id	sid	tid	token	lemma	pos
cord-016187-58rqc0cg	1	1	key	key	JJ
cord-016187-58rqc0cg	1	2	:	:	:
cord-016187-58rqc0cg	1	3	cord-016187	cord-016187	NNP
cord-016187-58rqc0cg	1	4	-	-	HYPH
cord-016187-58rqc0cg	1	5	58rqc0cg	58rqc0cg	VBN
cord-016187-58rqc0cg	1	6	authors	author	NNS
cord-016187-58rqc0cg	1	7	:	:	:
cord-016187-58rqc0cg	1	8	Opal	Opal	NNP
cord-016187-58rqc0cg	1	9	,	,	,
cord-016187-58rqc0cg	1	10	S.	S.	NNP
cord-016187-58rqc0cg	1	11	M.	M.	NNP
cord-016187-58rqc0cg	2	1	title	title	NN
cord-016187-58rqc0cg	2	2	:	:	:
cord-016187-58rqc0cg	3	1	The	the	DT
cord-016187-58rqc0cg	3	2	Challenge	Challenge	NNP
cord-016187-58rqc0cg	3	3	of	of	IN
cord-016187-58rqc0cg	3	4	Emerging	Emerging	NNP
cord-016187-58rqc0cg	3	5	Infections	Infections	NNPS
cord-016187-58rqc0cg	3	6	and	and	CC
cord-016187-58rqc0cg	3	7	Progressive	Progressive	NNP
cord-016187-58rqc0cg	3	8	Antibiotic	Antibiotic	NNP
cord-016187-58rqc0cg	3	9	Resistance	Resistance	NNP
cord-016187-58rqc0cg	3	10	date	date	NN
cord-016187-58rqc0cg	3	11	:	:	:
cord-016187-58rqc0cg	3	12	2006	2006	CD
cord-016187-58rqc0cg	3	13	journal	journal	NN
cord-016187-58rqc0cg	3	14	:	:	:
cord-016187-58rqc0cg	3	15	Intensive	Intensive	NNP
cord-016187-58rqc0cg	3	16	Care	Care	NNP
cord-016187-58rqc0cg	3	17	Medicine	medicine	NN
cord-016187-58rqc0cg	3	18	in	in	IN
cord-016187-58rqc0cg	3	19	10	10	CD
cord-016187-58rqc0cg	3	20	Years	year	NNS
cord-016187-58rqc0cg	4	1	DOI	DOI	NNP
cord-016187-58rqc0cg	4	2	:	:	:
cord-016187-58rqc0cg	5	1	10.1007/3	10.1007/3	CD
cord-016187-58rqc0cg	5	2	-	-	HYPH
cord-016187-58rqc0cg	5	3	540	540	CD
cord-016187-58rqc0cg	5	4	-	-	HYPH
cord-016187-58rqc0cg	5	5	29730	29730	CD
cord-016187-58rqc0cg	5	6	-	-	HYPH
cord-016187-58rqc0cg	5	7	8_6	8_6	CD
cord-016187-58rqc0cg	6	1	sha	sha	NNP
cord-016187-58rqc0cg	6	2	:	:	:
cord-016187-58rqc0cg	6	3	938a619478f04fc715d5ac0c179ffedbec2e2511	938a619478f04fc715d5ac0c179ffedbec2e2511	CD
cord-016187-58rqc0cg	6	4	doc_id	doc_id	CD
cord-016187-58rqc0cg	6	5	:	:	:
cord-016187-58rqc0cg	7	1	16187	16187	CD
cord-016187-58rqc0cg	7	2	cord_uid	cord_uid	NN
cord-016187-58rqc0cg	7	3	:	:	:
cord-016187-58rqc0cg	8	1	58rqc0cg	58rqc0cg	LS
cord-016187-58rqc0cg	8	2	nan	nan	NNP
cord-016187-58rqc0cg	8	3	Our	-PRON-	PRP$
cord-016187-58rqc0cg	8	4	collective	collective	JJ
cord-016187-58rqc0cg	8	5	vulnerability	vulnerability	NN
cord-016187-58rqc0cg	8	6	to	to	IN
cord-016187-58rqc0cg	8	7	the	the	DT
cord-016187-58rqc0cg	8	8	threat	threat	NN
cord-016187-58rqc0cg	8	9	of	of	IN
cord-016187-58rqc0cg	8	10	emerging	emerge	VBG
cord-016187-58rqc0cg	8	11	microbial	microbial	JJ
cord-016187-58rqc0cg	8	12	pathogens	pathogen	NNS
cord-016187-58rqc0cg	8	13	remains	remain	VBZ
cord-016187-58rqc0cg	8	14	disturbingly	disturbingly	RB
cord-016187-58rqc0cg	8	15	evident	evident	JJ
cord-016187-58rqc0cg	8	16	as	as	IN
cord-016187-58rqc0cg	8	17	we	-PRON-	PRP
cord-016187-58rqc0cg	8	18	enter	enter	VBP
cord-016187-58rqc0cg	8	19	the	the	DT
cord-016187-58rqc0cg	8	20	twenty	twenty	CD
cord-016187-58rqc0cg	8	21	-	-	HYPH
cord-016187-58rqc0cg	8	22	fi	fi	NN
cord-016187-58rqc0cg	8	23	rst	rst	NN
cord-016187-58rqc0cg	8	24	century	century	NN
cord-016187-58rqc0cg	8	25	.	.	.
cord-016187-58rqc0cg	9	1	Despite	despite	IN
cord-016187-58rqc0cg	9	2	two	two	CD
cord-016187-58rqc0cg	9	3	centuries	century	NNS
cord-016187-58rqc0cg	9	4	of	of	IN
cord-016187-58rqc0cg	9	5	knowledge	knowledge	NN
cord-016187-58rqc0cg	9	6	about	about	IN
cord-016187-58rqc0cg	9	7	the	the	DT
cord-016187-58rqc0cg	9	8	germ	germ	NN
cord-016187-58rqc0cg	9	9	theory	theory	NN
cord-016187-58rqc0cg	9	10	of	of	IN
cord-016187-58rqc0cg	9	11	disease	disease	NN
cord-016187-58rqc0cg	9	12	,	,	,
cord-016187-58rqc0cg	9	13	breaking	break	VBG
cord-016187-58rqc0cg	9	14	the	the	DT
cord-016187-58rqc0cg	9	15	genetic	genetic	JJ
cord-016187-58rqc0cg	9	16	code	code	NN
cord-016187-58rqc0cg	9	17	,	,	,
cord-016187-58rqc0cg	9	18	and	and	CC
cord-016187-58rqc0cg	9	19	sequencing	sequence	VBG
cord-016187-58rqc0cg	9	20	the	the	DT
cord-016187-58rqc0cg	9	21	genomes	genome	NNS
cord-016187-58rqc0cg	9	22	of	of	IN
cord-016187-58rqc0cg	9	23	virtually	virtually	RB
cord-016187-58rqc0cg	9	24	every	every	DT
cord-016187-58rqc0cg	9	25	major	major	JJ
cord-016187-58rqc0cg	9	26	bacterial	bacterial	JJ
cord-016187-58rqc0cg	9	27	and	and	CC
cord-016187-58rqc0cg	9	28	viral	viral	JJ
cord-016187-58rqc0cg	9	29	pathogen	pathogen	NN
cord-016187-58rqc0cg	9	30	capable	capable	JJ
cord-016187-58rqc0cg	9	31	of	of	IN
cord-016187-58rqc0cg	9	32	causing	cause	VBG
cord-016187-58rqc0cg	9	33	disease	disease	NN
cord-016187-58rqc0cg	9	34	in	in	IN
cord-016187-58rqc0cg	9	35	humankind	humankind	NN
cord-016187-58rqc0cg	9	36	,	,	,
cord-016187-58rqc0cg	9	37	we	-PRON-	PRP
cord-016187-58rqc0cg	9	38	still	still	RB
cord-016187-58rqc0cg	9	39	fi	fi	VBP
cord-016187-58rqc0cg	9	40	nd	nd	NNP
cord-016187-58rqc0cg	9	41	ourselves	-PRON-	PRP
cord-016187-58rqc0cg	9	42	susceptible	susceptible	JJ
cord-016187-58rqc0cg	9	43	to	to	IN
cord-016187-58rqc0cg	9	44	infectious	infectious	JJ
cord-016187-58rqc0cg	9	45	diseases	disease	NNS
cord-016187-58rqc0cg	9	46	.	.	.
cord-016187-58rqc0cg	10	1	Densely	densely	RB
cord-016187-58rqc0cg	10	2	concentrated	concentrated	JJ
cord-016187-58rqc0cg	10	3	cities	city	NNS
cord-016187-58rqc0cg	10	4	with	with	IN
cord-016187-58rqc0cg	10	5	interconnected	interconnected	JJ
cord-016187-58rqc0cg	10	6	human	human	JJ
cord-016187-58rqc0cg	10	7	societies	society	NNS
cord-016187-58rqc0cg	10	8	linked	link	VBN
cord-016187-58rqc0cg	10	9	by	by	IN
cord-016187-58rqc0cg	10	10	international	international	JJ
cord-016187-58rqc0cg	10	11	aviation	aviation	NN
cord-016187-58rqc0cg	10	12	put	put	VBD
cord-016187-58rqc0cg	10	13	us	-PRON-	PRP
cord-016187-58rqc0cg	10	14	at	at	IN
cord-016187-58rqc0cg	10	15	continued	continued	JJ
cord-016187-58rqc0cg	10	16	risk	risk	NN
cord-016187-58rqc0cg	10	17	from	from	IN
cord-016187-58rqc0cg	10	18	future	future	JJ
cord-016187-58rqc0cg	10	19	epidemics	epidemic	NNS
cord-016187-58rqc0cg	10	20	that	that	WDT
cord-016187-58rqc0cg	10	21	will	will	MD
cord-016187-58rqc0cg	10	22	inevitably	inevitably	RB
cord-016187-58rqc0cg	10	23	occur	occur	VB
cord-016187-58rqc0cg	10	24	[	[	-LRB-
cord-016187-58rqc0cg	10	25	1	1	CD
cord-016187-58rqc0cg	10	26	]	]	-RRB-
cord-016187-58rqc0cg	10	27	.	.	.
cord-016187-58rqc0cg	11	1	The	the	DT
cord-016187-58rqc0cg	11	2	ever	ever	RB
cord-016187-58rqc0cg	11	3	expanding	expand	VBG
cord-016187-58rqc0cg	11	4	population	population	NN
cord-016187-58rqc0cg	11	5	growth	growth	NN
cord-016187-58rqc0cg	11	6	of	of	IN
cord-016187-58rqc0cg	11	7	our	-PRON-	PRP$
cord-016187-58rqc0cg	11	8	species	specie	NNS
cord-016187-58rqc0cg	11	9	will	will	MD
cord-016187-58rqc0cg	11	10	force	force	VB
cord-016187-58rqc0cg	11	11	environmental	environmental	JJ
cord-016187-58rqc0cg	11	12	change	change	NN
cord-016187-58rqc0cg	11	13	as	as	IN
cord-016187-58rqc0cg	11	14	we	-PRON-	PRP
cord-016187-58rqc0cg	11	15	venture	venture	VBP
cord-016187-58rqc0cg	11	16	into	into	IN
cord-016187-58rqc0cg	11	17	sparsely	sparsely	RB
cord-016187-58rqc0cg	11	18	inhabited	inhabit	VBN
cord-016187-58rqc0cg	11	19	rainforests	rainforest	NNS
cord-016187-58rqc0cg	11	20	,	,	,
cord-016187-58rqc0cg	11	21	populate	populate	VB
cord-016187-58rqc0cg	11	22	remote	remote	JJ
cord-016187-58rqc0cg	11	23	ecosystems	ecosystem	NNS
cord-016187-58rqc0cg	11	24	and	and	CC
cord-016187-58rqc0cg	11	25	cultivate	cultivate	VB
cord-016187-58rqc0cg	11	26	natural	natural	JJ
cord-016187-58rqc0cg	11	27	habitats	habitat	NNS
cord-016187-58rqc0cg	11	28	to	to	TO
cord-016187-58rqc0cg	11	29	support	support	VB
cord-016187-58rqc0cg	11	30	our	-PRON-	PRP$
cord-016187-58rqc0cg	11	31	voracious	voracious	JJ
cord-016187-58rqc0cg	11	32	human	human	JJ
cord-016187-58rqc0cg	11	33	appetite	appetite	NN
cord-016187-58rqc0cg	11	34	for	for	IN
cord-016187-58rqc0cg	11	35	goods	good	NNS
cord-016187-58rqc0cg	11	36	and	and	CC
cord-016187-58rqc0cg	11	37	services	service	NNS
cord-016187-58rqc0cg	11	38	.	.	.
cord-016187-58rqc0cg	12	1	Global	global	JJ
cord-016187-58rqc0cg	12	2	warming	warming	NN
cord-016187-58rqc0cg	12	3	,	,	,
cord-016187-58rqc0cg	12	4	environmental	environmental	JJ
cord-016187-58rqc0cg	12	5	degradation	degradation	NN
cord-016187-58rqc0cg	12	6	and	and	CC
cord-016187-58rqc0cg	12	7	land	land	NN
cord-016187-58rqc0cg	12	8	development	development	NN
cord-016187-58rqc0cg	12	9	along	along	IN
cord-016187-58rqc0cg	12	10	with	with	IN
cord-016187-58rqc0cg	12	11	human	human	JJ
cord-016187-58rqc0cg	12	12	upheavals	upheaval	NNS
cord-016187-58rqc0cg	12	13	and	and	CC
cord-016187-58rqc0cg	12	14	natural	natural	JJ
cord-016187-58rqc0cg	12	15	calamities	calamity	NNS
cord-016187-58rqc0cg	12	16	will	will	MD
cord-016187-58rqc0cg	12	17	create	create	VB
cord-016187-58rqc0cg	12	18	new	new	JJ
cord-016187-58rqc0cg	12	19	outbreaks	outbreak	NNS
cord-016187-58rqc0cg	12	20	with	with	IN
cord-016187-58rqc0cg	12	21	novel	novel	JJ
cord-016187-58rqc0cg	12	22	pathogens	pathogen	NNS
cord-016187-58rqc0cg	12	23	and	and	CC
cord-016187-58rqc0cg	12	24	renew	renew	VB
cord-016187-58rqc0cg	12	25	the	the	DT
cord-016187-58rqc0cg	12	26	spread	spread	NN
cord-016187-58rqc0cg	12	27	of	of	IN
cord-016187-58rqc0cg	12	28	ancient	ancient	JJ
cord-016187-58rqc0cg	12	29	scourges	scourge	NNS
cord-016187-58rqc0cg	12	30	like	like	IN
cord-016187-58rqc0cg	12	31	cholera	cholera	NN
cord-016187-58rqc0cg	12	32	[	[	-LRB-
cord-016187-58rqc0cg	12	33	2	2	CD
cord-016187-58rqc0cg	12	34	]	]	-RRB-
cord-016187-58rqc0cg	12	35	and	and	CC
cord-016187-58rqc0cg	12	36	plague	plague	NN
cord-016187-58rqc0cg	12	37	[	[	-LRB-
cord-016187-58rqc0cg	12	38	3	3	CD
cord-016187-58rqc0cg	12	39	]	]	-RRB-
cord-016187-58rqc0cg	12	40	.	.	.
cord-016187-58rqc0cg	13	1	Numerous	numerous	JJ
cord-016187-58rqc0cg	13	2	examples	example	NNS
cord-016187-58rqc0cg	13	3	of	of	IN
cord-016187-58rqc0cg	13	4	intercontinental	intercontinental	JJ
cord-016187-58rqc0cg	13	5	spread	spread	NN
cord-016187-58rqc0cg	13	6	of	of	IN
cord-016187-58rqc0cg	13	7	microbial	microbial	JJ
cord-016187-58rqc0cg	13	8	pathogens	pathogen	NNS
cord-016187-58rqc0cg	13	9	within	within	IN
cord-016187-58rqc0cg	13	10	the	the	DT
cord-016187-58rqc0cg	13	11	last	last	JJ
cord-016187-58rqc0cg	13	12	fi	fi	NN
cord-016187-58rqc0cg	13	13	ve	ve	VBD
cord-016187-58rqc0cg	13	14	years	year	NNS
cord-016187-58rqc0cg	13	15	alone	alone	RB
cord-016187-58rqc0cg	13	16	give	give	VB
cord-016187-58rqc0cg	13	17	notice	notice	NN
cord-016187-58rqc0cg	13	18	of	of	IN
cord-016187-58rqc0cg	13	19	the	the	DT
cord-016187-58rqc0cg	13	20	susceptibility	susceptibility	NN
cord-016187-58rqc0cg	13	21	of	of	IN
cord-016187-58rqc0cg	13	22	human	human	JJ
cord-016187-58rqc0cg	13	23	populations	population	NNS
cord-016187-58rqc0cg	13	24	to	to	IN
cord-016187-58rqc0cg	13	25	emerging	emerge	VBG
cord-016187-58rqc0cg	13	26	infectious	infectious	JJ
cord-016187-58rqc0cg	13	27	diseases	disease	NNS
cord-016187-58rqc0cg	13	28	(	(	-LRB-
cord-016187-58rqc0cg	13	29	Table	table	NN
cord-016187-58rqc0cg	13	30	1	1	CD
cord-016187-58rqc0cg	13	31	)	)	-RRB-
cord-016187-58rqc0cg	13	32	[	[	-LRB-
cord-016187-58rqc0cg	13	33	4	4	LS
cord-016187-58rqc0cg	13	34	]	]	-RRB-
cord-016187-58rqc0cg	13	35	[	[	-LRB-
cord-016187-58rqc0cg	13	36	5	5	CD
cord-016187-58rqc0cg	13	37	]	]	-RRB-
cord-016187-58rqc0cg	13	38	[	[	-LRB-
cord-016187-58rqc0cg	13	39	6	6	CD
cord-016187-58rqc0cg	13	40	]	]	-RRB-
cord-016187-58rqc0cg	13	41	[	[	-LRB-
cord-016187-58rqc0cg	13	42	7	7	CD
cord-016187-58rqc0cg	13	43	]	]	-RRB-
cord-016187-58rqc0cg	13	44	[	[	-LRB-
cord-016187-58rqc0cg	13	45	8	8	CD
cord-016187-58rqc0cg	13	46	]	]	-RRB-
cord-016187-58rqc0cg	13	47	[	[	-LRB-
cord-016187-58rqc0cg	13	48	9	9	CD
cord-016187-58rqc0cg	13	49	]	]	-RRB-
cord-016187-58rqc0cg	13	50	[	[	-LRB-
cord-016187-58rqc0cg	13	51	10	10	CD
cord-016187-58rqc0cg	13	52	]	]	-RRB-
cord-016187-58rqc0cg	13	53	[	[	-LRB-
cord-016187-58rqc0cg	13	54	11	11	CD
cord-016187-58rqc0cg	13	55	]	]	-RRB-
cord-016187-58rqc0cg	13	56	[	[	-LRB-
cord-016187-58rqc0cg	13	57	12	12	CD
cord-016187-58rqc0cg	13	58	]	]	-RRB-
cord-016187-58rqc0cg	13	59	[	[	-LRB-
cord-016187-58rqc0cg	13	60	13	13	CD
cord-016187-58rqc0cg	13	61	]	]	-RRB-
cord-016187-58rqc0cg	13	62	[	[	-LRB-
cord-016187-58rqc0cg	13	63	14	14	CD
cord-016187-58rqc0cg	13	64	]	]	-RRB-
cord-016187-58rqc0cg	13	65	[	[	-LRB-
cord-016187-58rqc0cg	13	66	15	15	CD
cord-016187-58rqc0cg	13	67	]	]	-RRB-
cord-016187-58rqc0cg	13	68	[	[	-LRB-
cord-016187-58rqc0cg	13	69	16	16	CD
cord-016187-58rqc0cg	13	70	]	]	-RRB-
cord-016187-58rqc0cg	13	71	[	[	-LRB-
cord-016187-58rqc0cg	13	72	17	17	CD
cord-016187-58rqc0cg	13	73	]	]	-RRB-
cord-016187-58rqc0cg	13	74	[	[	-LRB-
cord-016187-58rqc0cg	13	75	18	18	CD
cord-016187-58rqc0cg	13	76	]	]	-RRB-
cord-016187-58rqc0cg	13	77	[	[	-LRB-
cord-016187-58rqc0cg	13	78	19	19	CD
cord-016187-58rqc0cg	13	79	]	]	-RRB-
cord-016187-58rqc0cg	13	80	[	[	-LRB-
cord-016187-58rqc0cg	13	81	20	20	CD
cord-016187-58rqc0cg	13	82	]	]	-RRB-
cord-016187-58rqc0cg	13	83	.	.	.
cord-016187-58rqc0cg	14	1	This	this	DT
cord-016187-58rqc0cg	14	2	is	be	VBZ
cord-016187-58rqc0cg	14	3	perhaps	perhaps	RB
cord-016187-58rqc0cg	14	4	best	good	JJS
cord-016187-58rqc0cg	14	5	exemplifi	exemplifi	NN
cord-016187-58rqc0cg	14	6	ed	ed	NN
cord-016187-58rqc0cg	14	7	by	by	IN
cord-016187-58rqc0cg	14	8	the	the	DT
cord-016187-58rqc0cg	14	9	tragic	tragic	JJ
cord-016187-58rqc0cg	14	10	events	event	NNS
cord-016187-58rqc0cg	14	11	set	set	VBN
cord-016187-58rqc0cg	14	12	into	into	IN
cord-016187-58rqc0cg	14	13	motion	motion	NN
cord-016187-58rqc0cg	14	14	in	in	IN
cord-016187-58rqc0cg	14	15	late	late	JJ
cord-016187-58rqc0cg	14	16	2002	2002	CD
cord-016187-58rqc0cg	14	17	when	when	WRB
cord-016187-58rqc0cg	14	18	a	a	DT
cord-016187-58rqc0cg	14	19	previously	previously	RB
cord-016187-58rqc0cg	14	20	unidentifi	unidentifi	JJ
cord-016187-58rqc0cg	14	21	ed	ed	NN
cord-016187-58rqc0cg	14	22	,	,	,
cord-016187-58rqc0cg	14	23	obscure	obscure	JJ
cord-016187-58rqc0cg	14	24	,	,	,
cord-016187-58rqc0cg	14	25	animal	animal	NN
cord-016187-58rqc0cg	14	26	coronavirus	coronavirus	NN
cord-016187-58rqc0cg	14	27	(	(	-LRB-
cord-016187-58rqc0cg	14	28	now	now	RB
cord-016187-58rqc0cg	14	29	known	know	VBN
cord-016187-58rqc0cg	14	30	as	as	IN
cord-016187-58rqc0cg	14	31	severe	severe	JJ
cord-016187-58rqc0cg	14	32	acute	acute	JJ
cord-016187-58rqc0cg	14	33	respiratory	respiratory	JJ
cord-016187-58rqc0cg	14	34	syndrome	syndrome	NN
cord-016187-58rqc0cg	14	35	[	[	-LRB-
cord-016187-58rqc0cg	14	36	SARS]-CoV	sars]-cov	NN
cord-016187-58rqc0cg	14	37	)	)	-RRB-
cord-016187-58rqc0cg	14	38	was	be	VBD
cord-016187-58rqc0cg	14	39	fi	fi	NNP
cord-016187-58rqc0cg	14	40	rst	rst	NNP
cord-016187-58rqc0cg	14	41	introduced	introduce	VBD
cord-016187-58rqc0cg	14	42	into	into	IN
cord-016187-58rqc0cg	14	43	an	an	DT
cord-016187-58rqc0cg	14	44	unsuspecting	unsuspecting	JJ
cord-016187-58rqc0cg	14	45	human	human	JJ
cord-016187-58rqc0cg	14	46	population	population	NN
cord-016187-58rqc0cg	14	47	in	in	IN
cord-016187-58rqc0cg	14	48	Southern	Southern	NNP
cord-016187-58rqc0cg	14	49	China	China	NNP
cord-016187-58rqc0cg	14	50	[	[	-LRB-
cord-016187-58rqc0cg	14	51	9	9	CD
cord-016187-58rqc0cg	14	52	]	]	-RRB-
cord-016187-58rqc0cg	14	53	.	.	.
cord-016187-58rqc0cg	15	1	Current	current	JJ
cord-016187-58rqc0cg	15	2	molecular	molecular	JJ
cord-016187-58rqc0cg	15	3	evidence	evidence	NN
cord-016187-58rqc0cg	15	4	indicates	indicate	VBZ
cord-016187-58rqc0cg	15	5	that	that	IN
cord-016187-58rqc0cg	15	6	a	a	DT
cord-016187-58rqc0cg	15	7	food	food	NN
cord-016187-58rqc0cg	15	8	handler	handler	NN
cord-016187-58rqc0cg	15	9	in	in	IN
cord-016187-58rqc0cg	15	10	an	an	DT
cord-016187-58rqc0cg	15	11	exotic	exotic	JJ
cord-016187-58rqc0cg	15	12	food	food	NN
cord-016187-58rqc0cg	15	13	'	'	POS
cord-016187-58rqc0cg	15	14	wet	wet	JJ
cord-016187-58rqc0cg	15	15	market	market	NN
cord-016187-58rqc0cg	15	16	'	'	''
cord-016187-58rqc0cg	15	17	in	in	IN
cord-016187-58rqc0cg	15	18	Guangdong	Guangdong	NNP
cord-016187-58rqc0cg	15	19	Province	Province	NNP
cord-016187-58rqc0cg	15	20	probably	probably	RB
cord-016187-58rqc0cg	15	21	fi	fi	VBP
cord-016187-58rqc0cg	15	22	rst	rst	NNP
cord-016187-58rqc0cg	15	23	became	become	VBD
cord-016187-58rqc0cg	15	24	infected	infect	VBN
cord-016187-58rqc0cg	15	25	by	by	IN
cord-016187-58rqc0cg	15	26	an	an	DT
cord-016187-58rqc0cg	15	27	animal	animal	NN
cord-016187-58rqc0cg	15	28	coronavirus	coronavirus	NN
cord-016187-58rqc0cg	15	29	from	from	IN
cord-016187-58rqc0cg	15	30	a	a	DT
cord-016187-58rqc0cg	15	31	civet	civet	NN
cord-016187-58rqc0cg	15	32	cat	cat	NN
cord-016187-58rqc0cg	15	33	.	.	.
cord-016187-58rqc0cg	16	1	This	this	DT
cord-016187-58rqc0cg	16	2	newly	newly	RB
cord-016187-58rqc0cg	16	3	derived	derive	VBN
cord-016187-58rqc0cg	16	4	animal	animal	NN
cord-016187-58rqc0cg	16	5	virus	virus	NN
cord-016187-58rqc0cg	16	6	was	be	VBD
cord-016187-58rqc0cg	16	7	adapt	adapt	VBN
cord-016187-58rqc0cg	16	8	at	at	IN
cord-016187-58rqc0cg	16	9	infecting	infect	VBG
cord-016187-58rqc0cg	16	10	humans	human	NNS
cord-016187-58rqc0cg	16	11	and	and	CC
cord-016187-58rqc0cg	16	12	was	be	VBD
cord-016187-58rqc0cg	16	13	effi	effi	NNP
cord-016187-58rqc0cg	16	14	ciently	ciently	RB
cord-016187-58rqc0cg	16	15	spread	spread	VBD
cord-016187-58rqc0cg	16	16	person	person	NN
cord-016187-58rqc0cg	16	17	-	-	HYPH
cord-016187-58rqc0cg	16	18	to	to	IN
cord-016187-58rqc0cg	16	19	-	-	HYPH
cord-016187-58rqc0cg	16	20	person	person	NN
cord-016187-58rqc0cg	16	21	by	by	IN
cord-016187-58rqc0cg	16	22	infected	infect	VBN
cord-016187-58rqc0cg	16	23	aerosol	aerosol	NN
cord-016187-58rqc0cg	16	24	[	[	-LRB-
cord-016187-58rqc0cg	16	25	10	10	CD
cord-016187-58rqc0cg	16	26	]	]	-RRB-
cord-016187-58rqc0cg	16	27	.	.	.
cord-016187-58rqc0cg	17	1	An	an	DT
cord-016187-58rqc0cg	17	2	ill	ill	JJ
cord-016187-58rqc0cg	17	3	Chinese	chinese	JJ
cord-016187-58rqc0cg	17	4	physician	physician	NN
cord-016187-58rqc0cg	17	5	from	from	IN
cord-016187-58rqc0cg	17	6	the	the	DT
cord-016187-58rqc0cg	17	7	affected	affected	JJ
cord-016187-58rqc0cg	17	8	region	region	NN
cord-016187-58rqc0cg	17	9	traveled	travel	VBD
cord-016187-58rqc0cg	17	10	to	to	IN
cord-016187-58rqc0cg	17	11	Hong	Hong	NNP
cord-016187-58rqc0cg	17	12	Kong	Kong	NNP
cord-016187-58rqc0cg	17	13	to	to	TO
cord-016187-58rqc0cg	17	14	attend	attend	VB
cord-016187-58rqc0cg	17	15	a	a	DT
cord-016187-58rqc0cg	17	16	wedding	wedding	NN
cord-016187-58rqc0cg	17	17	.	.	.
cord-016187-58rqc0cg	18	1	While	while	IN
cord-016187-58rqc0cg	18	2	spending	spend	VBG
cord-016187-58rqc0cg	18	3	a	a	DT
cord-016187-58rqc0cg	18	4	single	single	JJ
cord-016187-58rqc0cg	18	5	night	night	NN
cord-016187-58rqc0cg	18	6	in	in	IN
cord-016187-58rqc0cg	18	7	Amoy	Amoy	NNP
cord-016187-58rqc0cg	18	8	Garden	Garden	NNP
cord-016187-58rqc0cg	18	9	Hotel	Hotel	NNP
cord-016187-58rqc0cg	18	10	in	in	IN
cord-016187-58rqc0cg	18	11	the	the	DT
cord-016187-58rqc0cg	18	12	city	city	NN
cord-016187-58rqc0cg	18	13	,	,	,
cord-016187-58rqc0cg	18	14	this	this	DT
cord-016187-58rqc0cg	18	15	infected	infected	JJ
cord-016187-58rqc0cg	18	16	individual	individual	NN
cord-016187-58rqc0cg	18	17	appeared	appear	VBD
cord-016187-58rqc0cg	18	18	to	to	TO
cord-016187-58rqc0cg	18	19	spread	spread	VB
cord-016187-58rqc0cg	18	20	the	the	DT
cord-016187-58rqc0cg	18	21	virus	virus	NN
cord-016187-58rqc0cg	18	22	to	to	IN
cord-016187-58rqc0cg	18	23	at	at	RB
cord-016187-58rqc0cg	18	24	least	least	RBS
cord-016187-58rqc0cg	18	25	12	12	CD
cord-016187-58rqc0cg	18	26	other	other	JJ
cord-016187-58rqc0cg	18	27	hotel	hotel	NN
cord-016187-58rqc0cg	18	28	guests	guest	NNS
cord-016187-58rqc0cg	18	29	.	.	.
cord-016187-58rqc0cg	19	1	Over	over	IN
cord-016187-58rqc0cg	19	2	the	the	DT
cord-016187-58rqc0cg	19	3	next	next	JJ
cord-016187-58rqc0cg	19	4	several	several	JJ
cord-016187-58rqc0cg	19	5	days	day	NNS
cord-016187-58rqc0cg	19	6	these	these	DT
cord-016187-58rqc0cg	19	7	people	people	NNS
cord-016187-58rqc0cg	19	8	returned	return	VBD
cord-016187-58rqc0cg	19	9	to	to	IN
cord-016187-58rqc0cg	19	10	their	-PRON-	PRP$
cord-016187-58rqc0cg	19	11	homes	home	NNS
cord-016187-58rqc0cg	19	12	in	in	IN
cord-016187-58rqc0cg	19	13	fi	fi	NNP
cord-016187-58rqc0cg	19	14	ve	ve	VBD
cord-016187-58rqc0cg	19	15	different	different	JJ
cord-016187-58rqc0cg	19	16	countries	country	NNS
cord-016187-58rqc0cg	19	17	incubating	incubate	VBG
cord-016187-58rqc0cg	19	18	the	the	DT
cord-016187-58rqc0cg	19	19	SARS	SARS	NNP
cord-016187-58rqc0cg	19	20	-	-	HYPH
cord-016187-58rqc0cg	19	21	CoV	cov	NN
cord-016187-58rqc0cg	19	22	pathogen	pathogen	NN
cord-016187-58rqc0cg	19	23	in	in	IN
cord-016187-58rqc0cg	19	24	their	-PRON-	PRP$
cord-016187-58rqc0cg	19	25	respiratory	respiratory	JJ
cord-016187-58rqc0cg	19	26	secretions	secretion	NNS
cord-016187-58rqc0cg	19	27	.	.	.
cord-016187-58rqc0cg	20	1	Over	over	IN
cord-016187-58rqc0cg	20	2	the	the	DT
cord-016187-58rqc0cg	20	3	next	next	JJ
cord-016187-58rqc0cg	20	4	3	3	CD
cord-016187-58rqc0cg	20	5	-	-	SYM
cord-016187-58rqc0cg	20	6	4	4	CD
cord-016187-58rqc0cg	20	7	months	month	NNS
cord-016187-58rqc0cg	20	8	,	,	,
cord-016187-58rqc0cg	20	9	this	this	DT
cord-016187-58rqc0cg	20	10	newly	newly	RB
cord-016187-58rqc0cg	20	11	acquired	acquire	VBN
cord-016187-58rqc0cg	20	12	coronavirus	coronavirus	NN
cord-016187-58rqc0cg	20	13	spread	spread	VBD
cord-016187-58rqc0cg	20	14	to	to	IN
cord-016187-58rqc0cg	20	15	over	over	IN
cord-016187-58rqc0cg	20	16	27	27	CD
cord-016187-58rqc0cg	20	17	countries	country	NNS
cord-016187-58rqc0cg	20	18	worldwide	worldwide	RB
cord-016187-58rqc0cg	20	19	and	and	CC
cord-016187-58rqc0cg	20	20	caused	cause	VBD
cord-016187-58rqc0cg	20	21	over	over	IN
cord-016187-58rqc0cg	20	22	8000	8000	CD
cord-016187-58rqc0cg	20	23	cases	case	NNS
cord-016187-58rqc0cg	20	24	of	of	IN
cord-016187-58rqc0cg	20	25	SARS	SARS	NNP
cord-016187-58rqc0cg	20	26	resulting	result	VBG
cord-016187-58rqc0cg	20	27	in	in	IN
cord-016187-58rqc0cg	20	28	nearly	nearly	RB
cord-016187-58rqc0cg	20	29	800	800	CD
cord-016187-58rqc0cg	20	30	deaths	death	NNS
cord-016187-58rqc0cg	20	31	in	in	IN
cord-016187-58rqc0cg	20	32	early	early	JJ
cord-016187-58rqc0cg	20	33	2003	2003	CD
cord-016187-58rqc0cg	20	34	[	[	-LRB-
cord-016187-58rqc0cg	20	35	9	9	CD
cord-016187-58rqc0cg	20	36	]	]	-RRB-
cord-016187-58rqc0cg	20	37	.	.	.
cord-016187-58rqc0cg	21	1	Through	through	IN
cord-016187-58rqc0cg	21	2	a	a	DT
cord-016187-58rqc0cg	21	3	global	global	JJ
cord-016187-58rqc0cg	21	4	effort	effort	NN
cord-016187-58rqc0cg	21	5	from	from	IN
cord-016187-58rqc0cg	21	6	a	a	DT
cord-016187-58rqc0cg	21	7	large	large	JJ
cord-016187-58rqc0cg	21	8	number	number	NN
cord-016187-58rqc0cg	21	9	of	of	IN
cord-016187-58rqc0cg	21	10	very	very	RB
cord-016187-58rqc0cg	21	11	diligent	diligent	JJ
cord-016187-58rqc0cg	21	12	public	public	JJ
cord-016187-58rqc0cg	21	13	health	health	NN
cord-016187-58rqc0cg	21	14	offi	offi	NNP
cord-016187-58rqc0cg	21	15	cials	cials	NNP
cord-016187-58rqc0cg	21	16	and	and	CC
cord-016187-58rqc0cg	21	17	laboratory	laboratory	NN
cord-016187-58rqc0cg	21	18	scientists	scientist	NNS
cord-016187-58rqc0cg	21	19	,	,	,
cord-016187-58rqc0cg	21	20	the	the	DT
cord-016187-58rqc0cg	21	21	outbreak	outbreak	NN
cord-016187-58rqc0cg	21	22	ended	end	VBD
cord-016187-58rqc0cg	21	23	within	within	IN
cord-016187-58rqc0cg	21	24	a	a	DT
cord-016187-58rqc0cg	21	25	year	year	NN
cord-016187-58rqc0cg	21	26	and	and	CC
cord-016187-58rqc0cg	21	27	has	have	VBZ
cord-016187-58rqc0cg	21	28	yet	yet	RB
cord-016187-58rqc0cg	21	29	to	to	TO
cord-016187-58rqc0cg	21	30	be	be	VB
cord-016187-58rqc0cg	21	31	seen	see	VBN
cord-016187-58rqc0cg	21	32	again	again	RB
cord-016187-58rqc0cg	21	33	,	,	,
cord-016187-58rqc0cg	21	34	except	except	IN
cord-016187-58rqc0cg	21	35	for	for	IN
cord-016187-58rqc0cg	21	36	occasional	occasional	JJ
cord-016187-58rqc0cg	21	37	laboratory	laboratory	NN
cord-016187-58rqc0cg	21	38	-	-	HYPH
cord-016187-58rqc0cg	21	39	acquired	acquire	VBN
cord-016187-58rqc0cg	21	40	accidents	accident	NNS
cord-016187-58rqc0cg	21	41	[	[	-LRB-
cord-016187-58rqc0cg	21	42	9	9	CD
cord-016187-58rqc0cg	21	43	]	]	-RRB-
cord-016187-58rqc0cg	21	44	.	.	.
cord-016187-58rqc0cg	22	1	A	a	DT
cord-016187-58rqc0cg	22	2	diverse	diverse	JJ
cord-016187-58rqc0cg	22	3	array	array	NN
cord-016187-58rqc0cg	22	4	of	of	IN
cord-016187-58rqc0cg	22	5	pathogens	pathogen	NNS
cord-016187-58rqc0cg	22	6	has	have	VBZ
cord-016187-58rqc0cg	22	7	produced	produce	VBN
cord-016187-58rqc0cg	22	8	recent	recent	JJ
cord-016187-58rqc0cg	22	9	outbreaks	outbreak	NNS
cord-016187-58rqc0cg	22	10	and	and	CC
cord-016187-58rqc0cg	22	11	concerns	concern	NNS
cord-016187-58rqc0cg	22	12	for	for	IN
cord-016187-58rqc0cg	22	13	our	-PRON-	PRP$
cord-016187-58rqc0cg	22	14	vulnerability	vulnerability	NN
cord-016187-58rqc0cg	22	15	to	to	IN
cord-016187-58rqc0cg	22	16	pathogens	pathogen	NNS
cord-016187-58rqc0cg	22	17	within	within	IN
cord-016187-58rqc0cg	22	18	the	the	DT
cord-016187-58rqc0cg	22	19	global	global	JJ
cord-016187-58rqc0cg	22	20	village	village	NN
cord-016187-58rqc0cg	22	21	we	-PRON-	PRP
cord-016187-58rqc0cg	22	22	occupy	occupy	VBP
cord-016187-58rqc0cg	22	23	and	and	CC
cord-016187-58rqc0cg	22	24	share	share	VBP
cord-016187-58rqc0cg	22	25	with	with	IN
cord-016187-58rqc0cg	22	26	other	other	JJ
cord-016187-58rqc0cg	22	27	fl	fl	NNP
cord-016187-58rqc0cg	22	28	ora	ora	NN
cord-016187-58rqc0cg	22	29	,	,	,
cord-016187-58rqc0cg	22	30	fauna	fauna	NNS
cord-016187-58rqc0cg	22	31	and	and	CC
cord-016187-58rqc0cg	22	32	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	22	33	(	(	-LRB-
cord-016187-58rqc0cg	22	34	Table	table	NN
cord-016187-58rqc0cg	22	35	1	1	CD
cord-016187-58rqc0cg	22	36	)	)	-RRB-
cord-016187-58rqc0cg	22	37	.	.	.
cord-016187-58rqc0cg	23	1	The	the	DT
cord-016187-58rqc0cg	23	2	spread	spread	NN
cord-016187-58rqc0cg	23	3	of	of	IN
cord-016187-58rqc0cg	23	4	mosquito-	mosquito-	JJ
cord-016187-58rqc0cg	23	5	Avian	avian	JJ
cord-016187-58rqc0cg	23	6	infl	infl	NN
cord-016187-58rqc0cg	23	7	uenza	uenza	NN
cord-016187-58rqc0cg	23	8	[	[	-LRB-
cord-016187-58rqc0cg	23	9	4	4	CD
cord-016187-58rqc0cg	23	10	]	]	-RRB-
cord-016187-58rqc0cg	23	11	[	[	-LRB-
cord-016187-58rqc0cg	23	12	5	5	CD
cord-016187-58rqc0cg	23	13	]	]	-RRB-
cord-016187-58rqc0cg	23	14	[	[	-LRB-
cord-016187-58rqc0cg	23	15	6	6	CD
cord-016187-58rqc0cg	23	16	]	]	-RRB-
cord-016187-58rqc0cg	23	17	[	[	-LRB-
cord-016187-58rqc0cg	23	18	7	7	CD
cord-016187-58rqc0cg	23	19	]	]	-RRB-
cord-016187-58rqc0cg	24	1	Infl	Infl	NNP
cord-016187-58rqc0cg	24	2	uenza	uenza	NNP
cord-016187-58rqc0cg	24	3	A	a	NN
cord-016187-58rqc0cg	25	1	(	(	-LRB-
cord-016187-58rqc0cg	25	2	H	h	NN
cord-016187-58rqc0cg	25	3	5	5	CD
cord-016187-58rqc0cg	25	4	N	n	CD
cord-016187-58rqc0cg	25	5	1	1	CD
cord-016187-58rqc0cg	25	6	)	)	-RRB-
cord-016187-58rqc0cg	25	7	Risk	risk	NN
cord-016187-58rqc0cg	25	8	of	of	IN
cord-016187-58rqc0cg	25	9	pandemic	pandemic	NN
cord-016187-58rqc0cg	25	10	infl	infl	XX
cord-016187-58rqc0cg	25	11	uenza	uenza	NNP
cord-016187-58rqc0cg	25	12	;	;	,
cord-016187-58rqc0cg	25	13	sporadic	sporadic	JJ
cord-016187-58rqc0cg	25	14	human	human	JJ
cord-016187-58rqc0cg	25	15	cases	case	NNS
cord-016187-58rqc0cg	25	16	of	of	IN
cord-016187-58rqc0cg	25	17	avian	avian	JJ
cord-016187-58rqc0cg	25	18	fl	fl	NNP
cord-016187-58rqc0cg	25	19	u	u	NNP
cord-016187-58rqc0cg	25	20	in	in	IN
cord-016187-58rqc0cg	25	21	Asia	Asia	NNP
cord-016187-58rqc0cg	26	1	-mortality	-mortality	:
cord-016187-58rqc0cg	26	2	rates>70	rates>70	NNP
cord-016187-58rqc0cg	26	3	%	%	NN
cord-016187-58rqc0cg	26	4	Severe	severe	JJ
cord-016187-58rqc0cg	26	5	acute	acute	JJ
cord-016187-58rqc0cg	26	6	SARS	SARS	NNP
cord-016187-58rqc0cg	26	7	associated	associate	VBD
cord-016187-58rqc0cg	26	8	coronavirus	coronavirus	NN
cord-016187-58rqc0cg	26	9	Risk	risk	NN
cord-016187-58rqc0cg	26	10	of	of	IN
cord-016187-58rqc0cg	26	11	spread	spread	NN
cord-016187-58rqc0cg	26	12	of	of	IN
cord-016187-58rqc0cg	26	13	zoonotic	zoonotic	JJ
cord-016187-58rqc0cg	26	14	respiratory	respiratory	JJ
cord-016187-58rqc0cg	26	15	syndrome	syndrome	NN
cord-016187-58rqc0cg	26	16	viruses	virus	NNS
cord-016187-58rqc0cg	26	17	;	;	:
cord-016187-58rqc0cg	26	18	outbreak	outbreak	NN
cord-016187-58rqc0cg	26	19	from	from	IN
cord-016187-58rqc0cg	26	20	a	a	DT
cord-016187-58rqc0cg	26	21	(	(	-LRB-
cord-016187-58rqc0cg	26	22	SARS	SARS	NNP
cord-016187-58rqc0cg	26	23	)	)	-RRB-
cord-016187-58rqc0cg	26	24	[	[	-LRB-
cord-016187-58rqc0cg	26	25	8	8	CD
cord-016187-58rqc0cg	26	26	]	]	-RRB-
cord-016187-58rqc0cg	26	27	[	[	-LRB-
cord-016187-58rqc0cg	26	28	9	9	CD
cord-016187-58rqc0cg	26	29	]	]	-RRB-
cord-016187-58rqc0cg	26	30	[	[	-LRB-
cord-016187-58rqc0cg	26	31	10	10	CD
cord-016187-58rqc0cg	26	32	]	]	-RRB-
cord-016187-58rqc0cg	26	33	southern	southern	JJ
cord-016187-58rqc0cg	26	34	China	China	NNP
cord-016187-58rqc0cg	26	35	to	to	IN
cord-016187-58rqc0cg	26	36	worldwide	worldwide	JJ
cord-016187-58rqc0cg	26	37	epidemic	epidemic	NN
cord-016187-58rqc0cg	26	38	in	in	IN
cord-016187-58rqc0cg	26	39	2003	2003	CD
cord-016187-58rqc0cg	26	40	-8000	-8000	NN
cord-016187-58rqc0cg	26	41	cases	case	NNS
cord-016187-58rqc0cg	26	42	and	and	CC
cord-016187-58rqc0cg	26	43	800	800	CD
cord-016187-58rqc0cg	26	44	deaths	death	NNS
cord-016187-58rqc0cg	26	45	Monkey	Monkey	NNP
cord-016187-58rqc0cg	26	46	pox	pox	NN
cord-016187-58rqc0cg	26	47	[	[	-LRB-
cord-016187-58rqc0cg	26	48	11	11	CD
cord-016187-58rqc0cg	26	49	]	]	-RRB-
cord-016187-58rqc0cg	26	50	Orthopox	Orthopox	NNP
cord-016187-58rqc0cg	26	51	virus	virus	NN
cord-016187-58rqc0cg	26	52	Risk	risk	NN
cord-016187-58rqc0cg	26	53	of	of	IN
cord-016187-58rqc0cg	26	54	exotic	exotic	JJ
cord-016187-58rqc0cg	26	55	pet	pet	JJ
cord-016187-58rqc0cg	26	56	trade	trade	NN
cord-016187-58rqc0cg	26	57	;	;	:
cord-016187-58rqc0cg	26	58	outbreak	outbreak	NN
cord-016187-58rqc0cg	26	59	in	in	IN
cord-016187-58rqc0cg	26	60	wild	wild	JJ
cord-016187-58rqc0cg	26	61	rodents	rodent	NNS
cord-016187-58rqc0cg	26	62	and	and	CC
cord-016187-58rqc0cg	26	63	humans	human	NNS
cord-016187-58rqc0cg	26	64	in	in	IN
cord-016187-58rqc0cg	26	65	Mid	mid	JJ
cord-016187-58rqc0cg	26	66	-	-	JJ
cord-016187-58rqc0cg	26	67	Western	western	JJ
cord-016187-58rqc0cg	26	68	USA	USA	NNP
cord-016187-58rqc0cg	26	69	from	from	IN
cord-016187-58rqc0cg	26	70	sale	sale	NN
cord-016187-58rqc0cg	26	71	of	of	IN
cord-016187-58rqc0cg	26	72	Gambian	gambian	JJ
cord-016187-58rqc0cg	26	73	Giant	Giant	NNP
cord-016187-58rqc0cg	26	74	rats	rat	NNS
cord-016187-58rqc0cg	26	75	from	from	IN
cord-016187-58rqc0cg	26	76	Africa	Africa	NNP
cord-016187-58rqc0cg	26	77	West	West	NNP
cord-016187-58rqc0cg	26	78	Nile	Nile	NNP
cord-016187-58rqc0cg	26	79	Virus	Virus	NNP
cord-016187-58rqc0cg	26	80	Mosquito	Mosquito	NNP
cord-016187-58rqc0cg	26	81	-	-	:
cord-016187-58rqc0cg	26	82	borne	bear	VBN
cord-016187-58rqc0cg	26	83	fl	fl	NNP
cord-016187-58rqc0cg	26	84	avivirus	avivirus	NNP
cord-016187-58rqc0cg	26	85	Risk	Risk	NNP
cord-016187-58rqc0cg	26	86	of	of	IN
cord-016187-58rqc0cg	26	87	international	international	JJ
cord-016187-58rqc0cg	26	88	spread	spread	NN
cord-016187-58rqc0cg	26	89	;	;	:
cord-016187-58rqc0cg	26	90	(	(	-LRB-
cord-016187-58rqc0cg	26	91	WNV	WNV	NNP
cord-016187-58rqc0cg	26	92	)	)	-RRB-
cord-016187-58rqc0cg	27	1	[	[	-LRB-
cord-016187-58rqc0cg	27	2	12	12	CD
cord-016187-58rqc0cg	27	3	,	,	,
cord-016187-58rqc0cg	27	4	13	13	CD
cord-016187-58rqc0cg	27	5	]	]	-RRB-
cord-016187-58rqc0cg	27	6	WNV	WNV	NNP
cord-016187-58rqc0cg	27	7	from	from	IN
cord-016187-58rqc0cg	27	8	Africa	Africa	NNP
cord-016187-58rqc0cg	27	9	to	to	IN
cord-016187-58rqc0cg	27	10	New	New	NNP
cord-016187-58rqc0cg	27	11	York	York	NNP
cord-016187-58rqc0cg	27	12	in	in	IN
cord-016187-58rqc0cg	27	13	1999	1999	CD
cord-016187-58rqc0cg	27	14	,	,	,
cord-016187-58rqc0cg	27	15	thousands	thousand	NNS
cord-016187-58rqc0cg	27	16	of	of	IN
cord-016187-58rqc0cg	27	17	cases	case	NNS
cord-016187-58rqc0cg	27	18	and	and	CC
cord-016187-58rqc0cg	27	19	hundreds	hundred	NNS
cord-016187-58rqc0cg	27	20	of	of	IN
cord-016187-58rqc0cg	27	21	deaths	death	NNS
cord-016187-58rqc0cg	27	22	in	in	IN
cord-016187-58rqc0cg	27	23	North	North	NNP
cord-016187-58rqc0cg	27	24	America	America	NNP
cord-016187-58rqc0cg	27	25	over	over	IN
cord-016187-58rqc0cg	27	26	next	next	JJ
cord-016187-58rqc0cg	27	27	5	5	CD
cord-016187-58rqc0cg	27	28	years	year	NNS
cord-016187-58rqc0cg	27	29	Inhalational	Inhalational	NNP
cord-016187-58rqc0cg	27	30	anthrax	anthrax	NN
cord-016187-58rqc0cg	27	31	Intentional	intentional	JJ
cord-016187-58rqc0cg	27	32	release	release	NN
cord-016187-58rqc0cg	27	33	of	of	IN
cord-016187-58rqc0cg	27	34	Vulnerability	vulnerability	NN
cord-016187-58rqc0cg	27	35	to	to	IN
cord-016187-58rqc0cg	27	36	[	[	-LRB-
cord-016187-58rqc0cg	27	37	14	14	CD
cord-016187-58rqc0cg	27	38	,	,	,
cord-016187-58rqc0cg	27	39	15	15	CD
cord-016187-58rqc0cg	27	40	]	]	-RRB-
cord-016187-58rqc0cg	28	1	Bacillus	bacillus	NN
cord-016187-58rqc0cg	28	2	anthracis	anthracis	NN
cord-016187-58rqc0cg	28	3	spores	spore	VBZ
cord-016187-58rqc0cg	28	4	bioterrorism	bioterrorism	NN
cord-016187-58rqc0cg	28	5	;	;	:
cord-016187-58rqc0cg	28	6	11	11	CD
cord-016187-58rqc0cg	28	7	cases	case	NNS
cord-016187-58rqc0cg	28	8	,	,	,
cord-016187-58rqc0cg	28	9	in	in	IN
cord-016187-58rqc0cg	28	10	USA	USA	NNP
cord-016187-58rqc0cg	28	11	mail	mail	NN
cord-016187-58rqc0cg	28	12	system	system	NN
cord-016187-58rqc0cg	28	13	5	5	CD
cord-016187-58rqc0cg	28	14	[	[	-LRB-
cord-016187-58rqc0cg	28	15	17	17	CD
cord-016187-58rqc0cg	28	16	]	]	-RRB-
cord-016187-58rqc0cg	28	17	[	[	-LRB-
cord-016187-58rqc0cg	28	18	18	18	CD
cord-016187-58rqc0cg	28	19	]	]	-RRB-
cord-016187-58rqc0cg	28	20	[	[	-LRB-
cord-016187-58rqc0cg	28	21	19	19	CD
cord-016187-58rqc0cg	28	22	]	]	-RRB-
cord-016187-58rqc0cg	28	23	[	[	-LRB-
cord-016187-58rqc0cg	28	24	20	20	CD
cord-016187-58rqc0cg	28	25	]	]	-RRB-
cord-016187-58rqc0cg	28	26	Oseltamivir	Oseltamivir	NNP
cord-016187-58rqc0cg	28	27	-	-	HYPH
cord-016187-58rqc0cg	28	28	resistant	resistant	JJ
cord-016187-58rqc0cg	28	29	infl	infl	NN
cord-016187-58rqc0cg	28	30	uenza	uenza	NN
cord-016187-58rqc0cg	28	31	genes	gene	NNS
cord-016187-58rqc0cg	29	1	-community	-community	:
cord-016187-58rqc0cg	30	1	Azole	Azole	NNP
cord-016187-58rqc0cg	30	2	-	-	HYPH
cord-016187-58rqc0cg	30	3	resistant	resistant	JJ
cord-016187-58rqc0cg	30	4	outbreaks	outbreak	NNS
cord-016187-58rqc0cg	30	5	now	now	RB
cord-016187-58rqc0cg	30	6	occur	occur	VBP
cord-016187-58rqc0cg	30	7	Candida	Candida	NNP
cord-016187-58rqc0cg	30	8	spp	spp	NNS
cord-016187-58rqc0cg	30	9	.	.	.
cord-016187-58rqc0cg	31	1	borne	borne	NNP
cord-016187-58rqc0cg	31	2	West	West	NNP
cord-016187-58rqc0cg	31	3	Nile	Nile	NNP
cord-016187-58rqc0cg	31	4	virus	virus	NN
cord-016187-58rqc0cg	31	5	in	in	IN
cord-016187-58rqc0cg	31	6	North	North	NNP
cord-016187-58rqc0cg	31	7	America	America	NNP
cord-016187-58rqc0cg	31	8	[	[	-LRB-
cord-016187-58rqc0cg	31	9	12	12	CD
cord-016187-58rqc0cg	31	10	,	,	,
cord-016187-58rqc0cg	31	11	13	13	CD
cord-016187-58rqc0cg	31	12	]	]	-RRB-
cord-016187-58rqc0cg	32	1	,	,	,
cord-016187-58rqc0cg	32	2	prion	prion	NN
cord-016187-58rqc0cg	32	3	-	-	HYPH
cord-016187-58rqc0cg	32	4	related	relate	VBN
cord-016187-58rqc0cg	32	5	food	food	NN
cord-016187-58rqc0cg	32	6	-	-	HYPH
cord-016187-58rqc0cg	32	7	borne	bear	VBN
cord-016187-58rqc0cg	32	8	variant	variant	NN
cord-016187-58rqc0cg	32	9	Creutzfeldt	Creutzfeldt	NNP
cord-016187-58rqc0cg	32	10	-	-	HYPH
cord-016187-58rqc0cg	32	11	Jakob	Jakob	NNP
cord-016187-58rqc0cg	32	12	Disease	Disease	NNP
cord-016187-58rqc0cg	32	13	[	[	-LRB-
cord-016187-58rqc0cg	32	14	21	21	CD
cord-016187-58rqc0cg	32	15	]	]	-RRB-
cord-016187-58rqc0cg	32	16	,	,	,
cord-016187-58rqc0cg	32	17	and	and	CC
cord-016187-58rqc0cg	32	18	hemorrhagic	hemorrhagic	JJ
cord-016187-58rqc0cg	32	19	fever	fever	NN
cord-016187-58rqc0cg	32	20	viruses	virus	NNS
cord-016187-58rqc0cg	32	21	[	[	-LRB-
cord-016187-58rqc0cg	32	22	16	16	CD
cord-016187-58rqc0cg	32	23	]	]	-RRB-
cord-016187-58rqc0cg	32	24	are	be	VBP
cord-016187-58rqc0cg	32	25	a	a	DT
cord-016187-58rqc0cg	32	26	constant	constant	JJ
cord-016187-58rqc0cg	32	27	reminder	reminder	NN
cord-016187-58rqc0cg	32	28	of	of	IN
cord-016187-58rqc0cg	32	29	our	-PRON-	PRP$
cord-016187-58rqc0cg	32	30	susceptibility	susceptibility	NN
cord-016187-58rqc0cg	32	31	to	to	IN
cord-016187-58rqc0cg	32	32	pathogens	pathogen	NNS
cord-016187-58rqc0cg	32	33	that	that	WDT
cord-016187-58rqc0cg	32	34	naturally	naturally	RB
cord-016187-58rqc0cg	32	35	reside	reside	VBP
cord-016187-58rqc0cg	32	36	in	in	IN
cord-016187-58rqc0cg	32	37	other	other	JJ
cord-016187-58rqc0cg	32	38	animal	animal	NN
cord-016187-58rqc0cg	32	39	species	specie	NNS
cord-016187-58rqc0cg	32	40	.	.	.
cord-016187-58rqc0cg	33	1	The	the	DT
cord-016187-58rqc0cg	33	2	omnipresent	omnipresent	JJ
cord-016187-58rqc0cg	33	3	fear	fear	NN
cord-016187-58rqc0cg	33	4	of	of	IN
cord-016187-58rqc0cg	33	5	the	the	DT
cord-016187-58rqc0cg	33	6	next	next	JJ
cord-016187-58rqc0cg	33	7	pandemic	pandemic	NN
cord-016187-58rqc0cg	33	8	of	of	IN
cord-016187-58rqc0cg	33	9	infl	infl	NN
cord-016187-58rqc0cg	33	10	uenza	uenza	NNP
cord-016187-58rqc0cg	33	11	has	have	VBZ
cord-016187-58rqc0cg	33	12	been	be	VBN
cord-016187-58rqc0cg	33	13	heightened	heighten	VBN
cord-016187-58rqc0cg	33	14	by	by	IN
cord-016187-58rqc0cg	33	15	recent	recent	JJ
cord-016187-58rqc0cg	33	16	evolutionary	evolutionary	JJ
cord-016187-58rqc0cg	33	17	changes	change	NNS
cord-016187-58rqc0cg	33	18	in	in	IN
cord-016187-58rqc0cg	33	19	virulence	virulence	NN
cord-016187-58rqc0cg	33	20	and	and	CC
cord-016187-58rqc0cg	33	21	transmissibility	transmissibility	NN
cord-016187-58rqc0cg	33	22	of	of	IN
cord-016187-58rqc0cg	33	23	avian	avian	JJ
cord-016187-58rqc0cg	33	24	fl	fl	NNP
cord-016187-58rqc0cg	33	25	u	u	NNP
cord-016187-58rqc0cg	33	26	viruses	virus	NNS
cord-016187-58rqc0cg	33	27	[	[	-LRB-
cord-016187-58rqc0cg	33	28	22	22	CD
cord-016187-58rqc0cg	33	29	]	]	-RRB-
cord-016187-58rqc0cg	33	30	.	.	.
cord-016187-58rqc0cg	34	1	Standard	standard	JJ
cord-016187-58rqc0cg	34	2	chemotherapeutic	chemotherapeutic	JJ
cord-016187-58rqc0cg	34	3	regimens	regimen	NNS
cord-016187-58rqc0cg	34	4	for	for	IN
cord-016187-58rqc0cg	34	5	infectious	infectious	JJ
cord-016187-58rqc0cg	34	6	diseases	disease	NNS
cord-016187-58rqc0cg	34	7	may	may	MD
cord-016187-58rqc0cg	34	8	not	not	RB
cord-016187-58rqc0cg	34	9	reliably	reliably	RB
cord-016187-58rqc0cg	34	10	rescue	rescue	VB
cord-016187-58rqc0cg	34	11	persons	person	NNS
cord-016187-58rqc0cg	34	12	with	with	IN
cord-016187-58rqc0cg	34	13	severe	severe	JJ
cord-016187-58rqc0cg	34	14	infections	infection	NNS
cord-016187-58rqc0cg	34	15	in	in	IN
cord-016187-58rqc0cg	34	16	the	the	DT
cord-016187-58rqc0cg	34	17	new	new	JJ
cord-016187-58rqc0cg	34	18	millennium	millennium	NN
cord-016187-58rqc0cg	34	19	.	.	.
cord-016187-58rqc0cg	35	1	Community	community	NN
cord-016187-58rqc0cg	35	2	and	and	CC
cord-016187-58rqc0cg	35	3	nosocomial	nosocomial	JJ
cord-016187-58rqc0cg	35	4	outbreaks	outbreak	NNS
cord-016187-58rqc0cg	35	5	of	of	IN
cord-016187-58rqc0cg	35	6	multidrug	multidrug	NN
cord-016187-58rqc0cg	35	7	resistant	resistant	JJ
cord-016187-58rqc0cg	35	8	pathogens	pathogen	NNS
cord-016187-58rqc0cg	35	9	as	as	IN
cord-016187-58rqc0cg	35	10	evidenced	evidence	VBN
cord-016187-58rqc0cg	35	11	by	by	IN
cord-016187-58rqc0cg	35	12	methicillin	methicillin	NN
cord-016187-58rqc0cg	35	13	and	and	CC
cord-016187-58rqc0cg	35	14	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	35	15	resistance	resistance	NN
cord-016187-58rqc0cg	35	16	[	[	-LRB-
cord-016187-58rqc0cg	35	17	17	17	CD
cord-016187-58rqc0cg	35	18	]	]	-RRB-
cord-016187-58rqc0cg	35	19	in	in	IN
cord-016187-58rqc0cg	35	20	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	35	21	aureus	aureus	NN
cord-016187-58rqc0cg	35	22	and	and	CC
cord-016187-58rqc0cg	35	23	resistance	resistance	NN
cord-016187-58rqc0cg	35	24	to	to	IN
cord-016187-58rqc0cg	35	25	the	the	DT
cord-016187-58rqc0cg	35	26	new	new	JJ
cord-016187-58rqc0cg	35	27	anti	anti	JJ
cord-016187-58rqc0cg	35	28	-	-	JJ
cord-016187-58rqc0cg	35	29	viral	viral	JJ
cord-016187-58rqc0cg	35	30	neuraminidase	neuraminidase	NN
cord-016187-58rqc0cg	35	31	inhibitors	inhibitor	NNS
cord-016187-58rqc0cg	35	32	[	[	-LRB-
cord-016187-58rqc0cg	35	33	18	18	CD
cord-016187-58rqc0cg	35	34	,	,	,
cord-016187-58rqc0cg	35	35	19	19	CD
cord-016187-58rqc0cg	35	36	]	]	-RRB-
cord-016187-58rqc0cg	35	37	by	by	IN
cord-016187-58rqc0cg	35	38	recent	recent	JJ
cord-016187-58rqc0cg	35	39	infl	infl	NN
cord-016187-58rqc0cg	35	40	uenza	uenza	NN
cord-016187-58rqc0cg	35	41	isolates	isolate	NNS
cord-016187-58rqc0cg	35	42	are	be	VBP
cord-016187-58rqc0cg	35	43	cause	cause	NN
cord-016187-58rqc0cg	35	44	for	for	IN
cord-016187-58rqc0cg	35	45	real	real	JJ
cord-016187-58rqc0cg	35	46	concern	concern	NN
cord-016187-58rqc0cg	35	47	.	.	.
cord-016187-58rqc0cg	36	1	The	the	DT
cord-016187-58rqc0cg	36	2	care	care	NN
cord-016187-58rqc0cg	36	3	of	of	IN
cord-016187-58rqc0cg	36	4	hospitalized	hospitalize	VBN
cord-016187-58rqc0cg	36	5	,	,	,
cord-016187-58rqc0cg	36	6	critically	critically	RB
cord-016187-58rqc0cg	36	7	ill	ill	JJ
cord-016187-58rqc0cg	36	8	patients	patient	NNS
cord-016187-58rqc0cg	36	9	is	be	VBZ
cord-016187-58rqc0cg	36	10	likely	likely	JJ
cord-016187-58rqc0cg	36	11	to	to	TO
cord-016187-58rqc0cg	36	12	fundamentally	fundamentally	RB
cord-016187-58rqc0cg	36	13	change	change	VB
cord-016187-58rqc0cg	36	14	if	if	IN
cord-016187-58rqc0cg	36	15	current	current	JJ
cord-016187-58rqc0cg	36	16	trends	trend	NNS
cord-016187-58rqc0cg	36	17	in	in	IN
cord-016187-58rqc0cg	36	18	the	the	DT
cord-016187-58rqc0cg	36	19	progressive	progressive	JJ
cord-016187-58rqc0cg	36	20	emergence	emergence	NN
cord-016187-58rqc0cg	36	21	of	of	IN
cord-016187-58rqc0cg	36	22	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	36	23	resistance	resistance	NN
cord-016187-58rqc0cg	36	24	to	to	TO
cord-016187-58rqc0cg	36	25	commonly	commonly	RB
cord-016187-58rqc0cg	36	26	prescribed	prescribe	VBN
cord-016187-58rqc0cg	36	27	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	36	28	are	be	VBP
cord-016187-58rqc0cg	36	29	not	not	RB
cord-016187-58rqc0cg	36	30	signifi	signifi	NNP
cord-016187-58rqc0cg	36	31	cantly	cantly	RB
cord-016187-58rqc0cg	36	32	altered	alter	VBN
cord-016187-58rqc0cg	36	33	in	in	IN
cord-016187-58rqc0cg	36	34	the	the	DT
cord-016187-58rqc0cg	36	35	near	near	JJ
cord-016187-58rqc0cg	36	36	future	future	NN
cord-016187-58rqc0cg	36	37	.	.	.
cord-016187-58rqc0cg	37	1	Regrettably	regrettably	RB
cord-016187-58rqc0cg	37	2	,	,	,
cord-016187-58rqc0cg	37	3	there	there	EX
cord-016187-58rqc0cg	37	4	is	be	VBZ
cord-016187-58rqc0cg	37	5	little	little	JJ
cord-016187-58rqc0cg	37	6	evidence	evidence	NN
cord-016187-58rqc0cg	37	7	that	that	IN
cord-016187-58rqc0cg	37	8	the	the	DT
cord-016187-58rqc0cg	37	9	situation	situation	NN
cord-016187-58rqc0cg	37	10	is	be	VBZ
cord-016187-58rqc0cg	37	11	likely	likely	JJ
cord-016187-58rqc0cg	37	12	to	to	TO
cord-016187-58rqc0cg	37	13	change	change	VB
cord-016187-58rqc0cg	37	14	unless	unless	IN
cord-016187-58rqc0cg	37	15	concerted	concerted	JJ
cord-016187-58rqc0cg	37	16	efforts	effort	NNS
cord-016187-58rqc0cg	37	17	are	be	VBP
cord-016187-58rqc0cg	37	18	taken	take	VBN
cord-016187-58rqc0cg	37	19	on	on	IN
cord-016187-58rqc0cg	37	20	several	several	JJ
cord-016187-58rqc0cg	37	21	fronts	front	NNS
cord-016187-58rqc0cg	37	22	to	to	TO
cord-016187-58rqc0cg	37	23	reverse	reverse	VB
cord-016187-58rqc0cg	37	24	the	the	DT
cord-016187-58rqc0cg	37	25	current	current	JJ
cord-016187-58rqc0cg	37	26	trajectory	trajectory	NN
cord-016187-58rqc0cg	37	27	of	of	IN
cord-016187-58rqc0cg	37	28	increasing	increase	VBG
cord-016187-58rqc0cg	37	29	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	37	30	resistance	resistance	NN
cord-016187-58rqc0cg	37	31	[	[	-LRB-
cord-016187-58rqc0cg	37	32	17	17	CD
cord-016187-58rqc0cg	37	33	,	,	,
cord-016187-58rqc0cg	37	34	20	20	CD
cord-016187-58rqc0cg	37	35	]	]	-RRB-
cord-016187-58rqc0cg	37	36	.	.	.
cord-016187-58rqc0cg	38	1	The	the	DT
cord-016187-58rqc0cg	38	2	fi	fi	NN
cord-016187-58rqc0cg	38	3	tness	tness	NN
cord-016187-58rqc0cg	38	4	of	of	IN
cord-016187-58rqc0cg	38	5	a	a	DT
cord-016187-58rqc0cg	38	6	microorganism	microorganism	NN
cord-016187-58rqc0cg	38	7	is	be	VBZ
cord-016187-58rqc0cg	38	8	dependent	dependent	JJ
cord-016187-58rqc0cg	38	9	upon	upon	IN
cord-016187-58rqc0cg	38	10	its	-PRON-	PRP$
cord-016187-58rqc0cg	38	11	capacity	capacity	NN
cord-016187-58rqc0cg	38	12	to	to	TO
cord-016187-58rqc0cg	38	13	genetically	genetically	RB
cord-016187-58rqc0cg	38	14	adapt	adapt	VB
cord-016187-58rqc0cg	38	15	to	to	TO
cord-016187-58rqc0cg	38	16	rapidly	rapidly	RB
cord-016187-58rqc0cg	38	17	changing	change	VBG
cord-016187-58rqc0cg	38	18	environmental	environmental	JJ
cord-016187-58rqc0cg	38	19	conditions	condition	NNS
cord-016187-58rqc0cg	38	20	.	.	.
cord-016187-58rqc0cg	39	1	Antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	39	2	agents	agent	NNS
cord-016187-58rqc0cg	39	3	exert	exert	VBP
cord-016187-58rqc0cg	39	4	strong	strong	JJ
cord-016187-58rqc0cg	39	5	selective	selective	JJ
cord-016187-58rqc0cg	39	6	pressures	pressure	NNS
cord-016187-58rqc0cg	39	7	on	on	IN
cord-016187-58rqc0cg	39	8	microbial	microbial	JJ
cord-016187-58rqc0cg	39	9	populations	population	NNS
cord-016187-58rqc0cg	39	10	,	,	,
cord-016187-58rqc0cg	39	11	favoring	favor	VBG
cord-016187-58rqc0cg	39	12	those	those	DT
cord-016187-58rqc0cg	39	13	organisms	organism	NNS
cord-016187-58rqc0cg	39	14	that	that	WDT
cord-016187-58rqc0cg	39	15	are	be	VBP
cord-016187-58rqc0cg	39	16	capable	capable	JJ
cord-016187-58rqc0cg	39	17	of	of	IN
cord-016187-58rqc0cg	39	18	resisting	resist	VBG
cord-016187-58rqc0cg	39	19	them	-PRON-	PRP
cord-016187-58rqc0cg	39	20	.	.	.
cord-016187-58rqc0cg	40	1	Genetic	genetic	JJ
cord-016187-58rqc0cg	40	2	variability	variability	NN
cord-016187-58rqc0cg	40	3	may	may	MD
cord-016187-58rqc0cg	40	4	occur	occur	VB
cord-016187-58rqc0cg	40	5	by	by	IN
cord-016187-58rqc0cg	40	6	a	a	DT
cord-016187-58rqc0cg	40	7	variety	variety	NN
cord-016187-58rqc0cg	40	8	of	of	IN
cord-016187-58rqc0cg	40	9	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	40	10	.	.	.
cord-016187-58rqc0cg	41	1	Point	point	NN
cord-016187-58rqc0cg	41	2	mutations	mutation	NNS
cord-016187-58rqc0cg	41	3	may	may	MD
cord-016187-58rqc0cg	41	4	occur	occur	VB
cord-016187-58rqc0cg	41	5	in	in	IN
cord-016187-58rqc0cg	41	6	a	a	DT
cord-016187-58rqc0cg	41	7	nucleotide	nucleotide	JJ
cord-016187-58rqc0cg	41	8	base	base	NN
cord-016187-58rqc0cg	41	9	pair	pair	NN
cord-016187-58rqc0cg	41	10	,	,	,
cord-016187-58rqc0cg	41	11	which	which	WDT
cord-016187-58rqc0cg	41	12	is	be	VBZ
cord-016187-58rqc0cg	41	13	referred	refer	VBN
cord-016187-58rqc0cg	41	14	to	to	IN
cord-016187-58rqc0cg	41	15	as	as	IN
cord-016187-58rqc0cg	41	16	micro	micro	JJ
cord-016187-58rqc0cg	41	17	-	-	JJ
cord-016187-58rqc0cg	41	18	evolutionary	evolutionary	JJ
cord-016187-58rqc0cg	41	19	change	change	NN
cord-016187-58rqc0cg	41	20	[	[	-LRB-
cord-016187-58rqc0cg	41	21	23	23	CD
cord-016187-58rqc0cg	41	22	]	]	-RRB-
cord-016187-58rqc0cg	41	23	.	.	.
cord-016187-58rqc0cg	42	1	These	these	DT
cord-016187-58rqc0cg	42	2	mutations	mutation	NNS
cord-016187-58rqc0cg	42	3	may	may	MD
cord-016187-58rqc0cg	42	4	alter	alter	VB
cord-016187-58rqc0cg	42	5	the	the	DT
cord-016187-58rqc0cg	42	6	target	target	NN
cord-016187-58rqc0cg	42	7	site	site	NN
cord-016187-58rqc0cg	42	8	of	of	IN
cord-016187-58rqc0cg	42	9	an	an	DT
cord-016187-58rqc0cg	42	10	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	42	11	agent	agent	NN
cord-016187-58rqc0cg	42	12	,	,	,
cord-016187-58rqc0cg	42	13	altering	alter	VBG
cord-016187-58rqc0cg	42	14	with	with	IN
cord-016187-58rqc0cg	42	15	its	-PRON-	PRP$
cord-016187-58rqc0cg	42	16	inhibitory	inhibitory	JJ
cord-016187-58rqc0cg	42	17	capacity	capacity	NN
cord-016187-58rqc0cg	42	18	.	.	.
cord-016187-58rqc0cg	43	1	Point	point	NN
cord-016187-58rqc0cg	43	2	mutations	mutation	NNS
cord-016187-58rqc0cg	43	3	inside	inside	IN
cord-016187-58rqc0cg	43	4	or	or	CC
cord-016187-58rqc0cg	43	5	adjacent	adjacent	JJ
cord-016187-58rqc0cg	43	6	to	to	IN
cord-016187-58rqc0cg	43	7	the	the	DT
cord-016187-58rqc0cg	43	8	active	active	JJ
cord-016187-58rqc0cg	43	9	sites	site	NNS
cord-016187-58rqc0cg	43	10	of	of	IN
cord-016187-58rqc0cg	43	11	existing	exist	VBG
cord-016187-58rqc0cg	43	12	beta	beta	NN
cord-016187-58rqc0cg	43	13	-	-	HYPH
cord-016187-58rqc0cg	43	14	lactamase	lactamase	NN
cord-016187-58rqc0cg	43	15	genes	gene	NNS
cord-016187-58rqc0cg	43	16	(	(	-LRB-
cord-016187-58rqc0cg	43	17	e.g.	e.g.	RB
cord-016187-58rqc0cg	43	18	,	,	,
cord-016187-58rqc0cg	43	19	genes	gene	NNS
cord-016187-58rqc0cg	43	20	for	for	IN
cord-016187-58rqc0cg	43	21	TEM-1	TEM-1	NNP
cord-016187-58rqc0cg	43	22	,	,	,
cord-016187-58rqc0cg	43	23	SHV-1	SHV-1	NNP
cord-016187-58rqc0cg	43	24	)	)	-RRB-
cord-016187-58rqc0cg	43	25	have	have	VBP
cord-016187-58rqc0cg	43	26	generated	generate	VBN
cord-016187-58rqc0cg	43	27	a	a	DT
cord-016187-58rqc0cg	43	28	remarkable	remarkable	JJ
cord-016187-58rqc0cg	43	29	array	array	NN
cord-016187-58rqc0cg	43	30	of	of	IN
cord-016187-58rqc0cg	43	31	newly	newly	RB
cord-016187-58rqc0cg	43	32	recognized	recognize	VBN
cord-016187-58rqc0cg	43	33	extended	extend	VBN
cord-016187-58rqc0cg	43	34	-	-	HYPH
cord-016187-58rqc0cg	43	35	spectrum	spectrum	NN
cord-016187-58rqc0cg	43	36	beta	beta	NN
cord-016187-58rqc0cg	43	37	-	-	HYPH
cord-016187-58rqc0cg	43	38	lactamases	lactamase	NNS
cord-016187-58rqc0cg	43	39	[	[	-LRB-
cord-016187-58rqc0cg	43	40	23	23	CD
cord-016187-58rqc0cg	43	41	]	]	-RRB-
cord-016187-58rqc0cg	43	42	.	.	.
cord-016187-58rqc0cg	44	1	Beta	beta	NN
cord-016187-58rqc0cg	44	2	-	-	HYPH
cord-016187-58rqc0cg	44	3	lactam	lactam	NN
cord-016187-58rqc0cg	44	4	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	44	5	have	have	VBP
cord-016187-58rqc0cg	44	6	been	be	VBN
cord-016187-58rqc0cg	44	7	known	know	VBN
cord-016187-58rqc0cg	44	8	for	for	IN
cord-016187-58rqc0cg	44	9	almost	almost	RB
cord-016187-58rqc0cg	44	10	80	80	CD
cord-016187-58rqc0cg	44	11	years	year	NNS
cord-016187-58rqc0cg	44	12	and	and	CC
cord-016187-58rqc0cg	44	13	their	-PRON-	PRP$
cord-016187-58rqc0cg	44	14	widespread	widespread	JJ
cord-016187-58rqc0cg	44	15	use	use	NN
cord-016187-58rqc0cg	44	16	has	have	VBZ
cord-016187-58rqc0cg	44	17	created	create	VBN
cord-016187-58rqc0cg	44	18	selection	selection	NN
cord-016187-58rqc0cg	44	19	pressures	pressure	NNS
cord-016187-58rqc0cg	44	20	on	on	IN
cord-016187-58rqc0cg	44	21	bacterial	bacterial	JJ
cord-016187-58rqc0cg	44	22	pathogens	pathogen	NNS
cord-016187-58rqc0cg	44	23	to	to	TO
cord-016187-58rqc0cg	44	24	resist	resist	VB
cord-016187-58rqc0cg	44	25	their	-PRON-	PRP$
cord-016187-58rqc0cg	44	26	inhibitory	inhibitory	JJ
cord-016187-58rqc0cg	44	27	actions	action	NNS
cord-016187-58rqc0cg	44	28	.	.	.
cord-016187-58rqc0cg	45	1	At	at	RB
cord-016187-58rqc0cg	45	2	least	least	RBS
cord-016187-58rqc0cg	45	3	267	267	CD
cord-016187-58rqc0cg	45	4	different	different	JJ
cord-016187-58rqc0cg	45	5	bacterial	bacterial	JJ
cord-016187-58rqc0cg	45	6	enzymes	enzyme	NNS
cord-016187-58rqc0cg	45	7	have	have	VBP
cord-016187-58rqc0cg	45	8	now	now	RB
cord-016187-58rqc0cg	45	9	been	be	VBN
cord-016187-58rqc0cg	45	10	characterized	characterize	VBN
cord-016187-58rqc0cg	46	1	that	that	IN
cord-016187-58rqc0cg	46	2	hydrolyze	hydrolyze	VB
cord-016187-58rqc0cg	46	3	beta	beta	NN
cord-016187-58rqc0cg	46	4	-	-	HYPH
cord-016187-58rqc0cg	46	5	lactam	lactam	NN
cord-016187-58rqc0cg	46	6	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	46	7	[	[	-LRB-
cord-016187-58rqc0cg	46	8	24	24	CD
cord-016187-58rqc0cg	46	9	]	]	-RRB-
cord-016187-58rqc0cg	46	10	.	.	.
cord-016187-58rqc0cg	47	1	The	the	DT
cord-016187-58rqc0cg	47	2	hydrolyzing	hydrolyzing	NN
cord-016187-58rqc0cg	47	3	enzymes	enzyme	NNS
cord-016187-58rqc0cg	47	4	exist	exist	VBP
cord-016187-58rqc0cg	47	5	in	in	IN
cord-016187-58rqc0cg	47	6	four	four	CD
cord-016187-58rqc0cg	47	7	basic	basic	JJ
cord-016187-58rqc0cg	47	8	molecular	molecular	JJ
cord-016187-58rqc0cg	47	9	classes	class	NNS
cord-016187-58rqc0cg	47	10	and	and	CC
cord-016187-58rqc0cg	47	11	are	be	VBP
cord-016187-58rqc0cg	47	12	classifi	classifi	NNP
cord-016187-58rqc0cg	47	13	ed	ed	NNP
cord-016187-58rqc0cg	47	14	as	as	IN
cord-016187-58rqc0cg	47	15	listed	list	VBN
cord-016187-58rqc0cg	47	16	in	in	IN
cord-016187-58rqc0cg	47	17	Table	Table	NNP
cord-016187-58rqc0cg	47	18	2	2	CD
cord-016187-58rqc0cg	47	19	.	.	.
cord-016187-58rqc0cg	48	1	The	the	DT
cord-016187-58rqc0cg	48	2	enzymes	enzyme	NNS
cord-016187-58rqc0cg	48	3	are	be	VBP
cord-016187-58rqc0cg	48	4	either	either	CC
cord-016187-58rqc0cg	48	5	serine	serine	NN
cord-016187-58rqc0cg	48	6	hydrolases	hydrolase	NNS
cord-016187-58rqc0cg	48	7	(	(	-LRB-
cord-016187-58rqc0cg	48	8	class	class	NN
cord-016187-58rqc0cg	48	9	A	A	NNP
cord-016187-58rqc0cg	48	10	,	,	,
cord-016187-58rqc0cg	48	11	C	C	NNP
cord-016187-58rqc0cg	48	12	,	,	,
cord-016187-58rqc0cg	48	13	and	and	CC
cord-016187-58rqc0cg	48	14	D	D	NNP
cord-016187-58rqc0cg	48	15	)	)	-RRB-
cord-016187-58rqc0cg	48	16	or	or	CC
cord-016187-58rqc0cg	48	17	zinc	zinc	NN
cord-016187-58rqc0cg	48	18	containing	contain	VBG
cord-016187-58rqc0cg	48	19	metalloenzymes	metalloenzyme	NNS
cord-016187-58rqc0cg	48	20	with	with	IN
cord-016187-58rqc0cg	48	21	a	a	DT
cord-016187-58rqc0cg	48	22	zinc	zinc	NN
cord-016187-58rqc0cg	48	23	-	-	HYPH
cord-016187-58rqc0cg	48	24	binding	bind	VBG
cord-016187-58rqc0cg	48	25	thiol	thiol	NN
cord-016187-58rqc0cg	48	26	group	group	NN
cord-016187-58rqc0cg	48	27	its	-PRON-	PRP$
cord-016187-58rqc0cg	48	28	active	active	JJ
cord-016187-58rqc0cg	48	29	site	site	NN
cord-016187-58rqc0cg	48	30	(	(	-LRB-
cord-016187-58rqc0cg	48	31	class	class	NN
cord-016187-58rqc0cg	48	32	B	b	NN
cord-016187-58rqc0cg	48	33	enzymes	enzyme	NNS
cord-016187-58rqc0cg	48	34	)	)	-RRB-
cord-016187-58rqc0cg	48	35	.	.	.
cord-016187-58rqc0cg	49	1	The	the	DT
cord-016187-58rqc0cg	49	2	microevolutionary	microevolutionary	JJ
cord-016187-58rqc0cg	49	3	events	event	NNS
cord-016187-58rqc0cg	49	4	that	that	WDT
cord-016187-58rqc0cg	49	5	account	account	VBP
cord-016187-58rqc0cg	49	6	for	for	IN
cord-016187-58rqc0cg	49	7	the	the	DT
cord-016187-58rqc0cg	49	8	differential	differential	JJ
cord-016187-58rqc0cg	49	9	activities	activity	NNS
cord-016187-58rqc0cg	49	10	of	of	IN
cord-016187-58rqc0cg	49	11	this	this	DT
cord-016187-58rqc0cg	49	12	array	array	NN
cord-016187-58rqc0cg	49	13	of	of	IN
cord-016187-58rqc0cg	49	14	beta	beta	NN
cord-016187-58rqc0cg	49	15	-	-	HYPH
cord-016187-58rqc0cg	49	16	lactamases	lactamase	NNS
cord-016187-58rqc0cg	49	17	have	have	VBP
cord-016187-58rqc0cg	49	18	been	be	VBN
cord-016187-58rqc0cg	49	19	carefully	carefully	RB
cord-016187-58rqc0cg	49	20	studied	study	VBN
cord-016187-58rqc0cg	49	21	,	,	,
cord-016187-58rqc0cg	49	22	and	and	CC
cord-016187-58rqc0cg	49	23	these	these	DT
cord-016187-58rqc0cg	49	24	bacterial	bacterial	JJ
cord-016187-58rqc0cg	49	25	enzymes	enzyme	NNS
cord-016187-58rqc0cg	49	26	now	now	RB
cord-016187-58rqc0cg	49	27	even	even	RB
cord-016187-58rqc0cg	49	28	have	have	VBP
cord-016187-58rqc0cg	49	29	their	-PRON-	PRP$
cord-016187-58rqc0cg	49	30	own	own	JJ
cord-016187-58rqc0cg	49	31	internet	internet	NN
cord-016187-58rqc0cg	49	32	website	website	NN
cord-016187-58rqc0cg	49	33	devoted	devote	VBN
cord-016187-58rqc0cg	49	34	specifi	specifi	NN
cord-016187-58rqc0cg	49	35	cally	cally	RB
cord-016187-58rqc0cg	49	36	to	to	IN
cord-016187-58rqc0cg	49	37	their	-PRON-	PRP$
cord-016187-58rqc0cg	49	38	molecular	molecular	JJ
cord-016187-58rqc0cg	49	39	properties	property	NNS
cord-016187-58rqc0cg	49	40	(	(	-LRB-
cord-016187-58rqc0cg	49	41	http://	http://	NNP
cord-016187-58rqc0cg	49	42	www.lahey.org/studies/webt.htm	www.lahey.org/studies/webt.htm	NNP
cord-016187-58rqc0cg	49	43	)	)	-RRB-
cord-016187-58rqc0cg	49	44	.	.	.
cord-016187-58rqc0cg	50	1	Beta	beta	NN
cord-016187-58rqc0cg	50	2	-	-	HYPH
cord-016187-58rqc0cg	50	3	lactamase	lactamase	NN
cord-016187-58rqc0cg	50	4	activity	activity	NN
cord-016187-58rqc0cg	50	5	has	have	VBZ
cord-016187-58rqc0cg	50	6	become	become	VBN
cord-016187-58rqc0cg	50	7	so	so	RB
cord-016187-58rqc0cg	50	8	ubiquitous	ubiquitous	JJ
cord-016187-58rqc0cg	50	9	among	among	IN
cord-016187-58rqc0cg	50	10	bacterial	bacterial	JJ
cord-016187-58rqc0cg	50	11	populations	population	NNS
cord-016187-58rqc0cg	50	12	that	that	IN
cord-016187-58rqc0cg	50	13	it	-PRON-	PRP
cord-016187-58rqc0cg	50	14	has	have	VBZ
cord-016187-58rqc0cg	50	15	prompted	prompt	VBN
cord-016187-58rqc0cg	50	16	the	the	DT
cord-016187-58rqc0cg	50	17	development	development	NN
cord-016187-58rqc0cg	50	18	of	of	IN
cord-016187-58rqc0cg	50	19	specifi	specifi	NNP
cord-016187-58rqc0cg	50	20	c	c	NN
cord-016187-58rqc0cg	50	21	beta	beta	NN
cord-016187-58rqc0cg	50	22	-	-	HYPH
cord-016187-58rqc0cg	50	23	lactamase	lactamase	NN
cord-016187-58rqc0cg	50	24	inhibitor	inhibitor	NN
cord-016187-58rqc0cg	50	25	compounds	compound	NNS
cord-016187-58rqc0cg	50	26	(	(	-LRB-
cord-016187-58rqc0cg	50	27	clavulanate	clavulanate	NNP
cord-016187-58rqc0cg	50	28	,	,	,
cord-016187-58rqc0cg	50	29	tazobactam	tazobactam	NNP
cord-016187-58rqc0cg	50	30	and	and	CC
cord-016187-58rqc0cg	50	31	sulbactam	sulbactam	NNP
cord-016187-58rqc0cg	50	32	)	)	-RRB-
cord-016187-58rqc0cg	50	33	in	in	IN
cord-016187-58rqc0cg	50	34	an	an	DT
cord-016187-58rqc0cg	50	35	effort	effort	NN
cord-016187-58rqc0cg	50	36	to	to	TO
cord-016187-58rqc0cg	50	37	combat	combat	VB
cord-016187-58rqc0cg	50	38	this	this	DT
cord-016187-58rqc0cg	50	39	common	common	JJ
cord-016187-58rqc0cg	50	40	bacterial	bacterial	JJ
cord-016187-58rqc0cg	50	41	resistance	resistance	NN
cord-016187-58rqc0cg	50	42	mechanism	mechanism	NN
cord-016187-58rqc0cg	50	43	.	.	.
cord-016187-58rqc0cg	51	1	This	this	DT
cord-016187-58rqc0cg	51	2	has	have	VBZ
cord-016187-58rqc0cg	51	3	been	be	VBN
cord-016187-58rqc0cg	51	4	countered	counter	VBN
cord-016187-58rqc0cg	51	5	by	by	IN
cord-016187-58rqc0cg	51	6	the	the	DT
cord-016187-58rqc0cg	51	7	generation	generation	NN
cord-016187-58rqc0cg	51	8	of	of	IN
cord-016187-58rqc0cg	51	9	inhibitors	inhibitor	NNS
cord-016187-58rqc0cg	51	10	of	of	IN
cord-016187-58rqc0cg	51	11	these	these	DT
cord-016187-58rqc0cg	51	12	beta	beta	NN
cord-016187-58rqc0cg	51	13	-	-	HYPH
cord-016187-58rqc0cg	51	14	lactamase	lactamase	NN
cord-016187-58rqc0cg	51	15	inhibitors	inhibitor	NNS
cord-016187-58rqc0cg	51	16	by	by	IN
cord-016187-58rqc0cg	51	17	multidrug	multidrug	NN
cord-016187-58rqc0cg	51	18	-	-	HYPH
cord-016187-58rqc0cg	51	19	resistant	resistant	JJ
cord-016187-58rqc0cg	51	20	bacteria	bacteria	NNS
cord-016187-58rqc0cg	51	21	[	[	-LRB-
cord-016187-58rqc0cg	51	22	23	23	CD
cord-016187-58rqc0cg	51	23	]	]	-RRB-
cord-016187-58rqc0cg	51	24	in	in	IN
cord-016187-58rqc0cg	51	25	the	the	DT
cord-016187-58rqc0cg	51	26	ongoing	ongoing	JJ
cord-016187-58rqc0cg	51	27	confl	confl	NN
cord-016187-58rqc0cg	51	28	ict	ict	NN
cord-016187-58rqc0cg	51	29	between	between	IN
cord-016187-58rqc0cg	51	30	pathogens	pathogen	NNS
cord-016187-58rqc0cg	51	31	and	and	CC
cord-016187-58rqc0cg	51	32	chemotherapeutic	chemotherapeutic	JJ
cord-016187-58rqc0cg	51	33	strategies	strategy	NNS
cord-016187-58rqc0cg	51	34	to	to	TO
cord-016187-58rqc0cg	51	35	eradicate	eradicate	VB
cord-016187-58rqc0cg	51	36	these	these	DT
cord-016187-58rqc0cg	51	37	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	51	38	.	.	.
cord-016187-58rqc0cg	52	1	Recently	recently	RB
cord-016187-58rqc0cg	52	2	it	-PRON-	PRP
cord-016187-58rqc0cg	52	3	has	have	VBZ
cord-016187-58rqc0cg	52	4	been	be	VBN
cord-016187-58rqc0cg	52	5	demonstrated	demonstrate	VBN
cord-016187-58rqc0cg	52	6	that	that	IN
cord-016187-58rqc0cg	52	7	at	at	IN
cord-016187-58rqc0cg	52	8	least	least	JJS
cord-016187-58rqc0cg	52	9	some	some	DT
cord-016187-58rqc0cg	52	10	bacterial	bacterial	JJ
cord-016187-58rqc0cg	52	11	populations	population	NNS
cord-016187-58rqc0cg	52	12	have	have	VBP
cord-016187-58rqc0cg	52	13	the	the	DT
cord-016187-58rqc0cg	52	14	capacity	capacity	NN
cord-016187-58rqc0cg	52	15	to	to	TO
cord-016187-58rqc0cg	52	16	increase	increase	VB
cord-016187-58rqc0cg	52	17	their	-PRON-	PRP$
cord-016187-58rqc0cg	52	18	mutation	mutation	NN
cord-016187-58rqc0cg	52	19	rates	rate	NNS
cord-016187-58rqc0cg	52	20	during	during	IN
cord-016187-58rqc0cg	52	21	times	time	NNS
cord-016187-58rqc0cg	52	22	of	of	IN
cord-016187-58rqc0cg	52	23	environmental	environmental	JJ
cord-016187-58rqc0cg	52	24	stress	stress	NN
cord-016187-58rqc0cg	52	25	such	such	JJ
cord-016187-58rqc0cg	52	26	as	as	IN
cord-016187-58rqc0cg	52	27	exposure	exposure	NN
cord-016187-58rqc0cg	52	28	to	to	IN
cord-016187-58rqc0cg	52	29	an	an	DT
cord-016187-58rqc0cg	52	30	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	52	31	.	.	.
cord-016187-58rqc0cg	53	1	This	this	DT
cord-016187-58rqc0cg	53	2	stress	stress	NN
cord-016187-58rqc0cg	53	3	response	response	NN
cord-016187-58rqc0cg	53	4	is	be	VBZ
cord-016187-58rqc0cg	53	5	known	know	VBN
cord-016187-58rqc0cg	53	6	as	as	IN
cord-016187-58rqc0cg	53	7	the	the	DT
cord-016187-58rqc0cg	53	8	'	'	``
cord-016187-58rqc0cg	53	9	SOS	SOS	NNP
cord-016187-58rqc0cg	53	10	'	'	POS
cord-016187-58rqc0cg	53	11	response	response	NN
cord-016187-58rqc0cg	53	12	or	or	CC
cord-016187-58rqc0cg	53	13	transient	transient	JJ
cord-016187-58rqc0cg	53	14	hypermutation	hypermutation	NN
cord-016187-58rqc0cg	53	15	[	[	-LRB-
cord-016187-58rqc0cg	53	16	25	25	CD
cord-016187-58rqc0cg	53	17	]	]	-RRB-
cord-016187-58rqc0cg	53	18	.	.	.
cord-016187-58rqc0cg	54	1	It	-PRON-	PRP
cord-016187-58rqc0cg	54	2	is	be	VBZ
cord-016187-58rqc0cg	54	3	highly	highly	RB
cord-016187-58rqc0cg	54	4	advantageous	advantageous	JJ
cord-016187-58rqc0cg	54	5	for	for	IN
cord-016187-58rqc0cg	54	6	the	the	DT
cord-016187-58rqc0cg	54	7	organism	organism	NN
cord-016187-58rqc0cg	54	8	to	to	TO
cord-016187-58rqc0cg	54	9	increase	increase	VB
cord-016187-58rqc0cg	54	10	the	the	DT
cord-016187-58rqc0cg	54	11	rate	rate	NN
cord-016187-58rqc0cg	54	12	of	of	IN
cord-016187-58rqc0cg	54	13	genetic	genetic	JJ
cord-016187-58rqc0cg	54	14	variation	variation	NN
cord-016187-58rqc0cg	54	15	at	at	IN
cord-016187-58rqc0cg	54	16	times	time	NNS
cord-016187-58rqc0cg	54	17	of	of	IN
cord-016187-58rqc0cg	54	18	unfavorable	unfavorable	JJ
cord-016187-58rqc0cg	54	19	environmental	environmental	JJ
cord-016187-58rqc0cg	54	20	conditions	condition	NNS
cord-016187-58rqc0cg	54	21	.	.	.
cord-016187-58rqc0cg	55	1	It	-PRON-	PRP
cord-016187-58rqc0cg	55	2	is	be	VBZ
cord-016187-58rqc0cg	55	3	possible	possible	JJ
cord-016187-58rqc0cg	55	4	for	for	IN
cord-016187-58rqc0cg	55	5	bacteria	bacteria	NNS
cord-016187-58rqc0cg	55	6	to	to	TO
cord-016187-58rqc0cg	55	7	upregulate	upregulate	VB
cord-016187-58rqc0cg	55	8	the	the	DT
cord-016187-58rqc0cg	55	9	pace	pace	NN
cord-016187-58rqc0cg	55	10	of	of	IN
cord-016187-58rqc0cg	55	11	evolution	evolution	NN
cord-016187-58rqc0cg	55	12	in	in	IN
cord-016187-58rqc0cg	55	13	an	an	DT
cord-016187-58rqc0cg	55	14	attempt	attempt	NN
cord-016187-58rqc0cg	55	15	to	to	TO
cord-016187-58rqc0cg	55	16	develop	develop	VB
cord-016187-58rqc0cg	55	17	a	a	DT
cord-016187-58rqc0cg	55	18	clone	clone	NN
cord-016187-58rqc0cg	55	19	that	that	WDT
cord-016187-58rqc0cg	55	20	can	can	MD
cord-016187-58rqc0cg	55	21	resist	resist	VB
cord-016187-58rqc0cg	55	22	the	the	DT
cord-016187-58rqc0cg	55	23	action	action	NN
cord-016187-58rqc0cg	55	24	of	of	IN
cord-016187-58rqc0cg	55	25	an	an	DT
cord-016187-58rqc0cg	55	26	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	55	27	.	.	.
cord-016187-58rqc0cg	56	1	The	the	DT
cord-016187-58rqc0cg	56	2	DNA	dna	NN
cord-016187-58rqc0cg	56	3	polymerase	polymerase	NN
cord-016187-58rqc0cg	56	4	in	in	IN
cord-016187-58rqc0cg	56	5	such	such	JJ
cord-016187-58rqc0cg	56	6	organisms	organism	NNS
cord-016187-58rqc0cg	56	7	has	have	VBZ
cord-016187-58rqc0cg	56	8	reduced	reduce	VBN
cord-016187-58rqc0cg	56	9	fi	fi	NN
cord-016187-58rqc0cg	56	10	delity	delity	NN
cord-016187-58rqc0cg	56	11	of	of	IN
cord-016187-58rqc0cg	56	12	replication	replication	NN
cord-016187-58rqc0cg	56	13	and	and	CC
cord-016187-58rqc0cg	56	14	subsequently	subsequently	RB
cord-016187-58rqc0cg	56	15	an	an	DT
cord-016187-58rqc0cg	56	16	increased	increase	VBN
cord-016187-58rqc0cg	56	17	rate	rate	NN
cord-016187-58rqc0cg	56	18	in	in	IN
cord-016187-58rqc0cg	56	19	the	the	DT
cord-016187-58rqc0cg	56	20	mutational	mutational	JJ
cord-016187-58rqc0cg	56	21	occurrences	occurrence	NNS
cord-016187-58rqc0cg	56	22	as	as	IN
cord-016187-58rqc0cg	56	23	a	a	DT
cord-016187-58rqc0cg	56	24	result	result	NN
cord-016187-58rqc0cg	56	25	of	of	IN
cord-016187-58rqc0cg	56	26	excess	excess	JJ
cord-016187-58rqc0cg	56	27	nucleotide	nucleotide	JJ
cord-016187-58rqc0cg	56	28	mispairing	mispairing	NN
cord-016187-58rqc0cg	56	29	.	.	.
cord-016187-58rqc0cg	57	1	The	the	DT
cord-016187-58rqc0cg	57	2	recombination	recombination	NN
cord-016187-58rqc0cg	57	3	system	system	NN
cord-016187-58rqc0cg	57	4	of	of	IN
cord-016187-58rqc0cg	57	5	bacteria	bacteria	NNS
cord-016187-58rqc0cg	57	6	(	(	-LRB-
cord-016187-58rqc0cg	57	7	the	the	DT
cord-016187-58rqc0cg	57	8	recA	recA	NNP
cord-016187-58rqc0cg	57	9	system	system	NN
cord-016187-58rqc0cg	57	10	)	)	-RRB-
cord-016187-58rqc0cg	57	11	becomes	become	VBZ
cord-016187-58rqc0cg	57	12	less	less	RBR
cord-016187-58rqc0cg	57	13	restrictive	restrictive	JJ
cord-016187-58rqc0cg	57	14	in	in	IN
cord-016187-58rqc0cg	57	15	the	the	DT
cord-016187-58rqc0cg	57	16	degree	degree	NN
cord-016187-58rqc0cg	57	17	homology	homology	NN
cord-016187-58rqc0cg	57	18	between	between	IN
cord-016187-58rqc0cg	57	19	DNA	dna	NN
cord-016187-58rqc0cg	57	20	sequences	sequence	NNS
cord-016187-58rqc0cg	57	21	before	before	IN
cord-016187-58rqc0cg	57	22	a	a	DT
cord-016187-58rqc0cg	57	23	crossover	crossover	NN
cord-016187-58rqc0cg	57	24	event	event	NN
cord-016187-58rqc0cg	57	25	is	be	VBZ
cord-016187-58rqc0cg	57	26	permitted	permit	VBN
cord-016187-58rqc0cg	57	27	to	to	TO
cord-016187-58rqc0cg	57	28	occur	occur	VB
cord-016187-58rqc0cg	57	29	.	.	.
cord-016187-58rqc0cg	58	1	A	a	DT
cord-016187-58rqc0cg	58	2	fl	fl	NNP
cord-016187-58rqc0cg	58	3	urry	urry	NN
cord-016187-58rqc0cg	58	4	of	of	IN
cord-016187-58rqc0cg	58	5	mutational	mutational	JJ
cord-016187-58rqc0cg	58	6	events	event	NNS
cord-016187-58rqc0cg	58	7	occur	occur	VBP
cord-016187-58rqc0cg	58	8	in	in	IN
cord-016187-58rqc0cg	58	9	stressed	stress	VBN
cord-016187-58rqc0cg	58	10	bacteria	bacteria	NNS
cord-016187-58rqc0cg	58	11	in	in	IN
cord-016187-58rqc0cg	58	12	a	a	DT
cord-016187-58rqc0cg	58	13	fi	fi	NN
cord-016187-58rqc0cg	58	14	nal	nal	FW
cord-016187-58rqc0cg	58	15	attempt	attempt	NN
cord-016187-58rqc0cg	58	16	to	to	TO
cord-016187-58rqc0cg	58	17	generate	generate	VB
cord-016187-58rqc0cg	58	18	a	a	DT
cord-016187-58rqc0cg	58	19	resistant	resistant	JJ
cord-016187-58rqc0cg	58	20	subpopulation	subpopulation	NN
cord-016187-58rqc0cg	58	21	of	of	IN
cord-016187-58rqc0cg	58	22	bacteria	bacteria	NNS
cord-016187-58rqc0cg	58	23	in	in	IN
cord-016187-58rqc0cg	58	24	the	the	DT
cord-016187-58rqc0cg	58	25	presence	presence	NN
cord-016187-58rqc0cg	58	26	of	of	IN
cord-016187-58rqc0cg	58	27	an	an	DT
cord-016187-58rqc0cg	58	28	environmental	environmental	JJ
cord-016187-58rqc0cg	58	29	challenge	challenge	NN
cord-016187-58rqc0cg	58	30	such	such	JJ
cord-016187-58rqc0cg	58	31	as	as	IN
cord-016187-58rqc0cg	58	32	the	the	DT
cord-016187-58rqc0cg	58	33	presence	presence	NN
cord-016187-58rqc0cg	58	34	of	of	IN
cord-016187-58rqc0cg	58	35	a	a	DT
cord-016187-58rqc0cg	58	36	new	new	JJ
cord-016187-58rqc0cg	58	37	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	58	38	.	.	.
cord-016187-58rqc0cg	59	1	This	this	DT
cord-016187-58rqc0cg	59	2	process	process	NN
cord-016187-58rqc0cg	59	3	has	have	VBZ
cord-016187-58rqc0cg	59	4	even	even	RB
cord-016187-58rqc0cg	59	5	been	be	VBN
cord-016187-58rqc0cg	59	6	phenotypically	phenotypically	RB
cord-016187-58rqc0cg	59	7	linked	link	VBN
cord-016187-58rqc0cg	59	8	with	with	IN
cord-016187-58rqc0cg	59	9	alterations	alteration	NNS
cord-016187-58rqc0cg	59	10	in	in	IN
cord-016187-58rqc0cg	59	11	growth	growth	NN
cord-016187-58rqc0cg	59	12	rate	rate	NN
cord-016187-58rqc0cg	59	13	and	and	CC
cord-016187-58rqc0cg	59	14	biofi	biofi	NNP
cord-016187-58rqc0cg	59	15	lm	lm	NNP
cord-016187-58rqc0cg	59	16	formation	formation	NN
cord-016187-58rqc0cg	59	17	in	in	IN
cord-016187-58rqc0cg	59	18	some	some	DT
cord-016187-58rqc0cg	59	19	strains	strain	NNS
cord-016187-58rqc0cg	59	20	of	of	IN
cord-016187-58rqc0cg	59	21	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	59	22	aeruginosa	aeruginosa	VBZ
cord-016187-58rqc0cg	59	23	[	[	-LRB-
cord-016187-58rqc0cg	59	24	26	26	CD
cord-016187-58rqc0cg	59	25	]	]	-RRB-
cord-016187-58rqc0cg	59	26	.	.	.
cord-016187-58rqc0cg	60	1	A	a	DT
cord-016187-58rqc0cg	60	2	second	second	JJ
cord-016187-58rqc0cg	60	3	level	level	NN
cord-016187-58rqc0cg	60	4	of	of	IN
cord-016187-58rqc0cg	60	5	genomic	genomic	JJ
cord-016187-58rqc0cg	60	6	variability	variability	NN
cord-016187-58rqc0cg	60	7	in	in	IN
cord-016187-58rqc0cg	60	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	60	9	is	be	VBZ
cord-016187-58rqc0cg	60	10	referred	refer	VBN
cord-016187-58rqc0cg	60	11	to	to	IN
cord-016187-58rqc0cg	60	12	as	as	IN
cord-016187-58rqc0cg	60	13	a	a	DT
cord-016187-58rqc0cg	60	14	macro	macro	JJ
cord-016187-58rqc0cg	60	15	-	-	HYPH
cord-016187-58rqc0cg	60	16	evolutionary	evolutionary	JJ
cord-016187-58rqc0cg	60	17	change	change	NN
cord-016187-58rqc0cg	60	18	and	and	CC
cord-016187-58rqc0cg	60	19	results	result	NNS
cord-016187-58rqc0cg	60	20	in	in	IN
cord-016187-58rqc0cg	60	21	whole	whole	JJ
cord-016187-58rqc0cg	60	22	-	-	HYPH
cord-016187-58rqc0cg	60	23	scale	scale	NN
cord-016187-58rqc0cg	60	24	rearrangements	rearrangement	NNS
cord-016187-58rqc0cg	60	25	of	of	IN
cord-016187-58rqc0cg	60	26	large	large	JJ
cord-016187-58rqc0cg	60	27	segments	segment	NNS
cord-016187-58rqc0cg	60	28	of	of	IN
cord-016187-58rqc0cg	60	29	DNA	DNA	NNP
cord-016187-58rqc0cg	60	30	as	as	IN
cord-016187-58rqc0cg	60	31	a	a	DT
cord-016187-58rqc0cg	60	32	single	single	JJ
cord-016187-58rqc0cg	60	33	event	event	NN
cord-016187-58rqc0cg	60	34	.	.	.
cord-016187-58rqc0cg	61	1	Such	such	JJ
cord-016187-58rqc0cg	61	2	rearrangements	rearrangement	NNS
cord-016187-58rqc0cg	61	3	may	may	MD
cord-016187-58rqc0cg	61	4	include	include	VB
cord-016187-58rqc0cg	61	5	inversions	inversion	NNS
cord-016187-58rqc0cg	61	6	,	,	,
cord-016187-58rqc0cg	61	7	duplica-	duplica-	JJ
cord-016187-58rqc0cg	61	8	tions	tion	NNS
cord-016187-58rqc0cg	61	9	,	,	,
cord-016187-58rqc0cg	61	10	insertions	insertion	NNS
cord-016187-58rqc0cg	61	11	,	,	,
cord-016187-58rqc0cg	61	12	deletions	deletion	NNS
cord-016187-58rqc0cg	61	13	,	,	,
cord-016187-58rqc0cg	61	14	or	or	CC
cord-016187-58rqc0cg	61	15	transposition	transposition	NN
cord-016187-58rqc0cg	61	16	of	of	IN
cord-016187-58rqc0cg	61	17	large	large	JJ
cord-016187-58rqc0cg	61	18	sequences	sequence	NNS
cord-016187-58rqc0cg	61	19	of	of	IN
cord-016187-58rqc0cg	61	20	DNA	DNA	NNP
cord-016187-58rqc0cg	61	21	from	from	IN
cord-016187-58rqc0cg	61	22	one	one	CD
cord-016187-58rqc0cg	61	23	location	location	NN
cord-016187-58rqc0cg	61	24	of	of	IN
cord-016187-58rqc0cg	61	25	a	a	DT
cord-016187-58rqc0cg	61	26	bacterial	bacterial	JJ
cord-016187-58rqc0cg	61	27	chromosome	chromosome	NN
cord-016187-58rqc0cg	61	28	or	or	CC
cord-016187-58rqc0cg	61	29	plasmid	plasmid	NN
cord-016187-58rqc0cg	61	30	to	to	IN
cord-016187-58rqc0cg	61	31	another	another	DT
cord-016187-58rqc0cg	61	32	.	.	.
cord-016187-58rqc0cg	62	1	These	these	DT
cord-016187-58rqc0cg	62	2	whole	whole	JJ
cord-016187-58rqc0cg	62	3	-	-	HYPH
cord-016187-58rqc0cg	62	4	scale	scale	NN
cord-016187-58rqc0cg	62	5	rearrangements	rearrangement	NNS
cord-016187-58rqc0cg	62	6	of	of	IN
cord-016187-58rqc0cg	62	7	large	large	JJ
cord-016187-58rqc0cg	62	8	segments	segment	NNS
cord-016187-58rqc0cg	62	9	of	of	IN
cord-016187-58rqc0cg	62	10	the	the	DT
cord-016187-58rqc0cg	62	11	bacterial	bacterial	JJ
cord-016187-58rqc0cg	62	12	genome	genome	NN
cord-016187-58rqc0cg	62	13	are	be	VBP
cord-016187-58rqc0cg	62	14	frequently	frequently	RB
cord-016187-58rqc0cg	62	15	created	create	VBN
cord-016187-58rqc0cg	62	16	by	by	IN
cord-016187-58rqc0cg	62	17	specialized	specialized	JJ
cord-016187-58rqc0cg	62	18	genetic	genetic	JJ
cord-016187-58rqc0cg	62	19	elements	element	NNS
cord-016187-58rqc0cg	62	20	known	know	VBN
cord-016187-58rqc0cg	62	21	as	as	IN
cord-016187-58rqc0cg	62	22	transposons	transposon	NNS
cord-016187-58rqc0cg	62	23	or	or	CC
cord-016187-58rqc0cg	62	24	insertion	insertion	NN
cord-016187-58rqc0cg	62	25	sequences	sequence	NNS
cord-016187-58rqc0cg	62	26	,	,	,
cord-016187-58rqc0cg	62	27	which	which	WDT
cord-016187-58rqc0cg	62	28	have	have	VBP
cord-016187-58rqc0cg	62	29	the	the	DT
cord-016187-58rqc0cg	62	30	capacity	capacity	NN
cord-016187-58rqc0cg	62	31	to	to	TO
cord-016187-58rqc0cg	62	32	move	move	VB
cord-016187-58rqc0cg	62	33	independently	independently	RB
cord-016187-58rqc0cg	62	34	as	as	IN
cord-016187-58rqc0cg	62	35	a	a	DT
cord-016187-58rqc0cg	62	36	unit	unit	NN
cord-016187-58rqc0cg	62	37	from	from	IN
cord-016187-58rqc0cg	62	38	the	the	DT
cord-016187-58rqc0cg	62	39	rest	rest	NN
cord-016187-58rqc0cg	62	40	of	of	IN
cord-016187-58rqc0cg	62	41	the	the	DT
cord-016187-58rqc0cg	62	42	bacterial	bacterial	JJ
cord-016187-58rqc0cg	62	43	genome	genome	NN
cord-016187-58rqc0cg	62	44	[	[	-LRB-
cord-016187-58rqc0cg	62	45	23	23	CD
cord-016187-58rqc0cg	62	46	]	]	-RRB-
cord-016187-58rqc0cg	62	47	.	.	.
cord-016187-58rqc0cg	63	1	Acquisition	acquisition	NN
cord-016187-58rqc0cg	63	2	of	of	IN
cord-016187-58rqc0cg	63	3	foreign	foreign	JJ
cord-016187-58rqc0cg	63	4	DNA	dna	NN
cord-016187-58rqc0cg	63	5	sequences	sequence	NNS
cord-016187-58rqc0cg	63	6	from	from	IN
cord-016187-58rqc0cg	63	7	the	the	DT
cord-016187-58rqc0cg	63	8	extracellular	extracellular	JJ
cord-016187-58rqc0cg	63	9	environment	environment	NN
cord-016187-58rqc0cg	63	10	may	may	MD
cord-016187-58rqc0cg	63	11	be	be	VB
cord-016187-58rqc0cg	63	12	taken	take	VBN
cord-016187-58rqc0cg	63	13	up	up	RP
cord-016187-58rqc0cg	63	14	by	by	IN
cord-016187-58rqc0cg	63	15	naturally	naturally	RB
cord-016187-58rqc0cg	63	16	competent	competent	JJ
cord-016187-58rqc0cg	63	17	bacteria	bacteria	NNS
cord-016187-58rqc0cg	63	18	(	(	-LRB-
cord-016187-58rqc0cg	63	19	e.g.	e.g.	RB
cord-016187-58rqc0cg	63	20	,	,	,
cord-016187-58rqc0cg	63	21	some	some	DT
cord-016187-58rqc0cg	63	22	streptococci	streptococcus	NNS
cord-016187-58rqc0cg	63	23	and	and	CC
cord-016187-58rqc0cg	63	24	neisserial	neisserial	JJ
cord-016187-58rqc0cg	63	25	organisms	organism	NNS
cord-016187-58rqc0cg	63	26	)	)	-RRB-
cord-016187-58rqc0cg	63	27	by	by	IN
cord-016187-58rqc0cg	63	28	transformation	transformation	NN
cord-016187-58rqc0cg	63	29	.	.	.
cord-016187-58rqc0cg	64	1	These	these	DT
cord-016187-58rqc0cg	64	2	sequences	sequence	NNS
cord-016187-58rqc0cg	64	3	can	can	MD
cord-016187-58rqc0cg	64	4	then	then	RB
cord-016187-58rqc0cg	64	5	become	become	VB
cord-016187-58rqc0cg	64	6	integrated	integrate	VBN
cord-016187-58rqc0cg	64	7	into	into	IN
cord-016187-58rqc0cg	64	8	the	the	DT
cord-016187-58rqc0cg	64	9	host	host	NN
cord-016187-58rqc0cg	64	10	genome	genome	NN
cord-016187-58rqc0cg	64	11	into	into	IN
cord-016187-58rqc0cg	64	12	homologous	homologous	JJ
cord-016187-58rqc0cg	64	13	sequences	sequence	NNS
cord-016187-58rqc0cg	64	14	by	by	IN
cord-016187-58rqc0cg	64	15	the	the	DT
cord-016187-58rqc0cg	64	16	generalized	generalized	JJ
cord-016187-58rqc0cg	64	17	recombination	recombination	NN
cord-016187-58rqc0cg	64	18	and	and	CC
cord-016187-58rqc0cg	64	19	DNA	dna	NN
cord-016187-58rqc0cg	64	20	repair	repair	NN
cord-016187-58rqc0cg	64	21	system	system	NN
cord-016187-58rqc0cg	64	22	bacteria	bacteria	NNS
cord-016187-58rqc0cg	64	23	.	.	.
cord-016187-58rqc0cg	65	1	Inheritance	inheritance	NN
cord-016187-58rqc0cg	65	2	of	of	IN
cord-016187-58rqc0cg	65	3	these	these	DT
cord-016187-58rqc0cg	65	4	foreign	foreign	JJ
cord-016187-58rqc0cg	65	5	DNA	dna	NN
cord-016187-58rqc0cg	65	6	elements	element	NNS
cord-016187-58rqc0cg	65	7	further	further	RB
cord-016187-58rqc0cg	65	8	contributes	contribute	VBZ
cord-016187-58rqc0cg	65	9	to	to	IN
cord-016187-58rqc0cg	65	10	the	the	DT
cord-016187-58rqc0cg	65	11	organism	organism	NN
cord-016187-58rqc0cg	65	12	's	's	POS
cord-016187-58rqc0cg	65	13	ability	ability	NN
cord-016187-58rqc0cg	65	14	to	to	TO
cord-016187-58rqc0cg	65	15	cope	cope	VB
cord-016187-58rqc0cg	65	16	with	with	IN
cord-016187-58rqc0cg	65	17	selection	selection	NN
cord-016187-58rqc0cg	65	18	pressures	pressure	NNS
cord-016187-58rqc0cg	65	19	imposed	impose	VBN
cord-016187-58rqc0cg	65	20	upon	upon	IN
cord-016187-58rqc0cg	65	21	them	-PRON-	PRP
cord-016187-58rqc0cg	65	22	by	by	IN
cord-016187-58rqc0cg	65	23	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	65	24	agents	agent	NNS
cord-016187-58rqc0cg	65	25	[	[	-LRB-
cord-016187-58rqc0cg	65	26	23	23	CD
cord-016187-58rqc0cg	65	27	]	]	-RRB-
cord-016187-58rqc0cg	65	28	.	.	.
cord-016187-58rqc0cg	66	1	A	a	DT
cord-016187-58rqc0cg	66	2	third	third	JJ
cord-016187-58rqc0cg	66	3	level	level	NN
cord-016187-58rqc0cg	66	4	of	of	IN
cord-016187-58rqc0cg	66	5	genetic	genetic	JJ
cord-016187-58rqc0cg	66	6	variability	variability	NN
cord-016187-58rqc0cg	66	7	in	in	IN
cord-016187-58rqc0cg	66	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	66	9	is	be	VBZ
cord-016187-58rqc0cg	66	10	created	create	VBN
cord-016187-58rqc0cg	66	11	by	by	IN
cord-016187-58rqc0cg	66	12	the	the	DT
cord-016187-58rqc0cg	66	13	acquisition	acquisition	NN
cord-016187-58rqc0cg	66	14	of	of	IN
cord-016187-58rqc0cg	66	15	foreign	foreign	JJ
cord-016187-58rqc0cg	66	16	DNA	dna	NN
cord-016187-58rqc0cg	66	17	carried	carry	VBN
cord-016187-58rqc0cg	66	18	by	by	IN
cord-016187-58rqc0cg	66	19	plasmids	plasmid	NNS
cord-016187-58rqc0cg	66	20	and	and	CC
cord-016187-58rqc0cg	66	21	bacteriophages	bacteriophage	NNS
cord-016187-58rqc0cg	66	22	.	.	.
cord-016187-58rqc0cg	67	1	These	these	DT
cord-016187-58rqc0cg	67	2	extrachromosomal	extrachromosomal	VBN
cord-016187-58rqc0cg	67	3	DNA	dna	NN
cord-016187-58rqc0cg	67	4	elements	element	NNS
cord-016187-58rqc0cg	67	5	provide	provide	VBP
cord-016187-58rqc0cg	67	6	ready	ready	JJ
cord-016187-58rqc0cg	67	7	access	access	NN
cord-016187-58rqc0cg	67	8	to	to	IN
cord-016187-58rqc0cg	67	9	disposable	disposable	JJ
cord-016187-58rqc0cg	67	10	yet	yet	CC
cord-016187-58rqc0cg	67	11	potentially	potentially	RB
cord-016187-58rqc0cg	67	12	highly	highly	RB
cord-016187-58rqc0cg	67	13	advantageous	advantageous	JJ
cord-016187-58rqc0cg	67	14	genes	gene	NNS
cord-016187-58rqc0cg	67	15	including	include	VBG
cord-016187-58rqc0cg	67	16	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	67	17	resistance	resistance	NN
cord-016187-58rqc0cg	67	18	genes	gene	NNS
cord-016187-58rqc0cg	67	19	from	from	IN
cord-016187-58rqc0cg	67	20	plasmids	plasmid	NNS
cord-016187-58rqc0cg	67	21	or	or	CC
cord-016187-58rqc0cg	67	22	phage	phage	NN
cord-016187-58rqc0cg	67	23	particles	particle	NNS
cord-016187-58rqc0cg	67	24	.	.	.
cord-016187-58rqc0cg	68	1	These	these	DT
cord-016187-58rqc0cg	68	2	elements	element	NNS
cord-016187-58rqc0cg	68	3	are	be	VBP
cord-016187-58rqc0cg	68	4	autonomously	autonomously	RB
cord-016187-58rqc0cg	68	5	self	self	NN
cord-016187-58rqc0cg	68	6	-	-	HYPH
cord-016187-58rqc0cg	68	7	replicating	replicate	VBG
cord-016187-58rqc0cg	68	8	,	,	,
cord-016187-58rqc0cg	68	9	and	and	CC
cord-016187-58rqc0cg	68	10	they	-PRON-	PRP
cord-016187-58rqc0cg	68	11	can	can	MD
cord-016187-58rqc0cg	68	12	remain	remain	VB
cord-016187-58rqc0cg	68	13	unattached	unattached	JJ
cord-016187-58rqc0cg	68	14	in	in	IN
cord-016187-58rqc0cg	68	15	the	the	DT
cord-016187-58rqc0cg	68	16	cytoplasm	cytoplasm	NN
cord-016187-58rqc0cg	68	17	of	of	IN
cord-016187-58rqc0cg	68	18	bacterial	bacterial	JJ
cord-016187-58rqc0cg	68	19	cells	cell	NNS
cord-016187-58rqc0cg	68	20	or	or	CC
cord-016187-58rqc0cg	68	21	integrate	integrate	VBP
cord-016187-58rqc0cg	68	22	directly	directly	RB
cord-016187-58rqc0cg	68	23	into	into	IN
cord-016187-58rqc0cg	68	24	the	the	DT
cord-016187-58rqc0cg	68	25	chromosome	chromosome	NN
cord-016187-58rqc0cg	68	26	of	of	IN
cord-016187-58rqc0cg	68	27	the	the	DT
cord-016187-58rqc0cg	68	28	bacterial	bacterial	JJ
cord-016187-58rqc0cg	68	29	host	host	NN
cord-016187-58rqc0cg	68	30	.	.	.
cord-016187-58rqc0cg	69	1	They	-PRON-	PRP
cord-016187-58rqc0cg	69	2	have	have	VBP
cord-016187-58rqc0cg	69	3	the	the	DT
cord-016187-58rqc0cg	69	4	capacity	capacity	NN
cord-016187-58rqc0cg	69	5	to	to	TO
cord-016187-58rqc0cg	69	6	replicate	replicate	VB
cord-016187-58rqc0cg	69	7	and	and	CC
cord-016187-58rqc0cg	69	8	move	move	VB
cord-016187-58rqc0cg	69	9	independently	independently	RB
cord-016187-58rqc0cg	69	10	from	from	IN
cord-016187-58rqc0cg	69	11	the	the	DT
cord-016187-58rqc0cg	69	12	chromosome	chromosome	NN
cord-016187-58rqc0cg	69	13	adding	add	VBG
cord-016187-58rqc0cg	69	14	further	further	JJ
cord-016187-58rqc0cg	69	15	variability	variability	NN
cord-016187-58rqc0cg	69	16	to	to	IN
cord-016187-58rqc0cg	69	17	the	the	DT
cord-016187-58rqc0cg	69	18	entire	entire	JJ
cord-016187-58rqc0cg	69	19	bacterial	bacterial	JJ
cord-016187-58rqc0cg	69	20	genomic	genomic	JJ
cord-016187-58rqc0cg	69	21	DNA	dna	NN
cord-016187-58rqc0cg	69	22	.	.	.
cord-016187-58rqc0cg	70	1	Evidence	evidence	NN
cord-016187-58rqc0cg	70	2	from	from	IN
cord-016187-58rqc0cg	70	3	whole	whole	JJ
cord-016187-58rqc0cg	70	4	genome	genome	NN
cord-016187-58rqc0cg	70	5	sequencing	sequencing	NN
cord-016187-58rqc0cg	70	6	projects	project	NNS
cord-016187-58rqc0cg	70	7	indicates	indicate	VBZ
cord-016187-58rqc0cg	70	8	that	that	IN
cord-016187-58rqc0cg	70	9	these	these	DT
cord-016187-58rqc0cg	70	10	genomic	genomic	JJ
cord-016187-58rqc0cg	70	11	rearrangements	rearrangement	NNS
cord-016187-58rqc0cg	70	12	,	,	,
cord-016187-58rqc0cg	70	13	bacteriophage	bacteriophage	NN
cord-016187-58rqc0cg	70	14	sequences	sequence	NNS
cord-016187-58rqc0cg	70	15	and	and	CC
cord-016187-58rqc0cg	70	16	insertion	insertion	NN
cord-016187-58rqc0cg	70	17	sequences	sequence	NNS
cord-016187-58rqc0cg	70	18	are	be	VBP
cord-016187-58rqc0cg	70	19	commonplace	commonplace	JJ
cord-016187-58rqc0cg	70	20	in	in	IN
cord-016187-58rqc0cg	70	21	bacterial	bacterial	JJ
cord-016187-58rqc0cg	70	22	chromosomes	chromosome	NNS
cord-016187-58rqc0cg	70	23	[	[	-LRB-
cord-016187-58rqc0cg	70	24	27	27	CD
cord-016187-58rqc0cg	70	25	]	]	-RRB-
cord-016187-58rqc0cg	70	26	.	.	.
cord-016187-58rqc0cg	71	1	These	these	DT
cord-016187-58rqc0cg	71	2	genetic	genetic	JJ
cord-016187-58rqc0cg	71	3	variations	variation	NNS
cord-016187-58rqc0cg	71	4	provide	provide	VBP
cord-016187-58rqc0cg	71	5	bacteria	bacteria	NNS
cord-016187-58rqc0cg	71	6	with	with	IN
cord-016187-58rqc0cg	71	7	the	the	DT
cord-016187-58rqc0cg	71	8	seemingly	seemingly	RB
cord-016187-58rqc0cg	71	9	limitless	limitless	JJ
cord-016187-58rqc0cg	71	10	system	system	NN
cord-016187-58rqc0cg	71	11	to	to	TO
cord-016187-58rqc0cg	71	12	alter	alter	VB
cord-016187-58rqc0cg	71	13	their	-PRON-	PRP$
cord-016187-58rqc0cg	71	14	genomes	genome	NNS
cord-016187-58rqc0cg	71	15	,	,	,
cord-016187-58rqc0cg	71	16	rapidly	rapidly	RB
cord-016187-58rqc0cg	71	17	evolve	evolve	VB
cord-016187-58rqc0cg	71	18	and	and	CC
cord-016187-58rqc0cg	71	19	develop	develop	VB
cord-016187-58rqc0cg	71	20	resistance	resistance	NN
cord-016187-58rqc0cg	71	21	to	to	IN
cord-016187-58rqc0cg	71	22	virtually	virtually	RB
cord-016187-58rqc0cg	71	23	any	any	DT
cord-016187-58rqc0cg	71	24	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	71	25	agent	agent	NN
cord-016187-58rqc0cg	71	26	.	.	.
cord-016187-58rqc0cg	72	1	Recent	recent	JJ
cord-016187-58rqc0cg	72	2	examples	example	NNS
cord-016187-58rqc0cg	72	3	of	of	IN
cord-016187-58rqc0cg	72	4	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	72	5	-	-	HYPH
cord-016187-58rqc0cg	72	6	resistance	resistance	NN
cord-016187-58rqc0cg	72	7	in	in	IN
cord-016187-58rqc0cg	72	8	enterococci	enterococci	NNP
cord-016187-58rqc0cg	72	9	[	[	-LRB-
cord-016187-58rqc0cg	72	10	23	23	CD
cord-016187-58rqc0cg	72	11	]	]	-RRB-
cord-016187-58rqc0cg	73	1	,	,	,
cord-016187-58rqc0cg	73	2	S.	S.	NNP
cord-016187-58rqc0cg	73	3	aureus	aureus	NN
cord-016187-58rqc0cg	73	4	[	[	-LRB-
cord-016187-58rqc0cg	73	5	27	27	CD
cord-016187-58rqc0cg	73	6	]	]	-RRB-
cord-016187-58rqc0cg	73	7	,	,	,
cord-016187-58rqc0cg	73	8	and	and	CC
cord-016187-58rqc0cg	73	9	extended	extended	JJ
cord-016187-58rqc0cg	73	10	spectrum	spectrum	NN
cord-016187-58rqc0cg	73	11	beta	beta	NN
cord-016187-58rqc0cg	73	12	-	-	HYPH
cord-016187-58rqc0cg	73	13	lactamases	lactamase	NNS
cord-016187-58rqc0cg	73	14	[	[	-LRB-
cord-016187-58rqc0cg	73	15	23	23	CD
cord-016187-58rqc0cg	73	16	]	]	-RRB-
cord-016187-58rqc0cg	73	17	,	,	,
cord-016187-58rqc0cg	73	18	carbapenemase	carbapenemase	NN
cord-016187-58rqc0cg	73	19	production	production	NN
cord-016187-58rqc0cg	73	20	[	[	-LRB-
cord-016187-58rqc0cg	73	21	28	28	CD
cord-016187-58rqc0cg	73	22	]	]	-RRB-
cord-016187-58rqc0cg	73	23	and	and	CC
cord-016187-58rqc0cg	73	24	transferable	transferable	JJ
cord-016187-58rqc0cg	73	25	quinolone	quinolone	NNP
cord-016187-58rqc0cg	73	26	resistance	resistance	NN
cord-016187-58rqc0cg	73	27	in	in	IN
cord-016187-58rqc0cg	73	28	P.	P.	NNP
cord-016187-58rqc0cg	73	29	aeruginosa	aeruginosa	NNP
cord-016187-58rqc0cg	73	30	and	and	CC
cord-016187-58rqc0cg	73	31	enterobacteria	enterobacteria	NNP
cord-016187-58rqc0cg	73	32	[	[	-LRB-
cord-016187-58rqc0cg	73	33	23	23	CD
cord-016187-58rqc0cg	73	34	]	]	-RRB-
cord-016187-58rqc0cg	73	35	attest	attest	VBP
cord-016187-58rqc0cg	73	36	to	to	IN
cord-016187-58rqc0cg	73	37	the	the	DT
cord-016187-58rqc0cg	73	38	capacity	capacity	NN
cord-016187-58rqc0cg	73	39	of	of	IN
cord-016187-58rqc0cg	73	40	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	73	41	to	to	TO
cord-016187-58rqc0cg	73	42	adapt	adapt	VB
cord-016187-58rqc0cg	73	43	to	to	IN
cord-016187-58rqc0cg	73	44	environmental	environmental	JJ
cord-016187-58rqc0cg	73	45	stresses	stress	NNS
cord-016187-58rqc0cg	73	46	induced	induce	VBN
cord-016187-58rqc0cg	73	47	by	by	IN
cord-016187-58rqc0cg	73	48	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	73	49	exposure	exposure	NN
cord-016187-58rqc0cg	73	50	.	.	.
cord-016187-58rqc0cg	74	1	Viruses	virus	NNS
cord-016187-58rqc0cg	74	2	[	[	-LRB-
cord-016187-58rqc0cg	74	3	19	19	CD
cord-016187-58rqc0cg	74	4	]	]	-RRB-
cord-016187-58rqc0cg	74	5	and	and	CC
cord-016187-58rqc0cg	74	6	fungi	fungus	NNS
cord-016187-58rqc0cg	74	7	[	[	-LRB-
cord-016187-58rqc0cg	74	8	20	20	CD
cord-016187-58rqc0cg	74	9	]	]	-RRB-
cord-016187-58rqc0cg	74	10	are	be	VBP
cord-016187-58rqc0cg	74	11	also	also	RB
cord-016187-58rqc0cg	74	12	quite	quite	RB
cord-016187-58rqc0cg	74	13	capable	capable	JJ
cord-016187-58rqc0cg	74	14	of	of	IN
cord-016187-58rqc0cg	74	15	rapid	rapid	JJ
cord-016187-58rqc0cg	74	16	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	74	17	resistance	resistance	NN
cord-016187-58rqc0cg	74	18	development	development	NN
cord-016187-58rqc0cg	74	19	and	and	CC
cord-016187-58rqc0cg	75	1	these	these	DT
cord-016187-58rqc0cg	75	2	resistance	resistance	NN
cord-016187-58rqc0cg	75	3	capacities	capacity	NNS
cord-016187-58rqc0cg	75	4	pose	pose	VBP
cord-016187-58rqc0cg	75	5	additional	additional	JJ
cord-016187-58rqc0cg	75	6	threats	threat	NNS
cord-016187-58rqc0cg	75	7	in	in	IN
cord-016187-58rqc0cg	75	8	the	the	DT
cord-016187-58rqc0cg	75	9	management	management	NN
cord-016187-58rqc0cg	75	10	of	of	IN
cord-016187-58rqc0cg	75	11	ICU	ICU	NNP
cord-016187-58rqc0cg	75	12	patients	patient	NNS
cord-016187-58rqc0cg	75	13	with	with	IN
cord-016187-58rqc0cg	75	14	serious	serious	JJ
cord-016187-58rqc0cg	75	15	infections	infection	NNS
cord-016187-58rqc0cg	75	16	from	from	IN
cord-016187-58rqc0cg	75	17	a	a	DT
cord-016187-58rqc0cg	75	18	variety	variety	NN
cord-016187-58rqc0cg	75	19	of	of	IN
cord-016187-58rqc0cg	75	20	potential	potential	JJ
cord-016187-58rqc0cg	75	21	pathogens	pathogen	NNS
cord-016187-58rqc0cg	75	22	[	[	-LRB-
cord-016187-58rqc0cg	75	23	29	29	CD
cord-016187-58rqc0cg	75	24	]	]	-RRB-
cord-016187-58rqc0cg	75	25	.	.	.
cord-016187-58rqc0cg	76	1	Antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	76	2	resistance	resistance	NN
cord-016187-58rqc0cg	76	3	genes	gene	NNS
cord-016187-58rqc0cg	76	4	probably	probably	RB
cord-016187-58rqc0cg	76	5	arose	arise	VBD
cord-016187-58rqc0cg	76	6	from	from	IN
cord-016187-58rqc0cg	76	7	detoxifying	detoxify	VBG
cord-016187-58rqc0cg	76	8	enzymes	enzyme	NNS
cord-016187-58rqc0cg	76	9	or	or	CC
cord-016187-58rqc0cg	76	10	synthetic	synthetic	JJ
cord-016187-58rqc0cg	76	11	enzymes	enzyme	NNS
cord-016187-58rqc0cg	76	12	with	with	IN
cord-016187-58rqc0cg	76	13	altered	alter	VBN
cord-016187-58rqc0cg	76	14	substrate	substrate	NN
cord-016187-58rqc0cg	76	15	specifi	specifi	NN
cord-016187-58rqc0cg	76	16	city	city	NN
cord-016187-58rqc0cg	76	17	by	by	IN
cord-016187-58rqc0cg	76	18	critical	critical	JJ
cord-016187-58rqc0cg	76	19	mutations	mutation	NNS
cord-016187-58rqc0cg	76	20	or	or	CC
cord-016187-58rqc0cg	76	21	recombination	recombination	NN
cord-016187-58rqc0cg	76	22	events	event	NNS
cord-016187-58rqc0cg	76	23	resulting	result	VBG
cord-016187-58rqc0cg	76	24	in	in	IN
cord-016187-58rqc0cg	76	25	the	the	DT
cord-016187-58rqc0cg	76	26	formation	formation	NN
cord-016187-58rqc0cg	76	27	of	of	IN
cord-016187-58rqc0cg	76	28	mosaic	mosaic	JJ
cord-016187-58rqc0cg	76	29	genes	gene	NNS
cord-016187-58rqc0cg	76	30	with	with	IN
cord-016187-58rqc0cg	76	31	entirely	entirely	RB
cord-016187-58rqc0cg	76	32	new	new	JJ
cord-016187-58rqc0cg	76	33	functions	function	NNS
cord-016187-58rqc0cg	76	34	[	[	-LRB-
cord-016187-58rqc0cg	76	35	30	30	CD
cord-016187-58rqc0cg	76	36	]	]	-RRB-
cord-016187-58rqc0cg	76	37	.	.	.
cord-016187-58rqc0cg	77	1	Altered	altered	JJ
cord-016187-58rqc0cg	77	2	penicillin	penicillin	NN
cord-016187-58rqc0cg	77	3	binding	bind	VBG
cord-016187-58rqc0cg	77	4	proteins	protein	NNS
cord-016187-58rqc0cg	77	5	that	that	WDT
cord-016187-58rqc0cg	77	6	mediate	mediate	VBP
cord-016187-58rqc0cg	77	7	beta	beta	NN
cord-016187-58rqc0cg	77	8	-	-	HYPH
cord-016187-58rqc0cg	77	9	lactam	lactam	NN
cord-016187-58rqc0cg	77	10	resistance	resistance	NN
cord-016187-58rqc0cg	77	11	in	in	IN
cord-016187-58rqc0cg	77	12	multiple	multiple	JJ
cord-016187-58rqc0cg	77	13	bacterial	bacterial	JJ
cord-016187-58rqc0cg	77	14	genera	genus	NNS
cord-016187-58rqc0cg	77	15	(	(	-LRB-
cord-016187-58rqc0cg	77	16	e.g.	e.g.	RB
cord-016187-58rqc0cg	77	17	,	,	,
cord-016187-58rqc0cg	77	18	methicillin	methicillin	NN
cord-016187-58rqc0cg	77	19	-	-	HYPH
cord-016187-58rqc0cg	77	20	resistant	resistant	JJ
cord-016187-58rqc0cg	77	21	S.	S.	NNP
cord-016187-58rqc0cg	77	22	aureus	aureus	NN
cord-016187-58rqc0cg	77	23	[	[	-LRB-
cord-016187-58rqc0cg	77	24	MRSA	MRSA	NNP
cord-016187-58rqc0cg	77	25	]	]	-RRB-
cord-016187-58rqc0cg	77	26	,	,	,
cord-016187-58rqc0cg	77	27	penicillin	penicillin	NN
cord-016187-58rqc0cg	77	28	-	-	HYPH
cord-016187-58rqc0cg	77	29	resistant	resistant	JJ
cord-016187-58rqc0cg	77	30	streptococci	streptococcus	NNS
cord-016187-58rqc0cg	77	31	and	and	CC
cord-016187-58rqc0cg	77	32	pneumococci	pneumococcus	NNS
cord-016187-58rqc0cg	77	33	,	,	,
cord-016187-58rqc0cg	77	34	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	77	35	resistance	resistance	NN
cord-016187-58rqc0cg	77	36	in	in	IN
cord-016187-58rqc0cg	77	37	gonococci	gonococci	NNP
cord-016187-58rqc0cg	77	38	)	)	-RRB-
cord-016187-58rqc0cg	77	39	may	may	MD
cord-016187-58rqc0cg	77	40	have	have	VB
cord-016187-58rqc0cg	77	41	evolved	evolve	VBN
cord-016187-58rqc0cg	77	42	from	from	IN
cord-016187-58rqc0cg	77	43	gene	gene	NN
cord-016187-58rqc0cg	77	44	fusions	fusion	NNS
cord-016187-58rqc0cg	77	45	for	for	IN
cord-016187-58rqc0cg	77	46	penicillin	penicillin	NN
cord-016187-58rqc0cg	77	47	binding	bind	VBG
cord-016187-58rqc0cg	77	48	proteins	protein	NNS
cord-016187-58rqc0cg	77	49	involved	involve	VBN
cord-016187-58rqc0cg	77	50	in	in	IN
cord-016187-58rqc0cg	77	51	bacterial	bacterial	JJ
cord-016187-58rqc0cg	77	52	cell	cell	NN
cord-016187-58rqc0cg	77	53	wall	wall	NN
cord-016187-58rqc0cg	77	54	synthesis	synthesis	NN
cord-016187-58rqc0cg	77	55	[	[	-LRB-
cord-016187-58rqc0cg	77	56	23	23	CD
cord-016187-58rqc0cg	77	57	]	]	-RRB-
cord-016187-58rqc0cg	77	58	.	.	.
cord-016187-58rqc0cg	78	1	Another	another	DT
cord-016187-58rqc0cg	78	2	common	common	JJ
cord-016187-58rqc0cg	78	3	resistance	resistance	NN
cord-016187-58rqc0cg	78	4	strategy	strategy	NN
cord-016187-58rqc0cg	78	5	is	be	VBZ
cord-016187-58rqc0cg	78	6	a	a	DT
cord-016187-58rqc0cg	78	7	change	change	NN
cord-016187-58rqc0cg	78	8	in	in	IN
cord-016187-58rqc0cg	78	9	the	the	DT
cord-016187-58rqc0cg	78	10	regulation	regulation	NN
cord-016187-58rqc0cg	78	11	of	of	IN
cord-016187-58rqc0cg	78	12	metabolic	metabolic	JJ
cord-016187-58rqc0cg	78	13	activity	activity	NN
cord-016187-58rqc0cg	78	14	of	of	IN
cord-016187-58rqc0cg	78	15	an	an	DT
cord-016187-58rqc0cg	78	16	enzyme	enzyme	NN
cord-016187-58rqc0cg	78	17	system	system	NN
cord-016187-58rqc0cg	78	18	that	that	WDT
cord-016187-58rqc0cg	78	19	is	be	VBZ
cord-016187-58rqc0cg	78	20	affected	affect	VBN
cord-016187-58rqc0cg	78	21	by	by	IN
cord-016187-58rqc0cg	78	22	the	the	DT
cord-016187-58rqc0cg	78	23	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	78	24	.	.	.
cord-016187-58rqc0cg	79	1	Increasing	increase	VBG
cord-016187-58rqc0cg	79	2	the	the	DT
cord-016187-58rqc0cg	79	3	rate	rate	NN
cord-016187-58rqc0cg	79	4	of	of	IN
cord-016187-58rqc0cg	79	5	folate	folate	NN
cord-016187-58rqc0cg	79	6	precursor	precursor	NN
cord-016187-58rqc0cg	79	7	synthesis	synthesis	NN
cord-016187-58rqc0cg	79	8	,	,	,
cord-016187-58rqc0cg	79	9	for	for	IN
cord-016187-58rqc0cg	79	10	example	example	NN
cord-016187-58rqc0cg	79	11	,	,	,
cord-016187-58rqc0cg	79	12	can	can	MD
cord-016187-58rqc0cg	79	13	overcome	overcome	VB
cord-016187-58rqc0cg	79	14	the	the	DT
cord-016187-58rqc0cg	79	15	inhibitor	inhibitor	NN
cord-016187-58rqc0cg	79	16	effects	effect	NNS
cord-016187-58rqc0cg	79	17	of	of	IN
cord-016187-58rqc0cg	79	18	sulfa	sulfa	NN
cord-016187-58rqc0cg	79	19	drugs	drug	NNS
cord-016187-58rqc0cg	79	20	and	and	CC
cord-016187-58rqc0cg	79	21	trimethoprim	trimethoprim	NNP
cord-016187-58rqc0cg	79	22	[	[	-LRB-
cord-016187-58rqc0cg	79	23	30	30	CD
cord-016187-58rqc0cg	79	24	]	]	-RRB-
cord-016187-58rqc0cg	79	25	.	.	.
cord-016187-58rqc0cg	80	1	Many	many	JJ
cord-016187-58rqc0cg	80	2	common	common	JJ
cord-016187-58rqc0cg	80	3	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	80	4	resistance	resistance	NN
cord-016187-58rqc0cg	80	5	genes	gene	NNS
cord-016187-58rqc0cg	80	6	were	be	VBD
cord-016187-58rqc0cg	80	7	accidentally	accidentally	RB
cord-016187-58rqc0cg	80	8	acquired	acquire	VBN
cord-016187-58rqc0cg	80	9	(	(	-LRB-
cord-016187-58rqc0cg	80	10	'	'	``
cord-016187-58rqc0cg	80	11	stolen	steal	VBN
cord-016187-58rqc0cg	80	12	'	'	''
cord-016187-58rqc0cg	80	13	)	)	-RRB-
cord-016187-58rqc0cg	80	14	from	from	IN
cord-016187-58rqc0cg	80	15	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	80	16	producing	produce	VBG
cord-016187-58rqc0cg	80	17	bacteria	bacteria	NNS
cord-016187-58rqc0cg	80	18	.	.	.
cord-016187-58rqc0cg	81	1	Streptomyces	streptomyce	NNS
cord-016187-58rqc0cg	81	2	and	and	CC
cord-016187-58rqc0cg	81	3	related	relate	VBN
cord-016187-58rqc0cg	81	4	soil	soil	NN
cord-016187-58rqc0cg	81	5	bacteria	bacteria	NNS
cord-016187-58rqc0cg	81	6	are	be	VBP
cord-016187-58rqc0cg	81	7	the	the	DT
cord-016187-58rqc0cg	81	8	source	source	NN
cord-016187-58rqc0cg	81	9	of	of	IN
cord-016187-58rqc0cg	81	10	many	many	JJ
cord-016187-58rqc0cg	81	11	standard	standard	JJ
cord-016187-58rqc0cg	81	12	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	81	13	agents	agent	NNS
cord-016187-58rqc0cg	81	14	in	in	IN
cord-016187-58rqc0cg	81	15	use	use	NN
cord-016187-58rqc0cg	81	16	in	in	IN
cord-016187-58rqc0cg	81	17	clinical	clinical	JJ
cord-016187-58rqc0cg	81	18	medicine	medicine	NN
cord-016187-58rqc0cg	81	19	today	today	NN
cord-016187-58rqc0cg	81	20	.	.	.
cord-016187-58rqc0cg	82	1	These	these	DT
cord-016187-58rqc0cg	82	2	bacteria	bacteria	NNS
cord-016187-58rqc0cg	82	3	have	have	VBP
cord-016187-58rqc0cg	82	4	co	co	VBN
cord-016187-58rqc0cg	82	5	-	-	VBN
cord-016187-58rqc0cg	82	6	evolved	evolve	VBD
cord-016187-58rqc0cg	82	7	the	the	DT
cord-016187-58rqc0cg	82	8	capacity	capacity	NN
cord-016187-58rqc0cg	82	9	to	to	TO
cord-016187-58rqc0cg	82	10	synthesize	synthesize	VB
cord-016187-58rqc0cg	82	11	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	82	12	along	along	IN
cord-016187-58rqc0cg	82	13	with	with	IN
cord-016187-58rqc0cg	82	14	the	the	DT
cord-016187-58rqc0cg	82	15	necessary	necessary	JJ
cord-016187-58rqc0cg	82	16	resistance	resistance	NN
cord-016187-58rqc0cg	82	17	genes	gene	NNS
cord-016187-58rqc0cg	82	18	to	to	TO
cord-016187-58rqc0cg	82	19	protect	protect	VB
cord-016187-58rqc0cg	82	20	their	-PRON-	PRP$
cord-016187-58rqc0cg	82	21	own	own	JJ
cord-016187-58rqc0cg	82	22	metabolic	metabolic	JJ
cord-016187-58rqc0cg	82	23	machinery	machinery	NN
cord-016187-58rqc0cg	82	24	from	from	IN
cord-016187-58rqc0cg	82	25	the	the	DT
cord-016187-58rqc0cg	82	26	very	very	RB
cord-016187-58rqc0cg	82	27	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	82	28	they	-PRON-	PRP
cord-016187-58rqc0cg	82	29	produce	produce	VBP
cord-016187-58rqc0cg	82	30	.	.	.
cord-016187-58rqc0cg	83	1	The	the	DT
cord-016187-58rqc0cg	83	2	resistance	resistance	NN
cord-016187-58rqc0cg	83	3	genes	gene	NNS
cord-016187-58rqc0cg	83	4	from	from	IN
cord-016187-58rqc0cg	83	5	these	these	DT
cord-016187-58rqc0cg	83	6	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	83	7	producing	produce	VBG
cord-016187-58rqc0cg	83	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	83	9	provide	provide	VBP
cord-016187-58rqc0cg	83	10	a	a	DT
cord-016187-58rqc0cg	83	11	ready	ready	JJ
cord-016187-58rqc0cg	83	12	genetic	genetic	JJ
cord-016187-58rqc0cg	83	13	blueprint	blueprint	NN
cord-016187-58rqc0cg	83	14	to	to	TO
cord-016187-58rqc0cg	83	15	resist	resist	VB
cord-016187-58rqc0cg	83	16	the	the	DT
cord-016187-58rqc0cg	83	17	target	target	NN
cord-016187-58rqc0cg	83	18	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	83	19	if	if	IN
cord-016187-58rqc0cg	83	20	susceptible	susceptible	JJ
cord-016187-58rqc0cg	83	21	bacteria	bacteria	NNS
cord-016187-58rqc0cg	83	22	can	can	MD
cord-016187-58rqc0cg	83	23	acquire	acquire	VB
cord-016187-58rqc0cg	83	24	these	these	DT
cord-016187-58rqc0cg	83	25	resistance	resistance	NN
cord-016187-58rqc0cg	83	26	genes	gene	NNS
cord-016187-58rqc0cg	83	27	.	.	.
cord-016187-58rqc0cg	84	1	Recent	recent	JJ
cord-016187-58rqc0cg	84	2	evidence	evidence	NN
cord-016187-58rqc0cg	84	3	confi	confi	NN
cord-016187-58rqc0cg	84	4	rming	rme	VBG
cord-016187-58rqc0cg	84	5	that	that	IN
cord-016187-58rqc0cg	84	6	this	this	DT
cord-016187-58rqc0cg	84	7	does	do	VBZ
cord-016187-58rqc0cg	84	8	indeed	indeed	RB
cord-016187-58rqc0cg	84	9	occur	occur	VB
cord-016187-58rqc0cg	84	10	was	be	VBD
cord-016187-58rqc0cg	84	11	found	find	VBN
cord-016187-58rqc0cg	84	12	by	by	IN
cord-016187-58rqc0cg	84	13	Yokoyama	Yokoyama	NNP
cord-016187-58rqc0cg	84	14	and	and	CC
cord-016187-58rqc0cg	84	15	colleagues	colleague	NNS
cord-016187-58rqc0cg	84	16	in	in	IN
cord-016187-58rqc0cg	84	17	Japan	Japan	NNP
cord-016187-58rqc0cg	84	18	during	during	IN
cord-016187-58rqc0cg	84	19	an	an	DT
cord-016187-58rqc0cg	84	20	investigation	investigation	NN
cord-016187-58rqc0cg	84	21	of	of	IN
cord-016187-58rqc0cg	84	22	a	a	DT
cord-016187-58rqc0cg	84	23	sudden	sudden	JJ
cord-016187-58rqc0cg	84	24	outbreak	outbreak	NN
cord-016187-58rqc0cg	84	25	of	of	IN
cord-016187-58rqc0cg	84	26	P.	p.	NN
cord-016187-58rqc0cg	84	27	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	84	28	with	with	IN
cord-016187-58rqc0cg	84	29	high	high	JJ
cord-016187-58rqc0cg	84	30	-	-	HYPH
cord-016187-58rqc0cg	84	31	level	level	NN
cord-016187-58rqc0cg	84	32	resistance	resistance	NN
cord-016187-58rqc0cg	84	33	to	to	IN
cord-016187-58rqc0cg	84	34	essentially	essentially	RB
cord-016187-58rqc0cg	84	35	all	all	PDT
cord-016187-58rqc0cg	84	36	the	the	DT
cord-016187-58rqc0cg	84	37	clinically	clinically	RB
cord-016187-58rqc0cg	84	38	available	available	JJ
cord-016187-58rqc0cg	84	39	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	84	40	[	[	-LRB-
cord-016187-58rqc0cg	84	41	31	31	CD
cord-016187-58rqc0cg	84	42	]	]	-RRB-
cord-016187-58rqc0cg	84	43	.	.	.
cord-016187-58rqc0cg	85	1	These	these	DT
cord-016187-58rqc0cg	85	2	investigators	investigator	NNS
cord-016187-58rqc0cg	85	3	discovered	discover	VBD
cord-016187-58rqc0cg	85	4	that	that	IN
cord-016187-58rqc0cg	85	5	the	the	DT
cord-016187-58rqc0cg	85	6	resistant	resistant	JJ
cord-016187-58rqc0cg	85	7	strain	strain	NN
cord-016187-58rqc0cg	85	8	had	have	VBD
cord-016187-58rqc0cg	85	9	acquired	acquire	VBN
cord-016187-58rqc0cg	85	10	a	a	DT
cord-016187-58rqc0cg	85	11	new	new	JJ
cord-016187-58rqc0cg	85	12	methylase	methylase	NN
cord-016187-58rqc0cg	85	13	gene	gene	NN
cord-016187-58rqc0cg	85	14	that	that	WDT
cord-016187-58rqc0cg	85	15	blocked	block	VBD
cord-016187-58rqc0cg	85	16	the	the	DT
cord-016187-58rqc0cg	85	17	binding	binding	NN
cord-016187-58rqc0cg	85	18	site	site	NN
cord-016187-58rqc0cg	85	19	for	for	IN
cord-016187-58rqc0cg	85	20	inhibition	inhibition	NN
cord-016187-58rqc0cg	85	21	by	by	IN
cord-016187-58rqc0cg	85	22	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	85	23	on	on	IN
cord-016187-58rqc0cg	85	24	a	a	DT
cord-016187-58rqc0cg	85	25	specifi	specifi	NN
cord-016187-58rqc0cg	85	26	c	c	NN
cord-016187-58rqc0cg	85	27	sequence	sequence	NN
cord-016187-58rqc0cg	85	28	on	on	IN
cord-016187-58rqc0cg	85	29	16S	16S	NNP
cord-016187-58rqc0cg	85	30	ribosomal	ribosomal	NNP
cord-016187-58rqc0cg	85	31	RNA	RNA	NNP
cord-016187-58rqc0cg	85	32	.	.	.
cord-016187-58rqc0cg	86	1	This	this	DT
cord-016187-58rqc0cg	86	2	identical	identical	JJ
cord-016187-58rqc0cg	86	3	mechanism	mechanism	NN
cord-016187-58rqc0cg	86	4	and	and	CC
cord-016187-58rqc0cg	86	5	highly	highly	RB
cord-016187-58rqc0cg	86	6	homologous	homologous	JJ
cord-016187-58rqc0cg	86	7	gene	gene	NN
cord-016187-58rqc0cg	86	8	is	be	VBZ
cord-016187-58rqc0cg	86	9	found	find	VBN
cord-016187-58rqc0cg	86	10	in	in	IN
cord-016187-58rqc0cg	86	11	aminoglycoside	aminoglycoside	RB
cord-016187-58rqc0cg	86	12	-	-	HYPH
cord-016187-58rqc0cg	86	13	producing	produce	VBG
cord-016187-58rqc0cg	86	14	strains	strain	NNS
cord-016187-58rqc0cg	86	15	of	of	IN
cord-016187-58rqc0cg	86	16	Streptomyces	Streptomyces	NNP
cord-016187-58rqc0cg	86	17	and	and	CC
cord-016187-58rqc0cg	86	18	related	relate	VBN
cord-016187-58rqc0cg	86	19	bacteria	bacteria	NNS
cord-016187-58rqc0cg	86	20	.	.	.
cord-016187-58rqc0cg	87	1	At	at	RB
cord-016187-58rqc0cg	87	2	least	least	JJS
cord-016187-58rqc0cg	87	3	seven	seven	CD
cord-016187-58rqc0cg	87	4	distinctive	distinctive	JJ
cord-016187-58rqc0cg	87	5	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	87	6	of	of	IN
cord-016187-58rqc0cg	87	7	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	87	8	resistance	resistance	NN
cord-016187-58rqc0cg	87	9	have	have	VBP
cord-016187-58rqc0cg	87	10	been	be	VBN
cord-016187-58rqc0cg	87	11	described	describe	VBN
cord-016187-58rqc0cg	87	12	in	in	IN
cord-016187-58rqc0cg	87	13	bacteria	bacteria	NNS
cord-016187-58rqc0cg	87	14	and	and	CC
cord-016187-58rqc0cg	87	15	are	be	VBP
cord-016187-58rqc0cg	87	16	summarized	summarize	VBN
cord-016187-58rqc0cg	87	17	on	on	IN
cord-016187-58rqc0cg	87	18	Table	Table	NNP
cord-016187-58rqc0cg	87	19	3	3	CD
cord-016187-58rqc0cg	87	20	.	.	.
cord-016187-58rqc0cg	88	1	Detoxifying	detoxify	VBG
cord-016187-58rqc0cg	88	2	enzymes	enzyme	NNS
cord-016187-58rqc0cg	88	3	are	be	VBP
cord-016187-58rqc0cg	88	4	used	use	VBN
cord-016187-58rqc0cg	88	5	to	to	TO
cord-016187-58rqc0cg	88	6	degrade	degrade	VB
cord-016187-58rqc0cg	88	7	beta	beta	NN
cord-016187-58rqc0cg	88	8	-	-	HYPH
cord-016187-58rqc0cg	88	9	lactams	lactam	NNS
cord-016187-58rqc0cg	88	10	[	[	-LRB-
cord-016187-58rqc0cg	88	11	24	24	CD
cord-016187-58rqc0cg	88	12	]	]	-RRB-
cord-016187-58rqc0cg	88	13	,	,	,
cord-016187-58rqc0cg	88	14	and	and	CC
cord-016187-58rqc0cg	88	15	modify	modify	VB
cord-016187-58rqc0cg	88	16	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	88	17	so	so	IN
cord-016187-58rqc0cg	88	18	they	-PRON-	PRP
cord-016187-58rqc0cg	88	19	no	no	RB
cord-016187-58rqc0cg	88	20	longer	longer	RB
cord-016187-58rqc0cg	88	21	enter	enter	VBP
cord-016187-58rqc0cg	88	22	bacterial	bacterial	JJ
cord-016187-58rqc0cg	88	23	membranes	membrane	NNS
cord-016187-58rqc0cg	88	24	and	and	CC
cord-016187-58rqc0cg	88	25	attach	attach	VB
cord-016187-58rqc0cg	88	26	to	to	IN
cord-016187-58rqc0cg	88	27	their	-PRON-	PRP$
cord-016187-58rqc0cg	88	28	ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	88	29	target	target	NN
cord-016187-58rqc0cg	88	30	.	.	.
cord-016187-58rqc0cg	89	1	There	there	EX
cord-016187-58rqc0cg	89	2	are	be	VBP
cord-016187-58rqc0cg	89	3	over	over	IN
cord-016187-58rqc0cg	89	4	30	30	CD
cord-016187-58rqc0cg	89	5	such	such	JJ
cord-016187-58rqc0cg	89	6	enzymes	enzyme	NNS
cord-016187-58rqc0cg	89	7	identifi	identifi	NN
cord-016187-58rqc0cg	89	8	ed	ed	NN
cord-016187-58rqc0cg	89	9	that	that	WDT
cord-016187-58rqc0cg	89	10	can	can	MD
cord-016187-58rqc0cg	89	11	inhibit	inhibit	VB
cord-016187-58rqc0cg	89	12	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	89	13	by	by	IN
cord-016187-58rqc0cg	89	14	one	one	CD
cord-016187-58rqc0cg	89	15	of	of	IN
cord-016187-58rqc0cg	89	16	three	three	CD
cord-016187-58rqc0cg	89	17	general	general	JJ
cord-016187-58rqc0cg	89	18	reactions	reaction	NNS
cord-016187-58rqc0cg	89	19	:	:	:
cord-016187-58rqc0cg	89	20	N	n	CD
cord-016187-58rqc0cg	89	21	-	-	HYPH
cord-016187-58rqc0cg	89	22	acetylation	acetylation	NN
cord-016187-58rqc0cg	89	23	,	,	,
cord-016187-58rqc0cg	89	24	O	o	NN
cord-016187-58rqc0cg	89	25	-	-	HYPH
cord-016187-58rqc0cg	89	26	nucleotidylation	nucleotidylation	NN
cord-016187-58rqc0cg	89	27	,	,	,
cord-016187-58rqc0cg	89	28	and	and	CC
cord-016187-58rqc0cg	89	29	O	o	NN
cord-016187-58rqc0cg	89	30	-	-	HYPH
cord-016187-58rqc0cg	89	31	phosphorylation	phosphorylation	NN
cord-016187-58rqc0cg	89	32	[	[	-LRB-
cord-016187-58rqc0cg	89	33	23	23	CD
cord-016187-58rqc0cg	89	34	]	]	-RRB-
cord-016187-58rqc0cg	89	35	.	.	.
cord-016187-58rqc0cg	90	1	Detoxifying	detoxify	VBG
cord-016187-58rqc0cg	90	2	enzymes	enzyme	NNS
cord-016187-58rqc0cg	90	3	are	be	VBP
cord-016187-58rqc0cg	90	4	also	also	RB
cord-016187-58rqc0cg	90	5	one	one	CD
cord-016187-58rqc0cg	90	6	of	of	IN
cord-016187-58rqc0cg	90	7	the	the	DT
cord-016187-58rqc0cg	90	8	resistance	resistance	NN
cord-016187-58rqc0cg	90	9	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	90	10	against	against	IN
cord-016187-58rqc0cg	90	11	chloramphenicol	chloramphenicol	NN
cord-016187-58rqc0cg	90	12	,	,	,
cord-016187-58rqc0cg	90	13	and	and	CC
cord-016187-58rqc0cg	90	14	are	be	VBP
cord-016187-58rqc0cg	90	15	rarely	rarely	RB
cord-016187-58rqc0cg	90	16	utilized	utilize	VBN
cord-016187-58rqc0cg	90	17	by	by	IN
cord-016187-58rqc0cg	90	18	certain	certain	JJ
cord-016187-58rqc0cg	90	19	bacterial	bacterial	JJ
cord-016187-58rqc0cg	90	20	strains	strain	NNS
cord-016187-58rqc0cg	90	21	to	to	TO
cord-016187-58rqc0cg	90	22	inactivate	inactivate	VB
cord-016187-58rqc0cg	90	23	macrolides	macrolide	NNS
cord-016187-58rqc0cg	90	24	,	,	,
cord-016187-58rqc0cg	90	25	lincosamides	lincosamide	NNS
cord-016187-58rqc0cg	90	26	,	,	,
cord-016187-58rqc0cg	90	27	tetracyclines	tetracycline	NNS
cord-016187-58rqc0cg	90	28	and	and	CC
cord-016187-58rqc0cg	90	29	streptogramins	streptogramin	NNS
cord-016187-58rqc0cg	90	30	.	.	.
cord-016187-58rqc0cg	91	1	It	-PRON-	PRP
cord-016187-58rqc0cg	91	2	was	be	VBD
cord-016187-58rqc0cg	91	3	recognized	recognize	VBN
cord-016187-58rqc0cg	91	4	early	early	RB
cord-016187-58rqc0cg	91	5	in	in	IN
cord-016187-58rqc0cg	91	6	the	the	DT
cord-016187-58rqc0cg	91	7	history	history	NN
cord-016187-58rqc0cg	91	8	of	of	IN
cord-016187-58rqc0cg	91	9	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	91	10	development	development	NN
cord-016187-58rqc0cg	91	11	that	that	WDT
cord-016187-58rqc0cg	91	12	penicillin	penicillin	NN
cord-016187-58rqc0cg	91	13	is	be	VBZ
cord-016187-58rqc0cg	91	14	effective	effective	JJ
cord-016187-58rqc0cg	91	15	against	against	IN
cord-016187-58rqc0cg	91	16	Gram	gram	NN
cord-016187-58rqc0cg	91	17	-	-	HYPH
cord-016187-58rqc0cg	91	18	positive	positive	JJ
cord-016187-58rqc0cg	91	19	bacteria	bacteria	NNS
cord-016187-58rqc0cg	91	20	but	but	CC
cord-016187-58rqc0cg	91	21	not	not	RB
cord-016187-58rqc0cg	91	22	against	against	IN
cord-016187-58rqc0cg	91	23	Gram	gram	NN
cord-016187-58rqc0cg	91	24	-	-	HYPH
cord-016187-58rqc0cg	91	25	negative	negative	JJ
cord-016187-58rqc0cg	91	26	bacteria	bacteria	NNS
cord-016187-58rqc0cg	91	27	[	[	-LRB-
cord-016187-58rqc0cg	91	28	23	23	CD
cord-016187-58rqc0cg	91	29	]	]	-RRB-
cord-016187-58rqc0cg	91	30	.	.	.
cord-016187-58rqc0cg	92	1	This	this	DT
cord-016187-58rqc0cg	92	2	difference	difference	NN
cord-016187-58rqc0cg	92	3	in	in	IN
cord-016187-58rqc0cg	92	4	susceptibility	susceptibility	NN
cord-016187-58rqc0cg	92	5	to	to	IN
cord-016187-58rqc0cg	92	6	penicillin	penicillin	NN
cord-016187-58rqc0cg	92	7	is	be	VBZ
cord-016187-58rqc0cg	92	8	due	due	JJ
cord-016187-58rqc0cg	92	9	in	in	IN
cord-016187-58rqc0cg	92	10	large	large	JJ
cord-016187-58rqc0cg	92	11	part	part	NN
cord-016187-58rqc0cg	92	12	to	to	IN
cord-016187-58rqc0cg	92	13	the	the	DT
cord-016187-58rqc0cg	92	14	outer	outer	JJ
cord-016187-58rqc0cg	92	15	membrane	membrane	NN
cord-016187-58rqc0cg	92	16	,	,	,
cord-016187-58rqc0cg	92	17	a	a	DT
cord-016187-58rqc0cg	92	18	lipid	lipid	NN
cord-016187-58rqc0cg	92	19	bilayer	bilayer	NN
cord-016187-58rqc0cg	92	20	that	that	WDT
cord-016187-58rqc0cg	92	21	acts	act	VBZ
cord-016187-58rqc0cg	92	22	as	as	IN
cord-016187-58rqc0cg	92	23	a	a	DT
cord-016187-58rqc0cg	92	24	barrier	barrier	NN
cord-016187-58rqc0cg	92	25	to	to	IN
cord-016187-58rqc0cg	92	26	the	the	DT
cord-016187-58rqc0cg	92	27	penetration	penetration	NN
cord-016187-58rqc0cg	92	28	of	of	IN
cord-016187-58rqc0cg	92	29	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	92	30	into	into	IN
cord-016187-58rqc0cg	92	31	the	the	DT
cord-016187-58rqc0cg	92	32	cell	cell	NN
cord-016187-58rqc0cg	92	33	.	.	.
cord-016187-58rqc0cg	93	1	Situated	situate	VBN
cord-016187-58rqc0cg	93	2	outside	outside	IN
cord-016187-58rqc0cg	93	3	the	the	DT
cord-016187-58rqc0cg	93	4	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	93	5	cell	cell	NN
cord-016187-58rqc0cg	93	6	wall	wall	NN
cord-016187-58rqc0cg	93	7	of	of	IN
cord-016187-58rqc0cg	93	8	Gramnegative	Gramnegative	NNP
cord-016187-58rqc0cg	93	9	bacteria	bacteria	NNS
cord-016187-58rqc0cg	93	10	,	,	,
cord-016187-58rqc0cg	93	11	this	this	DT
cord-016187-58rqc0cg	93	12	outer	outer	JJ
cord-016187-58rqc0cg	93	13	membrane	membrane	NN
cord-016187-58rqc0cg	93	14	is	be	VBZ
cord-016187-58rqc0cg	93	15	absent	absent	JJ
cord-016187-58rqc0cg	93	16	in	in	IN
cord-016187-58rqc0cg	93	17	Gram	gram	NN
cord-016187-58rqc0cg	93	18	-	-	HYPH
cord-016187-58rqc0cg	93	19	positive	positive	JJ
cord-016187-58rqc0cg	93	20	bacteria	bacteria	NNS
cord-016187-58rqc0cg	93	21	.	.	.
cord-016187-58rqc0cg	94	1	The	the	DT
cord-016187-58rqc0cg	94	2	outer	outer	JJ
cord-016187-58rqc0cg	94	3	portion	portion	NN
cord-016187-58rqc0cg	94	4	of	of	IN
cord-016187-58rqc0cg	94	5	this	this	DT
cord-016187-58rqc0cg	94	6	lipid	lipid	NN
cord-016187-58rqc0cg	94	7	bilayer	bilayer	NN
cord-016187-58rqc0cg	94	8	is	be	VBZ
cord-016187-58rqc0cg	94	9	composed	compose	VBN
cord-016187-58rqc0cg	94	10	principally	principally	RB
cord-016187-58rqc0cg	94	11	of	of	IN
cord-016187-58rqc0cg	94	12	lipopolysaccharide	lipopolysaccharide	NN
cord-016187-58rqc0cg	94	13	(	(	-LRB-
cord-016187-58rqc0cg	94	14	LPS	LPS	NNP
cord-016187-58rqc0cg	94	15	)	)	-RRB-
cord-016187-58rqc0cg	94	16	made	make	VBD
cord-016187-58rqc0cg	94	17	up	up	RP
cord-016187-58rqc0cg	94	18	of	of	IN
cord-016187-58rqc0cg	94	19	tightly	tightly	RB
cord-016187-58rqc0cg	94	20	bound	bind	VBN
cord-016187-58rqc0cg	94	21	hydrocarbon	hydrocarbon	NN
cord-016187-58rqc0cg	94	22	molecules	molecule	NNS
cord-016187-58rqc0cg	94	23	that	that	WDT
cord-016187-58rqc0cg	94	24	impede	impede	VBP
cord-016187-58rqc0cg	94	25	the	the	DT
cord-016187-58rqc0cg	94	26	entry	entry	NN
cord-016187-58rqc0cg	94	27	of	of	IN
cord-016187-58rqc0cg	94	28	hydrophobic	hydrophobic	JJ
cord-016187-58rqc0cg	94	29	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	94	30	,	,	,
cord-016187-58rqc0cg	94	31	such	such	JJ
cord-016187-58rqc0cg	94	32	as	as	IN
cord-016187-58rqc0cg	94	33	penicillins	penicillin	NNS
cord-016187-58rqc0cg	94	34	or	or	CC
cord-016187-58rqc0cg	94	35	macrolides	macrolide	NNS
cord-016187-58rqc0cg	94	36	.	.	.
cord-016187-58rqc0cg	95	1	The	the	DT
cord-016187-58rqc0cg	95	2	passage	passage	NN
cord-016187-58rqc0cg	95	3	of	of	IN
cord-016187-58rqc0cg	95	4	hydrophilic	hydrophilic	JJ
cord-016187-58rqc0cg	95	5	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	95	6	through	through	IN
cord-016187-58rqc0cg	95	7	this	this	DT
cord-016187-58rqc0cg	95	8	outer	outer	JJ
cord-016187-58rqc0cg	95	9	membrane	membrane	NN
cord-016187-58rqc0cg	95	10	is	be	VBZ
cord-016187-58rqc0cg	95	11	facilitated	facilitate	VBN
cord-016187-58rqc0cg	95	12	by	by	IN
cord-016187-58rqc0cg	95	13	the	the	DT
cord-016187-58rqc0cg	95	14	presence	presence	NN
cord-016187-58rqc0cg	95	15	of	of	IN
cord-016187-58rqc0cg	95	16	porins	porins	NNP
cord-016187-58rqc0cg	95	17	,	,	,
cord-016187-58rqc0cg	95	18	proteins	protein	NNS
cord-016187-58rqc0cg	95	19	that	that	WDT
cord-016187-58rqc0cg	95	20	are	be	VBP
cord-016187-58rqc0cg	95	21	arranged	arrange	VBN
cord-016187-58rqc0cg	95	22	so	so	IN
cord-016187-58rqc0cg	95	23	as	as	IN
cord-016187-58rqc0cg	95	24	to	to	TO
cord-016187-58rqc0cg	95	25	form	form	VB
cord-016187-58rqc0cg	95	26	water	water	NN
cord-016187-58rqc0cg	95	27	-	-	HYPH
cord-016187-58rqc0cg	95	28	fi	fi	NN
cord-016187-58rqc0cg	95	29	lled	lled	JJ
cord-016187-58rqc0cg	95	30	diffusion	diffusion	NN
cord-016187-58rqc0cg	95	31	channels	channel	NNS
cord-016187-58rqc0cg	95	32	through	through	IN
cord-016187-58rqc0cg	95	33	which	which	WDT
cord-016187-58rqc0cg	95	34	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	95	35	may	may	MD
cord-016187-58rqc0cg	95	36	traverse	traverse	VB
cord-016187-58rqc0cg	95	37	[	[	-LRB-
cord-016187-58rqc0cg	95	38	23	23	CD
cord-016187-58rqc0cg	95	39	]	]	-RRB-
cord-016187-58rqc0cg	95	40	.	.	.
cord-016187-58rqc0cg	96	1	Bacteria	Bacteria	NNS
cord-016187-58rqc0cg	96	2	usually	usually	RB
cord-016187-58rqc0cg	96	3	produce	produce	VBP
cord-016187-58rqc0cg	96	4	a	a	DT
cord-016187-58rqc0cg	96	5	large	large	JJ
cord-016187-58rqc0cg	96	6	number	number	NN
cord-016187-58rqc0cg	96	7	of	of	IN
cord-016187-58rqc0cg	96	8	porins	porin	NNS
cord-016187-58rqc0cg	96	9	with	with	IN
cord-016187-58rqc0cg	96	10	differing	differ	VBG
cord-016187-58rqc0cg	96	11	physiochemical	physiochemical	JJ
cord-016187-58rqc0cg	96	12	properties	property	NNS
cord-016187-58rqc0cg	96	13	,	,	,
cord-016187-58rqc0cg	96	14	permeability	permeability	NN
cord-016187-58rqc0cg	96	15	characteristics	characteristic	NNS
cord-016187-58rqc0cg	96	16	and	and	CC
cord-016187-58rqc0cg	96	17	size	size	NN
cord-016187-58rqc0cg	96	18	;	;	:
cord-016187-58rqc0cg	96	19	approximately	approximately	RB
cord-016187-58rqc0cg	96	20	10	10	CD
cord-016187-58rqc0cg	96	21	5	5	CD
cord-016187-58rqc0cg	96	22	porin	porin	NNS
cord-016187-58rqc0cg	96	23	molecules/	molecules/	CD
cord-016187-58rqc0cg	96	24	cell	cell	NN
cord-016187-58rqc0cg	96	25	for	for	IN
cord-016187-58rqc0cg	96	26	Escherichia	escherichia	NN
cord-016187-58rqc0cg	96	27	coli	coli	NNS
cord-016187-58rqc0cg	96	28	.	.	.
cord-016187-58rqc0cg	97	1	Bacteria	Bacteria	NNS
cord-016187-58rqc0cg	97	2	are	be	VBP
cord-016187-58rqc0cg	97	3	able	able	JJ
cord-016187-58rqc0cg	97	4	to	to	TO
cord-016187-58rqc0cg	97	5	regulate	regulate	VB
cord-016187-58rqc0cg	97	6	the	the	DT
cord-016187-58rqc0cg	97	7	relative	relative	JJ
cord-016187-58rqc0cg	97	8	number	number	NN
cord-016187-58rqc0cg	97	9	of	of	IN
cord-016187-58rqc0cg	97	10	different	different	JJ
cord-016187-58rqc0cg	97	11	porins	porin	NNS
cord-016187-58rqc0cg	97	12	in	in	IN
cord-016187-58rqc0cg	97	13	response	response	NN
cord-016187-58rqc0cg	97	14	to	to	IN
cord-016187-58rqc0cg	97	15	the	the	DT
cord-016187-58rqc0cg	97	16	osmolarity	osmolarity	NN
cord-016187-58rqc0cg	97	17	of	of	IN
cord-016187-58rqc0cg	97	18	their	-PRON-	PRP$
cord-016187-58rqc0cg	97	19	microenvironment	microenvironment	NN
cord-016187-58rqc0cg	97	20	.	.	.
cord-016187-58rqc0cg	98	1	In	in	IN
cord-016187-58rqc0cg	98	2	hyperosmolar	hyperosmolar	JJ
cord-016187-58rqc0cg	98	3	conditions	condition	NNS
cord-016187-58rqc0cg	98	4	,	,	,
cord-016187-58rqc0cg	98	5	E.	E.	NNP
cord-016187-58rqc0cg	98	6	coli	coli	NNS
cord-016187-58rqc0cg	98	7	represses	repress	VBZ
cord-016187-58rqc0cg	98	8	the	the	DT
cord-016187-58rqc0cg	98	9	synthesis	synthesis	NN
cord-016187-58rqc0cg	98	10	of	of	IN
cord-016187-58rqc0cg	98	11	larger	large	JJR
cord-016187-58rqc0cg	98	12	porins	porin	NNS
cord-016187-58rqc0cg	98	13	(	(	-LRB-
cord-016187-58rqc0cg	98	14	OmpF	OmpF	NNP
cord-016187-58rqc0cg	98	15	)	)	-RRB-
cord-016187-58rqc0cg	98	16	while	while	IN
cord-016187-58rqc0cg	98	17	continuing	continue	VBG
cord-016187-58rqc0cg	98	18	to	to	TO
cord-016187-58rqc0cg	98	19	express	express	VB
cord-016187-58rqc0cg	98	20	smaller	small	JJR
cord-016187-58rqc0cg	98	21	ones	one	NNS
cord-016187-58rqc0cg	98	22	(	(	-LRB-
cord-016187-58rqc0cg	98	23	OmpC	OmpC	NNP
cord-016187-58rqc0cg	98	24	)	)	-RRB-
cord-016187-58rqc0cg	98	25	[	[	-LRB-
cord-016187-58rqc0cg	98	26	32	32	CD
cord-016187-58rqc0cg	98	27	]	]	-RRB-
cord-016187-58rqc0cg	98	28	.	.	.
cord-016187-58rqc0cg	99	1	Mutations	mutation	NNS
cord-016187-58rqc0cg	99	2	resulting	result	VBG
cord-016187-58rqc0cg	99	3	in	in	IN
cord-016187-58rqc0cg	99	4	the	the	DT
cord-016187-58rqc0cg	99	5	loss	loss	NN
cord-016187-58rqc0cg	99	6	of	of	IN
cord-016187-58rqc0cg	99	7	specifi	specifi	NNP
cord-016187-58rqc0cg	99	8	c	c	NN
cord-016187-58rqc0cg	99	9	porins	porins	NNP
cord-016187-58rqc0cg	99	10	can	can	MD
cord-016187-58rqc0cg	99	11	occur	occur	VB
cord-016187-58rqc0cg	99	12	in	in	IN
cord-016187-58rqc0cg	99	13	clinical	clinical	JJ
cord-016187-58rqc0cg	99	14	isolates	isolate	NNS
cord-016187-58rqc0cg	99	15	and	and	CC
cord-016187-58rqc0cg	99	16	determine	determine	VB
cord-016187-58rqc0cg	99	17	increased	increase	VBN
cord-016187-58rqc0cg	99	18	resistance	resistance	NN
cord-016187-58rqc0cg	99	19	to	to	IN
cord-016187-58rqc0cg	99	20	beta	beta	NN
cord-016187-58rqc0cg	99	21	-	-	HYPH
cord-016187-58rqc0cg	99	22	lactam	lactam	NN
cord-016187-58rqc0cg	99	23	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	99	24	.	.	.
cord-016187-58rqc0cg	100	1	Resistance	resistance	NN
cord-016187-58rqc0cg	100	2	to	to	IN
cord-016187-58rqc0cg	100	3	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	100	4	and	and	CC
cord-016187-58rqc0cg	100	5	carbapenems	carbapenem	NNS
cord-016187-58rqc0cg	100	6	emerging	emerge	VBG
cord-016187-58rqc0cg	100	7	during	during	IN
cord-016187-58rqc0cg	100	8	therapy	therapy	NN
cord-016187-58rqc0cg	100	9	has	have	VBZ
cord-016187-58rqc0cg	100	10	also	also	RB
cord-016187-58rqc0cg	100	11	been	be	VBN
cord-016187-58rqc0cg	100	12	associated	associate	VBN
cord-016187-58rqc0cg	100	13	with	with	IN
cord-016187-58rqc0cg	100	14	a	a	DT
cord-016187-58rqc0cg	100	15	lack	lack	NN
cord-016187-58rqc0cg	100	16	of	of	IN
cord-016187-58rqc0cg	100	17	production	production	NN
cord-016187-58rqc0cg	100	18	of	of	IN
cord-016187-58rqc0cg	100	19	outer	outer	JJ
cord-016187-58rqc0cg	100	20	membrane	membrane	NN
cord-016187-58rqc0cg	100	21	proteins	protein	NNS
cord-016187-58rqc0cg	100	22	.	.	.
cord-016187-58rqc0cg	101	1	In	in	IN
cord-016187-58rqc0cg	101	2	P.	P.	NNP
cord-016187-58rqc0cg	101	3	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	101	4	,	,	,
cord-016187-58rqc0cg	101	5	resistance	resistance	NN
cord-016187-58rqc0cg	101	6	to	to	IN
cord-016187-58rqc0cg	101	7	imipenem	imipenem	NNP
cord-016187-58rqc0cg	101	8	appears	appear	VBZ
cord-016187-58rqc0cg	101	9	to	to	TO
cord-016187-58rqc0cg	101	10	be	be	VB
cord-016187-58rqc0cg	101	11	due	due	JJ
cord-016187-58rqc0cg	101	12	to	to	IN
cord-016187-58rqc0cg	101	13	an	an	DT
cord-016187-58rqc0cg	101	14	interaction	interaction	NN
cord-016187-58rqc0cg	101	15	between	between	IN
cord-016187-58rqc0cg	101	16	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	101	17	beta	beta	NN
cord-016187-58rqc0cg	101	18	-	-	HYPH
cord-016187-58rqc0cg	101	19	lactamase	lactamase	NN
cord-016187-58rqc0cg	101	20	activity	activity	NN
cord-016187-58rqc0cg	101	21	and	and	CC
cord-016187-58rqc0cg	101	22	a	a	DT
cord-016187-58rqc0cg	101	23	loss	loss	NN
cord-016187-58rqc0cg	101	24	of	of	IN
cord-016187-58rqc0cg	101	25	a	a	DT
cord-016187-58rqc0cg	101	26	specifi	specifi	NN
cord-016187-58rqc0cg	101	27	c	c	NN
cord-016187-58rqc0cg	101	28	entry	entry	NN
cord-016187-58rqc0cg	101	29	channel	channel	NN
cord-016187-58rqc0cg	101	30	,	,	,
cord-016187-58rqc0cg	101	31	the	the	DT
cord-016187-58rqc0cg	101	32	D2	D2	NNP
cord-016187-58rqc0cg	101	33	porin	porin	NN
cord-016187-58rqc0cg	101	34	[	[	-LRB-
cord-016187-58rqc0cg	101	35	33	33	CD
cord-016187-58rqc0cg	101	36	]	]	-RRB-
cord-016187-58rqc0cg	101	37	.	.	.
cord-016187-58rqc0cg	102	1	The	the	DT
cord-016187-58rqc0cg	102	2	rate	rate	NN
cord-016187-58rqc0cg	102	3	of	of	IN
cord-016187-58rqc0cg	102	4	entry	entry	NN
cord-016187-58rqc0cg	102	5	of	of	IN
cord-016187-58rqc0cg	102	6	aminoglycoside	aminoglycoside	JJ
cord-016187-58rqc0cg	102	7	molecules	molecule	NNS
cord-016187-58rqc0cg	102	8	into	into	IN
cord-016187-58rqc0cg	102	9	bacterial	bacterial	JJ
cord-016187-58rqc0cg	102	10	cells	cell	NNS
cord-016187-58rqc0cg	102	11	is	be	VBZ
cord-016187-58rqc0cg	102	12	a	a	DT
cord-016187-58rqc0cg	102	13	function	function	NN
cord-016187-58rqc0cg	102	14	of	of	IN
cord-016187-58rqc0cg	102	15	their	-PRON-	PRP$
cord-016187-58rqc0cg	102	16	binding	binding	NN
cord-016187-58rqc0cg	102	17	to	to	IN
cord-016187-58rqc0cg	102	18	a	a	DT
cord-016187-58rqc0cg	102	19	usually	usually	RB
cord-016187-58rqc0cg	102	20	non	non	JJ
cord-016187-58rqc0cg	102	21	-	-	JJ
cord-016187-58rqc0cg	102	22	saturable	saturable	JJ
cord-016187-58rqc0cg	102	23	anionic	anionic	JJ
cord-016187-58rqc0cg	102	24	transporter	transporter	NN
cord-016187-58rqc0cg	102	25	,	,	,
cord-016187-58rqc0cg	102	26	whereupon	whereupon	RB
cord-016187-58rqc0cg	102	27	they	-PRON-	PRP
cord-016187-58rqc0cg	102	28	retain	retain	VBP
cord-016187-58rqc0cg	102	29	their	-PRON-	PRP$
cord-016187-58rqc0cg	102	30	positive	positive	JJ
cord-016187-58rqc0cg	102	31	charge	charge	NN
cord-016187-58rqc0cg	102	32	and	and	CC
cord-016187-58rqc0cg	102	33	are	be	VBP
cord-016187-58rqc0cg	102	34	subsequently	subsequently	RB
cord-016187-58rqc0cg	102	35	'	'	``
cord-016187-58rqc0cg	102	36	pulled	pull	VBN
cord-016187-58rqc0cg	102	37	'	'	''
cord-016187-58rqc0cg	102	38	across	across	IN
cord-016187-58rqc0cg	102	39	the	the	DT
cord-016187-58rqc0cg	102	40	cytoplasmic	cytoplasmic	JJ
cord-016187-58rqc0cg	102	41	membrane	membrane	NN
cord-016187-58rqc0cg	102	42	by	by	IN
cord-016187-58rqc0cg	102	43	the	the	DT
cord-016187-58rqc0cg	102	44	internal	internal	JJ
cord-016187-58rqc0cg	102	45	negative	negative	JJ
cord-016187-58rqc0cg	102	46	charge	charge	NN
cord-016187-58rqc0cg	102	47	of	of	IN
cord-016187-58rqc0cg	102	48	the	the	DT
cord-016187-58rqc0cg	102	49	cell	cell	NN
cord-016187-58rqc0cg	102	50	.	.	.
cord-016187-58rqc0cg	103	1	This	this	DT
cord-016187-58rqc0cg	103	2	process	process	NN
cord-016187-58rqc0cg	103	3	requires	require	VBZ
cord-016187-58rqc0cg	103	4	energy	energy	NN
cord-016187-58rqc0cg	103	5	and	and	CC
cord-016187-58rqc0cg	103	6	a	a	DT
cord-016187-58rqc0cg	103	7	threshold	threshold	NN
cord-016187-58rqc0cg	103	8	level	level	NN
cord-016187-58rqc0cg	103	9	of	of	IN
cord-016187-58rqc0cg	103	10	internal	internal	JJ
cord-016187-58rqc0cg	103	11	negative	negative	JJ
cord-016187-58rqc0cg	103	12	charge	charge	NN
cord-016187-58rqc0cg	103	13	before	before	IN
cord-016187-58rqc0cg	103	14	signifi	signifi	NNP
cord-016187-58rqc0cg	103	15	ca	ca	NNP
cord-016187-58rqc0cg	104	1	nt	nt	RB
cord-016187-58rqc0cg	104	2	transport	transport	NN
cord-016187-58rqc0cg	104	3	occurs	occur	VBZ
cord-016187-58rqc0cg	104	4	(	(	-LRB-
cord-016187-58rqc0cg	104	5	proton	proton	NN
cord-016187-58rqc0cg	104	6	motive	motive	NN
cord-016187-58rqc0cg	104	7	force	force	NN
cord-016187-58rqc0cg	104	8	)	)	-RRB-
cord-016187-58rqc0cg	105	1	[	[	-LRB-
cord-016187-58rqc0cg	105	2	34	34	CD
cord-016187-58rqc0cg	105	3	]	]	-RRB-
cord-016187-58rqc0cg	105	4	.	.	.
cord-016187-58rqc0cg	106	1	These	these	DT
cord-016187-58rqc0cg	106	2	aminoglycoside	aminoglycoside	JJ
cord-016187-58rqc0cg	106	3	-	-	HYPH
cord-016187-58rqc0cg	106	4	resistant	resistant	JJ
cord-016187-58rqc0cg	106	5	isolates	isolate	NNS
cord-016187-58rqc0cg	106	6	with	with	IN
cord-016187-58rqc0cg	106	7	altered	altered	JJ
cord-016187-58rqc0cg	106	8	proton	proton	NN
cord-016187-58rqc0cg	106	9	motive	motive	NN
cord-016187-58rqc0cg	106	10	force	force	NN
cord-016187-58rqc0cg	106	11	may	may	MD
cord-016187-58rqc0cg	106	12	occur	occur	VB
cord-016187-58rqc0cg	106	13	during	during	IN
cord-016187-58rqc0cg	106	14	long	long	JJ
cord-016187-58rqc0cg	106	15	-	-	HYPH
cord-016187-58rqc0cg	106	16	term	term	NN
cord-016187-58rqc0cg	106	17	aminoglycoside	aminoglycoside	NN
cord-016187-58rqc0cg	106	18	therapy	therapy	NN
cord-016187-58rqc0cg	106	19	.	.	.
cord-016187-58rqc0cg	107	1	These	these	DT
cord-016187-58rqc0cg	107	2	isolates	isolate	NNS
cord-016187-58rqc0cg	107	3	usually	usually	RB
cord-016187-58rqc0cg	107	4	have	have	VBP
cord-016187-58rqc0cg	107	5	a	a	DT
cord-016187-58rqc0cg	107	6	'	'	``
cord-016187-58rqc0cg	107	7	small	small	JJ
cord-016187-58rqc0cg	107	8	colony	colony	NN
cord-016187-58rqc0cg	107	9	'	'	''
cord-016187-58rqc0cg	107	10	phenotype	phenotype	NN
cord-016187-58rqc0cg	107	11	due	due	IN
cord-016187-58rqc0cg	107	12	to	to	IN
cord-016187-58rqc0cg	107	13	their	-PRON-	PRP$
cord-016187-58rqc0cg	107	14	reduced	reduce	VBN
cord-016187-58rqc0cg	107	15	rate	rate	NN
cord-016187-58rqc0cg	107	16	of	of	IN
cord-016187-58rqc0cg	107	17	growth	growth	NN
cord-016187-58rqc0cg	107	18	.	.	.
cord-016187-58rqc0cg	108	1	Im-	im-	XX
cord-016187-58rqc0cg	109	1	Gram	gram	NN
cord-016187-58rqc0cg	109	2	-	-	HYPH
cord-016187-58rqc0cg	109	3	neg	neg	NN
cord-016187-58rqc0cg	109	4	:	:	:
cord-016187-58rqc0cg	109	5	Gram	gram	NN
cord-016187-58rqc0cg	109	6	-	-	HYPH
cord-016187-58rqc0cg	109	7	negative	negative	JJ
cord-016187-58rqc0cg	109	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	109	9	;	;	:
cord-016187-58rqc0cg	109	10	TMP	tmp	NN
cord-016187-58rqc0cg	109	11	:	:	:
cord-016187-58rqc0cg	109	12	trimethoprim	trimethoprim	NN
cord-016187-58rqc0cg	109	13	;	;	:
cord-016187-58rqc0cg	109	14	TCN	tcn	NN
cord-016187-58rqc0cg	109	15	:	:	:
cord-016187-58rqc0cg	109	16	tetracycline	tetracycline	NN
cord-016187-58rqc0cg	109	17	;	;	.
cord-016187-58rqc0cg	110	1	+	+	CC
cord-016187-58rqc0cg	111	1	+	+	CC
cord-016187-58rqc0cg	111	2	+	+	CC
cord-016187-58rqc0cg	111	3	:	:	:
cord-016187-58rqc0cg	111	4	most	most	RBS
cord-016187-58rqc0cg	111	5	common	common	JJ
cord-016187-58rqc0cg	111	6	mechanism	mechanism	NN
cord-016187-58rqc0cg	111	7	;	;	:
cord-016187-58rqc0cg	111	8	+	+	SYM
cord-016187-58rqc0cg	111	9	+	+	CC
cord-016187-58rqc0cg	111	10	:	:	:
cord-016187-58rqc0cg	112	1	common	common	JJ
cord-016187-58rqc0cg	112	2	;	;	:
cord-016187-58rqc0cg	112	3	+	+	CC
cord-016187-58rqc0cg	112	4	:	:	:
cord-016187-58rqc0cg	112	5	less	less	RBR
cord-016187-58rqc0cg	112	6	common	common	JJ
cord-016187-58rqc0cg	112	7	,	,	,
cord-016187-58rqc0cg	112	8	-	-	:
cord-016187-58rqc0cg	112	9	:	:	:
cord-016187-58rqc0cg	112	10	not	not	RB
cord-016187-58rqc0cg	112	11	reported	report	VBN
cord-016187-58rqc0cg	112	12	(	(	-LRB-
cord-016187-58rqc0cg	112	13	see	see	VB
cord-016187-58rqc0cg	112	14	reference	reference	NN
cord-016187-58rqc0cg	112	15	[	[	-LRB-
cord-016187-58rqc0cg	112	16	23	23	CD
cord-016187-58rqc0cg	112	17	]	]	-RRB-
cord-016187-58rqc0cg	112	18	)	)	-RRB-
cord-016187-58rqc0cg	113	1	Active	active	JJ
cord-016187-58rqc0cg	113	2	effl	effl	NNP
cord-016187-58rqc0cg	113	3	ux	ux	NNP
cord-016187-58rqc0cg	113	4	of	of	IN
cord-016187-58rqc0cg	113	5	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	113	6	agents	agent	NNS
cord-016187-58rqc0cg	113	7	is	be	VBZ
cord-016187-58rqc0cg	113	8	increasingly	increasingly	RB
cord-016187-58rqc0cg	113	9	utilized	utilize	VBN
cord-016187-58rqc0cg	113	10	by	by	IN
cord-016187-58rqc0cg	113	11	bacteria	bacteria	NNS
cord-016187-58rqc0cg	113	12	and	and	CC
cord-016187-58rqc0cg	113	13	fungi	fungus	NNS
cord-016187-58rqc0cg	113	14	as	as	IN
cord-016187-58rqc0cg	113	15	a	a	DT
cord-016187-58rqc0cg	113	16	mechanism	mechanism	NN
cord-016187-58rqc0cg	113	17	of	of	IN
cord-016187-58rqc0cg	113	18	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	113	19	resistance	resistance	NN
cord-016187-58rqc0cg	113	20	.	.	.
cord-016187-58rqc0cg	114	1	Some	some	DT
cord-016187-58rqc0cg	114	2	strains	strain	NNS
cord-016187-58rqc0cg	114	3	of	of	IN
cord-016187-58rqc0cg	114	4	E.	E.	NNP
cord-016187-58rqc0cg	114	5	coli	coli	NNS
cord-016187-58rqc0cg	114	6	,	,	,
cord-016187-58rqc0cg	114	7	Shigella	Shigella	NNP
cord-016187-58rqc0cg	114	8	,	,	,
cord-016187-58rqc0cg	114	9	and	and	CC
cord-016187-58rqc0cg	114	10	other	other	JJ
cord-016187-58rqc0cg	114	11	enteric	enteric	JJ
cord-016187-58rqc0cg	114	12	organisms	organism	NNS
cord-016187-58rqc0cg	114	13	express	express	VBP
cord-016187-58rqc0cg	114	14	a	a	DT
cord-016187-58rqc0cg	114	15	membrane	membrane	NN
cord-016187-58rqc0cg	114	16	transporter	transporter	NN
cord-016187-58rqc0cg	114	17	system	system	NN
cord-016187-58rqc0cg	114	18	that	that	WDT
cord-016187-58rqc0cg	114	19	leads	lead	VBZ
cord-016187-58rqc0cg	114	20	to	to	IN
cord-016187-58rqc0cg	114	21	multidrug	multidrug	NN
cord-016187-58rqc0cg	114	22	resistance	resistance	NN
cord-016187-58rqc0cg	114	23	by	by	IN
cord-016187-58rqc0cg	114	24	drug	drug	NN
cord-016187-58rqc0cg	114	25	effl	effl	NNP
cord-016187-58rqc0cg	114	26	ux	ux	NNP
cord-016187-58rqc0cg	114	27	[	[	-LRB-
cord-016187-58rqc0cg	114	28	35	35	CD
cord-016187-58rqc0cg	114	29	]	]	-RRB-
cord-016187-58rqc0cg	114	30	.	.	.
cord-016187-58rqc0cg	115	1	Specifi	Specifi	NNP
cord-016187-58rqc0cg	115	2	c	c	NNP
cord-016187-58rqc0cg	115	3	effl	effl	NNP
cord-016187-58rqc0cg	115	4	ux	ux	NNP
cord-016187-58rqc0cg	115	5	pumps	pump	NNS
cord-016187-58rqc0cg	115	6	also	also	RB
cord-016187-58rqc0cg	115	7	exist	exist	VBP
cord-016187-58rqc0cg	115	8	that	that	WDT
cord-016187-58rqc0cg	115	9	promote	promote	VBP
cord-016187-58rqc0cg	115	10	the	the	DT
cord-016187-58rqc0cg	115	11	egress	egress	NN
cord-016187-58rqc0cg	115	12	of	of	IN
cord-016187-58rqc0cg	115	13	single	single	JJ
cord-016187-58rqc0cg	115	14	classes	class	NNS
cord-016187-58rqc0cg	115	15	of	of	IN
cord-016187-58rqc0cg	115	16	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	115	17	agents	agent	NNS
cord-016187-58rqc0cg	115	18	.	.	.
cord-016187-58rqc0cg	116	1	Effl	Effl	NNP
cord-016187-58rqc0cg	116	2	ux	ux	NNP
cord-016187-58rqc0cg	116	3	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	116	4	are	be	VBP
cord-016187-58rqc0cg	116	5	the	the	DT
cord-016187-58rqc0cg	116	6	major	major	JJ
cord-016187-58rqc0cg	116	7	mechanism	mechanism	NN
cord-016187-58rqc0cg	116	8	of	of	IN
cord-016187-58rqc0cg	116	9	resistance	resistance	NN
cord-016187-58rqc0cg	116	10	to	to	IN
cord-016187-58rqc0cg	116	11	tetracyclines	tetracycline	NNS
cord-016187-58rqc0cg	116	12	in	in	IN
cord-016187-58rqc0cg	116	13	Gram	gram	NN
cord-016187-58rqc0cg	116	14	-	-	HYPH
cord-016187-58rqc0cg	116	15	negative	negative	JJ
cord-016187-58rqc0cg	116	16	bacteria	bacteria	NNS
cord-016187-58rqc0cg	116	17	.	.	.
cord-016187-58rqc0cg	117	1	Some	some	DT
cord-016187-58rqc0cg	117	2	strains	strain	NNS
cord-016187-58rqc0cg	117	3	of	of	IN
cord-016187-58rqc0cg	117	4	S.	S.	NNP
cord-016187-58rqc0cg	117	5	pneumoniae	pneumoniae	NN
cord-016187-58rqc0cg	117	6	,	,	,
cord-016187-58rqc0cg	117	7	S.	S.	NNP
cord-016187-58rqc0cg	117	8	pyogenes	pyogene	NNS
cord-016187-58rqc0cg	117	9	,	,	,
cord-016187-58rqc0cg	117	10	S.	S.	NNP
cord-016187-58rqc0cg	117	11	aureus	aureus	NN
cord-016187-58rqc0cg	117	12	,	,	,
cord-016187-58rqc0cg	117	13	and	and	CC
cord-016187-58rqc0cg	117	14	S.	S.	NNP
cord-016187-58rqc0cg	117	15	epidermidis	epidermidi	NNS
cord-016187-58rqc0cg	117	16	,	,	,
cord-016187-58rqc0cg	117	17	use	use	VBP
cord-016187-58rqc0cg	117	18	an	an	DT
cord-016187-58rqc0cg	117	19	active	active	JJ
cord-016187-58rqc0cg	117	20	effl	effl	NNP
cord-016187-58rqc0cg	117	21	ux	ux	NN
cord-016187-58rqc0cg	117	22	mechanism	mechanism	NN
cord-016187-58rqc0cg	117	23	to	to	TO
cord-016187-58rqc0cg	117	24	resist	resist	VB
cord-016187-58rqc0cg	117	25	macrolides	macrolide	NNS
cord-016187-58rqc0cg	117	26	,	,	,
cord-016187-58rqc0cg	117	27	streptogramins	streptogramin	NNS
cord-016187-58rqc0cg	117	28	,	,	,
cord-016187-58rqc0cg	117	29	and	and	CC
cord-016187-58rqc0cg	117	30	azalides	azalide	NNS
cord-016187-58rqc0cg	117	31	[	[	-LRB-
cord-016187-58rqc0cg	117	32	23	23	CD
cord-016187-58rqc0cg	117	33	]	]	-RRB-
cord-016187-58rqc0cg	117	34	.	.	.
cord-016187-58rqc0cg	118	1	This	this	DT
cord-016187-58rqc0cg	118	2	effl	effl	NN
cord-016187-58rqc0cg	118	3	ux	ux	NN
cord-016187-58rqc0cg	118	4	mechanism	mechanism	NN
cord-016187-58rqc0cg	118	5	is	be	VBZ
cord-016187-58rqc0cg	118	6	mediated	mediate	VBN
cord-016187-58rqc0cg	118	7	by	by	IN
cord-016187-58rqc0cg	118	8	the	the	DT
cord-016187-58rqc0cg	118	9	meF	meF	NNP
cord-016187-58rqc0cg	118	10	(	(	-LRB-
cord-016187-58rqc0cg	118	11	for	for	IN
cord-016187-58rqc0cg	118	12	macrolide	macrolide	NNP
cord-016187-58rqc0cg	118	13	effl	effl	NNP
cord-016187-58rqc0cg	118	14	ux	ux	NNP
cord-016187-58rqc0cg	118	15	)	)	-RRB-
cord-016187-58rqc0cg	118	16	genes	gene	NNS
cord-016187-58rqc0cg	118	17	in	in	IN
cord-016187-58rqc0cg	118	18	streptococci	streptococcus	NNS
cord-016187-58rqc0cg	118	19	and	and	CC
cord-016187-58rqc0cg	118	20	msr	msr	NNP
cord-016187-58rqc0cg	118	21	(	(	-LRB-
cord-016187-58rqc0cg	118	22	for	for	IN
cord-016187-58rqc0cg	118	23	macrolide	macrolide	NNP
cord-016187-58rqc0cg	118	24	streptogramin	streptogramin	NNP
cord-016187-58rqc0cg	118	25	resistance	resistance	NNP
cord-016187-58rqc0cg	118	26	)	)	-RRB-
cord-016187-58rqc0cg	118	27	genes	gene	NNS
cord-016187-58rqc0cg	118	28	in	in	IN
cord-016187-58rqc0cg	118	29	staphylococci	staphylococcus	NNS
cord-016187-58rqc0cg	118	30	.	.	.
cord-016187-58rqc0cg	119	1	A	a	DT
cord-016187-58rqc0cg	119	2	similar	similar	JJ
cord-016187-58rqc0cg	119	3	effl	effl	JJ
cord-016187-58rqc0cg	119	4	ux	ux	NNP
cord-016187-58rqc0cg	119	5	system	system	NN
cord-016187-58rqc0cg	119	6	,	,	,
cord-016187-58rqc0cg	119	7	encoded	encode	VBN
cord-016187-58rqc0cg	119	8	by	by	IN
cord-016187-58rqc0cg	119	9	a	a	DT
cord-016187-58rqc0cg	119	10	gene	gene	NN
cord-016187-58rqc0cg	119	11	referred	refer	VBN
cord-016187-58rqc0cg	119	12	to	to	IN
cord-016187-58rqc0cg	119	13	as	as	IN
cord-016187-58rqc0cg	119	14	mreA	mrea	JJ
cord-016187-58rqc0cg	119	15	(	(	-LRB-
cord-016187-58rqc0cg	119	16	for	for	IN
cord-016187-58rqc0cg	119	17	macrolide	macrolide	NNP
cord-016187-58rqc0cg	119	18	resistance	resistance	NNP
cord-016187-58rqc0cg	119	19	effl	effl	NNP
cord-016187-58rqc0cg	119	20	ux	ux	NNP
cord-016187-58rqc0cg	119	21	)	)	-RRB-
cord-016187-58rqc0cg	119	22	,	,	,
cord-016187-58rqc0cg	119	23	has	have	VBZ
cord-016187-58rqc0cg	119	24	been	be	VBN
cord-016187-58rqc0cg	119	25	described	describe	VBN
cord-016187-58rqc0cg	119	26	in	in	IN
cord-016187-58rqc0cg	119	27	group	group	NN
cord-016187-58rqc0cg	119	28	B	b	NN
cord-016187-58rqc0cg	119	29	streptococci	streptococcus	NNS
cord-016187-58rqc0cg	119	30	.	.	.
cord-016187-58rqc0cg	120	1	This	this	DT
cord-016187-58rqc0cg	120	2	mechanism	mechanism	NN
cord-016187-58rqc0cg	120	3	of	of	IN
cord-016187-58rqc0cg	120	4	resistance	resistance	NN
cord-016187-58rqc0cg	120	5	may	may	MD
cord-016187-58rqc0cg	120	6	be	be	VB
cord-016187-58rqc0cg	120	7	more	more	RBR
cord-016187-58rqc0cg	120	8	prevalent	prevalent	JJ
cord-016187-58rqc0cg	120	9	in	in	IN
cord-016187-58rqc0cg	120	10	community	community	NN
cord-016187-58rqc0cg	120	11	-	-	HYPH
cord-016187-58rqc0cg	120	12	acquired	acquire	VBN
cord-016187-58rqc0cg	120	13	infections	infection	NNS
cord-016187-58rqc0cg	120	14	than	than	IN
cord-016187-58rqc0cg	120	15	was	be	VBD
cord-016187-58rqc0cg	120	16	generally	generally	RB
cord-016187-58rqc0cg	120	17	appreciated	appreciate	VBN
cord-016187-58rqc0cg	120	18	.	.	.
cord-016187-58rqc0cg	121	1	Dissemination	dissemination	NN
cord-016187-58rqc0cg	121	2	of	of	IN
cord-016187-58rqc0cg	121	3	these	these	DT
cord-016187-58rqc0cg	121	4	resistance	resistance	NN
cord-016187-58rqc0cg	121	5	genes	gene	NNS
cord-016187-58rqc0cg	121	6	among	among	IN
cord-016187-58rqc0cg	121	7	important	important	JJ
cord-016187-58rqc0cg	121	8	bacterial	bacterial	JJ
cord-016187-58rqc0cg	121	9	pathogens	pathogen	NNS
cord-016187-58rqc0cg	121	10	constitutes	constitute	VBZ
cord-016187-58rqc0cg	121	11	a	a	DT
cord-016187-58rqc0cg	121	12	major	major	JJ
cord-016187-58rqc0cg	121	13	threat	threat	NN
cord-016187-58rqc0cg	121	14	to	to	IN
cord-016187-58rqc0cg	121	15	the	the	DT
cord-016187-58rqc0cg	121	16	continued	continued	JJ
cord-016187-58rqc0cg	121	17	usefulness	usefulness	NN
cord-016187-58rqc0cg	121	18	of	of	IN
cord-016187-58rqc0cg	121	19	macrolide	macrolide	JJ
cord-016187-58rqc0cg	121	20	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	121	21	[	[	-LRB-
cord-016187-58rqc0cg	121	22	36	36	CD
cord-016187-58rqc0cg	121	23	]	]	-RRB-
cord-016187-58rqc0cg	121	24	.	.	.
cord-016187-58rqc0cg	122	1	Active	active	JJ
cord-016187-58rqc0cg	122	2	effl	effl	NNP
cord-016187-58rqc0cg	122	3	ux	ux	NNP
cord-016187-58rqc0cg	122	4	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	122	5	may	may	MD
cord-016187-58rqc0cg	122	6	also	also	RB
cord-016187-58rqc0cg	122	7	contribute	contribute	VB
cord-016187-58rqc0cg	122	8	to	to	IN
cord-016187-58rqc0cg	122	9	the	the	DT
cord-016187-58rqc0cg	122	10	full	full	JJ
cord-016187-58rqc0cg	122	11	expression	expression	NN
cord-016187-58rqc0cg	122	12	of	of	IN
cord-016187-58rqc0cg	122	13	betalactam	betalactam	NNP
cord-016187-58rqc0cg	122	14	resistance	resistance	NN
cord-016187-58rqc0cg	122	15	in	in	IN
cord-016187-58rqc0cg	122	16	P.	P.	NNP
cord-016187-58rqc0cg	122	17	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	122	18	.	.	.
cord-016187-58rqc0cg	123	1	Multidrug	Multidrug	NNP
cord-016187-58rqc0cg	123	2	effl	effl	XX
cord-016187-58rqc0cg	124	1	ux	ux	NNP
cord-016187-58rqc0cg	124	2	pumps	pump	VBZ
cord-016187-58rqc0cg	124	3	in	in	IN
cord-016187-58rqc0cg	124	4	the	the	DT
cord-016187-58rqc0cg	124	5	inner	inner	JJ
cord-016187-58rqc0cg	124	6	and	and	CC
cord-016187-58rqc0cg	124	7	outer	outer	JJ
cord-016187-58rqc0cg	124	8	membrane	membrane	NN
cord-016187-58rqc0cg	124	9	of	of	IN
cord-016187-58rqc0cg	124	10	P.	P.	NNP
cord-016187-58rqc0cg	124	11	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	124	12	may	may	MD
cord-016187-58rqc0cg	124	13	combine	combine	VB
cord-016187-58rqc0cg	124	14	with	with	IN
cord-016187-58rqc0cg	124	15	periplasmic	periplasmic	JJ
cord-016187-58rqc0cg	124	16	beta	beta	NN
cord-016187-58rqc0cg	124	17	-	-	HYPH
cord-016187-58rqc0cg	124	18	lactamases	lactamase	NNS
cord-016187-58rqc0cg	124	19	and	and	CC
cord-016187-58rqc0cg	124	20	membrane	membrane	NN
cord-016187-58rqc0cg	124	21	permeability	permeability	NN
cord-016187-58rqc0cg	124	22	components	component	NNS
cord-016187-58rqc0cg	124	23	for	for	IN
cord-016187-58rqc0cg	124	24	full	full	JJ
cord-016187-58rqc0cg	124	25	expression	expression	NN
cord-016187-58rqc0cg	124	26	of	of	IN
cord-016187-58rqc0cg	124	27	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	124	28	resistance	resistance	NN
cord-016187-58rqc0cg	124	29	[	[	-LRB-
cord-016187-58rqc0cg	124	30	37	37	CD
cord-016187-58rqc0cg	124	31	]	]	-RRB-
cord-016187-58rqc0cg	124	32	.	.	.
cord-016187-58rqc0cg	125	1	Active	active	JJ
cord-016187-58rqc0cg	125	2	effl	effl	NNP
cord-016187-58rqc0cg	125	3	ux	ux	NNP
cord-016187-58rqc0cg	125	4	of	of	IN
cord-016187-58rqc0cg	125	5	fl	fl	NNP
cord-016187-58rqc0cg	125	6	uoroquinolones	uoroquinolone	NNS
cord-016187-58rqc0cg	125	7	by	by	IN
cord-016187-58rqc0cg	125	8	specifi	specifi	NNP
cord-016187-58rqc0cg	125	9	c	c	NNP
cord-016187-58rqc0cg	125	10	quinolone	quinolone	NNP
cord-016187-58rqc0cg	125	11	pumps	pump	NNS
cord-016187-58rqc0cg	125	12	or	or	CC
cord-016187-58rqc0cg	125	13	multidrug	multidrug	NN
cord-016187-58rqc0cg	125	14	transporter	transporter	NN
cord-016187-58rqc0cg	125	15	pumps	pump	NNS
cord-016187-58rqc0cg	125	16	has	have	VBZ
cord-016187-58rqc0cg	125	17	also	also	RB
cord-016187-58rqc0cg	125	18	been	be	VBN
cord-016187-58rqc0cg	125	19	detected	detect	VBN
cord-016187-58rqc0cg	125	20	in	in	IN
cord-016187-58rqc0cg	125	21	enteric	enteric	JJ
cord-016187-58rqc0cg	125	22	bacteria	bacteria	NNS
cord-016187-58rqc0cg	125	23	and	and	CC
cord-016187-58rqc0cg	125	24	staphylococci	staphylococcus	NNS
cord-016187-58rqc0cg	125	25	[	[	-LRB-
cord-016187-58rqc0cg	125	26	23	23	CD
cord-016187-58rqc0cg	125	27	]	]	-RRB-
cord-016187-58rqc0cg	125	28	.	.	.
cord-016187-58rqc0cg	126	1	Resistance	resistance	NN
cord-016187-58rqc0cg	126	2	to	to	IN
cord-016187-58rqc0cg	126	3	a	a	DT
cord-016187-58rqc0cg	126	4	wide	wide	JJ
cord-016187-58rqc0cg	126	5	variety	variety	NN
cord-016187-58rqc0cg	126	6	of	of	IN
cord-016187-58rqc0cg	126	7	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	126	8	agents	agent	NNS
cord-016187-58rqc0cg	126	9	,	,	,
cord-016187-58rqc0cg	126	10	including	include	VBG
cord-016187-58rqc0cg	126	11	tetracyclines	tetracycline	NNS
cord-016187-58rqc0cg	126	12	,	,	,
cord-016187-58rqc0cg	126	13	macrolides	macrolide	NNS
cord-016187-58rqc0cg	126	14	,	,	,
cord-016187-58rqc0cg	126	15	lincosamides	lincosamides	NNP
cord-016187-58rqc0cg	126	16	,	,	,
cord-016187-58rqc0cg	126	17	streptogramins	streptogramin	NNS
cord-016187-58rqc0cg	126	18	and	and	CC
cord-016187-58rqc0cg	126	19	the	the	DT
cord-016187-58rqc0cg	126	20	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	126	21	,	,	,
cord-016187-58rqc0cg	126	22	may	may	MD
cord-016187-58rqc0cg	126	23	result	result	VB
cord-016187-58rqc0cg	126	24	from	from	IN
cord-016187-58rqc0cg	126	25	alteration	alteration	NN
cord-016187-58rqc0cg	126	26	of	of	IN
cord-016187-58rqc0cg	126	27	ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	126	28	binding	binding	NN
cord-016187-58rqc0cg	126	29	sites	site	NNS
cord-016187-58rqc0cg	126	30	.	.	.
cord-016187-58rqc0cg	127	1	The	the	DT
cord-016187-58rqc0cg	127	2	MLS	MLS	NNP
cord-016187-58rqc0cg	127	3	B	B	NNP
cord-016187-58rqc0cg	127	4	-determinant	-determinant	NN
cord-016187-58rqc0cg	127	5	has	have	VBZ
cord-016187-58rqc0cg	127	6	the	the	DT
cord-016187-58rqc0cg	127	7	genes	gene	NNS
cord-016187-58rqc0cg	127	8	that	that	WDT
cord-016187-58rqc0cg	127	9	produce	produce	VBP
cord-016187-58rqc0cg	127	10	enzymes	enzyme	NNS
cord-016187-58rqc0cg	127	11	to	to	IN
cord-016187-58rqc0cg	127	12	dimethylate	dimethylate	VB
cord-016187-58rqc0cg	127	13	adenine	adenine	NN
cord-016187-58rqc0cg	127	14	residues	residue	NNS
cord-016187-58rqc0cg	127	15	on	on	IN
cord-016187-58rqc0cg	127	16	the	the	DT
cord-016187-58rqc0cg	127	17	23-S	23-s	CD
cord-016187-58rqc0cg	127	18	ribosomal	ribosomal	NNP
cord-016187-58rqc0cg	127	19	RNA	RNA	NNP
cord-016187-58rqc0cg	127	20	of	of	IN
cord-016187-58rqc0cg	127	21	the	the	DT
cord-016187-58rqc0cg	127	22	50-S	50-s	CD
cord-016187-58rqc0cg	127	23	subunit	subunit	NN
cord-016187-58rqc0cg	127	24	of	of	IN
cord-016187-58rqc0cg	127	25	the	the	DT
cord-016187-58rqc0cg	127	26	prokaryotic	prokaryotic	JJ
cord-016187-58rqc0cg	127	27	ribosome	ribosome	NN
cord-016187-58rqc0cg	127	28	,	,	,
cord-016187-58rqc0cg	127	29	disrupting	disrupt	VBG
cord-016187-58rqc0cg	127	30	the	the	DT
cord-016187-58rqc0cg	127	31	binding	binding	NN
cord-016187-58rqc0cg	127	32	of	of	IN
cord-016187-58rqc0cg	127	33	these	these	DT
cord-016187-58rqc0cg	127	34	drugs	drug	NNS
cord-016187-58rqc0cg	127	35	to	to	IN
cord-016187-58rqc0cg	127	36	the	the	DT
cord-016187-58rqc0cg	127	37	ribosome	ribosome	NN
cord-016187-58rqc0cg	127	38	.	.	.
cord-016187-58rqc0cg	128	1	Resistance	resistance	NN
cord-016187-58rqc0cg	128	2	to	to	IN
cord-016187-58rqc0cg	128	3	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	128	4	may	may	MD
cord-016187-58rqc0cg	128	5	also	also	RB
cord-016187-58rqc0cg	128	6	be	be	VB
cord-016187-58rqc0cg	128	7	mediated	mediate	VBN
cord-016187-58rqc0cg	128	8	at	at	IN
cord-016187-58rqc0cg	128	9	the	the	DT
cord-016187-58rqc0cg	128	10	ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	128	11	level	level	NN
cord-016187-58rqc0cg	128	12	.	.	.
cord-016187-58rqc0cg	129	1	Mutations	mutation	NNS
cord-016187-58rqc0cg	129	2	of	of	IN
cord-016187-58rqc0cg	129	3	the	the	DT
cord-016187-58rqc0cg	129	4	S12	S12	NNP
cord-016187-58rqc0cg	129	5	protein	protein	NN
cord-016187-58rqc0cg	129	6	of	of	IN
cord-016187-58rqc0cg	129	7	the	the	DT
cord-016187-58rqc0cg	129	8	30-S	30-s	CD
cord-016187-58rqc0cg	129	9	subunit	subunit	NN
cord-016187-58rqc0cg	129	10	have	have	VBP
cord-016187-58rqc0cg	129	11	been	be	VBN
cord-016187-58rqc0cg	129	12	shown	show	VBN
cord-016187-58rqc0cg	129	13	to	to	TO
cord-016187-58rqc0cg	129	14	interfere	interfere	VB
cord-016187-58rqc0cg	129	15	with	with	IN
cord-016187-58rqc0cg	129	16	binding	bind	VBG
cord-016187-58rqc0cg	129	17	streptomycin	streptomycin	NNS
cord-016187-58rqc0cg	129	18	to	to	IN
cord-016187-58rqc0cg	129	19	the	the	DT
cord-016187-58rqc0cg	129	20	ribosome	ribosome	NN
cord-016187-58rqc0cg	129	21	.	.	.
cord-016187-58rqc0cg	130	1	Ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	130	2	resistance	resistance	NN
cord-016187-58rqc0cg	130	3	to	to	IN
cord-016187-58rqc0cg	130	4	streptomycin	streptomycin	NNS
cord-016187-58rqc0cg	130	5	may	may	MD
cord-016187-58rqc0cg	130	6	be	be	VB
cord-016187-58rqc0cg	130	7	a	a	DT
cord-016187-58rqc0cg	130	8	signifi	signifi	NN
cord-016187-58rqc0cg	130	9	ca	can	MD
cord-016187-58rqc0cg	130	10	nt	not	RB
cord-016187-58rqc0cg	130	11	cause	cause	VB
cord-016187-58rqc0cg	130	12	of	of	IN
cord-016187-58rqc0cg	130	13	streptomycin	streptomycin	NNS
cord-016187-58rqc0cg	130	14	resistance	resistance	NN
cord-016187-58rqc0cg	130	15	among	among	IN
cord-016187-58rqc0cg	130	16	enterococcal	enterococcal	JJ
cord-016187-58rqc0cg	130	17	isolates	isolate	NNS
cord-016187-58rqc0cg	130	18	.	.	.
cord-016187-58rqc0cg	131	1	Ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	131	2	resistance	resistance	NN
cord-016187-58rqc0cg	131	3	to	to	IN
cord-016187-58rqc0cg	131	4	the	the	DT
cord-016187-58rqc0cg	131	5	2-deoxystreptamine	2-deoxystreptamine	CD
cord-016187-58rqc0cg	131	6	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	131	7	(	(	-LRB-
cord-016187-58rqc0cg	131	8	gentamicin	gentamicin	NNP
cord-016187-58rqc0cg	131	9	,	,	,
cord-016187-58rqc0cg	131	10	tobramycin	tobramycin	NNPS
cord-016187-58rqc0cg	131	11	,	,	,
cord-016187-58rqc0cg	131	12	amikacin	amikacin	NNP
cord-016187-58rqc0cg	131	13	)	)	-RRB-
cord-016187-58rqc0cg	131	14	appears	appear	VBZ
cord-016187-58rqc0cg	131	15	to	to	TO
cord-016187-58rqc0cg	131	16	be	be	VB
cord-016187-58rqc0cg	131	17	uncommon	uncommon	JJ
cord-016187-58rqc0cg	131	18	and	and	CC
cord-016187-58rqc0cg	131	19	may	may	MD
cord-016187-58rqc0cg	131	20	require	require	VB
cord-016187-58rqc0cg	131	21	multiple	multiple	JJ
cord-016187-58rqc0cg	131	22	mutations	mutation	NNS
cord-016187-58rqc0cg	131	23	in	in	IN
cord-016187-58rqc0cg	131	24	that	that	IN
cord-016187-58rqc0cg	131	25	these	these	DT
cord-016187-58rqc0cg	131	26	aminoglycosides	aminoglycoside	NNS
cord-016187-58rqc0cg	131	27	bind	bind	VBP
cord-016187-58rqc0cg	131	28	at	at	IN
cord-016187-58rqc0cg	131	29	several	several	JJ
cord-016187-58rqc0cg	131	30	sites	site	NNS
cord-016187-58rqc0cg	131	31	on	on	IN
cord-016187-58rqc0cg	131	32	both	both	CC
cord-016187-58rqc0cg	131	33	the	the	DT
cord-016187-58rqc0cg	131	34	30S	30s	CD
cord-016187-58rqc0cg	131	35	and	and	CC
cord-016187-58rqc0cg	131	36	50S	50s	CD
cord-016187-58rqc0cg	131	37	subunits	subunit	NNS
cord-016187-58rqc0cg	131	38	of	of	IN
cord-016187-58rqc0cg	131	39	the	the	DT
cord-016187-58rqc0cg	131	40	ribosome	ribosome	NN
cord-016187-58rqc0cg	131	41	[	[	-LRB-
cord-016187-58rqc0cg	131	42	23	23	CD
cord-016187-58rqc0cg	131	43	]	]	-RRB-
cord-016187-58rqc0cg	131	44	.	.	.
cord-016187-58rqc0cg	132	1	Vancomycin	Vancomycin	NNP
cord-016187-58rqc0cg	132	2	and	and	CC
cord-016187-58rqc0cg	132	3	other	other	JJ
cord-016187-58rqc0cg	132	4	glycopeptide	glycopeptide	NN
cord-016187-58rqc0cg	132	5	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	132	6	such	such	JJ
cord-016187-58rqc0cg	132	7	as	as	IN
cord-016187-58rqc0cg	132	8	teicoplanin	teicoplanin	NNS
cord-016187-58rqc0cg	132	9	bind	bind	VBP
cord-016187-58rqc0cg	132	10	to	to	IN
cord-016187-58rqc0cg	132	11	Dalanine	Dalanine	NNP
cord-016187-58rqc0cg	132	12	-	-	HYPH
cord-016187-58rqc0cg	132	13	D	D	NNP
cord-016187-58rqc0cg	132	14	-	-	HYPH
cord-016187-58rqc0cg	132	15	alanine	alanine	NN
cord-016187-58rqc0cg	132	16	,	,	,
cord-016187-58rqc0cg	132	17	which	which	WDT
cord-016187-58rqc0cg	132	18	is	be	VBZ
cord-016187-58rqc0cg	132	19	present	present	JJ
cord-016187-58rqc0cg	132	20	at	at	IN
cord-016187-58rqc0cg	132	21	the	the	DT
cord-016187-58rqc0cg	132	22	termini	terminus	NNS
cord-016187-58rqc0cg	132	23	of	of	IN
cord-016187-58rqc0cg	132	24	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	132	25	precursors	precursor	NNS
cord-016187-58rqc0cg	132	26	.	.	.
cord-016187-58rqc0cg	133	1	The	the	DT
cord-016187-58rqc0cg	133	2	large	large	JJ
cord-016187-58rqc0cg	133	3	glycopeptide	glycopeptide	NN
cord-016187-58rqc0cg	133	4	molecules	molecule	NNS
cord-016187-58rqc0cg	133	5	prevent	prevent	VBP
cord-016187-58rqc0cg	133	6	the	the	DT
cord-016187-58rqc0cg	133	7	incorporation	incorporation	NN
cord-016187-58rqc0cg	133	8	of	of	IN
cord-016187-58rqc0cg	133	9	the	the	DT
cord-016187-58rqc0cg	133	10	precursors	precursor	NNS
cord-016187-58rqc0cg	133	11	into	into	IN
cord-016187-58rqc0cg	133	12	the	the	DT
cord-016187-58rqc0cg	133	13	cell	cell	NN
cord-016187-58rqc0cg	133	14	wall	wall	NN
cord-016187-58rqc0cg	133	15	.	.	.
cord-016187-58rqc0cg	134	1	Resistance	resistance	NN
cord-016187-58rqc0cg	134	2	of	of	IN
cord-016187-58rqc0cg	134	3	enterococci	enterococci	NNS
cord-016187-58rqc0cg	134	4	to	to	IN
cord-016187-58rqc0cg	134	5	vancomycin	vancomycin	NNP
cord-016187-58rqc0cg	134	6	has	have	VBZ
cord-016187-58rqc0cg	134	7	been	be	VBN
cord-016187-58rqc0cg	134	8	classifi	classifi	NNP
cord-016187-58rqc0cg	134	9	ed	ed	NN
cord-016187-58rqc0cg	134	10	as	as	IN
cord-016187-58rqc0cg	134	11	A	A	NNP
cord-016187-58rqc0cg	134	12	-	-	HYPH
cord-016187-58rqc0cg	134	13	G	g	NN
cord-016187-58rqc0cg	134	14	based	base	VBN
cord-016187-58rqc0cg	134	15	upon	upon	IN
cord-016187-58rqc0cg	134	16	the	the	DT
cord-016187-58rqc0cg	134	17	genotype	genotype	NN
cord-016187-58rqc0cg	134	18	,	,	,
cord-016187-58rqc0cg	134	19	type	type	NN
cord-016187-58rqc0cg	134	20	of	of	IN
cord-016187-58rqc0cg	134	21	target	target	NN
cord-016187-58rqc0cg	134	22	site	site	NN
cord-016187-58rqc0cg	134	23	modifi	modifi	NNP
cord-016187-58rqc0cg	134	24	cation	cation	NN
cord-016187-58rqc0cg	134	25	and	and	CC
cord-016187-58rqc0cg	134	26	level	level	NN
cord-016187-58rqc0cg	134	27	of	of	IN
cord-016187-58rqc0cg	134	28	resistance	resistance	NN
cord-016187-58rqc0cg	134	29	to	to	IN
cord-016187-58rqc0cg	134	30	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	134	31	and	and	CC
cord-016187-58rqc0cg	134	32	teicoplanin	teicoplanin	NNP
cord-016187-58rqc0cg	134	33	[	[	-LRB-
cord-016187-58rqc0cg	134	34	38	38	CD
cord-016187-58rqc0cg	134	35	]	]	-RRB-
cord-016187-58rqc0cg	134	36	.	.	.
cord-016187-58rqc0cg	135	1	Strains	strain	NNS
cord-016187-58rqc0cg	135	2	of	of	IN
cord-016187-58rqc0cg	135	3	E.	E.	NNP
cord-016187-58rqc0cg	135	4	faecium	faecium	NNP
cord-016187-58rqc0cg	135	5	and	and	CC
cord-016187-58rqc0cg	135	6	E.	E.	NNP
cord-016187-58rqc0cg	135	7	faecalis	faecalis	NNP
cord-016187-58rqc0cg	135	8	with	with	IN
cord-016187-58rqc0cg	135	9	high	high	JJ
cord-016187-58rqc0cg	135	10	-	-	HYPH
cord-016187-58rqc0cg	135	11	level	level	NN
cord-016187-58rqc0cg	135	12	resistance	resistance	NN
cord-016187-58rqc0cg	135	13	to	to	IN
cord-016187-58rqc0cg	135	14	both	both	CC
cord-016187-58rqc0cg	135	15	vancomycin	vancomycin	NNS
cord-016187-58rqc0cg	135	16	and	and	CC
cord-016187-58rqc0cg	135	17	teicoplanin	teicoplanin	NNS
cord-016187-58rqc0cg	135	18	have	have	VBP
cord-016187-58rqc0cg	135	19	class	class	NN
cord-016187-58rqc0cg	135	20	A	a	DT
cord-016187-58rqc0cg	135	21	resistance	resistance	NN
cord-016187-58rqc0cg	135	22	.	.	.
cord-016187-58rqc0cg	136	1	Class	class	NN
cord-016187-58rqc0cg	136	2	A	a	DT
cord-016187-58rqc0cg	136	3	resistance	resistance	NN
cord-016187-58rqc0cg	136	4	is	be	VBZ
cord-016187-58rqc0cg	136	5	mediated	mediate	VBN
cord-016187-58rqc0cg	136	6	by	by	IN
cord-016187-58rqc0cg	136	7	the	the	DT
cord-016187-58rqc0cg	136	8	vanA	vanA	NNP
cord-016187-58rqc0cg	136	9	gene	gene	NN
cord-016187-58rqc0cg	136	10	cluster	cluster	NN
cord-016187-58rqc0cg	136	11	found	find	VBD
cord-016187-58rqc0cg	136	12	on	on	IN
cord-016187-58rqc0cg	136	13	an	an	DT
cord-016187-58rqc0cg	136	14	R	r	NN
cord-016187-58rqc0cg	136	15	plasmid	plasmid	NN
cord-016187-58rqc0cg	136	16	.	.	.
cord-016187-58rqc0cg	137	1	This	this	DT
cord-016187-58rqc0cg	137	2	protein	protein	NN
cord-016187-58rqc0cg	137	3	synthesizes	synthesize	VBZ
cord-016187-58rqc0cg	137	4	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	137	5	precursors	precursor	NNS
cord-016187-58rqc0cg	137	6	that	that	WDT
cord-016187-58rqc0cg	137	7	have	have	VBP
cord-016187-58rqc0cg	137	8	a	a	DT
cord-016187-58rqc0cg	137	9	depsipeptide	depsipeptide	NN
cord-016187-58rqc0cg	137	10	terminus	terminus	NN
cord-016187-58rqc0cg	137	11	(	(	-LRB-
cord-016187-58rqc0cg	137	12	D	d	JJ
cord-016187-58rqc0cg	137	13	-	-	HYPH
cord-016187-58rqc0cg	137	14	alanine	alanine	JJ
cord-016187-58rqc0cg	137	15	-	-	HYPH
cord-016187-58rqc0cg	137	16	D	d	NN
cord-016187-58rqc0cg	137	17	-	-	HYPH
cord-016187-58rqc0cg	137	18	lactate	lactate	NN
cord-016187-58rqc0cg	137	19	)	)	-RRB-
cord-016187-58rqc0cg	137	20	instead	instead	RB
cord-016187-58rqc0cg	137	21	of	of	IN
cord-016187-58rqc0cg	137	22	the	the	DT
cord-016187-58rqc0cg	137	23	usual	usual	JJ
cord-016187-58rqc0cg	137	24	D	d	NN
cord-016187-58rqc0cg	137	25	-	-	HYPH
cord-016187-58rqc0cg	137	26	alanine	alanine	JJ
cord-016187-58rqc0cg	137	27	-	-	HYPH
cord-016187-58rqc0cg	137	28	D	d	NN
cord-016187-58rqc0cg	137	29	-	-	HYPH
cord-016187-58rqc0cg	137	30	alanine	alanine	NN
cord-016187-58rqc0cg	137	31	.	.	.
cord-016187-58rqc0cg	138	1	The	the	DT
cord-016187-58rqc0cg	138	2	modified	modify	VBN
cord-016187-58rqc0cg	138	3	peptidoglycan	peptidoglycan	NN
cord-016187-58rqc0cg	138	4	binds	bind	VBZ
cord-016187-58rqc0cg	138	5	glycopeptide	glycopeptide	JJ
cord-016187-58rqc0cg	138	6	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	138	7	with	with	IN
cord-016187-58rqc0cg	138	8	reduced	reduce	VBN
cord-016187-58rqc0cg	138	9	affi	affi	NNP
cord-016187-58rqc0cg	138	10	nity	nity	NN
cord-016187-58rqc0cg	138	11	,	,	,
cord-016187-58rqc0cg	138	12	thus	thus	RB
cord-016187-58rqc0cg	138	13	conferring	confer	VBG
cord-016187-58rqc0cg	138	14	resistance	resistance	NN
cord-016187-58rqc0cg	138	15	to	to	IN
cord-016187-58rqc0cg	138	16	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	138	17	and	and	CC
cord-016187-58rqc0cg	138	18	teicoplanin	teicoplanin	NNS
cord-016187-58rqc0cg	138	19	.	.	.
cord-016187-58rqc0cg	139	1	The	the	DT
cord-016187-58rqc0cg	139	2	other	other	JJ
cord-016187-58rqc0cg	139	3	classes	class	NNS
cord-016187-58rqc0cg	139	4	of	of	IN
cord-016187-58rqc0cg	139	5	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	139	6	resistance	resistance	NN
cord-016187-58rqc0cg	139	7	genes	gene	NNS
cord-016187-58rqc0cg	139	8	vary	vary	VBP
cord-016187-58rqc0cg	139	9	in	in	IN
cord-016187-58rqc0cg	139	10	level	level	NN
cord-016187-58rqc0cg	139	11	of	of	IN
cord-016187-58rqc0cg	139	12	resistance	resistance	NN
cord-016187-58rqc0cg	139	13	,	,	,
cord-016187-58rqc0cg	139	14	species	species	NN
cord-016187-58rqc0cg	139	15	distribution	distribution	NN
cord-016187-58rqc0cg	139	16	and	and	CC
cord-016187-58rqc0cg	139	17	specifi	specifi	NN
cord-016187-58rqc0cg	139	18	c	c	NN
cord-016187-58rqc0cg	139	19	cell	cell	NN
cord-016187-58rqc0cg	139	20	wall	wall	NN
cord-016187-58rqc0cg	139	21	alterations	alteration	NNS
cord-016187-58rqc0cg	139	22	[	[	-LRB-
cord-016187-58rqc0cg	139	23	23	23	CD
cord-016187-58rqc0cg	139	24	,	,	,
cord-016187-58rqc0cg	139	25	38	38	CD
cord-016187-58rqc0cg	139	26	]	]	-RRB-
cord-016187-58rqc0cg	139	27	.	.	.
cord-016187-58rqc0cg	140	1	Vancomycin	vancomycin	NN
cord-016187-58rqc0cg	140	2	-	-	HYPH
cord-016187-58rqc0cg	140	3	intermediate	intermediate	JJ
cord-016187-58rqc0cg	140	4	strains	strain	NNS
cord-016187-58rqc0cg	140	5	of	of	IN
cord-016187-58rqc0cg	140	6	resistant	resistant	JJ
cord-016187-58rqc0cg	140	7	S.	S.	NNP
cord-016187-58rqc0cg	140	8	aureus	aureus	NN
cord-016187-58rqc0cg	140	9	(	(	-LRB-
cord-016187-58rqc0cg	140	10	VISA	VISA	NNP
cord-016187-58rqc0cg	140	11	)	)	-RRB-
cord-016187-58rqc0cg	140	12	have	have	VBP
cord-016187-58rqc0cg	140	13	been	be	VBN
cord-016187-58rqc0cg	140	14	isolated	isolate	VBN
cord-016187-58rqc0cg	140	15	with	with	IN
cord-016187-58rqc0cg	140	16	heterogeneous	heterogeneous	JJ
cord-016187-58rqc0cg	140	17	resistance	resistance	NN
cord-016187-58rqc0cg	140	18	patterns	pattern	NNS
cord-016187-58rqc0cg	140	19	.	.	.
cord-016187-58rqc0cg	141	1	VISA	VISA	NNP
cord-016187-58rqc0cg	141	2	strains	strain	NNS
cord-016187-58rqc0cg	141	3	express	express	VBP
cord-016187-58rqc0cg	141	4	unusually	unusually	RB
cord-016187-58rqc0cg	141	5	thick	thick	JJ
cord-016187-58rqc0cg	141	6	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	141	7	cell	cell	NN
cord-016187-58rqc0cg	141	8	walls	wall	NNS
cord-016187-58rqc0cg	141	9	that	that	WDT
cord-016187-58rqc0cg	141	10	are	be	VBP
cord-016187-58rqc0cg	141	11	less	less	RBR
cord-016187-58rqc0cg	141	12	completely	completely	RB
cord-016187-58rqc0cg	141	13	cross	cross	JJ
cord-016187-58rqc0cg	141	14	-	-	VBN
cord-016187-58rqc0cg	141	15	linked	link	VBN
cord-016187-58rqc0cg	141	16	together	together	RB
cord-016187-58rqc0cg	141	17	.	.	.
cord-016187-58rqc0cg	142	1	The	the	DT
cord-016187-58rqc0cg	142	2	cell	cell	NN
cord-016187-58rqc0cg	142	3	wall	wall	NN
cord-016187-58rqc0cg	142	4	in	in	IN
cord-016187-58rqc0cg	142	5	some	some	DT
cord-016187-58rqc0cg	142	6	strains	strain	NNS
cord-016187-58rqc0cg	142	7	of	of	IN
cord-016187-58rqc0cg	142	8	VISA	VISA	NNP
cord-016187-58rqc0cg	142	9	contains	contain	VBZ
cord-016187-58rqc0cg	142	10	non	non	JJ
cord-016187-58rqc0cg	142	11	-	-	JJ
cord-016187-58rqc0cg	142	12	amidated	amidated	JJ
cord-016187-58rqc0cg	142	13	glutamine	glutamine	NN
cord-016187-58rqc0cg	142	14	precursors	precursor	NNS
cord-016187-58rqc0cg	142	15	that	that	WDT
cord-016187-58rqc0cg	142	16	provide	provide	VBP
cord-016187-58rqc0cg	142	17	an	an	DT
cord-016187-58rqc0cg	142	18	increased	increase	VBN
cord-016187-58rqc0cg	142	19	number	number	NN
cord-016187-58rqc0cg	142	20	of	of	IN
cord-016187-58rqc0cg	142	21	false	false	JJ
cord-016187-58rqc0cg	142	22	binding	binding	NN
cord-016187-58rqc0cg	142	23	sites	site	NNS
cord-016187-58rqc0cg	142	24	to	to	IN
cord-016187-58rqc0cg	142	25	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	142	26	[	[	-LRB-
cord-016187-58rqc0cg	142	27	39	39	CD
cord-016187-58rqc0cg	142	28	]	]	-RRB-
cord-016187-58rqc0cg	142	29	.	.	.
cord-016187-58rqc0cg	143	1	The	the	DT
cord-016187-58rqc0cg	143	2	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	143	3	molecules	molecule	NNS
cord-016187-58rqc0cg	143	4	are	be	VBP
cord-016187-58rqc0cg	143	5	absorbed	absorb	VBN
cord-016187-58rqc0cg	143	6	to	to	IN
cord-016187-58rqc0cg	143	7	these	these	DT
cord-016187-58rqc0cg	143	8	excess	excess	JJ
cord-016187-58rqc0cg	143	9	binding	binding	NN
cord-016187-58rqc0cg	143	10	sites	site	NNS
cord-016187-58rqc0cg	143	11	thereby	thereby	RB
cord-016187-58rqc0cg	143	12	reducing	reduce	VBG
cord-016187-58rqc0cg	143	13	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	143	14	concentrations	concentration	NNS
cord-016187-58rqc0cg	143	15	at	at	IN
cord-016187-58rqc0cg	143	16	the	the	DT
cord-016187-58rqc0cg	143	17	growth	growth	NN
cord-016187-58rqc0cg	143	18	point	point	NN
cord-016187-58rqc0cg	143	19	of	of	IN
cord-016187-58rqc0cg	143	20	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	143	21	synthesis	synthesis	NN
cord-016187-58rqc0cg	143	22	along	along	IN
cord-016187-58rqc0cg	143	23	the	the	DT
cord-016187-58rqc0cg	143	24	inner	inner	JJ
cord-016187-58rqc0cg	143	25	surface	surface	NN
cord-016187-58rqc0cg	143	26	of	of	IN
cord-016187-58rqc0cg	143	27	the	the	DT
cord-016187-58rqc0cg	143	28	cell	cell	NN
cord-016187-58rqc0cg	143	29	wall	wall	NN
cord-016187-58rqc0cg	143	30	.	.	.
cord-016187-58rqc0cg	144	1	The	the	DT
cord-016187-58rqc0cg	144	2	arrival	arrival	NN
cord-016187-58rqc0cg	144	3	of	of	IN
cord-016187-58rqc0cg	144	4	high	high	JJ
cord-016187-58rqc0cg	144	5	level	level	NN
cord-016187-58rqc0cg	144	6	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	144	7	resistance	resistance	NN
cord-016187-58rqc0cg	144	8	from	from	IN
cord-016187-58rqc0cg	144	9	vanA	vanA	NNP
cord-016187-58rqc0cg	144	10	expressing	express	VBG
cord-016187-58rqc0cg	144	11	S.	S.	NNP
cord-016187-58rqc0cg	144	12	aureus	aureus	NN
cord-016187-58rqc0cg	144	13	[	[	-LRB-
cord-016187-58rqc0cg	144	14	17	17	CD
cord-016187-58rqc0cg	144	15	]	]	-RRB-
cord-016187-58rqc0cg	144	16	has	have	VBZ
cord-016187-58rqc0cg	144	17	created	create	VBN
cord-016187-58rqc0cg	144	18	a	a	DT
cord-016187-58rqc0cg	144	19	renewed	renew	VBN
cord-016187-58rqc0cg	144	20	sense	sense	NN
cord-016187-58rqc0cg	144	21	of	of	IN
cord-016187-58rqc0cg	144	22	urgency	urgency	NN
cord-016187-58rqc0cg	144	23	in	in	IN
cord-016187-58rqc0cg	144	24	the	the	DT
cord-016187-58rqc0cg	144	25	need	need	NN
cord-016187-58rqc0cg	144	26	to	to	TO
cord-016187-58rqc0cg	144	27	develop	develop	VB
cord-016187-58rqc0cg	144	28	novel	novel	JJ
cord-016187-58rqc0cg	144	29	strategies	strategy	NNS
cord-016187-58rqc0cg	144	30	to	to	TO
cord-016187-58rqc0cg	144	31	combat	combat	VB
cord-016187-58rqc0cg	144	32	multi	multi	JJ
cord-016187-58rqc0cg	144	33	-	-	JJ
cord-016187-58rqc0cg	144	34	drug	drug	JJ
cord-016187-58rqc0cg	144	35	resistant	resistant	JJ
cord-016187-58rqc0cg	144	36	bacterial	bacterial	JJ
cord-016187-58rqc0cg	144	37	pathogens	pathogen	NNS
cord-016187-58rqc0cg	144	38	.	.	.
cord-016187-58rqc0cg	145	1	Beta	beta	NN
cord-016187-58rqc0cg	145	2	-	-	HYPH
cord-016187-58rqc0cg	145	3	lactam	lactam	NN
cord-016187-58rqc0cg	145	4	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	145	5	inhibit	inhibit	VBP
cord-016187-58rqc0cg	145	6	bacteria	bacteria	NNS
cord-016187-58rqc0cg	145	7	by	by	IN
cord-016187-58rqc0cg	145	8	binding	bind	VBG
cord-016187-58rqc0cg	145	9	covalently	covalently	RB
cord-016187-58rqc0cg	145	10	to	to	IN
cord-016187-58rqc0cg	145	11	penicillinbinding	penicillinbinde	VBG
cord-016187-58rqc0cg	145	12	proteins	protein	NNS
cord-016187-58rqc0cg	145	13	(	(	-LRB-
cord-016187-58rqc0cg	145	14	PBPs	PBPs	NNP
cord-016187-58rqc0cg	145	15	)	)	-RRB-
cord-016187-58rqc0cg	145	16	in	in	IN
cord-016187-58rqc0cg	145	17	the	the	DT
cord-016187-58rqc0cg	145	18	cytoplasmic	cytoplasmic	JJ
cord-016187-58rqc0cg	145	19	membrane	membrane	NN
cord-016187-58rqc0cg	145	20	.	.	.
cord-016187-58rqc0cg	146	1	These	these	DT
cord-016187-58rqc0cg	146	2	target	target	NN
cord-016187-58rqc0cg	146	3	proteins	protein	NNS
cord-016187-58rqc0cg	146	4	catalyze	catalyze	VBP
cord-016187-58rqc0cg	146	5	the	the	DT
cord-016187-58rqc0cg	146	6	synthesis	synthesis	NN
cord-016187-58rqc0cg	146	7	of	of	IN
cord-016187-58rqc0cg	146	8	the	the	DT
cord-016187-58rqc0cg	146	9	peptidoglycan	peptidoglycan	NN
cord-016187-58rqc0cg	146	10	that	that	WDT
cord-016187-58rqc0cg	146	11	forms	form	VBZ
cord-016187-58rqc0cg	146	12	the	the	DT
cord-016187-58rqc0cg	146	13	cell	cell	NN
cord-016187-58rqc0cg	146	14	wall	wall	NN
cord-016187-58rqc0cg	146	15	of	of	IN
cord-016187-58rqc0cg	146	16	bacteria	bacteria	NNS
cord-016187-58rqc0cg	146	17	.	.	.
cord-016187-58rqc0cg	147	1	In	in	IN
cord-016187-58rqc0cg	147	2	Gram	gram	NN
cord-016187-58rqc0cg	147	3	-	-	HYPH
cord-016187-58rqc0cg	147	4	positive	positive	JJ
cord-016187-58rqc0cg	147	5	bacteria	bacteria	NNS
cord-016187-58rqc0cg	147	6	,	,	,
cord-016187-58rqc0cg	147	7	resistance	resistance	NN
cord-016187-58rqc0cg	147	8	to	to	IN
cord-016187-58rqc0cg	147	9	beta	beta	NN
cord-016187-58rqc0cg	147	10	-	-	HYPH
cord-016187-58rqc0cg	147	11	lactam	lactam	NN
cord-016187-58rqc0cg	147	12	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	147	13	may	may	MD
cord-016187-58rqc0cg	147	14	occur	occur	VB
cord-016187-58rqc0cg	147	15	by	by	IN
cord-016187-58rqc0cg	147	16	a	a	DT
cord-016187-58rqc0cg	147	17	decrease	decrease	NN
cord-016187-58rqc0cg	147	18	in	in	IN
cord-016187-58rqc0cg	147	19	the	the	DT
cord-016187-58rqc0cg	147	20	affi	affi	NNP
cord-016187-58rqc0cg	147	21	nity	nity	NN
cord-016187-58rqc0cg	147	22	of	of	IN
cord-016187-58rqc0cg	147	23	the	the	DT
cord-016187-58rqc0cg	147	24	PBP	PBP	NNP
cord-016187-58rqc0cg	147	25	for	for	IN
cord-016187-58rqc0cg	147	26	the	the	DT
cord-016187-58rqc0cg	147	27	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	147	28	or	or	CC
cord-016187-58rqc0cg	147	29	with	with	IN
cord-016187-58rqc0cg	147	30	a	a	DT
cord-016187-58rqc0cg	147	31	change	change	NN
cord-016187-58rqc0cg	147	32	in	in	IN
cord-016187-58rqc0cg	147	33	the	the	DT
cord-016187-58rqc0cg	147	34	amount	amount	NN
cord-016187-58rqc0cg	147	35	of	of	IN
cord-016187-58rqc0cg	147	36	PBP	PBP	NNP
cord-016187-58rqc0cg	147	37	produced	produce	VBN
cord-016187-58rqc0cg	147	38	by	by	IN
cord-016187-58rqc0cg	147	39	the	the	DT
cord-016187-58rqc0cg	147	40	bacterium	bacterium	NN
cord-016187-58rqc0cg	147	41	[	[	-LRB-
cord-016187-58rqc0cg	147	42	23	23	CD
cord-016187-58rqc0cg	147	43	]	]	-RRB-
cord-016187-58rqc0cg	147	44	.	.	.
cord-016187-58rqc0cg	148	1	These	these	DT
cord-016187-58rqc0cg	148	2	low	low	JJ
cord-016187-58rqc0cg	148	3	affi	affi	NNP
cord-016187-58rqc0cg	148	4	nity	nity	NN
cord-016187-58rqc0cg	148	5	binding	bind	VBG
cord-016187-58rqc0cg	148	6	PBPs	pbp	NNS
cord-016187-58rqc0cg	148	7	may	may	MD
cord-016187-58rqc0cg	148	8	be	be	VB
cord-016187-58rqc0cg	148	9	inducible	inducible	JJ
cord-016187-58rqc0cg	148	10	where	where	WRB
cord-016187-58rqc0cg	148	11	their	-PRON-	PRP$
cord-016187-58rqc0cg	148	12	production	production	NN
cord-016187-58rqc0cg	148	13	is	be	VBZ
cord-016187-58rqc0cg	148	14	stimulated	stimulate	VBN
cord-016187-58rqc0cg	148	15	by	by	IN
cord-016187-58rqc0cg	148	16	exposure	exposure	NN
cord-016187-58rqc0cg	148	17	of	of	IN
cord-016187-58rqc0cg	148	18	the	the	DT
cord-016187-58rqc0cg	148	19	microorganism	microorganism	NN
cord-016187-58rqc0cg	148	20	to	to	IN
cord-016187-58rqc0cg	148	21	the	the	DT
cord-016187-58rqc0cg	148	22	beta	beta	NN
cord-016187-58rqc0cg	148	23	-	-	HYPH
cord-016187-58rqc0cg	148	24	lactam	lactam	NNS
cord-016187-58rqc0cg	148	25	drug	drug	NN
cord-016187-58rqc0cg	148	26	[	[	-LRB-
cord-016187-58rqc0cg	148	27	40	40	CD
cord-016187-58rqc0cg	148	28	]	]	-RRB-
cord-016187-58rqc0cg	148	29	.	.	.
cord-016187-58rqc0cg	149	1	The	the	DT
cord-016187-58rqc0cg	149	2	structural	structural	JJ
cord-016187-58rqc0cg	149	3	gene	gene	NN
cord-016187-58rqc0cg	149	4	(	(	-LRB-
cord-016187-58rqc0cg	149	5	mecA	mecA	NNP
cord-016187-58rqc0cg	149	6	)	)	-RRB-
cord-016187-58rqc0cg	149	7	that	that	WDT
cord-016187-58rqc0cg	149	8	determines	determine	VBZ
cord-016187-58rqc0cg	149	9	the	the	DT
cord-016187-58rqc0cg	149	10	low	low	RB
cord-016187-58rqc0cg	149	11	-	-	HYPH
cord-016187-58rqc0cg	149	12	affi	affi	VBN
cord-016187-58rqc0cg	149	13	nity	nity	NN
cord-016187-58rqc0cg	149	14	PBP	PBP	NNP
cord-016187-58rqc0cg	149	15	of	of	IN
cord-016187-58rqc0cg	149	16	MRSA	MRSA	NNP
cord-016187-58rqc0cg	149	17	shares	share	NNS
cord-016187-58rqc0cg	149	18	extensive	extensive	JJ
cord-016187-58rqc0cg	149	19	sequence	sequence	NN
cord-016187-58rqc0cg	149	20	homology	homology	NN
cord-016187-58rqc0cg	149	21	with	with	IN
cord-016187-58rqc0cg	149	22	a	a	DT
cord-016187-58rqc0cg	149	23	PBP	PBP	NNP
cord-016187-58rqc0cg	149	24	of	of	IN
cord-016187-58rqc0cg	149	25	E.	E.	NNP
cord-016187-58rqc0cg	149	26	coli	coli	NNS
cord-016187-58rqc0cg	149	27	,	,	,
cord-016187-58rqc0cg	149	28	and	and	CC
cord-016187-58rqc0cg	149	29	the	the	DT
cord-016187-58rqc0cg	149	30	genes	gene	NNS
cord-016187-58rqc0cg	149	31	that	that	WDT
cord-016187-58rqc0cg	149	32	regulate	regulate	VBP
cord-016187-58rqc0cg	149	33	the	the	DT
cord-016187-58rqc0cg	149	34	production	production	NN
cord-016187-58rqc0cg	149	35	of	of	IN
cord-016187-58rqc0cg	149	36	the	the	DT
cord-016187-58rqc0cg	149	37	low	low	RB
cord-016187-58rqc0cg	149	38	-	-	HYPH
cord-016187-58rqc0cg	149	39	affi	affi	VBN
cord-016187-58rqc0cg	149	40	nity	nity	NN
cord-016187-58rqc0cg	149	41	PBP	PBP	NNP
cord-016187-58rqc0cg	149	42	have	have	VBP
cord-016187-58rqc0cg	149	43	considerable	considerable	JJ
cord-016187-58rqc0cg	149	44	sequence	sequence	NN
cord-016187-58rqc0cg	149	45	homology	homology	NN
cord-016187-58rqc0cg	149	46	with	with	IN
cord-016187-58rqc0cg	149	47	the	the	DT
cord-016187-58rqc0cg	149	48	genes	gene	NNS
cord-016187-58rqc0cg	149	49	that	that	WDT
cord-016187-58rqc0cg	149	50	regulate	regulate	VBP
cord-016187-58rqc0cg	149	51	the	the	DT
cord-016187-58rqc0cg	149	52	production	production	NN
cord-016187-58rqc0cg	149	53	of	of	IN
cord-016187-58rqc0cg	149	54	staphylococcal	staphylococcal	JJ
cord-016187-58rqc0cg	149	55	penicillinase	penicillinase	NN
cord-016187-58rqc0cg	149	56	[	[	-LRB-
cord-016187-58rqc0cg	149	57	23	23	CD
cord-016187-58rqc0cg	149	58	]	]	-RRB-
cord-016187-58rqc0cg	149	59	.	.	.
cord-016187-58rqc0cg	150	1	The	the	DT
cord-016187-58rqc0cg	150	2	PBPs	pbp	NNS
cord-016187-58rqc0cg	150	3	of	of	IN
cord-016187-58rqc0cg	150	4	beta	beta	NN
cord-016187-58rqc0cg	150	5	-	-	HYPH
cord-016187-58rqc0cg	150	6	lactamase	lactamase	JJ
cord-016187-58rqc0cg	150	7	-	-	HYPH
cord-016187-58rqc0cg	150	8	negative	negative	JJ
cord-016187-58rqc0cg	150	9	penicillin	penicillin	NN
cord-016187-58rqc0cg	150	10	-	-	HYPH
cord-016187-58rqc0cg	150	11	resistant	resistant	JJ
cord-016187-58rqc0cg	150	12	strains	strain	NNS
cord-016187-58rqc0cg	150	13	of	of	IN
cord-016187-58rqc0cg	150	14	N.	N.	NNP
cord-016187-58rqc0cg	150	15	gonorrhoeae	gonorrhoeae	NNP
cord-016187-58rqc0cg	150	16	,	,	,
cord-016187-58rqc0cg	150	17	N.	N.	NNP
cord-016187-58rqc0cg	150	18	meningitidis	meningitidis	NNP
cord-016187-58rqc0cg	150	19	,	,	,
cord-016187-58rqc0cg	150	20	and	and	CC
cord-016187-58rqc0cg	150	21	Haemophilus	haemophilus	JJ
cord-016187-58rqc0cg	150	22	infl	infl	NN
cord-016187-58rqc0cg	150	23	uenzae	uenzae	NNS
cord-016187-58rqc0cg	150	24	have	have	VBP
cord-016187-58rqc0cg	150	25	shown	show	VBN
cord-016187-58rqc0cg	150	26	reduced	reduce	VBN
cord-016187-58rqc0cg	150	27	penicillin	penicillin	NN
cord-016187-58rqc0cg	150	28	-	-	HYPH
cord-016187-58rqc0cg	150	29	binding	bind	VBG
cord-016187-58rqc0cg	150	30	affi	affi	FW
cord-016187-58rqc0cg	150	31	nity	nity	NN
cord-016187-58rqc0cg	150	32	[	[	-LRB-
cord-016187-58rqc0cg	150	33	41	41	CD
cord-016187-58rqc0cg	150	34	]	]	-RRB-
cord-016187-58rqc0cg	150	35	.	.	.
cord-016187-58rqc0cg	151	1	Their	-PRON-	PRP$
cord-016187-58rqc0cg	151	2	PBPs	pbp	NNS
cord-016187-58rqc0cg	151	3	appear	appear	VBP
cord-016187-58rqc0cg	151	4	to	to	TO
cord-016187-58rqc0cg	151	5	be	be	VB
cord-016187-58rqc0cg	151	6	encoded	encode	VBN
cord-016187-58rqc0cg	151	7	by	by	IN
cord-016187-58rqc0cg	151	8	hybrid	hybrid	JJ
cord-016187-58rqc0cg	151	9	genes	gene	NNS
cord-016187-58rqc0cg	151	10	containing	contain	VBG
cord-016187-58rqc0cg	151	11	segments	segment	NNS
cord-016187-58rqc0cg	151	12	of	of	IN
cord-016187-58rqc0cg	151	13	DNA	dna	NN
cord-016187-58rqc0cg	151	14	scavenged	scavenge	VBN
cord-016187-58rqc0cg	151	15	from	from	IN
cord-016187-58rqc0cg	151	16	resistant	resistant	JJ
cord-016187-58rqc0cg	151	17	strains	strain	NNS
cord-016187-58rqc0cg	151	18	of	of	IN
cord-016187-58rqc0cg	151	19	related	relate	VBN
cord-016187-58rqc0cg	151	20	species	specie	NNS
cord-016187-58rqc0cg	151	21	,	,	,
cord-016187-58rqc0cg	151	22	similar	similar	JJ
cord-016187-58rqc0cg	151	23	to	to	IN
cord-016187-58rqc0cg	151	24	penicillin	penicillin	NN
cord-016187-58rqc0cg	151	25	-	-	HYPH
cord-016187-58rqc0cg	151	26	resistant	resistant	JJ
cord-016187-58rqc0cg	151	27	pneumococci	pneumococcus	NNS
cord-016187-58rqc0cg	151	28	[	[	-LRB-
cord-016187-58rqc0cg	151	29	23	23	CD
cord-016187-58rqc0cg	151	30	]	]	-RRB-
cord-016187-58rqc0cg	151	31	.	.	.
cord-016187-58rqc0cg	152	1	DNA	DNA	NNP
cord-016187-58rqc0cg	152	2	gyrase	gyrase	NNP
cord-016187-58rqc0cg	152	3	(	(	-LRB-
cord-016187-58rqc0cg	152	4	also	also	RB
cord-016187-58rqc0cg	152	5	known	know	VBN
cord-016187-58rqc0cg	152	6	as	as	IN
cord-016187-58rqc0cg	152	7	bacterial	bacterial	JJ
cord-016187-58rqc0cg	152	8	topoisomerase	topoisomerase	NN
cord-016187-58rqc0cg	152	9	II	II	NNP
cord-016187-58rqc0cg	152	10	)	)	-RRB-
cord-016187-58rqc0cg	152	11	is	be	VBZ
cord-016187-58rqc0cg	152	12	necessary	necessary	JJ
cord-016187-58rqc0cg	152	13	for	for	IN
cord-016187-58rqc0cg	152	14	the	the	DT
cord-016187-58rqc0cg	152	15	supercoiling	supercoiling	NN
cord-016187-58rqc0cg	152	16	of	of	IN
cord-016187-58rqc0cg	152	17	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	152	18	DNA	dna	NN
cord-016187-58rqc0cg	152	19	in	in	IN
cord-016187-58rqc0cg	152	20	bacteria	bacteria	NNS
cord-016187-58rqc0cg	152	21	in	in	IN
cord-016187-58rqc0cg	152	22	order	order	NN
cord-016187-58rqc0cg	152	23	to	to	TO
cord-016187-58rqc0cg	152	24	have	have	VB
cord-016187-58rqc0cg	152	25	effi	effi	NNP
cord-016187-58rqc0cg	152	26	cient	cient	NNP
cord-016187-58rqc0cg	152	27	cell	cell	NN
cord-016187-58rqc0cg	152	28	division	division	NN
cord-016187-58rqc0cg	152	29	[	[	-LRB-
cord-016187-58rqc0cg	152	30	23	23	CD
cord-016187-58rqc0cg	152	31	]	]	-RRB-
cord-016187-58rqc0cg	152	32	.	.	.
cord-016187-58rqc0cg	153	1	Another	another	DT
cord-016187-58rqc0cg	153	2	related	related	JJ
cord-016187-58rqc0cg	153	3	enzyme	enzyme	NN
cord-016187-58rqc0cg	153	4	,	,	,
cord-016187-58rqc0cg	153	5	topoisomerase	topoisomerase	NN
cord-016187-58rqc0cg	153	6	IV	IV	NNP
cord-016187-58rqc0cg	153	7	is	be	VBZ
cord-016187-58rqc0cg	153	8	also	also	RB
cord-016187-58rqc0cg	153	9	required	require	VBN
cord-016187-58rqc0cg	153	10	for	for	IN
cord-016187-58rqc0cg	153	11	segregation	segregation	NN
cord-016187-58rqc0cg	153	12	of	of	IN
cord-016187-58rqc0cg	153	13	bacterial	bacterial	JJ
cord-016187-58rqc0cg	153	14	genomes	genome	NNS
cord-016187-58rqc0cg	153	15	into	into	IN
cord-016187-58rqc0cg	153	16	two	two	CD
cord-016187-58rqc0cg	153	17	daughter	daughter	NN
cord-016187-58rqc0cg	153	18	cells	cell	NNS
cord-016187-58rqc0cg	153	19	during	during	IN
cord-016187-58rqc0cg	153	20	cell	cell	NN
cord-016187-58rqc0cg	153	21	division	division	NN
cord-016187-58rqc0cg	153	22	.	.	.
cord-016187-58rqc0cg	154	1	These	these	DT
cord-016187-58rqc0cg	154	2	enzymes	enzyme	NNS
cord-016187-58rqc0cg	154	3	consist	consist	VBP
cord-016187-58rqc0cg	154	4	of	of	IN
cord-016187-58rqc0cg	154	5	two	two	CD
cord-016187-58rqc0cg	154	6	A	a	DT
cord-016187-58rqc0cg	154	7	subunits	subunit	NNS
cord-016187-58rqc0cg	154	8	encoded	encode	VBN
cord-016187-58rqc0cg	154	9	by	by	IN
cord-016187-58rqc0cg	154	10	the	the	DT
cord-016187-58rqc0cg	154	11	gyrA	gyra	CD
cord-016187-58rqc0cg	154	12	gene	gene	NN
cord-016187-58rqc0cg	154	13	and	and	CC
cord-016187-58rqc0cg	154	14	two	two	CD
cord-016187-58rqc0cg	154	15	B	b	NN
cord-016187-58rqc0cg	154	16	subunits	subunit	NNS
cord-016187-58rqc0cg	154	17	encoded	encode	VBN
cord-016187-58rqc0cg	154	18	by	by	IN
cord-016187-58rqc0cg	154	19	the	the	DT
cord-016187-58rqc0cg	154	20	gyrB	gyrb	CD
cord-016187-58rqc0cg	154	21	gene	gene	NN
cord-016187-58rqc0cg	154	22	(	(	-LRB-
cord-016187-58rqc0cg	154	23	or	or	CC
cord-016187-58rqc0cg	154	24	parC	parc	JJ
cord-016187-58rqc0cg	154	25	and	and	CC
cord-016187-58rqc0cg	154	26	parE	parE	NNP
cord-016187-58rqc0cg	154	27	for	for	IN
cord-016187-58rqc0cg	154	28	topoisomerase	topoisomerase	NN
cord-016187-58rqc0cg	154	29	IV	IV	NNP
cord-016187-58rqc0cg	154	30	.	.	.
cord-016187-58rqc0cg	155	1	Although	although	IN
cord-016187-58rqc0cg	155	2	spontaneous	spontaneous	JJ
cord-016187-58rqc0cg	155	3	mutation	mutation	NN
cord-016187-58rqc0cg	155	4	ot	ot	VBP
cord-016187-58rqc0cg	155	5	the	the	DT
cord-016187-58rqc0cg	155	6	A	a	NN
cord-016187-58rqc0cg	155	7	-	-	HYPH
cord-016187-58rqc0cg	155	8	subunit	subunit	NN
cord-016187-58rqc0cg	155	9	of	of	IN
cord-016187-58rqc0cg	155	10	the	the	DT
cord-016187-58rqc0cg	155	11	gyrA	gyra	CD
cord-016187-58rqc0cg	155	12	locus	locus	NN
cord-016187-58rqc0cg	155	13	is	be	VBZ
cord-016187-58rqc0cg	155	14	the	the	DT
cord-016187-58rqc0cg	155	15	most	most	RBS
cord-016187-58rqc0cg	155	16	common	common	JJ
cord-016187-58rqc0cg	155	17	cause	cause	NN
cord-016187-58rqc0cg	155	18	of	of	IN
cord-016187-58rqc0cg	155	19	resistance	resistance	NN
cord-016187-58rqc0cg	155	20	to	to	IN
cord-016187-58rqc0cg	155	21	multiple	multiple	JJ
cord-016187-58rqc0cg	155	22	fl	fl	NNP
cord-016187-58rqc0cg	155	23	uoroquinolones	uoroquinolone	NNS
cord-016187-58rqc0cg	155	24	in	in	IN
cord-016187-58rqc0cg	155	25	enteric	enteric	JJ
cord-016187-58rqc0cg	155	26	bacteria	bacteria	NNS
cord-016187-58rqc0cg	155	27	,	,	,
cord-016187-58rqc0cg	155	28	B	b	NN
cord-016187-58rqc0cg	155	29	-	-	HYPH
cord-016187-58rqc0cg	155	30	subunit	subunit	NN
cord-016187-58rqc0cg	155	31	alterations	alteration	NNS
cord-016187-58rqc0cg	155	32	may	may	MD
cord-016187-58rqc0cg	155	33	also	also	RB
cord-016187-58rqc0cg	155	34	affect	affect	VB
cord-016187-58rqc0cg	155	35	resistance	resistance	NN
cord-016187-58rqc0cg	155	36	to	to	IN
cord-016187-58rqc0cg	155	37	these	these	DT
cord-016187-58rqc0cg	155	38	drugs	drug	NNS
cord-016187-58rqc0cg	155	39	.	.	.
cord-016187-58rqc0cg	156	1	DNA	DNA	NNP
cord-016187-58rqc0cg	156	2	gyrase	gyrase	NNP
cord-016187-58rqc0cg	156	3	(	(	-LRB-
cord-016187-58rqc0cg	156	4	topoisomerase	topoisomerase	NNP
cord-016187-58rqc0cg	156	5	II	II	NNP
cord-016187-58rqc0cg	156	6	)	)	-RRB-
cord-016187-58rqc0cg	156	7	is	be	VBZ
cord-016187-58rqc0cg	156	8	the	the	DT
cord-016187-58rqc0cg	156	9	primary	primary	JJ
cord-016187-58rqc0cg	156	10	site	site	NN
cord-016187-58rqc0cg	156	11	of	of	IN
cord-016187-58rqc0cg	156	12	action	action	NN
cord-016187-58rqc0cg	156	13	in	in	IN
cord-016187-58rqc0cg	156	14	Gram	gram	NN
cord-016187-58rqc0cg	156	15	-	-	HYPH
cord-016187-58rqc0cg	156	16	negative	negative	JJ
cord-016187-58rqc0cg	156	17	bacteria	bacteria	NNS
cord-016187-58rqc0cg	156	18	whereas	whereas	IN
cord-016187-58rqc0cg	156	19	topoisomerase	topoisomerase	NN
cord-016187-58rqc0cg	156	20	IV	IV	NNP
cord-016187-58rqc0cg	156	21	is	be	VBZ
cord-016187-58rqc0cg	156	22	the	the	DT
cord-016187-58rqc0cg	156	23	principal	principal	JJ
cord-016187-58rqc0cg	156	24	target	target	NN
cord-016187-58rqc0cg	156	25	of	of	IN
cord-016187-58rqc0cg	156	26	quinolones	quinolone	NNS
cord-016187-58rqc0cg	156	27	in	in	IN
cord-016187-58rqc0cg	156	28	Gram	gram	NN
cord-016187-58rqc0cg	156	29	-	-	HYPH
cord-016187-58rqc0cg	156	30	positive	positive	JJ
cord-016187-58rqc0cg	156	31	bacteria	bacteria	NNS
cord-016187-58rqc0cg	156	32	.	.	.
cord-016187-58rqc0cg	157	1	Mutations	mutation	NNS
cord-016187-58rqc0cg	157	2	in	in	IN
cord-016187-58rqc0cg	157	3	a	a	DT
cord-016187-58rqc0cg	157	4	variety	variety	NN
cord-016187-58rqc0cg	157	5	of	of	IN
cord-016187-58rqc0cg	157	6	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	157	7	loci	locus	NNS
cord-016187-58rqc0cg	157	8	have	have	VBP
cord-016187-58rqc0cg	157	9	been	be	VBN
cord-016187-58rqc0cg	157	10	described	describe	VBN
cord-016187-58rqc0cg	157	11	that	that	IN
cord-016187-58rqc0cg	157	12	resulted	result	VBD
cord-016187-58rqc0cg	157	13	in	in	IN
cord-016187-58rqc0cg	157	14	altered	alter	VBN
cord-016187-58rqc0cg	157	15	DNA	dna	NN
cord-016187-58rqc0cg	157	16	gyrases	gyrase	NNS
cord-016187-58rqc0cg	157	17	resistant	resistant	JJ
cord-016187-58rqc0cg	157	18	to	to	IN
cord-016187-58rqc0cg	157	19	nalidixic	nalidixic	NNP
cord-016187-58rqc0cg	157	20	acid	acid	NNP
cord-016187-58rqc0cg	157	21	and	and	CC
cord-016187-58rqc0cg	157	22	the	the	DT
cord-016187-58rqc0cg	157	23	newer	new	JJR
cord-016187-58rqc0cg	157	24	fl	fl	NNP
cord-016187-58rqc0cg	157	25	uoroquinolones	uoroquinolone	NNS
cord-016187-58rqc0cg	157	26	in	in	IN
cord-016187-58rqc0cg	157	27	Enterobacteriaceae	Enterobacteriaceae	NNP
cord-016187-58rqc0cg	157	28	and	and	CC
cord-016187-58rqc0cg	157	29	P.	P.	NNP
cord-016187-58rqc0cg	157	30	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	157	31	.	.	.
cord-016187-58rqc0cg	158	1	Many	many	JJ
cord-016187-58rqc0cg	158	2	of	of	IN
cord-016187-58rqc0cg	158	3	these	these	DT
cord-016187-58rqc0cg	158	4	mutations	mutation	NNS
cord-016187-58rqc0cg	158	5	involve	involve	VBP
cord-016187-58rqc0cg	158	6	the	the	DT
cord-016187-58rqc0cg	158	7	substitution	substitution	NN
cord-016187-58rqc0cg	158	8	of	of	IN
cord-016187-58rqc0cg	158	9	single	single	JJ
cord-016187-58rqc0cg	158	10	amino	amino	NN
cord-016187-58rqc0cg	158	11	acids	acid	NNS
cord-016187-58rqc0cg	158	12	at	at	IN
cord-016187-58rqc0cg	158	13	key	key	JJ
cord-016187-58rqc0cg	158	14	enzymatic	enzymatic	JJ
cord-016187-58rqc0cg	158	15	sites	site	NNS
cord-016187-58rqc0cg	158	16	(	(	-LRB-
cord-016187-58rqc0cg	158	17	located	locate	VBN
cord-016187-58rqc0cg	158	18	between	between	IN
cord-016187-58rqc0cg	158	19	amino	amino	JJ
cord-016187-58rqc0cg	158	20	acids	acid	NNS
cord-016187-58rqc0cg	158	21	67	67	CD
cord-016187-58rqc0cg	158	22	-	-	SYM
cord-016187-58rqc0cg	158	23	106	106	CD
cord-016187-58rqc0cg	158	24	in	in	IN
cord-016187-58rqc0cg	158	25	the	the	DT
cord-016187-58rqc0cg	158	26	gyrase	gyrase	NN
cord-016187-58rqc0cg	158	27	A	a	DT
cord-016187-58rqc0cg	158	28	subunit	subunit	NN
cord-016187-58rqc0cg	158	29	)	)	-RRB-
cord-016187-58rqc0cg	158	30	that	that	WDT
cord-016187-58rqc0cg	158	31	are	be	VBP
cord-016187-58rqc0cg	158	32	involved	involve	VBN
cord-016187-58rqc0cg	158	33	in	in	IN
cord-016187-58rqc0cg	158	34	the	the	DT
cord-016187-58rqc0cg	158	35	generation	generation	NN
cord-016187-58rqc0cg	158	36	of	of	IN
cord-016187-58rqc0cg	158	37	the	the	DT
cord-016187-58rqc0cg	158	38	DNA	dna	NN
cord-016187-58rqc0cg	158	39	gyrase	gyrase	NN
cord-016187-58rqc0cg	158	40	-	-	HYPH
cord-016187-58rqc0cg	158	41	bacterial	bacterial	JJ
cord-016187-58rqc0cg	158	42	DNA	dna	NN
cord-016187-58rqc0cg	158	43	complex	complex	NN
cord-016187-58rqc0cg	158	44	[	[	-LRB-
cord-016187-58rqc0cg	158	45	42	42	CD
cord-016187-58rqc0cg	158	46	]	]	-RRB-
cord-016187-58rqc0cg	158	47	.	.	.
cord-016187-58rqc0cg	159	1	There	there	EX
cord-016187-58rqc0cg	159	2	are	be	VBP
cord-016187-58rqc0cg	159	3	two	two	CD
cord-016187-58rqc0cg	159	4	common	common	JJ
cord-016187-58rqc0cg	159	5	genes	gene	NNS
cord-016187-58rqc0cg	159	6	that	that	WDT
cord-016187-58rqc0cg	159	7	mediate	mediate	VBP
cord-016187-58rqc0cg	159	8	resistance	resistance	NN
cord-016187-58rqc0cg	159	9	to	to	IN
cord-016187-58rqc0cg	159	10	sulfa	sulfa	NN
cord-016187-58rqc0cg	159	11	drugs	drug	NNS
cord-016187-58rqc0cg	159	12	in	in	IN
cord-016187-58rqc0cg	159	13	a	a	DT
cord-016187-58rqc0cg	159	14	wide	wide	JJ
cord-016187-58rqc0cg	159	15	variety	variety	NN
cord-016187-58rqc0cg	159	16	of	of	IN
cord-016187-58rqc0cg	159	17	pathogenic	pathogenic	JJ
cord-016187-58rqc0cg	159	18	bacteria	bacteria	NNS
cord-016187-58rqc0cg	159	19	.	.	.
cord-016187-58rqc0cg	160	1	These	these	DT
cord-016187-58rqc0cg	160	2	are	be	VBP
cord-016187-58rqc0cg	160	3	known	know	VBN
cord-016187-58rqc0cg	160	4	as	as	IN
cord-016187-58rqc0cg	160	5	sul1	sul1	NN
cord-016187-58rqc0cg	160	6	and	and	CC
cord-016187-58rqc0cg	160	7	sul2	sul2	NN
cord-016187-58rqc0cg	160	8	.	.	.
cord-016187-58rqc0cg	161	1	These	these	DT
cord-016187-58rqc0cg	161	2	genes	gene	NNS
cord-016187-58rqc0cg	161	3	give	give	VBP
cord-016187-58rqc0cg	161	4	rise	rise	NN
cord-016187-58rqc0cg	161	5	to	to	IN
cord-016187-58rqc0cg	161	6	altered	altered	JJ
cord-016187-58rqc0cg	161	7	forms	form	NNS
cord-016187-58rqc0cg	161	8	of	of	IN
cord-016187-58rqc0cg	161	9	the	the	DT
cord-016187-58rqc0cg	161	10	target	target	NN
cord-016187-58rqc0cg	161	11	enzyme	enzyme	NN
cord-016187-58rqc0cg	161	12	for	for	IN
cord-016187-58rqc0cg	161	13	sulfonamide	sulfonamide	NN
cord-016187-58rqc0cg	161	14	,	,	,
cord-016187-58rqc0cg	161	15	dihydropteroate	dihydropteroate	VB
cord-016187-58rqc0cg	161	16	synthase	synthase	NN
cord-016187-58rqc0cg	161	17	(	(	-LRB-
cord-016187-58rqc0cg	161	18	DHPS	DHPS	NNP
cord-016187-58rqc0cg	161	19	)	)	-RRB-
cord-016187-58rqc0cg	161	20	[	[	-LRB-
cord-016187-58rqc0cg	161	21	43	43	CD
cord-016187-58rqc0cg	161	22	]	]	-RRB-
cord-016187-58rqc0cg	161	23	.	.	.
cord-016187-58rqc0cg	162	1	The	the	DT
cord-016187-58rqc0cg	162	2	altered	alter	VBN
cord-016187-58rqc0cg	162	3	DHPS	DHPS	NNP
cord-016187-58rqc0cg	162	4	enzymes	enzyme	NNS
cord-016187-58rqc0cg	162	5	mediated	mediate	VBN
cord-016187-58rqc0cg	162	6	by	by	IN
cord-016187-58rqc0cg	162	7	the	the	DT
cord-016187-58rqc0cg	162	8	sulfonamide	sulfonamide	NN
cord-016187-58rqc0cg	162	9	resistance	resistance	NN
cord-016187-58rqc0cg	162	10	genes	gene	NNS
cord-016187-58rqc0cg	162	11	no	no	RB
cord-016187-58rqc0cg	162	12	longer	longer	RB
cord-016187-58rqc0cg	162	13	bind	bind	VBP
cord-016187-58rqc0cg	162	14	to	to	IN
cord-016187-58rqc0cg	162	15	sulfa	sulfa	NN
cord-016187-58rqc0cg	162	16	yet	yet	CC
cord-016187-58rqc0cg	162	17	continue	continue	VBP
cord-016187-58rqc0cg	162	18	to	to	TO
cord-016187-58rqc0cg	162	19	synthesize	synthesize	VB
cord-016187-58rqc0cg	162	20	dihydropteroate	dihydropteroate	NN
cord-016187-58rqc0cg	162	21	from	from	IN
cord-016187-58rqc0cg	162	22	para	para	NNP
cord-016187-58rqc0cg	162	23	-	-	HYPH
cord-016187-58rqc0cg	162	24	aminobenzoic	aminobenzoic	JJ
cord-016187-58rqc0cg	162	25	acid	acid	NN
cord-016187-58rqc0cg	162	26	substrate	substrate	NN
cord-016187-58rqc0cg	162	27	.	.	.
cord-016187-58rqc0cg	163	1	Trimethoprim	Trimethoprim	NNP
cord-016187-58rqc0cg	163	2	is	be	VBZ
cord-016187-58rqc0cg	163	3	a	a	DT
cord-016187-58rqc0cg	163	4	potent	potent	JJ
cord-016187-58rqc0cg	163	5	inhibitor	inhibitor	NN
cord-016187-58rqc0cg	163	6	of	of	IN
cord-016187-58rqc0cg	163	7	bacterial	bacterial	JJ
cord-016187-58rqc0cg	163	8	dihydrofolate	dihydrofolate	NN
cord-016187-58rqc0cg	163	9	reductase	reductase	NN
cord-016187-58rqc0cg	163	10	(	(	-LRB-
cord-016187-58rqc0cg	163	11	DHFR	DHFR	NNP
cord-016187-58rqc0cg	163	12	)	)	-RRB-
cord-016187-58rqc0cg	163	13	.	.	.
cord-016187-58rqc0cg	164	1	A	a	DT
cord-016187-58rqc0cg	164	2	large	large	JJ
cord-016187-58rqc0cg	164	3	number	number	NN
cord-016187-58rqc0cg	164	4	of	of	IN
cord-016187-58rqc0cg	164	5	altered	alter	VBN
cord-016187-58rqc0cg	164	6	DHFR	DHFR	NNP
cord-016187-58rqc0cg	164	7	enzymes	enzyme	NNS
cord-016187-58rqc0cg	164	8	with	with	IN
cord-016187-58rqc0cg	164	9	loss	loss	NN
cord-016187-58rqc0cg	164	10	of	of	IN
cord-016187-58rqc0cg	164	11	inhibition	inhibition	NN
cord-016187-58rqc0cg	164	12	by	by	IN
cord-016187-58rqc0cg	164	13	trimethoprim	trimethoprim	NNP
cord-016187-58rqc0cg	164	14	have	have	VBP
cord-016187-58rqc0cg	164	15	been	be	VBN
cord-016187-58rqc0cg	164	16	described	describe	VBN
cord-016187-58rqc0cg	164	17	from	from	IN
cord-016187-58rqc0cg	164	18	genes	gene	NNS
cord-016187-58rqc0cg	164	19	found	find	VBN
cord-016187-58rqc0cg	164	20	primarily	primarily	RB
cord-016187-58rqc0cg	164	21	on	on	IN
cord-016187-58rqc0cg	164	22	R	r	NN
cord-016187-58rqc0cg	164	23	plasmids	plasmid	NNS
cord-016187-58rqc0cg	164	24	.	.	.
cord-016187-58rqc0cg	165	1	These	these	DT
cord-016187-58rqc0cg	165	2	altered	alter	VBN
cord-016187-58rqc0cg	165	3	DHFR	DHFR	NNP
cord-016187-58rqc0cg	165	4	genes	gene	NNS
cord-016187-58rqc0cg	165	5	are	be	VBP
cord-016187-58rqc0cg	165	6	widespread	widespread	JJ
cord-016187-58rqc0cg	165	7	in	in	IN
cord-016187-58rqc0cg	165	8	Gram	gram	NN
cord-016187-58rqc0cg	165	9	-	-	HYPH
cord-016187-58rqc0cg	165	10	negative	negative	JJ
cord-016187-58rqc0cg	165	11	bacteria	bacteria	NNS
cord-016187-58rqc0cg	165	12	and	and	CC
cord-016187-58rqc0cg	165	13	are	be	VBP
cord-016187-58rqc0cg	165	14	also	also	RB
cord-016187-58rqc0cg	165	15	found	find	VBN
cord-016187-58rqc0cg	165	16	in	in	IN
cord-016187-58rqc0cg	165	17	staphylococci	staphylococcus	NNS
cord-016187-58rqc0cg	165	18	(	(	-LRB-
cord-016187-58rqc0cg	165	19	the	the	DT
cord-016187-58rqc0cg	165	20	dfrA	dfra	JJ
cord-016187-58rqc0cg	165	21	gene	gene	NN
cord-016187-58rqc0cg	165	22	)	)	-RRB-
cord-016187-58rqc0cg	165	23	[	[	-LRB-
cord-016187-58rqc0cg	165	24	44	44	CD
cord-016187-58rqc0cg	165	25	]	]	-RRB-
cord-016187-58rqc0cg	165	26	.	.	.
cord-016187-58rqc0cg	166	1	Tetracycline	Tetracycline	NNP
cord-016187-58rqc0cg	166	2	resistance	resistance	NN
cord-016187-58rqc0cg	166	3	may	may	MD
cord-016187-58rqc0cg	166	4	be	be	VB
cord-016187-58rqc0cg	166	5	mediated	mediate	VBN
cord-016187-58rqc0cg	166	6	by	by	IN
cord-016187-58rqc0cg	166	7	a	a	DT
cord-016187-58rqc0cg	166	8	mechanism	mechanism	NN
cord-016187-58rqc0cg	166	9	that	that	WDT
cord-016187-58rqc0cg	166	10	interferes	interfere	VBZ
cord-016187-58rqc0cg	166	11	with	with	IN
cord-016187-58rqc0cg	166	12	the	the	DT
cord-016187-58rqc0cg	166	13	ability	ability	NN
cord-016187-58rqc0cg	166	14	of	of	IN
cord-016187-58rqc0cg	166	15	tetracycline	tetracycline	NN
cord-016187-58rqc0cg	166	16	to	to	TO
cord-016187-58rqc0cg	166	17	bind	bind	VB
cord-016187-58rqc0cg	166	18	to	to	IN
cord-016187-58rqc0cg	166	19	the	the	DT
cord-016187-58rqc0cg	166	20	ribosome	ribosome	NN
cord-016187-58rqc0cg	166	21	.	.	.
cord-016187-58rqc0cg	167	1	The	the	DT
cord-016187-58rqc0cg	167	2	ubiquitous	ubiquitous	JJ
cord-016187-58rqc0cg	167	3	tetM	tetm	JJ
cord-016187-58rqc0cg	167	4	resistance	resistance	NN
cord-016187-58rqc0cg	167	5	gene	gene	NN
cord-016187-58rqc0cg	167	6	and	and	CC
cord-016187-58rqc0cg	167	7	related	relate	VBN
cord-016187-58rqc0cg	167	8	tetracycline	tetracycline	NN
cord-016187-58rqc0cg	167	9	resistance	resistance	NN
cord-016187-58rqc0cg	167	10	determinants	determinant	NNS
cord-016187-58rqc0cg	167	11	protect	protect	VBP
cord-016187-58rqc0cg	167	12	the	the	DT
cord-016187-58rqc0cg	167	13	ribosome	ribosome	NN
cord-016187-58rqc0cg	167	14	from	from	IN
cord-016187-58rqc0cg	167	15	tetracycline	tetracycline	NNP
cord-016187-58rqc0cg	167	16	action	action	NN
cord-016187-58rqc0cg	167	17	.	.	.
cord-016187-58rqc0cg	168	1	The	the	DT
cord-016187-58rqc0cg	168	2	tetM	tetm	JJ
cord-016187-58rqc0cg	168	3	gene	gene	NN
cord-016187-58rqc0cg	168	4	generates	generate	VBZ
cord-016187-58rqc0cg	168	5	protein	protein	NN
cord-016187-58rqc0cg	168	6	with	with	IN
cord-016187-58rqc0cg	168	7	elongation	elongation	NN
cord-016187-58rqc0cg	168	8	factor	factor	NN
cord-016187-58rqc0cg	168	9	-	-	HYPH
cord-016187-58rqc0cg	168	10	like	like	JJ
cord-016187-58rqc0cg	168	11	activity	activity	NN
cord-016187-58rqc0cg	168	12	that	that	WDT
cord-016187-58rqc0cg	168	13	may	may	MD
cord-016187-58rqc0cg	168	14	stabilize	stabilize	VB
cord-016187-58rqc0cg	168	15	ribosomal	ribosomal	JJ
cord-016187-58rqc0cg	168	16	transfer	transfer	NN
cord-016187-58rqc0cg	168	17	RNA	rna	NN
cord-016187-58rqc0cg	168	18	interactions	interaction	NNS
cord-016187-58rqc0cg	168	19	in	in	IN
cord-016187-58rqc0cg	168	20	the	the	DT
cord-016187-58rqc0cg	168	21	presence	presence	NN
cord-016187-58rqc0cg	168	22	of	of	IN
cord-016187-58rqc0cg	168	23	tetracycline	tetracycline	NN
cord-016187-58rqc0cg	168	24	molecules	molecule	NNS
cord-016187-58rqc0cg	168	25	[	[	-LRB-
cord-016187-58rqc0cg	168	26	45	45	CD
cord-016187-58rqc0cg	168	27	]	]	-RRB-
cord-016187-58rqc0cg	168	28	.	.	.
cord-016187-58rqc0cg	169	1	Sulfonamides	sulfonamide	NNS
cord-016187-58rqc0cg	169	2	compete	compete	VBP
cord-016187-58rqc0cg	169	3	with	with	IN
cord-016187-58rqc0cg	169	4	para	para	NNP
cord-016187-58rqc0cg	169	5	-	-	HYPH
cord-016187-58rqc0cg	169	6	aminobenzoic	aminobenzoic	NNP
cord-016187-58rqc0cg	169	7	acid	acid	NN
cord-016187-58rqc0cg	169	8	to	to	TO
cord-016187-58rqc0cg	169	9	bind	bind	VB
cord-016187-58rqc0cg	169	10	the	the	DT
cord-016187-58rqc0cg	169	11	enzyme	enzyme	NN
cord-016187-58rqc0cg	169	12	dihydropteroate	dihydropteroate	NN
cord-016187-58rqc0cg	169	13	synthase	synthase	NN
cord-016187-58rqc0cg	169	14	,	,	,
cord-016187-58rqc0cg	169	15	and	and	CC
cord-016187-58rqc0cg	169	16	thereby	thereby	RB
cord-016187-58rqc0cg	169	17	block	block	VB
cord-016187-58rqc0cg	169	18	folic	folic	JJ
cord-016187-58rqc0cg	169	19	acid	acid	NN
cord-016187-58rqc0cg	169	20	synthesis	synthesis	NN
cord-016187-58rqc0cg	169	21	necessary	necessary	JJ
cord-016187-58rqc0cg	169	22	for	for	IN
cord-016187-58rqc0cg	169	23	nucleic	nucleic	JJ
cord-016187-58rqc0cg	169	24	acid	acid	NN
cord-016187-58rqc0cg	169	25	synthesis	synthesis	NN
cord-016187-58rqc0cg	169	26	.	.	.
cord-016187-58rqc0cg	170	1	Sulfonamide	sulfonamide	NN
cord-016187-58rqc0cg	170	2	resistance	resistance	NN
cord-016187-58rqc0cg	170	3	may	may	MD
cord-016187-58rqc0cg	170	4	be	be	VB
cord-016187-58rqc0cg	170	5	mediated	mediate	VBN
cord-016187-58rqc0cg	170	6	in	in	IN
cord-016187-58rqc0cg	170	7	some	some	DT
cord-016187-58rqc0cg	170	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	170	9	by	by	IN
cord-016187-58rqc0cg	170	10	the	the	DT
cord-016187-58rqc0cg	170	11	over	over	JJ
cord-016187-58rqc0cg	170	12	production	production	NN
cord-016187-58rqc0cg	170	13	of	of	IN
cord-016187-58rqc0cg	170	14	the	the	DT
cord-016187-58rqc0cg	170	15	synthetic	synthetic	JJ
cord-016187-58rqc0cg	170	16	enzyme	enzyme	NN
cord-016187-58rqc0cg	170	17	dihydropteroate	dihydropteroate	NN
cord-016187-58rqc0cg	170	18	synthase	synthase	NN
cord-016187-58rqc0cg	170	19	.	.	.
cord-016187-58rqc0cg	171	1	The	the	DT
cord-016187-58rqc0cg	171	2	gene	gene	NN
cord-016187-58rqc0cg	171	3	responsible	responsible	JJ
cord-016187-58rqc0cg	171	4	for	for	IN
cord-016187-58rqc0cg	171	5	DHPS	DHPS	NNP
cord-016187-58rqc0cg	171	6	is	be	VBZ
cord-016187-58rqc0cg	171	7	felP	felp	JJ
cord-016187-58rqc0cg	171	8	and	and	CC
cord-016187-58rqc0cg	171	9	strains	strain	NNS
cord-016187-58rqc0cg	171	10	of	of	IN
cord-016187-58rqc0cg	171	11	bacteria	bacteria	NNS
cord-016187-58rqc0cg	171	12	that	that	WDT
cord-016187-58rqc0cg	171	13	produce	produce	VBP
cord-016187-58rqc0cg	171	14	excess	excess	JJ
cord-016187-58rqc0cg	171	15	DHPS	DHPS	NNP
cord-016187-58rqc0cg	171	16	can	can	MD
cord-016187-58rqc0cg	171	17	overwhelm	overwhelm	VB
cord-016187-58rqc0cg	171	18	sulfa	sulfa	NN
cord-016187-58rqc0cg	171	19	inhibition	inhibition	NN
cord-016187-58rqc0cg	171	20	[	[	-LRB-
cord-016187-58rqc0cg	171	21	43	43	CD
cord-016187-58rqc0cg	171	22	]	]	-RRB-
cord-016187-58rqc0cg	171	23	.	.	.
cord-016187-58rqc0cg	172	1	Trimethoprim	Trimethoprim	NNP
cord-016187-58rqc0cg	172	2	resistance	resistance	NN
cord-016187-58rqc0cg	172	3	may	may	MD
cord-016187-58rqc0cg	172	4	also	also	RB
cord-016187-58rqc0cg	172	5	occur	occur	VB
cord-016187-58rqc0cg	172	6	in	in	IN
cord-016187-58rqc0cg	172	7	a	a	DT
cord-016187-58rqc0cg	172	8	similar	similar	JJ
cord-016187-58rqc0cg	172	9	fashion	fashion	NN
cord-016187-58rqc0cg	172	10	,	,	,
cord-016187-58rqc0cg	172	11	by	by	IN
cord-016187-58rqc0cg	172	12	making	make	VBG
cord-016187-58rqc0cg	172	13	excess	excess	JJ
cord-016187-58rqc0cg	172	14	amounts	amount	NNS
cord-016187-58rqc0cg	172	15	of	of	IN
cord-016187-58rqc0cg	172	16	dihydrofolate	dihydrofolate	NN
cord-016187-58rqc0cg	172	17	reductase	reductase	NN
cord-016187-58rqc0cg	172	18	from	from	IN
cord-016187-58rqc0cg	172	19	the	the	DT
cord-016187-58rqc0cg	172	20	bacterial	bacterial	JJ
cord-016187-58rqc0cg	172	21	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	172	22	gene	gene	NN
cord-016187-58rqc0cg	172	23	folA	fola	VBP
cord-016187-58rqc0cg	172	24	[	[	-LRB-
cord-016187-58rqc0cg	172	25	44	44	CD
cord-016187-58rqc0cg	172	26	]	]	-RRB-
cord-016187-58rqc0cg	172	27	.	.	.
cord-016187-58rqc0cg	173	1	An	an	DT
cord-016187-58rqc0cg	173	2	unusual	unusual	JJ
cord-016187-58rqc0cg	173	3	mechanism	mechanism	NN
cord-016187-58rqc0cg	173	4	of	of	IN
cord-016187-58rqc0cg	173	5	resistance	resistance	NN
cord-016187-58rqc0cg	173	6	to	to	IN
cord-016187-58rqc0cg	173	7	specifi	specifi	NNP
cord-016187-58rqc0cg	173	8	c	c	NN
cord-016187-58rqc0cg	173	9	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	173	10	is	be	VBZ
cord-016187-58rqc0cg	173	11	by	by	IN
cord-016187-58rqc0cg	173	12	the	the	DT
cord-016187-58rqc0cg	173	13	development	development	NN
cord-016187-58rqc0cg	173	14	of	of	IN
cord-016187-58rqc0cg	173	15	auxotrophs	auxotrophs	NNP
cord-016187-58rqc0cg	173	16	,	,	,
cord-016187-58rqc0cg	173	17	which	which	WDT
cord-016187-58rqc0cg	173	18	have	have	VBP
cord-016187-58rqc0cg	173	19	specifi	specifi	VBN
cord-016187-58rqc0cg	173	20	c	c	NN
cord-016187-58rqc0cg	173	21	growth	growth	NN
cord-016187-58rqc0cg	173	22	factor	factor	NN
cord-016187-58rqc0cg	173	23	requirements	requirement	NNS
cord-016187-58rqc0cg	173	24	not	not	RB
cord-016187-58rqc0cg	173	25	seen	see	VBN
cord-016187-58rqc0cg	173	26	in	in	IN
cord-016187-58rqc0cg	173	27	wild	wild	JJ
cord-016187-58rqc0cg	173	28	-	-	HYPH
cord-016187-58rqc0cg	173	29	type	type	NN
cord-016187-58rqc0cg	173	30	strains	strain	NNS
cord-016187-58rqc0cg	173	31	.	.	.
cord-016187-58rqc0cg	174	1	These	these	DT
cord-016187-58rqc0cg	174	2	mutants	mutant	NNS
cord-016187-58rqc0cg	174	3	require	require	VBP
cord-016187-58rqc0cg	174	4	substrates	substrate	NNS
cord-016187-58rqc0cg	174	5	that	that	WDT
cord-016187-58rqc0cg	174	6	normally	normally	RB
cord-016187-58rqc0cg	174	7	are	be	VBP
cord-016187-58rqc0cg	174	8	synthesized	synthesize	VBN
cord-016187-58rqc0cg	174	9	by	by	IN
cord-016187-58rqc0cg	174	10	the	the	DT
cord-016187-58rqc0cg	174	11	target	target	NN
cord-016187-58rqc0cg	174	12	enzymes	enzyme	NNS
cord-016187-58rqc0cg	174	13	,	,	,
cord-016187-58rqc0cg	174	14	and	and	CC
cord-016187-58rqc0cg	174	15	thus	thus	RB
cord-016187-58rqc0cg	174	16	if	if	IN
cord-016187-58rqc0cg	174	17	the	the	DT
cord-016187-58rqc0cg	174	18	substrates	substrate	NNS
cord-016187-58rqc0cg	174	19	are	be	VBP
cord-016187-58rqc0cg	174	20	present	present	JJ
cord-016187-58rqc0cg	174	21	in	in	IN
cord-016187-58rqc0cg	174	22	the	the	DT
cord-016187-58rqc0cg	174	23	environment	environment	NN
cord-016187-58rqc0cg	174	24	,	,	,
cord-016187-58rqc0cg	174	25	the	the	DT
cord-016187-58rqc0cg	174	26	organisms	organism	NNS
cord-016187-58rqc0cg	174	27	are	be	VBP
cord-016187-58rqc0cg	174	28	able	able	JJ
cord-016187-58rqc0cg	174	29	to	to	TO
cord-016187-58rqc0cg	174	30	grow	grow	VB
cord-016187-58rqc0cg	174	31	despite	despite	IN
cord-016187-58rqc0cg	174	32	inhibition	inhibition	NN
cord-016187-58rqc0cg	174	33	of	of	IN
cord-016187-58rqc0cg	174	34	the	the	DT
cord-016187-58rqc0cg	174	35	synthetic	synthetic	JJ
cord-016187-58rqc0cg	174	36	enzyme	enzyme	NN
cord-016187-58rqc0cg	174	37	by	by	IN
cord-016187-58rqc0cg	174	38	an	an	DT
cord-016187-58rqc0cg	174	39	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	174	40	.	.	.
cord-016187-58rqc0cg	175	1	Bacteria	Bacteria	NNS
cord-016187-58rqc0cg	175	2	that	that	WDT
cord-016187-58rqc0cg	175	3	lose	lose	VBP
cord-016187-58rqc0cg	175	4	the	the	DT
cord-016187-58rqc0cg	175	5	enzyme	enzyme	NN
cord-016187-58rqc0cg	176	1	thymidylate	thymidylate	NNP
cord-016187-58rqc0cg	176	2	synthetase	synthetase	NNP
cord-016187-58rqc0cg	176	3	are	be	VBP
cord-016187-58rqc0cg	176	4	'	'	``
cord-016187-58rqc0cg	176	5	thymine	thymine	NN
cord-016187-58rqc0cg	176	6	dependent	dependent	NN
cord-016187-58rqc0cg	176	7	'	'	''
cord-016187-58rqc0cg	176	8	.	.	.
cord-016187-58rqc0cg	177	1	If	if	IN
cord-016187-58rqc0cg	177	2	they	-PRON-	PRP
cord-016187-58rqc0cg	177	3	can	can	MD
cord-016187-58rqc0cg	177	4	acquire	acquire	VB
cord-016187-58rqc0cg	177	5	exogenous	exogenous	JJ
cord-016187-58rqc0cg	177	6	supplies	supply	NNS
cord-016187-58rqc0cg	177	7	of	of	IN
cord-016187-58rqc0cg	177	8	thymidine	thymidine	NN
cord-016187-58rqc0cg	177	9	to	to	TO
cord-016187-58rqc0cg	177	10	synthesize	synthesize	VB
cord-016187-58rqc0cg	177	11	thymidylate	thymidylate	NN
cord-016187-58rqc0cg	177	12	via	via	IN
cord-016187-58rqc0cg	177	13	salvage	salvage	NN
cord-016187-58rqc0cg	177	14	pathways	pathway	NNS
cord-016187-58rqc0cg	177	15	from	from	IN
cord-016187-58rqc0cg	177	16	the	the	DT
cord-016187-58rqc0cg	177	17	host	host	NN
cord-016187-58rqc0cg	177	18	,	,	,
cord-016187-58rqc0cg	177	19	they	-PRON-	PRP
cord-016187-58rqc0cg	177	20	are	be	VBP
cord-016187-58rqc0cg	177	21	highly	highly	RB
cord-016187-58rqc0cg	177	22	resistant	resistant	JJ
cord-016187-58rqc0cg	177	23	to	to	IN
cord-016187-58rqc0cg	177	24	sulfa	sulfa	NN
cord-016187-58rqc0cg	177	25	drugs	drug	NNS
cord-016187-58rqc0cg	177	26	and	and	CC
cord-016187-58rqc0cg	177	27	trimethoprim	trimethoprim	NNP
cord-016187-58rqc0cg	177	28	[	[	-LRB-
cord-016187-58rqc0cg	177	29	23	23	CD
cord-016187-58rqc0cg	177	30	]	]	-RRB-
cord-016187-58rqc0cg	177	31	.	.	.
cord-016187-58rqc0cg	178	1	Once	once	RB
cord-016187-58rqc0cg	178	2	an	an	DT
cord-016187-58rqc0cg	178	3	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	178	4	resistance	resistance	NN
cord-016187-58rqc0cg	178	5	gene	gene	NN
cord-016187-58rqc0cg	178	6	evolves	evolve	VBZ
cord-016187-58rqc0cg	178	7	,	,	,
cord-016187-58rqc0cg	178	8	the	the	DT
cord-016187-58rqc0cg	178	9	resistance	resistance	NN
cord-016187-58rqc0cg	178	10	determinant	determinant	NN
cord-016187-58rqc0cg	178	11	can	can	MD
cord-016187-58rqc0cg	178	12	disseminate	disseminate	VB
cord-016187-58rqc0cg	178	13	among	among	IN
cord-016187-58rqc0cg	178	14	bacterial	bacterial	JJ
cord-016187-58rqc0cg	178	15	populations	population	NNS
cord-016187-58rqc0cg	178	16	by	by	IN
cord-016187-58rqc0cg	178	17	transformation	transformation	NN
cord-016187-58rqc0cg	178	18	,	,	,
cord-016187-58rqc0cg	178	19	transduction	transduction	NN
cord-016187-58rqc0cg	178	20	,	,	,
cord-016187-58rqc0cg	178	21	conjugation	conjugation	NN
cord-016187-58rqc0cg	178	22	,	,	,
cord-016187-58rqc0cg	178	23	or	or	CC
cord-016187-58rqc0cg	178	24	transposition	transposition	NN
cord-016187-58rqc0cg	178	25	.	.	.
cord-016187-58rqc0cg	179	1	Favored	favor	VBN
cord-016187-58rqc0cg	179	2	clones	clone	NNS
cord-016187-58rqc0cg	179	3	of	of	IN
cord-016187-58rqc0cg	179	4	bacteria	bacteria	NNS
cord-016187-58rqc0cg	179	5	then	then	RB
cord-016187-58rqc0cg	179	6	proliferate	proliferate	VBP
cord-016187-58rqc0cg	179	7	in	in	IN
cord-016187-58rqc0cg	179	8	the	the	DT
cord-016187-58rqc0cg	179	9	fl	fl	NNP
cord-016187-58rqc0cg	179	10	ora	ora	NN
cord-016187-58rqc0cg	179	11	of	of	IN
cord-016187-58rqc0cg	179	12	patients	patient	NNS
cord-016187-58rqc0cg	179	13	who	who	WP
cord-016187-58rqc0cg	179	14	receive	receive	VBP
cord-016187-58rqc0cg	179	15	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	179	16	.	.	.
cord-016187-58rqc0cg	180	1	Antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	180	2	-	-	HYPH
cord-016187-58rqc0cg	180	3	resistance	resistance	NN
cord-016187-58rqc0cg	180	4	genes	gene	NNS
cord-016187-58rqc0cg	180	5	were	be	VBD
cord-016187-58rqc0cg	180	6	found	find	VBN
cord-016187-58rqc0cg	180	7	among	among	IN
cord-016187-58rqc0cg	180	8	bacteria	bacteria	NNS
cord-016187-58rqc0cg	180	9	even	even	RB
cord-016187-58rqc0cg	180	10	in	in	IN
cord-016187-58rqc0cg	180	11	the	the	DT
cord-016187-58rqc0cg	180	12	pre	pre	JJ
cord-016187-58rqc0cg	180	13	-	-	JJ
cord-016187-58rqc0cg	180	14	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	180	15	therapy	therapy	NN
cord-016187-58rqc0cg	180	16	era	era	NN
cord-016187-58rqc0cg	180	17	[	[	-LRB-
cord-016187-58rqc0cg	180	18	23	23	CD
cord-016187-58rqc0cg	180	19	]	]	-RRB-
cord-016187-58rqc0cg	180	20	.	.	.
cord-016187-58rqc0cg	181	1	However	however	RB
cord-016187-58rqc0cg	181	2	,	,	,
cord-016187-58rqc0cg	181	3	selection	selection	NN
cord-016187-58rqc0cg	181	4	pressures	pressure	NNS
cord-016187-58rqc0cg	181	5	placed	place	VBN
cord-016187-58rqc0cg	181	6	upon	upon	IN
cord-016187-58rqc0cg	181	7	microbial	microbial	JJ
cord-016187-58rqc0cg	181	8	populations	population	NNS
cord-016187-58rqc0cg	181	9	by	by	IN
cord-016187-58rqc0cg	181	10	a	a	DT
cord-016187-58rqc0cg	181	11	highly	highly	RB
cord-016187-58rqc0cg	181	12	lethal	lethal	JJ
cord-016187-58rqc0cg	181	13	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	181	14	compound	compound	NN
cord-016187-58rqc0cg	181	15	create	create	VBP
cord-016187-58rqc0cg	181	16	an	an	DT
cord-016187-58rqc0cg	181	17	environment	environment	NN
cord-016187-58rqc0cg	181	18	in	in	IN
cord-016187-58rqc0cg	181	19	which	which	WDT
cord-016187-58rqc0cg	181	20	individual	individual	JJ
cord-016187-58rqc0cg	181	21	clones	clone	NNS
cord-016187-58rqc0cg	181	22	that	that	WDT
cord-016187-58rqc0cg	181	23	resist	resist	VBP
cord-016187-58rqc0cg	181	24	the	the	DT
cord-016187-58rqc0cg	181	25	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	181	26	are	be	VBP
cord-016187-58rqc0cg	181	27	markedly	markedly	RB
cord-016187-58rqc0cg	181	28	favored	favor	VBN
cord-016187-58rqc0cg	181	29	.	.	.
cord-016187-58rqc0cg	182	1	These	these	DT
cord-016187-58rqc0cg	182	2	resistant	resistant	JJ
cord-016187-58rqc0cg	182	3	populations	population	NNS
cord-016187-58rqc0cg	182	4	then	then	RB
cord-016187-58rqc0cg	182	5	proliferate	proliferate	VBP
cord-016187-58rqc0cg	182	6	and	and	CC
cord-016187-58rqc0cg	182	7	rapidly	rapidly	RB
cord-016187-58rqc0cg	182	8	replace	replace	VB
cord-016187-58rqc0cg	182	9	other	other	JJ
cord-016187-58rqc0cg	182	10	susceptible	susceptible	JJ
cord-016187-58rqc0cg	182	11	strains	strain	NNS
cord-016187-58rqc0cg	182	12	of	of	IN
cord-016187-58rqc0cg	182	13	bacteria	bacteria	NNS
cord-016187-58rqc0cg	182	14	.	.	.
cord-016187-58rqc0cg	183	1	While	while	IN
cord-016187-58rqc0cg	183	2	some	some	DT
cord-016187-58rqc0cg	183	3	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	183	4	resistance	resistance	NN
cord-016187-58rqc0cg	183	5	genes	gene	NNS
cord-016187-58rqc0cg	183	6	place	place	VBP
cord-016187-58rqc0cg	183	7	a	a	DT
cord-016187-58rqc0cg	183	8	metabolic	metabolic	JJ
cord-016187-58rqc0cg	183	9	'	'	``
cord-016187-58rqc0cg	183	10	cost	cost	NN
cord-016187-58rqc0cg	183	11	'	'	''
cord-016187-58rqc0cg	183	12	on	on	IN
cord-016187-58rqc0cg	183	13	bacteria	bacteria	NNS
cord-016187-58rqc0cg	183	14	,	,	,
cord-016187-58rqc0cg	183	15	many	many	JJ
cord-016187-58rqc0cg	183	16	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	183	17	have	have	VBP
cord-016187-58rqc0cg	183	18	evolved	evolve	VBN
cord-016187-58rqc0cg	183	19	strategies	strategy	NNS
cord-016187-58rqc0cg	183	20	to	to	TO
cord-016187-58rqc0cg	183	21	limit	limit	VB
cord-016187-58rqc0cg	183	22	this	this	DT
cord-016187-58rqc0cg	183	23	cost	cost	NN
cord-016187-58rqc0cg	183	24	by	by	IN
cord-016187-58rqc0cg	183	25	limiting	limit	VBG
cord-016187-58rqc0cg	183	26	expression	expression	NN
cord-016187-58rqc0cg	183	27	,	,	,
cord-016187-58rqc0cg	183	28	alternate	alternate	JJ
cord-016187-58rqc0cg	183	29	gene	gene	NN
cord-016187-58rqc0cg	183	30	products	product	NNS
cord-016187-58rqc0cg	183	31	or	or	CC
cord-016187-58rqc0cg	183	32	phase	phase	NN
cord-016187-58rqc0cg	183	33	variation	variation	NN
cord-016187-58rqc0cg	183	34	.	.	.
cord-016187-58rqc0cg	184	1	These	these	DT
cord-016187-58rqc0cg	184	2	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	184	3	allow	allow	VBP
cord-016187-58rqc0cg	184	4	favorable	favorable	JJ
cord-016187-58rqc0cg	184	5	but	but	CC
cord-016187-58rqc0cg	184	6	sometimes	sometimes	RB
cord-016187-58rqc0cg	184	7	'	'	``
cord-016187-58rqc0cg	184	8	costly	costly	JJ
cord-016187-58rqc0cg	184	9	'	'	''
cord-016187-58rqc0cg	184	10	genes	gene	NNS
cord-016187-58rqc0cg	184	11	that	that	WDT
cord-016187-58rqc0cg	184	12	mediate	mediate	VBP
cord-016187-58rqc0cg	184	13	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	184	14	resistance	resistance	NN
cord-016187-58rqc0cg	184	15	to	to	TO
cord-016187-58rqc0cg	184	16	persist	persist	VB
cord-016187-58rqc0cg	184	17	in	in	IN
cord-016187-58rqc0cg	184	18	the	the	DT
cord-016187-58rqc0cg	184	19	absence	absence	NN
cord-016187-58rqc0cg	184	20	of	of	IN
cord-016187-58rqc0cg	184	21	continued	continue	VBN
cord-016187-58rqc0cg	184	22	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	184	23	selection	selection	NN
cord-016187-58rqc0cg	184	24	pressure	pressure	NN
cord-016187-58rqc0cg	184	25	and	and	CC
cord-016187-58rqc0cg	184	26	yet	yet	RB
cord-016187-58rqc0cg	184	27	be	be	VB
cord-016187-58rqc0cg	184	28	rapidly	rapidly	RB
cord-016187-58rqc0cg	184	29	expressed	express	VBN
cord-016187-58rqc0cg	184	30	upon	upon	IN
cord-016187-58rqc0cg	184	31	re	re	NN
cord-016187-58rqc0cg	184	32	-	-	NN
cord-016187-58rqc0cg	184	33	exposure	exposure	NN
cord-016187-58rqc0cg	184	34	to	to	IN
cord-016187-58rqc0cg	184	35	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	184	36	[	[	-LRB-
cord-016187-58rqc0cg	184	37	46	46	CD
cord-016187-58rqc0cg	184	38	]	]	-RRB-
cord-016187-58rqc0cg	184	39	.	.	.
cord-016187-58rqc0cg	185	1	Plasmids	plasmid	NNS
cord-016187-58rqc0cg	185	2	are	be	VBP
cord-016187-58rqc0cg	185	3	particularly	particularly	RB
cord-016187-58rqc0cg	185	4	well	well	RB
cord-016187-58rqc0cg	185	5	adapted	adapt	VBN
cord-016187-58rqc0cg	185	6	to	to	TO
cord-016187-58rqc0cg	185	7	serve	serve	VB
cord-016187-58rqc0cg	185	8	as	as	IN
cord-016187-58rqc0cg	185	9	agents	agent	NNS
cord-016187-58rqc0cg	185	10	of	of	IN
cord-016187-58rqc0cg	185	11	genetic	genetic	JJ
cord-016187-58rqc0cg	185	12	evolution	evolution	NN
cord-016187-58rqc0cg	185	13	and	and	CC
cord-016187-58rqc0cg	185	14	R	r	NN
cord-016187-58rqc0cg	185	15	-	-	HYPH
cord-016187-58rqc0cg	185	16	gene	gene	NN
cord-016187-58rqc0cg	185	17	dissemination	dissemination	NN
cord-016187-58rqc0cg	185	18	.	.	.
cord-016187-58rqc0cg	186	1	Plasmids	plasmid	NNS
cord-016187-58rqc0cg	186	2	are	be	VBP
cord-016187-58rqc0cg	186	3	extrachromosomal	extrachromosomal	VBG
cord-016187-58rqc0cg	186	4	genetic	genetic	JJ
cord-016187-58rqc0cg	186	5	elements	element	NNS
cord-016187-58rqc0cg	186	6	that	that	WDT
cord-016187-58rqc0cg	186	7	are	be	VBP
cord-016187-58rqc0cg	186	8	made	make	VBN
cord-016187-58rqc0cg	186	9	of	of	IN
cord-016187-58rqc0cg	186	10	circular	circular	JJ
cord-016187-58rqc0cg	186	11	double	double	RB
cord-016187-58rqc0cg	186	12	-	-	HYPH
cord-016187-58rqc0cg	186	13	stranded	strand	VBN
cord-016187-58rqc0cg	186	14	DNA	dna	NN
cord-016187-58rqc0cg	186	15	molecules	molecule	NNS
cord-016187-58rqc0cg	186	16	that	that	WDT
cord-016187-58rqc0cg	186	17	range	range	VBP
cord-016187-58rqc0cg	186	18	from	from	IN
cord-016187-58rqc0cg	186	19	less	less	JJR
cord-016187-58rqc0cg	186	20	than	than	IN
cord-016187-58rqc0cg	186	21	10	10	CD
cord-016187-58rqc0cg	186	22	to	to	IN
cord-016187-58rqc0cg	186	23	greater	great	JJR
cord-016187-58rqc0cg	186	24	than	than	IN
cord-016187-58rqc0cg	186	25	400	400	CD
cord-016187-58rqc0cg	186	26	kilobase	kilobase	NN
cord-016187-58rqc0cg	186	27	pairs	pair	NNS
cord-016187-58rqc0cg	186	28	and	and	CC
cord-016187-58rqc0cg	186	29	are	be	VBP
cord-016187-58rqc0cg	186	30	extremely	extremely	RB
cord-016187-58rqc0cg	186	31	common	common	JJ
cord-016187-58rqc0cg	186	32	in	in	IN
cord-016187-58rqc0cg	186	33	clinical	clinical	JJ
cord-016187-58rqc0cg	186	34	isolates	isolate	NNS
cord-016187-58rqc0cg	186	35	of	of	IN
cord-016187-58rqc0cg	186	36	bacterial	bacterial	JJ
cord-016187-58rqc0cg	186	37	pathogens	pathogen	NNS
cord-016187-58rqc0cg	186	38	.	.	.
cord-016187-58rqc0cg	187	1	Although	although	IN
cord-016187-58rqc0cg	187	2	multiple	multiple	JJ
cord-016187-58rqc0cg	187	3	copies	copy	NNS
cord-016187-58rqc0cg	187	4	of	of	IN
cord-016187-58rqc0cg	187	5	a	a	DT
cord-016187-58rqc0cg	187	6	specifi	specifi	NN
cord-016187-58rqc0cg	187	7	c	c	NN
cord-016187-58rqc0cg	187	8	plasmid	plasmid	NN
cord-016187-58rqc0cg	187	9	or	or	CC
cord-016187-58rqc0cg	187	10	multiple	multiple	JJ
cord-016187-58rqc0cg	187	11	different	different	JJ
cord-016187-58rqc0cg	187	12	plasmids	plasmid	NNS
cord-016187-58rqc0cg	187	13	,	,	,
cord-016187-58rqc0cg	187	14	or	or	CC
cord-016187-58rqc0cg	187	15	both	both	DT
cord-016187-58rqc0cg	187	16	,	,	,
cord-016187-58rqc0cg	187	17	may	may	MD
cord-016187-58rqc0cg	187	18	be	be	VB
cord-016187-58rqc0cg	187	19	found	find	VBN
cord-016187-58rqc0cg	187	20	in	in	IN
cord-016187-58rqc0cg	187	21	a	a	DT
cord-016187-58rqc0cg	187	22	single	single	JJ
cord-016187-58rqc0cg	187	23	bacterial	bacterial	JJ
cord-016187-58rqc0cg	187	24	cell	cell	NN
cord-016187-58rqc0cg	187	25	,	,	,
cord-016187-58rqc0cg	187	26	closely	closely	RB
cord-016187-58rqc0cg	187	27	related	related	JJ
cord-016187-58rqc0cg	187	28	plasmids	plasmid	NNS
cord-016187-58rqc0cg	187	29	often	often	RB
cord-016187-58rqc0cg	187	30	can	can	MD
cord-016187-58rqc0cg	187	31	not	not	RB
cord-016187-58rqc0cg	187	32	coexist	coexist	VB
cord-016187-58rqc0cg	187	33	in	in	IN
cord-016187-58rqc0cg	187	34	the	the	DT
cord-016187-58rqc0cg	187	35	same	same	JJ
cord-016187-58rqc0cg	187	36	cell	cell	NN
cord-016187-58rqc0cg	187	37	.	.	.
cord-016187-58rqc0cg	188	1	This	this	DT
cord-016187-58rqc0cg	188	2	observation	observation	NN
cord-016187-58rqc0cg	188	3	has	have	VBZ
cord-016187-58rqc0cg	188	4	led	lead	VBN
cord-016187-58rqc0cg	188	5	to	to	IN
cord-016187-58rqc0cg	188	6	a	a	DT
cord-016187-58rqc0cg	188	7	classifi	classifi	NN
cord-016187-58rqc0cg	188	8	cation	cation	NN
cord-016187-58rqc0cg	188	9	scheme	scheme	NN
cord-016187-58rqc0cg	188	10	of	of	IN
cord-016187-58rqc0cg	188	11	plasmids	plasmid	NNS
cord-016187-58rqc0cg	188	12	based	base	VBN
cord-016187-58rqc0cg	188	13	upon	upon	IN
cord-016187-58rqc0cg	188	14	incompatibility	incompatibility	NN
cord-016187-58rqc0cg	188	15	groups	group	NNS
cord-016187-58rqc0cg	188	16	[	[	-LRB-
cord-016187-58rqc0cg	188	17	23	23	CD
cord-016187-58rqc0cg	188	18	]	]	-RRB-
cord-016187-58rqc0cg	188	19	.	.	.
cord-016187-58rqc0cg	189	1	Plasmids	plasmid	NNS
cord-016187-58rqc0cg	189	2	may	may	MD
cord-016187-58rqc0cg	189	3	determine	determine	VB
cord-016187-58rqc0cg	189	4	a	a	DT
cord-016187-58rqc0cg	189	5	wide	wide	JJ
cord-016187-58rqc0cg	189	6	range	range	NN
cord-016187-58rqc0cg	189	7	of	of	IN
cord-016187-58rqc0cg	189	8	functions	function	NNS
cord-016187-58rqc0cg	189	9	besides	besides	IN
cord-016187-58rqc0cg	189	10	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	189	11	resistance	resistance	NN
cord-016187-58rqc0cg	189	12	,	,	,
cord-016187-58rqc0cg	189	13	including	include	VBG
cord-016187-58rqc0cg	189	14	virulence	virulence	NN
cord-016187-58rqc0cg	189	15	and	and	CC
cord-016187-58rqc0cg	189	16	metabolic	metabolic	JJ
cord-016187-58rqc0cg	189	17	capacities	capacity	NNS
cord-016187-58rqc0cg	189	18	.	.	.
cord-016187-58rqc0cg	190	1	Plasmids	plasmid	NNS
cord-016187-58rqc0cg	190	2	are	be	VBP
cord-016187-58rqc0cg	190	3	autonomous	autonomous	JJ
cord-016187-58rqc0cg	190	4	,	,	,
cord-016187-58rqc0cg	190	5	self	self	NN
cord-016187-58rqc0cg	190	6	-	-	HYPH
cord-016187-58rqc0cg	190	7	replicating	replicate	VBG
cord-016187-58rqc0cg	190	8	genetic	genetic	JJ
cord-016187-58rqc0cg	190	9	elements	element	NNS
cord-016187-58rqc0cg	190	10	that	that	WDT
cord-016187-58rqc0cg	190	11	possess	possess	VBP
cord-016187-58rqc0cg	190	12	an	an	DT
cord-016187-58rqc0cg	190	13	origin	origin	NN
cord-016187-58rqc0cg	190	14	for	for	IN
cord-016187-58rqc0cg	190	15	replication	replication	NN
cord-016187-58rqc0cg	190	16	and	and	CC
cord-016187-58rqc0cg	190	17	genes	gene	NNS
cord-016187-58rqc0cg	190	18	that	that	WDT
cord-016187-58rqc0cg	190	19	facilitate	facilitate	VBP
cord-016187-58rqc0cg	190	20	its	-PRON-	PRP$
cord-016187-58rqc0cg	190	21	stable	stable	JJ
cord-016187-58rqc0cg	190	22	maintenance	maintenance	NN
cord-016187-58rqc0cg	190	23	in	in	IN
cord-016187-58rqc0cg	190	24	host	host	NN
cord-016187-58rqc0cg	190	25	bacteria	bacteria	NNS
cord-016187-58rqc0cg	190	26	.	.	.
cord-016187-58rqc0cg	191	1	Conjugative	conjugative	JJ
cord-016187-58rqc0cg	191	2	plasmids	plasmid	NNS
cord-016187-58rqc0cg	191	3	require	require	VBP
cord-016187-58rqc0cg	191	4	additional	additional	JJ
cord-016187-58rqc0cg	191	5	genes	gene	NNS
cord-016187-58rqc0cg	191	6	that	that	WDT
cord-016187-58rqc0cg	191	7	can	can	MD
cord-016187-58rqc0cg	191	8	initiate	initiate	VB
cord-016187-58rqc0cg	191	9	self	self	NN
cord-016187-58rqc0cg	191	10	-	-	HYPH
cord-016187-58rqc0cg	191	11	transfer	transfer	NN
cord-016187-58rqc0cg	191	12	.	.	.
cord-016187-58rqc0cg	192	1	The	the	DT
cord-016187-58rqc0cg	192	2	transfer	transfer	NN
cord-016187-58rqc0cg	192	3	of	of	IN
cord-016187-58rqc0cg	192	4	plasmid	plasmid	NN
cord-016187-58rqc0cg	192	5	DNA	dna	NN
cord-016187-58rqc0cg	192	6	between	between	IN
cord-016187-58rqc0cg	192	7	bacterial	bacterial	JJ
cord-016187-58rqc0cg	192	8	species	specie	NNS
cord-016187-58rqc0cg	192	9	is	be	VBZ
cord-016187-58rqc0cg	192	10	a	a	DT
cord-016187-58rqc0cg	192	11	complex	complex	JJ
cord-016187-58rqc0cg	192	12	process	process	NN
cord-016187-58rqc0cg	192	13	,	,	,
cord-016187-58rqc0cg	192	14	and	and	CC
cord-016187-58rqc0cg	192	15	thus	thus	RB
cord-016187-58rqc0cg	192	16	conjugative	conjugative	JJ
cord-016187-58rqc0cg	192	17	plasmids	plasmid	NNS
cord-016187-58rqc0cg	192	18	tend	tend	VBP
cord-016187-58rqc0cg	192	19	to	to	TO
cord-016187-58rqc0cg	192	20	be	be	VB
cord-016187-58rqc0cg	192	21	larger	large	JJR
cord-016187-58rqc0cg	192	22	than	than	IN
cord-016187-58rqc0cg	192	23	non	non	JJ
cord-016187-58rqc0cg	192	24	-	-	JJ
cord-016187-58rqc0cg	192	25	conjugative	conjugative	JJ
cord-016187-58rqc0cg	192	26	ones	one	NNS
cord-016187-58rqc0cg	192	27	.	.	.
cord-016187-58rqc0cg	193	1	Some	some	DT
cord-016187-58rqc0cg	193	2	small	small	JJ
cord-016187-58rqc0cg	193	3	plasmids	plasmid	NNS
cord-016187-58rqc0cg	193	4	may	may	MD
cord-016187-58rqc0cg	193	5	be	be	VB
cord-016187-58rqc0cg	193	6	able	able	JJ
cord-016187-58rqc0cg	193	7	to	to	TO
cord-016187-58rqc0cg	193	8	utilize	utilize	VB
cord-016187-58rqc0cg	193	9	the	the	DT
cord-016187-58rqc0cg	193	10	conjugation	conjugation	NN
cord-016187-58rqc0cg	193	11	apparatus	apparatus	NN
cord-016187-58rqc0cg	193	12	of	of	IN
cord-016187-58rqc0cg	193	13	a	a	DT
cord-016187-58rqc0cg	193	14	coresident	coresident	NN
cord-016187-58rqc0cg	193	15	conjugative	conjugative	JJ
cord-016187-58rqc0cg	193	16	plasmid	plasmid	NN
cord-016187-58rqc0cg	193	17	.	.	.
cord-016187-58rqc0cg	194	1	Many	many	JJ
cord-016187-58rqc0cg	194	2	plasmid	plasmid	NN
cord-016187-58rqc0cg	194	3	-	-	HYPH
cord-016187-58rqc0cg	194	4	encoded	encode	VBN
cord-016187-58rqc0cg	194	5	functions	function	NNS
cord-016187-58rqc0cg	194	6	enable	enable	VBP
cord-016187-58rqc0cg	194	7	bacterial	bacterial	JJ
cord-016187-58rqc0cg	194	8	strains	strain	NNS
cord-016187-58rqc0cg	194	9	to	to	TO
cord-016187-58rqc0cg	194	10	persist	persist	VB
cord-016187-58rqc0cg	194	11	in	in	IN
cord-016187-58rqc0cg	194	12	the	the	DT
cord-016187-58rqc0cg	194	13	environment	environment	NN
cord-016187-58rqc0cg	194	14	by	by	IN
cord-016187-58rqc0cg	194	15	resisting	resist	VBG
cord-016187-58rqc0cg	194	16	noxious	noxious	JJ
cord-016187-58rqc0cg	194	17	agents	agent	NNS
cord-016187-58rqc0cg	194	18	,	,	,
cord-016187-58rqc0cg	194	19	such	such	JJ
cord-016187-58rqc0cg	194	20	as	as	IN
cord-016187-58rqc0cg	194	21	heavy	heavy	JJ
cord-016187-58rqc0cg	194	22	metals	metal	NNS
cord-016187-58rqc0cg	194	23	.	.	.
cord-016187-58rqc0cg	195	1	Mercury	Mercury	NNP
cord-016187-58rqc0cg	195	2	released	release	VBN
cord-016187-58rqc0cg	195	3	from	from	IN
cord-016187-58rqc0cg	195	4	dental	dental	NNP
cord-016187-58rqc0cg	195	5	fi	fi	NNP
cord-016187-58rqc0cg	195	6	llings	lling	NNS
cord-016187-58rqc0cg	195	7	may	may	MD
cord-016187-58rqc0cg	195	8	increase	increase	VB
cord-016187-58rqc0cg	195	9	the	the	DT
cord-016187-58rqc0cg	195	10	number	number	NN
cord-016187-58rqc0cg	195	11	of	of	IN
cord-016187-58rqc0cg	195	12	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	195	13	-	-	HYPH
cord-016187-58rqc0cg	195	14	resistant	resistant	JJ
cord-016187-58rqc0cg	195	15	bacteria	bacteria	NNS
cord-016187-58rqc0cg	195	16	in	in	IN
cord-016187-58rqc0cg	195	17	the	the	DT
cord-016187-58rqc0cg	195	18	oral	oral	JJ
cord-016187-58rqc0cg	195	19	fl	fl	NNP
cord-016187-58rqc0cg	195	20	ora	ora	NNP
cord-016187-58rqc0cg	195	21	.	.	.
cord-016187-58rqc0cg	196	1	Hexachlorophene	hexachlorophene	JJ
cord-016187-58rqc0cg	196	2	and	and	CC
cord-016187-58rqc0cg	196	3	other	other	JJ
cord-016187-58rqc0cg	196	4	topical	topical	JJ
cord-016187-58rqc0cg	196	5	bacteriostatic	bacteriostatic	JJ
cord-016187-58rqc0cg	196	6	agents	agent	NNS
cord-016187-58rqc0cg	196	7	in	in	IN
cord-016187-58rqc0cg	196	8	the	the	DT
cord-016187-58rqc0cg	196	9	environment	environment	NN
cord-016187-58rqc0cg	196	10	may	may	MD
cord-016187-58rqc0cg	196	11	actually	actually	RB
cord-016187-58rqc0cg	196	12	promote	promote	VB
cord-016187-58rqc0cg	196	13	plasmid	plasmid	NN
cord-016187-58rqc0cg	196	14	-	-	HYPH
cord-016187-58rqc0cg	196	15	mediated	mediate	VBN
cord-016187-58rqc0cg	196	16	resistance	resistance	NN
cord-016187-58rqc0cg	196	17	to	to	IN
cord-016187-58rqc0cg	196	18	these	these	DT
cord-016187-58rqc0cg	196	19	agents	agent	NNS
cord-016187-58rqc0cg	196	20	and	and	CC
cord-016187-58rqc0cg	196	21	other	other	JJ
cord-016187-58rqc0cg	196	22	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	196	23	agents	agent	NNS
cord-016187-58rqc0cg	196	24	[	[	-LRB-
cord-016187-58rqc0cg	196	25	47	47	CD
cord-016187-58rqc0cg	196	26	]	]	-RRB-
cord-016187-58rqc0cg	196	27	.	.	.
cord-016187-58rqc0cg	197	1	Transposons	transposon	NNS
cord-016187-58rqc0cg	197	2	are	be	VBP
cord-016187-58rqc0cg	197	3	specialized	specialized	JJ
cord-016187-58rqc0cg	197	4	sequences	sequence	NNS
cord-016187-58rqc0cg	197	5	of	of	IN
cord-016187-58rqc0cg	197	6	DNA	DNA	NNP
cord-016187-58rqc0cg	197	7	that	that	WDT
cord-016187-58rqc0cg	197	8	are	be	VBP
cord-016187-58rqc0cg	197	9	mobile	mobile	JJ
cord-016187-58rqc0cg	197	10	and	and	CC
cord-016187-58rqc0cg	197	11	can	can	MD
cord-016187-58rqc0cg	197	12	translocate	translocate	VB
cord-016187-58rqc0cg	197	13	as	as	IN
cord-016187-58rqc0cg	197	14	a	a	DT
cord-016187-58rqc0cg	197	15	unit	unit	NN
cord-016187-58rqc0cg	197	16	from	from	IN
cord-016187-58rqc0cg	197	17	one	one	CD
cord-016187-58rqc0cg	197	18	area	area	NN
cord-016187-58rqc0cg	197	19	of	of	IN
cord-016187-58rqc0cg	197	20	the	the	DT
cord-016187-58rqc0cg	197	21	bacterial	bacterial	JJ
cord-016187-58rqc0cg	197	22	chromosome	chromosome	NN
cord-016187-58rqc0cg	197	23	to	to	IN
cord-016187-58rqc0cg	197	24	another	another	DT
cord-016187-58rqc0cg	197	25	.	.	.
cord-016187-58rqc0cg	198	1	They	-PRON-	PRP
cord-016187-58rqc0cg	198	2	can	can	MD
cord-016187-58rqc0cg	198	3	also	also	RB
cord-016187-58rqc0cg	198	4	move	move	VB
cord-016187-58rqc0cg	198	5	back	back	RB
cord-016187-58rqc0cg	198	6	and	and	CC
cord-016187-58rqc0cg	198	7	forth	forth	RB
cord-016187-58rqc0cg	198	8	between	between	IN
cord-016187-58rqc0cg	198	9	the	the	DT
cord-016187-58rqc0cg	198	10	chromosome	chromosome	NN
cord-016187-58rqc0cg	198	11	and	and	CC
cord-016187-58rqc0cg	198	12	plasmid	plasmid	NN
cord-016187-58rqc0cg	198	13	or	or	CC
cord-016187-58rqc0cg	198	14	bacteriophage	bacteriophage	NN
cord-016187-58rqc0cg	198	15	DNA	dna	NN
cord-016187-58rqc0cg	198	16	.	.	.
cord-016187-58rqc0cg	199	1	Transposable	transposable	JJ
cord-016187-58rqc0cg	199	2	genetic	genetic	JJ
cord-016187-58rqc0cg	199	3	elements	element	NNS
cord-016187-58rqc0cg	199	4	possess	possess	VBP
cord-016187-58rqc0cg	199	5	a	a	DT
cord-016187-58rqc0cg	199	6	specialized	specialized	JJ
cord-016187-58rqc0cg	199	7	system	system	NN
cord-016187-58rqc0cg	199	8	of	of	IN
cord-016187-58rqc0cg	199	9	recombination	recombination	NN
cord-016187-58rqc0cg	199	10	that	that	WDT
cord-016187-58rqc0cg	199	11	is	be	VBZ
cord-016187-58rqc0cg	199	12	independent	independent	JJ
cord-016187-58rqc0cg	199	13	of	of	IN
cord-016187-58rqc0cg	199	14	the	the	DT
cord-016187-58rqc0cg	199	15	generalized	generalized	JJ
cord-016187-58rqc0cg	199	16	recombination	recombination	NN
cord-016187-58rqc0cg	199	17	system	system	NN
cord-016187-58rqc0cg	199	18	that	that	WDT
cord-016187-58rqc0cg	199	19	permits	permit	VBZ
cord-016187-58rqc0cg	199	20	recombination	recombination	NN
cord-016187-58rqc0cg	199	21	of	of	IN
cord-016187-58rqc0cg	199	22	largely	largely	RB
cord-016187-58rqc0cg	199	23	homologous	homologous	JJ
cord-016187-58rqc0cg	199	24	sequences	sequence	NNS
cord-016187-58rqc0cg	199	25	of	of	IN
cord-016187-58rqc0cg	199	26	DNA	dna	NN
cord-016187-58rqc0cg	199	27	by	by	IN
cord-016187-58rqc0cg	199	28	crossover	crossover	NN
cord-016187-58rqc0cg	199	29	events	event	NNS
cord-016187-58rqc0cg	199	30	(	(	-LRB-
cord-016187-58rqc0cg	199	31	the	the	DT
cord-016187-58rqc0cg	199	32	recA	recA	NNP
cord-016187-58rqc0cg	199	33	system	system	NN
cord-016187-58rqc0cg	199	34	of	of	IN
cord-016187-58rqc0cg	199	35	bacteria	bacteria	NNS
cord-016187-58rqc0cg	199	36	)	)	-RRB-
cord-016187-58rqc0cg	199	37	.	.	.
cord-016187-58rqc0cg	200	1	The	the	DT
cord-016187-58rqc0cg	200	2	recA	reca	JJ
cord-016187-58rqc0cg	200	3	-	-	HYPH
cord-016187-58rqc0cg	200	4	independent	independent	JJ
cord-016187-58rqc0cg	200	5	recombination	recombination	NN
cord-016187-58rqc0cg	200	6	system	system	NN
cord-016187-58rqc0cg	200	7	(	(	-LRB-
cord-016187-58rqc0cg	200	8	'	'	``
cord-016187-58rqc0cg	200	9	transposase	transposase	NNP
cord-016187-58rqc0cg	200	10	'	'	''
cord-016187-58rqc0cg	200	11	)	)	-RRB-
cord-016187-58rqc0cg	200	12	of	of	IN
cord-016187-58rqc0cg	200	13	transposable	transposable	JJ
cord-016187-58rqc0cg	200	14	elements	element	NNS
cord-016187-58rqc0cg	200	15	usually	usually	RB
cord-016187-58rqc0cg	200	16	occurs	occur	VBZ
cord-016187-58rqc0cg	200	17	in	in	IN
cord-016187-58rqc0cg	200	18	a	a	DT
cord-016187-58rqc0cg	200	19	random	random	JJ
cord-016187-58rqc0cg	200	20	fashion	fashion	NN
cord-016187-58rqc0cg	200	21	between	between	IN
cord-016187-58rqc0cg	200	22	non	non	JJ
cord-016187-58rqc0cg	200	23	-	-	JJ
cord-016187-58rqc0cg	200	24	homologous	homologous	JJ
cord-016187-58rqc0cg	200	25	DNA	dna	NN
cord-016187-58rqc0cg	200	26	sequences	sequence	NNS
cord-016187-58rqc0cg	200	27	and	and	CC
cord-016187-58rqc0cg	200	28	results	result	NNS
cord-016187-58rqc0cg	200	29	in	in	IN
cord-016187-58rqc0cg	200	30	whole	whole	JJ
cord-016187-58rqc0cg	200	31	-	-	HYPH
cord-016187-58rqc0cg	200	32	scale	scale	NN
cord-016187-58rqc0cg	200	33	modifi	modifi	JJ
cord-016187-58rqc0cg	200	34	cations	cation	NNS
cord-016187-58rqc0cg	200	35	of	of	IN
cord-016187-58rqc0cg	200	36	large	large	JJ
cord-016187-58rqc0cg	200	37	sequences	sequence	NNS
cord-016187-58rqc0cg	200	38	of	of	IN
cord-016187-58rqc0cg	200	39	DNA	DNA	NNP
cord-016187-58rqc0cg	200	40	as	as	IN
cord-016187-58rqc0cg	200	41	a	a	DT
cord-016187-58rqc0cg	200	42	single	single	JJ
cord-016187-58rqc0cg	200	43	event	event	NN
cord-016187-58rqc0cg	200	44	[	[	-LRB-
cord-016187-58rqc0cg	200	45	23	23	CD
cord-016187-58rqc0cg	200	46	]	]	-RRB-
cord-016187-58rqc0cg	200	47	.	.	.
cord-016187-58rqc0cg	201	1	There	there	EX
cord-016187-58rqc0cg	201	2	are	be	VBP
cord-016187-58rqc0cg	201	3	two	two	CD
cord-016187-58rqc0cg	201	4	types	type	NNS
cord-016187-58rqc0cg	201	5	of	of	IN
cord-016187-58rqc0cg	201	6	transposable	transposable	JJ
cord-016187-58rqc0cg	201	7	genetic	genetic	JJ
cord-016187-58rqc0cg	201	8	elements	element	NNS
cord-016187-58rqc0cg	201	9	,	,	,
cord-016187-58rqc0cg	201	10	transposons	transposon	NNS
cord-016187-58rqc0cg	201	11	and	and	CC
cord-016187-58rqc0cg	201	12	insertion	insertion	NN
cord-016187-58rqc0cg	201	13	sequences	sequence	NNS
cord-016187-58rqc0cg	201	14	.	.	.
cord-016187-58rqc0cg	202	1	These	these	DT
cord-016187-58rqc0cg	202	2	mobile	mobile	JJ
cord-016187-58rqc0cg	202	3	sequences	sequence	NNS
cord-016187-58rqc0cg	202	4	probably	probably	RB
cord-016187-58rqc0cg	202	5	play	play	VBP
cord-016187-58rqc0cg	202	6	an	an	DT
cord-016187-58rqc0cg	202	7	important	important	JJ
cord-016187-58rqc0cg	202	8	physiologic	physiologic	JJ
cord-016187-58rqc0cg	202	9	role	role	NN
cord-016187-58rqc0cg	202	10	in	in	IN
cord-016187-58rqc0cg	202	11	genetic	genetic	JJ
cord-016187-58rqc0cg	202	12	variation	variation	NN
cord-016187-58rqc0cg	202	13	and	and	CC
cord-016187-58rqc0cg	202	14	evolution	evolution	NN
cord-016187-58rqc0cg	202	15	in	in	IN
cord-016187-58rqc0cg	202	16	prokaryotic	prokaryotic	JJ
cord-016187-58rqc0cg	202	17	organisms	organism	NNS
cord-016187-58rqc0cg	202	18	.	.	.
cord-016187-58rqc0cg	203	1	Transposons	transposon	NNS
cord-016187-58rqc0cg	203	2	differ	differ	VBP
cord-016187-58rqc0cg	203	3	from	from	IN
cord-016187-58rqc0cg	203	4	insertion	insertion	NN
cord-016187-58rqc0cg	203	5	sequences	sequence	NNS
cord-016187-58rqc0cg	203	6	in	in	IN
cord-016187-58rqc0cg	203	7	that	that	IN
cord-016187-58rqc0cg	203	8	they	-PRON-	PRP
cord-016187-58rqc0cg	203	9	mediate	mediate	VBP
cord-016187-58rqc0cg	203	10	a	a	DT
cord-016187-58rqc0cg	203	11	recognizable	recognizable	JJ
cord-016187-58rqc0cg	203	12	phenotypic	phenotypic	NN
cord-016187-58rqc0cg	203	13	marker	marker	NN
cord-016187-58rqc0cg	203	14	such	such	JJ
cord-016187-58rqc0cg	203	15	as	as	IN
cord-016187-58rqc0cg	203	16	an	an	DT
cord-016187-58rqc0cg	203	17	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	203	18	-	-	HYPH
cord-016187-58rqc0cg	203	19	resistance	resistance	NN
cord-016187-58rqc0cg	203	20	trait	trait	NN
cord-016187-58rqc0cg	203	21	.	.	.
cord-016187-58rqc0cg	204	1	Either	either	DT
cord-016187-58rqc0cg	204	2	element	element	NN
cord-016187-58rqc0cg	204	3	can	can	MD
cord-016187-58rqc0cg	204	4	translocate	translocate	VB
cord-016187-58rqc0cg	204	5	as	as	IN
cord-016187-58rqc0cg	204	6	an	an	DT
cord-016187-58rqc0cg	204	7	independent	independent	JJ
cord-016187-58rqc0cg	204	8	unit	unit	NN
cord-016187-58rqc0cg	204	9	.	.	.
cord-016187-58rqc0cg	205	1	Both	both	DT
cord-016187-58rqc0cg	205	2	elements	element	NNS
cord-016187-58rqc0cg	205	3	are	be	VBP
cord-016187-58rqc0cg	205	4	fl	fl	NNP
cord-016187-58rqc0cg	205	5	anked	anke	VBN
cord-016187-58rqc0cg	205	6	on	on	IN
cord-016187-58rqc0cg	205	7	either	either	DT
cord-016187-58rqc0cg	205	8	end	end	NN
cord-016187-58rqc0cg	205	9	by	by	IN
cord-016187-58rqc0cg	205	10	short	short	JJ
cord-016187-58rqc0cg	205	11	identical	identical	JJ
cord-016187-58rqc0cg	205	12	sequences	sequence	NNS
cord-016187-58rqc0cg	205	13	of	of	IN
cord-016187-58rqc0cg	205	14	DNA	dna	NN
cord-016187-58rqc0cg	205	15	in	in	IN
cord-016187-58rqc0cg	205	16	reverse	reverse	JJ
cord-016187-58rqc0cg	205	17	order	order	NN
cord-016187-58rqc0cg	205	18	(	(	-LRB-
cord-016187-58rqc0cg	205	19	inverted	invert	VBN
cord-016187-58rqc0cg	205	20	repeats	repeat	VBZ
cord-016187-58rqc0cg	205	21	)	)	-RRB-
cord-016187-58rqc0cg	205	22	.	.	.
cord-016187-58rqc0cg	206	1	These	these	DT
cord-016187-58rqc0cg	206	2	inverted	invert	VBN
cord-016187-58rqc0cg	206	3	-	-	HYPH
cord-016187-58rqc0cg	206	4	repeat	repeat	NN
cord-016187-58rqc0cg	206	5	DNA	dna	NN
cord-016187-58rqc0cg	206	6	termini	terminus	NNS
cord-016187-58rqc0cg	206	7	are	be	VBP
cord-016187-58rqc0cg	206	8	essential	essential	JJ
cord-016187-58rqc0cg	206	9	to	to	IN
cord-016187-58rqc0cg	206	10	the	the	DT
cord-016187-58rqc0cg	206	11	transposition	transposition	NN
cord-016187-58rqc0cg	206	12	process	process	NN
cord-016187-58rqc0cg	206	13	.	.	.
cord-016187-58rqc0cg	207	1	Transposons	transposon	NNS
cord-016187-58rqc0cg	207	2	and	and	CC
cord-016187-58rqc0cg	207	3	insertion	insertion	NN
cord-016187-58rqc0cg	207	4	sequences	sequence	NNS
cord-016187-58rqc0cg	207	5	must	must	MD
cord-016187-58rqc0cg	207	6	be	be	VB
cord-016187-58rqc0cg	207	7	physically	physically	RB
cord-016187-58rqc0cg	207	8	integrated	integrate	VBN
cord-016187-58rqc0cg	207	9	with	with	IN
cord-016187-58rqc0cg	207	10	chromosome	chromosome	NN
cord-016187-58rqc0cg	207	11	,	,	,
cord-016187-58rqc0cg	207	12	bacteriophage	bacteriophage	NN
cord-016187-58rqc0cg	207	13	,	,	,
cord-016187-58rqc0cg	207	14	or	or	CC
cord-016187-58rqc0cg	207	15	plasmid	plasmid	NN
cord-016187-58rqc0cg	207	16	DNA	dna	NN
cord-016187-58rqc0cg	207	17	in	in	IN
cord-016187-58rqc0cg	207	18	order	order	NN
cord-016187-58rqc0cg	207	19	to	to	TO
cord-016187-58rqc0cg	207	20	be	be	VB
cord-016187-58rqc0cg	207	21	replicated	replicate	VBN
cord-016187-58rqc0cg	207	22	and	and	CC
cord-016187-58rqc0cg	207	23	maintained	maintain	VBN
cord-016187-58rqc0cg	207	24	in	in	IN
cord-016187-58rqc0cg	207	25	a	a	DT
cord-016187-58rqc0cg	207	26	bacterial	bacterial	JJ
cord-016187-58rqc0cg	207	27	population	population	NN
cord-016187-58rqc0cg	207	28	.	.	.
cord-016187-58rqc0cg	208	1	Some	some	DT
cord-016187-58rqc0cg	208	2	transposons	transposon	NNS
cord-016187-58rqc0cg	208	3	have	have	VBP
cord-016187-58rqc0cg	208	4	the	the	DT
cord-016187-58rqc0cg	208	5	capability	capability	NN
cord-016187-58rqc0cg	208	6	to	to	TO
cord-016187-58rqc0cg	208	7	move	move	VB
cord-016187-58rqc0cg	208	8	from	from	IN
cord-016187-58rqc0cg	208	9	one	one	CD
cord-016187-58rqc0cg	208	10	bacterium	bacterium	NN
cord-016187-58rqc0cg	208	11	to	to	IN
cord-016187-58rqc0cg	208	12	another	another	DT
cord-016187-58rqc0cg	208	13	without	without	IN
cord-016187-58rqc0cg	208	14	being	be	VBG
cord-016187-58rqc0cg	208	15	transferred	transfer	VBN
cord-016187-58rqc0cg	208	16	within	within	IN
cord-016187-58rqc0cg	208	17	a	a	DT
cord-016187-58rqc0cg	208	18	plasmid	plasmid	NN
cord-016187-58rqc0cg	208	19	or	or	CC
cord-016187-58rqc0cg	208	20	bacteriophage	bacteriophage	NN
cord-016187-58rqc0cg	208	21	.	.	.
cord-016187-58rqc0cg	209	1	These	these	DT
cord-016187-58rqc0cg	209	2	conjugative	conjugative	JJ
cord-016187-58rqc0cg	209	3	transposons	transposon	NNS
cord-016187-58rqc0cg	209	4	are	be	VBP
cord-016187-58rqc0cg	209	5	found	find	VBN
cord-016187-58rqc0cg	209	6	primarily	primarily	RB
cord-016187-58rqc0cg	209	7	in	in	IN
cord-016187-58rqc0cg	209	8	aerobic	aerobic	JJ
cord-016187-58rqc0cg	209	9	and	and	CC
cord-016187-58rqc0cg	209	10	anaerobic	anaerobic	JJ
cord-016187-58rqc0cg	209	11	Gram	gram	NN
cord-016187-58rqc0cg	209	12	-	-	HYPH
cord-016187-58rqc0cg	209	13	positive	positive	JJ
cord-016187-58rqc0cg	209	14	organisms	organism	NNS
cord-016187-58rqc0cg	209	15	and	and	CC
cord-016187-58rqc0cg	209	16	can	can	MD
cord-016187-58rqc0cg	209	17	rapidly	rapidly	RB
cord-016187-58rqc0cg	209	18	and	and	CC
cord-016187-58rqc0cg	209	19	effi	effi	NNP
cord-016187-58rqc0cg	209	20	ciently	ciently	NNP
cord-016187-58rqc0cg	209	21	spread	spread	VBD
cord-016187-58rqc0cg	209	22	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	209	23	resistance	resistance	NN
cord-016187-58rqc0cg	209	24	genes	gene	NNS
cord-016187-58rqc0cg	209	25	[	[	-LRB-
cord-016187-58rqc0cg	209	26	30	30	CD
cord-016187-58rqc0cg	209	27	,	,	,
cord-016187-58rqc0cg	209	28	48	48	CD
cord-016187-58rqc0cg	209	29	]	]	-RRB-
cord-016187-58rqc0cg	209	30	.	.	.
cord-016187-58rqc0cg	210	1	Transposition	transposition	NN
cord-016187-58rqc0cg	210	2	,	,	,
cord-016187-58rqc0cg	210	3	like	like	IN
cord-016187-58rqc0cg	210	4	point	point	NN
cord-016187-58rqc0cg	210	5	mutation	mutation	NN
cord-016187-58rqc0cg	210	6	,	,	,
cord-016187-58rqc0cg	210	7	is	be	VBZ
cord-016187-58rqc0cg	210	8	a	a	DT
cord-016187-58rqc0cg	210	9	continuous	continuous	JJ
cord-016187-58rqc0cg	210	10	and	and	CC
cord-016187-58rqc0cg	210	11	ongoing	ongoing	JJ
cord-016187-58rqc0cg	210	12	process	process	NN
cord-016187-58rqc0cg	210	13	in	in	IN
cord-016187-58rqc0cg	210	14	bacterial	bacterial	JJ
cord-016187-58rqc0cg	210	15	populations	population	NNS
cord-016187-58rqc0cg	210	16	.	.	.
cord-016187-58rqc0cg	211	1	Transposons	transposon	NNS
cord-016187-58rqc0cg	211	2	are	be	VBP
cord-016187-58rqc0cg	211	3	also	also	RB
cord-016187-58rqc0cg	211	4	essential	essential	JJ
cord-016187-58rqc0cg	211	5	in	in	IN
cord-016187-58rqc0cg	211	6	the	the	DT
cord-016187-58rqc0cg	211	7	evolution	evolution	NN
cord-016187-58rqc0cg	211	8	of	of	IN
cord-016187-58rqc0cg	211	9	R	r	NN
cord-016187-58rqc0cg	211	10	plasmids	plasmid	NNS
cord-016187-58rqc0cg	211	11	that	that	WDT
cord-016187-58rqc0cg	211	12	contain	contain	VBP
cord-016187-58rqc0cg	211	13	multiple	multiple	JJ
cord-016187-58rqc0cg	211	14	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	211	15	-	-	HYPH
cord-016187-58rqc0cg	211	16	resistance	resistance	NN
cord-016187-58rqc0cg	211	17	determinants	determinant	NNS
cord-016187-58rqc0cg	211	18	[	[	-LRB-
cord-016187-58rqc0cg	211	19	47	47	CD
cord-016187-58rqc0cg	211	20	]	]	-RRB-
cord-016187-58rqc0cg	211	21	.	.	.
cord-016187-58rqc0cg	212	1	High	high	JJ
cord-016187-58rqc0cg	212	2	-	-	HYPH
cord-016187-58rqc0cg	212	3	level	level	NN
cord-016187-58rqc0cg	212	4	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	212	5	resistance	resistance	NN
cord-016187-58rqc0cg	212	6	(	(	-LRB-
cord-016187-58rqc0cg	212	7	vanA	vanA	NNP
cord-016187-58rqc0cg	212	8	)	)	-RRB-
cord-016187-58rqc0cg	212	9	in	in	IN
cord-016187-58rqc0cg	212	10	enterococci	enterococci	NNP
cord-016187-58rqc0cg	212	11	is	be	VBZ
cord-016187-58rqc0cg	212	12	mediated	mediate	VBN
cord-016187-58rqc0cg	212	13	by	by	IN
cord-016187-58rqc0cg	212	14	a	a	DT
cord-016187-58rqc0cg	212	15	composite	composite	JJ
cord-016187-58rqc0cg	212	16	transposon	transposon	NN
cord-016187-58rqc0cg	212	17	that	that	WDT
cord-016187-58rqc0cg	212	18	encodes	encode	VBZ
cord-016187-58rqc0cg	212	19	a	a	DT
cord-016187-58rqc0cg	212	20	series	series	NN
cord-016187-58rqc0cg	212	21	of	of	IN
cord-016187-58rqc0cg	212	22	genes	gene	NNS
cord-016187-58rqc0cg	212	23	needed	need	VBN
cord-016187-58rqc0cg	212	24	to	to	TO
cord-016187-58rqc0cg	212	25	express	express	VB
cord-016187-58rqc0cg	212	26	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	212	27	resistance	resistance	NN
cord-016187-58rqc0cg	212	28	[	[	-LRB-
cord-016187-58rqc0cg	212	29	38	38	CD
cord-016187-58rqc0cg	212	30	]	]	-RRB-
cord-016187-58rqc0cg	212	31	.	.	.
cord-016187-58rqc0cg	213	1	Single	single	JJ
cord-016187-58rqc0cg	213	2	transposons	transposon	NNS
cord-016187-58rqc0cg	213	3	may	may	MD
cord-016187-58rqc0cg	213	4	encode	encode	VB
cord-016187-58rqc0cg	213	5	multiple	multiple	JJ
cord-016187-58rqc0cg	213	6	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	213	7	-	-	HYPH
cord-016187-58rqc0cg	213	8	resistance	resistance	NN
cord-016187-58rqc0cg	213	9	determinants	determinant	NNS
cord-016187-58rqc0cg	213	10	within	within	IN
cord-016187-58rqc0cg	213	11	their	-PRON-	PRP$
cord-016187-58rqc0cg	213	12	inverted	invert	VBN
cord-016187-58rqc0cg	213	13	-	-	HYPH
cord-016187-58rqc0cg	213	14	repeat	repeat	NN
cord-016187-58rqc0cg	213	15	termini	terminus	NNS
cord-016187-58rqc0cg	213	16	as	as	RB
cord-016187-58rqc0cg	213	17	well	well	RB
cord-016187-58rqc0cg	213	18	[	[	-LRB-
cord-016187-58rqc0cg	213	19	23	23	CD
cord-016187-58rqc0cg	213	20	]	]	-RRB-
cord-016187-58rqc0cg	213	21	.	.	.
cord-016187-58rqc0cg	214	1	Genetic	genetic	JJ
cord-016187-58rqc0cg	214	2	exchange	exchange	NN
cord-016187-58rqc0cg	214	3	of	of	IN
cord-016187-58rqc0cg	214	4	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	214	5	-	-	HYPH
cord-016187-58rqc0cg	214	6	resistance	resistance	NN
cord-016187-58rqc0cg	214	7	genes	gene	NNS
cord-016187-58rqc0cg	214	8	occurs	occur	VBZ
cord-016187-58rqc0cg	214	9	between	between	IN
cord-016187-58rqc0cg	214	10	bacteria	bacteria	NNS
cord-016187-58rqc0cg	214	11	of	of	IN
cord-016187-58rqc0cg	214	12	widely	widely	RB
cord-016187-58rqc0cg	214	13	disparate	disparate	JJ
cord-016187-58rqc0cg	214	14	species	specie	NNS
cord-016187-58rqc0cg	214	15	and	and	CC
cord-016187-58rqc0cg	214	16	different	different	JJ
cord-016187-58rqc0cg	214	17	genera	genus	NNS
cord-016187-58rqc0cg	214	18	.	.	.
cord-016187-58rqc0cg	215	1	Identical	identical	JJ
cord-016187-58rqc0cg	215	2	aminoglycoside	aminoglycoside	JJ
cord-016187-58rqc0cg	215	3	-	-	HYPH
cord-016187-58rqc0cg	215	4	resistance	resistance	NN
cord-016187-58rqc0cg	215	5	genes	gene	NNS
cord-016187-58rqc0cg	215	6	can	can	MD
cord-016187-58rqc0cg	215	7	spread	spread	VB
cord-016187-58rqc0cg	215	8	between	between	IN
cord-016187-58rqc0cg	215	9	Gram	gram	NN
cord-016187-58rqc0cg	215	10	-	-	HYPH
cord-016187-58rqc0cg	215	11	negative	negative	JJ
cord-016187-58rqc0cg	215	12	and	and	CC
cord-016187-58rqc0cg	215	13	Gram	gram	NN
cord-016187-58rqc0cg	215	14	-	-	HYPH
cord-016187-58rqc0cg	215	15	positive	positive	JJ
cord-016187-58rqc0cg	215	16	bacteria	bacteria	NNS
cord-016187-58rqc0cg	215	17	and	and	CC
cord-016187-58rqc0cg	215	18	between	between	IN
cord-016187-58rqc0cg	215	19	aerobic	aerobic	JJ
cord-016187-58rqc0cg	215	20	and	and	CC
cord-016187-58rqc0cg	215	21	anaerobic	anaerobic	JJ
cord-016187-58rqc0cg	215	22	bacteria	bacteria	NNS
cord-016187-58rqc0cg	215	23	[	[	-LRB-
cord-016187-58rqc0cg	215	24	49	49	CD
cord-016187-58rqc0cg	215	25	]	]	-RRB-
cord-016187-58rqc0cg	215	26	.	.	.
cord-016187-58rqc0cg	216	1	Given	give	VBN
cord-016187-58rqc0cg	216	2	the	the	DT
cord-016187-58rqc0cg	216	3	highly	highly	RB
cord-016187-58rqc0cg	216	4	variable	variable	JJ
cord-016187-58rqc0cg	216	5	environmental	environmental	JJ
cord-016187-58rqc0cg	216	6	selection	selection	NN
cord-016187-58rqc0cg	216	7	pressures	pressure	NNS
cord-016187-58rqc0cg	216	8	created	create	VBN
cord-016187-58rqc0cg	216	9	by	by	IN
cord-016187-58rqc0cg	216	10	a	a	DT
cord-016187-58rqc0cg	216	11	wide	wide	JJ
cord-016187-58rqc0cg	216	12	variety	variety	NN
cord-016187-58rqc0cg	216	13	of	of	IN
cord-016187-58rqc0cg	216	14	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	216	15	and	and	CC
cord-016187-58rqc0cg	216	16	the	the	DT
cord-016187-58rqc0cg	216	17	plasticity	plasticity	NN
cord-016187-58rqc0cg	216	18	of	of	IN
cord-016187-58rqc0cg	216	19	bacterial	bacterial	JJ
cord-016187-58rqc0cg	216	20	genomes	genome	NNS
cord-016187-58rqc0cg	216	21	,	,	,
cord-016187-58rqc0cg	216	22	the	the	DT
cord-016187-58rqc0cg	216	23	ongoing	ongoing	JJ
cord-016187-58rqc0cg	216	24	evolution	evolution	NN
cord-016187-58rqc0cg	216	25	of	of	IN
cord-016187-58rqc0cg	216	26	multi	multi	JJ
cord-016187-58rqc0cg	216	27	-	-	JJ
cord-016187-58rqc0cg	216	28	drug	drug	JJ
cord-016187-58rqc0cg	216	29	resistant	resistant	JJ
cord-016187-58rqc0cg	216	30	bacterial	bacterial	JJ
cord-016187-58rqc0cg	216	31	organisms	organism	NNS
cord-016187-58rqc0cg	216	32	is	be	VBZ
cord-016187-58rqc0cg	216	33	probably	probably	RB
cord-016187-58rqc0cg	216	34	inevitable	inevitable	JJ
cord-016187-58rqc0cg	216	35	[	[	-LRB-
cord-016187-58rqc0cg	216	36	23	23	CD
cord-016187-58rqc0cg	216	37	]	]	-RRB-
cord-016187-58rqc0cg	216	38	.	.	.
cord-016187-58rqc0cg	217	1	The	the	DT
cord-016187-58rqc0cg	217	2	structural	structural	JJ
cord-016187-58rqc0cg	217	3	genes	gene	NNS
cord-016187-58rqc0cg	217	4	that	that	WDT
cord-016187-58rqc0cg	217	5	mediate	mediate	VBP
cord-016187-58rqc0cg	217	6	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	217	7	resistance	resistance	NN
cord-016187-58rqc0cg	217	8	are	be	VBP
cord-016187-58rqc0cg	217	9	often	often	RB
cord-016187-58rqc0cg	217	10	closely	closely	RB
cord-016187-58rqc0cg	217	11	linked	link	VBN
cord-016187-58rqc0cg	217	12	and	and	CC
cord-016187-58rqc0cg	217	13	may	may	MD
cord-016187-58rqc0cg	217	14	exist	exist	VB
cord-016187-58rqc0cg	217	15	in	in	IN
cord-016187-58rqc0cg	217	16	tandem	tandem	NN
cord-016187-58rqc0cg	217	17	along	along	IN
cord-016187-58rqc0cg	217	18	the	the	DT
cord-016187-58rqc0cg	217	19	bacterial	bacterial	JJ
cord-016187-58rqc0cg	217	20	chromosome	chromosome	NN
cord-016187-58rqc0cg	217	21	or	or	CC
cord-016187-58rqc0cg	217	22	plasmid	plasmid	NN
cord-016187-58rqc0cg	217	23	.	.	.
cord-016187-58rqc0cg	218	1	Genetic	genetic	JJ
cord-016187-58rqc0cg	218	2	analysis	analysis	NN
cord-016187-58rqc0cg	218	3	of	of	IN
cord-016187-58rqc0cg	218	4	sequences	sequence	NNS
cord-016187-58rqc0cg	218	5	of	of	IN
cord-016187-58rqc0cg	218	6	DNA	dna	NN
cord-016187-58rqc0cg	218	7	adjacent	adjacent	JJ
cord-016187-58rqc0cg	218	8	to	to	IN
cord-016187-58rqc0cg	218	9	resistance	resistance	NN
cord-016187-58rqc0cg	218	10	genes	gene	NNS
cord-016187-58rqc0cg	218	11	has	have	VBZ
cord-016187-58rqc0cg	218	12	identifi	identifi	VBN
cord-016187-58rqc0cg	218	13	ed	ed	NNP
cord-016187-58rqc0cg	218	14	unique	unique	JJ
cord-016187-58rqc0cg	218	15	integration	integration	NN
cord-016187-58rqc0cg	218	16	units	unit	NNS
cord-016187-58rqc0cg	218	17	near	near	IN
cord-016187-58rqc0cg	218	18	promoter	promoter	NN
cord-016187-58rqc0cg	218	19	sites	site	NNS
cord-016187-58rqc0cg	218	20	[	[	-LRB-
cord-016187-58rqc0cg	218	21	50	50	CD
cord-016187-58rqc0cg	218	22	]	]	-RRB-
cord-016187-58rqc0cg	218	23	.	.	.
cord-016187-58rqc0cg	219	1	These	these	DT
cord-016187-58rqc0cg	219	2	integration	integration	NN
cord-016187-58rqc0cg	219	3	regions	region	NNS
cord-016187-58rqc0cg	219	4	are	be	VBP
cord-016187-58rqc0cg	219	5	known	know	VBN
cord-016187-58rqc0cg	219	6	as	as	IN
cord-016187-58rqc0cg	219	7	integrons	integron	NNS
cord-016187-58rqc0cg	219	8	,	,	,
cord-016187-58rqc0cg	219	9	and	and	CC
cord-016187-58rqc0cg	219	10	they	-PRON-	PRP
cord-016187-58rqc0cg	219	11	function	function	VBP
cord-016187-58rqc0cg	219	12	as	as	IN
cord-016187-58rqc0cg	219	13	convenient	convenient	JJ
cord-016187-58rqc0cg	219	14	recombinational	recombinational	JJ
cord-016187-58rqc0cg	219	15	'	'	POS
cord-016187-58rqc0cg	219	16	hot	hot	JJ
cord-016187-58rqc0cg	219	17	spots	spot	NNS
cord-016187-58rqc0cg	219	18	'	'	POS
cord-016187-58rqc0cg	219	19	for	for	IN
cord-016187-58rqc0cg	219	20	site	site	NN
cord-016187-58rqc0cg	219	21	-	-	HYPH
cord-016187-58rqc0cg	219	22	specifi	specifi	NN
cord-016187-58rqc0cg	219	23	c	c	NN
cord-016187-58rqc0cg	219	24	recombination	recombination	NN
cord-016187-58rqc0cg	219	25	events	event	NNS
cord-016187-58rqc0cg	219	26	between	between	IN
cord-016187-58rqc0cg	219	27	largely	largely	RB
cord-016187-58rqc0cg	219	28	non	non	JJ
cord-016187-58rqc0cg	219	29	-	-	JJ
cord-016187-58rqc0cg	219	30	homologous	homologous	JJ
cord-016187-58rqc0cg	219	31	sequences	sequence	NNS
cord-016187-58rqc0cg	219	32	of	of	IN
cord-016187-58rqc0cg	219	33	DNA	DNA	NNP
cord-016187-58rqc0cg	219	34	.	.	.
cord-016187-58rqc0cg	220	1	The	the	DT
cord-016187-58rqc0cg	220	2	integron	integron	NN
cord-016187-58rqc0cg	220	3	provides	provide	VBZ
cord-016187-58rqc0cg	220	4	its	-PRON-	PRP$
cord-016187-58rqc0cg	220	5	own	own	JJ
cord-016187-58rqc0cg	220	6	integrase	integrase	NN
cord-016187-58rqc0cg	220	7	function	function	NN
cord-016187-58rqc0cg	220	8	[	[	-LRB-
cord-016187-58rqc0cg	220	9	94	94	CD
cord-016187-58rqc0cg	220	10	]	]	-RRB-
cord-016187-58rqc0cg	220	11	with	with	IN
cord-016187-58rqc0cg	220	12	a	a	DT
cord-016187-58rqc0cg	220	13	common	common	JJ
cord-016187-58rqc0cg	220	14	attachment	attachment	NN
cord-016187-58rqc0cg	220	15	and	and	CC
cord-016187-58rqc0cg	220	16	integration	integration	NN
cord-016187-58rqc0cg	220	17	site	site	NN
cord-016187-58rqc0cg	220	18	for	for	IN
cord-016187-58rqc0cg	220	19	acquisition	acquisition	NN
cord-016187-58rqc0cg	220	20	of	of	IN
cord-016187-58rqc0cg	220	21	foreign	foreign	JJ
cord-016187-58rqc0cg	220	22	DNA	dna	NN
cord-016187-58rqc0cg	220	23	sequences	sequence	NNS
cord-016187-58rqc0cg	220	24	.	.	.
cord-016187-58rqc0cg	221	1	Integrons	integron	NNS
cord-016187-58rqc0cg	221	2	are	be	VBP
cord-016187-58rqc0cg	221	3	widespread	widespread	JJ
cord-016187-58rqc0cg	221	4	in	in	IN
cord-016187-58rqc0cg	221	5	bacterial	bacterial	JJ
cord-016187-58rqc0cg	221	6	populations	population	NNS
cord-016187-58rqc0cg	221	7	and	and	CC
cord-016187-58rqc0cg	221	8	provide	provide	VB
cord-016187-58rqc0cg	221	9	a	a	DT
cord-016187-58rqc0cg	221	10	convenient	convenient	JJ
cord-016187-58rqc0cg	221	11	site	site	NN
cord-016187-58rqc0cg	221	12	for	for	IN
cord-016187-58rqc0cg	221	13	insertion	insertion	NN
cord-016187-58rqc0cg	221	14	of	of	IN
cord-016187-58rqc0cg	221	15	multiple	multiple	JJ
cord-016187-58rqc0cg	221	16	different	different	JJ
cord-016187-58rqc0cg	221	17	resistance	resistance	NN
cord-016187-58rqc0cg	221	18	genes	gene	NNS
cord-016187-58rqc0cg	221	19	from	from	IN
cord-016187-58rqc0cg	221	20	foreign	foreign	JJ
cord-016187-58rqc0cg	221	21	DNA	dna	NN
cord-016187-58rqc0cg	221	22	sources	source	NNS
cord-016187-58rqc0cg	221	23	.	.	.
cord-016187-58rqc0cg	222	1	There	there	EX
cord-016187-58rqc0cg	222	2	are	be	VBP
cord-016187-58rqc0cg	222	3	four	four	CD
cord-016187-58rqc0cg	222	4	classes	class	NNS
cord-016187-58rqc0cg	222	5	of	of	IN
cord-016187-58rqc0cg	222	6	integrons	integron	NNS
cord-016187-58rqc0cg	222	7	with	with	IN
cord-016187-58rqc0cg	222	8	type	type	NN
cord-016187-58rqc0cg	223	1	I	-PRON-	PRP
cord-016187-58rqc0cg	223	2	integrons	integrons	VBP
cord-016187-58rqc0cg	223	3	being	be	VBG
cord-016187-58rqc0cg	223	4	the	the	DT
cord-016187-58rqc0cg	223	5	most	most	RBS
cord-016187-58rqc0cg	223	6	common	common	JJ
cord-016187-58rqc0cg	223	7	in	in	IN
cord-016187-58rqc0cg	223	8	pathogenic	pathogenic	JJ
cord-016187-58rqc0cg	223	9	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	223	10	[	[	-LRB-
cord-016187-58rqc0cg	223	11	23	23	CD
cord-016187-58rqc0cg	223	12	]	]	-RRB-
cord-016187-58rqc0cg	223	13	.	.	.
cord-016187-58rqc0cg	224	1	Integrons	Integrons	NNP
cord-016187-58rqc0cg	224	2	also	also	RB
cord-016187-58rqc0cg	224	3	serve	serve	VBP
cord-016187-58rqc0cg	224	4	as	as	IN
cord-016187-58rqc0cg	224	5	effi	effi	NNP
cord-016187-58rqc0cg	224	6	cient	cient	NNP
cord-016187-58rqc0cg	224	7	expression	expression	NN
cord-016187-58rqc0cg	224	8	cassettes	cassette	NNS
cord-016187-58rqc0cg	224	9	for	for	IN
cord-016187-58rqc0cg	224	10	resistance	resistance	NN
cord-016187-58rqc0cg	224	11	genes	gene	NNS
cord-016187-58rqc0cg	224	12	.	.	.
cord-016187-58rqc0cg	225	1	Integrons	Integrons	NNPS
cord-016187-58rqc0cg	225	2	possess	possess	VBP
cord-016187-58rqc0cg	225	3	a	a	DT
cord-016187-58rqc0cg	225	4	promoter	promoter	NN
cord-016187-58rqc0cg	225	5	site	site	NN
cord-016187-58rqc0cg	225	6	in	in	IN
cord-016187-58rqc0cg	225	7	close	close	JJ
cord-016187-58rqc0cg	225	8	proximity	proximity	NN
cord-016187-58rqc0cg	225	9	to	to	IN
cord-016187-58rqc0cg	225	10	the	the	DT
cord-016187-58rqc0cg	225	11	5'end	5'end	CD
cord-016187-58rqc0cg	225	12	of	of	IN
cord-016187-58rqc0cg	225	13	the	the	DT
cord-016187-58rqc0cg	225	14	newly	newly	RB
cord-016187-58rqc0cg	225	15	inserted	insert	VBN
cord-016187-58rqc0cg	225	16	DNA	dna	NN
cord-016187-58rqc0cg	225	17	sequence	sequence	NN
cord-016187-58rqc0cg	225	18	.	.	.
cord-016187-58rqc0cg	226	1	Numerous	numerous	JJ
cord-016187-58rqc0cg	226	2	clusters	cluster	NNS
cord-016187-58rqc0cg	226	3	of	of	IN
cord-016187-58rqc0cg	226	4	different	different	JJ
cord-016187-58rqc0cg	226	5	resistance	resistance	NN
cord-016187-58rqc0cg	226	6	genes	gene	NNS
cord-016187-58rqc0cg	226	7	have	have	VBP
cord-016187-58rqc0cg	226	8	been	be	VBN
cord-016187-58rqc0cg	226	9	linked	link	VBN
cord-016187-58rqc0cg	226	10	into	into	IN
cord-016187-58rqc0cg	226	11	integrons	integron	NNS
cord-016187-58rqc0cg	226	12	through	through	IN
cord-016187-58rqc0cg	226	13	specifi	specifi	NNP
cord-016187-58rqc0cg	226	14	c	c	NN
cord-016187-58rqc0cg	226	15	insertion	insertion	NN
cord-016187-58rqc0cg	226	16	sites	site	NNS
cord-016187-58rqc0cg	226	17	.	.	.
cord-016187-58rqc0cg	227	1	Integrons	Integrons	NNP
cord-016187-58rqc0cg	227	2	may	may	MD
cord-016187-58rqc0cg	227	3	have	have	VB
cord-016187-58rqc0cg	227	4	as	as	RB
cord-016187-58rqc0cg	227	5	many	many	JJ
cord-016187-58rqc0cg	227	6	as	as	IN
cord-016187-58rqc0cg	227	7	fi	fi	NNP
cord-016187-58rqc0cg	227	8	ve	ve	VBD
cord-016187-58rqc0cg	227	9	resistance	resistance	NN
cord-016187-58rqc0cg	227	10	genes	gene	NNS
cord-016187-58rqc0cg	227	11	linked	link	VBN
cord-016187-58rqc0cg	227	12	in	in	IN
cord-016187-58rqc0cg	227	13	sequence	sequence	NN
cord-016187-58rqc0cg	227	14	and	and	CC
cord-016187-58rqc0cg	227	15	fl	fl	NNP
cord-016187-58rqc0cg	227	16	anked	anked	NNP
cord-016187-58rqc0cg	227	17	between	between	IN
cord-016187-58rqc0cg	227	18	specifi	specifi	NNP
cord-016187-58rqc0cg	227	19	c	c	NNP
cord-016187-58rqc0cg	227	20	59	59	CD
cord-016187-58rqc0cg	227	21	base	base	NN
cord-016187-58rqc0cg	227	22	-	-	HYPH
cord-016187-58rqc0cg	227	23	pair	pair	NN
cord-016187-58rqc0cg	227	24	spacer	spacer	NN
cord-016187-58rqc0cg	227	25	units	unit	NNS
cord-016187-58rqc0cg	227	26	[	[	-LRB-
cord-016187-58rqc0cg	227	27	50	50	CD
cord-016187-58rqc0cg	227	28	,	,	,
cord-016187-58rqc0cg	227	29	51	51	CD
cord-016187-58rqc0cg	227	30	]	]	-RRB-
cord-016187-58rqc0cg	227	31	.	.	.
cord-016187-58rqc0cg	228	1	Integron	Integron	NNP
cord-016187-58rqc0cg	228	2	-	-	HYPH
cord-016187-58rqc0cg	228	3	mediated	mediate	VBN
cord-016187-58rqc0cg	228	4	multiple	multiple	JJ
cord-016187-58rqc0cg	228	5	resistance	resistance	NN
cord-016187-58rqc0cg	228	6	gene	gene	NN
cord-016187-58rqc0cg	228	7	cassettes	cassette	NNS
cord-016187-58rqc0cg	228	8	have	have	VBP
cord-016187-58rqc0cg	228	9	been	be	VBN
cord-016187-58rqc0cg	228	10	fl	fl	NNP
cord-016187-58rqc0cg	228	11	anked	anke	VBN
cord-016187-58rqc0cg	228	12	by	by	IN
cord-016187-58rqc0cg	228	13	transposons	transposon	NNS
cord-016187-58rqc0cg	228	14	,	,	,
cord-016187-58rqc0cg	228	15	mobilized	mobilize	VBD
cord-016187-58rqc0cg	228	16	to	to	IN
cord-016187-58rqc0cg	228	17	plasmids	plasmid	NNS
cord-016187-58rqc0cg	228	18	,	,	,
cord-016187-58rqc0cg	228	19	and	and	CC
cord-016187-58rqc0cg	228	20	then	then	RB
cord-016187-58rqc0cg	228	21	transferred	transfer	VBN
cord-016187-58rqc0cg	228	22	between	between	IN
cord-016187-58rqc0cg	228	23	bacterial	bacterial	JJ
cord-016187-58rqc0cg	228	24	species	specie	NNS
cord-016187-58rqc0cg	228	25	by	by	IN
cord-016187-58rqc0cg	228	26	conjugation	conjugation	NN
cord-016187-58rqc0cg	228	27	.	.	.
cord-016187-58rqc0cg	229	1	By	by	IN
cord-016187-58rqc0cg	229	2	these	these	DT
cord-016187-58rqc0cg	229	3	systems	system	NNS
cord-016187-58rqc0cg	229	4	of	of	IN
cord-016187-58rqc0cg	229	5	genetic	genetic	JJ
cord-016187-58rqc0cg	229	6	exchange	exchange	NN
cord-016187-58rqc0cg	229	7	,	,	,
cord-016187-58rqc0cg	229	8	widespread	widespread	JJ
cord-016187-58rqc0cg	229	9	dissemination	dissemination	NN
cord-016187-58rqc0cg	229	10	of	of	IN
cord-016187-58rqc0cg	229	11	multiple	multiple	JJ
cord-016187-58rqc0cg	229	12	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	229	13	resistance	resistance	NN
cord-016187-58rqc0cg	229	14	genes	gene	NNS
cord-016187-58rqc0cg	229	15	is	be	VBZ
cord-016187-58rqc0cg	229	16	accomplished	accomplish	VBN
cord-016187-58rqc0cg	229	17	in	in	IN
cord-016187-58rqc0cg	229	18	a	a	DT
cord-016187-58rqc0cg	229	19	rapid	rapid	JJ
cord-016187-58rqc0cg	229	20	and	and	CC
cord-016187-58rqc0cg	229	21	frighteningly	frighteningly	RB
cord-016187-58rqc0cg	229	22	effi	effi	JJ
cord-016187-58rqc0cg	229	23	cient	cient	NN
cord-016187-58rqc0cg	229	24	manner	manner	NN
cord-016187-58rqc0cg	229	25	[	[	-LRB-
cord-016187-58rqc0cg	229	26	50	50	CD
cord-016187-58rqc0cg	229	27	]	]	-RRB-
cord-016187-58rqc0cg	229	28	.	.	.
cord-016187-58rqc0cg	230	1	For	for	IN
cord-016187-58rqc0cg	230	2	some	some	DT
cord-016187-58rqc0cg	230	3	time	time	NN
cord-016187-58rqc0cg	230	4	concerned	concern	VBN
cord-016187-58rqc0cg	230	5	scientists	scientist	NNS
cord-016187-58rqc0cg	230	6	have	have	VBP
cord-016187-58rqc0cg	230	7	been	be	VBN
cord-016187-58rqc0cg	230	8	warning	warn	VBG
cord-016187-58rqc0cg	230	9	about	about	IN
cord-016187-58rqc0cg	230	10	the	the	DT
cord-016187-58rqc0cg	230	11	possibility	possibility	NN
cord-016187-58rqc0cg	230	12	of	of	IN
cord-016187-58rqc0cg	230	13	widespread	widespread	JJ
cord-016187-58rqc0cg	230	14	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	230	15	resistance	resistance	NN
cord-016187-58rqc0cg	230	16	leading	lead	VBG
cord-016187-58rqc0cg	230	17	to	to	IN
cord-016187-58rqc0cg	230	18	the	the	DT
cord-016187-58rqc0cg	230	19	loss	loss	NN
cord-016187-58rqc0cg	230	20	of	of	IN
cord-016187-58rqc0cg	230	21	effectiveness	effectiveness	NN
cord-016187-58rqc0cg	230	22	of	of	IN
cord-016187-58rqc0cg	230	23	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	230	24	in	in	IN
cord-016187-58rqc0cg	230	25	clinical	clinical	JJ
cord-016187-58rqc0cg	230	26	medicine	medicine	NN
cord-016187-58rqc0cg	230	27	[	[	-LRB-
cord-016187-58rqc0cg	230	28	49	49	CD
cord-016187-58rqc0cg	230	29	]	]	-RRB-
cord-016187-58rqc0cg	230	30	[	[	-LRB-
cord-016187-58rqc0cg	230	31	50	50	CD
cord-016187-58rqc0cg	230	32	]	]	-RRB-
cord-016187-58rqc0cg	230	33	[	[	-LRB-
cord-016187-58rqc0cg	230	34	51	51	CD
cord-016187-58rqc0cg	230	35	]	]	-RRB-
cord-016187-58rqc0cg	230	36	[	[	-LRB-
cord-016187-58rqc0cg	230	37	52	52	CD
cord-016187-58rqc0cg	230	38	]	]	-RRB-
cord-016187-58rqc0cg	230	39	.	.	.
cord-016187-58rqc0cg	231	1	These	these	DT
cord-016187-58rqc0cg	231	2	warnings	warning	NNS
cord-016187-58rqc0cg	231	3	have	have	VBP
cord-016187-58rqc0cg	231	4	largely	largely	RB
cord-016187-58rqc0cg	231	5	been	be	VBN
cord-016187-58rqc0cg	231	6	ignored	ignore	VBN
cord-016187-58rqc0cg	231	7	as	as	IN
cord-016187-58rqc0cg	231	8	it	-PRON-	PRP
cord-016187-58rqc0cg	231	9	was	be	VBD
cord-016187-58rqc0cg	231	10	assumed	assume	VBN
cord-016187-58rqc0cg	231	11	that	that	IN
cord-016187-58rqc0cg	231	12	this	this	DT
cord-016187-58rqc0cg	231	13	human	human	JJ
cord-016187-58rqc0cg	231	14	need	need	NN
cord-016187-58rqc0cg	231	15	and	and	CC
cord-016187-58rqc0cg	231	16	the	the	DT
cord-016187-58rqc0cg	231	17	profi	profi	NNP
cord-016187-58rqc0cg	231	18	t	t	NNP
cord-016187-58rqc0cg	231	19	motive	motive	NN
cord-016187-58rqc0cg	231	20	of	of	IN
cord-016187-58rqc0cg	231	21	free	free	JJ
cord-016187-58rqc0cg	231	22	enterprise	enterprise	NN
cord-016187-58rqc0cg	231	23	would	would	MD
cord-016187-58rqc0cg	231	24	stimulate	stimulate	VB
cord-016187-58rqc0cg	231	25	pharmaceutical	pharmaceutical	JJ
cord-016187-58rqc0cg	231	26	companies	company	NNS
cord-016187-58rqc0cg	231	27	to	to	TO
cord-016187-58rqc0cg	231	28	continuously	continuously	RB
cord-016187-58rqc0cg	231	29	develop	develop	VB
cord-016187-58rqc0cg	231	30	new	new	JJ
cord-016187-58rqc0cg	231	31	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	231	32	.	.	.
cord-016187-58rqc0cg	232	1	If	if	IN
cord-016187-58rqc0cg	232	2	we	-PRON-	PRP
cord-016187-58rqc0cg	232	3	could	could	MD
cord-016187-58rqc0cg	232	4	discover	discover	VB
cord-016187-58rqc0cg	232	5	new	new	JJ
cord-016187-58rqc0cg	232	6	targets	target	NNS
cord-016187-58rqc0cg	232	7	for	for	IN
cord-016187-58rqc0cg	232	8	future	future	JJ
cord-016187-58rqc0cg	232	9	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	232	10	drugs	drug	NNS
cord-016187-58rqc0cg	232	11	it	-PRON-	PRP
cord-016187-58rqc0cg	232	12	may	may	MD
cord-016187-58rqc0cg	232	13	be	be	VB
cord-016187-58rqc0cg	232	14	possible	possible	JJ
cord-016187-58rqc0cg	232	15	to	to	TO
cord-016187-58rqc0cg	232	16	keep	keep	VB
cord-016187-58rqc0cg	232	17	pace	pace	NN
cord-016187-58rqc0cg	232	18	or	or	CC
cord-016187-58rqc0cg	232	19	even	even	RB
cord-016187-58rqc0cg	232	20	exceed	exceed	VB
cord-016187-58rqc0cg	232	21	the	the	DT
cord-016187-58rqc0cg	232	22	rate	rate	NN
cord-016187-58rqc0cg	232	23	of	of	IN
cord-016187-58rqc0cg	232	24	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	232	25	resistance	resistance	NN
cord-016187-58rqc0cg	232	26	gene	gene	NN
cord-016187-58rqc0cg	232	27	development	development	NN
cord-016187-58rqc0cg	232	28	by	by	IN
cord-016187-58rqc0cg	232	29	microbial	microbial	JJ
cord-016187-58rqc0cg	232	30	pathogens	pathogen	NNS
cord-016187-58rqc0cg	232	31	.	.	.
cord-016187-58rqc0cg	233	1	For	for	IN
cord-016187-58rqc0cg	233	2	a	a	DT
cord-016187-58rqc0cg	233	3	number	number	NN
cord-016187-58rqc0cg	233	4	of	of	IN
cord-016187-58rqc0cg	233	5	disconcerting	disconcerting	JJ
cord-016187-58rqc0cg	233	6	reasons	reason	NNS
cord-016187-58rqc0cg	233	7	,	,	,
cord-016187-58rqc0cg	233	8	humans	human	NNS
cord-016187-58rqc0cg	233	9	may	may	MD
cord-016187-58rqc0cg	233	10	be	be	VB
cord-016187-58rqc0cg	233	11	losing	lose	VBG
cord-016187-58rqc0cg	233	12	ground	ground	NN
cord-016187-58rqc0cg	233	13	rather	rather	RB
cord-016187-58rqc0cg	233	14	than	than	IN
cord-016187-58rqc0cg	233	15	gaining	gain	VBG
cord-016187-58rqc0cg	233	16	on	on	IN
cord-016187-58rqc0cg	233	17	pathogens	pathogen	NNS
cord-016187-58rqc0cg	233	18	in	in	IN
cord-016187-58rqc0cg	233	19	the	the	DT
cord-016187-58rqc0cg	233	20	21	21	CD
cord-016187-58rqc0cg	233	21	st	st	NNP
cord-016187-58rqc0cg	233	22	century	century	NN
cord-016187-58rqc0cg	233	23	.	.	.
cord-016187-58rqc0cg	234	1	A	a	DT
cord-016187-58rqc0cg	234	2	recent	recent	JJ
cord-016187-58rqc0cg	234	3	survey	survey	NN
cord-016187-58rqc0cg	234	4	of	of	IN
cord-016187-58rqc0cg	234	5	new	new	JJ
cord-016187-58rqc0cg	234	6	pharmaceutical	pharmaceutical	JJ
cord-016187-58rqc0cg	234	7	products	product	NNS
cord-016187-58rqc0cg	234	8	in	in	IN
cord-016187-58rqc0cg	234	9	2002	2002	CD
cord-016187-58rqc0cg	234	10	found	find	VBD
cord-016187-58rqc0cg	234	11	only	only	RB
cord-016187-58rqc0cg	234	12	fi	fi	NNP
cord-016187-58rqc0cg	234	13	ve	ve	VBD
cord-016187-58rqc0cg	234	14	new	new	JJ
cord-016187-58rqc0cg	234	15	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	234	16	out	out	IN
cord-016187-58rqc0cg	234	17	of	of	IN
cord-016187-58rqc0cg	234	18	the	the	DT
cord-016187-58rqc0cg	234	19	506	506	CD
cord-016187-58rqc0cg	234	20	new	new	JJ
cord-016187-58rqc0cg	234	21	molecular	molecular	JJ
cord-016187-58rqc0cg	234	22	entities	entity	NNS
cord-016187-58rqc0cg	234	23	in	in	IN
cord-016187-58rqc0cg	234	24	the	the	DT
cord-016187-58rqc0cg	234	25	research	research	NN
cord-016187-58rqc0cg	234	26	and	and	CC
cord-016187-58rqc0cg	234	27	development	development	NN
cord-016187-58rqc0cg	234	28	pipeline	pipeline	NN
cord-016187-58rqc0cg	234	29	[	[	-LRB-
cord-016187-58rqc0cg	234	30	52	52	CD
cord-016187-58rqc0cg	234	31	]	]	-RRB-
cord-016187-58rqc0cg	234	32	.	.	.
cord-016187-58rqc0cg	235	1	The	the	DT
cord-016187-58rqc0cg	235	2	pace	pace	NN
cord-016187-58rqc0cg	235	3	of	of	IN
cord-016187-58rqc0cg	235	4	new	new	JJ
cord-016187-58rqc0cg	235	5	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	235	6	discovery	discovery	NN
cord-016187-58rqc0cg	235	7	is	be	VBZ
cord-016187-58rqc0cg	235	8	turning	turn	VBG
cord-016187-58rqc0cg	235	9	into	into	IN
cord-016187-58rqc0cg	235	10	a	a	DT
cord-016187-58rqc0cg	235	11	trickle	trickle	NN
cord-016187-58rqc0cg	235	12	and	and	CC
cord-016187-58rqc0cg	235	13	drying	dry	VBG
cord-016187-58rqc0cg	235	14	up	up	RP
cord-016187-58rqc0cg	235	15	compared	compare	VBN
cord-016187-58rqc0cg	235	16	to	to	IN
cord-016187-58rqc0cg	235	17	what	what	WP
cord-016187-58rqc0cg	235	18	it	-PRON-	PRP
cord-016187-58rqc0cg	235	19	was	be	VBD
cord-016187-58rqc0cg	235	20	even	even	RB
cord-016187-58rqc0cg	235	21	20	20	CD
cord-016187-58rqc0cg	235	22	years	year	NNS
cord-016187-58rqc0cg	235	23	ago	ago	RB
cord-016187-58rqc0cg	235	24	[	[	-LRB-
cord-016187-58rqc0cg	235	25	53	53	CD
cord-016187-58rqc0cg	235	26	]	]	-RRB-
cord-016187-58rqc0cg	235	27	.	.	.
cord-016187-58rqc0cg	236	1	The	the	DT
cord-016187-58rqc0cg	236	2	market	market	NN
cord-016187-58rqc0cg	236	3	reality	reality	NN
cord-016187-58rqc0cg	236	4	is	be	VBZ
cord-016187-58rqc0cg	236	5	regrettably	regrettably	RB
cord-016187-58rqc0cg	236	6	set	set	VBN
cord-016187-58rqc0cg	236	7	against	against	IN
cord-016187-58rqc0cg	236	8	the	the	DT
cord-016187-58rqc0cg	236	9	development	development	NN
cord-016187-58rqc0cg	236	10	of	of	IN
cord-016187-58rqc0cg	236	11	new	new	JJ
cord-016187-58rqc0cg	236	12	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	236	13	in	in	IN
cord-016187-58rqc0cg	236	14	favor	favor	NN
cord-016187-58rqc0cg	236	15	of	of	IN
cord-016187-58rqc0cg	236	16	more	more	JJR
cord-016187-58rqc0cg	236	17	lucrative	lucrative	JJ
cord-016187-58rqc0cg	236	18	options	option	NNS
cord-016187-58rqc0cg	236	19	with	with	IN
cord-016187-58rqc0cg	236	20	greater	great	JJR
cord-016187-58rqc0cg	236	21	market	market	NN
cord-016187-58rqc0cg	236	22	profi	profi	NNP
cord-016187-58rqc0cg	236	23	t	t	NNP
cord-016187-58rqc0cg	236	24	from	from	IN
cord-016187-58rqc0cg	236	25	drugs	drug	NNS
cord-016187-58rqc0cg	236	26	for	for	IN
cord-016187-58rqc0cg	236	27	chronic	chronic	JJ
cord-016187-58rqc0cg	236	28	illnesses	illness	NNS
cord-016187-58rqc0cg	236	29	with	with	IN
cord-016187-58rqc0cg	236	30	less	less	JJR
cord-016187-58rqc0cg	236	31	risk	risk	NN
cord-016187-58rqc0cg	236	32	and	and	CC
cord-016187-58rqc0cg	236	33	longer	long	JJR
cord-016187-58rqc0cg	236	34	revenue	revenue	NN
cord-016187-58rqc0cg	236	35	streams	stream	NNS
cord-016187-58rqc0cg	236	36	[	[	-LRB-
cord-016187-58rqc0cg	236	37	52	52	CD
cord-016187-58rqc0cg	236	38	]	]	-RRB-
cord-016187-58rqc0cg	237	1	[	[	-LRB-
cord-016187-58rqc0cg	237	2	53	53	CD
cord-016187-58rqc0cg	237	3	]	]	-RRB-
cord-016187-58rqc0cg	237	4	[	[	-LRB-
cord-016187-58rqc0cg	237	5	54	54	CD
cord-016187-58rqc0cg	237	6	]	]	-RRB-
cord-016187-58rqc0cg	237	7	.	.	.
cord-016187-58rqc0cg	238	1	The	the	DT
cord-016187-58rqc0cg	238	2	reimbursement	reimbursement	NN
cord-016187-58rqc0cg	238	3	and	and	CC
cord-016187-58rqc0cg	238	4	return	return	NN
cord-016187-58rqc0cg	238	5	on	on	IN
cord-016187-58rqc0cg	238	6	investments	investment	NNS
cord-016187-58rqc0cg	238	7	are	be	VBP
cord-016187-58rqc0cg	238	8	unfavorable	unfavorable	JJ
cord-016187-58rqc0cg	238	9	for	for	IN
cord-016187-58rqc0cg	238	10	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	238	11	and	and	CC
cord-016187-58rqc0cg	238	12	the	the	DT
cord-016187-58rqc0cg	238	13	market	market	NN
cord-016187-58rqc0cg	238	14	system	system	NN
cord-016187-58rqc0cg	238	15	is	be	VBZ
cord-016187-58rqc0cg	238	16	not	not	RB
cord-016187-58rqc0cg	238	17	meeting	meet	VBG
cord-016187-58rqc0cg	238	18	the	the	DT
cord-016187-58rqc0cg	238	19	needs	need	NNS
cord-016187-58rqc0cg	238	20	of	of	IN
cord-016187-58rqc0cg	238	21	society	society	NN
cord-016187-58rqc0cg	238	22	with	with	IN
cord-016187-58rqc0cg	238	23	respect	respect	NN
cord-016187-58rqc0cg	238	24	to	to	IN
cord-016187-58rqc0cg	238	25	new	new	JJ
cord-016187-58rqc0cg	238	26	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	238	27	development	development	NN
cord-016187-58rqc0cg	238	28	.	.	.
cord-016187-58rqc0cg	239	1	Some	some	DT
cord-016187-58rqc0cg	239	2	far	far	RB
cord-016187-58rqc0cg	239	3	reaching	reach	VBG
cord-016187-58rqc0cg	239	4	and	and	CC
cord-016187-58rqc0cg	239	5	bold	bold	JJ
cord-016187-58rqc0cg	239	6	initiatives	initiative	NNS
cord-016187-58rqc0cg	239	7	are	be	VBP
cord-016187-58rqc0cg	239	8	desperately	desperately	RB
cord-016187-58rqc0cg	239	9	needed	need	VBN
cord-016187-58rqc0cg	239	10	if	if	IN
cord-016187-58rqc0cg	239	11	a	a	DT
cord-016187-58rqc0cg	239	12	crisis	crisis	NN
cord-016187-58rqc0cg	239	13	in	in	IN
cord-016187-58rqc0cg	239	14	loss	loss	NN
cord-016187-58rqc0cg	239	15	of	of	IN
cord-016187-58rqc0cg	239	16	antibi	antibi	NNP
cord-016187-58rqc0cg	239	17	-	-	HYPH
cord-016187-58rqc0cg	239	18	otic	otic	JJ
cord-016187-58rqc0cg	239	19	effectiveness	effectiveness	NN
cord-016187-58rqc0cg	239	20	is	be	VBZ
cord-016187-58rqc0cg	239	21	to	to	TO
cord-016187-58rqc0cg	239	22	be	be	VB
cord-016187-58rqc0cg	239	23	avoided	avoid	VBN
cord-016187-58rqc0cg	239	24	[	[	-LRB-
cord-016187-58rqc0cg	239	25	52	52	CD
cord-016187-58rqc0cg	239	26	,	,	,
cord-016187-58rqc0cg	239	27	53	53	CD
cord-016187-58rqc0cg	239	28	]	]	-RRB-
cord-016187-58rqc0cg	239	29	.	.	.
cord-016187-58rqc0cg	240	1	The	the	DT
cord-016187-58rqc0cg	240	2	disincentives	disincentive	NNS
cord-016187-58rqc0cg	240	3	for	for	IN
cord-016187-58rqc0cg	240	4	new	new	JJ
cord-016187-58rqc0cg	240	5	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	240	6	development	development	NN
cord-016187-58rqc0cg	240	7	and	and	CC
cord-016187-58rqc0cg	240	8	some	some	DT
cord-016187-58rqc0cg	240	9	proposed	propose	VBN
cord-016187-58rqc0cg	240	10	solutions	solution	NNS
cord-016187-58rqc0cg	240	11	are	be	VBP
cord-016187-58rqc0cg	240	12	listed	list	VBN
cord-016187-58rqc0cg	240	13	in	in	IN
cord-016187-58rqc0cg	240	14	Table	Table	NNP
cord-016187-58rqc0cg	240	15	4	4	CD
cord-016187-58rqc0cg	240	16	.	.	.
cord-016187-58rqc0cg	241	1	Bacterial	bacterial	JJ
cord-016187-58rqc0cg	241	2	strains	strain	NNS
cord-016187-58rqc0cg	241	3	contain	contain	VBP
cord-016187-58rqc0cg	241	4	complex	complex	JJ
cord-016187-58rqc0cg	241	5	aggregations	aggregation	NNS
cord-016187-58rqc0cg	241	6	of	of	IN
cord-016187-58rqc0cg	241	7	genes	gene	NNS
cord-016187-58rqc0cg	241	8	that	that	WDT
cord-016187-58rqc0cg	241	9	may	may	MD
cord-016187-58rqc0cg	241	10	be	be	VB
cord-016187-58rqc0cg	241	11	linked	link	VBN
cord-016187-58rqc0cg	241	12	together	together	RB
cord-016187-58rqc0cg	241	13	to	to	TO
cord-016187-58rqc0cg	241	14	combat	combat	VB
cord-016187-58rqc0cg	241	15	the	the	DT
cord-016187-58rqc0cg	241	16	inhibitory	inhibitory	JJ
cord-016187-58rqc0cg	241	17	effects	effect	NNS
cord-016187-58rqc0cg	241	18	of	of	IN
cord-016187-58rqc0cg	241	19	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	241	20	.	.	.
cord-016187-58rqc0cg	242	1	Since	since	IN
cord-016187-58rqc0cg	242	2	prokaryotic	prokaryotic	JJ
cord-016187-58rqc0cg	242	3	organisms	organism	NNS
cord-016187-58rqc0cg	242	4	all	all	DT
cord-016187-58rqc0cg	242	5	contribute	contribute	VBP
cord-016187-58rqc0cg	242	6	to	to	IN
cord-016187-58rqc0cg	242	7	a	a	DT
cord-016187-58rqc0cg	242	8	common	common	JJ
cord-016187-58rqc0cg	242	9	'	'	``
cord-016187-58rqc0cg	242	10	gene	gene	NN
cord-016187-58rqc0cg	242	11	pool	pool	NN
cord-016187-58rqc0cg	242	12	'	'	''
cord-016187-58rqc0cg	242	13	,	,	,
cord-016187-58rqc0cg	242	14	favorable	favorable	JJ
cord-016187-58rqc0cg	242	15	genes	gene	NNS
cord-016187-58rqc0cg	242	16	mediating	mediate	VBG
cord-016187-58rqc0cg	242	17	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	242	18	resistance	resistance	NN
cord-016187-58rqc0cg	242	19	may	may	MD
cord-016187-58rqc0cg	242	20	disseminate	disseminate	VB
cord-016187-58rqc0cg	242	21	among	among	IN
cord-016187-58rqc0cg	242	22	bacterial	bacterial	JJ
cord-016187-58rqc0cg	242	23	diverse	diverse	JJ
cord-016187-58rqc0cg	242	24	microbial	microbial	JJ
cord-016187-58rqc0cg	242	25	genera	genus	NNS
cord-016187-58rqc0cg	242	26	and	and	CC
cord-016187-58rqc0cg	242	27	species	specie	NNS
cord-016187-58rqc0cg	242	28	.	.	.
cord-016187-58rqc0cg	243	1	Increasing	increase	VBG
cord-016187-58rqc0cg	243	2	evidence	evidence	NN
cord-016187-58rqc0cg	243	3	of	of	IN
cord-016187-58rqc0cg	243	4	multiple	multiple	JJ
cord-016187-58rqc0cg	243	5	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	243	6	resistance	resistance	NN
cord-016187-58rqc0cg	243	7	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	243	8	within	within	IN
cord-016187-58rqc0cg	243	9	the	the	DT
cord-016187-58rqc0cg	243	10	same	same	JJ
cord-016187-58rqc0cg	243	11	bacterium	bacterium	NN
cord-016187-58rqc0cg	243	12	against	against	IN
cord-016187-58rqc0cg	243	13	a	a	DT
cord-016187-58rqc0cg	243	14	single	single	JJ
cord-016187-58rqc0cg	243	15	type	type	NN
cord-016187-58rqc0cg	243	16	of	of	IN
cord-016187-58rqc0cg	243	17	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	243	18	,	,	,
cord-016187-58rqc0cg	243	19	and	and	CC
cord-016187-58rqc0cg	243	20	cooperation	cooperation	NN
cord-016187-58rqc0cg	243	21	between	between	IN
cord-016187-58rqc0cg	243	22	bacterial	bacterial	JJ
cord-016187-58rqc0cg	243	23	populations	population	NNS
cord-016187-58rqc0cg	243	24	within	within	IN
cord-016187-58rqc0cg	243	25	biofi	biofi	NNP
cord-016187-58rqc0cg	243	26	lms	lms	NNP
cord-016187-58rqc0cg	243	27	attest	attest	VBP
cord-016187-58rqc0cg	243	28	to	to	IN
cord-016187-58rqc0cg	243	29	the	the	DT
cord-016187-58rqc0cg	243	30	remarkably	remarkably	JJ
cord-016187-58rqc0cg	243	31	ingenuity	ingenuity	NN
cord-016187-58rqc0cg	243	32	and	and	CC
cord-016187-58rqc0cg	243	33	fl	fl	JJ
cord-016187-58rqc0cg	243	34	exibility	exibility	NN
cord-016187-58rqc0cg	243	35	of	of	IN
cord-016187-58rqc0cg	243	36	bacterial	bacterial	JJ
cord-016187-58rqc0cg	243	37	populations	population	NNS
cord-016187-58rqc0cg	243	38	[	[	-LRB-
cord-016187-58rqc0cg	243	39	23	23	CD
cord-016187-58rqc0cg	243	40	,	,	,
cord-016187-58rqc0cg	243	41	29	29	CD
cord-016187-58rqc0cg	243	42	,	,	,
cord-016187-58rqc0cg	243	43	30	30	CD
cord-016187-58rqc0cg	243	44	]	]	-RRB-
cord-016187-58rqc0cg	243	45	.	.	.
cord-016187-58rqc0cg	244	1	Thus	thus	RB
cord-016187-58rqc0cg	244	2	the	the	DT
cord-016187-58rqc0cg	244	3	use	use	NN
cord-016187-58rqc0cg	244	4	of	of	IN
cord-016187-58rqc0cg	244	5	one	one	CD
cord-016187-58rqc0cg	244	6	antibiotic	antibiotic	NN
cord-016187-58rqc0cg	244	7	may	may	MD
cord-016187-58rqc0cg	244	8	select	select	VB
cord-016187-58rqc0cg	244	9	for	for	IN
cord-016187-58rqc0cg	244	10	the	the	DT
cord-016187-58rqc0cg	244	11	emergence	emergence	NN
cord-016187-58rqc0cg	244	12	of	of	IN
cord-016187-58rqc0cg	244	13	resistance	resistance	NN
cord-016187-58rqc0cg	244	14	to	to	IN
cord-016187-58rqc0cg	244	15	another	another	DT
cord-016187-58rqc0cg	244	16	.	.	.
cord-016187-58rqc0cg	245	1	Mobile	mobile	JJ
cord-016187-58rqc0cg	245	2	genetic	genetic	JJ
cord-016187-58rqc0cg	245	3	elements	element	NNS
cord-016187-58rqc0cg	245	4	and	and	CC
cord-016187-58rqc0cg	245	5	rapidly	rapidly	RB
cord-016187-58rqc0cg	245	6	evolving	evolve	VBG
cord-016187-58rqc0cg	245	7	integron	integron	NNP
cord-016187-58rqc0cg	245	8	cassettes	cassette	NNS
cord-016187-58rqc0cg	245	9	with	with	IN
cord-016187-58rqc0cg	245	10	multiple	multiple	JJ
cord-016187-58rqc0cg	245	11	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	245	12	resistance	resistance	NN
cord-016187-58rqc0cg	245	13	genes	gene	NNS
cord-016187-58rqc0cg	245	14	endow	endow	VBP
cord-016187-58rqc0cg	245	15	bacteria	bacteria	NNS
cord-016187-58rqc0cg	245	16	with	with	IN
cord-016187-58rqc0cg	245	17	a	a	DT
cord-016187-58rqc0cg	245	18	remarkable	remarkable	JJ
cord-016187-58rqc0cg	245	19	capacity	capacity	NN
cord-016187-58rqc0cg	245	20	to	to	TO
cord-016187-58rqc0cg	245	21	resist	resist	VB
cord-016187-58rqc0cg	245	22	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	245	23	[	[	-LRB-
cord-016187-58rqc0cg	245	24	50	50	CD
cord-016187-58rqc0cg	245	25	]	]	-RRB-
cord-016187-58rqc0cg	245	26	.	.	.
cord-016187-58rqc0cg	246	1	Although	although	IN
cord-016187-58rqc0cg	246	2	the	the	DT
cord-016187-58rqc0cg	246	3	development	development	NN
cord-016187-58rqc0cg	246	4	of	of	IN
cord-016187-58rqc0cg	246	5	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	246	6	resistance	resistance	NN
cord-016187-58rqc0cg	246	7	may	may	MD
cord-016187-58rqc0cg	246	8	be	be	VB
cord-016187-58rqc0cg	246	9	inevitable	inevitable	JJ
cord-016187-58rqc0cg	246	10	,	,	,
cord-016187-58rqc0cg	246	11	the	the	DT
cord-016187-58rqc0cg	246	12	rate	rate	NN
cord-016187-58rqc0cg	246	13	at	at	IN
cord-016187-58rqc0cg	246	14	which	which	WDT
cord-016187-58rqc0cg	246	15	it	-PRON-	PRP
cord-016187-58rqc0cg	246	16	develops	develop	VBZ
cord-016187-58rqc0cg	246	17	can	can	MD
cord-016187-58rqc0cg	246	18	be	be	VB
cord-016187-58rqc0cg	246	19	reduced	reduce	VBN
cord-016187-58rqc0cg	246	20	by	by	IN
cord-016187-58rqc0cg	246	21	the	the	DT
cord-016187-58rqc0cg	246	22	rational	rational	JJ
cord-016187-58rqc0cg	246	23	use	use	NN
cord-016187-58rqc0cg	246	24	of	of	IN
cord-016187-58rqc0cg	246	25	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	246	26	.	.	.
cord-016187-58rqc0cg	247	1	Use	use	NN
cord-016187-58rqc0cg	247	2	of	of	IN
cord-016187-58rqc0cg	247	3	19th	19th	JJ
cord-016187-58rqc0cg	247	4	century	century	NN
cord-016187-58rqc0cg	247	5	diagnostic	diagnostic	JJ
cord-016187-58rqc0cg	247	6	methods	method	NNS
cord-016187-58rqc0cg	247	7	Employ	employ	VBP
cord-016187-58rqc0cg	247	8	real	real	JJ
cord-016187-58rqc0cg	247	9	-	-	HYPH
cord-016187-58rqc0cg	247	10	time	time	NN
cord-016187-58rqc0cg	247	11	PCR	PCR	NNP
cord-016187-58rqc0cg	247	12	,	,	,
cord-016187-58rqc0cg	247	13	genomics	genomic	NNS
cord-016187-58rqc0cg	247	14	,	,	,
cord-016187-58rqc0cg	247	15	(	(	-LRB-
cord-016187-58rqc0cg	247	16	culture	culture	NN
cord-016187-58rqc0cg	247	17	and	and	CC
cord-016187-58rqc0cg	247	18	susceptibility	susceptibility	NN
cord-016187-58rqc0cg	247	19	tests	test	NNS
cord-016187-58rqc0cg	247	20	)	)	-RRB-
cord-016187-58rqc0cg	247	21	to	to	TO
cord-016187-58rqc0cg	247	22	treat	treat	VB
cord-016187-58rqc0cg	247	23	proteomics	proteomic	NNS
cord-016187-58rqc0cg	247	24	to	to	TO
cord-016187-58rqc0cg	247	25	identify	identify	VB
cord-016187-58rqc0cg	247	26	pathogens	pathogen	NNS
cord-016187-58rqc0cg	247	27	,	,	,
cord-016187-58rqc0cg	247	28	and	and	CC
cord-016187-58rqc0cg	247	29	21	21	CD
cord-016187-58rqc0cg	247	30	st	st	NNP
cord-016187-58rqc0cg	247	31	century	century	NN
cord-016187-58rqc0cg	247	32	diseases	disease	NNS
cord-016187-58rqc0cg	247	33	encourages	encourage	VBZ
cord-016187-58rqc0cg	247	34	empiric	empiric	JJ
cord-016187-58rqc0cg	247	35	resistance	resistance	NN
cord-016187-58rqc0cg	247	36	genes	gene	NNS
cord-016187-58rqc0cg	247	37	;	;	:
cord-016187-58rqc0cg	247	38	target	target	VB
cord-016187-58rqc0cg	247	39	and	and	CC
cord-016187-58rqc0cg	247	40	treat	treat	VB
cord-016187-58rqc0cg	247	41	specifi	specifi	NNP
cord-016187-58rqc0cg	247	42	c	c	NNP
cord-016187-58rqc0cg	247	43	broad	broad	JJ
cord-016187-58rqc0cg	247	44	-	-	HYPH
cord-016187-58rqc0cg	247	45	spectrum	spectrum	NN
cord-016187-58rqc0cg	247	46	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	247	47	drug	drug	NN
cord-016187-58rqc0cg	247	48	use	use	VBP
cord-016187-58rqc0cg	247	49	infections	infection	NNS
cord-016187-58rqc0cg	247	50	with	with	IN
cord-016187-58rqc0cg	247	51	narrow	narrow	JJ
cord-016187-58rqc0cg	247	52	spectrum	spectrum	NN
cord-016187-58rqc0cg	247	53	drugs	drug	NNS
cord-016187-58rqc0cg	247	54	PCR	PCR	NNP
cord-016187-58rqc0cg	247	55	:	:	:
cord-016187-58rqc0cg	247	56	polymerase	polymerase	NN
cord-016187-58rqc0cg	247	57	chain	chain	NN
cord-016187-58rqc0cg	247	58	reaction	reaction	NN
cord-016187-58rqc0cg	248	1	The	the	DT
cord-016187-58rqc0cg	248	2	wider	wide	JJR
cord-016187-58rqc0cg	248	3	accessibility	accessibility	NN
cord-016187-58rqc0cg	248	4	to	to	IN
cord-016187-58rqc0cg	248	5	molecular	molecular	JJ
cord-016187-58rqc0cg	248	6	techniques	technique	NNS
cord-016187-58rqc0cg	248	7	and	and	CC
cord-016187-58rqc0cg	248	8	computer	computer	NN
cord-016187-58rqc0cg	248	9	technology	technology	NN
cord-016187-58rqc0cg	248	10	to	to	TO
cord-016187-58rqc0cg	248	11	rapidly	rapidly	RB
cord-016187-58rqc0cg	248	12	identify	identify	VB
cord-016187-58rqc0cg	248	13	the	the	DT
cord-016187-58rqc0cg	248	14	specifi	specifi	NN
cord-016187-58rqc0cg	248	15	c	c	NN
cord-016187-58rqc0cg	248	16	microorganisms	microorganism	NNS
cord-016187-58rqc0cg	248	17	,	,	,
cord-016187-58rqc0cg	248	18	their	-PRON-	PRP$
cord-016187-58rqc0cg	248	19	resistance	resistance	NN
cord-016187-58rqc0cg	248	20	potential	potential	NN
cord-016187-58rqc0cg	248	21	,	,	,
cord-016187-58rqc0cg	248	22	and	and	CC
cord-016187-58rqc0cg	248	23	track	track	VB
cord-016187-58rqc0cg	248	24	their	-PRON-	PRP$
cord-016187-58rqc0cg	248	25	spread	spread	NN
cord-016187-58rqc0cg	248	26	between	between	IN
cord-016187-58rqc0cg	248	27	patients	patient	NNS
cord-016187-58rqc0cg	248	28	within	within	IN
cord-016187-58rqc0cg	248	29	the	the	DT
cord-016187-58rqc0cg	248	30	hospital	hospital	NN
cord-016187-58rqc0cg	248	31	and	and	CC
cord-016187-58rqc0cg	248	32	or	or	CC
cord-016187-58rqc0cg	248	33	the	the	DT
cord-016187-58rqc0cg	248	34	community	community	NN
cord-016187-58rqc0cg	248	35	will	will	MD
cord-016187-58rqc0cg	248	36	be	be	VB
cord-016187-58rqc0cg	248	37	of	of	IN
cord-016187-58rqc0cg	248	38	considerable	considerable	JJ
cord-016187-58rqc0cg	248	39	benefi	benefi	NNP
cord-016187-58rqc0cg	248	40	t	t	NN
cord-016187-58rqc0cg	248	41	in	in	IN
cord-016187-58rqc0cg	248	42	the	the	DT
cord-016187-58rqc0cg	248	43	control	control	NN
cord-016187-58rqc0cg	248	44	of	of	IN
cord-016187-58rqc0cg	248	45	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	248	46	resistance	resistance	NN
cord-016187-58rqc0cg	248	47	.	.	.
cord-016187-58rqc0cg	249	1	The	the	DT
cord-016187-58rqc0cg	249	2	need	need	NN
cord-016187-58rqc0cg	249	3	to	to	TO
cord-016187-58rqc0cg	249	4	utilize	utilize	VB
cord-016187-58rqc0cg	249	5	empiric	empiric	JJ
cord-016187-58rqc0cg	249	6	,	,	,
cord-016187-58rqc0cg	249	7	broad	broad	JJ
cord-016187-58rqc0cg	249	8	-	-	HYPH
cord-016187-58rqc0cg	249	9	spectrum	spectrum	NN
cord-016187-58rqc0cg	249	10	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	249	11	for	for	IN
cord-016187-58rqc0cg	249	12	days	day	NNS
cord-016187-58rqc0cg	249	13	and	and	CC
cord-016187-58rqc0cg	249	14	even	even	RB
cord-016187-58rqc0cg	249	15	weeks	week	NNS
cord-016187-58rqc0cg	249	16	while	while	IN
cord-016187-58rqc0cg	249	17	samples	sample	NNS
cord-016187-58rqc0cg	249	18	are	be	VBP
cord-016187-58rqc0cg	249	19	being	be	VBG
cord-016187-58rqc0cg	249	20	sent	send	VBN
cord-016187-58rqc0cg	249	21	for	for	IN
cord-016187-58rqc0cg	249	22	culture	culture	NN
cord-016187-58rqc0cg	249	23	and	and	CC
cord-016187-58rqc0cg	249	24	susceptibility	susceptibility	NN
cord-016187-58rqc0cg	249	25	testing	testing	NN
cord-016187-58rqc0cg	249	26	needs	need	VBZ
cord-016187-58rqc0cg	249	27	to	to	TO
cord-016187-58rqc0cg	249	28	stop	stop	VB
cord-016187-58rqc0cg	249	29	.	.	.
cord-016187-58rqc0cg	250	1	We	-PRON-	PRP
cord-016187-58rqc0cg	250	2	need	need	VBP
cord-016187-58rqc0cg	250	3	specifi	specifi	NN
cord-016187-58rqc0cg	250	4	c	c	NN
cord-016187-58rqc0cg	250	5	information	information	NN
cord-016187-58rqc0cg	250	6	in	in	IN
cord-016187-58rqc0cg	250	7	real	real	JJ
cord-016187-58rqc0cg	250	8	time	time	NN
cord-016187-58rqc0cg	250	9	to	to	TO
cord-016187-58rqc0cg	250	10	assure	assure	VB
cord-016187-58rqc0cg	250	11	patients	patient	NNS
cord-016187-58rqc0cg	250	12	with	with	IN
cord-016187-58rqc0cg	250	13	specifi	specifi	NNP
cord-016187-58rqc0cg	250	14	c	c	NN
cord-016187-58rqc0cg	250	15	infections	infection	NNS
cord-016187-58rqc0cg	250	16	are	be	VBP
cord-016187-58rqc0cg	250	17	being	be	VBG
cord-016187-58rqc0cg	250	18	treated	treat	VBN
cord-016187-58rqc0cg	250	19	with	with	IN
cord-016187-58rqc0cg	250	20	effective	effective	JJ
cord-016187-58rqc0cg	250	21	,	,	,
cord-016187-58rqc0cg	250	22	narrow	narrow	JJ
cord-016187-58rqc0cg	250	23	-	-	HYPH
cord-016187-58rqc0cg	250	24	spectrum	spectrum	NN
cord-016187-58rqc0cg	250	25	drugs	drug	NNS
cord-016187-58rqc0cg	250	26	[	[	-LRB-
cord-016187-58rqc0cg	250	27	23	23	CD
cord-016187-58rqc0cg	250	28	]	]	-RRB-
cord-016187-58rqc0cg	250	29	.	.	.
cord-016187-58rqc0cg	251	1	The	the	DT
cord-016187-58rqc0cg	251	2	use	use	NN
cord-016187-58rqc0cg	251	3	of	of	IN
cord-016187-58rqc0cg	251	4	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	251	5	for	for	IN
cord-016187-58rqc0cg	251	6	non	non	JJ
cord-016187-58rqc0cg	251	7	-	-	JJ
cord-016187-58rqc0cg	251	8	medical	medical	JJ
cord-016187-58rqc0cg	251	9	uses	use	NNS
cord-016187-58rqc0cg	251	10	should	should	MD
cord-016187-58rqc0cg	251	11	be	be	VB
cord-016187-58rqc0cg	251	12	entirely	entirely	RB
cord-016187-58rqc0cg	251	13	banned	ban	VBN
cord-016187-58rqc0cg	251	14	.	.	.
cord-016187-58rqc0cg	252	1	Up	up	IN
cord-016187-58rqc0cg	252	2	to	to	TO
cord-016187-58rqc0cg	252	3	50	50	CD
cord-016187-58rqc0cg	252	4	%	%	NN
cord-016187-58rqc0cg	252	5	of	of	IN
cord-016187-58rqc0cg	252	6	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	252	7	use	use	NN
cord-016187-58rqc0cg	252	8	today	today	NN
cord-016187-58rqc0cg	252	9	is	be	VBZ
cord-016187-58rqc0cg	252	10	for	for	IN
cord-016187-58rqc0cg	252	11	non	non	JJ
cord-016187-58rqc0cg	252	12	-	-	JJ
cord-016187-58rqc0cg	252	13	medical	medical	JJ
cord-016187-58rqc0cg	252	14	use	use	NN
cord-016187-58rqc0cg	252	15	in	in	IN
cord-016187-58rqc0cg	252	16	agriculture	agriculture	NN
cord-016187-58rqc0cg	252	17	,	,	,
cord-016187-58rqc0cg	252	18	food	food	NN
cord-016187-58rqc0cg	252	19	preparation	preparation	NN
cord-016187-58rqc0cg	252	20	,	,	,
cord-016187-58rqc0cg	252	21	and	and	CC
cord-016187-58rqc0cg	252	22	other	other	JJ
cord-016187-58rqc0cg	252	23	industrial	industrial	JJ
cord-016187-58rqc0cg	252	24	uses	use	NNS
cord-016187-58rqc0cg	252	25	[	[	-LRB-
cord-016187-58rqc0cg	252	26	52	52	CD
cord-016187-58rqc0cg	252	27	]	]	-RRB-
cord-016187-58rqc0cg	252	28	.	.	.
cord-016187-58rqc0cg	253	1	This	this	DT
cord-016187-58rqc0cg	253	2	adds	add	VBZ
cord-016187-58rqc0cg	253	3	to	to	IN
cord-016187-58rqc0cg	253	4	environmental	environmental	JJ
cord-016187-58rqc0cg	253	5	contamination	contamination	NN
cord-016187-58rqc0cg	253	6	with	with	IN
cord-016187-58rqc0cg	253	7	low	low	JJ
cord-016187-58rqc0cg	253	8	levels	level	NNS
cord-016187-58rqc0cg	253	9	of	of	IN
cord-016187-58rqc0cg	253	10	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	253	11	.	.	.
cord-016187-58rqc0cg	254	1	Sub	sub	JJ
cord-016187-58rqc0cg	254	2	-	-	HYPH
cord-016187-58rqc0cg	254	3	inhibitory	inhibitory	JJ
cord-016187-58rqc0cg	254	4	concentrations	concentration	NNS
cord-016187-58rqc0cg	254	5	of	of	IN
cord-016187-58rqc0cg	254	6	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	254	7	foster	foster	VBP
cord-016187-58rqc0cg	254	8	the	the	DT
cord-016187-58rqc0cg	254	9	development	development	NN
cord-016187-58rqc0cg	254	10	of	of	IN
cord-016187-58rqc0cg	254	11	resistant	resistant	JJ
cord-016187-58rqc0cg	254	12	clones	clone	NNS
cord-016187-58rqc0cg	254	13	of	of	IN
cord-016187-58rqc0cg	254	14	bacteria	bacteria	NNS
cord-016187-58rqc0cg	254	15	that	that	WDT
cord-016187-58rqc0cg	254	16	can	can	MD
cord-016187-58rqc0cg	254	17	cause	cause	VB
cord-016187-58rqc0cg	254	18	infections	infection	NNS
cord-016187-58rqc0cg	254	19	in	in	IN
cord-016187-58rqc0cg	254	20	humans	human	NNS
cord-016187-58rqc0cg	254	21	.	.	.
cord-016187-58rqc0cg	255	1	The	the	DT
cord-016187-58rqc0cg	255	2	use	use	NN
cord-016187-58rqc0cg	255	3	of	of	IN
cord-016187-58rqc0cg	255	4	non	non	JJ
cord-016187-58rqc0cg	255	5	-	-	JJ
cord-016187-58rqc0cg	255	6	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	255	7	approaches	approach	NNS
cord-016187-58rqc0cg	255	8	to	to	IN
cord-016187-58rqc0cg	255	9	the	the	DT
cord-016187-58rqc0cg	255	10	management	management	NN
cord-016187-58rqc0cg	255	11	of	of	IN
cord-016187-58rqc0cg	255	12	infectious	infectious	JJ
cord-016187-58rqc0cg	255	13	diseases	disease	NNS
cord-016187-58rqc0cg	255	14	needs	need	VBZ
cord-016187-58rqc0cg	255	15	to	to	TO
cord-016187-58rqc0cg	255	16	be	be	VB
cord-016187-58rqc0cg	255	17	supported	support	VBN
cord-016187-58rqc0cg	255	18	and	and	CC
cord-016187-58rqc0cg	255	19	developed	develop	VBN
cord-016187-58rqc0cg	255	20	.	.	.
cord-016187-58rqc0cg	256	1	The	the	DT
cord-016187-58rqc0cg	256	2	use	use	NN
cord-016187-58rqc0cg	256	3	of	of	IN
cord-016187-58rqc0cg	256	4	plasma	plasma	NN
cord-016187-58rqc0cg	256	5	-	-	HYPH
cord-016187-58rqc0cg	256	6	based	base	VBN
cord-016187-58rqc0cg	256	7	antibody	antibody	NN
cord-016187-58rqc0cg	256	8	therapies	therapy	NNS
cord-016187-58rqc0cg	256	9	and	and	CC
cord-016187-58rqc0cg	256	10	anti	anti	JJ
cord-016187-58rqc0cg	256	11	-	-	JJ
cord-016187-58rqc0cg	256	12	bacterial	bacterial	JJ
cord-016187-58rqc0cg	256	13	,	,	,
cord-016187-58rqc0cg	256	14	anti	anti	JJ
cord-016187-58rqc0cg	256	15	-	-	JJ
cord-016187-58rqc0cg	256	16	viral	viral	JJ
cord-016187-58rqc0cg	256	17	and	and	CC
cord-016187-58rqc0cg	256	18	anti	anti	JJ
cord-016187-58rqc0cg	256	19	-	-	JJ
cord-016187-58rqc0cg	256	20	fungal	fungal	JJ
cord-016187-58rqc0cg	256	21	vaccines	vaccine	NNS
cord-016187-58rqc0cg	256	22	should	should	MD
cord-016187-58rqc0cg	256	23	be	be	VB
cord-016187-58rqc0cg	256	24	encouraged	encourage	VBN
cord-016187-58rqc0cg	256	25	in	in	IN
cord-016187-58rqc0cg	256	26	the	the	DT
cord-016187-58rqc0cg	256	27	future	future	NN
cord-016187-58rqc0cg	256	28	[	[	-LRB-
cord-016187-58rqc0cg	256	29	55	55	CD
cord-016187-58rqc0cg	256	30	]	]	-RRB-
cord-016187-58rqc0cg	256	31	[	[	-LRB-
cord-016187-58rqc0cg	256	32	56	56	CD
cord-016187-58rqc0cg	256	33	]	]	-RRB-
cord-016187-58rqc0cg	256	34	[	[	-LRB-
cord-016187-58rqc0cg	256	35	57	57	CD
cord-016187-58rqc0cg	256	36	]	]	-RRB-
cord-016187-58rqc0cg	256	37	.	.	.
cord-016187-58rqc0cg	257	1	The	the	DT
cord-016187-58rqc0cg	257	2	management	management	NN
cord-016187-58rqc0cg	257	3	of	of	IN
cord-016187-58rqc0cg	257	4	common	common	JJ
cord-016187-58rqc0cg	257	5	invasive	invasive	JJ
cord-016187-58rqc0cg	257	6	pathogens	pathogen	NNS
cord-016187-58rqc0cg	257	7	such	such	JJ
cord-016187-58rqc0cg	257	8	as	as	IN
cord-016187-58rqc0cg	257	9	staphylococcal	staphylococcal	JJ
cord-016187-58rqc0cg	257	10	infections	infection	NNS
cord-016187-58rqc0cg	257	11	has	have	VBZ
cord-016187-58rqc0cg	257	12	become	become	VBN
cord-016187-58rqc0cg	257	13	very	very	RB
cord-016187-58rqc0cg	257	14	complicated	complicated	JJ
cord-016187-58rqc0cg	257	15	given	give	VBN
cord-016187-58rqc0cg	257	16	the	the	DT
cord-016187-58rqc0cg	257	17	rapid	rapid	JJ
cord-016187-58rqc0cg	257	18	spread	spread	NN
cord-016187-58rqc0cg	257	19	of	of	IN
cord-016187-58rqc0cg	257	20	simultaneous	simultaneous	JJ
cord-016187-58rqc0cg	257	21	beta	beta	NN
cord-016187-58rqc0cg	257	22	-	-	HYPH
cord-016187-58rqc0cg	257	23	lactam	lactam	NN
cord-016187-58rqc0cg	257	24	,	,	,
cord-016187-58rqc0cg	257	25	aminoglycoside	aminoglycoside	NNP
cord-016187-58rqc0cg	257	26	,	,	,
cord-016187-58rqc0cg	257	27	and	and	CC
cord-016187-58rqc0cg	257	28	quinolone	quinolone	NN
cord-016187-58rqc0cg	257	29	-	-	HYPH
cord-016187-58rqc0cg	257	30	resistant	resistant	JJ
cord-016187-58rqc0cg	257	31	isolates	isolate	NNS
cord-016187-58rqc0cg	257	32	[	[	-LRB-
cord-016187-58rqc0cg	257	33	58	58	CD
cord-016187-58rqc0cg	257	34	]	]	-RRB-
cord-016187-58rqc0cg	257	35	.	.	.
cord-016187-58rqc0cg	258	1	Recent	recent	JJ
cord-016187-58rqc0cg	258	2	reports	report	NNS
cord-016187-58rqc0cg	258	3	of	of	IN
cord-016187-58rqc0cg	258	4	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	258	5	-	-	HYPH
cord-016187-58rqc0cg	258	6	resistant	resistant	JJ
cord-016187-58rqc0cg	258	7	S.	S.	NNP
cord-016187-58rqc0cg	258	8	aureus	aureus	NN
cord-016187-58rqc0cg	258	9	in	in	IN
cord-016187-58rqc0cg	258	10	Japan	Japan	NNP
cord-016187-58rqc0cg	258	11	and	and	CC
cord-016187-58rqc0cg	258	12	the	the	DT
cord-016187-58rqc0cg	258	13	United	United	NNP
cord-016187-58rqc0cg	258	14	States	States	NNP
cord-016187-58rqc0cg	258	15	suggest	suggest	VBP
cord-016187-58rqc0cg	258	16	that	that	IN
cord-016187-58rqc0cg	258	17	common	common	JJ
cord-016187-58rqc0cg	258	18	,	,	,
cord-016187-58rqc0cg	258	19	invasive	invasive	JJ
cord-016187-58rqc0cg	258	20	,	,	,
cord-016187-58rqc0cg	258	21	microbial	microbial	JJ
cord-016187-58rqc0cg	258	22	pathogens	pathogen	NNS
cord-016187-58rqc0cg	258	23	may	may	MD
cord-016187-58rqc0cg	258	24	become	become	VB
cord-016187-58rqc0cg	258	25	refractory	refractory	JJ
cord-016187-58rqc0cg	258	26	to	to	IN
cord-016187-58rqc0cg	258	27	any	any	DT
cord-016187-58rqc0cg	258	28	chemotherapeutic	chemotherapeutic	JJ
cord-016187-58rqc0cg	258	29	agent	agent	NN
cord-016187-58rqc0cg	258	30	in	in	IN
cord-016187-58rqc0cg	258	31	the	the	DT
cord-016187-58rqc0cg	258	32	future	future	NN
cord-016187-58rqc0cg	258	33	[	[	-LRB-
cord-016187-58rqc0cg	258	34	17	17	CD
cord-016187-58rqc0cg	258	35	,	,	,
cord-016187-58rqc0cg	258	36	23	23	CD
cord-016187-58rqc0cg	258	37	,	,	,
cord-016187-58rqc0cg	258	38	58	58	CD
cord-016187-58rqc0cg	258	39	]	]	-RRB-
cord-016187-58rqc0cg	258	40	.	.	.
cord-016187-58rqc0cg	259	1	New	new	JJ
cord-016187-58rqc0cg	259	2	drug	drug	NN
cord-016187-58rqc0cg	259	3	discoveries	discovery	NNS
cord-016187-58rqc0cg	259	4	have	have	VBP
cord-016187-58rqc0cg	259	5	allowed	allow	VBN
cord-016187-58rqc0cg	259	6	us	-PRON-	PRP
cord-016187-58rqc0cg	259	7	to	to	TO
cord-016187-58rqc0cg	259	8	be	be	VB
cord-016187-58rqc0cg	259	9	one	one	CD
cord-016187-58rqc0cg	259	10	step	step	NN
cord-016187-58rqc0cg	259	11	ahead	ahead	RB
cord-016187-58rqc0cg	259	12	of	of	IN
cord-016187-58rqc0cg	259	13	the	the	DT
cord-016187-58rqc0cg	259	14	bacterial	bacterial	JJ
cord-016187-58rqc0cg	259	15	pathogens	pathogen	NNS
cord-016187-58rqc0cg	259	16	for	for	IN
cord-016187-58rqc0cg	259	17	the	the	DT
cord-016187-58rqc0cg	259	18	latter	latter	JJ
cord-016187-58rqc0cg	259	19	half	half	NN
cord-016187-58rqc0cg	259	20	of	of	IN
cord-016187-58rqc0cg	259	21	the	the	DT
cord-016187-58rqc0cg	259	22	twentieth	twentieth	JJ
cord-016187-58rqc0cg	259	23	century	century	NN
cord-016187-58rqc0cg	259	24	.	.	.
cord-016187-58rqc0cg	260	1	It	-PRON-	PRP
cord-016187-58rqc0cg	260	2	is	be	VBZ
cord-016187-58rqc0cg	260	3	unlikely	unlikely	JJ
cord-016187-58rqc0cg	260	4	we	-PRON-	PRP
cord-016187-58rqc0cg	260	5	will	will	MD
cord-016187-58rqc0cg	260	6	continue	continue	VB
cord-016187-58rqc0cg	260	7	this	this	DT
cord-016187-58rqc0cg	260	8	record	record	NN
cord-016187-58rqc0cg	260	9	of	of	IN
cord-016187-58rqc0cg	260	10	remarkable	remarkable	JJ
cord-016187-58rqc0cg	260	11	success	success	NN
cord-016187-58rqc0cg	260	12	against	against	IN
cord-016187-58rqc0cg	260	13	microbial	microbial	JJ
cord-016187-58rqc0cg	260	14	pathogens	pathogen	NNS
cord-016187-58rqc0cg	260	15	in	in	IN
cord-016187-58rqc0cg	260	16	the	the	DT
cord-016187-58rqc0cg	260	17	new	new	JJ
cord-016187-58rqc0cg	260	18	millennium	millennium	NN
cord-016187-58rqc0cg	260	19	.	.	.
cord-016187-58rqc0cg	261	1	The	the	DT
cord-016187-58rqc0cg	261	2	rapid	rapid	JJ
cord-016187-58rqc0cg	261	3	evolution	evolution	NN
cord-016187-58rqc0cg	261	4	of	of	IN
cord-016187-58rqc0cg	261	5	resistance	resistance	NN
cord-016187-58rqc0cg	261	6	has	have	VBZ
cord-016187-58rqc0cg	261	7	limited	limit	VBN
cord-016187-58rqc0cg	261	8	the	the	DT
cord-016187-58rqc0cg	261	9	duration	duration	NN
cord-016187-58rqc0cg	261	10	of	of	IN
cord-016187-58rqc0cg	261	11	the	the	DT
cord-016187-58rqc0cg	261	12	effectiveness	effectiveness	NN
cord-016187-58rqc0cg	261	13	of	of	IN
cord-016187-58rqc0cg	261	14	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	261	15	against	against	IN
cord-016187-58rqc0cg	261	16	certain	certain	JJ
cord-016187-58rqc0cg	261	17	pathogens	pathogen	NNS
cord-016187-58rqc0cg	261	18	.	.	.
cord-016187-58rqc0cg	262	1	The	the	DT
cord-016187-58rqc0cg	262	2	best	good	JJS
cord-016187-58rqc0cg	262	3	hope	hope	NN
cord-016187-58rqc0cg	262	4	for	for	IN
cord-016187-58rqc0cg	262	5	the	the	DT
cord-016187-58rqc0cg	262	6	future	future	NN
cord-016187-58rqc0cg	262	7	is	be	VBZ
cord-016187-58rqc0cg	262	8	the	the	DT
cord-016187-58rqc0cg	262	9	continued	continue	VBN
cord-016187-58rqc0cg	262	10	development	development	NN
cord-016187-58rqc0cg	262	11	of	of	IN
cord-016187-58rqc0cg	262	12	new	new	JJ
cord-016187-58rqc0cg	262	13	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	262	14	strategies	strategy	NNS
cord-016187-58rqc0cg	262	15	[	[	-LRB-
cord-016187-58rqc0cg	262	16	53	53	CD
cord-016187-58rqc0cg	262	17	]	]	-RRB-
cord-016187-58rqc0cg	262	18	.	.	.
cord-016187-58rqc0cg	263	1	In	in	IN
cord-016187-58rqc0cg	263	2	order	order	NN
cord-016187-58rqc0cg	263	3	to	to	TO
cord-016187-58rqc0cg	263	4	retain	retain	VB
cord-016187-58rqc0cg	263	5	the	the	DT
cord-016187-58rqc0cg	263	6	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	263	7	activity	activity	NN
cord-016187-58rqc0cg	263	8	of	of	IN
cord-016187-58rqc0cg	263	9	existing	exist	VBG
cord-016187-58rqc0cg	263	10	and	and	CC
cord-016187-58rqc0cg	263	11	new	new	JJ
cord-016187-58rqc0cg	263	12	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	263	13	,	,	,
cord-016187-58rqc0cg	263	14	clinicians	clinician	NNS
cord-016187-58rqc0cg	263	15	can	can	MD
cord-016187-58rqc0cg	263	16	assist	assist	VB
cord-016187-58rqc0cg	263	17	through	through	IN
cord-016187-58rqc0cg	263	18	careful	careful	JJ
cord-016187-58rqc0cg	263	19	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	263	20	stewardship	stewardship	NN
cord-016187-58rqc0cg	263	21	and	and	CC
cord-016187-58rqc0cg	263	22	tightened	tighten	VBD
cord-016187-58rqc0cg	263	23	infection	infection	NN
cord-016187-58rqc0cg	263	24	control	control	NN
cord-016187-58rqc0cg	263	25	measures	measure	NNS
cord-016187-58rqc0cg	263	26	.	.	.
cord-016187-58rqc0cg	264	1	Antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	264	2	agents	agent	NNS
cord-016187-58rqc0cg	264	3	have	have	VBP
cord-016187-58rqc0cg	264	4	had	have	VBN
cord-016187-58rqc0cg	264	5	a	a	DT
cord-016187-58rqc0cg	264	6	substantial	substantial	JJ
cord-016187-58rqc0cg	264	7	impact	impact	NN
cord-016187-58rqc0cg	264	8	in	in	IN
cord-016187-58rqc0cg	264	9	decreasing	decrease	VBG
cord-016187-58rqc0cg	264	10	human	human	JJ
cord-016187-58rqc0cg	264	11	morbidity	morbidity	NN
cord-016187-58rqc0cg	264	12	and	and	CC
cord-016187-58rqc0cg	264	13	mortality	mortality	NN
cord-016187-58rqc0cg	264	14	rates	rate	NNS
cord-016187-58rqc0cg	264	15	and	and	CC
cord-016187-58rqc0cg	264	16	have	have	VBP
cord-016187-58rqc0cg	264	17	served	serve	VBN
cord-016187-58rqc0cg	264	18	us	-PRON-	PRP
cord-016187-58rqc0cg	264	19	well	well	RB
cord-016187-58rqc0cg	264	20	over	over	IN
cord-016187-58rqc0cg	264	21	the	the	DT
cord-016187-58rqc0cg	264	22	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	264	23	era	era	NN
cord-016187-58rqc0cg	264	24	.	.	.
cord-016187-58rqc0cg	265	1	It	-PRON-	PRP
cord-016187-58rqc0cg	265	2	behooves	behooves	VBP
cord-016187-58rqc0cg	265	3	us	-PRON-	PRP
cord-016187-58rqc0cg	265	4	to	to	TO
cord-016187-58rqc0cg	265	5	improve	improve	VB
cord-016187-58rqc0cg	265	6	our	-PRON-	PRP$
cord-016187-58rqc0cg	265	7	diagnostic	diagnostic	JJ
cord-016187-58rqc0cg	265	8	and	and	CC
cord-016187-58rqc0cg	265	9	surveillance	surveillance	NN
cord-016187-58rqc0cg	265	10	efforts	effort	NNS
cord-016187-58rqc0cg	265	11	and	and	CC
cord-016187-58rqc0cg	265	12	to	to	TO
cord-016187-58rqc0cg	265	13	exercise	exercise	VB
cord-016187-58rqc0cg	265	14	caution	caution	NN
cord-016187-58rqc0cg	265	15	in	in	IN
cord-016187-58rqc0cg	265	16	administering	administer	VBG
cord-016187-58rqc0cg	265	17	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	265	18	if	if	IN
cord-016187-58rqc0cg	265	19	we	-PRON-	PRP
cord-016187-58rqc0cg	265	20	are	be	VBP
cord-016187-58rqc0cg	265	21	to	to	TO
cord-016187-58rqc0cg	265	22	maintain	maintain	VB
cord-016187-58rqc0cg	265	23	their	-PRON-	PRP$
cord-016187-58rqc0cg	265	24	continued	continue	VBN
cord-016187-58rqc0cg	265	25	effi	effi	NNP
cord-016187-58rqc0cg	265	26	cacy	cacy	NN
cord-016187-58rqc0cg	265	27	.	.	.
cord-016187-58rqc0cg	266	1	Forecast	forecast	NN
cord-016187-58rqc0cg	266	2	and	and	CC
cord-016187-58rqc0cg	266	3	control	control	NN
cord-016187-58rqc0cg	266	4	of	of	IN
cord-016187-58rqc0cg	266	5	epidemics	epidemic	NNS
cord-016187-58rqc0cg	266	6	in	in	IN
cord-016187-58rqc0cg	266	7	a	a	DT
cord-016187-58rqc0cg	266	8	globalized	globalized	JJ
cord-016187-58rqc0cg	266	9	world	world	NN
cord-016187-58rqc0cg	266	10	Multidrug	Multidrug	NNP
cord-016187-58rqc0cg	266	11	resistance	resistance	NN
cord-016187-58rqc0cg	266	12	in	in	IN
cord-016187-58rqc0cg	266	13	Yersinia	Yersinia	NNP
cord-016187-58rqc0cg	266	14	pestis	pestis	NN
cord-016187-58rqc0cg	266	15	mediated	mediate	VBN
cord-016187-58rqc0cg	266	16	by	by	IN
cord-016187-58rqc0cg	266	17	a	a	DT
cord-016187-58rqc0cg	266	18	transferable	transferable	JJ
cord-016187-58rqc0cg	266	19	plasmid	plasmid	NN
cord-016187-58rqc0cg	266	20	H5N1	H5N1	NNP
cord-016187-58rqc0cg	266	21	infl	infl	NNP
cord-016187-58rqc0cg	266	22	uenza	uenza	NNP
cord-016187-58rqc0cg	266	23	:	:	:
cord-016187-58rqc0cg	266	24	a	a	DT
cord-016187-58rqc0cg	266	25	protean	protean	JJ
cord-016187-58rqc0cg	266	26	pandemic	pandemic	NN
cord-016187-58rqc0cg	266	27	threat	threat	NN
cord-016187-58rqc0cg	266	28	Induction	Induction	NNP
cord-016187-58rqc0cg	266	29	of	of	IN
cord-016187-58rqc0cg	266	30	proinfl	proinfl	NNP
cord-016187-58rqc0cg	266	31	ammatory	ammatory	NNP
cord-016187-58rqc0cg	266	32	cytokines	cytokine	NNS
cord-016187-58rqc0cg	266	33	in	in	IN
cord-016187-58rqc0cg	266	34	human	human	JJ
cord-016187-58rqc0cg	266	35	macrophages	macrophage	NNS
cord-016187-58rqc0cg	266	36	by	by	IN
cord-016187-58rqc0cg	266	37	infl	infl	NNP
cord-016187-58rqc0cg	266	38	uenza	uenza	NNP
cord-016187-58rqc0cg	266	39	A	A	NNP
cord-016187-58rqc0cg	266	40	(	(	-LRB-
cord-016187-58rqc0cg	266	41	H5N1	H5N1	NNP
cord-016187-58rqc0cg	266	42	)	)	-RRB-
cord-016187-58rqc0cg	266	43	wiruses	wiruses	NNP
cord-016187-58rqc0cg	266	44	:	:	:
cord-016187-58rqc0cg	266	45	a	a	DT
cord-016187-58rqc0cg	266	46	mechanism	mechanism	NN
cord-016187-58rqc0cg	266	47	for	for	IN
cord-016187-58rqc0cg	266	48	the	the	DT
cord-016187-58rqc0cg	266	49	unusual	unusual	JJ
cord-016187-58rqc0cg	266	50	severity	severity	NN
cord-016187-58rqc0cg	266	51	of	of	IN
cord-016187-58rqc0cg	266	52	human	human	JJ
cord-016187-58rqc0cg	266	53	disease	disease	NN
cord-016187-58rqc0cg	266	54	Enhanced	enhance	VBN
cord-016187-58rqc0cg	266	55	virulence	virulence	NN
cord-016187-58rqc0cg	266	56	of	of	IN
cord-016187-58rqc0cg	266	57	infl	infl	NN
cord-016187-58rqc0cg	266	58	uenza	uenza	NNP
cord-016187-58rqc0cg	266	59	A	a	DT
cord-016187-58rqc0cg	266	60	viruses	virus	NNS
cord-016187-58rqc0cg	266	61	with	with	IN
cord-016187-58rqc0cg	266	62	the	the	DT
cord-016187-58rqc0cg	266	63	haemagglutinin	haemagglutinin	NNP
cord-016187-58rqc0cg	266	64	of	of	IN
cord-016187-58rqc0cg	266	65	the	the	DT
cord-016187-58rqc0cg	266	66	1918	1918	CD
cord-016187-58rqc0cg	266	67	pandemic	pandemic	NNP
cord-016187-58rqc0cg	266	68	virus	virus	NN
cord-016187-58rqc0cg	267	1	The	the	DT
cord-016187-58rqc0cg	267	2	structure	structure	NN
cord-016187-58rqc0cg	267	3	and	and	CC
cord-016187-58rqc0cg	267	4	receptor	receptor	NN
cord-016187-58rqc0cg	267	5	binding	bind	VBG
cord-016187-58rqc0cg	267	6	properties	property	NNS
cord-016187-58rqc0cg	267	7	of	of	IN
cord-016187-58rqc0cg	267	8	the	the	DT
cord-016187-58rqc0cg	267	9	1918	1918	CD
cord-016187-58rqc0cg	267	10	infl	infl	NNP
cord-016187-58rqc0cg	267	11	uenza	uenza	NNP
cord-016187-58rqc0cg	267	12	hemagglutinin	hemagglutinin	VBN
cord-016187-58rqc0cg	267	13	Viral	viral	JJ
cord-016187-58rqc0cg	267	14	shedding	shed	VBG
cord-016187-58rqc0cg	267	15	patterns	pattern	NNS
cord-016187-58rqc0cg	267	16	of	of	IN
cord-016187-58rqc0cg	267	17	coronavirus	coronavirus	NN
cord-016187-58rqc0cg	267	18	in	in	IN
cord-016187-58rqc0cg	267	19	patients	patient	NNS
cord-016187-58rqc0cg	267	20	with	with	IN
cord-016187-58rqc0cg	267	21	probable	probable	JJ
cord-016187-58rqc0cg	267	22	severe	severe	JJ
cord-016187-58rqc0cg	267	23	acute	acute	JJ
cord-016187-58rqc0cg	267	24	respiratory	respiratory	JJ
cord-016187-58rqc0cg	267	25	syndrome	syndrome	NN
cord-016187-58rqc0cg	267	26	Planning	plan	VBG
cord-016187-58rqc0cg	267	27	for	for	IN
cord-016187-58rqc0cg	267	28	epidemics	epidemic	NNS
cord-016187-58rqc0cg	268	1	-The	-The	:
cord-016187-58rqc0cg	268	2	lessons	lesson	NNS
cord-016187-58rqc0cg	268	3	of	of	IN
cord-016187-58rqc0cg	268	4	SARS	SARS	NNP
cord-016187-58rqc0cg	268	5	Public	Public	NNP
cord-016187-58rqc0cg	268	6	health	health	NN
cord-016187-58rqc0cg	268	7	measures	measure	NNS
cord-016187-58rqc0cg	268	8	to	to	TO
cord-016187-58rqc0cg	268	9	control	control	VB
cord-016187-58rqc0cg	268	10	the	the	DT
cord-016187-58rqc0cg	268	11	spread	spread	NN
cord-016187-58rqc0cg	268	12	of	of	IN
cord-016187-58rqc0cg	268	13	the	the	DT
cord-016187-58rqc0cg	268	14	severe	severe	JJ
cord-016187-58rqc0cg	268	15	acute	acute	JJ
cord-016187-58rqc0cg	268	16	respiratory	respiratory	JJ
cord-016187-58rqc0cg	268	17	syndrome	syndrome	NN
cord-016187-58rqc0cg	268	18	during	during	IN
cord-016187-58rqc0cg	268	19	the	the	DT
cord-016187-58rqc0cg	268	20	outbreak	outbreak	NN
cord-016187-58rqc0cg	268	21	in	in	IN
cord-016187-58rqc0cg	268	22	Toronto	Toronto	NNP
cord-016187-58rqc0cg	268	23	Multistate	multistate	JJ
cord-016187-58rqc0cg	268	24	outbreak	outbreak	NN
cord-016187-58rqc0cg	268	25	of	of	IN
cord-016187-58rqc0cg	268	26	monkeypox	monkeypox	NNP
cord-016187-58rqc0cg	268	27	-	-	:
cord-016187-58rqc0cg	268	28	Illinois	Illinois	NNP
cord-016187-58rqc0cg	268	29	Westward	Westward	NNP
cord-016187-58rqc0cg	268	30	HO	HO	NNP
cord-016187-58rqc0cg	268	31	?	?	.
cord-016187-58rqc0cg	269	1	-The	-The	NNP
cord-016187-58rqc0cg	269	2	spread	spread	NN
cord-016187-58rqc0cg	269	3	of	of	IN
cord-016187-58rqc0cg	269	4	West	West	NNP
cord-016187-58rqc0cg	269	5	Nile	Nile	NNP
cord-016187-58rqc0cg	269	6	virus	virus	NN
cord-016187-58rqc0cg	269	7	Death	death	NN
cord-016187-58rqc0cg	269	8	from	from	IN
cord-016187-58rqc0cg	269	9	the	the	DT
cord-016187-58rqc0cg	269	10	Nile	Nile	NNP
cord-016187-58rqc0cg	269	11	crosses	cross	VBZ
cord-016187-58rqc0cg	269	12	the	the	DT
cord-016187-58rqc0cg	269	13	Atlantic	Atlantic	NNP
cord-016187-58rqc0cg	269	14	:	:	:
cord-016187-58rqc0cg	269	15	The	the	DT
cord-016187-58rqc0cg	269	16	West	West	NNP
cord-016187-58rqc0cg	269	17	Nile	Nile	NNP
cord-016187-58rqc0cg	269	18	fever	fever	NN
cord-016187-58rqc0cg	269	19	story	story	NN
cord-016187-58rqc0cg	269	20	Hemorrhagic	hemorrhagic	JJ
cord-016187-58rqc0cg	269	21	fever	fever	NN
cord-016187-58rqc0cg	269	22	viruses	virus	NNS
cord-016187-58rqc0cg	269	23	as	as	IN
cord-016187-58rqc0cg	269	24	biological	biological	JJ
cord-016187-58rqc0cg	269	25	weapons	weapon	NNS
cord-016187-58rqc0cg	269	26	Death	death	NN
cord-016187-58rqc0cg	269	27	due	due	IN
cord-016187-58rqc0cg	269	28	to	to	IN
cord-016187-58rqc0cg	269	29	bioterrorism	bioterrorism	NN
cord-016187-58rqc0cg	269	30	-	-	HYPH
cord-016187-58rqc0cg	269	31	related	relate	VBN
cord-016187-58rqc0cg	269	32	anthrax	anthrax	NN
cord-016187-58rqc0cg	269	33	:	:	:
cord-016187-58rqc0cg	269	34	Report	report	NN
cord-016187-58rqc0cg	269	35	of	of	IN
cord-016187-58rqc0cg	269	36	two	two	CD
cord-016187-58rqc0cg	269	37	patients	patient	NNS
cord-016187-58rqc0cg	269	38	Isolation	isolation	NN
cord-016187-58rqc0cg	269	39	and	and	CC
cord-016187-58rqc0cg	269	40	partial	partial	JJ
cord-016187-58rqc0cg	269	41	molecular	molecular	JJ
cord-016187-58rqc0cg	269	42	characterization	characterization	NN
cord-016187-58rqc0cg	269	43	of	of	IN
cord-016187-58rqc0cg	269	44	a	a	DT
cord-016187-58rqc0cg	269	45	strain	strain	NN
cord-016187-58rqc0cg	269	46	of	of	IN
cord-016187-58rqc0cg	269	47	Ebola	Ebola	NNP
cord-016187-58rqc0cg	269	48	virus	virus	NN
cord-016187-58rqc0cg	269	49	during	during	IN
cord-016187-58rqc0cg	269	50	a	a	DT
cord-016187-58rqc0cg	269	51	recent	recent	JJ
cord-016187-58rqc0cg	269	52	epidemic	epidemic	NN
cord-016187-58rqc0cg	269	53	of	of	IN
cord-016187-58rqc0cg	269	54	viral	viral	JJ
cord-016187-58rqc0cg	269	55	haemorrhagic	haemorrhagic	JJ
cord-016187-58rqc0cg	269	56	fever	fever	NN
cord-016187-58rqc0cg	269	57	in	in	IN
cord-016187-58rqc0cg	269	58	Gabon	Gabon	NNP
cord-016187-58rqc0cg	269	59	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	269	60	aureus	aureus	NN
cord-016187-58rqc0cg	269	61	resistant	resistant	JJ
cord-016187-58rqc0cg	269	62	to	to	IN
cord-016187-58rqc0cg	269	63	Vancomycin	Vancomycin	NNP
cord-016187-58rqc0cg	269	64	-	-	HYPH
cord-016187-58rqc0cg	269	65	United	United	NNP
cord-016187-58rqc0cg	269	66	States	States	NNP
cord-016187-58rqc0cg	269	67	Oseltamivir	Oseltamivir	NNP
cord-016187-58rqc0cg	269	68	-	-	HYPH
cord-016187-58rqc0cg	269	69	resistant	resistant	JJ
cord-016187-58rqc0cg	269	70	infl	infl	NN
cord-016187-58rqc0cg	269	71	uenza	uenza	NN
cord-016187-58rqc0cg	269	72	?	?	.
cord-016187-58rqc0cg	270	1	Resistant	resistant	JJ
cord-016187-58rqc0cg	270	2	infl	infl	XX
cord-016187-58rqc0cg	270	3	uenza	uenza	NN
cord-016187-58rqc0cg	271	1	A	a	DT
cord-016187-58rqc0cg	271	2	viruses	virus	NNS
cord-016187-58rqc0cg	271	3	in	in	IN
cord-016187-58rqc0cg	271	4	children	child	NNS
cord-016187-58rqc0cg	271	5	treated	treat	VBN
cord-016187-58rqc0cg	271	6	with	with	IN
cord-016187-58rqc0cg	271	7	oseltamivir	oseltamivir	NNP
cord-016187-58rqc0cg	271	8	:	:	:
cord-016187-58rqc0cg	271	9	descriptive	descriptive	JJ
cord-016187-58rqc0cg	271	10	study	study	NN
cord-016187-58rqc0cg	271	11	Resistance	resistance	NN
cord-016187-58rqc0cg	271	12	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	271	13	in	in	IN
cord-016187-58rqc0cg	271	14	clinical	clinical	JJ
cord-016187-58rqc0cg	271	15	isolates	isolate	NNS
cord-016187-58rqc0cg	271	16	of	of	IN
cord-016187-58rqc0cg	271	17	Candida	Candida	NNP
cord-016187-58rqc0cg	271	18	albicans	albican	NNS
cord-016187-58rqc0cg	271	19	Creutzfeldt	Creutzfeldt	NNP
cord-016187-58rqc0cg	271	20	-	-	HYPH
cord-016187-58rqc0cg	271	21	Jakob	Jakob	NNP
cord-016187-58rqc0cg	271	22	Disease	Disease	NNP
cord-016187-58rqc0cg	271	23	and	and	CC
cord-016187-58rqc0cg	271	24	related	relate	VBN
cord-016187-58rqc0cg	271	25	transmissible	transmissible	JJ
cord-016187-58rqc0cg	271	26	spongiform	spongiform	JJ
cord-016187-58rqc0cg	271	27	encephalopathies	encephalopathy	NNS
cord-016187-58rqc0cg	271	28	Outbreaks	outbreak	NNS
cord-016187-58rqc0cg	271	29	of	of	IN
cord-016187-58rqc0cg	271	30	avian	avian	JJ
cord-016187-58rqc0cg	271	31	infl	infl	NN
cord-016187-58rqc0cg	271	32	uenza	uenza	NNP
cord-016187-58rqc0cg	271	33	A	A	NNP
cord-016187-58rqc0cg	271	34	(	(	-LRB-
cord-016187-58rqc0cg	271	35	H5N1	H5N1	NNP
cord-016187-58rqc0cg	271	36	)	)	-RRB-
cord-016187-58rqc0cg	271	37	in	in	IN
cord-016187-58rqc0cg	271	38	Asia	Asia	NNP
cord-016187-58rqc0cg	271	39	and	and	CC
cord-016187-58rqc0cg	271	40	interim	interim	JJ
cord-016187-58rqc0cg	271	41	recommendations	recommendation	NNS
cord-016187-58rqc0cg	271	42	for	for	IN
cord-016187-58rqc0cg	271	43	evaluation	evaluation	NN
cord-016187-58rqc0cg	271	44	and	and	CC
cord-016187-58rqc0cg	271	45	reporting	reporting	NN
cord-016187-58rqc0cg	271	46	of	of	IN
cord-016187-58rqc0cg	271	47	suspected	suspect	VBN
cord-016187-58rqc0cg	271	48	cases	case	NNS
cord-016187-58rqc0cg	272	1	-United	-unite	VBN
cord-016187-58rqc0cg	273	1	States	States	NNP
cord-016187-58rqc0cg	273	2	Mechanisms	Mechanisms	NNPS
cord-016187-58rqc0cg	273	3	of	of	IN
cord-016187-58rqc0cg	273	4	Antibiotic	Antibiotic	NNP
cord-016187-58rqc0cg	273	5	Resistance	Resistance	NNP
cord-016187-58rqc0cg	274	1	A	a	DT
cord-016187-58rqc0cg	274	2	functional	functional	JJ
cord-016187-58rqc0cg	274	3	classifi	classifi	NN
cord-016187-58rqc0cg	274	4	cation	cation	NN
cord-016187-58rqc0cg	274	5	scheme	scheme	NN
cord-016187-58rqc0cg	274	6	for	for	IN
cord-016187-58rqc0cg	274	7	βlactamases	βlactamase	NNS
cord-016187-58rqc0cg	274	8	and	and	CC
cord-016187-58rqc0cg	274	9	its	-PRON-	PRP$
cord-016187-58rqc0cg	274	10	correlation	correlation	NN
cord-016187-58rqc0cg	274	11	with	with	IN
cord-016187-58rqc0cg	274	12	molecular	molecular	JJ
cord-016187-58rqc0cg	274	13	structure	structure	NN
cord-016187-58rqc0cg	274	14	Error	error	NN
cord-016187-58rqc0cg	274	15	-	-	HYPH
cord-016187-58rqc0cg	274	16	prone	prone	JJ
cord-016187-58rqc0cg	274	17	polymerase	polymerase	NN
cord-016187-58rqc0cg	274	18	,	,	,
cord-016187-58rqc0cg	274	19	DNA	dna	NN
cord-016187-58rqc0cg	274	20	polymerase	polymerase	NN
cord-016187-58rqc0cg	274	21	IV	IV	NNP
cord-016187-58rqc0cg	274	22	,	,	,
cord-016187-58rqc0cg	274	23	is	be	VBZ
cord-016187-58rqc0cg	274	24	responsible	responsible	JJ
cord-016187-58rqc0cg	274	25	for	for	IN
cord-016187-58rqc0cg	274	26	transient	transient	JJ
cord-016187-58rqc0cg	274	27	hypermutation	hypermutation	NN
cord-016187-58rqc0cg	274	28	during	during	IN
cord-016187-58rqc0cg	274	29	adaptive	adaptive	JJ
cord-016187-58rqc0cg	274	30	mutation	mutation	NN
cord-016187-58rqc0cg	274	31	in	in	IN
cord-016187-58rqc0cg	274	32	Escherichia	Escherichia	NNP
cord-016187-58rqc0cg	274	33	coli	coli	VBZ
cord-016187-58rqc0cg	274	34	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	274	35	biofi	biofi	NNP
cord-016187-58rqc0cg	274	36	lm	lm	NNP
cord-016187-58rqc0cg	274	37	formation	formation	NN
cord-016187-58rqc0cg	274	38	and	and	CC
cord-016187-58rqc0cg	274	39	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	274	40	resistance	resistance	NN
cord-016187-58rqc0cg	274	41	are	be	VBP
cord-016187-58rqc0cg	274	42	linked	link	VBN
cord-016187-58rqc0cg	274	43	to	to	IN
cord-016187-58rqc0cg	274	44	phenotypic	phenotypic	JJ
cord-016187-58rqc0cg	274	45	variation	variation	NN
cord-016187-58rqc0cg	274	46	Infection	infection	NN
cord-016187-58rqc0cg	274	47	with	with	IN
cord-016187-58rqc0cg	274	48	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	274	49	-	-	HYPH
cord-016187-58rqc0cg	274	50	resistant	resistant	JJ
cord-016187-58rqc0cg	274	51	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	274	52	aureus	aureus	NN
cord-016187-58rqc0cg	274	53	containing	contain	VBG
cord-016187-58rqc0cg	274	54	the	the	DT
cord-016187-58rqc0cg	274	55	vanA	vanA	NNP
cord-016187-58rqc0cg	274	56	resistance	resistance	NN
cord-016187-58rqc0cg	274	57	gene	gene	NN
cord-016187-58rqc0cg	274	58	Multifocal	multifocal	JJ
cord-016187-58rqc0cg	274	59	outbreaks	outbreak	NNS
cord-016187-58rqc0cg	274	60	of	of	IN
cord-016187-58rqc0cg	274	61	metallo	metallo	NN
cord-016187-58rqc0cg	274	62	-	-	HYPH
cord-016187-58rqc0cg	274	63	βlactamase	βlactamase	NN
cord-016187-58rqc0cg	274	64	-	-	HYPH
cord-016187-58rqc0cg	274	65	producing	produce	VBG
cord-016187-58rqc0cg	274	66	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	274	67	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	274	68	resistant	resistant	JJ
cord-016187-58rqc0cg	274	69	to	to	IN
cord-016187-58rqc0cg	274	70	broad	broad	JJ
cord-016187-58rqc0cg	274	71	-	-	HYPH
cord-016187-58rqc0cg	274	72	spectrum	spectrum	NN
cord-016187-58rqc0cg	274	73	β	β	NN
cord-016187-58rqc0cg	274	74	-	-	HYPH
cord-016187-58rqc0cg	274	75	lactams	lactam	NNS
cord-016187-58rqc0cg	274	76	,	,	,
cord-016187-58rqc0cg	274	77	including	include	VBG
cord-016187-58rqc0cg	274	78	carbapenems	carbapenem	NNS
cord-016187-58rqc0cg	274	79	Antimicrobial	Antimicrobial	NNP
cord-016187-58rqc0cg	274	80	resistance	resistance	NN
cord-016187-58rqc0cg	274	81	in	in	IN
cord-016187-58rqc0cg	274	82	intensive	intensive	JJ
cord-016187-58rqc0cg	274	83	care	care	NN
cord-016187-58rqc0cg	274	84	units	unit	NNS
cord-016187-58rqc0cg	275	1	The	the	DT
cord-016187-58rqc0cg	275	2	origins	origin	NNS
cord-016187-58rqc0cg	275	3	and	and	CC
cord-016187-58rqc0cg	275	4	molecular	molecular	JJ
cord-016187-58rqc0cg	275	5	basis	basis	NN
cord-016187-58rqc0cg	275	6	of	of	IN
cord-016187-58rqc0cg	275	7	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	275	8	resistance	resistance	NN
cord-016187-58rqc0cg	275	9	Acquisition	Acquisition	NNP
cord-016187-58rqc0cg	275	10	of	of	IN
cord-016187-58rqc0cg	275	11	16S	16S	NNP
cord-016187-58rqc0cg	275	12	rRNA	rRNA	NNP
cord-016187-58rqc0cg	275	13	methylase	methylase	NNP
cord-016187-58rqc0cg	275	14	gene	gene	NN
cord-016187-58rqc0cg	275	15	in	in	IN
cord-016187-58rqc0cg	275	16	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	275	17	aeruginosa	aeruginosa	VBZ
cord-016187-58rqc0cg	275	18	Interactions	Interactions	NNPS
cord-016187-58rqc0cg	275	19	of	of	IN
cord-016187-58rqc0cg	275	20	outer	outer	JJ
cord-016187-58rqc0cg	275	21	membrane	membrane	NN
cord-016187-58rqc0cg	275	22	proteins	protein	NNS
cord-016187-58rqc0cg	275	23	0	0	CD
cord-016187-58rqc0cg	275	24	-	-	SYM
cord-016187-58rqc0cg	275	25	8	8	CD
cord-016187-58rqc0cg	275	26	and	and	CC
cord-016187-58rqc0cg	275	27	0	0	CD
cord-016187-58rqc0cg	275	28	-	-	SYM
cord-016187-58rqc0cg	275	29	9	9	CD
cord-016187-58rqc0cg	275	30	with	with	IN
cord-016187-58rqc0cg	275	31	peptidoglycan	peptidoglycan	JJ
cord-016187-58rqc0cg	275	32	sacculus	sacculus	NN
cord-016187-58rqc0cg	275	33	of	of	IN
cord-016187-58rqc0cg	275	34	Escherichia	Escherichia	NNP
cord-016187-58rqc0cg	275	35	coli	coli	VBZ
cord-016187-58rqc0cg	275	36	K-12	K-12	NNP
cord-016187-58rqc0cg	275	37	Interplay	Interplay	NNP
cord-016187-58rqc0cg	275	38	of	of	IN
cord-016187-58rqc0cg	275	39	impermeability	impermeability	NN
cord-016187-58rqc0cg	275	40	and	and	CC
cord-016187-58rqc0cg	275	41	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	275	42	beta	beta	NN
cord-016187-58rqc0cg	275	43	-	-	HYPH
cord-016187-58rqc0cg	275	44	lactamase	lactamase	NN
cord-016187-58rqc0cg	275	45	activity	activity	NN
cord-016187-58rqc0cg	275	46	in	in	IN
cord-016187-58rqc0cg	275	47	imipenem	imipenem	JJ
cord-016187-58rqc0cg	275	48	-	-	HYPH
cord-016187-58rqc0cg	275	49	resistant	resistant	JJ
cord-016187-58rqc0cg	275	50	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	275	51	aeruginosa	aeruginosa	NN
cord-016187-58rqc0cg	275	52	Membrane	Membrane	NNP
cord-016187-58rqc0cg	275	53	potential	potential	NN
cord-016187-58rqc0cg	275	54	and	and	CC
cord-016187-58rqc0cg	275	55	gentamicin	gentamicin	NN
cord-016187-58rqc0cg	275	56	uptake	uptake	NN
cord-016187-58rqc0cg	275	57	in	in	IN
cord-016187-58rqc0cg	275	58	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	275	59	aureus	aureus	NNP
cord-016187-58rqc0cg	275	60	Drug	Drug	NNP
cord-016187-58rqc0cg	275	61	effl	effl	NNP
cord-016187-58rqc0cg	275	62	ux	ux	NNP
cord-016187-58rqc0cg	275	63	as	as	IN
cord-016187-58rqc0cg	275	64	a	a	DT
cord-016187-58rqc0cg	275	65	mechanism	mechanism	NN
cord-016187-58rqc0cg	275	66	of	of	IN
cord-016187-58rqc0cg	275	67	resistance	resistance	NN
cord-016187-58rqc0cg	275	68	Active	active	JJ
cord-016187-58rqc0cg	275	69	effl	effl	NNP
cord-016187-58rqc0cg	275	70	ux	ux	NNP
cord-016187-58rqc0cg	275	71	,	,	,
cord-016187-58rqc0cg	275	72	a	a	DT
cord-016187-58rqc0cg	275	73	common	common	JJ
cord-016187-58rqc0cg	275	74	mechanism	mechanism	NN
cord-016187-58rqc0cg	275	75	for	for	IN
cord-016187-58rqc0cg	275	76	biocide	biocide	NN
cord-016187-58rqc0cg	275	77	and	and	CC
cord-016187-58rqc0cg	275	78	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	275	79	resistance	resistance	NN
cord-016187-58rqc0cg	275	80	Inner	inner	JJ
cord-016187-58rqc0cg	275	81	membrane	membrane	NN
cord-016187-58rqc0cg	275	82	effl	effl	NNP
cord-016187-58rqc0cg	275	83	ux	ux	NNP
cord-016187-58rqc0cg	275	84	components	component	NNS
cord-016187-58rqc0cg	276	1	are	be	VBP
cord-016187-58rqc0cg	276	2	responsible	responsible	JJ
cord-016187-58rqc0cg	276	3	for	for	IN
cord-016187-58rqc0cg	276	4	β	β	NN
cord-016187-58rqc0cg	276	5	-	-	HYPH
cord-016187-58rqc0cg	276	6	lactam	lactam	NNP
cord-016187-58rqc0cg	276	7	specifi	specifi	NN
cord-016187-58rqc0cg	276	8	city	city	NN
cord-016187-58rqc0cg	276	9	of	of	IN
cord-016187-58rqc0cg	276	10	multidrug	multidrug	NN
cord-016187-58rqc0cg	276	11	effl	effl	NNP
cord-016187-58rqc0cg	276	12	ux	ux	NNP
cord-016187-58rqc0cg	276	13	pumps	pump	NNS
cord-016187-58rqc0cg	276	14	in	in	IN
cord-016187-58rqc0cg	276	15	Pseudomonas	Pseudomonas	NNP
cord-016187-58rqc0cg	276	16	aeruginosa	aeruginosa	VBZ
cord-016187-58rqc0cg	276	17	Genetic	genetic	JJ
cord-016187-58rqc0cg	276	18	characterization	characterization	NN
cord-016187-58rqc0cg	276	19	of	of	IN
cord-016187-58rqc0cg	276	20	vanG	vanG	NNS
cord-016187-58rqc0cg	276	21	,	,	,
cord-016187-58rqc0cg	276	22	a	a	DT
cord-016187-58rqc0cg	276	23	novel	novel	NN
cord-016187-58rqc0cg	276	24	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	276	25	resistance	resistance	NN
cord-016187-58rqc0cg	276	26	locus	locus	NN
cord-016187-58rqc0cg	276	27	for	for	IN
cord-016187-58rqc0cg	276	28	Enterococcus	Enterococcus	NNP
cord-016187-58rqc0cg	276	29	faecalis	faecalis	NNP
cord-016187-58rqc0cg	277	1	Contribution	contribution	NN
cord-016187-58rqc0cg	277	2	of	of	IN
cord-016187-58rqc0cg	277	3	a	a	DT
cord-016187-58rqc0cg	277	4	thickened	thickened	JJ
cord-016187-58rqc0cg	277	5	cell	cell	NN
cord-016187-58rqc0cg	277	6	wall	wall	NN
cord-016187-58rqc0cg	277	7	and	and	CC
cord-016187-58rqc0cg	277	8	its	-PRON-	PRP$
cord-016187-58rqc0cg	277	9	glutamine	glutamine	NN
cord-016187-58rqc0cg	277	10	nonamidated	nonamidate	VBN
cord-016187-58rqc0cg	277	11	component	component	NN
cord-016187-58rqc0cg	277	12	to	to	IN
cord-016187-58rqc0cg	277	13	the	the	DT
cord-016187-58rqc0cg	277	14	vancomycin	vancomycin	NN
cord-016187-58rqc0cg	277	15	resistance	resistance	NN
cord-016187-58rqc0cg	277	16	expressed	express	VBN
cord-016187-58rqc0cg	277	17	by	by	IN
cord-016187-58rqc0cg	277	18	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	277	19	aureus	aureus	NN
cord-016187-58rqc0cg	277	20	M450	M450	NNP
cord-016187-58rqc0cg	277	21	Transition	transition	NN
cord-016187-58rqc0cg	277	22	from	from	IN
cord-016187-58rqc0cg	277	23	resistance	resistance	NN
cord-016187-58rqc0cg	277	24	to	to	IN
cord-016187-58rqc0cg	277	25	hypersusceptibility	hypersusceptibility	NN
cord-016187-58rqc0cg	277	26	to	to	IN
cord-016187-58rqc0cg	277	27	beta	beta	NN
cord-016187-58rqc0cg	277	28	-	-	HYPH
cord-016187-58rqc0cg	277	29	lactam	lactam	NN
cord-016187-58rqc0cg	277	30	antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	277	31	associated	associate	VBN
cord-016187-58rqc0cg	277	32	with	with	IN
cord-016187-58rqc0cg	277	33	loss	loss	NN
cord-016187-58rqc0cg	277	34	of	of	IN
cord-016187-58rqc0cg	277	35	a	a	DT
cord-016187-58rqc0cg	277	36	low	low	RB
cord-016187-58rqc0cg	277	37	-	-	HYPH
cord-016187-58rqc0cg	277	38	affi	affi	JJ
cord-016187-58rqc0cg	277	39	nity	nity	NNP
cord-016187-58rqc0cg	277	40	penicillin	penicillin	NN
cord-016187-58rqc0cg	277	41	-	-	HYPH
cord-016187-58rqc0cg	277	42	binding	bind	VBG
cord-016187-58rqc0cg	277	43	protein	protein	NN
cord-016187-58rqc0cg	277	44	in	in	IN
cord-016187-58rqc0cg	277	45	a	a	DT
cord-016187-58rqc0cg	277	46	Streptococcus	Streptococcus	NNP
cord-016187-58rqc0cg	277	47	faecium	faecium	NN
cord-016187-58rqc0cg	277	48	mutant	mutant	NN
cord-016187-58rqc0cg	277	49	highly	highly	RB
cord-016187-58rqc0cg	277	50	resistant	resistant	JJ
cord-016187-58rqc0cg	277	51	to	to	IN
cord-016187-58rqc0cg	277	52	penicillin	penicillin	NN
cord-016187-58rqc0cg	277	53	Penicillin	Penicillin	NNP
cord-016187-58rqc0cg	277	54	-	-	HYPH
cord-016187-58rqc0cg	277	55	binding	bind	VBG
cord-016187-58rqc0cg	277	56	proteins	protein	NNS
cord-016187-58rqc0cg	277	57	and	and	CC
cord-016187-58rqc0cg	277	58	ampicillin	ampicillin	JJ
cord-016187-58rqc0cg	277	59	resistance	resistance	NN
cord-016187-58rqc0cg	277	60	in	in	IN
cord-016187-58rqc0cg	277	61	Haemophilus	haemophilus	JJ
cord-016187-58rqc0cg	277	62	infl	infl	NN
cord-016187-58rqc0cg	277	63	uenzae	uenzae	NN
cord-016187-58rqc0cg	277	64	Activity	activity	NN
cord-016187-58rqc0cg	277	65	of	of	IN
cord-016187-58rqc0cg	277	66	quinolones	quinolone	NNS
cord-016187-58rqc0cg	277	67	against	against	IN
cord-016187-58rqc0cg	277	68	gram	gram	NN
cord-016187-58rqc0cg	277	69	-	-	HYPH
cord-016187-58rqc0cg	277	70	positive	positive	JJ
cord-016187-58rqc0cg	277	71	cocci	coccus	NNS
cord-016187-58rqc0cg	277	72	:	:	:
cord-016187-58rqc0cg	277	73	mechanisms	mechanism	NNS
cord-016187-58rqc0cg	277	74	of	of	IN
cord-016187-58rqc0cg	277	75	drug	drug	NN
cord-016187-58rqc0cg	277	76	action	action	NN
cord-016187-58rqc0cg	277	77	and	and	CC
cord-016187-58rqc0cg	277	78	bacterial	bacterial	JJ
cord-016187-58rqc0cg	277	79	resistance	resistance	NN
cord-016187-58rqc0cg	277	80	Sulfonamide	Sulfonamide	NNP
cord-016187-58rqc0cg	277	81	resistance	resistance	NN
cord-016187-58rqc0cg	277	82	in	in	IN
cord-016187-58rqc0cg	277	83	Haemophilus	haemophilus	JJ
cord-016187-58rqc0cg	277	84	infl	infl	NN
cord-016187-58rqc0cg	277	85	uenzae	uenzae	NN
cord-016187-58rqc0cg	277	86	mediated	mediate	VBN
cord-016187-58rqc0cg	277	87	by	by	IN
cord-016187-58rqc0cg	277	88	acquisition	acquisition	NN
cord-016187-58rqc0cg	277	89	of	of	IN
cord-016187-58rqc0cg	277	90	sul2	sul2	NN
cord-016187-58rqc0cg	277	91	or	or	CC
cord-016187-58rqc0cg	277	92	a	a	DT
cord-016187-58rqc0cg	277	93	short	short	JJ
cord-016187-58rqc0cg	277	94	insertion	insertion	NN
cord-016187-58rqc0cg	277	95	in	in	IN
cord-016187-58rqc0cg	277	96	chromosomal	chromosomal	JJ
cord-016187-58rqc0cg	277	97	folP	folP	NNS
cord-016187-58rqc0cg	277	98	Trimethoprim	Trimethoprim	NNP
cord-016187-58rqc0cg	277	99	resistance	resistance	NN
cord-016187-58rqc0cg	277	100	High	high	JJ
cord-016187-58rqc0cg	277	101	-	-	HYPH
cord-016187-58rqc0cg	277	102	level	level	NN
cord-016187-58rqc0cg	277	103	tetracycline	tetracycline	NN
cord-016187-58rqc0cg	277	104	resistance	resistance	NN
cord-016187-58rqc0cg	277	105	in	in	IN
cord-016187-58rqc0cg	277	106	Neisseria	Neisseria	NNP
cord-016187-58rqc0cg	277	107	gonorrhoeae	gonorrhoeae	NNP
cord-016187-58rqc0cg	277	108	is	be	VBZ
cord-016187-58rqc0cg	277	109	result	result	NN
cord-016187-58rqc0cg	277	110	of	of	IN
cord-016187-58rqc0cg	277	111	acquisition	acquisition	NN
cord-016187-58rqc0cg	277	112	of	of	IN
cord-016187-58rqc0cg	277	113	streptococcal	streptococcal	JJ
cord-016187-58rqc0cg	277	114	tetM	tetm	JJ
cord-016187-58rqc0cg	277	115	determinant	determinant	NN
cord-016187-58rqc0cg	277	116	Phenotypic	Phenotypic	NNP
cord-016187-58rqc0cg	277	117	switching	switching	NN
cord-016187-58rqc0cg	277	118	of	of	IN
cord-016187-58rqc0cg	277	119	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	277	120	resistance	resistance	NN
cord-016187-58rqc0cg	277	121	circumvents	circumvent	VBZ
cord-016187-58rqc0cg	277	122	permanent	permanent	JJ
cord-016187-58rqc0cg	277	123	costs	cost	NNS
cord-016187-58rqc0cg	277	124	in	in	IN
cord-016187-58rqc0cg	277	125	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	277	126	aureus	aureus	NN
cord-016187-58rqc0cg	277	127	Plasmid	Plasmid	NNP
cord-016187-58rqc0cg	277	128	-	-	HYPH
cord-016187-58rqc0cg	277	129	determined	determine	VBN
cord-016187-58rqc0cg	277	130	resistance	resistance	NN
cord-016187-58rqc0cg	277	131	to	to	IN
cord-016187-58rqc0cg	277	132	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	277	133	drugs	drug	NNS
cord-016187-58rqc0cg	277	134	and	and	CC
cord-016187-58rqc0cg	277	135	toxic	toxic	JJ
cord-016187-58rqc0cg	277	136	metal	metal	NN
cord-016187-58rqc0cg	277	137	ions	ion	NNS
cord-016187-58rqc0cg	277	138	in	in	IN
cord-016187-58rqc0cg	277	139	bacteria	bacteria	NNS
cord-016187-58rqc0cg	278	1	Conjugative	conjugative	JJ
cord-016187-58rqc0cg	278	2	transfer	transfer	NN
cord-016187-58rqc0cg	278	3	of	of	IN
cord-016187-58rqc0cg	278	4	staphylococcal	staphylococcal	JJ
cord-016187-58rqc0cg	278	5	antibiotic	antibiotic	JJ
cord-016187-58rqc0cg	278	6	resistance	resistance	NN
cord-016187-58rqc0cg	278	7	markers	marker	NNS
cord-016187-58rqc0cg	278	8	in	in	IN
cord-016187-58rqc0cg	278	9	the	the	DT
cord-016187-58rqc0cg	278	10	absence	absence	NN
cord-016187-58rqc0cg	278	11	of	of	IN
cord-016187-58rqc0cg	278	12	detectable	detectable	JJ
cord-016187-58rqc0cg	278	13	plasmid	plasmid	NN
cord-016187-58rqc0cg	278	14	DNA	DNA	NNP
cord-016187-58rqc0cg	278	15	Dispersal	Dispersal	NNP
cord-016187-58rqc0cg	278	16	in	in	IN
cord-016187-58rqc0cg	278	17	Campylobacter	Campylobacter	NNP
cord-016187-58rqc0cg	278	18	spp	spp	NNS
cord-016187-58rqc0cg	278	19	.	.	.
cord-016187-58rqc0cg	279	1	of	of	IN
cord-016187-58rqc0cg	279	2	aphA-3	aphA-3	NNP
cord-016187-58rqc0cg	279	3	,	,	,
cord-016187-58rqc0cg	279	4	a	a	DT
cord-016187-58rqc0cg	279	5	kanamycin	kanamycin	NNP
cord-016187-58rqc0cg	279	6	resistance	resistance	NN
cord-016187-58rqc0cg	279	7	determinant	determinant	NN
cord-016187-58rqc0cg	279	8	from	from	IN
cord-016187-58rqc0cg	279	9	gram	gram	NN
cord-016187-58rqc0cg	279	10	-	-	HYPH
cord-016187-58rqc0cg	279	11	positive	positive	JJ
cord-016187-58rqc0cg	279	12	cocci	coccus	NNS
cord-016187-58rqc0cg	279	13	Origins	Origins	NNPS
cord-016187-58rqc0cg	279	14	of	of	IN
cord-016187-58rqc0cg	279	15	the	the	DT
cord-016187-58rqc0cg	279	16	mobile	mobile	JJ
cord-016187-58rqc0cg	279	17	gene	gene	NN
cord-016187-58rqc0cg	279	18	cassettes	cassette	NNS
cord-016187-58rqc0cg	279	19	found	find	VBN
cord-016187-58rqc0cg	279	20	in	in	IN
cord-016187-58rqc0cg	279	21	integrons	integron	NNS
cord-016187-58rqc0cg	279	22	Multidrug	Multidrug	NNP
cord-016187-58rqc0cg	279	23	resistance	resistance	NN
cord-016187-58rqc0cg	279	24	among	among	IN
cord-016187-58rqc0cg	279	25	enterobacteriaceae	enterobacteriaceae	NNS
cord-016187-58rqc0cg	279	26	is	be	VBZ
cord-016187-58rqc0cg	279	27	strongly	strongly	RB
cord-016187-58rqc0cg	279	28	associated	associate	VBN
cord-016187-58rqc0cg	279	29	with	with	IN
cord-016187-58rqc0cg	279	30	the	the	DT
cord-016187-58rqc0cg	279	31	presence	presence	NN
cord-016187-58rqc0cg	279	32	of	of	IN
cord-016187-58rqc0cg	279	33	integrons	integron	NNS
cord-016187-58rqc0cg	279	34	and	and	CC
cord-016187-58rqc0cg	279	35	is	be	VBZ
cord-016187-58rqc0cg	279	36	independent	independent	JJ
cord-016187-58rqc0cg	279	37	of	of	IN
cord-016187-58rqc0cg	279	38	species	specie	NNS
cord-016187-58rqc0cg	279	39	or	or	CC
cord-016187-58rqc0cg	279	40	isolate	isolate	VB
cord-016187-58rqc0cg	279	41	origin	origin	NN
cord-016187-58rqc0cg	279	42	Trends	trend	NNS
cord-016187-58rqc0cg	279	43	in	in	IN
cord-016187-58rqc0cg	279	44	antimicrobial	antimicrobial	JJ
cord-016187-58rqc0cg	279	45	drug	drug	NN
cord-016187-58rqc0cg	279	46	development	development	NN
cord-016187-58rqc0cg	279	47	Antibiotics	antibiotic	NNS
cord-016187-58rqc0cg	279	48	at	at	IN
cord-016187-58rqc0cg	279	49	the	the	DT
cord-016187-58rqc0cg	279	50	crossroads	crossroads	NNP
cord-016187-58rqc0cg	279	51	Safety	Safety	NNP
cord-016187-58rqc0cg	279	52	and	and	CC
cord-016187-58rqc0cg	279	53	antigenicity	antigenicity	NN
cord-016187-58rqc0cg	279	54	of	of	IN
cord-016187-58rqc0cg	279	55	non	non	JJ
cord-016187-58rqc0cg	279	56	-	-	JJ
cord-016187-58rqc0cg	279	57	adjuvanted	adjuvanted	JJ
cord-016187-58rqc0cg	279	58	and	and	CC
cord-016187-58rqc0cg	279	59	MF59-adjuvanted	mf59-adjuvanted	JJ
cord-016187-58rqc0cg	279	60	infl	infl	XX
cord-016187-58rqc0cg	279	61	uenza	uenza	NNP
cord-016187-58rqc0cg	279	62	A	A	NNP
cord-016187-58rqc0cg	279	63	/	/	SYM
cord-016187-58rqc0cg	279	64	Duck	Duck	NNP
cord-016187-58rqc0cg	279	65	/	/	SYM
cord-016187-58rqc0cg	279	66	Singapore/97	Singapore/97	NNP
cord-016187-58rqc0cg	279	67	(	(	-LRB-
cord-016187-58rqc0cg	279	68	H5N3	H5N3	NNP
cord-016187-58rqc0cg	279	69	)	)	-RRB-
cord-016187-58rqc0cg	279	70	vaccine	vaccine	NN
cord-016187-58rqc0cg	279	71	;	;	:
cord-016187-58rqc0cg	279	72	a	a	DT
cord-016187-58rqc0cg	279	73	randomized	randomized	JJ
cord-016187-58rqc0cg	279	74	trial	trial	NN
cord-016187-58rqc0cg	279	75	of	of	IN
cord-016187-58rqc0cg	279	76	two	two	CD
cord-016187-58rqc0cg	279	77	potential	potential	JJ
cord-016187-58rqc0cg	279	78	vaccines	vaccine	NNS
cord-016187-58rqc0cg	279	79	against	against	IN
cord-016187-58rqc0cg	279	80	H5N1	H5N1	NNP
cord-016187-58rqc0cg	279	81	infl	infl	NN
cord-016187-58rqc0cg	279	82	uenza	uenza	NNP
cord-016187-58rqc0cg	279	83	Antibody	Antibody	NNP
cord-016187-58rqc0cg	279	84	concentration	concentration	NN
cord-016187-58rqc0cg	279	85	and	and	CC
cord-016187-58rqc0cg	279	86	clinical	clinical	JJ
cord-016187-58rqc0cg	279	87	protection	protection	NN
cord-016187-58rqc0cg	279	88	after	after	IN
cord-016187-58rqc0cg	279	89	Hib	Hib	NNP
cord-016187-58rqc0cg	279	90	conjugate	conjugate	NN
cord-016187-58rqc0cg	279	91	vaccination	vaccination	NN
cord-016187-58rqc0cg	279	92	in	in	IN
cord-016187-58rqc0cg	279	93	the	the	DT
cord-016187-58rqc0cg	279	94	United	United	NNP
cord-016187-58rqc0cg	279	95	Kingdom	Kingdom	NNP
cord-016187-58rqc0cg	279	96	Immunogenicity	Immunogenicity	NNP
cord-016187-58rqc0cg	279	97	and	and	CC
cord-016187-58rqc0cg	279	98	impact	impact	NN
cord-016187-58rqc0cg	279	99	on	on	IN
cord-016187-58rqc0cg	279	100	nasopharyngeal	nasopharyngeal	JJ
cord-016187-58rqc0cg	279	101	carriage	carriage	NN
cord-016187-58rqc0cg	279	102	of	of	IN
cord-016187-58rqc0cg	279	103	a	a	DT
cord-016187-58rqc0cg	279	104	nonavalent	nonavalent	JJ
cord-016187-58rqc0cg	279	105	pneumococcal	pneumococcal	JJ
cord-016187-58rqc0cg	279	106	conjugate	conjugate	NN
cord-016187-58rqc0cg	279	107	vaccine	vaccine	NN
cord-016187-58rqc0cg	279	108	Antimicrobial	Antimicrobial	NNP
cord-016187-58rqc0cg	279	109	resistance	resistance	NN
cord-016187-58rqc0cg	279	110	:	:	:
cord-016187-58rqc0cg	279	111	the	the	DT
cord-016187-58rqc0cg	279	112	example	example	NN
cord-016187-58rqc0cg	279	113	of	of	IN
cord-016187-58rqc0cg	279	114	Staphylococcus	Staphylococcus	NNP
cord-016187-58rqc0cg	279	115	aureus	aureus	NN