021419-nypnib0h	148	21	and	and	CC
cord-021419-nypnib0h	148	22	two	two	CD
cord-021419-nypnib0h	148	23	rat	rat	NN
cord-021419-nypnib0h	148	24	liver	liver	NN
cord-021419-nypnib0h	148	25	PKs	pk	NNS
cord-021419-nypnib0h	148	26	(	(	-LRB-
cord-021419-nypnib0h	148	27	CK1	CK1	NNP
cord-021419-nypnib0h	148	28	and	and	CC
cord-021419-nypnib0h	148	29	CK2	CK2	NNP
cord-021419-nypnib0h	148	30	)	)	-RRB-
cord-021419-nypnib0h	148	31	.	.	.
cord-021419-nypnib0h	149	1	27	27	CD
cord-021419-nypnib0h	150	1	These	these	DT
cord-021419-nypnib0h	150	2	compounds	compound	NNS
cord-021419-nypnib0h	150	3	were	be	VBD
cord-021419-nypnib0h	150	4	shown	show	VBN
cord-021419-nypnib0h	150	5	to	to	TO
cord-021419-nypnib0h	150	6	inhibit	inhibit	VB
cord-021419-nypnib0h	150	7	PK	PK	NNP
cord-021419-nypnib0h	150	8	activity	activity	NN
cord-021419-nypnib0h	150	9	by	by	IN
cord-021419-nypnib0h	150	10	50	50	CD
cord-021419-nypnib0h	150	11	%	%	NN
cord-021419-nypnib0h	150	12	at	at	IN
cord-021419-nypnib0h	150	13	a	a	DT
cord-021419-nypnib0h	150	14	concentration	concentration	NN
cord-021419-nypnib0h	150	15	of	of	IN
cord-021419-nypnib0h	150	16	<	<	NNP
cord-021419-nypnib0h	150	17	10	10	CD
cord-021419-nypnib0h	150	18	mmol	mmol	JJ
cord-021419-nypnib0h	150	19	L	L	NNP
cord-021419-nypnib0h	150	20	71	71	CD
cord-021419-nypnib0h	150	21	and	and	CC
cord-021419-nypnib0h	150	22	by	by	IN
cord-021419-nypnib0h	150	23	90	90	CD
cord-021419-nypnib0h	150	24	%	%	NN
cord-021419-nypnib0h	150	25	at	at	IN
cord-021419-nypnib0h	150	26	a	a	DT
cord-021419-nypnib0h	150	27	concentration	concentration	NN
cord-021419-nypnib0h	150	28	of	of	IN
cord-021419-nypnib0h	150	29	10	10	CD
cord-021419-nypnib0h	150	30	mmol	mmol	JJ
cord-021419-nypnib0h	150	31	L	L	NNP
cord-021419-nypnib0h	150	32	71	71	CD
cord-021419-nypnib0h	150	33	.	.	.
cord-021419-nypnib0h	151	1	Teicoplanin	teicoplanin	JJ
cord-021419-nypnib0h	151	2	aglycone	aglycone	NNP
cord-021419-nypnib0h	151	3	derivatives	derivative	NNS
cord-021419-nypnib0h	151	4	15	15	CD
cord-021419-nypnib0h	151	5	and	and	CC
cord-021419-nypnib0h	151	6	16	16	CD
cord-021419-nypnib0h	151	7	exhibit	exhibit	NN
cord-021419-nypnib0h	151	8	higher	high	JJR
cord-021419-nypnib0h	151	9	activity	activity	NN
cord-021419-nypnib0h	151	10	against	against	IN
cord-021419-nypnib0h	151	11	many	many	JJ
cord-021419-nypnib0h	151	12	PKs	pk	NNS
cord-021419-nypnib0h	151	13	compared	compare	VBN
cord-021419-nypnib0h	151	14	to	to	IN
cord-021419-nypnib0h	151	15	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	151	16	derivatives	derivative	NNS
cord-021419-nypnib0h	151	17	12b	12b	NNS
cord-021419-nypnib0h	151	18	and	and	CC
cord-021419-nypnib0h	151	19	13b	13b	NNS
cord-021419-nypnib0h	151	20	,	,	,
cord-021419-nypnib0h	151	21	which	which	WDT
cord-021419-nypnib0h	151	22	also	also	RB
cord-021419-nypnib0h	151	23	correlates	correlate	VBZ
cord-021419-nypnib0h	151	24	with	with	IN
cord-021419-nypnib0h	151	25	their	-PRON-	PRP$
cord-021419-nypnib0h	151	26	higher	high	JJR
cord-021419-nypnib0h	151	27	activity	activity	NN
cord-021419-nypnib0h	151	28	against	against	IN
cord-021419-nypnib0h	151	29	many	many	JJ
cord-021419-nypnib0h	151	30	types	type	NNS
cord-021419-nypnib0h	151	31	of	of	IN
cord-021419-nypnib0h	151	32	enveloped	envelop	VBN
cord-021419-nypnib0h	151	33	viruses	virus	NNS
cord-021419-nypnib0h	151	34	.	.	.
cord-021419-nypnib0h	152	1	The	the	DT
cord-021419-nypnib0h	152	2	kinetic	kinetic	JJ
cord-021419-nypnib0h	152	3	analysis	analysis	NN
cord-021419-nypnib0h	152	4	of	of	IN
cord-021419-nypnib0h	152	5	the	the	DT
cord-021419-nypnib0h	152	6	inhibition	inhibition	NN
cord-021419-nypnib0h	152	7	of	of	IN
cord-021419-nypnib0h	152	8	protein	protein	NN
cord-021419-nypnib0h	152	9	kinase	kinase	NN
cord-021419-nypnib0h	152	10	CK2a	CK2a	NNP
cord-021419-nypnib0h	152	11	demonstrated	demonstrate	VBD
cord-021419-nypnib0h	152	12	that	that	IN
cord-021419-nypnib0h	152	13	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	152	14	N	N	NNP
cord-021419-nypnib0h	152	15	-	-	HYPH
cord-021419-nypnib0h	152	16	Adoc	Adoc	NNP
cord-021419-nypnib0h	152	17	-	-	HYPH
cord-021419-nypnib0h	152	18	aglycone	aglycone	NNP
cord-021419-nypnib0h	152	19	16	16	CD
cord-021419-nypnib0h	152	20	does	do	VBZ
cord-021419-nypnib0h	152	21	not	not	RB
cord-021419-nypnib0h	152	22	compete	compete	VB
cord-021419-nypnib0h	152	23	with	with	IN
cord-021419-nypnib0h	152	24	ATP	ATP	NNP
cord-021419-nypnib0h	152	25	and	and	CC
cord-021419-nypnib0h	152	26	peptide	peptide	NN
cord-021419-nypnib0h	152	27	substrates	substrate	NNS
cord-021419-nypnib0h	152	28	.	.	.
cord-021419-nypnib0h	153	1	27	27	CD
cord-021419-nypnib0h	153	2	on	on	IN
cord-021419-nypnib0h	153	3	the	the	DT
cord-021419-nypnib0h	153	4	available	available	JJ
cord-021419-nypnib0h	153	5	data	datum	NNS
cord-021419-nypnib0h	153	6	,	,	,
cord-021419-nypnib0h	153	7	it	-PRON-	PRP
cord-021419-nypnib0h	153	8	was	be	VBD
cord-021419-nypnib0h	153	9	suggested	suggest	VBN
cord-021419-nypnib0h	153	10	that	that	IN
cord-021419-nypnib0h	153	11	one	one	CD
cord-021419-nypnib0h	153	12	of	of	IN
cord-021419-nypnib0h	153	13	the	the	DT
cord-021419-nypnib0h	153	14	mechanisms	mechanism	NNS
cord-021419-nypnib0h	153	15	of	of	IN
cord-021419-nypnib0h	153	16	antiviral	antiviral	JJ
cord-021419-nypnib0h	153	17	activity	activity	NN
cord-021419-nypnib0h	153	18	of	of	IN
cord-021419-nypnib0h	153	19	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	153	20	derivatives	derivative	NNS
cord-021419-nypnib0h	153	21	can	can	MD
cord-021419-nypnib0h	153	22	be	be	VB
cord-021419-nypnib0h	153	23	based	base	VBN
cord-021419-nypnib0h	153	24	on	on	IN
cord-021419-nypnib0h	153	25	the	the	DT
cord-021419-nypnib0h	153	26	inhibition	inhibition	NN
cord-021419-nypnib0h	153	27	of	of	IN
cord-021419-nypnib0h	153	28	serine	serine	NN
cord-021419-nypnib0h	153	29	/	/	SYM
cord-021419-nypnib0h	153	30	threonine	threonine	NN
cord-021419-nypnib0h	153	31	protein	protein	NN
cord-021419-nypnib0h	153	32	kinases	kinase	NNS
cord-021419-nypnib0h	153	33	.	.	.
cord-021419-nypnib0h	154	1	The	the	DT
cord-021419-nypnib0h	154	2	synthesis	synthesis	NN
cord-021419-nypnib0h	154	3	of	of	IN
cord-021419-nypnib0h	154	4	hybrid	hybrid	JJ
cord-021419-nypnib0h	154	5	analogues	analogue	NNS
cord-021419-nypnib0h	154	6	containing	contain	VBG
cord-021419-nypnib0h	154	7	covalently	covalently	RB
cord-021419-nypnib0h	154	8	bonded	bond	VBN
cord-021419-nypnib0h	154	9	compounds	compound	NNS
cord-021419-nypnib0h	154	10	of	of	IN
cord-021419-nypnib0h	154	11	different	different	JJ
cord-021419-nypnib0h	154	12	classes	class	NNS
cord-021419-nypnib0h	154	13	(	(	-LRB-
cord-021419-nypnib0h	154	14	dual	dual	RB
cord-021419-nypnib0h	154	15	-	-	HYPH
cord-021419-nypnib0h	154	16	acting	act	VBG
cord-021419-nypnib0h	154	17	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	154	18	)	)	-RRB-
cord-021419-nypnib0h	154	19	with	with	IN
cord-021419-nypnib0h	154	20	different	different	JJ
cord-021419-nypnib0h	154	21	spectra	spectrum	NNS
cord-021419-nypnib0h	154	22	of	of	IN
cord-021419-nypnib0h	154	23	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	154	24	activity	activity	NN
cord-021419-nypnib0h	154	25	is	be	VBZ
cord-021419-nypnib0h	154	26	a	a	DT
cord-021419-nypnib0h	154	27	promising	promising	JJ
cord-021419-nypnib0h	154	28	approach	approach	NN
cord-021419-nypnib0h	154	29	to	to	IN
cord-021419-nypnib0h	154	30	the	the	DT
cord-021419-nypnib0h	154	31	search	search	NN
cord-021419-nypnib0h	154	32	for	for	IN
cord-021419-nypnib0h	154	33	new	new	JJ
cord-021419-nypnib0h	154	34	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	154	35	agents	agent	NNS
cord-021419-nypnib0h	154	36	to	to	TO
cord-021419-nypnib0h	154	37	combat	combat	VB
cord-021419-nypnib0h	154	38	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	154	39	resistance	resistance	NN
cord-021419-nypnib0h	154	40	of	of	IN
cord-021419-nypnib0h	154	41	bacteria	bacteria	NNS
cord-021419-nypnib0h	154	42	.	.	.
cord-021419-nypnib0h	155	1	28	28	CD
cord-021419-nypnib0h	155	2	,	,	,
cord-021419-nypnib0h	155	3	29	29	CD
cord-021419-nypnib0h	155	4	Boronic	Boronic	NNP
cord-021419-nypnib0h	155	5	acids	acid	NNS
cord-021419-nypnib0h	155	6	and	and	CC
cord-021419-nypnib0h	155	7	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	155	8	are	be	VBP
cord-021419-nypnib0h	155	9	compounds	compound	NNS
cord-021419-nypnib0h	155	10	capable	capable	JJ
cord-021419-nypnib0h	155	11	of	of	IN
cord-021419-nypnib0h	155	12	interacting	interact	VBG
cord-021419-nypnib0h	155	13	with	with	IN
cord-021419-nypnib0h	155	14	various	various	JJ
cord-021419-nypnib0h	155	15	biologically	biologically	RB
cord-021419-nypnib0h	155	16	important	important	JJ
cord-021419-nypnib0h	155	17	components	component	NNS
cord-021419-nypnib0h	155	18	of	of	IN
cord-021419-nypnib0h	155	19	the	the	DT
cord-021419-nypnib0h	155	20	living	live	VBG
cord-021419-nypnib0h	155	21	cell	cell	NN
cord-021419-nypnib0h	155	22	,	,	,
cord-021419-nypnib0h	155	23	such	such	JJ
cord-021419-nypnib0h	155	24	as	as	IN
cord-021419-nypnib0h	155	25	alcohols	alcohol	NNS
cord-021419-nypnib0h	155	26	,	,	,
cord-021419-nypnib0h	155	27	amino	amino	JJ
cord-021419-nypnib0h	155	28	alcohols	alcohol	NNS
cord-021419-nypnib0h	155	29	,	,	,
cord-021419-nypnib0h	155	30	carbohydrates	carbohydrate	NNS
cord-021419-nypnib0h	155	31	,	,	,
cord-021419-nypnib0h	155	32	RNA	RNA	NNP
cord-021419-nypnib0h	155	33	and	and	CC
cord-021419-nypnib0h	155	34	some	some	DT
cord-021419-nypnib0h	155	35	peptides	peptide	NNS
cord-021419-nypnib0h	155	36	.	.	.
cord-021419-nypnib0h	156	1	A	a	DT
cord-021419-nypnib0h	156	2	new	new	JJ
cord-021419-nypnib0h	156	3	class	class	NN
cord-021419-nypnib0h	156	4	of	of	IN
cord-021419-nypnib0h	156	5	synthetic	synthetic	JJ
cord-021419-nypnib0h	156	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	156	7	possessing	possess	VBG
cord-021419-nypnib0h	156	8	antifungal	antifungal	JJ
cord-021419-nypnib0h	156	9	,	,	,
cord-021419-nypnib0h	156	10	antimicrobial	antimicrobial	JJ
cord-021419-nypnib0h	156	11	and	and	CC
cord-021419-nypnib0h	156	12	antiparasitic	antiparasitic	JJ
cord-021419-nypnib0h	156	13	activity	activity	NN
cord-021419-nypnib0h	156	14	was	be	VBD
cord-021419-nypnib0h	156	15	designed	design	VBN
cord-021419-nypnib0h	156	16	and	and	CC
cord-021419-nypnib0h	156	17	synthesized	synthesize	VBN
cord-021419-nypnib0h	156	18	based	base	VBN
cord-021419-nypnib0h	156	19	on	on	IN
cord-021419-nypnib0h	156	20	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	156	21	and	and	CC
cord-021419-nypnib0h	156	22	is	be	VBZ
cord-021419-nypnib0h	156	23	currently	currently	RB
cord-021419-nypnib0h	156	24	developed	develop	VBN
cord-021419-nypnib0h	156	25	by	by	IN
cord-021419-nypnib0h	156	26	Anacor	Anacor	NNP
cord-021419-nypnib0h	156	27	Pharmaceuticals	Pharmaceuticals	NNP
cord-021419-nypnib0h	156	28	(	(	-LRB-
cord-021419-nypnib0h	156	29	USA	USA	NNP
cord-021419-nypnib0h	156	30	)	)	-RRB-
cord-021419-nypnib0h	156	31	.	.	.
cord-021419-nypnib0h	157	1	30	30	CD
cord-021419-nypnib0h	158	1	Certain	certain	JJ
cord-021419-nypnib0h	158	2	starting	start	VBG
cord-021419-nypnib0h	158	3	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	158	4	used	use	VBN
cord-021419-nypnib0h	158	5	in	in	IN
cord-021419-nypnib0h	158	6	the	the	DT
cord-021419-nypnib0h	158	7	synthesis	synthesis	NN
cord-021419-nypnib0h	158	8	also	also	RB
cord-021419-nypnib0h	158	9	exhibit	exhibit	VBP
cord-021419-nypnib0h	158	10	biological	biological	JJ
cord-021419-nypnib0h	158	11	activity	activity	NN
cord-021419-nypnib0h	158	12	(	(	-LRB-
cord-021419-nypnib0h	158	13	see	see	VB
cord-021419-nypnib0h	158	14	below	below	RB
cord-021419-nypnib0h	158	15	)	)	-RRB-
cord-021419-nypnib0h	158	16	.	.	.
cord-021419-nypnib0h	159	1	Series	series	NN
cord-021419-nypnib0h	159	2	of	of	IN
cord-021419-nypnib0h	159	3	hybrid	hybrid	JJ
cord-021419-nypnib0h	159	4	analogues	analogue	NNS
cord-021419-nypnib0h	159	5	17	17	CD
cord-021419-nypnib0h	159	6	±	±	NNP
cord-021419-nypnib0h	159	7	20	20	CD
cord-021419-nypnib0h	159	8	linked	link	VBN
cord-021419-nypnib0h	159	9	to	to	IN
cord-021419-nypnib0h	159	10	the	the	DT
cord-021419-nypnib0h	159	11	borole	borole	NNP
cord-021419-nypnib0h	159	12	or	or	CC
cord-021419-nypnib0h	159	13	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	159	14	moiety	moiety	NN
cord-021419-nypnib0h	159	15	either	either	CC
cord-021419-nypnib0h	159	16	directly	directly	RB
cord-021419-nypnib0h	159	17	or	or	CC
cord-021419-nypnib0h	159	18	through	through	IN
cord-021419-nypnib0h	159	19	a	a	DT
cord-021419-nypnib0h	159	20	spacer	spacer	NN
cord-021419-nypnib0h	159	21	were	be	VBD
cord-021419-nypnib0h	159	22	synthesized	synthesize	VBN
cord-021419-nypnib0h	159	23	for	for	IN
cord-021419-nypnib0h	159	24	the	the	DT
cord-021419-nypnib0h	159	25	first	first	JJ
cord-021419-nypnib0h	159	26	time	time	NN
cord-021419-nypnib0h	159	27	from	from	IN
cord-021419-nypnib0h	159	28	glycopeptides	glycopeptides	NNP
cord-021419-nypnib0h	159	29	1	1	CD
cord-021419-nypnib0h	159	30	and	and	CC
cord-021419-nypnib0h	159	31	3	3	CD
cord-021419-nypnib0h	159	32	.	.	.
cord-021419-nypnib0h	160	1	To	to	TO
cord-021419-nypnib0h	160	2	introduce	introduce	VB
cord-021419-nypnib0h	160	3	a	a	DT
cord-021419-nypnib0h	160	4	substituent	substituent	NN
cord-021419-nypnib0h	160	5	containing	contain	VBG
cord-021419-nypnib0h	160	6	a	a	DT
cord-021419-nypnib0h	160	7	boronic	boronic	JJ
cord-021419-nypnib0h	160	8	acid	acid	NN
cord-021419-nypnib0h	160	9	moiety	moiety	NN
cord-021419-nypnib0h	160	10	into	into	IN
cord-021419-nypnib0h	160	11	molecule	molecule	NN
cord-021419-nypnib0h	160	12	1	1	CD
cord-021419-nypnib0h	160	13	or	or	CC
cord-021419-nypnib0h	160	14	3	3	CD
cord-021419-nypnib0h	160	15	,	,	,
cord-021419-nypnib0h	160	16	it	-PRON-	PRP
cord-021419-nypnib0h	160	17	is	be	VBZ
cord-021419-nypnib0h	160	18	necessary	necessary	JJ
cord-021419-nypnib0h	160	19	to	to	TO
cord-021419-nypnib0h	160	20	employ	employ	VB
cord-021419-nypnib0h	160	21	picolinic	picolinic	JJ
cord-021419-nypnib0h	160	22	acid	acid	NN
cord-021419-nypnib0h	160	23	as	as	IN
cord-021419-nypnib0h	160	24	a	a	DT
cord-021419-nypnib0h	160	25	protecting	protect	VBG
cord-021419-nypnib0h	160	26	group	group	NN
cord-021419-nypnib0h	160	27	,	,	,
cord-021419-nypnib0h	160	28	which	which	WDT
cord-021419-nypnib0h	160	29	is	be	VBZ
cord-021419-nypnib0h	160	30	easily	easily	RB
cord-021419-nypnib0h	160	31	removed	remove	VBN
cord-021419-nypnib0h	160	32	in	in	IN
cord-021419-nypnib0h	160	33	a	a	DT
cord-021419-nypnib0h	160	34	weakly	weakly	RB
cord-021419-nypnib0h	160	35	acidic	acidic	JJ
cord-021419-nypnib0h	160	36	medium	medium	NN
cord-021419-nypnib0h	160	37	(	(	-LRB-
cord-021419-nypnib0h	160	38	Scheme	scheme	NN
cord-021419-nypnib0h	160	39	5	5	CD
cord-021419-nypnib0h	160	40	)	)	-RRB-
cord-021419-nypnib0h	160	41	.	.	.
cord-021419-nypnib0h	161	1	31	31	CD
cord-021419-nypnib0h	162	1	The	the	DT
cord-021419-nypnib0h	162	2	amidation	amidation	NN
cord-021419-nypnib0h	162	3	of	of	IN
cord-021419-nypnib0h	162	4	the	the	DT
cord-021419-nypnib0h	162	5	carboxyl	carboxyl	NN
cord-021419-nypnib0h	162	6	group	group	NN
cord-021419-nypnib0h	162	7	of	of	IN
cord-021419-nypnib0h	162	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	162	9	1	1	CD
cord-021419-nypnib0h	162	10	and	and	CC
cord-021419-nypnib0h	162	11	3	3	CD
cord-021419-nypnib0h	162	12	with	with	IN
cord-021419-nypnib0h	162	13	4-or	4-or	CD
cord-021419-nypnib0h	162	14	3-aminomethylphenylboronic	3-aminomethylphenylboronic	CD
cord-021419-nypnib0h	162	15	acid	acid	NN
cord-021419-nypnib0h	162	16	picolinate	picolinate	NN
cord-021419-nypnib0h	162	17	esters	ester	NNS
cord-021419-nypnib0h	162	18	in	in	IN
cord-021419-nypnib0h	162	19	the	the	DT
cord-021419-nypnib0h	162	20	presence	presence	NN
cord-021419-nypnib0h	162	21	of	of	IN
cord-021419-nypnib0h	162	22	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	162	23	gave	give	VBD
cord-021419-nypnib0h	162	24	new	new	JJ
cord-021419-nypnib0h	162	25	carboxamides	carboxamide	NNS
cord-021419-nypnib0h	162	26	of	of	IN
cord-021419-nypnib0h	162	27	these	these	DT
cord-021419-nypnib0h	162	28	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	162	29	(	(	-LRB-
cord-021419-nypnib0h	162	30	17a	17a	NNS
cord-021419-nypnib0h	162	31	±	±	CD
cord-021419-nypnib0h	162	32	20a	20a	NNS
cord-021419-nypnib0h	162	33	)	)	-RRB-
cord-021419-nypnib0h	162	34	.	.	.
cord-021419-nypnib0h	163	1	The	the	DT
cord-021419-nypnib0h	163	2	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	163	3	of	of	IN
cord-021419-nypnib0h	163	4	the	the	DT
cord-021419-nypnib0h	163	5	picolinic	picolinic	NNP
cord-021419-nypnib0h	163	6	group	group	NN
cord-021419-nypnib0h	163	7	under	under	IN
cord-021419-nypnib0h	163	8	mild	mild	JJ
cord-021419-nypnib0h	163	9	conditions	condition	NNS
cord-021419-nypnib0h	163	10	in	in	IN
cord-021419-nypnib0h	163	11	a	a	DT
cord-021419-nypnib0h	163	12	weakly	weakly	RB
cord-021419-nypnib0h	163	13	acidic	acidic	JJ
cord-021419-nypnib0h	163	14	aqueous	aqueous	JJ
cord-021419-nypnib0h	163	15	medium	medium	NN
cord-021419-nypnib0h	163	16	affords	afford	VBZ
cord-021419-nypnib0h	163	17	derivatives	derivative	NNS
cord-021419-nypnib0h	163	18	17b	17b	NNS
cord-021419-nypnib0h	163	19	±	±	CD
cord-021419-nypnib0h	163	20	20b	20b	NNS
cord-021419-nypnib0h	163	21	containing	contain	VBG
cord-021419-nypnib0h	163	22	the	the	DT
cord-021419-nypnib0h	163	23	unprotected	unprotected	JJ
cord-021419-nypnib0h	163	24	boronic	boronic	JJ
cord-021419-nypnib0h	163	25	acid	acid	NN
cord-021419-nypnib0h	163	26	moiety	moiety	NN
cord-021419-nypnib0h	163	27	.	.	.
cord-021419-nypnib0h	164	1	Borole	Borole	NNP
cord-021419-nypnib0h	164	2	-	-	HYPH
cord-021419-nypnib0h	164	3	containing	contain	VBG
cord-021419-nypnib0h	164	4	derivatives	derivative	NNS
cord-021419-nypnib0h	164	5	17	17	CD
cord-021419-nypnib0h	165	1	±	±	NNP
cord-021419-nypnib0h	165	2	20	20	CD
cord-021419-nypnib0h	165	3	were	be	VBD
cord-021419-nypnib0h	165	4	found	find	VBN
cord-021419-nypnib0h	165	5	to	to	TO
cord-021419-nypnib0h	165	6	be	be	VB
cord-021419-nypnib0h	165	7	as	as	RB
cord-021419-nypnib0h	165	8	effective	effective	JJ
cord-021419-nypnib0h	165	9	as	as	IN
cord-021419-nypnib0h	165	10	the	the	DT
cord-021419-nypnib0h	165	11	starting	start	VBG
cord-021419-nypnib0h	165	12	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	165	13	1	1	CD
cord-021419-nypnib0h	165	14	and	and	CC
cord-021419-nypnib0h	165	15	3	3	CD
cord-021419-nypnib0h	165	16	.	.	.
cord-021419-nypnib0h	166	1	Eremomycin	eremomycin	JJ
cord-021419-nypnib0h	166	2	derivative	derivative	JJ
cord-021419-nypnib0h	166	3	19b	19b	NNS
cord-021419-nypnib0h	166	4	exhibits	exhibit	VBZ
cord-021419-nypnib0h	166	5	the	the	DT
cord-021419-nypnib0h	166	6	highest	high	JJS
cord-021419-nypnib0h	166	7	activity	activity	NN
cord-021419-nypnib0h	166	8	against	against	IN
cord-021419-nypnib0h	166	9	Gram	gram	NN
cord-021419-nypnib0h	166	10	-	-	HYPH
cord-021419-nypnib0h	166	11	positive	positive	JJ
cord-021419-nypnib0h	166	12	bacteria	bacteria	NNS
cord-021419-nypnib0h	166	13	and	and	CC
cord-021419-nypnib0h	166	14	is	be	VBZ
cord-021419-nypnib0h	166	15	more	more	RBR
cord-021419-nypnib0h	166	16	effective	effective	JJ
cord-021419-nypnib0h	166	17	against	against	IN
cord-021419-nypnib0h	166	18	resistant	resistant	JJ
cord-021419-nypnib0h	166	19	staphylococcus	staphylococcus	NN
cord-021419-nypnib0h	166	20	strains	strain	NNS
cord-021419-nypnib0h	166	21	(	(	-LRB-
cord-021419-nypnib0h	166	22	VISA	VISA	NNP
cord-021419-nypnib0h	166	23	)	)	-RRB-
cord-021419-nypnib0h	166	24	compared	compare	VBN
cord-021419-nypnib0h	166	25	to	to	IN
cord-021419-nypnib0h	166	26	compounds	compound	NNS
cord-021419-nypnib0h	166	27	1	1	CD
cord-021419-nypnib0h	166	28	and	and	CC
cord-021419-nypnib0h	166	29	3	3	CD
cord-021419-nypnib0h	166	30	.	.	.
cord-021419-nypnib0h	167	1	A	a	DT
cord-021419-nypnib0h	167	2	series	series	NN
cord-021419-nypnib0h	167	3	of	of	IN
cord-021419-nypnib0h	167	4	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	167	5	conjugates	conjugate	NNS
cord-021419-nypnib0h	167	6	containing	contain	VBG
cord-021419-nypnib0h	167	7	different	different	JJ
cord-021419-nypnib0h	167	8	types	type	NNS
cord-021419-nypnib0h	167	9	of	of	IN
cord-021419-nypnib0h	167	10	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	167	11	substituents	substituent	NNS
cord-021419-nypnib0h	167	12	were	be	VBD
cord-021419-nypnib0h	167	13	synthesized	synthesize	VBN
cord-021419-nypnib0h	167	14	:	:	:
cord-021419-nypnib0h	167	15	amido	amido	NN
cord-021419-nypnib0h	167	16	derivatives	derivative	NNS
cord-021419-nypnib0h	167	17	21a	21a	NNS
cord-021419-nypnib0h	167	18	,	,	,
cord-021419-nypnib0h	167	19	b	b	NN
cord-021419-nypnib0h	167	20	,	,	,
cord-021419-nypnib0h	167	21	N	n	CD
cord-021419-nypnib0h	167	22	-	-	HYPH
cord-021419-nypnib0h	167	23	acyl	acyl	NNP
cord-021419-nypnib0h	167	24	derivatives	derivative	NNS
cord-021419-nypnib0h	167	25	(	(	-LRB-
cord-021419-nypnib0h	167	26	22	22	CD
cord-021419-nypnib0h	167	27	)	)	-RRB-
cord-021419-nypnib0h	167	28	N	n	CD
cord-021419-nypnib0h	167	29	-	-	HYPH
cord-021419-nypnib0h	167	30	alkyl	alkyl	JJ
cord-021419-nypnib0h	167	31	derivatives	derivative	NNS
cord-021419-nypnib0h	167	32	(	(	-LRB-
cord-021419-nypnib0h	167	33	23	23	CD
cord-021419-nypnib0h	167	34	)	)	-RRB-
cord-021419-nypnib0h	168	1	(	(	-LRB-
cord-021419-nypnib0h	168	2	Scheme	scheme	NN
cord-021419-nypnib0h	168	3	6	6	CD
cord-021419-nypnib0h	168	4	)	)	-RRB-
cord-021419-nypnib0h	168	5	.	.	.
cord-021419-nypnib0h	169	1	Similar	similar	JJ
cord-021419-nypnib0h	169	2	schemes	scheme	NNS
cord-021419-nypnib0h	169	3	were	be	VBD
cord-021419-nypnib0h	169	4	applied	apply	VBN
cord-021419-nypnib0h	169	5	to	to	TO
cord-021419-nypnib0h	169	6	synthesize	synthesize	VB
cord-021419-nypnib0h	169	7	benzoxaborole	benzoxaborole	JJ
cord-021419-nypnib0h	169	8	derivatives	derivative	NNS
cord-021419-nypnib0h	169	9	of	of	IN
cord-021419-nypnib0h	169	10	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	169	11	(	(	-LRB-
cord-021419-nypnib0h	169	12	7	7	CD
cord-021419-nypnib0h	169	13	)	)	-RRB-
cord-021419-nypnib0h	169	14	(	(	-LRB-
cord-021419-nypnib0h	169	15	see	see	VB
cord-021419-nypnib0h	169	16	Scheme	scheme	NN
cord-021419-nypnib0h	169	17	1	1	CD
cord-021419-nypnib0h	169	18	)	)	-RRB-
cord-021419-nypnib0h	169	19	and	and	CC
cord-021419-nypnib0h	169	20	the	the	DT
cord-021419-nypnib0h	169	21	teicoplanin	teicoplanin	JJ
cord-021419-nypnib0h	169	22	aglycone	aglycone	NNP
cord-021419-nypnib0h	169	23	(	(	-LRB-
cord-021419-nypnib0h	169	24	Scheme	Scheme	NNP
cord-021419-nypnib0h	169	25	7	7	CD
cord-021419-nypnib0h	169	26	)	)	-RRB-
cord-021419-nypnib0h	169	27	.	.	.
cord-021419-nypnib0h	170	1	32	32	CD
cord-021419-nypnib0h	170	2	Carboxamides	carboxamide	NNS
cord-021419-nypnib0h	170	3	of	of	IN
cord-021419-nypnib0h	170	4	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	170	5	(	(	-LRB-
cord-021419-nypnib0h	170	6	7	7	CD
cord-021419-nypnib0h	170	7	)	)	-RRB-
cord-021419-nypnib0h	170	8	(	(	-LRB-
cord-021419-nypnib0h	170	9	see	see	VB
cord-021419-nypnib0h	170	10	Scheme	scheme	NN
cord-021419-nypnib0h	170	11	1	1	CD
cord-021419-nypnib0h	170	12	)	)	-RRB-
cord-021419-nypnib0h	170	13	,	,	,
cord-021419-nypnib0h	170	14	vancomycin	vancomycin	FW
cord-021419-nypnib0h	170	15	(	(	-LRB-
cord-021419-nypnib0h	170	16	21a	21a	NNS
cord-021419-nypnib0h	170	17	)	)	-RRB-
cord-021419-nypnib0h	171	1	(	(	-LRB-
cord-021419-nypnib0h	171	2	see	see	VB
cord-021419-nypnib0h	171	3	Scheme	Scheme	NNP
cord-021419-nypnib0h	171	4	6	6	CD
cord-021419-nypnib0h	171	5	)	)	-RRB-
cord-021419-nypnib0h	171	6	and	and	CC
cord-021419-nypnib0h	171	7	the	the	DT
cord-021419-nypnib0h	171	8	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	171	9	aglycone	aglycone	NNP
cord-021419-nypnib0h	171	10	(	(	-LRB-
cord-021419-nypnib0h	171	11	24a	24a	CD
cord-021419-nypnib0h	171	12	)	)	-RRB-
cord-021419-nypnib0h	172	1	(	(	-LRB-
cord-021419-nypnib0h	172	2	see	see	VB
cord-021419-nypnib0h	172	3	Scheme	Scheme	NNP
cord-021419-nypnib0h	172	4	7	7	CD
cord-021419-nypnib0h	172	5	)	)	-RRB-
cord-021419-nypnib0h	172	6	were	be	VBD
cord-021419-nypnib0h	172	7	synthesized	synthesize	VBN
cord-021419-nypnib0h	172	8	by	by	IN
cord-021419-nypnib0h	172	9	a	a	DT
cord-021419-nypnib0h	172	10	standard	standard	JJ
cord-021419-nypnib0h	172	11	procedure	procedure	NN
cord-021419-nypnib0h	172	12	based	base	VBN
cord-021419-nypnib0h	172	13	on	on	IN
cord-021419-nypnib0h	172	14	the	the	DT
cord-021419-nypnib0h	172	15	treatment	treatment	NN
cord-021419-nypnib0h	172	16	of	of	IN
cord-021419-nypnib0h	172	17	compounds	compound	NNS
cord-021419-nypnib0h	172	18	1	1	CD
cord-021419-nypnib0h	172	19	,	,	,
cord-021419-nypnib0h	172	20	3	3	CD
cord-021419-nypnib0h	172	21	and	and	CC
cord-021419-nypnib0h	172	22	14	14	CD
cord-021419-nypnib0h	172	23	,	,	,
cord-021419-nypnib0h	172	24	respectively	respectively	RB
cord-021419-nypnib0h	172	25	,	,	,
cord-021419-nypnib0h	172	26	with	with	IN
cord-021419-nypnib0h	172	27	3-(aminomethyl)benzo[c	3-(aminomethyl)benzo[c	CD
cord-021419-nypnib0h	172	28	]	]	-RRB-
cord-021419-nypnib0h	172	29	[	[	-LRB-
cord-021419-nypnib0h	172	30	1	1	CD
cord-021419-nypnib0h	172	31	,	,	,
cord-021419-nypnib0h	172	32	2	2	CD
cord-021419-nypnib0h	172	33	]	]	-RRB-
cord-021419-nypnib0h	173	1	oxaborol-1(3H)-ol	oxaborol-1(3H)-ol	NNS
cord-021419-nypnib0h	173	2	in	in	IN
cord-021419-nypnib0h	173	3	the	the	DT
cord-021419-nypnib0h	173	4	presence	presence	NN
cord-021419-nypnib0h	173	5	of	of	IN
cord-021419-nypnib0h	173	6	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	173	7	.	.	.
cord-021419-nypnib0h	174	1	The	the	DT
cord-021419-nypnib0h	174	2	reaction	reaction	NN
cord-021419-nypnib0h	174	3	of	of	IN
cord-021419-nypnib0h	174	4	compound	compound	NN
cord-021419-nypnib0h	174	5	1	1	CD
cord-021419-nypnib0h	174	6	or	or	CC
cord-021419-nypnib0h	174	7	14	14	CD
cord-021419-nypnib0h	174	8	with	with	IN
cord-021419-nypnib0h	174	9	o	o	NN
cord-021419-nypnib0h	174	10	-	-	HYPH
cord-021419-nypnib0h	174	11	amino	amino	NN
cord-021419-nypnib0h	174	12	-	-	HYPH
cord-021419-nypnib0h	174	13	n	n	NN
cord-021419-nypnib0h	174	14	-	-	HYPH
cord-021419-nypnib0h	174	15	alkylamines	alkylamines	NNP
cord-021419-nypnib0h	174	16	affords	afford	VBZ
cord-021419-nypnib0h	174	17	the	the	DT
cord-021419-nypnib0h	174	18	corresponding	correspond	VBG
cord-021419-nypnib0h	174	19	amides	amide	NNS
cord-021419-nypnib0h	174	20	21b	21b	NNS
cord-021419-nypnib0h	174	21	and	and	CC
cord-021419-nypnib0h	174	22	24b	24b	NNS
cord-021419-nypnib0h	174	23	,	,	,
cord-021419-nypnib0h	174	24	c	c	NNP
cord-021419-nypnib0h	174	25	(	(	-LRB-
cord-021419-nypnib0h	174	26	n	n	NN
cord-021419-nypnib0h	174	27	=	=	SYM
cord-021419-nypnib0h	174	28	2	2	CD
cord-021419-nypnib0h	174	29	,	,	,
cord-021419-nypnib0h	174	30	3	3	CD
cord-021419-nypnib0h	174	31	and	and	CC
cord-021419-nypnib0h	174	32	5	5	LS
cord-021419-nypnib0h	174	33	)	)	-RRB-
cord-021419-nypnib0h	174	34	containing	contain	VBG
cord-021419-nypnib0h	174	35	a	a	DT
cord-021419-nypnib0h	174	36	longer	long	JJR
cord-021419-nypnib0h	174	37	spacer	spacer	NN
cord-021419-nypnib0h	174	38	.	.	.
cord-021419-nypnib0h	175	1	The	the	DT
cord-021419-nypnib0h	175	2	reactions	reaction	NNS
cord-021419-nypnib0h	175	3	with	with	IN
cord-021419-nypnib0h	175	4	OSu	OSu	NNS
cord-021419-nypnib0h	175	5	-	-	HYPH
cord-021419-nypnib0h	175	6	activated	activate	VBN
cord-021419-nypnib0h	175	7	esters	ester	NNS
cord-021419-nypnib0h	175	8	of	of	IN
cord-021419-nypnib0h	175	9	the	the	DT
cord-021419-nypnib0h	175	10	same	same	JJ
cord-021419-nypnib0h	175	11	in	in	IN
cord-021419-nypnib0h	175	12	situ	situ	NN
cord-021419-nypnib0h	175	13	generated	generate	VBN
cord-021419-nypnib0h	175	14	compounds	compound	NNS
cord-021419-nypnib0h	175	15	were	be	VBD
cord-021419-nypnib0h	175	16	used	use	VBN
cord-021419-nypnib0h	175	17	to	to	TO
cord-021419-nypnib0h	175	18	synthesize	synthesize	VB
cord-021419-nypnib0h	175	19	N-[3-(1-hydroxy-1,3-dihydrobenzo[c	N-[3-(1-hydroxy-1,3-dihydrobenzo[c	NNP
cord-021419-nypnib0h	175	20	]	]	-RRB-
cord-021419-nypnib0h	175	21	[	[	-LRB-
cord-021419-nypnib0h	175	22	1	1	CD
cord-021419-nypnib0h	175	23	,	,	,
cord-021419-nypnib0h	175	24	2	2	CD
cord-021419-nypnib0h	175	25	]	]	-RRB-
cord-021419-nypnib0h	175	26	oxaborol-7-yl)propanoyl	oxaborol-7-yl)propanoyl	NN
cord-021419-nypnib0h	175	27	]	]	-RRB-
cord-021419-nypnib0h	175	28	derivatives	derivative	NNS
cord-021419-nypnib0h	175	29	of	of	IN
cord-021419-nypnib0h	175	30	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	175	31	(	(	-LRB-
cord-021419-nypnib0h	175	32	22	22	CD
cord-021419-nypnib0h	175	33	)	)	-RRB-
cord-021419-nypnib0h	175	34	and	and	CC
cord-021419-nypnib0h	175	35	the	the	DT
cord-021419-nypnib0h	175	36	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	175	37	aglycone	aglycone	NNP
cord-021419-nypnib0h	175	38	(	(	-LRB-
cord-021419-nypnib0h	175	39	25a	25a	NNS
cord-021419-nypnib0h	175	40	)	)	-RRB-
cord-021419-nypnib0h	175	41	.	.	.
cord-021419-nypnib0h	176	1	The	the	DT
cord-021419-nypnib0h	176	2	alkylation	alkylation	NN
cord-021419-nypnib0h	176	3	of	of	IN
cord-021419-nypnib0h	176	4	vancomycin	vancomycin	NN
cord-021419-nypnib0h	176	5	(	(	-LRB-
cord-021419-nypnib0h	176	6	1	1	CD
cord-021419-nypnib0h	176	7	)	)	-RRB-
cord-021419-nypnib0h	176	8	with	with	IN
cord-021419-nypnib0h	176	9	appropriate	appropriate	JJ
cord-021419-nypnib0h	176	10	aldehyde	aldehyde	NN
cord-021419-nypnib0h	176	11	in	in	IN
cord-021419-nypnib0h	176	12	the	the	DT
cord-021419-nypnib0h	176	13	presence	presence	NN
cord-021419-nypnib0h	176	14	of	of	IN
cord-021419-nypnib0h	176	15	NaBH	NaBH	NNP
cord-021419-nypnib0h	176	16	3	3	CD
cord-021419-nypnib0h	176	17	CN	CN	NNP
cord-021419-nypnib0h	176	18	affords	afford	VBZ
cord-021419-nypnib0h	176	19	N	N	NNP
cord-021419-nypnib0h	176	20	,	,	,
cord-021419-nypnib0h	176	21	N	n	CD
cord-021419-nypnib0h	176	22	Hdi(1-hydroxy-1,3-dihydrobenzo[c	hdi(1-hydroxy-1,3-dihydrobenzo[c	NN
cord-021419-nypnib0h	176	23	]	]	-RRB-
cord-021419-nypnib0h	176	24	[	[	-LRB-
cord-021419-nypnib0h	176	25	1	1	CD
cord-021419-nypnib0h	176	26	,	,	,
cord-021419-nypnib0h	176	27	2	2	CD
cord-021419-nypnib0h	176	28	]	]	-RRB-
cord-021419-nypnib0h	176	29	oxaborole-6-methyl)vancomycin	oxaborole-6-methyl)vancomycin	NNPS
cord-021419-nypnib0h	176	30	(	(	-LRB-
cord-021419-nypnib0h	176	31	23	23	CD
cord-021419-nypnib0h	176	32	)	)	-RRB-
cord-021419-nypnib0h	176	33	in	in	IN
cord-021419-nypnib0h	176	34	quantitative	quantitative	JJ
cord-021419-nypnib0h	176	35	yield	yield	NN
cord-021419-nypnib0h	176	36	(	(	-LRB-
cord-021419-nypnib0h	176	37	see	see	VB
cord-021419-nypnib0h	176	38	Scheme	Scheme	NNP
cord-021419-nypnib0h	176	39	6	6	CD
cord-021419-nypnib0h	176	40	)	)	-RRB-
cord-021419-nypnib0h	176	41	.	.	.
cord-021419-nypnib0h	177	1	32	32	CD
cord-021419-nypnib0h	178	1	The	the	DT
cord-021419-nypnib0h	178	2	amidation	amidation	NN
cord-021419-nypnib0h	178	3	of	of	IN
cord-021419-nypnib0h	178	4	N	N	NNP
cord-021419-nypnib0h	178	5	-	-	HYPH
cord-021419-nypnib0h	178	6	acyl	acyl	NN
cord-021419-nypnib0h	178	7	-	-	HYPH
cord-021419-nypnib0h	178	8	substituted	substitute	VBN
cord-021419-nypnib0h	178	9	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	178	10	aglycone	aglycone	NNP
cord-021419-nypnib0h	178	11	25a	25a	NNS
cord-021419-nypnib0h	178	12	with	with	IN
cord-021419-nypnib0h	178	13	appropriate	appropriate	JJ
cord-021419-nypnib0h	178	14	amine	amine	NN
cord-021419-nypnib0h	178	15	(	(	-LRB-
cord-021419-nypnib0h	178	16	in	in	IN
cord-021419-nypnib0h	178	17	a	a	DT
cord-021419-nypnib0h	178	18	similar	similar	JJ
cord-021419-nypnib0h	178	19	way	way	NN
cord-021419-nypnib0h	178	20	as	as	IN
cord-021419-nypnib0h	178	21	the	the	DT
cord-021419-nypnib0h	178	22	synthesis	synthesis	NN
cord-021419-nypnib0h	178	23	of	of	IN
cord-021419-nypnib0h	178	24	amides	amide	NNS
cord-021419-nypnib0h	178	25	21	21	CD
cord-021419-nypnib0h	178	26	and	and	CC
cord-021419-nypnib0h	178	27	24a	24a	CD
cord-021419-nypnib0h	178	28	)	)	-RRB-
cord-021419-nypnib0h	179	1	gave	give	VBD
cord-021419-nypnib0h	179	2	disubstituted	disubstitute	VBN
cord-021419-nypnib0h	179	3	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	179	4	aglycone	aglycone	NNP
cord-021419-nypnib0h	179	5	derivative	derivative	JJ
cord-021419-nypnib0h	179	6	25b	25b	NNS
cord-021419-nypnib0h	179	7	.	.	.
cord-021419-nypnib0h	180	1	The	the	DT
cord-021419-nypnib0h	180	2	five	five	CD
cord-021419-nypnib0h	180	3	-	-	HYPH
cord-021419-nypnib0h	180	4	membered	membered	JJ
cord-021419-nypnib0h	180	5	oxaborole	oxaborole	NN
cord-021419-nypnib0h	180	6	ring	ring	NN
cord-021419-nypnib0h	180	7	cleavage	cleavage	NN
cord-021419-nypnib0h	180	8	is	be	VBZ
cord-021419-nypnib0h	180	9	not	not	RB
cord-021419-nypnib0h	180	10	observed	observe	VBN
cord-021419-nypnib0h	180	11	in	in	IN
cord-021419-nypnib0h	180	12	various	various	JJ
cord-021419-nypnib0h	180	13	reactions	reaction	NNS
cord-021419-nypnib0h	180	14	of	of	IN
cord-021419-nypnib0h	180	15	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	180	16	(	(	-LRB-
cord-021419-nypnib0h	180	17	see	see	VB
cord-021419-nypnib0h	180	18	Scheme	Scheme	NNP
cord-021419-nypnib0h	180	19	7	7	CD
cord-021419-nypnib0h	180	20	)	)	-RRB-
cord-021419-nypnib0h	180	21	.	.	.
cord-021419-nypnib0h	181	1	The	the	DT
cord-021419-nypnib0h	181	2	presence	presence	NN
cord-021419-nypnib0h	181	3	of	of	IN
cord-021419-nypnib0h	181	4	peaks	peak	NNS
cord-021419-nypnib0h	181	5	at	at	IN
cord-021419-nypnib0h	181	6	m	m	NNP
cord-021419-nypnib0h	181	7	/	/	SYM
cord-021419-nypnib0h	181	8	z	z	NN
cord-021419-nypnib0h	181	9	1619	1619	CD
cord-021419-nypnib0h	181	10	.	.	.
cord-021419-nypnib0h	182	1	49	49	CD
cord-021419-nypnib0h	182	2	[	[	-LRB-
cord-021419-nypnib0h	182	3	M7OH	M7OH	NNP
cord-021419-nypnib0h	182	4	]	]	-RRB-
cord-021419-nypnib0h	182	5	,	,	,
cord-021419-nypnib0h	182	6	1474.39	1474.39	CD
cord-021419-nypnib0h	182	7	and	and	CC
cord-021419-nypnib0h	182	8	lower	low	JJR
cord-021419-nypnib0h	182	9	(	(	-LRB-
cord-021419-nypnib0h	182	10	1312	1312	CD
cord-021419-nypnib0h	182	11	.	.	.
cord-021419-nypnib0h	183	1	34	34	CD
cord-021419-nypnib0h	183	2	and	and	CC
cord-021419-nypnib0h	183	3	1284.34	1284.34	CD
cord-021419-nypnib0h	183	4	)	)	-RRB-
cord-021419-nypnib0h	184	1	in	in	IN
cord-021419-nypnib0h	184	2	the	the	DT
cord-021419-nypnib0h	184	3	tandem	tandem	JJ
cord-021419-nypnib0h	184	4	mass	mass	NN
cord-021419-nypnib0h	184	5	spectrometry	spectrometry	NN
cord-021419-nypnib0h	184	6	(	(	-LRB-
cord-021419-nypnib0h	184	7	ESI	ESI	NNP
cord-021419-nypnib0h	184	8	-	-	HYPH
cord-021419-nypnib0h	184	9	MS	MS	NNP
cord-021419-nypnib0h	184	10	/	/	SYM
cord-021419-nypnib0h	184	11	MS	MS	NNP
cord-021419-nypnib0h	184	12	-	-	HYPH
cord-021419-nypnib0h	184	13	MRM	MRM	NNP
cord-021419-nypnib0h	184	14	)	)	-RRB-
cord-021419-nypnib0h	184	15	spectrum	spectrum	NNP
cord-021419-nypnib0h	184	16	of	of	IN
cord-021419-nypnib0h	184	17	compound	compound	NNP
cord-021419-nypnib0h	184	18	22	22	CD
cord-021419-nypnib0h	184	19	indicates	indicate	VBZ
cord-021419-nypnib0h	184	20	that	that	IN
cord-021419-nypnib0h	184	21	the	the	DT
cord-021419-nypnib0h	184	22	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	184	23	molecule	molecule	NN
cord-021419-nypnib0h	184	24	contains	contain	VBZ
cord-021419-nypnib0h	184	25	a	a	DT
cord-021419-nypnib0h	184	26	substituent	substituent	NN
cord-021419-nypnib0h	184	27	in	in	IN
cord-021419-nypnib0h	184	28	the	the	DT
cord-021419-nypnib0h	184	29	N	n	CD
cord-021419-nypnib0h	184	30	-	-	HYPH
cord-021419-nypnib0h	184	31	terminal	terminal	JJ
cord-021419-nypnib0h	184	32	amino	amino	NN
cord-021419-nypnib0h	184	33	group	group	NN
cord-021419-nypnib0h	184	34	of	of	IN
cord-021419-nypnib0h	184	35	the	the	DT
cord-021419-nypnib0h	184	36	peptide	peptide	NN
cord-021419-nypnib0h	184	37	core	core	NN
cord-021419-nypnib0h	184	38	rather	rather	RB
cord-021419-nypnib0h	184	39	than	than	IN
cord-021419-nypnib0h	184	40	in	in	IN
cord-021419-nypnib0h	184	41	the	the	DT
cord-021419-nypnib0h	184	42	amino	amino	NN
cord-021419-nypnib0h	184	43	sugar	sugar	NN
cord-021419-nypnib0h	184	44	N(3	N(3	NNP
cord-021419-nypnib0h	184	45	H	H	NNP
cord-021419-nypnib0h	184	46	)	)	-RRB-
cord-021419-nypnib0h	184	47	group	group	NN
cord-021419-nypnib0h	184	48	of	of	IN
cord-021419-nypnib0h	184	49	vancosamine	vancosamine	NNP
cord-021419-nypnib0h	184	50	(	(	-LRB-
cord-021419-nypnib0h	184	51	Fig	Fig	NNP
cord-021419-nypnib0h	184	52	.	.	.
cord-021419-nypnib0h	184	53	3	3	CD
cord-021419-nypnib0h	184	54	)	)	-RRB-
cord-021419-nypnib0h	184	55	.	.	.
cord-021419-nypnib0h	185	1	32	32	CD
cord-021419-nypnib0h	185	2	Vancomycin	Vancomycin	NNP
cord-021419-nypnib0h	185	3	derivatives	derivative	NNS
cord-021419-nypnib0h	185	4	21a	21a	NNS
cord-021419-nypnib0h	185	5	,	,	,
cord-021419-nypnib0h	185	6	22	22	CD
cord-021419-nypnib0h	185	7	and	and	CC
cord-021419-nypnib0h	185	8	23	23	CD
cord-021419-nypnib0h	185	9	proved	prove	VBD
cord-021419-nypnib0h	185	10	to	to	TO
cord-021419-nypnib0h	185	11	be	be	VB
cord-021419-nypnib0h	185	12	less	less	RBR
cord-021419-nypnib0h	185	13	effective	effective	JJ
cord-021419-nypnib0h	185	14	against	against	IN
cord-021419-nypnib0h	185	15	Gram	gram	NN
cord-021419-nypnib0h	185	16	-	-	HYPH
cord-021419-nypnib0h	185	17	positive	positive	JJ
cord-021419-nypnib0h	185	18	bacteria	bacteria	NNS
cord-021419-nypnib0h	185	19	than	than	IN
cord-021419-nypnib0h	185	20	the	the	DT
cord-021419-nypnib0h	185	21	starting	starting	NN
cord-021419-nypnib0h	185	22	compound	compound	NN
cord-021419-nypnib0h	185	23	1	1	CD
cord-021419-nypnib0h	185	24	,	,	,
cord-021419-nypnib0h	185	25	except	except	IN
cord-021419-nypnib0h	185	26	for	for	IN
cord-021419-nypnib0h	185	27	amide	amide	NN
cord-021419-nypnib0h	185	28	21a	21a	NNS
cord-021419-nypnib0h	185	29	,	,	,
cord-021419-nypnib0h	185	30	which	which	WDT
cord-021419-nypnib0h	185	31	exhibits	exhibit	VBZ
cord-021419-nypnib0h	185	32	activity	activity	NN
cord-021419-nypnib0h	185	33	comparable	comparable	JJ
cord-021419-nypnib0h	185	34	with	with	IN
cord-021419-nypnib0h	185	35	that	that	DT
cord-021419-nypnib0h	185	36	of	of	IN
cord-021419-nypnib0h	185	37	vancomycin	vancomycin	NN
cord-021419-nypnib0h	185	38	1	1	CD
cord-021419-nypnib0h	185	39	.	.	.
cord-021419-nypnib0h	186	1	32	32	CD
cord-021419-nypnib0h	186	2	Hybrid	hybrid	NN
cord-021419-nypnib0h	186	3	derivatives	derivative	NNS
cord-021419-nypnib0h	186	4	,	,	,
cord-021419-nypnib0h	186	5	in	in	IN
cord-021419-nypnib0h	186	6	which	which	WDT
cord-021419-nypnib0h	186	7	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	186	8	and	and	CC
cord-021419-nypnib0h	186	9	the	the	DT
cord-021419-nypnib0h	186	10	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	186	11	aglycone	aglycone	NNP
cord-021419-nypnib0h	186	12	are	be	VBP
cord-021419-nypnib0h	186	13	linked	link	VBN
cord-021419-nypnib0h	186	14	by	by	IN
cord-021419-nypnib0h	186	15	a	a	DT
cord-021419-nypnib0h	186	16	spacer	spacer	NN
cord-021419-nypnib0h	186	17	with	with	IN
cord-021419-nypnib0h	186	18	a	a	DT
cord-021419-nypnib0h	186	19	particular	particular	JJ
cord-021419-nypnib0h	186	20	length	length	NN
cord-021419-nypnib0h	186	21	,	,	,
cord-021419-nypnib0h	186	22	exhibited	exhibit	VBD
cord-021419-nypnib0h	186	23	the	the	DT
cord-021419-nypnib0h	186	24	highest	high	JJS
cord-021419-nypnib0h	186	25	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	186	26	activity	activity	NN
cord-021419-nypnib0h	186	27	against	against	IN
cord-021419-nypnib0h	186	28	clinical	clinical	JJ
cord-021419-nypnib0h	186	29	isolates	isolate	NNS
cord-021419-nypnib0h	186	30	of	of	IN
cord-021419-nypnib0h	186	31	Gram	gram	NN
cord-021419-nypnib0h	186	32	-	-	HYPH
cord-021419-nypnib0h	186	33	positive	positive	JJ
cord-021419-nypnib0h	186	34	bacteria	bacteria	NNS
cord-021419-nypnib0h	186	35	.	.	.
cord-021419-nypnib0h	187	1	3-Amino	3-amino	CD
cord-021419-nypnib0h	187	2	-	-	HYPH
cord-021419-nypnib0h	187	3	N-(1hydroxy-1,3-dihydro[c	N-(1hydroxy-1,3-dihydro[c	NNP
cord-021419-nypnib0h	187	4	]	]	-RRB-
cord-021419-nypnib0h	187	5	[	[	-LRB-
cord-021419-nypnib0h	187	6	1	1	CD
cord-021419-nypnib0h	187	7	,	,	,
cord-021419-nypnib0h	187	8	2	2	CD
cord-021419-nypnib0h	187	9	]	]	-RRB-
cord-021419-nypnib0h	187	10	oxaborol-6-yl)propylamide	oxaborol-6-yl)propylamide	NN
cord-021419-nypnib0h	187	11	of	of	IN
cord-021419-nypnib0h	187	12	the	the	DT
cord-021419-nypnib0h	187	13	teicoplanin	teicoplanin	NNP
cord-021419-nypnib0h	187	14	aglycone	aglycone	NNP
cord-021419-nypnib0h	187	15	(	(	-LRB-
cord-021419-nypnib0h	187	16	24c	24c	NNS
cord-021419-nypnib0h	187	17	,	,	,
cord-021419-nypnib0h	187	18	n	n	NN
cord-021419-nypnib0h	187	19	=	=	SYM
cord-021419-nypnib0h	187	20	2	2	CD
cord-021419-nypnib0h	187	21	)	)	-RRB-
cord-021419-nypnib0h	187	22	possesses	possess	VBZ
cord-021419-nypnib0h	187	23	particularly	particularly	RB
cord-021419-nypnib0h	187	24	high	high	JJ
cord-021419-nypnib0h	187	25	activity	activity	NN
cord-021419-nypnib0h	187	26	,	,	,
cord-021419-nypnib0h	187	27	in	in	IN
cord-021419-nypnib0h	187	28	particular	particular	JJ
cord-021419-nypnib0h	187	29	against	against	IN
cord-021419-nypnib0h	187	30	vancomycin	vancomycin	NN
cord-021419-nypnib0h	187	31	-	-	HYPH
cord-021419-nypnib0h	187	32	resistant	resistant	JJ
cord-021419-nypnib0h	187	33	strains	strain	NNS
cord-021419-nypnib0h	187	34	.	.	.
cord-021419-nypnib0h	188	1	32	32	CD
cord-021419-nypnib0h	189	1	Besides	besides	RB
cord-021419-nypnib0h	189	2	,	,	,
cord-021419-nypnib0h	189	3	this	this	DT
cord-021419-nypnib0h	189	4	compound	compound	NN
cord-021419-nypnib0h	189	5	exhibits	exhibit	VBZ
cord-021419-nypnib0h	189	6	moderate	moderate	JJ
cord-021419-nypnib0h	189	7	activity	activity	NN
cord-021419-nypnib0h	189	8	against	against	IN
cord-021419-nypnib0h	189	9	vancomycin	vancomycin	NN
cord-021419-nypnib0h	189	10	-	-	HYPH
cord-021419-nypnib0h	189	11	resistant	resistant	JJ
cord-021419-nypnib0h	189	12	enterococci	enterococci	NNS
cord-021419-nypnib0h	189	13	(	(	-LRB-
cord-021419-nypnib0h	189	14	VRE	VRE	NNP
cord-021419-nypnib0h	189	15	)	)	-RRB-
cord-021419-nypnib0h	189	16	;	;	:
cord-021419-nypnib0h	189	17	the	the	DT
cord-021419-nypnib0h	189	18	minimum	minimum	JJ
cord-021419-nypnib0h	189	19	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	189	20	concentration	concentration	NN
cord-021419-nypnib0h	189	21	(	(	-LRB-
cord-021419-nypnib0h	189	22	MIC	MIC	NNP
cord-021419-nypnib0h	189	23	)	)	-RRB-
cord-021419-nypnib0h	189	24	is	be	VBZ
cord-021419-nypnib0h	189	25	4	4	CD
cord-021419-nypnib0h	189	26	±	±	CD
cord-021419-nypnib0h	189	27	8	8	CD
cord-021419-nypnib0h	189	28	mg	mg	NNP
cord-021419-nypnib0h	189	29	mL	mL	NNP
cord-021419-nypnib0h	189	30	71	71	CD
cord-021419-nypnib0h	189	31	.	.	.
cord-021419-nypnib0h	190	1	An	an	DT
cord-021419-nypnib0h	190	2	increase	increase	NN
cord-021419-nypnib0h	190	3	or	or	CC
cord-021419-nypnib0h	190	4	a	a	DT
cord-021419-nypnib0h	190	5	decrease	decrease	NN
cord-021419-nypnib0h	190	6	in	in	IN
cord-021419-nypnib0h	190	7	the	the	DT
cord-021419-nypnib0h	190	8	spacer	spacer	NN
cord-021419-nypnib0h	190	9	length	length	NN
cord-021419-nypnib0h	190	10	and	and	CC
cord-021419-nypnib0h	190	11	the	the	DT
cord-021419-nypnib0h	190	12	introduction	introduction	NN
cord-021419-nypnib0h	190	13	of	of	IN
cord-021419-nypnib0h	190	14	two	two	CD
cord-021419-nypnib0h	190	15	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	190	16	substituents	substituent	NNS
cord-021419-nypnib0h	190	17	into	into	IN
cord-021419-nypnib0h	190	18	the	the	DT
cord-021419-nypnib0h	190	19	N	N	NNP
cord-021419-nypnib0h	190	20	-	-	HYPH
cord-021419-nypnib0h	190	21	and	and	CC
cord-021419-nypnib0h	190	22	C	C	NNP
cord-021419-nypnib0h	190	23	-	-	HYPH
cord-021419-nypnib0h	190	24	terminal	terminal	NN
cord-021419-nypnib0h	190	25	groups	group	NNS
cord-021419-nypnib0h	190	26	of	of	IN
cord-021419-nypnib0h	190	27	the	the	DT
cord-021419-nypnib0h	190	28	peptide	peptide	NN
cord-021419-nypnib0h	190	29	were	be	VBD
cord-021419-nypnib0h	190	30	found	find	VBN
cord-021419-nypnib0h	190	31	to	to	TO
cord-021419-nypnib0h	190	32	decrease	decrease	VB
cord-021419-nypnib0h	190	33	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	190	34	activity	activity	NN
cord-021419-nypnib0h	190	35	.	.	.
cord-021419-nypnib0h	191	1	The	the	DT
cord-021419-nypnib0h	191	2	broad	broad	JJ
cord-021419-nypnib0h	191	3	-	-	HYPH
cord-021419-nypnib0h	191	4	spectrum	spectrum	NN
cord-021419-nypnib0h	191	5	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	191	6	drug	drug	NN
cord-021419-nypnib0h	191	7	kanamycin	kanamycin	NNP
cord-021419-nypnib0h	191	8	A	A	NNP
cord-021419-nypnib0h	191	9	(	(	-LRB-
cord-021419-nypnib0h	191	10	26a	26a	NNP
cord-021419-nypnib0h	191	11	)	)	-RRB-
cord-021419-nypnib0h	191	12	is	be	VBZ
cord-021419-nypnib0h	191	13	an	an	DT
cord-021419-nypnib0h	191	14	important	important	JJ
cord-021419-nypnib0h	191	15	antibiotic	antibiotic	NN
cord-021419-nypnib0h	191	16	of	of	IN
cord-021419-nypnib0h	191	17	the	the	DT
cord-021419-nypnib0h	191	18	aminoglycoside	aminoglycoside	NNP
cord-021419-nypnib0h	191	19	(	(	-LRB-
cord-021419-nypnib0h	191	20	aminocyclitol	aminocyclitol	NNP
cord-021419-nypnib0h	191	21	)	)	-RRB-
cord-021419-nypnib0h	191	22	class	class	NN
cord-021419-nypnib0h	191	23	,	,	,
cord-021419-nypnib0h	191	24	which	which	WDT
cord-021419-nypnib0h	191	25	is	be	VBZ
cord-021419-nypnib0h	191	26	still	still	RB
cord-021419-nypnib0h	191	27	used	use	VBN
cord-021419-nypnib0h	191	28	in	in	IN
cord-021419-nypnib0h	191	29	medicine	medicine	NN
cord-021419-nypnib0h	191	30	for	for	IN
cord-021419-nypnib0h	191	31	the	the	DT
cord-021419-nypnib0h	191	32	treatment	treatment	NN
cord-021419-nypnib0h	191	33	of	of	IN
cord-021419-nypnib0h	191	34	many	many	JJ
cord-021419-nypnib0h	191	35	infectious	infectious	JJ
cord-021419-nypnib0h	191	36	diseases	disease	NNS
cord-021419-nypnib0h	191	37	and	and	CC
cord-021419-nypnib0h	191	38	also	also	RB
cord-021419-nypnib0h	191	39	in	in	IN
cord-021419-nypnib0h	191	40	agriculture	agriculture	NN
cord-021419-nypnib0h	191	41	.	.	.
cord-021419-nypnib0h	192	1	7	7	CD
cord-021419-nypnib0h	192	2	Aminoglycosides	aminoglycoside	NNS
cord-021419-nypnib0h	192	3	are	be	VBP
cord-021419-nypnib0h	192	4	active	active	JJ
cord-021419-nypnib0h	192	5	against	against	IN
cord-021419-nypnib0h	192	6	Gram	gram	NN
cord-021419-nypnib0h	192	7	-	-	HYPH
cord-021419-nypnib0h	192	8	positive	positive	JJ
cord-021419-nypnib0h	192	9	and	and	CC
cord-021419-nypnib0h	192	10	Gram	gram	NN
cord-021419-nypnib0h	192	11	-	-	HYPH
cord-021419-nypnib0h	192	12	negative	negative	JJ
cord-021419-nypnib0h	192	13	bacteria	bacteria	NNS
cord-021419-nypnib0h	192	14	.	.	.
cord-021419-nypnib0h	193	1	The	the	DT
cord-021419-nypnib0h	193	2	mechanism	mechanism	NN
cord-021419-nypnib0h	193	3	of	of	IN
cord-021419-nypnib0h	193	4	their	-PRON-	PRP$
cord-021419-nypnib0h	193	5	action	action	NN
cord-021419-nypnib0h	193	6	is	be	VBZ
cord-021419-nypnib0h	193	7	related	relate	VBN
cord-021419-nypnib0h	193	8	to	to	IN
cord-021419-nypnib0h	193	9	the	the	DT
cord-021419-nypnib0h	193	10	interaction	interaction	NN
cord-021419-nypnib0h	193	11	with	with	IN
cord-021419-nypnib0h	193	12	the	the	DT
cord-021419-nypnib0h	193	13	decoding	decode	VBG
cord-021419-nypnib0h	193	14	site	site	NN
cord-021419-nypnib0h	193	15	(	(	-LRB-
cord-021419-nypnib0h	193	16	A	a	DT
cord-021419-nypnib0h	193	17	site	site	NN
cord-021419-nypnib0h	193	18	)	)	-RRB-
cord-021419-nypnib0h	193	19	of	of	IN
cord-021419-nypnib0h	193	20	the	the	DT
cord-021419-nypnib0h	193	21	16S	16S	NNP
cord-021419-nypnib0h	193	22	subunit	subunit	NN
cord-021419-nypnib0h	193	23	of	of	IN
cord-021419-nypnib0h	193	24	ribosomal	ribosomal	JJ
cord-021419-nypnib0h	193	25	ribonucleic	ribonucleic	NN
cord-021419-nypnib0h	193	26	acid	acid	NN
cord-021419-nypnib0h	193	27	(	(	-LRB-
cord-021419-nypnib0h	193	28	rRNA	rRNA	NNP
cord-021419-nypnib0h	193	29	)	)	-RRB-
cord-021419-nypnib0h	193	30	,	,	,
cord-021419-nypnib0h	193	31	which	which	WDT
cord-021419-nypnib0h	193	32	leads	lead	VBZ
cord-021419-nypnib0h	193	33	to	to	IN
cord-021419-nypnib0h	193	34	disturbance	disturbance	NN
cord-021419-nypnib0h	193	35	of	of	IN
cord-021419-nypnib0h	193	36	translation	translation	NN
cord-021419-nypnib0h	193	37	,	,	,
cord-021419-nypnib0h	193	38	i.e.	i.e.	FW
cord-021419-nypnib0h	193	39	,	,	,
cord-021419-nypnib0h	193	40	protein	protein	NN
cord-021419-nypnib0h	193	41	biosynthesis	biosynthesis	NN
cord-021419-nypnib0h	193	42	.	.	.
cord-021419-nypnib0h	194	1	According	accord	VBG
cord-021419-nypnib0h	194	2	to	to	IN
cord-021419-nypnib0h	194	3	the	the	DT
cord-021419-nypnib0h	194	4	literature	literature	NN
cord-021419-nypnib0h	194	5	data	datum	NNS
cord-021419-nypnib0h	194	6	,	,	,
cord-021419-nypnib0h	194	7	a	a	DT
cord-021419-nypnib0h	194	8	number	number	NN
cord-021419-nypnib0h	194	9	of	of	IN
cord-021419-nypnib0h	194	10	semi	semi	JJ
cord-021419-nypnib0h	194	11	-	-	JJ
cord-021419-nypnib0h	194	12	synthetic	synthetic	JJ
cord-021419-nypnib0h	194	13	derivatives	derivative	NNS
cord-021419-nypnib0h	194	14	of	of	IN
cord-021419-nypnib0h	194	15	a	a	DT
cord-021419-nypnib0h	194	16	new	new	JJ
cord-021419-nypnib0h	194	17	generation	generation	NN
cord-021419-nypnib0h	194	18	were	be	VBD
cord-021419-nypnib0h	194	19	synthesized	synthesize	VBN
cord-021419-nypnib0h	194	20	based	base	VBN
cord-021419-nypnib0h	194	21	on	on	IN
cord-021419-nypnib0h	194	22	aminoglycosides	aminoglycoside	NNS
cord-021419-nypnib0h	194	23	.	.	.
cord-021419-nypnib0h	195	1	33	33	CD
cord-021419-nypnib0h	196	1	Various	various	JJ
cord-021419-nypnib0h	196	2	heterodimeric	heterodimeric	NN
cord-021419-nypnib0h	196	3	aminoglycoside	aminoglycoside	NN
cord-021419-nypnib0h	196	4	conjugates	conjugate	NNS
cord-021419-nypnib0h	196	5	with	with	IN
cord-021419-nypnib0h	196	6	other	other	JJ
cord-021419-nypnib0h	196	7	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	196	8	were	be	VBD
cord-021419-nypnib0h	196	9	reported	report	VBN
cord-021419-nypnib0h	196	10	,	,	,
cord-021419-nypnib0h	196	11	and	and	CC
cord-021419-nypnib0h	196	12	some	some	DT
cord-021419-nypnib0h	196	13	of	of	IN
cord-021419-nypnib0h	196	14	them	-PRON-	PRP
cord-021419-nypnib0h	196	15	are	be	VBP
cord-021419-nypnib0h	196	16	used	use	VBN
cord-021419-nypnib0h	196	17	in	in	IN
cord-021419-nypnib0h	196	18	medicine	medicine	NN
cord-021419-nypnib0h	196	19	.	.	.
cord-021419-nypnib0h	197	1	28	28	CD
cord-021419-nypnib0h	197	2	,	,	,
cord-021419-nypnib0h	197	3	29	29	CD
cord-021419-nypnib0h	198	1	The	the	DT
cord-021419-nypnib0h	198	2	synthesis	synthesis	NN
cord-021419-nypnib0h	198	3	of	of	IN
cord-021419-nypnib0h	198	4	hybrid	hybrid	JJ
cord-021419-nypnib0h	198	5	kanamycin	kanamycin	NNP
cord-021419-nypnib0h	198	6	A	a	DT
cord-021419-nypnib0h	198	7	conjugates	conjugate	NNS
cord-021419-nypnib0h	198	8	with	with	IN
cord-021419-nypnib0h	198	9	glycopeptides	glycopeptides	NNP
cord-021419-nypnib0h	198	10	1	1	CD
cord-021419-nypnib0h	198	11	and	and	CC
cord-021419-nypnib0h	198	12	3	3	CD
cord-021419-nypnib0h	198	13	was	be	VBD
cord-021419-nypnib0h	198	14	described	describe	VBN
cord-021419-nypnib0h	198	15	for	for	IN
cord-021419-nypnib0h	198	16	the	the	DT
cord-021419-nypnib0h	198	17	first	first	JJ
cord-021419-nypnib0h	198	18	time	time	NN
cord-021419-nypnib0h	198	19	in	in	IN
cord-021419-nypnib0h	198	20	our	-PRON-	PRP$
cord-021419-nypnib0h	198	21	publication	publication	NN
cord-021419-nypnib0h	198	22	.	.	.
cord-021419-nypnib0h	199	1	34	34	CD
cord-021419-nypnib0h	199	2	Kanamycin	Kanamycin	NNP
cord-021419-nypnib0h	199	3	A	A	NNP
cord-021419-nypnib0h	199	4	(	(	-LRB-
cord-021419-nypnib0h	199	5	26a	26a	NNS
cord-021419-nypnib0h	199	6	)	)	-RRB-
cord-021419-nypnib0h	199	7	was	be	VBD
cord-021419-nypnib0h	199	8	conjugated	conjugate	VBN
cord-021419-nypnib0h	199	9	with	with	IN
cord-021419-nypnib0h	199	10	compounds	compound	NNS
cord-021419-nypnib0h	199	11	1	1	CD
cord-021419-nypnib0h	199	12	or	or	CC
cord-021419-nypnib0h	199	13	3	3	CD
cord-021419-nypnib0h	199	14	via	via	IN
cord-021419-nypnib0h	199	15	an	an	DT
cord-021419-nypnib0h	199	16	amino	amino	NN
cord-021419-nypnib0h	199	17	group	group	NN
cord-021419-nypnib0h	199	18	of	of	IN
cord-021419-nypnib0h	199	19	the	the	DT
cord-021419-nypnib0h	199	20	antibiotic	antibiotic	NN
cord-021419-nypnib0h	199	21	at	at	IN
cord-021419-nypnib0h	199	22	the	the	DT
cord-021419-nypnib0h	199	23	1	1	CD
cord-021419-nypnib0h	199	24	position	position	NN
cord-021419-nypnib0h	199	25	of	of	IN
cord-021419-nypnib0h	199	26	2-deoxy	2-deoxy	CD
cord-021419-nypnib0h	199	27	-	-	HYPH
cord-021419-nypnib0h	199	28	D	D	NNP
cord-021419-nypnib0h	199	29	-	-	HYPH
cord-021419-nypnib0h	199	30	streptamine	streptamine	NN
cord-021419-nypnib0h	199	31	.	.	.
cord-021419-nypnib0h	200	1	The	the	DT
cord-021419-nypnib0h	200	2	acylation	acylation	NN
cord-021419-nypnib0h	200	3	of	of	IN
cord-021419-nypnib0h	200	4	this	this	DT
cord-021419-nypnib0h	200	5	amino	amino	NN
cord-021419-nypnib0h	200	6	group	group	NN
cord-021419-nypnib0h	200	7	is	be	VBZ
cord-021419-nypnib0h	200	8	known	know	VBN
cord-021419-nypnib0h	200	9	to	to	TO
cord-021419-nypnib0h	200	10	reduce	reduce	VB
cord-021419-nypnib0h	200	11	the	the	DT
cord-021419-nypnib0h	200	12	risk	risk	NN
cord-021419-nypnib0h	200	13	of	of	IN
cord-021419-nypnib0h	200	14	the	the	DT
cord-021419-nypnib0h	200	15	development	development	NN
cord-021419-nypnib0h	200	16	of	of	IN
cord-021419-nypnib0h	200	17	resistance	resistance	NN
cord-021419-nypnib0h	200	18	,	,	,
cord-021419-nypnib0h	200	19	because	because	IN
cord-021419-nypnib0h	200	20	it	-PRON-	PRP
cord-021419-nypnib0h	200	21	prevents	prevent	VBZ
cord-021419-nypnib0h	200	22	deactivation	deactivation	NN
cord-021419-nypnib0h	200	23	of	of	IN
cord-021419-nypnib0h	200	24	the	the	DT
cord-021419-nypnib0h	200	25	antibiotic	antibiotic	NN
cord-021419-nypnib0h	200	26	by	by	IN
cord-021419-nypnib0h	200	27	enzymes	enzyme	NNS
cord-021419-nypnib0h	200	28	.	.	.
cord-021419-nypnib0h	201	1	The	the	DT
cord-021419-nypnib0h	201	2	amino	amino	NN
cord-021419-nypnib0h	201	3	group	group	NN
cord-021419-nypnib0h	201	4	at	at	IN
cord-021419-nypnib0h	201	5	the	the	DT
cord-021419-nypnib0h	201	6	3	3	CD
cord-021419-nypnib0h	201	7	position	position	NN
cord-021419-nypnib0h	201	8	of	of	IN
cord-021419-nypnib0h	201	9	2-deoxy	2-deoxy	CD
cord-021419-nypnib0h	201	10	-	-	HYPH
cord-021419-nypnib0h	201	11	Dstreptamine	Dstreptamine	NNP
cord-021419-nypnib0h	201	12	and	and	CC
cord-021419-nypnib0h	201	13	the	the	DT
cord-021419-nypnib0h	201	14	6	6	CD
cord-021419-nypnib0h	201	15	H	h	NN
cord-021419-nypnib0h	201	16	-amino	-amino	HYPH
cord-021419-nypnib0h	201	17	group	group	NN
cord-021419-nypnib0h	201	18	of	of	IN
cord-021419-nypnib0h	201	19	6	6	CD
cord-021419-nypnib0h	201	20	H	h	NN
cord-021419-nypnib0h	201	21	-deoxy-6	-deoxy-6	HYPH
cord-021419-nypnib0h	201	22	H	H	NNP
cord-021419-nypnib0h	201	23	-amino	-amino	:
cord-021419-nypnib0h	201	24	-	-	HYPH
cord-021419-nypnib0h	201	25	D	d	NN
cord-021419-nypnib0h	201	26	-	-	HYPH
cord-021419-nypnib0h	201	27	glucopyranose	glucopyranose	NN
cord-021419-nypnib0h	201	28	of	of	IN
cord-021419-nypnib0h	201	29	aminoglycoside	aminoglycoside	NNP
cord-021419-nypnib0h	201	30	26a	26a	NNS
cord-021419-nypnib0h	201	31	were	be	VBD
cord-021419-nypnib0h	201	32	protected	protect	VBN
cord-021419-nypnib0h	201	33	by	by	IN
cord-021419-nypnib0h	201	34	the	the	DT
cord-021419-nypnib0h	201	35	benzyloxycarbonyl	benzyloxycarbonyl	NNP
cord-021419-nypnib0h	201	36	group	group	NN
cord-021419-nypnib0h	201	37	(	(	-LRB-
cord-021419-nypnib0h	201	38	Cbz	Cbz	NNP
cord-021419-nypnib0h	201	39	)	)	-RRB-
cord-021419-nypnib0h	201	40	.	.	.
cord-021419-nypnib0h	202	1	3,6	3,6	CD
cord-021419-nypnib0h	202	2	H	h	NN
cord-021419-nypnib0h	203	1	-Bis-(Cbz)-kanamycin	-Bis-(Cbz)-kanamycin	:
cord-021419-nypnib0h	203	2	A	A	NNP
cord-021419-nypnib0h	203	3	(	(	-LRB-
cord-021419-nypnib0h	203	4	26b	26b	CD
cord-021419-nypnib0h	203	5	)	)	-RRB-
cord-021419-nypnib0h	203	6	was	be	VBD
cord-021419-nypnib0h	203	7	synthesized	synthesize	VBN
cord-021419-nypnib0h	203	8	by	by	IN
cord-021419-nypnib0h	203	9	the	the	DT
cord-021419-nypnib0h	203	10	reaction	reaction	NN
cord-021419-nypnib0h	203	11	of	of	IN
cord-021419-nypnib0h	203	12	the	the	DT
cord-021419-nypnib0h	203	13	zinc	zinc	NN
cord-021419-nypnib0h	203	14	complex	complex	NN
cord-021419-nypnib0h	203	15	of	of	IN
cord-021419-nypnib0h	203	16	compound	compound	NN
cord-021419-nypnib0h	203	17	26a	26a	NNS
cord-021419-nypnib0h	203	18	with	with	IN
cord-021419-nypnib0h	203	19	CbzCl	CbzCl	NNP
cord-021419-nypnib0h	203	20	in	in	IN
cord-021419-nypnib0h	203	21	the	the	DT
cord-021419-nypnib0h	203	22	presence	presence	NN
cord-021419-nypnib0h	203	23	of	of	IN
cord-021419-nypnib0h	203	24	a	a	DT
cord-021419-nypnib0h	203	25	base	base	NN
cord-021419-nypnib0h	203	26	(	(	-LRB-
cord-021419-nypnib0h	203	27	Et	Et	NNP
cord-021419-nypnib0h	203	28	3	3	CD
cord-021419-nypnib0h	203	29	N	N	NNP
cord-021419-nypnib0h	203	30	)	)	-RRB-
cord-021419-nypnib0h	203	31	using	use	VBG
cord-021419-nypnib0h	203	32	a	a	DT
cord-021419-nypnib0h	203	33	modified	modify	VBN
cord-021419-nypnib0h	203	34	method	method	NN
cord-021419-nypnib0h	203	35	35	35	CD
cord-021419-nypnib0h	203	36	(	(	-LRB-
cord-021419-nypnib0h	203	37	Scheme	scheme	NN
cord-021419-nypnib0h	203	38	8)	8)	NN
cord-021419-nypnib0h	203	39	.	.	.
cord-021419-nypnib0h	204	1	(	(	-LRB-
cord-021419-nypnib0h	204	2	MIC	mic	NN
cord-021419-nypnib0h	204	3	*	*	NFP
cord-021419-nypnib0h	205	1	2	2	LS
cord-021419-nypnib0h	205	2	±	±	CD
cord-021419-nypnib0h	205	3	4	4	CD
cord-021419-nypnib0h	206	1	mg	mg	NN
cord-021419-nypnib0h	206	2	mL	mL	NNP
cord-021419-nypnib0h	206	3	71	71	CD
cord-021419-nypnib0h	206	4	for	for	IN
cord-021419-nypnib0h	206	5	compounds	compound	NNS
cord-021419-nypnib0h	206	6	27	27	CD
cord-021419-nypnib0h	206	7	,	,	,
cord-021419-nypnib0h	206	8	28a	28a	NNS
cord-021419-nypnib0h	206	9	,	,	,
cord-021419-nypnib0h	206	10	b	b	LS
cord-021419-nypnib0h	206	11	)	)	-RRB-
cord-021419-nypnib0h	206	12	and	and	CC
cord-021419-nypnib0h	206	13	VRE	VRE	NNP
cord-021419-nypnib0h	206	14	stains	stain	NNS
cord-021419-nypnib0h	206	15	(	(	-LRB-
cord-021419-nypnib0h	206	16	MIC	MIC	NNP
cord-021419-nypnib0h	206	17	=	=	SYM
cord-021419-nypnib0h	206	18	8	8	CD
cord-021419-nypnib0h	206	19	mg	mg	NNP
cord-021419-nypnib0h	206	20	mL	mL	NNP
cord-021419-nypnib0h	206	21	71	71	CD
cord-021419-nypnib0h	206	22	for	for	IN
cord-021419-nypnib0h	206	23	compound	compound	NN
cord-021419-nypnib0h	206	24	28a	28a	NNS
cord-021419-nypnib0h	206	25	)	)	-RRB-
cord-021419-nypnib0h	206	26	.	.	.
cord-021419-nypnib0h	207	1	34	34	CD
cord-021419-nypnib0h	208	1	Based	base	VBN
cord-021419-nypnib0h	208	2	on	on	IN
cord-021419-nypnib0h	208	3	the	the	DT
cord-021419-nypnib0h	208	4	results	result	NNS
cord-021419-nypnib0h	208	5	of	of	IN
cord-021419-nypnib0h	208	6	these	these	DT
cord-021419-nypnib0h	208	7	studies	study	NNS
cord-021419-nypnib0h	208	8	,	,	,
cord-021419-nypnib0h	208	9	methods	method	NNS
cord-021419-nypnib0h	208	10	were	be	VBD
cord-021419-nypnib0h	208	11	developed	develop	VBN
cord-021419-nypnib0h	208	12	for	for	IN
cord-021419-nypnib0h	208	13	the	the	DT
cord-021419-nypnib0h	208	14	selective	selective	JJ
cord-021419-nypnib0h	208	15	introduction	introduction	NN
cord-021419-nypnib0h	208	16	of	of	IN
cord-021419-nypnib0h	208	17	functional	functional	JJ
cord-021419-nypnib0h	208	18	groups	group	NNS
cord-021419-nypnib0h	208	19	at	at	IN
cord-021419-nypnib0h	208	20	the	the	DT
cord-021419-nypnib0h	208	21	amino	amino	NN
cord-021419-nypnib0h	208	22	sugar	sugar	NN
cord-021419-nypnib0h	208	23	amino	amino	NNS
cord-021419-nypnib0h	208	24	group	group	NN
cord-021419-nypnib0h	208	25	of	of	IN
cord-021419-nypnib0h	208	26	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	208	27	(	(	-LRB-
cord-021419-nypnib0h	208	28	1	1	CD
cord-021419-nypnib0h	208	29	)	)	-RRB-
cord-021419-nypnib0h	208	30	or	or	CC
cord-021419-nypnib0h	208	31	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	208	32	(	(	-LRB-
cord-021419-nypnib0h	208	33	3	3	CD
cord-021419-nypnib0h	208	34	)	)	-RRB-
cord-021419-nypnib0h	208	35	,	,	,
cord-021419-nypnib0h	208	36	with	with	IN
cord-021419-nypnib0h	208	37	the	the	DT
cord-021419-nypnib0h	208	38	terminal	terminal	JJ
cord-021419-nypnib0h	208	39	methylamino	methylamino	NNP
cord-021419-nypnib0h	208	40	group	group	NN
cord-021419-nypnib0h	208	41	of	of	IN
cord-021419-nypnib0h	208	42	the	the	DT
cord-021419-nypnib0h	208	43	peptide	peptide	NN
cord-021419-nypnib0h	208	44	core	core	NN
cord-021419-nypnib0h	208	45	of	of	IN
cord-021419-nypnib0h	208	46	the	the	DT
cord-021419-nypnib0h	208	47	antibiotic	antibiotic	NN
cord-021419-nypnib0h	208	48	remaining	remain	VBG
cord-021419-nypnib0h	208	49	intact	intact	JJ
cord-021419-nypnib0h	208	50	.	.	.
cord-021419-nypnib0h	209	1	17	17	CD
cord-021419-nypnib0h	210	1	The	the	DT
cord-021419-nypnib0h	210	2	amidation	amidation	NN
cord-021419-nypnib0h	210	3	of	of	IN
cord-021419-nypnib0h	210	4	the	the	DT
cord-021419-nypnib0h	210	5	terminal	terminal	JJ
cord-021419-nypnib0h	210	6	carboxyl	carboxyl	NN
cord-021419-nypnib0h	210	7	group	group	NN
cord-021419-nypnib0h	210	8	of	of	IN
cord-021419-nypnib0h	210	9	these	these	DT
cord-021419-nypnib0h	210	10	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	210	11	with	with	IN
cord-021419-nypnib0h	210	12	various	various	JJ
cord-021419-nypnib0h	210	13	amines	amine	NNS
cord-021419-nypnib0h	210	14	,	,	,
cord-021419-nypnib0h	210	15	including	include	VBG
cord-021419-nypnib0h	210	16	amines	amine	NNS
cord-021419-nypnib0h	210	17	with	with	IN
cord-021419-nypnib0h	210	18	bulky	bulky	JJ
cord-021419-nypnib0h	210	19	substituents	substituent	NNS
cord-021419-nypnib0h	210	20	,	,	,
cord-021419-nypnib0h	210	21	was	be	VBD
cord-021419-nypnib0h	210	22	studied	study	VBN
cord-021419-nypnib0h	210	23	in	in	IN
cord-021419-nypnib0h	210	24	detail	detail	NN
cord-021419-nypnib0h	210	25	.	.	.
cord-021419-nypnib0h	211	1	12	12	CD
cord-021419-nypnib0h	211	2	,	,	,
cord-021419-nypnib0h	211	3	13	13	CD
cord-021419-nypnib0h	211	4	,	,	,
cord-021419-nypnib0h	211	5	15	15	CD
cord-021419-nypnib0h	212	1	An	an	DT
cord-021419-nypnib0h	212	2	unusual	unusual	JJ
cord-021419-nypnib0h	212	3	byproduct	byproduct	NN
cord-021419-nypnib0h	212	4	of	of	IN
cord-021419-nypnib0h	212	5	amidation	amidation	NN
cord-021419-nypnib0h	212	6	(	(	-LRB-
cord-021419-nypnib0h	212	7	previously	previously	RB
cord-021419-nypnib0h	212	8	unknown	unknown	JJ
cord-021419-nypnib0h	212	9	for	for	IN
cord-021419-nypnib0h	212	10	these	these	DT
cord-021419-nypnib0h	212	11	classes	class	NNS
cord-021419-nypnib0h	212	12	of	of	IN
cord-021419-nypnib0h	212	13	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	212	14	)	)	-RRB-
cord-021419-nypnib0h	212	15	was	be	VBD
cord-021419-nypnib0h	212	16	isolated	isolate	VBN
cord-021419-nypnib0h	212	17	,	,	,
cord-021419-nypnib0h	212	18	and	and	CC
cord-021419-nypnib0h	212	19	the	the	DT
cord-021419-nypnib0h	212	20	optimal	optimal	JJ
cord-021419-nypnib0h	212	21	conditions	condition	NNS
cord-021419-nypnib0h	212	22	were	be	VBD
cord-021419-nypnib0h	212	23	found	find	VBN
cord-021419-nypnib0h	212	24	for	for	IN
cord-021419-nypnib0h	212	25	the	the	DT
cord-021419-nypnib0h	212	26	amidation	amidation	NN
cord-021419-nypnib0h	212	27	providing	provide	VBG
cord-021419-nypnib0h	212	28	the	the	DT
cord-021419-nypnib0h	212	29	target	target	NN
cord-021419-nypnib0h	212	30	products	product	NNS
cord-021419-nypnib0h	212	31	in	in	IN
cord-021419-nypnib0h	212	32	high	high	JJ
cord-021419-nypnib0h	212	33	yields	yield	NNS
cord-021419-nypnib0h	212	34	.	.	.
cord-021419-nypnib0h	213	1	15	15	CD
cord-021419-nypnib0h	213	2	,	,	,
cord-021419-nypnib0h	213	3	16	16	CD
cord-021419-nypnib0h	214	1	The	the	DT
cord-021419-nypnib0h	214	2	introduction	introduction	NN
cord-021419-nypnib0h	214	3	of	of	IN
cord-021419-nypnib0h	214	4	various	various	JJ
cord-021419-nypnib0h	214	5	groups	group	NNS
cord-021419-nypnib0h	214	6	into	into	IN
cord-021419-nypnib0h	214	7	glycopeptides	glycopeptide	NNS
cord-021419-nypnib0h	214	8	at	at	IN
cord-021419-nypnib0h	214	9	certain	certain	JJ
cord-021419-nypnib0h	214	10	positions	position	NNS
cord-021419-nypnib0h	214	11	of	of	IN
cord-021419-nypnib0h	214	12	the	the	DT
cord-021419-nypnib0h	214	13	molecule	molecule	NN
cord-021419-nypnib0h	214	14	can	can	MD
cord-021419-nypnib0h	214	15	give	give	VB
cord-021419-nypnib0h	214	16	new	new	JJ
cord-021419-nypnib0h	214	17	derivatives	derivative	NNS
cord-021419-nypnib0h	214	18	active	active	JJ
cord-021419-nypnib0h	214	19	against	against	IN
cord-021419-nypnib0h	214	20	bacteria	bacteria	NNS
cord-021419-nypnib0h	214	21	that	that	WDT
cord-021419-nypnib0h	214	22	are	be	VBP
cord-021419-nypnib0h	214	23	resistant	resistant	JJ
cord-021419-nypnib0h	214	24	to	to	IN
cord-021419-nypnib0h	214	25	the	the	DT
cord-021419-nypnib0h	214	26	initial	initial	JJ
cord-021419-nypnib0h	214	27	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	214	28	Ð	Ð	NNP
cord-021419-nypnib0h	214	29	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	214	30	-	-	HYPH
cord-021419-nypnib0h	214	31	resistant	resistant	JJ
cord-021419-nypnib0h	214	32	enterococci	enterococci	NNS
cord-021419-nypnib0h	214	33	.	.	.
cord-021419-nypnib0h	215	1	5	5	CD
cord-021419-nypnib0h	215	2	,	,	,
cord-021419-nypnib0h	215	3	10	10	CD
cord-021419-nypnib0h	215	4	This	this	DT
cord-021419-nypnib0h	215	5	resulted	result	VBD
cord-021419-nypnib0h	215	6	in	in	IN
cord-021419-nypnib0h	215	7	the	the	DT
cord-021419-nypnib0h	215	8	discovery	discovery	NN
cord-021419-nypnib0h	215	9	of	of	IN
cord-021419-nypnib0h	215	10	compounds	compound	NNS
cord-021419-nypnib0h	215	11	exhibiting	exhibit	VBG
cord-021419-nypnib0h	215	12	high	high	JJ
cord-021419-nypnib0h	215	13	activity	activity	NN
cord-021419-nypnib0h	215	14	against	against	IN
cord-021419-nypnib0h	215	15	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	215	16	-	-	HYPH
cord-021419-nypnib0h	215	17	resistant	resistant	JJ
cord-021419-nypnib0h	215	18	enterococci	enterococci	NNS
cord-021419-nypnib0h	215	19	(	(	-LRB-
cord-021419-nypnib0h	215	20	MIC	mic	NN
cord-021419-nypnib0h	215	21	=	=	NFP
cord-021419-nypnib0h	216	1	2	2	LS
cord-021419-nypnib0h	216	2	±	±	CD
cord-021419-nypnib0h	216	3	8	8	CD
cord-021419-nypnib0h	217	1	mg	mg	NN
cord-021419-nypnib0h	217	2	mL	mL	NNP
cord-021419-nypnib0h	217	3	71	71	CD
cord-021419-nypnib0h	217	4	)	)	-RRB-
cord-021419-nypnib0h	217	5	and	and	CC
cord-021419-nypnib0h	217	6	Staphylococcus	Staphylococcus	NNP
cord-021419-nypnib0h	217	7	aureus	aureus	NN
cord-021419-nypnib0h	217	8	with	with	IN
cord-021419-nypnib0h	217	9	intermediate	intermediate	JJ
cord-021419-nypnib0h	217	10	resistance	resistance	NN
cord-021419-nypnib0h	217	11	to	to	IN
cord-021419-nypnib0h	217	12	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	217	13	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	217	14	(	(	-LRB-
cord-021419-nypnib0h	217	15	MIC	mic	NN
cord-021419-nypnib0h	217	16	=	=	SYM
cord-021419-nypnib0h	217	17	1	1	CD
cord-021419-nypnib0h	218	1	±	±	NNP
cord-021419-nypnib0h	218	2	2	2	CD
cord-021419-nypnib0h	219	1	mg	mg	NN
cord-021419-nypnib0h	219	2	mL	mL	NNP
cord-021419-nypnib0h	219	3	71	71	CD
cord-021419-nypnib0h	219	4	)	)	-RRB-
cord-021419-nypnib0h	219	5	.	.	.
cord-021419-nypnib0h	220	1	Generally	generally	RB
cord-021419-nypnib0h	220	2	,	,	,
cord-021419-nypnib0h	220	3	eremomycin	eremomycin	NN
cord-021419-nypnib0h	220	4	derivatives	derivative	NNS
cord-021419-nypnib0h	220	5	possess	possess	VBP
cord-021419-nypnib0h	220	6	higher	high	JJR
cord-021419-nypnib0h	220	7	in	in	IN
cord-021419-nypnib0h	220	8	vitro	vitro	FW
cord-021419-nypnib0h	220	9	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	220	10	activity	activity	NN
cord-021419-nypnib0h	220	11	than	than	IN
cord-021419-nypnib0h	220	12	analogous	analogous	JJ
cord-021419-nypnib0h	220	13	vancomycin	vancomycin	NN
cord-021419-nypnib0h	220	14	derivatives	derivative	NNS
cord-021419-nypnib0h	220	15	and	and	CC
cord-021419-nypnib0h	220	16	show	show	VB
cord-021419-nypnib0h	220	17	significant	significant	JJ
cord-021419-nypnib0h	220	18	advantages	advantage	NNS
cord-021419-nypnib0h	220	19	over	over	IN
cord-021419-nypnib0h	220	20	vancomycin	vancomycin	NN
cord-021419-nypnib0h	220	21	in	in	IN
cord-021419-nypnib0h	220	22	the	the	DT
cord-021419-nypnib0h	220	23	treatment	treatment	NN
cord-021419-nypnib0h	220	24	of	of	IN
cord-021419-nypnib0h	220	25	animals	animal	NNS
cord-021419-nypnib0h	220	26	in	in	IN
cord-021419-nypnib0h	220	27	a	a	DT
cord-021419-nypnib0h	220	28	mouse	mouse	NN
cord-021419-nypnib0h	220	29	model	model	NN
cord-021419-nypnib0h	220	30	of	of	IN
cord-021419-nypnib0h	220	31	staphylococcal	staphylococcal	JJ
cord-021419-nypnib0h	220	32	sepsis	sepsis	NN
cord-021419-nypnib0h	220	33	.	.	.
cord-021419-nypnib0h	221	1	10	10	CD
cord-021419-nypnib0h	221	2	,	,	,
cord-021419-nypnib0h	221	3	13	13	CD
cord-021419-nypnib0h	221	4	Conditions	condition	NNS
cord-021419-nypnib0h	221	5	were	be	VBD
cord-021419-nypnib0h	221	6	found	find	VBN
cord-021419-nypnib0h	221	7	for	for	IN
cord-021419-nypnib0h	221	8	the	the	DT
cord-021419-nypnib0h	221	9	selective	selective	JJ
cord-021419-nypnib0h	221	10	introduction	introduction	NN
cord-021419-nypnib0h	221	11	of	of	IN
cord-021419-nypnib0h	221	12	isotopic	isotopic	JJ
cord-021419-nypnib0h	221	13	labels	label	NNS
cord-021419-nypnib0h	221	14	at	at	IN
cord-021419-nypnib0h	221	15	both	both	CC
cord-021419-nypnib0h	221	16	the	the	DT
cord-021419-nypnib0h	221	17	terminal	terminal	JJ
cord-021419-nypnib0h	221	18	carboxyl	carboxyl	NN
cord-021419-nypnib0h	221	19	group	group	NN
cord-021419-nypnib0h	221	20	and	and	CC
cord-021419-nypnib0h	221	21	the	the	DT
cord-021419-nypnib0h	221	22	asparagine	asparagine	NN
cord-021419-nypnib0h	221	23	residue	residue	NN
cord-021419-nypnib0h	221	24	(	(	-LRB-
cord-021419-nypnib0h	221	25	AA3	AA3	NNP
cord-021419-nypnib0h	221	26	)	)	-RRB-
cord-021419-nypnib0h	221	27	of	of	IN
cord-021419-nypnib0h	221	28	the	the	DT
cord-021419-nypnib0h	221	29	peptide	peptide	NN
cord-021419-nypnib0h	221	30	core	core	NN
cord-021419-nypnib0h	221	31	of	of	IN
cord-021419-nypnib0h	221	32	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	221	33	,	,	,
cord-021419-nypnib0h	221	34	with	with	IN
cord-021419-nypnib0h	221	35	carbohydrate	carbohydrate	NN
cord-021419-nypnib0h	221	36	moieties	moiety	NNS
cord-021419-nypnib0h	221	37	and	and	CC
cord-021419-nypnib0h	221	38	other	other	JJ
cord-021419-nypnib0h	221	39	labile	labile	JJ
cord-021419-nypnib0h	221	40	functional	functional	JJ
cord-021419-nypnib0h	221	41	groups	group	NNS
cord-021419-nypnib0h	221	42	remaining	remain	VBG
cord-021419-nypnib0h	221	43	intact	intact	JJ
cord-021419-nypnib0h	221	44	.	.	.
cord-021419-nypnib0h	222	1	19	19	CD
cord-021419-nypnib0h	223	1	The	the	DT
cord-021419-nypnib0h	223	2	investigation	investigation	NN
cord-021419-nypnib0h	223	3	of	of	IN
cord-021419-nypnib0h	223	4	interactions	interaction	NNS
cord-021419-nypnib0h	223	5	of	of	IN
cord-021419-nypnib0h	223	6	these	these	DT
cord-021419-nypnib0h	223	7	compounds	compound	NNS
cord-021419-nypnib0h	223	8	with	with	IN
cord-021419-nypnib0h	223	9	native	native	JJ
cord-021419-nypnib0h	223	10	cells	cell	NNS
cord-021419-nypnib0h	223	11	of	of	IN
cord-021419-nypnib0h	223	12	Gram	gram	NN
cord-021419-nypnib0h	223	13	-	-	HYPH
cord-021419-nypnib0h	223	14	positive	positive	JJ
cord-021419-nypnib0h	223	15	bacteria	bacteria	NNS
cord-021419-nypnib0h	223	16	by	by	IN
cord-021419-nypnib0h	223	17	the	the	DT
cord-021419-nypnib0h	223	18	REDOR	REDOR	NNP
cord-021419-nypnib0h	223	19	technique	technique	NN
cord-021419-nypnib0h	223	20	confirmed	confirm	VBD
cord-021419-nypnib0h	223	21	the	the	DT
cord-021419-nypnib0h	223	22	mechanisms	mechanism	NNS
cord-021419-nypnib0h	223	23	of	of	IN
cord-021419-nypnib0h	223	24	action	action	NN
cord-021419-nypnib0h	223	25	of	of	IN
cord-021419-nypnib0h	223	26	this	this	DT
cord-021419-nypnib0h	223	27	group	group	NN
cord-021419-nypnib0h	223	28	of	of	IN
cord-021419-nypnib0h	223	29	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	223	30	proposed	propose	VBN
cord-021419-nypnib0h	223	31	in	in	IN
cord-021419-nypnib0h	223	32	our	-PRON-	PRP$
cord-021419-nypnib0h	223	33	previous	previous	JJ
cord-021419-nypnib0h	223	34	studies	study	NNS
cord-021419-nypnib0h	223	35	.	.	.
cord-021419-nypnib0h	224	1	20	20	CD
cord-021419-nypnib0h	224	2	,	,	,
cord-021419-nypnib0h	224	3	21	21	CD
cord-021419-nypnib0h	224	4	Modifications	modification	NNS
cord-021419-nypnib0h	224	5	of	of	IN
cord-021419-nypnib0h	224	6	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	224	7	aglycones	aglycone	NNS
cord-021419-nypnib0h	224	8	at	at	IN
cord-021419-nypnib0h	224	9	the	the	DT
cord-021419-nypnib0h	224	10	carboxyl	carboxyl	NN
cord-021419-nypnib0h	224	11	and(or	and(or	NNP
cord-021419-nypnib0h	224	12	)	)	-RRB-
cord-021419-nypnib0h	225	1	amino	amino	NNP
cord-021419-nypnib0h	225	2	group	group	NN
cord-021419-nypnib0h	225	3	were	be	VBD
cord-021419-nypnib0h	225	4	performed	perform	VBN
cord-021419-nypnib0h	225	5	in	in	IN
cord-021419-nypnib0h	225	6	a	a	DT
cord-021419-nypnib0h	225	7	series	series	NN
cord-021419-nypnib0h	225	8	of	of	IN
cord-021419-nypnib0h	225	9	studies	study	NNS
cord-021419-nypnib0h	225	10	.	.	.
cord-021419-nypnib0h	226	1	22	22	CD
cord-021419-nypnib0h	226	2	±	±	CD
cord-021419-nypnib0h	226	3	25	25	CD
cord-021419-nypnib0h	227	1	This	this	DT
cord-021419-nypnib0h	227	2	resulted	result	VBD
cord-021419-nypnib0h	227	3	in	in	IN
cord-021419-nypnib0h	227	4	the	the	DT
cord-021419-nypnib0h	227	5	discovery	discovery	NN
cord-021419-nypnib0h	227	6	and	and	CC
cord-021419-nypnib0h	227	7	characterization	characterization	NN
cord-021419-nypnib0h	227	8	of	of	IN
cord-021419-nypnib0h	227	9	a	a	DT
cord-021419-nypnib0h	227	10	new	new	JJ
cord-021419-nypnib0h	227	11	class	class	NN
cord-021419-nypnib0h	227	12	of	of	IN
cord-021419-nypnib0h	227	13	polycyclic	polycyclic	NN
cord-021419-nypnib0h	227	14	peptides	peptide	NNS
cord-021419-nypnib0h	227	15	exhibiting	exhibit	VBG
cord-021419-nypnib0h	227	16	antiviral	antiviral	JJ
cord-021419-nypnib0h	227	17	activity	activity	NN
cord-021419-nypnib0h	227	18	at	at	IN
cord-021419-nypnib0h	227	19	micromolar	micromolar	JJ
cord-021419-nypnib0h	227	20	concentrations	concentration	NNS
cord-021419-nypnib0h	227	21	against	against	IN
cord-021419-nypnib0h	227	22	HIV-1	HIV-1	NNP
cord-021419-nypnib0h	227	23	and	and	CC
cord-021419-nypnib0h	227	24	HIV-2	HIV-2	NNP
cord-021419-nypnib0h	227	25	,	,	,
cord-021419-nypnib0h	227	26	as	as	RB
cord-021419-nypnib0h	227	27	well	well	RB
cord-021419-nypnib0h	227	28	as	as	IN
cord-021419-nypnib0h	227	29	against	against	IN
cord-021419-nypnib0h	227	30	the	the	DT
cord-021419-nypnib0h	227	31	enveloped	envelop	VBN
cord-021419-nypnib0h	227	32	viruses	virus	NNS
cord-021419-nypnib0h	227	33	HCV	HCV	NNP
cord-021419-nypnib0h	227	34	,	,	,
cord-021419-nypnib0h	227	35	DENV	DENV	NNP
cord-021419-nypnib0h	227	36	and	and	CC
cord-021419-nypnib0h	227	37	many	many	JJ
cord-021419-nypnib0h	227	38	other	other	JJ
cord-021419-nypnib0h	227	39	.	.	.
cord-021419-nypnib0h	228	1	22	22	CD
cord-021419-nypnib0h	228	2	±	±	CD
cord-021419-nypnib0h	228	3	26	26	CD
cord-021419-nypnib0h	229	1	The	the	DT
cord-021419-nypnib0h	229	2	correlation	correlation	NN
cord-021419-nypnib0h	229	3	between	between	IN
cord-021419-nypnib0h	229	4	antiviral	antiviral	JJ
cord-021419-nypnib0h	229	5	and	and	CC
cord-021419-nypnib0h	229	6	PK	PK	NNP
cord-021419-nypnib0h	229	7	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	229	8	activities	activity	NNS
cord-021419-nypnib0h	229	9	was	be	VBD
cord-021419-nypnib0h	229	10	established	establish	VBN
cord-021419-nypnib0h	229	11	for	for	IN
cord-021419-nypnib0h	229	12	a	a	DT
cord-021419-nypnib0h	229	13	class	class	NN
cord-021419-nypnib0h	229	14	of	of	IN
cord-021419-nypnib0h	229	15	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	229	16	derivatives	derivative	NNS
cord-021419-nypnib0h	229	17	of	of	IN
cord-021419-nypnib0h	229	18	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	229	19	aglycones	aglycones	NNP
cord-021419-nypnib0h	229	20	.	.	.
cord-021419-nypnib0h	230	1	27	27	CD
cord-021419-nypnib0h	231	1	The	the	DT
cord-021419-nypnib0h	231	2	first	first	JJ
cord-021419-nypnib0h	231	3	heterodimeric	heterodimeric	NNP
cord-021419-nypnib0h	231	4	conjugates	conjugate	NNS
cord-021419-nypnib0h	231	5	of	of	IN
cord-021419-nypnib0h	231	6	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	231	7	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	231	8	with	with	IN
cord-021419-nypnib0h	231	9	boroles	borole	NNS
cord-021419-nypnib0h	231	10	,	,	,
cord-021419-nypnib0h	231	11	31	31	CD
cord-021419-nypnib0h	231	12	,	,	,
cord-021419-nypnib0h	231	13	32	32	CD
cord-021419-nypnib0h	231	14	and	and	CC
cord-021419-nypnib0h	231	15	with	with	IN
cord-021419-nypnib0h	231	16	kanamycin	kanamycin	NNP
cord-021419-nypnib0h	231	17	A	A	NNP
cord-021419-nypnib0h	231	18	34	34	CD
cord-021419-nypnib0h	231	19	were	be	VBD
cord-021419-nypnib0h	231	20	synthesized	synthesize	VBN
cord-021419-nypnib0h	231	21	.	.	.
cord-021419-nypnib0h	232	1	The	the	DT
cord-021419-nypnib0h	232	2	conjugates	conjugate	NNS
cord-021419-nypnib0h	232	3	exhibit	exhibit	VBP
cord-021419-nypnib0h	232	4	activity	activity	NN
cord-021419-nypnib0h	232	5	against	against	IN
cord-021419-nypnib0h	232	6	resistant	resistant	JJ
cord-021419-nypnib0h	232	7	VRE	VRE	NNP
cord-021419-nypnib0h	232	8	and(or	and(or	NNP
cord-021419-nypnib0h	232	9	)	)	-RRB-
cord-021419-nypnib0h	232	10	VISA	visa	NN
cord-021419-nypnib0h	232	11	strains	strain	NNS
cord-021419-nypnib0h	232	12	.	.	.
cord-021419-nypnib0h	233	1	The	the	DT
cord-021419-nypnib0h	233	2	synthesis	synthesis	NN
cord-021419-nypnib0h	233	3	of	of	IN
cord-021419-nypnib0h	233	4	chimeric	chimeric	JJ
cord-021419-nypnib0h	233	5	(	(	-LRB-
cord-021419-nypnib0h	233	6	heterodimeric	heterodimeric	NNP
cord-021419-nypnib0h	233	7	)	)	-RRB-
cord-021419-nypnib0h	233	8	macrolide	macrolide	NN
cord-021419-nypnib0h	233	9	-	-	HYPH
cord-021419-nypnib0h	233	10	based	base	VBN
cord-021419-nypnib0h	233	11	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	233	12	is	be	VBZ
cord-021419-nypnib0h	233	13	a	a	DT
cord-021419-nypnib0h	233	14	promising	promising	JJ
cord-021419-nypnib0h	233	15	area	area	NN
cord-021419-nypnib0h	233	16	of	of	IN
cord-021419-nypnib0h	233	17	research	research	NN
cord-021419-nypnib0h	233	18	to	to	TO
cord-021419-nypnib0h	233	19	search	search	VB
cord-021419-nypnib0h	233	20	for	for	IN
cord-021419-nypnib0h	233	21	new	new	JJ
cord-021419-nypnib0h	233	22	antimicrobial	antimicrobial	JJ
cord-021419-nypnib0h	233	23	agents	agent	NNS
cord-021419-nypnib0h	233	24	.	.	.
cord-021419-nypnib0h	234	1	28	28	CD
cord-021419-nypnib0h	235	1	These	these	DT
cord-021419-nypnib0h	235	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	235	3	are	be	VBP
cord-021419-nypnib0h	235	4	among	among	IN
cord-021419-nypnib0h	235	5	the	the	DT
cord-021419-nypnib0h	235	6	most	most	RBS
cord-021419-nypnib0h	235	7	effective	effective	JJ
cord-021419-nypnib0h	235	8	broad	broad	JJ
cord-021419-nypnib0h	235	9	-	-	HYPH
cord-021419-nypnib0h	235	10	spectrum	spectrum	NN
cord-021419-nypnib0h	235	11	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	235	12	agents	agent	NNS
cord-021419-nypnib0h	235	13	.	.	.
cord-021419-nypnib0h	236	1	The	the	DT
cord-021419-nypnib0h	236	2	semi	semi	JJ
cord-021419-nypnib0h	236	3	-	-	JJ
cord-021419-nypnib0h	236	4	synthetic	synthetic	JJ
cord-021419-nypnib0h	236	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	236	6	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	236	7	(	(	-LRB-
cord-021419-nypnib0h	236	8	29	29	CD
cord-021419-nypnib0h	236	9	)	)	-RRB-
cord-021419-nypnib0h	236	10	and	and	CC
cord-021419-nypnib0h	236	11	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	236	12	(	(	-LRB-
cord-021419-nypnib0h	236	13	30	30	CD
cord-021419-nypnib0h	236	14	)	)	-RRB-
cord-021419-nypnib0h	236	15	are	be	VBP
cord-021419-nypnib0h	236	16	commonly	commonly	RB
cord-021419-nypnib0h	236	17	used	use	VBN
cord-021419-nypnib0h	236	18	in	in	IN
cord-021419-nypnib0h	236	19	medicine	medicine	NN
cord-021419-nypnib0h	236	20	for	for	IN
cord-021419-nypnib0h	236	21	the	the	DT
cord-021419-nypnib0h	236	22	treatment	treatment	NN
cord-021419-nypnib0h	236	23	of	of	IN
cord-021419-nypnib0h	236	24	various	various	JJ
cord-021419-nypnib0h	236	25	infectious	infectious	JJ
cord-021419-nypnib0h	236	26	diseases	disease	NNS
cord-021419-nypnib0h	236	27	caused	cause	VBN
cord-021419-nypnib0h	236	28	by	by	IN
cord-021419-nypnib0h	236	29	many	many	JJ
cord-021419-nypnib0h	236	30	Gram	gram	NN
cord-021419-nypnib0h	236	31	-	-	HYPH
cord-021419-nypnib0h	236	32	positive	positive	JJ
cord-021419-nypnib0h	236	33	and	and	CC
cord-021419-nypnib0h	236	34	Gram	gram	NN
cord-021419-nypnib0h	236	35	-	-	HYPH
cord-021419-nypnib0h	236	36	negative	negative	JJ
cord-021419-nypnib0h	236	37	bacteria	bacteria	NNS
cord-021419-nypnib0h	236	38	(	(	-LRB-
cord-021419-nypnib0h	236	39	Fig	Fig	NNP
cord-021419-nypnib0h	236	40	.	.	NNP
cord-021419-nypnib0h	236	41	4	4	CD
cord-021419-nypnib0h	236	42	)	)	-RRB-
cord-021419-nypnib0h	236	43	.	.	.
cord-021419-nypnib0h	237	1	Azithromycin	Azithromycin	NNP
cord-021419-nypnib0h	237	2	(	(	-LRB-
cord-021419-nypnib0h	237	3	30	30	CD
cord-021419-nypnib0h	237	4	)	)	-RRB-
cord-021419-nypnib0h	237	5	has	have	VBZ
cord-021419-nypnib0h	237	6	the	the	DT
cord-021419-nypnib0h	237	7	best	good	JJS
cord-021419-nypnib0h	237	8	pharmacological	pharmacological	JJ
cord-021419-nypnib0h	237	9	profile	profile	NN
cord-021419-nypnib0h	237	10	among	among	IN
cord-021419-nypnib0h	237	11	macrolide	macrolide	JJ
cord-021419-nypnib0h	237	12	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	237	13	.	.	.
cord-021419-nypnib0h	238	1	The	the	DT
cord-021419-nypnib0h	238	2	mechanism	mechanism	NN
cord-021419-nypnib0h	238	3	of	of	IN
cord-021419-nypnib0h	238	4	action	action	NN
cord-021419-nypnib0h	238	5	of	of	IN
cord-021419-nypnib0h	238	6	macrolides	macrolide	NNS
cord-021419-nypnib0h	238	7	is	be	VBZ
cord-021419-nypnib0h	238	8	based	base	VBN
cord-021419-nypnib0h	238	9	on	on	IN
cord-021419-nypnib0h	238	10	the	the	DT
cord-021419-nypnib0h	238	11	inhibition	inhibition	NN
cord-021419-nypnib0h	238	12	of	of	IN
cord-021419-nypnib0h	238	13	protein	protein	NN
cord-021419-nypnib0h	238	14	synthesis	synthesis	NN
cord-021419-nypnib0h	238	15	.	.	.
cord-021419-nypnib0h	239	1	The	the	DT
cord-021419-nypnib0h	239	2	target	target	NN
cord-021419-nypnib0h	239	3	of	of	IN
cord-021419-nypnib0h	239	4	macrolides	macrolide	NNS
cord-021419-nypnib0h	239	5	is	be	VBZ
cord-021419-nypnib0h	239	6	the	the	DT
cord-021419-nypnib0h	239	7	peptidyl	peptidyl	NNP
cord-021419-nypnib0h	239	8	transferase	transferase	NNP
cord-021419-nypnib0h	239	9	centre	centre	NN
cord-021419-nypnib0h	239	10	on	on	IN
cord-021419-nypnib0h	239	11	the	the	DT
cord-021419-nypnib0h	239	12	large	large	JJ
cord-021419-nypnib0h	239	13	50S	50s	CD
cord-021419-nypnib0h	239	14	subunit	subunit	NN
cord-021419-nypnib0h	239	15	of	of	IN
cord-021419-nypnib0h	239	16	bacterial	bacterial	JJ
cord-021419-nypnib0h	239	17	ribosome	ribosome	NN
cord-021419-nypnib0h	239	18	.	.	.
cord-021419-nypnib0h	240	1	However	however	RB
cord-021419-nypnib0h	240	2	,	,	,
cord-021419-nypnib0h	240	3	clarithromycinand	clarithromycinand	NNP
cord-021419-nypnib0h	240	4	azithromycin	azithromycin	NN
cord-021419-nypnib0h	240	5	-	-	HYPH
cord-021419-nypnib0h	240	6	resistant	resistant	JJ
cord-021419-nypnib0h	240	7	clinical	clinical	JJ
cord-021419-nypnib0h	240	8	isolates	isolate	NNS
cord-021419-nypnib0h	240	9	of	of	IN
cord-021419-nypnib0h	240	10	bacteria	bacteria	NNS
cord-021419-nypnib0h	240	11	were	be	VBD
cord-021419-nypnib0h	240	12	isolated	isolate	VBN
cord-021419-nypnib0h	240	13	.	.	.
cord-021419-nypnib0h	241	1	36	36	CD
cord-021419-nypnib0h	241	2	Researchers	researcher	NNS
cord-021419-nypnib0h	241	3	at	at	IN
cord-021419-nypnib0h	241	4	the	the	DT
cord-021419-nypnib0h	241	5	Gause	Gause	NNP
cord-021419-nypnib0h	241	6	Institute	Institute	NNP
cord-021419-nypnib0h	241	7	of	of	IN
cord-021419-nypnib0h	241	8	New	New	NNP
cord-021419-nypnib0h	241	9	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	241	10	have	have	VBP
cord-021419-nypnib0h	241	11	developed	develop	VBN
cord-021419-nypnib0h	241	12	methods	method	NNS
cord-021419-nypnib0h	241	13	for	for	IN
cord-021419-nypnib0h	241	14	the	the	DT
cord-021419-nypnib0h	241	15	conjugation	conjugation	NN
cord-021419-nypnib0h	241	16	of	of	IN
cord-021419-nypnib0h	241	17	macrolide	macrolide	JJ
cord-021419-nypnib0h	241	18	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	241	19	with	with	IN
cord-021419-nypnib0h	241	20	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	241	21	or	or	CC
cord-021419-nypnib0h	241	22	polycyclic	polycyclic	JJ
cord-021419-nypnib0h	241	23	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	241	24	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	241	25	and	and	CC
cord-021419-nypnib0h	241	26	synthesized	synthesize	VBN
cord-021419-nypnib0h	241	27	series	series	NN
cord-021419-nypnib0h	241	28	of	of	IN
cord-021419-nypnib0h	241	29	new	new	JJ
cord-021419-nypnib0h	241	30	chimeric	chimeric	JJ
cord-021419-nypnib0h	241	31	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	241	32	.	.	.
cord-021419-nypnib0h	242	1	Conjugates	Conjugates	NNP
cord-021419-nypnib0h	242	2	based	base	VBN
cord-021419-nypnib0h	242	3	on	on	IN
cord-021419-nypnib0h	242	4	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	242	5	(	(	-LRB-
cord-021419-nypnib0h	242	6	29	29	CD
cord-021419-nypnib0h	242	7	)	)	-RRB-
cord-021419-nypnib0h	242	8	,	,	,
cord-021419-nypnib0h	242	9	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	242	10	(	(	-LRB-
cord-021419-nypnib0h	242	11	30	30	CD
cord-021419-nypnib0h	242	12	)	)	-RRB-
cord-021419-nypnib0h	242	13	and	and	CC
cord-021419-nypnib0h	242	14	various	various	JJ
cord-021419-nypnib0h	242	15	substituted	substitute	VBN
cord-021419-nypnib0h	242	16	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	242	17	were	be	VBD
cord-021419-nypnib0h	242	18	synthesized	synthesize	VBN
cord-021419-nypnib0h	242	19	by	by	IN
cord-021419-nypnib0h	242	20	the	the	DT
cord-021419-nypnib0h	242	21	targeted	target	VBN
cord-021419-nypnib0h	242	22	modification	modification	NN
cord-021419-nypnib0h	242	23	of	of	IN
cord-021419-nypnib0h	242	24	macrolides	macrolide	NNS
cord-021419-nypnib0h	242	25	at	at	IN
cord-021419-nypnib0h	242	26	the	the	DT
cord-021419-nypnib0h	242	27	C(9	C(9	NNP
cord-021419-nypnib0h	242	28	)	)	-RRB-
cord-021419-nypnib0h	242	29	,	,	,
cord-021419-nypnib0h	242	30	C(2	C(2	NNP
cord-021419-nypnib0h	242	31	H	H	NNP
cord-021419-nypnib0h	242	32	)	)	-RRB-
cord-021419-nypnib0h	242	33	and	and	CC
cord-021419-nypnib0h	242	34	C(4	C(4	NNP
cord-021419-nypnib0h	242	35	HH	HH	NNP
cord-021419-nypnib0h	242	36	)	)	-RRB-
cord-021419-nypnib0h	242	37	atoms	atom	NNS
cord-021419-nypnib0h	242	38	and	and	CC
cord-021419-nypnib0h	242	39	the	the	DT
cord-021419-nypnib0h	242	40	C(11	C(11	NNP
cord-021419-nypnib0h	242	41	)	)	-RRB-
cord-021419-nypnib0h	242	42	±	±	NNP
cord-021419-nypnib0h	242	43	C(12	C(12	NNP
cord-021419-nypnib0h	242	44	)	)	-RRB-
cord-021419-nypnib0h	242	45	bond	bond	NN
cord-021419-nypnib0h	242	46	(	(	-LRB-
cord-021419-nypnib0h	242	47	see	see	VB
cord-021419-nypnib0h	242	48	Fig	Fig	NNP
cord-021419-nypnib0h	242	49	.	.	.
cord-021419-nypnib0h	243	1	4	4	LS
cord-021419-nypnib0h	243	2	a	a	DT
cord-021419-nypnib0h	243	3	±	±	NNP
cord-021419-nypnib0h	243	4	d	d	NN
cord-021419-nypnib0h	243	5	)	)	-RRB-
cord-021419-nypnib0h	243	6	.	.	.
cord-021419-nypnib0h	244	1	According	accord	VBG
cord-021419-nypnib0h	244	2	to	to	IN
cord-021419-nypnib0h	244	3	the	the	DT
cord-021419-nypnib0h	244	4	literature	literature	NN
cord-021419-nypnib0h	244	5	data	datum	NNS
cord-021419-nypnib0h	244	6	,	,	,
cord-021419-nypnib0h	244	7	the	the	DT
cord-021419-nypnib0h	244	8	introduction	introduction	NN
cord-021419-nypnib0h	244	9	of	of	IN
cord-021419-nypnib0h	244	10	arylalkyl	arylalkyl	NNP
cord-021419-nypnib0h	244	11	groups	group	NNS
cord-021419-nypnib0h	244	12	at	at	IN
cord-021419-nypnib0h	244	13	the	the	DT
cord-021419-nypnib0h	244	14	4	4	CD
cord-021419-nypnib0h	244	15	HH	HH	NNP
cord-021419-nypnib0h	244	16	position	position	NN
cord-021419-nypnib0h	244	17	of	of	IN
cord-021419-nypnib0h	244	18	the	the	DT
cord-021419-nypnib0h	244	19	cladinose	cladinose	JJ
cord-021419-nypnib0h	244	20	moiety	moiety	NN
cord-021419-nypnib0h	244	21	may	may	MD
cord-021419-nypnib0h	244	22	help	help	VB
cord-021419-nypnib0h	244	23	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	244	24	overcome	overcome	VB
cord-021419-nypnib0h	244	25	resistance	resistance	NN
cord-021419-nypnib0h	244	26	caused	cause	VBN
cord-021419-nypnib0h	244	27	by	by	IN
cord-021419-nypnib0h	244	28	methylation	methylation	NN
cord-021419-nypnib0h	244	29	of	of	IN
cord-021419-nypnib0h	244	30	the	the	DT
cord-021419-nypnib0h	244	31	macrolide	macrolide	NN
cord-021419-nypnib0h	244	32	-	-	HYPH
cord-021419-nypnib0h	244	33	binding	bind	VBG
cord-021419-nypnib0h	244	34	site	site	NN
cord-021419-nypnib0h	244	35	of	of	IN
cord-021419-nypnib0h	244	36	23S	23S	NNP
cord-021419-nypnib0h	244	37	rRNA	rRNA	NNP
cord-021419-nypnib0h	244	38	of	of	IN
cord-021419-nypnib0h	244	39	the	the	DT
cord-021419-nypnib0h	244	40	large	large	JJ
cord-021419-nypnib0h	244	41	ribosomal	ribosomal	JJ
cord-021419-nypnib0h	244	42	subunit	subunit	NN
cord-021419-nypnib0h	244	43	.	.	.
cord-021419-nypnib0h	245	1	37	37	CD
cord-021419-nypnib0h	246	1	A	a	DT
cord-021419-nypnib0h	246	2	method	method	NN
cord-021419-nypnib0h	246	3	was	be	VBD
cord-021419-nypnib0h	246	4	developed	develop	VBN
cord-021419-nypnib0h	246	5	for	for	IN
cord-021419-nypnib0h	246	6	the	the	DT
cord-021419-nypnib0h	246	7	introduction	introduction	NN
cord-021419-nypnib0h	246	8	of	of	IN
cord-021419-nypnib0h	246	9	aminobenzoxaboroles	aminobenzoxaborole	NNS
cord-021419-nypnib0h	246	10	at	at	IN
cord-021419-nypnib0h	246	11	the	the	DT
cord-021419-nypnib0h	246	12	C(4	C(4	NNP
cord-021419-nypnib0h	246	13	HH	HH	NNP
cord-021419-nypnib0h	246	14	)	)	-RRB-
cord-021419-nypnib0h	246	15	atom	atom	NN
cord-021419-nypnib0h	246	16	of	of	IN
cord-021419-nypnib0h	246	17	the	the	DT
cord-021419-nypnib0h	246	18	cladinose	cladinose	JJ
cord-021419-nypnib0h	246	19	moiety	moiety	NN
cord-021419-nypnib0h	246	20	of	of	IN
cord-021419-nypnib0h	246	21	the	the	DT
cord-021419-nypnib0h	246	22	antibiotic	antibiotic	NN
cord-021419-nypnib0h	246	23	through	through	IN
cord-021419-nypnib0h	246	24	the	the	DT
cord-021419-nypnib0h	246	25	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	246	26	group	group	NN
cord-021419-nypnib0h	246	27	.	.	.
cord-021419-nypnib0h	247	1	38	38	CD
cord-021419-nypnib0h	247	2	Hybrid	hybrid	NN
cord-021419-nypnib0h	247	3	structures	structure	NNS
cord-021419-nypnib0h	247	4	containing	contain	VBG
cord-021419-nypnib0h	247	5	hydroxamic	hydroxamic	JJ
cord-021419-nypnib0h	247	6	acid	acid	NN
cord-021419-nypnib0h	247	7	-	-	HYPH
cord-021419-nypnib0h	247	8	derived	derive	VBN
cord-021419-nypnib0h	247	9	benzoxaborole	benzoxaborole	NN
cord-021419-nypnib0h	247	10	at	at	IN
cord-021419-nypnib0h	247	11	the	the	DT
cord-021419-nypnib0h	247	12	C(9	C(9	NNP
cord-021419-nypnib0h	247	13	)	)	-RRB-
cord-021419-nypnib0h	248	1	keto	keto	NNP
cord-021419-nypnib0h	248	2	group	group	NNP
cord-021419-nypnib0h	248	3	of	of	IN
cord-021419-nypnib0h	248	4	the	the	DT
cord-021419-nypnib0h	248	5	aglycone	aglycone	NNP
cord-021419-nypnib0h	248	6	were	be	VBD
cord-021419-nypnib0h	248	7	prepared	prepare	VBN
cord-021419-nypnib0h	248	8	,	,	,
cord-021419-nypnib0h	248	9	because	because	IN
cord-021419-nypnib0h	248	10	modification	modification	NN
cord-021419-nypnib0h	248	11	of	of	IN
cord-021419-nypnib0h	248	12	this	this	DT
cord-021419-nypnib0h	248	13	group	group	NN
cord-021419-nypnib0h	248	14	does	do	VBZ
cord-021419-nypnib0h	248	15	not	not	RB
cord-021419-nypnib0h	248	16	lead	lead	VB
cord-021419-nypnib0h	248	17	to	to	IN
cord-021419-nypnib0h	248	18	the	the	DT
cord-021419-nypnib0h	248	19	loss	loss	NN
cord-021419-nypnib0h	248	20	of	of	IN
cord-021419-nypnib0h	248	21	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	248	22	activity	activity	NN
cord-021419-nypnib0h	248	23	.	.	.
cord-021419-nypnib0h	249	1	Scheme	scheme	NN
cord-021419-nypnib0h	249	2	10	10	CD
cord-021419-nypnib0h	249	3	shows	show	VBZ
cord-021419-nypnib0h	249	4	the	the	DT
cord-021419-nypnib0h	249	5	synthesis	synthesis	NN
cord-021419-nypnib0h	249	6	of	of	IN
cord-021419-nypnib0h	249	7	conjugates	conjugate	NNS
cord-021419-nypnib0h	249	8	based	base	VBN
cord-021419-nypnib0h	249	9	on	on	IN
cord-021419-nypnib0h	249	10	clarithromycin	clarithromycin	NNPS
cord-021419-nypnib0h	249	11	29	29	CD
cord-021419-nypnib0h	249	12	via	via	IN
cord-021419-nypnib0h	249	13	the	the	DT
cord-021419-nypnib0h	249	14	introduction	introduction	NN
cord-021419-nypnib0h	249	15	of	of	IN
cord-021419-nypnib0h	249	16	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	249	17	groups	group	NNS
cord-021419-nypnib0h	249	18	(	(	-LRB-
cord-021419-nypnib0h	249	19	A	a	NN
cord-021419-nypnib0h	249	20	and	and	CC
cord-021419-nypnib0h	249	21	B	B	NNP
cord-021419-nypnib0h	249	22	)	)	-RRB-
cord-021419-nypnib0h	249	23	into	into	IN
cord-021419-nypnib0h	249	24	the	the	DT
cord-021419-nypnib0h	249	25	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	249	26	molecule	molecule	NN
cord-021419-nypnib0h	249	27	at	at	IN
cord-021419-nypnib0h	249	28	the	the	DT
cord-021419-nypnib0h	249	29	C(9	C(9	NNP
cord-021419-nypnib0h	249	30	)	)	-RRB-
cord-021419-nypnib0h	249	31	atom	atom	NN
cord-021419-nypnib0h	249	32	of	of	IN
cord-021419-nypnib0h	249	33	the	the	DT
cord-021419-nypnib0h	249	34	aglycone	aglycone	NN
cord-021419-nypnib0h	249	35	or	or	CC
cord-021419-nypnib0h	249	36	at	at	IN
cord-021419-nypnib0h	249	37	C(4	C(4	NNP
cord-021419-nypnib0h	249	38	HH	HH	NNP
cord-021419-nypnib0h	249	39	)	)	-RRB-
cord-021419-nypnib0h	250	1	7O	7o	RB
cord-021419-nypnib0h	250	2	-	-	HYPH
cord-021419-nypnib0h	250	3	cladinose	cladinose	VBN
cord-021419-nypnib0h	250	4	with	with	IN
cord-021419-nypnib0h	250	5	acetyl	acetyl	NN
cord-021419-nypnib0h	250	6	protection	protection	NN
cord-021419-nypnib0h	250	7	of	of	IN
cord-021419-nypnib0h	250	8	the	the	DT
cord-021419-nypnib0h	250	9	C(2	C(2	NNP
cord-021419-nypnib0h	250	10	H	h	NN
cord-021419-nypnib0h	250	11	)	)	-RRB-
cord-021419-nypnib0h	250	12	7OH	7oh	CD
cord-021419-nypnib0h	250	13	group	group	NN
cord-021419-nypnib0h	250	14	of	of	IN
cord-021419-nypnib0h	250	15	desosamine	desosamine	NNP
cord-021419-nypnib0h	250	16	.	.	.
cord-021419-nypnib0h	251	1	38	38	CD
cord-021419-nypnib0h	252	1	The	the	DT
cord-021419-nypnib0h	252	2	former	former	JJ
cord-021419-nypnib0h	252	3	approach	approach	NN
cord-021419-nypnib0h	252	4	is	be	VBZ
cord-021419-nypnib0h	252	5	based	base	VBN
cord-021419-nypnib0h	252	6	on	on	IN
cord-021419-nypnib0h	252	7	the	the	DT
cord-021419-nypnib0h	252	8	treatment	treatment	NN
cord-021419-nypnib0h	252	9	of	of	IN
cord-021419-nypnib0h	252	10	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	252	11	(	(	-LRB-
cord-021419-nypnib0h	252	12	29	29	CD
cord-021419-nypnib0h	252	13	)	)	-RRB-
cord-021419-nypnib0h	252	14	with	with	IN
cord-021419-nypnib0h	252	15	aminoacetic	aminoacetic	JJ
cord-021419-nypnib0h	252	16	acid	acid	NN
cord-021419-nypnib0h	252	17	giving	give	VBG
cord-021419-nypnib0h	252	18	intermediate	intermediate	JJ
cord-021419-nypnib0h	252	19	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	252	20	9-syn(anti)-(O	9-syn(anti)-(O	NNP
cord-021419-nypnib0h	252	21	-	-	HYPH
cord-021419-nypnib0h	252	22	carboxymethyl)oxime	carboxymethyl)oxime	NNP
cord-021419-nypnib0h	252	23	(	(	-LRB-
cord-021419-nypnib0h	252	24	31a	31a	NNS
cord-021419-nypnib0h	252	25	)	)	-RRB-
cord-021419-nypnib0h	252	26	.	.	.
cord-021419-nypnib0h	253	1	The	the	DT
cord-021419-nypnib0h	253	2	reaction	reaction	NN
cord-021419-nypnib0h	253	3	of	of	IN
cord-021419-nypnib0h	253	4	31a	31a	NNS
cord-021419-nypnib0h	253	5	with	with	IN
cord-021419-nypnib0h	253	6	aminobenzoxaboroles	aminobenzoxaboroles	NNP
cord-021419-nypnib0h	253	7	HA	HA	NNP
cord-021419-nypnib0h	253	8	Figure	figure	NN
cord-021419-nypnib0h	253	9	4	4	CD
cord-021419-nypnib0h	253	10	.	.	.
cord-021419-nypnib0h	254	1	Structures	structure	NNS
cord-021419-nypnib0h	254	2	of	of	IN
cord-021419-nypnib0h	254	3	the	the	DT
cord-021419-nypnib0h	254	4	macrolide	macrolide	NN
cord-021419-nypnib0h	254	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	254	6	clarithromycin	clarithromycin	NNP
cord-021419-nypnib0h	254	7	(	(	-LRB-
cord-021419-nypnib0h	254	8	29	29	CD
cord-021419-nypnib0h	254	9	)	)	-RRB-
cord-021419-nypnib0h	254	10	and	and	CC
cord-021419-nypnib0h	254	11	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	254	12	(	(	-LRB-
cord-021419-nypnib0h	254	13	30	30	CD
cord-021419-nypnib0h	254	14	)	)	-RRB-
cord-021419-nypnib0h	254	15	.	.	.
cord-021419-nypnib0h	255	1	Arrows	arrow	NNS
cord-021419-nypnib0h	255	2	indicate	indicate	VBP
cord-021419-nypnib0h	255	3	the	the	DT
cord-021419-nypnib0h	255	4	directions	direction	NNS
cord-021419-nypnib0h	255	5	of	of	IN
cord-021419-nypnib0h	255	6	modification	modification	NN
cord-021419-nypnib0h	255	7	:	:	:
cord-021419-nypnib0h	255	8	at	at	IN
cord-021419-nypnib0h	255	9	the	the	DT
cord-021419-nypnib0h	255	10	9	9	CD
cord-021419-nypnib0h	255	11	position	position	NN
cord-021419-nypnib0h	255	12	of	of	IN
cord-021419-nypnib0h	255	13	the	the	DT
cord-021419-nypnib0h	255	14	aglycone	aglycone	NN
cord-021419-nypnib0h	255	15	(	(	-LRB-
cord-021419-nypnib0h	255	16	a	a	NN
cord-021419-nypnib0h	255	17	)	)	-RRB-
cord-021419-nypnib0h	255	18	,	,	,
cord-021419-nypnib0h	255	19	at	at	IN
cord-021419-nypnib0h	255	20	the	the	DT
cord-021419-nypnib0h	255	21	C(2	C(2	NNP
cord-021419-nypnib0h	255	22	H	h	NN
cord-021419-nypnib0h	255	23	)	)	-RRB-
cord-021419-nypnib0h	255	24	7OH	7oh	CD
cord-021419-nypnib0h	255	25	group	group	NN
cord-021419-nypnib0h	255	26	of	of	IN
cord-021419-nypnib0h	255	27	desosamine	desosamine	NNP
cord-021419-nypnib0h	255	28	(	(	-LRB-
cord-021419-nypnib0h	255	29	b	b	NN
cord-021419-nypnib0h	255	30	)	)	-RRB-
cord-021419-nypnib0h	255	31	,	,	,
cord-021419-nypnib0h	255	32	at	at	IN
cord-021419-nypnib0h	255	33	the	the	DT
cord-021419-nypnib0h	255	34	C(4	C(4	NNP
cord-021419-nypnib0h	255	35	HH	HH	NNP
cord-021419-nypnib0h	255	36	)	)	-RRB-
cord-021419-nypnib0h	255	37	atom	atom	NN
cord-021419-nypnib0h	255	38	of	of	IN
cord-021419-nypnib0h	255	39	cladinose	cladinose	NNP
cord-021419-nypnib0h	255	40	(	(	-LRB-
cord-021419-nypnib0h	255	41	c	c	NNP
cord-021419-nypnib0h	255	42	)	)	-RRB-
cord-021419-nypnib0h	255	43	,	,	,
cord-021419-nypnib0h	255	44	the	the	DT
cord-021419-nypnib0h	255	45	formation	formation	NN
cord-021419-nypnib0h	255	46	of	of	IN
cord-021419-nypnib0h	255	47	C(11),C(12)-cyclic	C(11),C(12)-cyclic	NNP
cord-021419-nypnib0h	255	48	carbonate	carbonate	NN
cord-021419-nypnib0h	255	49	and	and	CC
cord-021419-nypnib0h	255	50	modification	modification	NN
cord-021419-nypnib0h	255	51	of	of	IN
cord-021419-nypnib0h	255	52	the	the	DT
cord-021419-nypnib0h	255	53	C(11	C(11	NNP
cord-021419-nypnib0h	255	54	)	)	-RRB-
cord-021419-nypnib0h	255	55	atom	atom	NN
cord-021419-nypnib0h	255	56	(	(	-LRB-
cord-021419-nypnib0h	255	57	d	d	NN
cord-021419-nypnib0h	255	58	)	)	-RRB-
cord-021419-nypnib0h	255	59	.	.	.
cord-021419-nypnib0h	256	1	or	or	CC
cord-021419-nypnib0h	256	2	HB	HB	NNP
cord-021419-nypnib0h	256	3	gives	give	VBZ
cord-021419-nypnib0h	256	4	the	the	DT
cord-021419-nypnib0h	256	5	corresponding	correspond	VBG
cord-021419-nypnib0h	256	6	amides	amide	NNS
cord-021419-nypnib0h	256	7	of	of	IN
cord-021419-nypnib0h	256	8	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	256	9	(	(	-LRB-
cord-021419-nypnib0h	256	10	E	E	NNP
cord-021419-nypnib0h	256	11	/	/	SYM
cord-021419-nypnib0h	256	12	Z)-9-carboxymethoxime	Z)-9-carboxymethoxime	NNP
cord-021419-nypnib0h	256	13	31b	31b	NNS
cord-021419-nypnib0h	256	14	,	,	,
cord-021419-nypnib0h	256	15	c	c	NNP
cord-021419-nypnib0h	256	16	(	(	-LRB-
cord-021419-nypnib0h	256	17	see	see	VB
cord-021419-nypnib0h	256	18	Scheme	Scheme	NNP
cord-021419-nypnib0h	256	19	10	10	CD
cord-021419-nypnib0h	256	20	)	)	-RRB-
cord-021419-nypnib0h	256	21	.	.	.
cord-021419-nypnib0h	257	1	Another	another	DT
cord-021419-nypnib0h	257	2	approach	approach	NN
cord-021419-nypnib0h	257	3	was	be	VBD
cord-021419-nypnib0h	257	4	accomplished	accomplish	VBN
cord-021419-nypnib0h	257	5	by	by	IN
cord-021419-nypnib0h	257	6	a	a	DT
cord-021419-nypnib0h	257	7	modified	modify	VBN
cord-021419-nypnib0h	257	8	procedure	procedure	NN
cord-021419-nypnib0h	257	9	39	39	CD
cord-021419-nypnib0h	257	10	involving	involve	VBG
cord-021419-nypnib0h	257	11	the	the	DT
cord-021419-nypnib0h	257	12	following	follow	VBG
cord-021419-nypnib0h	257	13	four	four	CD
cord-021419-nypnib0h	257	14	steps	step	NNS
cord-021419-nypnib0h	257	15	:	:	:
cord-021419-nypnib0h	257	16	the	the	DT
cord-021419-nypnib0h	257	17	protection	protection	NN
cord-021419-nypnib0h	257	18	of	of	IN
cord-021419-nypnib0h	257	19	the	the	DT
cord-021419-nypnib0h	257	20	C(2	C(2	NNP
cord-021419-nypnib0h	257	21	H	h	NN
cord-021419-nypnib0h	257	22	)	)	-RRB-
cord-021419-nypnib0h	257	23	7OH	7oh	CD
cord-021419-nypnib0h	257	24	group	group	NN
cord-021419-nypnib0h	257	25	of	of	IN
cord-021419-nypnib0h	257	26	desosamine	desosamine	NNP
cord-021419-nypnib0h	257	27	by	by	IN
cord-021419-nypnib0h	257	28	the	the	DT
cord-021419-nypnib0h	257	29	acetyl	acetyl	NNP
cord-021419-nypnib0h	257	30	group	group	NN
cord-021419-nypnib0h	257	31	giving	give	VBG
cord-021419-nypnib0h	257	32	2	2	CD
cord-021419-nypnib0h	257	33	H	h	NN
cord-021419-nypnib0h	257	34	-OAc	-OAc	NNS
cord-021419-nypnib0h	257	35	-	-	:
cord-021419-nypnib0h	257	36	clarithromycin	clarithromycin	NNPS
cord-021419-nypnib0h	257	37	(	(	-LRB-
cord-021419-nypnib0h	257	38	32	32	CD
cord-021419-nypnib0h	257	39	)	)	-RRB-
cord-021419-nypnib0h	257	40	,	,	,
cord-021419-nypnib0h	257	41	the	the	DT
cord-021419-nypnib0h	257	42	transformation	transformation	NN
cord-021419-nypnib0h	257	43	of	of	IN
cord-021419-nypnib0h	257	44	the	the	DT
cord-021419-nypnib0h	257	45	latter	latter	JJ
cord-021419-nypnib0h	257	46	into	into	IN
cord-021419-nypnib0h	257	47	activated	activate	VBN
cord-021419-nypnib0h	257	48	2	2	CD
cord-021419-nypnib0h	257	49	H	h	NN
cord-021419-nypnib0h	257	50	-OAc	-OAc	NNS
cord-021419-nypnib0h	257	51	-	-	:
cord-021419-nypnib0h	257	52	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	257	53	4	4	CD
cord-021419-nypnib0h	257	54	HH	HH	NNP
cord-021419-nypnib0h	257	55	-O-1H	-O-1H	:
cord-021419-nypnib0h	257	56	-	-	:
cord-021419-nypnib0h	257	57	imidazole-1-carboxylate	imidazole-1-carboxylate	JJ
cord-021419-nypnib0h	257	58	(	(	-LRB-
cord-021419-nypnib0h	257	59	33	33	CD
cord-021419-nypnib0h	257	60	)	)	-RRB-
cord-021419-nypnib0h	257	61	by	by	IN
cord-021419-nypnib0h	257	62	the	the	DT
cord-021419-nypnib0h	257	63	treatment	treatment	NN
cord-021419-nypnib0h	257	64	with	with	IN
cord-021419-nypnib0h	257	65	carbonyldiimidazole	carbonyldiimidazole	NNP
cord-021419-nypnib0h	257	66	(	(	-LRB-
cord-021419-nypnib0h	257	67	CDI	CDI	NNP
cord-021419-nypnib0h	257	68	)	)	-RRB-
cord-021419-nypnib0h	257	69	,	,	,
cord-021419-nypnib0h	257	70	the	the	DT
cord-021419-nypnib0h	257	71	amidation	amidation	NN
cord-021419-nypnib0h	257	72	of	of	IN
cord-021419-nypnib0h	257	73	33	33	CD
cord-021419-nypnib0h	257	74	with	with	IN
cord-021419-nypnib0h	257	75	amines	amine	NNS
cord-021419-nypnib0h	257	76	HA	HA	NNP
cord-021419-nypnib0h	257	77	or	or	CC
cord-021419-nypnib0h	257	78	HB	HB	NNP
cord-021419-nypnib0h	257	79	in	in	IN
cord-021419-nypnib0h	257	80	the	the	DT
cord-021419-nypnib0h	257	81	presence	presence	NN
cord-021419-nypnib0h	257	82	of	of	IN
cord-021419-nypnib0h	257	83	the	the	DT
cord-021419-nypnib0h	257	84	peptide	peptide	NN
cord-021419-nypnib0h	257	85	coupling	coupling	NN
cord-021419-nypnib0h	257	86	reagent	reagent	NN
cord-021419-nypnib0h	257	87	1,8-diazobicyclo	1,8-diazobicyclo	CD
cord-021419-nypnib0h	257	88	[	[	-LRB-
cord-021419-nypnib0h	257	89	5.4	5.4	CD
cord-021419-nypnib0h	257	90	.0]undec-7-ene	.0]undec-7-ene	.
cord-021419-nypnib0h	258	1	(	(	-LRB-
cord-021419-nypnib0h	258	2	DBU	DBU	NNP
cord-021419-nypnib0h	258	3	)	)	-RRB-
cord-021419-nypnib0h	259	1	giving	give	VBG
cord-021419-nypnib0h	259	2	2	2	CD
cord-021419-nypnib0h	259	3	H	h	NN
cord-021419-nypnib0h	259	4	-OAc	-OAc	NNS
cord-021419-nypnib0h	259	5	-	-	HYPH
cord-021419-nypnib0h	259	6	substituted	substitute	VBN
cord-021419-nypnib0h	259	7	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	259	8	derivatives	derivative	NNS
cord-021419-nypnib0h	259	9	of	of	IN
cord-021419-nypnib0h	259	10	clarithromycin	clarithromycin	NNP
cord-021419-nypnib0h	259	11	34a	34a	NNP
cord-021419-nypnib0h	259	12	,	,	,
cord-021419-nypnib0h	259	13	b	b	NN
cord-021419-nypnib0h	259	14	,	,	,
cord-021419-nypnib0h	259	15	and	and	CC
cord-021419-nypnib0h	259	16	the	the	DT
cord-021419-nypnib0h	259	17	deacetylation	deacetylation	NN
cord-021419-nypnib0h	259	18	of	of	IN
cord-021419-nypnib0h	259	19	34a	34a	NNS
cord-021419-nypnib0h	259	20	,	,	,
cord-021419-nypnib0h	259	21	b	b	VBN
cord-021419-nypnib0h	259	22	by	by	IN
cord-021419-nypnib0h	259	23	heating	heating	NN
cord-021419-nypnib0h	259	24	in	in	IN
cord-021419-nypnib0h	259	25	methanol	methanol	NN
cord-021419-nypnib0h	259	26	to	to	TO
cord-021419-nypnib0h	259	27	form	form	VB
cord-021419-nypnib0h	259	28	target	target	VB
cord-021419-nypnib0h	259	29	unprotected	unprotected	JJ
cord-021419-nypnib0h	259	30	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	259	31	derivatives	derivative	NNS
cord-021419-nypnib0h	259	32	of	of	IN
cord-021419-nypnib0h	259	33	clarithromycin	clarithromycin	NNS
cord-021419-nypnib0h	259	34	35a	35a	NNS
cord-021419-nypnib0h	259	35	,	,	,
cord-021419-nypnib0h	259	36	b	b	NN
cord-021419-nypnib0h	259	37	.	.	.
cord-021419-nypnib0h	260	1	Compounds	compound	NNS
cord-021419-nypnib0h	260	2	31b	31b	NNS
cord-021419-nypnib0h	260	3	,	,	,
cord-021419-nypnib0h	260	4	c	c	NN
cord-021419-nypnib0h	260	5	and	and	CC
cord-021419-nypnib0h	260	6	35a	35a	NNS
cord-021419-nypnib0h	260	7	,	,	.
cord-021419-nypnib0h	261	1	b	b	LS
cord-021419-nypnib0h	261	2	exhibit	exhibit	VB
cord-021419-nypnib0h	261	3	the	the	DT
cord-021419-nypnib0h	261	4	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	261	5	effect	effect	NN
cord-021419-nypnib0h	261	6	against	against	IN
cord-021419-nypnib0h	261	7	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	261	8	and	and	CC
cord-021419-nypnib0h	261	9	streptococci	streptococcus	NNS
cord-021419-nypnib0h	261	10	comparable	comparable	JJ
cord-021419-nypnib0h	261	11	with	with	IN
cord-021419-nypnib0h	261	12	the	the	DT
cord-021419-nypnib0h	261	13	activity	activity	NN
cord-021419-nypnib0h	261	14	of	of	IN
cord-021419-nypnib0h	261	15	starting	start	VBG
cord-021419-nypnib0h	261	16	compound	compound	NN
cord-021419-nypnib0h	261	17	29	29	CD
cord-021419-nypnib0h	261	18	.	.	.
cord-021419-nypnib0h	262	1	In	in	IN
cord-021419-nypnib0h	262	2	these	these	DT
cord-021419-nypnib0h	262	3	assays	assay	NNS
cord-021419-nypnib0h	262	4	,	,	,
cord-021419-nypnib0h	262	5	derivatives	derivative	NNS
cord-021419-nypnib0h	262	6	at	at	IN
cord-021419-nypnib0h	262	7	the	the	DT
cord-021419-nypnib0h	262	8	C(4	C(4	NNP
cord-021419-nypnib0h	262	9	HH	HH	NNP
cord-021419-nypnib0h	262	10	)	)	-RRB-
cord-021419-nypnib0h	263	1	-cladinose	-cladinose	.
cord-021419-nypnib0h	264	1	position	position	NN
cord-021419-nypnib0h	264	2	were	be	VBD
cord-021419-nypnib0h	264	3	found	find	VBN
cord-021419-nypnib0h	264	4	to	to	TO
cord-021419-nypnib0h	264	5	be	be	VB
cord-021419-nypnib0h	264	6	more	more	RBR
cord-021419-nypnib0h	264	7	effective	effective	JJ
cord-021419-nypnib0h	264	8	than	than	IN
cord-021419-nypnib0h	264	9	the	the	DT
cord-021419-nypnib0h	264	10	derivatives	derivative	NNS
cord-021419-nypnib0h	264	11	at	at	IN
cord-021419-nypnib0h	264	12	the	the	DT
cord-021419-nypnib0h	264	13	C(9	C(9	NNP
cord-021419-nypnib0h	264	14	)	)	-RRB-
cord-021419-nypnib0h	264	15	position	position	NN
cord-021419-nypnib0h	264	16	of	of	IN
cord-021419-nypnib0h	264	17	the	the	DT
cord-021419-nypnib0h	264	18	aglycone	aglycone	NN
cord-021419-nypnib0h	264	19	of	of	IN
cord-021419-nypnib0h	264	20	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	264	21	31b	31b	NNS
cord-021419-nypnib0h	264	22	and	and	CC
cord-021419-nypnib0h	264	23	31c	31c	NNS
cord-021419-nypnib0h	264	24	.	.	.
cord-021419-nypnib0h	265	1	Compound	compound	NN
cord-021419-nypnib0h	265	2	35b	35b	NNS
cord-021419-nypnib0h	265	3	is	be	VBZ
cord-021419-nypnib0h	265	4	the	the	DT
cord-021419-nypnib0h	265	5	most	most	RBS
cord-021419-nypnib0h	265	6	effective	effective	JJ
cord-021419-nypnib0h	265	7	against	against	IN
cord-021419-nypnib0h	265	8	the	the	DT
cord-021419-nypnib0h	265	9	strains	strain	NNS
cord-021419-nypnib0h	265	10	Staphylococcus	Staphylococcus	NNP
cord-021419-nypnib0h	265	11	epidermidis	epidermidi	NNS
cord-021419-nypnib0h	265	12	ATCC	ATCC	NNP
cord-021419-nypnib0h	265	13	12228	12228	CD
cord-021419-nypnib0h	265	14	and	and	CC
cord-021419-nypnib0h	265	15	Streptococcus	streptococcus	NN
cord-021419-nypnib0h	265	16	pneumoniae	pneumoniae	NN
cord-021419-nypnib0h	265	17	ATCC	ATCC	NNP
cord-021419-nypnib0h	265	18	49619	49619	CD
cord-021419-nypnib0h	265	19	.	.	.
cord-021419-nypnib0h	266	1	Clarithromycin	Clarithromycin	NNP
cord-021419-nypnib0h	266	2	analogues	analogue	NNS
cord-021419-nypnib0h	266	3	31c	31c	NNS
cord-021419-nypnib0h	266	4	and	and	CC
cord-021419-nypnib0h	266	5	35b	35b	NNS
cord-021419-nypnib0h	266	6	possess	possess	VBP
cord-021419-nypnib0h	266	7	an	an	DT
cord-021419-nypnib0h	266	8	opposite	opposite	JJ
cord-021419-nypnib0h	266	9	activity	activity	NN
cord-021419-nypnib0h	266	10	against	against	IN
cord-021419-nypnib0h	266	11	Gram	gram	NN
cord-021419-nypnib0h	266	12	-	-	HYPH
cord-021419-nypnib0h	266	13	negative	negative	JJ
cord-021419-nypnib0h	266	14	bacteria	bacteria	NNS
cord-021419-nypnib0h	266	15	,	,	,
cord-021419-nypnib0h	266	16	such	such	JJ
cord-021419-nypnib0h	266	17	as	as	IN
cord-021419-nypnib0h	266	18	sensitive	sensitive	JJ
cord-021419-nypnib0h	266	19	strains	strain	NNS
cord-021419-nypnib0h	266	20	of	of	IN
cord-021419-nypnib0h	266	21	E.	E.	NNP
cord-021419-nypnib0h	266	22	coli	coli	NNS
cord-021419-nypnib0h	266	23	and	and	CC
cord-021419-nypnib0h	266	24	resistant	resistant	JJ
cord-021419-nypnib0h	266	25	strains	strain	NNS
cord-021419-nypnib0h	266	26	of	of	IN
cord-021419-nypnib0h	266	27	E.	E.	NNP
cord-021419-nypnib0h	266	28	coli	coli	NNS
cord-021419-nypnib0h	266	29	(	(	-LRB-
cord-021419-nypnib0h	266	30	tolC	tolc	CD
cord-021419-nypnib0h	266	31	and	and	CC
cord-021419-nypnib0h	266	32	tolC	tolC	VBZ
cord-021419-nypnib0h	266	33	pUC	puc	PRP$
cord-021419-nypnib0h	266	34	erm42	erm42	CD
cord-021419-nypnib0h	266	35	)	)	-RRB-
cord-021419-nypnib0h	266	36	.	.	.
cord-021419-nypnib0h	267	1	Thus	thus	RB
cord-021419-nypnib0h	267	2	,	,	,
cord-021419-nypnib0h	267	3	compound	compound	NN
cord-021419-nypnib0h	267	4	31c	31c	NNS
cord-021419-nypnib0h	267	5	is	be	VBZ
cord-021419-nypnib0h	267	6	more	more	RBR
cord-021419-nypnib0h	267	7	active	active	JJ
cord-021419-nypnib0h	267	8	than	than	IN
cord-021419-nypnib0h	267	9	35b	35b	NNS
cord-021419-nypnib0h	267	10	.	.	.
cord-021419-nypnib0h	268	1	In	in	IN
cord-021419-nypnib0h	268	2	the	the	DT
cord-021419-nypnib0h	268	3	former	former	JJ
cord-021419-nypnib0h	268	4	case	case	NN
cord-021419-nypnib0h	268	5	,	,	,
cord-021419-nypnib0h	268	6	E.	E.	NNP
cord-021419-nypnib0h	268	7	coli	coli	VBZ
cord-021419-nypnib0h	268	8	tolC	tolc	CD
cord-021419-nypnib0h	268	9	and	and	CC
cord-021419-nypnib0h	268	10	tolC	tolC	VBZ
cord-021419-nypnib0h	268	11	pUC	puc	PRP$
cord-021419-nypnib0h	268	12	erm42	erm42	NNS
cord-021419-nypnib0h	268	13	are	be	VBP
cord-021419-nypnib0h	268	14	bacterial	bacterial	JJ
cord-021419-nypnib0h	268	15	strains	strain	NNS
cord-021419-nypnib0h	268	16	containing	contain	VBG
cord-021419-nypnib0h	268	17	the	the	DT
cord-021419-nypnib0h	268	18	outer	outer	JJ
cord-021419-nypnib0h	268	19	membrane	membrane	NN
cord-021419-nypnib0h	268	20	protein	protein	NN
cord-021419-nypnib0h	268	21	tolC	tolC	NNS
cord-021419-nypnib0h	268	22	,	,	,
cord-021419-nypnib0h	268	23	which	which	WDT
cord-021419-nypnib0h	268	24	is	be	VBZ
cord-021419-nypnib0h	268	25	responsible	responsible	JJ
cord-021419-nypnib0h	268	26	for	for	IN
cord-021419-nypnib0h	268	27	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	268	28	efflux	efflux	NN
cord-021419-nypnib0h	268	29	from	from	IN
cord-021419-nypnib0h	268	30	the	the	DT
cord-021419-nypnib0h	268	31	cell	cell	NN
cord-021419-nypnib0h	268	32	.	.	.
cord-021419-nypnib0h	269	1	In	in	IN
cord-021419-nypnib0h	269	2	the	the	DT
cord-021419-nypnib0h	269	3	latter	latter	JJ
cord-021419-nypnib0h	269	4	cases	case	NNS
cord-021419-nypnib0h	269	5	,	,	,
cord-021419-nypnib0h	269	6	the	the	DT
cord-021419-nypnib0h	269	7	strain	strain	NN
cord-021419-nypnib0h	269	8	contains	contain	VBZ
cord-021419-nypnib0h	269	9	,	,	,
cord-021419-nypnib0h	269	10	apart	apart	RB
cord-021419-nypnib0h	269	11	from	from	IN
cord-021419-nypnib0h	269	12	tolC	tolc	CD
cord-021419-nypnib0h	269	13	,	,	,
cord-021419-nypnib0h	269	14	the	the	DT
cord-021419-nypnib0h	269	15	pUC	puc	DT
cord-021419-nypnib0h	269	16	plasmid	plasmid	NN
cord-021419-nypnib0h	269	17	cloning	cloning	NN
cord-021419-nypnib0h	269	18	vector	vector	NN
cord-021419-nypnib0h	269	19	and	and	CC
cord-021419-nypnib0h	269	20	methylase	methylase	NN
cord-021419-nypnib0h	269	21	erm42	erm42	NNS
cord-021419-nypnib0h	269	22	.	.	.
cord-021419-nypnib0h	270	1	38	38	CD
cord-021419-nypnib0h	270	2	 	 	_SP
cord-021419-nypnib0h	270	3	Attempts	Attempts	NNP
cord-021419-nypnib0h	270	4	were	be	VBD
cord-021419-nypnib0h	270	5	made	make	VBN
cord-021419-nypnib0h	270	6	to	to	TO
cord-021419-nypnib0h	270	7	extend	extend	VB
cord-021419-nypnib0h	270	8	the	the	DT
cord-021419-nypnib0h	270	9	method	method	NN
cord-021419-nypnib0h	270	10	developed	develop	VBN
cord-021419-nypnib0h	270	11	for	for	IN
cord-021419-nypnib0h	270	12	the	the	DT
cord-021419-nypnib0h	270	13	synthesis	synthesis	NN
cord-021419-nypnib0h	270	14	of	of	IN
cord-021419-nypnib0h	270	15	C(4	C(4	NNP
cord-021419-nypnib0h	270	16	HH	HH	NNP
cord-021419-nypnib0h	270	17	)	)	-RRB-
cord-021419-nypnib0h	271	1	-substituted	-substituted	NNP
cord-021419-nypnib0h	271	2	clarithromycin	clarithromycin	NNP
cord-021419-nypnib0h	271	3	±	±	NNP
cord-021419-nypnib0h	271	4	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	271	5	conjugates	conjugate	VBZ
cord-021419-nypnib0h	271	6	to	to	IN
cord-021419-nypnib0h	271	7	the	the	DT
cord-021419-nypnib0h	271	8	synthesis	synthesis	NN
cord-021419-nypnib0h	271	9	of	of	IN
cord-021419-nypnib0h	271	10	related	related	JJ
cord-021419-nypnib0h	271	11	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	271	12	conjugates	conjugate	NNS
cord-021419-nypnib0h	271	13	(	(	-LRB-
cord-021419-nypnib0h	271	14	Scheme	scheme	NN
cord-021419-nypnib0h	271	15	11	11	CD
cord-021419-nypnib0h	271	16	)	)	-RRB-
cord-021419-nypnib0h	271	17	.	.	.
cord-021419-nypnib0h	272	1	39	39	CD
cord-021419-nypnib0h	273	1	It	-PRON-	PRP
cord-021419-nypnib0h	273	2	appeared	appear	VBD
cord-021419-nypnib0h	273	3	that	that	IN
cord-021419-nypnib0h	273	4	the	the	DT
cord-021419-nypnib0h	273	5	success	success	NN
cord-021419-nypnib0h	273	6	of	of	IN
cord-021419-nypnib0h	273	7	introducing	introduce	VBG
cord-021419-nypnib0h	273	8	the	the	DT
cord-021419-nypnib0h	273	9	aminobenzoxaborole	aminobenzoxaborole	NNP
cord-021419-nypnib0h	273	10	moiety	moiety	VBZ
cord-021419-nypnib0h	273	11	into	into	IN
cord-021419-nypnib0h	273	12	a	a	DT
cord-021419-nypnib0h	273	13	macrolide	macrolide	JJ
cord-021419-nypnib0h	273	14	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	273	15	depends	depend	VBZ
cord-021419-nypnib0h	273	16	on	on	IN
cord-021419-nypnib0h	273	17	the	the	DT
cord-021419-nypnib0h	273	18	structure	structure	NN
cord-021419-nypnib0h	273	19	of	of	IN
cord-021419-nypnib0h	273	20	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	273	21	29	29	CD
cord-021419-nypnib0h	273	22	and	and	CC
cord-021419-nypnib0h	273	23	30	30	CD
cord-021419-nypnib0h	273	24	,	,	,
cord-021419-nypnib0h	273	25	as	as	RB
cord-021419-nypnib0h	273	26	well	well	RB
cord-021419-nypnib0h	273	27	as	as	IN
cord-021419-nypnib0h	273	28	on	on	IN
cord-021419-nypnib0h	273	29	the	the	DT
cord-021419-nypnib0h	273	30	structure	structure	NN
cord-021419-nypnib0h	273	31	of	of	IN
cord-021419-nypnib0h	273	32	aminobenzoxaborole	aminobenzoxaborole	NNP
cord-021419-nypnib0h	273	33	.	.	.
cord-021419-nypnib0h	274	1	The	the	DT
cord-021419-nypnib0h	274	2	acetylation	acetylation	NN
cord-021419-nypnib0h	274	3	of	of	IN
cord-021419-nypnib0h	274	4	azithromycin	azithromycin	NN
cord-021419-nypnib0h	274	5	(	(	-LRB-
cord-021419-nypnib0h	274	6	30	30	CD
cord-021419-nypnib0h	274	7	)	)	-RRB-
cord-021419-nypnib0h	274	8	giving	give	VBG
cord-021419-nypnib0h	274	9	the	the	DT
cord-021419-nypnib0h	274	10	2	2	CD
cord-021419-nypnib0h	274	11	H	h	NN
cord-021419-nypnib0h	274	12	-OAc	-OAc	NNS
cord-021419-nypnib0h	274	13	derivative	derivative	JJ
cord-021419-nypnib0h	274	14	(	(	-LRB-
cord-021419-nypnib0h	274	15	36	36	CD
cord-021419-nypnib0h	274	16	)	)	-RRB-
cord-021419-nypnib0h	274	17	followed	follow	VBN
cord-021419-nypnib0h	274	18	by	by	IN
cord-021419-nypnib0h	274	19	the	the	DT
cord-021419-nypnib0h	274	20	treatment	treatment	NN
cord-021419-nypnib0h	274	21	of	of	IN
cord-021419-nypnib0h	274	22	the	the	DT
cord-021419-nypnib0h	274	23	latter	latter	JJ
cord-021419-nypnib0h	274	24	with	with	IN
cord-021419-nypnib0h	274	25	N	N	NNP
cord-021419-nypnib0h	274	26	,	,	,
cord-021419-nypnib0h	274	27	N	N	NNP
cord-021419-nypnib0h	274	28	H	H	NNP
cord-021419-nypnib0h	274	29	-carbonyldiimidazole	-carbonyldiimidazole	:
cord-021419-nypnib0h	274	30	in	in	IN
cord-021419-nypnib0h	274	31	the	the	DT
cord-021419-nypnib0h	274	32	presence	presence	NN
cord-021419-nypnib0h	274	33	of	of	IN
cord-021419-nypnib0h	274	34	Et	Et	NNP
cord-021419-nypnib0h	274	35	3	3	CD
cord-021419-nypnib0h	274	36	N	N	NNP
cord-021419-nypnib0h	274	37	produces	produce	VBZ
cord-021419-nypnib0h	274	38	the	the	DT
cord-021419-nypnib0h	274	39	desired	desire	VBN
cord-021419-nypnib0h	274	40	activated	activate	VBN
cord-021419-nypnib0h	274	41	imidazole	imidazole	JJ
cord-021419-nypnib0h	274	42	derivative	derivative	JJ
cord-021419-nypnib0h	274	43	Ð	ð	NN
cord-021419-nypnib0h	275	1	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	275	2	2	2	CD
cord-021419-nypnib0h	275	3	H	h	NN
cord-021419-nypnib0h	275	4	-OAc-4	-OAc-4	HYPH
cord-021419-nypnib0h	275	5	HH	HH	NNP
cord-021419-nypnib0h	275	6	-O-1H	-O-1H	.
cord-021419-nypnib0h	276	1	-imidazole-1-carboxylate	-imidazole-1-carboxylate	:
cord-021419-nypnib0h	276	2	(	(	-LRB-
cord-021419-nypnib0h	276	3	37	37	CD
cord-021419-nypnib0h	276	4	)	)	-RRB-
cord-021419-nypnib0h	276	5	(	(	-LRB-
cord-021419-nypnib0h	276	6	see	see	VB
cord-021419-nypnib0h	276	7	Scheme	scheme	NN
cord-021419-nypnib0h	276	8	11	11	CD
cord-021419-nypnib0h	276	9	)	)	-RRB-
cord-021419-nypnib0h	276	10	.	.	.
cord-021419-nypnib0h	277	1	However	however	RB
cord-021419-nypnib0h	277	2	,	,	,
cord-021419-nypnib0h	277	3	unlike	unlike	IN
cord-021419-nypnib0h	277	4	the	the	DT
cord-021419-nypnib0h	277	5	synthesis	synthesis	NN
cord-021419-nypnib0h	277	6	of	of	IN
cord-021419-nypnib0h	277	7	clarithromycin	clarithromycin	NNP
cord-021419-nypnib0h	277	8	analogue	analogue	NN
cord-021419-nypnib0h	277	9	34a	34a	NNPS
cord-021419-nypnib0h	277	10	,	,	,
cord-021419-nypnib0h	277	11	the	the	DT
cord-021419-nypnib0h	277	12	amidation	amidation	NN
cord-021419-nypnib0h	277	13	of	of	IN
cord-021419-nypnib0h	277	14	compound	compound	NNP
cord-021419-nypnib0h	277	15	37	37	CD
cord-021419-nypnib0h	277	16	with	with	IN
cord-021419-nypnib0h	277	17	7-(hydroxy-1,3-dihydrobenzo[c	7-(hydroxy-1,3-dihydrobenzo[c	CD
cord-021419-nypnib0h	277	18	]	]	-RRB-
cord-021419-nypnib0h	277	19	[	[	-LRB-
cord-021419-nypnib0h	277	20	1	1	CD
cord-021419-nypnib0h	277	21	,	,	,
cord-021419-nypnib0h	277	22	2	2	CD
cord-021419-nypnib0h	277	23	]	]	-RRB-
cord-021419-nypnib0h	277	24	oxaborole)methylamine	oxaborole)methylamine	NN
cord-021419-nypnib0h	277	25	in	in	IN
cord-021419-nypnib0h	277	26	the	the	DT
cord-021419-nypnib0h	277	27	presence	presence	NN
cord-021419-nypnib0h	277	28	of	of	IN
cord-021419-nypnib0h	277	29	DBU	DBU	NNP
cord-021419-nypnib0h	277	30	does	do	VBZ
cord-021419-nypnib0h	277	31	not	not	RB
cord-021419-nypnib0h	277	32	give	give	VB
cord-021419-nypnib0h	277	33	the	the	DT
cord-021419-nypnib0h	277	34	desired	desire	VBN
cord-021419-nypnib0h	277	35	outcome	outcome	NN
cord-021419-nypnib0h	277	36	.	.	.
cord-021419-nypnib0h	278	1	The	the	DT
cord-021419-nypnib0h	278	2	introduction	introduction	NN
cord-021419-nypnib0h	278	3	of	of	IN
cord-021419-nypnib0h	278	4	the	the	DT
cord-021419-nypnib0h	278	5	latter	latter	JJ
cord-021419-nypnib0h	278	6	amine	amine	NN
cord-021419-nypnib0h	278	7	was	be	VBD
cord-021419-nypnib0h	278	8	accomplished	accomplish	VBN
cord-021419-nypnib0h	278	9	using	use	VBG
cord-021419-nypnib0h	278	10	the	the	DT
cord-021419-nypnib0h	278	11	trisubstituted	trisubstituted	NNP
cord-021419-nypnib0h	278	12	derivative	derivative	JJ
cord-021419-nypnib0h	278	13	,	,	,
cord-021419-nypnib0h	278	14	the	the	DT
cord-021419-nypnib0h	278	15	11,12-cyclic	11,12-cyclic	NNP
cord-021419-nypnib0h	278	16	carbonate	carbonate	NN
cord-021419-nypnib0h	278	17	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	278	18	2	2	CD
cord-021419-nypnib0h	278	19	H	h	NN
cord-021419-nypnib0h	278	20	-OAc-4	-OAc-4	HYPH
cord-021419-nypnib0h	278	21	HH	HH	NNP
cord-021419-nypnib0h	278	22	-O-1H	-O-1H	:
cord-021419-nypnib0h	278	23	-	-	:
cord-021419-nypnib0h	278	24	imidazole-1-carboxylate	imidazole-1-carboxylate	NNP
cord-021419-nypnib0h	278	25	38	38	CD
cord-021419-nypnib0h	278	26	as	as	IN
cord-021419-nypnib0h	278	27	the	the	DT
cord-021419-nypnib0h	278	28	substrate	substrate	NN
cord-021419-nypnib0h	278	29	.	.	.
cord-021419-nypnib0h	279	1	Compound	compound	NN
cord-021419-nypnib0h	279	2	 	 	_SP
cord-021419-nypnib0h	279	3	the	the	DT
cord-021419-nypnib0h	279	4	same	same	JJ
cord-021419-nypnib0h	279	5	conditions	condition	NNS
cord-021419-nypnib0h	279	6	as	as	IN
cord-021419-nypnib0h	279	7	those	those	DT
cord-021419-nypnib0h	279	8	used	use	VBN
cord-021419-nypnib0h	279	9	for	for	IN
cord-021419-nypnib0h	279	10	37	37	CD
cord-021419-nypnib0h	279	11	was	be	VBD
cord-021419-nypnib0h	279	12	not	not	RB
cord-021419-nypnib0h	279	13	successful	successful	JJ
cord-021419-nypnib0h	279	14	(	(	-LRB-
cord-021419-nypnib0h	279	15	see	see	VB
cord-021419-nypnib0h	279	16	Scheme	scheme	NN
cord-021419-nypnib0h	279	17	11	11	CD
cord-021419-nypnib0h	279	18	)	)	-RRB-
cord-021419-nypnib0h	279	19	.	.	.
cord-021419-nypnib0h	280	1	40	40	CD
cord-021419-nypnib0h	281	1	Meanwhile	meanwhile	RB
cord-021419-nypnib0h	281	2	,	,	,
cord-021419-nypnib0h	281	3	this	this	DT
cord-021419-nypnib0h	281	4	reaction	reaction	NN
cord-021419-nypnib0h	281	5	with	with	IN
cord-021419-nypnib0h	281	6	another	another	DT
cord-021419-nypnib0h	281	7	amine	amine	NN
cord-021419-nypnib0h	281	8	containing	contain	VBG
cord-021419-nypnib0h	281	9	an	an	DT
cord-021419-nypnib0h	281	10	aminoethyl	aminoethyl	NN
cord-021419-nypnib0h	281	11	spacer	spacer	NN
cord-021419-nypnib0h	281	12	gives	give	VBZ
cord-021419-nypnib0h	281	13	the	the	DT
cord-021419-nypnib0h	281	14	corresponding	correspond	VBG
cord-021419-nypnib0h	281	15	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	281	16	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	281	17	derivative	derivative	NNP
cord-021419-nypnib0h	281	18	39	39	CD
cord-021419-nypnib0h	281	19	(	(	-LRB-
cord-021419-nypnib0h	281	20	see	see	VB
cord-021419-nypnib0h	281	21	Scheme	scheme	NN
cord-021419-nypnib0h	281	22	11	11	CD
cord-021419-nypnib0h	281	23	)	)	-RRB-
cord-021419-nypnib0h	281	24	.	.	.
cord-021419-nypnib0h	282	1	40	40	CD
cord-021419-nypnib0h	283	1	However	however	RB
cord-021419-nypnib0h	283	2	,	,	,
cord-021419-nypnib0h	283	3	the	the	DT
cord-021419-nypnib0h	283	4	elimination	elimination	NN
cord-021419-nypnib0h	283	5	of	of	IN
cord-021419-nypnib0h	283	6	the	the	DT
cord-021419-nypnib0h	283	7	2	2	CD
cord-021419-nypnib0h	283	8	H	h	NN
cord-021419-nypnib0h	283	9	-OAc	-OAc	NNS
cord-021419-nypnib0h	283	10	group	group	NN
cord-021419-nypnib0h	283	11	finally	finally	RB
cord-021419-nypnib0h	283	12	results	result	VBZ
cord-021419-nypnib0h	283	13	in	in	IN
cord-021419-nypnib0h	283	14	the	the	DT
cord-021419-nypnib0h	283	15	decomposition	decomposition	NN
cord-021419-nypnib0h	283	16	of	of	IN
cord-021419-nypnib0h	283	17	the	the	DT
cord-021419-nypnib0h	283	18	deacetyl	deacetyl	NNP
cord-021419-nypnib0h	283	19	derivative	derivative	NNP
cord-021419-nypnib0h	283	20	during	during	IN
cord-021419-nypnib0h	283	21	its	-PRON-	PRP$
cord-021419-nypnib0h	283	22	purification	purification	NN
cord-021419-nypnib0h	283	23	on	on	IN
cord-021419-nypnib0h	283	24	silica	silica	NN
cord-021419-nypnib0h	283	25	gel	gel	NN
cord-021419-nypnib0h	283	26	.	.	.
cord-021419-nypnib0h	284	1	An	an	DT
cord-021419-nypnib0h	284	2	alternative	alternative	JJ
cord-021419-nypnib0h	284	3	procedure	procedure	NN
cord-021419-nypnib0h	284	4	for	for	IN
cord-021419-nypnib0h	284	5	the	the	DT
cord-021419-nypnib0h	284	6	introduction	introduction	NN
cord-021419-nypnib0h	284	7	of	of	IN
cord-021419-nypnib0h	284	8	benzoxaboroles	benzoxaboroles	NNP
cord-021419-nypnib0h	284	9	into	into	IN
cord-021419-nypnib0h	284	10	molecule	molecule	NN
cord-021419-nypnib0h	284	11	30	30	CD
cord-021419-nypnib0h	284	12	using	use	VBG
cord-021419-nypnib0h	284	13	carboxy	carboxy	JJ
cord-021419-nypnib0h	284	14	derivatives	derivative	NNS
cord-021419-nypnib0h	284	15	and	and	CC
cord-021419-nypnib0h	284	16	diaminoalkane	diaminoalkane	NNP
cord-021419-nypnib0h	284	17	spacers	spacer	NNS
cord-021419-nypnib0h	284	18	(	(	-LRB-
cord-021419-nypnib0h	284	19	Scheme	scheme	NN
cord-021419-nypnib0h	284	20	12	12	CD
cord-021419-nypnib0h	284	21	)	)	-RRB-
cord-021419-nypnib0h	284	22	proved	prove	VBD
cord-021419-nypnib0h	284	23	to	to	TO
cord-021419-nypnib0h	284	24	be	be	VB
cord-021419-nypnib0h	284	25	more	more	RBR
cord-021419-nypnib0h	284	26	successful	successful	JJ
cord-021419-nypnib0h	284	27	.	.	.
cord-021419-nypnib0h	285	1	40	40	CD
cord-021419-nypnib0h	286	1	The	the	DT
cord-021419-nypnib0h	286	2	treatment	treatment	NN
cord-021419-nypnib0h	286	3	of	of	IN
cord-021419-nypnib0h	286	4	imidazole	imidazole	JJ
cord-021419-nypnib0h	286	5	derivative	derivative	NN
cord-021419-nypnib0h	286	6	38	38	CD
cord-021419-nypnib0h	286	7	with	with	IN
cord-021419-nypnib0h	286	8	stronger	strong	JJR
cord-021419-nypnib0h	286	9	bases	basis	NNS
cord-021419-nypnib0h	286	10	,	,	,
cord-021419-nypnib0h	286	11	such	such	JJ
cord-021419-nypnib0h	286	12	as	as	IN
cord-021419-nypnib0h	286	13	diaminoethane	diaminoethane	NNP
cord-021419-nypnib0h	286	14	or	or	CC
cord-021419-nypnib0h	286	15	1,3-diaminopropane	1,3-diaminopropane	CD
cord-021419-nypnib0h	286	16	,	,	,
cord-021419-nypnib0h	286	17	in	in	IN
cord-021419-nypnib0h	286	18	the	the	DT
cord-021419-nypnib0h	286	19	presence	presence	NN
cord-021419-nypnib0h	286	20	of	of	IN
cord-021419-nypnib0h	286	21	DBU	DBU	NNP
cord-021419-nypnib0h	286	22	resulted	result	VBD
cord-021419-nypnib0h	286	23	in	in	IN
cord-021419-nypnib0h	286	24	the	the	DT
cord-021419-nypnib0h	286	25	formation	formation	NN
cord-021419-nypnib0h	286	26	of	of	IN
cord-021419-nypnib0h	286	27	aminoalkylcarbamoyl	aminoalkylcarbamoyl	NNP
cord-021419-nypnib0h	286	28	derivatives	derivative	NNS
cord-021419-nypnib0h	286	29	40	40	CD
cord-021419-nypnib0h	286	30	(	(	-LRB-
cord-021419-nypnib0h	286	31	n	n	NN
cord-021419-nypnib0h	286	32	=	=	SYM
cord-021419-nypnib0h	286	33	2	2	CD
cord-021419-nypnib0h	286	34	)	)	-RRB-
cord-021419-nypnib0h	286	35	and	and	CC
cord-021419-nypnib0h	286	36	41	41	CD
cord-021419-nypnib0h	286	37	(	(	-LRB-
cord-021419-nypnib0h	286	38	n	n	NN
cord-021419-nypnib0h	286	39	=	=	SYM
cord-021419-nypnib0h	286	40	3	3	CD
cord-021419-nypnib0h	286	41	)	)	-RRB-
cord-021419-nypnib0h	286	42	.	.	.
cord-021419-nypnib0h	287	1	The	the	DT
cord-021419-nypnib0h	287	2	subsequent	subsequent	JJ
cord-021419-nypnib0h	287	3	acylation	acylation	NN
cord-021419-nypnib0h	287	4	of	of	IN
cord-021419-nypnib0h	287	5	the	the	DT
cord-021419-nypnib0h	287	6	latter	latter	JJ
cord-021419-nypnib0h	287	7	with	with	IN
cord-021419-nypnib0h	287	8	various	various	JJ
cord-021419-nypnib0h	287	9	benzoxaborole	benzoxaborole	JJ
cord-021419-nypnib0h	287	10	acids	acid	NNS
cord-021419-nypnib0h	287	11	under	under	IN
cord-021419-nypnib0h	287	12	standard	standard	JJ
cord-021419-nypnib0h	287	13	conditions	condition	NNS
cord-021419-nypnib0h	287	14	(	(	-LRB-
cord-021419-nypnib0h	287	15	DCC	DCC	NNP
cord-021419-nypnib0h	287	16	,	,	,
cord-021419-nypnib0h	287	17	HOBt	HOBt	NNP
cord-021419-nypnib0h	287	18	)	)	-RRB-
cord-021419-nypnib0h	287	19	gives	give	VBZ
cord-021419-nypnib0h	287	20	a	a	DT
cord-021419-nypnib0h	287	21	series	series	NN
cord-021419-nypnib0h	287	22	of	of	IN
cord-021419-nypnib0h	287	23	acylaminoalkylbenzoxaborole	acylaminoalkylbenzoxaborole	NNP
cord-021419-nypnib0h	287	24	-	-	HYPH
cord-021419-nypnib0h	287	25	containing	contain	VBG
cord-021419-nypnib0h	287	26	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	287	27	derivatives	derivative	NNS
cord-021419-nypnib0h	287	28	of	of	IN
cord-021419-nypnib0h	287	29	11,12-cyclic	11,12-cyclic	NNP
cord-021419-nypnib0h	287	30	carbonate	carbonate	NN
cord-021419-nypnib0h	287	31	,	,	,
cord-021419-nypnib0h	287	32	2	2	CD
cord-021419-nypnib0h	287	33	H	h	NN
cord-021419-nypnib0h	287	34	-OAcazithromycin	-OAcazithromycin	NNS
cord-021419-nypnib0h	287	35	42a	42a	CD
cord-021419-nypnib0h	287	36	±	±	CD
cord-021419-nypnib0h	287	37	44a	44a	CD
cord-021419-nypnib0h	287	38	(	(	-LRB-
cord-021419-nypnib0h	287	39	see	see	VB
cord-021419-nypnib0h	287	40	Scheme	Scheme	NNP
cord-021419-nypnib0h	287	41	12	12	CD
cord-021419-nypnib0h	287	42	)	)	-RRB-
cord-021419-nypnib0h	287	43	.	.	.
cord-021419-nypnib0h	288	1	The	the	DT
cord-021419-nypnib0h	288	2	deacetylation	deacetylation	NN
cord-021419-nypnib0h	288	3	of	of	IN
cord-021419-nypnib0h	288	4	these	these	DT
cord-021419-nypnib0h	288	5	compounds	compound	NNS
cord-021419-nypnib0h	288	6	affords	afford	VBZ
cord-021419-nypnib0h	288	7	the	the	DT
cord-021419-nypnib0h	288	8	corresponding	corresponding	JJ
cord-021419-nypnib0h	288	9	cyclic	cyclic	JJ
cord-021419-nypnib0h	288	10	carbo	carbo	NN
cord-021419-nypnib0h	288	11	-	-	HYPH
cord-021419-nypnib0h	288	12	nates	nate	NNS
cord-021419-nypnib0h	288	13	42b	42b	NNS
cord-021419-nypnib0h	288	14	±	±	NNP
cord-021419-nypnib0h	288	15	44b	44b	NNS
cord-021419-nypnib0h	288	16	containing	contain	VBG
cord-021419-nypnib0h	288	17	the	the	DT
cord-021419-nypnib0h	288	18	free	free	JJ
cord-021419-nypnib0h	288	19	C(2	C(2	NNP
cord-021419-nypnib0h	288	20	H	h	NN
cord-021419-nypnib0h	288	21	)	)	-RRB-
cord-021419-nypnib0h	289	1	7OH	7oh	CD
cord-021419-nypnib0h	289	2	group	group	NN
cord-021419-nypnib0h	289	3	of	of	IN
cord-021419-nypnib0h	289	4	the	the	DT
cord-021419-nypnib0h	289	5	desosamine	desosamine	NNP
cord-021419-nypnib0h	289	6	moiety	moiety	NNP
cord-021419-nypnib0h	290	1	(	(	-LRB-
cord-021419-nypnib0h	290	2	R	r	NN
cord-021419-nypnib0h	290	3	1	1	CD
cord-021419-nypnib0h	290	4	=	=	SYM
cord-021419-nypnib0h	290	5	H	h	NN
cord-021419-nypnib0h	290	6	)	)	-RRB-
cord-021419-nypnib0h	290	7	in	in	IN
cord-021419-nypnib0h	290	8	quantitative	quantitative	JJ
cord-021419-nypnib0h	290	9	yields	yield	NNS
cord-021419-nypnib0h	290	10	.	.	.
cord-021419-nypnib0h	291	1	Compound	compound	NN
cord-021419-nypnib0h	291	2	46b	46b	NNS
cord-021419-nypnib0h	291	3	and	and	CC
cord-021419-nypnib0h	291	4	its	-PRON-	PRP$
cord-021419-nypnib0h	291	5	2	2	CD
cord-021419-nypnib0h	291	6	H	h	NN
cord-021419-nypnib0h	291	7	-OAc	-OAc	NNS
cord-021419-nypnib0h	291	8	analogue	analogue	NN
cord-021419-nypnib0h	291	9	46a	46a	NNS
cord-021419-nypnib0h	291	10	were	be	VBD
cord-021419-nypnib0h	291	11	synthesized	synthesize	VBN
cord-021419-nypnib0h	291	12	from	from	IN
cord-021419-nypnib0h	291	13	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	291	14	2	2	CD
cord-021419-nypnib0h	291	15	H	h	NN
cord-021419-nypnib0h	291	16	-OAc-4	-OAc-4	HYPH
cord-021419-nypnib0h	291	17	HH	HH	NNP
cord-021419-nypnib0h	291	18	-O-1H	-O-1H	:
cord-021419-nypnib0h	291	19	-	-	:
cord-021419-nypnib0h	291	20	imidazole-1-carboxylate	imidazole-1-carboxylate	NNP
cord-021419-nypnib0h	291	21	37	37	CD
cord-021419-nypnib0h	291	22	through	through	IN
cord-021419-nypnib0h	291	23	intermediate	intermediate	JJ
cord-021419-nypnib0h	291	24	2	2	CD
cord-021419-nypnib0h	291	25	H	h	NN
cord-021419-nypnib0h	291	26	-OAc	-OAc	:
cord-021419-nypnib0h	291	27	analogues	analogue	NNS
cord-021419-nypnib0h	291	28	45	45	CD
cord-021419-nypnib0h	292	1	(	(	-LRB-
cord-021419-nypnib0h	292	2	n	n	NN
cord-021419-nypnib0h	292	3	=	=	SYM
cord-021419-nypnib0h	292	4	2	2	CD
cord-021419-nypnib0h	292	5	,	,	,
cord-021419-nypnib0h	292	6	3	3	CD
cord-021419-nypnib0h	292	7	)	)	-RRB-
cord-021419-nypnib0h	293	1	(	(	-LRB-
cord-021419-nypnib0h	293	2	Scheme	scheme	NN
cord-021419-nypnib0h	293	3	13	13	CD
cord-021419-nypnib0h	293	4	)	)	-RRB-
cord-021419-nypnib0h	293	5	.	.	.
cord-021419-nypnib0h	294	1	40	40	CD
cord-021419-nypnib0h	295	1	Therefore	therefore	RB
cord-021419-nypnib0h	295	2	,	,	,
cord-021419-nypnib0h	295	3	the	the	DT
cord-021419-nypnib0h	295	4	synthesis	synthesis	NN
cord-021419-nypnib0h	295	5	of	of	IN
cord-021419-nypnib0h	295	6	compound	compound	NN
cord-021419-nypnib0h	295	7	46a	46a	NNS
cord-021419-nypnib0h	295	8	and	and	CC
cord-021419-nypnib0h	295	9	its	-PRON-	PRP$
cord-021419-nypnib0h	295	10	2	2	CD
cord-021419-nypnib0h	295	11	H	h	NN
cord-021419-nypnib0h	295	12	-OAc	-OAc	NNS
cord-021419-nypnib0h	295	13	analogue	analogue	JJ
cord-021419-nypnib0h	295	14	46b	46b	NNS
cord-021419-nypnib0h	295	15	showed	show	VBD
cord-021419-nypnib0h	295	16	that	that	IN
cord-021419-nypnib0h	295	17	the	the	DT
cord-021419-nypnib0h	295	18	introduction	introduction	NN
cord-021419-nypnib0h	295	19	of	of	IN
cord-021419-nypnib0h	295	20	the	the	DT
cord-021419-nypnib0h	295	21	acylaminoalkylbenzoxaborole	acylaminoalkylbenzoxaborole	NN
cord-021419-nypnib0h	295	22	moiety	moiety	NN
cord-021419-nypnib0h	295	23	can	can	MD
cord-021419-nypnib0h	295	24	be	be	VB
cord-021419-nypnib0h	295	25	accomplished	accomplish	VBN
cord-021419-nypnib0h	295	26	using	use	VBG
cord-021419-nypnib0h	295	27	a	a	DT
cord-021419-nypnib0h	295	28	scheme	scheme	NN
cord-021419-nypnib0h	295	29	described	describe	VBN
cord-021419-nypnib0h	295	30	above	above	RB
cord-021419-nypnib0h	295	31	without	without	IN
cord-021419-nypnib0h	295	32	protection	protection	NN
cord-021419-nypnib0h	295	33	of	of	IN
cord-021419-nypnib0h	295	34	the	the	DT
cord-021419-nypnib0h	295	35	C(11)7OH	C(11)7OH	NNP
cord-021419-nypnib0h	295	36	and	and	CC
cord-021419-nypnib0h	295	37	C(12)7OH	C(12)7OH	NNP
cord-021419-nypnib0h	295	38	groups	group	NNS
cord-021419-nypnib0h	295	39	by	by	IN
cord-021419-nypnib0h	295	40	cyclic	cyclic	JJ
cord-021419-nypnib0h	295	41	carbonate	carbonate	NN
cord-021419-nypnib0h	295	42	.	.	.
cord-021419-nypnib0h	296	1	The	the	DT
cord-021419-nypnib0h	296	2	evaluation	evaluation	NN
cord-021419-nypnib0h	296	3	of	of	IN
cord-021419-nypnib0h	296	4	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	296	5	activity	activity	NN
cord-021419-nypnib0h	296	6	of	of	IN
cord-021419-nypnib0h	296	7	4	4	CD
cord-021419-nypnib0h	296	8	HH	HH	NNP
cord-021419-nypnib0h	296	9	-O	-O	:
cord-021419-nypnib0h	296	10	-	-	HYPH
cord-021419-nypnib0h	296	11	substituted	substitute	VBN
cord-021419-nypnib0h	296	12	derivatives	derivative	NNS
cord-021419-nypnib0h	296	13	39	39	CD
cord-021419-nypnib0h	296	14	,	,	,
cord-021419-nypnib0h	296	15	42a	42a	NN
cord-021419-nypnib0h	296	16	±	±	CD
cord-021419-nypnib0h	296	17	44a	44a	CD
cord-021419-nypnib0h	296	18	(	(	-LRB-
cord-021419-nypnib0h	296	19	n	n	NN
cord-021419-nypnib0h	296	20	=	=	SYM
cord-021419-nypnib0h	296	21	2	2	CD
cord-021419-nypnib0h	296	22	)	)	-RRB-
cord-021419-nypnib0h	296	23	,	,	,
cord-021419-nypnib0h	296	24	42b	42b	NNS
cord-021419-nypnib0h	296	25	±	±	NNP
cord-021419-nypnib0h	296	26	44b	44b	,
cord-021419-nypnib0h	296	27	(	(	-LRB-
cord-021419-nypnib0h	296	28	n	n	NN
cord-021419-nypnib0h	296	29	=	=	SYM
cord-021419-nypnib0h	296	30	2	2	CD
cord-021419-nypnib0h	296	31	,	,	,
cord-021419-nypnib0h	296	32	3	3	CD
cord-021419-nypnib0h	296	33	)	)	-RRB-
cord-021419-nypnib0h	296	34	and	and	CC
cord-021419-nypnib0h	296	35	46b	46b	.
cord-021419-nypnib0h	297	1	(	(	-LRB-
cord-021419-nypnib0h	297	2	n	n	NN
cord-021419-nypnib0h	297	3	=	=	SYM
cord-021419-nypnib0h	297	4	2	2	CD
cord-021419-nypnib0h	297	5	,	,	,
cord-021419-nypnib0h	297	6	3	3	CD
cord-021419-nypnib0h	297	7	)	)	-RRB-
cord-021419-nypnib0h	297	8	compared	compare	VBN
cord-021419-nypnib0h	297	9	with	with	IN
cord-021419-nypnib0h	297	10	that	that	DT
cord-021419-nypnib0h	297	11	of	of	IN
cord-021419-nypnib0h	297	12	compound	compound	NN
cord-021419-nypnib0h	297	13	30	30	CD
cord-021419-nypnib0h	297	14	showed	show	VBD
cord-021419-nypnib0h	297	15	that	that	IN
cord-021419-nypnib0h	297	16	the	the	DT
cord-021419-nypnib0h	297	17	activity	activity	NN
cord-021419-nypnib0h	297	18	of	of	IN
cord-021419-nypnib0h	297	19	compounds	compound	NNS
cord-021419-nypnib0h	297	20	39	39	CD
cord-021419-nypnib0h	297	21	,	,	,
cord-021419-nypnib0h	297	22	42	42	CD
cord-021419-nypnib0h	297	23	±	±	CD
cord-021419-nypnib0h	297	24	44	44	CD
cord-021419-nypnib0h	297	25	and	and	CC
cord-021419-nypnib0h	297	26	46	46	CD
cord-021419-nypnib0h	297	27	against	against	IN
cord-021419-nypnib0h	297	28	Gram	gram	NN
cord-021419-nypnib0h	297	29	-	-	HYPH
cord-021419-nypnib0h	297	30	negative	negative	JJ
cord-021419-nypnib0h	297	31	bacteria	bacteria	NNS
cord-021419-nypnib0h	297	32	(	(	-LRB-
cord-021419-nypnib0h	297	33	5	5	CD
cord-021419-nypnib0h	297	34	isolates	isolate	NNS
cord-021419-nypnib0h	297	35	)	)	-RRB-
cord-021419-nypnib0h	297	36	is	be	VBZ
cord-021419-nypnib0h	297	37	lower	low	JJR
cord-021419-nypnib0h	297	38	than	than	IN
cord-021419-nypnib0h	297	39	that	that	DT
cord-021419-nypnib0h	297	40	against	against	IN
cord-021419-nypnib0h	297	41	Gram	gram	NN
cord-021419-nypnib0h	297	42	-	-	HYPH
cord-021419-nypnib0h	297	43	positive	positive	JJ
cord-021419-nypnib0h	297	44	bacteria	bacteria	NNS
cord-021419-nypnib0h	297	45	(	(	-LRB-
cord-021419-nypnib0h	297	46	8	8	CD
cord-021419-nypnib0h	297	47	isolates	isolate	NNS
cord-021419-nypnib0h	297	48	)	)	-RRB-
cord-021419-nypnib0h	297	49	.	.	.
cord-021419-nypnib0h	298	1	For	for	IN
cord-021419-nypnib0h	298	2	example	example	NN
cord-021419-nypnib0h	298	3	,	,	,
cord-021419-nypnib0h	298	4	the	the	DT
cord-021419-nypnib0h	298	5	activity	activity	NN
cord-021419-nypnib0h	298	6	of	of	IN
cord-021419-nypnib0h	298	7	compounds	compound	NNS
cord-021419-nypnib0h	298	8	39	39	CD
cord-021419-nypnib0h	298	9	,	,	,
cord-021419-nypnib0h	298	10	42a	42a	.
cord-021419-nypnib0h	299	1	(	(	-LRB-
cord-021419-nypnib0h	299	2	n	n	NN
cord-021419-nypnib0h	299	3	=	=	SYM
cord-021419-nypnib0h	299	4	2	2	CD
cord-021419-nypnib0h	299	5	)	)	-RRB-
cord-021419-nypnib0h	299	6	,	,	,
cord-021419-nypnib0h	299	7	43a	43a	.
cord-021419-nypnib0h	300	1	(	(	-LRB-
cord-021419-nypnib0h	300	2	n	n	NN
cord-021419-nypnib0h	300	3	=	=	SYM
cord-021419-nypnib0h	300	4	3	3	CD
cord-021419-nypnib0h	300	5	)	)	-RRB-
cord-021419-nypnib0h	300	6	and	and	CC
cord-021419-nypnib0h	300	7	42b	42b	NNS
cord-021419-nypnib0h	300	8	(	(	-LRB-
cord-021419-nypnib0h	300	9	n	n	NN
cord-021419-nypnib0h	300	10	=	=	SYM
cord-021419-nypnib0h	300	11	3	3	CD
cord-021419-nypnib0h	300	12	)	)	-RRB-
cord-021419-nypnib0h	300	13	against	against	IN
cord-021419-nypnib0h	300	14	the	the	DT
cord-021419-nypnib0h	300	15	Gram	Gram	NNP
cord-021419-nypnib0h	300	16	-	-	HYPH
cord-021419-nypnib0h	300	17	positive	positive	JJ
cord-021419-nypnib0h	300	18	strains	strain	NNS
cord-021419-nypnib0h	300	19	Streptococcus	streptococcus	NN
cord-021419-nypnib0h	300	20	pyogenes	pyogene	NNS
cord-021419-nypnib0h	300	21	ATCC	ATCC	NNP
cord-021419-nypnib0h	300	22	19615	19615	CD
cord-021419-nypnib0h	300	23	and	and	CC
cord-021419-nypnib0h	300	24	Propionibacterium	propionibacterium	NN
cord-021419-nypnib0h	300	25	acnes	acne	NNS
cord-021419-nypnib0h	300	26	ATCC	ATCC	NNP
cord-021419-nypnib0h	300	27	6919	6919	CD
cord-021419-nypnib0h	300	28	is	be	VBZ
cord-021419-nypnib0h	300	29	comparable	comparable	JJ
cord-021419-nypnib0h	300	30	with	with	IN
cord-021419-nypnib0h	300	31	that	that	DT
cord-021419-nypnib0h	300	32	of	of	IN
cord-021419-nypnib0h	300	33	the	the	DT
cord-021419-nypnib0h	300	34	starting	starting	NN
cord-021419-nypnib0h	300	35	com-	com-	NN
cord-021419-nypnib0h	300	36	pound	pound	NN
cord-021419-nypnib0h	300	37	30	30	CD
cord-021419-nypnib0h	300	38	,	,	,
cord-021419-nypnib0h	300	39	while	while	IN
cord-021419-nypnib0h	300	40	conjugates	conjugate	NNS
cord-021419-nypnib0h	300	41	42b	42b	NNS
cord-021419-nypnib0h	300	42	(	(	-LRB-
cord-021419-nypnib0h	300	43	n	n	NN
cord-021419-nypnib0h	300	44	=	=	SYM
cord-021419-nypnib0h	300	45	3	3	CD
cord-021419-nypnib0h	300	46	)	)	-RRB-
cord-021419-nypnib0h	300	47	,	,	,
cord-021419-nypnib0h	300	48	43a	43a	,
cord-021419-nypnib0h	300	49	(	(	-LRB-
cord-021419-nypnib0h	300	50	n	n	NN
cord-021419-nypnib0h	300	51	=	=	SYM
cord-021419-nypnib0h	300	52	2	2	CD
cord-021419-nypnib0h	300	53	)	)	-RRB-
cord-021419-nypnib0h	300	54	,	,	,
cord-021419-nypnib0h	300	55	43b	43b	CD
cord-021419-nypnib0h	300	56	(	(	-LRB-
cord-021419-nypnib0h	300	57	n	n	NN
cord-021419-nypnib0h	300	58	=	=	SYM
cord-021419-nypnib0h	300	59	2	2	CD
cord-021419-nypnib0h	300	60	)	)	-RRB-
cord-021419-nypnib0h	300	61	and	and	CC
cord-021419-nypnib0h	300	62	44b	44b	.
cord-021419-nypnib0h	300	63	(	(	-LRB-
cord-021419-nypnib0h	300	64	n	n	NN
cord-021419-nypnib0h	300	65	=	=	SYM
cord-021419-nypnib0h	300	66	2	2	CD
cord-021419-nypnib0h	300	67	)	)	-RRB-
cord-021419-nypnib0h	300	68	are	be	VBP
cord-021419-nypnib0h	300	69	more	more	RBR
cord-021419-nypnib0h	300	70	effective	effective	JJ
cord-021419-nypnib0h	300	71	than	than	IN
cord-021419-nypnib0h	300	72	compound	compound	NN
cord-021419-nypnib0h	300	73	30	30	CD
cord-021419-nypnib0h	300	74	against	against	IN
cord-021419-nypnib0h	300	75	the	the	DT
cord-021419-nypnib0h	300	76	strains	strain	NNS
cord-021419-nypnib0h	300	77	Streptococcus	streptococcus	NN
cord-021419-nypnib0h	300	78	pneumoniae	pneumoniae	NN
cord-021419-nypnib0h	300	79	ATCC	ATCC	NNP
cord-021419-nypnib0h	300	80	49619	49619	CD
cord-021419-nypnib0h	300	81	or	or	CC
cord-021419-nypnib0h	300	82	Enterococcus	Enterococcus	NNP
cord-021419-nypnib0h	300	83	faecium	faecium	NN
cord-021419-nypnib0h	300	84	.	.	.
cord-021419-nypnib0h	301	1	The	the	DT
cord-021419-nypnib0h	301	2	presence	presence	NN
cord-021419-nypnib0h	301	3	of	of	IN
cord-021419-nypnib0h	301	4	the	the	DT
cord-021419-nypnib0h	301	5	2	2	CD
cord-021419-nypnib0h	301	6	H	h	NN
cord-021419-nypnib0h	301	7	-OAc	-OAc	NNS
cord-021419-nypnib0h	301	8	group	group	NN
cord-021419-nypnib0h	301	9	or	or	CC
cord-021419-nypnib0h	301	10	11,12-cyclic	11,12-cyclic	CD
cord-021419-nypnib0h	301	11	carbonate	carbonate	NN
cord-021419-nypnib0h	301	12	in	in	IN
cord-021419-nypnib0h	301	13	analogous	analogous	JJ
cord-021419-nypnib0h	301	14	hybrid	hybrid	JJ
cord-021419-nypnib0h	301	15	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	301	16	was	be	VBD
cord-021419-nypnib0h	301	17	found	find	VBN
cord-021419-nypnib0h	301	18	to	to	TO
cord-021419-nypnib0h	301	19	have	have	VB
cord-021419-nypnib0h	301	20	almost	almost	RB
cord-021419-nypnib0h	301	21	no	no	DT
cord-021419-nypnib0h	301	22	effect	effect	NN
cord-021419-nypnib0h	301	23	on	on	IN
cord-021419-nypnib0h	301	24	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	301	25	activity	activity	NN
cord-021419-nypnib0h	301	26	.	.	.
cord-021419-nypnib0h	302	1	For	for	IN
cord-021419-nypnib0h	302	2	compounds	compound	NNS
cord-021419-nypnib0h	302	3	42a	42a	,
cord-021419-nypnib0h	302	4	(	(	-LRB-
cord-021419-nypnib0h	302	5	n	n	NN
cord-021419-nypnib0h	302	6	=	=	SYM
cord-021419-nypnib0h	302	7	2	2	CD
cord-021419-nypnib0h	302	8	,	,	,
cord-021419-nypnib0h	302	9	3	3	CD
cord-021419-nypnib0h	302	10	)	)	-RRB-
cord-021419-nypnib0h	302	11	,	,	,
cord-021419-nypnib0h	302	12	43a	43a	,
cord-021419-nypnib0h	302	13	(	(	-LRB-
cord-021419-nypnib0h	302	14	n	n	NN
cord-021419-nypnib0h	302	15	=	=	SYM
cord-021419-nypnib0h	302	16	2	2	CD
cord-021419-nypnib0h	302	17	,	,	,
cord-021419-nypnib0h	302	18	3	3	CD
cord-021419-nypnib0h	302	19	)	)	-RRB-
cord-021419-nypnib0h	302	20	,	,	,
cord-021419-nypnib0h	302	21	44a	44a	CD
cord-021419-nypnib0h	302	22	(	(	-LRB-
cord-021419-nypnib0h	302	23	n	n	NN
cord-021419-nypnib0h	302	24	=	=	SYM
cord-021419-nypnib0h	302	25	3	3	CD
cord-021419-nypnib0h	302	26	)	)	-RRB-
cord-021419-nypnib0h	302	27	,	,	,
cord-021419-nypnib0h	302	28	42b	42b	NNS
cord-021419-nypnib0h	302	29	±	±	NNP
cord-021419-nypnib0h	302	30	44b	44b	,
cord-021419-nypnib0h	302	31	(	(	-LRB-
cord-021419-nypnib0h	302	32	n	n	NN
cord-021419-nypnib0h	302	33	=	=	SYM
cord-021419-nypnib0h	302	34	3	3	CD
cord-021419-nypnib0h	302	35	)	)	-RRB-
cord-021419-nypnib0h	302	36	and	and	CC
cord-021419-nypnib0h	302	37	46b	46b	NNS
cord-021419-nypnib0h	302	38	(	(	-LRB-
cord-021419-nypnib0h	302	39	n	n	NN
cord-021419-nypnib0h	302	40	=	=	SYM
cord-021419-nypnib0h	302	41	2	2	CD
cord-021419-nypnib0h	302	42	,	,	,
cord-021419-nypnib0h	302	43	3	3	CD
cord-021419-nypnib0h	302	44	)	)	-RRB-
cord-021419-nypnib0h	302	45	,	,	,
cord-021419-nypnib0h	302	46	the	the	DT
cord-021419-nypnib0h	302	47	mechanism	mechanism	NN
cord-021419-nypnib0h	302	48	of	of	IN
cord-021419-nypnib0h	302	49	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	302	50	activity	activity	NN
cord-021419-nypnib0h	302	51	was	be	VBD
cord-021419-nypnib0h	302	52	studied	study	VBN
cord-021419-nypnib0h	302	53	using	use	VBG
cord-021419-nypnib0h	302	54	the	the	DT
cord-021419-nypnib0h	302	55	pRFPCER	pRFPCER	NNP
cord-021419-nypnib0h	302	56	-	-	HYPH
cord-021419-nypnib0h	302	57	TrpL2A	TrpL2A	NNP
cord-021419-nypnib0h	302	58	reporter	reporter	NN
cord-021419-nypnib0h	302	59	construct	construct	NN
cord-021419-nypnib0h	302	60	,	,	,
cord-021419-nypnib0h	302	61	which	which	WDT
cord-021419-nypnib0h	302	62	responds	respond	VBZ
cord-021419-nypnib0h	302	63	to	to	IN
cord-021419-nypnib0h	302	64	inhibitors	inhibitor	NNS
cord-021419-nypnib0h	302	65	of	of	IN
cord-021419-nypnib0h	302	66	translocation	translocation	NN
cord-021419-nypnib0h	302	67	of	of	IN
cord-021419-nypnib0h	302	68	the	the	DT
cord-021419-nypnib0h	302	69	ribosome	ribosome	NN
cord-021419-nypnib0h	302	70	along	along	IN
cord-021419-nypnib0h	302	71	the	the	DT
cord-021419-nypnib0h	302	72	matrix	matrix	NN
cord-021419-nypnib0h	302	73	nucleic	nucleic	JJ
cord-021419-nypnib0h	302	74	acid	acid	NN
cord-021419-nypnib0h	302	75	(	(	-LRB-
cord-021419-nypnib0h	302	76	mRNA	mrna	NN
cord-021419-nypnib0h	302	77	)	)	-RRB-
cord-021419-nypnib0h	302	78	.	.	.
cord-021419-nypnib0h	303	1	40	40	CD
cord-021419-nypnib0h	304	1	All	all	DT
cord-021419-nypnib0h	304	2	compounds	compound	NNS
cord-021419-nypnib0h	304	3	were	be	VBD
cord-021419-nypnib0h	304	4	found	find	VBN
cord-021419-nypnib0h	304	5	to	to	TO
cord-021419-nypnib0h	304	6	inhibit	inhibit	VB
cord-021419-nypnib0h	304	7	the	the	DT
cord-021419-nypnib0h	304	8	peptide	peptide	NN
cord-021419-nypnib0h	304	9	chain	chain	NN
cord-021419-nypnib0h	304	10	growth	growth	NN
cord-021419-nypnib0h	304	11	at	at	IN
cord-021419-nypnib0h	304	12	the	the	DT
cord-021419-nypnib0h	304	13	exit	exit	NN
cord-021419-nypnib0h	304	14	from	from	IN
cord-021419-nypnib0h	304	15	the	the	DT
cord-021419-nypnib0h	304	16	ribosome	ribosome	NN
cord-021419-nypnib0h	304	17	tunnel	tunnel	NN
cord-021419-nypnib0h	304	18	like	like	IN
cord-021419-nypnib0h	304	19	typical	typical	JJ
cord-021419-nypnib0h	304	20	macrolide	macrolide	JJ
cord-021419-nypnib0h	304	21	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	304	22	.	.	.
cord-021419-nypnib0h	305	1	It	-PRON-	PRP
cord-021419-nypnib0h	305	2	is	be	VBZ
cord-021419-nypnib0h	305	3	worth	worth	JJ
cord-021419-nypnib0h	305	4	noting	note	VBG
cord-021419-nypnib0h	305	5	that	that	IN
cord-021419-nypnib0h	305	6	one	one	CD
cord-021419-nypnib0h	305	7	of	of	IN
cord-021419-nypnib0h	305	8	the	the	DT
cord-021419-nypnib0h	305	9	starting	start	VBG
cord-021419-nypnib0h	305	10	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	305	11	acids	acid	NNS
cord-021419-nypnib0h	305	12	,	,	,
cord-021419-nypnib0h	305	13	3-(1-hydroxy-1,3-dihydrobenzo[c	3-(1-hydroxy-1,3-dihydrobenzo[c	LS
cord-021419-nypnib0h	305	14	]	]	-RRB-
cord-021419-nypnib0h	305	15	[	[	-LRB-
cord-021419-nypnib0h	305	16	1	1	CD
cord-021419-nypnib0h	305	17	,	,	,
cord-021419-nypnib0h	305	18	2	2	CD
cord-021419-nypnib0h	305	19	]	]	-RRB-
cord-021419-nypnib0h	305	20	oxaborol-7-yl)propanoic	oxaborol-7-yl)propanoic	NN
cord-021419-nypnib0h	305	21	acid	acid	NN
cord-021419-nypnib0h	305	22	(	(	-LRB-
cord-021419-nypnib0h	305	23	see	see	VB
cord-021419-nypnib0h	305	24	Schemes	Schemes	NNPS
cord-021419-nypnib0h	305	25	12	12	CD
cord-021419-nypnib0h	305	26	and	and	CC
cord-021419-nypnib0h	305	27	13	13	CD
cord-021419-nypnib0h	305	28	,	,	,
cord-021419-nypnib0h	305	29	marked	mark	VBN
cord-021419-nypnib0h	305	30	with	with	IN
cord-021419-nypnib0h	305	31	an	an	DT
cord-021419-nypnib0h	305	32	asterisk	asterisk	NN
cord-021419-nypnib0h	305	33	)	)	-RRB-
cord-021419-nypnib0h	305	34	,	,	,
cord-021419-nypnib0h	305	35	also	also	RB
cord-021419-nypnib0h	305	36	exhibited	exhibit	VBD
cord-021419-nypnib0h	305	37	activity	activity	NN
cord-021419-nypnib0h	305	38	in	in	IN
cord-021419-nypnib0h	305	39	this	this	DT
cord-021419-nypnib0h	305	40	assay	assay	NN
cord-021419-nypnib0h	305	41	.	.	.
cord-021419-nypnib0h	306	1	3.3	3.3	CD
cord-021419-nypnib0h	306	2	.	.	.
cord-021419-nypnib0h	307	1	Azithromycin	Azithromycin	NNP
cord-021419-nypnib0h	307	2	±	±	NNP
cord-021419-nypnib0h	307	3	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	307	4	conjugates	conjugate	NNS
cord-021419-nypnib0h	307	5	at	at	IN
cord-021419-nypnib0h	307	6	the	the	DT
cord-021419-nypnib0h	307	7	11-OH	11-oh	CD
cord-021419-nypnib0h	307	8	group	group	NN
cord-021419-nypnib0h	307	9	of	of	IN
cord-021419-nypnib0h	307	10	the	the	DT
cord-021419-nypnib0h	307	11	aglycone	aglycone	JJ
cord-021419-nypnib0h	307	12	11,12-Cyclic	11,12-cyclic	CD
cord-021419-nypnib0h	307	13	carbonate	carbonate	NN
cord-021419-nypnib0h	307	14	can	can	MD
cord-021419-nypnib0h	307	15	be	be	VB
cord-021419-nypnib0h	307	16	used	use	VBN
cord-021419-nypnib0h	307	17	not	not	RB
cord-021419-nypnib0h	307	18	only	only	RB
cord-021419-nypnib0h	307	19	as	as	IN
cord-021419-nypnib0h	307	20	the	the	DT
cord-021419-nypnib0h	307	21	protecting	protect	VBG
cord-021419-nypnib0h	307	22	group	group	NN
cord-021419-nypnib0h	307	23	for	for	IN
cord-021419-nypnib0h	307	24	two	two	CD
cord-021419-nypnib0h	307	25	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	307	26	groups	group	NNS
cord-021419-nypnib0h	307	27	but	but	CC
cord-021419-nypnib0h	307	28	also	also	RB
cord-021419-nypnib0h	307	29	as	as	IN
cord-021419-nypnib0h	307	30	the	the	DT
cord-021419-nypnib0h	307	31	activated	activate	VBN
cord-021419-nypnib0h	307	32	group	group	NN
cord-021419-nypnib0h	307	33	to	to	TO
cord-021419-nypnib0h	307	34	introduce	introduce	VB
cord-021419-nypnib0h	307	35	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	307	36	substituents	substituent	NNS
cord-021419-nypnib0h	307	37	at	at	IN
cord-021419-nypnib0h	307	38	the	the	DT
cord-021419-nypnib0h	307	39	11	11	CD
cord-021419-nypnib0h	307	40	position	position	NN
cord-021419-nypnib0h	307	41	of	of	IN
cord-021419-nypnib0h	307	42	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	307	43	.	.	.
cord-021419-nypnib0h	308	1	41	41	CD
cord-021419-nypnib0h	309	1	The	the	DT
cord-021419-nypnib0h	309	2	reaction	reaction	NN
cord-021419-nypnib0h	309	3	of	of	IN
cord-021419-nypnib0h	309	4	11,12-cyclic	11,12-cyclic	NNP
cord-021419-nypnib0h	309	5	carbonate	carbonate	NN
cord-021419-nypnib0h	309	6	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	309	7	2	2	CD
cord-021419-nypnib0h	309	8	H	h	NN
cord-021419-nypnib0h	309	9	-OAc	-OAc	:
cord-021419-nypnib0h	309	10	derivative	derivative	JJ
cord-021419-nypnib0h	309	11	47	47	CD
cord-021419-nypnib0h	309	12	,	,	,
cord-021419-nypnib0h	309	13	which	which	WDT
cord-021419-nypnib0h	309	14	was	be	VBD
cord-021419-nypnib0h	309	15	generated	generate	VBN
cord-021419-nypnib0h	309	16	from	from	IN
cord-021419-nypnib0h	309	17	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	309	18	(	(	-LRB-
cord-021419-nypnib0h	309	19	30	30	CD
cord-021419-nypnib0h	309	20	)	)	-RRB-
cord-021419-nypnib0h	309	21	in	in	IN
cord-021419-nypnib0h	309	22	two	two	CD
cord-021419-nypnib0h	309	23	steps	step	NNS
cord-021419-nypnib0h	309	24	(	(	-LRB-
cord-021419-nypnib0h	309	25	treatment	treatment	NN
cord-021419-nypnib0h	309	26	with	with	IN
cord-021419-nypnib0h	309	27	ethylene	ethylene	NN
cord-021419-nypnib0h	309	28	carbonate	carbonate	NN
cord-021419-nypnib0h	309	29	followed	follow	VBN
cord-021419-nypnib0h	309	30	by	by	IN
cord-021419-nypnib0h	309	31	acylation	acylation	NN
cord-021419-nypnib0h	309	32	of	of	IN
cord-021419-nypnib0h	309	33	the	the	DT
cord-021419-nypnib0h	309	34	2	2	CD
cord-021419-nypnib0h	309	35	H	H	NNP
cord-021419-nypnib0h	309	36	-O	-O	HYPH
cord-021419-nypnib0h	309	37	group	group	NN
cord-021419-nypnib0h	309	38	of	of	IN
cord-021419-nypnib0h	309	39	the	the	DT
cord-021419-nypnib0h	309	40	desosamine	desosamine	NNP
cord-021419-nypnib0h	309	41	moiety	moiety	NNP
cord-021419-nypnib0h	309	42	)	)	-RRB-
cord-021419-nypnib0h	309	43	,	,	,
cord-021419-nypnib0h	309	44	with	with	IN
cord-021419-nypnib0h	309	45	diaminoalkane	diaminoalkane	NNP
cord-021419-nypnib0h	309	46	gave	give	VBD
cord-021419-nypnib0h	309	47	2	2	CD
cord-021419-nypnib0h	309	48	H	h	NN
cord-021419-nypnib0h	309	49	-Oacetylazithromycin	-oacetylazithromycin	NN
cord-021419-nypnib0h	309	50	11-aminoalkylcarbamates	11-aminoalkylcarbamates	CD
cord-021419-nypnib0h	309	51	48	48	CD
cord-021419-nypnib0h	310	1	(	(	-LRB-
cord-021419-nypnib0h	310	2	n	n	NN
cord-021419-nypnib0h	310	3	=	=	SYM
cord-021419-nypnib0h	310	4	3	3	CD
cord-021419-nypnib0h	310	5	,	,	,
cord-021419-nypnib0h	310	6	5	5	CD
cord-021419-nypnib0h	310	7	)	)	-RRB-
cord-021419-nypnib0h	310	8	(	(	-LRB-
cord-021419-nypnib0h	310	9	Scheme	scheme	NN
cord-021419-nypnib0h	310	10	14	14	CD
cord-021419-nypnib0h	310	11	)	)	-RRB-
cord-021419-nypnib0h	310	12	.	.	.
cord-021419-nypnib0h	311	1	The	the	DT
cord-021419-nypnib0h	311	2	acylation	acylation	NN
cord-021419-nypnib0h	311	3	of	of	IN
cord-021419-nypnib0h	311	4	compound	compound	NN
cord-021419-nypnib0h	311	5	48	48	CD
cord-021419-nypnib0h	311	6	with	with	IN
cord-021419-nypnib0h	311	7	benzoxaborole	benzoxaborole	JJ
cord-021419-nypnib0h	311	8	acids	acid	NNS
cord-021419-nypnib0h	311	9	under	under	IN
cord-021419-nypnib0h	311	10	standard	standard	JJ
cord-021419-nypnib0h	311	11	conditions	condition	NNS
cord-021419-nypnib0h	311	12	(	(	-LRB-
cord-021419-nypnib0h	311	13	DCC	DCC	NNP
cord-021419-nypnib0h	311	14	,	,	,
cord-021419-nypnib0h	311	15	HOBt	HOBt	NNP
cord-021419-nypnib0h	311	16	)	)	-RRB-
cord-021419-nypnib0h	311	17	produced	produce	VBD
cord-021419-nypnib0h	311	18	a	a	DT
cord-021419-nypnib0h	311	19	series	series	NN
cord-021419-nypnib0h	311	20	of	of	IN
cord-021419-nypnib0h	311	21	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	311	22	2	2	CD
cord-021419-nypnib0h	311	23	H	H	NNP
cord-021419-nypnib0h	311	24	-OAc	-OAc	:
cord-021419-nypnib0h	311	25	derivatives	derivative	NNS
cord-021419-nypnib0h	311	26	49a	49a	CD
cord-021419-nypnib0h	311	27	±	±	CD
cord-021419-nypnib0h	311	28	51a	51a	NNS
cord-021419-nypnib0h	311	29	.	.	.
cord-021419-nypnib0h	312	1	The	the	DT
cord-021419-nypnib0h	312	2	deacetylation	deacetylation	NN
cord-021419-nypnib0h	312	3	of	of	IN
cord-021419-nypnib0h	312	4	these	these	DT
cord-021419-nypnib0h	312	5	compounds	compound	NNS
cord-021419-nypnib0h	312	6	afforded	afford	VBN
cord-021419-nypnib0h	312	7	target	target	NN
cord-021419-nypnib0h	312	8	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	312	9	derivatives	derivative	NNS
cord-021419-nypnib0h	312	10	49b	49b	CD
cord-021419-nypnib0h	312	11	±	±	CD
cord-021419-nypnib0h	312	12	51b	51b	NNS
cord-021419-nypnib0h	312	13	.	.	.
cord-021419-nypnib0h	313	1	New	new	JJ
cord-021419-nypnib0h	313	2	hybrid	hybrid	JJ
cord-021419-nypnib0h	313	3	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	313	4	49b	49b	-RRB-
cord-021419-nypnib0h	313	5	±	±	CD
cord-021419-nypnib0h	313	6	51b	51b	NNS
cord-021419-nypnib0h	313	7	exhibit	exhibit	VBP
cord-021419-nypnib0h	313	8	broader	broad	JJR
cord-021419-nypnib0h	313	9	-	-	HYPH
cord-021419-nypnib0h	313	10	spectrum	spectrum	NN
cord-021419-nypnib0h	313	11	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	313	12	activity	activity	NN
cord-021419-nypnib0h	313	13	against	against	IN
cord-021419-nypnib0h	313	14	Gram	gram	NN
cord-021419-nypnib0h	313	15	-	-	HYPH
cord-021419-nypnib0h	313	16	positive	positive	JJ
cord-021419-nypnib0h	313	17	and	and	CC
cord-021419-nypnib0h	313	18	Gram	gram	NN
cord-021419-nypnib0h	313	19	-	-	HYPH
cord-021419-nypnib0h	313	20	negative	negative	JJ
cord-021419-nypnib0h	313	21	bacteria	bacteria	NNS
cord-021419-nypnib0h	313	22	compared	compare	VBN
cord-021419-nypnib0h	313	23	to	to	IN
cord-021419-nypnib0h	313	24	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	313	25	(	(	-LRB-
cord-021419-nypnib0h	313	26	30	30	CD
cord-021419-nypnib0h	313	27	)	)	-RRB-
cord-021419-nypnib0h	313	28	and	and	CC
cord-021419-nypnib0h	313	29	tobramycin	tobramycin	NNS
cord-021419-nypnib0h	313	30	.	.	.
cord-021419-nypnib0h	314	1	Compound	compound	NN
cord-021419-nypnib0h	314	2	50b	50b	NNS
cord-021419-nypnib0h	314	3	proved	prove	VBD
cord-021419-nypnib0h	314	4	to	to	TO
cord-021419-nypnib0h	314	5	be	be	VB
cord-021419-nypnib0h	314	6	the	the	DT
cord-021419-nypnib0h	314	7	most	most	RBS
cord-021419-nypnib0h	314	8	effective	effective	JJ
cord-021419-nypnib0h	314	9	compound	compound	NN
cord-021419-nypnib0h	314	10	in	in	IN
cord-021419-nypnib0h	314	11	this	this	DT
cord-021419-nypnib0h	314	12	series	series	NN
cord-021419-nypnib0h	314	13	,	,	,
cord-021419-nypnib0h	314	14	but	but	CC
cord-021419-nypnib0h	314	15	its	-PRON-	PRP$
cord-021419-nypnib0h	314	16	activity	activity	NN
cord-021419-nypnib0h	314	17	is	be	VBZ
cord-021419-nypnib0h	314	18	lower	low	JJR
cord-021419-nypnib0h	314	19	than	than	IN
cord-021419-nypnib0h	314	20	that	that	DT
cord-021419-nypnib0h	314	21	of	of	IN
cord-021419-nypnib0h	314	22	compound	compound	NN
cord-021419-nypnib0h	314	23	30	30	CD
cord-021419-nypnib0h	314	24	.	.	.
cord-021419-nypnib0h	315	1	The	the	DT
cord-021419-nypnib0h	315	2	modified	modify	VBN
cord-021419-nypnib0h	315	3	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	315	4	do	do	VBP
cord-021419-nypnib0h	315	5	not	not	RB
cord-021419-nypnib0h	315	6	overcome	overcome	VB
cord-021419-nypnib0h	315	7	the	the	DT
cord-021419-nypnib0h	315	8	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	315	9	resistance	resistance	NN
cord-021419-nypnib0h	315	10	in	in	IN
cord-021419-nypnib0h	315	11	MRSA	MRSA	NNP
cord-021419-nypnib0h	315	12	strains	strain	NNS
cord-021419-nypnib0h	315	13	(	(	-LRB-
cord-021419-nypnib0h	315	14	strain	strain	NN
cord-021419-nypnib0h	315	15	ATCC	ATCC	NNP
cord-021419-nypnib0h	315	16	33591	33591	CD
cord-021419-nypnib0h	315	17	)	)	-RRB-
cord-021419-nypnib0h	315	18	.	.	.
cord-021419-nypnib0h	316	1	Higher	high	JJR
cord-021419-nypnib0h	316	2	activity	activity	NN
cord-021419-nypnib0h	316	3	of	of	IN
cord-021419-nypnib0h	316	4	these	these	DT
cord-021419-nypnib0h	316	5	three	three	CD
cord-021419-nypnib0h	316	6	compounds	compound	NNS
cord-021419-nypnib0h	316	7	against	against	IN
cord-021419-nypnib0h	316	8	the	the	DT
cord-021419-nypnib0h	316	9	sensitive	sensitive	JJ
cord-021419-nypnib0h	316	10	strain	strain	NN
cord-021419-nypnib0h	316	11	S.	S.	NNP
cord-021419-nypnib0h	316	12	pneumonia	pneumonia	NN
cord-021419-nypnib0h	316	13	ATCC	ATCC	NNP
cord-021419-nypnib0h	316	14	6301	6301	CD
cord-021419-nypnib0h	316	15	compared	compare	VBN
cord-021419-nypnib0h	316	16	to	to	IN
cord-021419-nypnib0h	316	17	tobramycin	tobramycin	NNS
cord-021419-nypnib0h	316	18	(	(	-LRB-
cord-021419-nypnib0h	316	19	MIC	MIC	NNP
cord-021419-nypnib0h	316	20	is	be	VBZ
cord-021419-nypnib0h	316	21	40.06	40.06	CD
cord-021419-nypnib0h	316	22	±	±	CD
cord-021419-nypnib0h	316	23	0.25	0.25	CD
cord-021419-nypnib0h	316	24	versus	versus	IN
cord-021419-nypnib0h	316	25	4	4	CD
cord-021419-nypnib0h	316	26	mg	mg	NN
cord-021419-nypnib0h	316	27	mL	mL	NNP
cord-021419-nypnib0h	316	28	71	71	CD
cord-021419-nypnib0h	316	29	)	)	-RRB-
cord-021419-nypnib0h	316	30	is	be	VBZ
cord-021419-nypnib0h	316	31	a	a	DT
cord-021419-nypnib0h	316	32	particularly	particularly	RB
cord-021419-nypnib0h	316	33	valuable	valuable	JJ
cord-021419-nypnib0h	316	34	property	property	NN
cord-021419-nypnib0h	316	35	.	.	.
cord-021419-nypnib0h	317	1	41	41	CD
cord-021419-nypnib0h	317	2	 	 	_SP
cord-021419-nypnib0h	317	3	,	,	,
cord-021419-nypnib0h	317	4	or	or	CC
cord-021419-nypnib0h	317	5	,	,	,
cord-021419-nypnib0h	317	6	or	or	CC
cord-021419-nypnib0h	317	7	,	,	,
cord-021419-nypnib0h	317	8	DCC	DCC	NNP
cord-021419-nypnib0h	317	9	,	,	,
cord-021419-nypnib0h	317	10	HOBt	HOBt	NNP
cord-021419-nypnib0h	318	1	;	;	:
cord-021419-nypnib0h	318	2	DCC	DCC	NNP
cord-021419-nypnib0h	318	3	is	be	VBZ
cord-021419-nypnib0h	318	4	N	N	NNP
cord-021419-nypnib0h	318	5	,	,	,
cord-021419-nypnib0h	318	6	N	N	NNP
cord-021419-nypnib0h	318	7	H	h	NN
cord-021419-nypnib0h	318	8	-dicyclohexyl	-dicyclohexyl	NN
cord-021419-nypnib0h	318	9	carbodiimide	carbodiimide	NN
cord-021419-nypnib0h	318	10	,	,	,
cord-021419-nypnib0h	318	11	HOBt	HOBt	NNP
cord-021419-nypnib0h	318	12	is	be	VBZ
cord-021419-nypnib0h	318	13	1-hydroxybenzotriazole	1-hydroxybenzotriazole	CD
cord-021419-nypnib0h	318	14	;	;	:
cord-021419-nypnib0h	318	15	In	in	IN
cord-021419-nypnib0h	318	16	the	the	DT
cord-021419-nypnib0h	318	17	former	former	JJ
cord-021419-nypnib0h	318	18	case	case	NN
cord-021419-nypnib0h	318	19	,	,	,
cord-021419-nypnib0h	318	20	the	the	DT
cord-021419-nypnib0h	318	21	reaction	reaction	NN
cord-021419-nypnib0h	318	22	of	of	IN
cord-021419-nypnib0h	318	23	azithromycin	azithromycin	NN
cord-021419-nypnib0h	318	24	11-aminoalkylcarbamates	11-aminoalkylcarbamates	CD
cord-021419-nypnib0h	318	25	48	48	CD
cord-021419-nypnib0h	319	1	(	(	-LRB-
cord-021419-nypnib0h	319	2	n	n	NN
cord-021419-nypnib0h	319	3	=	=	SYM
cord-021419-nypnib0h	319	4	3	3	CD
cord-021419-nypnib0h	319	5	,	,	,
cord-021419-nypnib0h	319	6	5	5	CD
cord-021419-nypnib0h	319	7	)	)	-RRB-
cord-021419-nypnib0h	319	8	with	with	IN
cord-021419-nypnib0h	319	9	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	319	10	1	1	CD
cord-021419-nypnib0h	319	11	,	,	,
cord-021419-nypnib0h	319	12	3	3	CD
cord-021419-nypnib0h	319	13	or	or	CC
cord-021419-nypnib0h	319	14	13	13	CD
cord-021419-nypnib0h	319	15	in	in	IN
cord-021419-nypnib0h	319	16	the	the	DT
cord-021419-nypnib0h	319	17	presence	presence	NN
cord-021419-nypnib0h	319	18	of	of	IN
cord-021419-nypnib0h	319	19	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	319	20	affords	afford	VBZ
cord-021419-nypnib0h	319	21	the	the	DT
cord-021419-nypnib0h	319	22	corresponding	correspond	VBG
cord-021419-nypnib0h	319	23	derivatives	derivative	NNS
cord-021419-nypnib0h	319	24	of	of	IN
cord-021419-nypnib0h	319	25	vancomycin	vancomycin	NN
cord-021419-nypnib0h	319	26	(	(	-LRB-
cord-021419-nypnib0h	319	27	52	52	CD
cord-021419-nypnib0h	319	28	,	,	,
cord-021419-nypnib0h	319	29	53	53	CD
cord-021419-nypnib0h	319	30	)	)	-RRB-
cord-021419-nypnib0h	319	31	,	,	,
cord-021419-nypnib0h	319	32	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	319	33	(	(	-LRB-
cord-021419-nypnib0h	319	34	54	54	CD
cord-021419-nypnib0h	319	35	)	)	-RRB-
cord-021419-nypnib0h	319	36	or	or	CC
cord-021419-nypnib0h	319	37	the	the	DT
cord-021419-nypnib0h	319	38	teicoplanin	teicoplanin	JJ
cord-021419-nypnib0h	319	39	aglycone	aglycone	NNP
cord-021419-nypnib0h	319	40	(	(	-LRB-
cord-021419-nypnib0h	319	41	55	55	CD
cord-021419-nypnib0h	319	42	,	,	,
cord-021419-nypnib0h	319	43	56	56	CD
cord-021419-nypnib0h	319	44	)	)	-RRB-
cord-021419-nypnib0h	320	1	(	(	-LRB-
cord-021419-nypnib0h	320	2	Scheme	scheme	NN
cord-021419-nypnib0h	320	3	15	15	CD
cord-021419-nypnib0h	320	4	)	)	-RRB-
cord-021419-nypnib0h	320	5	.	.	.
cord-021419-nypnib0h	321	1	42	42	CD
cord-021419-nypnib0h	322	1	In	in	IN
cord-021419-nypnib0h	322	2	the	the	DT
cord-021419-nypnib0h	322	3	latter	latter	JJ
cord-021419-nypnib0h	322	4	case	case	NN
cord-021419-nypnib0h	322	5	,	,	,
cord-021419-nypnib0h	322	6	11,12-cyclic	11,12-cyclic	NNP
cord-021419-nypnib0h	322	7	carbonate	carbonate	NN
cord-021419-nypnib0h	322	8	azithromycin	azithromycin	NN
cord-021419-nypnib0h	322	9	4	4	CD
cord-021419-nypnib0h	322	10	HH	HH	NNP
cord-021419-nypnib0h	322	11	-O	-O	:
cord-021419-nypnib0h	322	12	-	-	HYPH
cord-021419-nypnib0h	322	13	alkylaminocarbamoyl	alkylaminocarbamoyl	JJ
cord-021419-nypnib0h	322	14	derivatives	derivative	NNS
cord-021419-nypnib0h	322	15	40	40	CD
cord-021419-nypnib0h	322	16	and	and	CC
cord-021419-nypnib0h	322	17	41	41	CD
cord-021419-nypnib0h	322	18	are	be	VBP
cord-021419-nypnib0h	322	19	amidated	amidate	VBN
cord-021419-nypnib0h	322	20	with	with	IN
cord-021419-nypnib0h	322	21	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	322	22	1	1	CD
cord-021419-nypnib0h	322	23	,	,	,
cord-021419-nypnib0h	322	24	3	3	CD
cord-021419-nypnib0h	322	25	or	or	CC
cord-021419-nypnib0h	322	26	13	13	CD
cord-021419-nypnib0h	322	27	in	in	IN
cord-021419-nypnib0h	322	28	the	the	DT
cord-021419-nypnib0h	322	29	presence	presence	NN
cord-021419-nypnib0h	322	30	of	of	IN
cord-021419-nypnib0h	322	31	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	323	1	(	(	-LRB-
cord-021419-nypnib0h	323	2	Scheme	scheme	NN
cord-021419-nypnib0h	323	3	16	16	CD
cord-021419-nypnib0h	323	4	)	)	-RRB-
cord-021419-nypnib0h	323	5	.	.	.
cord-021419-nypnib0h	324	1	After	after	IN
cord-021419-nypnib0h	324	2	the	the	DT
cord-021419-nypnib0h	324	3	removal	removal	NN
cord-021419-nypnib0h	324	4	of	of	IN
cord-021419-nypnib0h	324	5	the	the	DT
cord-021419-nypnib0h	324	6	2	2	CD
cord-021419-nypnib0h	324	7	H	H	NNP
cord-021419-nypnib0h	324	8	-O	-O	:
cord-021419-nypnib0h	324	9	-	-	HYPH
cord-021419-nypnib0h	324	10	acetyl	acetyl	NN
cord-021419-nypnib0h	324	11	protecting	protect	VBG
cord-021419-nypnib0h	324	12	group	group	NN
cord-021419-nypnib0h	324	13	from	from	IN
cord-021419-nypnib0h	324	14	compounds	compound	NNS
cord-021419-nypnib0h	324	15	57a	57a	NNS
cord-021419-nypnib0h	324	16	±	±	CD
cord-021419-nypnib0h	324	17	61a	61a	NNS
cord-021419-nypnib0h	324	18	and	and	CC
cord-021419-nypnib0h	324	19	the	the	DT
cord-021419-nypnib0h	324	20	column	column	NN
cord-021419-nypnib0h	324	21	chromatographic	chromatographic	JJ
cord-021419-nypnib0h	324	22	separation	separation	NN
cord-021419-nypnib0h	324	23	on	on	IN
cord-021419-nypnib0h	324	24	silanized	silanized	NNP
cord-021419-nypnib0h	324	25	silica	silica	NN
cord-021419-nypnib0h	324	26	gel	gel	NN
cord-021419-nypnib0h	324	27	followed	follow	VBN
cord-021419-nypnib0h	324	28	by	by	IN
cord-021419-nypnib0h	324	29	Sephadex	Sephadex	NNP
cord-021419-nypnib0h	324	30	LH-20	LH-20	NNP
cord-021419-nypnib0h	324	31	chromatography	chromatography	NN
cord-021419-nypnib0h	324	32	,	,	,
cord-021419-nypnib0h	324	33	five	five	CD
cord-021419-nypnib0h	324	34	new	new	JJ
cord-021419-nypnib0h	324	35	conjugates	conjugate	NNS
cord-021419-nypnib0h	324	36	57b	57b	NNS
cord-021419-nypnib0h	324	37	±	±	NNP
cord-021419-nypnib0h	324	38	61b	61b	NNS
cord-021419-nypnib0h	324	39	were	be	VBD
cord-021419-nypnib0h	324	40	isolated	isolate	VBN
cord-021419-nypnib0h	324	41	in	in	IN
cord-021419-nypnib0h	324	42	35	35	CD
cord-021419-nypnib0h	324	43	%	%	NN
cord-021419-nypnib0h	324	44	±	±	CD
cord-021419-nypnib0h	324	45	45	45	CD
cord-021419-nypnib0h	324	46	%	%	NN
cord-021419-nypnib0h	324	47	yields	yield	NNS
cord-021419-nypnib0h	324	48	based	base	VBN
cord-021419-nypnib0h	324	49	on	on	IN
cord-021419-nypnib0h	324	50	the	the	DT
cord-021419-nypnib0h	324	51	corresponding	corresponding	JJ
cord-021419-nypnib0h	324	52	starting	start	VBG
cord-021419-nypnib0h	324	53	antibiotic	antibiotic	NN
cord-021419-nypnib0h	324	54	.	.	.
cord-021419-nypnib0h	325	1	42	42	CD
cord-021419-nypnib0h	325	2	Antibacterial	antibacterial	JJ
cord-021419-nypnib0h	325	3	activity	activity	NN
cord-021419-nypnib0h	325	4	of	of	IN
cord-021419-nypnib0h	325	5	derivatives	derivative	NNS
cord-021419-nypnib0h	325	6	52	52	CD
cord-021419-nypnib0h	325	7	±	±	CD
cord-021419-nypnib0h	325	8	55	55	CD
cord-021419-nypnib0h	325	9	modified	modify	VBN
cord-021419-nypnib0h	325	10	at	at	IN
cord-021419-nypnib0h	325	11	the	the	DT
cord-021419-nypnib0h	325	12	C(11)7OH	C(11)7OH	NNP
cord-021419-nypnib0h	325	13	group	group	NN
cord-021419-nypnib0h	325	14	of	of	IN
cord-021419-nypnib0h	325	15	the	the	DT
cord-021419-nypnib0h	325	16	aglycone	aglycone	NN
cord-021419-nypnib0h	325	17	was	be	VBD
cord-021419-nypnib0h	325	18	evaluated	evaluate	VBN
cord-021419-nypnib0h	325	19	compared	compare	VBN
cord-021419-nypnib0h	325	20	to	to	IN
cord-021419-nypnib0h	325	21	the	the	DT
cord-021419-nypnib0h	325	22	starting	start	VBG
cord-021419-nypnib0h	325	23	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	325	24	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	325	25	(	(	-LRB-
cord-021419-nypnib0h	325	26	1	1	CD
cord-021419-nypnib0h	325	27	)	)	-RRB-
cord-021419-nypnib0h	325	28	and	and	CC
cord-021419-nypnib0h	325	29	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	325	30	(	(	-LRB-
cord-021419-nypnib0h	325	31	30	30	CD
cord-021419-nypnib0h	325	32	)	)	-RRB-
cord-021419-nypnib0h	325	33	on	on	IN
cord-021419-nypnib0h	325	34	a	a	DT
cord-021419-nypnib0h	325	35	panel	panel	NN
cord-021419-nypnib0h	325	36	of	of	IN
cord-021419-nypnib0h	325	37	Gram	gram	NN
cord-021419-nypnib0h	325	38	-	-	HYPH
cord-021419-nypnib0h	325	39	positive	positive	JJ
cord-021419-nypnib0h	325	40	and	and	CC
cord-021419-nypnib0h	325	41	Gramnegative	gramnegative	JJ
cord-021419-nypnib0h	325	42	bacterial	bacterial	JJ
cord-021419-nypnib0h	325	43	strains	strain	NNS
cord-021419-nypnib0h	325	44	(	(	-LRB-
cord-021419-nypnib0h	325	45	8	8	CD
cord-021419-nypnib0h	325	46	and	and	CC
cord-021419-nypnib0h	325	47	3	3	CD
cord-021419-nypnib0h	325	48	strains	strain	NNS
cord-021419-nypnib0h	325	49	,	,	,
cord-021419-nypnib0h	325	50	respectively	respectively	RB
cord-021419-nypnib0h	325	51	)	)	-RRB-
cord-021419-nypnib0h	325	52	.	.	.
cord-021419-nypnib0h	326	1	42	42	CD
cord-021419-nypnib0h	327	1	None	none	NN
cord-021419-nypnib0h	327	2	of	of	IN
cord-021419-nypnib0h	327	3	the	the	DT
cord-021419-nypnib0h	327	4	conjugates	conjugate	NNS
cord-021419-nypnib0h	327	5	exhibited	exhibit	VBD
cord-021419-nypnib0h	327	6	activity	activity	NN
cord-021419-nypnib0h	327	7	against	against	IN
cord-021419-nypnib0h	327	8	Gramnegative	Gramnegative	NNP
cord-021419-nypnib0h	327	9	bacteria	bacteria	NNS
cord-021419-nypnib0h	327	10	,	,	,
cord-021419-nypnib0h	327	11	which	which	WDT
cord-021419-nypnib0h	327	12	attests	attest	VBZ
cord-021419-nypnib0h	327	13	to	to	IN
cord-021419-nypnib0h	327	14	the	the	DT
cord-021419-nypnib0h	327	15	absence	absence	NN
cord-021419-nypnib0h	327	16	of	of	IN
cord-021419-nypnib0h	327	17	the	the	DT
cord-021419-nypnib0h	327	18	effect	effect	NN
cord-021419-nypnib0h	327	19	of	of	IN
cord-021419-nypnib0h	327	20	the	the	DT
cord-021419-nypnib0h	327	21	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	327	22	moiety	moiety	VBZ
cord-021419-nypnib0h	327	23	active	active	JJ
cord-021419-nypnib0h	327	24	against	against	IN
cord-021419-nypnib0h	327	25	Gram	gram	NN
cord-021419-nypnib0h	327	26	-	-	HYPH
cord-021419-nypnib0h	327	27	negative	negative	JJ
cord-021419-nypnib0h	327	28	bacteria	bacteria	NNS
cord-021419-nypnib0h	327	29	.	.	.
cord-021419-nypnib0h	328	1	Generally	generally	RB
cord-021419-nypnib0h	328	2	,	,	,
cord-021419-nypnib0h	328	3	compounds	compound	VBZ
cord-021419-nypnib0h	328	4	52	52	CD
cord-021419-nypnib0h	328	5	±	±	CD
cord-021419-nypnib0h	328	6	55	55	CD
cord-021419-nypnib0h	328	7	display	display	NN
cord-021419-nypnib0h	328	8	similar	similar	JJ
cord-021419-nypnib0h	328	9	or	or	CC
cord-021419-nypnib0h	328	10	somewhat	somewhat	RB
cord-021419-nypnib0h	328	11	lower	low	JJR
cord-021419-nypnib0h	328	12	activity	activity	NN
cord-021419-nypnib0h	328	13	against	against	IN
cord-021419-nypnib0h	328	14	Gram	gram	NN
cord-021419-nypnib0h	328	15	-	-	HYPH
cord-021419-nypnib0h	328	16	positive	positive	JJ
cord-021419-nypnib0h	328	17	bacterial	bacterial	JJ
cord-021419-nypnib0h	328	18	strains	strain	NNS
cord-021419-nypnib0h	328	19	compared	compare	VBN
cord-021419-nypnib0h	328	20	to	to	IN
cord-021419-nypnib0h	328	21	compounds	compound	NNS
cord-021419-nypnib0h	328	22	1	1	CD
cord-021419-nypnib0h	328	23	and(or	and(or	NNP
cord-021419-nypnib0h	328	24	)	)	-RRB-
cord-021419-nypnib0h	328	25	30	30	CD
cord-021419-nypnib0h	328	26	,	,	,
cord-021419-nypnib0h	328	27	the	the	DT
cord-021419-nypnib0h	328	28	activity	activity	NN
cord-021419-nypnib0h	328	29	against	against	IN
cord-021419-nypnib0h	328	30	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	328	31	being	be	VBG
cord-021419-nypnib0h	328	32	higher	high	JJR
cord-021419-nypnib0h	328	33	than	than	IN
cord-021419-nypnib0h	328	34	that	that	DT
cord-021419-nypnib0h	328	35	against	against	IN
cord-021419-nypnib0h	328	36	the	the	DT
cord-021419-nypnib0h	328	37	streptococci	streptococcus	NNS
cord-021419-nypnib0h	328	38	S.	S.	NNP
cord-021419-nypnib0h	328	39	pneumoniae	pneumoniae	NN
cord-021419-nypnib0h	328	40	49619	49619	CD
cord-021419-nypnib0h	328	41	ATCC	ATCC	NNP
cord-021419-nypnib0h	328	42	and	and	CC
cord-021419-nypnib0h	328	43	S.	S.	NNP
cord-021419-nypnib0h	328	44	agalactis	agalactis	NNP
cord-021419-nypnib0h	328	45	52	52	CD
cord-021419-nypnib0h	328	46	-	-	SYM
cord-021419-nypnib0h	328	47	2	2	CD
cord-021419-nypnib0h	328	48	.	.	.
cord-021419-nypnib0h	329	1	Azithromycin	Azithromycin	NNP
cord-021419-nypnib0h	329	2	±	±	NNP
cord-021419-nypnib0h	329	3	teicoplanin	teicoplanin	NN
cord-021419-nypnib0h	329	4	aglycone	aglycone	NN
cord-021419-nypnib0h	329	5	conjugate	conjugate	NN
cord-021419-nypnib0h	329	6	56	56	CD
cord-021419-nypnib0h	329	7	containing	contain	VBG
cord-021419-nypnib0h	329	8	a	a	DT
cord-021419-nypnib0h	329	9	long	long	JJ
cord-021419-nypnib0h	329	10	spacer	spacer	NN
cord-021419-nypnib0h	329	11	(	(	-LRB-
cord-021419-nypnib0h	329	12	n	n	NN
cord-021419-nypnib0h	329	13	=	=	SYM
cord-021419-nypnib0h	329	14	5	5	CD
cord-021419-nypnib0h	329	15	)	)	-RRB-
cord-021419-nypnib0h	329	16	exhibits	exhibit	VBZ
cord-021419-nypnib0h	329	17	higher	high	JJR
cord-021419-nypnib0h	329	18	activity	activity	NN
cord-021419-nypnib0h	329	19	against	against	IN
cord-021419-nypnib0h	329	20	all	all	DT
cord-021419-nypnib0h	329	21	tested	test	VBN
cord-021419-nypnib0h	329	22	Gram	gram	NN
cord-021419-nypnib0h	329	23	-	-	HYPH
cord-021419-nypnib0h	329	24	positive	positive	JJ
cord-021419-nypnib0h	329	25	bacterial	bacterial	JJ
cord-021419-nypnib0h	329	26	strains	strain	NNS
cord-021419-nypnib0h	329	27	(	(	-LRB-
cord-021419-nypnib0h	329	28	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	329	29	and	and	CC
cord-021419-nypnib0h	329	30	42	42	CD
cord-021419-nypnib0h	329	31	Derivatives	derivative	NNS
cord-021419-nypnib0h	329	32	at	at	IN
cord-021419-nypnib0h	329	33	the	the	DT
cord-021419-nypnib0h	329	34	4	4	CD
cord-021419-nypnib0h	329	35	HH	HH	NNP
cord-021419-nypnib0h	329	36	-cladinose	-cladinose	NN
cord-021419-nypnib0h	329	37	position	position	NN
cord-021419-nypnib0h	330	1	show	show	VB
cord-021419-nypnib0h	330	2	a	a	DT
cord-021419-nypnib0h	330	3	similar	similar	JJ
cord-021419-nypnib0h	330	4	tendency	tendency	NN
cord-021419-nypnib0h	330	5	.	.	.
cord-021419-nypnib0h	331	1	Thus	thus	RB
cord-021419-nypnib0h	331	2	,	,	,
cord-021419-nypnib0h	331	3	they	-PRON-	PRP
cord-021419-nypnib0h	331	4	are	be	VBP
cord-021419-nypnib0h	331	5	inactive	inactive	JJ
cord-021419-nypnib0h	331	6	against	against	IN
cord-021419-nypnib0h	331	7	Gram	gram	NN
cord-021419-nypnib0h	331	8	-	-	HYPH
cord-021419-nypnib0h	331	9	negative	negative	JJ
cord-021419-nypnib0h	331	10	bacteria	bacteria	NNS
cord-021419-nypnib0h	331	11	.	.	.
cord-021419-nypnib0h	332	1	The	the	DT
cord-021419-nypnib0h	332	2	fact	fact	NN
cord-021419-nypnib0h	332	3	that	that	IN
cord-021419-nypnib0h	332	4	the	the	DT
cord-021419-nypnib0h	332	5	hybrid	hybrid	JJ
cord-021419-nypnib0h	332	6	structures	structure	NNS
cord-021419-nypnib0h	332	7	are	be	VBP
cord-021419-nypnib0h	332	8	ineffective	ineffective	JJ
cord-021419-nypnib0h	332	9	against	against	IN
cord-021419-nypnib0h	332	10	E.	E.	NNP
cord-021419-nypnib0h	332	11	coli	coli	NNS
cord-021419-nypnib0h	332	12	25922	25922	CD
cord-021419-nypnib0h	332	13	ATCC	ATCC	NNP
cord-021419-nypnib0h	332	14	and	and	CC
cord-021419-nypnib0h	332	15	other	other	JJ
cord-021419-nypnib0h	332	16	Gram	gram	NN
cord-021419-nypnib0h	332	17	-	-	HYPH
cord-021419-nypnib0h	332	18	negative	negative	JJ
cord-021419-nypnib0h	332	19	bacterial	bacterial	JJ
cord-021419-nypnib0h	332	20	strains	strain	NNS
cord-021419-nypnib0h	332	21	indicates	indicate	VBZ
cord-021419-nypnib0h	332	22	that	that	IN
cord-021419-nypnib0h	332	23	they	-PRON-	PRP
cord-021419-nypnib0h	332	24	can	can	MD
cord-021419-nypnib0h	332	25	not	not	RB
cord-021419-nypnib0h	332	26	penetrate	penetrate	VB
cord-021419-nypnib0h	332	27	the	the	DT
cord-021419-nypnib0h	332	28	outer	outer	JJ
cord-021419-nypnib0h	332	29	phospholipid	phospholipid	NN
cord-021419-nypnib0h	332	30	layer	layer	NN
cord-021419-nypnib0h	332	31	of	of	IN
cord-021419-nypnib0h	332	32	the	the	DT
cord-021419-nypnib0h	332	33	bacterial	bacterial	JJ
cord-021419-nypnib0h	332	34	cell	cell	NN
cord-021419-nypnib0h	332	35	.	.	.
cord-021419-nypnib0h	333	1	In	in	IN
cord-021419-nypnib0h	333	2	all	all	PDT
cord-021419-nypnib0h	333	3	the	the	DT
cord-021419-nypnib0h	333	4	tested	test	VBN
cord-021419-nypnib0h	333	5	Gram	gram	NN
cord-021419-nypnib0h	333	6	-	-	HYPH
cord-021419-nypnib0h	333	7	positive	positive	JJ
cord-021419-nypnib0h	333	8	bacterial	bacterial	JJ
cord-021419-nypnib0h	333	9	strains	strain	NNS
cord-021419-nypnib0h	333	10	,	,	,
cord-021419-nypnib0h	333	11	compounds	compound	VBZ
cord-021419-nypnib0h	333	12	52	52	CD
cord-021419-nypnib0h	333	13	±	±	CD
cord-021419-nypnib0h	333	14	55	55	CD
cord-021419-nypnib0h	333	15	exhibited	exhibit	VBD
cord-021419-nypnib0h	333	16	activity	activity	NN
cord-021419-nypnib0h	333	17	comparable	comparable	JJ
cord-021419-nypnib0h	333	18	to	to	IN
cord-021419-nypnib0h	333	19	or	or	CC
cord-021419-nypnib0h	333	20	higher	high	JJR
cord-021419-nypnib0h	333	21	than	than	IN
cord-021419-nypnib0h	333	22	that	that	DT
cord-021419-nypnib0h	333	23	of	of	IN
cord-021419-nypnib0h	333	24	azithromycin	azithromycin	NN
cord-021419-nypnib0h	333	25	(	(	-LRB-
cord-021419-nypnib0h	333	26	30	30	CD
cord-021419-nypnib0h	333	27	)	)	-RRB-
cord-021419-nypnib0h	333	28	and	and	CC
cord-021419-nypnib0h	333	29	vancomycin	vancomycin	FW
cord-021419-nypnib0h	333	30	(	(	-LRB-
cord-021419-nypnib0h	333	31	1	1	CD
cord-021419-nypnib0h	333	32	)	)	-RRB-
cord-021419-nypnib0h	333	33	.	.	.
cord-021419-nypnib0h	334	1	Their	-PRON-	PRP$
cord-021419-nypnib0h	334	2	activity	activity	NN
cord-021419-nypnib0h	334	3	is	be	VBZ
cord-021419-nypnib0h	334	4	provided	provide	VBN
cord-021419-nypnib0h	334	5	by	by	IN
cord-021419-nypnib0h	334	6	the	the	DT
cord-021419-nypnib0h	334	7	presence	presence	NN
cord-021419-nypnib0h	334	8	of	of	IN
cord-021419-nypnib0h	334	9	the	the	DT
cord-021419-nypnib0h	334	10	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	334	11	moiety	moiety	NN
cord-021419-nypnib0h	334	12	.	.	.
cord-021419-nypnib0h	335	1	Unlike	unlike	IN
cord-021419-nypnib0h	335	2	hybrid	hybrid	JJ
cord-021419-nypnib0h	335	3	vancomycin	vancomycin	NN
cord-021419-nypnib0h	335	4	analogue	analogue	NN
cord-021419-nypnib0h	335	5	58b	58b	NNPS
cord-021419-nypnib0h	335	6	,	,	,
cord-021419-nypnib0h	335	7	hybrid	hybrid	JJ
cord-021419-nypnib0h	335	8	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	335	9	analogue	analogue	NN
cord-021419-nypnib0h	335	10	59b	59b	NNS
cord-021419-nypnib0h	335	11	displays	display	VBZ
cord-021419-nypnib0h	335	12	significant	significant	JJ
cord-021419-nypnib0h	335	13	activity	activity	NN
cord-021419-nypnib0h	335	14	against	against	IN
cord-021419-nypnib0h	335	15	the	the	DT
cord-021419-nypnib0h	335	16	vancomycin	vancomycin	NN
cord-021419-nypnib0h	335	17	-	-	HYPH
cord-021419-nypnib0h	335	18	resistant	resistant	JJ
cord-021419-nypnib0h	335	19	enterococci	enterococci	NNS
cord-021419-nypnib0h	335	20	(	(	-LRB-
cord-021419-nypnib0h	335	21	VRE	VRE	NNP
cord-021419-nypnib0h	335	22	)	)	-RRB-
cord-021419-nypnib0h	336	1	strains	strain	NNS
cord-021419-nypnib0h	336	2	Enterococcus	Enterococcus	NNP
cord-021419-nypnib0h	336	3	faecium	faecium	VB
cord-021419-nypnib0h	336	4	569	569	CD
cord-021419-nypnib0h	337	1	and	and	CC
cord-021419-nypnib0h	337	2	Enterococcus	Enterococcus	NNP
cord-021419-nypnib0h	337	3	faecalis	faecalis	NNP
cord-021419-nypnib0h	337	4	560	560	CD
cord-021419-nypnib0h	337	5	(	(	-LRB-
cord-021419-nypnib0h	337	6	MIC	mic	NN
cord-021419-nypnib0h	337	7	=	=	NFP
cord-021419-nypnib0h	338	1	3.2	3.2	CD
cord-021419-nypnib0h	338	2	and	and	CC
cord-021419-nypnib0h	338	3	6.5	6.5	CD
cord-021419-nypnib0h	338	4	mmol	mmol	NN
cord-021419-nypnib0h	338	5	L	L	NNP
cord-021419-nypnib0h	338	6	71	71	CD
cord-021419-nypnib0h	338	7	)	)	-RRB-
cord-021419-nypnib0h	338	8	,	,	,
cord-021419-nypnib0h	338	9	which	which	WDT
cord-021419-nypnib0h	338	10	can	can	MD
cord-021419-nypnib0h	338	11	be	be	VB
cord-021419-nypnib0h	338	12	attributed	attribute	VBN
cord-021419-nypnib0h	338	13	to	to	IN
cord-021419-nypnib0h	338	14	the	the	DT
cord-021419-nypnib0h	338	15	effect	effect	NN
cord-021419-nypnib0h	338	16	of	of	IN
cord-021419-nypnib0h	338	17	the	the	DT
cord-021419-nypnib0h	338	18	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	338	19	moiety	moiety	NN
cord-021419-nypnib0h	338	20	attached	attach	VBN
cord-021419-nypnib0h	338	21	to	to	IN
cord-021419-nypnib0h	338	22	the	the	DT
cord-021419-nypnib0h	338	23	C	C	NNP
cord-021419-nypnib0h	338	24	-	-	HYPH
cord-021419-nypnib0h	338	25	terminal	terminal	NN
cord-021419-nypnib0h	338	26	group	group	NN
cord-021419-nypnib0h	338	27	of	of	IN
cord-021419-nypnib0h	338	28	the	the	DT
cord-021419-nypnib0h	338	29	peptide	peptide	NN
cord-021419-nypnib0h	338	30	core	core	NN
cord-021419-nypnib0h	338	31	of	of	IN
cord-021419-nypnib0h	338	32	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	338	33	3	3	CD
cord-021419-nypnib0h	338	34	.	.	.
cord-021419-nypnib0h	339	1	42	42	CD
cord-021419-nypnib0h	339	2	,	,	,
cord-021419-nypnib0h	339	3	43	43	CD
cord-021419-nypnib0h	340	1	The	the	DT
cord-021419-nypnib0h	340	2	mechanism	mechanism	NN
cord-021419-nypnib0h	340	3	of	of	IN
cord-021419-nypnib0h	340	4	action	action	NN
cord-021419-nypnib0h	340	5	against	against	IN
cord-021419-nypnib0h	340	6	Gram	gram	NN
cord-021419-nypnib0h	340	7	-	-	HYPH
cord-021419-nypnib0h	340	8	positive	positive	JJ
cord-021419-nypnib0h	340	9	bacteria	bacteria	NNS
cord-021419-nypnib0h	340	10	was	be	VBD
cord-021419-nypnib0h	340	11	confirmed	confirm	VBN
cord-021419-nypnib0h	340	12	by	by	IN
cord-021419-nypnib0h	340	13	quantum	quantum	JJ
cord-021419-nypnib0h	340	14	chemical	chemical	NN
cord-021419-nypnib0h	340	15	calculations	calculation	NNS
cord-021419-nypnib0h	340	16	of	of	IN
cord-021419-nypnib0h	340	17	the	the	DT
cord-021419-nypnib0h	340	18	energy	energy	NN
cord-021419-nypnib0h	340	19	of	of	IN
cord-021419-nypnib0h	340	20	interaction	interaction	NN
cord-021419-nypnib0h	340	21	DG	DG	NNP
cord-021419-nypnib0h	340	22	298	298	CD
cord-021419-nypnib0h	340	23	in	in	IN
cord-021419-nypnib0h	340	24	relation	relation	NN
cord-021419-nypnib0h	340	25	to	to	IN
cord-021419-nypnib0h	340	26	hybrid	hybrid	JJ
cord-021419-nypnib0h	340	27	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	340	28	58b	58b	NNS
cord-021419-nypnib0h	340	29	and	and	CC
cord-021419-nypnib0h	340	30	59b	59b	NNS
cord-021419-nypnib0h	340	31	with	with	IN
cord-021419-nypnib0h	340	32	the	the	DT
cord-021419-nypnib0h	340	33	model	model	NN
cord-021419-nypnib0h	340	34	D	D	NNP
cord-021419-nypnib0h	340	35	-	-	HYPH
cord-021419-nypnib0h	340	36	Ala	ala	NN
cord-021419-nypnib0h	340	37	-	-	HYPH
cord-021419-nypnib0h	340	38	D	D	NNP
cord-021419-nypnib0h	340	39	-	-	HYPH
cord-021419-nypnib0h	340	40	Ala	Ala	NNP
cord-021419-nypnib0h	340	41	ligand	ligand	NN
cord-021419-nypnib0h	340	42	typical	typical	JJ
cord-021419-nypnib0h	340	43	of	of	IN
cord-021419-nypnib0h	340	44	glycopeptides	glycopeptide	NNS
cord-021419-nypnib0h	340	45	.	.	.
cord-021419-nypnib0h	341	1	43	43	CD
cord-021419-nypnib0h	342	1	These	these	DT
cord-021419-nypnib0h	342	2	studies	study	NNS
cord-021419-nypnib0h	342	3	resulted	result	VBD
cord-021419-nypnib0h	342	4	in	in	IN
cord-021419-nypnib0h	342	5	the	the	DT
cord-021419-nypnib0h	342	6	development	development	NN
cord-021419-nypnib0h	342	7	of	of	IN
cord-021419-nypnib0h	342	8	methods	method	NNS
cord-021419-nypnib0h	342	9	for	for	IN
cord-021419-nypnib0h	342	10	the	the	DT
cord-021419-nypnib0h	342	11	synthesis	synthesis	NN
cord-021419-nypnib0h	342	12	of	of	IN
cord-021419-nypnib0h	342	13	macrolide	macrolide	NN
cord-021419-nypnib0h	342	14	-	-	HYPH
cord-021419-nypnib0h	342	15	based	base	VBN
cord-021419-nypnib0h	342	16	hybrid	hybrid	JJ
cord-021419-nypnib0h	342	17	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	342	18	containing	contain	VBG
cord-021419-nypnib0h	342	19	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	342	20	as	as	IN
cord-021419-nypnib0h	342	21	a	a	DT
cord-021419-nypnib0h	342	22	new	new	JJ
cord-021419-nypnib0h	342	23	pharmacophore	pharmacophore	NN
cord-021419-nypnib0h	342	24	.	.	.
cord-021419-nypnib0h	343	1	38	38	CD
cord-021419-nypnib0h	343	2	,	,	,
cord-021419-nypnib0h	343	3	40	40	CD
cord-021419-nypnib0h	343	4	,	,	,
cord-021419-nypnib0h	343	5	41	41	CD
cord-021419-nypnib0h	344	1	The	the	DT
cord-021419-nypnib0h	344	2	behaviour	behaviour	NN
cord-021419-nypnib0h	344	3	of	of	IN
cord-021419-nypnib0h	344	4	the	the	DT
cord-021419-nypnib0h	344	5	macrolide	macrolide	JJ
cord-021419-nypnib0h	344	6	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	344	7	aglycone	aglycone	NN
cord-021419-nypnib0h	344	8	in	in	IN
cord-021419-nypnib0h	344	9	chemical	chemical	JJ
cord-021419-nypnib0h	344	10	reactions	reaction	NNS
cord-021419-nypnib0h	344	11	was	be	VBD
cord-021419-nypnib0h	344	12	found	find	VBN
cord-021419-nypnib0h	344	13	to	to	TO
cord-021419-nypnib0h	344	14	be	be	VB
cord-021419-nypnib0h	344	15	affected	affect	VBN
cord-021419-nypnib0h	344	16	by	by	IN
cord-021419-nypnib0h	344	17	its	-PRON-	PRP$
cord-021419-nypnib0h	344	18	structure	structure	NN
cord-021419-nypnib0h	344	19	,	,	,
cord-021419-nypnib0h	344	20	in	in	IN
cord-021419-nypnib0h	344	21	particular	particular	JJ
cord-021419-nypnib0h	344	22	it	-PRON-	PRP
cord-021419-nypnib0h	344	23	depends	depend	VBZ
cord-021419-nypnib0h	344	24	on	on	IN
cord-021419-nypnib0h	344	25	the	the	DT
cord-021419-nypnib0h	344	26	presence	presence	NN
cord-021419-nypnib0h	344	27	of	of	IN
cord-021419-nypnib0h	344	28	an	an	DT
cord-021419-nypnib0h	344	29	additional	additional	JJ
cord-021419-nypnib0h	344	30	methylamino	methylamino	NN
cord-021419-nypnib0h	344	31	group	group	NN
cord-021419-nypnib0h	344	32	in	in	IN
cord-021419-nypnib0h	344	33	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	344	34	(	(	-LRB-
cord-021419-nypnib0h	344	35	30	30	CD
cord-021419-nypnib0h	344	36	)	)	-RRB-
cord-021419-nypnib0h	344	37	.	.	.
cord-021419-nypnib0h	345	1	38	38	CD
cord-021419-nypnib0h	345	2	,	,	,
cord-021419-nypnib0h	345	3	40	40	CD
cord-021419-nypnib0h	346	1	The	the	DT
cord-021419-nypnib0h	346	2	position	position	NN
cord-021419-nypnib0h	346	3	of	of	IN
cord-021419-nypnib0h	346	4	the	the	DT
cord-021419-nypnib0h	346	5	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	346	6	substituent	substituent	NNP
cord-021419-nypnib0h	346	7	was	be	VBD
cord-021419-nypnib0h	346	8	shown	show	VBN
cord-021419-nypnib0h	346	9	to	to	TO
cord-021419-nypnib0h	346	10	influence	influence	VB
cord-021419-nypnib0h	346	11	the	the	DT
cord-021419-nypnib0h	346	12	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	346	13	activity	activity	NN
cord-021419-nypnib0h	346	14	of	of	IN
cord-021419-nypnib0h	346	15	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	346	16	29	29	CD
cord-021419-nypnib0h	346	17	and	and	CC
cord-021419-nypnib0h	346	18	30	30	CD
cord-021419-nypnib0h	346	19	.	.	.
cord-021419-nypnib0h	347	1	It	-PRON-	PRP
cord-021419-nypnib0h	347	2	was	be	VBD
cord-021419-nypnib0h	347	3	established	establish	VBN
cord-021419-nypnib0h	347	4	that	that	IN
cord-021419-nypnib0h	347	5	the	the	DT
cord-021419-nypnib0h	347	6	C(11)-substituted	c(11)-substituted	CD
cord-021419-nypnib0h	347	7	analogues	analogue	NNS
cord-021419-nypnib0h	347	8	are	be	VBP
cord-021419-nypnib0h	347	9	less	less	RBR
cord-021419-nypnib0h	347	10	effective	effective	JJ
cord-021419-nypnib0h	347	11	inhibitors	inhibitor	NNS
cord-021419-nypnib0h	347	12	of	of	IN
cord-021419-nypnib0h	347	13	Gram	gram	NN
cord-021419-nypnib0h	347	14	-	-	HYPH
cord-021419-nypnib0h	347	15	positive	positive	JJ
cord-021419-nypnib0h	347	16	and	and	CC
cord-021419-nypnib0h	347	17	Gram	gram	NN
cord-021419-nypnib0h	347	18	-	-	HYPH
cord-021419-nypnib0h	347	19	negative	negative	JJ
cord-021419-nypnib0h	347	20	bacteria	bacteria	NNS
cord-021419-nypnib0h	347	21	compared	compare	VBN
cord-021419-nypnib0h	347	22	to	to	IN
cord-021419-nypnib0h	347	23	4	4	CD
cord-021419-nypnib0h	347	24	HH	HH	NNP
cord-021419-nypnib0h	347	25	-substituted	-substituted	NNP
cord-021419-nypnib0h	347	26	analogues	analogue	NNS
cord-021419-nypnib0h	347	27	.	.	.
cord-021419-nypnib0h	348	1	40	40	CD
cord-021419-nypnib0h	348	2	,	,	,
cord-021419-nypnib0h	348	3	41	41	CD
cord-021419-nypnib0h	349	1	The	the	DT
cord-021419-nypnib0h	349	2	presence	presence	NN
cord-021419-nypnib0h	349	3	of	of	IN
cord-021419-nypnib0h	349	4	11,12-cyclic	11,12-cyclic	NNP
cord-021419-nypnib0h	349	5	carbonate	carbonate	NN
cord-021419-nypnib0h	349	6	or	or	CC
cord-021419-nypnib0h	349	7	the	the	DT
cord-021419-nypnib0h	349	8	2	2	CD
cord-021419-nypnib0h	349	9	H	H	NNP
cord-021419-nypnib0h	349	10	-O	-O	:
cord-021419-nypnib0h	349	11	-	-	HYPH
cord-021419-nypnib0h	349	12	acetyl	acetyl	NN
cord-021419-nypnib0h	349	13	group	group	NN
cord-021419-nypnib0h	349	14	in	in	IN
cord-021419-nypnib0h	349	15	the	the	DT
cord-021419-nypnib0h	349	16	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	349	17	molecule	molecule	NN
cord-021419-nypnib0h	349	18	was	be	VBD
cord-021419-nypnib0h	349	19	shown	show	VBN
cord-021419-nypnib0h	349	20	to	to	TO
cord-021419-nypnib0h	349	21	have	have	VB
cord-021419-nypnib0h	349	22	no	no	DT
cord-021419-nypnib0h	349	23	significant	significant	JJ
cord-021419-nypnib0h	349	24	effect	effect	NN
cord-021419-nypnib0h	349	25	on	on	IN
cord-021419-nypnib0h	349	26	the	the	DT
cord-021419-nypnib0h	349	27	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	349	28	activity	activity	NN
cord-021419-nypnib0h	349	29	of	of	IN
cord-021419-nypnib0h	349	30	the	the	DT
cord-021419-nypnib0h	349	31	conjugates	conjugate	NNS
cord-021419-nypnib0h	349	32	,	,	,
cord-021419-nypnib0h	349	33	while	while	IN
cord-021419-nypnib0h	349	34	an	an	DT
cord-021419-nypnib0h	349	35	increase	increase	NN
cord-021419-nypnib0h	349	36	in	in	IN
cord-021419-nypnib0h	349	37	the	the	DT
cord-021419-nypnib0h	349	38	spacer	spacer	NN
cord-021419-nypnib0h	349	39	length	length	NN
cord-021419-nypnib0h	349	40	generally	generally	RB
cord-021419-nypnib0h	349	41	leads	lead	VBZ
cord-021419-nypnib0h	349	42	to	to	IN
cord-021419-nypnib0h	349	43	an	an	DT
cord-021419-nypnib0h	349	44	increase	increase	NN
cord-021419-nypnib0h	349	45	in	in	IN
cord-021419-nypnib0h	349	46	activity	activity	NN
cord-021419-nypnib0h	349	47	of	of	IN
cord-021419-nypnib0h	349	48	the	the	DT
cord-021419-nypnib0h	349	49	final	final	JJ
cord-021419-nypnib0h	349	50	compounds	compound	NNS
cord-021419-nypnib0h	349	51	.	.	.
cord-021419-nypnib0h	350	1	A	a	DT
cord-021419-nypnib0h	350	2	method	method	NN
cord-021419-nypnib0h	350	3	was	be	VBD
cord-021419-nypnib0h	350	4	developed	develop	VBN
cord-021419-nypnib0h	350	5	for	for	IN
cord-021419-nypnib0h	350	6	the	the	DT
cord-021419-nypnib0h	350	7	synthesis	synthesis	NN
cord-021419-nypnib0h	350	8	of	of	IN
cord-021419-nypnib0h	350	9	a	a	DT
cord-021419-nypnib0h	350	10	series	series	NN
cord-021419-nypnib0h	350	11	of	of	IN
cord-021419-nypnib0h	350	12	chimeric	chimeric	JJ
cord-021419-nypnib0h	350	13	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	350	14	based	base	VBN
cord-021419-nypnib0h	350	15	on	on	IN
cord-021419-nypnib0h	350	16	glycopeptides	glycopeptide	NNS
cord-021419-nypnib0h	350	17	and	and	CC
cord-021419-nypnib0h	350	18	azithromycin	azithromycin	NNP
cord-021419-nypnib0h	350	19	(	(	-LRB-
cord-021419-nypnib0h	350	20	30	30	CD
cord-021419-nypnib0h	350	21	)	)	-RRB-
cord-021419-nypnib0h	350	22	.	.	.
cord-021419-nypnib0h	351	1	42	42	CD
cord-021419-nypnib0h	352	1	The	the	DT
cord-021419-nypnib0h	352	2	activity	activity	NN
cord-021419-nypnib0h	352	3	of	of	IN
cord-021419-nypnib0h	352	4	almost	almost	RB
cord-021419-nypnib0h	352	5	all	all	PDT
cord-021419-nypnib0h	352	6	the	the	DT
cord-021419-nypnib0h	352	7	synthesized	synthesize	VBN
cord-021419-nypnib0h	352	8	compounds	compound	NNS
cord-021419-nypnib0h	352	9	against	against	IN
cord-021419-nypnib0h	352	10	the	the	DT
cord-021419-nypnib0h	352	11	tested	test	VBN
cord-021419-nypnib0h	352	12	Gram	gram	NN
cord-021419-nypnib0h	352	13	-	-	HYPH
cord-021419-nypnib0h	352	14	positive	positive	JJ
cord-021419-nypnib0h	352	15	bacterial	bacterial	JJ
cord-021419-nypnib0h	352	16	strains	strain	NNS
cord-021419-nypnib0h	352	17	,	,	,
cord-021419-nypnib0h	352	18	including	include	VBG
cord-021419-nypnib0h	352	19	vancomycin	vancomycin	NN
cord-021419-nypnib0h	352	20	-	-	HYPH
cord-021419-nypnib0h	352	21	resistant	resistant	JJ
cord-021419-nypnib0h	352	22	strains	strain	NNS
cord-021419-nypnib0h	352	23	,	,	,
cord-021419-nypnib0h	352	24	is	be	VBZ
cord-021419-nypnib0h	352	25	similar	similar	JJ
cord-021419-nypnib0h	352	26	to	to	IN
cord-021419-nypnib0h	352	27	or	or	CC
cord-021419-nypnib0h	352	28	higher	high	JJR
cord-021419-nypnib0h	352	29	than	than	IN
cord-021419-nypnib0h	352	30	that	that	DT
cord-021419-nypnib0h	352	31	of	of	IN
cord-021419-nypnib0h	352	32	the	the	DT
cord-021419-nypnib0h	352	33	starting	start	VBG
cord-021419-nypnib0h	352	34	antibiotic	antibiotic	NN
cord-021419-nypnib0h	352	35	.	.	.
cord-021419-nypnib0h	353	1	The	the	DT
cord-021419-nypnib0h	353	2	range	range	NN
cord-021419-nypnib0h	353	3	of	of	IN
cord-021419-nypnib0h	353	4	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	353	5	activity	activity	NN
cord-021419-nypnib0h	353	6	of	of	IN
cord-021419-nypnib0h	353	7	the	the	DT
cord-021419-nypnib0h	353	8	resulting	result	VBG
cord-021419-nypnib0h	353	9	hybrid	hybrid	JJ
cord-021419-nypnib0h	353	10	derivatives	derivative	NNS
cord-021419-nypnib0h	353	11	and	and	CC
cord-021419-nypnib0h	353	12	quantum	quantum	JJ
cord-021419-nypnib0h	353	13	chemical	chemical	NN
cord-021419-nypnib0h	353	14	calculations	calculation	NNS
cord-021419-nypnib0h	353	15	suggest	suggest	VBP
cord-021419-nypnib0h	353	16	that	that	IN
cord-021419-nypnib0h	353	17	the	the	DT
cord-021419-nypnib0h	353	18	antibacterial	antibacterial	JJ
cord-021419-nypnib0h	353	19	activity	activity	NN
cord-021419-nypnib0h	353	20	is	be	VBZ
cord-021419-nypnib0h	353	21	determined	determine	VBN
cord-021419-nypnib0h	353	22	by	by	IN
cord-021419-nypnib0h	353	23	the	the	DT
cord-021419-nypnib0h	353	24	presence	presence	NN
cord-021419-nypnib0h	353	25	of	of	IN
cord-021419-nypnib0h	353	26	the	the	DT
cord-021419-nypnib0h	353	27	glycopep-	glycopep-	NN
cord-021419-nypnib0h	353	28	 	 	_SP
cord-021419-nypnib0h	353	29	Carbohydrate	Carbohydrate	NNP
cord-021419-nypnib0h	353	30	-	-	HYPH
cord-021419-nypnib0h	353	31	containing	contain	VBG
cord-021419-nypnib0h	353	32	polyene	polyene	NNP
cord-021419-nypnib0h	353	33	macrolides	macrolide	NNS
cord-021419-nypnib0h	353	34	are	be	VBP
cord-021419-nypnib0h	353	35	commonly	commonly	RB
cord-021419-nypnib0h	353	36	used	use	VBN
cord-021419-nypnib0h	353	37	in	in	IN
cord-021419-nypnib0h	353	38	medicine	medicine	NN
cord-021419-nypnib0h	353	39	for	for	IN
cord-021419-nypnib0h	353	40	the	the	DT
cord-021419-nypnib0h	353	41	treatment	treatment	NN
cord-021419-nypnib0h	353	42	of	of	IN
cord-021419-nypnib0h	353	43	both	both	CC
cord-021419-nypnib0h	353	44	superficial	superficial	JJ
cord-021419-nypnib0h	353	45	and	and	CC
cord-021419-nypnib0h	353	46	systemic	systemic	JJ
cord-021419-nypnib0h	353	47	mycoses	mycose	NNS
cord-021419-nypnib0h	353	48	due	due	IN
cord-021419-nypnib0h	353	49	to	to	IN
cord-021419-nypnib0h	353	50	their	-PRON-	PRP$
cord-021419-nypnib0h	353	51	high	high	JJ
cord-021419-nypnib0h	353	52	activity	activity	NN
cord-021419-nypnib0h	353	53	and	and	CC
cord-021419-nypnib0h	353	54	a	a	DT
cord-021419-nypnib0h	353	55	broad	broad	JJ
cord-021419-nypnib0h	353	56	spectrum	spectrum	NN
cord-021419-nypnib0h	353	57	of	of	IN
cord-021419-nypnib0h	353	58	action	action	NN
cord-021419-nypnib0h	353	59	.	.	.
cord-021419-nypnib0h	354	1	44	44	CD
cord-021419-nypnib0h	354	2	,	,	,
cord-021419-nypnib0h	354	3	45	45	CD
cord-021419-nypnib0h	355	1	The	the	DT
cord-021419-nypnib0h	355	2	mechanism	mechanism	NN
cord-021419-nypnib0h	355	3	of	of	IN
cord-021419-nypnib0h	355	4	action	action	NN
cord-021419-nypnib0h	355	5	of	of	IN
cord-021419-nypnib0h	355	6	polyene	polyene	NNP
cord-021419-nypnib0h	355	7	macrolides	macrolide	NNS
cord-021419-nypnib0h	355	8	is	be	VBZ
cord-021419-nypnib0h	355	9	related	relate	VBN
cord-021419-nypnib0h	355	10	to	to	IN
cord-021419-nypnib0h	355	11	their	-PRON-	PRP$
cord-021419-nypnib0h	355	12	ability	ability	NN
cord-021419-nypnib0h	355	13	to	to	TO
cord-021419-nypnib0h	355	14	interact	interact	VB
cord-021419-nypnib0h	355	15	with	with	IN
cord-021419-nypnib0h	355	16	sterol	sterol	NN
cord-021419-nypnib0h	355	17	-	-	HYPH
cord-021419-nypnib0h	355	18	containing	contain	VBG
cord-021419-nypnib0h	355	19	cytoplasmic	cytoplasmic	JJ
cord-021419-nypnib0h	355	20	membranes	membrane	NNS
cord-021419-nypnib0h	355	21	and	and	CC
cord-021419-nypnib0h	355	22	form	form	NN
cord-021419-nypnib0h	355	23	pores	pore	NNS
cord-021419-nypnib0h	355	24	(	(	-LRB-
cord-021419-nypnib0h	355	25	channels	channel	NNS
cord-021419-nypnib0h	355	26	)	)	-RRB-
cord-021419-nypnib0h	355	27	in	in	IN
cord-021419-nypnib0h	355	28	these	these	DT
cord-021419-nypnib0h	355	29	membaranes	membarane	NNS
cord-021419-nypnib0h	355	30	,	,	,
cord-021419-nypnib0h	355	31	by	by	IN
cord-021419-nypnib0h	355	32	which	which	WDT
cord-021419-nypnib0h	355	33	ions	ion	NNS
cord-021419-nypnib0h	355	34	leave	leave	VBP
cord-021419-nypnib0h	355	35	the	the	DT
cord-021419-nypnib0h	355	36	cell	cell	NN
cord-021419-nypnib0h	355	37	causing	cause	VBG
cord-021419-nypnib0h	355	38	its	-PRON-	PRP$
cord-021419-nypnib0h	355	39	death	death	NN
cord-021419-nypnib0h	355	40	.	.	.
cord-021419-nypnib0h	356	1	The	the	DT
cord-021419-nypnib0h	356	2	efficacy	efficacy	NN
cord-021419-nypnib0h	356	3	of	of	IN
cord-021419-nypnib0h	356	4	polyenes	polyene	NNS
cord-021419-nypnib0h	356	5	against	against	IN
cord-021419-nypnib0h	356	6	fungal	fungal	JJ
cord-021419-nypnib0h	356	7	pathogens	pathogen	NNS
cord-021419-nypnib0h	356	8	is	be	VBZ
cord-021419-nypnib0h	356	9	due	due	JJ
cord-021419-nypnib0h	356	10	to	to	IN
cord-021419-nypnib0h	356	11	their	-PRON-	PRP$
cord-021419-nypnib0h	356	12	stronger	strong	JJR
cord-021419-nypnib0h	356	13	binding	binding	NN
cord-021419-nypnib0h	356	14	to	to	IN
cord-021419-nypnib0h	356	15	fungal	fungal	JJ
cord-021419-nypnib0h	356	16	membrane	membrane	NN
cord-021419-nypnib0h	356	17	ergosterols	ergosterol	NNS
cord-021419-nypnib0h	356	18	compared	compare	VBN
cord-021419-nypnib0h	356	19	to	to	IN
cord-021419-nypnib0h	356	20	cholesterol	cholesterol	NN
cord-021419-nypnib0h	356	21	present	present	JJ
cord-021419-nypnib0h	356	22	in	in	IN
cord-021419-nypnib0h	356	23	human	human	JJ
cord-021419-nypnib0h	356	24	and	and	CC
cord-021419-nypnib0h	356	25	animal	animal	NN
cord-021419-nypnib0h	356	26	cell	cell	NN
cord-021419-nypnib0h	356	27	membranes	membrane	NNS
cord-021419-nypnib0h	356	28	.	.	.
cord-021419-nypnib0h	357	1	Nystatin	Nystatin	NNP
cord-021419-nypnib0h	357	2	(	(	-LRB-
cord-021419-nypnib0h	357	3	62a	62a	NNS
cord-021419-nypnib0h	357	4	)	)	-RRB-
cord-021419-nypnib0h	357	5	,	,	,
cord-021419-nypnib0h	357	6	partricin	partricin	NNS
cord-021419-nypnib0h	357	7	and	and	CC
cord-021419-nypnib0h	357	8	pimaricin	pimaricin	NNS
cord-021419-nypnib0h	357	9	are	be	VBP
cord-021419-nypnib0h	357	10	administered	administer	VBN
cord-021419-nypnib0h	357	11	locally	locally	RB
cord-021419-nypnib0h	357	12	,	,	,
cord-021419-nypnib0h	357	13	whereas	whereas	IN
cord-021419-nypnib0h	357	14	amphotericin	amphotericin	NNS
cord-021419-nypnib0h	357	15	B	b	NN
cord-021419-nypnib0h	357	16	(	(	-LRB-
cord-021419-nypnib0h	357	17	AmB	amb	NN
cord-021419-nypnib0h	357	18	,	,	,
cord-021419-nypnib0h	357	19	63a	63a	NNP
cord-021419-nypnib0h	357	20	)	)	-RRB-
cord-021419-nypnib0h	357	21	is	be	VBZ
cord-021419-nypnib0h	357	22	the	the	DT
cord-021419-nypnib0h	357	23	only	only	JJ
cord-021419-nypnib0h	357	24	polyene	polyene	NN
cord-021419-nypnib0h	357	25	that	that	WDT
cord-021419-nypnib0h	357	26	is	be	VBZ
cord-021419-nypnib0h	357	27	applied	apply	VBN
cord-021419-nypnib0h	357	28	for	for	IN
cord-021419-nypnib0h	357	29	the	the	DT
cord-021419-nypnib0h	357	30	treatment	treatment	NN
cord-021419-nypnib0h	357	31	of	of	IN
cord-021419-nypnib0h	357	32	systemic	systemic	JJ
cord-021419-nypnib0h	357	33	mycoses	mycose	NNS
cord-021419-nypnib0h	357	34	.	.	.
cord-021419-nypnib0h	358	1	Unfortunately	unfortunately	RB
cord-021419-nypnib0h	358	2	,	,	,
cord-021419-nypnib0h	358	3	polyenes	polyene	NNS
cord-021419-nypnib0h	358	4	are	be	VBP
cord-021419-nypnib0h	358	5	rather	rather	RB
cord-021419-nypnib0h	358	6	toxic	toxic	JJ
cord-021419-nypnib0h	358	7	agents	agent	NNS
cord-021419-nypnib0h	358	8	because	because	IN
cord-021419-nypnib0h	358	9	of	of	IN
cord-021419-nypnib0h	358	10	their	-PRON-	PRP$
cord-021419-nypnib0h	358	11	low	low	JJ
cord-021419-nypnib0h	358	12	selectivity	selectivity	NN
cord-021419-nypnib0h	358	13	for	for	IN
cord-021419-nypnib0h	358	14	fungal	fungal	NN
cord-021419-nypnib0h	358	15	versus	versus	IN
cord-021419-nypnib0h	358	16	mammalian	mammalian	JJ
cord-021419-nypnib0h	358	17	cell	cell	NN
cord-021419-nypnib0h	358	18	.	.	.
cord-021419-nypnib0h	359	1	Poor	poor	JJ
cord-021419-nypnib0h	359	2	solubility	solubility	NN
cord-021419-nypnib0h	359	3	of	of	IN
cord-021419-nypnib0h	359	4	polyenes	polyene	NNS
cord-021419-nypnib0h	359	5	in	in	IN
cord-021419-nypnib0h	359	6	water	water	NN
cord-021419-nypnib0h	359	7	,	,	,
cord-021419-nypnib0h	359	8	their	-PRON-	PRP$
cord-021419-nypnib0h	359	9	high	high	JJ
cord-021419-nypnib0h	359	10	hematotoxicity	hematotoxicity	NN
cord-021419-nypnib0h	359	11	and	and	CC
cord-021419-nypnib0h	359	12	nephrotoxicity	nephrotoxicity	NN
cord-021419-nypnib0h	359	13	and	and	CC
cord-021419-nypnib0h	359	14	a	a	DT
cord-021419-nypnib0h	359	15	number	number	NN
cord-021419-nypnib0h	359	16	of	of	IN
cord-021419-nypnib0h	359	17	other	other	JJ
cord-021419-nypnib0h	359	18	adverse	adverse	JJ
cord-021419-nypnib0h	359	19	effects	effect	NNS
cord-021419-nypnib0h	359	20	have	have	VBP
cord-021419-nypnib0h	359	21	stimulated	stimulate	VBN
cord-021419-nypnib0h	359	22	an	an	DT
cord-021419-nypnib0h	359	23	extensive	extensive	JJ
cord-021419-nypnib0h	359	24	search	search	NN
cord-021419-nypnib0h	359	25	for	for	IN
cord-021419-nypnib0h	359	26	new	new	JJ
cord-021419-nypnib0h	359	27	,	,	,
cord-021419-nypnib0h	359	28	less	less	RBR
cord-021419-nypnib0h	359	29	toxic	toxic	JJ
cord-021419-nypnib0h	359	30	and	and	CC
cord-021419-nypnib0h	359	31	more	more	JJR
cord-021419-nypnib0h	359	32	effective	effective	JJ
cord-021419-nypnib0h	359	33	agents	agent	NNS
cord-021419-nypnib0h	359	34	.	.	.
cord-021419-nypnib0h	360	1	Previously	previously	RB
cord-021419-nypnib0h	360	2	,	,	,
cord-021419-nypnib0h	360	3	it	-PRON-	PRP
cord-021419-nypnib0h	360	4	was	be	VBD
cord-021419-nypnib0h	360	5	shown	show	VBN
cord-021419-nypnib0h	360	6	that	that	IN
cord-021419-nypnib0h	360	7	toxicity	toxicity	NN
cord-021419-nypnib0h	360	8	of	of	IN
cord-021419-nypnib0h	360	9	compound	compound	NN
cord-021419-nypnib0h	360	10	63a	63a	NNS
cord-021419-nypnib0h	360	11	and	and	CC
cord-021419-nypnib0h	360	12	other	other	JJ
cord-021419-nypnib0h	360	13	polyenes	polyene	NNS
cord-021419-nypnib0h	360	14	can	can	MD
cord-021419-nypnib0h	360	15	be	be	VB
cord-021419-nypnib0h	360	16	reduced	reduce	VBN
cord-021419-nypnib0h	360	17	by	by	IN
cord-021419-nypnib0h	360	18	chemical	chemical	JJ
cord-021419-nypnib0h	360	19	modification	modification	NN
cord-021419-nypnib0h	360	20	,	,	,
cord-021419-nypnib0h	360	21	which	which	WDT
cord-021419-nypnib0h	360	22	leads	lead	VBZ
cord-021419-nypnib0h	360	23	to	to	IN
cord-021419-nypnib0h	360	24	a	a	DT
cord-021419-nypnib0h	360	25	decrease	decrease	NN
cord-021419-nypnib0h	360	26	in	in	IN
cord-021419-nypnib0h	360	27	side	side	NN
cord-021419-nypnib0h	360	28	effects	effect	NNS
cord-021419-nypnib0h	360	29	.	.	.
cord-021419-nypnib0h	361	1	44	44	CD
cord-021419-nypnib0h	361	2	,	,	,
cord-021419-nypnib0h	361	3	45	45	CD
cord-021419-nypnib0h	361	4	The	the	DT
cord-021419-nypnib0h	361	5	toxic	toxic	JJ
cord-021419-nypnib0h	361	6	effect	effect	NN
cord-021419-nypnib0h	361	7	of	of	IN
cord-021419-nypnib0h	361	8	compound	compound	NN
cord-021419-nypnib0h	361	9	63a	63a	NNS
cord-021419-nypnib0h	361	10	on	on	IN
cord-021419-nypnib0h	361	11	blood	blood	NN
cord-021419-nypnib0h	361	12	cells	cell	NNS
cord-021419-nypnib0h	361	13	(	(	-LRB-
cord-021419-nypnib0h	361	14	haemolysis	haemolysis	NN
cord-021419-nypnib0h	361	15	)	)	-RRB-
cord-021419-nypnib0h	361	16	is	be	VBZ
cord-021419-nypnib0h	361	17	particularly	particularly	RB
cord-021419-nypnib0h	361	18	dangerous	dangerous	JJ
cord-021419-nypnib0h	361	19	.	.	.
cord-021419-nypnib0h	362	1	In	in	IN
cord-021419-nypnib0h	362	2	order	order	NN
cord-021419-nypnib0h	362	3	to	to	TO
cord-021419-nypnib0h	362	4	improve	improve	VB
cord-021419-nypnib0h	362	5	antifungal	antifungal	JJ
cord-021419-nypnib0h	362	6	properties	property	NNS
cord-021419-nypnib0h	362	7	,	,	,
cord-021419-nypnib0h	362	8	cytotoxic	cytotoxic	JJ
cord-021419-nypnib0h	362	9	and	and	CC
cord-021419-nypnib0h	362	10	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	362	11	characteristics	characteristic	NNS
cord-021419-nypnib0h	362	12	and	and	CC
cord-021419-nypnib0h	362	13	to	to	TO
cord-021419-nypnib0h	362	14	study	study	VB
cord-021419-nypnib0h	362	15	the	the	DT
cord-021419-nypnib0h	362	16	mechanisms	mechanism	NNS
cord-021419-nypnib0h	362	17	of	of	IN
cord-021419-nypnib0h	362	18	action	action	NN
cord-021419-nypnib0h	362	19	,	,	,
cord-021419-nypnib0h	362	20	series	series	NN
cord-021419-nypnib0h	362	21	of	of	IN
cord-021419-nypnib0h	362	22	new	new	JJ
cord-021419-nypnib0h	362	23	semi	semi	JJ
cord-021419-nypnib0h	362	24	-	-	JJ
cord-021419-nypnib0h	362	25	synthetic	synthetic	JJ
cord-021419-nypnib0h	362	26	derivatives	derivative	NNS
cord-021419-nypnib0h	362	27	based	base	VBN
cord-021419-nypnib0h	362	28	on	on	IN
cord-021419-nypnib0h	362	29	AmB	amb	NN
cord-021419-nypnib0h	362	30	(	(	-LRB-
cord-021419-nypnib0h	362	31	63a	63a	NNP
cord-021419-nypnib0h	362	32	)	)	-RRB-
cord-021419-nypnib0h	362	33	and	and	CC
cord-021419-nypnib0h	362	34	bioengineered	bioengineere	VBN
cord-021419-nypnib0h	362	35	analogues	analogue	NNS
cord-021419-nypnib0h	363	1	S44HP	s44hp	CC
cord-021419-nypnib0h	363	2	(	(	-LRB-
cord-021419-nypnib0h	363	3	64a	64a	NN
cord-021419-nypnib0h	363	4	)	)	-RRB-
cord-021419-nypnib0h	363	5	,	,	,
cord-021419-nypnib0h	363	6	BSG005	BSG005	NNP
cord-021419-nypnib0h	363	7	(	(	-LRB-
cord-021419-nypnib0h	363	8	65a	65a	CD
cord-021419-nypnib0h	363	9	)	)	-RRB-
cord-021419-nypnib0h	363	10	,	,	.
cord-021419-nypnib0h	364	1	BSG022	BSG022	NNP
cord-021419-nypnib0h	364	2	(	(	-LRB-
cord-021419-nypnib0h	364	3	66a	66a	NN
cord-021419-nypnib0h	364	4	)	)	-RRB-
cord-021419-nypnib0h	364	5	,	,	.
cord-021419-nypnib0h	365	1	BSG019	BSG019	NNP
cord-021419-nypnib0h	365	2	(	(	-LRB-
cord-021419-nypnib0h	365	3	67	67	CD
cord-021419-nypnib0h	365	4	)	)	-RRB-
cord-021419-nypnib0h	365	5	,	,	,
cord-021419-nypnib0h	365	6	BSG003	BSG003	NNP
cord-021419-nypnib0h	365	7	(	(	-LRB-
cord-021419-nypnib0h	365	8	68a	68a	CD
cord-021419-nypnib0h	365	9	)	)	-RRB-
cord-021419-nypnib0h	365	10	and	and	CC
cord-021419-nypnib0h	365	11	BSG018	BSG018	NNP
cord-021419-nypnib0h	365	12	(	(	-LRB-
cord-021419-nypnib0h	365	13	69	69	CD
cord-021419-nypnib0h	365	14	)	)	-RRB-
cord-021419-nypnib0h	365	15	were	be	VBD
cord-021419-nypnib0h	365	16	synthesized	synthesize	VBN
cord-021419-nypnib0h	365	17	(	(	-LRB-
cord-021419-nypnib0h	365	18	in	in	IN
cord-021419-nypnib0h	365	19	collaboration	collaboration	NN
cord-021419-nypnib0h	365	20	with	with	IN
cord-021419-nypnib0h	365	21	the	the	DT
cord-021419-nypnib0h	365	22	company	company	NN
cord-021419-nypnib0h	365	23	BIOSERGEN	BIOSERGEN	NNP
cord-021419-nypnib0h	365	24	,	,	,
cord-021419-nypnib0h	365	25	Norway	Norway	NNP
cord-021419-nypnib0h	365	26	)	)	-RRB-
cord-021419-nypnib0h	366	1	(	(	-LRB-
cord-021419-nypnib0h	366	2	Scheme	scheme	NN
cord-021419-nypnib0h	366	3	17	17	CD
cord-021419-nypnib0h	366	4	)	)	-RRB-
cord-021419-nypnib0h	366	5	.	.	.
cord-021419-nypnib0h	367	1	46	46	CD
cord-021419-nypnib0h	367	2	±	±	CD
cord-021419-nypnib0h	367	3	49	49	CD
cord-021419-nypnib0h	368	1	The	the	DT
cord-021419-nypnib0h	368	2	structural	structural	JJ
cord-021419-nypnib0h	368	3	diversity	diversity	NN
cord-021419-nypnib0h	368	4	of	of	IN
cord-021419-nypnib0h	368	5	the	the	DT
cord-021419-nypnib0h	368	6	above	above	RB
cord-021419-nypnib0h	368	7	-	-	HYPH
cord-021419-nypnib0h	368	8	mentioned	mention	VBN
cord-021419-nypnib0h	368	9	polyenes	polyene	NNS
cord-021419-nypnib0h	368	10	64a	64a	NNP
cord-021419-nypnib0h	368	11	±	±	CD
cord-021419-nypnib0h	368	12	66a	66a	NN
cord-021419-nypnib0h	368	13	,	,	,
cord-021419-nypnib0h	368	14	67	67	CD
cord-021419-nypnib0h	368	15	,	,	,
cord-021419-nypnib0h	368	16	68a	68a	NNS
cord-021419-nypnib0h	368	17	and	and	CC
cord-021419-nypnib0h	368	18	69	69	CD
cord-021419-nypnib0h	368	19	was	be	VBD
cord-021419-nypnib0h	368	20	provided	provide	VBN
cord-021419-nypnib0h	368	21	by	by	IN
cord-021419-nypnib0h	368	22	using	use	VBG
cord-021419-nypnib0h	368	23	methods	method	NNS
cord-021419-nypnib0h	368	24	of	of	IN
cord-021419-nypnib0h	368	25	genetic	genetic	JJ
cord-021419-nypnib0h	368	26	engineering	engineering	NN
cord-021419-nypnib0h	368	27	to	to	TO
cord-021419-nypnib0h	368	28	alter	alter	VB
cord-021419-nypnib0h	368	29	genes	gene	NNS
cord-021419-nypnib0h	368	30	encoding	encode	VBG
cord-021419-nypnib0h	368	31	the	the	DT
cord-021419-nypnib0h	368	32	nystatin	nystatin	NN
cord-021419-nypnib0h	368	33	-	-	HYPH
cord-021419-nypnib0h	368	34	producing	produce	VBG
cord-021419-nypnib0h	368	35	strain	strain	NN
cord-021419-nypnib0h	368	36	Streptomyces	Streptomyces	NNP
cord-021419-nypnib0h	368	37	noursei	noursei	NN
cord-021419-nypnib0h	368	38	.	.	.
cord-021419-nypnib0h	369	1	50	50	CD
cord-021419-nypnib0h	369	2	New	new	JJ
cord-021419-nypnib0h	369	3	analogues	analogue	NNS
cord-021419-nypnib0h	369	4	compare	compare	VBP
cord-021419-nypnib0h	369	5	favourably	favourably	RB
cord-021419-nypnib0h	369	6	with	with	IN
cord-021419-nypnib0h	369	7	nystatin	nystatin	NNS
cord-021419-nypnib0h	369	8	(	(	-LRB-
cord-021419-nypnib0h	369	9	62a	62a	NNS
cord-021419-nypnib0h	369	10	)	)	-RRB-
cord-021419-nypnib0h	369	11	,	,	,
cord-021419-nypnib0h	369	12	primarily	primarily	RB
cord-021419-nypnib0h	369	13	due	due	IN
cord-021419-nypnib0h	369	14	to	to	IN
cord-021419-nypnib0h	369	15	the	the	DT
cord-021419-nypnib0h	369	16	presence	presence	NN
cord-021419-nypnib0h	369	17	of	of	IN
cord-021419-nypnib0h	369	18	a	a	DT
cord-021419-nypnib0h	369	19	double	double	JJ
cord-021419-nypnib0h	369	20	bond	bond	NN
cord-021419-nypnib0h	369	21	(	(	-LRB-
cord-021419-nypnib0h	369	22	instead	instead	RB
cord-021419-nypnib0h	369	23	of	of	IN
cord-021419-nypnib0h	369	24	a	a	DT
cord-021419-nypnib0h	369	25	single	single	JJ
cord-021419-nypnib0h	369	26	one	one	CD
cord-021419-nypnib0h	369	27	)	)	-RRB-
cord-021419-nypnib0h	369	28	at	at	IN
cord-021419-nypnib0h	369	29	C(28	C(28	NNP
cord-021419-nypnib0h	369	30	)	)	-RRB-
cord-021419-nypnib0h	369	31	±	±	NNP
cord-021419-nypnib0h	369	32	C(29	C(29	NNP
cord-021419-nypnib0h	369	33	)	)	-RRB-
cord-021419-nypnib0h	369	34	characteristic	characteristic	NN
cord-021419-nypnib0h	369	35	of	of	IN
cord-021419-nypnib0h	369	36	63a	63a	NNS
cord-021419-nypnib0h	369	37	and	and	CC
cord-021419-nypnib0h	369	38	other	other	JJ
cord-021419-nypnib0h	369	39	polyenes	polyene	NNS
cord-021419-nypnib0h	369	40	64	64	CD
cord-021419-nypnib0h	369	41	±	±	NNP
cord-021419-nypnib0h	369	42	69	69	CD
cord-021419-nypnib0h	369	43	.	.	.
cord-021419-nypnib0h	370	1	The	the	DT
cord-021419-nypnib0h	370	2	heptaene	heptaene	NNP
cord-021419-nypnib0h	370	3	group	group	NN
cord-021419-nypnib0h	370	4	of	of	IN
cord-021419-nypnib0h	370	5	the	the	DT
cord-021419-nypnib0h	370	6	aglycone	aglycone	NN
cord-021419-nypnib0h	370	7	imparts	impart	VBZ
cord-021419-nypnib0h	370	8	rigidity	rigidity	NN
cord-021419-nypnib0h	370	9	to	to	IN
cord-021419-nypnib0h	370	10	the	the	DT
cord-021419-nypnib0h	370	11	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	370	12	structure	structure	NN
cord-021419-nypnib0h	370	13	and	and	CC
cord-021419-nypnib0h	370	14	improves	improve	VBZ
cord-021419-nypnib0h	370	15	antifungal	antifungal	JJ
cord-021419-nypnib0h	370	16	activity	activity	NN
cord-021419-nypnib0h	370	17	.	.	.
cord-021419-nypnib0h	371	1	New	new	JJ
cord-021419-nypnib0h	371	2	monosubstituted	monosubstituted	JJ
cord-021419-nypnib0h	371	3	polyene	polyene	NNP
cord-021419-nypnib0h	371	4	macrolides	macrolide	NNS
cord-021419-nypnib0h	371	5	at	at	IN
cord-021419-nypnib0h	371	6	the	the	DT
cord-021419-nypnib0h	371	7	terminal	terminal	NN
cord-021419-nypnib0h	372	1	16-CO	16-co	LS
cord-021419-nypnib0h	372	2	2	2	CD
cord-021419-nypnib0h	372	3	H	h	NN
cord-021419-nypnib0h	372	4	group	group	NN
cord-021419-nypnib0h	372	5	of	of	IN
cord-021419-nypnib0h	372	6	the	the	DT
cord-021419-nypnib0h	372	7	aglycone	aglycone	NNP
cord-021419-nypnib0h	372	8	were	be	VBD
cord-021419-nypnib0h	372	9	synthesized	synthesize	VBN
cord-021419-nypnib0h	372	10	based	base	VBN
cord-021419-nypnib0h	372	11	on	on	IN
cord-021419-nypnib0h	372	12	compounds	compound	NNS
cord-021419-nypnib0h	372	13	63a	63a	NNS
cord-021419-nypnib0h	372	14	and	and	CC
cord-021419-nypnib0h	372	15	64a	64a	NNS
cord-021419-nypnib0h	372	16	;	;	,
cord-021419-nypnib0h	372	17	monosubstituted	monosubstituted	JJ
cord-021419-nypnib0h	372	18	polyene	polyene	NNP
cord-021419-nypnib0h	372	19	macrolides	macrolide	NNS
cord-021419-nypnib0h	372	20	at	at	IN
cord-021419-nypnib0h	372	21	the	the	DT
cord-021419-nypnib0h	372	22	mycosamine	mycosamine	JJ
cord-021419-nypnib0h	372	23	3	3	CD
cord-021419-nypnib0h	372	24	H	H	NNP
cord-021419-nypnib0h	372	25	-amino	-amino	HYPH
cord-021419-nypnib0h	372	26	group	group	NN
cord-021419-nypnib0h	372	27	were	be	VBD
cord-021419-nypnib0h	372	28	prepared	prepare	VBN
cord-021419-nypnib0h	372	29	based	base	VBN
cord-021419-nypnib0h	372	30	on	on	IN
cord-021419-nypnib0h	372	31	63a	63a	NNS
cord-021419-nypnib0h	372	32	,	,	,
cord-021419-nypnib0h	372	33	64a	64a	NNS
cord-021419-nypnib0h	372	34	and	and	CC
cord-021419-nypnib0h	372	35	65a	65a	NNS
cord-021419-nypnib0h	372	36	.	.	.
cord-021419-nypnib0h	373	1	47	47	CD
cord-021419-nypnib0h	373	2	,	,	,
cord-021419-nypnib0h	373	3	48	48	CD
cord-021419-nypnib0h	374	1	The	the	DT
cord-021419-nypnib0h	374	2	synthesis	synthesis	NN
cord-021419-nypnib0h	374	3	of	of	IN
cord-021419-nypnib0h	374	4	doubly	doubly	RB
cord-021419-nypnib0h	374	5	modified	modify	VBN
cord-021419-nypnib0h	374	6	analogues	analogue	NNS
cord-021419-nypnib0h	374	7	of	of	IN
cord-021419-nypnib0h	374	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	374	9	63a	63a	NNS
cord-021419-nypnib0h	374	10	and	and	CC
cord-021419-nypnib0h	374	11	64a	64a	NNS
cord-021419-nypnib0h	374	12	was	be	VBD
cord-021419-nypnib0h	374	13	reported	report	VBN
cord-021419-nypnib0h	374	14	.	.	.
cord-021419-nypnib0h	375	1	48	48	CD
cord-021419-nypnib0h	376	1	The	the	DT
cord-021419-nypnib0h	376	2	related	related	JJ
cord-021419-nypnib0h	376	3	amido	amido	NN
cord-021419-nypnib0h	376	4	derivatives	derivative	NNS
cord-021419-nypnib0h	376	5	(	(	-LRB-
cord-021419-nypnib0h	376	6	64b	64b	NN
cord-021419-nypnib0h	376	7	±	±	NNP
cord-021419-nypnib0h	376	8	64h	64h	NNS
cord-021419-nypnib0h	376	9	)	)	-RRB-
cord-021419-nypnib0h	377	1	substituted	substitute	VBN
cord-021419-nypnib0h	377	2	in	in	IN
cord-021419-nypnib0h	377	3	a	a	DT
cord-021419-nypnib0h	377	4	similar	similar	JJ
cord-021419-nypnib0h	377	5	way	way	NN
cord-021419-nypnib0h	377	6	at	at	IN
cord-021419-nypnib0h	377	7	the	the	DT
cord-021419-nypnib0h	377	8	C(16)-carboxamide	C(16)-carboxamide	NNP
cord-021419-nypnib0h	377	9	group	group	NN
cord-021419-nypnib0h	377	10	of	of	IN
cord-021419-nypnib0h	377	11	S44HP	S44HP	NNS
cord-021419-nypnib0h	377	12	were	be	VBD
cord-021419-nypnib0h	377	13	prepared	prepare	VBN
cord-021419-nypnib0h	377	14	.	.	.
cord-021419-nypnib0h	378	1	46	46	CD
cord-021419-nypnib0h	378	2	±	±	CD
cord-021419-nypnib0h	378	3	49	49	CD
cord-021419-nypnib0h	379	1	The	the	DT
cord-021419-nypnib0h	379	2	yields	yield	NNS
cord-021419-nypnib0h	379	3	of	of	IN
cord-021419-nypnib0h	379	4	C(16)-amido	C(16)-amido	NNP
cord-021419-nypnib0h	379	5	derivatives	derivative	NNS
cord-021419-nypnib0h	379	6	were	be	VBD
cord-021419-nypnib0h	379	7	*	*	NFP
cord-021419-nypnib0h	379	8	50	50	CD
cord-021419-nypnib0h	379	9	%	%	NN
cord-021419-nypnib0h	379	10	±	±	NNP
cord-021419-nypnib0h	379	11	90	90	CD
cord-021419-nypnib0h	379	12	%	%	NN
cord-021419-nypnib0h	379	13	depending	depend	VBG
cord-021419-nypnib0h	379	14	on	on	IN
cord-021419-nypnib0h	379	15	the	the	DT
cord-021419-nypnib0h	379	16	structure	structure	NN
cord-021419-nypnib0h	379	17	of	of	IN
cord-021419-nypnib0h	379	18	the	the	DT
cord-021419-nypnib0h	379	19	starting	starting	NN
cord-021419-nypnib0h	379	20	amine	amine	NN
cord-021419-nypnib0h	379	21	and	and	CC
cord-021419-nypnib0h	379	22	the	the	DT
cord-021419-nypnib0h	379	23	antibiotic	antibiotic	NN
cord-021419-nypnib0h	379	24	.	.	.
cord-021419-nypnib0h	380	1	The	the	DT
cord-021419-nypnib0h	380	2	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	380	3	structure	structure	NN
cord-021419-nypnib0h	380	4	was	be	VBD
cord-021419-nypnib0h	380	5	found	find	VBN
cord-021419-nypnib0h	380	6	to	to	TO
cord-021419-nypnib0h	380	7	have	have	VB
cord-021419-nypnib0h	380	8	almost	almost	RB
cord-021419-nypnib0h	380	9	no	no	DT
cord-021419-nypnib0h	380	10	effect	effect	NN
cord-021419-nypnib0h	380	11	on	on	IN
cord-021419-nypnib0h	380	12	antifungal	antifungal	JJ
cord-021419-nypnib0h	380	13	activity	activity	NN
cord-021419-nypnib0h	380	14	against	against	IN
cord-021419-nypnib0h	380	15	the	the	DT
cord-021419-nypnib0h	380	16	fungal	fungal	NN
cord-021419-nypnib0h	380	17	strains	strain	NNS
cord-021419-nypnib0h	380	18	Candida	candida	NN
cord-021419-nypnib0h	380	19	albicans	albican	NNS
cord-021419-nypnib0h	380	20	(	(	-LRB-
cord-021419-nypnib0h	380	21	ATCC	ATCC	NNP
cord-021419-nypnib0h	380	22	14053	14053	CD
cord-021419-nypnib0h	380	23	)	)	-RRB-
cord-021419-nypnib0h	380	24	,	,	,
cord-021419-nypnib0h	380	25	Cryptococcus	Cryptococcus	NNP
cord-021419-nypnib0h	380	26	humicolus	humicolus	NNP
cord-021419-nypnib0h	380	27	(	(	-LRB-
cord-021419-nypnib0h	380	28	ATCC	ATCC	NNP
cord-021419-nypnib0h	380	29	9949	9949	CD
cord-021419-nypnib0h	380	30	)	)	-RRB-
cord-021419-nypnib0h	380	31	,	,	,
cord-021419-nypnib0h	380	32	Aspergillus	Aspergillus	NNP
cord-021419-nypnib0h	380	33	niger	niger	NNP
cord-021419-nypnib0h	380	34	(	(	-LRB-
cord-021419-nypnib0h	380	35	ATCC	ATCC	NNP
cord-021419-nypnib0h	380	36	16404	16404	CD
cord-021419-nypnib0h	380	37	)	)	-RRB-
cord-021419-nypnib0h	380	38	and	and	CC
cord-021419-nypnib0h	380	39	Fusarium	Fusarium	NNP
cord-021419-nypnib0h	380	40	oxysporum	oxysporum	NNP
cord-021419-nypnib0h	380	41	(	(	-LRB-
cord-021419-nypnib0h	380	42	VKM	VKM	NNP
cord-021419-nypnib0h	380	43	F-140	f-140	NN
cord-021419-nypnib0h	380	44	)	)	-RRB-
cord-021419-nypnib0h	380	45	.	.	.
cord-021419-nypnib0h	381	1	The	the	DT
cord-021419-nypnib0h	381	2	activity	activity	NN
cord-021419-nypnib0h	381	3	in	in	IN
cord-021419-nypnib0h	381	4	each	each	DT
cord-021419-nypnib0h	381	5	pair	pair	NN
cord-021419-nypnib0h	381	6	of	of	IN
cord-021419-nypnib0h	381	7	the	the	DT
cord-021419-nypnib0h	381	8	derivatives	derivative	NNS
cord-021419-nypnib0h	381	9	containing	contain	VBG
cord-021419-nypnib0h	381	10	the	the	DT
cord-021419-nypnib0h	381	11	same	same	JJ
cord-021419-nypnib0h	381	12	substituents	substituent	NNS
cord-021419-nypnib0h	381	13	is	be	VBZ
cord-021419-nypnib0h	381	14	almost	almost	RB
cord-021419-nypnib0h	381	15	the	the	DT
cord-021419-nypnib0h	381	16	same	same	JJ
cord-021419-nypnib0h	381	17	in	in	IN
cord-021419-nypnib0h	381	18	magnitude	magnitude	NN
cord-021419-nypnib0h	381	19	.	.	.
cord-021419-nypnib0h	382	1	Carboxamides	carboxamide	NNS
cord-021419-nypnib0h	382	2	63b	63b	NNS
cord-021419-nypnib0h	382	3	,	,	,
cord-021419-nypnib0h	382	4	d	d	NNP
cord-021419-nypnib0h	382	5	,	,	,
cord-021419-nypnib0h	382	6	g	g	NN
cord-021419-nypnib0h	382	7	and	and	CC
cord-021419-nypnib0h	382	8	64b	64b	NN
cord-021419-nypnib0h	382	9	,	,	,
cord-021419-nypnib0h	383	1	e	e	LS
cord-021419-nypnib0h	383	2	,	,	,
cord-021419-nypnib0h	383	3	i	i	PRP
cord-021419-nypnib0h	383	4	were	be	VBD
cord-021419-nypnib0h	383	5	found	find	VBN
cord-021419-nypnib0h	383	6	to	to	TO
cord-021419-nypnib0h	383	7	be	be	VB
cord-021419-nypnib0h	383	8	the	the	DT
cord-021419-nypnib0h	383	9	most	most	RBS
cord-021419-nypnib0h	383	10	effective	effective	JJ
cord-021419-nypnib0h	383	11	against	against	IN
cord-021419-nypnib0h	383	12	the	the	DT
cord-021419-nypnib0h	383	13	above	above	RB
cord-021419-nypnib0h	383	14	-	-	HYPH
cord-021419-nypnib0h	383	15	mentioned	mention	VBN
cord-021419-nypnib0h	383	16	strains	strain	NNS
cord-021419-nypnib0h	383	17	(	(	-LRB-
cord-021419-nypnib0h	383	18	MIC	MIC	NNP
cord-021419-nypnib0h	383	19	50	50	CD
cord-021419-nypnib0h	383	20	&	&	CC
cord-021419-nypnib0h	383	21	0.5	0.5	CD
cord-021419-nypnib0h	383	22	±	±	CD
cord-021419-nypnib0h	383	23	2	2	CD
cord-021419-nypnib0h	383	24	mg	mg	NNP
cord-021419-nypnib0h	383	25	mL	mL	NNP
cord-021419-nypnib0h	383	26	71	71	CD
cord-021419-nypnib0h	383	27	)	)	-RRB-
cord-021419-nypnib0h	383	28	.	.	.
cord-021419-nypnib0h	384	1	The	the	DT
cord-021419-nypnib0h	384	2	major	major	JJ
cord-021419-nypnib0h	384	3	directions	direction	NNS
cord-021419-nypnib0h	384	4	of	of	IN
cord-021419-nypnib0h	384	5	chemical	chemical	JJ
cord-021419-nypnib0h	384	6	modification	modification	NN
cord-021419-nypnib0h	384	7	of	of	IN
cord-021419-nypnib0h	384	8	S44HP	s44hp	JJ
cord-021419-nypnib0h	384	9	(	(	-LRB-
cord-021419-nypnib0h	384	10	64a	64a	NN
cord-021419-nypnib0h	384	11	)	)	-RRB-
cord-021419-nypnib0h	385	1	and	and	CC
cord-021419-nypnib0h	385	2	BSG005	BSG005	NNP
cord-021419-nypnib0h	385	3	(	(	-LRB-
cord-021419-nypnib0h	385	4	65a	65a	CD
cord-021419-nypnib0h	385	5	)	)	-RRB-
cord-021419-nypnib0h	385	6	at	at	IN
cord-021419-nypnib0h	385	7	the	the	DT
cord-021419-nypnib0h	385	8	mycosamine	mycosamine	JJ
cord-021419-nypnib0h	385	9	3	3	CD
cord-021419-nypnib0h	385	10	H	H	NNP
cord-021419-nypnib0h	385	11	-amino	-amino	HYPH
cord-021419-nypnib0h	385	12	group	group	NN
cord-021419-nypnib0h	385	13	In	in	IN
cord-021419-nypnib0h	385	14	alkylation	alkylation	NN
cord-021419-nypnib0h	385	15	and	and	CC
cord-021419-nypnib0h	385	16	aminoacylation	aminoacylation	NN
cord-021419-nypnib0h	385	17	reactions	reaction	NNS
cord-021419-nypnib0h	385	18	,	,	,
cord-021419-nypnib0h	385	19	the	the	DT
cord-021419-nypnib0h	385	20	aminocontaining	aminocontaine	VBG
cord-021419-nypnib0h	385	21	reagents	reagent	NNS
cord-021419-nypnib0h	385	22	are	be	VBP
cord-021419-nypnib0h	385	23	protected	protect	VBN
cord-021419-nypnib0h	385	24	by	by	IN
cord-021419-nypnib0h	385	25	the	the	DT
cord-021419-nypnib0h	385	26	9-fluorenylmethoxycarbonyl	9-fluorenylmethoxycarbonyl	CD
cord-021419-nypnib0h	385	27	(	(	-LRB-
cord-021419-nypnib0h	385	28	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	385	29	)	)	-RRB-
cord-021419-nypnib0h	385	30	group	group	NN
cord-021419-nypnib0h	385	31	.	.	.
cord-021419-nypnib0h	386	1	Conventional	conventional	JJ
cord-021419-nypnib0h	386	2	3	3	CD
cord-021419-nypnib0h	386	3	H	h	NN
cord-021419-nypnib0h	386	4	-N	-n	NN
cord-021419-nypnib0h	386	5	-	-	HYPH
cord-021419-nypnib0h	386	6	alkyl	alkyl	JJ
cord-021419-nypnib0h	386	7	derivatives	derivative	NNS
cord-021419-nypnib0h	386	8	of	of	IN
cord-021419-nypnib0h	386	9	polyenes	polyene	NNS
cord-021419-nypnib0h	386	10	,	,	,
cord-021419-nypnib0h	386	11	such	such	JJ
cord-021419-nypnib0h	386	12	as	as	IN
cord-021419-nypnib0h	386	13	the	the	DT
cord-021419-nypnib0h	386	14	3	3	CD
cord-021419-nypnib0h	386	15	H	h	NN
cord-021419-nypnib0h	386	16	-N-(4-dimethylaminobenzyl)-substituted	-n-(4-dimethylaminobenzyl)-substituted	CD
cord-021419-nypnib0h	386	17	compounds	compound	NNS
cord-021419-nypnib0h	387	1	S44HP	s44hp	CC
cord-021419-nypnib0h	388	1	(	(	-LRB-
cord-021419-nypnib0h	388	2	64l	64l	CD
cord-021419-nypnib0h	388	3	)	)	-RRB-
cord-021419-nypnib0h	389	1	and	and	CC
cord-021419-nypnib0h	389	2	BSG005	BSG005	NNP
cord-021419-nypnib0h	389	3	(	(	-LRB-
cord-021419-nypnib0h	389	4	65c	65c	NNS
cord-021419-nypnib0h	389	5	)	)	-RRB-
cord-021419-nypnib0h	389	6	and	and	CC
cord-021419-nypnib0h	389	7	the	the	DT
cord-021419-nypnib0h	389	8	N	N	NNP
cord-021419-nypnib0h	389	9	,	,	,
cord-021419-nypnib0h	389	10	N	N	NNP
cord-021419-nypnib0h	389	11	-	-	HYPH
cord-021419-nypnib0h	389	12	di(aminopropyl)-substituted	di(aminopropyl)-substitute	VBN
cord-021419-nypnib0h	389	13	compounds	compound	NNS
cord-021419-nypnib0h	389	14	S44HP	s44hp	IN
cord-021419-nypnib0h	389	15	(	(	-LRB-
cord-021419-nypnib0h	389	16	64	64	CD
cord-021419-nypnib0h	389	17	m	m	NN
cord-021419-nypnib0h	389	18	)	)	-RRB-
cord-021419-nypnib0h	389	19	and	and	CC
cord-021419-nypnib0h	389	20	BSG005	BSG005	NNP
cord-021419-nypnib0h	389	21	(	(	-LRB-
cord-021419-nypnib0h	389	22	65d	65d	CD
cord-021419-nypnib0h	389	23	)	)	-RRB-
cord-021419-nypnib0h	389	24	,	,	,
cord-021419-nypnib0h	389	25	were	be	VBD
cord-021419-nypnib0h	389	26	synthesized	synthesize	VBN
cord-021419-nypnib0h	389	27	by	by	IN
cord-021419-nypnib0h	389	28	reductive	reductive	JJ
cord-021419-nypnib0h	389	29	alkylation	alkylation	NN
cord-021419-nypnib0h	389	30	of	of	IN
cord-021419-nypnib0h	389	31	compounds	compound	NNS
cord-021419-nypnib0h	389	32	64a	64a	NNS
cord-021419-nypnib0h	389	33	and	and	CC
cord-021419-nypnib0h	389	34	65a	65a	NNS
cord-021419-nypnib0h	389	35	with	with	IN
cord-021419-nypnib0h	389	36	appropriate	appropriate	JJ
cord-021419-nypnib0h	389	37	aldehydes	aldehyde	NNS
cord-021419-nypnib0h	389	38	in	in	IN
cord-021419-nypnib0h	389	39	the	the	DT
cord-021419-nypnib0h	389	40	presence	presence	NN
cord-021419-nypnib0h	389	41	of	of	IN
cord-021419-nypnib0h	389	42	NaCNBH	NaCNBH	NNP
cord-021419-nypnib0h	389	43	3	3	CD
cord-021419-nypnib0h	390	1	(	(	-LRB-
cord-021419-nypnib0h	390	2	see	see	VB
cord-021419-nypnib0h	390	3	Scheme	scheme	NN
cord-021419-nypnib0h	390	4	19	19	CD
cord-021419-nypnib0h	390	5	,	,	,
cord-021419-nypnib0h	390	6	conditions	condition	NNS
cord-021419-nypnib0h	390	7	b	b	NN
cord-021419-nypnib0h	390	8	and	and	CC
cord-021419-nypnib0h	390	9	c	c	NN
cord-021419-nypnib0h	390	10	)	)	-RRB-
cord-021419-nypnib0h	390	11	.	.	.
cord-021419-nypnib0h	391	1	47	47	CD
cord-021419-nypnib0h	392	1	The	the	DT
cord-021419-nypnib0h	392	2	yields	yield	NNS
cord-021419-nypnib0h	392	3	of	of	IN
cord-021419-nypnib0h	392	4	compounds	compound	NNS
cord-021419-nypnib0h	392	5	64	64	CD
cord-021419-nypnib0h	392	6	m	m	NN
cord-021419-nypnib0h	392	7	and	and	CC
cord-021419-nypnib0h	392	8	65d	65d	NNS
cord-021419-nypnib0h	392	9	with	with	IN
cord-021419-nypnib0h	392	10	respect	respect	NN
cord-021419-nypnib0h	392	11	to	to	IN
cord-021419-nypnib0h	392	12	the	the	DT
cord-021419-nypnib0h	392	13	starting	start	VBG
cord-021419-nypnib0h	392	14	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	392	15	are	be	VBP
cord-021419-nypnib0h	392	16	*	*	NFP
cord-021419-nypnib0h	392	17	12	12	CD
cord-021419-nypnib0h	392	18	%	%	NN
cord-021419-nypnib0h	392	19	±	±	CD
cord-021419-nypnib0h	392	20	20	20	CD
cord-021419-nypnib0h	392	21	%	%	NN
cord-021419-nypnib0h	392	22	.	.	.
cord-021419-nypnib0h	393	1	3	3	CD
cord-021419-nypnib0h	393	2	H	h	NN
cord-021419-nypnib0h	394	1	-N	-N	NFP
cord-021419-nypnib0h	394	2	-	-	:
cord-021419-nypnib0h	394	3	Acyl	Acyl	NNP
cord-021419-nypnib0h	394	4	derivatives	derivative	NNS
cord-021419-nypnib0h	394	5	64n	64n	NNS
cord-021419-nypnib0h	394	6	and	and	CC
cord-021419-nypnib0h	395	1	65e	65e	CD
cord-021419-nypnib0h	395	2	were	be	VBD
cord-021419-nypnib0h	395	3	synthesized	synthesize	VBN
cord-021419-nypnib0h	395	4	by	by	IN
cord-021419-nypnib0h	395	5	the	the	DT
cord-021419-nypnib0h	395	6	reaction	reaction	NN
cord-021419-nypnib0h	395	7	of	of	IN
cord-021419-nypnib0h	395	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	395	9	64a	64a	NNS
cord-021419-nypnib0h	395	10	and	and	CC
cord-021419-nypnib0h	395	11	65a	65a	NNS
cord-021419-nypnib0h	395	12	with	with	IN
cord-021419-nypnib0h	395	13	N	N	NNP
cord-021419-nypnib0h	395	14	a	a	NNP
cord-021419-nypnib0h	395	15	,	,	,
cord-021419-nypnib0h	395	16	N	N	NNP
cord-021419-nypnib0h	395	17	e	e	NN
cord-021419-nypnib0h	395	18	-(Fmoc	-(fmoc	NN
cord-021419-nypnib0h	395	19	)	)	-RRB-
cord-021419-nypnib0h	395	20	2	2	CD
cord-021419-nypnib0h	395	21	-L	-l	XX
cord-021419-nypnib0h	395	22	-	-	HYPH
cord-021419-nypnib0h	395	23	lysine	lysine	NN
cord-021419-nypnib0h	395	24	in	in	IN
cord-021419-nypnib0h	395	25	the	the	DT
cord-021419-nypnib0h	395	26	presence	presence	NN
cord-021419-nypnib0h	395	27	of	of	IN
cord-021419-nypnib0h	395	28	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	396	1	in	in	IN
cord-021419-nypnib0h	396	2	*	*	NFP
cord-021419-nypnib0h	396	3	71	71	CD
cord-021419-nypnib0h	396	4	%	%	NN
cord-021419-nypnib0h	396	5	±	±	CD
cord-021419-nypnib0h	396	6	74	74	CD
cord-021419-nypnib0h	396	7	%	%	NN
cord-021419-nypnib0h	396	8	yields	yield	NNS
cord-021419-nypnib0h	396	9	(	(	-LRB-
cord-021419-nypnib0h	396	10	see	see	VB
cord-021419-nypnib0h	396	11	Scheme	scheme	NN
cord-021419-nypnib0h	396	12	19	19	CD
cord-021419-nypnib0h	396	13	,	,	,
cord-021419-nypnib0h	396	14	conditions	condition	NNS
cord-021419-nypnib0h	396	15	d	d	NNP
cord-021419-nypnib0h	396	16	)	)	-RRB-
cord-021419-nypnib0h	396	17	.	.	.
cord-021419-nypnib0h	397	1	The	the	DT
cord-021419-nypnib0h	397	2	removal	removal	NN
cord-021419-nypnib0h	397	3	of	of	IN
cord-021419-nypnib0h	397	4	the	the	DT
cord-021419-nypnib0h	397	5	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	397	6	group	group	NN
cord-021419-nypnib0h	397	7	from	from	IN
cord-021419-nypnib0h	397	8	intermediate	intermediate	JJ
cord-021419-nypnib0h	397	9	derivatives	derivative	NNS
cord-021419-nypnib0h	397	10	64o	64o	NNS
cord-021419-nypnib0h	397	11	,	,	,
cord-021419-nypnib0h	397	12	p	p	NN
cord-021419-nypnib0h	397	13	and	and	CC
cord-021419-nypnib0h	397	14	65f	65f	NNS
cord-021419-nypnib0h	397	15	,	,	,
cord-021419-nypnib0h	397	16	g	g	NN
cord-021419-nypnib0h	397	17	with	with	IN
cord-021419-nypnib0h	397	18	a	a	DT
cord-021419-nypnib0h	397	19	5	5	CD
cord-021419-nypnib0h	397	20	%	%	NN
cord-021419-nypnib0h	397	21	piperidine	piperidine	NN
cord-021419-nypnib0h	397	22	solution	solution	NN
cord-021419-nypnib0h	397	23	in	in	IN
cord-021419-nypnib0h	397	24	DMSO	DMSO	NNP
cord-021419-nypnib0h	397	25	47	47	CD
cord-021419-nypnib0h	397	26	affords	afford	VBZ
cord-021419-nypnib0h	397	27	the	the	DT
cord-021419-nypnib0h	397	28	corresponding	corresponding	JJ
cord-021419-nypnib0h	397	29	3	3	CD
cord-021419-nypnib0h	397	30	H	h	NN
cord-021419-nypnib0h	397	31	-N	-n	NN
cord-021419-nypnib0h	397	32	-	-	HYPH
cord-021419-nypnib0h	397	33	aminoacyl	aminoacyl	VBN
cord-021419-nypnib0h	397	34	derivatives	derivative	NNS
cord-021419-nypnib0h	397	35	64m	64m	NNS
cord-021419-nypnib0h	397	36	,	,	,
cord-021419-nypnib0h	397	37	n	n	NN
cord-021419-nypnib0h	397	38	and	and	CC
cord-021419-nypnib0h	397	39	65d	65d	NNP
cord-021419-nypnib0h	397	40	,	,	,
cord-021419-nypnib0h	397	41	e	e	LS
cord-021419-nypnib0h	397	42	in	in	IN
cord-021419-nypnib0h	397	43	*	*	NFP
cord-021419-nypnib0h	397	44	11	11	CD
cord-021419-nypnib0h	397	45	%	%	NN
cord-021419-nypnib0h	397	46	±	±	CD
cord-021419-nypnib0h	397	47	20	20	CD
cord-021419-nypnib0h	397	48	%	%	NN
cord-021419-nypnib0h	397	49	yields	yield	NNS
cord-021419-nypnib0h	397	50	.	.	.
cord-021419-nypnib0h	398	1	The	the	DT
cord-021419-nypnib0h	398	2	evaluation	evaluation	NN
cord-021419-nypnib0h	398	3	of	of	IN
cord-021419-nypnib0h	398	4	the	the	DT
cord-021419-nypnib0h	398	5	influence	influence	NN
cord-021419-nypnib0h	398	6	of	of	IN
cord-021419-nypnib0h	398	7	substituents	substituent	NNS
cord-021419-nypnib0h	398	8	in	in	IN
cord-021419-nypnib0h	398	9	the	the	DT
cord-021419-nypnib0h	398	10	terminal	terminal	JJ
cord-021419-nypnib0h	398	11	group	group	NN
cord-021419-nypnib0h	398	12	at	at	IN
cord-021419-nypnib0h	398	13	the	the	DT
cord-021419-nypnib0h	398	14	C(16	C(16	NNP
cord-021419-nypnib0h	398	15	)	)	-RRB-
cord-021419-nypnib0h	398	16	atom	atom	NN
cord-021419-nypnib0h	398	17	of	of	IN
cord-021419-nypnib0h	398	18	the	the	DT
cord-021419-nypnib0h	398	19	aglycone	aglycone	NN
cord-021419-nypnib0h	398	20	and	and	CC
cord-021419-nypnib0h	398	21	the	the	DT
cord-021419-nypnib0h	398	22	mycosamine	mycosamine	JJ
cord-021419-nypnib0h	398	23	amino	amino	NNP
cord-021419-nypnib0h	398	24	group	group	NN
cord-021419-nypnib0h	398	25	on	on	IN
cord-021419-nypnib0h	398	26	the	the	DT
cord-021419-nypnib0h	398	27	antifungal	antifungal	JJ
cord-021419-nypnib0h	398	28	activity	activity	NN
cord-021419-nypnib0h	398	29	of	of	IN
cord-021419-nypnib0h	398	30	polyenes	polyene	NNS
cord-021419-nypnib0h	398	31	showed	show	VBD
cord-021419-nypnib0h	398	32	that	that	IN
cord-021419-nypnib0h	398	33	the	the	DT
cord-021419-nypnib0h	398	34	replacement	replacement	NN
cord-021419-nypnib0h	398	35	of	of	IN
cord-021419-nypnib0h	398	36	the	the	DT
cord-021419-nypnib0h	398	37	CO	CO	NNP
cord-021419-nypnib0h	398	38	2	2	CD
cord-021419-nypnib0h	398	39	H	h	NN
cord-021419-nypnib0h	398	40	group	group	NN
cord-021419-nypnib0h	398	41	by	by	IN
cord-021419-nypnib0h	398	42	Me	-PRON-	PRP
cord-021419-nypnib0h	398	43	has	have	VBZ
cord-021419-nypnib0h	398	44	no	no	DT
cord-021419-nypnib0h	398	45	significant	significant	JJ
cord-021419-nypnib0h	398	46	effect	effect	NN
cord-021419-nypnib0h	398	47	on	on	IN
cord-021419-nypnib0h	398	48	antifungal	antifungal	JJ
cord-021419-nypnib0h	398	49	activity	activity	NN
cord-021419-nypnib0h	398	50	against	against	IN
cord-021419-nypnib0h	398	51	the	the	DT
cord-021419-nypnib0h	398	52	tested	test	VBN
cord-021419-nypnib0h	398	53	strains	strain	NNS
cord-021419-nypnib0h	398	54	.	.	.
cord-021419-nypnib0h	399	1	48	48	CD
cord-021419-nypnib0h	400	1	The	the	DT
cord-021419-nypnib0h	400	2	activity	activity	NN
cord-021419-nypnib0h	400	3	of	of	IN
cord-021419-nypnib0h	400	4	S44HP	s44hp	JJ
cord-021419-nypnib0h	400	5	(	(	-LRB-
cord-021419-nypnib0h	400	6	64a	64a	NN
cord-021419-nypnib0h	400	7	)	)	-RRB-
cord-021419-nypnib0h	400	8	and	and	CC
cord-021419-nypnib0h	400	9	its	-PRON-	PRP$
cord-021419-nypnib0h	400	10	analogue	analogue	JJ
cord-021419-nypnib0h	400	11	64k	64k	NNS
cord-021419-nypnib0h	400	12	is	be	VBZ
cord-021419-nypnib0h	400	13	similar	similar	JJ
cord-021419-nypnib0h	400	14	to	to	IN
cord-021419-nypnib0h	400	15	that	that	DT
cord-021419-nypnib0h	400	16	of	of	IN
cord-021419-nypnib0h	400	17	BSG005	BSG005	NNP
cord-021419-nypnib0h	400	18	(	(	-LRB-
cord-021419-nypnib0h	400	19	65c	65c	NNS
cord-021419-nypnib0h	400	20	)	)	-RRB-
cord-021419-nypnib0h	400	21	and	and	CC
cord-021419-nypnib0h	400	22	its	-PRON-	PRP$
cord-021419-nypnib0h	400	23	analogue	analogue	NN
cord-021419-nypnib0h	400	24	65b	65b	NNS
cord-021419-nypnib0h	400	25	.	.	.
cord-021419-nypnib0h	401	1	Thus	thus	RB
cord-021419-nypnib0h	401	2	,	,	,
cord-021419-nypnib0h	401	3	the	the	DT
cord-021419-nypnib0h	401	4	effect	effect	NN
cord-021419-nypnib0h	401	5	of	of	IN
cord-021419-nypnib0h	401	6	the	the	DT
cord-021419-nypnib0h	401	7	same	same	JJ
cord-021419-nypnib0h	401	8	modifications	modification	NNS
cord-021419-nypnib0h	401	9	on	on	IN
cord-021419-nypnib0h	401	10	the	the	DT
cord-021419-nypnib0h	401	11	activity	activity	NN
cord-021419-nypnib0h	401	12	of	of	IN
cord-021419-nypnib0h	401	13	the	the	DT
cord-021419-nypnib0h	401	14	initial	initial	JJ
cord-021419-nypnib0h	401	15	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	401	16	S44HP	s44hp	IN
cord-021419-nypnib0h	401	17	and	and	CC
cord-021419-nypnib0h	401	18	BSG005	BSG005	NNP
cord-021419-nypnib0h	401	19	with	with	IN
cord-021419-nypnib0h	401	20	very	very	RB
cord-021419-nypnib0h	401	21	close	close	JJ
cord-021419-nypnib0h	401	22	values	value	NNS
cord-021419-nypnib0h	401	23	of	of	IN
cord-021419-nypnib0h	401	24	antifungal	antifungal	JJ
cord-021419-nypnib0h	401	25	activity	activity	NN
cord-021419-nypnib0h	401	26	can	can	MD
cord-021419-nypnib0h	401	27	be	be	VB
cord-021419-nypnib0h	401	28	multidirectional	multidirectional	JJ
cord-021419-nypnib0h	401	29	.	.	.
cord-021419-nypnib0h	402	1	The	the	DT
cord-021419-nypnib0h	402	2	MIC	MIC	NNP
cord-021419-nypnib0h	402	3	50	50	CD
cord-021419-nypnib0h	402	4	values	value	NNS
cord-021419-nypnib0h	402	5	are	be	VBP
cord-021419-nypnib0h	402	6	changed	change	VBN
cord-021419-nypnib0h	402	7	in	in	IN
cord-021419-nypnib0h	402	8	the	the	DT
cord-021419-nypnib0h	402	9	following	following	JJ
cord-021419-nypnib0h	402	10	series	series	NN
cord-021419-nypnib0h	402	11	:	:	:
cord-021419-nypnib0h	402	12	64a	64a	NNS
cord-021419-nypnib0h	402	13	=	=	SYM
cord-021419-nypnib0h	402	14	65a	65a	CD
cord-021419-nypnib0h	402	15	,	,	,
cord-021419-nypnib0h	402	16	64k	64k	NNS
cord-021419-nypnib0h	402	17	=	=	SYM
cord-021419-nypnib0h	402	18	65b	65b	NNS
cord-021419-nypnib0h	402	19	,	,	,
cord-021419-nypnib0h	402	20	64l	64l	CD
cord-021419-nypnib0h	402	21	>	>	XX
cord-021419-nypnib0h	402	22	65c	65c	NNS
cord-021419-nypnib0h	402	23	,	,	,
cord-021419-nypnib0h	402	24	64	64	CD
cord-021419-nypnib0h	402	25	m	m	NN
cord-021419-nypnib0h	402	26	>	>	XX
cord-021419-nypnib0h	402	27	65d	65d	NNS
cord-021419-nypnib0h	402	28	,	,	,
cord-021419-nypnib0h	402	29	64n	64n	CD
cord-021419-nypnib0h	403	1	<	<	XX
cord-021419-nypnib0h	403	2	65e	65e	XX
cord-021419-nypnib0h	403	3	.	.	.
cord-021419-nypnib0h	404	1	(	(	-LRB-
cord-021419-nypnib0h	404	2	77	77	CD
cord-021419-nypnib0h	404	3	)	)	-RRB-
cord-021419-nypnib0h	404	4	.	.	.
cord-021419-nypnib0h	405	1	The	the	DT
cord-021419-nypnib0h	405	2	removal	removal	NN
cord-021419-nypnib0h	405	3	of	of	IN
cord-021419-nypnib0h	405	4	the	the	DT
cord-021419-nypnib0h	405	5	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	405	6	protecting	protect	VBG
cord-021419-nypnib0h	405	7	group	group	NN
cord-021419-nypnib0h	405	8	from	from	IN
cord-021419-nypnib0h	405	9	compound	compound	NN
cord-021419-nypnib0h	405	10	72a	72a	NNS
cord-021419-nypnib0h	405	11	gave	give	VBD
cord-021419-nypnib0h	405	12	3	3	CD
cord-021419-nypnib0h	405	13	H	h	NN
cord-021419-nypnib0h	405	14	-N-(L	-N-(L	.
cord-021419-nypnib0h	406	1	-lysyl)-S44HP	-lysyl)-s44hp	XX
cord-021419-nypnib0h	407	1	N-(3-dimethylaminopropyl)amide	N-(3-dimethylaminopropyl)amide	NNP
cord-021419-nypnib0h	407	2	(	(	-LRB-
cord-021419-nypnib0h	407	3	72b	72b	CD
cord-021419-nypnib0h	407	4	)	)	-RRB-
cord-021419-nypnib0h	407	5	.	.	.
cord-021419-nypnib0h	408	1	49	49	CD
cord-021419-nypnib0h	409	1	An	an	DT
cord-021419-nypnib0h	409	2	alternative	alternative	JJ
cord-021419-nypnib0h	409	3	scheme	scheme	NN
cord-021419-nypnib0h	409	4	involves	involve	VBZ
cord-021419-nypnib0h	409	5	the	the	DT
cord-021419-nypnib0h	409	6	initial	initial	JJ
cord-021419-nypnib0h	409	7	synthesis	synthesis	NN
cord-021419-nypnib0h	409	8	of	of	IN
cord-021419-nypnib0h	409	9	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	409	10	-	-	HYPH
cord-021419-nypnib0h	409	11	protected	protect	VBN
cord-021419-nypnib0h	409	12	3	3	CD
cord-021419-nypnib0h	409	13	H	h	NN
cord-021419-nypnib0h	409	14	-N	-n	NN
cord-021419-nypnib0h	409	15	-	-	HYPH
cord-021419-nypnib0h	409	16	aminoacyl	aminoacyl	VBN
cord-021419-nypnib0h	409	17	derivatives	derivative	NNS
cord-021419-nypnib0h	409	18	of	of	IN
cord-021419-nypnib0h	409	19	S44HP	s44hp	RB
cord-021419-nypnib0h	409	20	followed	follow	VBN
cord-021419-nypnib0h	409	21	by	by	IN
cord-021419-nypnib0h	409	22	their	-PRON-	PRP$
cord-021419-nypnib0h	409	23	transformation	transformation	NN
cord-021419-nypnib0h	409	24	into	into	IN
cord-021419-nypnib0h	409	25	the	the	DT
cord-021419-nypnib0h	409	26	corresponding	correspond	VBG
cord-021419-nypnib0h	409	27	C(16)-carboxamides	c(16)-carboxamide	NNS
cord-021419-nypnib0h	410	1	(	(	-LRB-
cord-021419-nypnib0h	410	2	Scheme	scheme	NN
cord-021419-nypnib0h	410	3	21	21	CD
cord-021419-nypnib0h	410	4	)	)	-RRB-
cord-021419-nypnib0h	410	5	.	.	.
cord-021419-nypnib0h	411	1	The	the	DT
cord-021419-nypnib0h	411	2	reaction	reaction	NN
cord-021419-nypnib0h	411	3	of	of	IN
cord-021419-nypnib0h	411	4	compound	compound	NN
cord-021419-nypnib0h	411	5	64a	64a	NNS
cord-021419-nypnib0h	411	6	with	with	IN
cord-021419-nypnib0h	411	7	N	n	CD
cord-021419-nypnib0h	411	8	-	-	HYPH
cord-021419-nypnib0h	411	9	Fmoc-4-aminomethylbenzoic	Fmoc-4-aminomethylbenzoic	NNP
cord-021419-nypnib0h	411	10	acid	acid	NN
cord-021419-nypnib0h	411	11	in	in	IN
cord-021419-nypnib0h	411	12	the	the	DT
cord-021419-nypnib0h	411	13	presence	presence	NN
cord-021419-nypnib0h	411	14	of	of	IN
cord-021419-nypnib0h	411	15	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	411	16	affords	afford	VBZ
cord-021419-nypnib0h	411	17	3	3	CD
cord-021419-nypnib0h	411	18	H	h	NN
cord-021419-nypnib0h	411	19	-N-(N	-n-(n	NN
cord-021419-nypnib0h	411	20	-	-	:
cord-021419-nypnib0h	411	21	Fmoc-4-aminomethylbenzoyl)-S44HP	fmoc-4-aminomethylbenzoyl)-s44hp	NN
cord-021419-nypnib0h	411	22	(	(	-LRB-
cord-021419-nypnib0h	411	23	78	78	CD
cord-021419-nypnib0h	411	24	)	)	-RRB-
cord-021419-nypnib0h	411	25	.	.	.
cord-021419-nypnib0h	412	1	The	the	DT
cord-021419-nypnib0h	412	2	amidation	amidation	NN
cord-021419-nypnib0h	412	3	of	of	IN
cord-021419-nypnib0h	412	4	the	the	DT
cord-021419-nypnib0h	412	5	latter	latter	JJ
cord-021419-nypnib0h	412	6	with	with	IN
cord-021419-nypnib0h	412	7	appropriate	appropriate	JJ
cord-021419-nypnib0h	412	8	amines	amine	NNS
cord-021419-nypnib0h	412	9	in	in	IN
cord-021419-nypnib0h	412	10	the	the	DT
cord-021419-nypnib0h	412	11	presence	presence	NN
cord-021419-nypnib0h	412	12	of	of	IN
cord-021419-nypnib0h	412	13	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	412	14	gives	give	VBZ
cord-021419-nypnib0h	412	15	3	3	CD
cord-021419-nypnib0h	412	16	H	h	NN
cord-021419-nypnib0h	412	17	-N-(N	-n-(n	NN
cord-021419-nypnib0h	412	18	-	-	:
cord-021419-nypnib0h	412	19	Fmoc-4-aminomethylbenzoyl)-S44HP	fmoc-4-aminomethylbenzoyl)-s44hp	JJ
cord-021419-nypnib0h	412	20	DMAE	dmae	NN
cord-021419-nypnib0h	412	21	-	-	HYPH
cord-021419-nypnib0h	412	22	amide	amide	NN
cord-021419-nypnib0h	412	23	(	(	-LRB-
cord-021419-nypnib0h	412	24	79a	79a	CD
cord-021419-nypnib0h	412	25	)	)	-RRB-
cord-021419-nypnib0h	412	26	and	and	CC
cord-021419-nypnib0h	412	27	3-hydroxypropylamide	3-hydroxypropylamide	CD
cord-021419-nypnib0h	412	28	(	(	-LRB-
cord-021419-nypnib0h	412	29	80a	80a	NNS
cord-021419-nypnib0h	412	30	)	)	-RRB-
cord-021419-nypnib0h	412	31	.	.	.
cord-021419-nypnib0h	413	1	Known	know	VBN
cord-021419-nypnib0h	413	2	compound	compound	NN
cord-021419-nypnib0h	413	3	64p	64p	NNS
cord-021419-nypnib0h	413	4	,	,	,
cord-021419-nypnib0h	413	5	which	which	WDT
cord-021419-nypnib0h	413	6	was	be	VBD
cord-021419-nypnib0h	413	7	prepared	prepare	VBN
cord-021419-nypnib0h	413	8	by	by	IN
cord-021419-nypnib0h	413	9	the	the	DT
cord-021419-nypnib0h	413	10	reaction	reaction	NN
cord-021419-nypnib0h	413	11	of	of	IN
cord-021419-nypnib0h	413	12	64a	64a	CD
cord-021419-nypnib0h	413	13	with	with	IN
cord-021419-nypnib0h	413	14	N	N	NNP
cord-021419-nypnib0h	413	15	a	a	NNP
cord-021419-nypnib0h	413	16	,	,	,
cord-021419-nypnib0h	413	17	N	N	NNP
cord-021419-nypnib0h	413	18	e	e	NN
cord-021419-nypnib0h	413	19	-(Fmoc	-(fmoc	NN
cord-021419-nypnib0h	413	20	)	)	-RRB-
cord-021419-nypnib0h	413	21	2	2	CD
cord-021419-nypnib0h	413	22	-L	-l	ADD
cord-021419-nypnib0h	413	23	-	-	:
cord-021419-nypnib0h	413	24	Lys	Lys	NNP
cord-021419-nypnib0h	413	25	in	in	IN
cord-021419-nypnib0h	413	26	the	the	DT
cord-021419-nypnib0h	413	27	presence	presence	NN
cord-021419-nypnib0h	413	28	of	of	IN
cord-021419-nypnib0h	413	29	DCC	DCC	NNP
cord-021419-nypnib0h	413	30	and	and	CC
cord-021419-nypnib0h	413	31	HOBt	HOBt	NNP
cord-021419-nypnib0h	413	32	,	,	,
cord-021419-nypnib0h	413	33	was	be	VBD
cord-021419-nypnib0h	413	34	used	use	VBN
cord-021419-nypnib0h	413	35	to	to	TO
cord-021419-nypnib0h	413	36	synthesize	synthesize	VB
cord-021419-nypnib0h	413	37	N-(2-dimethylaminoethyl)amide	N-(2-dimethylaminoethyl)amide	NNP
cord-021419-nypnib0h	413	38	(	(	-LRB-
cord-021419-nypnib0h	413	39	81a	81a	NNS
cord-021419-nypnib0h	413	40	)	)	-RRB-
cord-021419-nypnib0h	413	41	and	and	CC
cord-021419-nypnib0h	413	42	3-hydroxypropylamide	3-hydroxypropylamide	CD
cord-021419-nypnib0h	413	43	(	(	-LRB-
cord-021419-nypnib0h	413	44	82a	82a	NNS
cord-021419-nypnib0h	413	45	)	)	-RRB-
cord-021419-nypnib0h	413	46	of	of	IN
cord-021419-nypnib0h	413	47	N	N	NNP
cord-021419-nypnib0h	413	48	a	a	NNP
cord-021419-nypnib0h	413	49	,	,	,
cord-021419-nypnib0h	414	1	N	n	NN
cord-021419-nypnib0h	414	2	e	e	NN
cord-021419-nypnib0h	414	3	-(Fmoc	-(Fmoc	VBN
cord-021419-nypnib0h	414	4	)	)	-RRB-
cord-021419-nypnib0h	414	5	2	2	CD
cord-021419-nypnib0h	414	6	-L	-l	ADD
cord-021419-nypnib0h	414	7	-	-	HYPH
cord-021419-nypnib0h	414	8	lysyl	lysyl	NN
cord-021419-nypnib0h	414	9	-	-	HYPH
cord-021419-nypnib0h	414	10	S44HP	s44hp	NN
cord-021419-nypnib0h	414	11	.	.	.
cord-021419-nypnib0h	415	1	The	the	DT
cord-021419-nypnib0h	415	2	removal	removal	NN
cord-021419-nypnib0h	415	3	of	of	IN
cord-021419-nypnib0h	415	4	the	the	DT
cord-021419-nypnib0h	415	5	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	415	6	group	group	NN
cord-021419-nypnib0h	415	7	from	from	IN
cord-021419-nypnib0h	415	8	compounds	compound	NNS
cord-021419-nypnib0h	415	9	79a	79a	CD
cord-021419-nypnib0h	415	10	±	±	CD
cord-021419-nypnib0h	415	11	82a	82a	NNS
cord-021419-nypnib0h	415	12	under	under	IN
cord-021419-nypnib0h	415	13	mild	mild	JJ
cord-021419-nypnib0h	415	14	conditions	condition	NNS
cord-021419-nypnib0h	415	15	gave	give	VBD
cord-021419-nypnib0h	415	16	target	target	NN
cord-021419-nypnib0h	415	17	products	product	NNS
cord-021419-nypnib0h	415	18	79b	79b	CD
cord-021419-nypnib0h	415	19	±	±	NNP
cord-021419-nypnib0h	415	20	82b	82b	NNS
cord-021419-nypnib0h	415	21	containing	contain	VBG
cord-021419-nypnib0h	415	22	free	free	JJ
cord-021419-nypnib0h	415	23	amino	amino	NN
cord-021419-nypnib0h	415	24	groups	group	NNS
cord-021419-nypnib0h	415	25	(	(	-LRB-
cord-021419-nypnib0h	415	26	see	see	VB
cord-021419-nypnib0h	415	27	Scheme	Scheme	NNP
cord-021419-nypnib0h	415	28	21	21	CD
cord-021419-nypnib0h	415	29	)	)	-RRB-
cord-021419-nypnib0h	415	30	.	.	.
cord-021419-nypnib0h	416	1	49	49	CD
cord-021419-nypnib0h	417	1	The	the	DT
cord-021419-nypnib0h	417	2	evaluation	evaluation	NN
cord-021419-nypnib0h	417	3	of	of	IN
cord-021419-nypnib0h	417	4	antifungal	antifungal	JJ
cord-021419-nypnib0h	417	5	activity	activity	NN
cord-021419-nypnib0h	417	6	of	of	IN
cord-021419-nypnib0h	417	7	doubly	doubly	RB
cord-021419-nypnib0h	417	8	modified	modify	VBN
cord-021419-nypnib0h	417	9	S44HP	s44hp	IN
cord-021419-nypnib0h	417	10	derivatives	derivative	NNS
cord-021419-nypnib0h	417	11	70	70	CD
cord-021419-nypnib0h	417	12	±	±	CD
cord-021419-nypnib0h	417	13	82	82	CD
cord-021419-nypnib0h	417	14	against	against	IN
cord-021419-nypnib0h	417	15	the	the	DT
cord-021419-nypnib0h	417	16	above	above	RB
cord-021419-nypnib0h	417	17	-	-	HYPH
cord-021419-nypnib0h	417	18	mentioned	mention	VBN
cord-021419-nypnib0h	417	19	four	four	CD
cord-021419-nypnib0h	417	20	fungal	fungal	JJ
cord-021419-nypnib0h	417	21	strains	strain	NNS
cord-021419-nypnib0h	417	22	compared	compare	VBN
cord-021419-nypnib0h	417	23	to	to	IN
cord-021419-nypnib0h	417	24	the	the	DT
cord-021419-nypnib0h	417	25	corresponding	correspond	VBG
cord-021419-nypnib0h	417	26	monomodified	monomodifie	VBN
cord-021419-nypnib0h	417	27	S44HP	s44hp	IN
cord-021419-nypnib0h	417	28	C(16)-carboxamides	c(16)-carboxamide	NNS
cord-021419-nypnib0h	417	29	64b	64b	NN
cord-021419-nypnib0h	417	30	,	,	,
cord-021419-nypnib0h	417	31	c	c	NNP
cord-021419-nypnib0h	417	32	demonstrated	demonstrate	VBD
cord-021419-nypnib0h	417	33	that	that	IN
cord-021419-nypnib0h	417	34	the	the	DT
cord-021419-nypnib0h	417	35	additional	additional	JJ
cord-021419-nypnib0h	417	36	modification	modification	NN
cord-021419-nypnib0h	417	37	of	of	IN
cord-021419-nypnib0h	417	38	the	the	DT
cord-021419-nypnib0h	417	39	mycosamine	mycosamine	JJ
cord-021419-nypnib0h	417	40	3	3	CD
cord-021419-nypnib0h	417	41	H	H	NNP
cord-021419-nypnib0h	417	42	-amino	-amino	HYPH
cord-021419-nypnib0h	417	43	group	group	NN
cord-021419-nypnib0h	417	44	of	of	IN
cord-021419-nypnib0h	417	45	carboxamide	carboxamide	NNP
cord-021419-nypnib0h	417	46	64b	64b	NNPS
cord-021419-nypnib0h	417	47	has	have	VBZ
cord-021419-nypnib0h	417	48	no	no	DT
cord-021419-nypnib0h	417	49	significant	significant	JJ
cord-021419-nypnib0h	417	50	effect	effect	NN
cord-021419-nypnib0h	417	51	on	on	IN
cord-021419-nypnib0h	417	52	antifungal	antifungal	JJ
cord-021419-nypnib0h	417	53	activity	activity	NN
cord-021419-nypnib0h	417	54	against	against	IN
cord-021419-nypnib0h	417	55	these	these	DT
cord-021419-nypnib0h	417	56	fungal	fungal	NN
cord-021419-nypnib0h	417	57	and	and	CC
cord-021419-nypnib0h	417	58	yeast	yeast	NN
cord-021419-nypnib0h	417	59	strains	strain	NNS
cord-021419-nypnib0h	417	60	(	(	-LRB-
cord-021419-nypnib0h	417	61	MIC	mic	NN
cord-021419-nypnib0h	417	62	*	*	NFP
cord-021419-nypnib0h	418	1	0.5	0.5	CD
cord-021419-nypnib0h	418	2	±	±	CD
cord-021419-nypnib0h	418	3	2	2	CD
cord-021419-nypnib0h	419	1	mg	mg	NN
cord-021419-nypnib0h	419	2	mL	mL	NNP
cord-021419-nypnib0h	419	3	71	71	CD
cord-021419-nypnib0h	419	4	)	)	-RRB-
cord-021419-nypnib0h	419	5	.	.	.
cord-021419-nypnib0h	420	1	Meanwhile	meanwhile	RB
cord-021419-nypnib0h	420	2	,	,	,
cord-021419-nypnib0h	420	3	the	the	DT
cord-021419-nypnib0h	420	4	corresponding	corresponding	JJ
cord-021419-nypnib0h	420	5	modifications	modification	NNS
cord-021419-nypnib0h	420	6	of	of	IN
cord-021419-nypnib0h	420	7	S44HP	s44hp	IN
cord-021419-nypnib0h	420	8	3-hydroxypropylamide	3-hydroxypropylamide	CD
cord-021419-nypnib0h	420	9	lead	lead	VB
cord-021419-nypnib0h	420	10	to	to	IN
cord-021419-nypnib0h	420	11	a	a	DT
cord-021419-nypnib0h	420	12	considerable	considerable	JJ
cord-021419-nypnib0h	420	13	decrease	decrease	NN
cord-021419-nypnib0h	420	14	in	in	IN
cord-021419-nypnib0h	420	15	antifungal	antifungal	JJ
cord-021419-nypnib0h	420	16	activity	activity	NN
cord-021419-nypnib0h	420	17	.	.	.
cord-021419-nypnib0h	421	1	In	in	IN
cord-021419-nypnib0h	421	2	the	the	DT
cord-021419-nypnib0h	421	3	series	series	NN
cord-021419-nypnib0h	421	4	of	of	IN
cord-021419-nypnib0h	421	5	doubly	doubly	RB
cord-021419-nypnib0h	421	6	modified	modify	VBN
cord-021419-nypnib0h	421	7	derivatives	derivative	NNS
cord-021419-nypnib0h	421	8	,	,	,
cord-021419-nypnib0h	422	1	S44HP	s44hp	IN
cord-021419-nypnib0h	422	2	2-N	2-n	CD
cord-021419-nypnib0h	422	3	,	,	,
cord-021419-nypnib0h	422	4	N	n	CD
cord-021419-nypnib0h	422	5	-	-	HYPH
cord-021419-nypnib0h	422	6	dimethylethylamides	dimethylethylamides	NNP
cord-021419-nypnib0h	422	7	(	(	-LRB-
cord-021419-nypnib0h	422	8	73	73	CD
cord-021419-nypnib0h	422	9	and	and	CC
cord-021419-nypnib0h	422	10	74	74	CD
cord-021419-nypnib0h	422	11	,	,	,
cord-021419-nypnib0h	422	12	respectively	respectively	RB
cord-021419-nypnib0h	422	13	)	)	-RRB-
cord-021419-nypnib0h	422	14	,	,	,
cord-021419-nypnib0h	422	15	prepared	prepare	VBN
cord-021419-nypnib0h	422	16	via	via	IN
cord-021419-nypnib0h	422	17	the	the	DT
cord-021419-nypnib0h	422	18	Amadori	Amadori	NNP
cord-021419-nypnib0h	422	19	rearrangement	rearrangement	NN
cord-021419-nypnib0h	422	20	with	with	IN
cord-021419-nypnib0h	422	21	D	d	NN
cord-021419-nypnib0h	422	22	-	-	HYPH
cord-021419-nypnib0h	422	23	glucose	glucose	NN
cord-021419-nypnib0h	422	24	or	or	CC
cord-021419-nypnib0h	422	25	D	d	NN
cord-021419-nypnib0h	422	26	-	-	HYPH
cord-021419-nypnib0h	422	27	galactose	galactose	NN
cord-021419-nypnib0h	422	28	,	,	,
cord-021419-nypnib0h	422	29	exhibit	exhibit	VB
cord-021419-nypnib0h	422	30	the	the	DT
cord-021419-nypnib0h	422	31	highest	high	JJS
cord-021419-nypnib0h	422	32	activity	activity	NN
cord-021419-nypnib0h	422	33	,	,	,
cord-021419-nypnib0h	422	34	similar	similar	JJ
cord-021419-nypnib0h	422	35	to	to	IN
cord-021419-nypnib0h	422	36	that	that	DT
cord-021419-nypnib0h	422	37	of	of	IN
cord-021419-nypnib0h	422	38	the	the	DT
cord-021419-nypnib0h	422	39	starting	start	VBG
cord-021419-nypnib0h	422	40	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	422	41	63a	63a	NNS
cord-021419-nypnib0h	422	42	and	and	CC
cord-021419-nypnib0h	422	43	64a	64a	NNS
cord-021419-nypnib0h	422	44	.	.	.
cord-021419-nypnib0h	423	1	49	49	CD
cord-021419-nypnib0h	423	2	Experiments	experiment	NNS
cord-021419-nypnib0h	423	3	in	in	IN
cord-021419-nypnib0h	423	4	animals	animal	NNS
cord-021419-nypnib0h	423	5	play	play	VBP
cord-021419-nypnib0h	423	6	a	a	DT
cord-021419-nypnib0h	423	7	significant	significant	JJ
cord-021419-nypnib0h	423	8	role	role	NN
cord-021419-nypnib0h	423	9	in	in	IN
cord-021419-nypnib0h	423	10	the	the	DT
cord-021419-nypnib0h	423	11	selection	selection	NN
cord-021419-nypnib0h	423	12	of	of	IN
cord-021419-nypnib0h	423	13	lead	lead	JJ
cord-021419-nypnib0h	423	14	antifungal	antifungal	JJ
cord-021419-nypnib0h	423	15	agents	agent	NNS
cord-021419-nypnib0h	423	16	.	.	.
cord-021419-nypnib0h	424	1	Since	since	IN
cord-021419-nypnib0h	424	2	only	only	RB
cord-021419-nypnib0h	424	3	rather	rather	RB
cord-021419-nypnib0h	424	4	toxic	toxic	JJ
cord-021419-nypnib0h	424	5	AmB	amb	NN
cord-021419-nypnib0h	424	6	(	(	-LRB-
cord-021419-nypnib0h	424	7	63a	63a	NNP
cord-021419-nypnib0h	424	8	)	)	-RRB-
cord-021419-nypnib0h	424	9	is	be	VBZ
cord-021419-nypnib0h	424	10	used	use	VBN
cord-021419-nypnib0h	424	11	for	for	IN
cord-021419-nypnib0h	424	12	the	the	DT
cord-021419-nypnib0h	424	13	treatment	treatment	NN
cord-021419-nypnib0h	424	14	of	of	IN
cord-021419-nypnib0h	424	15	systemic	systemic	JJ
cord-021419-nypnib0h	424	16	fungal	fungal	JJ
cord-021419-nypnib0h	424	17	infections	infection	NNS
cord-021419-nypnib0h	424	18	,	,	,
cord-021419-nypnib0h	424	19	compounds	compound	NNS
cord-021419-nypnib0h	424	20	exhibiting	exhibit	VBG
cord-021419-nypnib0h	424	21	the	the	DT
cord-021419-nypnib0h	424	22	highest	high	JJS
cord-021419-nypnib0h	424	23	in	in	IN
cord-021419-nypnib0h	424	24	vitro	vitro	FW
cord-021419-nypnib0h	424	25	activity	activity	NN
cord-021419-nypnib0h	424	26	are	be	VBP
cord-021419-nypnib0h	424	27	currently	currently	RB
cord-021419-nypnib0h	424	28	tested	test	VBN
cord-021419-nypnib0h	424	29	for	for	IN
cord-021419-nypnib0h	424	30	the	the	DT
cord-021419-nypnib0h	424	31	haemolysis	haemolysis	NNP
cord-021419-nypnib0h	424	32	and(or	and(or	NNP
cord-021419-nypnib0h	424	33	)	)	-RRB-
cord-021419-nypnib0h	424	34	acute	acute	JJ
cord-021419-nypnib0h	424	35	toxicity	toxicity	NN
cord-021419-nypnib0h	424	36	.	.	.
cord-021419-nypnib0h	425	1	New	new	JJ
cord-021419-nypnib0h	425	2	genetically	genetically	RB
cord-021419-nypnib0h	425	3	engineered	engineer	VBN
cord-021419-nypnib0h	425	4	polyene	polyene	NNP
cord-021419-nypnib0h	425	5	macrolides	macrolide	NNS
cord-021419-nypnib0h	425	6	64a	64a	NNS
cord-021419-nypnib0h	425	7	,	,	,
cord-021419-nypnib0h	425	8	65a	65a	CD
cord-021419-nypnib0h	425	9	,	,	,
cord-021419-nypnib0h	425	10	66a	66a	NN
cord-021419-nypnib0h	425	11	and	and	CC
cord-021419-nypnib0h	425	12	68a	68a	NNS
cord-021419-nypnib0h	425	13	,	,	,
cord-021419-nypnib0h	425	14	the	the	DT
cord-021419-nypnib0h	425	15	semi	semi	JJ
cord-021419-nypnib0h	425	16	-	-	JJ
cord-021419-nypnib0h	425	17	synthetic	synthetic	JJ
cord-021419-nypnib0h	425	18	derivatives	derivative	NNS
cord-021419-nypnib0h	425	19	DMAE	DMAE	NNP
cord-021419-nypnib0h	426	1	-S44HP	-S44HP	NNP
cord-021419-nypnib0h	426	2	(	(	-LRB-
cord-021419-nypnib0h	426	3	64b	64b	NNS
cord-021419-nypnib0h	426	4	)	)	-RRB-
cord-021419-nypnib0h	426	5	,	,	,
cord-021419-nypnib0h	426	6	3	3	CD
cord-021419-nypnib0h	426	7	H	h	NN
cord-021419-nypnib0h	427	1	-N	-N	NFP
cord-021419-nypnib0h	427	2	-	-	:
cord-021419-nypnib0h	427	3	Lys	Lys	NNP
cord-021419-nypnib0h	427	4	-	-	HYPH
cord-021419-nypnib0h	427	5	BSG005	BSG005	NNP
cord-021419-nypnib0h	427	6	(	(	-LRB-
cord-021419-nypnib0h	427	7	65e	65e	CD
cord-021419-nypnib0h	427	8	)	)	-RRB-
cord-021419-nypnib0h	427	9	and	and	CC
cord-021419-nypnib0h	427	10	doubly	doubly	RB
cord-021419-nypnib0h	427	11	modified	modify	VBN
cord-021419-nypnib0h	427	12	3	3	CD
cord-021419-nypnib0h	427	13	H	h	NN
cord-021419-nypnib0h	427	14	-N-(1deoxy	-n-(1deoxy	NN
cord-021419-nypnib0h	427	15	-	-	HYPH
cord-021419-nypnib0h	427	16	D	D	NNP
cord-021419-nypnib0h	427	17	-	-	HYPH
cord-021419-nypnib0h	427	18	fructos-1-yl)-S44HP	fructos-1-yl)-s44hp	JJ
cord-021419-nypnib0h	427	19	DMAE	DMAE	NNP
cord-021419-nypnib0h	427	20	(	(	-LRB-
cord-021419-nypnib0h	427	21	73	73	CD
cord-021419-nypnib0h	427	22	)	)	-RRB-
cord-021419-nypnib0h	427	23	were	be	VBD
cord-021419-nypnib0h	427	24	evaluated	evaluate	VBN
cord-021419-nypnib0h	427	25	for	for	IN
cord-021419-nypnib0h	427	26	antifungal	antifungal	JJ
cord-021419-nypnib0h	427	27	activity	activity	NN
cord-021419-nypnib0h	427	28	in	in	IN
cord-021419-nypnib0h	427	29	the	the	DT
cord-021419-nypnib0h	427	30	treatment	treatment	NN
cord-021419-nypnib0h	427	31	of	of	IN
cord-021419-nypnib0h	427	32	Candida	Candida	NNP
cord-021419-nypnib0h	427	33	albicansinduced	albicansinduce	VBD
cord-021419-nypnib0h	427	34	sepsis	sepsis	NN
cord-021419-nypnib0h	427	35	in	in	IN
cord-021419-nypnib0h	427	36	mice	mouse	NNS
cord-021419-nypnib0h	427	37	and	and	CC
cord-021419-nypnib0h	427	38	tested	test	VBN
cord-021419-nypnib0h	427	39	for	for	IN
cord-021419-nypnib0h	427	40	toxicity	toxicity	NN
cord-021419-nypnib0h	427	41	.	.	.
cord-021419-nypnib0h	428	1	47	47	CD
cord-021419-nypnib0h	428	2	,	,	,
cord-021419-nypnib0h	428	3	49	49	CD
cord-021419-nypnib0h	429	1	The	the	DT
cord-021419-nypnib0h	429	2	largest	large	JJS
cord-021419-nypnib0h	429	3	margin	margin	NN
cord-021419-nypnib0h	429	4	between	between	IN
cord-021419-nypnib0h	429	5	the	the	DT
cord-021419-nypnib0h	429	6	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	429	7	and	and	CC
cord-021419-nypnib0h	429	8	toxic	toxic	JJ
cord-021419-nypnib0h	429	9	doses	dose	NNS
cord-021419-nypnib0h	429	10	was	be	VBD
cord-021419-nypnib0h	429	11	observed	observe	VBN
cord-021419-nypnib0h	429	12	for	for	IN
cord-021419-nypnib0h	429	13	compounds	compound	NNS
cord-021419-nypnib0h	429	14	64b	64b	,
cord-021419-nypnib0h	429	15	and	and	CC
cord-021419-nypnib0h	429	16	73	73	CD
cord-021419-nypnib0h	429	17	.	.	.
cord-021419-nypnib0h	430	1	compounds	compound	NNS
cord-021419-nypnib0h	430	2	,	,	,
cord-021419-nypnib0h	430	3	the	the	DT
cord-021419-nypnib0h	430	4	effective	effective	JJ
cord-021419-nypnib0h	430	5	dose	dose	NN
cord-021419-nypnib0h	430	6	was	be	VBD
cord-021419-nypnib0h	430	7	2	2	CD
cord-021419-nypnib0h	430	8	%	%	NN
cord-021419-nypnib0h	430	9	and	and	CC
cord-021419-nypnib0h	430	10	6	6	CD
cord-021419-nypnib0h	430	11	%	%	NN
cord-021419-nypnib0h	430	12	of	of	IN
cord-021419-nypnib0h	430	13	the	the	DT
cord-021419-nypnib0h	430	14	maximum	maximum	NN
cord-021419-nypnib0h	430	15	tolerated	tolerate	VBN
cord-021419-nypnib0h	430	16	dose	dose	NN
cord-021419-nypnib0h	430	17	(	(	-LRB-
cord-021419-nypnib0h	430	18	MTD	MTD	NNP
cord-021419-nypnib0h	430	19	)	)	-RRB-
cord-021419-nypnib0h	430	20	,	,	,
cord-021419-nypnib0h	430	21	respectively	respectively	RB
cord-021419-nypnib0h	430	22	,	,	,
cord-021419-nypnib0h	430	23	whereas	whereas	IN
cord-021419-nypnib0h	430	24	AmB	amb	NN
cord-021419-nypnib0h	430	25	(	(	-LRB-
cord-021419-nypnib0h	430	26	63a	63a	NNP
cord-021419-nypnib0h	430	27	)	)	-RRB-
cord-021419-nypnib0h	430	28	is	be	VBZ
cord-021419-nypnib0h	430	29	effective	effective	JJ
cord-021419-nypnib0h	430	30	only	only	RB
cord-021419-nypnib0h	430	31	at	at	IN
cord-021419-nypnib0h	430	32	a	a	DT
cord-021419-nypnib0h	430	33	dose	dose	NN
cord-021419-nypnib0h	430	34	of	of	IN
cord-021419-nypnib0h	430	35	62	62	CD
cord-021419-nypnib0h	430	36	%	%	NN
cord-021419-nypnib0h	430	37	of	of	IN
cord-021419-nypnib0h	430	38	MTD	MTD	NNP
cord-021419-nypnib0h	430	39	.	.	.
cord-021419-nypnib0h	431	1	The	the	DT
cord-021419-nypnib0h	431	2	antifungal	antifungal	JJ
cord-021419-nypnib0h	431	3	activity	activity	NN
cord-021419-nypnib0h	431	4	of	of	IN
cord-021419-nypnib0h	431	5	C(16)-methyl	C(16)-methyl	NNP
cord-021419-nypnib0h	431	6	-	-	HYPH
cord-021419-nypnib0h	431	7	C(16)-decarboxypolyenes	C(16)-decarboxypolyenes	NNPS
cord-021419-nypnib0h	431	8	against	against	IN
cord-021419-nypnib0h	431	9	four	four	CD
cord-021419-nypnib0h	431	10	fungal	fungal	JJ
cord-021419-nypnib0h	431	11	strains	strain	NNS
cord-021419-nypnib0h	431	12	changes	change	NNS
cord-021419-nypnib0h	431	13	in	in	IN
cord-021419-nypnib0h	431	14	the	the	DT
cord-021419-nypnib0h	431	15	following	following	JJ
cord-021419-nypnib0h	431	16	order	order	NN
cord-021419-nypnib0h	431	17	:	:	:
cord-021419-nypnib0h	432	1	BSG005	BSG005	NNP
cord-021419-nypnib0h	432	2	[	[	-LRB-
cord-021419-nypnib0h	432	3	C(7	C(7	NNP
cord-021419-nypnib0h	432	4	)	)	-RRB-
cord-021419-nypnib0h	432	5	,	,	,
cord-021419-nypnib0h	432	6	C(10	C(10	NNP
cord-021419-nypnib0h	432	7	)	)	-RRB-
cord-021419-nypnib0h	432	8	]	]	-RRB-
cord-021419-nypnib0h	433	1	(	(	-LRB-
cord-021419-nypnib0h	433	2	65a	65a	CD
cord-021419-nypnib0h	433	3	)	)	-RRB-
cord-021419-nypnib0h	434	1	>	>	XX
cord-021419-nypnib0h	435	1	BSG019	BSG019	NNP
cord-021419-nypnib0h	436	1	[	[	-LRB-
cord-021419-nypnib0h	436	2	C(7	C(7	NNP
cord-021419-nypnib0h	436	3	)	)	-RRB-
cord-021419-nypnib0h	436	4	]	]	-RRB-
cord-021419-nypnib0h	437	1	(	(	-LRB-
cord-021419-nypnib0h	437	2	67	67	CD
cord-021419-nypnib0h	437	3	)	)	-RRB-
cord-021419-nypnib0h	438	1	>	>	XX
cord-021419-nypnib0h	439	1	BSG018	BSG018	NNP
cord-021419-nypnib0h	439	2	[	[	-LRB-
cord-021419-nypnib0h	439	3	C(7	C(7	NNP
cord-021419-nypnib0h	439	4	)	)	-RRB-
cord-021419-nypnib0h	439	5	,	,	,
cord-021419-nypnib0h	439	6	C(9	C(9	NNP
cord-021419-nypnib0h	439	7	)	)	-RRB-
cord-021419-nypnib0h	439	8	]	]	-RRB-
cord-021419-nypnib0h	440	1	(	(	-LRB-
cord-021419-nypnib0h	440	2	69	69	CD
cord-021419-nypnib0h	440	3	)	)	-RRB-
cord-021419-nypnib0h	440	4	.	.	.
cord-021419-nypnib0h	441	1	48	48	CD
cord-021419-nypnib0h	442	1	This	this	DT
cord-021419-nypnib0h	442	2	confirms	confirm	VBZ
cord-021419-nypnib0h	442	3	the	the	DT
cord-021419-nypnib0h	442	4	pattern	pattern	NN
cord-021419-nypnib0h	442	5	of	of	IN
cord-021419-nypnib0h	442	6	changes	change	NNS
cord-021419-nypnib0h	442	7	in	in	IN
cord-021419-nypnib0h	442	8	the	the	DT
cord-021419-nypnib0h	442	9	activity	activity	NN
cord-021419-nypnib0h	442	10	against	against	IN
cord-021419-nypnib0h	442	11	C.	C.	NNP
cord-021419-nypnib0h	442	12	albicans	albican	NNS
cord-021419-nypnib0h	442	13	observed	observe	VBN
cord-021419-nypnib0h	442	14	previously	previously	RB
cord-021419-nypnib0h	442	15	in	in	IN
cord-021419-nypnib0h	442	16	the	the	DT
cord-021419-nypnib0h	442	17	series	series	NN
cord-021419-nypnib0h	442	18	of	of	IN
cord-021419-nypnib0h	442	19	C(16)-carboxy	C(16)-carboxy	NNP
cord-021419-nypnib0h	442	20	-	-	HYPH
cord-021419-nypnib0h	442	21	containing	contain	VBG
cord-021419-nypnib0h	442	22	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	442	23	with	with	IN
cord-021419-nypnib0h	442	24	a	a	DT
cord-021419-nypnib0h	442	25	similar	similar	JJ
cord-021419-nypnib0h	442	26	arrangement	arrangement	NN
cord-021419-nypnib0h	442	27	of	of	IN
cord-021419-nypnib0h	442	28	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	442	29	groups	group	NNS
cord-021419-nypnib0h	442	30	at	at	IN
cord-021419-nypnib0h	442	31	C(7)7C(10	C(7)7C(10	NNP
cord-021419-nypnib0h	442	32	)	)	-RRB-
cord-021419-nypnib0h	442	33	:	:	:
cord-021419-nypnib0h	443	1	S44HP	s44hp	CC
cord-021419-nypnib0h	443	2	(	(	-LRB-
cord-021419-nypnib0h	443	3	64a	64a	NN
cord-021419-nypnib0h	443	4	)	)	-RRB-
cord-021419-nypnib0h	444	1	>	>	XX
cord-021419-nypnib0h	444	2	BSG022	BSG022	NNP
cord-021419-nypnib0h	444	3	(	(	-LRB-
cord-021419-nypnib0h	444	4	66	66	CD
cord-021419-nypnib0h	444	5	)	)	-RRB-
cord-021419-nypnib0h	444	6	[	[	-LRB-
cord-021419-nypnib0h	444	7	C(7	C(7	NNP
cord-021419-nypnib0h	444	8	)	)	-RRB-
cord-021419-nypnib0h	444	9	]	]	-RRB-
cord-021419-nypnib0h	445	1	>	>	XX
cord-021419-nypnib0h	446	1	BSG003	BSG003	NNP
cord-021419-nypnib0h	446	2	(	(	-LRB-
cord-021419-nypnib0h	446	3	68a	68a	CD
cord-021419-nypnib0h	446	4	)	)	-RRB-
cord-021419-nypnib0h	447	1	[	[	-LRB-
cord-021419-nypnib0h	447	2	C(7	C(7	NNP
cord-021419-nypnib0h	447	3	)	)	-RRB-
cord-021419-nypnib0h	447	4	,	,	,
cord-021419-nypnib0h	447	5	C(9	C(9	NNP
cord-021419-nypnib0h	447	6	)	)	-RRB-
cord-021419-nypnib0h	447	7	]	]	-RRB-
cord-021419-nypnib0h	447	8	.	.	.
cord-021419-nypnib0h	448	1	50	50	CD
cord-021419-nypnib0h	449	1	The	the	DT
cord-021419-nypnib0h	449	2	following	following	JJ
cord-021419-nypnib0h	449	3	amides	amide	NNS
cord-021419-nypnib0h	449	4	were	be	VBD
cord-021419-nypnib0h	449	5	synthesized	synthesize	VBN
cord-021419-nypnib0h	449	6	from	from	IN
cord-021419-nypnib0h	449	7	polyenes	polyene	NNS
cord-021419-nypnib0h	449	8	64a	64a	NNS
cord-021419-nypnib0h	449	9	,	,	,
cord-021419-nypnib0h	449	10	66a	66a	NN
cord-021419-nypnib0h	449	11	and	and	CC
cord-021419-nypnib0h	449	12	68a	68a	NNS
cord-021419-nypnib0h	450	1	and	and	CC
cord-021419-nypnib0h	450	2	2-(N	2-(n	CD
cord-021419-nypnib0h	450	3	,	,	,
cord-021419-nypnib0h	450	4	N	N	NNP
cord-021419-nypnib0h	450	5	-	-	HYPH
cord-021419-nypnib0h	450	6	dimethylamino)ethylamine	dimethylamino)ethylamine	NNP
cord-021419-nypnib0h	450	7	according	accord	VBG
cord-021419-nypnib0h	450	8	to	to	IN
cord-021419-nypnib0h	450	9	the	the	DT
cord-021419-nypnib0h	450	10	conventional	conventional	JJ
cord-021419-nypnib0h	450	11	amidation	amidation	NN
cord-021419-nypnib0h	450	12	method	method	NN
cord-021419-nypnib0h	450	13	in	in	IN
cord-021419-nypnib0h	450	14	the	the	DT
cord-021419-nypnib0h	450	15	presence	presence	NN
cord-021419-nypnib0h	450	16	of	of	IN
cord-021419-nypnib0h	450	17	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	450	18	:	:	:
cord-021419-nypnib0h	451	1	DMAE	DMAE	NNP
cord-021419-nypnib0h	451	2	-	-	HYPH
cord-021419-nypnib0h	451	3	S44HP	s44hp	JJ
cord-021419-nypnib0h	451	4	(	(	-LRB-
cord-021419-nypnib0h	451	5	64b	64b	NN
cord-021419-nypnib0h	451	6	)	)	-RRB-
cord-021419-nypnib0h	451	7	,	,	,
cord-021419-nypnib0h	451	8	DMAE	DMAE	NNP
cord-021419-nypnib0h	451	9	-	-	HYPH
cord-021419-nypnib0h	451	10	BSG022	BSG022	NNP
cord-021419-nypnib0h	451	11	(	(	-LRB-
cord-021419-nypnib0h	451	12	66b	66b	NNS
cord-021419-nypnib0h	451	13	)	)	-RRB-
cord-021419-nypnib0h	451	14	and	and	CC
cord-021419-nypnib0h	451	15	DMAE	DMAE	NNP
cord-021419-nypnib0h	451	16	-	-	HYPH
cord-021419-nypnib0h	451	17	BSG003	BSG003	NNP
cord-021419-nypnib0h	451	18	(	(	-LRB-
cord-021419-nypnib0h	451	19	68b	68b	NNS
cord-021419-nypnib0h	451	20	)	)	-RRB-
cord-021419-nypnib0h	452	1	(	(	-LRB-
cord-021419-nypnib0h	452	2	see	see	VB
cord-021419-nypnib0h	452	3	Scheme	Scheme	NNP
cord-021419-nypnib0h	452	4	17	17	CD
cord-021419-nypnib0h	452	5	)	)	-RRB-
cord-021419-nypnib0h	452	6	.	.	.
cord-021419-nypnib0h	453	1	47	47	CD
cord-021419-nypnib0h	453	2	,	,	,
cord-021419-nypnib0h	453	3	48	48	CD
cord-021419-nypnib0h	454	1	The	the	DT
cord-021419-nypnib0h	454	2	activity	activity	NN
cord-021419-nypnib0h	454	3	of	of	IN
cord-021419-nypnib0h	454	4	these	these	DT
cord-021419-nypnib0h	454	5	compounds	compound	NNS
cord-021419-nypnib0h	454	6	,	,	,
cord-021419-nypnib0h	454	7	like	like	IN
cord-021419-nypnib0h	454	8	that	that	DT
cord-021419-nypnib0h	454	9	of	of	IN
cord-021419-nypnib0h	454	10	the	the	DT
cord-021419-nypnib0h	454	11	starting	start	VBG
cord-021419-nypnib0h	454	12	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	454	13	,	,	,
cord-021419-nypnib0h	454	14	changes	change	NNS
cord-021419-nypnib0h	454	15	in	in	IN
cord-021419-nypnib0h	454	16	a	a	DT
cord-021419-nypnib0h	454	17	similar	similar	JJ
cord-021419-nypnib0h	454	18	series	series	NN
cord-021419-nypnib0h	454	19	:	:	:
cord-021419-nypnib0h	455	1	DMAE	DMAE	NNP
cord-021419-nypnib0h	455	2	-	-	HYPH
cord-021419-nypnib0h	455	3	S44HP	s44hp	JJ
cord-021419-nypnib0h	455	4	(	(	-LRB-
cord-021419-nypnib0h	455	5	64b	64b	NN
cord-021419-nypnib0h	455	6	)	)	-RRB-
cord-021419-nypnib0h	455	7	>	>	NFP
cord-021419-nypnib0h	455	8	DMAE	DMAE	NNP
cord-021419-nypnib0h	455	9	-	-	HYPH
cord-021419-nypnib0h	455	10	BSG022	BSG022	NNP
cord-021419-nypnib0h	455	11	(	(	-LRB-
cord-021419-nypnib0h	455	12	66b	66b	CD
cord-021419-nypnib0h	455	13	)	)	-RRB-
cord-021419-nypnib0h	456	1	>	>	XX
cord-021419-nypnib0h	457	1	DMPE	DMPE	NNP
cord-021419-nypnib0h	457	2	-	-	HYPH
cord-021419-nypnib0h	457	3	BSG003	BSG003	NNP
cord-021419-nypnib0h	457	4	(	(	-LRB-
cord-021419-nypnib0h	457	5	68b	68b	NNS
cord-021419-nypnib0h	457	6	)	)	-RRB-
cord-021419-nypnib0h	457	7	.	.	.
cord-021419-nypnib0h	458	1	It	-PRON-	PRP
cord-021419-nypnib0h	458	2	is	be	VBZ
cord-021419-nypnib0h	458	3	worth	worth	JJ
cord-021419-nypnib0h	458	4	noting	note	VBG
cord-021419-nypnib0h	458	5	that	that	IN
cord-021419-nypnib0h	458	6	low	low	JJ
cord-021419-nypnib0h	458	7	antifungal	antifungal	JJ
cord-021419-nypnib0h	458	8	activity	activity	NN
cord-021419-nypnib0h	458	9	of	of	IN
cord-021419-nypnib0h	458	10	compounds	compound	NNS
cord-021419-nypnib0h	458	11	66b	66b	NNS
cord-021419-nypnib0h	458	12	and	and	CC
cord-021419-nypnib0h	458	13	68b	68b	NNS
cord-021419-nypnib0h	458	14	was	be	VBD
cord-021419-nypnib0h	458	15	confirmed	confirm	VBN
cord-021419-nypnib0h	458	16	also	also	RB
cord-021419-nypnib0h	458	17	by	by	IN
cord-021419-nypnib0h	458	18	animal	animal	NN
cord-021419-nypnib0h	458	19	experiments	experiment	NNS
cord-021419-nypnib0h	458	20	related	relate	VBN
cord-021419-nypnib0h	458	21	to	to	IN
cord-021419-nypnib0h	458	22	the	the	DT
cord-021419-nypnib0h	458	23	treatment	treatment	NN
cord-021419-nypnib0h	458	24	of	of	IN
cord-021419-nypnib0h	458	25	murine	murine	JJ
cord-021419-nypnib0h	458	26	Candida	Candida	NNP
cord-021419-nypnib0h	458	27	sepsis	sepsis	NN
cord-021419-nypnib0h	458	28	.	.	.
cord-021419-nypnib0h	459	1	These	these	DT
cord-021419-nypnib0h	459	2	studies	study	NNS
cord-021419-nypnib0h	459	3	clearly	clearly	RB
cord-021419-nypnib0h	459	4	demonstrated	demonstrate	VBD
cord-021419-nypnib0h	459	5	that	that	IN
cord-021419-nypnib0h	459	6	the	the	DT
cord-021419-nypnib0h	459	7	C(7)7C(10	C(7)7C(10	NNP
cord-021419-nypnib0h	459	8	)	)	-RRB-
cord-021419-nypnib0h	459	9	group	group	NN
cord-021419-nypnib0h	459	10	of	of	IN
cord-021419-nypnib0h	459	11	the	the	DT
cord-021419-nypnib0h	459	12	polyol	polyol	NNP
cord-021419-nypnib0h	459	13	moiety	moiety	NNP
cord-021419-nypnib0h	459	14	plays	play	VBZ
cord-021419-nypnib0h	459	15	a	a	DT
cord-021419-nypnib0h	459	16	critical	critical	JJ
cord-021419-nypnib0h	459	17	role	role	NN
cord-021419-nypnib0h	459	18	in	in	IN
cord-021419-nypnib0h	459	19	antifungal	antifungal	JJ
cord-021419-nypnib0h	459	20	activity	activity	NN
cord-021419-nypnib0h	459	21	,	,	,
cord-021419-nypnib0h	459	22	although	although	IN
cord-021419-nypnib0h	459	23	this	this	DT
cord-021419-nypnib0h	459	24	group	group	NN
cord-021419-nypnib0h	459	25	has	have	VBZ
cord-021419-nypnib0h	459	26	not	not	RB
cord-021419-nypnib0h	459	27	previously	previously	RB
cord-021419-nypnib0h	459	28	been	be	VBN
cord-021419-nypnib0h	459	29	considered	consider	VBN
cord-021419-nypnib0h	459	30	of	of	IN
cord-021419-nypnib0h	459	31	importance	importance	NN
cord-021419-nypnib0h	459	32	in	in	IN
cord-021419-nypnib0h	459	33	the	the	DT
cord-021419-nypnib0h	459	34	model	model	NN
cord-021419-nypnib0h	459	35	of	of	IN
cord-021419-nypnib0h	459	36	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	459	37	binding	binding	NN
cord-021419-nypnib0h	459	38	to	to	IN
cord-021419-nypnib0h	459	39	the	the	DT
cord-021419-nypnib0h	459	40	target	target	NN
cord-021419-nypnib0h	459	41	.	.	.
cord-021419-nypnib0h	460	1	Compounds	compound	NNS
cord-021419-nypnib0h	460	2	containing	contain	VBG
cord-021419-nypnib0h	460	3	a	a	DT
cord-021419-nypnib0h	460	4	single	single	JJ
cord-021419-nypnib0h	460	5	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	460	6	group	group	NN
cord-021419-nypnib0h	460	7	at	at	IN
cord-021419-nypnib0h	460	8	the	the	DT
cord-021419-nypnib0h	460	9	7	7	CD
cord-021419-nypnib0h	460	10	position	position	NN
cord-021419-nypnib0h	460	11	of	of	IN
cord-021419-nypnib0h	460	12	C(7)7C(10	C(7)7C(10	NNP
cord-021419-nypnib0h	460	13	)	)	-RRB-
cord-021419-nypnib0h	461	1	(	(	-LRB-
cord-021419-nypnib0h	461	2	66a	66a	NN
cord-021419-nypnib0h	461	3	and	and	CC
cord-021419-nypnib0h	461	4	67	67	CD
cord-021419-nypnib0h	461	5	)	)	-RRB-
cord-021419-nypnib0h	461	6	exhibit	exhibit	VB
cord-021419-nypnib0h	461	7	low	low	JJ
cord-021419-nypnib0h	461	8	activity	activity	NN
cord-021419-nypnib0h	461	9	against	against	IN
cord-021419-nypnib0h	461	10	the	the	DT
cord-021419-nypnib0h	461	11	tested	test	VBN
cord-021419-nypnib0h	461	12	fungal	fungal	JJ
cord-021419-nypnib0h	461	13	strains	strain	NNS
cord-021419-nypnib0h	461	14	.	.	.
cord-021419-nypnib0h	462	1	Polyenes	polyene	NNS
cord-021419-nypnib0h	462	2	containing	contain	VBG
cord-021419-nypnib0h	462	3	two	two	CD
cord-021419-nypnib0h	462	4	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	462	5	groups	group	NNS
cord-021419-nypnib0h	462	6	at	at	IN
cord-021419-nypnib0h	462	7	the	the	DT
cord-021419-nypnib0h	462	8	7	7	CD
cord-021419-nypnib0h	462	9	and	and	CC
cord-021419-nypnib0h	462	10	9	9	CD
cord-021419-nypnib0h	462	11	positions	position	NNS
cord-021419-nypnib0h	462	12	(	(	-LRB-
cord-021419-nypnib0h	462	13	68a	68a	NNS
cord-021419-nypnib0h	462	14	and	and	CC
cord-021419-nypnib0h	462	15	69	69	CD
cord-021419-nypnib0h	462	16	)	)	-RRB-
cord-021419-nypnib0h	462	17	are	be	VBP
cord-021419-nypnib0h	462	18	inactive	inactive	JJ
cord-021419-nypnib0h	462	19	.	.	.
cord-021419-nypnib0h	463	1	48	48	CD
cord-021419-nypnib0h	463	2	Antibiotics	antibiotic	NNS
cord-021419-nypnib0h	463	3	and	and	CC
cord-021419-nypnib0h	463	4	semi	semi	JJ
cord-021419-nypnib0h	463	5	-	-	JJ
cord-021419-nypnib0h	463	6	synthetic	synthetic	JJ
cord-021419-nypnib0h	463	7	derivatives	derivative	NNS
cord-021419-nypnib0h	463	8	containing	contain	VBG
cord-021419-nypnib0h	463	9	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	463	10	groups	group	NNS
cord-021419-nypnib0h	463	11	at	at	IN
cord-021419-nypnib0h	463	12	the	the	DT
cord-021419-nypnib0h	463	13	8	8	CD
cord-021419-nypnib0h	463	14	and	and	CC
cord-021419-nypnib0h	463	15	9	9	CD
cord-021419-nypnib0h	463	16	positions	position	NNS
cord-021419-nypnib0h	463	17	(	(	-LRB-
cord-021419-nypnib0h	463	18	AmB	amb	NN
cord-021419-nypnib0h	463	19	,	,	,
cord-021419-nypnib0h	463	20	63a	63a	NNP
cord-021419-nypnib0h	463	21	,	,	,
cord-021419-nypnib0h	463	22	b	b	LS
cord-021419-nypnib0h	463	23	)	)	-RRB-
cord-021419-nypnib0h	463	24	and	and	CC
cord-021419-nypnib0h	463	25	at	at	IN
cord-021419-nypnib0h	463	26	the	the	DT
cord-021419-nypnib0h	463	27	C(7	C(7	NNP
cord-021419-nypnib0h	463	28	)	)	-RRB-
cord-021419-nypnib0h	463	29	and	and	CC
cord-021419-nypnib0h	463	30	C(10	C(10	NNP
cord-021419-nypnib0h	463	31	)	)	-RRB-
cord-021419-nypnib0h	463	32	atoms	atom	NNS
cord-021419-nypnib0h	463	33	[	[	-LRB-
cord-021419-nypnib0h	463	34	S44HP	s44hp	CC
cord-021419-nypnib0h	463	35	(	(	-LRB-
cord-021419-nypnib0h	463	36	64a	64a	NNS
cord-021419-nypnib0h	463	37	,	,	,
cord-021419-nypnib0h	463	38	b	b	LS
cord-021419-nypnib0h	463	39	)	)	-RRB-
cord-021419-nypnib0h	463	40	and	and	CC
cord-021419-nypnib0h	463	41	BSG005	BSG005	NNP
cord-021419-nypnib0h	463	42	(	(	-LRB-
cord-021419-nypnib0h	463	43	65a	65a	CD
cord-021419-nypnib0h	463	44	,	,	,
cord-021419-nypnib0h	463	45	b	b	LS
cord-021419-nypnib0h	463	46	)	)	-RRB-
cord-021419-nypnib0h	463	47	]	]	-RRB-
cord-021419-nypnib0h	463	48	displayed	display	VBD
cord-021419-nypnib0h	463	49	the	the	DT
cord-021419-nypnib0h	463	50	best	good	JJS
cord-021419-nypnib0h	463	51	results	result	NNS
cord-021419-nypnib0h	463	52	.	.	.
cord-021419-nypnib0h	464	1	The	the	DT
cord-021419-nypnib0h	464	2	design	design	NN
cord-021419-nypnib0h	464	3	of	of	IN
cord-021419-nypnib0h	464	4	hybrid	hybrid	JJ
cord-021419-nypnib0h	464	5	analogues	analogue	NNS
cord-021419-nypnib0h	464	6	of	of	IN
cord-021419-nypnib0h	464	7	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	464	8	containing	contain	VBG
cord-021419-nypnib0h	464	9	pharmacophore	pharmacophore	NNP
cord-021419-nypnib0h	464	10	moieties	moiety	NNS
cord-021419-nypnib0h	464	11	,	,	,
cord-021419-nypnib0h	464	12	which	which	WDT
cord-021419-nypnib0h	464	13	affect	affect	VBP
cord-021419-nypnib0h	464	14	targets	target	NNS
cord-021419-nypnib0h	464	15	different	different	JJ
cord-021419-nypnib0h	464	16	from	from	IN
cord-021419-nypnib0h	464	17	those	those	DT
cord-021419-nypnib0h	464	18	used	use	VBN
cord-021419-nypnib0h	464	19	by	by	IN
cord-021419-nypnib0h	464	20	the	the	DT
cord-021419-nypnib0h	464	21	starting	start	VBG
cord-021419-nypnib0h	464	22	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	464	23	,	,	,
cord-021419-nypnib0h	464	24	is	be	VBZ
cord-021419-nypnib0h	464	25	a	a	DT
cord-021419-nypnib0h	464	26	promising	promising	JJ
cord-021419-nypnib0h	464	27	line	line	NN
cord-021419-nypnib0h	464	28	of	of	IN
cord-021419-nypnib0h	464	29	research	research	NN
cord-021419-nypnib0h	464	30	.	.	.
cord-021419-nypnib0h	465	1	28	28	CD
cord-021419-nypnib0h	465	2	,	,	,
cord-021419-nypnib0h	465	3	29	29	CD
cord-021419-nypnib0h	466	1	Some	some	DT
cord-021419-nypnib0h	466	2	benzoxaborole	benzoxaborole	NN
cord-021419-nypnib0h	466	3	-	-	HYPH
cord-021419-nypnib0h	466	4	containing	contain	VBG
cord-021419-nypnib0h	466	5	compounds	compound	NNS
cord-021419-nypnib0h	466	6	exhibit	exhibit	VBP
cord-021419-nypnib0h	466	7	pronounced	pronounce	VBN
cord-021419-nypnib0h	466	8	antifungal	antifungal	JJ
cord-021419-nypnib0h	466	9	activity	activity	NN
cord-021419-nypnib0h	466	10	.	.	.
cord-021419-nypnib0h	467	1	51	51	CD
cord-021419-nypnib0h	467	2	Methods	method	NNS
cord-021419-nypnib0h	467	3	were	be	VBD
cord-021419-nypnib0h	467	4	developed	develop	VBN
cord-021419-nypnib0h	467	5	for	for	IN
cord-021419-nypnib0h	467	6	the	the	DT
cord-021419-nypnib0h	467	7	synthesis	synthesis	NN
cord-021419-nypnib0h	467	8	of	of	IN
cord-021419-nypnib0h	467	9	dual	dual	JJ
cord-021419-nypnib0h	467	10	-	-	HYPH
cord-021419-nypnib0h	467	11	action	action	NN
cord-021419-nypnib0h	467	12	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	467	13	based	base	VBN
cord-021419-nypnib0h	467	14	on	on	IN
cord-021419-nypnib0h	467	15	AmB	amb	NN
cord-021419-nypnib0h	467	16	(	(	-LRB-
cord-021419-nypnib0h	467	17	63a	63a	NNP
cord-021419-nypnib0h	467	18	)	)	-RRB-
cord-021419-nypnib0h	467	19	and	and	CC
cord-021419-nypnib0h	467	20	different	different	JJ
cord-021419-nypnib0h	467	21	types	type	NNS
cord-021419-nypnib0h	467	22	of	of	IN
cord-021419-nypnib0h	467	23	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	467	24	.	.	.
cord-021419-nypnib0h	468	1	The	the	DT
cord-021419-nypnib0h	468	2	following	follow	VBG
cord-021419-nypnib0h	468	3	five	five	CD
cord-021419-nypnib0h	468	4	types	type	NNS
cord-021419-nypnib0h	468	5	of	of	IN
cord-021419-nypnib0h	468	6	conjugates	conjugate	NNS
cord-021419-nypnib0h	468	7	were	be	VBD
cord-021419-nypnib0h	468	8	synthesized	synthesize	VBN
cord-021419-nypnib0h	468	9	depending	depend	VBG
cord-021419-nypnib0h	468	10	on	on	IN
cord-021419-nypnib0h	468	11	the	the	DT
cord-021419-nypnib0h	468	12	nature	nature	NN
cord-021419-nypnib0h	468	13	of	of	IN
cord-021419-nypnib0h	468	14	the	the	DT
cord-021419-nypnib0h	468	15	functional	functional	JJ
cord-021419-nypnib0h	468	16	group	group	NN
cord-021419-nypnib0h	468	17	in	in	IN
cord-021419-nypnib0h	468	18	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	468	19	,	,	,
cord-021419-nypnib0h	468	20	which	which	WDT
cord-021419-nypnib0h	468	21	can	can	MD
cord-021419-nypnib0h	468	22	be	be	VB
cord-021419-nypnib0h	468	23	used	use	VBN
cord-021419-nypnib0h	468	24	to	to	TO
cord-021419-nypnib0h	468	25	attach	attach	VB
cord-021419-nypnib0h	468	26	the	the	DT
cord-021419-nypnib0h	468	27	latter	latter	JJ
cord-021419-nypnib0h	468	28	to	to	IN
cord-021419-nypnib0h	468	29	the	the	DT
cord-021419-nypnib0h	468	30	AmB	amb	NN
cord-021419-nypnib0h	468	31	molecule	molecule	NN
cord-021419-nypnib0h	468	32	:	:	:
cord-021419-nypnib0h	468	33	C	C	NNP
cord-021419-nypnib0h	468	34	(	(	-LRB-
cord-021419-nypnib0h	468	35	16	16	CD
cord-021419-nypnib0h	468	36	)	)	-RRB-
cord-021419-nypnib0h	468	37	 	 	_SP
cord-021419-nypnib0h	468	38	3	3	CD
cord-021419-nypnib0h	468	39	H	h	NN
cord-021419-nypnib0h	468	40	-N	-n	NN
cord-021419-nypnib0h	468	41	-	-	HYPH
cord-021419-nypnib0h	468	42	sulfo	sulfo	NN
cord-021419-nypnib0h	468	43	derivative	derivative	NN
cord-021419-nypnib0h	468	44	87	87	CD
cord-021419-nypnib0h	468	45	and	and	CC
cord-021419-nypnib0h	468	46	3	3	CD
cord-021419-nypnib0h	468	47	H	h	NN
cord-021419-nypnib0h	468	48	-N	-n	NN
cord-021419-nypnib0h	468	49	-	-	HYPH
cord-021419-nypnib0h	468	50	mono	mono	NN
cord-021419-nypnib0h	468	51	-	-	:
cord-021419-nypnib0h	468	52	and	and	CC
cord-021419-nypnib0h	468	53	3	3	CD
cord-021419-nypnib0h	468	54	H	h	NN
cord-021419-nypnib0h	469	1	-N	-N	NFP
cord-021419-nypnib0h	469	2	,	,	,
cord-021419-nypnib0h	469	3	N	N	NNP
cord-021419-nypnib0h	469	4	-	-	HYPH
cord-021419-nypnib0h	469	5	dialkyl	dialkyl	NN
cord-021419-nypnib0h	469	6	derivatives	derivative	NNS
cord-021419-nypnib0h	469	7	88a	88a	NNS
cord-021419-nypnib0h	469	8	and	and	CC
cord-021419-nypnib0h	469	9	89	89	CD
cord-021419-nypnib0h	470	1	(	(	-LRB-
cord-021419-nypnib0h	470	2	Scheme	scheme	NN
cord-021419-nypnib0h	470	3	22	22	CD
cord-021419-nypnib0h	470	4	)	)	-RRB-
cord-021419-nypnib0h	470	5	.	.	.
cord-021419-nypnib0h	471	1	52	52	CD
cord-021419-nypnib0h	472	1	Amide	Amide	NNP
cord-021419-nypnib0h	472	2	83	83	CD
cord-021419-nypnib0h	472	3	was	be	VBD
cord-021419-nypnib0h	472	4	produced	produce	VBN
cord-021419-nypnib0h	472	5	by	by	IN
cord-021419-nypnib0h	472	6	the	the	DT
cord-021419-nypnib0h	472	7	standard	standard	JJ
cord-021419-nypnib0h	472	8	procedure	procedure	NN
cord-021419-nypnib0h	472	9	that	that	WDT
cord-021419-nypnib0h	472	10	was	be	VBD
cord-021419-nypnib0h	472	11	applied	apply	VBN
cord-021419-nypnib0h	472	12	to	to	TO
cord-021419-nypnib0h	472	13	prepare	prepare	VB
cord-021419-nypnib0h	472	14	the	the	DT
cord-021419-nypnib0h	472	15	above	above	RB
cord-021419-nypnib0h	472	16	-	-	HYPH
cord-021419-nypnib0h	472	17	described	describe	VBN
cord-021419-nypnib0h	472	18	amides	amide	NNS
cord-021419-nypnib0h	472	19	;	;	:
cord-021419-nypnib0h	472	20	however	however	RB
cord-021419-nypnib0h	472	21	,	,	,
cord-021419-nypnib0h	472	22	the	the	DT
cord-021419-nypnib0h	472	23	yield	yield	NN
cord-021419-nypnib0h	472	24	of	of	IN
cord-021419-nypnib0h	472	25	83	83	CD
cord-021419-nypnib0h	472	26	was	be	VBD
cord-021419-nypnib0h	472	27	low	low	JJ
cord-021419-nypnib0h	472	28	(	(	-LRB-
cord-021419-nypnib0h	472	29	10	10	CD
cord-021419-nypnib0h	472	30	%	%	NN
cord-021419-nypnib0h	472	31	)	)	-RRB-
cord-021419-nypnib0h	472	32	.	.	.
cord-021419-nypnib0h	473	1	Apparently	apparently	RB
cord-021419-nypnib0h	473	2	,	,	,
cord-021419-nypnib0h	473	3	the	the	DT
cord-021419-nypnib0h	473	4	amidation	amidation	NN
cord-021419-nypnib0h	473	5	interferes	interfere	VBZ
cord-021419-nypnib0h	473	6	with	with	IN
cord-021419-nypnib0h	473	7	the	the	DT
cord-021419-nypnib0h	473	8	formation	formation	NN
cord-021419-nypnib0h	473	9	of	of	IN
cord-021419-nypnib0h	473	10	the	the	DT
cord-021419-nypnib0h	473	11	aminoborole	aminoborole	NNP
cord-021419-nypnib0h	473	12	complex	complex	NN
cord-021419-nypnib0h	473	13	with	with	IN
cord-021419-nypnib0h	473	14	AmB.	AmB.	NNP
cord-021419-nypnib0h	474	1	As	as	IN
cord-021419-nypnib0h	474	2	mentioned	mention	VBN
cord-021419-nypnib0h	474	3	above	above	RB
cord-021419-nypnib0h	474	4	,	,	,
cord-021419-nypnib0h	474	5	the	the	DT
cord-021419-nypnib0h	474	6	yields	yield	NNS
cord-021419-nypnib0h	474	7	of	of	IN
cord-021419-nypnib0h	474	8	AmB	amb	NN
cord-021419-nypnib0h	474	9	carboxamides	carboxamide	NNS
cord-021419-nypnib0h	474	10	in	in	IN
cord-021419-nypnib0h	474	11	this	this	DT
cord-021419-nypnib0h	474	12	reaction	reaction	NN
cord-021419-nypnib0h	474	13	using	use	VBG
cord-021419-nypnib0h	474	14	other	other	JJ
cord-021419-nypnib0h	474	15	amines	amine	NNS
cord-021419-nypnib0h	474	16	are	be	VBP
cord-021419-nypnib0h	474	17	higher	high	JJR
cord-021419-nypnib0h	474	18	than	than	IN
cord-021419-nypnib0h	474	19	50	50	CD
cord-021419-nypnib0h	474	20	%	%	NN
cord-021419-nypnib0h	474	21	.	.	.
cord-021419-nypnib0h	475	1	3	3	CD
cord-021419-nypnib0h	475	2	H	h	NN
cord-021419-nypnib0h	475	3	-N	-N	.
cord-021419-nypnib0h	476	1	-Derivatives	-derivative	NNS
cord-021419-nypnib0h	476	2	84a	84a	NNS
cord-021419-nypnib0h	476	3	±	±	NNP
cord-021419-nypnib0h	476	4	86a	86a	NNS
cord-021419-nypnib0h	476	5	were	be	VBD
cord-021419-nypnib0h	476	6	prepared	prepare	VBN
cord-021419-nypnib0h	476	7	from	from	IN
cord-021419-nypnib0h	476	8	AmB	amb	NN
cord-021419-nypnib0h	476	9	(	(	-LRB-
cord-021419-nypnib0h	476	10	63a	63a	NN
cord-021419-nypnib0h	476	11	)	)	-RRB-
cord-021419-nypnib0h	476	12	using	use	VBG
cord-021419-nypnib0h	476	13	in	in	IN
cord-021419-nypnib0h	476	14	situ	situ	NN
cord-021419-nypnib0h	476	15	generated	generate	VBN
cord-021419-nypnib0h	476	16	OSu	osu	NN
cord-021419-nypnib0h	476	17	-	-	HYPH
cord-021419-nypnib0h	476	18	activated	activate	VBN
cord-021419-nypnib0h	476	19	esters	ester	NNS
cord-021419-nypnib0h	476	20	.	.	.
cord-021419-nypnib0h	477	1	3	3	CD
cord-021419-nypnib0h	477	2	H	h	NN
cord-021419-nypnib0h	477	3	-N	-n	NN
cord-021419-nypnib0h	477	4	-	-	:
cord-021419-nypnib0h	477	5	Sulfo	Sulfo	NNP
cord-021419-nypnib0h	477	6	derivative	derivative	NN
cord-021419-nypnib0h	477	7	87	87	CD
cord-021419-nypnib0h	477	8	was	be	VBD
cord-021419-nypnib0h	477	9	synthesized	synthesize	VBN
cord-021419-nypnib0h	477	10	by	by	IN
cord-021419-nypnib0h	477	11	the	the	DT
cord-021419-nypnib0h	477	12	reaction	reaction	NN
cord-021419-nypnib0h	477	13	of	of	IN
cord-021419-nypnib0h	477	14	63a	63a	PRP
cord-021419-nypnib0h	477	15	with	with	IN
cord-021419-nypnib0h	477	16	the	the	DT
cord-021419-nypnib0h	477	17	appropriate	appropriate	JJ
cord-021419-nypnib0h	477	18	sulfochloride	sulfochloride	NN
cord-021419-nypnib0h	477	19	in	in	IN
cord-021419-nypnib0h	477	20	the	the	DT
cord-021419-nypnib0h	477	21	presence	presence	NN
cord-021419-nypnib0h	477	22	of	of	IN
cord-021419-nypnib0h	477	23	pyridine	pyridine	NN
cord-021419-nypnib0h	477	24	(	(	-LRB-
cord-021419-nypnib0h	477	25	Py	py	NN
cord-021419-nypnib0h	477	26	)	)	-RRB-
cord-021419-nypnib0h	477	27	;	;	:
cord-021419-nypnib0h	477	28	3	3	CD
cord-021419-nypnib0h	477	29	H	h	NN
cord-021419-nypnib0h	477	30	-N	-n	NN
cord-021419-nypnib0h	477	31	-	-	HYPH
cord-021419-nypnib0h	477	32	alkyl	alkyl	JJ
cord-021419-nypnib0h	477	33	analogues	analogue	NNS
cord-021419-nypnib0h	477	34	88a	88a	NNS
cord-021419-nypnib0h	477	35	and	and	CC
cord-021419-nypnib0h	477	36	89	89	CD
cord-021419-nypnib0h	477	37	were	be	VBD
cord-021419-nypnib0h	477	38	prepared	prepare	VBN
cord-021419-nypnib0h	477	39	by	by	IN
cord-021419-nypnib0h	477	40	the	the	DT
cord-021419-nypnib0h	477	41	reaction	reaction	NN
cord-021419-nypnib0h	477	42	of	of	IN
cord-021419-nypnib0h	477	43	63a	63a	PRP
cord-021419-nypnib0h	477	44	with	with	IN
cord-021419-nypnib0h	477	45	the	the	DT
cord-021419-nypnib0h	477	46	appropriate	appropriate	JJ
cord-021419-nypnib0h	477	47	aldehyde	aldehyde	NN
cord-021419-nypnib0h	477	48	in	in	IN
cord-021419-nypnib0h	477	49	the	the	DT
cord-021419-nypnib0h	477	50	presence	presence	NN
cord-021419-nypnib0h	477	51	of	of	IN
cord-021419-nypnib0h	477	52	NaBH	NaBH	NNP
cord-021419-nypnib0h	477	53	3	3	CD
cord-021419-nypnib0h	477	54	CN	CN	NNP
cord-021419-nypnib0h	477	55	.	.	.
cord-021419-nypnib0h	478	1	52	52	CD
cord-021419-nypnib0h	479	1	The	the	DT
cord-021419-nypnib0h	479	2	amidation	amidation	NN
cord-021419-nypnib0h	479	3	of	of	IN
cord-021419-nypnib0h	479	4	derivatives	derivative	NNS
cord-021419-nypnib0h	479	5	84a	84a	NNS
cord-021419-nypnib0h	479	6	and	and	CC
cord-021419-nypnib0h	479	7	87a	87a	NNS
cord-021419-nypnib0h	479	8	with	with	IN
cord-021419-nypnib0h	479	9	N	n	CD
cord-021419-nypnib0h	479	10	,	,	,
cord-021419-nypnib0h	479	11	N	N	NNP
cord-021419-nypnib0h	479	12	-	-	HYPH
cord-021419-nypnib0h	479	13	dimethylethylenediamine	dimethylethylenediamine	NN
cord-021419-nypnib0h	479	14	in	in	IN
cord-021419-nypnib0h	479	15	the	the	DT
cord-021419-nypnib0h	479	16	presence	presence	NN
cord-021419-nypnib0h	479	17	of	of	IN
cord-021419-nypnib0h	479	18	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	479	19	gave	give	VBD
cord-021419-nypnib0h	479	20	84b	84b	NNS
cord-021419-nypnib0h	479	21	and	and	CC
cord-021419-nypnib0h	479	22	87b	87b	NNS
cord-021419-nypnib0h	479	23	,	,	,
cord-021419-nypnib0h	479	24	respectively	respectively	RB
cord-021419-nypnib0h	479	25	(	(	-LRB-
cord-021419-nypnib0h	479	26	Scheme	scheme	NN
cord-021419-nypnib0h	479	27	23	23	CD
cord-021419-nypnib0h	479	28	)	)	-RRB-
cord-021419-nypnib0h	479	29	.	.	.
cord-021419-nypnib0h	480	1	An	an	DT
cord-021419-nypnib0h	480	2	attempt	attempt	NN
cord-021419-nypnib0h	480	3	to	to	TO
cord-021419-nypnib0h	480	4	synthesize	synthesize	VB
cord-021419-nypnib0h	480	5	disubstituted	disubstituted	JJ
cord-021419-nypnib0h	480	6	3	3	CD
cord-021419-nypnib0h	480	7	H	h	NN
cord-021419-nypnib0h	480	8	-N	-n	NN
cord-021419-nypnib0h	480	9	-	-	HYPH
cord-021419-nypnib0h	480	10	alkyl	alkyl	NN
cord-021419-nypnib0h	480	11	-	-	HYPH
cord-021419-nypnib0h	480	12	DMAE	dmae	NN
cord-021419-nypnib0h	480	13	analogue	analogue	NN
cord-021419-nypnib0h	480	14	88b	88b	NNS
cord-021419-nypnib0h	480	15	according	accord	VBG
cord-021419-nypnib0h	480	16	to	to	IN
cord-021419-nypnib0h	480	17	a	a	DT
cord-021419-nypnib0h	480	18	similar	similar	JJ
cord-021419-nypnib0h	480	19	scheme	scheme	NN
cord-021419-nypnib0h	480	20	from	from	IN
cord-021419-nypnib0h	480	21	3	3	CD
cord-021419-nypnib0h	480	22	H	h	NN
cord-021419-nypnib0h	480	23	-N	-n	NN
cord-021419-nypnib0h	480	24	-	-	HYPH
cord-021419-nypnib0h	480	25	alkylamino	alkylamino	NN
cord-021419-nypnib0h	480	26	derivative	derivative	JJ
cord-021419-nypnib0h	480	27	88a	88a	NNS
cord-021419-nypnib0h	480	28	failed	fail	VBD
cord-021419-nypnib0h	480	29	(	(	-LRB-
cord-021419-nypnib0h	480	30	see	see	VB
cord-021419-nypnib0h	480	31	Scheme	Scheme	NNP
cord-021419-nypnib0h	480	32	22	22	CD
cord-021419-nypnib0h	480	33	)	)	-RRB-
cord-021419-nypnib0h	480	34	.	.	.
cord-021419-nypnib0h	481	1	50	50	CD
cord-021419-nypnib0h	482	1	Nevertheless	nevertheless	RB
cord-021419-nypnib0h	482	2	,	,	,
cord-021419-nypnib0h	482	3	compound	compound	NN
cord-021419-nypnib0h	482	4	88b	88b	NNS
cord-021419-nypnib0h	482	5	was	be	VBD
cord-021419-nypnib0h	482	6	prepared	prepare	VBN
cord-021419-nypnib0h	482	7	using	use	VBG
cord-021419-nypnib0h	482	8	an	an	DT
cord-021419-nypnib0h	482	9	alternative	alternative	JJ
cord-021419-nypnib0h	482	10	approach	approach	NN
cord-021419-nypnib0h	482	11	by	by	IN
cord-021419-nypnib0h	482	12	the	the	DT
cord-021419-nypnib0h	482	13	alkylation	alkylation	NN
cord-021419-nypnib0h	482	14	of	of	IN
cord-021419-nypnib0h	482	15	C(16)-amide	c(16)-amide	NN
cord-021419-nypnib0h	482	16	derivative	derivative	JJ
cord-021419-nypnib0h	482	17	63b	63b	NNS
cord-021419-nypnib0h	483	1	with	with	IN
cord-021419-nypnib0h	483	2	1-hydroxy-1,3-dihydrobenzo[c	1-hydroxy-1,3-dihydrobenzo[c	CD
cord-021419-nypnib0h	483	3	]	]	-RRB-
cord-021419-nypnib0h	484	1	[	[	-LRB-
cord-021419-nypnib0h	484	2	1	1	CD
cord-021419-nypnib0h	484	3	,	,	,
cord-021419-nypnib0h	484	4	2	2	CD
cord-021419-nypnib0h	484	5	]	]	-RRB-
cord-021419-nypnib0h	484	6	oxaborole-6-carbaldehyde	oxaborole-6-carbaldehyde	NNP
cord-021419-nypnib0h	484	7	in	in	IN
cord-021419-nypnib0h	484	8	the	the	DT
cord-021419-nypnib0h	484	9	presence	presence	NN
cord-021419-nypnib0h	484	10	of	of	IN
cord-021419-nypnib0h	484	11	NaBH	NaBH	NNP
cord-021419-nypnib0h	484	12	3	3	CD
cord-021419-nypnib0h	484	13	CN	CN	NNP
cord-021419-nypnib0h	484	14	(	(	-LRB-
cord-021419-nypnib0h	484	15	see	see	VB
cord-021419-nypnib0h	484	16	Scheme	Scheme	NNP
cord-021419-nypnib0h	484	17	23	23	CD
cord-021419-nypnib0h	484	18	)	)	-RRB-
cord-021419-nypnib0h	484	19	.	.	.
cord-021419-nypnib0h	485	1	52	52	CD
cord-021419-nypnib0h	486	1	Tandem	tandem	JJ
cord-021419-nypnib0h	486	2	mass	mass	NN
cord-021419-nypnib0h	486	3	spectrometry	spectrometry	NN
cord-021419-nypnib0h	486	4	(	(	-LRB-
cord-021419-nypnib0h	486	5	ESI	ESI	NNP
cord-021419-nypnib0h	486	6	-	-	HYPH
cord-021419-nypnib0h	486	7	MS	MS	NNP
cord-021419-nypnib0h	486	8	/	/	SYM
cord-021419-nypnib0h	486	9	MS	MS	NNP
cord-021419-nypnib0h	486	10	-	-	HYPH
cord-021419-nypnib0h	486	11	MRM	MRM	NNP
cord-021419-nypnib0h	486	12	)	)	-RRB-
cord-021419-nypnib0h	486	13	studies	study	NNS
cord-021419-nypnib0h	486	14	showed	show	VBD
cord-021419-nypnib0h	486	15	that	that	IN
cord-021419-nypnib0h	486	16	different	different	JJ
cord-021419-nypnib0h	486	17	fragmentation	fragmentation	NN
cord-021419-nypnib0h	486	18	patterns	pattern	NNS
cord-021419-nypnib0h	486	19	are	be	VBP
cord-021419-nypnib0h	486	20	possible	possible	JJ
cord-021419-nypnib0h	486	21	depending	depend	VBG
cord-021419-nypnib0h	486	22	on	on	IN
cord-021419-nypnib0h	486	23	the	the	DT
cord-021419-nypnib0h	486	24	modification	modification	NN
cord-021419-nypnib0h	486	25	of	of	IN
cord-021419-nypnib0h	486	26	the	the	DT
cord-021419-nypnib0h	486	27	starting	starting	NN
cord-021419-nypnib0h	486	28	polyene	polyene	NN
cord-021419-nypnib0h	486	29	(	(	-LRB-
cord-021419-nypnib0h	486	30	Scheme	scheme	NN
cord-021419-nypnib0h	486	31	24	24	CD
cord-021419-nypnib0h	486	32	)	)	-RRB-
cord-021419-nypnib0h	486	33	.	.	.
cord-021419-nypnib0h	487	1	52	52	CD
cord-021419-nypnib0h	488	1	In	in	IN
cord-021419-nypnib0h	488	2	many	many	JJ
cord-021419-nypnib0h	488	3	cases	case	NNS
cord-021419-nypnib0h	488	4	,	,	,
cord-021419-nypnib0h	488	5	the	the	DT
cord-021419-nypnib0h	488	6	introduction	introduction	NN
cord-021419-nypnib0h	488	7	of	of	IN
cord-021419-nypnib0h	488	8	the	the	DT
cord-021419-nypnib0h	488	9	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	488	10	substituent	substituent	VBZ
cord-021419-nypnib0h	488	11	leads	lead	VBZ
cord-021419-nypnib0h	488	12	to	to	IN
cord-021419-nypnib0h	488	13	a	a	DT
cord-021419-nypnib0h	488	14	decrease	decrease	NN
cord-021419-nypnib0h	488	15	in	in	IN
cord-021419-nypnib0h	488	16	cytotoxicity	cytotoxicity	NN
cord-021419-nypnib0h	488	17	and	and	CC
cord-021419-nypnib0h	488	18	haemolytic	haemolytic	JJ
cord-021419-nypnib0h	488	19	activity	activity	NN
cord-021419-nypnib0h	488	20	with	with	IN
cord-021419-nypnib0h	488	21	retention	retention	NN
cord-021419-nypnib0h	488	22	of	of	IN
cord-021419-nypnib0h	488	23	high	high	JJ
cord-021419-nypnib0h	488	24	antifungal	antifungal	JJ
cord-021419-nypnib0h	488	25	activity	activity	NN
cord-021419-nypnib0h	488	26	.	.	.
cord-021419-nypnib0h	489	1	These	these	DT
cord-021419-nypnib0h	489	2	facts	fact	NNS
cord-021419-nypnib0h	489	3	were	be	VBD
cord-021419-nypnib0h	489	4	confirmed	confirm	VBN
cord-021419-nypnib0h	489	5	by	by	IN
cord-021419-nypnib0h	489	6	membrane	membrane	NN
cord-021419-nypnib0h	489	7	activity	activity	NN
cord-021419-nypnib0h	489	8	assays	assay	NNS
cord-021419-nypnib0h	489	9	.	.	.
cord-021419-nypnib0h	490	1	53	53	CD
cord-021419-nypnib0h	491	1	The	the	DT
cord-021419-nypnib0h	491	2	results	result	NNS
cord-021419-nypnib0h	491	3	are	be	VBP
cord-021419-nypnib0h	491	4	given	give	VBN
cord-021419-nypnib0h	491	5	in	in	IN
cord-021419-nypnib0h	491	6	Table	Table	NNP
cord-021419-nypnib0h	491	7	1	1	CD
cord-021419-nypnib0h	491	8	.	.	.
cord-021419-nypnib0h	492	1	Semi	semi	JJ
cord-021419-nypnib0h	492	2	-	-	JJ
cord-021419-nypnib0h	492	3	synthetic	synthetic	JJ
cord-021419-nypnib0h	492	4	AmB	amb	NN
cord-021419-nypnib0h	492	5	derivatives	derivative	NNS
cord-021419-nypnib0h	492	6	63b	63b	NNS
cord-021419-nypnib0h	492	7	,	,	,
cord-021419-nypnib0h	493	1	d	d	NNP
cord-021419-nypnib0h	493	2	,	,	,
cord-021419-nypnib0h	493	3	e	e	NNP
cord-021419-nypnib0h	493	4	,	,	,
cord-021419-nypnib0h	493	5	84a	84a	NNS
cord-021419-nypnib0h	493	6	,	,	,
cord-021419-nypnib0h	493	7	b	b	NN
cord-021419-nypnib0h	493	8	,	,	,
cord-021419-nypnib0h	493	9	85a	85a	NNS
cord-021419-nypnib0h	493	10	,	,	,
cord-021419-nypnib0h	493	11	87b	87b	NNS
cord-021419-nypnib0h	493	12	and	and	CC
cord-021419-nypnib0h	493	13	88a	88a	NNS
cord-021419-nypnib0h	493	14	,	,	,
cord-021419-nypnib0h	493	15	b	b	LS
cord-021419-nypnib0h	493	16	were	be	VBD
cord-021419-nypnib0h	493	17	shown	show	VBN
cord-021419-nypnib0h	493	18	to	to	TO
cord-021419-nypnib0h	493	19	have	have	VB
cord-021419-nypnib0h	493	20	a	a	DT
cord-021419-nypnib0h	493	21	significant	significant	JJ
cord-021419-nypnib0h	493	22	pore	pore	NN
cord-021419-nypnib0h	493	23	-	-	HYPH
cord-021419-nypnib0h	493	24	forming	form	VBG
cord-021419-nypnib0h	493	25	ability	ability	NN
cord-021419-nypnib0h	493	26	in	in	IN
cord-021419-nypnib0h	493	27	artificially	artificially	RB
cord-021419-nypnib0h	493	28	formed	form	VBN
cord-021419-nypnib0h	493	29	sterol	sterol	NN
cord-021419-nypnib0h	493	30	-	-	HYPH
cord-021419-nypnib0h	493	31	containing	contain	VBG
cord-021419-nypnib0h	493	32	membranes	membrane	NNS
cord-021419-nypnib0h	493	33	.	.	.
cord-021419-nypnib0h	494	1	53	53	CD
cord-021419-nypnib0h	494	2	Compounds	compound	NNS
cord-021419-nypnib0h	494	3	with	with	IN
cord-021419-nypnib0h	494	4	high	high	JJ
cord-021419-nypnib0h	494	5	antifungal	antifungal	JJ
cord-021419-nypnib0h	494	6	activity	activity	NN
cord-021419-nypnib0h	494	7	and	and	CC
cord-021419-nypnib0h	494	8	low	low	JJ
cord-021419-nypnib0h	494	9	haemolysis	haemolysis	NN
cord-021419-nypnib0h	494	10	have	have	VBP
cord-021419-nypnib0h	494	11	higher	high	JJR
cord-021419-nypnib0h	494	12	selectivity	selectivity	NN
cord-021419-nypnib0h	494	13	for	for	IN
cord-021419-nypnib0h	494	14	ergosterol	ergosterol	NN
cord-021419-nypnib0h	494	15	-	-	HYPH
cord-021419-nypnib0h	494	16	containing	contain	VBG
cord-021419-nypnib0h	494	17	fungal	fungal	JJ
cord-021419-nypnib0h	494	18	membranes	membrane	NNS
cord-021419-nypnib0h	494	19	(	(	-LRB-
cord-021419-nypnib0h	494	20	C	C	NNP
cord-021419-nypnib0h	494	21	Chol	Chol	NNP
cord-021419-nypnib0h	494	22	/C	/c	NN
cord-021419-nypnib0h	494	23	Erg	Erg	NNP
cord-021419-nypnib0h	494	24	)	)	-RRB-
cord-021419-nypnib0h	494	25	versus	versus	IN
cord-021419-nypnib0h	494	26	cholesterol	cholesterol	NN
cord-021419-nypnib0h	494	27	-	-	HYPH
cord-021419-nypnib0h	494	28	containing	contain	VBG
cord-021419-nypnib0h	494	29	human	human	JJ
cord-021419-nypnib0h	494	30	cell	cell	NN
cord-021419-nypnib0h	494	31	membranes	membrane	NNS
cord-021419-nypnib0h	494	32	compared	compare	VBN
cord-021419-nypnib0h	494	33	to	to	IN
cord-021419-nypnib0h	494	34	compound	compound	NN
cord-021419-nypnib0h	494	35	63a	63a	NNS
cord-021419-nypnib0h	494	36	.	.	.
cord-021419-nypnib0h	495	1	For	for	IN
cord-021419-nypnib0h	495	2	example	example	NN
cord-021419-nypnib0h	495	3	,	,	,
cord-021419-nypnib0h	495	4	the	the	DT
cord-021419-nypnib0h	495	5	high	high	JJ
cord-021419-nypnib0h	495	6	selectivity	selectivity	NN
cord-021419-nypnib0h	495	7	(	(	-LRB-
cord-021419-nypnib0h	495	8	5.4	5.4	CD
cord-021419-nypnib0h	495	9	AE	AE	NNP
cord-021419-nypnib0h	495	10	1.0	1.0	CD
cord-021419-nypnib0h	495	11	)	)	-RRB-
cord-021419-nypnib0h	495	12	of	of	IN
cord-021419-nypnib0h	495	13	compound	compound	NN
cord-021419-nypnib0h	495	14	84b	84b	NNS
cord-021419-nypnib0h	495	15	correlates	correlate	VBZ
cord-021419-nypnib0h	495	16	with	with	IN
cord-021419-nypnib0h	495	17	low	low	JJ
cord-021419-nypnib0h	495	18	haemolysis	haemolysis	NN
cord-021419-nypnib0h	495	19	of	of	IN
cord-021419-nypnib0h	495	20	human	human	JJ
cord-021419-nypnib0h	495	21	erythrocytes	erythrocyte	NNS
cord-021419-nypnib0h	495	22	(	(	-LRB-
cord-021419-nypnib0h	495	23	6	6	CD
cord-021419-nypnib0h	495	24	%	%	NN
cord-021419-nypnib0h	495	25	)	)	-RRB-
cord-021419-nypnib0h	495	26	.	.	.
cord-021419-nypnib0h	496	1	On	on	IN
cord-021419-nypnib0h	496	2	the	the	DT
cord-021419-nypnib0h	496	3	contrary	contrary	NN
cord-021419-nypnib0h	496	4	,	,	,
cord-021419-nypnib0h	496	5	high	high	JJ
cord-021419-nypnib0h	496	6	haemolysis	haemolysis	NN
cord-021419-nypnib0h	496	7	(	(	-LRB-
cord-021419-nypnib0h	496	8	47	47	CD
cord-021419-nypnib0h	496	9	%	%	NN
cord-021419-nypnib0h	496	10	)	)	-RRB-
cord-021419-nypnib0h	496	11	is	be	VBZ
cord-021419-nypnib0h	496	12	determined	determine	VBN
cord-021419-nypnib0h	496	13	by	by	IN
cord-021419-nypnib0h	496	14	low	low	JJ
cord-021419-nypnib0h	496	15	or	or	CC
cord-021419-nypnib0h	496	16	even	even	RB
cord-021419-nypnib0h	496	17	reverse	reverse	VB
cord-021419-nypnib0h	496	18	selectivity	selectivity	NN
cord-021419-nypnib0h	496	19	(	(	-LRB-
cord-021419-nypnib0h	496	20	C	C	NNP
cord-021419-nypnib0h	496	21	Chol	Chol	NNP
cord-021419-nypnib0h	496	22	/C	/c	NN
cord-021419-nypnib0h	496	23	Erg	Erg	NNP
cord-021419-nypnib0h	496	24	=	=	VBZ
cord-021419-nypnib0h	496	25	0.5	0.5	CD
cord-021419-nypnib0h	496	26	AE	AE	NNP
cord-021419-nypnib0h	496	27	0.2	0.2	CD
cord-021419-nypnib0h	496	28	)	)	-RRB-
cord-021419-nypnib0h	496	29	.	.	.
cord-021419-nypnib0h	497	1	For	for	IN
cord-021419-nypnib0h	497	2	AmB	amb	NN
cord-021419-nypnib0h	497	3	(	(	-LRB-
cord-021419-nypnib0h	497	4	63a	63a	NNP
cord-021419-nypnib0h	497	5	)	)	-RRB-
cord-021419-nypnib0h	497	6	and	and	CC
cord-021419-nypnib0h	497	7	its	-PRON-	PRP$
cord-021419-nypnib0h	497	8	derivative	derivative	JJ
cord-021419-nypnib0h	497	9	63b	63b	NNS
cord-021419-nypnib0h	497	10	,	,	,
cord-021419-nypnib0h	497	11	the	the	DT
cord-021419-nypnib0h	497	12	corresponding	correspond	VBG
cord-021419-nypnib0h	497	13	parameters	parameter	NNS
cord-021419-nypnib0h	497	14	have	have	VBP
cord-021419-nypnib0h	497	15	intermediate	intermediate	JJ
cord-021419-nypnib0h	497	16	values	value	NNS
cord-021419-nypnib0h	497	17	(	(	-LRB-
cord-021419-nypnib0h	497	18	C	C	NNP
cord-021419-nypnib0h	497	19	chol	chol	NNP
cord-021419-nypnib0h	497	20	/C	/c	NN
cord-021419-nypnib0h	497	21	Erg	Erg	NNP
cord-021419-nypnib0h	497	22	=	=	SYM
cord-021419-nypnib0h	497	23	2.3	2.3	CD
cord-021419-nypnib0h	497	24	±	±	NNP
cord-021419-nypnib0h	497	25	2.4	2.4	CD
cord-021419-nypnib0h	497	26	,	,	,
cord-021419-nypnib0h	497	27	haemolysis	haemolysis	NN
cord-021419-nypnib0h	497	28	15	15	CD
cord-021419-nypnib0h	497	29	%	%	NN
cord-021419-nypnib0h	497	30	±	±	NNP
cord-021419-nypnib0h	497	31	23	23	CD
cord-021419-nypnib0h	497	32	%	%	NN
cord-021419-nypnib0h	497	33	)	)	-RRB-
cord-021419-nypnib0h	497	34	.	.	.
cord-021419-nypnib0h	498	1	53	53	CD
cord-021419-nypnib0h	499	1	Amphotericin	Amphotericin	NNP
cord-021419-nypnib0h	499	2	B	B	NNP
cord-021419-nypnib0h	499	3	(	(	-LRB-
cord-021419-nypnib0h	499	4	63a	63a	NNP
cord-021419-nypnib0h	499	5	)	)	-RRB-
cord-021419-nypnib0h	499	6	was	be	VBD
cord-021419-nypnib0h	499	7	selectively	selectively	RB
cord-021419-nypnib0h	499	8	modified	modify	VBN
cord-021419-nypnib0h	499	9	at	at	IN
cord-021419-nypnib0h	499	10	the	the	DT
cord-021419-nypnib0h	499	11	mycosamine	mycosamine	JJ
cord-021419-nypnib0h	499	12	3	3	CD
cord-021419-nypnib0h	499	13	H	H	NNP
cord-021419-nypnib0h	499	14	-amino	-amino	HYPH
cord-021419-nypnib0h	499	15	group	group	NN
cord-021419-nypnib0h	499	16	or	or	CC
cord-021419-nypnib0h	499	17	the	the	DT
cord-021419-nypnib0h	499	18	C(16	C(16	NNP
cord-021419-nypnib0h	499	19	)	)	-RRB-
cord-021419-nypnib0h	499	20	carboxyl	carboxyl	NN
cord-021419-nypnib0h	499	21	group	group	NN
cord-021419-nypnib0h	499	22	.	.	.
cord-021419-nypnib0h	500	1	The	the	DT
cord-021419-nypnib0h	500	2	developed	develop	VBN
cord-021419-nypnib0h	500	3	approaches	approach	NNS
cord-021419-nypnib0h	500	4	were	be	VBD
cord-021419-nypnib0h	500	5	extended	extend	VBN
cord-021419-nypnib0h	500	6	to	to	IN
cord-021419-nypnib0h	500	7	the	the	DT
cord-021419-nypnib0h	500	8	related	related	JJ
cord-021419-nypnib0h	500	9	polyenes	polyene	NNS
cord-021419-nypnib0h	500	10	S44HP	s44hp	IN
cord-021419-nypnib0h	500	11	(	(	-LRB-
cord-021419-nypnib0h	500	12	64a	64a	NN
cord-021419-nypnib0h	500	13	)	)	-RRB-
cord-021419-nypnib0h	500	14	,	,	,
cord-021419-nypnib0h	500	15	BSG005	BSG005	NNP
cord-021419-nypnib0h	500	16	(	(	-LRB-
cord-021419-nypnib0h	500	17	65	65	CD
cord-021419-nypnib0h	500	18	)	)	-RRB-
cord-021419-nypnib0h	500	19	and	and	CC
cord-021419-nypnib0h	500	20	other	other	JJ
cord-021419-nypnib0h	500	21	genetically	genetically	RB
cord-021419-nypnib0h	500	22	engineered	engineer	VBN
cord-021419-nypnib0h	500	23	polyenes	polyene	NNS
cord-021419-nypnib0h	500	24	,	,	,
cord-021419-nypnib0h	500	25	which	which	WDT
cord-021419-nypnib0h	500	26	differ	differ	VBP
cord-021419-nypnib0h	500	27	from	from	IN
cord-021419-nypnib0h	500	28	the	the	DT
cord-021419-nypnib0h	500	29	starting	start	VBG
cord-021419-nypnib0h	500	30	AmB	amb	NN
cord-021419-nypnib0h	500	31	by	by	IN
cord-021419-nypnib0h	500	32	the	the	DT
cord-021419-nypnib0h	500	33	substituent	substituent	NN
cord-021419-nypnib0h	500	34	at	at	IN
cord-021419-nypnib0h	500	35	the	the	DT
cord-021419-nypnib0h	500	36	C(16	C(16	NNP
cord-021419-nypnib0h	500	37	)	)	-RRB-
cord-021419-nypnib0h	500	38	atom	atom	NN
cord-021419-nypnib0h	500	39	and	and	CC
cord-021419-nypnib0h	500	40	the	the	DT
cord-021419-nypnib0h	500	41	positions	position	NNS
cord-021419-nypnib0h	500	42	of	of	IN
cord-021419-nypnib0h	500	43	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	500	44	groups	group	NNS
cord-021419-nypnib0h	500	45	at	at	IN
cord-021419-nypnib0h	500	46	C(7	C(7	NNP
cord-021419-nypnib0h	500	47	)	)	-RRB-
cord-021419-nypnib0h	500	48	±	±	NNP
cord-021419-nypnib0h	500	49	C(10	C(10	NNP
cord-021419-nypnib0h	500	50	)	)	-RRB-
cord-021419-nypnib0h	500	51	of	of	IN
cord-021419-nypnib0h	500	52	the	the	DT
cord-021419-nypnib0h	500	53	aglycone	aglycone	NNP
cord-021419-nypnib0h	500	54	moiety	moiety	NN
cord-021419-nypnib0h	500	55	.	.	.
cord-021419-nypnib0h	501	1	The	the	DT
cord-021419-nypnib0h	501	2	structure	structure	NN
cord-021419-nypnib0h	501	3	±	±	CD
cord-021419-nypnib0h	501	4	activity	activity	NN
cord-021419-nypnib0h	501	5	relationship	relationship	NN
cord-021419-nypnib0h	501	6	analysis	analysis	NN
cord-021419-nypnib0h	501	7	of	of	IN
cord-021419-nypnib0h	501	8	new	new	JJ
cord-021419-nypnib0h	501	9	semisynthetic	semisynthetic	JJ
cord-021419-nypnib0h	501	10	derivatives	derivative	NNS
cord-021419-nypnib0h	501	11	of	of	IN
cord-021419-nypnib0h	501	12	polyene	polyene	NNP
cord-021419-nypnib0h	501	13	macrocycles	macrocycles	NNP
cord-021419-nypnib0h	501	14	revealed	reveal	VBD
cord-021419-nypnib0h	501	15	several	several	JJ
cord-021419-nypnib0h	501	16	general	general	JJ
cord-021419-nypnib0h	501	17	features	feature	NNS
cord-021419-nypnib0h	501	18	of	of	IN
cord-021419-nypnib0h	501	19	antifungal	antifungal	JJ
cord-021419-nypnib0h	501	20	activity	activity	NN
cord-021419-nypnib0h	501	21	.	.	.
cord-021419-nypnib0h	502	1	In	in	IN
cord-021419-nypnib0h	502	2	particular	particular	JJ
cord-021419-nypnib0h	502	3	,	,	,
cord-021419-nypnib0h	502	4	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	502	5	and	and	CC
cord-021419-nypnib0h	502	6	,	,	,
cord-021419-nypnib0h	502	7	consequently	consequently	RB
cord-021419-nypnib0h	502	8	,	,	,
cord-021419-nypnib0h	502	9	their	-PRON-	PRP$
cord-021419-nypnib0h	502	10	semi	semi	JJ
cord-021419-nypnib0h	502	11	-	-	JJ
cord-021419-nypnib0h	502	12	synthetic	synthetic	JJ
cord-021419-nypnib0h	502	13	analogues	analogue	NNS
cord-021419-nypnib0h	502	14	containing	contain	VBG
cord-021419-nypnib0h	502	15	two	two	CD
cord-021419-nypnib0h	502	16	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	502	17	groups	group	NNS
cord-021419-nypnib0h	502	18	in	in	IN
cord-021419-nypnib0h	502	19	this	this	DT
cord-021419-nypnib0h	502	20	region	region	NN
cord-021419-nypnib0h	502	21	at	at	IN
cord-021419-nypnib0h	502	22	the	the	DT
cord-021419-nypnib0h	502	23	8	8	CD
cord-021419-nypnib0h	502	24	and	and	CC
cord-021419-nypnib0h	502	25	9	9	CD
cord-021419-nypnib0h	502	26	positions	position	NNS
cord-021419-nypnib0h	502	27	(	(	-LRB-
cord-021419-nypnib0h	502	28	AmB	amb	NN
cord-021419-nypnib0h	502	29	,	,	,
cord-021419-nypnib0h	502	30	63a	63a	NNP
cord-021419-nypnib0h	502	31	)	)	-RRB-
cord-021419-nypnib0h	502	32	or	or	CC
cord-021419-nypnib0h	502	33	the	the	DT
cord-021419-nypnib0h	502	34	7	7	CD
cord-021419-nypnib0h	502	35	and	and	CC
cord-021419-nypnib0h	502	36	10	10	CD
cord-021419-nypnib0h	502	37	positions	position	NNS
cord-021419-nypnib0h	502	38	(	(	-LRB-
cord-021419-nypnib0h	502	39	S44HP	s44hp	NN
cord-021419-nypnib0h	502	40	and	and	CC
cord-021419-nypnib0h	502	41	BSG005	BSG005	NNP
cord-021419-nypnib0h	502	42	)	)	-RRB-
cord-021419-nypnib0h	502	43	exhibit	exhibit	VBP
cord-021419-nypnib0h	502	44	high	high	JJ
cord-021419-nypnib0h	502	45	activity	activity	NN
cord-021419-nypnib0h	502	46	.	.	.
cord-021419-nypnib0h	503	1	A	a	DT
cord-021419-nypnib0h	503	2	series	series	NN
cord-021419-nypnib0h	503	3	of	of	IN
cord-021419-nypnib0h	503	4	new	new	JJ
cord-021419-nypnib0h	503	5	semi	semi	JJ
cord-021419-nypnib0h	503	6	-	-	JJ
cord-021419-nypnib0h	503	7	synthetic	synthetic	JJ
cord-021419-nypnib0h	503	8	derivatives	derivative	NNS
cord-021419-nypnib0h	503	9	were	be	VBD
cord-021419-nypnib0h	503	10	shown	show	VBN
cord-021419-nypnib0h	503	11	to	to	TO
cord-021419-nypnib0h	503	12	have	have	VB
cord-021419-nypnib0h	503	13	pore	pore	NN
cord-021419-nypnib0h	503	14	-	-	HYPH
cord-021419-nypnib0h	503	15	forming	form	VBG
cord-021419-nypnib0h	503	16	ability	ability	NN
cord-021419-nypnib0h	503	17	in	in	IN
cord-021419-nypnib0h	503	18	artificially	artificially	RB
cord-021419-nypnib0h	503	19	formed	form	VBN
cord-021419-nypnib0h	503	20	sterol	sterol	NN
cord-021419-nypnib0h	503	21	-	-	HYPH
cord-021419-nypnib0h	503	22	containing	contain	VBG
cord-021419-nypnib0h	503	23	membranes	membrane	NNS
cord-021419-nypnib0h	503	24	.	.	.
cord-021419-nypnib0h	504	1	It	-PRON-	PRP
cord-021419-nypnib0h	504	2	is	be	VBZ
cord-021419-nypnib0h	504	3	worth	worth	JJ
cord-021419-nypnib0h	504	4	noting	note	VBG
cord-021419-nypnib0h	504	5	that	that	IN
cord-021419-nypnib0h	504	6	they	-PRON-	PRP
cord-021419-nypnib0h	504	7	have	have	VBP
cord-021419-nypnib0h	504	8	selective	selective	JJ
cord-021419-nypnib0h	504	9	activity	activity	NN
cord-021419-nypnib0h	504	10	against	against	IN
cord-021419-nypnib0h	504	11	ergosterol	ergosterol	NN
cord-021419-nypnib0h	504	12	-	-	HYPH
cord-021419-nypnib0h	504	13	containing	contain	VBG
cord-021419-nypnib0h	504	14	fungal	fungal	JJ
cord-021419-nypnib0h	504	15	membranes	membrane	NNS
cord-021419-nypnib0h	504	16	and	and	CC
cord-021419-nypnib0h	504	17	lower	low	JJR
cord-021419-nypnib0h	504	18	haemolysis	haemolysis	NN
cord-021419-nypnib0h	504	19	compared	compare	VBN
cord-021419-nypnib0h	504	20	to	to	IN
cord-021419-nypnib0h	504	21	amphotericin	amphotericin	NNS
cord-021419-nypnib0h	504	22	B.	B.	NNP
cord-021419-nypnib0h	505	1	The	the	DT
cord-021419-nypnib0h	505	2	aim	aim	NN
cord-021419-nypnib0h	505	3	of	of	IN
cord-021419-nypnib0h	505	4	chemical	chemical	JJ
cord-021419-nypnib0h	505	5	modifications	modification	NNS
cord-021419-nypnib0h	505	6	of	of	IN
cord-021419-nypnib0h	505	7	the	the	DT
cord-021419-nypnib0h	505	8	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	505	9	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	505	10	A	A	NNP
cord-021419-nypnib0h	505	11	(	(	-LRB-
cord-021419-nypnib0h	505	12	90a	90a	NNS
cord-021419-nypnib0h	505	13	)	)	-RRB-
cord-021419-nypnib0h	506	1	(	(	-LRB-
cord-021419-nypnib0h	506	2	Fig	Fig	NNP
cord-021419-nypnib0h	506	3	.	.	.
cord-021419-nypnib0h	507	1	6	6	LS
cord-021419-nypnib0h	507	2	)	)	-RRB-
cord-021419-nypnib0h	507	3	acting	act	VBG
cord-021419-nypnib0h	507	4	as	as	IN
cord-021419-nypnib0h	507	5	the	the	DT
cord-021419-nypnib0h	507	6	F	F	NNP
cord-021419-nypnib0h	507	7	0	0	CD
cord-021419-nypnib0h	507	8	F	F	NNP
cord-021419-nypnib0h	507	9	1	1	CD
cord-021419-nypnib0h	507	10	-ATP	-ATP	:
cord-021419-nypnib0h	507	11	synthase	synthase	NN
cord-021419-nypnib0h	507	12	inhibitor	inhibitor	NN
cord-021419-nypnib0h	507	13	is	be	VBZ
cord-021419-nypnib0h	507	14	to	to	TO
cord-021419-nypnib0h	507	15	prepare	prepare	VB
cord-021419-nypnib0h	507	16	new	new	JJ
cord-021419-nypnib0h	507	17	analogues	analogue	NNS
cord-021419-nypnib0h	507	18	possessing	possess	VBG
cord-021419-nypnib0h	507	19	selective	selective	JJ
cord-021419-nypnib0h	507	20	antitumour	antitumour	NN
cord-021419-nypnib0h	507	21	or	or	CC
cord-021419-nypnib0h	507	22	anti	anti	JJ
cord-021419-nypnib0h	507	23	-	-	JJ
cord-021419-nypnib0h	507	24	infective	infective	JJ
cord-021419-nypnib0h	507	25	activity	activity	NN
cord-021419-nypnib0h	507	26	and	and	CC
cord-021419-nypnib0h	507	27	to	to	TO
cord-021419-nypnib0h	507	28	elucidate	elucidate	VB
cord-021419-nypnib0h	507	29	the	the	DT
cord-021419-nypnib0h	507	30	mechanisms	mechanism	NNS
cord-021419-nypnib0h	507	31	of	of	IN
cord-021419-nypnib0h	507	32	sensitivity	sensitivity	NN
cord-021419-nypnib0h	507	33	of	of	IN
cord-021419-nypnib0h	507	34	microorganisms	microorganism	NNS
cord-021419-nypnib0h	507	35	to	to	IN
cord-021419-nypnib0h	507	36	this	this	DT
cord-021419-nypnib0h	507	37	agent	agent	NN
cord-021419-nypnib0h	507	38	.	.	.
cord-021419-nypnib0h	508	1	Oligomycin	Oligomycin	NNP
cord-021419-nypnib0h	508	2	A	A	NNP
cord-021419-nypnib0h	508	3	(	(	-LRB-
cord-021419-nypnib0h	508	4	90a	90a	NNS
cord-021419-nypnib0h	508	5	)	)	-RRB-
cord-021419-nypnib0h	508	6	(	(	-LRB-
cord-021419-nypnib0h	508	7	hereinafter	hereinafter	NNP
cord-021419-nypnib0h	508	8	oligomycin	oligomycin	NNP
cord-021419-nypnib0h	508	9	)	)	-RRB-
cord-021419-nypnib0h	508	10	belongs	belong	VBZ
cord-021419-nypnib0h	508	11	to	to	IN
cord-021419-nypnib0h	508	12	macrolides	macrolide	NNS
cord-021419-nypnib0h	508	13	Ð	Ð	NNP
cord-021419-nypnib0h	508	14	26-membered	26-membered	CD
cord-021419-nypnib0h	508	15	a	a	DT
cord-021419-nypnib0h	508	16	,	,	,
cord-021419-nypnib0h	508	17	b	b	NN
cord-021419-nypnib0h	508	18	-	-	HYPH
cord-021419-nypnib0h	508	19	unsubstituted	unsubstitute	VBN
cord-021419-nypnib0h	508	20	macrolactones	macrolactone	NNS
cord-021419-nypnib0h	508	21	.	.	.
cord-021419-nypnib0h	509	1	It	-PRON-	PRP
cord-021419-nypnib0h	509	2	is	be	VBZ
cord-021419-nypnib0h	509	3	a	a	DT
cord-021419-nypnib0h	509	4	highly	highly	RB
cord-021419-nypnib0h	509	5	specific	specific	JJ
cord-021419-nypnib0h	509	6	inhibitor	inhibitor	NN
cord-021419-nypnib0h	509	7	of	of	IN
cord-021419-nypnib0h	509	8	oxidative	oxidative	JJ
cord-021419-nypnib0h	509	9	phosphorylation	phosphorylation	NN
cord-021419-nypnib0h	509	10	in	in	IN
cord-021419-nypnib0h	509	11	the	the	DT
cord-021419-nypnib0h	509	12	mitochondria	mitochondrion	NNS
cord-021419-nypnib0h	509	13	of	of	IN
cord-021419-nypnib0h	509	14	eukaryotes	eukaryote	NNS
cord-021419-nypnib0h	509	15	.	.	.
cord-021419-nypnib0h	510	1	Oligomycin	Oligomycin	NNP
cord-021419-nypnib0h	510	2	inhibits	inhibit	VBZ
cord-021419-nypnib0h	510	3	adenosine	adenosine	NN
cord-021419-nypnib0h	510	4	triphosphate	triphosphate	NN
cord-021419-nypnib0h	510	5	(	(	-LRB-
cord-021419-nypnib0h	510	6	ATP	ATP	NNP
cord-021419-nypnib0h	510	7	)	)	-RRB-
cord-021419-nypnib0h	510	8	synthesis	synthesis	NN
cord-021419-nypnib0h	510	9	and	and	CC
cord-021419-nypnib0h	510	10	causes	cause	VBZ
cord-021419-nypnib0h	510	11	cell	cell	NN
cord-021419-nypnib0h	510	12	death	death	NN
cord-021419-nypnib0h	510	13	.	.	.
cord-021419-nypnib0h	511	1	Note	note	VB
cord-021419-nypnib0h	511	2	.	.	.
cord-021419-nypnib0h	512	1	CErg	CErg	NNP
cord-021419-nypnib0h	512	2	is	be	VBZ
cord-021419-nypnib0h	512	3	the	the	DT
cord-021419-nypnib0h	512	4	minimum	minimum	JJ
cord-021419-nypnib0h	512	5	concentration	concentration	NN
cord-021419-nypnib0h	512	6	of	of	IN
cord-021419-nypnib0h	512	7	the	the	DT
cord-021419-nypnib0h	512	8	compound	compound	NN
cord-021419-nypnib0h	512	9	that	that	WDT
cord-021419-nypnib0h	512	10	causes	cause	VBZ
cord-021419-nypnib0h	512	11	the	the	DT
cord-021419-nypnib0h	512	12	pore	pore	NN
cord-021419-nypnib0h	512	13	formation	formation	NN
cord-021419-nypnib0h	512	14	in	in	IN
cord-021419-nypnib0h	512	15	the	the	DT
cord-021419-nypnib0h	512	16	DPhPC	DPhPC	NNP
cord-021419-nypnib0h	512	17	/	/	SYM
cord-021419-nypnib0h	512	18	Erg	Erg	NNP
cord-021419-nypnib0h	512	19	bilayer	bilayer	NN
cord-021419-nypnib0h	512	20	;	;	:
cord-021419-nypnib0h	512	21	CChol	CChol	NNP
cord-021419-nypnib0h	512	22	/	/	SYM
cord-021419-nypnib0h	512	23	CErg	CErg	NNP
cord-021419-nypnib0h	512	24	is	be	VBZ
cord-021419-nypnib0h	512	25	the	the	DT
cord-021419-nypnib0h	512	26	ratio	ratio	NN
cord-021419-nypnib0h	512	27	of	of	IN
cord-021419-nypnib0h	512	28	the	the	DT
cord-021419-nypnib0h	512	29	minimum	minimum	JJ
cord-021419-nypnib0h	512	30	concentrations	concentration	NNS
cord-021419-nypnib0h	512	31	of	of	IN
cord-021419-nypnib0h	512	32	the	the	DT
cord-021419-nypnib0h	512	33	polyene	polyene	NN
cord-021419-nypnib0h	512	34	in	in	IN
cord-021419-nypnib0h	512	35	the	the	DT
cord-021419-nypnib0h	512	36	DPhPC	DPhPC	NNP
cord-021419-nypnib0h	512	37	/	/	SYM
cord-021419-nypnib0h	512	38	Chol	Chol	NNP
cord-021419-nypnib0h	512	39	and	and	CC
cord-021419-nypnib0h	513	1	DPhPC	DPhPC	NNP
cord-021419-nypnib0h	513	2	/	/	SYM
cord-021419-nypnib0h	513	3	Erg	Erg	NNP
cord-021419-nypnib0h	513	4	bilayers	bilayer	NNS
cord-021419-nypnib0h	514	1	(	(	-LRB-
cord-021419-nypnib0h	514	2	DPhPC	DPhPC	NNP
cord-021419-nypnib0h	514	3	is	be	VBZ
cord-021419-nypnib0h	514	4	1,2-diphytanoyl	1,2-diphytanoyl	CD
cord-021419-nypnib0h	514	5	-	-	HYPH
cord-021419-nypnib0h	514	6	sn	sn	NN
cord-021419-nypnib0h	514	7	-	-	HYPH
cord-021419-nypnib0h	514	8	glycero-3-phosphocholine	glycero-3-phosphocholine	NN
cord-021419-nypnib0h	515	1	,	,	,
cord-021419-nypnib0h	515	2	Chol	Chol	NNP
cord-021419-nypnib0h	515	3	is	be	VBZ
cord-021419-nypnib0h	515	4	cholesterol	cholesterol	NN
cord-021419-nypnib0h	515	5	,	,	,
cord-021419-nypnib0h	515	6	Erg	Erg	NNP
cord-021419-nypnib0h	515	7	is	be	VBZ
cord-021419-nypnib0h	515	8	ergosterol	ergosterol	NN
cord-021419-nypnib0h	515	9	)	)	-RRB-
cord-021419-nypnib0h	515	10	.	.	.
cord-021419-nypnib0h	515	11	 	 	_SP
cord-021419-nypnib0h	516	1	The	the	DT
cord-021419-nypnib0h	516	2	oligomycin	oligomycin	NN
cord-021419-nypnib0h	516	3	molecule	molecule	NN
cord-021419-nypnib0h	516	4	(	(	-LRB-
cord-021419-nypnib0h	516	5	90a	90a	NNS
cord-021419-nypnib0h	516	6	)	)	-RRB-
cord-021419-nypnib0h	516	7	was	be	VBD
cord-021419-nypnib0h	516	8	found	find	VBN
cord-021419-nypnib0h	516	9	to	to	TO
cord-021419-nypnib0h	516	10	contain	contain	VB
cord-021419-nypnib0h	516	11	a	a	DT
cord-021419-nypnib0h	516	12	functional	functional	JJ
cord-021419-nypnib0h	516	13	group	group	NN
cord-021419-nypnib0h	516	14	,	,	,
cord-021419-nypnib0h	516	15	the	the	DT
cord-021419-nypnib0h	516	16	chemical	chemical	JJ
cord-021419-nypnib0h	516	17	modification	modification	NN
cord-021419-nypnib0h	516	18	of	of	IN
cord-021419-nypnib0h	516	19	which	which	WDT
cord-021419-nypnib0h	516	20	can	can	MD
cord-021419-nypnib0h	516	21	produce	produce	VB
cord-021419-nypnib0h	516	22	the	the	DT
cord-021419-nypnib0h	516	23	largest	large	JJS
cord-021419-nypnib0h	516	24	number	number	NN
cord-021419-nypnib0h	516	25	of	of	IN
cord-021419-nypnib0h	516	26	semi	semi	JJ
cord-021419-nypnib0h	516	27	-	-	JJ
cord-021419-nypnib0h	516	28	synthetic	synthetic	JJ
cord-021419-nypnib0h	516	29	analogues	analogue	NNS
cord-021419-nypnib0h	516	30	with	with	IN
cord-021419-nypnib0h	516	31	various	various	JJ
cord-021419-nypnib0h	516	32	biological	biological	JJ
cord-021419-nypnib0h	516	33	activities	activity	NNS
cord-021419-nypnib0h	516	34	.	.	.
cord-021419-nypnib0h	517	1	The	the	DT
cord-021419-nypnib0h	517	2	docking	docking	NN
cord-021419-nypnib0h	517	3	study	study	NN
cord-021419-nypnib0h	517	4	of	of	IN
cord-021419-nypnib0h	517	5	the	the	DT
cord-021419-nypnib0h	517	6	interaction	interaction	NN
cord-021419-nypnib0h	517	7	between	between	IN
cord-021419-nypnib0h	517	8	the	the	DT
cord-021419-nypnib0h	517	9	antibiotic	antibiotic	NN
cord-021419-nypnib0h	517	10	and	and	CC
cord-021419-nypnib0h	517	11	the	the	DT
cord-021419-nypnib0h	517	12	target	target	NN
cord-021419-nypnib0h	517	13	of	of	IN
cord-021419-nypnib0h	517	14	the	the	DT
cord-021419-nypnib0h	517	15	enzyme	enzyme	NN
cord-021419-nypnib0h	517	16	F	f	NN
cord-021419-nypnib0h	517	17	0	0	CD
cord-021419-nypnib0h	517	18	F	F	NNP
cord-021419-nypnib0h	517	19	1	1	CD
cord-021419-nypnib0h	517	20	-ATP	-ATP	:
cord-021419-nypnib0h	517	21	synthase	synthase	NNP
cord-021419-nypnib0h	517	22	showed	show	VBD
cord-021419-nypnib0h	517	23	that	that	IN
cord-021419-nypnib0h	517	24	the	the	DT
cord-021419-nypnib0h	517	25	C(32)7C	C(32)7C	NNP
cord-021419-nypnib0h	517	26	(	(	-LRB-
cord-021419-nypnib0h	517	27	34	34	CD
cord-021419-nypnib0h	517	28	)	)	-RRB-
cord-021419-nypnib0h	517	29	side	side	NN
cord-021419-nypnib0h	517	30	chain	chain	NN
cord-021419-nypnib0h	517	31	is	be	VBZ
cord-021419-nypnib0h	517	32	not	not	RB
cord-021419-nypnib0h	517	33	directly	directly	RB
cord-021419-nypnib0h	517	34	involved	involve	VBN
cord-021419-nypnib0h	517	35	in	in	IN
cord-021419-nypnib0h	517	36	the	the	DT
cord-021419-nypnib0h	517	37	formation	formation	NN
cord-021419-nypnib0h	517	38	of	of	IN
cord-021419-nypnib0h	517	39	this	this	DT
cord-021419-nypnib0h	517	40	complex	complex	NN
cord-021419-nypnib0h	517	41	.	.	.
cord-021419-nypnib0h	518	1	54	54	CD
cord-021419-nypnib0h	519	1	A	a	DT
cord-021419-nypnib0h	519	2	series	series	NN
cord-021419-nypnib0h	519	3	of	of	IN
cord-021419-nypnib0h	519	4	33-substituted	33-substituted	CD
cord-021419-nypnib0h	519	5	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	519	6	derivatives	derivative	NNS
cord-021419-nypnib0h	519	7	were	be	VBD
cord-021419-nypnib0h	519	8	synthesized	synthesize	VBN
cord-021419-nypnib0h	519	9	using	use	VBG
cord-021419-nypnib0h	519	10	33-deoxy	33-deoxy	CD
cord-021419-nypnib0h	519	11	-	-	HYPH
cord-021419-nypnib0h	519	12	O	o	NN
cord-021419-nypnib0h	519	13	-	-	HYPH
cord-021419-nypnib0h	519	14	mesyl	mesyl	NN
cord-021419-nypnib0h	519	15	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	519	16	(	(	-LRB-
cord-021419-nypnib0h	519	17	91	91	CD
cord-021419-nypnib0h	519	18	)	)	-RRB-
cord-021419-nypnib0h	519	19	as	as	IN
cord-021419-nypnib0h	519	20	the	the	DT
cord-021419-nypnib0h	519	21	key	key	JJ
cord-021419-nypnib0h	519	22	compound	compound	NN
cord-021419-nypnib0h	519	23	,	,	,
cord-021419-nypnib0h	519	24	which	which	WDT
cord-021419-nypnib0h	519	25	was	be	VBD
cord-021419-nypnib0h	519	26	prepared	prepare	VBN
cord-021419-nypnib0h	519	27	by	by	IN
cord-021419-nypnib0h	519	28	the	the	DT
cord-021419-nypnib0h	519	29	selective	selective	JJ
cord-021419-nypnib0h	519	30	treatment	treatment	NN
cord-021419-nypnib0h	519	31	of	of	IN
cord-021419-nypnib0h	519	32	90a	90a	NNS
cord-021419-nypnib0h	519	33	with	with	IN
cord-021419-nypnib0h	519	34	methanesulfonyl	methanesulfonyl	JJ
cord-021419-nypnib0h	519	35	chloride	chloride	NN
cord-021419-nypnib0h	519	36	in	in	IN
cord-021419-nypnib0h	519	37	a	a	DT
cord-021419-nypnib0h	519	38	DMAP	DMAP	NNP
cord-021419-nypnib0h	519	39	±	±	NNP
cord-021419-nypnib0h	519	40	Py	py	NN
cord-021419-nypnib0h	519	41	mixture	mixture	NN
cord-021419-nypnib0h	519	42	(	(	-LRB-
cord-021419-nypnib0h	519	43	Scheme	scheme	NN
cord-021419-nypnib0h	519	44	25	25	CD
cord-021419-nypnib0h	519	45	)	)	-RRB-
cord-021419-nypnib0h	519	46	.	.	.
cord-021419-nypnib0h	520	1	55	55	CD
cord-021419-nypnib0h	521	1	The	the	DT
cord-021419-nypnib0h	521	2	nucleophilic	nucleophilic	JJ
cord-021419-nypnib0h	521	3	substitution	substitution	NN
cord-021419-nypnib0h	521	4	of	of	IN
cord-021419-nypnib0h	521	5	the	the	DT
cord-021419-nypnib0h	521	6	group	group	NN
cord-021419-nypnib0h	521	7	R	r	NN
cord-021419-nypnib0h	521	8	via	via	IN
cord-021419-nypnib0h	521	9	the	the	DT
cord-021419-nypnib0h	521	10	S	S	NNP
cord-021419-nypnib0h	521	11	N	N	NNP
cord-021419-nypnib0h	521	12	2	2	CD
cord-021419-nypnib0h	521	13	or	or	CC
cord-021419-nypnib0h	521	14	S	S	NNP
cord-021419-nypnib0h	521	15	N	n	NN
cord-021419-nypnib0h	521	16	1	1	CD
cord-021419-nypnib0h	521	17	mechanism	mechanism	NN
cord-021419-nypnib0h	521	18	using	use	VBG
cord-021419-nypnib0h	521	19	various	various	JJ
cord-021419-nypnib0h	521	20	reagents	reagent	NNS
cord-021419-nypnib0h	521	21	gave	give	VBD
cord-021419-nypnib0h	521	22	the	the	DT
cord-021419-nypnib0h	521	23	following	following	JJ
cord-021419-nypnib0h	521	24	33-substituted	33-substituted	CD
cord-021419-nypnib0h	521	25	derivatives	derivative	NNS
cord-021419-nypnib0h	521	26	:	:	:
cord-021419-nypnib0h	522	1	33-(S)-oligomycin	33-(S)-oligomycin	NNS
cord-021419-nypnib0h	522	2	A	a	DT
cord-021419-nypnib0h	522	3	(	(	-LRB-
cord-021419-nypnib0h	522	4	90b	90b	NNS
cord-021419-nypnib0h	522	5	)	)	-RRB-
cord-021419-nypnib0h	522	6	,	,	,
cord-021419-nypnib0h	522	7	56	56	CD
cord-021419-nypnib0h	522	8	33-deoxy-33-(S)-thiocyanooligomycin	33-deoxy-33-(S)-thiocyanooligomycin	NNS
cord-021419-nypnib0h	522	9	(	(	-LRB-
cord-021419-nypnib0h	522	10	92	92	CD
cord-021419-nypnib0h	522	11	)	)	-RRB-
cord-021419-nypnib0h	522	12	,	,	,
cord-021419-nypnib0h	522	13	57	57	CD
cord-021419-nypnib0h	522	14	33-deoxy-33-(R	33-deoxy-33-(r	NN
cord-021419-nypnib0h	522	15	,	,	,
cord-021419-nypnib0h	522	16	S)-bromooligomycin	S)-bromooligomycin	NNP
cord-021419-nypnib0h	522	17	(	(	-LRB-
cord-021419-nypnib0h	522	18	93	93	CD
cord-021419-nypnib0h	522	19	)	)	-RRB-
cord-021419-nypnib0h	522	20	58	58	CD
cord-021419-nypnib0h	522	21	and	and	CC
cord-021419-nypnib0h	523	1	33-deoxy-33-(S)-azidooligomycin	33-deoxy-33-(s)-azidooligomycin	LS
cord-021419-nypnib0h	523	2	(	(	-LRB-
cord-021419-nypnib0h	523	3	94	94	CD
cord-021419-nypnib0h	523	4	)	)	-RRB-
cord-021419-nypnib0h	523	5	55	55	CD
cord-021419-nypnib0h	524	1	(	(	-LRB-
cord-021419-nypnib0h	524	2	see	see	VB
cord-021419-nypnib0h	524	3	Scheme	Scheme	NNP
cord-021419-nypnib0h	524	4	25	25	CD
cord-021419-nypnib0h	524	5	)	)	-RRB-
cord-021419-nypnib0h	524	6	.	.	.
cord-021419-nypnib0h	525	1	The	the	DT
cord-021419-nypnib0h	525	2	racemization	racemization	NN
cord-021419-nypnib0h	525	3	is	be	VBZ
cord-021419-nypnib0h	525	4	observed	observe	VBN
cord-021419-nypnib0h	525	5	only	only	RB
cord-021419-nypnib0h	525	6	for	for	IN
cord-021419-nypnib0h	525	7	33bromo	33bromo	CD
cord-021419-nypnib0h	525	8	derivative	derivative	JJ
cord-021419-nypnib0h	525	9	93	93	CD
cord-021419-nypnib0h	525	10	.	.	.
cord-021419-nypnib0h	526	1	The	the	DT
cord-021419-nypnib0h	526	2	33-epimer	33-epimer	CD
cord-021419-nypnib0h	526	3	of	of	IN
cord-021419-nypnib0h	526	4	this	this	DT
cord-021419-nypnib0h	526	5	antibiotic	antibiotic	NN
cord-021419-nypnib0h	526	6	,	,	,
cord-021419-nypnib0h	526	7	33-(S)-oligomycin	33-(S)-oligomycin	NNP
cord-021419-nypnib0h	526	8	A	a	DT
cord-021419-nypnib0h	526	9	(	(	-LRB-
cord-021419-nypnib0h	526	10	90b	90b	NNS
cord-021419-nypnib0h	526	11	)	)	-RRB-
cord-021419-nypnib0h	526	12	,	,	,
cord-021419-nypnib0h	526	13	was	be	VBD
cord-021419-nypnib0h	526	14	synthesized	synthesize	VBN
cord-021419-nypnib0h	526	15	by	by	IN
cord-021419-nypnib0h	526	16	the	the	DT
cord-021419-nypnib0h	526	17	solvolysis	solvolysis	NN
cord-021419-nypnib0h	526	18	of	of	IN
cord-021419-nypnib0h	526	19	33-(R)-deoxy	33-(R)-deoxy	NNP
cord-021419-nypnib0h	526	20	-	-	HYPH
cord-021419-nypnib0h	526	21	Omesyl	Omesyl	NNP
cord-021419-nypnib0h	526	22	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	526	23	(	(	-LRB-
cord-021419-nypnib0h	526	24	91	91	CD
cord-021419-nypnib0h	526	25	)	)	-RRB-
cord-021419-nypnib0h	526	26	with	with	IN
cord-021419-nypnib0h	526	27	an	an	DT
cord-021419-nypnib0h	526	28	aqueous	aqueous	JJ
cord-021419-nypnib0h	526	29	mixture	mixture	NN
cord-021419-nypnib0h	526	30	of	of	IN
cord-021419-nypnib0h	526	31	tiourea	tiourea	NN
cord-021419-nypnib0h	526	32	and	and	CC
cord-021419-nypnib0h	526	33	methyl	methyl	NN
cord-021419-nypnib0h	526	34	cellosolve	cellosolve	NN
cord-021419-nypnib0h	526	35	on	on	IN
cord-021419-nypnib0h	526	36	heating	heating	NN
cord-021419-nypnib0h	526	37	.	.	.
cord-021419-nypnib0h	527	1	The	the	DT
cord-021419-nypnib0h	527	2	reaction	reaction	NN
cord-021419-nypnib0h	527	3	involves	involve	VBZ
cord-021419-nypnib0h	527	4	the	the	DT
cord-021419-nypnib0h	527	5	Walden	Walden	NNP
cord-021419-nypnib0h	527	6	inversion	inversion	NN
cord-021419-nypnib0h	527	7	of	of	IN
cord-021419-nypnib0h	527	8	configuration	configuration	NN
cord-021419-nypnib0h	527	9	at	at	IN
cord-021419-nypnib0h	527	10	the	the	DT
cord-021419-nypnib0h	527	11	C(33	C(33	NNP
cord-021419-nypnib0h	527	12	)	)	-RRB-
cord-021419-nypnib0h	527	13	atom	atom	NN
cord-021419-nypnib0h	527	14	through	through	IN
cord-021419-nypnib0h	527	15	a	a	DT
cord-021419-nypnib0h	527	16	plausible	plausible	JJ
cord-021419-nypnib0h	527	17	mechanism	mechanism	NN
cord-021419-nypnib0h	527	18	presented	present	VBN
cord-021419-nypnib0h	527	19	in	in	IN
cord-021419-nypnib0h	527	20	Scheme	Scheme	NNP
cord-021419-nypnib0h	527	21	25	25	CD
cord-021419-nypnib0h	527	22	.	.	.
cord-021419-nypnib0h	528	1	The	the	DT
cord-021419-nypnib0h	528	2	biological	biological	JJ
cord-021419-nypnib0h	528	3	activity	activity	NN
cord-021419-nypnib0h	528	4	assay	assay	NN
cord-021419-nypnib0h	528	5	of	of	IN
cord-021419-nypnib0h	528	6	compound	compound	NN
cord-021419-nypnib0h	528	7	90b	90b	NNS
cord-021419-nypnib0h	528	8	revealed	reveal	VBD
cord-021419-nypnib0h	528	9	that	that	IN
cord-021419-nypnib0h	528	10	the	the	DT
cord-021419-nypnib0h	528	11	inversion	inversion	NN
cord-021419-nypnib0h	528	12	of	of	IN
cord-021419-nypnib0h	528	13	the	the	DT
cord-021419-nypnib0h	528	14	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	528	15	group	group	NN
cord-021419-nypnib0h	528	16	decreases	decrease	VBZ
cord-021419-nypnib0h	528	17	activity	activity	NN
cord-021419-nypnib0h	528	18	against	against	IN
cord-021419-nypnib0h	528	19	the	the	DT
cord-021419-nypnib0h	528	20	actinobacteria	actinobacteria	NNP
cord-021419-nypnib0h	528	21	Streptomyces	Streptomyces	NNP
cord-021419-nypnib0h	528	22	fradiae	fradiae	NN
cord-021419-nypnib0h	528	23	,	,	,
cord-021419-nypnib0h	528	24	while	while	IN
cord-021419-nypnib0h	528	25	the	the	DT
cord-021419-nypnib0h	528	26	antifungal	antifungal	JJ
cord-021419-nypnib0h	528	27	activity	activity	NN
cord-021419-nypnib0h	528	28	remains	remain	VBZ
cord-021419-nypnib0h	528	29	at	at	IN
cord-021419-nypnib0h	528	30	the	the	DT
cord-021419-nypnib0h	528	31	same	same	JJ
cord-021419-nypnib0h	528	32	level	level	NN
cord-021419-nypnib0h	528	33	.	.	.
cord-021419-nypnib0h	529	1	33-(S)-Oligomycin	33-(s)-oligomycin	CD
cord-021419-nypnib0h	529	2	A	a	NN
cord-021419-nypnib0h	529	3	(	(	-LRB-
cord-021419-nypnib0h	529	4	90b	90b	NNS
cord-021419-nypnib0h	529	5	)	)	-RRB-
cord-021419-nypnib0h	529	6	exhibits	exhibit	VBZ
cord-021419-nypnib0h	529	7	somewhat	somewhat	RB
cord-021419-nypnib0h	529	8	higher	high	JJR
cord-021419-nypnib0h	529	9	activity	activity	NN
cord-021419-nypnib0h	529	10	against	against	IN
cord-021419-nypnib0h	529	11	tumour	tumour	NN
cord-021419-nypnib0h	529	12	cells	cell	NNS
cord-021419-nypnib0h	529	13	compared	compare	VBN
cord-021419-nypnib0h	529	14	to	to	IN
cord-021419-nypnib0h	529	15	the	the	DT
cord-021419-nypnib0h	529	16	starting	start	VBG
cord-021419-nypnib0h	529	17	analogue	analogue	NN
cord-021419-nypnib0h	529	18	90a	90a	NNS
cord-021419-nypnib0h	529	19	.	.	.
cord-021419-nypnib0h	530	1	Both	both	DT
cord-021419-nypnib0h	530	2	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	530	3	are	be	VBP
cord-021419-nypnib0h	530	4	able	able	JJ
cord-021419-nypnib0h	530	5	to	to	TO
cord-021419-nypnib0h	530	6	overcome	overcome	VB
cord-021419-nypnib0h	530	7	different	different	JJ
cord-021419-nypnib0h	530	8	drug	drug	NN
cord-021419-nypnib0h	530	9	resistance	resistance	NN
cord-021419-nypnib0h	530	10	phenotypes	phenotype	NNS
cord-021419-nypnib0h	530	11	and	and	CC
cord-021419-nypnib0h	530	12	have	have	VBP
cord-021419-nypnib0h	530	13	low	low	JJ
cord-021419-nypnib0h	530	14	toxicity	toxicity	NN
cord-021419-nypnib0h	530	15	to	to	IN
cord-021419-nypnib0h	530	16	non	non	JJ
cord-021419-nypnib0h	530	17	-	-	JJ
cord-021419-nypnib0h	530	18	malignant	malignant	JJ
cord-021419-nypnib0h	530	19	cells	cell	NNS
cord-021419-nypnib0h	530	20	.	.	.
cord-021419-nypnib0h	531	1	56	56	CD
cord-021419-nypnib0h	532	1	The	the	DT
cord-021419-nypnib0h	532	2	treatment	treatment	NN
cord-021419-nypnib0h	532	3	of	of	IN
cord-021419-nypnib0h	532	4	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	532	5	91	91	CD
cord-021419-nypnib0h	532	6	with	with	IN
cord-021419-nypnib0h	532	7	98	98	CD
cord-021419-nypnib0h	532	8	%	%	NN
cord-021419-nypnib0h	532	9	formic	formic	JJ
cord-021419-nypnib0h	532	10	acid	acid	NN
cord-021419-nypnib0h	532	11	afforded	afford	VBN
cord-021419-nypnib0h	532	12	C(33)-O	c(33)-o	NN
cord-021419-nypnib0h	532	13	-	-	HYPH
cord-021419-nypnib0h	532	14	formyloligomycin	formyloligomycin	NNS
cord-021419-nypnib0h	532	15	(	(	-LRB-
cord-021419-nypnib0h	532	16	95	95	CD
cord-021419-nypnib0h	532	17	)	)	-RRB-
cord-021419-nypnib0h	532	18	59	59	CD
cord-021419-nypnib0h	533	1	(	(	-LRB-
cord-021419-nypnib0h	533	2	see	see	VB
cord-021419-nypnib0h	533	3	Scheme	Scheme	NNP
cord-021419-nypnib0h	533	4	25	25	CD
cord-021419-nypnib0h	533	5	)	)	-RRB-
cord-021419-nypnib0h	533	6	.	.	.
cord-021419-nypnib0h	534	1	Formylated	formylated	JJ
cord-021419-nypnib0h	534	2	derivative	derivative	NNP
cord-021419-nypnib0h	534	3	95	95	CD
cord-021419-nypnib0h	534	4	retains	retain	VBZ
cord-021419-nypnib0h	534	5	the	the	DT
cord-021419-nypnib0h	534	6	ability	ability	NN
cord-021419-nypnib0h	534	7	to	to	TO
cord-021419-nypnib0h	534	8	inhibit	inhibit	VB
cord-021419-nypnib0h	534	9	tumour	tumour	NN
cord-021419-nypnib0h	534	10	cell	cell	NN
cord-021419-nypnib0h	534	11	growth	growth	NN
cord-021419-nypnib0h	534	12	,	,	,
cord-021419-nypnib0h	534	13	whereas	whereas	IN
cord-021419-nypnib0h	534	14	the	the	DT
cord-021419-nypnib0h	534	15	activity	activity	NN
cord-021419-nypnib0h	534	16	against	against	IN
cord-021419-nypnib0h	534	17	most	most	JJS
cord-021419-nypnib0h	534	18	other	other	JJ
cord-021419-nypnib0h	534	19	test	test	NN
cord-021419-nypnib0h	534	20	cultures	culture	NNS
cord-021419-nypnib0h	534	21	,	,	,
cord-021419-nypnib0h	534	22	including	include	VBG
cord-021419-nypnib0h	534	23	non	non	JJ
cord-021419-nypnib0h	534	24	-	-	JJ
cord-021419-nypnib0h	534	25	malignant	malignant	JJ
cord-021419-nypnib0h	534	26	cells	cell	NNS
cord-021419-nypnib0h	534	27	,	,	,
cord-021419-nypnib0h	534	28	decreases	decrease	VBZ
cord-021419-nypnib0h	534	29	.	.	.
cord-021419-nypnib0h	535	1	Due	due	IN
cord-021419-nypnib0h	535	2	to	to	IN
cord-021419-nypnib0h	535	3	selectivity	selectivity	NN
cord-021419-nypnib0h	535	4	against	against	IN
cord-021419-nypnib0h	535	5	tumour	tumour	NN
cord-021419-nypnib0h	535	6	cells	cell	NNS
cord-021419-nypnib0h	535	7	,	,	,
cord-021419-nypnib0h	535	8	C(33)-O	c(33)-o	NN
cord-021419-nypnib0h	535	9	-	-	HYPH
cord-021419-nypnib0h	535	10	formyloligomycin	formyloligomycin	NNS
cord-021419-nypnib0h	535	11	(	(	-LRB-
cord-021419-nypnib0h	535	12	95	95	CD
cord-021419-nypnib0h	535	13	)	)	-RRB-
cord-021419-nypnib0h	535	14	holds	hold	VBZ
cord-021419-nypnib0h	535	15	promise	promise	NN
cord-021419-nypnib0h	535	16	for	for	IN
cord-021419-nypnib0h	535	17	further	further	JJ
cord-021419-nypnib0h	535	18	investigation	investigation	NN
cord-021419-nypnib0h	535	19	.	.	.
cord-021419-nypnib0h	536	1	33-Deoxy	33-deoxy	CD
cord-021419-nypnib0h	536	2	-	-	HYPH
cord-021419-nypnib0h	536	3	O	o	NN
cord-021419-nypnib0h	536	4	-	-	HYPH
cord-021419-nypnib0h	536	5	mesyl	mesyl	NN
cord-021419-nypnib0h	536	6	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	536	7	(	(	-LRB-
cord-021419-nypnib0h	536	8	91	91	CD
cord-021419-nypnib0h	536	9	)	)	-RRB-
cord-021419-nypnib0h	536	10	can	can	MD
cord-021419-nypnib0h	536	11	be	be	VB
cord-021419-nypnib0h	536	12	quantitatively	quantitatively	RB
cord-021419-nypnib0h	536	13	converted	convert	VBN
cord-021419-nypnib0h	536	14	into	into	IN
cord-021419-nypnib0h	536	15	33-dehydrooligomycin	33-dehydrooligomycin	CD
cord-021419-nypnib0h	536	16	(	(	-LRB-
cord-021419-nypnib0h	536	17	96	96	CD
cord-021419-nypnib0h	536	18	)	)	-RRB-
cord-021419-nypnib0h	536	19	by	by	IN
cord-021419-nypnib0h	536	20	the	the	DT
cord-021419-nypnib0h	536	21	Kornblum	Kornblum	NNP
cord-021419-nypnib0h	536	22	oxidation	oxidation	NN
cord-021419-nypnib0h	536	23	in	in	IN
cord-021419-nypnib0h	536	24	a	a	DT
cord-021419-nypnib0h	536	25	DMSO	DMSO	NNP
cord-021419-nypnib0h	536	26	±	±	NNP
cord-021419-nypnib0h	536	27	Et	Et	NNP
cord-021419-nypnib0h	536	28	3	3	CD
cord-021419-nypnib0h	536	29	N	n	CD
cord-021419-nypnib0h	536	30	mixture	mixture	NN
cord-021419-nypnib0h	536	31	at	at	IN
cord-021419-nypnib0h	536	32	105	105	CD
cord-021419-nypnib0h	536	33	8C	8c	CD
cord-021419-nypnib0h	536	34	(	(	-LRB-
cord-021419-nypnib0h	536	35	see	see	VB
cord-021419-nypnib0h	536	36	Scheme	Scheme	NNP
cord-021419-nypnib0h	536	37	25	25	CD
cord-021419-nypnib0h	536	38	)	)	-RRB-
cord-021419-nypnib0h	536	39	.	.	.
cord-021419-nypnib0h	537	1	54	54	CD
cord-021419-nypnib0h	538	1	Attempts	attempt	NNS
cord-021419-nypnib0h	538	2	to	to	TO
cord-021419-nypnib0h	538	3	oxidize	oxidize	VB
cord-021419-nypnib0h	538	4	the	the	DT
cord-021419-nypnib0h	538	5	OH	OH	NNP
cord-021419-nypnib0h	538	6	group	group	NN
cord-021419-nypnib0h	538	7	at	at	IN
cord-021419-nypnib0h	538	8	the	the	DT
cord-021419-nypnib0h	538	9	C(33	C(33	NNP
cord-021419-nypnib0h	538	10	)	)	-RRB-
cord-021419-nypnib0h	538	11	atom	atom	NN
cord-021419-nypnib0h	538	12	of	of	IN
cord-021419-nypnib0h	538	13	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	538	14	(	(	-LRB-
cord-021419-nypnib0h	538	15	90a	90a	NNS
cord-021419-nypnib0h	538	16	)	)	-RRB-
cord-021419-nypnib0h	538	17	to	to	IN
cord-021419-nypnib0h	538	18	the	the	DT
cord-021419-nypnib0h	538	19	keto	keto	NNP
cord-021419-nypnib0h	538	20	group	group	NN
cord-021419-nypnib0h	538	21	using	use	VBG
cord-021419-nypnib0h	538	22	different	different	JJ
cord-021419-nypnib0h	538	23	oxidizing	oxidizing	JJ
cord-021419-nypnib0h	538	24	agents	agent	NNS
cord-021419-nypnib0h	538	25	failed	fail	VBD
cord-021419-nypnib0h	538	26	.	.	.
cord-021419-nypnib0h	539	1	The	the	DT
cord-021419-nypnib0h	539	2	cited	cited	JJ
cord-021419-nypnib0h	539	3	study	study	NN
cord-021419-nypnib0h	539	4	is	be	VBZ
cord-021419-nypnib0h	539	5	interesting	interesting	JJ
cord-021419-nypnib0h	539	6	because	because	IN
cord-021419-nypnib0h	539	7	this	this	DT
cord-021419-nypnib0h	539	8	structure	structure	NN
cord-021419-nypnib0h	539	9	was	be	VBD
cord-021419-nypnib0h	539	10	previously	previously	RB
cord-021419-nypnib0h	539	11	presented	present	VBN
cord-021419-nypnib0h	539	12	as	as	IN
cord-021419-nypnib0h	539	13	a	a	DT
cord-021419-nypnib0h	539	14	new	new	JJ
cord-021419-nypnib0h	539	15	natural	natural	JJ
cord-021419-nypnib0h	539	16	compound	compound	NN
cord-021419-nypnib0h	539	17	.	.	.
cord-021419-nypnib0h	540	1	However	however	RB
cord-021419-nypnib0h	540	2	,	,	,
cord-021419-nypnib0h	540	3	the	the	DT
cord-021419-nypnib0h	540	4	structure	structure	NN
cord-021419-nypnib0h	540	5	of	of	IN
cord-021419-nypnib0h	540	6	this	this	DT
cord-021419-nypnib0h	540	7	compound	compound	NN
cord-021419-nypnib0h	540	8	was	be	VBD
cord-021419-nypnib0h	540	9	not	not	RB
cord-021419-nypnib0h	540	10	described	describe	VBN
cord-021419-nypnib0h	540	11	in	in	IN
cord-021419-nypnib0h	540	12	detail	detail	NN
cord-021419-nypnib0h	540	13	and	and	CC
cord-021419-nypnib0h	540	14	its	-PRON-	PRP$
cord-021419-nypnib0h	540	15	biological	biological	JJ
cord-021419-nypnib0h	540	16	activity	activity	NN
cord-021419-nypnib0h	540	17	was	be	VBD
cord-021419-nypnib0h	540	18	not	not	RB
cord-021419-nypnib0h	540	19	evaluated	evaluate	VBN
cord-021419-nypnib0h	540	20	.	.	.
cord-021419-nypnib0h	541	1	Derivative	derivative	JJ
cord-021419-nypnib0h	541	2	96	96	CD
cord-021419-nypnib0h	541	3	exhibits	exhibit	NNS
cord-021419-nypnib0h	541	4	twice	twice	RB
cord-021419-nypnib0h	541	5	lower	low	JJR
cord-021419-nypnib0h	541	6	activity	activity	NN
cord-021419-nypnib0h	541	7	against	against	IN
cord-021419-nypnib0h	541	8	S.	S.	NNP
cord-021419-nypnib0h	541	9	fradiae	fradiae	NN
cord-021419-nypnib0h	541	10	ATCC-19609	ATCC-19609	NNP
cord-021419-nypnib0h	541	11	compared	compare	VBN
cord-021419-nypnib0h	541	12	to	to	IN
cord-021419-nypnib0h	541	13	com-	com-	NN
cord-021419-nypnib0h	541	14	 	 	_SP
cord-021419-nypnib0h	541	15	pound	pound	NN
cord-021419-nypnib0h	541	16	90a	90a	NNS
cord-021419-nypnib0h	541	17	;	;	:
cord-021419-nypnib0h	541	18	its	-PRON-	PRP$
cord-021419-nypnib0h	541	19	activity	activity	NN
cord-021419-nypnib0h	541	20	against	against	IN
cord-021419-nypnib0h	541	21	Candida	Candida	NNP
cord-021419-nypnib0h	541	22	spp	spp	NNS
cord-021419-nypnib0h	541	23	.	.	.
cord-021419-nypnib0h	542	1	and	and	CC
cord-021419-nypnib0h	542	2	other	other	JJ
cord-021419-nypnib0h	542	3	filamentous	filamentous	JJ
cord-021419-nypnib0h	542	4	fungi	fungus	NNS
cord-021419-nypnib0h	542	5	is	be	VBZ
cord-021419-nypnib0h	542	6	very	very	RB
cord-021419-nypnib0h	542	7	similar	similar	JJ
cord-021419-nypnib0h	542	8	to	to	IN
cord-021419-nypnib0h	542	9	that	that	DT
cord-021419-nypnib0h	542	10	of	of	IN
cord-021419-nypnib0h	542	11	compound	compound	NN
cord-021419-nypnib0h	542	12	90a	90a	NNS
cord-021419-nypnib0h	542	13	.	.	.
cord-021419-nypnib0h	543	1	Docking	docking	NN
cord-021419-nypnib0h	543	2	studies	study	NNS
cord-021419-nypnib0h	543	3	of	of	IN
cord-021419-nypnib0h	543	4	the	the	DT
cord-021419-nypnib0h	543	5	binding	binding	NN
cord-021419-nypnib0h	543	6	of	of	IN
cord-021419-nypnib0h	543	7	derivative	derivative	JJ
cord-021419-nypnib0h	543	8	96	96	CD
cord-021419-nypnib0h	543	9	to	to	IN
cord-021419-nypnib0h	543	10	F	f	NN
cord-021419-nypnib0h	543	11	0	0	CD
cord-021419-nypnib0h	543	12	F	f	NN
cord-021419-nypnib0h	543	13	1	1	CD
cord-021419-nypnib0h	544	1	-ATP	-ATP	:
cord-021419-nypnib0h	545	1	synthase	synthase	NNP
cord-021419-nypnib0h	545	2	also	also	RB
cord-021419-nypnib0h	545	3	showed	show	VBD
cord-021419-nypnib0h	545	4	that	that	IN
cord-021419-nypnib0h	545	5	the	the	DT
cord-021419-nypnib0h	545	6	affinity	affinity	NN
cord-021419-nypnib0h	545	7	for	for	IN
cord-021419-nypnib0h	545	8	the	the	DT
cord-021419-nypnib0h	545	9	enzyme	enzyme	NN
cord-021419-nypnib0h	545	10	decreases	decrease	VBZ
cord-021419-nypnib0h	545	11	compared	compare	VBN
cord-021419-nypnib0h	545	12	to	to	IN
cord-021419-nypnib0h	545	13	the	the	DT
cord-021419-nypnib0h	545	14	starting	start	VBG
cord-021419-nypnib0h	545	15	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	545	16	90a	90a	NNS
cord-021419-nypnib0h	545	17	.	.	.
cord-021419-nypnib0h	546	1	54	54	CD
cord-021419-nypnib0h	547	1	A	a	DT
cord-021419-nypnib0h	547	2	method	method	NN
cord-021419-nypnib0h	547	3	for	for	IN
cord-021419-nypnib0h	547	4	the	the	DT
cord-021419-nypnib0h	547	5	synthesis	synthesis	NN
cord-021419-nypnib0h	547	6	of	of	IN
cord-021419-nypnib0h	547	7	1,4-disubstituted	1,4-disubstituted	CD
cord-021419-nypnib0h	547	8	1,2,3triazoles	1,2,3triazoles	CD
cord-021419-nypnib0h	547	9	of	of	IN
cord-021419-nypnib0h	547	10	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	547	11	was	be	VBD
cord-021419-nypnib0h	547	12	developed	develop	VBN
cord-021419-nypnib0h	547	13	based	base	VBN
cord-021419-nypnib0h	547	14	on	on	IN
cord-021419-nypnib0h	547	15	33-azido-33-deoxyoligomycin	33-azido-33-deoxyoligomycin	CD
cord-021419-nypnib0h	547	16	94	94	CD
cord-021419-nypnib0h	547	17	.	.	.
cord-021419-nypnib0h	548	1	The	the	DT
cord-021419-nypnib0h	548	2	method	method	NN
cord-021419-nypnib0h	548	3	involves	involve	VBZ
cord-021419-nypnib0h	548	4	the	the	DT
cord-021419-nypnib0h	548	5	regioselective	regioselective	NN
cord-021419-nypnib0h	548	6	[	[	-LRB-
cord-021419-nypnib0h	548	7	3	3	CD
cord-021419-nypnib0h	548	8	+	+	SYM
cord-021419-nypnib0h	548	9	2]-dipolar	2]-dipolar	CD
cord-021419-nypnib0h	548	10	cycloaddition	cycloaddition	NN
cord-021419-nypnib0h	548	11	of	of	IN
cord-021419-nypnib0h	548	12	the	the	DT
cord-021419-nypnib0h	548	13	33-azido	33-azido	CD
cord-021419-nypnib0h	548	14	group	group	NN
cord-021419-nypnib0h	548	15	to	to	IN
cord-021419-nypnib0h	548	16	monosubstituted	monosubstituted	JJ
cord-021419-nypnib0h	548	17	alkynes	alkyne	NNS
cord-021419-nypnib0h	548	18	(	(	-LRB-
cord-021419-nypnib0h	548	19	Scheme	scheme	NN
cord-021419-nypnib0h	548	20	26	26	CD
cord-021419-nypnib0h	548	21	)	)	-RRB-
cord-021419-nypnib0h	548	22	.	.	.
cord-021419-nypnib0h	549	1	55	55	CD
cord-021419-nypnib0h	550	1	The	the	DT
cord-021419-nypnib0h	550	2	reaction	reaction	NN
cord-021419-nypnib0h	550	3	of	of	IN
cord-021419-nypnib0h	550	4	azide	azide	NN
cord-021419-nypnib0h	550	5	94	94	CD
cord-021419-nypnib0h	550	6	with	with	IN
cord-021419-nypnib0h	550	7	alkynes	alkyne	NNS
cord-021419-nypnib0h	550	8	(	(	-LRB-
cord-021419-nypnib0h	550	9	phenylacetylene	phenylacetylene	NNP
cord-021419-nypnib0h	550	10	,	,	,
cord-021419-nypnib0h	550	11	propiolic	propiolic	JJ
cord-021419-nypnib0h	550	12	acid	acid	NNP
cord-021419-nypnib0h	550	13	and	and	CC
cord-021419-nypnib0h	550	14	methyl	methyl	NN
cord-021419-nypnib0h	550	15	propiolate	propiolate	NN
cord-021419-nypnib0h	550	16	)	)	-RRB-
cord-021419-nypnib0h	550	17	in	in	IN
cord-021419-nypnib0h	550	18	a	a	DT
cord-021419-nypnib0h	550	19	tert	tert	NN
cord-021419-nypnib0h	550	20	-	-	HYPH
cord-021419-nypnib0h	550	21	butanol	butanol	NN
cord-021419-nypnib0h	550	22	±	±	NNP
cord-021419-nypnib0h	550	23	water	water	NN
cord-021419-nypnib0h	550	24	mixture	mixture	NN
cord-021419-nypnib0h	550	25	(	(	-LRB-
cord-021419-nypnib0h	550	26	1	1	CD
cord-021419-nypnib0h	550	27	:	:	SYM
cord-021419-nypnib0h	550	28	1	1	LS
cord-021419-nypnib0h	550	29	)	)	-RRB-
cord-021419-nypnib0h	550	30	can	can	MD
cord-021419-nypnib0h	550	31	be	be	VB
cord-021419-nypnib0h	550	32	performed	perform	VBN
cord-021419-nypnib0h	550	33	both	both	CC
cord-021419-nypnib0h	550	34	in	in	IN
cord-021419-nypnib0h	550	35	the	the	DT
cord-021419-nypnib0h	550	36	presence	presence	NN
cord-021419-nypnib0h	550	37	of	of	IN
cord-021419-nypnib0h	550	38	a	a	DT
cord-021419-nypnib0h	550	39	catalyst	catalyst	NN
cord-021419-nypnib0h	550	40	(	(	-LRB-
cord-021419-nypnib0h	550	41	Cu	Cu	NNP
cord-021419-nypnib0h	550	42	I	i	NN
cord-021419-nypnib0h	550	43	)	)	-RRB-
cord-021419-nypnib0h	550	44	or	or	CC
cord-021419-nypnib0h	550	45	without	without	IN
cord-021419-nypnib0h	550	46	catalysts	catalyst	NNS
cord-021419-nypnib0h	550	47	.	.	.
cord-021419-nypnib0h	551	1	This	this	DT
cord-021419-nypnib0h	551	2	approach	approach	NN
cord-021419-nypnib0h	551	3	was	be	VBD
cord-021419-nypnib0h	551	4	applied	apply	VBN
cord-021419-nypnib0h	551	5	to	to	TO
cord-021419-nypnib0h	551	6	synthesize	synthesize	VB
cord-021419-nypnib0h	551	7	33-deoxy-33-(4-phenyltriazol-1-yl)oligomycin	33-deoxy-33-(4-phenyltriazol-1-yl)oligomycin	CD
cord-021419-nypnib0h	551	8	(	(	-LRB-
cord-021419-nypnib0h	551	9	97	97	CD
cord-021419-nypnib0h	551	10	)	)	-RRB-
cord-021419-nypnib0h	551	11	,	,	,
cord-021419-nypnib0h	551	12	33-deoxy-33-(4-methoxycarbonyltriazol-1-yl)oligomycin	33-deoxy-33-(4-methoxycarbonyltriazol-1-yl)oligomycin	CD
cord-021419-nypnib0h	551	13	(	(	-LRB-
cord-021419-nypnib0h	551	14	98	98	CD
cord-021419-nypnib0h	551	15	)	)	-RRB-
cord-021419-nypnib0h	551	16	and	and	CC
cord-021419-nypnib0h	551	17	33-deoxy-33-(4-carboxytriazol-1-yl)oligomycin	33-deoxy-33-(4-carboxytriazol-1-yl)oligomycin	NNS
cord-021419-nypnib0h	551	18	(	(	-LRB-
cord-021419-nypnib0h	551	19	99	99	CD
cord-021419-nypnib0h	551	20	)	)	-RRB-
cord-021419-nypnib0h	551	21	in	in	IN
cord-021419-nypnib0h	551	22	53	53	CD
cord-021419-nypnib0h	551	23	%	%	NN
cord-021419-nypnib0h	551	24	,	,	,
cord-021419-nypnib0h	551	25	52	52	CD
cord-021419-nypnib0h	551	26	%	%	NN
cord-021419-nypnib0h	551	27	and	and	CC
cord-021419-nypnib0h	551	28	50	50	CD
cord-021419-nypnib0h	551	29	%	%	NN
cord-021419-nypnib0h	551	30	yields	yield	NNS
cord-021419-nypnib0h	551	31	,	,	,
cord-021419-nypnib0h	551	32	respectively	respectively	RB
cord-021419-nypnib0h	551	33	.	.	.
cord-021419-nypnib0h	552	1	Compound	compound	NN
cord-021419-nypnib0h	552	2	99	99	CD
cord-021419-nypnib0h	552	3	served	serve	VBD
cord-021419-nypnib0h	552	4	as	as	IN
cord-021419-nypnib0h	552	5	the	the	DT
cord-021419-nypnib0h	552	6	starting	starting	NN
cord-021419-nypnib0h	552	7	compound	compound	NN
cord-021419-nypnib0h	552	8	for	for	IN
cord-021419-nypnib0h	552	9	the	the	DT
cord-021419-nypnib0h	552	10	synthesis	synthesis	NN
cord-021419-nypnib0h	552	11	of	of	IN
cord-021419-nypnib0h	552	12	water	water	NN
cord-021419-nypnib0h	552	13	-	-	HYPH
cord-021419-nypnib0h	552	14	soluble	soluble	JJ
cord-021419-nypnib0h	552	15	33-deoxy-33-[(4-DMAE	33-deoxy-33-[(4-dmae	CD
cord-021419-nypnib0h	552	16	-	-	HYPH
cord-021419-nypnib0h	552	17	carbonyl)triazol-1yl]oligomycin	carbonyl)triazol-1yl]oligomycin	NNS
cord-021419-nypnib0h	552	18	amide	amide	NN
cord-021419-nypnib0h	552	19	(	(	-LRB-
cord-021419-nypnib0h	552	20	100	100	CD
cord-021419-nypnib0h	552	21	)	)	-RRB-
cord-021419-nypnib0h	552	22	exhibiting	exhibit	VBG
cord-021419-nypnib0h	552	23	selective	selective	JJ
cord-021419-nypnib0h	552	24	antitumour	antitumour	JJ
cord-021419-nypnib0h	552	25	activity	activity	NN
cord-021419-nypnib0h	552	26	.	.	.
cord-021419-nypnib0h	553	1	55	55	CD
cord-021419-nypnib0h	553	2	 	 	_SP
cord-021419-nypnib0h	554	1	Oligomycin	Oligomycin	NNP
cord-021419-nypnib0h	554	2	90a	90a	NNS
cord-021419-nypnib0h	554	3	undergoes	undergo	VBZ
cord-021419-nypnib0h	554	4	a	a	DT
cord-021419-nypnib0h	554	5	retro	retro	JJ
cord-021419-nypnib0h	554	6	-	-	HYPH
cord-021419-nypnib0h	554	7	aldol	aldol	NN
cord-021419-nypnib0h	554	8	rearrangement	rearrangement	NN
cord-021419-nypnib0h	554	9	accompanied	accompany	VBN
cord-021419-nypnib0h	554	10	by	by	IN
cord-021419-nypnib0h	554	11	dehydration	dehydration	NN
cord-021419-nypnib0h	554	12	in	in	IN
cord-021419-nypnib0h	554	13	the	the	DT
cord-021419-nypnib0h	554	14	presence	presence	NN
cord-021419-nypnib0h	554	15	of	of	IN
cord-021419-nypnib0h	554	16	bases	basis	NNS
cord-021419-nypnib0h	554	17	(	(	-LRB-
cord-021419-nypnib0h	554	18	Scheme	scheme	NN
cord-021419-nypnib0h	554	19	27	27	CD
cord-021419-nypnib0h	554	20	)	)	-RRB-
cord-021419-nypnib0h	554	21	.	.	.
cord-021419-nypnib0h	555	1	60	60	CD
cord-021419-nypnib0h	556	1	The	the	DT
cord-021419-nypnib0h	556	2	structure	structure	NN
cord-021419-nypnib0h	556	3	of	of	IN
cord-021419-nypnib0h	556	4	alkaline	alkaline	JJ
cord-021419-nypnib0h	556	5	degradation	degradation	NN
cord-021419-nypnib0h	556	6	product	product	NN
cord-021419-nypnib0h	556	7	101a	101a	NNS
cord-021419-nypnib0h	556	8	was	be	VBD
cord-021419-nypnib0h	556	9	established	establish	VBN
cord-021419-nypnib0h	556	10	by	by	IN
cord-021419-nypnib0h	556	11	the	the	DT
cord-021419-nypnib0h	556	12	detailed	detailed	JJ
cord-021419-nypnib0h	556	13	1	1	CD
cord-021419-nypnib0h	556	14	H	h	NN
cord-021419-nypnib0h	556	15	and	and	CC
cord-021419-nypnib0h	556	16	13	13	CD
cord-021419-nypnib0h	556	17	C	c	NN
cord-021419-nypnib0h	556	18	NMR	NMR	NNP
cord-021419-nypnib0h	556	19	study	study	NN
cord-021419-nypnib0h	556	20	,	,	,
cord-021419-nypnib0h	556	21	including	include	VBG
cord-021419-nypnib0h	556	22	heteronuclear	heteronuclear	NN
cord-021419-nypnib0h	556	23	correlation	correlation	NN
cord-021419-nypnib0h	556	24	,	,	,
cord-021419-nypnib0h	556	25	combined	combine	VBN
cord-021419-nypnib0h	556	26	with	with	IN
cord-021419-nypnib0h	556	27	tandem	tandem	JJ
cord-021419-nypnib0h	556	28	mass	mass	NN
cord-021419-nypnib0h	556	29	spectrometry	spectrometry	NN
cord-021419-nypnib0h	556	30	(	(	-LRB-
cord-021419-nypnib0h	556	31	ESI	ESI	NNP
cord-021419-nypnib0h	556	32	-	-	HYPH
cord-021419-nypnib0h	556	33	MS	MS	NNP
cord-021419-nypnib0h	556	34	/	/	SYM
cord-021419-nypnib0h	556	35	MS	MS	NNP
cord-021419-nypnib0h	556	36	-	-	HYPH
cord-021419-nypnib0h	556	37	MRM	MRM	NNP
cord-021419-nypnib0h	556	38	)	)	-RRB-
cord-021419-nypnib0h	556	39	.	.	.
cord-021419-nypnib0h	557	1	The	the	DT
cord-021419-nypnib0h	557	2	structure	structure	NN
cord-021419-nypnib0h	557	3	of	of	IN
cord-021419-nypnib0h	557	4	the	the	DT
cord-021419-nypnib0h	557	5	carbon	carbon	NN
cord-021419-nypnib0h	557	6	skeleton	skeleton	NN
cord-021419-nypnib0h	557	7	of	of	IN
cord-021419-nypnib0h	557	8	the	the	DT
cord-021419-nypnib0h	557	9	starting	start	VBG
cord-021419-nypnib0h	557	10	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	557	11	90a	90a	NNS
cord-021419-nypnib0h	557	12	undergoes	undergo	VBZ
cord-021419-nypnib0h	557	13	a	a	DT
cord-021419-nypnib0h	557	14	significant	significant	JJ
cord-021419-nypnib0h	557	15	transformation	transformation	NN
cord-021419-nypnib0h	557	16	at	at	IN
cord-021419-nypnib0h	557	17	C(7)7C(12	C(7)7C(12	NNP
cord-021419-nypnib0h	557	18	)	)	-RRB-
cord-021419-nypnib0h	558	1	(	(	-LRB-
cord-021419-nypnib0h	558	2	the	the	DT
cord-021419-nypnib0h	558	3	cleavage	cleavage	NN
cord-021419-nypnib0h	558	4	pathways	pathway	NNS
cord-021419-nypnib0h	558	5	a	a	DT
cord-021419-nypnib0h	558	6	,	,	,
cord-021419-nypnib0h	558	7	b	b	NN
cord-021419-nypnib0h	558	8	and	and	CC
cord-021419-nypnib0h	558	9	c	c	NN
cord-021419-nypnib0h	558	10	)	)	-RRB-
cord-021419-nypnib0h	559	1	giving	give	VBG
cord-021419-nypnib0h	559	2	open	open	JJ
cord-021419-nypnib0h	559	3	-	-	HYPH
cord-021419-nypnib0h	559	4	ring	ring	NN
cord-021419-nypnib0h	559	5	compound	compound	NN
cord-021419-nypnib0h	559	6	101a	101a	NNS
cord-021419-nypnib0h	559	7	.	.	.
cord-021419-nypnib0h	560	1	The	the	DT
cord-021419-nypnib0h	560	2	mechanism	mechanism	NN
cord-021419-nypnib0h	560	3	of	of	IN
cord-021419-nypnib0h	560	4	alkaline	alkaline	JJ
cord-021419-nypnib0h	560	5	degradation	degradation	NN
cord-021419-nypnib0h	560	6	of	of	IN
cord-021419-nypnib0h	560	7	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	560	8	90a	90a	NNS
cord-021419-nypnib0h	560	9	presented	present	VBN
cord-021419-nypnib0h	560	10	in	in	IN
cord-021419-nypnib0h	560	11	Scheme	Scheme	NNP
cord-021419-nypnib0h	560	12	27	27	CD
cord-021419-nypnib0h	560	13	accounts	account	NNS
cord-021419-nypnib0h	560	14	for	for	IN
cord-021419-nypnib0h	560	15	the	the	DT
cord-021419-nypnib0h	560	16	formation	formation	NN
cord-021419-nypnib0h	560	17	of	of	IN
cord-021419-nypnib0h	560	18	derivative	derivative	JJ
cord-021419-nypnib0h	560	19	101a	101a	NNS
cord-021419-nypnib0h	560	20	(	(	-LRB-
cord-021419-nypnib0h	560	21	through	through	IN
cord-021419-nypnib0h	560	22	intermediates	intermediate	NNS
cord-021419-nypnib0h	560	23	90c	90c	NNPS
cord-021419-nypnib0h	560	24	,	,	,
cord-021419-nypnib0h	560	25	d	d	NN
cord-021419-nypnib0h	560	26	)	)	-RRB-
cord-021419-nypnib0h	560	27	but	but	CC
cord-021419-nypnib0h	560	28	not	not	RB
cord-021419-nypnib0h	560	29	for	for	IN
cord-021419-nypnib0h	560	30	the	the	DT
cord-021419-nypnib0h	560	31	formation	formation	NN
cord-021419-nypnib0h	560	32	of	of	IN
cord-021419-nypnib0h	560	33	101b	101b	NNP
cord-021419-nypnib0h	560	34	(	(	-LRB-
cord-021419-nypnib0h	560	35	through	through	IN
cord-021419-nypnib0h	560	36	intermediates	intermediate	NNS
cord-021419-nypnib0h	560	37	90e	90e	NNPS
cord-021419-nypnib0h	560	38	,	,	,
cord-021419-nypnib0h	560	39	f	f	NNP
cord-021419-nypnib0h	560	40	)	)	-RRB-
cord-021419-nypnib0h	560	41	.	.	.
cord-021419-nypnib0h	561	1	61	61	CD
cord-021419-nypnib0h	562	1	As	as	IN
cord-021419-nypnib0h	562	2	opposed	oppose	VBN
cord-021419-nypnib0h	562	3	to	to	IN
cord-021419-nypnib0h	562	4	compound	compound	NN
cord-021419-nypnib0h	562	5	90a	90a	NNS
cord-021419-nypnib0h	562	6	,	,	,
cord-021419-nypnib0h	562	7	compound	compound	NN
cord-021419-nypnib0h	562	8	101a	101a	NNS
cord-021419-nypnib0h	562	9	does	do	VBZ
cord-021419-nypnib0h	562	10	not	not	RB
cord-021419-nypnib0h	562	11	exhibit	exhibit	VB
cord-021419-nypnib0h	562	12	activity	activity	NN
cord-021419-nypnib0h	562	13	against	against	IN
cord-021419-nypnib0h	562	14	proteasomal	proteasomal	NNP
cord-021419-nypnib0h	562	15	F	F	NNP
cord-021419-nypnib0h	562	16	0	0	CD
cord-021419-nypnib0h	562	17	F	f	NN
cord-021419-nypnib0h	562	18	1	1	CD
cord-021419-nypnib0h	563	1	-ATP	-ATP	:
cord-021419-nypnib0h	564	1	synthase	synthase	NN
cord-021419-nypnib0h	564	2	at	at	IN
cord-021419-nypnib0h	564	3	a	a	DT
cord-021419-nypnib0h	564	4	concentration	concentration	NN
cord-021419-nypnib0h	564	5	of	of	IN
cord-021419-nypnib0h	564	6	1	1	CD
cord-021419-nypnib0h	564	7	mmol	mmol	NN
cord-021419-nypnib0h	564	8	L	L	NNP
cord-021419-nypnib0h	564	9	71	71	CD
cord-021419-nypnib0h	564	10	because	because	IN
cord-021419-nypnib0h	564	11	of	of	IN
cord-021419-nypnib0h	564	12	the	the	DT
cord-021419-nypnib0h	564	13	loss	loss	NN
cord-021419-nypnib0h	564	14	of	of	IN
cord-021419-nypnib0h	564	15	conformational	conformational	JJ
cord-021419-nypnib0h	564	16	rigidity	rigidity	NN
cord-021419-nypnib0h	564	17	.	.	.
cord-021419-nypnib0h	565	1	The	the	DT
cord-021419-nypnib0h	565	2	hydrogenation	hydrogenation	NN
cord-021419-nypnib0h	565	3	of	of	IN
cord-021419-nypnib0h	565	4	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	565	5	(	(	-LRB-
cord-021419-nypnib0h	565	6	90a	90a	NNS
cord-021419-nypnib0h	565	7	)	)	-RRB-
cord-021419-nypnib0h	565	8	on	on	IN
cord-021419-nypnib0h	565	9	a	a	DT
cord-021419-nypnib0h	565	10	palladium	palladium	NN
cord-021419-nypnib0h	565	11	catalyst	catalyst	NN
cord-021419-nypnib0h	565	12	occurs	occur	VBZ
cord-021419-nypnib0h	565	13	both	both	CC
cord-021419-nypnib0h	565	14	at	at	IN
cord-021419-nypnib0h	565	15	the	the	DT
cord-021419-nypnib0h	565	16	2,3-unsaturated	2,3-unsaturated	CD
cord-021419-nypnib0h	565	17	bond	bond	NN
cord-021419-nypnib0h	565	18	of	of	IN
cord-021419-nypnib0h	565	19	lactone	lactone	NN
cord-021419-nypnib0h	565	20	and	and	CC
cord-021419-nypnib0h	565	21	the	the	DT
cord-021419-nypnib0h	565	22	diene	diene	NN
cord-021419-nypnib0h	565	23	system	system	NN
cord-021419-nypnib0h	565	24	at	at	IN
cord-021419-nypnib0h	565	25	C	C	NNP
cord-021419-nypnib0h	565	26	(	(	-LRB-
cord-021419-nypnib0h	565	27	16	16	CD
cord-021419-nypnib0h	565	28	)	)	-RRB-
cord-021419-nypnib0h	566	1	The	the	DT
cord-021419-nypnib0h	566	2	hydrogenation	hydrogenation	NN
cord-021419-nypnib0h	566	3	of	of	IN
cord-021419-nypnib0h	566	4	compound	compound	NN
cord-021419-nypnib0h	566	5	90a	90a	NNS
cord-021419-nypnib0h	566	6	under	under	IN
cord-021419-nypnib0h	566	7	other	other	JJ
cord-021419-nypnib0h	566	8	conditions	condition	NNS
cord-021419-nypnib0h	566	9	leads	lead	VBZ
cord-021419-nypnib0h	566	10	to	to	IN
cord-021419-nypnib0h	566	11	the	the	DT
cord-021419-nypnib0h	566	12	sequential	sequential	JJ
cord-021419-nypnib0h	566	13	selective	selective	JJ
cord-021419-nypnib0h	566	14	reduction	reduction	NN
cord-021419-nypnib0h	566	15	of	of	IN
cord-021419-nypnib0h	566	16	keto	keto	NNP
cord-021419-nypnib0h	566	17	groups	group	NNS
cord-021419-nypnib0h	566	18	Ð	Ð	NNP
cord-021419-nypnib0h	566	19	first	first	RB
cord-021419-nypnib0h	566	20	at	at	IN
cord-021419-nypnib0h	566	21	the	the	DT
cord-021419-nypnib0h	566	22	C(7	C(7	NNP
cord-021419-nypnib0h	566	23	)	)	-RRB-
cord-021419-nypnib0h	566	24	atom	atom	NN
cord-021419-nypnib0h	566	25	and	and	CC
cord-021419-nypnib0h	566	26	then	then	RB
cord-021419-nypnib0h	566	27	at	at	IN
cord-021419-nypnib0h	566	28	the	the	DT
cord-021419-nypnib0h	566	29	C(11	C(11	NNP
cord-021419-nypnib0h	566	30	)	)	-RRB-
cord-021419-nypnib0h	566	31	atom	atom	NN
cord-021419-nypnib0h	566	32	.	.	.
cord-021419-nypnib0h	567	1	Thus	thus	RB
cord-021419-nypnib0h	567	2	,	,	,
cord-021419-nypnib0h	567	3	the	the	DT
cord-021419-nypnib0h	567	4	use	use	NN
cord-021419-nypnib0h	567	5	of	of	IN
cord-021419-nypnib0h	567	6	NaBH(OAc	NaBH(OAc	NNP
cord-021419-nypnib0h	567	7	)	)	-RRB-
cord-021419-nypnib0h	567	8	3	3	CD
cord-021419-nypnib0h	567	9	latter	latter	RB
cord-021419-nypnib0h	567	10	with	with	IN
cord-021419-nypnib0h	567	11	NaBH	NaBH	NNP
cord-021419-nypnib0h	567	12	4	4	CD
cord-021419-nypnib0h	567	13	in	in	IN
cord-021419-nypnib0h	567	14	ethanol	ethanol	NN
cord-021419-nypnib0h	567	15	afforded	afford	VBN
cord-021419-nypnib0h	567	16	(	(	-LRB-
cord-021419-nypnib0h	567	17	7S,11R)-tetrahydrooligomycin	7s,11r)-tetrahydrooligomycin	JJ
cord-021419-nypnib0h	567	18	(	(	-LRB-
cord-021419-nypnib0h	567	19	104	104	CD
cord-021419-nypnib0h	567	20	)	)	-RRB-
cord-021419-nypnib0h	567	21	(	(	-LRB-
cord-021419-nypnib0h	567	22	see	see	VB
cord-021419-nypnib0h	567	23	Scheme	Scheme	NNP
cord-021419-nypnib0h	567	24	28	28	CD
cord-021419-nypnib0h	567	25	)	)	-RRB-
cord-021419-nypnib0h	567	26	.	.	.
cord-021419-nypnib0h	568	1	59	59	CD
cord-021419-nypnib0h	569	1	The	the	DT
cord-021419-nypnib0h	569	2	hydrogenation	hydrogenation	NN
cord-021419-nypnib0h	569	3	of	of	IN
cord-021419-nypnib0h	569	4	double	double	JJ
cord-021419-nypnib0h	569	5	bonds	bond	NNS
cord-021419-nypnib0h	569	6	of	of	IN
cord-021419-nypnib0h	569	7	the	the	DT
cord-021419-nypnib0h	569	8	macrolactone	macrolactone	NN
cord-021419-nypnib0h	569	9	ring	ring	NN
cord-021419-nypnib0h	569	10	causes	cause	VBZ
cord-021419-nypnib0h	569	11	a	a	DT
cord-021419-nypnib0h	569	12	decrease	decrease	NN
cord-021419-nypnib0h	569	13	in	in	IN
cord-021419-nypnib0h	569	14	the	the	DT
cord-021419-nypnib0h	569	15	activity	activity	NN
cord-021419-nypnib0h	569	16	of	of	IN
cord-021419-nypnib0h	569	17	compound	compound	NN
cord-021419-nypnib0h	569	18	90a	90a	NNS
cord-021419-nypnib0h	569	19	both	both	CC
cord-021419-nypnib0h	569	20	against	against	IN
cord-021419-nypnib0h	569	21	actinobacteria	actinobacteria	NNP
cord-021419-nypnib0h	569	22	and	and	CC
cord-021419-nypnib0h	569	23	fungal	fungal	JJ
cord-021419-nypnib0h	569	24	and	and	CC
cord-021419-nypnib0h	569	25	mammalian	mammalian	JJ
cord-021419-nypnib0h	569	26	cells	cell	NNS
cord-021419-nypnib0h	569	27	.	.	.
cord-021419-nypnib0h	570	1	62	62	CD
cord-021419-nypnib0h	571	1	This	this	DT
cord-021419-nypnib0h	571	2	may	may	MD
cord-021419-nypnib0h	571	3	be	be	VB
cord-021419-nypnib0h	571	4	attributed	attribute	VBN
cord-021419-nypnib0h	571	5	to	to	IN
cord-021419-nypnib0h	571	6	the	the	DT
cord-021419-nypnib0h	571	7	loss	loss	NN
cord-021419-nypnib0h	571	8	of	of	IN
cord-021419-nypnib0h	571	9	conformational	conformational	JJ
cord-021419-nypnib0h	571	10	rigidity	rigidity	NN
cord-021419-nypnib0h	571	11	and	and	CC
cord-021419-nypnib0h	571	12	the	the	DT
cord-021419-nypnib0h	571	13	fact	fact	NN
cord-021419-nypnib0h	571	14	that	that	IN
cord-021419-nypnib0h	571	15	the	the	DT
cord-021419-nypnib0h	571	16	geometry	geometry	NN
cord-021419-nypnib0h	571	17	of	of	IN
cord-021419-nypnib0h	571	18	the	the	DT
cord-021419-nypnib0h	571	19	macrocycle	macrocycle	FW
cord-021419-nypnib0h	571	20	favourable	favourable	JJ
cord-021419-nypnib0h	571	21	for	for	IN
cord-021419-nypnib0h	571	22	the	the	DT
cord-021419-nypnib0h	571	23	interaction	interaction	NN
cord-021419-nypnib0h	571	24	with	with	IN
cord-021419-nypnib0h	571	25	the	the	DT
cord-021419-nypnib0h	571	26	target	target	NN
cord-021419-nypnib0h	571	27	(	(	-LRB-
cord-021419-nypnib0h	571	28	F	f	NN
cord-021419-nypnib0h	571	29	0	0	CD
cord-021419-nypnib0h	571	30	F	F	NNP
cord-021419-nypnib0h	571	31	1	1	CD
cord-021419-nypnib0h	571	32	-ATP	-ATP	:
cord-021419-nypnib0h	571	33	synthase	synthase	NNP
cord-021419-nypnib0h	571	34	)	)	-RRB-
cord-021419-nypnib0h	571	35	is	be	VBZ
cord-021419-nypnib0h	571	36	changed	change	VBN
cord-021419-nypnib0h	571	37	because	because	IN
cord-021419-nypnib0h	571	38	of	of	IN
cord-021419-nypnib0h	571	39	destruction	destruction	NN
cord-021419-nypnib0h	571	40	of	of	IN
cord-021419-nypnib0h	571	41	the	the	DT
cord-021419-nypnib0h	571	42	diene	diene	NN
cord-021419-nypnib0h	571	43	system	system	NN
cord-021419-nypnib0h	571	44	of	of	IN
cord-021419-nypnib0h	571	45	the	the	DT
cord-021419-nypnib0h	571	46	starting	start	VBG
cord-021419-nypnib0h	571	47	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	571	48	90a	90a	NNS
cord-021419-nypnib0h	571	49	.	.	.
cord-021419-nypnib0h	572	1	The	the	DT
cord-021419-nypnib0h	572	2	retention	retention	NN
cord-021419-nypnib0h	572	3	of	of	IN
cord-021419-nypnib0h	572	4	activity	activity	NN
cord-021419-nypnib0h	572	5	of	of	IN
cord-021419-nypnib0h	572	6	the	the	DT
cord-021419-nypnib0h	572	7	starting	starting	NN
cord-021419-nypnib0h	572	8	compound	compound	NN
cord-021419-nypnib0h	572	9	102	102	CD
cord-021419-nypnib0h	572	10	against	against	IN
cord-021419-nypnib0h	572	11	some	some	DT
cord-021419-nypnib0h	572	12	strains	strain	NNS
cord-021419-nypnib0h	572	13	of	of	IN
cord-021419-nypnib0h	572	14	Candida	Candida	NNP
cord-021419-nypnib0h	572	15	spp	spp	NNS
cord-021419-nypnib0h	572	16	.	.	.
cord-021419-nypnib0h	573	1	supports	support	VBZ
cord-021419-nypnib0h	573	2	the	the	DT
cord-021419-nypnib0h	573	3	previous	previous	JJ
cord-021419-nypnib0h	573	4	suggestion	suggestion	NN
cord-021419-nypnib0h	573	5	that	that	IN
cord-021419-nypnib0h	573	6	there	there	EX
cord-021419-nypnib0h	573	7	are	be	VBP
cord-021419-nypnib0h	573	8	additional	additional	JJ
cord-021419-nypnib0h	573	9	targets	target	NNS
cord-021419-nypnib0h	573	10	in	in	IN
cord-021419-nypnib0h	573	11	yeast	yeast	NN
cord-021419-nypnib0h	573	12	cells	cell	NNS
cord-021419-nypnib0h	573	13	of	of	IN
cord-021419-nypnib0h	573	14	this	this	DT
cord-021419-nypnib0h	573	15	genus	genus	NN
cord-021419-nypnib0h	573	16	,	,	,
cord-021419-nypnib0h	573	17	the	the	DT
cord-021419-nypnib0h	573	18	binding	binding	NN
cord-021419-nypnib0h	573	19	to	to	TO
cord-021419-nypnib0h	573	20	which	which	WDT
cord-021419-nypnib0h	573	21	is	be	VBZ
cord-021419-nypnib0h	573	22	apparently	apparently	RB
cord-021419-nypnib0h	573	23	independent	independent	JJ
cord-021419-nypnib0h	573	24	of	of	IN
cord-021419-nypnib0h	573	25	the	the	DT
cord-021419-nypnib0h	573	26	geometry	geometry	NN
cord-021419-nypnib0h	573	27	of	of	IN
cord-021419-nypnib0h	573	28	the	the	DT
cord-021419-nypnib0h	573	29	macrocycle	macrocycle	NNP
cord-021419-nypnib0h	573	30	.	.	.
cord-021419-nypnib0h	574	1	The	the	DT
cord-021419-nypnib0h	574	2	reaction	reaction	NN
cord-021419-nypnib0h	574	3	of	of	IN
cord-021419-nypnib0h	574	4	compound	compound	NN
cord-021419-nypnib0h	574	5	90a	90a	NNS
cord-021419-nypnib0h	574	6	with	with	IN
cord-021419-nypnib0h	574	7	m	m	NNP
cord-021419-nypnib0h	574	8	-	-	HYPH
cord-021419-nypnib0h	574	9	chloroperoxybenzoic	chloroperoxybenzoic	NNP
cord-021419-nypnib0h	574	10	acid	acid	NN
cord-021419-nypnib0h	574	11	(	(	-LRB-
cord-021419-nypnib0h	574	12	m	m	NNP
cord-021419-nypnib0h	574	13	-	-	HYPH
cord-021419-nypnib0h	574	14	CPBA	CPBA	NNP
cord-021419-nypnib0h	574	15	)	)	-RRB-
cord-021419-nypnib0h	574	16	in	in	IN
cord-021419-nypnib0h	574	17	dichloromethane	dichloromethane	NNP
cord-021419-nypnib0h	574	18	on	on	IN
cord-021419-nypnib0h	574	19	decreasing	decrease	VBG
cord-021419-nypnib0h	574	20	the	the	DT
cord-021419-nypnib0h	574	21	reaction	reaction	NN
cord-021419-nypnib0h	574	22	temperature	temperature	NN
cord-021419-nypnib0h	574	23	to	to	IN
cord-021419-nypnib0h	574	24	717	717	CD
cord-021419-nypnib0h	574	25	8C	8c	CD
cord-021419-nypnib0h	574	26	allows	allow	VBZ
cord-021419-nypnib0h	574	27	the	the	DT
cord-021419-nypnib0h	574	28	selective	selective	JJ
cord-021419-nypnib0h	574	29	epoxidation	epoxidation	NN
cord-021419-nypnib0h	574	30	of	of	IN
cord-021419-nypnib0h	574	31	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	574	32	at	at	IN
cord-021419-nypnib0h	574	33	one	one	CD
cord-021419-nypnib0h	574	34	of	of	IN
cord-021419-nypnib0h	574	35	C	c	NN
cord-021419-nypnib0h	574	36	=	=	SYM
cord-021419-nypnib0h	574	37	C	c	NN
cord-021419-nypnib0h	574	38	bonds	bond	NNS
cord-021419-nypnib0h	574	39	to	to	TO
cord-021419-nypnib0h	574	40	form	form	VB
cord-021419-nypnib0h	574	41	unstable	unstable	JJ
cord-021419-nypnib0h	574	42	intermediate	intermediate	JJ
cord-021419-nypnib0h	574	43	epoxide	epoxide	NN
cord-021419-nypnib0h	574	44	105	105	CD
cord-021419-nypnib0h	574	45	(	(	-LRB-
cord-021419-nypnib0h	574	46	Scheme	scheme	NN
cord-021419-nypnib0h	574	47	29	29	CD
cord-021419-nypnib0h	574	48	)	)	-RRB-
cord-021419-nypnib0h	574	49	.	.	.
cord-021419-nypnib0h	575	1	59	59	CD
cord-021419-nypnib0h	576	1	In	in	IN
cord-021419-nypnib0h	576	2	the	the	DT
cord-021419-nypnib0h	576	3	presence	presence	NN
cord-021419-nypnib0h	576	4	of	of	IN
cord-021419-nypnib0h	576	5	formic	formic	JJ
cord-021419-nypnib0h	576	6	acid	acid	NN
cord-021419-nypnib0h	576	7	,	,	,
cord-021419-nypnib0h	576	8	the	the	DT
cord-021419-nypnib0h	576	9	latter	latter	JJ
cord-021419-nypnib0h	576	10	compound	compound	NN
cord-021419-nypnib0h	576	11	gives	give	VBZ
cord-021419-nypnib0h	576	12	a	a	DT
cord-021419-nypnib0h	576	13	stable	stable	JJ
cord-021419-nypnib0h	576	14	disubstituted	disubstituted	JJ
cord-021419-nypnib0h	576	15	oligomycin	oligomycin	NN
cord-021419-nypnib0h	576	16	derivative	derivative	JJ
cord-021419-nypnib0h	576	17	Ð	Ð	NNP
cord-021419-nypnib0h	576	18	16,17-dihydro-16S,17S	16,17-dihydro-16S,17S	NNP
cord-021419-nypnib0h	576	19	-	-	HYPH
cord-021419-nypnib0h	576	20	dihydroxy-16,33-diformyloligomycin	dihydroxy-16,33-diformyloligomycin	NNP
cord-021419-nypnib0h	576	21	(	(	-LRB-
cord-021419-nypnib0h	576	22	106	106	CD
cord-021419-nypnib0h	576	23	)	)	-RRB-
cord-021419-nypnib0h	576	24	.	.	.
cord-021419-nypnib0h	577	1	Previously	previously	RB
cord-021419-nypnib0h	577	2	,	,	,
cord-021419-nypnib0h	577	3	16-bromo	16-bromo	CD
cord-021419-nypnib0h	577	4	derivative	derivative	JJ
cord-021419-nypnib0h	577	5	107	107	CD
cord-021419-nypnib0h	577	6	of	of	IN
cord-021419-nypnib0h	577	7	this	this	DT
cord-021419-nypnib0h	577	8	antibiotic	antibiotic	NN
cord-021419-nypnib0h	577	9	was	be	VBD
cord-021419-nypnib0h	577	10	synthesized	synthesize	VBN
cord-021419-nypnib0h	577	11	using	use	VBG
cord-021419-nypnib0h	577	12	N	N	NNP
cord-021419-nypnib0h	577	13	-	-	HYPH
cord-021419-nypnib0h	577	14	bromosuccinimide	bromosuccinimide	NNP
cord-021419-nypnib0h	577	15	as	as	IN
cord-021419-nypnib0h	577	16	the	the	DT
cord-021419-nypnib0h	577	17	brominating	brominating	NN
cord-021419-nypnib0h	577	18	agent	agent	NN
cord-021419-nypnib0h	577	19	(	(	-LRB-
cord-021419-nypnib0h	577	20	see	see	VB
cord-021419-nypnib0h	577	21	Scheme	Scheme	NNP
cord-021419-nypnib0h	577	22	29	29	CD
cord-021419-nypnib0h	577	23	)	)	-RRB-
cord-021419-nypnib0h	577	24	.	.	.
cord-021419-nypnib0h	578	1	63	63	CD
cord-021419-nypnib0h	578	2	 	 	_SP
cord-021419-nypnib0h	579	1	The	the	DT
cord-021419-nypnib0h	579	2	addition	addition	NN
cord-021419-nypnib0h	579	3	of	of	IN
cord-021419-nypnib0h	579	4	hydroxylamine	hydroxylamine	NN
cord-021419-nypnib0h	579	5	and	and	CC
cord-021419-nypnib0h	579	6	related	related	JJ
cord-021419-nypnib0h	579	7	compounds	compound	NNS
cord-021419-nypnib0h	579	8	to	to	IN
cord-021419-nypnib0h	579	9	90a	90a	NNS
cord-021419-nypnib0h	579	10	was	be	VBD
cord-021419-nypnib0h	579	11	studied	study	VBN
cord-021419-nypnib0h	579	12	.	.	.
cord-021419-nypnib0h	580	1	64	64	CD
cord-021419-nypnib0h	581	1	The	the	DT
cord-021419-nypnib0h	581	2	comprehensive	comprehensive	JJ
cord-021419-nypnib0h	581	3	study	study	NN
cord-021419-nypnib0h	581	4	of	of	IN
cord-021419-nypnib0h	581	5	the	the	DT
cord-021419-nypnib0h	581	6	resulting	result	VBG
cord-021419-nypnib0h	581	7	compound	compound	NN
cord-021419-nypnib0h	581	8	by	by	IN
cord-021419-nypnib0h	581	9	1	1	CD
cord-021419-nypnib0h	581	10	H	h	NN
cord-021419-nypnib0h	581	11	and	and	CC
cord-021419-nypnib0h	581	12	13	13	CD
cord-021419-nypnib0h	581	13	C	c	NN
cord-021419-nypnib0h	581	14	NMR	nmr	NN
cord-021419-nypnib0h	581	15	spectroscopy	spectroscopy	NN
cord-021419-nypnib0h	581	16	,	,	,
cord-021419-nypnib0h	581	17	including	include	VBG
cord-021419-nypnib0h	581	18	heteronuclear	heteronuclear	NN
cord-021419-nypnib0h	581	19	correlation	correlation	NN
cord-021419-nypnib0h	581	20	,	,	,
cord-021419-nypnib0h	581	21	made	make	VBD
cord-021419-nypnib0h	581	22	it	-PRON-	PRP
cord-021419-nypnib0h	581	23	possible	possible	JJ
cord-021419-nypnib0h	581	24	to	to	TO
cord-021419-nypnib0h	581	25	establish	establish	VB
cord-021419-nypnib0h	581	26	the	the	DT
cord-021419-nypnib0h	581	27	structure	structure	NN
cord-021419-nypnib0h	581	28	of	of	IN
cord-021419-nypnib0h	581	29	nitrone	nitrone	NN
cord-021419-nypnib0h	581	30	108a	108a	NNPS
cord-021419-nypnib0h	581	31	and	and	CC
cord-021419-nypnib0h	581	32	exclude	exclude	VB
cord-021419-nypnib0h	581	33	the	the	DT
cord-021419-nypnib0h	581	34	possible	possible	JJ
cord-021419-nypnib0h	581	35	existence	existence	NN
cord-021419-nypnib0h	581	36	of	of	IN
cord-021419-nypnib0h	581	37	isomer	isomer	NNP
cord-021419-nypnib0h	581	38	108b	108b	CD
cord-021419-nypnib0h	581	39	.	.	.
cord-021419-nypnib0h	582	1	It	-PRON-	PRP
cord-021419-nypnib0h	582	2	was	be	VBD
cord-021419-nypnib0h	582	3	found	find	VBN
cord-021419-nypnib0h	582	4	that	that	IN
cord-021419-nypnib0h	582	5	an	an	DT
cord-021419-nypnib0h	582	6	additional	additional	JJ
cord-021419-nypnib0h	582	7	ring	ring	NN
cord-021419-nypnib0h	582	8	involving	involve	VBG
cord-021419-nypnib0h	582	9	the	the	DT
cord-021419-nypnib0h	582	10	C(3	C(3	NNP
cord-021419-nypnib0h	582	11	)	)	-RRB-
cord-021419-nypnib0h	582	12	±	±	NNP
cord-021419-nypnib0h	582	13	C(7	C(7	NNP
cord-021419-nypnib0h	582	14	)	)	-RRB-
cord-021419-nypnib0h	582	15	atoms	atom	NNS
cord-021419-nypnib0h	582	16	is	be	VBZ
cord-021419-nypnib0h	582	17	formed	form	VBN
cord-021419-nypnib0h	582	18	,	,	,
cord-021419-nypnib0h	582	19	the	the	DT
cord-021419-nypnib0h	582	20	activity	activity	NN
cord-021419-nypnib0h	582	21	of	of	IN
cord-021419-nypnib0h	582	22	the	the	DT
cord-021419-nypnib0h	582	23	antibiotic	antibiotic	NN
cord-021419-nypnib0h	582	24	against	against	IN
cord-021419-nypnib0h	582	25	F	F	NNP
cord-021419-nypnib0h	582	26	0	0	CD
cord-021419-nypnib0h	582	27	F	f	NN
cord-021419-nypnib0h	582	28	1	1	CD
cord-021419-nypnib0h	583	1	-ATP	-ATP	:
cord-021419-nypnib0h	584	1	synthase	synthase	NN
cord-021419-nypnib0h	584	2	being	be	VBG
cord-021419-nypnib0h	584	3	reduced	reduce	VBN
cord-021419-nypnib0h	584	4	.	.	.
cord-021419-nypnib0h	584	5	 	 	_SP
cord-021419-nypnib0h	585	1	The	the	DT
cord-021419-nypnib0h	585	2	reaction	reaction	NN
cord-021419-nypnib0h	585	3	of	of	IN
cord-021419-nypnib0h	585	4	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	585	5	90a	90a	NNS
cord-021419-nypnib0h	585	6	with	with	IN
cord-021419-nypnib0h	585	7	aminopyridinium	aminopyridinium	NN
cord-021419-nypnib0h	585	8	and	and	CC
cord-021419-nypnib0h	585	9	4-dimethylaminopyridinium	4-dimethylaminopyridinium	CD
cord-021419-nypnib0h	585	10	iodides	iodide	NNS
cord-021419-nypnib0h	585	11	in	in	IN
cord-021419-nypnib0h	585	12	pyridine	pyridine	NN
cord-021419-nypnib0h	585	13	affords	afford	VBZ
cord-021419-nypnib0h	585	14	cyclic	cyclic	JJ
cord-021419-nypnib0h	585	15	derivatives	derivative	NNS
cord-021419-nypnib0h	585	16	of	of	IN
cord-021419-nypnib0h	585	17	pyrazolo	pyrazolo	NNP
cord-021419-nypnib0h	585	18	[	[	-LRB-
cord-021419-nypnib0h	585	19	1,5-a	1,5-a	LS
cord-021419-nypnib0h	585	20	]	]	-RRB-
cord-021419-nypnib0h	585	21	pyridine	pyridine	NN
cord-021419-nypnib0h	585	22	and	and	CC
cord-021419-nypnib0h	585	23	4-methylpyrazolo[1,5-a]pyridine	4-methylpyrazolo[1,5-a]pyridine	CD
cord-021419-nypnib0h	585	24	109a	109a	CD
cord-021419-nypnib0h	585	25	,	,	,
cord-021419-nypnib0h	585	26	b	b	NN
cord-021419-nypnib0h	585	27	,	,	,
cord-021419-nypnib0h	585	28	respectively	respectively	RB
cord-021419-nypnib0h	585	29	,	,	,
cord-021419-nypnib0h	585	30	annulated	annulate	VBN
cord-021419-nypnib0h	585	31	to	to	IN
cord-021419-nypnib0h	585	32	the	the	DT
cord-021419-nypnib0h	585	33	macrocycle	macrocycle	FW
cord-021419-nypnib0h	585	34	(	(	-LRB-
cord-021419-nypnib0h	585	35	see	see	VB
cord-021419-nypnib0h	585	36	Scheme	Scheme	NNP
cord-021419-nypnib0h	585	37	30	30	CD
cord-021419-nypnib0h	585	38	)	)	-RRB-
cord-021419-nypnib0h	585	39	.	.	.
cord-021419-nypnib0h	586	1	64	64	CD
cord-021419-nypnib0h	587	1	Their	-PRON-	PRP$
cord-021419-nypnib0h	587	2	structures	structure	NNS
cord-021419-nypnib0h	587	3	were	be	VBD
cord-021419-nypnib0h	587	4	established	establish	VBN
cord-021419-nypnib0h	587	5	by	by	IN
cord-021419-nypnib0h	587	6	1	1	CD
cord-021419-nypnib0h	587	7	H	h	NN
cord-021419-nypnib0h	587	8	and	and	CC
cord-021419-nypnib0h	587	9	13	13	CD
cord-021419-nypnib0h	587	10	C	c	NN
cord-021419-nypnib0h	587	11	NMR	nmr	NN
cord-021419-nypnib0h	587	12	spectroscopy	spectroscopy	NN
cord-021419-nypnib0h	587	13	,	,	,
cord-021419-nypnib0h	587	14	including	include	VBG
cord-021419-nypnib0h	587	15	heteronuclear	heteronuclear	NN
cord-021419-nypnib0h	587	16	correlation	correlation	NN
cord-021419-nypnib0h	587	17	,	,	,
cord-021419-nypnib0h	587	18	and	and	CC
cord-021419-nypnib0h	587	19	structure	structure	NN
cord-021419-nypnib0h	587	20	109c	109c	CD
cord-021419-nypnib0h	587	21	was	be	VBD
cord-021419-nypnib0h	587	22	excluded	exclude	VBN
cord-021419-nypnib0h	587	23	.	.	.
cord-021419-nypnib0h	588	1	Biological	biological	JJ
cord-021419-nypnib0h	588	2	assays	assay	NNS
cord-021419-nypnib0h	588	3	of	of	IN
cord-021419-nypnib0h	588	4	new	new	JJ
cord-021419-nypnib0h	588	5	derivatives	derivative	NNS
cord-021419-nypnib0h	588	6	of	of	IN
cord-021419-nypnib0h	588	7	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	588	8	(	(	-LRB-
cord-021419-nypnib0h	588	9	90a	90a	NNS
cord-021419-nypnib0h	588	10	)	)	-RRB-
cord-021419-nypnib0h	588	11	demonstrated	demonstrate	VBD
cord-021419-nypnib0h	588	12	that	that	IN
cord-021419-nypnib0h	588	13	,	,	,
cord-021419-nypnib0h	588	14	in	in	IN
cord-021419-nypnib0h	588	15	most	most	JJS
cord-021419-nypnib0h	588	16	cases	case	NNS
cord-021419-nypnib0h	588	17	,	,	,
cord-021419-nypnib0h	588	18	modifications	modification	NNS
cord-021419-nypnib0h	588	19	reduce	reduce	VBP
cord-021419-nypnib0h	588	20	biological	biological	JJ
cord-021419-nypnib0h	588	21	activity	activity	NN
cord-021419-nypnib0h	588	22	of	of	IN
cord-021419-nypnib0h	588	23	the	the	DT
cord-021419-nypnib0h	588	24	starting	start	VBG
cord-021419-nypnib0h	588	25	antibiotic	antibiotic	NN
cord-021419-nypnib0h	588	26	against	against	IN
cord-021419-nypnib0h	588	27	S.	S.	NNP
cord-021419-nypnib0h	588	28	fradiae	fradiae	NNP
cord-021419-nypnib0h	588	29	.	.	.
cord-021419-nypnib0h	589	1	54	54	CD
cord-021419-nypnib0h	589	2	,	,	,
cord-021419-nypnib0h	589	3	65	65	CD
cord-021419-nypnib0h	589	4	±	±	CD
cord-021419-nypnib0h	589	5	67	67	CD
cord-021419-nypnib0h	590	1	The	the	DT
cord-021419-nypnib0h	590	2	growth	growth	NN
cord-021419-nypnib0h	590	3	inhibition	inhibition	NN
cord-021419-nypnib0h	590	4	assay	assay	NN
cord-021419-nypnib0h	590	5	of	of	IN
cord-021419-nypnib0h	590	6	the	the	DT
cord-021419-nypnib0h	590	7	strain	strain	NN
cord-021419-nypnib0h	590	8	S.	S.	NNP
cord-021419-nypnib0h	590	9	fradiae	fradiae	NN
cord-021419-nypnib0h	590	10	ATCC	ATCC	NNP
cord-021419-nypnib0h	591	1	19609	19609	CD
cord-021419-nypnib0h	592	1	sensitive	sensitive	JJ
cord-021419-nypnib0h	592	2	to	to	IN
cord-021419-nypnib0h	592	3	very	very	RB
cord-021419-nypnib0h	592	4	low	low	JJ
cord-021419-nypnib0h	592	5	concentrations	concentration	NNS
cord-021419-nypnib0h	592	6	of	of	IN
cord-021419-nypnib0h	592	7	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	592	8	(	(	-LRB-
cord-021419-nypnib0h	592	9	<	<	NNP
cord-021419-nypnib0h	592	10	0.001	0.001	CD
cord-021419-nypnib0h	592	11	nmol	nmol	NNP
cord-021419-nypnib0h	592	12	mL	mL	NNP
cord-021419-nypnib0h	592	13	71	71	CD
cord-021419-nypnib0h	592	14	or	or	CC
cord-021419-nypnib0h	592	15	0.0005	0.0005	CD
cord-021419-nypnib0h	592	16	nmol	nmol	NN
cord-021419-nypnib0h	592	17	per	per	IN
cord-021419-nypnib0h	592	18	disc	disc	NN
cord-021419-nypnib0h	592	19	surface	surface	NN
cord-021419-nypnib0h	592	20	)	)	-RRB-
cord-021419-nypnib0h	592	21	and	and	CC
cord-021419-nypnib0h	592	22	hypersensitive	hypersensitive	JJ
cord-021419-nypnib0h	592	23	to	to	IN
cord-021419-nypnib0h	592	24	most	most	JJS
cord-021419-nypnib0h	592	25	of	of	IN
cord-021419-nypnib0h	592	26	the	the	DT
cord-021419-nypnib0h	592	27	known	know	VBN
cord-021419-nypnib0h	592	28	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	593	1	was	be	VBD
cord-021419-nypnib0h	593	2	used	use	VBN
cord-021419-nypnib0h	593	3	to	to	TO
cord-021419-nypnib0h	593	4	study	study	VB
cord-021419-nypnib0h	593	5	the	the	DT
cord-021419-nypnib0h	593	6	mechanism	mechanism	NN
cord-021419-nypnib0h	593	7	of	of	IN
cord-021419-nypnib0h	593	8	resistance	resistance	NN
cord-021419-nypnib0h	593	9	of	of	IN
cord-021419-nypnib0h	593	10	microorganisms	microorganism	NNS
cord-021419-nypnib0h	593	11	.	.	.
cord-021419-nypnib0h	594	1	66	66	CD
cord-021419-nypnib0h	594	2	Mutant	mutant	JJ
cord-021419-nypnib0h	594	3	strains	strain	NNS
cord-021419-nypnib0h	594	4	of	of	IN
cord-021419-nypnib0h	594	5	this	this	DT
cord-021419-nypnib0h	594	6	microorganism	microorganism	NN
cord-021419-nypnib0h	594	7	sensitive	sensitive	JJ
cord-021419-nypnib0h	594	8	to	to	IN
cord-021419-nypnib0h	594	9	analogues	analogue	NNS
cord-021419-nypnib0h	594	10	of	of	IN
cord-021419-nypnib0h	594	11	compounds	compound	NNS
cord-021419-nypnib0h	594	12	92	92	CD
cord-021419-nypnib0h	595	1	(	(	-LRB-
cord-021419-nypnib0h	595	2	Ref	ref	NN
cord-021419-nypnib0h	595	3	.	.	.
cord-021419-nypnib0h	595	4	67	67	CD
cord-021419-nypnib0h	595	5	)	)	-RRB-
cord-021419-nypnib0h	596	1	and	and	CC
cord-021419-nypnib0h	596	2	108a	108a	NNS
cord-021419-nypnib0h	596	3	,	,	,
cord-021419-nypnib0h	596	4	as	as	IN
cord-021419-nypnib0h	596	5	opposed	oppose	VBN
cord-021419-nypnib0h	596	6	to	to	IN
cord-021419-nypnib0h	596	7	the	the	DT
cord-021419-nypnib0h	596	8	starting	start	VBG
cord-021419-nypnib0h	596	9	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	596	10	90a	90a	NNS
cord-021419-nypnib0h	596	11	and	and	CC
cord-021419-nypnib0h	596	12	other	other	JJ
cord-021419-nypnib0h	596	13	derivatives	derivative	NNS
cord-021419-nypnib0h	596	14	,	,	,
cord-021419-nypnib0h	596	15	were	be	VBD
cord-021419-nypnib0h	596	16	produced	produce	VBN
cord-021419-nypnib0h	596	17	under	under	IN
cord-021419-nypnib0h	596	18	experimental	experimental	JJ
cord-021419-nypnib0h	596	19	conditions	condition	NNS
cord-021419-nypnib0h	596	20	.	.	.
cord-021419-nypnib0h	597	1	The	the	DT
cord-021419-nypnib0h	597	2	results	result	NNS
cord-021419-nypnib0h	597	3	of	of	IN
cord-021419-nypnib0h	597	4	assays	assay	NNS
cord-021419-nypnib0h	597	5	demonstrated	demonstrate	VBD
cord-021419-nypnib0h	597	6	that	that	IN
cord-021419-nypnib0h	597	7	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	597	8	90a	90a	NNS
cord-021419-nypnib0h	597	9	has	have	VBZ
cord-021419-nypnib0h	597	10	several	several	JJ
cord-021419-nypnib0h	597	11	biotargets	biotarget	NNS
cord-021419-nypnib0h	597	12	.	.	.
cord-021419-nypnib0h	598	1	These	these	DT
cord-021419-nypnib0h	598	2	data	datum	NNS
cord-021419-nypnib0h	598	3	confirm	confirm	VBP
cord-021419-nypnib0h	598	4	the	the	DT
cord-021419-nypnib0h	598	5	conclusion	conclusion	NN
cord-021419-nypnib0h	598	6	that	that	IN
cord-021419-nypnib0h	598	7	both	both	CC
cord-021419-nypnib0h	598	8	the	the	DT
cord-021419-nypnib0h	598	9	diene	diene	NN
cord-021419-nypnib0h	598	10	system	system	NN
cord-021419-nypnib0h	598	11	of	of	IN
cord-021419-nypnib0h	598	12	the	the	DT
cord-021419-nypnib0h	598	13	macrocycle	macrocycle	NNP
cord-021419-nypnib0h	598	14	and	and	CC
cord-021419-nypnib0h	598	15	its	-PRON-	PRP$
cord-021419-nypnib0h	598	16	hydroxypropyl	hydroxypropyl	NNP
cord-021419-nypnib0h	598	17	side	side	NN
cord-021419-nypnib0h	598	18	chain	chain	NN
cord-021419-nypnib0h	598	19	play	play	VB
cord-021419-nypnib0h	598	20	an	an	DT
cord-021419-nypnib0h	598	21	important	important	JJ
cord-021419-nypnib0h	598	22	role	role	NN
cord-021419-nypnib0h	598	23	in	in	IN
cord-021419-nypnib0h	598	24	biological	biological	JJ
cord-021419-nypnib0h	598	25	activity	activity	NN
cord-021419-nypnib0h	598	26	.	.	.
cord-021419-nypnib0h	599	1	65	65	CD
cord-021419-nypnib0h	600	1	Therefore	therefore	RB
cord-021419-nypnib0h	600	2	,	,	,
cord-021419-nypnib0h	600	3	the	the	DT
cord-021419-nypnib0h	600	4	chemical	chemical	JJ
cord-021419-nypnib0h	600	5	modification	modification	NN
cord-021419-nypnib0h	600	6	of	of	IN
cord-021419-nypnib0h	600	7	the	the	DT
cord-021419-nypnib0h	600	8	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	600	9	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	600	10	(	(	-LRB-
cord-021419-nypnib0h	600	11	90a	90a	NNS
cord-021419-nypnib0h	600	12	)	)	-RRB-
cord-021419-nypnib0h	600	13	,	,	,
cord-021419-nypnib0h	600	14	a	a	DT
cord-021419-nypnib0h	600	15	highly	highly	RB
cord-021419-nypnib0h	600	16	active	active	JJ
cord-021419-nypnib0h	600	17	F	f	NN
cord-021419-nypnib0h	600	18	0	0	CD
cord-021419-nypnib0h	600	19	F	F	NNP
cord-021419-nypnib0h	600	20	1	1	CD
cord-021419-nypnib0h	600	21	-ATP	-ATP	:
cord-021419-nypnib0h	600	22	synthase	synthase	NN
cord-021419-nypnib0h	600	23	inhibitor	inhibitor	NN
cord-021419-nypnib0h	600	24	,	,	,
cord-021419-nypnib0h	600	25	was	be	VBD
cord-021419-nypnib0h	600	26	performed	perform	VBN
cord-021419-nypnib0h	600	27	for	for	IN
cord-021419-nypnib0h	600	28	the	the	DT
cord-021419-nypnib0h	600	29	first	first	JJ
cord-021419-nypnib0h	600	30	time	time	NN
cord-021419-nypnib0h	600	31	.	.	.
cord-021419-nypnib0h	601	1	More	More	JJR
cord-021419-nypnib0h	601	2	than	than	IN
cord-021419-nypnib0h	601	3	20	20	CD
cord-021419-nypnib0h	601	4	new	new	JJ
cord-021419-nypnib0h	601	5	semi	semi	JJ
cord-021419-nypnib0h	601	6	-	-	JJ
cord-021419-nypnib0h	601	7	synthetic	synthetic	JJ
cord-021419-nypnib0h	601	8	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	601	9	derivatives	derivative	NNS
cord-021419-nypnib0h	601	10	were	be	VBD
cord-021419-nypnib0h	601	11	prepared	prepare	VBN
cord-021419-nypnib0h	601	12	and	and	CC
cord-021419-nypnib0h	601	13	the	the	DT
cord-021419-nypnib0h	601	14	mechanism	mechanism	NN
cord-021419-nypnib0h	601	15	of	of	IN
cord-021419-nypnib0h	601	16	their	-PRON-	PRP$
cord-021419-nypnib0h	601	17	action	action	NN
cord-021419-nypnib0h	601	18	was	be	VBD
cord-021419-nypnib0h	601	19	studied	study	VBN
cord-021419-nypnib0h	601	20	.	.	.
cord-021419-nypnib0h	602	1	Analogues	analogue	NNS
cord-021419-nypnib0h	602	2	with	with	IN
cord-021419-nypnib0h	602	3	selective	selective	JJ
cord-021419-nypnib0h	602	4	antitumour	antitumour	NN
cord-021419-nypnib0h	602	5	or	or	CC
cord-021419-nypnib0h	602	6	anti	anti	JJ
cord-021419-nypnib0h	602	7	-	-	JJ
cord-021419-nypnib0h	602	8	infective	infective	JJ
cord-021419-nypnib0h	602	9	activity	activity	NN
cord-021419-nypnib0h	602	10	were	be	VBD
cord-021419-nypnib0h	602	11	synthesized	synthesize	VBN
cord-021419-nypnib0h	602	12	.	.	.
cord-021419-nypnib0h	603	1	The	the	DT
cord-021419-nypnib0h	603	2	chemical	chemical	JJ
cord-021419-nypnib0h	603	3	modification	modification	NN
cord-021419-nypnib0h	603	4	of	of	IN
cord-021419-nypnib0h	603	5	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	603	6	90a	90a	NNS
cord-021419-nypnib0h	603	7	,	,	,
cord-021419-nypnib0h	603	8	which	which	WDT
cord-021419-nypnib0h	603	9	enables	enable	VBZ
cord-021419-nypnib0h	603	10	the	the	DT
cord-021419-nypnib0h	603	11	efficient	efficient	JJ
cord-021419-nypnib0h	603	12	modulation	modulation	NN
cord-021419-nypnib0h	603	13	of	of	IN
cord-021419-nypnib0h	603	14	its	-PRON-	PRP$
cord-021419-nypnib0h	603	15	biological	biological	JJ
cord-021419-nypnib0h	603	16	activity	activity	NN
cord-021419-nypnib0h	603	17	due	due	IN
cord-021419-nypnib0h	603	18	to	to	IN
cord-021419-nypnib0h	603	19	a	a	DT
cord-021419-nypnib0h	603	20	decrease	decrease	NN
cord-021419-nypnib0h	603	21	in	in	IN
cord-021419-nypnib0h	603	22	the	the	DT
cord-021419-nypnib0h	603	23	binding	binding	NN
cord-021419-nypnib0h	603	24	to	to	IN
cord-021419-nypnib0h	603	25	F	F	NNP
cord-021419-nypnib0h	603	26	0	0	CD
cord-021419-nypnib0h	603	27	F	F	NNP
cord-021419-nypnib0h	603	28	1	1	CD
cord-021419-nypnib0h	603	29	-ATP	-ATP	:
cord-021419-nypnib0h	603	30	synthase	synthase	NN
cord-021419-nypnib0h	603	31	,	,	,
cord-021419-nypnib0h	603	32	was	be	VBD
cord-021419-nypnib0h	603	33	found	find	VBN
cord-021419-nypnib0h	603	34	.	.	.
cord-021419-nypnib0h	604	1	This	this	DT
cord-021419-nypnib0h	604	2	provides	provide	VBZ
cord-021419-nypnib0h	604	3	the	the	DT
cord-021419-nypnib0h	604	4	possibility	possibility	NN
cord-021419-nypnib0h	604	5	to	to	TO
cord-021419-nypnib0h	604	6	optimize	optimize	VB
cord-021419-nypnib0h	604	7	pharmacological	pharmacological	JJ
cord-021419-nypnib0h	604	8	properties	property	NNS
cord-021419-nypnib0h	604	9	.	.	.
cord-021419-nypnib0h	605	1	Olivomycin	Olivomycin	NNP
cord-021419-nypnib0h	605	2	A	A	NNP
cord-021419-nypnib0h	605	3	(	(	-LRB-
cord-021419-nypnib0h	605	4	110	110	CD
cord-021419-nypnib0h	605	5	)	)	-RRB-
cord-021419-nypnib0h	605	6	(	(	-LRB-
cord-021419-nypnib0h	605	7	hereinafter	hereinafter	NNP
cord-021419-nypnib0h	605	8	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	605	9	)	)	-RRB-
cord-021419-nypnib0h	605	10	is	be	VBZ
cord-021419-nypnib0h	605	11	a	a	DT
cord-021419-nypnib0h	605	12	highly	highly	RB
cord-021419-nypnib0h	605	13	effective	effective	JJ
cord-021419-nypnib0h	605	14	antibiotic	antibiotic	NN
cord-021419-nypnib0h	605	15	with	with	IN
cord-021419-nypnib0h	605	16	a	a	DT
cord-021419-nypnib0h	605	17	unique	unique	JJ
cord-021419-nypnib0h	605	18	mechanism	mechanism	NN
cord-021419-nypnib0h	605	19	of	of	IN
cord-021419-nypnib0h	605	20	antitumour	antitumour	JJ
cord-021419-nypnib0h	605	21	activity	activity	NN
cord-021419-nypnib0h	605	22	discovered	discover	VBN
cord-021419-nypnib0h	605	23	in	in	IN
cord-021419-nypnib0h	605	24	the	the	DT
cord-021419-nypnib0h	605	25	Gause	Gause	NNP
cord-021419-nypnib0h	605	26	Institute	Institute	NNP
cord-021419-nypnib0h	605	27	of	of	IN
cord-021419-nypnib0h	605	28	New	New	NNP
cord-021419-nypnib0h	605	29	Antibiotics	Antibiotics	NNP
cord-021419-nypnib0h	605	30	6	6	CD
cord-021419-nypnib0h	605	31	,	,	,
cord-021419-nypnib0h	605	32	68	68	CD
cord-021419-nypnib0h	605	33	,	,	,
cord-021419-nypnib0h	605	34	69	69	CD
cord-021419-nypnib0h	606	1	(	(	-LRB-
cord-021419-nypnib0h	606	2	Fig	Fig	NNP
cord-021419-nypnib0h	606	3	.	.	NNP
cord-021419-nypnib0h	606	4	7	7	CD
cord-021419-nypnib0h	606	5	)	)	-RRB-
cord-021419-nypnib0h	606	6	.	.	.
cord-021419-nypnib0h	607	1	Its	-PRON-	PRP$
cord-021419-nypnib0h	607	2	structure	structure	NN
cord-021419-nypnib0h	607	3	consists	consist	VBZ
cord-021419-nypnib0h	607	4	of	of	IN
cord-021419-nypnib0h	607	5	the	the	DT
cord-021419-nypnib0h	607	6	aglycone	aglycone	NNP
cord-021419-nypnib0h	607	7	olivin	olivin	NNP
cord-021419-nypnib0h	607	8	and	and	CC
cord-021419-nypnib0h	607	9	two	two	CD
cord-021419-nypnib0h	607	10	carbohydrate	carbohydrate	NN
cord-021419-nypnib0h	607	11	chains	chain	NNS
cord-021419-nypnib0h	607	12	attached	attach	VBN
cord-021419-nypnib0h	607	13	to	to	IN
cord-021419-nypnib0h	607	14	the	the	DT
cord-021419-nypnib0h	607	15	aglycone	aglycone	NN
cord-021419-nypnib0h	607	16	at	at	IN
cord-021419-nypnib0h	607	17	the	the	DT
cord-021419-nypnib0h	607	18	2	2	CD
cord-021419-nypnib0h	607	19	and	and	CC
cord-021419-nypnib0h	607	20	6	6	CD
cord-021419-nypnib0h	607	21	positions	position	NNS
cord-021419-nypnib0h	607	22	.	.	.
cord-021419-nypnib0h	608	1	The	the	DT
cord-021419-nypnib0h	608	2	antibiotic	antibiotic	NN
cord-021419-nypnib0h	608	3	is	be	VBZ
cord-021419-nypnib0h	608	4	a	a	DT
cord-021419-nypnib0h	608	5	DNA	dna	NN
cord-021419-nypnib0h	608	6	duplex	duplex	JJ
cord-021419-nypnib0h	608	7	minor	minor	JJ
cord-021419-nypnib0h	608	8	groove	groove	NN
cord-021419-nypnib0h	608	9	ligand	ligand	NN
cord-021419-nypnib0h	608	10	,	,	,
cord-021419-nypnib0h	608	11	which	which	WDT
cord-021419-nypnib0h	608	12	binds	bind	VBZ
cord-021419-nypnib0h	608	13	to	to	IN
cord-021419-nypnib0h	608	14	the	the	DT
cord-021419-nypnib0h	608	15	guanine	guanine	NN
cord-021419-nypnib0h	608	16	-	-	HYPH
cord-021419-nypnib0h	608	17	cytosine	cytosine	JJ
cord-021419-nypnib0h	608	18	(	(	-LRB-
cord-021419-nypnib0h	608	19	GC)-rich	gc)-rich	CD
cord-021419-nypnib0h	608	20	region	region	NN
cord-021419-nypnib0h	608	21	.	.	.
cord-021419-nypnib0h	609	1	Compared	compare	VBN
cord-021419-nypnib0h	609	2	to	to	IN
cord-021419-nypnib0h	609	3	other	other	JJ
cord-021419-nypnib0h	609	4	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	609	5	of	of	IN
cord-021419-nypnib0h	609	6	the	the	DT
cord-021419-nypnib0h	609	7	aureolic	aureolic	NNP
cord-021419-nypnib0h	609	8	acid	acid	NNP
cord-021419-nypnib0h	609	9	group	group	NNP
cord-021419-nypnib0h	609	10	(	(	-LRB-
cord-021419-nypnib0h	609	11	mithramycin	mithramycin	NNP
cord-021419-nypnib0h	609	12	and	and	CC
cord-021419-nypnib0h	609	13	chromomycin	chromomycin	NNS
cord-021419-nypnib0h	609	14	A	A	NNP
cord-021419-nypnib0h	609	15	)	)	-RRB-
cord-021419-nypnib0h	609	16	,	,	,
cord-021419-nypnib0h	609	17	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	609	18	110	110	CD
cord-021419-nypnib0h	609	19	has	have	VBZ
cord-021419-nypnib0h	609	20	better	well	JJR
cord-021419-nypnib0h	609	21	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	609	22	efficacy	efficacy	NN
cord-021419-nypnib0h	609	23	.	.	.
cord-021419-nypnib0h	610	1	In	in	IN
cord-021419-nypnib0h	610	2	recent	recent	JJ
cord-021419-nypnib0h	610	3	years	year	NNS
cord-021419-nypnib0h	610	4	,	,	,
cord-021419-nypnib0h	610	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	610	6	of	of	IN
cord-021419-nypnib0h	610	7	this	this	DT
cord-021419-nypnib0h	610	8	group	group	NN
cord-021419-nypnib0h	610	9	have	have	VBP
cord-021419-nypnib0h	610	10	attracted	attract	VBN
cord-021419-nypnib0h	610	11	increasing	increase	VBG
cord-021419-nypnib0h	610	12	interest	interest	NN
cord-021419-nypnib0h	610	13	.	.	.
cord-021419-nypnib0h	611	1	70	70	CD
cord-021419-nypnib0h	611	2	,	,	,
cord-021419-nypnib0h	611	3	71	71	CD
cord-021419-nypnib0h	611	4	Antibiotics	antibiotic	NNS
cord-021419-nypnib0h	611	5	of	of	IN
cord-021419-nypnib0h	611	6	this	this	DT
cord-021419-nypnib0h	611	7	group	group	NN
cord-021419-nypnib0h	611	8	were	be	VBD
cord-021419-nypnib0h	611	9	shown	show	VBN
cord-021419-nypnib0h	611	10	to	to	TO
cord-021419-nypnib0h	611	11	be	be	VB
cord-021419-nypnib0h	611	12	able	able	JJ
cord-021419-nypnib0h	611	13	to	to	TO
cord-021419-nypnib0h	611	14	prevent	prevent	VB
cord-021419-nypnib0h	611	15	the	the	DT
cord-021419-nypnib0h	611	16	development	development	NN
cord-021419-nypnib0h	611	17	of	of	IN
cord-021419-nypnib0h	611	18	resistance	resistance	NN
cord-021419-nypnib0h	611	19	of	of	IN
cord-021419-nypnib0h	611	20	tumour	tumour	NN
cord-021419-nypnib0h	611	21	cells	cell	NNS
cord-021419-nypnib0h	611	22	to	to	IN
cord-021419-nypnib0h	611	23	other	other	JJ
cord-021419-nypnib0h	611	24	antitumour	antitumour	JJ
cord-021419-nypnib0h	611	25	agents	agent	NNS
cord-021419-nypnib0h	611	26	,	,	,
cord-021419-nypnib0h	611	27	in	in	IN
cord-021419-nypnib0h	611	28	particular	particular	JJ
cord-021419-nypnib0h	611	29	via	via	IN
cord-021419-nypnib0h	611	30	a	a	DT
cord-021419-nypnib0h	611	31	mechanism	mechanism	NN
cord-021419-nypnib0h	611	32	involving	involve	VBG
cord-021419-nypnib0h	611	33	the	the	DT
cord-021419-nypnib0h	611	34	inhibition	inhibition	NN
cord-021419-nypnib0h	611	35	of	of	IN
cord-021419-nypnib0h	611	36	transcription	transcription	NN
cord-021419-nypnib0h	611	37	of	of	IN
cord-021419-nypnib0h	611	38	the	the	DT
cord-021419-nypnib0h	611	39	MDR1	MDR1	NNP
cord-021419-nypnib0h	611	40	gene	gene	NN
cord-021419-nypnib0h	611	41	,	,	,
cord-021419-nypnib0h	611	42	overexpression	overexpression	NN
cord-021419-nypnib0h	611	43	of	of	IN
cord-021419-nypnib0h	611	44	which	which	WDT
cord-021419-nypnib0h	611	45	is	be	VBZ
cord-021419-nypnib0h	611	46	responsible	responsible	JJ
cord-021419-nypnib0h	611	47	for	for	IN
cord-021419-nypnib0h	611	48	multidrug	multidrug	NN
cord-021419-nypnib0h	611	49	resistance	resistance	NN
cord-021419-nypnib0h	611	50	of	of	IN
cord-021419-nypnib0h	611	51	tumour	tumour	NN
cord-021419-nypnib0h	611	52	cells	cell	NNS
cord-021419-nypnib0h	611	53	.	.	.
cord-021419-nypnib0h	612	1	Mithramycin	Mithramycin	NNP
cord-021419-nypnib0h	612	2	is	be	VBZ
cord-021419-nypnib0h	612	3	used	use	VBN
cord-021419-nypnib0h	612	4	to	to	TO
cord-021419-nypnib0h	612	5	treat	treat	VB
cord-021419-nypnib0h	612	6	Paget	Paget	NNP
cord-021419-nypnib0h	612	7	's	's	POS
cord-021419-nypnib0h	612	8	disease	disease	NN
cord-021419-nypnib0h	612	9	and	and	CC
cord-021419-nypnib0h	612	10	testicular	testicular	JJ
cord-021419-nypnib0h	612	11	carcinoma	carcinoma	NN
cord-021419-nypnib0h	612	12	.	.	.
cord-021419-nypnib0h	613	1	Chromomycin	Chromomycin	NNP
cord-021419-nypnib0h	613	2	is	be	VBZ
cord-021419-nypnib0h	613	3	a	a	DT
cord-021419-nypnib0h	613	4	drug	drug	NN
cord-021419-nypnib0h	613	5	of	of	IN
cord-021419-nypnib0h	613	6	limited	limited	JJ
cord-021419-nypnib0h	613	7	use	use	NN
cord-021419-nypnib0h	613	8	in	in	IN
cord-021419-nypnib0h	613	9	Japan	Japan	NNP
cord-021419-nypnib0h	613	10	for	for	IN
cord-021419-nypnib0h	613	11	the	the	DT
cord-021419-nypnib0h	613	12	treatment	treatment	NN
cord-021419-nypnib0h	613	13	of	of	IN
cord-021419-nypnib0h	613	14	gastrointestinal	gastrointestinal	JJ
cord-021419-nypnib0h	613	15	cancer	cancer	NN
cord-021419-nypnib0h	613	16	.	.	.
cord-021419-nypnib0h	614	1	Olivomycin	Olivomycin	NNP
cord-021419-nypnib0h	614	2	(	(	-LRB-
cord-021419-nypnib0h	614	3	110	110	CD
cord-021419-nypnib0h	614	4	)	)	-RRB-
cord-021419-nypnib0h	614	5	was	be	VBD
cord-021419-nypnib0h	614	6	applied	apply	VBN
cord-021419-nypnib0h	614	7	in	in	IN
cord-021419-nypnib0h	614	8	the	the	DT
cord-021419-nypnib0h	614	9	USSR	USSR	NNP
cord-021419-nypnib0h	614	10	for	for	IN
cord-021419-nypnib0h	614	11	the	the	DT
cord-021419-nypnib0h	614	12	treatment	treatment	NN
cord-021419-nypnib0h	614	13	of	of	IN
cord-021419-nypnib0h	614	14	ovarian	ovarian	JJ
cord-021419-nypnib0h	614	15	cancer	cancer	NN
cord-021419-nypnib0h	614	16	,	,	,
cord-021419-nypnib0h	614	17	reticulosarcoma	reticulosarcoma	NNP
cord-021419-nypnib0h	614	18	and	and	CC
cord-021419-nypnib0h	614	19	some	some	DT
cord-021419-nypnib0h	614	20	other	other	JJ
cord-021419-nypnib0h	614	21	tumours	tumour	NNS
cord-021419-nypnib0h	614	22	.	.	.
cord-021419-nypnib0h	615	1	However	however	RB
cord-021419-nypnib0h	615	2	,	,	,
cord-021419-nypnib0h	615	3	serious	serious	JJ
cord-021419-nypnib0h	615	4	adverse	adverse	JJ
cord-021419-nypnib0h	615	5	effects	effect	NNS
cord-021419-nypnib0h	615	6	limit	limit	VBP
cord-021419-nypnib0h	615	7	the	the	DT
cord-021419-nypnib0h	615	8	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	615	9	potential	potential	NN
cord-021419-nypnib0h	615	10	of	of	IN
cord-021419-nypnib0h	615	11	these	these	DT
cord-021419-nypnib0h	615	12	drugs	drug	NNS
cord-021419-nypnib0h	615	13	.	.	.
cord-021419-nypnib0h	616	1	Various	various	JJ
cord-021419-nypnib0h	616	2	aspects	aspect	NNS
cord-021419-nypnib0h	616	3	of	of	IN
cord-021419-nypnib0h	616	4	antitumour	antitumour	JJ
cord-021419-nypnib0h	616	5	activity	activity	NN
cord-021419-nypnib0h	616	6	of	of	IN
cord-021419-nypnib0h	616	7	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	616	8	of	of	IN
cord-021419-nypnib0h	616	9	the	the	DT
cord-021419-nypnib0h	616	10	aureolic	aureolic	NNP
cord-021419-nypnib0h	616	11	acid	acid	NNP
cord-021419-nypnib0h	616	12	group	group	NNP
cord-021419-nypnib0h	616	13	were	be	VBD
cord-021419-nypnib0h	616	14	addressed	address	VBN
cord-021419-nypnib0h	616	15	in	in	IN
cord-021419-nypnib0h	616	16	detail	detail	NN
cord-021419-nypnib0h	616	17	;	;	:
cord-021419-nypnib0h	616	18	however	however	RB
cord-021419-nypnib0h	616	19	,	,	,
cord-021419-nypnib0h	616	20	chemical	chemical	NN
cord-021419-nypnib0h	616	21	modifications	modification	NNS
cord-021419-nypnib0h	616	22	of	of	IN
cord-021419-nypnib0h	616	23	this	this	DT
cord-021419-nypnib0h	616	24	class	class	NN
cord-021419-nypnib0h	616	25	of	of	IN
cord-021419-nypnib0h	616	26	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	616	27	are	be	VBP
cord-021419-nypnib0h	616	28	poorly	poorly	RB
cord-021419-nypnib0h	616	29	known	know	VBN
cord-021419-nypnib0h	616	30	.	.	.
cord-021419-nypnib0h	617	1	Selective	selective	JJ
cord-021419-nypnib0h	617	2	modifications	modification	NNS
cord-021419-nypnib0h	617	3	of	of	IN
cord-021419-nypnib0h	617	4	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	617	5	(	(	-LRB-
cord-021419-nypnib0h	617	6	110	110	CD
cord-021419-nypnib0h	617	7	)	)	-RRB-
cord-021419-nypnib0h	617	8	at	at	IN
cord-021419-nypnib0h	617	9	the	the	DT
cord-021419-nypnib0h	617	10	C(5	C(5	NNP
cord-021419-nypnib0h	617	11	)	)	-RRB-
cord-021419-nypnib0h	617	12	atom	atom	NN
cord-021419-nypnib0h	617	13	(	(	-LRB-
cord-021419-nypnib0h	617	14	a	a	NN
cord-021419-nypnib0h	617	15	)	)	-RRB-
cord-021419-nypnib0h	617	16	,	,	,
cord-021419-nypnib0h	617	17	the	the	DT
cord-021419-nypnib0h	617	18	C(8)7OH	C(8)7OH	NNP
cord-021419-nypnib0h	617	19	(	(	-LRB-
cord-021419-nypnib0h	617	20	b	b	NN
cord-021419-nypnib0h	617	21	)	)	-RRB-
cord-021419-nypnib0h	617	22	and	and	CC
cord-021419-nypnib0h	617	23	C(2	C(2	NNP
cord-021419-nypnib0h	617	24	H	h	NN
cord-021419-nypnib0h	617	25	)	)	-RRB-
cord-021419-nypnib0h	617	26	=	=	NFP
cord-021419-nypnib0h	618	1	O	o	UH
cord-021419-nypnib0h	618	2	groups	group	NNS
cord-021419-nypnib0h	618	3	(	(	-LRB-
cord-021419-nypnib0h	618	4	c	c	NNP
cord-021419-nypnib0h	618	5	)	)	-RRB-
cord-021419-nypnib0h	618	6	,	,	,
cord-021419-nypnib0h	618	7	the	the	DT
cord-021419-nypnib0h	618	8	C(2	C(2	NNP
cord-021419-nypnib0h	618	9	H	H	NNP
cord-021419-nypnib0h	618	10	)	)	-RRB-
cord-021419-nypnib0h	618	11	7C(3	7c(3	CD
cord-021419-nypnib0h	618	12	H	h	NN
cord-021419-nypnib0h	618	13	)	)	-RRB-
cord-021419-nypnib0h	618	14	bond	bond	NN
cord-021419-nypnib0h	618	15	(	(	-LRB-
cord-021419-nypnib0h	618	16	d	d	NNP
cord-021419-nypnib0h	618	17	)	)	-RRB-
cord-021419-nypnib0h	618	18	and	and	CC
cord-021419-nypnib0h	618	19	the	the	DT
cord-021419-nypnib0h	618	20	residues	residue	NNS
cord-021419-nypnib0h	618	21	A4	A4	NNP
cord-021419-nypnib0h	618	22	and	and	CC
cord-021419-nypnib0h	618	23	E4	E4	NNP
cord-021419-nypnib0h	618	24	(	(	-LRB-
cord-021419-nypnib0h	618	25	e	e	NN
cord-021419-nypnib0h	618	26	)	)	-RRB-
cord-021419-nypnib0h	619	1	(	(	-LRB-
cord-021419-nypnib0h	619	2	see	see	VB
cord-021419-nypnib0h	619	3	Fig	Fig	NNP
cord-021419-nypnib0h	619	4	.	.	NNP
cord-021419-nypnib0h	619	5	7	7	CD
cord-021419-nypnib0h	619	6	)	)	-RRB-
cord-021419-nypnib0h	619	7	were	be	VBD
cord-021419-nypnib0h	619	8	developed	develop	VBN
cord-021419-nypnib0h	619	9	in	in	IN
cord-021419-nypnib0h	619	10	the	the	DT
cord-021419-nypnib0h	619	11	Gause	Gause	NNP
cord-021419-nypnib0h	619	12	Institute	Institute	NNP
cord-021419-nypnib0h	619	13	of	of	IN
cord-021419-nypnib0h	619	14	New	New	NNP
cord-021419-nypnib0h	619	15	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	619	16	.	.	.
cord-021419-nypnib0h	620	1	The	the	DT
cord-021419-nypnib0h	620	2	selective	selective	JJ
cord-021419-nypnib0h	620	3	acylation	acylation	NN
cord-021419-nypnib0h	620	4	of	of	IN
cord-021419-nypnib0h	620	5	compound	compound	NN
cord-021419-nypnib0h	620	6	110	110	CD
cord-021419-nypnib0h	620	7	at	at	IN
cord-021419-nypnib0h	620	8	the	the	DT
cord-021419-nypnib0h	620	9	phenolic	phenolic	JJ
cord-021419-nypnib0h	620	10	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	620	11	group	group	NN
cord-021419-nypnib0h	620	12	at	at	IN
cord-021419-nypnib0h	620	13	the	the	DT
cord-021419-nypnib0h	620	14	C(8	C(8	NNP
cord-021419-nypnib0h	620	15	)	)	-RRB-
cord-021419-nypnib0h	620	16	atom	atom	NN
cord-021419-nypnib0h	620	17	with	with	IN
cord-021419-nypnib0h	620	18	a	a	DT
cord-021419-nypnib0h	620	19	Ac	Ac	NNP
cord-021419-nypnib0h	620	20	2	2	CD
cord-021419-nypnib0h	620	21	O7Py	o7py	CD
cord-021419-nypnib0h	620	22	mixture	mixture	NN
cord-021419-nypnib0h	620	23	affords	afford	VBZ
cord-021419-nypnib0h	620	24	8-O	8-o	CD
cord-021419-nypnib0h	620	25	-	-	HYPH
cord-021419-nypnib0h	620	26	acetylolivomycin	acetylolivomycin	NNP
cord-021419-nypnib0h	620	27	(	(	-LRB-
cord-021419-nypnib0h	620	28	111	111	CD
cord-021419-nypnib0h	620	29	)	)	-RRB-
cord-021419-nypnib0h	621	1	(	(	-LRB-
cord-021419-nypnib0h	621	2	Scheme	scheme	NN
cord-021419-nypnib0h	621	3	31	31	CD
cord-021419-nypnib0h	621	4	)	)	-RRB-
cord-021419-nypnib0h	621	5	.	.	.
cord-021419-nypnib0h	622	1	72	72	CD
cord-021419-nypnib0h	623	1	An	an	DT
cord-021419-nypnib0h	623	2	investigation	investigation	NN
cord-021419-nypnib0h	623	3	of	of	IN
cord-021419-nypnib0h	623	4	the	the	DT
cord-021419-nypnib0h	623	5	reaction	reaction	NN
cord-021419-nypnib0h	623	6	of	of	IN
cord-021419-nypnib0h	623	7	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	623	8	(	(	-LRB-
cord-021419-nypnib0h	623	9	110	110	CD
cord-021419-nypnib0h	623	10	)	)	-RRB-
cord-021419-nypnib0h	623	11	with	with	IN
cord-021419-nypnib0h	623	12	aryldiazonium	aryldiazonium	NN
cord-021419-nypnib0h	623	13	salts	salt	NNS
cord-021419-nypnib0h	623	14	showed	show	VBD
cord-021419-nypnib0h	623	15	that	that	IN
cord-021419-nypnib0h	623	16	the	the	DT
cord-021419-nypnib0h	623	17	azo	azo	NN
cord-021419-nypnib0h	623	18	coupling	coupling	NN
cord-021419-nypnib0h	623	19	gives	give	VBZ
cord-021419-nypnib0h	623	20	aryldiazenes	aryldiazenes	NNP
cord-021419-nypnib0h	623	21	monosubstituted	monosubstitute	VBN
cord-021419-nypnib0h	623	22	at	at	IN
cord-021419-nypnib0h	623	23	the	the	DT
cord-021419-nypnib0h	623	24	5	5	CD
cord-021419-nypnib0h	623	25	position	position	NN
cord-021419-nypnib0h	623	26	of	of	IN
cord-021419-nypnib0h	623	27	the	the	DT
cord-021419-nypnib0h	623	28	aglycone	aglycone	NN
cord-021419-nypnib0h	623	29	accompanied	accompany	VBN
cord-021419-nypnib0h	623	30	by	by	IN
cord-021419-nypnib0h	623	31	the	the	DT
cord-021419-nypnib0h	623	32	elimination	elimination	NN
cord-021419-nypnib0h	623	33	of	of	IN
cord-021419-nypnib0h	623	34	the	the	DT
cord-021419-nypnib0h	623	35	disaccharide	disaccharide	JJ
cord-021419-nypnib0h	623	36	branch	branch	NN
cord-021419-nypnib0h	623	37	at	at	IN
cord-021419-nypnib0h	623	38	the	the	DT
cord-021419-nypnib0h	623	39	C(6	C(6	NNP
cord-021419-nypnib0h	623	40	)	)	-RRB-
cord-021419-nypnib0h	623	41	atom	atom	NN
cord-021419-nypnib0h	623	42	:	:	:
cord-021419-nypnib0h	623	43	5-(phenyldiazenyl)olivomycin	5-(phenyldiazenyl)olivomycin	NNP
cord-021419-nypnib0h	623	44	(	(	-LRB-
cord-021419-nypnib0h	623	45	112	112	CD
cord-021419-nypnib0h	623	46	)	)	-RRB-
cord-021419-nypnib0h	623	47	,	,	,
cord-021419-nypnib0h	623	48	5-(4-sulfamidophenyldiazenyl)olivomycin	5-(4-sulfamidophenyldiazenyl)olivomycin	NNS
cord-021419-nypnib0h	623	49	(	(	-LRB-
cord-021419-nypnib0h	623	50	113	113	CD
cord-021419-nypnib0h	623	51	)	)	-RRB-
cord-021419-nypnib0h	623	52	,	,	,
cord-021419-nypnib0h	623	53	5-(4methoxyphenyldiazenyl)olivomycin	5-(4methoxyphenyldiazenyl)olivomycin	CD
cord-021419-nypnib0h	623	54	(	(	-LRB-
cord-021419-nypnib0h	623	55	114	114	CD
cord-021419-nypnib0h	623	56	)	)	-RRB-
cord-021419-nypnib0h	623	57	,	,	,
cord-021419-nypnib0h	623	58	5-(3,4-dichlorophenyldiazenyl)olivomycin	5-(3,4-dichlorophenyldiazenyl)olivomycin	CD
cord-021419-nypnib0h	623	59	(	(	-LRB-
cord-021419-nypnib0h	623	60	115	115	CD
cord-021419-nypnib0h	623	61	)	)	-RRB-
cord-021419-nypnib0h	623	62	and	and	CC
cord-021419-nypnib0h	623	63	5-(4-methylphenyldiazenyl)olivomycin	5-(4-methylphenyldiazenyl)olivomycin	NNS
cord-021419-nypnib0h	623	64	(	(	-LRB-
cord-021419-nypnib0h	623	65	116	116	CD
cord-021419-nypnib0h	623	66	)	)	-RRB-
cord-021419-nypnib0h	623	67	(	(	-LRB-
cord-021419-nypnib0h	623	68	see	see	VB
cord-021419-nypnib0h	623	69	Scheme	Scheme	NNP
cord-021419-nypnib0h	623	70	31	31	CD
cord-021419-nypnib0h	623	71	)	)	-RRB-
cord-021419-nypnib0h	623	72	.	.	.
cord-021419-nypnib0h	624	1	72	72	CD
cord-021419-nypnib0h	625	1	To	to	TO
cord-021419-nypnib0h	625	2	explain	explain	VB
cord-021419-nypnib0h	625	3	the	the	DT
cord-021419-nypnib0h	625	4	outcome	outcome	NN
cord-021419-nypnib0h	625	5	of	of	IN
cord-021419-nypnib0h	625	6	this	this	DT
cord-021419-nypnib0h	625	7	reaction	reaction	NN
cord-021419-nypnib0h	625	8	,	,	,
cord-021419-nypnib0h	625	9	the	the	DT
cord-021419-nypnib0h	625	10	frontier	frontier	NN
cord-021419-nypnib0h	625	11	electron	electron	NN
cord-021419-nypnib0h	625	12	density	density	NN
cord-021419-nypnib0h	625	13	in	in	IN
cord-021419-nypnib0h	625	14	the	the	DT
cord-021419-nypnib0h	625	15	highest	high	JJS
cord-021419-nypnib0h	625	16	occupied	occupied	JJ
cord-021419-nypnib0h	625	17	molecular	molecular	JJ
cord-021419-nypnib0h	625	18	orbital	orbital	NN
cord-021419-nypnib0h	625	19	(	(	-LRB-
cord-021419-nypnib0h	625	20	HOMO	HOMO	NNP
cord-021419-nypnib0h	625	21	)	)	-RRB-
cord-021419-nypnib0h	625	22	was	be	VBD
cord-021419-nypnib0h	625	23	calculated	calculate	VBN
cord-021419-nypnib0h	625	24	by	by	IN
cord-021419-nypnib0h	625	25	the	the	DT
cord-021419-nypnib0h	625	26	semiempirical	semiempirical	JJ
cord-021419-nypnib0h	625	27	quantum	quantum	JJ
cord-021419-nypnib0h	625	28	chemical	chemical	NN
cord-021419-nypnib0h	625	29	AM1	AM1	NNP
cord-021419-nypnib0h	625	30	method	method	NN
cord-021419-nypnib0h	625	31	(	(	-LRB-
cord-021419-nypnib0h	625	32	Fukui	Fukui	NNP
cord-021419-nypnib0h	625	33	indices	index	NNS
cord-021419-nypnib0h	625	34	f	f	LS
cord-021419-nypnib0h	625	35	)	)	-RRB-
cord-021419-nypnib0h	625	36	.	.	.
cord-021419-nypnib0h	626	1	Alternative	alternative	JJ
cord-021419-nypnib0h	626	2	directions	direction	NNS
cord-021419-nypnib0h	626	3	of	of	IN
cord-021419-nypnib0h	626	4	the	the	DT
cord-021419-nypnib0h	626	5	nucleophilic	nucleophilic	JJ
cord-021419-nypnib0h	626	6	attack	attack	NN
cord-021419-nypnib0h	626	7	by	by	IN
cord-021419-nypnib0h	626	8	the	the	DT
cord-021419-nypnib0h	626	9	phenyldiazonium	phenyldiazonium	NNP
cord-021419-nypnib0h	626	10	cation	cation	NNP
cord-021419-nypnib0h	626	11	were	be	VBD
cord-021419-nypnib0h	626	12	chosen	choose	VBN
cord-021419-nypnib0h	626	13	by	by	IN
cord-021419-nypnib0h	626	14	considering	consider	VBG
cord-021419-nypnib0h	626	15	possible	possible	JJ
cord-021419-nypnib0h	626	16	anionic	anionic	JJ
cord-021419-nypnib0h	626	17	forms	form	NNS
cord-021419-nypnib0h	626	18	of	of	IN
cord-021419-nypnib0h	626	19	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	626	20	(	(	-LRB-
cord-021419-nypnib0h	626	21	110A	110A	NNP
cord-021419-nypnib0h	626	22	±	±	NNP
cord-021419-nypnib0h	626	23	110C	110c	CD
cord-021419-nypnib0h	626	24	)	)	-RRB-
cord-021419-nypnib0h	627	1	(	(	-LRB-
cord-021419-nypnib0h	627	2	Scheme	scheme	NN
cord-021419-nypnib0h	627	3	32	32	CD
cord-021419-nypnib0h	627	4	a	a	LS
cord-021419-nypnib0h	627	5	)	)	-RRB-
cord-021419-nypnib0h	627	6	.	.	.
cord-021419-nypnib0h	628	1	It	-PRON-	PRP
cord-021419-nypnib0h	628	2	was	be	VBD
cord-021419-nypnib0h	628	3	found	find	VBN
cord-021419-nypnib0h	628	4	that	that	IN
cord-021419-nypnib0h	628	5	the	the	DT
cord-021419-nypnib0h	628	6	5	5	CD
cord-021419-nypnib0h	628	7	position	position	NN
cord-021419-nypnib0h	628	8	in	in	IN
cord-021419-nypnib0h	628	9	anion	anion	NN
cord-021419-nypnib0h	628	10	110A	110a	CD
cord-021419-nypnib0h	628	11	is	be	VBZ
cord-021419-nypnib0h	628	12	the	the	DT
cord-021419-nypnib0h	628	13	most	most	RBS
cord-021419-nypnib0h	628	14	favourable	favourable	JJ
cord-021419-nypnib0h	628	15	for	for	IN
cord-021419-nypnib0h	628	16	electrophilic	electrophilic	JJ
cord-021419-nypnib0h	628	17	attack	attack	NN
cord-021419-nypnib0h	628	18	giving	give	VBG
cord-021419-nypnib0h	628	19	compound	compound	NN
cord-021419-nypnib0h	628	20	112	112	CD
cord-021419-nypnib0h	628	21	(	(	-LRB-
cord-021419-nypnib0h	628	22	the	the	DT
cord-021419-nypnib0h	628	23	Fukui	Fukui	NNP
cord-021419-nypnib0h	628	24	index	index	NN
cord-021419-nypnib0h	628	25	f	f	NNP
cord-021419-nypnib0h	628	26	HOMO	HOMO	NNP
cord-021419-nypnib0h	628	27	is	be	VBZ
cord-021419-nypnib0h	628	28	0.617	0.617	CD
cord-021419-nypnib0h	628	29	)	)	-RRB-
cord-021419-nypnib0h	628	30	.	.	.
cord-021419-nypnib0h	629	1	Meanwhile	meanwhile	RB
cord-021419-nypnib0h	629	2	,	,	,
cord-021419-nypnib0h	629	3	the	the	DT
cord-021419-nypnib0h	629	4	nucleophilicities	nucleophilicitie	NNS
cord-021419-nypnib0h	629	5	of	of	IN
cord-021419-nypnib0h	629	6	the	the	DT
cord-021419-nypnib0h	629	7	C(7	C(7	NNP
cord-021419-nypnib0h	629	8	)	)	-RRB-
cord-021419-nypnib0h	629	9	and	and	CC
cord-021419-nypnib0h	629	10	C(10	C(10	NNP
cord-021419-nypnib0h	629	11	)	)	-RRB-
cord-021419-nypnib0h	629	12	atoms	atom	NNS
cord-021419-nypnib0h	629	13	are	be	VBP
cord-021419-nypnib0h	629	14	lower	low	JJR
cord-021419-nypnib0h	629	15	(	(	-LRB-
cord-021419-nypnib0h	629	16	0.356	0.356	CD
cord-021419-nypnib0h	629	17	and	and	CC
cord-021419-nypnib0h	629	18	0.185	0.185	CD
cord-021419-nypnib0h	629	19	,	,	,
cord-021419-nypnib0h	629	20	respectively	respectively	RB
cord-021419-nypnib0h	629	21	)	)	-RRB-
cord-021419-nypnib0h	629	22	.	.	.
cord-021419-nypnib0h	630	1	The	the	DT
cord-021419-nypnib0h	630	2	formation	formation	NN
cord-021419-nypnib0h	630	3	of	of	IN
cord-021419-nypnib0h	630	4	anion	anion	NN
cord-021419-nypnib0h	630	5	110A	110a	CD
cord-021419-nypnib0h	630	6	in	in	IN
cord-021419-nypnib0h	630	7	an	an	DT
cord-021419-nypnib0h	630	8	alkaline	alkaline	JJ
cord-021419-nypnib0h	630	9	medium	medium	NN
cord-021419-nypnib0h	630	10	is	be	VBZ
cord-021419-nypnib0h	630	11	confirmed	confirm	VBN
cord-021419-nypnib0h	630	12	by	by	IN
cord-021419-nypnib0h	630	13	the	the	DT
cord-021419-nypnib0h	630	14	above	above	RB
cord-021419-nypnib0h	630	15	-	-	HYPH
cord-021419-nypnib0h	630	16	mentioned	mention	VBN
cord-021419-nypnib0h	630	17	selective	selective	JJ
cord-021419-nypnib0h	630	18	acylation	acylation	NN
cord-021419-nypnib0h	630	19	of	of	IN
cord-021419-nypnib0h	630	20	compound	compound	NN
cord-021419-nypnib0h	630	21	110	110	CD
cord-021419-nypnib0h	630	22	giving	give	VBG
cord-021419-nypnib0h	630	23	acetate	acetate	NN
cord-021419-nypnib0h	630	24	111	111	CD
cord-021419-nypnib0h	630	25	at	at	IN
cord-021419-nypnib0h	630	26	the	the	DT
cord-021419-nypnib0h	630	27	same	same	JJ
cord-021419-nypnib0h	630	28	hydroxyl	hydroxyl	NN
cord-021419-nypnib0h	630	29	group	group	NN
cord-021419-nypnib0h	630	30	at	at	IN
cord-021419-nypnib0h	630	31	the	the	DT
cord-021419-nypnib0h	630	32	C(8	C(8	NNP
cord-021419-nypnib0h	630	33	)	)	-RRB-
cord-021419-nypnib0h	630	34	atom	atom	NN
cord-021419-nypnib0h	630	35	in	in	IN
cord-021419-nypnib0h	630	36	high	high	JJ
cord-021419-nypnib0h	630	37	yield	yield	NN
cord-021419-nypnib0h	630	38	(	(	-LRB-
cord-021419-nypnib0h	630	39	see	see	VB
cord-021419-nypnib0h	630	40	Scheme	Scheme	NNP
cord-021419-nypnib0h	630	41	32	32	CD
cord-021419-nypnib0h	630	42	)	)	-RRB-
cord-021419-nypnib0h	630	43	.	.	.
cord-021419-nypnib0h	631	1	72	72	CD
cord-021419-nypnib0h	632	1	The	the	DT
cord-021419-nypnib0h	632	2	calculated	calculate	VBN
cord-021419-nypnib0h	632	3	energy	energy	NN
cord-021419-nypnib0h	632	4	parameters	parameter	NNS
cord-021419-nypnib0h	632	5	of	of	IN
cord-021419-nypnib0h	632	6	alkaline	alkaline	JJ
cord-021419-nypnib0h	632	7	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	632	8	of	of	IN
cord-021419-nypnib0h	632	9	the	the	DT
cord-021419-nypnib0h	632	10	disaccharide	disaccharide	JJ
cord-021419-nypnib0h	632	11	branch	branch	NN
cord-021419-nypnib0h	632	12	are	be	VBP
cord-021419-nypnib0h	632	13	in	in	IN
cord-021419-nypnib0h	632	14	agreement	agreement	NN
cord-021419-nypnib0h	632	15	with	with	IN
cord-021419-nypnib0h	632	16	the	the	DT
cord-021419-nypnib0h	632	17	experimental	experimental	JJ
cord-021419-nypnib0h	632	18	data	datum	NNS
cord-021419-nypnib0h	632	19	.	.	.
cord-021419-nypnib0h	633	1	Thus	thus	RB
cord-021419-nypnib0h	633	2	,	,	,
cord-021419-nypnib0h	633	3	the	the	DT
cord-021419-nypnib0h	633	4	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	633	5	proceeds	proceed	VBZ
cord-021419-nypnib0h	633	6	very	very	RB
cord-021419-nypnib0h	633	7	rapidly	rapidly	RB
cord-021419-nypnib0h	633	8	in	in	IN
cord-021419-nypnib0h	633	9	the	the	DT
cord-021419-nypnib0h	633	10	presence	presence	NN
cord-021419-nypnib0h	633	11	of	of	IN
cord-021419-nypnib0h	633	12	the	the	DT
cord-021419-nypnib0h	633	13	diazenyl	diazenyl	NNP
cord-021419-nypnib0h	633	14	substituent	substituent	NNP
cord-021419-nypnib0h	633	15	at	at	IN
cord-021419-nypnib0h	633	16	the	the	DT
cord-021419-nypnib0h	633	17	5	5	CD
cord-021419-nypnib0h	633	18	position	position	NN
cord-021419-nypnib0h	633	19	,	,	,
cord-021419-nypnib0h	633	20	while	while	IN
cord-021419-nypnib0h	633	21	the	the	DT
cord-021419-nypnib0h	633	22	storage	storage	NN
cord-021419-nypnib0h	633	23	of	of	IN
cord-021419-nypnib0h	633	24	110	110	CD
cord-021419-nypnib0h	633	25	in	in	IN
cord-021419-nypnib0h	633	26	an	an	DT
cord-021419-nypnib0h	633	27	alkaline	alkaline	JJ
cord-021419-nypnib0h	633	28	medium	medium	NN
cord-021419-nypnib0h	633	29	(	(	-LRB-
cord-021419-nypnib0h	633	30	used	use	VBN
cord-021419-nypnib0h	633	31	for	for	IN
cord-021419-nypnib0h	633	32	the	the	DT
cord-021419-nypnib0h	633	33	azo	azo	NN
cord-021419-nypnib0h	633	34	coupling	coupling	NN
cord-021419-nypnib0h	633	35	)	)	-RRB-
cord-021419-nypnib0h	633	36	on	on	IN
cord-021419-nypnib0h	633	37	cooling	cool	VBG
cord-021419-nypnib0h	633	38	to	to	IN
cord-021419-nypnib0h	633	39	0	0	CD
cord-021419-nypnib0h	633	40	±	±	CD
cord-021419-nypnib0h	633	41	5	5	CD
cord-021419-nypnib0h	633	42	8C	8c	CD
cord-021419-nypnib0h	633	43	for	for	IN
cord-021419-nypnib0h	633	44	2	2	CD
cord-021419-nypnib0h	633	45	h	h	NN
cord-021419-nypnib0h	633	46	in	in	IN
cord-021419-nypnib0h	633	47	the	the	DT
cord-021419-nypnib0h	633	48	absence	absence	NN
cord-021419-nypnib0h	633	49	of	of	IN
cord-021419-nypnib0h	633	50	diazonium	diazonium	NN
cord-021419-nypnib0h	633	51	salt	salt	NN
cord-021419-nypnib0h	633	52	does	do	VBZ
cord-021419-nypnib0h	633	53	not	not	RB
cord-021419-nypnib0h	633	54	lead	lead	VB
cord-021419-nypnib0h	633	55	to	to	IN
cord-021419-nypnib0h	633	56	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	633	57	.	.	.
cord-021419-nypnib0h	634	1	The	the	DT
cord-021419-nypnib0h	634	2	azo	azo	NN
cord-021419-nypnib0h	634	3	coupling	coupling	NN
cord-021419-nypnib0h	634	4	of	of	IN
cord-021419-nypnib0h	634	5	aryldiazonium	aryldiazonium	NN
cord-021419-nypnib0h	634	6	salts	salt	NNS
cord-021419-nypnib0h	634	7	with	with	IN
cord-021419-nypnib0h	634	8	the	the	DT
cord-021419-nypnib0h	634	9	aglycone	aglycone	NN
cord-021419-nypnib0h	634	10	of	of	IN
cord-021419-nypnib0h	634	11	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	634	12	Ð	Ð	NNP
cord-021419-nypnib0h	634	13	olivin	olivin	NNP
cord-021419-nypnib0h	634	14	(	(	-LRB-
cord-021419-nypnib0h	634	15	117	117	CD
cord-021419-nypnib0h	634	16	)	)	-RRB-
cord-021419-nypnib0h	634	17	,	,	,
cord-021419-nypnib0h	634	18	which	which	WDT
cord-021419-nypnib0h	634	19	was	be	VBD
cord-021419-nypnib0h	634	20	synthesized	synthesize	VBN
cord-021419-nypnib0h	634	21	by	by	IN
cord-021419-nypnib0h	634	22	quantitative	quantitative	JJ
cord-021419-nypnib0h	634	23	acid	acid	NN
cord-021419-nypnib0h	634	24	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	634	25	of	of	IN
cord-021419-nypnib0h	634	26	compound	compound	NN
cord-021419-nypnib0h	634	27	110	110	CD
cord-021419-nypnib0h	634	28	,	,	,
cord-021419-nypnib0h	634	29	was	be	VBD
cord-021419-nypnib0h	634	30	investigated	investigate	VBN
cord-021419-nypnib0h	634	31	.	.	.
cord-021419-nypnib0h	635	1	Aryldiazenyl	Aryldiazenyl	NNP
cord-021419-nypnib0h	635	2	derivatives	derivative	NNS
cord-021419-nypnib0h	635	3	of	of	IN
cord-021419-nypnib0h	635	4	olivin	olivin	NNP
cord-021419-nypnib0h	635	5	117a	117a	NNP
cord-021419-nypnib0h	635	6	±	±	NNP
cord-021419-nypnib0h	635	7	c	c	NN
cord-021419-nypnib0h	635	8	containing	contain	VBG
cord-021419-nypnib0h	635	9	the	the	DT
cord-021419-nypnib0h	635	10	same	same	JJ
cord-021419-nypnib0h	635	11	substituents	substituent	NNS
cord-021419-nypnib0h	635	12	as	as	IN
cord-021419-nypnib0h	635	13	compounds	compound	NNS
cord-021419-nypnib0h	635	14	112	112	CD
cord-021419-nypnib0h	635	15	,	,	,
cord-021419-nypnib0h	635	16	114	114	CD
cord-021419-nypnib0h	635	17	and	and	CC
cord-021419-nypnib0h	635	18	115	115	CD
cord-021419-nypnib0h	635	19	(	(	-LRB-
cord-021419-nypnib0h	635	20	Scheme	Scheme	NNP
cord-021419-nypnib0h	635	21	33	33	CD
cord-021419-nypnib0h	635	22	)	)	-RRB-
cord-021419-nypnib0h	635	23	were	be	VBD
cord-021419-nypnib0h	635	24	synthesized	synthesize	VBN
cord-021419-nypnib0h	635	25	.	.	.
cord-021419-nypnib0h	636	1	70	70	CD
cord-021419-nypnib0h	637	1	The	the	DT
cord-021419-nypnib0h	637	2	geometric	geometric	JJ
cord-021419-nypnib0h	637	3	configurations	configuration	NNS
cord-021419-nypnib0h	637	4	of	of	IN
cord-021419-nypnib0h	637	5	the	the	DT
cord-021419-nypnib0h	637	6	most	most	RBS
cord-021419-nypnib0h	637	7	probable	probable	JJ
cord-021419-nypnib0h	637	8	tautomeric	tautomeric	JJ
cord-021419-nypnib0h	637	9	structures	structure	NNS
cord-021419-nypnib0h	638	1	A	a	DT
cord-021419-nypnib0h	638	2	±	±	NN
cord-021419-nypnib0h	638	3	D	d	NN
cord-021419-nypnib0h	638	4	of	of	IN
cord-021419-nypnib0h	638	5	derivative	derivative	JJ
cord-021419-nypnib0h	638	6	117a	117a	NNPS
cord-021419-nypnib0h	638	7	were	be	VBD
cord-021419-nypnib0h	638	8	determined	determine	VBN
cord-021419-nypnib0h	638	9	(	(	-LRB-
cord-021419-nypnib0h	638	10	Scheme	scheme	NN
cord-021419-nypnib0h	638	11	34	34	CD
cord-021419-nypnib0h	638	12	)	)	-RRB-
cord-021419-nypnib0h	638	13	and	and	CC
cord-021419-nypnib0h	638	14	the	the	DT
cord-021419-nypnib0h	638	15	total	total	JJ
cord-021419-nypnib0h	638	16	energies	energy	NNS
cord-021419-nypnib0h	638	17	of	of	IN
cord-021419-nypnib0h	638	18	each	each	DT
cord-021419-nypnib0h	638	19	tautomeric	tautomeric	JJ
cord-021419-nypnib0h	638	20	form	form	NN
cord-021419-nypnib0h	638	21	were	be	VBD
cord-021419-nypnib0h	638	22	calculated	calculate	VBN
cord-021419-nypnib0h	638	23	by	by	IN
cord-021419-nypnib0h	638	24	the	the	DT
cord-021419-nypnib0h	638	25	density	density	NN
cord-021419-nypnib0h	638	26	functional	functional	JJ
cord-021419-nypnib0h	638	27	theory	theory	NN
cord-021419-nypnib0h	638	28	at	at	IN
cord-021419-nypnib0h	638	29	the	the	DT
cord-021419-nypnib0h	638	30	B3LYP/6	B3LYP/6	NNP
cord-021419-nypnib0h	638	31	-	-	HYPH
cord-021419-nypnib0h	638	32	31G(d	31G(d	NNP
cord-021419-nypnib0h	638	33	)	)	-RRB-
cord-021419-nypnib0h	638	34	level	level	NN
cord-021419-nypnib0h	638	35	of	of	IN
cord-021419-nypnib0h	638	36	theory	theory	NN
cord-021419-nypnib0h	638	37	.	.	.
cord-021419-nypnib0h	639	1	The	the	DT
cord-021419-nypnib0h	639	2	1	1	CD
cord-021419-nypnib0h	639	3	H	h	NN
cord-021419-nypnib0h	639	4	NMR	nmr	NN
cord-021419-nypnib0h	639	5	spectroscopic	spectroscopic	JJ
cord-021419-nypnib0h	639	6	data	datum	NNS
cord-021419-nypnib0h	639	7	also	also	RB
cord-021419-nypnib0h	639	8	indicate	indicate	VBP
cord-021419-nypnib0h	639	9	that	that	IN
cord-021419-nypnib0h	639	10	compounds	compound	NNS
cord-021419-nypnib0h	639	11	117a	117a	CD
cord-021419-nypnib0h	639	12	±	±	NNP
cord-021419-nypnib0h	639	13	c	c	NN
cord-021419-nypnib0h	639	14	exist	exist	VBP
cord-021419-nypnib0h	639	15	as	as	IN
cord-021419-nypnib0h	639	16	equilibrium	equilibrium	NN
cord-021419-nypnib0h	639	17	mixtures	mixture	NNS
cord-021419-nypnib0h	639	18	of	of	IN
cord-021419-nypnib0h	639	19	isomeric	isomeric	JJ
cord-021419-nypnib0h	639	20	forms	form	NNS
cord-021419-nypnib0h	639	21	A	a	DT
cord-021419-nypnib0h	640	1	±	±	NNP
cord-021419-nypnib0h	640	2	D.	D.	NNP
cord-021419-nypnib0h	640	3	The	the	DT
cord-021419-nypnib0h	640	4	reaction	reaction	NN
cord-021419-nypnib0h	640	5	of	of	IN
cord-021419-nypnib0h	640	6	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	640	7	(	(	-LRB-
cord-021419-nypnib0h	640	8	110	110	CD
cord-021419-nypnib0h	640	9	)	)	-RRB-
cord-021419-nypnib0h	640	10	with	with	IN
cord-021419-nypnib0h	640	11	(	(	-LRB-
cord-021419-nypnib0h	640	12	O	o	UH
cord-021419-nypnib0h	640	13	-	-	HYPH
cord-021419-nypnib0h	640	14	carboxymethyl)hydroxylamine	carboxymethyl)hydroxylamine	NNP
cord-021419-nypnib0h	640	15	affords	afford	VBZ
cord-021419-nypnib0h	640	16	2	2	CD
cord-021419-nypnib0h	640	17	H	h	NN
cord-021419-nypnib0h	640	18	-(carboxymethoxime)olivomycin	-(carboxymethoxime)olivomycin	NNS
cord-021419-nypnib0h	640	19	(	(	-LRB-
cord-021419-nypnib0h	640	20	CM	cm	NN
cord-021419-nypnib0h	640	21	)	)	-RRB-
cord-021419-nypnib0h	640	22	118	118	CD
cord-021419-nypnib0h	641	1	(	(	-LRB-
cord-021419-nypnib0h	641	2	Scheme	scheme	NN
cord-021419-nypnib0h	641	3	35	35	CD
cord-021419-nypnib0h	641	4	)	)	-RRB-
cord-021419-nypnib0h	641	5	.	.	.
cord-021419-nypnib0h	642	1	74	74	CD
cord-021419-nypnib0h	643	1	The	the	DT
cord-021419-nypnib0h	643	2	introduction	introduction	NN
cord-021419-nypnib0h	643	3	of	of	IN
cord-021419-nypnib0h	643	4	the	the	DT
cord-021419-nypnib0h	643	5	carboxyl	carboxyl	NN
cord-021419-nypnib0h	643	6	group	group	NN
cord-021419-nypnib0h	643	7	into	into	IN
cord-021419-nypnib0h	643	8	molecule	molecule	NN
cord-021419-nypnib0h	643	9	110	110	CD
cord-021419-nypnib0h	643	10	makes	make	VBZ
cord-021419-nypnib0h	643	11	it	-PRON-	PRP
cord-021419-nypnib0h	643	12	possible	possible	JJ
cord-021419-nypnib0h	643	13	to	to	TO
cord-021419-nypnib0h	643	14	subject	subject	VB
cord-021419-nypnib0h	643	15	this	this	DT
cord-021419-nypnib0h	643	16	compound	compound	NN
cord-021419-nypnib0h	643	17	to	to	IN
cord-021419-nypnib0h	643	18	further	further	JJ
cord-021419-nypnib0h	643	19	modification	modification	NN
cord-021419-nypnib0h	643	20	.	.	.
cord-021419-nypnib0h	644	1	The	the	DT
cord-021419-nypnib0h	644	2	reaction	reaction	NN
cord-021419-nypnib0h	644	3	of	of	IN
cord-021419-nypnib0h	644	4	compound	compound	NN
cord-021419-nypnib0h	644	5	118	118	CD
cord-021419-nypnib0h	644	6	with	with	IN
cord-021419-nypnib0h	644	7	appro-	appro-	NN
cord-021419-nypnib0h	644	8	75	75	CD
cord-021419-nypnib0h	645	1	The	the	DT
cord-021419-nypnib0h	645	2	introduction	introduction	NN
cord-021419-nypnib0h	645	3	of	of	IN
cord-021419-nypnib0h	645	4	the	the	DT
cord-021419-nypnib0h	645	5	carboxyl	carboxyl	NN
cord-021419-nypnib0h	645	6	group	group	NN
cord-021419-nypnib0h	645	7	into	into	IN
cord-021419-nypnib0h	645	8	molecule	molecule	NN
cord-021419-nypnib0h	645	9	110	110	CD
cord-021419-nypnib0h	645	10	,	,	,
cord-021419-nypnib0h	645	11	as	as	IN
cord-021419-nypnib0h	645	12	in	in	IN
cord-021419-nypnib0h	645	13	the	the	DT
cord-021419-nypnib0h	645	14	case	case	NN
cord-021419-nypnib0h	645	15	of	of	IN
cord-021419-nypnib0h	645	16	long	long	JJ
cord-021419-nypnib0h	645	17	acid	acid	NN
cord-021419-nypnib0h	645	18	118	118	CD
cord-021419-nypnib0h	645	19	,	,	,
cord-021419-nypnib0h	645	20	provides	provide	VBZ
cord-021419-nypnib0h	645	21	a	a	DT
cord-021419-nypnib0h	645	22	route	route	NN
cord-021419-nypnib0h	645	23	to	to	IN
cord-021419-nypnib0h	645	24	its	-PRON-	PRP$
cord-021419-nypnib0h	645	25	further	further	JJ
cord-021419-nypnib0h	645	26	modification	modification	NN
cord-021419-nypnib0h	645	27	.	.	.
cord-021419-nypnib0h	646	1	The	the	DT
cord-021419-nypnib0h	646	2	reaction	reaction	NN
cord-021419-nypnib0h	646	3	of	of	IN
cord-021419-nypnib0h	646	4	short	short	JJ
cord-021419-nypnib0h	646	5	OSA	OSA	NNP
cord-021419-nypnib0h	646	6	124	124	CD
cord-021419-nypnib0h	646	7	with	with	IN
cord-021419-nypnib0h	646	8	appropriate	appropriate	JJ
cord-021419-nypnib0h	646	9	amines	amine	NNS
cord-021419-nypnib0h	646	10	in	in	IN
cord-021419-nypnib0h	646	11	the	the	DT
cord-021419-nypnib0h	646	12	presence	presence	NN
cord-021419-nypnib0h	646	13	of	of	IN
cord-021419-nypnib0h	646	14	PyBOP	PyBOP	NNP
cord-021419-nypnib0h	646	15	or	or	CC
cord-021419-nypnib0h	646	16	diphenylphosphoryl	diphenylphosphoryl	NNP
cord-021419-nypnib0h	646	17	azide	azide	NN
cord-021419-nypnib0h	646	18	(	(	-LRB-
cord-021419-nypnib0h	646	19	DPPA	DPPA	NNP
cord-021419-nypnib0h	646	20	)	)	-RRB-
cord-021419-nypnib0h	646	21	affords	afford	VBZ
cord-021419-nypnib0h	646	22	OSA	OSA	NNP
cord-021419-nypnib0h	646	23	N	N	NNP
cord-021419-nypnib0h	646	24	-	-	HYPH
cord-021419-nypnib0h	646	25	methylamide	methylamide	NNP
cord-021419-nypnib0h	647	1	It	-PRON-	PRP
cord-021419-nypnib0h	647	2	is	be	VBZ
cord-021419-nypnib0h	647	3	worth	worth	JJ
cord-021419-nypnib0h	647	4	noting	note	VBG
cord-021419-nypnib0h	647	5	that	that	IN
cord-021419-nypnib0h	647	6	the	the	DT
cord-021419-nypnib0h	647	7	method	method	NN
cord-021419-nypnib0h	647	8	developed	develop	VBN
cord-021419-nypnib0h	647	9	for	for	IN
cord-021419-nypnib0h	647	10	the	the	DT
cord-021419-nypnib0h	647	11	synthesis	synthesis	NN
cord-021419-nypnib0h	647	12	of	of	IN
cord-021419-nypnib0h	647	13	intermediate	intermediate	JJ
cord-021419-nypnib0h	647	14	OSA	OSA	NNP
cord-021419-nypnib0h	647	15	(	(	-LRB-
cord-021419-nypnib0h	647	16	124	124	CD
cord-021419-nypnib0h	647	17	)	)	-RRB-
cord-021419-nypnib0h	647	18	can	can	MD
cord-021419-nypnib0h	647	19	be	be	VB
cord-021419-nypnib0h	647	20	applied	apply	VBN
cord-021419-nypnib0h	647	21	to	to	TO
cord-021419-nypnib0h	647	22	prepare	prepare	VB
cord-021419-nypnib0h	647	23	the	the	DT
cord-021419-nypnib0h	647	24	related	relate	VBN
cord-021419-nypnib0h	647	25	derivative	derivative	NN
cord-021419-nypnib0h	647	26	of	of	IN
cord-021419-nypnib0h	647	27	mithramycin	mithramycin	NNS
cord-021419-nypnib0h	647	28	bearing	bear	VBG
cord-021419-nypnib0h	647	29	a	a	DT
cord-021419-nypnib0h	647	30	similar	similar	JJ
cord-021419-nypnib0h	647	31	side	side	NN
cord-021419-nypnib0h	647	32	chain	chain	NN
cord-021419-nypnib0h	647	33	at	at	IN
cord-021419-nypnib0h	647	34	the	the	DT
cord-021419-nypnib0h	647	35	C(3	C(3	NNP
cord-021419-nypnib0h	647	36	)	)	-RRB-
cord-021419-nypnib0h	647	37	atom	atom	NN
cord-021419-nypnib0h	647	38	of	of	IN
cord-021419-nypnib0h	647	39	the	the	DT
cord-021419-nypnib0h	647	40	aglycone	aglycone	NN
cord-021419-nypnib0h	647	41	.	.	.
cord-021419-nypnib0h	648	1	Hence	hence	RB
cord-021419-nypnib0h	648	2	,	,	,
cord-021419-nypnib0h	648	3	short	short	JJ
cord-021419-nypnib0h	648	4	'	'	POS
cord-021419-nypnib0h	648	5	mithramycin	mithramycin	NN
cord-021419-nypnib0h	648	6	acid	acid	NN
cord-021419-nypnib0h	648	7	becomes	become	VBZ
cord-021419-nypnib0h	648	8	more	more	RBR
cord-021419-nypnib0h	648	9	available	available	JJ
cord-021419-nypnib0h	648	10	compared	compare	VBN
cord-021419-nypnib0h	648	11	to	to	IN
cord-021419-nypnib0h	648	12	the	the	DT
cord-021419-nypnib0h	648	13	combinatorial	combinatorial	JJ
cord-021419-nypnib0h	648	14	biosynthesis	biosynthesis	NN
cord-021419-nypnib0h	648	15	and	and	CC
cord-021419-nypnib0h	648	16	can	can	MD
cord-021419-nypnib0h	648	17	be	be	VB
cord-021419-nypnib0h	648	18	used	use	VBN
cord-021419-nypnib0h	648	19	for	for	IN
cord-021419-nypnib0h	648	20	further	further	JJ
cord-021419-nypnib0h	648	21	chemical	chemical	JJ
cord-021419-nypnib0h	648	22	modification	modification	NN
cord-021419-nypnib0h	648	23	of	of	IN
cord-021419-nypnib0h	648	24	mithramycin	mithramycin	NNS
cord-021419-nypnib0h	648	25	.	.	.
cord-021419-nypnib0h	649	1	76	76	CD
cord-021419-nypnib0h	649	2	 	 	_SP
cord-021419-nypnib0h	650	1	Olivomycin	Olivomycin	NNP
cord-021419-nypnib0h	650	2	A	A	NNP
cord-021419-nypnib0h	650	3	(	(	-LRB-
cord-021419-nypnib0h	650	4	110	110	CD
cord-021419-nypnib0h	650	5	)	)	-RRB-
cord-021419-nypnib0h	650	6	has	have	VBZ
cord-021419-nypnib0h	650	7	two	two	CD
cord-021419-nypnib0h	650	8	carbohydrate	carbohydrate	NN
cord-021419-nypnib0h	650	9	chains	chain	NNS
cord-021419-nypnib0h	650	10	bearing	bear	VBG
cord-021419-nypnib0h	650	11	the	the	DT
cord-021419-nypnib0h	650	12	acetyl	acetyl	NN
cord-021419-nypnib0h	650	13	group	group	NN
cord-021419-nypnib0h	650	14	at	at	IN
cord-021419-nypnib0h	650	15	the	the	DT
cord-021419-nypnib0h	650	16	A4	A4	NNP
cord-021419-nypnib0h	650	17	position	position	NN
cord-021419-nypnib0h	650	18	of	of	IN
cord-021419-nypnib0h	650	19	the	the	DT
cord-021419-nypnib0h	650	20	oliose	oliose	NNP
cord-021419-nypnib0h	650	21	moiety	moiety	NN
cord-021419-nypnib0h	650	22	and	and	CC
cord-021419-nypnib0h	650	23	the	the	DT
cord-021419-nypnib0h	650	24	isobutyryl	isobutyryl	NNP
cord-021419-nypnib0h	650	25	group	group	NN
cord-021419-nypnib0h	650	26	at	at	IN
cord-021419-nypnib0h	650	27	the	the	DT
cord-021419-nypnib0h	650	28	E4	E4	NNP
cord-021419-nypnib0h	650	29	position	position	NN
cord-021419-nypnib0h	650	30	of	of	IN
cord-021419-nypnib0h	650	31	the	the	DT
cord-021419-nypnib0h	650	32	olivomycose	olivomycose	JJ
cord-021419-nypnib0h	650	33	moiety	moiety	NN
cord-021419-nypnib0h	650	34	.	.	.
cord-021419-nypnib0h	651	1	A	a	DT
cord-021419-nypnib0h	651	2	series	series	NN
cord-021419-nypnib0h	651	3	of	of	IN
cord-021419-nypnib0h	651	4	analogues	analogue	NNS
cord-021419-nypnib0h	651	5	of	of	IN
cord-021419-nypnib0h	651	6	compound	compound	NN
cord-021419-nypnib0h	651	7	110	110	CD
cord-021419-nypnib0h	651	8	,	,	,
cord-021419-nypnib0h	651	9	which	which	WDT
cord-021419-nypnib0h	651	10	differ	differ	VBP
cord-021419-nypnib0h	651	11	in	in	IN
cord-021419-nypnib0h	651	12	the	the	DT
cord-021419-nypnib0h	651	13	set	set	NN
cord-021419-nypnib0h	651	14	of	of	IN
cord-021419-nypnib0h	651	15	functional	functional	JJ
cord-021419-nypnib0h	651	16	groups	group	NNS
cord-021419-nypnib0h	651	17	,	,	,
cord-021419-nypnib0h	651	18	were	be	VBD
cord-021419-nypnib0h	651	19	synthesized	synthesize	VBN
cord-021419-nypnib0h	651	20	in	in	IN
cord-021419-nypnib0h	651	21	order	order	NN
cord-021419-nypnib0h	651	22	to	to	TO
cord-021419-nypnib0h	651	23	elucidate	elucidate	VB
cord-021419-nypnib0h	651	24	the	the	DT
cord-021419-nypnib0h	651	25	influence	influence	NN
cord-021419-nypnib0h	651	26	of	of	IN
cord-021419-nypnib0h	651	27	acyl	acyl	NN
cord-021419-nypnib0h	651	28	substituents	substituent	NNS
cord-021419-nypnib0h	651	29	in	in	IN
cord-021419-nypnib0h	651	30	carbohydrate	carbohydrate	NN
cord-021419-nypnib0h	651	31	chains	chain	NNS
cord-021419-nypnib0h	651	32	on	on	IN
cord-021419-nypnib0h	651	33	biological	biological	JJ
cord-021419-nypnib0h	651	34	activity	activity	NN
cord-021419-nypnib0h	651	35	.	.	.
cord-021419-nypnib0h	652	1	77	77	CD
cord-021419-nypnib0h	653	1	Two	two	CD
cord-021419-nypnib0h	653	2	analogues	analogue	NNS
cord-021419-nypnib0h	653	3	,	,	,
cord-021419-nypnib0h	654	1	de	de	NNP
cord-021419-nypnib0h	654	2	-	-	NN
cord-021419-nypnib0h	654	3	E4-isobutyrylolivomycin	E4-isobutyrylolivomycin	NNP
cord-021419-nypnib0h	654	4	A	A	NNP
cord-021419-nypnib0h	654	5	(	(	-LRB-
cord-021419-nypnib0h	654	6	133	133	CD
cord-021419-nypnib0h	654	7	)	)	-RRB-
cord-021419-nypnib0h	654	8	and	and	CC
cord-021419-nypnib0h	655	1	de	de	LS
cord-021419-nypnib0h	655	2	-	-	JJ
cord-021419-nypnib0h	655	3	E4-isobutyryl	e4-isobutyryl	NN
cord-021419-nypnib0h	655	4	-	-	HYPH
cord-021419-nypnib0h	655	5	de	de	NN
cord-021419-nypnib0h	655	6	-	-	HYPH
cord-021419-nypnib0h	655	7	A4-acetylolivomycin	A4-acetylolivomycin	NNS
cord-021419-nypnib0h	655	8	A	A	NNP
cord-021419-nypnib0h	655	9	(	(	-LRB-
cord-021419-nypnib0h	655	10	or	or	CC
cord-021419-nypnib0h	655	11	de	de	JJ
cord-021419-nypnib0h	655	12	-	-	JJ
cord-021419-nypnib0h	655	13	E4isobutyrylolivomycin	e4isobutyrylolivomycin	JJ
cord-021419-nypnib0h	655	14	C	C	NNP
cord-021419-nypnib0h	655	15	)	)	-RRB-
cord-021419-nypnib0h	655	16	(	(	-LRB-
cord-021419-nypnib0h	655	17	134	134	CD
cord-021419-nypnib0h	655	18	)	)	-RRB-
cord-021419-nypnib0h	655	19	,	,	,
cord-021419-nypnib0h	655	20	were	be	VBD
cord-021419-nypnib0h	655	21	synthesized	synthesize	VBN
cord-021419-nypnib0h	655	22	by	by	IN
cord-021419-nypnib0h	655	23	selective	selective	JJ
cord-021419-nypnib0h	655	24	alkaline	alkaline	JJ
cord-021419-nypnib0h	655	25	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	655	26	of	of	IN
cord-021419-nypnib0h	655	27	the	the	DT
cord-021419-nypnib0h	655	28	E4-isobutyryl	E4-isobutyryl	NNP
cord-021419-nypnib0h	655	29	group	group	NN
cord-021419-nypnib0h	655	30	of	of	IN
cord-021419-nypnib0h	655	31	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	655	32	A	A	NNP
cord-021419-nypnib0h	655	33	(	(	-LRB-
cord-021419-nypnib0h	655	34	110	110	CD
cord-021419-nypnib0h	655	35	)	)	-RRB-
cord-021419-nypnib0h	655	36	or	or	CC
cord-021419-nypnib0h	655	37	C	C	NNP
cord-021419-nypnib0h	655	38	(	(	-LRB-
cord-021419-nypnib0h	655	39	135	135	CD
cord-021419-nypnib0h	655	40	)	)	-RRB-
cord-021419-nypnib0h	655	41	,	,	,
cord-021419-nypnib0h	655	42	respectively	respectively	RB
cord-021419-nypnib0h	655	43	(	(	-LRB-
cord-021419-nypnib0h	655	44	Scheme	scheme	NN
cord-021419-nypnib0h	655	45	37	37	CD
cord-021419-nypnib0h	655	46	)	)	-RRB-
cord-021419-nypnib0h	655	47	.	.	.
cord-021419-nypnib0h	656	1	It	-PRON-	PRP
cord-021419-nypnib0h	656	2	is	be	VBZ
cord-021419-nypnib0h	656	3	worth	worth	JJ
cord-021419-nypnib0h	656	4	noting	note	VBG
cord-021419-nypnib0h	656	5	that	that	IN
cord-021419-nypnib0h	656	6	the	the	DT
cord-021419-nypnib0h	656	7	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	656	8	of	of	IN
cord-021419-nypnib0h	656	9	the	the	DT
cord-021419-nypnib0h	656	10	E4-isobutyryl	E4-isobutyryl	NNP
cord-021419-nypnib0h	656	11	group	group	NN
cord-021419-nypnib0h	656	12	in	in	IN
cord-021419-nypnib0h	656	13	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	656	14	(	(	-LRB-
cord-021419-nypnib0h	656	15	110	110	CD
cord-021419-nypnib0h	656	16	)	)	-RRB-
cord-021419-nypnib0h	656	17	Antibiotics	antibiotic	NNS
cord-021419-nypnib0h	656	18	135	135	CD
cord-021419-nypnib0h	656	19	(	(	-LRB-
cord-021419-nypnib0h	656	20	de	de	NNP
cord-021419-nypnib0h	656	21	-	-	NN
cord-021419-nypnib0h	656	22	E4-isobutyrylolivomycin	E4-isobutyrylolivomycin	NNP
cord-021419-nypnib0h	656	23	A	A	NNP
cord-021419-nypnib0h	656	24	)	)	-RRB-
cord-021419-nypnib0h	656	25	and	and	CC
cord-021419-nypnib0h	656	26	136	136	CD
cord-021419-nypnib0h	657	1	(	(	-LRB-
cord-021419-nypnib0h	657	2	de	de	FW
cord-021419-nypnib0h	657	3	-	-	JJ
cord-021419-nypnib0h	657	4	E4-isobutyryl	e4-isobutyryl	NN
cord-021419-nypnib0h	657	5	-	-	HYPH
cord-021419-nypnib0h	657	6	E4-acetyl	e4-acetyl	NN
cord-021419-nypnib0h	657	7	-	-	HYPH
cord-021419-nypnib0h	657	8	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	657	9	A	a	NN
cord-021419-nypnib0h	657	10	or	or	CC
cord-021419-nypnib0h	657	11	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	657	12	B	b	NN
cord-021419-nypnib0h	657	13	)	)	-RRB-
cord-021419-nypnib0h	657	14	were	be	VBD
cord-021419-nypnib0h	657	15	isolated	isolate	VBN
cord-021419-nypnib0h	657	16	from	from	IN
cord-021419-nypnib0h	657	17	the	the	DT
cord-021419-nypnib0h	657	18	natural	natural	JJ
cord-021419-nypnib0h	657	19	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	657	20	complex	complex	NN
cord-021419-nypnib0h	657	21	produced	produce	VBN
cord-021419-nypnib0h	657	22	by	by	IN
cord-021419-nypnib0h	657	23	fermentation	fermentation	NN
cord-021419-nypnib0h	657	24	of	of	IN
cord-021419-nypnib0h	657	25	the	the	DT
cord-021419-nypnib0h	657	26	Streptoverticillum	Streptoverticillum	NNP
cord-021419-nypnib0h	657	27	cinnamoneum	cinnamoneum	NN
cord-021419-nypnib0h	657	28	strain	strain	NN
cord-021419-nypnib0h	657	29	.	.	.
cord-021419-nypnib0h	658	1	After	after	IN
cord-021419-nypnib0h	658	2	the	the	DT
cord-021419-nypnib0h	658	3	purification	purification	NN
cord-021419-nypnib0h	658	4	by	by	IN
cord-021419-nypnib0h	658	5	silica	silica	NN
cord-021419-nypnib0h	658	6	gel	gel	NN
cord-021419-nypnib0h	658	7	column	column	NN
cord-021419-nypnib0h	658	8	chromatography	chromatography	NN
cord-021419-nypnib0h	658	9	and	and	CC
cord-021419-nypnib0h	658	10	semipreparative	semipreparative	JJ
cord-021419-nypnib0h	658	11	HPLC	HPLC	NNP
cord-021419-nypnib0h	658	12	,	,	,
cord-021419-nypnib0h	658	13	compounds	compound	VBZ
cord-021419-nypnib0h	658	14	135	135	CD
cord-021419-nypnib0h	658	15	and	and	CC
cord-021419-nypnib0h	658	16	136	136	CD
cord-021419-nypnib0h	658	17	were	be	VBD
cord-021419-nypnib0h	658	18	isolated	isolate	VBN
cord-021419-nypnib0h	658	19	in	in	IN
cord-021419-nypnib0h	658	20	40	40	CD
cord-021419-nypnib0h	658	21	%	%	NN
cord-021419-nypnib0h	658	22	and	and	CC
cord-021419-nypnib0h	658	23	45	45	CD
cord-021419-nypnib0h	658	24	%	%	NN
cord-021419-nypnib0h	658	25	yields	yield	NNS
cord-021419-nypnib0h	658	26	,	,	,
cord-021419-nypnib0h	658	27	respectively	respectively	RB
cord-021419-nypnib0h	658	28	.	.	.
cord-021419-nypnib0h	659	1	70	70	CD
cord-021419-nypnib0h	659	2	,	,	,
cord-021419-nypnib0h	659	3	77	77	CD
cord-021419-nypnib0h	660	1	These	these	DT
cord-021419-nypnib0h	660	2	compounds	compound	NNS
cord-021419-nypnib0h	660	3	are	be	VBP
cord-021419-nypnib0h	660	4	identical	identical	JJ
cord-021419-nypnib0h	660	5	to	to	IN
cord-021419-nypnib0h	660	6	the	the	DT
cord-021419-nypnib0h	660	7	previously	previously	RB
cord-021419-nypnib0h	660	8	characterized	characterize	VBN
cord-021419-nypnib0h	660	9	natural	natural	JJ
cord-021419-nypnib0h	660	10	olivomycins	olivomycin	NNS
cord-021419-nypnib0h	660	11	C	C	NNP
cord-021419-nypnib0h	660	12	and	and	CC
cord-021419-nypnib0h	660	13	B	B	NNP
cord-021419-nypnib0h	660	14	,	,	,
cord-021419-nypnib0h	660	15	respectively	respectively	RB
cord-021419-nypnib0h	660	16	.	.	.
cord-021419-nypnib0h	661	1	78	78	CD
cord-021419-nypnib0h	662	1	The	the	DT
cord-021419-nypnib0h	662	2	modification	modification	NN
cord-021419-nypnib0h	662	3	of	of	IN
cord-021419-nypnib0h	662	4	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	662	5	110	110	CD
cord-021419-nypnib0h	662	6	at	at	IN
cord-021419-nypnib0h	662	7	the	the	DT
cord-021419-nypnib0h	662	8	C(8	C(8	NNP
cord-021419-nypnib0h	662	9	)	)	-RRB-
cord-021419-nypnib0h	662	10	phenol	phenol	NN
cord-021419-nypnib0h	662	11	group	group	NN
cord-021419-nypnib0h	662	12	of	of	IN
cord-021419-nypnib0h	662	13	the	the	DT
cord-021419-nypnib0h	662	14	aromatic	aromatic	JJ
cord-021419-nypnib0h	662	15	ring	ring	NN
cord-021419-nypnib0h	662	16	(	(	-LRB-
cord-021419-nypnib0h	662	17	compound	compound	NN
cord-021419-nypnib0h	662	18	111	111	CD
cord-021419-nypnib0h	662	19	)	)	-RRB-
cord-021419-nypnib0h	662	20	was	be	VBD
cord-021419-nypnib0h	662	21	found	find	VBN
cord-021419-nypnib0h	662	22	to	to	TO
cord-021419-nypnib0h	662	23	have	have	VB
cord-021419-nypnib0h	662	24	no	no	DT
cord-021419-nypnib0h	662	25	effect	effect	NN
cord-021419-nypnib0h	662	26	on	on	IN
cord-021419-nypnib0h	662	27	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	662	28	activity	activity	NN
cord-021419-nypnib0h	662	29	against	against	IN
cord-021419-nypnib0h	662	30	cancer	cancer	NN
cord-021419-nypnib0h	662	31	cell	cell	NN
cord-021419-nypnib0h	662	32	lines	line	NNS
cord-021419-nypnib0h	662	33	and	and	CC
cord-021419-nypnib0h	662	34	does	do	VBZ
cord-021419-nypnib0h	662	35	not	not	RB
cord-021419-nypnib0h	662	36	alter	alter	VB
cord-021419-nypnib0h	662	37	its	-PRON-	PRP$
cord-021419-nypnib0h	662	38	ability	ability	NN
cord-021419-nypnib0h	662	39	to	to	TO
cord-021419-nypnib0h	662	40	inhibit	inhibit	VB
cord-021419-nypnib0h	662	41	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	662	42	I.	I.	NNP
cord-021419-nypnib0h	662	43	72	72	CD
cord-021419-nypnib0h	663	1	The	the	DT
cord-021419-nypnib0h	663	2	transformation	transformation	NN
cord-021419-nypnib0h	663	3	of	of	IN
cord-021419-nypnib0h	663	4	110	110	CD
cord-021419-nypnib0h	663	5	giving	give	VBG
cord-021419-nypnib0h	663	6	diazenyl	diazenyl	JJ
cord-021419-nypnib0h	663	7	derivatives	derivative	NNS
cord-021419-nypnib0h	663	8	accompanied	accompany	VBN
cord-021419-nypnib0h	663	9	by	by	IN
cord-021419-nypnib0h	663	10	elimination	elimination	NN
cord-021419-nypnib0h	663	11	of	of	IN
cord-021419-nypnib0h	663	12	the	the	DT
cord-021419-nypnib0h	663	13	disaccharide	disaccharide	JJ
cord-021419-nypnib0h	663	14	branch	branch	NN
cord-021419-nypnib0h	663	15	from	from	IN
cord-021419-nypnib0h	663	16	the	the	DT
cord-021419-nypnib0h	663	17	aglycone	aglycone	NNP
cord-021419-nypnib0h	663	18	(	(	-LRB-
cord-021419-nypnib0h	663	19	compounds	compound	NNS
cord-021419-nypnib0h	663	20	112	112	CD
cord-021419-nypnib0h	663	21	±	±	CD
cord-021419-nypnib0h	663	22	116	116	CD
cord-021419-nypnib0h	663	23	)	)	-RRB-
cord-021419-nypnib0h	663	24	leads	lead	VBZ
cord-021419-nypnib0h	663	25	to	to	IN
cord-021419-nypnib0h	663	26	a	a	DT
cord-021419-nypnib0h	663	27	sharp	sharp	JJ
cord-021419-nypnib0h	663	28	decrease	decrease	NN
cord-021419-nypnib0h	663	29	in	in	IN
cord-021419-nypnib0h	663	30	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	663	31	activity	activity	NN
cord-021419-nypnib0h	663	32	.	.	.
cord-021419-nypnib0h	664	1	Compared	compare	VBN
cord-021419-nypnib0h	664	2	to	to	IN
cord-021419-nypnib0h	664	3	the	the	DT
cord-021419-nypnib0h	664	4	starting	start	VBG
cord-021419-nypnib0h	664	5	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	664	6	110	110	CD
cord-021419-nypnib0h	664	7	,	,	,
cord-021419-nypnib0h	664	8	compounds	compound	VBZ
cord-021419-nypnib0h	664	9	112	112	CD
cord-021419-nypnib0h	664	10	,	,	,
cord-021419-nypnib0h	664	11	115	115	CD
cord-021419-nypnib0h	664	12	and	and	CC
cord-021419-nypnib0h	664	13	116	116	CD
cord-021419-nypnib0h	664	14	acquire	acquire	VBP
cord-021419-nypnib0h	664	15	considerable	considerable	JJ
cord-021419-nypnib0h	664	16	selective	selective	JJ
cord-021419-nypnib0h	664	17	activity	activity	NN
cord-021419-nypnib0h	664	18	against	against	IN
cord-021419-nypnib0h	664	19	human	human	JJ
cord-021419-nypnib0h	664	20	immunodeficiency	immunodeficiency	NN
cord-021419-nypnib0h	664	21	viruses	viruse	VBZ
cord-021419-nypnib0h	664	22	HIV-1	HIV-1	NNP
cord-021419-nypnib0h	664	23	and	and	CC
cord-021419-nypnib0h	664	24	HIV-2	HIV-2	NNP
cord-021419-nypnib0h	664	25	in	in	IN
cord-021419-nypnib0h	664	26	assays	assay	NNS
cord-021419-nypnib0h	664	27	in	in	IN
cord-021419-nypnib0h	664	28	the	the	DT
cord-021419-nypnib0h	664	29	human	human	JJ
cord-021419-nypnib0h	664	30	T	t	NN
cord-021419-nypnib0h	664	31	-	-	HYPH
cord-021419-nypnib0h	664	32	lymphocyte	lymphocyte	NN
cord-021419-nypnib0h	664	33	cell	cell	NN
cord-021419-nypnib0h	664	34	line	line	NN
cord-021419-nypnib0h	664	35	(	(	-LRB-
cord-021419-nypnib0h	664	36	CEM	CEM	NNP
cord-021419-nypnib0h	664	37	)	)	-RRB-
cord-021419-nypnib0h	664	38	.	.	.
cord-021419-nypnib0h	665	1	72	72	CD
cord-021419-nypnib0h	666	1	The	the	DT
cord-021419-nypnib0h	666	2	evaluation	evaluation	NN
cord-021419-nypnib0h	666	3	of	of	IN
cord-021419-nypnib0h	666	4	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	666	5	activity	activity	NN
cord-021419-nypnib0h	666	6	of	of	IN
cord-021419-nypnib0h	666	7	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	666	8	(	(	-LRB-
cord-021419-nypnib0h	666	9	110	110	CD
cord-021419-nypnib0h	666	10	)	)	-RRB-
cord-021419-nypnib0h	666	11	and	and	CC
cord-021419-nypnib0h	666	12	its	-PRON-	PRP$
cord-021419-nypnib0h	666	13	analogues	analogue	NNS
cord-021419-nypnib0h	666	14	modified	modify	VBN
cord-021419-nypnib0h	666	15	at	at	IN
cord-021419-nypnib0h	666	16	the	the	DT
cord-021419-nypnib0h	666	17	side	side	NN
cord-021419-nypnib0h	666	18	-	-	HYPH
cord-021419-nypnib0h	666	19	chain	chain	NN
cord-021419-nypnib0h	666	20	2	2	CD
cord-021419-nypnib0h	666	21	H	h	NN
cord-021419-nypnib0h	666	22	-keto	-keto	NN
cord-021419-nypnib0h	666	23	group	group	NN
cord-021419-nypnib0h	666	24	of	of	IN
cord-021419-nypnib0h	666	25	the	the	DT
cord-021419-nypnib0h	666	26	aglycone	aglycone	NNP
cord-021419-nypnib0h	666	27	(	(	-LRB-
cord-021419-nypnib0h	666	28	CM	CM	NNP
cord-021419-nypnib0h	666	29	amides	amide	NNS
cord-021419-nypnib0h	666	30	119	119	CD
cord-021419-nypnib0h	666	31	±	±	CD
cord-021419-nypnib0h	666	32	121	121	CD
cord-021419-nypnib0h	666	33	and	and	CC
cord-021419-nypnib0h	666	34	123	123	CD
cord-021419-nypnib0h	666	35	)	)	-RRB-
cord-021419-nypnib0h	666	36	against	against	IN
cord-021419-nypnib0h	666	37	the	the	DT
cord-021419-nypnib0h	666	38	leukaemia	leukaemia	NN
cord-021419-nypnib0h	666	39	cell	cell	NN
cord-021419-nypnib0h	666	40	lines	line	NNS
cord-021419-nypnib0h	666	41	K562	k562	XX
cord-021419-nypnib0h	666	42	and	and	CC
cord-021419-nypnib0h	666	43	L1210	L1210	NNP
cord-021419-nypnib0h	666	44	showed	show	VBD
cord-021419-nypnib0h	666	45	that	that	IN
cord-021419-nypnib0h	666	46	these	these	DT
cord-021419-nypnib0h	666	47	compounds	compound	NNS
cord-021419-nypnib0h	666	48	are	be	VBP
cord-021419-nypnib0h	666	49	more	more	RBR
cord-021419-nypnib0h	666	50	effective	effective	JJ
cord-021419-nypnib0h	666	51	than	than	IN
cord-021419-nypnib0h	666	52	the	the	DT
cord-021419-nypnib0h	666	53	starting	start	VBG
cord-021419-nypnib0h	666	54	acid	acid	NN
cord-021419-nypnib0h	666	55	118	118	CD
cord-021419-nypnib0h	666	56	but	but	CC
cord-021419-nypnib0h	666	57	are	be	VBP
cord-021419-nypnib0h	666	58	less	less	RBR
cord-021419-nypnib0h	666	59	active	active	JJ
cord-021419-nypnib0h	666	60	than	than	IN
cord-021419-nypnib0h	666	61	compound	compound	NN
cord-021419-nypnib0h	666	62	110	110	CD
cord-021419-nypnib0h	666	63	.	.	.
cord-021419-nypnib0h	667	1	74	74	CD
cord-021419-nypnib0h	668	1	For	for	IN
cord-021419-nypnib0h	668	2	derivatives	derivative	NNS
cord-021419-nypnib0h	668	3	of	of	IN
cord-021419-nypnib0h	668	4	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	668	5	110	110	CD
cord-021419-nypnib0h	668	6	with	with	IN
cord-021419-nypnib0h	668	7	a	a	DT
cord-021419-nypnib0h	668	8	shorter	short	JJR
cord-021419-nypnib0h	668	9	aglycone	aglycone	JJ
cord-021419-nypnib0h	668	10	side	side	NN
cord-021419-nypnib0h	668	11	chain	chain	NN
cord-021419-nypnib0h	668	12	(	(	-LRB-
cord-021419-nypnib0h	668	13	OSA	OSA	NNP
cord-021419-nypnib0h	668	14	,	,	,
cord-021419-nypnib0h	668	15	124	124	CD
cord-021419-nypnib0h	668	16	)	)	-RRB-
cord-021419-nypnib0h	668	17	and	and	CC
cord-021419-nypnib0h	668	18	its	-PRON-	PRP$
cord-021419-nypnib0h	668	19	amides	amide	NNS
cord-021419-nypnib0h	668	20	125	125	CD
cord-021419-nypnib0h	668	21	±	±	CD
cord-021419-nypnib0h	668	22	132	132	CD
cord-021419-nypnib0h	668	23	,	,	,
cord-021419-nypnib0h	668	24	the	the	DT
cord-021419-nypnib0h	668	25	evaluation	evaluation	NN
cord-021419-nypnib0h	668	26	of	of	IN
cord-021419-nypnib0h	668	27	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	668	28	activity	activity	NN
cord-021419-nypnib0h	668	29	in	in	IN
cord-021419-nypnib0h	668	30	the	the	DT
cord-021419-nypnib0h	668	31	human	human	JJ
cord-021419-nypnib0h	668	32	chronic	chronic	JJ
cord-021419-nypnib0h	668	33	myeloid	myeloid	NN
cord-021419-nypnib0h	668	34	leukaemia	leukaemia	NN
cord-021419-nypnib0h	668	35	cell	cell	NN
cord-021419-nypnib0h	668	36	line	line	NN
cord-021419-nypnib0h	668	37	K562	k562	XX
cord-021419-nypnib0h	668	38	and	and	CC
cord-021419-nypnib0h	668	39	the	the	DT
cord-021419-nypnib0h	668	40	human	human	JJ
cord-021419-nypnib0h	668	41	colon	colon	NN
cord-021419-nypnib0h	668	42	75	75	CD
cord-021419-nypnib0h	669	1	The	the	DT
cord-021419-nypnib0h	669	2	evaluation	evaluation	NN
cord-021419-nypnib0h	669	3	of	of	IN
cord-021419-nypnib0h	669	4	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	669	5	activity	activity	NN
cord-021419-nypnib0h	669	6	of	of	IN
cord-021419-nypnib0h	669	7	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	669	8	analogues	analogues	NNP
cord-021419-nypnib0h	669	9	133	133	CD
cord-021419-nypnib0h	669	10	±	±	CD
cord-021419-nypnib0h	669	11	136	136	CD
cord-021419-nypnib0h	669	12	against	against	IN
cord-021419-nypnib0h	669	13	HCT116	hct116	JJ
cord-021419-nypnib0h	669	14	cells	cell	NNS
cord-021419-nypnib0h	669	15	showed	show	VBD
cord-021419-nypnib0h	669	16	that	that	IN
cord-021419-nypnib0h	669	17	acyl	acyl	NN
cord-021419-nypnib0h	669	18	groups	group	NNS
cord-021419-nypnib0h	669	19	in	in	IN
cord-021419-nypnib0h	669	20	carbohydrate	carbohydrate	NN
cord-021419-nypnib0h	669	21	chains	chain	NNS
cord-021419-nypnib0h	669	22	of	of	IN
cord-021419-nypnib0h	669	23	antibiotic	antibiotic	NN
cord-021419-nypnib0h	669	24	110	110	CD
cord-021419-nypnib0h	669	25	play	play	NN
cord-021419-nypnib0h	669	26	a	a	DT
cord-021419-nypnib0h	669	27	significant	significant	JJ
cord-021419-nypnib0h	669	28	role	role	NN
cord-021419-nypnib0h	669	29	.	.	.
cord-021419-nypnib0h	670	1	The	the	DT
cord-021419-nypnib0h	670	2	activity	activity	NN
cord-021419-nypnib0h	670	3	decreases	decrease	VBZ
cord-021419-nypnib0h	670	4	with	with	IN
cord-021419-nypnib0h	670	5	elimination	elimination	NN
cord-021419-nypnib0h	670	6	of	of	IN
cord-021419-nypnib0h	670	7	acyl	acyl	NN
cord-021419-nypnib0h	670	8	groups	group	NNS
cord-021419-nypnib0h	670	9	from	from	IN
cord-021419-nypnib0h	670	10	molecule	molecule	NN
cord-021419-nypnib0h	670	11	110	110	CD
cord-021419-nypnib0h	670	12	;	;	:
cord-021419-nypnib0h	670	13	IC	IC	NNP
cord-021419-nypnib0h	670	14	50	50	CD
cord-021419-nypnib0h	670	15	is	be	VBZ
cord-021419-nypnib0h	670	16	0.02	0.02	CD
cord-021419-nypnib0h	670	17	(	(	-LRB-
cord-021419-nypnib0h	670	18	for	for	IN
cord-021419-nypnib0h	670	19	110	110	CD
cord-021419-nypnib0h	670	20	)	)	-RRB-
cord-021419-nypnib0h	670	21	,	,	,
cord-021419-nypnib0h	670	22	0.064	0.064	CD
cord-021419-nypnib0h	670	23	(	(	-LRB-
cord-021419-nypnib0h	670	24	for	for	IN
cord-021419-nypnib0h	670	25	136	136	CD
cord-021419-nypnib0h	670	26	)	)	-RRB-
cord-021419-nypnib0h	670	27	,	,	,
cord-021419-nypnib0h	670	28	0.28	0.28	CD
cord-021419-nypnib0h	670	29	(	(	-LRB-
cord-021419-nypnib0h	670	30	for	for	IN
cord-021419-nypnib0h	670	31	133	133	CD
cord-021419-nypnib0h	670	32	)	)	-RRB-
cord-021419-nypnib0h	670	33	and	and	CC
cord-021419-nypnib0h	670	34	>	>	XX
cord-021419-nypnib0h	670	35	50	50	CD
cord-021419-nypnib0h	670	36	mmol	mmol	JJ
cord-021419-nypnib0h	670	37	L	L	NNP
cord-021419-nypnib0h	670	38	71	71	CD
cord-021419-nypnib0h	670	39	(	(	-LRB-
cord-021419-nypnib0h	670	40	for	for	IN
cord-021419-nypnib0h	670	41	compounds	compound	NNS
cord-021419-nypnib0h	670	42	117	117	CD
cord-021419-nypnib0h	670	43	,	,	,
cord-021419-nypnib0h	670	44	134	134	CD
cord-021419-nypnib0h	670	45	and	and	CC
cord-021419-nypnib0h	670	46	135	135	CD
cord-021419-nypnib0h	670	47	)	)	-RRB-
cord-021419-nypnib0h	670	48	.	.	.
cord-021419-nypnib0h	671	1	77	77	CD
cord-021419-nypnib0h	672	1	These	these	DT
cord-021419-nypnib0h	672	2	results	result	NNS
cord-021419-nypnib0h	672	3	correlate	correlate	VBP
cord-021419-nypnib0h	672	4	with	with	IN
cord-021419-nypnib0h	672	5	the	the	DT
cord-021419-nypnib0h	672	6	data	datum	NNS
cord-021419-nypnib0h	672	7	on	on	IN
cord-021419-nypnib0h	672	8	the	the	DT
cord-021419-nypnib0h	672	9	ability	ability	NN
cord-021419-nypnib0h	672	10	of	of	IN
cord-021419-nypnib0h	672	11	these	these	DT
cord-021419-nypnib0h	672	12	compounds	compound	NNS
cord-021419-nypnib0h	672	13	to	to	TO
cord-021419-nypnib0h	672	14	inhibit	inhibit	VB
cord-021419-nypnib0h	672	15	DNA	dna	NN
cord-021419-nypnib0h	672	16	-	-	HYPH
cord-021419-nypnib0h	672	17	dependent	dependent	JJ
cord-021419-nypnib0h	672	18	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	672	19	I.	i.	NN
cord-021419-nypnib0h	672	20	79	79	CD
cord-021419-nypnib0h	673	1	In	in	IN
cord-021419-nypnib0h	673	2	the	the	DT
cord-021419-nypnib0h	673	3	absence	absence	NN
cord-021419-nypnib0h	673	4	of	of	IN
cord-021419-nypnib0h	673	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	673	6	,	,	,
cord-021419-nypnib0h	673	7	the	the	DT
cord-021419-nypnib0h	673	8	relaxation	relaxation	NN
cord-021419-nypnib0h	673	9	of	of	IN
cord-021419-nypnib0h	673	10	supercoiled	supercoiled	JJ
cord-021419-nypnib0h	673	11	(	(	-LRB-
cord-021419-nypnib0h	673	12	sc	sc	NNP
cord-021419-nypnib0h	673	13	)	)	-RRB-
cord-021419-nypnib0h	673	14	DNA	DNA	NNP
cord-021419-nypnib0h	673	15	leads	lead	VBZ
cord-021419-nypnib0h	673	16	to	to	IN
cord-021419-nypnib0h	673	17	the	the	DT
cord-021419-nypnib0h	673	18	disappearance	disappearance	NN
cord-021419-nypnib0h	673	19	of	of	IN
cord-021419-nypnib0h	673	20	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	673	21	activity	activity	NN
cord-021419-nypnib0h	673	22	and	and	CC
cord-021419-nypnib0h	673	23	the	the	DT
cord-021419-nypnib0h	673	24	formation	formation	NN
cord-021419-nypnib0h	673	25	of	of	IN
cord-021419-nypnib0h	673	26	a	a	DT
cord-021419-nypnib0h	673	27	set	set	NN
cord-021419-nypnib0h	673	28	of	of	IN
cord-021419-nypnib0h	673	29	topoisomers	topoisomer	NNS
cord-021419-nypnib0h	673	30	.	.	.
cord-021419-nypnib0h	674	1	The	the	DT
cord-021419-nypnib0h	674	2	inhibition	inhibition	NN
cord-021419-nypnib0h	674	3	of	of	IN
cord-021419-nypnib0h	674	4	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	674	5	I	-PRON-	PRP
cord-021419-nypnib0h	674	6	is	be	VBZ
cord-021419-nypnib0h	674	7	detected	detect	VBN
cord-021419-nypnib0h	674	8	from	from	IN
cord-021419-nypnib0h	674	9	the	the	DT
cord-021419-nypnib0h	674	10	presence	presence	NN
cord-021419-nypnib0h	674	11	of	of	IN
cord-021419-nypnib0h	674	12	residual	residual	JJ
cord-021419-nypnib0h	674	13	amounts	amount	NNS
cord-021419-nypnib0h	674	14	of	of	IN
cord-021419-nypnib0h	674	15	sc	sc	JJ
cord-021419-nypnib0h	674	16	-	-	JJ
cord-021419-nypnib0h	674	17	DNA	DNA	NNP
cord-021419-nypnib0h	674	18	and	and	CC
cord-021419-nypnib0h	674	19	a	a	DT
cord-021419-nypnib0h	674	20	decrease	decrease	NN
cord-021419-nypnib0h	674	21	in	in	IN
cord-021419-nypnib0h	674	22	the	the	DT
cord-021419-nypnib0h	674	23	amount	amount	NN
cord-021419-nypnib0h	674	24	of	of	IN
cord-021419-nypnib0h	674	25	rapidly	rapidly	RB
cord-021419-nypnib0h	674	26	migrating	migrate	VBG
cord-021419-nypnib0h	674	27	topoisomers	topoisomer	NNS
cord-021419-nypnib0h	674	28	.	.	.
cord-021419-nypnib0h	675	1	A	a	DT
cord-021419-nypnib0h	675	2	decrease	decrease	NN
cord-021419-nypnib0h	675	3	in	in	IN
cord-021419-nypnib0h	675	4	the	the	DT
cord-021419-nypnib0h	675	5	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	675	6	activity	activity	NN
cord-021419-nypnib0h	675	7	of	of	IN
cord-021419-nypnib0h	675	8	the	the	DT
cord-021419-nypnib0h	675	9	enzyme	enzyme	NN
cord-021419-nypnib0h	675	10	is	be	VBZ
cord-021419-nypnib0h	675	11	consistent	consistent	JJ
cord-021419-nypnib0h	675	12	with	with	IN
cord-021419-nypnib0h	675	13	a	a	DT
cord-021419-nypnib0h	675	14	decrease	decrease	NN
cord-021419-nypnib0h	675	15	in	in	IN
cord-021419-nypnib0h	675	16	the	the	DT
cord-021419-nypnib0h	675	17	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	675	18	activity	activity	NN
cord-021419-nypnib0h	675	19	in	in	IN
cord-021419-nypnib0h	675	20	the	the	DT
cord-021419-nypnib0h	675	21	series	series	NN
cord-021419-nypnib0h	675	22	of	of	IN
cord-021419-nypnib0h	675	23	compounds	compound	NNS
cord-021419-nypnib0h	675	24	110	110	CD
cord-021419-nypnib0h	675	25	>	>	SYM
cord-021419-nypnib0h	675	26	136	136	CD
cord-021419-nypnib0h	675	27	>	>	SYM
cord-021419-nypnib0h	675	28	133	133	CD
cord-021419-nypnib0h	675	29	.	.	.
cord-021419-nypnib0h	676	1	The	the	DT
cord-021419-nypnib0h	676	2	removal	removal	NN
cord-021419-nypnib0h	676	3	of	of	IN
cord-021419-nypnib0h	676	4	the	the	DT
cord-021419-nypnib0h	676	5	E4-isobutyryl	E4-isobutyryl	NNP
cord-021419-nypnib0h	676	6	group	group	NN
cord-021419-nypnib0h	676	7	from	from	IN
cord-021419-nypnib0h	676	8	the	the	DT
cord-021419-nypnib0h	676	9	trisaccharide	trisaccharide	NNP
cord-021419-nypnib0h	676	10	branch	branch	NN
cord-021419-nypnib0h	676	11	has	have	VBZ
cord-021419-nypnib0h	676	12	a	a	DT
cord-021419-nypnib0h	676	13	lower	low	JJR
cord-021419-nypnib0h	676	14	effect	effect	NN
cord-021419-nypnib0h	676	15	than	than	IN
cord-021419-nypnib0h	676	16	the	the	DT
cord-021419-nypnib0h	676	17	removal	removal	NN
cord-021419-nypnib0h	676	18	of	of	IN
cord-021419-nypnib0h	676	19	the	the	DT
cord-021419-nypnib0h	676	20	A4-acetyl	A4-acetyl	NNP
cord-021419-nypnib0h	676	21	group	group	NN
cord-021419-nypnib0h	676	22	from	from	IN
cord-021419-nypnib0h	676	23	the	the	DT
cord-021419-nypnib0h	676	24	disaccharide	disaccharide	JJ
cord-021419-nypnib0h	676	25	branch	branch	NN
cord-021419-nypnib0h	676	26	.	.	.
cord-021419-nypnib0h	677	1	A	a	DT
cord-021419-nypnib0h	677	2	similar	similar	JJ
cord-021419-nypnib0h	677	3	pattern	pattern	NN
cord-021419-nypnib0h	677	4	of	of	IN
cord-021419-nypnib0h	677	5	activity	activity	NN
cord-021419-nypnib0h	677	6	is	be	VBZ
cord-021419-nypnib0h	677	7	observed	observe	VBN
cord-021419-nypnib0h	677	8	in	in	IN
cord-021419-nypnib0h	677	9	another	another	DT
cord-021419-nypnib0h	677	10	group	group	NN
cord-021419-nypnib0h	677	11	of	of	IN
cord-021419-nypnib0h	677	12	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	677	13	derivatives	derivative	NNS
cord-021419-nypnib0h	677	14	.	.	.
cord-021419-nypnib0h	678	1	Compound	compound	NN
cord-021419-nypnib0h	678	2	118	118	CD
cord-021419-nypnib0h	678	3	displays	display	NNS
cord-021419-nypnib0h	678	4	low	low	JJ
cord-021419-nypnib0h	678	5	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	678	6	activity	activity	NN
cord-021419-nypnib0h	678	7	and	and	CC
cord-021419-nypnib0h	678	8	is	be	VBZ
cord-021419-nypnib0h	678	9	inactive	inactive	JJ
cord-021419-nypnib0h	678	10	against	against	IN
cord-021419-nypnib0h	678	11	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	678	12	I.	i.	NN
cord-021419-nypnib0h	678	13	2	2	CD
cord-021419-nypnib0h	678	14	H	h	NN
cord-021419-nypnib0h	679	1	-(Carboxymethoxime)olivomycin	-(Carboxymethoxime)olivomycin	NNP
cord-021419-nypnib0h	680	1	N-(2-adamantyl)amide	n-(2-adamantyl)amide	RB
cord-021419-nypnib0h	681	1	(	(	-LRB-
cord-021419-nypnib0h	681	2	121	121	CD
cord-021419-nypnib0h	681	3	)	)	-RRB-
cord-021419-nypnib0h	681	4	is	be	VBZ
cord-021419-nypnib0h	681	5	active	active	JJ
cord-021419-nypnib0h	681	6	in	in	IN
cord-021419-nypnib0h	681	7	both	both	DT
cord-021419-nypnib0h	681	8	assays	assay	NNS
cord-021419-nypnib0h	681	9	.	.	.
cord-021419-nypnib0h	682	1	2	2	LS
cord-021419-nypnib0h	682	2	H	h	NN
cord-021419-nypnib0h	682	3	-(Carboxymethoxime)olivomycin	-(carboxymethoxime)olivomycin	NN
cord-021419-nypnib0h	682	4	N-(tert	N-(tert	NNP
cord-021419-nypnib0h	682	5	-	-	HYPH
cord-021419-nypnib0h	682	6	butyl)amide	butyl)amide	NNP
cord-021419-nypnib0h	682	7	(	(	-LRB-
cord-021419-nypnib0h	682	8	122	122	CD
cord-021419-nypnib0h	682	9	)	)	-RRB-
cord-021419-nypnib0h	682	10	and	and	CC
cord-021419-nypnib0h	682	11	2	2	CD
cord-021419-nypnib0h	682	12	H	h	NN
cord-021419-nypnib0h	682	13	-(carboxymethoxime)olivomycin	-(carboxymethoxime)olivomycin	VBZ
cord-021419-nypnib0h	682	14	N-(1,3-dihydroxy-2-methylpropan-2-yl)amide	n-(1,3-dihydroxy-2-methylpropan-2-yl)amide	NN
cord-021419-nypnib0h	682	15	(	(	-LRB-
cord-021419-nypnib0h	682	16	123	123	CD
cord-021419-nypnib0h	682	17	)	)	-RRB-
cord-021419-nypnib0h	682	18	are	be	VBP
cord-021419-nypnib0h	682	19	even	even	RB
cord-021419-nypnib0h	682	20	more	more	RBR
cord-021419-nypnib0h	682	21	effective	effective	JJ
cord-021419-nypnib0h	682	22	inhibitors	inhibitor	NNS
cord-021419-nypnib0h	682	23	of	of	IN
cord-021419-nypnib0h	682	24	the	the	DT
cord-021419-nypnib0h	682	25	enzyme	enzyme	NN
cord-021419-nypnib0h	682	26	,	,	,
cord-021419-nypnib0h	682	27	capable	capable	JJ
cord-021419-nypnib0h	682	28	of	of	IN
cord-021419-nypnib0h	682	29	inhibiting	inhibit	VBG
cord-021419-nypnib0h	682	30	sc	sc	JJ
cord-021419-nypnib0h	682	31	-	-	JJ
cord-021419-nypnib0h	682	32	DNA	dna	NN
cord-021419-nypnib0h	682	33	relaxation	relaxation	NN
cord-021419-nypnib0h	682	34	even	even	RB
cord-021419-nypnib0h	682	35	at	at	IN
cord-021419-nypnib0h	682	36	concentrations	concentration	NNS
cord-021419-nypnib0h	682	37	of	of	IN
cord-021419-nypnib0h	682	38	0.1	0.1	CD
cord-021419-nypnib0h	682	39	mmol	mmol	NN
cord-021419-nypnib0h	682	40	L	L	NNP
cord-021419-nypnib0h	682	41	71	71	CD
cord-021419-nypnib0h	682	42	.	.	.
cord-021419-nypnib0h	683	1	74	74	CD
cord-021419-nypnib0h	684	1	The	the	DT
cord-021419-nypnib0h	684	2	data	datum	NNS
cord-021419-nypnib0h	684	3	on	on	IN
cord-021419-nypnib0h	684	4	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	684	5	activity	activity	NN
cord-021419-nypnib0h	684	6	of	of	IN
cord-021419-nypnib0h	684	7	some	some	DT
cord-021419-nypnib0h	684	8	analogues	analogue	NNS
cord-021419-nypnib0h	684	9	of	of	IN
cord-021419-nypnib0h	684	10	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	684	11	110	110	CD
cord-021419-nypnib0h	684	12	do	do	VBP
cord-021419-nypnib0h	684	13	not	not	RB
cord-021419-nypnib0h	684	14	correlate	correlate	VB
cord-021419-nypnib0h	684	15	with	with	IN
cord-021419-nypnib0h	684	16	the	the	DT
cord-021419-nypnib0h	684	17	activity	activity	NN
cord-021419-nypnib0h	684	18	against	against	IN
cord-021419-nypnib0h	684	19	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	684	20	I.	i.	NN
cord-021419-nypnib0h	685	1	For	for	IN
cord-021419-nypnib0h	685	2	example	example	NN
cord-021419-nypnib0h	685	3	,	,	,
cord-021419-nypnib0h	685	4	the	the	DT
cord-021419-nypnib0h	685	5	analogue	analogue	NN
cord-021419-nypnib0h	685	6	of	of	IN
cord-021419-nypnib0h	685	7	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	685	8	OSA	OSA	NNP
cord-021419-nypnib0h	685	9	(	(	-LRB-
cord-021419-nypnib0h	685	10	124	124	CD
cord-021419-nypnib0h	685	11	)	)	-RRB-
cord-021419-nypnib0h	685	12	,	,	,
cord-021419-nypnib0h	685	13	which	which	WDT
cord-021419-nypnib0h	685	14	exhibits	exhibit	VBZ
cord-021419-nypnib0h	685	15	weak	weak	JJ
cord-021419-nypnib0h	685	16	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	685	17	activity	activity	NN
cord-021419-nypnib0h	685	18	,	,	,
cord-021419-nypnib0h	685	19	displays	display	VBZ
cord-021419-nypnib0h	685	20	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	685	21	activity	activity	NN
cord-021419-nypnib0h	685	22	against	against	IN
cord-021419-nypnib0h	685	23	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	685	24	I	-PRON-	PRP
cord-021419-nypnib0h	685	25	similar	similar	JJ
cord-021419-nypnib0h	685	26	to	to	IN
cord-021419-nypnib0h	685	27	that	that	DT
cord-021419-nypnib0h	685	28	of	of	IN
cord-021419-nypnib0h	685	29	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	685	30	A	A	NNP
cord-021419-nypnib0h	685	31	(	(	-LRB-
cord-021419-nypnib0h	685	32	110	110	CD
cord-021419-nypnib0h	685	33	)	)	-RRB-
cord-021419-nypnib0h	685	34	,	,	,
cord-021419-nypnib0h	685	35	whereas	whereas	IN
cord-021419-nypnib0h	685	36	DMAE	DMAE	NNP
cord-021419-nypnib0h	685	37	-	-	HYPH
cord-021419-nypnib0h	685	38	OSA	OSA	NNP
cord-021419-nypnib0h	685	39	(	(	-LRB-
cord-021419-nypnib0h	685	40	127	127	CD
cord-021419-nypnib0h	685	41	)	)	-RRB-
cord-021419-nypnib0h	685	42	possessing	possess	VBG
cord-021419-nypnib0h	685	43	high	high	JJ
cord-021419-nypnib0h	685	44	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	685	45	activity	activity	NN
cord-021419-nypnib0h	685	46	is	be	VBZ
cord-021419-nypnib0h	685	47	a	a	DT
cord-021419-nypnib0h	685	48	weaker	weak	JJR
cord-021419-nypnib0h	685	49	inhibitor	inhibitor	NN
cord-021419-nypnib0h	685	50	of	of	IN
cord-021419-nypnib0h	685	51	this	this	DT
cord-021419-nypnib0h	685	52	enzyme	enzyme	NN
cord-021419-nypnib0h	685	53	.	.	.
cord-021419-nypnib0h	686	1	74	74	CD
cord-021419-nypnib0h	686	2	,	,	,
cord-021419-nypnib0h	686	3	79	79	CD
cord-021419-nypnib0h	687	1	Recently	recently	RB
cord-021419-nypnib0h	687	2	,	,	,
cord-021419-nypnib0h	687	3	it	-PRON-	PRP
cord-021419-nypnib0h	687	4	was	be	VBD
cord-021419-nypnib0h	687	5	shown	show	VBN
cord-021419-nypnib0h	687	6	that	that	IN
cord-021419-nypnib0h	687	7	highly	highly	RB
cord-021419-nypnib0h	687	8	effective	effective	JJ
cord-021419-nypnib0h	687	9	analogue	analogue	NN
cord-021419-nypnib0h	687	10	127	127	CD
cord-021419-nypnib0h	687	11	can	can	MD
cord-021419-nypnib0h	687	12	act	act	VB
cord-021419-nypnib0h	687	13	as	as	IN
cord-021419-nypnib0h	687	14	a	a	DT
cord-021419-nypnib0h	687	15	DNA	dna	NN
cord-021419-nypnib0h	687	16	duplex	duplex	JJ
cord-021419-nypnib0h	687	17	minor	minor	JJ
cord-021419-nypnib0h	687	18	groove	groove	NN
cord-021419-nypnib0h	687	19	ligand	ligand	NN
cord-021419-nypnib0h	687	20	in	in	IN
cord-021419-nypnib0h	687	21	another	another	DT
cord-021419-nypnib0h	687	22	assay	assay	NN
cord-021419-nypnib0h	687	23	.	.	.
cord-021419-nypnib0h	688	1	It	-PRON-	PRP
cord-021419-nypnib0h	688	2	can	can	MD
cord-021419-nypnib0h	688	3	disrupt	disrupt	VB
cord-021419-nypnib0h	688	4	the	the	DT
cord-021419-nypnib0h	688	5	key	key	JJ
cord-021419-nypnib0h	688	6	epigenetic	epigenetic	JJ
cord-021419-nypnib0h	688	7	DNA	dna	NN
cord-021419-nypnib0h	688	8	methylation	methylation	NN
cord-021419-nypnib0h	688	9	process	process	NN
cord-021419-nypnib0h	688	10	with	with	IN
cord-021419-nypnib0h	688	11	the	the	DT
cord-021419-nypnib0h	688	12	Dnmt3a	Dnmt3a	NNP
cord-021419-nypnib0h	688	13	enzyme	enzyme	NN
cord-021419-nypnib0h	688	14	on	on	IN
cord-021419-nypnib0h	688	15	an	an	DT
cord-021419-nypnib0h	688	16	equal	equal	JJ
cord-021419-nypnib0h	688	17	basis	basis	NN
cord-021419-nypnib0h	688	18	with	with	IN
cord-021419-nypnib0h	688	19	antibiotic	antibiotic	NN
cord-021419-nypnib0h	688	20	110	110	CD
cord-021419-nypnib0h	688	21	.	.	.
cord-021419-nypnib0h	689	1	Both	both	DT
cord-021419-nypnib0h	689	2	compounds	compound	NNS
cord-021419-nypnib0h	689	3	inhibit	inhibit	VBP
cord-021419-nypnib0h	689	4	the	the	DT
cord-021419-nypnib0h	689	5	formation	formation	NN
cord-021419-nypnib0h	689	6	of	of	IN
cord-021419-nypnib0h	689	7	the	the	DT
cord-021419-nypnib0h	689	8	DNA	DNA	NNP
cord-021419-nypnib0h	689	9	±	±	NNP
cord-021419-nypnib0h	689	10	enzyme7intermediate	enzyme7intermediate	NNP
cord-021419-nypnib0h	689	11	covalent	covalent	JJ
cord-021419-nypnib0h	689	12	bond	bond	NN
cord-021419-nypnib0h	689	13	,	,	,
cord-021419-nypnib0h	689	14	required	require	VBN
cord-021419-nypnib0h	689	15	for	for	IN
cord-021419-nypnib0h	689	16	the	the	DT
cord-021419-nypnib0h	689	17	methylation	methylation	NN
cord-021419-nypnib0h	689	18	,	,	,
cord-021419-nypnib0h	689	19	at	at	IN
cord-021419-nypnib0h	689	20	nearly	nearly	RB
cord-021419-nypnib0h	689	21	equal	equal	JJ
cord-021419-nypnib0h	689	22	micromolar	micromolar	JJ
cord-021419-nypnib0h	689	23	concentrations	concentration	NNS
cord-021419-nypnib0h	689	24	.	.	.
cord-021419-nypnib0h	690	1	80	80	CD
cord-021419-nypnib0h	690	2	Olivomycin	Olivomycin	NNP
cord-021419-nypnib0h	690	3	complexes	complex	NNS
cord-021419-nypnib0h	690	4	with	with	IN
cord-021419-nypnib0h	690	5	model	model	NN
cord-021419-nypnib0h	690	6	oligonucleotide	oligonucleotide	VBN
cord-021419-nypnib0h	690	7	±	±	NNP
cord-021419-nypnib0h	690	8	DNA	DNA	NNP
cord-021419-nypnib0h	690	9	duplexes	duplex	NNS
cord-021419-nypnib0h	690	10	were	be	VBD
cord-021419-nypnib0h	690	11	studied	study	VBN
cord-021419-nypnib0h	690	12	by	by	IN
cord-021419-nypnib0h	690	13	circular	circular	JJ
cord-021419-nypnib0h	690	14	dichroism	dichroism	NN
cord-021419-nypnib0h	690	15	(	(	-LRB-
cord-021419-nypnib0h	690	16	CD	CD	NNP
cord-021419-nypnib0h	690	17	)	)	-RRB-
cord-021419-nypnib0h	690	18	and	and	CC
cord-021419-nypnib0h	690	19	fluorescence	fluorescence	NN
cord-021419-nypnib0h	690	20	titration	titration	NN
cord-021419-nypnib0h	690	21	(	(	-LRB-
cord-021419-nypnib0h	690	22	FT	FT	NNP
cord-021419-nypnib0h	690	23	)	)	-RRB-
cord-021419-nypnib0h	690	24	.	.	.
cord-021419-nypnib0h	691	1	According	accord	VBG
cord-021419-nypnib0h	691	2	to	to	IN
cord-021419-nypnib0h	691	3	Hartree	Hartree	NNP
cord-021419-nypnib0h	691	4	±	±	NNP
cord-021419-nypnib0h	691	5	Fock	Fock	NNP
cord-021419-nypnib0h	691	6	3	3	CD
cord-021419-nypnib0h	691	7	-	-	SYM
cord-021419-nypnib0h	691	8	21	21	CD
cord-021419-nypnib0h	691	9	G	g	NN
cord-021419-nypnib0h	691	10	calculations	calculation	NNS
cord-021419-nypnib0h	691	11	of	of	IN
cord-021419-nypnib0h	691	12	the	the	DT
cord-021419-nypnib0h	691	13	3D	3d	JJ
cord-021419-nypnib0h	691	14	structure	structure	NN
cord-021419-nypnib0h	691	15	of	of	IN
cord-021419-nypnib0h	691	16	the	the	DT
cord-021419-nypnib0h	691	17	dimer	dimer	NN
cord-021419-nypnib0h	691	18	[	[	-LRB-
cord-021419-nypnib0h	691	19	110	110	CD
cord-021419-nypnib0h	691	20	]	]	-RRB-
cord-021419-nypnib0h	691	21	2	2	CD
cord-021419-nypnib0h	691	22	Mg	Mg	NNP
cord-021419-nypnib0h	691	23	2	2	CD
cord-021419-nypnib0h	691	24	+	+	SYM
cord-021419-nypnib0h	691	25	,	,	,
cord-021419-nypnib0h	691	26	the	the	DT
cord-021419-nypnib0h	691	27	presence	presence	NN
cord-021419-nypnib0h	691	28	of	of	IN
cord-021419-nypnib0h	691	29	the	the	DT
cord-021419-nypnib0h	691	30	DMAE	DMAE	NNP
cord-021419-nypnib0h	691	31	group	group	NN
cord-021419-nypnib0h	691	32	in	in	IN
cord-021419-nypnib0h	691	33	compound	compound	NN
cord-021419-nypnib0h	691	34	127	127	CD
cord-021419-nypnib0h	691	35	leads	lead	VBZ
cord-021419-nypnib0h	691	36	to	to	IN
cord-021419-nypnib0h	691	37	an	an	DT
cord-021419-nypnib0h	691	38	increase	increase	NN
cord-021419-nypnib0h	691	39	in	in	IN
cord-021419-nypnib0h	691	40	the	the	DT
cord-021419-nypnib0h	691	41	binding	binding	JJ
cord-021419-nypnib0h	691	42	constant	constant	NN
cord-021419-nypnib0h	691	43	(	(	-LRB-
cord-021419-nypnib0h	691	44	K	K	NNP
cord-021419-nypnib0h	691	45	a	a	DT
cord-021419-nypnib0h	691	46	)	)	-RRB-
cord-021419-nypnib0h	691	47	of	of	IN
cord-021419-nypnib0h	691	48	the	the	DT
cord-021419-nypnib0h	691	49	Mg	Mg	NNP
cord-021419-nypnib0h	691	50	2	2	CD
cord-021419-nypnib0h	691	51	+	+	SYM
cord-021419-nypnib0h	691	52	complex	complex	JJ
cord-021419-nypnib0h	691	53	with	with	IN
cord-021419-nypnib0h	691	54	the	the	DT
cord-021419-nypnib0h	691	55	DNA	dna	NN
cord-021419-nypnib0h	691	56	duplex	duplex	NN
cord-021419-nypnib0h	691	57	by	by	IN
cord-021419-nypnib0h	691	58	an	an	DT
cord-021419-nypnib0h	691	59	order	order	NN
cord-021419-nypnib0h	691	60	of	of	IN
cord-021419-nypnib0h	691	61	magnitude	magnitude	NN
cord-021419-nypnib0h	691	62	compared	compare	VBN
cord-021419-nypnib0h	691	63	to	to	IN
cord-021419-nypnib0h	691	64	the	the	DT
cord-021419-nypnib0h	691	65	acid	acid	NN
cord-021419-nypnib0h	691	66	OSA	OSA	NNP
cord-021419-nypnib0h	691	67	(	(	-LRB-
cord-021419-nypnib0h	691	68	124	124	CD
cord-021419-nypnib0h	691	69	)	)	-RRB-
cord-021419-nypnib0h	692	1	(	(	-LRB-
cord-021419-nypnib0h	692	2	K	K	NNP
cord-021419-nypnib0h	692	3	a	a	DT
cord-021419-nypnib0h	692	4	=	=	SYM
cord-021419-nypnib0h	692	5	1.35610	1.35610	CD
cord-021419-nypnib0h	692	6	5	5	CD
cord-021419-nypnib0h	692	7	versus	versus	IN
cord-021419-nypnib0h	692	8	2.1610	2.1610	CD
cord-021419-nypnib0h	692	9	4	4	CD
cord-021419-nypnib0h	692	10	mol	mol	NN
cord-021419-nypnib0h	692	11	L	L	NNP
cord-021419-nypnib0h	692	12	71	71	CD
cord-021419-nypnib0h	692	13	,	,	,
cord-021419-nypnib0h	692	14	as	as	IN
cord-021419-nypnib0h	692	15	evaluated	evaluate	VBN
cord-021419-nypnib0h	692	16	by	by	IN
cord-021419-nypnib0h	692	17	FT	FT	NNP
cord-021419-nypnib0h	692	18	)	)	-RRB-
cord-021419-nypnib0h	692	19	.	.	.
cord-021419-nypnib0h	693	1	However	however	RB
cord-021419-nypnib0h	693	2	,	,	,
cord-021419-nypnib0h	693	3	the	the	DT
cord-021419-nypnib0h	693	4	presence	presence	NN
cord-021419-nypnib0h	693	5	of	of	IN
cord-021419-nypnib0h	693	6	the	the	DT
cord-021419-nypnib0h	693	7	bulky	bulky	JJ
cord-021419-nypnib0h	693	8	adamantyl	adamantyl	NN
cord-021419-nypnib0h	693	9	substituent	substituent	NN
cord-021419-nypnib0h	693	10	in	in	IN
cord-021419-nypnib0h	693	11	compound	compound	NN
cord-021419-nypnib0h	693	12	121	121	CD
cord-021419-nypnib0h	693	13	results	result	NNS
cord-021419-nypnib0h	693	14	in	in	IN
cord-021419-nypnib0h	693	15	a	a	DT
cord-021419-nypnib0h	693	16	decrease	decrease	NN
cord-021419-nypnib0h	693	17	in	in	IN
cord-021419-nypnib0h	693	18	the	the	DT
cord-021419-nypnib0h	693	19	binding	binding	JJ
cord-021419-nypnib0h	693	20	constant	constant	NN
cord-021419-nypnib0h	693	21	of	of	IN
cord-021419-nypnib0h	693	22	the	the	DT
cord-021419-nypnib0h	693	23	dimer	dimer	NN
cord-021419-nypnib0h	693	24	[	[	-LRB-
cord-021419-nypnib0h	693	25	121	121	CD
cord-021419-nypnib0h	693	26	]	]	-RRB-
cord-021419-nypnib0h	693	27	2	2	CD
cord-021419-nypnib0h	693	28	Mg	Mg	NNP
cord-021419-nypnib0h	693	29	2	2	CD
cord-021419-nypnib0h	693	30	+	+	CC
cord-021419-nypnib0h	693	31	with	with	IN
cord-021419-nypnib0h	693	32	the	the	DT
cord-021419-nypnib0h	693	33	DNA	dna	NN
cord-021419-nypnib0h	693	34	duplex	duplex	NN
cord-021419-nypnib0h	693	35	by	by	IN
cord-021419-nypnib0h	693	36	an	an	DT
cord-021419-nypnib0h	693	37	order	order	NN
cord-021419-nypnib0h	693	38	of	of	IN
cord-021419-nypnib0h	693	39	magnitude	magnitude	NN
cord-021419-nypnib0h	693	40	(	(	-LRB-
cord-021419-nypnib0h	693	41	K	K	NNP
cord-021419-nypnib0h	693	42	a	a	DT
cord-021419-nypnib0h	693	43	=	=	SYM
cord-021419-nypnib0h	693	44	1.32610	1.32610	CD
cord-021419-nypnib0h	693	45	4	4	CD
cord-021419-nypnib0h	693	46	mol	mol	NN
cord-021419-nypnib0h	693	47	L	L	NNP
cord-021419-nypnib0h	693	48	71	71	CD
cord-021419-nypnib0h	693	49	)	)	-RRB-
cord-021419-nypnib0h	693	50	.	.	.
cord-021419-nypnib0h	694	1	81	81	CD
cord-021419-nypnib0h	695	1	The	the	DT
cord-021419-nypnib0h	695	2	elimination	elimination	NN
cord-021419-nypnib0h	695	3	of	of	IN
cord-021419-nypnib0h	695	4	one	one	CD
cord-021419-nypnib0h	695	5	acyl	acyl	NN
cord-021419-nypnib0h	695	6	substituent	substituent	NN
cord-021419-nypnib0h	695	7	also	also	RB
cord-021419-nypnib0h	695	8	leads	lead	VBZ
cord-021419-nypnib0h	695	9	to	to	IN
cord-021419-nypnib0h	695	10	a	a	DT
cord-021419-nypnib0h	695	11	decrease	decrease	NN
cord-021419-nypnib0h	695	12	in	in	IN
cord-021419-nypnib0h	695	13	the	the	DT
cord-021419-nypnib0h	695	14	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	695	15	activity	activity	NN
cord-021419-nypnib0h	695	16	compared	compare	VBN
cord-021419-nypnib0h	695	17	to	to	IN
cord-021419-nypnib0h	695	18	that	that	DT
cord-021419-nypnib0h	695	19	of	of	IN
cord-021419-nypnib0h	695	20	antibiotic	antibiotic	NN
cord-021419-nypnib0h	695	21	110	110	CD
cord-021419-nypnib0h	695	22	due	due	JJ
cord-021419-nypnib0h	695	23	probably	probably	RB
cord-021419-nypnib0h	695	24	to	to	IN
cord-021419-nypnib0h	695	25	a	a	DT
cord-021419-nypnib0h	695	26	decrease	decrease	NN
cord-021419-nypnib0h	695	27	in	in	IN
cord-021419-nypnib0h	695	28	its	-PRON-	PRP$
cord-021419-nypnib0h	695	29	affinity	affinity	NN
cord-021419-nypnib0h	695	30	for	for	IN
cord-021419-nypnib0h	695	31	DNA	dna	NN
cord-021419-nypnib0h	695	32	.	.	.
cord-021419-nypnib0h	696	1	77	77	CD
cord-021419-nypnib0h	697	1	The	the	DT
cord-021419-nypnib0h	697	2	molecular	molecular	JJ
cord-021419-nypnib0h	697	3	docking	docking	NN
cord-021419-nypnib0h	697	4	of	of	IN
cord-021419-nypnib0h	697	5	complex	complex	NN
cord-021419-nypnib0h	697	6	of	of	IN
cord-021419-nypnib0h	697	7	110	110	CD
cord-021419-nypnib0h	697	8	with	with	IN
cord-021419-nypnib0h	697	9	DNA	dna	NN
cord-021419-nypnib0h	697	10	shows	show	NNS
cord-021419-nypnib0h	697	11	that	that	IN
cord-021419-nypnib0h	697	12	the	the	DT
cord-021419-nypnib0h	697	13	antibiotic	antibiotic	NN
cord-021419-nypnib0h	697	14	can	can	MD
cord-021419-nypnib0h	697	15	bind	bind	VB
cord-021419-nypnib0h	697	16	only	only	RB
cord-021419-nypnib0h	697	17	to	to	IN
cord-021419-nypnib0h	697	18	GC	gc	NN
cord-021419-nypnib0h	697	19	-	-	HYPH
cord-021419-nypnib0h	697	20	rich	rich	JJ
cord-021419-nypnib0h	697	21	regions	region	NNS
cord-021419-nypnib0h	697	22	in	in	IN
cord-021419-nypnib0h	697	23	the	the	DT
cord-021419-nypnib0h	697	24	minor	minor	JJ
cord-021419-nypnib0h	697	25	groove	groove	NN
cord-021419-nypnib0h	697	26	of	of	IN
cord-021419-nypnib0h	697	27	the	the	DT
cord-021419-nypnib0h	697	28	DNA	dna	NN
cord-021419-nypnib0h	697	29	duplex	duplex	NN
cord-021419-nypnib0h	697	30	.	.	.
cord-021419-nypnib0h	698	1	82	82	CD
cord-021419-nypnib0h	698	2	Carbohydrate	Carbohydrate	NNP
cord-021419-nypnib0h	698	3	chains	chain	NNS
cord-021419-nypnib0h	698	4	of	of	IN
cord-021419-nypnib0h	698	5	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	698	6	interact	interact	VBP
cord-021419-nypnib0h	698	7	with	with	IN
cord-021419-nypnib0h	698	8	the	the	DT
cord-021419-nypnib0h	698	9	sugar	sugar	NN
cord-021419-nypnib0h	698	10	±	±	NNP
cord-021419-nypnib0h	698	11	phosphate	phosphate	NN
cord-021419-nypnib0h	698	12	backbone	backbone	NN
cord-021419-nypnib0h	698	13	of	of	IN
cord-021419-nypnib0h	698	14	DNA	dna	NN
cord-021419-nypnib0h	698	15	,	,	,
cord-021419-nypnib0h	698	16	and	and	CC
cord-021419-nypnib0h	698	17	the	the	DT
cord-021419-nypnib0h	698	18	aglycone	aglycone	NN
cord-021419-nypnib0h	698	19	interacts	interact	VBZ
cord-021419-nypnib0h	698	20	with	with	IN
cord-021419-nypnib0h	698	21	nucleic	nucleic	JJ
cord-021419-nypnib0h	698	22	acid	acid	NN
cord-021419-nypnib0h	698	23	bases	basis	NNS
cord-021419-nypnib0h	698	24	.	.	.
cord-021419-nypnib0h	699	1	The	the	DT
cord-021419-nypnib0h	699	2	sites	site	NNS
cord-021419-nypnib0h	699	3	of	of	IN
cord-021419-nypnib0h	699	4	110	110	CD
cord-021419-nypnib0h	699	5	responsible	responsible	JJ
cord-021419-nypnib0h	699	6	for	for	IN
cord-021419-nypnib0h	699	7	the	the	DT
cord-021419-nypnib0h	699	8	interaction	interaction	NN
cord-021419-nypnib0h	699	9	with	with	IN
cord-021419-nypnib0h	699	10	DNA	DNA	NNP
cord-021419-nypnib0h	699	11	(	(	-LRB-
cord-021419-nypnib0h	699	12	an	an	DT
cord-021419-nypnib0h	699	13	additional	additional	JJ
cord-021419-nypnib0h	699	14	hydrogen	hydrogen	NN
cord-021419-nypnib0h	699	15	bond	bond	NN
cord-021419-nypnib0h	699	16	with	with	IN
cord-021419-nypnib0h	699	17	the	the	DT
cord-021419-nypnib0h	699	18	NH	NH	NNP
cord-021419-nypnib0h	699	19	2	2	CD
cord-021419-nypnib0h	699	20	group	group	NN
cord-021419-nypnib0h	699	21	of	of	IN
cord-021419-nypnib0h	699	22	the	the	DT
cord-021419-nypnib0h	699	23	G	G	NNP
cord-021419-nypnib0h	699	24	base	base	NN
cord-021419-nypnib0h	699	25	)	)	-RRB-
cord-021419-nypnib0h	699	26	and	and	CC
cord-021419-nypnib0h	699	27	the	the	DT
cord-021419-nypnib0h	699	28	complexation	complexation	NN
cord-021419-nypnib0h	699	29	of	of	IN
cord-021419-nypnib0h	699	30	the	the	DT
cord-021419-nypnib0h	699	31	antibiotic	antibiotic	NN
cord-021419-nypnib0h	699	32	with	with	IN
cord-021419-nypnib0h	699	33	DNA	DNA	NNP
cord-021419-nypnib0h	699	34	were	be	VBD
cord-021419-nypnib0h	699	35	identified	identify	VBN
cord-021419-nypnib0h	699	36	.	.	.
cord-021419-nypnib0h	700	1	The	the	DT
cord-021419-nypnib0h	700	2	structural	structural	JJ
cord-021419-nypnib0h	700	3	fragment	fragment	NN
cord-021419-nypnib0h	700	4	,	,	,
cord-021419-nypnib0h	700	5	which	which	WDT
cord-021419-nypnib0h	700	6	is	be	VBZ
cord-021419-nypnib0h	700	7	not	not	RB
cord-021419-nypnib0h	700	8	directly	directly	RB
cord-021419-nypnib0h	700	9	involved	involve	VBN
cord-021419-nypnib0h	700	10	in	in	IN
cord-021419-nypnib0h	700	11	the	the	DT
cord-021419-nypnib0h	700	12	interaction	interaction	NN
cord-021419-nypnib0h	700	13	with	with	IN
cord-021419-nypnib0h	700	14	DNA	dna	NN
cord-021419-nypnib0h	700	15	but	but	CC
cord-021419-nypnib0h	700	16	models	model	VBZ
cord-021419-nypnib0h	700	17	the	the	DT
cord-021419-nypnib0h	700	18	affinity	affinity	NN
cord-021419-nypnib0h	700	19	of	of	IN
cord-021419-nypnib0h	700	20	the	the	DT
cord-021419-nypnib0h	700	21	antibiotic	antibiotic	NN
cord-021419-nypnib0h	700	22	to	to	IN
cord-021419-nypnib0h	700	23	the	the	DT
cord-021419-nypnib0h	700	24	target	target	NN
cord-021419-nypnib0h	700	25	Ð	Ð	NNP
cord-021419-nypnib0h	700	26	the	the	DT
cord-021419-nypnib0h	700	27	minor	minor	JJ
cord-021419-nypnib0h	700	28	groove	groove	NN
cord-021419-nypnib0h	700	29	of	of	IN
cord-021419-nypnib0h	700	30	the	the	DT
cord-021419-nypnib0h	700	31	DNA	dna	NN
cord-021419-nypnib0h	700	32	duplex	duplex	NN
cord-021419-nypnib0h	700	33	,	,	,
cord-021419-nypnib0h	700	34	was	be	VBD
cord-021419-nypnib0h	700	35	determined	determine	VBN
cord-021419-nypnib0h	700	36	.	.	.
cord-021419-nypnib0h	701	1	Based	base	VBN
cord-021419-nypnib0h	701	2	on	on	IN
cord-021419-nypnib0h	701	3	these	these	DT
cord-021419-nypnib0h	701	4	data	datum	NNS
cord-021419-nypnib0h	701	5	,	,	,
cord-021419-nypnib0h	701	6	a	a	DT
cord-021419-nypnib0h	701	7	schematic	schematic	JJ
cord-021419-nypnib0h	701	8	model	model	NN
cord-021419-nypnib0h	701	9	of	of	IN
cord-021419-nypnib0h	701	10	the	the	DT
cord-021419-nypnib0h	701	11	interaction	interaction	NN
cord-021419-nypnib0h	701	12	between	between	IN
cord-021419-nypnib0h	701	13	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	701	14	A	A	NNP
cord-021419-nypnib0h	701	15	and	and	CC
cord-021419-nypnib0h	701	16	DNA	DNA	NNP
cord-021419-nypnib0h	701	17	was	be	VBD
cord-021419-nypnib0h	701	18	proposed	propose	VBN
cord-021419-nypnib0h	701	19	(	(	-LRB-
cord-021419-nypnib0h	701	20	Scheme	scheme	NN
cord-021419-nypnib0h	701	21	38	38	CD
cord-021419-nypnib0h	701	22	)	)	-RRB-
cord-021419-nypnib0h	701	23	.	.	.
cord-021419-nypnib0h	702	1	73	73	CD
cord-021419-nypnib0h	703	1	Two	two	CD
cord-021419-nypnib0h	703	2	semi	semi	JJ
cord-021419-nypnib0h	703	3	-	-	JJ
cord-021419-nypnib0h	703	4	synthetic	synthetic	JJ
cord-021419-nypnib0h	703	5	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	703	6	derivatives	derivative	NNS
cord-021419-nypnib0h	703	7	(	(	-LRB-
cord-021419-nypnib0h	703	8	121	121	CD
cord-021419-nypnib0h	703	9	and	and	CC
cord-021419-nypnib0h	703	10	127	127	CD
cord-021419-nypnib0h	703	11	)	)	-RRB-
cord-021419-nypnib0h	703	12	with	with	IN
cord-021419-nypnib0h	703	13	the	the	DT
cord-021419-nypnib0h	703	14	modified	modify	VBN
cord-021419-nypnib0h	703	15	aglycone	aglycone	NNP
cord-021419-nypnib0h	703	16	side	side	NN
cord-021419-nypnib0h	703	17	chain	chain	NN
cord-021419-nypnib0h	703	18	were	be	VBD
cord-021419-nypnib0h	703	19	chosen	choose	VBN
cord-021419-nypnib0h	703	20	based	base	VBN
cord-021419-nypnib0h	703	21	on	on	IN
cord-021419-nypnib0h	703	22	the	the	DT
cord-021419-nypnib0h	703	23	evaluation	evaluation	NN
cord-021419-nypnib0h	703	24	of	of	IN
cord-021419-nypnib0h	703	25	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	703	26	activity	activity	NN
cord-021419-nypnib0h	703	27	in	in	IN
cord-021419-nypnib0h	703	28	animal	animal	NN
cord-021419-nypnib0h	703	29	assays	assay	NNS
cord-021419-nypnib0h	703	30	.	.	.
cord-021419-nypnib0h	704	1	Compound	Compound	NNP
cord-021419-nypnib0h	704	2	121	121	CD
cord-021419-nypnib0h	704	3	is	be	VBZ
cord-021419-nypnib0h	704	4	more	more	RBR
cord-021419-nypnib0h	704	5	effective	effective	JJ
cord-021419-nypnib0h	704	6	in	in	IN
cord-021419-nypnib0h	704	7	the	the	DT
cord-021419-nypnib0h	704	8	treatment	treatment	NN
cord-021419-nypnib0h	704	9	of	of	IN
cord-021419-nypnib0h	704	10	P388	P388	NNP
cord-021419-nypnib0h	704	11	murine	murine	JJ
cord-021419-nypnib0h	704	12	leukaemia	leukaemia	NN
cord-021419-nypnib0h	704	13	than	than	IN
cord-021419-nypnib0h	704	14	the	the	DT
cord-021419-nypnib0h	704	15	starting	start	VBG
cord-021419-nypnib0h	704	16	antibiotic	antibiotic	NN
cord-021419-nypnib0h	704	17	110	110	CD
cord-021419-nypnib0h	704	18	due	due	IN
cord-021419-nypnib0h	704	19	to	to	IN
cord-021419-nypnib0h	704	20	a	a	DT
cord-021419-nypnib0h	704	21	decrease	decrease	NN
cord-021419-nypnib0h	704	22	in	in	IN
cord-021419-nypnib0h	704	23	toxicity	toxicity	NN
cord-021419-nypnib0h	704	24	and	and	CC
cord-021419-nypnib0h	704	25	the	the	DT
cord-021419-nypnib0h	704	26	absence	absence	NN
cord-021419-nypnib0h	704	27	of	of	IN
cord-021419-nypnib0h	704	28	the	the	DT
cord-021419-nypnib0h	704	29	cumulative	cumulative	JJ
cord-021419-nypnib0h	704	30	effect	effect	NN
cord-021419-nypnib0h	704	31	.	.	.
cord-021419-nypnib0h	705	1	83	83	CD
cord-021419-nypnib0h	705	2	,	,	,
cord-021419-nypnib0h	705	3	84	84	CD
cord-021419-nypnib0h	705	4	Compound	compound	NN
cord-021419-nypnib0h	705	5	127	127	CD
cord-021419-nypnib0h	705	6	(	(	-LRB-
cord-021419-nypnib0h	705	7	olivamide	olivamide	NN
cord-021419-nypnib0h	705	8	)	)	-RRB-
cord-021419-nypnib0h	705	9	is	be	VBZ
cord-021419-nypnib0h	705	10	also	also	RB
cord-021419-nypnib0h	705	11	more	more	RBR
cord-021419-nypnib0h	705	12	effective	effective	JJ
cord-021419-nypnib0h	705	13	in	in	IN
cord-021419-nypnib0h	705	14	this	this	DT
cord-021419-nypnib0h	705	15	assay	assay	NN
cord-021419-nypnib0h	705	16	compared	compare	VBN
cord-021419-nypnib0h	705	17	to	to	IN
cord-021419-nypnib0h	705	18	the	the	DT
cord-021419-nypnib0h	705	19	starting	start	VBG
cord-021419-nypnib0h	705	20	antibiotic	antibiotic	NN
cord-021419-nypnib0h	705	21	110	110	CD
cord-021419-nypnib0h	705	22	.	.	.
cord-021419-nypnib0h	706	1	85	85	CD
cord-021419-nypnib0h	707	1	Detailed	detailed	JJ
cord-021419-nypnib0h	707	2	preclinical	preclinical	JJ
cord-021419-nypnib0h	707	3	assays	assay	NNS
cord-021419-nypnib0h	707	4	in	in	IN
cord-021419-nypnib0h	707	5	transplanted	transplant	VBN
cord-021419-nypnib0h	707	6	syngeneic	syngeneic	NNS
cord-021419-nypnib0h	707	7	tumours	tumour	NNS
cord-021419-nypnib0h	707	8	confirmed	confirm	VBD
cord-021419-nypnib0h	707	9	the	the	DT
cord-021419-nypnib0h	707	10	efficacy	efficacy	NN
cord-021419-nypnib0h	707	11	of	of	IN
cord-021419-nypnib0h	707	12	the	the	DT
cord-021419-nypnib0h	707	13	agent	agent	NN
cord-021419-nypnib0h	707	14	based	base	VBN
cord-021419-nypnib0h	707	15	on	on	IN
cord-021419-nypnib0h	707	16	compound	compound	NN
cord-021419-nypnib0h	707	17	127	127	CD
cord-021419-nypnib0h	707	18	for	for	IN
cord-021419-nypnib0h	707	19	further	further	JJ
cord-021419-nypnib0h	707	20	clinical	clinical	JJ
cord-021419-nypnib0h	707	21	trials	trial	NNS
cord-021419-nypnib0h	707	22	.	.	.
cord-021419-nypnib0h	708	1	85	85	CD
cord-021419-nypnib0h	708	2	±	±	CD
cord-021419-nypnib0h	708	3	88	88	CD
cord-021419-nypnib0h	709	1	These	these	DT
cord-021419-nypnib0h	709	2	studies	study	NNS
cord-021419-nypnib0h	709	3	enabled	enable	VBD
cord-021419-nypnib0h	709	4	the	the	DT
cord-021419-nypnib0h	709	5	development	development	NN
cord-021419-nypnib0h	709	6	of	of	IN
cord-021419-nypnib0h	709	7	methods	method	NNS
cord-021419-nypnib0h	709	8	for	for	IN
cord-021419-nypnib0h	709	9	selective	selective	JJ
cord-021419-nypnib0h	709	10	chemical	chemical	NN
cord-021419-nypnib0h	709	11	modification	modification	NN
cord-021419-nypnib0h	709	12	of	of	IN
cord-021419-nypnib0h	709	13	the	the	DT
cord-021419-nypnib0h	709	14	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	709	15	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	709	16	A	A	NNP
cord-021419-nypnib0h	709	17	,	,	,
cord-021419-nypnib0h	709	18	resulting	result	VBG
cord-021419-nypnib0h	709	19	in	in	IN
cord-021419-nypnib0h	709	20	the	the	DT
cord-021419-nypnib0h	709	21	synthesis	synthesis	NN
cord-021419-nypnib0h	709	22	of	of	IN
cord-021419-nypnib0h	709	23	a	a	DT
cord-021419-nypnib0h	709	24	series	series	NN
cord-021419-nypnib0h	709	25	of	of	IN
cord-021419-nypnib0h	709	26	semi	semi	JJ
cord-021419-nypnib0h	709	27	-	-	JJ
cord-021419-nypnib0h	709	28	synthetic	synthetic	JJ
cord-021419-nypnib0h	709	29	derivatives	derivative	NNS
cord-021419-nypnib0h	709	30	of	of	IN
cord-021419-nypnib0h	709	31	this	this	DT
cord-021419-nypnib0h	709	32	antibiotic	antibiotic	NN
cord-021419-nypnib0h	709	33	;	;	:
cord-021419-nypnib0h	709	34	besides	besides	RB
cord-021419-nypnib0h	709	35	,	,	,
cord-021419-nypnib0h	709	36	structure	structure	NN
cord-021419-nypnib0h	709	37	±	±	CD
cord-021419-nypnib0h	709	38	activity	activity	NN
cord-021419-nypnib0h	709	39	relationship	relationship	NN
cord-021419-nypnib0h	709	40	analysis	analysis	NN
cord-021419-nypnib0h	709	41	was	be	VBD
cord-021419-nypnib0h	709	42	performed	perform	VBN
cord-021419-nypnib0h	709	43	.	.	.
cord-021419-nypnib0h	710	1	70	70	CD
cord-021419-nypnib0h	710	2	,	,	,
cord-021419-nypnib0h	710	3	73	73	CD
cord-021419-nypnib0h	710	4	Many	many	JJ
cord-021419-nypnib0h	710	5	of	of	IN
cord-021419-nypnib0h	710	6	these	these	DT
cord-021419-nypnib0h	710	7	compounds	compound	NNS
cord-021419-nypnib0h	710	8	exhibited	exhibit	VBD
cord-021419-nypnib0h	710	9	high	high	JJ
cord-021419-nypnib0h	710	10	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	710	11	activity	activity	NN
cord-021419-nypnib0h	710	12	in	in	IN
cord-021419-nypnib0h	710	13	different	different	JJ
cord-021419-nypnib0h	710	14	tumour	tumour	NN
cord-021419-nypnib0h	710	15	cell	cell	NN
cord-021419-nypnib0h	710	16	lines	line	NNS
cord-021419-nypnib0h	710	17	.	.	.
cord-021419-nypnib0h	711	1	Some	some	DT
cord-021419-nypnib0h	711	2	aspects	aspect	NNS
cord-021419-nypnib0h	711	3	of	of	IN
cord-021419-nypnib0h	711	4	the	the	DT
cord-021419-nypnib0h	711	5	mechanism	mechanism	NN
cord-021419-nypnib0h	711	6	of	of	IN
cord-021419-nypnib0h	711	7	action	action	NN
cord-021419-nypnib0h	711	8	of	of	IN
cord-021419-nypnib0h	711	9	olivomycin	olivomycin	NNP
cord-021419-nypnib0h	711	10	A	A	NNP
cord-021419-nypnib0h	711	11	and	and	CC
cord-021419-nypnib0h	711	12	its	-PRON-	PRP$
cord-021419-nypnib0h	711	13	natural	natural	JJ
cord-021419-nypnib0h	711	14	and	and	CC
cord-021419-nypnib0h	711	15	semi	semi	JJ
cord-021419-nypnib0h	711	16	-	-	JJ
cord-021419-nypnib0h	711	17	synthetic	synthetic	JJ
cord-021419-nypnib0h	711	18	analogues	analogue	NNS
cord-021419-nypnib0h	711	19	were	be	VBD
cord-021419-nypnib0h	711	20	considered	consider	VBN
cord-021419-nypnib0h	711	21	.	.	.
cord-021419-nypnib0h	712	1	74	74	CD
cord-021419-nypnib0h	712	2	,	,	,
cord-021419-nypnib0h	712	3	75	75	CD
cord-021419-nypnib0h	712	4	,	,	,
cord-021419-nypnib0h	712	5	77	77	CD
cord-021419-nypnib0h	712	6	,	,	,
cord-021419-nypnib0h	712	7	79	79	CD
cord-021419-nypnib0h	712	8	±	±	CD
cord-021419-nypnib0h	712	9	82	82	CD
cord-021419-nypnib0h	713	1	It	-PRON-	PRP
cord-021419-nypnib0h	713	2	was	be	VBD
cord-021419-nypnib0h	713	3	concluded	conclude	VBN
cord-021419-nypnib0h	713	4	that	that	IN
cord-021419-nypnib0h	713	5	high	high	JJ
cord-021419-nypnib0h	713	6	antitumour	antitumour	JJ
cord-021419-nypnib0h	713	7	activity	activity	NN
cord-021419-nypnib0h	713	8	of	of	IN
cord-021419-nypnib0h	713	9	these	these	DT
cord-021419-nypnib0h	713	10	compounds	compound	NNS
cord-021419-nypnib0h	713	11	is	be	VBZ
cord-021419-nypnib0h	713	12	related	relate	VBN
cord-021419-nypnib0h	713	13	to	to	IN
cord-021419-nypnib0h	713	14	their	-PRON-	PRP$
cord-021419-nypnib0h	713	15	high	high	JJ
cord-021419-nypnib0h	713	16	affinity	affinity	NN
cord-021419-nypnib0h	713	17	to	to	IN
cord-021419-nypnib0h	713	18	the	the	DT
cord-021419-nypnib0h	713	19	DNA	dna	NN
cord-021419-nypnib0h	713	20	duplex	duplex	NN
cord-021419-nypnib0h	713	21	.	.	.
cord-021419-nypnib0h	714	1	Based	base	VBN
cord-021419-nypnib0h	714	2	on	on	IN
cord-021419-nypnib0h	714	3	the	the	DT
cord-021419-nypnib0h	714	4	results	result	NNS
cord-021419-nypnib0h	714	5	of	of	IN
cord-021419-nypnib0h	714	6	in	in	FW
cord-021419-nypnib0h	714	7	vitro	vitro	FW
cord-021419-nypnib0h	714	8	assays	assay	NNS
cord-021419-nypnib0h	714	9	,	,	,
cord-021419-nypnib0h	714	10	compounds	compound	NNS
cord-021419-nypnib0h	714	11	were	be	VBD
cord-021419-nypnib0h	714	12	chosen	choose	VBN
cord-021419-nypnib0h	714	13	for	for	IN
cord-021419-nypnib0h	714	14	the	the	DT
cord-021419-nypnib0h	714	15	evaluation	evaluation	NN
cord-021419-nypnib0h	714	16	of	of	IN
cord-021419-nypnib0h	714	17	antitumour	antitumour	JJ
cord-021419-nypnib0h	714	18	activity	activity	NN
cord-021419-nypnib0h	714	19	in	in	IN
cord-021419-nypnib0h	714	20	in	in	IN
cord-021419-nypnib0h	714	21	vivo	vivo	NN
cord-021419-nypnib0h	714	22	assays	assay	NNS
cord-021419-nypnib0h	714	23	.	.	.
cord-021419-nypnib0h	715	1	After	after	IN
cord-021419-nypnib0h	715	2	the	the	DT
cord-021419-nypnib0h	715	3	preclinical	preclinical	JJ
cord-021419-nypnib0h	715	4	evaluation	evaluation	NN
cord-021419-nypnib0h	715	5	of	of	IN
cord-021419-nypnib0h	715	6	antitumour	antitumour	JJ
cord-021419-nypnib0h	715	7	activity	activity	NN
cord-021419-nypnib0h	715	8	and	and	CC
cord-021419-nypnib0h	715	9	toxicity	toxicity	NN
cord-021419-nypnib0h	715	10	in	in	IN
cord-021419-nypnib0h	715	11	laboratory	laboratory	NN
cord-021419-nypnib0h	715	12	animals	animal	NNS
cord-021419-nypnib0h	715	13	,	,	,
cord-021419-nypnib0h	715	14	semi	semi	JJ
cord-021419-nypnib0h	715	15	-	-	JJ
cord-021419-nypnib0h	715	16	synthetic	synthetic	JJ
cord-021419-nypnib0h	715	17	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	715	18	analogue	analogue	NN
cord-021419-nypnib0h	715	19	127	127	CD
cord-021419-nypnib0h	715	20	Ð	ð	NN
cord-021419-nypnib0h	715	21	olivamide	olivamide	NN
cord-021419-nypnib0h	715	22	Ð	ð	NN
cord-021419-nypnib0h	715	23	was	be	VBD
cord-021419-nypnib0h	715	24	recommended	recommend	VBN
cord-021419-nypnib0h	715	25	for	for	IN
cord-021419-nypnib0h	715	26	further	further	JJ
cord-021419-nypnib0h	715	27	clinical	clinical	JJ
cord-021419-nypnib0h	715	28	trials	trial	NNS
cord-021419-nypnib0h	715	29	.	.	.
cord-021419-nypnib0h	716	1	85	85	CD
cord-021419-nypnib0h	716	2	±	±	CD
cord-021419-nypnib0h	716	3	89	89	CD
cord-021419-nypnib0h	716	4	Anthracycline	Anthracycline	NNP
cord-021419-nypnib0h	716	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	716	6	are	be	VBP
cord-021419-nypnib0h	716	7	important	important	JJ
cord-021419-nypnib0h	716	8	chemotherapeutic	chemotherapeutic	JJ
cord-021419-nypnib0h	716	9	agents	agent	NNS
cord-021419-nypnib0h	716	10	commonly	commonly	RB
cord-021419-nypnib0h	716	11	used	use	VBN
cord-021419-nypnib0h	716	12	in	in	IN
cord-021419-nypnib0h	716	13	the	the	DT
cord-021419-nypnib0h	716	14	treatment	treatment	NN
cord-021419-nypnib0h	716	15	of	of	IN
cord-021419-nypnib0h	716	16	malignant	malignant	JJ
cord-021419-nypnib0h	716	17	tumours	tumour	NNS
cord-021419-nypnib0h	716	18	.	.	.
cord-021419-nypnib0h	717	1	Daunorubicin	Daunorubicin	NNS
cord-021419-nypnib0h	717	2	(	(	-LRB-
cord-021419-nypnib0h	717	3	137a	137a	NNP
cord-021419-nypnib0h	717	4	)	)	-RRB-
cord-021419-nypnib0h	717	5	,	,	,
cord-021419-nypnib0h	717	6	which	which	WDT
cord-021419-nypnib0h	717	7	was	be	VBD
cord-021419-nypnib0h	717	8	independently	independently	RB
cord-021419-nypnib0h	717	9	discovered	discover	VBN
cord-021419-nypnib0h	717	10	under	under	IN
cord-021419-nypnib0h	717	11	the	the	DT
cord-021419-nypnib0h	717	12	name	name	NN
cord-021419-nypnib0h	717	13	of	of	IN
cord-021419-nypnib0h	717	14	rubomycin	rubomycin	NNS
cord-021419-nypnib0h	717	15	in	in	IN
cord-021419-nypnib0h	717	16	the	the	DT
cord-021419-nypnib0h	717	17	Gause	Gause	NNP
cord-021419-nypnib0h	717	18	Institute	Institute	NNP
cord-021419-nypnib0h	717	19	of	of	IN
cord-021419-nypnib0h	717	20	New	New	NNP
cord-021419-nypnib0h	717	21	Antibiotics	Antibiotics	NNP
cord-021419-nypnib0h	717	22	(	(	-LRB-
cord-021419-nypnib0h	717	23	GINA	GINA	NNP
cord-021419-nypnib0h	717	24	)	)	-RRB-
cord-021419-nypnib0h	717	25	,	,	,
cord-021419-nypnib0h	717	26	6	6	CD
cord-021419-nypnib0h	717	27	is	be	VBZ
cord-021419-nypnib0h	717	28	applied	apply	VBN
cord-021419-nypnib0h	717	29	mainly	mainly	RB
cord-021419-nypnib0h	717	30	for	for	IN
cord-021419-nypnib0h	717	31	the	the	DT
cord-021419-nypnib0h	717	32	treatment	treatment	NN
cord-021419-nypnib0h	717	33	of	of	IN
cord-021419-nypnib0h	717	34	leukaemia	leukaemia	NN
cord-021419-nypnib0h	717	35	in	in	IN
cord-021419-nypnib0h	717	36	children	child	NNS
cord-021419-nypnib0h	717	37	and	and	CC
cord-021419-nypnib0h	717	38	adults	adult	NNS
cord-021419-nypnib0h	717	39	.	.	.
cord-021419-nypnib0h	718	1	Doxorubicin	Doxorubicin	NNP
cord-021419-nypnib0h	718	2	(	(	-LRB-
cord-021419-nypnib0h	718	3	14-hydroxydaunorubicin	14-hydroxydaunorubicin	CD
cord-021419-nypnib0h	718	4	,	,	,
cord-021419-nypnib0h	718	5	DOX	DOX	NNP
cord-021419-nypnib0h	718	6	)	)	-RRB-
cord-021419-nypnib0h	718	7	(	(	-LRB-
cord-021419-nypnib0h	718	8	138a	138a	CD
cord-021419-nypnib0h	718	9	)	)	-RRB-
cord-021419-nypnib0h	718	10	is	be	VBZ
cord-021419-nypnib0h	718	11	used	use	VBN
cord-021419-nypnib0h	718	12	in	in	IN
cord-021419-nypnib0h	718	13	combination	combination	NN
cord-021419-nypnib0h	718	14	chemotherapy	chemotherapy	NN
cord-021419-nypnib0h	718	15	of	of	IN
cord-021419-nypnib0h	718	16	breast	breast	NN
cord-021419-nypnib0h	718	17	cancer	cancer	NN
cord-021419-nypnib0h	718	18	,	,	,
cord-021419-nypnib0h	718	19	smallcell	smallcell	NNP
cord-021419-nypnib0h	718	20	lung	lung	NNP
cord-021419-nypnib0h	718	21	cancer	cancer	NN
cord-021419-nypnib0h	718	22	,	,	,
cord-021419-nypnib0h	718	23	sarcoma	sarcoma	NN
cord-021419-nypnib0h	718	24	,	,	,
cord-021419-nypnib0h	718	25	tumours	tumour	NNS
cord-021419-nypnib0h	718	26	in	in	IN
cord-021419-nypnib0h	718	27	children	child	NNS
cord-021419-nypnib0h	718	28	and	and	CC
cord-021419-nypnib0h	718	29	haemoblastosis	haemoblastosis	NN
cord-021419-nypnib0h	718	30	.	.	.
cord-021419-nypnib0h	719	1	An	an	DT
cord-021419-nypnib0h	719	2	original	original	JJ
cord-021419-nypnib0h	719	3	method	method	NN
cord-021419-nypnib0h	719	4	for	for	IN
cord-021419-nypnib0h	719	5	the	the	DT
cord-021419-nypnib0h	719	6	one	one	CD
cord-021419-nypnib0h	719	7	-	-	HYPH
cord-021419-nypnib0h	719	8	pot	pot	NN
cord-021419-nypnib0h	719	9	preparation	preparation	NN
cord-021419-nypnib0h	719	10	of	of	IN
cord-021419-nypnib0h	719	11	semi	semi	JJ
cord-021419-nypnib0h	719	12	-	-	JJ
cord-021419-nypnib0h	719	13	synthetic	synthetic	JJ
cord-021419-nypnib0h	719	14	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	719	15	from	from	IN
cord-021419-nypnib0h	719	16	rubomycin	rubomycin	NNS
cord-021419-nypnib0h	719	17	was	be	VBD
cord-021419-nypnib0h	719	18	developed	develop	VBN
cord-021419-nypnib0h	719	19	in	in	IN
cord-021419-nypnib0h	719	20	the	the	DT
cord-021419-nypnib0h	719	21	GINA	GINA	NNP
cord-021419-nypnib0h	719	22	.	.	.
cord-021419-nypnib0h	720	1	6	6	CD
cord-021419-nypnib0h	720	2	Carminomycin	Carminomycin	NNP
cord-021419-nypnib0h	720	3	(	(	-LRB-
cord-021419-nypnib0h	720	4	139a	139a	NNP
cord-021419-nypnib0h	720	5	)	)	-RRB-
cord-021419-nypnib0h	720	6	,	,	,
cord-021419-nypnib0h	720	7	which	which	WDT
cord-021419-nypnib0h	720	8	was	be	VBD
cord-021419-nypnib0h	720	9	also	also	RB
cord-021419-nypnib0h	720	10	discovered	discover	VBN
cord-021419-nypnib0h	720	11	in	in	IN
cord-021419-nypnib0h	720	12	the	the	DT
cord-021419-nypnib0h	720	13	GINA	GINA	NNP
cord-021419-nypnib0h	720	14	,	,	,
cord-021419-nypnib0h	720	15	has	have	VBZ
cord-021419-nypnib0h	720	16	lower	low	JJR
cord-021419-nypnib0h	720	17	cardiotoxicity	cardiotoxicity	NN
cord-021419-nypnib0h	720	18	than	than	IN
cord-021419-nypnib0h	720	19	other	other	JJ
cord-021419-nypnib0h	720	20	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	720	21	and	and	CC
cord-021419-nypnib0h	720	22	can	can	MD
cord-021419-nypnib0h	720	23	inhibit	inhibit	VB
cord-021419-nypnib0h	720	24	the	the	DT
cord-021419-nypnib0h	720	25	growth	growth	NN
cord-021419-nypnib0h	720	26	of	of	IN
cord-021419-nypnib0h	720	27	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	720	28	-	-	HYPH
cord-021419-nypnib0h	720	29	resistant	resistant	JJ
cord-021419-nypnib0h	720	30	tumours	tumour	NNS
cord-021419-nypnib0h	720	31	(	(	-LRB-
cord-021419-nypnib0h	720	32	138a	138a	CD
cord-021419-nypnib0h	720	33	)	)	-RRB-
cord-021419-nypnib0h	720	34	.	.	.
cord-021419-nypnib0h	721	1	90	90	CD
cord-021419-nypnib0h	722	1	The	the	DT
cord-021419-nypnib0h	722	2	structures	structure	NNS
cord-021419-nypnib0h	722	3	of	of	IN
cord-021419-nypnib0h	722	4	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	722	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	722	6	137a	137a	CD
cord-021419-nypnib0h	722	7	,	,	,
cord-021419-nypnib0h	722	8	138a	138a	CD
cord-021419-nypnib0h	722	9	and	and	CC
cord-021419-nypnib0h	722	10	139a	139a	NNPS
cord-021419-nypnib0h	722	11	are	be	VBP
cord-021419-nypnib0h	722	12	shown	show	VBN
cord-021419-nypnib0h	722	13	in	in	IN
cord-021419-nypnib0h	722	14	Fig	Fig	NNP
cord-021419-nypnib0h	722	15	.	.	.
cord-021419-nypnib0h	723	1	8	8	CD
cord-021419-nypnib0h	723	2	.	.	.
cord-021419-nypnib0h	724	1	The	the	DT
cord-021419-nypnib0h	724	2	mechanism	mechanism	NN
cord-021419-nypnib0h	724	3	of	of	IN
cord-021419-nypnib0h	724	4	cytotoxic	cytotoxic	JJ
cord-021419-nypnib0h	724	5	activity	activity	NN
cord-021419-nypnib0h	724	6	of	of	IN
cord-021419-nypnib0h	724	7	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	724	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	724	9	is	be	VBZ
cord-021419-nypnib0h	724	10	related	relate	VBN
cord-021419-nypnib0h	724	11	mainly	mainly	RB
cord-021419-nypnib0h	724	12	to	to	IN
cord-021419-nypnib0h	724	13	the	the	DT
cord-021419-nypnib0h	724	14	inhibition	inhibition	NN
cord-021419-nypnib0h	724	15	of	of	IN
cord-021419-nypnib0h	724	16	nucleic	nucleic	JJ
cord-021419-nypnib0h	724	17	acid	acid	NN
cord-021419-nypnib0h	724	18	synthesis	synthesis	NN
cord-021419-nypnib0h	724	19	via	via	IN
cord-021419-nypnib0h	724	20	intercalation	intercalation	NN
cord-021419-nypnib0h	724	21	between	between	IN
cord-021419-nypnib0h	724	22	nitrogeneous	nitrogeneous	JJ
cord-021419-nypnib0h	724	23	base	base	NN
cord-021419-nypnib0h	724	24	pairs	pair	NNS
cord-021419-nypnib0h	724	25	,	,	,
cord-021419-nypnib0h	724	26	DNA	dna	NN
cord-021419-nypnib0h	724	27	damage	damage	NN
cord-021419-nypnib0h	724	28	and	and	CC
cord-021419-nypnib0h	724	29	inhibition	inhibition	NN
cord-021419-nypnib0h	724	30	of	of	IN
cord-021419-nypnib0h	724	31	DNA	dna	NN
cord-021419-nypnib0h	724	32	topoisomerases	topoisomerase	NNS
cord-021419-nypnib0h	724	33	.	.	.
cord-021419-nypnib0h	725	1	An	an	DT
cord-021419-nypnib0h	725	2	adverse	adverse	JJ
cord-021419-nypnib0h	725	3	effect	effect	NN
cord-021419-nypnib0h	725	4	of	of	IN
cord-021419-nypnib0h	725	5	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	725	6	is	be	VBZ
cord-021419-nypnib0h	725	7	the	the	DT
cord-021419-nypnib0h	725	8	potentially	potentially	RB
cord-021419-nypnib0h	725	9	irreversible	irreversible	JJ
cord-021419-nypnib0h	725	10	and	and	CC
cord-021419-nypnib0h	725	11	cumulative	cumulative	JJ
cord-021419-nypnib0h	725	12	dose	dose	NN
cord-021419-nypnib0h	725	13	-	-	HYPH
cord-021419-nypnib0h	725	14	related	relate	VBN
cord-021419-nypnib0h	725	15	cardiotoxicity	cardiotoxicity	NN
cord-021419-nypnib0h	725	16	,	,	,
cord-021419-nypnib0h	725	17	apparently	apparently	RB
cord-021419-nypnib0h	725	18	associated	associate	VBN
cord-021419-nypnib0h	725	19	with	with	IN
cord-021419-nypnib0h	725	20	the	the	DT
cord-021419-nypnib0h	725	21	free	free	JJ
cord-021419-nypnib0h	725	22	-	-	HYPH
cord-021419-nypnib0h	725	23	radical	radical	JJ
cord-021419-nypnib0h	725	24	damage	damage	NN
cord-021419-nypnib0h	725	25	of	of	IN
cord-021419-nypnib0h	725	26	myocardial	myocardial	JJ
cord-021419-nypnib0h	725	27	cell	cell	NN
cord-021419-nypnib0h	725	28	membranes	membrane	NNS
cord-021419-nypnib0h	725	29	.	.	.
cord-021419-nypnib0h	726	1	The	the	DT
cord-021419-nypnib0h	726	2	chemical	chemical	JJ
cord-021419-nypnib0h	726	3	modification	modification	NN
cord-021419-nypnib0h	726	4	of	of	IN
cord-021419-nypnib0h	726	5	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	726	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	726	7	was	be	VBD
cord-021419-nypnib0h	726	8	extensively	extensively	RB
cord-021419-nypnib0h	726	9	studied	study	VBN
cord-021419-nypnib0h	726	10	in	in	IN
cord-021419-nypnib0h	726	11	the	the	DT
cord-021419-nypnib0h	726	12	GINA	GINA	NNP
cord-021419-nypnib0h	726	13	for	for	IN
cord-021419-nypnib0h	726	14	a	a	DT
cord-021419-nypnib0h	726	15	long	long	JJ
cord-021419-nypnib0h	726	16	period	period	NN
cord-021419-nypnib0h	726	17	of	of	IN
cord-021419-nypnib0h	726	18	time	time	NN
cord-021419-nypnib0h	726	19	.	.	.
cord-021419-nypnib0h	727	1	In	in	IN
cord-021419-nypnib0h	727	2	recent	recent	JJ
cord-021419-nypnib0h	727	3	years	year	NNS
cord-021419-nypnib0h	727	4	,	,	,
cord-021419-nypnib0h	727	5	efforts	effort	NNS
cord-021419-nypnib0h	727	6	were	be	VBD
cord-021419-nypnib0h	727	7	focused	focus	VBN
cord-021419-nypnib0h	727	8	on	on	IN
cord-021419-nypnib0h	727	9	the	the	DT
cord-021419-nypnib0h	727	10	synthesis	synthesis	NN
cord-021419-nypnib0h	727	11	of	of	IN
cord-021419-nypnib0h	727	12	new	new	JJ
cord-021419-nypnib0h	727	13	semi	semi	JJ
cord-021419-nypnib0h	727	14	-	-	JJ
cord-021419-nypnib0h	727	15	synthetic	synthetic	JJ
cord-021419-nypnib0h	727	16	analogues	analogue	NNS
cord-021419-nypnib0h	727	17	of	of	IN
cord-021419-nypnib0h	727	18	drugs	drug	NNS
cord-021419-nypnib0h	727	19	with	with	IN
cord-021419-nypnib0h	727	20	improved	improved	JJ
cord-021419-nypnib0h	727	21	anticancer	anticancer	JJ
cord-021419-nypnib0h	727	22	properties	property	NNS
cord-021419-nypnib0h	727	23	.	.	.
cord-021419-nypnib0h	728	1	91	91	CD
cord-021419-nypnib0h	728	2	 	 	_SP
cord-021419-nypnib0h	729	1	Daunorubicim	Daunorubicim	NNP
cord-021419-nypnib0h	729	2	(	(	-LRB-
cord-021419-nypnib0h	729	3	137a	137a	NNP
cord-021419-nypnib0h	729	4	)	)	-RRB-
cord-021419-nypnib0h	729	5	and	and	CC
cord-021419-nypnib0h	729	6	carminomycin	carminomycin	NNS
cord-021419-nypnib0h	729	7	(	(	-LRB-
cord-021419-nypnib0h	729	8	139a	139a	NNS
cord-021419-nypnib0h	729	9	)	)	-RRB-
cord-021419-nypnib0h	729	10	were	be	VBD
cord-021419-nypnib0h	729	11	modified	modify	VBN
cord-021419-nypnib0h	729	12	at	at	IN
cord-021419-nypnib0h	729	13	the	the	DT
cord-021419-nypnib0h	729	14	C(14	C(14	NNP
cord-021419-nypnib0h	729	15	)	)	-RRB-
cord-021419-nypnib0h	729	16	atom	atom	NN
cord-021419-nypnib0h	729	17	(	(	-LRB-
cord-021419-nypnib0h	729	18	b	b	NN
cord-021419-nypnib0h	729	19	)	)	-RRB-
cord-021419-nypnib0h	729	20	,	,	,
cord-021419-nypnib0h	729	21	the	the	DT
cord-021419-nypnib0h	729	22	C(13	C(13	NNP
cord-021419-nypnib0h	729	23	)	)	-RRB-
cord-021419-nypnib0h	729	24	=	=	NFP
cord-021419-nypnib0h	730	1	O	o	UH
cord-021419-nypnib0h	730	2	bond	bond	NN
cord-021419-nypnib0h	730	3	(	(	-LRB-
cord-021419-nypnib0h	730	4	c	c	NN
cord-021419-nypnib0h	730	5	)	)	-RRB-
cord-021419-nypnib0h	730	6	and	and	CC
cord-021419-nypnib0h	730	7	the	the	DT
cord-021419-nypnib0h	730	8	daunosamine	daunosamine	NN
cord-021419-nypnib0h	730	9	3	3	CD
cord-021419-nypnib0h	730	10	H	H	NNP
cord-021419-nypnib0h	730	11	-amino	-amino	HYPH
cord-021419-nypnib0h	730	12	group	group	NN
cord-021419-nypnib0h	730	13	(	(	-LRB-
cord-021419-nypnib0h	730	14	d	d	NNP
cord-021419-nypnib0h	730	15	,	,	,
cord-021419-nypnib0h	730	16	e	e	LS
cord-021419-nypnib0h	730	17	)	)	-RRB-
cord-021419-nypnib0h	731	1	(	(	-LRB-
cord-021419-nypnib0h	731	2	see	see	VB
cord-021419-nypnib0h	731	3	Fig	Fig	NNP
cord-021419-nypnib0h	731	4	.	.	.
cord-021419-nypnib0h	731	5	8	8	CD
cord-021419-nypnib0h	731	6	)	)	-RRB-
cord-021419-nypnib0h	731	7	.	.	.
cord-021419-nypnib0h	732	1	3	3	CD
cord-021419-nypnib0h	732	2	H	h	NN
cord-021419-nypnib0h	732	3	-N	-n	NN
cord-021419-nypnib0h	732	4	-	-	:
cord-021419-nypnib0h	732	5	Alkyl	alkyl	NN
cord-021419-nypnib0h	732	6	or	or	CC
cord-021419-nypnib0h	732	7	3	3	CD
cord-021419-nypnib0h	732	8	H	h	NN
cord-021419-nypnib0h	733	1	-N	-N	:
cord-021419-nypnib0h	733	2	-	-	HYPH
cord-021419-nypnib0h	733	3	aminoacyl	aminoacyl	VBN
cord-021419-nypnib0h	733	4	derivatives	derivative	NNS
cord-021419-nypnib0h	733	5	exhibit	exhibit	VBP
cord-021419-nypnib0h	733	6	high	high	JJ
cord-021419-nypnib0h	733	7	antitumour	antitumour	NN
cord-021419-nypnib0h	733	8	activity	activity	NN
cord-021419-nypnib0h	733	9	,	,	,
cord-021419-nypnib0h	733	10	because	because	IN
cord-021419-nypnib0h	733	11	they	-PRON-	PRP
cord-021419-nypnib0h	733	12	retain	retain	VBP
cord-021419-nypnib0h	733	13	the	the	DT
cord-021419-nypnib0h	733	14	amine	amine	NN
cord-021419-nypnib0h	733	15	function	function	NN
cord-021419-nypnib0h	733	16	at	at	IN
cord-021419-nypnib0h	733	17	the	the	DT
cord-021419-nypnib0h	733	18	daunosamine	daunosamine	NNP
cord-021419-nypnib0h	733	19	moiety	moiety	NNP
cord-021419-nypnib0h	733	20	.	.	.
cord-021419-nypnib0h	734	1	90	90	CD
cord-021419-nypnib0h	735	1	This	this	DT
cord-021419-nypnib0h	735	2	function	function	NN
cord-021419-nypnib0h	735	3	is	be	VBZ
cord-021419-nypnib0h	735	4	required	require	VBN
cord-021419-nypnib0h	735	5	for	for	IN
cord-021419-nypnib0h	735	6	the	the	DT
cord-021419-nypnib0h	735	7	primary	primary	JJ
cord-021419-nypnib0h	735	8	interaction	interaction	NN
cord-021419-nypnib0h	735	9	of	of	IN
cord-021419-nypnib0h	735	10	the	the	DT
cord-021419-nypnib0h	735	11	antibiotic	antibiotic	NN
cord-021419-nypnib0h	735	12	with	with	IN
cord-021419-nypnib0h	735	13	the	the	DT
cord-021419-nypnib0h	735	14	sugar	sugar	NN
cord-021419-nypnib0h	735	15	±	±	NNP
cord-021419-nypnib0h	735	16	phosphate	phosphate	NN
cord-021419-nypnib0h	735	17	backbone	backbone	NN
cord-021419-nypnib0h	735	18	of	of	IN
cord-021419-nypnib0h	735	19	DNA	DNA	NNP
cord-021419-nypnib0h	735	20	.	.	.
cord-021419-nypnib0h	736	1	However	however	RB
cord-021419-nypnib0h	736	2	,	,	,
cord-021419-nypnib0h	736	3	the	the	DT
cord-021419-nypnib0h	736	4	drawback	drawback	NN
cord-021419-nypnib0h	736	5	of	of	IN
cord-021419-nypnib0h	736	6	reductive	reductive	JJ
cord-021419-nypnib0h	736	7	alkylation	alkylation	NN
cord-021419-nypnib0h	736	8	of	of	IN
cord-021419-nypnib0h	736	9	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	736	10	137a	137a	NNPS
cord-021419-nypnib0h	736	11	and	and	CC
cord-021419-nypnib0h	736	12	139a	139a	NNPS
cord-021419-nypnib0h	736	13	with	with	IN
cord-021419-nypnib0h	736	14	aldehydes	aldehyde	NNS
cord-021419-nypnib0h	736	15	in	in	IN
cord-021419-nypnib0h	736	16	the	the	DT
cord-021419-nypnib0h	736	17	presence	presence	NN
cord-021419-nypnib0h	736	18	of	of	IN
cord-021419-nypnib0h	736	19	NaBH	NaBH	NNP
cord-021419-nypnib0h	736	20	3	3	CD
cord-021419-nypnib0h	736	21	CN	CN	NNP
cord-021419-nypnib0h	736	22	is	be	VBZ
cord-021419-nypnib0h	736	23	that	that	IN
cord-021419-nypnib0h	736	24	it	-PRON-	PRP
cord-021419-nypnib0h	736	25	is	be	VBZ
cord-021419-nypnib0h	736	26	accompanied	accompany	VBN
cord-021419-nypnib0h	736	27	by	by	IN
cord-021419-nypnib0h	736	28	the	the	DT
cord-021419-nypnib0h	736	29	reduction	reduction	NN
cord-021419-nypnib0h	736	30	of	of	IN
cord-021419-nypnib0h	736	31	the	the	DT
cord-021419-nypnib0h	736	32	C(13	C(13	NNP
cord-021419-nypnib0h	736	33	)	)	-RRB-
cord-021419-nypnib0h	736	34	=	=	NFP
cord-021419-nypnib0h	737	1	O	o	UH
cord-021419-nypnib0h	737	2	group	group	NN
cord-021419-nypnib0h	737	3	as	as	IN
cord-021419-nypnib0h	737	4	the	the	DT
cord-021419-nypnib0h	737	5	side	side	NN
cord-021419-nypnib0h	737	6	reaction	reaction	NN
cord-021419-nypnib0h	737	7	giving	give	VBG
cord-021419-nypnib0h	737	8	N	N	NNP
cord-021419-nypnib0h	737	9	-	-	HYPH
cord-021419-nypnib0h	737	10	alkyl-13-dihydro	alkyl-13-dihydro	NNP
cord-021419-nypnib0h	737	11	derivatives	derivative	NNS
cord-021419-nypnib0h	737	12	of	of	IN
cord-021419-nypnib0h	737	13	daunorubicin	daunorubicin	NNS
cord-021419-nypnib0h	737	14	(	(	-LRB-
cord-021419-nypnib0h	737	15	137b	137b	NNP
cord-021419-nypnib0h	737	16	)	)	-RRB-
cord-021419-nypnib0h	737	17	and	and	CC
cord-021419-nypnib0h	737	18	carminomycin	carminomycin	NNS
cord-021419-nypnib0h	737	19	(	(	-LRB-
cord-021419-nypnib0h	737	20	139b	139b	NNP
cord-021419-nypnib0h	737	21	)	)	-RRB-
cord-021419-nypnib0h	737	22	,	,	.
cord-021419-nypnib0h	738	1	respectively	respectively	RB
cord-021419-nypnib0h	738	2	(	(	-LRB-
cord-021419-nypnib0h	738	3	Scheme	scheme	NN
cord-021419-nypnib0h	738	4	39	39	CD
cord-021419-nypnib0h	738	5	)	)	-RRB-
cord-021419-nypnib0h	738	6	.	.	.
cord-021419-nypnib0h	739	1	These	these	DT
cord-021419-nypnib0h	739	2	analogues	analogue	NNS
cord-021419-nypnib0h	739	3	are	be	VBP
cord-021419-nypnib0h	739	4	less	less	RBR
cord-021419-nypnib0h	739	5	active	active	JJ
cord-021419-nypnib0h	739	6	than	than	IN
cord-021419-nypnib0h	739	7	the	the	DT
cord-021419-nypnib0h	739	8	related	related	JJ
cord-021419-nypnib0h	739	9	compounds	compound	NNS
cord-021419-nypnib0h	739	10	containing	contain	VBG
cord-021419-nypnib0h	739	11	the	the	DT
cord-021419-nypnib0h	739	12	C(13	C(13	NNP
cord-021419-nypnib0h	739	13	)	)	-RRB-
cord-021419-nypnib0h	739	14	=	=	NFP
cord-021419-nypnib0h	740	1	O	o	UH
cord-021419-nypnib0h	740	2	group	group	NN
cord-021419-nypnib0h	740	3	.	.	.
cord-021419-nypnib0h	741	1	92	92	CD
cord-021419-nypnib0h	742	1	±	±	NNP
cord-021419-nypnib0h	742	2	94	94	CD
cord-021419-nypnib0h	743	1	13-Dimethyl	13-dimethyl	CD
cord-021419-nypnib0h	743	2	ketals	ketal	NNS
cord-021419-nypnib0h	743	3	of	of	IN
cord-021419-nypnib0h	743	4	14-bromo	14-bromo	CD
cord-021419-nypnib0h	743	5	derivatives	derivative	NNS
cord-021419-nypnib0h	743	6	of	of	IN
cord-021419-nypnib0h	743	7	daunorubicin	daunorubicin	NNS
cord-021419-nypnib0h	743	8	(	(	-LRB-
cord-021419-nypnib0h	743	9	137c	137c	NNP
cord-021419-nypnib0h	743	10	)	)	-RRB-
cord-021419-nypnib0h	743	11	and	and	CC
cord-021419-nypnib0h	743	12	carminomycin	carminomycin	NNS
cord-021419-nypnib0h	743	13	(	(	-LRB-
cord-021419-nypnib0h	743	14	139c	139c	CD
cord-021419-nypnib0h	743	15	)	)	-RRB-
cord-021419-nypnib0h	743	16	were	be	VBD
cord-021419-nypnib0h	743	17	used	use	VBN
cord-021419-nypnib0h	743	18	to	to	TO
cord-021419-nypnib0h	743	19	avoid	avoid	VB
cord-021419-nypnib0h	743	20	this	this	DT
cord-021419-nypnib0h	743	21	side	side	NN
cord-021419-nypnib0h	743	22	reaction	reaction	NN
cord-021419-nypnib0h	743	23	(	(	-LRB-
cord-021419-nypnib0h	743	24	see	see	VB
cord-021419-nypnib0h	743	25	Scheme	Scheme	NNP
cord-021419-nypnib0h	743	26	39	39	CD
cord-021419-nypnib0h	743	27	)	)	-RRB-
cord-021419-nypnib0h	743	28	.	.	.
cord-021419-nypnib0h	744	1	The	the	DT
cord-021419-nypnib0h	744	2	reductive	reductive	JJ
cord-021419-nypnib0h	744	3	alkylation	alkylation	NN
cord-021419-nypnib0h	744	4	of	of	IN
cord-021419-nypnib0h	744	5	compounds	compound	NNS
cord-021419-nypnib0h	744	6	137c	137c	CD
cord-021419-nypnib0h	744	7	and	and	CC
cord-021419-nypnib0h	744	8	139c	139c	CD
cord-021419-nypnib0h	744	9	in	in	IN
cord-021419-nypnib0h	744	10	the	the	DT
cord-021419-nypnib0h	744	11	presence	presence	NN
cord-021419-nypnib0h	744	12	of	of	IN
cord-021419-nypnib0h	744	13	NaBH	NaBH	NNP
cord-021419-nypnib0h	744	14	3	3	CD
cord-021419-nypnib0h	744	15	CN	CN	NNP
cord-021419-nypnib0h	744	16	can	can	MD
cord-021419-nypnib0h	744	17	be	be	VB
cord-021419-nypnib0h	744	18	accomplished	accomplish	VBN
cord-021419-nypnib0h	744	19	using	use	VBG
cord-021419-nypnib0h	744	20	D	D	NNP
cord-021419-nypnib0h	744	21	,	,	,
cord-021419-nypnib0h	744	22	Lglyceraldehyde	Lglyceraldehyde	NNP
cord-021419-nypnib0h	744	23	and	and	CC
cord-021419-nypnib0h	744	24	aldoses	aldose	NNS
cord-021419-nypnib0h	744	25	(	(	-LRB-
cord-021419-nypnib0h	744	26	the	the	DT
cord-021419-nypnib0h	744	27	monosaccharide	monosaccharide	NN
cord-021419-nypnib0h	744	28	arabinose	arabinose	NN
cord-021419-nypnib0h	744	29	and	and	CC
cord-021419-nypnib0h	744	30	the	the	DT
cord-021419-nypnib0h	744	31	disaccharide	disaccharide	NN
cord-021419-nypnib0h	744	32	melibiose	melibiose	NNP
cord-021419-nypnib0h	744	33	)	)	-RRB-
cord-021419-nypnib0h	744	34	to	to	TO
cord-021419-nypnib0h	744	35	form	form	VB
cord-021419-nypnib0h	744	36	the	the	DT
cord-021419-nypnib0h	744	37	following	follow	VBG
cord-021419-nypnib0h	744	38	14bromo	14bromo	CD
cord-021419-nypnib0h	744	39	-	-	HYPH
cord-021419-nypnib0h	744	40	substituted	substitute	VBN
cord-021419-nypnib0h	744	41	13-dimethyl	13-dimethyl	CD
cord-021419-nypnib0h	744	42	ketals	ketal	NNS
cord-021419-nypnib0h	744	43	in	in	IN
cord-021419-nypnib0h	744	44	quantitative	quantitative	JJ
cord-021419-nypnib0h	744	45	yields	yield	NNS
cord-021419-nypnib0h	744	46	:	:	:
cord-021419-nypnib0h	744	47	The	the	DT
cord-021419-nypnib0h	744	48	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	744	49	activity	activity	NN
cord-021419-nypnib0h	744	50	of	of	IN
cord-021419-nypnib0h	744	51	compounds	compound	NNS
cord-021419-nypnib0h	744	52	139e	139e	CD
cord-021419-nypnib0h	744	53	and	and	CC
cord-021419-nypnib0h	744	54	143	143	CD
cord-021419-nypnib0h	744	55	against	against	IN
cord-021419-nypnib0h	744	56	leukaemia	leukaemia	NN
cord-021419-nypnib0h	744	57	cells	cell	NNS
cord-021419-nypnib0h	744	58	K562	k562	XX
cord-021419-nypnib0h	744	59	is	be	VBZ
cord-021419-nypnib0h	744	60	virtually	virtually	RB
cord-021419-nypnib0h	744	61	as	as	RB
cord-021419-nypnib0h	744	62	high	high	JJ
cord-021419-nypnib0h	744	63	as	as	IN
cord-021419-nypnib0h	744	64	that	that	DT
cord-021419-nypnib0h	744	65	of	of	IN
cord-021419-nypnib0h	744	66	derivative	derivative	JJ
cord-021419-nypnib0h	744	67	137e	137e	CD
cord-021419-nypnib0h	744	68	,	,	,
cord-021419-nypnib0h	744	69	but	but	CC
cord-021419-nypnib0h	744	70	is	be	VBZ
cord-021419-nypnib0h	744	71	lower	low	JJR
cord-021419-nypnib0h	744	72	than	than	IN
cord-021419-nypnib0h	744	73	that	that	DT
cord-021419-nypnib0h	744	74	of	of	IN
cord-021419-nypnib0h	744	75	carminomycin	carminomycin	NNS
cord-021419-nypnib0h	744	76	(	(	-LRB-
cord-021419-nypnib0h	744	77	139a	139a	NNP
cord-021419-nypnib0h	744	78	)	)	-RRB-
cord-021419-nypnib0h	744	79	.	.	.
cord-021419-nypnib0h	745	1	The	the	DT
cord-021419-nypnib0h	745	2	activity	activity	NN
cord-021419-nypnib0h	745	3	of	of	IN
cord-021419-nypnib0h	745	4	14-hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	745	5	derivative	derivative	JJ
cord-021419-nypnib0h	745	6	143	143	CD
cord-021419-nypnib0h	745	7	evaluated	evaluate	VBN
cord-021419-nypnib0h	745	8	in	in	IN
cord-021419-nypnib0h	745	9	the	the	DT
cord-021419-nypnib0h	745	10	same	same	JJ
cord-021419-nypnib0h	745	11	assay	assay	NN
cord-021419-nypnib0h	745	12	is	be	VBZ
cord-021419-nypnib0h	745	13	an	an	DT
cord-021419-nypnib0h	745	14	order	order	NN
cord-021419-nypnib0h	745	15	of	of	IN
cord-021419-nypnib0h	745	16	magnitude	magnitude	NN
cord-021419-nypnib0h	745	17	lower	low	JJR
cord-021419-nypnib0h	745	18	than	than	IN
cord-021419-nypnib0h	745	19	that	that	DT
cord-021419-nypnib0h	745	20	of	of	IN
cord-021419-nypnib0h	745	21	the	the	DT
cord-021419-nypnib0h	745	22	starting	start	VBG
cord-021419-nypnib0h	745	23	anthracycline	anthracycline	NNP
cord-021419-nypnib0h	745	24	139a	139a	NNP
cord-021419-nypnib0h	745	25	,	,	,
cord-021419-nypnib0h	745	26	and	and	CC
cord-021419-nypnib0h	745	27	the	the	DT
cord-021419-nypnib0h	745	28	activity	activity	NN
cord-021419-nypnib0h	745	29	of	of	IN
cord-021419-nypnib0h	745	30	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	745	31	137e	137e	CD
cord-021419-nypnib0h	745	32	is	be	VBZ
cord-021419-nypnib0h	745	33	two	two	CD
cord-021419-nypnib0h	745	34	orders	order	NNS
cord-021419-nypnib0h	745	35	of	of	IN
cord-021419-nypnib0h	745	36	magnitude	magnitude	NN
cord-021419-nypnib0h	745	37	lower	low	JJR
cord-021419-nypnib0h	745	38	than	than	IN
cord-021419-nypnib0h	745	39	that	that	DT
cord-021419-nypnib0h	745	40	of	of	IN
cord-021419-nypnib0h	745	41	compound	compound	NN
cord-021419-nypnib0h	745	42	138a	138a	CD
cord-021419-nypnib0h	745	43	.	.	.
cord-021419-nypnib0h	746	1	It	-PRON-	PRP
cord-021419-nypnib0h	746	2	should	should	MD
cord-021419-nypnib0h	746	3	be	be	VB
cord-021419-nypnib0h	746	4	emphasized	emphasize	VBN
cord-021419-nypnib0h	746	5	that	that	IN
cord-021419-nypnib0h	746	6	14-hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	746	7	derivatives	derivative	NNS
cord-021419-nypnib0h	746	8	142	142	CD
cord-021419-nypnib0h	746	9	and	and	CC
cord-021419-nypnib0h	746	10	143	143	CD
cord-021419-nypnib0h	746	11	are	be	VBP
cord-021419-nypnib0h	746	12	equally	equally	RB
cord-021419-nypnib0h	746	13	active	active	JJ
cord-021419-nypnib0h	746	14	against	against	IN
cord-021419-nypnib0h	746	15	the	the	DT
cord-021419-nypnib0h	746	16	wildtype	wildtype	JJ
cord-021419-nypnib0h	746	17	human	human	JJ
cord-021419-nypnib0h	746	18	breast	breast	NN
cord-021419-nypnib0h	746	19	adenocarcinoma	adenocarcinoma	NN
cord-021419-nypnib0h	746	20	cell	cell	NN
cord-021419-nypnib0h	746	21	lines	line	NNS
cord-021419-nypnib0h	746	22	MCF-7	MCF-7	NNP
cord-021419-nypnib0h	746	23	and	and	CC
cord-021419-nypnib0h	746	24	K562	k562	CD
cord-021419-nypnib0h	746	25	and	and	CC
cord-021419-nypnib0h	746	26	resistant	resistant	JJ
cord-021419-nypnib0h	746	27	Pgp	Pgp	NNP
cord-021419-nypnib0h	746	28	-	-	HYPH
cord-021419-nypnib0h	746	29	expressing	express	VBG
cord-021419-nypnib0h	746	30	cell	cell	NN
cord-021419-nypnib0h	746	31	lines	line	NNS
cord-021419-nypnib0h	746	32	(	(	-LRB-
cord-021419-nypnib0h	746	33	MCF-7Dox	MCF-7Dox	NNP
cord-021419-nypnib0h	746	34	,	,	,
cord-021419-nypnib0h	746	35	K562i	K562i	NNP
cord-021419-nypnib0h	746	36	/	/	SYM
cord-021419-nypnib0h	746	37	S9	S9	NNP
cord-021419-nypnib0h	746	38	)	)	-RRB-
cord-021419-nypnib0h	746	39	.	.	.
cord-021419-nypnib0h	747	1	The	the	DT
cord-021419-nypnib0h	747	2	antitumour	antitumour	JJ
cord-021419-nypnib0h	747	3	activity	activity	NN
cord-021419-nypnib0h	747	4	of	of	IN
cord-021419-nypnib0h	747	5	compound	compound	NN
cord-021419-nypnib0h	747	6	139e	139e	NNS
cord-021419-nypnib0h	747	7	evaluated	evaluate	VBD
cord-021419-nypnib0h	747	8	in	in	IN
cord-021419-nypnib0h	747	9	the	the	DT
cord-021419-nypnib0h	747	10	murine	murine	JJ
cord-021419-nypnib0h	747	11	leukaemia	leukaemia	NN
cord-021419-nypnib0h	747	12	cell	cell	NN
cord-021419-nypnib0h	747	13	line	line	NN
cord-021419-nypnib0h	747	14	P388	P388	NNP
cord-021419-nypnib0h	747	15	compares	compare	VBZ
cord-021419-nypnib0h	747	16	favourably	favourably	RB
cord-021419-nypnib0h	747	17	with	with	IN
cord-021419-nypnib0h	747	18	that	that	DT
cord-021419-nypnib0h	747	19	of	of	IN
cord-021419-nypnib0h	747	20	analogue	analogue	NN
cord-021419-nypnib0h	747	21	138a	138a	CD
cord-021419-nypnib0h	747	22	.	.	.
cord-021419-nypnib0h	748	1	Thus	thus	RB
cord-021419-nypnib0h	748	2	,	,	,
cord-021419-nypnib0h	748	3	an	an	DT
cord-021419-nypnib0h	748	4	increase	increase	NN
cord-021419-nypnib0h	748	5	in	in	IN
cord-021419-nypnib0h	748	6	life	life	NN
cord-021419-nypnib0h	748	7	span	span	NN
cord-021419-nypnib0h	748	8	(	(	-LRB-
cord-021419-nypnib0h	748	9	ILS	ILS	NNP
cord-021419-nypnib0h	748	10	)	)	-RRB-
cord-021419-nypnib0h	748	11	of	of	IN
cord-021419-nypnib0h	748	12	mice	mouse	NNS
cord-021419-nypnib0h	748	13	bearing	bear	VBG
cord-021419-nypnib0h	748	14	P388	P388	NNP
cord-021419-nypnib0h	748	15	leukaemia	leukaemia	NN
cord-021419-nypnib0h	748	16	after	after	IN
cord-021419-nypnib0h	748	17	a	a	DT
cord-021419-nypnib0h	748	18	single	single	JJ
cord-021419-nypnib0h	748	19	admin	admin	NN
cord-021419-nypnib0h	748	20	-	-	HYPH
cord-021419-nypnib0h	748	21	istration	istration	NN
cord-021419-nypnib0h	748	22	of	of	IN
cord-021419-nypnib0h	748	23	10	10	CD
cord-021419-nypnib0h	748	24	mg	mg	NNP
cord-021419-nypnib0h	748	25	kg	kg	NNP
cord-021419-nypnib0h	748	26	71	71	CD
cord-021419-nypnib0h	748	27	of	of	IN
cord-021419-nypnib0h	748	28	compound	compound	NN
cord-021419-nypnib0h	748	29	139e	139e	NNPS
cord-021419-nypnib0h	748	30	is	be	VBZ
cord-021419-nypnib0h	748	31	the	the	DT
cord-021419-nypnib0h	748	32	same	same	JJ
cord-021419-nypnib0h	748	33	as	as	IN
cord-021419-nypnib0h	748	34	that	that	DT
cord-021419-nypnib0h	748	35	observed	observe	VBD
cord-021419-nypnib0h	748	36	after	after	IN
cord-021419-nypnib0h	748	37	administration	administration	NN
cord-021419-nypnib0h	748	38	of	of	IN
cord-021419-nypnib0h	748	39	analogue	analogue	NNP
cord-021419-nypnib0h	748	40	138a	138a	CD
cord-021419-nypnib0h	748	41	at	at	IN
cord-021419-nypnib0h	748	42	a	a	DT
cord-021419-nypnib0h	748	43	dose	dose	NN
cord-021419-nypnib0h	748	44	of	of	IN
cord-021419-nypnib0h	748	45	8	8	CD
cord-021419-nypnib0h	748	46	mg	mg	NNP
cord-021419-nypnib0h	748	47	kg	kg	NNP
cord-021419-nypnib0h	748	48	71	71	CD
cord-021419-nypnib0h	748	49	(	(	-LRB-
cord-021419-nypnib0h	748	50	ILS	ILS	NNP
cord-021419-nypnib0h	748	51	108	108	CD
cord-021419-nypnib0h	748	52	%	%	NN
cord-021419-nypnib0h	748	53	)	)	-RRB-
cord-021419-nypnib0h	748	54	.	.	.
cord-021419-nypnib0h	749	1	92	92	CD
cord-021419-nypnib0h	750	1	It	-PRON-	PRP
cord-021419-nypnib0h	750	2	was	be	VBD
cord-021419-nypnib0h	750	3	shown	show	VBN
cord-021419-nypnib0h	750	4	that	that	IN
cord-021419-nypnib0h	750	5	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	750	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	750	7	137a	137a	CD
cord-021419-nypnib0h	750	8	,	,	,
cord-021419-nypnib0h	750	9	138a	138a	CD
cord-021419-nypnib0h	750	10	and	and	CC
cord-021419-nypnib0h	750	11	139a	139a	NNPS
cord-021419-nypnib0h	750	12	,	,	,
cord-021419-nypnib0h	750	13	which	which	WDT
cord-021419-nypnib0h	750	14	are	be	VBP
cord-021419-nypnib0h	750	15	known	know	VBN
cord-021419-nypnib0h	750	16	to	to	TO
cord-021419-nypnib0h	750	17	inhibit	inhibit	VB
cord-021419-nypnib0h	750	18	DNA	dna	NN
cord-021419-nypnib0h	750	19	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	750	20	II	II	NNP
cord-021419-nypnib0h	750	21	at	at	IN
cord-021419-nypnib0h	750	22	micromolar	micromolar	JJ
cord-021419-nypnib0h	750	23	concentrations	concentration	NNS
cord-021419-nypnib0h	750	24	,	,	,
cord-021419-nypnib0h	750	25	can	can	MD
cord-021419-nypnib0h	750	26	inhibit	inhibit	VB
cord-021419-nypnib0h	750	27	DNA	dna	NN
cord-021419-nypnib0h	751	1	topoisomerase	topoisomerase	NNP
cord-021419-nypnib0h	752	1	I	-PRON-	PRP
cord-021419-nypnib0h	752	2	at	at	IN
cord-021419-nypnib0h	752	3	the	the	DT
cord-021419-nypnib0h	752	4	same	same	JJ
cord-021419-nypnib0h	752	5	concentrations	concentration	NNS
cord-021419-nypnib0h	752	6	.	.	.
cord-021419-nypnib0h	753	1	75	75	CD
cord-021419-nypnib0h	753	2	New	new	JJ
cord-021419-nypnib0h	753	3	derivatives	derivative	NNS
cord-021419-nypnib0h	753	4	137e	137e	CD
cord-021419-nypnib0h	753	5	,	,	,
cord-021419-nypnib0h	753	6	139e	139e	CD
cord-021419-nypnib0h	753	7	,	,	,
cord-021419-nypnib0h	753	8	142	142	CD
cord-021419-nypnib0h	753	9	and	and	CC
cord-021419-nypnib0h	753	10	143	143	CD
cord-021419-nypnib0h	753	11	have	have	VBP
cord-021419-nypnib0h	753	12	higher	high	JJR
cord-021419-nypnib0h	753	13	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	753	14	activity	activity	NN
cord-021419-nypnib0h	753	15	against	against	IN
cord-021419-nypnib0h	753	16	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	754	1	I	-PRON-	PRP
cord-021419-nypnib0h	754	2	compared	compare	VBD
cord-021419-nypnib0h	754	3	to	to	IN
cord-021419-nypnib0h	754	4	compounds	compound	NNS
cord-021419-nypnib0h	754	5	138a	138a	CD
cord-021419-nypnib0h	754	6	and	and	CC
cord-021419-nypnib0h	754	7	139a	139a	CD
cord-021419-nypnib0h	754	8	.	.	.
cord-021419-nypnib0h	755	1	The	the	DT
cord-021419-nypnib0h	755	2	introduction	introduction	NN
cord-021419-nypnib0h	755	3	of	of	IN
cord-021419-nypnib0h	755	4	polyhydroxylated	polyhydroxylated	JJ
cord-021419-nypnib0h	755	5	substituents	substituent	NNS
cord-021419-nypnib0h	755	6	at	at	IN
cord-021419-nypnib0h	755	7	the	the	DT
cord-021419-nypnib0h	755	8	3	3	CD
cord-021419-nypnib0h	755	9	H	h	NN
cord-021419-nypnib0h	755	10	-amino	-amino	HYPH
cord-021419-nypnib0h	755	11	group	group	NN
cord-021419-nypnib0h	755	12	of	of	IN
cord-021419-nypnib0h	755	13	the	the	DT
cord-021419-nypnib0h	755	14	daunosamine	daunosamine	NNP
cord-021419-nypnib0h	755	15	moiety	moiety	NNP
cord-021419-nypnib0h	755	16	of	of	IN
cord-021419-nypnib0h	755	17	anthracycline	anthracycline	NNP
cord-021419-nypnib0h	755	18	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	755	19	increases	increase	VBZ
cord-021419-nypnib0h	755	20	the	the	DT
cord-021419-nypnib0h	755	21	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	755	22	activity	activity	NN
cord-021419-nypnib0h	755	23	of	of	IN
cord-021419-nypnib0h	755	24	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	755	25	against	against	IN
cord-021419-nypnib0h	755	26	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	755	27	 	 	_SP
cord-021419-nypnib0h	756	1	A	a	DT
cord-021419-nypnib0h	756	2	method	method	NN
cord-021419-nypnib0h	756	3	was	be	VBD
cord-021419-nypnib0h	756	4	developed	develop	VBN
cord-021419-nypnib0h	756	5	for	for	IN
cord-021419-nypnib0h	756	6	the	the	DT
cord-021419-nypnib0h	756	7	preparation	preparation	NN
cord-021419-nypnib0h	756	8	of	of	IN
cord-021419-nypnib0h	756	9	new	new	JJ
cord-021419-nypnib0h	756	10	watersoluble	watersoluble	NNP
cord-021419-nypnib0h	756	11	depot	depot	NN
cord-021419-nypnib0h	756	12	forms	form	NNS
cord-021419-nypnib0h	756	13	of	of	IN
cord-021419-nypnib0h	757	1	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	757	2	(	(	-LRB-
cord-021419-nypnib0h	757	3	138a	138a	CD
cord-021419-nypnib0h	757	4	)	)	-RRB-
cord-021419-nypnib0h	757	5	Ð	ð	NN
cord-021419-nypnib0h	757	6	conjugates	conjugate	NNS
cord-021419-nypnib0h	757	7	with	with	IN
cord-021419-nypnib0h	757	8	high	high	JJ
cord-021419-nypnib0h	757	9	-	-	HYPH
cord-021419-nypnib0h	757	10	molecular	molecular	JJ
cord-021419-nypnib0h	757	11	-	-	HYPH
cord-021419-nypnib0h	757	12	mass	mass	NN
cord-021419-nypnib0h	757	13	polysaccharides	polysaccharide	NNS
cord-021419-nypnib0h	757	14	.	.	.
cord-021419-nypnib0h	758	1	95	95	CD
cord-021419-nypnib0h	758	2	,	,	,
cord-021419-nypnib0h	758	3	96	96	CD
cord-021419-nypnib0h	758	4	Galactomannan	Galactomannan	NNP
cord-021419-nypnib0h	758	5	DAVANAT	DAVANAT	NNP
cord-021419-nypnib0h	758	6	(	(	-LRB-
cord-021419-nypnib0h	758	7	144	144	CD
cord-021419-nypnib0h	758	8	)	)	-RRB-
cord-021419-nypnib0h	758	9	was	be	VBD
cord-021419-nypnib0h	758	10	used	use	VBN
cord-021419-nypnib0h	758	11	as	as	IN
cord-021419-nypnib0h	758	12	the	the	DT
cord-021419-nypnib0h	758	13	polysaccharide	polysaccharide	NN
cord-021419-nypnib0h	758	14	.	.	.
cord-021419-nypnib0h	759	1	The	the	DT
cord-021419-nypnib0h	759	2	latter	latter	JJ
cord-021419-nypnib0h	759	3	was	be	VBD
cord-021419-nypnib0h	759	4	prepared	prepare	VBN
cord-021419-nypnib0h	759	5	by	by	IN
cord-021419-nypnib0h	759	6	controlled	control	VBN
cord-021419-nypnib0h	759	7	partial	partial	JJ
cord-021419-nypnib0h	759	8	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	759	9	of	of	IN
cord-021419-nypnib0h	759	10	water	water	NN
cord-021419-nypnib0h	759	11	-	-	HYPH
cord-021419-nypnib0h	759	12	insoluble	insoluble	JJ
cord-021419-nypnib0h	759	13	high	high	JJ
cord-021419-nypnib0h	759	14	-	-	HYPH
cord-021419-nypnib0h	759	15	molecular	molecular	JJ
cord-021419-nypnib0h	759	16	-	-	HYPH
cord-021419-nypnib0h	759	17	mass	mass	NN
cord-021419-nypnib0h	759	18	1,4-b	1,4-b	CD
cord-021419-nypnib0h	759	19	-	-	HYPH
cord-021419-nypnib0h	759	20	D	d	NN
cord-021419-nypnib0h	759	21	-	-	HYPH
cord-021419-nypnib0h	759	22	galactomannan	galactomannan	NNP
cord-021419-nypnib0h	759	23	isolated	isolate	VBN
cord-021419-nypnib0h	759	24	from	from	IN
cord-021419-nypnib0h	759	25	seeds	seed	NNS
cord-021419-nypnib0h	759	26	of	of	IN
cord-021419-nypnib0h	759	27	Cyamopsis	Cyamopsis	NNP
cord-021419-nypnib0h	759	28	tetragonoloba	tetragonoloba	NN
cord-021419-nypnib0h	759	29	or	or	CC
cord-021419-nypnib0h	759	30	Guar	Guar	NNP
cord-021419-nypnib0h	759	31	gum	gum	NN
cord-021419-nypnib0h	759	32	.	.	.
cord-021419-nypnib0h	760	1	The	the	DT
cord-021419-nypnib0h	760	2	molecular	molecular	JJ
cord-021419-nypnib0h	760	3	mass	mass	NN
cord-021419-nypnib0h	760	4	of	of	IN
cord-021419-nypnib0h	760	5	compound	compound	NN
cord-021419-nypnib0h	760	6	144	144	CD
cord-021419-nypnib0h	760	7	,	,	,
cord-021419-nypnib0h	760	8	determined	determine	VBN
cord-021419-nypnib0h	760	9	by	by	IN
cord-021419-nypnib0h	760	10	gel	gel	NN
cord-021419-nypnib0h	760	11	chromatography	chromatography	NN
cord-021419-nypnib0h	760	12	on	on	IN
cord-021419-nypnib0h	760	13	a	a	DT
cord-021419-nypnib0h	760	14	Sephadex	Sephadex	NNP
cord-021419-nypnib0h	760	15	G-200	g-200	IN
cord-021419-nypnib0h	760	16	column	column	NN
cord-021419-nypnib0h	760	17	calibrated	calibrate	VBN
cord-021419-nypnib0h	760	18	with	with	IN
cord-021419-nypnib0h	760	19	pullulans	pullulan	NNS
cord-021419-nypnib0h	760	20	,	,	,
cord-021419-nypnib0h	760	21	is	be	VBZ
cord-021419-nypnib0h	760	22	*	*	NFP
cord-021419-nypnib0h	760	23	92	92	CD
cord-021419-nypnib0h	760	24	kDa	kDa	NNS
cord-021419-nypnib0h	760	25	.	.	.
cord-021419-nypnib0h	761	1	To	to	TO
cord-021419-nypnib0h	761	2	conjugate	conjugate	VB
cord-021419-nypnib0h	761	3	compound	compound	NN
cord-021419-nypnib0h	761	4	144	144	CD
cord-021419-nypnib0h	761	5	with	with	IN
cord-021419-nypnib0h	761	6	138a	138a	CD
cord-021419-nypnib0h	762	1	,	,	,
cord-021419-nypnib0h	762	2	the	the	DT
cord-021419-nypnib0h	762	3	former	former	JJ
cord-021419-nypnib0h	762	4	is	be	VBZ
cord-021419-nypnib0h	762	5	activated	activate	VBN
cord-021419-nypnib0h	762	6	by	by	IN
cord-021419-nypnib0h	762	7	the	the	DT
cord-021419-nypnib0h	762	8	oxidation	oxidation	NN
cord-021419-nypnib0h	762	9	with	with	IN
cord-021419-nypnib0h	762	10	periodate	periodate	NNP
cord-021419-nypnib0h	762	11	using	use	VBG
cord-021419-nypnib0h	762	12	a	a	DT
cord-021419-nypnib0h	762	13	deficient	deficient	JJ
cord-021419-nypnib0h	762	14	amount	amount	NN
cord-021419-nypnib0h	762	15	of	of	IN
cord-021419-nypnib0h	762	16	the	the	DT
cord-021419-nypnib0h	762	17	oxidizing	oxidizing	JJ
cord-021419-nypnib0h	762	18	agent	agent	NN
cord-021419-nypnib0h	762	19	(	(	-LRB-
cord-021419-nypnib0h	762	20	0.07	0.07	CD
cord-021419-nypnib0h	762	21	±	±	CD
cord-021419-nypnib0h	762	22	0.11	0.11	CD
cord-021419-nypnib0h	762	23	equiv	equiv	NN
cord-021419-nypnib0h	762	24	.	.	.
cord-021419-nypnib0h	763	1	with	with	IN
cord-021419-nypnib0h	763	2	respect	respect	NN
cord-021419-nypnib0h	763	3	to	to	IN
cord-021419-nypnib0h	763	4	the	the	DT
cord-021419-nypnib0h	763	5	total	total	JJ
cord-021419-nypnib0h	763	6	amount	amount	NN
cord-021419-nypnib0h	763	7	of	of	IN
cord-021419-nypnib0h	763	8	sugar	sugar	NN
cord-021419-nypnib0h	763	9	residues	residue	NNS
cord-021419-nypnib0h	763	10	)	)	-RRB-
cord-021419-nypnib0h	763	11	.	.	.
cord-021419-nypnib0h	764	1	This	this	DT
cord-021419-nypnib0h	764	2	gives	give	VBZ
cord-021419-nypnib0h	764	3	rise	rise	NN
cord-021419-nypnib0h	764	4	to	to	IN
cord-021419-nypnib0h	764	5	Schiff	Schiff	NNP
cord-021419-nypnib0h	764	6	bases	basis	NNS
cord-021419-nypnib0h	764	7	between	between	IN
cord-021419-nypnib0h	764	8	the	the	DT
cord-021419-nypnib0h	764	9	aldehyde	aldehyde	NN
cord-021419-nypnib0h	764	10	groups	group	NNS
cord-021419-nypnib0h	764	11	of	of	IN
cord-021419-nypnib0h	764	12	the	the	DT
cord-021419-nypnib0h	764	13	oxidized	oxidized	JJ
cord-021419-nypnib0h	764	14	polysaccharide	polysaccharide	NN
cord-021419-nypnib0h	764	15	(	(	-LRB-
cord-021419-nypnib0h	764	16	145a	145a	NNP
cord-021419-nypnib0h	764	17	±	±	NNP
cord-021419-nypnib0h	764	18	145c	145c	NNP
cord-021419-nypnib0h	764	19	)	)	-RRB-
cord-021419-nypnib0h	764	20	and	and	CC
cord-021419-nypnib0h	764	21	the	the	DT
cord-021419-nypnib0h	764	22	3	3	CD
cord-021419-nypnib0h	764	23	H	H	NNP
cord-021419-nypnib0h	764	24	-amino	-amino	HYPH
cord-021419-nypnib0h	764	25	group	group	NN
cord-021419-nypnib0h	764	26	of	of	IN
cord-021419-nypnib0h	764	27	the	the	DT
cord-021419-nypnib0h	764	28	antibiotic	antibiotic	NN
cord-021419-nypnib0h	764	29	(	(	-LRB-
cord-021419-nypnib0h	764	30	Scheme	scheme	NN
cord-021419-nypnib0h	764	31	40	40	CD
cord-021419-nypnib0h	764	32	)	)	-RRB-
cord-021419-nypnib0h	764	33	.	.	.
cord-021419-nypnib0h	765	1	Different	different	JJ
cord-021419-nypnib0h	765	2	structures	structure	NNS
cord-021419-nypnib0h	765	3	of	of	IN
cord-021419-nypnib0h	765	4	the	the	DT
cord-021419-nypnib0h	765	5	final	final	JJ
cord-021419-nypnib0h	765	6	products	product	NNS
cord-021419-nypnib0h	765	7	are	be	VBP
cord-021419-nypnib0h	765	8	possible	possible	JJ
cord-021419-nypnib0h	766	1	(	(	-LRB-
cord-021419-nypnib0h	766	2	146a	146a	NNP
cord-021419-nypnib0h	766	3	±	±	NNP
cord-021419-nypnib0h	766	4	146c	146c	NNP
cord-021419-nypnib0h	766	5	)	)	-RRB-
cord-021419-nypnib0h	766	6	.	.	.
cord-021419-nypnib0h	767	1	The	the	DT
cord-021419-nypnib0h	767	2	content	content	NN
cord-021419-nypnib0h	767	3	of	of	IN
cord-021419-nypnib0h	767	4	the	the	DT
cord-021419-nypnib0h	767	5	starting	start	VBG
cord-021419-nypnib0h	767	6	antibiotic	antibiotic	NN
cord-021419-nypnib0h	767	7	138a	138a	CD
cord-021419-nypnib0h	767	8	in	in	IN
cord-021419-nypnib0h	767	9	conjugate	conjugate	NN
cord-021419-nypnib0h	767	10	146	146	CD
cord-021419-nypnib0h	767	11	is	be	VBZ
cord-021419-nypnib0h	767	12	5	5	CD
cord-021419-nypnib0h	767	13	mass	mass	NN
cord-021419-nypnib0h	767	14	%	%	NN
cord-021419-nypnib0h	767	15	(	(	-LRB-
cord-021419-nypnib0h	767	16	determined	determine	VBN
cord-021419-nypnib0h	767	17	from	from	IN
cord-021419-nypnib0h	767	18	the	the	DT
cord-021419-nypnib0h	767	19	content	content	NN
cord-021419-nypnib0h	767	20	of	of	IN
cord-021419-nypnib0h	767	21	the	the	DT
cord-021419-nypnib0h	767	22	chromophore	chromophore	NN
cord-021419-nypnib0h	767	23	per	per	IN
cord-021419-nypnib0h	767	24	unit	unit	NN
cord-021419-nypnib0h	767	25	mass	mass	NN
cord-021419-nypnib0h	767	26	of	of	IN
cord-021419-nypnib0h	767	27	the	the	DT
cord-021419-nypnib0h	767	28	dried	dry	VBN
cord-021419-nypnib0h	767	29	powder	powder	NN
cord-021419-nypnib0h	767	30	by	by	IN
cord-021419-nypnib0h	767	31	UV	uv	NN
cord-021419-nypnib0h	767	32	spectroscopy	spectroscopy	NN
cord-021419-nypnib0h	767	33	at	at	IN
cord-021419-nypnib0h	767	34	490	490	CD
cord-021419-nypnib0h	767	35	nm	nm	NN
cord-021419-nypnib0h	767	36	)	)	-RRB-
cord-021419-nypnib0h	767	37	.	.	.
cord-021419-nypnib0h	768	1	In	in	IN
cord-021419-nypnib0h	768	2	order	order	NN
cord-021419-nypnib0h	768	3	to	to	TO
cord-021419-nypnib0h	768	4	increase	increase	VB
cord-021419-nypnib0h	768	5	the	the	DT
cord-021419-nypnib0h	768	6	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	768	7	content	content	NN
cord-021419-nypnib0h	768	8	in	in	IN
cord-021419-nypnib0h	768	9	the	the	DT
cord-021419-nypnib0h	768	10	conjugate	conjugate	NN
cord-021419-nypnib0h	768	11	with	with	IN
cord-021419-nypnib0h	768	12	DAVANAT	DAVANAT	NNP
cord-021419-nypnib0h	768	13	145	145	CD
cord-021419-nypnib0h	768	14	,	,	,
cord-021419-nypnib0h	768	15	the	the	DT
cord-021419-nypnib0h	768	16	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	768	17	molecule	molecule	NN
cord-021419-nypnib0h	768	18	was	be	VBD
cord-021419-nypnib0h	768	19	attached	attach	VBN
cord-021419-nypnib0h	768	20	to	to	IN
cord-021419-nypnib0h	768	21	the	the	DT
cord-021419-nypnib0h	768	22	polysaccharide	polysaccharide	NN
cord-021419-nypnib0h	768	23	through	through	IN
cord-021419-nypnib0h	768	24	a	a	DT
cord-021419-nypnib0h	768	25	spacer	spacer	NN
cord-021419-nypnib0h	768	26	giving	give	VBG
cord-021419-nypnib0h	768	27	3	3	CD
cord-021419-nypnib0h	768	28	H	h	NN
cord-021419-nypnib0h	768	29	-N	-n	NN
cord-021419-nypnib0h	768	30	-	-	HYPH
cord-021419-nypnib0h	768	31	L	l	NN
cord-021419-nypnib0h	768	32	-	-	HYPH
cord-021419-nypnib0h	768	33	lysyldoxorubicin	lysyldoxorubicin	NNS
cord-021419-nypnib0h	768	34	(	(	-LRB-
cord-021419-nypnib0h	768	35	147	147	CD
cord-021419-nypnib0h	768	36	)	)	-RRB-
cord-021419-nypnib0h	768	37	(	(	-LRB-
cord-021419-nypnib0h	768	38	Scheme	scheme	NN
cord-021419-nypnib0h	768	39	41	41	CD
cord-021419-nypnib0h	768	40	)	)	-RRB-
cord-021419-nypnib0h	768	41	.	.	.
cord-021419-nypnib0h	769	1	96	96	CD
cord-021419-nypnib0h	769	2	Compound	compound	NN
cord-021419-nypnib0h	769	3	147	147	CD
cord-021419-nypnib0h	769	4	contains	contain	VBZ
cord-021419-nypnib0h	769	5	two	two	CD
cord-021419-nypnib0h	769	6	amino	amino	NN
cord-021419-nypnib0h	769	7	groups	group	NNS
cord-021419-nypnib0h	769	8	(	(	-LRB-
cord-021419-nypnib0h	769	9	while	while	IN
cord-021419-nypnib0h	769	10	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	769	11	contains	contain	VBZ
cord-021419-nypnib0h	769	12	one	one	CD
cord-021419-nypnib0h	769	13	amino	amino	NN
cord-021419-nypnib0h	769	14	group	group	NN
cord-021419-nypnib0h	769	15	)	)	-RRB-
cord-021419-nypnib0h	769	16	,	,	,
cord-021419-nypnib0h	769	17	which	which	WDT
cord-021419-nypnib0h	769	18	may	may	MD
cord-021419-nypnib0h	769	19	facilitate	facilitate	VB
cord-021419-nypnib0h	769	20	the	the	DT
cord-021419-nypnib0h	769	21	formation	formation	NN
cord-021419-nypnib0h	769	22	of	of	IN
cord-021419-nypnib0h	769	23	the	the	DT
cord-021419-nypnib0h	769	24	Schiff	Schiff	NNP
cord-021419-nypnib0h	769	25	base	base	NN
cord-021419-nypnib0h	769	26	.	.	.
cord-021419-nypnib0h	770	1	Besides	besides	RB
cord-021419-nypnib0h	770	2	,	,	,
cord-021419-nypnib0h	770	3	it	-PRON-	PRP
cord-021419-nypnib0h	770	4	is	be	VBZ
cord-021419-nypnib0h	770	5	known	know	VBN
cord-021419-nypnib0h	770	6	that	that	IN
cord-021419-nypnib0h	770	7	a	a	DT
cord-021419-nypnib0h	770	8	series	series	NN
cord-021419-nypnib0h	770	9	of	of	IN
cord-021419-nypnib0h	770	10	N	N	NNP
cord-021419-nypnib0h	770	11	-	-	HYPH
cord-021419-nypnib0h	770	12	acyl	acyl	NNP
cord-021419-nypnib0h	770	13	conjugates	conjugate	NNS
cord-021419-nypnib0h	770	14	of	of	IN
cord-021419-nypnib0h	770	15	daunorubicin	daunorubicin	NNS
cord-021419-nypnib0h	770	16	or	or	CC
cord-021419-nypnib0h	770	17	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	770	18	with	with	IN
cord-021419-nypnib0h	770	19	amino	amino	JJ
cord-021419-nypnib0h	770	20	acids	acid	NNS
cord-021419-nypnib0h	770	21	possess	possess	VBP
cord-021419-nypnib0h	770	22	high	high	JJ
cord-021419-nypnib0h	770	23	antitumour	antitumour	JJ
cord-021419-nypnib0h	770	24	activity	activity	NN
cord-021419-nypnib0h	770	25	.	.	.
cord-021419-nypnib0h	771	1	90	90	CD
cord-021419-nypnib0h	771	2	3	3	CD
cord-021419-nypnib0h	771	3	H	h	NN
cord-021419-nypnib0h	771	4	-N	-n	NN
cord-021419-nypnib0h	771	5	-	-	HYPH
cord-021419-nypnib0h	771	6	L	L	NNP
cord-021419-nypnib0h	771	7	-	-	HYPH
cord-021419-nypnib0h	771	8	Lysyldoxorubicin	Lysyldoxorubicin	NNP
cord-021419-nypnib0h	771	9	(	(	-LRB-
cord-021419-nypnib0h	771	10	147	147	CD
cord-021419-nypnib0h	771	11	)	)	-RRB-
cord-021419-nypnib0h	771	12	was	be	VBD
cord-021419-nypnib0h	771	13	synthesized	synthesize	VBN
cord-021419-nypnib0h	771	14	by	by	IN
cord-021419-nypnib0h	771	15	the	the	DT
cord-021419-nypnib0h	771	16	acylation	acylation	NN
cord-021419-nypnib0h	771	17	of	of	IN
cord-021419-nypnib0h	771	18	the	the	DT
cord-021419-nypnib0h	771	19	amino	amino	NN
cord-021419-nypnib0h	771	20	group	group	NN
cord-021419-nypnib0h	771	21	of	of	IN
cord-021419-nypnib0h	771	22	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	771	23	(	(	-LRB-
cord-021419-nypnib0h	771	24	138a	138a	CD
cord-021419-nypnib0h	771	25	)	)	-RRB-
cord-021419-nypnib0h	771	26	with	with	IN
cord-021419-nypnib0h	771	27	N	N	NNP
cord-021419-nypnib0h	771	28	a	a	NNP
cord-021419-nypnib0h	771	29	,	,	,
cord-021419-nypnib0h	771	30	N	N	NNP
cord-021419-nypnib0h	771	31	e	e	NN
cord-021419-nypnib0h	771	32	-(Fmoc	-(fmoc	NN
cord-021419-nypnib0h	771	33	)	)	-RRB-
cord-021419-nypnib0h	771	34	2	2	CD
cord-021419-nypnib0h	771	35	-L	-l	XX
cord-021419-nypnib0h	771	36	-	-	HYPH
cord-021419-nypnib0h	771	37	lysine	lysine	JJ
cord-021419-nypnib0h	771	38	OSu	osu	NN
cord-021419-nypnib0h	771	39	-	-	HYPH
cord-021419-nypnib0h	771	40	ester	ester	NN
cord-021419-nypnib0h	771	41	followed	follow	VBN
cord-021419-nypnib0h	771	42	by	by	IN
cord-021419-nypnib0h	771	43	the	the	DT
cord-021419-nypnib0h	771	44	deprotection	deprotection	NN
cord-021419-nypnib0h	771	45	of	of	IN
cord-021419-nypnib0h	771	46	the	the	DT
cord-021419-nypnib0h	771	47	Fmoc	Fmoc	NNP
cord-021419-nypnib0h	771	48	-	-	HYPH
cord-021419-nypnib0h	771	49	protected	protect	VBN
cord-021419-nypnib0h	771	50	intermediate	intermediate	NN
cord-021419-nypnib0h	771	51	with	with	IN
cord-021419-nypnib0h	771	52	a	a	DT
cord-021419-nypnib0h	771	53	morpholine	morpholine	NN
cord-021419-nypnib0h	771	54	solution	solution	NN
cord-021419-nypnib0h	771	55	.	.	.
cord-021419-nypnib0h	772	1	96	96	CD
cord-021419-nypnib0h	773	1	The	the	DT
cord-021419-nypnib0h	773	2	Schiff	Schiff	NNP
cord-021419-nypnib0h	773	3	base	base	NN
cord-021419-nypnib0h	773	4	in	in	IN
cord-021419-nypnib0h	773	5	the	the	DT
cord-021419-nypnib0h	773	6	resulting	result	VBG
cord-021419-nypnib0h	773	7	conjugate	conjugate	NN
cord-021419-nypnib0h	773	8	can	can	MD
cord-021419-nypnib0h	773	9	have	have	VB
cord-021419-nypnib0h	773	10	either	either	CC
cord-021419-nypnib0h	773	11	a	a	DT
cord-021419-nypnib0h	773	12	linear	linear	NN
cord-021419-nypnib0h	773	13	(	(	-LRB-
cord-021419-nypnib0h	773	14	148a	148a	CD
cord-021419-nypnib0h	773	15	)	)	-RRB-
cord-021419-nypnib0h	773	16	or	or	CC
cord-021419-nypnib0h	773	17	cyclic	cyclic	JJ
cord-021419-nypnib0h	773	18	structure	structure	NN
cord-021419-nypnib0h	773	19	(	(	-LRB-
cord-021419-nypnib0h	773	20	148b	148b	CD
cord-021419-nypnib0h	773	21	)	)	-RRB-
cord-021419-nypnib0h	773	22	.	.	.
cord-021419-nypnib0h	774	1	Scheme	scheme	NN
cord-021419-nypnib0h	774	2	41	41	CD
cord-021419-nypnib0h	774	3	presents	present	VBZ
cord-021419-nypnib0h	774	4	the	the	DT
cord-021419-nypnib0h	774	5	possible	possible	JJ
cord-021419-nypnib0h	774	6	structures	structure	NNS
cord-021419-nypnib0h	774	7	for	for	IN
cord-021419-nypnib0h	774	8	one	one	CD
cord-021419-nypnib0h	774	9	of	of	IN
cord-021419-nypnib0h	774	10	the	the	DT
cord-021419-nypnib0h	774	11	oxidized	oxidize	VBN
cord-021419-nypnib0h	774	12	subunits	subunit	NNS
cord-021419-nypnib0h	774	13	of	of	IN
cord-021419-nypnib0h	774	14	activated	activate	VBN
cord-021419-nypnib0h	774	15	DAVANAT	DAVANAT	NNP
cord-021419-nypnib0h	774	16	145	145	CD
cord-021419-nypnib0h	774	17	.	.	.
cord-021419-nypnib0h	775	1	It	-PRON-	PRP
cord-021419-nypnib0h	775	2	should	should	MD
cord-021419-nypnib0h	775	3	be	be	VB
cord-021419-nypnib0h	775	4	noted	note	VBN
cord-021419-nypnib0h	775	5	that	that	IN
cord-021419-nypnib0h	775	6	3	3	CD
cord-021419-nypnib0h	775	7	H	h	NN
cord-021419-nypnib0h	775	8	-N	-n	NN
cord-021419-nypnib0h	775	9	-	-	HYPH
cord-021419-nypnib0h	775	10	L	l	NN
cord-021419-nypnib0h	775	11	-	-	HYPH
cord-021419-nypnib0h	775	12	lysyldoxorubicin	lysyldoxorubicin	NNS
cord-021419-nypnib0h	775	13	can	can	MD
cord-021419-nypnib0h	775	14	be	be	VB
cord-021419-nypnib0h	775	15	attached	attach	VBN
cord-021419-nypnib0h	775	16	to	to	TO
cord-021419-nypnib0h	775	17	conjugate	conjugate	VB
cord-021419-nypnib0h	775	18	145	145	CD
cord-021419-nypnib0h	775	19	through	through	IN
cord-021419-nypnib0h	775	20	either	either	CC
cord-021419-nypnib0h	775	21	the	the	DT
cord-021419-nypnib0h	775	22	a	a	DT
cord-021419-nypnib0h	775	23	-	-	HYPH
cord-021419-nypnib0h	775	24	amino	amino	NN
cord-021419-nypnib0h	775	25	-	-	:
cord-021419-nypnib0h	775	26	or	or	CC
cord-021419-nypnib0h	775	27	e	e	NN
cord-021419-nypnib0h	775	28	-	-	NN
cord-021419-nypnib0h	775	29	amino	amino	JJ
cord-021419-nypnib0h	775	30	group	group	NN
cord-021419-nypnib0h	775	31	of	of	IN
cord-021419-nypnib0h	775	32	3	3	CD
cord-021419-nypnib0h	775	33	H	h	NN
cord-021419-nypnib0h	775	34	-N	-n	NN
cord-021419-nypnib0h	775	35	-	-	HYPH
cord-021419-nypnib0h	775	36	L	l	NN
cord-021419-nypnib0h	775	37	-	-	HYPH
cord-021419-nypnib0h	775	38	lysyldoxorubicin	lysyldoxorubicin	NNP
cord-021419-nypnib0h	775	39	(	(	-LRB-
cord-021419-nypnib0h	775	40	is	be	VBZ
cord-021419-nypnib0h	775	41	not	not	RB
cord-021419-nypnib0h	775	42	shown	show	VBN
cord-021419-nypnib0h	775	43	in	in	IN
cord-021419-nypnib0h	775	44	Scheme	Scheme	NNP
cord-021419-nypnib0h	775	45	41	41	CD
cord-021419-nypnib0h	775	46	)	)	-RRB-
cord-021419-nypnib0h	775	47	.	.	.
cord-021419-nypnib0h	776	1	The	the	DT
cord-021419-nypnib0h	776	2	introduction	introduction	NN
cord-021419-nypnib0h	776	3	of	of	IN
cord-021419-nypnib0h	776	4	the	the	DT
cord-021419-nypnib0h	776	5	lysine	lysine	NN
cord-021419-nypnib0h	776	6	spacer	spacer	NN
cord-021419-nypnib0h	776	7	between	between	IN
cord-021419-nypnib0h	776	8	compounds	compound	NNS
cord-021419-nypnib0h	776	9	138a	138a	CD
cord-021419-nypnib0h	776	10	and	and	CC
cord-021419-nypnib0h	776	11	145	145	CD
cord-021419-nypnib0h	776	12	allows	allow	VBZ
cord-021419-nypnib0h	776	13	an	an	DT
cord-021419-nypnib0h	776	14	increase	increase	NN
cord-021419-nypnib0h	776	15	in	in	IN
cord-021419-nypnib0h	776	16	the	the	DT
cord-021419-nypnib0h	776	17	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	776	18	content	content	NN
cord-021419-nypnib0h	776	19	in	in	IN
cord-021419-nypnib0h	776	20	the	the	DT
cord-021419-nypnib0h	776	21	conjugate	conjugate	NN
cord-021419-nypnib0h	776	22	to	to	IN
cord-021419-nypnib0h	776	23	10	10	CD
cord-021419-nypnib0h	776	24	mass	mass	NN
cord-021419-nypnib0h	776	25	%	%	NN
cord-021419-nypnib0h	776	26	with	with	IN
cord-021419-nypnib0h	776	27	retention	retention	NN
cord-021419-nypnib0h	776	28	of	of	IN
cord-021419-nypnib0h	776	29	water	water	NN
cord-021419-nypnib0h	776	30	solubility	solubility	NN
cord-021419-nypnib0h	776	31	.	.	.
cord-021419-nypnib0h	777	1	The	the	DT
cord-021419-nypnib0h	777	2	conjugates	conjugate	NNS
cord-021419-nypnib0h	777	3	were	be	VBD
cord-021419-nypnib0h	777	4	purified	purify	VBN
cord-021419-nypnib0h	777	5	by	by	IN
cord-021419-nypnib0h	777	6	gel	gel	NN
cord-021419-nypnib0h	777	7	chromatography	chromatography	NN
cord-021419-nypnib0h	777	8	on	on	IN
cord-021419-nypnib0h	777	9	a	a	DT
cord-021419-nypnib0h	777	10	Sephadex	Sephadex	NNP
cord-021419-nypnib0h	777	11	G-200	g-200	IN
cord-021419-nypnib0h	777	12	column	column	NN
cord-021419-nypnib0h	777	13	and	and	CC
cord-021419-nypnib0h	777	14	dialysis	dialysis	NN
cord-021419-nypnib0h	777	15	against	against	IN
cord-021419-nypnib0h	777	16	deionized	deionized	JJ
cord-021419-nypnib0h	777	17	water	water	NN
cord-021419-nypnib0h	777	18	using	use	VBG
cord-021419-nypnib0h	777	19	a	a	DT
cord-021419-nypnib0h	777	20	membrane	membrane	NN
cord-021419-nypnib0h	777	21	with	with	IN
cord-021419-nypnib0h	777	22	molecular	molecular	JJ
cord-021419-nypnib0h	777	23	weight	weight	NN
cord-021419-nypnib0h	777	24	cut	cut	NN
cord-021419-nypnib0h	777	25	-	-	HYPH
cord-021419-nypnib0h	777	26	off	off	NN
cord-021419-nypnib0h	777	27	(	(	-LRB-
cord-021419-nypnib0h	777	28	MWCO	MWCO	NNP
cord-021419-nypnib0h	777	29	)	)	-RRB-
cord-021419-nypnib0h	778	1	M	M	NNP
cord-021419-nypnib0h	779	1	w	w	NN
cord-021419-nypnib0h	779	2	>	>	XX
cord-021419-nypnib0h	780	1	15	15	CD
cord-021419-nypnib0h	780	2	kDa	kDa	NNS
cord-021419-nypnib0h	780	3	.	.	.
cord-021419-nypnib0h	781	1	The	the	DT
cord-021419-nypnib0h	781	2	molecular	molecular	JJ
cord-021419-nypnib0h	781	3	masses	masse	NNS
cord-021419-nypnib0h	781	4	of	of	IN
cord-021419-nypnib0h	781	5	conjugates	conjugate	NNS
cord-021419-nypnib0h	781	6	146	146	CD
cord-021419-nypnib0h	781	7	and	and	CC
cord-021419-nypnib0h	781	8	148	148	CD
cord-021419-nypnib0h	781	9	evaluated	evaluate	VBN
cord-021419-nypnib0h	781	10	by	by	IN
cord-021419-nypnib0h	781	11	gel	gel	NN
cord-021419-nypnib0h	781	12	chromatography	chromatography	NN
cord-021419-nypnib0h	781	13	on	on	IN
cord-021419-nypnib0h	781	14	a	a	DT
cord-021419-nypnib0h	781	15	Sephadex	Sephadex	NNP
cord-021419-nypnib0h	781	16	G-200	g-200	IN
cord-021419-nypnib0h	781	17	column	column	NN
cord-021419-nypnib0h	781	18	calibrated	calibrate	VBN
cord-021419-nypnib0h	781	19	with	with	IN
cord-021419-nypnib0h	781	20	pullulan	pullulan	JJ
cord-021419-nypnib0h	781	21	standards	standard	NNS
cord-021419-nypnib0h	781	22	are	be	VBP
cord-021419-nypnib0h	781	23	*	*	NFP
cord-021419-nypnib0h	781	24	95	95	CD
cord-021419-nypnib0h	781	25	and	and	CC
cord-021419-nypnib0h	781	26	*	*	NFP
cord-021419-nypnib0h	781	27	98	98	CD
cord-021419-nypnib0h	781	28	kDa	kDa	NNS
cord-021419-nypnib0h	781	29	,	,	,
cord-021419-nypnib0h	781	30	respectively	respectively	RB
cord-021419-nypnib0h	781	31	.	.	.
cord-021419-nypnib0h	782	1	The	the	DT
cord-021419-nypnib0h	782	2	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	782	3	activity	activity	NN
cord-021419-nypnib0h	782	4	of	of	IN
cord-021419-nypnib0h	782	5	the	the	DT
cord-021419-nypnib0h	782	6	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	782	7	conjugates	conjugate	NNS
cord-021419-nypnib0h	782	8	was	be	VBD
cord-021419-nypnib0h	782	9	tested	test	VBN
cord-021419-nypnib0h	782	10	in	in	IN
cord-021419-nypnib0h	782	11	three	three	CD
cord-021419-nypnib0h	782	12	tumour	tumour	NN
cord-021419-nypnib0h	782	13	cell	cell	NN
cord-021419-nypnib0h	782	14	lines	line	NNS
cord-021419-nypnib0h	782	15	:	:	:
cord-021419-nypnib0h	782	16	the	the	DT
cord-021419-nypnib0h	782	17	murine	murine	JJ
cord-021419-nypnib0h	782	18	melanoma	melanoma	NN
cord-021419-nypnib0h	782	19	cell	cell	NN
cord-021419-nypnib0h	782	20	line	line	NN
cord-021419-nypnib0h	782	21	B16-F1	B16-F1	NNP
cord-021419-nypnib0h	782	22	,	,	,
cord-021419-nypnib0h	782	23	the	the	DT
cord-021419-nypnib0h	782	24	breast	breast	NN
cord-021419-nypnib0h	782	25	cancer	cancer	NN
cord-021419-nypnib0h	782	26	cell	cell	NN
cord-021419-nypnib0h	782	27	line	line	NN
cord-021419-nypnib0h	782	28	MCF-7	MCF-7	NNP
cord-021419-nypnib0h	782	29	and	and	CC
cord-021419-nypnib0h	782	30	the	the	DT
cord-021419-nypnib0h	782	31	colon	colon	NN
cord-021419-nypnib0h	782	32	cancer	cancer	NN
cord-021419-nypnib0h	782	33	cell	cell	NN
cord-021419-nypnib0h	782	34	line	line	NN
cord-021419-nypnib0h	782	35	HT-29	HT-29	NNP
cord-021419-nypnib0h	782	36	(	(	-LRB-
cord-021419-nypnib0h	782	37	HTB-38	HTB-38	NNP
cord-021419-nypnib0h	782	38	)	)	-RRB-
cord-021419-nypnib0h	782	39	.	.	.
cord-021419-nypnib0h	783	1	96	96	CD
cord-021419-nypnib0h	784	1	The	the	DT
cord-021419-nypnib0h	784	2	IC	IC	NNP
cord-021419-nypnib0h	784	3	50	50	CD
cord-021419-nypnib0h	784	4	values	value	NNS
cord-021419-nypnib0h	784	5	for	for	IN
cord-021419-nypnib0h	784	6	conjugate	conjugate	NN
cord-021419-nypnib0h	784	7	146	146	CD
cord-021419-nypnib0h	784	8	(	(	-LRB-
cord-021419-nypnib0h	784	9	taking	take	VBG
cord-021419-nypnib0h	784	10	into	into	IN
cord-021419-nypnib0h	784	11	account	account	NN
cord-021419-nypnib0h	784	12	the	the	DT
cord-021419-nypnib0h	784	13	percentage	percentage	NN
cord-021419-nypnib0h	784	14	of	of	IN
cord-021419-nypnib0h	784	15	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	784	16	138a	138a	CD
cord-021419-nypnib0h	784	17	in	in	IN
cord-021419-nypnib0h	784	18	the	the	DT
cord-021419-nypnib0h	784	19	conjugate	conjugate	NN
cord-021419-nypnib0h	784	20	)	)	-RRB-
cord-021419-nypnib0h	784	21	are	be	VBP
cord-021419-nypnib0h	784	22	0.025	0.025	CD
cord-021419-nypnib0h	784	23	±	±	CD
cord-021419-nypnib0h	784	24	0.04	0.04	CD
cord-021419-nypnib0h	784	25	,	,	,
cord-021419-nypnib0h	784	26	0.15	0.15	CD
cord-021419-nypnib0h	784	27	±	±	CD
cord-021419-nypnib0h	784	28	0.22	0.22	CD
cord-021419-nypnib0h	784	29	and	and	CC
cord-021419-nypnib0h	784	30	0.65	0.65	CD
cord-021419-nypnib0h	784	31	±	±	CD
cord-021419-nypnib0h	784	32	1	1	CD
cord-021419-nypnib0h	784	33	mg	mg	NNP
cord-021419-nypnib0h	784	34	mL	mL	NNP
cord-021419-nypnib0h	784	35	71	71	CD
cord-021419-nypnib0h	784	36	,	,	,
cord-021419-nypnib0h	784	37	respectively	respectively	RB
cord-021419-nypnib0h	784	38	;	;	:
cord-021419-nypnib0h	784	39	for	for	IN
cord-021419-nypnib0h	784	40	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	784	41	138a	138a	CD
cord-021419-nypnib0h	784	42	,	,	,
cord-021419-nypnib0h	784	43	0.01	0.01	CD
cord-021419-nypnib0h	784	44	±	±	CD
cord-021419-nypnib0h	784	45	0.02	0.02	CD
cord-021419-nypnib0h	784	46	,	,	,
cord-021419-nypnib0h	784	47	0.08	0.08	CD
cord-021419-nypnib0h	784	48	±	±	CD
cord-021419-nypnib0h	784	49	0.12	0.12	CD
cord-021419-nypnib0h	784	50	and	and	CC
cord-021419-nypnib0h	784	51	0.2	0.2	CD
cord-021419-nypnib0h	784	52	±	±	CD
cord-021419-nypnib0h	784	53	0.3	0.3	CD
cord-021419-nypnib0h	784	54	mg	mg	NNP
cord-021419-nypnib0h	784	55	mL	mL	NNP
cord-021419-nypnib0h	784	56	71	71	CD
cord-021419-nypnib0h	784	57	.	.	.
cord-021419-nypnib0h	785	1	Despite	despite	IN
cord-021419-nypnib0h	785	2	the	the	DT
cord-021419-nypnib0h	785	3	fact	fact	NN
cord-021419-nypnib0h	785	4	that	that	IN
cord-021419-nypnib0h	785	5	the	the	DT
cord-021419-nypnib0h	785	6	cytotoxicity	cytotoxicity	NN
cord-021419-nypnib0h	785	7	of	of	IN
cord-021419-nypnib0h	785	8	conjugate	conjugate	NNP
cord-021419-nypnib0h	785	9	146	146	CD
cord-021419-nypnib0h	785	10	is	be	VBZ
cord-021419-nypnib0h	785	11	*	*	NFP
cord-021419-nypnib0h	785	12	1	1	CD
cord-021419-nypnib0h	785	13	±	±	CD
cord-021419-nypnib0h	785	14	2	2	CD
cord-021419-nypnib0h	785	15	orders	order	NNS
cord-021419-nypnib0h	785	16	of	of	IN
cord-021419-nypnib0h	785	17	magnitude	magnitude	NN
cord-021419-nypnib0h	785	18	lower	lower	RBR
cord-021419-nypnib0h	785	19	(	(	-LRB-
cord-021419-nypnib0h	785	20	data	datum	NNS
cord-021419-nypnib0h	785	21	were	be	VBD
cord-021419-nypnib0h	785	22	not	not	RB
cord-021419-nypnib0h	785	23	reported	report	VBN
cord-021419-nypnib0h	785	24	)	)	-RRB-
cord-021419-nypnib0h	785	25	than	than	IN
cord-021419-nypnib0h	785	26	that	that	DT
cord-021419-nypnib0h	785	27	of	of	IN
cord-021419-nypnib0h	785	28	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	785	29	(	(	-LRB-
cord-021419-nypnib0h	785	30	138a	138a	CD
cord-021419-nypnib0h	785	31	)	)	-RRB-
cord-021419-nypnib0h	785	32	,	,	,
cord-021419-nypnib0h	785	33	these	these	DT
cord-021419-nypnib0h	785	34	results	result	NNS
cord-021419-nypnib0h	785	35	indicate	indicate	VBP
cord-021419-nypnib0h	785	36	that	that	IN
cord-021419-nypnib0h	785	37	conjugate	conjugate	VBN
cord-021419-nypnib0h	785	38	146	146	CD
cord-021419-nypnib0h	785	39	is	be	VBZ
cord-021419-nypnib0h	785	40	an	an	DT
cord-021419-nypnib0h	785	41	active	active	JJ
cord-021419-nypnib0h	785	42	depot	depot	NN
cord-021419-nypnib0h	785	43	form	form	NN
cord-021419-nypnib0h	785	44	of	of	IN
cord-021419-nypnib0h	785	45	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	785	46	(	(	-LRB-
cord-021419-nypnib0h	785	47	138a	138a	CD
cord-021419-nypnib0h	785	48	)	)	-RRB-
cord-021419-nypnib0h	785	49	.	.	.
cord-021419-nypnib0h	786	1	The	the	DT
cord-021419-nypnib0h	786	2	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	786	3	activity	activity	NN
cord-021419-nypnib0h	786	4	of	of	IN
cord-021419-nypnib0h	786	5	the	the	DT
cord-021419-nypnib0h	786	6	3	3	CD
cord-021419-nypnib0h	786	7	H	h	NN
cord-021419-nypnib0h	786	8	-N	-n	NN
cord-021419-nypnib0h	786	9	-	-	HYPH
cord-021419-nypnib0h	786	10	L	l	NN
cord-021419-nypnib0h	786	11	-	-	HYPH
cord-021419-nypnib0h	786	12	lysyldoxorubicin	lysyldoxorubicin	NNS
cord-021419-nypnib0h	786	13	±	±	NNP
cord-021419-nypnib0h	786	14	DAVANAT	DAVANAT	NNP
cord-021419-nypnib0h	786	15	conjugate	conjugate	NN
cord-021419-nypnib0h	786	16	(	(	-LRB-
cord-021419-nypnib0h	786	17	148	148	CD
cord-021419-nypnib0h	786	18	)	)	-RRB-
cord-021419-nypnib0h	786	19	(	(	-LRB-
cord-021419-nypnib0h	786	20	IC	IC	NNP
cord-021419-nypnib0h	786	21	50	50	CD
cord-021419-nypnib0h	786	22	>	>	SYM
cord-021419-nypnib0h	786	23	50	50	CD
cord-021419-nypnib0h	786	24	mg	mg	NN
cord-021419-nypnib0h	786	25	mL	mL	NNP
cord-021419-nypnib0h	786	26	71	71	CD
cord-021419-nypnib0h	786	27	)	)	-RRB-
cord-021419-nypnib0h	786	28	against	against	IN
cord-021419-nypnib0h	786	29	these	these	DT
cord-021419-nypnib0h	786	30	tumour	tumour	NN
cord-021419-nypnib0h	786	31	cell	cell	NN
cord-021419-nypnib0h	786	32	lines	line	NNS
cord-021419-nypnib0h	786	33	is	be	VBZ
cord-021419-nypnib0h	786	34	much	much	RB
cord-021419-nypnib0h	786	35	lower	low	JJR
cord-021419-nypnib0h	786	36	compared	compare	VBN
cord-021419-nypnib0h	786	37	to	to	IN
cord-021419-nypnib0h	786	38	cytotoxicity	cytotoxicity	NN
cord-021419-nypnib0h	786	39	of	of	IN
cord-021419-nypnib0h	786	40	conjugate	conjugate	NN
cord-021419-nypnib0h	786	41	146	146	CD
cord-021419-nypnib0h	786	42	.	.	.
cord-021419-nypnib0h	787	1	This	this	DT
cord-021419-nypnib0h	787	2	can	can	MD
cord-021419-nypnib0h	787	3	be	be	VB
cord-021419-nypnib0h	787	4	due	due	JJ
cord-021419-nypnib0h	787	5	to	to	IN
cord-021419-nypnib0h	787	6	the	the	DT
cord-021419-nypnib0h	787	7	fact	fact	NN
cord-021419-nypnib0h	787	8	that	that	IN
cord-021419-nypnib0h	787	9	the	the	DT
cord-021419-nypnib0h	787	10	imine	imine	NN
cord-021419-nypnib0h	787	11	bonds	bond	NNS
cord-021419-nypnib0h	787	12	in	in	IN
cord-021419-nypnib0h	787	13	the	the	DT
cord-021419-nypnib0h	787	14	3	3	CD
cord-021419-nypnib0h	787	15	H	h	NN
cord-021419-nypnib0h	787	16	-N	-n	NN
cord-021419-nypnib0h	787	17	-	-	HYPH
cord-021419-nypnib0h	787	18	L	l	NN
cord-021419-nypnib0h	787	19	-	-	HYPH
cord-021419-nypnib0h	787	20	lysyldoxorubicin	lysyldoxorubicin	NNS
cord-021419-nypnib0h	787	21	±	±	NNP
cord-021419-nypnib0h	787	22	DA	DA	NNP
cord-021419-nypnib0h	787	23	-	-	HYPH
cord-021419-nypnib0h	787	24	VANAT	VANAT	NNP
cord-021419-nypnib0h	787	25	conjugate	conjugate	NN
cord-021419-nypnib0h	787	26	(	(	-LRB-
cord-021419-nypnib0h	787	27	148	148	CD
cord-021419-nypnib0h	787	28	)	)	-RRB-
cord-021419-nypnib0h	787	29	are	be	VBP
cord-021419-nypnib0h	787	30	more	more	RBR
cord-021419-nypnib0h	787	31	stable	stable	JJ
cord-021419-nypnib0h	787	32	than	than	IN
cord-021419-nypnib0h	787	33	those	those	DT
cord-021419-nypnib0h	787	34	in	in	IN
cord-021419-nypnib0h	787	35	conjugate	conjugate	NN
cord-021419-nypnib0h	787	36	146	146	CD
cord-021419-nypnib0h	787	37	.	.	.
cord-021419-nypnib0h	788	1	It	-PRON-	PRP
cord-021419-nypnib0h	788	2	should	should	MD
cord-021419-nypnib0h	788	3	be	be	VB
cord-021419-nypnib0h	788	4	noted	note	VBN
cord-021419-nypnib0h	788	5	that	that	IN
cord-021419-nypnib0h	788	6	3	3	CD
cord-021419-nypnib0h	788	7	H	h	NN
cord-021419-nypnib0h	788	8	-N	-n	NN
cord-021419-nypnib0h	788	9	-	-	HYPH
cord-021419-nypnib0h	788	10	L	l	NN
cord-021419-nypnib0h	788	11	-	-	HYPH
cord-021419-nypnib0h	788	12	lysyldoxorubicin	lysyldoxorubicin	NNS
cord-021419-nypnib0h	788	13	is	be	VBZ
cord-021419-nypnib0h	788	14	not	not	RB
cord-021419-nypnib0h	788	15	released	release	VBN
cord-021419-nypnib0h	788	16	in	in	RP
cord-021419-nypnib0h	788	17	in	in	FW
cord-021419-nypnib0h	788	18	vitro	vitro	FW
cord-021419-nypnib0h	788	19	assays	assay	NNS
cord-021419-nypnib0h	788	20	.	.	.
cord-021419-nypnib0h	789	1	Therefore	therefore	RB
cord-021419-nypnib0h	789	2	,	,	,
cord-021419-nypnib0h	789	3	a	a	DT
cord-021419-nypnib0h	789	4	biological	biological	JJ
cord-021419-nypnib0h	789	5	model	model	NN
cord-021419-nypnib0h	789	6	,	,	,
cord-021419-nypnib0h	789	7	which	which	WDT
cord-021419-nypnib0h	789	8	would	would	MD
cord-021419-nypnib0h	789	9	provide	provide	VB
cord-021419-nypnib0h	789	10	release	release	NN
cord-021419-nypnib0h	789	11	of	of	IN
cord-021419-nypnib0h	789	12	147	147	CD
cord-021419-nypnib0h	789	13	,	,	,
cord-021419-nypnib0h	789	14	is	be	VBZ
cord-021419-nypnib0h	789	15	apparently	apparently	RB
cord-021419-nypnib0h	789	16	required	require	VBN
cord-021419-nypnib0h	789	17	to	to	TO
cord-021419-nypnib0h	789	18	evaluate	evaluate	VB
cord-021419-nypnib0h	789	19	the	the	DT
cord-021419-nypnib0h	789	20	therapeutic	therapeutic	JJ
cord-021419-nypnib0h	789	21	potential	potential	NN
cord-021419-nypnib0h	789	22	of	of	IN
cord-021419-nypnib0h	789	23	conjugate	conjugate	NN
cord-021419-nypnib0h	789	24	148	148	CD
cord-021419-nypnib0h	789	25	.	.	.
cord-021419-nypnib0h	790	1	Based	base	VBN
cord-021419-nypnib0h	790	2	on	on	IN
cord-021419-nypnib0h	790	3	these	these	DT
cord-021419-nypnib0h	790	4	studies	study	NNS
cord-021419-nypnib0h	790	5	,	,	,
cord-021419-nypnib0h	790	6	a	a	DT
cord-021419-nypnib0h	790	7	method	method	NN
cord-021419-nypnib0h	790	8	was	be	VBD
cord-021419-nypnib0h	790	9	developed	develop	VBN
cord-021419-nypnib0h	790	10	for	for	IN
cord-021419-nypnib0h	790	11	the	the	DT
cord-021419-nypnib0h	790	12	introduction	introduction	NN
cord-021419-nypnib0h	790	13	of	of	IN
cord-021419-nypnib0h	790	14	polyhydroxylated	polyhydroxylated	JJ
cord-021419-nypnib0h	790	15	substituents	substituent	NNS
cord-021419-nypnib0h	790	16	of	of	IN
cord-021419-nypnib0h	790	17	different	different	JJ
cord-021419-nypnib0h	790	18	types	type	NNS
cord-021419-nypnib0h	790	19	and	and	CC
cord-021419-nypnib0h	790	20	different	different	JJ
cord-021419-nypnib0h	790	21	length	length	NN
cord-021419-nypnib0h	790	22	into	into	IN
cord-021419-nypnib0h	790	23	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	790	24	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	790	25	,	,	,
cord-021419-nypnib0h	790	26	which	which	WDT
cord-021419-nypnib0h	790	27	was	be	VBD
cord-021419-nypnib0h	790	28	used	use	VBN
cord-021419-nypnib0h	790	29	to	to	TO
cord-021419-nypnib0h	790	30	synthesize	synthesize	VB
cord-021419-nypnib0h	790	31	a	a	DT
cord-021419-nypnib0h	790	32	series	series	NN
cord-021419-nypnib0h	790	33	of	of	IN
cord-021419-nypnib0h	790	34	new	new	JJ
cord-021419-nypnib0h	790	35	hydrophilic	hydrophilic	JJ
cord-021419-nypnib0h	790	36	3	3	CD
cord-021419-nypnib0h	790	37	H	h	NN
cord-021419-nypnib0h	790	38	-N	-n	NN
cord-021419-nypnib0h	790	39	-	-	HYPH
cord-021419-nypnib0h	790	40	alkyl	alkyl	JJ
cord-021419-nypnib0h	790	41	derivatives	derivative	NNS
cord-021419-nypnib0h	790	42	of	of	IN
cord-021419-nypnib0h	790	43	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	790	44	and	and	CC
cord-021419-nypnib0h	790	45	14-hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	790	46	,	,	,
cord-021419-nypnib0h	790	47	including	include	VBG
cord-021419-nypnib0h	790	48	those	those	DT
cord-021419-nypnib0h	790	49	containing	contain	VBG
cord-021419-nypnib0h	790	50	mono	mono	NN
cord-021419-nypnib0h	790	51	-	-	HYPH
cord-021419-nypnib0h	790	52	and	and	CC
cord-021419-nypnib0h	790	53	disaccharide	disaccharide	NN
cord-021419-nypnib0h	790	54	residues	residue	NNS
cord-021419-nypnib0h	790	55	.	.	.
cord-021419-nypnib0h	791	1	92	92	CD
cord-021419-nypnib0h	791	2	,	,	,
cord-021419-nypnib0h	791	3	93	93	CD
cord-021419-nypnib0h	792	1	This	this	DT
cord-021419-nypnib0h	792	2	modification	modification	NN
cord-021419-nypnib0h	792	3	was	be	VBD
cord-021419-nypnib0h	792	4	found	find	VBN
cord-021419-nypnib0h	792	5	to	to	TO
cord-021419-nypnib0h	792	6	enhance	enhance	VB
cord-021419-nypnib0h	792	7	the	the	DT
cord-021419-nypnib0h	792	8	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	792	9	activity	activity	NN
cord-021419-nypnib0h	792	10	of	of	IN
cord-021419-nypnib0h	792	11	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	792	12	against	against	IN
cord-021419-nypnib0h	792	13	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	792	14	I	-PRON-	PRP
cord-021419-nypnib0h	792	15	with	with	IN
cord-021419-nypnib0h	792	16	retention	retention	NN
cord-021419-nypnib0h	792	17	of	of	IN
cord-021419-nypnib0h	792	18	antitumour	antitumour	JJ
cord-021419-nypnib0h	792	19	activity	activity	NN
cord-021419-nypnib0h	792	20	of	of	IN
cord-021419-nypnib0h	792	21	the	the	DT
cord-021419-nypnib0h	792	22	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	792	23	.	.	.
cord-021419-nypnib0h	793	1	The	the	DT
cord-021419-nypnib0h	793	2	new	new	JJ
cord-021419-nypnib0h	793	3	14-hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	793	4	derivatives	derivative	NNS
cord-021419-nypnib0h	793	5	,	,	,
cord-021419-nypnib0h	793	6	unlike	unlike	IN
cord-021419-nypnib0h	793	7	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	793	8	derivatives	derivative	NNS
cord-021419-nypnib0h	793	9	,	,	,
cord-021419-nypnib0h	793	10	were	be	VBD
cord-021419-nypnib0h	793	11	shown	show	VBN
cord-021419-nypnib0h	793	12	to	to	TO
cord-021419-nypnib0h	793	13	suppress	suppress	VB
cord-021419-nypnib0h	793	14	the	the	DT
cord-021419-nypnib0h	793	15	tumour	tumour	NN
cord-021419-nypnib0h	793	16	cell	cell	NN
cord-021419-nypnib0h	793	17	growth	growth	NN
cord-021419-nypnib0h	793	18	insensitive	insensitive	JJ
cord-021419-nypnib0h	793	19	to	to	IN
cord-021419-nypnib0h	793	20	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	793	21	.	.	.
cord-021419-nypnib0h	794	1	93	93	CD
cord-021419-nypnib0h	795	1	A	a	DT
cord-021419-nypnib0h	795	2	new	new	JJ
cord-021419-nypnib0h	795	3	water	water	NN
cord-021419-nypnib0h	795	4	-	-	HYPH
cord-021419-nypnib0h	795	5	soluble	soluble	JJ
cord-021419-nypnib0h	795	6	depot	depot	NN
cord-021419-nypnib0h	795	7	form	form	NN
cord-021419-nypnib0h	795	8	of	of	IN
cord-021419-nypnib0h	795	9	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	795	10	Ð	Ð	NNP
cord-021419-nypnib0h	795	11	a	a	DT
cord-021419-nypnib0h	795	12	conjugate	conjugate	NN
cord-021419-nypnib0h	795	13	with	with	IN
cord-021419-nypnib0h	795	14	the	the	DT
cord-021419-nypnib0h	795	15	highmolecular	highmolecular	NNP
cord-021419-nypnib0h	795	16	-	-	HYPH
cord-021419-nypnib0h	795	17	mass	mass	NNP
cord-021419-nypnib0h	795	18	polysaccharide	polysaccharide	NN
cord-021419-nypnib0h	795	19	galactomannan	galactomannan	NNP
cord-021419-nypnib0h	795	20	DAVA	DAVA	NNP
cord-021419-nypnib0h	795	21	-	-	HYPH
cord-021419-nypnib0h	795	22	NAT	NAT	NNP
cord-021419-nypnib0h	795	23	Ð	Ð	NNP
cord-021419-nypnib0h	795	24	was	be	VBD
cord-021419-nypnib0h	795	25	prepared	prepared	JJ
cord-021419-nypnib0h	795	26	.	.	.
cord-021419-nypnib0h	796	1	94	94	CD
cord-021419-nypnib0h	796	2	,	,	,
cord-021419-nypnib0h	796	3	95	95	CD
cord-021419-nypnib0h	797	1	This	this	DT
cord-021419-nypnib0h	797	2	depot	depot	NN
cord-021419-nypnib0h	797	3	form	form	NN
cord-021419-nypnib0h	797	4	exhibits	exhibit	VBZ
cord-021419-nypnib0h	797	5	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	797	6	activity	activity	NN
cord-021419-nypnib0h	797	7	against	against	IN
cord-021419-nypnib0h	797	8	the	the	DT
cord-021419-nypnib0h	797	9	above	above	RB
cord-021419-nypnib0h	797	10	-	-	HYPH
cord-021419-nypnib0h	797	11	mentioned	mention	VBN
cord-021419-nypnib0h	797	12	three	three	CD
cord-021419-nypnib0h	797	13	tumour	tumour	NN
cord-021419-nypnib0h	797	14	cell	cell	NN
cord-021419-nypnib0h	797	15	lines	line	NNS
cord-021419-nypnib0h	797	16	.	.	.
cord-021419-nypnib0h	798	1	91	91	CD
cord-021419-nypnib0h	798	2	 	 	_SP
cord-021419-nypnib0h	799	1	The	the	DT
cord-021419-nypnib0h	799	2	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	799	3	heliomycin	heliomycin	NNS
cord-021419-nypnib0h	799	4	(	(	-LRB-
cord-021419-nypnib0h	799	5	resistomycin	resistomycin	NNS
cord-021419-nypnib0h	799	6	,	,	,
cord-021419-nypnib0h	799	7	3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H	3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1h	CD
cord-021419-nypnib0h	799	8	-	-	:
cord-021419-nypnib0h	799	9	benzo[cd	benzo[cd	NNP
cord-021419-nypnib0h	799	10	]	]	-RRB-
cord-021419-nypnib0h	799	11	pyrene-2,6-dione	pyrene-2,6-dione	NNP
cord-021419-nypnib0h	799	12	)	)	-RRB-
cord-021419-nypnib0h	799	13	(	(	-LRB-
cord-021419-nypnib0h	799	14	149	149	CD
cord-021419-nypnib0h	799	15	)	)	-RRB-
cord-021419-nypnib0h	799	16	with	with	IN
cord-021419-nypnib0h	799	17	a	a	DT
cord-021419-nypnib0h	799	18	broad	broad	JJ
cord-021419-nypnib0h	799	19	spectrum	spectrum	NN
cord-021419-nypnib0h	799	20	of	of	IN
cord-021419-nypnib0h	799	21	biological	biological	JJ
cord-021419-nypnib0h	799	22	activity	activity	NN
cord-021419-nypnib0h	799	23	(	(	-LRB-
cord-021419-nypnib0h	799	24	Scheme	scheme	NN
cord-021419-nypnib0h	799	25	42	42	CD
cord-021419-nypnib0h	799	26	)	)	-RRB-
cord-021419-nypnib0h	799	27	was	be	VBD
cord-021419-nypnib0h	799	28	discovered	discover	VBN
cord-021419-nypnib0h	799	29	in	in	IN
cord-021419-nypnib0h	799	30	the	the	DT
cord-021419-nypnib0h	799	31	Gause	Gause	NNP
cord-021419-nypnib0h	799	32	Institute	Institute	NNP
cord-021419-nypnib0h	799	33	of	of	IN
cord-021419-nypnib0h	799	34	New	New	NNP
cord-021419-nypnib0h	799	35	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	799	36	.	.	.
cord-021419-nypnib0h	800	1	6	6	CD
cord-021419-nypnib0h	801	1	First	first	RB
cord-021419-nypnib0h	801	2	of	of	IN
cord-021419-nypnib0h	801	3	all	all	DT
cord-021419-nypnib0h	801	4	,	,	,
cord-021419-nypnib0h	801	5	this	this	DT
cord-021419-nypnib0h	801	6	antibiotic	antibiotic	NN
cord-021419-nypnib0h	801	7	is	be	VBZ
cord-021419-nypnib0h	801	8	highly	highly	RB
cord-021419-nypnib0h	801	9	effective	effective	JJ
cord-021419-nypnib0h	801	10	against	against	IN
cord-021419-nypnib0h	801	11	Grampositive	Grampositive	NNP
cord-021419-nypnib0h	801	12	and	and	CC
cord-021419-nypnib0h	801	13	some	some	DT
cord-021419-nypnib0h	801	14	Gram	gram	NN
cord-021419-nypnib0h	801	15	-	-	HYPH
cord-021419-nypnib0h	801	16	negative	negative	JJ
cord-021419-nypnib0h	801	17	microorganisms	microorganism	NNS
cord-021419-nypnib0h	801	18	,	,	,
cord-021419-nypnib0h	801	19	including	include	VBG
cord-021419-nypnib0h	801	20	drug	drug	NN
cord-021419-nypnib0h	801	21	-	-	HYPH
cord-021419-nypnib0h	801	22	resistant	resistant	JJ
cord-021419-nypnib0h	801	23	strains	strain	NNS
cord-021419-nypnib0h	801	24	.	.	.
cord-021419-nypnib0h	802	1	More	more	RBR
cord-021419-nypnib0h	802	2	recently	recently	RB
cord-021419-nypnib0h	802	3	,	,	,
cord-021419-nypnib0h	802	4	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	802	5	was	be	VBD
cord-021419-nypnib0h	802	6	found	find	VBN
cord-021419-nypnib0h	802	7	to	to	TO
cord-021419-nypnib0h	802	8	exhibit	exhibit	VB
cord-021419-nypnib0h	802	9	antifungal	antifungal	NN
cord-021419-nypnib0h	802	10	97	97	CD
cord-021419-nypnib0h	802	11	and	and	CC
cord-021419-nypnib0h	802	12	antiviral	antiviral	JJ
cord-021419-nypnib0h	802	13	(	(	-LRB-
cord-021419-nypnib0h	802	14	anti	anti	JJ
cord-021419-nypnib0h	802	15	-	-	JJ
cord-021419-nypnib0h	802	16	HIV	HIV	NNP
cord-021419-nypnib0h	802	17	)	)	-RRB-
cord-021419-nypnib0h	802	18	activity	activity	NN
cord-021419-nypnib0h	802	19	.	.	.
cord-021419-nypnib0h	803	1	98	98	CD
cord-021419-nypnib0h	804	1	Besides	besides	RB
cord-021419-nypnib0h	804	2	,	,	,
cord-021419-nypnib0h	804	3	compound	compound	VB
cord-021419-nypnib0h	804	4	149	149	CD
cord-021419-nypnib0h	804	5	can	can	MD
cord-021419-nypnib0h	804	6	block	block	VB
cord-021419-nypnib0h	804	7	proliferation	proliferation	NN
cord-021419-nypnib0h	804	8	of	of	IN
cord-021419-nypnib0h	804	9	some	some	DT
cord-021419-nypnib0h	804	10	tumour	tumour	NN
cord-021419-nypnib0h	804	11	cells	cell	NNS
cord-021419-nypnib0h	804	12	in	in	IN
cord-021419-nypnib0h	804	13	in	in	IN
cord-021419-nypnib0h	804	14	vitro	vitro	FW
cord-021419-nypnib0h	804	15	assays	assay	NNS
cord-021419-nypnib0h	804	16	.	.	.
cord-021419-nypnib0h	805	1	99	99	CD
cord-021419-nypnib0h	806	1	In	in	IN
cord-021419-nypnib0h	806	2	the	the	DT
cord-021419-nypnib0h	806	3	Soviet	Soviet	NNP
cord-021419-nypnib0h	806	4	Union	Union	NNP
cord-021419-nypnib0h	806	5	,	,	,
cord-021419-nypnib0h	806	6	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	806	7	(	(	-LRB-
cord-021419-nypnib0h	806	8	149	149	CD
cord-021419-nypnib0h	806	9	)	)	-RRB-
cord-021419-nypnib0h	806	10	was	be	VBD
cord-021419-nypnib0h	806	11	produced	produce	VBN
cord-021419-nypnib0h	806	12	on	on	IN
cord-021419-nypnib0h	806	13	a	a	DT
cord-021419-nypnib0h	806	14	commercial	commercial	JJ
cord-021419-nypnib0h	806	15	scale	scale	NN
cord-021419-nypnib0h	806	16	and	and	CC
cord-021419-nypnib0h	806	17	was	be	VBD
cord-021419-nypnib0h	806	18	used	use	VBN
cord-021419-nypnib0h	806	19	as	as	IN
cord-021419-nypnib0h	806	20	a	a	DT
cord-021419-nypnib0h	806	21	gel	gel	NN
cord-021419-nypnib0h	806	22	for	for	IN
cord-021419-nypnib0h	806	23	topical	topical	JJ
cord-021419-nypnib0h	806	24	treatment	treatment	NN
cord-021419-nypnib0h	806	25	of	of	IN
cord-021419-nypnib0h	806	26	skin	skin	NN
cord-021419-nypnib0h	806	27	infections	infection	NNS
cord-021419-nypnib0h	806	28	and	and	CC
cord-021419-nypnib0h	806	29	healing	healing	NN
cord-021419-nypnib0h	806	30	of	of	IN
cord-021419-nypnib0h	806	31	burn	burn	NN
cord-021419-nypnib0h	806	32	wounds	wound	NNS
cord-021419-nypnib0h	806	33	.	.	.
cord-021419-nypnib0h	807	1	The	the	DT
cord-021419-nypnib0h	807	2	chemical	chemical	JJ
cord-021419-nypnib0h	807	3	modification	modification	NN
cord-021419-nypnib0h	807	4	of	of	IN
cord-021419-nypnib0h	807	5	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	807	6	is	be	VBZ
cord-021419-nypnib0h	807	7	poorly	poorly	RB
cord-021419-nypnib0h	807	8	known	know	VBN
cord-021419-nypnib0h	807	9	.	.	.
cord-021419-nypnib0h	808	1	Hence	hence	RB
cord-021419-nypnib0h	808	2	,	,	,
cord-021419-nypnib0h	808	3	structure	structure	NN
cord-021419-nypnib0h	808	4	±	±	CD
cord-021419-nypnib0h	808	5	activity	activity	NN
cord-021419-nypnib0h	808	6	relationship	relationship	NN
cord-021419-nypnib0h	808	7	studies	study	NNS
cord-021419-nypnib0h	808	8	require	require	VBP
cord-021419-nypnib0h	808	9	the	the	DT
cord-021419-nypnib0h	808	10	development	development	NN
cord-021419-nypnib0h	808	11	of	of	IN
cord-021419-nypnib0h	808	12	method	method	NN
cord-021419-nypnib0h	808	13	for	for	IN
cord-021419-nypnib0h	808	14	the	the	DT
cord-021419-nypnib0h	808	15	synthesis	synthesis	NN
cord-021419-nypnib0h	808	16	of	of	IN
cord-021419-nypnib0h	808	17	new	new	JJ
cord-021419-nypnib0h	808	18	semi	semi	JJ
cord-021419-nypnib0h	808	19	-	-	JJ
cord-021419-nypnib0h	808	20	synthetic	synthetic	JJ
cord-021419-nypnib0h	808	21	derivatives	derivative	NNS
cord-021419-nypnib0h	808	22	and	and	CC
cord-021419-nypnib0h	808	23	evaluation	evaluation	NN
cord-021419-nypnib0h	808	24	of	of	IN
cord-021419-nypnib0h	808	25	their	-PRON-	PRP$
cord-021419-nypnib0h	808	26	biological	biological	JJ
cord-021419-nypnib0h	808	27	properties	property	NNS
cord-021419-nypnib0h	808	28	.	.	.
cord-021419-nypnib0h	809	1	The	the	DT
cord-021419-nypnib0h	809	2	main	main	JJ
cord-021419-nypnib0h	809	3	goal	goal	NN
cord-021419-nypnib0h	809	4	is	be	VBZ
cord-021419-nypnib0h	809	5	to	to	TO
cord-021419-nypnib0h	809	6	prepare	prepare	VB
cord-021419-nypnib0h	809	7	series	series	NN
cord-021419-nypnib0h	809	8	of	of	IN
cord-021419-nypnib0h	809	9	derivatives	derivative	NNS
cord-021419-nypnib0h	809	10	with	with	IN
cord-021419-nypnib0h	809	11	improved	improved	JJ
cord-021419-nypnib0h	809	12	water	water	NN
cord-021419-nypnib0h	809	13	solubility	solubility	NN
cord-021419-nypnib0h	809	14	in	in	IN
cord-021419-nypnib0h	809	15	order	order	NN
cord-021419-nypnib0h	809	16	to	to	TO
cord-021419-nypnib0h	809	17	expand	expand	VB
cord-021419-nypnib0h	809	18	their	-PRON-	PRP$
cord-021419-nypnib0h	809	19	practical	practical	JJ
cord-021419-nypnib0h	809	20	application	application	NN
cord-021419-nypnib0h	809	21	.	.	.
cord-021419-nypnib0h	810	1	A	a	DT
cord-021419-nypnib0h	810	2	method	method	NN
cord-021419-nypnib0h	810	3	was	be	VBD
cord-021419-nypnib0h	810	4	developed	develop	VBN
cord-021419-nypnib0h	810	5	for	for	IN
cord-021419-nypnib0h	810	6	the	the	DT
cord-021419-nypnib0h	810	7	synthesis	synthesis	NN
cord-021419-nypnib0h	810	8	of	of	IN
cord-021419-nypnib0h	810	9	aminomethyl	aminomethyl	NNP
cord-021419-nypnib0h	810	10	derivatives	derivative	VBZ
cord-021419-nypnib0h	810	11	149	149	CD
cord-021419-nypnib0h	810	12	at	at	IN
cord-021419-nypnib0h	810	13	the	the	DT
cord-021419-nypnib0h	810	14	4	4	CD
cord-021419-nypnib0h	810	15	position	position	NN
cord-021419-nypnib0h	810	16	of	of	IN
cord-021419-nypnib0h	810	17	compounds	compound	NNS
cord-021419-nypnib0h	810	18	150	150	CD
cord-021419-nypnib0h	810	19	(	(	-LRB-
cord-021419-nypnib0h	810	20	where	where	WRB
cord-021419-nypnib0h	810	21	X	x	NN
cord-021419-nypnib0h	810	22	is	be	VBZ
cord-021419-nypnib0h	810	23	an	an	DT
cord-021419-nypnib0h	810	24	amine	amine	NN
cord-021419-nypnib0h	810	25	moiety	moiety	NN
cord-021419-nypnib0h	810	26	or	or	CC
cord-021419-nypnib0h	810	27	a	a	DT
cord-021419-nypnib0h	810	28	nitrogen	nitrogen	NN
cord-021419-nypnib0h	810	29	-	-	HYPH
cord-021419-nypnib0h	810	30	containing	contain	VBG
cord-021419-nypnib0h	810	31	heterocycle	heterocycle	NNP
cord-021419-nypnib0h	810	32	)	)	-RRB-
cord-021419-nypnib0h	810	33	.	.	.
cord-021419-nypnib0h	811	1	Typical	typical	JJ
cord-021419-nypnib0h	811	2	synthetic	synthetic	JJ
cord-021419-nypnib0h	811	3	procedures	procedure	NNS
cord-021419-nypnib0h	811	4	are	be	VBP
cord-021419-nypnib0h	811	5	presented	present	VBN
cord-021419-nypnib0h	811	6	in	in	IN
cord-021419-nypnib0h	811	7	relation	relation	NN
cord-021419-nypnib0h	811	8	to	to	IN
cord-021419-nypnib0h	811	9	compounds	compound	NNS
cord-021419-nypnib0h	811	10	150a	150a	.
cord-021419-nypnib0h	811	11	±	±	NNP
cord-021419-nypnib0h	812	1	c	c	LS
cord-021419-nypnib0h	812	2	(	(	-LRB-
cord-021419-nypnib0h	812	3	see	see	VB
cord-021419-nypnib0h	812	4	Scheme	Scheme	NNP
cord-021419-nypnib0h	812	5	42	42	CD
cord-021419-nypnib0h	812	6	)	)	-RRB-
cord-021419-nypnib0h	812	7	.	.	.
cord-021419-nypnib0h	813	1	100	100	CD
cord-021419-nypnib0h	813	2	,	,	,
cord-021419-nypnib0h	813	3	101	101	CD
cord-021419-nypnib0h	814	1	The	the	DT
cord-021419-nypnib0h	814	2	Mannich	Mannich	NNP
cord-021419-nypnib0h	814	3	aminomethylation	aminomethylation	NN
cord-021419-nypnib0h	814	4	of	of	IN
cord-021419-nypnib0h	814	5	compound	compound	NN
cord-021419-nypnib0h	814	6	149	149	CD
cord-021419-nypnib0h	814	7	can	can	MD
cord-021419-nypnib0h	814	8	be	be	VB
cord-021419-nypnib0h	814	9	performed	perform	VBN
cord-021419-nypnib0h	814	10	using	use	VBG
cord-021419-nypnib0h	814	11	amines	amine	NNS
cord-021419-nypnib0h	814	12	and	and	CC
cord-021419-nypnib0h	814	13	formaldehyde	formaldehyde	NN
cord-021419-nypnib0h	814	14	in	in	IN
cord-021419-nypnib0h	814	15	DMF	DMF	NNP
cord-021419-nypnib0h	814	16	(	(	-LRB-
cord-021419-nypnib0h	814	17	see	see	VB
cord-021419-nypnib0h	814	18	Scheme	scheme	NN
cord-021419-nypnib0h	814	19	42	42	CD
cord-021419-nypnib0h	814	20	b	b	LS
cord-021419-nypnib0h	814	21	)	)	-RRB-
cord-021419-nypnib0h	814	22	.	.	.
cord-021419-nypnib0h	815	1	An	an	DT
cord-021419-nypnib0h	815	2	alternative	alternative	JJ
cord-021419-nypnib0h	815	3	procedure	procedure	NN
cord-021419-nypnib0h	815	4	for	for	IN
cord-021419-nypnib0h	815	5	the	the	DT
cord-021419-nypnib0h	815	6	synthesis	synthesis	NN
cord-021419-nypnib0h	815	7	of	of	IN
cord-021419-nypnib0h	815	8	derivatives	derivative	NNS
cord-021419-nypnib0h	815	9	150	150	CD
cord-021419-nypnib0h	815	10	is	be	VBZ
cord-021419-nypnib0h	815	11	based	base	VBN
cord-021419-nypnib0h	815	12	on	on	IN
cord-021419-nypnib0h	815	13	the	the	DT
cord-021419-nypnib0h	815	14	use	use	NN
cord-021419-nypnib0h	815	15	of	of	IN
cord-021419-nypnib0h	815	16	pre	pre	JJ
cord-021419-nypnib0h	815	17	-	-	JJ
cord-021419-nypnib0h	815	18	prepared	prepared	JJ
cord-021419-nypnib0h	815	19	stable	stable	JJ
cord-021419-nypnib0h	815	20	iminium	iminium	NN
cord-021419-nypnib0h	815	21	salts	salt	NNS
cord-021419-nypnib0h	815	22	(	(	-LRB-
cord-021419-nypnib0h	815	23	see	see	VB
cord-021419-nypnib0h	815	24	Scheme	Scheme	NNP
cord-021419-nypnib0h	815	25	42	42	CD
cord-021419-nypnib0h	815	26	,	,	,
cord-021419-nypnib0h	815	27	conditions	condition	NNS
cord-021419-nypnib0h	815	28	a	a	DT
cord-021419-nypnib0h	815	29	)	)	-RRB-
cord-021419-nypnib0h	815	30	.	.	.
cord-021419-nypnib0h	816	1	In	in	IN
cord-021419-nypnib0h	816	2	the	the	DT
cord-021419-nypnib0h	816	3	case	case	NN
cord-021419-nypnib0h	816	4	of	of	IN
cord-021419-nypnib0h	816	5	aminomethylation	aminomethylation	NN
cord-021419-nypnib0h	816	6	of	of	IN
cord-021419-nypnib0h	816	7	compounds	compound	NNS
cord-021419-nypnib0h	816	8	149	149	CD
cord-021419-nypnib0h	816	9	with	with	IN
cord-021419-nypnib0h	816	10	polyfunctional	polyfunctional	JJ
cord-021419-nypnib0h	816	11	amines	amine	NNS
cord-021419-nypnib0h	816	12	,	,	,
cord-021419-nypnib0h	816	13	the	the	DT
cord-021419-nypnib0h	816	14	amino	amino	NN
cord-021419-nypnib0h	816	15	group	group	NN
cord-021419-nypnib0h	816	16	is	be	VBZ
cord-021419-nypnib0h	816	17	protected	protect	VBN
cord-021419-nypnib0h	816	18	with	with	IN
cord-021419-nypnib0h	816	19	Boc	Boc	NNP
cord-021419-nypnib0h	816	20	(	(	-LRB-
cord-021419-nypnib0h	816	21	see	see	VB
cord-021419-nypnib0h	816	22	Scheme	scheme	NN
cord-021419-nypnib0h	816	23	42	42	CD
cord-021419-nypnib0h	816	24	c	c	NN
cord-021419-nypnib0h	816	25	)	)	-RRB-
cord-021419-nypnib0h	816	26	and	and	CC
cord-021419-nypnib0h	816	27	then	then	RB
cord-021419-nypnib0h	816	28	deprotected	deprotecte	VBN
cord-021419-nypnib0h	816	29	with	with	IN
cord-021419-nypnib0h	816	30	acid	acid	NN
cord-021419-nypnib0h	816	31	(	(	-LRB-
cord-021419-nypnib0h	816	32	see	see	VB
cord-021419-nypnib0h	816	33	Scheme	scheme	NN
cord-021419-nypnib0h	816	34	42	42	CD
cord-021419-nypnib0h	816	35	d	d	NN
cord-021419-nypnib0h	816	36	)	)	-RRB-
cord-021419-nypnib0h	816	37	.	.	.
cord-021419-nypnib0h	817	1	The	the	DT
cord-021419-nypnib0h	817	2	reaction	reaction	NN
cord-021419-nypnib0h	817	3	of	of	IN
cord-021419-nypnib0h	817	4	compound	compound	NN
cord-021419-nypnib0h	817	5	149	149	CD
cord-021419-nypnib0h	817	6	with	with	IN
cord-021419-nypnib0h	817	7	N	n	CD
cord-021419-nypnib0h	817	8	,	,	,
cord-021419-nypnib0h	817	9	N	n	CD
cord-021419-nypnib0h	817	10	-	-	HYPH
cord-021419-nypnib0h	817	11	dimethylamino(methylene)ammonium	dimethylamino(methylene)ammonium	NN
cord-021419-nypnib0h	817	12	chloride	chloride	NN
cord-021419-nypnib0h	817	13	afforded	afford	VBD
cord-021419-nypnib0h	817	14	4-[(N	4-[(n	CD
cord-021419-nypnib0h	818	1	,	,	,
cord-021419-nypnib0h	818	2	N	n	CD
cord-021419-nypnib0h	818	3	-	-	HYPH
cord-021419-nypnib0h	818	4	dimethylamino)methyl]-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1-H	dimethylamino)methyl]-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1-h	NN
cord-021419-nypnib0h	818	5	-	-	HYPH
cord-021419-nypnib0h	818	6	benzo[cd	benzo[cd	NN
cord-021419-nypnib0h	818	7	]	]	-RRB-
cord-021419-nypnib0h	818	8	pyrene-2,6-dione	pyrene-2,6-dione	NNP
cord-021419-nypnib0h	818	9	hydrochloride	hydrochloride	NN
cord-021419-nypnib0h	818	10	(	(	-LRB-
cord-021419-nypnib0h	818	11	150a	150a	NN
cord-021419-nypnib0h	818	12	)	)	-RRB-
cord-021419-nypnib0h	818	13	.	.	.
cord-021419-nypnib0h	819	1	100	100	CD
cord-021419-nypnib0h	819	2	4-[(tert	4-[(tert	CD
cord-021419-nypnib0h	819	3	-	-	HYPH
cord-021419-nypnib0h	819	4	Butylamino)methyl]-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H	Butylamino)methyl]-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H	NNP
cord-021419-nypnib0h	819	5	-	-	HYPH
cord-021419-nypnib0h	819	6	benzo[cd	benzo[cd	NNP
cord-021419-nypnib0h	819	7	]	]	-RRB-
cord-021419-nypnib0h	820	1	pyrene-2,6-dione	pyrene-2,6-dione	NNP
cord-021419-nypnib0h	820	2	hydrochloride	hydrochloride	NN
cord-021419-nypnib0h	820	3	(	(	-LRB-
cord-021419-nypnib0h	820	4	150b	150b	NNP
cord-021419-nypnib0h	820	5	)	)	-RRB-
cord-021419-nypnib0h	820	6	is	be	VBZ
cord-021419-nypnib0h	820	7	produced	produce	VBN
cord-021419-nypnib0h	820	8	by	by	IN
cord-021419-nypnib0h	820	9	the	the	DT
cord-021419-nypnib0h	820	10	treatment	treatment	NN
cord-021419-nypnib0h	820	11	of	of	IN
cord-021419-nypnib0h	820	12	compound	compound	NN
cord-021419-nypnib0h	820	13	149	149	CD
cord-021419-nypnib0h	820	14	with	with	IN
cord-021419-nypnib0h	820	15	tertbutylmethylamine	tertbutylmethylamine	NN
cord-021419-nypnib0h	820	16	in	in	IN
cord-021419-nypnib0h	820	17	the	the	DT
cord-021419-nypnib0h	820	18	presence	presence	NN
cord-021419-nypnib0h	820	19	of	of	IN
cord-021419-nypnib0h	820	20	formaldehyde	formaldehyde	NN
cord-021419-nypnib0h	820	21	.	.	.
cord-021419-nypnib0h	821	1	The	the	DT
cord-021419-nypnib0h	821	2	treatment	treatment	NN
cord-021419-nypnib0h	821	3	of	of	IN
cord-021419-nypnib0h	821	4	compound	compound	NN
cord-021419-nypnib0h	821	5	149	149	CD
cord-021419-nypnib0h	821	6	with	with	IN
cord-021419-nypnib0h	821	7	tert	tert	NNP
cord-021419-nypnib0h	821	8	-	-	HYPH
cord-021419-nypnib0h	821	9	butylpiperidin-4-ylcarbamate	butylpiperidin-4-ylcarbamate	NNP
cord-021419-nypnib0h	821	10	in	in	IN
cord-021419-nypnib0h	821	11	the	the	DT
cord-021419-nypnib0h	821	12	presence	presence	NN
cord-021419-nypnib0h	821	13	of	of	IN
cord-021419-nypnib0h	821	14	a	a	DT
cord-021419-nypnib0h	821	15	formaldehyde	formaldehyde	NN
cord-021419-nypnib0h	821	16	solution	solution	NN
cord-021419-nypnib0h	821	17	gives	give	VBZ
cord-021419-nypnib0h	821	18	4-(4-Boc	4-(4-boc	CD
cord-021419-nypnib0h	821	19	-	-	HYPH
cord-021419-nypnib0h	821	20	aminopiperidinomethyl)-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1H	aminopiperidinomethyl)-3,5,7,10-tetrahydroxy-1,1,9-trimethyl-1h	NN
cord-021419-nypnib0h	821	21	-	-	HYPH
cord-021419-nypnib0h	821	22	benzo[cd	benzo[cd	NNP
cord-021419-nypnib0h	821	23	]	]	-RRB-
cord-021419-nypnib0h	821	24	pyrene-2,6-dione	pyrene-2,6-dione	NNP
cord-021419-nypnib0h	821	25	,	,	,
cord-021419-nypnib0h	821	26	which	which	WDT
cord-021419-nypnib0h	821	27	is	be	VBZ
cord-021419-nypnib0h	821	28	quantitatively	quantitatively	RB
cord-021419-nypnib0h	821	29	converted	convert	VBN
cord-021419-nypnib0h	821	30	to	to	IN
cord-021419-nypnib0h	821	31	the	the	DT
cord-021419-nypnib0h	821	32	corresponding	corresponding	JJ
cord-021419-nypnib0h	821	33	amine	amine	NN
cord-021419-nypnib0h	821	34	dihydrochloride	dihydrochloride	NN
cord-021419-nypnib0h	821	35	(	(	-LRB-
cord-021419-nypnib0h	821	36	150c	150c	CD
cord-021419-nypnib0h	821	37	)	)	-RRB-
cord-021419-nypnib0h	821	38	upon	upon	IN
cord-021419-nypnib0h	821	39	the	the	DT
cord-021419-nypnib0h	821	40	treatment	treatment	NN
cord-021419-nypnib0h	821	41	with	with	IN
cord-021419-nypnib0h	821	42	HCl7MeOH	HCl7MeOH	NNP
cord-021419-nypnib0h	821	43	.	.	.
cord-021419-nypnib0h	822	1	The	the	DT
cord-021419-nypnib0h	822	2	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	822	3	activity	activity	NN
cord-021419-nypnib0h	822	4	(	(	-LRB-
cord-021419-nypnib0h	822	5	IC	IC	NNP
cord-021419-nypnib0h	822	6	50	50	CD
cord-021419-nypnib0h	822	7	)	)	-RRB-
cord-021419-nypnib0h	822	8	was	be	VBD
cord-021419-nypnib0h	822	9	evaluated	evaluate	VBN
cord-021419-nypnib0h	822	10	by	by	IN
cord-021419-nypnib0h	822	11	the	the	DT
cord-021419-nypnib0h	822	12	colorimetric	colorimetric	JJ
cord-021419-nypnib0h	822	13	determination	determination	NN
cord-021419-nypnib0h	822	14	of	of	IN
cord-021419-nypnib0h	822	15	cell	cell	NN
cord-021419-nypnib0h	822	16	metabolic	metabolic	JJ
cord-021419-nypnib0h	822	17	activity	activity	NN
cord-021419-nypnib0h	822	18	(	(	-LRB-
cord-021419-nypnib0h	822	19	MTT	MTT	NNP
cord-021419-nypnib0h	822	20	assay	assay	NN
cord-021419-nypnib0h	822	21	)	)	-RRB-
cord-021419-nypnib0h	822	22	using	use	VBG
cord-021419-nypnib0h	822	23	a	a	DT
cord-021419-nypnib0h	822	24	standard	standard	JJ
cord-021419-nypnib0h	822	25	procedure	procedure	NN
cord-021419-nypnib0h	822	26	in	in	IN
cord-021419-nypnib0h	822	27	eight	eight	CD
cord-021419-nypnib0h	822	28	tumour	tumour	NN
cord-021419-nypnib0h	822	29	cell	cell	NN
cord-021419-nypnib0h	822	30	lines	line	NNS
cord-021419-nypnib0h	822	31	,	,	,
cord-021419-nypnib0h	822	32	including	include	VBG
cord-021419-nypnib0h	822	33	both	both	DT
cord-021419-nypnib0h	822	34	drug	drug	NN
cord-021419-nypnib0h	822	35	-	-	HYPH
cord-021419-nypnib0h	822	36	sensitive	sensitive	JJ
cord-021419-nypnib0h	822	37	and	and	CC
cord-021419-nypnib0h	822	38	drug	drug	NN
cord-021419-nypnib0h	822	39	-	-	HYPH
cord-021419-nypnib0h	822	40	resistant	resistant	JJ
cord-021419-nypnib0h	822	41	cell	cell	NN
cord-021419-nypnib0h	822	42	lines	line	NNS
cord-021419-nypnib0h	822	43	.	.	.
cord-021419-nypnib0h	823	1	100	100	CD
cord-021419-nypnib0h	824	1	The	the	DT
cord-021419-nypnib0h	824	2	resulting	result	VBG
cord-021419-nypnib0h	824	3	compounds	compound	NNS
cord-021419-nypnib0h	824	4	inhibit	inhibit	VBP
cord-021419-nypnib0h	824	5	tumour	tumour	NN
cord-021419-nypnib0h	824	6	cell	cell	NN
cord-021419-nypnib0h	824	7	proliferation	proliferation	NN
cord-021419-nypnib0h	824	8	in	in	IN
cord-021419-nypnib0h	824	9	a	a	DT
cord-021419-nypnib0h	824	10	low	low	JJ
cord-021419-nypnib0h	824	11	submicromolar	submicromolar	NN
cord-021419-nypnib0h	824	12	to	to	IN
cord-021419-nypnib0h	824	13	micromolar	micromolar	JJ
cord-021419-nypnib0h	824	14	concentration	concentration	NN
cord-021419-nypnib0h	824	15	range	range	NN
cord-021419-nypnib0h	824	16	,	,	,
cord-021419-nypnib0h	824	17	similar	similar	JJ
cord-021419-nypnib0h	824	18	to	to	IN
cord-021419-nypnib0h	824	19	that	that	DT
cord-021419-nypnib0h	824	20	of	of	IN
cord-021419-nypnib0h	824	21	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	824	22	(	(	-LRB-
cord-021419-nypnib0h	824	23	138a	138a	CD
cord-021419-nypnib0h	824	24	)	)	-RRB-
cord-021419-nypnib0h	824	25	.	.	.
cord-021419-nypnib0h	825	1	However	however	RB
cord-021419-nypnib0h	825	2	,	,	,
cord-021419-nypnib0h	825	3	most	most	JJS
cord-021419-nypnib0h	825	4	of	of	IN
cord-021419-nypnib0h	825	5	these	these	DT
cord-021419-nypnib0h	825	6	compounds	compound	NNS
cord-021419-nypnib0h	825	7	significantly	significantly	RB
cord-021419-nypnib0h	825	8	outperform	outperform	VBP
cord-021419-nypnib0h	825	9	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	825	10	in	in	IN
cord-021419-nypnib0h	825	11	terms	term	NNS
cord-021419-nypnib0h	825	12	of	of	IN
cord-021419-nypnib0h	825	13	the	the	DT
cord-021419-nypnib0h	825	14	drug	drug	NN
cord-021419-nypnib0h	825	15	-	-	HYPH
cord-021419-nypnib0h	825	16	resistance	resistance	NN
cord-021419-nypnib0h	825	17	index	index	NN
cord-021419-nypnib0h	825	18	.	.	.
cord-021419-nypnib0h	826	1	These	these	DT
cord-021419-nypnib0h	826	2	compounds	compound	NNS
cord-021419-nypnib0h	826	3	block	block	VBP
cord-021419-nypnib0h	826	4	the	the	DT
cord-021419-nypnib0h	826	5	growth	growth	NN
cord-021419-nypnib0h	826	6	of	of	IN
cord-021419-nypnib0h	826	7	the	the	DT
cord-021419-nypnib0h	826	8	wild	wild	JJ
cord-021419-nypnib0h	826	9	-	-	HYPH
cord-021419-nypnib0h	826	10	type	type	NN
cord-021419-nypnib0h	826	11	cell	cell	NN
cord-021419-nypnib0h	826	12	lines	line	NNS
cord-021419-nypnib0h	826	13	K562	k562	XX
cord-021419-nypnib0h	826	14	and	and	CC
cord-021419-nypnib0h	826	15	HCT116	HCT116	NNP
cord-021419-nypnib0h	826	16	and	and	CC
cord-021419-nypnib0h	826	17	the	the	DT
cord-021419-nypnib0h	826	18	following	follow	VBG
cord-021419-nypnib0h	826	19	multidrugresistant	multidrugresistant	NN
cord-021419-nypnib0h	826	20	cell	cell	NN
cord-021419-nypnib0h	826	21	lines	line	NNS
cord-021419-nypnib0h	826	22	:	:	:
cord-021419-nypnib0h	826	23	the	the	DT
cord-021419-nypnib0h	826	24	K562/4	K562/4	NNP
cord-021419-nypnib0h	826	25	subline	subline	NN
cord-021419-nypnib0h	826	26	isogenic	isogenic	JJ
cord-021419-nypnib0h	826	27	to	to	IN
cord-021419-nypnib0h	826	28	P	p	NN
cord-021419-nypnib0h	826	29	-	-	HYPH
cord-021419-nypnib0h	826	30	glycoprotein	glycoprotein	NN
cord-021419-nypnib0h	826	31	(	(	-LRB-
cord-021419-nypnib0h	826	32	Pgp)-positive	pgp)-positive	JJ
cord-021419-nypnib0h	826	33	multidrug	multidrug	NN
cord-021419-nypnib0h	826	34	resistance	resistance	NN
cord-021419-nypnib0h	826	35	and	and	CC
cord-021419-nypnib0h	826	36	the	the	DT
cord-021419-nypnib0h	826	37	HCT116p53ko	HCT116p53ko	NNP
cord-021419-nypnib0h	826	38	subline	subline	NN
cord-021419-nypnib0h	826	39	with	with	IN
cord-021419-nypnib0h	826	40	p53	p53	NN
cord-021419-nypnib0h	826	41	gene	gene	NN
cord-021419-nypnib0h	826	42	deletion	deletion	NN
cord-021419-nypnib0h	826	43	.	.	.
cord-021419-nypnib0h	827	1	The	the	DT
cord-021419-nypnib0h	827	2	development	development	NN
cord-021419-nypnib0h	827	3	of	of	IN
cord-021419-nypnib0h	827	4	multidrug	multidrug	NN
cord-021419-nypnib0h	827	5	resistance	resistance	NN
cord-021419-nypnib0h	827	6	in	in	IN
cord-021419-nypnib0h	827	7	these	these	DT
cord-021419-nypnib0h	827	8	tumour	tumour	NN
cord-021419-nypnib0h	827	9	cell	cell	NN
cord-021419-nypnib0h	827	10	lines	line	NNS
cord-021419-nypnib0h	827	11	is	be	VBZ
cord-021419-nypnib0h	827	12	the	the	DT
cord-021419-nypnib0h	827	13	crucial	crucial	JJ
cord-021419-nypnib0h	827	14	factor	factor	NN
cord-021419-nypnib0h	827	15	responsible	responsible	JJ
cord-021419-nypnib0h	827	16	for	for	IN
cord-021419-nypnib0h	827	17	a	a	DT
cord-021419-nypnib0h	827	18	decrease	decrease	NN
cord-021419-nypnib0h	827	19	in	in	IN
cord-021419-nypnib0h	827	20	activity	activity	NN
cord-021419-nypnib0h	827	21	of	of	IN
cord-021419-nypnib0h	827	22	antitumour	antitumour	JJ
cord-021419-nypnib0h	827	23	drugs	drug	NNS
cord-021419-nypnib0h	827	24	.	.	.
cord-021419-nypnib0h	828	1	As	as	IN
cord-021419-nypnib0h	828	2	opposed	oppose	VBN
cord-021419-nypnib0h	828	3	to	to	TO
cord-021419-nypnib0h	828	4	compound	compound	VB
cord-021419-nypnib0h	828	5	149	149	CD
cord-021419-nypnib0h	828	6	,	,	,
cord-021419-nypnib0h	828	7	derivatives	derivative	NNS
cord-021419-nypnib0h	828	8	150a	150a	NN
cord-021419-nypnib0h	828	9	±	±	NNP
cord-021419-nypnib0h	828	10	c	c	NN
cord-021419-nypnib0h	828	11	show	show	VBP
cord-021419-nypnib0h	828	12	a	a	DT
cord-021419-nypnib0h	828	13	high	high	JJ
cord-021419-nypnib0h	828	14	level	level	NN
cord-021419-nypnib0h	828	15	of	of	IN
cord-021419-nypnib0h	828	16	induced	induce	VBN
cord-021419-nypnib0h	828	17	apoptosis	apoptosis	NN
cord-021419-nypnib0h	828	18	in	in	IN
cord-021419-nypnib0h	828	19	the	the	DT
cord-021419-nypnib0h	828	20	T24	T24	NNP
cord-021419-nypnib0h	828	21	bladder	bladder	NN
cord-021419-nypnib0h	828	22	cancer	cancer	NN
cord-021419-nypnib0h	828	23	cell	cell	NN
cord-021419-nypnib0h	828	24	line	line	NN
cord-021419-nypnib0h	828	25	model	model	NN
cord-021419-nypnib0h	828	26	.	.	.
cord-021419-nypnib0h	829	1	The	the	DT
cord-021419-nypnib0h	829	2	introduction	introduction	NN
cord-021419-nypnib0h	829	3	of	of	IN
cord-021419-nypnib0h	829	4	the	the	DT
cord-021419-nypnib0h	829	5	4-aminomethyl	4-aminomethyl	CD
cord-021419-nypnib0h	829	6	moiety	moiety	NN
cord-021419-nypnib0h	829	7	enhances	enhance	VBZ
cord-021419-nypnib0h	829	8	the	the	DT
cord-021419-nypnib0h	829	9	DNA	dna	NN
cord-021419-nypnib0h	829	10	-	-	HYPH
cord-021419-nypnib0h	829	11	binding	bind	VBG
cord-021419-nypnib0h	829	12	affinity	affinity	NN
cord-021419-nypnib0h	829	13	and	and	CC
cord-021419-nypnib0h	829	14	the	the	DT
cord-021419-nypnib0h	829	15	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	829	16	activity	activity	NN
cord-021419-nypnib0h	829	17	against	against	IN
cord-021419-nypnib0h	829	18	DNA	dna	NN
cord-021419-nypnib0h	830	1	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	830	2	I.	I.	NNP
cord-021419-nypnib0h	830	3	Hence	Hence	NNP
cord-021419-nypnib0h	830	4	,	,	,
cord-021419-nypnib0h	830	5	compound	compound	NN
cord-021419-nypnib0h	830	6	150c	150c	NNP
cord-021419-nypnib0h	830	7	is	be	VBZ
cord-021419-nypnib0h	830	8	the	the	DT
cord-021419-nypnib0h	830	9	most	most	RBS
cord-021419-nypnib0h	830	10	promising	promising	JJ
cord-021419-nypnib0h	830	11	candidate	candidate	NN
cord-021419-nypnib0h	830	12	for	for	IN
cord-021419-nypnib0h	830	13	preclinical	preclinical	JJ
cord-021419-nypnib0h	830	14	trials	trial	NNS
cord-021419-nypnib0h	830	15	.	.	.
cord-021419-nypnib0h	831	1	Based	base	VBN
cord-021419-nypnib0h	831	2	on	on	IN
cord-021419-nypnib0h	831	3	these	these	DT
cord-021419-nypnib0h	831	4	studies	study	NNS
cord-021419-nypnib0h	831	5	,	,	,
cord-021419-nypnib0h	831	6	methods	method	NNS
cord-021419-nypnib0h	831	7	were	be	VBD
cord-021419-nypnib0h	831	8	developed	develop	VBN
cord-021419-nypnib0h	831	9	for	for	IN
cord-021419-nypnib0h	831	10	chemical	chemical	JJ
cord-021419-nypnib0h	831	11	modification	modification	NN
cord-021419-nypnib0h	831	12	of	of	IN
cord-021419-nypnib0h	831	13	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	831	14	(	(	-LRB-
cord-021419-nypnib0h	831	15	149	149	CD
cord-021419-nypnib0h	831	16	)	)	-RRB-
cord-021419-nypnib0h	831	17	.	.	.
cord-021419-nypnib0h	832	1	Series	Series	NNP
cord-021419-nypnib0h	832	2	of	of	IN
cord-021419-nypnib0h	832	3	new	new	JJ
cord-021419-nypnib0h	832	4	analogues	analogue	NNS
cord-021419-nypnib0h	832	5	,	,	,
cord-021419-nypnib0h	832	6	water	water	NN
cord-021419-nypnib0h	832	7	-	-	HYPH
cord-021419-nypnib0h	832	8	soluble	soluble	JJ
cord-021419-nypnib0h	832	9	salts	salt	NNS
cord-021419-nypnib0h	832	10	of	of	IN
cord-021419-nypnib0h	832	11	amino	amino	NN
cord-021419-nypnib0h	832	12	-	-	HYPH
cord-021419-nypnib0h	832	13	containing	contain	VBG
cord-021419-nypnib0h	832	14	derivatives	derivative	NNS
cord-021419-nypnib0h	832	15	,	,	,
cord-021419-nypnib0h	832	16	were	be	VBD
cord-021419-nypnib0h	832	17	synthesized	synthesize	VBN
cord-021419-nypnib0h	832	18	and	and	CC
cord-021419-nypnib0h	832	19	they	-PRON-	PRP
cord-021419-nypnib0h	832	20	were	be	VBD
cord-021419-nypnib0h	832	21	shown	show	VBN
cord-021419-nypnib0h	832	22	to	to	TO
cord-021419-nypnib0h	832	23	exhibit	exhibit	VB
cord-021419-nypnib0h	832	24	high	high	JJ
cord-021419-nypnib0h	832	25	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	832	26	activity	activity	NN
cord-021419-nypnib0h	832	27	against	against	IN
cord-021419-nypnib0h	832	28	many	many	JJ
cord-021419-nypnib0h	832	29	tumour	tumour	NN
cord-021419-nypnib0h	832	30	cell	cell	NN
cord-021419-nypnib0h	832	31	lines	line	NNS
cord-021419-nypnib0h	832	32	and	and	CC
cord-021419-nypnib0h	832	33	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	832	34	activity	activity	NN
cord-021419-nypnib0h	832	35	against	against	IN
cord-021419-nypnib0h	832	36	various	various	JJ
cord-021419-nypnib0h	832	37	targets	target	NNS
cord-021419-nypnib0h	832	38	.	.	.
cord-021419-nypnib0h	833	1	100	100	CD
cord-021419-nypnib0h	834	1	The	the	DT
cord-021419-nypnib0h	834	2	value	value	NN
cord-021419-nypnib0h	834	3	of	of	IN
cord-021419-nypnib0h	834	4	these	these	DT
cord-021419-nypnib0h	834	5	studies	study	NNS
cord-021419-nypnib0h	834	6	is	be	VBZ
cord-021419-nypnib0h	834	7	that	that	IN
cord-021419-nypnib0h	834	8	the	the	DT
cord-021419-nypnib0h	834	9	majority	majority	NN
cord-021419-nypnib0h	834	10	of	of	IN
cord-021419-nypnib0h	834	11	aminomethyl	aminomethyl	NNP
cord-021419-nypnib0h	834	12	derivatives	derivative	NNS
cord-021419-nypnib0h	834	13	of	of	IN
cord-021419-nypnib0h	834	14	heliomycin	heliomycin	NNS
cord-021419-nypnib0h	834	15	are	be	VBP
cord-021419-nypnib0h	834	16	active	active	JJ
cord-021419-nypnib0h	834	17	against	against	IN
cord-021419-nypnib0h	834	18	both	both	DT
cord-021419-nypnib0h	834	19	wild	wild	JJ
cord-021419-nypnib0h	834	20	-	-	HYPH
cord-021419-nypnib0h	834	21	type	type	NN
cord-021419-nypnib0h	834	22	and	and	CC
cord-021419-nypnib0h	834	23	drugresistant	drugresistant	JJ
cord-021419-nypnib0h	834	24	cancer	cancer	NN
cord-021419-nypnib0h	834	25	cells	cell	NNS
cord-021419-nypnib0h	834	26	at	at	IN
cord-021419-nypnib0h	834	27	micromolar	micromolar	NNP
cord-021419-nypnib0h	834	28	or	or	CC
cord-021419-nypnib0h	834	29	submicromolar	submicromolar	NNP
cord-021419-nypnib0h	834	30	concentrations	concentration	NNS
cord-021419-nypnib0h	834	31	.	.	.
cord-021419-nypnib0h	835	1	The	the	DT
cord-021419-nypnib0h	835	2	development	development	NN
cord-021419-nypnib0h	835	3	of	of	IN
cord-021419-nypnib0h	835	4	new	new	JJ
cord-021419-nypnib0h	835	5	-	-	HYPH
cord-021419-nypnib0h	835	6	generation	generation	NN
cord-021419-nypnib0h	835	7	drugs	drug	NNS
cord-021419-nypnib0h	835	8	is	be	VBZ
cord-021419-nypnib0h	835	9	a	a	DT
cord-021419-nypnib0h	835	10	challenging	challenging	JJ
cord-021419-nypnib0h	835	11	problem	problem	NN
cord-021419-nypnib0h	835	12	because	because	IN
cord-021419-nypnib0h	835	13	of	of	IN
cord-021419-nypnib0h	835	14	the	the	DT
cord-021419-nypnib0h	835	15	increasing	increase	VBG
cord-021419-nypnib0h	835	16	risk	risk	NN
cord-021419-nypnib0h	835	17	of	of	IN
cord-021419-nypnib0h	835	18	the	the	DT
cord-021419-nypnib0h	835	19	development	development	NN
cord-021419-nypnib0h	835	20	of	of	IN
cord-021419-nypnib0h	835	21	drug	drug	NN
cord-021419-nypnib0h	835	22	resistance	resistance	NN
cord-021419-nypnib0h	835	23	in	in	IN
cord-021419-nypnib0h	835	24	microorganisms	microorganism	NNS
cord-021419-nypnib0h	835	25	.	.	.
cord-021419-nypnib0h	836	1	Different	different	JJ
cord-021419-nypnib0h	836	2	approaches	approach	NNS
cord-021419-nypnib0h	836	3	to	to	IN
cord-021419-nypnib0h	836	4	the	the	DT
cord-021419-nypnib0h	836	5	search	search	NN
cord-021419-nypnib0h	836	6	for	for	IN
cord-021419-nypnib0h	836	7	new	new	JJ
cord-021419-nypnib0h	836	8	compounds	compound	NNS
cord-021419-nypnib0h	836	9	were	be	VBD
cord-021419-nypnib0h	836	10	developed	develop	VBN
cord-021419-nypnib0h	836	11	in	in	IN
cord-021419-nypnib0h	836	12	recent	recent	JJ
cord-021419-nypnib0h	836	13	years	year	NNS
cord-021419-nypnib0h	836	14	.	.	.
cord-021419-nypnib0h	837	1	Particular	particular	JJ
cord-021419-nypnib0h	837	2	attention	attention	NN
cord-021419-nypnib0h	837	3	is	be	VBZ
cord-021419-nypnib0h	837	4	given	give	VBN
cord-021419-nypnib0h	837	5	to	to	IN
cord-021419-nypnib0h	837	6	semi	semi	JJ
cord-021419-nypnib0h	837	7	-	-	JJ
cord-021419-nypnib0h	837	8	synthetic	synthetic	JJ
cord-021419-nypnib0h	837	9	derivatives	derivative	NNS
cord-021419-nypnib0h	837	10	based	base	VBN
cord-021419-nypnib0h	837	11	on	on	IN
cord-021419-nypnib0h	837	12	available	available	JJ
cord-021419-nypnib0h	837	13	natural	natural	JJ
cord-021419-nypnib0h	837	14	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	837	15	,	,	,
cord-021419-nypnib0h	837	16	since	since	IN
cord-021419-nypnib0h	837	17	there	there	EX
cord-021419-nypnib0h	837	18	are	be	VBP
cord-021419-nypnib0h	837	19	numerous	numerous	JJ
cord-021419-nypnib0h	837	20	examples	example	NNS
cord-021419-nypnib0h	837	21	of	of	IN
cord-021419-nypnib0h	837	22	the	the	DT
cord-021419-nypnib0h	837	23	successful	successful	JJ
cord-021419-nypnib0h	837	24	application	application	NN
cord-021419-nypnib0h	837	25	of	of	IN
cord-021419-nypnib0h	837	26	this	this	DT
cord-021419-nypnib0h	837	27	approach	approach	NN
cord-021419-nypnib0h	837	28	.	.	.
cord-021419-nypnib0h	838	1	Some	some	DT
cord-021419-nypnib0h	838	2	semi	semi	JJ
cord-021419-nypnib0h	838	3	-	-	JJ
cord-021419-nypnib0h	838	4	synthetic	synthetic	JJ
cord-021419-nypnib0h	838	5	derivatives	derivative	NNS
cord-021419-nypnib0h	838	6	based	base	VBN
cord-021419-nypnib0h	838	7	on	on	IN
cord-021419-nypnib0h	838	8	macrocyclic	macrocyclic	NNP
cord-021419-nypnib0h	838	9	glycopeptides	glycopeptides	NNP
cord-021419-nypnib0h	838	10	have	have	VBP
cord-021419-nypnib0h	838	11	advantages	advantage	NNS
cord-021419-nypnib0h	838	12	over	over	IN
cord-021419-nypnib0h	838	13	the	the	DT
cord-021419-nypnib0h	838	14	gold	gold	JJ
cord-021419-nypnib0h	838	15	standard	standard	JJ
cord-021419-nypnib0h	838	16	chemotherapeutic	chemotherapeutic	JJ
cord-021419-nypnib0h	838	17	agent	agent	NN
cord-021419-nypnib0h	838	18	Ð	Ð	NNP
cord-021419-nypnib0h	838	19	vancomycin	vancomycin	NNP
cord-021419-nypnib0h	838	20	.	.	.
cord-021419-nypnib0h	839	1	3	3	CD
cord-021419-nypnib0h	839	2	,	,	,
cord-021419-nypnib0h	839	3	7	7	CD
cord-021419-nypnib0h	839	4	,	,	,
cord-021419-nypnib0h	839	5	10	10	CD
cord-021419-nypnib0h	840	1	The	the	DT
cord-021419-nypnib0h	840	2	distinguishing	distinguishing	JJ
cord-021419-nypnib0h	840	3	features	feature	NNS
cord-021419-nypnib0h	840	4	of	of	IN
cord-021419-nypnib0h	840	5	new	new	JJ
cord-021419-nypnib0h	840	6	representatives	representative	NNS
cord-021419-nypnib0h	840	7	of	of	IN
cord-021419-nypnib0h	840	8	this	this	DT
cord-021419-nypnib0h	840	9	class	class	NN
cord-021419-nypnib0h	840	10	are	be	VBP
cord-021419-nypnib0h	840	11	selectivity	selectivity	NN
cord-021419-nypnib0h	840	12	against	against	IN
cord-021419-nypnib0h	840	13	multidrug	multidrug	NN
cord-021419-nypnib0h	840	14	-	-	HYPH
cord-021419-nypnib0h	840	15	resistant	resistant	JJ
cord-021419-nypnib0h	840	16	pathogenic	pathogenic	JJ
cord-021419-nypnib0h	840	17	bacteria	bacteria	NNS
cord-021419-nypnib0h	840	18	and	and	CC
cord-021419-nypnib0h	840	19	higher	high	JJR
cord-021419-nypnib0h	840	20	bioavailability	bioavailability	NN
cord-021419-nypnib0h	840	21	.	.	.
cord-021419-nypnib0h	841	1	The	the	DT
cord-021419-nypnib0h	841	2	new	new	JJ
cord-021419-nypnib0h	841	3	semi	semi	JJ
cord-021419-nypnib0h	841	4	-	-	JJ
cord-021419-nypnib0h	841	5	synthetic	synthetic	JJ
cord-021419-nypnib0h	841	6	vancomycin	vancomycin	NN
cord-021419-nypnib0h	841	7	analogue	analogue	NN
cord-021419-nypnib0h	841	8	Telavancin	Telavancin	NNPS
cord-021419-nypnib0h	841	9	(	(	-LRB-
cord-021419-nypnib0h	841	10	Vibativ	Vibativ	NNP
cord-021419-nypnib0h	841	11	)	)	-RRB-
cord-021419-nypnib0h	841	12	(	(	-LRB-
cord-021419-nypnib0h	841	13	manufactured	manufacture	VBN
cord-021419-nypnib0h	841	14	by	by	IN
cord-021419-nypnib0h	841	15	Theravance	Theravance	NNP
cord-021419-nypnib0h	841	16	and	and	CC
cord-021419-nypnib0h	841	17	Astellas	Astellas	NNP
cord-021419-nypnib0h	841	18	Pharma	Pharma	NNP
cord-021419-nypnib0h	841	19	,	,	,
cord-021419-nypnib0h	841	20	US	US	NNP
cord-021419-nypnib0h	841	21	)	)	-RRB-
cord-021419-nypnib0h	841	22	was	be	VBD
cord-021419-nypnib0h	841	23	approved	approve	VBN
cord-021419-nypnib0h	841	24	for	for	IN
cord-021419-nypnib0h	841	25	use	use	NN
cord-021419-nypnib0h	841	26	in	in	IN
cord-021419-nypnib0h	841	27	the	the	DT
cord-021419-nypnib0h	841	28	United	United	NNP
cord-021419-nypnib0h	841	29	States	States	NNP
cord-021419-nypnib0h	841	30	and	and	CC
cord-021419-nypnib0h	841	31	Europe	Europe	NNP
cord-021419-nypnib0h	841	32	.	.	.
cord-021419-nypnib0h	842	1	Two	two	CD
cord-021419-nypnib0h	842	2	semi	semi	JJ
cord-021419-nypnib0h	842	3	-	-	JJ
cord-021419-nypnib0h	842	4	synthetic	synthetic	JJ
cord-021419-nypnib0h	842	5	derivatives	derivative	NNS
cord-021419-nypnib0h	842	6	of	of	IN
cord-021419-nypnib0h	842	7	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	842	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	842	9	have	have	VBP
cord-021419-nypnib0h	842	10	completed	complete	VBN
cord-021419-nypnib0h	842	11	phase	phase	NN
cord-021419-nypnib0h	842	12	3	3	CD
cord-021419-nypnib0h	842	13	clinical	clinical	JJ
cord-021419-nypnib0h	842	14	trials	trial	NNS
cord-021419-nypnib0h	842	15	and	and	CC
cord-021419-nypnib0h	842	16	were	be	VBD
cord-021419-nypnib0h	842	17	approved	approve	VBN
cord-021419-nypnib0h	842	18	by	by	IN
cord-021419-nypnib0h	842	19	the	the	DT
cord-021419-nypnib0h	842	20	United	United	NNP
cord-021419-nypnib0h	842	21	State	State	NNP
cord-021419-nypnib0h	842	22	Food	Food	NNP
cord-021419-nypnib0h	842	23	and	and	CC
cord-021419-nypnib0h	842	24	Drug	Drug	NNP
cord-021419-nypnib0h	842	25	Administration	Administration	NNP
cord-021419-nypnib0h	842	26	(	(	-LRB-
cord-021419-nypnib0h	842	27	FDA	FDA	NNP
cord-021419-nypnib0h	842	28	)	)	-RRB-
cord-021419-nypnib0h	843	1	:	:	:
cord-021419-nypnib0h	843	2	chloroeremomycin	chloroeremomycin	NNP
cord-021419-nypnib0h	843	3	(	(	-LRB-
cord-021419-nypnib0h	843	4	discovered	discover	VBN
cord-021419-nypnib0h	843	5	by	by	IN
cord-021419-nypnib0h	843	6	Eli	Eli	NNP
cord-021419-nypnib0h	843	7	Lilly	Lilly	NNP
cord-021419-nypnib0h	843	8	,	,	,
cord-021419-nypnib0h	843	9	acquired	acquire	VBN
cord-021419-nypnib0h	843	10	by	by	IN
cord-021419-nypnib0h	843	11	The	the	DT
cord-021419-nypnib0h	843	12	Medicine	Medicine	NNP
cord-021419-nypnib0h	843	13	Co	Co	NNP
cord-021419-nypnib0h	843	14	in	in	IN
cord-021419-nypnib0h	843	15	2009	2009	CD
cord-021419-nypnib0h	843	16	)	)	-RRB-
cord-021419-nypnib0h	843	17	and	and	CC
cord-021419-nypnib0h	843	18	dalbavancin	dalbavancin	NNS
cord-021419-nypnib0h	843	19	(	(	-LRB-
cord-021419-nypnib0h	843	20	discovered	discover	VBN
cord-021419-nypnib0h	843	21	by	by	IN
cord-021419-nypnib0h	843	22	LePetit	LePetit	NNP
cord-021419-nypnib0h	843	23	;	;	:
cord-021419-nypnib0h	843	24	acquired	acquire	VBN
cord-021419-nypnib0h	843	25	by	by	IN
cord-021419-nypnib0h	843	26	Pfizer	Pfizer	NNP
cord-021419-nypnib0h	843	27	in	in	IN
cord-021419-nypnib0h	843	28	2005	2005	CD
cord-021419-nypnib0h	843	29	)	)	-RRB-
cord-021419-nypnib0h	843	30	.	.	.
cord-021419-nypnib0h	844	1	8	8	CD
cord-021419-nypnib0h	844	2	,	,	,
cord-021419-nypnib0h	844	3	10	10	CD
cord-021419-nypnib0h	845	1	The	the	DT
cord-021419-nypnib0h	845	2	drawbacks	drawback	NNS
cord-021419-nypnib0h	845	3	of	of	IN
cord-021419-nypnib0h	845	4	vancomycin	vancomycin	NNS
cord-021419-nypnib0h	845	5	are	be	VBP
cord-021419-nypnib0h	845	6	the	the	DT
cord-021419-nypnib0h	845	7	poor	poor	JJ
cord-021419-nypnib0h	845	8	accumulation	accumulation	NN
cord-021419-nypnib0h	845	9	within	within	IN
cord-021419-nypnib0h	845	10	tissues	tissue	NNS
cord-021419-nypnib0h	845	11	,	,	,
cord-021419-nypnib0h	845	12	because	because	IN
cord-021419-nypnib0h	845	13	of	of	IN
cord-021419-nypnib0h	845	14	which	which	WDT
cord-021419-nypnib0h	845	15	it	-PRON-	PRP
cord-021419-nypnib0h	845	16	is	be	VBZ
cord-021419-nypnib0h	845	17	not	not	RB
cord-021419-nypnib0h	845	18	used	use	VBN
cord-021419-nypnib0h	845	19	in	in	IN
cord-021419-nypnib0h	845	20	the	the	DT
cord-021419-nypnib0h	845	21	treatment	treatment	NN
cord-021419-nypnib0h	845	22	of	of	IN
cord-021419-nypnib0h	845	23	,	,	,
cord-021419-nypnib0h	845	24	for	for	IN
cord-021419-nypnib0h	845	25	example	example	NN
cord-021419-nypnib0h	845	26	,	,	,
cord-021419-nypnib0h	845	27	pneumonia	pneumonia	NN
cord-021419-nypnib0h	845	28	,	,	,
cord-021419-nypnib0h	845	29	and	and	CC
cord-021419-nypnib0h	845	30	a	a	DT
cord-021419-nypnib0h	845	31	pronounced	pronounce	VBN
cord-021419-nypnib0h	845	32	pseudoallergic	pseudoallergic	JJ
cord-021419-nypnib0h	845	33	reaction	reaction	NN
cord-021419-nypnib0h	845	34	typical	typical	JJ
cord-021419-nypnib0h	845	35	of	of	IN
cord-021419-nypnib0h	845	36	glycopeptides	glycopeptide	NNS
cord-021419-nypnib0h	845	37	.	.	.
cord-021419-nypnib0h	846	1	Research	research	NN
cord-021419-nypnib0h	846	2	in	in	IN
cord-021419-nypnib0h	846	3	international	international	JJ
cord-021419-nypnib0h	846	4	cooperation	cooperation	NN
cord-021419-nypnib0h	846	5	showed	show	VBD
cord-021419-nypnib0h	846	6	the	the	DT
cord-021419-nypnib0h	846	7	promise	promise	NN
cord-021419-nypnib0h	846	8	of	of	IN
cord-021419-nypnib0h	846	9	chemical	chemical	JJ
cord-021419-nypnib0h	846	10	transformations	transformation	NNS
cord-021419-nypnib0h	846	11	of	of	IN
cord-021419-nypnib0h	846	12	the	the	DT
cord-021419-nypnib0h	846	13	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	846	14	eremomycin	eremomycin	NNS
cord-021419-nypnib0h	846	15	belonging	belong	VBG
cord-021419-nypnib0h	846	16	to	to	IN
cord-021419-nypnib0h	846	17	this	this	DT
cord-021419-nypnib0h	846	18	group	group	NN
cord-021419-nypnib0h	846	19	of	of	IN
cord-021419-nypnib0h	846	20	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	846	21	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	846	22	.	.	.
cord-021419-nypnib0h	847	1	Eremomycin	Eremomycin	NNP
cord-021419-nypnib0h	847	2	is	be	VBZ
cord-021419-nypnib0h	847	3	a	a	DT
cord-021419-nypnib0h	847	4	highly	highly	RB
cord-021419-nypnib0h	847	5	active	active	JJ
cord-021419-nypnib0h	847	6	domestic	domestic	JJ
cord-021419-nypnib0h	847	7	antibiotic	antibiotic	NN
cord-021419-nypnib0h	847	8	that	that	WDT
cord-021419-nypnib0h	847	9	suppresses	suppress	VBZ
cord-021419-nypnib0h	847	10	the	the	DT
cord-021419-nypnib0h	847	11	growth	growth	NN
cord-021419-nypnib0h	847	12	of	of	IN
cord-021419-nypnib0h	847	13	Gram	gram	NN
cord-021419-nypnib0h	847	14	-	-	HYPH
cord-021419-nypnib0h	847	15	positive	positive	JJ
cord-021419-nypnib0h	847	16	organisms	organism	NNS
cord-021419-nypnib0h	847	17	;	;	:
cord-021419-nypnib0h	847	18	it	-PRON-	PRP
cord-021419-nypnib0h	847	19	is	be	VBZ
cord-021419-nypnib0h	847	20	3	3	CD
cord-021419-nypnib0h	847	21	±	±	NNP
cord-021419-nypnib0h	847	22	5	5	CD
cord-021419-nypnib0h	847	23	times	time	NNS
cord-021419-nypnib0h	847	24	more	more	RBR
cord-021419-nypnib0h	847	25	effective	effective	JJ
cord-021419-nypnib0h	847	26	than	than	IN
cord-021419-nypnib0h	847	27	vancomycin	vancomycin	FW
cord-021419-nypnib0h	847	28	but	but	CC
cord-021419-nypnib0h	847	29	is	be	VBZ
cord-021419-nypnib0h	847	30	inactive	inactive	JJ
cord-021419-nypnib0h	847	31	against	against	IN
cord-021419-nypnib0h	847	32	drug	drug	NN
cord-021419-nypnib0h	847	33	-	-	HYPH
cord-021419-nypnib0h	847	34	resistant	resistant	JJ
cord-021419-nypnib0h	847	35	strains	strain	NNS
cord-021419-nypnib0h	847	36	of	of	IN
cord-021419-nypnib0h	847	37	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	847	38	and	and	CC
cord-021419-nypnib0h	847	39	enterococci	enterococci	NNS
cord-021419-nypnib0h	847	40	.	.	.
cord-021419-nypnib0h	848	1	6	6	CD
cord-021419-nypnib0h	849	1	Original	original	JJ
cord-021419-nypnib0h	849	2	approaches	approach	NNS
cord-021419-nypnib0h	849	3	and	and	CC
cord-021419-nypnib0h	849	4	methods	method	NNS
cord-021419-nypnib0h	849	5	were	be	VBD
cord-021419-nypnib0h	849	6	developed	develop	VBN
cord-021419-nypnib0h	849	7	under	under	IN
cord-021419-nypnib0h	849	8	the	the	DT
cord-021419-nypnib0h	849	9	supervision	supervision	NN
cord-021419-nypnib0h	849	10	of	of	IN
cord-021419-nypnib0h	849	11	Professor	Professor	NNP
cord-021419-nypnib0h	849	12	M.N.Preobrazhenskaya	M.N.Preobrazhenskaya	NNP
cord-021419-nypnib0h	849	13	in	in	IN
cord-021419-nypnib0h	849	14	the	the	DT
cord-021419-nypnib0h	849	15	Gause	Gause	NNP
cord-021419-nypnib0h	849	16	Institute	Institute	NNP
cord-021419-nypnib0h	849	17	of	of	IN
cord-021419-nypnib0h	849	18	New	New	NNP
cord-021419-nypnib0h	849	19	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	849	20	.	.	.
cord-021419-nypnib0h	850	1	These	these	DT
cord-021419-nypnib0h	850	2	methods	method	NNS
cord-021419-nypnib0h	850	3	can	can	MD
cord-021419-nypnib0h	850	4	be	be	VB
cord-021419-nypnib0h	850	5	applied	apply	VBN
cord-021419-nypnib0h	850	6	to	to	TO
cord-021419-nypnib0h	850	7	prepare	prepare	VB
cord-021419-nypnib0h	850	8	derivatives	derivative	NNS
cord-021419-nypnib0h	850	9	of	of	IN
cord-021419-nypnib0h	850	10	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	850	11	of	of	IN
cord-021419-nypnib0h	850	12	this	this	DT
cord-021419-nypnib0h	850	13	group	group	NN
cord-021419-nypnib0h	850	14	with	with	IN
cord-021419-nypnib0h	850	15	desired	desire	VBN
cord-021419-nypnib0h	850	16	properties	property	NNS
cord-021419-nypnib0h	850	17	.	.	.
cord-021419-nypnib0h	851	1	In	in	IN
cord-021419-nypnib0h	851	2	2006	2006	CD
cord-021419-nypnib0h	851	3	,	,	,
cord-021419-nypnib0h	851	4	the	the	DT
cord-021419-nypnib0h	851	5	method	method	NN
cord-021419-nypnib0h	851	6	for	for	IN
cord-021419-nypnib0h	851	7	the	the	DT
cord-021419-nypnib0h	851	8	synthesis	synthesis	NN
cord-021419-nypnib0h	851	9	of	of	IN
cord-021419-nypnib0h	851	10	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	851	11	analogues	analogue	NNS
cord-021419-nypnib0h	851	12	was	be	VBD
cord-021419-nypnib0h	851	13	protected	protect	VBN
cord-021419-nypnib0h	851	14	by	by	IN
cord-021419-nypnib0h	851	15	an	an	DT
cord-021419-nypnib0h	851	16	international	international	JJ
cord-021419-nypnib0h	851	17	patent	patent	NN
cord-021419-nypnib0h	851	18	.	.	.
cord-021419-nypnib0h	852	1	18	18	CD
cord-021419-nypnib0h	852	2	Promising	promising	JJ
cord-021419-nypnib0h	852	3	analogues	analogue	NNS
cord-021419-nypnib0h	852	4	,	,	,
cord-021419-nypnib0h	852	5	various	various	JJ
cord-021419-nypnib0h	852	6	N	n	CD
cord-021419-nypnib0h	852	7	H	h	NN
cord-021419-nypnib0h	852	8	-derivatives	-derivatives	:
cord-021419-nypnib0h	852	9	and	and	CC
cord-021419-nypnib0h	852	10	carboxamides	carboxamide	NNS
cord-021419-nypnib0h	852	11	of	of	IN
cord-021419-nypnib0h	852	12	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	852	13	,	,	,
cord-021419-nypnib0h	852	14	were	be	VBD
cord-021419-nypnib0h	852	15	synthesized	synthesize	VBN
cord-021419-nypnib0h	852	16	.	.	.
cord-021419-nypnib0h	853	1	These	these	DT
cord-021419-nypnib0h	853	2	derivatives	derivative	NNS
cord-021419-nypnib0h	853	3	compare	compare	VBP
cord-021419-nypnib0h	853	4	favourably	favourably	RB
cord-021419-nypnib0h	853	5	in	in	IN
cord-021419-nypnib0h	853	6	efficacy	efficacy	NN
cord-021419-nypnib0h	853	7	against	against	IN
cord-021419-nypnib0h	853	8	drug	drug	NN
cord-021419-nypnib0h	853	9	-	-	HYPH
cord-021419-nypnib0h	853	10	sensitive	sensitive	JJ
cord-021419-nypnib0h	853	11	and	and	CC
cord-021419-nypnib0h	853	12	drug	drug	NN
cord-021419-nypnib0h	853	13	-	-	HYPH
cord-021419-nypnib0h	853	14	resistant	resistant	JJ
cord-021419-nypnib0h	853	15	strains	strain	NNS
cord-021419-nypnib0h	853	16	of	of	IN
cord-021419-nypnib0h	853	17	staphylococci	staphylococcus	NNS
cord-021419-nypnib0h	853	18	and	and	CC
cord-021419-nypnib0h	853	19	enterococci	enterococci	NNS
cord-021419-nypnib0h	853	20	with	with	IN
cord-021419-nypnib0h	853	21	the	the	DT
cord-021419-nypnib0h	853	22	related	relate	VBN
cord-021419-nypnib0h	853	23	vancomycin	vancomycin	NN
cord-021419-nypnib0h	853	24	derivatives	derivative	NNS
cord-021419-nypnib0h	853	25	and	and	CC
cord-021419-nypnib0h	853	26	they	-PRON-	PRP
cord-021419-nypnib0h	853	27	are	be	VBP
cord-021419-nypnib0h	853	28	even	even	RB
cord-021419-nypnib0h	853	29	more	more	RBR
cord-021419-nypnib0h	853	30	effective	effective	JJ
cord-021419-nypnib0h	853	31	in	in	IN
cord-021419-nypnib0h	853	32	a	a	DT
cord-021419-nypnib0h	853	33	number	number	NN
cord-021419-nypnib0h	853	34	of	of	IN
cord-021419-nypnib0h	853	35	assays	assay	NNS
cord-021419-nypnib0h	853	36	.	.	.
cord-021419-nypnib0h	854	1	12	12	CD
cord-021419-nypnib0h	854	2	±	±	CD
cord-021419-nypnib0h	854	3	15	15	CD
cord-021419-nypnib0h	854	4	Some	some	DT
cord-021419-nypnib0h	854	5	carboxamides	carboxamide	NNS
cord-021419-nypnib0h	854	6	show	show	VBP
cord-021419-nypnib0h	854	7	no	no	DT
cord-021419-nypnib0h	854	8	allergenicity	allergenicity	NN
cord-021419-nypnib0h	854	9	.	.	.
cord-021419-nypnib0h	855	1	13	13	CD
cord-021419-nypnib0h	856	1	Other	other	JJ
cord-021419-nypnib0h	856	2	derivatives	derivative	NNS
cord-021419-nypnib0h	856	3	(	(	-LRB-
cord-021419-nypnib0h	857	1	e.g.	e.g.	RB
cord-021419-nypnib0h	857	2	,	,	,
cord-021419-nypnib0h	857	3	the	the	DT
cord-021419-nypnib0h	857	4	adamantane	adamantane	NNP
cord-021419-nypnib0h	857	5	derivative	derivative	NN
cord-021419-nypnib0h	857	6	of	of	IN
cord-021419-nypnib0h	857	7	eremomycin	eremomycin	NNP
cord-021419-nypnib0h	857	8	)	)	-RRB-
cord-021419-nypnib0h	857	9	are	be	VBP
cord-021419-nypnib0h	857	10	promising	promise	VBG
cord-021419-nypnib0h	857	11	as	as	IN
cord-021419-nypnib0h	857	12	a	a	DT
cord-021419-nypnib0h	857	13	protection	protection	NN
cord-021419-nypnib0h	857	14	against	against	IN
cord-021419-nypnib0h	857	15	biological	biological	JJ
cord-021419-nypnib0h	857	16	risks	risk	NNS
cord-021419-nypnib0h	857	17	because	because	IN
cord-021419-nypnib0h	857	18	they	-PRON-	PRP
cord-021419-nypnib0h	857	19	were	be	VBD
cord-021419-nypnib0h	857	20	found	find	VBN
cord-021419-nypnib0h	857	21	to	to	TO
cord-021419-nypnib0h	857	22	be	be	VB
cord-021419-nypnib0h	857	23	active	active	JJ
cord-021419-nypnib0h	857	24	against	against	IN
cord-021419-nypnib0h	857	25	the	the	DT
cord-021419-nypnib0h	857	26	bacterium	bacterium	NN
cord-021419-nypnib0h	857	27	Bacillus	bacillus	NN
cord-021419-nypnib0h	857	28	anthracis	anthracis	NN
cord-021419-nypnib0h	857	29	,	,	,
cord-021419-nypnib0h	857	30	including	include	VBG
cord-021419-nypnib0h	857	31	fluoroquinolone	fluoroquinolone	NN
cord-021419-nypnib0h	857	32	-	-	HYPH
cord-021419-nypnib0h	857	33	resistant	resistant	JJ
cord-021419-nypnib0h	857	34	strains	strain	NNS
cord-021419-nypnib0h	857	35	.	.	.
cord-021419-nypnib0h	858	1	15	15	CD
cord-021419-nypnib0h	858	2	High	high	JJ
cord-021419-nypnib0h	858	3	activity	activity	NN
cord-021419-nypnib0h	858	4	of	of	IN
cord-021419-nypnib0h	858	5	the	the	DT
cord-021419-nypnib0h	858	6	resulting	result	VBG
cord-021419-nypnib0h	858	7	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	858	8	glycopeptide	glycopeptide	NN
cord-021419-nypnib0h	858	9	derivatives	derivative	NNS
cord-021419-nypnib0h	858	10	can	can	MD
cord-021419-nypnib0h	858	11	be	be	VB
cord-021419-nypnib0h	858	12	attributed	attribute	VBN
cord-021419-nypnib0h	858	13	to	to	IN
cord-021419-nypnib0h	858	14	the	the	DT
cord-021419-nypnib0h	858	15	dual	dual	JJ
cord-021419-nypnib0h	858	16	mechanism	mechanism	NN
cord-021419-nypnib0h	858	17	of	of	IN
cord-021419-nypnib0h	858	18	action	action	NN
cord-021419-nypnib0h	858	19	on	on	IN
cord-021419-nypnib0h	858	20	Gram	gram	NN
cord-021419-nypnib0h	858	21	-	-	HYPH
cord-021419-nypnib0h	858	22	positive	positive	JJ
cord-021419-nypnib0h	858	23	bacteria	bacteria	NNS
cord-021419-nypnib0h	858	24	.	.	.
cord-021419-nypnib0h	859	1	20	20	CD
cord-021419-nypnib0h	859	2	,	,	,
cord-021419-nypnib0h	859	3	21	21	CD
cord-021419-nypnib0h	859	4	Modifications	modification	NNS
cord-021419-nypnib0h	859	5	of	of	IN
cord-021419-nypnib0h	859	6	aglycones	aglycone	NNS
cord-021419-nypnib0h	859	7	of	of	IN
cord-021419-nypnib0h	859	8	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	859	9	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	859	10	with	with	IN
cord-021419-nypnib0h	859	11	hydrophobic	hydrophobic	JJ
cord-021419-nypnib0h	859	12	substituents	substituent	NNS
cord-021419-nypnib0h	859	13	resulted	result	VBD
cord-021419-nypnib0h	859	14	in	in	IN
cord-021419-nypnib0h	859	15	the	the	DT
cord-021419-nypnib0h	859	16	discovery	discovery	NN
cord-021419-nypnib0h	859	17	of	of	IN
cord-021419-nypnib0h	859	18	a	a	DT
cord-021419-nypnib0h	859	19	new	new	JJ
cord-021419-nypnib0h	859	20	class	class	NN
cord-021419-nypnib0h	859	21	of	of	IN
cord-021419-nypnib0h	859	22	polycyclic	polycyclic	NN
cord-021419-nypnib0h	859	23	peptides	peptide	NNS
cord-021419-nypnib0h	859	24	active	active	JJ
cord-021419-nypnib0h	859	25	against	against	IN
cord-021419-nypnib0h	859	26	a	a	DT
cord-021419-nypnib0h	859	27	large	large	JJ
cord-021419-nypnib0h	859	28	group	group	NN
cord-021419-nypnib0h	859	29	of	of	IN
cord-021419-nypnib0h	859	30	enveloped	enveloped	JJ
cord-021419-nypnib0h	859	31	viruses	virus	NNS
cord-021419-nypnib0h	859	32	,	,	,
cord-021419-nypnib0h	859	33	such	such	JJ
cord-021419-nypnib0h	859	34	as	as	IN
cord-021419-nypnib0h	859	35	HIV	HIV	NNP
cord-021419-nypnib0h	859	36	23	23	CD
cord-021419-nypnib0h	859	37	or	or	CC
cord-021419-nypnib0h	859	38	hepatitis	hepatitis	NN
cord-021419-nypnib0h	859	39	C	C	NNP
cord-021419-nypnib0h	859	40	virus	virus	NN
cord-021419-nypnib0h	859	41	.	.	.
cord-021419-nypnib0h	860	1	25	25	CD
cord-021419-nypnib0h	860	2	Studies	study	NNS
cord-021419-nypnib0h	860	3	on	on	IN
cord-021419-nypnib0h	860	4	the	the	DT
cord-021419-nypnib0h	860	5	mechanisms	mechanism	NNS
cord-021419-nypnib0h	860	6	of	of	IN
cord-021419-nypnib0h	860	7	antiviral	antiviral	JJ
cord-021419-nypnib0h	860	8	activity	activity	NN
cord-021419-nypnib0h	860	9	are	be	VBP
cord-021419-nypnib0h	860	10	currently	currently	RB
cord-021419-nypnib0h	860	11	ongoing	ongoing	JJ
cord-021419-nypnib0h	860	12	.	.	.
cord-021419-nypnib0h	861	1	It	-PRON-	PRP
cord-021419-nypnib0h	861	2	was	be	VBD
cord-021419-nypnib0h	861	3	suggested	suggest	VBN
cord-021419-nypnib0h	861	4	that	that	IN
cord-021419-nypnib0h	861	5	protein	protein	NN
cord-021419-nypnib0h	861	6	kinase	kinase	NN
cord-021419-nypnib0h	861	7	is	be	VBZ
cord-021419-nypnib0h	861	8	one	one	CD
cord-021419-nypnib0h	861	9	of	of	IN
cord-021419-nypnib0h	861	10	possible	possible	JJ
cord-021419-nypnib0h	861	11	targets	target	NNS
cord-021419-nypnib0h	861	12	for	for	IN
cord-021419-nypnib0h	861	13	this	this	DT
cord-021419-nypnib0h	861	14	agluco	agluco	VBN
cord-021419-nypnib0h	861	15	analogue	analogue	NN
cord-021419-nypnib0h	861	16	,	,	,
cord-021419-nypnib0h	861	17	because	because	IN
cord-021419-nypnib0h	861	18	antiviral	antiviral	JJ
cord-021419-nypnib0h	861	19	activity	activity	NN
cord-021419-nypnib0h	861	20	was	be	VBD
cord-021419-nypnib0h	861	21	shown	show	VBN
cord-021419-nypnib0h	861	22	to	to	TO
cord-021419-nypnib0h	861	23	correlate	correlate	VB
cord-021419-nypnib0h	861	24	with	with	IN
cord-021419-nypnib0h	861	25	the	the	DT
cord-021419-nypnib0h	861	26	inhibition	inhibition	NN
cord-021419-nypnib0h	861	27	of	of	IN
cord-021419-nypnib0h	861	28	serine/	serine/	CD
cord-021419-nypnib0h	861	29	threonine	threonine	NN
cord-021419-nypnib0h	861	30	protein	protein	NN
cord-021419-nypnib0h	861	31	kinases	kinase	NNS
cord-021419-nypnib0h	861	32	.	.	.
cord-021419-nypnib0h	862	1	27	27	CD
cord-021419-nypnib0h	863	1	Comprehensive	comprehensive	JJ
cord-021419-nypnib0h	863	2	research	research	NN
cord-021419-nypnib0h	863	3	on	on	IN
cord-021419-nypnib0h	863	4	the	the	DT
cord-021419-nypnib0h	863	5	synthesis	synthesis	NN
cord-021419-nypnib0h	863	6	and	and	CC
cord-021419-nypnib0h	863	7	characterization	characterization	NN
cord-021419-nypnib0h	863	8	of	of	IN
cord-021419-nypnib0h	863	9	heterodimeric	heterodimeric	NNP
cord-021419-nypnib0h	863	10	conjugates	conjugate	NNS
cord-021419-nypnib0h	863	11	based	base	VBN
cord-021419-nypnib0h	863	12	on	on	IN
cord-021419-nypnib0h	863	13	different	different	JJ
cord-021419-nypnib0h	863	14	classes	class	NNS
cord-021419-nypnib0h	863	15	of	of	IN
cord-021419-nypnib0h	863	16	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	863	17	was	be	VBD
cord-021419-nypnib0h	863	18	initiated	initiate	VBN
cord-021419-nypnib0h	863	19	in	in	IN
cord-021419-nypnib0h	863	20	the	the	DT
cord-021419-nypnib0h	863	21	Gause	Gause	NNP
cord-021419-nypnib0h	863	22	Institute	Institute	NNP
cord-021419-nypnib0h	863	23	of	of	IN
cord-021419-nypnib0h	863	24	New	New	NNP
cord-021419-nypnib0h	863	25	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	863	26	under	under	IN
cord-021419-nypnib0h	863	27	the	the	DT
cord-021419-nypnib0h	863	28	supervision	supervision	NN
cord-021419-nypnib0h	863	29	of	of	IN
cord-021419-nypnib0h	863	30	Professor	Professor	NNP
cord-021419-nypnib0h	863	31	M.N.Preobrazhenskaya	M.N.Preobrazhenskaya	NNP
cord-021419-nypnib0h	863	32	.	.	.
cord-021419-nypnib0h	864	1	The	the	DT
cord-021419-nypnib0h	864	2	following	follow	VBG
cord-021419-nypnib0h	864	3	hybrid	hybrid	NN
cord-021419-nypnib0h	864	4	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	864	5	were	be	VBD
cord-021419-nypnib0h	864	6	synthesized	synthesize	VBN
cord-021419-nypnib0h	864	7	:	:	:
cord-021419-nypnib0h	864	8	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	864	9	±	±	NNP
cord-021419-nypnib0h	865	1	macrolide	macrolide	NNP
cord-021419-nypnib0h	865	2	,	,	,
cord-021419-nypnib0h	865	3	glycopeptide	glycopeptide	NNP
cord-021419-nypnib0h	865	4	±	±	NNP
cord-021419-nypnib0h	865	5	aminoglycoside	aminoglycoside	NN
cord-021419-nypnib0h	865	6	and	and	CC
cord-021419-nypnib0h	865	7	hybrid	hybrid	JJ
cord-021419-nypnib0h	865	8	compounds	compound	NNS
cord-021419-nypnib0h	865	9	containing	contain	VBG
cord-021419-nypnib0h	865	10	the	the	DT
cord-021419-nypnib0h	865	11	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	865	12	chromophore	chromophore	NN
cord-021419-nypnib0h	865	13	.	.	.
cord-021419-nypnib0h	866	1	The	the	DT
cord-021419-nypnib0h	866	2	literature	literature	NN
cord-021419-nypnib0h	866	3	data	datum	NNS
cord-021419-nypnib0h	866	4	provide	provide	VBP
cord-021419-nypnib0h	866	5	evidence	evidence	NN
cord-021419-nypnib0h	866	6	that	that	IN
cord-021419-nypnib0h	866	7	this	this	DT
cord-021419-nypnib0h	866	8	line	line	NN
cord-021419-nypnib0h	866	9	of	of	IN
cord-021419-nypnib0h	866	10	research	research	NN
cord-021419-nypnib0h	866	11	holds	hold	VBZ
cord-021419-nypnib0h	866	12	promise	promise	NN
cord-021419-nypnib0h	866	13	.	.	.
cord-021419-nypnib0h	867	1	28	28	CD
cord-021419-nypnib0h	867	2	,	,	,
cord-021419-nypnib0h	867	3	29	29	CD
cord-021419-nypnib0h	867	4	Macrolides	macrolide	NNS
cord-021419-nypnib0h	867	5	modified	modify	VBN
cord-021419-nypnib0h	867	6	through	through	IN
cord-021419-nypnib0h	867	7	the	the	DT
cord-021419-nypnib0h	867	8	carbamoyl	carbamoyl	NNP
cord-021419-nypnib0h	867	9	group	group	NN
cord-021419-nypnib0h	867	10	at	at	IN
cord-021419-nypnib0h	867	11	the	the	DT
cord-021419-nypnib0h	867	12	4	4	CD
cord-021419-nypnib0h	867	13	HH	HH	NNP
cord-021419-nypnib0h	867	14	position	position	NN
cord-021419-nypnib0h	867	15	can	can	MD
cord-021419-nypnib0h	867	16	acquire	acquire	VB
cord-021419-nypnib0h	867	17	activity	activity	NN
cord-021419-nypnib0h	867	18	against	against	IN
cord-021419-nypnib0h	867	19	drug	drug	NN
cord-021419-nypnib0h	867	20	-	-	HYPH
cord-021419-nypnib0h	867	21	resistant	resistant	JJ
cord-021419-nypnib0h	867	22	bacterial	bacterial	JJ
cord-021419-nypnib0h	867	23	cell	cell	NN
cord-021419-nypnib0h	867	24	lines	line	NNS
cord-021419-nypnib0h	867	25	.	.	.
cord-021419-nypnib0h	868	1	Generally	generally	RB
cord-021419-nypnib0h	868	2	,	,	,
cord-021419-nypnib0h	868	3	conjugates	conjugate	NNS
cord-021419-nypnib0h	868	4	containing	contain	VBG
cord-021419-nypnib0h	868	5	a	a	DT
cord-021419-nypnib0h	868	6	long	long	JJ
cord-021419-nypnib0h	868	7	spacer	spacer	NN
cord-021419-nypnib0h	868	8	exhibit	exhibit	NN
cord-021419-nypnib0h	868	9	higher	high	JJR
cord-021419-nypnib0h	868	10	activity	activity	NN
cord-021419-nypnib0h	868	11	than	than	IN
cord-021419-nypnib0h	868	12	the	the	DT
cord-021419-nypnib0h	868	13	related	related	JJ
cord-021419-nypnib0h	868	14	compounds	compound	NNS
cord-021419-nypnib0h	868	15	with	with	IN
cord-021419-nypnib0h	868	16	a	a	DT
cord-021419-nypnib0h	868	17	shorter	short	JJR
cord-021419-nypnib0h	868	18	spacer	spacer	NN
cord-021419-nypnib0h	868	19	.	.	.
cord-021419-nypnib0h	869	1	40	40	CD
cord-021419-nypnib0h	869	2	,	,	,
cord-021419-nypnib0h	869	3	41	41	CD
cord-021419-nypnib0h	869	4	Investigations	investigation	NNS
cord-021419-nypnib0h	869	5	of	of	IN
cord-021419-nypnib0h	869	6	interactions	interaction	NNS
cord-021419-nypnib0h	869	7	between	between	IN
cord-021419-nypnib0h	869	8	different	different	JJ
cord-021419-nypnib0h	869	9	benzoxaboroles	benzoxaborole	NNS
cord-021419-nypnib0h	869	10	and	and	CC
cord-021419-nypnib0h	869	11	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	869	12	made	make	VBD
cord-021419-nypnib0h	869	13	a	a	DT
cord-021419-nypnib0h	869	14	significant	significant	JJ
cord-021419-nypnib0h	869	15	contribution	contribution	NN
cord-021419-nypnib0h	869	16	to	to	IN
cord-021419-nypnib0h	869	17	the	the	DT
cord-021419-nypnib0h	869	18	chemistry	chemistry	NN
cord-021419-nypnib0h	869	19	of	of	IN
cord-021419-nypnib0h	869	20	not	not	RB
cord-021419-nypnib0h	869	21	only	only	RB
cord-021419-nypnib0h	869	22	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	869	23	with	with	IN
cord-021419-nypnib0h	869	24	complex	complex	JJ
cord-021419-nypnib0h	869	25	structures	structure	NNS
cord-021419-nypnib0h	869	26	but	but	CC
cord-021419-nypnib0h	869	27	also	also	RB
cord-021419-nypnib0h	869	28	the	the	DT
cord-021419-nypnib0h	869	29	relatively	relatively	RB
cord-021419-nypnib0h	869	30	poorly	poorly	RB
cord-021419-nypnib0h	869	31	studied	study	VBN
cord-021419-nypnib0h	869	32	borole	borole	NN
cord-021419-nypnib0h	869	33	compounds	compound	NNS
cord-021419-nypnib0h	869	34	.	.	.
cord-021419-nypnib0h	870	1	Benzoxaboroles	Benzoxaboroles	NNP
cord-021419-nypnib0h	870	2	were	be	VBD
cord-021419-nypnib0h	870	3	found	find	VBN
cord-021419-nypnib0h	870	4	to	to	TO
cord-021419-nypnib0h	870	5	be	be	VB
cord-021419-nypnib0h	870	6	quite	quite	RB
cord-021419-nypnib0h	870	7	stable	stable	JJ
cord-021419-nypnib0h	870	8	under	under	IN
cord-021419-nypnib0h	870	9	different	different	JJ
cord-021419-nypnib0h	870	10	reaction	reaction	NN
cord-021419-nypnib0h	870	11	conditions	condition	NNS
cord-021419-nypnib0h	870	12	.	.	.
cord-021419-nypnib0h	871	1	In	in	IN
cord-021419-nypnib0h	871	2	particular	particular	JJ
cord-021419-nypnib0h	871	3	,	,	,
cord-021419-nypnib0h	871	4	the	the	DT
cord-021419-nypnib0h	871	5	acylation	acylation	NN
cord-021419-nypnib0h	871	6	,	,	,
cord-021419-nypnib0h	871	7	amidation	amidation	NN
cord-021419-nypnib0h	871	8	and	and	CC
cord-021419-nypnib0h	871	9	reductive	reductive	JJ
cord-021419-nypnib0h	871	10	alkylation	alkylation	NN
cord-021419-nypnib0h	871	11	with	with	IN
cord-021419-nypnib0h	871	12	reactive	reactive	JJ
cord-021419-nypnib0h	871	13	agents	agent	NNS
cord-021419-nypnib0h	871	14	and	and	CC
cord-021419-nypnib0h	871	15	on	on	IN
cord-021419-nypnib0h	871	16	heating	heating	NN
cord-021419-nypnib0h	871	17	are	be	VBP
cord-021419-nypnib0h	871	18	virtually	virtually	RB
cord-021419-nypnib0h	871	19	not	not	RB
cord-021419-nypnib0h	871	20	accompanied	accompany	VBN
cord-021419-nypnib0h	871	21	by	by	IN
cord-021419-nypnib0h	871	22	oxaborole	oxaborole	NNP
cord-021419-nypnib0h	871	23	ring	ring	NN
cord-021419-nypnib0h	871	24	opening	opening	NN
cord-021419-nypnib0h	871	25	.	.	.
cord-021419-nypnib0h	872	1	32	32	CD
cord-021419-nypnib0h	873	1	The	the	DT
cord-021419-nypnib0h	873	2	introduction	introduction	NN
cord-021419-nypnib0h	873	3	of	of	IN
cord-021419-nypnib0h	873	4	the	the	DT
cord-021419-nypnib0h	873	5	benzoxaborole	benzoxaborole	NNP
cord-021419-nypnib0h	873	6	substituent	substituent	VBZ
cord-021419-nypnib0h	873	7	into	into	IN
cord-021419-nypnib0h	873	8	the	the	DT
cord-021419-nypnib0h	873	9	polyene	polyene	NNP
cord-021419-nypnib0h	873	10	macrolide	macrolide	NN
cord-021419-nypnib0h	873	11	amphotericin	amphotericin	NNP
cord-021419-nypnib0h	873	12	B	B	NNP
cord-021419-nypnib0h	873	13	(	(	-LRB-
cord-021419-nypnib0h	873	14	AmB	AmB	NNP
cord-021419-nypnib0h	873	15	)	)	-RRB-
cord-021419-nypnib0h	873	16	also	also	RB
cord-021419-nypnib0h	873	17	enhances	enhance	VBZ
cord-021419-nypnib0h	873	18	biological	biological	JJ
cord-021419-nypnib0h	873	19	activity	activity	NN
cord-021419-nypnib0h	873	20	.	.	.
cord-021419-nypnib0h	874	1	The	the	DT
cord-021419-nypnib0h	874	2	resulting	result	VBG
cord-021419-nypnib0h	874	3	compounds	compound	NNS
cord-021419-nypnib0h	874	4	possess	possess	VBP
cord-021419-nypnib0h	874	5	valuable	valuable	JJ
cord-021419-nypnib0h	874	6	properties	property	NNS
cord-021419-nypnib0h	874	7	,	,	,
cord-021419-nypnib0h	874	8	such	such	JJ
cord-021419-nypnib0h	874	9	as	as	IN
cord-021419-nypnib0h	874	10	lower	low	JJR
cord-021419-nypnib0h	874	11	cytotoxic	cytotoxic	JJ
cord-021419-nypnib0h	874	12	and	and	CC
cord-021419-nypnib0h	874	13	haemolytic	haemolytic	JJ
cord-021419-nypnib0h	874	14	activity	activity	NN
cord-021419-nypnib0h	874	15	compared	compare	VBN
cord-021419-nypnib0h	874	16	to	to	IN
cord-021419-nypnib0h	874	17	AmB	amb	NN
cord-021419-nypnib0h	874	18	combined	combine	VBN
cord-021419-nypnib0h	874	19	with	with	IN
cord-021419-nypnib0h	874	20	high	high	JJ
cord-021419-nypnib0h	874	21	antifungal	antifungal	JJ
cord-021419-nypnib0h	874	22	activity	activity	NN
cord-021419-nypnib0h	874	23	.	.	.
cord-021419-nypnib0h	875	1	52	52	CD
cord-021419-nypnib0h	876	1	The	the	DT
cord-021419-nypnib0h	876	2	efficiency	efficiency	NN
cord-021419-nypnib0h	876	3	of	of	IN
cord-021419-nypnib0h	876	4	the	the	DT
cord-021419-nypnib0h	876	5	approach	approach	NN
cord-021419-nypnib0h	876	6	to	to	IN
cord-021419-nypnib0h	876	7	the	the	DT
cord-021419-nypnib0h	876	8	design	design	NN
cord-021419-nypnib0h	876	9	of	of	IN
cord-021419-nypnib0h	876	10	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	876	11	of	of	IN
cord-021419-nypnib0h	876	12	a	a	DT
cord-021419-nypnib0h	876	13	new	new	JJ
cord-021419-nypnib0h	876	14	generation	generation	NN
cord-021419-nypnib0h	876	15	was	be	VBD
cord-021419-nypnib0h	876	16	demonstrated	demonstrate	VBN
cord-021419-nypnib0h	876	17	in	in	IN
cord-021419-nypnib0h	876	18	relation	relation	NN
cord-021419-nypnib0h	876	19	to	to	IN
cord-021419-nypnib0h	876	20	antifungal	antifungal	JJ
cord-021419-nypnib0h	876	21	polyene	polyene	NNP
cord-021419-nypnib0h	876	22	macrolides	macrolide	NNS
cord-021419-nypnib0h	876	23	.	.	.
cord-021419-nypnib0h	877	1	It	-PRON-	PRP
cord-021419-nypnib0h	877	2	is	be	VBZ
cord-021419-nypnib0h	877	3	based	base	VBN
cord-021419-nypnib0h	877	4	on	on	IN
cord-021419-nypnib0h	877	5	a	a	DT
cord-021419-nypnib0h	877	6	combination	combination	NN
cord-021419-nypnib0h	877	7	of	of	IN
cord-021419-nypnib0h	877	8	genetic	genetic	JJ
cord-021419-nypnib0h	877	9	engineering	engineering	NN
cord-021419-nypnib0h	877	10	techniques	technique	NNS
cord-021419-nypnib0h	877	11	and	and	CC
cord-021419-nypnib0h	877	12	methods	method	NNS
cord-021419-nypnib0h	877	13	of	of	IN
cord-021419-nypnib0h	877	14	organic	organic	JJ
cord-021419-nypnib0h	877	15	synthesis	synthesis	NN
cord-021419-nypnib0h	877	16	48	48	CD
cord-021419-nypnib0h	877	17	±	±	CD
cord-021419-nypnib0h	877	18	50	50	CD
cord-021419-nypnib0h	877	19	and	and	CC
cord-021419-nypnib0h	877	20	is	be	VBZ
cord-021419-nypnib0h	877	21	protected	protect	VBN
cord-021419-nypnib0h	877	22	by	by	IN
cord-021419-nypnib0h	877	23	an	an	DT
cord-021419-nypnib0h	877	24	international	international	JJ
cord-021419-nypnib0h	877	25	patent	patent	NN
cord-021419-nypnib0h	877	26	.	.	.
cord-021419-nypnib0h	878	1	46	46	CD
cord-021419-nypnib0h	879	1	The	the	DT
cord-021419-nypnib0h	879	2	chemical	chemical	JJ
cord-021419-nypnib0h	879	3	modification	modification	NN
cord-021419-nypnib0h	879	4	of	of	IN
cord-021419-nypnib0h	879	5	polyene	polyene	NNP
cord-021419-nypnib0h	879	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	879	7	,	,	,
cord-021419-nypnib0h	879	8	which	which	WDT
cord-021419-nypnib0h	879	9	were	be	VBD
cord-021419-nypnib0h	879	10	obtained	obtain	VBN
cord-021419-nypnib0h	879	11	via	via	IN
cord-021419-nypnib0h	879	12	the	the	DT
cord-021419-nypnib0h	879	13	genetic	genetic	JJ
cord-021419-nypnib0h	879	14	engineering	engineering	NN
cord-021419-nypnib0h	879	15	of	of	IN
cord-021419-nypnib0h	879	16	nystatin	nystatin	NNP
cord-021419-nypnib0h	879	17	A1	A1	NNP
cord-021419-nypnib0h	879	18	biosynthesis	biosynthesis	NN
cord-021419-nypnib0h	879	19	at	at	IN
cord-021419-nypnib0h	879	20	the	the	DT
cord-021419-nypnib0h	879	21	Norwegian	Norwegian	NNP
cord-021419-nypnib0h	879	22	University	University	NNP
cord-021419-nypnib0h	879	23	,	,	,
cord-021419-nypnib0h	879	24	gave	give	VBD
cord-021419-nypnib0h	879	25	a	a	DT
cord-021419-nypnib0h	879	26	series	series	NN
cord-021419-nypnib0h	879	27	of	of	IN
cord-021419-nypnib0h	879	28	agents	agent	NNS
cord-021419-nypnib0h	879	29	exhibiting	exhibit	VBG
cord-021419-nypnib0h	879	30	lower	low	JJR
cord-021419-nypnib0h	879	31	toxicity	toxicity	NN
cord-021419-nypnib0h	879	32	and	and	CC
cord-021419-nypnib0h	879	33	higher	high	JJR
cord-021419-nypnib0h	879	34	activity	activity	NN
cord-021419-nypnib0h	879	35	compared	compare	VBN
cord-021419-nypnib0h	879	36	to	to	IN
cord-021419-nypnib0h	879	37	amphotericin	amphotericin	NNS
cord-021419-nypnib0h	879	38	B	b	NN
cord-021419-nypnib0h	879	39	in	in	IN
cord-021419-nypnib0h	879	40	animal	animal	NN
cord-021419-nypnib0h	879	41	assays	assay	NNS
cord-021419-nypnib0h	879	42	.	.	.
cord-021419-nypnib0h	880	1	The	the	DT
cord-021419-nypnib0h	880	2	dependence	dependence	NN
cord-021419-nypnib0h	880	3	of	of	IN
cord-021419-nypnib0h	880	4	antifungal	antifungal	JJ
cord-021419-nypnib0h	880	5	activity	activity	NN
cord-021419-nypnib0h	880	6	on	on	IN
cord-021419-nypnib0h	880	7	the	the	DT
cord-021419-nypnib0h	880	8	structure	structure	NN
cord-021419-nypnib0h	880	9	of	of	IN
cord-021419-nypnib0h	880	10	the	the	DT
cord-021419-nypnib0h	880	11	polyol	polyol	JJ
cord-021419-nypnib0h	880	12	region	region	NN
cord-021419-nypnib0h	880	13	[	[	-LRB-
cord-021419-nypnib0h	880	14	C(7	C(7	NNP
cord-021419-nypnib0h	880	15	)	)	-RRB-
cord-021419-nypnib0h	880	16	±	±	NNP
cord-021419-nypnib0h	880	17	C(10	C(10	NNP
cord-021419-nypnib0h	880	18	)	)	-RRB-
cord-021419-nypnib0h	880	19	]	]	-RRB-
cord-021419-nypnib0h	880	20	of	of	IN
cord-021419-nypnib0h	880	21	these	these	DT
cord-021419-nypnib0h	880	22	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	880	23	was	be	VBD
cord-021419-nypnib0h	880	24	revealed	reveal	VBN
cord-021419-nypnib0h	880	25	for	for	IN
cord-021419-nypnib0h	880	26	the	the	DT
cord-021419-nypnib0h	880	27	first	first	JJ
cord-021419-nypnib0h	880	28	time	time	NN
cord-021419-nypnib0h	880	29	by	by	IN
cord-021419-nypnib0h	880	30	Preobrazhenskaya	Preobrazhenskaya	NNP
cord-021419-nypnib0h	880	31	et	et	NNP
cord-021419-nypnib0h	880	32	al	al	NNP
cord-021419-nypnib0h	880	33	.	.	.
cord-021419-nypnib0h	881	1	49	49	CD
cord-021419-nypnib0h	881	2	Pioneering	pioneering	JJ
cord-021419-nypnib0h	881	3	studies	study	NNS
cord-021419-nypnib0h	881	4	on	on	IN
cord-021419-nypnib0h	881	5	the	the	DT
cord-021419-nypnib0h	881	6	development	development	NN
cord-021419-nypnib0h	881	7	of	of	IN
cord-021419-nypnib0h	881	8	methods	method	NNS
cord-021419-nypnib0h	881	9	for	for	IN
cord-021419-nypnib0h	881	10	selective	selective	JJ
cord-021419-nypnib0h	881	11	chemical	chemical	NN
cord-021419-nypnib0h	881	12	modification	modification	NN
cord-021419-nypnib0h	881	13	of	of	IN
cord-021419-nypnib0h	881	14	the	the	DT
cord-021419-nypnib0h	881	15	unique	unique	JJ
cord-021419-nypnib0h	881	16	macrolactone	macrolactone	NN
cord-021419-nypnib0h	881	17	oligomycin	oligomycin	NNP
cord-021419-nypnib0h	881	18	A	A	NNP
cord-021419-nypnib0h	881	19	,	,	,
cord-021419-nypnib0h	881	20	a	a	DT
cord-021419-nypnib0h	881	21	specific	specific	JJ
cord-021419-nypnib0h	881	22	F	f	NN
cord-021419-nypnib0h	881	23	0	0	CD
cord-021419-nypnib0h	881	24	F	F	NNP
cord-021419-nypnib0h	881	25	1	1	CD
cord-021419-nypnib0h	881	26	-ATP	-ATP	:
cord-021419-nypnib0h	881	27	synthase	synthase	NN
cord-021419-nypnib0h	881	28	inhibitor	inhibitor	NN
cord-021419-nypnib0h	881	29	,	,	,
cord-021419-nypnib0h	881	30	and	and	CC
cord-021419-nypnib0h	882	1	the	the	DT
cord-021419-nypnib0h	882	2	original	original	JJ
cord-021419-nypnib0h	882	3	antitumour	antitumour	NNP
cord-021419-nypnib0h	882	4	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	882	5	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	882	6	A	a	NN
cord-021419-nypnib0h	882	7	of	of	IN
cord-021419-nypnib0h	882	8	the	the	DT
cord-021419-nypnib0h	882	9	aureolic	aureolic	NNP
cord-021419-nypnib0h	882	10	acid	acid	NNP
cord-021419-nypnib0h	882	11	group	group	NNP
cord-021419-nypnib0h	882	12	were	be	VBD
cord-021419-nypnib0h	882	13	performed	perform	VBN
cord-021419-nypnib0h	882	14	.	.	.
cord-021419-nypnib0h	883	1	In	in	IN
cord-021419-nypnib0h	883	2	both	both	DT
cord-021419-nypnib0h	883	3	cases	case	NNS
cord-021419-nypnib0h	883	4	,	,	,
cord-021419-nypnib0h	883	5	examples	example	NNS
cord-021419-nypnib0h	883	6	of	of	IN
cord-021419-nypnib0h	883	7	chemical	chemical	JJ
cord-021419-nypnib0h	883	8	modifications	modification	NNS
cord-021419-nypnib0h	883	9	of	of	IN
cord-021419-nypnib0h	883	10	related	related	JJ
cord-021419-nypnib0h	883	11	compounds	compound	NNS
cord-021419-nypnib0h	883	12	for	for	IN
cord-021419-nypnib0h	883	13	these	these	DT
cord-021419-nypnib0h	883	14	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	883	15	are	be	VBP
cord-021419-nypnib0h	883	16	absent	absent	JJ
cord-021419-nypnib0h	883	17	in	in	IN
cord-021419-nypnib0h	883	18	the	the	DT
cord-021419-nypnib0h	883	19	literature	literature	NN
cord-021419-nypnib0h	883	20	.	.	.
cord-021419-nypnib0h	884	1	These	these	DT
cord-021419-nypnib0h	884	2	results	result	NNS
cord-021419-nypnib0h	884	3	are	be	VBP
cord-021419-nypnib0h	884	4	of	of	IN
cord-021419-nypnib0h	884	5	great	great	JJ
cord-021419-nypnib0h	884	6	scientific	scientific	JJ
cord-021419-nypnib0h	884	7	value	value	NN
cord-021419-nypnib0h	884	8	.	.	.
cord-021419-nypnib0h	885	1	Investigations	investigation	NNS
cord-021419-nypnib0h	885	2	of	of	IN
cord-021419-nypnib0h	885	3	F	F	NNP
cord-021419-nypnib0h	885	4	0	0	CD
cord-021419-nypnib0h	885	5	F	F	NNP
cord-021419-nypnib0h	885	6	1	1	CD
cord-021419-nypnib0h	885	7	-ATP	-ATP	:
cord-021419-nypnib0h	885	8	synthase	synthase	NN
cord-021419-nypnib0h	885	9	inhibitors	inhibitor	NNS
cord-021419-nypnib0h	885	10	are	be	VBP
cord-021419-nypnib0h	885	11	of	of	IN
cord-021419-nypnib0h	885	12	considerable	considerable	JJ
cord-021419-nypnib0h	885	13	interest	interest	NN
cord-021419-nypnib0h	885	14	because	because	IN
cord-021419-nypnib0h	885	15	this	this	DT
cord-021419-nypnib0h	885	16	enzyme	enzyme	NN
cord-021419-nypnib0h	885	17	is	be	VBZ
cord-021419-nypnib0h	885	18	involved	involve	VBN
cord-021419-nypnib0h	885	19	in	in	IN
cord-021419-nypnib0h	885	20	the	the	DT
cord-021419-nypnib0h	885	21	development	development	NN
cord-021419-nypnib0h	885	22	of	of	IN
cord-021419-nypnib0h	885	23	resistance	resistance	NN
cord-021419-nypnib0h	885	24	in	in	IN
cord-021419-nypnib0h	885	25	microorganisms	microorganism	NNS
cord-021419-nypnib0h	885	26	.	.	.
cord-021419-nypnib0h	886	1	Chemical	chemical	NN
cord-021419-nypnib0h	886	2	transformations	transformation	NNS
cord-021419-nypnib0h	886	3	of	of	IN
cord-021419-nypnib0h	886	4	oligomycin	oligomycin	NNS
cord-021419-nypnib0h	886	5	A	a	DT
cord-021419-nypnib0h	886	6	using	use	VBG
cord-021419-nypnib0h	886	7	different	different	JJ
cord-021419-nypnib0h	886	8	reagents	reagent	NNS
cord-021419-nypnib0h	886	9	were	be	VBD
cord-021419-nypnib0h	886	10	studied	study	VBN
cord-021419-nypnib0h	886	11	in	in	IN
cord-021419-nypnib0h	886	12	detail	detail	NN
cord-021419-nypnib0h	886	13	.	.	.
cord-021419-nypnib0h	887	1	Alkaline	alkaline	JJ
cord-021419-nypnib0h	887	2	hydrolysis	hydrolysis	NN
cord-021419-nypnib0h	887	3	reactions	reaction	NNS
cord-021419-nypnib0h	887	4	were	be	VBD
cord-021419-nypnib0h	887	5	performed	perform	VBN
cord-021419-nypnib0h	887	6	and	and	CC
cord-021419-nypnib0h	887	7	conditions	condition	NNS
cord-021419-nypnib0h	887	8	for	for	IN
cord-021419-nypnib0h	887	9	the	the	DT
cord-021419-nypnib0h	887	10	selective	selective	JJ
cord-021419-nypnib0h	887	11	reduction	reduction	NN
cord-021419-nypnib0h	887	12	of	of	IN
cord-021419-nypnib0h	887	13	double	double	JJ
cord-021419-nypnib0h	887	14	bonds	bond	NNS
cord-021419-nypnib0h	887	15	and	and	CC
cord-021419-nypnib0h	887	16	keto	keto	NNP
cord-021419-nypnib0h	887	17	groups	group	NNS
cord-021419-nypnib0h	887	18	,	,	,
cord-021419-nypnib0h	887	19	cyclization	cyclization	NN
cord-021419-nypnib0h	887	20	,	,	,
cord-021419-nypnib0h	887	21	etc	etc	FW
cord-021419-nypnib0h	887	22	.	.	NN
cord-021419-nypnib0h	887	23	were	be	VBD
cord-021419-nypnib0h	887	24	found	find	VBN
cord-021419-nypnib0h	887	25	.	.	.
cord-021419-nypnib0h	888	1	The	the	DT
cord-021419-nypnib0h	888	2	replacement	replacement	NN
cord-021419-nypnib0h	888	3	of	of	IN
cord-021419-nypnib0h	888	4	the	the	DT
cord-021419-nypnib0h	888	5	C(33)-hydroxyl	C(33)-hydroxyl	NNP
cord-021419-nypnib0h	888	6	group	group	NN
cord-021419-nypnib0h	888	7	by	by	IN
cord-021419-nypnib0h	888	8	the	the	DT
cord-021419-nypnib0h	888	9	activated	activate	VBN
cord-021419-nypnib0h	888	10	mesyl	mesyl	NNP
cord-021419-nypnib0h	888	11	group	group	NNP
cord-021419-nypnib0h	888	12	has	have	VBZ
cord-021419-nypnib0h	888	13	proved	prove	VBN
cord-021419-nypnib0h	888	14	to	to	TO
cord-021419-nypnib0h	888	15	be	be	VB
cord-021419-nypnib0h	888	16	particularly	particularly	RB
cord-021419-nypnib0h	888	17	successful	successful	JJ
cord-021419-nypnib0h	888	18	.	.	.
cord-021419-nypnib0h	889	1	55	55	CD
cord-021419-nypnib0h	890	1	This	this	DT
cord-021419-nypnib0h	890	2	modification	modification	NN
cord-021419-nypnib0h	890	3	has	have	VBZ
cord-021419-nypnib0h	890	4	no	no	DT
cord-021419-nypnib0h	890	5	significant	significant	JJ
cord-021419-nypnib0h	890	6	effect	effect	NN
cord-021419-nypnib0h	890	7	on	on	IN
cord-021419-nypnib0h	890	8	biological	biological	JJ
cord-021419-nypnib0h	890	9	activity	activity	NN
cord-021419-nypnib0h	890	10	of	of	IN
cord-021419-nypnib0h	890	11	the	the	DT
cord-021419-nypnib0h	890	12	antibiotic	antibiotic	NN
cord-021419-nypnib0h	890	13	but	but	CC
cord-021419-nypnib0h	890	14	provides	provide	VBZ
cord-021419-nypnib0h	890	15	a	a	DT
cord-021419-nypnib0h	890	16	possibility	possibility	NN
cord-021419-nypnib0h	890	17	to	to	TO
cord-021419-nypnib0h	890	18	optimize	optimize	VB
cord-021419-nypnib0h	890	19	its	-PRON-	PRP$
cord-021419-nypnib0h	890	20	pharmacological	pharmacological	JJ
cord-021419-nypnib0h	890	21	properties	property	NNS
cord-021419-nypnib0h	890	22	.	.	.
cord-021419-nypnib0h	891	1	65	65	CD
cord-021419-nypnib0h	891	2	,	,	,
cord-021419-nypnib0h	891	3	67	67	CD
cord-021419-nypnib0h	891	4	Only	only	JJ
cord-021419-nypnib0h	891	5	transformations	transformation	NNS
cord-021419-nypnib0h	891	6	via	via	IN
cord-021419-nypnib0h	891	7	the	the	DT
cord-021419-nypnib0h	891	8	biosynthesis	biosynthesis	NN
cord-021419-nypnib0h	891	9	were	be	VBD
cord-021419-nypnib0h	891	10	described	describe	VBN
cord-021419-nypnib0h	891	11	for	for	IN
cord-021419-nypnib0h	891	12	the	the	DT
cord-021419-nypnib0h	891	13	aureolic	aureolic	NNP
cord-021419-nypnib0h	891	14	acid	acid	NNP
cord-021419-nypnib0h	891	15	group	group	NN
cord-021419-nypnib0h	891	16	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	891	17	mithramycin	mithramycin	NNPS
cord-021419-nypnib0h	891	18	and	and	CC
cord-021419-nypnib0h	891	19	chromomycin	chromomycin	NNS
cord-021419-nypnib0h	891	20	.	.	.
cord-021419-nypnib0h	892	1	70	70	CD
cord-021419-nypnib0h	892	2	,	,	,
cord-021419-nypnib0h	892	3	76	76	CD
cord-021419-nypnib0h	893	1	These	these	DT
cord-021419-nypnib0h	893	2	natural	natural	JJ
cord-021419-nypnib0h	893	3	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	893	4	,	,	,
cord-021419-nypnib0h	893	5	which	which	WDT
cord-021419-nypnib0h	893	6	have	have	VBP
cord-021419-nypnib0h	893	7	a	a	DT
cord-021419-nypnib0h	893	8	limited	limited	JJ
cord-021419-nypnib0h	893	9	use	use	NN
cord-021419-nypnib0h	893	10	in	in	IN
cord-021419-nypnib0h	893	11	the	the	DT
cord-021419-nypnib0h	893	12	treatment	treatment	NN
cord-021419-nypnib0h	893	13	of	of	IN
cord-021419-nypnib0h	893	14	some	some	DT
cord-021419-nypnib0h	893	15	malignant	malignant	JJ
cord-021419-nypnib0h	893	16	tumours	tumour	NNS
cord-021419-nypnib0h	893	17	,	,	,
cord-021419-nypnib0h	893	18	have	have	VBP
cord-021419-nypnib0h	893	19	attracted	attract	VBN
cord-021419-nypnib0h	893	20	increasing	increase	VBG
cord-021419-nypnib0h	893	21	attention	attention	NN
cord-021419-nypnib0h	893	22	of	of	IN
cord-021419-nypnib0h	893	23	researchers	researcher	NNS
cord-021419-nypnib0h	893	24	in	in	IN
cord-021419-nypnib0h	893	25	different	different	JJ
cord-021419-nypnib0h	893	26	fields	field	NNS
cord-021419-nypnib0h	893	27	.	.	.
cord-021419-nypnib0h	894	1	71	71	CD
cord-021419-nypnib0h	894	2	,	,	,
cord-021419-nypnib0h	894	3	73	73	CD
cord-021419-nypnib0h	895	1	The	the	DT
cord-021419-nypnib0h	895	2	synthesized	synthesize	VBN
cord-021419-nypnib0h	895	3	compounds	compound	NNS
cord-021419-nypnib0h	895	4	were	be	VBD
cord-021419-nypnib0h	895	5	tested	test	VBN
cord-021419-nypnib0h	895	6	for	for	IN
cord-021419-nypnib0h	895	7	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	895	8	activity	activity	NN
cord-021419-nypnib0h	895	9	.	.	.
cord-021419-nypnib0h	896	1	Based	base	VBN
cord-021419-nypnib0h	896	2	on	on	IN
cord-021419-nypnib0h	896	3	the	the	DT
cord-021419-nypnib0h	896	4	results	result	NNS
cord-021419-nypnib0h	896	5	of	of	IN
cord-021419-nypnib0h	896	6	in	in	FW
cord-021419-nypnib0h	896	7	vitro	vitro	FW
cord-021419-nypnib0h	896	8	studies	study	NNS
cord-021419-nypnib0h	896	9	of	of	IN
cord-021419-nypnib0h	896	10	a	a	DT
cord-021419-nypnib0h	896	11	series	series	NN
cord-021419-nypnib0h	896	12	of	of	IN
cord-021419-nypnib0h	896	13	new	new	JJ
cord-021419-nypnib0h	896	14	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	896	15	A	a	DT
cord-021419-nypnib0h	896	16	analogues	analogue	NNS
cord-021419-nypnib0h	896	17	of	of	IN
cord-021419-nypnib0h	896	18	different	different	JJ
cord-021419-nypnib0h	896	19	types	type	NNS
cord-021419-nypnib0h	896	20	,	,	,
cord-021419-nypnib0h	896	21	compounds	compound	NNS
cord-021419-nypnib0h	896	22	were	be	VBD
cord-021419-nypnib0h	896	23	selected	select	VBN
cord-021419-nypnib0h	896	24	for	for	IN
cord-021419-nypnib0h	896	25	the	the	DT
cord-021419-nypnib0h	896	26	in	in	IN
cord-021419-nypnib0h	896	27	vivo	vivo	NN
cord-021419-nypnib0h	896	28	evaluation	evaluation	NN
cord-021419-nypnib0h	896	29	.	.	.
cord-021419-nypnib0h	897	1	After	after	IN
cord-021419-nypnib0h	897	2	preclinical	preclinical	JJ
cord-021419-nypnib0h	897	3	trials	trial	NNS
cord-021419-nypnib0h	897	4	in	in	IN
cord-021419-nypnib0h	897	5	laboratory	laboratory	NN
cord-021419-nypnib0h	897	6	animals	animal	NNS
cord-021419-nypnib0h	897	7	(	(	-LRB-
cord-021419-nypnib0h	897	8	evaluatrion	evaluatrion	NN
cord-021419-nypnib0h	897	9	of	of	IN
cord-021419-nypnib0h	897	10	antitumour	antitumour	JJ
cord-021419-nypnib0h	897	11	activity	activity	NN
cord-021419-nypnib0h	897	12	and	and	CC
cord-021419-nypnib0h	897	13	toxicity	toxicity	NN
cord-021419-nypnib0h	897	14	)	)	-RRB-
cord-021419-nypnib0h	897	15	,	,	,
cord-021419-nypnib0h	897	16	one	one	CD
cord-021419-nypnib0h	897	17	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	897	18	A	a	DT
cord-021419-nypnib0h	897	19	analogue	analogue	NN
cord-021419-nypnib0h	897	20	was	be	VBD
cord-021419-nypnib0h	897	21	recommended	recommend	VBN
cord-021419-nypnib0h	897	22	for	for	IN
cord-021419-nypnib0h	897	23	further	further	JJ
cord-021419-nypnib0h	897	24	clinical	clinical	JJ
cord-021419-nypnib0h	897	25	trials	trial	NNS
cord-021419-nypnib0h	897	26	.	.	.
cord-021419-nypnib0h	898	1	87	87	CD
cord-021419-nypnib0h	898	2	±	±	CD
cord-021419-nypnib0h	898	3	89	89	CD
cord-021419-nypnib0h	898	4	A	a	DT
cord-021419-nypnib0h	898	5	systemic	systemic	JJ
cord-021419-nypnib0h	898	6	approach	approach	NN
cord-021419-nypnib0h	898	7	applied	apply	VBN
cord-021419-nypnib0h	898	8	to	to	IN
cord-021419-nypnib0h	898	9	series	series	NN
cord-021419-nypnib0h	898	10	of	of	IN
cord-021419-nypnib0h	898	11	new	new	JJ
cord-021419-nypnib0h	898	12	semisynthetic	semisynthetic	JJ
cord-021419-nypnib0h	898	13	analogues	analogue	NNS
cord-021419-nypnib0h	898	14	of	of	IN
cord-021419-nypnib0h	898	15	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	898	16	A	A	NNP
cord-021419-nypnib0h	898	17	allows	allow	VBZ
cord-021419-nypnib0h	898	18	a	a	DT
cord-021419-nypnib0h	898	19	detailed	detailed	JJ
cord-021419-nypnib0h	898	20	study	study	NN
cord-021419-nypnib0h	898	21	of	of	IN
cord-021419-nypnib0h	898	22	the	the	DT
cord-021419-nypnib0h	898	23	molecular	molecular	JJ
cord-021419-nypnib0h	898	24	mechanism	mechanism	NN
cord-021419-nypnib0h	898	25	of	of	IN
cord-021419-nypnib0h	898	26	antitumour	antitumour	JJ
cord-021419-nypnib0h	898	27	action	action	NN
cord-021419-nypnib0h	898	28	of	of	IN
cord-021419-nypnib0h	898	29	this	this	DT
cord-021419-nypnib0h	898	30	antibiotic	antibiotic	NN
cord-021419-nypnib0h	898	31	.	.	.
cord-021419-nypnib0h	899	1	79	79	CD
cord-021419-nypnib0h	899	2	±	±	CD
cord-021419-nypnib0h	899	3	81	81	CD
cord-021419-nypnib0h	900	1	In	in	IN
cord-021419-nypnib0h	900	2	particular	particular	JJ
cord-021419-nypnib0h	900	3	,	,	,
cord-021419-nypnib0h	900	4	it	-PRON-	PRP
cord-021419-nypnib0h	900	5	was	be	VBD
cord-021419-nypnib0h	900	6	shown	show	VBN
cord-021419-nypnib0h	900	7	that	that	IN
cord-021419-nypnib0h	900	8	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	900	9	and	and	CC
cord-021419-nypnib0h	900	10	its	-PRON-	PRP$
cord-021419-nypnib0h	900	11	analogues	analogue	NNS
cord-021419-nypnib0h	900	12	,	,	,
cord-021419-nypnib0h	900	13	acting	act	VBG
cord-021419-nypnib0h	900	14	as	as	IN
cord-021419-nypnib0h	900	15	DNA	dna	NN
cord-021419-nypnib0h	900	16	duplex	duplex	JJ
cord-021419-nypnib0h	900	17	minor	minor	JJ
cord-021419-nypnib0h	900	18	groove	groove	NN
cord-021419-nypnib0h	900	19	ligands	ligand	NNS
cord-021419-nypnib0h	900	20	,	,	,
cord-021419-nypnib0h	900	21	can	can	MD
cord-021419-nypnib0h	900	22	inhibit	inhibit	VB
cord-021419-nypnib0h	900	23	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	900	24	I	-PRON-	PRP
cord-021419-nypnib0h	900	25	and	and	CC
cord-021419-nypnib0h	900	26	the	the	DT
cord-021419-nypnib0h	900	27	Dnmt3a	Dnmt3a	NNP
cord-021419-nypnib0h	900	28	enzyme	enzyme	NN
cord-021419-nypnib0h	900	29	responsible	responsible	JJ
cord-021419-nypnib0h	900	30	for	for	IN
cord-021419-nypnib0h	900	31	the	the	DT
cord-021419-nypnib0h	900	32	disruption	disruption	NN
cord-021419-nypnib0h	900	33	of	of	IN
cord-021419-nypnib0h	900	34	the	the	DT
cord-021419-nypnib0h	900	35	key	key	JJ
cord-021419-nypnib0h	900	36	epigenetic	epigenetic	JJ
cord-021419-nypnib0h	900	37	DNA	dna	NN
cord-021419-nypnib0h	900	38	methylation	methylation	NN
cord-021419-nypnib0h	900	39	process	process	NN
cord-021419-nypnib0h	900	40	.	.	.
cord-021419-nypnib0h	901	1	79	79	CD
cord-021419-nypnib0h	901	2	,	,	,
cord-021419-nypnib0h	901	3	80	80	CD
cord-021419-nypnib0h	902	1	The	the	DT
cord-021419-nypnib0h	902	2	structural	structural	JJ
cord-021419-nypnib0h	902	3	fragments	fragment	NNS
cord-021419-nypnib0h	902	4	of	of	IN
cord-021419-nypnib0h	902	5	olivomycin	olivomycin	NNS
cord-021419-nypnib0h	902	6	A	A	NNP
cord-021419-nypnib0h	902	7	critical	critical	JJ
cord-021419-nypnib0h	902	8	for	for	IN
cord-021419-nypnib0h	902	9	antitumour	antitumour	JJ
cord-021419-nypnib0h	902	10	activity	activity	NN
cord-021419-nypnib0h	902	11	were	be	VBD
cord-021419-nypnib0h	902	12	identified	identify	VBN
cord-021419-nypnib0h	902	13	.	.	.
cord-021419-nypnib0h	903	1	A	a	DT
cord-021419-nypnib0h	903	2	model	model	NN
cord-021419-nypnib0h	903	3	of	of	IN
cord-021419-nypnib0h	903	4	the	the	DT
cord-021419-nypnib0h	903	5	interaction	interaction	NN
cord-021419-nypnib0h	903	6	of	of	IN
cord-021419-nypnib0h	903	7	the	the	DT
cord-021419-nypnib0h	903	8	antibiotic	antibiotic	JJ
cord-021419-nypnib0h	903	9	and	and	CC
cord-021419-nypnib0h	903	10	some	some	DT
cord-021419-nypnib0h	903	11	its	-PRON-	PRP$
cord-021419-nypnib0h	903	12	analogues	analogue	NNS
cord-021419-nypnib0h	903	13	with	with	IN
cord-021419-nypnib0h	903	14	the	the	DT
cord-021419-nypnib0h	903	15	DNA	DNA	NNP
cord-021419-nypnib0h	903	16	duplex	duplex	NN
cord-021419-nypnib0h	903	17	was	be	VBD
cord-021419-nypnib0h	903	18	proposed	propose	VBN
cord-021419-nypnib0h	903	19	.	.	.
cord-021419-nypnib0h	904	1	82	82	CD
cord-021419-nypnib0h	904	2	New	new	JJ
cord-021419-nypnib0h	904	3	analogues	analogue	NNS
cord-021419-nypnib0h	904	4	of	of	IN
cord-021419-nypnib0h	904	5	anthracycline	anthracycline	JJ
cord-021419-nypnib0h	904	6	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	904	7	with	with	IN
cord-021419-nypnib0h	904	8	substituents	substituent	NNS
cord-021419-nypnib0h	904	9	of	of	IN
cord-021419-nypnib0h	904	10	different	different	JJ
cord-021419-nypnib0h	904	11	types	type	NNS
cord-021419-nypnib0h	904	12	and	and	CC
cord-021419-nypnib0h	904	13	different	different	JJ
cord-021419-nypnib0h	904	14	length	length	NN
cord-021419-nypnib0h	904	15	,	,	,
cord-021419-nypnib0h	904	16	including	include	VBG
cord-021419-nypnib0h	904	17	those	those	DT
cord-021419-nypnib0h	904	18	containing	contain	VBG
cord-021419-nypnib0h	904	19	mono	mono	NN
cord-021419-nypnib0h	904	20	-	-	HYPH
cord-021419-nypnib0h	904	21	and	and	CC
cord-021419-nypnib0h	904	22	disaccharide	disaccharide	NN
cord-021419-nypnib0h	904	23	residues	residue	NNS
cord-021419-nypnib0h	904	24	,	,	,
cord-021419-nypnib0h	904	25	were	be	VBD
cord-021419-nypnib0h	904	26	prepared	prepare	VBN
cord-021419-nypnib0h	904	27	.	.	.
cord-021419-nypnib0h	905	1	The	the	DT
cord-021419-nypnib0h	905	2	evaluation	evaluation	NN
cord-021419-nypnib0h	905	3	of	of	IN
cord-021419-nypnib0h	905	4	the	the	DT
cord-021419-nypnib0h	905	5	effect	effect	NN
cord-021419-nypnib0h	905	6	of	of	IN
cord-021419-nypnib0h	905	7	polyhydroxylated	polyhydroxylated	JJ
cord-021419-nypnib0h	905	8	moieties	moiety	NNS
cord-021419-nypnib0h	905	9	of	of	IN
cord-021419-nypnib0h	905	10	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	905	11	and	and	CC
cord-021419-nypnib0h	905	12	14-hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	905	13	on	on	IN
cord-021419-nypnib0h	905	14	antitumour	antitumour	JJ
cord-021419-nypnib0h	905	15	activity	activity	NN
cord-021419-nypnib0h	905	16	showed	show	VBD
cord-021419-nypnib0h	905	17	that	that	IN
cord-021419-nypnib0h	905	18	this	this	DT
cord-021419-nypnib0h	905	19	modification	modification	NN
cord-021419-nypnib0h	905	20	does	do	VBZ
cord-021419-nypnib0h	905	21	not	not	RB
cord-021419-nypnib0h	905	22	lead	lead	VB
cord-021419-nypnib0h	905	23	to	to	IN
cord-021419-nypnib0h	905	24	the	the	DT
cord-021419-nypnib0h	905	25	loss	loss	NN
cord-021419-nypnib0h	905	26	of	of	IN
cord-021419-nypnib0h	905	27	activity	activity	NN
cord-021419-nypnib0h	905	28	of	of	IN
cord-021419-nypnib0h	905	29	anthracyclines	anthracycline	NNS
cord-021419-nypnib0h	905	30	93	93	CD
cord-021419-nypnib0h	905	31	±	±	CD
cord-021419-nypnib0h	905	32	95	95	CD
cord-021419-nypnib0h	905	33	and	and	CC
cord-021419-nypnib0h	905	34	enhances	enhance	VBZ
cord-021419-nypnib0h	905	35	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	905	36	activity	activity	NN
cord-021419-nypnib0h	905	37	against	against	IN
cord-021419-nypnib0h	905	38	topoisomerase	topoisomerase	NN
cord-021419-nypnib0h	905	39	I.	i.	NN
cord-021419-nypnib0h	905	40	92	92	CD
cord-021419-nypnib0h	905	41	14-Hydroxycarminomycin	14-hydroxycarminomycin	CD
cord-021419-nypnib0h	905	42	derivatives	derivative	NNS
cord-021419-nypnib0h	905	43	proved	prove	VBN
cord-021419-nypnib0h	905	44	to	to	TO
cord-021419-nypnib0h	905	45	be	be	VB
cord-021419-nypnib0h	905	46	particularly	particularly	RB
cord-021419-nypnib0h	905	47	valuable	valuable	JJ
cord-021419-nypnib0h	905	48	because	because	IN
cord-021419-nypnib0h	905	49	these	these	DT
cord-021419-nypnib0h	905	50	compounds	compound	NNS
cord-021419-nypnib0h	905	51	,	,	,
cord-021419-nypnib0h	905	52	as	as	IN
cord-021419-nypnib0h	905	53	opposed	oppose	VBN
cord-021419-nypnib0h	905	54	to	to	IN
cord-021419-nypnib0h	905	55	related	relate	VBN
cord-021419-nypnib0h	905	56	doxorubicin	doxorubicin	JJ
cord-021419-nypnib0h	905	57	derivatives	derivative	NNS
cord-021419-nypnib0h	905	58	,	,	,
cord-021419-nypnib0h	905	59	inhibit	inhibit	VB
cord-021419-nypnib0h	905	60	the	the	DT
cord-021419-nypnib0h	905	61	proliferation	proliferation	NN
cord-021419-nypnib0h	905	62	of	of	IN
cord-021419-nypnib0h	905	63	both	both	DT
cord-021419-nypnib0h	905	64	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	905	65	-	-	HYPH
cord-021419-nypnib0h	905	66	sensitive	sensitive	JJ
cord-021419-nypnib0h	905	67	and	and	CC
cord-021419-nypnib0h	905	68	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	905	69	-	-	HYPH
cord-021419-nypnib0h	905	70	resistant	resistant	JJ
cord-021419-nypnib0h	905	71	tumour	tumour	NN
cord-021419-nypnib0h	905	72	cell	cell	NN
cord-021419-nypnib0h	905	73	lines	line	NNS
cord-021419-nypnib0h	905	74	.	.	.
cord-021419-nypnib0h	906	1	96	96	CD
cord-021419-nypnib0h	907	1	A	a	DT
cord-021419-nypnib0h	907	2	new	new	JJ
cord-021419-nypnib0h	907	3	water	water	NN
cord-021419-nypnib0h	907	4	-	-	HYPH
cord-021419-nypnib0h	907	5	soluble	soluble	JJ
cord-021419-nypnib0h	907	6	depot	depot	NN
cord-021419-nypnib0h	907	7	form	form	NN
cord-021419-nypnib0h	907	8	of	of	IN
cord-021419-nypnib0h	907	9	doxorubicin	doxorubicin	NN
cord-021419-nypnib0h	907	10	with	with	IN
cord-021419-nypnib0h	907	11	the	the	DT
cord-021419-nypnib0h	907	12	high	high	JJ
cord-021419-nypnib0h	907	13	-	-	HYPH
cord-021419-nypnib0h	907	14	molecular	molecular	JJ
cord-021419-nypnib0h	907	15	-	-	HYPH
cord-021419-nypnib0h	907	16	mass	mass	NN
cord-021419-nypnib0h	907	17	polysaccharide	polysaccharide	NN
cord-021419-nypnib0h	907	18	galactomannan	galactomannan	NNP
cord-021419-nypnib0h	907	19	DAVANAT	DAVANAT	NNP
cord-021419-nypnib0h	907	20	was	be	VBD
cord-021419-nypnib0h	907	21	constructed	construct	VBN
cord-021419-nypnib0h	908	1	and	and	CC
cord-021419-nypnib0h	908	2	it	-PRON-	PRP
cord-021419-nypnib0h	908	3	was	be	VBD
cord-021419-nypnib0h	908	4	shown	show	VBN
cord-021419-nypnib0h	908	5	that	that	IN
cord-021419-nypnib0h	908	6	it	-PRON-	PRP
cord-021419-nypnib0h	908	7	exhibits	exhibit	VBZ
cord-021419-nypnib0h	908	8	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	908	9	activity	activity	NN
cord-021419-nypnib0h	908	10	against	against	IN
cord-021419-nypnib0h	908	11	three	three	CD
cord-021419-nypnib0h	908	12	tumour	tumour	NN
cord-021419-nypnib0h	908	13	cell	cell	NN
cord-021419-nypnib0h	908	14	lines	line	NNS
cord-021419-nypnib0h	908	15	.	.	.
cord-021419-nypnib0h	909	1	94	94	CD
cord-021419-nypnib0h	909	2	,	,	,
cord-021419-nypnib0h	909	3	95	95	CD
cord-021419-nypnib0h	909	4	Series	Series	NNP
cord-021419-nypnib0h	909	5	of	of	IN
cord-021419-nypnib0h	909	6	new	new	JJ
cord-021419-nypnib0h	909	7	heliomycin	heliomycin	NNP
cord-021419-nypnib0h	909	8	analogues	analogue	NNS
cord-021419-nypnib0h	909	9	Ð	Ð	NNP
cord-021419-nypnib0h	909	10	water	water	NN
cord-021419-nypnib0h	909	11	-	-	HYPH
cord-021419-nypnib0h	909	12	soluble	soluble	JJ
cord-021419-nypnib0h	909	13	salts	salt	NNS
cord-021419-nypnib0h	909	14	of	of	IN
cord-021419-nypnib0h	909	15	amino	amino	NN
cord-021419-nypnib0h	909	16	derivatives	derivative	NNS
cord-021419-nypnib0h	909	17	Ð	Ð	NNS
cord-021419-nypnib0h	909	18	were	be	VBD
cord-021419-nypnib0h	909	19	synthesized	synthesize	VBN
cord-021419-nypnib0h	909	20	and	and	CC
cord-021419-nypnib0h	909	21	these	these	DT
cord-021419-nypnib0h	909	22	compounds	compound	NNS
cord-021419-nypnib0h	909	23	were	be	VBD
cord-021419-nypnib0h	909	24	shown	show	VBN
cord-021419-nypnib0h	909	25	to	to	TO
cord-021419-nypnib0h	909	26	have	have	VB
cord-021419-nypnib0h	909	27	high	high	JJ
cord-021419-nypnib0h	909	28	antiproliferative	antiproliferative	JJ
cord-021419-nypnib0h	909	29	activity	activity	NN
cord-021419-nypnib0h	909	30	against	against	IN
cord-021419-nypnib0h	909	31	many	many	JJ
cord-021419-nypnib0h	909	32	tumour	tumour	NN
cord-021419-nypnib0h	909	33	cell	cell	NN
cord-021419-nypnib0h	909	34	lines	line	NNS
cord-021419-nypnib0h	909	35	and	and	CC
cord-021419-nypnib0h	909	36	inhibitory	inhibitory	JJ
cord-021419-nypnib0h	909	37	activity	activity	NN
cord-021419-nypnib0h	909	38	against	against	IN
cord-021419-nypnib0h	909	39	different	different	JJ
cord-021419-nypnib0h	909	40	targets	target	NNS
cord-021419-nypnib0h	909	41	.	.	.
cord-021419-nypnib0h	910	1	100	100	CD
cord-021419-nypnib0h	911	1	The	the	DT
cord-021419-nypnib0h	911	2	value	value	NN
cord-021419-nypnib0h	911	3	of	of	IN
cord-021419-nypnib0h	911	4	these	these	DT
cord-021419-nypnib0h	911	5	studies	study	NNS
cord-021419-nypnib0h	911	6	is	be	VBZ
cord-021419-nypnib0h	911	7	that	that	IN
cord-021419-nypnib0h	911	8	the	the	DT
cord-021419-nypnib0h	911	9	majority	majority	NN
cord-021419-nypnib0h	911	10	of	of	IN
cord-021419-nypnib0h	911	11	aminomethyl	aminomethyl	NNP
cord-021419-nypnib0h	911	12	derivatives	derivative	NNS
cord-021419-nypnib0h	911	13	of	of	IN
cord-021419-nypnib0h	911	14	heliomycin	heliomycin	NNS
cord-021419-nypnib0h	911	15	are	be	VBP
cord-021419-nypnib0h	911	16	active	active	JJ
cord-021419-nypnib0h	911	17	against	against	IN
cord-021419-nypnib0h	911	18	both	both	DT
cord-021419-nypnib0h	911	19	wild	wild	JJ
cord-021419-nypnib0h	911	20	-	-	HYPH
cord-021419-nypnib0h	911	21	type	type	NN
cord-021419-nypnib0h	911	22	and	and	CC
cord-021419-nypnib0h	911	23	drugresistant	drugresistant	JJ
cord-021419-nypnib0h	911	24	cancer	cancer	NN
cord-021419-nypnib0h	911	25	cells	cell	NNS
cord-021419-nypnib0h	911	26	at	at	IN
cord-021419-nypnib0h	911	27	micromolar	micromolar	NNP
cord-021419-nypnib0h	911	28	or	or	CC
cord-021419-nypnib0h	911	29	submicromolar	submicromolar	NNP
cord-021419-nypnib0h	911	30	concentrations	concentration	NNS
cord-021419-nypnib0h	911	31	.	.	.
cord-021419-nypnib0h	912	1	The	the	DT
cord-021419-nypnib0h	912	2	method	method	NN
cord-021419-nypnib0h	912	3	is	be	VBZ
cord-021419-nypnib0h	912	4	protected	protect	VBN
cord-021419-nypnib0h	912	5	by	by	IN
cord-021419-nypnib0h	912	6	a	a	DT
cord-021419-nypnib0h	912	7	patent	patent	NN
cord-021419-nypnib0h	912	8	.	.	.
cord-021419-nypnib0h	913	1	101	101	CD
cord-021419-nypnib0h	914	1	Targeted	target	VBN
cord-021419-nypnib0h	914	2	chemical	chemical	NN
cord-021419-nypnib0h	914	3	modifications	modification	NNS
cord-021419-nypnib0h	914	4	of	of	IN
cord-021419-nypnib0h	914	5	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	914	6	are	be	VBP
cord-021419-nypnib0h	914	7	not	not	RB
cord-021419-nypnib0h	914	8	only	only	RB
cord-021419-nypnib0h	914	9	performed	perform	VBN
cord-021419-nypnib0h	914	10	in	in	IN
cord-021419-nypnib0h	914	11	order	order	NN
cord-021419-nypnib0h	914	12	to	to	TO
cord-021419-nypnib0h	914	13	prepare	prepare	VB
cord-021419-nypnib0h	914	14	new	new	JJ
cord-021419-nypnib0h	914	15	potential	potential	JJ
cord-021419-nypnib0h	914	16	drugs	drug	NNS
cord-021419-nypnib0h	914	17	of	of	IN
cord-021419-nypnib0h	914	18	a	a	DT
cord-021419-nypnib0h	914	19	new	new	JJ
cord-021419-nypnib0h	914	20	generation	generation	NN
cord-021419-nypnib0h	914	21	but	but	CC
cord-021419-nypnib0h	914	22	are	be	VBP
cord-021419-nypnib0h	914	23	used	use	VBN
cord-021419-nypnib0h	914	24	as	as	IN
cord-021419-nypnib0h	914	25	an	an	DT
cord-021419-nypnib0h	914	26	efficient	efficient	JJ
cord-021419-nypnib0h	914	27	tool	tool	NN
cord-021419-nypnib0h	914	28	for	for	IN
cord-021419-nypnib0h	914	29	investigation	investigation	NN
cord-021419-nypnib0h	914	30	of	of	IN
cord-021419-nypnib0h	914	31	the	the	DT
cord-021419-nypnib0h	914	32	mechanisms	mechanism	NNS
cord-021419-nypnib0h	914	33	of	of	IN
cord-021419-nypnib0h	914	34	action	action	NN
cord-021419-nypnib0h	914	35	on	on	IN
cord-021419-nypnib0h	914	36	bacterial	bacterial	JJ
cord-021419-nypnib0h	914	37	or	or	CC
cord-021419-nypnib0h	914	38	tumour	tumour	NN
cord-021419-nypnib0h	914	39	cells	cell	NNS
cord-021419-nypnib0h	914	40	.	.	.
cord-021419-nypnib0h	915	1	It	-PRON-	PRP
cord-021419-nypnib0h	915	2	should	should	MD
cord-021419-nypnib0h	915	3	be	be	VB
cord-021419-nypnib0h	915	4	emphasized	emphasize	VBN
cord-021419-nypnib0h	915	5	that	that	IN
cord-021419-nypnib0h	915	6	many	many	JJ
cord-021419-nypnib0h	915	7	potent	potent	JJ
cord-021419-nypnib0h	915	8	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	915	9	are	be	VBP
cord-021419-nypnib0h	915	10	indispensable	indispensable	JJ
cord-021419-nypnib0h	915	11	tools	tool	NNS
cord-021419-nypnib0h	915	12	for	for	IN
cord-021419-nypnib0h	915	13	molecular	molecular	JJ
cord-021419-nypnib0h	915	14	biology	biology	NN
cord-021419-nypnib0h	915	15	research	research	NN
cord-021419-nypnib0h	915	16	of	of	IN
cord-021419-nypnib0h	915	17	the	the	DT
cord-021419-nypnib0h	915	18	living	live	VBG
cord-021419-nypnib0h	915	19	world	world	NN
cord-021419-nypnib0h	915	20	.	.	.
cord-021419-nypnib0h	916	1	Such	such	JJ
cord-021419-nypnib0h	916	2	comprehensive	comprehensive	JJ
cord-021419-nypnib0h	916	3	studies	study	NNS
cord-021419-nypnib0h	916	4	can	can	MD
cord-021419-nypnib0h	916	5	lead	lead	VB
cord-021419-nypnib0h	916	6	to	to	IN
cord-021419-nypnib0h	916	7	the	the	DT
cord-021419-nypnib0h	916	8	design	design	NN
cord-021419-nypnib0h	916	9	and	and	CC
cord-021419-nypnib0h	916	10	synthesis	synthesis	NN
cord-021419-nypnib0h	916	11	of	of	IN
cord-021419-nypnib0h	916	12	new	new	JJ
cord-021419-nypnib0h	916	13	-	-	HYPH
cord-021419-nypnib0h	916	14	generation	generation	NN
cord-021419-nypnib0h	916	15	drugs	drug	NNS
cord-021419-nypnib0h	916	16	,	,	,
cord-021419-nypnib0h	916	17	which	which	WDT
cord-021419-nypnib0h	916	18	would	would	MD
cord-021419-nypnib0h	916	19	be	be	VB
cord-021419-nypnib0h	916	20	more	more	RBR
cord-021419-nypnib0h	916	21	effective	effective	JJ
cord-021419-nypnib0h	916	22	than	than	IN
cord-021419-nypnib0h	916	23	the	the	DT
cord-021419-nypnib0h	916	24	starting	start	VBG
cord-021419-nypnib0h	916	25	antibiotics	antibiotic	NNS
cord-021419-nypnib0h	916	26	and	and	CC
cord-021419-nypnib0h	916	27	which	which	WDT
cord-021419-nypnib0h	916	28	are	be	VBP
cord-021419-nypnib0h	916	29	of	of	IN
cord-021419-nypnib0h	916	30	theoretical	theoretical	JJ
cord-021419-nypnib0h	916	31	interest	interest	NN
cord-021419-nypnib0h	916	32	as	as	IN
cord-021419-nypnib0h	916	33	new	new	JJ
cord-021419-nypnib0h	916	34	compounds	compound	NNS
cord-021419-nypnib0h	916	35	with	with	IN
cord-021419-nypnib0h	916	36	high	high	JJ
cord-021419-nypnib0h	916	37	biological	biological	JJ
cord-021419-nypnib0h	916	38	activity	activity	NN
cord-021419-nypnib0h	916	39	.	.	.
cord-021419-nypnib0h	917	1	Figures	figure	NNS
cord-021419-nypnib0h	917	2	2	2	CD
cord-021419-nypnib0h	917	3	,	,	,
cord-021419-nypnib0h	917	4	3	3	CD
cord-021419-nypnib0h	917	5	,	,	,
cord-021419-nypnib0h	917	6	5	5	CD
cord-021419-nypnib0h	917	7	and	and	CC
cord-021419-nypnib0h	917	8	6	6	CD
cord-021419-nypnib0h	917	9	were	be	VBD
cord-021419-nypnib0h	917	10	composed	compose	VBN
cord-021419-nypnib0h	917	11	by	by	IN
cord-021419-nypnib0h	917	12	the	the	DT
cord-021419-nypnib0h	917	13	authors	author	NNS
cord-021419-nypnib0h	917	14	based	base	VBN
cord-021419-nypnib0h	917	15	on	on	IN
cord-021419-nypnib0h	917	16	the	the	DT
cord-021419-nypnib0h	917	17	cited	cite	VBN
cord-021419-nypnib0h	917	18	publications	publication	NNS
cord-021419-nypnib0h	917	19	(	(	-LRB-
cord-021419-nypnib0h	917	20	the	the	DT
cord-021419-nypnib0h	917	21	references	reference	NNS
cord-021419-nypnib0h	917	22	are	be	VBP
cord-021419-nypnib0h	917	23	given	give	VBN
cord-021419-nypnib0h	917	24	in	in	IN
cord-021419-nypnib0h	917	25	the	the	DT
cord-021419-nypnib0h	917	26	figure	figure	NN
cord-021419-nypnib0h	917	27	captions	caption	NNS
cord-021419-nypnib0h	917	28	)	)	-RRB-
cord-021419-nypnib0h	917	29	.	.	.
cord-021419-nypnib0h	918	1	New	New	NNP
cord-021419-nypnib0h	918	2	Approaches	approach	NNS
cord-021419-nypnib0h	918	3	to	to	IN
cord-021419-nypnib0h	918	4	Natural	natural	JJ
cord-021419-nypnib0h	918	5	Anticancer	Anticancer	NNP
cord-021419-nypnib0h	918	6	Drugs	drug	NNS
cord-021419-nypnib0h	918	7	.	.	.
cord-021419-nypnib0h	919	1	Springer	Springer	NNP
cord-021419-nypnib0h	919	2	Briefs	Briefs	NNP
cord-021419-nypnib0h	919	3	in	in	IN
cord-021419-nypnib0h	919	4	Pharmaceutical	Pharmaceutical	NNP
cord-021419-nypnib0h	919	5	Science	Science	NNP
cord-021419-nypnib0h	919	6	and	and	CC
cord-021419-nypnib0h	919	7	Drug	Drug	NNP
cord-021419-nypnib0h	919	8	Development	Development	NNP
cord-021419-nypnib0h	919	9	Antibiotics	Antibiotics	NNPS
cord-021419-nypnib0h	919	10	:	:	:
cord-021419-nypnib0h	919	11	Challenges	challenge	NNS
cord-021419-nypnib0h	919	12	,	,	,
cord-021419-nypnib0h	919	13	Mechanisms	Mechanisms	NNPS
cord-021419-nypnib0h	919	14	,	,	,
cord-021419-nypnib0h	919	15	Opportunities	Opportunities	NNPS
cord-021419-nypnib0h	919	16	Markovnikov	Markovnikov	NNP
cord-021419-nypnib0h	919	17	Congress	Congress	NNP
cord-021419-nypnib0h	919	18	on	on	IN
cord-021419-nypnib0h	919	19	Organic	Organic	NNP
cord-021419-nypnib0h	919	20	Chemistry	Chemistry	NNP
cord-021419-nypnib0h	920	1	(	(	-LRB-
cord-021419-nypnib0h	920	2	Book	Book	NNP
cord-021419-nypnib0h	920	3	of	of	IN
cord-021419-nypnib0h	920	4	Abstracts	Abstracts	NNPS
cord-021419-nypnib0h	920	5	)	)	-RRB-
cord-021419-nypnib0h	921	1	Handbook	Handbook	NNP
cord-021419-nypnib0h	921	2	of	of	IN
cord-021419-nypnib0h	921	3	Experimental	Experimental	NNP
cord-021419-nypnib0h	921	4	Pharmacology	Pharmacology	NNP
cord-021419-nypnib0h	921	5	Doctoral	Doctoral	NNP
cord-021419-nypnib0h	921	6	Thesis	Thesis	NNP
cord-021419-nypnib0h	921	7	in	in	IN
cord-021419-nypnib0h	921	8	Chemical	Chemical	NNP
cord-021419-nypnib0h	921	9	Sciences	Sciences	NNPS
cord-021419-nypnib0h	921	10	,	,	,
cord-021419-nypnib0h	921	11	M.V.Lomonosov	M.V.Lomonosov	NNP
cord-021419-nypnib0h	921	12	Institute	Institute	NNP
cord-021419-nypnib0h	921	13	of	of	IN
cord-021419-nypnib0h	921	14	Fine	Fine	NNP
cord-021419-nypnib0h	921	15	Chemical	Chemical	NNP
cord-021419-nypnib0h	921	16	Technology	Technology	NNP
cord-021419-nypnib0h	921	17	Glycobiology	Glycobiology	NNP
cord-021419-nypnib0h	921	18	and	and	CC
cord-021419-nypnib0h	921	19	Drug	Drug	NNP
cord-021419-nypnib0h	921	20	Design	Design	NNP
cord-021419-nypnib0h	921	21	.	.	.
cord-021419-nypnib0h	922	1	(	(	-LRB-
cord-021419-nypnib0h	922	2	ACS	ACS	NNP
cord-021419-nypnib0h	922	3	Symp	Symp	NNP
cord-021419-nypnib0h	922	4	.	.	.
cord-021419-nypnib0h	923	1	Ser	Ser	NNP
cord-021419-nypnib0h	923	2	.	.	NNP
cord-021419-nypnib0h	923	3	1102	1102	CD
cord-021419-nypnib0h	924	1	)	)	-RRB-
cord-021419-nypnib0h	924	2	Carbohydrates	carbohydrate	NNS
cord-021419-nypnib0h	924	3	and	and	CC
cord-021419-nypnib0h	924	4	Drug	Drug	NNP
cord-021419-nypnib0h	924	5	Design	Design	NNP
cord-021419-nypnib0h	924	6	.	.	.
cord-021419-nypnib0h	925	1	(	(	-LRB-
cord-021419-nypnib0h	925	2	ASC	ASC	NNP
cord-021419-nypnib0h	925	3	Symp	Symp	NNP
cord-021419-nypnib0h	925	4	.	.	.
cord-021419-nypnib0h	926	1	Ser	Ser	NNP
cord-021419-nypnib0h	926	2	.	.	NNP
cord-021419-nypnib0h	926	3	932	932	CD
cord-021419-nypnib0h	926	4	)	)	-RRB-