id sid tid token lemma pos cord-011310-fm578rm5 1 1 key key NNP cord-011310-fm578rm5 1 2 : : : cord-011310-fm578rm5 1 3 cord-011310-fm578rm5 cord-011310-fm578rm5 . cord-011310-fm578rm5 2 1 authors author NNS cord-011310-fm578rm5 2 2 : : : cord-011310-fm578rm5 2 3 Leja Leja NNP cord-011310-fm578rm5 2 4 , , , cord-011310-fm578rm5 2 5 Mārcis Mārcis NNP cord-011310-fm578rm5 2 6 ; ; : cord-011310-fm578rm5 2 7 Dumpis Dumpis NNP cord-011310-fm578rm5 2 8 , , , cord-011310-fm578rm5 2 9 Uga Uga NNP cord-011310-fm578rm5 2 10 title title NN cord-011310-fm578rm5 2 11 : : : cord-011310-fm578rm5 3 1 What what WP cord-011310-fm578rm5 3 2 Would Would MD cord-011310-fm578rm5 3 3 the the DT cord-011310-fm578rm5 3 4 Screen screen NN cord-011310-fm578rm5 3 5 - - HYPH cord-011310-fm578rm5 3 6 and and CC cord-011310-fm578rm5 3 7 - - HYPH cord-011310-fm578rm5 3 8 Treat Treat NNP cord-011310-fm578rm5 3 9 Strategy Strategy NNP cord-011310-fm578rm5 3 10 for for IN cord-011310-fm578rm5 3 11 Helicobacter Helicobacter NNP cord-011310-fm578rm5 3 12 pylori pylori NN cord-011310-fm578rm5 4 1 Mean mean VB cord-011310-fm578rm5 4 2 in in IN cord-011310-fm578rm5 4 3 Terms term NNS cord-011310-fm578rm5 4 4 of of IN cord-011310-fm578rm5 4 5 Antibiotic antibiotic JJ cord-011310-fm578rm5 4 6 Consumption consumption NN cord-011310-fm578rm5 4 7 ? ? . cord-011310-fm578rm5 5 1 date date NN cord-011310-fm578rm5 5 2 : : : cord-011310-fm578rm5 5 3 2019 2019 CD cord-011310-fm578rm5 5 4 - - SYM cord-011310-fm578rm5 5 5 10 10 CD cord-011310-fm578rm5 5 6 - - SYM cord-011310-fm578rm5 5 7 28 28 CD cord-011310-fm578rm5 5 8 journal journal NN cord-011310-fm578rm5 5 9 : : : cord-011310-fm578rm5 6 1 Dig dig VB cord-011310-fm578rm5 6 2 Dis Dis NNP cord-011310-fm578rm5 6 3 Sci Sci NNP cord-011310-fm578rm5 6 4 DOI DOI NNP cord-011310-fm578rm5 6 5 : : : cord-011310-fm578rm5 6 6 10.1007 10.1007 CD cord-011310-fm578rm5 6 7 / / SYM cord-011310-fm578rm5 6 8 s10620 s10620 NN cord-011310-fm578rm5 6 9 - - HYPH cord-011310-fm578rm5 6 10 019 019 CD cord-011310-fm578rm5 6 11 - - HYPH cord-011310-fm578rm5 6 12 05893-z 05893-z NNP cord-011310-fm578rm5 6 13 sha sha NNP cord-011310-fm578rm5 6 14 : : : cord-011310-fm578rm5 7 1 a93f7f2e7341b30b8fec646dfedb22668822aa83 a93f7f2e7341b30b8fec646dfedb22668822aa83 NFP cord-011310-fm578rm5 7 2 doc_id doc_id CD cord-011310-fm578rm5 7 3 : : : cord-011310-fm578rm5 8 1 11310 11310 CD cord-011310-fm578rm5 8 2 cord_uid cord_uid NNS cord-011310-fm578rm5 8 3 : : : cord-011310-fm578rm5 9 1 fm578rm5 fm578rm5 UH cord-011310-fm578rm5 10 1 Several several JJ cord-011310-fm578rm5 10 2 guidelines guideline NNS cord-011310-fm578rm5 10 3 recommend recommend VBP cord-011310-fm578rm5 10 4 the the DT cord-011310-fm578rm5 10 5 screen screen NN cord-011310-fm578rm5 10 6 - - HYPH cord-011310-fm578rm5 10 7 and and CC cord-011310-fm578rm5 10 8 - - HYPH cord-011310-fm578rm5 10 9 treat treat VB cord-011310-fm578rm5 10 10 strategy strategy NN cord-011310-fm578rm5 10 11 , , , cord-011310-fm578rm5 10 12 i.e. i.e. FW cord-011310-fm578rm5 10 13 active active JJ cord-011310-fm578rm5 10 14 search search NN cord-011310-fm578rm5 10 15 for for IN cord-011310-fm578rm5 10 16 the the DT cord-011310-fm578rm5 10 17 presence presence NN cord-011310-fm578rm5 10 18 of of IN cord-011310-fm578rm5 10 19 Helicobacter Helicobacter NNP cord-011310-fm578rm5 10 20 pylori pylori NN cord-011310-fm578rm5 10 21 infection infection NN cord-011310-fm578rm5 10 22 and and CC cord-011310-fm578rm5 10 23 its -PRON- PRP$ cord-011310-fm578rm5 10 24 eradication eradication NN cord-011310-fm578rm5 10 25 to to TO cord-011310-fm578rm5 10 26 prevent prevent VB cord-011310-fm578rm5 10 27 the the DT cord-011310-fm578rm5 10 28 possibility possibility NN cord-011310-fm578rm5 10 29 of of IN cord-011310-fm578rm5 10 30 gastric gastric JJ cord-011310-fm578rm5 10 31 cancer cancer NN cord-011310-fm578rm5 10 32 . . . cord-011310-fm578rm5 11 1 It -PRON- PRP cord-011310-fm578rm5 11 2 is be VBZ cord-011310-fm578rm5 11 3 thought think VBN cord-011310-fm578rm5 11 4 that that IN cord-011310-fm578rm5 11 5 a a DT cord-011310-fm578rm5 11 6 relatively relatively RB cord-011310-fm578rm5 11 7 short short JJ cord-011310-fm578rm5 11 8 duration duration NN cord-011310-fm578rm5 11 9 antibiotic antibiotic JJ cord-011310-fm578rm5 11 10 regimen regimen NN cord-011310-fm578rm5 11 11 given give VBN cord-011310-fm578rm5 11 12 once once RB cord-011310-fm578rm5 11 13 in in IN cord-011310-fm578rm5 11 14 a a DT cord-011310-fm578rm5 11 15 lifetime lifetime NN cord-011310-fm578rm5 11 16 would would MD cord-011310-fm578rm5 11 17 not not RB cord-011310-fm578rm5 11 18 significantly significantly RB cord-011310-fm578rm5 11 19 increase increase VB cord-011310-fm578rm5 11 20 overall overall JJ cord-011310-fm578rm5 11 21 antibiotic antibiotic JJ cord-011310-fm578rm5 11 22 consumption consumption NN cord-011310-fm578rm5 11 23 . . . cord-011310-fm578rm5 12 1 However however RB cord-011310-fm578rm5 12 2 , , , cord-011310-fm578rm5 12 3 this this DT cord-011310-fm578rm5 12 4 would would MD cord-011310-fm578rm5 12 5 mean mean VB cord-011310-fm578rm5 12 6 offering offer VBG cord-011310-fm578rm5 12 7 antibiotic antibiotic JJ cord-011310-fm578rm5 12 8 treatment treatment NN cord-011310-fm578rm5 12 9 to to IN cord-011310-fm578rm5 12 10 the the DT cord-011310-fm578rm5 12 11 majority majority NN cord-011310-fm578rm5 12 12 of of IN cord-011310-fm578rm5 12 13 the the DT cord-011310-fm578rm5 12 14 population population NN cord-011310-fm578rm5 12 15 in in IN cord-011310-fm578rm5 12 16 countries country NNS cord-011310-fm578rm5 12 17 with with IN cord-011310-fm578rm5 12 18 the the DT cord-011310-fm578rm5 12 19 biggest big JJS cord-011310-fm578rm5 12 20 burden burden NN cord-011310-fm578rm5 12 21 of of IN cord-011310-fm578rm5 12 22 gastric gastric JJ cord-011310-fm578rm5 12 23 cancer cancer NN cord-011310-fm578rm5 12 24 who who WP cord-011310-fm578rm5 12 25 would would MD cord-011310-fm578rm5 12 26 , , , cord-011310-fm578rm5 12 27 therefore therefore RB cord-011310-fm578rm5 12 28 , , , cord-011310-fm578rm5 12 29 have have VBP cord-011310-fm578rm5 12 30 the the DT cord-011310-fm578rm5 12 31 greatest great JJS cord-011310-fm578rm5 12 32 benefit benefit NN cord-011310-fm578rm5 12 33 from from IN cord-011310-fm578rm5 12 34 such such PDT cord-011310-fm578rm5 12 35 a a DT cord-011310-fm578rm5 12 36 strategy strategy NN cord-011310-fm578rm5 12 37 . . . cord-011310-fm578rm5 13 1 So so RB cord-011310-fm578rm5 13 2 far far RB cord-011310-fm578rm5 13 3 , , , cord-011310-fm578rm5 13 4 no no DT cord-011310-fm578rm5 13 5 country country NN cord-011310-fm578rm5 13 6 has have VBZ cord-011310-fm578rm5 13 7 implemented implement VBN cord-011310-fm578rm5 13 8 an an DT cord-011310-fm578rm5 13 9 eradication eradication NN cord-011310-fm578rm5 13 10 strategy strategy NN cord-011310-fm578rm5 13 11 . . . cord-011310-fm578rm5 14 1 With with IN cord-011310-fm578rm5 14 2 an an DT cord-011310-fm578rm5 14 3 example example NN cord-011310-fm578rm5 14 4 based base VBN cord-011310-fm578rm5 14 5 on on IN cord-011310-fm578rm5 14 6 the the DT cord-011310-fm578rm5 14 7 current current JJ cord-011310-fm578rm5 14 8 situation situation NN cord-011310-fm578rm5 14 9 in in IN cord-011310-fm578rm5 14 10 Latvia Latvia NNP cord-011310-fm578rm5 14 11 , , , cord-011310-fm578rm5 14 12 we -PRON- PRP cord-011310-fm578rm5 14 13 have have VBP cord-011310-fm578rm5 14 14 estimated estimate VBN cord-011310-fm578rm5 14 15 the the DT cord-011310-fm578rm5 14 16 increase increase NN cord-011310-fm578rm5 14 17 in in IN cord-011310-fm578rm5 14 18 antibiotic antibiotic JJ cord-011310-fm578rm5 14 19 consumption consumption NN cord-011310-fm578rm5 14 20 if if IN cord-011310-fm578rm5 14 21 the the DT cord-011310-fm578rm5 14 22 screen screen NN cord-011310-fm578rm5 14 23 - - HYPH cord-011310-fm578rm5 14 24 and and CC cord-011310-fm578rm5 14 25 - - HYPH cord-011310-fm578rm5 14 26 treat treat VB cord-011310-fm578rm5 14 27 strategy strategy NN cord-011310-fm578rm5 14 28 was be VBD cord-011310-fm578rm5 14 29 applied apply VBN cord-011310-fm578rm5 14 30 . . . cord-011310-fm578rm5 15 1 Depending depend VBG cord-011310-fm578rm5 15 2 on on IN cord-011310-fm578rm5 15 3 the the DT cord-011310-fm578rm5 15 4 scenario scenario NN cord-011310-fm578rm5 15 5 that that WDT cord-011310-fm578rm5 15 6 might may MD cord-011310-fm578rm5 15 7 be be VB cord-011310-fm578rm5 15 8 chosen choose VBN cord-011310-fm578rm5 15 9 , , , cord-011310-fm578rm5 15 10 clarithromycin clarithromycin NNS cord-011310-fm578rm5 15 11 consumption consumption NN cord-011310-fm578rm5 15 12 would would MD cord-011310-fm578rm5 15 13 increase increase VB cord-011310-fm578rm5 15 14 up up RP cord-011310-fm578rm5 15 15 to to IN cord-011310-fm578rm5 15 16 sixfold sixfold VB cord-011310-fm578rm5 15 17 , , , cord-011310-fm578rm5 15 18 and and CC cord-011310-fm578rm5 15 19 amoxicillin amoxicillin JJ cord-011310-fm578rm5 15 20 consumption consumption NN cord-011310-fm578rm5 15 21 would would MD cord-011310-fm578rm5 15 22 double double VB cord-011310-fm578rm5 15 23 if if IN cord-011310-fm578rm5 15 24 the the DT cord-011310-fm578rm5 15 25 recommendations recommendation NNS cord-011310-fm578rm5 15 26 of of IN cord-011310-fm578rm5 15 27 the the DT cord-011310-fm578rm5 15 28 current current JJ cord-011310-fm578rm5 15 29 guideline guideline NN cord-011310-fm578rm5 15 30 in in IN cord-011310-fm578rm5 15 31 the the DT cord-011310-fm578rm5 15 32 local local JJ cord-011310-fm578rm5 15 33 circumstances circumstance NNS cord-011310-fm578rm5 15 34 was be VBD cord-011310-fm578rm5 15 35 applied apply VBN cord-011310-fm578rm5 15 36 . . . cord-011310-fm578rm5 16 1 It -PRON- PRP cord-011310-fm578rm5 16 2 appears appear VBZ cord-011310-fm578rm5 16 3 that that IN cord-011310-fm578rm5 16 4 an an DT cord-011310-fm578rm5 16 5 increase increase NN cord-011310-fm578rm5 16 6 in in IN cord-011310-fm578rm5 16 7 commonly commonly RB cord-011310-fm578rm5 16 8 used use VBN cord-011310-fm578rm5 16 9 antibiotic antibiotic JJ cord-011310-fm578rm5 16 10 consumption consumption NN cord-011310-fm578rm5 16 11 can can MD cord-011310-fm578rm5 16 12 not not RB cord-011310-fm578rm5 16 13 be be VB cord-011310-fm578rm5 16 14 justified justify VBN cord-011310-fm578rm5 16 15 from from IN cord-011310-fm578rm5 16 16 the the DT cord-011310-fm578rm5 16 17 viewpoint viewpoint NN cord-011310-fm578rm5 16 18 of of IN cord-011310-fm578rm5 16 19 antibiotic antibiotic JJ cord-011310-fm578rm5 16 20 stewardship stewardship NN cord-011310-fm578rm5 16 21 policies policy NNS cord-011310-fm578rm5 16 22 . . . cord-011310-fm578rm5 17 1 Solutions solution NNS cord-011310-fm578rm5 17 2 to to IN cord-011310-fm578rm5 17 3 this this DT cord-011310-fm578rm5 17 4 problem problem NN cord-011310-fm578rm5 17 5 could could MD cord-011310-fm578rm5 17 6 be be VB cord-011310-fm578rm5 17 7 the the DT cord-011310-fm578rm5 17 8 use use NN cord-011310-fm578rm5 17 9 of of IN cord-011310-fm578rm5 17 10 antibiotics antibiotic NNS cord-011310-fm578rm5 17 11 that that WDT cord-011310-fm578rm5 17 12 are be VBP cord-011310-fm578rm5 17 13 not not RB cord-011310-fm578rm5 17 14 required require VBN cord-011310-fm578rm5 17 15 for for IN cord-011310-fm578rm5 17 16 treating treat VBG cord-011310-fm578rm5 17 17 life life NN cord-011310-fm578rm5 17 18 - - HYPH cord-011310-fm578rm5 17 19 threatening threaten VBG cord-011310-fm578rm5 17 20 diseases disease NNS cord-011310-fm578rm5 17 21 or or CC cord-011310-fm578rm5 17 22 more more RBR cord-011310-fm578rm5 17 23 narrow narrow JJ cord-011310-fm578rm5 17 24 selection selection NN cord-011310-fm578rm5 17 25 of of IN cord-011310-fm578rm5 17 26 the the DT cord-011310-fm578rm5 17 27 target target NN cord-011310-fm578rm5 17 28 group group NN cord-011310-fm578rm5 17 29 , , , cord-011310-fm578rm5 17 30 e.g. e.g. DT cord-011310-fm578rm5 17 31 young young JJ cord-011310-fm578rm5 17 32 people people NNS cord-011310-fm578rm5 17 33 before before IN cord-011310-fm578rm5 17 34 family family NN cord-011310-fm578rm5 17 35 planning plan VBG cord-011310-fm578rm5 17 36 to to TO cord-011310-fm578rm5 17 37 avoid avoid VB cord-011310-fm578rm5 17 38 transmission transmission NN cord-011310-fm578rm5 17 39 to to IN cord-011310-fm578rm5 17 40 offspring offspring NN cord-011310-fm578rm5 17 41 . . . cord-011310-fm578rm5 18 1 Additional additional JJ cord-011310-fm578rm5 18 2 costs cost NNS cord-011310-fm578rm5 18 3 related relate VBN cord-011310-fm578rm5 18 4 to to IN cord-011310-fm578rm5 18 5 the the DT cord-011310-fm578rm5 18 6 increase increase NN cord-011310-fm578rm5 18 7 in in IN cord-011310-fm578rm5 18 8 resistome resistome NNP cord-011310-fm578rm5 18 9 should should MD cord-011310-fm578rm5 18 10 be be VB cord-011310-fm578rm5 18 11 considered consider VBN cord-011310-fm578rm5 18 12 for for IN cord-011310-fm578rm5 18 13 future future JJ cord-011310-fm578rm5 18 14 cost cost NN cord-011310-fm578rm5 18 15 - - HYPH cord-011310-fm578rm5 18 16 effectiveness effectiveness NN cord-011310-fm578rm5 18 17 modelling modelling NN cord-011310-fm578rm5 18 18 of of IN cord-011310-fm578rm5 18 19 the the DT cord-011310-fm578rm5 18 20 screen screen NN cord-011310-fm578rm5 18 21 - - HYPH cord-011310-fm578rm5 18 22 and and CC cord-011310-fm578rm5 18 23 - - HYPH cord-011310-fm578rm5 18 24 treat treat VB cord-011310-fm578rm5 18 25 strategy strategy NN cord-011310-fm578rm5 18 26 . . . cord-011310-fm578rm5 19 1 Although although IN cord-011310-fm578rm5 19 2 declining decline VBG cord-011310-fm578rm5 19 3 in in IN cord-011310-fm578rm5 19 4 incidence incidence NN cord-011310-fm578rm5 19 5 , , , cord-011310-fm578rm5 19 6 gastric gastric JJ cord-011310-fm578rm5 19 7 cancer cancer NN cord-011310-fm578rm5 19 8 will will MD cord-011310-fm578rm5 19 9 remain remain VB cord-011310-fm578rm5 19 10 an an DT cord-011310-fm578rm5 19 11 important important JJ cord-011310-fm578rm5 19 12 healthcare healthcare NN cord-011310-fm578rm5 19 13 issue issue NN cord-011310-fm578rm5 19 14 for for IN cord-011310-fm578rm5 19 15 the the DT cord-011310-fm578rm5 19 16 foreseeable foreseeable JJ cord-011310-fm578rm5 19 17 future future NN cord-011310-fm578rm5 19 18 due due JJ cord-011310-fm578rm5 19 19 to to IN cord-011310-fm578rm5 19 20 aging age VBG cord-011310-fm578rm5 19 21 and and CC cord-011310-fm578rm5 19 22 the the DT cord-011310-fm578rm5 19 23 increase increase NN cord-011310-fm578rm5 19 24 in in IN cord-011310-fm578rm5 19 25 global global JJ cord-011310-fm578rm5 19 26 population population NN cord-011310-fm578rm5 19 27 . . . cord-011310-fm578rm5 20 1 The the DT cord-011310-fm578rm5 20 2 group group NN cord-011310-fm578rm5 20 3 of of IN cord-011310-fm578rm5 20 4 experts expert NNS cord-011310-fm578rm5 20 5 gathered gather VBN cord-011310-fm578rm5 20 6 by by IN cord-011310-fm578rm5 20 7 the the DT cord-011310-fm578rm5 20 8 International International NNP cord-011310-fm578rm5 20 9 Agency Agency NNP cord-011310-fm578rm5 20 10 for for IN cord-011310-fm578rm5 20 11 Research Research NNP cord-011310-fm578rm5 20 12 on on IN cord-011310-fm578rm5 20 13 Cancer Cancer NNP cord-011310-fm578rm5 20 14 ( ( -LRB- cord-011310-fm578rm5 20 15 IARC IARC NNP cord-011310-fm578rm5 20 16 ) ) -RRB- cord-011310-fm578rm5 20 17 has have VBZ cord-011310-fm578rm5 20 18 suggested suggest VBN cord-011310-fm578rm5 20 19 implementation implementation NN cord-011310-fm578rm5 20 20 of of IN cord-011310-fm578rm5 20 21 gastric gastric JJ cord-011310-fm578rm5 20 22 cancer cancer NN cord-011310-fm578rm5 20 23 prevention prevention NN cord-011310-fm578rm5 20 24 by by IN cord-011310-fm578rm5 20 25 Helicobacter Helicobacter NNP cord-011310-fm578rm5 20 26 pylori pylori NN cord-011310-fm578rm5 21 1 ( ( -LRB- cord-011310-fm578rm5 21 2 H. H. NNP cord-011310-fm578rm5 21 3 pylori pylori NN cord-011310-fm578rm5 21 4 ) ) -RRB- cord-011310-fm578rm5 21 5 eradication eradication NN cord-011310-fm578rm5 21 6 in in IN cord-011310-fm578rm5 21 7 well well RB cord-011310-fm578rm5 21 8 - - HYPH cord-011310-fm578rm5 21 9 controlled control VBN cord-011310-fm578rm5 21 10 research research NN cord-011310-fm578rm5 21 11 settings setting NNS cord-011310-fm578rm5 21 12 ( ( -LRB- cord-011310-fm578rm5 21 13 ML ML NNP cord-011310-fm578rm5 21 14 was be VBD cord-011310-fm578rm5 21 15 part part NN cord-011310-fm578rm5 21 16 of of IN cord-011310-fm578rm5 21 17 the the DT cord-011310-fm578rm5 21 18 working work VBG cord-011310-fm578rm5 21 19 group group NN cord-011310-fm578rm5 21 20 ) ) -RRB- cord-011310-fm578rm5 22 1 [ [ -LRB- cord-011310-fm578rm5 22 2 1 1 CD cord-011310-fm578rm5 22 3 ] ] -RRB- cord-011310-fm578rm5 22 4 . . . cord-011310-fm578rm5 23 1 The the DT cord-011310-fm578rm5 23 2 annual annual JJ cord-011310-fm578rm5 23 3 total total JJ cord-011310-fm578rm5 23 4 number number NN cord-011310-fm578rm5 23 5 of of IN cord-011310-fm578rm5 23 6 new new JJ cord-011310-fm578rm5 23 7 cases case NNS cord-011310-fm578rm5 23 8 accounts account VBZ cord-011310-fm578rm5 23 9 for for IN cord-011310-fm578rm5 23 10 ~ ~ CD cord-011310-fm578rm5 23 11 one one CD cord-011310-fm578rm5 23 12 million million CD cord-011310-fm578rm5 23 13 , , , cord-011310-fm578rm5 23 14 responsible responsible JJ cord-011310-fm578rm5 23 15 for for IN cord-011310-fm578rm5 23 16 > > $ cord-011310-fm578rm5 23 17 8 8 CD cord-011310-fm578rm5 23 18 % % NN cord-011310-fm578rm5 23 19 of of IN cord-011310-fm578rm5 23 20 global global JJ cord-011310-fm578rm5 23 21 cancer cancer NN cord-011310-fm578rm5 23 22 - - HYPH cord-011310-fm578rm5 23 23 related relate VBN cord-011310-fm578rm5 23 24 deaths death NNS cord-011310-fm578rm5 23 25 each each DT cord-011310-fm578rm5 23 26 year year NN cord-011310-fm578rm5 23 27 [ [ -LRB- cord-011310-fm578rm5 23 28 2 2 CD cord-011310-fm578rm5 23 29 ] ] -RRB- cord-011310-fm578rm5 23 30 . . . cord-011310-fm578rm5 24 1 This this DT cord-011310-fm578rm5 24 2 number number NN cord-011310-fm578rm5 24 3 is be VBZ cord-011310-fm578rm5 24 4 estimated estimate VBN cord-011310-fm578rm5 24 5 to to TO cord-011310-fm578rm5 24 6 remain remain VB cord-011310-fm578rm5 24 7 stable stable JJ cord-011310-fm578rm5 24 8 for for IN cord-011310-fm578rm5 24 9 at at IN cord-011310-fm578rm5 24 10 least least JJS cord-011310-fm578rm5 24 11 the the DT cord-011310-fm578rm5 24 12 next next JJ cord-011310-fm578rm5 24 13 30 30 CD cord-011310-fm578rm5 24 14 years year NNS cord-011310-fm578rm5 24 15 if if IN cord-011310-fm578rm5 24 16 no no DT cord-011310-fm578rm5 24 17 prevention prevention NN cord-011310-fm578rm5 24 18 measures measure NNS cord-011310-fm578rm5 24 19 are be VBP cord-011310-fm578rm5 24 20 implemented implement VBN cord-011310-fm578rm5 24 21 [ [ -LRB- cord-011310-fm578rm5 24 22 3 3 CD cord-011310-fm578rm5 24 23 ] ] -RRB- cord-011310-fm578rm5 24 24 . . . cord-011310-fm578rm5 25 1 Infection infection NN cord-011310-fm578rm5 25 2 with with IN cord-011310-fm578rm5 25 3 H. H. NNP cord-011310-fm578rm5 25 4 pylori pylori NN cord-011310-fm578rm5 25 5 is be VBZ cord-011310-fm578rm5 25 6 the the DT cord-011310-fm578rm5 25 7 key key JJ cord-011310-fm578rm5 25 8 risk risk NN cord-011310-fm578rm5 25 9 factor factor NN cord-011310-fm578rm5 25 10 for for IN cord-011310-fm578rm5 25 11 this this DT cord-011310-fm578rm5 25 12 type type NN cord-011310-fm578rm5 25 13 of of IN cord-011310-fm578rm5 25 14 cancer cancer NN cord-011310-fm578rm5 25 15 , , , cord-011310-fm578rm5 25 16 responsible responsible JJ cord-011310-fm578rm5 25 17 for for IN cord-011310-fm578rm5 25 18 ~ ~ CD cord-011310-fm578rm5 25 19 90 90 CD cord-011310-fm578rm5 25 20 % % NN cord-011310-fm578rm5 25 21 of of IN cord-011310-fm578rm5 25 22 the the DT cord-011310-fm578rm5 25 23 distal distal JJ cord-011310-fm578rm5 25 24 ( ( -LRB- cord-011310-fm578rm5 25 25 non non JJ cord-011310-fm578rm5 25 26 - - JJ cord-011310-fm578rm5 25 27 cardia cardia JJ cord-011310-fm578rm5 25 28 ) ) -RRB- cord-011310-fm578rm5 25 29 cancer cancer NN cord-011310-fm578rm5 25 30 cases case NNS cord-011310-fm578rm5 25 31 [ [ -LRB- cord-011310-fm578rm5 25 32 4 4 CD cord-011310-fm578rm5 25 33 , , , cord-011310-fm578rm5 25 34 5 5 CD cord-011310-fm578rm5 25 35 ] ] -RRB- cord-011310-fm578rm5 25 36 . . . cord-011310-fm578rm5 26 1 Several several JJ cord-011310-fm578rm5 26 2 prevention prevention NN cord-011310-fm578rm5 26 3 strategies strategy NNS cord-011310-fm578rm5 26 4 , , , cord-011310-fm578rm5 26 5 including include VBG cord-011310-fm578rm5 26 6 primary primary JJ cord-011310-fm578rm5 26 7 and and CC cord-011310-fm578rm5 26 8 secondary secondary JJ cord-011310-fm578rm5 26 9 prevention prevention NN cord-011310-fm578rm5 26 10 are be VBP cord-011310-fm578rm5 26 11 suggested suggest VBN cord-011310-fm578rm5 26 12 to to TO cord-011310-fm578rm5 26 13 decrease decrease VB cord-011310-fm578rm5 26 14 the the DT cord-011310-fm578rm5 26 15 mortality mortality NN cord-011310-fm578rm5 26 16 caused cause VBN cord-011310-fm578rm5 26 17 by by IN cord-011310-fm578rm5 26 18 gastric gastric JJ cord-011310-fm578rm5 26 19 cancer cancer NN cord-011310-fm578rm5 26 20 . . . cord-011310-fm578rm5 27 1 Only only RB cord-011310-fm578rm5 27 2 about about RB cord-011310-fm578rm5 27 3 1 1 CD cord-011310-fm578rm5 27 4 - - SYM cord-011310-fm578rm5 27 5 2 2 CD cord-011310-fm578rm5 27 6 % % NN cord-011310-fm578rm5 27 7 of of IN cord-011310-fm578rm5 27 8 individuals individual NNS cord-011310-fm578rm5 27 9 infected infect VBN cord-011310-fm578rm5 27 10 with with IN cord-011310-fm578rm5 27 11 H. H. NNP cord-011310-fm578rm5 27 12 pylori pylori NN cord-011310-fm578rm5 27 13 are be VBP cord-011310-fm578rm5 27 14 likely likely JJ cord-011310-fm578rm5 27 15 to to TO cord-011310-fm578rm5 27 16 develop develop VB cord-011310-fm578rm5 27 17 gastric gastric JJ cord-011310-fm578rm5 27 18 cancer cancer NN cord-011310-fm578rm5 27 19 in in IN cord-011310-fm578rm5 27 20 their -PRON- PRP$ cord-011310-fm578rm5 27 21 lifetime lifetime NN cord-011310-fm578rm5 27 22 [ [ -LRB- cord-011310-fm578rm5 27 23 6 6 CD cord-011310-fm578rm5 27 24 , , , cord-011310-fm578rm5 27 25 7 7 CD cord-011310-fm578rm5 27 26 ] ] -RRB- cord-011310-fm578rm5 27 27 . . . cord-011310-fm578rm5 28 1 Ideally ideally RB cord-011310-fm578rm5 28 2 , , , cord-011310-fm578rm5 28 3 only only RB cord-011310-fm578rm5 28 4 the the DT cord-011310-fm578rm5 28 5 bacteria bacteria NNS cord-011310-fm578rm5 28 6 potentially potentially RB cord-011310-fm578rm5 28 7 leading lead VBG cord-011310-fm578rm5 28 8 to to IN cord-011310-fm578rm5 28 9 cancer cancer NN cord-011310-fm578rm5 28 10 or or CC cord-011310-fm578rm5 28 11 other other JJ cord-011310-fm578rm5 28 12 diseases disease NNS cord-011310-fm578rm5 28 13 should should MD cord-011310-fm578rm5 28 14 be be VB cord-011310-fm578rm5 28 15 eradicated eradicate VBN cord-011310-fm578rm5 28 16 ; ; : cord-011310-fm578rm5 28 17 however however RB cord-011310-fm578rm5 28 18 , , , cord-011310-fm578rm5 28 19 risk risk NN cord-011310-fm578rm5 28 20 stratification stratification NN cord-011310-fm578rm5 28 21 attempts attempt NNS cord-011310-fm578rm5 28 22 based base VBN cord-011310-fm578rm5 28 23 on on IN cord-011310-fm578rm5 28 24 H. h. NN cord-011310-fm578rm5 28 25 pylori pylori NN cord-011310-fm578rm5 28 26 virulence virulence NN cord-011310-fm578rm5 28 27 factor factor NN cord-011310-fm578rm5 28 28 identification identification NN cord-011310-fm578rm5 28 29 or or CC cord-011310-fm578rm5 28 30 host host NN cord-011310-fm578rm5 28 31 susceptibility susceptibility NN cord-011310-fm578rm5 28 32 , , , cord-011310-fm578rm5 28 33 e.g. e.g. RB cord-011310-fm578rm5 28 34 by by IN cord-011310-fm578rm5 28 35 detecting detect VBG cord-011310-fm578rm5 28 36 the the DT cord-011310-fm578rm5 28 37 relevant relevant JJ cord-011310-fm578rm5 28 38 polymorphisms polymorphism NNS cord-011310-fm578rm5 28 39 of of IN cord-011310-fm578rm5 28 40 proinflammatory proinflammatory JJ cord-011310-fm578rm5 28 41 cytokines cytokine NNS cord-011310-fm578rm5 28 42 , , , cord-011310-fm578rm5 28 43 have have VBP cord-011310-fm578rm5 28 44 not not RB cord-011310-fm578rm5 28 45 led lead VBN cord-011310-fm578rm5 28 46 to to IN cord-011310-fm578rm5 28 47 a a DT cord-011310-fm578rm5 28 48 strategy strategy NN cord-011310-fm578rm5 28 49 that that WDT cord-011310-fm578rm5 28 50 could could MD cord-011310-fm578rm5 28 51 be be VB cord-011310-fm578rm5 28 52 recommended recommend VBN cord-011310-fm578rm5 28 53 for for IN cord-011310-fm578rm5 28 54 routine routine JJ cord-011310-fm578rm5 28 55 practice practice NN cord-011310-fm578rm5 28 56 [ [ -LRB- cord-011310-fm578rm5 28 57 8 8 CD cord-011310-fm578rm5 28 58 ] ] -RRB- cord-011310-fm578rm5 28 59 . . . cord-011310-fm578rm5 29 1 Vaccine vaccine NN cord-011310-fm578rm5 29 2 development development NN cord-011310-fm578rm5 29 3 still still RB cord-011310-fm578rm5 29 4 does do VBZ cord-011310-fm578rm5 29 5 not not RB cord-011310-fm578rm5 29 6 provide provide VB cord-011310-fm578rm5 29 7 encouraging encouraging JJ cord-011310-fm578rm5 29 8 results result NNS cord-011310-fm578rm5 29 9 suggesting suggest VBG cord-011310-fm578rm5 29 10 that that IN cord-011310-fm578rm5 29 11 it -PRON- PRP cord-011310-fm578rm5 29 12 is be VBZ cord-011310-fm578rm5 29 13 close close JJ cord-011310-fm578rm5 29 14 to to IN cord-011310-fm578rm5 29 15 a a DT cord-011310-fm578rm5 29 16 routine routine JJ cord-011310-fm578rm5 29 17 practice practice NN cord-011310-fm578rm5 29 18 [ [ -LRB- cord-011310-fm578rm5 29 19 9 9 CD cord-011310-fm578rm5 29 20 ] ] -RRB- cord-011310-fm578rm5 29 21 . . . cord-011310-fm578rm5 30 1 Eradication eradication NN cord-011310-fm578rm5 30 2 of of IN cord-011310-fm578rm5 30 3 H. H. NNP cord-011310-fm578rm5 30 4 pylori pylori NN cord-011310-fm578rm5 30 5 in in IN cord-011310-fm578rm5 30 6 adults adult NNS cord-011310-fm578rm5 30 7 hosting host VBG cord-011310-fm578rm5 30 8 the the DT cord-011310-fm578rm5 30 9 infection infection NN cord-011310-fm578rm5 30 10 appears appear VBZ cord-011310-fm578rm5 30 11 to to TO cord-011310-fm578rm5 30 12 be be VB cord-011310-fm578rm5 30 13 the the DT cord-011310-fm578rm5 30 14 most most RBS cord-011310-fm578rm5 30 15 effective effective JJ cord-011310-fm578rm5 30 16 prevention prevention NN cord-011310-fm578rm5 30 17 strategy strategy NN cord-011310-fm578rm5 30 18 . . . cord-011310-fm578rm5 31 1 The the DT cord-011310-fm578rm5 31 2 only only JJ cord-011310-fm578rm5 31 3 reliable reliable JJ cord-011310-fm578rm5 31 4 approach approach NN cord-011310-fm578rm5 31 5 to to TO cord-011310-fm578rm5 31 6 eliminate eliminate VB cord-011310-fm578rm5 31 7 the the DT cord-011310-fm578rm5 31 8 infection infection NN cord-011310-fm578rm5 31 9 is be VBZ cord-011310-fm578rm5 31 10 simultaneous simultaneous JJ cord-011310-fm578rm5 31 11 use use NN cord-011310-fm578rm5 31 12 of of IN cord-011310-fm578rm5 31 13 at at RB cord-011310-fm578rm5 31 14 least least RBS cord-011310-fm578rm5 31 15 two two CD cord-011310-fm578rm5 31 16 different different JJ cord-011310-fm578rm5 31 17 antibiotics antibiotic NNS cord-011310-fm578rm5 31 18 in in IN cord-011310-fm578rm5 31 19 combination combination NN cord-011310-fm578rm5 31 20 with with IN cord-011310-fm578rm5 31 21 potent potent JJ cord-011310-fm578rm5 31 22 acid acid NN cord-011310-fm578rm5 31 23 suppression suppression NN cord-011310-fm578rm5 31 24 using use VBG cord-011310-fm578rm5 31 25 a a DT cord-011310-fm578rm5 31 26 proton proton NN cord-011310-fm578rm5 31 27 pump pump NN cord-011310-fm578rm5 31 28 inhibitor inhibitor NN cord-011310-fm578rm5 31 29 or or CC cord-011310-fm578rm5 31 30 a a DT cord-011310-fm578rm5 31 31 potassium potassium NN cord-011310-fm578rm5 31 32 - - HYPH cord-011310-fm578rm5 31 33 competitive competitive JJ cord-011310-fm578rm5 31 34 acid acid NN cord-011310-fm578rm5 31 35 blocker blocker NN cord-011310-fm578rm5 31 36 ( ( -LRB- cord-011310-fm578rm5 31 37 PCAB PCAB NNP cord-011310-fm578rm5 31 38 ) ) -RRB- cord-011310-fm578rm5 31 39 [ [ -LRB- cord-011310-fm578rm5 31 40 10 10 CD cord-011310-fm578rm5 31 41 ] ] -RRB- cord-011310-fm578rm5 31 42 . . . cord-011310-fm578rm5 32 1 A a DT cord-011310-fm578rm5 32 2 screen screen NN cord-011310-fm578rm5 32 3 - - HYPH cord-011310-fm578rm5 32 4 and and CC cord-011310-fm578rm5 32 5 - - HYPH cord-011310-fm578rm5 32 6 treat treat VB cord-011310-fm578rm5 32 7 strategy strategy NN cord-011310-fm578rm5 32 8 would would MD cord-011310-fm578rm5 32 9 mean mean VB cord-011310-fm578rm5 32 10 active active JJ cord-011310-fm578rm5 32 11 testing testing NN cord-011310-fm578rm5 32 12 for for IN cord-011310-fm578rm5 32 13 presence presence NN cord-011310-fm578rm5 32 14 of of IN cord-011310-fm578rm5 32 15 H. H. NNP cord-011310-fm578rm5 32 16 pylori pylori NN cord-011310-fm578rm5 32 17 in in IN cord-011310-fm578rm5 32 18 the the DT cord-011310-fm578rm5 32 19 ( ( -LRB- cord-011310-fm578rm5 32 20 mostly mostly RB cord-011310-fm578rm5 32 21 healthy healthy JJ cord-011310-fm578rm5 32 22 ) ) -RRB- cord-011310-fm578rm5 32 23 general general JJ cord-011310-fm578rm5 32 24 population population NN cord-011310-fm578rm5 32 25 , , , cord-011310-fm578rm5 32 26 and and CC cord-011310-fm578rm5 32 27 offering offer VBG cord-011310-fm578rm5 32 28 eradication eradication NN cord-011310-fm578rm5 32 29 to to IN cord-011310-fm578rm5 32 30 those those DT cord-011310-fm578rm5 32 31 testing testing NN cord-011310-fm578rm5 32 32 positive positive JJ cord-011310-fm578rm5 32 33 [ [ -LRB- cord-011310-fm578rm5 32 34 11 11 CD cord-011310-fm578rm5 32 35 ] ] -RRB- cord-011310-fm578rm5 32 36 . . . cord-011310-fm578rm5 33 1 It -PRON- PRP cord-011310-fm578rm5 33 2 is be VBZ cord-011310-fm578rm5 33 3 expected expect VBN cord-011310-fm578rm5 33 4 that that IN cord-011310-fm578rm5 33 5 H. h. NN cord-011310-fm578rm5 33 6 pylori pylori NN cord-011310-fm578rm5 33 7 eradication eradication NN cord-011310-fm578rm5 33 8 would would MD cord-011310-fm578rm5 33 9 reduce reduce VB cord-011310-fm578rm5 33 10 the the DT cord-011310-fm578rm5 33 11 risk risk NN cord-011310-fm578rm5 33 12 of of IN cord-011310-fm578rm5 33 13 gastric gastric JJ cord-011310-fm578rm5 33 14 cancer cancer NN cord-011310-fm578rm5 33 15 in in IN cord-011310-fm578rm5 33 16 the the DT cord-011310-fm578rm5 33 17 population population NN cord-011310-fm578rm5 33 18 for for IN cord-011310-fm578rm5 33 19 ~ ~ CD cord-011310-fm578rm5 33 20 34 34 CD cord-011310-fm578rm5 33 21 % % NN cord-011310-fm578rm5 33 22 [ [ -LRB- cord-011310-fm578rm5 33 23 11 11 CD cord-011310-fm578rm5 33 24 ] ] -RRB- cord-011310-fm578rm5 33 25 . . . cord-011310-fm578rm5 34 1 Such such PDT cord-011310-fm578rm5 34 2 a a DT cord-011310-fm578rm5 34 3 strategy strategy NN cord-011310-fm578rm5 34 4 should should MD cord-011310-fm578rm5 34 5 comply comply VB cord-011310-fm578rm5 34 6 with with IN cord-011310-fm578rm5 34 7 the the DT cord-011310-fm578rm5 34 8 principles principle NNS cord-011310-fm578rm5 34 9 of of IN cord-011310-fm578rm5 34 10 good good JJ cord-011310-fm578rm5 34 11 governance governance NN cord-011310-fm578rm5 34 12 and and CC cord-011310-fm578rm5 34 13 organization organization NN cord-011310-fm578rm5 34 14 , , , cord-011310-fm578rm5 34 15 and and CC cord-011310-fm578rm5 34 16 the the DT cord-011310-fm578rm5 34 17 benefits benefit NNS cord-011310-fm578rm5 34 18 should should MD cord-011310-fm578rm5 34 19 be be VB cord-011310-fm578rm5 34 20 well well RB cord-011310-fm578rm5 34 21 - - HYPH cord-011310-fm578rm5 34 22 balanced balance VBN cord-011310-fm578rm5 34 23 against against IN cord-011310-fm578rm5 34 24 the the DT cord-011310-fm578rm5 34 25 risks risk NNS cord-011310-fm578rm5 34 26 that that WDT cord-011310-fm578rm5 34 27 any any DT cord-011310-fm578rm5 34 28 potential potential JJ cord-011310-fm578rm5 34 29 intervention intervention NN cord-011310-fm578rm5 34 30 could could MD cord-011310-fm578rm5 34 31 create create VB cord-011310-fm578rm5 34 32 [ [ -LRB- cord-011310-fm578rm5 34 33 12 12 CD cord-011310-fm578rm5 34 34 ] ] -RRB- cord-011310-fm578rm5 34 35 . . . cord-011310-fm578rm5 35 1 Several several JJ cord-011310-fm578rm5 35 2 risks risk NNS cord-011310-fm578rm5 35 3 have have VBP cord-011310-fm578rm5 35 4 been be VBN cord-011310-fm578rm5 35 5 suggested suggest VBN cord-011310-fm578rm5 35 6 for for IN cord-011310-fm578rm5 35 7 population population NN cord-011310-fm578rm5 35 8 - - HYPH cord-011310-fm578rm5 35 9 based base VBN cord-011310-fm578rm5 35 10 H. h. NN cord-011310-fm578rm5 35 11 pylori pylori NN cord-011310-fm578rm5 35 12 eradication eradication NN cord-011310-fm578rm5 35 13 ; ; : cord-011310-fm578rm5 35 14 however however RB cord-011310-fm578rm5 35 15 , , , cord-011310-fm578rm5 35 16 the the DT cord-011310-fm578rm5 35 17 possible possible JJ cord-011310-fm578rm5 35 18 adverse adverse JJ cord-011310-fm578rm5 35 19 effects effect NNS cord-011310-fm578rm5 35 20 related relate VBN cord-011310-fm578rm5 35 21 to to IN cord-011310-fm578rm5 35 22 increased increase VBN cord-011310-fm578rm5 35 23 antibiotic antibiotic JJ cord-011310-fm578rm5 35 24 consumption consumption NN cord-011310-fm578rm5 35 25 probably probably RB cord-011310-fm578rm5 35 26 are be VBP cord-011310-fm578rm5 35 27 the the DT cord-011310-fm578rm5 35 28 most most RBS cord-011310-fm578rm5 35 29 significant significant JJ cord-011310-fm578rm5 35 30 . . . cord-011310-fm578rm5 36 1 Resistant resistant JJ cord-011310-fm578rm5 36 2 H. H. NNP cord-011310-fm578rm5 36 3 pylori pylori NN cord-011310-fm578rm5 36 4 strains strain NNS cord-011310-fm578rm5 36 5 are be VBP cord-011310-fm578rm5 36 6 emerging emerge VBG cord-011310-fm578rm5 36 7 due due IN cord-011310-fm578rm5 36 8 to to IN cord-011310-fm578rm5 36 9 high high JJ cord-011310-fm578rm5 36 10 antibiotic antibiotic JJ cord-011310-fm578rm5 36 11 consumption consumption NN cord-011310-fm578rm5 36 12 [ [ -LRB- cord-011310-fm578rm5 36 13 13 13 CD cord-011310-fm578rm5 36 14 ] ] -RRB- cord-011310-fm578rm5 36 15 . . . cord-011310-fm578rm5 37 1 However however RB cord-011310-fm578rm5 37 2 , , , cord-011310-fm578rm5 37 3 the the DT cord-011310-fm578rm5 37 4 most most RBS cord-011310-fm578rm5 37 5 significant significant JJ cord-011310-fm578rm5 37 6 risks risk NNS cord-011310-fm578rm5 37 7 will will MD cord-011310-fm578rm5 37 8 probably probably RB cord-011310-fm578rm5 37 9 be be VB cord-011310-fm578rm5 37 10 related relate VBN cord-011310-fm578rm5 37 11 to to IN cord-011310-fm578rm5 37 12 induction induction NN cord-011310-fm578rm5 37 13 of of IN cord-011310-fm578rm5 37 14 resistance resistance NN cord-011310-fm578rm5 37 15 in in IN cord-011310-fm578rm5 37 16 other other JJ cord-011310-fm578rm5 37 17 clinically clinically RB cord-011310-fm578rm5 37 18 relevant relevant JJ cord-011310-fm578rm5 37 19 bacteria bacteria NNS cord-011310-fm578rm5 37 20 than than IN cord-011310-fm578rm5 37 21 H. H. NNP cord-011310-fm578rm5 37 22 pylori pylori NN cord-011310-fm578rm5 37 23 and and CC cord-011310-fm578rm5 37 24 increase increase VB cord-011310-fm578rm5 37 25 the the DT cord-011310-fm578rm5 37 26 pool pool NN cord-011310-fm578rm5 37 27 of of IN cord-011310-fm578rm5 37 28 resistant resistant JJ cord-011310-fm578rm5 37 29 genes gene NNS cord-011310-fm578rm5 37 30 in in IN cord-011310-fm578rm5 37 31 the the DT cord-011310-fm578rm5 37 32 gut gut NN cord-011310-fm578rm5 37 33 and and CC cord-011310-fm578rm5 37 34 upper upper JJ cord-011310-fm578rm5 37 35 respiratory respiratory JJ cord-011310-fm578rm5 37 36 system system NN cord-011310-fm578rm5 37 37 [ [ -LRB- cord-011310-fm578rm5 37 38 14 14 CD cord-011310-fm578rm5 37 39 ] ] -RRB- cord-011310-fm578rm5 37 40 [ [ -LRB- cord-011310-fm578rm5 37 41 15 15 CD cord-011310-fm578rm5 37 42 ] ] -RRB- cord-011310-fm578rm5 37 43 [ [ -LRB- cord-011310-fm578rm5 37 44 16 16 CD cord-011310-fm578rm5 37 45 ] ] -RRB- cord-011310-fm578rm5 37 46 . . . cord-011310-fm578rm5 38 1 The the DT cord-011310-fm578rm5 38 2 currently currently RB cord-011310-fm578rm5 38 3 recommended recommend VBN cord-011310-fm578rm5 38 4 choice choice NN cord-011310-fm578rm5 38 5 of of IN cord-011310-fm578rm5 38 6 antibiotics antibiotic NNS cord-011310-fm578rm5 38 7 depends depend VBZ cord-011310-fm578rm5 38 8 on on IN cord-011310-fm578rm5 38 9 the the DT cord-011310-fm578rm5 38 10 local local JJ cord-011310-fm578rm5 38 11 resistance resistance NN cord-011310-fm578rm5 38 12 pattern pattern NN cord-011310-fm578rm5 38 13 of of IN cord-011310-fm578rm5 38 14 H. h. NN cord-011310-fm578rm5 38 15 pylori pylori NN cord-011310-fm578rm5 38 16 , , , cord-011310-fm578rm5 38 17 unless unless IN cord-011310-fm578rm5 38 18 susceptibility susceptibility NN cord-011310-fm578rm5 38 19 - - HYPH cord-011310-fm578rm5 38 20 based base VBN cord-011310-fm578rm5 38 21 individual individual JJ cord-011310-fm578rm5 38 22 therapy therapy NN cord-011310-fm578rm5 38 23 is be VBZ cord-011310-fm578rm5 38 24 prescribed prescribe VBN cord-011310-fm578rm5 38 25 [ [ -LRB- cord-011310-fm578rm5 38 26 10 10 CD cord-011310-fm578rm5 38 27 , , , cord-011310-fm578rm5 38 28 11 11 CD cord-011310-fm578rm5 38 29 ] ] -RRB- cord-011310-fm578rm5 38 30 . . . cord-011310-fm578rm5 39 1 Clarithromycin Clarithromycin NNP cord-011310-fm578rm5 39 2 and and CC cord-011310-fm578rm5 39 3 amoxicillin amoxicillin NNP cord-011310-fm578rm5 39 4 are be VBP cord-011310-fm578rm5 39 5 the the DT cord-011310-fm578rm5 39 6 most most RBS cord-011310-fm578rm5 39 7 widely widely RB cord-011310-fm578rm5 39 8 prescribed prescribe VBN cord-011310-fm578rm5 39 9 antibiotics antibiotic NNS cord-011310-fm578rm5 39 10 , , , cord-011310-fm578rm5 39 11 frequently frequently RB cord-011310-fm578rm5 39 12 used use VBN cord-011310-fm578rm5 39 13 in in IN cord-011310-fm578rm5 39 14 both both CC cord-011310-fm578rm5 39 15 low low JJ cord-011310-fm578rm5 39 16 and and CC cord-011310-fm578rm5 39 17 high high JJ cord-011310-fm578rm5 39 18 clarithromycin clarithromycin NNS cord-011310-fm578rm5 39 19 - - HYPH cord-011310-fm578rm5 39 20 resistant resistant JJ cord-011310-fm578rm5 39 21 regions region NNS cord-011310-fm578rm5 39 22 . . . cord-011310-fm578rm5 40 1 According accord VBG cord-011310-fm578rm5 40 2 to to IN cord-011310-fm578rm5 40 3 the the DT cord-011310-fm578rm5 40 4 guidelines guideline NNS cord-011310-fm578rm5 40 5 , , , cord-011310-fm578rm5 40 6 the the DT cord-011310-fm578rm5 40 7 clarithromycin clarithromycin NNP cord-011310-fm578rm5 40 8 - - HYPH cord-011310-fm578rm5 40 9 containing contain VBG cord-011310-fm578rm5 40 10 regimen regimen NN cord-011310-fm578rm5 40 11 is be VBZ cord-011310-fm578rm5 40 12 the the DT cord-011310-fm578rm5 40 13 choice choice NN cord-011310-fm578rm5 40 14 where where WRB cord-011310-fm578rm5 40 15 H. H. NNP cord-011310-fm578rm5 40 16 pylori pylori NN cord-011310-fm578rm5 40 17 is be VBZ cord-011310-fm578rm5 40 18 clearly clearly RB cord-011310-fm578rm5 40 19 sensitive sensitive JJ cord-011310-fm578rm5 40 20 to to IN cord-011310-fm578rm5 40 21 clarithromycin clarithromycin NNS cord-011310-fm578rm5 40 22 ( ( -LRB- cord-011310-fm578rm5 40 23 for for IN cord-011310-fm578rm5 40 24 individualized individualized JJ cord-011310-fm578rm5 40 25 treatment treatment NN cord-011310-fm578rm5 40 26 ) ) -RRB- cord-011310-fm578rm5 40 27 or or CC cord-011310-fm578rm5 40 28 if if IN cord-011310-fm578rm5 40 29 H. H. NNP cord-011310-fm578rm5 40 30 pylori pylori NN cord-011310-fm578rm5 40 31 resistance resistance NN cord-011310-fm578rm5 40 32 to to IN cord-011310-fm578rm5 40 33 clarithromycin clarithromycin NNP cord-011310-fm578rm5 40 34 does do VBZ cord-011310-fm578rm5 40 35 not not RB cord-011310-fm578rm5 40 36 exceed exceed VB cord-011310-fm578rm5 40 37 15 15 CD cord-011310-fm578rm5 40 38 % % NN cord-011310-fm578rm5 40 39 in in IN cord-011310-fm578rm5 40 40 the the DT cord-011310-fm578rm5 40 41 reference reference NN cord-011310-fm578rm5 40 42 population population NN cord-011310-fm578rm5 40 43 [ [ -LRB- cord-011310-fm578rm5 40 44 11 11 CD cord-011310-fm578rm5 40 45 ] ] -RRB- cord-011310-fm578rm5 40 46 . . . cord-011310-fm578rm5 41 1 Although although IN cord-011310-fm578rm5 41 2 the the DT cord-011310-fm578rm5 41 3 resistance resistance NN cord-011310-fm578rm5 41 4 of of IN cord-011310-fm578rm5 41 5 H. H. NNP cord-011310-fm578rm5 41 6 pylori pylori NN cord-011310-fm578rm5 41 7 to to IN cord-011310-fm578rm5 41 8 clarithromycin clarithromycin NNP cord-011310-fm578rm5 41 9 correlates correlate VBZ cord-011310-fm578rm5 41 10 to to IN cord-011310-fm578rm5 41 11 the the DT cord-011310-fm578rm5 41 12 overall overall JJ cord-011310-fm578rm5 41 13 use use NN cord-011310-fm578rm5 41 14 of of IN cord-011310-fm578rm5 41 15 this this DT cord-011310-fm578rm5 41 16 antibiotic antibiotic NN cord-011310-fm578rm5 41 17 in in IN cord-011310-fm578rm5 41 18 a a DT cord-011310-fm578rm5 41 19 particular particular JJ cord-011310-fm578rm5 41 20 population population NN cord-011310-fm578rm5 41 21 , , , cord-011310-fm578rm5 41 22 the the DT cord-011310-fm578rm5 41 23 choice choice NN cord-011310-fm578rm5 41 24 of of IN cord-011310-fm578rm5 41 25 treatment treatment NN cord-011310-fm578rm5 41 26 solely solely RB cord-011310-fm578rm5 41 27 depends depend VBZ cord-011310-fm578rm5 41 28 on on IN cord-011310-fm578rm5 41 29 H. h. NN cord-011310-fm578rm5 41 30 pylori pylori NN cord-011310-fm578rm5 41 31 resistance resistance NN cord-011310-fm578rm5 41 32 . . . cord-011310-fm578rm5 42 1 Furthermore furthermore RB cord-011310-fm578rm5 42 2 , , , cord-011310-fm578rm5 42 3 no no DT cord-011310-fm578rm5 42 4 differences difference NNS cord-011310-fm578rm5 42 5 in in IN cord-011310-fm578rm5 42 6 the the DT cord-011310-fm578rm5 42 7 eradication eradication NN cord-011310-fm578rm5 42 8 regimen regimen NN cord-011310-fm578rm5 42 9 are be VBP cord-011310-fm578rm5 42 10 currently currently RB cord-011310-fm578rm5 42 11 recommended recommend VBN cord-011310-fm578rm5 42 12 , , , cord-011310-fm578rm5 42 13 depending depend VBG cord-011310-fm578rm5 42 14 on on IN cord-011310-fm578rm5 42 15 whether whether IN cord-011310-fm578rm5 42 16 the the DT cord-011310-fm578rm5 42 17 treatment treatment NN cord-011310-fm578rm5 42 18 is be VBZ cord-011310-fm578rm5 42 19 given give VBN cord-011310-fm578rm5 42 20 for for IN cord-011310-fm578rm5 42 21 a a DT cord-011310-fm578rm5 42 22 clinically clinically RB cord-011310-fm578rm5 42 23 evident evident JJ cord-011310-fm578rm5 42 24 disease disease NN cord-011310-fm578rm5 42 25 , , , cord-011310-fm578rm5 42 26 e.g. e.g. RB cord-011310-fm578rm5 42 27 for for IN cord-011310-fm578rm5 42 28 complicated complicated JJ cord-011310-fm578rm5 42 29 ulcer ulcer NN cord-011310-fm578rm5 42 30 disease disease NN cord-011310-fm578rm5 42 31 or or CC cord-011310-fm578rm5 42 32 MALT malt NN cord-011310-fm578rm5 42 33 lymphoma lymphoma NN cord-011310-fm578rm5 42 34 from from IN cord-011310-fm578rm5 42 35 prevention prevention NN cord-011310-fm578rm5 42 36 strategies strategy NNS cord-011310-fm578rm5 42 37 in in IN cord-011310-fm578rm5 42 38 population population NN cord-011310-fm578rm5 42 39 - - HYPH cord-011310-fm578rm5 42 40 based base VBN cord-011310-fm578rm5 42 41 settings setting NNS cord-011310-fm578rm5 42 42 . . . cord-011310-fm578rm5 43 1 The the DT cord-011310-fm578rm5 43 2 author author NN cord-011310-fm578rm5 43 3 viewpoint viewpoint NN cord-011310-fm578rm5 43 4 is be VBZ cord-011310-fm578rm5 43 5 that that IN cord-011310-fm578rm5 43 6 negative negative JJ cord-011310-fm578rm5 43 7 effects effect NNS cord-011310-fm578rm5 43 8 upon upon IN cord-011310-fm578rm5 43 9 the the DT cord-011310-fm578rm5 43 10 gut gut NN cord-011310-fm578rm5 43 11 microbiome microbiome NN cord-011310-fm578rm5 43 12 would would MD cord-011310-fm578rm5 43 13 not not RB cord-011310-fm578rm5 43 14 be be VB cord-011310-fm578rm5 43 15 a a DT cord-011310-fm578rm5 43 16 significant significant JJ cord-011310-fm578rm5 43 17 concern concern NN cord-011310-fm578rm5 43 18 in in IN cord-011310-fm578rm5 43 19 the the DT cord-011310-fm578rm5 43 20 case case NN cord-011310-fm578rm5 43 21 of of IN cord-011310-fm578rm5 43 22 treating treat VBG cord-011310-fm578rm5 43 23 patients patient NNS cord-011310-fm578rm5 43 24 with with IN cord-011310-fm578rm5 43 25 a a DT cord-011310-fm578rm5 43 26 clinically clinically RB cord-011310-fm578rm5 43 27 significant significant JJ cord-011310-fm578rm5 43 28 disease disease NN cord-011310-fm578rm5 43 29 , , , cord-011310-fm578rm5 43 30 yet yet CC cord-011310-fm578rm5 43 31 should should MD cord-011310-fm578rm5 43 32 be be VB cord-011310-fm578rm5 43 33 considered consider VBN cord-011310-fm578rm5 43 34 in in IN cord-011310-fm578rm5 43 35 preventive preventive JJ cord-011310-fm578rm5 43 36 interventions intervention NNS cord-011310-fm578rm5 43 37 . . . cord-011310-fm578rm5 44 1 The the DT cord-011310-fm578rm5 44 2 European European NNP cord-011310-fm578rm5 44 3 Maastricht Maastricht NNP cord-011310-fm578rm5 44 4 V V NNP cord-011310-fm578rm5 44 5 / / SYM cord-011310-fm578rm5 44 6 Florence Florence NNP cord-011310-fm578rm5 44 7 consensus consensus NN cord-011310-fm578rm5 44 8 ( ( -LRB- cord-011310-fm578rm5 44 9 ML ML NNP cord-011310-fm578rm5 44 10 was be VBD cord-011310-fm578rm5 44 11 part part NN cord-011310-fm578rm5 44 12 of of IN cord-011310-fm578rm5 44 13 the the DT cord-011310-fm578rm5 44 14 working work VBG cord-011310-fm578rm5 44 15 group group NN cord-011310-fm578rm5 44 16 ) ) -RRB- cord-011310-fm578rm5 44 17 recommended recommend VBD cord-011310-fm578rm5 44 18 the the DT cord-011310-fm578rm5 44 19 screenand screenand NN cord-011310-fm578rm5 44 20 - - HYPH cord-011310-fm578rm5 44 21 treat treat VB cord-011310-fm578rm5 44 22 strategy strategy NN cord-011310-fm578rm5 44 23 in in IN cord-011310-fm578rm5 44 24 communities community NNS cord-011310-fm578rm5 44 25 at at IN cord-011310-fm578rm5 44 26 high high JJ cord-011310-fm578rm5 44 27 risk risk NN cord-011310-fm578rm5 44 28 of of IN cord-011310-fm578rm5 44 29 gastric gastric JJ cord-011310-fm578rm5 44 30 cancer cancer NN cord-011310-fm578rm5 44 31 and and CC cord-011310-fm578rm5 44 32 consideration consideration NN cord-011310-fm578rm5 44 33 of of IN cord-011310-fm578rm5 44 34 this this DT cord-011310-fm578rm5 44 35 approach approach NN cord-011310-fm578rm5 44 36 in in IN cord-011310-fm578rm5 44 37 communities community NNS cord-011310-fm578rm5 44 38 with with IN cord-011310-fm578rm5 44 39 intermediate intermediate JJ cord-011310-fm578rm5 44 40 to to IN cord-011310-fm578rm5 44 41 low low JJ cord-011310-fm578rm5 44 42 risk risk NN cord-011310-fm578rm5 44 43 of of IN cord-011310-fm578rm5 44 44 gastric gastric JJ cord-011310-fm578rm5 44 45 cancer cancer NN cord-011310-fm578rm5 44 46 [ [ -LRB- cord-011310-fm578rm5 44 47 11 11 CD cord-011310-fm578rm5 44 48 ] ] -RRB- cord-011310-fm578rm5 44 49 . . . cord-011310-fm578rm5 45 1 Kyoto Kyoto NNP cord-011310-fm578rm5 45 2 global global JJ cord-011310-fm578rm5 45 3 consensus consensus NN cord-011310-fm578rm5 45 4 has have VBZ cord-011310-fm578rm5 45 5 for for IN cord-011310-fm578rm5 45 6 the the DT cord-011310-fm578rm5 45 7 first first JJ cord-011310-fm578rm5 45 8 time time NN cord-011310-fm578rm5 45 9 categorized categorize VBN cord-011310-fm578rm5 45 10 H. h. NN cord-011310-fm578rm5 45 11 pylori pylori NN cord-011310-fm578rm5 45 12 gastritis gastritis NN cord-011310-fm578rm5 45 13 as as IN cord-011310-fm578rm5 45 14 an an DT cord-011310-fm578rm5 45 15 infectious infectious JJ cord-011310-fm578rm5 45 16 disease disease NN cord-011310-fm578rm5 45 17 , , , cord-011310-fm578rm5 45 18 irrespective irrespective RB cord-011310-fm578rm5 45 19 of of IN cord-011310-fm578rm5 45 20 symptoms symptom NNS cord-011310-fm578rm5 45 21 and and CC cord-011310-fm578rm5 45 22 complications complication NNS cord-011310-fm578rm5 45 23 [ [ -LRB- cord-011310-fm578rm5 45 24 17 17 CD cord-011310-fm578rm5 45 25 ] ] -RRB- cord-011310-fm578rm5 45 26 , , , cord-011310-fm578rm5 45 27 which which WDT cord-011310-fm578rm5 45 28 has have VBZ cord-011310-fm578rm5 45 29 been be VBN cord-011310-fm578rm5 45 30 reinforced reinforce VBN cord-011310-fm578rm5 45 31 by by IN cord-011310-fm578rm5 45 32 the the DT cord-011310-fm578rm5 45 33 Maastricht Maastricht NNP cord-011310-fm578rm5 45 34 V V NNP cord-011310-fm578rm5 45 35 [ [ -LRB- cord-011310-fm578rm5 45 36 11 11 CD cord-011310-fm578rm5 45 37 ] ] -RRB- cord-011310-fm578rm5 45 38 and and CC cord-011310-fm578rm5 45 39 Brazilian brazilian JJ cord-011310-fm578rm5 45 40 consensus consensus NN cord-011310-fm578rm5 45 41 [ [ -LRB- cord-011310-fm578rm5 45 42 18 18 CD cord-011310-fm578rm5 45 43 ] ] -RRB- cord-011310-fm578rm5 45 44 . . . cord-011310-fm578rm5 46 1 All all DT cord-011310-fm578rm5 46 2 H. H. NNP cord-011310-fm578rm5 46 3 pylori pylori NN cord-011310-fm578rm5 47 1 infected infected JJ cord-011310-fm578rm5 47 2 subjects subject NNS cord-011310-fm578rm5 47 3 are be VBP cord-011310-fm578rm5 47 4 recommended recommend VBN cord-011310-fm578rm5 47 5 to to TO cord-011310-fm578rm5 47 6 undergo undergo VB cord-011310-fm578rm5 47 7 eradication eradication NN cord-011310-fm578rm5 47 8 therapy therapy NN cord-011310-fm578rm5 47 9 according accord VBG cord-011310-fm578rm5 47 10 to to IN cord-011310-fm578rm5 47 11 the the DT cord-011310-fm578rm5 47 12 Kyoto Kyoto NNP cord-011310-fm578rm5 47 13 consensus consensus NN cord-011310-fm578rm5 47 14 unless unless IN cord-011310-fm578rm5 47 15 there there EX cord-011310-fm578rm5 47 16 are be VBP cord-011310-fm578rm5 47 17 competing compete VBG cord-011310-fm578rm5 47 18 considerations consideration NNS cord-011310-fm578rm5 47 19 , , , cord-011310-fm578rm5 47 20 such such JJ cord-011310-fm578rm5 47 21 as as IN cord-011310-fm578rm5 47 22 comorbidities comorbiditie NNS cord-011310-fm578rm5 47 23 , , , cord-011310-fm578rm5 47 24 re re NN cord-011310-fm578rm5 47 25 - - NN cord-011310-fm578rm5 47 26 infection infection NN cord-011310-fm578rm5 47 27 rates rate NNS cord-011310-fm578rm5 47 28 in in IN cord-011310-fm578rm5 47 29 their -PRON- PRP$ cord-011310-fm578rm5 47 30 communities community NNS cord-011310-fm578rm5 47 31 , , , cord-011310-fm578rm5 47 32 competing compete VBG cord-011310-fm578rm5 47 33 health health NN cord-011310-fm578rm5 47 34 priorities priority NNS cord-011310-fm578rm5 47 35 of of IN cord-011310-fm578rm5 47 36 society society NN cord-011310-fm578rm5 47 37 or or CC cord-011310-fm578rm5 47 38 financial financial JJ cord-011310-fm578rm5 47 39 issues issue NNS cord-011310-fm578rm5 47 40 [ [ -LRB- cord-011310-fm578rm5 47 41 17 17 CD cord-011310-fm578rm5 47 42 ] ] -RRB- cord-011310-fm578rm5 47 43 . . . cord-011310-fm578rm5 48 1 The the DT cord-011310-fm578rm5 48 2 recent recent JJ cord-011310-fm578rm5 48 3 guidelines guideline NNS cord-011310-fm578rm5 48 4 of of IN cord-011310-fm578rm5 48 5 ASEAN ASEAN NNP cord-011310-fm578rm5 48 6 ( ( -LRB- cord-011310-fm578rm5 48 7 Association Association NNP cord-011310-fm578rm5 48 8 Southeast Southeast NNP cord-011310-fm578rm5 48 9 Asian Asian NNP cord-011310-fm578rm5 48 10 Nations Nations NNPS cord-011310-fm578rm5 48 11 ) ) -RRB- cord-011310-fm578rm5 48 12 countries country NNS cord-011310-fm578rm5 48 13 support support VBP cord-011310-fm578rm5 48 14 eradication eradication NN cord-011310-fm578rm5 48 15 to to TO cord-011310-fm578rm5 48 16 prevent prevent VB cord-011310-fm578rm5 48 17 gastric gastric JJ cord-011310-fm578rm5 48 18 cancer cancer NN cord-011310-fm578rm5 48 19 by by IN cord-011310-fm578rm5 48 20 considering consider VBG cord-011310-fm578rm5 48 21 this this DT cord-011310-fm578rm5 48 22 strategy strategy NN cord-011310-fm578rm5 48 23 as as IN cord-011310-fm578rm5 48 24 costeffective costeffective JJ cord-011310-fm578rm5 48 25 , , , cord-011310-fm578rm5 48 26 depending depend VBG cord-011310-fm578rm5 48 27 on on IN cord-011310-fm578rm5 48 28 the the DT cord-011310-fm578rm5 48 29 disease disease NN cord-011310-fm578rm5 48 30 burden burden NN cord-011310-fm578rm5 48 31 in in IN cord-011310-fm578rm5 48 32 the the DT cord-011310-fm578rm5 48 33 relevant relevant JJ cord-011310-fm578rm5 48 34 community community NN cord-011310-fm578rm5 48 35 [ [ -LRB- cord-011310-fm578rm5 48 36 19 19 CD cord-011310-fm578rm5 48 37 ] ] -RRB- cord-011310-fm578rm5 48 38 . . . cord-011310-fm578rm5 49 1 A a DT cord-011310-fm578rm5 49 2 similar similar JJ cord-011310-fm578rm5 49 3 opinion opinion NN cord-011310-fm578rm5 49 4 was be VBD cord-011310-fm578rm5 49 5 formed form VBN cord-011310-fm578rm5 49 6 in in IN cord-011310-fm578rm5 49 7 the the DT cord-011310-fm578rm5 49 8 Second Second NNP cord-011310-fm578rm5 49 9 Asia Asia NNP cord-011310-fm578rm5 49 10 - - HYPH cord-011310-fm578rm5 49 11 Pacific Pacific NNP cord-011310-fm578rm5 49 12 Consensus Consensus NNP cord-011310-fm578rm5 49 13 Guidelines Guidelines NNPS cord-011310-fm578rm5 49 14 for for IN cord-011310-fm578rm5 49 15 H. H. NNP cord-011310-fm578rm5 49 16 pylori pylori NN cord-011310-fm578rm5 49 17 infection infection NN cord-011310-fm578rm5 49 18 a a DT cord-011310-fm578rm5 49 19 decade decade NN cord-011310-fm578rm5 49 20 ago ago RB cord-011310-fm578rm5 49 21 for for IN cord-011310-fm578rm5 49 22 communities community NNS cord-011310-fm578rm5 49 23 with with IN cord-011310-fm578rm5 49 24 high high JJ cord-011310-fm578rm5 49 25 incidence incidence NN cord-011310-fm578rm5 49 26 of of IN cord-011310-fm578rm5 49 27 gastric gastric JJ cord-011310-fm578rm5 49 28 cancer cancer NN cord-011310-fm578rm5 49 29 [ [ -LRB- cord-011310-fm578rm5 49 30 20 20 CD cord-011310-fm578rm5 49 31 ] ] -RRB- cord-011310-fm578rm5 49 32 . . . cord-011310-fm578rm5 50 1 At at IN cord-011310-fm578rm5 50 2 the the DT cord-011310-fm578rm5 50 3 same same JJ cord-011310-fm578rm5 50 4 time time NN cord-011310-fm578rm5 50 5 , , , cord-011310-fm578rm5 50 6 some some DT cord-011310-fm578rm5 50 7 of of IN cord-011310-fm578rm5 50 8 the the DT cord-011310-fm578rm5 50 9 guidelines guideline NNS cord-011310-fm578rm5 50 10 and and CC cord-011310-fm578rm5 50 11 expert expert NN cord-011310-fm578rm5 50 12 group group NN cord-011310-fm578rm5 50 13 recommendations recommendation NNS cord-011310-fm578rm5 50 14 are be VBP cord-011310-fm578rm5 50 15 less less RBR cord-011310-fm578rm5 50 16 enthusiastic enthusiastic JJ cord-011310-fm578rm5 50 17 regarding regard VBG cord-011310-fm578rm5 50 18 population population NN cord-011310-fm578rm5 50 19 - - HYPH cord-011310-fm578rm5 50 20 based base VBN cord-011310-fm578rm5 50 21 eradication eradication NN cord-011310-fm578rm5 50 22 . . . cord-011310-fm578rm5 51 1 The the DT cord-011310-fm578rm5 51 2 American American NNP cord-011310-fm578rm5 51 3 College College NNP cord-011310-fm578rm5 51 4 of of IN cord-011310-fm578rm5 51 5 Gastroenterology Gastroenterology NNP cord-011310-fm578rm5 51 6 does do VBZ cord-011310-fm578rm5 51 7 not not RB cord-011310-fm578rm5 51 8 recommend recommend VB cord-011310-fm578rm5 51 9 active active JJ cord-011310-fm578rm5 51 10 search search NN cord-011310-fm578rm5 51 11 of of IN cord-011310-fm578rm5 51 12 H. h. NN cord-011310-fm578rm5 51 13 pylori pylori NN cord-011310-fm578rm5 51 14 in in IN cord-011310-fm578rm5 51 15 an an DT cord-011310-fm578rm5 51 16 asymptomatic asymptomatic JJ cord-011310-fm578rm5 51 17 population population NN cord-011310-fm578rm5 51 18 [ [ -LRB- cord-011310-fm578rm5 51 19 21 21 CD cord-011310-fm578rm5 51 20 ] ] -RRB- cord-011310-fm578rm5 51 21 . . . cord-011310-fm578rm5 52 1 An an DT cord-011310-fm578rm5 52 2 expert expert NN cord-011310-fm578rm5 52 3 group group NN cord-011310-fm578rm5 52 4 hosted host VBN cord-011310-fm578rm5 52 5 by by IN cord-011310-fm578rm5 52 6 IARC IARC NNP cord-011310-fm578rm5 52 7 has have VBZ cord-011310-fm578rm5 52 8 suggested suggest VBN cord-011310-fm578rm5 52 9 the the DT cord-011310-fm578rm5 52 10 need need NN cord-011310-fm578rm5 52 11 for for IN cord-011310-fm578rm5 52 12 interventional interventional JJ cord-011310-fm578rm5 52 13 strategies strategy NNS cord-011310-fm578rm5 52 14 to to TO cord-011310-fm578rm5 52 15 decrease decrease VB cord-011310-fm578rm5 52 16 the the DT cord-011310-fm578rm5 52 17 burden burden NN cord-011310-fm578rm5 52 18 of of IN cord-011310-fm578rm5 52 19 gastric gastric JJ cord-011310-fm578rm5 52 20 cancer cancer NN cord-011310-fm578rm5 52 21 [ [ -LRB- cord-011310-fm578rm5 52 22 1 1 CD cord-011310-fm578rm5 52 23 , , , cord-011310-fm578rm5 52 24 22 22 CD cord-011310-fm578rm5 52 25 ] ] -RRB- cord-011310-fm578rm5 52 26 ; ; : cord-011310-fm578rm5 52 27 however however RB cord-011310-fm578rm5 52 28 , , , cord-011310-fm578rm5 52 29 experts expert NNS cord-011310-fm578rm5 52 30 recommended recommend VBD cord-011310-fm578rm5 52 31 that that IN cord-011310-fm578rm5 52 32 this this DT cord-011310-fm578rm5 52 33 be be VB cord-011310-fm578rm5 52 34 done do VBN cord-011310-fm578rm5 52 35 by by IN cord-011310-fm578rm5 52 36 the the DT cord-011310-fm578rm5 52 37 means mean NNS cord-011310-fm578rm5 52 38 of of IN cord-011310-fm578rm5 52 39 well well RB cord-011310-fm578rm5 52 40 - - HYPH cord-011310-fm578rm5 52 41 designed design VBN cord-011310-fm578rm5 52 42 clinical clinical JJ cord-011310-fm578rm5 52 43 studies study NNS cord-011310-fm578rm5 52 44 evaluating evaluate VBG cord-011310-fm578rm5 52 45 the the DT cord-011310-fm578rm5 52 46 feasibility feasibility NN cord-011310-fm578rm5 52 47 , , , cord-011310-fm578rm5 52 48 acceptance acceptance NN cord-011310-fm578rm5 52 49 , , , cord-011310-fm578rm5 52 50 costs cost NNS cord-011310-fm578rm5 52 51 , , , cord-011310-fm578rm5 52 52 effectiveness effectiveness NN cord-011310-fm578rm5 52 53 and and CC cord-011310-fm578rm5 52 54 adverse adverse JJ cord-011310-fm578rm5 52 55 consequences consequence NNS cord-011310-fm578rm5 52 56 . . . cord-011310-fm578rm5 53 1 A a DT cord-011310-fm578rm5 53 2 European european JJ cord-011310-fm578rm5 53 3 expert expert NN cord-011310-fm578rm5 53 4 group group NN cord-011310-fm578rm5 53 5 ( ( -LRB- cord-011310-fm578rm5 53 6 ML ML NNP cord-011310-fm578rm5 53 7 was be VBD cord-011310-fm578rm5 53 8 part part NN cord-011310-fm578rm5 53 9 of of IN cord-011310-fm578rm5 53 10 the the DT cord-011310-fm578rm5 53 11 working work VBG cord-011310-fm578rm5 53 12 group group NN cord-011310-fm578rm5 53 13 ) ) -RRB- cord-011310-fm578rm5 53 14 within within IN cord-011310-fm578rm5 53 15 the the DT cord-011310-fm578rm5 53 16 EU EU NNP cord-011310-fm578rm5 53 17 Joint Joint NNP cord-011310-fm578rm5 53 18 Action Action NNP cord-011310-fm578rm5 53 19 in in IN cord-011310-fm578rm5 53 20 Cancer Cancer NNP cord-011310-fm578rm5 53 21 Control Control NNP cord-011310-fm578rm5 53 22 ( ( -LRB- cord-011310-fm578rm5 53 23 CanCon CanCon NNP cord-011310-fm578rm5 53 24 ) ) -RRB- cord-011310-fm578rm5 53 25 has have VBZ cord-011310-fm578rm5 53 26 been be VBN cord-011310-fm578rm5 53 27 even even RB cord-011310-fm578rm5 53 28 more more RBR cord-011310-fm578rm5 53 29 critical critical JJ cord-011310-fm578rm5 53 30 - - : cord-011310-fm578rm5 53 31 they -PRON- PRP cord-011310-fm578rm5 53 32 concluded conclude VBD cord-011310-fm578rm5 53 33 that that IN cord-011310-fm578rm5 53 34 , , , cord-011310-fm578rm5 53 35 as as IN cord-011310-fm578rm5 53 36 of of IN cord-011310-fm578rm5 53 37 today today NN cord-011310-fm578rm5 53 38 , , , cord-011310-fm578rm5 53 39 there there EX cord-011310-fm578rm5 53 40 is be VBZ cord-011310-fm578rm5 53 41 no no DT cord-011310-fm578rm5 53 42 screening screening NN cord-011310-fm578rm5 53 43 method method NN cord-011310-fm578rm5 53 44 that that WDT cord-011310-fm578rm5 53 45 can can MD cord-011310-fm578rm5 53 46 be be VB cord-011310-fm578rm5 53 47 readily readily RB cord-011310-fm578rm5 53 48 recommended recommend VBN cord-011310-fm578rm5 53 49 for for IN cord-011310-fm578rm5 53 50 implementation implementation NN cord-011310-fm578rm5 53 51 in in IN cord-011310-fm578rm5 53 52 the the DT cord-011310-fm578rm5 53 53 EU EU NNP cord-011310-fm578rm5 53 54 Member Member NNP cord-011310-fm578rm5 53 55 States States NNP cord-011310-fm578rm5 53 56 , , , cord-011310-fm578rm5 53 57 although although IN cord-011310-fm578rm5 53 58 there there EX cord-011310-fm578rm5 53 59 seems seem VBZ cord-011310-fm578rm5 53 60 to to TO cord-011310-fm578rm5 53 61 be be VB cord-011310-fm578rm5 53 62 a a DT cord-011310-fm578rm5 53 63 need need NN cord-011310-fm578rm5 53 64 for for IN cord-011310-fm578rm5 53 65 one one CD cord-011310-fm578rm5 53 66 [ [ -LRB- cord-011310-fm578rm5 53 67 12 12 CD cord-011310-fm578rm5 53 68 ] ] -RRB- cord-011310-fm578rm5 53 69 . . . cord-011310-fm578rm5 54 1 This this DT cord-011310-fm578rm5 54 2 also also RB cord-011310-fm578rm5 54 3 included include VBD cord-011310-fm578rm5 54 4 the the DT cord-011310-fm578rm5 54 5 screen screen NN cord-011310-fm578rm5 54 6 - - HYPH cord-011310-fm578rm5 54 7 and and CC cord-011310-fm578rm5 54 8 - - HYPH cord-011310-fm578rm5 54 9 treat treat VB cord-011310-fm578rm5 54 10 strategy strategy NN cord-011310-fm578rm5 54 11 for for IN cord-011310-fm578rm5 54 12 H. h. NN cord-011310-fm578rm5 54 13 pylori pylori NN cord-011310-fm578rm5 54 14 . . . cord-011310-fm578rm5 55 1 There there EX cord-011310-fm578rm5 55 2 is be VBZ cord-011310-fm578rm5 55 3 common common JJ cord-011310-fm578rm5 55 4 agreement agreement NN cord-011310-fm578rm5 55 5 [ [ -LRB- cord-011310-fm578rm5 55 6 8 8 CD cord-011310-fm578rm5 55 7 , , , cord-011310-fm578rm5 55 8 11 11 CD cord-011310-fm578rm5 55 9 , , , cord-011310-fm578rm5 55 10 17 17 CD cord-011310-fm578rm5 55 11 ] ] -RRB- cord-011310-fm578rm5 55 12 that that IN cord-011310-fm578rm5 55 13 the the DT cord-011310-fm578rm5 55 14 optimal optimal JJ cord-011310-fm578rm5 55 15 timing timing NN cord-011310-fm578rm5 55 16 for for IN cord-011310-fm578rm5 55 17 eradicating eradicate VBG cord-011310-fm578rm5 55 18 H. H. NNP cord-011310-fm578rm5 55 19 pylori pylori NN cord-011310-fm578rm5 55 20 must must MD cord-011310-fm578rm5 55 21 come come VB cord-011310-fm578rm5 55 22 before before IN cord-011310-fm578rm5 55 23 the the DT cord-011310-fm578rm5 55 24 development development NN cord-011310-fm578rm5 55 25 of of IN cord-011310-fm578rm5 55 26 precancerous precancerous JJ cord-011310-fm578rm5 55 27 lesions lesion NNS cord-011310-fm578rm5 55 28 , , , cord-011310-fm578rm5 55 29 since since IN cord-011310-fm578rm5 55 30 a a DT cord-011310-fm578rm5 55 31 proportion proportion NN cord-011310-fm578rm5 55 32 of of IN cord-011310-fm578rm5 55 33 the the DT cord-011310-fm578rm5 55 34 subjects subject NNS cord-011310-fm578rm5 55 35 could could MD cord-011310-fm578rm5 55 36 be be VB cord-011310-fm578rm5 55 37 progressing progress VBG cord-011310-fm578rm5 55 38 to to IN cord-011310-fm578rm5 55 39 gastric gastric JJ cord-011310-fm578rm5 55 40 cancer cancer NN cord-011310-fm578rm5 55 41 if if IN cord-011310-fm578rm5 55 42 eradicated eradicate VBN cord-011310-fm578rm5 55 43 at at IN cord-011310-fm578rm5 55 44 the the DT cord-011310-fm578rm5 55 45 stage stage NN cord-011310-fm578rm5 55 46 that that IN cord-011310-fm578rm5 55 47 precancerous precancerous JJ cord-011310-fm578rm5 55 48 lesions lesion NNS cord-011310-fm578rm5 55 49 ( ( -LRB- cord-011310-fm578rm5 55 50 atrophy atrophy NN cord-011310-fm578rm5 55 51 , , , cord-011310-fm578rm5 55 52 intestinal intestinal JJ cord-011310-fm578rm5 55 53 metaplasia metaplasia NN cord-011310-fm578rm5 55 54 , , , cord-011310-fm578rm5 55 55 dysplasia dysplasia NN cord-011310-fm578rm5 55 56 ) ) -RRB- cord-011310-fm578rm5 55 57 become become VBP cord-011310-fm578rm5 55 58 evident evident JJ cord-011310-fm578rm5 55 59 . . . cord-011310-fm578rm5 56 1 In in IN cord-011310-fm578rm5 56 2 Japan Japan NNP cord-011310-fm578rm5 56 3 , , , cord-011310-fm578rm5 56 4 currently currently RB cord-011310-fm578rm5 56 5 eradication eradication NN cord-011310-fm578rm5 56 6 therapy therapy NN cord-011310-fm578rm5 56 7 is be VBZ cord-011310-fm578rm5 56 8 reimbursed reimburse VBN cord-011310-fm578rm5 56 9 for for IN cord-011310-fm578rm5 56 10 all all PDT cord-011310-fm578rm5 56 11 the the DT cord-011310-fm578rm5 56 12 individuals individual NNS cord-011310-fm578rm5 56 13 with with IN cord-011310-fm578rm5 56 14 H. H. NNP cord-011310-fm578rm5 56 15 pylori pylori NN cord-011310-fm578rm5 56 16 infection infection NN cord-011310-fm578rm5 56 17 and and CC cord-011310-fm578rm5 56 18 active active JJ cord-011310-fm578rm5 56 19 gastritis gastritis NN cord-011310-fm578rm5 56 20 ( ( -LRB- cord-011310-fm578rm5 56 21 in in IN cord-011310-fm578rm5 56 22 addition addition NN cord-011310-fm578rm5 56 23 to to IN cord-011310-fm578rm5 56 24 the the DT cord-011310-fm578rm5 56 25 ongoing ongoing JJ cord-011310-fm578rm5 56 26 screening screening NN cord-011310-fm578rm5 56 27 activities activity NNS cord-011310-fm578rm5 56 28 for for IN cord-011310-fm578rm5 56 29 1 1 CD cord-011310-fm578rm5 56 30 3 3 CD cord-011310-fm578rm5 56 31 gastric gastric JJ cord-011310-fm578rm5 56 32 cancer cancer NN cord-011310-fm578rm5 56 33 ) ) -RRB- cord-011310-fm578rm5 56 34 , , , cord-011310-fm578rm5 56 35 which which WDT cord-011310-fm578rm5 56 36 means mean VBZ cord-011310-fm578rm5 56 37 that that IN cord-011310-fm578rm5 56 38 endoscopy endoscopy NN cord-011310-fm578rm5 56 39 is be VBZ cord-011310-fm578rm5 56 40 required require VBN cord-011310-fm578rm5 56 41 to to TO cord-011310-fm578rm5 56 42 confirm confirm VB cord-011310-fm578rm5 56 43 the the DT cord-011310-fm578rm5 56 44 condition condition NN cord-011310-fm578rm5 56 45 . . . cord-011310-fm578rm5 57 1 Thereafter thereafter RB cord-011310-fm578rm5 57 2 , , , cord-011310-fm578rm5 57 3 significant significant JJ cord-011310-fm578rm5 57 4 increase increase NN cord-011310-fm578rm5 57 5 in in IN cord-011310-fm578rm5 57 6 eradication eradication NN cord-011310-fm578rm5 57 7 therapies therapy NNS cord-011310-fm578rm5 57 8 has have VBZ cord-011310-fm578rm5 57 9 occurred occur VBN cord-011310-fm578rm5 57 10 [ [ -LRB- cord-011310-fm578rm5 57 11 23 23 CD cord-011310-fm578rm5 57 12 ] ] -RRB- cord-011310-fm578rm5 57 13 , , , cord-011310-fm578rm5 57 14 yet yet CC cord-011310-fm578rm5 57 15 this this DT cord-011310-fm578rm5 57 16 can can MD cord-011310-fm578rm5 57 17 not not RB cord-011310-fm578rm5 57 18 be be VB cord-011310-fm578rm5 57 19 considered consider VBN cord-011310-fm578rm5 57 20 an an DT cord-011310-fm578rm5 57 21 organized organized JJ cord-011310-fm578rm5 57 22 screening screening NN cord-011310-fm578rm5 57 23 strategy strategy NN cord-011310-fm578rm5 57 24 . . . cord-011310-fm578rm5 58 1 In in IN cord-011310-fm578rm5 58 2 Korea Korea NNP cord-011310-fm578rm5 58 3 , , , cord-011310-fm578rm5 58 4 a a DT cord-011310-fm578rm5 58 5 high high JJ cord-011310-fm578rm5 58 6 gastric gastric JJ cord-011310-fm578rm5 58 7 cancer cancer NN cord-011310-fm578rm5 58 8 incidence incidence NN cord-011310-fm578rm5 58 9 country country NN cord-011310-fm578rm5 58 10 with with IN cord-011310-fm578rm5 58 11 a a DT cord-011310-fm578rm5 58 12 gastric gastric JJ cord-011310-fm578rm5 58 13 cancer cancer NN cord-011310-fm578rm5 58 14 screening screening NN cord-011310-fm578rm5 58 15 program program NN cord-011310-fm578rm5 58 16 [ [ -LRB- cord-011310-fm578rm5 58 17 24 24 CD cord-011310-fm578rm5 58 18 ] ] -RRB- cord-011310-fm578rm5 58 19 , , , cord-011310-fm578rm5 58 20 H. H. NNP cord-011310-fm578rm5 58 21 pylori pylori NN cord-011310-fm578rm5 58 22 management management NN cord-011310-fm578rm5 58 23 guidelines guideline NNS cord-011310-fm578rm5 58 24 do do VBP cord-011310-fm578rm5 58 25 not not RB cord-011310-fm578rm5 58 26 address address VB cord-011310-fm578rm5 58 27 the the DT cord-011310-fm578rm5 58 28 search search NN cord-011310-fm578rm5 58 29 for for IN cord-011310-fm578rm5 58 30 the the DT cord-011310-fm578rm5 58 31 presence presence NN cord-011310-fm578rm5 58 32 of of IN cord-011310-fm578rm5 58 33 the the DT cord-011310-fm578rm5 58 34 bacteria bacteria NNS cord-011310-fm578rm5 58 35 in in IN cord-011310-fm578rm5 58 36 general general JJ cord-011310-fm578rm5 58 37 population population NN cord-011310-fm578rm5 58 38 [ [ -LRB- cord-011310-fm578rm5 58 39 25 25 CD cord-011310-fm578rm5 58 40 ] ] -RRB- cord-011310-fm578rm5 58 41 . . . cord-011310-fm578rm5 59 1 The the DT cord-011310-fm578rm5 59 2 country country NN cord-011310-fm578rm5 59 3 probably probably RB cord-011310-fm578rm5 59 4 closest close JJS cord-011310-fm578rm5 59 5 to to IN cord-011310-fm578rm5 59 6 the the DT cord-011310-fm578rm5 59 7 real real JJ cord-011310-fm578rm5 59 8 implementation implementation NN cord-011310-fm578rm5 59 9 of of IN cord-011310-fm578rm5 59 10 screen screen NN cord-011310-fm578rm5 59 11 - - HYPH cord-011310-fm578rm5 59 12 and and CC cord-011310-fm578rm5 59 13 - - HYPH cord-011310-fm578rm5 59 14 treat treat VB cord-011310-fm578rm5 59 15 strategy strategy NN cord-011310-fm578rm5 59 16 in in IN cord-011310-fm578rm5 59 17 an an DT cord-011310-fm578rm5 59 18 organized organized JJ cord-011310-fm578rm5 59 19 way way NN cord-011310-fm578rm5 59 20 is be VBZ cord-011310-fm578rm5 59 21 Slovenia Slovenia NNP cord-011310-fm578rm5 59 22 , , , cord-011310-fm578rm5 59 23 where where WRB cord-011310-fm578rm5 59 24 the the DT cord-011310-fm578rm5 59 25 professional professional JJ cord-011310-fm578rm5 59 26 society society NN cord-011310-fm578rm5 59 27 has have VBZ cord-011310-fm578rm5 59 28 issued issue VBN cord-011310-fm578rm5 59 29 guidelines guideline NNS cord-011310-fm578rm5 59 30 for for IN cord-011310-fm578rm5 59 31 such such PDT cord-011310-fm578rm5 59 32 a a DT cord-011310-fm578rm5 59 33 strategy strategy NN cord-011310-fm578rm5 59 34 [ [ -LRB- cord-011310-fm578rm5 59 35 26 26 CD cord-011310-fm578rm5 59 36 ] ] -RRB- cord-011310-fm578rm5 59 37 ; ; : cord-011310-fm578rm5 59 38 it -PRON- PRP cord-011310-fm578rm5 59 39 must must MD cord-011310-fm578rm5 59 40 be be VB cord-011310-fm578rm5 59 41 mentioned mention VBN cord-011310-fm578rm5 59 42 that that IN cord-011310-fm578rm5 59 43 this this DT cord-011310-fm578rm5 59 44 country country NN cord-011310-fm578rm5 59 45 has have VBZ cord-011310-fm578rm5 59 46 considerable considerable JJ cord-011310-fm578rm5 59 47 experience experience NN cord-011310-fm578rm5 59 48 in in IN cord-011310-fm578rm5 59 49 implementing implement VBG cord-011310-fm578rm5 59 50 other other JJ cord-011310-fm578rm5 59 51 types type NNS cord-011310-fm578rm5 59 52 of of IN cord-011310-fm578rm5 59 53 cancer cancer NN cord-011310-fm578rm5 59 54 screening screening NN cord-011310-fm578rm5 59 55 in in IN cord-011310-fm578rm5 59 56 an an DT cord-011310-fm578rm5 59 57 organized organized JJ cord-011310-fm578rm5 59 58 manner manner NN cord-011310-fm578rm5 59 59 , , , cord-011310-fm578rm5 59 60 including include VBG cord-011310-fm578rm5 59 61 screening screening NN cord-011310-fm578rm5 59 62 for for IN cord-011310-fm578rm5 59 63 colorectal colorectal JJ cord-011310-fm578rm5 59 64 cancer cancer NN cord-011310-fm578rm5 59 65 . . . cord-011310-fm578rm5 60 1 Fourteen fourteen CD cord-011310-fm578rm5 60 2 - - HYPH cord-011310-fm578rm5 60 3 day day NN cord-011310-fm578rm5 60 4 duration duration NN cord-011310-fm578rm5 60 5 of of IN cord-011310-fm578rm5 60 6 eradication eradication NN cord-011310-fm578rm5 60 7 therapies therapy NNS cord-011310-fm578rm5 60 8 , , , cord-011310-fm578rm5 60 9 including include VBG cord-011310-fm578rm5 60 10 for for IN cord-011310-fm578rm5 60 11 bismuth bismuth NN cord-011310-fm578rm5 60 12 - - HYPH cord-011310-fm578rm5 60 13 containing contain VBG cord-011310-fm578rm5 60 14 therapies therapy NNS cord-011310-fm578rm5 60 15 , , , cord-011310-fm578rm5 60 16 is be VBZ cord-011310-fm578rm5 60 17 currently currently RB cord-011310-fm578rm5 60 18 recommended recommend VBN cord-011310-fm578rm5 60 19 by by IN cord-011310-fm578rm5 60 20 Maastricht Maastricht NNP cord-011310-fm578rm5 60 21 V V NNP cord-011310-fm578rm5 60 22 , , , cord-011310-fm578rm5 60 23 unless unless IN cord-011310-fm578rm5 60 24 shorter short JJR cord-011310-fm578rm5 60 25 duration duration NN cord-011310-fm578rm5 60 26 therapies therapy NNS cord-011310-fm578rm5 60 27 ( ( -LRB- cord-011310-fm578rm5 60 28 10 10 CD cord-011310-fm578rm5 60 29 days day NNS cord-011310-fm578rm5 60 30 ) ) -RRB- cord-011310-fm578rm5 60 31 are be VBP cord-011310-fm578rm5 60 32 proven prove VBN cord-011310-fm578rm5 60 33 effective effective JJ cord-011310-fm578rm5 60 34 locally locally RB cord-011310-fm578rm5 60 35 [ [ -LRB- cord-011310-fm578rm5 60 36 11 11 CD cord-011310-fm578rm5 60 37 ] ] -RRB- cord-011310-fm578rm5 60 38 . . . cord-011310-fm578rm5 61 1 Similarly similarly RB cord-011310-fm578rm5 61 2 , , , cord-011310-fm578rm5 61 3 the the DT cord-011310-fm578rm5 61 4 Toronto Toronto NNP cord-011310-fm578rm5 61 5 consensus consensus NN cord-011310-fm578rm5 61 6 recommends recommend VBZ cord-011310-fm578rm5 61 7 a a DT cord-011310-fm578rm5 61 8 14-day 14-day CD cord-011310-fm578rm5 61 9 treatment treatment NN cord-011310-fm578rm5 61 10 [ [ -LRB- cord-011310-fm578rm5 61 11 27 27 CD cord-011310-fm578rm5 61 12 ] ] -RRB- cord-011310-fm578rm5 61 13 . . . cord-011310-fm578rm5 62 1 It -PRON- PRP cord-011310-fm578rm5 62 2 is be VBZ cord-011310-fm578rm5 62 3 noteworthy noteworthy JJ cord-011310-fm578rm5 62 4 that that IN cord-011310-fm578rm5 62 5 the the DT cord-011310-fm578rm5 62 6 recommended recommend VBN cord-011310-fm578rm5 62 7 duration duration NN cord-011310-fm578rm5 62 8 of of IN cord-011310-fm578rm5 62 9 treatment treatment NN cord-011310-fm578rm5 62 10 has have VBZ cord-011310-fm578rm5 62 11 extended extend VBN cord-011310-fm578rm5 62 12 with with IN cord-011310-fm578rm5 62 13 the the DT cord-011310-fm578rm5 62 14 time time NN cord-011310-fm578rm5 62 15 to to TO cord-011310-fm578rm5 62 16 achieve achieve VB cord-011310-fm578rm5 62 17 higher high JJR cord-011310-fm578rm5 62 18 effectiveness effectiveness NN cord-011310-fm578rm5 62 19 of of IN cord-011310-fm578rm5 62 20 these these DT cord-011310-fm578rm5 62 21 therapies therapy NNS cord-011310-fm578rm5 62 22 . . . cord-011310-fm578rm5 63 1 In in IN cord-011310-fm578rm5 63 2 2005 2005 CD cord-011310-fm578rm5 63 3 , , , cord-011310-fm578rm5 63 4 the the DT cord-011310-fm578rm5 63 5 Maastricht Maastricht NNP cord-011310-fm578rm5 63 6 III III NNP cord-011310-fm578rm5 63 7 consensus consensus NN cord-011310-fm578rm5 63 8 considered consider VBN cord-011310-fm578rm5 63 9 7 7 CD cord-011310-fm578rm5 63 10 days day NNS cord-011310-fm578rm5 63 11 as as IN cord-011310-fm578rm5 63 12 a a DT cord-011310-fm578rm5 63 13 valid valid JJ cord-011310-fm578rm5 63 14 duration duration NN cord-011310-fm578rm5 63 15 for for IN cord-011310-fm578rm5 63 16 treatment treatment NN cord-011310-fm578rm5 63 17 [ [ -LRB- cord-011310-fm578rm5 63 18 28 28 CD cord-011310-fm578rm5 63 19 ] ] -RRB- cord-011310-fm578rm5 63 20 . . . cord-011310-fm578rm5 64 1 Maastricht Maastricht NNP cord-011310-fm578rm5 64 2 IV IV NNP cord-011310-fm578rm5 64 3 in in IN cord-011310-fm578rm5 64 4 2010 2010 CD cord-011310-fm578rm5 64 5 extended extended JJ cord-011310-fm578rm5 64 6 treatment treatment NN cord-011310-fm578rm5 64 7 to to IN cord-011310-fm578rm5 64 8 10 10 CD cord-011310-fm578rm5 64 9 - - SYM cord-011310-fm578rm5 64 10 14 14 CD cord-011310-fm578rm5 64 11 days day NNS cord-011310-fm578rm5 64 12 giving give VBG cord-011310-fm578rm5 64 13 a a DT cord-011310-fm578rm5 64 14 gain gain NN cord-011310-fm578rm5 64 15 of of IN cord-011310-fm578rm5 64 16 ~ ~ CD cord-011310-fm578rm5 64 17 5 5 CD cord-011310-fm578rm5 64 18 % % NN cord-011310-fm578rm5 64 19 in in IN cord-011310-fm578rm5 64 20 the the DT cord-011310-fm578rm5 64 21 success success NN cord-011310-fm578rm5 64 22 rates rate NNS cord-011310-fm578rm5 64 23 [ [ -LRB- cord-011310-fm578rm5 64 24 29 29 CD cord-011310-fm578rm5 64 25 ] ] -RRB- cord-011310-fm578rm5 64 26 . . . cord-011310-fm578rm5 65 1 The the DT cord-011310-fm578rm5 65 2 general general NN cord-011310-fm578rm5 65 3 WHO WHO NNP cord-011310-fm578rm5 65 4 principles principle VBZ cord-011310-fm578rm5 65 5 for for IN cord-011310-fm578rm5 65 6 screening screening NN cord-011310-fm578rm5 65 7 have have VBP cord-011310-fm578rm5 65 8 been be VBN cord-011310-fm578rm5 65 9 set set VBN cord-011310-fm578rm5 65 10 more more JJR cord-011310-fm578rm5 65 11 than than IN cord-011310-fm578rm5 65 12 half half PDT cord-011310-fm578rm5 65 13 a a DT cord-011310-fm578rm5 65 14 century century NN cord-011310-fm578rm5 65 15 ago ago RB cord-011310-fm578rm5 65 16 by by IN cord-011310-fm578rm5 65 17 Wilson Wilson NNP cord-011310-fm578rm5 65 18 and and CC cord-011310-fm578rm5 65 19 Jungner Jungner NNP cord-011310-fm578rm5 65 20 [ [ -LRB- cord-011310-fm578rm5 65 21 30 30 CD cord-011310-fm578rm5 65 22 ] ] -RRB- cord-011310-fm578rm5 65 23 , , , cord-011310-fm578rm5 65 24 and and CC cord-011310-fm578rm5 65 25 they -PRON- PRP cord-011310-fm578rm5 65 26 are be VBP cord-011310-fm578rm5 65 27 still still RB cord-011310-fm578rm5 65 28 used use VBN cord-011310-fm578rm5 65 29 as as IN cord-011310-fm578rm5 65 30 of of IN cord-011310-fm578rm5 65 31 today today NN cord-011310-fm578rm5 65 32 although although IN cord-011310-fm578rm5 65 33 updated update VBN cord-011310-fm578rm5 65 34 in in IN cord-011310-fm578rm5 65 35 the the DT cord-011310-fm578rm5 65 36 new new JJ cord-011310-fm578rm5 65 37 genomic genomic JJ cord-011310-fm578rm5 65 38 era era NN cord-011310-fm578rm5 65 39 [ [ -LRB- cord-011310-fm578rm5 65 40 31 31 CD cord-011310-fm578rm5 65 41 ] ] -RRB- cord-011310-fm578rm5 65 42 . . . cord-011310-fm578rm5 66 1 Furthermore furthermore RB cord-011310-fm578rm5 66 2 , , , cord-011310-fm578rm5 66 3 principles principle NNS cord-011310-fm578rm5 66 4 of of IN cord-011310-fm578rm5 66 5 good good JJ cord-011310-fm578rm5 66 6 screening screening NN cord-011310-fm578rm5 66 7 organization organization NN cord-011310-fm578rm5 66 8 and and CC cord-011310-fm578rm5 66 9 governance governance NN cord-011310-fm578rm5 66 10 have have VBP cord-011310-fm578rm5 66 11 been be VBN cord-011310-fm578rm5 66 12 consistently consistently RB cord-011310-fm578rm5 66 13 emphasized emphasize VBN cord-011310-fm578rm5 66 14 by by IN cord-011310-fm578rm5 66 15 the the DT cord-011310-fm578rm5 66 16 expert expert JJ cord-011310-fm578rm5 66 17 groups group NNS cord-011310-fm578rm5 66 18 [ [ -LRB- cord-011310-fm578rm5 66 19 12 12 CD cord-011310-fm578rm5 66 20 ] ] -RRB- cord-011310-fm578rm5 66 21 . . . cord-011310-fm578rm5 67 1 The the DT cord-011310-fm578rm5 67 2 above above JJ cord-011310-fm578rm5 67 3 principles principle NNS cord-011310-fm578rm5 67 4 include include VBP cord-011310-fm578rm5 67 5 implementation implementation NN cord-011310-fm578rm5 67 6 of of IN cord-011310-fm578rm5 67 7 the the DT cord-011310-fm578rm5 67 8 program program NN cord-011310-fm578rm5 67 9 only only RB cord-011310-fm578rm5 67 10 when when WRB cord-011310-fm578rm5 67 11 sufficient sufficient JJ cord-011310-fm578rm5 67 12 scientific scientific JJ cord-011310-fm578rm5 67 13 evidence evidence NN cord-011310-fm578rm5 67 14 ( ( -LRB- cord-011310-fm578rm5 67 15 with with IN cord-011310-fm578rm5 67 16 proven prove VBN cord-011310-fm578rm5 67 17 effects effect NNS cord-011310-fm578rm5 67 18 on on IN cord-011310-fm578rm5 67 19 the the DT cord-011310-fm578rm5 67 20 mortality mortality NN cord-011310-fm578rm5 67 21 as as IN cord-011310-fm578rm5 67 22 the the DT cord-011310-fm578rm5 67 23 end end NN cord-011310-fm578rm5 67 24 - - HYPH cord-011310-fm578rm5 67 25 point point NN cord-011310-fm578rm5 67 26 ) ) -RRB- cord-011310-fm578rm5 67 27 is be VBZ cord-011310-fm578rm5 67 28 available available JJ cord-011310-fm578rm5 67 29 and and CC cord-011310-fm578rm5 67 30 following follow VBG cord-011310-fm578rm5 67 31 thorough thorough JJ cord-011310-fm578rm5 67 32 cost cost NN cord-011310-fm578rm5 67 33 effectiveness effectiveness NN cord-011310-fm578rm5 67 34 analysis analysis NN cord-011310-fm578rm5 67 35 , , , cord-011310-fm578rm5 67 36 precise precise JJ cord-011310-fm578rm5 67 37 definition definition NN cord-011310-fm578rm5 67 38 of of IN cord-011310-fm578rm5 67 39 the the DT cord-011310-fm578rm5 67 40 target target NN cord-011310-fm578rm5 67 41 population population NN cord-011310-fm578rm5 67 42 as as RB cord-011310-fm578rm5 67 43 well well RB cord-011310-fm578rm5 67 44 as as IN cord-011310-fm578rm5 67 45 invitation invitation NN cord-011310-fm578rm5 67 46 strategy strategy NN cord-011310-fm578rm5 67 47 , , , cord-011310-fm578rm5 67 48 piloting pilot VBG cord-011310-fm578rm5 67 49 of of IN cord-011310-fm578rm5 67 50 a a DT cord-011310-fm578rm5 67 51 screening screening NN cord-011310-fm578rm5 67 52 system system NN cord-011310-fm578rm5 67 53 , , , cord-011310-fm578rm5 67 54 setting set VBG cord-011310-fm578rm5 67 55 up up RP cord-011310-fm578rm5 67 56 a a DT cord-011310-fm578rm5 67 57 robust robust JJ cord-011310-fm578rm5 67 58 quality quality NN cord-011310-fm578rm5 67 59 assurance assurance NN cord-011310-fm578rm5 67 60 system system NN cord-011310-fm578rm5 67 61 before before IN cord-011310-fm578rm5 67 62 the the DT cord-011310-fm578rm5 67 63 system system NN cord-011310-fm578rm5 67 64 is be VBZ cord-011310-fm578rm5 67 65 launched launch VBN cord-011310-fm578rm5 67 66 in in IN cord-011310-fm578rm5 67 67 full full JJ cord-011310-fm578rm5 67 68 operation operation NN cord-011310-fm578rm5 67 69 . . . cord-011310-fm578rm5 68 1 H. H. NNP cord-011310-fm578rm5 68 2 pylori pylori NN cord-011310-fm578rm5 68 3 infection infection NN cord-011310-fm578rm5 68 4 is be VBZ cord-011310-fm578rm5 68 5 highly highly RB cord-011310-fm578rm5 68 6 prevalent prevalent JJ cord-011310-fm578rm5 68 7 , , , cord-011310-fm578rm5 68 8 affecting affect VBG cord-011310-fm578rm5 68 9 about about IN cord-011310-fm578rm5 68 10 half half NN cord-011310-fm578rm5 68 11 of of IN cord-011310-fm578rm5 68 12 the the DT cord-011310-fm578rm5 68 13 global global JJ cord-011310-fm578rm5 68 14 population population NN cord-011310-fm578rm5 68 15 [ [ -LRB- cord-011310-fm578rm5 68 16 32 32 CD cord-011310-fm578rm5 68 17 ] ] -RRB- cord-011310-fm578rm5 68 18 ; ; : cord-011310-fm578rm5 68 19 the the DT cord-011310-fm578rm5 68 20 prevalence prevalence NN cord-011310-fm578rm5 68 21 of of IN cord-011310-fm578rm5 68 22 precancerous precancerous JJ cord-011310-fm578rm5 68 23 lesions lesion NNS cord-011310-fm578rm5 68 24 in in IN cord-011310-fm578rm5 68 25 the the DT cord-011310-fm578rm5 68 26 general general JJ cord-011310-fm578rm5 68 27 population population NN cord-011310-fm578rm5 68 28 is be VBZ cord-011310-fm578rm5 68 29 also also RB cord-011310-fm578rm5 68 30 considerable considerable JJ cord-011310-fm578rm5 68 31 [ [ -LRB- cord-011310-fm578rm5 68 32 33 33 CD cord-011310-fm578rm5 68 33 ] ] -RRB- cord-011310-fm578rm5 68 34 . . . cord-011310-fm578rm5 69 1 Therefore therefore RB cord-011310-fm578rm5 69 2 , , , cord-011310-fm578rm5 69 3 population population NN cord-011310-fm578rm5 69 4 - - HYPH cord-011310-fm578rm5 69 5 based base VBN cord-011310-fm578rm5 69 6 efforts effort NNS cord-011310-fm578rm5 69 7 such such JJ cord-011310-fm578rm5 69 8 as as IN cord-011310-fm578rm5 69 9 the the DT cord-011310-fm578rm5 69 10 screen screen NN cord-011310-fm578rm5 69 11 - - HYPH cord-011310-fm578rm5 69 12 and and CC cord-011310-fm578rm5 69 13 - - HYPH cord-011310-fm578rm5 69 14 treat treat VB cord-011310-fm578rm5 69 15 strategy strategy NN cord-011310-fm578rm5 69 16 should should MD cord-011310-fm578rm5 69 17 follow follow VB cord-011310-fm578rm5 69 18 the the DT cord-011310-fm578rm5 69 19 general general JJ cord-011310-fm578rm5 69 20 rules rule NNS cord-011310-fm578rm5 69 21 of of IN cord-011310-fm578rm5 69 22 screening screening NN cord-011310-fm578rm5 69 23 . . . cord-011310-fm578rm5 70 1 It -PRON- PRP cord-011310-fm578rm5 70 2 must must MD cord-011310-fm578rm5 70 3 be be VB cord-011310-fm578rm5 70 4 mentioned mention VBN cord-011310-fm578rm5 70 5 that that IN cord-011310-fm578rm5 70 6 the the DT cord-011310-fm578rm5 70 7 current current JJ cord-011310-fm578rm5 70 8 H. H. NNP cord-011310-fm578rm5 70 9 pylori pylori NN cord-011310-fm578rm5 70 10 management management NN cord-011310-fm578rm5 70 11 guidelines guideline NNS cord-011310-fm578rm5 70 12 so so RB cord-011310-fm578rm5 70 13 far far RB cord-011310-fm578rm5 70 14 are be VBP cord-011310-fm578rm5 70 15 lacking lack VBG cord-011310-fm578rm5 70 16 this this DT cord-011310-fm578rm5 70 17 approach approach NN cord-011310-fm578rm5 70 18 . . . cord-011310-fm578rm5 71 1 Adverse adverse JJ cord-011310-fm578rm5 71 2 events event NNS cord-011310-fm578rm5 71 3 related relate VBN cord-011310-fm578rm5 71 4 to to IN cord-011310-fm578rm5 71 5 H. h. NN cord-011310-fm578rm5 71 6 pylori pylori NN cord-011310-fm578rm5 71 7 eradication eradication NN cord-011310-fm578rm5 71 8 therapy therapy NN cord-011310-fm578rm5 71 9 are be VBP cord-011310-fm578rm5 71 10 common common JJ cord-011310-fm578rm5 71 11 , , , cord-011310-fm578rm5 71 12 but but CC cord-011310-fm578rm5 71 13 usually usually RB cord-011310-fm578rm5 71 14 they -PRON- PRP cord-011310-fm578rm5 71 15 are be VBP cord-011310-fm578rm5 71 16 mild mild JJ cord-011310-fm578rm5 71 17 and and CC cord-011310-fm578rm5 71 18 of of IN cord-011310-fm578rm5 71 19 short short JJ cord-011310-fm578rm5 71 20 - - HYPH cord-011310-fm578rm5 71 21 term term NN cord-011310-fm578rm5 71 22 duration duration NN cord-011310-fm578rm5 71 23 ; ; : cord-011310-fm578rm5 71 24 the the DT cord-011310-fm578rm5 71 25 most most RBS cord-011310-fm578rm5 71 26 common common JJ cord-011310-fm578rm5 71 27 symptoms symptom NNS cord-011310-fm578rm5 71 28 are be VBP cord-011310-fm578rm5 71 29 diarrhea diarrhea JJ cord-011310-fm578rm5 71 30 , , , cord-011310-fm578rm5 71 31 nausea nausea NN cord-011310-fm578rm5 71 32 and/or and/or CC cord-011310-fm578rm5 71 33 vomiting vomiting NN cord-011310-fm578rm5 71 34 , , , cord-011310-fm578rm5 71 35 epigastric epigastric JJ cord-011310-fm578rm5 71 36 pain pain NN cord-011310-fm578rm5 71 37 , , , cord-011310-fm578rm5 71 38 and and CC cord-011310-fm578rm5 71 39 altered alter VBN cord-011310-fm578rm5 71 40 taste taste NN cord-011310-fm578rm5 71 41 [ [ -LRB- cord-011310-fm578rm5 71 42 34 34 CD cord-011310-fm578rm5 71 43 ] ] -RRB- cord-011310-fm578rm5 71 44 . . . cord-011310-fm578rm5 72 1 A a DT cord-011310-fm578rm5 72 2 large large JJ cord-011310-fm578rm5 72 3 systemic systemic JJ cord-011310-fm578rm5 72 4 review review NN cord-011310-fm578rm5 72 5 performed perform VBN cord-011310-fm578rm5 72 6 in in IN cord-011310-fm578rm5 72 7 2004 2004 CD cord-011310-fm578rm5 72 8 demonstrated demonstrate VBD cord-011310-fm578rm5 72 9 adverse adverse JJ cord-011310-fm578rm5 72 10 effects effect NNS cord-011310-fm578rm5 72 11 in in IN cord-011310-fm578rm5 72 12 22 22 CD cord-011310-fm578rm5 72 13 % % NN cord-011310-fm578rm5 72 14 of of IN cord-011310-fm578rm5 72 15 the the DT cord-011310-fm578rm5 72 16 subjects subject NNS cord-011310-fm578rm5 72 17 receiving receive VBG cord-011310-fm578rm5 72 18 eradication eradication NN cord-011310-fm578rm5 72 19 therapy therapy NN cord-011310-fm578rm5 72 20 for for IN cord-011310-fm578rm5 72 21 peptic peptic JJ cord-011310-fm578rm5 72 22 ulcer ulcer NN cord-011310-fm578rm5 72 23 compared compare VBN cord-011310-fm578rm5 72 24 to to IN cord-011310-fm578rm5 72 25 8 8 CD cord-011310-fm578rm5 72 26 % % NN cord-011310-fm578rm5 72 27 in in IN cord-011310-fm578rm5 72 28 patients patient NNS cord-011310-fm578rm5 72 29 on on IN cord-011310-fm578rm5 72 30 a a DT cord-011310-fm578rm5 72 31 proton proton NN cord-011310-fm578rm5 72 32 pump pump NN cord-011310-fm578rm5 72 33 inhibitor inhibitor NN cord-011310-fm578rm5 72 34 ( ( -LRB- cord-011310-fm578rm5 72 35 PPI PPI NNP cord-011310-fm578rm5 72 36 ) ) -RRB- cord-011310-fm578rm5 72 37 or or CC cord-011310-fm578rm5 72 38 no no DT cord-011310-fm578rm5 72 39 treatment treatment NN cord-011310-fm578rm5 72 40 ( ( -LRB- cord-011310-fm578rm5 72 41 RR RR NNP cord-011310-fm578rm5 72 42 2.28 2.28 CD cord-011310-fm578rm5 72 43 ; ; : cord-011310-fm578rm5 72 44 95 95 CD cord-011310-fm578rm5 72 45 % % NN cord-011310-fm578rm5 72 46 CI ci NN cord-011310-fm578rm5 72 47 : : : cord-011310-fm578rm5 72 48 1.72 1.72 CD cord-011310-fm578rm5 72 49 to to IN cord-011310-fm578rm5 72 50 3.02 3.02 CD cord-011310-fm578rm5 72 51 ) ) -RRB- cord-011310-fm578rm5 72 52 [ [ -LRB- cord-011310-fm578rm5 72 53 34 34 CD cord-011310-fm578rm5 72 54 ] ] -RRB- cord-011310-fm578rm5 72 55 . . . cord-011310-fm578rm5 73 1 Treatment treatment NN cord-011310-fm578rm5 73 2 with with IN cord-011310-fm578rm5 73 3 oral oral JJ cord-011310-fm578rm5 73 4 and and CC cord-011310-fm578rm5 73 5 parenteral parenteral JJ cord-011310-fm578rm5 73 6 antibiotics antibiotic NNS cord-011310-fm578rm5 73 7 results result VBZ cord-011310-fm578rm5 73 8 in in IN cord-011310-fm578rm5 73 9 a a DT cord-011310-fm578rm5 73 10 rapid rapid JJ cord-011310-fm578rm5 73 11 and and CC cord-011310-fm578rm5 73 12 significant significant JJ cord-011310-fm578rm5 73 13 alteration alteration NN cord-011310-fm578rm5 73 14 of of IN cord-011310-fm578rm5 73 15 the the DT cord-011310-fm578rm5 73 16 intestinal intestinal JJ cord-011310-fm578rm5 73 17 microbiota microbiota NN cord-011310-fm578rm5 73 18 . . . cord-011310-fm578rm5 74 1 The the DT cord-011310-fm578rm5 74 2 most most RBS cord-011310-fm578rm5 74 3 obvious obvious JJ cord-011310-fm578rm5 74 4 outcome outcome NN cord-011310-fm578rm5 74 5 of of IN cord-011310-fm578rm5 74 6 disruption disruption NN cord-011310-fm578rm5 74 7 of of IN cord-011310-fm578rm5 74 8 normal normal JJ cord-011310-fm578rm5 74 9 gut gut NN cord-011310-fm578rm5 74 10 microbiome microbiome NN cord-011310-fm578rm5 74 11 is be VBZ cord-011310-fm578rm5 74 12 Clostridium clostridium NN cord-011310-fm578rm5 74 13 difficile difficile NN cord-011310-fm578rm5 74 14 infection infection NN cord-011310-fm578rm5 74 15 ( ( -LRB- cord-011310-fm578rm5 74 16 CDI CDI NNP cord-011310-fm578rm5 74 17 ) ) -RRB- cord-011310-fm578rm5 74 18 . . . cord-011310-fm578rm5 75 1 CDI CDI NNP cord-011310-fm578rm5 75 2 is be VBZ cord-011310-fm578rm5 75 3 a a DT cord-011310-fm578rm5 75 4 major major JJ cord-011310-fm578rm5 75 5 threat threat NN cord-011310-fm578rm5 75 6 to to IN cord-011310-fm578rm5 75 7 both both DT cord-011310-fm578rm5 75 8 outpatients outpatient NNS cord-011310-fm578rm5 75 9 and and CC cord-011310-fm578rm5 75 10 those those DT cord-011310-fm578rm5 75 11 hospitalized hospitalize VBN cord-011310-fm578rm5 75 12 . . . cord-011310-fm578rm5 76 1 Although although IN cord-011310-fm578rm5 76 2 any any DT cord-011310-fm578rm5 76 3 antimicrobium antimicrobium NN cord-011310-fm578rm5 76 4 can can MD cord-011310-fm578rm5 76 5 predispose predispose VB cord-011310-fm578rm5 76 6 a a DT cord-011310-fm578rm5 76 7 patient patient NN cord-011310-fm578rm5 76 8 to to IN cord-011310-fm578rm5 76 9 CDI CDI NNP cord-011310-fm578rm5 76 10 , , , cord-011310-fm578rm5 76 11 the the DT cord-011310-fm578rm5 76 12 risk risk NN cord-011310-fm578rm5 76 13 is be VBZ cord-011310-fm578rm5 76 14 especially especially RB cord-011310-fm578rm5 76 15 great great JJ cord-011310-fm578rm5 76 16 when when WRB cord-011310-fm578rm5 76 17 using use VBG cord-011310-fm578rm5 76 18 broad broad JJ cord-011310-fm578rm5 76 19 - - HYPH cord-011310-fm578rm5 76 20 spectrum spectrum NN cord-011310-fm578rm5 76 21 antimicrobials antimicrobial NNS cord-011310-fm578rm5 76 22 , , , cord-011310-fm578rm5 76 23 which which WDT cord-011310-fm578rm5 76 24 disrupt disrupt VBP cord-011310-fm578rm5 76 25 normal normal JJ cord-011310-fm578rm5 76 26 enteric enteric JJ cord-011310-fm578rm5 76 27 flora flora NNS cord-011310-fm578rm5 76 28 [ [ -LRB- cord-011310-fm578rm5 76 29 35 35 CD cord-011310-fm578rm5 76 30 ] ] -RRB- cord-011310-fm578rm5 76 31 . . . cord-011310-fm578rm5 77 1 Prolonged prolonged JJ cord-011310-fm578rm5 77 2 treatment treatment NN cord-011310-fm578rm5 77 3 with with IN cord-011310-fm578rm5 77 4 antimicrobial antimicrobial JJ cord-011310-fm578rm5 77 5 agents agent NNS cord-011310-fm578rm5 77 6 is be VBZ cord-011310-fm578rm5 77 7 also also RB cord-011310-fm578rm5 77 8 associated associate VBN cord-011310-fm578rm5 77 9 with with IN cord-011310-fm578rm5 77 10 an an DT cord-011310-fm578rm5 77 11 increased increase VBN cord-011310-fm578rm5 77 12 risk risk NN cord-011310-fm578rm5 77 13 of of IN cord-011310-fm578rm5 77 14 CDI CDI NNP cord-011310-fm578rm5 77 15 by by IN cord-011310-fm578rm5 77 16 extending extend VBG cord-011310-fm578rm5 77 17 the the DT cord-011310-fm578rm5 77 18 time time NN cord-011310-fm578rm5 77 19 disruption disruption NN cord-011310-fm578rm5 77 20 of of IN cord-011310-fm578rm5 77 21 normal normal JJ cord-011310-fm578rm5 77 22 enteric enteric JJ cord-011310-fm578rm5 77 23 flora flora NNS cord-011310-fm578rm5 77 24 [ [ -LRB- cord-011310-fm578rm5 77 25 36 36 CD cord-011310-fm578rm5 77 26 ] ] -RRB- cord-011310-fm578rm5 77 27 . . . cord-011310-fm578rm5 78 1 Although although IN cord-011310-fm578rm5 78 2 not not RB cord-011310-fm578rm5 78 3 being be VBG cord-011310-fm578rm5 78 4 a a DT cord-011310-fm578rm5 78 5 typical typical JJ cord-011310-fm578rm5 78 6 adverse adverse JJ cord-011310-fm578rm5 78 7 event event NN cord-011310-fm578rm5 78 8 , , , cord-011310-fm578rm5 78 9 a a DT cord-011310-fm578rm5 78 10 number number NN cord-011310-fm578rm5 78 11 of of IN cord-011310-fm578rm5 78 12 cases case NNS cord-011310-fm578rm5 78 13 have have VBP cord-011310-fm578rm5 78 14 been be VBN cord-011310-fm578rm5 78 15 published publish VBN cord-011310-fm578rm5 78 16 on on IN cord-011310-fm578rm5 78 17 CDI CDI NNP cord-011310-fm578rm5 78 18 after after IN cord-011310-fm578rm5 78 19 eradication eradication NN cord-011310-fm578rm5 78 20 therapy therapy NN cord-011310-fm578rm5 78 21 of of IN cord-011310-fm578rm5 78 22 H. H. NNP cord-011310-fm578rm5 78 23 pylori pylori NN cord-011310-fm578rm5 78 24 [ [ -LRB- cord-011310-fm578rm5 78 25 37 37 CD cord-011310-fm578rm5 78 26 ] ] -RRB- cord-011310-fm578rm5 78 27 . . . cord-011310-fm578rm5 79 1 Awareness awareness NN cord-011310-fm578rm5 79 2 of of IN cord-011310-fm578rm5 79 3 the the DT cord-011310-fm578rm5 79 4 complication complication NN cord-011310-fm578rm5 79 5 is be VBZ cord-011310-fm578rm5 79 6 particularly particularly RB cord-011310-fm578rm5 79 7 important important JJ cord-011310-fm578rm5 79 8 when when WRB cord-011310-fm578rm5 79 9 both both DT cord-011310-fm578rm5 79 10 duration duration NN cord-011310-fm578rm5 79 11 and and CC cord-011310-fm578rm5 79 12 indications indication NNS cord-011310-fm578rm5 79 13 for for IN cord-011310-fm578rm5 79 14 H. h. NN cord-011310-fm578rm5 79 15 pylori pylori NN cord-011310-fm578rm5 79 16 eradication eradication NN cord-011310-fm578rm5 79 17 therapy therapy NN cord-011310-fm578rm5 79 18 have have VBP cord-011310-fm578rm5 79 19 been be VBN cord-011310-fm578rm5 79 20 extended extend VBN cord-011310-fm578rm5 79 21 . . . cord-011310-fm578rm5 80 1 Significant significant JJ cord-011310-fm578rm5 80 2 perturbation perturbation NN cord-011310-fm578rm5 80 3 of of IN cord-011310-fm578rm5 80 4 the the DT cord-011310-fm578rm5 80 5 gut gut NN cord-011310-fm578rm5 80 6 microbiome microbiome NN cord-011310-fm578rm5 80 7 might may MD cord-011310-fm578rm5 80 8 follow follow VB cord-011310-fm578rm5 80 9 the the DT cord-011310-fm578rm5 80 10 use use NN cord-011310-fm578rm5 80 11 of of IN cord-011310-fm578rm5 80 12 antibiotics antibiotic NNS cord-011310-fm578rm5 80 13 ; ; : cord-011310-fm578rm5 80 14 however however RB cord-011310-fm578rm5 80 15 , , , cord-011310-fm578rm5 80 16 in in IN cord-011310-fm578rm5 80 17 the the DT cord-011310-fm578rm5 80 18 majority majority NN cord-011310-fm578rm5 80 19 of of IN cord-011310-fm578rm5 80 20 cases case NNS cord-011310-fm578rm5 80 21 the the DT cord-011310-fm578rm5 80 22 gut gut NN cord-011310-fm578rm5 80 23 microflora microflora NN cord-011310-fm578rm5 80 24 would would MD cord-011310-fm578rm5 80 25 be be VB cord-011310-fm578rm5 80 26 expected expect VBN cord-011310-fm578rm5 80 27 to to TO cord-011310-fm578rm5 80 28 return return VB cord-011310-fm578rm5 80 29 to to IN cord-011310-fm578rm5 80 30 its -PRON- PRP$ cord-011310-fm578rm5 80 31 initial initial JJ cord-011310-fm578rm5 80 32 state state NN cord-011310-fm578rm5 80 33 within within IN cord-011310-fm578rm5 80 34 a a DT cord-011310-fm578rm5 80 35 few few JJ cord-011310-fm578rm5 80 36 months month NNS cord-011310-fm578rm5 80 37 [ [ -LRB- cord-011310-fm578rm5 80 38 38 38 CD cord-011310-fm578rm5 80 39 , , , cord-011310-fm578rm5 80 40 39 39 CD cord-011310-fm578rm5 80 41 ] ] -RRB- cord-011310-fm578rm5 80 42 . . . cord-011310-fm578rm5 81 1 Resistome Resistome NNP cord-011310-fm578rm5 81 2 is be VBZ cord-011310-fm578rm5 81 3 defined define VBN cord-011310-fm578rm5 81 4 as as IN cord-011310-fm578rm5 81 5 a a DT cord-011310-fm578rm5 81 6 collection collection NN cord-011310-fm578rm5 81 7 of of IN cord-011310-fm578rm5 81 8 all all DT cord-011310-fm578rm5 81 9 antibiotic antibiotic JJ cord-011310-fm578rm5 81 10 resistance resistance NN cord-011310-fm578rm5 81 11 genes gene NNS cord-011310-fm578rm5 81 12 and and CC cord-011310-fm578rm5 81 13 their -PRON- PRP$ cord-011310-fm578rm5 81 14 precursors precursor NNS cord-011310-fm578rm5 81 15 in in IN cord-011310-fm578rm5 81 16 both both CC cord-011310-fm578rm5 81 17 pathogenetic pathogenetic JJ cord-011310-fm578rm5 81 18 and and CC cord-011310-fm578rm5 81 19 non non JJ cord-011310-fm578rm5 81 20 - - JJ cord-011310-fm578rm5 81 21 pathogenic pathogenic JJ cord-011310-fm578rm5 81 22 bacteria bacteria NNS cord-011310-fm578rm5 81 23 [ [ -LRB- cord-011310-fm578rm5 81 24 40 40 CD cord-011310-fm578rm5 81 25 ] ] -RRB- cord-011310-fm578rm5 81 26 . . . cord-011310-fm578rm5 82 1 The the DT cord-011310-fm578rm5 82 2 gut gut NN cord-011310-fm578rm5 82 3 microbiota microbiota NN cord-011310-fm578rm5 82 4 is be VBZ cord-011310-fm578rm5 82 5 a a DT cord-011310-fm578rm5 82 6 large large JJ cord-011310-fm578rm5 82 7 reservoir reservoir NN cord-011310-fm578rm5 82 8 of of IN cord-011310-fm578rm5 82 9 antibiotic antibiotic JJ cord-011310-fm578rm5 82 10 - - HYPH cord-011310-fm578rm5 82 11 resistance resistance NN cord-011310-fm578rm5 82 12 genes gene NNS cord-011310-fm578rm5 82 13 [ [ -LRB- cord-011310-fm578rm5 82 14 41 41 CD cord-011310-fm578rm5 82 15 ] ] -RRB- cord-011310-fm578rm5 82 16 ; ; : cord-011310-fm578rm5 82 17 an an DT cord-011310-fm578rm5 82 18 average average JJ cord-011310-fm578rm5 82 19 number number NN cord-011310-fm578rm5 82 20 of of IN cord-011310-fm578rm5 82 21 21 21 CD cord-011310-fm578rm5 82 22 such such JJ cord-011310-fm578rm5 82 23 genes gene NNS cord-011310-fm578rm5 82 24 per per IN cord-011310-fm578rm5 82 25 sample sample NN cord-011310-fm578rm5 82 26 has have VBZ cord-011310-fm578rm5 82 27 been be VBN cord-011310-fm578rm5 82 28 reported report VBN cord-011310-fm578rm5 82 29 [ [ -LRB- cord-011310-fm578rm5 82 30 42 42 CD cord-011310-fm578rm5 82 31 ] ] -RRB- cord-011310-fm578rm5 82 32 . . . cord-011310-fm578rm5 83 1 Many many JJ cord-011310-fm578rm5 83 2 earlier early RBR cord-011310-fm578rm5 83 3 and and CC cord-011310-fm578rm5 83 4 more more JJR cord-011310-fm578rm5 83 5 recent recent JJ cord-011310-fm578rm5 83 6 studies study NNS cord-011310-fm578rm5 83 7 have have VBP cord-011310-fm578rm5 83 8 suggested suggest VBN cord-011310-fm578rm5 83 9 long long RB cord-011310-fm578rm5 83 10 - - HYPH cord-011310-fm578rm5 83 11 lasting last VBG cord-011310-fm578rm5 83 12 persistence persistence NN cord-011310-fm578rm5 83 13 of of IN cord-011310-fm578rm5 83 14 resistant resistant JJ cord-011310-fm578rm5 83 15 pharyngeal pharyngeal NN cord-011310-fm578rm5 83 16 and/or and/or CC cord-011310-fm578rm5 83 17 gut gut NN cord-011310-fm578rm5 83 18 bacteria bacteria NNS cord-011310-fm578rm5 83 19 following follow VBG cord-011310-fm578rm5 83 20 the the DT cord-011310-fm578rm5 83 21 use use NN cord-011310-fm578rm5 83 22 of of IN cord-011310-fm578rm5 83 23 traditional traditional JJ cord-011310-fm578rm5 83 24 antibiotics antibiotic NNS cord-011310-fm578rm5 83 25 used use VBN cord-011310-fm578rm5 83 26 to to TO cord-011310-fm578rm5 83 27 eradicate eradicate VB cord-011310-fm578rm5 83 28 H. H. NNP cord-011310-fm578rm5 83 29 pylori pylori NN cord-011310-fm578rm5 83 30 . . . cord-011310-fm578rm5 84 1 One one CD cord-011310-fm578rm5 84 2 - - HYPH cord-011310-fm578rm5 84 3 week week NN cord-011310-fm578rm5 84 4 treatment treatment NN cord-011310-fm578rm5 84 5 of of IN cord-011310-fm578rm5 84 6 healthy healthy JJ cord-011310-fm578rm5 84 7 volunteers volunteer NNS cord-011310-fm578rm5 84 8 with with IN cord-011310-fm578rm5 84 9 macrolides macrolide NNS cord-011310-fm578rm5 84 10 ( ( -LRB- cord-011310-fm578rm5 84 11 azithromycin azithromycin NNP cord-011310-fm578rm5 84 12 or or CC cord-011310-fm578rm5 84 13 clarithromycin clarithromycin NNP cord-011310-fm578rm5 84 14 ) ) -RRB- cord-011310-fm578rm5 84 15 has have VBZ cord-011310-fm578rm5 84 16 been be VBN cord-011310-fm578rm5 84 17 associated associate VBN cord-011310-fm578rm5 84 18 to to IN cord-011310-fm578rm5 84 19 a a DT cord-011310-fm578rm5 84 20 significantly significantly RB cord-011310-fm578rm5 84 21 increased increase VBN cord-011310-fm578rm5 84 22 proportion proportion NN cord-011310-fm578rm5 84 23 of of IN cord-011310-fm578rm5 84 24 macrolide macrolide JJ cord-011310-fm578rm5 84 25 - - HYPH cord-011310-fm578rm5 84 26 resistant resistant JJ cord-011310-fm578rm5 84 27 streptococci streptococcus NNS cord-011310-fm578rm5 84 28 in in IN cord-011310-fm578rm5 84 29 the the DT cord-011310-fm578rm5 84 30 pharynx pharynx NN cord-011310-fm578rm5 84 31 compared compare VBN cord-011310-fm578rm5 84 32 to to IN cord-011310-fm578rm5 84 33 a a DT cord-011310-fm578rm5 84 34 placebo placebo NN cord-011310-fm578rm5 84 35 - - HYPH cord-011310-fm578rm5 84 36 treated treat VBN cord-011310-fm578rm5 84 37 group group NN cord-011310-fm578rm5 84 38 ; ; : cord-011310-fm578rm5 84 39 resistant resistant JJ cord-011310-fm578rm5 84 40 streptococci streptococcus NNS cord-011310-fm578rm5 84 41 were be VBD cord-011310-fm578rm5 84 42 present present JJ cord-011310-fm578rm5 84 43 for for IN cord-011310-fm578rm5 84 44 up up IN cord-011310-fm578rm5 84 45 to to TO cord-011310-fm578rm5 84 46 180 180 CD cord-011310-fm578rm5 84 47 days day NNS cord-011310-fm578rm5 84 48 following follow VBG cord-011310-fm578rm5 84 49 treatment treatment NN cord-011310-fm578rm5 84 50 [ [ -LRB- cord-011310-fm578rm5 84 51 16 16 CD cord-011310-fm578rm5 84 52 ] ] -RRB- cord-011310-fm578rm5 84 53 . . . cord-011310-fm578rm5 85 1 Similar similar JJ cord-011310-fm578rm5 85 2 data datum NNS cord-011310-fm578rm5 85 3 on on IN cord-011310-fm578rm5 85 4 macrolide macrolide JJ cord-011310-fm578rm5 85 5 - - HYPH cord-011310-fm578rm5 85 6 resistant resistant JJ cord-011310-fm578rm5 85 7 streptococci streptococcus NNS cord-011310-fm578rm5 85 8 persistence persistence NN cord-011310-fm578rm5 85 9 in in IN cord-011310-fm578rm5 85 10 the the DT cord-011310-fm578rm5 85 11 pharynx pharynx NN cord-011310-fm578rm5 85 12 for for IN cord-011310-fm578rm5 85 13 more more JJR cord-011310-fm578rm5 85 14 than than IN cord-011310-fm578rm5 85 15 1 1 CD cord-011310-fm578rm5 85 16 year year NN cord-011310-fm578rm5 85 17 in in IN cord-011310-fm578rm5 85 18 patients patient NNS cord-011310-fm578rm5 85 19 receiving receive VBG cord-011310-fm578rm5 85 20 clarithromycin clarithromycin NNS cord-011310-fm578rm5 85 21 - - HYPH cord-011310-fm578rm5 85 22 containing contain VBG cord-011310-fm578rm5 85 23 H. h. NN cord-011310-fm578rm5 85 24 pylori pylori NN cord-011310-fm578rm5 85 25 eradication eradication NN cord-011310-fm578rm5 85 26 regimens regimen NNS cord-011310-fm578rm5 85 27 have have VBP cord-011310-fm578rm5 85 28 been be VBN cord-011310-fm578rm5 85 29 reported report VBN cord-011310-fm578rm5 85 30 by by IN cord-011310-fm578rm5 85 31 others other NNS cord-011310-fm578rm5 85 32 [ [ -LRB- cord-011310-fm578rm5 85 33 43 43 CD cord-011310-fm578rm5 85 34 ] ] -RRB- cord-011310-fm578rm5 85 35 . . . cord-011310-fm578rm5 86 1 Another another DT cord-011310-fm578rm5 86 2 study study NN cord-011310-fm578rm5 86 3 has have VBZ cord-011310-fm578rm5 86 4 addressed address VBN cord-011310-fm578rm5 86 5 the the DT cord-011310-fm578rm5 86 6 presence presence NN cord-011310-fm578rm5 86 7 of of IN cord-011310-fm578rm5 86 8 resistant resistant JJ cord-011310-fm578rm5 86 9 Staphylococcus Staphylococcus NNP cord-011310-fm578rm5 86 10 , , , cord-011310-fm578rm5 86 11 Streptococcus Streptococcus NNP cord-011310-fm578rm5 86 12 , , , cord-011310-fm578rm5 86 13 Enterococcus Enterococcus NNP cord-011310-fm578rm5 86 14 and and CC cord-011310-fm578rm5 86 15 Bacteroides Bacteroides NNP cord-011310-fm578rm5 86 16 spp spp NNS cord-011310-fm578rm5 86 17 . . . cord-011310-fm578rm5 87 1 in in IN cord-011310-fm578rm5 87 2 samples sample NNS cord-011310-fm578rm5 87 3 from from IN cord-011310-fm578rm5 87 4 nostrils nostril NNS cord-011310-fm578rm5 87 5 , , , cord-011310-fm578rm5 87 6 throat throat NN cord-011310-fm578rm5 87 7 and and CC cord-011310-fm578rm5 87 8 feces fece NNS cord-011310-fm578rm5 87 9 before before RB cord-011310-fm578rm5 87 10 , , , cord-011310-fm578rm5 87 11 2 2 CD cord-011310-fm578rm5 87 12 weeks week NNS cord-011310-fm578rm5 87 13 and and CC cord-011310-fm578rm5 87 14 1 1 CD cord-011310-fm578rm5 87 15 year year NN cord-011310-fm578rm5 87 16 following follow VBG cord-011310-fm578rm5 87 17 triple triple JJ cord-011310-fm578rm5 87 18 H. h. NN cord-011310-fm578rm5 87 19 pylori pylori NN cord-011310-fm578rm5 87 20 eradication eradication NN cord-011310-fm578rm5 87 21 therapy therapy NN cord-011310-fm578rm5 87 22 ( ( -LRB- cord-011310-fm578rm5 87 23 clarithromycin clarithromycin NNP cord-011310-fm578rm5 87 24 , , , cord-011310-fm578rm5 87 25 metronidazole metronidazole NNP cord-011310-fm578rm5 87 26 and and CC cord-011310-fm578rm5 87 27 omeprazole omeprazole NN cord-011310-fm578rm5 87 28 for for IN cord-011310-fm578rm5 87 29 7 7 CD cord-011310-fm578rm5 87 30 days day NNS cord-011310-fm578rm5 87 31 ) ) -RRB- cord-011310-fm578rm5 87 32 in in IN cord-011310-fm578rm5 87 33 a a DT cord-011310-fm578rm5 87 34 group group NN cord-011310-fm578rm5 87 35 with with IN cord-011310-fm578rm5 87 36 peptic peptic JJ cord-011310-fm578rm5 87 37 ulcer ulcer NN cord-011310-fm578rm5 87 38 disease disease NN cord-011310-fm578rm5 87 39 , , , cord-011310-fm578rm5 87 40 as as RB cord-011310-fm578rm5 87 41 well well RB cord-011310-fm578rm5 87 42 as as IN cord-011310-fm578rm5 87 43 a a DT cord-011310-fm578rm5 87 44 control control NN cord-011310-fm578rm5 87 45 group group NN cord-011310-fm578rm5 87 46 not not RB cord-011310-fm578rm5 87 47 receiving receive VBG cord-011310-fm578rm5 87 48 this this DT cord-011310-fm578rm5 87 49 treatment treatment NN cord-011310-fm578rm5 87 50 [ [ -LRB- cord-011310-fm578rm5 87 51 44 44 CD cord-011310-fm578rm5 87 52 ] ] -RRB- cord-011310-fm578rm5 87 53 . . . cord-011310-fm578rm5 88 1 Resistant resistant JJ cord-011310-fm578rm5 88 2 isolates isolate NNS cord-011310-fm578rm5 88 3 , , , cord-011310-fm578rm5 88 4 in in IN cord-011310-fm578rm5 88 5 particular particular JJ cord-011310-fm578rm5 88 6 of of IN cord-011310-fm578rm5 88 7 Staphylococci Staphylococci NNP cord-011310-fm578rm5 88 8 and and CC cord-011310-fm578rm5 88 9 Streptococci Streptococci NNP cord-011310-fm578rm5 88 10 were be VBD cord-011310-fm578rm5 88 11 higher high JJR cord-011310-fm578rm5 88 12 after after IN cord-011310-fm578rm5 88 13 1 1 CD cord-011310-fm578rm5 88 14 year year NN cord-011310-fm578rm5 88 15 , , , cord-011310-fm578rm5 88 16 but but CC cord-011310-fm578rm5 88 17 not not RB cord-011310-fm578rm5 88 18 in in IN cord-011310-fm578rm5 88 19 the the DT cord-011310-fm578rm5 88 20 control control NN cord-011310-fm578rm5 88 21 group group NN cord-011310-fm578rm5 88 22 . . . cord-011310-fm578rm5 89 1 Another another DT cord-011310-fm578rm5 89 2 study study NN cord-011310-fm578rm5 89 3 based base VBN cord-011310-fm578rm5 89 4 on on IN cord-011310-fm578rm5 89 5 the the DT cord-011310-fm578rm5 89 6 same same JJ cord-011310-fm578rm5 89 7 patient patient NN cord-011310-fm578rm5 89 8 data datum NNS cord-011310-fm578rm5 89 9 demonstrated demonstrate VBD cord-011310-fm578rm5 89 10 that that IN cord-011310-fm578rm5 89 11 this this DT cord-011310-fm578rm5 89 12 treatment treatment NN cord-011310-fm578rm5 89 13 facilitated facilitate VBD cord-011310-fm578rm5 89 14 the the DT cord-011310-fm578rm5 89 15 selection selection NN cord-011310-fm578rm5 89 16 of of IN cord-011310-fm578rm5 89 17 highly highly RB cord-011310-fm578rm5 89 18 resistant resistant JJ cord-011310-fm578rm5 89 19 enterococci enterococci NNS cord-011310-fm578rm5 89 20 present present NN cord-011310-fm578rm5 89 21 , , , cord-011310-fm578rm5 89 22 even even RB cord-011310-fm578rm5 89 23 3 3 CD cord-011310-fm578rm5 89 24 years year NNS cord-011310-fm578rm5 89 25 after after IN cord-011310-fm578rm5 89 26 treatment treatment NN cord-011310-fm578rm5 89 27 [ [ -LRB- cord-011310-fm578rm5 89 28 45 45 CD cord-011310-fm578rm5 89 29 ] ] -RRB- cord-011310-fm578rm5 89 30 . . . cord-011310-fm578rm5 90 1 The the DT cord-011310-fm578rm5 90 2 same same JJ cord-011310-fm578rm5 90 3 group group NN cord-011310-fm578rm5 90 4 has have VBZ cord-011310-fm578rm5 90 5 also also RB cord-011310-fm578rm5 90 6 addressed address VBN cord-011310-fm578rm5 90 7 erm(B erm(B NNP cord-011310-fm578rm5 90 8 ) ) -RRB- cord-011310-fm578rm5 91 1 gene gene NN cord-011310-fm578rm5 91 2 levels level NNS cord-011310-fm578rm5 91 3 ( ( -LRB- cord-011310-fm578rm5 91 4 one one CD cord-011310-fm578rm5 91 5 of of IN cord-011310-fm578rm5 91 6 the the DT cord-011310-fm578rm5 91 7 mechanisms mechanism NNS cord-011310-fm578rm5 91 8 for for IN cord-011310-fm578rm5 91 9 macrolide macrolide JJ cord-011310-fm578rm5 91 10 resistance resistance NN cord-011310-fm578rm5 91 11 ) ) -RRB- cord-011310-fm578rm5 91 12 both both CC cord-011310-fm578rm5 91 13 in in IN cord-011310-fm578rm5 91 14 throat throat NN cord-011310-fm578rm5 91 15 and and CC cord-011310-fm578rm5 91 16 fecal fecal JJ cord-011310-fm578rm5 91 17 samples sample NNS cord-011310-fm578rm5 91 18 . . . cord-011310-fm578rm5 92 1 These these DT cord-011310-fm578rm5 92 2 levels level NNS cord-011310-fm578rm5 92 3 increased increase VBD cord-011310-fm578rm5 92 4 dramatically dramatically RB cord-011310-fm578rm5 92 5 by by IN cord-011310-fm578rm5 92 6 3 3 CD cord-011310-fm578rm5 92 7 - - SYM cord-011310-fm578rm5 92 8 5 5 CD cord-011310-fm578rm5 92 9 orders order NNS cord-011310-fm578rm5 92 10 of of IN cord-011310-fm578rm5 92 11 magnitude magnitude NN cord-011310-fm578rm5 92 12 immediately immediately RB cord-011310-fm578rm5 92 13 after after IN cord-011310-fm578rm5 92 14 antibiotic antibiotic JJ cord-011310-fm578rm5 92 15 treatment treatment NN cord-011310-fm578rm5 92 16 . . . cord-011310-fm578rm5 93 1 In in IN cord-011310-fm578rm5 93 2 a a DT cord-011310-fm578rm5 93 3 proportion proportion NN cord-011310-fm578rm5 93 4 of of IN cord-011310-fm578rm5 93 5 the the DT cord-011310-fm578rm5 93 6 subjects subject NNS cord-011310-fm578rm5 93 7 , , , cord-011310-fm578rm5 93 8 erm(B erm(B NNP cord-011310-fm578rm5 93 9 ) ) -RRB- cord-011310-fm578rm5 93 10 remained remain VBD cord-011310-fm578rm5 93 11 elevated elevated JJ cord-011310-fm578rm5 93 12 4 4 CD cord-011310-fm578rm5 93 13 years year NNS cord-011310-fm578rm5 93 14 after after IN cord-011310-fm578rm5 93 15 treatment treatment NN cord-011310-fm578rm5 93 16 [ [ -LRB- cord-011310-fm578rm5 93 17 46 46 CD cord-011310-fm578rm5 93 18 ] ] -RRB- cord-011310-fm578rm5 93 19 . . . cord-011310-fm578rm5 94 1 However however RB cord-011310-fm578rm5 94 2 , , , cord-011310-fm578rm5 94 3 the the DT cord-011310-fm578rm5 94 4 small small JJ cord-011310-fm578rm5 94 5 sample sample NN cord-011310-fm578rm5 94 6 of of IN cord-011310-fm578rm5 94 7 subjects subject NNS cord-011310-fm578rm5 94 8 in in IN cord-011310-fm578rm5 94 9 this this DT cord-011310-fm578rm5 94 10 study study NN cord-011310-fm578rm5 94 11 should should MD cord-011310-fm578rm5 94 12 be be VB cord-011310-fm578rm5 94 13 noted note VBN cord-011310-fm578rm5 94 14 . . . cord-011310-fm578rm5 95 1 More more RBR cord-011310-fm578rm5 95 2 recently recently RB cord-011310-fm578rm5 95 3 , , , cord-011310-fm578rm5 95 4 larger large JJR cord-011310-fm578rm5 95 5 studies study NNS cord-011310-fm578rm5 95 6 applying apply VBG cord-011310-fm578rm5 95 7 16S 16S NNP cord-011310-fm578rm5 95 8 rRNA rRNA NNP cord-011310-fm578rm5 95 9 gene gene NN cord-011310-fm578rm5 95 10 and and CC cord-011310-fm578rm5 95 11 metagenomic metagenomic NNP cord-011310-fm578rm5 95 12 sequencing sequencing NN cord-011310-fm578rm5 95 13 have have VBP cord-011310-fm578rm5 95 14 been be VBN cord-011310-fm578rm5 95 15 reported report VBN cord-011310-fm578rm5 95 16 by by IN cord-011310-fm578rm5 95 17 Yap Yap NNP cord-011310-fm578rm5 95 18 et et NNP cord-011310-fm578rm5 95 19 al al NNP cord-011310-fm578rm5 95 20 . . . cord-011310-fm578rm5 96 1 [ [ -LRB- cord-011310-fm578rm5 96 2 15 15 CD cord-011310-fm578rm5 96 3 ] ] -RRB- cord-011310-fm578rm5 96 4 who who WP cord-011310-fm578rm5 96 5 investigated investigate VBD cord-011310-fm578rm5 96 6 stool stool NN cord-011310-fm578rm5 96 7 samples sample NNS cord-011310-fm578rm5 96 8 in in IN cord-011310-fm578rm5 96 9 17-year 17-year JJ cord-011310-fm578rm5 96 10 - - HYPH cord-011310-fm578rm5 96 11 old old JJ cord-011310-fm578rm5 96 12 volunteers volunteer NNS cord-011310-fm578rm5 96 13 from from IN cord-011310-fm578rm5 96 14 Malaysia Malaysia NNP cord-011310-fm578rm5 96 15 before before IN cord-011310-fm578rm5 96 16 H. H. NNP cord-011310-fm578rm5 96 17 pylori pylori NN cord-011310-fm578rm5 96 18 eradication eradication NN cord-011310-fm578rm5 96 19 , , , cord-011310-fm578rm5 96 20 and and CC cord-011310-fm578rm5 96 21 at at IN cord-011310-fm578rm5 96 22 6 6 CD cord-011310-fm578rm5 96 23 , , , cord-011310-fm578rm5 96 24 12 12 CD cord-011310-fm578rm5 96 25 , , , cord-011310-fm578rm5 96 26 18 18 CD cord-011310-fm578rm5 96 27 months month NNS cord-011310-fm578rm5 96 28 thereafter thereafter RB cord-011310-fm578rm5 96 29 . . . cord-011310-fm578rm5 97 1 Despite despite IN cord-011310-fm578rm5 97 2 microbial microbial JJ cord-011310-fm578rm5 97 3 diversity diversity NN cord-011310-fm578rm5 97 4 was be VBD cord-011310-fm578rm5 97 5 similar similar JJ cord-011310-fm578rm5 97 6 pre pre JJ cord-011310-fm578rm5 97 7 - - JJ cord-011310-fm578rm5 97 8 and and CC cord-011310-fm578rm5 97 9 post post JJ cord-011310-fm578rm5 97 10 - - JJ cord-011310-fm578rm5 97 11 H. h. JJ cord-011310-fm578rm5 97 12 pylori pylori NN cord-011310-fm578rm5 97 13 eradication eradication NN cord-011310-fm578rm5 97 14 with with IN cord-011310-fm578rm5 97 15 no no DT cord-011310-fm578rm5 97 16 significant significant JJ cord-011310-fm578rm5 97 17 differences difference NNS cord-011310-fm578rm5 97 18 in in IN cord-011310-fm578rm5 97 19 richness richness NN cord-011310-fm578rm5 97 20 and and CC cord-011310-fm578rm5 97 21 evenness evenness NN cord-011310-fm578rm5 97 22 of of IN cord-011310-fm578rm5 97 23 bacterial bacterial JJ cord-011310-fm578rm5 97 24 species specie NNS cord-011310-fm578rm5 97 25 , , , cord-011310-fm578rm5 97 26 changes change NNS cord-011310-fm578rm5 97 27 in in IN cord-011310-fm578rm5 97 28 the the DT cord-011310-fm578rm5 97 29 bacterial bacterial JJ cord-011310-fm578rm5 97 30 communities community NNS cord-011310-fm578rm5 97 31 at at IN cord-011310-fm578rm5 97 32 the the DT cord-011310-fm578rm5 97 33 phylum phylum NN cord-011310-fm578rm5 97 34 and and CC cord-011310-fm578rm5 97 35 genus genus NN cord-011310-fm578rm5 97 36 levels level NNS cord-011310-fm578rm5 97 37 were be VBD cord-011310-fm578rm5 97 38 noted note VBN cord-011310-fm578rm5 97 39 , , , cord-011310-fm578rm5 97 40 e.g. e.g. RB cord-011310-fm578rm5 97 41 , , , cord-011310-fm578rm5 97 42 the the DT cord-011310-fm578rm5 97 43 relative relative JJ cord-011310-fm578rm5 97 44 abundance abundance NN cord-011310-fm578rm5 97 45 of of IN cord-011310-fm578rm5 97 46 Bacterioidetes Bacterioidetes NNPS cord-011310-fm578rm5 97 47 decreased decrease VBD cord-011310-fm578rm5 97 48 and and CC cord-011310-fm578rm5 97 49 Firmicutes Firmicutes NNPS cord-011310-fm578rm5 97 50 increased increase VBD cord-011310-fm578rm5 97 51 . . . cord-011310-fm578rm5 98 1 An an DT cord-011310-fm578rm5 98 2 important important JJ cord-011310-fm578rm5 98 3 study study NN cord-011310-fm578rm5 98 4 primarily primarily RB cord-011310-fm578rm5 98 5 addressing address VBG cord-011310-fm578rm5 98 6 metabolic metabolic JJ cord-011310-fm578rm5 98 7 effects effect NNS cord-011310-fm578rm5 98 8 of of IN cord-011310-fm578rm5 98 9 H. h. NN cord-011310-fm578rm5 98 10 pylori pylori NN cord-011310-fm578rm5 98 11 eradication eradication NN cord-011310-fm578rm5 98 12 in in IN cord-011310-fm578rm5 98 13 general general JJ cord-011310-fm578rm5 98 14 population population NN cord-011310-fm578rm5 98 15 in in IN cord-011310-fm578rm5 98 16 Taiwan Taiwan NNP cord-011310-fm578rm5 98 17 was be VBD cord-011310-fm578rm5 98 18 recently recently RB cord-011310-fm578rm5 98 19 published publish VBN cord-011310-fm578rm5 98 20 [ [ -LRB- cord-011310-fm578rm5 98 21 47 47 CD cord-011310-fm578rm5 98 22 ] ] -RRB- cord-011310-fm578rm5 98 23 . . . cord-011310-fm578rm5 99 1 Significant significant JJ cord-011310-fm578rm5 99 2 perturbation perturbation NN cord-011310-fm578rm5 99 3 of of IN cord-011310-fm578rm5 99 4 gut gut NN cord-011310-fm578rm5 99 5 microbiota microbiota NN cord-011310-fm578rm5 99 6 in in IN cord-011310-fm578rm5 99 7 short short JJ cord-011310-fm578rm5 99 8 - - HYPH cord-011310-fm578rm5 99 9 term term NN cord-011310-fm578rm5 99 10 was be VBD cord-011310-fm578rm5 99 11 revealed reveal VBN cord-011310-fm578rm5 99 12 , , , cord-011310-fm578rm5 99 13 and and CC cord-011310-fm578rm5 99 14 it -PRON- PRP cord-011310-fm578rm5 99 15 was be VBD cord-011310-fm578rm5 99 16 significantly significantly RB cord-011310-fm578rm5 99 17 greater great JJR cord-011310-fm578rm5 99 18 for for IN cord-011310-fm578rm5 99 19 concomitant concomitant JJ cord-011310-fm578rm5 99 20 and and CC cord-011310-fm578rm5 99 21 bismuth bismuth JJ cord-011310-fm578rm5 99 22 quadruple quadruple JJ cord-011310-fm578rm5 99 23 therapies therapy NNS cord-011310-fm578rm5 99 24 than than IN cord-011310-fm578rm5 99 25 for for IN cord-011310-fm578rm5 99 26 a a DT cord-011310-fm578rm5 99 27 standard standard JJ cord-011310-fm578rm5 99 28 triple triple NN cord-011310-fm578rm5 99 29 . . . cord-011310-fm578rm5 100 1 Bismuth bismuth JJ cord-011310-fm578rm5 100 2 quadruple quadruple JJ cord-011310-fm578rm5 100 3 therapy therapy NN cord-011310-fm578rm5 100 4 , , , cord-011310-fm578rm5 100 5 on on IN cord-011310-fm578rm5 100 6 the the DT cord-011310-fm578rm5 100 7 other other JJ cord-011310-fm578rm5 100 8 hand hand NN cord-011310-fm578rm5 100 9 , , , cord-011310-fm578rm5 100 10 was be VBD cord-011310-fm578rm5 100 11 not not RB cord-011310-fm578rm5 100 12 associated associate VBN cord-011310-fm578rm5 100 13 with with IN cord-011310-fm578rm5 100 14 an an DT cord-011310-fm578rm5 100 15 increase increase NN cord-011310-fm578rm5 100 16 in in IN cord-011310-fm578rm5 100 17 resistance resistance NN cord-011310-fm578rm5 100 18 in in IN cord-011310-fm578rm5 100 19 E. E. NNP cord-011310-fm578rm5 100 20 coli coli NNS cord-011310-fm578rm5 100 21 . . . cord-011310-fm578rm5 101 1 The the DT cord-011310-fm578rm5 101 2 authors author NNS cord-011310-fm578rm5 101 3 also also RB cord-011310-fm578rm5 101 4 demonstrated demonstrate VBD cord-011310-fm578rm5 101 5 that that IN cord-011310-fm578rm5 101 6 for for IN cord-011310-fm578rm5 101 7 other other JJ cord-011310-fm578rm5 101 8 therapies therapy NNS cord-011310-fm578rm5 101 9 the the DT cord-011310-fm578rm5 101 10 resistance resistance NN cord-011310-fm578rm5 101 11 rates rate NNS cord-011310-fm578rm5 101 12 of of IN cord-011310-fm578rm5 101 13 E. E. NNP cord-011310-fm578rm5 101 14 coli coli NNS cord-011310-fm578rm5 101 15 and and CC cord-011310-fm578rm5 101 16 K. K. NNP cord-011310-fm578rm5 101 17 pneumoniae pneumoniae NNS cord-011310-fm578rm5 101 18 to to IN cord-011310-fm578rm5 101 19 certain certain JJ cord-011310-fm578rm5 101 20 antibiotics antibiotic NNS cord-011310-fm578rm5 101 21 were be VBD cord-011310-fm578rm5 101 22 restored restore VBN cord-011310-fm578rm5 101 23 at at IN cord-011310-fm578rm5 101 24 week week NN cord-011310-fm578rm5 101 25 8 8 CD cord-011310-fm578rm5 101 26 and and CC cord-011310-fm578rm5 101 27 1 1 CD cord-011310-fm578rm5 101 28 year year NN cord-011310-fm578rm5 101 29 after after IN cord-011310-fm578rm5 101 30 therapy therapy NN cord-011310-fm578rm5 101 31 [ [ -LRB- cord-011310-fm578rm5 101 32 47 47 CD cord-011310-fm578rm5 101 33 ] ] -RRB- cord-011310-fm578rm5 101 34 . . . cord-011310-fm578rm5 102 1 However however RB cord-011310-fm578rm5 102 2 , , , cord-011310-fm578rm5 102 3 this this DT cord-011310-fm578rm5 102 4 study study NN cord-011310-fm578rm5 102 5 focussed focusse VBD cord-011310-fm578rm5 102 6 only only RB cord-011310-fm578rm5 102 7 on on IN cord-011310-fm578rm5 102 8 gut gut NN cord-011310-fm578rm5 102 9 microbiome microbiome NN cord-011310-fm578rm5 102 10 and and CC cord-011310-fm578rm5 102 11 effect effect NN cord-011310-fm578rm5 102 12 on on IN cord-011310-fm578rm5 102 13 resistance resistance NN cord-011310-fm578rm5 102 14 rates rate NNS cord-011310-fm578rm5 102 15 in in IN cord-011310-fm578rm5 102 16 Gram gram NN cord-011310-fm578rm5 102 17 - - HYPH cord-011310-fm578rm5 102 18 negative negative JJ cord-011310-fm578rm5 102 19 bacteria bacteria NNS cord-011310-fm578rm5 102 20 . . . cord-011310-fm578rm5 103 1 Widespread widespread JJ cord-011310-fm578rm5 103 2 use use NN cord-011310-fm578rm5 103 3 of of IN cord-011310-fm578rm5 103 4 amoxicillin amoxicillin NNP cord-011310-fm578rm5 103 5 and and CC cord-011310-fm578rm5 103 6 clarithromycin clarithromycin NNP cord-011310-fm578rm5 103 7 causes cause VBZ cord-011310-fm578rm5 103 8 concern concern NN cord-011310-fm578rm5 103 9 about about IN cord-011310-fm578rm5 103 10 resistance resistance NN cord-011310-fm578rm5 103 11 rates rate NNS cord-011310-fm578rm5 103 12 in in IN cord-011310-fm578rm5 103 13 Gram gram NN cord-011310-fm578rm5 103 14 - - HYPH cord-011310-fm578rm5 103 15 positive positive JJ cord-011310-fm578rm5 103 16 bacteria bacteria NNS cord-011310-fm578rm5 103 17 such such JJ cord-011310-fm578rm5 103 18 as as IN cord-011310-fm578rm5 103 19 Str Str NNP cord-011310-fm578rm5 103 20 . . . cord-011310-fm578rm5 104 1 pneumoniae pneumoniae NN cord-011310-fm578rm5 104 2 and and CC cord-011310-fm578rm5 104 3 S. S. NNP cord-011310-fm578rm5 104 4 aureus aureus NN cord-011310-fm578rm5 104 5 [ [ -LRB- cord-011310-fm578rm5 104 6 48 48 CD cord-011310-fm578rm5 104 7 , , , cord-011310-fm578rm5 104 8 49 49 CD cord-011310-fm578rm5 104 9 ] ] -RRB- cord-011310-fm578rm5 104 10 . . . cord-011310-fm578rm5 105 1 Current current JJ cord-011310-fm578rm5 105 2 evolution evolution NN cord-011310-fm578rm5 105 3 of of IN cord-011310-fm578rm5 105 4 sequencing sequencing NN cord-011310-fm578rm5 105 5 methods method NNS cord-011310-fm578rm5 105 6 will will MD cord-011310-fm578rm5 105 7 provide provide VB cord-011310-fm578rm5 105 8 significant significant JJ cord-011310-fm578rm5 105 9 evidence evidence NN cord-011310-fm578rm5 105 10 related relate VBN cord-011310-fm578rm5 105 11 to to IN cord-011310-fm578rm5 105 12 the the DT cord-011310-fm578rm5 105 13 potential potential JJ cord-011310-fm578rm5 105 14 perturbation perturbation NN cord-011310-fm578rm5 105 15 of of IN cord-011310-fm578rm5 105 16 microbiota microbiota NN cord-011310-fm578rm5 105 17 following follow VBG cord-011310-fm578rm5 105 18 antibiotic antibiotic JJ cord-011310-fm578rm5 105 19 treatment treatment NN cord-011310-fm578rm5 105 20 , , , cord-011310-fm578rm5 105 21 including include VBG cord-011310-fm578rm5 105 22 H. h. NN cord-011310-fm578rm5 105 23 pylori pylori NN cord-011310-fm578rm5 105 24 eradication eradication NN cord-011310-fm578rm5 105 25 . . . cord-011310-fm578rm5 106 1 Several several JJ cord-011310-fm578rm5 106 2 studies study NNS cord-011310-fm578rm5 106 3 comparing compare VBG cord-011310-fm578rm5 106 4 the the DT cord-011310-fm578rm5 106 5 effect effect NN cord-011310-fm578rm5 106 6 of of IN cord-011310-fm578rm5 106 7 different different JJ cord-011310-fm578rm5 106 8 H. h. NN cord-011310-fm578rm5 106 9 pylori pylori NN cord-011310-fm578rm5 106 10 eradication eradication NN cord-011310-fm578rm5 106 11 regimens regimen NNS cord-011310-fm578rm5 106 12 on on IN cord-011310-fm578rm5 106 13 the the DT cord-011310-fm578rm5 106 14 gut gut NN cord-011310-fm578rm5 106 15 microbiome microbiome NN cord-011310-fm578rm5 106 16 or or CC cord-011310-fm578rm5 106 17 resistome resistome NNP cord-011310-fm578rm5 106 18 are be VBP cord-011310-fm578rm5 106 19 in in IN cord-011310-fm578rm5 106 20 progress progress NN cord-011310-fm578rm5 106 21 in in IN cord-011310-fm578rm5 106 22 different different JJ cord-011310-fm578rm5 106 23 countries country NNS cord-011310-fm578rm5 106 24 , , , cord-011310-fm578rm5 106 25 including include VBG cord-011310-fm578rm5 106 26 Taiwan Taiwan NNP cord-011310-fm578rm5 106 27 , , , cord-011310-fm578rm5 106 28 Spain Spain NNP cord-011310-fm578rm5 106 29 and and CC cord-011310-fm578rm5 106 30 Latvia Latvia NNP cord-011310-fm578rm5 106 31 . . . cord-011310-fm578rm5 107 1 In in IN cord-011310-fm578rm5 107 2 most most JJS cord-011310-fm578rm5 107 3 of of IN cord-011310-fm578rm5 107 4 them -PRON- PRP cord-011310-fm578rm5 107 5 , , , cord-011310-fm578rm5 107 6 the the DT cord-011310-fm578rm5 107 7 diversity diversity NN cord-011310-fm578rm5 107 8 of of IN cord-011310-fm578rm5 107 9 microbiota microbiota NN cord-011310-fm578rm5 107 10 is be VBZ cord-011310-fm578rm5 107 11 addressed address VBN cord-011310-fm578rm5 107 12 by by IN cord-011310-fm578rm5 107 13 means mean NNS cord-011310-fm578rm5 107 14 of of IN cord-011310-fm578rm5 107 15 16S 16S NNP cord-011310-fm578rm5 107 16 rRNA rrna NN cord-011310-fm578rm5 107 17 gene gene NN cord-011310-fm578rm5 107 18 sequencing sequencing NN cord-011310-fm578rm5 107 19 , , , cord-011310-fm578rm5 107 20 whereas whereas IN cord-011310-fm578rm5 107 21 others other NNS cord-011310-fm578rm5 107 22 apply apply VBP cord-011310-fm578rm5 107 23 metagenome metagenome NN cord-011310-fm578rm5 107 24 sequencing sequencing NN cord-011310-fm578rm5 107 25 . . . cord-011310-fm578rm5 108 1 The the DT cord-011310-fm578rm5 108 2 use use NN cord-011310-fm578rm5 108 3 of of IN cord-011310-fm578rm5 108 4 antibiotics antibiotic NNS cord-011310-fm578rm5 108 5 is be VBZ cord-011310-fm578rm5 108 6 the the DT cord-011310-fm578rm5 108 7 primary primary JJ cord-011310-fm578rm5 108 8 driver driver NN cord-011310-fm578rm5 108 9 for for IN cord-011310-fm578rm5 108 10 the the DT cord-011310-fm578rm5 108 11 development development NN cord-011310-fm578rm5 108 12 of of IN cord-011310-fm578rm5 108 13 resistance resistance NN cord-011310-fm578rm5 108 14 and and CC cord-011310-fm578rm5 108 15 also also RB cord-011310-fm578rm5 108 16 leads lead VBZ cord-011310-fm578rm5 108 17 to to IN cord-011310-fm578rm5 108 18 other other JJ cord-011310-fm578rm5 108 19 adverse adverse JJ cord-011310-fm578rm5 108 20 effects effect NNS cord-011310-fm578rm5 108 21 ranging range VBG cord-011310-fm578rm5 108 22 from from IN cord-011310-fm578rm5 108 23 allergic allergic JJ cord-011310-fm578rm5 108 24 reactions reaction NNS cord-011310-fm578rm5 108 25 to to IN cord-011310-fm578rm5 108 26 CDI CDI NNP cord-011310-fm578rm5 108 27 [ [ -LRB- cord-011310-fm578rm5 108 28 50 50 CD cord-011310-fm578rm5 108 29 ] ] -RRB- cord-011310-fm578rm5 108 30 . . . cord-011310-fm578rm5 109 1 The the DT cord-011310-fm578rm5 109 2 term term NN cord-011310-fm578rm5 109 3 " " `` cord-011310-fm578rm5 109 4 antimicrobial antimicrobial JJ cord-011310-fm578rm5 109 5 stewardship stewardship NN cord-011310-fm578rm5 109 6 " " '' cord-011310-fm578rm5 109 7 is be VBZ cord-011310-fm578rm5 109 8 encountered encounter VBN cord-011310-fm578rm5 109 9 in in IN cord-011310-fm578rm5 109 10 a a DT cord-011310-fm578rm5 109 11 growing grow VBG cord-011310-fm578rm5 109 12 number number NN cord-011310-fm578rm5 109 13 and and CC cord-011310-fm578rm5 109 14 increasingly increasingly RB cord-011310-fm578rm5 109 15 diverse diverse JJ cord-011310-fm578rm5 109 16 range range NN cord-011310-fm578rm5 109 17 of of IN cord-011310-fm578rm5 109 18 contexts context NNS cord-011310-fm578rm5 109 19 , , , cord-011310-fm578rm5 109 20 from from IN cord-011310-fm578rm5 109 21 antimicrobial antimicrobial JJ cord-011310-fm578rm5 109 22 stewardship stewardship NN cord-011310-fm578rm5 109 23 programmes programme NNS cord-011310-fm578rm5 109 24 in in IN cord-011310-fm578rm5 109 25 hospitals hospital NNS cord-011310-fm578rm5 109 26 and and CC cord-011310-fm578rm5 109 27 the the DT cord-011310-fm578rm5 109 28 community community NN cord-011310-fm578rm5 109 29 [ [ -LRB- cord-011310-fm578rm5 109 30 51 51 CD cord-011310-fm578rm5 109 31 ] ] -RRB- cord-011310-fm578rm5 109 32 , , , cord-011310-fm578rm5 109 33 to to IN cord-011310-fm578rm5 109 34 veterinary veterinary JJ cord-011310-fm578rm5 109 35 antimicrobial antimicrobial JJ cord-011310-fm578rm5 109 36 stewardship stewardship NN cord-011310-fm578rm5 109 37 [ [ -LRB- cord-011310-fm578rm5 109 38 52 52 CD cord-011310-fm578rm5 109 39 ] ] -RRB- cord-011310-fm578rm5 109 40 , , , cord-011310-fm578rm5 109 41 One one CD cord-011310-fm578rm5 109 42 Health Health NNP cord-011310-fm578rm5 109 43 antimicrobial antimicrobial JJ cord-011310-fm578rm5 109 44 stewardship stewardship NN cord-011310-fm578rm5 109 45 [ [ -LRB- cord-011310-fm578rm5 109 46 53 53 CD cord-011310-fm578rm5 109 47 ] ] -RRB- cord-011310-fm578rm5 109 48 and and CC cord-011310-fm578rm5 109 49 the the DT cord-011310-fm578rm5 109 50 WHO WHO NNP cord-011310-fm578rm5 109 51 global global JJ cord-011310-fm578rm5 109 52 stewardship stewardship NN cord-011310-fm578rm5 109 53 framework framework NN cord-011310-fm578rm5 109 54 [ [ -LRB- cord-011310-fm578rm5 109 55 54 54 CD cord-011310-fm578rm5 109 56 ] ] -RRB- cord-011310-fm578rm5 109 57 . . . cord-011310-fm578rm5 110 1 Because because IN cord-011310-fm578rm5 110 2 of of IN cord-011310-fm578rm5 110 3 the the DT cord-011310-fm578rm5 110 4 rapidly rapidly RB cord-011310-fm578rm5 110 5 increasing increase VBG cord-011310-fm578rm5 110 6 use use NN cord-011310-fm578rm5 110 7 of of IN cord-011310-fm578rm5 110 8 the the DT cord-011310-fm578rm5 110 9 term term NN cord-011310-fm578rm5 110 10 without without IN cord-011310-fm578rm5 110 11 a a DT cord-011310-fm578rm5 110 12 sole sole JJ cord-011310-fm578rm5 110 13 clear clear JJ cord-011310-fm578rm5 110 14 definition definition NN cord-011310-fm578rm5 110 15 , , , cord-011310-fm578rm5 110 16 it -PRON- PRP cord-011310-fm578rm5 110 17 has have VBZ cord-011310-fm578rm5 110 18 evolved evolve VBN cord-011310-fm578rm5 110 19 differently differently RB cord-011310-fm578rm5 110 20 in in IN cord-011310-fm578rm5 110 21 different different JJ cord-011310-fm578rm5 110 22 settings setting NNS cord-011310-fm578rm5 110 23 , , , cord-011310-fm578rm5 110 24 influenced influence VBN cord-011310-fm578rm5 110 25 by by IN cord-011310-fm578rm5 110 26 local local JJ cord-011310-fm578rm5 110 27 interpretations interpretation NNS cord-011310-fm578rm5 110 28 [ [ -LRB- cord-011310-fm578rm5 110 29 55 55 CD cord-011310-fm578rm5 110 30 ] ] -RRB- cord-011310-fm578rm5 110 31 . . . cord-011310-fm578rm5 111 1 In in IN cord-011310-fm578rm5 111 2 general general JJ cord-011310-fm578rm5 111 3 , , , cord-011310-fm578rm5 111 4 antimicrobial antimicrobial JJ cord-011310-fm578rm5 111 5 stewardship stewardship NN cord-011310-fm578rm5 111 6 programs program NNS cord-011310-fm578rm5 111 7 have have VBP cord-011310-fm578rm5 111 8 a a DT cord-011310-fm578rm5 111 9 direct direct JJ cord-011310-fm578rm5 111 10 responsibility responsibility NN cord-011310-fm578rm5 111 11 to to TO cord-011310-fm578rm5 111 12 ensure ensure VB cord-011310-fm578rm5 111 13 prudent prudent JJ cord-011310-fm578rm5 111 14 antibiotic antibiotic JJ cord-011310-fm578rm5 111 15 prescribing prescribing NN cord-011310-fm578rm5 111 16 . . . cord-011310-fm578rm5 112 1 Reducing reduce VBG cord-011310-fm578rm5 112 2 antibiotic antibiotic JJ cord-011310-fm578rm5 112 3 exposure exposure NN cord-011310-fm578rm5 112 4 should should MD cord-011310-fm578rm5 112 5 minimize minimize VB cord-011310-fm578rm5 112 6 the the DT cord-011310-fm578rm5 112 7 duration duration NN cord-011310-fm578rm5 112 8 and and CC cord-011310-fm578rm5 112 9 extent extent NN cord-011310-fm578rm5 112 10 of of IN cord-011310-fm578rm5 112 11 disruption disruption NN cord-011310-fm578rm5 112 12 of of IN cord-011310-fm578rm5 112 13 the the DT cord-011310-fm578rm5 112 14 microbiome microbiome NN cord-011310-fm578rm5 112 15 , , , cord-011310-fm578rm5 112 16 thereby thereby RB cord-011310-fm578rm5 112 17 reducing reduce VBG cord-011310-fm578rm5 112 18 collateral collateral JJ cord-011310-fm578rm5 112 19 damage damage NN cord-011310-fm578rm5 112 20 and and CC cord-011310-fm578rm5 112 21 improving improve VBG cord-011310-fm578rm5 112 22 patient patient JJ cord-011310-fm578rm5 112 23 outcomes outcome NNS cord-011310-fm578rm5 112 24 . . . cord-011310-fm578rm5 113 1 Prolonged prolonged JJ cord-011310-fm578rm5 113 2 courses course NNS cord-011310-fm578rm5 113 3 of of IN cord-011310-fm578rm5 113 4 antibiotics antibiotic NNS cord-011310-fm578rm5 113 5 also also RB cord-011310-fm578rm5 113 6 increase increase VBP cord-011310-fm578rm5 113 7 the the DT cord-011310-fm578rm5 113 8 risk risk NN cord-011310-fm578rm5 113 9 of of IN cord-011310-fm578rm5 113 10 colonization colonization NN cord-011310-fm578rm5 113 11 with with IN cord-011310-fm578rm5 113 12 multidrug multidrug NN cord-011310-fm578rm5 113 13 resistant resistant JJ cord-011310-fm578rm5 113 14 organisms organism NNS cord-011310-fm578rm5 113 15 . . . cord-011310-fm578rm5 114 1 Therefore therefore RB cord-011310-fm578rm5 114 2 , , , cord-011310-fm578rm5 114 3 the the DT cord-011310-fm578rm5 114 4 chain chain NN cord-011310-fm578rm5 114 5 of of IN cord-011310-fm578rm5 114 6 transmission transmission NN cord-011310-fm578rm5 114 7 increases increase VBZ cord-011310-fm578rm5 114 8 the the DT cord-011310-fm578rm5 114 9 risk risk NN cord-011310-fm578rm5 114 10 of of IN cord-011310-fm578rm5 114 11 horizontally horizontally RB cord-011310-fm578rm5 114 12 infecting infect VBG cord-011310-fm578rm5 114 13 more more JJR cord-011310-fm578rm5 114 14 than than IN cord-011310-fm578rm5 114 15 one one CD cord-011310-fm578rm5 114 16 patient patient NN cord-011310-fm578rm5 114 17 . . . cord-011310-fm578rm5 115 1 Interrupting interrupt VBG cord-011310-fm578rm5 115 2 this this DT cord-011310-fm578rm5 115 3 chain chain NN cord-011310-fm578rm5 115 4 is be VBZ cord-011310-fm578rm5 115 5 as as RB cord-011310-fm578rm5 115 6 important important JJ cord-011310-fm578rm5 115 7 as as IN cord-011310-fm578rm5 115 8 preventing prevent VBG cord-011310-fm578rm5 115 9 the the DT cord-011310-fm578rm5 115 10 development development NN cord-011310-fm578rm5 115 11 of of IN cord-011310-fm578rm5 115 12 resistance resistance NN cord-011310-fm578rm5 115 13 . . . cord-011310-fm578rm5 116 1 Data datum NNS cord-011310-fm578rm5 116 2 from from IN cord-011310-fm578rm5 116 3 developed develop VBN cord-011310-fm578rm5 116 4 nations nation NNS cord-011310-fm578rm5 116 5 suggest suggest VBP cord-011310-fm578rm5 116 6 that that IN cord-011310-fm578rm5 116 7 80 80 CD cord-011310-fm578rm5 116 8 % % NN cord-011310-fm578rm5 116 9 or or CC cord-011310-fm578rm5 116 10 more more JJR cord-011310-fm578rm5 116 11 of of IN cord-011310-fm578rm5 116 12 antibiotic antibiotic JJ cord-011310-fm578rm5 116 13 prescriptions prescription NNS cord-011310-fm578rm5 116 14 are be VBP cord-011310-fm578rm5 116 15 for for IN cord-011310-fm578rm5 116 16 outpatients outpatient NNS cord-011310-fm578rm5 116 17 [ [ -LRB- cord-011310-fm578rm5 116 18 56 56 CD cord-011310-fm578rm5 116 19 ] ] -RRB- cord-011310-fm578rm5 116 20 . . . cord-011310-fm578rm5 117 1 Therefore therefore RB cord-011310-fm578rm5 117 2 , , , cord-011310-fm578rm5 117 3 limiting limit VBG cord-011310-fm578rm5 117 4 their -PRON- PRP$ cord-011310-fm578rm5 117 5 use use NN cord-011310-fm578rm5 117 6 of of IN cord-011310-fm578rm5 117 7 antibiotics antibiotic NNS cord-011310-fm578rm5 117 8 is be VBZ cord-011310-fm578rm5 117 9 essential essential JJ cord-011310-fm578rm5 117 10 in in IN cord-011310-fm578rm5 117 11 reducing reduce VBG cord-011310-fm578rm5 117 12 both both CC cord-011310-fm578rm5 117 13 resistance resistance NN cord-011310-fm578rm5 117 14 and and CC cord-011310-fm578rm5 117 15 adverse adverse JJ cord-011310-fm578rm5 117 16 events event NNS cord-011310-fm578rm5 117 17 . . . cord-011310-fm578rm5 118 1 Over over IN cord-011310-fm578rm5 118 2 the the DT cord-011310-fm578rm5 118 3 last last JJ cord-011310-fm578rm5 118 4 20 20 CD cord-011310-fm578rm5 118 5 years year NNS cord-011310-fm578rm5 118 6 , , , cord-011310-fm578rm5 118 7 several several JJ cord-011310-fm578rm5 118 8 developed develop VBN cord-011310-fm578rm5 118 9 countries country NNS cord-011310-fm578rm5 118 10 introduced introduce VBD cord-011310-fm578rm5 118 11 nationwide nationwide JJ cord-011310-fm578rm5 118 12 initiatives initiative NNS cord-011310-fm578rm5 118 13 aimed aim VBN cord-011310-fm578rm5 118 14 at at IN cord-011310-fm578rm5 118 15 reduced reduce VBN cord-011310-fm578rm5 118 16 antibiotic antibiotic JJ cord-011310-fm578rm5 118 17 consumption consumption NN cord-011310-fm578rm5 118 18 , , , cord-011310-fm578rm5 118 19 achieved achieve VBD cord-011310-fm578rm5 118 20 a a DT cord-011310-fm578rm5 118 21 drop drop NN cord-011310-fm578rm5 118 22 of of IN cord-011310-fm578rm5 118 23 > > SYM cord-011310-fm578rm5 118 24 30 30 CD cord-011310-fm578rm5 118 25 % % NN cord-011310-fm578rm5 118 26 . . . cord-011310-fm578rm5 119 1 In in IN cord-011310-fm578rm5 119 2 Sweden Sweden NNP cord-011310-fm578rm5 119 3 between between IN cord-011310-fm578rm5 119 4 1992 1992 CD cord-011310-fm578rm5 119 5 and and CC cord-011310-fm578rm5 119 6 2016 2016 CD cord-011310-fm578rm5 119 7 , , , cord-011310-fm578rm5 119 8 the the DT cord-011310-fm578rm5 119 9 number number NN cord-011310-fm578rm5 119 10 of of IN cord-011310-fm578rm5 119 11 prescriptions prescription NNS cord-011310-fm578rm5 119 12 per per IN cord-011310-fm578rm5 119 13 1000 1000 CD cord-011310-fm578rm5 119 14 inhabitants inhabitant NNS cord-011310-fm578rm5 119 15 per per IN cord-011310-fm578rm5 119 16 year year NN cord-011310-fm578rm5 119 17 in in IN cord-011310-fm578rm5 119 18 outpatient outpatient NN cord-011310-fm578rm5 119 19 care care NN cord-011310-fm578rm5 119 20 , , , cord-011310-fm578rm5 119 21 including include VBG cord-011310-fm578rm5 119 22 primary primary JJ cord-011310-fm578rm5 119 23 health health NN cord-011310-fm578rm5 119 24 care care NN cord-011310-fm578rm5 119 25 , , , cord-011310-fm578rm5 119 26 decreased decrease VBD cord-011310-fm578rm5 119 27 by by IN cord-011310-fm578rm5 119 28 43 43 CD cord-011310-fm578rm5 119 29 % % NN cord-011310-fm578rm5 119 30 from from IN cord-011310-fm578rm5 119 31 560 560 CD cord-011310-fm578rm5 119 32 to to IN cord-011310-fm578rm5 119 33 318 318 CD cord-011310-fm578rm5 119 34 , , , cord-011310-fm578rm5 119 35 whereas whereas IN cord-011310-fm578rm5 119 36 among among IN cord-011310-fm578rm5 119 37 children child NNS cord-011310-fm578rm5 119 38 aged age VBN cord-011310-fm578rm5 119 39 0 0 CD cord-011310-fm578rm5 119 40 - - SYM cord-011310-fm578rm5 119 41 4 4 CD cord-011310-fm578rm5 119 42 years year NNS cord-011310-fm578rm5 119 43 it -PRON- PRP cord-011310-fm578rm5 119 44 decreased decrease VBD cord-011310-fm578rm5 119 45 by by IN cord-011310-fm578rm5 119 46 73 73 CD cord-011310-fm578rm5 119 47 % % NN cord-011310-fm578rm5 119 48 from from IN cord-011310-fm578rm5 119 49 1328 1328 CD cord-011310-fm578rm5 119 50 to to IN cord-011310-fm578rm5 119 51 349 349 CD cord-011310-fm578rm5 119 52 [ [ -LRB- cord-011310-fm578rm5 119 53 57 57 CD cord-011310-fm578rm5 119 54 ] ] -RRB- cord-011310-fm578rm5 119 55 . . . cord-011310-fm578rm5 120 1 Between between IN cord-011310-fm578rm5 120 2 2012 2012 CD cord-011310-fm578rm5 120 3 and and CC cord-011310-fm578rm5 120 4 2017 2017 CD cord-011310-fm578rm5 120 5 , , , cord-011310-fm578rm5 120 6 a a DT cord-011310-fm578rm5 120 7 statistically statistically RB cord-011310-fm578rm5 120 8 significant significant JJ cord-011310-fm578rm5 120 9 decreasing decrease VBG cord-011310-fm578rm5 120 10 trend trend NN cord-011310-fm578rm5 120 11 in in IN cord-011310-fm578rm5 120 12 antibiotic antibiotic JJ cord-011310-fm578rm5 120 13 use use NN cord-011310-fm578rm5 120 14 was be VBD cord-011310-fm578rm5 120 15 also also RB cord-011310-fm578rm5 120 16 seen see VBN cord-011310-fm578rm5 120 17 in in IN cord-011310-fm578rm5 120 18 Finland Finland NNP cord-011310-fm578rm5 120 19 , , , cord-011310-fm578rm5 120 20 Luxembourg Luxembourg NNP cord-011310-fm578rm5 120 21 and and CC cord-011310-fm578rm5 120 22 Norway Norway NNP cord-011310-fm578rm5 120 23 [ [ -LRB- cord-011310-fm578rm5 120 24 58 58 CD cord-011310-fm578rm5 120 25 ] ] -RRB- cord-011310-fm578rm5 120 26 . . . cord-011310-fm578rm5 121 1 In in IN cord-011310-fm578rm5 121 2 March March NNP cord-011310-fm578rm5 121 3 2015 2015 CD cord-011310-fm578rm5 121 4 , , , cord-011310-fm578rm5 121 5 the the DT cord-011310-fm578rm5 121 6 White White NNP cord-011310-fm578rm5 121 7 House House NNP cord-011310-fm578rm5 121 8 released release VBD cord-011310-fm578rm5 121 9 the the DT cord-011310-fm578rm5 121 10 National National NNP cord-011310-fm578rm5 121 11 Action Action NNP cord-011310-fm578rm5 121 12 Plan Plan NNP cord-011310-fm578rm5 121 13 for for IN cord-011310-fm578rm5 121 14 Combating combat VBG cord-011310-fm578rm5 121 15 Antibiotic Antibiotic NNP cord-011310-fm578rm5 121 16 - - HYPH cord-011310-fm578rm5 121 17 Resistant resistant JJ cord-011310-fm578rm5 121 18 Bacteria Bacteria NNS cord-011310-fm578rm5 121 19 , , , cord-011310-fm578rm5 121 20 which which WDT cord-011310-fm578rm5 121 21 set set VBD cord-011310-fm578rm5 121 22 a a DT cord-011310-fm578rm5 121 23 target target NN cord-011310-fm578rm5 121 24 of of IN cord-011310-fm578rm5 121 25 reducing reduce VBG cord-011310-fm578rm5 121 26 inappropriate inappropriate JJ cord-011310-fm578rm5 121 27 antibiotic antibiotic JJ cord-011310-fm578rm5 121 28 use use NN cord-011310-fm578rm5 121 29 in in IN cord-011310-fm578rm5 121 30 the the DT cord-011310-fm578rm5 121 31 outpatient outpatient NN cord-011310-fm578rm5 121 32 setting set VBG cord-011310-fm578rm5 121 33 by by IN cord-011310-fm578rm5 121 34 50 50 CD cord-011310-fm578rm5 121 35 % % NN cord-011310-fm578rm5 121 36 by by IN cord-011310-fm578rm5 121 37 2020 2020 CD cord-011310-fm578rm5 121 38 [ [ -LRB- cord-011310-fm578rm5 121 39 59 59 CD cord-011310-fm578rm5 121 40 ] ] -RRB- cord-011310-fm578rm5 121 41 . . . cord-011310-fm578rm5 122 1 In in IN cord-011310-fm578rm5 122 2 light light NN cord-011310-fm578rm5 122 3 of of IN cord-011310-fm578rm5 122 4 these these DT cord-011310-fm578rm5 122 5 trends trend NNS cord-011310-fm578rm5 122 6 , , , cord-011310-fm578rm5 122 7 any any DT cord-011310-fm578rm5 122 8 suggestion suggestion NN cord-011310-fm578rm5 122 9 for for IN cord-011310-fm578rm5 122 10 mass mass JJ cord-011310-fm578rm5 122 11 treatment treatment NN cord-011310-fm578rm5 122 12 of of IN cord-011310-fm578rm5 122 13 infections infection NNS cord-011310-fm578rm5 122 14 that that WDT cord-011310-fm578rm5 122 15 would would MD cord-011310-fm578rm5 122 16 lead lead VB cord-011310-fm578rm5 122 17 to to IN cord-011310-fm578rm5 122 18 an an DT cord-011310-fm578rm5 122 19 increase increase NN cord-011310-fm578rm5 122 20 in in IN cord-011310-fm578rm5 122 21 antibiotic antibiotic JJ cord-011310-fm578rm5 122 22 consumption consumption NN cord-011310-fm578rm5 122 23 will will MD cord-011310-fm578rm5 122 24 be be VB cord-011310-fm578rm5 122 25 carefully carefully RB cord-011310-fm578rm5 122 26 scrutinized scrutinize VBN cord-011310-fm578rm5 122 27 by by IN cord-011310-fm578rm5 122 28 national national JJ cord-011310-fm578rm5 122 29 authorities authority NNS cord-011310-fm578rm5 122 30 and and CC cord-011310-fm578rm5 122 31 experts expert NNS cord-011310-fm578rm5 122 32 . . . cord-011310-fm578rm5 123 1 Amoxicillin Amoxicillin NNP cord-011310-fm578rm5 123 2 and and CC cord-011310-fm578rm5 123 3 clarithromycin clarithromycin NNS cord-011310-fm578rm5 123 4 , , , cord-011310-fm578rm5 123 5 drugs drug NNS cord-011310-fm578rm5 123 6 of of IN cord-011310-fm578rm5 123 7 choice choice NN cord-011310-fm578rm5 123 8 for for IN cord-011310-fm578rm5 123 9 treatment treatment NN cord-011310-fm578rm5 123 10 of of IN cord-011310-fm578rm5 123 11 H. H. NNP cord-011310-fm578rm5 123 12 pylori pylori NN cord-011310-fm578rm5 123 13 infections infection NNS cord-011310-fm578rm5 123 14 suggested suggest VBN cord-011310-fm578rm5 123 15 by by IN cord-011310-fm578rm5 123 16 current current JJ cord-011310-fm578rm5 123 17 guidelines guideline NNS cord-011310-fm578rm5 123 18 , , , cord-011310-fm578rm5 123 19 have have VBP cord-011310-fm578rm5 123 20 wide wide JJ cord-011310-fm578rm5 123 21 application application NN cord-011310-fm578rm5 123 22 for for IN cord-011310-fm578rm5 123 23 the the DT cord-011310-fm578rm5 123 24 treatment treatment NN cord-011310-fm578rm5 123 25 of of IN cord-011310-fm578rm5 123 26 several several JJ cord-011310-fm578rm5 123 27 community community NN cord-011310-fm578rm5 123 28 - - HYPH cord-011310-fm578rm5 123 29 acquired acquire VBN cord-011310-fm578rm5 123 30 infections infection NNS cord-011310-fm578rm5 123 31 and and CC cord-011310-fm578rm5 123 32 account account VBP cord-011310-fm578rm5 123 33 for for IN cord-011310-fm578rm5 123 34 large large JJ cord-011310-fm578rm5 123 35 proportion proportion NN cord-011310-fm578rm5 123 36 of of IN cord-011310-fm578rm5 123 37 ambulatory ambulatory JJ cord-011310-fm578rm5 123 38 antibiotic antibiotic JJ cord-011310-fm578rm5 123 39 prescriptions prescription NNS cord-011310-fm578rm5 123 40 in in IN cord-011310-fm578rm5 123 41 many many JJ cord-011310-fm578rm5 123 42 countries country NNS cord-011310-fm578rm5 123 43 . . . cord-011310-fm578rm5 124 1 They -PRON- PRP cord-011310-fm578rm5 124 2 are be VBP cord-011310-fm578rm5 124 3 part part NN cord-011310-fm578rm5 124 4 of of IN cord-011310-fm578rm5 124 5 the the DT cord-011310-fm578rm5 124 6 suggested suggest VBN cord-011310-fm578rm5 124 7 first first JJ cord-011310-fm578rm5 124 8 or or CC cord-011310-fm578rm5 124 9 second second JJ cord-011310-fm578rm5 124 10 line line NN cord-011310-fm578rm5 124 11 treatment treatment NN cord-011310-fm578rm5 124 12 regimens regimen NNS cord-011310-fm578rm5 124 13 for for IN cord-011310-fm578rm5 124 14 community community NN cord-011310-fm578rm5 124 15 acquired acquire VBD cord-011310-fm578rm5 124 16 pneumonia pneumonia NN cord-011310-fm578rm5 124 17 [ [ -LRB- cord-011310-fm578rm5 124 18 60 60 CD cord-011310-fm578rm5 124 19 ] ] -RRB- cord-011310-fm578rm5 124 20 [ [ -LRB- cord-011310-fm578rm5 124 21 61 61 CD cord-011310-fm578rm5 124 22 ] ] -RRB- cord-011310-fm578rm5 124 23 [ [ -LRB- cord-011310-fm578rm5 124 24 62 62 CD cord-011310-fm578rm5 124 25 ] ] -RRB- cord-011310-fm578rm5 124 26 [ [ -LRB- cord-011310-fm578rm5 124 27 63 63 CD cord-011310-fm578rm5 124 28 ] ] -RRB- cord-011310-fm578rm5 124 29 . . . cord-011310-fm578rm5 125 1 Amoxicillin Amoxicillin NNP cord-011310-fm578rm5 125 2 or or CC cord-011310-fm578rm5 125 3 amoxicillin amoxicillin NNP cord-011310-fm578rm5 125 4 / / SYM cord-011310-fm578rm5 125 5 clavulanate clavulanate NNP cord-011310-fm578rm5 125 6 is be VBZ cord-011310-fm578rm5 125 7 often often RB cord-011310-fm578rm5 125 8 suggested suggest VBN cord-011310-fm578rm5 125 9 as as IN cord-011310-fm578rm5 125 10 first first JJ cord-011310-fm578rm5 125 11 - - HYPH cord-011310-fm578rm5 125 12 line line NN cord-011310-fm578rm5 125 13 treatment treatment NN cord-011310-fm578rm5 125 14 for for IN cord-011310-fm578rm5 125 15 otitis otitis NN cord-011310-fm578rm5 125 16 media medium NNS cord-011310-fm578rm5 125 17 , , , cord-011310-fm578rm5 125 18 bacterial bacterial JJ cord-011310-fm578rm5 125 19 rhinosinusitis rhinosinusitis NN cord-011310-fm578rm5 125 20 , , , cord-011310-fm578rm5 125 21 dental dental JJ cord-011310-fm578rm5 125 22 infection infection NN cord-011310-fm578rm5 125 23 and and CC cord-011310-fm578rm5 125 24 urinary urinary JJ cord-011310-fm578rm5 125 25 tract tract JJ cord-011310-fm578rm5 125 26 infections infection NNS cord-011310-fm578rm5 125 27 . . . cord-011310-fm578rm5 126 1 Macrolides macrolide NNS cord-011310-fm578rm5 126 2 are be VBP cord-011310-fm578rm5 126 3 often often RB cord-011310-fm578rm5 126 4 recommended recommend VBN cord-011310-fm578rm5 126 5 as as IN cord-011310-fm578rm5 126 6 replacement replacement NN cord-011310-fm578rm5 126 7 treatment treatment NN cord-011310-fm578rm5 126 8 for for IN cord-011310-fm578rm5 126 9 patients patient NNS cord-011310-fm578rm5 126 10 with with IN cord-011310-fm578rm5 126 11 penicillin penicillin NN cord-011310-fm578rm5 126 12 allergy allergy NN cord-011310-fm578rm5 126 13 . . . cord-011310-fm578rm5 127 1 Use Use NNP cord-011310-fm578rm5 127 2 of of IN cord-011310-fm578rm5 127 3 azithromycin azithromycin NNP cord-011310-fm578rm5 127 4 has have VBZ cord-011310-fm578rm5 127 5 been be VBN cord-011310-fm578rm5 127 6 suggested suggest VBN cord-011310-fm578rm5 127 7 for for IN cord-011310-fm578rm5 127 8 mass mass JJ cord-011310-fm578rm5 127 9 treatment treatment NN cord-011310-fm578rm5 127 10 for for IN cord-011310-fm578rm5 127 11 Chlamydia Chlamydia NNP cord-011310-fm578rm5 127 12 trachomatis trachomatis NN cord-011310-fm578rm5 127 13 eye eye NN cord-011310-fm578rm5 127 14 infections infection NNS cord-011310-fm578rm5 127 15 in in IN cord-011310-fm578rm5 127 16 developing develop VBG cord-011310-fm578rm5 127 17 countries country NNS cord-011310-fm578rm5 127 18 . . . cord-011310-fm578rm5 128 1 This this DT cord-011310-fm578rm5 128 2 has have VBZ cord-011310-fm578rm5 128 3 already already RB cord-011310-fm578rm5 128 4 provoked provoke VBN cord-011310-fm578rm5 128 5 significant significant JJ cord-011310-fm578rm5 128 6 concern concern NN cord-011310-fm578rm5 128 7 on on IN cord-011310-fm578rm5 128 8 its -PRON- PRP$ cord-011310-fm578rm5 128 9 potential potential JJ cord-011310-fm578rm5 128 10 adverse adverse JJ cord-011310-fm578rm5 128 11 events event NNS cord-011310-fm578rm5 128 12 , , , cord-011310-fm578rm5 128 13 even even RB cord-011310-fm578rm5 128 14 though though IN cord-011310-fm578rm5 128 15 the the DT cord-011310-fm578rm5 128 16 prevalence prevalence NN cord-011310-fm578rm5 128 17 of of IN cord-011310-fm578rm5 128 18 Chlamydia Chlamydia NNP cord-011310-fm578rm5 128 19 is be VBZ cord-011310-fm578rm5 128 20 significantly significantly RB cord-011310-fm578rm5 128 21 lower low JJR cord-011310-fm578rm5 128 22 than than IN cord-011310-fm578rm5 128 23 H. H. NNP cord-011310-fm578rm5 128 24 pylori pylori NN cord-011310-fm578rm5 128 25 . . . cord-011310-fm578rm5 129 1 Monitoring monitoring NN cord-011310-fm578rm5 129 2 of of IN cord-011310-fm578rm5 129 3 the the DT cord-011310-fm578rm5 129 4 resistance resistance NN cord-011310-fm578rm5 129 5 in in IN cord-011310-fm578rm5 129 6 multiple multiple JJ cord-011310-fm578rm5 129 7 organisms organism NNS cord-011310-fm578rm5 129 8 has have VBZ cord-011310-fm578rm5 129 9 been be VBN cord-011310-fm578rm5 129 10 suggested suggest VBN cord-011310-fm578rm5 129 11 on on IN cord-011310-fm578rm5 129 12 this this DT cord-011310-fm578rm5 129 13 indication indication NN cord-011310-fm578rm5 129 14 [ [ -LRB- cord-011310-fm578rm5 129 15 64 64 CD cord-011310-fm578rm5 129 16 ] ] -RRB- cord-011310-fm578rm5 129 17 . . . cord-011310-fm578rm5 130 1 We -PRON- PRP cord-011310-fm578rm5 130 2 conducted conduct VBD cord-011310-fm578rm5 130 3 an an DT cord-011310-fm578rm5 130 4 exercise exercise NN cord-011310-fm578rm5 130 5 by by IN cord-011310-fm578rm5 130 6 estimating estimate VBG cord-011310-fm578rm5 130 7 the the DT cord-011310-fm578rm5 130 8 expected expect VBN cord-011310-fm578rm5 130 9 increase increase NN cord-011310-fm578rm5 130 10 in in IN cord-011310-fm578rm5 130 11 clarithromycin clarithromycin NNS cord-011310-fm578rm5 130 12 and and CC cord-011310-fm578rm5 130 13 amoxicillin amoxicillin JJ cord-011310-fm578rm5 130 14 consumption consumption NN cord-011310-fm578rm5 130 15 in in IN cord-011310-fm578rm5 130 16 Latvia Latvia NNP cord-011310-fm578rm5 130 17 if if IN cord-011310-fm578rm5 130 18 an an DT cord-011310-fm578rm5 130 19 H. h. NN cord-011310-fm578rm5 130 20 pylori pylori NN cord-011310-fm578rm5 130 21 eradication eradication NN cord-011310-fm578rm5 130 22 program program NN cord-011310-fm578rm5 130 23 would would MD cord-011310-fm578rm5 130 24 be be VB cord-011310-fm578rm5 130 25 implemented implement VBN cord-011310-fm578rm5 130 26 . . . cord-011310-fm578rm5 131 1 Latvia Latvia NNP cord-011310-fm578rm5 131 2 is be VBZ cord-011310-fm578rm5 131 3 a a DT cord-011310-fm578rm5 131 4 small small JJ cord-011310-fm578rm5 131 5 country country NN cord-011310-fm578rm5 131 6 ( ( -LRB- cord-011310-fm578rm5 131 7 population population NN cord-011310-fm578rm5 131 8 ~ ~ NFP cord-011310-fm578rm5 131 9 two two CD cord-011310-fm578rm5 131 10 million million CD cord-011310-fm578rm5 131 11 ) ) -RRB- cord-011310-fm578rm5 131 12 in in IN cord-011310-fm578rm5 131 13 northern northern JJ cord-011310-fm578rm5 131 14 Europe Europe NNP cord-011310-fm578rm5 131 15 with with IN cord-011310-fm578rm5 131 16 a a DT cord-011310-fm578rm5 131 17 relatively relatively RB cord-011310-fm578rm5 131 18 low low JJ cord-011310-fm578rm5 131 19 consumption consumption NN cord-011310-fm578rm5 131 20 of of IN cord-011310-fm578rm5 131 21 antibiotics antibiotic NNS cord-011310-fm578rm5 131 22 and and CC cord-011310-fm578rm5 131 23 relatively relatively RB cord-011310-fm578rm5 131 24 high high JJ cord-011310-fm578rm5 131 25 incidence incidence NN cord-011310-fm578rm5 131 26 of of IN cord-011310-fm578rm5 131 27 gastric gastric JJ cord-011310-fm578rm5 131 28 cancerthe cancerthe NNP cord-011310-fm578rm5 131 29 incidence incidence NN cord-011310-fm578rm5 131 30 per per IN cord-011310-fm578rm5 131 31 100,000 100,000 CD cord-011310-fm578rm5 131 32 inhabitants inhabitant NNS cord-011310-fm578rm5 131 33 in in IN cord-011310-fm578rm5 131 34 both both DT cord-011310-fm578rm5 131 35 genders gender NNS cord-011310-fm578rm5 131 36 is be VBZ cord-011310-fm578rm5 131 37 12.9 12.9 CD cord-011310-fm578rm5 131 38 ( ( -LRB- cord-011310-fm578rm5 131 39 ASR ASR NNP cord-011310-fm578rm5 131 40 , , , cord-011310-fm578rm5 131 41 world world NN cord-011310-fm578rm5 131 42 population population NN cord-011310-fm578rm5 131 43 ) ) -RRB- cord-011310-fm578rm5 131 44 [ [ -LRB- cord-011310-fm578rm5 131 45 65 65 CD cord-011310-fm578rm5 131 46 ] ] -RRB- cord-011310-fm578rm5 131 47 . . . cord-011310-fm578rm5 132 1 We -PRON- PRP cord-011310-fm578rm5 132 2 used use VBD cord-011310-fm578rm5 132 3 data datum NNS cord-011310-fm578rm5 132 4 on on IN cord-011310-fm578rm5 132 5 the the DT cord-011310-fm578rm5 132 6 clarithromycin clarithromycin NNS cord-011310-fm578rm5 132 7 ( ( -LRB- cord-011310-fm578rm5 132 8 J01FA09 J01FA09 NNP cord-011310-fm578rm5 132 9 ) ) -RRB- cord-011310-fm578rm5 132 10 , , , cord-011310-fm578rm5 132 11 amoxicillin amoxicillin NNP cord-011310-fm578rm5 132 12 ( ( -LRB- cord-011310-fm578rm5 132 13 J01CR04 J01CR04 NNP cord-011310-fm578rm5 132 14 ) ) -RRB- cord-011310-fm578rm5 132 15 , , , cord-011310-fm578rm5 132 16 and and CC cord-011310-fm578rm5 133 1 amoxicillin amoxicillin NNP cord-011310-fm578rm5 133 2 beta beta NN cord-011310-fm578rm5 133 3 - - HYPH cord-011310-fm578rm5 133 4 lactam lactam NN cord-011310-fm578rm5 133 5 combination combination NN cord-011310-fm578rm5 133 6 ( ( -LRB- cord-011310-fm578rm5 133 7 J01CR02 J01CR02 NNP cord-011310-fm578rm5 133 8 ) ) -RRB- cord-011310-fm578rm5 133 9 consumption consumption NN cord-011310-fm578rm5 133 10 in in IN cord-011310-fm578rm5 133 11 the the DT cord-011310-fm578rm5 133 12 country country NN cord-011310-fm578rm5 133 13 provided provide VBN cord-011310-fm578rm5 133 14 by by IN cord-011310-fm578rm5 133 15 the the DT cord-011310-fm578rm5 133 16 State State NNP cord-011310-fm578rm5 133 17 Agency Agency NNP cord-011310-fm578rm5 133 18 of of IN cord-011310-fm578rm5 133 19 Medicines Medicines NNPS cord-011310-fm578rm5 133 20 and and CC cord-011310-fm578rm5 133 21 expressed express VBD cord-011310-fm578rm5 133 22 in in IN cord-011310-fm578rm5 133 23 defined define VBN cord-011310-fm578rm5 133 24 daily daily JJ cord-011310-fm578rm5 133 25 doses dose NNS cord-011310-fm578rm5 133 26 ( ( -LRB- cord-011310-fm578rm5 133 27 DDD DDD NNP cord-011310-fm578rm5 133 28 ) ) -RRB- cord-011310-fm578rm5 133 29 per per IN cord-011310-fm578rm5 133 30 1000 1000 CD cord-011310-fm578rm5 133 31 inhabitants inhabitant NNS cord-011310-fm578rm5 133 32 in in IN cord-011310-fm578rm5 133 33 Latvia Latvia NNP cord-011310-fm578rm5 133 34 within within IN cord-011310-fm578rm5 133 35 the the DT cord-011310-fm578rm5 133 36 period period NN cord-011310-fm578rm5 133 37 2014 2014 CD cord-011310-fm578rm5 133 38 - - SYM cord-011310-fm578rm5 133 39 2018 2018 CD cord-011310-fm578rm5 133 40 . . . cord-011310-fm578rm5 134 1 Mathematical mathematical JJ cord-011310-fm578rm5 134 2 projection projection NN cord-011310-fm578rm5 134 3 for for IN cord-011310-fm578rm5 134 4 the the DT cord-011310-fm578rm5 134 5 next next JJ cord-011310-fm578rm5 134 6 3 3 CD cord-011310-fm578rm5 134 7 years year NNS cord-011310-fm578rm5 134 8 was be VBD cord-011310-fm578rm5 134 9 made make VBN cord-011310-fm578rm5 134 10 , , , cord-011310-fm578rm5 134 11 and and CC cord-011310-fm578rm5 134 12 population population NN cord-011310-fm578rm5 134 13 distribution distribution NN cord-011310-fm578rm5 134 14 per per IN cord-011310-fm578rm5 134 15 relevant relevant JJ cord-011310-fm578rm5 134 16 age age NN cord-011310-fm578rm5 134 17 groups group NNS cord-011310-fm578rm5 134 18 from from IN cord-011310-fm578rm5 134 19 the the DT cord-011310-fm578rm5 134 20 official official JJ cord-011310-fm578rm5 134 21 statistics statistic NNS cord-011310-fm578rm5 134 22 was be VBD cord-011310-fm578rm5 134 23 used use VBN cord-011310-fm578rm5 134 24 . . . cord-011310-fm578rm5 135 1 According accord VBG cord-011310-fm578rm5 135 2 to to IN cord-011310-fm578rm5 135 3 the the DT cord-011310-fm578rm5 135 4 guidelines guideline NNS cord-011310-fm578rm5 135 5 [ [ -LRB- cord-011310-fm578rm5 135 6 11 11 CD cord-011310-fm578rm5 135 7 ] ] -RRB- cord-011310-fm578rm5 135 8 , , , cord-011310-fm578rm5 135 9 a a DT cord-011310-fm578rm5 135 10 14-day 14-day CD cord-011310-fm578rm5 135 11 eradication eradication NN cord-011310-fm578rm5 135 12 regimen regimen NN cord-011310-fm578rm5 135 13 with with IN cord-011310-fm578rm5 135 14 2 2 CD cord-011310-fm578rm5 135 15 g g NN cord-011310-fm578rm5 135 16 per per IN cord-011310-fm578rm5 135 17 day day NN cord-011310-fm578rm5 135 18 amoxicillin amoxicillin NNP cord-011310-fm578rm5 135 19 and and CC cord-011310-fm578rm5 135 20 1 1 CD cord-011310-fm578rm5 135 21 g g NN cord-011310-fm578rm5 135 22 per per IN cord-011310-fm578rm5 135 23 day day NN cord-011310-fm578rm5 135 24 clarithromycin clarithromycin NNS cord-011310-fm578rm5 135 25 was be VBD cord-011310-fm578rm5 135 26 used use VBN cord-011310-fm578rm5 135 27 in in IN cord-011310-fm578rm5 135 28 the the DT cord-011310-fm578rm5 135 29 estimates estimate NNS cord-011310-fm578rm5 135 30 , , , cord-011310-fm578rm5 135 31 considering consider VBG cord-011310-fm578rm5 135 32 that that IN cord-011310-fm578rm5 135 33 Latvia Latvia NNP cord-011310-fm578rm5 135 34 still still RB cord-011310-fm578rm5 135 35 belongs belong VBZ cord-011310-fm578rm5 135 36 to to IN cord-011310-fm578rm5 135 37 low low JJ cord-011310-fm578rm5 135 38 H. h. NN cord-011310-fm578rm5 135 39 pylori pylori NN cord-011310-fm578rm5 135 40 resistance resistance NN cord-011310-fm578rm5 135 41 areas area NNS cord-011310-fm578rm5 135 42 to to IN cord-011310-fm578rm5 135 43 clarithromycin clarithromycin NNS cord-011310-fm578rm5 135 44 , , , cord-011310-fm578rm5 135 45 and and CC cord-011310-fm578rm5 135 46 therefore therefore RB cord-011310-fm578rm5 135 47 , , , cord-011310-fm578rm5 135 48 clarithromycin clarithromycin NNP cord-011310-fm578rm5 135 49 - - HYPH cord-011310-fm578rm5 135 50 based base VBN cord-011310-fm578rm5 135 51 triple triple JJ cord-011310-fm578rm5 135 52 therapy therapy NN cord-011310-fm578rm5 135 53 could could MD cord-011310-fm578rm5 135 54 be be VB cord-011310-fm578rm5 135 55 considered consider VBN cord-011310-fm578rm5 135 56 the the DT cord-011310-fm578rm5 135 57 first first JJ cord-011310-fm578rm5 135 58 choice choice NN cord-011310-fm578rm5 135 59 . . . cord-011310-fm578rm5 136 1 The the DT cord-011310-fm578rm5 136 2 prevalence prevalence NN cord-011310-fm578rm5 136 3 of of IN cord-011310-fm578rm5 136 4 the the DT cord-011310-fm578rm5 136 5 infection infection NN cord-011310-fm578rm5 136 6 was be VBD cord-011310-fm578rm5 136 7 considered consider VBN cord-011310-fm578rm5 136 8 60 60 CD cord-011310-fm578rm5 136 9 % % NN cord-011310-fm578rm5 136 10 , , , cord-011310-fm578rm5 136 11 based base VBN cord-011310-fm578rm5 136 12 on on IN cord-011310-fm578rm5 136 13 our -PRON- PRP$ cord-011310-fm578rm5 136 14 previous previous JJ cord-011310-fm578rm5 136 15 studies study NNS cord-011310-fm578rm5 136 16 [ [ -LRB- cord-011310-fm578rm5 136 17 66 66 CD cord-011310-fm578rm5 136 18 ] ] -RRB- cord-011310-fm578rm5 136 19 . . . cord-011310-fm578rm5 137 1 Three three CD cord-011310-fm578rm5 137 2 different different JJ cord-011310-fm578rm5 137 3 scenarios scenario NNS cord-011310-fm578rm5 137 4 for for IN cord-011310-fm578rm5 137 5 a a DT cord-011310-fm578rm5 137 6 screen screen NN cord-011310-fm578rm5 137 7 - - HYPH cord-011310-fm578rm5 137 8 and and CC cord-011310-fm578rm5 137 9 - - HYPH cord-011310-fm578rm5 137 10 treat treat VB cord-011310-fm578rm5 137 11 strategy strategy NN cord-011310-fm578rm5 137 12 were be VBD cord-011310-fm578rm5 137 13 evaluated evaluate VBN cord-011310-fm578rm5 137 14 : : : cord-011310-fm578rm5 137 15 ( ( -LRB- cord-011310-fm578rm5 137 16 1 1 LS cord-011310-fm578rm5 137 17 ) ) -RRB- cord-011310-fm578rm5 137 18 eradication eradication NN cord-011310-fm578rm5 137 19 is be VBZ cord-011310-fm578rm5 137 20 limited limit VBN cord-011310-fm578rm5 137 21 every every DT cord-011310-fm578rm5 137 22 year year NN cord-011310-fm578rm5 137 23 just just RB cord-011310-fm578rm5 137 24 to to IN cord-011310-fm578rm5 137 25 persons person NNS cord-011310-fm578rm5 137 26 reaching reach VBG cord-011310-fm578rm5 137 27 adulthood-18 adulthood-18 CD cord-011310-fm578rm5 137 28 years year NNS cord-011310-fm578rm5 137 29 of of IN cord-011310-fm578rm5 137 30 age age NN cord-011310-fm578rm5 137 31 ; ; : cord-011310-fm578rm5 137 32 for for IN cord-011310-fm578rm5 137 33 the the DT cord-011310-fm578rm5 137 34 estimates estimate NNS cord-011310-fm578rm5 137 35 we -PRON- PRP cord-011310-fm578rm5 137 36 considered consider VBD cord-011310-fm578rm5 137 37 a a DT cord-011310-fm578rm5 137 38 100 100 CD cord-011310-fm578rm5 137 39 % % NN cord-011310-fm578rm5 137 40 adherence adherence NN cord-011310-fm578rm5 137 41 rate rate NN cord-011310-fm578rm5 137 42 , , , cord-011310-fm578rm5 137 43 since since IN cord-011310-fm578rm5 137 44 it -PRON- PRP cord-011310-fm578rm5 137 45 was be VBD cord-011310-fm578rm5 137 46 expected expect VBN cord-011310-fm578rm5 137 47 that that IN cord-011310-fm578rm5 137 48 the the DT cord-011310-fm578rm5 137 49 campaign campaign NN cord-011310-fm578rm5 137 50 would would MD cord-011310-fm578rm5 137 51 result result VB cord-011310-fm578rm5 137 52 in in IN cord-011310-fm578rm5 137 53 additional additional JJ cord-011310-fm578rm5 137 54 therapies therapy NNS cord-011310-fm578rm5 137 55 outside outside IN cord-011310-fm578rm5 137 56 the the DT cord-011310-fm578rm5 137 57 target target NN cord-011310-fm578rm5 137 58 group group NN cord-011310-fm578rm5 137 59 ; ; : cord-011310-fm578rm5 137 60 ( ( -LRB- cord-011310-fm578rm5 137 61 2 2 LS cord-011310-fm578rm5 137 62 ) ) -RRB- cord-011310-fm578rm5 137 63 within within IN cord-011310-fm578rm5 137 64 a a DT cord-011310-fm578rm5 137 65 3-year 3-year CD cord-011310-fm578rm5 137 66 period period NN cord-011310-fm578rm5 137 67 , , , cord-011310-fm578rm5 137 68 screen screen NN cord-011310-fm578rm5 137 69 - - HYPH cord-011310-fm578rm5 137 70 and and CC cord-011310-fm578rm5 137 71 - - HYPH cord-011310-fm578rm5 137 72 treat treat NN cord-011310-fm578rm5 137 73 would would MD cord-011310-fm578rm5 137 74 be be VB cord-011310-fm578rm5 137 75 offered offer VBN cord-011310-fm578rm5 137 76 to to IN cord-011310-fm578rm5 137 77 the the DT cord-011310-fm578rm5 137 78 risk risk NN cord-011310-fm578rm5 137 79 - - HYPH cord-011310-fm578rm5 137 80 group group NN cord-011310-fm578rm5 137 81 defined define VBN cord-011310-fm578rm5 137 82 as as IN cord-011310-fm578rm5 137 83 40 40 CD cord-011310-fm578rm5 137 84 - - HYPH cord-011310-fm578rm5 137 85 64-year 64-year JJ cord-011310-fm578rm5 137 86 - - HYPH cord-011310-fm578rm5 137 87 old old JJ cord-011310-fm578rm5 137 88 individuals individual NNS cord-011310-fm578rm5 137 89 ; ; : cord-011310-fm578rm5 137 90 one one CD cord-011310-fm578rm5 137 91 third third NN cord-011310-fm578rm5 137 92 of of IN cord-011310-fm578rm5 137 93 the the DT cord-011310-fm578rm5 137 94 target target NN cord-011310-fm578rm5 137 95 group group NN cord-011310-fm578rm5 137 96 would would MD cord-011310-fm578rm5 137 97 be be VB cord-011310-fm578rm5 137 98 covered cover VBN cord-011310-fm578rm5 137 99 per per IN cord-011310-fm578rm5 137 100 year year NN cord-011310-fm578rm5 137 101 with with IN cord-011310-fm578rm5 137 102 the the DT cord-011310-fm578rm5 137 103 70 70 CD cord-011310-fm578rm5 137 104 % % NN cord-011310-fm578rm5 137 105 compliance compliance NN cord-011310-fm578rm5 137 106 as as IN cord-011310-fm578rm5 137 107 an an DT cord-011310-fm578rm5 137 108 assumption assumption NN cord-011310-fm578rm5 137 109 ; ; : cord-011310-fm578rm5 137 110 ( ( -LRB- cord-011310-fm578rm5 137 111 3 3 LS cord-011310-fm578rm5 137 112 ) ) -RRB- cord-011310-fm578rm5 137 113 within within IN cord-011310-fm578rm5 137 114 a a DT cord-011310-fm578rm5 137 115 3-year 3-year CD cord-011310-fm578rm5 137 116 period period NN cord-011310-fm578rm5 137 117 , , , cord-011310-fm578rm5 137 118 screen screen NN cord-011310-fm578rm5 137 119 - - HYPH cord-011310-fm578rm5 137 120 and and CC cord-011310-fm578rm5 137 121 - - HYPH cord-011310-fm578rm5 137 122 treat treat NN cord-011310-fm578rm5 137 123 would would MD cord-011310-fm578rm5 137 124 be be VB cord-011310-fm578rm5 137 125 offered offer VBN cord-011310-fm578rm5 137 126 to to IN cord-011310-fm578rm5 137 127 all all DT cord-011310-fm578rm5 137 128 adult adult NN cord-011310-fm578rm5 137 129 individuals individual NNS cord-011310-fm578rm5 137 130 assuming assume VBG cord-011310-fm578rm5 137 131 a a DT cord-011310-fm578rm5 137 132 similar similar JJ cord-011310-fm578rm5 137 133 70 70 CD cord-011310-fm578rm5 137 134 % % NN cord-011310-fm578rm5 137 135 compliance compliance NN cord-011310-fm578rm5 137 136 rate rate NN cord-011310-fm578rm5 137 137 . . . cord-011310-fm578rm5 138 1 For for IN cord-011310-fm578rm5 138 2 scenarios scenario NNS cord-011310-fm578rm5 138 3 2 2 CD cord-011310-fm578rm5 138 4 and and CC cord-011310-fm578rm5 138 5 3 3 CD cord-011310-fm578rm5 138 6 , , , cord-011310-fm578rm5 138 7 additional additional JJ cord-011310-fm578rm5 138 8 eradication eradication NN cord-011310-fm578rm5 138 9 of of IN cord-011310-fm578rm5 138 10 the the DT cord-011310-fm578rm5 138 11 group group NN cord-011310-fm578rm5 138 12 reaching reach VBG cord-011310-fm578rm5 138 13 adulthood adulthood NN cord-011310-fm578rm5 138 14 was be VBD cord-011310-fm578rm5 138 15 considered consider VBN cord-011310-fm578rm5 138 16 starting start VBG cord-011310-fm578rm5 138 17 from from IN cord-011310-fm578rm5 138 18 year year NN cord-011310-fm578rm5 138 19 2 2 CD cord-011310-fm578rm5 138 20 . . . cord-011310-fm578rm5 139 1 The the DT cord-011310-fm578rm5 139 2 results result NNS cord-011310-fm578rm5 139 3 are be VBP cord-011310-fm578rm5 139 4 given give VBN cord-011310-fm578rm5 139 5 in in IN cord-011310-fm578rm5 139 6 Fig Fig NNP cord-011310-fm578rm5 139 7 . . . cord-011310-fm578rm5 140 1 1 1 LS cord-011310-fm578rm5 140 2 . . . cord-011310-fm578rm5 141 1 Scenario scenario NN cord-011310-fm578rm5 141 2 1 1 CD cord-011310-fm578rm5 141 3 would would MD cord-011310-fm578rm5 141 4 lead lead VB cord-011310-fm578rm5 141 5 to to IN cord-011310-fm578rm5 141 6 a a DT cord-011310-fm578rm5 141 7 moderate moderate JJ cord-011310-fm578rm5 141 8 increase increase NN cord-011310-fm578rm5 141 9 in in IN cord-011310-fm578rm5 141 10 clarithromycin clarithromycin NNS cord-011310-fm578rm5 141 11 and and CC cord-011310-fm578rm5 141 12 amoxicillin amoxicillin NNP cord-011310-fm578rm5 141 13 consumption consumption NN cord-011310-fm578rm5 141 14 , , , cord-011310-fm578rm5 141 15 Scenario scenario NN cord-011310-fm578rm5 141 16 2 2 CD cord-011310-fm578rm5 141 17 to to IN cord-011310-fm578rm5 141 18 ~ ~ NFP cord-011310-fm578rm5 141 19 threefold threefold JJ cord-011310-fm578rm5 141 20 increase increase NN cord-011310-fm578rm5 141 21 , , , cord-011310-fm578rm5 141 22 but but CC cord-011310-fm578rm5 141 23 Scenario scenario NN cord-011310-fm578rm5 141 24 3 3 CD cord-011310-fm578rm5 141 25 to to TO cord-011310-fm578rm5 141 26 more more JJR cord-011310-fm578rm5 141 27 than than IN cord-011310-fm578rm5 141 28 a a DT cord-011310-fm578rm5 141 29 sixfold sixfold JJ cord-011310-fm578rm5 141 30 increase increase NN cord-011310-fm578rm5 141 31 of of IN cord-011310-fm578rm5 141 32 clarithromycin clarithromycin NNS cord-011310-fm578rm5 141 33 , , , cord-011310-fm578rm5 141 34 with with IN cord-011310-fm578rm5 141 35 a a DT cord-011310-fm578rm5 141 36 slightly slightly RB cord-011310-fm578rm5 141 37 lower low JJR cord-011310-fm578rm5 141 38 ( ( -LRB- cord-011310-fm578rm5 141 39 twofold twofold NN cord-011310-fm578rm5 141 40 ) ) -RRB- cord-011310-fm578rm5 141 41 increase increase NN cord-011310-fm578rm5 141 42 in in IN cord-011310-fm578rm5 141 43 amoxicillin amoxicillin JJ cord-011310-fm578rm5 141 44 consumption consumption NN cord-011310-fm578rm5 141 45 . . . cord-011310-fm578rm5 142 1 Such such PDT cord-011310-fm578rm5 142 2 an an DT cord-011310-fm578rm5 142 3 increase increase NN cord-011310-fm578rm5 142 4 in in IN cord-011310-fm578rm5 142 5 antibiotic antibiotic JJ cord-011310-fm578rm5 142 6 consumption consumption NN cord-011310-fm578rm5 142 7 would would MD cord-011310-fm578rm5 142 8 move move VB cord-011310-fm578rm5 142 9 Latvia Latvia NNP cord-011310-fm578rm5 142 10 from from IN cord-011310-fm578rm5 142 11 a a DT cord-011310-fm578rm5 142 12 group group NN cord-011310-fm578rm5 142 13 of of IN cord-011310-fm578rm5 142 14 countries country NNS cord-011310-fm578rm5 142 15 with with IN cord-011310-fm578rm5 142 16 low low JJ cord-011310-fm578rm5 142 17 antibiotic antibiotic JJ cord-011310-fm578rm5 142 18 consumption consumption NN cord-011310-fm578rm5 142 19 to to IN cord-011310-fm578rm5 142 20 a a DT cord-011310-fm578rm5 142 21 group group NN cord-011310-fm578rm5 142 22 with with IN cord-011310-fm578rm5 142 23 average average JJ cord-011310-fm578rm5 142 24 antibiotic antibiotic JJ cord-011310-fm578rm5 142 25 consumption consumption NN cord-011310-fm578rm5 142 26 ( ( -LRB- cord-011310-fm578rm5 142 27 see see VB cord-011310-fm578rm5 142 28 Fig Fig NNP cord-011310-fm578rm5 142 29 . . NNP cord-011310-fm578rm5 142 30 2 2 CD cord-011310-fm578rm5 142 31 ; ; : cord-011310-fm578rm5 142 32 data datum NNS cord-011310-fm578rm5 142 33 on on IN cord-011310-fm578rm5 142 34 antibiotic antibiotic JJ cord-011310-fm578rm5 142 35 consumption consumption NN cord-011310-fm578rm5 142 36 _SP cord-011310-fm578rm5 142 37 Vaccine Vaccine NNP cord-011310-fm578rm5 142 38 ( ( -LRB- cord-011310-fm578rm5 142 39 either either CC cord-011310-fm578rm5 142 40 preventive preventive JJ cord-011310-fm578rm5 142 41 or or CC cord-011310-fm578rm5 142 42 therapeutic therapeutic JJ cord-011310-fm578rm5 142 43 ) ) -RRB- cord-011310-fm578rm5 142 44 would would MD cord-011310-fm578rm5 142 45 be be VB cord-011310-fm578rm5 142 46 potentially potentially RB cord-011310-fm578rm5 142 47 the the DT cord-011310-fm578rm5 142 48 best good JJS cord-011310-fm578rm5 142 49 solution solution NN cord-011310-fm578rm5 142 50 of of IN cord-011310-fm578rm5 142 51 the the DT cord-011310-fm578rm5 142 52 problem problem NN cord-011310-fm578rm5 142 53 [ [ -LRB- cord-011310-fm578rm5 142 54 10 10 CD cord-011310-fm578rm5 142 55 , , , cord-011310-fm578rm5 142 56 11 11 CD cord-011310-fm578rm5 142 57 ] ] -RRB- cord-011310-fm578rm5 142 58 ; ; : cord-011310-fm578rm5 142 59 however however RB cord-011310-fm578rm5 142 60 , , , cord-011310-fm578rm5 142 61 current current JJ cord-011310-fm578rm5 142 62 developments development NNS cord-011310-fm578rm5 142 63 have have VBP cord-011310-fm578rm5 142 64 not not RB cord-011310-fm578rm5 142 65 been be VBN cord-011310-fm578rm5 142 66 promising promise VBG cord-011310-fm578rm5 142 67 . . . cord-011310-fm578rm5 143 1 Non non JJ cord-011310-fm578rm5 143 2 - - JJ cord-011310-fm578rm5 143 3 antibiotic antibiotic JJ cord-011310-fm578rm5 143 4 H. h. NN cord-011310-fm578rm5 143 5 pylori pylori NN cord-011310-fm578rm5 143 6 eradication eradication NN cord-011310-fm578rm5 143 7 regimens regimen NNS cord-011310-fm578rm5 143 8 have have VBP cord-011310-fm578rm5 143 9 gained gain VBN cord-011310-fm578rm5 143 10 significant significant JJ cord-011310-fm578rm5 143 11 clinical clinical JJ cord-011310-fm578rm5 143 12 interest interest NN cord-011310-fm578rm5 143 13 . . . cord-011310-fm578rm5 144 1 The the DT cord-011310-fm578rm5 144 2 use use NN cord-011310-fm578rm5 144 3 of of IN cord-011310-fm578rm5 144 4 natural natural JJ cord-011310-fm578rm5 144 5 products product NNS cord-011310-fm578rm5 144 6 , , , cord-011310-fm578rm5 144 7 including include VBG cord-011310-fm578rm5 144 8 various various JJ cord-011310-fm578rm5 144 9 plant plant NN cord-011310-fm578rm5 144 10 ( ( -LRB- cord-011310-fm578rm5 144 11 even even RB cord-011310-fm578rm5 144 12 mushroom mushroom NN cord-011310-fm578rm5 144 13 ) ) -RRB- cord-011310-fm578rm5 144 14 and and CC cord-011310-fm578rm5 144 15 fruit fruit NN cord-011310-fm578rm5 144 16 extracts extract NNS cord-011310-fm578rm5 144 17 , , , cord-011310-fm578rm5 144 18 natural natural JJ cord-011310-fm578rm5 144 19 oils oil NNS cord-011310-fm578rm5 144 20 , , , cord-011310-fm578rm5 144 21 Chinese chinese JJ cord-011310-fm578rm5 144 22 herbs herb NNS cord-011310-fm578rm5 144 23 , , , cord-011310-fm578rm5 144 24 garlic garlic NN cord-011310-fm578rm5 144 25 , , , cord-011310-fm578rm5 144 26 ginger ginger NN cord-011310-fm578rm5 144 27 , , , cord-011310-fm578rm5 144 28 green green JJ cord-011310-fm578rm5 144 29 tea tea NN cord-011310-fm578rm5 144 30 , , , cord-011310-fm578rm5 144 31 curcumin curcumin NN cord-011310-fm578rm5 144 32 , , , cord-011310-fm578rm5 144 33 cranberries cranberry NNS cord-011310-fm578rm5 144 34 and and CC cord-011310-fm578rm5 144 35 pistacia pistacia NN cord-011310-fm578rm5 144 36 gum gum NN cord-011310-fm578rm5 144 37 have have VBP cord-011310-fm578rm5 144 38 been be VBN cord-011310-fm578rm5 144 39 studied study VBN cord-011310-fm578rm5 144 40 , , , cord-011310-fm578rm5 144 41 predominantly predominantly RB cord-011310-fm578rm5 144 42 under under IN cord-011310-fm578rm5 144 43 laboratory laboratory NN cord-011310-fm578rm5 144 44 conditions condition NNS cord-011310-fm578rm5 144 45 [ [ -LRB- cord-011310-fm578rm5 144 46 67 67 CD cord-011310-fm578rm5 144 47 ] ] -RRB- cord-011310-fm578rm5 145 1 [ [ -LRB- cord-011310-fm578rm5 145 2 68 68 CD cord-011310-fm578rm5 145 3 ] ] -RRB- cord-011310-fm578rm5 145 4 [ [ -LRB- cord-011310-fm578rm5 145 5 69 69 CD cord-011310-fm578rm5 145 6 ] ] -RRB- cord-011310-fm578rm5 145 7 [ [ -LRB- cord-011310-fm578rm5 145 8 70 70 CD cord-011310-fm578rm5 145 9 ] ] -RRB- cord-011310-fm578rm5 145 10 . . . cord-011310-fm578rm5 146 1 Some some DT cord-011310-fm578rm5 146 2 of of IN cord-011310-fm578rm5 146 3 these these DT cord-011310-fm578rm5 146 4 compounds compound NNS cord-011310-fm578rm5 146 5 had have VBD cord-011310-fm578rm5 146 6 activity activity NN cord-011310-fm578rm5 146 7 against against IN cord-011310-fm578rm5 146 8 H. H. NNP cord-011310-fm578rm5 146 9 pylori pylori NN cord-011310-fm578rm5 146 10 , , , cord-011310-fm578rm5 146 11 but but CC cord-011310-fm578rm5 146 12 the the DT cord-011310-fm578rm5 146 13 results result NNS cord-011310-fm578rm5 146 14 of of IN cord-011310-fm578rm5 146 15 clinical clinical JJ cord-011310-fm578rm5 146 16 evaluations evaluation NNS cord-011310-fm578rm5 146 17 in in IN cord-011310-fm578rm5 146 18 monotherapies monotherapie NNS cord-011310-fm578rm5 146 19 have have VBP cord-011310-fm578rm5 146 20 been be VBN cord-011310-fm578rm5 146 21 less less RBR cord-011310-fm578rm5 146 22 promising promising JJ cord-011310-fm578rm5 146 23 ; ; : cord-011310-fm578rm5 146 24 also also RB cord-011310-fm578rm5 146 25 , , , cord-011310-fm578rm5 146 26 the the DT cord-011310-fm578rm5 146 27 quality quality NN cord-011310-fm578rm5 146 28 of of IN cord-011310-fm578rm5 146 29 these these DT cord-011310-fm578rm5 146 30 trials trial NNS cord-011310-fm578rm5 146 31 has have VBZ cord-011310-fm578rm5 146 32 been be VBN cord-011310-fm578rm5 146 33 criticized criticize VBN cord-011310-fm578rm5 146 34 [ [ -LRB- cord-011310-fm578rm5 146 35 67 67 CD cord-011310-fm578rm5 146 36 ] ] -RRB- cord-011310-fm578rm5 146 37 . . . cord-011310-fm578rm5 147 1 Probiotics probiotic NNS cord-011310-fm578rm5 147 2 as as IN cord-011310-fm578rm5 147 3 a a DT cord-011310-fm578rm5 147 4 single single JJ cord-011310-fm578rm5 147 5 agent agent NN cord-011310-fm578rm5 147 6 have have VBP cord-011310-fm578rm5 147 7 been be VBN cord-011310-fm578rm5 147 8 also also RB cord-011310-fm578rm5 147 9 used use VBN cord-011310-fm578rm5 147 10 without without IN cord-011310-fm578rm5 147 11 major major JJ cord-011310-fm578rm5 147 12 success success NN cord-011310-fm578rm5 147 13 [ [ -LRB- cord-011310-fm578rm5 147 14 71 71 CD cord-011310-fm578rm5 147 15 ] ] -RRB- cord-011310-fm578rm5 147 16 . . . cord-011310-fm578rm5 148 1 Laboratory laboratory NN cord-011310-fm578rm5 148 2 and and CC cord-011310-fm578rm5 148 3 animal animal NN cord-011310-fm578rm5 148 4 experiments experiment NNS cord-011310-fm578rm5 148 5 show show VBP cord-011310-fm578rm5 148 6 the the DT cord-011310-fm578rm5 148 7 effectiveness effectiveness NN cord-011310-fm578rm5 148 8 of of IN cord-011310-fm578rm5 148 9 several several JJ cord-011310-fm578rm5 148 10 non non JJ cord-011310-fm578rm5 148 11 - - JJ cord-011310-fm578rm5 148 12 antibiotic antibiotic JJ cord-011310-fm578rm5 148 13 treatment treatment NN cord-011310-fm578rm5 148 14 modalities modality NNS cord-011310-fm578rm5 148 15 against against IN cord-011310-fm578rm5 148 16 H. H. NNP cord-011310-fm578rm5 148 17 pylori pylori NN cord-011310-fm578rm5 148 18 . . . cord-011310-fm578rm5 149 1 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 149 2 polypeptides polypeptide NNS cord-011310-fm578rm5 150 1 ( ( -LRB- cord-011310-fm578rm5 150 2 pH ph JJ cord-011310-fm578rm5 150 3 - - HYPH cord-011310-fm578rm5 150 4 sensitive sensitive JJ cord-011310-fm578rm5 150 5 , , , cord-011310-fm578rm5 150 6 helix helix NN cord-011310-fm578rm5 150 7 - - HYPH cord-011310-fm578rm5 150 8 coil coil NN cord-011310-fm578rm5 150 9 conformation conformation NN cord-011310-fm578rm5 150 10 transitionable transitionable NN cord-011310-fm578rm5 150 11 agent agent NN cord-011310-fm578rm5 150 12 with with IN cord-011310-fm578rm5 150 13 a a DT cord-011310-fm578rm5 150 14 bactericidal bactericidal JJ cord-011310-fm578rm5 150 15 activity activity NN cord-011310-fm578rm5 150 16 ) ) -RRB- cord-011310-fm578rm5 150 17 have have VBP cord-011310-fm578rm5 150 18 been be VBN cord-011310-fm578rm5 150 19 developed develop VBN cord-011310-fm578rm5 150 20 to to TO cord-011310-fm578rm5 150 21 target target VB cord-011310-fm578rm5 150 22 and and CC cord-011310-fm578rm5 150 23 selectively selectively RB cord-011310-fm578rm5 150 24 eradicate eradicate VB cord-011310-fm578rm5 150 25 H. H. NNP cord-011310-fm578rm5 150 26 pylori pylori NN cord-011310-fm578rm5 150 27 as as IN cord-011310-fm578rm5 150 28 a a DT cord-011310-fm578rm5 150 29 single single JJ cord-011310-fm578rm5 150 30 therapeutic therapeutic JJ cord-011310-fm578rm5 150 31 agent agent NN cord-011310-fm578rm5 150 32 , , , cord-011310-fm578rm5 150 33 without without IN cord-011310-fm578rm5 150 34 significant significant JJ cord-011310-fm578rm5 150 35 effects effect NNS cord-011310-fm578rm5 150 36 on on IN cord-011310-fm578rm5 150 37 commensal commensal JJ cord-011310-fm578rm5 150 38 bacteria bacteria NNS cord-011310-fm578rm5 150 39 [ [ -LRB- cord-011310-fm578rm5 150 40 72 72 CD cord-011310-fm578rm5 150 41 ] ] -RRB- cord-011310-fm578rm5 150 42 . . . cord-011310-fm578rm5 151 1 Another another DT cord-011310-fm578rm5 151 2 group group NN cord-011310-fm578rm5 151 3 developed develop VBD cord-011310-fm578rm5 151 4 docosahexaenoic docosahexaenoic NNP cord-011310-fm578rm5 151 5 acid acid NN cord-011310-fm578rm5 151 6 - - HYPH cord-011310-fm578rm5 151 7 loaded load VBN cord-011310-fm578rm5 151 8 lipid lipid NN cord-011310-fm578rm5 151 9 nanoparticles nanoparticle NNS cord-011310-fm578rm5 151 10 with with IN cord-011310-fm578rm5 151 11 bactericidal bactericidal JJ cord-011310-fm578rm5 151 12 activity activity NN cord-011310-fm578rm5 151 13 against against IN cord-011310-fm578rm5 151 14 H. H. NNP cord-011310-fm578rm5 151 15 pylori pylori NN cord-011310-fm578rm5 151 16 [ [ -LRB- cord-011310-fm578rm5 151 17 73 73 CD cord-011310-fm578rm5 151 18 ] ] -RRB- cord-011310-fm578rm5 151 19 . . . cord-011310-fm578rm5 152 1 This this DT cord-011310-fm578rm5 152 2 bactericidal bactericidal JJ cord-011310-fm578rm5 152 3 in in IN cord-011310-fm578rm5 152 4 Latvia Latvia NNP cord-011310-fm578rm5 152 5 compared compare VBN cord-011310-fm578rm5 152 6 to to IN cord-011310-fm578rm5 152 7 other other JJ cord-011310-fm578rm5 152 8 countries country NNS cord-011310-fm578rm5 152 9 in in IN cord-011310-fm578rm5 152 10 the the DT cord-011310-fm578rm5 152 11 European European NNP cord-011310-fm578rm5 152 12 Union Union NNP cord-011310-fm578rm5 152 13 / / SYM cord-011310-fm578rm5 152 14 European European NNP cord-011310-fm578rm5 152 15 Economic Economic NNP cord-011310-fm578rm5 152 16 area area NN cord-011310-fm578rm5 152 17 , , , cord-011310-fm578rm5 152 18 with with IN cord-011310-fm578rm5 152 19 the the DT cord-011310-fm578rm5 152 20 hypothetical hypothetical JJ cord-011310-fm578rm5 152 21 scenarios scenario NNS cord-011310-fm578rm5 152 22 of of IN cord-011310-fm578rm5 152 23 an an DT cord-011310-fm578rm5 152 24 H. H. NNP cord-011310-fm578rm5 152 25 pylori pylori NN cord-011310-fm578rm5 152 26 screenand screenand NN cord-011310-fm578rm5 152 27 - - HYPH cord-011310-fm578rm5 152 28 treat treat NN cord-011310-fm578rm5 152 29 strategy strategy NN cord-011310-fm578rm5 152 30 expressed express VBN cord-011310-fm578rm5 152 31 as as IN cord-011310-fm578rm5 152 32 DDD DDD NNP cord-011310-fm578rm5 152 33 per per IN cord-011310-fm578rm5 152 34 1000 1000 CD cord-011310-fm578rm5 152 35 inhabitants inhabitant NNS cord-011310-fm578rm5 152 36 per per IN cord-011310-fm578rm5 152 37 day day NN cord-011310-fm578rm5 152 38 . . . cord-011310-fm578rm5 153 1 Note note VB cord-011310-fm578rm5 153 2 : : : cord-011310-fm578rm5 153 3 The the DT cord-011310-fm578rm5 153 4 bars bar NNS cord-011310-fm578rm5 153 5 in in IN cord-011310-fm578rm5 153 6 blue blue JJ cord-011310-fm578rm5 153 7 indicate indicate VBP cord-011310-fm578rm5 153 8 the the DT cord-011310-fm578rm5 153 9 current current JJ cord-011310-fm578rm5 153 10 consumption consumption NN cord-011310-fm578rm5 153 11 of of IN cord-011310-fm578rm5 153 12 antibacterials antibacterial NNS cord-011310-fm578rm5 153 13 ( ( -LRB- cord-011310-fm578rm5 153 14 including include VBG cord-011310-fm578rm5 153 15 Latvia Latvia NNP cord-011310-fm578rm5 153 16 ) ) -RRB- cord-011310-fm578rm5 153 17 . . . cord-011310-fm578rm5 154 1 The the DT cord-011310-fm578rm5 154 2 bars bar NNS cord-011310-fm578rm5 154 3 in in IN cord-011310-fm578rm5 154 4 red red JJ cord-011310-fm578rm5 154 5 are be VBP cord-011310-fm578rm5 154 6 consumption consumption NN cord-011310-fm578rm5 154 7 of of IN cord-011310-fm578rm5 154 8 antibacterials antibacterial NNS cord-011310-fm578rm5 154 9 in in IN cord-011310-fm578rm5 154 10 Latvia Latvia NNP cord-011310-fm578rm5 154 11 with with IN cord-011310-fm578rm5 154 12 various various JJ cord-011310-fm578rm5 154 13 scenarios scenario NNS cord-011310-fm578rm5 154 14 during during IN cord-011310-fm578rm5 154 15 the the DT cord-011310-fm578rm5 154 16 first first JJ cord-011310-fm578rm5 154 17 year year NN cord-011310-fm578rm5 154 18 of of IN cord-011310-fm578rm5 154 19 a a DT cord-011310-fm578rm5 154 20 screenand screenand NN cord-011310-fm578rm5 154 21 - - HYPH cord-011310-fm578rm5 154 22 treat treat VB cord-011310-fm578rm5 154 23 strategy strategy NN cord-011310-fm578rm5 154 24 implementation implementation NN cord-011310-fm578rm5 154 25 . . . cord-011310-fm578rm5 155 1 Scenario scenario NN cord-011310-fm578rm5 155 2 1 1 CD cord-011310-fm578rm5 155 3 : : : cord-011310-fm578rm5 155 4 eradication eradication NN cord-011310-fm578rm5 155 5 limited limit VBN cord-011310-fm578rm5 155 6 to to IN cord-011310-fm578rm5 155 7 anybody anybody NN cord-011310-fm578rm5 155 8 reaching reach VBG cord-011310-fm578rm5 155 9 18 18 CD cord-011310-fm578rm5 155 10 years year NNS cord-011310-fm578rm5 155 11 of of IN cord-011310-fm578rm5 155 12 age age NN cord-011310-fm578rm5 155 13 . . . cord-011310-fm578rm5 156 1 Scenario scenario NN cord-011310-fm578rm5 156 2 2 2 CD cord-011310-fm578rm5 156 3 : : : cord-011310-fm578rm5 156 4 the the DT cord-011310-fm578rm5 156 5 age age NN cord-011310-fm578rm5 156 6 group group NN cord-011310-fm578rm5 156 7 40 40 CD cord-011310-fm578rm5 156 8 - - SYM cord-011310-fm578rm5 156 9 64 64 CD cord-011310-fm578rm5 156 10 years year NNS cord-011310-fm578rm5 156 11 invited invite VBN cord-011310-fm578rm5 156 12 for for IN cord-011310-fm578rm5 156 13 screen screen NN cord-011310-fm578rm5 156 14 - - HYPH cord-011310-fm578rm5 156 15 and and CC cord-011310-fm578rm5 156 16 - - HYPH cord-011310-fm578rm5 156 17 treat treat NN cord-011310-fm578rm5 156 18 within within IN cord-011310-fm578rm5 156 19 a a DT cord-011310-fm578rm5 156 20 3-year 3-year CD cord-011310-fm578rm5 156 21 period period NN cord-011310-fm578rm5 156 22 ; ; : cord-011310-fm578rm5 156 23 70 70 CD cord-011310-fm578rm5 156 24 % % NN cord-011310-fm578rm5 156 25 compliance compliance NN cord-011310-fm578rm5 156 26 . . . cord-011310-fm578rm5 157 1 Scenario scenario NN cord-011310-fm578rm5 157 2 3 3 CD cord-011310-fm578rm5 157 3 : : : cord-011310-fm578rm5 157 4 all all DT cord-011310-fm578rm5 157 5 adults adult NNS cord-011310-fm578rm5 157 6 invited invite VBN cord-011310-fm578rm5 157 7 for for IN cord-011310-fm578rm5 157 8 screen screen NN cord-011310-fm578rm5 157 9 - - HYPH cord-011310-fm578rm5 157 10 and and CC cord-011310-fm578rm5 157 11 - - HYPH cord-011310-fm578rm5 157 12 treat treat NN cord-011310-fm578rm5 157 13 within within IN cord-011310-fm578rm5 157 14 a a DT cord-011310-fm578rm5 157 15 3-year 3-year CD cord-011310-fm578rm5 157 16 period period NN cord-011310-fm578rm5 158 1 ; ; : cord-011310-fm578rm5 158 2 70 70 CD cord-011310-fm578rm5 158 3 % % NN cord-011310-fm578rm5 158 4 compliance compliance NN cord-011310-fm578rm5 158 5 agent agent NN cord-011310-fm578rm5 158 6 could could MD cord-011310-fm578rm5 158 7 also also RB cord-011310-fm578rm5 158 8 eradicate eradicate VB cord-011310-fm578rm5 158 9 H. h. NN cord-011310-fm578rm5 158 10 pylori pylori NN cord-011310-fm578rm5 158 11 without without IN cord-011310-fm578rm5 158 12 affecting affect VBG cord-011310-fm578rm5 158 13 the the DT cord-011310-fm578rm5 158 14 other other JJ cord-011310-fm578rm5 158 15 bacteria bacteria NNS cord-011310-fm578rm5 158 16 ( ( -LRB- cord-011310-fm578rm5 158 17 Lactobacillus Lactobacillus NNP cord-011310-fm578rm5 158 18 , , , cord-011310-fm578rm5 158 19 E. E. NNP cord-011310-fm578rm5 158 20 coli coli NNS cord-011310-fm578rm5 158 21 , , , cord-011310-fm578rm5 158 22 S. S. NNP cord-011310-fm578rm5 158 23 epidermidis epidermidi NNS cord-011310-fm578rm5 158 24 and and CC cord-011310-fm578rm5 158 25 S. S. NNP cord-011310-fm578rm5 158 26 aureus aureus NN cord-011310-fm578rm5 158 27 ) ) -RRB- cord-011310-fm578rm5 159 1 [ [ -LRB- cord-011310-fm578rm5 159 2 74 74 CD cord-011310-fm578rm5 159 3 ] ] -RRB- cord-011310-fm578rm5 159 4 . . . cord-011310-fm578rm5 160 1 Since since IN cord-011310-fm578rm5 160 2 the the DT cord-011310-fm578rm5 160 3 abovementioned abovementioned JJ cord-011310-fm578rm5 160 4 approaches approach NNS cord-011310-fm578rm5 160 5 are be VBP cord-011310-fm578rm5 160 6 still still RB cord-011310-fm578rm5 160 7 far far RB cord-011310-fm578rm5 160 8 from from IN cord-011310-fm578rm5 160 9 clinical clinical JJ cord-011310-fm578rm5 160 10 practice practice NN cord-011310-fm578rm5 160 11 , , , cord-011310-fm578rm5 160 12 regimens regimen NNS cord-011310-fm578rm5 160 13 that that WDT cord-011310-fm578rm5 160 14 are be VBP cord-011310-fm578rm5 160 15 expected expect VBN cord-011310-fm578rm5 160 16 to to TO cord-011310-fm578rm5 160 17 interfere interfere VB cord-011310-fm578rm5 160 18 less less RBR cord-011310-fm578rm5 160 19 with with IN cord-011310-fm578rm5 160 20 the the DT cord-011310-fm578rm5 160 21 microbiota microbiota NN cord-011310-fm578rm5 160 22 and and CC cord-011310-fm578rm5 160 23 less less RBR cord-011310-fm578rm5 160 24 likely likely JJ cord-011310-fm578rm5 160 25 to to TO cord-011310-fm578rm5 160 26 be be VB cord-011310-fm578rm5 160 27 responsible responsible JJ cord-011310-fm578rm5 160 28 for for IN cord-011310-fm578rm5 160 29 gut gut NN cord-011310-fm578rm5 160 30 ( ( -LRB- cord-011310-fm578rm5 160 31 and and CC cord-011310-fm578rm5 160 32 other other JJ cord-011310-fm578rm5 160 33 location location NN cord-011310-fm578rm5 160 34 ) ) -RRB- cord-011310-fm578rm5 161 1 resistome resistome NNP cord-011310-fm578rm5 161 2 development development NN cord-011310-fm578rm5 161 3 are be VBP cord-011310-fm578rm5 161 4 more more RBR cord-011310-fm578rm5 161 5 attractive attractive JJ cord-011310-fm578rm5 161 6 for for IN cord-011310-fm578rm5 161 7 clinical clinical JJ cord-011310-fm578rm5 161 8 applications application NNS cord-011310-fm578rm5 161 9 in in IN cord-011310-fm578rm5 161 10 the the DT cord-011310-fm578rm5 161 11 near near JJ cord-011310-fm578rm5 161 12 future future NN cord-011310-fm578rm5 161 13 . . . cord-011310-fm578rm5 162 1 Single single JJ cord-011310-fm578rm5 162 2 antibiotic antibiotic JJ cord-011310-fm578rm5 162 3 regimens regimen NNS cord-011310-fm578rm5 162 4 , , , cord-011310-fm578rm5 162 5 in in IN cord-011310-fm578rm5 162 6 particular particular JJ cord-011310-fm578rm5 162 7 those those DT cord-011310-fm578rm5 162 8 not not RB cord-011310-fm578rm5 162 9 containing contain VBG cord-011310-fm578rm5 162 10 macrolides macrolide NNS cord-011310-fm578rm5 162 11 , , , cord-011310-fm578rm5 162 12 could could MD cord-011310-fm578rm5 162 13 attract attract VB cord-011310-fm578rm5 162 14 interest interest NN cord-011310-fm578rm5 162 15 in in IN cord-011310-fm578rm5 162 16 this this DT cord-011310-fm578rm5 162 17 respect respect NN cord-011310-fm578rm5 162 18 . . . cord-011310-fm578rm5 163 1 Use use NN cord-011310-fm578rm5 163 2 of of IN cord-011310-fm578rm5 163 3 high high JJ cord-011310-fm578rm5 163 4 - - HYPH cord-011310-fm578rm5 163 5 dose dose NN cord-011310-fm578rm5 163 6 amoxicillin amoxicillin NNP cord-011310-fm578rm5 163 7 is be VBZ cord-011310-fm578rm5 163 8 one one CD cord-011310-fm578rm5 163 9 case case NN cord-011310-fm578rm5 163 10 , , , cord-011310-fm578rm5 163 11 although although IN cord-011310-fm578rm5 163 12 more more RBR cord-011310-fm578rm5 163 13 frequent frequent JJ cord-011310-fm578rm5 163 14 dosing dosing NN cord-011310-fm578rm5 163 15 is be VBZ cord-011310-fm578rm5 163 16 required require VBN cord-011310-fm578rm5 163 17 due due IN cord-011310-fm578rm5 163 18 to to IN cord-011310-fm578rm5 163 19 the the DT cord-011310-fm578rm5 163 20 pharmacokinetics pharmacokinetic NNS cord-011310-fm578rm5 163 21 of of IN cord-011310-fm578rm5 163 22 this this DT cord-011310-fm578rm5 163 23 drug drug NN cord-011310-fm578rm5 163 24 . . . cord-011310-fm578rm5 164 1 High high JJ cord-011310-fm578rm5 164 2 - - HYPH cord-011310-fm578rm5 164 3 dose dose NN cord-011310-fm578rm5 164 4 amoxicillin amoxicillin NNP cord-011310-fm578rm5 164 5 - - HYPH cord-011310-fm578rm5 164 6 based base VBN cord-011310-fm578rm5 164 7 dual dual JJ cord-011310-fm578rm5 164 8 therapy therapy NN cord-011310-fm578rm5 164 9 for for IN cord-011310-fm578rm5 164 10 first first JJ cord-011310-fm578rm5 164 11 - - HYPH cord-011310-fm578rm5 164 12 line line NN cord-011310-fm578rm5 164 13 H. h. NN cord-011310-fm578rm5 164 14 pylori pylori NN cord-011310-fm578rm5 164 15 eradication eradication NN cord-011310-fm578rm5 164 16 has have VBZ cord-011310-fm578rm5 164 17 so so RB cord-011310-fm578rm5 164 18 far far RB cord-011310-fm578rm5 164 19 been be VBN cord-011310-fm578rm5 164 20 evaluated evaluate VBN cord-011310-fm578rm5 164 21 predominantly predominantly RB cord-011310-fm578rm5 164 22 in in IN cord-011310-fm578rm5 164 23 Asia Asia NNP cord-011310-fm578rm5 164 24 [ [ -LRB- cord-011310-fm578rm5 164 25 75 75 CD cord-011310-fm578rm5 164 26 , , , cord-011310-fm578rm5 164 27 76 76 CD cord-011310-fm578rm5 164 28 ] ] -RRB- cord-011310-fm578rm5 164 29 , , , cord-011310-fm578rm5 164 30 although although IN cord-011310-fm578rm5 164 31 a a DT cord-011310-fm578rm5 164 32 pilot pilot NN cord-011310-fm578rm5 164 33 study study NN cord-011310-fm578rm5 164 34 has have VBZ cord-011310-fm578rm5 164 35 been be VBN cord-011310-fm578rm5 164 36 reported report VBN cord-011310-fm578rm5 164 37 in in IN cord-011310-fm578rm5 164 38 Europe Europe NNP cord-011310-fm578rm5 164 39 [ [ -LRB- cord-011310-fm578rm5 164 40 77 77 CD cord-011310-fm578rm5 164 41 ] ] -RRB- cord-011310-fm578rm5 164 42 . . . cord-011310-fm578rm5 165 1 More more RBR cord-011310-fm578rm5 165 2 profound profound JJ cord-011310-fm578rm5 165 3 reduction reduction NN cord-011310-fm578rm5 165 4 of of IN cord-011310-fm578rm5 165 5 the the DT cord-011310-fm578rm5 165 6 gastric gastric JJ cord-011310-fm578rm5 165 7 acidity acidity NN cord-011310-fm578rm5 165 8 also also RB cord-011310-fm578rm5 165 9 could could MD cord-011310-fm578rm5 165 10 contribute contribute VB cord-011310-fm578rm5 165 11 to to IN cord-011310-fm578rm5 165 12 a a DT cord-011310-fm578rm5 165 13 higher high JJR cord-011310-fm578rm5 165 14 effectiveness effectiveness NN cord-011310-fm578rm5 165 15 of of IN cord-011310-fm578rm5 165 16 the the DT cord-011310-fm578rm5 165 17 therapy therapy NN cord-011310-fm578rm5 165 18 . . . cord-011310-fm578rm5 166 1 Sugimoto Sugimoto NNP cord-011310-fm578rm5 166 2 and and CC cord-011310-fm578rm5 166 3 Yamaoka Yamaoka NNP cord-011310-fm578rm5 166 4 [ [ -LRB- cord-011310-fm578rm5 166 5 64 64 CD cord-011310-fm578rm5 166 6 ] ] -RRB- cord-011310-fm578rm5 166 7 have have VBP cord-011310-fm578rm5 166 8 recently recently RB cord-011310-fm578rm5 166 9 reviewed review VBN cord-011310-fm578rm5 166 10 the the DT cord-011310-fm578rm5 166 11 effectiveness effectiveness NN cord-011310-fm578rm5 166 12 of of IN cord-011310-fm578rm5 166 13 PCAB PCAB NNP cord-011310-fm578rm5 166 14 in in IN cord-011310-fm578rm5 166 15 H. H. NNP cord-011310-fm578rm5 166 16 pylori pylori NN cord-011310-fm578rm5 166 17 eradication eradication NN cord-011310-fm578rm5 166 18 therapies therapy NNS cord-011310-fm578rm5 166 19 compared compare VBN cord-011310-fm578rm5 166 20 to to IN cord-011310-fm578rm5 166 21 the the DT cord-011310-fm578rm5 166 22 traditional traditional JJ cord-011310-fm578rm5 166 23 PPI PPI NNP cord-011310-fm578rm5 166 24 containing contain VBG cord-011310-fm578rm5 166 25 therapies therapy NNS cord-011310-fm578rm5 166 26 , , , cord-011310-fm578rm5 166 27 and and CC cord-011310-fm578rm5 166 28 demonstrated demonstrate VBD cord-011310-fm578rm5 166 29 significant significant JJ cord-011310-fm578rm5 166 30 advantages advantage NNS cord-011310-fm578rm5 166 31 of of IN cord-011310-fm578rm5 166 32 the the DT cord-011310-fm578rm5 166 33 PCAB PCAB NNP cord-011310-fm578rm5 166 34 . . . cord-011310-fm578rm5 167 1 Therefore therefore RB cord-011310-fm578rm5 167 2 , , , cord-011310-fm578rm5 167 3 one one CD cord-011310-fm578rm5 167 4 directions direction NNS cord-011310-fm578rm5 167 5 for for IN cord-011310-fm578rm5 167 6 future future JJ cord-011310-fm578rm5 167 7 therapies therapy NNS cord-011310-fm578rm5 167 8 could could MD cord-011310-fm578rm5 167 9 be be VB cord-011310-fm578rm5 167 10 PCAB PCAB NNP cord-011310-fm578rm5 167 11 and and CC cord-011310-fm578rm5 167 12 high high JJ cord-011310-fm578rm5 167 13 - - HYPH cord-011310-fm578rm5 167 14 dose dose NN cord-011310-fm578rm5 167 15 ( ( -LRB- cord-011310-fm578rm5 167 16 multiple multiple JJ cord-011310-fm578rm5 167 17 dose dose NN cord-011310-fm578rm5 167 18 ) ) -RRB- cord-011310-fm578rm5 167 19 amoxicillin amoxicillin NNP cord-011310-fm578rm5 167 20 in in IN cord-011310-fm578rm5 167 21 combination combination NN cord-011310-fm578rm5 167 22 . . . cord-011310-fm578rm5 168 1 Another another DT cord-011310-fm578rm5 168 2 approach approach NN cord-011310-fm578rm5 168 3 would would MD cord-011310-fm578rm5 168 4 be be VB cord-011310-fm578rm5 168 5 the the DT cord-011310-fm578rm5 168 6 use use NN cord-011310-fm578rm5 168 7 of of IN cord-011310-fm578rm5 168 8 antimicrobial antimicrobial JJ cord-011310-fm578rm5 168 9 agents agent NNS cord-011310-fm578rm5 168 10 that that WDT cord-011310-fm578rm5 168 11 are be VBP cord-011310-fm578rm5 168 12 not not RB cord-011310-fm578rm5 168 13 typically typically RB cord-011310-fm578rm5 168 14 used use VBN cord-011310-fm578rm5 168 15 in in IN cord-011310-fm578rm5 168 16 managing manage VBG cord-011310-fm578rm5 168 17 life life NN cord-011310-fm578rm5 168 18 - - HYPH cord-011310-fm578rm5 168 19 threatening threaten VBG cord-011310-fm578rm5 168 20 disease disease NN cord-011310-fm578rm5 168 21 , , , cord-011310-fm578rm5 168 22 as as RB cord-011310-fm578rm5 168 23 well well RB cord-011310-fm578rm5 168 24 as as IN cord-011310-fm578rm5 168 25 those those DT cord-011310-fm578rm5 168 26 causing cause VBG cord-011310-fm578rm5 168 27 less less JJR cord-011310-fm578rm5 168 28 induction induction NN cord-011310-fm578rm5 168 29 of of IN cord-011310-fm578rm5 168 30 the the DT cord-011310-fm578rm5 168 31 pool pool NN cord-011310-fm578rm5 168 32 resistant resistant JJ cord-011310-fm578rm5 168 33 genes gene NNS cord-011310-fm578rm5 168 34 . . . cord-011310-fm578rm5 169 1 Bismuth Bismuth NNP cord-011310-fm578rm5 169 2 - - HYPH cord-011310-fm578rm5 169 3 based base VBN cord-011310-fm578rm5 169 4 therapies therapy NNS cord-011310-fm578rm5 169 5 are be VBP cord-011310-fm578rm5 169 6 mainly mainly RB cord-011310-fm578rm5 169 7 used use VBN cord-011310-fm578rm5 169 8 to to TO cord-011310-fm578rm5 169 9 overcome overcome VB cord-011310-fm578rm5 169 10 the the DT cord-011310-fm578rm5 169 11 resistance resistance NN cord-011310-fm578rm5 169 12 of of IN cord-011310-fm578rm5 169 13 H. H. NNP cord-011310-fm578rm5 169 14 pylori pylori NN cord-011310-fm578rm5 169 15 to to TO cord-011310-fm578rm5 169 16 commonly commonly RB cord-011310-fm578rm5 169 17 used use VBN cord-011310-fm578rm5 169 18 antibiotics antibiotic NNS cord-011310-fm578rm5 169 19 in in IN cord-011310-fm578rm5 169 20 clinical clinical JJ cord-011310-fm578rm5 169 21 settings setting NNS cord-011310-fm578rm5 169 22 [ [ -LRB- cord-011310-fm578rm5 169 23 10 10 CD cord-011310-fm578rm5 169 24 , , , cord-011310-fm578rm5 169 25 78 78 CD cord-011310-fm578rm5 169 26 , , , cord-011310-fm578rm5 169 27 79 79 CD cord-011310-fm578rm5 169 28 ] ] -RRB- cord-011310-fm578rm5 169 29 . . . cord-011310-fm578rm5 170 1 An an DT cord-011310-fm578rm5 170 2 additional additional JJ cord-011310-fm578rm5 170 3 gain gain NN cord-011310-fm578rm5 170 4 with with IN cord-011310-fm578rm5 170 5 these these DT cord-011310-fm578rm5 170 6 therapies therapy NNS cord-011310-fm578rm5 170 7 is be VBZ cord-011310-fm578rm5 170 8 avoiding avoid VBG cord-011310-fm578rm5 170 9 the the DT cord-011310-fm578rm5 170 10 use use NN cord-011310-fm578rm5 170 11 of of IN cord-011310-fm578rm5 170 12 clarithromycin clarithromycin NNP cord-011310-fm578rm5 170 13 and and CC cord-011310-fm578rm5 170 14 amoxicillin amoxicillin NNP cord-011310-fm578rm5 170 15 . . . cord-011310-fm578rm5 171 1 However however RB cord-011310-fm578rm5 171 2 , , , cord-011310-fm578rm5 171 3 bismuth bismuth NN cord-011310-fm578rm5 171 4 is be VBZ cord-011310-fm578rm5 171 5 not not RB cord-011310-fm578rm5 171 6 available available JJ cord-011310-fm578rm5 171 7 in in IN cord-011310-fm578rm5 171 8 many many JJ cord-011310-fm578rm5 171 9 countries country NNS cord-011310-fm578rm5 171 10 . . . cord-011310-fm578rm5 172 1 The the DT cord-011310-fm578rm5 172 2 concern concern NN cord-011310-fm578rm5 172 3 with with IN cord-011310-fm578rm5 172 4 bismuth bismuth NN cord-011310-fm578rm5 172 5 - - HYPH cord-011310-fm578rm5 172 6 related relate VBN cord-011310-fm578rm5 172 7 adverse adverse JJ cord-011310-fm578rm5 172 8 events event NNS cord-011310-fm578rm5 172 9 is be VBZ cord-011310-fm578rm5 172 10 predominantly predominantly RB cord-011310-fm578rm5 172 11 related relate VBN cord-011310-fm578rm5 172 12 to to IN cord-011310-fm578rm5 172 13 the the DT cord-011310-fm578rm5 172 14 fact fact NN cord-011310-fm578rm5 172 15 that that IN cord-011310-fm578rm5 172 16 in in IN cord-011310-fm578rm5 172 17 the the DT cord-011310-fm578rm5 172 18 1970s 1970 NNS cord-011310-fm578rm5 172 19 , , , cord-011310-fm578rm5 172 20 use use NN cord-011310-fm578rm5 172 21 of of IN cord-011310-fm578rm5 172 22 high high JJ cord-011310-fm578rm5 172 23 - - HYPH cord-011310-fm578rm5 172 24 dose dose NN cord-011310-fm578rm5 172 25 bismuth bismuth NN cord-011310-fm578rm5 172 26 salts salt NNS cord-011310-fm578rm5 172 27 for for IN cord-011310-fm578rm5 172 28 long long JJ cord-011310-fm578rm5 172 29 periods period NNS cord-011310-fm578rm5 172 30 was be VBD cord-011310-fm578rm5 172 31 associated associate VBN cord-011310-fm578rm5 172 32 with with IN cord-011310-fm578rm5 172 33 neurotoxicity neurotoxicity NN cord-011310-fm578rm5 172 34 ; ; : cord-011310-fm578rm5 172 35 however however RB cord-011310-fm578rm5 172 36 , , , cord-011310-fm578rm5 172 37 systemic systemic JJ cord-011310-fm578rm5 172 38 review review NN cord-011310-fm578rm5 172 39 and and CC cord-011310-fm578rm5 172 40 meta meta NNP cord-011310-fm578rm5 172 41 - - HYPH cord-011310-fm578rm5 172 42 analysis analysis NN cord-011310-fm578rm5 172 43 on on IN cord-011310-fm578rm5 172 44 bismuth bismuth NN cord-011310-fm578rm5 172 45 use use NN cord-011310-fm578rm5 172 46 for for IN cord-011310-fm578rm5 172 47 H. h. NN cord-011310-fm578rm5 172 48 pylori pylori NN cord-011310-fm578rm5 172 49 eradication eradication NN cord-011310-fm578rm5 172 50 did do VBD cord-011310-fm578rm5 172 51 not not RB cord-011310-fm578rm5 172 52 reveal reveal VB cord-011310-fm578rm5 172 53 serious serious JJ cord-011310-fm578rm5 172 54 adverse adverse JJ cord-011310-fm578rm5 172 55 events event NNS cord-011310-fm578rm5 172 56 for for IN cord-011310-fm578rm5 172 57 such such JJ cord-011310-fm578rm5 172 58 therapy therapy NN cord-011310-fm578rm5 172 59 [ [ -LRB- cord-011310-fm578rm5 172 60 80 80 CD cord-011310-fm578rm5 172 61 ] ] -RRB- cord-011310-fm578rm5 172 62 . . . cord-011310-fm578rm5 173 1 A a DT cord-011310-fm578rm5 173 2 recent recent JJ cord-011310-fm578rm5 173 3 meta meta JJ cord-011310-fm578rm5 173 4 - - HYPH cord-011310-fm578rm5 173 5 analysis analysis NN cord-011310-fm578rm5 173 6 by by IN cord-011310-fm578rm5 173 7 Ko Ko NNP cord-011310-fm578rm5 173 8 et et NNP cord-011310-fm578rm5 173 9 al al NNP cord-011310-fm578rm5 173 10 . . . cord-011310-fm578rm5 174 1 [ [ -LRB- cord-011310-fm578rm5 174 2 81 81 CD cord-011310-fm578rm5 174 3 ] ] -RRB- cord-011310-fm578rm5 174 4 has have VBZ cord-011310-fm578rm5 174 5 suggested suggest VBN cord-011310-fm578rm5 174 6 the the DT cord-011310-fm578rm5 174 7 superiority superiority NN cord-011310-fm578rm5 174 8 of of IN cord-011310-fm578rm5 174 9 bismuth bismuth NN cord-011310-fm578rm5 174 10 - - HYPH cord-011310-fm578rm5 174 11 containing contain VBG cord-011310-fm578rm5 174 12 therapies therapy NNS cord-011310-fm578rm5 174 13 over over IN cord-011310-fm578rm5 174 14 nonbismuth nonbismuth NNP cord-011310-fm578rm5 174 15 regimens regimen NNS cord-011310-fm578rm5 174 16 ; ; : cord-011310-fm578rm5 174 17 furthermore furthermore RB cord-011310-fm578rm5 174 18 , , , cord-011310-fm578rm5 174 19 adding add VBG cord-011310-fm578rm5 174 20 bismuth bismuth NN cord-011310-fm578rm5 174 21 to to IN cord-011310-fm578rm5 174 22 conventional conventional JJ cord-011310-fm578rm5 174 23 standard standard JJ cord-011310-fm578rm5 174 24 eradication eradication NN cord-011310-fm578rm5 174 25 regimens regimen NNS cord-011310-fm578rm5 174 26 provides provide VBZ cord-011310-fm578rm5 174 27 additional additional JJ cord-011310-fm578rm5 174 28 gain gain NN cord-011310-fm578rm5 174 29 in in IN cord-011310-fm578rm5 174 30 the the DT cord-011310-fm578rm5 174 31 efficacy efficacy NN cord-011310-fm578rm5 174 32 of of IN cord-011310-fm578rm5 174 33 the the DT cord-011310-fm578rm5 174 34 therapies therapy NNS cord-011310-fm578rm5 174 35 . . . cord-011310-fm578rm5 175 1 Another another DT cord-011310-fm578rm5 175 2 meta meta JJ cord-011310-fm578rm5 175 3 - - HYPH cord-011310-fm578rm5 175 4 analysis analysis NN cord-011310-fm578rm5 175 5 on on IN cord-011310-fm578rm5 175 6 a a DT cord-011310-fm578rm5 175 7 single single JJ cord-011310-fm578rm5 175 8 capsule capsule NN cord-011310-fm578rm5 175 9 10-day 10-day CD cord-011310-fm578rm5 175 10 bismuth bismuth NN cord-011310-fm578rm5 175 11 - - HYPH cord-011310-fm578rm5 175 12 containing contain VBG cord-011310-fm578rm5 175 13 quadruple quadruple JJ cord-011310-fm578rm5 175 14 therapy therapy NN cord-011310-fm578rm5 175 15 has have VBZ cord-011310-fm578rm5 175 16 suggested suggest VBN cord-011310-fm578rm5 175 17 ~ ~ CD cord-011310-fm578rm5 175 18 90 90 CD cord-011310-fm578rm5 175 19 % % NN cord-011310-fm578rm5 175 20 eradication eradication NN cord-011310-fm578rm5 175 21 success success NN cord-011310-fm578rm5 175 22 both both CC cord-011310-fm578rm5 175 23 in in IN cord-011310-fm578rm5 175 24 first first JJ cord-011310-fm578rm5 175 25 - - HYPH cord-011310-fm578rm5 175 26 and and CC cord-011310-fm578rm5 175 27 second second JJ cord-011310-fm578rm5 175 28 - - HYPH cord-011310-fm578rm5 175 29 line line NN cord-011310-fm578rm5 175 30 therapy therapy NN cord-011310-fm578rm5 175 31 [ [ -LRB- cord-011310-fm578rm5 175 32 82 82 CD cord-011310-fm578rm5 175 33 ] ] -RRB- cord-011310-fm578rm5 175 34 . . . cord-011310-fm578rm5 176 1 Short short JJ cord-011310-fm578rm5 176 2 - - HYPH cord-011310-fm578rm5 176 3 term term NN cord-011310-fm578rm5 176 4 dysbiosis dysbiosis NN cord-011310-fm578rm5 176 5 restoration restoration NN cord-011310-fm578rm5 176 6 to to IN cord-011310-fm578rm5 176 7 baseline baseline JJ cord-011310-fm578rm5 176 8 levels level NNS cord-011310-fm578rm5 176 9 within within IN cord-011310-fm578rm5 176 10 an an DT cord-011310-fm578rm5 176 11 8-week 8-week CD cord-011310-fm578rm5 176 12 period period NN cord-011310-fm578rm5 176 13 following follow VBG cord-011310-fm578rm5 176 14 14-day 14-day CD cord-011310-fm578rm5 176 15 bismuth bismuth NN cord-011310-fm578rm5 176 16 quadruple quadruple JJ cord-011310-fm578rm5 176 17 therapy therapy NN cord-011310-fm578rm5 176 18 has have VBZ cord-011310-fm578rm5 176 19 been be VBN cord-011310-fm578rm5 176 20 reported report VBN cord-011310-fm578rm5 176 21 from from IN cord-011310-fm578rm5 176 22 Taiwan Taiwan NNP cord-011310-fm578rm5 176 23 ; ; , cord-011310-fm578rm5 176 24 16S 16S NNP cord-011310-fm578rm5 176 25 rRNA rrna NN cord-011310-fm578rm5 176 26 gene gene NN cord-011310-fm578rm5 176 27 sequencing sequencing NN cord-011310-fm578rm5 176 28 of of IN cord-011310-fm578rm5 176 29 the the DT cord-011310-fm578rm5 176 30 V3-V4 V3-V4 NNP cord-011310-fm578rm5 176 31 region region NN cord-011310-fm578rm5 176 32 and and CC cord-011310-fm578rm5 176 33 sampling sampling NN cord-011310-fm578rm5 176 34 before before IN cord-011310-fm578rm5 176 35 the the DT cord-011310-fm578rm5 176 36 treatment treatment NN cord-011310-fm578rm5 176 37 , , , cord-011310-fm578rm5 176 38 as as RB cord-011310-fm578rm5 176 39 well well RB cord-011310-fm578rm5 176 40 as as IN cord-011310-fm578rm5 176 41 2 2 CD cord-011310-fm578rm5 176 42 , , , cord-011310-fm578rm5 176 43 8 8 CD cord-011310-fm578rm5 176 44 , , , cord-011310-fm578rm5 176 45 and and CC cord-011310-fm578rm5 176 46 48 48 CD cord-011310-fm578rm5 176 47 weeks week NNS cord-011310-fm578rm5 176 48 thereafter thereafter RB cord-011310-fm578rm5 176 49 , , , cord-011310-fm578rm5 176 50 was be VBD cord-011310-fm578rm5 176 51 used use VBN cord-011310-fm578rm5 176 52 [ [ -LRB- cord-011310-fm578rm5 176 53 83 83 CD cord-011310-fm578rm5 176 54 ] ] -RRB- cord-011310-fm578rm5 176 55 . . . cord-011310-fm578rm5 177 1 Therefore therefore RB cord-011310-fm578rm5 177 2 , , , cord-011310-fm578rm5 177 3 bismuth bismuth NN cord-011310-fm578rm5 177 4 - - HYPH cord-011310-fm578rm5 177 5 containing contain VBG cord-011310-fm578rm5 177 6 quadruple quadruple JJ cord-011310-fm578rm5 177 7 therapy therapy NN cord-011310-fm578rm5 177 8 is be VBZ cord-011310-fm578rm5 177 9 also also RB cord-011310-fm578rm5 177 10 related relate VBN cord-011310-fm578rm5 177 11 to to IN cord-011310-fm578rm5 177 12 dysbiosis dysbiosis NN cord-011310-fm578rm5 177 13 ; ; : cord-011310-fm578rm5 177 14 other other JJ cord-011310-fm578rm5 177 15 antibacterial antibacterial JJ cord-011310-fm578rm5 177 16 agents agent NNS cord-011310-fm578rm5 177 17 contained contain VBN cord-011310-fm578rm5 177 18 in in IN cord-011310-fm578rm5 177 19 this this DT cord-011310-fm578rm5 177 20 treatment treatment NN cord-011310-fm578rm5 177 21 , , , cord-011310-fm578rm5 177 22 in in IN cord-011310-fm578rm5 177 23 particular particular JJ cord-011310-fm578rm5 177 24 metronidazole metronidazole NN cord-011310-fm578rm5 177 25 , , , cord-011310-fm578rm5 177 26 could could MD cord-011310-fm578rm5 177 27 be be VB cord-011310-fm578rm5 177 28 responsible responsible JJ cord-011310-fm578rm5 177 29 for for IN cord-011310-fm578rm5 177 30 perturbations perturbation NNS cord-011310-fm578rm5 177 31 in in IN cord-011310-fm578rm5 177 32 the the DT cord-011310-fm578rm5 177 33 microbiota microbiota NN cord-011310-fm578rm5 177 34 . . . cord-011310-fm578rm5 178 1 There there EX cord-011310-fm578rm5 178 2 are be VBP cord-011310-fm578rm5 178 3 still still RB cord-011310-fm578rm5 178 4 insufficient insufficient JJ cord-011310-fm578rm5 178 5 data datum NNS cord-011310-fm578rm5 178 6 on on IN cord-011310-fm578rm5 178 7 the the DT cord-011310-fm578rm5 178 8 potency potency NN cord-011310-fm578rm5 178 9 of of IN cord-011310-fm578rm5 178 10 bismuth bismuth NN cord-011310-fm578rm5 178 11 - - HYPH cord-011310-fm578rm5 178 12 based base VBN cord-011310-fm578rm5 178 13 therapies therapy NNS cord-011310-fm578rm5 178 14 to to TO cord-011310-fm578rm5 178 15 induce induce VB cord-011310-fm578rm5 178 16 and and CC cord-011310-fm578rm5 178 17 cause cause VB cord-011310-fm578rm5 178 18 persistent persistent JJ cord-011310-fm578rm5 178 19 resistome resistome NNP cord-011310-fm578rm5 178 20 . . . cord-011310-fm578rm5 179 1 An an DT cord-011310-fm578rm5 179 2 alternative alternative NN cord-011310-fm578rm5 179 3 to to IN cord-011310-fm578rm5 179 4 the the DT cord-011310-fm578rm5 179 5 empiric empiric JJ cord-011310-fm578rm5 179 6 eradication eradication NN cord-011310-fm578rm5 179 7 regimen regimen NN cord-011310-fm578rm5 179 8 is be VBZ cord-011310-fm578rm5 179 9 a a DT cord-011310-fm578rm5 179 10 H. h. NN cord-011310-fm578rm5 179 11 pylori pylori NN cord-011310-fm578rm5 179 12 susceptibility susceptibility NN cord-011310-fm578rm5 179 13 - - HYPH cord-011310-fm578rm5 179 14 based base VBN cord-011310-fm578rm5 179 15 individual individual JJ cord-011310-fm578rm5 179 16 therapy therapy NN cord-011310-fm578rm5 179 17 . . . cord-011310-fm578rm5 180 1 This this DT cord-011310-fm578rm5 180 2 allows allow VBZ cord-011310-fm578rm5 180 3 avoiding avoid VBG cord-011310-fm578rm5 180 4 unnecessary unnecessary JJ cord-011310-fm578rm5 180 5 use use NN cord-011310-fm578rm5 180 6 of of IN cord-011310-fm578rm5 180 7 antibiotics antibiotic NNS cord-011310-fm578rm5 180 8 and and CC cord-011310-fm578rm5 180 9 increasing increase VBG cord-011310-fm578rm5 180 10 the the DT cord-011310-fm578rm5 180 11 effectiveness effectiveness NN cord-011310-fm578rm5 180 12 of of IN cord-011310-fm578rm5 180 13 the the DT cord-011310-fm578rm5 180 14 treatment treatment NN cord-011310-fm578rm5 180 15 [ [ -LRB- cord-011310-fm578rm5 180 16 84 84 CD cord-011310-fm578rm5 180 17 ] ] -RRB- cord-011310-fm578rm5 180 18 . . . cord-011310-fm578rm5 181 1 However however RB cord-011310-fm578rm5 181 2 , , , cord-011310-fm578rm5 181 3 this this DT cord-011310-fm578rm5 181 4 is be VBZ cord-011310-fm578rm5 181 5 considering consider VBG cord-011310-fm578rm5 181 6 only only RB cord-011310-fm578rm5 181 7 H. h. NN cord-011310-fm578rm5 181 8 pylori pylori NN cord-011310-fm578rm5 181 9 resistance resistance NN cord-011310-fm578rm5 181 10 patterns pattern NNS cord-011310-fm578rm5 181 11 , , , cord-011310-fm578rm5 181 12 not not RB cord-011310-fm578rm5 181 13 the the DT cord-011310-fm578rm5 181 14 effects effect NNS cord-011310-fm578rm5 181 15 upon upon IN cord-011310-fm578rm5 181 16 the the DT cord-011310-fm578rm5 181 17 other other JJ cord-011310-fm578rm5 181 18 gut gut NN cord-011310-fm578rm5 181 19 microbiome microbiome NN cord-011310-fm578rm5 181 20 . . . cord-011310-fm578rm5 182 1 Usually usually RB cord-011310-fm578rm5 182 2 , , , cord-011310-fm578rm5 182 3 even even RB cord-011310-fm578rm5 182 4 after after IN cord-011310-fm578rm5 182 5 H. H. NNP cord-011310-fm578rm5 182 6 pylori pylori NN cord-011310-fm578rm5 182 7 resistance resistance NN cord-011310-fm578rm5 182 8 testing testing NN cord-011310-fm578rm5 182 9 , , , cord-011310-fm578rm5 182 10 several several JJ cord-011310-fm578rm5 182 11 options option NNS cord-011310-fm578rm5 182 12 for for IN cord-011310-fm578rm5 182 13 eradication eradication NN cord-011310-fm578rm5 182 14 therapies therapy NNS cord-011310-fm578rm5 182 15 are be VBP cord-011310-fm578rm5 182 16 remaining remain VBG cord-011310-fm578rm5 182 17 , , , cord-011310-fm578rm5 182 18 and and CC cord-011310-fm578rm5 182 19 lower low JJR cord-011310-fm578rm5 182 20 negative negative JJ cord-011310-fm578rm5 182 21 effects effect NNS cord-011310-fm578rm5 182 22 upon upon IN cord-011310-fm578rm5 182 23 the the DT cord-011310-fm578rm5 182 24 gut gut NN cord-011310-fm578rm5 182 25 microbiome microbiome NN cord-011310-fm578rm5 182 26 should should MD cord-011310-fm578rm5 182 27 ideally ideally RB cord-011310-fm578rm5 182 28 considered consider VBN cord-011310-fm578rm5 182 29 to to TO cord-011310-fm578rm5 182 30 be be VB cord-011310-fm578rm5 182 31 the the DT cord-011310-fm578rm5 182 32 choice choice NN cord-011310-fm578rm5 182 33 . . . cord-011310-fm578rm5 183 1 Finally finally RB cord-011310-fm578rm5 183 2 , , , cord-011310-fm578rm5 183 3 narrowing narrow VBG cord-011310-fm578rm5 183 4 the the DT cord-011310-fm578rm5 183 5 target target NN cord-011310-fm578rm5 183 6 group group NN cord-011310-fm578rm5 183 7 for for IN cord-011310-fm578rm5 183 8 H. H. NNP cord-011310-fm578rm5 183 9 pylori pylori NN cord-011310-fm578rm5 183 10 eradication eradication NN cord-011310-fm578rm5 183 11 , , , cord-011310-fm578rm5 183 12 e.g. e.g. RB cord-011310-fm578rm5 183 13 by by IN cord-011310-fm578rm5 183 14 targeting target VBG cord-011310-fm578rm5 183 15 young young JJ cord-011310-fm578rm5 183 16 adults adult NNS cord-011310-fm578rm5 183 17 before before IN cord-011310-fm578rm5 183 18 family family NN cord-011310-fm578rm5 183 19 planning planning NN cord-011310-fm578rm5 183 20 and and CC cord-011310-fm578rm5 183 21 , , , cord-011310-fm578rm5 183 22 therefore therefore RB cord-011310-fm578rm5 183 23 , , , cord-011310-fm578rm5 183 24 before before IN cord-011310-fm578rm5 183 25 the the DT cord-011310-fm578rm5 183 26 potential potential JJ cord-011310-fm578rm5 183 27 transmission transmission NN cord-011310-fm578rm5 183 28 of of IN cord-011310-fm578rm5 183 29 the the DT cord-011310-fm578rm5 183 30 infection infection NN cord-011310-fm578rm5 183 31 to to IN cord-011310-fm578rm5 183 32 offspring offspring NN cord-011310-fm578rm5 183 33 , , , cord-011310-fm578rm5 183 34 could could MD cord-011310-fm578rm5 183 35 be be VB cord-011310-fm578rm5 183 36 another another DT cord-011310-fm578rm5 183 37 approach approach NN cord-011310-fm578rm5 183 38 in in IN cord-011310-fm578rm5 183 39 decreasing decrease VBG cord-011310-fm578rm5 183 40 the the DT cord-011310-fm578rm5 183 41 misuse misuse NN cord-011310-fm578rm5 183 42 of of IN cord-011310-fm578rm5 183 43 antibiotics antibiotic NNS cord-011310-fm578rm5 183 44 . . . cord-011310-fm578rm5 184 1 In in IN cord-011310-fm578rm5 184 2 spite spite NN cord-011310-fm578rm5 184 3 of of IN cord-011310-fm578rm5 184 4 the the DT cord-011310-fm578rm5 184 5 failures failure NNS cord-011310-fm578rm5 184 6 mentioned mention VBN cord-011310-fm578rm5 184 7 above above RB cord-011310-fm578rm5 184 8 , , , cord-011310-fm578rm5 184 9 individual individual JJ cord-011310-fm578rm5 184 10 risk risk NN cord-011310-fm578rm5 184 11 stratification stratification NN cord-011310-fm578rm5 184 12 based base VBN cord-011310-fm578rm5 184 13 on on IN cord-011310-fm578rm5 184 14 gender gender NN cord-011310-fm578rm5 184 15 , , , cord-011310-fm578rm5 184 16 lifestyle lifestyle NN cord-011310-fm578rm5 184 17 factors factor NNS cord-011310-fm578rm5 184 18 , , , cord-011310-fm578rm5 184 19 host host NN cord-011310-fm578rm5 184 20 and and CC cord-011310-fm578rm5 184 21 H. H. NNP cord-011310-fm578rm5 184 22 pylori pylori NN cord-011310-fm578rm5 184 23 genetics genetic NNS cord-011310-fm578rm5 184 24 continue continue VBP cord-011310-fm578rm5 184 25 to to TO cord-011310-fm578rm5 184 26 be be VB cord-011310-fm578rm5 184 27 of of IN cord-011310-fm578rm5 184 28 interest interest NN cord-011310-fm578rm5 184 29 in in IN cord-011310-fm578rm5 184 30 risk risk NN cord-011310-fm578rm5 184 31 stratification stratification NN cord-011310-fm578rm5 184 32 . . . cord-011310-fm578rm5 185 1 Several several JJ cord-011310-fm578rm5 185 2 meta meta JJ cord-011310-fm578rm5 185 3 - - HYPH cord-011310-fm578rm5 185 4 analyses analysis NNS cord-011310-fm578rm5 185 5 have have VBP cord-011310-fm578rm5 185 6 suggested suggest VBN cord-011310-fm578rm5 185 7 convincing convincing JJ cord-011310-fm578rm5 185 8 cost cost NN cord-011310-fm578rm5 185 9 - - HYPH cord-011310-fm578rm5 185 10 effectiveness effectiveness NN cord-011310-fm578rm5 185 11 of of IN cord-011310-fm578rm5 185 12 population population NN cord-011310-fm578rm5 185 13 - - HYPH cord-011310-fm578rm5 185 14 wide wide JJ cord-011310-fm578rm5 185 15 H. h. NN cord-011310-fm578rm5 185 16 pylori pylori NN cord-011310-fm578rm5 185 17 eradication eradication NN cord-011310-fm578rm5 185 18 [ [ -LRB- cord-011310-fm578rm5 185 19 85 85 CD cord-011310-fm578rm5 185 20 ] ] -RRB- cord-011310-fm578rm5 185 21 [ [ -LRB- cord-011310-fm578rm5 185 22 86 86 CD cord-011310-fm578rm5 185 23 ] ] -RRB- cord-011310-fm578rm5 185 24 [ [ -LRB- cord-011310-fm578rm5 185 25 87 87 CD cord-011310-fm578rm5 185 26 ] ] -RRB- cord-011310-fm578rm5 185 27 . . . cord-011310-fm578rm5 186 1 The the DT cord-011310-fm578rm5 186 2 benefit benefit NN cord-011310-fm578rm5 186 3 is be VBZ cord-011310-fm578rm5 186 4 likely likely JJ cord-011310-fm578rm5 186 5 to to TO cord-011310-fm578rm5 186 6 be be VB cord-011310-fm578rm5 186 7 highest high JJS cord-011310-fm578rm5 186 8 in in IN cord-011310-fm578rm5 186 9 communities community NNS cord-011310-fm578rm5 186 10 with with IN cord-011310-fm578rm5 186 11 a a DT cord-011310-fm578rm5 186 12 high high JJ cord-011310-fm578rm5 186 13 risk risk NN cord-011310-fm578rm5 186 14 of of IN cord-011310-fm578rm5 186 15 gastric gastric JJ cord-011310-fm578rm5 186 16 cancer cancer NN cord-011310-fm578rm5 186 17 ; ; : cord-011310-fm578rm5 186 18 in in IN cord-011310-fm578rm5 186 19 developed develop VBN cord-011310-fm578rm5 186 20 countries country NNS cord-011310-fm578rm5 186 21 , , , cord-011310-fm578rm5 186 22 such such PDT cord-011310-fm578rm5 186 23 an an DT cord-011310-fm578rm5 186 24 approach approach NN cord-011310-fm578rm5 186 25 could could MD cord-011310-fm578rm5 186 26 be be VB cord-011310-fm578rm5 186 27 either either CC cord-011310-fm578rm5 186 28 cost cost NN cord-011310-fm578rm5 186 29 - - HYPH cord-011310-fm578rm5 186 30 effective effective JJ cord-011310-fm578rm5 186 31 or or CC cord-011310-fm578rm5 186 32 cost cost NN cord-011310-fm578rm5 186 33 - - HYPH cord-011310-fm578rm5 186 34 neutral neutral JJ cord-011310-fm578rm5 186 35 if if IN cord-011310-fm578rm5 186 36 considered consider VBN cord-011310-fm578rm5 186 37 on on IN cord-011310-fm578rm5 186 38 the the DT cord-011310-fm578rm5 186 39 positive positive JJ cord-011310-fm578rm5 186 40 side side NN cord-011310-fm578rm5 186 41 in in IN cord-011310-fm578rm5 186 42 reducing reduce VBG cord-011310-fm578rm5 186 43 the the DT cord-011310-fm578rm5 186 44 cost cost NN cord-011310-fm578rm5 186 45 of of IN cord-011310-fm578rm5 186 46 dyspepsia dyspepsia NN cord-011310-fm578rm5 186 47 treatment treatment NN cord-011310-fm578rm5 186 48 [ [ -LRB- cord-011310-fm578rm5 186 49 11 11 CD cord-011310-fm578rm5 186 50 ] ] -RRB- cord-011310-fm578rm5 186 51 . . . cord-011310-fm578rm5 187 1 Few few JJ cord-011310-fm578rm5 187 2 other other JJ cord-011310-fm578rm5 187 3 cost cost NN cord-011310-fm578rm5 187 4 - - HYPH cord-011310-fm578rm5 187 5 effectiveness effectiveness NN cord-011310-fm578rm5 187 6 studies study NNS cord-011310-fm578rm5 187 7 have have VBP cord-011310-fm578rm5 187 8 since since IN cord-011310-fm578rm5 187 9 been be VBN cord-011310-fm578rm5 187 10 published publish VBN cord-011310-fm578rm5 187 11 . . . cord-011310-fm578rm5 188 1 In in IN cord-011310-fm578rm5 188 2 Denmark Denmark NNP cord-011310-fm578rm5 188 3 , , , cord-011310-fm578rm5 188 4 a a DT cord-011310-fm578rm5 188 5 low low JJ cord-011310-fm578rm5 188 6 H. h. NN cord-011310-fm578rm5 188 7 pylori pylori NN cord-011310-fm578rm5 188 8 prevalence prevalence NN cord-011310-fm578rm5 188 9 country country NN cord-011310-fm578rm5 188 10 , , , cord-011310-fm578rm5 188 11 a a DT cord-011310-fm578rm5 188 12 13-year 13-year JJ cord-011310-fm578rm5 188 13 follow follow NN cord-011310-fm578rm5 188 14 - - HYPH cord-011310-fm578rm5 188 15 up up NN cord-011310-fm578rm5 188 16 of of IN cord-011310-fm578rm5 188 17 a a DT cord-011310-fm578rm5 188 18 randomized randomized JJ cord-011310-fm578rm5 188 19 study study NN cord-011310-fm578rm5 188 20 population population NN cord-011310-fm578rm5 188 21 ( ( -LRB- cord-011310-fm578rm5 188 22 20,011 20,011 CD cord-011310-fm578rm5 188 23 individuals individual NNS cord-011310-fm578rm5 188 24 aged age VBN cord-011310-fm578rm5 188 25 40 40 CD cord-011310-fm578rm5 188 26 - - SYM cord-011310-fm578rm5 188 27 65 65 CD cord-011310-fm578rm5 188 28 years year NNS cord-011310-fm578rm5 188 29 at at IN cord-011310-fm578rm5 188 30 enrollment enrollment NN cord-011310-fm578rm5 188 31 ) ) -RRB- cord-011310-fm578rm5 188 32 failed fail VBD cord-011310-fm578rm5 188 33 to to TO cord-011310-fm578rm5 188 34 achieve achieve VB cord-011310-fm578rm5 188 35 either either CC cord-011310-fm578rm5 188 36 quality quality NN cord-011310-fm578rm5 188 37 - - HYPH cord-011310-fm578rm5 188 38 of of IN cord-011310-fm578rm5 188 39 - - HYPH cord-011310-fm578rm5 188 40 life life NN cord-011310-fm578rm5 188 41 or or CC cord-011310-fm578rm5 188 42 cost cost NN cord-011310-fm578rm5 188 43 - - HYPH cord-011310-fm578rm5 188 44 effectiveness effectiveness NN cord-011310-fm578rm5 188 45 [ [ -LRB- cord-011310-fm578rm5 188 46 88 88 CD cord-011310-fm578rm5 188 47 ] ] -RRB- cord-011310-fm578rm5 188 48 , , , cord-011310-fm578rm5 188 49 whereas whereas IN cord-011310-fm578rm5 188 50 a a DT cord-011310-fm578rm5 188 51 modelling modelling NN cord-011310-fm578rm5 188 52 exercise exercise NN cord-011310-fm578rm5 188 53 in in IN cord-011310-fm578rm5 188 54 China China NNP cord-011310-fm578rm5 188 55 proved prove VBD cord-011310-fm578rm5 188 56 cost cost NN cord-011310-fm578rm5 188 57 - - HYPH cord-011310-fm578rm5 188 58 effective effective JJ cord-011310-fm578rm5 188 59 in in IN cord-011310-fm578rm5 188 60 a a DT cord-011310-fm578rm5 188 61 population population NN cord-011310-fm578rm5 188 62 - - HYPH cord-011310-fm578rm5 188 63 based base VBN cord-011310-fm578rm5 188 64 screen screen NN cord-011310-fm578rm5 188 65 - - HYPH cord-011310-fm578rm5 188 66 and and CC cord-011310-fm578rm5 188 67 - - HYPH cord-011310-fm578rm5 188 68 treat treat VB cord-011310-fm578rm5 188 69 strategy strategy NN cord-011310-fm578rm5 188 70 related relate VBN cord-011310-fm578rm5 188 71 to to IN cord-011310-fm578rm5 188 72 gastric gastric JJ cord-011310-fm578rm5 188 73 cancer cancer NN cord-011310-fm578rm5 188 74 , , , cord-011310-fm578rm5 188 75 peptic peptic JJ cord-011310-fm578rm5 188 76 ulcer ulcer NN cord-011310-fm578rm5 188 77 disease disease NN cord-011310-fm578rm5 188 78 and and CC cord-011310-fm578rm5 188 79 dyspepsia dyspepsia JJ cord-011310-fm578rm5 188 80 reduction reduction NN cord-011310-fm578rm5 188 81 . . . cord-011310-fm578rm5 189 1 Furthermore furthermore RB cord-011310-fm578rm5 189 2 , , , cord-011310-fm578rm5 189 3 the the DT cord-011310-fm578rm5 189 4 highest high JJS cord-011310-fm578rm5 189 5 effectiveness effectiveness NN cord-011310-fm578rm5 189 6 was be VBD cord-011310-fm578rm5 189 7 in in IN cord-011310-fm578rm5 189 8 the the DT cord-011310-fm578rm5 189 9 age age NN cord-011310-fm578rm5 189 10 group group NN cord-011310-fm578rm5 189 11 of of IN cord-011310-fm578rm5 189 12 20 20 CD cord-011310-fm578rm5 189 13 years year NNS cord-011310-fm578rm5 189 14 [ [ -LRB- cord-011310-fm578rm5 189 15 89 89 CD cord-011310-fm578rm5 189 16 ] ] -RRB- cord-011310-fm578rm5 189 17 . . . cord-011310-fm578rm5 190 1 Screen screen NN cord-011310-fm578rm5 190 2 - - HYPH cord-011310-fm578rm5 190 3 and and CC cord-011310-fm578rm5 190 4 - - HYPH cord-011310-fm578rm5 190 5 treat treat NN cord-011310-fm578rm5 190 6 has have VBZ cord-011310-fm578rm5 190 7 also also RB cord-011310-fm578rm5 190 8 been be VBN cord-011310-fm578rm5 190 9 estimated estimate VBN cord-011310-fm578rm5 190 10 as as IN cord-011310-fm578rm5 190 11 cost cost NN cord-011310-fm578rm5 190 12 - - HYPH cord-011310-fm578rm5 190 13 effective effective JJ cord-011310-fm578rm5 190 14 for for IN cord-011310-fm578rm5 190 15 employees employee NNS cord-011310-fm578rm5 190 16 in in IN cord-011310-fm578rm5 190 17 Japan Japan NNP cord-011310-fm578rm5 190 18 [ [ -LRB- cord-011310-fm578rm5 190 19 90 90 CD cord-011310-fm578rm5 190 20 ] ] -RRB- cord-011310-fm578rm5 190 21 . . . cord-011310-fm578rm5 191 1 However however RB cord-011310-fm578rm5 191 2 , , , cord-011310-fm578rm5 191 3 these these DT cord-011310-fm578rm5 191 4 studies study NNS cord-011310-fm578rm5 191 5 have have VBP cord-011310-fm578rm5 191 6 not not RB cord-011310-fm578rm5 191 7 considered consider VBN cord-011310-fm578rm5 191 8 the the DT cord-011310-fm578rm5 191 9 potential potential JJ cord-011310-fm578rm5 191 10 costs cost NNS cord-011310-fm578rm5 191 11 associated associate VBN cord-011310-fm578rm5 191 12 to to IN cord-011310-fm578rm5 191 13 the the DT cord-011310-fm578rm5 191 14 increase increase NN cord-011310-fm578rm5 191 15 in in IN cord-011310-fm578rm5 191 16 the the DT cord-011310-fm578rm5 191 17 pool pool NN cord-011310-fm578rm5 191 18 of of IN cord-011310-fm578rm5 191 19 resistant resistant JJ cord-011310-fm578rm5 191 20 bacteria bacteria NNS cord-011310-fm578rm5 191 21 . . . cord-011310-fm578rm5 192 1 The the DT cord-011310-fm578rm5 192 2 real real JJ cord-011310-fm578rm5 192 3 costs cost NNS cord-011310-fm578rm5 192 4 behind behind IN cord-011310-fm578rm5 192 5 the the DT cord-011310-fm578rm5 192 6 resistome resistome NNP cord-011310-fm578rm5 192 7 are be VBP cord-011310-fm578rm5 192 8 difficult difficult JJ cord-011310-fm578rm5 192 9 to to TO cord-011310-fm578rm5 192 10 estimate estimate VB cord-011310-fm578rm5 192 11 ; ; : cord-011310-fm578rm5 192 12 at at RB cord-011310-fm578rm5 192 13 least least RBS cord-011310-fm578rm5 192 14 two two CD cord-011310-fm578rm5 192 15 major major JJ cord-011310-fm578rm5 192 16 issues issue NNS cord-011310-fm578rm5 192 17 must must MD cord-011310-fm578rm5 192 18 be be VB cord-011310-fm578rm5 192 19 considered consider VBN cord-011310-fm578rm5 192 20 : : : cord-011310-fm578rm5 192 21 1 1 LS cord-011310-fm578rm5 192 22 ) ) -RRB- cord-011310-fm578rm5 192 23 cost cost NN cord-011310-fm578rm5 192 24 of of IN cord-011310-fm578rm5 192 25 the the DT cord-011310-fm578rm5 192 26 resistance resistance NN cord-011310-fm578rm5 192 27 and and CC cord-011310-fm578rm5 192 28 2 2 LS cord-011310-fm578rm5 192 29 ) ) -RRB- cord-011310-fm578rm5 192 30 cost cost NN cord-011310-fm578rm5 192 31 - - HYPH cord-011310-fm578rm5 192 32 effectiveness effectiveness NN cord-011310-fm578rm5 192 33 of of IN cord-011310-fm578rm5 192 34 interventions intervention NNS cord-011310-fm578rm5 192 35 to to TO cord-011310-fm578rm5 192 36 reduce reduce VB cord-011310-fm578rm5 192 37 it -PRON- PRP cord-011310-fm578rm5 192 38 [ [ -LRB- cord-011310-fm578rm5 192 39 91 91 CD cord-011310-fm578rm5 192 40 ] ] -RRB- cord-011310-fm578rm5 192 41 . . . cord-011310-fm578rm5 193 1 There there EX cord-011310-fm578rm5 193 2 is be VBZ cord-011310-fm578rm5 193 3 also also RB cord-011310-fm578rm5 193 4 a a DT cord-011310-fm578rm5 193 5 huge huge JJ cord-011310-fm578rm5 193 6 range range NN cord-011310-fm578rm5 193 7 in in IN cord-011310-fm578rm5 193 8 the the DT cord-011310-fm578rm5 193 9 estimates estimate NNS cord-011310-fm578rm5 193 10 of of IN cord-011310-fm578rm5 193 11 additional additional JJ cord-011310-fm578rm5 193 12 cost cost NN cord-011310-fm578rm5 193 13 , , , cord-011310-fm578rm5 193 14 varying vary VBG cord-011310-fm578rm5 193 15 from from IN cord-011310-fm578rm5 193 16 < < XX cord-011310-fm578rm5 193 17 $ $ $ cord-011310-fm578rm5 193 18 5 5 CD cord-011310-fm578rm5 193 19 to to IN cord-011310-fm578rm5 193 20 > > XX cord-011310-fm578rm5 193 21 $ $ $ cord-011310-fm578rm5 193 22 55,000 55,000 CD cord-011310-fm578rm5 193 23 per per IN cord-011310-fm578rm5 193 24 patient patient JJ cord-011310-fm578rm5 193 25 episode episode NN cord-011310-fm578rm5 193 26 [ [ -LRB- cord-011310-fm578rm5 193 27 91 91 CD cord-011310-fm578rm5 193 28 ] ] -RRB- cord-011310-fm578rm5 193 29 . . . cord-011310-fm578rm5 194 1 However however RB cord-011310-fm578rm5 194 2 , , , cord-011310-fm578rm5 194 3 generally generally RB cord-011310-fm578rm5 194 4 the the DT cord-011310-fm578rm5 194 5 current current JJ cord-011310-fm578rm5 194 6 costings costing NNS cord-011310-fm578rm5 194 7 could could MD cord-011310-fm578rm5 194 8 be be VB cord-011310-fm578rm5 194 9 an an DT cord-011310-fm578rm5 194 10 underestimated underestimated JJ cord-011310-fm578rm5 194 11 , , , cord-011310-fm578rm5 194 12 and and CC cord-011310-fm578rm5 194 13 therefore therefore RB cord-011310-fm578rm5 194 14 , , , cord-011310-fm578rm5 194 15 interventions intervention NNS cord-011310-fm578rm5 194 16 in in IN cord-011310-fm578rm5 194 17 using use VBG cord-011310-fm578rm5 194 18 antibiotics antibiotic NNS cord-011310-fm578rm5 194 19 on on IN cord-011310-fm578rm5 194 20 a a DT cord-011310-fm578rm5 194 21 wide wide JJ cord-011310-fm578rm5 194 22 - - HYPH cord-011310-fm578rm5 194 23 scale scale NN cord-011310-fm578rm5 194 24 could could MD cord-011310-fm578rm5 194 25 reflect reflect VB cord-011310-fm578rm5 194 26 as as IN cord-011310-fm578rm5 194 27 highly highly RB cord-011310-fm578rm5 194 28 cost cost NN cord-011310-fm578rm5 194 29 - - HYPH cord-011310-fm578rm5 194 30 saving save VBG cord-011310-fm578rm5 194 31 benefit benefit NN cord-011310-fm578rm5 194 32 . . . cord-011310-fm578rm5 195 1 The the DT cord-011310-fm578rm5 195 2 hidden hidden JJ cord-011310-fm578rm5 195 3 costs cost NNS cord-011310-fm578rm5 195 4 of of IN cord-011310-fm578rm5 195 5 antibiotic antibiotic JJ cord-011310-fm578rm5 195 6 resistance resistance NN cord-011310-fm578rm5 195 7 in in IN cord-011310-fm578rm5 195 8 the the DT cord-011310-fm578rm5 195 9 United United NNP cord-011310-fm578rm5 195 10 States States NNP cord-011310-fm578rm5 195 11 have have VBP cord-011310-fm578rm5 195 12 recently recently RB cord-011310-fm578rm5 195 13 been be VBN cord-011310-fm578rm5 195 14 estimated estimate VBN cord-011310-fm578rm5 195 15 by by IN cord-011310-fm578rm5 195 16 Michaelidis Michaelidis NNP cord-011310-fm578rm5 195 17 et et NNP cord-011310-fm578rm5 195 18 al al NNP cord-011310-fm578rm5 195 19 . . . cord-011310-fm578rm5 196 1 [ [ -LRB- cord-011310-fm578rm5 196 2 92 92 CD cord-011310-fm578rm5 196 3 ] ] -RRB- cord-011310-fm578rm5 196 4 who who WP cord-011310-fm578rm5 196 5 considered consider VBD cord-011310-fm578rm5 196 6 : : : cord-011310-fm578rm5 196 7 ( ( -LRB- cord-011310-fm578rm5 196 8 1 1 LS cord-011310-fm578rm5 196 9 ) ) -RRB- cord-011310-fm578rm5 196 10 hospitalization hospitalization NN cord-011310-fm578rm5 196 11 costs cost NNS cord-011310-fm578rm5 196 12 ; ; , cord-011310-fm578rm5 196 13 ( ( -LRB- cord-011310-fm578rm5 196 14 2 2 LS cord-011310-fm578rm5 196 15 ) ) -RRB- cord-011310-fm578rm5 196 16 secondline secondline JJ cord-011310-fm578rm5 196 17 inpatient inpatient JJ cord-011310-fm578rm5 196 18 antibiotic antibiotic JJ cord-011310-fm578rm5 196 19 costs cost NNS cord-011310-fm578rm5 196 20 ; ; , cord-011310-fm578rm5 196 21 ( ( -LRB- cord-011310-fm578rm5 196 22 3 3 LS cord-011310-fm578rm5 196 23 ) ) -RRB- cord-011310-fm578rm5 196 24 second second JJ cord-011310-fm578rm5 196 25 - - HYPH cord-011310-fm578rm5 196 26 line line NN cord-011310-fm578rm5 196 27 out out IN cord-011310-fm578rm5 196 28 - - HYPH cord-011310-fm578rm5 196 29 patient patient NN cord-011310-fm578rm5 196 30 antibiotic antibiotic JJ cord-011310-fm578rm5 196 31 costs cost NNS cord-011310-fm578rm5 196 32 , , , cord-011310-fm578rm5 196 33 and and CC cord-011310-fm578rm5 196 34 ( ( -LRB- cord-011310-fm578rm5 196 35 4 4 LS cord-011310-fm578rm5 196 36 ) ) -RRB- cord-011310-fm578rm5 196 37 antibiotic antibiotic JJ cord-011310-fm578rm5 196 38 stewardship stewardship NN cord-011310-fm578rm5 196 39 costs cost NNS cord-011310-fm578rm5 196 40 . . . cord-011310-fm578rm5 197 1 The the DT cord-011310-fm578rm5 197 2 authors author NNS cord-011310-fm578rm5 197 3 estimated estimate VBD cord-011310-fm578rm5 197 4 that that IN cord-011310-fm578rm5 197 5 the the DT cord-011310-fm578rm5 197 6 total total JJ cord-011310-fm578rm5 197 7 hidden hide VBN cord-011310-fm578rm5 197 8 cost cost NN cord-011310-fm578rm5 197 9 attributable attributable JJ cord-011310-fm578rm5 197 10 to to IN cord-011310-fm578rm5 197 11 each each DT cord-011310-fm578rm5 197 12 ambulatory ambulatory JJ cord-011310-fm578rm5 197 13 antibiotic antibiotic JJ cord-011310-fm578rm5 197 14 prescription prescription NN cord-011310-fm578rm5 197 15 was be VBD cord-011310-fm578rm5 197 16 $ $ $ cord-011310-fm578rm5 197 17 13 13 CD cord-011310-fm578rm5 197 18 ( ( -LRB- cord-011310-fm578rm5 197 19 range range NN cord-011310-fm578rm5 197 20 : : : cord-011310-fm578rm5 197 21 $ $ $ cord-011310-fm578rm5 197 22 3 3 CD cord-011310-fm578rm5 197 23 - - SYM cord-011310-fm578rm5 197 24 95 95 CD cord-011310-fm578rm5 197 25 ) ) -RRB- cord-011310-fm578rm5 197 26 , , , cord-011310-fm578rm5 197 27 and and CC cord-011310-fm578rm5 197 28 each each DT cord-011310-fm578rm5 197 29 ambulatory ambulatory JJ cord-011310-fm578rm5 197 30 antibiotic antibiotic JJ cord-011310-fm578rm5 197 31 prescription prescription NN cord-011310-fm578rm5 197 32 would would MD cord-011310-fm578rm5 197 33 increase increase VB cord-011310-fm578rm5 197 34 antibiotic antibiotic JJ cord-011310-fm578rm5 197 35 costs cost NNS cord-011310-fm578rm5 197 36 by by IN cord-011310-fm578rm5 197 37 65 65 CD cord-011310-fm578rm5 197 38 % % NN cord-011310-fm578rm5 197 39 ( ( -LRB- cord-011310-fm578rm5 197 40 range range NN cord-011310-fm578rm5 197 41 : : : cord-011310-fm578rm5 197 42 15 15 CD cord-011310-fm578rm5 197 43 - - SYM cord-011310-fm578rm5 197 44 475 475 CD cord-011310-fm578rm5 197 45 % % NN cord-011310-fm578rm5 197 46 ) ) -RRB- cord-011310-fm578rm5 197 47 , , , cord-011310-fm578rm5 197 48 if if IN cord-011310-fm578rm5 197 49 the the DT cord-011310-fm578rm5 197 50 cost cost NN cord-011310-fm578rm5 197 51 of of IN cord-011310-fm578rm5 197 52 the the DT cord-011310-fm578rm5 197 53 resistance resistance NN cord-011310-fm578rm5 197 54 was be VBD cord-011310-fm578rm5 197 55 incorporated incorporate VBN cord-011310-fm578rm5 197 56 into into IN cord-011310-fm578rm5 197 57 antibiotic antibiotic JJ cord-011310-fm578rm5 197 58 costs cost NNS cord-011310-fm578rm5 197 59 paid pay VBN cord-011310-fm578rm5 197 60 by by IN cord-011310-fm578rm5 197 61 patients patient NNS cord-011310-fm578rm5 197 62 or or CC cord-011310-fm578rm5 197 63 payers payer NNS cord-011310-fm578rm5 197 64 [ [ -LRB- cord-011310-fm578rm5 197 65 92 92 CD cord-011310-fm578rm5 197 66 ] ] -RRB- cord-011310-fm578rm5 197 67 . . . cord-011310-fm578rm5 198 1 Applying apply VBG cord-011310-fm578rm5 198 2 this this DT cord-011310-fm578rm5 198 3 estimate estimate NN cord-011310-fm578rm5 198 4 to to IN cord-011310-fm578rm5 198 5 the the DT cord-011310-fm578rm5 198 6 cost cost NN cord-011310-fm578rm5 198 7 - - HYPH cord-011310-fm578rm5 198 8 effectiveness effectiveness NN cord-011310-fm578rm5 198 9 estimates estimate NNS cord-011310-fm578rm5 198 10 of of IN cord-011310-fm578rm5 198 11 H. h. NN cord-011310-fm578rm5 198 12 pylori pylori NN cord-011310-fm578rm5 198 13 eradication eradication NN cord-011310-fm578rm5 198 14 and and CC cord-011310-fm578rm5 198 15 modelling model VBG cord-011310-fm578rm5 198 16 the the DT cord-011310-fm578rm5 198 17 costs cost NNS cord-011310-fm578rm5 198 18 of of IN cord-011310-fm578rm5 198 19 resistome resistome VBN cord-011310-fm578rm5 198 20 for for IN cord-011310-fm578rm5 198 21 other other JJ cord-011310-fm578rm5 198 22 countries country NNS cord-011310-fm578rm5 198 23 globally globally RB cord-011310-fm578rm5 198 24 probably probably RB cord-011310-fm578rm5 198 25 would would MD cord-011310-fm578rm5 198 26 change change VB cord-011310-fm578rm5 198 27 the the DT cord-011310-fm578rm5 198 28 very very RB cord-011310-fm578rm5 198 29 beneficial beneficial JJ cord-011310-fm578rm5 198 30 cost cost NN cord-011310-fm578rm5 198 31 - - HYPH cord-011310-fm578rm5 198 32 effectiveness effectiveness NN cord-011310-fm578rm5 198 33 picture picture NN cord-011310-fm578rm5 198 34 of of IN cord-011310-fm578rm5 198 35 screen screen NN cord-011310-fm578rm5 198 36 - - HYPH cord-011310-fm578rm5 198 37 and and CC cord-011310-fm578rm5 198 38 - - HYPH cord-011310-fm578rm5 198 39 treat treat VB cord-011310-fm578rm5 198 40 strategy strategy NN cord-011310-fm578rm5 198 41 . . . cord-011310-fm578rm5 199 1 The the DT cord-011310-fm578rm5 199 2 cost cost NN cord-011310-fm578rm5 199 3 - - HYPH cord-011310-fm578rm5 199 4 effectiveness effectiveness NN cord-011310-fm578rm5 199 5 estimates estimate NNS cord-011310-fm578rm5 199 6 should should MD cord-011310-fm578rm5 199 7 also also RB cord-011310-fm578rm5 199 8 incorporate incorporate VB cord-011310-fm578rm5 199 9 those those DT cord-011310-fm578rm5 199 10 of of IN cord-011310-fm578rm5 199 11 organizing organize VBG cord-011310-fm578rm5 199 12 the the DT cord-011310-fm578rm5 199 13 activities activity NNS cord-011310-fm578rm5 199 14 and and CC cord-011310-fm578rm5 199 15 governance governance NN cord-011310-fm578rm5 199 16 of of IN cord-011310-fm578rm5 199 17 the the DT cord-011310-fm578rm5 199 18 process process NN cord-011310-fm578rm5 199 19 , , , cord-011310-fm578rm5 199 20 exactly exactly RB cord-011310-fm578rm5 199 21 as as IN cord-011310-fm578rm5 199 22 in in IN cord-011310-fm578rm5 199 23 traditional traditional JJ cord-011310-fm578rm5 199 24 cancer cancer NN cord-011310-fm578rm5 199 25 screening screening NN cord-011310-fm578rm5 199 26 program program NN cord-011310-fm578rm5 199 27 settings setting NNS cord-011310-fm578rm5 199 28 [ [ -LRB- cord-011310-fm578rm5 199 29 93 93 CD cord-011310-fm578rm5 199 30 ] ] -RRB- cord-011310-fm578rm5 199 31 . . . cord-011310-fm578rm5 200 1 Finally finally RB cord-011310-fm578rm5 200 2 , , , cord-011310-fm578rm5 200 3 compliance compliance NN cord-011310-fm578rm5 200 4 rates rate NNS cord-011310-fm578rm5 200 5 of of IN cord-011310-fm578rm5 200 6 the the DT cord-011310-fm578rm5 200 7 target target NN cord-011310-fm578rm5 200 8 population population NN cord-011310-fm578rm5 200 9 , , , cord-011310-fm578rm5 200 10 equal equal JJ cord-011310-fm578rm5 200 11 participation participation NN cord-011310-fm578rm5 200 12 of of IN cord-011310-fm578rm5 200 13 both both DT cord-011310-fm578rm5 200 14 genders gender NNS cord-011310-fm578rm5 200 15 and and CC cord-011310-fm578rm5 200 16 coverage coverage NN cord-011310-fm578rm5 200 17 of of IN cord-011310-fm578rm5 200 18 the the DT cord-011310-fm578rm5 200 19 lower low JJR cord-011310-fm578rm5 200 20 socioeconomic socioeconomic JJ cord-011310-fm578rm5 200 21 class class NN cord-011310-fm578rm5 200 22 members member NNS cord-011310-fm578rm5 200 23 is be VBZ cord-011310-fm578rm5 200 24 critical critical JJ cord-011310-fm578rm5 200 25 for for IN cord-011310-fm578rm5 200 26 the the DT cord-011310-fm578rm5 200 27 success success NN cord-011310-fm578rm5 200 28 for for IN cord-011310-fm578rm5 200 29 any any DT cord-011310-fm578rm5 200 30 preventive preventive JJ cord-011310-fm578rm5 200 31 strategy strategy NN cord-011310-fm578rm5 200 32 , , , cord-011310-fm578rm5 200 33 and and CC cord-011310-fm578rm5 200 34 should should MD cord-011310-fm578rm5 200 35 be be VB cord-011310-fm578rm5 200 36 considered consider VBN cord-011310-fm578rm5 200 37 in in IN cord-011310-fm578rm5 200 38 cost cost NN cord-011310-fm578rm5 200 39 - - HYPH cord-011310-fm578rm5 200 40 effectiveness effectiveness NN cord-011310-fm578rm5 200 41 modelling modelling NN cord-011310-fm578rm5 200 42 . . . cord-011310-fm578rm5 201 1 Because because IN cord-011310-fm578rm5 201 2 of of IN cord-011310-fm578rm5 201 3 the the DT cord-011310-fm578rm5 201 4 necessity necessity NN cord-011310-fm578rm5 201 5 of of IN cord-011310-fm578rm5 201 6 antibiotic antibiotic JJ cord-011310-fm578rm5 201 7 use use NN cord-011310-fm578rm5 201 8 and and CC cord-011310-fm578rm5 201 9 potential potential JJ cord-011310-fm578rm5 201 10 adverse adverse JJ cord-011310-fm578rm5 201 11 events event NNS cord-011310-fm578rm5 201 12 , , , cord-011310-fm578rm5 201 13 participation participation NN cord-011310-fm578rm5 201 14 rates rate NNS cord-011310-fm578rm5 201 15 could could MD cord-011310-fm578rm5 201 16 be be VB cord-011310-fm578rm5 201 17 lower low JJR cord-011310-fm578rm5 201 18 for for IN cord-011310-fm578rm5 201 19 an an DT cord-011310-fm578rm5 201 20 H. h. NN cord-011310-fm578rm5 201 21 pylori pylori NN cord-011310-fm578rm5 201 22 screen screen NN cord-011310-fm578rm5 201 23 - - HYPH cord-011310-fm578rm5 201 24 and and CC cord-011310-fm578rm5 201 25 - - HYPH cord-011310-fm578rm5 201 26 treat treat VB cord-011310-fm578rm5 201 27 strategy strategy NN cord-011310-fm578rm5 201 28 than than IN cord-011310-fm578rm5 201 29 for for IN cord-011310-fm578rm5 201 30 traditional traditional JJ cord-011310-fm578rm5 201 31 screening screening NN cord-011310-fm578rm5 201 32 approaches approach NNS cord-011310-fm578rm5 201 33 . . . cord-011310-fm578rm5 202 1 This this DT cord-011310-fm578rm5 202 2 has have VBZ cord-011310-fm578rm5 202 3 been be VBN cord-011310-fm578rm5 202 4 suggested suggest VBN cord-011310-fm578rm5 202 5 by by IN cord-011310-fm578rm5 202 6 the the DT cord-011310-fm578rm5 202 7 participation participation NN cord-011310-fm578rm5 202 8 results result NNS cord-011310-fm578rm5 202 9 in in IN cord-011310-fm578rm5 202 10 the the DT cord-011310-fm578rm5 202 11 Danish danish JJ cord-011310-fm578rm5 202 12 community community NN cord-011310-fm578rm5 202 13 H. h. NN cord-011310-fm578rm5 202 14 pylori pylori NN cord-011310-fm578rm5 202 15 screening screening NN cord-011310-fm578rm5 202 16 trial trial NN cord-011310-fm578rm5 202 17 [ [ -LRB- cord-011310-fm578rm5 202 18 94 94 CD cord-011310-fm578rm5 202 19 ] ] -RRB- cord-011310-fm578rm5 203 1 and and CC cord-011310-fm578rm5 203 2 is be VBZ cord-011310-fm578rm5 203 3 currently currently RB cord-011310-fm578rm5 203 4 being be VBG cord-011310-fm578rm5 203 5 addressed address VBN cord-011310-fm578rm5 203 6 in in IN cord-011310-fm578rm5 203 7 the the DT cord-011310-fm578rm5 203 8 GISTAR GISTAR NNP cord-011310-fm578rm5 203 9 cohort cohort NN cord-011310-fm578rm5 203 10 in in IN cord-011310-fm578rm5 203 11 Latvia Latvia NNP cord-011310-fm578rm5 203 12 [ [ -LRB- cord-011310-fm578rm5 203 13 95 95 CD cord-011310-fm578rm5 203 14 ] ] -RRB- cord-011310-fm578rm5 203 15 . . . cord-011310-fm578rm5 204 1 The the DT cord-011310-fm578rm5 204 2 Screen screen NN cord-011310-fm578rm5 204 3 - - HYPH cord-011310-fm578rm5 204 4 and and CC cord-011310-fm578rm5 204 5 - - HYPH cord-011310-fm578rm5 204 6 treat treat VB cord-011310-fm578rm5 204 7 strategy strategy NN cord-011310-fm578rm5 204 8 clearly clearly RB cord-011310-fm578rm5 204 9 increases increase VBZ cord-011310-fm578rm5 204 10 the the DT cord-011310-fm578rm5 204 11 consumption consumption NN cord-011310-fm578rm5 204 12 of of IN cord-011310-fm578rm5 204 13 antibiotics antibiotic NNS cord-011310-fm578rm5 204 14 on on IN cord-011310-fm578rm5 204 15 a a DT cord-011310-fm578rm5 204 16 population population NN cord-011310-fm578rm5 204 17 level level NN cord-011310-fm578rm5 204 18 . . . cord-011310-fm578rm5 205 1 In in IN cord-011310-fm578rm5 205 2 avoiding avoid VBG cord-011310-fm578rm5 205 3 the the DT cord-011310-fm578rm5 205 4 problems problem NNS cord-011310-fm578rm5 205 5 of of IN cord-011310-fm578rm5 205 6 treating treat VBG cord-011310-fm578rm5 205 7 life life NN cord-011310-fm578rm5 205 8 - - HYPH cord-011310-fm578rm5 205 9 threatening threaten VBG cord-011310-fm578rm5 205 10 diseases disease NNS cord-011310-fm578rm5 205 11 due due JJ cord-011310-fm578rm5 205 12 to to IN cord-011310-fm578rm5 205 13 increased increase VBN cord-011310-fm578rm5 205 14 resistome resistome NNP cord-011310-fm578rm5 205 15 , , , cord-011310-fm578rm5 205 16 antibiotics antibiotic NNS cord-011310-fm578rm5 205 17 with with IN cord-011310-fm578rm5 205 18 high high JJ cord-011310-fm578rm5 205 19 potential potential NN cord-011310-fm578rm5 205 20 for for IN cord-011310-fm578rm5 205 21 resistome resistome JJ cord-011310-fm578rm5 205 22 induction induction NN cord-011310-fm578rm5 205 23 , , , cord-011310-fm578rm5 205 24 and and CC cord-011310-fm578rm5 205 25 use use VB cord-011310-fm578rm5 205 26 for for IN cord-011310-fm578rm5 205 27 treating treat VBG cord-011310-fm578rm5 205 28 life life NN cord-011310-fm578rm5 205 29 - - HYPH cord-011310-fm578rm5 205 30 threatening threaten VBG cord-011310-fm578rm5 205 31 diseases disease NNS cord-011310-fm578rm5 205 32 ( ( -LRB- cord-011310-fm578rm5 205 33 such such JJ cord-011310-fm578rm5 205 34 as as IN cord-011310-fm578rm5 205 35 macrolides macrolide NNS cord-011310-fm578rm5 205 36 ) ) -RRB- cord-011310-fm578rm5 205 37 should should MD cord-011310-fm578rm5 205 38 be be VB cord-011310-fm578rm5 205 39 avoided avoid VBN cord-011310-fm578rm5 205 40 in in IN cord-011310-fm578rm5 205 41 populationbased populationbased JJ cord-011310-fm578rm5 205 42 H. H. NNP cord-011310-fm578rm5 205 43 pylori pylori NN cord-011310-fm578rm5 205 44 eradication eradication NN cord-011310-fm578rm5 205 45 regimens regimen NNS cord-011310-fm578rm5 205 46 for for IN cord-011310-fm578rm5 205 47 otherwise otherwise RB cord-011310-fm578rm5 205 48 healthy healthy JJ cord-011310-fm578rm5 205 49 people people NNS cord-011310-fm578rm5 205 50 . . . cord-011310-fm578rm5 206 1 Narrowing narrow VBG cord-011310-fm578rm5 206 2 of of IN cord-011310-fm578rm5 206 3 the the DT cord-011310-fm578rm5 206 4 target target NN cord-011310-fm578rm5 206 5 groups group NNS cord-011310-fm578rm5 206 6 for for IN cord-011310-fm578rm5 206 7 the the DT cord-011310-fm578rm5 206 8 screen screen NN cord-011310-fm578rm5 206 9 - - HYPH cord-011310-fm578rm5 206 10 andtreat andtreat NN cord-011310-fm578rm5 206 11 strategy strategy NN cord-011310-fm578rm5 206 12 is be VBZ cord-011310-fm578rm5 206 13 desirable desirable JJ cord-011310-fm578rm5 206 14 , , , cord-011310-fm578rm5 206 15 e.g. e.g. RB cord-011310-fm578rm5 206 16 for for IN cord-011310-fm578rm5 206 17 young young JJ cord-011310-fm578rm5 206 18 people people NNS cord-011310-fm578rm5 206 19 before before IN cord-011310-fm578rm5 206 20 family family NN cord-011310-fm578rm5 206 21 planning planning NN cord-011310-fm578rm5 206 22 and and CC cord-011310-fm578rm5 206 23 potential potential JJ cord-011310-fm578rm5 206 24 transmission transmission NN cord-011310-fm578rm5 206 25 of of IN cord-011310-fm578rm5 206 26 H. h. NN cord-011310-fm578rm5 206 27 pylori pylori NN cord-011310-fm578rm5 206 28 to to IN cord-011310-fm578rm5 206 29 their -PRON- PRP$ cord-011310-fm578rm5 206 30 offspring offspring NN cord-011310-fm578rm5 206 31 . . . cord-011310-fm578rm5 207 1 Finally finally RB cord-011310-fm578rm5 207 2 , , , cord-011310-fm578rm5 207 3 in in IN cord-011310-fm578rm5 207 4 implementing implement VBG cord-011310-fm578rm5 207 5 any any DT cord-011310-fm578rm5 207 6 screen screen NN cord-011310-fm578rm5 207 7 - - HYPH cord-011310-fm578rm5 207 8 and and CC cord-011310-fm578rm5 207 9 - - HYPH cord-011310-fm578rm5 207 10 treat treat VB cord-011310-fm578rm5 207 11 strategy strategy NN cord-011310-fm578rm5 207 12 , , , cord-011310-fm578rm5 207 13 this this DT cord-011310-fm578rm5 207 14 should should MD cord-011310-fm578rm5 207 15 be be VB cord-011310-fm578rm5 207 16 done do VBN cord-011310-fm578rm5 207 17 under under IN cord-011310-fm578rm5 207 18 thorough thorough JJ cord-011310-fm578rm5 207 19 surveillance surveillance NN cord-011310-fm578rm5 207 20 corresponding correspond VBG cord-011310-fm578rm5 207 21 to to IN cord-011310-fm578rm5 207 22 the the DT cord-011310-fm578rm5 207 23 general general JJ cord-011310-fm578rm5 207 24 principles principle NNS cord-011310-fm578rm5 207 25 of of IN cord-011310-fm578rm5 207 26 screening screening NN cord-011310-fm578rm5 207 27 governance governance NN cord-011310-fm578rm5 207 28 , , , cord-011310-fm578rm5 207 29 including include VBG cord-011310-fm578rm5 207 30 surveillance surveillance NN cord-011310-fm578rm5 207 31 of of IN cord-011310-fm578rm5 207 32 the the DT cord-011310-fm578rm5 207 33 incidence incidence NN cord-011310-fm578rm5 207 34 of of IN cord-011310-fm578rm5 207 35 serious serious JJ cord-011310-fm578rm5 207 36 infections infection NNS cord-011310-fm578rm5 207 37 and and CC cord-011310-fm578rm5 207 38 all all DT cord-011310-fm578rm5 207 39 - - HYPH cord-011310-fm578rm5 207 40 cause cause NN cord-011310-fm578rm5 207 41 mortality mortality NN cord-011310-fm578rm5 207 42 . . . cord-011310-fm578rm5 208 1 fr/ fr/ JJ cord-011310-fm578rm5 209 1 Book book NN cord-011310-fm578rm5 209 2 - - HYPH cord-011310-fm578rm5 209 3 And and CC cord-011310-fm578rm5 209 4 - - HYPH cord-011310-fm578rm5 209 5 Repor Repor NNP cord-011310-fm578rm5 209 6 t t NN cord-011310-fm578rm5 209 7 - - HYPH cord-011310-fm578rm5 209 8 Serie Serie NNP cord-011310-fm578rm5 209 9 s s NNP cord-011310-fm578rm5 209 10 / / SYM cord-011310-fm578rm5 209 11 Iarc Iarc NNP cord-011310-fm578rm5 210 1 -Worki -Worki : cord-011310-fm578rm5 210 2 ng ng NNP cord-011310-fm578rm5 210 3 - - HYPH cord-011310-fm578rm5 210 4 Group Group NNP cord-011310-fm578rm5 211 1 -Repor -Repor NNP cord-011310-fm578rm5 211 2 ts/-Em ts/-Em NNP cord-011310-fm578rm5 211 3 - - HYPH cord-011310-fm578rm5 211 4 Helic Helic NNP cord-011310-fm578rm5 211 5 obact obact NN cord-011310-fm578rm5 211 6 er er JJ cord-011310-fm578rm5 211 7 - - HYPH cord-011310-fm578rm5 211 8 Pylor Pylor NNP cord-011310-fm578rm5 211 9 i i NNP cord-011310-fm578rm5 211 10 - - HYPH cord-011310-fm578rm5 211 11 Em Em NNP cord-011310-fm578rm5 211 12 - - HYPH cord-011310-fm578rm5 211 13 Eradi Eradi NNP cord-011310-fm578rm5 212 1 catio catio NNP cord-011310-fm578rm5 212 2 n n NNP cord-011310-fm578rm5 212 3 - - HYPH cord-011310-fm578rm5 212 4 As as IN cord-011310-fm578rm5 212 5 - - HYPH cord-011310-fm578rm5 212 6 A A NNP cord-011310-fm578rm5 212 7 - - HYPH cord-011310-fm578rm5 212 8 Strat Strat NNP cord-011310-fm578rm5 212 9 egy egy NNP cord-011310-fm578rm5 212 10 - - HYPH cord-011310-fm578rm5 212 11 For for IN cord-011310-fm578rm5 212 12 - - HYPH cord-011310-fm578rm5 212 13 Preve Preve NNP cord-011310-fm578rm5 212 14 nting nting NN cord-011310-fm578rm5 212 15 -Gastr -gastr NN cord-011310-fm578rm5 212 16 ic ic NNP cord-011310-fm578rm5 212 17 - - HYPH cord-011310-fm578rm5 212 18 Cance Cance NNP cord-011310-fm578rm5 212 19 r-2014 r-2014 VBZ cord-011310-fm578rm5 212 20 Global global JJ cord-011310-fm578rm5 212 21 cancer cancer NN cord-011310-fm578rm5 212 22 statistics statistic NNS cord-011310-fm578rm5 212 23 2018 2018 CD cord-011310-fm578rm5 212 24 : : : cord-011310-fm578rm5 213 1 GLOBOCAN GLOBOCAN NNP cord-011310-fm578rm5 213 2 estimates estimate VBZ cord-011310-fm578rm5 213 3 of of IN cord-011310-fm578rm5 213 4 incidence incidence NN cord-011310-fm578rm5 213 5 and and CC cord-011310-fm578rm5 213 6 mortality mortality NN cord-011310-fm578rm5 213 7 worldwide worldwide RB cord-011310-fm578rm5 213 8 for for IN cord-011310-fm578rm5 213 9 36 36 CD cord-011310-fm578rm5 213 10 cancers cancer NNS cord-011310-fm578rm5 213 11 in in IN cord-011310-fm578rm5 213 12 185 185 CD cord-011310-fm578rm5 213 13 countries country NNS cord-011310-fm578rm5 213 14 fr fr NNP cord-011310-fm578rm5 213 15 / / SYM cord-011310-fm578rm5 213 16 Book Book NNP cord-011310-fm578rm5 213 17 - - HYPH cord-011310-fm578rm5 213 18 And and CC cord-011310-fm578rm5 213 19 - - HYPH cord-011310-fm578rm5 213 20 Repor Repor NNP cord-011310-fm578rm5 214 1 t- t- XX cord-011310-fm578rm5 215 1 Serie Serie NNP cord-011310-fm578rm5 215 2 s s NNP cord-011310-fm578rm5 215 3 / / SYM cord-011310-fm578rm5 215 4 Iarc Iarc NNP cord-011310-fm578rm5 216 1 -Worki -Worki : cord-011310-fm578rm5 216 2 ng ng NNP cord-011310-fm578rm5 216 3 - - HYPH cord-011310-fm578rm5 216 4 Group Group NNP cord-011310-fm578rm5 217 1 -Repor -Repor NNP cord-011310-fm578rm5 217 2 ts/-Em ts/-Em NNP cord-011310-fm578rm5 217 3 - - HYPH cord-011310-fm578rm5 217 4 Helic Helic NNP cord-011310-fm578rm5 217 5 obact obact NN cord-011310-fm578rm5 217 6 er er JJ cord-011310-fm578rm5 217 7 - - HYPH cord-011310-fm578rm5 217 8 Pylor Pylor NNP cord-011310-fm578rm5 217 9 i i NNP cord-011310-fm578rm5 217 10 - - HYPH cord-011310-fm578rm5 217 11 Em Em NNP cord-011310-fm578rm5 217 12 - - HYPH cord-011310-fm578rm5 217 13 Eradi Eradi NNP cord-011310-fm578rm5 218 1 catio catio NNP cord-011310-fm578rm5 218 2 n n NNP cord-011310-fm578rm5 218 3 - - HYPH cord-011310-fm578rm5 218 4 As as IN cord-011310-fm578rm5 218 5 - - HYPH cord-011310-fm578rm5 218 6 A A NNP cord-011310-fm578rm5 218 7 - - HYPH cord-011310-fm578rm5 218 8 Strat Strat NNP cord-011310-fm578rm5 218 9 egy egy NNP cord-011310-fm578rm5 218 10 - - HYPH cord-011310-fm578rm5 218 11 For for IN cord-011310-fm578rm5 218 12 - - HYPH cord-011310-fm578rm5 218 13 Preve Preve NNP cord-011310-fm578rm5 218 14 nting nting NN cord-011310-fm578rm5 218 15 -Gastr -gastr NN cord-011310-fm578rm5 218 16 ic ic NNP cord-011310-fm578rm5 218 17 - - HYPH cord-011310-fm578rm5 218 18 Cance Cance NNP cord-011310-fm578rm5 218 19 r-2014 r-2014 VBZ cord-011310-fm578rm5 218 20 Global global JJ cord-011310-fm578rm5 218 21 burden burden NN cord-011310-fm578rm5 218 22 of of IN cord-011310-fm578rm5 218 23 cancers cancer NNS cord-011310-fm578rm5 218 24 attributable attributable JJ cord-011310-fm578rm5 218 25 to to IN cord-011310-fm578rm5 218 26 infections infection NNS cord-011310-fm578rm5 218 27 in in IN cord-011310-fm578rm5 218 28 2012 2012 CD cord-011310-fm578rm5 218 29 : : : cord-011310-fm578rm5 218 30 a a DT cord-011310-fm578rm5 218 31 synthetic synthetic JJ cord-011310-fm578rm5 218 32 analysis analysis NN cord-011310-fm578rm5 218 33 Global global JJ cord-011310-fm578rm5 218 34 burden burden NN cord-011310-fm578rm5 218 35 of of IN cord-011310-fm578rm5 218 36 gastric gastric JJ cord-011310-fm578rm5 218 37 cancer cancer NN cord-011310-fm578rm5 218 38 attributable attributable JJ cord-011310-fm578rm5 218 39 to to IN cord-011310-fm578rm5 218 40 Helicobacter Helicobacter NNP cord-011310-fm578rm5 218 41 pylori pylori NN cord-011310-fm578rm5 218 42 Review Review NNP cord-011310-fm578rm5 218 43 article article NN cord-011310-fm578rm5 218 44 : : : cord-011310-fm578rm5 218 45 exploring explore VBG cord-011310-fm578rm5 218 46 the the DT cord-011310-fm578rm5 218 47 link link NN cord-011310-fm578rm5 218 48 between between IN cord-011310-fm578rm5 218 49 Helicobacter Helicobacter NNP cord-011310-fm578rm5 218 50 pylori pylori NN cord-011310-fm578rm5 218 51 and and CC cord-011310-fm578rm5 218 52 gastric gastric JJ cord-011310-fm578rm5 218 53 cancer cancer NN cord-011310-fm578rm5 218 54 Review Review NNP cord-011310-fm578rm5 218 55 article article NN cord-011310-fm578rm5 219 1 : : : cord-011310-fm578rm5 219 2 Helicobacter helicobacter NN cord-011310-fm578rm5 219 3 pylori pylori NN cord-011310-fm578rm5 219 4 eradication eradication NN cord-011310-fm578rm5 219 5 for for IN cord-011310-fm578rm5 219 6 the the DT cord-011310-fm578rm5 219 7 prevention prevention NN cord-011310-fm578rm5 219 8 of of IN cord-011310-fm578rm5 219 9 gastric gastric JJ cord-011310-fm578rm5 219 10 cancer cancer NN cord-011310-fm578rm5 219 11 Management management NN cord-011310-fm578rm5 219 12 of of IN cord-011310-fm578rm5 219 13 epithelial epithelial JJ cord-011310-fm578rm5 219 14 precancerous precancerous JJ cord-011310-fm578rm5 219 15 conditions condition NNS cord-011310-fm578rm5 219 16 and and CC cord-011310-fm578rm5 219 17 lesions lesion NNS cord-011310-fm578rm5 219 18 in in IN cord-011310-fm578rm5 219 19 the the DT cord-011310-fm578rm5 219 20 stomach stomach NN cord-011310-fm578rm5 219 21 ( ( -LRB- cord-011310-fm578rm5 219 22 MAPS map NNS cord-011310-fm578rm5 219 23 II ii CD cord-011310-fm578rm5 219 24 ) ) -RRB- cord-011310-fm578rm5 219 25 : : : cord-011310-fm578rm5 219 26 European European NNP cord-011310-fm578rm5 219 27 Society Society NNP cord-011310-fm578rm5 219 28 of of IN cord-011310-fm578rm5 219 29 Gastrointestinal Gastrointestinal NNP cord-011310-fm578rm5 219 30 Endoscopy Endoscopy NNP cord-011310-fm578rm5 219 31 ( ( -LRB- cord-011310-fm578rm5 219 32 ESGE ESGE NNP cord-011310-fm578rm5 219 33 ) ) -RRB- cord-011310-fm578rm5 219 34 , , , cord-011310-fm578rm5 219 35 European European NNP cord-011310-fm578rm5 219 36 Helicobacter Helicobacter NNP cord-011310-fm578rm5 219 37 and and CC cord-011310-fm578rm5 219 38 Microbiota Microbiota NNP cord-011310-fm578rm5 219 39 Study Study NNP cord-011310-fm578rm5 219 40 Group Group NNP cord-011310-fm578rm5 219 41 ( ( -LRB- cord-011310-fm578rm5 219 42 EHMSG EHMSG NNP cord-011310-fm578rm5 219 43 ) ) -RRB- cord-011310-fm578rm5 219 44 , , , cord-011310-fm578rm5 219 45 European European NNP cord-011310-fm578rm5 219 46 Society Society NNP cord-011310-fm578rm5 219 47 of of IN cord-011310-fm578rm5 219 48 Pathology Pathology NNP cord-011310-fm578rm5 219 49 ( ( -LRB- cord-011310-fm578rm5 219 50 ESP ESP NNP cord-011310-fm578rm5 219 51 ) ) -RRB- cord-011310-fm578rm5 219 52 , , , cord-011310-fm578rm5 219 53 and and CC cord-011310-fm578rm5 219 54 Sociedade Sociedade NNP cord-011310-fm578rm5 219 55 Portuguesa Portuguesa NNP cord-011310-fm578rm5 219 56 de de NNP cord-011310-fm578rm5 219 57 Endoscopia Endoscopia NNP cord-011310-fm578rm5 219 58 Digestiva Digestiva NNP cord-011310-fm578rm5 219 59 ( ( -LRB- cord-011310-fm578rm5 219 60 SPED sped NN cord-011310-fm578rm5 219 61 ) ) -RRB- cord-011310-fm578rm5 219 62 guideline guideline NN cord-011310-fm578rm5 219 63 update update NN cord-011310-fm578rm5 219 64 2019 2019 CD cord-011310-fm578rm5 220 1 How how WRB cord-011310-fm578rm5 220 2 far far RB cord-011310-fm578rm5 220 3 are be VBP cord-011310-fm578rm5 220 4 we -PRON- PRP cord-011310-fm578rm5 220 5 from from IN cord-011310-fm578rm5 220 6 vaccination vaccination NN cord-011310-fm578rm5 220 7 against against IN cord-011310-fm578rm5 220 8 Helicobacter Helicobacter NNP cord-011310-fm578rm5 220 9 pylori pylori NN cord-011310-fm578rm5 220 10 infection infection NN cord-011310-fm578rm5 220 11 ? ? . cord-011310-fm578rm5 221 1 Reconciliation reconciliation NN cord-011310-fm578rm5 221 2 of of IN cord-011310-fm578rm5 221 3 recent recent JJ cord-011310-fm578rm5 221 4 Helicobacter Helicobacter NNP cord-011310-fm578rm5 221 5 pylori pylori NN cord-011310-fm578rm5 221 6 treatment treatment NN cord-011310-fm578rm5 221 7 guidelines guideline NNS cord-011310-fm578rm5 221 8 in in IN cord-011310-fm578rm5 221 9 a a DT cord-011310-fm578rm5 221 10 time time NN cord-011310-fm578rm5 221 11 of of IN cord-011310-fm578rm5 221 12 increasing increase VBG cord-011310-fm578rm5 221 13 resistance resistance NN cord-011310-fm578rm5 221 14 to to IN cord-011310-fm578rm5 221 15 antibiotics antibiotic NNS cord-011310-fm578rm5 221 16 Management Management NNP cord-011310-fm578rm5 221 17 of of IN cord-011310-fm578rm5 221 18 Helicobacter Helicobacter NNP cord-011310-fm578rm5 221 19 pylori pylori NN cord-011310-fm578rm5 221 20 infection infection NN cord-011310-fm578rm5 221 21 - - : cord-011310-fm578rm5 221 22 the the DT cord-011310-fm578rm5 221 23 Maastricht Maastricht NNP cord-011310-fm578rm5 221 24 V V NNP cord-011310-fm578rm5 221 25 / / SYM cord-011310-fm578rm5 221 26 Florence Florence NNP cord-011310-fm578rm5 221 27 consensus consensus NN cord-011310-fm578rm5 221 28 report report NN cord-011310-fm578rm5 221 29 Cancer Cancer NNP cord-011310-fm578rm5 221 30 screening screening NN cord-011310-fm578rm5 221 31 : : : cord-011310-fm578rm5 221 32 policy policy NN cord-011310-fm578rm5 221 33 recommendations recommendation NNS cord-011310-fm578rm5 221 34 on on IN cord-011310-fm578rm5 221 35 governance governance NN cord-011310-fm578rm5 221 36 , , , cord-011310-fm578rm5 221 37 organization organization NN cord-011310-fm578rm5 221 38 and and CC cord-011310-fm578rm5 221 39 evaluation evaluation NN cord-011310-fm578rm5 221 40 of of IN cord-011310-fm578rm5 221 41 cancer cancer NN cord-011310-fm578rm5 221 42 screening screening NN cord-011310-fm578rm5 222 1 Helicobacter Helicobacter NNP cord-011310-fm578rm5 222 2 pylori pylori NN cord-011310-fm578rm5 222 3 resistance resistance NN cord-011310-fm578rm5 222 4 to to IN cord-011310-fm578rm5 222 5 antibiotics antibiotic NNS cord-011310-fm578rm5 222 6 in in IN cord-011310-fm578rm5 222 7 Europe Europe NNP cord-011310-fm578rm5 222 8 and and CC cord-011310-fm578rm5 222 9 its -PRON- PRP$ cord-011310-fm578rm5 222 10 relationship relationship NN cord-011310-fm578rm5 222 11 to to IN cord-011310-fm578rm5 222 12 antibiotic antibiotic JJ cord-011310-fm578rm5 222 13 consumption consumption NN cord-011310-fm578rm5 223 1 The the DT cord-011310-fm578rm5 223 2 threat threat NN cord-011310-fm578rm5 223 3 of of IN cord-011310-fm578rm5 223 4 antimicrobial antimicrobial JJ cord-011310-fm578rm5 223 5 resistance resistance NN cord-011310-fm578rm5 223 6 on on IN cord-011310-fm578rm5 223 7 the the DT cord-011310-fm578rm5 223 8 human human JJ cord-011310-fm578rm5 223 9 microbiome microbiome NN cord-011310-fm578rm5 224 1 Helicobacter Helicobacter NNP cord-011310-fm578rm5 224 2 pylori pylori NN cord-011310-fm578rm5 224 3 eradication eradication NN cord-011310-fm578rm5 224 4 causes cause VBZ cord-011310-fm578rm5 224 5 perturbation perturbation NN cord-011310-fm578rm5 224 6 of of IN cord-011310-fm578rm5 224 7 the the DT cord-011310-fm578rm5 224 8 human human JJ cord-011310-fm578rm5 224 9 gut gut NN cord-011310-fm578rm5 224 10 microbiome microbiome NN cord-011310-fm578rm5 224 11 in in IN cord-011310-fm578rm5 224 12 young young JJ cord-011310-fm578rm5 224 13 adults adult NNS cord-011310-fm578rm5 224 14 Effect Effect NNP cord-011310-fm578rm5 224 15 of of IN cord-011310-fm578rm5 224 16 azithromycin azithromycin NNP cord-011310-fm578rm5 224 17 and and CC cord-011310-fm578rm5 224 18 clarithromycin clarithromycin NNP cord-011310-fm578rm5 224 19 therapy therapy NN cord-011310-fm578rm5 224 20 on on IN cord-011310-fm578rm5 224 21 pharyngeal pharyngeal JJ cord-011310-fm578rm5 224 22 carriage carriage NN cord-011310-fm578rm5 224 23 of of IN cord-011310-fm578rm5 224 24 macrolide macrolide JJ cord-011310-fm578rm5 224 25 - - HYPH cord-011310-fm578rm5 224 26 resistant resistant JJ cord-011310-fm578rm5 224 27 streptococci streptococcus NNS cord-011310-fm578rm5 224 28 in in IN cord-011310-fm578rm5 224 29 healthy healthy JJ cord-011310-fm578rm5 224 30 volunteers volunteer NNS cord-011310-fm578rm5 224 31 : : : cord-011310-fm578rm5 225 1 a a DT cord-011310-fm578rm5 225 2 randomised randomised JJ cord-011310-fm578rm5 225 3 , , , cord-011310-fm578rm5 225 4 double double JJ cord-011310-fm578rm5 225 5 - - HYPH cord-011310-fm578rm5 225 6 blind blind JJ cord-011310-fm578rm5 225 7 , , , cord-011310-fm578rm5 225 8 placebo placebo NN cord-011310-fm578rm5 225 9 - - HYPH cord-011310-fm578rm5 225 10 controlled control VBN cord-011310-fm578rm5 225 11 study study NN cord-011310-fm578rm5 225 12 Kyoto Kyoto NNP cord-011310-fm578rm5 225 13 global global JJ cord-011310-fm578rm5 225 14 consensus consensus NN cord-011310-fm578rm5 225 15 report report NN cord-011310-fm578rm5 225 16 on on IN cord-011310-fm578rm5 225 17 Helicobacter Helicobacter NNP cord-011310-fm578rm5 225 18 pylori pylori NN cord-011310-fm578rm5 225 19 gastritis gastritis NN cord-011310-fm578rm5 225 20 IVth IVth NNP cord-011310-fm578rm5 225 21 Brazilian brazilian JJ cord-011310-fm578rm5 225 22 consensus consensus NN cord-011310-fm578rm5 225 23 conference conference NN cord-011310-fm578rm5 225 24 on on IN cord-011310-fm578rm5 225 25 Helicobacter Helicobacter NNP cord-011310-fm578rm5 225 26 pylori pylori NN cord-011310-fm578rm5 225 27 infection infection NN cord-011310-fm578rm5 226 1 Helicobacter Helicobacter NNP cord-011310-fm578rm5 226 2 pylori pylori NN cord-011310-fm578rm5 226 3 management management NN cord-011310-fm578rm5 226 4 in in IN cord-011310-fm578rm5 226 5 ASEAN ASEAN NNP cord-011310-fm578rm5 226 6 : : : cord-011310-fm578rm5 226 7 the the DT cord-011310-fm578rm5 226 8 Bangkok Bangkok NNP cord-011310-fm578rm5 226 9 consensus consensus NN cord-011310-fm578rm5 226 10 report report NN cord-011310-fm578rm5 226 11 Second Second NNP cord-011310-fm578rm5 226 12 Asia Asia NNP cord-011310-fm578rm5 226 13 - - HYPH cord-011310-fm578rm5 226 14 Pacific Pacific NNP cord-011310-fm578rm5 226 15 consensus consensus NN cord-011310-fm578rm5 226 16 guidelines guideline NNS cord-011310-fm578rm5 226 17 for for IN cord-011310-fm578rm5 226 18 Helicobacter Helicobacter NNP cord-011310-fm578rm5 226 19 pylori pylori NN cord-011310-fm578rm5 226 20 infection infection NN cord-011310-fm578rm5 227 1 ACG ACG NNP cord-011310-fm578rm5 227 2 clinical clinical JJ cord-011310-fm578rm5 227 3 guideline guideline NN cord-011310-fm578rm5 227 4 : : : cord-011310-fm578rm5 228 1 treatment treatment NN cord-011310-fm578rm5 228 2 of of IN cord-011310-fm578rm5 228 3 Helicobacter Helicobacter NNP cord-011310-fm578rm5 228 4 pylori pylori NN cord-011310-fm578rm5 228 5 infection infection NN cord-011310-fm578rm5 228 6 Prevention prevention NN cord-011310-fm578rm5 228 7 of of IN cord-011310-fm578rm5 228 8 gastric gastric JJ cord-011310-fm578rm5 228 9 cancer cancer NN cord-011310-fm578rm5 228 10 Impact impact NN cord-011310-fm578rm5 228 11 of of IN cord-011310-fm578rm5 228 12 health health NN cord-011310-fm578rm5 228 13 insurance insurance NN cord-011310-fm578rm5 228 14 coverage coverage NN cord-011310-fm578rm5 228 15 for for IN cord-011310-fm578rm5 228 16 Helicobacter helicobacter NN cord-011310-fm578rm5 228 17 pylori pylori NN cord-011310-fm578rm5 228 18 gastritis gastritis NN cord-011310-fm578rm5 228 19 on on IN cord-011310-fm578rm5 228 20 the the DT cord-011310-fm578rm5 228 21 trends trend NNS cord-011310-fm578rm5 228 22 in in IN cord-011310-fm578rm5 228 23 eradication eradication NN cord-011310-fm578rm5 228 24 therapy therapy NN cord-011310-fm578rm5 228 25 in in IN cord-011310-fm578rm5 228 26 Japan Japan NNP cord-011310-fm578rm5 228 27 : : : cord-011310-fm578rm5 228 28 retrospective retrospective JJ cord-011310-fm578rm5 228 29 observational observational JJ cord-011310-fm578rm5 228 30 study study NN cord-011310-fm578rm5 228 31 and and CC cord-011310-fm578rm5 228 32 simulation simulation NN cord-011310-fm578rm5 228 33 study study NN cord-011310-fm578rm5 228 34 based base VBN cord-011310-fm578rm5 228 35 on on IN cord-011310-fm578rm5 228 36 real real JJ cord-011310-fm578rm5 228 37 - - HYPH cord-011310-fm578rm5 228 38 world world NN cord-011310-fm578rm5 228 39 data datum NNS cord-011310-fm578rm5 228 40 Effect effect NN cord-011310-fm578rm5 228 41 of of IN cord-011310-fm578rm5 228 42 endoscopy endoscopy NN cord-011310-fm578rm5 228 43 screening screening NN cord-011310-fm578rm5 228 44 on on IN cord-011310-fm578rm5 228 45 stage stage NN cord-011310-fm578rm5 228 46 at at IN cord-011310-fm578rm5 228 47 gastric gastric JJ cord-011310-fm578rm5 228 48 cancer cancer NN cord-011310-fm578rm5 228 49 diagnosis diagnosis NN cord-011310-fm578rm5 228 50 : : : cord-011310-fm578rm5 228 51 results result NNS cord-011310-fm578rm5 228 52 of of IN cord-011310-fm578rm5 228 53 the the DT cord-011310-fm578rm5 228 54 national national JJ cord-011310-fm578rm5 228 55 cancer cancer NN cord-011310-fm578rm5 228 56 screening screening NN cord-011310-fm578rm5 228 57 programme programme NN cord-011310-fm578rm5 228 58 in in IN cord-011310-fm578rm5 228 59 Korea Korea NNP cord-011310-fm578rm5 228 60 Guidelines Guidelines NNPS cord-011310-fm578rm5 228 61 for for IN cord-011310-fm578rm5 228 62 the the DT cord-011310-fm578rm5 228 63 diagnosis diagnosis NN cord-011310-fm578rm5 228 64 and and CC cord-011310-fm578rm5 228 65 treatment treatment NN cord-011310-fm578rm5 228 66 of of IN cord-011310-fm578rm5 228 67 Helicobacter Helicobacter NNP cord-011310-fm578rm5 228 68 pylori pylori NN cord-011310-fm578rm5 228 69 infection infection NN cord-011310-fm578rm5 228 70 in in IN cord-011310-fm578rm5 228 71 Korea Korea NNP cord-011310-fm578rm5 228 72 Slovenian slovenian JJ cord-011310-fm578rm5 228 73 society society NN cord-011310-fm578rm5 228 74 for for IN cord-011310-fm578rm5 228 75 gastroenterology gastroenterology NN cord-011310-fm578rm5 228 76 and and CC cord-011310-fm578rm5 228 77 hepatology hepatology NN cord-011310-fm578rm5 228 78 guidelines guideline NNS cord-011310-fm578rm5 228 79 on on IN cord-011310-fm578rm5 228 80 the the DT cord-011310-fm578rm5 228 81 management management NN cord-011310-fm578rm5 228 82 of of IN cord-011310-fm578rm5 228 83 Helicobacter Helicobacter NNP cord-011310-fm578rm5 228 84 pylori pylori NN cord-011310-fm578rm5 228 85 infection infection NN cord-011310-fm578rm5 229 1 The the DT cord-011310-fm578rm5 229 2 Toronto Toronto NNP cord-011310-fm578rm5 229 3 consensus consensus NN cord-011310-fm578rm5 229 4 for for IN cord-011310-fm578rm5 229 5 the the DT cord-011310-fm578rm5 229 6 treatment treatment NN cord-011310-fm578rm5 229 7 of of IN cord-011310-fm578rm5 229 8 Helicobacter Helicobacter NNP cord-011310-fm578rm5 229 9 pylori pylori NN cord-011310-fm578rm5 229 10 infection infection NN cord-011310-fm578rm5 229 11 in in IN cord-011310-fm578rm5 229 12 adults adult NNS cord-011310-fm578rm5 229 13 Current current JJ cord-011310-fm578rm5 229 14 concepts concept NNS cord-011310-fm578rm5 229 15 in in IN cord-011310-fm578rm5 229 16 the the DT cord-011310-fm578rm5 229 17 management management NN cord-011310-fm578rm5 229 18 of of IN cord-011310-fm578rm5 229 19 Helicobacter Helicobacter NNP cord-011310-fm578rm5 229 20 pylori pylori NN cord-011310-fm578rm5 229 21 infection infection NN cord-011310-fm578rm5 229 22 : : : cord-011310-fm578rm5 229 23 the the DT cord-011310-fm578rm5 229 24 Maastricht Maastricht NNP cord-011310-fm578rm5 229 25 III III NNP cord-011310-fm578rm5 229 26 consensus consensus NN cord-011310-fm578rm5 229 27 report report NN cord-011310-fm578rm5 229 28 Management Management NNP cord-011310-fm578rm5 229 29 of of IN cord-011310-fm578rm5 229 30 Helicobacter Helicobacter NNP cord-011310-fm578rm5 229 31 pylori pylori NN cord-011310-fm578rm5 229 32 infection infection NN cord-011310-fm578rm5 229 33 - - : cord-011310-fm578rm5 229 34 the the DT cord-011310-fm578rm5 229 35 Maastricht Maastricht NNP cord-011310-fm578rm5 229 36 IV IV NNP cord-011310-fm578rm5 229 37 / / SYM cord-011310-fm578rm5 229 38 Florence Florence NNP cord-011310-fm578rm5 229 39 consensus consensus NN cord-011310-fm578rm5 229 40 report report NN cord-011310-fm578rm5 229 41 Principles principle NNS cord-011310-fm578rm5 229 42 and and CC cord-011310-fm578rm5 229 43 practice practice NN cord-011310-fm578rm5 229 44 of of IN cord-011310-fm578rm5 229 45 mass mass NN cord-011310-fm578rm5 229 46 screening screening NN cord-011310-fm578rm5 229 47 for for IN cord-011310-fm578rm5 229 48 disease disease NN cord-011310-fm578rm5 229 49 Revisiting revisit VBG cord-011310-fm578rm5 229 50 Wilson Wilson NNP cord-011310-fm578rm5 229 51 and and CC cord-011310-fm578rm5 229 52 Jungner Jungner NNP cord-011310-fm578rm5 229 53 in in IN cord-011310-fm578rm5 229 54 the the DT cord-011310-fm578rm5 229 55 genomic genomic JJ cord-011310-fm578rm5 229 56 age age NN cord-011310-fm578rm5 229 57 : : : cord-011310-fm578rm5 229 58 a a DT cord-011310-fm578rm5 229 59 review review NN cord-011310-fm578rm5 229 60 of of IN cord-011310-fm578rm5 229 61 screening screen VBG cord-011310-fm578rm5 229 62 criteria criterion NNS cord-011310-fm578rm5 229 63 over over IN cord-011310-fm578rm5 229 64 the the DT cord-011310-fm578rm5 229 65 past past JJ cord-011310-fm578rm5 229 66 40 40 CD cord-011310-fm578rm5 229 67 years year NNS cord-011310-fm578rm5 229 68 Systematic systematic JJ cord-011310-fm578rm5 229 69 review review NN cord-011310-fm578rm5 229 70 with with IN cord-011310-fm578rm5 229 71 meta meta NNP cord-011310-fm578rm5 229 72 - - HYPH cord-011310-fm578rm5 229 73 analysis analysis NN cord-011310-fm578rm5 229 74 : : : cord-011310-fm578rm5 230 1 the the DT cord-011310-fm578rm5 230 2 worldwide worldwide JJ cord-011310-fm578rm5 230 3 prevalence prevalence NN cord-011310-fm578rm5 230 4 of of IN cord-011310-fm578rm5 230 5 Helicobacter Helicobacter NNP cord-011310-fm578rm5 230 6 pylori pylori NN cord-011310-fm578rm5 230 7 infection infection NN cord-011310-fm578rm5 230 8 Prevalence prevalence NN cord-011310-fm578rm5 230 9 of of IN cord-011310-fm578rm5 230 10 chronic chronic JJ cord-011310-fm578rm5 230 11 atrophic atrophic JJ cord-011310-fm578rm5 230 12 gastritis gastritis NN cord-011310-fm578rm5 230 13 in in IN cord-011310-fm578rm5 230 14 different different JJ cord-011310-fm578rm5 230 15 parts part NNS cord-011310-fm578rm5 230 16 of of IN cord-011310-fm578rm5 230 17 the the DT cord-011310-fm578rm5 230 18 world world NN cord-011310-fm578rm5 230 19 Eradication Eradication NNP cord-011310-fm578rm5 230 20 therapy therapy NN cord-011310-fm578rm5 230 21 in in IN cord-011310-fm578rm5 230 22 Helicobacter Helicobacter NNP cord-011310-fm578rm5 230 23 pylori pylori VB cord-011310-fm578rm5 230 24 positive positive JJ cord-011310-fm578rm5 230 25 peptic peptic JJ cord-011310-fm578rm5 230 26 ulcer ulcer NN cord-011310-fm578rm5 230 27 disease disease NN cord-011310-fm578rm5 230 28 : : : cord-011310-fm578rm5 230 29 systematic systematic JJ cord-011310-fm578rm5 230 30 review review NN cord-011310-fm578rm5 230 31 and and CC cord-011310-fm578rm5 230 32 economic economic JJ cord-011310-fm578rm5 230 33 analysis analysis NN cord-011310-fm578rm5 230 34 National National NNP cord-011310-fm578rm5 230 35 Institute Institute NNP cord-011310-fm578rm5 230 36 for for IN cord-011310-fm578rm5 230 37 Health Health NNP cord-011310-fm578rm5 230 38 and and CC cord-011310-fm578rm5 230 39 Care Care NNP cord-011310-fm578rm5 230 40 Excellence Excellence NNP cord-011310-fm578rm5 230 41 N. n. NN cord-011310-fm578rm5 230 42 Clostridium clostridium NN cord-011310-fm578rm5 230 43 difficile difficile NN cord-011310-fm578rm5 230 44 infection infection NN cord-011310-fm578rm5 230 45 : : : cord-011310-fm578rm5 230 46 risk risk NN cord-011310-fm578rm5 230 47 with with IN cord-011310-fm578rm5 230 48 broad broad JJ cord-011310-fm578rm5 230 49 - - HYPH cord-011310-fm578rm5 230 50 spectrum spectrum NN cord-011310-fm578rm5 230 51 antibiotics antibiotic NNS cord-011310-fm578rm5 230 52 . . . cord-011310-fm578rm5 231 1 2015 2015 CD cord-011310-fm578rm5 231 2 ; ; : cord-011310-fm578rm5 231 3 nice.org.uk/guida nice.org.uk/guida NNP cord-011310-fm578rm5 231 4 nce nce NNP cord-011310-fm578rm5 231 5 / / SYM cord-011310-fm578rm5 231 6 esmpb esmpb NNP cord-011310-fm578rm5 231 7 1 1 CD cord-011310-fm578rm5 231 8 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 231 9 - - HYPH cord-011310-fm578rm5 231 10 associated associate VBN cord-011310-fm578rm5 231 11 risk risk NN cord-011310-fm578rm5 231 12 factors factor NNS cord-011310-fm578rm5 231 13 for for IN cord-011310-fm578rm5 231 14 Clostridium clostridium NN cord-011310-fm578rm5 231 15 difficile difficile NN cord-011310-fm578rm5 231 16 infection infection NN cord-011310-fm578rm5 232 1 Pseudomembranous pseudomembranous JJ cord-011310-fm578rm5 232 2 colitis colitis NN cord-011310-fm578rm5 232 3 associated associate VBN cord-011310-fm578rm5 232 4 with with IN cord-011310-fm578rm5 232 5 a a DT cord-011310-fm578rm5 232 6 triple triple JJ cord-011310-fm578rm5 232 7 therapy therapy NN cord-011310-fm578rm5 232 8 for for IN cord-011310-fm578rm5 232 9 Helicobacter Helicobacter NNP cord-011310-fm578rm5 232 10 pylori pylori NN cord-011310-fm578rm5 232 11 eradication eradication NN cord-011310-fm578rm5 232 12 Recovery recovery NN cord-011310-fm578rm5 232 13 of of IN cord-011310-fm578rm5 232 14 gut gut NN cord-011310-fm578rm5 232 15 microbiota microbiota NN cord-011310-fm578rm5 232 16 of of IN cord-011310-fm578rm5 232 17 healthy healthy JJ cord-011310-fm578rm5 232 18 adults adult NNS cord-011310-fm578rm5 232 19 following follow VBG cord-011310-fm578rm5 232 20 antibiotic antibiotic JJ cord-011310-fm578rm5 232 21 exposure exposure NN cord-011310-fm578rm5 233 1 Gut gut JJ cord-011310-fm578rm5 233 2 bacterial bacterial JJ cord-011310-fm578rm5 233 3 microbiota microbiota NN cord-011310-fm578rm5 233 4 and and CC cord-011310-fm578rm5 233 5 its -PRON- PRP$ cord-011310-fm578rm5 233 6 resistome resistome NN cord-011310-fm578rm5 233 7 rapidly rapidly RB cord-011310-fm578rm5 233 8 recover recover VBP cord-011310-fm578rm5 233 9 to to IN cord-011310-fm578rm5 233 10 basal basal NN cord-011310-fm578rm5 233 11 state state NN cord-011310-fm578rm5 233 12 levels level NNS cord-011310-fm578rm5 233 13 after after IN cord-011310-fm578rm5 233 14 short short JJ cord-011310-fm578rm5 233 15 - - HYPH cord-011310-fm578rm5 233 16 term term NN cord-011310-fm578rm5 233 17 amoxicillin amoxicillin NNP cord-011310-fm578rm5 233 18 - - HYPH cord-011310-fm578rm5 233 19 clavulanic clavulanic NNP cord-011310-fm578rm5 233 20 acid acid NN cord-011310-fm578rm5 233 21 treatment treatment NN cord-011310-fm578rm5 233 22 in in IN cord-011310-fm578rm5 233 23 healthy healthy JJ cord-011310-fm578rm5 233 24 adults adult NNS cord-011310-fm578rm5 234 1 The the DT cord-011310-fm578rm5 234 2 antibiotic antibiotic JJ cord-011310-fm578rm5 234 3 resistome resistome NNP cord-011310-fm578rm5 234 4 : : : cord-011310-fm578rm5 234 5 the the DT cord-011310-fm578rm5 234 6 nexus nexus NN cord-011310-fm578rm5 234 7 of of IN cord-011310-fm578rm5 234 8 chemical chemical JJ cord-011310-fm578rm5 234 9 and and CC cord-011310-fm578rm5 234 10 genetic genetic JJ cord-011310-fm578rm5 234 11 diversity diversity NN cord-011310-fm578rm5 234 12 nature nature NN cord-011310-fm578rm5 234 13 reviews review NNS cord-011310-fm578rm5 235 1 The the DT cord-011310-fm578rm5 235 2 human human JJ cord-011310-fm578rm5 235 3 gut gut NN cord-011310-fm578rm5 235 4 resistome resistome NNP cord-011310-fm578rm5 235 5 Country country NN cord-011310-fm578rm5 235 6 - - HYPH cord-011310-fm578rm5 235 7 specific specific JJ cord-011310-fm578rm5 235 8 antibiotic antibiotic JJ cord-011310-fm578rm5 235 9 use use NN cord-011310-fm578rm5 235 10 practices practice NNS cord-011310-fm578rm5 235 11 impact impact VBP cord-011310-fm578rm5 235 12 the the DT cord-011310-fm578rm5 235 13 human human JJ cord-011310-fm578rm5 235 14 gut gut NN cord-011310-fm578rm5 235 15 resistome resistome VBN cord-011310-fm578rm5 235 16 Clarithromycin Clarithromycin NNP cord-011310-fm578rm5 235 17 treatment treatment NN cord-011310-fm578rm5 235 18 selects select VBZ cord-011310-fm578rm5 235 19 for for IN cord-011310-fm578rm5 235 20 persistent persistent JJ cord-011310-fm578rm5 235 21 macrolide macrolide JJ cord-011310-fm578rm5 235 22 - - HYPH cord-011310-fm578rm5 235 23 resistant resistant JJ cord-011310-fm578rm5 235 24 bacteria bacteria NNS cord-011310-fm578rm5 235 25 in in IN cord-011310-fm578rm5 235 26 throat throat NN cord-011310-fm578rm5 236 1 commensal commensal JJ cord-011310-fm578rm5 236 2 flora flora NNS cord-011310-fm578rm5 236 3 Macrolide Macrolide NNP cord-011310-fm578rm5 236 4 resistance resistance NN cord-011310-fm578rm5 236 5 in in IN cord-011310-fm578rm5 236 6 the the DT cord-011310-fm578rm5 236 7 normal normal JJ cord-011310-fm578rm5 236 8 microbiota microbiota NN cord-011310-fm578rm5 236 9 after after IN cord-011310-fm578rm5 236 10 Helicobacter Helicobacter NNP cord-011310-fm578rm5 236 11 pylori pylori NN cord-011310-fm578rm5 236 12 treatment treatment NN cord-011310-fm578rm5 236 13 Long long JJ cord-011310-fm578rm5 236 14 - - HYPH cord-011310-fm578rm5 236 15 term term NN cord-011310-fm578rm5 236 16 persistence persistence NN cord-011310-fm578rm5 236 17 of of IN cord-011310-fm578rm5 236 18 resistant resistant JJ cord-011310-fm578rm5 236 19 Enterococcus enterococcus NN cord-011310-fm578rm5 236 20 species specie NNS cord-011310-fm578rm5 236 21 after after IN cord-011310-fm578rm5 236 22 antibiotics antibiotic NNS cord-011310-fm578rm5 236 23 to to TO cord-011310-fm578rm5 236 24 eradicate eradicate VB cord-011310-fm578rm5 236 25 Helicobacter Helicobacter NNP cord-011310-fm578rm5 236 26 pylori pylori VB cord-011310-fm578rm5 237 1 Short short JJ cord-011310-fm578rm5 237 2 - - HYPH cord-011310-fm578rm5 237 3 term term NN cord-011310-fm578rm5 237 4 antibiotic antibiotic JJ cord-011310-fm578rm5 237 5 treatment treatment NN cord-011310-fm578rm5 237 6 has have VBZ cord-011310-fm578rm5 237 7 differing differ VBG cord-011310-fm578rm5 237 8 long long JJ cord-011310-fm578rm5 237 9 - - HYPH cord-011310-fm578rm5 237 10 term term NN cord-011310-fm578rm5 237 11 impacts impact NNS cord-011310-fm578rm5 237 12 on on IN cord-011310-fm578rm5 237 13 the the DT cord-011310-fm578rm5 237 14 human human JJ cord-011310-fm578rm5 237 15 throat throat NN cord-011310-fm578rm5 237 16 and and CC cord-011310-fm578rm5 237 17 gut gut NN cord-011310-fm578rm5 237 18 microbiome microbiome NN cord-011310-fm578rm5 238 1 Long long JJ cord-011310-fm578rm5 238 2 term term NN cord-011310-fm578rm5 238 3 changes change NNS cord-011310-fm578rm5 238 4 of of IN cord-011310-fm578rm5 238 5 gut gut NN cord-011310-fm578rm5 238 6 microbiota microbiota NN cord-011310-fm578rm5 238 7 , , , cord-011310-fm578rm5 238 8 antibiotic antibiotic JJ cord-011310-fm578rm5 238 9 resistance resistance NN cord-011310-fm578rm5 238 10 , , , cord-011310-fm578rm5 238 11 and and CC cord-011310-fm578rm5 238 12 metabolic metabolic JJ cord-011310-fm578rm5 238 13 parameters parameter NNS cord-011310-fm578rm5 238 14 after after IN cord-011310-fm578rm5 238 15 Helicobacter Helicobacter NNP cord-011310-fm578rm5 238 16 pylori pylori NN cord-011310-fm578rm5 238 17 eradication eradication NN cord-011310-fm578rm5 238 18 a a DT cord-011310-fm578rm5 238 19 multicentre multicentre NNP cord-011310-fm578rm5 238 20 randomised randomised JJ cord-011310-fm578rm5 238 21 trial trial NN cord-011310-fm578rm5 238 22 Finnish Finnish NNP cord-011310-fm578rm5 238 23 Study Study NNP cord-011310-fm578rm5 238 24 Group Group NNP cord-011310-fm578rm5 238 25 for for IN cord-011310-fm578rm5 238 26 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 238 27 R. R. NNP cord-011310-fm578rm5 238 28 Macrolide Macrolide NNP cord-011310-fm578rm5 238 29 and and CC cord-011310-fm578rm5 238 30 azithromycin azithromycin NNP cord-011310-fm578rm5 238 31 use use NN cord-011310-fm578rm5 238 32 are be VBP cord-011310-fm578rm5 238 33 linked link VBN cord-011310-fm578rm5 238 34 to to IN cord-011310-fm578rm5 238 35 increased increase VBN cord-011310-fm578rm5 238 36 macrolide macrolide JJ cord-011310-fm578rm5 238 37 resistance resistance NN cord-011310-fm578rm5 238 38 in in IN cord-011310-fm578rm5 238 39 Streptococcus Streptococcus NNP cord-011310-fm578rm5 238 40 pneumoniae pneumoniae NN cord-011310-fm578rm5 238 41 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 238 42 drug drug NN cord-011310-fm578rm5 238 43 use use NN cord-011310-fm578rm5 238 44 and and CC cord-011310-fm578rm5 238 45 methicillin methicillin NN cord-011310-fm578rm5 238 46 - - HYPH cord-011310-fm578rm5 238 47 resistant resistant JJ cord-011310-fm578rm5 238 48 Staphylococcus Staphylococcus NNP cord-011310-fm578rm5 238 49 aureus aureus NN cord-011310-fm578rm5 238 50 Editorial Editorial NNP cord-011310-fm578rm5 238 51 commentary commentary NN cord-011310-fm578rm5 238 52 : : : cord-011310-fm578rm5 238 53 antibiotics antibiotic NNS cord-011310-fm578rm5 238 54 for for IN cord-011310-fm578rm5 238 55 treatment treatment NN cord-011310-fm578rm5 238 56 of of IN cord-011310-fm578rm5 238 57 acute acute JJ cord-011310-fm578rm5 238 58 respiratory respiratory JJ cord-011310-fm578rm5 238 59 tract tract NN cord-011310-fm578rm5 238 60 infections infection NNS cord-011310-fm578rm5 238 61 : : : cord-011310-fm578rm5 238 62 decreasing decrease VBG cord-011310-fm578rm5 238 63 benefit benefit NN cord-011310-fm578rm5 238 64 , , , cord-011310-fm578rm5 238 65 increasing increase VBG cord-011310-fm578rm5 238 66 risk risk NN cord-011310-fm578rm5 238 67 , , , cord-011310-fm578rm5 238 68 and and CC cord-011310-fm578rm5 238 69 the the DT cord-011310-fm578rm5 238 70 irrelevance irrelevance NN cord-011310-fm578rm5 238 71 of of IN cord-011310-fm578rm5 238 72 antimicrobial antimicrobial JJ cord-011310-fm578rm5 238 73 resistance resistance NN cord-011310-fm578rm5 238 74 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 238 75 stewardship stewardship NN cord-011310-fm578rm5 238 76 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 238 77 stewardship stewardship NN cord-011310-fm578rm5 238 78 in in IN cord-011310-fm578rm5 238 79 small small JJ cord-011310-fm578rm5 238 80 animal animal NN cord-011310-fm578rm5 238 81 veterinary veterinary JJ cord-011310-fm578rm5 238 82 practice practice NN cord-011310-fm578rm5 238 83 : : : cord-011310-fm578rm5 238 84 from from IN cord-011310-fm578rm5 238 85 theory theory NN cord-011310-fm578rm5 238 86 to to TO cord-011310-fm578rm5 238 87 practice practice VB cord-011310-fm578rm5 238 88 Minnesota Minnesota NNP cord-011310-fm578rm5 238 89 Department Department NNP cord-011310-fm578rm5 238 90 of of IN cord-011310-fm578rm5 238 91 Health Health NNP cord-011310-fm578rm5 238 92 . . . cord-011310-fm578rm5 239 1 One one CD cord-011310-fm578rm5 239 2 Health Health NNP cord-011310-fm578rm5 239 3 Antibiotic Antibiotic NNP cord-011310-fm578rm5 239 4 Stewardship Stewardship NNP cord-011310-fm578rm5 239 5 Collaborative Collaborative NNP cord-011310-fm578rm5 239 6 World World NNP cord-011310-fm578rm5 239 7 Health Health NNP cord-011310-fm578rm5 239 8 Organization Organization NNP cord-011310-fm578rm5 239 9 . . . cord-011310-fm578rm5 240 1 2nd 2nd NNP cord-011310-fm578rm5 240 2 Consultation Consultation NNP cord-011310-fm578rm5 240 3 of of IN cord-011310-fm578rm5 240 4 Member Member NNP cord-011310-fm578rm5 240 5 States States NNP cord-011310-fm578rm5 240 6 and and CC cord-011310-fm578rm5 240 7 Partners Partners NNPS cord-011310-fm578rm5 240 8 on on IN cord-011310-fm578rm5 240 9 the the DT cord-011310-fm578rm5 240 10 Global Global NNP cord-011310-fm578rm5 240 11 Development Development NNP cord-011310-fm578rm5 240 12 and and CC cord-011310-fm578rm5 240 13 Stewardship Stewardship NNP cord-011310-fm578rm5 240 14 Framework Framework NNP cord-011310-fm578rm5 240 15 to to IN cord-011310-fm578rm5 240 16 What what WP cord-011310-fm578rm5 240 17 is be VBZ cord-011310-fm578rm5 240 18 antimicrobial antimicrobial JJ cord-011310-fm578rm5 240 19 stewardship stewardship NN cord-011310-fm578rm5 240 20 ? ? . cord-011310-fm578rm5 241 1 Lessons lesson NNS cord-011310-fm578rm5 241 2 learnt learn VBD cord-011310-fm578rm5 241 3 during during IN cord-011310-fm578rm5 241 4 20 20 CD cord-011310-fm578rm5 241 5 years year NNS cord-011310-fm578rm5 241 6 of of IN cord-011310-fm578rm5 241 7 the the DT cord-011310-fm578rm5 241 8 Swedish swedish JJ cord-011310-fm578rm5 241 9 strategic strategic JJ cord-011310-fm578rm5 241 10 programme programme NN cord-011310-fm578rm5 241 11 against against IN cord-011310-fm578rm5 241 12 antibiotic antibiotic JJ cord-011310-fm578rm5 241 13 resistance resistance NN cord-011310-fm578rm5 241 14 European European NNP cord-011310-fm578rm5 241 15 Centre Centre NNP cord-011310-fm578rm5 241 16 for for IN cord-011310-fm578rm5 241 17 Disease Disease NNP cord-011310-fm578rm5 241 18 Prevention Prevention NNP cord-011310-fm578rm5 241 19 and and CC cord-011310-fm578rm5 241 20 Control Control NNP cord-011310-fm578rm5 241 21 . . . cord-011310-fm578rm5 242 1 Antimicrobial antimicrobial JJ cord-011310-fm578rm5 242 2 consumption consumption NN cord-011310-fm578rm5 242 3 National national JJ cord-011310-fm578rm5 242 4 action action NN cord-011310-fm578rm5 242 5 plan plan NN cord-011310-fm578rm5 242 6 for for IN cord-011310-fm578rm5 242 7 combating combat VBG cord-011310-fm578rm5 242 8 antibiotic antibiotic JJ cord-011310-fm578rm5 242 9 - - HYPH cord-011310-fm578rm5 242 10 resistant resistant JJ cord-011310-fm578rm5 242 11 bacteria bacteria NNS cord-011310-fm578rm5 242 12 Guideline Guideline NNP cord-011310-fm578rm5 242 13 Development Development NNP cord-011310-fm578rm5 242 14 G. G. NNP cord-011310-fm578rm5 242 15 Diagnosis Diagnosis NNP cord-011310-fm578rm5 242 16 and and CC cord-011310-fm578rm5 242 17 management management NN cord-011310-fm578rm5 242 18 of of IN cord-011310-fm578rm5 242 19 community community NN cord-011310-fm578rm5 242 20 and and CC cord-011310-fm578rm5 242 21 hospital hospital NN cord-011310-fm578rm5 242 22 acquired acquire VBD cord-011310-fm578rm5 242 23 pneumonia pneumonia NN cord-011310-fm578rm5 242 24 in in IN cord-011310-fm578rm5 242 25 adults adult NNS cord-011310-fm578rm5 242 26 : : : cord-011310-fm578rm5 242 27 summary summary NN cord-011310-fm578rm5 242 28 of of IN cord-011310-fm578rm5 242 29 NICE nice JJ cord-011310-fm578rm5 242 30 guidance guidance NN cord-011310-fm578rm5 242 31 Management Management NNP cord-011310-fm578rm5 242 32 of of IN cord-011310-fm578rm5 242 33 community community NN cord-011310-fm578rm5 242 34 - - HYPH cord-011310-fm578rm5 242 35 acquired acquire VBN cord-011310-fm578rm5 242 36 pneumonia pneumonia NN cord-011310-fm578rm5 242 37 in in IN cord-011310-fm578rm5 242 38 adults adult NNS cord-011310-fm578rm5 242 39 : : : cord-011310-fm578rm5 243 1 2016 2016 CD cord-011310-fm578rm5 243 2 guideline guideline NN cord-011310-fm578rm5 243 3 update update NN cord-011310-fm578rm5 243 4 from from IN cord-011310-fm578rm5 243 5 the the DT cord-011310-fm578rm5 243 6 Dutch Dutch NNP cord-011310-fm578rm5 243 7 Working Working NNP cord-011310-fm578rm5 243 8 Party Party NNP cord-011310-fm578rm5 243 9 on on IN cord-011310-fm578rm5 243 10 Antibiotic Antibiotic NNP cord-011310-fm578rm5 243 11 Policy Policy NNP cord-011310-fm578rm5 243 12 ( ( -LRB- cord-011310-fm578rm5 243 13 SWAB swab NN cord-011310-fm578rm5 243 14 ) ) -RRB- cord-011310-fm578rm5 243 15 and and CC cord-011310-fm578rm5 243 16 Dutch Dutch NNP cord-011310-fm578rm5 243 17 Association Association NNP cord-011310-fm578rm5 243 18 of of IN cord-011310-fm578rm5 243 19 Chest Chest NNP cord-011310-fm578rm5 243 20 Physicians Physicians NNPS cord-011310-fm578rm5 243 21 Swedish swedish JJ cord-011310-fm578rm5 243 22 guidelines guideline NNS cord-011310-fm578rm5 243 23 on on IN cord-011310-fm578rm5 243 24 the the DT cord-011310-fm578rm5 243 25 management management NN cord-011310-fm578rm5 243 26 of of IN cord-011310-fm578rm5 243 27 community community NN cord-011310-fm578rm5 243 28 - - HYPH cord-011310-fm578rm5 243 29 acquired acquire VBN cord-011310-fm578rm5 243 30 pneumonia pneumonia NN cord-011310-fm578rm5 243 31 in in IN cord-011310-fm578rm5 243 32 immunocompetent immunocompetent JJ cord-011310-fm578rm5 243 33 adults adult NNS cord-011310-fm578rm5 243 34 - - : cord-011310-fm578rm5 243 35 Swedish swedish JJ cord-011310-fm578rm5 243 36 society society NN cord-011310-fm578rm5 243 37 of of IN cord-011310-fm578rm5 243 38 infectious infectious JJ cord-011310-fm578rm5 243 39 diseases disease NNS cord-011310-fm578rm5 243 40 2012 2012 CD cord-011310-fm578rm5 243 41 Infectious infectious JJ cord-011310-fm578rm5 243 42 diseases disease NNS cord-011310-fm578rm5 243 43 society society NN cord-011310-fm578rm5 243 44 of of IN cord-011310-fm578rm5 243 45 America America NNP cord-011310-fm578rm5 243 46 / / SYM cord-011310-fm578rm5 243 47 American american JJ cord-011310-fm578rm5 243 48 thoracic thoracic JJ cord-011310-fm578rm5 243 49 society society NN cord-011310-fm578rm5 243 50 consensus consensus NN cord-011310-fm578rm5 243 51 guidelines guideline NNS cord-011310-fm578rm5 243 52 on on IN cord-011310-fm578rm5 243 53 the the DT cord-011310-fm578rm5 243 54 management management NN cord-011310-fm578rm5 243 55 of of IN cord-011310-fm578rm5 243 56 community community NN cord-011310-fm578rm5 243 57 - - HYPH cord-011310-fm578rm5 243 58 acquired acquire VBN cord-011310-fm578rm5 243 59 pneumonia pneumonia NN cord-011310-fm578rm5 243 60 in in IN cord-011310-fm578rm5 243 61 adults adult NNS cord-011310-fm578rm5 244 1 Antimicrobial antimicrobial JJ cord-011310-fm578rm5 244 2 resistance resistance NN cord-011310-fm578rm5 244 3 following follow VBG cord-011310-fm578rm5 244 4 mass mass NN cord-011310-fm578rm5 244 5 azithromycin azithromycin NN cord-011310-fm578rm5 244 6 distribution distribution NN cord-011310-fm578rm5 244 7 for for IN cord-011310-fm578rm5 244 8 trachoma trachoma NN cord-011310-fm578rm5 244 9 : : : cord-011310-fm578rm5 244 10 a a DT cord-011310-fm578rm5 244 11 systematic systematic JJ cord-011310-fm578rm5 244 12 review review NN cord-011310-fm578rm5 244 13 Global Global NNP cord-011310-fm578rm5 244 14 Cancer Cancer NNP cord-011310-fm578rm5 244 15 Observatory Observatory NNP cord-011310-fm578rm5 244 16 : : : cord-011310-fm578rm5 245 1 Cancer Cancer NNP cord-011310-fm578rm5 245 2 Today today NN cord-011310-fm578rm5 245 3 . . . cord-011310-fm578rm5 246 1 Lyon Lyon NNP cord-011310-fm578rm5 246 2 : : : cord-011310-fm578rm5 247 1 International International NNP cord-011310-fm578rm5 247 2 Agency Agency NNP cord-011310-fm578rm5 247 3 for for IN cord-011310-fm578rm5 247 4 Research Research NNP cord-011310-fm578rm5 247 5 on on IN cord-011310-fm578rm5 247 6 Cancer Cancer NNP cord-011310-fm578rm5 247 7 Prevalence prevalence NN cord-011310-fm578rm5 247 8 of of IN cord-011310-fm578rm5 247 9 Helicobacter Helicobacter NNP cord-011310-fm578rm5 247 10 pylori pylori NN cord-011310-fm578rm5 247 11 infection infection NN cord-011310-fm578rm5 247 12 and and CC cord-011310-fm578rm5 247 13 atrophic atrophic JJ cord-011310-fm578rm5 247 14 gastritis gastritis NN cord-011310-fm578rm5 247 15 in in IN cord-011310-fm578rm5 247 16 Latvia Latvia NNP cord-011310-fm578rm5 248 1 A a DT cord-011310-fm578rm5 248 2 systematic systematic JJ cord-011310-fm578rm5 248 3 review review NN cord-011310-fm578rm5 248 4 of of IN cord-011310-fm578rm5 248 5 treating treat VBG cord-011310-fm578rm5 248 6 Helicobacter Helicobacter NNP cord-011310-fm578rm5 248 7 pylori pylori NN cord-011310-fm578rm5 248 8 infection infection NN cord-011310-fm578rm5 248 9 with with IN cord-011310-fm578rm5 248 10 traditional traditional JJ cord-011310-fm578rm5 248 11 Chinese chinese JJ cord-011310-fm578rm5 248 12 medicine medicine NN cord-011310-fm578rm5 248 13 Antimicrobial Antimicrobial NNP cord-011310-fm578rm5 248 14 activity activity NN cord-011310-fm578rm5 248 15 of of IN cord-011310-fm578rm5 248 16 natural natural JJ cord-011310-fm578rm5 248 17 products product NNS cord-011310-fm578rm5 248 18 against against IN cord-011310-fm578rm5 248 19 Helicobacter Helicobacter NNP cord-011310-fm578rm5 248 20 pylori pylori NN cord-011310-fm578rm5 248 21 : : : cord-011310-fm578rm5 248 22 a a DT cord-011310-fm578rm5 248 23 review review NN cord-011310-fm578rm5 248 24 Review review NN cord-011310-fm578rm5 248 25 : : : cord-011310-fm578rm5 248 26 pharmacological pharmacological JJ cord-011310-fm578rm5 248 27 ins in NNS cord-011310-fm578rm5 248 28 and and CC cord-011310-fm578rm5 248 29 outs out NNS cord-011310-fm578rm5 248 30 of of IN cord-011310-fm578rm5 248 31 medicinal medicinal JJ cord-011310-fm578rm5 248 32 plants plant NNS cord-011310-fm578rm5 248 33 against against IN cord-011310-fm578rm5 248 34 Helicobacter Helicobacter NNP cord-011310-fm578rm5 248 35 pylori pylori NN cord-011310-fm578rm5 248 36 : : : cord-011310-fm578rm5 248 37 a a DT cord-011310-fm578rm5 248 38 review review NN cord-011310-fm578rm5 248 39 Non non JJ cord-011310-fm578rm5 248 40 - - JJ cord-011310-fm578rm5 248 41 pharmacological pharmacological JJ cord-011310-fm578rm5 248 42 treatment treatment NN cord-011310-fm578rm5 248 43 of of IN cord-011310-fm578rm5 248 44 Helicobacter Helicobacter NNP cord-011310-fm578rm5 248 45 pylori pylori NN cord-011310-fm578rm5 249 1 Probiotic probiotic JJ cord-011310-fm578rm5 249 2 monotherapy monotherapy NN cord-011310-fm578rm5 249 3 and and CC cord-011310-fm578rm5 249 4 Helicobacter Helicobacter NNP cord-011310-fm578rm5 249 5 pylori pylori NN cord-011310-fm578rm5 249 6 eradication eradication NN cord-011310-fm578rm5 249 7 : : : cord-011310-fm578rm5 249 8 a a DT cord-011310-fm578rm5 249 9 systematic systematic JJ cord-011310-fm578rm5 249 10 review review NN cord-011310-fm578rm5 249 11 with with IN cord-011310-fm578rm5 249 12 pooled pool VBN cord-011310-fm578rm5 249 13 - - HYPH cord-011310-fm578rm5 249 14 data data NN cord-011310-fm578rm5 249 15 analysis analysis NN cord-011310-fm578rm5 250 1 Selective selective JJ cord-011310-fm578rm5 250 2 killing killing NN cord-011310-fm578rm5 250 3 of of IN cord-011310-fm578rm5 250 4 Helicobacter Helicobacter NNP cord-011310-fm578rm5 250 5 pylori pylori NN cord-011310-fm578rm5 250 6 with with IN cord-011310-fm578rm5 250 7 pH ph NN cord-011310-fm578rm5 250 8 - - HYPH cord-011310-fm578rm5 250 9 responsive responsive JJ cord-011310-fm578rm5 250 10 helix helix NN cord-011310-fm578rm5 250 11 - - HYPH cord-011310-fm578rm5 250 12 coil coil NN cord-011310-fm578rm5 250 13 conformation conformation NN cord-011310-fm578rm5 250 14 transitionable transitionable NN cord-011310-fm578rm5 250 15 antimicrobial antimicrobial JJ cord-011310-fm578rm5 250 16 polypeptides polypeptide NNS cord-011310-fm578rm5 250 17 Docosahexaenoic Docosahexaenoic NNP cord-011310-fm578rm5 250 18 acid acid NN cord-011310-fm578rm5 250 19 loaded loaded JJ cord-011310-fm578rm5 250 20 lipid lipid NN cord-011310-fm578rm5 250 21 nanoparticles nanoparticle NNS cord-011310-fm578rm5 250 22 with with IN cord-011310-fm578rm5 250 23 bactericidal bactericidal JJ cord-011310-fm578rm5 250 24 activity activity NN cord-011310-fm578rm5 250 25 against against IN cord-011310-fm578rm5 250 26 Helicobacter Helicobacter NNP cord-011310-fm578rm5 250 27 pylori pylori NN cord-011310-fm578rm5 250 28 Lipid lipid NN cord-011310-fm578rm5 250 29 nanoparticles nanoparticle NNS cord-011310-fm578rm5 250 30 to to TO cord-011310-fm578rm5 250 31 counteract counteract VB cord-011310-fm578rm5 250 32 gastric gastric JJ cord-011310-fm578rm5 250 33 infection infection NN cord-011310-fm578rm5 250 34 without without IN cord-011310-fm578rm5 250 35 affecting affect VBG cord-011310-fm578rm5 250 36 gut gut NN cord-011310-fm578rm5 250 37 microbiota microbiota NN cord-011310-fm578rm5 250 38 High High NNP cord-011310-fm578rm5 250 39 dose dose NN cord-011310-fm578rm5 250 40 ilaprazole/ ilaprazole/ CD cord-011310-fm578rm5 250 41 amoxicillin amoxicillin NNP cord-011310-fm578rm5 250 42 as as IN cord-011310-fm578rm5 250 43 first first JJ cord-011310-fm578rm5 250 44 - - HYPH cord-011310-fm578rm5 250 45 line line NN cord-011310-fm578rm5 250 46 regimen regimen NN cord-011310-fm578rm5 250 47 for for IN cord-011310-fm578rm5 250 48 Helicobacter Helicobacter NNP cord-011310-fm578rm5 250 49 pylori pylori NN cord-011310-fm578rm5 250 50 infection infection NN cord-011310-fm578rm5 250 51 in in IN cord-011310-fm578rm5 250 52 Korea Korea NNP cord-011310-fm578rm5 250 53 High High NNP cord-011310-fm578rm5 250 54 and and CC cord-011310-fm578rm5 250 55 frequent frequent JJ cord-011310-fm578rm5 250 56 dose dose NN cord-011310-fm578rm5 250 57 of of IN cord-011310-fm578rm5 250 58 dexlansoprazole dexlansoprazole NNP cord-011310-fm578rm5 250 59 and and CC cord-011310-fm578rm5 250 60 amoxicillin amoxicillin NNP cord-011310-fm578rm5 250 61 dual dual JJ cord-011310-fm578rm5 250 62 therapy therapy NN cord-011310-fm578rm5 250 63 for for IN cord-011310-fm578rm5 250 64 Helicobacter Helicobacter NNP cord-011310-fm578rm5 250 65 pylori pylori NN cord-011310-fm578rm5 250 66 infections infection NNS cord-011310-fm578rm5 250 67 : : : cord-011310-fm578rm5 251 1 a a DT cord-011310-fm578rm5 251 2 single single JJ cord-011310-fm578rm5 251 3 arm arm NN cord-011310-fm578rm5 251 4 prospective prospective JJ cord-011310-fm578rm5 251 5 study study NN cord-011310-fm578rm5 251 6 High High NNP cord-011310-fm578rm5 251 7 - - HYPH cord-011310-fm578rm5 251 8 dose dose NN cord-011310-fm578rm5 251 9 esomeprazole esomeprazole NNP cord-011310-fm578rm5 251 10 and and CC cord-011310-fm578rm5 251 11 amoxicillin amoxicillin NNP cord-011310-fm578rm5 251 12 dual dual JJ cord-011310-fm578rm5 251 13 therapy therapy NN cord-011310-fm578rm5 251 14 for for IN cord-011310-fm578rm5 251 15 first first JJ cord-011310-fm578rm5 251 16 - - HYPH cord-011310-fm578rm5 251 17 line line NN cord-011310-fm578rm5 251 18 Helicobacter Helicobacter NNP cord-011310-fm578rm5 251 19 pylori pylori NN cord-011310-fm578rm5 251 20 eradication eradication NN cord-011310-fm578rm5 251 21 : : : cord-011310-fm578rm5 251 22 a a DT cord-011310-fm578rm5 251 23 proof proof NN cord-011310-fm578rm5 251 24 of of IN cord-011310-fm578rm5 251 25 concept concept NN cord-011310-fm578rm5 251 26 study study NN cord-011310-fm578rm5 251 27 Role role NN cord-011310-fm578rm5 251 28 of of IN cord-011310-fm578rm5 251 29 bismuth bismuth NN cord-011310-fm578rm5 251 30 in in IN cord-011310-fm578rm5 251 31 improving improve VBG cord-011310-fm578rm5 251 32 Helicobacter Helicobacter NNP cord-011310-fm578rm5 251 33 pylori pylori NN cord-011310-fm578rm5 251 34 eradication eradication NN cord-011310-fm578rm5 251 35 with with IN cord-011310-fm578rm5 251 36 triple triple JJ cord-011310-fm578rm5 251 37 therapy therapy NN cord-011310-fm578rm5 252 1 Understanding understand VBG cord-011310-fm578rm5 252 2 treatment treatment NN cord-011310-fm578rm5 252 3 guidelines guideline NNS cord-011310-fm578rm5 252 4 with with IN cord-011310-fm578rm5 252 5 bismuth bismuth NN cord-011310-fm578rm5 252 6 and and CC cord-011310-fm578rm5 252 7 non non JJ cord-011310-fm578rm5 252 8 - - JJ cord-011310-fm578rm5 252 9 bismuth bismuth JJ cord-011310-fm578rm5 252 10 quadruple quadruple JJ cord-011310-fm578rm5 252 11 Helicobacter helicobacter NN cord-011310-fm578rm5 253 1 pylori pylori NN cord-011310-fm578rm5 253 2 eradication eradication NN cord-011310-fm578rm5 253 3 therapies therapy NNS cord-011310-fm578rm5 254 1 Adverse adverse JJ cord-011310-fm578rm5 254 2 events event NNS cord-011310-fm578rm5 254 3 with with IN cord-011310-fm578rm5 254 4 bismuth bismuth NN cord-011310-fm578rm5 254 5 salts salt NNS cord-011310-fm578rm5 254 6 for for IN cord-011310-fm578rm5 254 7 Helicobacter Helicobacter NNP cord-011310-fm578rm5 254 8 pylori pylori NN cord-011310-fm578rm5 254 9 eradication eradication NN cord-011310-fm578rm5 254 10 : : : cord-011310-fm578rm5 254 11 systematic systematic JJ cord-011310-fm578rm5 254 12 review review NN cord-011310-fm578rm5 254 13 and and CC cord-011310-fm578rm5 254 14 meta meta NNP cord-011310-fm578rm5 254 15 - - HYPH cord-011310-fm578rm5 254 16 analysis analysis NN cord-011310-fm578rm5 254 17 Bismuth Bismuth NNP cord-011310-fm578rm5 254 18 supplements supplement NNS cord-011310-fm578rm5 254 19 as as IN cord-011310-fm578rm5 254 20 the the DT cord-011310-fm578rm5 254 21 first first JJ cord-011310-fm578rm5 254 22 - - HYPH cord-011310-fm578rm5 254 23 line line NN cord-011310-fm578rm5 254 24 regimen regimen NN cord-011310-fm578rm5 254 25 for for IN cord-011310-fm578rm5 254 26 Helicobacter Helicobacter NNP cord-011310-fm578rm5 255 1 pylori pylori NNP cord-011310-fm578rm5 255 2 eradication eradication NN cord-011310-fm578rm5 255 3 therapy therapy NN cord-011310-fm578rm5 255 4 : : : cord-011310-fm578rm5 255 5 systemic systemic JJ cord-011310-fm578rm5 255 6 review review NN cord-011310-fm578rm5 255 7 and and CC cord-011310-fm578rm5 255 8 meta meta NNP cord-011310-fm578rm5 255 9 - - HYPH cord-011310-fm578rm5 255 10 analysis analysis NN cord-011310-fm578rm5 255 11 Meta Meta NNP cord-011310-fm578rm5 255 12 - - HYPH cord-011310-fm578rm5 255 13 analysis analysis NN cord-011310-fm578rm5 255 14 of of IN cord-011310-fm578rm5 255 15 threein threein NNP cord-011310-fm578rm5 255 16 - - HYPH cord-011310-fm578rm5 255 17 one one CD cord-011310-fm578rm5 255 18 single single JJ cord-011310-fm578rm5 255 19 capsule capsule NN cord-011310-fm578rm5 255 20 bismuth bismuth NN cord-011310-fm578rm5 255 21 - - HYPH cord-011310-fm578rm5 255 22 containing contain VBG cord-011310-fm578rm5 255 23 quadruple quadruple JJ cord-011310-fm578rm5 255 24 therapy therapy NN cord-011310-fm578rm5 255 25 for for IN cord-011310-fm578rm5 255 26 the the DT cord-011310-fm578rm5 255 27 eradication eradication NN cord-011310-fm578rm5 255 28 of of IN cord-011310-fm578rm5 255 29 Helicobacter Helicobacter NNP cord-011310-fm578rm5 255 30 pylori pylori NN cord-011310-fm578rm5 255 31 Helicobacter helicobacter NN cord-011310-fm578rm5 255 32 pylori pylori NN cord-011310-fm578rm5 256 1 eradication eradication NN cord-011310-fm578rm5 256 2 with with IN cord-011310-fm578rm5 256 3 bismuth bismuth NN cord-011310-fm578rm5 256 4 quadruple quadruple NN cord-011310-fm578rm5 256 5 therapy therapy NN cord-011310-fm578rm5 256 6 leads lead VBZ cord-011310-fm578rm5 256 7 to to IN cord-011310-fm578rm5 256 8 dysbiosis dysbiosis NN cord-011310-fm578rm5 256 9 of of IN cord-011310-fm578rm5 256 10 gut gut NN cord-011310-fm578rm5 256 11 microbiota microbiota NN cord-011310-fm578rm5 256 12 with with IN cord-011310-fm578rm5 256 13 an an DT cord-011310-fm578rm5 256 14 increased increase VBN cord-011310-fm578rm5 256 15 relative relative JJ cord-011310-fm578rm5 256 16 abundance abundance NN cord-011310-fm578rm5 256 17 of of IN cord-011310-fm578rm5 256 18 Proteobacteria Proteobacteria NNP cord-011310-fm578rm5 256 19 and and CC cord-011310-fm578rm5 256 20 decreased decrease VBD cord-011310-fm578rm5 256 21 relative relative JJ cord-011310-fm578rm5 256 22 abundances abundance NNS cord-011310-fm578rm5 256 23 of of IN cord-011310-fm578rm5 256 24 Bacteroidetes Bacteroidetes NNPS cord-011310-fm578rm5 256 25 and and CC cord-011310-fm578rm5 256 26 Actinobacteria Actinobacteria NNP cord-011310-fm578rm5 256 27 Treating treat VBG cord-011310-fm578rm5 256 28 Helicobacter Helicobacter NNP cord-011310-fm578rm5 256 29 pylori pylori NN cord-011310-fm578rm5 256 30 effectively effectively RB cord-011310-fm578rm5 256 31 while while IN cord-011310-fm578rm5 256 32 minimizing minimize VBG cord-011310-fm578rm5 256 33 misuse misuse NN cord-011310-fm578rm5 256 34 of of IN cord-011310-fm578rm5 256 35 antibiotics antibiotic NNS cord-011310-fm578rm5 256 36 Screening screen VBG cord-011310-fm578rm5 256 37 for for IN cord-011310-fm578rm5 256 38 gastric gastric JJ cord-011310-fm578rm5 256 39 cancer cancer NN cord-011310-fm578rm5 256 40 and and CC cord-011310-fm578rm5 256 41 surveillance surveillance NN cord-011310-fm578rm5 256 42 of of IN cord-011310-fm578rm5 256 43 premalignant premalignant JJ cord-011310-fm578rm5 256 44 lesions lesion NNS cord-011310-fm578rm5 256 45 : : : cord-011310-fm578rm5 256 46 a a DT cord-011310-fm578rm5 256 47 systematic systematic JJ cord-011310-fm578rm5 256 48 review review NN cord-011310-fm578rm5 256 49 of of IN cord-011310-fm578rm5 256 50 cost cost NN cord-011310-fm578rm5 256 51 - - HYPH cord-011310-fm578rm5 256 52 effectiveness effectiveness NN cord-011310-fm578rm5 256 53 studies study NNS cord-011310-fm578rm5 256 54 Cost cost NN cord-011310-fm578rm5 256 55 - - HYPH cord-011310-fm578rm5 256 56 effectiveness effectiveness NN cord-011310-fm578rm5 256 57 of of IN cord-011310-fm578rm5 256 58 screening screening NN cord-011310-fm578rm5 256 59 and and CC cord-011310-fm578rm5 256 60 treating treat VBG cord-011310-fm578rm5 256 61 Helicobacter helicobacter NN cord-011310-fm578rm5 256 62 pylori pylori NN cord-011310-fm578rm5 256 63 for for IN cord-011310-fm578rm5 256 64 gastric gastric JJ cord-011310-fm578rm5 256 65 cancer cancer NN cord-011310-fm578rm5 256 66 prevention prevention NN cord-011310-fm578rm5 257 1 Helicobacter Helicobacter NNP cord-011310-fm578rm5 257 2 pylori pylori NN cord-011310-fm578rm5 257 3 eradication eradication NN cord-011310-fm578rm5 257 4 therapy therapy NN cord-011310-fm578rm5 257 5 to to TO cord-011310-fm578rm5 257 6 prevent prevent VB cord-011310-fm578rm5 257 7 gastric gastric JJ cord-011310-fm578rm5 257 8 cancer cancer NN cord-011310-fm578rm5 257 9 in in IN cord-011310-fm578rm5 257 10 healthy healthy JJ cord-011310-fm578rm5 257 11 asymptomatic asymptomatic JJ cord-011310-fm578rm5 257 12 infected infected JJ cord-011310-fm578rm5 257 13 individuals individual NNS cord-011310-fm578rm5 257 14 : : : cord-011310-fm578rm5 257 15 systematic systematic JJ cord-011310-fm578rm5 257 16 review review NN cord-011310-fm578rm5 257 17 and and CC cord-011310-fm578rm5 257 18 metaanalysis metaanalysis NN cord-011310-fm578rm5 257 19 of of IN cord-011310-fm578rm5 257 20 randomised randomised JJ cord-011310-fm578rm5 257 21 controlled control VBN cord-011310-fm578rm5 257 22 trials trial NNS cord-011310-fm578rm5 258 1 The the DT cord-011310-fm578rm5 258 2 cost cost NN cord-011310-fm578rm5 258 3 effectiveness effectiveness NN cord-011310-fm578rm5 258 4 of of IN cord-011310-fm578rm5 258 5 Helicobacter Helicobacter NNP cord-011310-fm578rm5 258 6 pylori pylori NN cord-011310-fm578rm5 258 7 population population NN cord-011310-fm578rm5 258 8 screening screening NN cord-011310-fm578rm5 258 9 - - HYPH cord-011310-fm578rm5 258 10 economic economic JJ cord-011310-fm578rm5 258 11 evaluation evaluation NN cord-011310-fm578rm5 258 12 alongside alongside IN cord-011310-fm578rm5 258 13 a a DT cord-011310-fm578rm5 258 14 randomised randomised JJ cord-011310-fm578rm5 258 15 controlled control VBN cord-011310-fm578rm5 258 16 trial trial NN cord-011310-fm578rm5 258 17 with with IN cord-011310-fm578rm5 258 18 13-year 13-year JJ cord-011310-fm578rm5 258 19 follow follow NN cord-011310-fm578rm5 258 20 - - HYPH cord-011310-fm578rm5 258 21 up up NN cord-011310-fm578rm5 258 22 Cost cost NN cord-011310-fm578rm5 258 23 - - HYPH cord-011310-fm578rm5 258 24 effectiveness effectiveness NN cord-011310-fm578rm5 258 25 analysis analysis NN cord-011310-fm578rm5 258 26 of of IN cord-011310-fm578rm5 258 27 screen screen NN cord-011310-fm578rm5 258 28 - - HYPH cord-011310-fm578rm5 258 29 and and CC cord-011310-fm578rm5 258 30 - - HYPH cord-011310-fm578rm5 258 31 treat treat VB cord-011310-fm578rm5 258 32 strategy strategy NN cord-011310-fm578rm5 258 33 in in IN cord-011310-fm578rm5 258 34 asymptomatic asymptomatic JJ cord-011310-fm578rm5 258 35 Chinese Chinese NNP cord-011310-fm578rm5 258 36 for for IN cord-011310-fm578rm5 258 37 preventing prevent VBG cord-011310-fm578rm5 258 38 Helicobacter Helicobacter NNP cord-011310-fm578rm5 258 39 pylori pylori NN cord-011310-fm578rm5 258 40 - - HYPH cord-011310-fm578rm5 258 41 associated associate VBN cord-011310-fm578rm5 258 42 diseases disease NNS cord-011310-fm578rm5 258 43 Cost cost NN cord-011310-fm578rm5 258 44 - - HYPH cord-011310-fm578rm5 258 45 effectiveness effectiveness NN cord-011310-fm578rm5 258 46 of of IN cord-011310-fm578rm5 258 47 Helicobacter Helicobacter NNP cord-011310-fm578rm5 258 48 pylori pylori NN cord-011310-fm578rm5 258 49 screening screening NN cord-011310-fm578rm5 258 50 followed follow VBN cord-011310-fm578rm5 258 51 by by IN cord-011310-fm578rm5 258 52 eradication eradication NN cord-011310-fm578rm5 258 53 treatment treatment NN cord-011310-fm578rm5 258 54 for for IN cord-011310-fm578rm5 258 55 employees employee NNS cord-011310-fm578rm5 258 56 in in IN cord-011310-fm578rm5 258 57 Japan Japan NNP cord-011310-fm578rm5 259 1 The the DT cord-011310-fm578rm5 259 2 true true JJ cord-011310-fm578rm5 259 3 cost cost NN cord-011310-fm578rm5 259 4 of of IN cord-011310-fm578rm5 259 5 antimicrobial antimicrobial JJ cord-011310-fm578rm5 259 6 resistance resistance NN cord-011310-fm578rm5 260 1 The the DT cord-011310-fm578rm5 260 2 hidden hidden JJ cord-011310-fm578rm5 260 3 societal societal JJ cord-011310-fm578rm5 260 4 cost cost NN cord-011310-fm578rm5 260 5 of of IN cord-011310-fm578rm5 260 6 antibiotic antibiotic JJ cord-011310-fm578rm5 260 7 resistance resistance NN cord-011310-fm578rm5 260 8 per per IN cord-011310-fm578rm5 260 9 antibiotic antibiotic JJ cord-011310-fm578rm5 260 10 prescribed prescribe VBN cord-011310-fm578rm5 260 11 in in IN cord-011310-fm578rm5 260 12 the the DT cord-011310-fm578rm5 260 13 United United NNP cord-011310-fm578rm5 260 14 States States NNP cord-011310-fm578rm5 260 15 : : : cord-011310-fm578rm5 260 16 an an DT cord-011310-fm578rm5 260 17 exploratory exploratory JJ cord-011310-fm578rm5 260 18 analysis analysis NN cord-011310-fm578rm5 260 19 Mass Mass NNP cord-011310-fm578rm5 260 20 eradication eradication NN cord-011310-fm578rm5 260 21 of of IN cord-011310-fm578rm5 260 22 Helicobacter Helicobacter NNP cord-011310-fm578rm5 260 23 pylori pylori NN cord-011310-fm578rm5 260 24 to to TO cord-011310-fm578rm5 260 25 prevent prevent VB cord-011310-fm578rm5 260 26 gastric gastric JJ cord-011310-fm578rm5 260 27 cancer cancer NN cord-011310-fm578rm5 260 28 : : : cord-011310-fm578rm5 260 29 theoretical theoretical JJ cord-011310-fm578rm5 260 30 and and CC cord-011310-fm578rm5 260 31 practical practical JJ cord-011310-fm578rm5 260 32 considerations consideration NNS cord-011310-fm578rm5 260 33 Effects effect NNS cord-011310-fm578rm5 260 34 of of IN cord-011310-fm578rm5 260 35 community community NN cord-011310-fm578rm5 260 36 screening screening NN cord-011310-fm578rm5 260 37 for for IN cord-011310-fm578rm5 260 38 Helicobacter Helicobacter NNP cord-011310-fm578rm5 260 39 pylori pylori NN cord-011310-fm578rm5 260 40 : : : cord-011310-fm578rm5 261 1 13-year 13-year JJ cord-011310-fm578rm5 261 2 follow follow NN cord-011310-fm578rm5 261 3 - - HYPH cord-011310-fm578rm5 261 4 up up NN cord-011310-fm578rm5 261 5 evaluation evaluation NN cord-011310-fm578rm5 261 6 of of IN cord-011310-fm578rm5 261 7 a a DT cord-011310-fm578rm5 261 8 randomized randomized JJ cord-011310-fm578rm5 261 9 controlled control VBN cord-011310-fm578rm5 261 10 trial trial NN cord-011310-fm578rm5 261 11 Multicentric Multicentric NNP cord-011310-fm578rm5 261 12 randomised randomised JJ cord-011310-fm578rm5 261 13 study study NN cord-011310-fm578rm5 261 14 of of IN cord-011310-fm578rm5 261 15 Helicobacter Helicobacter NNP cord-011310-fm578rm5 261 16 pylori pylori NN cord-011310-fm578rm5 261 17 eradication eradication NN cord-011310-fm578rm5 261 18 and and CC cord-011310-fm578rm5 261 19 pepsinogen pepsinogen NN cord-011310-fm578rm5 261 20 testing testing NN cord-011310-fm578rm5 261 21 for for IN cord-011310-fm578rm5 261 22 prevention prevention NN cord-011310-fm578rm5 261 23 of of IN cord-011310-fm578rm5 261 24 gastric gastric JJ cord-011310-fm578rm5 261 25 cancer cancer NN cord-011310-fm578rm5 261 26 mortality mortality NN cord-011310-fm578rm5 261 27 : : : cord-011310-fm578rm5 262 1 the the DT cord-011310-fm578rm5 262 2 GISTAR GISTAR NNP cord-011310-fm578rm5 262 3 study study NN cord-011310-fm578rm5 262 4 Acknowledgments acknowledgment NNS cord-011310-fm578rm5 263 1 The the DT cord-011310-fm578rm5 263 2 work work NN cord-011310-fm578rm5 263 3 was be VBD cord-011310-fm578rm5 263 4 supported support VBN cord-011310-fm578rm5 263 5 by by IN cord-011310-fm578rm5 263 6 ERDF ERDF NNP cord-011310-fm578rm5 263 7 ( ( -LRB- cord-011310-fm578rm5 263 8 European European NNP cord-011310-fm578rm5 263 9 Regional Regional NNP cord-011310-fm578rm5 263 10 Development Development NNP cord-011310-fm578rm5 263 11 Fund Fund NNP cord-011310-fm578rm5 263 12 ) ) -RRB- cord-011310-fm578rm5 263 13 in in IN cord-011310-fm578rm5 263 14 Latvia Latvia NNP cord-011310-fm578rm5 263 15 , , , cord-011310-fm578rm5 263 16 Project Project NNP cord-011310-fm578rm5 263 17 i -PRON- PRP cord-011310-fm578rm5 263 18 d d NN cord-011310-fm578rm5 263 19 . . . cord-011310-fm578rm5 263 20 nr nr NNP cord-011310-fm578rm5 263 21 . . . cord-011310-fm578rm5 264 1 1.1.1.1/18/A/184 1.1.1.1/18/a/184 CD cord-011310-fm578rm5 264 2 ' ' POS cord-011310-fm578rm5 264 3 Optimisation Optimisation NNP cord-011310-fm578rm5 264 4 of of IN cord-011310-fm578rm5 264 5 H. H. NNP cord-011310-fm578rm5 264 6 pylori pylori NN cord-011310-fm578rm5 264 7 eradication eradication NN cord-011310-fm578rm5 264 8 therapy therapy NN cord-011310-fm578rm5 264 9 for for IN cord-011310-fm578rm5 264 10 population population NN cord-011310-fm578rm5 264 11 - - HYPH cord-011310-fm578rm5 264 12 based base VBN cord-011310-fm578rm5 264 13 gastric gastric JJ cord-011310-fm578rm5 264 14 cancer cancer NN cord-011310-fm578rm5 264 15 prevention prevention NN cord-011310-fm578rm5 264 16 ' ' '' cord-011310-fm578rm5 264 17 . . . cord-011310-fm578rm5 265 1 Conflict conflict NN cord-011310-fm578rm5 265 2 of of IN cord-011310-fm578rm5 265 3 interest interest NN cord-011310-fm578rm5 266 1 The the DT cord-011310-fm578rm5 266 2 authors author NNS cord-011310-fm578rm5 266 3 declare declare VBP cord-011310-fm578rm5 266 4 that that IN cord-011310-fm578rm5 266 5 they -PRON- PRP cord-011310-fm578rm5 266 6 have have VBP cord-011310-fm578rm5 266 7 no no DT cord-011310-fm578rm5 266 8 conflict conflict NN cord-011310-fm578rm5 266 9 of of IN cord-011310-fm578rm5 266 10 interest interest NN cord-011310-fm578rm5 266 11 . . .